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Monkey: Management of ONtology and KEY-identity of cells
Monkey, Management of ONtology and KEY-identity of cells, is designed for single-cell management by introducing the concept of the United Kingdom of Single Cells (UKSC), where each cell is treated as a unique entity with an individual identifier (e.g., UKSC000818226). To facilitate comprehensive cell characterization, a passport is generated for each cell, encompassing four key components: Fingerprint (gene expression matrix visualized as a heatmap), GeneSetScore (pathway-specific gene set scoring for over 100 pathways), GeneSetRank (ranking of genes within each pathway), and Background (meta-information for the cell). This framework provides a structured and in-depth view of single-cell transcriptomics, enabling systematic cell identity management and functional annotatio
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  • Stem
  • Aging
  • Death
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  • Imprinting
  • Metabolism
  • Virus
  • Devo
  • DrugTargets
  • TFsig
  • Longevity
  • Pain
  • HypoxiaGenes
  • HumanSpecificGenes
  • CircadianGene
  • PrimateSpecific
  • NeuralGenes
  • InnateImmunity
  • Obesity
  • Cyto
  • UltraConserved
  • Organelle
  • SleepDisorders
  • StressResponse
  • GlycoGene
  • Immune
  • FishGenes
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • Hs_ESC_Wong
  • Hs_ESC_Wong
  • 335
  • ABCB7;ACAD8;ADH5;ADSL;AK3L1;ALDH7A1;ALDOC;AMOTL2;ANP32E;APEX1;ATP5J;ATP5O;AURKA;...
  • Hs_MSC_Huang
  • Hs_MSC_Huang
  • 59
  • ADAM12;ADAMTS1;ADAMTS5;ALDH1A3;CDH11;CEMIP;COL12A1;COL1A1;COL1A2;COL3A1;COL6A1;C...
  • Hs_MaSC_Pece
  • Hs_MaSC_Pece
  • 305
  • ABHD6;ACER3;ACTG1;AK1;AK2;AKR1C1;AKR1C2;ANKH;ANKRD10;ANP32E;APOE;APP;ARHGEF2;ARM...
  • Hs_iPSC_Shats
  • Hs_iPSC_Shats
  • 80
  • AASS;ACAA2;ALDH3B1;AMT;AP1M2;ARFGEF1;ASML3B;ATP6V0E;ATP6V1D;BMPR1A;CCNB1IP1;CDO1...
  • Hs_ESC_OCT4_targets_Boyer
  • Hs_ESC_OCT4_targets_Boyer
  • 289
  • AASDH;ABTB2;ACD;ADD3;ALKBH1;AMIGO2;ANKHD1;ANKRD1;ANKRD15;ARID1B;ARMCX5;ARPC5;ATA...
  • Hs_ESC_SOX2_targets_Boyer
  • Hs_ESC_SOX2_targets_Boyer
  • 730
  • AASDH;ABCB7;ABCF2;ABHD11;ABLIM1;ABTB2;ACIN1;ACO2;ACOT8;ACOX1;ACTR1A;ADAR;ADD3;AD...
  • Hs_ESC_Chia
  • Hs_ESC_Chia
  • 507
  • AADACL2;ABCG8;ABP1;ABTB1;ACADS;ACBD3;ACPL2;ACSS1;ACTA1;ACTL6B;ACTR1B;ACTR6;ADA;A...
  • KEGG
  • KEGG
  • 136
  • ACVR1;ACVR1B;ACVR1C;ACVR2A;ACVR2B;AKT1;AKT2;AKT3;APC;AXIN1;AXIN2;BMI1;BMP2;BMP4;...
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  • Remark
  • GeneNum
  • GeneList
  • AgingAtlasSig
  • AgingAtlasAgingSig
  • 503
  • IL2RB;PSAT1;A2M;AARS1;ABL1;ADCY1;ADCY2;ADCY3;ADCY4;ADCY5;ADCY6;ADCY7;ADCY8;ADCY9...
