Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
7.158e-17	-37.18	synaptic membrane	cellular component	GO:0097060	400	17	19108	49	GRIN2A,HCN1,RIMS2,GABRA1,KCNMA1,GABRB2,UNC13C,DLG3,GABRD,CACNA1C,GRID2,GABRA6,GABBR2,RIMS4,LRRC7,NRXN1,NRXN3
6.725e-15	-32.63	anterograde trans-synaptic signaling	biological process	GO:0098916	415	16	18204	49	GABRD,RIMS2,NRXN1,UNC13C,GABBR2,CPLX1,GABRB2,GRID2,GABRA6,GABRA1,INSYN1,CELF4,DLG3,GRIN2A,RIMS4,PCLO
6.725e-15	-32.63	chemical synaptic transmission	biological process	GO:0007268	415	16	18204	49	GRID2,GABRA6,GABRD,NRXN1,RIMS2,UNC13C,GABBR2,CPLX1,GABRB2,RIMS4,PCLO,GABRA1,INSYN1,CELF4,GRIN2A,DLG3
1.211e-14	-32.04	trans-synaptic signaling	biological process	GO:0099537	431	16	18204	49	GRIN2A,DLG3,CELF4,INSYN1,GABRA1,RIMS4,PCLO,NRXN1,RIMS2,GABRD,GABBR2,UNC13C,GABRB2,CPLX1,GRID2,GABRA6
1.556e-14	-31.79	synapse	cellular component	GO:0045202	1473	24	19108	49	CACNA1C,GABRB2,UNC13C,ZNF804A,KCNMA1,RIMS2,GRIN2A,NRXN3,LRRC7,NRXN1,GABRA6,GABRD,DLG3,INSYN1,CELF4,GABRA1,HCN1,IL1RAPL2,PCLO,RIMS4,GABBR2,CPLX1,OLFM1,GRID2
3.213e-14	-31.07	synaptic signaling	biological process	GO:0099536	459	16	18204	49	UNC13C,GABBR2,GABRB2,CPLX1,NRXN1,GABRD,RIMS2,GRID2,GABRA6,INSYN1,DLG3,CELF4,GRIN2A,GABRA1,RIMS4,PCLO
3.675e-14	-30.93	regulation of membrane potential	biological process	GO:0042391	463	16	18204	49	GRID2,GABRA6,NRXN1,RIMS2,GABRD,CACNA1C,HCN1,GABRB2,RIMS4,SLC24A4,GRIN2A,CELF4,INSYN1,RYR2,GABRA1,KCNMA1
1.175e-13	-29.77	cell-cell signaling	biological process	GO:0007267	822	19	18204	49	GRID2,GABRA6,SMPD3,RIMS2,GABRD,NRXN1,CACNA1C,GABBR2,UNC13C,CPLX1,GABRB2,PCLO,RIMS4,RYR2,GABRA1,INSYN1,CELF4,DLG3,GRIN2A
1.897e-13	-29.29	postsynapse	cellular component	GO:0098794	646	17	19108	49	GABRA6,CPLX1,GRID2,PCLO,GABBR2,LRRC7,HCN1,GRIN2A,GABRB2,ZNF804A,DLG3,GABRD,CACNA1C,CELF4,GABRA1,INSYN1,KCNMA1
4.412e-12	-26.15	postsynaptic membrane	cellular component	GO:0045211	280	12	19108	49	LRRC7,GABBR2,GRID2,GABRA6,KCNMA1,GABRA1,CACNA1C,GABRD,GABRB2,DLG3,GRIN2A,HCN1
6.596e-12	-25.74	monoatomic ion channel activity	molecular function	GO:0005216	441	14	18094	49	KCNIP4,KCNMA1,HCN1,GRID2,RYR2,KCNT1,SLC24A4,TRPM3,GABRB2,CACNA1C,GRIN2A,GABRA6,GABRA1,GABRD
9.218e-12	-25.41	regulation of postsynaptic membrane potential	biological process	GO:0060078	106	9	18204	49	HCN1,GABRB2,GRIN2A,CELF4,INSYN1,GABRD,GABRA1,GRID2,GABRA6
1.551e-11	-24.89	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	43	16828	48	CACNA1C,CPLX1,RIMS4,AK5,GABRD,R3HDM1,ST8SIA5,GABRB2,RBFOX3,RGS7,RIMS2,SLC24A4,ZNF804A,GABBR2,KCNIP4,OPRL1,CELF6,KSR2,RBFOX1,CR2,STXBP5L,RYR2,GRID2,NRXN3,DLG3,CELF4,GRIN2A,UNC13C,ZFPM2,PPP2R5B,NRXN1,LRRC7,PCLO,HCN1,CELF5,PTPRG,GABRA1,IL1RAPL2,GABRA6,TRPM3,SMPD3,KCNT1,ASTN1
2.524e-11	-24.40	neuron projection	cellular component	GO:0043005	1331	20	19108	49	HCN1,GRIN2A,UNC13C,DLG3,OPRL1,ZNF804A,KCNIP4,GABRB2,CACNA1C,SLC24A4,GABRD,GABRA1,RGS7,OLFM1,GABRA6,CPLX1,GRID2,PCLO,GABBR2,LRRC7
3.708e-11	-24.02	channel activity	molecular function	GO:0015267	502	14	18094	49	GABRB2,TRPM3,GABRA6,GRIN2A,GABRA1,GABRD,CACNA1C,KCNIP4,HCN1,KCNMA1,SLC24A4,RYR2,KCNT1,GRID2
3.808e-11	-23.99	passive transmembrane transporter activity	molecular function	GO:0022803	503	14	18094	49	CACNA1C,GRIN2A,GABRA1,GABRA6,GABRD,TRPM3,GABRB2,GRID2,SLC24A4,RYR2,KCNT1,KCNIP4,KCNMA1,HCN1
4.860e-11	-23.75	monoatomic ion channel complex	cellular component	GO:0034702	344	12	19108	49	GABRD,CACNA1C,DLG3,KCNIP4,GABRB2,KCNMA1,GABRA1,HCN1,GRIN2A,GABRA6,RYR2,GRID2
6.002e-11	-23.54	ligand-gated monoatomic ion channel activity	molecular function	GO:0015276	186	10	18094	49	HCN1,KCNMA1,GABRB2,RYR2,GABRD,KCNT1,GRIN2A,GABRA6,GABRA1,GRID2
6.328e-11	-23.48	ligand-gated channel activity	molecular function	GO:0022834	187	10	18094	49	GRID2,GRIN2A,GABRA1,GABRA6,GABRD,KCNT1,RYR2,GABRB2,KCNMA1,HCN1
1.159e-10	-22.88	cell junction	cellular component	GO:0030054	2224	24	19108	49	GRIN2A,HCN1,RIMS2,GABRA1,CELF4,KCNMA1,INSYN1,DLG3,ZNF804A,UNC13C,GABRB2,CACNA1C,GABRD,GRID2,GABRA6,OLFM1,CPLX1,GABBR2,RIMS4,NRXN1,LRRC7,PCLO,NRXN3,IL1RAPL2
2.875e-10	-21.97	Neuronal System	REACTOME pathways	R-HSA-112316	349	11	10285	26	GABRA1,CPLX1,GRIN2A,GABBR2,GABRB2,GABRA6,DLG3,HCN1,NRXN3,NRXN1,KCNMA1
6.990e-10	-21.08	transmembrane transporter complex	cellular component	GO:1902495	434	12	19108	49	GRID2,RYR2,GABRA6,GRIN2A,HCN1,GABRA1,KCNMA1,DLG3,KCNIP4,GABRB2,CACNA1C,GABRD
7.142e-10	-21.06	gated channel activity	molecular function	GO:0022836	320	11	18094	49	HCN1,KCNMA1,GABRB2,RYR2,KCNT1,GABRD,GABRA6,GABRA1,GRIN2A,GRID2,CACNA1C
7.413e-10	-21.02	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	27	16828	48	RIMS4,AK5,MYT1L,OLFM1,R3HDM1,ST8SIA5,RIMS2,ZNF804A,GABBR2,KSR2,STXBP5L,RYR2,GRID2,NRXN3,CELF4,ZFPM2,GRIN2A,UNC13C,LRRC7,CELF5,PCLO,PTPRG,IL1RAPL2,GABRA1,TRPM3,KCNT1,ASTN1
1.005e-09	-20.72	plasma membrane region	cellular component	GO:0098590	1278	18	19108	49	GRID2,GABRA6,NRXN1,LRRC7,RIMS4,GABBR2,NRXN3,GRIN2A,RIMS2,HCN1,KCNMA1,GABRA1,CACNA1C,GABRD,SLC24A4,DLG3,UNC13C,GABRB2
1.386e-09	-20.40	transporter complex	cellular component	GO:1990351	461	12	19108	49	GABRA6,GRID2,RYR2,HCN1,GRIN2A,GABRB2,KCNIP4,DLG3,CACNA1C,GABRD,GABRA1,KCNMA1
1.687e-09	-20.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	15	16828	48	OLFM1,ZFPM2,GRIN2A,CELF4,IL1RAPL2,PTPRG,HCN1,PCLO,STXBP5L,KSR2,ZNF804A,GABBR2,GALNT9,RYR2,GRID2
1.774e-09	-20.15	GABA receptor complex	cellular component	GO:1902710	21	5	19108	49	GABRD,GABRA6,GABRB2,GABBR2,GABRA1
1.893e-09	-20.09	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	26	16828	48	ASTN1,KCNT1,IL1RAPL2,GABRA1,CELF5,PCLO,PTPRG,LRRC7,CELF4,ZFPM2,GRIN2A,UNC13C,NRXN3,GRID2,RYR2,KSR2,STXBP5L,ZNF804A,GABBR2,ST8SIA5,RIMS2,R3HDM1,AK5,MYT1L,OLFM1,RIMS4
2.851e-09	-19.68	regulation of biological quality	biological process	GO:0065008	2936	26	18204	49	NRXN1,CACNA1C,UNC13C,GABRB2,CPLX1,HCN1,OLFM1,GRID2,CELF4,DLG3,GRIN2A,KCNMA1,PCLO,GABRD,RIMS2,IL1RAPL2,OPRL1,LRRC7,SMPD3,GABRA6,INSYN1,RYR2,GABRA1,ZNF804A,RIMS4,SLC24A4
3.003e-09	-19.62	GABA receptor activity	molecular function	GO:0016917	22	5	18094	49	GABRA6,GABRA1,GABRB2,GABRD,GABBR2
3.667e-09	-19.42	cell projection	cellular component	GO:0042995	2398	23	19108	49	ZNF804A,UNC13C,GABRB2,KCNIP4,CACNA1C,GRIN2A,RIMS2,NRXN1,LRRC7,NRXN3,GABRA6,GABRA1,RGS7,DLG3,OPRL1,GABRD,SLC24A4,HCN1,GABBR2,PCLO,GRID2,OLFM1,CPLX1
5.990e-09	-18.93	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	molecular function	GO:1904315	53	6	18094	49	GRID2,GABRD,GRIN2A,GABRA1,GABRA6,GABRB2
7.101e-09	-18.76	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	14	18094	49	TRPM3,GABRB2,CACNA1C,GABRD,GABRA1,GRIN2A,GABRA6,KCNMA1,HCN1,KCNIP4,GRID2,RYR2,KCNT1,SLC24A4
7.533e-09	-18.70	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	molecular function	GO:0099529	55	6	18094	49	GABRD,GABRB2,GABRA6,GRIN2A,GABRA1,GRID2
1.069e-08	-18.35	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	44	16828	48	SLC24A4,ZNF804A,CR2,KSR2,GRID2,RYR2,CACNA1C,RBFOX3,RGS7,GABRA6,SMPD3,KCNT1,ASTN1,NRXN1,PPP2R5B,PTPRG,HCN1,PCLO,KCNMA1,CELF6,GABBR2,KCNIP4,STXBP5L,RBFOX1,NRXN3,RIMS4,CPLX1,GABRD,MYT1L,OLFM1,AK5,R3HDM1,RIMS2,GABRB2,ST8SIA5,TRPM3,ZFPM2,UNC13C,GRIN2A,CELF4,LRRC7,CELF5,GABRA1,IL1RAPL2
1.075e-08	-18.35	synaptic transmission, GABAergic	biological process	GO:0051932	28	5	18204	49	GABRA1,GABRD,GABRA6,GABRB2,GABBR2
1.161e-08	-18.27	transmitter-gated channel activity	molecular function	GO:0022835	59	6	18094	49	GABRB2,GRID2,GABRD,GABRA6,GABRA1,GRIN2A
1.161e-08	-18.27	transmitter-gated monoatomic ion channel activity	molecular function	GO:0022824	59	6	18094	49	GRID2,GABRD,GABRA1,GABRB2,GABRA6,GRIN2A
1.296e-08	-18.16	gamma-aminobutyric acid signaling pathway	biological process	GO:0007214	29	5	18204	49	GABBR2,GABRB2,GABRA6,GABRD,GABRA1
1.486e-08	-18.02	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	18	16828	48	SLC24A4,ZNF804A,GABRA6,TRPM3,RBFOX1,STXBP5L,RYR2,KCNT1,NRXN3,GRIN2A,UNC13C,ZFPM2,PPP2R5B,MYT1L,LRRC7,HCN1,PTPRG,ST8SIA5
1.535e-08	-17.99	monoatomic ion transmembrane transport	biological process	GO:0034220	804	14	18204	49	TRPM3,SLC24A4,GRIN2A,KCNT1,KCNIP4,GABRA1,RYR2,KCNMA1,GABRA6,GRID2,GABRD,GABRB2,HCN1,CACNA1C
1.742e-08	-17.87	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	18	16828	48	KCNT1,RYR2,NRXN3,GABRA6,ZNF804A,SLC24A4,STXBP5L,RBFOX1,TRPM3,PTPRG,HCN1,ST8SIA5,ZFPM2,UNC13C,GRIN2A,MYT1L,LRRC7,PPP2R5B
2.628e-08	-17.45	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	18	16828	48	NRXN3,GALNT9,GRID2,RYR2,TRPM3,KSR2,STXBP5L,CR2,GABBR2,ZNF804A,GABRA6,IL1RAPL2,RBFOX3,HCN1,PCLO,PTPRG,ZFPM2,GRIN2A
2.751e-08	-17.41	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	22	16828	48	ASTN1,KCNT1,LRRC7,CELF4,GRIN2A,UNC13C,IL1RAPL2,PCLO,HCN1,PTPRG,KSR2,CR2,STXBP5L,GABBR2,ZNF804A,NRXN3,RYR2,GRID2,AK5,CACNA1C,RBFOX3,RIMS2
2.751e-08	-17.41	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	22	16828	48	RBFOX3,RIMS2,AK5,CACNA1C,NRXN3,RYR2,GRID2,KSR2,STXBP5L,CR2,ZNF804A,GABBR2,IL1RAPL2,PCLO,HCN1,PTPRG,LRRC7,CELF4,GRIN2A,UNC13C,ASTN1,KCNT1
3.225e-08	-17.25	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	22	16828	48	CELF4,GRIN2A,UNC13C,LRRC7,PCLO,HCN1,PTPRG,IL1RAPL2,KCNT1,ASTN1,CACNA1C,AK5,RBFOX3,RIMS2,GABBR2,ZNF804A,KSR2,CR2,STXBP5L,GRID2,RYR2,NRXN3
3.304e-08	-17.23	postsynaptic neurotransmitter receptor activity	molecular function	GO:0098960	70	6	18094	49	GABRB2,GRIN2A,GABRA6,GABRA1,GABRD,GRID2
3.375e-08	-17.20	inorganic ion transmembrane transport	biological process	GO:0098660	715	13	18204	49	CACNA1C,HCN1,GABRB2,GABRD,GABRA6,KCNMA1,GABRA1,RYR2,KCNIP4,KCNT1,GRIN2A,SLC24A4,TRPM3
3.563e-08	-17.15	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	13	18094	49	KCNMA1,HCN1,KCNIP4,KCNT1,SLC24A4,RYR2,TRPM3,GABRB2,CACNA1C,GABRD,GABRA6,GABRA1,GRIN2A
3.921e-08	-17.05	extracellular ligand-gated monoatomic ion channel activity	molecular function	GO:0005230	72	6	18094	49	GABRB2,GABRD,GRIN2A,GABRA1,GABRA6,GRID2
7.391e-08	-16.42	CELF3/4/5/6_RRM1	interpro domains	IPR034648	4	3	18521	50	CELF5,CELF4,CELF6
8.128e-08	-16.33	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	27	16828	48	SMPD3,TRPM3,ASTN1,ZFPM2,UNC13C,GRIN2A,CELF4,PTPRG,CELF5,HCN1,PCLO,KCNMA1,IL1RAPL2,TTC9B,ZNF804A,CR2,RBFOX1,GRID2,RYR2,NRXN3,RIMS4,CACNA1C,MYT1L,AK5,RIMS2,RGS7,GABRB2
8.128e-08	-16.33	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	27	16828	48	SMPD3,TRPM3,ASTN1,ZFPM2,UNC13C,GRIN2A,CELF4,PTPRG,HCN1,CELF5,PCLO,KCNMA1,IL1RAPL2,TTC9B,ZNF804A,CR2,RBFOX1,RYR2,GRID2,NRXN3,RIMS4,CACNA1C,MYT1L,AK5,RIMS2,RGS7,GABRB2
8.861e-08	-16.24	presynaptic active zone cytoplasmic component	cellular component	GO:0098831	17	4	19108	49	RIMS4,UNC13C,PCLO,RIMS2
9.568e-08	-16.16	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	38	16828	48	NRXN3,GRID2,RYR2,RBFOX1,KSR2,CR2,STXBP5L,ZNF804A,KCNIP4,OPRL1,ST8SIA5,GABRB2,RBFOX3,RGS7,RIMS2,R3HDM1,GABRD,MYT1L,CACNA1C,RIMS4,ASTN1,GALNT9,KCNT1,TRPM3,SMPD3,GABRA6,GABRA1,IL1RAPL2,KCNMA1,PCLO,HCN1,PTPRG,PPP2R5B,NRXN1,LRRC7,UNC13C,GRIN2A,ZFPM2
9.642e-08	-16.15	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	18	16828	48	GABBR2,ZNF804A,GABRA6,KSR2,TRPM3,CR2,STXBP5L,RYR2,GRID2,NRXN3,GALNT9,ZFPM2,GRIN2A,HCN1,PCLO,PTPRG,RBFOX3,IL1RAPL2
1.271e-07	-15.88	neurotransmitter secretion	biological process	GO:0007269	88	6	18204	49	RIMS2,NRXN1,PCLO,RIMS4,CPLX1,UNC13C
1.271e-07	-15.88	signal release from synapse	biological process	GO:0099643	88	6	18204	49	RIMS4,PCLO,CPLX1,UNC13C,NRXN1,RIMS2
1.296e-07	-15.86	somatodendritic compartment	cellular component	GO:0036477	842	13	19108	49	GRIN2A,HCN1,GABRA1,ZNF804A,KCNIP4,CACNA1C,GABRD,GRID2,ASTN1,OLFM1,GABRA6,CPLX1,NRXN1
1.304e-07	-15.85	transmembrane transporter activity	molecular function	GO:0022857	1110	15	18094	49	CPLX1,KCNIP4,HCN1,KCNMA1,GRID2,KCNT1,RYR2,SLC24A4,TRPM3,GABRB2,CACNA1C,GABRA1,GRIN2A,GABRA6,GABRD
1.305e-07	-15.85	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	36	16828	48	GABRB2,RIMS2,MYT1L,GABRD,CACNA1C,NRXN3,RYR2,GRID2,RBFOX1,KSR2,CR2,STXBP5L,KCNIP4,ZNF804A,SLC24A4,GABBR2,OPRL1,IL1RAPL2,GABRA1,KCNMA1,PCLO,CELF5,HCN1,PTPRG,PPP2R5B,NRXN1,LRRC7,CELF4,GRIN2A,UNC13C,ZFPM2,ASTN1,GALNT9,KCNT1,TRPM3,GABRA6
1.437e-07	-15.76	plasma membrane	cellular component	GO:0005886	5538	32	19108	49	KCNT1,HCN1,GABRA1,RGS7,OPRL1,DLG3,SLC24A4,GABRD,GRID2,CR2,GABBR2,RIMS4,IL1RAPL2,GRIN2A,TRPM3,STXBP5L,RIMS2,KCNMA1,UNC13C,ZNF804A,GABRB2,KCNIP4,CACNA1C,RYR2,GABRA6,ASTN1,SMPD3,PTPRG,NRXN1,KSR2,LRRC7,NRXN3
1.438e-07	-15.76	GABA-A receptor complex	cellular component	GO:1902711	19	4	19108	49	GABRD,GABRB2,GABRA6,GABRA1
1.473e-07	-15.73	monoatomic ion transport	biological process	GO:0006811	964	14	18204	49	KCNIP4,KCNT1,GRIN2A,RYR2,GABRA1,KCNMA1,TRPM3,SLC24A4,GABRD,CACNA1C,GABRB2,HCN1,GRID2,GABRA6
1.785e-07	-15.54	GABA-A receptor activity	molecular function	GO:0004890	19	4	18094	49	GABRA1,GABRB2,GABRA6,GABRD
2.221e-07	-15.32	monoatomic cation channel activity	molecular function	GO:0005261	331	9	18094	49	KCNIP4,HCN1,KCNMA1,TRPM3,GRIN2A,RYR2,SLC24A4,KCNT1,CACNA1C
2.256e-07	-15.30	presynaptic membrane	cellular component	GO:0042734	168	7	19108	49	NRXN1,RIMS4,UNC13C,NRXN3,GRIN2A,RIMS2,HCN1
2.357e-07	-15.26	neurotransmitter receptor activity	molecular function	GO:0030594	97	6	18094	49	GRIN2A,GABRA1,GABRB2,GABRA6,GABRD,GRID2
2.662e-07	-15.14	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	15	16828	48	NRXN3,GRID2,RYR2,KCNT1,KSR2,SMPD3,ZNF804A,IL1RAPL2,RGS7,HCN1,PCLO,PTPRG,LRRC7,CELF4,ZFPM2
2.687e-07	-15.13	cell periphery	cellular component	GO:0071944	6020	33	19108	49	CR2,GRID2,IL1RAPL2,PCLO,GABBR2,RIMS4,HCN1,KCNT1,GABRD,SLC24A4,DLG3,OPRL1,RGS7,GABRA1,PTPRG,ASTN1,GABRA6,SMPD3,RYR2,NRXN3,NRXN1,KSR2,LRRC7,RIMS2,STXBP5L,TRPM3,GRIN2A,CACNA1C,UNC13C,ZNF804A,GABRB2,KCNIP4,KCNMA1
2.884e-07	-15.06	humerus	COSMIC cancer mutations	humerus	546	11	16828	48	PCLO,R3HDM1,HCN1,IL1RAPL2,GRIN2A,ZFPM2,RIMS4,GRID2,RYR2,NRXN3,KSR2
2.942e-07	-15.04	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	20	19108	49	GRID2,CPLX1,OLFM1,GABRA6,LRRC7,GABBR2,PCLO,GRIN2A,HCN1,RGS7,GABRA1,CACNA1C,SLC24A4,GABRD,KCNIP4,GABRB2,OPRL1,DLG3,ZNF804A,UNC13C
3.099e-07	-14.99	Nicotine addiction	KEGG pathways	ko05033	40	5	7161	27	GABRA1,GABRA6,GABRB2,GABRD,GRIN2A
3.099e-07	-14.99	Nicotine addiction	KEGG pathways	hsa05033	40	5	7161	27	GABRA6,GABRA1,GABRD,GABRB2,GRIN2A
3.167e-07	-14.97	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	38	16828	48	CELF6,OPRL1,GABBR2,SLC24A4,CR2,STXBP5L,RBFOX1,KSR2,RYR2,DLG3,NRXN3,CACNA1C,GABRD,MYT1L,OLFM1,AK5,R3HDM1,RIMS2,RGS7,GABRB2,GABRA6,SMPD3,TRPM3,KCNT1,GALNT9,ASTN1,ZFPM2,GRIN2A,UNC13C,CELF4,LRRC7,NRXN1,PTPRG,HCN1,PCLO,KCNMA1,IL1RAPL2,GABRA1
3.167e-07	-14.97	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	38	16828	48	RIMS2,RGS7,GABRB2,R3HDM1,MYT1L,GABRD,OLFM1,AK5,CACNA1C,DLG3,NRXN3,RYR2,STXBP5L,CR2,RBFOX1,KSR2,CELF6,OPRL1,GABBR2,SLC24A4,KCNMA1,IL1RAPL2,GABRA1,PTPRG,HCN1,PCLO,LRRC7,NRXN1,ZFPM2,GRIN2A,UNC13C,CELF4,GALNT9,ASTN1,KCNT1,SMPD3,TRPM3,GABRA6
3.316e-07	-14.92	GABAA/Glycine_rcpt	interpro domains	IPR006028	22	4	18521	50	GABRB2,GABRA1,GABRD,GABRA6
3.368e-07	-14.90	membrane protein complex	cellular component	GO:0098796	1261	15	19108	49	RYR2,GRID2,CPLX1,GABRA6,GABBR2,GRIN2A,STXBP5L,HCN1,KCNMA1,GABRA1,GABRD,CACNA1C,DLG3,GABRB2,KCNIP4
3.602e-07	-14.84	regulation of alternative mRNA splicing, via spliceosome	biological process	GO:0000381	55	5	18204	49	CELF4,RBFOX3,CELF5,RBFOX1,CELF6
4.023e-07	-14.73	transporter activity	molecular function	GO:0005215	1211	15	18094	49	KCNIP4,CPLX1,HCN1,KCNMA1,RYR2,KCNT1,SLC24A4,GRID2,GABRB2,TRPM3,GRIN2A,GABRA1,GABRA6,GABRD,CACNA1C
4.239e-07	-14.67	lymph_node	COSMIC cancer mutations	lymph_node	1703	18	16828	48	TRPM3,KSR2,GABBR2,DLG3,ASTN1,NRXN3,GRID2,RYR2,LRRC7,MYT1L,ZFPM2,GRIN2A,UNC13C,CELF4,RIMS2,RGS7,IL1RAPL2,PCLO
4.550e-07	-14.60	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	20	16828	48	ZNF804A,GABBR2,GABRA6,KSR2,STXBP5L,RYR2,GRID2,ASTN1,NRXN3,CELF4,ZFPM2,UNC13C,GRIN2A,AK5,LRRC7,OLFM1,HCN1,PCLO,PTPRG,IL1RAPL2
4.550e-07	-14.60	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	20	16828	48	GRID2,RYR2,ASTN1,NRXN3,GABRA6,ZNF804A,GABBR2,STXBP5L,KSR2,PTPRG,HCN1,PCLO,IL1RAPL2,ZFPM2,UNC13C,GRIN2A,CELF4,LRRC7,OLFM1,AK5
5.571e-07	-14.40	mouth	COSMIC cancer mutations	mouth	9004	42	16828	48	RBFOX3,RGS7,RIMS2,ST8SIA5,GABRB2,R3HDM1,GABRD,MYT1L,RIMS4,CACNA1C,DLG3,NRXN3,GRID2,RYR2,STXBP5L,CR2,KSR2,RBFOX1,OPRL1,GABBR2,KCNIP4,SLC24A4,ZNF804A,IL1RAPL2,GABRA1,KCNMA1,PTPRG,PCLO,HCN1,CELF5,LRRC7,PPP2R5B,NRXN1,UNC13C,GRIN2A,ZFPM2,GALNT9,ASTN1,KCNT1,SMPD3,TRPM3,GABRA6
6.671e-07	-14.22	signal release	biological process	GO:0023061	188	7	18204	49	SMPD3,CPLX1,UNC13C,NRXN1,RIMS2,PCLO,RIMS4
6.977e-07	-14.18	GABAergic synapse	KEGG pathways	hsa04727	88	6	7161	27	GABRD,GABRB2,GABRA6,GABRA1,CACNA1C,GABBR2
6.977e-07	-14.18	GABAergic synapse	KEGG pathways	ko04727	88	6	7161	27	GABRA6,GABRD,GABBR2,CACNA1C,GABRA1,GABRB2
7.162e-07	-14.15	synaptic vesicle exocytosis	biological process	GO:0016079	63	5	18204	49	RIMS2,PCLO,RIMS4,UNC13C,CPLX1
7.270e-07	-14.13	synapse assembly	biological process	GO:0007416	118	6	18204	49	GABRA1,NRXN1,PCLO,GABRA6,GRID2,GABRB2
7.439e-07	-14.11	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	10	16828	48	NRXN3,IL1RAPL2,GRID2,TRPM3,MYT1L,CELF4,GABBR2,UNC13C,GRIN2A,ZFPM2
7.902e-07	-14.05	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	7	10285	26	CPLX1,GRIN2A,DLG3,GABRA6,GABRA1,GABRB2,GABBR2
8.318e-07	-14.00	receptor complex	cellular component	GO:0043235	409	9	19108	49	GABRD,DLG3,GABRB2,GABBR2,GABRA1,CR2,GABRA6,GRIN2A,GRID2
8.756e-07	-13.95	GABAARECEPTR	prints domains	PR00253	22	4	5227	19	GABRA6,GABRA1,GABRD,GABRB2
8.795e-07	-13.94	cytoskeleton of presynaptic active zone	cellular component	GO:0048788	8	3	19108	49	RIMS4,RIMS2,PCLO
1.066e-06	-13.75	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	35	16828	48	ZFPM2,GRIN2A,UNC13C,LRRC7,PPP2R5B,PTPRG,CELF5,HCN1,PCLO,KCNMA1,GABRA1,GABRA6,SMPD3,TRPM3,KCNT1,ASTN1,RIMS4,CACNA1C,MYT1L,GABRD,R3HDM1,RBFOX3,RGS7,OPRL1,SLC24A4,ZNF804A,KCNIP4,GABBR2,STXBP5L,CR2,RBFOX1,KSR2,GRID2,RYR2,DLG3
1.345e-06	-13.52	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME pathways	R-HSA-112314	146	6	10285	26	GABRB2,GABBR2,GRIN2A,DLG3,GABRA1,GABRA6
1.463e-06	-13.44	presynapse	cellular component	GO:0098793	569	10	19108	49	GRIN2A,HCN1,CPLX1,RIMS2,RIMS4,NRXN1,ZNF804A,PCLO,UNC13C,NRXN3
1.677e-06	-13.30	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	13	16828	48	TRPM3,OPRL1,GABBR2,ZNF804A,GALNT9,NRXN3,KCNT1,MYT1L,ZFPM2,UNC13C,CACNA1C,RIMS2,PCLO
1.677e-06	-13.30	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	13	16828	48	TRPM3,GABBR2,ZNF804A,OPRL1,NRXN3,GALNT9,KCNT1,MYT1L,CACNA1C,ZFPM2,UNC13C,RIMS2,PCLO
1.757e-06	-13.25	presynaptic active zone	cellular component	GO:0048786	79	5	19108	49	RIMS2,PCLO,UNC13C,HCN1,RIMS4
1.759e-06	-13.25	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	21	16828	48	CR2,KSR2,GABBR2,ZNF804A,NRXN3,ASTN1,KCNT1,GRID2,RYR2,GABRD,LRRC7,GRIN2A,RIMS4,ZFPM2,CELF4,CPLX1,IL1RAPL2,ST8SIA5,GABRB2,PTPRG,HCN1
1.884e-06	-13.18	cell cortex region	cellular component	GO:0099738	35	4	19108	49	PCLO,UNC13C,RIMS2,RIMS4
1.935e-06	-13.16	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	8	16828	48	KSR2,GRIN2A,ZFPM2,RIMS4,NRXN3,IL1RAPL2,GRID2,HCN1
1.980e-06	-13.13	neurotransmitter transport	biological process	GO:0006836	140	6	18204	49	NRXN1,RIMS2,UNC13C,CPLX1,RIMS4,PCLO
2.102e-06	-13.07	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	10	16828	48	NRXN3,IL1RAPL2,HCN1,GRID2,PTPRG,KSR2,ZNF804A,RIMS4,ZFPM2,GRIN2A
2.167e-06	-13.04	trunk	COSMIC cancer mutations	trunk	3554	25	16828	48	NRXN3,RYR2,GRID2,KSR2,RBFOX1,CR2,STXBP5L,ZNF804A,GABBR2,RIMS2,RGS7,RBFOX3,R3HDM1,MYT1L,CACNA1C,ASTN1,KCNT1,GABRA6,GABRA1,HCN1,CELF5,PTPRG,NRXN1,ZFPM2,GRIN2A
2.215e-06	-13.02	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	28	16828	48	KCNT1,ASTN1,GABRA6,TRPM3,HCN1,PCLO,PTPRG,IL1RAPL2,ZFPM2,GRIN2A,UNC13C,PPP2R5B,LRRC7,RYR2,GRID2,NRXN3,ZNF804A,GABBR2,CELF6,KSR2,STXBP5L,R3HDM1,ST8SIA5,RIMS2,RGS7,CACNA1C,MYT1L,OLFM1
2.215e-06	-13.02	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	28	16828	48	GRID2,RYR2,NRXN3,GABBR2,ZNF804A,CELF6,KSR2,STXBP5L,R3HDM1,ST8SIA5,RIMS2,RGS7,CACNA1C,MYT1L,OLFM1,KCNT1,ASTN1,GABRA6,TRPM3,HCN1,PCLO,PTPRG,IL1RAPL2,ZFPM2,GRIN2A,UNC13C,PPP2R5B,LRRC7
2.463e-06	-12.91	postsynaptic specialization	cellular component	GO:0099572	345	8	19108	49	GRID2,GRIN2A,DLG3,PCLO,GABRB2,CACNA1C,LRRC7,INSYN1
2.465e-06	-12.91	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	9	18094	49	RYR2,KCNT1,SLC24A4,GRIN2A,CACNA1C,HCN1,KCNMA1,KCNIP4,TRPM3
2.577e-06	-12.87	presynaptic cytoskeleton	cellular component	GO:0099569	11	3	19108	49	PCLO,RIMS2,RIMS4
3.274e-06	-12.63	cell communication	biological process	GO:0007154	5010	29	18204	49	INSYN1,RYR2,KSR2,GABRA1,SLC24A4,RIMS4,RIMS2,GABRD,IL1RAPL2,CR2,SMPD3,GABRA6,PPP2R5B,OPRL1,CELF4,GRIN2A,DLG3,RGS7,PCLO,CACNA1C,GABBR2,UNC13C,CPLX1,HCN1,GABRB2,NRXN1,PTPRG,GRID2,OLFM1
3.353e-06	-12.61	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	32	16828	48	RGS7,RIMS2,GABRB2,CACNA1C,MYT1L,OLFM1,AK5,GRID2,RYR2,NRXN3,OPRL1,ZNF804A,SLC24A4,CR2,STXBP5L,RBFOX1,PTPRG,PCLO,HCN1,GABRA1,IL1RAPL2,KCNMA1,UNC13C,GRIN2A,ZFPM2,CELF4,LRRC7,KCNT1,ASTN1,GABRA6,SMPD3,TRPM3
3.353e-06	-12.61	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	32	16828	48	ASTN1,KCNT1,TRPM3,SMPD3,GABRA6,IL1RAPL2,GABRA1,KCNMA1,PCLO,HCN1,PTPRG,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,NRXN3,RYR2,GRID2,RBFOX1,CR2,STXBP5L,SLC24A4,ZNF804A,OPRL1,GABRB2,RGS7,RIMS2,AK5,OLFM1,MYT1L,CACNA1C
3.800e-06	-12.48	transmembrane transport	biological process	GO:0055085	1264	14	18204	49	TRPM3,SLC24A4,RYR2,GABRA1,KCNIP4,KCNT1,GRIN2A,KCNMA1,GRID2,GABRA6,GABRD,CACNA1C,HCN1,GABRB2
4.034e-06	-12.42	GABA A receptor activation	REACTOME pathways	R-HSA-977441	13	3	10285	26	GABRA6,GABRA1,GABRB2
4.318e-06	-12.35	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	24	16828	48	ASTN1,TRPM3,PTPRG,PCLO,CELF5,GABRA1,KCNMA1,GRIN2A,UNC13C,ZFPM2,CELF4,NRXN1,RYR2,GRID2,KCNIP4,ZNF804A,CR2,STXBP5L,KSR2,R3HDM1,RGS7,RBFOX3,RIMS2,CACNA1C
4.502e-06	-12.31	transport	biological process	GO:0006810	3615	24	18204	49	KCNT1,GRIN2A,KCNMA1,PCLO,TRPM3,NRXN1,CACNA1C,STXBP5L,UNC13C,HCN1,CPLX1,GABRB2,GRID2,RYR2,GABRA1,KCNIP4,RIMS4,SLC24A4,GABRD,RIMS2,RBFOX1,LRRC7,SMPD3,GABRA6
5.001e-06	-12.21	export from cell	biological process	GO:0140352	485	9	18204	49	UNC13C,STXBP5L,CPLX1,NRXN1,RIMS2,SLC24A4,SMPD3,PCLO,RIMS4
5.074e-06	-12.19	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	27	16828	48	SMPD3,TRPM3,GABRA6,ASTN1,LRRC7,PPP2R5B,GRIN2A,KCNMA1,GABRA1,HCN1,PCLO,STXBP5L,RBFOX1,KSR2,CELF6,ZNF804A,SLC24A4,DLG3,NRXN3,RYR2,MYT1L,AK5,CACNA1C,RIMS2,RBFOX3,RGS7,R3HDM1
5.157e-06	-12.18	Neuroactive ligand-receptor interaction	KEGG pathways	ko04080	276	8	7161	27	OPRL1,GABRB2,GABRA1,GABBR2,GABRD,GABRA6,GRID2,GRIN2A
5.157e-06	-12.18	Neuroactive ligand-receptor interaction	KEGG pathways	hsa04080	276	8	7161	27	GABRB2,OPRL1,GABRA1,GABBR2,GABRD,GABRA6,GRID2,GRIN2A
5.237e-06	-12.16	GABA-gated chloride ion channel activity	molecular function	GO:0022851	13	3	18094	49	GABRB2,GABRA1,GABRA6
5.366e-06	-12.14	Neurotransmitter_ion_chnl_CS	interpro domains	IPR018000	43	4	18521	50	GABRD,GABRA1,GABRB2,GABRA6
5.891e-06	-12.04	Neurotrans-gated_channel_TM	interpro domains	IPR006029	44	4	18521	50	GABRA6,GABRD,GABRA1,GABRB2
6.351e-06	-11.97	Neur_chan_memb	pfam domains	PF02932	44	4	17795	49	GABRB2,GABRD,GABRA1,GABRA6
6.453e-06	-11.95	Neur_chan_lig-bd_sf	interpro domains	IPR036734	45	4	18521	50	GABRD,GABRA1,GABRB2,GABRA6
6.453e-06	-11.95	Neuro_actylchol_rec	interpro domains	IPR038050	45	4	18521	50	GABRA6,GABRA1,GABRB2,GABRD
6.453e-06	-11.95	Neuro-gated_channel_TM_sf	interpro domains	IPR036719	45	4	18521	50	GABRD,GABRB2,GABRA1,GABRA6
6.453e-06	-11.95	Neur_channel	interpro domains	IPR006201	45	4	18521	50	GABRA1,GABRB2,GABRD,GABRA6
6.453e-06	-11.95	Neur_chan_lig-bd	interpro domains	IPR006202	45	4	18521	50	GABRB2,GABRA1,GABRD,GABRA6
6.956e-06	-11.88	Neur_chan_LBD	pfam domains	PF02931	45	4	17795	49	GABRA1,GABRA6,GABRD,GABRB2
7.860e-06	-11.75	-	gene3d domains	1.10.287.70	148	6	14470	47	CACNA1C,KCNMA1,HCN1,RYR2,GRID2,KCNT1
8.098e-06	-11.72	cerebellum	COSMIC cancer mutations	cerebellum	769	11	16828	48	GRID2,RYR2,NRXN3,PCLO,RGS7,IL1RAPL2,CELF4,CACNA1C,ZFPM2,NRXN1,MYT1L
8.155e-06	-11.72	NEUROTR_ION_CHANNEL	prosite domains	PS00236	43	4	12186	37	GABRD,GABRA1,GABRA6,GABRB2
8.978e-06	-11.62	modulation of excitatory postsynaptic potential	biological process	GO:0098815	49	4	18204	49	CELF4,GRIN2A,NRXN1,RIMS2
1.001e-05	-11.51	neuron cell-cell adhesion	biological process	GO:0007158	16	3	18204	49	NRXN3,ASTN1,NRXN1
