Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.287e-13	-29.68	intracellular signal transduction	biological process	GO:0035556	1505	24	18204	50	PRKAR2A,GUCY1A2,CAMK2D,PRKACB,MRAS,PDE2A,SHOC2,PDE4B,RYR2,PRKCA,KALRN,TIAM2,PDE9A,PLCB1,ADCY8,RASGRF1,GSK3B,ATP2A1,RASD1,ITPR1,GUCY2F,MINK1,PDE1A,PLCE1
1.295e-13	-29.68	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	8	18204	50	PDE9A,PDE1A,PDE4B,PDE2A,CACNB4,GUCY2F,GUCY1A2,ADCY8
1.605e-13	-29.46	cyclic nucleotide metabolic process	biological process	GO:0009187	41	8	18204	50	GUCY1A2,ADCY8,PDE9A,PDE1A,PDE4B,PDE2A,CACNB4,GUCY2F
4.090e-12	-26.22	Circadian entrainment	KEGG pathways	ko04713	96	10	7161	31	ITPR1,GUCY1A2,ADCY8,PRKACB,PRKCA,RYR2,PLCB1,CAMK2D,GRIA3,RASD1
4.090e-12	-26.22	Circadian entrainment	KEGG pathways	hsa04713	96	10	7161	31	PRKCA,PRKACB,PLCB1,RYR2,RASD1,GRIA3,CAMK2D,ADCY8,GUCY1A2,ITPR1
9.506e-11	-23.08	phosphoric diester hydrolase activity	molecular function	GO:0008081	89	8	18094	49	PLCE1,PLCB1,PDE2A,PDE9A,SMPDL3B,PDE1A,PDE4B,PLD3
1.084e-10	-22.95	Calcium signaling pathway	KEGG pathways	hsa04020	181	11	7161	31	CACNA1B,ITPR1,ADCY8,CAMK2D,RYR2,PLCB1,ATP2A1,PRKACB,PRKCA,PLCE1,PDE1A
1.084e-10	-22.95	Calcium signaling pathway	KEGG pathways	ko04020	181	11	7161	31	ADCY8,ITPR1,CACNA1B,CAMK2D,PDE1A,PLCE1,PRKCA,PRKACB,ATP2A1,PLCB1,RYR2
1.593e-10	-22.56	Neuronal System	REACTOME pathways	R-HSA-112316	349	13	10285	38	KCND2,RASGRF1,CACNA1B,CACNB4,PRKACB,GRIA3,PRKCA,SYT10,KCNH6,ADCY8,CAMK2D,SLC18A2,PLCB1
2.962e-10	-21.94	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	7	10285	38	PRKAR2A,ADCY8,PRKACB,ITPR1,PRKCA,PDE1A,PLCB1
3.459e-10	-21.78	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	7	10285	38	PRKCA,PLCB1,PDE1A,PRKAR2A,ADCY8,PRKACB,ITPR1
3.824e-10	-21.68	signaling	biological process	GO:0023052	4968	35	18204	50	ADCY8,KCND2,RASD1,ATP2A1,GSK3B,GUCY2F,PDE1A,PLCE1,CAMK2D,GUCY1A2,RXRA,PRKACB,CACNB4,SLC18A2,SHOC2,RAPSN,PDE9A,KALRN,GRIA3,PLCB1,CBL,CACNA1B,RASGRF1,MINK1,ITPR1,SYT10,PRKAR2A,NR4A2,SLC39A6,PRKCA,RYR2,PDE4B,PDE2A,MRAS,TIAM2
3.923e-10	-21.66	intracellular signaling cassette	biological process	GO:0141124	837	16	18204	50	PDE1A,PLCE1,GUCY2F,ITPR1,MINK1,RASGRF1,RASD1,TIAM2,PDE9A,SHOC2,PDE2A,MRAS,RYR2,PDE4B,GUCY1A2,CAMK2D
4.910e-10	-21.43	cell communication	biological process	GO:0007154	5010	35	18204	50	PRKACB,RXRA,GUCY1A2,CAMK2D,PDE9A,RAPSN,KALRN,CACNB4,SHOC2,SLC18A2,RASD1,GSK3B,ATP2A1,KCND2,ADCY8,PLCE1,PDE1A,GUCY2F,NR4A2,PRKAR2A,TIAM2,PRKCA,SLC39A6,MRAS,PDE2A,PDE4B,RYR2,CBL,CACNA1B,RASGRF1,GRIA3,PLCB1,ITPR1,MINK1,SYT10
6.219e-10	-21.20	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	8	10285	38	PRKCA,PDE1A,PRKACB,PDE4B,PLCB1,PRKAR2A,ITPR1,ADCY8
7.682e-10	-20.99	cGMP metabolic process	biological process	GO:0046068	17	5	18204	50	PDE1A,PDE9A,GUCY1A2,PDE2A,GUCY2F
1.331e-09	-20.44	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	8	7161	31	PLCB1,PRKCA,PRKACB,CAMK2D,NR4A2,ITPR1,PDE2A,ADCY8
1.331e-09	-20.44	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	8	7161	31	CAMK2D,PLCB1,PRKACB,PRKCA,NR4A2,ITPR1,PDE2A,ADCY8
2.099e-09	-19.98	DAG and IP3 signaling	REACTOME pathways	R-HSA-1489509	34	6	10285	38	PDE1A,PRKCA,PRKACB,ADCY8,ITPR1,PRKAR2A
2.333e-09	-19.88	Dopaminergic synapse	KEGG pathways	ko04728	130	9	7161	31	PLCB1,PRKACB,PRKCA,SLC18A2,CAMK2D,GRIA3,GSK3B,CACNA1B,ITPR1
2.333e-09	-19.88	Dopaminergic synapse	KEGG pathways	hsa04728	130	9	7161	31	ITPR1,GSK3B,CACNA1B,PRKCA,PRKACB,PLCB1,CAMK2D,GRIA3,SLC18A2
3.023e-09	-19.62	PLC-gamma1 signalling	REACTOME pathways	R-HSA-167021	36	6	10285	38	PRKAR2A,ITPR1,ADCY8,PRKACB,PRKCA,PDE1A
3.023e-09	-19.62	EGFR interacts with phospholipase C-gamma	REACTOME pathways	R-HSA-212718	36	6	10285	38	PRKAR2A,ITPR1,ADCY8,PRKACB,PRKCA,PDE1A
4.010e-09	-19.33	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	10	10285	38	CAMK2D,SLC18A2,PLCB1,ADCY8,PRKCA,GRIA3,PRKACB,RASGRF1,CACNA1B,CACNB4
9.339e-09	-18.49	Oxytocin signaling pathway	KEGG pathways	hsa04921	152	9	7161	31	PRKACB,PRKCA,PLCB1,RYR2,CAMK2D,GUCY1A2,ADCY8,ITPR1,CACNB4
9.339e-09	-18.49	Oxytocin signaling pathway	KEGG pathways	ko04921	152	9	7161	31	ITPR1,GUCY1A2,ADCY8,CACNB4,PRKACB,PRKCA,RYR2,PLCB1,CAMK2D
2.116e-08	-17.67	Nitric oxide stimulates guanylate cyclase	REACTOME pathways	R-HSA-392154	24	5	10285	38	PDE9A,ITPR1,GUCY1A2,PDE1A,PDE2A
3.577e-08	-17.15	synaptic signaling	biological process	GO:0099536	459	11	18204	50	RAPSN,SYT10,SLC18A2,MINK1,ITPR1,CACNB4,GSK3B,CACNA1B,PLCB1,GRIA3,KCND2
4.841e-08	-16.84	Calmodulin induced events	REACTOME pathways	R-HSA-111933	28	5	10285	38	PRKCA,PDE1A,PRKAR2A,ADCY8,PRKACB
4.841e-08	-16.84	CaM pathway	REACTOME pathways	R-HSA-111997	28	5	10285	38	PRKCA,PDE1A,PRKAR2A,ADCY8,PRKACB
4.939e-08	-16.82	cyclic nucleotide catabolic process	biological process	GO:0009214	14	4	18204	50	PDE2A,PDE4B,PDE1A,PDE9A
5.583e-08	-16.70	regulation of cell communication	biological process	GO:0010646	3541	27	18204	50	NR4A2,PRKACB,RXRA,GUCY1A2,CAMK2D,RAPSN,PDE9A,KALRN,TIAM2,PRKCA,CACNB4,SHOC2,PDE2A,RYR2,PDE4B,CACNA1B,CBL,GARNL3,GSK3B,RASGRF1,GRIA3,ADCY8,PLCB1,ITPR1,GUCY2F,SMPDL3B,MINK1
6.243e-08	-16.59	plasma membrane	cellular component	GO:0005886	5538	33	19108	50	ADCY8,ITPR1,SYT10,NBEA,GRIA3,CACNA1B,PRKCA,PLCE1,SMPDL3B,KCNH6,SLC39A6,GSK3B,SLC18A2,CACNB4,PHACTR2,PDE4B,MRAS,PRKACB,SLC16A14,RYR2,RASD1,PDE9A,RASGRF1,RAB37,CAMK2D,PRKAR2A,RAPSN,KCND2,CBL,GUCY2F,AJM1,PDE2A,DPEP1
6.704e-08	-16.52	anion binding	molecular function	GO:0043168	2412	22	18094	49	ITPR1,ADCY8,RXRA,PRKACB,MRAS,RAB37,PDE4B,CAMK2D,KALRN,PRKCA,PRKAR2A,SYT10,GSK3B,PLCB1,RASD1,CACNA1B,GUCY2F,ATP2A1,PDE2A,GUCY1A2,RYR2,MINK1
6.982e-08	-16.48	Ca-dependent events	REACTOME pathways	R-HSA-111996	30	5	10285	38	PDE1A,PRKCA,PRKACB,ADCY8,PRKAR2A
8.697e-08	-16.26	Morphine addiction	KEGG pathways	ko05032	91	7	7161	31	PDE4B,CACNA1B,PRKACB,PRKCA,PDE1A,ADCY8,PDE2A
8.697e-08	-16.26	Morphine addiction	KEGG pathways	hsa05032	91	7	7161	31	PRKCA,PRKACB,PDE2A,PDE1A,ADCY8,CACNA1B,PDE4B
1.057e-07	-16.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	13	16828	47	KALRN,ADCY8,PDE2A,PDE9A,KCND2,CBL,LRCH1,CACNA1B,PLCB1,RYR2,PDE4B,PRKACB,PDE1A
1.768e-07	-15.55	PDEase	interpro domains	IPR023088	19	4	18521	50	PDE9A,PDE4B,PDE2A,PDE1A
1.794e-07	-15.53	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	7	7161	31	PLCB1,CACNA1B,ADCY8,PRKCA,PRKACB,ITPR1,GRIA3
1.794e-07	-15.53	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	7	7161	31	PLCB1,CACNA1B,PRKACB,PRKCA,ITPR1,ADCY8,GRIA3
1.942e-07	-15.45	cGMP catabolic process	biological process	GO:0046069	5	3	18204	50	PDE2A,PDE1A,PDE9A
2.450e-07	-15.22	signal transduction	biological process	GO:0007165	4637	30	18204	50	RASGRF1,GSK3B,ATP2A1,CBL,RASD1,PLCB1,GRIA3,ADCY8,PDE1A,PLCE1,ITPR1,GUCY2F,MINK1,PRKACB,RXRA,NR4A2,GUCY1A2,PRKAR2A,CAMK2D,KALRN,TIAM2,PDE9A,SHOC2,PDE2A,MRAS,PDE4B,RYR2,CACNB4,PRKCA,SLC39A6
2.719e-07	-15.12	PDEase_catalytic_dom	interpro domains	IPR002073	21	4	18521	50	PDE4B,PDE9A,PDE2A,PDE1A
2.719e-07	-15.12	PDEase_catalytic_dom_sf	interpro domains	IPR036971	21	4	18521	50	PDE9A,PDE4B,PDE1A,PDE2A
2.719e-07	-15.12	PDEase_CS	interpro domains	IPR023174	21	4	18521	50	PDE2A,PDE1A,PDE4B,PDE9A
2.799e-07	-15.09	cell junction	cellular component	GO:0030054	2224	20	19108	50	SYT10,GRIA3,ADCY8,PDE4B,TIAM2,ITPR1,MINK1,CACNA1B,PLCB1,KCND2,SLC18A2,GSK3B,CBL,RAPSN,PRKAR2A,KALRN,AJM1,CACNB4,DPEP1,PDE2A
2.933e-07	-15.04	PDEase_I	pfam domains	PF00233	21	4	17795	49	PDE9A,PDE1A,PDE2A,PDE4B
3.273e-07	-14.93	Long-term potentiation	KEGG pathways	hsa04720	67	6	7161	31	PLCB1,ADCY8,ITPR1,PRKCA,PRKACB,CAMK2D
3.273e-07	-14.93	Long-term potentiation	KEGG pathways	ko04720	67	6	7161	31	CAMK2D,ADCY8,PRKCA,PRKACB,ITPR1,PLCB1
3.349e-07	-14.91	3',5'-cyclic-AMP phosphodiesterase activity	molecular function	GO:0004115	22	4	18094	49	PDE4B,PDE1A,PDE2A,PDE9A
3.565e-07	-14.85	Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME pathways	R-HSA-442755	41	5	10285	38	RASGRF1,PRKACB,ADCY8,CAMK2D,GRIA3
3.658e-07	-14.82	Cholinergic synapse	KEGG pathways	hsa04725	112	7	7161	31	ADCY8,PRKCA,ITPR1,PRKACB,PLCB1,CACNA1B,CAMK2D
3.658e-07	-14.82	Serotonergic synapse	KEGG pathways	hsa04726	112	7	7161	31	KCND2,SLC18A2,ITPR1,PRKACB,PRKCA,CACNA1B,PLCB1
4.007e-07	-14.73	HD/PDEase_dom	interpro domains	IPR003607	23	4	18521	50	PDE4B,PDE9A,PDE2A,PDE1A
4.046e-07	-14.72	3',5'-cyclic-GMP phosphodiesterase activity	molecular function	GO:0047555	23	4	18094	49	PDE2A,PDE9A,PDE1A,PDE4B
4.092e-07	-14.71	G Protein Signaling Pathways	WikiPathways	WP35	95	7	5310	28	PRKCA,PDE4B,ADCY8,PRKACB,ITPR1,PDE1A,PRKAR2A
4.146e-07	-14.70	Regulation of insulin secretion	REACTOME pathways	R-HSA-422356	80	6	10285	38	PLCB1,PRKCA,ITPR1,ADCY8,PRKACB,PRKAR2A
4.354e-07	-14.65	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	20	19108	50	GRIA3,MINK1,PRKACB,TIAM2,PDE4B,ADCY8,RASGRF1,PDE9A,GUCY2F,CBL,GSK3B,SLC18A2,KCND2,SLC39A6,PRKAR2A,PLCE1,CAMK2D,PRKCA,DPEP1,AJM1
4.671e-07	-14.58	cGMP effects	REACTOME pathways	R-HSA-418457	18	4	10285	38	PDE1A,PDE2A,ITPR1,PDE9A
4.846e-07	-14.54	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular function	GO:0004114	24	4	18094	49	PDE2A,PDE9A,PDE1A,PDE4B
5.314e-07	-14.45	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	10	10285	38	CAMK2D,ITPR1,ADCY8,PRKAR2A,PDE1A,PRKCA,CBL,PRKACB,RASGRF1,GSK3B
5.510e-07	-14.41	cell periphery	cellular component	GO:0071944	6020	33	19108	50	PDE9A,RASGRF1,PHACTR2,PDE4B,MRAS,PRKACB,SLC16A14,RYR2,RASD1,AJM1,DPEP1,PDE2A,RAB37,CAMK2D,PRKAR2A,RAPSN,KCND2,GUCY2F,CBL,CACNA1B,ADCY8,ITPR1,SYT10,NBEA,GRIA3,CACNB4,PRKCA,PLCE1,SMPDL3B,KCNH6,SLC39A6,SLC18A2,GSK3B
5.693e-07	-14.38	synapse	cellular component	GO:0045202	1473	16	19108	50	GRIA3,SYT10,PDE4B,ADCY8,MINK1,ITPR1,TIAM2,CACNA1B,PLCB1,SLC18A2,GSK3B,KCND2,RAPSN,KALRN,CACNB4,PDE2A
6.119e-07	-14.31	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	gene3d domains	1.10.1300.10	21	4	14470	48	PDE2A,PDE4B,PDE1A,PDE9A
6.447e-07	-14.25	Gastric acid secretion	KEGG pathways	ko04971	75	6	7161	31	CAMK2D,PRKCA,ITPR1,PRKACB,ADCY8,PLCB1
6.447e-07	-14.25	Gastric acid secretion	KEGG pathways	hsa04971	75	6	7161	31	CAMK2D,PLCB1,ADCY8,PRKCA,ITPR1,PRKACB
6.782e-07	-14.20	PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha)	protein interactions	5576	197	7	19454	50	PRKAR2A,PRKACB,RYR2,CBL,GSK3B,NBEA,PRKCA
6.791e-07	-14.20	cyclic-nucleotide phosphodiesterase activity	molecular function	GO:0004112	26	4	18094	49	PDE4B,PDE1A,PDE2A,PDE9A
6.815e-07	-14.20	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	8	5310	28	ITPR1,CAMK2D,CACNA1B,PRKACB,PRKAR2A,RYR2,ADCY8,PRKCA
7.072e-07	-14.16	inorganic cation transmembrane transport	biological process	GO:0098662	618	11	18204	50	ATP2A1,CACNA1B,PLCB1,KCNH6,KCND2,PLCE1,RYR2,SLC18A2,ITPR1,CACNB4,SLC39A6
7.333e-07	-14.13	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	11	10285	38	CAMK2D,PRKAR2A,ITPR1,ADCY8,PRKCA,PDE1A,KALRN,GSK3B,TIAM2,RASGRF1,PRKACB
8.250e-07	-14.01	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	37	16828	47	DPEP1,GUCY1A2,KALRN,KCND2,MRAS,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,GARNL3,ITPR1,NBEA,PDE4B,TIAM2,RYR2,PRKAR2A,PLCE1,CBL,SMPDL3B,LRCH1,ATP2A1,SHOC2,SLC18A2,PHACTR2,PRKCA,GRIA3,CACNA1B,PDE2A,ADCY8,PDE9A,PDE1A,KCNH6,PLCB1,SYT10,RXRA,SLC16A14
8.460e-07	-13.98	PDEASE_I_1	prosite domains	PS00126	21	4	12186	44	PDE2A,PDE1A,PDE4B,PDE9A
8.460e-07	-13.98	PDEASE_I_2	prosite domains	PS51845	21	4	12186	44	PDE4B,PDE9A,PDE1A,PDE2A
8.782e-07	-13.95	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME pathways	R-HSA-112314	146	7	10285	38	RASGRF1,PRKACB,ADCY8,PLCB1,CAMK2D,GRIA3,PRKCA
8.930e-07	-13.93	Platelet homeostasis	REACTOME pathways	R-HSA-418346	91	6	10285	38	PDE9A,ITPR1,PDE1A,GUCY1A2,PDE2A,ATP2A1
9.378e-07	-13.88	monoatomic cation transmembrane transport	biological process	GO:0098655	636	11	18204	50	ITPR1,CACNB4,SLC39A6,SLC18A2,RYR2,PLCE1,KCND2,PLCB1,KCNH6,CACNA1B,ATP2A1
9.499e-07	-13.87	cell projection	cellular component	GO:0042995	2398	20	19108	50	PLCE1,PRKCA,CAMK2D,PRKAR2A,SLC18A2,GUCY2F,GSK3B,CBL,KCND2,SLC39A6,AJM1,DPEP1,PDE4B,ADCY8,PRKACB,MINK1,TIAM2,GRIA3,PDE9A,RASGRF1
9.643e-07	-13.85	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	8	5310	28	RYR2,PRKACB,PRKAR2A,PRKCA,ADCY8,ITPR1,PDE4B,CAMK2D
1.064e-06	-13.75	calcium channel complex	cellular component	GO:0034704	70	5	19108	50	CACNB4,PDE4B,ATP2A1,CACNA1B,RYR2
1.121e-06	-13.70	Activation of PKC Through G Protein-Coupled Receptor	SMPDB pathways	SMP0000749	4	3	1369	10	ITPR1,PRKCA,PLCB1
1.136e-06	-13.69	regulation of signaling	biological process	GO:0023051	3534	25	18204	50	PDE9A,RAPSN,KALRN,TIAM2,CACNB4,PRKCA,SHOC2,PDE2A,PDE4B,NR4A2,PRKACB,RXRA,GUCY1A2,GUCY2F,ITPR1,SMPDL3B,MINK1,CBL,CACNA1B,GARNL3,RASGRF1,GSK3B,ADCY8,GRIA3,PLCB1
1.213e-06	-13.62	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	17	18204	50	CAMK2D,GUCY1A2,PRKACB,PRKCA,CACNB4,PDE4B,PDE2A,PDE9A,KALRN,ADCY8,PLCB1,GSK3B,MINK1,SMPDL3B,GUCY2F,PDE1A,PLCE1
1.309e-06	-13.55	monoatomic ion transmembrane transport	biological process	GO:0034220	804	12	18204	50	CACNA1B,ATP2A1,GRIA3,KCND2,PLCB1,KCNH6,PLCE1,CACNB4,ITPR1,SLC39A6,RYR2,SLC18A2
1.359e-06	-13.51	Insulin secretion	KEGG pathways	hsa04911	85	6	7161	31	PRKCA,PRKACB,ADCY8,RYR2,PLCB1,CAMK2D
1.374e-06	-13.50	calcium ion transmembrane transport	biological process	GO:0070588	205	7	18204	50	PLCE1,CACNA1B,ATP2A1,ITPR1,CACNB4,PLCB1,RYR2
1.502e-06	-13.41	phosphorus metabolic process	biological process	GO:0006793	1707	17	18204	50	PRKACB,GUCY1A2,CAMK2D,KALRN,PDE9A,PDE2A,PDE4B,CACNB4,PRKCA,GSK3B,PLCB1,ADCY8,PDE1A,PLCE1,GUCY2F,MINK1,SMPDL3B
1.540e-06	-13.38	cellular response to stimulus	biological process	GO:0051716	6307	34	18204	50	TIAM2,PDE2A,MRAS,RYR2,PDE4B,PRKCA,SLC39A6,NR4A2,PRKAR2A,ITPR1,MINK1,RASGRF1,CBL,PLCB1,GRIA3,KALRN,PDE9A,SHOC2,CACNB4,PRKACB,RXRA,GUCY1A2,CAMK2D,PLCE1,PDE1A,GUCY2F,GSK3B,ATP2A1,LRCH1,RASD1,NGB,ADCY8,DPEP1,KCND2
1.605e-06	-13.34	sarcoplasmic reticulum	cellular component	GO:0016529	76	5	19108	50	CAMK2D,ITPR1,RYR2,ATP2A1,RASD1
1.650e-06	-13.31	cell-cell signaling	biological process	GO:0007267	822	12	18204	50	CACNA1B,GSK3B,KCND2,GRIA3,PLCB1,RAPSN,MINK1,ITPR1,CACNB4,SLC18A2,SYT10,RYR2
1.668e-06	-13.30	Gap junction	KEGG pathways	ko04540	88	6	7161	31	PLCB1,PRKACB,ITPR1,PRKCA,GUCY1A2,ADCY8
1.668e-06	-13.30	Gap junction	KEGG pathways	hsa04540	88	6	7161	31	PLCB1,GUCY1A2,ADCY8,ITPR1,PRKCA,PRKACB
1.670e-06	-13.30	chemical synaptic transmission	biological process	GO:0007268	415	9	18204	50	SLC18A2,SYT10,MINK1,CACNB4,RAPSN,KCND2,GRIA3,GSK3B,CACNA1B
1.670e-06	-13.30	anterograde trans-synaptic signaling	biological process	GO:0098916	415	9	18204	50	CACNB4,MINK1,SYT10,SLC18A2,RAPSN,GRIA3,KCND2,CACNA1B,GSK3B
1.773e-06	-13.24	PDIESTERASE1	prints domains	PR00387	19	4	5227	26	PDE9A,PDE2A,PDE1A,PDE4B
1.905e-06	-13.17	Salivary secretion	KEGG pathways	hsa04970	90	6	7161	31	PLCB1,PRKACB,PRKCA,ITPR1,GUCY1A2,ADCY8
1.905e-06	-13.17	Salivary secretion	KEGG pathways	ko04970	90	6	7161	31	GUCY1A2,ADCY8,PRKACB,ITPR1,PRKCA,PLCB1
1.922e-06	-13.16	response to stimulus	biological process	GO:0050896	7803	38	18204	50	NR4A2,PRKAR2A,TIAM2,PRKCA,SLC39A6,PDE2A,MRAS,RYR2,PDE4B,CACNA1B,CBL,RASGRF1,GRIA3,PLCB1,PLD3,ITPR1,MINK1,SMPDL3B,PRKACB,RXRA,GUCY1A2,CAMK2D,PDE9A,KALRN,CACNB4,SHOC2,SLC18A2,RASD1,ATP2A1,GSK3B,LRCH1,DPEP1,KCND2,ADCY8,NGB,PLCE1,PDE1A,GUCY2F
2.017e-06	-13.11	Adrenergic signaling in cardiomyocytes	KEGG pathways	hsa04261	144	7	7161	31	RYR2,PLCB1,CACNB4,PRKCA,PRKACB,ADCY8,CAMK2D
2.017e-06	-13.11	Adrenergic signaling in cardiomyocytes	KEGG pathways	ko04261	144	7	7161	31	CAMK2D,ADCY8,PRKACB,PRKCA,CACNB4,PLCB1,RYR2
2.169e-06	-13.04	GnRH signaling pathway	KEGG pathways	ko04912	92	6	7161	31	PLCB1,ITPR1,PRKACB,PRKCA,ADCY8,CAMK2D
2.169e-06	-13.04	GnRH signaling pathway	KEGG pathways	hsa04912	92	6	7161	31	PRKCA,ITPR1,PRKACB,ADCY8,PLCB1,CAMK2D
2.279e-06	-12.99	trans-synaptic signaling	biological process	GO:0099537	431	9	18204	50	MINK1,CACNB4,SYT10,SLC18A2,RAPSN,KCND2,GRIA3,CACNA1B,GSK3B
2.465e-06	-12.91	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	9	18094	49	CACNA1B,KCNH6,ATP2A1,KCND2,RYR2,ITPR1,SLC18A2,CACNB4,SLC39A6
2.476e-06	-12.91	regulation of cardiac muscle cell contraction	biological process	GO:0086004	35	4	18204	50	ATP2A1,RYR2,CAMK2D,PDE4B
2.620e-06	-12.85	Pancreatic secretion	KEGG pathways	hsa04972	95	6	7161	31	ADCY8,ATP2A1,PRKCA,ITPR1,PLCB1,RYR2
2.620e-06	-12.85	Pancreatic secretion	KEGG pathways	ko04972	95	6	7161	31	ADCY8,ITPR1,ATP2A1,PRKCA,PLCB1,RYR2
2.769e-06	-12.80	HDc	smart domains	SM00471	23	4	9717	43	PDE2A,PDE9A,PDE1A,PDE4B
2.826e-06	-12.78	monoatomic ion channel complex	cellular component	GO:0034702	344	8	19108	50	PDE4B,KCND2,RYR2,GRIA3,KCNH6,CACNB4,CACNA1B,ATP2A1
2.875e-06	-12.76	Integration of energy metabolism	REACTOME pathways	R-HSA-163685	111	6	10285	38	PRKCA,PLCB1,PRKAR2A,PRKACB,ITPR1,ADCY8
2.887e-06	-12.76	postsynaptic specialization	cellular component	GO:0099572	345	8	19108	50	KALRN,MINK1,RAPSN,ITPR1,ADCY8,PDE4B,KCND2,GRIA3
2.928e-06	-12.74	inorganic ion transmembrane transport	biological process	GO:0098660	715	11	18204	50	CACNA1B,ATP2A1,KCND2,PLCB1,KCNH6,PLCE1,ITPR1,CACNB4,SLC39A6,RYR2,SLC18A2
2.961e-06	-12.73	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	6	7161	31	PLCB1,ITPR1,PRKCA,PRKACB,ADCY8,CAMK2D
2.961e-06	-12.73	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	6	7161	31	PRKACB,ITPR1,PRKCA,ADCY8,PLCB1,CAMK2D
3.236e-06	-12.64	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	10	18094	49	RYR2,GRIA3,KCND2,ATP2A1,KCNH6,CACNA1B,SLC39A6,CACNB4,SLC18A2,ITPR1
3.752e-06	-12.49	Melanogenesis	KEGG pathways	ko04916	101	6	7161	31	PRKCA,PRKACB,ADCY8,GSK3B,PLCB1,CAMK2D
3.752e-06	-12.49	Melanogenesis	KEGG pathways	hsa04916	101	6	7161	31	PLCB1,GSK3B,ADCY8,PRKACB,PRKCA,CAMK2D
3.937e-06	-12.45	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	9	10285	38	ITPR1,ADCY8,PRKAR2A,CAMK2D,PRKACB,RASGRF1,GSK3B,PDE1A,PRKCA
4.021e-06	-12.42	RYR2 (ryanodine receptor 2)	protein interactions	6262	42	4	19454	50	RYR2,PRKACB,PRKAR2A,ITPR1
4.182e-06	-12.38	ion binding	molecular function	GO:0043167	6007	32	18094	49	PRKCA,KALRN,PRKAR2A,PDE9A,KCND2,SMPDL3B,CAMK2D,NGB,RXRA,ATP2A1,CACNA1B,GUCY2F,GSK3B,SYT10,PDE4B,MRAS,RAB37,DPEP1,ITPR1,ADCY8,PRKACB,PDE2A,RYR2,GUCY1A2,MINK1,PDE1A,NR4A2,RAPSN,PLCE1,RASD1,CBL,PLCB1
4.198e-06	-12.38	purine ribonucleotide binding	molecular function	GO:0032555	1871	17	18094	49	GSK3B,RASD1,CACNA1B,GUCY2F,ATP2A1,GUCY1A2,PDE2A,MINK1,ADCY8,PRKACB,MRAS,RAB37,PDE4B,CAMK2D,KALRN,PRKCA,PRKAR2A
4.318e-06	-12.35	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	9	10285	38	ITPR1,ADCY8,PRKAR2A,CAMK2D,RASGRF1,PRKACB,GSK3B,PDE1A,PRKCA
4.731e-06	-12.26	cAMP-mediated signaling	biological process	GO:0019933	41	4	18204	50	PDE4B,PDE2A,PDE9A,PDE1A
4.731e-06	-12.26	regulation of actin filament-based movement	biological process	GO:1903115	41	4	18204	50	ATP2A1,CAMK2D,PDE4B,RYR2
4.750e-06	-12.26	ribonucleotide binding	molecular function	GO:0032553	1888	17	18094	49	CAMK2D,PDE4B,PRKAR2A,KALRN,PRKCA,PRKACB,ADCY8,RAB37,MRAS,GUCY2F,CACNA1B,MINK1,GUCY1A2,PDE2A,ATP2A1,GSK3B,RASD1
4.943e-06	-12.22	transmembrane transport	biological process	GO:0055085	1264	14	18204	50	SLC18A2,RYR2,SHOC2,SLC39A6,ITPR1,CACNB4,PLCE1,KCNH6,PLCB1,SLC16A14,GRIA3,KCND2,ATP2A1,CACNA1B
5.011e-06	-12.20	Long-term depression	KEGG pathways	hsa04730	60	5	7161	31	GRIA3,PLCB1,GUCY1A2,PRKCA,ITPR1
5.011e-06	-12.20	Long-term depression	KEGG pathways	ko04730	60	5	7161	31	GRIA3,PLCB1,GUCY1A2,ITPR1,PRKCA
5.105e-06	-12.19	sarcoplasm	cellular component	GO:0016528	96	5	19108	50	CAMK2D,ITPR1,ATP2A1,RYR2,RASD1
5.236e-06	-12.16	phosphoric ester hydrolase activity	molecular function	GO:0042578	362	8	18094	49	PDE9A,PDE2A,PLD3,PDE4B,PDE1A,SMPDL3B,PLCE1,PLCB1
5.250e-06	-12.16	calcium ion transport	biological process	GO:0006816	251	7	18204	50	RYR2,PLCB1,CACNB4,ITPR1,ATP2A1,CACNA1B,PLCE1
5.506e-06	-12.11	postsynapse	cellular component	GO:0098794	646	10	19108	50	ADCY8,PDE4B,ITPR1,MINK1,RAPSN,GRIA3,KCND2,GSK3B,KALRN,PLCB1
5.665e-06	-12.08	monoatomic cation transport	biological process	GO:0006812	766	11	18204	50	SLC18A2,RYR2,SLC39A6,CACNB4,ITPR1,PLCE1,KCNH6,PLCB1,KCND2,ATP2A1,CACNA1B
6.047e-06	-12.02	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	9	10285	38	PRKAR2A,ITPR1,ADCY8,CAMK2D,GSK3B,PRKACB,RASGRF1,PRKCA,PDE1A
6.125e-06	-12.00	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	5	18204	50	CACNA1B,PLCE1,RYR2,PLCB1,ITPR1
6.653e-06	-11.92	protein kinase A catalytic subunit binding	molecular function	GO:0034236	14	3	18094	49	RYR2,PRKAR2A,GSK3B
6.742e-06	-11.91	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	9	10285	38	PRKAR2A,ADCY8,ITPR1,CAMK2D,GSK3B,RASGRF1,PRKACB,PRKCA,PDE1A
6.748e-06	-11.91	metal ion transport	biological process	GO:0030001	630	10	18204	50	RYR2,SLC39A6,CACNB4,ITPR1,PLCE1,KCNH6,PLCB1,KCND2,ATP2A1,CACNA1B
6.855e-06	-11.89	Purine metabolism	KEGG pathways	ko00230	173	7	7161	31	ADCY8,PDE2A,PDE1A,GUCY1A2,GUCY2F,PDE9A,PDE4B
6.855e-06	-11.89	Purine metabolism	KEGG pathways	hsa00230	173	7	7161	31	ADCY8,PDE2A,PDE1A,GUCY1A2,PDE4B,PDE9A,GUCY2F
6.909e-06	-11.88	modulation of chemical synaptic transmission	biological process	GO:0050804	494	9	18204	50	CACNB4,RAPSN,PDE9A,ADCY8,GRIA3,PLCB1,CACNA1B,RASGRF1,GSK3B
7.023e-06	-11.87	regulation of trans-synaptic signaling	biological process	GO:0099177	495	9	18204	50	GRIA3,ADCY8,PLCB1,CACNA1B,GSK3B,RASGRF1,CACNB4,RAPSN,PDE9A
7.297e-06	-11.83	purine ribonucleotide metabolic process	biological process	GO:0009150	373	8	18204	50	GUCY1A2,ADCY8,PDE4B,PDE2A,GUCY2F,CACNB4,PDE9A,PDE1A
7.465e-06	-11.81	Renin secretion	KEGG pathways	hsa04924	65	5	7161	31	PLCB1,PDE1A,GUCY1A2,PRKACB,ITPR1
7.465e-06	-11.81	Renin secretion	KEGG pathways	ko04924	65	5	7161	31	PLCB1,ITPR1,PRKACB,GUCY1A2,PDE1A
7.592e-06	-11.79	Glutamatergic synapse	KEGG pathways	ko04724	114	6	7161	31	PLCB1,PRKACB,ITPR1,PRKCA,ADCY8,GRIA3
7.592e-06	-11.79	Glutamatergic synapse	KEGG pathways	hsa04724	114	6	7161	31	ADCY8,PRKCA,ITPR1,PRKACB,PLCB1,GRIA3
8.105e-06	-11.72	purine nucleotide binding	molecular function	GO:0017076	1964	17	18094	49	MINK1,PDE2A,GUCY1A2,ATP2A1,GUCY2F,CACNA1B,RASD1,GSK3B,PRKAR2A,PRKCA,KALRN,CAMK2D,PDE4B,RAB37,MRAS,PRKACB,ADCY8
8.396e-06	-11.69	Thyroid hormone signaling pathway	KEGG pathways	hsa04919	116	6	7161	31	PLCE1,PRKCA,PRKACB,PLCB1,GSK3B,RXRA
8.512e-06	-11.67	monoatomic ion transport	biological process	GO:0006811	964	12	18204	50	CACNA1B,ATP2A1,KCND2,GRIA3,KCNH6,PLCB1,PLCE1,SLC39A6,ITPR1,CACNB4,RYR2,SLC18A2
8.516e-06	-11.67	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	9	10285	38	RASGRF1,PRKACB,GSK3B,PDE1A,PRKCA,ITPR1,ADCY8,PRKAR2A,CAMK2D
8.795e-06	-11.64	somatodendritic compartment	cellular component	GO:0036477	842	11	19108	50	PDE9A,PDE1A,CACNA1B,MINK1,TIAM2,PDE4B,ADCY8,GSK3B,SLC18A2,KCND2,GRIA3
8.809e-06	-11.64	small molecule binding	molecular function	GO:0036094	6197	32	18094	49	NGB,RXRA,PRKCA,KALRN,PDE9A,PRKAR2A,KCND2,CAMK2D,SMPDL3B,GSK3B,ATP2A1,CACNA1B,GUCY2F,MRAS,RAB37,ITPR1,DPEP1,ADCY8,PRKACB,SYT10,PDE4B,RAPSN,RASD1,PLCE1,CBL,PLCB1,RYR2,GUCY1A2,PDE2A,MINK1,PDE1A,NR4A2
8.908e-06	-11.63	-	gene3d domains	1.10.287.70	148	6	14470	48	KCND2,GRIA3,RYR2,KCNH6,CACNA1B,ITPR1
9.335e-06	-11.58	Amphetamine addiction	KEGG pathways	ko05031	68	5	7161	31	SLC18A2,CAMK2D,GRIA3,PRKCA,PRKACB
9.335e-06	-11.58	Amphetamine addiction	KEGG pathways	hsa05031	68	5	7161	31	SLC18A2,CAMK2D,GRIA3,PRKACB,PRKCA
9.587e-06	-11.56	Post NMDA receptor activation events	REACTOME pathways	R-HSA-438064	37	4	10285	38	PRKACB,ADCY8,RASGRF1,CAMK2D
1.067e-05	-11.45	ribonucleotide metabolic process	biological process	GO:0009259	393	8	18204	50	PDE9A,PDE1A,GUCY2F,CACNB4,PDE4B,PDE2A,ADCY8,GUCY1A2
1.071e-05	-11.44	Vascular smooth muscle contraction	KEGG pathways	ko04270	121	6	7161	31	PRKCA,ITPR1,PRKACB,ADCY8,GUCY1A2,PLCB1
1.071e-05	-11.44	Vascular smooth muscle contraction	KEGG pathways	hsa04270	121	6	7161	31	PLCB1,PRKACB,PRKCA,ITPR1,ADCY8,GUCY1A2
1.105e-05	-11.41	Ion_trans_dom	interpro domains	IPR005821	109	5	18521	50	CACNA1B,KCND2,RYR2,ITPR1,KCNH6
1.113e-05	-11.41	organophosphate catabolic process	biological process	GO:0046434	185	6	18204	50	PDE9A,PDE1A,SMPDL3B,PDE4B,PLCB1,PDE2A
1.196e-05	-11.33	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	6	10285	38	KCND2,ITPR1,CACNB4,ATP2A1,CAMK2D,RYR2
1.197e-05	-11.33	carbohydrate derivative binding	molecular function	GO:0097367	2251	18	18094	49	KALRN,PRKCA,PRKAR2A,CAMK2D,PDE4B,MRAS,RAB37,ADCY8,PRKACB,DPEP1,PDE2A,GUCY1A2,MINK1,ATP2A1,GUCY2F,CACNA1B,RASD1,GSK3B
1.210e-05	-11.32	Ion_trans	pfam domains	PF00520	109	5	17795	49	KCNH6,CACNA1B,ITPR1,RYR2,KCND2
1.226e-05	-11.31	A/G_cyclase_CS	interpro domains	IPR018297	17	3	18521	50	GUCY1A2,ADCY8,GUCY2F
1.375e-05	-11.19	ribose phosphate metabolic process	biological process	GO:0019693	407	8	18204	50	PDE9A,PDE1A,PDE4B,PDE2A,GUCY2F,CACNB4,GUCY1A2,ADCY8
1.417e-05	-11.16	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	5	7161	31	PLCB1,ADCY8,PRKCA,PRKACB,ITPR1
1.417e-05	-11.16	Thyroid hormone synthesis	KEGG pathways	ko04918	74	5	7161	31	PLCB1,ADCY8,PRKACB,ITPR1,PRKCA
1.468e-05	-11.13	A/G_cyclase	interpro domains	IPR001054	18	3	18521	50	GUCY1A2,ADCY8,GUCY2F
1.468e-05	-11.13	Nucleotide_cyclase	interpro domains	IPR029787	18	3	18521	50	GUCY1A2,ADCY8,GUCY2F
1.520e-05	-11.09	cation channel complex	cellular component	GO:0034703	205	6	19108	50	CACNA1B,ATP2A1,RYR2,KCND2,PDE4B,CACNB4
1.545e-05	-11.08	transmembrane transporter complex	cellular component	GO:1902495	434	8	19108	50	CACNB4,ATP2A1,CACNA1B,PDE4B,RYR2,KCNH6,GRIA3,KCND2
1.555e-05	-11.07	Guanylate_cyc	pfam domains	PF00211	18	3	17795	49	ADCY8,GUCY2F,GUCY1A2
1.603e-05	-11.04	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	REACTOME pathways	R-HSA-381676	42	4	10285	38	PRKAR2A,PRKACB,ITPR1,ADCY8
1.663e-05	-11.00	cAMP signaling pathway	KEGG pathways	hsa04024	198	7	7161	31	GRIA3,PDE4B,CAMK2D,RYR2,ADCY8,PLCE1,PRKACB
1.663e-05	-11.00	cAMP signaling pathway	KEGG pathways	ko04024	198	7	7161	31	ADCY8,PLCE1,PRKACB,RYR2,GRIA3,PDE4B,CAMK2D
1.665e-05	-11.00	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	4	18204	50	ITPR1,RYR2,PLCB1,PLCE1
1.673e-05	-11.00	tat (Tat)	protein interactions	155871	1718	15	19454	50	PRKACB,PLCE1,PRKAR2A,GARNL3,PDE2A,PDE1A,GUCY1A2,GRIA3,PDE4B,RYR2,GSK3B,ADCY8,ITPR1,PRKCA,PLCB1
1.750e-05	-10.95	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	10	18094	49	KCND2,RYR2,GRIA3,KCNH6,ATP2A1,CACNA1B,SLC39A6,CACNB4,ITPR1,SLC18A2
1.787e-05	-10.93	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	4	18204	50	ITPR1,RYR2,PLCB1,PLCE1
1.834e-05	-10.91	intracellular calcium ion homeostasis	biological process	GO:0006874	202	6	18204	50	ADCY8,ITPR1,CACNB4,RYR2,CAMK2D,ATP2A1
1.905e-05	-10.87	PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta)	protein interactions	5577	128	5	19454	50	PRKAR2A,RYR2,PRKACB,PRKCA,NBEA
1.956e-05	-10.84	Proteoglycans in cancer	KEGG pathways	hsa05205	203	7	7161	31	PLCE1,ITPR1,PRKCA,PRKACB,CAMK2D,MRAS,CBL
1.956e-05	-10.84	Proteoglycans in cancer	KEGG pathways	ko05205	203	7	7161	31	ITPR1,PRKCA,PRKACB,PLCE1,CAMK2D,CBL,MRAS
2.071e-05	-10.78	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	24	16828	47	CACNB4,RYR2,PLCB1,SLC16A14,SYT10,PDE4B,PDE1A,TIAM2,KCNH6,NBEA,ADCY8,PDE2A,PDE9A,GRIA3,CACNA1B,ITPR1,GARNL3,PHACTR2,GUCY2F,GUCY1A2,KALRN,KCND2,CBL,LRCH1
2.071e-05	-10.78	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	24	16828	47	PHACTR2,GUCY2F,GUCY1A2,KALRN,KCND2,CBL,LRCH1,PLCB1,RYR2,CACNB4,SYT10,SLC16A14,PDE4B,KCNH6,PDE1A,TIAM2,NBEA,PDE9A,ADCY8,PDE2A,GRIA3,ITPR1,GARNL3,CACNA1B
2.151e-05	-10.75	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	GO:0106070	20	3	18204	50	PDE2A,PDE4B,PRKCA
2.164e-05	-10.74	regulation of heart contraction	biological process	GO:0008016	208	6	18204	50	RYR2,PDE4B,CAMK2D,KCNH6,KCND2,ATP2A1
2.192e-05	-10.73	regulation of cytosolic calcium ion concentration	biological process	GO:0051480	60	4	18204	50	ITPR1,ADCY8,CACNB4,RYR2
2.214e-05	-10.72	positive regulation of ATPase-coupled calcium transmembrane transporter activity	biological process	GO:1901896	3	2	18204	50	RYR2,ATP2A1
2.275e-05	-10.69	Apelin signaling pathway	KEGG pathways	hsa04371	138	6	7161	31	MRAS,RYR2,PLCB1,PRKACB,ITPR1,ADCY8
2.301e-05	-10.68	gated channel activity	molecular function	GO:0022836	320	7	18094	49	KCNH6,CACNB4,KCND2,GRIA3,RYR2,CACNA1B,ITPR1
2.337e-05	-10.66	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	41	16828	47	PDE4B,TIAM2,PLCE1,CELF3,PRKAR2A,RYR2,NR4A2,ITPR1,RASD1,GARNL3,GUCY2F,RASGRF1,PRKACB,SLC39A6,CAMK2D,RAPSN,FOXD3,DPEP1,GUCY1A2,KALRN,MRAS,KCND2,KCNH6,RAB37,PLCB1,CACNB4,SYT10,SLC16A14,GRIA3,CACNA1B,ADCY8,PDE9A,PDE2A,SLC18A2,SHOC2,PHACTR2,PRKCA,SMPDL3B,CBL,LRCH1,PLD3
2.354e-05	-10.66	nucleotide binding	molecular function	GO:0000166	2128	17	18094	49	GUCY2F,CACNA1B,GUCY1A2,PDE2A,MINK1,ATP2A1,GSK3B,RASD1,CAMK2D,PDE4B,PRKCA,KALRN,PRKAR2A,ADCY8,PRKACB,MRAS,RAB37
2.369e-05	-10.65	nucleoside phosphate binding	molecular function	GO:1901265	2129	17	18094	49	CACNA1B,GUCY2F,ATP2A1,MINK1,GUCY1A2,PDE2A,GSK3B,RASD1,PDE4B,CAMK2D,PRKAR2A,KALRN,PRKCA,PRKACB,ADCY8,RAB37,MRAS
2.377e-05	-10.65	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	41	16828	47	GARNL3,ITPR1,RASD1,CELF3,PLCE1,PRKAR2A,RYR2,NR4A2,PDE4B,TIAM2,DPEP1,GUCY1A2,KALRN,MRAS,KCND2,RAPSN,FOXD3,GUCY2F,RASGRF1,PRKACB,CAMK2D,SLC39A6,ADCY8,PDE2A,PDE9A,GRIA3,CACNA1B,PLCB1,RAB37,CACNB4,SYT10,SLC16A14,KCNH6,PLD3,SMPDL3B,CBL,LRCH1,PHACTR2,PRKCA,SLC18A2,SHOC2
2.383e-05	-10.64	transporter complex	cellular component	GO:1990351	461	8	19108	50	CACNB4,CACNA1B,ATP2A1,PDE4B,KCNH6,GRIA3,RYR2,KCND2
2.399e-05	-10.64	cyclase activity	molecular function	GO:0009975	21	3	18094	49	GUCY1A2,GUCY2F,ADCY8
2.481e-05	-10.60	cellular response to nitrogen compound	biological process	GO:1901699	580	9	18204	50	DPEP1,ADCY8,PLCB1,NR4A2,GSK3B,ITPR1,RYR2,PDE2A,SHOC2
2.504e-05	-10.59	cyclic nucleotide biosynthetic process	biological process	GO:0009190	21	3	18204	50	GUCY1A2,ADCY8,GUCY2F
2.521e-05	-10.59	PKA activation	REACTOME pathways	R-HSA-163615	16	3	10285	38	PRKACB,ADCY8,PRKAR2A
2.699e-05	-10.52	Nucleotide cyclase	gene3d domains	3.30.70.1230	18	3	14470	48	GUCY2F,ADCY8,GUCY1A2
2.731e-05	-10.51	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	10	18094	49	SLC39A6,CACNB4,SLC18A2,ITPR1,RYR2,GRIA3,KCND2,KCNH6,ATP2A1,CACNA1B
2.883e-05	-10.45	GUANYLATE_CYCLASE_1	prosite domains	PS00452	17	3	12186	44	GUCY2F,ADCY8,GUCY1A2
3.053e-05	-10.40	PKA activation in glucagon signalling	REACTOME pathways	R-HSA-164378	17	3	10285	38	ADCY8,PRKACB,PRKAR2A
3.053e-05	-10.40	PKA-mediated phosphorylation of CREB	REACTOME pathways	R-HSA-111931	17	3	10285	38	ADCY8,PRKACB,PRKAR2A
3.058e-05	-10.40	PRKACA (protein kinase cAMP-activated catalytic subunit alpha)	protein interactions	5566	486	8	19454	50	GSK3B,ITPR1,RYR2,CBL,PRKACB,RASGRF1,PRKAR2A,PDE4B
3.060e-05	-10.39	purine nucleotide metabolic process	biological process	GO:0006163	455	8	18204	50	PDE9A,PDE1A,PDE4B,PDE2A,GUCY2F,CACNB4,GUCY1A2,ADCY8
3.119e-05	-10.38	brainstem	COSMIC cancer mutations	brainstem	3102	21	16828	47	LRCH1,CBL,KCND2,GUCY1A2,KALRN,ATP2A1,CAMK2D,GUCY2F,PRKCA,ITPR1,GARNL3,GRIA3,ADCY8,PDE2A,NBEA,PDE1A,TIAM2,SYT10,PLCB1,PLCE1,RYR2
3.142e-05	-10.37	regulation of sequestering of calcium ion	biological process	GO:0051282	133	5	18204	50	PLCB1,CAMK2D,RYR2,ITPR1,PLCE1
3.148e-05	-10.37	response to oxygen levels	biological process	GO:0070482	331	7	18204	50	CBL,NR4A2,KCND2,ITPR1,RYR2,NGB,GUCY1A2
3.182e-05	-10.36	phosphorus-oxygen lyase activity	molecular function	GO:0016849	23	3	18094	49	GUCY2F,ADCY8,GUCY1A2
3.258e-05	-10.33	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	5	18094	49	CACNB4,ATP2A1,RYR2,ITPR1,CACNA1B
3.322e-05	-10.31	cAMP metabolic process	biological process	GO:0046058	23	3	18204	50	CACNB4,ADCY8,PDE4B
3.343e-05	-10.31	organophosphate metabolic process	biological process	GO:0019637	926	11	18204	50	PDE2A,PDE4B,GUCY2F,CACNB4,SMPDL3B,PDE1A,PLCE1,PDE9A,PLCB1,GUCY1A2,ADCY8
3.451e-05	-10.27	GUANYLATE_CYCLASE_2	prosite domains	PS50125	18	3	12186	44	GUCY1A2,ADCY8,GUCY2F
3.626e-05	-10.22	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	3	5310	28	RYR2,ITPR1,PLCB1
3.629e-05	-10.22	cAMP binding	molecular function	GO:0030552	24	3	18094	49	PRKAR2A,PDE2A,PDE4B
3.899e-05	-10.15	calcium ion homeostasis	biological process	GO:0055074	231	6	18204	50	ATP2A1,ADCY8,CACNB4,ITPR1,RYR2,CAMK2D
3.901e-05	-10.15	cellular response to chemical stimulus	biological process	GO:0070887	2411	18	18204	50	LRCH1,GSK3B,CBL,NGB,PLCB1,DPEP1,ADCY8,KCND2,ITPR1,RXRA,NR4A2,CAMK2D,PDE4B,RYR2,PDE2A,MRAS,SHOC2,CACNB4
4.026e-05	-10.12	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	22	16828	47	SLC18A2,GUCY2F,PRKCA,CBL,KCND2,KALRN,GUCY1A2,TIAM2,SYT10,SLC16A14,RXRA,PRKAR2A,RYR2,CACNB4,PLCB1,PLCE1,CACNA1B,ITPR1,GRIA3,ADCY8,PDE9A,NBEA
4.105e-05	-10.10	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	12	16828	47	PDE4B,PDE1A,RYR2,PLCB1,CBL,CACNA1B,GUCY1A2,KALRN,NBEA,KCND2,ADCY8,MRAS
4.195e-05	-10.08	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	9	18094	49	ATP2A1,KCNH6,RYR2,KCND2,CACNA1B,CACNB4,SLC39A6,SLC18A2,ITPR1
4.673e-05	-9.97	purine-containing compound metabolic process	biological process	GO:0072521	483	8	18204	50	GUCY1A2,ADCY8,PDE1A,PDE9A,PDE2A,PDE4B,GUCY2F,CACNB4
4.848e-05	-9.93	endoplasmic reticulum calcium ion homeostasis	biological process	GO:0032469	26	3	18204	50	ITPR1,CAMK2D,ATP2A1
5.070e-05	-9.89	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	4	10285	38	RYR2,CAMK2D,ATP2A1,ITPR1
5.234e-05	-9.86	heterocyclic compound binding	molecular function	GO:1901363	2263	17	18094	49	PDE4B,CAMK2D,PRKAR2A,KALRN,PRKCA,PRKACB,ADCY8,RAB37,MRAS,CACNA1B,GUCY2F,ATP2A1,MINK1,GUCY1A2,PDE2A,GSK3B,RASD1
5.257e-05	-9.85	CYCc	smart domains	SM00044	17	3	9717	43	GUCY1A2,ADCY8,GUCY2F
5.301e-05	-9.84	regulation of calcium ion transmembrane transporter activity	biological process	GO:1901019	75	4	18204	50	CAMK2D,RYR2,CACNB4,ATP2A1
5.569e-05	-9.80	CD5 (CD5 molecule)	protein interactions	921	29	3	19454	50	PRKCA,CAMK2D,CBL
5.703e-05	-9.77	membrane	cellular component	GO:0016020	9220	38	19108	50	PDE9A,RASGRF1,MRAS,SLC16A14,PRKACB,PHACTR2,PDE4B,RASD1,RYR2,PDE2A,DPEP1,AJM1,PRKAR2A,RAPSN,RAB37,CAMK2D,KCND2,GUCY2F,CBL,PLCB1,CACNA1B,TIAM2,ITPR1,ADCY8,NBEA,SYT10,GRIA3,CACNB4,KALRN,ATP2A1,PLD3,PRKCA,SMPDL3B,PLCE1,SLC39A6,SLC18A2,GSK3B,KCNH6
5.728e-05	-9.77	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	33	16828	47	NR4A2,PLCE1,RYR2,TIAM2,PDE4B,NBEA,GARNL3,ITPR1,RASD1,FOXD3,GUCY2F,RASGRF1,KCND2,KALRN,GUCY1A2,SLC16A14,SYT10,RXRA,PLCB1,KCNH6,PDE1A,PDE9A,ADCY8,PDE2A,GRIA3,PRKCA,PHACTR2,SLC18A2,PLD3,ATP2A1,LRCH1,SMPDL3B,CBL
5.826e-05	-9.75	GPD2 (glycerol-3-phosphate dehydrogenase 2)	protein interactions	2820	82	4	19454	50	ATP2A1,GSK3B,PLD3,SLC18A2
5.826e-05	-9.75	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	6	7161	31	PLCB1,ATP2A1,ITPR1,ADCY8,GUCY1A2,PDE2A
5.826e-05	-9.75	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	6	7161	31	PLCB1,ADCY8,GUCY1A2,PDE2A,ITPR1,ATP2A1
5.920e-05	-9.73	regulation of muscle system process	biological process	GO:0090257	249	6	18204	50	PDE9A,ATP2A1,PRKCA,CAMK2D,PDE4B,RYR2
6.035e-05	-9.72	Common Pathways Underlying Drug Addiction	WikiPathways	WP2636	42	4	5310	28	PRKACB,GRIA3,ADCY8,PRKCA
6.134e-05	-9.70	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	22	16828	47	CACNA1B,GRIA3,PDE9A,PDE2A,NBEA,NPL,TIAM2,PDE1A,KCNH6,PDE4B,RYR2,PLCB1,PLCE1,CBL,KCND2,MRAS,ATP2A1,KALRN,GUCY1A2,CAMK2D,GUCY2F,PRKCA
6.134e-05	-9.70	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	22	16828	47	PDE9A,PDE2A,NBEA,NPL,CACNA1B,GRIA3,RYR2,PLCB1,PLCE1,PDE1A,TIAM2,KCNH6,PDE4B,KCND2,MRAS,ATP2A1,KALRN,GUCY1A2,CBL,PRKCA,CAMK2D,GUCY2F
6.184e-05	-9.69	regulation of cardiac muscle contraction	biological process	GO:0055117	78	4	18204	50	CAMK2D,RYR2,PDE4B,ATP2A1
6.466e-05	-9.65	regulation of transporter activity	biological process	GO:0032409	253	6	18204	50	RXRA,ATP2A1,MINK1,CACNB4,RYR2,CAMK2D
6.507e-05	-9.64	regulation of response to stimulus	biological process	GO:0048583	4104	24	18204	50	GUCY1A2,CAMK2D,PRKACB,RXRA,NR4A2,SHOC2,PDE2A,PDE4B,CACNB4,PRKCA,SLC39A6,KALRN,TIAM2,PDE9A,PLCB1,ADCY8,GSK3B,RASGRF1,CBL,GARNL3,ITPR1,GUCY2F,MINK1,SMPDL3B
6.526e-05	-9.64	regulation of G protein-coupled receptor signaling pathway	biological process	GO:0008277	155	5	18204	50	PDE2A,PLCB1,PDE4B,GUCY2F,PRKCA
6.610e-05	-9.62	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	19	16828	47	CBL,GUCY1A2,DPEP1,KALRN,KCND2,RASGRF1,SLC18A2,PRKCA,GRIA3,CACNA1B,NBEA,PDE9A,ADCY8,PDE2A,PDE4B,PDE1A,PLCB1,RYR2,SYT10
6.668e-05	-9.62	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	12	16828	47	LRCH1,CACNA1B,CBL,ADCY8,KCND2,KALRN,PRKACB,CAMK2D,PDE1A,GUCY2F,PDE4B,PRKCA
6.668e-05	-9.62	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	12	16828	47	PDE4B,GUCY2F,PDE1A,CAMK2D,PRKACB,PRKCA,CBL,CACNA1B,LRCH1,KALRN,KCND2,ADCY8
6.775e-05	-9.60	cGMP-mediated signaling	biological process	GO:0019934	29	3	18204	50	GUCY2F,GUCY1A2,PDE2A
6.790e-05	-9.60	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	42	16828	47	RAPSN,GUCY2F,RASGRF1,PRKACB,SLC39A6,CAMK2D,KALRN,GUCY1A2,MRAS,KCND2,CELF3,PLCE1,PRKAR2A,RYR2,NR4A2,PDE4B,TIAM2,NPL,NBEA,ITPR1,GARNL3,PHACTR2,PRKCA,SHOC2,ATP2A1,PLD3,SMPDL3B,CBL,LRCH1,RAB37,PLCB1,CACNB4,SYT10,SLC16A14,RXRA,KCNH6,PDE1A,PDE2A,ADCY8,PDE9A,GRIA3,CACNA1B
7.021e-05	-9.56	Hemostasis	REACTOME pathways	R-HSA-109582	632	10	10285	38	ITPR1,PRKAR2A,GUCY1A2,ATP2A1,PDE9A,PRKACB,PDE1A,PDE2A,PRKCA,PHACTR2
7.057e-05	-9.56	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	35	16828	47	SLC18A2,SHOC2,PHACTR2,PRKCA,CBL,SMPDL3B,LRCH1,ATP2A1,PDE1A,KCNH6,CACNB4,PLCB1,RAB37,SYT10,RXRA,GRIA3,CACNA1B,ADCY8,PDE2A,PDE9A,GUCY2F,SLC39A6,CAMK2D,PRKACB,GUCY1A2,KALRN,DPEP1,KCND2,MRAS,PDE4B,TIAM2,PRKAR2A,RYR2,NR4A2,GARNL3
7.106e-05	-9.55	HNOB_dom_associated	interpro domains	IPR011645	5	2	18521	50	GUCY1A2,GUCY2F
