Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.773e-10	-22.45	cerebellum	COSMIC cancer mutations	cerebellum	769	16	16828	48	NPAS3,CTNND2,CPE,PLCB1,HPSE2,GPC5,RYR3,NTRK2,ABLIM1,NRXN1,PRKG1,NRG3,NEBL,LRP1B,PARD3,PTPRZ1
1.932e-10	-22.37	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	15	16828	48	PRKG1,NRXN1,NEBL,LRP1B,NRG3,PTPRZ1,PARD3,NPAS3,CTNND2,CPE,PLCB1,HPSE2,ABLIM1,NTRK2,RYR3
1.973e-10	-22.35	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	15	16828	48	NPAS3,CTNND2,CPE,HPSE2,PLCB1,NTRK2,ABLIM1,RYR3,PRKG1,NRXN1,LRP1B,NEBL,NRG3,PTPRZ1,PARD3
1.996e-09	-20.03	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	13	16828	48	LSAMP,CTNND2,SOX5,NKAIN3,PLCB1,GPC5,GPM6A,RYR3,PRKG1,LRP1B,NRG3,FMN2,ADCY2
4.059e-09	-19.32	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	30	16828	48	ATP13A4,CTNND2,NKAIN3,PLCB1,RYR3,SLC1A2,MGAT4C,GPM6A,SLC4A4,SPON1,PRKG1,NFIA,TNIK,NEBL,NRG3,ADCY2,CPE,SOX5,LSAMP,HPSE2,GPC5,NTRK2,GLIS3,NRXN1,LRP1B,AHCYL1,PARD3,PTPRZ1,RORA,FMN2
4.059e-09	-19.32	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	30	16828	48	PTPRZ1,PARD3,FMN2,RORA,GLIS3,NRXN1,AHCYL1,LRP1B,HPSE2,GPC5,NTRK2,LSAMP,SOX5,CPE,ADCY2,NFIA,PRKG1,NEBL,NRG3,TNIK,PLCB1,NKAIN3,GPM6A,SPON1,SLC4A4,MGAT4C,SLC1A2,RYR3,ATP13A4,CTNND2
5.608e-09	-19.00	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	31	16828	48	CDH20,ADCY2,DTNA,NEBL,NRG3,TNIK,ATP1A2,PRKG1,EFEMP1,SPON1,GPM6A,RYR3,SLC1A2,NKAIN3,SPARCL1,PLCB1,AQP4,CTNND2,ATP13A4,FMN2,TRPS1,RORA,PARD3,LRP1B,CLU,NTRK2,GPC5,HPSE2,LSAMP,CPE,SOX5
9.808e-09	-18.44	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	16	19454	50	SORBS1,AQP4,LSAMP,CPE,SLC4A4,TRPM3,APOE,PLCB1,TRPS1,CLU,ATP1A2,PTPRZ1,SPARCL1,GPM6A,MSI2,ABLIM1
1.048e-08	-18.37	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	17	16828	48	NPAS3,SOX5,LSAMP,DCLK2,HPSE2,NKAIN3,SLC1A2,RYR3,NTRK2,NFIA,ATP1A2,PRKG1,TNIK,NRG3,LRP1B,PARD3,ADCY2
1.048e-08	-18.37	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	17	16828	48	PRKG1,NFIA,ATP1A2,LRP1B,NRG3,TNIK,PARD3,ADCY2,NPAS3,LSAMP,SOX5,NKAIN3,HPSE2,DCLK2,NTRK2,RYR3,SLC1A2
1.069e-08	-18.35	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	44	16828	48	TRPM3,SOX5,HPSE2,PITPNC1,ABLIM1,NTRK2,SORBS1,GLIS3,NRXN1,LRP1B,FMN2,TRPS1,RORA,RFX4,NKAIN3,SPARCL1,DCLK2,EFEMP1,SLC4A4,GPM6A,RYR3,SLC1A2,PRKG1,NFIA,NRG3,TNIK,DTNA,ADCY2,LSAMP,CPE,GPC5,CLU,AHCYL1,PTPRZ1,PARD3,NPAS3,ATP13A4,CTNND2,PLCB1,SPON1,MSI2,NEBL,APOE,CDH20
1.199e-08	-18.24	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	19	16828	48	RORA,ADCY2,FMN2,PARD3,AHCYL1,LRP1B,NEBL,NRG3,PRKG1,RYR3,NTRK2,SPON1,GPC5,HPSE2,PLCB1,NKAIN3,CTNND2,SOX5,LSAMP
1.199e-08	-18.24	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	19	16828	48	PRKG1,LRP1B,NEBL,NRG3,AHCYL1,PARD3,FMN2,ADCY2,RORA,LSAMP,SOX5,CTNND2,NKAIN3,PLCB1,GPC5,HPSE2,NTRK2,SPON1,RYR3
1.470e-08	-18.04	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	22	16828	48	ATP13A4,NPAS3,RFX4,CTNND2,SOX5,CPE,LSAMP,GPC5,HPSE2,PLCB1,NKAIN3,SLC1A2,RYR3,GPM6A,SPON1,NTRK2,PRKG1,LRP1B,NRG3,PARD3,ADCY2,FMN2
1.470e-08	-18.04	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	22	16828	48	PRKG1,LRP1B,NRG3,PARD3,FMN2,ADCY2,RFX4,NPAS3,ATP13A4,LSAMP,CPE,CTNND2,SOX5,NKAIN3,PLCB1,GPC5,HPSE2,GPM6A,NTRK2,SPON1,RYR3,SLC1A2
1.540e-08	-17.99	nervous system development	biological process	GO:0007399	2185	22	18204	50	TNIK,PRKG1,ATP1A2,CTNND2,NTRK2,NRXN1,NRG3,GPM6A,MSI2,CLU,SOX5,NFIA,PLCB1,CTNNA2,RORA,LSAMP,DCLK2,PARD3,PTPRZ1,RFX4,SLC1A2,APOE
1.608e-08	-17.95	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	14	16828	48	ADCY2,PARD3,LRP1B,NRG3,ATP1A2,NTRK2,SLC1A2,RYR3,GPC5,PLCB1,HPSE2,NKAIN3,LSAMP,SOX5
1.623e-08	-17.94	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	17	16828	48	TNIK,AHCYL1,LRP1B,NRG3,PRKG1,ADCY2,RORA,PARD3,SOX5,CTNND2,AQP4,LSAMP,SPON1,EFEMP1,HPSE2,GPC5,NKAIN3
2.522e-08	-17.50	cell periphery	cellular component	GO:0071944	6020	35	19108	50	SPARCL1,TNIK,CLU,NKAIN3,HPSE2,SORBS1,AQP4,AHCYL1,CTNND2,LSAMP,NRXN1,APOE,TRPM3,PARD3,NTRK2,PRKG1,PTPRZ1,NRG3,FMN2,SLC4A4,ATP1A2,GPM6A,MAPK10,LRP1B,SLC1A2,CPE,DTNA,SPON1,EFEMP1,CDH20,RYR3,CTNNA2,ATP13A4,GPC5,ADCY2
2.594e-08	-17.47	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	25	16828	48	PRKG1,NRG3,NEBL,ADCY2,RFX4,ATP13A4,CTNND2,PLCB1,NKAIN3,GPM6A,SPON1,EFEMP1,SLC1A2,RYR3,LRP1B,PARD3,FMN2,TRPS1,TRPM3,LSAMP,SOX5,CPE,HPSE2,GPC5,NTRK2
2.935e-08	-17.34	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	28	16828	48	PARD3,RORA,FMN2,CLU,LRP1B,HPSE2,GPC5,CPE,SOX5,LSAMP,ADCY2,CDH20,PRKG1,ATP1A2,TNIK,NEBL,NRG3,SPARCL1,NKAIN3,PLCB1,RYR3,SLC1A2,EFEMP1,SPON1,GPM6A,ATP13A4,CTNND2,AQP4
4.877e-08	-16.84	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	15	16828	48	NRG3,LRP1B,AHCYL1,PRKG1,RORA,ADCY2,PARD3,CTNND2,SOX5,LSAMP,EFEMP1,SPON1,NKAIN3,GPC5,HPSE2
7.256e-08	-16.44	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	11	16828	48	GPC5,PLCB1,RYR3,GPM6A,ATP13A4,PRKG1,CTNND2,LSAMP,NRG3,LRP1B,TRPM3
1.534e-07	-15.69	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	21	16828	48	LSAMP,CTNND2,SOX5,SPON1,NTRK2,GPM6A,SLC1A2,RYR3,HPSE2,GPC5,PLCB1,NKAIN3,NRG3,NEBL,LRP1B,PRKG1,CDH20,FMN2,ADCY2,PTPRZ1,PARD3
1.534e-07	-15.69	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	21	16828	48	LSAMP,CTNND2,SOX5,NTRK2,GPM6A,SPON1,RYR3,SLC1A2,NKAIN3,HPSE2,GPC5,PLCB1,LRP1B,NRG3,NEBL,PRKG1,FMN2,CDH20,ADCY2,PTPRZ1,PARD3
1.781e-07	-15.54	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	21	16828	48	LSAMP,CTNND2,SOX5,SPON1,GPM6A,NTRK2,SLC1A2,RYR3,HPSE2,PLCB1,GPC5,NKAIN3,LRP1B,NRG3,NEBL,PRKG1,CDH20,FMN2,ADCY2,PTPRZ1,PARD3
2.546e-07	-15.18	system development	biological process	GO:0048731	3533	26	18204	50	CPE,TNIK,PRKG1,ATP1A2,CTNND2,NEBL,NTRK2,NRXN1,NRG3,GPM6A,MSI2,CLU,SOX5,EFEMP1,NFIA,PLCB1,CTNNA2,RORA,LSAMP,TRPS1,PARD3,DCLK2,RFX4,PTPRZ1,SLC1A2,APOE
3.141e-07	-14.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	23	16828	48	ADCY2,NRG3,NEBL,PRKG1,EFEMP1,SPON1,GPM6A,RYR3,SLC1A2,NKAIN3,PLCB1,CTNND2,RFX4,TRPS1,FMN2,PARD3,LRP1B,NTRK2,HPSE2,GPC5,LSAMP,CPE,SOX5
3.366e-07	-14.90	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	6	16828	48	NKAIN3,PLCB1,LRP1B,LSAMP,GPM6A,CTNND2
3.720e-07	-14.80	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	22	16828	48	PRKG1,TNIK,NRG3,LRP1B,PARD3,PTPRZ1,RORA,ADCY2,CDH20,FMN2,ATP13A4,CTNND2,SOX5,CPE,LSAMP,GPC5,HPSE2,PLCB1,NKAIN3,RYR3,SPON1,GPM6A
3.885e-07	-14.76	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	26	16828	48	FMN2,PTPRZ1,PARD3,LRP1B,CLU,NTRK2,PITPNC1,GPC5,HPSE2,TRPM3,LSAMP,CPE,ADCY2,DTNA,NRG3,TNIK,PRKG1,MSI2,SPON1,SLC4A4,EFEMP1,MGAT4C,RYR3,PLCB1,CTNND2,NPAS3
3.885e-07	-14.76	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	26	16828	48	CLU,LRP1B,PTPRZ1,PARD3,FMN2,LSAMP,TRPM3,CPE,HPSE2,GPC5,PITPNC1,NTRK2,PRKG1,MSI2,NRG3,TNIK,DTNA,ADCY2,NPAS3,CTNND2,PLCB1,EFEMP1,SPON1,SLC4A4,RYR3,MGAT4C
4.239e-07	-14.67	lymph_node	COSMIC cancer mutations	lymph_node	1703	18	16828	48	ATP13A4,CTNND2,SOX5,LSAMP,TRPM3,PLCB1,GPC5,RYR3,NTRK2,GPM6A,PRKG1,TNIK,NRG3,NEBL,LRP1B,PARD3,DTNA,TRPS1
4.343e-07	-14.65	nodular	COSMIC cancer mutations	nodular	1515	17	16828	48	LRP1B,NEBL,GLIS3,ATP1A2,CDH20,FMN2,PTPRZ1,CTNND2,CPE,ATP13A4,NPAS3,SLC4A4,NTRK2,ABLIM1,PLCB1,DCLK2,SPARCL1
5.321e-07	-14.45	MAPT (microtubule associated protein tau)	protein interactions	4137	948	13	19454	50	SORBS1,NEBL,SLC1A2,CTNNA2,LSAMP,APOE,TNIK,MAPK10,CTNND2,ATP1A2,CLU,ABLIM1,GPM6A
6.051e-07	-14.32	multicellular organism development	biological process	GO:0007275	3957	27	18204	50	RORA,CTNNA2,APOE,SLC1A2,PTPRZ1,RFX4,DCLK2,PARD3,TRPS1,CDH20,LSAMP,NTRK2,NRXN1,NEBL,CTNND2,ATP1A2,PRKG1,TNIK,CPE,PLCB1,NFIA,EFEMP1,CLU,SOX5,MSI2,GPM6A,NRG3
6.193e-07	-14.29	anatomical structure morphogenesis	biological process	GO:0009653	2225	20	18204	50	EFEMP1,PTPRZ1,PARD3,CLU,SOX5,ABLIM1,APOE,NFIA,GPM6A,NRG3,CDH20,CTNND2,CTNNA2,PRKG1,NTRK2,NRXN1,RORA,NEBL,CPE,TNIK
6.984e-07	-14.17	brainstem	COSMIC cancer mutations	brainstem	3102	24	16828	48	ADCY2,CDH20,PRKG1,TNIK,NRG3,PLCB1,NKAIN3,SLC1A2,RYR3,GPM6A,SPON1,ATP13A4,NPAS3,CTNND2,PARD3,PTPRZ1,RORA,FMN2,LRP1B,HPSE2,GPC5,SOX5,CPE,LSAMP
1.137e-06	-13.69	negative regulation of amyloid-beta formation	biological process	GO:1902430	29	4	18204	50	APOE,NTRK2,SPON1,CLU
1.224e-06	-13.61	plasma membrane	cellular component	GO:0005886	5538	31	19108	50	AHCYL1,AQP4,NRXN1,LSAMP,CTNND2,TNIK,HPSE2,SORBS1,NKAIN3,CTNNA2,RYR3,CDH20,SLC1A2,CPE,DTNA,LRP1B,ATP13A4,GPC5,ADCY2,PRKG1,NTRK2,NRG3,PTPRZ1,APOE,PARD3,TRPM3,MAPK10,GPM6A,FMN2,ATP1A2,SLC4A4
1.387e-06	-13.49	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	37	16828	48	ADCY2,TNIK,NRG3,NEBL,PRKG1,NFIA,RYR3,SLC1A2,GPM6A,SPON1,SLC4A4,NKAIN3,DCLK2,PLCB1,CTNND2,NPAS3,ATP13A4,RFX4,RORA,TRPS1,FMN2,PARD3,PTPRZ1,LRP1B,AHCYL1,NRXN1,GLIS3,SORBS1,ABLIM1,PITPNC1,NTRK2,GPC5,HPSE2,SOX5,CPE,LSAMP,TRPM3
1.407e-06	-13.47	cell junction	cellular component	GO:0030054	2224	19	19108	50	PTPRZ1,TNIK,CLU,NRG3,NTRK2,PLCB1,SPARCL1,PARD3,APOE,SORBS1,GPM6A,NFIA,ATP1A2,CDH20,CTNNA2,DTNA,SLC1A2,NRXN1,CTNND2
1.499e-06	-13.41	cell junction organization	biological process	GO:0034330	532	10	18204	50	NRXN1,APOE,NFIA,CTNND2,PARD3,SORBS1,CDH20,GPM6A,NRG3,SPARCL1
1.500e-06	-13.41	negative regulation of amyloid precursor protein catabolic process	biological process	GO:1902992	31	4	18204	50	SPON1,CLU,APOE,NTRK2
1.684e-06	-13.29	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	15	16828	48	NPAS3,ATP13A4,CPE,CTNND2,SPARCL1,PLCB1,DCLK2,ABLIM1,NTRK2,ATP1A2,GLIS3,LRP1B,NEBL,PTPRZ1,CDH20
1.699e-06	-13.29	neurogenesis	biological process	GO:0022008	1334	15	18204	50	APOE,NFIA,PTPRZ1,DCLK2,SOX5,CLU,PARD3,GPM6A,NTRK2,NRXN1,RORA,CTNND2,CTNNA2,PRKG1,TNIK
1.771e-06	-13.24	generation of neurons	biological process	GO:0048699	1158	14	18204	50	PARD3,SOX5,DCLK2,PTPRZ1,NFIA,APOE,GPM6A,PRKG1,CTNND2,CTNNA2,RORA,NTRK2,NRXN1,TNIK
1.926e-06	-13.16	central nervous system development	biological process	GO:0007417	995	13	18204	50	NTRK2,RORA,CTNNA2,PRKG1,ATP1A2,PLCB1,SLC1A2,PTPRZ1,RFX4,DCLK2,CLU,MSI2,NRG3
1.935e-06	-13.16	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	8	16828	48	PRKG1,SOX5,LRP1B,GPC5,NKAIN3,ADCY2,GPM6A,FMN2
1.990e-06	-13.13	cell morphogenesis	biological process	GO:0000902	687	11	18204	50	GPM6A,CDH20,PARD3,CLU,PTPRZ1,NFIA,TNIK,PRKG1,CTNND2,CTNNA2,NRXN1
2.197e-06	-13.03	negative regulation of amide metabolic process	biological process	GO:0034249	34	4	18204	50	CLU,SPON1,APOE,NTRK2
3.560e-06	-12.55	anatomical structure development	biological process	GO:0048856	5207	30	18204	50	CTNND2,PRKG1,ATP1A2,NTRK2,NRXN1,NEBL,CPE,SPARCL1,TNIK,EFEMP1,SOX5,CLU,PLCB1,NFIA,GPM6A,NRG3,MSI2,FMN2,CTNNA2,RORA,PTPRZ1,RFX4,DCLK2,ABLIM1,PARD3,APOE,SLC1A2,LSAMP,TRPS1,CDH20
4.805e-06	-12.25	neuron differentiation	biological process	GO:0030182	1081	13	18204	50	CTNNA2,CTNND2,PRKG1,NRXN1,NTRK2,RORA,TNIK,PTPRZ1,PARD3,DCLK2,APOE,NFIA,GPM6A
5.942e-06	-12.03	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	32	16828	48	CLU,SORBS1,GLIS3,LRP1B,PTPRZ1,PARD3,TRPS1,FMN2,RORA,TRPM3,LSAMP,SOX5,GPC5,HPSE2,NTRK2,NFIA,PRKG1,NEBL,NRG3,APOE,CDH20,ADCY2,NPAS3,CTNND2,AQP4,PLCB1,SPARCL1,NKAIN3,GPM6A,SPON1,SLC1A2,RYR3
7.147e-06	-11.85	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	14	16828	48	RYR3,ABLIM1,NTRK2,GPM6A,HPSE2,CTNND2,ATP13A4,ADCY2,FMN2,TRPS1,TNIK,NEBL,LRP1B,NRG3
7.147e-06	-11.85	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	14	16828	48	RYR3,ABLIM1,NTRK2,GPM6A,HPSE2,CTNND2,ATP13A4,ADCY2,FMN2,TRPS1,TNIK,LRP1B,NRG3,NEBL
8.691e-06	-11.65	trunk	COSMIC cancer mutations	trunk	3554	24	16828	48	TRPS1,PTPRZ1,PARD3,LRP1B,GLIS3,NRXN1,ABLIM1,NTRK2,HPSE2,LSAMP,CPE,SOX5,CDH20,NEBL,NRG3,ATP1A2,RYR3,MGAT4C,SPARCL1,DCLK2,PLCB1,CTNND2,NPAS3,ATP13A4
8.963e-06	-11.62	regulation of amyloid-beta formation	biological process	GO:1902003	48	4	18204	50	SPON1,CLU,NTRK2,APOE
9.764e-06	-11.54	telencephalon development	biological process	GO:0021537	276	7	18204	50	NRG3,DCLK2,ATP1A2,RFX4,SLC1A2,NTRK2,PLCB1
9.823e-06	-11.53	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	13	16828	48	ADCY2,FMN2,CDH20,PARD3,NRG3,LRP1B,PRKG1,RYR3,SLC1A2,GPC5,PLCB1,SOX5,ATP13A4
1.140e-05	-11.38	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	37	16828	48	NKAIN3,DCLK2,PLCB1,EFEMP1,SPON1,SLC4A4,GPM6A,RYR3,SLC1A2,RFX4,ATP13A4,CTNND2,APOE,CDH20,ADCY2,PRKG1,ATP1A2,NRG3,NEBL,TNIK,HPSE2,GPC5,ABLIM1,NTRK2,LSAMP,TRPM3,CPE,SOX5,PTPRZ1,PARD3,TRPS1,FMN2,RORA,CLU,GLIS3,LRP1B,AHCYL1
1.189e-05	-11.34	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	5	16828	48	NRG3,LRP1B,GPC5,PRKG1,PARD3
1.324e-05	-11.23	multicellular organismal process	biological process	GO:0032501	6177	32	18204	50	RORA,CTNNA2,RYR3,SLC1A2,APOE,PARD3,DCLK2,ABLIM1,RFX4,PTPRZ1,CDH20,TRPS1,LSAMP,NEBL,NRXN1,NTRK2,PRKG1,ATP1A2,DTNA,CTNND2,TNIK,CPE,NFIA,PLCB1,SOX5,CLU,EFEMP1,MSI2,NRG3,GPM6A,AQP4,SLC4A4
1.353e-05	-11.21	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	7	19454	50	AHCYL1,ABLIM1,TNIK,PLCB1,DTNA,PARD3,FMN2
1.400e-05	-11.18	forebrain development	biological process	GO:0030900	408	8	18204	50	NRG3,ATP1A2,PRKG1,DCLK2,RFX4,SLC1A2,NTRK2,PLCB1
1.498e-05	-11.11	Salivary secretion	KEGG pathways	hsa04970	90	5	7161	26	RYR3,ATP1A2,ADCY2,PRKG1,PLCB1
1.498e-05	-11.11	Salivary secretion	KEGG pathways	ko04970	90	5	7161	26	RYR3,ATP1A2,PRKG1,PLCB1,ADCY2
1.549e-05	-11.08	regulation of amyloid precursor protein catabolic process	biological process	GO:1902991	55	4	18204	50	APOE,NTRK2,CLU,SPON1
1.569e-05	-11.06	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	43	16828	48	CDH20,ADCY2,DTNA,APOE,NEBL,NRG3,TNIK,ATP1A2,PRKG1,NFIA,EFEMP1,GPM6A,SPON1,SLC4A4,RYR3,MGAT4C,SLC1A2,NKAIN3,DCLK2,PLCB1,CTNND2,RFX4,NPAS3,ATP13A4,TRPS1,FMN2,RORA,PTPRZ1,PARD3,LRP1B,AHCYL1,SORBS1,NRXN1,GLIS3,ABLIM1,PITPNC1,NTRK2,GPC5,HPSE2,LSAMP,TRPM3,SOX5,CPE
1.569e-05	-11.06	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	43	16828	48	LSAMP,TRPM3,SOX5,CPE,HPSE2,GPC5,ABLIM1,PITPNC1,NTRK2,SORBS1,GLIS3,NRXN1,LRP1B,AHCYL1,PTPRZ1,PARD3,TRPS1,FMN2,RORA,RFX4,NPAS3,ATP13A4,CTNND2,NKAIN3,PLCB1,DCLK2,EFEMP1,SPON1,GPM6A,SLC4A4,RYR3,SLC1A2,MGAT4C,ATP1A2,NFIA,PRKG1,NRG3,NEBL,TNIK,DTNA,APOE,CDH20,ADCY2
1.642e-05	-11.02	synapse	cellular component	GO:0045202	1473	14	19108	50	NTRK2,NRG3,CLU,PTPRZ1,TNIK,APOE,SPARCL1,PLCB1,GPM6A,ATP1A2,DTNA,SLC1A2,NRXN1,CTNND2
1.668e-05	-11.00	neuron development	biological process	GO:0048666	859	11	18204	50	APOE,PTPRZ1,PARD3,DCLK2,GPM6A,NRXN1,NTRK2,CTNND2,CTNNA2,PRKG1,TNIK
1.776e-05	-10.94	tibia	COSMIC cancer mutations	tibia	836	11	16828	48	CPE,CTNND2,TRPM3,LSAMP,PLCB1,NKAIN3,GPM6A,ABLIM1,PRKG1,TNIK,LRP1B
1.836e-05	-10.91	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	7	19454	50	NEBL,TNIK,SORBS1,ABLIM1,CTNNA2,DTNA,PARD3
2.014e-05	-10.81	pharynx	COSMIC cancer mutations	pharynx	2696	20	16828	48	RFX4,NPAS3,ATP13A4,CTNND2,GPC5,EFEMP1,PITPNC1,NTRK2,SLC4A4,RYR3,SLC1A2,CLU,ATP1A2,NFIA,SORBS1,NRG3,LRP1B,DTNA,PTPRZ1,FMN2
2.022e-05	-10.81	humerus	COSMIC cancer mutations	humerus	546	9	16828	48	PRKG1,NEBL,LRP1B,SOX5,NKAIN3,GPC5,FMN2,GPM6A,ADCY2
2.126e-05	-10.76	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	33	16828	48	ADCY2,PRKG1,ATP1A2,NEBL,NRG3,TNIK,SPARCL1,DCLK2,PLCB1,SLC4A4,SPON1,GPM6A,RYR3,MGAT4C,NPAS3,ATP13A4,CTNND2,AQP4,PTPRZ1,PARD3,TRPS1,FMN2,SORBS1,NRXN1,GLIS3,LRP1B,GPC5,HPSE2,PITPNC1,ABLIM1,TRPM3,CPE,SOX5
2.258e-05	-10.70	brain development	biological process	GO:0007420	724	10	18204	50	CTNNA2,RFX4,PRKG1,ATP1A2,DCLK2,PLCB1,NTRK2,RORA,SLC1A2,NRG3
2.334e-05	-10.67	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	9	16828	48	PRKG1,LRP1B,CTNND2,PLCB1,SLC4A4,NTRK2,TRPS1,RYR3,ADCY2
2.401e-05	-10.64	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	9	16828	48	PLCB1,NTRK2,SLC4A4,TRPS1,RYR3,ADCY2,PRKG1,LRP1B,CTNND2
2.501e-05	-10.60	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	17	16828	48	MSI2,NRG3,LRP1B,NEBL,PTPRZ1,PARD3,RBMS3,FMN2,TRPS1,RORA,TRPM3,LSAMP,AQP4,PLCB1,GPC5,GPM6A,ABLIM1
2.773e-05	-10.49	developmental process	biological process	GO:0032502	5716	30	18204	50	EFEMP1,CLU,SOX5,PLCB1,NFIA,GPM6A,NRG3,MSI2,FMN2,CTNND2,ATP1A2,PRKG1,NTRK2,NRXN1,NEBL,SPARCL1,CPE,TNIK,PTPRZ1,RFX4,DCLK2,ABLIM1,PARD3,APOE,SLC1A2,LSAMP,TRPS1,CDH20,CTNNA2,RORA
3.271e-05	-10.33	synapse organization	biological process	GO:0050808	333	7	18204	50	SPARCL1,NRG3,GPM6A,NFIA,NRXN1,APOE,CTNND2
3.419e-05	-10.28	sarcolemma	cellular component	GO:0042383	142	5	19108	50	PRKG1,RYR3,AQP4,DTNA,ATP1A2
3.935e-05	-10.14	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	46	16828	48	TNIK,NRG3,NFIA,PRKG1,ADCY2,DTNA,RFX4,SLC1A2,MGAT4C,RYR3,SLC4A4,GPM6A,EFEMP1,DCLK2,SPARCL1,NKAIN3,LRP1B,NRXN1,GLIS3,SORBS1,RORA,TRPS1,FMN2,SOX5,TRPM3,NTRK2,ABLIM1,PITPNC1,HPSE2,NEBL,MSI2,ATP1A2,CDH20,CTNND2,AQP4,ATP13A4,NPAS3,SPON1,PLCB1,AHCYL1,CLU,PARD3,PTPRZ1,CPE,LSAMP,GPC5
3.986e-05	-10.13	scalp	COSMIC cancer mutations	scalp	2110	17	16828	48	SLC4A4,GPC5,PLCB1,LSAMP,SOX5,ATP13A4,FMN2,TRPS1,RORA,PTPRZ1,RBMS3,NEBL,PRKG1,NFIA,SORBS1,ATP1A2,NRXN1
3.991e-05	-10.13	head development	biological process	GO:0060322	774	10	18204	50	NRG3,PLCB1,NTRK2,SLC1A2,RORA,CTNNA2,RFX4,DCLK2,PRKG1,ATP1A2
3.994e-05	-10.13	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	10	16828	48	CTNND2,SOX5,NEBL,LRP1B,PRKG1,NTRK2,TRPS1,PARD3,PLCB1,DTNA
4.464e-05	-10.02	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	30	16828	48	HPSE2,GPC5,NTRK2,TRPM3,LSAMP,SOX5,PTPRZ1,PARD3,TRPS1,FMN2,SORBS1,CLU,LRP1B,PLCB1,NKAIN3,SPON1,SLC4A4,GPM6A,MGAT4C,RYR3,ATP13A4,NPAS3,CTNND2,DTNA,CDH20,ADCY2,ATP1A2,PRKG1,NRG3,NEBL
4.464e-05	-10.02	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	30	16828	48	HPSE2,GPC5,NTRK2,SOX5,LSAMP,TRPM3,PARD3,PTPRZ1,TRPS1,FMN2,SORBS1,CLU,LRP1B,NKAIN3,PLCB1,RYR3,MGAT4C,SPON1,GPM6A,SLC4A4,NPAS3,ATP13A4,CTNND2,DTNA,ADCY2,CDH20,PRKG1,ATP1A2,NEBL,NRG3
4.604e-05	-9.99	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	5	16828	48	LRP1B,NRG3,PARD3,GPC5,PRKG1
4.755e-05	-9.95	face	COSMIC cancer mutations	face	2139	17	16828	48	RORA,FMN2,TRPS1,RBMS3,PARD3,PTPRZ1,NEBL,NRG3,LRP1B,MSI2,ABLIM1,GPM6A,GPC5,PLCB1,AQP4,LSAMP,TRPM3
4.882e-05	-9.93	neuron projection morphogenesis	biological process	GO:0048812	486	8	18204	50	NRXN1,PARD3,PRKG1,CTNND2,CTNNA2,PTPRZ1,TNIK,GPM6A
5.246e-05	-9.86	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	8	18204	50	PRKG1,PARD3,PTPRZ1,CTNND2,CTNNA2,NRXN1,GPM6A,TNIK
5.634e-05	-9.78	cell projection morphogenesis	biological process	GO:0048858	496	8	18204	50	NRXN1,TNIK,GPM6A,CTNNA2,CTNND2,PTPRZ1,PARD3,PRKG1
5.671e-05	-9.78	mouth	COSMIC cancer mutations	mouth	9004	39	16828	48	NTRK2,ABLIM1,PITPNC1,HPSE2,GPC5,TRPM3,LSAMP,SOX5,FMN2,TRPS1,RORA,PTPRZ1,PARD3,LRP1B,CLU,SORBS1,NRXN1,GPM6A,SPON1,SLC4A4,EFEMP1,SLC1A2,MGAT4C,RYR3,PLCB1,DCLK2,CTNND2,RFX4,ATP13A4,NPAS3,CDH20,ADCY2,DTNA,APOE,NRG3,NEBL,TNIK,PRKG1,ATP1A2
6.112e-05	-9.70	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	24	16828	48	ADCY2,NEBL,TNIK,ATP1A2,PRKG1,NFIA,SLC4A4,GPM6A,SLC1A2,RYR3,PLCB1,AQP4,CTNND2,RFX4,NPAS3,TRPS1,FMN2,PTPRZ1,PARD3,AHCYL1,LRP1B,GLIS3,NTRK2,PITPNC1
6.138e-05	-9.70	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	24	16828	48	NPAS3,RFX4,AQP4,CTNND2,PLCB1,SLC1A2,RYR3,GPM6A,SLC4A4,ATP1A2,PRKG1,NFIA,TNIK,NEBL,ADCY2,NTRK2,PITPNC1,GLIS3,AHCYL1,LRP1B,PARD3,PTPRZ1,FMN2,TRPS1
7.047e-05	-9.56	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	6	16828	48	NRG3,ADCY2,HPSE2,GPC5,NFIA,NPAS3
7.047e-05	-9.56	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	6	16828	48	NRG3,NPAS3,NFIA,ADCY2,GPC5,HPSE2
7.103e-05	-9.55	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	24	16828	48	SLC1A2,RYR3,GPM6A,SLC4A4,PLCB1,AQP4,CTNND2,NPAS3,RFX4,ADCY2,TNIK,NEBL,ATP1A2,PRKG1,NFIA,NTRK2,PITPNC1,TRPS1,FMN2,PARD3,PTPRZ1,AHCYL1,LRP1B,GLIS3
7.169e-05	-9.54	regulation of amide metabolic process	biological process	GO:0034248	81	4	18204	50	NTRK2,APOE,SPON1,CLU
7.355e-05	-9.52	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	2	18204	50	APOE,CLU
8.496e-05	-9.37	mucosal	COSMIC cancer mutations	mucosal	2009	16	16828	48	ATP13A4,CTNND2,CPE,SPARCL1,PLCB1,ABLIM1,EFEMP1,MGAT4C,SORBS1,ATP1A2,LRP1B,NRG3,NEBL,PARD3,FMN2,RORA
8.496e-05	-9.37	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	16	16828	48	PLCB1,SPARCL1,MGAT4C,EFEMP1,ABLIM1,ATP13A4,CPE,CTNND2,PARD3,RORA,FMN2,SORBS1,ATP1A2,LRP1B,NRG3,NEBL
9.242e-05	-9.29	glutamatergic synapse	cellular component	GO:0098978	412	7	19108	50	GPM6A,TNIK,NRG3,APOE,PLCB1,SPARCL1,SLC1A2
9.276e-05	-9.29	extracellular matrix	cellular component	GO:0031012	559	8	19108	50	EFEMP1,SPON1,CLU,PTPRZ1,APOE,SPARCL1,HPSE2,GPC5
9.392e-05	-9.27	external encapsulating structure	cellular component	GO:0030312	560	8	19108	50	GPC5,HPSE2,APOE,SPARCL1,SPON1,EFEMP1,PTPRZ1,CLU
9.850e-05	-9.23	neuron projection development	biological process	GO:0031175	693	9	18204	50	APOE,NRXN1,PARD3,PRKG1,CTNND2,CTNNA2,PTPRZ1,TNIK,GPM6A
1.044e-04	-9.17	learning or memory	biological process	GO:0007611	276	6	18204	50	PTPRZ1,ATP1A2,NRXN1,PLCB1,NTRK2,APOE
1.107e-04	-9.11	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	33	16828	48	ABLIM1,PITPNC1,GPC5,SOX5,TRPM3,LSAMP,RORA,TRPS1,FMN2,PARD3,PTPRZ1,LRP1B,NRXN1,SORBS1,MGAT4C,SLC1A2,RYR3,SPON1,GPM6A,SLC4A4,DCLK2,PLCB1,CTNND2,ATP13A4,RFX4,ADCY2,CDH20,DTNA,TNIK,NEBL,NRG3,PRKG1,ATP1A2
1.122e-04	-9.10	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	4	19454	50	SPARCL1,DCLK2,CLU,AHCYL1
1.125e-04	-9.09	Bile secretion	KEGG pathways	ko04976	71	4	7161	26	SLC4A4,ATP1A2,ADCY2,AQP4
1.125e-04	-9.09	Bile secretion	KEGG pathways	hsa04976	71	4	7161	26	ADCY2,AQP4,SLC4A4,ATP1A2
1.171e-04	-9.05	collagen-containing extracellular matrix	cellular component	GO:0062023	428	7	19108	50	GPC5,CLU,PTPRZ1,EFEMP1,SPON1,SPARCL1,APOE
1.245e-04	-8.99	cell junction assembly	biological process	GO:0034329	285	6	18204	50	NRXN1,CDH20,GPM6A,PARD3,NRG3,SORBS1
1.293e-04	-8.95	adherens junction	cellular component	GO:0005912	188	5	19108	50	CTNND2,PARD3,CTNNA2,SORBS1,CDH20
1.420e-04	-8.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	13	16828	48	CTNND2,TNIK,TRPM3,LRP1B,LSAMP,NRXN1,SORBS1,RYR3,SLC4A4,FMN2,TRPS1,PARD3,GPC5
1.469e-04	-8.83	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	4	19454	50	SORBS1,CLU,SPARCL1,ABLIM1
1.558e-04	-8.77	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	30	16828	48	NRXN1,GLIS3,CLU,SORBS1,LRP1B,AHCYL1,PARD3,PTPRZ1,FMN2,TRPS1,TRPM3,HPSE2,GPC5,ABLIM1,NTRK2,NFIA,ATP1A2,PRKG1,NRG3,NEBL,DTNA,ADCY2,CDH20,ATP13A4,RFX4,SPARCL1,PLCB1,MGAT4C,GPM6A,SLC4A4
1.569e-04	-8.76	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	30	16828	48	TRPS1,FMN2,PARD3,PTPRZ1,AHCYL1,LRP1B,GLIS3,NRXN1,SORBS1,CLU,NTRK2,ABLIM1,HPSE2,GPC5,TRPM3,ADCY2,CDH20,DTNA,NRG3,NEBL,ATP1A2,PRKG1,NFIA,MGAT4C,SLC4A4,GPM6A,PLCB1,SPARCL1,ATP13A4,RFX4
1.817e-04	-8.61	signaling	biological process	GO:0023052	4968	26	18204	50	SPARCL1,CPE,TNIK,PRKG1,ATP1A2,DTNA,CTNND2,NRXN1,NTRK2,NRG3,FMN2,CLU,EFEMP1,NFIA,PLCB1,RYR3,PITPNC1,RORA,AHCYL1,MAPK10,SORBS1,DCLK2,PARD3,SLC1A2,APOE,ADCY2
1.963e-04	-8.54	cellular component assembly	biological process	GO:0022607	2472	17	18204	50	NRG3,AQP4,GPM6A,CDH20,FMN2,SORBS1,CLU,ABLIM1,PARD3,RFX4,SLC1A2,TRPM3,APOE,RYR3,TNIK,NEBL,NRXN1
1.996e-04	-8.52	beta-catenin binding	molecular function	GO:0008013	107	4	18094	49	CDH20,CTNND2,CTNNA2,RORA
2.048e-04	-8.49	protein import	biological process	GO:0017038	8	2	18204	50	APOE,CLU
2.059e-04	-8.49	cell development	biological process	GO:0048468	2236	16	18204	50	PARD3,DCLK2,CLU,PTPRZ1,APOE,GPM6A,FMN2,MSI2,PRKG1,CTNND2,CTNNA2,RORA,NEBL,NTRK2,NRXN1,TNIK
2.108e-04	-8.46	cell communication	biological process	GO:0007154	5010	26	18204	50	PITPNC1,AHCYL1,RORA,RYR3,PARD3,DCLK2,SORBS1,ADCY2,APOE,SLC1A2,MAPK10,DTNA,CTNND2,PRKG1,ATP1A2,NTRK2,NRXN1,CPE,SPARCL1,TNIK,EFEMP1,CLU,PLCB1,NFIA,NRG3,FMN2
2.215e-04	-8.42	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	15	16828	48	RYR3,MGAT4C,SLC4A4,GPM6A,HPSE2,PLCB1,SOX5,NPAS3,RORA,FMN2,RBMS3,TNIK,LRP1B,NEBL,NRXN1
2.241e-04	-8.40	larynx	COSMIC cancer mutations	larynx	1948	15	16828	48	NRXN1,TNIK,LRP1B,NEBL,RBMS3,RORA,FMN2,NPAS3,SOX5,PLCB1,HPSE2,MGAT4C,RYR3,SLC4A4,GPM6A
2.259e-04	-8.40	system process	biological process	GO:0003008	2015	15	18204	50	RYR3,NTRK2,NRXN1,PRKG1,ATP1A2,DTNA,CTNNA2,SLC4A4,AQP4,SLC1A2,APOE,PLCB1,ABLIM1,PTPRZ1,EFEMP1
2.294e-04	-8.38	cognition	biological process	GO:0050890	319	6	18204	50	NTRK2,PLCB1,APOE,NRXN1,ATP1A2,PTPRZ1
2.357e-04	-8.35	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	11	18204	50	GPM6A,APOE,PARD3,ABLIM1,RFX4,PTPRZ1,TNIK,NRXN1,PRKG1,CTNNA2,CTNND2
2.564e-04	-8.27	OCLN (occludin)	protein interactions	100506658	495	7	19454	50	EFEMP1,ABLIM1,NTRK2,TNIK,DTNA,PARD3,FMN2
2.663e-04	-8.23	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	33	16828	48	NFIA,PRKG1,ATP1A2,NEBL,NRG3,ADCY2,CDH20,NPAS3,ATP13A4,RFX4,AQP4,CTNND2,DCLK2,PLCB1,RYR3,SLC1A2,SPON1,SLC4A4,NRXN1,CLU,LRP1B,AHCYL1,PARD3,PTPRZ1,RORA,TRPS1,FMN2,SOX5,LSAMP,TRPM3,HPSE2,PITPNC1,NTRK2
2.663e-04	-8.23	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	33	16828	48	ADCY2,CDH20,NEBL,NRG3,ATP1A2,PRKG1,NFIA,SLC1A2,RYR3,SLC4A4,SPON1,DCLK2,PLCB1,CTNND2,AQP4,ATP13A4,NPAS3,RFX4,RORA,FMN2,TRPS1,PARD3,PTPRZ1,AHCYL1,LRP1B,NRXN1,CLU,NTRK2,PITPNC1,HPSE2,SOX5,TRPM3,LSAMP
3.281e-04	-8.02	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	50	ATP1A2,NTRK2
3.281e-04	-8.02	action potential propagation	biological process	GO:0098870	10	2	18204	50	ATP1A2,NTRK2
3.283e-04	-8.02	glial cell differentiation	biological process	GO:0010001	219	5	18204	50	NTRK2,NFIA,PTPRZ1,CLU,PARD3
3.355e-04	-8.00	cell projection organization	biological process	GO:0030030	1200	11	18204	50	GPM6A,TNIK,ABLIM1,PRKG1,PARD3,PTPRZ1,CTNND2,CTNNA2,RFX4,NRXN1,APOE
3.413e-04	-7.98	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	6	19454	50	PARD3,AHCYL1,ABLIM1,CLU,TNIK,NTRK2
3.432e-04	-7.98	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	33	16828	48	CPE,SOX5,LSAMP,ABLIM1,NTRK2,HPSE2,GPC5,LRP1B,AHCYL1,GLIS3,CLU,RORA,FMN2,PARD3,PTPRZ1,CTNND2,ATP13A4,RFX4,RYR3,MGAT4C,SLC1A2,EFEMP1,GPM6A,SPON1,SPARCL1,NKAIN3,PLCB1,TNIK,NRG3,NEBL,PRKG1,ADCY2,CDH20
3.474e-04	-7.96	Pancreatic secretion	KEGG pathways	ko04972	95	4	7161	26	ATP1A2,SLC4A4,PLCB1,ADCY2