1.033e-05	-11.48	signaling	biological process	GO:0023052	4968	28	18204	49	OLFM1,GRID2,PTPRG,NRXN1,GABRB2,CPLX1,UNC13C,CACNA1C,GABBR2,PCLO,RGS7,GRIN2A,DLG3,CELF4,OPRL1,PPP2R5B,GABRA6,SMPD3,CR2,IL1RAPL2,RIMS2,GABRD,RIMS4,SLC24A4,GABRA1,KSR2,RYR2,INSYN1
1.078e-05	-11.44	GABA receptor activation	REACTOME pathways	R-HSA-977443	56	4	10285	26	GABRB2,GABRA6,GABRA1,GABBR2
1.105e-05	-11.41	Ion_trans_dom	interpro domains	IPR005821	109	5	18521	50	RYR2,KCNMA1,CACNA1C,TRPM3,HCN1
1.185e-05	-11.34	regulation of mRNA splicing, via spliceosome	biological process	GO:0048024	111	5	18204	49	RBFOX3,CELF4,CELF5,CELF6,RBFOX1
1.210e-05	-11.32	Ion_trans	pfam domains	PF00520	109	5	17795	49	KCNMA1,RYR2,CACNA1C,HCN1,TRPM3
1.227e-05	-11.31	bone	COSMIC cancer mutations	bone	8157	38	16828	48	OLFM1,GABRD,MYT1L,AK5,RIMS4,CACNA1C,RGS7,GABRB2,ST8SIA5,R3HDM1,STXBP5L,CR2,KSR2,CELF6,GABBR2,ZNF804A,SLC24A4,KCNIP4,NRXN3,RYR2,GRID2,LRRC7,NRXN1,PPP2R5B,ZFPM2,GRIN2A,UNC13C,CELF4,IL1RAPL2,PTPRG,HCN1,PCLO,SMPD3,TRPM3,GABRA6,GALNT9,ASTN1,KCNT1
1.231e-05	-11.30	brainstem	COSMIC cancer mutations	brainstem	3102	22	16828	48	GRIN2A,RIMS4,ZFPM2,CELF4,CPLX1,LRRC7,GABRD,PTPRG,HCN1,IL1RAPL2,ST8SIA5,GABRB2,OPRL1,ZNF804A,GABBR2,CR2,KSR2,KCNT1,GRID2,RYR2,NRXN3,ASTN1
1.241e-05	-11.30	Interactions of neurexins and neuroligins at synapses	REACTOME pathways	R-HSA-6794361	58	4	10285	26	NRXN3,NRXN1,GRIN2A,DLG3
1.243e-05	-11.30	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	10	16828	48	CACNA1C,CELF4,NRXN1,MYT1L,GRID2,PCLO,RYR2,NRXN3,IL1RAPL2,RGS7
1.260e-05	-11.28	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	10	16828	48	RYR2,GRID2,PCLO,IL1RAPL2,RGS7,NRXN3,CACNA1C,CELF4,MYT1L,NRXN1
1.271e-05	-11.27	chloride channel complex	cellular component	GO:0034707	56	4	19108	49	GABRB2,GABRA6,GABRD,GABRA1
1.320e-05	-11.24	Neurotransmitter-gated ion-channel ligand-binding domain	gene3d domains	2.70.170.10	45	4	14470	47	GABRA1,GABRB2,GABRA6,GABRD
1.320e-05	-11.24	Neurotransmitter-gated ion-channel transmembrane domain	gene3d domains	1.20.58.390	45	4	14470	47	GABRA1,GABRD,GABRA6,GABRB2
1.376e-05	-11.19	Insulin secretion	KEGG pathways	hsa04911	85	5	7161	27	RIMS2,RYR2,KCNMA1,PCLO,CACNA1C
1.407e-05	-11.17	NRIONCHANNEL	prints domains	PR00252	43	4	5227	19	GABRB2,GABRD,GABRA6,GABRA1
1.414e-05	-11.17	NLGN1 (neuroligin 1)	protein interactions	22871	19	3	19454	49	NRXN3,DLG3,NRXN1
1.454e-05	-11.14	calcium ion-regulated exocytosis of neurotransmitter	biological process	GO:0048791	18	3	18204	49	UNC13C,RIMS2,RIMS4
1.471e-05	-11.13	human chr5q34	chromosome location	human chr5q34	25	3	26134	50	GABRA1,GABRA6,GABRB2
1.479e-05	-11.12	secretion by cell	biological process	GO:0032940	420	8	18204	49	PCLO,RIMS4,SMPD3,RIMS2,NRXN1,UNC13C,STXBP5L,CPLX1
1.530e-05	-11.09	postsynaptic density	cellular component	GO:0014069	317	7	19108	49	GRID2,GRIN2A,CACNA1C,PCLO,DLG3,LRRC7,INSYN1
1.569e-05	-11.06	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	43	16828	48	RGS7,RIMS2,ST8SIA5,GABRB2,R3HDM1,GABRD,MYT1L,OLFM1,AK5,RIMS4,CACNA1C,DLG3,NRXN3,GRID2,RYR2,CR2,STXBP5L,KSR2,RBFOX1,OPRL1,TTC9B,CELF6,SLC24A4,GABBR2,ZNF804A,GABRA1,KCNMA1,PTPRG,PCLO,CELF5,HCN1,LRRC7,PPP2R5B,NRXN1,UNC13C,GRIN2A,ZFPM2,CELF4,ASTN1,KCNT1,SMPD3,TRPM3,GABRA6
1.569e-05	-11.06	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	43	16828	48	SMPD3,TRPM3,GABRA6,ASTN1,KCNT1,LRRC7,PPP2R5B,NRXN1,GRIN2A,UNC13C,ZFPM2,CELF4,GABRA1,KCNMA1,PTPRG,PCLO,HCN1,CELF5,STXBP5L,CR2,KSR2,RBFOX1,OPRL1,CELF6,TTC9B,SLC24A4,GABBR2,ZNF804A,DLG3,NRXN3,RYR2,GRID2,MYT1L,OLFM1,GABRD,AK5,RIMS4,CACNA1C,RGS7,RIMS2,ST8SIA5,GABRB2,R3HDM1
1.576e-05	-11.06	calcium channel activity	molecular function	GO:0005262	117	5	18094	49	CACNA1C,TRPM3,GRIN2A,SLC24A4,RYR2
1.661e-05	-11.01	establishment of localization	biological process	GO:0051234	3887	24	18204	49	SLC24A4,RIMS4,RYR2,GABRA1,KCNIP4,SMPD3,GABRA6,LRRC7,RBFOX1,RIMS2,GABRD,TRPM3,PCLO,KCNMA1,KCNT1,GRIN2A,GRID2,STXBP5L,CACNA1C,UNC13C,CPLX1,HCN1,GABRB2,NRXN1
1.674e-05	-11.00	postsynaptic specialization membrane	cellular component	GO:0099634	125	5	19108	49	CACNA1C,GABRB2,DLG3,GRID2,GRIN2A
1.891e-05	-10.88	protein localization to synapse	biological process	GO:0035418	59	4	18204	49	LRRC7,PCLO,GRIN2A,NRXN1
1.897e-05	-10.87	NLGN2 (neuroligin 2)	protein interactions	57555	63	4	19454	49	ST8SIA5,NRXN1,DLG3,NRXN3
1.921e-05	-10.86	Morphine addiction	KEGG pathways	hsa05032	91	5	7161	27	GABRA1,GABRA6,GABRB2,GABRD,GABBR2
1.921e-05	-10.86	Morphine addiction	KEGG pathways	ko05032	91	5	7161	27	GABRD,GABRB2,GABRA6,GABRA1,GABBR2
2.100e-05	-10.77	asymmetric synapse	cellular component	GO:0032279	333	7	19108	49	INSYN1,LRRC7,CACNA1C,PCLO,DLG3,GRIN2A,GRID2
2.126e-05	-10.76	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	33	16828	48	CACNA1C,OLFM1,MYT1L,AK5,RBFOX3,RGS7,RIMS2,ST8SIA5,GABRB2,OPRL1,SLC24A4,ZNF804A,GABBR2,CR2,STXBP5L,KSR2,GRID2,RYR2,NRXN3,GRIN2A,UNC13C,ZFPM2,CELF4,LRRC7,NRXN1,PTPRG,PCLO,HCN1,GABRA1,KCNMA1,TRPM3,KCNT1,ASTN1
2.139e-05	-10.75	RBFOX1-like	interpro domains	IPR047131	3	2	18521	50	RBFOX1,RBFOX3
2.139e-05	-10.75	Fox-1_C_dom	interpro domains	IPR025670	3	2	18521	50	RBFOX3,RBFOX1
2.139e-05	-10.75	FOX1_RRM	interpro domains	IPR034237	3	2	18521	50	RBFOX3,RBFOX1
2.139e-05	-10.75	RBFOX1-3	interpro domains	IPR017325	3	2	18521	50	RBFOX1,RBFOX3
2.224e-05	-10.71	Fox-1_C	pfam domains	PF12414	3	2	17795	49	RBFOX3,RBFOX1
2.402e-05	-10.64	lower_third	COSMIC cancer mutations	lower_third	7961	37	16828	48	IL1RAPL2,GABRA1,KCNMA1,PCLO,CELF5,HCN1,PTPRG,PPP2R5B,NRXN1,LRRC7,CELF4,GRIN2A,UNC13C,ZFPM2,ASTN1,GALNT9,KCNT1,TRPM3,GABRA6,GABRB2,RIMS2,AK5,GABRD,MYT1L,CACNA1C,NRXN3,GRID2,RYR2,RBFOX1,KSR2,STXBP5L,CR2,ZNF804A,GABBR2,KCNIP4,SLC24A4,OPRL1
2.421e-05	-10.63	dendrite	cellular component	GO:0030425	620	9	19108	49	GABRA1,ZNF804A,KCNIP4,GABRD,CACNA1C,GRIN2A,GRID2,GABRA6,HCN1
2.422e-05	-10.63	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	18	16828	48	NRXN3,RYR2,TRPM3,STXBP5L,SLC24A4,RGS7,IL1RAPL2,GABRA1,HCN1,PCLO,PTPRG,PPP2R5B,MYT1L,OLFM1,CACNA1C,RIMS4,GRIN2A,UNC13C
2.478e-05	-10.61	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	9	18094	49	CACNA1C,GRIN2A,SLC24A4,RYR2,KCNT1,TRPM3,KCNIP4,KCNMA1,HCN1
2.483e-05	-10.60	dendritic tree	cellular component	GO:0097447	622	9	19108	49	GRID2,GRIN2A,HCN1,GABRA6,GABRA1,KCNIP4,ZNF804A,CACNA1C,GABRD
2.743e-05	-10.50	regulation of mRNA processing	biological process	GO:0050684	132	5	18204	49	CELF4,RBFOX3,CELF6,RBFOX1,CELF5
2.938e-05	-10.44	Protein-protein interactions at synapses	REACTOME pathways	R-HSA-6794362	72	4	10285	26	DLG3,GRIN2A,NRXN3,NRXN1
3.048e-05	-10.40	DNAJC18 (DnaJ heat shock protein family (Hsp40) member C18)	protein interactions	202052	71	4	19454	49	MARCHF4,GABRA6,GRIN2A,GABRD
3.115e-05	-10.38	neuronal cell body	cellular component	GO:0043025	489	8	19108	49	ZNF804A,KCNIP4,CACNA1C,GABRD,NRXN1,OLFM1,ASTN1,CPLX1
3.125e-05	-10.37	inhibitory synapse assembly	biological process	GO:1904862	23	3	18204	49	GABRA1,GABRA6,GABRB2
3.145e-05	-10.37	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	5	18094	49	GRIN2A,RYR2,HCN1,KCNT1,KCNMA1
3.188e-05	-10.35	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	5	7161	27	GABRD,GABRB2,GABRA6,CACNA1C,GABRA1
3.188e-05	-10.35	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	5	7161	27	GABRA6,CACNA1C,GABRA1,GABRD,GABRB2
3.258e-05	-10.33	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	5	18094	49	GRIN2A,SLC24A4,RYR2,CACNA1C,TRPM3
3.445e-05	-10.28	inorganic cation transmembrane transport	biological process	GO:0098662	618	9	18204	49	HCN1,CACNA1C,KCNMA1,GRIN2A,KCNIP4,KCNT1,RYR2,SLC24A4,TRPM3
3.588e-05	-10.24	Ligand-gated ion channel transport	REACTOME pathways	R-HSA-975298	26	3	10285	26	GABRA6,GABRA1,GABRB2
3.773e-05	-10.19	neuron to neuron synapse	cellular component	GO:0098984	365	7	19108	49	GRIN2A,GRID2,DLG3,PCLO,CACNA1C,INSYN1,LRRC7
3.942e-05	-10.14	peptide hormone secretion	biological process	GO:0030072	71	4	18204	49	PCLO,RIMS2,CPLX1,SMPD3
3.946e-05	-10.14	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	25	16828	48	ASTN1,PCLO,CELF5,HCN1,PTPRG,IL1RAPL2,GABRA1,KCNMA1,CELF4,UNC13C,GRIN2A,ZFPM2,LRRC7,GRID2,RYR2,NRXN3,ZNF804A,GABBR2,KSR2,STXBP5L,R3HDM1,ST8SIA5,RIMS2,CACNA1C,AK5
4.003e-05	-10.13	metal ion transport	biological process	GO:0030001	630	9	18204	49	GRIN2A,KCNT1,KCNIP4,RYR2,HCN1,CACNA1C,KCNMA1,TRPM3,SLC24A4
4.145e-05	-10.09	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	23	16828	48	R3HDM1,ST8SIA5,CACNA1C,AK5,GRID2,RYR2,NRXN3,ZNF804A,GABBR2,STXBP5L,KSR2,PTPRG,PCLO,HCN1,CELF5,GABRA1,IL1RAPL2,UNC13C,GRIN2A,ZFPM2,CELF4,LRRC7,ASTN1
4.163e-05	-10.09	synaptic vesicle cycle	biological process	GO:0099504	144	5	18204	49	RIMS2,PCLO,RIMS4,CPLX1,UNC13C
4.163e-05	-10.09	regulated exocytosis	biological process	GO:0045055	144	5	18204	49	CPLX1,UNC13C,RIMS2,PCLO,RIMS4
4.195e-05	-10.08	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	9	18094	49	HCN1,KCNMA1,KCNIP4,TRPM3,RYR2,KCNT1,SLC24A4,GRIN2A,CACNA1C
4.271e-05	-10.06	K_chnl_Slo-like	interpro domains	IPR047871	4	2	18521	50	KCNT1,KCNMA1
4.271e-05	-10.06	Rim-like	interpro domains	IPR039032	4	2	18521	50	RIMS2,RIMS4
4.271e-05	-10.06	K_chnl_BK_asu	interpro domains	IPR003929	4	2	18521	50	KCNT1,KCNMA1
4.309e-05	-10.05	monoatomic cation transmembrane transport	biological process	GO:0098655	636	9	18204	49	TRPM3,SLC24A4,KCNIP4,KCNT1,GRIN2A,RYR2,CACNA1C,HCN1,KCNMA1
4.394e-05	-10.03	exocytosis	biological process	GO:0006887	241	6	18204	49	RIMS2,STXBP5L,UNC13C,CPLX1,RIMS4,PCLO
4.399e-05	-10.03	chemical synaptic transmission, postsynaptic	biological process	GO:0099565	73	4	18204	49	GRIN2A,INSYN1,CELF4,GRID2
4.441e-05	-10.02	BK_channel_a	pfam domains	PF03493	4	2	17795	49	KCNT1,KCNMA1
4.527e-05	-10.00	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	6	16828	48	PCLO,HCN1,RIMS2,CACNA1C,MYT1L,OLFM1
4.711e-05	-9.96	modulation of chemical synaptic transmission	biological process	GO:0050804	494	8	18204	49	CELF4,GRIN2A,RIMS2,NRXN1,UNC13C,CPLX1,RIMS4,GRID2
4.735e-05	-9.96	GABA-ergic synapse	cellular component	GO:0098982	78	4	19108	49	GABRA1,GABRB2,PCLO,GABRD
4.778e-05	-9.95	regulation of trans-synaptic signaling	biological process	GO:0099177	495	8	18204	49	RIMS4,GRID2,RIMS2,NRXN1,CELF4,GRIN2A,UNC13C,CPLX1
4.893e-05	-9.93	peptide secretion	biological process	GO:0002790	75	4	18204	49	CPLX1,SMPD3,PCLO,RIMS2
5.734e-05	-9.77	calcium-mediated signaling	biological process	GO:0019722	154	5	18204	49	CACNA1C,KSR2,RYR2,OPRL1,GRIN2A
5.734e-05	-9.77	vesicle-mediated transport in synapse	biological process	GO:0099003	154	5	18204	49	CPLX1,UNC13C,RIMS2,PCLO,RIMS4
5.800e-05	-9.76	localization	biological process	GO:0051179	4474	25	18204	49	SMPD3,GABRA6,LRRC7,RBFOX1,RIMS2,GABRD,SLC24A4,RIMS4,GABRA1,RYR2,KCNIP4,GRID2,HCN1,CPLX1,GABRB2,UNC13C,STXBP5L,CACNA1C,NRXN1,PCLO,TRPM3,KCNMA1,DLG3,GRIN2A,KCNT1
5.891e-05	-9.74	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	14	16828	48	STXBP5L,AK5,KSR2,ZFPM2,UNC13C,GRIN2A,CELF4,IL1RAPL2,ASTN1,NRXN3,PTPRG,HCN1,GRID2,RYR2
5.891e-05	-9.74	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	14	16828	48	HCN1,PTPRG,IL1RAPL2,CELF4,GRIN2A,UNC13C,ZFPM2,AK5,GRID2,RYR2,NRXN3,ASTN1,KSR2,STXBP5L
6.028e-05	-9.72	thyroid	COSMIC cancer mutations	thyroid	9867	41	16828	48	ASTN1,GALNT9,KCNT1,TRPM3,SMPD3,GABRA6,GABRA1,KCNMA1,PCLO,CELF5,HCN1,PTPRG,NRXN1,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,NRXN3,DLG3,GRID2,RYR2,KSR2,RBFOX1,STXBP5L,CR2,GABBR2,KCNIP4,ZNF804A,OPRL1,CELF6,TTC9B,ST8SIA5,RBFOX3,RIMS2,R3HDM1,MYT1L,OLFM1,GABRD,CACNA1C,RIMS4
6.082e-05	-9.71	alveolar	COSMIC cancer mutations	alveolar	2414	18	16828	48	ZFPM2,GRIN2A,MYT1L,LRRC7,HCN1,PCLO,R3HDM1,PTPRG,GABBR2,ZNF804A,GABRA6,RBFOX1,TRPM3,STXBP5L,RYR2,GRID2,KCNT1,ASTN1
6.082e-05	-9.71	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	18	16828	48	LRRC7,MYT1L,ZFPM2,GRIN2A,PTPRG,HCN1,R3HDM1,PCLO,STXBP5L,RBFOX1,TRPM3,GABRA6,ZNF804A,GABBR2,ASTN1,KCNT1,RYR2,GRID2
6.664e-05	-9.62	potassium ion transmembrane transporter activity	molecular function	GO:0015079	158	5	18094	49	KCNIP4,KCNMA1,HCN1,SLC24A4,KCNT1
6.774e-05	-9.60	chloride channel activity	molecular function	GO:0005254	81	4	18094	49	GABRD,GABRA6,GABRB2,GABRA1
7.147e-05	-9.55	neuroligin family protein binding	molecular function	GO:0097109	5	2	18094	49	NRXN3,NRXN1
7.281e-05	-9.53	peptide transport	biological process	GO:0015833	83	4	18204	49	PCLO,RIMS2,CPLX1,SMPD3
7.700e-05	-9.47	cell body	cellular component	GO:0044297	556	8	19108	49	CPLX1,ASTN1,OLFM1,NRXN1,CACNA1C,GABRD,ZNF804A,KCNIP4
7.827e-05	-9.46	multicellular organism development	biological process	GO:0007275	3957	23	18204	49	IL1RAPL2,RBFOX1,LRRC7,SMPD3,GABRA6,RYR2,GABRA1,RBFOX3,SLC24A4,NRXN1,CACNA1C,HCN1,GABRB2,OLFM1,GRID2,NRXN3,DLG3,GRIN2A,CELF4,ZFPM2,ASTN1,MYT1L,PCLO
7.954e-05	-9.44	potassium ion transmembrane transport	biological process	GO:0071805	165	5	18204	49	KCNIP4,KCNT1,KCNMA1,SLC24A4,HCN1
8.097e-05	-9.42	glutamatergic synapse	cellular component	GO:0098978	412	7	19108	49	IL1RAPL2,PCLO,DLG3,GRID2,GRIN2A,CPLX1,HCN1
8.332e-05	-9.39	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	12	16828	48	GABBR2,ZNF804A,CELF4,ZFPM2,GRIN2A,KSR2,STXBP5L,HCN1,GRID2,PTPRG,GALNT9,IL1RAPL2
8.332e-05	-9.39	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	12	16828	48	GALNT9,IL1RAPL2,PTPRG,HCN1,GRID2,STXBP5L,KSR2,ZFPM2,GRIN2A,ZNF804A,GABBR2,CELF4
8.347e-05	-9.39	secretion	biological process	GO:0046903	536	8	18204	49	RIMS4,PCLO,SMPD3,RIMS2,NRXN1,STXBP5L,UNC13C,CPLX1
8.364e-05	-9.39	protein localization to cell junction	biological process	GO:1902414	86	4	18204	49	LRRC7,PCLO,GRIN2A,NRXN1
8.604e-05	-9.36	positive regulation of excitatory postsynaptic potential	biological process	GO:2000463	32	3	18204	49	RIMS2,NRXN1,GRIN2A
9.415e-05	-9.27	regulation of exocytosis	biological process	GO:0017157	171	5	18204	49	SMPD3,CPLX1,RIMS2,RIMS4,PCLO
9.685e-05	-9.24	voltage-gated monoatomic ion channel activity	molecular function	GO:0005244	171	5	18094	49	CACNA1C,GRIN2A,KCNMA1,KCNT1,HCN1
1.004e-04	-9.21	femur	COSMIC cancer mutations	femur	1197	12	16828	48	LRRC7,GABRD,GRIN2A,PTPRG,HCN1,STXBP5L,SMPD3,GABRA6,GABBR2,ZNF804A,NRXN3,GRID2
1.023e-04	-9.19	voltage-gated channel activity	molecular function	GO:0022832	173	5	18094	49	CACNA1C,KCNT1,HCN1,KCNMA1,GRIN2A
1.064e-04	-9.15	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	2	18521	50	NRXN3,NRXN1
1.064e-04	-9.15	Gabra-1-6_TM	interpro domains	IPR047024	6	2	18521	50	GABRA6,GABRA1
1.064e-04	-9.15	GABAAa_rcpt	interpro domains	IPR001390	6	2	18521	50	GABRA1,GABRA6
1.073e-04	-9.14	molecular transducer activity	molecular function	GO:0060089	1474	13	18094	49	GRID2,NRXN1,CR2,OPRL1,GABRD,GABRA6,GABRA1,GRIN2A,IL1RAPL2,NRXN3,GABBR2,GABRB2,PTPRG
1.073e-04	-9.14	signaling receptor activity	molecular function	GO:0038023	1474	13	18094	49	IL1RAPL2,GABBR2,PTPRG,GRID2,CR2,NRXN3,GABRB2,NRXN1,OPRL1,GABRD,GRIN2A,GABRA6,GABRA1
1.078e-04	-9.13	potassium ion transport	biological process	GO:0006813	176	5	18204	49	KCNMA1,HCN1,SLC24A4,KCNT1,KCNIP4
1.088e-04	-9.13	hormone secretion	biological process	GO:0046879	92	4	18204	49	CPLX1,SMPD3,PCLO,RIMS2
1.104e-04	-9.11	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	12	16828	48	GABRA6,GRID2,RYR2,NRXN3,ZFPM2,UNC13C,PCLO,PTPRG,GABRB2,RIMS2,IL1RAPL2,RGS7
1.106e-04	-9.11	Syndecan	pfam domains	PF01034	6	2	17795	49	NRXN1,NRXN3
1.110e-04	-9.11	cell junction assembly	biological process	GO:0034329	285	6	18204	49	GRID2,GABRA6,GABRB2,NRXN1,GABRA1,PCLO
1.176e-04	-9.05	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	24	16828	48	CACNA1C,MYT1L,RIMS2,KCNIP4,ZNF804A,OPRL1,TTC9B,KSR2,CR2,STXBP5L,RYR2,GRID2,NRXN3,GRIN2A,ZFPM2,NRXN1,LRRC7,PCLO,CELF5,HCN1,KCNMA1,GABRA6,TRPM3,ASTN1
1.191e-04	-9.04	ST7L (suppression of tumorigenicity 7 like)	protein interactions	54879	38	3	19454	49	GABRD,GABRA6,MARCHF4
1.200e-04	-9.03	nervous system development	biological process	GO:0007399	2185	16	18204	49	ASTN1,GRIN2A,GABRA1,SLC24A4,PCLO,RBFOX3,MYT1L,GABRB2,HCN1,RBFOX1,IL1RAPL2,NRXN1,NRXN3,GABRA6,OLFM1,GRID2
1.232e-04	-9.00	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	4	18204	49	GRIN2A,RYR2,SLC24A4,CACNA1C
1.298e-04	-8.95	postsynaptic density membrane	cellular component	GO:0098839	101	4	19108	49	GRIN2A,GRID2,CACNA1C,DLG3
1.306e-04	-8.94	plasma membrane protein complex	cellular component	GO:0098797	600	8	19108	49	HCN1,GRID2,GRIN2A,CACNA1C,DLG3,KCNIP4,KCNMA1,GABBR2
1.313e-04	-8.94	monoatomic anion channel activity	molecular function	GO:0005253	96	4	18094	49	GABRD,GABRA6,GABRB2,GABRA1
1.348e-04	-8.91	ANF_lig-bd_rcpt	interpro domains	IPR001828	37	3	18521	50	GRID2,GRIN2A,GABBR2
1.363e-04	-8.90	regulation of RNA splicing	biological process	GO:0043484	185	5	18204	49	CELF4,RBFOX3,CELF5,RBFOX1,CELF6
1.427e-04	-8.85	ANF_receptor	pfam domains	PF01094	37	3	17795	49	GABBR2,GRID2,GRIN2A
1.447e-04	-8.84	mRNA splice site recognition	biological process	GO:0006376	38	3	18204	49	CELF5,CELF6,CELF4
1.534e-04	-8.78	Ion channel transport	REACTOME pathways	R-HSA-983712	209	5	10285	26	TRPM3,GABRB2,GABRA6,GABRA1,RYR2
1.577e-04	-8.75	ionotropic glutamate receptor complex	cellular component	GO:0008328	41	3	19108	49	GRID2,GRIN2A,DLG3
1.580e-04	-8.75	Peripla_BP_I	interpro domains	IPR028082	39	3	18521	50	GABBR2,GRIN2A,GRID2
1.684e-04	-8.69	hormone transport	biological process	GO:0009914	103	4	18204	49	SMPD3,CPLX1,RIMS2,PCLO
1.759e-04	-8.65	cation channel complex	cellular component	GO:0034703	205	5	19108	49	KCNMA1,RYR2,CACNA1C,HCN1,KCNIP4
1.785e-04	-8.63	monoatomic cation transport	biological process	GO:0006812	766	9	18204	49	HCN1,CACNA1C,KCNMA1,GRIN2A,KCNIP4,KCNT1,RYR2,SLC24A4,TRPM3
1.805e-04	-8.62	adenoma	COSMIC cancer mutations	adenoma	2873	19	16828	48	GABRB2,KCNMA1,RIMS2,HCN1,PCLO,OLFM1,MYT1L,LRRC7,CACNA1C,UNC13C,ASTN1,NRXN3,GRID2,RBFOX1,TRPM3,CR2,GABBR2,GABRA6,OPRL1
1.862e-04	-8.59	GABAARALPHA	prints domains	PR01079	6	2	5227	19	GABRA6,GABRA1
1.865e-04	-8.59	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	18	16828	48	STXBP5L,TRPM3,SLC24A4,NRXN3,RYR2,OLFM1,MYT1L,PPP2R5B,RIMS4,GRIN2A,UNC13C,CACNA1C,IL1RAPL2,GABRA1,RGS7,PTPRG,HCN1,PCLO
1.989e-04	-8.52	ligand-gated monoatomic anion channel activity	molecular function	GO:0099095	42	3	18094	49	GABRB2,GABRA1,GABRA6
2.047e-04	-8.49	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	18	16828	48	GRID2,RYR2,KCNT1,NRXN3,ZNF804A,KSR2,RBFOX1,CR2,STXBP5L,HCN1,R3HDM1,PTPRG,RIMS2,RBFOX3,CACNA1C,ZFPM2,NRXN1,MYT1L
2.053e-04	-8.49	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	12	16828	48	KCNT1,CELF5,HCN1,GRID2,GABRA1,RGS7,ASTN1,GABRA6,GRIN2A,GABBR2,CR2,RBFOX1
2.127e-04	-8.46	RRM_1	pfam domains	PF00076	199	5	17795	49	CELF4,RBFOX1,CELF6,CELF5,RBFOX3
2.169e-04	-8.44	chloride transmembrane transport	biological process	GO:1902476	110	4	18204	49	GABRA1,GABRD,GABRA6,GABRB2
2.199e-04	-8.42	calcium ion transmembrane transport	biological process	GO:0070588	205	5	18204	49	CACNA1C,SLC24A4,RYR2,GRIN2A,TRPM3
2.215e-04	-8.42	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	15	16828	48	NRXN3,RYR2,GRID2,CR2,STXBP5L,KSR2,KCNMA1,RIMS2,HCN1,PCLO,LRRC7,NRXN1,GRIN2A,UNC13C,CACNA1C
2.226e-04	-8.41	neurotransmitter receptor complex	cellular component	GO:0098878	46	3	19108	49	GRID2,GRIN2A,DLG3
2.241e-04	-8.40	larynx	COSMIC cancer mutations	larynx	1948	15	16828	48	KSR2,CR2,STXBP5L,NRXN3,GRID2,RYR2,NRXN1,LRRC7,CACNA1C,GRIN2A,UNC13C,KCNMA1,RIMS2,PCLO,HCN1
2.246e-04	-8.40	synaptic transmission, glutamatergic	biological process	GO:0035249	44	3	18204	49	UNC13C,GRID2,GRIN2A
2.257e-04	-8.40	axon	cellular component	GO:0030424	650	8	19108	49	UNC13C,ZNF804A,PCLO,GABRD,LRRC7,HCN1,OLFM1,CPLX1
2.292e-04	-8.38	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	29	16828	48	RYR2,GRID2,NRXN3,GABBR2,ZNF804A,STXBP5L,CR2,RBFOX1,KSR2,R3HDM1,RBFOX3,RIMS2,GABRB2,CACNA1C,MYT1L,AK5,KCNT1,ASTN1,GABRA6,TRPM3,PTPRG,PCLO,HCN1,IL1RAPL2,GRIN2A,UNC13C,ZFPM2,CELF4,LRRC7
2.294e-04	-8.38	Taste transduction	KEGG pathways	ko04742	82	4	7161	27	GABBR2,CACNA1C,GABRA1,GABRA6
2.294e-04	-8.38	Taste transduction	KEGG pathways	hsa04742	82	4	7161	27	GABBR2,GABRA1,CACNA1C,GABRA6
2.320e-04	-8.37	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	12	16828	48	GRIN2A,OLFM1,RGS7,GABRA6,OPRL1,SLC24A4,ZNF804A,CR2,SMPD3,TRPM3,GRID2,NRXN3
2.565e-04	-8.27	receptor clustering	biological process	GO:0043113	46	3	18204	49	NRXN1,DLG3,LRRC7
2.582e-04	-8.26	synapse organization	biological process	GO:0050808	333	6	18204	49	NRXN1,GABRA1,PCLO,GRID2,GABRA6,GABRB2
2.728e-04	-8.21	arm	COSMIC cancer mutations	arm	1331	12	16828	48	TRPM3,CR2,SMPD3,ZNF804A,SLC24A4,GABRA6,OPRL1,NRXN3,GRID2,OLFM1,GRIN2A,RGS7
2.788e-04	-8.19	RRM_dom	interpro domains	IPR000504	215	5	18521	50	RBFOX1,CELF5,CELF6,CELF4,RBFOX3
2.875e-04	-8.15	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	21	16828	48	CACNA1C,CELF4,GRIN2A,UNC13C,AK5,LRRC7,MYT1L,CELF5,HCN1,PCLO,PTPRG,RIMS2,GABRA1,ZNF804A,OPRL1,TRPM3,KSR2,GRID2,RYR2,ASTN1,NRXN3
2.904e-04	-8.14	membrane	cellular component	GO:0016020	9220	36	19108	49	RYR2,ASTN1,GABRA6,SMPD3,PTPRG,KSR2,NRXN1,LRRC7,NRXN3,GRIN2A,MARCHF4,TRPM3,STXBP5L,RIMS2,KCNMA1,ZNF804A,UNC13C,KCNIP4,GABRB2,ST8SIA5,CACNA1C,GRID2,CR2,CPLX1,RIMS4,GABBR2,IL1RAPL2,KCNT1,GALNT9,HCN1,GABRA1,RGS7,DLG3,OPRL1,GABRD,SLC24A4
2.911e-04	-8.14	insulin secretion	biological process	GO:0030073	48	3	18204	49	CPLX1,RIMS2,PCLO
2.911e-04	-8.14	calcium-ion regulated exocytosis	biological process	GO:0017156	48	3	18204	49	RIMS2,RIMS4,UNC13C
2.984e-04	-8.12	regulation of synaptic plasticity	biological process	GO:0048167	219	5	18204	49	GRIN2A,RIMS4,RIMS2,UNC13C,GRID2
2.998e-04	-8.11	chloride transmembrane transporter activity	molecular function	GO:0015108	119	4	18094	49	GABRD,GABRA6,GABRB2,GABRA1
3.026e-04	-8.10	regulation of nervous system process	biological process	GO:0031644	120	4	18204	49	GRIN2A,CELF4,NRXN1,RIMS2
3.032e-04	-8.10	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	44	16828	48	TRPM3,SMPD3,GABRA6,ASTN1,KCNT1,NRXN1,PPP2R5B,LRRC7,CELF4,ZFPM2,GRIN2A,UNC13C,KCNMA1,GABRA1,IL1RAPL2,HCN1,CELF5,PCLO,PTPRG,KSR2,RBFOX1,STXBP5L,CR2,ZNF804A,SLC24A4,GABBR2,TTC9B,CELF6,OPRL1,NRXN3,DLG3,GRID2,RYR2,AK5,MYT1L,GABRD,CPLX1,CACNA1C,RIMS4,GABRB2,ST8SIA5,RIMS2,RGS7,R3HDM1
3.056e-04	-8.09	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-follicular_lymphoma	208	5	16828	48	RIMS2,RGS7,GRID2,PCLO,UNC13C
3.069e-04	-8.09	cervix	COSMIC cancer mutations	cervix	11793	44	16828	48	R3HDM1,RIMS2,ST8SIA5,GABRB2,RIMS4,CPLX1,GABRD,MYT1L,AK5,DLG3,NRXN3,CELF6,TTC9B,GABBR2,STXBP5L,RBFOX1,CELF5,GABRA1,IL1RAPL2,GRIN2A,UNC13C,ZFPM2,CELF4,LRRC7,TRPM3,RGS7,CACNA1C,RYR2,GRID2,OPRL1,ZNF804A,SLC24A4,CR2,KSR2,PTPRG,PCLO,HCN1,KCNMA1,PPP2R5B,NRXN1,KCNT1,ASTN1,GABRA6,SMPD3
3.123e-04	-8.07	chloride transport	biological process	GO:0006821	121	4	18204	49	GABRB2,GABRA6,GABRA1,GABRD
3.297e-04	-8.02	potassium channel activity	molecular function	GO:0005267	122	4	18094	49	KCNMA1,KCNT1,HCN1,KCNIP4
3.369e-04	-8.00	CELF3 (CUGBP Elav-like family member 3)	protein interactions	11189	11	2	19454	49	RBFOX1,CELF5
3.510e-04	-7.95	PDZ	pfam domains	PF00595	122	4	17795	49	DLG3,PCLO,LRRC7,RIMS2
3.569e-04	-7.94	functioning	COSMIC cancer mutations	functioning	1803	14	16828	48	RIMS4,UNC13C,GRIN2A,MYT1L,OLFM1,PTPRG,HCN1,PCLO,IL1RAPL2,SLC24A4,STXBP5L,TRPM3,RYR2,NRXN3
3.569e-04	-7.94	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	14	16828	48	RYR2,NRXN3,SLC24A4,TRPM3,STXBP5L,PCLO,HCN1,PTPRG,IL1RAPL2,GRIN2A,UNC13C,RIMS4,MYT1L,OLFM1
3.621e-04	-7.92	C2	pfam domains	PF00168	123	4	17795	49	PCLO,RIMS4,UNC13C,RIMS2
3.890e-04	-7.85	benzodiazepine receptor activity	molecular function	GO:0008503	11	2	18094	49	GABRA6,GABRA1
3.944e-04	-7.84	RRM	prosite domains	PS50102	209	5	12186	37	RBFOX3,CELF5,RBFOX1,CELF6,CELF4
4.186e-04	-7.78	transmembrane signaling receptor activity	molecular function	GO:0004888	1251	11	18094	49	CR2,GRID2,PTPRG,GABBR2,IL1RAPL2,GABRA6,GABRA1,GRIN2A,GABRD,OPRL1,GABRB2
4.347e-04	-7.74	inorganic anion transmembrane transport	biological process	GO:0098661	132	4	18204	49	GABRA1,GABRD,GABRA6,GABRB2
4.462e-04	-7.71	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	13	16828	48	KSR2,ZNF804A,CELF6,GABRA6,NRXN3,DLG3,RYR2,GRID2,KCNT1,LRRC7,ZFPM2,IL1RAPL2,RIMS2
4.462e-04	-7.71	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	13	16828	48	NRXN3,DLG3,GRID2,RYR2,KCNT1,KSR2,ZNF804A,GABRA6,CELF6,RIMS2,IL1RAPL2,LRRC7,ZFPM2
4.504e-04	-7.71	system development	biological process	GO:0048731	3533	20	18204	49	NRXN1,IL1RAPL2,CACNA1C,RBFOX1,HCN1,GABRB2,GRID2,OLFM1,SMPD3,GABRA6,NRXN3,RYR2,GABRA1,GRIN2A,ZFPM2,ASTN1,MYT1L,RBFOX3,PCLO,SLC24A4
4.605e-04	-7.68	regulation of ventricular cardiac muscle cell action potential	biological process	GO:0098911	12	2	18204	49	RYR2,CACNA1C
4.794e-04	-7.64	RBD_domain_sf	interpro domains	IPR035979	242	5	18521	50	CELF6,RBFOX3,CELF4,RBFOX1,CELF5
5.070e-04	-7.59	Nucleotide-bd_a/b_plait_sf	interpro domains	IPR012677	245	5	18521	50	RBFOX1,CELF5,CELF6,CELF4,RBFOX3