7.169e-05	-9.54	Ras protein signal transduction	biological process	GO:0007265	81	4	18204	50	MRAS,SHOC2,RASGRF1,PLCE1
7.332e-05	-9.52	nucleotide metabolic process	biological process	GO:0009117	515	8	18204	50	ADCY8,GUCY1A2,CACNB4,GUCY2F,PDE2A,PDE4B,PDE1A,PDE9A
7.389e-05	-9.51	HNOBA	pfam domains	PF07701	5	2	17795	49	GUCY2F,GUCY1A2
7.680e-05	-9.47	regulation of blood circulation	biological process	GO:1903522	261	6	18204	50	KCND2,CAMK2D,RYR2,PDE4B,KCNH6,ATP2A1
8.113e-05	-9.42	response to nitrogen compound	biological process	GO:1901698	1021	11	18204	50	ADCY8,DPEP1,PLCB1,NR4A2,CACNA1B,GSK3B,ITPR1,SHOC2,PDE2A,SLC18A2,RYR2
8.164e-05	-9.41	nucleoside phosphate metabolic process	biological process	GO:0006753	523	8	18204	50	GUCY1A2,ADCY8,PDE9A,PDE1A,PDE4B,PDE2A,CACNB4,GUCY2F
8.255e-05	-9.40	TRPC3 (transient receptor potential cation channel subfamily C member 3)	protein interactions	7222	33	3	19454	50	ITPR1,PLCB1,PRKCA
8.288e-05	-9.40	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	18	16828	47	CAMK2D,GUCY2F,PRKCA,LRCH1,CBL,KCND2,GUCY1A2,KALRN,PDE1A,SYT10,RYR2,PLCB1,GARNL3,ITPR1,GRIA3,PDE2A,ADCY8,NBEA
8.694e-05	-9.35	mouth	COSMIC cancer mutations	mouth	9004	38	16828	47	GUCY1A2,DPEP1,KALRN,KCND2,RASGRF1,GUCY2F,PRKACB,FOXD3,GARNL3,RASD1,ITPR1,NBEA,PDE4B,TIAM2,PRKAR2A,RYR2,CELF3,PLCE1,NR4A2,CBL,SMPDL3B,LRCH1,ATP2A1,PLD3,SLC18A2,PHACTR2,PRKCA,GRIA3,CACNA1B,PDE2A,PDE9A,ADCY8,PDE1A,KCNH6,PLCB1,SLC16A14,SYT10,RXRA
9.143e-05	-9.30	ligand-gated ion channel signaling pathway	biological process	GO:1990806	32	3	18204	50	PLCB1,ITPR1,GRIA3
9.196e-05	-9.29	Muscle contraction	REACTOME pathways	R-HSA-397014	204	6	10285	38	RYR2,CAMK2D,ATP2A1,CACNB4,ITPR1,KCND2
9.203e-05	-9.29	ANXA7 (annexin A7)	protein interactions	310	178	5	19454	50	CBL,CELF3,TIAM2,PRKCA,PLD3
9.444e-05	-9.27	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	22	16828	47	LRCH1,CBL,SMPDL3B,KCND2,MRAS,GUCY1A2,KALRN,CAMK2D,RASGRF1,PRKCA,PHACTR2,CACNA1B,ITPR1,GRIA3,ADCY8,PDE9A,PDE1A,TIAM2,PDE4B,SYT10,RYR2,PLCB1
1.010e-04	-9.20	regulation of calcium ion transmembrane transport	biological process	GO:1903169	170	5	18204	50	ATP2A1,PDE4B,CAMK2D,RYR2,CACNB4
1.064e-04	-9.15	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	2	18521	50	RYR2,ITPR1
1.064e-04	-9.15	Ins145_P3_rcpt	interpro domains	IPR014821	6	2	18521	50	ITPR1,RYR2
1.064e-04	-9.15	RIH_assoc-dom	interpro domains	IPR013662	6	2	18521	50	RYR2,ITPR1
1.064e-04	-9.15	RIH_dom	interpro domains	IPR000699	6	2	18521	50	ITPR1,RYR2
1.064e-04	-9.15	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	2	18521	50	RYR2,ITPR1
1.101e-04	-9.11	regulation of relaxation of cardiac muscle	biological process	GO:1901897	6	2	18204	50	PDE4B,CAMK2D
1.106e-04	-9.11	RIH_assoc	pfam domains	PF08454	6	2	17795	49	RYR2,ITPR1
1.106e-04	-9.11	RYDR_ITPR	pfam domains	PF01365	6	2	17795	49	RYR2,ITPR1
1.106e-04	-9.11	Ins145_P3_rec	pfam domains	PF08709	6	2	17795	49	ITPR1,RYR2
1.122e-04	-9.10	AKAP11 (A-kinase anchoring protein 11)	protein interactions	11215	97	4	19454	50	PRKCA,PRKACB,PRKAR2A,GSK3B
1.149e-04	-9.07	PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha)	protein interactions	5573	300	6	19454	50	PRKCA,PRKACB,PRKAR2A,GSK3B,CAMK2D,CBL
1.155e-04	-9.07	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	19	16828	47	SLC18A2,RASGRF1,PRKCA,CBL,KCND2,DPEP1,KALRN,GUCY1A2,PDE1A,PDE4B,SYT10,RYR2,PLCB1,CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A,NBEA
1.178e-04	-9.05	purine ribonucleotide catabolic process	biological process	GO:0009154	92	4	18204	50	PDE4B,PDE2A,PDE9A,PDE1A
1.261e-04	-8.98	neuron projection	cellular component	GO:0043005	1331	12	19108	50	GRIA3,KCND2,CBL,GUCY2F,SLC18A2,GSK3B,CAMK2D,ADCY8,PDE4B,TIAM2,MINK1,RASGRF1
1.265e-04	-8.98	BHLHE41 (basic helix-loop-helix family member e41)	protein interactions	79365	38	3	19454	50	RXRA,GSK3B,RASD1
1.280e-04	-8.96	DARPP-32 events	REACTOME pathways	R-HSA-180024	27	3	10285	38	PDE4B,PRKACB,PRKAR2A
1.306e-04	-8.94	positive regulation of cardiac muscle hypertrophy	biological process	GO:0010613	36	3	18204	50	PDE9A,CAMK2D,PRKCA
1.348e-04	-8.91	Prkar2b (protein kinase, cAMP dependent regulatory, type II beta)	protein interactions	19088	7	2	19454	50	PRKAR2A,PRKACB
1.363e-04	-8.90	HP (haptoglobin)	protein interactions	3240	102	4	19454	50	NGB,GSK3B,PRKACB,PRKAR2A
1.414e-04	-8.86	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	33	16828	47	PHACTR2,PRKCA,SLC18A2,ATP2A1,PLD3,SMPDL3B,CBL,LRCH1,PLCB1,CACNB4,SYT10,RXRA,SLC16A14,KCNH6,PDE1A,ADCY8,GRIA3,CACNA1B,RAPSN,RASGRF1,PRKACB,KALRN,GUCY1A2,MRAS,KCND2,PLCE1,RYR2,NR4A2,PDE4B,TIAM2,NBEA,ITPR1,GARNL3
1.414e-04	-8.86	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	33	16828	47	SLC18A2,PHACTR2,PRKCA,SMPDL3B,CBL,LRCH1,ATP2A1,PLD3,KCNH6,PDE1A,PLCB1,CACNB4,SLC16A14,RXRA,SYT10,GRIA3,CACNA1B,ADCY8,RASGRF1,PRKACB,RAPSN,GUCY1A2,KALRN,MRAS,KCND2,PDE4B,TIAM2,PLCE1,RYR2,NR4A2,GARNL3,ITPR1,NBEA
1.418e-04	-8.86	positive regulation of muscle hypertrophy	biological process	GO:0014742	37	3	18204	50	PDE9A,CAMK2D,PRKCA
1.421e-04	-8.86	response to hypoxia	biological process	GO:0001666	292	6	18204	50	NR4A2,CBL,ITPR1,KCND2,NGB,RYR2
1.469e-04	-8.83	SPP1 (secreted phosphoprotein 1)	protein interactions	6696	104	4	19454	50	SLC39A6,PRKACB,PRKCA,PLD3
1.473e-04	-8.82	cyclic nucleotide binding	molecular function	GO:0030551	38	3	18094	49	PDE2A,PRKAR2A,PDE4B
1.483e-04	-8.82	transmembrane transporter activity	molecular function	GO:0022857	1110	11	18094	49	CACNA1B,KCNH6,ATP2A1,GRIA3,RYR2,KCND2,SLC18A2,SLC16A14,ITPR1,CACNB4,SLC39A6
1.499e-04	-8.81	regulation of system process	biological process	GO:0044057	571	8	18204	50	RYR2,PDE4B,PRKCA,PDE9A,CAMK2D,KCNH6,KCND2,ATP2A1
1.504e-04	-8.80	ribonucleotide catabolic process	biological process	GO:0009261	98	4	18204	50	PDE1A,PDE9A,PDE2A,PDE4B
1.532e-04	-8.78	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	33	16828	47	DPEP1,KALRN,GUCY1A2,KCND2,GUCY2F,CAMK2D,SLC39A6,GARNL3,PRKAR2A,RYR2,NR4A2,PDE4B,TIAM2,ATP2A1,CBL,SMPDL3B,LRCH1,PHACTR2,PRKCA,SHOC2,SLC18A2,PDE2A,PDE9A,ADCY8,GRIA3,CACNA1B,CACNB4,RAB37,PLCB1,RXRA,SYT10,PDE1A,KCNH6
1.539e-04	-8.78	regulation of ATPase-coupled calcium transmembrane transporter activity	biological process	GO:1901894	7	2	18204	50	ATP2A1,RYR2
1.543e-04	-8.78	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	13	18094	49	GSK3B,ADCY8,PRKACB,CACNA1B,PDE4B,GUCY2F,CAMK2D,PRKCA,KALRN,PRKAR2A,ATP2A1,PDE2A,MINK1
1.564e-04	-8.76	regulation of striated muscle contraction	biological process	GO:0006942	99	4	18204	50	CAMK2D,RYR2,PDE4B,ATP2A1
1.578e-04	-8.75	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	7	18204	50	RYR2,CAMK2D,ADCY8,CACNB4,ITPR1,SLC39A6,ATP2A1
1.603e-04	-8.74	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	2	14470	48	RYR2,ITPR1
1.604e-04	-8.74	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	42	16828	47	NPL,NBEA,GARNL3,ITPR1,NR4A2,PLCE1,CELF3,PRKAR2A,RYR2,TIAM2,PDE4B,MRAS,KCND2,KALRN,GUCY1A2,RAPSN,PRKACB,SLC39A6,CAMK2D,GUCY2F,RASGRF1,ADCY8,PDE2A,PDE9A,CACNA1B,GRIA3,SYT10,RXRA,SLC16A14,RAB37,PLCB1,CACNB4,KCNH6,PDE1A,PLD3,ATP2A1,LRCH1,SMPDL3B,CBL,PRKCA,PHACTR2,SHOC2
1.637e-04	-8.72	Platelet activation	KEGG pathways	hsa04611	123	5	7161	31	PRKACB,ITPR1,GUCY1A2,ADCY8,PLCB1
1.690e-04	-8.69	purine nucleotide catabolic process	biological process	GO:0006195	101	4	18204	50	PDE1A,PDE9A,PDE2A,PDE4B
1.694e-04	-8.68	inorganic ion homeostasis	biological process	GO:0098771	433	7	18204	50	ITPR1,CACNB4,ADCY8,SLC39A6,CAMK2D,RYR2,ATP2A1
1.709e-04	-8.67	RGS12 (regulator of G protein signaling 12)	protein interactions	6002	42	3	19454	50	NBEA,PLCB1,CACNA1B
1.709e-04	-8.67	postsynaptic density	cellular component	GO:0014069	317	6	19108	50	KALRN,GRIA3,ITPR1,MINK1,ADCY8,PDE4B
1.728e-04	-8.66	monoatomic ion channel activity	molecular function	GO:0005216	441	7	18094	49	RYR2,GRIA3,KCND2,CACNB4,KCNH6,ITPR1,CACNA1B
1.730e-04	-8.66	Ser/Thr_kinase_AS	interpro domains	IPR008271	308	6	18521	50	MINK1,PRKACB,KALRN,CAMK2D,GSK3B,PRKCA
1.793e-04	-8.63	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	7	18204	50	CAMK2D,RYR2,SLC39A6,CACNB4,ADCY8,ITPR1,ATP2A1
1.832e-04	-8.60	regulation of small GTPase mediated signal transduction	biological process	GO:0051056	306	6	18204	50	CBL,GARNL3,RASGRF1,KALRN,TIAM2,SHOC2
1.832e-04	-8.60	response to decreased oxygen levels	biological process	GO:0036293	306	6	18204	50	NR4A2,CBL,KCND2,ITPR1,NGB,RYR2
1.933e-04	-8.55	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	3	19108	50	ATP2A1,RYR2,CAMK2D
1.941e-04	-8.55	nucleobase-containing small molecule metabolic process	biological process	GO:0055086	593	8	18204	50	PDE1A,PDE9A,PDE2A,PDE4B,GUCY2F,CACNB4,GUCY1A2,ADCY8
1.947e-04	-8.54	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	13	16828	47	PHACTR2,CELF3,PLCB1,RYR2,CAMK2D,PDE1A,PDE4B,PDE2A,ADCY8,KCND2,GUCY1A2,KALRN,CBL
1.947e-04	-8.54	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	13	16828	47	CBL,KCND2,ADCY8,PDE2A,KALRN,GUCY1A2,PDE1A,CAMK2D,PDE4B,RYR2,PLCB1,CELF3,PHACTR2
1.991e-04	-8.52	guanylate cyclase activity	molecular function	GO:0004383	8	2	18094	49	GUCY1A2,GUCY2F
2.013e-04	-8.51	locomotory behavior	biological process	GO:0007626	197	5	18204	50	ADCY8,KCND2,CACNB4,SLC18A2,NR4A2
2.048e-04	-8.49	ion channel modulating, G protein-coupled receptor signaling pathway	biological process	GO:0099105	8	2	18204	50	PLCB1,ITPR1
2.048e-04	-8.49	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	biological process	GO:0007207	8	2	18204	50	ITPR1,PLCB1
2.068e-04	-8.48	phospholipase activity	molecular function	GO:0004620	108	4	18094	49	PLCE1,PLCB1,SMPDL3B,PLD3
2.110e-04	-8.46	purine-containing compound catabolic process	biological process	GO:0072523	107	4	18204	50	PDE9A,PDE1A,PDE4B,PDE2A
2.138e-04	-8.45	purine ribonucleoside triphosphate binding	molecular function	GO:0035639	1804	14	18094	49	MRAS,RASD1,RAB37,GSK3B,ADCY8,PRKACB,PRKCA,KALRN,ATP2A1,GUCY1A2,MINK1,CACNA1B,CAMK2D,GUCY2F
2.144e-04	-8.45	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME pathways	R-HSA-399721	32	3	10285	38	CAMK2D,GRIA3,PRKCA
2.144e-04	-8.45	Trafficking of AMPA receptors	REACTOME pathways	R-HSA-399719	32	3	10285	38	PRKCA,GRIA3,CAMK2D
2.214e-04	-8.42	voltage-gated calcium channel complex	cellular component	GO:0005891	45	3	19108	50	CACNB4,PDE4B,CACNA1B
2.231e-04	-8.41	asymmetric synapse	cellular component	GO:0032279	333	6	19108	50	GRIA3,KALRN,PDE4B,ADCY8,MINK1,ITPR1
2.232e-04	-8.41	response to organic substance	biological process	GO:0010033	2498	17	18204	50	PLCB1,ADCY8,GSK3B,LRCH1,CBL,CACNA1B,ITPR1,RXRA,NR4A2,PDE2A,SHOC2,MRAS,SLC18A2,RYR2,PDE4B,PRKCA,CACNB4
2.240e-04	-8.40	plasma membrane raft	cellular component	GO:0044853	114	4	19108	50	PRKAR2A,ADCY8,KCND2,CBL
2.243e-04	-8.40	AKAP7 (A-kinase anchoring protein 7)	protein interactions	9465	46	3	19454	50	PRKAR2A,PRKACB,PRKCA
2.304e-04	-8.38	SCTR (secretin receptor)	protein interactions	6344	9	2	19454	50	PRKAR2A,PRKCA
2.313e-04	-8.37	calmodulin binding	molecular function	GO:0005516	206	5	18094	49	PDE1A,ADCY8,CAMK2D,PLCB1,RYR2
2.352e-04	-8.36	Glucagon signaling in metabolic regulation	REACTOME pathways	R-HSA-163359	33	3	10285	38	PRKAR2A,ADCY8,PRKACB
2.388e-04	-8.34	cAMP-dependent protein kinase complex	cellular component	GO:0005952	9	2	19108	50	PRKAR2A,PRKACB
2.388e-04	-8.34	platelet dense tubular network membrane	cellular component	GO:0031095	9	2	19108	50	ITPR1,ATP2A1
2.431e-04	-8.32	mucosal	COSMIC cancer mutations	mucosal	2009	15	16828	47	NPL,GUCY1A2,DPEP1,ADCY8,PDE2A,PLD3,CBL,GARNL3,CELF3,PLCB1,NR4A2,SLC16A14,RXRA,SYT10,TIAM2
2.431e-04	-8.32	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	15	16828	47	ADCY8,PDE2A,PLD3,DPEP1,NPL,GUCY1A2,GARNL3,CBL,NR4A2,RXRA,SLC16A14,SYT10,PLCB1,CELF3,TIAM2
2.440e-04	-8.32	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	45	16828	47	CACNB4,PLCB1,SYT10,SLC16A14,RXRA,PDE1A,KCNH6,ADCY8,PDE2A,PDE9A,GRIA3,CACNA1B,PHACTR2,PRKCA,SHOC2,SLC18A2,ATP2A1,NGB,CBL,SMPDL3B,LRCH1,PRKAR2A,RYR2,PLCE1,CELF3,NR4A2,PDE4B,TIAM2,NBEA,NPL,GARNL3,ITPR1,RASD1,RAPSN,FOXD3,RASGRF1,GUCY2F,CAMK2D,SLC39A6,PRKACB,DPEP1,GUCY1A2,KALRN,KCND2,MRAS
2.547e-04	-8.28	MYH2 (myosin heavy chain 2)	protein interactions	4620	48	3	19454	50	PRKACB,PDE2A,CBL
2.552e-04	-8.27	regulation of membrane potential	biological process	GO:0042391	463	7	18204	50	GRIA3,CACNB4,KCND2,CAMK2D,RYR2,KCNH6,GSK3B
2.582e-04	-8.26	monoatomic cation channel activity	molecular function	GO:0005261	331	6	18094	49	ITPR1,CACNA1B,KCND2,RYR2,KCNH6,CACNB4
2.598e-04	-8.26	metal ion binding	molecular function	GO:0046872	4239	23	18094	49	NR4A2,CACNA1B,PDE1A,RYR2,PDE2A,ATP2A1,PLCB1,CBL,PLCE1,RAPSN,SMPDL3B,PDE4B,KCND2,SYT10,PDE9A,KALRN,PRKCA,RXRA,PRKACB,ADCY8,ITPR1,DPEP1,NGB
2.664e-04	-8.23	molecular function regulator activity	molecular function	GO:0098772	2079	15	18094	49	TIAM2,KALRN,SHOC2,PRKAR2A,CAMK2D,GARNL3,PHACTR2,RASGRF1,PDE4B,MRAS,PLCE1,NGB,PLCB1,DPEP1,ITPR1
2.692e-04	-8.22	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	23	16828	47	PHACTR2,PRKCA,RASGRF1,CAMK2D,GUCY1A2,KALRN,MRAS,KCND2,PLD3,SMPDL3B,CBL,LRCH1,PLCB1,RYR2,SYT10,PDE4B,PDE1A,TIAM2,PDE9A,ADCY8,GRIA3,ITPR1,CACNA1B
2.759e-04	-8.20	CREB phosphorylation through the activation of Adenylate Cyclase	REACTOME pathways	R-HSA-442720	7	2	10285	38	ADCY8,PRKACB
2.760e-04	-8.20	adenyl nucleotide binding	molecular function	GO:0030554	1620	13	18094	49	PDE4B,CACNA1B,CAMK2D,GUCY2F,PRKCA,KALRN,PRKAR2A,ATP2A1,PDE2A,MINK1,GSK3B,ADCY8,PRKACB
2.799e-04	-8.18	ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)	protein interactions	3708	123	4	19454	50	ATP2A1,RYR2,ITPR1,CAMK2D
2.811e-04	-8.18	calcium channel activity	molecular function	GO:0005262	117	4	18094	49	ITPR1,CACNA1B,RYR2,CACNB4
2.860e-04	-8.16	PRKCD (protein kinase C delta)	protein interactions	5580	227	5	19454	50	PLCB1,PRKCA,GSK3B,ITPR1,ATP2A1
2.863e-04	-8.16	Prot_kinase_dom	interpro domains	IPR000719	480	7	18521	50	PRKCA,CAMK2D,GSK3B,KALRN,PRKACB,MINK1,GUCY2F
2.875e-04	-8.15	TNP1 (transition protein 1)	protein interactions	7141	10	2	19454	50	PRKCA,PRKACB
2.903e-04	-8.14	regulation of long-term synaptic potentiation	biological process	GO:1900271	47	3	18204	50	GSK3B,PDE9A,ADCY8
2.952e-04	-8.13	regulation of monoatomic ion transmembrane transporter activity	biological process	GO:0032412	214	5	18204	50	MINK1,CACNB4,CAMK2D,RYR2,ATP2A1
2.963e-04	-8.12	skin-ankle-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-ankle-malignant_melanoma-acral_lentiginous	330	6	16828	47	CBL,PDE4B,ADCY8,GUCY1A2,PLCB1,KALRN
2.976e-04	-8.12	regulation of intracellular signal transduction	biological process	GO:1902531	1832	14	18204	50	CBL,GARNL3,RASGRF1,GSK3B,PRKACB,PLCB1,GUCY1A2,KALRN,TIAM2,PRKCA,ITPR1,MINK1,PDE2A,SHOC2
3.002e-04	-8.11	Cadmium Induces DNA Synthesis and Proliferation in Macrophages	SMPDB pathways	SMP0063805	20	3	1369	10	ITPR1,PLCB1,PRKCA
3.169e-04	-8.06	transporter activity	molecular function	GO:0005215	1211	11	18094	49	CACNB4,SLC39A6,ITPR1,SLC16A14,SLC18A2,KCNH6,ATP2A1,KCND2,RYR2,GRIA3,CACNA1B
3.170e-04	-8.06	MIR_motif	interpro domains	IPR016093	10	2	18521	50	ITPR1,RYR2
3.170e-04	-8.06	MIR_dom_sf	interpro domains	IPR036300	10	2	18521	50	ITPR1,RYR2
3.172e-04	-8.06	vif (Vif)	protein interactions	155459	362	6	19454	50	NR4A2,PDE9A,PRKACB,PRKAR2A,PLCB1,PHACTR2
3.250e-04	-8.03	regulation of transport	biological process	GO:0051049	1621	13	18204	50	SYT10,RYR2,PDE4B,ITPR1,CACNB4,MINK1,PLCB1,CAMK2D,ADCY8,ATP2A1,GSK3B,RXRA,CBL
3.296e-04	-8.02	MIR	pfam domains	PF02815	10	2	17795	49	ITPR1,RYR2
3.310e-04	-8.01	Wnt signaling pathway	KEGG pathways	ko04310	143	5	7161	31	PRKACB,PRKCA,PLCB1,GSK3B,CAMK2D
3.310e-04	-8.01	Wnt signaling pathway	KEGG pathways	hsa04310	143	5	7161	31	PLCB1,GSK3B,PRKCA,PRKACB,CAMK2D
3.324e-04	-8.01	GTPase regulator activity	molecular function	GO:0030695	491	7	18094	49	RASGRF1,GARNL3,PLCB1,KALRN,NGB,TIAM2,PLCE1
3.324e-04	-8.01	nucleoside-triphosphatase regulator activity	molecular function	GO:0060589	491	7	18094	49	PLCB1,GARNL3,RASGRF1,PLCE1,TIAM2,NGB,KALRN
3.460e-04	-7.97	regulation of signal transduction	biological process	GO:0009966	3114	19	18204	50	TIAM2,KALRN,PDE4B,SHOC2,PDE2A,PRKCA,RXRA,PRKACB,NR4A2,GUCY1A2,SMPDL3B,MINK1,ITPR1,GUCY2F,GSK3B,RASGRF1,GARNL3,CBL,PLCB1
3.495e-04	-7.96	regulation of transmembrane transporter activity	biological process	GO:0022898	222	5	18204	50	ATP2A1,RYR2,CAMK2D,MINK1,CACNB4
3.510e-04	-7.95	Ras signaling pathway	KEGG pathways	hsa04014	226	6	7161	31	PLCE1,PRKCA,PRKACB,SHOC2,RASGRF1,MRAS
3.631e-04	-7.92	Pkinase	pfam domains	PF00069	347	6	17795	49	CAMK2D,KALRN,PRKACB,MINK1,PRKCA,GSK3B
3.636e-04	-7.92	platelet dense tubular network	cellular component	GO:0031094	11	2	19108	50	ATP2A1,ITPR1
3.642e-04	-7.92	carbohydrate derivative catabolic process	biological process	GO:1901136	224	5	18204	50	PDE2A,PDE4B,PDE1A,NPL,PDE9A
3.646e-04	-7.92	neuron to neuron synapse	cellular component	GO:0098984	365	6	19108	50	KALRN,GRIA3,MINK1,ITPR1,ADCY8,PDE4B
3.707e-04	-7.90	action potential	biological process	GO:0001508	124	4	18204	50	KCND2,CACNB4,RYR2,KCNH6
3.707e-04	-7.90	nucleotide catabolic process	biological process	GO:0009166	124	4	18204	50	PDE4B,PDE2A,PDE9A,PDE1A
3.763e-04	-7.89	cation binding	molecular function	GO:0043169	4341	23	18094	49	PLCB1,CBL,PLCE1,RAPSN,PDE1A,CACNA1B,NR4A2,ATP2A1,PDE2A,RYR2,DPEP1,ITPR1,RXRA,PRKACB,ADCY8,NGB,PDE4B,SMPDL3B,PDE9A,KALRN,PRKCA,KCND2,SYT10
3.799e-04	-7.88	channel activity	molecular function	GO:0015267	502	7	18094	49	ITPR1,CACNA1B,KCND2,RYR2,GRIA3,KCNH6,CACNB4
3.803e-04	-7.87	plasma membrane region	cellular component	GO:0098590	1278	11	19108	50	AJM1,PDE2A,DPEP1,PDE9A,ADCY8,RAPSN,PRKAR2A,GRIA3,SLC39A6,KCND2,CBL
3.845e-04	-7.86	passive transmembrane transporter activity	molecular function	GO:0022803	503	7	18094	49	ITPR1,CACNA1B,KCNH6,CACNB4,KCND2,GRIA3,RYR2
3.975e-04	-7.83	protein kinase A binding	molecular function	GO:0051018	53	3	18094	49	GSK3B,PRKAR2A,RYR2
4.003e-04	-7.82	cGMP biosynthetic process	biological process	GO:0006182	11	2	18204	50	GUCY2F,GUCY1A2
4.003e-04	-7.82	cellular response to epinephrine stimulus	biological process	GO:0071872	11	2	18204	50	PDE4B,RYR2
4.058e-04	-7.81	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	40	16828	47	DPEP1,GUCY1A2,KALRN,KCND2,RAPSN,FOXD3,GUCY2F,RASGRF1,PRKACB,CAMK2D,SLC39A6,NPL,NBEA,ITPR1,PLCE1,CELF3,RYR2,PRKAR2A,NR4A2,PDE4B,TIAM2,ATP2A1,PLD3,NGB,SMPDL3B,CBL,PHACTR2,PRKCA,SHOC2,PDE9A,PDE2A,ADCY8,GRIA3,CACNA1B,PLCB1,CACNB4,SLC16A14,SYT10,KCNH6,PDE1A
4.058e-04	-7.81	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	40	16828	47	PLD3,NGB,ATP2A1,CBL,SMPDL3B,PRKCA,PHACTR2,SHOC2,PDE2A,ADCY8,PDE9A,CACNA1B,GRIA3,SYT10,SLC16A14,CACNB4,PLCB1,PDE1A,KCNH6,KCND2,DPEP1,KALRN,GUCY1A2,FOXD3,RAPSN,SLC39A6,CAMK2D,PRKACB,RASGRF1,GUCY2F,NBEA,NPL,ITPR1,NR4A2,PRKAR2A,RYR2,CELF3,PLCE1,TIAM2,PDE4B
4.163e-04	-7.78	protein serine kinase activity	molecular function	GO:0106310	362	6	18094	49	GSK3B,PRKACB,CAMK2D,PRKCA,KALRN,MINK1
4.261e-04	-7.76	HRAS (HRas proto-oncogene, GTPase)	protein interactions	3265	712	8	19454	50	SHOC2,PLD3,PLCB1,MINK1,RASGRF1,SLC39A6,PLCE1,CBL
4.288e-04	-7.75	positive regulation of transport	biological process	GO:0051050	844	9	18204	50	CBL,ATP2A1,GSK3B,RXRA,ADCY8,PLCB1,ITPR1,RYR2,SYT10
4.311e-04	-7.75	monoatomic cation homeostasis	biological process	GO:0055080	505	7	18204	50	ITPR1,ADCY8,CACNB4,SLC39A6,RYR2,CAMK2D,ATP2A1
4.311e-04	-7.75	cellular response to organonitrogen compound	biological process	GO:0071417	505	7	18204	50	ADCY8,RYR2,PLCB1,PDE2A,SHOC2,NR4A2,GSK3B
4.462e-04	-7.71	GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B)	protein interactions	2904	58	3	19454	50	PRKCA,RASGRF1,CAMK2D
4.556e-04	-7.69	ErbB signaling pathway	KEGG pathways	ko04012	85	4	7161	31	CAMK2D,CBL,PRKCA,GSK3B
4.556e-04	-7.69	ErbB signaling pathway	KEGG pathways	hsa04012	85	4	7161	31	CAMK2D,CBL,PRKCA,GSK3B
4.565e-04	-7.69	response to calcium ion	biological process	GO:0051592	131	4	18204	50	CAMK2D,RYR2,ADCY8,DPEP1
4.626e-04	-7.68	peptidyl-threonine phosphorylation	biological process	GO:0018107	55	3	18204	50	CAMK2D,PRKCA,GSK3B
4.633e-04	-7.68	PLC_EF-hand-like	interpro domains	IPR015359	12	2	18521	50	PLCB1,PLCE1
4.662e-04	-7.67	response to chemical	biological process	GO:0042221	3743	21	18204	50	RYR2,SLC18A2,PDE4B,PDE2A,SHOC2,MRAS,CACNB4,PRKCA,RXRA,NR4A2,CAMK2D,ITPR1,LRCH1,GSK3B,CBL,CACNA1B,NGB,PLCB1,KCND2,DPEP1,ADCY8
4.707e-04	-7.66	lipase activity	molecular function	GO:0016298	134	4	18094	49	PLD3,SMPDL3B,PLCB1,PLCE1
4.797e-04	-7.64	Kinase-like_dom_sf	interpro domains	IPR011009	523	7	18521	50	PRKACB,MINK1,GUCY2F,GSK3B,CAMK2D,KALRN,PRKCA
4.817e-04	-7.64	EF-hand_like	pfam domains	PF09279	12	2	17795	49	PLCE1,PLCB1
4.834e-04	-7.63	nucleoside phosphate catabolic process	biological process	GO:1901292	133	4	18204	50	PDE9A,PDE1A,PDE4B,PDE2A
4.848e-04	-7.63	monoatomic ion homeostasis	biological process	GO:0050801	515	7	18204	50	ATP2A1,CAMK2D,RYR2,ADCY8,ITPR1,CACNB4,SLC39A6
4.931e-04	-7.61	PEX16 (peroxisomal biogenesis factor 16)	protein interactions	9409	60	3	19454	50	ADCY8,ATP2A1,SLC18A2
4.931e-04	-7.61	ABCB8 (ATP binding cassette subfamily B member 8)	protein interactions	11194	60	3	19454	50	ATP2A1,SLC18A2,LRCH1
4.997e-04	-7.60	Signaling by GPCR	REACTOME pathways	R-HSA-372790	1299	13	10285	38	PDE1A,PDE2A,PRKCA,RASGRF1,PRKACB,KALRN,TIAM2,PLCB1,CAMK2D,PDE4B,ADCY8,ITPR1,PRKAR2A
5.004e-04	-7.60	Hedgehog 'off' state	REACTOME pathways	R-HSA-5610787	101	4	10285	38	PRKAR2A,GSK3B,PRKACB,ADCY8
5.100e-04	-7.58	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	6	18521	50	KALRN,CAMK2D,GSK3B,PRKCA,PRKACB,MINK1
5.177e-04	-7.57	GLB1L2 (galactosidase beta 1 like 2)	protein interactions	89944	61	3	19454	50	ATP2A1,GRIA3,PLD3
5.186e-04	-7.56	Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME pathways	R-HSA-432040	43	3	10285	38	PRKACB,ADCY8,PRKAR2A
5.200e-04	-7.56	GABAergic synapse	KEGG pathways	hsa04727	88	4	7161	31	ADCY8,PRKCA,PRKACB,CACNA1B
5.200e-04	-7.56	GABAergic synapse	KEGG pathways	ko04727	88	4	7161	31	PRKACB,PRKCA,ADCY8,CACNA1B
5.428e-04	-7.52	Dilated cardiomyopathy	KEGG pathways	hsa05414	89	4	7161	31	RYR2,CACNB4,PRKACB,ADCY8
5.428e-04	-7.52	Dilated cardiomyopathy	KEGG pathways	ko05414	89	4	7161	31	CACNB4,RYR2,ADCY8,PRKACB
5.629e-04	-7.48	MIR	prosite domains	PS50919	10	2	12186	44	RYR2,ITPR1
5.641e-04	-7.48	cellular response to organic substance	biological process	GO:0071310	1716	13	18204	50	PLCB1,ADCY8,GSK3B,RXRA,LRCH1,CBL,NR4A2,PDE2A,SHOC2,MRAS,RYR2,PDE4B,CACNB4
5.871e-04	-7.44	Acetylcholine regulates insulin secretion	REACTOME pathways	R-HSA-399997	10	2	10285	38	PRKCA,PLCB1
5.899e-04	-7.44	regulation of calcium ion transport	biological process	GO:0051924	249	5	18204	50	ATP2A1,CAMK2D,PDE4B,RYR2,CACNB4
5.957e-04	-7.43	C2_dom	interpro domains	IPR000008	143	4	18521	50	SYT10,PRKCA,PLCB1,PLCE1
5.988e-04	-7.42	enzyme regulator activity	molecular function	GO:0030234	1305	11	18094	49	DPEP1,PLCB1,NGB,PLCE1,PHACTR2,RASGRF1,GARNL3,PRKAR2A,KALRN,SHOC2,TIAM2
6.007e-04	-7.42	cellular response to peptide hormone stimulus	biological process	GO:0071375	250	5	18204	50	NR4A2,GSK3B,ADCY8,PLCB1,SHOC2
6.014e-04	-7.42	voltage-gated monoatomic cation channel activity	molecular function	GO:0022843	143	4	18094	49	CACNA1B,CACNB4,KCNH6,KCND2
6.107e-04	-7.40	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	7	19454	50	MINK1,ATP2A1,SLC39A6,PRKCA,DPEP1,PLD3,NBEA
6.403e-04	-7.35	high voltage-gated calcium channel activity	molecular function	GO:0008331	14	2	18094	49	CACNA1B,CACNB4
6.407e-04	-7.35	cGMP signaling	KEGG pathways	hsa_M00694	9	2	7161	31	PDE2A,GUCY1A2
6.407e-04	-7.35	cGMP signaling	KEGG pathways	M00694	9	2	7161	31	GUCY1A2,PDE2A
6.569e-04	-7.33	excitatory synapse	cellular component	GO:0060076	65	3	19108	50	ADCY8,PDE4B,GRIA3
6.580e-04	-7.33	presynapse	cellular component	GO:0098793	569	7	19108	50	PDE4B,ADCY8,PDE2A,CACNB4,SYT10,GSK3B,SLC18A2
6.588e-04	-7.33	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	GO:0106072	14	2	18204	50	PDE2A,PDE4B
6.588e-04	-7.33	regulation of relaxation of muscle	biological process	GO:1901077	14	2	18204	50	CAMK2D,PDE4B
6.588e-04	-7.33	response to epinephrine	biological process	GO:0071871	14	2	18204	50	RYR2,PDE4B
6.680e-04	-7.31	guanyl nucleotide binding	molecular function	GO:0019001	396	6	18094	49	PDE2A,GUCY1A2,MRAS,RASD1,RAB37,GUCY2F
6.680e-04	-7.31	guanyl ribonucleotide binding	molecular function	GO:0032561	396	6	18094	49	PDE2A,MRAS,GUCY1A2,RAB37,RASD1,GUCY2F
6.684e-04	-7.31	MAPK signaling pathway	KEGG pathways	hsa04010	255	6	7161	31	RASGRF1,MRAS,PRKACB,PRKCA,CACNA1B,CACNB4
6.684e-04	-7.31	MAPK signaling pathway	KEGG pathways	ko04010	255	6	7161	31	RASGRF1,MRAS,PRKCA,PRKACB,CACNA1B,CACNB4
6.904e-04	-7.28	glutamatergic synapse	cellular component	GO:0098978	412	6	19108	50	GSK3B,PLCB1,KCND2,SYT10,CACNB4,ADCY8
6.925e-04	-7.28	small GTPase-mediated signal transduction	biological process	GO:0007264	258	5	18204	50	PLCE1,TIAM2,RASGRF1,MRAS,SHOC2
6.979e-04	-7.27	response to abiotic stimulus	biological process	GO:0009628	1100	10	18204	50	CBL,NR4A2,KCND2,GUCY1A2,NGB,ITPR1,CACNB4,GUCY2F,PDE2A,RYR2
7.097e-04	-7.25	Phospholipase C Signaling Pathway	SMPDB pathways	SMP0063783	6	2	1369	10	PLCB1,PRKCA
7.118e-04	-7.25	AKAP5 (A-kinase anchoring protein 5)	protein interactions	9495	68	3	19454	50	PRKCA,PRKACB,PRKAR2A
7.137e-04	-7.25	cellular process	biological process	GO:0009987	14996	49	18204	50	KALRN,PDE9A,RAPSN,SHOC2,SLC18A2,CACNB4,PRKACB,RXRA,RAB37,GUCY1A2,CAMK2D,SLC16A14,NBEA,PDE1A,PLCE1,NPL,GUCY2F,ATP2A1,GSK3B,CELF3,LRCH1,RASD1,NGB,KCND2,DPEP1,ADCY8,TIAM2,PDE2A,MRAS,PDE4B,RYR2,PRKCA,SLC39A6,AJM1,NR4A2,PRKAR2A,KCNH6,PLD3,FOXD3,SYT10,ITPR1,MINK1,SMPDL3B,RASGRF1,CBL,CACNA1B,PLCB1,PHACTR2,GRIA3
7.333e-04	-7.22	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	2	18521	50	PLCB1,PLCE1
7.333e-04	-7.22	PI-PLC_fam	interpro domains	IPR001192	15	2	18521	50	PLCB1,PLCE1
7.333e-04	-7.22	CNH_dom	interpro domains	IPR001180	15	2	18521	50	GARNL3,MINK1
7.426e-04	-7.21	humerus	COSMIC cancer mutations	humerus	546	7	16828	47	KCND2,SYT10,ADCY8,RYR2,KALRN,CACNA1B,SLC18A2
7.478e-04	-7.20	regulation of molecular function	biological process	GO:0065009	2005	14	18204	50	TIAM2,MINK1,CACNB4,RYR2,CBL,LRCH1,RXRA,GSK3B,RASGRF1,ATP2A1,DPEP1,ADCY8,CAMK2D,PRKAR2A
7.519e-04	-7.19	Phosphatidylinositol signaling system	KEGG pathways	ko04070	97	4	7161	31	ITPR1,PRKCA,PLCE1,PLCB1
7.519e-04	-7.19	Phosphatidylinositol signaling system	KEGG pathways	hsa04070	97	4	7161	31	PLCB1,ITPR1,PRKCA,PLCE1
7.554e-04	-7.19	peptidyl-threonine modification	biological process	GO:0018210	65	3	18204	50	CAMK2D,PRKCA,GSK3B
7.588e-04	-7.18	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	2	18204	50	ATP2A1,RYR2
7.592e-04	-7.18	AKAP6 (A-kinase anchoring protein 6)	protein interactions	9472	16	2	19454	50	PRKAR2A,RYR2
7.623e-04	-7.18	PI-PLC-Y	pfam domains	PF00387	15	2	17795	49	PLCE1,PLCB1
7.623e-04	-7.18	CNH	pfam domains	PF00780	15	2	17795	49	MINK1,GARNL3
7.680e-04	-7.17	response to organonitrogen compound	biological process	GO:0010243	915	9	18204	50	ADCY8,PLCB1,NR4A2,CACNA1B,GSK3B,SLC18A2,RYR2,PDE2A,SHOC2
7.747e-04	-7.16	MICAL1 (microtubule associated monooxygenase, calponin and LIM domain containing 1)	protein interactions	64780	70	3	19454	50	RAB37,GSK3B,GUCY2F
7.796e-04	-7.16	response to oxygen-containing compound	biological process	GO:1901700	1546	12	18204	50	ADCY8,DPEP1,PLCB1,NR4A2,CACNA1B,CBL,RXRA,GSK3B,ITPR1,PDE4B,SHOC2,PDE2A
7.804e-04	-7.16	PROTEIN_KINASE_ST	prosite domains	PS00108	308	6	12186	44	PRKACB,GSK3B,KALRN,CAMK2D,PRKCA,MINK1
7.816e-04	-7.15	Estrogen signaling pathway	KEGG pathways	hsa04915	98	4	7161	31	PLCB1,PRKACB,ITPR1,ADCY8
7.816e-04	-7.15	Estrogen signaling pathway	KEGG pathways	ko04915	98	4	7161	31	ITPR1,PRKACB,ADCY8,PLCB1
7.860e-04	-7.15	system process	biological process	GO:0003008	2015	14	18204	50	CAMK2D,PLCB1,KCND2,ADCY8,ATP2A1,PRKACB,GSK3B,RASGRF1,SYT10,RYR2,PDE2A,CACNB4,GUCY2F,ITPR1
7.901e-04	-7.14	establishment of localization	biological process	GO:0051234	3887	21	18204	50	RYR2,SLC18A2,SHOC2,SLC39A6,CACNB4,KALRN,RAPSN,KCNH6,SLC16A14,RAB37,SYT10,ITPR1,PLCE1,NGB,PLCB1,KCND2,GRIA3,ATP2A1,GSK3B,CACNA1B,CBL
7.972e-04	-7.13	ankle	COSMIC cancer mutations	ankle	398	6	16828	47	ADCY8,KALRN,PLCB1,GUCY1A2,PDE4B,CBL
8.103e-04	-7.12	DLG4 (discs large MAGUK scaffold protein 4)	protein interactions	1742	163	4	19454	50	GUCY1A2,GRIA3,PRKCA,KCND2
8.346e-04	-7.09	miRs in Muscle Cell Differentiation	WikiPathways	WP2012	36	3	5310	28	PRKAR2A,PRKACB,PRKCA
8.349e-04	-7.09	transport	biological process	GO:0006810	3615	20	18204	50	ATP2A1,GSK3B,CBL,CACNA1B,PLCB1,NGB,GRIA3,KCND2,PLCE1,SYT10,ITPR1,RAB37,KCNH6,SLC16A14,KALRN,SHOC2,RYR2,SLC18A2,CACNB4,SLC39A6
8.381e-04	-7.08	regulation of localization	biological process	GO:0032879	2028	14	18204	50	SYT10,PDE4B,RYR2,MINK1,CACNB4,ITPR1,PLCE1,CAMK2D,PLCB1,ADCY8,RXRA,ATP2A1,GSK3B,CBL
8.382e-04	-7.08	calcium-mediated signaling	biological process	GO:0019722	154	4	18204	50	PLCE1,ITPR1,CAMK2D,RYR2
8.410e-04	-7.08	ZDHHC23 (zinc finger DHHC-type palmitoyltransferase 23)	protein interactions	254887	72	3	19454	50	PRKCA,SMPDL3B,RXRA
8.410e-04	-7.08	SEMG2 (semenogelin 2)	protein interactions	6407	72	3	19454	50	PRKAR2A,PRKCA,DPEP1
8.410e-04	-7.08	PPARGC1A (PPARG coactivator 1 alpha)	protein interactions	10891	72	3	19454	50	NR4A2,GSK3B,RXRA
8.415e-04	-7.08	adenylate cyclase activity	molecular function	GO:0004016	16	2	18094	49	ADCY8,GUCY2F
8.416e-04	-7.08	MIR	smart domains	SM00472	10	2	9717	43	ITPR1,RYR2
8.527e-04	-7.07	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	12	16828	47	ADCY8,PLD3,GARNL3,ITPR1,PRKCA,SYT10,PLCB1,RYR2,PRKAR2A,PDE1A,CAMK2D,RASGRF1
8.590e-04	-7.06	MFSD10 (major facilitator superfamily domain containing 10)	protein interactions	10227	17	2	19454	50	PLD3,PDE2A
8.590e-04	-7.06	MRAS (muscle RAS oncogene homolog)	protein interactions	22808	17	2	19454	50	MRAS,SHOC2
8.664e-04	-7.05	CALM1 (calmodulin 1)	protein interactions	801	607	7	19454	50	ITPR1,PDE1A,CBL,ADCY8,CAMK2D,RYR2,RXRA
8.683e-04	-7.05	protein kinase activity	molecular function	GO:0004672	577	7	18094	49	GSK3B,GUCY2F,PRKACB,CAMK2D,KALRN,PRKCA,MINK1
8.923e-04	-7.02	DH-domain	interpro domains	IPR000219	70	3	18521	50	TIAM2,RASGRF1,KALRN
8.988e-04	-7.01	plasma membrane protein complex	cellular component	GO:0098797	600	7	19108	50	PDE4B,PRKCA,CACNB4,GRIA3,CACNA1B,CBL,KCND2
8.992e-04	-7.01	regulation of cardiac muscle hypertrophy	biological process	GO:0010611	69	3	18204	50	PDE9A,CAMK2D,PRKCA
9.077e-04	-7.00	Aquaporin-mediated transport	REACTOME pathways	R-HSA-445717	52	3	10285	38	PRKACB,ADCY8,PRKAR2A
9.084e-04	-7.00	Glucagon signaling pathway	KEGG pathways	hsa04922	102	4	7161	31	CAMK2D,ITPR1,PRKACB,PLCB1
9.084e-04	-7.00	Glucagon signaling pathway	KEGG pathways	ko04922	102	4	7161	31	CAMK2D,ITPR1,PRKACB,PLCB1
9.108e-04	-7.00	HACD2 (3-hydroxyacyl-CoA dehydratase 2)	protein interactions	201562	74	3	19454	50	ADCY8,ATP2A1,SLC18A2
9.217e-04	-6.99	hydrolase activity, acting on ester bonds	molecular function	GO:0016788	761	8	18094	49	PLCB1,PLCE1,SMPDL3B,PDE4B,PLD3,PDE1A,PDE2A,PDE9A
9.299e-04	-6.98	DBL_dom_sf	interpro domains	IPR035899	71	3	18521	50	TIAM2,RASGRF1,KALRN
9.308e-04	-6.98	nef (Nef)	protein interactions	156110	802	8	19454	50	PRKACB,PRKAR2A,CBL,GSK3B,ADCY8,ITPR1,PRKCA,RXRA
9.376e-04	-6.97	cardiac conduction	biological process	GO:0061337	70	3	18204	50	KCNH6,RYR2,CAMK2D
9.429e-04	-6.97	membrane raft	cellular component	GO:0045121	290	5	19108	50	PRKAR2A,ADCY8,SLC39A6,KCND2,CBL
9.434e-04	-6.97	RhoGEF	pfam domains	PF00621	70	3	17795	49	KALRN,TIAM2,RASGRF1
9.466e-04	-6.96	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	2	18521	50	PLCB1,PLCE1
9.615e-04	-6.95	endomembrane system	cellular component	GO:0012505	4764	23	19108	50	MINK1,ITPR1,PHACTR2,ADCY8,PDE4B,RASD1,SYT10,RYR2,NBEA,PDE9A,PLCB1,PLD3,RAPSN,RAB37,PRKCA,CAMK2D,PLCE1,SLC39A6,CBL,GUCY2F,SLC18A2,PDE2A,ATP2A1
9.648e-04	-6.94	AKAP14 (A-kinase anchoring protein 14)	protein interactions	158798	18	2	19454	50	PRKACB,PRKAR2A
9.685e-04	-6.94	PRKACB (protein kinase cAMP-activated catalytic subunit beta)	protein interactions	5567	171	4	19454	50	RYR2,PRKAR2A,GSK3B,CBL
9.723e-04	-6.94	membrane microdomain	cellular component	GO:0098857	292	5	19108	50	PRKAR2A,ADCY8,KCND2,SLC39A6,CBL
9.839e-04	-6.92	PI-PLC-X	pfam domains	PF00388	17	2	17795	49	PLCB1,PLCE1
9.873e-04	-6.92	intracellular chemical homeostasis	biological process	GO:0055082	581	7	18204	50	ATP2A1,CAMK2D,RYR2,ADCY8,ITPR1,CACNB4,SLC39A6
1.000e-03	-6.91	protein serine/threonine kinase activity	molecular function	GO:0004674	428	6	18094	49	PRKCA,KALRN,MINK1,GSK3B,CAMK2D,PRKACB
1.011e-03	-6.90	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	REACTOME pathways	R-HSA-112308	13	2	10285	38	CACNA1B,CACNB4
1.018e-03	-6.89	cellular response to calcium ion	biological process	GO:0071277	72	3	18204	50	CAMK2D,DPEP1,ADCY8
1.018e-03	-6.89	regulation of muscle hypertrophy	biological process	GO:0014743	72	3	18204	50	CAMK2D,PRKCA,PDE9A
1.022e-03	-6.89	UBXN8 (UBX domain protein 8)	protein interactions	7993	77	3	19454	50	SLC18A2,PLD3,ATP2A1
1.047e-03	-6.86	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	ko04961	47	3	7161	31	PRKACB,PRKCA,PLCB1
1.047e-03	-6.86	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	hsa04961	47	3	7161	31	PRKCA,PRKACB,PLCB1
1.069e-03	-6.84	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	2	18094	49	ITPR1,RYR2
1.077e-03	-6.83	TRPV6 (transient receptor potential cation channel subfamily V member 6)	protein interactions	55503	19	2	19454	50	PDE9A,PRKCA
1.077e-03	-6.83	Cdk5rap2 (CDK5 regulatory subunit associated protein 2)	protein interactions	214444	19	2	19454	50	PRKAR2A,PRKACB
1.081e-03	-6.83	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	7	14470	48	GSK3B,GUCY2F,MINK1,PRKCA,KALRN,CAMK2D,PRKACB
1.088e-03	-6.82	dendrite	cellular component	GO:0030425	620	7	19108	50	ADCY8,PDE4B,MINK1,GRIA3,KCND2,SLC18A2,GSK3B
1.108e-03	-6.80	dendritic tree	cellular component	GO:0097447	622	7	19108	50	GRIA3,KCND2,GSK3B,SLC18A2,ADCY8,PDE4B,MINK1
1.145e-03	-6.77	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	31	16828	47	SYT10,RXRA,RYR2,PRKAR2A,PLCB1,PDE1A,TIAM2,PDE4B,PDE2A,PDE9A,ADCY8,NPL,CACNA1B,ITPR1,GRIA3,PRKCA,RAPSN,PHACTR2,SLC39A6,CAMK2D,SLC18A2,SHOC2,RASGRF1,GUCY2F,KCND2,MRAS,ATP2A1,KALRN,GUCY1A2,LRCH1,CBL
1.152e-03	-6.77	bounding membrane of organelle	cellular component	GO:0098588	2198	14	19108	50	PDE2A,ATP2A1,PLCE1,RAB37,PHACTR2,CAMK2D,ADCY8,ITPR1,PLD3,GRIA3,RYR2,SYT10,GUCY2F,SLC18A2
1.160e-03	-6.76	C2_domain_sf	interpro domains	IPR035892	171	4	18521	50	PLCE1,PLCB1,SYT10,PRKCA
1.171e-03	-6.75	voltage-gated monoatomic ion channel activity	molecular function	GO:0005244	171	4	18094	49	CACNA1B,KCND2,CACNB4,KCNH6
1.184e-03	-6.74	regulation of muscle contraction	biological process	GO:0006937	169	4	18204	50	ATP2A1,PDE4B,CAMK2D,RYR2
1.204e-03	-6.72	carbohydrate derivative metabolic process	biological process	GO:1901135	975	9	18204	50	PDE1A,NPL,PDE9A,GUCY2F,CACNB4,PDE2A,PDE4B,ADCY8,GUCY1A2
1.221e-03	-6.71	Pathways in cancer	KEGG pathways	hsa05200	395	7	7161	31	CBL,RXRA,ADCY8,PRKACB,PRKCA,PLCB1,GSK3B
1.223e-03	-6.71	voltage-gated channel activity	molecular function	GO:0022832	173	4	18094	49	KCND2,CACNB4,KCNH6,CACNA1B
1.227e-03	-6.70	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	biological process	GO:1902514	19	2	18204	50	CAMK2D,PDE4B
1.227e-03	-6.70	positive regulation of Ras protein signal transduction	biological process	GO:0046579	19	2	18204	50	RASGRF1,SHOC2
1.260e-03	-6.68	Regulation of RAC1 activity	Pathway Interaction DB	rac1_reg_pathway	39	3	2226	13	TIAM2,RASGRF1,KALRN
1.294e-03	-6.65	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	12	16828	47	GUCY2F,RYR2,PLCB1,CBL,CACNA1B,ITPR1,NBEA,GUCY1A2,KALRN,DPEP1,PDE2A,ADCY8
1.294e-03	-6.65	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	12	16828	47	CACNA1B,ITPR1,CBL,ADCY8,PDE2A,DPEP1,NBEA,GUCY1A2,KALRN,GUCY2F,RYR2,PLCB1
1.299e-03	-6.65	CNH	prosite domains	PS50219	15	2	12186	44	MINK1,GARNL3
1.299e-03	-6.65	PIPLC_Y_DOMAIN	prosite domains	PS50008	15	2	12186	44	PLCE1,PLCB1
1.302e-03	-6.64	RAS	prosite domains	PS51421	60	3	12186	44	MRAS,RASD1,RAB37