  • AgingSig
  • AgingSig
  • 37
  • AXL;BCL2;CCL2;CCL3;CCL4;CCL5;CDKN1A;CDKN2A;CDKN2B;CDKN2D;CSF1;CSF2RA;CXCL1;CXCL8...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • Apoptosis
  • Apoptosis (from Ancient Greek: ?¦Ð?¦Ð¦Ó¦Ø¦Ò¦É?, romanized: ap¨®pt¨­sis, lit.?'falling off') is a form of programmed cell death that occurs in multicellular organisms and in some eukaryotic, single-celled microorganisms such as yeast.[1] Biochemical events lead to characteristic cell changes (morphology) and death.[2] These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses 50 to 70 billion cells each day due to apoptosis.[a] For the average human child between 8 and 14 years old, each day the approximate loss is 20 to 30 billion cells.[4]
  • 580
  • ADAMTSL4-AS1;AKT1;APAF1;BAD;BAK1;BAX;BBC3;BCL2;BCL2L1;BCL2L11;BCL2L2;BID;BIRC2;B...
  • Ferroptosis
  • Oxytosis/ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis.[1][2] Oxytosis/ferroptosis is initiated by the failure of the glutathione-dependent antioxidant defenses, resulting in unchecked lipid peroxidation and eventual cell death.[3] Lipophilic antioxidants[4] and iron chelators[5] can prevent ferroptotic cell death. Although the connection between iron and lipid peroxidation has been appreciated for years,[6] it was not until 2012 that Brent Stockwell and Scott J. Dixon coined the term ferroptosis and described several of its key features.[5] Pamela Maher and David Schubert discovered the process in 2001 and called it oxytosis. While they did not describe the involvement of iron at the time, oxytosis and ferroptosis are today thought to be the same cell death mechanism.
  • 88
  • ACSL1;ACSL3;ACSL4;ACSL5;ACSL6;AIFM2;AKR1C1;AKR1C2;AKR1C3;ALOX15;ATG5;ATG7;BACH1;...
  • Necroptosis
  • Necroptosis is a programmed form of necrosis, or inflammatory cell death.[1] Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always the preferred form of cell death. Furthermore, the immunogenic nature of necroptosis favors its participation in certain circumstances, such as aiding in defence against pathogens by the immune system. Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication.[2] In addition to being a response to disease, necroptosis has also been characterized as a component of inflammatory diseases such as Crohn's disease, pancreatitis, and myocardial infarction.[3][4]
  • 101
  • GLUD1;ALOX15;FTH1;PYG;CAPN1;FADD;TNF;TNFRSF1A;TRADD;TRAF2;PPIA;CAPN2;HSP90A;IL1A...
  • Parthanatos
  • Parthanatos (derived from the Greek ¦¨?¦Í¦Á¦Ó¦Ï?, "Death") is a form of programmed cell death that is distinct from other cell death processes such as necrosis and apoptosis. While necrosis is caused by acute cell injury resulting in traumatic cell death and apoptosis is a highly controlled process signalled by apoptotic intracellular signals, parthanatos is caused by the accumulation of Poly(ADP ribose) (PAR) and the nuclear translocation of apoptosis-inducing factor (AIF) from mitochondria.[1] Parthanatos is also known as PARP-1 dependent cell death. PARP-1 mediates parthanatos when it is over-activated in response to extreme genomic stress and synthesizes PAR which causes nuclear translocation of AIF.[2] Parthanatos is involved in diseases that afflict hundreds of millions of people worldwide. Well known diseases involving parthanatos include Parkinson's disease, stroke, heart attack, and diabetes.[citation needed] It also has potential use as a treatment for ameliorating disease and various medical conditions such as diabetes and obesity.[citation needed]
  • 9
  • PARP;MIF;AIFM1;HSP70;PAAN;ARH3;RNF146;ADPRHL2;OGG1
  • EntoticCellDeath
  • Entotic cell death
  • 15
  • AMPK;ATG5;ATG7;BECN1;CDC42;CDH1;CTNNA1;CYBB;MYH14;PI3KC3;RHOA;RNF146;ROCK;RUBCN;...
