TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols hsa04713 Circadian entrainment 4.0896169866586e-12 -26.2225697965527 96 10 0.32258064516129 31 7161 5578,5567,23236,6262,51655,2892,817,114,2977,3708 PRKCA,PRKACB,PLCB1,RYR2,RASD1,GRIA3,CAMK2D,ADCY8,GUCY1A2,ITPR1 ko04713 Circadian entrainment 4.0896169866586e-12 -26.2225697965527 96 10 0.32258064516129 31 7161 3708,2977,114,5567,5578,6262,23236,817,2892,51655 ITPR1,GUCY1A2,ADCY8,PRKACB,PRKCA,RYR2,PLCB1,CAMK2D,GRIA3,RASD1 ko04020 Calcium signaling pathway 1.08365355661514e-10 -22.9455126752236 181 11 0.354838709677419 31 7161 114,3708,774,817,5136,51196,5578,5567,487,23236,6262 ADCY8,ITPR1,CACNA1B,CAMK2D,PDE1A,PLCE1,PRKCA,PRKACB,ATP2A1,PLCB1,RYR2 hsa04020 Calcium signaling pathway 1.08365355661514e-10 -22.9455126752236 181 11 0.354838709677419 31 7161 774,3708,114,817,6262,23236,487,5567,5578,51196,5136 CACNA1B,ITPR1,ADCY8,CAMK2D,RYR2,PLCB1,ATP2A1,PRKACB,PRKCA,PLCE1,PDE1A hsa04925 Aldosterone synthesis and secretion 1.33077297604046e-09 -20.4375058785425 82 8 0.258064516129032 31 7161 23236,5578,5567,817,4929,3708,5138,114 PLCB1,PRKCA,PRKACB,CAMK2D,NR4A2,ITPR1,PDE2A,ADCY8 ko04925 Aldosterone synthesis and secretion 1.33077297604046e-09 -20.4375058785425 82 8 0.258064516129032 31 7161 817,23236,5567,5578,4929,3708,5138,114 CAMK2D,PLCB1,PRKACB,PRKCA,NR4A2,ITPR1,PDE2A,ADCY8 ko04728 Dopaminergic synapse 2.33279637915882e-09 -19.8761981262593 130 9 0.290322580645161 31 7161 23236,5567,5578,6571,817,2892,2932,774,3708 PLCB1,PRKACB,PRKCA,SLC18A2,CAMK2D,GRIA3,GSK3B,CACNA1B,ITPR1 hsa04728 Dopaminergic synapse 2.33279637915882e-09 -19.8761981262593 130 9 0.290322580645161 31 7161 3708,2932,774,5578,5567,23236,817,2892,6571 ITPR1,GSK3B,CACNA1B,PRKCA,PRKACB,PLCB1,CAMK2D,GRIA3,SLC18A2 ko04921 Oxytocin signaling pathway 9.3387756902878e-09 -18.489090675708 152 9 0.290322580645161 31 7161 3708,2977,114,785,5567,5578,6262,23236,817 ITPR1,GUCY1A2,ADCY8,CACNB4,PRKACB,PRKCA,RYR2,PLCB1,CAMK2D hsa04921 Oxytocin signaling pathway 9.3387756902878e-09 -18.489090675708 152 9 0.290322580645161 31 7161 5567,5578,23236,6262,817,2977,114,3708,785 PRKACB,PRKCA,PLCB1,RYR2,CAMK2D,GUCY1A2,ADCY8,ITPR1,CACNB4 ko05032 Morphine addiction 8.69662811810589e-08 -16.257745366049 91 7 0.225806451612903 31 7161 5142,774,5567,5578,5136,114,5138 PDE4B,CACNA1B,PRKACB,PRKCA,PDE1A,ADCY8,PDE2A hsa05032 Morphine addiction 8.69662811810589e-08 -16.257745366049 91 7 0.225806451612903 31 7161 5578,5567,5138,5136,114,774,5142 PRKCA,PRKACB,PDE2A,PDE1A,ADCY8,CACNA1B,PDE4B ko04723 Retrograde endocannabinoid signaling 1.79412773858587e-07 -15.5335766866314 101 7 0.225806451612903 31 7161 23236,774,114,5578,5567,3708,2892 PLCB1,CACNA1B,ADCY8,PRKCA,PRKACB,ITPR1,GRIA3 hsa04723 Retrograde endocannabinoid signaling 1.79412773858587e-07 -15.5335766866314 101 7 0.225806451612903 31 7161 23236,774,5567,5578,3708,114,2892 PLCB1,CACNA1B,PRKACB,PRKCA,ITPR1,ADCY8,GRIA3 hsa04720 Long-term potentiation 3.27307136483643e-07 -14.9323668515717 67 6 0.193548387096774 31 7161 23236,114,3708,5578,5567,817 PLCB1,ADCY8,ITPR1,PRKCA,PRKACB,CAMK2D ko04720 Long-term potentiation 3.27307136483643e-07 -14.9323668515717 67 6 0.193548387096774 31 7161 817,114,5578,5567,3708,23236 CAMK2D,ADCY8,PRKCA,PRKACB,ITPR1,PLCB1 hsa04726 Serotonergic synapse 3.65786561009578e-07 -14.8212158402933 112 7 0.225806451612903 31 7161 3751,6571,3708,5567,5578,774,23236 KCND2,SLC18A2,ITPR1,PRKACB,PRKCA,CACNA1B,PLCB1 hsa04725 Cholinergic synapse 3.65786561009578e-07 -14.8212158402933 112 7 0.225806451612903 31 7161 114,5578,3708,5567,23236,774,817 ADCY8,PRKCA,ITPR1,PRKACB,PLCB1,CACNA1B,CAMK2D ko04971 Gastric acid secretion 6.44697138511552e-07 -14.2544851831203 75 6 0.193548387096774 31 7161 817,5578,3708,5567,114,23236 CAMK2D,PRKCA,ITPR1,PRKACB,ADCY8,PLCB1 hsa04971 Gastric acid secretion 6.44697138511552e-07 -14.2544851831203 75 6 0.193548387096774 31 7161 817,23236,114,5578,3708,5567 CAMK2D,PLCB1,ADCY8,PRKCA,ITPR1,PRKACB hsa04911 Insulin secretion 1.3587337611671e-06 -13.5089573498854 85 6 0.193548387096774 31 7161 5578,5567,114,6262,23236,817 PRKCA,PRKACB,ADCY8,RYR2,PLCB1,CAMK2D ko04540 Gap junction 1.66847581706182e-06 -13.3036000326797 88 6 0.193548387096774 31 7161 23236,5567,3708,5578,2977,114 PLCB1,PRKACB,ITPR1,PRKCA,GUCY1A2,ADCY8 hsa04540 Gap junction 1.66847581706182e-06 -13.3036000326797 88 6 0.193548387096774 31 7161 23236,2977,114,3708,5578,5567 PLCB1,GUCY1A2,ADCY8,ITPR1,PRKCA,PRKACB hsa04970 Salivary secretion 1.90536146781195e-06 -13.1708388205024 90 6 0.193548387096774 31 7161 23236,5567,5578,3708,2977,114 PLCB1,PRKACB,PRKCA,ITPR1,GUCY1A2,ADCY8 ko04970 Salivary secretion 1.90536146781195e-06 -13.1708388205024 90 6 0.193548387096774 31 7161 2977,114,5567,3708,5578,23236 GUCY1A2,ADCY8,PRKACB,ITPR1,PRKCA,PLCB1 ko04261 Adrenergic signaling in cardiomyocytes 2.01721845089134e-06 -13.1137910000023 144 7 0.225806451612903 31 7161 817,114,5567,5578,785,23236,6262 CAMK2D,ADCY8,PRKACB,PRKCA,CACNB4,PLCB1,RYR2 hsa04261 Adrenergic signaling in cardiomyocytes 2.01721845089134e-06 -13.1137910000023 144 7 0.225806451612903 31 7161 6262,23236,785,5578,5567,114,817 RYR2,PLCB1,CACNB4,PRKCA,PRKACB,ADCY8,CAMK2D hsa04912 GnRH signaling pathway 2.16905844801347e-06 -13.0412173794962 92 6 0.193548387096774 31 7161 5578,3708,5567,114,23236,817 PRKCA,ITPR1,PRKACB,ADCY8,PLCB1,CAMK2D ko04912 GnRH signaling pathway 2.16905844801347e-06 -13.0412173794962 92 6 0.193548387096774 31 7161 23236,3708,5567,5578,114,817 PLCB1,ITPR1,PRKACB,PRKCA,ADCY8,CAMK2D ko04972 Pancreatic secretion 2.61990919042141e-06 -12.8523709009364 95 6 0.193548387096774 31 7161 114,3708,487,5578,23236,6262 ADCY8,ITPR1,ATP2A1,PRKCA,PLCB1,RYR2 hsa04972 Pancreatic secretion 2.61990919042141e-06 -12.8523709009364 95 6 0.193548387096774 31 7161 114,487,5578,3708,23236,6262 ADCY8,ATP2A1,PRKCA,ITPR1,PLCB1,RYR2 ko04750 Inflammatory mediator regulation of TRP channels 2.96091959585793e-06 -12.7300106636012 97 6 0.193548387096774 31 7161 23236,3708,5578,5567,114,817 PLCB1,ITPR1,PRKCA,PRKACB,ADCY8,CAMK2D hsa04750 Inflammatory mediator regulation of TRP channels 2.96091959585793e-06 -12.7300106636012 97 6 0.193548387096774 31 7161 5567,3708,5578,114,23236,817 PRKACB,ITPR1,PRKCA,ADCY8,PLCB1,CAMK2D hsa04916 Melanogenesis 3.75187861678696e-06 -12.4932538789462 101 6 0.193548387096774 31 7161 23236,2932,114,5567,5578,817 PLCB1,GSK3B,ADCY8,PRKACB,PRKCA,CAMK2D ko04916 Melanogenesis 3.75187861678696e-06 -12.4932538789462 101 6 0.193548387096774 31 7161 5578,5567,114,2932,23236,817 PRKCA,PRKACB,ADCY8,GSK3B,PLCB1,CAMK2D ko04730 Long-term depression 5.01141813401171e-06 -12.2037916222406 60 5 0.161290322580645 31 7161 2892,23236,2977,3708,5578 GRIA3,PLCB1,GUCY1A2,ITPR1,PRKCA hsa04730 Long-term depression 5.01141813401171e-06 -12.2037916222406 60 5 0.161290322580645 31 7161 2892,23236,2977,5578,3708 GRIA3,PLCB1,GUCY1A2,PRKCA,ITPR1 hsa00230 Purine metabolism 6.85503541560326e-06 -11.8905270785734 173 7 0.225806451612903 31 7161 114,5138,5136,2977,5142,5152,2986 ADCY8,PDE2A,PDE1A,GUCY1A2,PDE4B,PDE9A,GUCY2F ko00230 Purine metabolism 6.85503541560326e-06 -11.8905270785734 173 7 0.225806451612903 31 7161 114,5138,5136,2977,2986,5152,5142 ADCY8,PDE2A,PDE1A,GUCY1A2,GUCY2F,PDE9A,PDE4B hsa04924 Renin secretion 7.46492910057997e-06 -11.8052946245963 65 5 0.161290322580645 31 7161 23236,5136,2977,5567,3708 PLCB1,PDE1A,GUCY1A2,PRKACB,ITPR1 ko04924 Renin secretion 7.46492910057997e-06 -11.8052946245963 65 5 0.161290322580645 31 7161 23236,3708,5567,2977,5136 PLCB1,ITPR1,PRKACB,GUCY1A2,PDE1A hsa04724 Glutamatergic synapse 7.59161960036305e-06 -11.7884656032382 114 6 0.193548387096774 31 7161 114,5578,3708,5567,23236,2892 ADCY8,PRKCA,ITPR1,PRKACB,PLCB1,GRIA3 ko04724 Glutamatergic synapse 7.59161960036305e-06 -11.7884656032382 114 6 0.193548387096774 31 7161 23236,5567,3708,5578,114,2892 PLCB1,PRKACB,ITPR1,PRKCA,ADCY8,GRIA3 hsa04919 Thyroid hormone signaling pathway 8.39556014368395e-06 -11.6878075461724 116 6 0.193548387096774 31 7161 51196,5578,5567,23236,2932,6256 PLCE1,PRKCA,PRKACB,PLCB1,GSK3B,RXRA ko05031 Amphetamine addiction 9.33540333261381e-06 -11.5816965754108 68 5 0.161290322580645 31 7161 6571,817,2892,5578,5567 SLC18A2,CAMK2D,GRIA3,PRKCA,PRKACB hsa05031 Amphetamine addiction 9.33540333261381e-06 -11.5816965754108 68 5 0.161290322580645 31 7161 6571,817,2892,5567,5578 SLC18A2,CAMK2D,GRIA3,PRKACB,PRKCA hsa04270 Vascular smooth muscle contraction 1.07115971318385e-05 -11.4441835593343 121 6 0.193548387096774 31 7161 23236,5567,5578,3708,114,2977 PLCB1,PRKACB,PRKCA,ITPR1,ADCY8,GUCY1A2 ko04270 Vascular smooth muscle contraction 1.07115971318385e-05 -11.4441835593343 121 6 0.193548387096774 31 7161 5578,3708,5567,114,2977,23236 PRKCA,ITPR1,PRKACB,ADCY8,GUCY1A2,PLCB1 ko04918 Thyroid hormone synthesis 1.41657059622732e-05 -11.1646865874293 74 5 0.161290322580645 31 7161 23236,114,5567,3708,5578 PLCB1,ADCY8,PRKACB,ITPR1,PRKCA hsa04918 Thyroid hormone synthesis 1.41657059622732e-05 -11.1646865874293 74 5 0.161290322580645 31 7161 23236,114,5578,5567,3708 PLCB1,ADCY8,PRKCA,PRKACB,ITPR1 ko04024 cAMP signaling pathway 1.66270395453066e-05 -11.0044802995299 198 7 0.225806451612903 31 7161 114,51196,5567,6262,2892,5142,817 ADCY8,PLCE1,PRKACB,RYR2,GRIA3,PDE4B,CAMK2D hsa04024 cAMP signaling pathway 1.66270395453066e-05 -11.0044802995299 198 7 0.225806451612903 31 7161 2892,5142,817,6262,114,51196,5567 GRIA3,PDE4B,CAMK2D,RYR2,ADCY8,PLCE1,PRKACB hsa05205 Proteoglycans in cancer 1.95575554743066e-05 -10.8421488769189 203 7 0.225806451612903 31 7161 51196,3708,5578,5567,817,22808,867 PLCE1,ITPR1,PRKCA,PRKACB,CAMK2D,MRAS,CBL ko05205 Proteoglycans in cancer 1.95575554743066e-05 -10.8421488769189 203 7 0.225806451612903 31 7161 3708,5578,5567,51196,817,867,22808 ITPR1,PRKCA,PRKACB,PLCE1,CAMK2D,CBL,MRAS hsa04371 Apelin signaling pathway 2.27480550522396e-05 -10.6910309084312 138 6 0.193548387096774 31 7161 22808,6262,23236,5567,3708,114 MRAS,RYR2,PLCB1,PRKACB,ITPR1,ADCY8 hsa04022 cGMP-PKG signaling pathway 5.82624675965397e-05 -9.7505524524288 163 6 0.193548387096774 31 7161 23236,487,3708,114,2977,5138 PLCB1,ATP2A1,ITPR1,ADCY8,GUCY1A2,PDE2A ko04022 cGMP-PKG signaling pathway 5.82624675965397e-05 -9.7505524524288 163 6 0.193548387096774 31 7161 23236,114,2977,5138,3708,487 PLCB1,ADCY8,GUCY1A2,PDE2A,ITPR1,ATP2A1 hsa04611 Platelet activation 0.000163707464368026 -8.71742947677685 123 5 0.161290322580645 31 7161 5567,3708,2977,114,23236 PRKACB,ITPR1,GUCY1A2,ADCY8,PLCB1 ko04310 Wnt signaling pathway 0.000331012506107261 -8.01335440049957 143 5 0.161290322580645 31 7161 5567,5578,23236,2932,817 PRKACB,PRKCA,PLCB1,GSK3B,CAMK2D hsa04310 Wnt signaling pathway 0.000331012506107261 -8.01335440049957 143 5 0.161290322580645 31 7161 23236,2932,5578,5567,817 PLCB1,GSK3B,PRKCA,PRKACB,CAMK2D hsa04014 Ras signaling pathway 0.000351043875997803 -7.95459933946787 226 6 0.193548387096774 31 7161 51196,5578,5567,8036,5923,22808 PLCE1,PRKCA,PRKACB,SHOC2,RASGRF1,MRAS hsa04012 ErbB signaling pathway 0.000455633305334207 -7.69382222692478 85 4 0.129032258064516 31 7161 817,867,5578,2932 CAMK2D,CBL,PRKCA,GSK3B ko04012 ErbB signaling pathway 0.000455633305334207 -7.69382222692478 85 4 0.129032258064516 31 7161 817,867,5578,2932 CAMK2D,CBL,PRKCA,GSK3B hsa04727 GABAergic synapse 0.000520009690568582 -7.56166311085363 88 4 0.129032258064516 31 7161 114,5578,5567,774 ADCY8,PRKCA,PRKACB,CACNA1B ko04727 GABAergic synapse 0.000520009690568582 -7.56166311085363 88 4 0.129032258064516 31 7161 5567,5578,114,774 PRKACB,PRKCA,ADCY8,CACNA1B ko05414 Dilated cardiomyopathy 0.000542839592955612 -7.51869669059367 89 4 0.129032258064516 31 7161 785,6262,114,5567 CACNB4,RYR2,ADCY8,PRKACB hsa05414 Dilated cardiomyopathy 0.000542839592955612 -7.51869669059367 89 4 0.129032258064516 31 7161 6262,785,5567,114 RYR2,CACNB4,PRKACB,ADCY8 M00694 cGMP signaling 0.00064074253918184 -7.35288283667108 9 2 0.0645161290322581 31 7161 2977,5138 GUCY1A2,PDE2A hsa_M00694 cGMP signaling 0.00064074253918184 -7.35288283667108 9 2 0.0645161290322581 31 7161 5138,2977 PDE2A,GUCY1A2 hsa04010 MAPK signaling pathway 0.00066838992123227 -7.31063884030306 255 6 0.193548387096774 31 7161 