1.314e-03	-6.63	Tritoqualine H1-Antihistamine Action	SMPDB pathways	SMP0062895	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Quifenadine H1-Antihistamine Action	SMPDB pathways	SMP0060743	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Temelastine H1-Antihistamine Action	SMPDB pathways	SMP0062880	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Cyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058923	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Clemastine H1-Antihistamine Action	SMPDB pathways	SMP0058891	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Thenalidine H1-Antihistamine Action	SMPDB pathways	SMP0062894	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Dexbrompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057580	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Desloratadine H1-Antihistamine Action	SMPDB pathways	SMP0060201	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Triprolidine H1-Antihistamine Action	SMPDB pathways	SMP0057581	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Orphenadrine H1-Antihistamine Action	SMPDB pathways	SMP0058808	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Astemizole H1-Antihistamine Action	SMPDB pathways	SMP0059897	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Histapyrrodine H1-Antihistamine Action	SMPDB pathways	SMP0058732	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Phenbenzamine H1-Antihistamine Action	SMPDB pathways	SMP0059702	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Chloropyramine H1-Antihistamine Action	SMPDB pathways	SMP0057585	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Thenyldiamine H1-Antihistamine Action	SMPDB pathways	SMP0062624	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Azelastine H1-Antihistamine Action	SMPDB pathways	SMP0060741	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Oxomemazine H1-Antihistamine Action	SMPDB pathways	SMP0059738	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Levocetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059114	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Carbinoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058797	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Diphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058785	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Alcaftadine H1-Antihistamine Action	SMPDB pathways	SMP0062881	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Levocabastine H1-Antihistamine Action	SMPDB pathways	SMP0060224	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Rupatadine H1-Antihistamine Action	SMPDB pathways	SMP0060235	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Loratadine H1-Antihistamine Action	SMPDB pathways	SMP0060195	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Thiazinamium H1-Antihistamine Action	SMPDB pathways	SMP0060742	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Pyrrobutamine H1-Antihistamine Action	SMPDB pathways	SMP0062887	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Flunarizine H1-Antihistamine Action	SMPDB pathways	SMP0061047	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Ketotifen H1-Antihistamine Action	SMPDB pathways	SMP0059868	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Bamipine H1-Antihistamine Action	SMPDB pathways	SMP0062882	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Chlorphenamine H1-Antihistamine Action	SMPDB pathways	SMP0056661	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Antazoline H1-Antihistamine Action	SMPDB pathways	SMP0057584	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Latrepirdine H1-Antihistamine Action	SMPDB pathways	SMP0062623	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Chlorphenoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058903	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Doxepin H1-Antihistamine Action	SMPDB pathways	SMP0059872	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Histamine H1 Receptor Activation	SMPDB pathways	SMP0063452	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Lysophosphatidic Acid LPA3 Signalling	SMPDB pathways	SMP0063755	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Epinastine H1-Antihistamine Action	SMPDB pathways	SMP0061191	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Mizolastine H1-Antihistamine Action	SMPDB pathways	SMP0060230	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Bepotastine H1-Antihistamine Action	SMPDB pathways	SMP0060058	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Meclizine H1-Antihistamine Action	SMPDB pathways	SMP0058956	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Talastine H1-Antihistamine Action	SMPDB pathways	SMP0057586	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Pimethixene H1-Antihistamine Action	SMPDB pathways	SMP0062886	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Terfenadine H1-Antihistamine Action	SMPDB pathways	SMP0060208	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Bromodiphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058813	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Propiomazine H1-Antihistamine Action	SMPDB pathways	SMP0062625	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Olopatadine H1-Antihistamine Action	SMPDB pathways	SMP0060740	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Mequitazine H1-Antihistamine Action	SMPDB pathways	SMP0059720	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Dexchlorpheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056811	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Thonzylamine H1-Antihistamine Action	SMPDB pathways	SMP0058769	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Methdilazine H1-Antihistamine Action	SMPDB pathways	SMP0059730	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Betahistine H1-Antihistamine Action	SMPDB pathways	SMP0060744	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Oxatomide H1-Antihistamine Action	SMPDB pathways	SMP0059044	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Phenyltoloxamine H1-Antihistamine Action	SMPDB pathways	SMP0058916	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Azatadine H1-Antihistamine Action	SMPDB pathways	SMP0059865	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Diphenylpyraline H1-Antihistamine Action	SMPDB pathways	SMP0058908	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Cetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059058	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Alimemazine H1-Antihistamine Action	SMPDB pathways	SMP0059689	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Mebhydrolin H1-Antihistamine Action	SMPDB pathways	SMP0061052	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Doxylamine H1-Antihistamine Action	SMPDB pathways	SMP0058803	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Ebastine H1-Antihistamine Action	SMPDB pathways	SMP0060204	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Chlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058931	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Dimetindene H1-Antihistamine Action	SMPDB pathways	SMP0057582	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Tripelennamine H1-Antihistamine Action	SMPDB pathways	SMP0057587	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Embramine H1-Antihistamine Action	SMPDB pathways	SMP0062622	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Buclizine H1-Antihistamine Action	SMPDB pathways	SMP0058964	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Brompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057579	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Clocinizine H1-Antihistamine Action	SMPDB pathways	SMP0062788	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Phenindamine H1-Antihistamine Action	SMPDB pathways	SMP0061190	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Emedastine H1-Antihistamine Action	SMPDB pathways	SMP0061040	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Isothipendyl H1-Antihistamine Action	SMPDB pathways	SMP0059716	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Cinnarizine H1-Antihistamine Action	SMPDB pathways	SMP0059110	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Fenethazine H1-Antihistamine Action	SMPDB pathways	SMP0059707	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Tolpropamine H1-Antihistamine Action	SMPDB pathways	SMP0062621	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Bilastine H1-Antihistamine Action	SMPDB pathways	SMP0060170	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Acrivastine H1-Antihistamine Action	SMPDB pathways	SMP0059881	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Hydroxyzine H1-Antihistamine Action	SMPDB pathways	SMP0058936	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Promethazine H1-Antihistamine Action	SMPDB pathways	SMP0059211	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Mirtazapine H1-Antihistamine Action	SMPDB pathways	SMP0062885	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Homochlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0062795	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Cyproheptadine H1-Antihistamine Action	SMPDB pathways	SMP0059694	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Fexofenadine H1-Antihistamine Action	SMPDB pathways	SMP0060218	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Quetiapine H1-Antihistamine Action	SMPDB pathways	SMP0062884	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Pheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056662	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Mepyramine H1-Antihistamine Action	SMPDB pathways	SMP0057583	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Deptropine H1-Antihistamine Action	SMPDB pathways	SMP0062883	8	2	1369	10	PLCB1,ITPR1
1.314e-03	-6.63	Methapyrilene H1-Antihistamine Action	SMPDB pathways	SMP0058741	8	2	1369	10	ITPR1,PLCB1
1.314e-03	-6.63	Hydroxyethylpromethazine H1-Antihistamine Action	SMPDB pathways	SMP0059710	8	2	1369	10	PLCB1,ITPR1
1.315e-03	-6.63	ORC5 (origin recognition complex subunit 5)	protein interactions	5001	84	3	19454	50	ATP2A1,DPEP1,SLC18A2
1.318e-03	-6.63	SHC4 (SHC adaptor protein 4)	protein interactions	399694	21	2	19454	50	NBEA,CBL
1.360e-03	-6.60	CREM (cAMP responsive element modulator)	protein interactions	1390	85	3	19454	50	GSK3B,CAMK2D,PRKCA
1.361e-03	-6.60	nitric oxide mediated signal transduction	biological process	GO:0007263	20	2	18204	50	GUCY1A2,RASD1
1.372e-03	-6.59	membrane protein complex	cellular component	GO:0098796	1261	10	19108	50	ATP2A1,CACNA1B,CACNB4,CBL,KCND2,GRIA3,KCNH6,RYR2,PDE4B,PRKCA
1.386e-03	-6.58	ITGB1 (integrin subunit beta 1)	protein interactions	3688	322	5	19454	50	ATP2A1,GSK3B,PLD3,RXRA,PRKCA
1.425e-03	-6.55	behavior	biological process	GO:0007610	619	7	18204	50	SLC18A2,PLCB1,KCND2,ADCY8,CACNB4,RASGRF1,NR4A2
1.429e-03	-6.55	axon	cellular component	GO:0030424	650	7	19108	50	SLC18A2,GSK3B,CBL,RASGRF1,MINK1,TIAM2,ADCY8
1.445e-03	-6.54	Ca2+ pathway	REACTOME pathways	R-HSA-4086398	61	3	10285	38	PRKCA,PLCB1,ITPR1
1.447e-03	-6.54	CERS1 (ceramide synthase 1)	protein interactions	10715	22	2	19454	50	ATP2A1,PLD3
1.452e-03	-6.54	GDS_CDC24_CS	interpro domains	IPR001331	21	2	18521	50	TIAM2,RASGRF1
1.495e-03	-6.51	regulation of biological process	biological process	GO:0050789	12079	43	18204	50	NR4A2,PRKAR2A,KCNH6,TIAM2,PDE2A,MRAS,PDE4B,RYR2,PRKCA,SLC39A6,RASGRF1,CBL,CACNA1B,GARNL3,PLCB1,GRIA3,PLD3,FOXD3,SYT10,ITPR1,MINK1,SMPDL3B,PRKACB,RXRA,GUCY1A2,CAMK2D,KALRN,PDE9A,RAPSN,SHOC2,SLC18A2,CACNB4,CELF3,GSK3B,ATP2A1,LRCH1,RASD1,KCND2,DPEP1,ADCY8,PLCE1,PDE1A,GUCY2F
1.495e-03	-6.51	regulation of biological quality	biological process	GO:0065008	2936	17	18204	50	PRKCA,CACNB4,PDE2A,RYR2,SLC18A2,RAPSN,PDE9A,KCNH6,CAMK2D,PRKACB,ITPR1,KCND2,GRIA3,ADCY8,PLCB1,GSK3B,RASGRF1
1.501e-03	-6.50	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	11	16828	47	RASGRF1,CAMK2D,PDE1A,PRKAR2A,RYR2,PLCB1,PRKCA,SYT10,ITPR1,PLD3,ADCY8
1.502e-03	-6.50	negative regulation of calcium-mediated signaling	biological process	GO:0050849	21	2	18204	50	GSK3B,ITPR1
1.502e-03	-6.50	G protein-coupled acetylcholine receptor signaling pathway	biological process	GO:0007213	21	2	18204	50	PLCB1,ITPR1
1.503e-03	-6.50	CST6 (cystatin E/M)	protein interactions	1474	88	3	19454	50	GSK3B,ATP2A1,SMPDL3B
1.503e-03	-6.50	CCNL2 (cyclin L2)	protein interactions	81669	88	3	19454	50	SMPDL3B,PRKCA,PRKACB
1.523e-03	-6.49	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	7	12186	44	PRKACB,GSK3B,KALRN,GUCY2F,PRKCA,CAMK2D,MINK1
1.544e-03	-6.47	Regulation of KIT signaling	REACTOME pathways	R-HSA-1433559	16	2	10285	38	PRKCA,CBL
1.547e-03	-6.47	regulation of monoatomic cation transmembrane transport	biological process	GO:1904062	309	5	18204	50	ATP2A1,CACNB4,CAMK2D,PDE4B,RYR2
1.596e-03	-6.44	ligand-gated monoatomic ion channel activity	molecular function	GO:0015276	186	4	18094	49	ITPR1,GRIA3,RYR2,KCNH6
1.608e-03	-6.43	Signaling by Hedgehog	REACTOME pathways	R-HSA-5358351	138	4	10285	38	GSK3B,PRKAR2A,PRKACB,ADCY8
1.628e-03	-6.42	ligand-gated channel activity	molecular function	GO:0022834	187	4	18094	49	ITPR1,KCNH6,RYR2,GRIA3
1.632e-03	-6.42	cellular response to organic cyclic compound	biological process	GO:0071407	464	6	18204	50	GSK3B,RXRA,ADCY8,PDE2A,PLCB1,RYR2
1.649e-03	-6.41	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	biological process	GO:0010881	22	2	18204	50	CAMK2D,RYR2
1.649e-03	-6.41	detection of light stimulus involved in sensory perception	biological process	GO:0050962	22	2	18204	50	GUCY2F,CACNB4
1.649e-03	-6.41	detection of light stimulus involved in visual perception	biological process	GO:0050908	22	2	18204	50	CACNB4,GUCY2F
1.649e-03	-6.41	positive regulation of long-term synaptic potentiation	biological process	GO:1900273	22	2	18204	50	ADCY8,PDE9A
1.663e-03	-6.40	Oocyte meiosis	KEGG pathways	ko04114	120	4	7161	31	CAMK2D,ITPR1,PRKACB,ADCY8
1.663e-03	-6.40	Oocyte meiosis	KEGG pathways	hsa04114	120	4	7161	31	CAMK2D,ADCY8,PRKACB,ITPR1
1.667e-03	-6.40	neuronal cell body	cellular component	GO:0043025	489	6	19108	50	ADCY8,TIAM2,PDE9A,CACNA1B,PDE1A,KCND2
1.671e-03	-6.39	C2	prosite domains	PS50004	142	4	12186	44	PRKCA,SYT10,PLCE1,PLCB1
1.671e-03	-6.39	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	3	14470	48	RASGRF1,KALRN,TIAM2
1.674e-03	-6.39	PIPLC_X_DOMAIN	prosite domains	PS50007	17	2	12186	44	PLCE1,PLCB1
1.683e-03	-6.39	CNH	smart domains	SM00036	14	2	9717	43	GARNL3,MINK1
1.683e-03	-6.39	Nitric Oxide Signaling Pathway	SMPDB pathways	SMP0063777	9	2	1369	10	PRKACB,PRKCA
1.683e-03	-6.39	Lysophosphatidic Acid LPA1 Signalling	SMPDB pathways	SMP0063746	9	2	1369	10	ITPR1,PLCB1
1.683e-03	-6.39	Lysophosphatidic Acid LPA2 Signalling	SMPDB pathways	SMP0063753	9	2	1369	10	PLCB1,ITPR1
1.700e-03	-6.38	positive regulation of insulin secretion	biological process	GO:0032024	86	3	18204	50	ITPR1,ADCY8,PLCB1
1.708e-03	-6.37	LEMD2 (LEM domain nuclear envelope protein 2)	protein interactions	221496	92	3	19454	50	PLD3,ADCY8,ATP2A1
1.713e-03	-6.37	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	7	19454	50	PLD3,SHOC2,PLCB1,PLCE1,SLC39A6,MINK1,CBL
1.713e-03	-6.37	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	22	16828	47	LRCH1,CBL,ATP2A1,GUCY1A2,KALRN,RASGRF1,PHACTR2,CACNA1B,GARNL3,ITPR1,GRIA3,ADCY8,NBEA,PDE1A,TIAM2,KCNH6,PDE4B,SYT10,SLC16A14,RXRA,CACNB4,RYR2
1.713e-03	-6.37	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	22	16828	47	CACNA1B,GARNL3,ITPR1,GRIA3,ADCY8,NBEA,TIAM2,PDE1A,KCNH6,PDE4B,SYT10,SLC16A14,RXRA,CACNB4,RYR2,LRCH1,CBL,ATP2A1,GUCY1A2,KALRN,RASGRF1,PHACTR2
1.723e-03	-6.36	GBA2 (glucosylceramidase beta 2)	protein interactions	57704	24	2	19454	50	ATP2A1,DPEP1
1.746e-03	-6.35	Trafficking of GluR2-containing AMPA receptors	REACTOME pathways	R-HSA-416993	17	2	10285	38	GRIA3,PRKCA
1.746e-03	-6.35	Unblocking of NMDA receptor, glutamate binding and activation	REACTOME pathways	R-HSA-438066	17	2	10285	38	CAMK2D,GRIA3
1.749e-03	-6.35	C2 domain	gene3d domains	2.60.40.150	156	4	14470	48	PLCE1,SYT10,PLCB1,PRKCA
1.803e-03	-6.32	phosphatidylinositol-mediated signaling	biological process	GO:0048015	23	2	18204	50	PLCB1,PLCE1
1.803e-03	-6.32	relaxation of muscle	biological process	GO:0090075	23	2	18204	50	ATP2A1,CAMK2D
1.818e-03	-6.31	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	21	16828	47	NR4A2,RXRA,PLCB1,PLCE1,KCNH6,TIAM2,PDE4B,PDE2A,ADCY8,RASD1,GARNL3,PRKCA,SHOC2,GUCY2F,RASGRF1,KCND2,DPEP1,KALRN,ATP2A1,SMPDL3B,CBL
1.824e-03	-6.31	response to cytokine	biological process	GO:0034097	834	8	18204	50	CBL,GSK3B,LRCH1,PLCB1,PRKCA,CACNB4,MRAS,PDE2A
1.870e-03	-6.28	RIMS1 (regulating synaptic membrane exocytosis 1)	protein interactions	22999	25	2	19454	50	RAB37,CACNA1B
1.875e-03	-6.28	post-embryonic development	biological process	GO:0009791	89	3	18204	50	ITPR1,SLC18A2,NR4A2
1.886e-03	-6.27	Rap1 signaling pathway	KEGG pathways	hsa04015	210	5	7161	31	MRAS,PLCE1,ADCY8,PRKCA,PLCB1
1.886e-03	-6.27	Rap1 signaling pathway	KEGG pathways	ko04015	210	5	7161	31	PLCB1,PLCE1,ADCY8,PRKCA,MRAS
1.898e-03	-6.27	PLC-like_Pdiesterase_TIM-brl	interpro domains	IPR017946	24	2	18521	50	PLCB1,PLCE1
1.913e-03	-6.26	human chr3q21.1-q21.2	chromosome location	human chr3q21.1-q21.2	1	1	26134	50	KALRN
1.913e-03	-6.26	human chr13q14.13-q14.2	chromosome location	human chr13q14.13-q14.2	1	1	26134	50	LRCH1
1.913e-03	-6.26	human chrXq22.3-q23	chromosome location	human chrXq22.3-q23	1	1	26134	50	GUCY2F
1.913e-03	-6.26	human chr6q25.2-q25.3	chromosome location	human chr6q25.2-q25.3	1	1	26134	50	TIAM2
1.936e-03	-6.25	PLCYc	smart domains	SM00149	15	2	9717	43	PLCE1,PLCB1
1.973e-03	-6.23	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	9	18204	50	ITPR1,SHOC2,PDE2A,PDE4B,ADCY8,DPEP1,PLCB1,NR4A2,GSK3B
1.977e-03	-6.23	G alpha (s) signalling events	REACTOME pathways	R-HSA-418555	146	4	10285	38	PDE1A,PDE4B,PDE2A,ADCY8
1.993e-03	-6.22	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	14	16828	47	KCND2,ADCY8,NBEA,GUCY1A2,NPL,CACNA1B,RASD1,GRIA3,PRKAR2A,CACNB4,RYR2,PLCB1,CAMK2D,SLC18A2
1.993e-03	-6.22	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	14	16828	47	GRIA3,CACNA1B,RASD1,NBEA,NPL,GUCY1A2,KCND2,ADCY8,CAMK2D,SLC18A2,RYR2,CACNB4,PRKAR2A,PLCB1
2.000e-03	-6.21	C2	smart domains	SM00239	122	4	9717	43	PLCE1,PRKCA,SYT10,PLCB1
2.023e-03	-6.20	PDE4A (phosphodiesterase 4A)	protein interactions	5141	26	2	19454	50	PRKAR2A,CAMK2D
2.031e-03	-6.20	DH_2	prosite domains	PS50010	70	3	12186	44	TIAM2,KALRN,RASGRF1
2.041e-03	-6.19	regulation of transmembrane transport	biological process	GO:0034762	485	6	18204	50	CACNB4,MINK1,PDE4B,RYR2,CAMK2D,ATP2A1
2.042e-03	-6.19	Signal Transduction	REACTOME pathways	R-HSA-162582	2547	18	10285	38	PRKAR2A,ADCY8,PDE4B,TIAM2,RASGRF1,PRKACB,PRKCA,RXRA,ITPR1,CAMK2D,ATP2A1,PLCB1,GSK3B,KALRN,CBL,PDE2A,GUCY2F,PDE1A
2.043e-03	-6.19	lyase activity	molecular function	GO:0016829	199	4	18094	49	NPL,ADCY8,GUCY2F,GUCY1A2
2.049e-03	-6.19	localization	biological process	GO:0051179	4474	22	18204	50	NBEA,PLCE1,SYT10,ITPR1,ATP2A1,GSK3B,CBL,CACNA1B,PLCB1,NGB,KCND2,GRIA3,KALRN,RAPSN,SHOC2,RYR2,SLC18A2,CACNB4,SLC39A6,RAB37,KCNH6,SLC16A14
2.062e-03	-6.18	positive regulation of transporter activity	biological process	GO:0032411	92	3	18204	50	ATP2A1,RXRA,RYR2
2.075e-03	-6.18	bone	COSMIC cancer mutations	bone	8157	33	16828	47	ATP2A1,PLD3,SMPDL3B,CBL,LRCH1,SLC18A2,ADCY8,GRIA3,CACNA1B,PLCB1,RAB37,SYT10,SLC16A14,KCNH6,PDE1A,DPEP1,GUCY1A2,KALRN,KCND2,FOXD3,GUCY2F,RASGRF1,PRKACB,SLC39A6,NPL,ITPR1,GARNL3,RASD1,PLCE1,PRKAR2A,RYR2,PDE4B,TIAM2
2.096e-03	-6.17	cAMP signaling	KEGG pathways	hsa_M00695	16	2	7161	31	ADCY8,PRKACB
2.096e-03	-6.17	cAMP signaling	KEGG pathways	M00695	16	2	7161	31	PRKACB,ADCY8
2.096e-03	-6.17	Lysophosphatidic Acid LPA4 Signalling	SMPDB pathways	SMP0063756	10	2	1369	10	PLCB1,ITPR1
2.096e-03	-6.17	Lysophosphatidic Acid LPA5 Signalling	SMPDB pathways	SMP0063757	10	2	1369	10	PLCB1,ITPR1
2.107e-03	-6.16	PRKACG (protein kinase cAMP-activated catalytic subunit gamma)	protein interactions	5568	99	3	19454	50	PRKAR2A,RYR2,PRKACB
2.155e-03	-6.14	ovary	COSMIC cancer mutations	ovary	14770	47	16828	47	LRCH1,CBL,SMPDL3B,PLD3,NGB,ATP2A1,SHOC2,SLC18A2,PRKCA,PHACTR2,CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A,PDE1A,KCNH6,SLC16A14,SYT10,RXRA,CACNB4,PLCB1,RAB37,KCND2,MRAS,DPEP1,GUCY1A2,KALRN,SLC39A6,CAMK2D,PRKACB,RASGRF1,GUCY2F,FOXD3,RAPSN,ITPR1,GARNL3,RASD1,NPL,NBEA,TIAM2,PDE4B,NR4A2,RYR2,PRKAR2A,PLCE1,CELF3
2.165e-03	-6.14	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	14	16828	47	CACNB4,RYR2,PRKAR2A,PLCB1,CAMK2D,SLC18A2,GUCY1A2,NPL,NBEA,KCND2,ADCY8,GRIA3,CACNA1B,RASD1
2.168e-03	-6.13	ANXA6 (annexin A6)	protein interactions	309	100	3	19454	50	SHOC2,PDE4B,PRKCA
2.176e-03	-6.13	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	47	16828	47	RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,RAPSN,FOXD3,DPEP1,GUCY1A2,KALRN,KCND2,MRAS,PDE4B,TIAM2,PRKAR2A,RYR2,CELF3,PLCE1,NR4A2,GARNL3,ITPR1,RASD1,NPL,NBEA,SLC18A2,SHOC2,PHACTR2,PRKCA,CBL,SMPDL3B,LRCH1,ATP2A1,PLD3,NGB,PDE1A,KCNH6,CACNB4,RAB37,PLCB1,RXRA,SYT10,SLC16A14,GRIA3,CACNA1B,PDE9A,PDE2A,ADCY8
2.176e-03	-6.13	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	47	16828	47	RAPSN,FOXD3,GUCY2F,RASGRF1,PRKACB,SLC39A6,CAMK2D,DPEP1,KALRN,GUCY1A2,MRAS,KCND2,CELF3,PLCE1,PRKAR2A,RYR2,NR4A2,PDE4B,TIAM2,NPL,NBEA,ITPR1,GARNL3,RASD1,PHACTR2,PRKCA,SHOC2,SLC18A2,ATP2A1,PLD3,NGB,SMPDL3B,CBL,LRCH1,PLCB1,RAB37,CACNB4,SLC16A14,RXRA,SYT10,KCNH6,PDE1A,ADCY8,PDE2A,PDE9A,GRIA3,CACNA1B
2.176e-03	-6.13	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	47	16828	47	GUCY1A2,DPEP1,KALRN,KCND2,MRAS,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,RAPSN,FOXD3,GARNL3,ITPR1,RASD1,NPL,NBEA,PDE4B,TIAM2,RYR2,PRKAR2A,PLCE1,CELF3,NR4A2,CBL,SMPDL3B,LRCH1,ATP2A1,NGB,PLD3,SLC18A2,SHOC2,PHACTR2,PRKCA,GRIA3,CACNA1B,PDE2A,ADCY8,PDE9A,PDE1A,KCNH6,CACNB4,RAB37,PLCB1,RXRA,SYT10,SLC16A14
2.176e-03	-6.13	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	47	16828	47	PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,FOXD3,RAPSN,MRAS,KCND2,KALRN,GUCY1A2,DPEP1,TIAM2,PDE4B,NR4A2,CELF3,PLCE1,RYR2,PRKAR2A,RASD1,GARNL3,ITPR1,NPL,NBEA,SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,SMPDL3B,CBL,NGB,PLD3,ATP2A1,KCNH6,PDE1A,SLC16A14,SYT10,RXRA,PLCB1,RAB37,CACNB4,CACNA1B,GRIA3,PDE9A,PDE2A,ADCY8
2.181e-03	-6.13	SLA (Src like adaptor)	protein interactions	6503	27	2	19454	50	CBL,GSK3B
2.181e-03	-6.13	TUBD1 (tubulin delta 1)	protein interactions	51174	27	2	19454	50	SMPDL3B,PRKCA
2.183e-03	-6.13	classic	COSMIC cancer mutations	classic	14774	47	16828	47	DPEP1,GUCY1A2,KALRN,KCND2,MRAS,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,RAPSN,FOXD3,ITPR1,RASD1,GARNL3,NPL,NBEA,PDE4B,TIAM2,RYR2,PRKAR2A,CELF3,PLCE1,NR4A2,CBL,SMPDL3B,LRCH1,ATP2A1,NGB,PLD3,SLC18A2,SHOC2,PHACTR2,PRKCA,GRIA3,CACNA1B,ADCY8,PDE2A,PDE9A,PDE1A,KCNH6,CACNB4,RAB37,PLCB1,SYT10,SLC16A14,RXRA
2.185e-03	-6.13	Ras activation uopn Ca2+ infux through NMDA receptor	REACTOME pathways	R-HSA-442982	19	2	10285	38	CAMK2D,RASGRF1
2.200e-03	-6.12	EZR (ezrin)	protein interactions	7430	526	6	19454	50	NBEA,PRKCA,PRKAR2A,SLC39A6,MINK1,CBL
2.200e-03	-6.12	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	6	12186	44	GSK3B,KALRN,PRKACB,MINK1,CAMK2D,PRKCA
2.211e-03	-6.11	medulla	COSMIC cancer mutations	medulla	14778	47	16828	47	PDE1A,KCNH6,SYT10,SLC16A14,RXRA,CACNB4,RAB37,PLCB1,CACNA1B,GRIA3,PDE9A,ADCY8,PDE2A,SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,CBL,SMPDL3B,PLD3,NGB,ATP2A1,TIAM2,PDE4B,NR4A2,PRKAR2A,RYR2,PLCE1,CELF3,RASD1,ITPR1,GARNL3,NBEA,NPL,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,FOXD3,RAPSN,KCND2,MRAS,DPEP1,KALRN,GUCY1A2
2.218e-03	-6.11	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	47	16828	47	KCNH6,PDE1A,SYT10,SLC16A14,RXRA,PLCB1,RAB37,CACNB4,CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A,SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,SMPDL3B,CBL,PLD3,NGB,ATP2A1,TIAM2,PDE4B,NR4A2,CELF3,PLCE1,RYR2,PRKAR2A,ITPR1,GARNL3,RASD1,NPL,NBEA,PRKACB,SLC39A6,CAMK2D,GUCY2F,RASGRF1,FOXD3,RAPSN,MRAS,KCND2,GUCY1A2,KALRN,DPEP1
2.240e-03	-6.10	phosphatidylinositol phospholipase C activity	molecular function	GO:0004435	26	2	18094	49	PLCE1,PLCB1
2.289e-03	-6.08	calcium ion binding	molecular function	GO:0005509	683	7	18094	49	ITPR1,CACNA1B,PLCB1,CBL,ATP2A1,SYT10,RYR2
2.294e-03	-6.08	PRAF2 (PRA1 domain family member 2)	protein interactions	11230	102	3	19454	50	DPEP1,PDE2A,ATP2A1
2.304e-03	-6.07	regulation of the force of heart contraction	biological process	GO:0002026	26	2	18204	50	RYR2,CAMK2D
2.304e-03	-6.07	negative regulation of neural precursor cell proliferation	biological process	GO:2000178	26	2	18204	50	PDE9A,SHOC2
2.304e-03	-6.07	membrane repolarization	biological process	GO:0086009	26	2	18204	50	KCNH6,KCND2
2.328e-03	-6.06	regulation of muscle adaptation	biological process	GO:0043502	96	3	18204	50	PDE9A,PRKCA,CAMK2D
2.345e-03	-6.06	Mapre1 (microtubule-associated protein, RP/EB family, member 1)	protein interactions	13589	28	2	19454	50	PRKAR2A,PRKACB
2.345e-03	-6.06	ADAP1 (ArfGAP with dual PH domains 1)	protein interactions	11033	28	2	19454	50	PRKCA,GSK3B
2.345e-03	-6.06	MAP10 (microtubule associated protein 10)	protein interactions	54627	28	2	19454	50	CAMK2D,PRKACB
2.345e-03	-6.06	CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3)	protein interactions	784	28	2	19454	50	CACNB4,CACNA1B
2.346e-03	-6.06	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	7	18094	49	MINK1,PRKCA,KALRN,CAMK2D,GUCY2F,PRKACB,GSK3B
2.354e-03	-6.05	non_seminoma	COSMIC cancer mutations	non_seminoma	492	6	16828	47	PRKCA,GUCY2F,CBL,PRKACB,CAMK2D,CACNA1B
2.371e-03	-6.04	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	47	16828	47	MRAS,KCND2,DPEP1,GUCY1A2,KALRN,PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,FOXD3,RAPSN,GARNL3,RASD1,ITPR1,NBEA,NPL,TIAM2,PDE4B,NR4A2,PLCE1,CELF3,RYR2,PRKAR2A,LRCH1,SMPDL3B,CBL,NGB,PLD3,ATP2A1,SHOC2,SLC18A2,PRKCA,PHACTR2,CACNA1B,GRIA3,PDE2A,ADCY8,PDE9A,KCNH6,PDE1A,RXRA,SYT10,SLC16A14,RAB37,PLCB1,CACNB4
2.371e-03	-6.04	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	47	16828	47	RXRA,SYT10,SLC16A14,PLCB1,RAB37,CACNB4,KCNH6,PDE1A,ADCY8,PDE9A,PDE2A,CACNA1B,GRIA3,PRKCA,PHACTR2,SLC18A2,SHOC2,NGB,PLD3,ATP2A1,LRCH1,SMPDL3B,CBL,NR4A2,PLCE1,CELF3,RYR2,PRKAR2A,TIAM2,PDE4B,NPL,NBEA,GARNL3,ITPR1,RASD1,FOXD3,RAPSN,PRKACB,SLC39A6,CAMK2D,GUCY2F,RASGRF1,MRAS,KCND2,DPEP1,GUCY1A2,KALRN
2.398e-03	-6.03	DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5)	protein interactions	80331	365	5	19454	50	PLD3,SLC18A2,SLC39A6,PRKAR2A,MINK1
2.401e-03	-6.03	PHPHLIPASEC	prints domains	PR00390	15	2	5227	26	PLCB1,PLCE1
2.417e-03	-6.03	catalytic activity	molecular function	GO:0003824	5569	25	18094	49	GSK3B,PLCB1,CBL,PLCE1,RASD1,PLD3,PDE1A,GUCY2F,ATP2A1,MINK1,PDE2A,GUCY1A2,DPEP1,NPL,PRKACB,ADCY8,NGB,RAB37,MRAS,PDE4B,SMPDL3B,CAMK2D,PDE9A,PRKCA,KALRN
2.424e-03	-6.02	GRK2 (G protein-coupled receptor kinase 2)	protein interactions	156	104	3	19454	50	PLCB1,PRKCA,RASGRF1
2.449e-03	-6.01	protein phosphorylation	biological process	GO:0006468	503	6	18204	50	GSK3B,PRKACB,KALRN,CAMK2D,PRKCA,MINK1
2.474e-03	-6.00	cellular response to hormone stimulus	biological process	GO:0032870	504	6	18204	50	PLCB1,SHOC2,ADCY8,GSK3B,RXRA,NR4A2
2.484e-03	-6.00	regulation of cardiac muscle contraction by calcium ion signaling	biological process	GO:0010882	27	2	18204	50	CAMK2D,RYR2
2.494e-03	-5.99	PLCXc	smart domains	SM00148	17	2	9717	43	PLCB1,PLCE1
2.552e-03	-5.97	Activation of cAMP-dependent protein kinase- PKA	SMPDB pathways	SMP0063764	11	2	1369	10	PRKAR2A,PRKACB
2.552e-03	-5.97	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	35	16828	47	SHOC2,PHACTR2,PRKCA,CBL,LRCH1,ATP2A1,PDE1A,RAB37,PLCB1,CACNB4,SYT10,RXRA,CACNA1B,ADCY8,PDE9A,PDE2A,GUCY2F,RASGRF1,PRKACB,SLC39A6,CAMK2D,GUCY1A2,KALRN,MRAS,KCND2,PDE4B,TIAM2,CELF3,RYR2,PRKAR2A,NR4A2,RASD1,ITPR1,GARNL3,NBEA
2.562e-03	-5.97	DH_1	prosite domains	PS00741	21	2	12186	44	TIAM2,RASGRF1
2.565e-03	-5.97	regulation of monoatomic ion transmembrane transport	biological process	GO:0034765	347	5	18204	50	ATP2A1,RYR2,PDE4B,CAMK2D,CACNB4
2.570e-03	-5.96	H2-Aa (histocompatibility 2, class II antigen A, alpha)	protein interactions	14960	1	1	19454	50	GSK3B
2.570e-03	-5.96	Dok3 (docking protein 3)	protein interactions	27261	1	1	19454	50	CBL
2.570e-03	-5.96	MTR10 (Mtr10p)	protein interactions	854331	1	1	19454	50	CAMK2D
2.570e-03	-5.96	BET4 (Rab geranylgeranyltransferase BET4)	protein interactions	853421	1	1	19454	50	PDE9A
2.570e-03	-5.96	fbxw7.L (F-box and WD repeat domain containing 7 L homeolog)	protein interactions	734230	1	1	19454	50	PRKCA
2.570e-03	-5.96	TAS2R20 (taste 2 receptor member 20)	protein interactions	259295	1	1	19454	50	PRKCA
2.570e-03	-5.96	Parp1 (poly (ADP-ribose) polymerase 1)	protein interactions	25591	1	1	19454	50	RXRA
2.570e-03	-5.96	axl-1 (Axin-like protein 1)	protein interactions	186869	1	1	19454	50	GSK3B
2.570e-03	-5.96	pparg.L (peroxisome proliferator activated receptor gamma L homeolog)	protein interactions	397769	1	1	19454	50	RXRA
2.570e-03	-5.96	Homer2 (homer scaffold protein 2)	protein interactions	29547	1	1	19454	50	ITPR1
2.570e-03	-5.96	GPR39 (G protein-coupled receptor 39)	protein interactions	2863	1	1	19454	50	GSK3B
2.570e-03	-5.96	Pdgfra (platelet derived growth factor receptor, alpha polypeptide)	protein interactions	18595	1	1	19454	50	CBL
2.570e-03	-5.96	Rims3 (regulating synaptic membrane exocytosis 3)	protein interactions	242662	1	1	19454	50	CACNB4
2.570e-03	-5.96	pry-1 (Axin-like protein pry-1)	protein interactions	173287	1	1	19454	50	GSK3B
2.570e-03	-5.96	US6 (envelope glycoprotein D)	protein interactions	2703444	1	1	19454	50	CBL
2.604e-03	-5.95	neuronal cell body membrane	cellular component	GO:0032809	29	2	19108	50	KCND2,ADCY8
2.615e-03	-5.95	cellular homeostasis	biological process	GO:0019725	689	7	18204	50	ATP2A1,SLC39A6,CACNB4,ITPR1,ADCY8,CAMK2D,RYR2
2.670e-03	-5.93	regulation of cardiac conduction	biological process	GO:1903779	28	2	18204	50	RYR2,ATP2A1
2.690e-03	-5.92	TNP2 (transition protein 2)	protein interactions	7142	30	2	19454	50	PRKACB,PRKCA
2.700e-03	-5.91	PLC-epsilon1_RA2	interpro domains	IPR028398	1	1	18521	50	PLCE1
2.700e-03	-5.91	NR4A2	interpro domains	IPR003073	1	1	18521	50	NR4A2
2.700e-03	-5.91	PLC-beta1_EF	interpro domains	IPR028400	1	1	18521	50	PLCB1
2.700e-03	-5.91	PLC_epsilon1_EF	interpro domains	IPR046974	1	1	18521	50	PLCE1
2.700e-03	-5.91	VDCC_N_a1su	interpro domains	IPR005447	1	1	18521	50	CACNA1B
2.700e-03	-5.91	Postsynaptic_CS	interpro domains	IPR018293	1	1	18521	50	RAPSN
2.700e-03	-5.91	Rapsyn_myristoylation/link_N	interpro domains	IPR019568	1	1	18521	50	RAPSN
2.700e-03	-5.91	K_chnl_volt-dep_Kv4	interpro domains	IPR004055	1	1	18521	50	KCND2
2.700e-03	-5.91	Postsynaptic	interpro domains	IPR001237	1	1	18521	50	RAPSN
2.700e-03	-5.91	FH_FOXD3	interpro domains	IPR047392	1	1	18521	50	FOXD3
2.700e-03	-5.91	Apical_junction	interpro domains	IPR038825	1	1	18521	50	AJM1
2.700e-03	-5.91	cPKC_alpha	interpro domains	IPR034663	1	1	18521	50	PRKCA
2.700e-03	-5.91	PLC-epsilon1_cat	interpro domains	IPR046973	1	1	18521	50	PLCE1
2.700e-03	-5.91	NanA	interpro domains	IPR005264	1	1	18521	50	NPL
2.708e-03	-5.91	inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels	molecular function	GO:0098695	1	1	18094	49	ITPR1
2.735e-03	-5.90	large_cell	COSMIC cancer mutations	large_cell	14845	47	16828	47	PRKCA,PHACTR2,SHOC2,SLC18A2,PLD3,NGB,ATP2A1,LRCH1,SMPDL3B,CBL,SLC16A14,SYT10,RXRA,PLCB1,RAB37,CACNB4,KCNH6,PDE1A,PDE9A,PDE2A,ADCY8,CACNA1B,GRIA3,FOXD3,RAPSN,PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,MRAS,KCND2,KALRN,GUCY1A2,DPEP1,NR4A2,CELF3,PLCE1,RYR2,PRKAR2A,TIAM2,PDE4B,NPL,NBEA,RASD1,GARNL3,ITPR1
2.747e-03	-5.90	positive regulation of CD24 production	biological process	GO:2000560	1	1	18204	50	PLCB1
2.747e-03	-5.90	regulation of microtubule anchoring at centrosome	biological process	GO:0150101	1	1	18204	50	GSK3B
2.747e-03	-5.90	lactam catabolic process	biological process	GO:0072340	1	1	18204	50	DPEP1
2.747e-03	-5.90	response to glyceraldehyde	biological process	GO:1905630	1	1	18204	50	PLCB1
2.747e-03	-5.90	sequestering of neurotransmitter	biological process	GO:0042137	1	1	18204	50	SLC18A2
2.747e-03	-5.90	positive regulation of angiotensin-activated signaling pathway	biological process	GO:0110063	1	1	18204	50	PRKCA
2.747e-03	-5.90	regulation of CD24 production	biological process	GO:2000559	1	1	18204	50	PLCB1
2.747e-03	-5.90	positive regulation of cardiac muscle cell contraction	biological process	GO:0106134	1	1	18204	50	ATP2A1
2.747e-03	-5.90	cellular response to glyceraldehyde	biological process	GO:1905631	1	1	18204	50	PLCB1
2.747e-03	-5.90	somato-dendritic dopamine secretion	biological process	GO:0099123	1	1	18204	50	SLC18A2
2.747e-03	-5.90	antibiotic metabolic process	biological process	GO:0016999	1	1	18204	50	DPEP1
2.747e-03	-5.90	maintenance of mitochondrion location	biological process	GO:0051659	1	1	18204	50	ATP2A1
2.747e-03	-5.90	serotonin secretion by mast cell	biological process	GO:0002552	1	1	18204	50	SLC18A2
2.754e-03	-5.89	TPR_MalT	pfam domains	PF17874	1	1	17795	49	RAPSN
2.754e-03	-5.89	Rapsyn_N	pfam domains	PF10579	1	1	17795	49	RAPSN
2.772e-03	-5.89	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	28	16828	47	CBL,ATP2A1,KALRN,GUCY1A2,KCND2,MRAS,RASGRF1,GUCY2F,PRKACB,RAPSN,PRKCA,GRIA3,CACNA1B,GARNL3,ITPR1,NBEA,NPL,ADCY8,PDE2A,TIAM2,PDE1A,KCNH6,RYR2,PLCE1,PLCB1,RXRA,SLC16A14,NR4A2
2.774e-03	-5.89	Insulin signaling pathway	KEGG pathways	hsa04910	138	4	7161	31	PRKAR2A,CBL,PRKACB,GSK3B
2.774e-03	-5.89	Insulin signaling pathway	KEGG pathways	ko04910	138	4	7161	31	GSK3B,PRKACB,CBL,PRKAR2A
2.784e-03	-5.88	phospholipase C activity	molecular function	GO:0004629	29	2	18094	49	PLCE1,PLCB1
2.784e-03	-5.88	ligand-gated calcium channel activity	molecular function	GO:0099604	29	2	18094	49	RYR2,ITPR1
2.786e-03	-5.88	positive regulation of cell communication	biological process	GO:0010647	1792	12	18204	50	ADCY8,GUCY1A2,PLCB1,CBL,RXRA,RASGRF1,MINK1,PRKCA,ITPR1,SHOC2,PDE9A,RAPSN
2.812e-03	-5.87	positive regulation of signaling	biological process	GO:0023056	1794	12	18204	50	RXRA,RASGRF1,CBL,PLCB1,GUCY1A2,ADCY8,RAPSN,PDE9A,SHOC2,MINK1,ITPR1,PRKCA
2.830e-03	-5.87	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	8	10285	38	PRKACB,PRKAR2A,ADCY8,CAMK2D,SLC39A6,ATP2A1,SLC18A2,RYR2
2.839e-03	-5.86	Phosphatidylinositol (PI) phosphodiesterase	gene3d domains	3.20.20.190	24	2	14470	48	PLCE1,PLCB1
2.842e-03	-5.86	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	3	19454	50	PRKCA,CBL,PLCE1
2.843e-03	-5.86	regulation of heart rate	biological process	GO:0002027	103	3	18204	50	CAMK2D,KCNH6,RYR2
2.863e-03	-5.86	mast cell degranulation	biological process	GO:0043303	29	2	18204	50	SLC18A2,CBL
2.863e-03	-5.86	mast cell activation involved in immune response	biological process	GO:0002279	29	2	18204	50	CBL,SLC18A2
2.863e-03	-5.86	regulation of cardiac muscle cell action potential	biological process	GO:0098901	29	2	18204	50	RYR2,CAMK2D
2.865e-03	-5.86	perinuclear region of cytoplasm	cellular component	GO:0048471	735	7	19108	50	RASD1,CBL,PDE2A,PDE9A,ITPR1,PRKCA,PDE4B
2.870e-03	-5.85	AVPR1B (arginine vasopressin receptor 1B)	protein interactions	553	31	2	19454	50	MINK1,PRKCA
2.876e-03	-5.85	RasGEF	pfam domains	PF00617	29	2	17795	49	RASGRF1,PLCE1
2.887e-03	-5.85	cytosol	cellular component	GO:0005829	5475	24	19108	50	PDE9A,PLCB1,RASGRF1,NPL,PRKACB,MINK1,TIAM2,PDE4B,SHOC2,NBEA,CACNB4,PDE2A,GUCY1A2,RXRA,PDE1A,KALRN,PRKAR2A,RAPSN,PLCE1,CAMK2D,PRKCA,GSK3B,CBL,NGB
2.900e-03	-5.84	regulation of cellular process	biological process	GO:0050794	11468	41	18204	50	PDE1A,PLCE1,GUCY2F,LRCH1,ATP2A1,GSK3B,CELF3,RASD1,ADCY8,DPEP1,KALRN,RAPSN,PDE9A,SLC18A2,SHOC2,CACNB4,RXRA,PRKACB,CAMK2D,GUCY1A2,PLD3,FOXD3,SYT10,MINK1,SMPDL3B,ITPR1,RASGRF1,CACNA1B,CBL,GARNL3,PLCB1,GRIA3,TIAM2,RYR2,PDE4B,MRAS,PDE2A,SLC39A6,PRKCA,NR4A2,PRKAR2A
2.937e-03	-5.83	phospholipases	BIOCYC pathways	HUMAN_LIPASYN-PWY	29	2	902	3	PLD3,PLCE1
2.951e-03	-5.83	enzyme binding	molecular function	GO:0019899	2086	13	18094	49	CACNB4,PLCE1,GSK3B,NBEA,PRKACB,PLCB1,RXRA,CBL,ADCY8,PRKAR2A,SHOC2,PRKCA,RYR2
2.961e-03	-5.82	Ras_GEF_dom_sf	interpro domains	IPR023578	30	2	18521	50	PLCE1,RASGRF1
2.961e-03	-5.82	RASGEF_cat_dom	interpro domains	IPR001895	30	2	18521	50	PLCE1,RASGRF1
2.961e-03	-5.82	RASGEF_cat_dom_sf	interpro domains	IPR036964	30	2	18521	50	RASGRF1,PLCE1
3.023e-03	-5.80	organonitrogen compound catabolic process	biological process	GO:1901565	1115	9	18204	50	DPEP1,GSK3B,CBL,PDE4B,PDE2A,SMPDL3B,PDE9A,NPL,PDE1A
3.044e-03	-5.79	regulation of synaptic plasticity	biological process	GO:0048167	219	4	18204	50	ADCY8,PDE9A,RASGRF1,GSK3B
3.057e-03	-5.79	FKBP1B (FKBP prolyl isomerase 1B)	protein interactions	2281	32	2	19454	50	RYR2,CAMK2D
3.057e-03	-5.79	GRIA4 (glutamate ionotropic receptor AMPA type subunit 4)	protein interactions	2893	32	2	19454	50	PRKCA,GRIA3
3.080e-03	-5.78	Endothelins	Pathway Interaction DB	endothelinpathway	53	3	2226	13	PRKCA,PLCB1,ADCY8
3.083e-03	-5.78	regulation of postsynaptic membrane potential	biological process	GO:0060078	106	3	18204	50	GSK3B,KCND2,GRIA3
3.166e-03	-5.76	cell body membrane	cellular component	GO:0044298	32	2	19108	50	ADCY8,KCND2
3.166e-03	-5.76	T cell receptor signaling pathway	biological process	GO:0050852	107	3	18204	50	PDE4B,SLC39A6,CACNB4
3.168e-03	-5.75	cell body	cellular component	GO:0044297	556	6	19108	50	KCND2,PDE1A,CACNA1B,PDE9A,TIAM2,ADCY8
3.176e-03	-5.75	Cardiac Hypertrophic Response	WikiPathways	WP2795	57	3	5310	28	CAMK2D,PRKCA,GSK3B
3.177e-03	-5.75	intracellularly ligand-gated monoatomic ion channel activity	molecular function	GO:0005217	31	2	18094	49	ITPR1,RYR2
3.221e-03	-5.74	chemical homeostasis	biological process	GO:0048878	914	8	18204	50	RYR2,CACNB4,ITPR1,SLC39A6,ATP2A1,PRKACB,CAMK2D,ADCY8
3.249e-03	-5.73	SNCAIP (synuclein alpha interacting protein)	protein interactions	9627	33	2	19454	50	KALRN,GSK3B
3.267e-03	-5.72	positive regulation of calcium ion transmembrane transporter activity	biological process	GO:1901021	31	2	18204	50	ATP2A1,RYR2
3.267e-03	-5.72	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0010880	31	2	18204	50	CAMK2D,RYR2
3.312e-03	-5.71	RhoGEF	smart domains	SM00325	68	3	9717	43	TIAM2,KALRN,RASGRF1
3.317e-03	-5.71	Phospholipase D signaling pathway	KEGG pathways	ko04072	145	4	7161	31	MRAS,PLCB1,ADCY8,PRKCA
3.317e-03	-5.71	Phospholipase D signaling pathway	KEGG pathways	hsa04072	145	4	7161	31	PLCB1,PRKCA,ADCY8,MRAS
3.321e-03	-5.71	GTP binding	molecular function	GO:0005525	374	5	18094	49	GUCY1A2,MRAS,RAB37,RASD1,GUCY2F
3.338e-03	-5.70	guanyl-nucleotide exchange factor activity	molecular function	GO:0005085	228	4	18094	49	TIAM2,PLCE1,KALRN,RASGRF1
3.342e-03	-5.70	pleura	COSMIC cancer mutations	pleura	4914	23	16828	47	PDE1A,RYR2,PRKAR2A,PLCB1,RAB37,PLCE1,RASD1,ITPR1,GRIA3,PDE2A,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,PRKCA,FOXD3,CBL,KCND2,PLD3,MRAS,ATP2A1,KALRN
3.367e-03	-5.69	PRKCA (protein kinase C alpha)	protein interactions	5578	395	5	19454	50	PLCB1,PRKCA,CBL,GSK3B,PRKAR2A
3.385e-03	-5.69	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	4	19454	50	GSK3B,CBL,GUCY1A2,SHOC2