5.116e-04	-7.58	DLG2 (discs large MAGUK scaffold protein 2)	protein interactions	1740	62	3	19454	49	GRIN2A,GRID2,DLG3
5.271e-04	-7.55	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	23	16828	48	KCNT1,ASTN1,GABRA6,TRPM3,PTPRG,PCLO,HCN1,UNC13C,GRIN2A,ZFPM2,LRRC7,RYR2,GRID2,ZNF804A,GABBR2,CR2,STXBP5L,RBFOX1,R3HDM1,RIMS2,GABRB2,CACNA1C,MYT1L
5.286e-04	-7.55	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	11	16828	48	ASTN1,RIMS2,IL1RAPL2,GRID2,AK5,TRPM3,SMPD3,CR2,ZNF804A,GABRA6,GRIN2A
5.368e-04	-7.53	scalp	COSMIC cancer mutations	scalp	2110	15	16828	48	GRID2,KCNT1,ASTN1,NRXN3,GABBR2,GABRA6,OPRL1,CR2,SMPD3,STXBP5L,RIMS2,GRIN2A,NRXN1,LRRC7,OLFM1
5.432e-04	-7.52	calcium ion transport into cytosol	biological process	GO:0060402	13	2	18204	49	CACNA1C,RYR2
5.459e-04	-7.51	RRM	smart domains	SM00360	202	5	9717	33	CELF6,CELF4,CELF5,RBFOX3,RBFOX1
5.566e-04	-7.49	calcium ion transport	biological process	GO:0006816	251	5	18204	49	CACNA1C,SLC24A4,RYR2,TRPM3,GRIN2A
5.586e-04	-7.49	neck	COSMIC cancer mutations	neck	1231	11	16828	48	GRID2,ASTN1,IL1RAPL2,RIMS2,ZNF804A,GRIN2A,GABRA6,TRPM3,AK5,SMPD3,CR2
5.656e-04	-7.48	-	gene3d domains	3.40.50.2300	50	3	14470	47	GRIN2A,GRID2,GABBR2
5.676e-04	-7.47	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	12	16828	48	LRRC7,MYT1L,NRXN1,UNC13C,CACNA1C,GABRA1,PCLO,STXBP5L,TRPM3,GABRA6,ASTN1,RYR2
5.726e-04	-7.47	monoatomic anion transmembrane transport	biological process	GO:0098656	142	4	18204	49	GABRB2,GABRA6,GABRA1,GABRD
5.730e-04	-7.46	syntaxin binding	molecular function	GO:0019905	60	3	18094	49	UNC13C,CPLX1,STXBP5L
5.857e-04	-7.44	monoatomic anion transmembrane transporter activity	molecular function	GO:0008509	142	4	18094	49	GABRA6,GABRA1,GABRB2,GABRD
5.957e-04	-7.43	C2_dom	interpro domains	IPR000008	143	4	18521	50	UNC13C,RIMS2,RIMS4,PCLO
6.014e-04	-7.42	voltage-gated monoatomic cation channel activity	molecular function	GO:0022843	143	4	18094	49	HCN1,KCNT1,KCNMA1,CACNA1C
6.023e-04	-7.41	perikaryon	cellular component	GO:0043204	151	4	19108	49	OLFM1,ASTN1,CACNA1C,CPLX1
6.035e-04	-7.41	amide transport	biological process	GO:0042886	144	4	18204	49	PCLO,RIMS2,CPLX1,SMPD3
6.327e-04	-7.37	response to redox state	biological process	GO:0051775	14	2	18204	49	SMPD3,RYR2
6.366e-04	-7.36	Neurexin-like	interpro domains	IPR003585	14	2	18521	50	NRXN3,NRXN1
6.440e-04	-7.35	PDZ	interpro domains	IPR001478	146	4	18521	50	RIMS2,PCLO,LRRC7,DLG3
6.532e-04	-7.33	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	46	16828	48	RBFOX1,STXBP5L,KCNIP4,GABBR2,CELF6,NRXN3,AK5,MYT1L,OLFM1,GABRD,CPLX1,RIMS4,ST8SIA5,GABRB2,RIMS2,R3HDM1,TRPM3,GALNT9,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,IL1RAPL2,GABRA1,CELF5,KSR2,CR2,SLC24A4,ZNF804A,OPRL1,RYR2,GRID2,CACNA1C,RGS7,RBFOX3,SMPD3,GABRA6,ASTN1,KCNT1,PPP2R5B,NRXN1,KCNMA1,PCLO,HCN1,PTPRG
6.950e-04	-7.27	PDZ_sf	interpro domains	IPR036034	149	4	18521	50	PCLO,RIMS2,DLG3,LRRC7
7.292e-04	-7.22	GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3)	protein interactions	2562	16	2	19454	49	GABRA6,GABRB2
7.303e-04	-7.22	C2	smart domains	SM00239	122	4	9717	33	PCLO,RIMS2,RIMS4,UNC13C
7.504e-04	-7.19	DLG4 (discs large MAGUK scaffold protein 4)	protein interactions	1742	163	4	19454	49	GRIN2A,DLG3,PTPRG,LRRC7
7.565e-04	-7.19	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	48	KSR2,RBFOX1,STXBP5L,CR2,SLC24A4,GABBR2,ZNF804A,OPRL1,CELF6,NRXN3,DLG3,GRID2,RYR2,AK5,MYT1L,OLFM1,GABRD,CACNA1C,RIMS4,ST8SIA5,RGS7,RIMS2,TRPM3,SMPD3,GABRA6,ASTN1,KCNT1,PPP2R5B,NRXN1,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,GABRA1,IL1RAPL2,KCNMA1,PCLO,CELF5,HCN1,PTPRG
7.762e-04	-7.16	learning	biological process	GO:0007612	154	4	18204	49	NRXN3,OPRL1,GRIN2A,NRXN1
7.778e-04	-7.16	excitatory postsynaptic potential	biological process	GO:0060079	67	3	18204	49	GRIN2A,CELF4,GRID2
7.926e-04	-7.14	GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A)	protein interactions	2903	72	3	19454	49	PPP2R5B,DLG3,GRIN2A
8.322e-04	-7.09	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	11	16828	48	ST8SIA5,RIMS2,PTPRG,MYT1L,ZFPM2,NRXN3,RYR2,KCNT1,RBFOX1,KSR2,SMPD3
8.342e-04	-7.09	positive regulation of synaptic transmission	biological process	GO:0050806	157	4	18204	49	GRIN2A,RIMS4,RIMS2,NRXN1
8.659e-04	-7.05	C2	prosite domains	PS50004	142	4	12186	37	RIMS4,UNC13C,RIMS2,PCLO
8.745e-04	-7.04	monoatomic anion transport	biological process	GO:0006820	159	4	18204	49	GABRA1,GABRD,GABRB2,GABRA6
8.826e-04	-7.03	nodular	COSMIC cancer mutations	nodular	1515	12	16828	48	GABRA1,RGS7,ASTN1,KCNT1,GRID2,CELF5,HCN1,CR2,RBFOX1,GRIN2A,GABRA6,GABBR2
8.889e-04	-7.03	PDZ	prosite domains	PS50106	143	4	12186	37	DLG3,PCLO,LRRC7,RIMS2
8.943e-04	-7.02	inorganic anion transmembrane transporter activity	molecular function	GO:0015103	159	4	18094	49	GABRB2,GABRA1,GABRA6,GABRD
9.162e-04	-7.00	inorganic anion transport	biological process	GO:0015698	161	4	18204	49	GABRD,GABRA1,GABRA6,GABRB2
9.267e-04	-6.98	GRIK5 (glutamate ionotropic receptor kainate type subunit 5)	protein interactions	2901	18	2	19454	49	GRID2,DLG3
9.407e-04	-6.97	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	2	18204	49	CACNA1C,RYR2
9.601e-04	-6.95	calyx of Held	cellular component	GO:0044305	18	2	19108	49	CPLX1,UNC13C
9.636e-04	-6.94	LITAF (lipopolysaccharide induced TNF factor)	protein interactions	9516	77	3	19454	49	KCNIP4,CACNA1C,R3HDM1
9.687e-04	-6.94	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	32	16828	48	RIMS4,CACNA1C,CPLX1,MYT1L,OLFM1,AK5,R3HDM1,RBFOX3,ST8SIA5,ZNF804A,KCNIP4,GABBR2,STXBP5L,KSR2,GRID2,RYR2,NRXN3,UNC13C,GRIN2A,ZFPM2,CELF4,LRRC7,PTPRG,PCLO,HCN1,CELF5,IL1RAPL2,GABRA1,GABRA6,KCNT1,GALNT9,ASTN1
9.910e-04	-6.92	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	21	16828	48	PTPRG,PCLO,HCN1,IL1RAPL2,RIMS2,GRIN2A,CELF4,CACNA1C,LRRC7,OLFM1,AK5,NRXN1,KCNT1,GRID2,RYR2,NRXN3,ASTN1,GABRA6,ZNF804A,GABBR2,KSR2
9.910e-04	-6.92	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	21	16828	48	ZNF804A,GABBR2,GABRA6,KSR2,RYR2,GRID2,KCNT1,ASTN1,NRXN3,CACNA1C,CELF4,GRIN2A,NRXN1,AK5,OLFM1,LRRC7,HCN1,PCLO,PTPRG,RIMS2,IL1RAPL2
9.922e-04	-6.92	4.1m	smart domains	SM00294	14	2	9717	33	NRXN3,NRXN1
1.048e-03	-6.86	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	9	16828	48	ZNF804A,GRID2,GABRA6,GRIN2A,ASTN1,NRXN3,RBFOX1,GABRD,GABRA1
1.063e-03	-6.85	Iono_Glu_rcpt_met	interpro domains	IPR001508	18	2	18521	50	GRID2,GRIN2A
1.063e-03	-6.85	Ionotropic_Glu_rcpt	interpro domains	IPR015683	18	2	18521	50	GRID2,GRIN2A
1.063e-03	-6.85	Glu/Gly-bd	interpro domains	IPR019594	18	2	18521	50	GRIN2A,GRID2
1.063e-03	-6.85	Iontro_rcpt_C	interpro domains	IPR001320	18	2	18521	50	GRID2,GRIN2A
1.071e-03	-6.84	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	2	19108	49	UNC13C,GRID2
1.105e-03	-6.81	Lig_chan	pfam domains	PF00060	18	2	17795	49	GRID2,GRIN2A
1.105e-03	-6.81	Lig_chan-Glu_bd	pfam domains	PF10613	18	2	17795	49	GRIN2A,GRID2
1.117e-03	-6.80	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	22	16828	48	R3HDM1,PCLO,HCN1,PTPRG,RIMS2,CACNA1C,UNC13C,GRIN2A,ZFPM2,MYT1L,LRRC7,GRID2,RYR2,KCNT1,ASTN1,ZNF804A,GABBR2,GABRA6,RBFOX1,TRPM3,STXBP5L,CR2
1.147e-03	-6.77	-	gene3d domains	3.30.70.330	245	5	14470	47	RBFOX3,CELF4,RBFOX1,CELF5,CELF6
1.160e-03	-6.76	C2_domain_sf	interpro domains	IPR035892	171	4	18521	50	UNC13C,PCLO,RIMS4,RIMS2
1.179e-03	-6.74	excitatory synapse assembly	biological process	GO:1904861	19	2	18204	49	NRXN1,GRID2
1.179e-03	-6.74	vocalization behavior	biological process	GO:0071625	19	2	18204	49	NRXN3,NRXN1
1.245e-03	-6.69	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	33	16828	48	GABBR2,ZNF804A,CR2,STXBP5L,KSR2,RYR2,GRID2,DLG3,NRXN3,CACNA1C,OLFM1,AK5,R3HDM1,RBFOX3,ST8SIA5,GABRB2,GABRA6,SMPD3,TRPM3,KCNT1,GALNT9,ASTN1,UNC13C,GRIN2A,ZFPM2,CELF4,LRRC7,PTPRG,PCLO,HCN1,CELF5,IL1RAPL2,GABRA1
1.253e-03	-6.68	SALM protein interactions at the synapses	REACTOME pathways	R-HSA-8849932	21	2	10285	26	GRIN2A,DLG3
1.261e-03	-6.68	behavior	biological process	GO:0007610	619	7	18204	49	GRIN2A,NRXN1,ASTN1,HCN1,OPRL1,SLC24A4,NRXN3
1.321e-03	-6.63	PDZ	smart domains	SM00228	143	4	9717	33	PCLO,RIMS2,DLG3,LRRC7
1.366e-03	-6.60	-	gene3d domains	2.30.42.10	149	4	14470	47	LRRC7,DLG3,RIMS2,PCLO
1.398e-03	-6.57	regulation of neurotransmitter secretion	biological process	GO:0046928	82	3	18204	49	CPLX1,RIMS2,RIMS4
1.412e-03	-6.56	regulation of monoatomic cation transmembrane transport	biological process	GO:1904062	309	5	18204	49	CACNA1C,RYR2,GRIN2A,RGS7,KCNIP4
1.418e-03	-6.56	NLGN3 (neuroligin 3)	protein interactions	54413	88	3	19454	49	DLG3,NRXN1,NRXN3
1.443e-03	-6.54	plasma membrane signaling receptor complex	cellular component	GO:0098802	191	4	19108	49	GABBR2,GRIN2A,GRID2,DLG3
1.448e-03	-6.54	spliceosomal complex assembly	biological process	GO:0000245	83	3	18204	49	CELF4,CELF6,CELF5
1.567e-03	-6.46	chondrosarcoma	COSMIC cancer mutations	chondrosarcoma	1181	10	16828	48	HCN1,GRID2,PCLO,R3HDM1,RYR2,GABRA6,CR2,GABRD,STXBP5L,LRRC7
1.584e-03	-6.45	cell communication by electrical coupling	biological process	GO:0010644	22	2	18204	49	RYR2,CACNA1C
1.584e-03	-6.45	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	biological process	GO:0010881	22	2	18204	49	RYR2,CACNA1C
1.592e-03	-6.44	voltage-gated potassium channel complex	cellular component	GO:0008076	90	3	19108	49	KCNMA1,HCN1,KCNIP4
1.603e-03	-6.44	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	41	16828	48	TRPM3,SMPD3,GABRA6,ASTN1,KCNT1,PPP2R5B,NRXN1,LRRC7,CELF4,GRIN2A,UNC13C,ZFPM2,GABRA1,IL1RAPL2,KCNMA1,PCLO,CELF5,HCN1,PTPRG,RBFOX1,KSR2,CR2,STXBP5L,GABBR2,ZNF804A,SLC24A4,OPRL1,CELF6,NRXN3,DLG3,RYR2,GRID2,AK5,OLFM1,MYT1L,GABRD,CACNA1C,RIMS4,ST8SIA5,RGS7,RIMS2
1.617e-03	-6.43	C2 domain	gene3d domains	2.60.40.150	156	4	14470	47	RIMS4,PCLO,RIMS2,UNC13C
1.625e-03	-6.42	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	21	16828	48	UNC13C,GRIN2A,CACNA1C,MYT1L,LRRC7,AK5,PPP2R5B,PTPRG,PCLO,R3HDM1,HCN1,GABRA1,RIMS2,GABRB2,GABRA6,CR2,STXBP5L,KSR2,KCNT1,GRID2,RYR2
1.631e-03	-6.42	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	21	16828	48	LRRC7,MYT1L,PPP2R5B,AK5,UNC13C,GRIN2A,CACNA1C,RIMS2,GABRA1,GABRB2,PTPRG,HCN1,R3HDM1,PCLO,CR2,STXBP5L,KSR2,GABRA6,KCNT1,RYR2,GRID2
1.654e-03	-6.40	PBPe	smart domains	SM00079	18	2	9717	33	GRID2,GRIN2A
1.654e-03	-6.40	Lig_chan-Glu_bd	smart domains	SM00918	18	2	9717	33	GRID2,GRIN2A
1.656e-03	-6.40	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	44	16828	48	CPLX1,RIMS4,AK5,OLFM1,GABRD,MYT1L,R3HDM1,GABRB2,ST8SIA5,GABBR2,KCNIP4,CELF6,RBFOX1,STXBP5L,NRXN3,CELF4,ZFPM2,UNC13C,GRIN2A,LRRC7,CELF5,IL1RAPL2,GABRA1,TRPM3,GALNT9,CACNA1C,RGS7,RBFOX3,ZNF804A,OPRL1,KSR2,CR2,RYR2,GRID2,NRXN1,PPP2R5B,HCN1,PCLO,PTPRG,KCNMA1,GABRA6,SMPD3,KCNT1,ASTN1
1.656e-03	-6.40	CNKSR2 (connector enhancer of kinase suppressor of Ras 2)	protein interactions	22866	24	2	19454	49	LRRC7,DLG3
1.720e-03	-6.37	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	4	19454	49	NRXN3,DLG3,NRXN1,GRIN2A
1.775e-03	-6.33	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	13	16828	48	CR2,CELF6,ASTN1,NRXN3,RYR2,GRID2,MYT1L,ZFPM2,GRIN2A,CACNA1C,KCNMA1,PTPRG,HCN1
1.784e-03	-6.33	extremity	COSMIC cancer mutations	extremity	1876	13	16828	48	GRID2,RYR2,NRXN3,ASTN1,CELF6,CR2,PTPRG,HCN1,KCNMA1,GRIN2A,ZFPM2,CACNA1C,MYT1L
1.828e-03	-6.30	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	21	16828	48	PTPRG,PCLO,R3HDM1,HCN1,GABRA1,RIMS2,GABRB2,GRIN2A,UNC13C,CACNA1C,MYT1L,LRRC7,AK5,PPP2R5B,KCNT1,GRID2,RYR2,GABRA6,STXBP5L,CR2,KSR2
1.850e-03	-6.29	NMDARECEPTOR	prints domains	PR00177	18	2	5227	19	GRIN2A,GRID2
1.856e-03	-6.29	multicellular organismal process	biological process	GO:0032501	6177	27	18204	49	IL1RAPL2,RBFOX1,OPRL1,LRRC7,CR2,SMPD3,GABRA6,INSYN1,RYR2,GABRA1,RBFOX3,SLC24A4,NRXN1,GABRB2,HCN1,CACNA1C,NRXN3,OLFM1,GRID2,GRIN2A,DLG3,CELF4,ASTN1,KCNMA1,ZFPM2,PCLO,MYT1L
1.863e-03	-6.29	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	11	16828	48	SLC24A4,ZFPM2,RBFOX1,GABRD,CR2,MYT1L,RYR2,PCLO,PTPRG,ASTN1,RGS7
1.863e-03	-6.29	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	11	16828	48	ZFPM2,GABRD,MYT1L,PCLO,PTPRG,RGS7,SLC24A4,RBFOX1,CR2,RYR2,ASTN1
1.913e-03	-6.26	human chr4q22.1-q22.2	chromosome location	human chr4q22.1-q22.2	1	1	26134	50	GRID2
1.913e-03	-6.26	human chr12q24.22-q24.23	chromosome location	human chr12q24.22-q24.23	1	1	26134	50	KSR2
1.913e-03	-6.26	human chr4p15.31-p15.2	chromosome location	human chr4p15.31-p15.2	1	1	26134	50	KCNIP4
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr14q24.3-q31.1	chromosome location	human chr14q24.3-q31.1	1	1	26134	50	NRXN3
1.913e-03	-6.26	human chr1q43\|1q23.1	chromosome location	human chr1q43\|1q23.1	1	1	26134	50	RGS7
1.931e-03	-6.25	SERPINA12 (serpin family A member 12)	protein interactions	145264	98	3	19454	49	PTPRG,GALNT9,RBFOX1
1.971e-03	-6.23	Potassium Channels	REACTOME pathways	R-HSA-1296071	100	3	10285	26	HCN1,GABBR2,KCNMA1
2.000e-03	-6.21	anatomical structure development	biological process	GO:0048856	5207	24	18204	49	PCLO,MYT1L,CELF4,GRIN2A,DLG3,ASTN1,ZFPM2,NRXN3,OLFM1,GRID2,NRXN1,CACNA1C,HCN1,GABRB2,RBFOX3,SLC24A4,RYR2,GABRA1,LRRC7,CR2,GABRA6,SMPD3,IL1RAPL2,RBFOX1
2.046e-03	-6.19	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	40	16828	48	CELF4,UNC13C,GRIN2A,ZFPM2,PPP2R5B,NRXN1,LRRC7,PCLO,CELF5,HCN1,PTPRG,GABRA1,IL1RAPL2,GABRA6,TRPM3,KCNT1,ASTN1,CACNA1C,CPLX1,RIMS4,AK5,OLFM1,GABRD,MYT1L,R3HDM1,ST8SIA5,GABRB2,RBFOX3,RIMS2,ZNF804A,GABBR2,OPRL1,CELF6,KSR2,RBFOX1,STXBP5L,CR2,RYR2,GRID2,NRXN3
2.083e-03	-6.17	pancreas-other-cystic_tumour	COSMIC cancer mutations	pancreas-other-cystic_tumour	89	3	16828	48	R3HDM1,KCNT1,AK5
2.083e-03	-6.17	cystic_tumour	COSMIC cancer mutations	cystic_tumour	89	3	16828	48	AK5,R3HDM1,KCNT1
2.085e-03	-6.17	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	48	ST8SIA5,GABRB2,RIMS2,R3HDM1,AK5,OLFM1,MYT1L,GABRD,CPLX1,RIMS4,NRXN3,DLG3,RBFOX1,STXBP5L,KCNIP4,GABBR2,TTC9B,CELF6,IL1RAPL2,GABRA1,CELF5,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,GALNT9,TRPM3,RBFOX3,RGS7,CACNA1C,GRID2,RYR2,KSR2,CR2,ZNF804A,SLC24A4,OPRL1,KCNMA1,PCLO,HCN1,PTPRG,PPP2R5B,NRXN1,ASTN1,KCNT1,SMPD3,GABRA6
2.085e-03	-6.17	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	48	RBFOX1,STXBP5L,GABBR2,KCNIP4,TTC9B,CELF6,NRXN3,DLG3,AK5,MYT1L,GABRD,OLFM1,CPLX1,RIMS4,GABRB2,ST8SIA5,RIMS2,R3HDM1,TRPM3,GALNT9,LRRC7,CELF4,ZFPM2,UNC13C,GRIN2A,GABRA1,IL1RAPL2,CELF5,KSR2,CR2,SLC24A4,ZNF804A,OPRL1,RYR2,GRID2,CACNA1C,RGS7,RBFOX3,SMPD3,GABRA6,ASTN1,KCNT1,NRXN1,PPP2R5B,KCNMA1,HCN1,PCLO,PTPRG
2.095e-03	-6.17	DLGAP1 (DLG associated protein 1)	protein interactions	9229	27	2	19454	49	DLG3,GRIN2A
2.214e-03	-6.11	potassium channel complex	cellular component	GO:0034705	101	3	19108	49	KCNIP4,HCN1,KCNMA1
2.240e-03	-6.10	glutamate receptor activity	molecular function	GO:0008066	26	2	18094	49	GRID2,GRIN2A
2.253e-03	-6.10	GRIK2 (glutamate ionotropic receptor kainate type subunit 2)	protein interactions	2898	28	2	19454	49	GRID2,DLG3
2.312e-03	-6.07	tibia	COSMIC cancer mutations	tibia	836	8	16828	48	LRRC7,KSR2,TRPM3,ZFPM2,ZNF804A,NRXN3,ASTN1,R3HDM1
2.316e-03	-6.07	calmodulin binding	molecular function	GO:0005516	206	4	18094	49	UNC13C,SLC24A4,RYR2,CACNA1C
2.344e-03	-6.06	regulation of monoatomic ion transmembrane transport	biological process	GO:0034765	347	5	18204	49	RGS7,KCNIP4,GRIN2A,RYR2,CACNA1C
2.370e-03	-6.04	thyroid-other-neoplasm	COSMIC cancer mutations	thyroid-other-neoplasm	7637	32	16828	48	RBFOX1,KSR2,CR2,STXBP5L,ZNF804A,GABBR2,CELF6,NRXN3,RYR2,OLFM1,MYT1L,GABRD,CACNA1C,ST8SIA5,RBFOX3,RIMS2,R3HDM1,TRPM3,SMPD3,GABRA6,ASTN1,GALNT9,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,GABRA1,KCNMA1,PCLO,CELF5,PTPRG
2.387e-03	-6.04	cell-cell signaling involved in cardiac conduction	biological process	GO:0086019	27	2	18204	49	CACNA1C,RYR2
2.387e-03	-6.04	regulation of cardiac muscle contraction by calcium ion signaling	biological process	GO:0010882	27	2	18204	49	RYR2,CACNA1C
2.398e-03	-6.03	regulation of neurotransmitter transport	biological process	GO:0051588	99	3	18204	49	RIMS2,RIMS4,CPLX1
2.439e-03	-6.02	voltage-gated potassium channel activity	molecular function	GO:0005249	99	3	18094	49	KCNT1,HCN1,KCNMA1
2.501e-03	-5.99	Periplasmic binding protein-like II	gene3d domains	3.40.190.10	23	2	14470	47	GRIN2A,GRID2
2.519e-03	-5.98	Akap7 (A-kinase anchoring protein 7)	protein interactions	361458	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Zmpste24 (zinc metallopeptidase STE24)	protein interactions	313564	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Itln1 (intelectin 1)	protein interactions	498284	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dync1i2 (dynein cytoplasmic 1 intermediate chain 2)	protein interactions	116659	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)	protein interactions	301458	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ndufb8 (NADH:ubiquinone oxidoreductase subunit B8)	protein interactions	293991	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Iapp (islet amyloid polypeptide)	protein interactions	24476	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Snrpa (small nuclear ribonucleoprotein polypeptide A)	protein interactions	292729	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rab5c (RAB5C, member RAS oncogene family)	protein interactions	287709	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nomo1 (Nodal modulator 1)	protein interactions	361578	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tardbp (TAR DNA binding protein)	protein interactions	298648	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Stoml2 (stomatin like 2)	protein interactions	298203	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC100361008 (Cytochrome c oxidase subunit 5A, mitochondrial-like)	protein interactions	100361008	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmgn5b (high mobility group nucleosome binding domain 5B)	protein interactions	120097335	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ina (internexin neuronal intermediate filament protein, alpha)	protein interactions	24503	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gpd2 (glycerol-3-phosphate dehydrogenase 2)	protein interactions	25062	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgk2 (phosphoglycerate kinase 2)	protein interactions	316265	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC102554637 (anionic trypsin-2-like)	protein interactions	102554637	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Phb1l1 (prohibitin 1 like 1)	protein interactions	302688	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copb1 (COPI coat complex subunit beta 1)	protein interactions	114023	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Bst2 (bone marrow stromal cell antigen 2)	protein interactions	378947	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Syvn1 (synoviolin 1)	protein interactions	361712	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Usp15 (ubiquitin specific peptidase 15)	protein interactions	171329	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tpd52l2 (TPD52 like 2)	protein interactions	296480	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Purb (purine rich element binding protein B)	protein interactions	498407	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cct3 (chaperonin containing TCP1 subunit 3)	protein interactions	295230	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tor1aip2 (torsin 1A interacting protein 2)	protein interactions	304881	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tmed2 (transmembrane p24 trafficking protein 2)	protein interactions	65165	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dnajb11 (DnaJ heat shock protein family (Hsp40) member B11)	protein interactions	360734	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Camk2b (calcium/calmodulin-dependent protein kinase II beta)	protein interactions	24245	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Fstl4 (follistatin-like 4)	protein interactions	303130	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cyp2c55 (cytochrome P450, family 2, subfamily c, polypeptide 55)	protein interactions	100361492	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgrmc1 (progesterone receptor membrane component 1)	protein interactions	291948	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Zc3h13 (zinc finger CCCH type containing 13)	protein interactions	305955	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Myef2 (myelin expression factor 2)	protein interactions	679712	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Timm44 (translocase of inner mitochondrial membrane 44)	protein interactions	29635	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Krt83 (keratin 83)	protein interactions	407759	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Actg2 (actin gamma 2, smooth muscle)	protein interactions	25365	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	246333	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Actr1a (actin related protein 1A)	protein interactions	294010	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kiaa0232 (KIAA0232 homolog)	protein interactions	680039	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sphkap (SPHK1 interactor, AKAP domain containing)	protein interactions	316561	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gorasp2 (golgi reassembly stacking protein 2)	protein interactions	113961	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copg1 (COPI coat complex subunit gamma 1)	protein interactions	297428	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sel1l (SEL1L adaptor subunit of SYVN1 ubiquitin ligase)	protein interactions	314352	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cox5b (cytochrome c oxidase subunit 5B)	protein interactions	94194	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Eif3b (eukaryotic translation initiation factor 3, subunit B)	protein interactions	288516	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cd81 (Cd81 molecule)	protein interactions	25621	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gaa (alpha glucosidase)	protein interactions	367562	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kcnd2 (potassium voltage-gated channel subfamily D member 2)	protein interactions	65180	1	1	19454	49	KCNIP4
