TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols WP3679 Cell-type Dependent Selectivity of CCK2R Signaling 0.000924291517011288 -6.98648304147958 13 2 0.105263157894737 19 5310 23236,6263 PLCB1,RYR3 WP2059 Alzheimers Disease 0.0148163689793228 -4.21202269727645 148 3 0.157894736842105 19 5310 348,23236,6263 APOE,PLCB1,RYR3 WP706 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 0.0188595633144272 -3.97073515610495 162 3 0.157894736842105 19 5310 6095,4915,361 RORA,NTRK2,AQP4 WP2032 Human Thyroid Stimulating Hormone (TSH) signaling pathway 0.024014260874359 -3.72910742200466 68 2 0.105263157894737 19 5310 108,23236 ADCY2,PLCB1 WP3601 Composition of Lipid Particles 0.0352402592550023 -3.34556612110233 10 1 0.0526315789473684 19 5310 348 APOE WP3301 MFAP5-mediated ovarian cancer cell motility and invasiveness 0.0421456562537418 -3.166623654323 12 1 0.0526315789473684 19 5310 6263 RYR3 WP3853 ERK Pathway in Huntington's Disease 0.0490042106783381 -3.01584905235249 14 1 0.0526315789473684 19 5310 4915 NTRK2 WP185 Integrin-mediated Cell Adhesion 0.0514284111974296 -2.96756451219768 103 2 0.105263157894737 19 5310 5602,10580 MAPK10,SORBS1 WP384 Apoptosis Modulation by HSP70 0.065947626187307 -2.71889439459388 19 1 0.0526315789473684 19 5310 5602 MAPK10 WP2431 Spinal Cord Injury 0.0664612325795261 -2.7111364700416 119 2 0.105263157894737 19 5310 5803,361 PTPRZ1,AQP4 WP1602 Nicotine Activity on Dopaminergic Neurons 0.0726445839378167 -2.6221764418093 21 1 0.0526315789473684 19 5310 108 ADCY2 WP26 Signal Transduction of S1P Receptor 0.0891885290037721 -2.4170028462781 26 1 0.0526315789473684 19 5310 23236 PLCB1 WP2858 Ectoderm Differentiation 0.0913891039475786 -2.39262902045581 143 2 0.105263157894737 19 5310 1496,1501 CTNNA2,CTNND2 WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 0.0924824249247066 -2.38073665333018 144 2 0.105263157894737 19 5310 4915,5602 NTRK2,MAPK10 WP422 MAPK Cascade 0.0989802695203817 -2.31283474648391 29 1 0.0526315789473684 19 5310 5602 MAPK10 WP2643 Nanoparticle-mediated activation of receptor signaling 0.0989802695203817 -2.31283474648391 29 1 0.0526315789473684 19 5310 5602 MAPK10 WP536 Calcium Regulation in the Cardiac Cell 0.100246133500886 -2.30012678210896 151 2 0.105263157894737 19 5310 6263,108 RYR3,ADCY2 WP408 Oxidative Stress 0.105452602080923 -2.24949369639288 31 1 0.0526315789473684 19 5310 5602 MAPK10 WP289 Myometrial Relaxation and Contraction Pathways 0.108193809723125 -2.22383112563777 158 2 0.105263157894737 19 5310 6263,108 RYR3,ADCY2 WP2525 Trans-sulfuration and one carbon metabolism 0.108672227116414 -2.21941901780972 32 1 0.0526315789473684 19 5310 10768 AHCYL1 WP3893 Development and heterogeneity of the ILC family 0.108672227116414 -2.21941901780972 32 1 0.0526315789473684 19 5310 6095 RORA WP481 Insulin Signaling 0.111653107572109 -2.19235846792514 161 2 0.105263157894737 19 5310 5602,10580 MAPK10,SORBS1 WP3676 BDNF-TrkB Signaling 0.111880871997615 -2.190320616635 33 1 0.0526315789473684 19 5310 4915 NTRK2 WP430 Statin Pathway 0.111880871997615 -2.190320616635 33 1 0.0526315789473684 19 5310 348 APOE WP2197 Endothelin Pathways 0.111880871997615 -2.190320616635 33 1 0.0526315789473684 19 5310 23236 PLCB1 WP3298 Melatonin metabolism and effects 0.121441278912442 -2.10832443416133 36 1 0.0526315789473684 19 5310 348 APOE WP2447 Amyotrophic lateral sclerosis (ALS) 0.127760628402205 -2.05759685647285 38 1 0.0526315789473684 19 5310 6506 SLC1A2 WP170 Nuclear Receptors 0.130904131451801 -2.0332900446713 39 1 0.0526315789473684 19 5310 6095 RORA WP524 G13 Signaling Pathway 0.134036899711373 -2.00964014595846 40 1 0.0526315789473684 19 5310 5602 MAPK10 WP2637 Structural Pathway of Interleukin 1 (IL-1) 0.164781735529747 -1.80313349574485 50 1 0.0526315789473684 19 5310 5602 MAPK10 WP3594 Circadian rythm related genes 0.167967098645612 -1.78398716015347 207 2 0.105263157894737 19 5310 6095,5602 RORA,MAPK10 WP2267 Synaptic Vesicle Pathway 0.170805305618976 -1.76723093476717 52 1 0.0526315789473684 19 5310 477 ATP1A2 WP1533 Vitamin B12 Metabolism 0.173801634869341 -1.74984065958208 53 1 0.0526315789473684 19 5310 348 APOE WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer 0.176787704668404 -1.73280567492762 54 1 0.0526315789473684 19 5310 348 APOE WP673 ErbB Signaling Pathway 0.176787704668404 -1.73280567492762 54 1 0.0526315789473684 19 5310 10718 NRG3 WP2795 Cardiac Hypertrophic Response 0.185684688695179 -1.68370526585276 57 1 0.0526315789473684 19 5310 5592 PRKG1 WP558 Complement and Coagulation Cascades 0.194490526223849 -1.6373718254706 60 1 0.0526315789473684 19 5310 1191 CLU WP3865 RIG-I-like Receptor Signaling 0.197405703368241 -1.62249425995717 61 1 0.0526315789473684 19 5310 5602 MAPK10 WP474 Endochondral Ossification 0.208966767304882 -1.56558004777107 65 1 0.0526315789473684 19 5310 6660 SOX5 WP1403 AMP-activated Protein Kinase (AMPK) Signaling 0.217533839598151 -1.52540085619607 68 1 0.0526315789473684 19 5310 23236 PLCB1 WP428 Wnt Signaling Pathway 0.223196307062943 -1.49970359402878 70 1 0.0526315789473684 19 5310 5602 MAPK10 WP2118 Arrhythmogenic Right Ventricular Cardiomyopathy 0.239951700791813 -1.42731762259376 76 1 0.0526315789473684 19 5310 1496 CTNNA2 WP254 Apoptosis 0.267118910569772 -1.32006136178508 86 1 0.0526315789473684 19 5310 5602 MAPK10 WP35 G Protein Signaling Pathways 0.29078049813434 -1.23518659838334 95 1 0.0526315789473684 19 5310 108 ADCY2 WP1544 MicroRNAs in cardiomyocyte hypertrophy 0.308681663239904 -1.17544474917379 102 1 0.0526315789473684 19 5310 5592 PRKG1 WP2064 Neural Crest Differentiation 0.308681663239904 -1.17544474917379 102 1 0.0526315789473684 19 5310 6660 SOX5 WP75 Toll-like Receptor Signaling Pathway 0.311203753947241 -1.16730742393819 103 1 0.0526315789473684 19 5310 5602 MAPK10 WP399 Wnt Signaling Pathway and Pluripotency 0.318717828395548 -1.1434491181271 106 1 0.0526315789473684 19 5310 5602 MAPK10 WP710 DNA Damage Response (only ATM dependent) 0.338377545923527 -1.08359300710545 114 1 0.0526315789473684 19 5310 5602 MAPK10 WP236 Adipogenesis 0.378384532398049 -0.971844318966382 131 1 0.0526315789473684 19 5310 6095 RORA WP3915 Angiopoietin Like Protein 8 Regulatory Pathway 0.38066502938348 -0.965835478537726 132 1 0.0526315789473684 19 5310 5602 MAPK10 WP1449 Regulation of toll-like receptor signaling pathway 0.409599477154327 -0.892575481736348 145 1 0.0526315789473684 19 5310 5602 MAPK10 WP382 MAPK Signaling Pathway 0.461681008790784 -0.772881083538527 170 1 0.0526315789473684 19 5310 5602 MAPK10 WP176 Folate Metabolism 0.999999999984461 -1.55388002200899e-11 69 0 0 19 5310 WP2369 Histone Modifications 0.999999999984461 -1.55388002200899e-11 69 0 0 19 5310 WP707 DNA Damage Response 0.999999999984461 -1.55388002200899e-11 69 0 0 19 5310 WP2359 Parkin-Ubiquitin Proteasomal System pathway 0.999999999985344 -1.46557680209654e-11 70 0 0 19 5310 WP3892 Development of pulmonary dendritic cells and macrophage subsets 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP1434 Osteopontin Signaling 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP3871 Valproic acid pathway 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP1991 SRF and miRs in Smooth Muscle Differentiation and Proliferation 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP186 Homologous recombination 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP1423 Ganglio Sphingolipid Metabolism 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP3876 BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP2881 Estrogen Receptor Pathway 0.999999999986881 -1.31194286338476e-11 13 0 0 19 5310 WP304 Kit receptor signaling pathway 0.999999999989966 -1.00343772595347e-11 60 0 0 19 5310 WP3527 Preimplantation Embryo 0.999999999989966 -1.00343772595347e-11 60 0 0 19 5310 WP1422 Sphingolipid Metabolism 0.99999999999041 -9.59022802628309e-12 20 0 0 19 5310 WP732 Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 0.99999999999041 -9.59022802628309e-12 20 0 0 19 5310 WP516 Hypertrophy Model 0.99999999999041 -9.59022802628309e-12 20 0 0 19 5310 WP497 Urea cycle and metabolism of amino groups 0.99999999999041 -9.59022802628309e-12 20 0 0 19 5310 WP391 Mitochondrial Gene Expression 0.99999999999041 -9.59022802628309e-12 20 0 0 19 5310 WP1742 TP53 Network 0.99999999999041 -9.59022802628309e-12 20 0 0 19 5310 WP477 Cytoplasmic Ribosomal Proteins 0.99999999999085 -9.14983974620114e-12 90 0 0 19 5310 WP138 Androgen receptor signaling pathway 0.99999999999085 -9.14983974620114e-12 90 0 0 19 5310 WP3845 Canonical and Non-canonical Notch signaling 0.999999999990999 -9.00143742197961e-12 27 0 0 19 5310 WP2035 Follicle Stimulating Hormone (FSH) signaling pathway 0.999999999990999 -9.00143742197961e-12 27 0 0 19 5310 WP262 EBV LMP1 signaling 0.999999999991018 -8.98206363450397e-12 24 0 0 19 5310 WP2509 Nanoparticle triggered autophagic cell death 0.999999999991018 -8.98206363450397e-12 24 0 0 19 5310 WP1539 Angiogenesis 0.999999999991018 -8.98206363450397e-12 24 0 0 19 5310 WP3658 Wnt/beta-catenin Signaling Pathway in Leukemia 0.999999999991018 -8.98206363450397e-12 24 0 0 19 5310 WP334 GPCRs, Class B Secretin-like 0.999999999991018 -8.98206363450397e-12 24 0 0 19 5310 WP560 TGF-beta Receptor Signaling 0.999999999991443 -8.55697115121409e-12 58 0 0 19 5310 WP183 Proteasome Degradation 0.999999999991739 -8.26125894384108e-12 66 0 0 19 5310 WP2324 AGE/RAGE pathway 0.999999999991739 -8.26125894384108e-12 66 0 0 19 5310 WP2374 Oncostatin M Signaling Pathway 0.999999999991739 -8.26125894384108e-12 66 0 0 19 5310 WP3651 Pathways Affected in Adenoid Cystic Carcinoma 0.999999999991739 -8.26125894384108e-12 66 0 0 19 5310 WP195 IL-1 signaling pathway 0.999999999991742 -8.25775686065484e-12 57 0 0 19 5310 WP716 Vitamin A and Carotenoid Metabolism 0.999999999992373 -7.62743962296607e-12 44 0 0 19 5310 WP2332 Interleukin-11 Signaling Pathway 0.999999999992373 -7.62743962296607e-12 44 0 0 19 5310 WP314 Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation 0.999999999992373 -7.62743962296607e-12 44 0 0 19 5310 WP2029 Cell Differentiation - Index 0.999999999992514 -7.48583915856312e-12 38 0 0 19 5310 WP383 Striated Muscle Contraction 0.999999999992514 -7.48583915856312e-12 38 0 0 19 5310 WP2526 PDGF Pathway 0.999999999992514 -7.48583915856312e-12 38 0 0 19 5310 WP2012 miRs in Muscle Cell Differentiation 0.99999999999258 -7.42017443539479e-12 36 0 0 19 5310 WP500 Glycogen Metabolism 0.99999999999258 -7.42017443539479e-12 36 0 0 19 5310 WP585 Interferon type I signaling pathways 0.999999999993377 -6.62347702629972e-12 55 0 0 19 5310 WP2018 RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway 0.999999999993377 -6.62347702629972e-12 55 0 0 19 5310 WP395 IL-4 Signaling Pathway 0.999999999993377 -6.62347702629972e-12 55 0 0 19 5310 WP2272 Pathogenic Escherichia coli infection 0.999999999993377 -6.62347702629972e-12 55 0 0 19 5310 WP2328 Allograft Rejection 0.999999999993511 -6.48884022106211e-12 80 0 0 19 5310 WP231 TNF alpha Signaling Pathway 0.999999999993892 -6.10794887160912e-12 94 0 0 19 5310 WP1772 Apoptosis Modulation and Signaling 0.999999999993892 -6.10794887160912e-12 94 0 0 19 5310 WP897 Androgen receptor signaling pathway 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP690 Polyol Pathway 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP3302 eIF5A regulation in response to inhibition of the nuclear export system 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP3633 Caffeine and Theobromine metabolism 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP1603 Nicotine Activity on Chromaffin Cells 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP1941 Peroxisomal beta-oxidation of tetracosanoyl-CoA 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP1133 Androgen receptor signaling pathway 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP2253 Pilocytic astrocytoma 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP521 Amino acid conjugation of benzoic acid 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP733 Serotonin Receptor 2 and STAT3 Signaling 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP2491 Diclofenac Metabolic Pathway 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP2889 Oxytocin signaling 0.99999999999408 -5.91976003417622e-12 4 0 0 19 5310 WP1584 Type II diabetes mellitus 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP167 Eicosanoid Synthesis 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP545 Complement Activation 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP272 Blood Clotting Cascade 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP100 Glutathione metabolism 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP3599 Transcription factor regulation in adipogenesis 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP3657 Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP3872 Regulation of Apoptosis by Parathyroid Hormone-related Protein 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP3645 NAD+ biosynthetic pathways 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP1424 Globo Sphingolipid Metabolism 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP357 Fatty Acid Biosynthesis 0.999999999994492 -5.50811675073038e-12 22 0 0 19 5310 WP49 IL-2 Signaling Pathway 0.999999999994505 -5.49491807655689e-12 42 0 0 19 5310 WP466 DNA