3.404e-03	-5.68	cellular response to endogenous stimulus	biological process	GO:0071495	1135	9	18204	50	GSK3B,RXRA,NR4A2,CBL,PLCB1,ADCY8,SHOC2,PDE2A,RYR2
3.423e-03	-5.68	phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	GO:0007200	110	3	18204	50	PLCB1,ITPR1,PLCE1
3.441e-03	-5.67	Bile secretion	KEGG pathways	hsa04976	71	3	7161	31	RXRA,PRKACB,ADCY8
3.441e-03	-5.67	Bile secretion	KEGG pathways	ko04976	71	3	7161	31	RXRA,PRKACB,ADCY8
3.446e-03	-5.67	TUBA4B (tubulin alpha 4b)	protein interactions	80086	34	2	19454	50	CBL,NGB
3.461e-03	-5.67	response to endoplasmic reticulum stress	biological process	GO:0034976	227	4	18204	50	GSK3B,ATP2A1,RASGRF1,ITPR1
3.479e-03	-5.66	mast cell mediated immunity	biological process	GO:0002448	32	2	18204	50	CBL,SLC18A2
3.487e-03	-5.66	GNAI2 (G protein subunit alpha i2)	protein interactions	2771	243	4	19454	50	CBL,RASD1,SLC39A6,NGB
3.495e-03	-5.66	cNMP_binding	pfam domains	PF00027	32	2	17795	49	PRKAR2A,KCNH6
3.511e-03	-5.65	positive regulation of peptide hormone secretion	biological process	GO:0090277	111	3	18204	50	PLCB1,ADCY8,ITPR1
3.532e-03	-5.65	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	6	16828	47	SLC18A2,CACNA1B,SMPDL3B,ADCY8,KCND2,PLCB1
3.533e-03	-5.65	Axon guidance	REACTOME pathways	R-HSA-422475	549	7	10285	38	CACNB4,RASGRF1,PRKACB,KALRN,GSK3B,CAMK2D,PRKCA
3.548e-03	-5.64	ITGB4 (integrin subunit beta 4)	protein interactions	3691	119	3	19454	50	RXRA,PRKCA,CBL
3.551e-03	-5.64	kinase activity	molecular function	GO:0016301	739	7	18094	49	MINK1,KALRN,PRKCA,PRKACB,CAMK2D,GUCY2F,GSK3B
3.591e-03	-5.63	Succinate Signalling During Inflammation	SMPDB pathways	SMP0084634	13	2	1369	10	PLCB1,PRKCA
3.611e-03	-5.62	43_KD_POSTSYNAPTIC	prosite domains	PS00405	1	1	12186	44	RAPSN
3.649e-03	-5.61	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	46	16828	47	FOXD3,RAPSN,PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,MRAS,KCND2,KALRN,DPEP1,GUCY1A2,NR4A2,CELF3,PLCE1,PRKAR2A,RYR2,TIAM2,PDE4B,NBEA,NPL,GARNL3,ITPR1,RASD1,PRKCA,PHACTR2,SLC18A2,SHOC2,PLD3,ATP2A1,LRCH1,SMPDL3B,CBL,RXRA,SYT10,SLC16A14,PLCB1,RAB37,CACNB4,KCNH6,PDE1A,PDE2A,ADCY8,PDE9A,CACNA1B,GRIA3
3.692e-03	-5.60	positive regulation of peptide secretion	biological process	GO:0002793	113	3	18204	50	PLCB1,ITPR1,ADCY8
3.715e-03	-5.60	cellular response to cytokine stimulus	biological process	GO:0071345	734	7	18204	50	LRCH1,GSK3B,CBL,MRAS,PDE2A,PLCB1,CACNB4
3.769e-03	-5.58	small molecule metabolic process	biological process	GO:0044281	1614	11	18204	50	PDE1A,NPL,PDE9A,CACNB4,GUCY2F,PDE2A,PDE4B,ADCY8,DPEP1,GUCY1A2,PLCB1
3.778e-03	-5.58	caecum	COSMIC cancer mutations	caecum	14248	46	16828	47	SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,CBL,SMPDL3B,PLD3,ATP2A1,PDE1A,KCNH6,SYT10,RXRA,SLC16A14,CACNB4,RAB37,PLCB1,CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,FOXD3,RAPSN,KCND2,MRAS,KALRN,GUCY1A2,DPEP1,TIAM2,PDE4B,NR4A2,RYR2,PRKAR2A,CELF3,PLCE1,RASD1,ITPR1,GARNL3,NPL,NBEA
3.823e-03	-5.57	human chr12p11.1	chromosome location	human chr12p11.1	2	1	26134	50	SYT10
3.827e-03	-5.57	response to peptide hormone	biological process	GO:0043434	381	5	18204	50	NR4A2,GSK3B,ADCY8,SHOC2,PLCB1
3.833e-03	-5.56	synaptic membrane	cellular component	GO:0097060	400	5	19108	50	KCND2,GRIA3,PDE2A,RAPSN,ADCY8
3.845e-03	-5.56	GnRH Signaling Pathway	SMPDB pathways	SMP0063811	47	3	1369	10	ITPR1,PLCB1,PRKCA
3.857e-03	-5.56	RAPGEF5 (Rap guanine nucleotide exchange factor 5)	protein interactions	9771	36	2	19454	50	PRKACB,MRAS
3.857e-03	-5.56	RAPGEF1 (Rap guanine nucleotide exchange factor 1)	protein interactions	2889	36	2	19454	50	CBL,MINK1
3.894e-03	-5.55	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	377	5	16828	47	SMPDL3B,PDE4B,CBL,KCNH6,PDE1A
3.921e-03	-5.54	mast cell activation	biological process	GO:0045576	34	2	18204	50	SLC18A2,CBL
3.970e-03	-5.53	Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	KEGG pathways	hsa_M00130	22	2	7161	31	PLCB1,PLCE1
3.970e-03	-5.53	Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	KEGG pathways	M00130	22	2	7161	31	PLCE1,PLCB1
4.015e-03	-5.52	cNMP-bd_dom	interpro domains	IPR000595	35	2	18521	50	KCNH6,PRKAR2A
4.019e-03	-5.52	S_TKc	smart domains	SM00220	348	6	9717	43	GSK3B,PRKACB,PRKCA,CAMK2D,KALRN,MINK1
4.085e-03	-5.50	Role of phospholipids in phagocytosis	REACTOME pathways	R-HSA-2029485	26	2	10285	38	ITPR1,PLD3
4.152e-03	-5.48	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	biological process	GO:0070059	35	2	18204	50	ITPR1,ATP2A1
4.155e-03	-5.48	biological regulation	biological process	GO:0065007	12501	43	18204	50	KALRN,RAPSN,PDE9A,SLC18A2,SHOC2,CACNB4,RXRA,PRKACB,CAMK2D,GUCY1A2,PLCE1,PDE1A,GUCY2F,LRCH1,GSK3B,CELF3,ATP2A1,RASD1,ADCY8,DPEP1,KCND2,TIAM2,PDE4B,RYR2,PDE2A,MRAS,SLC39A6,PRKCA,NR4A2,KCNH6,PRKAR2A,PLD3,FOXD3,SYT10,SMPDL3B,MINK1,ITPR1,RASGRF1,CACNA1B,GARNL3,CBL,PLCB1,GRIA3
4.209e-03	-5.47	cytoplasmic vesicle membrane	cellular component	GO:0030659	1230	9	19108	50	ADCY8,PHACTR2,RAB37,CAMK2D,PLD3,ITPR1,GRIA3,SYT10,SLC18A2
4.281e-03	-5.45	postsynaptic specialization membrane	cellular component	GO:0099634	125	3	19108	50	GRIA3,KCND2,RAPSN
4.290e-03	-5.45	KCNE4 (potassium voltage-gated channel subfamily E regulatory subunit 4)	protein interactions	23704	38	2	19454	50	PRKCA,KCND2
4.316e-03	-5.45	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	10	19454	50	PLCE1,PRKACB,RASGRF1,PRKAR2A,GSK3B,ADCY8,PLD3,PRKCA,PLCB1,RXRA
4.340e-03	-5.44	organic substance catabolic process	biological process	GO:1901575	1644	11	18204	50	CBL,GSK3B,DPEP1,PLCB1,NPL,PLCE1,PDE1A,PDE9A,SMPDL3B,PDE2A,PDE4B
4.349e-03	-5.44	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	7	16828	47	ADCY8,GUCY1A2,PLCB1,KALRN,RAPSN,CBL,PDE4B
4.351e-03	-5.44	fibula	COSMIC cancer mutations	fibula	387	5	16828	47	PDE1A,KCNH6,CBL,PDE4B,SMPDL3B
4.364e-03	-5.43	regulation of metal ion transport	biological process	GO:0010959	393	5	18204	50	PDE4B,RYR2,CAMK2D,CACNB4,ATP2A1
4.388e-03	-5.43	response to amphetamine	biological process	GO:0001975	36	2	18204	50	NR4A2,SLC18A2
4.388e-03	-5.43	negative regulation of mononuclear cell migration	biological process	GO:0071676	36	2	18204	50	PLCB1,LRCH1
4.418e-03	-5.42	Ras guanine-nucleotide exchange factors catalytic domain	gene3d domains	1.10.840.10	30	2	14470	48	PLCE1,RASGRF1
4.448e-03	-5.42	SLC25A24 (solute carrier family 25 member 24)	protein interactions	29957	129	3	19454	50	PDE2A,ATP2A1,SLC18A2
4.478e-03	-5.41	ANF_lig-bd_rcpt	interpro domains	IPR001828	37	2	18521	50	GUCY2F,GRIA3
4.587e-03	-5.38	breast-carcinoma-ER-PR-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-ER-PR-positive_carcinoma	1881	12	16828	47	PRKAR2A,RYR2,PLCE1,PRKCA,RASGRF1,PRKACB,SHOC2,GUCY1A2,MRAS,CBL,RASD1,ITPR1
4.587e-03	-5.38	ER-PR-positive_carcinoma	COSMIC cancer mutations	ER-PR-positive_carcinoma	1881	12	16828	47	RASD1,ITPR1,CBL,MRAS,GUCY1A2,PRKACB,SHOC2,RASGRF1,PRKCA,RYR2,PRKAR2A,PLCE1
4.648e-03	-5.37	positive regulation of cellular process	biological process	GO:0048522	5719	25	18204	50	GSK3B,CELF3,ATP2A1,RASGRF1,CBL,PLCB1,ADCY8,PLCE1,FOXD3,SYT10,ITPR1,MINK1,RXRA,NR4A2,GUCY1A2,CAMK2D,TIAM2,RAPSN,PDE9A,PDE2A,SHOC2,PDE4B,RYR2,CACNB4,PRKCA
4.652e-03	-5.37	ANF_receptor	pfam domains	PF01094	37	2	17795	49	GUCY2F,GRIA3
4.684e-03	-5.36	DISC1 (DISC1 scaffold protein)	protein interactions	27185	427	5	19454	50	KALRN,SHOC2,PDE4B,TIAM2,GSK3B
4.701e-03	-5.36	Angiopoietin Like Protein 8 Regulatory Pathway	WikiPathways	WP3915	132	4	5310	28	MINK1,GSK3B,CBL,RXRA
4.703e-03	-5.36	vesicle membrane	cellular component	GO:0012506	1251	9	19108	50	PLD3,ITPR1,CAMK2D,PHACTR2,RAB37,ADCY8,SLC18A2,GRIA3,SYT10
4.710e-03	-5.36	C2	pfam domains	PF00168	123	3	17795	49	PLCE1,PRKCA,SYT10
4.719e-03	-5.36	cNMP-bd_dom_sf	interpro domains	IPR018490	38	2	18521	50	KCNH6,PRKAR2A
4.729e-03	-5.35	Synthesis of IP3 and IP4 in the cytosol	REACTOME pathways	R-HSA-1855204	28	2	10285	38	PLCE1,PLCB1
4.744e-03	-5.35	DDHD2 (DDHD domain containing 2)	protein interactions	23259	40	2	19454	50	GSK3B,ATP2A1
4.744e-03	-5.35	TPPP (tubulin polymerization promoting protein)	protein interactions	11076	40	2	19454	50	GSK3B,SHOC2
4.746e-03	-5.35	ion channel inhibitor activity	molecular function	GO:0008200	38	2	18094	49	CAMK2D,ITPR1
4.805e-03	-5.34	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling	WikiPathways	WP732	20	2	5310	28	ITPR1,RASGRF1
4.805e-03	-5.34	lung-carcinoma-undifferentiated_carcinoma	COSMIC cancer mutations	lung-carcinoma-undifferentiated_carcinoma	1408	10	16828	47	RASGRF1,SHOC2,PRKACB,PRKAR2A,PRKCA,CBL,RASD1,ITPR1,GUCY1A2,MRAS
4.806e-03	-5.34	positive regulation of protein transport	biological process	GO:0051222	249	4	18204	50	ADCY8,ITPR1,PLCB1,GSK3B
4.827e-03	-5.33	chondrosarcoma	COSMIC cancer mutations	chondrosarcoma	1181	9	16828	47	RYR2,SYT10,PDE4B,RASGRF1,GUCY2F,PRKACB,ATP2A1,GUCY1A2,KALRN
4.863e-03	-5.33	RASGEF_CAT	prosite domains	PS50009	29	2	12186	44	PLCE1,RASGRF1
4.888e-03	-5.32	bone-humerus-chondrosarcoma	COSMIC cancer mutations	bone-humerus-chondrosarcoma	123	3	16828	47	SYT10,RYR2,KALRN
4.897e-03	-5.32	memory	biological process	GO:0007613	125	3	18204	50	ADCY8,PLCB1,RASGRF1
4.966e-03	-5.31	Peripla_BP_I	interpro domains	IPR028082	39	2	18521	50	GUCY2F,GRIA3
4.974e-03	-5.30	NVDCCALPHA1	prints domains	PR01631	1	1	5227	26	CACNA1B
4.974e-03	-5.30	POSTSYNAPTIC	prints domains	PR00217	1	1	5227	26	RAPSN
4.974e-03	-5.30	NURRNUCRCPTR	prints domains	PR01287	1	1	5227	26	NR4A2
4.974e-03	-5.30	KV42CHANNEL	prints domains	PR01517	1	1	5227	26	KCND2
4.994e-03	-5.30	channel inhibitor activity	molecular function	GO:0016248	39	2	18094	49	ITPR1,CAMK2D
4.994e-03	-5.30	transporter inhibitor activity	molecular function	GO:0141110	39	2	18094	49	ITPR1,CAMK2D
5.052e-03	-5.29	undifferentiated_carcinoma	COSMIC cancer mutations	undifferentiated_carcinoma	1418	10	16828	47	CBL,ITPR1,RASD1,GUCY1A2,MRAS,RASGRF1,SHOC2,PRKACB,PRKAR2A,PRKCA
5.068e-03	-5.28	CREB phosphorylation through the activation of Ras	REACTOME pathways	R-HSA-442742	29	2	10285	38	RASGRF1,CAMK2D
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	PLCE1,PLCB1,RYR2,CBL
5.131e-03	-5.27	GNB1 (G protein subunit beta 1)	protein interactions	2782	271	4	19454	50	CACNA1B,RASD1,GSK3B,KALRN
5.134e-03	-5.27	Nbr1 (NBR1, autophagy cargo receptor)	protein interactions	17966	2	1	19454	50	GSK3B
5.134e-03	-5.27	Grin2c (glutamate ionotropic receptor NMDA type subunit 2C)	protein interactions	24411	2	1	19454	50	PRKCA
5.134e-03	-5.27	Krba1 (KRAB-A domain containing 1)	protein interactions	77827	2	1	19454	50	GSK3B
5.134e-03	-5.27	IGLV3-19 (immunoglobulin lambda variable 3-19)	protein interactions	28797	2	1	19454	50	NGB
5.134e-03	-5.27	GUCY2EP (guanylate cyclase 2E, pseudogene)	protein interactions	390226	2	1	19454	50	GUCY2F
5.134e-03	-5.27	Syk (spleen associated tyrosine kinase)	protein interactions	25155	2	1	19454	50	CBL
5.134e-03	-5.27	Vta1 (vesicle (multivesicular body) trafficking 1)	protein interactions	66201	2	1	19454	50	GSK3B
5.134e-03	-5.27	Map3k11 (mitogen-activated protein kinase kinase kinase 11)	protein interactions	26403	2	1	19454	50	GSK3B
5.134e-03	-5.27	Zbed3 (zinc finger, BED type containing 3)	protein interactions	72114	2	1	19454	50	GSK3B
5.134e-03	-5.27	numb (numb)	protein interactions	34263	2	1	19454	50	PRKCA
5.134e-03	-5.27	POLR2MP1 (POLR2M pseudogene 1)	protein interactions	339970	2	1	19454	50	CBL
5.134e-03	-5.27	Spice1 (spindle and centriole associated protein 1)	protein interactions	212514	2	1	19454	50	GSK3B
5.134e-03	-5.27	Deaf1 (DEAF1, transcription factor)	protein interactions	54006	2	1	19454	50	GSK3B
5.134e-03	-5.27	Gm4779 (predicted gene 4779)	protein interactions	102634296	2	1	19454	50	GSK3B
5.134e-03	-5.27	Prune1 (prune exopolyphosphatase)	protein interactions	229589	2	1	19454	50	GSK3B
5.134e-03	-5.27	Prox2 (prospero homeobox 2)	protein interactions	73422	2	1	19454	50	GSK3B
5.134e-03	-5.27	cellular response to alkaloid	biological process	GO:0071312	39	2	18204	50	ADCY8,RYR2
5.134e-03	-5.27	long-term memory	biological process	GO:0007616	39	2	18204	50	RASGRF1,ADCY8
5.153e-03	-5.27	IRS1 (insulin receptor substrate 1)	protein interactions	3667	136	3	19454	50	ATP2A1,CBL,GSK3B
5.163e-03	-5.27	Taste transduction	KEGG pathways	ko04742	82	3	7161	31	ADCY8,PDE1A,PRKACB
5.163e-03	-5.27	Taste transduction	KEGG pathways	hsa04742	82	3	7161	31	ADCY8,PDE1A,PRKACB
5.220e-03	-5.26	GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)	protein interactions	2891	42	2	19454	50	GRIA3,PRKCA
5.220e-03	-5.26	NR2F6 (nuclear receptor subfamily 2 group F member 6)	protein interactions	2063	42	2	19454	50	RASD1,RXRA
5.220e-03	-5.26	C11orf98 (chromosome 11 open reading frame 98)	protein interactions	102288414	42	2	19454	50	PDE4B,GSK3B
5.227e-03	-5.25	Kv4.2-KChIP2 channel complex	cellular component	GO:0071193	2	1	19108	50	KCND2
5.262e-03	-5.25	ATP binding	molecular function	GO:0005524	1467	10	18094	49	ADCY8,PRKACB,GSK3B,GUCY2F,CAMK2D,CACNA1B,MINK1,KALRN,PRKCA,ATP2A1
5.263e-03	-5.25	Alzheimer's disease	KEGG pathways	hsa05010	165	4	7161	31	ITPR1,ATP2A1,PLCB1,GSK3B
5.263e-03	-5.25	Alzheimer's disease	KEGG pathways	ko05010	165	4	7161	31	PLCB1,GSK3B,ATP2A1,ITPR1
5.277e-03	-5.24	Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME pathways	R-HSA-881907	443	6	10285	38	KALRN,ITPR1,RASGRF1,PRKCA,CAMK2D,PLCB1
5.298e-03	-5.24	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	16	16828	47	PRKCA,SHOC2,PRKACB,RASGRF1,MRAS,GUCY1A2,KALRN,CBL,RXRA,PRKAR2A,PDE4B,PDE9A,NPL,RASD1,ITPR1,GRIA3
5.298e-03	-5.24	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	16	16828	47	SHOC2,PRKACB,RASGRF1,PRKCA,CBL,MRAS,KALRN,GUCY1A2,PDE4B,RXRA,PRKAR2A,RASD1,ITPR1,GRIA3,PDE9A,NPL
5.359e-03	-5.23	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	8	16828	47	RYR2,RXRA,PRKCA,SLC39A6,PDE9A,SMPDL3B,LRCH1,ITPR1
5.377e-03	-5.23	skin-hand-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-hand-carcinoma-squamous_cell_carcinoma	407	5	16828	47	KCND2,ADCY8,PLCE1,KCNH6,PDE4B
5.388e-03	-5.22	Innate Immune System	REACTOME pathways	R-HSA-168249	1285	11	10285	38	RASGRF1,PRKACB,GSK3B,PDE1A,PLD3,PRKCA,RAB37,ITPR1,ADCY8,PRKAR2A,CAMK2D
5.392e-03	-5.22	Heme_NO-bd	interpro domains	IPR011644	2	1	18521	50	GUCY1A2
5.392e-03	-5.22	TIAM1_CC-Ex	interpro domains	IPR040655	2	1	18521	50	TIAM2
5.392e-03	-5.22	Kalirin_TRIO_SH3_1	interpro domains	IPR028570	2	1	18521	50	KALRN
5.392e-03	-5.22	ASM-like_Pdiesterase_prd	interpro domains	IPR017064	2	1	18521	50	SMPDL3B
5.392e-03	-5.22	Kalirin_TRIO_SH3_2	interpro domains	IPR047053	2	1	18521	50	KALRN
5.392e-03	-5.22	Kalirin_TRIO_PH_1	interpro domains	IPR047054	2	1	18521	50	KALRN
5.392e-03	-5.22	NBEA-like_DUF1088	interpro domains	IPR010508	2	1	18521	50	NBEA
5.392e-03	-5.22	DapA-like	interpro domains	IPR002220	2	1	18521	50	NPL
5.392e-03	-5.22	VDCC_L_b3su	interpro domains	IPR008079	2	1	18521	50	CACNB4
5.392e-03	-5.22	PLC-beta_CS	interpro domains	IPR009535	2	1	18521	50	PLCB1
5.392e-03	-5.22	Tiam1/Tiam2/Sif	interpro domains	IPR043537	2	1	18521	50	TIAM2
5.392e-03	-5.22	Nuc_recep-AF1	interpro domains	IPR021780	2	1	18521	50	RXRA
5.392e-03	-5.22	STKc_GSK3	interpro domains	IPR039192	2	1	18521	50	GSK3B
5.395e-03	-5.22	positive regulation of ATP-dependent activity	biological process	GO:0032781	40	2	18204	50	RYR2,ATP2A1
5.395e-03	-5.22	calcium ion import	biological process	GO:0070509	40	2	18204	50	ATP2A1,CACNA1B
5.395e-03	-5.22	regulation of heart rate by cardiac conduction	biological process	GO:0086091	40	2	18204	50	KCNH6,CAMK2D
5.409e-03	-5.22	histone H3T6 kinase activity	molecular function	GO:0035403	2	1	18094	49	PRKCA
5.409e-03	-5.22	calcium,diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004698	2	1	18094	49	PRKCA
5.409e-03	-5.22	calcium-dependent ATPase activity	molecular function	GO:0030899	2	1	18094	49	ATP2A1
5.409e-03	-5.22	suramin binding	molecular function	GO:0043924	2	1	18094	49	RYR2
5.409e-03	-5.22	calcium- and calmodulin-responsive adenylate cyclase activity	molecular function	GO:0008294	2	1	18094	49	ADCY8
5.409e-03	-5.22	N-acetylneuraminate lyase activity	molecular function	GO:0008747	2	1	18094	49	NPL
5.458e-03	-5.21	pelvis	COSMIC cancer mutations	pelvis	984	8	16828	47	ATP2A1,GUCY1A2,RYR2,PRKAR2A,PLCE1,SLC39A6,RASGRF1,GUCY2F
5.486e-03	-5.21	positive regulation of neuromuscular synaptic transmission	biological process	GO:1900075	2	1	18204	50	RAPSN
5.486e-03	-5.21	negative regulation of type B pancreatic cell development	biological process	GO:2000077	2	1	18204	50	GSK3B
5.486e-03	-5.21	activation of protein kinase A activity	biological process	GO:0034199	2	1	18204	50	ADCY8
5.486e-03	-5.21	negative regulation of relaxation of cardiac muscle	biological process	GO:1901898	2	1	18204	50	PDE4B
5.486e-03	-5.21	positive regulation of fast-twitch skeletal muscle fiber contraction	biological process	GO:0031448	2	1	18204	50	ATP2A1
5.486e-03	-5.21	phosphatidylinositol catabolic process	biological process	GO:0031161	2	1	18204	50	PLCB1
5.486e-03	-5.21	cellular response to fluoride	biological process	GO:1902618	2	1	18204	50	PLCB1
5.486e-03	-5.21	negative regulation of monocyte extravasation	biological process	GO:2000438	2	1	18204	50	PLCB1
5.486e-03	-5.21	activation of meiosis involved in egg activation	biological process	GO:0060466	2	1	18204	50	PLCB1
5.486e-03	-5.21	positive regulation of dense core granule biogenesis	biological process	GO:2000707	2	1	18204	50	PRKCA
5.486e-03	-5.21	positive regulation of motor neuron apoptotic process	biological process	GO:2000673	2	1	18204	50	RAPSN
5.486e-03	-5.21	positive regulation of thyroid hormone mediated signaling pathway	biological process	GO:0002157	2	1	18204	50	RXRA
5.486e-03	-5.21	regulation of fast-twitch skeletal muscle fiber contraction	biological process	GO:0031446	2	1	18204	50	ATP2A1
5.486e-03	-5.21	superior temporal gyrus development	biological process	GO:0071109	2	1	18204	50	GSK3B
5.486e-03	-5.21	positive regulation of calcium ion import into sarcoplasmic reticulum	biological process	GO:1902082	2	1	18204	50	ATP2A1
5.486e-03	-5.21	negative regulation of mesenchymal stem cell differentiation	biological process	GO:2000740	2	1	18204	50	GSK3B
5.486e-03	-5.21	leukotriene D4 catabolic process	biological process	GO:1901749	2	1	18204	50	DPEP1
5.486e-03	-5.21	entry of bacterium into host cell	biological process	GO:0035635	2	1	18204	50	CBL
5.486e-03	-5.21	regulation of neuromuscular synaptic transmission	biological process	GO:1900073	2	1	18204	50	RAPSN
5.500e-03	-5.20	SH3-RhoG_link	pfam domains	PF16609	2	1	17795	49	KALRN
5.500e-03	-5.20	HNOB	pfam domains	PF07700	2	1	17795	49	GUCY1A2
5.500e-03	-5.20	DUF1154	pfam domains	PF06631	2	1	17795	49	PLCB1
5.500e-03	-5.20	DHDPS	pfam domains	PF00701	2	1	17795	49	NPL
5.500e-03	-5.20	Tiam_CC_Ex	pfam domains	PF18385	2	1	17795	49	TIAM2
5.500e-03	-5.20	Nuc_recep-AF1	pfam domains	PF11825	2	1	17795	49	RXRA
5.500e-03	-5.20	DUF1088	pfam domains	PF06469	2	1	17795	49	NBEA
5.538e-03	-5.20	human chr1p31.3	chromosome location	human chr1p31.3	58	2	26134	50	FOXD3,PDE4B
5.585e-03	-5.19	PALM2AKAP2 (PALM2 and AKAP2 fusion)	protein interactions	445815	140	3	19454	50	PRKAR2A,PRKACB,PRKCA
5.606e-03	-5.18	distal axon	cellular component	GO:0150034	273	4	19108	50	CBL,SLC18A2,RASGRF1,TIAM2
5.624e-03	-5.18	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	9	16828	47	SMPDL3B,CBL,LRCH1,ITPR1,PDE9A,SLC39A6,RYR2,PRKCA,RXRA
5.646e-03	-5.18	C2DOMAIN	prints domains	PR00360	23	2	5227	26	SYT10,PRKCA
5.662e-03	-5.17	acetylcholine receptor signaling pathway	biological process	GO:0095500	41	2	18204	50	PLCB1,ITPR1
5.663e-03	-5.17	Small_GTPase	interpro domains	IPR001806	134	3	18521	50	RASD1,MRAS,RAB37
5.682e-03	-5.17	PXMP2 (peroxisomal membrane protein 2)	protein interactions	5827	279	4	19454	50	ITPR1,ATP2A1,PRKAR2A,SLC18A2
5.773e-03	-5.15	voltage-gated calcium channel activity	molecular function	GO:0005245	42	2	18094	49	CACNB4,CACNA1B
5.777e-03	-5.15	Platelet calcium homeostasis	REACTOME pathways	R-HSA-418360	31	2	10285	38	ITPR1,ATP2A1
5.826e-03	-5.15	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	3	18094	49	ITPR1,RYR2,KCNH6
5.871e-03	-5.14	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	13	16828	47	CBL,KALRN,GUCY1A2,DPEP1,PLD3,GUCY2F,PDE4B,RASGRF1,PRKACB,TIAM2,CAMK2D,RAPSN,PRKCA
5.919e-03	-5.13	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	6	16828	47	SLC39A6,RYR2,NBEA,NPL,PLCE1,ADCY8
5.972e-03	-5.12	HLA-A (major histocompatibility complex, class I, A)	protein interactions	3105	283	4	19454	50	PRKCA,SHOC2,CBL,ATP2A1
5.974e-03	-5.12	Ras	pfam domains	PF00071	134	3	17795	49	RAB37,RASD1,MRAS
6.053e-03	-5.11	PSMC5 (proteasome 26S subunit, ATPase 5)	protein interactions	5705	454	5	19454	50	CBL,SMPDL3B,RXRA,SHOC2,MRAS
6.102e-03	-5.10	sarcolemma	cellular component	GO:0042383	142	3	19108	50	PDE9A,CAMK2D,RYR2
6.196e-03	-5.08	RAN	smart domains	SM00176	85	3	9717	43	RASD1,RAB37,MRAS
6.213e-03	-5.08	cellular response to acetylcholine	biological process	GO:1905145	43	2	18204	50	ITPR1,PLCB1
6.222e-03	-5.08	skin-acral-malignant_melanoma	COSMIC cancer mutations	skin-acral-malignant_melanoma	264	4	16828	47	RASGRF1,CBL,GARNL3,SYT10
6.234e-03	-5.08	ALG10 (ALG10 alpha-1,2-glucosyltransferase)	protein interactions	84920	46	2	19454	50	DPEP1,ATP2A1
6.237e-03	-5.08	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	5	18204	50	PLCB1,SHOC2,PLCE1,GSK3B,KALRN
6.272e-03	-5.07	DSCR9 (Down syndrome critical region 9)	protein interactions	257203	146	3	19454	50	NR4A2,KALRN,NBEA
6.308e-03	-5.07	vesicle	cellular component	GO:0031982	4141	19	19108	50	PLCB1,ADCY8,PHACTR2,PDE4B,TIAM2,MINK1,PRKACB,ITPR1,SYT10,GRIA3,DPEP1,KALRN,RAB37,CAMK2D,PRKCA,SMPDL3B,PLD3,PRKAR2A,SLC18A2
6.441e-03	-5.05	ion channel regulator activity	molecular function	GO:0099106	140	3	18094	49	CAMK2D,ITPR1,PDE4B
6.498e-03	-5.04	neuromuscular junction development	biological process	GO:0007528	44	2	18204	50	CACNB4,RAPSN
6.498e-03	-5.04	detection of visible light	biological process	GO:0009584	44	2	18204	50	CACNB4,GUCY2F
6.498e-03	-5.04	synaptic transmission, glutamatergic	biological process	GO:0035249	44	2	18204	50	GRIA3,CACNB4
6.498e-03	-5.04	leukocyte degranulation	biological process	GO:0043299	44	2	18204	50	CBL,SLC18A2
6.500e-03	-5.04	H2AC1 (H2A clustered histone 1)	protein interactions	221613	47	2	19454	50	NGB,PRKACB
6.500e-03	-5.04	GRIA1 (glutamate ionotropic receptor AMPA type subunit 1)	protein interactions	2890	47	2	19454	50	GRIA3,PRKCA
6.507e-03	-5.03	TFRC (transferrin receptor)	protein interactions	7037	462	5	19454	50	ATP2A1,PDE2A,CBL,GSK3B,NBEA
6.550e-03	-5.03	phosphatidylinositol binding	molecular function	GO:0035091	276	4	18094	49	SYT10,ITPR1,DPEP1,PLCB1
6.557e-03	-5.03	acral	COSMIC cancer mutations	acral	268	4	16828	47	GARNL3,RASGRF1,CBL,SYT10
6.571e-03	-5.03	cellular response to hypoxia	biological process	GO:0071456	139	3	18204	50	CBL,KCND2,NGB
6.571e-03	-5.03	antigen receptor-mediated signaling pathway	biological process	GO:0050851	139	3	18204	50	PDE4B,SLC39A6,CACNB4
6.589e-03	-5.02	cell surface receptor signaling pathway	biological process	GO:0007166	1992	12	18204	50	PLCB1,GRIA3,GSK3B,NR4A2,CBL,SHOC2,PDE4B,CACNB4,GUCY2F,SLC39A6,KALRN,PLCE1
6.624e-03	-5.02	-	gene3d domains	6.10.140.680	2	1	14470	48	TIAM2
6.672e-03	-5.01	Propranolol Action Pathway	SMPDB pathways	SMP0000307	57	3	1369	10	ITPR1,PLCB1,RYR2
6.672e-03	-5.01	Mexiletine Action Pathway	SMPDB pathways	SMP0000329	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Diltiazem Action Pathway	SMPDB pathways	SMP0000359	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Verapamil Action Pathway	SMPDB pathways	SMP0000375	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Isradipine Action Pathway	SMPDB pathways	SMP0000378	57	3	1369	10	ITPR1,PLCB1,RYR2
6.672e-03	-5.01	Disopyramide Action Pathway	SMPDB pathways	SMP0000325	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Bupranolol Action Pathway	SMPDB pathways	SMP0000670	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Amlodipine Action Pathway	SMPDB pathways	SMP0000376	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Bisoprolol Action Pathway	SMPDB pathways	SMP0000300	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Amiodarone Action Pathway	SMPDB pathways	SMP0000665	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Oxprenolol Action Pathway	SMPDB pathways	SMP0000304	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Alprenolol Action Pathway	SMPDB pathways	SMP0000297	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Epinephrine Action Pathway	SMPDB pathways	SMP0000661	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Felodipine Action Pathway	SMPDB pathways	SMP0000377	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Nimodipine Action Pathway	SMPDB pathways	SMP0000380	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Atenolol Action Pathway	SMPDB pathways	SMP0000298	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Bopindolol Action Pathway	SMPDB pathways	SMP0000657	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Pindolol Action Pathway	SMPDB pathways	SMP0000306	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Dobutamine Action Pathway	SMPDB pathways	SMP0000662	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Muscle/Heart Contraction	SMPDB pathways	SMP0000588	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Arbutamine Action Pathway	SMPDB pathways	SMP0000664	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Tocainide Action Pathway	SMPDB pathways	SMP0000330	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Ibutilide Action Pathway	SMPDB pathways	SMP0000332	57	3	1369	10	ITPR1,PLCB1,RYR2
6.672e-03	-5.01	Bevantolol Action Pathway	SMPDB pathways	SMP0000668	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Nisoldipine Action Pathway	SMPDB pathways	SMP0000381	57	3	1369	10	ITPR1,PLCB1,RYR2
6.672e-03	-5.01	Betaxolol Action Pathway	SMPDB pathways	SMP0000299	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Levobunolol Action Pathway	SMPDB pathways	SMP0000666	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Nebivolol Action Pathway	SMPDB pathways	SMP0000366	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Practolol Action Pathway	SMPDB pathways	SMP0000669	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Fosphenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000326	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Timolol Action Pathway	SMPDB pathways	SMP0000659	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Carteolol Action Pathway	SMPDB pathways	SMP0000658	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Nitrendipine Action Pathway	SMPDB pathways	SMP0000382	57	3	1369	10	ITPR1,PLCB1,RYR2
6.672e-03	-5.01	Acebutolol Action Pathway	SMPDB pathways	SMP0000296	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Nadolol Action Pathway	SMPDB pathways	SMP0000303	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Flecainide Action Pathway	SMPDB pathways	SMP0000331	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Penbutolol Action Pathway	SMPDB pathways	SMP0000305	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Metoprolol Action Pathway	SMPDB pathways	SMP0000302	57	3	1369	10	ITPR1,PLCB1,RYR2
6.672e-03	-5.01	Quinidine Action Pathway	SMPDB pathways	SMP0000323	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Esmolol Action Pathway	SMPDB pathways	SMP0000301	57	3	1369	10	RYR2,ITPR1,PLCB1
6.672e-03	-5.01	Sotalol Action Pathway	SMPDB pathways	SMP0000660	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Nifedipine Action Pathway	SMPDB pathways	SMP0000379	57	3	1369	10	ITPR1,PLCB1,RYR2
6.672e-03	-5.01	Metipranolol Action Pathway	SMPDB pathways	SMP0000667	57	3	1369	10	RYR2,PLCB1,ITPR1
6.672e-03	-5.01	Procainamide (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000324	57	3	1369	10	PLCB1,ITPR1,RYR2
6.672e-03	-5.01	Isoprenaline Action Pathway	SMPDB pathways	SMP0000663	57	3	1369	10	RYR2,PLCB1,ITPR1
6.729e-03	-5.00	ciliary base	cellular component	GO:0097546	47	2	19108	50	PRKAR2A,PRKACB
6.743e-03	-5.00	PFN1 (profilin 1)	protein interactions	5216	466	5	19454	50	PRKAR2A,CBL,CAMK2D,GSK3B,NBEA
6.758e-03	-5.00	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	47	16828	47	PDE4B,TIAM2,RYR2,PRKAR2A,PLCE1,CELF3,NR4A2,GARNL3,RASD1,ITPR1,NPL,NBEA,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,RAPSN,FOXD3,GUCY1A2,KALRN,DPEP1,KCND2,MRAS,PDE1A,KCNH6,CACNB4,PLCB1,RAB37,SYT10,RXRA,SLC16A14,GRIA3,CACNA1B,PDE2A,ADCY8,PDE9A,SHOC2,SLC18A2,PHACTR2,PRKCA,CBL,SMPDL3B,LRCH1,ATP2A1,PLD3,NGB
6.772e-03	-4.99	PAM (peptidylglycine alpha-amidating monooxygenase)	protein interactions	5066	48	2	19454	50	KALRN,PRKCA
6.788e-03	-4.99	glutamate receptor signaling pathway	biological process	GO:0007215	45	2	18204	50	GRIA3,PLCB1
6.793e-03	-4.99	CDC42 signaling events	Pathway Interaction DB	cdc42_pathway	70	3	2226	13	GSK3B,CBL,RASGRF1
6.853e-03	-4.98	Znf_hrmn_rcpt	interpro domains	IPR001628	46	2	18521	50	RXRA,NR4A2
6.881e-03	-4.98	DNAAF5 (dynein axonemal assembly factor 5)	protein interactions	54919	151	3	19454	50	DPEP1,PLD3,SLC18A2
6.881e-03	-4.98	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	3	19454	50	MINK1,GSK3B,TIAM2
6.940e-03	-4.97	VEGFA-VEGFR2 Pathway	REACTOME pathways	R-HSA-4420097	330	5	10285	38	PRKCA,CAMK2D,PRKACB,ITPR1,RASGRF1
6.999e-03	-4.96	prostate	COSMIC cancer mutations	prostate	13883	45	16828	47	NPL,NBEA,ITPR1,GARNL3,RASD1,RYR2,PRKAR2A,CELF3,PLCE1,NR4A2,PDE4B,TIAM2,GUCY1A2,DPEP1,KALRN,KCND2,MRAS,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,ADCY8,PDE2A,PDE9A,GRIA3,CACNA1B,CACNB4,RAB37,PLCB1,SLC16A14,RXRA,SYT10,PDE1A,KCNH6,ATP2A1,PLD3,NGB,CBL,SMPDL3B,LRCH1,PHACTR2,PRKCA,SLC18A2,SHOC2
7.009e-03	-4.96	Carvedilol Action Pathway	SMPDB pathways	SMP0000367	58	3	1369	10	PLCB1,ITPR1,RYR2
7.009e-03	-4.96	Labetalol Action Pathway	SMPDB pathways	SMP0000368	58	3	1369	10	RYR2,PLCB1,ITPR1
7.010e-03	-4.96	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	42	16828	47	GARNL3,ITPR1,NBEA,NPL,TIAM2,PDE4B,NR4A2,PRKAR2A,RYR2,PLCE1,CELF3,KCND2,MRAS,GUCY1A2,KALRN,DPEP1,CAMK2D,SLC39A6,RASGRF1,GUCY2F,CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A,PDE1A,KCNH6,RXRA,SYT10,SLC16A14,CACNB4,PLCB1,RAB37,LRCH1,CBL,SMPDL3B,NGB,PLD3,ATP2A1,SLC18A2,PRKCA,PHACTR2
7.029e-03	-4.96	CNMP_BINDING_3	prosite domains	PS50042	35	2	12186	44	PRKAR2A,KCNH6
7.047e-03	-4.96	Alzheimers Disease	WikiPathways	WP2059	148	4	5310	28	PLCB1,ATP2A1,GSK3B,ITPR1
7.049e-03	-4.95	OSTC (oligosaccharyltransferase complex non-catalytic subunit)	protein interactions	58505	49	2	19454	50	DPEP1,ATP2A1
7.058e-03	-4.95	organic cyclic compound catabolic process	biological process	GO:1901361	441	5	18204	50	PDE2A,PDE4B,DPEP1,PDE1A,PDE9A
7.065e-03	-4.95	regulation of GTPase activity	biological process	GO:0043087	278	4	18204	50	RASGRF1,GSK3B,TIAM2,LRCH1
7.084e-03	-4.95	response to acetylcholine	biological process	GO:1905144	46	2	18204	50	PLCB1,ITPR1
7.084e-03	-4.95	postsynaptic signal transduction	biological process	GO:0098926	46	2	18204	50	ITPR1,PLCB1
7.095e-03	-4.95	channel regulator activity	molecular function	GO:0016247	145	3	18094	49	ITPR1,PDE4B,CAMK2D
7.095e-03	-4.95	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	6	18204	50	PLCE1,GSK3B,KALRN,GUCY2F,PLCB1,SHOC2
7.116e-03	-4.95	zf-C4	pfam domains	PF00105	46	2	17795	49	RXRA,NR4A2
7.125e-03	-4.94	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	47	16828	47	GARNL3,RASD1,ITPR1,NBEA,NPL,PDE4B,TIAM2,PRKAR2A,RYR2,CELF3,PLCE1,NR4A2,DPEP1,GUCY1A2,KALRN,KCND2,MRAS,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,RAPSN,FOXD3,GRIA3,CACNA1B,PDE9A,PDE2A,ADCY8,PDE1A,KCNH6,CACNB4,RAB37,PLCB1,RXRA,SYT10,SLC16A14,CBL,SMPDL3B,LRCH1,ATP2A1,NGB,PLD3,SHOC2,SLC18A2,PHACTR2,PRKCA
7.135e-03	-4.94	GNAI1 (G protein subunit alpha i1)	protein interactions	2770	153	3	19454	50	NGB,CBL,RASD1
7.145e-03	-4.94	Nuclear_hrmn_rcpt	interpro domains	IPR001723	47	2	18521	50	RXRA,NR4A2
7.186e-03	-4.94	glutamate receptor binding	molecular function	GO:0035254	47	2	18094	49	RAPSN,RASGRF1
7.227e-03	-4.93	perikaryon	cellular component	GO:0043204	151	3	19108	50	PDE9A,TIAM2,KCND2
7.230e-03	-4.93	transporter regulator activity	molecular function	GO:0141108	146	3	18094	49	ITPR1,PDE4B,CAMK2D
7.242e-03	-4.93	regulated exocytosis	biological process	GO:0045055	144	3	18204	50	CBL,SYT10,SLC18A2
7.242e-03	-4.93	positive regulation of hormone secretion	biological process	GO:0046887	144	3	18204	50	ITPR1,ADCY8,PLCB1
7.324e-03	-4.92	Inactivation, recovery and regulation of the phototransduction cascade	REACTOME pathways	R-HSA-2514859	35	2	10285	38	GUCY2F,PRKCA
7.325e-03	-4.92	negative regulation of catalytic activity	biological process	GO:0043086	445	5	18204	50	DPEP1,PRKAR2A,CBL,LRCH1,GSK3B
7.330e-03	-4.92	RAB39B (RAB39B, member RAS oncogene family)	protein interactions	116442	50	2	19454	50	CBL,SLC18A2
7.330e-03	-4.92	RCBTB2 (RCC1 and BTB domain containing protein 2)	protein interactions	1102	50	2	19454	50	PDE4B,CBL
7.355e-03	-4.91	Lidocaine (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000328	59	3	1369	10	PLCB1,ITPR1,RYR2
7.386e-03	-4.91	microtubule organizing center	cellular component	GO:0005815	875	7	19108	50	GSK3B,SLC18A2,PRKACB,PRKAR2A,RAPSN,PRKCA,PDE4B
7.428e-03	-4.90	Chemokine signaling pathway	KEGG pathways	ko04062	182	4	7161	31	PLCB1,GSK3B,ADCY8,PRKACB
7.428e-03	-4.90	Chemokine signaling pathway	KEGG pathways	hsa04062	182	4	7161	31	GSK3B,PLCB1,PRKACB,ADCY8
7.443e-03	-4.90	Nucl_hrmn_rcpt_lig-bd	interpro domains	IPR000536	48	2	18521	50	RXRA,NR4A2
7.443e-03	-4.90	NHR-like_dom_sf	interpro domains	IPR035500	48	2	18521	50	NR4A2,RXRA
7.505e-03	-4.89	symporter activity	molecular function	GO:0015293	148	3	18094	49	SLC18A2,SLC16A14,SLC39A6
7.521e-03	-4.89	cellular response to decreased oxygen levels	biological process	GO:0036294	146	3	18204	50	CBL,KCND2,NGB
7.547e-03	-4.89	Amoebiasis	KEGG pathways	hsa05146	94	3	7161	31	PRKACB,PRKCA,PLCB1
7.547e-03	-4.89	Amoebiasis	KEGG pathways	ko05146	94	3	7161	31	PRKACB,PRKCA,PLCB1
7.569e-03	-4.88	Signaling by SCF-KIT	REACTOME pathways	R-HSA-1433557	337	5	10285	38	CAMK2D,CBL,PRKCA,RASGRF1,GSK3B
7.617e-03	-4.88	PTPN22 (protein tyrosine phosphatase non-receptor type 22)	protein interactions	26191	51	2	19454	50	PRKAR2A,CBL
7.626e-03	-4.88	lower_third	COSMIC cancer mutations	lower_third	7961	31	16828	47	PRKCA,PHACTR2,SLC18A2,GUCY2F,RASGRF1,MRAS,DPEP1,GUCY1A2,KALRN,ATP2A1,CBL,SYT10,RXRA,SLC16A14,CELF3,PLCE1,PLCB1,RAB37,RYR2,CACNB4,KCNH6,PDE4B,PDE2A,ADCY8,PDE9A,NBEA,RASD1,ITPR1,GARNL3,CACNA1B,GRIA3
7.663e-03	-4.87	Signaling by VEGF	REACTOME pathways	R-HSA-194138	338	5	10285	38	RASGRF1,PRKACB,ITPR1,CAMK2D,PRKCA
7.663e-03	-4.87	positive regulation of protein secretion	biological process	GO:0050714	147	3	18204	50	ADCY8,ITPR1,PLCB1
7.691e-03	-4.87	Lzts2 (leucine zipper, putative tumor suppressor 2)	protein interactions	226154	3	1	19454	50	GSK3B
7.691e-03	-4.87	Grip1 (glutamate receptor interacting protein 1)	protein interactions	74053	3	1	19454	50	RXRA
7.691e-03	-4.87	DUX4L8 (double homeobox 4 like 8 (pseudogene))	protein interactions	26583	3	1	19454	50	FOXD3
7.691e-03	-4.87	Itsn1 (intersectin 1 (SH3 domain protein 1A))	protein interactions	16443	3	1	19454	50	CBL
7.691e-03	-4.87	LINC02913 (long intergenic non-protein coding RNA 2913)	protein interactions	414318	3	1	19454	50	PDE9A
7.691e-03	-4.87	NEURL1B (neuralized E3 ubiquitin protein ligase 1B)	protein interactions	54492	3	1	19454	50	PDE9A
7.691e-03	-4.87	KIAA1614 (KIAA1614)	protein interactions	57710	3	1	19454	50	NGB
7.691e-03	-4.87	Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)	protein interactions	18708	3	1	19454	50	CBL
7.691e-03	-4.87	Grm5 (glutamate metabotropic receptor 5)	protein interactions	24418	3	1	19454	50	PRKCA
7.691e-03	-4.87	Homer1 (homer scaffold protein 1)	protein interactions	29546	3	1	19454	50	ITPR1
7.692e-03	-4.87	RasGEF	smart domains	SM00147	30	2	9717	43	PLCE1,RASGRF1
7.694e-03	-4.87	phospholipid catabolic process	biological process	GO:0009395	48	2	18204	50	SMPDL3B,PLCB1
7.703e-03	-4.87	mixed	COSMIC cancer mutations	mixed	145	3	16828	47	PDE4B,CBL,KCND2
7.729e-03	-4.86	Hormone_recep	pfam domains	PF00104	48	2	17795	49	NR4A2,RXRA
7.737e-03	-4.86	GPCR downstream signaling	REACTOME pathways	R-HSA-388396	974	9	10285	38	PLCB1,PDE4B,ADCY8,ITPR1,PDE1A,PDE2A,PRKCA,TIAM2,KALRN
7.737e-03	-4.86	The phototransduction cascade	REACTOME pathways	R-HSA-2514856	36	2	10285	38	PRKCA,GUCY2F
7.747e-03	-4.86	RmlC-like_jellyroll	interpro domains	IPR014710	49	2	18521	50	PRKAR2A,KCNH6
7.790e-03	-4.85	calcium channel regulator activity	molecular function	GO:0005246	49	2	18094	49	ITPR1,PDE4B
7.800e-03	-4.85	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	45	16828	47	PDE9A,ADCY8,PDE2A,GRIA3,CACNA1B,CACNB4,RAB37,PLCB1,SYT10,SLC16A14,RXRA,PDE1A,KCNH6,ATP2A1,NGB,PLD3,CBL,SMPDL3B,LRCH1,PRKCA,SHOC2,SLC18A2,NPL,NBEA,ITPR1,GARNL3,RASD1,RYR2,PRKAR2A,PLCE1,CELF3,NR4A2,PDE4B,TIAM2,DPEP1,GUCY1A2,KALRN,KCND2,MRAS,FOXD3,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB
7.800e-03	-4.85	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	45	16828	47	MRAS,KCND2,KALRN,GUCY1A2,DPEP1,PRKACB,SLC39A6,CAMK2D,GUCY2F,RASGRF1,FOXD3,GARNL3,ITPR1,RASD1,NPL,NBEA,TIAM2,PDE4B,NR4A2,CELF3,PLCE1,RYR2,PRKAR2A,LRCH1,SMPDL3B,CBL,PLD3,NGB,ATP2A1,SLC18A2,SHOC2,PRKCA,CACNA1B,GRIA3,ADCY8,PDE9A,PDE2A,KCNH6,PDE1A,RXRA,SYT10,SLC16A14,RAB37,PLCB1,CACNB4
7.830e-03	-4.85	alphav-beta3 integrin-PKCalpha complex	cellular component	GO:0035866	3	1	19108	50	PRKCA
7.830e-03	-4.85	guanylate cyclase complex, soluble	cellular component	GO:0008074	3	1	19108	50	GUCY1A2
7.832e-03	-4.85	RHO	prosite domains	PS51420	37	2	12186	44	RAB37,MRAS
7.832e-03	-4.85	response to organic cyclic compound	biological process	GO:0014070	843	7	18204	50	GSK3B,RXRA,CBL,PLCB1,PDE2A,RYR2,ADCY8
7.928e-03	-4.84	ITGAV (integrin subunit alpha V)	protein interactions	3685	159	3	19454	50	ATP2A1,CBL,PLD3