3.474e-04	-7.96	Pancreatic secretion	KEGG pathways	hsa04972	95	4	7161	26	SLC4A4,ATP1A2,PLCB1,ADCY2
3.616e-04	-7.92	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	23	16828	48	DTNA,ADCY2,ATP1A2,NFIA,PRKG1,TNIK,PLCB1,SPARCL1,RYR3,ATP13A4,CTNND2,AQP4,PARD3,PTPRZ1,TRPS1,NRXN1,GLIS3,LRP1B,GPC5,SOX5,CPE,TRPM3,LSAMP
3.617e-04	-7.92	Circadian entrainment	KEGG pathways	ko04713	96	4	7161	26	RYR3,ADCY2,PLCB1,PRKG1
3.617e-04	-7.92	Circadian entrainment	KEGG pathways	hsa04713	96	4	7161	26	RYR3,ADCY2,PLCB1,PRKG1
3.675e-04	-7.91	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	3	10285	31	ADCY2,PLCB1,AHCYL1
3.883e-04	-7.85	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	13	16828	48	RBMS3,PTPRZ1,RORA,TRPS1,NRXN1,PRKG1,ATP1A2,PLCB1,GPC5,SLC4A4,ATP13A4,SOX5,LSAMP
3.912e-04	-7.85	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	3	10285	31	ADCY2,AHCYL1,PLCB1
3.988e-04	-7.83	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	4	19454	50	NTRK2,DTNA,PARD3,ABLIM1
4.023e-04	-7.82	CSTL1 (cystatin like 1)	protein interactions	128817	56	3	19454	50	CPE,CLU,APOE
4.146e-04	-7.79	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	50	EFEMP1,SOX5,TRPS1
4.203e-04	-7.77	PROK2 (prokineticin 2)	protein interactions	60675	12	2	19454	50	LRP1B,CPE
4.203e-04	-7.77	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	2	19454	50	APOE,CLU
4.301e-04	-7.75	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	50	FMN2,PLCB1,DTNA,PARD3,TNIK,AHCYL1,ABLIM1,MSI2
4.497e-04	-7.71	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	30	16828	48	ADCY2,ATP1A2,NFIA,PRKG1,NRG3,TNIK,DCLK2,PLCB1,SLC4A4,SPON1,RYR3,RFX4,ATP13A4,CTNND2,PTPRZ1,PARD3,FMN2,RORA,CLU,NRXN1,LRP1B,AHCYL1,HPSE2,GPC5,PITPNC1,ABLIM1,NTRK2,TRPM3,SOX5,CPE
4.497e-04	-7.71	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	30	16828	48	CTNND2,RFX4,ATP13A4,SLC4A4,SPON1,RYR3,PLCB1,DCLK2,NRG3,TNIK,ATP1A2,NFIA,PRKG1,ADCY2,TRPM3,SOX5,CPE,NTRK2,PITPNC1,ABLIM1,GPC5,HPSE2,AHCYL1,LRP1B,CLU,NRXN1,FMN2,RORA,PTPRZ1,PARD3
4.842e-04	-7.63	signal transduction	biological process	GO:0007165	4637	24	18204	50	CLU,EFEMP1,NFIA,PLCB1,NRG3,FMN2,ATP1A2,PRKG1,DTNA,CTNND2,NTRK2,CPE,SPARCL1,TNIK,DCLK2,SORBS1,PARD3,APOE,ADCY2,MAPK10,PITPNC1,RORA,AHCYL1,RYR3
4.983e-04	-7.60	bone	COSMIC cancer mutations	bone	8157	35	16828	48	CPE,SOX5,TRPM3,LSAMP,NTRK2,ABLIM1,GPC5,HPSE2,LRP1B,NRXN1,GLIS3,SORBS1,RORA,TRPS1,FMN2,PARD3,PTPRZ1,CTNND2,ATP13A4,NPAS3,RYR3,GPM6A,SPON1,SLC4A4,PLCB1,DCLK2,SPARCL1,NKAIN3,TNIK,NEBL,NRG3,PRKG1,ATP1A2,ADCY2,DTNA
5.370e-04	-7.53	neuron projection	cellular component	GO:0043005	1331	11	19108	50	SLC1A2,DTNA,CTNNA2,CTNND2,ADCY2,APOE,PARD3,NTRK2,CLU,ATP1A2,GPM6A
5.583e-04	-7.49	regulation of synapse organization	biological process	GO:0050807	246	5	18204	50	APOE,NTRK2,NRXN1,GPM6A,CTNNA2
5.657e-04	-7.48	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	2	18204	50	APOE,CLU
5.774e-04	-7.46	adenoma	COSMIC cancer mutations	adenoma	2873	18	16828	48	NPAS3,TRPM3,SOX5,CTNND2,GPC5,HPSE2,DCLK2,NTRK2,GPM6A,RYR3,PRKG1,LRP1B,NEBL,PTPRZ1,APOE,PARD3,CDH20,ADCY2
5.776e-04	-7.46	PLXNA4 (plexin A4)	protein interactions	91584	14	2	19454	50	CLU,GPM6A
5.776e-04	-7.46	C9 (complement C9)	protein interactions	735	14	2	19454	50	APOE,CLU
5.850e-04	-7.44	cellular component organization	biological process	GO:0016043	5636	27	18204	50	RYR3,AHCYL1,PITPNC1,CTNNA2,CDH20,HPSE2,SLC1A2,APOE,DCLK2,ABLIM1,SORBS1,PARD3,PTPRZ1,RFX4,TNIK,SPARCL1,NEBL,NRXN1,PRKG1,CTNND2,FMN2,NRG3,AQP4,GPM6A,NFIA,TRPM3,CLU
6.096e-04	-7.40	cellular component biogenesis	biological process	GO:0044085	2716	17	18204	50	SLC1A2,TRPM3,APOE,PARD3,SORBS1,ABLIM1,CLU,RFX4,CDH20,FMN2,NRG3,GPM6A,AQP4,NEBL,NRXN1,TNIK,RYR3
6.100e-04	-7.40	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	20	16828	48	MGAT4C,SPON1,PITPNC1,EFEMP1,GPC5,PLCB1,CTNND2,TRPM3,ATP13A4,RFX4,ADCY2,FMN2,PARD3,PTPRZ1,NRG3,NEBL,LRP1B,NRXN1,GLIS3,ATP1A2
6.107e-04	-7.40	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	23	16828	48	HPSE2,PLCB1,RYR3,NTRK2,GPM6A,SLC4A4,ATP13A4,RFX4,SOX5,CTNND2,TRPM3,PARD3,PTPRZ1,ADCY2,CDH20,FMN2,TRPS1,SORBS1,PRKG1,NFIA,TNIK,LRP1B,NRG3
6.169e-04	-7.39	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	3	10285	31	ATP1A2,AHCYL1,RYR3
6.227e-04	-7.38	regulation of synapse structure or activity	biological process	GO:0050803	252	5	18204	50	GPM6A,CTNNA2,APOE,NRXN1,NTRK2
6.545e-04	-7.33	NAKATPASE	prints domains	PR00121	9	2	5227	23	ATP1A2,ATP13A4
6.588e-04	-7.33	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	50	SLC4A4,ATP1A2
6.623e-04	-7.32	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	17	16828	48	ATP1A2,NRXN1,NEBL,NRG3,LRP1B,PTPRZ1,PARD3,TRPS1,CDH20,ATP13A4,LSAMP,CTNND2,SOX5,PLCB1,HPSE2,RYR3,MGAT4C
6.654e-04	-7.32	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	2	19454	50	CPE,CLU
6.654e-04	-7.32	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	2	19454	50	TNIK,PARD3
6.868e-04	-7.28	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	8	10285	31	SLC1A2,ATP13A4,AQP4,ATP1A2,TRPM3,SLC4A4,RYR3,ADCY2
8.233e-04	-7.10	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	32	16828	48	APOE,ADCY2,CDH20,PRKG1,ATP1A2,NEBL,NRG3,PLCB1,NKAIN3,SLC1A2,RYR3,GPM6A,SPON1,SLC4A4,EFEMP1,ATP13A4,RFX4,CTNND2,PARD3,RORA,FMN2,GLIS3,CLU,AHCYL1,LRP1B,HPSE2,GPC5,NTRK2,ABLIM1,SOX5,CPE,LSAMP
8.309e-04	-7.09	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	5	19454	50	NTRK2,SORBS1,PARD3,DTNA,PLCB1
8.382e-04	-7.08	learning	biological process	GO:0007612	154	4	18204	50	ATP1A2,NTRK2,PLCB1,NRXN1
8.440e-04	-7.08	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	5	19454	50	PARD3,SORBS1,FMN2,NEBL,PRKG1
8.536e-04	-7.07	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	39	16828	48	GPC5,HPSE2,PITPNC1,ABLIM1,NTRK2,CPE,SOX5,TRPM3,PARD3,PTPRZ1,RORA,FMN2,TRPS1,NRXN1,SORBS1,CLU,LRP1B,NKAIN3,SPARCL1,PLCB1,DCLK2,RYR3,MGAT4C,SPON1,GPM6A,SLC4A4,NPAS3,ATP13A4,RFX4,CTNND2,DTNA,CDH20,MSI2,NFIA,ATP1A2,PRKG1,TNIK,NEBL,NRG3
8.653e-04	-7.05	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	39	16828	48	DTNA,CDH20,ATP1A2,PRKG1,NFIA,MSI2,NEBL,NRG3,TNIK,PLCB1,DCLK2,SPARCL1,NKAIN3,SLC4A4,SPON1,GPM6A,MGAT4C,RYR3,RFX4,ATP13A4,NPAS3,CTNND2,PTPRZ1,PARD3,TRPS1,FMN2,RORA,SORBS1,CLU,NRXN1,LRP1B,GPC5,HPSE2,NTRK2,PITPNC1,ABLIM1,TRPM3,SOX5,CPE
8.657e-04	-7.05	asymmetric cell division	biological process	GO:0008356	16	2	18204	50	SOX5,PARD3
8.657e-04	-7.05	locomotory exploration behavior	biological process	GO:0035641	16	2	18204	50	APOE,ATP1A2
8.768e-04	-7.04	cell projection	cellular component	GO:0042995	2398	15	19108	50	GPM6A,FMN2,ATP1A2,NTRK2,CLU,APOE,ABLIM1,PARD3,NRXN1,ADCY2,CTNND2,CTNNA2,AQP4,SLC1A2,DTNA
8.927e-04	-7.02	vascular process in circulatory system	biological process	GO:0003018	273	5	18204	50	ATP1A2,PRKG1,SLC4A4,SLC1A2,APOE
9.223e-04	-6.99	gliogenesis	biological process	GO:0042063	275	5	18204	50	NTRK2,NFIA,PTPRZ1,CLU,PARD3
9.243e-04	-6.99	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	2	5310	19	PLCB1,RYR3
9.341e-04	-6.98	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	5	16828	48	APOE,CDH20,LRP1B,SOX5,RYR3
9.346e-04	-6.98	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	20	16828	48	SPARCL1,GPC5,HPSE2,ABLIM1,SLC4A4,SPON1,GPM6A,RYR3,TRPM3,CTNND2,SOX5,PTPRZ1,PARD3,FMN2,ADCY2,ATP1A2,LRP1B,NEBL,NRG3,TNIK
9.417e-04	-6.97	middle_third	COSMIC cancer mutations	middle_third	3533	20	16828	48	TNIK,NEBL,NRG3,LRP1B,ATP1A2,ADCY2,FMN2,PARD3,PTPRZ1,CTNND2,SOX5,TRPM3,RYR3,ABLIM1,SLC4A4,SPON1,GPM6A,SPARCL1,GPC5,HPSE2
9.444e-04	-6.96	cell adhesion	biological process	GO:0007155	942	9	18204	50	CDH20,SPON1,SPARCL1,LSAMP,NRXN1,SORBS1,PARD3,CTNND2,CTNNA2
9.794e-04	-6.93	regulation of amyloid fibril formation	biological process	GO:1905906	17	2	18204	50	CLU,APOE
9.794e-04	-6.93	reverse cholesterol transport	biological process	GO:0043691	17	2	18204	50	APOE,CLU
1.030e-03	-6.88	FLOT1 (flotillin 1)	protein interactions	10211	453	6	19454	50	SORBS1,FMN2,PARD3,DTNA,SOX5,ABLIM1
1.049e-03	-6.86	animal organ development	biological process	GO:0048513	2846	17	18204	50	CPE,NTRK2,RORA,NEBL,CTNNA2,ATP1A2,PRKG1,GPM6A,NRG3,PLCB1,SLC1A2,NFIA,EFEMP1,RFX4,DCLK2,ABLIM1,SOX5
1.059e-03	-6.85	regulation of cartilage development	biological process	GO:0061035	73	3	18204	50	TRPS1,EFEMP1,SOX5
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP13A4,ATP1A2
1.069e-03	-6.84	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	2	18094	49	HPSE2,APOE
1.080e-03	-6.83	prostate	COSMIC cancer mutations	prostate	13883	47	16828	48	ADCY2,DTNA,TNIK,NRG3,PRKG1,NFIA,SLC1A2,MGAT4C,RYR3,SLC4A4,GPM6A,EFEMP1,DCLK2,SPARCL1,NKAIN3,RFX4,RORA,TRPS1,FMN2,LRP1B,NRXN1,GLIS3,SORBS1,NTRK2,ABLIM1,PITPNC1,HPSE2,SOX5,TRPM3,CDH20,APOE,NEBL,MSI2,ATP1A2,SPON1,PLCB1,AQP4,CTNND2,ATP13A4,NPAS3,PARD3,PTPRZ1,AHCYL1,CLU,GPC5,CPE,LSAMP
1.088e-03	-6.82	dendrite	cellular component	GO:0030425	620	7	19108	50	ADCY2,GPM6A,ATP1A2,CTNND2,CLU,NTRK2,APOE
1.100e-03	-6.81	positive regulation of circadian rhythm	biological process	GO:0042753	18	2	18204	50	RORA,PRKG1
1.100e-03	-6.81	negative regulation of platelet activation	biological process	GO:0010544	18	2	18204	50	PRKG1,APOE
1.105e-03	-6.81	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	49	ATP13A4,ATP1A2
1.108e-03	-6.80	dendritic tree	cellular component	GO:0097447	622	7	19108	50	CLU,NTRK2,APOE,ADCY2,GPM6A,ATP1A2,CTNND2
1.112e-03	-6.80	cellular component organization or biogenesis	biological process	GO:0071840	5850	27	18204	50	NEBL,NRXN1,PRKG1,CTNND2,TNIK,SPARCL1,NFIA,TRPM3,CLU,FMN2,NRG3,GPM6A,AQP4,AHCYL1,PITPNC1,CTNNA2,RYR3,SLC1A2,APOE,PARD3,ABLIM1,SORBS1,DCLK2,RFX4,PTPRZ1,CDH20,HPSE2
1.115e-03	-6.80	astrocyte projection	cellular component	GO:0097449	19	2	19108	50	AQP4,SLC1A2
1.181e-03	-6.74	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	6	18094	49	RYR3,TRPM3,ATP1A2,SLC1A2,GPM6A,SLC4A4
1.194e-03	-6.73	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	2	19454	50	NRXN1,CTNND2
1.226e-03	-6.70	GSC (goosecoid homeobox)	protein interactions	145258	82	3	19454	50	TRPS1,SOX5,NFIA
1.227e-03	-6.70	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	2	18204	50	APOE,PRKG1
1.227e-03	-6.70	regulation of amyloid-beta clearance	biological process	GO:1900221	19	2	18204	50	CLU,APOE
1.289e-03	-6.65	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	6	18204	50	PTPRZ1,CTNNA2,CTNND2,PRKG1,PARD3,NRXN1
1.295e-03	-6.65	transporter activity	molecular function	GO:0005215	1211	10	18094	49	RYR3,TRPM3,ATP13A4,ATP1A2,SLC1A2,PITPNC1,SLC4A4,GPM6A,APOE,AQP4
1.425e-03	-6.55	behavior	biological process	GO:0007610	619	7	18204	50	ATP1A2,PTPRZ1,SLC1A2,NTRK2,APOE,PLCB1,NRXN1
1.427e-03	-6.55	somatodendritic compartment	cellular component	GO:0036477	842	8	19108	50	NRXN1,ADCY2,GPM6A,ATP1A2,CTNND2,NTRK2,CLU,APOE
1.446e-03	-6.54	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	7	18094	49	ATP13A4,ATP1A2,SLC1A2,RYR3,TRPM3,SLC4A4,GPM6A
1.446e-03	-6.54	monoatomic ion transmembrane transport	biological process	GO:0034220	804	8	18204	50	GPM6A,SLC4A4,RYR3,ATP13A4,ATP1A2,TRPM3,PLCB1,SLC1A2
1.463e-03	-6.53	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	29	16828	48	APOE,ADCY2,CDH20,PRKG1,NRG3,PLCB1,MGAT4C,SLC1A2,RYR3,GPM6A,SPON1,SLC4A4,EFEMP1,NPAS3,RFX4,CTNND2,PARD3,RORA,TRPS1,FMN2,CLU,SORBS1,LRP1B,HPSE2,GPC5,ABLIM1,PITPNC1,SOX5,TRPM3
1.473e-03	-6.52	leg	COSMIC cancer mutations	leg	969	9	16828	48	SLC4A4,FMN2,PLCB1,PTPRZ1,NRG3,LRP1B,NEBL,PRKG1,ATP13A4
1.481e-03	-6.52	contractile actin filament bundle	cellular component	GO:0097517	86	3	19108	50	ABLIM1,NEBL,SORBS1
1.481e-03	-6.52	stress fiber	cellular component	GO:0001725	86	3	19108	50	SORBS1,NEBL,ABLIM1
1.517e-03	-6.49	plasma membrane region	cellular component	GO:0098590	1278	10	19108	50	SLC1A2,PARD3,AQP4,TNIK,AHCYL1,ATP1A2,SLC4A4,GPM6A,SORBS1,NRXN1
1.545e-03	-6.47	synaptic signaling	biological process	GO:0099536	459	6	18204	50	DTNA,PLCB1,NTRK2,NRXN1,APOE,SLC1A2
1.582e-03	-6.45	TIMM10B (translocase of inner mitochondrial membrane 10B)	protein interactions	26515	23	2	19454	50	HPSE2,MSI2
1.587e-03	-6.45	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	4	18204	50	RORA,SLC4A4,SORBS1,PRKG1
1.589e-03	-6.44	regulation of sodium ion transport	biological process	GO:0002028	84	3	18204	50	AHCYL1,NKAIN3,ATP1A2
1.632e-03	-6.42	cellular response to organic cyclic compound	biological process	GO:0071407	464	6	18204	50	ADCY2,PLCB1,RORA,SLC1A2,RYR3,ATP1A2
1.637e-03	-6.41	Cation_ATPase_N	smart domains	SM00831	16	2	9717	37	ATP13A4,ATP1A2
1.644e-03	-6.41	oligodendrocyte differentiation	biological process	GO:0048709	85	3	18204	50	NTRK2,CLU,PTPRZ1
1.649e-03	-6.41	negative regulation of muscle contraction	biological process	GO:0045932	22	2	18204	50	PRKG1,ATP1A2
1.664e-03	-6.40	monoatomic cation transmembrane transport	biological process	GO:0098655	636	7	18204	50	SLC4A4,GPM6A,RYR3,ATP13A4,ATP1A2,PLCB1,TRPM3
1.680e-03	-6.39	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	14	19108	50	GPM6A,ATP1A2,FMN2,CLU,NTRK2,PARD3,ABLIM1,APOE,ADCY2,CTNND2,CTNNA2,SLC1A2,DTNA,AQP4
1.700e-03	-6.38	vascular transport	biological process	GO:0010232	86	3	18204	50	SLC1A2,SLC4A4,ATP1A2
1.700e-03	-6.38	transport across blood-brain barrier	biological process	GO:0150104	86	3	18204	50	ATP1A2,SLC4A4,SLC1A2
1.734e-03	-6.36	femur	COSMIC cancer mutations	femur	1197	10	16828	48	HPSE2,GPC5,PTPRZ1,FMN2,SPON1,SLC4A4,ADCY2,RYR3,NRG3,LRP1B
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	ATP1A2,RYR3,PARD3,DTNA
1.775e-03	-6.33	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	13	16828	48	ADCY2,FMN2,CDH20,PARD3,PTPRZ1,NEBL,LRP1B,RYR3,PITPNC1,NTRK2,PLCB1,HPSE2,ATP13A4
1.782e-03	-6.33	HS-GAG degradation	REACTOME pathways	R-HSA-2024096	21	2	10285	31	HPSE2,GPC5
1.784e-03	-6.33	extremity	COSMIC cancer mutations	extremity	1876	13	16828	48	RYR3,NTRK2,PITPNC1,PLCB1,HPSE2,ATP13A4,ADCY2,CDH20,FMN2,PARD3,PTPRZ1,NEBL,LRP1B
1.797e-03	-6.32	actomyosin	cellular component	GO:0042641	92	3	19108	50	SORBS1,NEBL,ABLIM1
1.803e-03	-6.32	relaxation of muscle	biological process	GO:0090075	23	2	18204	50	ATP1A2,PRKG1
1.813e-03	-6.31	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	4	16828	48	LRP1B,NRG3,RYR3,GPC5
1.857e-03	-6.29	cytoskeleton organization	biological process	GO:0007010	1251	10	18204	50	TNIK,FMN2,NEBL,APOE,PARD3,SORBS1,DCLK2,ABLIM1,PRKG1,CTNNA2
1.863e-03	-6.29	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	11	16828	48	ATP1A2,CLU,NFIA,FMN2,CTNND2,RFX4,ATP13A4,NTRK2,SLC4A4,PITPNC1,SLC1A2
1.863e-03	-6.29	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	11	16828	48	ATP1A2,NFIA,CLU,FMN2,CTNND2,RFX4,ATP13A4,PITPNC1,NTRK2,SLC4A4,SLC1A2
1.909e-03	-6.26	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	49	ATP1A2,ATP13A4
1.909e-03	-6.26	low-density lipoprotein particle receptor binding	molecular function	GO:0050750	24	2	18094	49	CLU,APOE
1.909e-03	-6.26	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	49	ATP1A2,ATP13A4
1.913e-03	-6.26	human chr12q21.31-q21.32	chromosome location	human chr12q21.31-q21.32	1	1	26134	50	MGAT4C
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr2q22.1-q22.2	chromosome location	human chr2q22.1-q22.2	1	1	26134	50	LRP1B
1.913e-03	-6.26	human chr10q11.23-q21.1	chromosome location	human chr10q11.23-q21.1	1	1	26134	50	PRKG1
1.913e-03	-6.26	human chr10p11.22-p11.21	chromosome location	human chr10p11.22-p11.21	1	1	26134	50	PARD3
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr4q31.23-q31.3	chromosome location	human chr4q31.23-q31.3	1	1	26134	50	DCLK2
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.987e-03	-6.22	PLCB3 (phospholipase C beta 3)	protein interactions	5331	97	3	19454	50	PARD3,PLCB1,PRKG1
2.030e-03	-6.20	actin filament bundle	cellular component	GO:0032432	96	3	19108	50	ABLIM1,NEBL,SORBS1
2.046e-03	-6.19	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	40	16828	48	ABLIM1,NTRK2,HPSE2,GPC5,CPE,SOX5,LSAMP,TRPM3,RORA,TRPS1,FMN2,PARD3,PTPRZ1,LRP1B,AHCYL1,NRXN1,CLU,SORBS1,RYR3,MGAT4C,SLC1A2,EFEMP1,SPON1,GPM6A,NKAIN3,SPARCL1,PLCB1,CTNND2,AQP4,NPAS3,ATP13A4,RFX4,ADCY2,CDH20,DTNA,TNIK,NEBL,NRG3,PRKG1,ATP1A2
2.047e-03	-6.19	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	3	19454	50	SORBS1,NTRK2,PARD3
2.062e-03	-6.18	protein tetramerization	biological process	GO:0051262	92	3	18204	50	AQP4,RYR3,TRPM3
2.067e-03	-6.18	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	16	16828	48	LRP1B,SORBS1,NFIA,GLIS3,FMN2,ADCY2,RORA,PTPRZ1,APOE,TRPM3,AQP4,CTNND2,NPAS3,SPON1,RYR3,SPARCL1
2.067e-03	-6.18	embryonal	COSMIC cancer mutations	embryonal	2659	16	16828	48	AQP4,CTNND2,TRPM3,NPAS3,RYR3,SPON1,SPARCL1,LRP1B,GLIS3,SORBS1,NFIA,RORA,ADCY2,FMN2,APOE,PTPRZ1
2.072e-03	-6.18	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	3	10285	31	AHCYL1,PLCB1,ADCY2
2.090e-03	-6.17	regulation of small molecule metabolic process	biological process	GO:0062012	331	5	18204	50	APOE,RORA,SLC4A4,PRKG1,SORBS1
2.095e-03	-6.17	high-density lipoprotein particle	cellular component	GO:0034364	26	2	19108	50	CLU,APOE
2.123e-03	-6.16	cell-cell junction	cellular component	GO:0005911	513	6	19108	50	PARD3,CDH20,CTNNA2,ATP1A2,CTNND2,SORBS1
2.130e-03	-6.15	positive regulation of amyloid precursor protein catabolic process	biological process	GO:1902993	25	2	18204	50	SPON1,CLU
2.147e-03	-6.14	Adherens junction	KEGG pathways	hsa04520	72	3	7161	26	PARD3,SORBS1,CTNNA2
2.147e-03	-6.14	Adherens junction	KEGG pathways	ko04520	72	3	7161	26	PARD3,SORBS1,CTNNA2
2.152e-03	-6.14	EGF-type_Asp/Asn_hydroxyl_site	interpro domains	IPR000152	95	3	18521	50	NRXN1,EFEMP1,LRP1B
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	ABLIM1,DTNA
2.181e-03	-6.13	HPCAL4 (hippocalcin like 4)	protein interactions	51440	27	2	19454	50	AQP4,GPM6A
2.183e-03	-6.13	intracellular signal transduction	biological process	GO:0035556	1505	11	18204	50	APOE,PLCB1,ADCY2,DCLK2,FMN2,NRG3,MAPK10,ATP1A2,PRKG1,TNIK,RYR3
2.200e-03	-6.12	EZR (ezrin)	protein interactions	7430	526	6	19454	50	DTNA,ABLIM1,SORBS1,MAPK10,TNIK,NEBL
2.238e-03	-6.10	modulation of chemical synaptic transmission	biological process	GO:0050804	494	6	18204	50	NRG3,NTRK2,APOE,PLCB1,NRXN1,ATP1A2
2.253e-03	-6.10	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	48	16828	48	CDH20,APOE,RBMS3,NEBL,ATP1A2,MSI2,SPON1,PLCB1,CTNND2,AQP4,ATP13A4,NPAS3,PTPRZ1,PARD3,AHCYL1,CLU,GPC5,LSAMP,CPE,ADCY2,DTNA,NRG3,TNIK,PRKG1,NFIA,SLC4A4,GPM6A,EFEMP1,MGAT4C,SLC1A2,RYR3,DCLK2,SPARCL1,NKAIN3,RFX4,FMN2,TRPS1,RORA,LRP1B,SORBS1,GLIS3,NRXN1,NTRK2,ABLIM1,PITPNC1,HPSE2,TRPM3,SOX5
2.261e-03	-6.09	regulation of trans-synaptic signaling	biological process	GO:0099177	495	6	18204	50	NRG3,NTRK2,APOE,PLCB1,NRXN1,ATP1A2
2.281e-03	-6.08	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	50	DTNA,CTNNA2,CDH20
2.322e-03	-6.07	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	3	7161	26	ATP1A2,ADCY2,PLCB1
2.322e-03	-6.07	Thyroid hormone synthesis	KEGG pathways	ko04918	74	3	7161	26	PLCB1,ADCY2,ATP1A2
2.393e-03	-6.04	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	22	16828	48	MGAT4C,RYR3,GPM6A,SPON1,ABLIM1,CTNND2,SOX5,TRPM3,RFX4,ADCY2,FMN2,TRPS1,PARD3,PTPRZ1,DTNA,AHCYL1,LRP1B,NRG3,GLIS3,CLU,ATP1A2,PRKG1
2.393e-03	-6.04	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	22	16828	48	GLIS3,ATP1A2,PRKG1,CLU,AHCYL1,LRP1B,NRG3,PARD3,PTPRZ1,DTNA,ADCY2,FMN2,TRPS1,RFX4,CTNND2,SOX5,TRPM3,MGAT4C,RYR3,SPON1,GPM6A,ABLIM1
2.399e-03	-6.03	calcium ion transmembrane transport	biological process	GO:0070588	205	4	18204	50	TRPM3,PLCB1,RYR3,GPM6A
2.413e-03	-6.03	Gastric acid secretion	KEGG pathways	ko04971	75	3	7161	26	ATP1A2,PLCB1,ADCY2
2.413e-03	-6.03	Gastric acid secretion	KEGG pathways	hsa04971	75	3	7161	26	ATP1A2,PLCB1,ADCY2
2.415e-03	-6.03	poly(U) RNA binding	molecular function	GO:0008266	27	2	18094	49	RBMS3,MSI2
2.512e-03	-5.99	cell differentiation	biological process	GO:0030154	3645	19	18204	50	GPM6A,MSI2,FMN2,PTPRZ1,SOX5,DCLK2,CLU,PARD3,PLCB1,APOE,NFIA,TNIK,CTNND2,CTNNA2,PRKG1,NRXN1,NTRK2,NEBL,RORA
2.514e-03	-5.99	PLEKHA6 (pleckstrin homology domain containing A6)	protein interactions	22874	29	2	19454	50	APOE,PARD3
2.537e-03	-5.98	cellular developmental process	biological process	GO:0048869	3648	19	18204	50	PTPRZ1,PARD3,SOX5,CLU,DCLK2,PLCB1,APOE,NFIA,GPM6A,FMN2,MSI2,CTNND2,CTNNA2,PRKG1,NTRK2,NRXN1,RORA,NEBL,TNIK
2.569e-03	-5.96	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	3	12186	44	APOE,CPE,GLIS3
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	App (amyloid beta precursor protein)	protein interactions	100689222	1	1	19454	50	LRP1B
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	50	NRXN1
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.593e-03	-5.95	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	44	ATP1A2,ATP13A4
2.616e-03	-5.95	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	4	7161	26	ATP1A2,PLCB1,PRKG1,ADCY2
2.616e-03	-5.95	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	4	7161	26	ATP1A2,ADCY2,PLCB1,PRKG1
2.617e-03	-5.95	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	50	CLU
2.670e-03	-5.93	glial cell proliferation	biological process	GO:0014009	28	2	18204	50	NFIA,CLU
2.698e-03	-5.92	EN1 (engrailed homeobox 1)	protein interactions	2019	108	3	19454	50	AHCYL1,TRPS1,NFIA
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	PKcGMP_CC	interpro domains	IPR031831	1	1	18521	50	PRKG1
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.700e-03	-5.91	RBMS3_RRM2	interpro domains	IPR034406	1	1	18521	50	RBMS3
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.700e-03	-5.91	PLC-beta1_EF	interpro domains	IPR028400	1	1	18521	50	PLCB1
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	M14_CPE_CPD	interpro domains	IPR034232	1	1	18521	50	CPE
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.708e-03	-5.91	metal chelating activity	molecular function	GO:0046911	1	1	18094	49	APOE
2.708e-03	-5.91	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	49	NTRK2
2.747e-03	-5.90	cellular response to glyceraldehyde	biological process	GO:1905631	1	1	18204	50	PLCB1
2.747e-03	-5.90	response to glyceraldehyde	biological process	GO:1905630	1	1	18204	50	PLCB1
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	50	NTRK2
2.747e-03	-5.90	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	50	APOE
2.747e-03	-5.90	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	50	APOE
2.747e-03	-5.90	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	50	NRG3
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.747e-03	-5.90	positive regulation of CD24 production	biological process	GO:2000560	1	1	18204	50	PLCB1
2.747e-03	-5.90	regulation of CD24 production	biological process	GO:2000559	1	1	18204	50	PLCB1
2.747e-03	-5.90	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	50	CLU
2.747e-03	-5.90	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	50	APOE
2.747e-03	-5.90	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	50	APOE
2.747e-03	-5.90	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	50	APOE
2.747e-03	-5.90	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	50	APOE
2.747e-03	-5.90	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	50	FMN2
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	50	NTRK2
2.747e-03	-5.90	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	50	CLU
2.747e-03	-5.90	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	50	NRG3
2.747e-03	-5.90	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	50	APOE
2.747e-03	-5.90	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	50	APOE
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.754e-03	-5.89	PKcGMP_CC	pfam domains	PF16808	1	1	17795	49	PRKG1
2.784e-03	-5.88	lipoprotein particle receptor binding	molecular function	GO:0070325	29	2	18094	49	CLU,APOE
2.863e-03	-5.86	postsynaptic membrane organization	biological process	GO:0001941	29	2	18204	50	APOE,NRXN1
2.863e-03	-5.86	cGMP-mediated signaling	biological process	GO:0019934	29	2	18204	50	APOE,PRKG1
2.863e-03	-5.86	peripheral nervous system axon ensheathment	biological process	GO:0032292	29	2	18204	50	PARD3,NTRK2
2.863e-03	-5.86	myelination in peripheral nervous system	biological process	GO:0022011	29	2	18204	50	NTRK2,PARD3
2.863e-03	-5.86	DST (dystonin)	protein interactions	667	230	4	19454	50	TNIK,NTRK2,ATP1A2,PARD3
2.922e-03	-5.84	regulation of steroid metabolic process	biological process	GO:0019218	104	3	18204	50	RORA,APOE,PRKG1
2.934e-03	-5.83	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	7	18094	49	AQP4,GPM6A,SLC4A4,SLC1A2,ATP1A2,TRPM3,RYR3
2.961e-03	-5.82	cEGF	interpro domains	IPR026823	30	2	18521	50	LRP1B,EFEMP1
2.973e-03	-5.82	catenin complex	cellular component	GO:0016342	31	2	19108	50	CTNNA2,CDH20
2.978e-03	-5.82	poly-pyrimidine tract binding	molecular function	GO:0008187	30	2	18094	49	MSI2,RBMS3
2.985e-03	-5.81	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	4	16828	48	LRP1B,SLC4A4,PRKG1,ATP13A4
2.991e-03	-5.81	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	3	19454	50	TRPS1,SOX5,NFIA
3.002e-03	-5.81	neural precursor cell proliferation	biological process	GO:0061351	105	3	18204	50	SOX5,RORA,NFIA
3.060e-03	-5.79	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	26	SLC4A4,ATP1A2
3.060e-03	-5.79	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	26	ATP1A2,SLC4A4
3.062e-03	-5.79	neurotransmitter uptake	biological process	GO:0001504	30	2	18204	50	ATP1A2,SLC1A2
3.076e-03	-5.78	cEGF	pfam domains	PF12662	30	2	17795	49	LRP1B,EFEMP1
3.108e-03	-5.77	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	31	ATP1A2,SORBS1,AHCYL1,RYR3
3.168e-03	-5.75	cell body	cellular component	GO:0044297	556	6	19108	50	GPM6A,NRXN1,ATP1A2,CTNND2,SLC1A2,APOE
3.195e-03	-5.75	ion binding	molecular function	GO:0043167	6007	26	18094	49	PRKG1,ATP1A2,GLIS3,DCLK2,SPARCL1,NRXN1,PARD3,CPE,PITPNC1,SPON1,ABLIM1,RORA,DTNA,RYR3,EFEMP1,PLCB1,ATP13A4,TNIK,TRPS1,MGAT4C,SLC1A2,MAPK10,APOE,ADCY2,LRP1B,NTRK2
3.225e-03	-5.74	axonogenesis	biological process	GO:0007409	366	5	18204	50	PRKG1,PARD3,PTPRZ1,CTNNA2,NRXN1
3.249e-03	-5.73	NTM (neurotrimin)	protein interactions	50863	33	2	19454	50	LSAMP,GPM6A