  • Netotic cell death
  • Netotic cell death
  • 7
  • PAD4;ELANE;MPO;CAMP;EIPA;NCX1;MIA
  • Lysosome-dependent cell death
  • Lysosome-dependent cell death
  • 75
  • LIPA;PPT;NAGPA;GALNS;ARSA;ARSB;IDS;GNS;DNASE2;NEU1;GLA;E3;uidA;hya;GBA;GALC;NAGA...
  • Oxeiptosis
  • Oxeiptosis
  • 5
  • PGAM5;KEAP1;AIFM1;NRF2;AIRE
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  • NFkapaB signaling pathway
  • Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.
  • 41
  • IL1A;TNF;IL1R1;TNFRSF1A;TNFRSF1B;IKBKG;IKBKG;RELA;IKBKG;NFKB1;MYD88;MYD88;MYD88;...
  • MAPK signaling pathway
  • The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
  • 267
  • AKT3;PLA2G4B;RASGRP1;RASGRP2;CACNG3;CACNG2;TAB1;MAP3K2;GADD45G;DUSP14;MAP4K1;DUS...
  • JAK/STAT signaling pathway
  • The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
  • 155
  • AKT3;SPRY3;SPRY1;SPRY2;STAM2;IRF9;PIAS3;IL24;CISH;IL22RA2;SOCS4;CNTF;CNTFR;CREBB...
  • Notch signaling pathway
  • The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.
  • 47
  • DLL3;RBPJL;DTX2;CREBBP;CTBP1;CTBP2;DTX3L;PTCRA;JAG1;DTX1;DVL1;DVL2;DVL3;DTX3;EP3...
  • Hippo signaling pathway
  • Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor Salvador and LATS1 and LATS2. In response to high cell densities, activated LATS1/2 phosphorylates the transcriptional coactivators YAP and TAZ, promoting its cytoplasmic localization, leading to cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated at low cell density, YAP/TAZ translocates into the nucleus to bind to the transcription enhancer factor (TEAD/TEF) family of transcriptional factors to promote cell growth and proliferation. YAP/TAZ also interacts with other transcriptional factors or signaling molecules, by which Hippo pathway-mediated processes are interconnected with those of other key signaling cascades, such as those mediated by TGF-beta and Wnt growth factors.
  • 22
  • DVL2;WWTR1;STK4;TJP1;STK3;YWHAE;WWC1;AMOTL2;MOB1A;TJP2;AMOT;LATS1;NPHP4;YAP1;LAT...
  • ISHIKAWA_STING_SIGNALING
  • The cellular innate immune system is essential for recognizing pathogen infection and for establishing effective host defence. But critical molecular determinants responsible for facilitating an appropriate immune response-following infection with DNA and RNA viruses, for example-remain to be identified. Here we report the identification, following expression cloning, of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes. It comprises five putative transmembrane regions, predominantly resides in the endoplasmic reticulum and is able to activate both NF-kappaB and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta ) and exert a potent anti-viral state following expression. In contrast, loss of STING rendered murine embryonic fibroblasts extremely susceptible to negative-stranded virus infection, including vesicular stomatitis virus. Further, STING ablation abrogated the ability of intracellular B-form DNA, as well as members of the herpesvirus family, to induce IFN-beta, but did not significantly affect the Toll-like receptor (TLR) pathway. Yeast two-hybrid and co-immunoprecipitation studies indicated that STING interacts with RIG-I and with SSR2 (also known as TRAPbeta), which is a member of the translocon-associated protein (TRAP) complex required for protein translocation across the endoplasmic reticulum membrane following translation. Ablation by RNA interference of both TRAPbeta and translocon adaptor SEC61beta was subsequently found to inhibit STING's ability to stimulate expression of IFN-beta. Thus, as well as identifying a regulator of innate immune signalling, our results imply a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
  • 10
  • ADAR;IFNA1;IFNA4;IFNB1;IRF1;IRF2;IRF6;IRF7;IRF9;CCL5
  • ERK(Erk1/Erk2 Mapk) Signaling
  • The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network.