2.519e-03	-5.98	Rnf13 (ring finger protein 13)	protein interactions	681578	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ptma (prothymosin alpha)	protein interactions	29222	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copb2 (COPI coat complex subunit beta 2)	protein interactions	60384	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgam1 (phosphoglycerate mutase 1)	protein interactions	24642	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kpna2l1 (karyopherin subunit alpha 2 like 1)	protein interactions	100359600	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cep135 (centrosomal protein 135)	protein interactions	305288	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tceal3 (transcription elongation factor A like 3)	protein interactions	501628	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cep162 (centrosomal protein 162)	protein interactions	300880	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Stxbp5l (syntaxin binding protein 5L)	protein interactions	288080	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ppard (peroxisome proliferator-activated receptor delta)	protein interactions	25682	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hnrnpul2 (heterogeneous nuclear ribonucleoprotein U-like 2)	protein interactions	309197	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rps26-ps11 (ribosomal protein S26, pseudogene 11)	protein interactions	100360508	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmgn3 (high mobility group nucleosomal binding domain 3)	protein interactions	113990	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nnt (nicotinamide nucleotide transhydrogenase)	protein interactions	310378	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hnrnph3 (heterogeneous nuclear ribonucleoprotein H3)	protein interactions	361838	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rpl31-ps10 (ribosomal protein L31, pseudogene 10)	protein interactions	502887	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp6v0d1 (ATPase H+ transporting V0 subunit D1)	protein interactions	291969	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pdia6 (protein disulfide isomerase family A, member 6)	protein interactions	286906	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Srprb (SRP receptor subunit beta)	protein interactions	300965	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Krt8 (keratin 8)	protein interactions	25626	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Fam114a1 (family with sequence similarity 114, member A1)	protein interactions	498366	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tgoln2 (trans-golgi network protein 2)	protein interactions	192152	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copa (COPI coat complex subunit alpha)	protein interactions	304978	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp5f1d (ATP synthase F1 subunit delta)	protein interactions	245965	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Vil1 (villin 1)	protein interactions	316521	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tmem263 (transmembrane protein 263)	protein interactions	362857	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ttc22 (tetratricopeptide repeat domain 22)	protein interactions	298300	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC286987 (hemiferrin, transferrin-like protein)	protein interactions	286987	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ranbp1 (RAN binding protein 1)	protein interactions	360739	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Acad10 (acyl-CoA dehydrogenase family, member 10)	protein interactions	304500	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atxn2 (ataxin 2)	protein interactions	288663	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Chmp4b (charged multivesicular body protein 4B)	protein interactions	100359642	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gcn1 (GCN1 activator of EIF2AK4)	protein interactions	690632	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cope (COPI coat complex subunit epsilon)	protein interactions	290659	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Vgf (VGF nerve growth factor inducible)	protein interactions	29461	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dnah17 (dynein, axonemal, heavy chain 17)	protein interactions	287845	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tuba1c (tubulin, alpha 1C)	protein interactions	300218	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Snrnp27 (small nuclear ribonucleoprotein U4/U6.U5 subunit 27)	protein interactions	362392	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp6v0a1 (ATPase H+ transporting V0 subunit a1)	protein interactions	29757	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hnrnpr (heterogeneous nuclear ribonucleoprotein R)	protein interactions	319110	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Stip1 (stress-induced phosphoprotein 1)	protein interactions	192277	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ndufv3-ps1 (NADH:ubiquinone oxidoreductase subunit V3, pseudogene 1)	protein interactions	685005	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rps27-ps8 (ribosomal protein S27, pseudogene 8)	protein interactions	100359517	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Psap (prosaposin)	protein interactions	25524	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nbas (NBAS subunit of NRZ tethering complex)	protein interactions	690073	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hdgfl3 (HDGF like 3)	protein interactions	252941	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC100360522 (ribosomal protein P1-like)	protein interactions	100360522	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Mlec (malectin)	protein interactions	304543	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hspa4 (heat shock protein family A (Hsp70) member 4)	protein interactions	266759	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC100365839 (40S ribosomal protein S3a-like)	protein interactions	100365839	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dynll2 (dynein light chain LC8-type 2)	protein interactions	140734	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dynll1 (dynein light chain LC8-type 1)	protein interactions	58945	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nolc1 (nucleolar and coiled-body phosphoprotein 1)	protein interactions	64896	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Grpel1 (GrpE-like 1, mitochondrial)	protein interactions	79563	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gfpt1 (glutamine fructose-6-phosphate transaminase 1)	protein interactions	297417	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC297756 (ribosomal protein S8-like)	protein interactions	297756	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp5mc2 (ATP synthase membrane subunit c locus 2)	protein interactions	171082	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Qpct (glutaminyl-peptide cyclotransferase)	protein interactions	313837	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ciao2b (cytosolic iron-sulfur assembly component 2B)	protein interactions	680987	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Fam114a2 (family with sequence similarity 114, member A2)	protein interactions	303155	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2)	protein interactions	24212	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Scg5 (secretogranin V)	protein interactions	25719	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kif5b (kinesin family member 5B)	protein interactions	117550	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Trim28 (tripartite motif-containing 28)	protein interactions	116698	1	1	19454	49	STXBP5L
2.519e-03	-5.98	U2af2 (U2 small nuclear RNA auxiliary factor 2)	protein interactions	308335	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cnbp (CCHC-type zinc finger, nucleic acid binding protein)	protein interactions	64530	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hba-a2 (hemoglobin alpha, adult chain 2)	protein interactions	360504	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Phb2 (prohibitin 2)	protein interactions	114766	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Anxa5 (annexin A5)	protein interactions	25673	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Abca4 (ATP binding cassette subfamily A member 4)	protein interactions	310836	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sec11a (SEC11 homolog A, signal peptidase complex subunit)	protein interactions	65166	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cul3 (cullin 3)	protein interactions	301555	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ranbp2 (RAN binding protein 2)	protein interactions	294429	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rps12l1 (ribosomal protein S12 like 1)	protein interactions	100360573	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cep192 (centrosomal protein 192)	protein interactions	307347	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Marcksl1 (MARCKS-like 1)	protein interactions	81520	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sec16a (SEC16 homolog A, endoplasmic reticulum export factor)	protein interactions	100360302	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Npm1-ps9 (nucleophosmin 1, pseudogene 9)	protein interactions	300303	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Arsb (arylsulfatase B)	protein interactions	25227	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sel1l2 (SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase)	protein interactions	311470	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cse1l (chromosome segregation 1 like)	protein interactions	362273	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ccar2 (cell cycle and apoptosis regulator 2)	protein interactions	306007	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sh3glb1 (SH3 domain -containing GRB2-like endophilin B1)	protein interactions	292156	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tuba4a (tubulin, alpha 4A)	protein interactions	316531	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cdc37 (cell division cycle 37, HSP90 cochaperone)	protein interactions	114562	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Os9 (OS9, endoplasmic reticulum lectin)	protein interactions	362891	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Amz2 (archaelysin family metallopeptidase 2)	protein interactions	360650	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Srsf4 (serine and arginine rich splicing factor 4)	protein interactions	362612	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgam5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)	protein interactions	288731	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Slc7a5 (solute carrier family 7 member 5)	protein interactions	50719	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tnpo1 (transportin 1)	protein interactions	309126	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Scgn (secretagogin, EF-hand calcium binding protein)	protein interactions	306942	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Vwa5b2 (von Willebrand factor A domain containing 5B2)	protein interactions	303812	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Psma3l (proteasome subunit alpha type 3-like)	protein interactions	408248	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmgn2 (high mobility group nucleosomal binding domain 2)	protein interactions	114637	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rpl17-ps1 (ribosomal protein L17, pseudogene 1)	protein interactions	499485	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Glg1 (golgi glycoprotein 1)	protein interactions	29476	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ermp1 (endoplasmic reticulum metallopeptidase 1)	protein interactions	373544	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Jpt1 (Jupiter microtubule associated homolog 1)	protein interactions	287828	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gps1 (G protein pathway suppressor 1)	protein interactions	117039	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sod1 (superoxide dismutase 1)	protein interactions	24786	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ganab (glucosidase II alpha subunit)	protein interactions	293721	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dnaaf3 (dynein, axonemal, assembly factor 3)	protein interactions	100359753	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kifc2 (kinesin family member C2)	protein interactions	300053	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sncb (synuclein, beta)	protein interactions	113893	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Spcs2 (signal peptidase complex subunit 2)	protein interactions	293142	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Taf15 (TATA-box binding protein associated factor 15)	protein interactions	287571	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Trip11 (thyroid hormone receptor interactor 11)	protein interactions	314393	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ins2 (insulin 2)	protein interactions	24506	1	1	19454	49	STXBP5L
2.519e-03	-5.98	C1qbp (complement C1q binding protein)	protein interactions	29681	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmga1 (high mobility group AT-hook 1)	protein interactions	117062	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	49	NRXN1
2.519e-03	-5.98	Ptmal5 (prothymosin alpha like 5)	protein interactions	100359583	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tmem109 (transmembrane protein 109)	protein interactions	361732	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Babam1 (BRISC and BRCA1 A complex member 1)	protein interactions	290631	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pdhb (pyruvate dehydrogenase E1 subunit beta)	protein interactions	289950	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cplx2 (complexin 2)	protein interactions	116657	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nudc (nuclear distribution C, dynein complex regulator)	protein interactions	29648	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ptms (parathymosin)	protein interactions	83801	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Mroh6 (maestro heat-like repeat family member 6)	protein interactions	100359562	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Lmnb2 (lamin B2)	protein interactions	299625	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Mcm3 (minichromosome maintenance complex component 3)	protein interactions	316273	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hm13 (histocompatibility minor 13)	protein interactions	311545	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Scfd1 (sec1 family domain containing 1)	protein interactions	54350	1	1	19454	49	STXBP5L
2.563e-03	-5.97	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	8	16828	48	GRID2,GABRB2,ASTN1,RIMS2,GRIN2A,RBFOX1,GABRD,STXBP5L
2.564e-03	-5.97	cerebellar Golgi cell to granule cell synapse	cellular component	GO:0099192	1	1	19108	49	GABRA6
2.566e-03	-5.97	startle response	biological process	GO:0001964	28	2	18204	49	GRID2,GRIN2A
2.566e-03	-5.97	calcium ion import across plasma membrane	biological process	GO:0098703	28	2	18204	49	SLC24A4,CACNA1C
2.580e-03	-5.96	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	10	16828	48	ZNF804A,KCNIP4,CACNA1C,LRRC7,OLFM1,PTPRG,HCN1,RYR2,PCLO,RIMS2
2.580e-03	-5.96	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	10	16828	48	PTPRG,PCLO,RYR2,HCN1,RIMS2,CACNA1C,KCNIP4,ZNF804A,LRRC7,OLFM1
2.614e-03	-5.95	PRR20A (proline rich 20A)	protein interactions	122183	109	3	19454	49	TRPM3,RBFOX1,CELF4
2.692e-03	-5.92	polysaccharide transport	biological process	GO:0015774	1	1	18204	49	SMPD3
2.692e-03	-5.92	regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane	biological process	GO:0099145	1	1	18204	49	CPLX1
2.692e-03	-5.92	cone photoresponse recovery	biological process	GO:0036368	1	1	18204	49	SLC24A4
2.692e-03	-5.92	regulation of retina development in camera-type eye	biological process	GO:1902866	1	1	18204	49	CELF4
2.692e-03	-5.92	dADP biosynthetic process	biological process	GO:0006173	1	1	18204	49	AK5
2.700e-03	-5.91	GBR2_CC	interpro domains	IPR041689	1	1	18521	50	GABBR2
2.700e-03	-5.91	X_opioid_rcpt	interpro domains	IPR001420	1	1	18521	50	OPRL1
2.700e-03	-5.91	Sphingomyelinase/PLipase_C	interpro domains	IPR017766	1	1	18521	50	SMPD3
2.700e-03	-5.91	GPCR_3_GABA_rcpt_B2	interpro domains	IPR002457	1	1	18521	50	GABBR2
2.700e-03	-5.91	GABBAa6_rcpt	interpro domains	IPR005436	1	1	18521	50	GABRA6
2.700e-03	-5.91	DLG3_SH3	interpro domains	IPR035763	1	1	18521	50	DLG3
2.700e-03	-5.91	VDCC_L_a1csu	interpro domains	IPR005451	1	1	18521	50	CACNA1C
2.700e-03	-5.91	MARCHF4_RING_CH-C4HC3	interpro domains	IPR047905	1	1	18521	50	MARCHF4
2.700e-03	-5.91	GABAAd_rcpt	interpro domains	IPR008098	1	1	18521	50	GABRD
2.700e-03	-5.91	PCLO_FYVE1	interpro domains	IPR042720	1	1	18521	50	PCLO
2.700e-03	-5.91	GABRA1_ECD	interpro domains	IPR047079	1	1	18521	50	GABRA1
2.700e-03	-5.91	GABBAa1_rcpt	interpro domains	IPR005431	1	1	18521	50	GABRA1
2.700e-03	-5.91	KSR_SAM-like_dom	interpro domains	IPR025561	1	1	18521	50	KSR2
2.708e-03	-5.91	neutral sphingomyelin phosphodiesterase activity	molecular function	GO:0061751	1	1	18094	49	SMPD3
2.708e-03	-5.91	nociceptin receptor activity	molecular function	GO:0001626	1	1	18094	49	OPRL1
2.708e-03	-5.91	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0140232	1	1	18094	49	HCN1
2.740e-03	-5.90	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	3	16828	48	ZNF804A,NRXN3,KSR2
2.749e-03	-5.90	cortical cytoskeleton	cellular component	GO:0030863	109	3	19108	49	RIMS4,PCLO,RIMS2
2.751e-03	-5.90	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	47	16828	48	LRRC7,UNC13C,GRIN2A,ZFPM2,CELF4,GABRA1,IL1RAPL2,CELF5,TRPM3,GALNT9,MYT1L,OLFM1,GABRD,AK5,RIMS4,CPLX1,RIMS2,ST8SIA5,GABRB2,R3HDM1,STXBP5L,RBFOX1,CELF6,GABBR2,KCNIP4,DLG3,NRXN3,PPP2R5B,NRXN1,KCNMA1,PTPRG,PCLO,HCN1,SMPD3,GABRA6,ASTN1,KCNT1,CACNA1C,RGS7,RBFOX3,CR2,KSR2,OPRL1,ZNF804A,SLC24A4,GRID2,RYR2
2.751e-03	-5.90	calcium ion import into cytosol	biological process	GO:1902656	29	2	18204	49	SLC24A4,CACNA1C
2.751e-03	-5.90	regulation of cardiac muscle cell action potential	biological process	GO:0098901	29	2	18204	49	RYR2,CACNA1C
2.754e-03	-5.89	GBR2_CC	pfam domains	PF18455	1	1	17795	49	GABBR2
2.754e-03	-5.89	SAM_KSR1	pfam domains	PF13543	1	1	17795	49	KSR2
2.758e-03	-5.89	ABCB9 (ATP binding cassette subfamily B member 9)	protein interactions	23457	31	2	19454	49	MARCHF4,GRIN2A
2.784e-03	-5.88	ligand-gated calcium channel activity	molecular function	GO:0099604	29	2	18094	49	GRIN2A,RYR2
2.801e-03	-5.88	pancreatic_intraepithelial_neoplasia_(PanIN)	COSMIC cancer mutations	pancreatic_intraepithelial_neoplasia_(PanIN)	673	7	16828	48	RYR2,ASTN1,KCNMA1,GALNT9,RBFOX1,LRRC7,CR2
2.801e-03	-5.88	pancreas-pancreatic_intraepithelial_neoplasia_(PanIN)	COSMIC cancer mutations	pancreas-pancreatic_intraepithelial_neoplasia_(PanIN)	673	7	16828	48	RYR2,LRRC7,CR2,KCNMA1,GALNT9,RBFOX1,ASTN1
2.916e-03	-5.84	cell junction organization	biological process	GO:0034330	532	6	18204	49	GRID2,GABRA6,GABRB2,NRXN1,GABRA1,PCLO
2.978e-03	-5.82	monoatomic ion-gated channel activity	molecular function	GO:0022839	30	2	18094	49	KCNMA1,KCNT1
3.040e-03	-5.80	SNARE binding	molecular function	GO:0000149	107	3	18094	49	CPLX1,UNC13C,STXBP5L
3.041e-03	-5.80	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	7	16828	48	KCNIP4,NRXN1,STXBP5L,RYR2,PTPRG,KCNT1,GALNT9
3.041e-03	-5.80	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	7	16828	48	STXBP5L,NRXN1,KCNIP4,GALNT9,PTPRG,KCNT1,RYR2
3.127e-03	-5.77	macromolecule localization	biological process	GO:0033036	2376	14	18204	49	RYR2,DLG3,GRIN2A,KCNIP4,PCLO,RIMS2,NRXN1,CPLX1,HCN1,STXBP5L,RBFOX1,LRRC7,SMPD3,GRID2
3.140e-03	-5.76	protein localization to postsynaptic membrane	biological process	GO:1903539	31	2	18204	49	LRRC7,GRIN2A
3.140e-03	-5.76	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0010880	31	2	18204	49	CACNA1C,RYR2
3.175e-03	-5.75	upper_leg	COSMIC cancer mutations	upper_leg	880	8	16828	48	GRID2,RIMS2,ASTN1,GABRB2,GRIN2A,GABRD,STXBP5L,RBFOX1
3.177e-03	-5.75	intracellularly ligand-gated monoatomic ion channel activity	molecular function	GO:0005217	31	2	18094	49	HCN1,RYR2
3.220e-03	-5.74	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	39	16828	48	NRXN3,GRID2,RYR2,KSR2,STXBP5L,CR2,GABBR2,KCNIP4,SLC24A4,ZNF804A,OPRL1,ST8SIA5,RGS7,RIMS2,R3HDM1,AK5,MYT1L,GABRD,CACNA1C,CPLX1,RIMS4,ASTN1,GALNT9,KCNT1,TRPM3,GABRA6,IL1RAPL2,GABRA1,KCNMA1,PCLO,CELF5,HCN1,PTPRG,NRXN1,LRRC7,CELF4,GRIN2A,UNC13C,ZFPM2
3.220e-03	-5.74	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	39	16828	48	GABRA6,TRPM3,KCNT1,GALNT9,ASTN1,UNC13C,GRIN2A,ZFPM2,CELF4,LRRC7,NRXN1,PTPRG,PCLO,CELF5,HCN1,IL1RAPL2,GABRA1,KCNMA1,OPRL1,KCNIP4,GABBR2,SLC24A4,ZNF804A,STXBP5L,CR2,KSR2,RYR2,GRID2,NRXN3,RIMS4,CACNA1C,CPLX1,MYT1L,GABRD,AK5,R3HDM1,RGS7,RIMS2,ST8SIA5
3.270e-03	-5.72	developmental process	biological process	GO:0032502	5716	25	18204	49	RBFOX3,SLC24A4,GABRA1,RYR2,LRRC7,CR2,GABRA6,SMPD3,RIMS2,IL1RAPL2,RBFOX1,PCLO,MYT1L,CELF4,GRIN2A,DLG3,ASTN1,ZFPM2,NRXN3,OLFM1,GRID2,NRXN1,CACNA1C,GABRB2,HCN1
3.312e-03	-5.71	ABCC10 (ATP binding cassette subfamily C member 10)	protein interactions	89845	34	2	19454	49	MARCHF4,OPRL1
3.315e-03	-5.71	cell-cell adhesion	biological process	GO:0098609	546	6	18204	49	NRXN3,ASTN1,GRID2,DLG3,LRRC7,NRXN1
3.326e-03	-5.71	adenosine ribonucleotides de novo biosynthesis	BIOCYC pathways	META_PWY-7219	1	1	902	3	AK5
3.344e-03	-5.70	protein localization to postsynapse	biological process	GO:0062237	32	2	18204	49	LRRC7,GRIN2A
3.406e-03	-5.68	localization within membrane	biological process	GO:0051668	549	6	18204	49	STXBP5L,KCNIP4,LRRC7,GRIN2A,DLG3,NRXN1
3.430e-03	-5.68	ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15)	protein interactions	158866	120	3	19454	49	RIMS2,NRXN1,STXBP5L
3.475e-03	-5.66	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	36	16828	48	RYR2,GRID2,NRXN3,DLG3,ZNF804A,GABBR2,OPRL1,KSR2,STXBP5L,CR2,R3HDM1,GABRB2,ST8SIA5,RIMS2,RGS7,RBFOX3,CACNA1C,RIMS4,AK5,OLFM1,KCNT1,ASTN1,GABRA6,TRPM3,SMPD3,HCN1,PCLO,PTPRG,KCNMA1,IL1RAPL2,CELF4,ZFPM2,GRIN2A,UNC13C,PPP2R5B,LRRC7
3.543e-03	-5.64	RNA splicing	biological process	GO:0008380	382	5	18204	49	CELF6,RBFOX1,CELF5,RBFOX3,CELF4
3.635e-03	-5.62	LVDCCALPHA1C	prints domains	PR01635	1	1	5227	19	CACNA1C
3.635e-03	-5.62	GABAARALPHA6	prints domains	PR01619	1	1	5227	19	GABRA6
3.635e-03	-5.62	GABAARALPHA1	prints domains	PR01614	1	1	5227	19	GABRA1
3.635e-03	-5.62	GABAB2RECPTR	prints domains	PR01178	1	1	5227	19	GABBR2
3.635e-03	-5.62	GABAARDELTA	prints domains	PR01722	1	1	5227	19	GABRD
3.635e-03	-5.62	XOPIOIDR	prints domains	PR00547	1	1	5227	19	OPRL1
3.714e-03	-5.60	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	48	GRIN2A,GABRA6,GRID2,ZNF804A,GABRA1,GABRD,RBFOX1,NRXN3,ASTN1
3.742e-03	-5.59	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	45	16828	48	CELF5,IL1RAPL2,GABRA1,ZFPM2,GRIN2A,UNC13C,CELF4,LRRC7,GALNT9,TRPM3,R3HDM1,RIMS2,GABRB2,ST8SIA5,RIMS4,MYT1L,GABRD,OLFM1,AK5,DLG3,NRXN3,KCNIP4,GABBR2,STXBP5L,RBFOX1,PTPRG,HCN1,PCLO,KCNMA1,NRXN1,PPP2R5B,KCNT1,ASTN1,GABRA6,SMPD3,RGS7,RBFOX3,CACNA1C,RYR2,GRID2,OPRL1,ZNF804A,SLC24A4,CR2,KSR2
3.844e-03	-5.56	regulation of synapse assembly	biological process	GO:0051963	117	3	18204	49	GRID2,IL1RAPL2,NRXN1
3.898e-03	-5.55	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-polycythaemia_vera	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-polycythaemia_vera	369	5	16828	48	GRIN2A,RYR2,KCNMA1,KSR2,ST8SIA5
3.898e-03	-5.55	polycythaemia_vera	COSMIC cancer mutations	polycythaemia_vera	369	5	16828	48	KSR2,ST8SIA5,KCNMA1,RYR2,GRIN2A
3.976e-03	-5.53	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-cortisol_and_virilizing_syndrome-producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-cortisol_and_virilizing_syndrome-producing	33	2	16828	48	GRIN2A,CACNA1C
3.990e-03	-5.52	regulation of presynapse organization	biological process	GO:0099174	35	2	18204	49	IL1RAPL2,GRID2
3.990e-03	-5.52	regulation of presynapse assembly	biological process	GO:1905606	35	2	18204	49	IL1RAPL2,GRID2
3.990e-03	-5.52	regulation of cardiac muscle cell contraction	biological process	GO:0086004	35	2	18204	49	CACNA1C,RYR2
4.012e-03	-5.52	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	9	16828	48	LRRC7,KSR2,CACNA1C,ZNF804A,GABRA1,DLG3,ASTN1,PTPRG,RYR2
4.128e-03	-5.49	regulation of system process	biological process	GO:0044057	571	6	18204	49	CACNA1C,RIMS2,NRXN1,RYR2,CELF4,GRIN2A
4.218e-03	-5.47	response to amphetamine	biological process	GO:0001975	36	2	18204	49	RGS7,GRIN2A
4.218e-03	-5.47	positive regulation of synaptic transmission, glutamatergic	biological process	GO:0051968	36	2	18204	49	GRIN2A,NRXN1
4.269e-03	-5.46	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	377	5	16828	48	ZFPM2,LRRC7,TRPM3,NRXN1,ASTN1
4.281e-03	-5.45	regulation of synapse organization	biological process	GO:0050807	246	4	18204	49	NRXN1,IL1RAPL2,GRID2,ZNF804A
4.339e-03	-5.44	ABCD4 (ATP binding cassette subfamily D member 4)	protein interactions	5826	39	2	19454	49	MARCHF4,GRIN2A
4.339e-03	-5.44	E (envelope protein)	protein interactions	14254599	39	2	19454	49	LRRC7,RIMS2
4.404e-03	-5.43	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	9	16828	48	CACNA1C,ZNF804A,LRRC7,KSR2,PTPRG,RYR2,GABRA1,DLG3,ASTN1
4.408e-03	-5.42	Laminin_G_2	pfam domains	PF02210	36	2	17795	49	NRXN1,NRXN3
4.492e-03	-5.41	regulation of mRNA metabolic process	biological process	GO:1903311	404	5	18204	49	RBFOX1,CELF6,CELF5,CELF4,RBFOX3
4.519e-03	-5.40	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	11	16828	48	STXBP5L,CR2,SMPD3,OPRL1,GABRA6,NRXN3,KCNT1,OLFM1,LRRC7,NRXN1,RIMS2
4.523e-03	-5.40	action potential	biological process	GO:0001508	124	3	18204	49	RYR2,CACNA1C,HCN1
4.660e-03	-5.37	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	6	16828	48	ASTN1,STXBP5L,CR2,R3HDM1,GRIN2A,GABRA6
4.662e-03	-5.37	regulation of synapse structure or activity	biological process	GO:0050803	252	4	18204	49	IL1RAPL2,NRXN1,ZNF804A,GRID2
4.722e-03	-5.36	dendrite membrane	cellular component	GO:0032590	40	2	19108	49	GABRA1,GABRA6
4.751e-03	-5.35	protein localization	biological process	GO:0008104	1954	12	18204	49	PCLO,RYR2,DLG3,GRIN2A,KCNIP4,LRRC7,GRID2,NRXN1,RIMS2,CPLX1,HCN1,STXBP5L
4.761e-03	-5.35	NCAM signaling for neurite out-growth	REACTOME pathways	R-HSA-375165	276	4	10285	26	KSR2,GRIN2A,PPP2R5B,CACNA1C
4.767e-03	-5.35	fibula	COSMIC cancer mutations	fibula	387	5	16828	48	LRRC7,TRPM3,ASTN1,NRXN1,ZFPM2
4.783e-03	-5.34	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	6	16828	48	ASTN1,PCLO,RYR2,ZFPM2,GABRA6,GRIN2A
4.867e-03	-5.33	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	6	16828	48	ASTN1,RYR2,PCLO,GRIN2A,ZFPM2,GABRA6