5923,22808,5567,5578,774,785 RASGRF1,MRAS,PRKACB,PRKCA,CACNA1B,CACNB4 ko04010 MAPK signaling pathway 0.00066838992123227 -7.31063884030306 255 6 0.193548387096774 31 7161 5923,22808,5578,5567,774,785 RASGRF1,MRAS,PRKCA,PRKACB,CACNA1B,CACNB4 hsa04070 Phosphatidylinositol signaling system 0.000751949308573647 -7.19284164509815 97 4 0.129032258064516 31 7161 23236,3708,5578,51196 PLCB1,ITPR1,PRKCA,PLCE1 ko04070 Phosphatidylinositol signaling system 0.000751949308573647 -7.19284164509815 97 4 0.129032258064516 31 7161 3708,5578,51196,23236 ITPR1,PRKCA,PLCE1,PLCB1 hsa04915 Estrogen signaling pathway 0.000781584687208997 -7.15418704902307 98 4 0.129032258064516 31 7161 23236,5567,3708,114 PLCB1,PRKACB,ITPR1,ADCY8 ko04915 Estrogen signaling pathway 0.000781584687208997 -7.15418704902307 98 4 0.129032258064516 31 7161 3708,5567,114,23236 ITPR1,PRKACB,ADCY8,PLCB1 hsa04922 Glucagon signaling pathway 0.00090844252138531 -7.00377893972963 102 4 0.129032258064516 31 7161 817,3708,5567,23236 CAMK2D,ITPR1,PRKACB,PLCB1 ko04922 Glucagon signaling pathway 0.00090844252138531 -7.00377893972963 102 4 0.129032258064516 31 7161 817,3708,5567,23236 CAMK2D,ITPR1,PRKACB,PLCB1 hsa04961 Endocrine and other factor-regulated calcium reabsorption 0.00104717849524674 -6.86165587905811 47 3 0.0967741935483871 31 7161 5578,5567,23236 PRKCA,PRKACB,PLCB1 ko04961 Endocrine and other factor-regulated calcium reabsorption 0.00104717849524674 -6.86165587905811 47 3 0.0967741935483871 31 7161 5567,5578,23236 PRKACB,PRKCA,PLCB1 hsa05200 Pathways in cancer 0.00122141731795285 -6.70774335850316 395 7 0.225806451612903 31 7161 867,6256,114,5567,5578,23236,2932 CBL,RXRA,ADCY8,PRKACB,PRKCA,PLCB1,GSK3B ko04114 Oocyte meiosis 0.00166322462415728 -6.3989970162407 120 4 0.129032258064516 31 7161 817,3708,5567,114 CAMK2D,ITPR1,PRKACB,ADCY8 hsa04114 Oocyte meiosis 0.00166322462415728 -6.3989970162407 120 4 0.129032258064516 31 7161 817,114,5567,3708 CAMK2D,ADCY8,PRKACB,ITPR1 ko04015 Rap1 signaling pathway 0.00188582769082243 -6.2733884611809 210 5 0.161290322580645 31 7161 23236,51196,114,5578,22808 PLCB1,PLCE1,ADCY8,PRKCA,MRAS hsa04015 Rap1 signaling pathway 0.00188582769082243 -6.2733884611809 210 5 0.161290322580645 31 7161 22808,51196,114,5578,23236 MRAS,PLCE1,ADCY8,PRKCA,PLCB1 hsa_M00695 cAMP signaling 0.00209585241465065 -6.16779492785996 16 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB M00695 cAMP signaling 0.00209585241465065 -6.16779492785996 16 2 0.0645161290322581 31 7161 5567,114 PRKACB,ADCY8 hsa04910 Insulin signaling pathway 0.00277365354425719 -5.88758985881254 138 4 0.129032258064516 31 7161 5576,867,5567,2932 PRKAR2A,CBL,PRKACB,GSK3B ko04910 Insulin signaling pathway 0.00277365354425719 -5.88758985881254 138 4 0.129032258064516 31 7161 2932,5567,867,5576 GSK3B,PRKACB,CBL,PRKAR2A hsa04072 Phospholipase D signaling pathway 0.00331718674422405 -5.70863822146899 145 4 0.129032258064516 31 7161 23236,5578,114,22808 PLCB1,PRKCA,ADCY8,MRAS ko04072 Phospholipase D signaling pathway 0.00331718674422405 -5.70863822146899 145 4 0.129032258064516 31 7161 22808,23236,114,5578 MRAS,PLCB1,ADCY8,PRKCA hsa04976 Bile secretion 0.00344102639537321 -5.6719854813525 71 3 0.0967741935483871 31 7161 6256,5567,114 RXRA,PRKACB,ADCY8 ko04976 Bile secretion 0.00344102639537321 -5.6719854813525 71 3 0.0967741935483871 31 7161 6256,5567,114 RXRA,PRKACB,ADCY8 M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 0.00396983448598565 -5.52903087633963 22 2 0.0645161290322581 31 7161 51196,23236 PLCE1,PLCB1 hsa_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 0.00396983448598565 -5.52903087633963 22 2 0.0645161290322581 31 7161 23236,51196 PLCB1,PLCE1 hsa04742 Taste transduction 0.00516333264294515 -5.26617304693126 82 3 0.0967741935483871 31 7161 114,5136,5567 ADCY8,PDE1A,PRKACB ko04742 Taste transduction 0.00516333264294515 -5.26617304693126 82 3 0.0967741935483871 31 7161 114,5136,5567 ADCY8,PDE1A,PRKACB hsa05010 Alzheimer's disease 0.00526345455807369 -5.24696770771499 165 4 0.129032258064516 31 7161 3708,487,23236,2932 ITPR1,ATP2A1,PLCB1,GSK3B ko05010 Alzheimer's disease 0.00526345455807369 -5.24696770771499 165 4 0.129032258064516 31 7161 23236,2932,487,3708 PLCB1,GSK3B,ATP2A1,ITPR1 ko04062 Chemokine signaling pathway 0.00742815455961367 -4.90247782800572 182 4 0.129032258064516 31 7161 23236,2932,114,5567 PLCB1,GSK3B,ADCY8,PRKACB hsa04062 Chemokine signaling pathway 0.00742815455961367 -4.90247782800572 182 4 0.129032258064516 31 7161 2932,23236,5567,114 GSK3B,PLCB1,PRKACB,ADCY8 hsa05146 Amoebiasis 0.00754656170780161 -4.8866632223888 94 3 0.0967741935483871 31 7161 5567,5578,23236 PRKACB,PRKCA,PLCB1 ko05146 Amoebiasis 0.00754656170780161 -4.8866632223888 94 3 0.0967741935483871 31 7161 5567,5578,23236 PRKACB,PRKCA,PLCB1 ko04933 AGE-RAGE signaling pathway in diabetic complications 0.00870281309819768 -4.74410896096578 99 3 0.0967741935483871 31 7161 23236,51196,5578 PLCB1,PLCE1,PRKCA hsa04933 AGE-RAGE signaling pathway in diabetic complications 0.00870281309819768 -4.74410896096578 99 3 0.0967741935483871 31 7161 51196,5578,23236 PLCE1,PRKCA,PLCB1 ko05143 African trypanosomiasis 0.009335031755841 -4.67398110019017 34 2 0.0645161290322581 31 7161 23236,5578 PLCB1,PRKCA hsa05143 African trypanosomiasis 0.009335031755841 -4.67398110019017 34 2 0.0645161290322581 31 7161 5578,23236 PRKCA,PLCB1 hsa05033 Nicotine addiction 0.0127720102307317 -4.36049920310176 40 2 0.0645161290322581 31 7161 2892,774 GRIA3,CACNA1B ko05033 Nicotine addiction 0.0127720102307317 -4.36049920310176 40 2 0.0645161290322581 31 7161 774,2892 CACNA1B,GRIA3 hsa04140 Autophagy - animal 0.0170514235329217 -4.07152158707089 127 3 0.0967741935483871 31 7161 3708,5567,22808 ITPR1,PRKACB,MRAS ko04140 Autophagy - animal 0.0170514235329217 -4.07152158707089 127 3 0.0967741935483871 31 7161 5567,3708,22808 PRKACB,ITPR1,MRAS ko04340 Hedgehog signaling pathway 0.0173720280958209 -4.05289394700596 47 2 0.0645161290322581 31 7161 2932,5567 GSK3B,PRKACB hsa04340 Hedgehog signaling pathway 0.0173720280958209 -4.05289394700596 47 2 0.0645161290322581 31 7161 2932,5567 GSK3B,PRKACB hsa05030 Cocaine addiction 0.0187978902226529 -3.97401063764293 49 2 0.0645161290322581 31 7161 6571,5567 SLC18A2,PRKACB ko05030 Cocaine addiction 0.0187978902226529 -3.97401063764293 49 2 0.0645161290322581 31 7161 5567,6571 PRKACB,SLC18A2 ko04913 Ovarian steroidogenesis 0.0195288555989431 -3.93586213289475 50 2 0.0645161290322581 31 7161 5567,114 PRKACB,ADCY8 hsa04913 Ovarian steroidogenesis 0.0195288555989431 -3.93586213289475 50 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB hsa05110 Vibrio cholerae infection 0.0202716967845179 -3.89852961286931 51 2 0.0645161290322581 31 7161 5567,5578 PRKACB,PRKCA ko05110 Vibrio cholerae infection 0.0202716967845179 -3.89852961286931 51 2 0.0645161290322581 31 7161 5578,5567 PRKCA,PRKACB hsa04923 Regulation of lipolysis in adipocytes 0.0225703839950934 -3.79111667477977 54 2 0.0645161290322581 31 7161 5567,114 PRKACB,ADCY8 ko05166 HTLV-I infection 0.0235028685799276 -3.75063279805066 256 4 0.129032258064516 31 7161 22808,5567,114,2932 MRAS,PRKACB,ADCY8,GSK3B hsa05166 HTLV-I infection 0.0235028685799276 -3.75063279805066 256 4 0.129032258064516 31 7161 2932,5567,114,22808 GSK3B,PRKACB,ADCY8,MRAS hsa05223 Non-small cell lung cancer 0.025794997652124 -3.65757469530611 58 2 0.0645161290322581 31 7161 6256,5578 RXRA,PRKCA ko05223 Non-small cell lung cancer 0.025794997652124 -3.65757469530611 58 2 0.0645161290322581 31 7161 6256,5578 RXRA,PRKCA hsa04213 Longevity regulating pathway - multiple species 0.0291959246375381 -3.53372614665591 62 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB ko04213 Longevity regulating pathway - multiple species 0.0291959246375381 -3.53372614665591 62 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB hsa04721 Synaptic vesicle cycle 0.0300729275892945 -3.5041299275823 63 2 0.0645161290322581 31 7161 774,6571 CACNA1B,SLC18A2 ko04721 Synaptic vesicle cycle 0.0300729275892945 -3.5041299275823 63 2 0.0645161290322581 31 7161 6571,774 SLC18A2,CACNA1B hsa05214 Glioma 0.0309604348232436 -3.47504518568083 64 2 0.0645161290322581 31 7161 5578,817 PRKCA,CAMK2D ko05214 Glioma 0.0309604348232436 -3.47504518568083 64 2 0.0645161290322581 31 7161 817,5578 CAMK2D,PRKCA hsa00562 Inositol phosphate metabolism 0.0374587006857754 -3.28451626794481 71 2 0.0645161290322581 31 7161 23236,51196 PLCB1,PLCE1 ko00562 Inositol phosphate metabolism 0.0374587006857754 -3.28451626794481 71 2 0.0645161290322581 31 7161 23236,51196 PLCB1,PLCE1 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.0384266587676508 -3.25900382151979 72 2 0.0645161290322581 31 7161 785,6262 CACNB4,RYR2 ko05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.0384266587676508 -3.25900382151979 72 2 0.0645161290322581 31 7161 6262,785 RYR2,CACNB4 hsa04360 Axon guidance 0.0385227565487238 -3.25650613311926 174 3 0.0967741935483871 31 7161 817,5578,2932 CAMK2D,PRKCA,GSK3B ko04360 Axon guidance 0.0385227565487238 -3.25650613311926 174 3 0.0967741935483871 31 7161 5578,2932,817 PRKCA,GSK3B,CAMK2D hsa04260 Cardiac muscle contraction 0.0403913324977204 -3.20914005916812 74 2 0.0645161290322581 31 7161 785,6262 CACNB4,RYR2 ko04260 Cardiac muscle contraction 0.0403913324977204 -3.20914005916812 74 2 0.0645161290322581 31 7161 6262,785 RYR2,CACNB4 ko01521 EGFR tyrosine kinase inhibitor resistance 0.0454663562371969 -3.09078264989183 79 2 0.0645161290322581 31 7161 5578,2932 PRKCA,GSK3B hsa01521 EGFR tyrosine kinase inhibitor resistance 0.0454663562371969 -3.09078264989183 79 2 0.0645161290322581 31 7161 2932,5578 GSK3B,PRKCA hsa05410 Hypertrophic cardiomyopathy (HCM) 0.0496882570340802 -3.00198665077763 83 2 0.0645161290322581 31 7161 6262,785 RYR2,CACNB4 ko05410 Hypertrophic cardiomyopathy (HCM) 0.0496882570340802 -3.00198665077763 83 2 0.0645161290322581 31 7161 785,6262 CACNB4,RYR2 ko04510 Focal adhesion 0.0530814655238039 -2.93592746018179 198 3 0.0967741935483871 31 7161 5923,5578,2932 RASGRF1,PRKCA,GSK3B hsa04510 Focal adhesion 0.0530814655238039 -2.93592746018179 198 3 0.0967741935483871 31 7161 5923,5578,2932 RASGRF1,PRKCA,GSK3B hsa04211 Longevity regulating pathway 0.0562773612140562 -2.87746293457902 89 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB hsa04914 Progesterone-mediated oocyte maturation 0.0596820919195595 -2.81872327142951 92 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB ko04914 Progesterone-mediated oocyte maturation 0.0596820919195595 -2.81872327142951 92 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB hsa01522 Endocrine resistance 0.0631571947650022 -2.76212850532137 95 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB ko01522 Endocrine resistance 0.0631571947650022 -2.76212850532137 95 2 0.0645161290322581 31 7161 114,5567 ADCY8,PRKACB hsa04066 HIF-1 signaling pathway 0.0703095394280914 -2.65484779338147 101 2 0.0645161290322581 31 7161 817,5578 CAMK2D,PRKCA hsa04660 T cell receptor signaling pathway 0.0715268504224626 -2.63768236939197 102 2 0.0645161290322581 31 7161 867,2932 CBL,GSK3B ko04660 T cell receptor signaling pathway 0.0715268504224626 -2.63768236939197 102 2 0.0645161290322581 31 7161 2932,867 GSK3B,CBL hsa04071 Sphingolipid signaling pathway 0.0919037263448586 -2.38701370262035 118 2 0.0645161290322581 31 7161 5578,23236 PRKCA,PLCB1 ko04071 Sphingolipid signaling pathway 0.0919037263448586 -2.38701370262035 118 2 0.0645161290322581 31 7161 5578,23236 PRKCA,PLCB1 ko04722 Neurotrophin signaling pathway 0.0932296973906487 -2.37268896651546 119 2 0.0645161290322581 31 7161 2932,817 GSK3B,CAMK2D hsa04722 Neurotrophin signaling pathway 0.0932296973906487 -2.37268896651546 119 2 0.0645161290322581 31 7161 2932,817 GSK3B,CAMK2D ko04740 Olfactory transduction 0.101848020826314 -2.28427356873854 415 4 0.129032258064516 31 7161 5138,5136,5567,817 PDE2A,PDE1A,PRKACB,CAMK2D hsa04740 Olfactory transduction 0.101848020826314 -2.28427356873854 415 4 0.129032258064516 31 7161 817,5138,5136,5567 CAMK2D,PDE2A,PDE1A,PRKACB hsa05012 Parkinson's disease 0.10679309558426 -2.23686200263327 129 2 0.0645161290322581 31 7161 5567,6571 PRKACB,SLC18A2 