  • 63
  • SOS1;GNAS;IGF1R;KLK2;RPS6KA1;MAPK3;GNAS;GNAS;GNAS;MAPK3;ELK1;SHC1;SHC1;HRAS;MKNK...
  • BMP
  • Bone morphogenetic proteins (BMPs) have many biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. They are members of the Transforming growth factor-Beta (TGFB) family. They bind to type II and type I serine-threonine kinase receptors, which transduce signals through SMAD and non-SMAD signalling pathways. BMP signalling is linked to a wide variety of clinical disorders, including vascular diseases, skeletal diseases and cancer. BMPs typically activate BMP type I receptors and signal via SMAD1, 5 and 8. They can be classified into several subgroups, including the BMP2/4 group, the BMP5-8 osteogenic protein-1 (OP1) group, the growth and differentiation factor (GDF) 5-7 group and the BMP9/10 group.
  • 31
  • ZFYVE16;TGFBR3;UBE2D1;SMAD7;CHRDL1;AMH;BMPR1A;SMURF2;UBE2D3;SMAD5;ACVR2B;SMAD9;A...
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  • Remark
  • GeneNum
  • GeneList
  • BRIDEAU IMPRINTED GENES
  • List of genomically imprinted genes.
  • 65
  • AIRN;APOC2;ART5;ASB4;ATP10A;CALCR;CD81;CDKN1C;CMAHP;CNTN3;COMMD1;COPG2;DCN;DDC;D...
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  • Type
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  • GeneList
  • Pentose phosphate pathway
  • Pentose phosphate pathway
  • 30
  • GPI;G6PD;PGLS;H6PD;PGD;RPE;RPEL1;TKT;TKTL2;TKTL1;TALDO1;RPIA;DERA;RBKS;PGM1;PGM2...
  • Synthesis and degradation of ketone bodies
  • Synthesis and degradation of ketone bodies
  • 10
  • HMGCS1;HMGCS2;HMGCL;HMGCLL1;OXCT1;OXCT2;ACAT2;ACAT1;BDH1;BDH2
  • Sphingolipid metabolism
  • Sphingolipid metabolism
  • 47
  • SPTLC1;SPTLC2;SPTLC3;KDSR;CERS2;CERS3;CERS6;CERS1;CERS4;CERS5;ASAH1;ASAH2;ACER2;...
  • Linoleic acid metabolism
  • Linoleic acid metabolism
  • 29
  • PLA2G10;PLA2G2D;PLA2G2E;PLA2G3;PLA2G2F;PLA2G12A;PLA2G12B;PLA2G1B;PLA2G5;PLA2G2A;...
  • Pyrimidine metabolism
  • Pyrimidine metabolism
  • 101
  • CAD;DHODH;UMPS;CMPK1;CMPK2;NME6;NME7;NME2;NME4;NME1;NME3;NME1-NME2;AK9;PNPT1;ENT...
  • Glycosphingolipid biosynthesis - globo and isoglobo series
  • Glycosphingolipid biosynthesis - globo and isoglobo series
  • 15
  • A3GALT2;B3GALNT1;GBGT1;A4GALT;GLA;B3GALT5;HEXA;HEXB;NAGA;FUT1;FUT2;ST3GAL1;ST3GA...
  • Thiamine metabolism
  • Thiamine metabolism
  • 16
  • NFS1;NTPCR;ALPL;ALPI;ALPP;ALPG;ACP1;TPK1;AK7;AK4;AK5;AK2;AK1;adenylatekinaseisoe...