4.910e-03	-5.32	cellular macromolecule localization	biological process	GO:0070727	1962	12	18204	49	PCLO,RYR2,DLG3,GRIN2A,KCNIP4,GRID2,LRRC7,HCN1,CPLX1,STXBP5L,NRXN1,RIMS2
5.011e-03	-5.30	LAM_G_DOMAIN	prosite domains	PS50025	35	2	12186	37	NRXN1,NRXN3
5.018e-03	-5.29	RYR2 (ryanodine receptor 2)	protein interactions	6262	42	2	19454	49	RYR2,CACNA1C
5.031e-03	-5.29	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	protein interactions	84026	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Cox4i1 (cytochrome c oxidase subunit 4i1)	protein interactions	29445	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ubap2l (ubiquitin associated protein 2-like)	protein interactions	361984	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Atp5pf (ATP synthase peripheral stalk subunit F6)	protein interactions	94271	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rpsa (ribosomal protein SA)	protein interactions	29236	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tnpo2 (transportin 2)	protein interactions	304670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Plec (plectin)	protein interactions	64204	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Prdx2 (peroxiredoxin 2)	protein interactions	29338	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tmod3 (tropomodulin 3)	protein interactions	300838	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ndufv2 (NADH:ubiquinone oxidoreductase core subunit V2)	protein interactions	81728	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ndufv3 (NADH:ubiquinone oxidoreductase subunit V3)	protein interactions	64539	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Chchd3 (coiled-coil-helix-coiled-coil-helix domain containing 3)	protein interactions	296966	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Atp5pd (ATP synthase peripheral stalk subunit d)	protein interactions	641434	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Psma3 (proteasome 20S subunit alpha 3)	protein interactions	29670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Gsn (gelsolin)	protein interactions	296654	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tpm4 (tropomyosin 4)	protein interactions	24852	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Mycbp (Myc binding protein)	protein interactions	100361133	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Psmd3 (proteasome 26S subunit, non-ATPase 3)	protein interactions	287670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Lrrfip2 (LRR binding FLII interacting protein 2)	protein interactions	301035	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ckap4 (cytoskeleton-associated protein 4)	protein interactions	362859	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	65028	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Sec31a (SEC31 homolog A, COPII coat complex component)	protein interactions	93646	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Lmo7 (LIM domain 7)	protein interactions	361084	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Hadha (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha)	protein interactions	170670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tcp1 (t-complex 1)	protein interactions	24818	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rplp1 (ribosomal protein lateral stalk subunit P1)	protein interactions	140661	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Dbn1 (drebrin 1)	protein interactions	81653	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rab5b (RAB5B, member RAS oncogene family)	protein interactions	288779	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rcn1 (reticulocalbin 1)	protein interactions	362182	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Gnb1 (G protein subunit beta 1)	protein interactions	24400	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Mfap1a (microfibrillar-associated protein 1A)	protein interactions	499878	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Nucb1 (nucleobindin 1)	protein interactions	84595	2	1	19454	49	STXBP5L
5.031e-03	-5.29	AOAH (acyloxyacyl hydrolase)	protein interactions	313	2	1	19454	49	DLG3
5.031e-03	-5.29	Ncl (nucleolin)	protein interactions	25135	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Thy1 (Thy-1 cell surface antigen)	protein interactions	24832	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Myl12b (myosin light chain 12B)	protein interactions	50685	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Eef1b2 (eukaryotic translation elongation factor 1 beta 2)	protein interactions	363241	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rab3a (RAB3A, member RAS oncogene family)	protein interactions	25531	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Myo18a (myosin XVIIIa)	protein interactions	360570	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Sytl4 (synaptotagmin-like 4)	protein interactions	140594	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tufm (Tu translation elongation factor, mitochondrial)	protein interactions	293481	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Eif4b (eukaryotic translation initiation factor 4B)	protein interactions	300253	2	1	19454	49	STXBP5L
5.085e-03	-5.28	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-essential_thrombocythaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-essential_thrombocythaemia	393	5	16828	48	CR2,STXBP5L,ASTN1,CELF4,CELF5
5.085e-03	-5.28	essential_thrombocythaemia	COSMIC cancer mutations	essential_thrombocythaemia	393	5	16828	48	ASTN1,CR2,STXBP5L,CELF5,CELF4
5.122e-03	-5.27	synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex	cellular component	GO:0070554	2	1	19108	49	CPLX1
5.122e-03	-5.27	G protein-coupled GABA receptor complex	cellular component	GO:1902712	2	1	19108	49	GABBR2
5.173e-03	-5.26	PTPRA (protein tyrosine phosphatase receptor type A)	protein interactions	5786	139	3	19454	49	MARCHF4,KCNMA1,PTPRG
5.173e-03	-5.26	SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3)	protein interactions	6457	139	3	19454	49	RBFOX1,RBFOX3,GABBR2
5.187e-03	-5.26	calcium ion import	biological process	GO:0070509	40	2	18204	49	CACNA1C,SLC24A4
5.187e-03	-5.26	bone-humerus-chondrosarcoma	COSMIC cancer mutations	bone-humerus-chondrosarcoma	123	3	16828	48	RYR2,PCLO,R3HDM1
5.203e-03	-5.26	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	30	16828	48	ZNF804A,GABBR2,STXBP5L,CR2,KSR2,GRID2,RYR2,NRXN3,CACNA1C,OLFM1,AK5,R3HDM1,RBFOX3,ST8SIA5,GABRB2,GABRA6,KCNT1,GALNT9,ASTN1,UNC13C,GRIN2A,ZFPM2,CELF4,LRRC7,PTPRG,PCLO,HCN1,CELF5,GABRA1,IL1RAPL2
5.215e-03	-5.26	distal axon	cellular component	GO:0150034	273	4	19108	49	CPLX1,UNC13C,OLFM1,ZNF804A
5.309e-03	-5.24	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	26	RYR2,CACNA1C,KCNIP4
5.376e-03	-5.23	cellular response to high light intensity	biological process	GO:0071486	2	1	18204	49	SLC24A4
5.376e-03	-5.23	neurotransmitter receptor transport postsynaptic membrane to endosome	biological process	GO:0098968	2	1	18204	49	LRRC7
5.376e-03	-5.23	dADP metabolic process	biological process	GO:0046056	2	1	18204	49	AK5
5.376e-03	-5.23	presynapse to nucleus signaling pathway	biological process	GO:0099526	2	1	18204	49	PCLO
5.376e-03	-5.23	olfactory nerve maturation	biological process	GO:0021630	2	1	18204	49	SLC24A4
5.376e-03	-5.23	purine deoxyribonucleoside diphosphate biosynthetic process	biological process	GO:0009183	2	1	18204	49	AK5
5.376e-03	-5.23	polysaccharide localization	biological process	GO:0033037	2	1	18204	49	SMPD3
5.376e-03	-5.23	presynaptic signal transduction	biological process	GO:0098928	2	1	18204	49	PCLO
5.376e-03	-5.23	response to carbon monoxide	biological process	GO:0034465	2	1	18204	49	KCNMA1
5.383e-03	-5.22	protein secretion	biological process	GO:0009306	132	3	18204	49	CPLX1,PCLO,RIMS2
5.392e-03	-5.22	SAM_KSR1_N_sf	interpro domains	IPR046933	2	1	18521	50	KSR2
5.392e-03	-5.22	SAM_KSR1_N	interpro domains	IPR046861	2	1	18521	50	KSR2
5.392e-03	-5.22	Largen/INSYN1	interpro domains	IPR027997	2	1	18521	50	INSYN1
5.392e-03	-5.22	Astrotactin	interpro domains	IPR026995	2	1	18521	50	ASTN1
5.392e-03	-5.22	FOG	interpro domains	IPR039746	2	1	18521	50	ZFPM2
5.392e-03	-5.22	Sph/SMPD2-like	interpro domains	IPR038772	2	1	18521	50	SMPD3
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRG
5.392e-03	-5.22	ASTN1_2_Fn3	interpro domains	IPR045574	2	1	18521	50	ASTN1
5.392e-03	-5.22	ZF_CCHC_FOG	interpro domains	IPR034731	2	1	18521	50	ZFPM2
5.392e-03	-5.22	ZFPM1/2_PR	interpro domains	IPR049361	2	1	18521	50	ZFPM2
5.392e-03	-5.22	Slowpoke-like_C	interpro domains	IPR048735	2	1	18521	50	KCNMA1
5.392e-03	-5.22	IL-1_rcpt_II-typ	interpro domains	IPR004077	2	1	18521	50	IL1RAPL2
5.392e-03	-5.22	AK1/5	interpro domains	IPR006267	2	1	18521	50	AK5
5.392e-03	-5.22	Znf_piccolo	interpro domains	IPR008899	2	1	18521	50	PCLO
5.392e-03	-5.22	Annexin-like	interpro domains	IPR040685	2	1	18521	50	ASTN1
5.392e-03	-5.22	Lgl_C_dom	interpro domains	IPR013905	2	1	18521	50	STXBP5L
5.392e-03	-5.22	ASTN_1_2_N	interpro domains	IPR045575	2	1	18521	50	ASTN1
5.409e-03	-5.22	Circadian entrainment	KEGG pathways	ko04713	96	3	7161	27	CACNA1C,GRIN2A,RYR2
5.409e-03	-5.22	Circadian entrainment	KEGG pathways	hsa04713	96	3	7161	27	RYR2,GRIN2A,CACNA1C
5.409e-03	-5.22	interleukin-1, type II, blocking receptor activity	molecular function	GO:0004910	2	1	18094	49	IL1RAPL2
5.409e-03	-5.22	suramin binding	molecular function	GO:0043924	2	1	18094	49	RYR2
5.409e-03	-5.22	intracellular sodium-activated potassium channel activity	molecular function	GO:0005228	2	1	18094	49	KCNT1
5.409e-03	-5.22	BRE binding	molecular function	GO:0042835	2	1	18094	49	CELF4
5.409e-03	-5.22	large conductance calcium-activated potassium channel activity	molecular function	GO:0060072	2	1	18094	49	KCNMA1
5.443e-03	-5.21	regulation of actin filament-based movement	biological process	GO:1903115	41	2	18204	49	CACNA1C,RYR2
5.476e-03	-5.21	Laminin_G	interpro domains	IPR001791	41	2	18521	50	NRXN3,NRXN1
5.497e-03	-5.20	establishment of protein localization to extracellular region	biological process	GO:0035592	133	3	18204	49	RIMS2,PCLO,CPLX1
5.500e-03	-5.20	Slowpoke_C	pfam domains	PF21014	2	1	17795	49	KCNMA1
5.500e-03	-5.20	Lgl_C	pfam domains	PF08596	2	1	17795	49	STXBP5L
5.500e-03	-5.20	DUF4589	pfam domains	PF15252	2	1	17795	49	INSYN1
5.500e-03	-5.20	FOG1-like_PR	pfam domains	PF21182	2	1	17795	49	ZFPM2
5.500e-03	-5.20	zf-piccolo	pfam domains	PF05715	2	1	17795	49	PCLO
5.500e-03	-5.20	ASTN1_2_fn3	pfam domains	PF19743	2	1	17795	49	ASTN1
5.500e-03	-5.20	Annexin_2	pfam domains	PF18411	2	1	17795	49	ASTN1
5.500e-03	-5.20	SAM_KSR1_N	pfam domains	PF20406	2	1	17795	49	KSR2
5.500e-03	-5.20	ASTN_1_2_N	pfam domains	PF19441	2	1	17795	49	ASTN1
5.707e-03	-5.17	skin-abdomen-malignant_melanoma	COSMIC cancer mutations	skin-abdomen-malignant_melanoma	404	5	16828	48	GABBR2,GRIN2A,ASTN1,RBFOX1,NRXN3
5.800e-03	-5.15	cortisol_and_virilizing_syndrome-producing	COSMIC cancer mutations	cortisol_and_virilizing_syndrome-producing	40	2	16828	48	CACNA1C,GRIN2A
5.880e-03	-5.14	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	6	10285	26	GABRA1,GABRA6,SLC24A4,RYR2,TRPM3,GABRB2
5.885e-03	-5.14	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	40	16828	48	KCNT1,ASTN1,GALNT9,GABRA6,TRPM3,PCLO,CELF5,HCN1,PTPRG,GABRA1,IL1RAPL2,KCNMA1,CELF4,GRIN2A,UNC13C,ZFPM2,NRXN1,LRRC7,GRID2,RYR2,NRXN3,SLC24A4,GABBR2,ZNF804A,KCNIP4,OPRL1,KSR2,CR2,STXBP5L,R3HDM1,ST8SIA5,RGS7,RIMS2,CACNA1C,CPLX1,RIMS4,AK5,OLFM1,MYT1L,GABRD
5.959e-03	-5.12	upper_arm	COSMIC cancer mutations	upper_arm	582	6	16828	48	R3HDM1,GRIN2A,GABRA6,ASTN1,CR2,STXBP5L
5.974e-03	-5.12	regulation of synaptic vesicle exocytosis	biological process	GO:2000300	43	2	18204	49	RIMS4,RIMS2
5.997e-03	-5.12	prostate	COSMIC cancer mutations	prostate	13883	46	16828	48	R3HDM1,ST8SIA5,GABRB2,RIMS2,CPLX1,RIMS4,AK5,GABRD,MYT1L,OLFM1,NRXN3,KCNIP4,GABBR2,CELF6,RBFOX1,STXBP5L,CELF5,GABRA1,IL1RAPL2,CELF4,GRIN2A,UNC13C,ZFPM2,LRRC7,GALNT9,TRPM3,RBFOX3,RGS7,CACNA1C,GRID2,RYR2,ZNF804A,SLC24A4,OPRL1,KSR2,CR2,PCLO,HCN1,PTPRG,KCNMA1,PPP2R5B,NRXN1,KCNT1,ASTN1,GABRA6,SMPD3
6.043e-03	-5.11	cAMP signaling pathway	KEGG pathways	ko04024	198	4	7161	27	CACNA1C,GABBR2,RYR2,GRIN2A
6.043e-03	-5.11	cAMP signaling pathway	KEGG pathways	hsa04024	198	4	7161	27	GABBR2,GRIN2A,RYR2,CACNA1C
6.064e-03	-5.11	ZF_CCHC_FOG	prosite domains	PS51810	2	1	12186	37	ZFPM2
6.081e-03	-5.10	system process	biological process	GO:0003008	2015	12	18204	49	OPRL1,GRID2,SLC24A4,NRXN3,RYR2,NRXN1,CELF4,INSYN1,GRIN2A,KCNMA1,HCN1,CACNA1C
6.110e-03	-5.10	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	8	16828	48	IL1RAPL2,NRXN3,GABRB2,PTPRG,PCLO,RYR2,GRID2,ZFPM2
6.205e-03	-5.08	terminal bouton	cellular component	GO:0043195	46	2	19108	49	CPLX1,UNC13C
6.247e-03	-5.08	receptor localization to synapse	biological process	GO:0097120	44	2	18204	49	DLG3,LRRC7
6.391e-03	-5.05	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	18	16828	48	GABBR2,GABRA6,TRPM3,SMPD3,CR2,GRID2,RYR2,KCNT1,ASTN1,NRXN3,CACNA1C,UNC13C,GRIN2A,OLFM1,LRRC7,HCN1,PCLO,RIMS2
6.398e-03	-5.05	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	37	16828	48	ASTN1,KCNT1,TRPM3,GABRA6,GABRA1,IL1RAPL2,PCLO,HCN1,CELF5,PTPRG,PPP2R5B,NRXN1,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,NRXN3,DLG3,GRID2,RYR2,KSR2,STXBP5L,CR2,GABBR2,ZNF804A,SLC24A4,OPRL1,RGS7,RIMS2,R3HDM1,AK5,MYT1L,GABRD,OLFM1,CACNA1C,CPLX1
6.414e-03	-5.05	learning or memory	biological process	GO:0007611	276	4	18204	49	NRXN3,GRIN2A,OPRL1,NRXN1
6.430e-03	-5.05	middle_third	COSMIC cancer mutations	middle_third	3533	18	16828	48	HCN1,PCLO,RIMS2,CACNA1C,GRIN2A,UNC13C,OLFM1,LRRC7,GRID2,RYR2,KCNT1,ASTN1,NRXN3,GABBR2,GABRA6,TRPM3,CR2,SMPD3
6.461e-03	-5.04	protein localization to extracellular region	biological process	GO:0071692	141	3	18204	49	PCLO,RIMS2,CPLX1
6.472e-03	-5.04	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	37	16828	48	GABRA1,IL1RAPL2,CELF5,HCN1,PCLO,PTPRG,NRXN1,PPP2R5B,LRRC7,CELF4,ZFPM2,UNC13C,GRIN2A,ASTN1,KCNT1,TRPM3,GABRA6,RIMS2,RGS7,R3HDM1,AK5,MYT1L,OLFM1,GABRD,CPLX1,CACNA1C,NRXN3,DLG3,RYR2,GRID2,KSR2,CR2,STXBP5L,GABBR2,SLC24A4,ZNF804A,OPRL1
6.486e-03	-5.04	L1 transposable element, RRM domain	gene3d domains	3.30.70.1820	2	1	14470	47	UNC13C
6.486e-03	-5.04	-	gene3d domains	6.10.140.1120	2	1	14470	47	KSR2
6.503e-03	-5.04	human chr1p31.1	chromosome location	human chr1p31.1	63	2	26134	50	LRRC7,AK5
6.505e-03	-5.04	PPP3CA (protein phosphatase 3 catalytic subunit alpha)	protein interactions	5530	151	3	19454	49	GABRB2,GABRA1,SMPD3
6.511e-03	-5.03	PIGA (phosphatidylinositol glycan anchor biosynthesis class A)	protein interactions	5277	48	2	19454	49	MARCHF4,GRIN2A
6.527e-03	-5.03	glutamate receptor signaling pathway	biological process	GO:0007215	45	2	18204	49	GRIN2A,GRID2
6.527e-03	-5.03	regulation of adenylate cyclase activity	biological process	GO:0045761	45	2	18204	49	GABBR2,CACNA1C
6.527e-03	-5.03	cell communication involved in cardiac conduction	biological process	GO:0086065	45	2	18204	49	RYR2,CACNA1C
6.527e-03	-5.03	cardiac muscle cell action potential involved in contraction	biological process	GO:0086002	45	2	18204	49	CACNA1C,RYR2
6.568e-03	-5.03	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	6	16828	48	PTPRG,RYR2,ZFPM2,CACNA1C,STXBP5L,MYT1L
6.601e-03	-5.02	regulation of neuron projection development	biological process	GO:0010975	443	5	18204	49	LRRC7,PPP2R5B,ZNF804A,GRID2,PTPRG
6.626e-03	-5.02	GnRH Signaling Pathway	SMPDB pathways	SMP0063811	47	2	1369	4	CACNA1C,LRRC7
6.640e-03	-5.01	bone-femur-chondrosarcoma	COSMIC cancer mutations	bone-femur-chondrosarcoma	419	5	16828	48	GABRA6,HCN1,LRRC7,GABRD,STXBP5L
6.663e-03	-5.01	mRNA processing	biological process	GO:0006397	444	5	18204	49	CELF6,RBFOX1,CELF5,RBFOX3,CELF4
6.884e-03	-4.98	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	4	16828	48	PCLO,GABRA6,UNC13C,RBFOX1
6.892e-03	-4.98	pre-mRNA binding	molecular function	GO:0036002	46	2	18094	49	CELF4,CELF5
7.049e-03	-4.95	PTPN4 (protein tyrosine phosphatase non-receptor type 4)	protein interactions	5775	50	2	19454	49	GRID2,GRIN2A
7.053e-03	-4.95	abdomen	COSMIC cancer mutations	abdomen	603	6	16828	48	RBFOX1,GRIN2A,GABBR2,KCNMA1,ASTN1,NRXN3
7.103e-03	-4.95	ventricular cardiac muscle tissue morphogenesis	biological process	GO:0055010	47	2	18204	49	ZFPM2,RYR2
7.221e-03	-4.93	eye	COSMIC cancer mutations	eye	606	6	16828	48	KCNMA1,PCLO,PTPRG,TRPM3,MYT1L,GRIN2A
7.257e-03	-4.93	BKCHANNELA	prints domains	PR01449	2	1	5227	19	KCNMA1
7.257e-03	-4.93	INTRLEUKN1R2	prints domains	PR01539	2	1	5227	19	IL1RAPL2
7.296e-03	-4.92	SNARE complex	cellular component	GO:0031201	50	2	19108	49	STXBP5L,CPLX1
7.519e-03	-4.89	neuromuscular process	biological process	GO:0050905	149	3	18204	49	GRIN2A,NRXN1,GRID2
7.538e-03	-4.89	Vcp (valosin-containing protein)	protein interactions	116643	3	1	19454	49	STXBP5L
7.538e-03	-4.89	SLAMF9 (SLAM family member 9)	protein interactions	89886	3	1	19454	49	INSYN1
7.538e-03	-4.89	Tpm1 (tropomyosin 1)	protein interactions	24851	3	1	19454	49	STXBP5L
7.538e-03	-4.89	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	49	NRXN1
7.538e-03	-4.89	Rps26 (ribosomal protein S26)	protein interactions	27139	3	1	19454	49	STXBP5L
7.538e-03	-4.89	Dlgap2 (DLG associated protein 2)	protein interactions	116681	3	1	19454	49	GRIN2A
7.538e-03	-4.89	Baiap2 (brain-specific angiogenesis inhibitor 1-associated protein 2)	protein interactions	108100	3	1	19454	49	DLG3
7.605e-03	-4.88	ABCA1 (ATP binding cassette subfamily A member 1)	protein interactions	19	52	2	19454	49	DLG3,RIMS2
7.605e-03	-4.88	PKD1 (polycystin 1, transient receptor potential channel interacting)	protein interactions	5310	52	2	19454	49	RGS7,PTPRG
7.674e-03	-4.87	G protein-coupled receptor heterodimeric complex	cellular component	GO:0038039	3	1	19108	49	GABBR2
7.674e-03	-4.87	dendritic microtubule	cellular component	GO:1901588	3	1	19108	49	ZNF804A
7.847e-03	-4.85	cytoplasmic region	cellular component	GO:0099568	307	4	19108	49	RIMS2,PCLO,UNC13C,RIMS4
7.847e-03	-4.85	protein localization to membrane	biological process	GO:0072657	462	5	18204	49	KCNIP4,LRRC7,DLG3,GRIN2A,NRXN1
8.030e-03	-4.82	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	30	16828	48	GALNT9,ASTN1,KCNT1,SMPD3,TRPM3,PTPRG,PCLO,LRRC7,PPP2R5B,NRXN1,UNC13C,GRIN2A,ZFPM2,CELF4,NRXN3,GRID2,RYR2,CELF6,GABBR2,ZNF804A,SLC24A4,KCNIP4,RGS7,ST8SIA5,GABRB2,R3HDM1,MYT1L,OLFM1,AK5,CACNA1C
8.049e-03	-4.82	LamG	smart domains	SM00282	40	2	9717	33	NRXN1,NRXN3
8.054e-03	-4.82	smooth muscle contraction involved in micturition	biological process	GO:0060083	3	1	18204	49	KCNMA1
8.054e-03	-4.82	regulation of SA node cell action potential	biological process	GO:0098907	3	1	18204	49	RYR2
8.054e-03	-4.82	membrane depolarization during atrial cardiac muscle cell action potential	biological process	GO:0098912	3	1	18204	49	CACNA1C
8.054e-03	-4.82	protein localization to early endosome	biological process	GO:1902946	3	1	18204	49	LRRC7
8.054e-03	-4.82	type B pancreatic cell apoptotic process	biological process	GO:0097050	3	1	18204	49	RYR2
8.054e-03	-4.82	directional locomotion	biological process	GO:0033058	3	1	18204	49	GRIN2A
8.054e-03	-4.82	cellular response to redox state	biological process	GO:0071461	3	1	18204	49	SMPD3
8.054e-03	-4.82	response to melanocyte-stimulating hormone	biological process	GO:1990680	3	1	18204	49	SLC24A4
8.054e-03	-4.82	negative regulation of female gonad development	biological process	GO:2000195	3	1	18204	49	ZFPM2
8.054e-03	-4.82	regulation of locomotor rhythm	biological process	GO:1904059	3	1	18204	49	OPRL1
8.054e-03	-4.82	calcium ion transmembrane transport via high voltage-gated calcium channel	biological process	GO:0061577	3	1	18204	49	CACNA1C
8.054e-03	-4.82	right ventricular cardiac muscle tissue morphogenesis	biological process	GO:0003221	3	1	18204	49	ZFPM2
8.054e-03	-4.82	presynaptic active zone assembly	biological process	GO:1904071	3	1	18204	49	PCLO
8.054e-03	-4.82	negative regulation of synaptic plasticity	biological process	GO:0031914	3	1	18204	49	UNC13C
8.054e-03	-4.82	cranial nerve maturation	biological process	GO:0021605	3	1	18204	49	SLC24A4
8.054e-03	-4.82	purine deoxyribonucleoside diphosphate metabolic process	biological process	GO:0009182	3	1	18204	49	AK5
8.054e-03	-4.82	positive regulation of ATPase-coupled calcium transmembrane transporter activity	biological process	GO:1901896	3	1	18204	49	RYR2
8.054e-03	-4.82	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	49	NRXN1
8.054e-03	-4.82	dense core granule priming	biological process	GO:0061789	3	1	18204	49	UNC13C
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR2
8.078e-03	-4.82	MARCHF4/9/11	interpro domains	IPR046356	3	1	18521	50	MARCHF4
8.078e-03	-4.82	Myelin_TF	interpro domains	IPR013681	3	1	18521	50	MYT1L
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR2
8.078e-03	-4.82	AIP/AIPL1/TTC9	interpro domains	IPR039663	3	1	18521	50	TTC9B
8.078e-03	-4.82	NMDAR2_C	interpro domains	IPR018884	3	1	18521	50	GRIN2A
8.078e-03	-4.82	CAC1F_C	interpro domains	IPR031688	3	1	18521	50	CACNA1C
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR2
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR2
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR2
8.078e-03	-4.82	Noelin_dom	interpro domains	IPR022082	3	1	18521	50	OLFM1
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR2
8.078e-03	-4.82	GABAAb_rcpt	interpro domains	IPR002289	3	1	18521	50	GABRB2
8.078e-03	-4.82	GPCR3_GABA-B	interpro domains	IPR002455	3	1	18521	50	GABBR2
8.078e-03	-4.82	Unc-13_C2B	interpro domains	IPR037302	3	1	18521	50	UNC13C
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR2
8.078e-03	-4.82	Unc-13	interpro domains	IPR027080	3	1	18521	50	UNC13C
8.103e-03	-4.82	voltage-gated calcium channel activity involved in AV node cell action potential	molecular function	GO:0086056	3	1	18094	49	CACNA1C
8.103e-03	-4.82	G protein-coupled GABA receptor activity	molecular function	GO:0004965	3	1	18094	49	GABBR2
8.129e-03	-4.81	regulation of monoatomic ion transport	biological process	GO:0043269	466	5	18204	49	CACNA1C,RYR2,GRIN2A,KCNIP4,RGS7
8.238e-03	-4.80	MYT1	pfam domains	PF08474	3	1	17795	49	MYT1L
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR2
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR2
8.238e-03	-4.80	CAC1F_C	pfam domains	PF16885	3	1	17795	49	CACNA1C
8.238e-03	-4.80	NMDAR2_C	pfam domains	PF10565	3	1	17795	49	GRIN2A
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR2
8.238e-03	-4.80	SUZ	pfam domains	PF12752	3	1	17795	49	R3HDM1
8.238e-03	-4.80	Noelin-1	pfam domains	PF12308	3	1	17795	49	OLFM1
8.320e-03	-4.79	cardiac muscle cell contraction	biological process	GO:0086003	51	2	18204	49	RYR2,CACNA1C
8.377e-03	-4.78	regulation of G protein-coupled receptor signaling pathway	biological process	GO:0008277	155	3	18204	49	OPRL1,RGS7,SLC24A4
8.387e-03	-4.78	cell cortex	cellular component	GO:0005938	313	4	19108	49	RIMS4,RIMS2,PCLO,UNC13C
8.477e-03	-4.77	AP4M1 (adaptor related protein complex 4 subunit mu 1)	protein interactions	9179	55	2	19454	49	GRID2,GRIN2A
8.638e-03	-4.75	response to amine	biological process	GO:0014075	52	2	18204	49	GRIN2A,RGS7
8.663e-03	-4.75	cellular localization	biological process	GO:0051641	2660	14	18204	49	DLG3,GRIN2A,KCNIP4,RYR2,RIMS4,PCLO,HCN1,CPLX1,STXBP5L,UNC13C,RIMS2,NRXN1,GRID2,LRRC7
8.746e-03	-4.74	Felodipine Metabolism Pathway	SMPDB pathways	SMP0000619	3	1	1369	4	CACNA1C
8.962e-03	-4.71	biological process involved in intraspecies interaction between organisms	biological process	GO:0051703	53	2	18204	49	NRXN3,NRXN1
8.962e-03	-4.71	social behavior	biological process	GO:0035176	53	2	18204	49	NRXN1,NRXN3
9.290e-03	-4.68	positive regulation of neuron projection development	biological process	GO:0010976	161	3	18204	49	PPP2R5B,ZNF804A,LRRC7
9.290e-03	-4.68	regulation of cyclase activity	biological process	GO:0031279	54	2	18204	49	CACNA1C,GABBR2
9.390e-03	-4.67	GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B)	protein interactions	2904	58	2	19454	49	GRIN2A,DLG3
9.391e-03	-4.67	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	46	16828	48	AK5,MYT1L,GABRD,CPLX1,RIMS4,ST8SIA5,GABRB2,RIMS2,R3HDM1,RBFOX1,STXBP5L,GABBR2,KCNIP4,CELF6,TTC9B,NRXN3,DLG3,LRRC7,CELF4,UNC13C,GRIN2A,ZFPM2,IL1RAPL2,GABRA1,CELF5,TRPM3,GALNT9,CACNA1C,RGS7,KSR2,CR2,ZNF804A,SLC24A4,OPRL1,RYR2,GRID2,PPP2R5B,NRXN1,KCNMA1,PCLO,HCN1,PTPRG,SMPD3,GABRA6,ASTN1,KCNT1
9.565e-03	-4.65	regulation of transmembrane transport	biological process	GO:0034762	485	5	18204	49	RYR2,GRIN2A,RGS7,KCNIP4,CACNA1C
9.625e-03	-4.64	establishment or maintenance of epithelial cell apical/basal polarity	biological process	GO:0045197	55	2	18204	49	LRRC7,DLG3