7.928e-03	-4.84	PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta)	protein interactions	5575	159	3	19454	50	PRKACB,GSK3B,PRKCA
8.078e-03	-4.82	HNOB_dom_associated_sf	interpro domains	IPR042463	3	1	18521	50	GUCY1A2
8.078e-03	-4.82	Cbl_PTB	interpro domains	IPR024159	3	1	18521	50	CBL
8.078e-03	-4.82	H-NOX_domain_sf	interpro domains	IPR038158	3	1	18521	50	GUCY1A2
8.078e-03	-4.82	K_chnl_volt-dep_ERG	interpro domains	IPR003967	3	1	18521	50	KCNH6
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR2
8.078e-03	-4.82	Adaptor_Cbl_EF_hand-like	interpro domains	IPR014741	3	1	18521	50	CBL
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR2
8.078e-03	-4.82	NR4A1-3	interpro domains	IPR003070	3	1	18521	50	NR4A2
8.078e-03	-4.82	Adaptor_Cbl_N_hlx	interpro domains	IPR003153	3	1	18521	50	CBL
8.078e-03	-4.82	Adaptor_Cbl_SH2-like	interpro domains	IPR014742	3	1	18521	50	CBL
8.078e-03	-4.82	Shal-type_N	interpro domains	IPR021645	3	1	18521	50	KCND2
8.078e-03	-4.82	Pept_M19	interpro domains	IPR008257	3	1	18521	50	DPEP1
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR2
8.078e-03	-4.82	PDEase_N	interpro domains	IPR013706	3	1	18521	50	PDE1A
8.078e-03	-4.82	Protein_kinase_C_a/b/g	interpro domains	IPR014375	3	1	18521	50	PRKCA
8.078e-03	-4.82	P-type_ATPase_IIA	interpro domains	IPR005782	3	1	18521	50	ATP2A1
8.078e-03	-4.82	ASM_C	interpro domains	IPR045473	3	1	18521	50	SMPDL3B
8.078e-03	-4.82	PLC-beta_C	interpro domains	IPR014815	3	1	18521	50	PLCB1
8.078e-03	-4.82	ASMase/PPN1_MPP	interpro domains	IPR041805	3	1	18521	50	SMPDL3B
8.078e-03	-4.82	Neurobeachin_a-sol	interpro domains	IPR046852	3	1	18521	50	NBEA
8.078e-03	-4.82	PLDc_3	interpro domains	IPR032803	3	1	18521	50	PLD3
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR2
8.078e-03	-4.82	K_chnl_volt-dep_Kv4	interpro domains	IPR003975	3	1	18521	50	KCND2
8.078e-03	-4.82	InsP3_rcpt	interpro domains	IPR000493	3	1	18521	50	ITPR1
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR2
8.078e-03	-4.82	Dipep_AS	interpro domains	IPR000180	3	1	18521	50	DPEP1
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR2
8.078e-03	-4.82	STKc_PKA	interpro domains	IPR044109	3	1	18521	50	PRKACB
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR2
8.078e-03	-4.82	K_chnl_volt-dep_Kv4_C	interpro domains	IPR024587	3	1	18521	50	KCND2
8.078e-03	-4.82	Adaptor_Cbl	interpro domains	IPR024162	3	1	18521	50	CBL
8.079e-03	-4.82	positive regulation of secretion by cell	biological process	GO:1903532	289	4	18204	50	ADCY8,ITPR1,PLCB1,SYT10
8.103e-03	-4.82	serotonin:sodium:chloride symporter activity	molecular function	GO:0005335	3	1	18094	49	SLC18A2
8.103e-03	-4.82	calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity	molecular function	GO:0004117	3	1	18094	49	PDE1A
8.103e-03	-4.82	voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	molecular function	GO:1905030	3	1	18094	49	KCND2
8.103e-03	-4.82	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	molecular function	GO:0004118	3	1	18094	49	PDE2A
8.103e-03	-4.82	vitamin D response element binding	molecular function	GO:0070644	3	1	18094	49	RXRA
8.103e-03	-4.82	DNA binding domain binding	molecular function	GO:0050692	3	1	18094	49	RXRA
8.103e-03	-4.82	inositol 1,4,5-trisphosphate-gated calcium channel activity	molecular function	GO:0005220	3	1	18094	49	ITPR1
8.103e-03	-4.82	calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity	molecular function	GO:0048101	3	1	18094	49	PDE1A
8.200e-03	-4.80	cNMP	smart domains	SM00100	31	2	9717	43	KCNH6,PRKAR2A
8.206e-03	-4.80	GRM1 (glutamate metabotropic receptor 1)	protein interactions	2911	53	2	19454	50	PRKCA,ITPR1
8.207e-03	-4.80	cytoplasm	cellular component	GO:0005737	12081	40	19108	50	GUCY1A2,PDE2A,RXRA,LRCH1,PDE1A,RAPSN,PRKAR2A,CAMK2D,RAB37,CBL,NGB,GARNL3,PDE9A,CELF3,RASGRF1,MINK1,PRKACB,PDE4B,PHACTR2,RASD1,RYR2,CACNB4,NR4A2,ATP2A1,KALRN,PLD3,PLCE1,PRKCA,SLC18A2,GSK3B,SLC39A6,PLCB1,NPL,ITPR1,TIAM2,ADCY8,SHOC2,GRIA3,NBEA,SYT10
8.218e-03	-4.80	cellular response to morphine	biological process	GO:0071315	3	1	18204	50	ADCY8
8.218e-03	-4.80	serotonin production involved in inflammatory response	biological process	GO:0002351	3	1	18204	50	SLC18A2
8.218e-03	-4.80	regulation of postsynaptic membrane organization	biological process	GO:1901626	3	1	18204	50	RAPSN
8.218e-03	-4.80	calcium ion import into sarcoplasmic reticulum	biological process	GO:1990036	3	1	18204	50	ATP2A1
8.218e-03	-4.80	beta-catenin destruction complex disassembly	biological process	GO:1904886	3	1	18204	50	GSK3B
8.218e-03	-4.80	response to ionomycin	biological process	GO:1904636	3	1	18204	50	PLCB1
8.218e-03	-4.80	cellular response to ionomycin	biological process	GO:1904637	3	1	18204	50	PLCB1
8.218e-03	-4.80	type B pancreatic cell apoptotic process	biological process	GO:0097050	3	1	18204	50	RYR2
8.218e-03	-4.80	negative regulation of dopaminergic neuron differentiation	biological process	GO:1904339	3	1	18204	50	GSK3B
8.218e-03	-4.80	serotonin secretion	biological process	GO:0001820	3	1	18204	50	SLC18A2
8.218e-03	-4.80	negative regulation of glycogen (starch) synthase activity	biological process	GO:2000466	3	1	18204	50	GSK3B
8.218e-03	-4.80	positive regulation of endoplasmic reticulum calcium ion concentration	biological process	GO:0032470	3	1	18204	50	ATP2A1
8.218e-03	-4.80	positive regulation of actin filament-based movement	biological process	GO:1903116	3	1	18204	50	ATP2A1
8.218e-03	-4.80	habenula development	biological process	GO:0021986	3	1	18204	50	NR4A2
8.218e-03	-4.80	regulation of retrograde trans-synaptic signaling by endocanabinoid	biological process	GO:0099178	3	1	18204	50	PLCB1
8.218e-03	-4.80	regulation of dense core granule biogenesis	biological process	GO:2000705	3	1	18204	50	PRKCA
8.218e-03	-4.80	regulation of Rap protein signal transduction	biological process	GO:0032487	3	1	18204	50	CBL
8.218e-03	-4.80	regulation of SA node cell action potential	biological process	GO:0098907	3	1	18204	50	RYR2
8.218e-03	-4.80	lactam metabolic process	biological process	GO:0072338	3	1	18204	50	DPEP1
8.218e-03	-4.80	epithalamus development	biological process	GO:0021538	3	1	18204	50	NR4A2
8.218e-03	-4.80	cellular response to 2,3,7,8-tetrachlorodibenzodioxine	biological process	GO:1904613	3	1	18204	50	PDE2A
8.218e-03	-4.80	serotonin secretion involved in inflammatory response	biological process	GO:0002442	3	1	18204	50	SLC18A2
8.218e-03	-4.80	aminergic neurotransmitter loading into synaptic vesicle	biological process	GO:0015842	3	1	18204	50	SLC18A2
8.218e-03	-4.80	positive regulation of nitric oxide mediated signal transduction	biological process	GO:0010750	3	1	18204	50	GUCY1A2
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR2
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR2
8.238e-03	-4.80	PLC-beta_C	pfam domains	PF08703	3	1	17795	49	PLCB1
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR2
8.238e-03	-4.80	Shal-type	pfam domains	PF11601	3	1	17795	49	KCND2
8.238e-03	-4.80	Peptidase_M19	pfam domains	PF01244	3	1	17795	49	DPEP1
8.238e-03	-4.80	PDEase_I_N	pfam domains	PF08499	3	1	17795	49	PDE1A
8.238e-03	-4.80	Neurobeachin	pfam domains	PF20425	3	1	17795	49	NBEA
8.238e-03	-4.80	DUF3399	pfam domains	PF11879	3	1	17795	49	KCND2
8.238e-03	-4.80	Cbl_N2	pfam domains	PF02761	3	1	17795	49	CBL
8.238e-03	-4.80	Cbl_N	pfam domains	PF02262	3	1	17795	49	CBL
8.238e-03	-4.80	ASMase_C	pfam domains	PF19272	3	1	17795	49	SMPDL3B
8.238e-03	-4.80	PLDc_3	pfam domains	PF13918	3	1	17795	49	PLD3
8.238e-03	-4.80	Cbl_N3	pfam domains	PF02762	3	1	17795	49	CBL
8.327e-03	-4.79	cellular response to nerve growth factor stimulus	biological process	GO:1990090	50	2	18204	50	SHOC2,CBL
8.327e-03	-4.79	regulation of Ras protein signal transduction	biological process	GO:0046578	50	2	18204	50	SHOC2,RASGRF1
8.348e-03	-4.79	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	19	16828	47	GUCY1A2,KALRN,ATP2A1,KCND2,CBL,LRCH1,GUCY2F,RASGRF1,PDE2A,ITPR1,CACNA1B,PLCB1,CELF3,PLCE1,RYR2,NR4A2,KCNH6,PDE1A,TIAM2
8.497e-03	-4.77	MAPK1 (mitogen-activated protein kinase 1)	protein interactions	5594	493	5	19454	50	PLCB1,PRKCA,RXRA,GSK3B,NR4A2
8.507e-03	-4.77	NOS1 (nitric oxide synthase 1)	protein interactions	4842	54	2	19454	50	PRKCA,RASD1
8.507e-03	-4.77	Pparg (peroxisome proliferator activated receptor gamma)	protein interactions	19016	54	2	19454	50	GARNL3,RXRA
8.523e-03	-4.77	HSP90AA1 (heat shock protein 90 alpha family class A member 1)	protein interactions	3320	1150	8	19454	50	PRKCA,MINK1,GSK3B,GUCY1A2,CAMK2D,RAPSN,PRKACB,PLCE1
8.558e-03	-4.76	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	9	16828	47	PHACTR2,RYR2,RASGRF1,KALRN,NBEA,KCND2,CBL,ITPR1,CACNA1B
8.651e-03	-4.75	cardiac muscle cell contraction	biological process	GO:0086003	51	2	18204	50	CAMK2D,RYR2
8.703e-03	-4.74	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	hsa04933	99	3	7161	31	PLCE1,PRKCA,PLCB1
8.703e-03	-4.74	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	ko04933	99	3	7161	31	PLCB1,PLCE1,PRKCA
8.716e-03	-4.74	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	18	16828	47	RASD1,ITPR1,PRKAR2A,PLCB1,RAB37,PLCE1,RXRA,NR4A2,KALRN,PLD3,MRAS,CBL,PRKCA,FOXD3,RASGRF1,GUCY2F,CAMK2D,PRKACB
8.720e-03	-4.74	negative regulation of cellular process	biological process	GO:0048523	5320	23	18204	50	NR4A2,PRKACB,RXRA,PRKAR2A,CAMK2D,PDE9A,PRKCA,CACNB4,PDE2A,SHOC2,PDE4B,SLC18A2,RYR2,CBL,RASD1,GSK3B,LRCH1,DPEP1,PLCB1,PLCE1,FOXD3,ITPR1,SMPDL3B
8.739e-03	-4.74	nuclear receptor activity	molecular function	GO:0004879	52	2	18094	49	NR4A2,RXRA
8.758e-03	-4.74	Retinoic acid receptors-mediated signaling	Pathway Interaction DB	retinoic_acid_pathway	25	2	2226	13	RXRA,PRKCA
8.814e-03	-4.73	PLCB1 (phospholipase C beta 1)	protein interactions	23236	55	2	19454	50	PLCB1,PRKCA
8.814e-03	-4.73	AFAP1 (actin filament associated protein 1)	protein interactions	60312	55	2	19454	50	GSK3B,PRKCA
8.814e-03	-4.73	BCL3 (BCL3 transcription coactivator)	protein interactions	602	55	2	19454	50	RXRA,GSK3B
8.814e-03	-4.73	MYL1 (myosin light chain 1)	protein interactions	4632	55	2	19454	50	CBL,PRKACB
8.831e-03	-4.73	DHDPS	smart domains	SM01130	2	1	9717	43	NPL
8.846e-03	-4.73	regulation of monoatomic ion transport	biological process	GO:0043269	466	5	18204	50	PDE4B,CAMK2D,RYR2,CACNB4,ATP2A1
8.873e-03	-4.72	muscle system process	biological process	GO:0003012	297	4	18204	50	ATP2A1,KCND2,CAMK2D,RYR2
8.917e-03	-4.72	RXRA (retinoid X receptor alpha)	protein interactions	6256	166	3	19454	50	GSK3B,NR4A2,RXRA
8.982e-03	-4.71	response to amine	biological process	GO:0014075	52	2	18204	50	SLC18A2,NR4A2
8.982e-03	-4.71	response to nerve growth factor	biological process	GO:1990089	52	2	18204	50	SHOC2,CBL
8.985e-03	-4.71	positive regulation of biological process	biological process	GO:0048518	6326	26	18204	50	SHOC2,PDE2A,PDE4B,RYR2,PRKCA,CACNB4,SLC39A6,TIAM2,RAPSN,PDE9A,GUCY1A2,CAMK2D,RXRA,NR4A2,SYT10,ITPR1,MINK1,PLCE1,FOXD3,PLCB1,ADCY8,CELF3,GSK3B,RASGRF1,ATP2A1,CBL
9.013e-03	-4.71	protein autophosphorylation	biological process	GO:0046777	156	3	18204	50	MINK1,CAMK2D,GSK3B
9.037e-03	-4.71	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME pathways	R-HSA-983695	39	2	10285	38	ITPR1,CBL
9.066e-03	-4.70	ligand-activated transcription factor activity	molecular function	GO:0098531	53	2	18094	49	RXRA,NR4A2
9.122e-03	-4.70	phosphatase complex	cellular component	GO:1903293	55	2	19108	50	ITPR1,SHOC2
9.122e-03	-4.70	protein serine/threonine phosphatase complex	cellular component	GO:0008287	55	2	19108	50	SHOC2,ITPR1
9.125e-03	-4.70	ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3)	protein interactions	94103	56	2	19454	50	SLC18A2,PDE2A
9.171e-03	-4.69	positive regulation of synaptic transmission	biological process	GO:0050806	157	3	18204	50	ADCY8,RAPSN,PDE9A
9.208e-03	-4.69	growth cone	cellular component	GO:0030426	165	3	19108	50	CBL,RASGRF1,TIAM2
9.289e-03	-4.68	lipid catabolic process	biological process	GO:0016042	301	4	18204	50	PLCE1,SMPDL3B,DPEP1,PLCB1
9.295e-03	-4.68	MAPRE1 (microtubule associated protein RP/EB family member 1)	protein interactions	22919	504	5	19454	50	SHOC2,PRKCA,PRKAR2A,PRKACB,CBL
9.335e-03	-4.67	African trypanosomiasis	KEGG pathways	hsa05143	34	2	7161	31	PRKCA,PLCB1
9.335e-03	-4.67	African trypanosomiasis	KEGG pathways	ko05143	34	2	7161	31	PLCB1,PRKCA
9.372e-03	-4.67	Small_GTP-bd_dom	interpro domains	IPR005225	161	3	18521	50	RAB37,MRAS,RASD1
9.401e-03	-4.67	secretory granule membrane	cellular component	GO:0030667	317	4	19108	50	SLC18A2,RAB37,PHACTR2,ITPR1
9.442e-03	-4.66	PRKCQ (protein kinase C theta)	protein interactions	5588	57	2	19454	50	CBL,PRKCA
9.446e-03	-4.66	Insulin Signaling	WikiPathways	WP481	161	4	5310	28	MINK1,GSK3B,CBL,PRKCA
9.476e-03	-4.66	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	26	16828	47	RASD1,ITPR1,GARNL3,CACNA1B,GRIA3,ADCY8,NBEA,KCNH6,PDE4B,SLC16A14,SYT10,RXRA,PLCE1,PLCB1,RAB37,RYR2,CBL,MRAS,KALRN,GUCY1A2,ATP2A1,SLC18A2,GUCY2F,RASGRF1,PRKCA,PHACTR2
9.571e-03	-4.65	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	6	19454	50	CBL,ITPR1,MINK1,SLC39A6,PLCB1,GRIA3
9.655e-03	-4.64	peptidyl-serine phosphorylation	biological process	GO:0018105	160	3	18204	50	GSK3B,CAMK2D,PRKCA
9.665e-03	-4.64	GAPVD1 (GTPase activating protein and VPS9 domains 1)	protein interactions	26130	171	3	19454	50	PRKAR2A,GSK3B,CBL
9.682e-03	-4.64	AGC-kinase_C	interpro domains	IPR000961	55	2	18521	50	PRKACB,PRKCA
9.763e-03	-4.63	MAP3K11 (mitogen-activated protein kinase kinase kinase 11)	protein interactions	4296	58	2	19454	50	CBL,GSK3B
9.766e-03	-4.63	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	7	16828	47	CAMK2D,CACNA1B,PRKACB,CBL,GUCY2F,PRKCA,PLCE1
9.784e-03	-4.63	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	4	16828	47	ADCY8,KCND2,SLC18A2,CACNA1B
9.819e-03	-4.62	cellular response to oxygen levels	biological process	GO:0071453	161	3	18204	50	CBL,NGB,KCND2
9.919e-03	-4.61	-	gene3d domains	6.10.250.780	3	1	14470	48	GUCY1A2
9.919e-03	-4.61	H-NOX domain	gene3d domains	3.90.1520.10	3	1	14470	48	GUCY1A2
9.919e-03	-4.61	-	gene3d domains	1.10.490.160	3	1	14470	48	RYR2
9.919e-03	-4.61	Haem NO binding associated domain	gene3d domains	3.30.450.260	3	1	14470	48	GUCY1A2
9.925e-03	-4.61	DHPICSNTHASE	prints domains	PR00146	2	1	5227	26	NPL
9.925e-03	-4.61	LCACHANNELB3	prints domains	PR01696	2	1	5227	26	CACNB4
9.971e-03	-4.61	T-Cell Receptor and Co-stimulatory Signaling	WikiPathways	WP2583	29	2	5310	28	PRKCA,GSK3B
9.975e-03	-4.61	TF (transferrin)	protein interactions	7018	173	3	19454	50	NGB,PRKACB,PRKAR2A
9.975e-03	-4.61	TEX264 (testis expressed 264, ER-phagy receptor)	protein interactions	51368	173	3	19454	50	MINK1,ATP2A1,NGB
9.975e-03	-4.61	positive regulation of protein localization	biological process	GO:1903829	480	5	18204	50	GSK3B,CACNB4,ITPR1,ADCY8,PLCB1
9.985e-03	-4.61	site of polarized growth	cellular component	GO:0030427	170	3	19108	50	TIAM2,RASGRF1,CBL
1.001e-02	-4.60	neutrophil chemotaxis	biological process	GO:0030593	55	2	18204	50	PDE4B,DPEP1
1.002e-02	-4.60	Znf_NHR/GATA	interpro domains	IPR013088	56	2	18521	50	RXRA,NR4A2
1.007e-02	-4.60	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	6	16828	47	GUCY2F,CAMK2D,PRKACB,GARNL3,PRKCA,PDE9A
1.021e-02	-4.58	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	12	16828	47	TIAM2,CAMK2D,PRKACB,RASGRF1,GUCY2F,PRKCA,RAPSN,CBL,PLD3,KALRN,GUCY1A2,DPEP1
1.024e-02	-4.58	Top2b (topoisomerase (DNA) II beta)	protein interactions	21974	4	1	19454	50	ITPR1
1.024e-02	-4.58	Pick1 (protein interacting with PRKCA 1)	protein interactions	84591	4	1	19454	50	PRKCA
1.024e-02	-4.58	Arhgef11 (Rho guanine nucleotide exchange factor 11)	protein interactions	213498	4	1	19454	50	GSK3B
1.024e-02	-4.58	Ngfr (nerve growth factor receptor)	protein interactions	24596	4	1	19454	50	CBL
1.024e-02	-4.58	Sorbs1 (sorbin and SH3 domain containing 1)	protein interactions	20411	4	1	19454	50	CBL
1.024e-02	-4.58	ORF11 (ORF11)	protein interactions	4961439	4	1	19454	50	SHOC2
1.024e-02	-4.58	FOXD1 (forkhead box D1)	protein interactions	2297	4	1	19454	50	FOXD3
1.024e-02	-4.58	Pdgfrb (platelet derived growth factor receptor, beta polypeptide)	protein interactions	18596	4	1	19454	50	CBL
1.024e-02	-4.58	Il6st (interleukin 6 signal transducer)	protein interactions	16195	4	1	19454	50	CBL
1.024e-02	-4.58	AVPR1A (arginine vasopressin receptor 1A)	protein interactions	552	4	1	19454	50	PRKCA
1.024e-02	-4.58	Axin1 (axin 1)	protein interactions	12005	4	1	19454	50	GSK3B
1.024e-02	-4.58	MCO14 (4a-hydroxytetrahydrobiopterin dehydratase)	protein interactions	856368	4	1	19454	50	PDE9A
1.024e-02	-4.58	adrenal_cortical_adenoma	COSMIC cancer mutations	adrenal_cortical_adenoma	161	3	16828	47	PDE9A,RAPSN,RYR2
1.031e-02	-4.58	dendritic spine	cellular component	GO:0043197	172	3	19108	50	PDE4B,GRIA3,KCND2
1.036e-02	-4.57	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	6	16828	47	GUCY2F,CAMK2D,GARNL3,PRKACB,PRKCA,PDE9A
1.036e-02	-4.57	cardiac muscle cell action potential	biological process	GO:0086001	56	2	18204	50	RYR2,KCNH6
1.036e-02	-4.57	negative regulation of leukocyte migration	biological process	GO:0002686	56	2	18204	50	PLCB1,LRCH1
1.036e-02	-4.57	response to amyloid-beta	biological process	GO:1904645	56	2	18204	50	CACNA1B,GSK3B
1.037e-02	-4.57	transferase activity, transferring phosphorus-containing groups	molecular function	GO:0016772	903	7	18094	49	GSK3B,PRKACB,CAMK2D,GUCY2F,KALRN,PRKCA,MINK1
1.038e-02	-4.57	positive regulation of secretion	biological process	GO:0051047	311	4	18204	50	ITPR1,ADCY8,PLCB1,SYT10
1.042e-02	-4.56	TMEM38B (transmembrane protein 38B)	protein interactions	55151	60	2	19454	50	LRCH1,ATP2A1
1.043e-02	-4.56	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	14	16828	47	GRIA3,ITPR1,GARNL3,CACNA1B,NBEA,PDE2A,PDE9A,GUCY2F,KCNH6,PDE1A,TIAM2,RYR2,RAPSN,RXRA
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	SHOC2,SLC39A6,CACNA1B
1.057e-02	-4.55	CALM3 (calmodulin 3)	protein interactions	808	334	4	19454	50	PRKAR2A,MINK1,CAMK2D,LRCH1
1.063e-02	-4.54	neuron spine	cellular component	GO:0044309	174	3	19108	50	KCND2,GRIA3,PDE4B
1.065e-02	-4.54	Dopaminergic Neurogenesis	WikiPathways	WP2855	30	2	5310	28	NR4A2,SLC18A2
1.068e-02	-4.54	MTOR (mechanistic target of rapamycin kinase)	protein interactions	2475	335	4	19454	50	DPEP1,PRKCA,SHOC2,GSK3B
1.074e-02	-4.53	hydrolase activity	molecular function	GO:0016787	2429	13	18094	49	PLCB1,DPEP1,RASD1,RAB37,PLCE1,MRAS,SMPDL3B,PLD3,PDE4B,PDE1A,PDE2A,PDE9A,ATP2A1
1.076e-02	-4.53	NBEA/BDCP_DUF4704	interpro domains	IPR031570	4	1	18521	50	NBEA
1.076e-02	-4.53	PLC-beta_C_sf	interpro domains	IPR042531	4	1	18521	50	PLCB1
1.076e-02	-4.53	CELF3/4/5/6_RRM1	interpro domains	IPR034648	4	1	18521	50	CELF3
1.076e-02	-4.53	CAB1-4_N_A-dom	interpro domains	IPR046937	4	1	18521	50	CACNB4
1.076e-02	-4.53	PLC-beta	interpro domains	IPR016280	4	1	18521	50	PLCB1
1.076e-02	-4.53	Adaptor_Cbl_N_dom_sf	interpro domains	IPR036537	4	1	18521	50	CBL
1.076e-02	-4.53	VDCC_L_bsu	interpro domains	IPR000584	4	1	18521	50	CACNB4
1.076e-02	-4.53	PDE4_UCR	interpro domains	IPR040844	4	1	18521	50	PDE4B
1.076e-02	-4.53	Retinoid-X_rcpt/HNF4	interpro domains	IPR000003	4	1	18521	50	RXRA
1.076e-02	-4.53	cAMP_dep_PK_reg_su	interpro domains	IPR012198	4	1	18521	50	PRKAR2A
1.076e-02	-4.53	NBCH_WD40	interpro domains	IPR046851	4	1	18521	50	NBEA
1.076e-02	-4.53	PLC-beta_PH	interpro domains	IPR037862	4	1	18521	50	PLCB1
1.076e-02	-4.53	Ca/CaM-dep_prot_kinase-assoc	interpro domains	IPR013543	4	1	18521	50	CAMK2D
1.076e-02	-4.53	MYL9 (myosin light chain 9)	protein interactions	10398	61	2	19454	50	FOXD3,CBL
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	PRKCA,ITPR1
1.076e-02	-4.53	PDE4D (phosphodiesterase 4D)	protein interactions	5144	61	2	19454	50	GSK3B,PDE4B
1.077e-02	-4.53	PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)	protein interactions	5290	178	3	19454	50	CBL,MRAS,PRKCA
1.077e-02	-4.53	TRIM32 (tripartite motif containing 32)	protein interactions	22954	178	3	19454	50	NGB,RXRA,PDE9A
1.079e-02	-4.53	beta-lactamase activity	molecular function	GO:0008800	4	1	18094	49	DPEP1
1.079e-02	-4.53	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	49	RYR2
1.079e-02	-4.53	AMPA glutamate receptor activity	molecular function	GO:0004971	4	1	18094	49	GRIA3
1.079e-02	-4.53	A-type (transient outward) potassium channel activity	molecular function	GO:0005250	4	1	18094	49	KCND2
1.079e-02	-4.53	monoamine:proton antiporter activity	molecular function	GO:0015311	4	1	18094	49	SLC18A2
1.079e-02	-4.53	voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels	molecular function	GO:0099511	4	1	18094	49	CACNB4
1.079e-02	-4.53	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	molecular function	GO:0099626	4	1	18094	49	CACNB4
1.079e-02	-4.53	structural constituent of postsynaptic specialization	molecular function	GO:0098879	4	1	18094	49	RAPSN
1.079e-02	-4.53	RENAL_DIPEPTIDASE_2	prosite domains	PS51365	3	1	12186	44	DPEP1
1.079e-02	-4.53	CBL_PTB	prosite domains	PS51506	3	1	12186	44	CBL
1.079e-02	-4.53	RENAL_DIPEPTIDASE_1	prosite domains	PS00869	3	1	12186	44	DPEP1
1.080e-02	-4.53	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	37	16828	47	GARNL3,ITPR1,NBEA,PDE4B,TIAM2,CELF3,PLCE1,RYR2,NR4A2,GUCY1A2,KALRN,KCND2,GUCY2F,RASGRF1,CAMK2D,SLC39A6,RAPSN,FOXD3,GRIA3,CACNA1B,ADCY8,PDE2A,PDE9A,PDE1A,PLCB1,CACNB4,RXRA,SYT10,SLC16A14,SMPDL3B,CBL,LRCH1,ATP2A1,SHOC2,SLC18A2,PHACTR2,PRKCA
1.080e-02	-4.53	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	37	16828	47	RAPSN,FOXD3,GUCY2F,RASGRF1,SLC39A6,CAMK2D,KALRN,GUCY1A2,KCND2,CELF3,PLCE1,RYR2,NR4A2,PDE4B,TIAM2,NBEA,GARNL3,ITPR1,PHACTR2,PRKCA,SLC18A2,SHOC2,ATP2A1,SMPDL3B,CBL,LRCH1,PLCB1,CACNB4,SLC16A14,RXRA,SYT10,PDE1A,PDE9A,ADCY8,PDE2A,GRIA3,CACNA1B
1.083e-02	-4.53	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	45	16828	47	CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A,PDE1A,KCNH6,SYT10,RXRA,SLC16A14,CACNB4,RAB37,PLCB1,LRCH1,CBL,SMPDL3B,PLD3,ATP2A1,SHOC2,SLC18A2,PRKCA,PHACTR2,ITPR1,RASD1,GARNL3,NBEA,TIAM2,PDE4B,NR4A2,PRKAR2A,RYR2,PLCE1,CELF3,KCND2,MRAS,GUCY1A2,DPEP1,KALRN,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,FOXD3,RAPSN
1.084e-02	-4.52	regulation of insulin secretion	biological process	GO:0050796	167	3	18204	50	ITPR1,ADCY8,PLCB1
1.084e-02	-4.52	apoptotic signaling pathway	biological process	GO:0097190	315	4	18204	50	ITPR1,PRKCA,GSK3B,ATP2A1
1.093e-02	-4.52	bone-pelvis-chondrosarcoma	COSMIC cancer mutations	bone-pelvis-chondrosarcoma	311	4	16828	47	RYR2,ATP2A1,GUCY1A2,GUCY2F
1.094e-02	-4.52	response to fluoride	biological process	GO:1902617	4	1	18204	50	PLCB1
1.094e-02	-4.52	left ventricular cardiac muscle tissue morphogenesis	biological process	GO:0003220	4	1	18204	50	RYR2
1.094e-02	-4.52	desmosome assembly	biological process	GO:0002159	4	1	18204	50	PRKCA
1.094e-02	-4.52	regulation of AV node cell action potential	biological process	GO:0098904	4	1	18204	50	RYR2
1.094e-02	-4.52	regulation of calcium ion import into sarcoplasmic reticulum	biological process	GO:1902080	4	1	18204	50	ATP2A1
1.094e-02	-4.52	regulation of angiotensin-activated signaling pathway	biological process	GO:0110061	4	1	18204	50	PRKCA
1.094e-02	-4.52	cellular response to isoquinoline alkaloid	biological process	GO:0071317	4	1	18204	50	ADCY8
1.094e-02	-4.52	regulation of twitch skeletal muscle contraction	biological process	GO:0014724	4	1	18204	50	ATP2A1
1.094e-02	-4.52	relaxation of skeletal muscle	biological process	GO:0090076	4	1	18204	50	ATP2A1
1.094e-02	-4.52	histamine uptake	biological process	GO:0051615	4	1	18204	50	SLC18A2
1.094e-02	-4.52	regulation of atrial cardiac muscle cell action potential	biological process	GO:0098910	4	1	18204	50	RYR2
1.097e-02	-4.51	CaMKII_AD	pfam domains	PF08332	4	1	17795	49	CAMK2D
1.097e-02	-4.51	DUF4704	pfam domains	PF15787	4	1	17795	49	NBEA
1.097e-02	-4.51	PDE4_UCR	pfam domains	PF18100	4	1	17795	49	PDE4B
1.097e-02	-4.51	NBCH_WD40	pfam domains	PF20426	4	1	17795	49	NBEA
1.097e-02	-4.51	VGCC_beta4Aa_N	pfam domains	PF12052	4	1	17795	49	CACNB4
1.097e-02	-4.51	PH_14	pfam domains	PF17787	4	1	17795	49	PLCB1
1.100e-02	-4.51	NOTCH1 (notch receptor 1)	protein interactions	4851	338	4	19454	50	CBL,GSK3B,NBEA,LRCH1
1.103e-02	-4.51	Retinoid X Receptor	gene3d domains	1.10.565.10	48	2	14470	48	RXRA,NR4A2
1.110e-02	-4.50	ARHGAP29 (Rho GTPase activating protein 29)	protein interactions	9411	62	2	19454	50	GSK3B,CAMK2D
1.110e-02	-4.50	CREB3L3 (cAMP responsive element binding protein 3 like 3)	protein interactions	84699	62	2	19454	50	PRKACB,GSK3B
1.121e-02	-4.49	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	7	19454	50	PDE4B,SHOC2,NGB,CBL,GSK3B,MINK1,RASGRF1
1.122e-02	-4.49	protein kinase binding	molecular function	GO:0019901	701	6	18094	49	GSK3B,NBEA,CBL,PRKAR2A,CACNB4,RYR2
1.123e-02	-4.49	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	5	16828	47	PRKCA,PRKACB,CACNA1B,CAMK2D,GUCY2F
1.140e-02	-4.47	Voltage gated Potassium channels	REACTOME pathways	R-HSA-1296072	44	2	10285	38	KCND2,KCNH6
1.144e-02	-4.47	CDK5RAP2 (CDK5 regulatory subunit associated protein 2)	protein interactions	55755	182	3	19454	50	PRKAR2A,PRKACB,PRKCA
1.144e-02	-4.47	RAB32 (RAB32, member RAS oncogene family)	protein interactions	10981	63	2	19454	50	SLC18A2,PRKAR2A
1.144e-02	-4.47	FADS2 (fatty acid desaturase 2)	protein interactions	9415	63	2	19454	50	PDE2A,ATP2A1
1.145e-02	-4.47	detection of light stimulus	biological process	GO:0009583	59	2	18204	50	GUCY2F,CACNB4
1.147e-02	-4.47	Jelly Rolls	gene3d domains	2.60.120.10	49	2	14470	48	KCNH6,PRKAR2A
1.161e-02	-4.46	SLC33A1 (solute carrier family 33 member 1)	protein interactions	9197	183	3	19454	50	CBL,ATP2A1,PLD3
1.170e-02	-4.45	Reelin signaling pathway	Pathway Interaction DB	reelinpathway	29	2	2226	13	CBL,GSK3B
1.170e-02	-4.45	VEGFR1 specific signals	Pathway Interaction DB	vegfr1_pathway	29	2	2226	13	CBL,PRKCA
1.171e-02	-4.45	nervous system process	biological process	GO:0050877	1376	9	18204	50	GSK3B,RASGRF1,KCND2,ADCY8,PLCB1,CACNB4,ITPR1,GUCY2F,SYT10
1.174e-02	-4.44	peptidyl-serine modification	biological process	GO:0018209	172	3	18204	50	CAMK2D,PRKCA,GSK3B
1.179e-02	-4.44	skin-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma	493	5	16828	47	GUCY1A2,PLCE1,FOXD3,CBL,CACNA1B
1.179e-02	-4.44	LRCH2 (leucine rich repeats and calponin homology domain containing 2)	protein interactions	57631	64	2	19454	50	GSK3B,LRCH1
1.179e-02	-4.44	SLC25A17 (solute carrier family 25 member 17)	protein interactions	10478	64	2	19454	50	ATP2A1,SLC18A2
1.179e-02	-4.44	TM9SF2 (transmembrane 9 superfamily member 2)	protein interactions	9375	64	2	19454	50	PLD3,ATP2A1
1.182e-02	-4.44	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	50	CACNB4,KCND2
1.182e-02	-4.44	regulation of action potential	biological process	GO:0098900	60	2	18204	50	CAMK2D,RYR2
1.188e-02	-4.43	centrosome	cellular component	GO:0005813	734	6	19108	50	PDE4B,PRKAR2A,RAPSN,PRKACB,GSK3B,SLC18A2
1.192e-02	-4.43	NUCLEAR_REC_DBD_1	prosite domains	PS00031	46	2	12186	44	NR4A2,RXRA
1.192e-02	-4.43	NUCLEAR_REC_DBD_2	prosite domains	PS51030	46	2	12186	44	RXRA,NR4A2
1.193e-02	-4.43	-	gene3d domains	3.40.50.2300	50	2	14470	48	GUCY2F,GRIA3
1.193e-02	-4.43	positive regulation of establishment of protein localization	biological process	GO:1904951	324	4	18204	50	GSK3B,PLCB1,ITPR1,ADCY8
1.195e-02	-4.43	PDE4DIP (phosphodiesterase 4D interacting protein)	protein interactions	9659	185	3	19454	50	PRKCA,PRKACB,PRKAR2A
1.215e-02	-4.41	RXRB (retinoid X receptor beta)	protein interactions	6257	65	2	19454	50	CACNA1B,NR4A2
1.220e-02	-4.41	negative regulation of G protein-coupled receptor signaling pathway	biological process	GO:0045744	61	2	18204	50	PDE4B,PDE2A
1.220e-02	-4.41	vacuolar localization	biological process	GO:1990849	61	2	18204	50	CBL,SLC18A2
1.220e-02	-4.41	lysosome localization	biological process	GO:0032418	61	2	18204	50	CBL,SLC18A2
1.223e-02	-4.40	response to inorganic substance	biological process	GO:0010035	505	5	18204	50	CAMK2D,RYR2,PLCB1,ADCY8,DPEP1
1.230e-02	-4.40	KLF5 (KLF transcription factor 5)	protein interactions	688	187	3	19454	50	GSK3B,PRKCA,RXRA
1.230e-02	-4.40	VMP1 (vacuole membrane protein 1)	protein interactions	81671	187	3	19454	50	DPEP1,ATP2A1,ITPR1
1.230e-02	-4.40	CEP43 (centrosomal protein 43)	protein interactions	11116	187	3	19454	50	GSK3B,PRKACB,PRKAR2A
1.241e-02	-4.39	Corticotropin-releasing hormone signaling pathway	WikiPathways	WP2355	93	3	5310	28	PRKCA,NR4A2,GSK3B
1.243e-02	-4.39	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	4	16828	47	PHACTR2,PRKACB,KCNH6,PDE1A
1.243e-02	-4.39	EF-hand	gene3d domains	1.10.238.10	272	4	14470	48	PLCB1,CBL,RYR2,PLCE1
1.256e-02	-4.38	Volt_channel_dom_sf	interpro domains	IPR027359	63	2	18521	50	CACNA1B,KCND2
1.270e-02	-4.37	bladder	COSMIC cancer mutations	bladder	14112	45	16828	47	KCND2,MRAS,DPEP1,KALRN,GUCY1A2,FOXD3,RAPSN,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,NBEA,RASD1,ITPR1,GARNL3,NR4A2,PRKAR2A,RYR2,CELF3,PLCE1,TIAM2,PDE4B,PLD3,ATP2A1,LRCH1,CBL,SMPDL3B,PRKCA,PHACTR2,SLC18A2,SHOC2,PDE2A,ADCY8,PDE9A,CACNA1B,GRIA3,SYT10,RXRA,SLC16A14,CACNB4,RAB37,PLCB1,PDE1A,KCNH6
1.270e-02	-4.37	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	45	16828	47	KCND2,MRAS,KALRN,GUCY1A2,DPEP1,FOXD3,RAPSN,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,NBEA,RASD1,GARNL3,ITPR1,NR4A2,RYR2,PRKAR2A,PLCE1,CELF3,TIAM2,PDE4B,PLD3,ATP2A1,LRCH1,CBL,SMPDL3B,PRKCA,PHACTR2,SLC18A2,SHOC2,PDE2A,ADCY8,PDE9A,CACNA1B,GRIA3,SYT10,RXRA,SLC16A14,CACNB4,RAB37,PLCB1,PDE1A,KCNH6
1.275e-02	-4.36	seminoma	COSMIC cancer mutations	seminoma	700	6	16828	47	PRKACB,CAMK2D,GUCY2F,CBL,PRKCA,PLCE1
1.277e-02	-4.36	Nicotine addiction	KEGG pathways	hsa05033	40	2	7161	31	GRIA3,CACNA1B
1.277e-02	-4.36	Nicotine addiction	KEGG pathways	ko05033	40	2	7161	31	CACNA1B,GRIA3
1.279e-02	-4.36	ACSBG1 (acyl-CoA synthetase bubblegum family member 1)	protein interactions	23205	5	1	19454	50	GSK3B
1.279e-02	-4.36	DPP10 (dipeptidyl peptidase like 10)	protein interactions	57628	5	1	19454	50	KCND2
1.279e-02	-4.36	Axin1 (axin 1)	protein interactions	79257	5	1	19454	50	GSK3B
1.279e-02	-4.36	TRPC2 (transient receptor potential cation channel subfamily C member 2 (pseudogene))	protein interactions	7221	5	1	19454	50	ITPR1
1.279e-02	-4.36	SUI2 (translation initiation factor eIF2 subunit alpha)	protein interactions	853463	5	1	19454	50	PRKCA
1.279e-02	-4.36	ANKRD6 (ankyrin repeat domain 6)	protein interactions	22881	5	1	19454	50	GSK3B
1.279e-02	-4.36	CFHR3 (complement factor H related 3)	protein interactions	10878	5	1	19454	50	PRKCA
1.279e-02	-4.36	SYT10 (synaptotagmin 10)	protein interactions	341359	5	1	19454	50	SYT10
1.279e-02	-4.36	GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2)	protein interactions	2570	5	1	19454	50	PRKCA
1.279e-02	-4.36	MEG3 (maternally expressed 3)	protein interactions	55384	5	1	19454	50	GSK3B
1.279e-02	-4.36	DLX3 (distal-less homeobox 3)	protein interactions	1747	5	1	19454	50	PRKCA
1.279e-02	-4.36	Dvl1 (dishevelled segment polarity protein 1)	protein interactions	13542	5	1	19454	50	GSK3B
1.279e-02	-4.36	ADH7 (NADP-dependent alcohol dehydrogenase)	protein interactions	850469	5	1	19454	50	PDE9A
1.280e-02	-4.36	Endothelin Pathways	WikiPathways	WP2197	33	2	5310	28	PLCB1,PRKCA
1.287e-02	-4.35	CTTNBP2NL (CTTNBP2 N-terminal like)	protein interactions	55917	67	2	19454	50	GSK3B,MINK1
1.287e-02	-4.35	PARD6A (par-6 family cell polarity regulator alpha)	protein interactions	50855	67	2	19454	50	PLCB1,PRKCA
1.287e-02	-4.35	NR1H2 (nuclear receptor subfamily 1 group H member 2)	protein interactions	7376	67	2	19454	50	RXRA,PRKCA
1.294e-02	-4.35	NR_LBD	prosite domains	PS51843	48	2	12186	44	RXRA,NR4A2
1.294e-02	-4.35	Inositol phosphate metabolism	REACTOME pathways	R-HSA-1483249	47	2	10285	38	PLCE1,PLCB1
1.294e-02	-4.35	Phase 0 - rapid depolarisation	REACTOME pathways	R-HSA-5576892	47	2	10285	38	CAMK2D,CACNB4
1.299e-02	-4.34	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	43	16828	47	PDE1A,KCNH6,SYT10,RXRA,SLC16A14,CACNB4,PLCB1,CACNA1B,GRIA3,ADCY8,PDE9A,PDE2A,SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,CBL,SMPDL3B,NGB,ATP2A1,TIAM2,PDE4B,NR4A2,RYR2,PRKAR2A,CELF3,PLCE1,RASD1,ITPR1,GARNL3,NBEA,NPL,SLC39A6,CAMK2D,RASGRF1,GUCY2F,FOXD3,RAPSN,KCND2,MRAS,KALRN,GUCY1A2
1.302e-02	-4.34	calcium- and calmodulin-dependent protein kinase complex	cellular component	GO:0005954	5	1	19108	50	CAMK2D
1.302e-02	-4.34	clathrin-sculpted monoamine transport vesicle membrane	cellular component	GO:0070083	5	1	19108	50	SLC18A2
1.302e-02	-4.34	clathrin-sculpted monoamine transport vesicle	cellular component	GO:0070081	5	1	19108	50	SLC18A2
1.313e-02	-4.33	response to endogenous stimulus	biological process	GO:0009719	1402	9	18204	50	RXRA,GSK3B,CBL,NR4A2,PLCB1,ADCY8,RYR2,PDE2A,SHOC2
1.320e-02	-4.33	-	gene3d domains	6.10.140.1750	4	1	14470	48	PHACTR2
1.320e-02	-4.33	Phospholipase C beta, distal C-terminal domain	gene3d domains	1.20.1230.10	4	1	14470	48	PLCB1
1.320e-02	-4.33	-	gene3d domains	6.10.140.2130	4	1	14470	48	PHACTR2
1.320e-02	-4.33	Adaptor protein Cbl, N-terminal domain	gene3d domains	1.20.930.20	4	1	14470	48	CBL
1.320e-02	-4.33	-	gene3d domains	2.30.29.240	4	1	14470	48	PLCB1
1.321e-02	-4.33	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	47	16828	47	PDE2A,ADCY8,PDE9A,GRIA3,CACNA1B,PLCB1,RAB37,CACNB4,RXRA,SYT10,SLC16A14,KCNH6,PDE1A,ATP2A1,NGB,PLD3,SMPDL3B,CBL,LRCH1,PHACTR2,PRKCA,SLC18A2,SHOC2,NBEA,NPL,GARNL3,ITPR1,RASD1,CELF3,PLCE1,RYR2,PRKAR2A,NR4A2,PDE4B,TIAM2,KALRN,DPEP1,GUCY1A2,MRAS,KCND2,RAPSN,FOXD3,GUCY2F,RASGRF1,PRKACB,SLC39A6,CAMK2D
1.324e-02	-4.32	FAM162A (family with sequence similarity 162 member A)	protein interactions	26355	68	2	19454	50	ATP2A1,CBL
1.326e-02	-4.32	purine ribonucleotide biosynthetic process	biological process	GO:0009152	180	3	18204	50	GUCY2F,ADCY8,GUCY1A2
1.337e-02	-4.31	regulation of ATP-dependent activity	biological process	GO:0043462	64	2	18204	50	RYR2,ATP2A1
1.347e-02	-4.31	single-stranded DNA 5'-3' DNA exonuclease activity	molecular function	GO:0045145	5	1	18094	49	PLD3
1.347e-02	-4.31	G alpha (z) signalling events	REACTOME pathways	R-HSA-418597	48	2	10285	38	ADCY8,PRKCA
1.349e-02	-4.31	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	4	16828	47	PRKACB,KCNH6,PDE1A,PHACTR2
1.366e-02	-4.29	Purkinje myocyte to ventricular cardiac muscle cell signaling	biological process	GO:0086029	5	1	18204	50	RYR2
1.366e-02	-4.29	positive regulation of the force of heart contraction	biological process	GO:0098735	5	1	18204	50	RYR2
1.366e-02	-4.29	regulation of platelet-derived growth factor receptor-alpha signaling pathway	biological process	GO:2000583	5	1	18204	50	CBL
1.366e-02	-4.29	regulation of glycogen (starch) synthase activity	biological process	GO:2000465	5	1	18204	50	GSK3B
1.366e-02	-4.29	sugar mediated signaling pathway	biological process	GO:0010182	5	1	18204	50	ADCY8
1.366e-02	-4.29	histamine secretion by mast cell	biological process	GO:0002553	5	1	18204	50	SLC18A2
1.366e-02	-4.29	histamine production involved in inflammatory response	biological process	GO:0002349	5	1	18204	50	SLC18A2
1.366e-02	-4.29	cellular response to corticotropin-releasing hormone stimulus	biological process	GO:0071376	5	1	18204	50	NR4A2
1.366e-02	-4.29	response to 2,3,7,8-tetrachlorodibenzodioxine	biological process	GO:1904612	5	1	18204	50	PDE2A
1.366e-02	-4.29	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	biological process	GO:0071878	5	1	18204	50	PDE4B
1.366e-02	-4.29	glucose mediated signaling pathway	biological process	GO:0010255	5	1	18204	50	ADCY8
1.366e-02	-4.29	positive regulation of protein localization to nucleolus	biological process	GO:1904751	5	1	18204	50	CACNB4
1.366e-02	-4.29	hexose mediated signaling	biological process	GO:0009757	5	1	18204	50	ADCY8
1.366e-02	-4.29	response to corticotropin-releasing hormone	biological process	GO:0043435	5	1	18204	50	NR4A2
1.366e-02	-4.29	histamine secretion involved in inflammatory response	biological process	GO:0002441	5	1	18204	50	SLC18A2
1.366e-02	-4.29	activation of meiosis	biological process	GO:0090427	5	1	18204	50	PLCB1
1.366e-02	-4.29	head_neck	COSMIC cancer mutations	head_neck	15361	47	16828	47	RASD1,GARNL3,ITPR1,NPL,NBEA,TIAM2,PDE4B,NR4A2,PLCE1,CELF3,PRKAR2A,RYR2,MRAS,KCND2,DPEP1,KALRN,GUCY1A2,PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,FOXD3,RAPSN,CACNA1B,GRIA3,ADCY8,PDE9A,PDE2A,KCNH6,PDE1A,SLC16A14,SYT10,RXRA,RAB37,PLCB1,CACNB4,LRCH1,SMPDL3B,CBL,NGB,PLD3,ATP2A1,SLC18A2,SHOC2,PRKCA,PHACTR2
1.372e-02	-4.29	MFS	interpro domains	IPR011701	66	2	18521	50	SLC16A14,SLC18A2
1.389e-02	-4.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia_therapy_related	5	1	16828	47	CBL
1.389e-02	-4.28	acute_lymphoblastic_leukaemia_therapy_related	COSMIC cancer mutations	acute_lymphoblastic_leukaemia_therapy_related	5	1	16828	47	CBL
1.395e-02	-4.27	CALM2 (calmodulin 2)	protein interactions	805	196	3	19454	50	PRKAR2A,CAMK2D,ADCY8
1.399e-02	-4.27	AXIN2 (axin 2)	protein interactions	8313	70	2	19454	50	GSK3B,PRKCA
1.399e-02	-4.27	SHOC2 (SHOC2 leucine rich repeat scaffold protein)	protein interactions	8036	70	2	19454	50	SHOC2,MRAS
1.403e-02	-4.27	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	COSMIC cancer mutations	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	181	3	16828	47	ATP2A1,NBEA,GUCY1A2
1.418e-02	-4.26	neutrophil migration	biological process	GO:1990266	66	2	18204	50	PDE4B,DPEP1
1.418e-02	-4.26	myeloid cell activation involved in immune response	biological process	GO:0002275	66	2	18204	50	SLC18A2,CBL
1.420e-02	-4.25	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	41	16828	47	PDE9A,PDE2A,ADCY8,GRIA3,CACNA1B,PLCB1,CACNB4,SLC16A14,SYT10,RXRA,KCNH6,PDE1A,ATP2A1,PLD3,SMPDL3B,CBL,LRCH1,PHACTR2,PRKCA,SLC18A2,SHOC2,NBEA,NPL,ITPR1,GARNL3,PLCE1,RYR2,PRKAR2A,PDE4B,TIAM2,KALRN,DPEP1,GUCY1A2,MRAS,KCND2,RAPSN,GUCY2F,RASGRF1,PRKACB,CAMK2D,SLC39A6