  • Drug metabolism - other enzymes
  • Drug metabolism - other enzymes
  • 80
  • HPRT1;IMPDH1;IMPDH2;GMPS;TPMT;XDH;ITPA;CES1;CES2;UGT2A1;UGT2A3;UGT2B17;UGT2B11;U...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • Coxsackievirus B5
  • Coxsackievirus B5
  • 2
  • CD55;CXADR
  • Ebola virus
  • Ebola virus
  • 8
  • NPC1;AXL;TYRO3;MERTK;CLEC4G;HAVCR1;CLEC4M;CD209
  • Hepacivirus C
  • Hepacivirus C
  • 10
  • CLDN1;EGFR;LDLR;TFRC;EPHA2;CD81;OCLN;SCARB1;CLEC4M;CD209
  • Human alphaherpesvirus 1
  • Human alphaherpesvirus 1
  • 7
  • ITGAV;ITGB6;ITGB8;NECTIN1;NECTIN2;TNFRSF14;CD209
  • Human gammaherpesvirus 4
  • Human gammaherpesvirus 4
  • 5
  • EFNA2;HLA-DRB1;ITGB1;CR1;CR2
  • Human gammaherpesvirus 8
  • Human gammaherpesvirus 8
  • 3
  • ITGB3;ITGAV;EFNA4
  • Influenza A virus
  • Influenza A virus
  • 6
  • EGFR;ANXA5;CACNA1C;CLEC4M;CD209;UVRAG
  • Lassa mammarenavirus
  • Lassa mammarenavirus
  • 7
  • LAMP1;AXL;TYRO3;DAG1;CLEC4G;CD209;HAVCR1
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • DevSig
  • DevSig
  • 500
  • AAED1;ABI3;AC020909.2;ACBD7;ACOT9;ACP5;ACSL5;ACTA2;ACTC1;ADAMTS1;ADAMTS4;ADARB2;...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • DrugTarSig
  • DrugTarSig
  • 854
  • ABAT;ABCA1;ABCC1;ABCC2;ABCC8;ABCC9;ABL1;ACAT1;ACE;ACHE;ACLY;ACP3;ACTN1;ADA;ADH1A...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • TFsig
  • TFsig
  • 1657
  • ATF1;SOX3;SPIB;ZNF620;ZNF225;HOXD13;NR1D1;FOXJ3;ZBED3;BCL6B;HAND2;ZNF576;TBX3;FO...
  • AP-2
  • TFsig
  • 5
  • TFAP2E;TFAP2C;TFAP2B;TFAP2A;TFAP2D
  • DACH
  • TFsig
  • 2
  • DACH1;DACH2
  • HSF
  • TFsig
  • 10
  • HSFX3;HSF5;HSFX1;HSFY2;HSFY1;HSF1;HSFX4;HSF4;HSF2;HSFX2
  • PAX
  • TFsig
  • 9
  • PAX1;PAX6;PAX7;PAX8;PAX5;PAX4;PAX2;PAX9;PAX3
  • RHD
  • TFsig
  • 10
  • NFATC3;NFATC4;NFKB2;NFKB1;NFATC1;RELA;NFAT5;NFATC2;REL;RELB
  • zf-LITAF-like
  • TFsig
  • 3
  • CDIP1;LITAF;LITAFD
  • zf-NF-X1
  • TFsig
  • 2
  • NFXL1;NFX1
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • LongevityMap
  • LongevityMap: Genetic association studies of longevity
  • 274
  • APOC3;APOE;ACE;APOB;APOE;APOE;APOB;ACE;APOC1;SERPINE1;HLA-DRB1;ACE;SULT1A1;TH;GS...
  • The Ageing Gene Database
  • GenAge: The Ageing Gene Database
  • 2205
  • aak-2;aat-8;abu-11;acl-11;aco-2;Adcy5;age-1;AGP1;ain-1;akt-1;alg-2;amt-2;Arhgap1...