9.686e-03	-4.64	Penbutolol Action Pathway	SMPDB pathways	SMP0000305	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Fosphenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000326	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Dobutamine Action Pathway	SMPDB pathways	SMP0000662	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Bopindolol Action Pathway	SMPDB pathways	SMP0000657	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Oxprenolol Action Pathway	SMPDB pathways	SMP0000304	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Verapamil Action Pathway	SMPDB pathways	SMP0000375	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Ibutilide Action Pathway	SMPDB pathways	SMP0000332	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Metipranolol Action Pathway	SMPDB pathways	SMP0000667	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Amlodipine Action Pathway	SMPDB pathways	SMP0000376	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Procainamide (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000324	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Timolol Action Pathway	SMPDB pathways	SMP0000659	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Atenolol Action Pathway	SMPDB pathways	SMP0000298	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Diltiazem Action Pathway	SMPDB pathways	SMP0000359	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Disopyramide Action Pathway	SMPDB pathways	SMP0000325	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Isradipine Action Pathway	SMPDB pathways	SMP0000378	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Pindolol Action Pathway	SMPDB pathways	SMP0000306	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Acebutolol Action Pathway	SMPDB pathways	SMP0000296	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Isoprenaline Action Pathway	SMPDB pathways	SMP0000663	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Esmolol Action Pathway	SMPDB pathways	SMP0000301	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Bupranolol Action Pathway	SMPDB pathways	SMP0000670	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Bisoprolol Action Pathway	SMPDB pathways	SMP0000300	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Nitrendipine Action Pathway	SMPDB pathways	SMP0000382	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Practolol Action Pathway	SMPDB pathways	SMP0000669	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Nifedipine Action Pathway	SMPDB pathways	SMP0000379	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Flecainide Action Pathway	SMPDB pathways	SMP0000331	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Carteolol Action Pathway	SMPDB pathways	SMP0000658	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Sotalol Action Pathway	SMPDB pathways	SMP0000660	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Betaxolol Action Pathway	SMPDB pathways	SMP0000299	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Levobunolol Action Pathway	SMPDB pathways	SMP0000666	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Nadolol Action Pathway	SMPDB pathways	SMP0000303	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Epinephrine Action Pathway	SMPDB pathways	SMP0000661	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Tocainide Action Pathway	SMPDB pathways	SMP0000330	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Bevantolol Action Pathway	SMPDB pathways	SMP0000668	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Muscle/Heart Contraction	SMPDB pathways	SMP0000588	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Nebivolol Action Pathway	SMPDB pathways	SMP0000366	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Alprenolol Action Pathway	SMPDB pathways	SMP0000297	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Propranolol Action Pathway	SMPDB pathways	SMP0000307	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Mexiletine Action Pathway	SMPDB pathways	SMP0000329	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Nisoldipine Action Pathway	SMPDB pathways	SMP0000381	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Felodipine Action Pathway	SMPDB pathways	SMP0000377	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Metoprolol Action Pathway	SMPDB pathways	SMP0000302	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Nimodipine Action Pathway	SMPDB pathways	SMP0000380	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Arbutamine Action Pathway	SMPDB pathways	SMP0000664	57	2	1369	4	CACNA1C,RYR2
9.686e-03	-4.64	Amiodarone Action Pathway	SMPDB pathways	SMP0000665	57	2	1369	4	RYR2,CACNA1C
9.686e-03	-4.64	Quinidine Action Pathway	SMPDB pathways	SMP0000323	57	2	1369	4	CACNA1C,RYR2
9.713e-03	-4.63	Single Helix bin	gene3d domains	1.20.5.580	3	1	14470	47	CPLX1
9.713e-03	-4.63	-	gene3d domains	1.10.490.160	3	1	14470	47	RYR2
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	GRIN2A,GRID2,ZNF804A
9.964e-03	-4.61	cardiac muscle cell action potential	biological process	GO:0086001	56	2	18204	49	CACNA1C,RYR2
1.001e-02	-4.60	central_nervous_system-posterior_fossa-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-posterior_fossa-glioma-astrocytoma_Grade_IV	53	2	16828	48	STXBP5L,LRRC7
1.002e-02	-4.60	Carvedilol Action Pathway	SMPDB pathways	SMP0000367	58	2	1369	4	RYR2,CACNA1C
1.002e-02	-4.60	Labetalol Action Pathway	SMPDB pathways	SMP0000368	58	2	1369	4	RYR2,CACNA1C
1.003e-02	-4.60	regulation of transport	biological process	GO:0051049	1621	10	18204	49	CPLX1,CACNA1C,RYR2,RIMS2,GRIN2A,KCNIP4,SMPD3,RIMS4,PCLO,RGS7
1.004e-02	-4.60	Sstr2 (somatostatin receptor 2)	protein interactions	54305	4	1	19454	49	DLG3
1.004e-02	-4.60	Clta (clathrin, light chain A)	protein interactions	83800	4	1	19454	49	STXBP5L
1.004e-02	-4.60	HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)	protein interactions	10021	4	1	19454	49	HCN1
1.004e-02	-4.60	Map1b (microtubule-associated protein 1B)	protein interactions	29456	4	1	19454	49	STXBP5L
1.004e-02	-4.60	Psmc5 (proteasome 26S subunit, ATPase 5)	protein interactions	81827	4	1	19454	49	STXBP5L
1.004e-02	-4.60	NUDT16L2P (nudix hydrolase 16 like 2, pseudogene)	protein interactions	152195	4	1	19454	49	GRIN2A
1.004e-02	-4.60	Ywhaq (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta)	protein interactions	25577	4	1	19454	49	STXBP5L
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	ZNF804A,GRID2,GRIN2A
1.007e-02	-4.60	HCN channels	REACTOME pathways	R-HSA-1296061	4	1	10285	26	HCN1
1.017e-02	-4.59	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	298	4	16828	48	NRXN3,PPP2R5B,GABRA1,PCLO
1.022e-02	-4.58	HCN channel complex	cellular component	GO:0098855	4	1	19108	49	HCN1
1.027e-02	-4.58	nervous system process	biological process	GO:0050877	1376	9	18204	49	OPRL1,NRXN3,SLC24A4,GRID2,INSYN1,CELF4,GRIN2A,NRXN1,HCN1
1.036e-02	-4.57	Lidocaine (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000328	59	2	1369	4	RYR2,CACNA1C
1.037e-02	-4.57	neuron projection membrane	cellular component	GO:0032589	60	2	19108	49	GABRA1,GABRA6
1.055e-02	-4.55	cognition	biological process	GO:0050890	319	4	18204	49	NRXN3,NRXN1,OPRL1,GRIN2A
1.066e-02	-4.54	regulation of lyase activity	biological process	GO:0051339	58	2	18204	49	CACNA1C,GABBR2
1.072e-02	-4.54	negative regulation of hyaluronan biosynthetic process	biological process	GO:1900126	4	1	18204	49	SMPD3
1.072e-02	-4.54	response to high light intensity	biological process	GO:0009644	4	1	18204	49	SLC24A4
1.072e-02	-4.54	cellular response to light intensity	biological process	GO:0071484	4	1	18204	49	SLC24A4
1.072e-02	-4.54	maintenance of presynaptic active zone structure	biological process	GO:0048790	4	1	18204	49	PCLO
1.072e-02	-4.54	left ventricular cardiac muscle tissue morphogenesis	biological process	GO:0003220	4	1	18204	49	RYR2
1.072e-02	-4.54	deoxyribonucleoside diphosphate biosynthetic process	biological process	GO:0009189	4	1	18204	49	AK5
1.072e-02	-4.54	regulation of atrial cardiac muscle cell action potential	biological process	GO:0098910	4	1	18204	49	RYR2
1.072e-02	-4.54	nerve maturation	biological process	GO:0021682	4	1	18204	49	SLC24A4
1.072e-02	-4.54	negative regulation of gonad development	biological process	GO:1905940	4	1	18204	49	ZFPM2
1.072e-02	-4.54	regulation of AV node cell action potential	biological process	GO:0098904	4	1	18204	49	RYR2
1.076e-02	-4.53	VDCC_L_a1su	interpro domains	IPR005446	4	1	18521	50	CACNA1C
1.076e-02	-4.53	DLG1-like	interpro domains	IPR016313	4	1	18521	50	DLG3
1.076e-02	-4.53	RGS6/7/9/11_DHEX_sf	interpro domains	IPR047017	4	1	18521	50	RGS7
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	DLG1-4_PDZ_assoc	interpro domains	IPR019583	4	1	18521	50	DLG3
1.076e-02	-4.53	RGS6/7/9/11	interpro domains	IPR047016	4	1	18521	50	RGS7
1.076e-02	-4.53	Lethal2_giant	interpro domains	IPR000664	4	1	18521	50	STXBP5L
1.076e-02	-4.53	SUZ	interpro domains	IPR024771	4	1	18521	50	R3HDM1
1.076e-02	-4.53	LLGL2	interpro domains	IPR013577	4	1	18521	50	STXBP5L
1.076e-02	-4.53	RGS_DHEX	interpro domains	IPR040759	4	1	18521	50	RGS7
1.076e-02	-4.53	Synaphin	interpro domains	IPR008849	4	1	18521	50	CPLX1
1.076e-02	-4.53	Opioid_rcpt	interpro domains	IPR001418	4	1	18521	50	OPRL1
1.076e-02	-4.53	DLG1_PEST_dom	interpro domains	IPR019590	4	1	18521	50	DLG3
1.076e-02	-4.53	Ion_trans_N	interpro domains	IPR013621	4	1	18521	50	HCN1
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	response to organonitrogen compound	biological process	GO:0010243	915	7	18204	49	GABRB2,HCN1,RYR2,GRIN2A,SMPD3,SLC24A4,RGS7
1.079e-02	-4.53	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	49	RYR2
1.079e-02	-4.53	structural constituent of presynaptic active zone	molecular function	GO:0098882	4	1	18094	49	PCLO
1.084e-02	-4.52	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	47	16828	48	NRXN3,DLG3,GABBR2,KCNIP4,TTC9B,CELF6,RBFOX1,STXBP5L,R3HDM1,GABRB2,ST8SIA5,RIMS2,RIMS4,AK5,MYT1L,GABRD,OLFM1,GALNT9,TRPM3,CELF5,GABRA1,IL1RAPL2,CELF4,ZFPM2,UNC13C,GRIN2A,LRRC7,GRID2,RYR2,SLC24A4,ZNF804A,OPRL1,KSR2,CR2,RBFOX3,RGS7,CACNA1C,KCNT1,ASTN1,GABRA6,SMPD3,HCN1,PCLO,PTPRG,KCNMA1,NRXN1,PPP2R5B
1.087e-02	-4.52	GABABRECEPTR	prints domains	PR01176	3	1	5227	19	GABBR2
1.087e-02	-4.52	RYANODINER	prints domains	PR00795	3	1	5227	19	RYR2
1.087e-02	-4.52	GABAARBETA	prints domains	PR01160	3	1	5227	19	GABRB2
1.097e-02	-4.51	Synaphin	pfam domains	PF05835	4	1	17795	49	CPLX1
1.097e-02	-4.51	Ion_trans_N	pfam domains	PF08412	4	1	17795	49	HCN1
1.097e-02	-4.51	TRPM_tetra	pfam domains	PF16519	4	1	17795	49	TRPM3
1.097e-02	-4.51	LLGL	pfam domains	PF08366	4	1	17795	49	STXBP5L
1.097e-02	-4.51	PDZ_assoc	pfam domains	PF10600	4	1	17795	49	DLG3
1.097e-02	-4.51	RGS_DHEX	pfam domains	PF18148	4	1	17795	49	RGS7
1.101e-02	-4.51	Axon guidance	REACTOME pathways	R-HSA-422475	549	5	10285	26	PPP2R5B,CACNA1C,DLG3,GRIN2A,KSR2
1.101e-02	-4.51	establishment or maintenance of apical/basal cell polarity	biological process	GO:0035088	59	2	18204	49	LRRC7,DLG3
1.101e-02	-4.51	establishment or maintenance of bipolar cell polarity	biological process	GO:0061245	59	2	18204	49	LRRC7,DLG3
1.106e-02	-4.50	bladder	COSMIC cancer mutations	bladder	14112	46	16828	48	KCNIP4,GABBR2,CELF6,TTC9B,RBFOX1,STXBP5L,NRXN3,DLG3,CPLX1,RIMS4,AK5,MYT1L,GABRD,R3HDM1,ST8SIA5,GABRB2,RIMS2,TRPM3,GALNT9,CELF4,UNC13C,GRIN2A,ZFPM2,LRRC7,CELF5,GABRA1,IL1RAPL2,SLC24A4,ZNF804A,OPRL1,KSR2,CR2,RYR2,GRID2,CACNA1C,RGS7,GABRA6,SMPD3,KCNT1,ASTN1,PPP2R5B,NRXN1,PCLO,HCN1,PTPRG,KCNMA1
1.106e-02	-4.50	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	46	16828	48	DLG3,NRXN3,CELF6,TTC9B,KCNIP4,GABBR2,STXBP5L,RBFOX1,R3HDM1,RIMS2,GABRB2,ST8SIA5,RIMS4,CPLX1,GABRD,MYT1L,AK5,GALNT9,TRPM3,CELF5,GABRA1,IL1RAPL2,ZFPM2,UNC13C,GRIN2A,CELF4,LRRC7,GRID2,RYR2,OPRL1,SLC24A4,ZNF804A,CR2,KSR2,RGS7,CACNA1C,KCNT1,ASTN1,GABRA6,SMPD3,PTPRG,HCN1,PCLO,KCNMA1,NRXN1,PPP2R5B
1.127e-02	-4.49	Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3	KEGG pathways	M00069	3	1	7161	27	ST8SIA5
1.127e-02	-4.49	Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3	KEGG pathways	hsa_M00069	3	1	7161	27	ST8SIA5
1.137e-02	-4.48	regulation of action potential	biological process	GO:0098900	60	2	18204	49	CACNA1C,RYR2
1.144e-02	-4.47	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	17	RGS7,CACNA1C,RYR2
1.156e-02	-4.46	liver-carcinoma	COSMIC cancer mutations	liver-carcinoma	15337	48	16828	48	KCNT1,ASTN1,GABRA6,SMPD3,PCLO,HCN1,PTPRG,KCNMA1,PPP2R5B,NRXN1,RYR2,GRID2,ZNF804A,SLC24A4,OPRL1,KSR2,CR2,RGS7,RBFOX3,CACNA1C,GALNT9,TRPM3,CELF5,IL1RAPL2,GABRA1,CELF4,GRIN2A,UNC13C,ZFPM2,LRRC7,NRXN3,DLG3,GABBR2,KCNIP4,CELF6,TTC9B,RBFOX1,STXBP5L,R3HDM1,ST8SIA5,GABRB2,RIMS2,CPLX1,RIMS4,AK5,GABRD,MYT1L,OLFM1
1.165e-02	-4.45	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	17	CPLX1,UNC13C
1.166e-02	-4.45	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	42	16828	48	GALNT9,ASTN1,KCNT1,SMPD3,TRPM3,GABRA6,GABRA1,IL1RAPL2,KCNMA1,PTPRG,PCLO,CELF5,HCN1,LRRC7,NRXN1,UNC13C,GRIN2A,ZFPM2,CELF4,NRXN3,GRID2,RYR2,CR2,STXBP5L,KSR2,RBFOX1,TTC9B,KCNIP4,ZNF804A,GABBR2,RBFOX3,RGS7,RIMS2,ST8SIA5,GABRB2,R3HDM1,OLFM1,MYT1L,AK5,RIMS4,CACNA1C,CPLX1
1.174e-02	-4.44	cardiac muscle tissue morphogenesis	biological process	GO:0055008	61	2	18204	49	RYR2,ZFPM2
1.174e-02	-4.44	negative regulation of G protein-coupled receptor signaling pathway	biological process	GO:0045744	61	2	18204	49	RGS7,OPRL1
1.178e-02	-4.44	cellular component assembly	biological process	GO:0022607	2472	13	18204	49	GRID2,SMPD3,GABRA6,CELF6,NRXN1,UNC13C,GABRB2,HCN1,TRPM3,PCLO,GABRA1,CELF4,CELF5
1.181e-02	-4.44	C1-like_sf	interpro domains	IPR046349	61	2	18521	50	KSR2,UNC13C
1.209e-02	-4.42	excitatory synapse	cellular component	GO:0060076	65	2	19108	49	UNC13C,GRID2
1.209e-02	-4.42	SUZ	prosite domains	PS51673	4	1	12186	37	R3HDM1
1.211e-02	-4.41	regulation of postsynaptic membrane neurotransmitter receptor levels	biological process	GO:0099072	62	2	18204	49	DLG3,LRRC7
1.227e-02	-4.40	regulation of vesicle-mediated transport	biological process	GO:0060627	516	5	18204	49	CPLX1,SMPD3,RIMS4,PCLO,RIMS2
1.238e-02	-4.39	PCNX3 (pecanex 3)	protein interactions	399909	67	2	19454	49	GABRA6,MARCHF4
1.244e-02	-4.39	Dopaminergic synapse	KEGG pathways	hsa04728	130	3	7161	27	CACNA1C,PPP2R5B,GRIN2A
1.244e-02	-4.39	Dopaminergic synapse	KEGG pathways	ko04728	130	3	7161	27	GRIN2A,PPP2R5B,CACNA1C
1.249e-02	-4.38	ventricular cardiac muscle tissue development	biological process	GO:0003229	63	2	18204	49	RYR2,ZFPM2
1.253e-02	-4.38	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	49	TRPM3
1.253e-02	-4.38	TRH (thyrotropin releasing hormone)	protein interactions	7200	5	1	19454	49	KCNIP4
1.253e-02	-4.38	Ncam1 (neural cell adhesion molecule 1)	protein interactions	24586	5	1	19454	49	STXBP5L
1.253e-02	-4.38	GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3)	protein interactions	2567	5	1	19454	49	GABRA1
1.253e-02	-4.38	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	49	NRXN1
1.253e-02	-4.38	NXNL2 (nucleoredoxin like 2)	protein interactions	158046	5	1	19454	49	GRIN2A
1.253e-02	-4.38	CHRM1 (cholinergic receptor muscarinic 1)	protein interactions	1128	5	1	19454	49	RGS7
1.253e-02	-4.38	HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)	protein interactions	57657	5	1	19454	49	HCN1
1.258e-02	-4.38	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	7	16828	48	GABBR2,CELF4,PTPRG,ASTN1,AK5,MYT1L,LRRC7
1.274e-02	-4.36	TMEM186 (transmembrane protein 186)	protein interactions	25880	68	2	19454	49	MARCHF4,OPRL1
1.275e-02	-4.36	Nicotine Activity on Chromaffin Cells	WikiPathways	WP1603	4	1	5310	17	CACNA1C
1.281e-02	-4.36	skin-upper_back-malignant_melanoma	COSMIC cancer mutations	skin-upper_back-malignant_melanoma	319	4	16828	48	RGS7,KCNIP4,GRIN2A,GABRA6
1.293e-02	-4.35	-	gene3d domains	1.20.58.1100	4	1	14470	47	UNC13C
1.293e-02	-4.35	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	47	TRPM3
1.293e-02	-4.35	-	gene3d domains	1.10.1240.60	4	1	14470	47	RGS7
1.308e-02	-4.34	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	4	16828	48	PPP2R5B,NRXN3,GABRA1,PCLO
1.325e-02	-4.32	positive regulation of synapse assembly	biological process	GO:0051965	65	2	18204	49	GRID2,NRXN1
1.325e-02	-4.32	sensory perception of pain	biological process	GO:0019233	65	2	18204	49	OPRL1,GRIN2A
1.333e-02	-4.32	ZF_DAG_PE_1	prosite domains	PS00479	58	2	12186	37	KSR2,UNC13C
1.339e-02	-4.31	presynaptic dense core vesicle exocytosis	biological process	GO:0099525	5	1	18204	49	UNC13C
1.339e-02	-4.31	calcium ion export across plasma membrane	biological process	GO:1990034	5	1	18204	49	SLC24A4
1.339e-02	-4.31	neuronal dense core vesicle exocytosis	biological process	GO:0099011	5	1	18204	49	UNC13C
1.339e-02	-4.31	membrane depolarization during AV node cell action potential	biological process	GO:0086045	5	1	18204	49	CACNA1C
1.339e-02	-4.31	conditioned place preference	biological process	GO:1990708	5	1	18204	49	OPRL1
1.339e-02	-4.31	neuron-glial cell signaling	biological process	GO:0150099	5	1	18204	49	GABBR2
1.339e-02	-4.31	Purkinje myocyte to ventricular cardiac muscle cell signaling	biological process	GO:0086029	5	1	18204	49	RYR2
1.339e-02	-4.31	deoxyribonucleoside diphosphate metabolic process	biological process	GO:0009186	5	1	18204	49	AK5
1.339e-02	-4.31	positive regulation of neurotrophin TRK receptor signaling pathway	biological process	GO:0051388	5	1	18204	49	PPP2R5B
1.339e-02	-4.31	negative regulation of cell volume	biological process	GO:0045794	5	1	18204	49	KCNMA1
1.339e-02	-4.31	regulation of homophilic cell adhesion	biological process	GO:1903385	5	1	18204	49	PTPRG
1.339e-02	-4.31	ADP biosynthetic process	biological process	GO:0006172	5	1	18204	49	AK5
1.339e-02	-4.31	response to odorant	biological process	GO:1990834	5	1	18204	49	SLC24A4
1.339e-02	-4.31	purine deoxyribonucleotide biosynthetic process	biological process	GO:0009153	5	1	18204	49	AK5
1.339e-02	-4.31	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	49	ZNF804A
1.339e-02	-4.31	positive regulation of the force of heart contraction	biological process	GO:0098735	5	1	18204	49	RYR2
1.339e-02	-4.31	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	49	NRXN1
1.339e-02	-4.31	general adaptation syndrome, behavioral process	biological process	GO:0051867	5	1	18204	49	HCN1
1.343e-02	-4.31	PP2A_B56	interpro domains	IPR002554	5	1	18521	50	PPP2R5B
1.343e-02	-4.31	Znf_C2H2C_sf	interpro domains	IPR036060	5	1	18521	50	MYT1L
1.343e-02	-4.31	K/Na/Ca-exchanger	interpro domains	IPR004481	5	1	18521	50	SLC24A4
1.343e-02	-4.31	Munc13_dom-2	interpro domains	IPR014772	5	1	18521	50	UNC13C
1.347e-02	-4.31	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	molecular function	GO:0086007	5	1	18094	49	CACNA1C
1.347e-02	-4.31	calcium, potassium:sodium antiporter activity	molecular function	GO:0008273	5	1	18094	49	SLC24A4
1.347e-02	-4.31	extraskeletal	COSMIC cancer mutations	extraskeletal	903	7	16828	48	ASTN1,PTPRG,LRRC7,MYT1L,AK5,CELF4,GABBR2
1.352e-02	-4.30	MAGUK_N_PEST	smart domains	SM01277	4	1	9717	33	DLG3
1.369e-02	-4.29	B56	pfam domains	PF01603	5	1	17795	49	PPP2R5B
1.372e-02	-4.29	PE/DAG-bd	interpro domains	IPR002219	66	2	18521	50	UNC13C,KSR2
1.392e-02	-4.27	calcium channel complex	cellular component	GO:0034704	70	2	19108	49	RYR2,CACNA1C
1.406e-02	-4.26	upper_back	COSMIC cancer mutations	upper_back	328	4	16828	48	RGS7,KCNIP4,GABRA6,GRIN2A
1.429e-02	-4.25	Muscle contraction	REACTOME pathways	R-HSA-397014	204	3	10285	26	KCNIP4,CACNA1C,RYR2
1.432e-02	-4.25	RBM47 (RNA binding motif protein 47)	protein interactions	54502	202	3	19454	49	CELF5,RBFOX1,R3HDM1
1.446e-02	-4.24	LVDCCALPHA1	prints domains	PR01630	4	1	5227	19	CACNA1C
1.446e-02	-4.24	LETHAL2GIANT	prints domains	PR00962	4	1	5227	19	STXBP5L
1.446e-02	-4.24	OPIOIDR	prints domains	PR00384	4	1	5227	19	OPRL1
1.458e-02	-4.23	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	47	16828	48	LRRC7,ZFPM2,GRIN2A,UNC13C,CELF4,GABRA1,IL1RAPL2,CELF5,TRPM3,GALNT9,OLFM1,GABRD,MYT1L,AK5,RIMS4,CPLX1,RIMS2,GABRB2,ST8SIA5,R3HDM1,STXBP5L,RBFOX1,CELF6,TTC9B,GABBR2,DLG3,NRXN3,NRXN1,PPP2R5B,KCNMA1,PTPRG,HCN1,PCLO,SMPD3,GABRA6,ASTN1,KCNT1,CACNA1C,RGS7,RBFOX3,CR2,KSR2,OPRL1,SLC24A4,ZNF804A,RYR2,GRID2
1.502e-02	-4.20	GRID2IP (Grid2 interacting protein)	protein interactions	392862	6	1	19454	49	GRID2
1.502e-02	-4.20	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	49	NRXN1
1.502e-02	-4.20	Tubb4b (tubulin, beta 4B class IVb)	protein interactions	296554	6	1	19454	49	STXBP5L
1.508e-02	-4.19	TNFR1-mediated ceramide production	REACTOME pathways	R-HSA-5626978	6	1	10285	26	SMPD3
1.509e-02	-4.19	MHD2	prosite domains	PS51259	5	1	12186	37	UNC13C
1.516e-02	-4.19	meninges	COSMIC cancer mutations	meninges	514	5	16828	48	CR2,RIMS2,GRIN2A,CACNA1C,PCLO
1.516e-02	-4.19	meningioma	COSMIC cancer mutations	meningioma	514	5	16828	48	GRIN2A,CACNA1C,PCLO,RIMS2,CR2
1.526e-02	-4.18	cardiac conduction	biological process	GO:0061337	70	2	18204	49	RYR2,CACNA1C
1.526e-02	-4.18	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	46	16828	48	KCNT1,ASTN1,GABRA6,SMPD3,PTPRG,HCN1,PCLO,KCNMA1,NRXN1,PPP2R5B,GRID2,RYR2,OPRL1,ZNF804A,SLC24A4,CR2,KSR2,RBFOX3,RGS7,CACNA1C,GALNT9,TRPM3,CELF5,IL1RAPL2,GABRA1,ZFPM2,UNC13C,GRIN2A,CELF4,LRRC7,DLG3,NRXN3,CELF6,TTC9B,GABBR2,STXBP5L,RBFOX1,R3HDM1,RIMS2,GABRB2,ST8SIA5,RIMS4,GABRD,MYT1L,OLFM1,AK5
1.529e-02	-4.18	nuclear stress granule	cellular component	GO:0097165	6	1	19108	49	RBFOX1
1.529e-02	-4.18	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	3	16828	48	ZNF804A,GRID2,PTPRG
1.554e-02	-4.16	central_nervous_system-brainstem-glioma	COSMIC cancer mutations	central_nervous_system-brainstem-glioma	338	4	16828	48	IL1RAPL2,ASTN1,OPRL1,CELF4
1.560e-02	-4.16	ZF_DAG_PE_2	prosite domains	PS50081	63	2	12186	37	KSR2,UNC13C
1.562e-02	-4.16	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	25	16828	48	RIMS4,RIMS2,GABRB2,OPRL1,TTC9B,SLC24A4,ZNF804A,KCNIP4,CR2,STXBP5L,RBFOX1,GRID2,NRXN3,CELF4,LRRC7,PPP2R5B,NRXN1,CELF5,HCN1,IL1RAPL2,KCNMA1,GABRA6,SMPD3,TRPM3,ASTN1
1.569e-02	-4.16	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	25	16828	48	KCNMA1,IL1RAPL2,HCN1,CELF5,LRRC7,NRXN1,PPP2R5B,CELF4,ASTN1,SMPD3,TRPM3,GABRA6,RIMS2,GABRB2,RIMS4,NRXN3,GRID2,STXBP5L,CR2,RBFOX1,TTC9B,OPRL1,SLC24A4,ZNF804A,KCNIP4
1.569e-02	-4.15	pharynx	COSMIC cancer mutations	pharynx	2696	14	16828	48	RYR2,ASTN1,NRXN3,SLC24A4,RBFOX1,CR2,HCN1,PCLO,PTPRG,RGS7,ZFPM2,GRIN2A,GABRD,MYT1L
1.573e-02	-4.15	SDR9C7 (short chain dehydrogenase/reductase family 9C member 7)	protein interactions	121214	76	2	19454	49	RBFOX1,GALNT9
1.573e-02	-4.15	SRI (sorcin)	protein interactions	6717	76	2	19454	49	RYR2,CACNA1C
1.573e-02	-4.15	caecum	COSMIC cancer mutations	caecum	14248	46	16828	48	CELF5,GABRA1,IL1RAPL2,ZFPM2,UNC13C,GRIN2A,CELF4,LRRC7,GALNT9,TRPM3,R3HDM1,RIMS2,GABRB2,ST8SIA5,RIMS4,OLFM1,GABRD,MYT1L,AK5,DLG3,NRXN3,TTC9B,CELF6,GABBR2,STXBP5L,RBFOX1,PTPRG,HCN1,PCLO,KCNMA1,NRXN1,PPP2R5B,KCNT1,ASTN1,GABRA6,SMPD3,RGS7,RBFOX3,CACNA1C,GRID2,RYR2,OPRL1,SLC24A4,ZNF804A,CR2,KSR2
1.587e-02	-4.14	neuromuscular junction	cellular component	GO:0031594	75	2	19108	49	DLG3,UNC13C
1.591e-02	-4.14	regulation of secretion by cell	biological process	GO:1903530	551	5	18204	49	RIMS2,RIMS4,PCLO,SMPD3,CPLX1
1.604e-02	-4.13	positive regulation of inhibitory postsynaptic potential	biological process	GO:0097151	6	1	18204	49	RIMS2
1.604e-02	-4.13	vocal learning	biological process	GO:0042297	6	1	18204	49	NRXN1
1.604e-02	-4.13	neuronal signal transduction	biological process	GO:0023041	6	1	18204	49	OLFM1
1.604e-02	-4.13	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	1	18204	49	NRXN1
1.604e-02	-4.13	Purkinje myocyte to ventricular cardiac muscle cell communication	biological process	GO:0086068	6	1	18204	49	RYR2
1.604e-02	-4.13	purine nucleoside diphosphate biosynthetic process	biological process	GO:0009136	6	1	18204	49	AK5
1.604e-02	-4.13	purine ribonucleoside diphosphate biosynthetic process	biological process	GO:0009180	6	1	18204	49	AK5
1.604e-02	-4.13	general adaptation syndrome	biological process	GO:0051866	6	1	18204	49	HCN1
1.604e-02	-4.13	imitative learning	biological process	GO:0098596	6	1	18204	49	NRXN1
1.604e-02	-4.13	dentinogenesis	biological process	GO:0097187	6	1	18204	49	SMPD3
1.604e-02	-4.13	cellular response to histamine	biological process	GO:0071420	6	1	18204	49	GABRB2
1.604e-02	-4.13	presynaptic active zone organization	biological process	GO:1990709	6	1	18204	49	PCLO
1.604e-02	-4.13	sphingomyelin catabolic process	biological process	GO:0006685	6	1	18204	49	SMPD3
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR2
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR2
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR2