1.424e-02	-4.25	WNT_subtype	COSMIC cancer mutations	WNT_subtype	182	3	16828	47	ATP2A1,GUCY1A2,NBEA
1.424e-02	-4.25	MFS_1	pfam domains	PF07690	66	2	17795	49	SLC16A14,SLC18A2
1.427e-02	-4.25	cellular response to metal ion	biological process	GO:0071248	185	3	18204	50	CAMK2D,DPEP1,ADCY8
1.430e-02	-4.25	nucleobase-containing compound catabolic process	biological process	GO:0034655	342	4	18204	50	PDE2A,PDE4B,PDE1A,PDE9A
1.435e-02	-4.24	catabolic process	biological process	GO:0009056	1936	11	18204	50	PDE9A,PLCE1,NPL,PDE1A,PDE4B,PDE2A,SMPDL3B,GSK3B,CBL,PLCB1,DPEP1
1.435e-02	-4.24	phosphorylation	biological process	GO:0016310	729	6	18204	50	PRKCA,MINK1,CAMK2D,GSK3B,KALRN,PRKACB
1.438e-02	-4.24	Developmental Biology	REACTOME pathways	R-HSA-1266738	1075	9	10285	38	KALRN,GSK3B,RASGRF1,CACNB4,PRKACB,PRKCA,FOXD3,RXRA,CAMK2D
1.444e-02	-4.24	response to metal ion	biological process	GO:0010038	343	4	18204	50	DPEP1,ADCY8,CAMK2D,RYR2
1.448e-02	-4.23	kidney	COSMIC cancer mutations	kidney	15380	47	16828	47	PHACTR2,PRKCA,SHOC2,SLC18A2,ATP2A1,NGB,PLD3,CBL,SMPDL3B,LRCH1,CACNB4,RAB37,PLCB1,SLC16A14,SYT10,RXRA,PDE1A,KCNH6,PDE9A,ADCY8,PDE2A,GRIA3,CACNA1B,RAPSN,FOXD3,RASGRF1,GUCY2F,CAMK2D,SLC39A6,PRKACB,KALRN,GUCY1A2,DPEP1,KCND2,MRAS,PRKAR2A,RYR2,CELF3,PLCE1,NR4A2,PDE4B,TIAM2,NPL,NBEA,GARNL3,ITPR1,RASD1
1.459e-02	-4.23	myeloid leukocyte mediated immunity	biological process	GO:0002444	67	2	18204	50	SLC18A2,CBL
1.462e-02	-4.23	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	4	10285	38	CAMK2D,PRKCA,RASGRF1,ITPR1
1.470e-02	-4.22	Activation of AMPA receptors	REACTOME pathways	R-HSA-399710	4	1	10285	38	GRIA3
1.477e-02	-4.22	PH	pfam domains	PF00169	187	3	17795	49	RASGRF1,KALRN,TIAM2
1.481e-02	-4.21	Erythroid Transcription Factor GATA-1, subunit A	gene3d domains	3.30.50.10	56	2	14470	48	NR4A2,RXRA
1.485e-02	-4.21	ERGCHANNEL	prints domains	PR01470	3	1	5227	26	KCNH6
1.485e-02	-4.21	SHALCHANNEL	prints domains	PR01497	3	1	5227	26	KCND2
1.485e-02	-4.21	INSP3RECEPTR	prints domains	PR00779	3	1	5227	26	ITPR1
1.485e-02	-4.21	RYANODINER	prints domains	PR00795	3	1	5227	26	RYR2
1.485e-02	-4.21	NUCLEARECPTR	prints domains	PR01284	3	1	5227	26	NR4A2
1.487e-02	-4.21	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	20	16828	47	PRKAR2A,PLCB1,PLCE1,RAB37,ITPR1,RASD1,GRIA3,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,PRKCA,FOXD3,LRCH1,CBL,PLD3,KCND2,MRAS,KALRN
1.487e-02	-4.21	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	20	16828	47	PLCB1,RAB37,PLCE1,PRKAR2A,ITPR1,RASD1,GRIA3,FOXD3,PRKCA,PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,MRAS,PLD3,KCND2,KALRN,LRCH1,CBL
1.494e-02	-4.20	cilium	cellular component	GO:0005929	772	6	19108	50	PRKAR2A,PRKACB,AJM1,PRKCA,CBL,GUCY2F
1.512e-02	-4.19	Nuclear Receptor transcription pathway	REACTOME pathways	R-HSA-383280	51	2	10285	38	RXRA,NR4A2
1.512e-02	-4.19	Melatonin metabolism and effects	WikiPathways	WP3298	36	2	5310	28	PRKCA,GSK3B
1.515e-02	-4.19	RSPRY1 (ring finger and SPRY domain containing 1)	protein interactions	89970	73	2	19454	50	PLD3,PDE9A
1.526e-02	-4.18	cellular response to lipid	biological process	GO:0071396	534	5	18204	50	PLCB1,PDE4B,ADCY8,GSK3B,RXRA
1.531e-02	-4.18	CERS2 (ceramide synthase 2)	protein interactions	29956	203	3	19454	50	SMPDL3B,PRKCA,ATP2A1
1.531e-02	-4.18	DPYSL2 (dihydropyrimidinase like 2)	protein interactions	1808	203	3	19454	50	NGB,CBL,GSK3B
1.532e-02	-4.18	CABYR (calcium binding tyrosine phosphorylation regulated)	protein interactions	26256	6	1	19454	50	GSK3B
1.532e-02	-4.18	ARMS2 (age-related maculopathy susceptibility 2)	protein interactions	387715	6	1	19454	50	PRKCA
1.532e-02	-4.18	Mapk1 (mitogen-activated protein kinase 1)	protein interactions	26413	6	1	19454	50	NR4A2
1.532e-02	-4.18	Ncoa2 (nuclear receptor coactivator 2)	protein interactions	17978	6	1	19454	50	RXRA
1.532e-02	-4.18	Cep250 (centrosomal protein 250)	protein interactions	16328	6	1	19454	50	PRKAR2A
1.532e-02	-4.18	Grap2 (GRB2-related adaptor protein 2)	protein interactions	17444	6	1	19454	50	CBL
1.532e-02	-4.18	CIBAR2 (CBY1 interacting BAR domain containing 2)	protein interactions	339145	6	1	19454	50	CAMK2D
1.532e-02	-4.18	SLC45A1 (solute carrier family 45 member 1)	protein interactions	50651	6	1	19454	50	FOXD3
1.532e-02	-4.18	Csnk1d (casein kinase 1, delta)	protein interactions	64462	6	1	19454	50	PRKCA
1.532e-02	-4.18	TCEAL5 (transcription elongation factor A like 5)	protein interactions	340543	6	1	19454	50	NR4A2
1.532e-02	-4.18	AKAP4 (A-kinase anchoring protein 4)	protein interactions	8852	6	1	19454	50	PRKAR2A
1.542e-02	-4.17	Phenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000327	77	3	1369	10	ITPR1,PLCB1,RYR2
1.552e-02	-4.17	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	45	16828	47	SMPDL3B,CBL,LRCH1,ATP2A1,PLD3,NGB,SLC18A2,SHOC2,PHACTR2,PRKCA,GRIA3,CACNA1B,PDE2A,ADCY8,PDE9A,KCNH6,PDE1A,RAB37,PLCB1,CACNB4,SLC16A14,SYT10,RXRA,DPEP1,GUCY1A2,KALRN,MRAS,KCND2,GUCY2F,RASGRF1,PRKACB,CAMK2D,SLC39A6,RAPSN,GARNL3,ITPR1,NPL,NBEA,PDE4B,TIAM2,CELF3,PLCE1,RYR2,PRKAR2A,NR4A2
1.554e-02	-4.16	SH3GL2 (SH3 domain containing GRB2 like 2, endophilin A1)	protein interactions	6456	74	2	19454	50	CBL,TIAM2
1.554e-02	-4.16	IRF1 (interferon regulatory factor 1)	protein interactions	3659	74	2	19454	50	CBL,GSK3B
1.554e-02	-4.16	PIGK (phosphatidylinositol glycan anchor biosynthesis class K)	protein interactions	10026	74	2	19454	50	PRKCA,PLD3
1.560e-02	-4.16	rod photoreceptor outer segment	cellular component	GO:0120200	6	1	19108	50	GUCY2F
1.560e-02	-4.16	platelet dense granule membrane	cellular component	GO:0031088	6	1	19108	50	ITPR1
1.560e-02	-4.16	calcineurin complex	cellular component	GO:0005955	6	1	19108	50	ITPR1
1.571e-02	-4.15	testis	COSMIC cancer mutations	testis	733	6	16828	47	GUCY2F,CACNA1B,CAMK2D,PRKACB,PLCE1,PRKCA
1.573e-02	-4.15	negative regulation of molecular function	biological process	GO:0044092	744	6	18204	50	CBL,LRCH1,GSK3B,DPEP1,CAMK2D,PRKAR2A
1.577e-02	-4.15	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	22	16828	47	FOXD3,PRKCA,PRKACB,SLC18A2,SLC39A6,CAMK2D,GUCY2F,RASGRF1,MRAS,PLD3,KALRN,CBL,PLCE1,PLCB1,RAB37,RYR2,PRKAR2A,PDE4B,ADCY8,RASD1,ITPR1,GRIA3
1.577e-02	-4.15	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	22	16828	47	PDE4B,RAB37,PLCB1,PLCE1,PRKAR2A,RYR2,RASD1,ITPR1,GRIA3,ADCY8,SLC18A2,PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,FOXD3,PRKCA,CBL,MRAS,PLD3,KALRN
1.585e-02	-4.14	negative regulation of TOR signaling	biological process	GO:0032007	70	2	18204	50	GSK3B,PRKACB
1.587e-02	-4.14	B3GAT1 (beta-1,3-glucuronyltransferase 1)	protein interactions	27087	377	4	19454	50	SLC39A6,ITPR1,MINK1,PLD3
1.592e-02	-4.14	ITPR3 (inositol 1,4,5-trisphosphate receptor type 3)	protein interactions	3710	206	3	19454	50	ATP2A1,ITPR1,CAMK2D
1.592e-02	-4.14	AKAP9 (A-kinase anchoring protein 9)	protein interactions	10142	206	3	19454	50	PRKCA,PRKACB,PRKAR2A
1.594e-02	-4.14	ARFGEF3 (ARFGEF family member 3)	protein interactions	57221	75	2	19454	50	PRKCA,GSK3B
1.594e-02	-4.14	RELB (RELB proto-oncogene, NF-kB subunit)	protein interactions	5971	75	2	19454	50	CBL,GSK3B
1.606e-02	-4.13	lamellipodium	cellular component	GO:0030027	203	3	19108	50	SLC39A6,PLCE1,TIAM2
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY8
1.614e-02	-4.13	cAMP-dependent protein kinase activity	molecular function	GO:0004691	6	1	18094	49	PRKACB
1.614e-02	-4.13	retinoic acid-responsive element binding	molecular function	GO:0044323	6	1	18094	49	RXRA
1.614e-02	-4.13	phospholipase D activity	molecular function	GO:0004630	6	1	18094	49	PLD3
1.614e-02	-4.13	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	49	RYR2
1.629e-02	-4.12	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	739	6	16828	47	RYR2,NBEA,KCND2,CBL,RASGRF1,SLC18A2
1.629e-02	-4.12	acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_T_cell_leukaemia	739	6	16828	47	RYR2,NBEA,KCND2,RASGRF1,CBL,SLC18A2
1.631e-02	-4.12	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	46	16828	47	SLC18A2,SHOC2,PHACTR2,PRKCA,CBL,SMPDL3B,LRCH1,ATP2A1,NGB,PDE1A,KCNH6,CACNB4,PLCB1,RAB37,SLC16A14,RXRA,SYT10,GRIA3,CACNA1B,PDE2A,PDE9A,ADCY8,RASGRF1,GUCY2F,CAMK2D,SLC39A6,PRKACB,RAPSN,FOXD3,KALRN,GUCY1A2,DPEP1,KCND2,MRAS,PDE4B,TIAM2,PRKAR2A,RYR2,PLCE1,CELF3,NR4A2,ITPR1,GARNL3,RASD1,NBEA,NPL
1.633e-02	-4.11	BCL2L1 (BCL2 like 1)	protein interactions	598	208	3	19454	50	GSK3B,PDE2A,PLD3
1.635e-02	-4.11	RAPGEF6 (Rap guanine nucleotide exchange factor 6)	protein interactions	51735	76	2	19454	50	MRAS,GSK3B
1.635e-02	-4.11	ALG9 (ALG9 alpha-1,2-mannosyltransferase)	protein interactions	79796	76	2	19454	50	GRIA3,ATP2A1
1.637e-02	-4.11	cellular response to ether	biological process	GO:0071362	6	1	18204	50	PLCB1
1.637e-02	-4.11	leukotriene catabolic process	biological process	GO:0036100	6	1	18204	50	DPEP1
1.637e-02	-4.11	ubiquitin-dependent endocytosis	biological process	GO:0070086	6	1	18204	50	CBL
1.637e-02	-4.11	dopamine secretion	biological process	GO:0014046	6	1	18204	50	SLC18A2
1.637e-02	-4.11	sphingomyelin catabolic process	biological process	GO:0006685	6	1	18204	50	SMPDL3B
1.637e-02	-4.11	Purkinje myocyte to ventricular cardiac muscle cell communication	biological process	GO:0086068	6	1	18204	50	RYR2
1.637e-02	-4.11	inositol trisphosphate metabolic process	biological process	GO:0032957	6	1	18204	50	PLCB1
1.637e-02	-4.11	negative regulation of cGMP-mediated signaling	biological process	GO:0010754	6	1	18204	50	PDE2A
1.637e-02	-4.11	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	GO:0106071	6	1	18204	50	PRKCA
1.637e-02	-4.11	positive regulation of vitamin D receptor signaling pathway	biological process	GO:0070564	6	1	18204	50	RXRA
1.637e-02	-4.11	negative regulation of T cell migration	biological process	GO:2000405	6	1	18204	50	LRCH1
1.637e-02	-4.11	general adaptation syndrome	biological process	GO:0051866	6	1	18204	50	NR4A2
1.637e-02	-4.11	gamma-aminobutyric acid secretion	biological process	GO:0014051	6	1	18204	50	CACNB4
1.640e-02	-4.11	ribonucleotide biosynthetic process	biological process	GO:0009260	195	3	18204	50	ADCY8,GUCY2F,GUCY1A2
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY8
1.641e-02	-4.11	PH_BEACH	pfam domains	PF14844	6	1	17795	49	NBEA
1.648e-02	-4.11	-	gene3d domains	6.10.140.620	5	1	14470	48	CAMK2D
1.649e-02	-4.11	homeostatic process	biological process	GO:0042592	1456	9	18204	50	ITPR1,CACNB4,SLC39A6,RYR2,PDE4B,PRKACB,ATP2A1,ADCY8,CAMK2D
1.656e-02	-4.10	leukotriene biosynthesis	BIOCYC pathways	HUMAN_PWY66-375	5	1	902	3	DPEP1
1.656e-02	-4.10	leukotriene biosynthesis	BIOCYC pathways	META_PWY66-375	5	1	902	3	DPEP1
1.672e-02	-4.09	negative regulation of neuron differentiation	biological process	GO:0045665	72	2	18204	50	GSK3B,SHOC2
1.676e-02	-4.09	AGC_KINASE_CTER	prosite domains	PS51285	55	2	12186	44	PRKACB,PRKCA
1.685e-02	-4.08	regulation of peptide hormone secretion	biological process	GO:0090276	197	3	18204	50	PLCB1,ITPR1,ADCY8
1.689e-02	-4.08	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	9	16828	47	CACNA1B,KCND2,ATP2A1,PRKACB,PDE1A,GUCY2F,RASGRF1,RXRA,RYR2
1.691e-02	-4.08	RHO	smart domains	SM00174	123	3	9717	43	MRAS,RAB37,RASD1
1.702e-02	-4.07	RET signaling	REACTOME pathways	R-HSA-8853659	270	4	10285	38	CAMK2D,PRKCA,RASGRF1,PRKACB
1.705e-02	-4.07	Autophagy - animal	KEGG pathways	ko04140	127	3	7161	31	PRKACB,ITPR1,MRAS
1.705e-02	-4.07	Autophagy - animal	KEGG pathways	hsa04140	127	3	7161	31	ITPR1,PRKACB,MRAS
1.707e-02	-4.07	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	18	16828	47	GUCY2F,RASGRF1,CBL,LRCH1,KALRN,GUCY1A2,ATP2A1,KCND2,KCNH6,PDE1A,TIAM2,PLCE1,PLCB1,CELF3,RYR2,NR4A2,ITPR1,CACNA1B
1.708e-02	-4.07	neoplasm	COSMIC cancer mutations	neoplasm	14787	46	16828	47	PRKCA,PHACTR2,SLC18A2,SHOC2,PLD3,NGB,ATP2A1,LRCH1,CBL,SMPDL3B,SLC16A14,SYT10,RXRA,CACNB4,PLCB1,PDE1A,KCNH6,ADCY8,PDE2A,PDE9A,CACNA1B,GRIA3,FOXD3,RAPSN,SLC39A6,CAMK2D,PRKACB,RASGRF1,GUCY2F,KCND2,MRAS,KALRN,GUCY1A2,DPEP1,NR4A2,PRKAR2A,RYR2,CELF3,PLCE1,TIAM2,PDE4B,NBEA,NPL,GARNL3,RASD1,ITPR1
1.709e-02	-4.07	human chr7q31.31	chromosome location	human chr7q31.31	9	1	26134	50	KCND2
1.711e-02	-4.07	positive regulation of cell projection organization	biological process	GO:0031346	361	4	18204	50	SHOC2,PLCE1,GSK3B,TIAM2
1.712e-02	-4.07	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	18	16828	47	CACNA1B,ITPR1,RYR2,PLCB1,CELF3,PLCE1,NR4A2,TIAM2,PDE1A,KCNH6,ATP2A1,KALRN,GUCY1A2,KCND2,CBL,LRCH1,RASGRF1,GUCY2F
1.721e-02	-4.06	leg	COSMIC cancer mutations	leg	969	7	16828	47	GUCY1A2,PLCB1,ATP2A1,KCND2,SYT10,KCNH6,PDE1A
1.721e-02	-4.06	regulation of cellular localization	biological process	GO:0060341	983	7	18204	50	PLCB1,CAMK2D,CACNB4,ITPR1,ADCY8,GSK3B,ATP2A1
1.725e-02	-4.06	regulation of secretion by cell	biological process	GO:1903530	551	5	18204	50	SYT10,PLCB1,CACNB4,ADCY8,ITPR1
1.736e-02	-4.05	Beta-catenin independent WNT signaling	REACTOME pathways	R-HSA-3858494	149	3	10285	38	PRKCA,PLCB1,ITPR1
1.737e-02	-4.05	Hedgehog signaling pathway	KEGG pathways	ko04340	47	2	7161	31	GSK3B,PRKACB
1.737e-02	-4.05	Hedgehog signaling pathway	KEGG pathways	hsa04340	47	2	7161	31	GSK3B,PRKACB
1.741e-02	-4.05	lymph_node	COSMIC cancer mutations	lymph_node	1703	10	16828	47	RASGRF1,PRKACB,PRKAR2A,RYR2,PLCB1,PRKCA,CBL,CACNA1B,ITPR1,PLD3
1.750e-02	-4.05	ZnF_C4	smart domains	SM00399	46	2	9717	43	RXRA,NR4A2
1.754e-02	-4.04	regulation of peptide transport	biological process	GO:0090087	200	3	18204	50	ADCY8,ITPR1,PLCB1
1.754e-02	-4.04	regulation of peptide secretion	biological process	GO:0002791	200	3	18204	50	ITPR1,ADCY8,PLCB1
1.758e-02	-4.04	positive regulation of response to stimulus	biological process	GO:0048584	2266	12	18204	50	PLCB1,GUCY1A2,CBL,RXRA,RASGRF1,MINK1,SLC39A6,CACNB4,PRKCA,PDE4B,PDE2A,SHOC2
1.759e-02	-4.04	PRKAG3 (protein kinase AMP-activated non-catalytic subunit gamma 3)	protein interactions	53632	79	2	19454	50	AJM1,CAMK2D
1.762e-02	-4.04	Nuclear Receptors	WikiPathways	WP170	39	2	5310	28	NR4A2,RXRA
1.763e-02	-4.04	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	37	16828	47	CAMK2D,SLC39A6,GUCY2F,RASGRF1,RAPSN,MRAS,KCND2,GUCY1A2,KALRN,TIAM2,PDE4B,NR4A2,PLCE1,CELF3,RYR2,PRKAR2A,GARNL3,NPL,SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,CBL,ATP2A1,KCNH6,PDE1A,RXRA,SYT10,SLC16A14,PLCB1,CACNB4,CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A
1.763e-02	-4.04	Wnt Signaling Pathway and Pluripotency	WikiPathways	WP399	106	3	5310	28	PRKCA,GSK3B,FOXD3
1.774e-02	-4.03	FLNA (filamin A)	protein interactions	2316	593	5	19454	50	PDE4B,PRKCA,CBL,KCND2,GSK3B
1.776e-02	-4.03	GABA-ergic synapse	cellular component	GO:0098982	78	2	19108	50	KCND2,PLCB1
1.777e-02	-4.03	negative regulation of hydrolase activity	biological process	GO:0051346	201	3	18204	50	GSK3B,LRCH1,DPEP1
1.786e-02	-4.03	Gadd45b (growth arrest and DNA-damage-inducible 45 beta)	protein interactions	17873	7	1	19454	50	RXRA
1.786e-02	-4.03	PNPLA7 (patatin like phospholipase domain containing 7)	protein interactions	375775	7	1	19454	50	PLD3
1.786e-02	-4.03	GPR137 (G protein-coupled receptor 137)	protein interactions	56834	7	1	19454	50	DPEP1
1.786e-02	-4.03	SLC25A52 (solute carrier family 25 member 52)	protein interactions	147407	7	1	19454	50	SLC18A2
1.786e-02	-4.03	OTOS (otospiralin)	protein interactions	150677	7	1	19454	50	NGB
1.786e-02	-4.03	CASKIN1 (CASK interacting protein 1)	protein interactions	57524	7	1	19454	50	MINK1
1.786e-02	-4.03	RTL1 (retrotransposon Gag like 1)	protein interactions	388015	7	1	19454	50	NGB
1.786e-02	-4.03	GUCY2F (guanylate cyclase 2F, retinal)	protein interactions	2986	7	1	19454	50	GUCY2F
1.800e-02	-4.02	ribose phosphate biosynthetic process	biological process	GO:0046390	202	3	18204	50	GUCY1A2,ADCY8,GUCY2F
1.801e-02	-4.02	MAP2 (microtubule associated protein 2)	protein interactions	4133	80	2	19454	50	PRKACB,PRKAR2A
1.801e-02	-4.02	NEK1 (NIMA related kinase 1)	protein interactions	4750	80	2	19454	50	GSK3B,CAMK2D
1.818e-02	-4.01	kinase binding	molecular function	GO:0019900	780	6	18094	49	CBL,NBEA,GSK3B,RYR2,CACNB4,PRKAR2A
1.824e-02	-4.00	inflammatory response	biological process	GO:0006954	559	5	18204	50	PLD3,SLC18A2,SMPDL3B,ADCY8,DPEP1
1.832e-02	-4.00	PPP1CA (protein phosphatase 1 catalytic subunit alpha)	protein interactions	5499	598	5	19454	50	SHOC2,GSK3B,PRKACB,RYR2,PRKAR2A
1.834e-02	-4.00	Disinhibition of SNARE formation	REACTOME pathways	R-HSA-114516	5	1	10285	38	PRKCA
1.834e-02	-4.00	PKA-mediated phosphorylation of key metabolic factors	REACTOME pathways	R-HSA-163358	5	1	10285	38	PRKACB
1.843e-02	-3.99	DNMT3L (DNA methyltransferase 3 like)	protein interactions	29947	81	2	19454	50	RXRA,GSK3B
1.843e-02	-3.99	GRIP1 (glutamate receptor interacting protein 1)	protein interactions	23426	81	2	19454	50	RXRA,GRIA3
1.846e-02	-3.99	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	38	16828	47	PRKCA,PHACTR2,SLC18A2,SHOC2,ATP2A1,LRCH1,SMPDL3B,CBL,RXRA,SYT10,SLC16A14,PLCB1,CACNB4,PDE1A,PDE9A,PDE2A,ADCY8,CACNA1B,GRIA3,FOXD3,RAPSN,PRKACB,SLC39A6,CAMK2D,GUCY2F,RASGRF1,KCND2,KALRN,GUCY1A2,NR4A2,PLCE1,CELF3,RYR2,TIAM2,PDE4B,NBEA,GARNL3,ITPR1
1.850e-02	-3.99	Voltage-gated potassium channels. Chain C	gene3d domains	1.20.120.350	63	2	14470	48	KCND2,CACNA1B
1.852e-02	-3.99	actin-mediated cell contraction	biological process	GO:0070252	76	2	18204	50	CAMK2D,RYR2
1.866e-02	-3.98	MAPK3 (mitogen-activated protein kinase 3)	protein interactions	5595	396	4	19454	50	PRKCA,PLCB1,RXRA,NR4A2
1.875e-02	-3.98	RPEL_repeat	interpro domains	IPR004018	7	1	18521	50	PHACTR2
1.875e-02	-3.98	GAF	interpro domains	IPR003018	7	1	18521	50	PDE2A
1.875e-02	-3.98	GPHH_dom	interpro domains	IPR031649	7	1	18521	50	CACNA1B
1.875e-02	-3.98	PLipase_D/transphosphatidylase	interpro domains	IPR001736	7	1	18521	50	PLD3
1.875e-02	-3.98	RBD_dom	interpro domains	IPR003116	7	1	18521	50	TIAM2
1.875e-02	-3.98	VDCC_a1su_IQ	interpro domains	IPR014873	7	1	18521	50	CACNA1B
1.875e-02	-3.98	cAMP_dep_PK_reg_su_I/II_a/b	interpro domains	IPR003117	7	1	18521	50	PRKAR2A
1.878e-02	-3.97	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	6	16828	47	PRKCA,GUCY1A2,PRKACB,CAMK2D,GUCY2F,CBL
1.878e-02	-3.97	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	6	16828	47	PRKCA,GUCY1A2,CAMK2D,PRKACB,CBL,GUCY2F
1.880e-02	-3.97	Cocaine addiction	KEGG pathways	hsa05030	49	2	7161	31	SLC18A2,PRKACB
1.880e-02	-3.97	Cocaine addiction	KEGG pathways	ko05030	49	2	7161	31	PRKACB,SLC18A2
1.881e-02	-3.97	sphingomyelin phosphodiesterase activity	molecular function	GO:0004767	7	1	18094	49	SMPDL3B
1.881e-02	-3.97	oxo-acid-lyase activity	molecular function	GO:0016833	7	1	18094	49	NPL
1.881e-02	-3.97	TPR domain binding	molecular function	GO:0030911	7	1	18094	49	PDE2A
1.881e-02	-3.97	LBD domain binding	molecular function	GO:0050693	7	1	18094	49	RXRA
1.886e-02	-3.97	CCPG1 (cell cycle progression 1)	protein interactions	9236	82	2	19454	50	GRIA3,ATP2A1
1.886e-02	-3.97	CYP2S1 (cytochrome P450 family 2 subfamily S member 1)	protein interactions	29785	82	2	19454	50	PRKCA,SMPDL3B
1.887e-02	-3.97	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	46	16828	47	SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,SMPDL3B,CBL,NGB,PLD3,ATP2A1,KCNH6,PDE1A,SLC16A14,RXRA,SYT10,RAB37,PLCB1,CACNA1B,GRIA3,PDE9A,ADCY8,PDE2A,PRKACB,SLC39A6,CAMK2D,GUCY2F,RASGRF1,FOXD3,RAPSN,MRAS,KCND2,GUCY1A2,DPEP1,KALRN,TIAM2,PDE4B,NR4A2,CELF3,PLCE1,PRKAR2A,RYR2,GARNL3,ITPR1,RASD1,NPL,NBEA
1.892e-02	-3.97	gallbladder	COSMIC cancer mutations	gallbladder	2821	14	16828	47	PDE2A,ADCY8,PDE9A,KCND2,GUCY1A2,NBEA,LRCH1,ITPR1,CACNA1B,GRIA3,CBL,SLC16A14,GUCY2F,RASGRF1
1.892e-02	-3.97	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	14	16828	47	SLC16A14,GUCY2F,RASGRF1,GUCY1A2,NBEA,ADCY8,PDE2A,PDE9A,KCND2,CBL,GRIA3,LRCH1,ITPR1,CACNA1B
1.893e-02	-3.97	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	5	16828	47	RYR2,GUCY1A2,PLCB1,GRIA3,GARNL3
1.897e-02	-3.96	HOLI	smart domains	SM00430	48	2	9717	43	NR4A2,RXRA
1.898e-02	-3.96	positive regulation of small GTPase mediated signal transduction	biological process	GO:0051057	77	2	18204	50	SHOC2,RASGRF1
1.898e-02	-3.96	response to activity	biological process	GO:0014823	77	2	18204	50	CBL,RYR2
1.907e-02	-3.96	regulation of thyroid hormone mediated signaling pathway	biological process	GO:0002155	7	1	18204	50	RXRA
1.907e-02	-3.96	carbohydrate mediated signaling	biological process	GO:0009756	7	1	18204	50	ADCY8
1.907e-02	-3.96	cellular response to cGMP	biological process	GO:0071321	7	1	18204	50	PDE2A
1.907e-02	-3.96	histamine secretion	biological process	GO:0001821	7	1	18204	50	SLC18A2
1.907e-02	-3.96	regulation of monocyte extravasation	biological process	GO:2000437	7	1	18204	50	PLCB1
1.907e-02	-3.96	voluntary musculoskeletal movement	biological process	GO:0050882	7	1	18204	50	ITPR1
1.907e-02	-3.96	neurotransmitter loading into synaptic vesicle	biological process	GO:0098700	7	1	18204	50	SLC18A2
1.907e-02	-3.96	N-acetylneuraminate catabolic process	biological process	GO:0019262	7	1	18204	50	NPL
1.907e-02	-3.96	positive regulation of long-term synaptic depression	biological process	GO:1900454	7	1	18204	50	ADCY8
1.907e-02	-3.96	negative regulation of relaxation of muscle	biological process	GO:1901078	7	1	18204	50	PDE4B
1.907e-02	-3.96	cellular response to interleukin-3	biological process	GO:0036016	7	1	18204	50	GSK3B
1.907e-02	-3.96	positive regulation of protein localization to cilium	biological process	GO:1903566	7	1	18204	50	GSK3B
1.907e-02	-3.96	positive regulation of protein localization to centrosome	biological process	GO:1904781	7	1	18204	50	GSK3B
1.907e-02	-3.96	response to interleukin-3	biological process	GO:0036015	7	1	18204	50	GSK3B
1.912e-02	-3.96	RIIa	pfam domains	PF02197	7	1	17795	49	PRKAR2A
1.912e-02	-3.96	Ca_chan_IQ	pfam domains	PF08763	7	1	17795	49	CACNA1B
1.912e-02	-3.96	RPEL	pfam domains	PF02755	7	1	17795	49	PHACTR2
1.912e-02	-3.96	GAF	pfam domains	PF01590	7	1	17795	49	PDE2A
1.912e-02	-3.96	GPHH	pfam domains	PF16905	7	1	17795	49	CACNA1B
1.920e-02	-3.95	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	5	16828	47	RYR2,PLCB1,GUCY1A2,GARNL3,GRIA3
1.925e-02	-3.95	RHOB (ras homolog family member B)	protein interactions	388	832	6	19454	50	NBEA,PHACTR2,PLCB1,TIAM2,SLC39A6,MINK1
1.929e-02	-3.95	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	38	CAMK2D,ATP2A1
1.930e-02	-3.95	TBC1D5 (TBC1 domain family member 5)	protein interactions	9779	83	2	19454	50	NGB,CBL
1.953e-02	-3.94	Ovarian steroidogenesis	KEGG pathways	ko04913	50	2	7161	31	PRKACB,ADCY8
1.953e-02	-3.94	Ovarian steroidogenesis	KEGG pathways	hsa04913	50	2	7161	31	ADCY8,PRKACB
1.972e-02	-3.93	S_TK_X	smart domains	SM00133	49	2	9717	43	PRKCA,PRKACB
1.974e-02	-3.93	PPARA (peroxisome proliferator activated receptor alpha)	protein interactions	5465	84	2	19454	50	RXRA,PRKCA
1.974e-02	-3.93	TMEM185A (transmembrane protein 185A)	protein interactions	84548	84	2	19454	50	SMPDL3B,PRKCA
1.975e-02	-3.92	RETINOIDXR	prints domains	PR00545	4	1	5227	26	RXRA
1.975e-02	-3.92	LCACHANNELB	prints domains	PR01626	4	1	5227	26	CACNB4
1.985e-02	-3.92	response to hormone	biological process	GO:0009725	784	6	18204	50	NR4A2,GSK3B,RXRA,ADCY8,SHOC2,PLCB1
1.986e-02	-3.92	other	COSMIC cancer mutations	other	14843	46	16828	47	NPL,NBEA,RASD1,GARNL3,ITPR1,PRKAR2A,RYR2,CELF3,PLCE1,NR4A2,PDE4B,TIAM2,KALRN,GUCY1A2,DPEP1,KCND2,MRAS,RAPSN,FOXD3,RASGRF1,GUCY2F,CAMK2D,SLC39A6,PRKACB,PDE2A,PDE9A,ADCY8,GRIA3,CACNA1B,CACNB4,PLCB1,SYT10,RXRA,SLC16A14,PDE1A,KCNH6,ATP2A1,NGB,PLD3,CBL,SMPDL3B,LRCH1,PHACTR2,PRKCA,SHOC2,SLC18A2
1.996e-02	-3.91	caveola	cellular component	GO:0005901	83	2	19108	50	ADCY8,CBL
2.018e-02	-3.90	AKAP13 (A-kinase anchoring protein 13)	protein interactions	11214	85	2	19454	50	PRKAR2A,PRKCA
2.018e-02	-3.90	ABHD12 (abhydrolase domain containing 12, lysophospholipase)	protein interactions	26090	85	2	19454	50	ATP2A1,PLD3
2.018e-02	-3.90	positive regulation of GTPase activity	biological process	GO:0043547	211	3	18204	50	GSK3B,RASGRF1,TIAM2
2.027e-02	-3.90	Vibrio cholerae infection	KEGG pathways	hsa05110	51	2	7161	31	PRKACB,PRKCA
2.027e-02	-3.90	Vibrio cholerae infection	KEGG pathways	ko05110	51	2	7161	31	PRKCA,PRKACB
2.028e-02	-3.90	hand	COSMIC cancer mutations	hand	566	5	16828	47	PLCE1,ADCY8,KCND2,PDE4B,KCNH6
2.038e-02	-3.89	Marcks (myristoylated alanine rich protein kinase C substrate)	protein interactions	17118	8	1	19454	50	PRKCA
2.038e-02	-3.89	STON1 (stonin 1)	protein interactions	11037	8	1	19454	50	GSK3B
2.038e-02	-3.89	STOML1 (stomatin like 1)	protein interactions	9399	8	1	19454	50	SLC18A2
2.038e-02	-3.89	Prkca (protein kinase C, alpha)	protein interactions	24680	8	1	19454	50	PRKCA
2.038e-02	-3.89	NPL (N-acetylneuraminate pyruvate lyase)	protein interactions	80896	8	1	19454	50	NPL
2.038e-02	-3.89	CEP15 (centrosomal protein 15)	protein interactions	57415	8	1	19454	50	SMPDL3B
2.038e-02	-3.89	ATP9B (ATPase phospholipid transporting 9B (putative))	protein interactions	374868	8	1	19454	50	PDE2A
2.038e-02	-3.89	CD163 (CD163 molecule)	protein interactions	9332	8	1	19454	50	PRKCA
2.038e-02	-3.89	KBTBD3 (kelch repeat and BTB domain containing 3)	protein interactions	143879	8	1	19454	50	NGB
2.038e-02	-3.89	C10orf90 (chromosome 10 open reading frame 90)	protein interactions	118611	8	1	19454	50	GSK3B
2.038e-02	-3.89	TCN1 (transcobalamin 1)	protein interactions	6947	8	1	19454	50	CBL
2.038e-02	-3.89	Atm (ataxia telangiectasia mutated)	protein interactions	11920	8	1	19454	50	CBL
2.056e-02	-3.88	NRAGE signals death through JNK	REACTOME pathways	R-HSA-193648	60	2	10285	38	KALRN,TIAM2
2.063e-02	-3.88	SLC38A7 (solute carrier family 38 member 7)	protein interactions	55238	86	2	19454	50	PLD3,PDE2A
2.069e-02	-3.88	negative regulation of transferase activity	biological process	GO:0051348	213	3	18204	50	GSK3B,CBL,PRKAR2A
2.087e-02	-3.87	adult locomotory behavior	biological process	GO:0008344	81	2	18204	50	NR4A2,CACNB4
2.094e-02	-3.87	cellular response to inorganic substance	biological process	GO:0071241	214	3	18204	50	CAMK2D,ADCY8,DPEP1
2.095e-02	-3.87	regulation of actin filament-based process	biological process	GO:0032970	384	4	18204	50	ATP2A1,RYR2,CAMK2D,PDE4B
2.108e-02	-3.86	UBE2G2 (ubiquitin conjugating enzyme E2 G2)	protein interactions	7327	87	2	19454	50	PDE2A,CBL
2.108e-02	-3.86	EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1)	protein interactions	1978	87	2	19454	50	GSK3B,PRKCA
2.108e-02	-3.86	ENO3 (enolase 3)	protein interactions	2027	87	2	19454	50	CAMK2D,KALRN
2.118e-02	-3.85	RAS	smart domains	SM00173	134	3	9717	43	RASD1,RAB37,MRAS
2.121e-02	-3.85	GLI3 is processed to GLI3R by the proteasome	REACTOME pathways	R-HSA-5610785	61	2	10285	38	GSK3B,PRKACB
2.121e-02	-3.85	Degradation of GLI2 by the proteasome	REACTOME pathways	R-HSA-5610783	61	2	10285	38	PRKACB,GSK3B
2.128e-02	-3.85	apical plasma membrane	cellular component	GO:0016324	405	4	19108	50	AJM1,ADCY8,DPEP1,SLC39A6
2.135e-02	-3.85	granulocyte chemotaxis	biological process	GO:0071621	82	2	18204	50	PDE4B,DPEP1
2.139e-02	-3.84	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	11	16828	47	PRKAR2A,PRKCA,RASGRF1,SHOC2,PRKACB,GUCY1A2,MRAS,ADCY8,CBL,RASD1,ITPR1
2.139e-02	-3.84	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	11	16828	47	MRAS,ADCY8,GUCY1A2,ITPR1,RASD1,CBL,PRKCA,PRKAR2A,PRKACB,SHOC2,RASGRF1
2.140e-02	-3.84	PH-BEACH_dom	interpro domains	IPR023362	8	1	18521	50	NBEA
2.140e-02	-3.84	NO_sig/Golgi_transp_ligand-bd	interpro domains	IPR024096	8	1	18521	50	GUCY1A2
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY8
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY8
2.140e-02	-3.84	GAF-like_dom_sf	interpro domains	IPR029016	8	1	18521	50	PDE2A
2.146e-02	-3.84	purine nucleotide biosynthetic process	biological process	GO:0006164	216	3	18204	50	GUCY2F,ADCY8,GUCY1A2
2.146e-02	-3.84	sodium channel inhibitor activity	molecular function	GO:0019871	8	1	18094	49	CAMK2D
2.146e-02	-3.84	cyclic nucleotide-dependent protein kinase activity	molecular function	GO:0004690	8	1	18094	49	PRKACB
2.146e-02	-3.84	metallodipeptidase activity	molecular function	GO:0070573	8	1	18094	49	DPEP1
2.146e-02	-3.84	AMP-activated protein kinase activity	molecular function	GO:0004679	8	1	18094	49	PRKACB
2.146e-02	-3.84	GPI anchor binding	molecular function	GO:0034235	8	1	18094	49	DPEP1
2.146e-02	-3.84	nitrite reductase activity	molecular function	GO:0098809	8	1	18094	49	NGB
2.147e-02	-3.84	PLD	prosite domains	PS50035	6	1	12186	44	PLD3
2.152e-02	-3.84	MAPK family signaling cascades	REACTOME pathways	R-HSA-5683057	290	4	10285	38	CAMK2D,PRKACB,RASGRF1,KALRN
2.153e-02	-3.84	EDF1 (endothelial differentiation related factor 1)	protein interactions	8721	88	2	19454	50	PRKCA,RXRA
2.153e-02	-3.84	STROIDFINGER	prints domains	PR00047	46	2	5227	26	NR4A2,RXRA
2.157e-02	-3.84	FYN (FYN proto-oncogene, Src family tyrosine kinase)	protein interactions	2534	414	4	19454	50	CBL,ITPR1,PRKACB,KALRN
2.167e-02	-3.83	IFN-gamma pathway	Pathway Interaction DB	ifngpathway	40	2	2226	13	CBL,CAMK2D
2.175e-02	-3.83	phosphatidylinositol-4,5-bisphosphate binding	molecular function	GO:0005546	84	2	18094	49	PLCB1,SYT10
2.175e-02	-3.83	TMOD3 (tropomodulin 3)	protein interactions	29766	232	3	19454	50	PHACTR2,CBL,CAMK2D
2.175e-02	-3.83	TK1 (thymidine kinase 1)	protein interactions	7083	232	3	19454	50	RXRA,PLD3,TIAM2
2.177e-02	-3.83	cyclic-GMP-AMP transmembrane import across plasma membrane	biological process	GO:0140361	8	1	18204	50	SHOC2
2.177e-02	-3.83	mitotic nuclear membrane disassembly	biological process	GO:0007077	8	1	18204	50	PRKCA
2.177e-02	-3.83	cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:0036006	8	1	18204	50	PDE2A
2.177e-02	-3.83	mucosa-associated lymphoid tissue development	biological process	GO:0048537	8	1	18204	50	CACNB4
2.177e-02	-3.83	cellular response to vasopressin	biological process	GO:1904117	8	1	18204	50	PLCB1
2.177e-02	-3.83	diacylglycerol biosynthetic process	biological process	GO:0006651	8	1	18204	50	PLCE1
2.177e-02	-3.83	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	biological process	GO:1901030	8	1	18204	50	GSK3B
2.177e-02	-3.83	skeletal muscle acetylcholine-gated channel clustering	biological process	GO:0071340	8	1	18204	50	RAPSN
2.177e-02	-3.83	negative regulation of cAMP-dependent protein kinase activity	biological process	GO:2000480	8	1	18204	50	PRKAR2A
2.177e-02	-3.83	regulation of cardiac muscle cell action potential involved in regulation of contraction	biological process	GO:0098909	8	1	18204	50	CAMK2D
2.177e-02	-3.83	regulation of nitric oxide mediated signal transduction	biological process	GO:0010749	8	1	18204	50	GUCY1A2
2.177e-02	-3.83	negative regulation of endoplasmic reticulum calcium ion concentration	biological process	GO:0032471	8	1	18204	50	ATP2A1
2.177e-02	-3.83	catecholamine secretion	biological process	GO:0050432	8	1	18204	50	SLC18A2
2.177e-02	-3.83	response to vasopressin	biological process	GO:1904116	8	1	18204	50	PLCB1
2.177e-02	-3.83	icosanoid catabolic process	biological process	GO:1901523	8	1	18204	50	DPEP1
2.177e-02	-3.83	Peyer's patch development	biological process	GO:0048541	8	1	18204	50	CACNB4
2.182e-02	-3.82	Laminin_G_3	pfam domains	PF13385	8	1	17795	49	NBEA
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY8
2.184e-02	-3.82	positive regulation of ion transmembrane transporter activity	biological process	GO:0032414	83	2	18204	50	RYR2,ATP2A1
2.184e-02	-3.82	cardiac muscle contraction	biological process	GO:0060048	83	2	18204	50	CAMK2D,RYR2
2.184e-02	-3.82	positive regulation of calcium ion transmembrane transport	biological process	GO:1904427	83	2	18204	50	ATP2A1,RYR2
2.194e-02	-3.82	adenoma	COSMIC cancer mutations	adenoma	2873	14	16828	47	CACNA1B,LRCH1,CBL,KCND2,PDE2A,ADCY8,MRAS,GUCY1A2,KALRN,NPL,TIAM2,RASGRF1,PRKCA,SYT10
2.197e-02	-3.82	Cam-PDE 1 activation	REACTOME pathways	R-HSA-111957	6	1	10285	38	PDE1A
2.199e-02	-3.82	PLAA (phospholipase A2 activating protein)	protein interactions	9373	89	2	19454	50	CBL,ADCY8
2.200e-02	-3.82	CCNB1 (cyclin B1)	protein interactions	891	233	3	19454	50	LRCH1,NGB,ITPR1
2.213e-02	-3.81	synovial	COSMIC cancer mutations	synovial	8	1	16828	47	RYR2
2.213e-02	-3.81	bone-knee-chondrosarcoma-synovial	COSMIC cancer mutations	bone-knee-chondrosarcoma-synovial	8	1	16828	47	RYR2
2.219e-02	-3.81	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	11	16828	47	KCNH6,PDE1A,PDE4B,PLCE1,PLCB1,LRCH1,SMPDL3B,ADCY8,KCND2,GUCY1A2,ATP2A1
2.222e-02	-3.81	negative regulation of biological process	biological process	GO:0048519	5737	23	18204	50	CAMK2D,PRKAR2A,NR4A2,RXRA,PRKACB,CACNB4,PRKCA,SLC18A2,RYR2,PDE4B,SHOC2,PDE2A,PDE9A,DPEP1,PLCB1,CBL,RASD1,LRCH1,GSK3B,SMPDL3B,ITPR1,FOXD3,PLCE1
2.233e-02	-3.80	regulation of release of sequestered calcium ion into cytosol	biological process	GO:0051279	84	2	18204	50	CAMK2D,RYR2
2.242e-02	-3.80	STRDHORMONER	prints domains	PR00398	47	2	5227	26	RXRA,NR4A2
2.246e-02	-3.80	UXS1 (UDP-glucuronate decarboxylase 1)	protein interactions	80146	90	2	19454	50	DPEP1,PDE2A
2.250e-02	-3.79	apoptotic process	biological process	GO:0006915	1038	7	18204	50	NR4A2,RAPSN,GSK3B,ATP2A1,PRKCA,ITPR1,RYR2
2.257e-02	-3.79	Regulation of lipolysis in adipocytes	KEGG pathways	hsa04923	54	2	7161	31	PRKACB,ADCY8
2.286e-02	-3.78	LRR_BAC	smart domains	SM00364	53	2	9717	43	SHOC2,LRCH1
2.290e-02	-3.78	SLN (sarcolipin)	protein interactions	6588	9	1	19454	50	ATP2A1
2.290e-02	-3.78	ACR (acrosin)	protein interactions	49	9	1	19454	50	GSK3B
2.290e-02	-3.78	IQCG (IQ motif containing G)	protein interactions	84223	9	1	19454	50	GSK3B
2.290e-02	-3.78	AKAP3 (A-kinase anchoring protein 3)	protein interactions	10566	9	1	19454	50	PRKAR2A
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	PLD3
2.290e-02	-3.78	PDE1C (phosphodiesterase 1C)	protein interactions	5137	9	1	19454	50	PDE1A
2.290e-02	-3.78	FBXL21P (F-box and leucine rich repeat protein 21, pseudogene)	protein interactions	26223	9	1	19454	50	GSK3B
2.290e-02	-3.78	PKIB (cAMP-dependent protein kinase inhibitor beta)	protein interactions	5570	9	1	19454	50	PRKACB
2.290e-02	-3.78	SOBP (sine oculis binding protein homolog)	protein interactions	55084	9	1	19454	50	CELF3
2.290e-02	-3.78	STEAP2 (STEAP2 metalloreductase)	protein interactions	261729	9	1	19454	50	DPEP1
2.290e-02	-3.78	ADIRF (adipogenesis regulatory factor)	protein interactions	10974	9	1	19454	50	GSK3B
2.290e-02	-3.78	CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1)	protein interactions	55450	9	1	19454	50	CAMK2D
2.290e-02	-3.78	RDH8 (retinol dehydrogenase 8)	protein interactions	50700	9	1	19454	50	NBEA
2.292e-02	-3.78	ACVR1B (activin A receptor type 1B)	protein interactions	91	91	2	19454	50	RXRA,PRKACB
2.292e-02	-3.78	COQ5 (coenzyme Q5, methyltransferase)	protein interactions	84274	91	2	19454	50	DPEP1,SLC18A2
2.300e-02	-3.77	-	gene3d domains	6.10.250.2180	7	1	14470	48	CACNA1B
2.300e-02	-3.77	-	gene3d domains	6.10.250.2500	7	1	14470	48	CACNA1B
2.308e-02	-3.77	LAMP1 (lysosomal associated membrane protein 1)	protein interactions	3916	635	5	19454	50	SLC39A6,PRKAR2A,PLCB1,PLD3,NBEA
2.331e-02	-3.76	junctional sarcoplasmic reticulum membrane	cellular component	GO:0014701	9	1	19108	50	RYR2
2.331e-02	-3.76	flotillin complex	cellular component	GO:0016600	9	1	19108	50	CBL
2.350e-02	-3.75	HTLV-I infection	KEGG pathways	ko05166	256	4	7161	31	MRAS,PRKACB,ADCY8,GSK3B
2.350e-02	-3.75	HTLV-I infection	KEGG pathways	hsa05166	256	4	7161	31	GSK3B,PRKACB,ADCY8,MRAS
2.352e-02	-3.75	organic anion transport	biological process	GO:0015711	398	4	18204	50	CACNB4,SLC39A6,SLC16A14,SHOC2
2.357e-02	-3.75	positive regulation of intracellular signal transduction	biological process	GO:1902533	1048	7	18204	50	PRKCA,MINK1,PLCB1,GUCY1A2,SHOC2,CBL,RASGRF1
2.358e-02	-3.75	purine-containing compound biosynthetic process	biological process	GO:0072522	224	3	18204	50	ADCY8,GUCY2F,GUCY1A2
2.366e-02	-3.74	TRAF6 (TNF receptor associated factor 6)	protein interactions	7189	426	4	19454	50	RXRA,PRKACB,CBL,GSK3B
2.375e-02	-3.74	ANXA1 (annexin A1)	protein interactions	301	240	3	19454	50	GSK3B,NGB,SHOC2
2.387e-02	-3.74	ARHGEF12 (Rho guanine nucleotide exchange factor 12)	protein interactions	23365	93	2	19454	50	CBL,GSK3B
2.404e-02	-3.73	VDCCAlpha1	interpro domains	IPR002077	9	1	18521	50	CACNA1B
2.404e-02	-3.73	BEACH_dom	interpro domains	IPR000409	9	1	18521	50	NBEA
2.404e-02	-3.73	BEACH_dom_sf	interpro domains	IPR036372	9	1	18521	50	NBEA
2.412e-02	-3.72	7SK snRNA binding	molecular function	GO:0097322	9	1	18094	49	CELF3
2.412e-02	-3.72	calcium-dependent protein serine/threonine kinase activity	molecular function	GO:0009931	9	1	18094	49	PRKCA
2.412e-02	-3.72	5'-3' DNA exonuclease activity	molecular function	GO:0035312	9	1	18094	49	PLD3
2.412e-02	-3.72	P-type calcium transporter activity	molecular function	GO:0005388	9	1	18094	49	ATP2A1
2.412e-02	-3.72	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	28	16828	47	KALRN,DPEP1,ATP2A1,KCND2,PLD3,SMPDL3B,CBL,LRCH1,FOXD3,GUCY2F,SLC18A2,SLC39A6,NPL,GRIA3,ITPR1,RASD1,GARNL3,CACNA1B,RAB37,PLCE1,PRKAR2A,RYR2,SYT10,SLC16A14,PDE4B,KCNH6,PDE1A,TIAM2
2.422e-02	-3.72	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	49	GRIA3,CACNA1B
2.429e-02	-3.72	stomach	COSMIC cancer mutations	stomach	15550	47	16828	47	RAPSN,FOXD3,RASGRF1,GUCY2F,SLC39A6,CAMK2D,PRKACB,DPEP1,GUCY1A2,KALRN,KCND2,MRAS,RYR2,PRKAR2A,PLCE1,CELF3,NR4A2,PDE4B,TIAM2,NPL,NBEA,ITPR1,GARNL3,RASD1,PHACTR2,PRKCA,SHOC2,SLC18A2,ATP2A1,PLD3,NGB,CBL,SMPDL3B,LRCH1,CACNB4,PLCB1,RAB37,RXRA,SYT10,SLC16A14,PDE1A,KCNH6,ADCY8,PDE2A,PDE9A,GRIA3,CACNA1B
2.430e-02	-3.72	human chr9q34.3	chromosome location	human chr9q34.3	126	2	26134	50	AJM1,CACNA1B
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	GSK3B,PRKCA
2.436e-02	-3.71	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	33	16828	47	ITPR1,GARNL3,RASD1,NBEA,TIAM2,PRKAR2A,RYR2,CELF3,PLCE1,KCND2,MRAS,KALRN,DPEP1,CAMK2D,PRKACB,RASGRF1,GUCY2F,FOXD3,CACNA1B,GRIA3,PDE9A,ADCY8,KCNH6,SLC16A14,RXRA,PLCB1,RAB37,LRCH1,CBL,PLD3,ATP2A1,PRKCA,PHACTR2
