This work was supported by Natural Science Foundation of Jiangsu Province [BK20220279]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-I2M-1-061, 2022-I2M-2-004]; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2022-RC416-01]; NCTIB Fund for R&D Platform for Cell and Gene Therapy, the Suzhou Municipal Key Laboratory [SZS2022005]; Gusu Innovation and Entrepreneurship Leading Talents Program [ZXL2022475]. Funding for open access charge: CAMS Innovation Fund for Medical Sciences (CIFMS).
We thank High-throughput sequencing and high-performance computing platform , Laboratory Animal Science Center of ISM for technical support.
We thank Professor Wuping Ge, Professor Shunping He and Professor Gang Cao, Professor Jianwei Jiao, Professor Yuanqing He, Professor Aiping Wu, Dr Wenjie Zhu for insightful discussions and inspiring suggestions.