3.249e-03	-5.73	VLDLR (very low density lipoprotein receptor)	protein interactions	7436	33	2	19454	50	APOE,CLU
3.249e-03	-5.73	TRPC3 (transient receptor potential cation channel subfamily C member 3)	protein interactions	7222	33	2	19454	50	PRKG1,PLCB1
3.282e-03	-5.72	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	49	ATP1A2,ATP13A4
3.336e-03	-5.70	postsynapse organization	biological process	GO:0099173	109	3	18204	50	APOE,NRXN1,CTNND2
3.357e-03	-5.70	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	4	16828	48	PLCB1,RFX4,DTNA,MGAT4C
3.375e-03	-5.69	cell migration	biological process	GO:0016477	921	8	18204	50	GPC5,NTRK2,CTNNA2,PRKG1,FMN2,CDH20,GPM6A,NRG3
3.391e-03	-5.69	Ion channel transport	REACTOME pathways	R-HSA-983712	209	4	10285	31	TRPM3,ATP1A2,RYR3,ATP13A4
3.404e-03	-5.68	cellular response to endogenous stimulus	biological process	GO:0071495	1135	9	18204	50	SOX5,ATP1A2,SORBS1,NTRK2,PLCB1,AHCYL1,NFIA,SLC1A2,RYR3
3.446e-03	-5.67	Insulin secretion	KEGG pathways	hsa04911	85	3	7161	26	ATP1A2,ADCY2,PLCB1
3.465e-03	-5.67	CEACAM8 (CEA cell adhesion molecule 8)	protein interactions	1088	118	3	19454	50	APOE,CLU,CPE
3.479e-03	-5.66	transepithelial transport	biological process	GO:0070633	32	2	18204	50	SLC1A2,AHCYL1
3.495e-03	-5.66	Cation_ATPase	pfam domains	PF13246	32	2	17795	49	ATP13A4,ATP1A2
3.519e-03	-5.65	EGF-like_dom	interpro domains	IPR000742	232	4	18521	50	NRG3,LRP1B,EFEMP1,NRXN1
3.611e-03	-5.62	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	44	CLU
3.611e-03	-5.62	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	44	CLU
3.692e-03	-5.60	dendrite development	biological process	GO:0016358	113	3	18204	50	CTNNA2,CTNND2,PRKG1
3.697e-03	-5.60	response to auditory stimulus	biological process	GO:0010996	33	2	18204	50	NRXN1,ATP1A2
3.714e-03	-5.60	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	48	PLCB1,ADCY2,MGAT4C,SLC4A4,ATP13A4,PRKG1,SORBS1,CTNND2,LRP1B
3.724e-03	-5.59	nervous system process	biological process	GO:0050877	1376	10	18204	50	AQP4,PTPRZ1,EFEMP1,CTNNA2,ABLIM1,ATP1A2,APOE,NTRK2,NRXN1,PLCB1
3.749e-03	-5.59	membrane	cellular component	GO:0016020	9220	34	19108	50	LRP1B,CPE,SLC1A2,DTNA,RYR3,CDH20,CTNNA2,ADCY2,GPC5,ATP13A4,PLCB1,MGAT4C,TRPM3,PARD3,APOE,PTPRZ1,NRG3,NTRK2,PRKG1,SLC4A4,ATP1A2,FMN2,GPM6A,MAPK10,AQP4,AHCYL1,CTNND2,LSAMP,NRXN1,TNIK,CLU,NKAIN3,SORBS1,HPSE2
3.785e-03	-5.58	regulation of circadian rhythm	biological process	GO:0042752	114	3	18204	50	MAPK10,PRKG1,RORA
3.801e-03	-5.57	Gap junction	KEGG pathways	hsa04540	88	3	7161	26	PLCB1,PRKG1,ADCY2
3.801e-03	-5.57	Gap junction	KEGG pathways	ko04540	88	3	7161	26	ADCY2,PRKG1,PLCB1
3.821e-03	-5.57	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	4	16828	48	PLCB1,DTNA,RFX4,MGAT4C
3.829e-03	-5.57	gallbladder	COSMIC cancer mutations	gallbladder	2821	16	16828	48	CLU,PRKG1,LRP1B,NRG3,TNIK,PTPRZ1,PARD3,TRPS1,FMN2,TRPM3,CTNND2,SPARCL1,NKAIN3,PITPNC1,SLC4A4,RYR3
3.829e-03	-5.57	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	16	16828	48	SPARCL1,NKAIN3,PITPNC1,SLC4A4,RYR3,TRPM3,CTNND2,PTPRZ1,PARD3,TRPS1,FMN2,CLU,PRKG1,NRG3,LRP1B,TNIK
3.866e-03	-5.56	cell adhesion molecule binding	molecular function	GO:0050839	560	6	18094	49	CTNNA2,CTNND2,PTPRZ1,NRXN1,CDH20,CPE
3.908e-03	-5.54	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	7	18094	49	SLC4A4,GPM6A,RYR3,TRPM3,ATP1A2,SLC1A2,ATP13A4
3.910e-03	-5.54	calcium channel activity	molecular function	GO:0005262	117	3	18094	49	GPM6A,RYR3,TRPM3
3.921e-03	-5.54	exploration behavior	biological process	GO:0035640	34	2	18204	50	ATP1A2,APOE
3.994e-03	-5.52	plasma lipoprotein particle	cellular component	GO:0034358	36	2	19108	50	CLU,APOE
3.994e-03	-5.52	lipoprotein particle	cellular component	GO:1990777	36	2	19108	50	APOE,CLU
4.169e-03	-5.48	synapse assembly	biological process	GO:0007416	118	3	18204	50	NRXN1,NRG3,GPM6A
4.196e-03	-5.47	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	3	16828	48	SOX5,RYR3,SLC1A2
4.215e-03	-5.47	glial cell projection	cellular component	GO:0097386	37	2	19108	50	AQP4,SLC1A2
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP13A4,ATP1A2
4.258e-03	-5.46	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	3	19454	50	ABLIM1,PARD3,DTNA
4.268e-03	-5.46	proteoglycan binding	molecular function	GO:0043394	36	2	18094	49	HPSE2,APOE
4.290e-03	-5.45	MMP3 (matrix metallopeptidase 3)	protein interactions	4314	38	2	19454	50	APOE,CLU
4.308e-03	-5.45	GnRH signaling pathway	KEGG pathways	ko04912	92	3	7161	26	MAPK10,ADCY2,PLCB1
4.308e-03	-5.45	GnRH signaling pathway	KEGG pathways	hsa04912	92	3	7161	26	PLCB1,ADCY2,MAPK10
4.370e-03	-5.43	striated muscle contraction	biological process	GO:0006941	120	3	18204	50	DTNA,ATP1A2,RYR3
4.400e-03	-5.43	AQUAPORIN4	prints domains	PR02016	1	1	5227	23	AQP4
4.400e-03	-5.43	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	23	NTRK2
4.414e-03	-5.42	Integration of energy metabolism	REACTOME pathways	R-HSA-163685	111	3	10285	31	ADCY2,PLCB1,AHCYL1
4.451e-03	-5.41	monoatomic ion transport	biological process	GO:0006811	964	8	18204	50	ATP13A4,GPM6A,SLC4A4,RYR3,PLCB1,TRPM3,SLC1A2,ATP1A2
4.472e-03	-5.41	protein kinase activity	molecular function	GO:0004672	577	6	18094	49	EFEMP1,PRKG1,NTRK2,TNIK,DCLK2,MAPK10
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP13A4,ATP1A2
4.481e-03	-5.41	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	13	16828	48	DTNA,PTPRZ1,TRPS1,ADCY2,NFIA,ATP1A2,PRKG1,LRP1B,TNIK,DCLK2,NTRK2,SLC4A4,SOX5
4.602e-03	-5.38	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	6	19454	50	PARD3,DTNA,AHCYL1,ABLIM1,CLU,TNIK
4.631e-03	-5.38	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	50	SORBS1,SLC1A2
4.639e-03	-5.37	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	47	16828	48	RORA,TRPS1,FMN2,LRP1B,NRXN1,GLIS3,SORBS1,PITPNC1,ABLIM1,NTRK2,HPSE2,SOX5,TRPM3,ADCY2,DTNA,TNIK,NRG3,NFIA,PRKG1,RYR3,SLC1A2,MGAT4C,EFEMP1,SLC4A4,GPM6A,SPARCL1,NKAIN3,DCLK2,RFX4,PARD3,PTPRZ1,AHCYL1,CLU,GPC5,CPE,LSAMP,CDH20,RBMS3,NEBL,MSI2,ATP1A2,SPON1,PLCB1,CTNND2,AQP4,NPAS3,ATP13A4
4.645e-03	-5.37	DAG and IP3 signaling	REACTOME pathways	R-HSA-1489509	34	2	10285	31	AHCYL1,ADCY2
4.674e-03	-5.37	protein-lipid complex	cellular component	GO:0032994	39	2	19108	50	CLU,APOE
4.691e-03	-5.36	monoatomic cation transport	biological process	GO:0006812	766	7	18204	50	GPM6A,SLC4A4,RYR3,ATP13A4,ATP1A2,TRPM3,PLCB1
4.740e-03	-5.35	cytoskeletal protein binding	molecular function	GO:0008092	989	8	18094	49	FMN2,CLU,CTNNA2,DCLK2,SORBS1,APOE,ABLIM1,NEBL
4.744e-03	-5.35	DZIP1 (DAZ interacting zinc finger protein 1)	protein interactions	22873	40	2	19454	50	NTRK2,PARD3
4.823e-03	-5.33	Laminin	gene3d domains	2.10.25.10	226	4	14470	44	EFEMP1,NRXN1,NRG3,LRP1B
4.880e-03	-5.32	fluid transport	biological process	GO:0042044	38	2	18204	50	AHCYL1,AQP4
4.927e-03	-5.31	response to stimulus	biological process	GO:0050896	7803	31	18204	50	RORA,AHCYL1,PITPNC1,CTNNA2,RYR3,SLC1A2,APOE,ADCY2,DCLK2,SORBS1,PARD3,RBMS3,MAPK10,NTRK2,NRXN1,PRKG1,ATP1A2,CTNND2,DTNA,TNIK,CPE,SPARCL1,NFIA,PLCB1,CLU,SOX5,EFEMP1,FMN2,NRG3,AQP4,GPM6A
4.940e-03	-5.31	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	6	18094	49	ATP1A2,SLC1A2,RYR3,TRPM3,SLC4A4,GPM6A
4.944e-03	-5.31	calcium ion transport	biological process	GO:0006816	251	4	18204	50	GPM6A,RYR3,PLCB1,TRPM3
4.969e-03	-5.30	intracellular chemical homeostasis	biological process	GO:0055082	581	6	18204	50	ATP1A2,APOE,RYR3,AQP4,SLC4A4,ATP13A4
4.980e-03	-5.30	RASSF7 (Ras association domain family member 7)	protein interactions	8045	41	2	19454	50	PARD3,CLU
4.980e-03	-5.30	ZNF646 (zinc finger protein 646)	protein interactions	9726	41	2	19454	50	EFEMP1,PRKG1
4.997e-03	-5.30	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	3	7161	26	MAPK10,ADCY2,PLCB1
4.997e-03	-5.30	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	3	7161	26	PLCB1,ADCY2,MAPK10
5.020e-03	-5.29	localization	biological process	GO:0051179	4474	21	18204	50	FMN2,SLC4A4,AQP4,GPM6A,SLC1A2,APOE,PLCB1,TRPM3,DCLK2,CLU,PARD3,LRP1B,TNIK,ATP13A4,RYR3,CPE,NTRK2,NRXN1,AHCYL1,ATP1A2,PITPNC1
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	SPARCL1,PLCB1,RYR3,DTNA
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	TRIM39-RPP21 (TRIM39-RPP21 readthrough)	protein interactions	202658	2	1	19454	50	PRKG1
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	positive regulation of nitric oxide biosynthetic process	biological process	GO:0045429	39	2	18204	50	APOE,CLU
5.134e-03	-5.27	cellular response to alkaloid	biological process	GO:0071312	39	2	18204	50	SLC1A2,RYR3
5.138e-03	-5.27	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	11	18204	50	TNIK,NTRK2,RORA,PRKG1,ATP1A2,MAPK10,PLCB1,ADCY2,PTPRZ1,EFEMP1,DCLK2
5.148e-03	-5.27	small molecule binding	molecular function	GO:0036094	6197	26	18094	49	DTNA,RYR3,ATP13A4,EFEMP1,PLCB1,TNIK,TRPS1,SLC1A2,MGAT4C,MAPK10,LRP1B,ADCY2,NTRK2,APOE,PRKG1,ATP1A2,GLIS3,DCLK2,SPARCL1,NRXN1,PARD3,CPE,SPON1,ABLIM1,PITPNC1,RORA
5.197e-03	-5.26	EGFR interacts with phospholipase C-gamma	REACTOME pathways	R-HSA-212718	36	2	10285	31	ADCY2,AHCYL1
5.197e-03	-5.26	PLC-gamma1 signalling	REACTOME pathways	R-HSA-167021	36	2	10285	31	ADCY2,AHCYL1
5.227e-03	-5.25	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	50	APOE
5.227e-03	-5.25	chylomicron remnant	cellular component	GO:0034360	2	1	19108	50	APOE
5.231e-03	-5.25	myelination	biological process	GO:0042552	128	3	18204	50	NTRK2,CLU,PARD3
5.231e-03	-5.25	glial cell development	biological process	GO:0021782	128	3	18204	50	NTRK2,PARD3,CLU
5.299e-03	-5.24	protein complex oligomerization	biological process	GO:0051259	256	4	18204	50	AQP4,RYR3,TRPM3,SLC1A2
5.328e-03	-5.23	establishment of localization	biological process	GO:0051234	3887	19	18204	50	RYR3,CPE,ATP13A4,LRP1B,ATP1A2,PITPNC1,NTRK2,NRXN1,AHCYL1,SLC4A4,AQP4,GPM6A,FMN2,CLU,PARD3,APOE,PLCB1,TRPM3,SLC1A2
5.331e-03	-5.23	EGF_3	prosite domains	PS50026	196	4	12186	44	LRP1B,NRG3,NRXN1,EFEMP1
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	44	ATP1A2,ATP13A4
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	44	ATP13A4,ATP1A2
5.366e-03	-5.23	NFIB (nuclear factor I B)	protein interactions	4781	138	3	19454	50	NFIA,TRPS1,SOX5
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	PLC-beta_CS	interpro domains	IPR009535	2	1	18521	50	PLCB1
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	STKc_cGK	interpro domains	IPR035014	2	1	18521	50	PRKG1
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	Glyco_hydro_79	interpro domains	IPR005199	2	1	18521	50	HPSE2
5.392e-03	-5.22	Spondin_N	interpro domains	IPR009465	2	1	18521	50	SPON1
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	Spondin_N_sf	interpro domains	IPR038678	2	1	18521	50	SPON1
5.392e-03	-5.22	LRP1-like_beta_prop	interpro domains	IPR032485	2	1	18521	50	LRP1B
5.392e-03	-5.22	Par3/HAL_N	interpro domains	IPR021922	2	1	18521	50	PARD3
5.392e-03	-5.22	cGMP_dep_kinase	interpro domains	IPR002374	2	1	18521	50	PRKG1
5.395e-03	-5.22	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	2	18204	50	RORA,ADCY2
5.395e-03	-5.22	positive regulation of nitric oxide metabolic process	biological process	GO:1904407	40	2	18204	50	APOE,CLU
5.409e-03	-5.22	cGMP-dependent protein kinase activity	molecular function	GO:0004692	2	1	18094	49	PRKG1
5.409e-03	-5.22	heparanase activity	molecular function	GO:0030305	2	1	18094	49	HPSE2
5.461e-03	-5.21	ensheathment of neurons	biological process	GO:0007272	130	3	18204	50	PARD3,CLU,NTRK2
5.461e-03	-5.21	axon ensheathment	biological process	GO:0008366	130	3	18204	50	PARD3,CLU,NTRK2
5.486e-03	-5.21	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	50	CLU
5.486e-03	-5.21	negative regulation of inositol phosphate biosynthetic process	biological process	GO:0010920	2	1	18204	50	PRKG1
5.486e-03	-5.21	negative regulation of monocyte extravasation	biological process	GO:2000438	2	1	18204	50	PLCB1
5.486e-03	-5.21	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	50	APOE
5.486e-03	-5.21	phosphatidylinositol catabolic process	biological process	GO:0031161	2	1	18204	50	PLCB1
5.486e-03	-5.21	cellular response to fluoride	biological process	GO:1902618	2	1	18204	50	PLCB1
5.486e-03	-5.21	activation of meiosis involved in egg activation	biological process	GO:0060466	2	1	18204	50	PLCB1
5.500e-03	-5.20	Reeler	pfam domains	PF02014	2	1	17795	49	SPON1
5.500e-03	-5.20	Glyco_hydro_79n	pfam domains	PF03662	2	1	17795	49	HPSE2
5.500e-03	-5.20	DUF1154	pfam domains	PF06631	2	1	17795	49	PLCB1
5.500e-03	-5.20	Spond_N	pfam domains	PF06468	2	1	17795	49	SPON1
5.500e-03	-5.20	DUF5050	pfam domains	PF16472	2	1	17795	49	LRP1B
5.500e-03	-5.20	Clusterin	pfam domains	PF01093	2	1	17795	49	CLU
5.500e-03	-5.20	Par3_HAL_N_term	pfam domains	PF12053	2	1	17795	49	PARD3
5.565e-03	-5.19	ASX_HYDROXYL	prosite domains	PS00010	100	3	12186	44	NRXN1,EFEMP1,LRP1B
5.595e-03	-5.19	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	3	7161	26	MAPK10,ADCY2,PLCB1
5.595e-03	-5.19	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	3	7161	26	PLCB1,ADCY2,MAPK10
5.662e-03	-5.17	cyclic nucleotide metabolic process	biological process	GO:0009187	41	2	18204	50	RORA,ADCY2
5.734e-03	-5.16	transport	biological process	GO:0006810	3615	18	18204	50	ATP13A4,LRP1B,RYR3,CPE,NRXN1,NTRK2,AHCYL1,ATP1A2,PITPNC1,FMN2,AQP4,SLC4A4,GPM6A,PLCB1,APOE,TRPM3,SLC1A2,CLU
5.766e-03	-5.16	axon development	biological process	GO:0061564	420	5	18204	50	PARD3,PRKG1,CTNNA2,PTPRZ1,NRXN1
5.766e-03	-5.16	phosphorus metabolic process	biological process	GO:0006793	1707	11	18204	50	RORA,PLCB1,NTRK2,ADCY2,DCLK2,ATP1A2,PRKG1,PTPRZ1,EFEMP1,TNIK,MAPK10
5.817e-03	-5.15	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	50	PLCB1,RYR3,ATP1A2
5.885e-03	-5.14	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	40	16828	48	CDH20,ADCY2,DTNA,RBMS3,NRG3,NEBL,TNIK,ATP1A2,PRKG1,NFIA,MSI2,EFEMP1,SLC4A4,SPON1,RYR3,SLC1A2,NKAIN3,SPARCL1,DCLK2,PLCB1,CTNND2,RFX4,NPAS3,ATP13A4,FMN2,RORA,PTPRZ1,PARD3,LRP1B,AHCYL1,NRXN1,GLIS3,ABLIM1,NTRK2,GPC5,HPSE2,LSAMP,TRPM3,CPE,SOX5
5.935e-03	-5.13	regulation of amino acid transport	biological process	GO:0051955	42	2	18204	50	ATP1A2,PRKG1
5.935e-03	-5.13	Schwann cell development	biological process	GO:0014044	42	2	18204	50	PARD3,NTRK2
5.935e-03	-5.13	triglyceride homeostasis	biological process	GO:0070328	42	2	18204	50	APOE,RORA
5.939e-03	-5.13	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	10	16828	48	PARD3,HPSE2,PLCB1,GPC5,ADCY2,RYR3,PRKG1,NRG3,LRP1B,TRPM3
5.946e-03	-5.13	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	49	GPM6A,TRPM3,RYR3
5.946e-03	-5.12	spleen	COSMIC cancer mutations	spleen	408	5	16828	48	LRP1B,ADCY2,TNIK,SORBS1,PTPRZ1
5.981e-03	-5.12	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	4	18204	50	CTNND2,RBMS3,APOE,GPC5
6.041e-03	-5.11	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	14	16828	48	TRPM3,NPAS3,SPON1,RYR3,SPARCL1,LRP1B,SORBS1,NFIA,CLU,FMN2,TRPS1,CDH20,APOE,PARD3
6.041e-03	-5.11	alveolar	COSMIC cancer mutations	alveolar	2414	14	16828	48	SPARCL1,RYR3,SPON1,NPAS3,TRPM3,PARD3,APOE,TRPS1,FMN2,CDH20,NFIA,SORBS1,CLU,LRP1B
6.044e-03	-5.11	tau protein binding	molecular function	GO:0048156	43	2	18094	49	CLU,APOE
6.073e-03	-5.10	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	44	CTNNA2
6.073e-03	-5.10	F-spondin domain	gene3d domains	2.60.40.2130	2	1	14470	44	SPON1
6.073e-03	-5.10	-	gene3d domains	6.20.350.10	2	1	14470	44	RYR3
6.190e-03	-5.08	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	4	16828	48	SLC4A4,FMN2,PTPRZ1,ATP13A4
6.190e-03	-5.08	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	7	16828	48	DCLK2,ADCY2,NTRK2,PRKG1,CTNND2,TNIK,SOX5
6.190e-03	-5.08	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	7	16828	48	NTRK2,ADCY2,DCLK2,SOX5,TNIK,CTNND2,PRKG1
6.213e-03	-5.08	acylglycerol homeostasis	biological process	GO:0055090	43	2	18204	50	RORA,APOE
6.216e-03	-5.08	actin binding	molecular function	GO:0003779	434	5	18094	49	SORBS1,CTNNA2,FMN2,NEBL,ABLIM1
6.234e-03	-5.08	EXTL2 (exostosin like glycosyltransferase 2)	protein interactions	2135	46	2	19454	50	CLU,MGAT4C
6.234e-03	-5.08	DKK2 (dickkopf WNT signaling pathway inhibitor 2)	protein interactions	27123	46	2	19454	50	LRP1B,AHCYL1
6.237e-03	-5.08	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	5	18204	50	ATP13A4,APOE,SLC4A4,RYR3,ATP1A2
6.237e-03	-5.08	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	5	18204	50	NTRK2,PLCB1,NRG3,SORBS1,EFEMP1
6.272e-03	-5.07	DSCR9 (Down syndrome critical region 9)	protein interactions	257203	146	3	19454	50	EFEMP1,CLU,SPARCL1
6.387e-03	-5.05	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	4	18094	49	SLC1A2,ATP1A2,ATP13A4,SLC4A4
6.420e-03	-5.05	trans-synaptic signaling	biological process	GO:0099537	431	5	18204	50	APOE,NTRK2,NRXN1,SLC1A2,DTNA
6.425e-03	-5.05	CEP128 (centrosomal protein 128)	protein interactions	145508	289	4	19454	50	SORBS1,NEBL,ABLIM1,AHCYL1
6.498e-03	-5.04	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	50	SORBS1,SLC1A2
6.500e-03	-5.04	BDNF (brain derived neurotrophic factor)	protein interactions	627	47	2	19454	50	CPE,NTRK2
6.500e-03	-5.04	CNTN1 (contactin 1)	protein interactions	1272	47	2	19454	50	PTPRZ1,GPM6A
6.512e-03	-5.03	LRP2 (LDL receptor related protein 2)	protein interactions	4036	148	3	19454	50	LRP1B,APOE,CLU
6.550e-03	-5.03	postsynapse	cellular component	GO:0098794	646	6	19108	50	CTNND2,ATP1A2,GPM6A,PLCB1,TNIK,NTRK2
6.634e-03	-5.02	GSE1 (Gse1 coiled-coil protein)	protein interactions	23199	149	3	19454	50	TNIK,NFIA,SOX5
6.640e-03	-5.01	bone-femur-chondrosarcoma	COSMIC cancer mutations	bone-femur-chondrosarcoma	419	5	16828	48	SLC4A4,SPON1,LRP1B,ADCY2,HPSE2
6.676e-03	-5.01	inorganic cation transmembrane transport	biological process	GO:0098662	618	6	18204	50	TRPM3,PLCB1,ATP1A2,RYR3,SLC4A4,GPM6A
6.702e-03	-5.01	neurotransmitter transport	biological process	GO:0006836	140	3	18204	50	ATP1A2,NRXN1,SLC1A2
6.702e-03	-5.01	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	46	16828	48	AHCYL1,CLU,PARD3,PTPRZ1,CPE,LSAMP,GPC5,NEBL,MSI2,ATP1A2,CDH20,APOE,CTNND2,AQP4,NPAS3,ATP13A4,SPON1,PLCB1,LRP1B,NRXN1,GLIS3,SORBS1,RORA,TRPS1,FMN2,SOX5,TRPM3,PITPNC1,ABLIM1,NTRK2,HPSE2,TNIK,NRG3,NFIA,PRKG1,ADCY2,DTNA,RYR3,MGAT4C,SLC1A2,EFEMP1,GPM6A,SLC4A4,SPARCL1,NKAIN3,DCLK2
6.702e-03	-5.01	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	46	16828	48	CDH20,APOE,NEBL,MSI2,ATP1A2,SPON1,PLCB1,AQP4,CTNND2,ATP13A4,NPAS3,PARD3,PTPRZ1,AHCYL1,CLU,GPC5,CPE,LSAMP,ADCY2,DTNA,TNIK,NRG3,NFIA,PRKG1,MGAT4C,SLC1A2,RYR3,GPM6A,SLC4A4,EFEMP1,DCLK2,NKAIN3,SPARCL1,RORA,FMN2,TRPS1,LRP1B,NRXN1,GLIS3,SORBS1,NTRK2,ABLIM1,PITPNC1,HPSE2,SOX5,TRPM3
6.744e-03	-5.00	axon	cellular component	GO:0030424	650	6	19108	50	GPM6A,CTNNA2,NTRK2,SLC1A2,DTNA,PARD3
6.772e-03	-4.99	HTRA1 (HtrA serine peptidase 1)	protein interactions	5654	48	2	19454	50	APOE,MGAT4C
6.772e-03	-4.99	PATE1 (prostate and testis expressed 1)	protein interactions	160065	48	2	19454	50	LRP1B,CPE
6.788e-03	-4.99	negative regulation of blood coagulation	biological process	GO:0030195	45	2	18204	50	APOE,PRKG1
6.788e-03	-4.99	acidic amino acid transport	biological process	GO:0015800	45	2	18204	50	SLC1A2,NTRK2
6.798e-03	-4.99	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	5	18204	50	RYR3,ATP1A2,SLC4A4,APOE,ATP13A4
6.853e-03	-4.98	cell-cell signaling	biological process	GO:0007267	822	7	18204	50	DTNA,SLC1A2,NTRK2,APOE,PLCB1,NRXN1,CPE
6.875e-03	-4.98	transmembrane transport	biological process	GO:0055085	1264	9	18204	50	PLCB1,TRPM3,SLC1A2,ATP1A2,ATP13A4,SLC4A4,AQP4,GPM6A,RYR3
6.881e-03	-4.98	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	3	19454	50	CLU,TNIK,PRKG1
6.919e-03	-4.97	membrane raft	cellular component	GO:0045121	290	4	19108	50	ATP1A2,SLC1A2,SORBS1,ADCY2
6.969e-03	-4.97	neuron migration	biological process	GO:0001764	142	3	18204	50	GPM6A,PRKG1,NTRK2
6.969e-03	-4.97	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	50	SORBS1,SLC4A4,APOE
7.044e-03	-4.96	protein binding	molecular function	GO:0005515	13983	45	18094	49	HPSE2,GLIS3,FMN2,PTPRZ1,ABLIM1,MSI2,PARD3,SOX5,NRXN1,GPM6A,PLCB1,EFEMP1,APOE,SORBS1,NFIA,NTRK2,ADCY2,NRG3,MAPK10,SLC4A4,NPAS3,DCLK2,ATP1A2,PRKG1,CLU,CTNNA2,RORA,GPC5,PITPNC1,SPON1,CPE,SPARCL1,TRPS1,TNIK,NEBL,DTNA,RYR3,AHCYL1,AQP4,CTNND2,LRP1B,RFX4,CDH20,SLC1A2,LSAMP
7.055e-03	-4.95	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	20	16828	48	LRP1B,SORBS1,CLU,NFIA,GLIS3,CDH20,TRPS1,FMN2,ADCY2,RORA,PTPRZ1,APOE,PARD3,TRPM3,CTNND2,AQP4,NPAS3,SPON1,RYR3,SPARCL1
7.084e-03	-4.95	regulation of myelination	biological process	GO:0031641	46	2	18204	50	PARD3,PTPRZ1
7.084e-03	-4.95	negative regulation of hemostasis	biological process	GO:1900047	46	2	18204	50	PRKG1,APOE
7.084e-03	-4.95	receptor clustering	biological process	GO:0043113	46	2	18204	50	APOE,NRXN1
7.086e-03	-4.95	membrane microdomain	cellular component	GO:0098857	292	4	19108	50	ADCY2,SORBS1,ATP1A2,SLC1A2
7.095e-03	-4.95	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	6	18204	50	NTRK2,PLCB1,NFIA,EFEMP1,SORBS1,NRG3
7.110e-03	-4.95	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	13	16828	48	PTPRZ1,DTNA,TRPS1,ADCY2,ATP1A2,PRKG1,NFIA,LRP1B,TNIK,DCLK2,NTRK2,SLC4A4,SOX5
7.135e-03	-4.94	SOX6 (SRY-box transcription factor 6)	protein interactions	55553	153	3	19454	50	SOX5,TRPS1,NFIA
7.203e-03	-4.93	SFN (stratifin)	protein interactions	2810	671	6	19454	50	SORBS1,FMN2,PARD3,NFIA,TNIK,ABLIM1
7.209e-03	-4.93	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	44	SPARCL1
7.209e-03	-4.93	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	44	SPARCL1
7.209e-03	-4.93	SPONDIN	prosite domains	PS51020	2	1	12186	44	SPON1
7.312e-03	-4.92	metal ion transport	biological process	GO:0030001	630	6	18204	50	SLC4A4,GPM6A,RYR3,PLCB1,TRPM3,ATP1A2
7.352e-03	-4.91	Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME pathways	R-HSA-432040	43	2	10285	31	AQP4,ADCY2
7.386e-03	-4.91	Schwann cell differentiation	biological process	GO:0014037	47	2	18204	50	NTRK2,PARD3
7.386e-03	-4.91	regulation of neuron migration	biological process	GO:2001222	47	2	18204	50	NRG3,CTNNA2
7.426e-03	-4.90	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	44	ATP1A2,ATP13A4
7.509e-03	-4.89	regulation of cellular process	biological process	GO:0050794	11468	40	18204	50	NTRK2,NRXN1,GPC5,PRKG1,ATP1A2,DTNA,CTNND2,TNIK,CPE,SPARCL1,SPON1,NFIA,PLCB1,SOX5,CLU,EFEMP1,MSI2,FMN2,NRG3,SLC4A4,GPM6A,RORA,AHCYL1,PITPNC1,CTNNA2,GLIS3,RYR3,SLC1A2,APOE,NPAS3,ADCY2,SORBS1,DCLK2,PARD3,PTPRZ1,RFX4,TRPS1,HPSE2,RBMS3,MAPK10
7.521e-03	-4.89	adult behavior	biological process	GO:0030534	146	3	18204	50	ATP1A2,NRXN1,SLC1A2
7.525e-03	-4.89	CEP19 (centrosomal protein 19)	protein interactions	84984	156	3	19454	50	ABLIM1,PARD3,FMN2
7.542e-03	-4.89	intracellular signaling cassette	biological process	GO:0141124	837	7	18204	50	TNIK,MAPK10,RYR3,ADCY2,APOE,ATP1A2,PRKG1
7.586e-03	-4.88	regulation of localization	biological process	GO:0032879	2028	12	18204	50	NKAIN3,SLC1A2,APOE,PLCB1,DCLK2,CLU,SORBS1,RYR3,AHCYL1,GPC5,ATP1A2,PRKG1
7.601e-03	-4.88	CLa	smart domains	SM00035	2	1	9717	37	CLU
7.601e-03	-4.88	CLb	smart domains	SM00030	2	1	9717	37	CLU
7.617e-03	-4.88	FAM171B (family with sequence similarity 171 member B)	protein interactions	165215	51	2	19454	50	NTRK2,PARD3
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.688e-03	-4.87	Retinoid metabolism and transport	REACTOME pathways	R-HSA-975634	44	2	10285	31	GPC5,APOE
7.691e-03	-4.87	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	50	NRXN1
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.790e-03	-4.85	calcium channel regulator activity	molecular function	GO:0005246	49	2	18094	49	NRXN1,PRKG1
7.825e-03	-4.85	Glutamatergic synapse	KEGG pathways	ko04724	114	3	7161	26	ADCY2,PLCB1,SLC1A2
7.825e-03	-4.85	Glutamatergic synapse	KEGG pathways	hsa04724	114	3	7161	26	SLC1A2,ADCY2,PLCB1
7.909e-03	-4.84	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	50	SORBS1,NTRK2
8.007e-03	-4.83	negative regulation of coagulation	biological process	GO:0050819	49	2	18204	50	PRKG1,APOE
8.065e-03	-4.82	PTPN14 (protein tyrosine phosphatase non-receptor type 14)	protein interactions	5784	160	3	19454	50	AHCYL1,PARD3,CTNNA2
8.065e-03	-4.82	SOX5 (SRY-box transcription factor 5)	protein interactions	6660	160	3	19454	50	NFIA,SOX5,TRPS1
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	Reeler_dom	interpro domains	IPR002861	3	1	18521	50	SPON1
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	MAPK_JNK	interpro domains	IPR008351	3	1	18521	50	MAPK10
8.078e-03	-4.82	Adenosylhomocyst_ase-like_sf	interpro domains	IPR042172	3	1	18521	50	AHCYL1
8.078e-03	-4.82	Ado_hCys_hydrolase_NAD-bd	interpro domains	IPR015878	3	1	18521	50	AHCYL1
8.078e-03	-4.82	S-Ado-L-homoCys_hydrolase_CS	interpro domains	IPR020082	3	1	18521	50	AHCYL1
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	PLC-beta_C	interpro domains	IPR014815	3	1	18521	50	PLCB1
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	Reeler_sf	interpro domains	IPR042307	3	1	18521	50	SPON1
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	Adenosylhomocysteinase-like	interpro domains	IPR000043	3	1	18521	50	AHCYL1
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	NRXN1,SORBS1,DTNA,PARD3
8.103e-03	-4.82	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	49	SLC1A2
8.103e-03	-4.82	adenosylhomocysteinase activity	molecular function	GO:0004013	3	1	18094	49	AHCYL1
8.103e-03	-4.82	hydrolase activity, acting on carbon-sulfur bonds	molecular function	GO:0046508	3	1	18094	49	AHCYL1
8.103e-03	-4.82	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular function	GO:0008454	3	1	18094	49	MGAT4C
8.103e-03	-4.82	JUN kinase activity	molecular function	GO:0004705	3	1	18094	49	MAPK10
8.103e-03	-4.82	epidermal growth factor receptor activity	molecular function	GO:0005006	3	1	18094	49	EFEMP1
8.131e-03	-4.81	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	10	16828	48	PTPRZ1,GPC5,DTNA,FMN2,EFEMP1,RYR3,SORBS1,NPAS3,LRP1B,NRG3
8.218e-03	-4.80	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	50	FMN2