2.446e-02	-3.71	maintenance of postsynaptic specialization structure	biological process	GO:0098880	9	1	18204	50	RAPSN
2.446e-02	-3.71	regulation of protein localization to nucleolus	biological process	GO:1904749	9	1	18204	50	CACNB4
2.446e-02	-3.71	zinc ion import across plasma membrane	biological process	GO:0071578	9	1	18204	50	SLC39A6
2.446e-02	-3.71	negative regulation of cellular extravasation	biological process	GO:0002692	9	1	18204	50	PLCB1
2.446e-02	-3.71	glutathione catabolic process	biological process	GO:0006751	9	1	18204	50	DPEP1
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR2
2.446e-02	-3.71	regulation of type B pancreatic cell development	biological process	GO:2000074	9	1	18204	50	GSK3B
2.446e-02	-3.71	response to cGMP	biological process	GO:0070305	9	1	18204	50	PDE2A
2.446e-02	-3.71	negative regulation of glycogen biosynthetic process	biological process	GO:0045719	9	1	18204	50	GSK3B
2.446e-02	-3.71	cAMP catabolic process	biological process	GO:0006198	9	1	18204	50	PDE4B
2.446e-02	-3.71	G protein-coupled opioid receptor signaling pathway	biological process	GO:0038003	9	1	18204	50	ADCY8
2.446e-02	-3.71	dopamine biosynthetic process	biological process	GO:0042416	9	1	18204	50	NR4A2
2.446e-02	-3.71	peroxisome proliferator activated receptor signaling pathway	biological process	GO:0035357	9	1	18204	50	RXRA
2.446e-02	-3.71	serotonin uptake	biological process	GO:0051610	9	1	18204	50	SLC18A2
2.446e-02	-3.71	negative regulation of protein acetylation	biological process	GO:1901984	9	1	18204	50	GSK3B
2.446e-02	-3.71	negative regulation of cAMP-mediated signaling	biological process	GO:0043951	9	1	18204	50	PDE2A
2.446e-02	-3.71	interleukin-12-mediated signaling pathway	biological process	GO:0035722	9	1	18204	50	PLCB1
2.452e-02	-3.71	Beach	pfam domains	PF02138	9	1	17795	49	NBEA
2.452e-02	-3.71	NPAS1 (neuronal PAS domain protein 1)	protein interactions	4861	243	3	19454	50	PRKACB,CAMK2D,PDE4B
2.456e-02	-3.71	pancreas-other-adenoma	COSMIC cancer mutations	pancreas-other-adenoma	224	3	16828	47	PRKCA,MRAS,CBL
2.458e-02	-3.71	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	16	16828	47	DPEP1,GUCY2F,RASGRF1,ITPR1,NBEA,PDE9A,ADCY8,PDE2A,RAB37,PLCB1,PLCE1,CELF3,RYR2,CACNB4,RXRA,SYT10
2.459e-02	-3.71	human chrXq25	chromosome location	human chrXq25	13	1	26134	50	GRIA3
2.462e-02	-3.70	zinc ion binding	molecular function	GO:0008270	836	6	18094	49	NR4A2,SMPDL3B,RXRA,DPEP1,PDE2A,PRKCA
2.463e-02	-3.70	HATPASE	prints domains	PR00120	5	1	5227	26	ATP2A1
2.468e-02	-3.70	Schaffer collateral - CA1 synapse	cellular component	GO:0098685	93	2	19108	50	ADCY8,ITPR1
2.468e-02	-3.70	immune response-activating cell surface receptor signaling pathway	biological process	GO:0002429	228	3	18204	50	PDE4B,SLC39A6,CACNB4
2.470e-02	-3.70	regulation of secretion	biological process	GO:0051046	605	5	18204	50	PLCB1,SYT10,ADCY8,CACNB4,ITPR1
2.475e-02	-3.70	SMAD3 (SMAD family member 3)	protein interactions	4088	432	4	19454	50	PRKAR2A,GSK3B,CBL,LRCH1
2.483e-02	-3.70	PNPLA6 (patatin like phospholipase domain containing 6)	protein interactions	10908	95	2	19454	50	CAMK2D,PLD3
2.487e-02	-3.69	transport vesicle membrane	cellular component	GO:0030658	240	3	19108	50	ITPR1,SYT10,SLC18A2
2.498e-02	-3.69	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	10	16828	47	GRIA3,GARNL3,CACNA1B,NBEA,GUCY2F,KCNH6,TIAM2,PDE1A,RYR2,RXRA
2.498e-02	-3.69	functioning	COSMIC cancer mutations	functioning	1803	10	16828	47	GARNL3,CACNA1B,GRIA3,NBEA,KCNH6,TIAM2,PDE1A,GUCY2F,RXRA,RYR2
2.501e-02	-3.69	RBD	prosite domains	PS50898	7	1	12186	44	TIAM2
2.501e-02	-3.69	RPEL	prosite domains	PS51073	7	1	12186	44	PHACTR2
2.505e-02	-3.69	SCRIB (scribble planar cell polarity protein)	protein interactions	23513	245	3	19454	50	GSK3B,GUCY1A2,PRKCA
2.511e-02	-3.68	MFS_dom	interpro domains	IPR020846	91	2	18521	50	SLC16A14,SLC18A2
2.514e-02	-3.68	exocytic vesicle	cellular component	GO:0070382	241	3	19108	50	SYT10,SLC18A2,PDE4B
2.532e-02	-3.68	GNG12 (G protein subunit gamma 12)	protein interactions	55970	96	2	19454	50	GSK3B,CBL
2.532e-02	-3.68	HOMER1 (homer scaffold protein 1)	protein interactions	9456	96	2	19454	50	RYR2,ITPR1
2.538e-02	-3.67	Golgi apparatus	cellular component	GO:0005794	1645	9	19108	50	PDE2A,PDE9A,CBL,NBEA,PLD3,RAPSN,MINK1,RAB37,PLCE1
2.539e-02	-3.67	epithelial to mesenchymal transition	biological process	GO:0001837	90	2	18204	50	SLC39A6,GSK3B
2.541e-02	-3.67	HNMT (histamine N-methyltransferase)	protein interactions	3176	10	1	19454	50	CAMK2D
2.541e-02	-3.67	YJEFN3 (YjeF N-terminal domain containing 3)	protein interactions	374887	10	1	19454	50	NBEA
2.541e-02	-3.67	KCNH4 (potassium voltage-gated channel subfamily H member 4)	protein interactions	23415	10	1	19454	50	KCNH6
2.541e-02	-3.67	ZNF135 (zinc finger protein 135)	protein interactions	7694	10	1	19454	50	GSK3B
2.541e-02	-3.67	BANK1 (B cell scaffold protein with ankyrin repeats 1)	protein interactions	55024	10	1	19454	50	ITPR1
2.541e-02	-3.67	GNAT1 (G protein subunit alpha transducin 1)	protein interactions	2779	10	1	19454	50	CBL
2.541e-02	-3.67	PPY (pancreatic polypeptide)	protein interactions	5539	10	1	19454	50	PRKCA
2.541e-02	-3.67	GUCA1B (guanylate cyclase activator 1B)	protein interactions	2979	10	1	19454	50	GUCY2F
2.541e-02	-3.67	SLC35A3 (solute carrier family 35 member A3)	protein interactions	23443	10	1	19454	50	PDE2A
2.544e-02	-3.67	cell leading edge	cellular component	GO:0031252	428	4	19108	50	PDE9A,TIAM2,PLCE1,SLC39A6
2.555e-02	-3.67	organelle membrane	cellular component	GO:0031090	3742	16	19108	50	ATP2A1,PDE2A,GUCY2F,SLC18A2,PLD3,PRKCA,RAB37,CAMK2D,PLCE1,PLCB1,RYR2,SYT10,GRIA3,ITPR1,ADCY8,PHACTR2
2.559e-02	-3.67	Phase 1 - inactivation of fast Na+ channels	REACTOME pathways	R-HSA-5576894	7	1	10285	38	KCND2
2.579e-02	-3.66	Non-small cell lung cancer	KEGG pathways	ko05223	58	2	7161	31	RXRA,PRKCA
2.579e-02	-3.66	Non-small cell lung cancer	KEGG pathways	hsa05223	58	2	7161	31	RXRA,PRKCA
2.581e-02	-3.66	SNTA1 (syntrophin alpha 1)	protein interactions	6640	97	2	19454	50	GUCY1A2,RYR2
2.581e-02	-3.66	ATL2 (atlastin GTPase 2)	protein interactions	64225	97	2	19454	50	DPEP1,ATP2A1
2.587e-02	-3.65	nucleotide-activated protein kinase complex	cellular component	GO:0031588	10	1	19108	50	PRKAR2A
2.605e-02	-3.65	SSR1 (signal sequence receptor subunit 1)	protein interactions	6745	439	4	19454	50	ATP2A1,GSK3B,CAMK2D,ITPR1
2.612e-02	-3.65	VPS35 (VPS35 retromer complex component)	protein interactions	55737	249	3	19454	50	ATP2A1,GSK3B,CBL
2.624e-02	-3.64	-	gene3d domains	1.10.1200.260	8	1	14470	48	KCNH6
2.624e-02	-3.64	-	gene3d domains	3.30.450.40	8	1	14470	48	PDE2A
2.627e-02	-3.64	RIIa	smart domains	SM00394	6	1	9717	43	PRKAR2A
2.627e-02	-3.64	PLDc	smart domains	SM00155	6	1	9717	43	PLD3
2.628e-02	-3.64	protein phosphatase regulator activity	molecular function	GO:0019888	93	2	18094	49	PHACTR2,SHOC2
2.631e-02	-3.64	GNAO1 (G protein subunit alpha o1)	protein interactions	2775	98	2	19454	50	NGB,CACNA1B
2.631e-02	-3.64	CBFB (core-binding factor subunit beta)	protein interactions	865	98	2	19454	50	CBL,SMPDL3B
2.631e-02	-3.64	PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2)	protein interactions	5636	98	2	19454	50	PRKCA,CBL
2.644e-02	-3.63	actin filament-based process	biological process	GO:0030029	616	5	18204	50	PHACTR2,MINK1,MRAS,CAMK2D,RYR2
2.646e-02	-3.63	human chr3p26.1	chromosome location	human chr3p26.1	14	1	26134	50	ITPR1
2.656e-02	-3.63	VAPA (VAMP associated protein A)	protein interactions	9218	659	5	19454	50	PDE2A,PRKACB,ATP2A1,PRKCA,NGB
2.671e-02	-3.62	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	91	2	16828	47	RAPSN,PDE9A
2.676e-02	-3.62	single-stranded DNA exodeoxyribonuclease activity	molecular function	GO:0008297	10	1	18094	49	PLD3
2.676e-02	-3.62	cAMP-dependent protein kinase inhibitor activity	molecular function	GO:0004862	10	1	18094	49	PRKAR2A
2.676e-02	-3.62	calcium-dependent protein kinase activity	molecular function	GO:0010857	10	1	18094	49	PRKCA
2.677e-02	-3.62	spleen	COSMIC cancer mutations	spleen	408	4	16828	47	PDE1A,KCNH6,PRKACB,PHACTR2
2.680e-02	-3.62	TLCD4 (TLC domain containing 4)	protein interactions	148534	99	2	19454	50	DPEP1,SLC18A2
2.680e-02	-3.62	B3GAT3 (beta-1,3-glucuronyltransferase 3)	protein interactions	26229	99	2	19454	50	PDE2A,PLD3
2.699e-02	-3.61	regulation of muscle cell apoptotic process	biological process	GO:0010660	93	2	18204	50	CAMK2D,PDE1A
2.706e-02	-3.61	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	8	16828	47	ADCY8,KCND2,KALRN,SYT10,PRKCA,SHOC2,PDE1A,RASGRF1
2.714e-02	-3.61	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	50	PRKACB
2.714e-02	-3.61	neuronal action potential propagation	biological process	GO:0019227	10	1	18204	50	CACNB4
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR2
2.714e-02	-3.61	guanine nucleotide transmembrane transport	biological process	GO:1903790	10	1	18204	50	SHOC2
2.714e-02	-3.61	positive regulation of lipopolysaccharide-mediated signaling pathway	biological process	GO:0031666	10	1	18204	50	PRKCA
2.714e-02	-3.61	regulation of postsynaptic cytosolic calcium ion concentration	biological process	GO:0099566	10	1	18204	50	ITPR1
2.714e-02	-3.61	negative regulation of glycogen metabolic process	biological process	GO:0070874	10	1	18204	50	GSK3B
2.714e-02	-3.61	negative regulation of glial cell apoptotic process	biological process	GO:0034351	10	1	18204	50	PRKCA
2.714e-02	-3.61	leukotriene D4 metabolic process	biological process	GO:1901748	10	1	18204	50	DPEP1
2.714e-02	-3.61	regulation of dopaminergic neuron differentiation	biological process	GO:1904338	10	1	18204	50	GSK3B
2.714e-02	-3.61	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	50	ADCY8
2.714e-02	-3.61	action potential propagation	biological process	GO:0098870	10	1	18204	50	CACNB4
2.714e-02	-3.61	regulation of opsin-mediated signaling pathway	biological process	GO:0022400	10	1	18204	50	GUCY2F
2.714e-02	-3.61	regulation of vitamin D receptor signaling pathway	biological process	GO:0070562	10	1	18204	50	RXRA
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	GSK3B
2.714e-02	-3.61	histamine transport	biological process	GO:0051608	10	1	18204	50	SLC18A2
2.714e-02	-3.61	desmosome organization	biological process	GO:0002934	10	1	18204	50	PRKCA
2.715e-02	-3.61	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	19	16828	47	KALRN,MRAS,PLD3,CBL,FOXD3,PRKCA,GUCY2F,RASGRF1,PRKACB,CAMK2D,GRIA3,ITPR1,RASD1,PLCB1,RAB37,PLCE1,RYR2,PRKAR2A,PDE1A
2.717e-02	-3.61	MYH9 (myosin heavy chain 9)	protein interactions	4627	663	5	19454	50	NGB,RXRA,PRKAR2A,CBL,GSK3B
2.719e-02	-3.60	transport vesicle	cellular component	GO:0030133	437	4	19108	50	PDE4B,ITPR1,SYT10,SLC18A2
2.720e-02	-3.60	PAS_9	pfam domains	PF13426	10	1	17795	49	KCNH6
2.720e-02	-3.60	Rap_GAP	pfam domains	PF02145	10	1	17795	49	GARNL3
2.731e-02	-3.60	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	50	CACNA1B,GSK3B
2.738e-02	-3.60	multicellular organismal process	biological process	GO:0032501	6177	24	18204	50	FOXD3,PLCE1,MINK1,GUCY2F,ITPR1,SYT10,CBL,GSK3B,RASGRF1,ATP2A1,KCND2,ADCY8,PLCB1,KALRN,SLC39A6,PRKCA,CACNB4,PDE4B,RYR2,SLC18A2,PDE2A,NR4A2,PRKACB,CAMK2D
2.752e-02	-3.59	regulation of calcium-mediated signaling	biological process	GO:0050848	94	2	18204	50	ITPR1,GSK3B
2.756e-02	-3.59	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	biological process	GO:0007188	238	3	18204	50	PDE2A,ADCY8,PRKACB
2.756e-02	-3.59	muscle contraction	biological process	GO:0006936	238	3	18204	50	KCND2,RYR2,CAMK2D
2.759e-02	-3.59	genital_tract-extragonadal-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	genital_tract-extragonadal-germ_cell_tumour-non_seminoma	10	1	16828	47	CBL
2.780e-02	-3.58	PPP1CB (protein phosphatase 1 catalytic subunit beta)	protein interactions	5500	448	4	19454	50	SHOC2,RYR2,PRKAR2A,GSK3B
2.780e-02	-3.58	aldosterone_producing	COSMIC cancer mutations	aldosterone_producing	93	2	16828	47	PDE9A,RAPSN
2.781e-02	-3.58	oesophagus	COSMIC cancer mutations	oesophagus	14970	46	16828	47	SLC18A2,SHOC2,PHACTR2,PRKCA,SMPDL3B,CBL,LRCH1,ATP2A1,NGB,KCNH6,PDE1A,RAB37,PLCB1,CACNB4,SYT10,RXRA,SLC16A14,GRIA3,CACNA1B,PDE2A,ADCY8,PDE9A,GUCY2F,RASGRF1,PRKACB,SLC39A6,CAMK2D,RAPSN,FOXD3,KALRN,DPEP1,GUCY1A2,MRAS,KCND2,PDE4B,TIAM2,PLCE1,CELF3,RYR2,PRKAR2A,NR4A2,GARNL3,RASD1,ITPR1,NBEA,NPL
2.789e-02	-3.58	RAB	smart domains	SM00175	149	3	9717	43	RAB37,RASD1,MRAS
2.792e-02	-3.58	TMEM53 (transmembrane protein 53)	protein interactions	79639	11	1	19454	50	PRKCA
2.792e-02	-3.58	ITPKA (inositol-trisphosphate 3-kinase A)	protein interactions	3706	11	1	19454	50	PRKCA
2.792e-02	-3.58	LAT2 (linker for activation of T cells family member 2)	protein interactions	7462	11	1	19454	50	CBL
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	ITPR1
2.792e-02	-3.58	GRIP2 (glutamate receptor interacting protein 2)	protein interactions	80852	11	1	19454	50	GRIA3
2.792e-02	-3.58	CACNA1D (calcium voltage-gated channel subunit alpha1 D)	protein interactions	776	11	1	19454	50	RYR2
2.792e-02	-3.58	PKIG (cAMP-dependent protein kinase inhibitor gamma)	protein interactions	11142	11	1	19454	50	PRKACB
2.792e-02	-3.58	CD38 (CD38 molecule)	protein interactions	952	11	1	19454	50	CBL
2.792e-02	-3.58	KIF4B (kinesin family member 4B)	protein interactions	285643	11	1	19454	50	CBL
2.792e-02	-3.58	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	1	19454	50	PRKCA
2.808e-02	-3.57	programmed cell death	biological process	GO:0012501	1087	7	18204	50	GSK3B,ATP2A1,RAPSN,NR4A2,RYR2,ITPR1,PRKCA
2.823e-02	-3.57	-	gene3d domains	2.80.10.50	79	2	14470	48	ITPR1,RYR2
2.832e-02	-3.56	RABGGTB (Rab geranylgeranyltransferase subunit beta)	protein interactions	5876	102	2	19454	50	RAB37,PRKACB
2.832e-02	-3.56	FASLG (Fas ligand)	protein interactions	356	102	2	19454	50	CACNB4,KALRN
2.832e-02	-3.56	CACNA1A (calcium voltage-gated channel subunit alpha1 A)	protein interactions	773	102	2	19454	50	KALRN,CACNB4
2.832e-02	-3.56	TMX3 (thioredoxin related transmembrane protein 3)	protein interactions	54495	102	2	19454	50	PDE2A,ATP2A1
2.839e-02	-3.56	RASTRNSFRMNG	prints domains	PR00449	135	3	5227	26	MRAS,RASD1,RAB37
2.846e-02	-3.56	exocytosis	biological process	GO:0006887	241	3	18204	50	CBL,SLC18A2,SYT10
2.853e-02	-3.56	PH_BEACH	prosite domains	PS51783	8	1	12186	44	NBEA
2.858e-02	-3.56	cell death	biological process	GO:0008219	1091	7	18204	50	NR4A2,RAPSN,ATP2A1,GSK3B,ITPR1,PRKCA,RYR2
2.859e-02	-3.55	GJD3 (gap junction protein delta 3)	protein interactions	125111	452	4	19454	50	MINK1,ITPR1,SLC39A6,PLD3
2.862e-02	-3.55	cellular response to monosaccharide stimulus	biological process	GO:0071326	96	2	18204	50	ADCY8,PLCB1
2.862e-02	-3.55	granulocyte migration	biological process	GO:0097530	96	2	18204	50	DPEP1,PDE4B
2.873e-02	-3.55	PH-like_dom_sf	interpro domains	IPR011993	431	4	18521	50	TIAM2,NBEA,RASGRF1,KALRN
2.884e-02	-3.55	RTN1 (reticulon 1)	protein interactions	6252	103	2	19454	50	ATP2A1,GSK3B
2.884e-02	-3.55	TXNRD1 (thioredoxin reductase 1)	protein interactions	7296	103	2	19454	50	GSK3B,CBL
2.889e-02	-3.54	Protein-protein interactions at synapses	REACTOME pathways	R-HSA-6794362	72	2	10285	38	SYT10,GRIA3
2.917e-02	-3.53	positive regulation of JNK cascade	biological process	GO:0046330	97	2	18204	50	MINK1,PLCB1
2.919e-02	-3.53	HuR (ELAVL1) binds and stabilizes mRNA	REACTOME pathways	R-HSA-450520	8	1	10285	38	PRKCA
2.919e-02	-3.53	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME pathways	R-HSA-434316	8	1	10285	38	PLCB1
2.919e-02	-3.53	Free fatty acids regulate insulin secretion	REACTOME pathways	R-HSA-400451	8	1	10285	38	PLCB1
2.919e-02	-3.53	Synthesis of PG	REACTOME pathways	R-HSA-1483148	8	1	10285	38	PLD3
2.920e-02	-3.53	Longevity regulating pathway - multiple species	KEGG pathways	ko04213	62	2	7161	31	ADCY8,PRKACB
2.920e-02	-3.53	Longevity regulating pathway - multiple species	KEGG pathways	hsa04213	62	2	7161	31	ADCY8,PRKACB
2.920e-02	-3.53	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	4	19454	50	PRKCA,KALRN,MINK1,CBL
2.931e-02	-3.53	Rap/Ran_GAP_dom	interpro domains	IPR000331	11	1	18521	50	GARNL3
2.931e-02	-3.53	Solute-binding_3/MltF_N	interpro domains	IPR001638	11	1	18521	50	GRIA3
2.931e-02	-3.53	Rap/Ran-GAP_sf	interpro domains	IPR035974	11	1	18521	50	GARNL3
2.940e-02	-3.53	phosphatidylinositol 3-kinase regulatory subunit binding	molecular function	GO:0036312	11	1	18094	49	CBL
2.940e-02	-3.53	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	49	RAPSN
2.940e-02	-3.53	histone H3 kinase activity	molecular function	GO:0140996	11	1	18094	49	PRKCA
2.947e-02	-3.52	BEACH domain	gene3d domains	1.10.1540.10	9	1	14470	48	NBEA
2.949e-02	-3.52	CAMPKINASE	prints domains	PR00103	6	1	5227	26	PRKAR2A
2.950e-02	-3.52	voltage-gated potassium channel activity	molecular function	GO:0005249	99	2	18094	49	KCND2,KCNH6
2.964e-02	-3.52	arm	COSMIC cancer mutations	arm	1331	8	16828	47	KALRN,KCND2,ADCY8,SYT10,PRKCA,RASGRF1,PDE1A,SHOC2
2.967e-02	-3.52	D-myo-inositol-5-phosphate metabolism	BIOCYC pathways	META_PWY-6367	9	1	902	3	PLCE1
2.981e-02	-3.51	positive regulation of acrosome reaction	biological process	GO:2000344	11	1	18204	50	PLCB1
2.981e-02	-3.51	interleukin-15-mediated signaling pathway	biological process	GO:0035723	11	1	18204	50	PLCB1
2.981e-02	-3.51	amine transport	biological process	GO:0015837	11	1	18204	50	SLC18A2
2.981e-02	-3.51	positive regulation of synaptic plasticity	biological process	GO:0031915	11	1	18204	50	ADCY8
2.981e-02	-3.51	positive regulation of mitochondrial calcium ion concentration	biological process	GO:0051561	11	1	18204	50	ATP2A1
2.981e-02	-3.51	egg activation	biological process	GO:0007343	11	1	18204	50	PLCB1
2.981e-02	-3.51	guanine nucleotide transport	biological process	GO:0001408	11	1	18204	50	SHOC2
2.981e-02	-3.51	ER overload response	biological process	GO:0006983	11	1	18204	50	GSK3B
2.981e-02	-3.51	regulation of protein localization to cilium	biological process	GO:1903564	11	1	18204	50	GSK3B
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR2
2.981e-02	-3.51	cyclic nucleotide transport	biological process	GO:0070729	11	1	18204	50	SHOC2
2.981e-02	-3.51	receptor guanylyl cyclase signaling pathway	biological process	GO:0007168	11	1	18204	50	GUCY2F
2.981e-02	-3.51	regulation of cGMP-mediated signaling	biological process	GO:0010752	11	1	18204	50	PDE2A
2.981e-02	-3.51	cellular response to interleukin-12	biological process	GO:0071349	11	1	18204	50	PLCB1
2.981e-02	-3.51	cellular response to interleukin-15	biological process	GO:0071350	11	1	18204	50	PLCB1
2.985e-02	-3.51	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	47	NR4A2,PRKCA,GUCY1A2,PRKACB,CAMK2D,GUCY2F
2.985e-02	-3.51	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	47	GUCY1A2,PRKCA,NR4A2,GUCY2F,CAMK2D,PRKACB
2.988e-02	-3.51	Uso1 (USO1 vesicle docking factor)	protein interactions	56041	105	2	19454	50	PRKAR2A,PRKACB
2.988e-02	-3.51	EPS8 (EGFR pathway substrate 8, signaling adaptor)	protein interactions	2059	105	2	19454	50	CBL,PDE2A
2.988e-02	-3.51	SBP_bac_3	pfam domains	PF00497	11	1	17795	49	GRIA3
2.990e-02	-3.51	response to lipid	biological process	GO:0033993	862	6	18204	50	CBL,RXRA,GSK3B,ADCY8,PDE4B,PLCB1
3.007e-02	-3.50	Synaptic vesicle cycle	KEGG pathways	ko04721	63	2	7161	31	SLC18A2,CACNA1B
3.007e-02	-3.50	Synaptic vesicle cycle	KEGG pathways	hsa04721	63	2	7161	31	CACNA1B,SLC18A2
3.018e-02	-3.50	human chr2q24.1	chromosome location	human chr2q24.1	16	1	26134	50	NR4A2
3.023e-02	-3.50	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	28	SLC18A2,CACNA1B
3.028e-02	-3.50	heart contraction	biological process	GO:0060047	99	2	18204	50	CAMK2D,RYR2
3.028e-02	-3.50	regulation of signaling receptor activity	biological process	GO:0010469	99	2	18204	50	CBL,MINK1
3.028e-02	-3.50	activation of GTPase activity	biological process	GO:0090630	99	2	18204	50	TIAM2,RASGRF1
3.040e-02	-3.49	H3-3B (H3.3 histone B)	protein interactions	3021	106	2	19454	50	GSK3B,PRKACB
3.040e-02	-3.49	PTN (pleiotrophin)	protein interactions	5764	106	2	19454	50	GSK3B,CACNB4
3.042e-02	-3.49	GRTP1 (growth hormone regulated TBC protein 1)	protein interactions	79774	12	1	19454	50	ATP2A1
3.042e-02	-3.49	TM7SF2 (transmembrane 7 superfamily member 2)	protein interactions	7108	12	1	19454	50	PLD3
3.042e-02	-3.49	GCOM1 (GCOM1, MYZAP-POLR2M combined locus)	protein interactions	145781	12	1	19454	50	CBL
3.042e-02	-3.49	ZNF843 (zinc finger protein 843)	protein interactions	283933	12	1	19454	50	CAMK2D
3.042e-02	-3.49	ROBO4 (roundabout guidance receptor 4)	protein interactions	54538	12	1	19454	50	RXRA
3.042e-02	-3.49	TCN2 (transcobalamin 2)	protein interactions	6948	12	1	19454	50	CBL
3.042e-02	-3.49	Ctnnbl1 (catenin, beta like 1)	protein interactions	66642	12	1	19454	50	PRKCA
3.042e-02	-3.49	ARMCX4 (armadillo repeat containing X-linked 4)	protein interactions	100131755	12	1	19454	50	PRKACB
3.042e-02	-3.49	HNRNPCL3 (heterogeneous nuclear ribonucleoprotein C like 3)	protein interactions	649330	12	1	19454	50	MINK1
3.042e-02	-3.49	IGKV1-5 (immunoglobulin kappa variable 1-5)	protein interactions	28299	12	1	19454	50	NGB
3.042e-02	-3.49	PEAK3 (PEAK family member 3)	protein interactions	374872	12	1	19454	50	CBL
3.042e-02	-3.49	XK (X-linked Kx blood group antigen, Kell and VPS13A binding protein)	protein interactions	7504	12	1	19454	50	PRKCA
3.042e-02	-3.49	LEAP2 (liver enriched antimicrobial peptide 2)	protein interactions	116842	12	1	19454	50	SMPDL3B
3.042e-02	-3.49	REM1 (RRAD and GEM like GTPase 1)	protein interactions	28954	12	1	19454	50	CACNB4
3.042e-02	-3.49	HSP90B2P (heat shock protein 90 beta family member 2, pseudogene)	protein interactions	7190	12	1	19454	50	PLD3
3.053e-02	-3.49	TCR signaling in naive CD8+ T cells	Pathway Interaction DB	cd8tcrpathway	48	2	2226	13	PRKCA,CBL
3.058e-02	-3.49	Ca_chan_IQ	smart domains	SM01062	7	1	9717	43	CACNA1B
3.058e-02	-3.49	RPEL	smart domains	SM00707	7	1	9717	43	PHACTR2
3.058e-02	-3.49	RBD	smart domains	SM00455	7	1	9717	43	TIAM2
3.058e-02	-3.49	GAF	smart domains	SM00065	7	1	9717	43	PDE2A
3.062e-02	-3.49	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	2	16828	47	SMPDL3B,PLCB1
3.072e-02	-3.48	OGT (O-linked N-acetylglucosamine (GlcNAc) transferase)	protein interactions	8473	927	6	19454	50	CAMK2D,GSK3B,PRKAR2A,SMPDL3B,PLD3,SHOC2
3.077e-02	-3.48	face	COSMIC cancer mutations	face	2139	11	16828	47	PLCB1,PLCE1,PDE4B,PDE1A,KCNH6,ATP2A1,GUCY1A2,KCND2,ADCY8,SMPDL3B,LRCH1
3.078e-02	-3.48	protein domain specific binding	molecular function	GO:0019904	651	5	18094	49	RXRA,CBL,ITPR1,PDE2A,PRKAR2A
3.079e-02	-3.48	regulation of protein transport	biological process	GO:0051223	433	4	18204	50	GSK3B,PLCB1,ITPR1,ADCY8
3.085e-02	-3.48	response to alkaloid	biological process	GO:0043279	100	2	18204	50	RYR2,ADCY8
3.096e-02	-3.48	Glioma	KEGG pathways	ko05214	64	2	7161	31	CAMK2D,PRKCA
3.096e-02	-3.48	Glioma	KEGG pathways	hsa05214	64	2	7161	31	PRKCA,CAMK2D
3.096e-02	-3.48	clathrin-sculpted vesicle	cellular component	GO:0060198	12	1	19108	50	SLC18A2
3.096e-02	-3.48	beta-catenin destruction complex	cellular component	GO:0030877	12	1	19108	50	GSK3B
3.117e-02	-3.47	modified amino acid binding	molecular function	GO:0072341	102	2	18094	49	DPEP1,SYT10
3.130e-02	-3.46	organonitrogen compound metabolic process	biological process	GO:1901564	4594	19	18204	50	PDE9A,KALRN,PRKCA,CACNB4,PDE4B,PDE2A,NR4A2,PRKACB,CAMK2D,GUCY1A2,PDE1A,NPL,MINK1,SMPDL3B,GUCY2F,CBL,GSK3B,DPEP1,ADCY8
3.131e-02	-3.46	Wnt Signaling Pathway Netpath	WikiPathways	WP363	53	2	5310	28	PRKCA,GSK3B
3.137e-02	-3.46	amide binding	molecular function	GO:0033218	254	3	18094	49	CACNA1B,RYR2,GRIA3
3.142e-02	-3.46	actin filament-based movement	biological process	GO:0030048	101	2	18204	50	RYR2,CAMK2D
3.147e-02	-3.46	KRT6B (keratin 6B)	protein interactions	3854	108	2	19454	50	PDE4B,CBL
3.149e-02	-3.46	RUFY1 (RUN and FYVE domain containing 1)	protein interactions	80230	466	4	19454	50	PHACTR2,PLD3,NGB,ATP2A1
3.162e-02	-3.45	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	47	GUCY2F,PRKACB,CAMK2D,PRKCA
3.162e-02	-3.45	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	47	PRKCA,CAMK2D,PRKACB,GUCY2F
3.178e-02	-3.45	eye-uveal_tract-malignant_melanoma-mixed	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-mixed	100	2	16828	47	KCND2,PDE4B
3.183e-02	-3.45	active transmembrane transporter activity	molecular function	GO:0022804	444	4	18094	49	SLC18A2,SLC16A14,ATP2A1,SLC39A6
3.189e-02	-3.45	nucleotide biosynthetic process	biological process	GO:0009165	252	3	18204	50	GUCY2F,ADCY8,GUCY1A2
3.191e-02	-3.44	Cell death signalling via NRAGE, NRIF and NADE	REACTOME pathways	R-HSA-204998	76	2	10285	38	KALRN,TIAM2
3.193e-02	-3.44	Globin	interpro domains	IPR000971	12	1	18521	50	NGB
3.193e-02	-3.44	Globin/Proto	interpro domains	IPR012292	12	1	18521	50	NGB
3.193e-02	-3.44	Globin-like_sf	interpro domains	IPR009050	12	1	18521	50	NGB
3.193e-02	-3.44	K_chnl_volt-dep_EAG/ELK/ERG	interpro domains	IPR003938	12	1	18521	50	KCNH6
3.200e-02	-3.44	TMEM109 (transmembrane protein 109)	protein interactions	79073	109	2	19454	50	SLC18A2,ATP2A1
3.203e-02	-3.44	phosphate ion binding	molecular function	GO:0042301	12	1	18094	49	PDE2A
3.203e-02	-3.44	inositol 1,4,5 trisphosphate binding	molecular function	GO:0070679	12	1	18094	49	ITPR1
3.203e-02	-3.44	nuclear glucocorticoid receptor binding	molecular function	GO:0035259	12	1	18094	49	NR4A2
3.203e-02	-3.44	dynactin binding	molecular function	GO:0034452	12	1	18094	49	GSK3B
3.203e-02	-3.44	calcium channel inhibitor activity	molecular function	GO:0019855	12	1	18094	49	ITPR1
3.203e-02	-3.44	cAMP-dependent protein kinase regulator activity	molecular function	GO:0008603	12	1	18094	49	PRKAR2A
3.203e-02	-3.44	monoamine transmembrane transporter activity	molecular function	GO:0008504	12	1	18094	49	SLC18A2
3.204e-02	-3.44	human chr6q24.2	chromosome location	human chr6q24.2	17	1	26134	50	PHACTR2
3.204e-02	-3.44	BEACH	prosite domains	PS50197	9	1	12186	44	NBEA
3.241e-02	-3.43	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	28	PRKCA,GSK3B
3.248e-02	-3.43	maintenance of organelle location	biological process	GO:0051657	12	1	18204	50	ATP2A1
3.248e-02	-3.43	cellular response to glucagon stimulus	biological process	GO:0071377	12	1	18204	50	ADCY8
3.248e-02	-3.43	regulation of cell communication by electrical coupling involved in cardiac conduction	biological process	GO:1901844	12	1	18204	50	CAMK2D
3.248e-02	-3.43	regulation of ventricular cardiac muscle cell action potential	biological process	GO:0098911	12	1	18204	50	RYR2
3.248e-02	-3.43	N-acetylneuraminate metabolic process	biological process	GO:0006054	12	1	18204	50	NPL
3.248e-02	-3.43	response to interleukin-15	biological process	GO:0070672	12	1	18204	50	PLCB1
3.248e-02	-3.43	homocysteine metabolic process	biological process	GO:0050667	12	1	18204	50	DPEP1
3.248e-02	-3.43	response to macrophage colony-stimulating factor	biological process	GO:0036005	12	1	18204	50	PDE2A
3.248e-02	-3.43	epithelial fluid transport	biological process	GO:0042045	12	1	18204	50	ITPR1
3.248e-02	-3.43	nuclear membrane disassembly	biological process	GO:0051081	12	1	18204	50	PRKCA
3.248e-02	-3.43	regulation of glial cell apoptotic process	biological process	GO:0034350	12	1	18204	50	PRKCA
3.248e-02	-3.43	response to interleukin-12	biological process	GO:0070671	12	1	18204	50	PLCB1
3.248e-02	-3.43	regulation of protein localization to centrosome	biological process	GO:1904779	12	1	18204	50	GSK3B
3.248e-02	-3.43	serotonin transport	biological process	GO:0006837	12	1	18204	50	SLC18A2
3.253e-02	-3.43	nucleoside phosphate biosynthetic process	biological process	GO:1901293	254	3	18204	50	GUCY1A2,ADCY8,GUCY2F
3.254e-02	-3.43	breast-carcinoma	COSMIC cancer mutations	breast-carcinoma	15030	46	16828	47	NBEA,NPL,ITPR1,GARNL3,RASD1,NR4A2,RYR2,PRKAR2A,CELF3,PLCE1,TIAM2,PDE4B,KCND2,MRAS,GUCY1A2,KALRN,DPEP1,FOXD3,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,PDE2A,PDE9A,ADCY8,CACNA1B,GRIA3,SLC16A14,SYT10,RXRA,CACNB4,RAB37,PLCB1,PDE1A,KCNH6,NGB,PLD3,ATP2A1,LRCH1,CBL,SMPDL3B,PRKCA,PHACTR2,SLC18A2,SHOC2
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	SHOC2,MRAS
3.254e-02	-3.43	NOTCH3 (notch receptor 3)	protein interactions	4854	110	2	19454	50	GSK3B,CBL
3.256e-02	-3.42	Globin	pfam domains	PF00042	12	1	17795	49	NGB
3.257e-02	-3.42	cellular response to leukemia inhibitory factor	biological process	GO:1990830	103	2	18204	50	CACNB4,MRAS
3.257e-02	-3.42	regulation of neural precursor cell proliferation	biological process	GO:2000177	103	2	18204	50	SHOC2,PDE9A
3.263e-02	-3.42	peptide binding	molecular function	GO:0042277	258	3	18094	49	CACNA1B,RXRA,GRIA3
3.278e-02	-3.42	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	REACTOME pathways	R-HSA-8849469	9	1	10285	38	CBL
3.278e-02	-3.42	EGFR Transactivation by Gastrin	REACTOME pathways	R-HSA-2179392	9	1	10285	38	PRKCA
3.287e-02	-3.42	phosphatase regulator activity	molecular function	GO:0019208	105	2	18094	49	SHOC2,PHACTR2
3.291e-02	-3.41	ANO8 (anoctamin 8)	protein interactions	57719	13	1	19454	50	ATP2A1
3.291e-02	-3.41	NEURL1 (neuralized E3 ubiquitin protein ligase 1)	protein interactions	9148	13	1	19454	50	PDE9A
3.291e-02	-3.41	ZFPM1 (zinc finger protein, FOG family member 1)	protein interactions	161882	13	1	19454	50	GSK3B
3.291e-02	-3.41	PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)	protein interactions	151742	13	1	19454	50	PDE2A
3.291e-02	-3.41	PRKG2 (protein kinase cGMP-dependent 2)	protein interactions	5593	13	1	19454	50	PDE9A
3.291e-02	-3.41	KCNQ2 (potassium voltage-gated channel subfamily Q member 2)	protein interactions	3785	13	1	19454	50	PRKCA
3.291e-02	-3.41	THUMPD2 (THUMP domain containing 2)	protein interactions	80745	13	1	19454	50	SHOC2
3.291e-02	-3.41	TRPV1 (transient receptor potential cation channel subfamily V member 1)	protein interactions	7442	13	1	19454	50	CBL
3.291e-02	-3.41	IL23R (interleukin 23 receptor)	protein interactions	149233	13	1	19454	50	PRKCA
3.291e-02	-3.41	Fam83d (family with sequence similarity 83, member D)	protein interactions	71878	13	1	19454	50	PRKAR2A
3.291e-02	-3.41	CEACAM16 (CEA cell adhesion molecule 16, tectorial membrane component)	protein interactions	388551	13	1	19454	50	CBL
3.291e-02	-3.41	Nfya (nuclear transcription factor-Y alpha)	protein interactions	18044	13	1	19454	50	LRCH1
3.291e-02	-3.41	GUCY2D (guanylate cyclase 2D, retinal)	protein interactions	3000	13	1	19454	50	GUCY2F
3.291e-02	-3.41	CUBN (cubilin)	protein interactions	8029	13	1	19454	50	CBL
3.291e-02	-3.41	KLF2 (KLF transcription factor 2)	protein interactions	10365	13	1	19454	50	GSK3B
3.291e-02	-3.41	PKIA (cAMP-dependent protein kinase inhibitor alpha)	protein interactions	5569	13	1	19454	50	PRKACB
3.291e-02	-3.41	PPP1R2B (PPP1R2 family member B)	protein interactions	153743	13	1	19454	50	GSK3B
3.291e-02	-3.41	CABP1 (calcium binding protein 1)	protein interactions	9478	13	1	19454	50	ITPR1
3.294e-02	-3.41	Regulation of Androgen receptor activity	Pathway Interaction DB	ar_tf_pathway	50	2	2226	13	PDE9A,GSK3B
3.297e-02	-3.41	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	39	16828	47	RYR2,PRKAR2A,CELF3,PLCE1,PDE4B,TIAM2,NBEA,RASD1,ITPR1,GARNL3,FOXD3,RASGRF1,GUCY2F,CAMK2D,SLC39A6,GUCY1A2,KALRN,KCND2,MRAS,CACNB4,PLCB1,SYT10,SLC16A14,RXRA,PDE1A,KCNH6,PDE2A,PDE9A,ADCY8,GRIA3,CACNA1B,PHACTR2,PRKCA,SLC18A2,SHOC2,ATP2A1,CBL,SMPDL3B,LRCH1
3.302e-02	-3.41	SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone)	protein interactions	10910	273	3	19454	50	MINK1,SHOC2,LRCH1
3.309e-02	-3.41	DLG3 (discs large MAGUK scaffold protein 3)	protein interactions	1741	111	2	19454	50	NBEA,GUCY1A2
3.309e-02	-3.41	TMEM120B (transmembrane protein 120B)	protein interactions	144404	111	2	19454	50	ATP2A1,DPEP1
3.315e-02	-3.41	inorganic cation import across plasma membrane	biological process	GO:0098659	104	2	18204	50	CACNA1B,SLC39A6
3.315e-02	-3.41	inorganic ion import across plasma membrane	biological process	GO:0099587	104	2	18204	50	CACNA1B,SLC39A6
3.323e-02	-3.40	cervix	COSMIC cancer mutations	cervix	11793	39	16828	47	RXRA,SYT10,SLC16A14,PLCB1,CACNB4,KCNH6,PDE1A,ADCY8,PDE2A,PDE9A,CACNA1B,GRIA3,PRKCA,PHACTR2,SLC18A2,SHOC2,ATP2A1,LRCH1,SMPDL3B,CBL,PLCE1,CELF3,PRKAR2A,RYR2,TIAM2,PDE4B,NBEA,ITPR1,GARNL3,RASD1,FOXD3,CAMK2D,SLC39A6,GUCY2F,RASGRF1,MRAS,KCND2,KALRN,GUCY1A2
3.333e-02	-3.40	ACTBL2 (actin beta like 2)	protein interactions	345651	274	3	19454	50	PHACTR2,NGB,CBL
3.349e-02	-3.40	G alpha (q) signalling events	REACTOME pathways	R-HSA-416476	192	3	10285	38	ITPR1,KALRN,PLCB1
3.350e-02	-3.40	Wnt signalosome	cellular component	GO:1990909	13	1	19108	50	GSK3B
3.350e-02	-3.40	postsynaptic cytosol	cellular component	GO:0099524	13	1	19108	50	PLCB1
3.351e-02	-3.40	regulation of hormone secretion	biological process	GO:0046883	257	3	18204	50	PLCB1,ITPR1,ADCY8
3.363e-02	-3.39	ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)	protein interactions	3709	112	2	19454	50	CAMK2D,ATP2A1
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	PRKAR2A,PRKACB
3.373e-02	-3.39	response to interleukin-1	biological process	GO:0070555	105	2	18204	50	PLCB1,PRKCA
3.373e-02	-3.39	canonical Wnt signaling pathway	biological process	GO:0060070	105	2	18204	50	NR4A2,GSK3B
3.373e-02	-3.39	response to leukemia inhibitory factor	biological process	GO:1990823	105	2	18204	50	MRAS,CACNB4
3.375e-02	-3.39	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	47	PRKCA,GUCY2F,PRKACB,CAMK2D
3.378e-02	-3.39	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	5	16828	47	PLCE1,PRKCA,GUCY2F,CAMK2D,PRKACB
3.388e-02	-3.38	PICK1 (protein interacting with PRKCA 1)	protein interactions	9463	477	4	19454	50	PRKACB,GRIA3,PRKCA,DPEP1
3.389e-02	-3.38	human chr2q23.3	chromosome location	human chr2q23.3	18	1	26134	50	CACNB4
3.402e-02	-3.38	beta-catenin binding	molecular function	GO:0008013	107	2	18094	49	GSK3B,NR4A2
3.416e-02	-3.38	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	8	16828	47	PDE2A,CACNA1B,NR4A2,SYT10,RYR2,SLC18A2,SLC39A6,TIAM2
3.417e-02	-3.38	Role of Calcineurin-dependent NFAT signaling in lymphocytes	Pathway Interaction DB	nfat_3pathway	51	2	2226	13	GSK3B,PRKCA
3.418e-02	-3.38	LMF2 (lipase maturation factor 2)	protein interactions	91289	113	2	19454	50	ATP2A1,GRIA3
3.418e-02	-3.38	MYL12B (myosin light chain 12B)	protein interactions	103910	113	2	19454	50	CBL,FOXD3
3.432e-02	-3.37	cellular response to carbohydrate stimulus	biological process	GO:0071322	106	2	18204	50	ADCY8,PLCB1
3.432e-02	-3.37	response to retinoic acid	biological process	GO:0032526	106	2	18204	50	GSK3B,RXRA
3.444e-02	-3.37	apical part of cell	cellular component	GO:0045177	471	4	19108	50	SLC39A6,DPEP1,AJM1,ADCY8
3.450e-02	-3.37	Signaling by Wnt	REACTOME pathways	R-HSA-195721	336	4	10285	38	ITPR1,GSK3B,PLCB1,PRKCA
3.460e-02	-3.36	phosphatidylinositol bisphosphate binding	molecular function	GO:1902936	108	2	18094	49	PLCB1,SYT10
3.465e-02	-3.36	titin binding	molecular function	GO:0031432	13	1	18094	49	CAMK2D
3.465e-02	-3.36	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	49	SLC39A6
3.465e-02	-3.36	oxidoreductase activity, acting on other nitrogenous compounds as donors	molecular function	GO:0016661	13	1	18094	49	NGB
3.474e-02	-3.36	ITPRID2 (ITPR interacting domain containing 2)	protein interactions	6744	114	2	19454	50	CBL,CAMK2D
3.474e-02	-3.36	ERCC8 (ERCC excision repair 8, CSA ubiquitin ligase complex subunit)	protein interactions	1161	114	2	19454	50	CAMK2D,PRKCA
3.474e-02	-3.36	HS2ST1 (heparan sulfate 2-O-sulfotransferase 1)	protein interactions	9653	114	2	19454	50	PDE2A,ATP2A1
3.475e-02	-3.36	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	5	16828	47	PLCB1,RYR2,KCND2,GRIA3,CAMK2D
3.478e-02	-3.36	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	9	16828	47	PRKCA,SYT10,TIAM2,RASGRF1,KCND2,PDE2A,ADCY8,NPL,LRCH1
3.478e-02	-3.36	MAP1B (microtubule associated protein 1B)	protein interactions	4131	481	4	19454	50	MINK1,GSK3B,ATP2A1,CACNA1B
3.482e-02	-3.36	negative regulation of signal transduction	biological process	GO:0009968	1393	8	18204	50	PRKACB,GSK3B,CBL,NR4A2,PDE2A,PDE4B,ITPR1,SMPDL3B
3.492e-02	-3.35	neuron apoptotic process	biological process	GO:0051402	107	2	18204	50	NR4A2,RAPSN
3.495e-02	-3.35	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	5	16828	47	GRIA3,CAMK2D,RYR2,PLCB1,KCND2
3.500e-02	-3.35	PH_domain	interpro domains	IPR001849	266	3	18521	50	RASGRF1,KALRN,TIAM2
3.508e-02	-3.35	regulation of catalytic activity	biological process	GO:0050790	1395	8	18204	50	TIAM2,PRKAR2A,ADCY8,DPEP1,GSK3B,RASGRF1,LRCH1,CBL
3.514e-02	-3.35	locomotor rhythm	biological process	GO:0045475	13	1	18204	50	KCND2
3.514e-02	-3.35	negative regulation of epidermal growth factor-activated receptor activity	biological process	GO:0007175	13	1	18204	50	CBL
3.514e-02	-3.35	response to morphine	biological process	GO:0043278	13	1	18204	50	ADCY8
3.514e-02	-3.35	positive regulation of calcium ion-dependent exocytosis	biological process	GO:0045956	13	1	18204	50	SYT10
3.514e-02	-3.35	midbrain dopaminergic neuron differentiation	biological process	GO:1904948	13	1	18204	50	NR4A2
3.514e-02	-3.35	calcium ion transport into cytosol	biological process	GO:0060402	13	1	18204	50	RYR2
3.514e-02	-3.35	membrane disassembly	biological process	GO:0030397	13	1	18204	50	PRKCA
3.514e-02	-3.35	regulation of cAMP-dependent protein kinase activity	biological process	GO:2000479	13	1	18204	50	PRKAR2A
3.514e-02	-3.35	detection of calcium ion	biological process	GO:0005513	13	1	18204	50	RYR2
3.518e-02	-3.35	immune response-regulating cell surface receptor signaling pathway	biological process	GO:0002768	262	3	18204	50	PDE4B,SLC39A6,CACNB4
3.518e-02	-3.35	nucleobase-containing compound biosynthetic process	biological process	GO:0034654	896	6	18204	50	GUCY1A2,ADCY8,GUCY2F,RXRA,CELF3,NR4A2