Replication 0.999999999994505 -5.49491807655689e-12 42 0 0 19 5310 WP405 Eukaryotic Transcription Initiation 0.999999999994505 -5.49491807655689e-12 42 0 0 19 5310 WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway 0.999999999994505 -5.49491807655689e-12 42 0 0 19 5310 WP2636 Common Pathways Underlying Drug Addiction 0.999999999994505 -5.49491807655689e-12 42 0 0 19 5310 WP136 Phase I biotransformations, non P450 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP3407 FTO Obesity Variant Mechanism 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP1604 Codeine and Morphine Metabolism 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP3634 Insulin signalling in human adipocytes (normal condition) 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP3635 Insulin signalling in human adipocytes (diabetic condition) 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP2338 miRNA Biogenesis 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP3655 Hypothetical Craniofacial Development Pathway 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP2276 Glial Cell Differentiation 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP2485 NAD Biosynthesis II (from tryptophan) 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP237 Glucocorticoid & Mineralcorticoid Metabolism 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP1589 Folate-Alcohol and Cancer Pathway 0.99999999999451 -5.48994501014485e-12 8 0 0 19 5310 WP3859 TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition 0.999999999994869 -5.13141897608986e-12 18 0 0 19 5310 WP3413 NOTCH1 regulation of human endothelial cell calcification 0.999999999994869 -5.13141897608986e-12 18 0 0 19 5310 WP692 Sulfation Biotransformation Reaction 0.999999999994869 -5.13141897608986e-12 18 0 0 19 5310 WP3879 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression 0.999999999994869 -5.13141897608986e-12 18 0 0 19 5310 WP3664 Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds 0.999999999994869 -5.13141897608986e-12 18 0 0 19 5310 WP2203 Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 0.999999999995402 -4.59846327616055e-12 47 0 0 19 5310 WP2911 miRNA targets in ECM and membrane receptors 0.99999999999561 -4.38994703723183e-12 43 0 0 19 5310 WP364 IL-6 signaling pathway 0.99999999999561 -4.38994703723183e-12 43 0 0 19 5310 WP2878 PPAR Alpha Pathway 0.999999999995795 -4.20515059396473e-12 26 0 0 19 5310 WP698 Glucuronidation 0.999999999995795 -4.20515059396473e-12 26 0 0 19 5310 WP581 EPO Receptor Signaling 0.999999999995795 -4.20515059396473e-12 26 0 0 19 5310 WP530 Cytokines and Inflammatory Response 0.999999999995795 -4.20515059396473e-12 26 0 0 19 5310 WP325 Triacylglyceride Synthesis 0.999999999995795 -4.20515059396473e-12 26 0 0 19 5310 WP3844 PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 0.99999999999582 -4.17968836227123e-12 30 0 0 19 5310 WP3851 TLR4 Signaling and Tolerance 0.99999999999582 -4.17968836227123e-12 30 0 0 19 5310 WP241 One Carbon Metabolism 0.99999999999582 -4.17968836227123e-12 30 0 0 19 5310 WP129 Matrix Metalloproteinases 0.99999999999582 -4.17968836227123e-12 30 0 0 19 5310 WP2870 Extracellular vesicle-mediated signaling in recipient cells 0.99999999999582 -4.17968836227123e-12 30 0 0 19 5310 WP2855 Dopaminergic Neurogenesis 0.99999999999582 -4.17968836227123e-12 30 0 0 19 5310 WP98 Prostaglandin Synthesis and Regulation 0.99999999999582 -4.17968836227123e-12 30 0 0 19 5310 WP2846 Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation 0.999999999996222 -3.77756327644964e-12 3 0 0 19 5310 WP3408 Evolocumab Mechanism 0.999999999996222 -3.77756327644964e-12 3 0 0 19 5310 WP3875 ATR Signaling 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP531 Mismatch repair 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP3297 EV release from cardiac cells and their functional effects 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP561 Heme Biosynthesis 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP3593 miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP696 Benzo(a)pyrene metabolism 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP288 NLR Proteins 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP2942 DDX1 as a regulatory component of the Drosha microprocessor 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP3674 Tgif disruption of Shh signaling 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP3585 Cytosine methylation 