8.218e-03	-4.80	response to ionomycin	biological process	GO:1904636	3	1	18204	50	PLCB1
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.218e-03	-4.80	immune complex clearance	biological process	GO:0002434	3	1	18204	50	CLU
8.218e-03	-4.80	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	50	NRXN1
8.218e-03	-4.80	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	50	NTRK2
8.218e-03	-4.80	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	50	APOE
8.218e-03	-4.80	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	50	CLU
8.218e-03	-4.80	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	50	NEBL
8.218e-03	-4.80	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	50	CTNNA2
8.218e-03	-4.80	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	50	FMN2
8.218e-03	-4.80	cellular response to ionomycin	biological process	GO:1904637	3	1	18204	50	PLCB1
8.218e-03	-4.80	regulation of retrograde trans-synaptic signaling by endocanabinoid	biological process	GO:0099178	3	1	18204	50	PLCB1
8.218e-03	-4.80	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	50	FMN2
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.218e-03	-4.80	mammary placode formation	biological process	GO:0060596	3	1	18204	50	NRG3
8.218e-03	-4.80	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	50	APOE
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.238e-03	-4.80	Sorb	pfam domains	PF02208	3	1	17795	49	SORBS1
8.238e-03	-4.80	AdoHcyase_NAD	pfam domains	PF00670	3	1	17795	49	AHCYL1
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR3
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR3
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK2
8.238e-03	-4.80	PLC-beta_C	pfam domains	PF08703	3	1	17795	49	PLCB1
8.238e-03	-4.80	Myelin_PLP	pfam domains	PF01275	3	1	17795	49	GPM6A
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR3
8.238e-03	-4.80	AdoHcyase	pfam domains	PF05221	3	1	17795	49	AHCYL1
8.266e-03	-4.80	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	48	2	16828	48	PARD3,RYR3
8.316e-03	-4.79	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	38	16828	48	TNIK,NRG3,NEBL,MSI2,NFIA,ATP1A2,PRKG1,ADCY2,CDH20,RBMS3,CTNND2,NPAS3,ATP13A4,RFX4,RYR3,SLC1A2,EFEMP1,SPON1,SLC4A4,SPARCL1,NKAIN3,PLCB1,LRP1B,AHCYL1,GLIS3,NRXN1,RORA,FMN2,PARD3,PTPRZ1,CPE,SOX5,LSAMP,TRPM3,ABLIM1,NTRK2,HPSE2,GPC5
8.316e-03	-4.79	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	38	16828	48	RBMS3,ADCY2,CDH20,MSI2,ATP1A2,NFIA,PRKG1,TNIK,NEBL,NRG3,SPARCL1,NKAIN3,PLCB1,RYR3,SLC1A2,EFEMP1,SPON1,SLC4A4,NPAS3,ATP13A4,RFX4,CTNND2,PARD3,PTPRZ1,RORA,FMN2,GLIS3,NRXN1,LRP1B,AHCYL1,GPC5,HPSE2,ABLIM1,NTRK2,SOX5,CPE,LSAMP,TRPM3
8.327e-03	-4.79	vasodilation	biological process	GO:0042311	50	2	18204	50	PRKG1,APOE
8.369e-03	-4.78	cell surface	cellular component	GO:0009986	896	7	19108	50	CLU,GPC5,NRXN1,SLC4A4,SLC1A2,ATP1A2,AQP4
8.397e-03	-4.78	regulation of tube diameter	biological process	GO:0035296	152	3	18204	50	PRKG1,ATP1A2,APOE
8.397e-03	-4.78	blood vessel diameter maintenance	biological process	GO:0097746	152	3	18204	50	APOE,ATP1A2,PRKG1
8.541e-03	-4.76	protein localization to membrane	biological process	GO:0072657	462	5	18204	50	TNIK,NRXN1,APOE,PARD3,CPE
8.549e-03	-4.76	regulation of tube size	biological process	GO:0035150	153	3	18204	50	ATP1A2,PRKG1,APOE
8.554e-03	-4.76	SNCA (synuclein alpha)	protein interactions	6622	696	6	19454	50	NTRK2,TNIK,CLU,GPM6A,APOE,PLCB1
8.604e-03	-4.76	cellular response to stimulus	biological process	GO:0051716	6307	26	18204	50	CTNND2,DTNA,ATP1A2,PRKG1,NTRK2,CPE,SPARCL1,TNIK,EFEMP1,CLU,PLCB1,NFIA,AQP4,NRG3,FMN2,PITPNC1,AHCYL1,RORA,RYR3,PARD3,DCLK2,SORBS1,ADCY2,APOE,SLC1A2,MAPK10
8.702e-03	-4.74	hindbrain development	biological process	GO:0030902	154	3	18204	50	RORA,PRKG1,CTNNA2
8.730e-03	-4.74	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	31	RYR3,AHCYL1,ATP1A2
8.748e-03	-4.74	ZYX (zyxin)	protein interactions	7791	316	4	19454	50	ABLIM1,AHCYL1,NEBL,SORBS1
8.764e-03	-4.74	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	20	16828	48	TRPM3,AQP4,CTNND2,NPAS3,SPON1,RYR3,SPARCL1,LRP1B,CLU,NFIA,SORBS1,GLIS3,CDH20,FMN2,TRPS1,RORA,ADCY2,PTPRZ1,APOE,PARD3
8.771e-03	-4.74	EGR2 (early growth response 2)	protein interactions	1959	165	3	19454	50	NFIA,TRPS1,SOX5
8.782e-03	-4.74	FORMIN	prints domains	PR00828	2	1	5227	23	FMN2
8.782e-03	-4.74	CGMPKINASE	prints domains	PR00104	2	1	5227	23	PRKG1
8.814e-03	-4.73	PLCB1 (phospholipase C beta 1)	protein interactions	23236	55	2	19454	50	PARD3,PLCB1
8.841e-03	-4.73	neuronal cell body	cellular component	GO:0043025	489	5	19108	50	GPM6A,NRXN1,CTNND2,ATP1A2,APOE
8.860e-03	-4.73	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	13	16828	48	ATP1A2,LRP1B,NRG3,PTPRZ1,FMN2,RFX4,TRPM3,CTNND2,SOX5,HPSE2,NTRK2,EFEMP1,SLC1A2
8.869e-03	-4.73	mannosyl-glycoprotein N-acetylglucosaminyltransferases	BIOCYC pathways	META_PWY-7426	8	1	902	1	MGAT4C
8.873e-03	-4.72	muscle system process	biological process	GO:0003012	297	4	18204	50	ATP1A2,RYR3,PRKG1,DTNA
8.903e-03	-4.72	endoplasmic reticulum lumen	cellular component	GO:0005788	312	4	19108	50	SPARCL1,APOE,CLU,SPON1
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	ATP1A2,NEBL,ABLIM1
8.928e-03	-4.72	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	6	16828	48	FMN2,PTPRZ1,PLCB1,NEBL,NFIA,SORBS1
8.972e-03	-4.71	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	3	18094	49	SLC4A4,SLC1A2,ATP1A2
8.985e-03	-4.71	positive regulation of biological process	biological process	GO:0048518	6326	26	18204	50	AHCYL1,RORA,GLIS3,APOE,NPAS3,SLC1A2,PTPRZ1,RFX4,SORBS1,PARD3,HPSE2,RBMS3,NTRK2,NRXN1,GPC5,ATP1A2,PRKG1,TNIK,SPON1,PLCB1,NFIA,SOX5,CLU,FMN2,SLC4A4,GPM6A
9.013e-03	-4.71	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	50	GPM6A,NTRK2,NFIA
9.053e-03	-4.70	CTNNB1 (catenin beta 1)	protein interactions	1499	926	7	19454	50	PARD3,DTNA,SORBS1,APOE,CTNNA2,CTNND2,PTPRZ1
9.066e-03	-4.70	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	49	ATP13A4,ATP1A2
9.095e-03	-4.70	-	gene3d domains	6.10.250.2510	3	1	14470	44	CTNNA2
9.095e-03	-4.70	Adenosylhomocysteinase-like	gene3d domains	3.40.50.1480	3	1	14470	44	AHCYL1
9.095e-03	-4.70	Reeler domain	gene3d domains	2.60.40.4060	3	1	14470	44	SPON1
9.095e-03	-4.70	-	gene3d domains	1.10.490.160	3	1	14470	44	RYR3
9.125e-03	-4.70	SEPTIN3 (septin 3)	protein interactions	55964	56	2	19454	50	GPM6A,PRKG1
9.191e-03	-4.69	EF-hand	gene3d domains	1.10.238.10	272	4	14470	44	SPARCL1,DTNA,PLCB1,RYR3
9.215e-03	-4.69	Vascular smooth muscle contraction	KEGG pathways	ko04270	121	3	7161	26	PLCB1,PRKG1,ADCY2
9.215e-03	-4.69	Vascular smooth muscle contraction	KEGG pathways	hsa04270	121	3	7161	26	ADCY2,PRKG1,PLCB1
9.303e-03	-4.68	Prot_kinase_dom	interpro domains	IPR000719	480	5	18521	50	NTRK2,MAPK10,TNIK,DCLK2,PRKG1
9.318e-03	-4.68	regulation of platelet activation	biological process	GO:0010543	53	2	18204	50	APOE,PRKG1
9.337e-03	-4.67	transmembrane transporter activity	molecular function	GO:0022857	1110	8	18094	49	GPM6A,SLC4A4,AQP4,TRPM3,RYR3,ATP1A2,SLC1A2,ATP13A4
9.442e-03	-4.66	NXPH3 (neurexophilin 3)	protein interactions	11248	57	2	19454	50	CTNNA2,NRXN1
9.442e-03	-4.66	NOS3 (nitric oxide synthase 3)	protein interactions	4846	57	2	19454	50	EFEMP1,APOE
9.475e-03	-4.66	Ser/Thr_kinase_AS	interpro domains	IPR008271	308	4	18521	50	PRKG1,DCLK2,TNIK,MAPK10
9.637e-03	-4.64	Platelet activation	KEGG pathways	hsa04611	123	3	7161	26	ADCY2,PRKG1,PLCB1
9.659e-03	-4.64	regulation of alcohol biosynthetic process	biological process	GO:1902930	54	2	18204	50	APOE,PRKG1
9.665e-03	-4.64	TLX1 (T cell leukemia homeobox 1)	protein interactions	3195	171	3	19454	50	NFIA,AHCYL1,TRPS1
9.669e-03	-4.64	presynaptic membrane	cellular component	GO:0042734	168	3	19108	50	GPM6A,NRXN1,SLC1A2
9.714e-03	-4.63	cell motility	biological process	GO:0048870	1101	8	18204	50	NTRK2,GPC5,PRKG1,CTNNA2,CDH20,FMN2,NRG3,GPM6A
9.819e-03	-4.62	negative regulation of supramolecular fiber organization	biological process	GO:1902904	161	3	18204	50	CTNNA2,CLU,APOE
9.833e-03	-4.62	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	4	19454	50	SORBS1,TNIK,DTNA,PARD3
9.954e-03	-4.61	calcium ion binding	molecular function	GO:0005509	683	6	18094	49	EFEMP1,PLCB1,LRP1B,NRXN1,RYR3,SPARCL1
1.001e-02	-4.60	intermembrane lipid transfer	biological process	GO:0120009	55	2	18204	50	PITPNC1,APOE
1.002e-02	-4.60	Znf_NHR/GATA	interpro domains	IPR013088	56	2	18521	50	RORA,TRPS1
1.008e-02	-4.60	lipid transfer activity	molecular function	GO:0120013	56	2	18094	49	APOE,PITPNC1
1.009e-02	-4.60	VEGFA (vascular endothelial growth factor A)	protein interactions	7422	59	2	19454	50	PTPRZ1,CLU
1.009e-02	-4.60	ANKRD36B (ankyrin repeat domain 36B)	protein interactions	57730	59	2	19454	50	LRP1B,AHCYL1
1.009e-02	-4.60	CATATPASE	prints domains	PR00119	35	2	5227	23	ATP1A2,ATP13A4
1.016e-02	-4.59	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	6	18094	49	EFEMP1,PRKG1,DCLK2,NTRK2,TNIK,MAPK10
1.017e-02	-4.59	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	298	4	16828	48	CTNND2,FMN2,LRP1B,ATP1A2
1.024e-02	-4.58	IGKV@ (immunoglobulin kappa variable cluster)	protein interactions	3519	4	1	19454	50	LRP1B
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.029e-02	-4.58	LRP1 (LDL receptor related protein 1)	protein interactions	4035	175	3	19454	50	APOE,LRP1B,CLU
1.029e-02	-4.58	LHX3 (LIM homeobox 3)	protein interactions	8022	175	3	19454	50	NFIA,TRPS1,SOX5
1.031e-02	-4.58	dendritic spine	cellular component	GO:0043197	172	3	19108	50	ATP1A2,GPM6A,NTRK2
1.032e-02	-4.57	negative regulation of neuron apoptotic process	biological process	GO:0043524	164	3	18204	50	NTRK2,PTPRZ1,CLU
1.036e-02	-4.57	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	50	RYR3,PLCB1
1.040e-02	-4.57	export from cell	biological process	GO:0140352	485	5	18204	50	NTRK2,NRXN1,CPE,ATP1A2,SLC4A4
1.041e-02	-4.57	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	48	RYR3,TRPS1,PRKG1,GPC5
1.042e-02	-4.56	BTN2A1 (butyrophilin subfamily 2 member A1)	protein interactions	11120	60	2	19454	50	PLCB1,FMN2
1.043e-02	-4.56	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	50	APOE
1.043e-02	-4.56	internode region of axon	cellular component	GO:0033269	4	1	19108	50	PARD3
1.058e-02	-4.55	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	10	16828	48	PRKG1,LRP1B,NRG3,TRPM3,PLCB1,GPC5,HPSE2,PARD3,ADCY2,RYR3
1.062e-02	-4.55	Aquaporin-mediated transport	REACTOME pathways	R-HSA-445717	52	2	10285	31	ADCY2,AQP4
1.063e-02	-4.54	neuron spine	cellular component	GO:0044309	174	3	19108	50	ATP1A2,GPM6A,NTRK2
1.072e-02	-4.54	visual behavior	biological process	GO:0007632	57	2	18204	50	SLC1A2,ATP1A2
1.072e-02	-4.54	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	50	RYR3,PLCB1
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	PLC-beta	interpro domains	IPR016280	4	1	18521	50	PLCB1
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	PLC-beta_PH	interpro domains	IPR037862	4	1	18521	50	PLCB1
1.076e-02	-4.53	PLC-beta_C_sf	interpro domains	IPR042531	4	1	18521	50	PLCB1
1.076e-02	-4.53	Glyco_transf_54	interpro domains	IPR006759	4	1	18521	50	MGAT4C
1.076e-02	-4.53	ApoA_E	interpro domains	IPR000074	4	1	18521	50	APOE
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	PRKG1,TNIK
1.079e-02	-4.53	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	49	NTRK2
1.079e-02	-4.53	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	49	RYR3
1.079e-02	-4.53	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	49	APOE
1.079e-02	-4.53	ADOHCYASE_1	prosite domains	PS00738	3	1	12186	44	AHCYL1
1.079e-02	-4.53	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	44	GPM6A
1.079e-02	-4.53	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	44	GPM6A
1.079e-02	-4.53	SOHO	prosite domains	PS50831	3	1	12186	44	SORBS1
1.079e-02	-4.53	REELIN	prosite domains	PS51019	3	1	12186	44	SPON1
1.079e-02	-4.53	VINCULIN_1	prosite domains	PS00663	3	1	12186	44	CTNNA2
1.079e-02	-4.53	ADOHCYASE_2	prosite domains	PS00739	3	1	12186	44	AHCYL1
1.080e-02	-4.53	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	50	DTNA,CTNNA2,CDH20
1.084e-02	-4.52	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	47	16828	48	TNIK,NRG3,PRKG1,NFIA,ADCY2,DTNA,RFX4,MGAT4C,SLC1A2,RYR3,GPM6A,SLC4A4,EFEMP1,DCLK2,SPARCL1,NKAIN3,LRP1B,GLIS3,NRXN1,SORBS1,RORA,TRPS1,FMN2,SOX5,TRPM3,NTRK2,ABLIM1,PITPNC1,HPSE2,NEBL,MSI2,ATP1A2,CDH20,APOE,CTNND2,AQP4,ATP13A4,NPAS3,SPON1,PLCB1,AHCYL1,CLU,PARD3,PTPRZ1,CPE,LSAMP,GPC5
1.085e-02	-4.52	adrenal_cortical_adenoma	COSMIC cancer mutations	adrenal_cortical_adenoma	161	3	16828	48	ADCY2,LRP1B,FMN2
1.086e-02	-4.52	extracellular region	cellular component	GO:0005576	4350	19	19108	50	GPC5,LSAMP,CPE,AQP4,SPON1,AHCYL1,EFEMP1,SLC4A4,ATP1A2,GPM6A,HPSE2,PLCB1,NEBL,SPARCL1,APOE,TNIK,PTPRZ1,NRG3,CLU
1.094e-02	-4.52	protein localization to secretory granule	biological process	GO:0033366	4	1	18204	50	CPE
1.094e-02	-4.52	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	50	APOE
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.094e-02	-4.52	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	50	CLU
1.094e-02	-4.52	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	50	APOE
1.094e-02	-4.52	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	50	APOE
1.094e-02	-4.52	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	50	NTRK2
1.094e-02	-4.52	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	50	NTRK2
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.094e-02	-4.52	response to fluoride	biological process	GO:1902617	4	1	18204	50	PLCB1
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	response to caloric restriction	biological process	GO:0061771	4	1	18204	50	APOE
1.097e-02	-4.51	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	49	NFIA
1.097e-02	-4.51	AbLIM_anchor	pfam domains	PF16182	4	1	17795	49	ABLIM1
1.097e-02	-4.51	TRPM_tetra	pfam domains	PF16519	4	1	17795	49	TRPM3
1.097e-02	-4.51	Apolipoprotein	pfam domains	PF01442	4	1	17795	49	APOE
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	PH_14	pfam domains	PF17787	4	1	17795	49	PLCB1
1.097e-02	-4.51	P5-ATPase	pfam domains	PF12409	4	1	17795	49	ATP13A4
1.097e-02	-4.51	CTF_NFI	pfam domains	PF00859	4	1	17795	49	NFIA
1.097e-02	-4.51	Nebulin	pfam domains	PF00880	4	1	17795	49	NEBL
1.097e-02	-4.51	Glyco_transf_54	pfam domains	PF04666	4	1	17795	49	MGAT4C
1.097e-02	-4.51	HSPA5 (heat shock protein family A (Hsp70) member 5)	protein interactions	3309	1455	9	19454	50	PARD3,HPSE2,DTNA,LRP1B,APOE,EFEMP1,AHCYL1,CLU,GPC5
1.101e-02	-4.51	Metabolism of fat-soluble vitamins	REACTOME pathways	R-HSA-6806667	53	2	10285	31	GPC5,APOE
1.106e-02	-4.50	biological regulation	biological process	GO:0065007	12501	42	18204	50	SLC1A2,ADCY2,NPAS3,APOE,PARD3,SORBS1,DCLK2,RFX4,PTPRZ1,HPSE2,TRPS1,RBMS3,MAPK10,RORA,AHCYL1,PITPNC1,CTNNA2,GLIS3,RYR3,NFIA,PLCB1,SOX5,CLU,EFEMP1,FMN2,MSI2,NRG3,NKAIN3,GPM6A,SLC4A4,AQP4,GPC5,NTRK2,NRXN1,PRKG1,ATP1A2,DTNA,CTNND2,TNIK,SPON1,SPARCL1,CPE
1.110e-02	-4.50	cellular homeostasis	biological process	GO:0019725	689	6	18204	50	ATP1A2,APOE,RYR3,AQP4,SLC4A4,ATP13A4
1.110e-02	-4.50	EPHA4 (EPH receptor A4)	protein interactions	2043	180	3	19454	50	AHCYL1,PARD3,CTNNA2
1.110e-02	-4.50	MYOD1 (myogenic differentiation 1)	protein interactions	4654	180	3	19454	50	NFIA,RORA,TRPS1
1.114e-02	-4.50	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	6	16828	48	SPARCL1,DCLK2,NTRK2,PRKG1,LRP1B,TNIK
1.117e-02	-4.49	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	48	PRKG1,GPC5,RYR3,TRPS1,GPM6A
1.122e-02	-4.49	regulation of biological process	biological process	GO:0050789	12079	41	18204	50	FMN2,MSI2,NRG3,NKAIN3,GPM6A,SLC4A4,NFIA,PLCB1,CLU,SOX5,EFEMP1,TNIK,CPE,SPON1,SPARCL1,GPC5,NTRK2,NRXN1,PRKG1,ATP1A2,DTNA,CTNND2,HPSE2,TRPS1,RBMS3,MAPK10,SLC1A2,ADCY2,NPAS3,APOE,PARD3,SORBS1,DCLK2,RFX4,PTPRZ1,GLIS3,RYR3,RORA,AHCYL1,PITPNC1,CTNNA2
1.132e-02	-4.48	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	41	16828	48	SPON1,GPM6A,SLC4A4,RYR3,SLC1A2,MGAT4C,SPARCL1,DCLK2,PLCB1,CTNND2,RFX4,NPAS3,ATP13A4,CDH20,ADCY2,DTNA,NRG3,NEBL,TNIK,ATP1A2,PRKG1,NFIA,PITPNC1,ABLIM1,NTRK2,GPC5,HPSE2,LSAMP,TRPM3,SOX5,CPE,TRPS1,FMN2,RORA,PTPRZ1,PARD3,LRP1B,AHCYL1,SORBS1,GLIS3,NRXN1
1.133e-02	-4.48	actin cytoskeleton	cellular component	GO:0015629	520	5	19108	50	ABLIM1,FMN2,NEBL,SORBS1,CTNNA2
1.138e-02	-4.48	Sorb	smart domains	SM00459	3	1	9717	37	SORBS1
1.138e-02	-4.48	PLP	smart domains	SM00002	3	1	9717	37	GPM6A
1.138e-02	-4.48	AdoHcyase	smart domains	SM00996	3	1	9717	37	AHCYL1
1.138e-02	-4.48	AdoHcyase_NAD	smart domains	SM00997	3	1	9717	37	AHCYL1
1.141e-02	-4.47	Heparan sulfate/heparin (HS-GAG) metabolism	REACTOME pathways	R-HSA-1638091	54	2	10285	31	GPC5,HPSE2
1.142e-02	-4.47	cervix	COSMIC cancer mutations	cervix	11793	41	16828	48	NFIA,ATP1A2,PRKG1,NRG3,NEBL,TNIK,DTNA,CDH20,ADCY2,RFX4,ATP13A4,NPAS3,CTNND2,PLCB1,DCLK2,SPARCL1,GPM6A,SPON1,SLC4A4,SLC1A2,MGAT4C,RYR3,SORBS1,NRXN1,GLIS3,AHCYL1,LRP1B,PTPRZ1,PARD3,FMN2,TRPS1,RORA,TRPM3,LSAMP,SOX5,CPE,GPC5,HPSE2,NTRK2,PITPNC1,ABLIM1
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.144e-02	-4.47	NLGN2 (neuroligin 2)	protein interactions	57555	63	2	19454	50	CLU,NRXN1
1.145e-02	-4.47	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	6	16828	48	PRKG1,TNIK,LRP1B,DCLK2,SPARCL1,NTRK2
1.165e-02	-4.45	metal ion binding	molecular function	GO:0046872	4239	19	18094	49	SPARCL1,NRXN1,MGAT4C,SLC1A2,CPE,SPON1,ABLIM1,APOE,RORA,LRP1B,ADCY2,RYR3,DTNA,PLCB1,EFEMP1,ATP13A4,ATP1A2,GLIS3,TRPS1
1.171e-02	-4.45	organic substance transport	biological process	GO:0071702	1881	11	18204	50	CPE,SLC4A4,LRP1B,FMN2,ATP13A4,PITPNC1,CLU,SLC1A2,AHCYL1,NTRK2,APOE
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	NFIA,TRPS1
1.182e-02	-4.44	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	50	NTRK2,ATP1A2
1.182e-02	-4.44	regulation of smooth muscle contraction	biological process	GO:0006940	60	2	18204	50	ATP1A2,PRKG1
1.182e-02	-4.44	export across plasma membrane	biological process	GO:0140115	60	2	18204	50	SLC4A4,ATP1A2
1.182e-02	-4.44	protein homotetramerization	biological process	GO:0051289	60	2	18204	50	AQP4,RYR3
1.182e-02	-4.44	regulation of glucose import	biological process	GO:0046324	60	2	18204	50	SORBS1,SLC1A2
1.187e-02	-4.43	lower_third	COSMIC cancer mutations	lower_third	7961	31	16828	48	CPE,SOX5,TRPM3,GPC5,HPSE2,NTRK2,NRXN1,SORBS1,LRP1B,PARD3,PTPRZ1,RORA,FMN2,TRPS1,NPAS3,ATP13A4,CTNND2,AQP4,PLCB1,DCLK2,RYR3,MGAT4C,EFEMP1,SLC4A4,SPON1,ATP1A2,PRKG1,NEBL,NRG3,ADCY2,CDH20
1.192e-02	-4.43	chemical homeostasis	biological process	GO:0048878	914	7	18204	50	ATP13A4,RYR3,SLC4A4,AQP4,RORA,APOE,ATP1A2
1.200e-02	-4.42	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	1	10285	31	SLC1A2
1.200e-02	-4.42	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	1	10285	31	SLC1A2
1.204e-02	-4.42	protein phosphorylation	biological process	GO:0006468	503	5	18204	50	TNIK,NTRK2,PRKG1,MAPK10,EFEMP1
1.204e-02	-4.42	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	5	16828	48	LSAMP,LRP1B,SLC4A4,RYR3,ATP13A4
1.204e-02	-4.42	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	5	16828	48	LSAMP,LRP1B,SLC4A4,RYR3,ATP13A4
1.205e-02	-4.42	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	48	16828	48	NPAS3,ATP13A4,CTNND2,AQP4,PLCB1,SPON1,MSI2,ATP1A2,NEBL,RBMS3,APOE,CDH20,CPE,LSAMP,GPC5,CLU,AHCYL1,PARD3,PTPRZ1,RFX4,SPARCL1,NKAIN3,DCLK2,RYR3,SLC1A2,MGAT4C,EFEMP1,GPM6A,SLC4A4,NFIA,PRKG1,TNIK,NRG3,DTNA,ADCY2,SOX5,TRPM3,HPSE2,ABLIM1,PITPNC1,NTRK2,NRXN1,GLIS3,SORBS1,LRP1B,RORA,TRPS1,FMN2
1.211e-02	-4.41	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	44	TRPM3
1.211e-02	-4.41	Phospholipase C beta, distal C-terminal domain	gene3d domains	1.20.1230.10	4	1	14470	44	PLCB1
1.211e-02	-4.41	-	gene3d domains	2.30.29.240	4	1	14470	44	PLCB1
1.223e-02	-4.40	monoatomic cation homeostasis	biological process	GO:0055080	505	5	18204	50	ATP13A4,APOE,ATP1A2,RYR3,SLC4A4
1.223e-02	-4.40	cellular response to organonitrogen compound	biological process	GO:0071417	505	5	18204	50	SORBS1,RYR3,SLC1A2,AHCYL1,PLCB1
1.225e-02	-4.40	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	49	EFEMP1,NTRK2
1.230e-02	-4.40	KLF5 (KLF transcription factor 5)	protein interactions	688	187	3	19454	50	TRPS1,CLU,NFIA
1.230e-02	-4.40	regulation of lipid metabolic process	biological process	GO:0019216	327	4	18204	50	RORA,APOE,SORBS1,PRKG1
1.234e-02	-4.39	salivary_gland-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma-adenoid_cystic_carcinoma	488	5	16828	48	MGAT4C,RORA,RYR3,CTNND2,PRKG1
1.240e-02	-4.39	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	hsa04961	47	2	7161	26	ATP1A2,PLCB1
1.240e-02	-4.39	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	ko04961	47	2	7161	26	ATP1A2,PLCB1
1.248e-02	-4.38	HNF1B (HNF1 homeobox B)	protein interactions	6928	188	3	19454	50	NFIA,SOX5,TRPS1
1.249e-02	-4.38	central nervous system neuron differentiation	biological process	GO:0021953	176	3	18204	50	DCLK2,NTRK2,RORA
1.250e-02	-4.38	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	2	19454	50	CLU,APOE
1.252e-02	-4.38	circulatory system process	biological process	GO:0003013	508	5	18204	50	PRKG1,ATP1A2,SLC4A4,SLC1A2,APOE
1.254e-02	-4.38	Erythroid Transcription Factor GATA-1, subunit A	gene3d domains	3.30.50.10	56	2	14470	44	TRPS1,RORA
1.261e-02	-4.37	CDH1 (cadherin 1)	protein interactions	999	757	6	19454	50	ABLIM1,PARD3,CTNNA2,NEBL,SORBS1,CTNND2
1.262e-02	-4.37	CTBP2 (C-terminal binding protein 2)	protein interactions	1488	352	4	19454	50	MAPK10,TRPS1,PLCB1,MSI2
1.266e-02	-4.37	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	14	16828	48	SLC1A2,NTRK2,EFEMP1,HPSE2,CTNND2,SOX5,TRPM3,RFX4,ADCY2,FMN2,PTPRZ1,LRP1B,NRG3,ATP1A2
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.279e-02	-4.36	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	50	NRXN1
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	PPP1R17 (protein phosphatase 1 regulatory subunit 17)	protein interactions	10842	5	1	19454	50	PRKG1
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	TRH (thyrotropin releasing hormone)	protein interactions	7200	5	1	19454	50	CPE
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.287e-02	-4.35	ZNF696 (zinc finger protein 696)	protein interactions	79943	67	2	19454	50	AHCYL1,EFEMP1
1.287e-02	-4.35	PARD6A (par-6 family cell polarity regulator alpha)	protein interactions	50855	67	2	19454	50	PARD3,PLCB1
1.291e-02	-4.35	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	44	16828	48	NRG3,TNIK,PRKG1,NFIA,ADCY2,DTNA,RFX4,GPM6A,SLC4A4,EFEMP1,SLC1A2,MGAT4C,RYR3,DCLK2,NKAIN3,LRP1B,SORBS1,GLIS3,NRXN1,TRPS1,FMN2,RORA,TRPM3,SOX5,NTRK2,PITPNC1,ABLIM1,HPSE2,NEBL,ATP1A2,MSI2,CDH20,APOE,RBMS3,CTNND2,ATP13A4,NPAS3,SPON1,PLCB1,CLU,PTPRZ1,PARD3,LSAMP,GPC5
1.298e-02	-4.34	regulation of nitric oxide biosynthetic process	biological process	GO:0045428	63	2	18204	50	APOE,CLU
1.302e-02	-4.34	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	50	CLU
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	NEBL,SORBS1
1.308e-02	-4.34	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	4	16828	48	LRP1B,FMN2,CTNND2,ATP1A2
1.309e-02	-4.34	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	31	ATP1A2,ATP13A4
1.310e-02	-4.34	temporoparietal	COSMIC cancer mutations	temporoparietal	61	2	16828	48	RYR3,PARD3
1.313e-02	-4.33	response to endogenous stimulus	biological process	GO:0009719	1402	9	18204	50	RYR3,SLC1A2,NFIA,AHCYL1,NTRK2,PLCB1,ATP1A2,SOX5,SORBS1
1.313e-02	-4.33	Kinase-like_dom_sf	interpro domains	IPR011009	523	5	18521	50	PRKG1,DCLK2,TNIK,NTRK2,MAPK10
1.314e-02	-4.33	inorganic ion transmembrane transport	biological process	GO:0098660	715	6	18204	50	ATP1A2,PLCB1,TRPM3,GPM6A,SLC4A4,RYR3
1.315e-02	-4.33	MYELINPLP	prints domains	PR00214	3	1	5227	23	GPM6A
1.315e-02	-4.33	RORNUCRECPTR	prints domains	PR01293	3	1	5227	23	RORA
1.315e-02	-4.33	RYANODINER	prints domains	PR00795	3	1	5227	23	RYR3
1.315e-02	-4.33	NTKRECEPTOR	prints domains	PR01939	3	1	5227	23	NTRK2
1.315e-02	-4.33	JNKMAPKINASE	prints domains	PR01772	3	1	5227	23	MAPK10
1.317e-02	-4.33	Apelin signaling pathway	KEGG pathways	hsa04371	138	3	7161	26	PLCB1,ADCY2,RYR3
1.322e-02	-4.33	monoatomic ion homeostasis	biological process	GO:0050801	515	5	18204	50	SLC4A4,ATP1A2,RYR3,ATP13A4,APOE
1.323e-02	-4.33	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	4	19454	50	SORBS1,NEBL,TNIK,PARD3
1.324e-02	-4.32	PLCH1 (phospholipase C eta 1)	protein interactions	23007	68	2	19454	50	PARD3,NTRK2
1.328e-02	-4.32	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	9	19454	50	APOE,ADCY2,PLCB1,MGAT4C,SLC1A2,NTRK2,MAPK10,CTNNA2,EFEMP1
1.331e-02	-4.32	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	8	16828	48	NTRK2,MGAT4C,RORA,RYR3,LRP1B,TNIK,CTNND2,PRKG1
1.332e-02	-4.32	human chr4q21.3	chromosome location	human chr4q21.3	7	1	26134	50	MAPK10
1.335e-02	-4.32	camera-type eye development	biological process	GO:0043010	335	4	18204	50	EFEMP1,GPM6A,NTRK2,NFIA
1.336e-02	-4.32	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	4	16828	48	SORBS1,PTPRZ1,ADCY2,LRP1B
1.337e-02	-4.31	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	50	SORBS1,FMN2
1.337e-02	-4.31	dendrite morphogenesis	biological process	GO:0048813	64	2	18204	50	CTNNA2,CTNND2
1.341e-02	-4.31	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	26	16828	48	ADCY2,CDH20,NEBL,NRG3,PLCB1,RYR3,MGAT4C,EFEMP1,SPON1,NPAS3,ATP13A4,CTNND2,AQP4,PARD3,PTPRZ1,RORA,TRPS1,FMN2,NRXN1,SORBS1,LRP1B,GPC5,NTRK2,SOX5,CPE,TRPM3
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.347e-02	-4.31	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	1	18094	49	SLC1A2
1.347e-02	-4.31	neuroligin family protein binding	molecular function	GO:0097109	5	1	18094	49	NRXN1
1.347e-02	-4.31	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	49	NTRK2
1.347e-02	-4.31	glutamate:sodium symporter activity	molecular function	GO:0015501	5	1	18094	49	SLC1A2
1.366e-02	-4.29	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	50	NRXN1
1.366e-02	-4.29	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	50	APOE
