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ParkinsonNet
ParkinsonNet provides a detailed view of interaction networks involved in Parkinson's disease, highlighting connections between key genes, proteins, and cellular pathways. It aids researchers in identifying potential therapeutic targets by mapping disease-specific regulatory mechanisms.
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Card
Association
Regulation
Dissecting
DissectEvo
Embryo_sc
Embryo_st
RatingList
SpeciesDyn
PathologyDyn
EmbryogenesisDyn
AnatomyDyn
RegionDyn
SpaceDyn
ExternalLink
NaviA2Z
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Part01: Card information and Cellular communication (cell2cell network)
  • Dataset information
  • Cellular communications
  • C2C conservation
  • Cellular crosstalk
  • Signaling pathway
  • Ligand-receptor
View ligand-receptor mediated cellular communications
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  • Source
  • Target
  • Ligand
  • Receptor
  • Prob
  • Pval
  • Interaction Name
  • Interaction Name 2
  • Pathway_name
  • Annotation
  • Evidence
Conservation of C2C
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    Part02: Assessment of PPI (protein-protein interaction network)
    • Association
    Part03: Regulatory network
    • G2G
    • Genetic regulatory networks
    • GO term
    • Regulon shiny
    • CellType
    • CellType
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      Part04: Dissecting receptor expression patterns (PCR, Pathogen and cell receptor mediated network)
      • Dissecting
      View virus and host information
      Virus information

      Virus:Coxsackievirus A9

      Family:Picornaviridae

      Host:Homo sapiens (Human)

      Target Gene:ITGB3,ITGAV,ITGB6

      Dataset information

      BSID: BS0001749

      Classification: Mammals

      CommonName: Human

      LatinName: Homo sapiens

      BrainRegion: Substantia nigra pars compacta

      Timing: 75 years old;82 years old;90 years old;76 years old;83 years old;78 years old

      Diseases: Parkinson's disease

      Tech: Chromium v3

      CellNum: 160883

      Title: Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson's disease

      Journal: Nature Neuroscience

      PMID: 35513515

      Matrix Download : Click to download

      Shinycell: View data

      • All Target Gene
      • ITGB3
      • ITGAV
      • ITGB6

      Virus target gene expression

      View expression summary
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      • VirusID
      • Virus
      • Gene
      • Celltype
      • MeanExpression

      Virus target gene expression

      mRNA expression of ITGB3 in human tissues [NCBI]

      Protein expression of ITGB3 in human tissues [Proteinatlas]

      Virus target gene expression

      mRNA expression of ITGAV in human tissues [NCBI]

      Protein expression of ITGAV in human tissues [Proteinatlas]

      Virus target gene expression

      mRNA expression of ITGB6 in human tissues [NCBI]

      Protein expression of ITGB6 in human tissues [Proteinatlas]

      Part05: Dissecting gene expression patterns across species during evolution
      • Gene expression patterns
      Part06: Embryo atlas and gene expression dynamics at single-cell resolution
      • scEggMuGA
      Gene list
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      • GeneSymbol
      • EnsembllD
      • GeneCard Link
      • NCBI Link
      • Ensembl Link
      • UniProt Link
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        Part07: Embryo atlas and gene expression dynamics at spatial resolution
        • stEggMuGA
        Gene list
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        • GeneSymbol
        • EnsembllD
        • GeneCard Link
        • NCBI Link
        • Ensembl Link
        • UniProt Link
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          Part08: Rating of gene list by ToppGene and Poster enrichment
          • ToppGene enrichment
          • Poster enrichment
          • Gene list
          • ToppGene enrichment
          • PPI
          • Motif enrichment

          Celltype: cell type; Symbol: gene symbol; p_val: p value; avg_log2FC: average logfc between two groups; p_val_adj: adjusted p-value;

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            Toppgen enrichment analysis of genelist
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              • Category
              • ID
              • Name
              • PValue
              • QValueFDRBH
              • QValueFDRBY
              • Detail

              Mode 1: select BSID
              {{ tabName }}
              • Classification
              • Species
              • Tissue
              Dataset information

              BSID: {{dataInfo.BSID}}

              Classification: {{dataInfo.Classification}}

              CommonName: {{dataInfo.CommonName}}

              LatinName: {{dataInfo.LatinName}}

              BrainRegion:{{dataInfo.Region}}

              Timing:{{dataInfo.Timing}}

              Diseases: {{dataInfo.Diseases}}

              Tech: {{dataInfo.Diseases}}

              CellNum: {{dataInfo.Tech}}

              Title: {{dataInfo.Title}}

              Journal: {{dataInfo.Journal}}

              PMID: {{dataInfo.PMID}}

              Matrix Download : Click to download

              Shinycell: View data

              Mode 2: select gene list
              • Gene List
              • scRNASeq
              • Spatial Transcriptomics
              Input Genes
              Choose a subsection
              • Dimensions
              Enter your own Gene symbols
              Only .csv and .h5ad file types accepted for online analysis. Download Demo (Detail of Demo dataset ).
              Only .csv and .h5ad file types accepted for online analysis. Download Demo (Detail of Demo dataset ).
              Top 10 Enriched Dimensions
                Top 30 Enriched Dimensions
                List of Enriched Dimensions
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                • Tag
                • Intersect gene num
                • p val
                • p val adj
                Part09: SpeciesDyn
                • SpeciesDyn
                Gene list
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                • GeneSymbol
                • EnsembllD
                • GeneCard Link
                • NCBI Link
                • Ensembl Link
                • UniProt Link
                • Species
                Part10: PathologyDyn
                • PathologyDyn
                Gene list
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                • GeneSymbol
                • EnsembllD
                • GeneCard Link
                • NCBI Link
                • Ensembl Link
                • UniProt Link
                • Diz
                Part11: EmbryogenesisDyn
                • EmbryogenesisDyn
                Gene list
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                • GeneSymbol
                • EnsembllD
                • GeneCard Link
                • NCBI Link
                • Ensembl Link
                • UniProt Link
                • Devo
                Part12: AnatomyDyn
                • AnatomyDyn
                Gene list
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                • GeneSymbol
                • EnsembllD
                • GeneCard Link
                • NCBI Link
                • Ensembl Link
                • UniProt Link
                • Tissue
                Part13: RegionDyn
                • RegionDyn
                Gene list
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                • GeneSymbol
                • EnsembllD
                • GeneCard Link
                • NCBI Link
                • Ensembl Link
                • UniProt Link
                • Region
                Part14: SpaceDyn
                • SpaceDyn
                Gene list
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                • GeneSymbol
                • EnsembllD
                • GeneCard Link
                • NCBI Link
                • Ensembl Link
                • UniProt Link
                • Space
                The geneset you selected is:
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                • Species
                • Tissue
                • Devo
                • Diz
                View gene expression profiles of different chips
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                  Part15: ExternalLink
                  • ExternalLink
                  Part16: NaviA2Z
                  • NaviA2Z
                    Part17: Download
                    • Download
                      Card
                      Association
                      Regulation
                      Dissecting
                      DissectEvo
                      Embryo_sc
                      Embryo_st
                      RatingList
                      SpeciesDyn
                      PathologyDyn
                      EmbryogenesisDyn
                      AnatomyDyn
                      RegionDyn
                      SpaceDyn
                      ExternalLink
                      NaviA2Z
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