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP3300 Dual hijack model of Vif in HIV infection 0.999999999996254 -3.74638604766843e-12 9 0 0 19 5310 WP411 mRNA Processing 0.99999999999644 -3.56050926357012e-12 132 0 0 19 5310 WP2371 Parkinsons Disease Pathway 0.999999999996858 -3.14187924074933e-12 83 0 0 19 5310 WP2261 Signaling Pathways in Glioblastoma 0.999999999996858 -3.14187924074933e-12 83 0 0 19 5310 WP299 Nuclear Receptors in Lipid Metabolism and Toxicity 0.999999999996928 -3.07163824528717e-12 35 0 0 19 5310 WP3617 Photodynamic therapy-induced NF-kB survival signaling 0.999999999996928 -3.07163824528717e-12 35 0 0 19 5310 WP244 Alpha 6 Beta 4 signaling pathway 0.999999999996928 -3.07163824528717e-12 35 0 0 19 5310 WP2366 Butyrate-induced histone acetylation 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP1311 Folic Acid Network 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP2943 Hypoxia-mediated EMT and Stemness 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP2646 Lidocaine metabolism 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP2816 Felbamate Metabolism 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP2901 Gonadotropin-releasing hormone (GnRH) signaling 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP1273 Folic Acid Network 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP1438 Influenza A virus infection 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP2866 mir34a and TGIF2 in osteoclastogenesis 0.999999999997233 -2.76749757889571e-12 2 0 0 19 5310 WP3613 Photodynamic therapy-induced unfolded protein response 0.999999999997289 -2.71066433808412e-12 29 0 0 19 5310 WP2583 T-Cell Receptor and Co-stimulatory Signaling 0.999999999997289 -2.71066433808412e-12 29 0 0 19 5310 WP2361 Gastric Cancer Network 1 0.99999999999729 -2.70985998026994e-12 28 0 0 19 5310 WP2249 Metastatic brain tumor 0.99999999999729 -2.70985998026994e-12 28 0 0 19 5310 WP2884 NRF2 pathway 0.999999999997329 -2.67099465562932e-12 143 0 0 19 5310 WP2333 Trans-sulfuration pathway 0.999999999997337 -2.66282645512685e-12 10 0 0 19 5310 WP1531 Vitamin D Metabolism 0.999999999997337 -2.66282645512685e-12 10 0 0 19 5310 WP2874 Liver X Receptor Pathway 0.999999999997337 -2.66282645512685e-12 10 0 0 19 5310 WP2113 Type III interferon signaling 0.999999999997337 -2.66282645512685e-12 10 0 0 19 5310 WP496 Steroid Biosynthesis 0.999999999997337 -2.66282645512685e-12 10 0 0 19 5310 WP3656 Interleukin-1 Induced Activation of NF-kappa-B 0.999999999997337 -2.66282645512685e-12 10 0 0 19 5310 WP704 Methylation Pathways 0.999999999997337 -2.66282645512685e-12 10 0 0 19 5310 WP2875 Constitutive Androstane Receptor Pathway 0.99999999999738 -2.62033845506943e-12 32 0 0 19 5310 WP34 Ovarian Infertility Genes 0.99999999999738 -2.62033845506943e-12 32 0 0 19 5310 WP3858 Toll-like Receptor Signaling 0.99999999999738 -2.62033845506943e-12 32 0 0 19 5310 WP727 Monoamine Transport 0.99999999999738 -2.62033845506943e-12 32 0 0 19 5310 WP2828 Bladder Cancer 0.99999999999738 -2.62033845506943e-12 32 0 0 19 5310 WP455 GPCRs, Class A Rhodopsin-like 0.99999999999739 -2.6099670944399e-12 259 0 0 19 5310 WP1600 Nicotine Metabolism 0.999999999997441 -2.55885266227293e-12 6 0 0 19 5310 WP694 Arylamine metabolism 0.999999999997441 -2.55885266227293e-12 6 0 0 19 5310 WP3891 Benzene metabolism 0.999999999997441 -2.55885266227293e-12 6 0 0 19 5310 WP1981 Thyroxine (Thyroid Hormone) Production 0.999999999997441 -2.55885266227293e-12 6 0 0 19 5310 WP2516 ATM Signaling Pathway 0.999999999997592 -2.40802249320745e-12 40 0 0 19 5310 WP127 IL-5 Signaling Pathway 0.999999999997592 -2.40802249320745e-12 40 0 0 19 5310 WP45 G1 to S cell cycle control 0.999999999997753 -2.24706853530023e-12 68 0 0 19 5310 WP3680 Association Between Physico-Chemical Features and Toxicity Associated Pathways 0.999999999997753 -2.24706853530023e-12 68 0 0 19 5310 WP3303 Rac1/Pak1/p38/MMP-2 pathway 0.999999999997753 -2.24706853530023e-12 68 0 0 19 5310 WP111 Electron Transport Chain 0.999999999997777 -2.22329626268452e-12 92 0 0 19 5310 WP3925 Amino Acid metabolism 0.999999999997905 -2.0949995274228e-12 91 0 0 19 5310 WP69 T-Cell antigen Receptor (TCR) Signaling Pathway 0.999999999997905 -2.0949995274228e-12 91 0 0 19 5310 WP2873 Aryl Hydrocarbon Receptor Pathway 0.999999999997908 -2.09243536871697e-12 48 0 0 19 5310 WP2586 Aryl Hydrocarbon Receptor 0.999999999997908 -2.09243536871697e-12 48 0 0 19 5310 WP2848 