1.366e-02	-4.29	D-aspartate transmembrane transport	biological process	GO:0070777	5	1	18204	50	SLC1A2
1.366e-02	-4.29	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	50	FMN2
1.366e-02	-4.29	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	50	APOE
1.366e-02	-4.29	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	50	NTRK2
1.366e-02	-4.29	D-aspartate import across plasma membrane	biological process	GO:0070779	5	1	18204	50	SLC1A2
1.366e-02	-4.29	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	50	CLU
1.366e-02	-4.29	negative regulation of glutamate secretion	biological process	GO:0014050	5	1	18204	50	PRKG1
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	50	APOE
1.366e-02	-4.29	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	50	APOE
1.366e-02	-4.29	activation of meiosis	biological process	GO:0090427	5	1	18204	50	PLCB1
1.369e-02	-4.29	FOLN	pfam domains	PF09289	5	1	17795	49	SPARCL1
1.369e-02	-4.29	Vinculin	pfam domains	PF01044	5	1	17795	49	CTNNA2
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.369e-02	-4.29	main axon	cellular component	GO:0044304	68	2	19108	50	PARD3,SLC1A2
1.377e-02	-4.29	regulation of protein processing	biological process	GO:0070613	65	2	18204	50	RFX4,SPON1
1.377e-02	-4.29	positive regulation of synapse assembly	biological process	GO:0051965	65	2	18204	50	NTRK2,NRXN1
1.377e-02	-4.29	regulation of nitric oxide metabolic process	biological process	GO:0080164	65	2	18204	50	CLU,APOE
1.388e-02	-4.28	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	17	16828	48	NPAS3,CTNND2,TRPM3,PLCB1,GPC5,DCLK2,HPSE2,RYR3,SLC4A4,SPON1,ATP1A2,PRKG1,LRP1B,PARD3,PTPRZ1,ADCY2,FMN2
1.389e-02	-4.28	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	50	RBMS3,CTNND2,GPC5,APOE
1.393e-02	-4.27	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	19	16828	48	NRG3,NEBL,LRP1B,AHCYL1,ATP1A2,FMN2,TRPS1,CDH20,RORA,PARD3,CTNND2,RFX4,ATP13A4,ABLIM1,SLC4A4,MGAT4C,SLC1A2,PLCB1,GPC5
1.399e-02	-4.27	PCDH20 (protocadherin 20)	protein interactions	64881	70	2	19454	50	CTNNA2,MGAT4C
1.407e-02	-4.26	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	5	19454	50	FMN2,DTNA,PLCB1,PARD3,AHCYL1
1.418e-02	-4.26	ERBB signaling pathway	biological process	GO:0038127	66	2	18204	50	NRG3,EFEMP1
1.418e-02	-4.26	cardiac muscle cell development	biological process	GO:0055013	66	2	18204	50	PRKG1,NEBL
1.424e-02	-4.25	EGF	pfam domains	PF00008	66	2	17795	49	NRXN1,LRP1B
1.425e-02	-4.25	DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5)	protein interactions	80331	365	4	19454	50	CLU,PARD3,DTNA,AHCYL1
1.427e-02	-4.25	kinase activity	molecular function	GO:0016301	739	6	18094	49	EFEMP1,PRKG1,DCLK2,NTRK2,TNIK,MAPK10
1.433e-02	-4.25	NFIX (nuclear factor I X)	protein interactions	4784	198	3	19454	50	NFIA,TRPS1,SOX5
1.435e-02	-4.24	phosphorylation	biological process	GO:0016310	729	6	18204	50	NTRK2,TNIK,MAPK10,EFEMP1,PRKG1,DCLK2
1.435e-02	-4.24	skin-ankle-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-ankle-malignant_melanoma-acral_lentiginous	330	4	16828	48	NRG3,PARD3,ATP13A4,PLCB1
1.435e-02	-4.24	vesicle	cellular component	GO:0031982	4141	18	19108	50	NTRK2,PRKG1,TNIK,CLU,APOE,PLCB1,NEBL,GPM6A,FMN2,SLC4A4,ATP1A2,AHCYL1,EFEMP1,AQP4,CPE,SLC1A2,ATP13A4,NRXN1
1.437e-02	-4.24	NEBULIN	prosite domains	PS51216	4	1	12186	44	NEBL
1.437e-02	-4.24	CTF_NFI_1	prosite domains	PS00349	4	1	12186	44	NFIA
1.437e-02	-4.24	CTF_NFI_2	prosite domains	PS51080	4	1	12186	44	NFIA
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	TNIK,GPM6A
1.440e-02	-4.24	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	8	16828	48	TNIK,CTNND2,LRP1B,PRKG1,MGAT4C,RORA,RYR3,NTRK2
1.441e-02	-4.24	Ca2+ pathway	REACTOME pathways	R-HSA-4086398	61	2	10285	31	PLCB1,PRKG1
1.449e-02	-4.23	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	10	16828	48	PLCB1,PTPRZ1,DTNA,RORA,CDH20,ABLIM1,FMN2,SORBS1,CPE,CTNND2
1.449e-02	-4.23	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	10	16828	48	RORA,ABLIM1,FMN2,CDH20,DTNA,PTPRZ1,PLCB1,CTNND2,CPE,SORBS1
1.450e-02	-4.23	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	4	16828	48	LRP1B,ADCY2,PTPRZ1,SORBS1
1.455e-02	-4.23	Activation of PKC Through G Protein-Coupled Receptor	SMPDB pathways	SMP0000749	4	1	1369	5	PLCB1
1.459e-02	-4.23	cholesterol transport	biological process	GO:0030301	67	2	18204	50	CLU,APOE
1.476e-02	-4.22	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	50	PARD3,ABLIM1
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	GPM6A,TNIK
1.476e-02	-4.22	Adrenergic signaling in cardiomyocytes	KEGG pathways	hsa04261	144	3	7161	26	PLCB1,ADCY2,ATP1A2
1.476e-02	-4.22	Adrenergic signaling in cardiomyocytes	KEGG pathways	ko04261	144	3	7161	26	ATP1A2,PLCB1,ADCY2
1.482e-02	-4.21	Alzheimers Disease	WikiPathways	WP2059	148	3	5310	19	APOE,PLCB1,RYR3
1.498e-02	-4.20	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	31	NTRK2
1.500e-02	-4.20	cation binding	molecular function	GO:0043169	4341	19	18094	49	TRPS1,GLIS3,PLCB1,EFEMP1,ATP1A2,ATP13A4,RYR3,DTNA,APOE,LRP1B,ADCY2,RORA,ABLIM1,SPON1,MGAT4C,SLC1A2,CPE,NRXN1,SPARCL1
1.501e-02	-4.20	actin filament bundle organization	biological process	GO:0061572	68	2	18204	50	FMN2,SORBS1
1.505e-02	-4.20	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	7	16828	48	PLCB1,MGAT4C,ADCY2,SORBS1,ATP13A4,LRP1B,CTNND2
1.510e-02	-4.19	regulation of lipid biosynthetic process	biological process	GO:0046890	189	3	18204	50	APOE,SORBS1,PRKG1
1.511e-02	-4.19	Pkinase	pfam domains	PF00069	347	4	17795	49	TNIK,MAPK10,DCLK2,PRKG1
1.511e-02	-4.19	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	44	APOE
1.512e-02	-4.19	FEV (FEV transcription factor, ETS family member)	protein interactions	54738	202	3	19454	50	TRPS1,SOX5,NFIA
1.515e-02	-4.19	NEBU	smart domains	SM00227	4	1	9717	37	NEBL
1.526e-02	-4.18	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	46	16828	48	AHCYL1,CLU,PARD3,PTPRZ1,CPE,LSAMP,GPC5,NEBL,ATP1A2,CDH20,APOE,CTNND2,AQP4,ATP13A4,NPAS3,SPON1,PLCB1,LRP1B,NRXN1,GLIS3,SORBS1,RORA,FMN2,TRPS1,SOX5,TRPM3,NTRK2,ABLIM1,PITPNC1,HPSE2,TNIK,NRG3,PRKG1,NFIA,ADCY2,DTNA,RFX4,SLC1A2,MGAT4C,RYR3,SLC4A4,GPM6A,EFEMP1,DCLK2,NKAIN3,SPARCL1
1.526e-02	-4.18	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	10	18204	50	NRXN1,APOE,PLCB1,NTRK2,RORA,PTPRZ1,PARD3,CLU,ATP1A2,SOX5
1.531e-02	-4.18	pallium development	biological process	GO:0021543	190	3	18204	50	PLCB1,NTRK2,DCLK2
1.532e-02	-4.18	Rara (retinoic acid receptor, alpha)	protein interactions	19401	6	1	19454	50	MAPK10
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	50	NRXN1
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	50	APOE
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	50	APOE
1.538e-02	-4.17	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	10	16828	48	PTPRZ1,DCLK2,GPC5,PARD3,LRP1B,NEBL,TRPM3,SOX5,PRKG1,NPAS3
1.543e-02	-4.17	regulation of blood coagulation	biological process	GO:0030193	69	2	18204	50	APOE,PRKG1
1.543e-02	-4.17	regulation of protein maturation	biological process	GO:1903317	69	2	18204	50	SPON1,RFX4
1.550e-02	-4.17	EGF_CA	pfam domains	PF07645	69	2	17795	49	EFEMP1,LRP1B
1.550e-02	-4.17	LIM	pfam domains	PF00412	69	2	17795	49	NEBL,ABLIM1
1.551e-02	-4.17	pancreas-carcinoma-adenocarcinoma	COSMIC cancer mutations	pancreas-carcinoma-adenocarcinoma	517	5	16828	48	NEBL,LRP1B,DCLK2,HPSE2,GPC5
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	NRXN1,DTNA,ABLIM1
1.552e-02	-4.17	NFIC (nuclear factor I C)	protein interactions	4782	204	3	19454	50	NFIA,SOX5,TRPS1
1.554e-02	-4.16	RNF6 (ring finger protein 6)	protein interactions	6049	74	2	19454	50	AHCYL1,ABLIM1
1.560e-02	-4.16	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	50	APOE
1.560e-02	-4.16	PAR polarity complex	cellular component	GO:0120157	6	1	19108	50	PARD3
1.571e-02	-4.15	Isoprenaline Action Pathway	SMPDB pathways	SMP0000663	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Amiodarone Action Pathway	SMPDB pathways	SMP0000665	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Alprenolol Action Pathway	SMPDB pathways	SMP0000297	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Practolol Action Pathway	SMPDB pathways	SMP0000669	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Metoprolol Action Pathway	SMPDB pathways	SMP0000302	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Levobunolol Action Pathway	SMPDB pathways	SMP0000666	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Bevantolol Action Pathway	SMPDB pathways	SMP0000668	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Ibutilide Action Pathway	SMPDB pathways	SMP0000332	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Epinephrine Action Pathway	SMPDB pathways	SMP0000661	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Muscle/Heart Contraction	SMPDB pathways	SMP0000588	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Sotalol Action Pathway	SMPDB pathways	SMP0000660	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Bupranolol Action Pathway	SMPDB pathways	SMP0000670	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Timolol Action Pathway	SMPDB pathways	SMP0000659	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Arbutamine Action Pathway	SMPDB pathways	SMP0000664	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Carteolol Action Pathway	SMPDB pathways	SMP0000658	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Quinidine Action Pathway	SMPDB pathways	SMP0000323	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Disopyramide Action Pathway	SMPDB pathways	SMP0000325	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Bopindolol Action Pathway	SMPDB pathways	SMP0000657	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Mexiletine Action Pathway	SMPDB pathways	SMP0000329	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Fosphenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000326	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Nitrendipine Action Pathway	SMPDB pathways	SMP0000382	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Betaxolol Action Pathway	SMPDB pathways	SMP0000299	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Metipranolol Action Pathway	SMPDB pathways	SMP0000667	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Procainamide (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000324	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Atenolol Action Pathway	SMPDB pathways	SMP0000298	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Acebutolol Action Pathway	SMPDB pathways	SMP0000296	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Verapamil Action Pathway	SMPDB pathways	SMP0000375	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Flecainide Action Pathway	SMPDB pathways	SMP0000331	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Esmolol Action Pathway	SMPDB pathways	SMP0000301	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Tocainide Action Pathway	SMPDB pathways	SMP0000330	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Bisoprolol Action Pathway	SMPDB pathways	SMP0000300	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Nebivolol Action Pathway	SMPDB pathways	SMP0000366	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Amlodipine Action Pathway	SMPDB pathways	SMP0000376	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Isradipine Action Pathway	SMPDB pathways	SMP0000378	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Nifedipine Action Pathway	SMPDB pathways	SMP0000379	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Oxprenolol Action Pathway	SMPDB pathways	SMP0000304	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Penbutolol Action Pathway	SMPDB pathways	SMP0000305	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Nadolol Action Pathway	SMPDB pathways	SMP0000303	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Diltiazem Action Pathway	SMPDB pathways	SMP0000359	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Dobutamine Action Pathway	SMPDB pathways	SMP0000662	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Pindolol Action Pathway	SMPDB pathways	SMP0000306	57	2	1369	5	PLCB1,ATP1A2
1.571e-02	-4.15	Propranolol Action Pathway	SMPDB pathways	SMP0000307	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Nisoldipine Action Pathway	SMPDB pathways	SMP0000381	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Felodipine Action Pathway	SMPDB pathways	SMP0000377	57	2	1369	5	ATP1A2,PLCB1
1.571e-02	-4.15	Nimodipine Action Pathway	SMPDB pathways	SMP0000380	57	2	1369	5	ATP1A2,PLCB1
1.573e-02	-4.15	caecum	COSMIC cancer mutations	caecum	14248	46	16828	48	SORBS1,NRXN1,GLIS3,LRP1B,FMN2,TRPS1,RORA,TRPM3,SOX5,HPSE2,NTRK2,PITPNC1,ABLIM1,NFIA,PRKG1,NRG3,TNIK,DTNA,ADCY2,RFX4,DCLK2,NKAIN3,SPARCL1,SLC4A4,GPM6A,EFEMP1,SLC1A2,MGAT4C,RYR3,CLU,AHCYL1,PTPRZ1,PARD3,LSAMP,CPE,GPC5,ATP1A2,NEBL,APOE,CDH20,ATP13A4,NPAS3,CTNND2,AQP4,PLCB1,SPON1
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	NEBL,ABLIM1
1.585e-02	-4.14	negative regulation of smooth muscle cell proliferation	biological process	GO:0048662	70	2	18204	50	PRKG1,APOE
1.598e-02	-4.14	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	5	14470	44	TNIK,PRKG1,NTRK2,DCLK2,MAPK10
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY2
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	TSP1_spondin_dom	interpro domains	IPR044004	6	1	18521	50	SPON1
1.609e-02	-4.13	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	1	18521	50	NRXN1
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.614e-02	-4.13	steroid hormone binding	molecular function	GO:1990239	6	1	18094	49	ATP1A2
1.614e-02	-4.13	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	49	APOE
1.614e-02	-4.13	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	49	SLC4A4
1.614e-02	-4.13	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	49	RYR3
1.616e-02	-4.13	Regulation of lipolysis in adipocytes	KEGG pathways	hsa04923	54	2	7161	26	ADCY2,PRKG1
1.618e-02	-4.12	protein homooligomerization	biological process	GO:0051260	194	3	18204	50	SLC1A2,AQP4,RYR3
1.619e-02	-4.12	presynapse	cellular component	GO:0098793	569	5	19108	50	NRXN1,NTRK2,GPM6A,TNIK,SLC1A2
1.625e-02	-4.12	Labetalol Action Pathway	SMPDB pathways	SMP0000368	58	2	1369	5	ATP1A2,PLCB1
1.625e-02	-4.12	Carvedilol Action Pathway	SMPDB pathways	SMP0000367	58	2	1369	5	PLCB1,ATP1A2
1.628e-02	-4.12	regulation of hemostasis	biological process	GO:1900046	71	2	18204	50	PRKG1,APOE
1.633e-02	-4.11	BCL2L1 (BCL2 like 1)	protein interactions	598	208	3	19454	50	ABLIM1,CLU,RYR3
1.637e-02	-4.11	inositol trisphosphate metabolic process	biological process	GO:0032957	6	1	18204	50	PLCB1
1.637e-02	-4.11	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	50	APOE
1.637e-02	-4.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	1	18204	50	SLC1A2
1.637e-02	-4.11	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	50	FMN2
1.637e-02	-4.11	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	1	18204	50	NRXN1
1.637e-02	-4.11	relaxation of vascular associated smooth muscle	biological process	GO:0060087	6	1	18204	50	PRKG1
1.637e-02	-4.11	mammary gland formation	biological process	GO:0060592	6	1	18204	50	NRG3
1.637e-02	-4.11	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	50	APOE
1.637e-02	-4.11	cellular response to ether	biological process	GO:0071362	6	1	18204	50	PLCB1
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	D-amino acid transport	biological process	GO:0042940	6	1	18204	50	SLC1A2
1.637e-02	-4.11	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	50	CLU
1.637e-02	-4.11	intracellular water homeostasis	biological process	GO:0009992	6	1	18204	50	AQP4
1.637e-02	-4.11	imitative learning	biological process	GO:0098596	6	1	18204	50	NRXN1
1.637e-02	-4.11	vocal learning	biological process	GO:0042297	6	1	18204	50	NRXN1
1.637e-02	-4.11	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	50	NRG3
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	RYR3
1.641e-02	-4.11	Syndecan	pfam domains	PF01034	6	1	17795	49	NRXN1
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	RYR3
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY2
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	RYR3
1.641e-02	-4.11	EF-hand_3	pfam domains	PF09069	6	1	17795	49	DTNA
1.641e-02	-4.11	TSP1_spondin	pfam domains	PF19028	6	1	17795	49	SPON1
1.641e-02	-4.11	EF-hand_2	pfam domains	PF09068	6	1	17795	49	DTNA
1.646e-02	-4.11	protein serine kinase activity	molecular function	GO:0106310	362	4	18094	49	DCLK2,TNIK,PRKG1,MAPK10
1.664e-02	-4.10	cell-cell adhesion	biological process	GO:0098609	546	5	18204	50	CDH20,NRXN1,SPARCL1,CTNND2,CTNNA2
1.676e-02	-4.09	ADGRL2 (adhesion G protein-coupled receptor L2)	protein interactions	23266	77	2	19454	50	PARD3,NTRK2
1.676e-02	-4.09	Htt (huntingtin)	protein interactions	15194	77	2	19454	50	GPM6A,LSAMP
1.676e-02	-4.09	TAFA3 (TAFA chemokine like family member 3)	protein interactions	284467	77	2	19454	50	LRP1B,AHCYL1
1.676e-02	-4.09	actin cytoskeleton organization	biological process	GO:0030036	547	5	18204	50	PRKG1,SORBS1,FMN2,NEBL,TNIK
1.679e-02	-4.09	Lidocaine (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000328	59	2	1369	5	ATP1A2,PLCB1
1.700e-02	-4.07	localization within membrane	biological process	GO:0051668	549	5	18204	50	CPE,PARD3,TNIK,APOE,NRXN1
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP1A2,ATP13A4
1.705e-02	-4.07	Oxytocin signaling pathway	KEGG pathways	hsa04921	152	3	7161	26	ADCY2,PLCB1,RYR3
1.705e-02	-4.07	Oxytocin signaling pathway	KEGG pathways	ko04921	152	3	7161	26	PLCB1,ADCY2,RYR3
1.716e-02	-4.07	peptide metabolic process	biological process	GO:0006518	73	2	18204	50	SLC1A2,CPE
1.716e-02	-4.07	negative regulation of wound healing	biological process	GO:0061045	73	2	18204	50	APOE,PRKG1
1.716e-02	-4.07	cardiac cell development	biological process	GO:0055006	73	2	18204	50	PRKG1,NEBL
1.717e-02	-4.06	IFIT3 (interferon induced protein with tetratricopeptide repeats 3)	protein interactions	3437	78	2	19454	50	APOE,ATP1A2
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	SOX5,MSI2
1.717e-02	-4.06	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	50	CLU,APOE
1.748e-02	-4.05	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	48	SLC1A2,FMN2,PARD3,GPC5,LRP1B,TRPM3,ATP13A4
1.748e-02	-4.05	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	48	FMN2,SLC1A2,GPC5,PARD3,TRPM3,LRP1B,ATP13A4
1.749e-02	-4.05	ALPHACATENIN	prints domains	PR00805	4	1	5227	23	CTNNA2
1.759e-02	-4.04	PRDM1 (PR/SET domain 1)	protein interactions	639	79	2	19454	50	TRPS1,NFIA
1.759e-02	-4.04	STMN2 (stathmin 2)	protein interactions	11075	79	2	19454	50	MAPK10,AHCYL1
1.761e-02	-4.04	sterol transport	biological process	GO:0015918	74	2	18204	50	APOE,CLU
1.761e-02	-4.04	regulation of coagulation	biological process	GO:0050818	74	2	18204	50	APOE,PRKG1
1.762e-02	-4.04	TRAF2 (TNF receptor associated factor 2)	protein interactions	7186	592	5	19454	50	NEBL,TNIK,SOX5,EFEMP1,ABLIM1
1.765e-02	-4.04	animal organ morphogenesis	biological process	GO:0009887	988	7	18204	50	CTNNA2,EFEMP1,SOX5,ABLIM1,NTRK2,NRG3,CPE
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	TPM3P4 (tropomyosin 3 pseudogene 4)	protein interactions	402643	7	1	19454	50	AHCYL1
1.794e-02	-4.02	cortisol_producing	COSMIC cancer mutations	cortisol_producing	72	2	16828	48	FMN2,LRP1B
1.794e-02	-4.02	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	72	2	16828	48	LRP1B,FMN2
1.795e-02	-4.02	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	31	NTRK2
1.800e-02	-4.02	intracellular calcium ion homeostasis	biological process	GO:0006874	202	3	18204	50	RYR3,APOE,ATP13A4
1.801e-02	-4.02	MAP2 (microtubule associated protein 2)	protein interactions	4133	80	2	19454	50	GPM6A,APOE
1.811e-02	-4.01	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	44	RYR3
1.811e-02	-4.01	Single helix bin	gene3d domains	1.20.5.490	6	1	14470	44	PRKG1
1.815e-02	-4.01	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	5	ADCY2
1.826e-02	-4.00	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	3	19454	50	ABLIM1,RORA,NKAIN3
1.843e-02	-3.99	SOX17 (SRY-box transcription factor 17)	protein interactions	64321	81	2	19454	50	TRPS1,NFIA
1.858e-02	-3.99	nipple	COSMIC cancer mutations	nipple	197	3	16828	48	EFEMP1,FMN2,LRP1B
1.858e-02	-3.99	skin-nipple-malignant_melanoma	COSMIC cancer mutations	skin-nipple-malignant_melanoma	197	3	16828	48	LRP1B,FMN2,EFEMP1
1.860e-02	-3.98	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	6	16828	48	CDH20,PARD3,PLCB1,NRG3,LRP1B,ATP13A4
1.865e-02	-3.98	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	4	18521	50	NTRK2,TNIK,DCLK2,PRKG1
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Aquaporin_transptr	interpro domains	IPR034294	7	1	18521	50	AQP4
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.875e-02	-3.98	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Hud_Sxl_RNA	interpro domains	IPR002343	7	1	18521	50	RBMS3
1.875e-02	-3.98	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.881e-02	-3.97	mitogen-activated protein kinase p38 binding	molecular function	GO:0048273	7	1	18094	49	PRKG1
1.881e-02	-3.97	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	49	PITPNC1
1.881e-02	-3.97	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	49	ATP1A2
1.881e-02	-3.97	LBD domain binding	molecular function	GO:0050693	7	1	18094	49	SPON1
1.881e-02	-3.97	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	49	ATP1A2
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP1A2,ATP13A4
1.886e-02	-3.97	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	19	RORA,NTRK2,AQP4
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.898e-02	-3.96	cellular response to interleukin-1	biological process	GO:0071347	77	2	18204	50	RORA,PLCB1
1.898e-02	-3.96	regulation of organic acid transport	biological process	GO:0032890	77	2	18204	50	PRKG1,ATP1A2
1.898e-02	-3.96	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	2	18204	50	NRXN1,ATP1A2
1.898e-02	-3.96	neural retina development	biological process	GO:0003407	77	2	18204	50	GPM6A,NTRK2
1.905e-02	-3.96	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	5	16828	48	PRKG1,DCLK2,TNIK,FMN2,NTRK2
1.907e-02	-3.96	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	50	FMN2
1.907e-02	-3.96	regulation of monocyte extravasation	biological process	GO:2000437	7	1	18204	50	PLCB1
1.907e-02	-3.96	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	50	NRG3
1.907e-02	-3.96	S-adenosylmethionine cycle	biological process	GO:0033353	7	1	18204	50	AHCYL1
1.907e-02	-3.96	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	50	PTPRZ1
1.907e-02	-3.96	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	50	CLU
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	50	APOE
1.907e-02	-3.96	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	50	CTNNA2
1.907e-02	-3.96	mitochondrion-endoplasmic reticulum membrane tethering	biological process	GO:1990456	7	1	18204	50	AHCYL1
1.907e-02	-3.96	post-embryonic eye morphogenesis	biological process	GO:0048050	7	1	18204	50	EFEMP1
1.907e-02	-3.96	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	50	APOE
1.907e-02	-3.96	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	50	APOE
1.907e-02	-3.96	glial cell fate specification	biological process	GO:0021780	7	1	18204	50	NFIA
1.907e-02	-3.96	relaxation of smooth muscle	biological process	GO:0044557	7	1	18204	50	PRKG1
1.907e-02	-3.96	observational learning	biological process	GO:0098597	7	1	18204	50	NRXN1
1.907e-02	-3.96	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	50	FMN2
1.907e-02	-3.96	regulation of testosterone biosynthetic process	biological process	GO:2000224	7	1	18204	50	PRKG1
1.910e-02	-3.96	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	9	16828	48	NRXN1,RFX4,CTNND2,LRP1B,NEBL,PTPRZ1,RYR3,CDH20,FMN2
1.910e-02	-3.96	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	9	16828	48	PTPRZ1,RYR3,CDH20,FMN2,NRXN1,RFX4,CTNND2,NEBL,LRP1B
1.912e-02	-3.96	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	49	SPARCL1
1.912e-02	-3.96	SDF	pfam domains	PF00375	7	1	17795	49	SLC1A2
1.919e-02	-3.95	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	5	16828	48	TNIK,FMN2,NTRK2,PRKG1,DCLK2
1.925e-02	-3.95	RHOB (ras homolog family member B)	protein interactions	388	832	6	19454	50	DTNA,PLCB1,PARD3,ABLIM1,TNIK,FMN2
1.930e-02	-3.95	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	50	NFIA,TRPS1
1.930e-02	-3.95	SYT1 (synaptotagmin 1)	protein interactions	6857	83	2	19454	50	NRXN1,GPM6A
1.939e-02	-3.94	PSEN1 (presenilin 1)	protein interactions	5663	222	3	19454	50	DTNA,APOE,CTNND2
1.944e-02	-3.94	actin filament binding	molecular function	GO:0051015	211	3	18094	49	ABLIM1,NEBL,CTNNA2
1.944e-02	-3.94	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	2	18204	50	SLC4A4,SORBS1
1.944e-02	-3.94	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	50	SLC1A2,SORBS1
1.944e-02	-3.94	dicarboxylic acid transport	biological process	GO:0006835	78	2	18204	50	SLC1A2,NTRK2
1.960e-02	-3.93	skin-leg-malignant_melanoma	COSMIC cancer mutations	skin-leg-malignant_melanoma	549	5	16828	48	PLCB1,PTPRZ1,NRG3,LRP1B,NEBL
1.972e-02	-3.93	Long-term depression	KEGG pathways	ko04730	60	2	7161	26	PLCB1,PRKG1
1.972e-02	-3.93	Long-term depression	KEGG pathways	hsa04730	60	2	7161	26	PRKG1,PLCB1
1.980e-02	-3.92	regulation of system process	biological process	GO:0044057	571	5	18204	50	PRKG1,ATP1A2,PARD3,NRXN1,APOE
1.985e-02	-3.92	solute:sodium symporter activity	molecular function	GO:0015370	80	2	18094	49	SLC1A2,SLC4A4
1.989e-02	-3.92	Neuronal System	REACTOME pathways	R-HSA-112316	349	4	10285	31	NRXN1,SLC1A2,PLCB1,ADCY2
1.996e-02	-3.91	caveola	cellular component	GO:0005901	83	2	19108	50	SORBS1,ATP1A2
2.008e-02	-3.91	KLF3 (KLF transcription factor 3)	protein interactions	51274	225	3	19454	50	SOX5,TRPS1,NFIA
2.018e-02	-3.90	CFAP298 (cilia and flagella associated protein 298)	protein interactions	56683	85	2	19454	50	TRPS1,FMN2
2.020e-02	-3.90	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	8	19454	50	NFIA,CLU,AHCYL1,LSAMP,MSI2,GLIS3,SOX5,TRPS1