  • GenDR
  • GenDR: The GenDR Database of Dietary Restriction-Related Genes
  • 215
  • SIR2;CDC25;HAP4;PNC1;CYT1;SCH9;Mdh2;NPT1;RPD3;HST2;TOR1;LAT1;Gdh;MSN2;MSN4;NDE1;...
  • CellAge
  • CellAge: The Database of Cell Senescence Genes
  • 949
  • AAK1;ABCB1;ABCC6;ABI3;ABI3BP;ACER2;ACER2;ACKR1;ACLY;ADCK5;AGO2;AGR2;AGT;AHR;AKAP...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • Pain
  • Pain_17
  • 17
  • KCNS1;SCN9A;ADRB2;H2TRA;CACNG2;IL16;COMT;OPRM1;TRPV1;MC1R;GCH1;CACNA2D3;CYP2D6;A...
  • Pain
  • Pain_27
  • 27
  • TRPV1;TRPV2;TRPV3;TRPV4;P2X3;P2X4;P2X7;TRPM8;TRPA1;P2RY3;P2RY7;BDKRB1;BDKRB2;Htr...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • HypoxiaGenes
  • HypoxiaGenes
  • 25
  • ANKRD37;NDRG1;BNIP3;P4HA1;DDIT4;VEGFA;FAM162A;SLC2A1;P4HA2;PDK1;AK4;PGK1;EGLN3;A...
  • HALLMARK_HYPOXIA
  • HALLMARK_HYPOXIA
  • 200
  • ADM;ADORA2B;AK4;AKAP12;ALDOA;ALDOB;ALDOC;AMPD3;ANGPTL4;ANKZF1;ANXA2;ATF3;ATP7A;B...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • HumanSpecificGenes11
  • HumanSpecificGenes11
  • 11
  • ARHGAP11B;FAM72B;GTF2IP1;FAM72B;FAM72C;GTF2IRD2B;NBPF14;NOTCH2NLB;NOTCH2NLA;SRGA...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • CircadianGeneHarmonizome
  • 11 proteins participating in the circadian rhythm pathway from the KEGG Pathways dataset.
  • 11
  • ARNTL;CLOCK;CRY1;CRY2;CSNK1D;CSNK1E;NPAS2;NR1D1;PER1;PER2;PER3
  • CircadianGeneDatabase
  • CircadianGeneDatabase
  • 576
  • MT-CO1;C21orf91;SLC15A1;FOXO1;IRS2;NDUFV3;PHLPP1;AMELX;ASMT;KCNB1;PTGIS;PEBP4;EG...
  • CircadianGene2019_CircaDB_MSigDB
  • Circadian-related genes
  • 2091
  • ADA;C1QTNF7;CACNA2D2;CELF2;CLOCK;DIXDC1;EPHX1;FAT1;GIMAP5;HERPUD1;ICOS;KCNMA1;MI...
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  • Type
  • Remark
  • GeneNum
  • GeneList
  • PrimateSpecificGenes_13
  • PrimateSpecificGenes
  • 13
  • AK023372;ZNF843;TPRX1;EFJ3;ANRKD16;QBEL1;GOLGA6L5;C8orf79;CXORF45;USP40;NAG4;FAS...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • Neurotransmitters
  • Neurotransmitters
  • 48
  • CACNG3;CACNG2;CRH;CRHBP;GSG1L;CNIH3;ADRB2;DAPK1;DLG4;EPHB2;PTK2B;DLGAP4;NLGN1;AR...
  • SynapticGenes
  • SynapticGenes
  • 174
  • ASIC2;AKAP5;AKAP9;ALDH9A1;AMPH;APBA1;APOE;ATXN3;BAIAP3;BSN;CACNA1B;CACNA1E;CALY;...
  • IonChannelTransporters
  • IonChannelTransporters
  • 183
  • CLCN6;CLCA1;CLCA4;ATP2C1;ATP1A2;ATP6V0A1;BEST2;ATP6V1H;ANO2;NEDD4L;ATP9A;MCOLN3;...