Differentiation Pathway 0.999999999997908 -2.09243536871697e-12 48 0 0 19 5310 WP2849 Hematopoietic Stem Cell Differentiation 0.999999999997908 -2.09243536871697e-12 48 0 0 19 5310 WP3878 ATM Signaling Network in Development and Disease 0.999999999997963 -2.03717180352305e-12 46 0 0 19 5310 WP1971 Integrated Cancer Pathway 0.999999999997963 -2.03717180352305e-12 46 0 0 19 5310 WP1591 Heart Development 0.999999999997963 -2.03717180352305e-12 46 0 0 19 5310 WP465 Tryptophan metabolism 0.999999999997963 -2.03717180352305e-12 46 0 0 19 5310 WP28 Selenium Metabolism and Selenoproteins 0.999999999997963 -2.03717180352305e-12 46 0 0 19 5310 WP268 Notch Signaling Pathway 0.999999999997963 -2.03717180352305e-12 46 0 0 19 5310 WP2857 Mesodermal Commitment Pathway 0.999999999998022 -1.9782034714859e-12 155 0 0 19 5310 WP322 Osteoblast Signaling 0.999999999998108 -1.89212693948101e-12 14 0 0 19 5310 WP229 Irinotecan Pathway 0.999999999998108 -1.89212693948101e-12 14 0 0 19 5310 WP2436 Dopamine metabolism 0.999999999998108 -1.89212693948101e-12 14 0 0 19 5310 WP1559 TFs Regulate miRNAs related to cardiac hypertrophy 0.999999999998129 -1.87124611415313e-12 12 0 0 19 5310 WP3672 LncRNA-mediated mechanisms of therapeutic resistance 0.999999999998129 -1.87124611415313e-12 12 0 0 19 5310 WP1425 Bone Morphogenic Protein (BMP) Signalling and Regulation 0.999999999998129 -1.87124611415313e-12 12 0 0 19 5310 WP2007 Iron metabolism in placenta 0.999999999998129 -1.87124611415313e-12 12 0 0 19 5310 WP106 Alanine and aspartate metabolism 0.999999999998129 -1.87124611415313e-12 12 0 0 19 5310 WP2290 RalA downstream regulated genes 0.999999999998129 -1.87124611415313e-12 12 0 0 19 5310 WP3849 MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ 0.999999999998129 -1.87124611415313e-12 12 0 0 19 5310 WP2533 Glycerophospholipid Biosynthetic Pathway 0.999999999998353 -1.64737341052544e-12 21 0 0 19 5310 WP2507 Nanomaterial induced apoptosis 0.999999999998353 -1.64737341052544e-12 21 0 0 19 5310 WP3670 Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway 0.999999999998353 -1.64737341052544e-12 21 0 0 19 5310 WP691 Tamoxifen metabolism 0.999999999998353 -1.64737341052544e-12 21 0 0 19 5310 WP410 Diurnally Regulated Genes with Circadian Orthologs 0.999999999998712 -1.28827108641643e-12 49 0 0 19 5310 WP286 IL-3 Signaling Pathway 0.999999999998712 -1.28827108641643e-12 49 0 0 19 5310 WP534 Glycolysis and Gluconeogenesis 0.999999999998712 -1.28827108641643e-12 49 0 0 19 5310 WP179 Cell Cycle 0.999999999998723 -1.27700564951526e-12 105 0 0 19 5310 WP2542 Sulindac Metabolic Pathway 0.999999999998729 -1.27146706840907e-12 5 0 0 19 5310 WP2868 TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer 0.999999999998729 -1.27146706840907e-12 5 0 0 19 5310 WP311 Synthesis and Degradation of Ketone Bodies 0.999999999998729 -1.27146706840907e-12 5 0 0 19 5310 WP688 Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) 0.999999999998729 -1.27146706840907e-12 5 0 0 19 5310 WP2597 Secretion of Hydrochloric Acid in Parietal Cells 0.999999999998729 -1.27146706840907e-12 5 0 0 19 5310 WP3596 miR-517 relationship with ARCN1 and USP1 0.999999999998729 -1.27146706840907e-12 5 0 0 19 5310 WP2355 Corticotropin-releasing hormone signaling pathway 0.999999999998787 -1.21269500923254e-12 93 0 0 19 5310 WP1530 miRNA Regulation of DNA Damage Response 0.999999999998787 -1.21269500923254e-12 93 0 0 19 5310 WP3286 Copper homeostasis 0.999999999999289 -7.11039298901899e-13 54 0 0 19 5310 WP623 Oxidative phosphorylation 0.999999999999289 -7.11039298901899e-13 54 0 0 19 5310 WP1545 miRNAs involved in DNA damage response 0.999999999999324 -6.76219284350533e-13 50 0 0 19 5310 WP1433 Nucleotide-binding Oligomerization Domain (NOD) pathway 0.999999999999469 -5.3129229590479e-13 41 0 0 19 5310 WP2406 Cardiac Progenitor Differentiation 0.999999999999516 -4.84431395509027e-13 53 0 0 19 5310 WP363 Wnt Signaling Pathway Netpath 0.999999999999516 -4.84431395509027e-13 53 0 0 19 5310 WP107 Translation Factors 0.999999999999516 -4.84431395509027e-13 53 0 0 19 5310 WP2037 Prolactin Signaling Pathway 0.999999999999762 -2.38091460739525e-13 76 0 0 19 5310 WP2034 Leptin signaling pathway 0.999999999999762 -2.38091460739525e-13 76 0 0 19 5310 WP313 Signaling of Hepatocyte Growth Factor Receptor 0.999999999999773 -2.27422106863756e-13 34 0 0 19 5310 WP400 p38 MAPK Signaling Pathway 0.999999999999773 -2.27422106863756e-13 34 0 0 19 5310 WP1601 