1.609e-02	-4.13	Adenylat_kinase_CS	interpro domains	IPR033690	6	1	18521	50	AK5
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR2
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR2
1.609e-02	-4.13	cardiac ventricle morphogenesis	biological process	GO:0003208	72	2	18204	49	ZFPM2,RYR2
1.614e-02	-4.13	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	49	RYR2
1.614e-02	-4.13	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	molecular function	GO:0003828	6	1	18094	49	ST8SIA5
1.614e-02	-4.13	glutamate-gated calcium ion channel activity	molecular function	GO:0022849	6	1	18094	49	GRIN2A
1.636e-02	-4.11	Adrenergic signaling in cardiomyocytes	KEGG pathways	ko04261	144	3	7161	27	PPP2R5B,RYR2,CACNA1C
1.636e-02	-4.11	Adrenergic signaling in cardiomyocytes	KEGG pathways	hsa04261	144	3	7161	27	CACNA1C,PPP2R5B,RYR2
1.641e-02	-4.11	zf-C2HC	pfam domains	PF01530	6	1	17795	49	MYT1L
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	RYR2
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	RYR2
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	RYR2
1.662e-02	-4.10	protein-RNA complex assembly	biological process	GO:0022618	200	3	18204	49	CELF6,CELF5,CELF4
1.687e-02	-4.08	DUF1041	smart domains	SM01145	5	1	9717	33	UNC13C
1.693e-02	-4.08	PKD2 (polycystin 2, transient receptor potential cation channel)	protein interactions	5311	79	2	19454	49	PTPRG,INSYN1
1.738e-02	-4.05	muscle tissue morphogenesis	biological process	GO:0060415	75	2	18204	49	RYR2,ZFPM2
1.738e-02	-4.05	regulation of behavior	biological process	GO:0050795	75	2	18204	49	SLC24A4,OPRL1
1.738e-02	-4.05	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	biological process	GO:0007193	75	2	18204	49	GABBR2,OPRL1
1.740e-02	-4.05	Phenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000327	77	2	1369	4	CACNA1C,RYR2
1.750e-02	-4.05	CR1 (complement C3b/C4b receptor 1 (Knops blood group))	protein interactions	1378	7	1	19454	49	CR2
1.750e-02	-4.05	KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1)	protein interactions	3779	7	1	19454	49	KCNMA1
1.750e-02	-4.05	HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)	protein interactions	610	7	1	19454	49	HCN1
1.750e-02	-4.05	KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2)	protein interactions	9992	7	1	19454	49	CACNA1C
1.757e-02	-4.04	Phase 1 - inactivation of fast Na+ channels	REACTOME pathways	R-HSA-5576894	7	1	10285	26	KCNIP4
1.757e-02	-4.04	NrCAM interactions	REACTOME pathways	R-HSA-447038	7	1	10285	26	DLG3
1.782e-02	-4.03	G protein-coupled receptor dimeric complex	cellular component	GO:0038037	7	1	19108	49	GABBR2
1.782e-02	-4.03	actin-mediated cell contraction	biological process	GO:0070252	76	2	18204	49	CACNA1C,RYR2
1.808e-02	-4.01	ADENYLATE_KINASE	prosite domains	PS00113	6	1	12186	37	AK5
1.827e-02	-4.00	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	2	18204	49	GRIN2A,NRXN1
1.829e-02	-4.00	cellular process	biological process	GO:0009987	14996	46	18204	49	SLC24A4,RYR2,GABRA1,GABRA6,LRRC7,IL1RAPL2,RIMS2,GABRD,MYT1L,TRPM3,KCNMA1,ZFPM2,ST8SIA5,DLG3,KCNT1,GRID2,PTPRG,NRXN3,GABRB2,UNC13C,AK5,RBFOX3,RIMS4,KSR2,INSYN1,KCNIP4,PPP2R5B,SMPD3,CR2,OPRL1,RBFOX1,PCLO,GALNT9,RGS7,CELF5,ASTN1,CELF4,GRIN2A,OLFM1,CELF6,CPLX1,HCN1,CACNA1C,GABBR2,STXBP5L,NRXN1
1.832e-02	-4.00	-	gene3d domains	3.30.60.20	64	2	14470	47	UNC13C,KSR2
1.858e-02	-3.99	SLC27A3 (solute carrier family 27 member 3)	protein interactions	11000	83	2	19454	49	GRIN2A,MARCHF4
1.858e-02	-3.99	RBPMS2 (RNA binding protein, mRNA processing factor 2)	protein interactions	348093	83	2	19454	49	RBFOX1,CELF4
1.859e-02	-3.98	TGM1 (transglutaminase 1)	protein interactions	7051	223	3	19454	49	RBFOX1,GALNT9,HCN1
1.869e-02	-3.98	AV node cell to bundle of His cell signaling	biological process	GO:0086027	7	1	18204	49	CACNA1C
1.869e-02	-3.98	sleep	biological process	GO:0030431	7	1	18204	49	GRIN2A
1.869e-02	-3.98	observational learning	biological process	GO:0098597	7	1	18204	49	NRXN1
1.869e-02	-3.98	regulation of eating behavior	biological process	GO:1903998	7	1	18204	49	SLC24A4
1.869e-02	-3.98	cerebellar granular layer formation	biological process	GO:0021684	7	1	18204	49	GRID2
1.869e-02	-3.98	modulation of inhibitory postsynaptic potential	biological process	GO:0098828	7	1	18204	49	RIMS2
1.869e-02	-3.98	spontaneous neurotransmitter secretion	biological process	GO:0061669	7	1	18204	49	RIMS2
1.869e-02	-3.98	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	49	SMPD3
1.869e-02	-3.98	regulation of female gonad development	biological process	GO:2000194	7	1	18204	49	ZFPM2
1.869e-02	-3.98	regulation of ATPase-coupled calcium transmembrane transporter activity	biological process	GO:1901894	7	1	18204	49	RYR2
1.869e-02	-3.98	urinary bladder smooth muscle contraction	biological process	GO:0014832	7	1	18204	49	KCNMA1
1.869e-02	-3.98	positive regulation of long-term synaptic depression	biological process	GO:1900454	7	1	18204	49	GRID2
1.869e-02	-3.98	olfactory nerve development	biological process	GO:0021553	7	1	18204	49	SLC24A4
1.869e-02	-3.98	dense core granule exocytosis	biological process	GO:1990504	7	1	18204	49	UNC13C
1.869e-02	-3.98	AV node cell action potential	biological process	GO:0086016	7	1	18204	49	CACNA1C
1.869e-02	-3.98	cerebellar granule cell differentiation	biological process	GO:0021707	7	1	18204	49	GRID2
1.872e-02	-3.98	regulation of cardiac muscle contraction	biological process	GO:0055117	78	2	18204	49	CACNA1C,RYR2
1.873e-02	-3.98	response to nitrogen compound	biological process	GO:1901698	1021	7	18204	49	GABRB2,HCN1,GRIN2A,RYR2,SLC24A4,SMPD3,RGS7
1.875e-02	-3.98	GPHH_dom	interpro domains	IPR031649	7	1	18521	50	CACNA1C
1.875e-02	-3.98	Znf_C2H2C	interpro domains	IPR002515	7	1	18521	50	MYT1L
1.875e-02	-3.98	VDCC_a1su_IQ	interpro domains	IPR014873	7	1	18521	50	CACNA1C
1.875e-02	-3.98	Munc13_1	interpro domains	IPR014770	7	1	18521	50	UNC13C
1.875e-02	-3.98	MUN_dom	interpro domains	IPR010439	7	1	18521	50	UNC13C
1.881e-02	-3.97	interleukin-1 receptor activity	molecular function	GO:0004908	7	1	18094	49	IL1RAPL2
1.881e-02	-3.97	NMDA glutamate receptor activity	molecular function	GO:0004972	7	1	18094	49	GRIN2A
1.881e-02	-3.97	sphingomyelin phosphodiesterase activity	molecular function	GO:0004767	7	1	18094	49	SMPD3
1.881e-02	-3.97	G protein-coupled opioid receptor activity	molecular function	GO:0004985	7	1	18094	49	OPRL1
1.890e-02	-3.97	protein-RNA complex organization	biological process	GO:0071826	210	3	18204	49	CELF6,CELF5,CELF4
1.894e-02	-3.97	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	6	16828	48	RYR2,PCLO,GRID2,RIMS2,ASTN1,LRRC7
1.900e-02	-3.96	SMPD2 (sphingomyelin phosphodiesterase 2)	protein interactions	6610	84	2	19454	49	MARCHF4,GRIN2A
1.910e-02	-3.96	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	9	16828	48	MYT1L,NRXN1,GABBR2,RGS7,RIMS2,R3HDM1,RYR2,PCLO,CELF5
1.910e-02	-3.96	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	9	16828	48	RYR2,R3HDM1,PCLO,CELF5,RGS7,RIMS2,GABBR2,MYT1L,NRXN1
1.912e-02	-3.96	Ca_chan_IQ	pfam domains	PF08763	7	1	17795	49	CACNA1C
1.912e-02	-3.96	MUN	pfam domains	PF06292	7	1	17795	49	UNC13C
1.912e-02	-3.96	GPHH	pfam domains	PF16905	7	1	17795	49	CACNA1C
1.926e-02	-3.95	ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3)	protein interactions	489	226	3	19454	49	GRIN2A,MARCHF4,GABRA6
1.933e-02	-3.95	-	gene3d domains	4.10.320.30	6	1	14470	47	MYT1L
1.933e-02	-3.95	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	47	RYR2
1.949e-02	-3.94	pleura-mesothelioma-epithelial	COSMIC cancer mutations	pleura-mesothelioma-epithelial	362	4	16828	48	CELF4,RYR2,PCLO,RGS7
1.984e-02	-3.92	epithelial	COSMIC cancer mutations	epithelial	364	4	16828	48	RYR2,PCLO,CELF4,RGS7
1.985e-02	-3.92	superpathway of adenosine nucleotides de novo biosynthesis I	BIOCYC pathways	META_PWY-7229	6	1	902	3	AK5
1.986e-02	-3.92	RBFOX1 (RNA binding fox-1 homolog 1)	protein interactions	54715	86	2	19454	49	RBFOX1,RBFOX3
1.998e-02	-3.91	PEX5L (peroxisomal biogenesis factor 5 like)	protein interactions	51555	8	1	19454	49	HCN1
1.998e-02	-3.91	TAFA1 (TAFA chemokine like family member 1)	protein interactions	407738	8	1	19454	49	NRXN3
1.998e-02	-3.91	DHRS11 (dehydrogenase/reductase 11)	protein interactions	79154	8	1	19454	49	DLG3
1.998e-02	-3.91	OR5H1 (olfactory receptor family 5 subfamily H member 1)	protein interactions	26341	8	1	19454	49	RBFOX3
1.998e-02	-3.91	TMEM135 (transmembrane protein 135)	protein interactions	65084	8	1	19454	49	SMPD3
1.998e-02	-3.91	DEFB104A (defensin beta 104A)	protein interactions	140596	8	1	19454	49	PTPRG
1.998e-02	-3.91	C18orf32 (chromosome 18 open reading frame 32)	protein interactions	497661	8	1	19454	49	CACNA1C
2.010e-02	-3.91	Hurthle_cell_carcinoma	COSMIC cancer mutations	Hurthle_cell_carcinoma	203	3	16828	48	ZFPM2,GABRD,ASTN1
2.010e-02	-3.91	thyroid-carcinoma-Hurthle_cell_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-Hurthle_cell_carcinoma	203	3	16828	48	ZFPM2,GABRD,ASTN1
2.034e-02	-3.90	cone photoreceptor outer segment	cellular component	GO:0120199	8	1	19108	49	SLC24A4
2.035e-02	-3.89	posterior_fossa	COSMIC cancer mutations	posterior_fossa	77	2	16828	48	LRRC7,STXBP5L
2.036e-02	-3.89	C1	smart domains	SM00109	65	2	9717	33	UNC13C,KSR2
2.056e-02	-3.88	muscle organ morphogenesis	biological process	GO:0048644	82	2	18204	49	ZFPM2,RYR2
2.059e-02	-3.88	regulation of cell junction assembly	biological process	GO:1901888	217	3	18204	49	NRXN1,IL1RAPL2,GRID2
2.073e-02	-3.88	TAP2 (transporter 2, ATP binding cassette subfamily B member)	protein interactions	6891	88	2	19454	49	GRIN2A,MARCHF4
2.073e-02	-3.88	RNF114 (ring finger protein 114)	protein interactions	55905	88	2	19454	49	CPLX1,AK5
2.085e-02	-3.87	human chr16p13.2	chromosome location	human chr16p13.2	11	1	26134	50	GRIN2A
2.103e-02	-3.86	cardiac muscle contraction	biological process	GO:0060048	83	2	18204	49	CACNA1C,RYR2
2.107e-02	-3.86	ZF_CCHHC	prosite domains	PS51802	7	1	12186	37	MYT1L
2.107e-02	-3.86	MHD1	prosite domains	PS51258	7	1	12186	37	UNC13C
2.113e-02	-3.86	regulation of metal ion transport	biological process	GO:0010959	393	4	18204	49	KCNIP4,RGS7,RYR2,CACNA1C
2.127e-02	-3.85	ConA-like_dom_sf	interpro domains	IPR013320	219	3	18521	50	NRXN3,NRXN1,RYR2
2.130e-02	-3.85	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	5	16828	48	CACNA1C,ZNF804A,KSR2,DLG3,LRRC7
2.134e-02	-3.85	gonadal mesoderm development	biological process	GO:0007506	8	1	18204	49	ZFPM2
2.134e-02	-3.85	regulation of hyaluronan biosynthetic process	biological process	GO:1900125	8	1	18204	49	SMPD3
2.134e-02	-3.85	negative regulation of complement activation, classical pathway	biological process	GO:0045959	8	1	18204	49	CR2
2.134e-02	-3.85	negative regulation of G0 to G1 transition	biological process	GO:0070317	8	1	18204	49	PPP2R5B
2.134e-02	-3.85	positive regulation of male gonad development	biological process	GO:2000020	8	1	18204	49	ZFPM2
2.134e-02	-3.85	micturition	biological process	GO:0060073	8	1	18204	49	KCNMA1
2.134e-02	-3.85	chondrocyte development involved in endochondral bone morphogenesis	biological process	GO:0003433	8	1	18204	49	SMPD3
2.134e-02	-3.85	atrioventricular valve formation	biological process	GO:0003190	8	1	18204	49	OLFM1
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.146e-02	-3.84	immunoglobulin receptor binding	molecular function	GO:0034987	8	1	18094	49	CR2
2.151e-02	-3.84	regulation of release of sequestered calcium ion into cytosol	biological process	GO:0051279	84	2	18204	49	RYR2,CACNA1C
2.151e-02	-3.84	odontogenesis of dentin-containing tooth	biological process	GO:0042475	84	2	18204	49	SMPD3,SLC24A4
2.180e-02	-3.83	UBQLN1 (ubiquilin 1)	protein interactions	29979	424	4	19454	49	GABRA6,GABRA1,GABRB2,GABRD
2.180e-02	-3.83	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	3	19454	49	DLG3,LRRC7,GRIN2A
2.182e-02	-3.82	LSDAT_euk	pfam domains	PF18139	8	1	17795	49	TRPM3
2.193e-02	-3.82	Platelet homeostasis	REACTOME pathways	R-HSA-418346	91	2	10285	26	PPP2R5B,KCNMA1
2.244e-02	-3.80	G alpha (i) signalling events	REACTOME pathways	R-HSA-418594	242	3	10285	26	GABBR2,OPRL1,RGS7
2.245e-02	-3.80	NETO1 (neuropilin and tolloid like 1)	protein interactions	81832	9	1	19454	49	GRIN2A
2.245e-02	-3.80	KLK4 (kallikrein related peptidase 4)	protein interactions	9622	9	1	19454	49	KCNIP4
2.245e-02	-3.80	GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2)	protein interactions	2561	9	1	19454	49	GABRA1
2.245e-02	-3.80	Ubc (ubiquitin C)	protein interactions	50522	9	1	19454	49	STXBP5L
2.247e-02	-3.80	regulation of potassium ion transmembrane transport	biological process	GO:1901379	86	2	18204	49	KCNIP4,RGS7
2.252e-02	-3.79	-	gene3d domains	6.10.250.2500	7	1	14470	47	CACNA1C
2.252e-02	-3.79	-	gene3d domains	6.10.250.2180	7	1	14470	47	CACNA1C
2.253e-02	-3.79	Ca2+ activated K+ channels	REACTOME pathways	R-HSA-1296052	9	1	10285	26	KCNMA1
2.260e-02	-3.79	synovial	COSMIC cancer mutations	synovial	8	1	16828	48	RYR2
2.260e-02	-3.79	bone-knee-chondrosarcoma-synovial	COSMIC cancer mutations	bone-knee-chondrosarcoma-synovial	8	1	16828	48	RYR2
2.270e-02	-3.79	gallbladder	COSMIC cancer mutations	gallbladder	2821	14	16828	48	ZNF804A,GABRA6,KSR2,TRPM3,CR2,GRID2,ASTN1,GRIN2A,RIMS4,OLFM1,PCLO,R3HDM1,HCN1,PTPRG
2.270e-02	-3.79	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	14	16828	48	OLFM1,RIMS4,GRIN2A,HCN1,R3HDM1,PCLO,PTPRG,TRPM3,KSR2,CR2,ZNF804A,GABRA6,ASTN1,GRID2
2.272e-02	-3.78	human chr8q23.1	chromosome location	human chr8q23.1	12	1	26134	50	ZFPM2
2.283e-02	-3.78	regulation of secretion	biological process	GO:0051046	605	5	18204	49	RIMS2,PCLO,RIMS4,SMPD3,CPLX1
2.285e-02	-3.78	NMDA selective glutamate receptor complex	cellular component	GO:0017146	9	1	19108	49	GRIN2A
2.285e-02	-3.78	junctional sarcoplasmic reticulum membrane	cellular component	GO:0014701	9	1	19108	49	RYR2
2.296e-02	-3.77	associative learning	biological process	GO:0008306	87	2	18204	49	GRIN2A,OPRL1
2.313e-02	-3.77	sphingomyelin metabolism/ceramide salvage	BIOCYC pathways	HUMAN_PWY3DJ-11281	7	1	902	3	SMPD3
2.313e-02	-3.77	purine deoxyribonucleosides salvage	BIOCYC pathways	META_PWY-7224	7	1	902	3	AK5
2.318e-02	-3.76	RAF/MAP kinase cascade	REACTOME pathways	R-HSA-5673001	245	3	10285	26	PPP2R5B,GRIN2A,KSR2
2.318e-02	-3.76	GRB2 events in EGFR signaling	REACTOME pathways	R-HSA-179812	245	3	10285	26	PPP2R5B,GRIN2A,KSR2
2.318e-02	-3.76	SOS-mediated signalling	REACTOME pathways	R-HSA-112412	245	3	10285	26	GRIN2A,PPP2R5B,KSR2
2.318e-02	-3.76	SHC1 events in EGFR signaling	REACTOME pathways	R-HSA-180336	245	3	10285	26	KSR2,GRIN2A,PPP2R5B
2.321e-02	-3.76	Synaptic vesicle cycle	KEGG pathways	ko04721	63	2	7161	27	CPLX1,UNC13C
2.321e-02	-3.76	Synaptic vesicle cycle	KEGG pathways	hsa04721	63	2	7161	27	UNC13C,CPLX1
2.327e-02	-3.76	mRNA metabolic process	biological process	GO:0016071	608	5	18204	49	CELF4,RBFOX3,CELF6,RBFOX1,CELF5
2.345e-02	-3.75	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	49	DLG3,GRIN2A
2.354e-02	-3.75	Ca_chan_IQ	smart domains	SM01062	7	1	9717	33	CACNA1C
2.387e-02	-3.74	parotid	COSMIC cancer mutations	parotid	578	5	16828	48	CACNA1C,ZNF804A,KSR2,DLG3,LRRC7
2.393e-02	-3.73	Arrhythmogenic Right Ventricular Cardiomyopathy	WikiPathways	WP2118	76	2	5310	17	CACNA1C,RYR2
2.397e-02	-3.73	regulation of complement activation, classical pathway	biological process	GO:0030450	9	1	18204	49	CR2
2.397e-02	-3.73	spontaneous synaptic transmission	biological process	GO:0098814	9	1	18204	49	RIMS2
2.397e-02	-3.73	urinary tract smooth muscle contraction	biological process	GO:0014848	9	1	18204	49	KCNMA1
2.397e-02	-3.73	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	49	NRXN1
2.397e-02	-3.73	synaptic vesicle docking	biological process	GO:0016081	9	1	18204	49	UNC13C
2.397e-02	-3.73	negative regulation of cAMP-mediated signaling	biological process	GO:0043951	9	1	18204	49	OPRL1
2.397e-02	-3.73	regulation of male gonad development	biological process	GO:2000018	9	1	18204	49	ZFPM2
2.397e-02	-3.73	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	49	RYR2
2.397e-02	-3.73	G protein-coupled opioid receptor signaling pathway	biological process	GO:0038003	9	1	18204	49	OPRL1
2.397e-02	-3.73	positive regulation of gonad development	biological process	GO:1905941	9	1	18204	49	ZFPM2
2.397e-02	-3.73	cerebellar granular layer morphogenesis	biological process	GO:0021683	9	1	18204	49	GRID2
2.403e-02	-3.73	EGF	smart domains	SM00181	184	3	9717	33	NRXN1,ASTN1,NRXN3
2.404e-02	-3.73	VDCCAlpha1	interpro domains	IPR002077	9	1	18521	50	CACNA1C
2.404e-02	-3.73	Adenylat/UMP-CMP_kin	interpro domains	IPR000850	9	1	18521	50	AK5
2.404e-02	-3.73	Quino_amine_DH_bsu	interpro domains	IPR011044	9	1	18521	50	OLFM1
2.404e-02	-3.73	NaCa_Exmemb	interpro domains	IPR004837	9	1	18521	50	SLC24A4
2.404e-02	-3.73	NCX_ion-bd_dom_sf	interpro domains	IPR044880	9	1	18521	50	SLC24A4
2.412e-02	-3.72	intracellularly cAMP-activated cation channel activity	molecular function	GO:0005222	9	1	18094	49	HCN1
2.412e-02	-3.72	adenylate kinase activity	molecular function	GO:0004017	9	1	18094	49	AK5
2.417e-02	-3.72	Signalling to p38 via RIT and RIN	REACTOME pathways	R-HSA-187706	249	3	10285	26	KSR2,PPP2R5B,GRIN2A
2.417e-02	-3.72	ARMS-mediated activation	REACTOME pathways	R-HSA-170984	249	3	10285	26	PPP2R5B,GRIN2A,KSR2
2.430e-02	-3.72	human chr9q34.3	chromosome location	human chr9q34.3	126	2	26134	50	OLFM1,KCNT1
2.438e-02	-3.71	HOMER1 (homer scaffold protein 1)	protein interactions	9456	96	2	19454	49	RYR2,INSYN1
2.443e-02	-3.71	Frs2-mediated activation	REACTOME pathways	R-HSA-170968	250	3	10285	26	GRIN2A,PPP2R5B,KSR2
2.446e-02	-3.71	feeding behavior	biological process	GO:0007631	90	2	18204	49	OPRL1,SLC24A4
2.450e-02	-3.71	cellular component biogenesis	biological process	GO:0044085	2716	13	18204	49	GRID2,GABRA6,SMPD3,CELF6,UNC13C,HCN1,GABRB2,NRXN1,TRPM3,PCLO,CELF5,GABRA1,CELF4
2.452e-02	-3.71	Na_Ca_ex	pfam domains	PF01699	9	1	17795	49	SLC24A4
2.461e-02	-3.70	Renin secretion	KEGG pathways	hsa04924	65	2	7161	27	CACNA1C,KCNMA1
2.461e-02	-3.70	Renin secretion	KEGG pathways	ko04924	65	2	7161	27	CACNA1C,KCNMA1
2.468e-02	-3.70	MAPK1/MAPK3 signaling	REACTOME pathways	R-HSA-5684996	251	3	10285	26	KSR2,PPP2R5B,GRIN2A
2.470e-02	-3.70	EGF-like_dom	interpro domains	IPR000742	232	3	18521	50	NRXN1,NRXN3,ASTN1
2.486e-02	-3.69	SNTA1 (syntrophin alpha 1)	protein interactions	6640	97	2	19454	49	INSYN1,RYR2
2.486e-02	-3.69	ATP13A2 (ATPase cation transporting 13A2)	protein interactions	23400	97	2	19454	49	MARCHF4,NRXN1
2.491e-02	-3.69	GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)	protein interactions	116443	10	1	19454	49	GRIN2A
2.491e-02	-3.69	ANKRD26P1 (ankyrin repeat domain 26 pseudogene 1)	protein interactions	124149	10	1	19454	49	RBFOX3
2.491e-02	-3.69	FCER2 (Fc epsilon receptor II)	protein interactions	2208	10	1	19454	49	CR2
2.493e-02	-3.69	neurogenesis	biological process	GO:0022008	1334	8	18204	49	NRXN3,GRID2,MYT1L,ASTN1,HCN1,GABRB2,GRIN2A,NRXN1
2.494e-02	-3.69	Prolonged ERK activation events	REACTOME pathways	R-HSA-169893	252	3	10285	26	KSR2,GRIN2A,PPP2R5B
2.518e-02	-3.68	oesophagus	COSMIC cancer mutations	oesophagus	14970	47	16828	48	RBFOX1,STXBP5L,KCNIP4,GABBR2,CELF6,NRXN3,DLG3,AK5,GABRD,OLFM1,MYT1L,CPLX1,RIMS4,GABRB2,ST8SIA5,RIMS2,R3HDM1,TRPM3,GALNT9,LRRC7,CELF4,ZFPM2,UNC13C,GRIN2A,GABRA1,IL1RAPL2,CELF5,KSR2,CR2,ZNF804A,SLC24A4,OPRL1,RYR2,GRID2,CACNA1C,RGS7,RBFOX3,SMPD3,GABRA6,ASTN1,KCNT1,NRXN1,PPP2R5B,KCNMA1,HCN1,PCLO,PTPRG
2.518e-02	-3.68	ADENYLTKNASE	prints domains	PR00094	7	1	5227	19	AK5
2.519e-02	-3.68	Signaling by Leptin	REACTOME pathways	R-HSA-2586552	253	3	10285	26	GRIN2A,PPP2R5B,KSR2
2.531e-02	-3.68	uveal_tract	COSMIC cancer mutations	uveal_tract	587	5	16828	48	PTPRG,PCLO,KCNMA1,MYT1L,TRPM3
2.534e-02	-3.68	PTK2B (protein tyrosine kinase 2 beta)	protein interactions	2185	98	2	19454	49	GRIN2A,DLG3
2.548e-02	-3.67	protein tetramerization	biological process	GO:0051262	92	2	18204	49	TRPM3,HCN1
2.570e-02	-3.66	Guanylate Kinase phosphate binding domain	gene3d domains	3.30.63.10	8	1	14470	47	DLG3
2.571e-02	-3.66	Interleukin receptor SHC signaling	REACTOME pathways	R-HSA-912526	255	3	10285	26	PPP2R5B,GRIN2A,KSR2
2.578e-02	-3.66	blood circulation	biological process	GO:0008015	418	4	18204	49	KCNMA1,CACNA1C,RYR2,OPRL1
2.597e-02	-3.65	Signalling to RAS	REACTOME pathways	R-HSA-167044	256	3	10285	26	KSR2,GRIN2A,PPP2R5B
2.604e-02	-3.65	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	27	GRIN2A,CACNA1C
2.604e-02	-3.65	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	27	GRIN2A,CACNA1C
2.607e-02	-3.65	Nitric Oxide Signaling Pathway	SMPDB pathways	SMP0063777	9	1	1369	4	GRIN2A
2.616e-02	-3.64	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	49	KCNIP4,LRRC7,GRIN2A
2.616e-02	-3.64	muscle contraction	biological process	GO:0006936	238	3	18204	49	RYR2,KCNMA1,CACNA1C
2.616e-02	-3.64	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	biological process	GO:0007188	238	3	18204	49	RIMS2,OPRL1,GABBR2
2.646e-02	-3.63	human chr3p14.2	chromosome location	human chr3p14.2	14	1	26134	50	PTPRG
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.650e-02	-3.63	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	3	10285	26	KSR2,GRIN2A,PPP2R5B
2.660e-02	-3.63	neurotransmitter receptor transport, endosome to postsynaptic membrane	biological process	GO:0098887	10	1	18204	49	LRRC7
2.660e-02	-3.63	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	49	NRXN1
2.660e-02	-3.63	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	49	RYR2
2.660e-02	-3.63	ribonucleoside diphosphate biosynthetic process	biological process	GO:0009188	10	1	18204	49	AK5
2.660e-02	-3.63	neurotransmitter receptor transport, endosome to plasma membrane	biological process	GO:0099639	10	1	18204	49	LRRC7
2.660e-02	-3.63	response to histamine	biological process	GO:0034776	10	1	18204	49	GABRB2
2.660e-02	-3.63	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	49	NRXN1
2.660e-02	-3.63	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	1	18204	49	NRXN1
2.660e-02	-3.63	inhibitory postsynaptic potential	biological process	GO:0060080	10	1	18204	49	INSYN1
2.660e-02	-3.63	serotonin metabolic process	biological process	GO:0042428	10	1	18204	49	GRIN2A
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR2
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR2
2.668e-02	-3.62	FYVE_2	interpro domains	IPR041282	10	1	18521	50	RIMS2
2.668e-02	-3.62	TPR_2	interpro domains	IPR013105	10	1	18521	50	TTC9B
2.676e-02	-3.62	profilin binding	molecular function	GO:0005522	10	1	18094	49	PCLO
2.676e-02	-3.62	mitogen-activated protein kinase kinase binding	molecular function	GO:0031434	10	1	18094	49	KSR2
2.676e-02	-3.62	NAD+ nucleosidase activity	molecular function	GO:0003953	10	1	18094	49	IL1RAPL2
2.676e-02	-3.62	calcium:sodium antiporter activity	molecular function	GO:0005432	10	1	18094	49	SLC24A4
2.677e-02	-3.62	Amphetamine addiction	KEGG pathways	ko05031	68	2	7161	27	CACNA1C,GRIN2A
2.677e-02	-3.62	Amphetamine addiction	KEGG pathways	hsa05031	68	2	7161	27	GRIN2A,CACNA1C
2.679e-02	-3.62	LRP5 (LDL receptor related protein 5)	protein interactions	4041	101	2	19454	49	ST8SIA5,MARCHF4
2.715e-02	-3.61	-	gene3d domains	2.80.10.50	79	2	14470	47	GALNT9,RYR2
2.719e-02	-3.60	EGF-type_Asp/Asn_hydroxyl_site	interpro domains	IPR000152	95	2	18521	50	NRXN1,NRXN3
2.720e-02	-3.60	ADK	pfam domains	PF00406	10	1	17795	49	AK5
2.720e-02	-3.60	R3H	pfam domains	PF01424	10	1	17795	49	R3HDM1
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	RYR2
2.720e-02	-3.60	TPR_2	pfam domains	PF07719	10	1	17795	49	TTC9B
2.720e-02	-3.60	FYVE_2	pfam domains	PF02318	10	1	17795	49	RIMS2
2.728e-02	-3.60	CTSV (cathepsin V)	protein interactions	1515	102	2	19454	49	GALNT9,RBFOX1
2.737e-02	-3.60	PIP5K1P1 (phosphatidylinositol-4-phosphate 5-kinase type 1 pseudogene 1)	protein interactions	206426	11	1	19454	49	NRXN3
2.737e-02	-3.60	CACNA1D (calcium voltage-gated channel subunit alpha1 D)	protein interactions	776	11	1	19454	49	RYR2
2.737e-02	-3.60	KCTD16 (potassium channel tetramerization domain containing 16)	protein interactions	57528	11	1	19454	49	GABBR2
2.737e-02	-3.60	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	49	NRXN1
2.737e-02	-3.60	DUS4L (dihydrouridine synthase 4 like)	protein interactions	11062	11	1	19454	49	PTPRG
2.737e-02	-3.60	IL17A (interleukin 17A)	protein interactions	3605	11	1	19454	49	KCNIP4
2.737e-02	-3.60	RIMS3 (regulating synaptic membrane exocytosis 3)	protein interactions	9783	11	1	19454	49	RIMS2
2.758e-02	-3.59	Interleukin-2 signaling	REACTOME pathways	R-HSA-451927	262	3	10285	26	KSR2,GRIN2A,PPP2R5B
2.767e-02	-3.59	signal transduction	biological process	GO:0007165	4637	19	18204	49	SLC24A4,PCLO,RGS7,KSR2,RYR2,CELF4,GRIN2A,INSYN1,SMPD3,PPP2R5B,OLFM1,GRID2,PTPRG,CR2,OPRL1,CACNA1C,GABBR2,IL1RAPL2,RIMS2