2.022e-02	-3.90	nitrogen compound transport	biological process	GO:0071705	1507	9	18204	50	CPE,LRP1B,ATP13A4,FMN2,CLU,SLC1A2,NTRK2,APOE,AHCYL1
2.032e-02	-3.90	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	49	NTRK2,EFEMP1
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	CCK (cholecystokinin)	protein interactions	885	8	1	19454	50	CPE
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.042e-02	-3.89	eye development	biological process	GO:0001654	381	4	18204	50	GPM6A,EFEMP1,NFIA,NTRK2
2.042e-02	-3.89	negative regulation of cell migration	biological process	GO:0030336	381	4	18204	50	PLCB1,APOE,PRKG1,NRG3
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	GPM6A,SORBS1
2.063e-02	-3.88	FAM171A1 (family with sequence similarity 171 member A1)	protein interactions	221061	86	2	19454	50	NTRK2,PARD3
2.067e-02	-3.88	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	6	16828	48	PRKG1,LRP1B,TNIK,DCLK2,NTRK2,CDH20
2.067e-02	-3.88	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	6	16828	48	DCLK2,NTRK2,CDH20,PRKG1,LRP1B,TNIK
2.072e-02	-3.88	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	44	NEBL,ABLIM1
2.075e-02	-3.88	zonula adherens	cellular component	GO:0005915	8	1	19108	50	SORBS1
2.075e-02	-3.88	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	50	CLU
2.078e-02	-3.87	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	22	16828	48	LSAMP,CTNND2,SOX5,NPAS3,ATP13A4,PITPNC1,ABLIM1,NTRK2,SPARCL1,DCLK2,PLCB1,LRP1B,AHCYL1,TNIK,CLU,PRKG1,MSI2,TRPS1,ADCY2,RORA,PTPRZ1,PARD3
2.078e-02	-3.87	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	22	16828	48	PITPNC1,ABLIM1,NTRK2,LSAMP,SOX5,TRPS1,RORA,PTPRZ1,PARD3,LRP1B,AHCYL1,CLU,SPARCL1,DCLK2,PLCB1,CTNND2,NPAS3,ATP13A4,ADCY2,TNIK,PRKG1,MSI2
2.103e-02	-3.86	cellular response to nitrogen compound	biological process	GO:1901699	580	5	18204	50	SLC1A2,AHCYL1,PLCB1,SORBS1,RYR3
2.108e-02	-3.86	ZNF608 (zinc finger protein 608)	protein interactions	57507	87	2	19454	50	NFIA,SOX5
2.108e-02	-3.86	NHLH1 (nescient helix-loop-helix 1)	protein interactions	4807	87	2	19454	50	TRPS1,NFIA
2.110e-02	-3.86	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	1	14470	44	SLC1A2
2.113e-02	-3.86	visual system development	biological process	GO:0150063	385	4	18204	50	NTRK2,NFIA,EFEMP1,GPM6A
2.117e-02	-3.86	Alzheimer's disease	KEGG pathways	hsa05010	165	3	7161	26	RYR3,PLCB1,APOE
2.117e-02	-3.86	Alzheimer's disease	KEGG pathways	ko05010	165	3	7161	26	PLCB1,APOE,RYR3
2.125e-02	-3.85	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	44	ATP13A4,ATP1A2
2.126e-02	-3.85	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	8	16828	48	ADCY2,PLCB1,GPC5,LRP1B,TRPM3,CTNND2,ATP1A2,ATP13A4
2.135e-02	-3.85	regulation of steroid biosynthetic process	biological process	GO:0050810	82	2	18204	50	APOE,PRKG1
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY2
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY2
2.140e-02	-3.84	positive regulation of cellular process	biological process	GO:0048522	5719	23	18204	50	NRXN1,NTRK2,GPC5,RORA,GLIS3,TNIK,SPON1,PLCB1,NPAS3,APOE,NFIA,SLC1A2,PTPRZ1,RFX4,CLU,SOX5,SORBS1,PARD3,FMN2,HPSE2,SLC4A4,GPM6A,RBMS3
2.146e-02	-3.84	cyclic nucleotide-dependent protein kinase activity	molecular function	GO:0004690	8	1	18094	49	PRKG1
2.146e-02	-3.84	sodium ion binding	molecular function	GO:0031402	8	1	18094	49	ATP1A2
2.146e-02	-3.84	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	49	ATP1A2
2.147e-02	-3.84	GLYPICAN	prosite domains	PS01207	6	1	12186	44	GPC5
2.153e-02	-3.84	TIMP3 (TIMP metallopeptidase inhibitor 3)	protein interactions	7078	88	2	19454	50	EFEMP1,LRP1B
2.153e-02	-3.84	NLGN3 (neuroligin 3)	protein interactions	54413	88	2	19454	50	EFEMP1,NRXN1
2.175e-02	-3.83	phosphatidylinositol-4,5-bisphosphate binding	molecular function	GO:0005546	84	2	18094	49	PARD3,PLCB1
2.175e-02	-3.83	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	5	ADCY2
2.175e-02	-3.83	Phospholipase C Signaling Pathway	SMPDB pathways	SMP0063783	6	1	1369	5	PLCB1
2.175e-02	-3.83	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	5	ADCY2
2.177e-02	-3.83	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	50	APOE
2.177e-02	-3.83	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	50	RORA
2.177e-02	-3.83	ion channel modulating, G protein-coupled receptor signaling pathway	biological process	GO:0099105	8	1	18204	50	PLCB1
2.177e-02	-3.83	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	50	RORA
2.177e-02	-3.83	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	50	APOE
2.177e-02	-3.83	response to vasopressin	biological process	GO:1904116	8	1	18204	50	PLCB1
2.177e-02	-3.83	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	50	RORA
2.177e-02	-3.83	insulin processing	biological process	GO:0030070	8	1	18204	50	CPE
2.177e-02	-3.83	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	50	NRG3
2.177e-02	-3.83	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	50	APOE
2.177e-02	-3.83	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	50	FMN2
2.177e-02	-3.83	cellular response to vasopressin	biological process	GO:1904117	8	1	18204	50	PLCB1
2.177e-02	-3.83	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	biological process	GO:0007207	8	1	18204	50	PLCB1
2.177e-02	-3.83	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	50	APOE
2.177e-02	-3.83	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	50	CTNNA2
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.182e-02	-3.83	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	23	SLC4A4
2.182e-02	-3.83	PITRANSFER	prints domains	PR00391	5	1	5227	23	PITPNC1
2.182e-02	-3.82	LSDAT_euk	pfam domains	PF18139	8	1	17795	49	TRPM3
2.182e-02	-3.82	DCX	pfam domains	PF03607	8	1	17795	49	DCLK2
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY2
2.182e-02	-3.82	VHP	pfam domains	PF02209	8	1	17795	49	ABLIM1
2.184e-02	-3.82	regulation of amine transport	biological process	GO:0051952	83	2	18204	50	ATP1A2,PRKG1
2.199e-02	-3.82	PLEKHA2 (pleckstrin homology domain containing A2)	protein interactions	59339	89	2	19454	50	AHCYL1,DTNA
2.199e-02	-3.82	SOX10 (SRY-box transcription factor 10)	protein interactions	6663	89	2	19454	50	NFIA,TRPS1
2.202e-02	-3.82	neck	COSMIC cancer mutations	neck	1231	8	16828	48	ATP13A4,ATP1A2,CTNND2,TRPM3,LRP1B,PLCB1,GPC5,ADCY2
2.215e-02	-3.81	Endothelins	Pathway Interaction DB	endothelinpathway	53	2	2226	10	PLCB1,ADCY2
2.221e-02	-3.81	sensory system development	biological process	GO:0048880	391	4	18204	50	NTRK2,NFIA,EFEMP1,GPM6A
2.224e-02	-3.81	HMG20A (high mobility group 20A)	protein interactions	10363	234	3	19454	50	SOX5,DTNA,NFIA
2.233e-02	-3.80	peripheral nervous system development	biological process	GO:0007422	84	2	18204	50	NTRK2,PARD3
2.246e-02	-3.80	CDKN2C (cyclin dependent kinase inhibitor 2C)	protein interactions	1031	90	2	19454	50	AHCYL1,MAPK10
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	FMN2,DTNA
2.249e-02	-3.79	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	3	19454	50	PARD3,DTNA,NTRK2
2.272e-02	-3.78	human chr3p24.1	chromosome location	human chr3p24.1	12	1	26134	50	RBMS3
2.272e-02	-3.78	human chr11p15.2	chromosome location	human chr11p15.2	12	1	26134	50	SPON1
2.290e-02	-3.78	BIN2 (bridging integrator 2)	protein interactions	51411	9	1	19454	50	EFEMP1
2.290e-02	-3.78	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	1	19454	50	LSAMP
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	ZNF778 (zinc finger protein 778)	protein interactions	197320	9	1	19454	50	EFEMP1
2.290e-02	-3.78	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	50	APOE
2.290e-02	-3.78	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	1	19454	50	LSAMP
2.290e-02	-3.78	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	50	APOE
2.292e-02	-3.78	PTPN21 (protein tyrosine phosphatase non-receptor type 21)	protein interactions	11099	91	2	19454	50	NRG3,AHCYL1
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	TNIK,SORBS1
2.292e-02	-3.78	FOXI1 (forkhead box I1)	protein interactions	2299	91	2	19454	50	NFIA,TRPS1
2.299e-02	-3.77	CLU (clusterin)	protein interactions	1191	237	3	19454	50	LRP1B,CLU,TNIK
2.315e-02	-3.77	negative regulation of cell motility	biological process	GO:2000146	396	4	18204	50	NRG3,PRKG1,APOE,PLCB1
2.322e-02	-3.76	single-stranded RNA binding	molecular function	GO:0003727	87	2	18094	49	RBMS3,MSI2
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	SPARCL1,CLU,LRP1B
2.331e-02	-3.76	flotillin complex	cellular component	GO:0016600	9	1	19108	50	SORBS1
2.331e-02	-3.76	astrocyte end-foot	cellular component	GO:0097450	9	1	19108	50	AQP4
2.334e-02	-3.76	central nervous system neuron development	biological process	GO:0021954	86	2	18204	50	NTRK2,DCLK2
2.339e-02	-3.76	SOX9 (SRY-box transcription factor 9)	protein interactions	6662	92	2	19454	50	TRPS1,NFIA
2.339e-02	-3.76	RLN1 (relaxin 1)	protein interactions	6013	92	2	19454	50	LRP1B,CPE
2.346e-02	-3.75	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	7	18204	50	SORBS1,SLC1A2,RORA,ADCY2,AHCYL1,PLCB1,RYR3
2.346e-02	-3.75	response to oxygen-containing compound	biological process	GO:1901700	1546	9	18204	50	APOE,PLCB1,ADCY2,AHCYL1,RORA,SLC1A2,ATP1A2,SORBS1,RYR3
2.352e-02	-3.75	organic anion transport	biological process	GO:0015711	398	4	18204	50	APOE,NTRK2,SLC1A2,SLC4A4
2.387e-02	-3.74	Free fatty acids regulate insulin secretion	REACTOME pathways	R-HSA-400451	8	1	10285	31	PLCB1
2.387e-02	-3.74	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	31	GPC5
2.387e-02	-3.74	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME pathways	R-HSA-434316	8	1	10285	31	PLCB1
2.401e-02	-3.73	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	50	PARD3,CTNND2,NTRK2
2.401e-02	-3.73	Regulation of insulin secretion	REACTOME pathways	R-HSA-422356	80	2	10285	31	AHCYL1,PLCB1
2.401e-02	-3.73	Human Thyroid Stimulating Hormone (TSH) signaling pathway	WikiPathways	WP2032	68	2	5310	19	ADCY2,PLCB1
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	Doublecortin_dom	interpro domains	IPR003533	9	1	18521	50	DCLK2
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.407e-02	-3.73	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	44	ABLIM1
2.420e-02	-3.72	ACTG1 (actin gamma 1)	protein interactions	71	429	4	19454	50	APOE,TNIK,FMN2,ABLIM1
2.422e-02	-3.72	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	49	APOE,CLU
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CLU,CTNND2
2.435e-02	-3.72	QSER1 (glutamine and serine rich 1)	protein interactions	79832	94	2	19454	50	SOX5,NFIA
2.435e-02	-3.72	AKAP17A (A-kinase anchoring protein 17A)	protein interactions	8227	94	2	19454	50	TRPM3,AHCYL1
2.435e-02	-3.72	FOXP4 (forkhead box P4)	protein interactions	116113	94	2	19454	50	NFIA,SOX5
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	TNIK,ABLIM1
2.446e-02	-3.71	regulation of mRNA 3'-end processing	biological process	GO:0031440	9	1	18204	50	AHCYL1
2.446e-02	-3.71	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	50	ATP13A4
2.446e-02	-3.71	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	50	APOE
2.446e-02	-3.71	negative regulation of cellular extravasation	biological process	GO:0002692	9	1	18204	50	PLCB1
2.446e-02	-3.71	macrophage proliferation	biological process	GO:0061517	9	1	18204	50	CLU
2.446e-02	-3.71	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	50	NRXN1
2.446e-02	-3.71	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	50	CTNNA2
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.446e-02	-3.71	sterol catabolic process	biological process	GO:0016127	9	1	18204	50	APOE
2.446e-02	-3.71	microglial cell proliferation	biological process	GO:0061518	9	1	18204	50	CLU
2.446e-02	-3.71	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	50	CTNNA2
2.446e-02	-3.71	interleukin-12-mediated signaling pathway	biological process	GO:0035722	9	1	18204	50	PLCB1
2.452e-02	-3.71	Band_3_cyto	pfam domains	PF07565	9	1	17795	49	SLC4A4
2.452e-02	-3.71	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	49	RFX4
2.458e-02	-3.71	PROTEIN_KINASE_ST	prosite domains	PS00108	308	4	12186	44	MAPK10,PRKG1,DCLK2,TNIK
2.487e-02	-3.69	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	2	18204	50	APOE,SORBS1
2.494e-02	-3.69	Epithelial cell signaling in Helicobacter pylori infection	KEGG pathways	ko05120	68	2	7161	26	MAPK10,PTPRZ1
2.494e-02	-3.69	Epithelial cell signaling in Helicobacter pylori infection	KEGG pathways	hsa05120	68	2	7161	26	PTPRZ1,MAPK10
2.501e-02	-3.69	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	1	12186	44	SLC1A2
2.501e-02	-3.69	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	1	12186	44	SLC1A2
2.534e-02	-3.68	G-Protein Signaling Through Tubby Proteins	SMPDB pathways	SMP0089843	7	1	1369	5	PLCB1
2.534e-02	-3.68	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	5	ADCY2
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	ZNF563 (zinc finger protein 563)	protein interactions	147837	10	1	19454	50	LRP1B
2.541e-02	-3.67	SERPINB11 (serpin family B member 11)	protein interactions	89778	10	1	19454	50	CPE
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	CHRDL1 (chordin like 1)	protein interactions	91851	10	1	19454	50	LRP1B
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.553e-02	-3.67	calcium ion homeostasis	biological process	GO:0055074	231	3	18204	50	RYR3,APOE,ATP13A4
2.585e-02	-3.66	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	3	19454	50	SOX5,TNIK,NFIA
2.587e-02	-3.65	perineuronal net	cellular component	GO:0072534	10	1	19108	50	PTPRZ1
2.631e-02	-3.64	FRAS1 (Fraser extracellular matrix complex subunit 1)	protein interactions	80144	98	2	19454	50	HPSE2,MGAT4C
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	GPM6A,LSAMP
2.631e-02	-3.64	DACH1 (dachshund family transcription factor 1)	protein interactions	1602	98	2	19454	50	SOX5,AHCYL1
2.644e-02	-3.63	actin filament-based process	biological process	GO:0030029	616	5	18204	50	PRKG1,SORBS1,TNIK,NEBL,FMN2
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.648e-02	-3.63	ankle	COSMIC cancer mutations	ankle	398	4	16828	48	NRG3,ATP13A4,PARD3,PLCB1
2.649e-02	-3.63	negative regulation of locomotion	biological process	GO:0040013	413	4	18204	50	PLCB1,APOE,NRG3,PRKG1
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.668e-02	-3.62	Doublecortin_dom_sf	interpro domains	IPR036572	10	1	18521	50	DCLK2
2.668e-02	-3.62	MIP_CS	interpro domains	IPR022357	10	1	18521	50	AQP4
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.676e-02	-3.62	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	49	PITPNC1
2.676e-02	-3.62	neurotrophin binding	molecular function	GO:0043121	10	1	18094	49	NTRK2
2.676e-02	-3.62	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	49	ATP13A4
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	TRPS1,SOX5
2.681e-02	-3.62	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	31	CLU
2.688e-02	-3.62	Diseases of glycosylation	REACTOME pathways	R-HSA-3781865	85	2	10285	31	SPON1,GPC5
2.690e-02	-3.62	anterograde trans-synaptic signaling	biological process	GO:0098916	415	4	18204	50	DTNA,SLC1A2,NRXN1,APOE
2.690e-02	-3.62	chemical synaptic transmission	biological process	GO:0007268	415	4	18204	50	SLC1A2,APOE,NRXN1,DTNA
2.693e-02	-3.61	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	3	19454	50	SORBS1,TNIK,NTRK2
2.693e-02	-3.61	CRX (cone-rod homeobox)	protein interactions	1406	252	3	19454	50	TRPS1,SOX5,NFIA
2.695e-02	-3.61	Calcium signaling pathway	KEGG pathways	hsa04020	181	3	7161	26	RYR3,ADCY2,PLCB1
2.695e-02	-3.61	Calcium signaling pathway	KEGG pathways	ko04020	181	3	7161	26	RYR3,PLCB1,ADCY2
2.697e-02	-3.61	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	3	10285	31	SLC1A2,PLCB1,ADCY2
2.704e-02	-3.61	Doublecortin domain	gene3d domains	3.10.20.230	9	1	14470	44	DCLK2
2.705e-02	-3.61	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	44	ABLIM1,NEBL
2.705e-02	-3.61	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	44	ABLIM1,NEBL
2.714e-02	-3.61	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	50	NTRK2
2.714e-02	-3.61	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	50	APOE
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	50	APOE
2.714e-02	-3.61	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	50	APOE
2.714e-02	-3.61	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	50	APOE
2.714e-02	-3.61	establishment of centrosome localization	biological process	GO:0051660	10	1	18204	50	PARD3
2.714e-02	-3.61	cellular response to cocaine	biological process	GO:0071314	10	1	18204	50	SLC1A2
2.714e-02	-3.61	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	50	NRXN1
2.714e-02	-3.61	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	50	APOE
2.714e-02	-3.61	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	50	NRG3
2.714e-02	-3.61	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	50	APOE
2.714e-02	-3.61	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	1	18204	50	NRXN1
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	retinal rod cell development	biological process	GO:0046548	10	1	18204	50	NTRK2
2.714e-02	-3.61	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	50	NRXN1
2.714e-02	-3.61	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	50	ADCY2
2.714e-02	-3.61	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	50	NRG3
2.714e-02	-3.61	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	50	NTRK2
2.719e-02	-3.60	response to organic cyclic compound	biological process	GO:0014070	843	6	18204	50	RYR3,ATP1A2,ADCY2,PLCB1,SLC1A2,RORA
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.720e-02	-3.60	HCO3_cotransp	pfam domains	PF00955	10	1	17795	49	SLC4A4
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	RYR3
2.731e-02	-3.60	EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2)	protein interactions	55741	100	2	19454	50	HPSE2,CLU
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	ATP1A2,GPM6A
2.731e-02	-3.60	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	50	ABLIM1,NRXN1
2.733e-02	-3.60	positive regulation of transport	biological process	GO:0051050	844	6	18204	50	SLC1A2,AHCYL1,APOE,PLCB1,CLU,SORBS1
2.733e-02	-3.60	Chemokine signaling pathway	KEGG pathways	ko04062	182	3	7161	26	PLCB1,ADCY2,PARD3
2.733e-02	-3.60	Chemokine signaling pathway	KEGG pathways	hsa04062	182	3	7161	26	ADCY2,PLCB1,PARD3
2.738e-02	-3.60	cellular response to chemical stimulus	biological process	GO:0070887	2411	12	18204	50	RYR3,AHCYL1,NTRK2,RORA,ATP1A2,FMN2,AQP4,ADCY2,APOE,PLCB1,SLC1A2,SORBS1
2.746e-02	-3.60	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	3	16828	48	HPSE2,CTNND2,LRP1B
2.756e-02	-3.59	muscle contraction	biological process	GO:0006936	238	3	18204	50	DTNA,RYR3,ATP1A2
2.772e-02	-3.59	EGF_Ca-bd_CS	interpro domains	IPR018097	96	2	18521	50	EFEMP1,LRP1B
2.777e-02	-3.58	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	91	2	16828	48	LRP1B,ADCY2
2.781e-02	-3.58	endomembrane system	cellular component	GO:0012505	4764	19	19108	50	NRXN1,ATP13A4,GPC5,SPON1,AHCYL1,RYR3,AQP4,CPE,FMN2,ATP1A2,PRKG1,NTRK2,CLU,TNIK,APOE,SPARCL1,PARD3,MGAT4C,PLCB1
2.783e-02	-3.58	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	4	10285	31	ADCY2,NTRK2,AHCYL1,NRG3
2.787e-02	-3.58	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	49	ATP1A2,ATP13A4
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	PRKG1
2.792e-02	-3.58	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	50	NRXN1
2.792e-02	-3.58	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	1	19454	50	ADCY2
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.792e-02	-3.58	NTS (neurotensin)	protein interactions	4922	11	1	19454	50	CPE
2.793e-02	-3.58	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	13	16828	48	TRPM3,CPE,GPC5,AHCYL1,LRP1B,NRG3,NRXN1,FMN2,TRPS1,ADCY2,RORA,PTPRZ1,PARD3
2.795e-02	-3.58	lipid binding	molecular function	GO:0008289	861	6	18094	49	PARD3,RORA,ATP1A2,APOE,PLCB1,PITPNC1
2.796e-02	-3.58	Phenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000327	77	2	1369	5	PLCB1,ATP1A2
2.807e-02	-3.57	cardiac muscle cell differentiation	biological process	GO:0055007	95	2	18204	50	NEBL,PRKG1
2.807e-02	-3.57	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	50	RYR3,PLCB1
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	ZSCAN21 (zinc finger and SCAN domain containing 21)	protein interactions	7589	102	2	19454	50	LRP1B,EFEMP1
2.832e-02	-3.56	TMPRSS13 (transmembrane serine protease 13)	protein interactions	84000	102	2	19454	50	CPE,SPON1
2.832e-02	-3.56	KRTAP6-1 (keratin associated protein 6-1)	protein interactions	337966	102	2	19454	50	GLIS3,EFEMP1
2.834e-02	-3.56	protein serine/threonine kinase activity	molecular function	GO:0004674	428	4	18094	49	MAPK10,PRKG1,TNIK,DCLK2
2.842e-02	-3.56	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	50	PTPRZ1
2.851e-02	-3.56	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	5	12186	44	TNIK,DCLK2,PRKG1,MAPK10,NTRK2
2.853e-02	-3.56	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	44	TRPS1
2.853e-02	-3.56	HP	prosite domains	PS51089	8	1	12186	44	ABLIM1
2.862e-02	-3.55	negative regulation of response to wounding	biological process	GO:1903035	96	2	18204	50	PRKG1,APOE
2.863e-02	-3.55	functioning	COSMIC cancer mutations	functioning	1803	10	16828	48	RFX4,SOX5,NRG3,TRPM3,PTPRZ1,HPSE2,SLC1A2,EFEMP1,FMN2,NTRK2
2.863e-02	-3.55	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	10	16828	48	RFX4,NRG3,TRPM3,SOX5,PTPRZ1,HPSE2,EFEMP1,FMN2,NTRK2,SLC1A2
2.884e-02	-3.55	ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)	protein interactions	25921	103	2	19454	50	PARD3,NTRK2
2.891e-02	-3.54	aldosterone_producing	COSMIC cancer mutations	aldosterone_producing	93	2	16828	48	ADCY2,LRP1B
2.892e-02	-3.54	Buclizine H1-Antihistamine Action	SMPDB pathways	SMP0058964	8	1	1369	5	PLCB1
2.892e-02	-3.54	Thiazinamium H1-Antihistamine Action	SMPDB pathways	SMP0060742	8	1	1369	5	PLCB1
2.892e-02	-3.54	Meclizine H1-Antihistamine Action	SMPDB pathways	SMP0058956	8	1	1369	5	PLCB1
2.892e-02	-3.54	Flunarizine H1-Antihistamine Action	SMPDB pathways	SMP0061047	8	1	1369	5	PLCB1
2.892e-02	-3.54	Tripelennamine H1-Antihistamine Action	SMPDB pathways	SMP0057587	8	1	1369	5	PLCB1
2.892e-02	-3.54	Fenethazine H1-Antihistamine Action	SMPDB pathways	SMP0059707	8	1	1369	5	PLCB1
2.892e-02	-3.54	Hydroxyzine H1-Antihistamine Action	SMPDB pathways	SMP0058936	8	1	1369	5	PLCB1
2.892e-02	-3.54	Diphenylpyraline H1-Antihistamine Action	SMPDB pathways	SMP0058908	8	1	1369	5	PLCB1
2.892e-02	-3.54	Phenindamine H1-Antihistamine Action	SMPDB pathways	SMP0061190	8	1	1369	5	PLCB1
2.892e-02	-3.54	Propiomazine H1-Antihistamine Action	SMPDB pathways	SMP0062625	8	1	1369	5	PLCB1
2.892e-02	-3.54	Latrepirdine H1-Antihistamine Action	SMPDB pathways	SMP0062623	8	1	1369	5	PLCB1
2.892e-02	-3.54	Chlorphenoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058903	8	1	1369	5	PLCB1
2.892e-02	-3.54	Epinastine H1-Antihistamine Action	SMPDB pathways	SMP0061191	8	1	1369	5	PLCB1
2.892e-02	-3.54	Fexofenadine H1-Antihistamine Action	SMPDB pathways	SMP0060218	8	1	1369	5	PLCB1
2.892e-02	-3.54	Homochlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0062795	8	1	1369	5	PLCB1
2.892e-02	-3.54	Levocetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059114	8	1	1369	5	PLCB1
2.892e-02	-3.54	Thenyldiamine H1-Antihistamine Action	SMPDB pathways	SMP0062624	8	1	1369	5	PLCB1
2.892e-02	-3.54	Chlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058931	8	1	1369	5	PLCB1
2.892e-02	-3.54	Tolpropamine H1-Antihistamine Action	SMPDB pathways	SMP0062621	8	1	1369	5	PLCB1
2.892e-02	-3.54	Cinnarizine H1-Antihistamine Action	SMPDB pathways	SMP0059110	8	1	1369	5	PLCB1
2.892e-02	-3.54	Brompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057579	8	1	1369	5	PLCB1
2.892e-02	-3.54	Bepotastine H1-Antihistamine Action	SMPDB pathways	SMP0060058	8	1	1369	5	PLCB1
2.892e-02	-3.54	Clemastine H1-Antihistamine Action	SMPDB pathways	SMP0058891	8	1	1369	5	PLCB1
2.892e-02	-3.54	Promethazine H1-Antihistamine Action	SMPDB pathways	SMP0059211	8	1	1369	5	PLCB1
2.892e-02	-3.54	Orphenadrine H1-Antihistamine Action	SMPDB pathways	SMP0058808	8	1	1369	5	PLCB1
2.892e-02	-3.54	Bamipine H1-Antihistamine Action	SMPDB pathways	SMP0062882	8	1	1369	5	PLCB1
2.892e-02	-3.54	Antazoline H1-Antihistamine Action	SMPDB pathways	SMP0057584	8	1	1369	5	PLCB1
2.892e-02	-3.54	Mebhydrolin H1-Antihistamine Action	SMPDB pathways	SMP0061052	8	1	1369	5	PLCB1
2.892e-02	-3.54	Triprolidine H1-Antihistamine Action	SMPDB pathways	SMP0057581	8	1	1369	5	PLCB1
2.892e-02	-3.54	Methdilazine H1-Antihistamine Action	SMPDB pathways	SMP0059730	8	1	1369	5	PLCB1
2.892e-02	-3.54	Doxylamine H1-Antihistamine Action	SMPDB pathways	SMP0058803	8	1	1369	5	PLCB1
2.892e-02	-3.54	Chlorphenamine H1-Antihistamine Action	SMPDB pathways	SMP0056661	8	1	1369	5	PLCB1
2.892e-02	-3.54	Emedastine H1-Antihistamine Action	SMPDB pathways	SMP0061040	8	1	1369	5	PLCB1
2.892e-02	-3.54	Dexbrompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057580	8	1	1369	5	PLCB1
2.892e-02	-3.54	Cetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059058	8	1	1369	5	PLCB1
2.892e-02	-3.54	Levocabastine H1-Antihistamine Action	SMPDB pathways	SMP0060224	8	1	1369	5	PLCB1
2.892e-02	-3.54	Oxomemazine H1-Antihistamine Action	SMPDB pathways	SMP0059738	8	1	1369	5	PLCB1
2.892e-02	-3.54	Talastine H1-Antihistamine Action	SMPDB pathways	SMP0057586	8	1	1369	5	PLCB1
2.892e-02	-3.54	Histapyrrodine H1-Antihistamine Action	SMPDB pathways	SMP0058732	8	1	1369	5	PLCB1
2.892e-02	-3.54	Clocinizine H1-Antihistamine Action	SMPDB pathways	SMP0062788	8	1	1369	5	PLCB1
2.892e-02	-3.54	Methapyrilene H1-Antihistamine Action	SMPDB pathways	SMP0058741	8	1	1369	5	PLCB1
2.892e-02	-3.54	Mepyramine H1-Antihistamine Action	SMPDB pathways	SMP0057583	8	1	1369	5	PLCB1
2.892e-02	-3.54	Chloropyramine H1-Antihistamine Action	SMPDB pathways	SMP0057585	8	1	1369	5	PLCB1
2.892e-02	-3.54	Doxepin H1-Antihistamine Action	SMPDB pathways	SMP0059872	8	1	1369	5	PLCB1
2.892e-02	-3.54	Ebastine H1-Antihistamine Action	SMPDB pathways	SMP0060204	8	1	1369	5	PLCB1