hsa05160 Hepatitis C 0.109568483695196 -2.2112055033464 131 2 0.0645161290322581 31 7161 2932,6256 GSK3B,RXRA ko05160 Hepatitis C 0.109568483695196 -2.2112055033464 131 2 0.0645161290322581 31 7161 2932,6256 GSK3B,RXRA ko04744 Phototransduction 0.114590774650728 -2.16638797837178 28 1 0.032258064516129 31 7161 2986 GUCY2F hsa04744 Phototransduction 0.114590774650728 -2.16638797837178 28 1 0.032258064516129 31 7161 2986 GUCY2F hsa05216 Thyroid cancer 0.118438760911399 -2.13335923754445 29 1 0.032258064516129 31 7161 6256 RXRA ko05216 Thyroid cancer 0.118438760911399 -2.13335923754445 29 1 0.032258064516129 31 7161 6256 RXRA ko04932 Non-alcoholic fatty liver disease (NAFLD) 0.129518123238254 -2.04393445984858 145 2 0.0645161290322581 31 7161 6256,2932 RXRA,GSK3B hsa04932 Non-alcoholic fatty liver disease (NAFLD) 0.129518123238254 -2.04393445984858 145 2 0.0645161290322581 31 7161 6256,2932 RXRA,GSK3B hsa04150 mTOR signaling pathway 0.136843753489958 -1.98891548947723 150 2 0.0645161290322581 31 7161 5578,2932 PRKCA,GSK3B ko04150 mTOR signaling pathway 0.136843753489958 -1.98891548947723 150 2 0.0645161290322581 31 7161 2932,5578 GSK3B,PRKCA ko05020 Prion diseases 0.141189064263488 -1.95765540548115 35 1 0.032258064516129 31 7161 5567 PRKACB hsa05020 Prion diseases 0.141189064263488 -1.95765540548115 35 1 0.032258064516129 31 7161 5567 PRKACB hsa04960 Aldosterone-regulated sodium reabsorption 0.148645446608083 -1.90619136163798 37 1 0.032258064516129 31 7161 5578 PRKCA ko04960 Aldosterone-regulated sodium reabsorption 0.148645446608083 -1.90619136163798 37 1 0.032258064516129 31 7161 5578 PRKCA M00677 Wnt signaling 0.152350105669781 -1.88157407995184 38 1 0.032258064516129 31 7161 2932 GSK3B hsa_M00677 Wnt signaling 0.152350105669781 -1.88157407995184 38 1 0.032258064516129 31 7161 2932 GSK3B ko04621 NOD-like receptor signaling pathway 0.16547772064535 -1.798918711684 169 2 0.0645161290322581 31 7161 23236,3708 PLCB1,ITPR1 hsa04621 NOD-like receptor signaling pathway 0.16547772064535 -1.798918711684 169 2 0.0645161290322581 31 7161 23236,3708 PLCB1,ITPR1 ko05164 Influenza A 0.170098170545907 -1.77137953480626 172 2 0.0645161290322581 31 7161 5578,2932 PRKCA,GSK3B hsa05164 Influenza A 0.170098170545907 -1.77137953480626 172 2 0.0645161290322581 31 7161 2932,5578 GSK3B,PRKCA ko04962 Vasopressin-regulated water reabsorption 0.174252613157475 -1.74724923285438 44 1 0.032258064516129 31 7161 5567 PRKACB hsa04962 Vasopressin-regulated water reabsorption 0.174252613157475 -1.74724923285438 44 1 0.032258064516129 31 7161 5567 PRKACB hsa00565 Ether lipid metabolism 0.177849377105001 -1.72681828295534 45 1 0.032258064516129 31 7161 23646 PLD3 ko00565 Ether lipid metabolism 0.177849377105001 -1.72681828295534 45 1 0.032258064516129 31 7161 23646 PLD3 ko05202 Transcriptional misregulation in cancer 0.180967375037297 -1.70943851237573 179 2 0.0645161290322581 31 7161 2892,6256 GRIA3,RXRA hsa05202 Transcriptional misregulation in cancer 0.180967375037297 -1.70943851237573 179 2 0.0645161290322581 31 7161 6256,2892 RXRA,GRIA3 ko04930 Type II diabetes mellitus 0.181430977626516 -1.70687998616441 46 1 0.032258064516129 31 7161 774 CACNA1B hsa04930 Type II diabetes mellitus 0.181430977626516 -1.70687998616441 46 1 0.032258064516129 31 7161 774 CACNA1B ko04151 PI3K-Akt signaling pathway 0.181602784398159 -1.70593348034351 341 3 0.0967741935483871 31 7161 2932,5578,6256 GSK3B,PRKCA,RXRA hsa04151 PI3K-Akt signaling pathway 0.181602784398159 -1.70593348034351 341 3 0.0967741935483871 31 7161 6256,5578,2932 RXRA,PRKCA,GSK3B ko00520 Amino sugar and nucleotide sugar metabolism 0.188548935370264 -1.6683977016991 48 1 0.032258064516129 31 7161 80896 NPL hsa00520 Amino sugar and nucleotide sugar metabolism 0.188548935370264 -1.6683977016991 48 1 0.032258064516129 31 7161 80896 NPL hsa05016 Huntington's disease 0.193523359455931 -1.64235705309597 187 2 0.0645161290322581 31 7161 3708,23236 ITPR1,PLCB1 ko05016 Huntington's disease 0.193523359455931 -1.64235705309597 187 2 0.0645161290322581 31 7161 23236,3708 PLCB1,ITPR1 ko05213 Endometrial cancer 0.195606977924545 -1.63164784755687 50 1 0.032258064516129 31 7161 2932 GSK3B hsa05213 Endometrial cancer 0.195606977924545 -1.63164784755687 50 1 0.032258064516129 31 7161 2932 GSK3B hsa05169 Epstein-Barr virus infection 0.212576853186369 -1.54845169394812 199 2 0.0645161290322581 31 7161 2932,5567 GSK3B,PRKACB ko05169 Epstein-Barr virus infection 0.212576853186369 -1.54845169394812 199 2 0.0645161290322581 31 7161 2932,5567 GSK3B,PRKACB hsa05217 Basal cell carcinoma 0.2129931461755 -1.54649529137023 55 1 0.032258064516129 31 7161 2932 GSK3B ko05130 Pathogenic Escherichia coli infection 0.2129931461755 -1.54649529137023 55 1 0.032258064516129 31 7161 5578 PRKCA hsa05130 Pathogenic Escherichia coli infection 0.2129931461755 -1.54649529137023 55 1 0.032258064516129 31 7161 5578 PRKCA ko05217 Basal cell carcinoma 0.2129931461755 -1.54649529137023 55 1 0.032258064516129 31 7161 2932 GSK3B hsa04370 VEGF signaling pathway 0.226639704679298 -1.48439372649947 59 1 0.032258064516129 31 7161 5578 PRKCA ko04370 VEGF signaling pathway 0.226639704679298 -1.48439372649947 59 1 0.032258064516129 31 7161 5578 PRKCA ko05210 Colorectal cancer 0.230015397323014 -1.46960902741698 60 1 0.032258064516129 31 7161 2932 GSK3B hsa05210 Colorectal cancer 0.230015397323014 -1.46960902741698 60 1 0.032258064516129 31 7161 2932 GSK3B hsa04137 Mitophagy - animal 0.243376134447531 -1.41314715398567 64 1 0.032258064516129 31 7161 22808 MRAS ko04137 Mitophagy - animal 0.243376134447531 -1.41314715398567 64 1 0.032258064516129 31 7161 22808 MRAS hsa04664 Fc epsilon RI signaling pathway 0.253249170377617 -1.37338141176151 67 1 0.032258064516129 31 7161 5578 PRKCA ko04664 Fc epsilon RI signaling pathway 0.253249170377617 -1.37338141176151 67 1 0.032258064516129 31 7161 5578 PRKCA ko04920 Adipocytokine signaling pathway 0.259761806561172 -1.34799019647978 69 1 0.032258064516129 31 7161 6256 RXRA hsa04920 Adipocytokine signaling pathway 0.259761806561172 -1.34799019647978 69 1 0.032258064516129 31 7161 6256 RXRA hsa04917 Prolactin signaling pathway 0.262997478298385 -1.33561083506941 70 1 0.032258064516129 31 7161 2932 GSK3B hsa04662 B cell receptor signaling pathway 0.262997478298385 -1.33561083506941 70 1 0.032258064516129 31 7161 2932 GSK3B ko04662 B cell receptor signaling pathway 0.262997478298385 -1.33561083506941 70 1 0.032258064516129 31 7161 2932 GSK3B ko04917 Prolactin signaling pathway 0.262997478298385 -1.33561083506941 70 1 0.032258064516129 31 7161 2932 GSK3B hsa05220 Chronic myeloid leukemia 0.266219460837063 -1.32343426961863 71 1 0.032258064516129 31 7161 867 CBL ko05220 Chronic myeloid leukemia 0.266219460837063 -1.32343426961863 71 1 0.032258064516129 31 7161 867 CBL hsa03320 PPAR signaling pathway 0.269427810161253 -1.3114547903365 72 1 0.032258064516129 31 7161 6256 RXRA ko03320 PPAR signaling pathway 0.269427810161253 -1.3114547903365 72 1 0.032258064516129 31 7161 6256 RXRA ko05100 Bacterial invasion of epithelial cells 0.282125987462107 -1.26540154376334 76 1 0.032258064516129 31 7161 867 CBL hsa05100 Bacterial invasion of epithelial cells 0.282125987462107 -1.26540154376334 76 1 0.032258064516129 31 7161 867 CBL ko05222 Small cell lung cancer 0.306884693398221 -1.18128319348385 84 1 0.032258064516129 31 7161 6256 RXRA hsa05222 Small cell lung cancer 0.306884693398221 -1.18128319348385 84 1 0.032258064516129 31 7161 6256 RXRA hsa05215 Prostate cancer 0.315954469876738 -1.15215715844468 87 1 0.032258064516129 31 7161 2932 GSK3B ko05215 Prostate cancer 0.315954469876738 -1.15215715844468 87 1 0.032258064516129 31 7161 2932 GSK3B ko04666 Fc gamma R-mediated phagocytosis 0.324909343497779 -1.12420907864802 90 1 0.032258064516129 31 7161 5578 PRKCA hsa04666 Fc gamma R-mediated phagocytosis 0.324909343497779 -1.12420907864802 90 1 0.032258064516129 31 7161 5578 PRKCA ko04657 IL-17 signaling pathway 0.333750722030767 -1.09736090588195 93 1 0.032258064516129 31 7161 2932 GSK3B hsa04657 IL-17 signaling pathway 0.333750722030767 -1.09736090588195 93 1 0.032258064516129 31 7161 2932 GSK3B hsa00564 Glycerophospholipid metabolism 0.339582609189463 -1.08003803554566 95 1 0.032258064516129 31 7161 23646 PLD3 ko00564 Glycerophospholipid metabolism 0.339582609189463 -1.08003803554566 95 1 0.032258064516129 31 7161 23646 PLD3 hsa05231 Choline metabolism in cancer 0.351098541693267 -1.04668834935307 99 1 0.032258064516129 31 7161 5578 PRKCA ko05231 Choline metabolism in cancer 0.351098541693267 -1.04668834935307 99 1 0.032258064516129 31 7161 5578 PRKCA ko05142 Chagas disease (American trypanosomiasis) 0.359607715785726 -1.02274152003609 102 1 0.032258064516129 31 7161 23236 PLCB1 hsa05142 Chagas disease (American trypanosomiasis) 0.359607715785726 -1.02274152003609 102 1 0.032258064516129 31 7161 23236 PLCB1 ko04659 Th17 cell differentiation 0.3735502642263 -0.984702707222069 107 1 0.032258064516129 31 7161 6256 RXRA hsa04659 Th17 cell differentiation 0.3735502642263 -0.984702707222069 107 1 0.032258064516129 31 7161 6256 RXRA hsa04931 Insulin resistance 0.3735502642263 -0.984702707222069 107 1 0.032258064516129 31 7161 2932 GSK3B hsa04670 Leukocyte transendothelial migration 0.392577308998101 -0.935021795554595 114 1 0.032258064516129 31 7161 5578 PRKCA ko04670 Leukocyte transendothelial migration 0.392577308998101 -0.935021795554595 114 1 0.032258064516129 31 7161 5578 PRKCA ko04110 Cell cycle 0.418791662852266 -0.870381707413454 124 1 0.032258064516129 31 7161 2932 GSK3B hsa04110 Cell cycle 0.418791662852266 -0.870381707413454 124 1 0.032258064516129 31 7161 2932 GSK3B ko04650 Natural killer cell mediated cytotoxicity 0.438971609030596 -0.823320539910366 132 1 0.032258064516129 31 7161 5578 PRKCA hsa04650 Natural killer cell mediated cytotoxicity 0.438971609030596 -0.823320539910366 132 1 0.032258064516129 31 7161 5578 PRKCA ko05162 Measles 0.441445912649052 -0.817699774599028 133 1 0.032258064516129 31 7161 2932 GSK3B hsa05162 Measles 0.441445912649052 -0.817699774599028 133 1 0.032258064516129 31 7161 2932 GSK3B ko04120 Ubiquitin mediated proteolysis 0.451237943028086 -0.795760488743341 137 1 0.032258064516129 31 7161 867 CBL hsa04120 Ubiquitin mediated proteolysis 0.451237943028086 -0.795760488743341 137 1 0.032258064516129 31 7161 867 CBL ko04210 Apoptosis 0.453659871237396 -0.790407544014574 138 1 0.032258064516129 31 7161 3708 ITPR1 hsa04210 Apoptosis 0.453659871237396 -0.790407544014574 138 1 0.032258064516129 31 7161 3708 ITPR1 hsa04550 Signaling pathways regulating pluripotency of stem cells 0.45607145374582 -0.785105784932405 139 1 0.032258064516129 31 7161 2932 GSK3B ko04550 Signaling pathways regulating pluripotency of stem cells 0.45607145374582 -0.785105784932405 139 1 0.032258064516129 31 7161 2932 GSK3B ko05224 Breast cancer 0.467975670295493 -0.759338970963929 144 1 0.032258064516129 31 7161 2932 GSK3B hsa05161 Hepatitis B 0.467975670295493 -0.759338970963929 144 1 0.032258064516129 31 7161 5578 PRKCA hsa05224 Breast cancer 0.467975670295493 -0.759338970963929 144 1 0.032258064516129 31 7161 2932 GSK3B ko04390 Hippo signaling pathway 0.491032360017262 -0.711245247010543 154 1 0.032258064516129 31 7161 2932 GSK3B hsa04390 Hippo signaling pathway 0.491032360017262 -0.711245247010543 154 1 0.032258064516129 31 7161 2932 GSK3B hsa04530 Tight junction 0.52592534076864 -0.642596014020742 170 1 0.032258064516129 31 7161 5567 PRKACB ko04530 Tight junction 0.52592534076864 -0.642596014020742 170 1 0.032258064516129 31 7161 5567 PRKACB ko05152 Tuberculosis 0.542492215007878 -0.611581543886381 178 1 0.032258064516129 31 7161 817 CAMK2D hsa05152 Tuberculosis 0.542492215007878 -0.611581543886381 178 1 0.032258064516129 31 7161 817 CAMK2D ko05034 Alcoholism 0.54654556497245 -0.604137598862263 180 1 0.032258064516129 31 7161 6571 SLC18A2 hsa05034 Alcoholism 0.54654556497245 -0.604137598862263 180 1 0.032258064516129 31 7161 6571 SLC18A2 hsa05203 Viral carcinogenesis 0.587061129847856 -0.532626325142008 201 1 0.032258064516129 31 7161 5567 PRKACB ko05203 Viral carcinogenesis 0.587061129847856 -0.532626325142008 201 1 0.032258064516129 31 7161 5567 PRKACB ko04810 Regulation of actin cytoskeleton 0.60510065959209 -0.502360455299771 211 1 0.032258064516129 31 7161 22808 MRAS hsa04810 Regulation of actin cytoskeleton 0.60510065959209 -0.502360455299771 211 1 0.032258064516129 31 7161 22808 MRAS hsa04144 Endocytosis 0.68302618263065 -0.381222085401375 260 1 0.032258064516129 31 7161 867 CBL ko04144 Endocytosis 0.68302618263065 -0.381222085401375 260 1 0.032258064516129 31 7161 867 CBL hsa04080 Neuroactive ligand-receptor interaction 0.705079734223756 -0.349444384375261 276 1 0.032258064516129 31 7161 2892 GRIA3 ko04080 Neuroactive ligand-receptor interaction 0.705079734223756 -0.349444384375261 276 1 0.032258064516129 31 7161 2892 GRIA3 ko05206 MicroRNAs in cancer 0.734199462478844 -0.308974540037835 299 1 0.032258064516129 31 7161 5578 PRKCA hsa05206 MicroRNAs in cancer 0.734199462478844 -0.308974540037835 299 1 0.032258064516129 31 7161 5578 PRKCA hsa01100 Metabolic pathways 0.927904627747812 -0.0748263233008006 1256 3 0.0967741935483871 31 7161 23236,23646,51196 PLCB1,PLD3,PLCE1 ko04622 RIG-I-like receptor signaling pathway 0.999999999976128 -2.38721899186086e-11 70 0 0 31 7161 hsa04622 RIG-I-like receptor signaling pathway 0.999999999976128 -2.38721899186086e-11 70 0 0 31 7161 ko00280 Valine, leucine and isoleucine degradation 0.999999999976617 -2.33832593833594e-11 48 0 0 31 7161 hsa04330 Notch signaling pathway 0.999999999976617 -2.33832593833594e-11 48 0 0 31 7161 hsa01212 Fatty acid metabolism 0.999999999976617 -2.33832593833594e-11 48 0 0 31 7161 ko01212 Fatty acid metabolism 0.999999999976617 -2.33832593833594e-11 48 0 0 31 7161 ko04330 Notch signaling pathway 0.999999999976617 -2.33832593833594e-11 48 0 0 31 7161 hsa00280 Valine, leucine and isoleucine degradation 0.999999999976617 -2.33832593833594e-11 48 0 0 31 7161 M00359 Aminoacyl-tRNA biosynthesis, eukaryotes 0.999999999977534 -2.24664401938843e-11 38 0 0 31 7161 hsa_M00359 Aminoacyl-tRNA biosynthesis, eukaryotes 0.999999999977534 -2.24664401938843e-11 38 0 0 31 7161 hsa_M00340 Proteasome, 20S core particle 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 hsa00790 Folate biosynthesis 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 ko00730 Thiamine metabolism 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 M00158 F-type ATPase, eukaryotes 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 ko00604 Glycosphingolipid biosynthesis - ganglio series 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 M00340 Proteasome, 20S core particle 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 hsa_M00686 Toll-like receptor signaling 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 hsa00604 Glycosphingolipid biosynthesis - ganglio series 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 hsa_M00146 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 hsa00730 Thiamine metabolism 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 hsa_M00158 F-type ATPase, eukaryotes 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 ko00790 Folate biosynthesis 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 M00146 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 M00686 Toll-like receptor signaling 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 0.999999999977846 -2.2154249136941e-11 15 0 0 31 7161 ko04672 Intestinal immune network for IgA production 0.999999999977909 -2.20909477552026e-11 47 0 0 31 7161 hsa00600 Sphingolipid metabolism 0.999999999977909 -2.20909477552026e-11 47 0 0 31 7161 hsa04672 Intestinal immune network for IgA production 0.999999999977909 -2.20909477552026e-11 47 0 0 31 7161 ko03420 Nucleotide excision repair 0.999999999977909 -2.20909477552026e-11 47 0 0 31 7161 hsa03420 Nucleotide excision repair 0.999999999977909 -2.20909477552026e-11 47 0 0 31 7161 ko00600 Sphingolipid metabolism 0.999999999977909 -2.20909477552026e-11 47 0 0 31 7161 M00066 Lactosylceramide biosynthesis 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00294 DNA polymerase gamma complex 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00293 DNA polymerase zeta complex 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00103 Cholecalciferol biosynthesis 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00068 Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00399 Cap binding complex 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00083 Fatty acid biosynthesis, elongation 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00338 Cysteine biosynthesis, homocysteine + serine => cysteine 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00067 Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 ko00300 Lysine biosynthesis 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00294 DNA polymerase gamma complex 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00338 Cysteine biosynthesis, homocysteine + serine => cysteine 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00066 Lactosylceramide biosynthesis 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00103 Cholecalciferol biosynthesis 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00293 DNA polymerase zeta complex 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00068 Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa00300 Lysine biosynthesis 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00151 Cytochrome bc1 complex respiratory unit 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00106 Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00083 Fatty acid biosynthesis, elongation 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00399 Cap binding complex 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00106 Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa_M00151 Cytochrome bc1 complex respiratory unit 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 M00067 Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid 0.999999999978977 -2.10224863572369e-11 2 0 0 31 7161 hsa04620 Toll-like receptor signaling pathway 0.999999999979382 -2.06183036704779e-11 104 0 0 31 7161 ko00240 Pyrimidine metabolism 0.999999999979382 -2.06183036704779e-11 104 0 0 31 7161 ko04620 Toll-like receptor signaling pathway 0.999999999979382 -2.06183036704779e-11 104 0 0 31 7161 hsa00240 Pyrimidine metabolism 0.999999999979382 -2.06183036704779e-11 104 0 0 31 7161 hsa04350 TGF-beta signaling pathway 0.99999999997997 -2.00300666121778e-11 84 0 0 31 7161 ko04350 TGF-beta signaling pathway 0.99999999997997 -2.00300666121778e-11 84 0 0 31 7161 hsa01523 Antifolate resistance 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 hsa00052 Galactose metabolism 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 ko04710 Circadian rhythm 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 hsa00410 beta-Alanine metabolism 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 hsa00512 Mucin type O-glycan biosynthesis 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 ko00410 beta-Alanine metabolism 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 ko00052 Galactose metabolism 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 hsa04710 Circadian rhythm 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 ko01523 Antifolate resistance 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 ko03020 RNA polymerase 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 ko00512 Mucin type O-glycan biosynthesis 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 hsa03020 RNA polymerase 0.99999999998075 -1.92503127552991e-11 31 0 0 31 7161 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 M00056 O-glycan biosynthesis, mucin type core 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 ko04966 Collecting duct acid secretion 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 M00014 Glucuronate pathway (uronate pathway) 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 hsa_M00014 Glucuronate pathway (uronate pathway) 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 hsa00053 Ascorbate and aldarate metabolism 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 hsa04966 Collecting duct acid secretion 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 ko00053 Ascorbate and aldarate metabolism 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 hsa_M00056 O-glycan biosynthesis, mucin type core 0.999999999980844 -1.91561802694618e-11 27 0 0 31 7161 ko00860 Porphyrin and chlorophyll metabolism 0.999999999981106 -1.88939858500699e-11 42 0 0 31 7161 hsa00860 Porphyrin and chlorophyll metabolism 0.999999999981106 -1.88939858500699e-11 42 0 0 31 7161 M00683 Hippo signaling 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 M00075 N-glycan biosynthesis, complex type 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 hsa_M00683 Hippo signaling 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 hsa_M00075 N-glycan biosynthesis, complex type 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 M00099 Sphingosine biosynthesis 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 M00295 BRCA1-associated genome surveillance complex (BASC) 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 hsa_M00099 Sphingosine biosynthesis 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 hsa_M00682 Notch signaling 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 M00682 Notch signaling 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 hsa_M00295 BRCA1-associated genome surveillance complex (BASC) 0.999999999981627 -1.83734299247745e-11 16 0 0 31 7161 M00055 N-glycan precursor biosynthesis 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 hsa_M00147 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 hsa_M00055 N-glycan precursor biosynthesis 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 M00147 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 hsa_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 M00389 APC/C complex 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 hsa_M00353 Spliceosome, Prp19/CDC5L complex 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 ko00533 Glycosaminoglycan biosynthesis - keratan sulfate 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 hsa_M00389 APC/C complex 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 M00353 Spliceosome, Prp19/CDC5L complex 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 hsa_M00180 RNA polymerase II, eukaryotes 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 M00180 RNA polymerase II, eukaryotes 0.999999999981783 -1.82173755520508e-11 14 0 0 31 7161 ko04940 Type I diabetes mellitus 0.999999999981823 -1.81768772340225e-11 43 0 0 31 7161 hsa04940 Type I diabetes mellitus 0.999999999981823 -1.81768772340225e-11 43 0 0 31 7161 hsa00250 Alanine, aspartate and glutamate metabolism 0.999999999981928 -1.80716783527545e-11 35 0 0 31 7161 ko00250 Alanine, aspartate and glutamate metabolism 0.999999999981928 -1.80716783527545e-11 35 0 0 31 7161 hsa00350 Tyrosine metabolism 0.999999999981928 -1.80716783527545e-11 35 0 0 31 7161 ko00350 Tyrosine metabolism 0.999999999981928 -1.80716783527545e-11 35 0 0 31 7161 ko00480 Glutathione metabolism 0.999999999982169 -1.78306665494251e-11 54 0 0 31 7161 hsa00480 Glutathione metabolism 0.999999999982169 -1.78306665494251e-11 54 0 0 31 7161 ko03460 Fanconi anemia pathway 0.999999999982169 -1.78306665494251e-11 54 0 0 31 7161 hsa03460 Fanconi anemia pathway 0.999999999982169 -1.78306665494251e-11 54 0 0 31 7161 ko05014 Amyotrophic lateral sclerosis (ALS) 0.999999999983353 -1.66471294889665e-11 51 0 0 31 7161 hsa04978 Mineral absorption 0.999999999983353 -1.66471294889665e-11 51 0 0 31 7161 ko04978 Mineral absorption 0.999999999983353 -1.66471294889665e-11 51 0 0 31 7161 hsa05014 Amyotrophic lateral sclerosis (ALS) 0.999999999983353 -1.66471294889665e-11 51 0 0 31 7161 hsa04614 Renin-angiotensin system 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 hsa03060 Protein export 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 ko00515 Mannose type O-glycan biosynthesis 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 ko04614 Renin-angiotensin system 