Fluoropyrimidine Activity 0.999999999999773 -2.27422106863756e-13 34 0 0 19 5310 WP143 Fatty Acid Beta Oxidation 0.999999999999773 -2.27422106863756e-13 34 0 0 19 5310 WP306 Focal Adhesion 1.00000000000001 1.01074515702668e-14 195 0 0 19 5310 WP2377 Integrated Pancreatic Cancer Pathway 1.00000000000014 1.42470152790765e-13 197 0 0 19 5310 WP3624 Lung fibrosis 1.00000000000038 3.82275659336972e-13 63 0 0 19 5310 WP43 Oxidation by Cytochrome P450 1.00000000000038 3.82275659336972e-13 63 0 0 19 5310 WP24 Peptide GPCRs 1.00000000000058 5.81617407578349e-13 74 0 0 19 5310 WP2572 Primary Focal Segmental Glomerulosclerosis FSGS 1.00000000000058 5.81617407578349e-13 74 0 0 19 5310 WP734 Serotonin Receptor 4/6/7 and NR3C Signaling 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP2011 SREBF and miR33 in cholesterol and lipid homeostasis 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP697 Estrogen metabolism 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP404 Nucleotide Metabolism 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP247 Small Ligand GPCRs 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP2879 Farnesoid X Receptor Pathway 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP3877 Simplified Depiction of MYD88 Distinct Input-Output Pathway 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP22 IL-9 Signaling Pathway 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP3287 Overview of nanoparticle effects 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP1992 TarBasePathway 1.00000000000061 6.11632763094085e-13 19 0 0 19 5310 WP23 B Cell Receptor Signaling Pathway 1.00000000000065 6.45555080221042e-13 98 0 0 19 5310 WP437 EGF/EGFR Signaling Pathway 1.00000000000073 7.34608170891399e-13 162 0 0 19 5310 WP117 GPCRs, Other 1.0000000000014 1.39621967003781e-12 95 0 0 19 5310 WP615 Senescence and Autophagy in Cancer 1.00000000000175 1.75343944470171e-12 106 0 0 19 5310 WP1982 Sterol Regulatory Element-Binding Proteins (SREBP) signalling 1.00000000000179 1.79215296859702e-12 73 0 0 19 5310 WP2291 Deregulation of Rab and Rab Effector Genes in Bladder Cancer 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP1946 Cori Cycle 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP12 Osteoclast Signaling 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP2453 TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP53 ID signaling pathway 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP47 Hedgehog Signaling Pathway 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP550 Biogenic Amine Synthesis 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP501 GPCRs, Class C Metabotropic glutamate, pheromone 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP3644 NAD+ metabolism 1.00000000000196 1.95715249329094e-12 16 0 0 19 5310 WP3612 Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling 1.00000000000215 2.14574178061437e-12 23 0 0 19 5310 WP712 Estrogen signaling pathway 1.00000000000215 2.14574178061437e-12 23 0 0 19 5310 WP2112 IL17 signaling pathway 1.00000000000246 2.46316839651267e-12 31 0 0 19 5310 WP3850 Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling 1.00000000000246 2.46316839651267e-12 31 0 0 19 5310 WP3614 Photodynamic therapy-induced HIF-1 survival signaling 1.00000000000252 2.51726389664757e-12 37 0 0 19 5310 WP619 Type II interferon signaling (IFNG) 1.00000000000252 2.51726389664757e-12 37 0 0 19 5310 WP3414 Initiation of transcription and translation elongation at the HIV-1 LTR 1.00000000000252 2.51726389664757e-12 37 0 0 19 5310 WP3529 Zinc homeostasis 1.00000000000252 2.51726389664757e-12 37 0 0 19 5310 WP1471 Target Of Rapamycin (TOR) Signaling 1.00000000000252 2.51726389664757e-12 37 0 0 19 5310 WP2363 Gastric Cancer Network 2 1.00000000000297 2.97148695698738e-12 33 0 0 19 5310 WP453 Inflammatory Response Pathway 1.00000000000297 2.97148695698738e-12 33 0 0 19 5310 WP58 Monoamine GPCRs 1.00000000000297 2.97148695698738e-12 33 0 0 19 5310 WP2853 Endoderm Differentiation 1.00000000000307 3.07086655420079e-12 145 0 0 19 5310 WP51 Regulation of Actin Cytoskeleton 1.00000000000333 3.3261734726896e-12 149 0 0 19 5310 WP2446 Retinoblastoma (RB) in Cancer 1.00000000000342 3.41678903118763e-12 88 0 0 19 5310 WP2190 One carbon donor 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP661 Glucose Homeostasis 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP108 Selenium metabolism/Selenoproteins 