2.892e-02	-3.54	Pyrrobutamine H1-Antihistamine Action	SMPDB pathways	SMP0062887	8	1	1369	5	PLCB1
2.892e-02	-3.54	Betahistine H1-Antihistamine Action	SMPDB pathways	SMP0060744	8	1	1369	5	PLCB1
2.892e-02	-3.54	Dexchlorpheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056811	8	1	1369	5	PLCB1
2.892e-02	-3.54	Phenyltoloxamine H1-Antihistamine Action	SMPDB pathways	SMP0058916	8	1	1369	5	PLCB1
2.892e-02	-3.54	Thenalidine H1-Antihistamine Action	SMPDB pathways	SMP0062894	8	1	1369	5	PLCB1
2.892e-02	-3.54	Carbinoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058797	8	1	1369	5	PLCB1
2.892e-02	-3.54	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	5	ADCY2
2.892e-02	-3.54	Olopatadine H1-Antihistamine Action	SMPDB pathways	SMP0060740	8	1	1369	5	PLCB1
2.892e-02	-3.54	Cyproheptadine H1-Antihistamine Action	SMPDB pathways	SMP0059694	8	1	1369	5	PLCB1
2.892e-02	-3.54	Mizolastine H1-Antihistamine Action	SMPDB pathways	SMP0060230	8	1	1369	5	PLCB1
2.892e-02	-3.54	Histamine H1 Receptor Activation	SMPDB pathways	SMP0063452	8	1	1369	5	PLCB1
2.892e-02	-3.54	Desloratadine H1-Antihistamine Action	SMPDB pathways	SMP0060201	8	1	1369	5	PLCB1
2.892e-02	-3.54	Azelastine H1-Antihistamine Action	SMPDB pathways	SMP0060741	8	1	1369	5	PLCB1
2.892e-02	-3.54	Terfenadine H1-Antihistamine Action	SMPDB pathways	SMP0060208	8	1	1369	5	PLCB1
2.892e-02	-3.54	Astemizole H1-Antihistamine Action	SMPDB pathways	SMP0059897	8	1	1369	5	PLCB1
2.892e-02	-3.54	Embramine H1-Antihistamine Action	SMPDB pathways	SMP0062622	8	1	1369	5	PLCB1
2.892e-02	-3.54	Diphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058785	8	1	1369	5	PLCB1
2.892e-02	-3.54	Rupatadine H1-Antihistamine Action	SMPDB pathways	SMP0060235	8	1	1369	5	PLCB1
2.892e-02	-3.54	Quifenadine H1-Antihistamine Action	SMPDB pathways	SMP0060743	8	1	1369	5	PLCB1
2.892e-02	-3.54	Mequitazine H1-Antihistamine Action	SMPDB pathways	SMP0059720	8	1	1369	5	PLCB1
2.892e-02	-3.54	Acrivastine H1-Antihistamine Action	SMPDB pathways	SMP0059881	8	1	1369	5	PLCB1
2.892e-02	-3.54	Tritoqualine H1-Antihistamine Action	SMPDB pathways	SMP0062895	8	1	1369	5	PLCB1
2.892e-02	-3.54	Bilastine H1-Antihistamine Action	SMPDB pathways	SMP0060170	8	1	1369	5	PLCB1
2.892e-02	-3.54	Pheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056662	8	1	1369	5	PLCB1
2.892e-02	-3.54	Azatadine H1-Antihistamine Action	SMPDB pathways	SMP0059865	8	1	1369	5	PLCB1
2.892e-02	-3.54	Quetiapine H1-Antihistamine Action	SMPDB pathways	SMP0062884	8	1	1369	5	PLCB1
2.892e-02	-3.54	Phenbenzamine H1-Antihistamine Action	SMPDB pathways	SMP0059702	8	1	1369	5	PLCB1
2.892e-02	-3.54	Dimetindene H1-Antihistamine Action	SMPDB pathways	SMP0057582	8	1	1369	5	PLCB1
2.892e-02	-3.54	Alcaftadine H1-Antihistamine Action	SMPDB pathways	SMP0062881	8	1	1369	5	PLCB1
2.892e-02	-3.54	Ketotifen H1-Antihistamine Action	SMPDB pathways	SMP0059868	8	1	1369	5	PLCB1
2.892e-02	-3.54	Hydroxyethylpromethazine H1-Antihistamine Action	SMPDB pathways	SMP0059710	8	1	1369	5	PLCB1
2.892e-02	-3.54	Temelastine H1-Antihistamine Action	SMPDB pathways	SMP0062880	8	1	1369	5	PLCB1
2.892e-02	-3.54	Oxatomide H1-Antihistamine Action	SMPDB pathways	SMP0059044	8	1	1369	5	PLCB1
2.892e-02	-3.54	Bromodiphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058813	8	1	1369	5	PLCB1
2.892e-02	-3.54	Lysophosphatidic Acid LPA3 Signalling	SMPDB pathways	SMP0063755	8	1	1369	5	PLCB1
2.892e-02	-3.54	Isothipendyl H1-Antihistamine Action	SMPDB pathways	SMP0059716	8	1	1369	5	PLCB1
2.892e-02	-3.54	Pimethixene H1-Antihistamine Action	SMPDB pathways	SMP0062886	8	1	1369	5	PLCB1
2.892e-02	-3.54	Thonzylamine H1-Antihistamine Action	SMPDB pathways	SMP0058769	8	1	1369	5	PLCB1
2.892e-02	-3.54	Deptropine H1-Antihistamine Action	SMPDB pathways	SMP0062883	8	1	1369	5	PLCB1
2.892e-02	-3.54	Alimemazine H1-Antihistamine Action	SMPDB pathways	SMP0059689	8	1	1369	5	PLCB1
2.892e-02	-3.54	Cyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058923	8	1	1369	5	PLCB1
2.892e-02	-3.54	Mirtazapine H1-Antihistamine Action	SMPDB pathways	SMP0062885	8	1	1369	5	PLCB1
2.892e-02	-3.54	Loratadine H1-Antihistamine Action	SMPDB pathways	SMP0060195	8	1	1369	5	PLCB1
2.907e-02	-3.54	viral process	biological process	GO:0016032	243	3	18204	50	MGAT4C,APOE,NFIA
2.917e-02	-3.53	positive regulation of JNK cascade	biological process	GO:0046330	97	2	18204	50	PLCB1,TNIK
2.920e-02	-3.53	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	4	19454	50	CTNND2,FMN2,PARD3,DTNA
2.920e-02	-3.53	FGFR4 (fibroblast growth factor receptor 4)	protein interactions	2264	455	4	19454	50	TNIK,SORBS1,AHCYL1,ABLIM1
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.936e-02	-3.53	MFHAS1 (multifunctional ROCO family signaling regulator 1)	protein interactions	9258	104	2	19454	50	ABLIM1,AHCYL1
2.937e-02	-3.53	regulation of neuron apoptotic process	biological process	GO:0043523	244	3	18204	50	NTRK2,CLU,PTPRZ1
2.940e-02	-3.53	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	49	NRXN1
2.940e-02	-3.53	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	49	SLC1A2
2.946e-02	-3.52	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	3	19454	50	PARD3,DTNA,FMN2
2.952e-02	-3.52	anchoring junction	cellular component	GO:0070161	902	6	19108	50	PARD3,CTNNA2,CDH20,ATP1A2,CTNND2,SORBS1
2.968e-02	-3.52	negative regulation of response to external stimulus	biological process	GO:0032102	428	4	18204	50	PRKG1,CTNNA2,RORA,APOE
2.974e-02	-3.52	LIM	smart domains	SM00132	71	2	9717	37	NEBL,ABLIM1
2.975e-02	-3.51	Acetylcholine regulates insulin secretion	REACTOME pathways	R-HSA-399997	10	1	10285	31	PLCB1
2.975e-02	-3.51	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	31	ADCY2
2.975e-02	-3.51	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	31	NRG3
2.975e-02	-3.51	Activation of the AP-1 family of transcription factors	REACTOME pathways	R-HSA-450341	10	1	10285	31	MAPK10
2.975e-02	-3.51	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	31	SLC4A4
2.981e-02	-3.51	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	50	APOE
2.981e-02	-3.51	pyramidal neuron development	biological process	GO:0021860	11	1	18204	50	DCLK2
2.981e-02	-3.51	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	50	NRG3
2.981e-02	-3.51	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	50	NRG3
2.981e-02	-3.51	L-glutamate import across plasma membrane	biological process	GO:0098712	11	1	18204	50	SLC1A2
2.981e-02	-3.51	cellular response to interleukin-12	biological process	GO:0071349	11	1	18204	50	PLCB1
2.981e-02	-3.51	interleukin-15-mediated signaling pathway	biological process	GO:0035723	11	1	18204	50	PLCB1
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	ectodermal placode formation	biological process	GO:0060788	11	1	18204	50	NRG3
2.981e-02	-3.51	physiological cardiac muscle hypertrophy	biological process	GO:0003301	11	1	18204	50	PRKG1
2.981e-02	-3.51	L-aspartate transmembrane transport	biological process	GO:0070778	11	1	18204	50	SLC1A2
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	polyamine transport	biological process	GO:0015846	11	1	18204	50	ATP13A4
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.981e-02	-3.51	positive regulation of acrosome reaction	biological process	GO:2000344	11	1	18204	50	PLCB1
2.981e-02	-3.51	cell growth involved in cardiac muscle cell development	biological process	GO:0061049	11	1	18204	50	PRKG1
2.981e-02	-3.51	regulation of fear response	biological process	GO:1903365	11	1	18204	50	APOE
2.981e-02	-3.51	physiological muscle hypertrophy	biological process	GO:0003298	11	1	18204	50	PRKG1
2.981e-02	-3.51	glutamate secretion	biological process	GO:0014047	11	1	18204	50	NTRK2
2.981e-02	-3.51	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	50	PRKG1
2.981e-02	-3.51	cellular response to interleukin-15	biological process	GO:0071350	11	1	18204	50	PLCB1
2.981e-02	-3.51	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	50	APOE
2.981e-02	-3.51	egg activation	biological process	GO:0007343	11	1	18204	50	PLCB1
2.988e-02	-3.51	ZNF444 (zinc finger protein 444)	protein interactions	55311	105	2	19454	50	AHCYL1,EFEMP1
2.988e-02	-3.51	BEND3 (BEN domain containing 3)	protein interactions	57673	105	2	19454	50	TRPS1,TNIK
2.988e-02	-3.51	ANP32E (acidic nuclear phosphoprotein 32 family member E)	protein interactions	81611	105	2	19454	50	PARD3,AHCYL1
3.000e-02	-3.51	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	44	SLC4A4
3.007e-02	-3.50	VHP	smart domains	SM00153	8	1	9717	37	ABLIM1
3.028e-02	-3.50	phospholipid transport	biological process	GO:0015914	99	2	18204	50	PITPNC1,APOE
3.040e-02	-3.49	USP6NL (USP6 N-terminal like)	protein interactions	9712	106	2	19454	50	PARD3,NTRK2
3.042e-02	-3.49	HUDSXLRNA	prints domains	PR00961	7	1	5227	23	RBMS3
3.042e-02	-3.49	EDTRNSPORT	prints domains	PR00173	7	1	5227	23	SLC1A2
3.042e-02	-3.49	OAS2 (2'-5'-oligoadenylate synthetase 2)	protein interactions	4939	12	1	19454	50	PRKG1
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	KIF26A (kinesin family member 26A)	protein interactions	26153	12	1	19454	50	MAPK10
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	Pard6b (par-6 family cell polarity regulator beta)	protein interactions	58220	12	1	19454	50	PARD3
3.074e-02	-3.48	regulation of transport	biological process	GO:0051049	1621	9	18204	50	SLC1A2,AHCYL1,PLCB1,APOE,PRKG1,SORBS1,CLU,ATP1A2,NKAIN3
3.079e-02	-3.48	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	50	ATP1A2,RYR3,APOE,ATP13A4
3.085e-02	-3.48	response to alkaloid	biological process	GO:0043279	100	2	18204	50	RYR3,SLC1A2
3.096e-02	-3.48	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	50	PTPRZ1
3.096e-02	-3.48	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	50	ATP1A2
3.097e-02	-3.47	extracellular vesicle	cellular component	GO:1903561	2278	11	19108	50	SLC4A4,ATP1A2,GPM6A,PLCB1,NEBL,CPE,APOE,TNIK,CLU,AHCYL1,EFEMP1
3.106e-02	-3.47	extracellular organelle	cellular component	GO:0043230	2279	11	19108	50	SLC4A4,ATP1A2,GPM6A,APOE,PLCB1,NEBL,CPE,AHCYL1,EFEMP1,TNIK,CLU
3.106e-02	-3.47	extracellular membrane-bounded organelle	cellular component	GO:0065010	2279	11	19108	50	SLC4A4,ATP1A2,GPM6A,PLCB1,CPE,NEBL,APOE,TNIK,CLU,AHCYL1,EFEMP1
3.107e-02	-3.47	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	4	19454	50	PLCB1,CTNNA2,AHCYL1,TNIK
3.125e-02	-3.47	cellular response to peptide hormone stimulus	biological process	GO:0071375	250	3	18204	50	PLCB1,AHCYL1,SORBS1
3.142e-02	-3.46	cholesterol homeostasis	biological process	GO:0042632	101	2	18204	50	APOE,RORA
3.142e-02	-3.46	regulation of carbohydrate biosynthetic process	biological process	GO:0043255	101	2	18204	50	SORBS1,PRKG1
3.142e-02	-3.46	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	50	SORBS1,RORA
3.147e-02	-3.46	PAX8 (paired box 8)	protein interactions	7849	108	2	19454	50	NFIA,TRPS1
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	CLU,GPM6A
3.147e-02	-3.46	UFM1 (ubiquitin fold modifier 1)	protein interactions	51569	108	2	19454	50	MSI2,AHCYL1
3.147e-02	-3.46	CAMKV (CaM kinase like vesicle associated)	protein interactions	79012	108	2	19454	50	GPM6A,AHCYL1
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	RYR3,MSI2
3.153e-02	-3.46	MEOX2 (mesenchyme homeobox 2)	protein interactions	4223	690	5	19454	50	PRKG1,SPON1,EFEMP1,AHCYL1,MSI2
3.182e-02	-3.45	ear	COSMIC cancer mutations	ear	624	5	16828	48	LRP1B,MGAT4C,SPARCL1,PRKG1,NPAS3
3.183e-02	-3.45	active transmembrane transporter activity	molecular function	GO:0022804	444	4	18094	49	ATP1A2,SLC1A2,ATP13A4,SLC4A4
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.193e-02	-3.44	PLC_EF-hand-like	interpro domains	IPR015359	12	1	18521	50	PLCB1
3.193e-02	-3.44	MAP_kinase_CS	interpro domains	IPR003527	12	1	18521	50	MAPK10
3.199e-02	-3.44	sterol homeostasis	biological process	GO:0055092	102	2	18204	50	RORA,APOE
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	SOX5,TRPM3
3.203e-02	-3.44	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	49	ADCY2
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.204e-02	-3.44	RFX_DBD	prosite domains	PS51526	9	1	12186	44	RFX4
3.204e-02	-3.44	DC	prosite domains	PS50309	9	1	12186	44	DCLK2
3.222e-02	-3.44	Heparan sulfate degradation	KEGG pathways	M00078	9	1	7161	26	HPSE2
3.222e-02	-3.44	Heparan sulfate degradation	KEGG pathways	hsa_M00078	9	1	7161	26	HPSE2
3.222e-02	-3.44	cGMP signaling	KEGG pathways	hsa_M00694	9	1	7161	26	PRKG1
3.222e-02	-3.44	cGMP signaling	KEGG pathways	M00694	9	1	7161	26	PRKG1
3.240e-02	-3.43	EGF	smart domains	SM00181	184	3	9717	37	NRXN1,LRP1B,EFEMP1
3.248e-02	-3.43	response to interleukin-15	biological process	GO:0070672	12	1	18204	50	PLCB1
3.248e-02	-3.43	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	50	SLC1A2
3.248e-02	-3.43	auditory behavior	biological process	GO:0031223	12	1	18204	50	NRXN1
3.248e-02	-3.43	epithelial fluid transport	biological process	GO:0042045	12	1	18204	50	AHCYL1
3.248e-02	-3.43	response to interleukin-12	biological process	GO:0070671	12	1	18204	50	PLCB1
3.248e-02	-3.43	negative regulation of smooth muscle contraction	biological process	GO:0045986	12	1	18204	50	PRKG1
3.248e-02	-3.43	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	50	APOE
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	5	ADCY2
3.249e-02	-3.43	Lysophosphatidic Acid LPA1 Signalling	SMPDB pathways	SMP0063746	9	1	1369	5	PLCB1
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	5	ADCY2
3.249e-02	-3.43	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	5	ADCY2
3.249e-02	-3.43	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	5	ADCY2
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	5	ADCY2
3.249e-02	-3.43	Lysophosphatidic Acid LPA2 Signalling	SMPDB pathways	SMP0063753	9	1	1369	5	PLCB1
3.256e-02	-3.42	MH1	pfam domains	PF03165	12	1	17795	49	NFIA
3.256e-02	-3.42	EF-hand_like	pfam domains	PF09279	12	1	17795	49	PLCB1
3.256e-02	-3.42	CarboxypepD_reg	pfam domains	PF13620	12	1	17795	49	CPE
3.257e-02	-3.42	cerebellum development	biological process	GO:0021549	103	2	18204	50	PRKG1,RORA
3.271e-02	-3.42	RDX (radixin)	protein interactions	5962	272	3	19454	50	MAPK10,NEBL,ABLIM1
3.291e-02	-3.41	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	50	APOE
3.291e-02	-3.41	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	50	NRXN1
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	DDIAS (DNA damage induced apoptosis suppressor)	protein interactions	220042	13	1	19454	50	EFEMP1
3.291e-02	-3.41	RNASE4 (ribonuclease A family member 4)	protein interactions	6038	13	1	19454	50	LRP1B
3.291e-02	-3.41	JAM2 (junctional adhesion molecule 2)	protein interactions	58494	13	1	19454	50	PARD3
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.296e-02	-3.41	Carboxypeptidase-like, regulatory domain	gene3d domains	2.60.40.1120	11	1	14470	44	CPE
3.302e-02	-3.41	FLOT2 (flotillin 2)	protein interactions	2319	273	3	19454	50	NTRK2,PARD3,SOX5
3.308e-02	-3.41	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	50	CTNNA2,NTRK2,APOE,TNIK
3.350e-02	-3.40	chylomicron	cellular component	GO:0042627	13	1	19108	50	APOE
3.350e-02	-3.40	postsynaptic cytosol	cellular component	GO:0099524	13	1	19108	50	PLCB1
3.363e-02	-3.39	TSC22D4 (TSC22 domain family member 4)	protein interactions	81628	112	2	19454	50	ABLIM1,CLU
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	GPM6A,AHCYL1
3.372e-02	-3.39	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	37	16828	48	DTNA,CDH20,ADCY2,PRKG1,ATP1A2,MSI2,NEBL,NRG3,TNIK,DCLK2,PLCB1,EFEMP1,SLC4A4,RYR3,MGAT4C,SLC1A2,NPAS3,ATP13A4,CTNND2,PTPRZ1,PARD3,TRPS1,FMN2,RORA,SORBS1,CLU,GLIS3,NRXN1,LRP1B,AHCYL1,HPSE2,GPC5,NTRK2,LSAMP,TRPM3,SOX5,CPE
3.373e-02	-3.39	response to interleukin-1	biological process	GO:0070555	105	2	18204	50	RORA,PLCB1
3.377e-02	-3.39	FOLN	smart domains	SM00274	9	1	9717	37	SPARCL1
3.377e-02	-3.39	DCX	smart domains	SM00537	9	1	9717	37	DCLK2
3.383e-02	-3.39	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	48	DCLK2,PRKG1,TNIK,NTRK2
3.383e-02	-3.39	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	48	PRKG1,DCLK2,TNIK,NTRK2
3.388e-02	-3.38	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	28	16828	48	NPAS3,ATP13A4,CTNND2,SPARCL1,NKAIN3,DCLK2,RYR3,SLC4A4,ATP1A2,PRKG1,TNIK,NRG3,NEBL,DTNA,ADCY2,SOX5,TRPM3,ABLIM1,NTRK2,GLIS3,NRXN1,SORBS1,LRP1B,PARD3,PTPRZ1,RORA,TRPS1,FMN2
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.392e-02	-3.38	cAMP signaling pathway	KEGG pathways	hsa04024	198	3	7161	26	ATP1A2,MAPK10,ADCY2
3.392e-02	-3.38	cAMP signaling pathway	KEGG pathways	ko04024	198	3	7161	26	MAPK10,ATP1A2,ADCY2
3.398e-02	-3.38	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	3	16828	48	GLIS3,PTPRZ1,MGAT4C
3.402e-02	-3.38	steroid binding	molecular function	GO:0005496	107	2	18094	49	RORA,ATP1A2
3.405e-02	-3.38	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	6	19454	50	TRPS1,ATP13A4,PLCB1,ADCY2,NFIA,CTNND2
3.418e-02	-3.38	transferase activity, transferring phosphorus-containing groups	molecular function	GO:0016772	903	6	18094	49	NTRK2,TNIK,EFEMP1,DCLK2,PRKG1,MAPK10
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	DTNA,EFEMP1
3.457e-02	-3.36	TJP2 (tight junction protein 2)	protein interactions	9414	278	3	19454	50	PARD3,SORBS1,NEBL
3.460e-02	-3.36	phosphatidylinositol bisphosphate binding	molecular function	GO:1902936	108	2	18094	49	PLCB1,PARD3
3.465e-02	-3.36	potassium ion binding	molecular function	GO:0030955	13	1	18094	49	ATP1A2
3.465e-02	-3.36	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	49	SLC4A4
3.469e-02	-3.36	GATAZNFINGER	prints domains	PR00619	8	1	5227	23	TRPS1
3.469e-02	-3.36	negative regulation of protein metabolic process	biological process	GO:0051248	893	6	18204	50	APOE,NTRK2,FMN2,CLU,SPON1,PARD3
3.474e-02	-3.36	PTP4A2 (protein tyrosine phosphatase 4A2)	protein interactions	8073	114	2	19454	50	FMN2,AHCYL1
3.494e-02	-3.35	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	14	16828	48	ADCY2,SLC4A4,NTRK2,FMN2,PARD3,SPARCL1,TRPM3,NRG3,NEBL,LRP1B,MSI2,NPAS3,ATP1A2,PRKG1
3.494e-02	-3.35	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	14	16828	48	PARD3,ADCY2,FMN2,MSI2,ATP1A2,PRKG1,LRP1B,NRG3,NEBL,SPARCL1,NTRK2,SLC4A4,NPAS3,TRPM3
3.496e-02	-3.35	response to organic substance	biological process	GO:0010033	2498	12	18204	50	RYR3,TNIK,ATP1A2,AHCYL1,NTRK2,RORA,AQP4,CLU,SORBS1,ADCY2,PLCB1,SLC1A2
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	RYR3,TRPM3
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	50	RORA
3.514e-02	-3.35	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	50	APOE
3.514e-02	-3.35	ectodermal placode development	biological process	GO:0071696	13	1	18204	50	NRG3
3.514e-02	-3.35	phospholipid efflux	biological process	GO:0033700	13	1	18204	50	APOE
3.514e-02	-3.35	glial cell fate commitment	biological process	GO:0021781	13	1	18204	50	NFIA
3.514e-02	-3.35	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	50	RORA
3.514e-02	-3.35	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	50	NRXN1
3.514e-02	-3.35	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	50	PRKG1
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	prepulse inhibition	biological process	GO:0060134	13	1	18204	50	CTNNA2
3.514e-02	-3.35	defense response to tumor cell	biological process	GO:0002357	13	1	18204	50	RBMS3
3.521e-02	-3.35	organelle organization	biological process	GO:0006996	3091	14	18204	50	PRKG1,CTNNA2,NEBL,NRXN1,TNIK,PARD3,CLU,ABLIM1,DCLK2,SORBS1,RFX4,NFIA,APOE,FMN2
3.522e-02	-3.35	Ldl_recept_b	pfam domains	PF00058	13	1	17795	49	LRP1B
3.524e-02	-3.35	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	19	APOE
3.525e-02	-3.35	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	2	7161	26	ADCY2,PLCB1
3.525e-02	-3.35	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	2	7161	26	ADCY2,PLCB1
3.527e-02	-3.34	ACTB (actin beta)	protein interactions	60	958	6	19454	50	DTNA,ABLIM1,SORBS1,APOE,FMN2,NEBL
3.530e-02	-3.34	CDH2 (cadherin 2)	protein interactions	1000	115	2	19454	50	CTNND2,PARD3
3.530e-02	-3.34	SULF2 (sulfatase 2)	protein interactions	55959	115	2	19454	50	LRP1B,SPON1
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	PARD3,SOX5
3.530e-02	-3.34	DTNA (dystrobrevin alpha)	protein interactions	1837	115	2	19454	50	PARD3,NTRK2
3.530e-02	-3.34	TBXT (T-box transcription factor T)	protein interactions	6862	115	2	19454	50	TRPS1,NFIA
3.533e-02	-3.34	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	50	TNIK,APOE,NTRK2,CTNNA2,GPM6A
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	SYT5 (synaptotagmin 5)	protein interactions	6861	14	1	19454	50	NRXN1
3.540e-02	-3.34	GAGE1 (G antigen 1)	protein interactions	2543	14	1	19454	50	PRKG1
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.540e-02	-3.34	ZNF628 (zinc finger protein 628)	protein interactions	89887	14	1	19454	50	EFEMP1
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	LRP1B
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	FBXL7 (F-box and leucine rich repeat protein 7)	protein interactions	23194	14	1	19454	50	AHCYL1
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	50	APOE
3.551e-02	-3.34	EPHA7 (EPH receptor A7)	protein interactions	2045	281	3	19454	50	PARD3,AHCYL1,TNIK
3.554e-02	-3.34	MIP	prosite domains	PS00221	10	1	12186	44	AQP4
3.554e-02	-3.34	MIR	prosite domains	PS50919	10	1	12186	44	RYR3
3.559e-02	-3.34	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	31	GPC5
3.559e-02	-3.34	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	31	GPC5
3.574e-02	-3.33	Methionine degradation	KEGG pathways	hsa_M00035	10	1	7161	26	AHCYL1
3.574e-02	-3.33	Methionine degradation	KEGG pathways	M00035	10	1	7161	26	AHCYL1
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.586e-02	-3.33	RBBP8 (RB binding protein 8, endonuclease)	protein interactions	5932	116	2	19454	50	CLU,CTNNA2
3.589e-02	-3.33	plasma membrane raft	cellular component	GO:0044853	114	2	19108	50	SORBS1,ATP1A2
3.590e-02	-3.33	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	44	CTNNA2
3.603e-02	-3.32	chromaffin granule	cellular component	GO:0042583	14	1	19108	50	CLU
3.605e-02	-3.32	Lysophosphatidic Acid LPA5 Signalling	SMPDB pathways	SMP0063757	10	1	1369	5	PLCB1
3.605e-02	-3.32	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	5	ADCY2
3.605e-02	-3.32	Lysophosphatidic Acid LPA4 Signalling	SMPDB pathways	SMP0063756	10	1	1369	5	PLCB1
3.621e-02	-3.32	regulation of nervous system development	biological process	GO:0051960	456	4	18204	50	NRXN1,NTRK2,PARD3,PTPRZ1
3.627e-02	-3.32	Ion_trans	pfam domains	PF00520	109	2	17795	49	TRPM3,RYR3
3.642e-02	-3.31	SYT6 (synaptotagmin 6)	protein interactions	148281	117	2	19454	50	NRXN1,AHCYL1
3.642e-02	-3.31	ELK3 (ETS transcription factor ELK3)	protein interactions	2004	117	2	19454	50	NFIA,TRPS1
3.642e-02	-3.31	ZMYND19 (zinc finger MYND-type containing 19)	protein interactions	116225	117	2	19454	50	CTNND2,SPON1
3.647e-02	-3.31	HYOU1 (hypoxia up-regulated 1)	protein interactions	10525	284	3	19454	50	EFEMP1,CPE,CLU
3.656e-02	-3.31	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	5	16828	48	DCLK2,PRKG1,TNIK,NTRK2,TRPS1
3.668e-02	-3.31	CAV1 (caveolin 1)	protein interactions	857	719	5	19454	50	FMN2,TNIK,AHCYL1,PARD3,DTNA
3.672e-02	-3.30	positive regulation of cell junction assembly	biological process	GO:1901890	110	2	18204	50	NTRK2,NRXN1
3.680e-02	-3.30	P4HA1 (prolyl 4-hydroxylase subunit alpha 1)	protein interactions	5033	285	3	19454	50	APOE,EFEMP1,DTNA
3.691e-02	-3.30	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	2	10285	31	APOE,GPC5
3.699e-02	-3.30	PLCD3 (phospholipase C delta 3)	protein interactions	113026	118	2	19454	50	AHCYL1,TNIK
3.704e-02	-3.30	blood microparticle	cellular component	GO:0072562	116	2	19108	50	APOE,CLU
3.715e-02	-3.29	LDLR_classB_rpt	interpro domains	IPR000033	14	1	18521	50	LRP1B
3.715e-02	-3.29	MIP	interpro domains	IPR000425	14	1	18521	50	AQP4
3.715e-02	-3.29	Neurexin-like	interpro domains	IPR003585	14	1	18521	50	NRXN1
3.715e-02	-3.29	Aquaporin-like	interpro domains	IPR023271	14	1	18521	50	AQP4
3.727e-02	-3.29	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	1	18094	49	SLC1A2
3.744e-02	-3.29	protein localization	biological process	GO:0008104	1954	10	18204	50	APOE,NRXN1,AHCYL1,DCLK2,CLU,PARD3,LRP1B,TNIK,FMN2,CPE
3.745e-02	-3.28	endoplasmic reticulum	cellular component	GO:0005783	2051	10	19108	50	CLU,RYR3,SPON1,AHCYL1,SPARCL1,APOE,NRXN1,ATP13A4,ATP1A2,FMN2
3.745e-02	-3.28	MIR	smart domains	SM00472	10	1	9717	37	RYR3
3.756e-02	-3.28	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	50	CLU,APOE
3.756e-02	-3.28	ANKRD26 (ankyrin repeat domain containing 26)	protein interactions	22852	119	2	19454	50	PARD3,NTRK2
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.764e-02	-3.28	ErbB signaling pathway	KEGG pathways	hsa04012	85	2	7161	26	MAPK10,NRG3
3.764e-02	-3.28	ErbB signaling pathway	KEGG pathways	ko04012	85	2	7161	26	NRG3,MAPK10
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	50	APOE
3.779e-02	-3.28	response to forskolin	biological process	GO:1904321	14	1	18204	50	ADCY2
3.779e-02	-3.28	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	50	AQP4
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	cellular response to forskolin	biological process	GO:1904322	14	1	18204	50	ADCY2
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	mechanosensory behavior	biological process	GO:0007638	14	1	18204	50	NRXN1
3.779e-02	-3.28	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	50	APOE
3.788e-02	-3.27	DEFB123 (defensin beta 123)	protein interactions	245936	15	1	19454	50	LRP1B
3.788e-02	-3.27	NPR1 (natriuretic peptide receptor 1)	protein interactions	4881	15	1	19454	50	PRKG1
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	OLFM3 (olfactomedin 3)	protein interactions	118427	15	1	19454	50	LRP1B
3.788e-02	-3.27	PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	27344	15	1	19454	50	MGAT4C
3.788e-02	-3.27	MIP	pfam domains	PF00230	14	1	17795	49	AQP4
3.788e-02	-3.27	GATA	pfam domains	PF00320	14	1	17795	49	TRPS1