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 hsa03430 Mismatch repair 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 hsa00515 Mannose type O-glycan biosynthesis 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 ko03060 Protein export 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 ko04964 Proximal tubule bicarbonate reclamation 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 hsa04964 Proximal tubule bicarbonate reclamation 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 ko01040 Biosynthesis of unsaturated fatty acids 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 ko03430 Mismatch repair 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 hsa01040 Biosynthesis of unsaturated fatty acids 0.999999999983397 -1.66032312199805e-11 23 0 0 31 7161 hsa04950 Maturity onset diabetes of the young 0.999999999983486 -1.6514421150594e-11 26 0 0 31 7161 ko04950 Maturity onset diabetes of the young 0.999999999983486 -1.6514421150594e-11 26 0 0 31 7161 hsa05221 Acute myeloid leukemia 0.999999999983502 -1.64983294250078e-11 55 0 0 31 7161 hsa05134 Legionellosis 0.999999999983502 -1.64983294250078e-11 55 0 0 31 7161 ko05150 Staphylococcus aureus infection 0.999999999983502 -1.64983294250078e-11 55 0 0 31 7161 ko05134 Legionellosis 0.999999999983502 -1.64983294250078e-11 55 0 0 31 7161 ko05221 Acute myeloid leukemia 0.999999999983502 -1.64983294250078e-11 55 0 0 31 7161 hsa05150 Staphylococcus aureus infection 0.999999999983502 -1.64983294250078e-11 55 0 0 31 7161 M00050 Guanine ribonucleotide biosynthesis IMP => GDP,GTP 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 M00403 HRD1/SEL1 ERAD complex 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 ko00061 Fatty acid biosynthesis 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 M00676 PI3K-Akt signaling 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa00061 Fatty acid biosynthesis 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa_M00676 PI3K-Akt signaling 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa_M00692 Cell cycle - G1/S transition 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 M00692 Cell cycle - G1/S transition 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa_M00403 HRD1/SEL1 ERAD complex 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa_M00050 Guanine ribonucleotide biosynthesis IMP => GDP,GTP 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa03450 Non-homologous end-joining 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 ko03450 Non-homologous end-joining 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 hsa_M00036 Leucine degradation, leucine => acetoacetate + acetyl-CoA 0.999999999983965 -1.6034629983748e-11 13 0 0 31 7161 ko05140 Leishmaniasis 0.999999999984101 -1.5899034429875e-11 72 0 0 31 7161 ko04520 Adherens junction 0.999999999984101 -1.5899034429875e-11 72 0 0 31 7161 hsa04520 Adherens junction 0.999999999984101 -1.5899034429875e-11 72 0 0 31 7161 hsa05140 Leishmaniasis 0.999999999984101 -1.5899034429875e-11 72 0 0 31 7161 hsa_M00430 Exon junction complex (EJC) 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 hsa00511 Other glycan degradation 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 hsa00770 Pantothenate and CoA biosynthesis 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 M00430 Exon junction complex (EJC) 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 ko01210 2-Oxocarboxylic acid metabolism 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 ko00511 Other glycan degradation 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 hsa01210 2-Oxocarboxylic acid metabolism 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 ko00770 Pantothenate and CoA biosynthesis 0.999999999984382 -1.56184262197405e-11 18 0 0 31 7161 hsa_M00354 Spliceosome, U4/U6.U5 tri-snRNP 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 M00354 Spliceosome, U4/U6.U5 tri-snRNP 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 hsa00030 Pentose phosphate pathway 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 ko05310 Asthma 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 ko00020 Citrate cycle (TCA cycle) 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 hsa05310 Asthma 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 hsa00020 Citrate cycle (TCA cycle) 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 ko00030 Pentose phosphate pathway 0.99999999998475 -1.52504482590402e-11 30 0 0 31 7161 ko05320 Autoimmune thyroid disease 0.999999999984988 -1.5011511500596e-11 52 0 0 31 7161 hsa05320 Autoimmune thyroid disease 0.999999999984988 -1.5011511500596e-11 52 0 0 31 7161 ko04320 Dorso-ventral axis formation 0.999999999985048 -1.4951540268106e-11 28 0 0 31 7161 ko00630 Glyoxylate and dicarboxylate metabolism 0.999999999985048 -1.4951540268106e-11 28 0 0 31 7161 hsa00630 Glyoxylate and dicarboxylate metabolism 0.999999999985048 -1.4951540268106e-11 28 0 0 31 7161 hsa00650 Butanoate metabolism 0.999999999985048 -1.4951540268106e-11 28 0 0 31 7161 ko00650 Butanoate metabolism 0.999999999985048 -1.4951540268106e-11 28 0 0 31 7161 hsa04320 Dorso-ventral axis formation 0.999999999985048 -1.4951540268106e-11 28 0 0 31 7161 hsa05145 Toxoplasmosis 0.999999999985139 -1.48605772028456e-11 113 0 0 31 7161 ko05145 Toxoplasmosis 0.999999999985139 -1.48605772028456e-11 113 0 0 31 7161 hsa04216 Ferroptosis 0.999999999985301 -1.46987197415594e-11 40 0 0 31 7161 ko00380 Tryptophan metabolism 0.999999999985301 -1.46987197415594e-11 40 0 0 31 7161 hsa00380 Tryptophan metabolism 0.999999999985301 -1.46987197415594e-11 40 0 0 31 7161 ko04216 Ferroptosis 0.999999999985301 -1.46987197415594e-11 40 0 0 31 7161 ko04130 SNARE interactions in vesicular transport 0.999999999985308 -1.46922453299946e-11 34 0 0 31 7161 hsa04130 SNARE interactions in vesicular transport 0.999999999985308 -1.46922453299946e-11 34 0 0 31 7161 ko00040 Pentose and glucuronate interconversions 0.999999999985308 -1.46922453299946e-11 34 0 0 31 7161 hsa00040 Pentose and glucuronate interconversions 0.999999999985308 -1.46922453299946e-11 34 0 0 31 7161 ko05133 Pertussis 0.999999999985457 -1.45428604831247e-11 76 0 0 31 7161 hsa05133 Pertussis 0.999999999985457 -1.45428604831247e-11 76 0 0 31 7161 M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 M00078 Heparan sulfate degradation 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 hsa_M00076 Dermatan sulfate degradation 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 M00361 Nucleotide sugar biosynthesis, eukaryotes 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 M00076 Dermatan sulfate degradation 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 hsa_M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 hsa_M00078 Heparan sulfate degradation 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 hsa_M00361 Nucleotide sugar biosynthesis, eukaryotes 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 hsa_M00135 GABA biosynthesis, eukaryotes, putrescine => GABA 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 M00135 GABA biosynthesis, eukaryotes, putrescine => GABA 0.999999999985491 -1.45086001922315e-11 9 0 0 31 7161 hsa00010 Glycolysis / Gluconeogenesis 0.999999999985654 -1.43463467791228e-11 67 0 0 31 7161 ko00010 Glycolysis / Gluconeogenesis 0.999999999985654 -1.43463467791228e-11 67 0 0 31 7161 ko03030 DNA replication 0.999999999985888 -1.41124360090055e-11 36 0 0 31 7161 ko05340 Primary immunodeficiency 0.999999999985888 -1.41124360090055e-11 36 0 0 31 7161 hsa03030 DNA replication 0.999999999985888 -1.41124360090055e-11 36 0 0 31 7161 ko00500 Starch and sucrose metabolism 0.999999999985888 -1.41124360090055e-11 36 0 0 31 7161 hsa00500 Starch and sucrose metabolism 0.999999999985888 -1.41124360090055e-11 36 0 0 31 7161 hsa05340 Primary immunodeficiency 0.999999999985888 -1.41124360090055e-11 36 0 0 31 7161 ko00531 Glycosaminoglycan degradation 0.999999999986037 -1.39631519708943e-11 19 0 0 31 7161 hsa00531 Glycosaminoglycan degradation 0.999999999986037 -1.39631519708943e-11 19 0 0 31 7161 M00684 JAK-STAT signaling 0.999999999986037 -1.39631519708943e-11 19 0 0 31 7161 hsa_M00341 Proteasome, 19S regulatory particle (PA700) 0.999999999986037 -1.39631519708943e-11 19 0 0 31 7161 hsa_M00684 JAK-STAT signaling 0.999999999986037 -1.39631519708943e-11 19 0 0 31 7161 M00341 Proteasome, 19S regulatory particle (PA700) 0.999999999986037 -1.39631519708943e-11 19 0 0 31 7161 hsa05322 Systemic lupus erythematosus 0.999999999986125 -1.38748207371758e-11 132 0 0 31 7161 ko05322 Systemic lupus erythematosus 0.999999999986125 -1.38748207371758e-11 132 0 0 31 7161 hsa03040 Spliceosome 0.999999999986125 -1.38748207371758e-11 132 0 0 31 7161 ko03040 Spliceosome 0.999999999986125 -1.38748207371758e-11 132 0 0 31 7161 hsa04068 FoxO signaling pathway 0.999999999986125 -1.38748207371758e-11 132 0 0 31 7161 hsa04623 Cytosolic DNA-sensing pathway 0.999999999986166 -1.38336425489186e-11 63 0 0 31 7161 ko04623 Cytosolic DNA-sensing pathway 0.999999999986166 -1.38336425489186e-11 63 0 0 31 7161 hsa05230 Central carbon metabolism in cancer 0.999999999986196 -1.38043777309012e-11 65 0 0 31 7161 ko05321 Inflammatory bowel disease (IBD) 0.999999999986196 -1.38043777309012e-11 65 0 0 31 7161 hsa00830 Retinol metabolism 0.999999999986196 -1.38043777309012e-11 65 0 0 31 7161 ko05230 Central carbon metabolism in cancer 0.999999999986196 -1.38043777309012e-11 65 0 0 31 7161 hsa05321 Inflammatory bowel disease (IBD) 0.999999999986196 -1.38043777309012e-11 65 0 0 31 7161 ko00830 Retinol metabolism 0.999999999986196 -1.38043777309012e-11 65 0 0 31 7161 M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 hsa00592 alpha-Linolenic acid metabolism 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 hsa_M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 hsa00062 Fatty acid elongation 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 ko00062 Fatty acid elongation 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 ko00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 ko00592 alpha-Linolenic acid metabolism 0.999999999986224 -1.37764015145545e-11 25 0 0 31 7161 hsa00260 Glycine, serine and threonine metabolism 0.999999999986263 -1.37366462190385e-11 39 0 0 31 7161 ko00620 Pyruvate metabolism 0.999999999986263 -1.37366462190385e-11 39 0 0 31 7161 hsa00620 Pyruvate metabolism 0.999999999986263 -1.37366462190385e-11 39 0 0 31 7161 ko00260 Glycine, serine and threonine metabolism 0.999999999986263 -1.37366462190385e-11 39 0 0 31 7161 hsa04658 Th1 and Th2 cell differentiation 0.99999999998629 -1.37101225769915e-11 92 0 0 31 7161 ko04658 Th1 and Th2 cell differentiation 0.99999999998629 -1.37101225769915e-11 92 0 0 31 7161 hsa00640 Propanoate metabolism 0.99999999998631 -1.36905149272261e-11 32 0 0 31 7161 ko00640 Propanoate metabolism 0.99999999998631 -1.36905149272261e-11 32 0 0 31 7161 ko04136 Autophagy - other 0.99999999998631 -1.36905149272261e-11 32 0 0 31 7161 hsa04136 Autophagy - other 0.99999999998631 -1.36905149272261e-11 32 0 0 31 7161 ko05219 Bladder cancer 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 hsa05332 Graft-versus-host disease 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 hsa04975 Fat digestion and absorption 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 ko03440 Homologous recombination 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 ko04975 Fat digestion and absorption 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 hsa05219 Bladder cancer 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 ko05332 Graft-versus-host disease 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 hsa03440 Homologous recombination 0.999999999986437 -1.35633940759231e-11 41 0 0 31 7161 hsa_M00071 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00289 RF-C complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00385 Cul4-DDB1-DDB2 complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa00400 Phenylalanine, tyrosine and tryptophan biosynthesis 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00042 Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00405 THC complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 ko00524 Neomycin, kanamycin and gentamicin biosynthesis 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00382 SCF-FBS complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa00232 Caffeine metabolism 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00128 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00414 Bloom's syndrome complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00037 Melatonin biosynthesis, tryptophan => serotonin => melatonin 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 ko00400 Phenylalanine, tyrosine and tryptophan biosynthesis 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00042 Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 ko00232 Caffeine metabolism 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00044 Tyrosine degradation, tyrosine => homogentisate 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00414 Bloom's syndrome complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa00524 Neomycin, kanamycin and gentamicin biosynthesis 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00380 SCF-BTRC complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00386 Cul4-DDB1-CSA complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00044 Tyrosine degradation, tyrosine => homogentisate 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00079 Keratan sulfate degradation 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00380 SCF-BTRC complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00386 Cul4-DDB1-CSA complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00289 RF-C complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00385 Cul4-DDB1-DDB2 complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00382 SCF-FBS complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00057 Glycosaminoglycan biosynthesis, linkage tetrasaccharide 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00057 Glycosaminoglycan biosynthesis, linkage tetrasaccharide 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00405 THC complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00037 Melatonin biosynthesis, tryptophan => serotonin => melatonin 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00383 ECV complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00383 ECV complex 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa_M00079 Keratan sulfate degradation 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00071 Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00307 Pyruvate oxidation, pyruvate => acetyl-CoA 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 M00128 Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone 0.999999999986729 -1.32711298441941e-11 5 0 0 31 7161 hsa04380 Osteoclast differentiation 0.999999999987039 -1.29614265654407e-11 129 0 0 31 7161 ko04380 Osteoclast differentiation 0.999999999987039 -1.29614265654407e-11 129 0 0 31 7161 hsa00051 Fructose and mannose metabolism 0.999999999987107 -1.28925671518689e-11 33 0 0 31 7161 hsa03410 Base excision repair 0.999999999987107 -1.28925671518689e-11 33 0 0 31 7161 ko03410 Base excision repair 0.999999999987107 -1.28925671518689e-11 33 0 0 31 7161 ko00051 Fructose and mannose metabolism 0.999999999987107 -1.28925671518689e-11 33 0 0 31 7161 ko04215 Apoptosis - multiple species 0.999999999987107 -1.28925671518689e-11 33 0 0 31 7161 hsa04215 Apoptosis - multiple species 0.999999999987107 -1.28925671518689e-11 33 0 0 31 7161 M00160 V-type ATPase, eukaryotes 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 ko00340 Histidine metabolism 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 hsa00340 Histidine metabolism 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 ko00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 hsa_M00160 V-type ATPase, eukaryotes 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 ko04977 Vitamin digestion and absorption 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 hsa04977 Vitamin digestion and absorption 0.99999999998747 -1.2529528302069e-11 24 0 0 31 7161 ko00590 Arachidonic acid metabolism 0.999999999987509 -1.2491219531107e-11 62 0 0 31 7161 hsa00590 Arachidonic acid metabolism 0.999999999987509 -1.2491219531107e-11 62 0 0 31 7161 hsa05120 Epithelial cell signaling in Helicobacter pylori infection 0.999999999987739 -1.22610187040123e-11 68 0 0 31 7161 ko05120 Epithelial cell signaling in Helicobacter pylori infection 0.999999999987739 -1.22610187040123e-11 68 0 0 31 7161 ko05418 Fluid shear stress and atherosclerosis 0.999999999987863 -1.21374355524281e-11 142 0 0 31 7161 hsa05418 Fluid shear stress and atherosclerosis 0.999999999987863 -1.21374355524281e-11 142 0 0 31 7161 M00291 MRN complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00392 Ski complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00134 Polyamine biosynthesis, arginine => ornithine => putrescine 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00132 Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00297 DNA-PK complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00118 Glutathione biosynthesis, glutamate => glutathione 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00108 C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa00780 Biotin metabolism 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00051 Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00392 Ski complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00291 MRN complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00005 PRPP biosynthesis, ribose 5P => PRPP 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00020 Serine biosynthesis, glycerate-3P => serine 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00107 Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00410 ESCRT-II complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00051 Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00005 PRPP biosynthesis, ribose 5P => PRPP 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00408 ESCRT-0 complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00297 DNA-PK complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00410 ESCRT-II complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00134 Polyamine biosynthesis, arginine => ornithine => putrescine 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00100 Sphingosine degradation 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00046 Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00118 Glutathione biosynthesis, glutamate => glutathione 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00408 ESCRT-0 complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00069 Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00132 Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00100 Sphingosine degradation 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00069 Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00107 Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00400 p97-Ufd1-Npl4 complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 ko00780 Biotin metabolism 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00020 Serine biosynthesis, glycerate-3P => serine 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00400 p97-Ufd1-Npl4 complex 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 ko00785 Lipoic acid metabolism 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00082 Fatty acid biosynthesis, initiation 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa00785 Lipoic acid metabolism 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 hsa_M00108 C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00082 Fatty acid biosynthesis, initiation 0.999999999988119 -1.18815354000288e-11 3 0 0 31 7161 M00413 FA core complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00351 Spliceosome, U1-snRNP 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00095 C5 isoprenoid biosynthesis, mevalonate pathway 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00351 Spliceosome, U1-snRNP 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00152 Cytochrome bc1 complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00296 BER complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00152 Cytochrome bc1 complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 ko00920 Sulfur metabolism 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00681 Activin signaling 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00426 Survival motor neuron (SMN) complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00681 Activin signaling 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00693 Cell cycle - G2/M transition 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00095 C5 isoprenoid biosynthesis, mevalonate pathway 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00413 FA core complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00035 Methionine degradation 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa00072 Synthesis and degradation of ketone bodies 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00391 Exosome, eukaryotes 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 ko00072 Synthesis and degradation of ketone bodies 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00059 Glycosaminoglycan biosynthesis, heparan sulfate backbone 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00059 Glycosaminoglycan biosynthesis, heparan sulfate backbone 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00035 Methionine degradation 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00426 Survival motor neuron (SMN) complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00693 Cell cycle - G2/M transition 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 M00296 BER complex 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa00920 Sulfur metabolism 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa_M00391 Exosome, eukaryotes 0.999999999988305 -1.16947349591708e-11 10 0 0 31 7161 hsa04392 Hippo signaling pathway -multiple species 0.999999999988761 -1.12385125612578e-11 29 0 0 31 7161 hsa00760 Nicotinate and nicotinamide metabolism 0.999999999988761 -1.12385125612578e-11 29 0 0 31 7161 ko00760 Nicotinate and nicotinamide metabolism 0.999999999988761 -1.12385125612578e-11 29 0 0 31 7161 hsa00591 Linoleic acid metabolism 0.999999999988761 -1.12385125612578e-11 29 0 0 31 7161 ko04392 Hippo signaling pathway -multiple species 0.999999999988761 -1.12385125612578e-11 29 0 0 31 7161 ko00591 Linoleic acid metabolism 0.999999999988761 -1.12385125612578e-11 29 0 0 31 7161 hsa00472 D-Arginine and D-ornithine metabolism 0.999999999988776 -1.12244710054332e-11 1 0 0 31 7161 hsa_M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC 0.999999999988776 -1.12244710054332e-11 1 0 0 31 7161 hsa_M00043 Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine 0.999999999988776 -1.12244710054332e-11 1 0 0 31 7161 ko00472 D-Arginine and D-ornithine metabolism 0.999999999988776 -1.12244710054332e-11 1 0 0 31 7161 M00091 Phosphatidylcholine (PC) biosynthesis, PE => PC 0.999999999988776 -1.12244710054332e-11 1 0 0 31 7161 M00043 Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine 0.999999999988776 -1.12244710054332e-11 1 0 0 31 7161 hsa05330 Allograft rejection 0.999999999988883 -1.11165397420253e-11 37 0 0 31 7161 M00355 Spliceosome, 35S U5-snRNP 0.999999999988883 -1.11165397420253e-11 37 0 0 31 7161 hsa_M00355 Spliceosome, 35S U5-snRNP 0.999999999988883 -1.11165397420253e-11 37 0 0 31 7161 ko05330 Allograft rejection 0.999999999988883 -1.11165397420253e-11 37 0 0 31 7161 hsa00561 Glycerolipid metabolism 0.999999999989238 -1.07620800748379e-11 59 0 0 31 7161 ko00561 Glycerolipid metabolism 0.999999999989238 -1.07620800748379e-11 59 0 0 31 7161 hsa00310 Lysine degradation 0.999999999989238 -1.07620800748379e-11 59 0 0 31 7161 ko00310 Lysine degradation 0.999999999989238 -1.07620800748379e-11 59 0 0 31 7161 ko00190 Oxidative phosphorylation 0.999999999989389 -1.06108178369885e-11 120 0 0 31 7161 ko04152 AMPK signaling pathway 