  • Neuropeptides
  • Neuropeptides
  • 64
  • ADCYAP1;ADM;ADM2;AGRP;AGT;APLN;AVP;CALCA;CALCB;CCK;CHGA;CRH;GAL;GALP;GAST;GHRH;G...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • InnateImmunityGenes
  • InnateImmunityGenes
  • 1319
  • COLEC12;YES1;NRIP1;BID;APP;PTPN2;GATA6;HRH4;CRKL;IFNAR2;IFNAR1;IFNGR2;MAPK1;RNF1...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • Obesity_14
  • Obesity
  • 14
  • ADCY3;AGRP;BDNF;KSR2;LEP;LEPR;MC4R;MRAP2;NTRK2;PHIP;POMC;SH2B1;SIM1
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • CellCycleGenes.S
  • Genes associated with S-phase
  • 43
  • MCM5;PCNA;TYMS;FEN1;MCM2;MCM4;RRM1;UNG;GINS2;MCM6;CDCA7;DTL;PRIM1;UHRF1;MLF1IP;H...
  • CellCycleGenes.G2M
  • Genes associated with G2M-phase
  • 54
  • HMGB2;CDK1;NUSAP1;UBE2C;BIRC5;TPX2;TOP2A;NDC80;CKS2;NUF2;CKS1B;MKI67;TMPO;CENPF;...
  • Cytokines
  • Cytokines
  • 1193
  • IL4;SOCS1;IL10;IL12B;IL1B;CRLF1;IL13;IL17F;IL15;CLCF1;IL1A;IL6ST;SOCS2;SOCS6;IL1...
  • ChemokineLigands
  • ChemokineLigands
  • 45
  • CCL1;CCL2;CCL3;CCL3L1;CCL3L3;CCL4;CCL4L1;CCL4L2;CCL5;CCL7;CCL8;CCL11;CCL13;CCL14...
  • GOCC_CILIARY_BASAL_BODY
  • GOCC_CILIARY_BASAL_BODY
  • 173
  • HDAC6;TOPORS;SPAG5;CENPF;CETN2;CETN3;TBC1D7;SDCCAG8;ENTR1;SPACA9;RABL2B;CEP250;I...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • UltraConservedGenes
  • UltraConservedGenes
  • 3992
  • DHX35;COG6;PIGN;KIF13A;KCNS2;EFHC1;TBC1D7;POLR3B;TAF2;LACTB;GTF2H3;DDX1;SHPRH;NS...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • MitochondriaGenes
  • ChemokineRecptors
  • 19
  • CXCR1;CXCR2;CXCR3;CXCR4;CXCR5;CXCR6;CCR1;CCR2;CCR3;CCR4;CCR5;CCR6;CCR7;CCR8;CCR9...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • SleepDisorders
  • SleepDisorders
  • 668
  • SREBF2;HPCAL1;CYR61;NQO1;TSHB;TOP2A;ADCK3;MBP;INSIG1;PON1;PSMB1;ITM2B;E2F1;BMP4;...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • StressResponse
  • Genes annotated by the GO term GO:0006950. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
  • 210
  • ABCF1;ABL1;ACHE;ACVRL1;ADM;ADORA1;ADORA2A;ADORA3;AFAP1L2;AGER;AHR;AHSA1;AHSG;AIF...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • GlycoGene_GGDB
  • GlycoGene
  • 222
  • ST3GAL2;GALNT4;SLC35B4;HS3ST3A1;B3GALNT1;GALNT13;PIGT;GALNT9;B4GALNT3;GALNT14;SL...
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • AutoImmune
  • AutoImmune
  • 5
  • AIRE;FOXP3;FAS;PI3K;CTLA4
  • Select
  • Type
  • Remark
  • GeneNum
  • GeneList
  • FishGenes
  • FishUpRegulatingGenes
  • 91
  • si:ch211-225b11.1;si:ch211-266g18.6;ctsl.1;anos1b;pde11al;si:ch211-107o10.3;lpar...
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