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP188 Focal Adhesion 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP1 Statin Pathway 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP2536 Colchicine Metabolic Pathway 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP3191 TSLP Signaling Pathway 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP3627 Gut-Liver Indole Metabolism 1.00000000000362 3.61691492728466e-12 1 0 0 19 5310 WP702 Metapathway biotransformation 1.0000000000042 4.20343490553069e-12 177 0 0 19 5310 WP2435 Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis 1.00000000000472 4.71565280896801e-12 15 0 0 19 5310 WP206 Fatty Acid Omega Oxidation 1.00000000000472 4.71565280896801e-12 15 0 0 19 5310 WP3 Transcriptional activation by NRF2 1.00000000000472 4.71565280896801e-12 15 0 0 19 5310 WP197 Cholesterol Biosynthesis 1.00000000000472 4.71565280896801e-12 15 0 0 19 5310 WP528 Acetylcholine Synthesis 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP3595 mir-124 predicted interactions with cell cycle and differentiation 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP1272 Selenium Micronutrient Network 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP1995 Effects of Nitric Oxide 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP438 Non-homologous end joining 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP2805 RNA interference 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP134 Pentose Phosphate Pathway 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP699 Aflatoxin B1 metabolism 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP678 Arachidonate Epoxygenase / Epoxide Hydrolase 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP2596 Gastric acid production 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP3924 Hfe effect on hepcidin production 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP1310 Selenium Micronutrient Network 1.00000000000473 4.72750287286189e-12 7 0 0 19 5310 WP2865 IL1 and megakaryocytes in obesity 1.00000000000556 5.56255951367039e-12 25 0 0 19 5310 WP205 IL-7 Signaling Pathway 1.00000000000556 5.56255951367039e-12 25 0 0 19 5310 WP2895 Differentiation of white and brown adipocyte 1.00000000000556 5.56255951367039e-12 25 0 0 19 5310 WP3668 Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1.00000000000556 5.56255951367039e-12 25 0 0 19 5310 WP1528 Physiological and Pathological Hypertrophy of the Heart 1.00000000000556 5.56255951367039e-12 25 0 0 19 5310 WP2916 Interactome of polycomb repressive complex 2 (PRC2) 1.00000000000638 6.38031440463386e-12 17 0 0 19 5310 WP78 TCA Cycle 1.00000000000638 6.38031440463386e-12 17 0 0 19 5310 WP3874 Canonical and Non-Canonical TGF-B signaling 1.00000000000638 6.38031440463386e-12 17 0 0 19 5310 WP2289 Drug Induction of Bile Acid Pathway 1.00000000000638 6.38031440463386e-12 17 0 0 19 5310 WP368 Mitochondrial LC-Fatty Acid Beta-Oxidation 1.00000000000638 6.38031440463386e-12 17 0 0 19 5310 WP554 ACE Inhibitor Pathway 1.00000000000638 6.38031440463386e-12 17 0 0 19 5310 WP3678 Amplification and Expansion of Oncogenic Pathways as Metastatic Traits 1.00000000000638 6.38031440463386e-12 17 0 0 19 5310 WP15 Selenium Micronutrient Network 1.0000000000065 6.50216223842272e-12 87 0 0 19 5310 WP3630 NAD metabolism, sirtuins and aging 1.00000000000706 7.06469414126961e-12 11 0 0 19 5310 WP2513 Nanoparticle triggered regulated necrosis 1.00000000000706 7.06469414126961e-12 11 0 0 19 5310 WP1455 Serotonin Transporter Activity 1.00000000000706 7.06469414126961e-12 11 0 0 19 5310 WP80 Nucleotide GPCRs 1.00000000000706 7.06469414126961e-12 11 0 0 19 5310 WP2854 Gene regulatory network modelling somitogenesis 1.00000000000706 7.06469414126961e-12 11 0 0 19 5310 WP1984 Integrated Breast Cancer Pathway 1.00000000000746 7.45809928366369e-12 154 0 0 19 5310 WP366 TGF-beta Signaling Pathway 1.00000000000747 7.46937228491074e-12 133 0 0 19 5310 WP61 Notch Signaling Pathway 1.00000000000937 9.36657716526148e-12 62 0 0 19 5310 WP3863 T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection 1.00000000000937 9.36657716526148e-12 62 0 0 19 5310 WP3584 MECP2 and Associated Rett Syndrome 1.00000000000937 9.36657716526148e-12 62 0 0 19 5310 WP3646 Hepatitis C and Hepatocellular Carcinoma 1.00000000001169 1.16925704086952e-11 51 0 0 19 5310 WP3611 Photodynamic therapy-induced AP-1 survival signaling. 1.00000000001169 1.16925704086952e-11 51 0 0 19 5310