3.522e-02	-3.35	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	47	KCNH6,SYT10,ATP2A1
3.530e-02	-3.34	GNS (glucosamine (N-acetyl)-6-sulfatase)	protein interactions	2799	115	2	19454	50	PRKCA,PRKAR2A
3.535e-02	-3.34	bone-chondrosarcoma	COSMIC cancer mutations	bone-chondrosarcoma	106	2	16828	47	RYR2,PDE4B
3.540e-02	-3.34	TMEM44 (transmembrane protein 44)	protein interactions	93109	14	1	19454	50	GSK3B
3.540e-02	-3.34	PLXNA4 (plexin A4)	protein interactions	91584	14	1	19454	50	NGB
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	CAMK2D
3.540e-02	-3.34	RNF121 (ring finger protein 121)	protein interactions	55298	14	1	19454	50	PDE2A
3.540e-02	-3.34	PGS1 (phosphatidylglycerophosphate synthase 1)	protein interactions	9489	14	1	19454	50	PLD3
3.540e-02	-3.34	KCNIP2 (potassium voltage-gated channel interacting protein 2)	protein interactions	30819	14	1	19454	50	KCND2
3.540e-02	-3.34	TAS2R7 (taste 2 receptor member 7)	protein interactions	50837	14	1	19454	50	PRKCA
3.540e-02	-3.34	PRSS37 (serine protease 37)	protein interactions	136242	14	1	19454	50	GSK3B
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	PRKCA
3.540e-02	-3.34	PLCL2 (phospholipase C like 2)	protein interactions	23228	14	1	19454	50	SHOC2
3.540e-02	-3.34	FBN3 (fibrillin 3)	protein interactions	84467	14	1	19454	50	GSK3B
3.542e-02	-3.34	Signaling events mediated by Stem cell factor receptor (c-Kit)	Pathway Interaction DB	kitpathway	52	2	2226	13	GSK3B,CBL
3.569e-02	-3.33	DYNLL1 (dynein light chain LC8-type 1)	protein interactions	8655	485	4	19454	50	MINK1,GSK3B,PRKACB,PRKAR2A
3.572e-02	-3.33	autonomic_ganglia-adrenal_gland-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-adrenal_gland-paraganglioma-benign	13	1	16828	47	PDE2A
3.574e-02	-3.33	human chr2q32.1	chromosome location	human chr2q32.1	19	1	26134	50	PDE1A
3.586e-02	-3.33	RDH11 (retinol dehydrogenase 11)	protein interactions	51109	116	2	19454	50	DPEP1,PRKCA
3.590e-02	-3.33	Rap/Ran-GAP	gene3d domains	3.40.50.11210	11	1	14470	48	GARNL3
3.592e-02	-3.33	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	3	18094	49	GRIA3,SLC39A6,SLC16A14
3.595e-02	-3.33	endometrium-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-endometrioid_carcinoma	15680	47	16828	47	MRAS,KCND2,KALRN,DPEP1,GUCY1A2,PRKACB,SLC39A6,CAMK2D,GUCY2F,RASGRF1,FOXD3,RAPSN,ITPR1,GARNL3,RASD1,NPL,NBEA,TIAM2,PDE4B,NR4A2,CELF3,PLCE1,PRKAR2A,RYR2,LRCH1,SMPDL3B,CBL,PLD3,NGB,ATP2A1,SHOC2,SLC18A2,PRKCA,PHACTR2,CACNA1B,GRIA3,PDE2A,ADCY8,PDE9A,KCNH6,PDE1A,SYT10,RXRA,SLC16A14,RAB37,PLCB1,CACNB4
3.598e-02	-3.32	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	8	16828	47	SYT10,NR4A2,RYR2,TIAM2,SLC39A6,SLC18A2,PDE2A,CACNA1B
3.603e-02	-3.32	dopaminergic synapse	cellular component	GO:0098691	14	1	19108	50	SLC18A2
3.605e-02	-3.32	Ion Channel and Phorbal Esters Signaling Pathway	SMPDB pathways	SMP0090032	5	1	1369	10	PRKCA
3.605e-02	-3.32	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	10	PRKACB
3.620e-02	-3.32	regulation of protein secretion	biological process	GO:0050708	265	3	18204	50	ITPR1,ADCY8,PLCB1
3.635e-02	-3.31	Zinc influx into cells by the SLC39 gene family	REACTOME pathways	R-HSA-442380	10	1	10285	38	SLC39A6
3.635e-02	-3.31	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	38	ADCY8
3.642e-02	-3.31	HSP90AB4P (heat shock protein 90 alpha family class B member 4, pseudogene)	protein interactions	664618	117	2	19454	50	PLD3,PRKACB
3.642e-02	-3.31	ARL14 (ADP ribosylation factor like GTPase 14)	protein interactions	80117	117	2	19454	50	MINK1,NBEA
3.668e-02	-3.31	CAV1 (caveolin 1)	protein interactions	857	719	5	19454	50	SLC39A6,PDE2A,MINK1,GSK3B,PLD3
3.680e-02	-3.30	PPARG (peroxisome proliferator activated receptor gamma)	protein interactions	5468	285	3	19454	50	NR4A2,RXRA,PRKCA
3.682e-02	-3.30	postsynaptic membrane	cellular component	GO:0045211	280	3	19108	50	RAPSN,GRIA3,KCND2
3.704e-02	-3.30	endometrioid_carcinoma	COSMIC cancer mutations	endometrioid_carcinoma	15690	47	16828	47	PDE1A,KCNH6,SYT10,SLC16A14,RXRA,CACNB4,RAB37,PLCB1,CACNA1B,GRIA3,ADCY8,PDE2A,PDE9A,SLC18A2,SHOC2,PRKCA,PHACTR2,LRCH1,CBL,SMPDL3B,NGB,PLD3,ATP2A1,TIAM2,PDE4B,NR4A2,RYR2,PRKAR2A,PLCE1,CELF3,ITPR1,GARNL3,RASD1,NPL,NBEA,SLC39A6,CAMK2D,PRKACB,RASGRF1,GUCY2F,FOXD3,RAPSN,KCND2,MRAS,KALRN,DPEP1,GUCY1A2
3.715e-02	-3.29	regulation of multicellular organismal process	biological process	GO:0051239	3113	14	18204	50	KCND2,KCNH6,CAMK2D,PLCB1,NR4A2,RXRA,ATP2A1,GSK3B,PRKCA,PDE4B,RYR2,PDE9A,TIAM2,PLD3
3.715e-02	-3.29	ZIP	interpro domains	IPR003689	14	1	18521	50	SLC39A6
3.715e-02	-3.29	Ras_G-nucl-exch_fac_CS	interpro domains	IPR019804	14	1	18521	50	RASGRF1
3.727e-02	-3.29	oxygen carrier activity	molecular function	GO:0005344	14	1	18094	49	NGB
3.727e-02	-3.29	endometrium	COSMIC cancer mutations	endometrium	15692	47	16828	47	NGB,PLD3,ATP2A1,LRCH1,CBL,SMPDL3B,PRKCA,PHACTR2,SHOC2,SLC18A2,ADCY8,PDE9A,PDE2A,CACNA1B,GRIA3,RXRA,SYT10,SLC16A14,CACNB4,PLCB1,RAB37,PDE1A,KCNH6,KCND2,MRAS,DPEP1,GUCY1A2,KALRN,FOXD3,RAPSN,CAMK2D,SLC39A6,PRKACB,RASGRF1,GUCY2F,NBEA,NPL,RASD1,GARNL3,ITPR1,NR4A2,PRKAR2A,RYR2,PLCE1,CELF3,TIAM2,PDE4B
3.745e-02	-3.28	endoplasmic reticulum	cellular component	GO:0005783	2051	10	19108	50	RASD1,SLC39A6,RYR2,PLD3,ITPR1,CAMK2D,PRKCA,ATP2A1,PDE9A,PDE2A
3.746e-02	-3.28	Inositol phosphate metabolism	KEGG pathways	hsa00562	71	2	7161	31	PLCB1,PLCE1
3.746e-02	-3.28	Inositol phosphate metabolism	KEGG pathways	ko00562	71	2	7161	31	PLCB1,PLCE1
3.755e-02	-3.28	NONO (non-POU domain containing octamer binding)	protein interactions	4841	493	4	19454	50	GSK3B,PRKACB,PDE4B,RXRA
3.755e-02	-3.28	SEC62 (SEC62 homolog, preprotein translocation factor)	protein interactions	7095	493	4	19454	50	SLC39A6,PDE2A,ITPR1,PLD3
3.759e-02	-3.28	human chr18q12.2	chromosome location	human chr18q12.2	20	1	26134	50	SLC39A6
3.762e-02	-3.28	GTPase activator activity	molecular function	GO:0005096	273	3	18094	49	PLCB1,GARNL3,TIAM2
3.779e-02	-3.28	cellular response to forskolin	biological process	GO:1904322	14	1	18204	50	ADCY8
3.779e-02	-3.28	response to redox state	biological process	GO:0051775	14	1	18204	50	RYR2
3.779e-02	-3.28	regulation of long-term synaptic depression	biological process	GO:1900452	14	1	18204	50	ADCY8
3.779e-02	-3.28	protein localization to postsynaptic specialization membrane	biological process	GO:0099633	14	1	18204	50	RAPSN
3.779e-02	-3.28	positive regulation of striated muscle contraction	biological process	GO:0045989	14	1	18204	50	ATP2A1
3.779e-02	-3.28	response to forskolin	biological process	GO:1904321	14	1	18204	50	ADCY8
3.779e-02	-3.28	nerve growth factor signaling pathway	biological process	GO:0038180	14	1	18204	50	SHOC2
3.779e-02	-3.28	neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0099645	14	1	18204	50	RAPSN
3.779e-02	-3.28	response to isoquinoline alkaloid	biological process	GO:0014072	14	1	18204	50	ADCY8
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	CAMK2D
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	CAMK2D
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR2
3.788e-02	-3.27	CBLIF (cobalamin binding intrinsic factor)	protein interactions	2694	15	1	19454	50	CBL
3.788e-02	-3.27	B4GALNT3 (beta-1,4-N-acetyl-galactosaminyltransferase 3)	protein interactions	283358	15	1	19454	50	ATP2A1
3.788e-02	-3.27	CCDC127 (coiled-coil domain containing 127)	protein interactions	133957	15	1	19454	50	PDE2A
3.788e-02	-3.27	FGL2 (fibrinogen like 2)	protein interactions	10875	15	1	19454	50	ITPR1
3.788e-02	-3.27	TESPA1 (thymocyte expressed, positive selection associated 1)	protein interactions	9840	15	1	19454	50	ITPR1
3.788e-02	-3.27	OGG1 (8-oxoguanine DNA glycosylase)	protein interactions	4968	15	1	19454	50	PRKCA
3.788e-02	-3.27	MUC16 (mucin 16, cell surface associated)	protein interactions	94025	15	1	19454	50	NGB
3.788e-02	-3.27	CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)	protein interactions	652968	15	1	19454	50	RXRA
3.788e-02	-3.27	FN3K (fructosamine 3 kinase)	protein interactions	64122	15	1	19454	50	PRKCA
3.788e-02	-3.27	ADRA1B (adrenoceptor alpha 1B)	protein interactions	147	15	1	19454	50	PRKCA
3.788e-02	-3.27	GRM7 (glutamate metabotropic receptor 7)	protein interactions	2917	15	1	19454	50	PRKCA
3.788e-02	-3.27	PARP3 (poly(ADP-ribose) polymerase family member 3)	protein interactions	10039	15	1	19454	50	GSK3B
3.788e-02	-3.27	ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive))	protein interactions	957	15	1	19454	50	PRKCA
3.788e-02	-3.27	KLHL5 (kelch like family member 5)	protein interactions	51088	15	1	19454	50	CBL
3.788e-02	-3.27	TMEM181 (transmembrane protein 181)	protein interactions	57583	15	1	19454	50	DPEP1
3.788e-02	-3.27	FZD1 (frizzled class receptor 1)	protein interactions	8321	15	1	19454	50	GSK3B
3.788e-02	-3.27	Zip	pfam domains	PF02535	14	1	17795	49	SLC39A6
3.797e-02	-3.27	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	3	18094	49	SLC18A2,SLC39A6,ATP2A1
3.799e-02	-3.27	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	47	GUCY2F,CAMK2D,PRKACB,PRKCA
3.802e-02	-3.27	OCLN (occludin)	protein interactions	100506658	495	4	19454	50	PRKCA,NBEA,MINK1,SLC39A6
3.814e-02	-3.27	PLS1 (plastin 1)	protein interactions	5357	120	2	19454	50	GUCY2F,CBL
3.814e-02	-3.27	LPCAT1 (lysophosphatidylcholine acyltransferase 1)	protein interactions	79888	120	2	19454	50	ATP2A1,GSK3B
3.814e-02	-3.27	IBTK (inhibitor of Bruton tyrosine kinase)	protein interactions	25998	120	2	19454	50	GSK3B,PRKCA
3.814e-02	-3.27	RUNX1T1 (RUNX1 partner transcriptional co-repressor 1)	protein interactions	862	120	2	19454	50	PRKAR2A,GSK3B
3.814e-02	-3.27	MED24 (mediator complex subunit 24)	protein interactions	9862	120	2	19454	50	RXRA,GSK3B
3.843e-02	-3.26	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	hsa05412	72	2	7161	31	CACNB4,RYR2
3.843e-02	-3.26	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	ko05412	72	2	7161	31	RYR2,CACNB4
3.851e-02	-3.26	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	47	GUCY2F,PRKACB,CAMK2D,PRKCA
3.852e-02	-3.26	Axon guidance	KEGG pathways	hsa04360	174	3	7161	31	CAMK2D,PRKCA,GSK3B
3.852e-02	-3.26	Axon guidance	KEGG pathways	ko04360	174	3	7161	31	PRKCA,GSK3B,CAMK2D
3.856e-02	-3.26	positive regulation of plasma membrane bounded cell projection assembly	biological process	GO:0120034	113	2	18204	50	GSK3B,PLCE1
3.856e-02	-3.26	heart process	biological process	GO:0003015	113	2	18204	50	CAMK2D,RYR2
3.856e-02	-3.26	regulation of regulated secretory pathway	biological process	GO:1903305	113	2	18204	50	CACNB4,SYT10
3.874e-02	-3.25	DDX5 (DEAD-box helicase 5)	protein interactions	1655	498	4	19454	50	PRKACB,GSK3B,CBL,PRKCA
3.887e-02	-3.25	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	9	18204	50	PLCB1,CAMK2D,ATP2A1,RXRA,PRKCA,RYR2,PDE4B,PDE9A,TIAM2
3.898e-02	-3.24	CBL (Cbl proto-oncogene)	protein interactions	867	499	4	19454	50	PRKAR2A,PRKACB,CBL,PRKCA
3.900e-02	-3.24	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	WikiPathways	WP2380	144	3	5310	28	RASGRF1,GRIA3,GSK3B
3.902e-02	-3.24	RAPGAP	prosite domains	PS50085	11	1	12186	44	GARNL3
3.910e-02	-3.24	NFKB1 (nuclear factor kappa B subunit 1)	protein interactions	4790	292	3	19454	50	GSK3B,PLD3,RXRA
3.910e-02	-3.24	Globins	gene3d domains	1.10.490.10	12	1	14470	48	NGB
3.910e-02	-3.24	-	gene3d domains	3.10.450.50	12	1	14470	48	CAMK2D
3.915e-02	-3.24	Beach	smart domains	SM01026	9	1	9717	43	NBEA
3.922e-02	-3.24	PHB2 (prohibitin 2)	protein interactions	11331	500	4	19454	50	PDE2A,CBL,PRKCA,PLCB1
3.932e-02	-3.24	Kit receptor signaling pathway	WikiPathways	WP304	60	2	5310	28	PRKCA,CBL
3.943e-02	-3.23	PDIA6 (protein disulfide isomerase family A member 6)	protein interactions	10130	293	3	19454	50	PDE4B,PLD3,NGB
3.956e-02	-3.23	import into cell	biological process	GO:0098657	687	5	18204	50	CBL,CACNA1B,SLC39A6,SHOC2,SLC18A2
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP2A1
3.975e-02	-3.23	NTF2-like_dom_sf	interpro domains	IPR032710	15	1	18521	50	CAMK2D
3.977e-02	-3.22	KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)	protein interactions	10008	294	3	19454	50	MINK1,PRKACB,PLCB1
3.988e-02	-3.22	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	molecular function	GO:0016812	15	1	18094	49	DPEP1
3.988e-02	-3.22	nuclear vitamin D receptor binding	molecular function	GO:0042809	15	1	18094	49	RXRA
3.988e-02	-3.22	BAD (BCL2 associated agonist of cell death)	protein interactions	572	123	2	19454	50	PRKCA,PRKACB
3.988e-02	-3.22	GNAQ (G protein subunit alpha q)	protein interactions	2776	123	2	19454	50	SLC16A14,PLCB1
3.992e-02	-3.22	Import of palmitoyl-CoA into the mitochondrial matrix	REACTOME pathways	R-HSA-200425	11	1	10285	38	RXRA
3.992e-02	-3.22	Interleukin-6 signaling	REACTOME pathways	R-HSA-1059683	11	1	10285	38	CBL
4.000e-02	-3.22	Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME pathways	R-HSA-2029480	86	2	10285	38	PLD3,ITPR1
4.002e-02	-3.22	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	2	18094	49	SLC39A6,SLC18A2
4.008e-02	-3.22	learning or memory	biological process	GO:0007611	276	3	18204	50	PLCB1,ADCY8,RASGRF1
4.009e-02	-3.22	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	47	GUCY2F,CAMK2D,PRKACB,PRKCA
4.035e-02	-3.21	RD3 (RD3 regulator of GUCY2D)	protein interactions	343035	16	1	19454	50	NBEA
4.035e-02	-3.21	DUS1L (dihydrouridine synthase 1 like)	protein interactions	64118	16	1	19454	50	FOXD3
4.035e-02	-3.21	ESPN (espin)	protein interactions	83715	16	1	19454	50	RAB37
4.035e-02	-3.21	RHO (rhodopsin)	protein interactions	6010	16	1	19454	50	PRKCA
4.035e-02	-3.21	WWC3 (WWC family member 3)	protein interactions	55841	16	1	19454	50	PRKCA
4.035e-02	-3.21	CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2)	protein interactions	729438	16	1	19454	50	RXRA
4.035e-02	-3.21	SLC6A9 (solute carrier family 6 member 9)	protein interactions	6536	16	1	19454	50	PRKCA
4.035e-02	-3.21	GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3)	protein interactions	2562	16	1	19454	50	PRKCA
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	MINK1
4.035e-02	-3.21	SIGIRR (single Ig and TIR domain containing)	protein interactions	59307	16	1	19454	50	GSK3B
4.035e-02	-3.21	SULT1E1 (sulfotransferase family 1E member 1)	protein interactions	6783	16	1	19454	50	PDE9A
4.035e-02	-3.21	NRGN (neurogranin)	protein interactions	4900	16	1	19454	50	PRKCA
4.035e-02	-3.21	CMTM2 (CKLF like MARVEL transmembrane domain containing 2)	protein interactions	146225	16	1	19454	50	GSK3B
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKCA
4.035e-02	-3.21	ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)	protein interactions	9583	16	1	19454	50	ATP2A1
4.035e-02	-3.21	NFE2L3 (NFE2 like bZIP transcription factor 3)	protein interactions	9603	16	1	19454	50	GSK3B
4.035e-02	-3.21	C2orf88 (chromosome 2 open reading frame 88)	protein interactions	84281	16	1	19454	50	PRKACB
4.039e-02	-3.21	Cardiac muscle contraction	KEGG pathways	hsa04260	74	2	7161	31	CACNB4,RYR2
4.039e-02	-3.21	Cardiac muscle contraction	KEGG pathways	ko04260	74	2	7161	31	RYR2,CACNB4
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR2
4.043e-02	-3.21	establishment of protein localization to postsynaptic membrane	biological process	GO:1903540	15	1	18204	50	RAPSN
4.043e-02	-3.21	negative regulation of calcineurin-NFAT signaling cascade	biological process	GO:0070885	15	1	18204	50	GSK3B
4.043e-02	-3.21	motor neuron apoptotic process	biological process	GO:0097049	15	1	18204	50	RAPSN
4.043e-02	-3.21	cellular response to nitric oxide	biological process	GO:0071732	15	1	18204	50	DPEP1
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	CAMK2D
4.043e-02	-3.21	negative regulation of calcineurin-mediated signaling	biological process	GO:0106057	15	1	18204	50	GSK3B
4.043e-02	-3.21	amino sugar catabolic process	biological process	GO:0046348	15	1	18204	50	NPL
4.043e-02	-3.21	oxygen transport	biological process	GO:0015671	15	1	18204	50	NGB
4.043e-02	-3.21	regulation of motor neuron apoptotic process	biological process	GO:2000671	15	1	18204	50	RAPSN
4.043e-02	-3.21	gamma-aminobutyric acid transport	biological process	GO:0015812	15	1	18204	50	CACNB4
4.043e-02	-3.21	regulation of presynaptic cytosolic calcium ion concentration	biological process	GO:0099509	15	1	18204	50	CACNB4
4.043e-02	-3.21	negative regulation of lymphocyte migration	biological process	GO:2000402	15	1	18204	50	LRCH1
4.044e-02	-3.21	regulation of cation channel activity	biological process	GO:2001257	116	2	18204	50	CAMK2D,CACNB4
4.045e-02	-3.21	PTK2 (protein tyrosine kinase 2)	protein interactions	5747	296	3	19454	50	CBL,GSK3B,CAMK2D
4.047e-02	-3.21	TM9SF3 (transmembrane 9 superfamily member 3)	protein interactions	56889	124	2	19454	50	ATP2A1,PLD3
4.047e-02	-3.21	PSME2 (proteasome activator subunit 2)	protein interactions	5721	124	2	19454	50	PLD3,CBL
4.047e-02	-3.21	CEBPA (CCAAT enhancer binding protein alpha)	protein interactions	1050	124	2	19454	50	RASGRF1,GSK3B
4.047e-02	-3.21	ANO6 (anoctamin 6)	protein interactions	196527	124	2	19454	50	PDE2A,ATP2A1
4.053e-02	-3.21	CRAL_TRIO_2	pfam domains	PF13716	15	1	17795	49	KALRN
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP2A1
4.083e-02	-3.20	neuron projection development	biological process	GO:0031175	693	5	18204	50	NR4A2,KALRN,GSK3B,RASGRF1,MINK1
4.086e-02	-3.20	G protein-coupled receptor signaling pathway	biological process	GO:0007186	1178	7	18204	50	PDE2A,PLCB1,ADCY8,ITPR1,PRKACB,PLCE1,RASD1
4.127e-02	-3.19	human chr2q36.3	chromosome location	human chr2q36.3	22	1	26134	50	SLC16A14
4.127e-02	-3.19	human chr10q25.2	chromosome location	human chr10q25.2	22	1	26134	50	SHOC2
4.145e-02	-3.18	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	38	CAMK2D,ATP2A1,RYR2
4.166e-02	-3.18	GBA1 (glucosylceramidase beta 1)	protein interactions	2629	126	2	19454	50	CBL,PDE2A
4.170e-02	-3.18	G alpha (12/13) signalling events	REACTOME pathways	R-HSA-416482	88	2	10285	38	KALRN,TIAM2
4.170e-02	-3.18	positive regulation of calcium ion transport	biological process	GO:0051928	118	2	18204	50	ATP2A1,RYR2
4.174e-02	-3.18	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection	WikiPathways	WP3863	62	2	5310	28	GSK3B,CBL
4.226e-02	-3.16	TELO2 (telomere maintenance 2)	protein interactions	9894	127	2	19454	50	SLC18A2,PLD3
4.235e-02	-3.16	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	50	PRKAR2A
4.248e-02	-3.16	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0099507	16	1	18094	49	GRIA3
4.248e-02	-3.16	lamin binding	molecular function	GO:0005521	16	1	18094	49	PLCB1
4.248e-02	-3.16	diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004697	16	1	18094	49	PRKCA
4.248e-02	-3.16	glutamate-gated receptor activity	molecular function	GO:0004970	16	1	18094	49	GRIA3
4.248e-02	-3.16	sodium:chloride symporter activity	molecular function	GO:0015378	16	1	18094	49	SLC18A2
4.248e-02	-3.16	cGMP binding	molecular function	GO:0030553	16	1	18094	49	PDE2A
4.250e-02	-3.16	CNMP_BINDING_2	prosite domains	PS00889	12	1	12186	44	PRKAR2A
4.250e-02	-3.16	GLOBIN	prosite domains	PS01033	12	1	12186	44	NGB
4.256e-02	-3.16	Cellular response to heat stress	REACTOME pathways	R-HSA-3371556	89	2	10285	38	CAMK2D,GSK3B
4.261e-02	-3.16	MFS	prosite domains	PS50850	91	2	12186	44	SLC18A2,SLC16A14
4.266e-02	-3.15	D-myo-inositol (1,4,5)-trisphosphate biosynthesis	BIOCYC pathways	META_PWY-6351	13	1	902	3	PLCE1
4.282e-02	-3.15	NHEJ1 (non-homologous end joining factor 1)	protein interactions	79840	17	1	19454	50	PRKACB
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	KCND2
4.282e-02	-3.15	FAM163B (family with sequence similarity 163 member B)	protein interactions	642968	17	1	19454	50	CAMK2D
4.282e-02	-3.15	KRT84 (keratin 84)	protein interactions	3890	17	1	19454	50	CBL
4.282e-02	-3.15	CSAD (cysteine sulfinic acid decarboxylase)	protein interactions	51380	17	1	19454	50	GSK3B
4.282e-02	-3.15	ZNF227 (zinc finger protein 227)	protein interactions	7770	17	1	19454	50	GSK3B
4.282e-02	-3.15	MT1G (metallothionein 1G)	protein interactions	4495	17	1	19454	50	NGB
4.282e-02	-3.15	FRAT1 (FRAT regulator of WNT signaling pathway 1)	protein interactions	10023	17	1	19454	50	GSK3B
4.282e-02	-3.15	LIPT1 (lipoyltransferase 1)	protein interactions	51601	17	1	19454	50	PRKCA
4.282e-02	-3.15	CYP3A4 (cytochrome P450 family 3 subfamily A member 4)	protein interactions	1576	17	1	19454	50	PRKCA
4.282e-02	-3.15	CYP20A1 (cytochrome P450 family 20 subfamily A member 1)	protein interactions	57404	17	1	19454	50	PDE2A
4.282e-02	-3.15	Ctnnb1 (catenin beta 1)	protein interactions	12387	17	1	19454	50	GSK3B
4.282e-02	-3.15	TNNT2 (troponin T2, cardiac type)	protein interactions	7139	17	1	19454	50	PRKCA
4.282e-02	-3.15	PDE7A (phosphodiesterase 7A)	protein interactions	5150	17	1	19454	50	PRKCA
4.286e-02	-3.15	TRPM7 (transient receptor potential cation channel subfamily M member 7)	protein interactions	54822	128	2	19454	50	ATP2A1,PLCB1
4.286e-02	-3.15	ELOVL4 (ELOVL fatty acid elongase 4)	protein interactions	6785	128	2	19454	50	SLC18A2,DPEP1
4.286e-02	-3.15	BTK (Bruton tyrosine kinase)	protein interactions	695	128	2	19454	50	PRKCA,CBL
4.296e-02	-3.15	phospholipid binding	molecular function	GO:0005543	489	4	18094	49	PLCB1,DPEP1,ITPR1,SYT10
4.297e-02	-3.15	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	6	19454	50	MINK1,PRKAR2A,SLC39A6,RASGRF1,PRKCA,KALRN
4.299e-02	-3.15	striated muscle contraction	biological process	GO:0006941	120	2	18204	50	CAMK2D,RYR2
4.307e-02	-3.14	regulation of cell communication by electrical coupling	biological process	GO:0010649	16	1	18204	50	CAMK2D
4.307e-02	-3.14	response to ether	biological process	GO:0045472	16	1	18204	50	PLCB1
4.307e-02	-3.14	positive regulation of CREB transcription factor activity	biological process	GO:0032793	16	1	18204	50	ADCY8
4.307e-02	-3.14	cardiac left ventricle morphogenesis	biological process	GO:0003214	16	1	18204	50	RYR2
4.307e-02	-3.14	positive regulation of macrophage differentiation	biological process	GO:0045651	16	1	18204	50	PRKCA
4.307e-02	-3.14	neutrophil homeostasis	biological process	GO:0001780	16	1	18204	50	PDE4B
4.307e-02	-3.14	regulation of cellular response to heat	biological process	GO:1900034	16	1	18204	50	GSK3B
4.311e-02	-3.14	human chr3q22.3	chromosome location	human chr3q22.3	23	1	26134	50	MRAS
4.311e-02	-3.14	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	10	PRKACB
4.311e-02	-3.14	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	10	PRKACB
4.312e-02	-3.14	positive regulation of molecular function	biological process	GO:0044093	1192	7	18204	50	RYR2,ADCY8,RXRA,TIAM2,GSK3B,ATP2A1,RASGRF1
4.313e-02	-3.14	protein homodimerization activity	molecular function	GO:0042803	714	5	18094	49	ADCY8,CAMK2D,ATP2A1,PDE2A,SYT10
4.316e-02	-3.14	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	47	16828	47	MRAS,KCND2,KALRN,GUCY1A2,DPEP1,PRKACB,CAMK2D,SLC39A6,GUCY2F,RASGRF1,FOXD3,RAPSN,GARNL3,ITPR1,RASD1,NPL,NBEA,TIAM2,PDE4B,NR4A2,CELF3,PLCE1,RYR2,PRKAR2A,LRCH1,SMPDL3B,CBL,NGB,PLD3,ATP2A1,SLC18A2,SHOC2,PRKCA,PHACTR2,CACNA1B,GRIA3,PDE2A,ADCY8,PDE9A,KCNH6,PDE1A,SLC16A14,SYT10,RXRA,PLCB1,RAB37,CACNB4
4.317e-02	-3.14	potassium channel activity	molecular function	GO:0005267	122	2	18094	49	KCNH6,KCND2
4.321e-02	-3.14	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	11	16828	47	RXRA,RYR2,TIAM2,PDE1A,KCNH6,GUCY2F,NBEA,CACNA1B,GARNL3,ITPR1,GRIA3
4.321e-02	-3.14	RRP1B (ribosomal RNA processing 1B)	protein interactions	23076	304	3	19454	50	PRKCA,GSK3B,PRKACB
4.335e-02	-3.14	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	49	SLC39A6,SLC16A14,SLC18A2
4.337e-02	-3.14	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	4	16828	47	PRKCA,PLCB1,CACNA1B,RASGRF1
4.343e-02	-3.14	MAPK6/MAPK4 signaling	REACTOME pathways	R-HSA-5687128	90	2	10285	38	PRKACB,KALRN
4.346e-02	-3.14	PLD1 (phospholipase D1)	protein interactions	5337	129	2	19454	50	PLD3,PRKCA
4.358e-02	-3.13	platelet alpha granule membrane	cellular component	GO:0031092	17	1	19108	50	PHACTR2
4.374e-02	-3.13	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	23	16828	47	ITPR1,GARNL3,RASD1,CACNA1B,GRIA3,KCNH6,TIAM2,PDE1A,SYT10,SLC16A14,PLCE1,RAB37,RYR2,LRCH1,CBL,PLD3,KCND2,KALRN,DPEP1,ATP2A1,SLC18A2,GUCY2F,FOXD3
4.392e-02	-3.13	CACHANNEL	prints domains	PR00167	9	1	5227	26	CACNA1B
4.407e-02	-3.12	ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group))	protein interactions	4363	130	2	19454	50	ATP2A1,PDE2A
4.413e-02	-3.12	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	22	16828	47	GUCY1A2,KALRN,ATP2A1,PLD3,KCND2,RASGRF1,PRKACB,SLC18A2,SLC39A6,NBEA,PDE9A,ADCY8,PDE2A,GRIA3,ITPR1,CACNA1B,PLCB1,RYR2,CACNB4,NR4A2,SYT10,PDE1A
4.413e-02	-3.12	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	22	16828	47	GRIA3,ITPR1,CACNA1B,NBEA,PDE2A,PDE9A,ADCY8,PDE1A,PLCB1,RYR2,CACNB4,NR4A2,SYT10,GUCY1A2,KALRN,ATP2A1,PLD3,KCND2,RASGRF1,PRKACB,SLC18A2,SLC39A6
4.421e-02	-3.12	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	6	16828	47	PRKACB,CAMK2D,GUCY2F,PDE4B,GRIA3,PRKCA
4.427e-02	-3.12	ACTA2 (actin alpha 2, smooth muscle)	protein interactions	59	307	3	19454	50	GUCY2F,MINK1,PHACTR2
4.451e-02	-3.11	identical protein binding	molecular function	GO:0042802	2043	10	18094	49	ADCY8,RXRA,PLCB1,NPL,CAMK2D,GUCY2F,PDE2A,RYR2,SYT10,ATP2A1
4.463e-02	-3.11	ATM (ATM serine/threonine kinase)	protein interactions	472	308	3	19454	50	CBL,MINK1,PRKCA
4.468e-02	-3.11	GPR35 (G protein-coupled receptor 35)	protein interactions	2859	131	2	19454	50	SLC39A6,PLD3
4.493e-02	-3.10	Synaptotagmin	interpro domains	IPR001565	17	1	18521	50	SYT10
4.494e-02	-3.10	human chr8q24.22	chromosome location	human chr8q24.22	24	1	26134	50	ADCY8
4.507e-02	-3.10	nuclear retinoid X receptor binding	molecular function	GO:0046965	17	1	18094	49	NR4A2
4.507e-02	-3.10	GDP-dissociation inhibitor activity	molecular function	GO:0005092	17	1	18094	49	NGB
4.507e-02	-3.10	dipeptidase activity	molecular function	GO:0016805	17	1	18094	49	DPEP1
4.513e-02	-3.10	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	23	16828	47	PDE4B,TIAM2,PDE1A,PLCB1,PLCE1,CELF3,PRKAR2A,NR4A2,RXRA,PDE2A,ADCY8,GUCY2F,RASGRF1,PRKACB,SLC18A2,SLC39A6,PHACTR2,SMPDL3B,CBL,DPEP1,KALRN,GUCY1A2,ATP2A1
4.529e-02	-3.09	ATP1B2 (ATPase Na+/K+ transporting subunit beta 2)	protein interactions	482	18	1	19454	50	NGB
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKCA
4.529e-02	-3.09	KCNQ1 (potassium voltage-gated channel subfamily Q member 1)	protein interactions	3784	18	1	19454	50	PRKAR2A
4.529e-02	-3.09	RYR3 (ryanodine receptor 3)	protein interactions	6263	18	1	19454	50	RYR2
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	CBL
4.529e-02	-3.09	Csnk1d (casein kinase 1, delta)	protein interactions	104318	18	1	19454	50	PRKAR2A
4.529e-02	-3.09	CSRP3 (cysteine and glycine rich protein 3)	protein interactions	8048	18	1	19454	50	SMPDL3B
4.529e-02	-3.09	MVB12B (multivesicular body subunit 12B)	protein interactions	89853	18	1	19454	50	PDE2A
4.529e-02	-3.09	TLCD1 (TLC domain containing 1)	protein interactions	116238	18	1	19454	50	ATP2A1
4.529e-02	-3.09	FAA2 (medium-chain fatty acid-CoA ligase FAA2)	protein interactions	856734	18	1	19454	50	PDE9A
4.529e-02	-3.09	PPP1R3B (protein phosphatase 1 regulatory subunit 3B)	protein interactions	79660	18	1	19454	50	PLCE1
4.530e-02	-3.09	GHITM (growth hormone inducible transmembrane protein)	protein interactions	27069	132	2	19454	50	DPEP1,PDE2A
4.530e-02	-3.09	ADD3 (adducin 3)	protein interactions	120	132	2	19454	50	PRKCA,GSK3B
4.530e-02	-3.09	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	23	16828	47	PDE4B,TIAM2,PDE1A,PRKAR2A,PLCB1,CELF3,PLCE1,RXRA,NR4A2,PDE2A,ADCY8,RASGRF1,GUCY2F,SLC39A6,SLC18A2,PRKACB,PHACTR2,CBL,SMPDL3B,ATP2A1,KALRN,DPEP1,GUCY1A2
4.535e-02	-3.09	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	3	19454	50	PLCB1,SLC39A6,MINK1
4.547e-02	-3.09	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	hsa01521	79	2	7161	31	GSK3B,PRKCA
4.547e-02	-3.09	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	ko01521	79	2	7161	31	PRKCA,GSK3B
4.551e-02	-3.09	Z disc	cellular component	GO:0030018	130	2	19108	50	PDE4B,RYR2
4.560e-02	-3.09	fat cell differentiation	biological process	GO:0045444	124	2	18204	50	PLCB1,NR4A2
4.570e-02	-3.09	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	50	PDE2A
4.570e-02	-3.09	nuclear body organization	biological process	GO:0030575	17	1	18204	50	CELF3
4.570e-02	-3.09	regulation of fertilization	biological process	GO:0080154	17	1	18204	50	PLCB1
4.570e-02	-3.09	cellular response to reactive nitrogen species	biological process	GO:1902170	17	1	18204	50	DPEP1
4.570e-02	-3.09	positive regulation of meiotic nuclear division	biological process	GO:0045836	17	1	18204	50	PLCB1
4.570e-02	-3.09	positive regulation of cardiac muscle cell apoptotic process	biological process	GO:0010666	17	1	18204	50	CAMK2D
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	MINK1
4.570e-02	-3.09	fatty acid derivative catabolic process	biological process	GO:1901569	17	1	18204	50	DPEP1
4.570e-02	-3.09	positive regulation of striated muscle cell apoptotic process	biological process	GO:0010663	17	1	18204	50	CAMK2D
4.570e-02	-3.09	positive regulation of sequestering of calcium ion	biological process	GO:0051284	17	1	18204	50	RYR2
4.570e-02	-3.09	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	50	RYR2
4.591e-02	-3.08	PLD2 (phospholipase D2)	protein interactions	5338	133	2	19454	50	PLD3,PRKCA
4.591e-02	-3.08	VTA1 (vesicle trafficking 1)	protein interactions	51534	133	2	19454	50	PRKAR2A,GSK3B
4.604e-02	-3.08	RAB	prosite domains	PS51419	95	2	12186	44	MRAS,RAB37
4.605e-02	-3.08	TCR signaling in naive CD4+ T cells	Pathway Interaction DB	tcr_pathway	60	2	2226	13	CBL,PRKCA
4.607e-02	-3.08	PRKCI (protein kinase C iota)	protein interactions	5584	312	3	19454	50	PRKAR2A,PRKACB,PRKCA
4.626e-02	-3.07	cerebral cortex development	biological process	GO:0021987	125	2	18204	50	PLCB1,GSK3B
4.626e-02	-3.07	regulation of cell-matrix adhesion	biological process	GO:0001952	125	2	18204	50	GSK3B,MINK1
4.646e-02	-3.07	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	17	1	16828	47	CBL
4.646e-02	-3.07	chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	COSMIC cancer mutations	chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	17	1	16828	47	CBL
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	GSK3B,PDE2A
4.653e-02	-3.07	CNOT7 (CCR4-NOT transcription complex subunit 7)	protein interactions	29883	134	2	19454	50	MINK1,CBL
4.653e-02	-3.07	FDFT1 (farnesyl-diphosphate farnesyltransferase 1)	protein interactions	2222	134	2	19454	50	PLD3,ATP2A1
4.677e-02	-3.06	human chr20p12.3	chromosome location	human chr20p12.3	25	1	26134	50	PLCB1
4.695e-02	-3.06	skin-ear-malignant_melanoma	COSMIC cancer mutations	skin-ear-malignant_melanoma	124	2	16828	47	TIAM2,RASGRF1
4.701e-02	-3.06	AKT phosphorylates targets in the cytosol	REACTOME pathways	R-HSA-198323	13	1	10285	38	GSK3B
4.701e-02	-3.06	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	38	ITPR1
4.701e-02	-3.06	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	REACTOME pathways	R-HSA-2892247	13	1	10285	38	FOXD3
4.716e-02	-3.05	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	2	19454	50	MINK1,RASGRF1
4.727e-02	-3.05	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	4	10285	38	CAMK2D,GSK3B,ITPR1,RASGRF1
4.752e-02	-3.05	Iontro_rcpt_C	interpro domains	IPR001320	18	1	18521	50	GRIA3
4.752e-02	-3.05	Glu/Gly-bd	interpro domains	IPR019594	18	1	18521	50	GRIA3
4.752e-02	-3.05	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	1	18521	50	ATP2A1
4.752e-02	-3.05	Iono_Glu_rcpt_met	interpro domains	IPR001508	18	1	18521	50	GRIA3
4.752e-02	-3.05	Ionotropic_Glu_rcpt	interpro domains	IPR015683	18	1	18521	50	GRIA3
4.754e-02	-3.05	KIF5B (kinesin family member 5B)	protein interactions	3799	316	3	19454	50	GSK3B,PRKAR2A,PRKCA
4.760e-02	-3.05	cardiac ventricle development	biological process	GO:0003231	127	2	18204	50	RYR2,PDE2A
4.766e-02	-3.04	monoatomic anion:sodium symporter activity	molecular function	GO:0015373	18	1	18094	49	SLC18A2
4.766e-02	-3.04	5'-3' exonuclease activity	molecular function	GO:0008409	18	1	18094	49	PLD3
4.774e-02	-3.04	SGCE (sarcoglycan epsilon)	protein interactions	8910	19	1	19454	50	CBL
4.774e-02	-3.04	PLCB2 (phospholipase C beta 2)	protein interactions	5330	19	1	19454	50	PLCB1
4.774e-02	-3.04	MYOCD (myocardin)	protein interactions	93649	19	1	19454	50	GSK3B
4.774e-02	-3.04	JSRP1 (junctional sarcoplasmic reticulum protein 1)	protein interactions	126306	19	1	19454	50	PRKCA
4.774e-02	-3.04	ACADS (acyl-CoA dehydrogenase short chain)	protein interactions	35	19	1	19454	50	DPEP1
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	NGB
4.774e-02	-3.04	HELB (DNA helicase B)	protein interactions	92797	19	1	19454	50	GSK3B
4.774e-02	-3.04	RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)	protein interactions	6236	19	1	19454	50	PRKCA
4.774e-02	-3.04	CSF1 (colony stimulating factor 1)	protein interactions	1435	19	1	19454	50	CBL
4.774e-02	-3.04	CACNA1B (calcium voltage-gated channel subunit alpha1 B)	protein interactions	774	19	1	19454	50	CACNA1B
4.774e-02	-3.04	GNAL (G protein subunit alpha L)	protein interactions	2774	19	1	19454	50	CBL
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	PDE9A
4.774e-02	-3.04	PEX2 (peroxisomal biogenesis factor 2)	protein interactions	5828	19	1	19454	50	PDE2A
4.797e-02	-3.04	negative regulation of signaling	biological process	GO:0023057	1485	8	18204	50	NR4A2,CBL,GSK3B,PRKACB,SMPDL3B,ITPR1,PDE4B,PDE2A
4.797e-02	-3.04	negative regulation of cell communication	biological process	GO:0010648	1485	8	18204	50	PRKACB,GSK3B,NR4A2,CBL,PDE2A,PDE4B,ITPR1,SMPDL3B
4.822e-02	-3.03	regulation of hydrolase activity	biological process	GO:0051336	726	5	18204	50	DPEP1,LRCH1,TIAM2,GSK3B,RASGRF1
4.832e-02	-3.03	regulation of dopamine metabolic process	biological process	GO:0042053	18	1	18204	50	NR4A2
4.832e-02	-3.03	maintenance of cell polarity	biological process	GO:0030011	18	1	18204	50	GSK3B
4.832e-02	-3.03	regulation of endothelial cell development	biological process	GO:1901550	18	1	18204	50	PLCB1
4.832e-02	-3.03	retinoic acid receptor signaling pathway	biological process	GO:0048384	18	1	18204	50	RXRA
4.832e-02	-3.03	regulation of epidermal growth factor-activated receptor activity	biological process	GO:0007176	18	1	18204	50	CBL
4.832e-02	-3.03	type B pancreatic cell proliferation	biological process	GO:0044342	18	1	18204	50	RASGRF1
4.832e-02	-3.03	regulation of establishment of endothelial barrier	biological process	GO:1903140	18	1	18204	50	PLCB1
4.832e-02	-3.03	negative regulation of vascular permeability	biological process	GO:0043116	18	1	18204	50	PDE2A
4.832e-02	-3.03	regulation of catecholamine metabolic process	biological process	GO:0042069	18	1	18204	50	NR4A2
4.832e-02	-3.03	regulation of acrosome reaction	biological process	GO:0060046	18	1	18204	50	PLCB1
4.832e-02	-3.03	regulation of skeletal muscle contraction	biological process	GO:0014819	18	1	18204	50	ATP2A1
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	CAMK2D
4.842e-02	-3.03	CLUH (clustered mitochondria homolog)	protein interactions	23277	137	2	19454	50	PRKCA,FOXD3
4.844e-02	-3.03	Lig_chan-Glu_bd	pfam domains	PF10613	18	1	17795	49	GRIA3
4.844e-02	-3.03	Lig_chan	pfam domains	PF00060	18	1	17795	49	GRIA3
4.844e-02	-3.03	Cation_ATPase_N	pfam domains	PF00690	18	1	17795	49	ATP2A1
4.859e-02	-3.02	gamma-tubulin complex	cellular component	GO:0000930	19	1	19108	50	PDE4B
4.859e-02	-3.02	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	50	GRIA3
4.859e-02	-3.02	cytosolic region	cellular component	GO:0099522	19	1	19108	50	PLCB1
4.859e-02	-3.02	protein phosphatase type 1 complex	cellular component	GO:0000164	19	1	19108	50	SHOC2
4.870e-02	-3.02	ubiquitin protein ligase binding	molecular function	GO:0031625	303	3	18094	49	PRKAR2A,PRKACB,GSK3B
4.878e-02	-3.02	MFS_trans_sf	interpro domains	IPR036259	131	2	18521	50	SLC16A14,SLC18A2
4.890e-02	-3.02	nuclear membrane	cellular component	GO:0031965	314	3	19108	50	PLCB1,GUCY2F,ITPR1
4.905e-02	-3.01	SYAP1 (synapse associated protein 1)	protein interactions	94056	138	2	19454	50	ATP2A1,GSK3B
4.905e-02	-3.01	NCOA1 (nuclear receptor coactivator 1)	protein interactions	8648	138	2	19454	50	RXRA,NR4A2
4.905e-02	-3.01	AKAP12 (A-kinase anchoring protein 12)	protein interactions	9590	138	2	19454	50	PRKCA,PRKAR2A
4.906e-02	-3.01	DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A)	protein interactions	1859	538	4	19454	50	PRKACB,PRKAR2A,CAMK2D,LRCH1
4.932e-02	-3.01	AMP-activated Protein Kinase (AMPK) Signaling	WikiPathways	WP1403	68	2	5310	28	PLCB1,PRKACB
4.932e-02	-3.01	Association Between Physico-Chemical Features and Toxicity Associated Pathways	WikiPathways	WP3680	68	2	5310	28	GSK3B,CBL
4.934e-02	-3.01	serine/threonine protein kinase complex	cellular component	GO:1902554	136	2	19108	50	PRKACB,PRKAR2A
4.941e-02	-3.01	RASGEF	prosite domains	PS00720	14	1	12186	44	RASGRF1
4.962e-02	-3.00	detection of external stimulus	biological process	GO:0009581	130	2	18204	50	GUCY2F,CACNB4
4.968e-02	-3.00	ITGA6 (integrin subunit alpha 6)	protein interactions	3655	139	2	19454	50	CBL,ATP2A1
4.968e-02	-3.00	MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking)	protein interactions	23041	139	2	19454	50	PDE2A,PLD3
4.968e-02	-3.00	ERG28 (ergosterol biosynthesis 28 homolog)	protein interactions	11161	139	2	19454	50	GSK3B,CELF3
4.969e-02	-3.00	p75 NTR receptor-mediated signalling	REACTOME pathways	R-HSA-193704	97	2	10285	38	TIAM2,KALRN
4.969e-02	-3.00	Hypertrophic cardiomyopathy (HCM)	KEGG pathways	ko05410	83	2	7161	31	CACNB4,RYR2
4.969e-02	-3.00	Hypertrophic cardiomyopathy (HCM)	KEGG pathways	hsa05410	83	2	7161	31	RYR2,CACNB4
4.998e-02	-3.00	molecular function inhibitor activity	molecular function	GO:0140678	514	4	18094	49	PRKAR2A,CAMK2D,PHACTR2,ITPR1