3.794e-02	-3.27	rhythmic process	biological process	GO:0048511	270	3	18204	50	NTRK2,RORA,MAPK10
3.796e-02	-3.27	regulation of membrane potential	biological process	GO:0042391	463	4	18204	50	NTRK2,NRXN1,ATP1A2,SLC4A4
3.814e-02	-3.27	HOXB9 (homeobox B9)	protein interactions	3219	120	2	19454	50	NFIA,AHCYL1
3.818e-02	-3.27	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	8	16828	48	HPSE2,RYR3,ATP1A2,ATP13A4,LRP1B,TRPM3,CTNND2,CPE
3.836e-02	-3.26	cellular macromolecule localization	biological process	GO:0070727	1962	10	18204	50	NRXN1,APOE,AHCYL1,CLU,DCLK2,PARD3,LRP1B,TNIK,FMN2,CPE
3.838e-02	-3.26	response to organonitrogen compound	biological process	GO:0010243	915	6	18204	50	SLC1A2,PLCB1,AHCYL1,SORBS1,TNIK,RYR3
3.850e-02	-3.26	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	31	AHCYL1
3.850e-02	-3.26	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	31	NRG3
3.850e-02	-3.26	Passive transport by Aquaporins	REACTOME pathways	R-HSA-432047	13	1	10285	31	AQP4
3.855e-02	-3.26	axolemma	cellular component	GO:0030673	15	1	19108	50	SLC1A2
3.855e-02	-3.26	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	50	APOE
3.856e-02	-3.26	metencephalon development	biological process	GO:0022037	113	2	18204	50	RORA,PRKG1
3.866e-02	-3.25	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	49	PITPNC1,PLCB1,PARD3
3.873e-02	-3.25	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	50	CTNNA2,GPM6A,NTRK2,APOE,TNIK
3.873e-02	-3.25	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	41	16828	48	PLCB1,SPARCL1,NKAIN3,MGAT4C,SLC1A2,RYR3,SPON1,GPM6A,EFEMP1,ATP13A4,NPAS3,RFX4,AQP4,CTNND2,ADCY2,CDH20,ATP1A2,PRKG1,NFIA,TNIK,NRG3,NEBL,GPC5,HPSE2,NTRK2,ABLIM1,PITPNC1,CPE,SOX5,TRPM3,LSAMP,PARD3,PTPRZ1,RORA,FMN2,TRPS1,GLIS3,NRXN1,CLU,SORBS1,LRP1B
3.884e-02	-3.25	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	47	16828	48	GPC5,CPE,LSAMP,PARD3,PTPRZ1,CLU,AHCYL1,PLCB1,SPON1,ATP13A4,NPAS3,CTNND2,AQP4,APOE,CDH20,MSI2,ATP1A2,NEBL,HPSE2,NTRK2,PITPNC1,ABLIM1,SOX5,TRPM3,RORA,FMN2,TRPS1,GLIS3,NRXN1,SORBS1,LRP1B,DCLK2,SPARCL1,NKAIN3,MGAT4C,SLC1A2,RYR3,SLC4A4,GPM6A,EFEMP1,RFX4,DTNA,ADCY2,PRKG1,NFIA,TNIK,NRG3
3.893e-02	-3.25	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	31	TRPM3,RYR3
3.898e-02	-3.24	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	3	16828	48	SLC1A2,SOX5,RYR3
3.902e-02	-3.24	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	44	TRPS1
3.902e-02	-3.24	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	44	NTRK2
3.918e-02	-3.24	negative regulation of small molecule metabolic process	biological process	GO:0062014	114	2	18204	50	APOE,PRKG1
3.935e-02	-3.24	skin-acral-malignant_melanoma	COSMIC cancer mutations	skin-acral-malignant_melanoma	264	3	16828	48	CDH20,FMN2,PARD3
3.936e-02	-3.23	Rap1 signaling pathway	KEGG pathways	hsa04015	210	3	7161	26	PARD3,ADCY2,PLCB1
3.936e-02	-3.23	Rap1 signaling pathway	KEGG pathways	ko04015	210	3	7161	26	PLCB1,ADCY2,PARD3
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.943e-02	-3.23	human chr4q32.3	chromosome location	human chr4q32.3	21	1	26134	50	CPE
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.959e-02	-3.23	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	5	RORA
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	1	18521	50	PLCB1
3.975e-02	-3.23	PI-PLC_fam	interpro domains	IPR001192	15	1	18521	50	PLCB1
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.988e-02	-3.22	low-density lipoprotein particle receptor activity	molecular function	GO:0005041	15	1	18094	49	LRP1B
3.988e-02	-3.22	filamin binding	molecular function	GO:0031005	15	1	18094	49	NEBL
3.988e-02	-3.22	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	49	PITPNC1
3.988e-02	-3.22	tropomyosin binding	molecular function	GO:0005523	15	1	18094	49	NEBL
3.988e-02	-3.22	neurexin family protein binding	molecular function	GO:0042043	15	1	18094	49	CPE
3.988e-02	-3.22	GNAQ (G protein subunit alpha q)	protein interactions	2776	123	2	19454	50	GPM6A,PLCB1
3.988e-02	-3.22	ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)	protein interactions	3708	123	2	19454	50	PRKG1,AHCYL1
3.988e-02	-3.22	PAX7 (paired box 7)	protein interactions	5081	123	2	19454	50	TRPS1,NFIA
4.002e-02	-3.22	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	2	18094	49	SLC4A4,SLC1A2
4.019e-02	-3.21	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	8	16828	48	RYR3,HPSE2,CPE,CTNND2,TRPM3,LRP1B,ATP13A4,ATP1A2
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	50	NRXN1
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKG1
4.035e-02	-3.21	SYT4 (synaptotagmin 4)	protein interactions	6860	16	1	19454	50	NRXN1
4.035e-02	-3.21	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	50	NRXN1
4.035e-02	-3.21	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	50	APOE
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	CPE
4.043e-02	-3.21	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	1	18204	50	PRKG1
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.043e-02	-3.21	pyramidal neuron differentiation	biological process	GO:0021859	15	1	18204	50	DCLK2
4.043e-02	-3.21	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	50	APOE
4.043e-02	-3.21	regulation of monoatomic anion transport	biological process	GO:0044070	15	1	18204	50	AHCYL1
4.043e-02	-3.21	synapse maturation	biological process	GO:0060074	15	1	18204	50	NFIA
4.043e-02	-3.21	negative regulation of amino acid transport	biological process	GO:0051956	15	1	18204	50	PRKG1
4.043e-02	-3.21	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	50	NTRK2
4.043e-02	-3.21	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	50	NTRK2
4.043e-02	-3.21	collateral sprouting	biological process	GO:0048668	15	1	18204	50	PRKG1
4.043e-02	-3.21	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	50	RORA
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	exit from mitosis	biological process	GO:0010458	15	1	18204	50	NFIA
4.043e-02	-3.21	regulation of phospholipid transport	biological process	GO:2001138	15	1	18204	50	APOE
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	50	APOE
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	50	SORBS1
4.047e-02	-3.21	GLI4 (GLI family zinc finger 4)	protein interactions	2738	124	2	19454	50	EFEMP1,LRP1B
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.053e-02	-3.21	PI-PLC-Y	pfam domains	PF00387	15	1	17795	49	PLCB1
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	FMN2
4.055e-02	-3.21	positive regulation of MAPK cascade	biological process	GO:0043410	473	4	18204	50	APOE,PLCB1,NTRK2,TNIK
4.059e-02	-3.20	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	48	NTRK2,TNIK,PRKG1,DCLK2
4.061e-02	-3.20	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	47	16828	48	RFX4,DCLK2,SPARCL1,SLC1A2,MGAT4C,RYR3,SLC4A4,GPM6A,EFEMP1,PRKG1,NFIA,TNIK,NRG3,DTNA,ADCY2,SOX5,TRPM3,HPSE2,NTRK2,ABLIM1,PITPNC1,NRXN1,GLIS3,SORBS1,LRP1B,RORA,TRPS1,FMN2,ATP13A4,NPAS3,CTNND2,AQP4,PLCB1,SPON1,MSI2,ATP1A2,NEBL,APOE,RBMS3,CDH20,CPE,LSAMP,GPC5,CLU,AHCYL1,PARD3,PTPRZ1
4.079e-02	-3.20	TJP1 (tight junction protein 1)	protein interactions	7082	297	3	19454	50	NEBL,DTNA,PARD3
4.079e-02	-3.20	SP7 (Sp7 transcription factor)	protein interactions	121340	297	3	19454	50	NFIA,TRPS1,SOX5
4.080e-02	-3.20	actin filament organization	biological process	GO:0007015	278	3	18204	50	SORBS1,FMN2,NEBL
4.085e-02	-3.20	acral	COSMIC cancer mutations	acral	268	3	16828	48	CDH20,FMN2,PARD3
4.099e-02	-3.19	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	2	10285	31	SLC4A4,SLC1A2
4.106e-02	-3.19	SCGB1D1 (secretoglobin family 1D member 1)	protein interactions	10648	125	2	19454	50	LRP1B,CPE
4.106e-02	-3.19	UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats)	protein interactions	55075	125	2	19454	50	PARD3,AHCYL1
4.107e-02	-3.19	regulation of synapse assembly	biological process	GO:0051963	117	2	18204	50	NRXN1,NTRK2
4.107e-02	-3.19	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	50	TNIK
4.114e-02	-3.19	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	48	NTRK2,TNIK,DCLK2,PRKG1
4.127e-02	-3.19	human chr3q13.31	chromosome location	human chr3q13.31	22	1	26134	50	LSAMP
4.128e-02	-3.19	EGF_2	prosite domains	PS01186	213	3	12186	44	EFEMP1,NRG3,LRP1B
4.141e-02	-3.18	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	31	ABLIM1
4.141e-02	-3.18	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	31	NRG3
4.159e-02	-3.18	circulatory system development	biological process	GO:0072359	933	6	18204	50	PRKG1,NTRK2,APOE,NEBL,RORA,CPE
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.176e-02	-3.18	Glycerol uptake facilitator protein	gene3d domains	1.20.1080.10	14	1	14470	44	AQP4
4.193e-02	-3.17	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	50	TNIK,MAPK10,CPE,NRG3,NTRK2,PLCB1,NFIA,EFEMP1,CTNND2,SORBS1
4.195e-02	-3.17	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	14	18204	50	RFX4,SORBS1,CLU,APOE,PLCB1,NPAS3,NFIA,SLC4A4,RBMS3,NTRK2,RORA,SPON1,TNIK,GLIS3
4.196e-02	-3.17	ATP binding	molecular function	GO:0005524	1467	8	18094	49	PRKG1,ATP13A4,ATP1A2,MAPK10,DCLK2,ADCY2,NTRK2,TNIK
4.210e-02	-3.17	cellular response to organic substance	biological process	GO:0071310	1716	9	18204	50	AQP4,RYR3,PLCB1,ADCY2,AHCYL1,RORA,SLC1A2,ATP1A2,SORBS1
4.215e-02	-3.17	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	19	RYR3
4.217e-02	-3.17	S_TKc	smart domains	SM00220	348	4	9717	37	DCLK2,TNIK,MAPK10,PRKG1
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	TRPS1,NFIA
4.230e-02	-3.16	EGF-like_Ca-bd_dom	interpro domains	IPR001881	121	2	18521	50	EFEMP1,LRP1B
4.235e-02	-3.16	CarboxyPept-like_regulatory	interpro domains	IPR008969	16	1	18521	50	CPE
4.235e-02	-3.16	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	50	PRKG1
4.248e-02	-3.16	cGMP binding	molecular function	GO:0030553	16	1	18094	49	PRKG1
4.248e-02	-3.16	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	49	ADCY2
4.248e-02	-3.16	oxysterol binding	molecular function	GO:0008142	16	1	18094	49	RORA
4.248e-02	-3.16	misfolded protein binding	molecular function	GO:0051787	16	1	18094	49	CLU
4.248e-02	-3.16	MAP kinase activity	molecular function	GO:0004707	16	1	18094	49	MAPK10
4.248e-02	-3.16	lamin binding	molecular function	GO:0005521	16	1	18094	49	PLCB1
4.248e-02	-3.16	MAP kinase kinase activity	molecular function	GO:0004708	16	1	18094	49	MAPK10
4.248e-02	-3.16	water channel activity	molecular function	GO:0015250	16	1	18094	49	AQP4
4.250e-02	-3.16	MAPK	prosite domains	PS01351	12	1	12186	44	MAPK10
4.250e-02	-3.16	CNMP_BINDING_2	prosite domains	PS00889	12	1	12186	44	PRKG1
4.265e-02	-3.15	Wnt signaling pathway	biological process	GO:0016055	283	3	18204	50	TNIK,CPE,CTNND2
4.282e-02	-3.15	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	48	NTRK2,TNIK,DCLK2,PRKG1
4.282e-02	-3.15	ZNF358 (zinc finger protein 358)	protein interactions	140467	17	1	19454	50	EFEMP1
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	50	APOE
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.286e-02	-3.15	SYT2 (synaptotagmin 2)	protein interactions	127833	128	2	19454	50	AHCYL1,NRXN1
4.286e-02	-3.15	MYB (MYB proto-oncogene, transcription factor)	protein interactions	4602	128	2	19454	50	TRPS1,NFIA
4.296e-02	-3.15	phospholipid binding	molecular function	GO:0005543	489	4	18094	49	APOE,PLCB1,PARD3,PITPNC1
4.299e-02	-3.15	regulation of nervous system process	biological process	GO:0031644	120	2	18204	50	NRXN1,PARD3
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	50	APOE
4.307e-02	-3.14	cardiac left ventricle morphogenesis	biological process	GO:0003214	16	1	18204	50	CPE
4.307e-02	-3.14	response to ether	biological process	GO:0045472	16	1	18204	50	PLCB1
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	S-adenosylmethionine metabolic process	biological process	GO:0046500	16	1	18204	50	AHCYL1
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.307e-02	-3.14	angiotensin-activated signaling pathway	biological process	GO:0038166	16	1	18204	50	AHCYL1
4.307e-02	-3.14	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	50	APOE
4.307e-02	-3.14	neuron cell-cell adhesion	biological process	GO:0007158	16	1	18204	50	NRXN1
4.307e-02	-3.14	insulin metabolic process	biological process	GO:1901142	16	1	18204	50	CPE
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.313e-02	-3.14	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	5	ATP1A2
4.313e-02	-3.14	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	5	ATP1A2
4.318e-02	-3.14	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	23	SLC4A4
4.346e-02	-3.14	Progesterone-mediated oocyte maturation	KEGG pathways	ko04914	92	2	7161	26	ADCY2,MAPK10
4.346e-02	-3.14	Progesterone-mediated oocyte maturation	KEGG pathways	hsa04914	92	2	7161	26	MAPK10,ADCY2
4.358e-02	-3.13	apical dendrite	cellular component	GO:0097440	17	1	19108	50	CLU
4.379e-02	-3.13	regulation of transmembrane transport	biological process	GO:0034762	485	4	18204	50	SLC1A2,AHCYL1,SORBS1,ATP1A2
4.426e-02	-3.12	neuron projection terminus	cellular component	GO:0044306	128	2	19108	50	NTRK2,SLC1A2
4.430e-02	-3.12	N-Glycan antennae elongation	REACTOME pathways	R-HSA-975577	15	1	10285	31	MGAT4C
4.430e-02	-3.12	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	31	NRG3
4.430e-02	-3.12	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	31	ADCY2
4.430e-02	-3.12	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	31	ADCY2
4.453e-02	-3.11	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	45	16828	48	NRXN1,GLIS3,SORBS1,LRP1B,RORA,FMN2,TRPS1,SOX5,TRPM3,HPSE2,NTRK2,PITPNC1,ABLIM1,NFIA,PRKG1,TNIK,NRG3,DTNA,ADCY2,RFX4,DCLK2,SPARCL1,NKAIN3,SLC1A2,MGAT4C,RYR3,GPM6A,SLC4A4,EFEMP1,CLU,AHCYL1,PARD3,PTPRZ1,CPE,LSAMP,GPC5,ATP1A2,NEBL,CDH20,ATP13A4,NPAS3,CTNND2,AQP4,PLCB1,SPON1
4.467e-02	-3.11	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	44	FMN2
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	SOX5,NFIA
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	SOX5,NFIA
4.468e-02	-3.11	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	50	RORA,NFIA
4.475e-02	-3.11	positive regulation of macromolecule biosynthetic process	biological process	GO:0010557	2592	12	18204	50	NTRK2,RORA,SPON1,GLIS3,RFX4,CLU,SORBS1,NPAS3,PLCB1,APOE,NFIA,RBMS3
4.477e-02	-3.11	DWA	smart domains	SM00523	12	1	9717	37	NFIA
4.477e-02	-3.11	ZnF_GATA	smart domains	SM00401	12	1	9717	37	TRPS1
4.492e-02	-3.10	muscle cell differentiation	biological process	GO:0042692	289	3	18204	50	PRKG1,NEBL,RORA
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	1	18521	50	PLCB1
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY2
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.507e-02	-3.10	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	49	PTPRZ1
4.507e-02	-3.10	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	49	PTPRZ1
4.529e-02	-3.09	ZNF224 (zinc finger protein 224)	protein interactions	7767	18	1	19454	50	LRP1B
4.529e-02	-3.09	SOX30 (SRY-box transcription factor 30)	protein interactions	11063	18	1	19454	50	AHCYL1
4.529e-02	-3.09	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	50	APOE
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	PARD3
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKG1
4.551e-02	-3.09	Z disc	cellular component	GO:0030018	130	2	19108	50	RYR3,NEBL
4.553e-02	-3.09	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	3	16828	48	LRP1B,TNIK,ATP1A2
4.558e-02	-3.09	cellular process	biological process	GO:0009987	14996	46	18204	50	NTRK2,NRXN1,SPARCL1,CPE,NFIA,SOX5,CLU,FMN2,SLC4A4,GPM6A,NRG3,CTNNA2,GLIS3,LRP1B,RYR3,APOE,ADCY2,SLC1A2,PTPRZ1,RFX4,PARD3,HPSE2,CDH20,MAPK10,GPC5,NEBL,CTNND2,DTNA,PRKG1,ATP1A2,TNIK,SPON1,PLCB1,TRPM3,EFEMP1,MGAT4C,MSI2,AQP4,AHCYL1,RORA,PITPNC1,ATP13A4,DCLK2,ABLIM1,SORBS1,LSAMP
4.560e-02	-3.09	cardiocyte differentiation	biological process	GO:0035051	124	2	18204	50	PRKG1,NEBL
4.560e-02	-3.09	action potential	biological process	GO:0001508	124	2	18204	50	ATP1A2,NTRK2
4.560e-02	-3.09	positive regulation of lipid metabolic process	biological process	GO:0045834	124	2	18204	50	SORBS1,APOE
4.570e-02	-3.09	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	50	APOE
4.570e-02	-3.09	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	50	CTNNA2
4.570e-02	-3.09	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	50	APOE
4.570e-02	-3.09	viral genome replication	biological process	GO:0019079	17	1	18204	50	NFIA
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	50	NTRK2
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	regulation of fertilization	biological process	GO:0080154	17	1	18204	50	PLCB1
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	TNIK
4.570e-02	-3.09	positive regulation of meiotic nuclear division	biological process	GO:0045836	17	1	18204	50	PLCB1
4.570e-02	-3.09	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	50	ATP1A2
4.570e-02	-3.09	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	50	RORA
4.570e-02	-3.09	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	50	SORBS1
4.570e-02	-3.09	ureter development	biological process	GO:0072189	17	1	18204	50	NFIA
4.570e-02	-3.09	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	50	APOE
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	cGMP metabolic process	biological process	GO:0046068	17	1	18204	50	RORA
4.570e-02	-3.09	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	50	CLU
4.570e-02	-3.09	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	50	APOE
4.579e-02	-3.08	signaling receptor binding	molecular function	GO:0005102	1493	8	18094	49	NRG3,SORBS1,APOE,PTPRZ1,NRXN1,CLU,EFEMP1,CPE
4.581e-02	-3.08	ZZ	pfam domains	PF00569	17	1	17795	49	DTNA
4.581e-02	-3.08	PI-PLC-X	pfam domains	PF00388	17	1	17795	49	PLCB1
4.581e-02	-3.08	Carb_anhydrase	pfam domains	PF00194	17	1	17795	49	PTPRZ1
4.596e-02	-3.08	CARBOXYPEPT_ZN_2	prosite domains	PS00133	13	1	12186	44	CPE
4.596e-02	-3.08	CARBOXYPEPT_ZN_1	prosite domains	PS00132	13	1	12186	44	CPE
4.596e-02	-3.08	LDLRB	prosite domains	PS51120	13	1	12186	44	LRP1B
4.598e-02	-3.08	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	48	CTNND2,FMN2
4.605e-02	-3.08	Endocrine resistance	KEGG pathways	ko01522	95	2	7161	26	ADCY2,MAPK10
4.605e-02	-3.08	Endocrine resistance	KEGG pathways	hsa01522	95	2	7161	26	MAPK10,ADCY2
4.626e-02	-3.07	cerebral cortex development	biological process	GO:0021987	125	2	18204	50	NTRK2,PLCB1
4.626e-02	-3.07	memory	biological process	GO:0007613	125	2	18204	50	APOE,PLCB1
4.626e-02	-3.07	actomyosin structure organization	biological process	GO:0031032	125	2	18204	50	NEBL,SORBS1
4.636e-02	-3.07	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	4	12186	44	NTRK2,PRKG1,TNIK,DCLK2
4.653e-02	-3.07	EGFR (epidermal growth factor receptor)	protein interactions	1956	3105	13	19454	50	NTRK2,TNIK,SPARCL1,CTNND2,CLU,AHCYL1,ABLIM1,TRPS1,DTNA,PARD3,TRPM3,CTNNA2,SORBS1
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	CPE,GPM6A
4.654e-02	-3.07	channel activity	molecular function	GO:0015267	502	4	18094	49	AQP4,TRPM3,RYR3,GPM6A
4.665e-02	-3.07	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	5	ATP1A2
4.665e-02	-3.07	Succinate Signalling During Inflammation	SMPDB pathways	SMP0084634	13	1	1369	5	PLCB1
4.667e-02	-3.06	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	48	DTNA,CDH20
4.677e-02	-3.06	human chr20p12.3	chromosome location	human chr20p12.3	25	1	26134	50	PLCB1
4.682e-02	-3.06	passive transmembrane transporter activity	molecular function	GO:0022803	503	4	18094	49	AQP4,RYR3,TRPM3,GPM6A
4.691e-02	-3.06	EGF_CA	prosite domains	PS01187	96	2	12186	44	LRP1B,EFEMP1
4.693e-02	-3.06	limbic system development	biological process	GO:0021761	126	2	18204	50	DCLK2,ATP1A2
4.716e-02	-3.05	FOXP1 (forkhead box P1)	protein interactions	27086	135	2	19454	50	NFIA,SOX5
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	TRPS1,ABLIM1
4.716e-02	-3.05	SOX15 (SRY-box transcription factor 15)	protein interactions	6665	135	2	19454	50	NFIA,TRPS1
4.718e-02	-3.05	PKA activation	REACTOME pathways	R-HSA-163615	16	1	10285	31	ADCY2
4.718e-02	-3.05	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	1	10285	31	NRG3
4.718e-02	-3.05	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	31	NRG3
4.718e-02	-3.05	Rap1 signalling	REACTOME pathways	R-HSA-392517	16	1	10285	31	PRKG1
4.746e-02	-3.05	regulation of anatomical structure size	biological process	GO:0090066	498	4	18204	50	PRKG1,ATP1A2,AQP4,APOE
4.746e-02	-3.05	Growth_fac_rcpt_cys_sf	interpro domains	IPR009030	129	2	18521	50	LRP1B,EFEMP1
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY2
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY2
4.760e-02	-3.05	response to amino acid	biological process	GO:0043200	127	2	18204	50	SLC1A2,NTRK2
4.760e-02	-3.05	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	50	CDH20,PARD3
4.764e-02	-3.04	positive regulation of nervous system development	biological process	GO:0051962	296	3	18204	50	PTPRZ1,NTRK2,NRXN1
4.766e-02	-3.04	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	1	18094	49	SLC1A2
4.766e-02	-3.04	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	49	PITPNC1
4.766e-02	-3.04	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	49	NRG3
4.766e-02	-3.04	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	49	RYR3
4.766e-02	-3.04	lipoprotein particle receptor activity	molecular function	GO:0030228	18	1	18094	49	LRP1B
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	EGFL6 (EGF like domain multiple 6)	protein interactions	25975	19	1	19454	50	LRP1B
4.774e-02	-3.04	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	50	NRXN1
4.774e-02	-3.04	ZNF627 (zinc finger protein 627)	protein interactions	199692	19	1	19454	50	EFEMP1
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	ZNF791 (zinc finger protein 791)	protein interactions	163049	19	1	19454	50	EFEMP1
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	Trp53 (transformation related protein 53)	protein interactions	22059	19	1	19454	50	MAPK10
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	PLCB2 (phospholipase C beta 2)	protein interactions	5330	19	1	19454	50	PLCB1
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	NLGN1 (neuroligin 1)	protein interactions	22871	19	1	19454	50	NRXN1
4.782e-02	-3.04	regulation of multicellular organismal development	biological process	GO:2000026	1484	8	18204	50	TRPS1,EFEMP1,PTPRZ1,PARD3,SOX5,NRXN1,NTRK2,PLCB1
4.802e-02	-3.04	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	48	16828	48	ATP13A4,NPAS3,AQP4,CTNND2,PLCB1,SPON1,ATP1A2,MSI2,NEBL,APOE,RBMS3,CDH20,LSAMP,CPE,GPC5,CLU,AHCYL1,PTPRZ1,PARD3,RFX4,DCLK2,SPARCL1,NKAIN3,SLC4A4,GPM6A,EFEMP1,MGAT4C,SLC1A2,RYR3,NFIA,PRKG1,NRG3,TNIK,DTNA,ADCY2,TRPM3,SOX5,HPSE2,NTRK2,PITPNC1,ABLIM1,SORBS1,NRXN1,GLIS3,LRP1B,TRPS1,FMN2,RORA
4.804e-02	-3.04	carboxylic acid transport	biological process	GO:0046942	297	3	18204	50	SLC1A2,NTRK2,APOE
4.822e-02	-3.03	cell population proliferation	biological process	GO:0008283	726	5	18204	50	HPSE2,NFIA,RORA,SOX5,CLU
4.828e-02	-3.03	seminoma	COSMIC cancer mutations	seminoma	700	5	16828	48	NTRK2,TRPS1,TNIK,DCLK2,PRKG1
4.832e-02	-3.03	positive regulation of myelination	biological process	GO:0031643	18	1	18204	50	PARD3
4.832e-02	-3.03	regulation of establishment of endothelial barrier	biological process	GO:1903140	18	1	18204	50	PLCB1
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	50	NEBL
4.832e-02	-3.03	myelin maintenance	biological process	GO:0043217	18	1	18204	50	CLU
4.832e-02	-3.03	regulation of endothelial cell development	biological process	GO:1901550	18	1	18204	50	PLCB1
4.832e-02	-3.03	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	50	NTRK2
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.832e-02	-3.03	regulation of acrosome reaction	biological process	GO:0060046	18	1	18204	50	PLCB1
4.832e-02	-3.03	response to misfolded protein	biological process	GO:0051788	18	1	18204	50	CLU
4.842e-02	-3.03	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	2	19454	50	SOX5,NFIA
4.843e-02	-3.03	organic acid transport	biological process	GO:0015849	298	3	18204	50	APOE,NTRK2,SLC1A2
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY2
4.859e-02	-3.02	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	50	ATP1A2
4.859e-02	-3.02	cytosolic region	cellular component	GO:0099522	19	1	19108	50	PLCB1
4.859e-02	-3.02	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	50	GPM6A
4.859e-02	-3.02	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	50	TNIK
4.859e-02	-3.02	human chr2p16.1	chromosome location	human chr2p16.1	26	1	26134	50	EFEMP1
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.870e-02	-3.02	Estrogen signaling pathway	KEGG pathways	ko04915	98	2	7161	26	PLCB1,ADCY2
4.870e-02	-3.02	Estrogen signaling pathway	KEGG pathways	hsa04915	98	2	7161	26	PLCB1,ADCY2
4.875e-02	-3.02	chondrosarcoma	COSMIC cancer mutations	chondrosarcoma	1181	7	16828	48	CPE,LSAMP,LRP1B,ADCY2,SPON1,SLC4A4,HPSE2
4.900e-02	-3.02	ERK Pathway in Huntington's Disease	WikiPathways	WP3853	14	1	5310	19	NTRK2
4.921e-02	-3.01	cellular response to hormone stimulus	biological process	GO:0032870	504	4	18204	50	AHCYL1,PLCB1,ATP1A2,SORBS1
4.945e-02	-3.01	Ig_I-set	interpro domains	IPR013098	132	2	18521	50	LSAMP,NTRK2
4.951e-02	-3.01	response to inorganic substance	biological process	GO:0010035	505	4	18204	50	PLCB1,AHCYL1,RYR3,ATP1A2
4.959e-02	-3.00	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	ko04933	99	2	7161	26	MAPK10,PLCB1
4.959e-02	-3.00	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	hsa04933	99	2	7161	26	PLCB1,MAPK10
4.961e-02	-3.00	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	4	16828	48	TNIK,NTRK2,DCLK2,PRKG1
4.963e-02	-3.00	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	3	16828	48	SLC1A2,NRG3,PRKG1
4.963e-02	-3.00	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	3	16828	48	SLC1A2,NRG3,PRKG1
4.968e-02	-3.00	NEFM (neurofilament medium chain)	protein interactions	4741	139	2	19454	50	TNIK,APOE
4.968e-02	-3.00	SPCS2 (signal peptidase complex subunit 2)	protein interactions	9789	139	2	19454	50	GPC5,MGAT4C