0.999999999989389 -1.06108178369885e-11 120 0 0 31 7161 hsa04152 AMPK signaling pathway 0.999999999989389 -1.06108178369885e-11 120 0 0 31 7161 hsa00190 Oxidative phosphorylation 0.999999999989389 -1.06108178369885e-11 120 0 0 31 7161 ko04974 Protein digestion and absorption 0.999999999989766 -1.02336475956252e-11 89 0 0 31 7161 ko05323 Rheumatoid arthritis 0.999999999989766 -1.02336475956252e-11 89 0 0 31 7161 hsa04974 Protein digestion and absorption 0.999999999989766 -1.02336475956252e-11 89 0 0 31 7161 hsa05323 Rheumatoid arthritis 0.999999999989766 -1.02336475956252e-11 89 0 0 31 7161 M00387 SCF-FBW7 complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00401 Sec61 complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00741 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00381 SCF-SKP2 complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00685 Apoptotic machinery 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00286 GINS complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00384 Cul3-SPOP complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00286 GINS complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00263 DNA polymerase epsilon complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00393 TRAMP complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00261 DNA polymerase alpha / primase complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00384 Cul3-SPOP complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00288 RPA complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00027 GABA (gamma-Aminobutyrate) shunt 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 ko00290 Valine, leucine and isoleucine biosynthesis 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa00290 Valine, leucine and isoleucine biosynthesis 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00387 SCF-FBW7 complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00070 Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00262 DNA polymerase delta complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00685 Apoptotic machinery 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00741 Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00390 Exosome, archaea 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00027 GABA (gamma-Aminobutyrate) shunt 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00133 Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00288 RPA complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00425 H/ACA ribonucleoprotein complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00148 Succinate dehydrogenase (ubiquinone) 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa00471 D-Glutamine and D-glutamate metabolism 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00261 DNA polymerase alpha / primase complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00425 H/ACA ribonucleoprotein complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00690 MAPK (ERK5) signaling 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00110 C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 ko00471 D-Glutamine and D-glutamate metabolism 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00401 Sec61 complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00402 Translocon-associated protein (TRAP) complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00015 Proline biosynthesis, glutamate => proline 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00393 TRAMP complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00262 DNA polymerase delta complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00381 SCF-SKP2 complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00015 Proline biosynthesis, glutamate => proline 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00402 Translocon-associated protein (TRAP) complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00263 DNA polymerase epsilon complex 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 M00390 Exosome, archaea 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00148 Succinate dehydrogenase (ubiquinone) 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00690 MAPK (ERK5) signaling 0.999999999989774 -1.022566380383e-11 4 0 0 31 7161 hsa_M00177 Ribosome, eukaryotes 0.99999999999026 -9.73959893406503e-12 91 0 0 31 7161 hsa03015 mRNA surveillance pathway 0.99999999999026 -9.73959893406503e-12 91 0 0 31 7161 M00177 Ribosome, eukaryotes 0.99999999999026 -9.73959893406503e-12 91 0 0 31 7161 ko03015 mRNA surveillance pathway 0.99999999999026 -9.73959893406503e-12 91 0 0 31 7161 hsa00900 Terpenoid backbone biosynthesis 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 hsa_M00009 Citrate cycle (TCA cycle, Krebs cycle) 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 hsa_M00689 MAPK (p38) signaling 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 hsa00514 Other types of O-glycan biosynthesis 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 ko00514 Other types of O-glycan biosynthesis 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 ko00900 Terpenoid backbone biosynthesis 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 M00009 Citrate cycle (TCA cycle, Krebs cycle) 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 M00689 MAPK (p38) signaling 0.999999999990329 -9.67078759037215e-12 22 0 0 31 7161 M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 hsa_M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 hsa_M00688 MAPK (JNK) signaling 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 ko00220 Arginine biosynthesis 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 hsa00220 Arginine biosynthesis 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 hsa_M00154 Cytochrome c oxidase 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 M00688 MAPK (JNK) signaling 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 M00154 Cytochrome c oxidase 0.999999999990469 -9.53121516999449e-12 21 0 0 31 7161 hsa00983 Drug metabolism - other enzymes 0.999999999990647 -9.35315154562966e-12 46 0 0 31 7161 ko00983 Drug metabolism - other enzymes 0.999999999990647 -9.35315154562966e-12 46 0 0 31 7161 hsa02010 ABC transporters 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 ko04973 Carbohydrate digestion and absorption 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 hsa00071 Fatty acid degradation 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 hsa00970 Aminoacyl-tRNA biosynthesis 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 ko02010 ABC transporters 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 ko00270 Cysteine and methionine metabolism 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 ko00970 Aminoacyl-tRNA biosynthesis 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 hsa00270 Cysteine and methionine metabolism 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 ko00071 Fatty acid degradation 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 hsa04973 Carbohydrate digestion and absorption 0.999999999990814 -9.18583144598322e-12 44 0 0 31 7161 M00098 Acylglycerol degradation 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa_M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa_M00098 Acylglycerol degradation 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa_M00143 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 M00678 Hedgehog signaling 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa_M00034 Methionine salvage pathway 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa00430 Taurine and hypotaurine metabolism 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa_M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 M00034 Methionine salvage pathway 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa_M00678 Hedgehog signaling 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 M00143 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa_M00404 COPII complex 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 M00404 COPII complex 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 ko00430 Taurine and hypotaurine metabolism 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 ko00130 Ubiquinone and other terpenoid-quinone biosynthesis 0.999999999990892 -9.10798844953242e-12 11 0 0 31 7161 hsa04668 TNF signaling pathway 0.999999999991125 -8.87496592500966e-12 108 0 0 31 7161 ko04668 TNF signaling pathway 0.999999999991125 -8.87496592500966e-12 108 0 0 31 7161 hsa04146 Peroxisome 0.999999999991197 -8.8027100508028e-12 83 0 0 31 7161 ko04146 Peroxisome 0.999999999991197 -8.8027100508028e-12 83 0 0 31 7161 ko00330 Arginine and proline metabolism 0.999999999991275 -8.72488684988052e-12 49 0 0 31 7161 hsa00330 Arginine and proline metabolism 0.999999999991275 -8.72488684988052e-12 49 0 0 31 7161 ko05144 Malaria 0.999999999991275 -8.72488684988052e-12 49 0 0 31 7161 ko00510 N-Glycan biosynthesis 0.999999999991275 -8.72488684988052e-12 49 0 0 31 7161 hsa00510 N-Glycan biosynthesis 0.999999999991275 -8.72488684988052e-12 49 0 0 31 7161 hsa05144 Malaria 0.999999999991275 -8.72488684988052e-12 49 0 0 31 7161 hsa00100 Steroid biosynthesis 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 hsa00670 One carbon pool by folate 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 hsa_M00352 Spliceosome, U2-snRNP 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 hsa_M00679 BMP signaling 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 ko00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 ko00100 Steroid biosynthesis 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 ko00670 One carbon pool by folate 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 M00679 BMP signaling 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 M00352 Spliceosome, U2-snRNP 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 0.999999999991841 -8.15888608414838e-12 20 0 0 31 7161 hsa_M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00549 Nucleotide sugar biosynthesis, glucose => UDP-glucose 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00047 Creatine pathway 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00691 DNA damage-induced cell cycle checkpoints 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00691 DNA damage-induced cell cycle checkpoints 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00072 N-glycosylation by oligosaccharyltransferase 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00397 Lsm 1-7 complex 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00397 Lsm 1-7 complex 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00398 Sm core complex 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00086 beta-Oxidation, acyl-CoA synthesis 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00396 Lsm 2-8 complex 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00398 Sm core complex 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00120 Coenzyme A biosynthesis, pantothenate => CoA 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00120 Coenzyme A biosynthesis, pantothenate => CoA 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00047 Creatine pathway 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00396 Lsm 2-8 complex 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00072 N-glycosylation by oligosaccharyltransferase 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 hsa_M00086 beta-Oxidation, acyl-CoA synthesis 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P 0.999999999992079 -7.92051567680902e-12 7 0 0 31 7161 ko04514 Cell adhesion molecules (CAMs) 0.999999999992137 -7.86307898179215e-12 143 0 0 31 7161 hsa04514 Cell adhesion molecules (CAMs) 0.999999999992137 -7.86307898179215e-12 143 0 0 31 7161 ko05218 Melanoma 0.999999999992251 -7.74902885968272e-12 69 0 0 31 7161 hsa04115 p53 signaling pathway 0.999999999992251 -7.74902885968272e-12 69 0 0 31 7161 ko00982 Drug metabolism - cytochrome P450 0.999999999992251 -7.74902885968272e-12 69 0 0 31 7161 hsa05218 Melanoma 0.999999999992251 -7.74902885968272e-12 69 0 0 31 7161 hsa00982 Drug metabolism - cytochrome P450 0.999999999992251 -7.74902885968272e-12 69 0 0 31 7161 ko04115 p53 signaling pathway 0.999999999992251 -7.74902885968272e-12 69 0 0 31 7161 hsa04142 Lysosome 0.999999999992472 -7.52821106854271e-12 123 0 0 31 7161 ko04142 Lysosome 0.999999999992472 -7.52821106854271e-12 123 0 0 31 7161 ko04122 Sulfur relay system 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00406 TREX complex 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 ko00740 Riboflavin metabolism 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00680 TGF-beta signaling 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00409 ESCRT-I complex 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00687 MAPK (ERK1/2) signaling 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00077 Chondroitin sulfate degradation 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00680 TGF-beta signaling 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00428 eIF4F complex 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00077 Chondroitin sulfate degradation 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa04122 Sulfur relay system 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa00740 Riboflavin metabolism 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00409 ESCRT-I complex 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00428 eIF4F complex 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00065 GPI-anchor biosynthesis, core oligosaccharide 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 hsa_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00687 MAPK (ERK1/2) signaling 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00406 TREX complex 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00065 GPI-anchor biosynthesis, core oligosaccharide 0.999999999992585 -7.41531776927231e-12 8 0 0 31 7161 M00337 Immunoproteasome 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa_M00181 RNA polymerase III, eukaryotes 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 ko00910 Nitrogen metabolism 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa00910 Nitrogen metabolism 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 M00181 RNA polymerase III, eukaryotes 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa_M00003 Gluconeogenesis, oxaloacetate => fructose-6P 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa00360 Phenylalanine metabolism 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 ko00450 Selenocompound metabolism 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa_M00337 Immunoproteasome 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 M00003 Gluconeogenesis, oxaloacetate => fructose-6P 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 M00089 Triacylglycerol biosynthesis 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa00120 Primary bile acid biosynthesis 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 ko00120 Primary bile acid biosynthesis 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 ko00360 Phenylalanine metabolism 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa_M00089 Triacylglycerol biosynthesis 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 hsa00450 Selenocompound metabolism 0.999999999992596 -7.40351405849405e-12 17 0 0 31 7161 ko04060 Cytokine-cytokine receptor interaction 0.999999999993197 -6.80337760071893e-12 270 0 0 31 7161 hsa04060 Cytokine-cytokine receptor interaction 0.999999999993197 -6.80337760071893e-12 270 0 0 31 7161 ko05132 Salmonella infection 0.999999999993439 -6.56110214043234e-12 85 0 0 31 7161 hsa05132 Salmonella infection 0.999999999993439 -6.56110214043234e-12 85 0 0 31 7161 hsa03013 RNA transport 0.999999999993606 -6.39439592757546e-12 166 0 0 31 7161 ko03013 RNA transport 0.999999999993606 -6.39439592757546e-12 166 0 0 31 7161 ko04064 NF-kappa B signaling pathway 0.999999999993842 -6.15811634932442e-12 94 0 0 31 7161 hsa04064 NF-kappa B signaling pathway 0.999999999993842 -6.15811634932442e-12 94 0 0 31 7161 hsa04610 Complement and coagulation cascades 0.999999999994134 -5.86598229669849e-12 79 0 0 31 7161 ko03008 Ribosome biogenesis in eukaryotes 0.999999999994134 -5.86598229669849e-12 79 0 0 31 7161 hsa03008 Ribosome biogenesis in eukaryotes 0.999999999994134 -5.86598229669849e-12 79 0 0 31 7161 ko04610 Complement and coagulation cascades 0.999999999994134 -5.86598229669849e-12 79 0 0 31 7161 hsa03018 RNA degradation 0.999999999994431 -5.56898607493987e-12 77 0 0 31 7161 ko04612 Antigen processing and presentation 0.999999999994431 -5.56898607493987e-12 77 0 0 31 7161 ko03018 RNA degradation 0.999999999994431 -5.56898607493987e-12 77 0 0 31 7161 hsa04612 Antigen processing and presentation 0.999999999994431 -5.56898607493987e-12 77 0 0 31 7161 hsa04630 Jak-STAT signaling pathway 0.999999999994448 -5.55177064804052e-12 156 0 0 31 7161 ko04630 Jak-STAT signaling pathway 0.999999999994448 -5.55177064804052e-12 156 0 0 31 7161 hsa04141 Protein processing in endoplasmic reticulum 0.999999999994667 -5.33337526788112e-12 165 0 0 31 7161 ko04141 Protein processing in endoplasmic reticulum 0.999999999994667 -5.33337526788112e-12 165 0 0 31 7161 ko04640 Hematopoietic cell lineage 0.99999999999509 -4.90963446875644e-12 96 0 0 31 7161 hsa04640 Hematopoietic cell lineage 0.99999999999509 -4.90963446875644e-12 96 0 0 31 7161 M00087 beta-Oxidation 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00094 Ceramide biosynthesis 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00182 RNA polymerase I, eukaryotes 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00094 Ceramide biosynthesis 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00412 ESCRT-III complex 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00002 Glycolysis, core module involving three-carbon compounds 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00182 RNA polymerase I, eukaryotes 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00290 Holo-TFIIH complex 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00290 Holo-TFIIH complex 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00412 ESCRT-III complex 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00388 ECS complex 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00104 Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00004 Pentose phosphate pathway (Pentose phosphate cycle) 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00004 Pentose phosphate pathway (Pentose phosphate cycle) 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00388 ECS complex 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00104 Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00052 Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 hsa_M00087 beta-Oxidation 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 M00002 Glycolysis, core module involving three-carbon compounds 0.999999999995477 -4.52289014969332e-12 12 0 0 31 7161 ko05204 Chemical carcinogenesis 0.999999999995635 -4.36543766892966e-12 82 0 0 31 7161 ko04512 ECM-receptor interaction 0.999999999995635 -4.36543766892966e-12 82 0 0 31 7161 hsa05204 Chemical carcinogenesis 0.999999999995635 -4.36543766892966e-12 82 0 0 31 7161 hsa04512 ECM-receptor interaction 0.999999999995635 -4.36543766892966e-12 82 0 0 31 7161 M00013 Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00085 Fatty acid biosynthesis, elongation, mitochondria 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00284 Origin recognition complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 ko00750 Vitamin B6 metabolism 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00424 Shelterin complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00013 Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00109 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00395 Decapping complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00090 Phosphatidylcholine (PC) biosynthesis, choline => PC 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00029 Urea cycle 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00395 Decapping complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00048 Inosine monophosphate biosynthesis, PRPP + glutamine => IMP 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa00440 Phosphonate and phosphinate metabolism 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00141 C1-unit interconversion, eukaryotes 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00424 Shelterin complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 ko00440 Phosphonate and phosphinate metabolism 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00285 MCM complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00141 C1-unit interconversion, eukaryotes 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00058 Glycosaminoglycan biosynthesis, chondroitin sulfate backbone 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00284 Origin recognition complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00073 N-glycan precursor trimming 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00285 MCM complex 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00048 Inosine monophosphate biosynthesis, PRPP + glutamine => IMP 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00109 C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00073 N-glycan precursor trimming 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00085 Fatty acid biosynthesis, elongation, mitochondria 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa00750 Vitamin B6 metabolism 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 hsa_M00058 Glycosaminoglycan biosynthesis, chondroitin sulfate backbone 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 M00029 Urea cycle 0.999999999996217 -3.78264147172993e-12 6 0 0 31 7161 ko05211 Renal cell carcinoma 0.999999999996739 -3.26090367649326e-12 64 0 0 31 7161 hsa05212 Pancreatic cancer 0.999999999996739 -3.26090367649326e-12 64 0 0 31 7161 ko05212 Pancreatic cancer 0.999999999996739 -3.26090367649326e-12 64 0 0 31 7161 hsa05211 Renal cell carcinoma 0.999999999996739 -3.26090367649326e-12 64 0 0 31 7161 hsa05131 Shigellosis 0.999999999996739 -3.26090367649326e-12 64 0 0 31 7161 hsa03010 Ribosome 0.999999999997011 -2.98889719373138e-12 134 0 0 31 7161 ko03010 Ribosome 0.999999999997011 -2.98889719373138e-12 134 0 0 31 7161 hsa05416 Viral myocarditis 0.999999999998061 -1.93881479829615e-12 58 0 0 31 7161 hsa00140 Steroid hormone biosynthesis 0.999999999998061 -1.93881479829615e-12 58 0 0 31 7161 ko00140 Steroid hormone biosynthesis 0.999999999998061 -1.93881479829615e-12 58 0 0 31 7161 hsa01200 Carbon metabolism 0.999999999998719 -1.28114337280864e-12 114 0 0 31 7161 ko01200 Carbon metabolism 0.999999999998719 -1.28114337280864e-12 114 0 0 31 7161 ko01230 Biosynthesis of amino acids 1.00000000000099 9.91856146181237e-13 74 0 0 31 7161 hsa01230 Biosynthesis of amino acids 1.00000000000099 9.91856146181237e-13 74 0 0 31 7161 ko05168 Herpes simplex infection 1.00000000000149 1.4902075002242e-12 185 0 0 31 7161 hsa05168 Herpes simplex infection 1.00000000000149 1.4902075002242e-12 185 0 0 31 7161 hsa01524 Platinum drug resistance 1.00000000000171 1.71059181114016e-12 73 0 0 31 7161 ko00980 Metabolism of xenobiotics by cytochrome P450 1.00000000000171 1.71059181114016e-12 73 0 0 31 7161 ko01524 Platinum drug resistance 1.00000000000171 1.71059181114016e-12 73 0 0 31 7161 hsa00980 Metabolism of xenobiotics by cytochrome P450 1.00000000000171 1.71059181114016e-12 73 0 0 31 7161 M00427 Nuclear pore complex 1.0000000000021 2.09744487899173e-12 45 0 0 31 7161 hsa03022 Basal transcription factors 1.0000000000021 2.09744487899173e-12 45 0 0 31 7161 hsa_M00427 Nuclear pore complex 1.0000000000021 2.09744487899173e-12 45 0 0 31 7161 ko03022 Basal transcription factors 1.0000000000021 2.09744487899173e-12 45 0 0 31 7161 ko03050 Proteasome 1.0000000000021 2.09744487899173e-12 45 0 0 31 7161 hsa03050 Proteasome 1.0000000000021 2.09744487899173e-12 45 0 0 31 7161 hsa04145 Phagosome 1.00000000000284 2.83912518370539e-12 152 0 0 31 7161 ko04145 Phagosome 1.00000000000284 2.83912518370539e-12 152 0 0 31 7161