2.785e-02	-3.58	Signalling to ERKs	REACTOME pathways	R-HSA-187687	263	3	10285	26	KSR2,PPP2R5B,GRIN2A
2.786e-02	-3.58	G protein-coupled receptor complex	cellular component	GO:0097648	11	1	19108	49	GABBR2
2.810e-02	-3.57	nerve development	biological process	GO:0021675	97	2	18204	49	SLC24A4,GABRB2
2.811e-02	-3.57	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	26	RYR2,TRPM3
2.828e-02	-3.57	SPP1 (secreted phosphoprotein 1)	protein interactions	6696	104	2	19454	49	RIMS4,ZNF804A
2.828e-02	-3.57	MSI1 (musashi RNA binding protein 1)	protein interactions	4440	104	2	19454	49	CELF5,RBFOX3
2.840e-02	-3.56	FCERI mediated MAPK activation	REACTOME pathways	R-HSA-2871796	265	3	10285	26	GRIN2A,PPP2R5B,KSR2
2.872e-02	-3.55	mRNA binding	molecular function	GO:0003729	639	5	18094	49	CELF5,RBFOX1,RBFOX3,CELF6,CELF4
2.886e-02	-3.55	NCX, central ion-binding region	gene3d domains	1.20.1420.30	9	1	14470	47	SLC24A4
2.886e-02	-3.55	-	gene3d domains	1.10.357.50	9	1	14470	47	UNC13C
2.886e-02	-3.55	R3H-like domain	gene3d domains	3.30.1370.50	9	1	14470	47	R3HDM1
2.893e-02	-3.54	Methadone Metabolism Pathway	SMPDB pathways	SMP0000624	10	1	1369	4	GRIN2A
2.917e-02	-3.53	regulation of striated muscle contraction	biological process	GO:0006942	99	2	18204	49	CACNA1C,RYR2
2.917e-02	-3.53	heart contraction	biological process	GO:0060047	99	2	18204	49	RYR2,CACNA1C
2.922e-02	-3.53	negative regulation of excitatory postsynaptic potential	biological process	GO:0090394	11	1	18204	49	CELF4
2.922e-02	-3.53	cellular response to peptide	biological process	GO:1901653	11	1	18204	49	SMPD3
2.922e-02	-3.53	cellular response to caffeine	biological process	GO:0071313	11	1	18204	49	RYR2
2.922e-02	-3.53	negative regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002924	11	1	18204	49	CR2
2.922e-02	-3.53	nucleoside monophosphate phosphorylation	biological process	GO:0046940	11	1	18204	49	AK5
2.922e-02	-3.53	drinking behavior	biological process	GO:0042756	11	1	18204	49	SLC24A4
2.922e-02	-3.53	cellular response to epinephrine stimulus	biological process	GO:0071872	11	1	18204	49	RYR2
2.922e-02	-3.53	regulation of neurotrophin TRK receptor signaling pathway	biological process	GO:0051386	11	1	18204	49	PPP2R5B
2.922e-02	-3.53	retinal cone cell development	biological process	GO:0046549	11	1	18204	49	HCN1
2.922e-02	-3.53	synaptic vesicle clustering	biological process	GO:0097091	11	1	18204	49	PCLO
2.929e-02	-3.53	EF-hand_7	pfam domains	PF13499	97	2	17795	49	RYR2,KCNIP4
2.931e-02	-3.53	IL-1_rcpt_fam	interpro domains	IPR015621	11	1	18521	50	IL1RAPL2
2.931e-02	-3.53	R3H_dom_sf	interpro domains	IPR036867	11	1	18521	50	R3HDM1
2.931e-02	-3.53	R3H_dom	interpro domains	IPR001374	11	1	18521	50	R3HDM1
2.931e-02	-3.53	Solute-binding_3/MltF_N	interpro domains	IPR001638	11	1	18521	50	GRIN2A
2.940e-02	-3.53	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	49	NRXN1
2.940e-02	-3.53	cyclic nucleotide-activated monoatomic ion channel activity	molecular function	GO:0043855	11	1	18094	49	HCN1
2.940e-02	-3.53	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	molecular function	GO:0005221	11	1	18094	49	HCN1
2.940e-02	-3.53	complement receptor activity	molecular function	GO:0004875	11	1	18094	49	CR2
2.958e-02	-3.52	breast-carcinoma	COSMIC cancer mutations	breast-carcinoma	15030	47	16828	48	NRXN1,PPP2R5B,KCNMA1,PTPRG,HCN1,PCLO,SMPD3,GABRA6,ASTN1,KCNT1,CACNA1C,RGS7,RBFOX3,CR2,KSR2,OPRL1,SLC24A4,ZNF804A,RYR2,GRID2,LRRC7,ZFPM2,UNC13C,GRIN2A,CELF4,IL1RAPL2,GABRA1,CELF5,TRPM3,GALNT9,GABRD,MYT1L,OLFM1,AK5,RIMS4,RIMS2,GABRB2,ST8SIA5,R3HDM1,STXBP5L,RBFOX1,CELF6,TTC9B,KCNIP4,GABBR2,DLG3,NRXN3
2.976e-02	-3.51	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	ko05412	72	2	7161	27	RYR2,CACNA1C
2.976e-02	-3.51	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	hsa05412	72	2	7161	27	CACNA1C,RYR2
2.976e-02	-3.51	Calcium signaling pathway	KEGG pathways	ko04020	181	3	7161	27	RYR2,GRIN2A,CACNA1C
2.976e-02	-3.51	Calcium signaling pathway	KEGG pathways	hsa04020	181	3	7161	27	GRIN2A,RYR2,CACNA1C
2.979e-02	-3.51	RET signaling	REACTOME pathways	R-HSA-8853659	270	3	10285	26	KSR2,PPP2R5B,GRIN2A
2.982e-02	-3.51	ANO5 (anoctamin 5)	protein interactions	203859	12	1	19454	49	MARCHF4
2.982e-02	-3.51	SPDYC (speedy/RINGO cell cycle regulator family member C)	protein interactions	387778	12	1	19454	49	RBFOX3
2.982e-02	-3.51	CACNA1S (calcium voltage-gated channel subunit alpha1 S)	protein interactions	779	12	1	19454	49	RIMS2
2.982e-02	-3.51	SIRPB1 (signal regulatory protein beta 1)	protein interactions	10326	12	1	19454	49	RBFOX1
2.982e-02	-3.51	ISG20 (interferon stimulated exonuclease gene 20)	protein interactions	3669	12	1	19454	49	PTPRG
2.988e-02	-3.51	RINGv	pfam domains	PF12906	11	1	17795	49	MARCHF4
2.988e-02	-3.51	SBP_bac_3	pfam domains	PF00497	11	1	17795	49	GRIN2A
2.993e-02	-3.51	Ionotropic activity of Kainate Receptors	REACTOME pathways	R-HSA-451306	12	1	10285	26	DLG3
2.993e-02	-3.51	Activation of Ca-permeable Kainate Receptor	REACTOME pathways	R-HSA-451308	12	1	10285	26	DLG3
2.996e-02	-3.51	MIR	prosite domains	PS50919	10	1	12186	37	RYR2
2.997e-02	-3.51	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	biological process	GO:0000377	251	3	18204	49	CELF6,CELF5,CELF4
2.997e-02	-3.51	mRNA splicing, via spliceosome	biological process	GO:0000398	251	3	18204	49	CELF5,CELF6,CELF4
3.007e-02	-3.50	haemangiopericytic	COSMIC cancer mutations	haemangiopericytic	95	2	16828	48	GRIN2A,PCLO
3.007e-02	-3.50	meninges-meningioma-haemangiopericytic	COSMIC cancer mutations	meninges-meningioma-haemangiopericytic	95	2	16828	48	PCLO,GRIN2A
3.008e-02	-3.50	Interleukin-3, 5 and GM-CSF signaling	REACTOME pathways	R-HSA-512988	271	3	10285	26	GRIN2A,PPP2R5B,KSR2
3.016e-02	-3.50	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	24	16828	48	RYR2,GRID2,NRXN3,KCNIP4,SLC24A4,ZNF804A,R3HDM1,GABRB2,RGS7,CACNA1C,OLFM1,MYT1L,KCNT1,ASTN1,GALNT9,TRPM3,SMPD3,PCLO,PTPRG,CELF4,ZFPM2,UNC13C,GRIN2A,PPP2R5B
3.017e-02	-3.50	R3H	smart domains	SM00393	9	1	9717	33	R3HDM1
3.018e-02	-3.50	human chr2q21.3	chromosome location	human chr2q21.3	16	1	26134	50	R3HDM1
3.027e-02	-3.50	actin filament-based movement	biological process	GO:0030048	101	2	18204	49	CACNA1C,RYR2
3.027e-02	-3.50	regulation of potassium ion transport	biological process	GO:0043266	101	2	18204	49	KCNIP4,RGS7
3.035e-02	-3.49	L-type voltage-gated calcium channel complex	cellular component	GO:1990454	12	1	19108	49	CACNA1C
3.120e-02	-3.47	RNA splicing, via transesterification reactions	biological process	GO:0000375	255	3	18204	49	CELF5,CELF6,CELF4
3.124e-02	-3.47	soft_tissue-fat-liposarcoma-myxoid-round_cell	COSMIC cancer mutations	soft_tissue-fat-liposarcoma-myxoid-round_cell	97	2	16828	48	HCN1,GABRA6
3.124e-02	-3.47	myxoid-round_cell	COSMIC cancer mutations	myxoid-round_cell	97	2	16828	48	HCN1,GABRA6
3.125e-02	-3.47	regulation of biological process	biological process	GO:0050789	12079	39	18204	49	MYT1L,RGS7,PCLO,ZFPM2,KCNMA1,CELF5,GRIN2A,CELF4,DLG3,GRID2,OLFM1,CELF6,PTPRG,CACNA1C,GABBR2,UNC13C,GABRB2,HCN1,CPLX1,NRXN1,SLC24A4,RBFOX3,RIMS4,ZNF804A,GABRA1,RYR2,KSR2,KCNIP4,INSYN1,PPP2R5B,GABRA6,SMPD3,CR2,OPRL1,LRRC7,RBFOX1,RIMS2,GABRD,IL1RAPL2
3.130e-02	-3.46	Cardiac muscle contraction	KEGG pathways	hsa04260	74	2	7161	27	CACNA1C,RYR2
3.130e-02	-3.46	Cardiac muscle contraction	KEGG pathways	ko04260	74	2	7161	27	RYR2,CACNA1C
3.138e-02	-3.46	regulation of heart rate	biological process	GO:0002027	103	2	18204	49	RYR2,CACNA1C
3.155e-02	-3.46	regulation of multicellular organismal process	biological process	GO:0051239	3113	14	18204	49	NRXN1,RIMS2,CACNA1C,OPRL1,PTPRG,SMPD3,GRID2,OLFM1,CELF4,GRIN2A,KSR2,RYR2,ZFPM2,SLC24A4
3.172e-02	-3.45	anatomical structure morphogenesis	biological process	GO:0009653	2225	11	18204	49	DLG3,RYR2,NRXN1,HCN1,CACNA1C,ZFPM2,SLC24A4,NRXN3,SMPD3,OLFM1,GRID2
3.184e-02	-3.45	regulation of synaptic vesicle membrane organization	biological process	GO:1901632	12	1	18204	49	CPLX1
3.184e-02	-3.45	regulation of synaptic vesicle fusion to presynaptic active zone membrane	biological process	GO:0031630	12	1	18204	49	CPLX1
3.184e-02	-3.45	auditory behavior	biological process	GO:0031223	12	1	18204	49	NRXN1
3.184e-02	-3.45	excitatory chemical synaptic transmission	biological process	GO:0098976	12	1	18204	49	GRIN2A
3.184e-02	-3.45	AV node cell to bundle of His cell communication	biological process	GO:0086067	12	1	18204	49	CACNA1C
3.185e-02	-3.45	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	13	16828	48	ASTN1,RYR2,CR2,STXBP5L,TRPM3,ZNF804A,GABBR2,RIMS2,PCLO,MYT1L,GRIN2A,UNC13C,ZFPM2
3.185e-02	-3.45	embryonal	COSMIC cancer mutations	embryonal	2659	13	16828	48	PCLO,RIMS2,UNC13C,GRIN2A,ZFPM2,MYT1L,RYR2,ASTN1,GABBR2,ZNF804A,STXBP5L,CR2,TRPM3
3.193e-02	-3.44	K_chnl_volt-dep_EAG/ELK/ERG	interpro domains	IPR003938	12	1	18521	50	HCN1
3.193e-02	-3.44	Rab_BD	interpro domains	IPR010911	12	1	18521	50	RIMS2
3.193e-02	-3.44	MACPF	interpro domains	IPR020864	12	1	18521	50	ASTN1
3.193e-02	-3.44	V_SNARE_CC	interpro domains	IPR042855	12	1	18521	50	STXBP5L
3.194e-02	-3.44	inorganic ion import across plasma membrane	biological process	GO:0099587	104	2	18204	49	CACNA1C,SLC24A4
3.194e-02	-3.44	inorganic cation import across plasma membrane	biological process	GO:0098659	104	2	18204	49	SLC24A4,CACNA1C
3.202e-02	-3.44	Helix hairpin bin	gene3d domains	1.10.287.630	10	1	14470	47	HCN1
3.203e-02	-3.44	MAP-kinase scaffold activity	molecular function	GO:0005078	12	1	18094	49	KSR2
3.226e-02	-3.43	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	49	NRXN1
3.226e-02	-3.43	IGLC6 (immunoglobulin lambda constant 6)	protein interactions	3542	13	1	19454	49	HCN1
3.226e-02	-3.43	PCAT1 (prostate cancer associated transcript 1)	protein interactions	100750225	13	1	19454	49	PCLO
3.226e-02	-3.43	CABP1 (calcium binding protein 1)	protein interactions	9478	13	1	19454	49	CACNA1C
3.226e-02	-3.43	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	49	RIMS2
3.226e-02	-3.43	ULBP1 (UL16 binding protein 1)	protein interactions	80329	13	1	19454	49	MARCHF4
3.226e-02	-3.43	ACBD7 (acyl-CoA binding domain containing 7)	protein interactions	414149	13	1	19454	49	PTPRG
3.227e-02	-3.43	CACHANNEL	prints domains	PR00167	9	1	5227	19	CACNA1C
3.239e-02	-3.43	Sodium/Calcium exchangers	REACTOME pathways	R-HSA-425561	13	1	10285	26	SLC24A4
3.241e-02	-3.43	PDE3B (phosphodiesterase 3B)	protein interactions	5140	112	2	19454	49	GRIN2A,MARCHF4
3.241e-02	-3.43	VPS50 (VPS50 subunit of EARP/GARPII complex)	protein interactions	55610	112	2	19454	49	INSYN1,R3HDM1
3.251e-02	-3.43	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	49	GRID2,ZNF804A
3.251e-02	-3.43	biomineral tissue development	biological process	GO:0031214	105	2	18204	49	SLC24A4,SMPD3
3.275e-02	-3.42	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	49	LRRC7,PTPRG,GRID2,PPP2R5B,ZNF804A
3.291e-02	-3.41	ZF_RING_CH	prosite domains	PS51292	11	1	12186	37	MARCHF4
3.291e-02	-3.41	G_PROTEIN_RECEP_F3_3	prosite domains	PS00981	11	1	12186	37	GABBR2
3.291e-02	-3.41	R3H	prosite domains	PS51061	11	1	12186	37	R3HDM1
3.298e-02	-3.41	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	42	16828	48	CR2,STXBP5L,KSR2,OPRL1,CELF6,ZNF804A,GABBR2,DLG3,NRXN3,GRID2,RYR2,OLFM1,MYT1L,GABRD,AK5,RIMS4,CACNA1C,CPLX1,RGS7,RBFOX3,RIMS2,ST8SIA5,GABRB2,R3HDM1,SMPD3,TRPM3,GABRA6,GALNT9,ASTN1,KCNT1,LRRC7,PPP2R5B,UNC13C,GRIN2A,ZFPM2,CELF4,IL1RAPL2,GABRA1,PTPRG,PCLO,CELF5,HCN1
3.346e-02	-3.40	MIR	smart domains	SM00472	10	1	9717	33	RYR2
3.349e-02	-3.40	axon terminus	cellular component	GO:0043679	112	2	19108	49	UNC13C,CPLX1
3.349e-02	-3.40	endometrium-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-endometrioid_carcinoma	15680	48	16828	48	NRXN1,PPP2R5B,KCNMA1,PTPRG,HCN1,PCLO,SMPD3,GABRA6,ASTN1,KCNT1,CACNA1C,RGS7,RBFOX3,CR2,KSR2,OPRL1,ZNF804A,SLC24A4,GRID2,RYR2,LRRC7,ZFPM2,GRIN2A,UNC13C,CELF4,GABRA1,IL1RAPL2,CELF5,TRPM3,GALNT9,OLFM1,GABRD,MYT1L,AK5,RIMS4,CPLX1,RIMS2,GABRB2,ST8SIA5,R3HDM1,STXBP5L,RBFOX1,TTC9B,CELF6,GABBR2,KCNIP4,DLG3,NRXN3
3.364e-02	-3.39	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	3	16828	48	IL1RAPL2,GABBR2,GRIN2A
3.364e-02	-3.39	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	3	16828	48	IL1RAPL2,GABBR2,GRIN2A
3.371e-02	-3.39	blastoma	COSMIC cancer mutations	blastoma	12	1	16828	48	GRIN2A
3.374e-02	-3.39	heart morphogenesis	biological process	GO:0003007	263	3	18204	49	RYR2,ZFPM2,OLFM1
3.374e-02	-3.39	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	5	16828	48	LRRC7,ASTN1,GRIN2A,GABBR2,GRID2
3.389e-02	-3.38	human chr7q21.11	chromosome location	human chr7q21.11	18	1	26134	50	PCLO
3.398e-02	-3.38	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	3	16828	48	RIMS2,PCLO,KCNIP4
3.429e-02	-3.37	generation of neurons	biological process	GO:0048699	1158	7	18204	49	ASTN1,HCN1,GABRB2,NRXN1,NRXN3,GRID2,MYT1L
3.444e-02	-3.37	cerebellar granular layer development	biological process	GO:0021681	13	1	18204	49	GRID2
3.444e-02	-3.37	activation of cysteine-type endopeptidase activity	biological process	GO:0097202	13	1	18204	49	GRIN2A
3.444e-02	-3.37	detection of calcium ion	biological process	GO:0005513	13	1	18204	49	RYR2
3.444e-02	-3.37	regulation of gonad development	biological process	GO:1905939	13	1	18204	49	ZFPM2
3.444e-02	-3.37	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	49	ZNF804A
3.444e-02	-3.37	response to peptide	biological process	GO:1901652	13	1	18204	49	SMPD3
3.444e-02	-3.37	negative regulation of complement activation	biological process	GO:0045916	13	1	18204	49	CR2
3.444e-02	-3.37	positive regulation of urine volume	biological process	GO:0035810	13	1	18204	49	OPRL1
3.444e-02	-3.37	prepulse inhibition	biological process	GO:0060134	13	1	18204	49	GRID2
3.444e-02	-3.37	retinal cone cell differentiation	biological process	GO:0042670	13	1	18204	49	HCN1
3.444e-02	-3.37	regulation of postsynaptic density assembly	biological process	GO:0099151	13	1	18204	49	GRID2
3.444e-02	-3.37	nucleoside diphosphate biosynthetic process	biological process	GO:0009133	13	1	18204	49	AK5
3.444e-02	-3.37	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	49	NRXN1
3.453e-02	-3.37	endometrioid_carcinoma	COSMIC cancer mutations	endometrioid_carcinoma	15690	48	16828	48	GABBR2,KCNIP4,TTC9B,CELF6,RBFOX1,STXBP5L,NRXN3,DLG3,CPLX1,RIMS4,AK5,OLFM1,GABRD,MYT1L,R3HDM1,GABRB2,ST8SIA5,RIMS2,TRPM3,GALNT9,CELF4,ZFPM2,UNC13C,GRIN2A,LRRC7,CELF5,GABRA1,IL1RAPL2,SLC24A4,ZNF804A,OPRL1,KSR2,CR2,RYR2,GRID2,CACNA1C,RBFOX3,RGS7,GABRA6,SMPD3,KCNT1,ASTN1,NRXN1,PPP2R5B,HCN1,PCLO,PTPRG,KCNMA1
3.454e-02	-3.37	Olfac-like_dom	interpro domains	IPR003112	13	1	18521	50	OLFM1
3.465e-02	-3.36	calcium:monoatomic cation antiporter activity	molecular function	GO:0015368	13	1	18094	49	SLC24A4
3.465e-02	-3.36	diacylglycerol binding	molecular function	GO:0019992	13	1	18094	49	UNC13C
3.465e-02	-3.36	myosin II binding	molecular function	GO:0045159	13	1	18094	49	STXBP5L
3.465e-02	-3.36	calcium-activated potassium channel activity	molecular function	GO:0015269	13	1	18094	49	KCNMA1
3.470e-02	-3.36	SYT5 (synaptotagmin 5)	protein interactions	6861	14	1	19454	49	NRXN1
3.470e-02	-3.36	KCNIP2 (potassium voltage-gated channel interacting protein 2)	protein interactions	30819	14	1	19454	49	KCNIP4
3.470e-02	-3.36	GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2)	protein interactions	2977	14	1	19454	49	DLG3
3.470e-02	-3.36	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	49	GRIN2A
3.470e-02	-3.36	SLC38A6 (solute carrier family 38 member 6)	protein interactions	145389	14	1	19454	49	RBFOX3
3.470e-02	-3.36	CSF3 (colony stimulating factor 3)	protein interactions	1440	14	1	19454	49	PTPRG
3.474e-02	-3.36	endometrium	COSMIC cancer mutations	endometrium	15692	48	16828	48	STXBP5L,RBFOX1,TTC9B,CELF6,KCNIP4,GABBR2,DLG3,NRXN3,MYT1L,GABRD,OLFM1,AK5,RIMS4,CPLX1,RIMS2,ST8SIA5,GABRB2,R3HDM1,TRPM3,GALNT9,LRRC7,UNC13C,GRIN2A,ZFPM2,CELF4,IL1RAPL2,GABRA1,CELF5,CR2,KSR2,OPRL1,SLC24A4,ZNF804A,GRID2,RYR2,CACNA1C,RGS7,RBFOX3,SMPD3,GABRA6,ASTN1,KCNT1,PPP2R5B,NRXN1,KCNMA1,PTPRG,PCLO,HCN1
3.484e-02	-3.36	AXIN mutants destabilize the destruction complex, activating WNT signaling	REACTOME pathways	R-HSA-4839735	14	1	10285	26	PPP2R5B
3.484e-02	-3.36	AMER1 mutants destabilize the destruction complex	REACTOME pathways	R-HSA-4839748	14	1	10285	26	PPP2R5B
3.484e-02	-3.36	AXIN missense mutants destabilize the destruction complex	REACTOME pathways	R-HSA-5467340	14	1	10285	26	PPP2R5B
3.484e-02	-3.36	Truncations of AMER1 destabilize the destruction complex	REACTOME pathways	R-HSA-5467348	14	1	10285	26	PPP2R5B
3.484e-02	-3.36	truncated APC mutants destabilize the destruction complex	REACTOME pathways	R-HSA-4839744	14	1	10285	26	PPP2R5B
3.484e-02	-3.36	APC truncation mutants have impaired AXIN binding	REACTOME pathways	R-HSA-5467337	14	1	10285	26	PPP2R5B
3.496e-02	-3.35	ATXN2 (ataxin 2)	protein interactions	6311	285	3	19454	49	CELF5,RBFOX1,R3HDM1
3.510e-02	-3.35	DUSP23 (dual specificity phosphatase 23)	protein interactions	54935	117	2	19454	49	PTPRG,ZFPM2
3.522e-02	-3.35	OLF	pfam domains	PF02191	13	1	17795	49	OLFM1
3.539e-02	-3.34	positive regulation of cell junction assembly	biological process	GO:1901890	110	2	18204	49	GRID2,NRXN1
3.549e-02	-3.34	face	COSMIC cancer mutations	face	2139	11	16828	48	GABBR2,ZNF804A,GABRA6,GRIN2A,TRPM3,AK5,STXBP5L,LRRC7,CR2,HCN1,ASTN1
3.565e-02	-3.33	BRI3BP (BRI3 binding protein)	protein interactions	140707	118	2	19454	49	GABRD,SMPD3
3.565e-02	-3.33	MTX1 (metaxin 1)	protein interactions	4580	118	2	19454	49	KCNIP4,OPRL1
3.565e-02	-3.33	CDC7 (cell division cycle 7)	protein interactions	8317	118	2	19454	49	RBFOX3,RBFOX1
3.574e-02	-3.33	MAPK family signaling cascades	REACTOME pathways	R-HSA-5683057	290	3	10285	26	GRIN2A,PPP2R5B,KSR2
3.574e-02	-3.33	human chr2q32.1	chromosome location	human chr2q32.1	19	1	26134	50	ZNF804A
3.585e-02	-3.33	RABBD	prosite domains	PS50916	12	1	12186	37	RIMS2
3.585e-02	-3.33	V_SNARE	prosite domains	PS50892	12	1	12186	37	STXBP5L
3.593e-02	-3.33	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	49	LRRC7,ZNF804A,PPP2R5B,GRID2,PTPRG
3.618e-02	-3.32	purine deoxyribonucleosides salvage	BIOCYC pathways	HUMAN_PWY-7224	11	1	902	3	AK5
3.673e-02	-3.30	calcium ion binding	molecular function	GO:0005509	683	5	18094	49	NRXN1,PCLO,UNC13C,KCNIP4,RYR2
3.676e-02	-3.30	LRP6 (LDL receptor related protein 6)	protein interactions	4040	120	2	19454	49	GRIN2A,ST8SIA5
3.677e-02	-3.30	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	5	16828	48	ZFPM2,TRPM3,NRXN3,ASTN1,LRRC7
3.686e-02	-3.30	ASX_HYDROXYL	prosite domains	PS00010	100	2	12186	37	NRXN3,NRXN1
3.686e-02	-3.30	Laminin	gene3d domains	2.10.25.10	226	3	14470	47	ASTN1,NRXN1,NRXN3
3.700e-02	-3.30	IRS-mediated signalling	REACTOME pathways	R-HSA-112399	294	3	10285	26	KSR2,PPP2R5B,GRIN2A
3.704e-02	-3.30	deoxyribose phosphate biosynthetic process	biological process	GO:0046385	14	1	18204	49	AK5
3.704e-02	-3.30	synaptic vesicle priming	biological process	GO:0016082	14	1	18204	49	UNC13C
3.704e-02	-3.30	enamel mineralization	biological process	GO:0070166	14	1	18204	49	SLC24A4
3.704e-02	-3.30	protein localization to endosome	biological process	GO:0036010	14	1	18204	49	LRRC7
3.704e-02	-3.30	2'-deoxyribonucleotide biosynthetic process	biological process	GO:0009265	14	1	18204	49	AK5
3.704e-02	-3.30	response to epinephrine	biological process	GO:0071871	14	1	18204	49	RYR2
3.704e-02	-3.30	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	GO:0106072	14	1	18204	49	OPRL1
3.704e-02	-3.30	regulation of long-term synaptic depression	biological process	GO:1900452	14	1	18204	49	GRID2
3.704e-02	-3.30	chondrocyte differentiation involved in endochondral bone morphogenesis	biological process	GO:0003413	14	1	18204	49	SMPD3
3.704e-02	-3.30	negative regulation of adenylate cyclase activity	biological process	GO:0007194	14	1	18204	49	GABBR2
3.704e-02	-3.30	neurotransmitter receptor transport to postsynaptic membrane	biological process	GO:0098969	14	1	18204	49	LRRC7
3.704e-02	-3.30	deoxyribonucleotide biosynthetic process	biological process	GO:0009263	14	1	18204	49	AK5
3.704e-02	-3.30	complement receptor mediated signaling pathway	biological process	GO:0002430	14	1	18204	49	CR2
3.704e-02	-3.30	mechanosensory behavior	biological process	GO:0007638	14	1	18204	49	NRXN1
3.704e-02	-3.30	atrial cardiac muscle cell to AV node cell signaling	biological process	GO:0086026	14	1	18204	49	CACNA1C
3.704e-02	-3.30	atrial cardiac muscle cell action potential	biological process	GO:0086014	14	1	18204	49	CACNA1C
3.704e-02	-3.30	cellular response to oxidised low-density lipoprotein particle stimulus	biological process	GO:0140052	14	1	18204	49	SMPD3
3.704e-02	-3.30	response to light intensity	biological process	GO:0009642	14	1	18204	49	SLC24A4
3.704e-02	-3.30	primary amino compound metabolic process	biological process	GO:1901160	14	1	18204	49	GRIN2A
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	RYR2
3.714e-02	-3.29	CACNA1H (calcium voltage-gated channel subunit alpha1 H)	protein interactions	8912	15	1	19454	49	KCNMA1
3.714e-02	-3.29	IFNA1 (interferon alpha 1)	protein interactions	3439	15	1	19454	49	CR2
3.714e-02	-3.29	PNOC (prepronociceptin)	protein interactions	5368	15	1	19454	49	OPRL1
3.714e-02	-3.29	CCNG2 (cyclin G2)	protein interactions	901	15	1	19454	49	PPP2R5B
3.715e-02	-3.29	GPCR_3	interpro domains	IPR000337	14	1	18521	50	GABBR2
3.715e-02	-3.29	Recoverin	interpro domains	IPR028846	14	1	18521	50	KCNIP4
3.715e-02	-3.29	GPCR_3_CS	interpro domains	IPR017979	14	1	18521	50	GABBR2
3.717e-02	-3.29	regulation of regulated secretory pathway	biological process	GO:1903305	113	2	18204	49	RIMS2,RIMS4
3.717e-02	-3.29	heart process	biological process	GO:0003015	113	2	18204	49	RYR2,CACNA1C
3.727e-02	-3.29	mRNA regulatory element binding translation repressor activity	molecular function	GO:0000900	14	1	18094	49	CELF4
3.727e-02	-3.29	protein kinase A catalytic subunit binding	molecular function	GO:0034236	14	1	18094	49	RYR2
3.727e-02	-3.29	high voltage-gated calcium channel activity	molecular function	GO:0008331	14	1	18094	49	CACNA1C
3.728e-02	-3.29	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	REACTOME pathways	R-HSA-4839743	15	1	10285	26	PPP2R5B
3.728e-02	-3.29	S45 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358751	15	1	10285	26	PPP2R5B
3.728e-02	-3.29	T41 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358752	15	1	10285	26	PPP2R5B
3.728e-02	-3.29	Misspliced GSK3beta mutants stabilize beta-catenin	REACTOME pathways	R-HSA-5339716	15	1	10285	26	PPP2R5B
3.728e-02	-3.29	S37 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358749	15	1	10285	26	PPP2R5B
3.728e-02	-3.29	S33 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358747	15	1	10285	26	PPP2R5B
3.759e-02	-3.28	human chr18q12.2	chromosome location	human chr18q12.2	20	1	26134	50	CELF4
3.796e-02	-3.27	Insulin receptor signalling cascade	REACTOME pathways	R-HSA-74751	297	3	10285	26	PPP2R5B,GRIN2A,KSR2
3.828e-02	-3.26	IRS-related events triggered by IGF1R	REACTOME pathways	R-HSA-2428928	298	3	10285	26	KSR2,PPP2R5B,GRIN2A
3.828e-02	-3.26	IGF1R signaling cascade	REACTOME pathways	R-HSA-2428924	298	3	10285	26	PPP2R5B,GRIN2A,KSR2
3.844e-02	-3.26	EXOC7 (exocyst complex component 7)	protein interactions	23265	123	2	19454	49	DLG3,INSYN1
3.859e-02	-3.25	Reelin signaling pathway	Pathway Interaction DB	reelinpathway	29	1	2226	3	GRIN2A
3.860e-02	-3.25	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME pathways	R-HSA-2404192	299	3	10285	26	PPP2R5B,GRIN2A,KSR2
3.863e-02	-3.25	Hypertrophic cardiomyopathy (HCM)	KEGG pathways	hsa05410	83	2	7161	27	CACNA1C,RYR2
3.863e-02	-3.25	Hypertrophic cardiomyopathy (HCM)	KEGG pathways	ko05410	83	2	7161	27	RYR2,CACNA1C
3.878e-02	-3.25	OLF	prosite domains	PS51132	13	1	12186	37	OLFM1
3.901e-02	-3.24	HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)	protein interactions	3156	124	2	19454	49	MARCHF4,GABRA6
3.901e-02	-3.24	EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1)	protein interactions	58513	124	2	19454	49	INSYN1,LRRC7
3.956e-02	-3.23	CR2 (complement C3d receptor 2)	protein interactions	1380	16	1	19454	49	CR2
3.956e-02	-3.23	C1orf122 (chromosome 1 open reading frame 122)	protein interactions	127687	16	1	19454	49	INSYN1
3.956e-02	-3.23	SYT4 (synaptotagmin 4)	protein interactions	6860	16	1	19454	49	NRXN1
3.956e-02	-3.23	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	49	NRXN1
3.956e-02	-3.23	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	49	NRXN1
3.956e-02	-3.23	WASH6P (WASP family homolog 6, pseudogene)	protein interactions	653440	16	1	19454	49	INSYN1
3.956e-02	-3.23	TAMALIN (trafficking regulator and scaffold protein tamalin)	protein interactions	160622	16	1	19454	49	GABBR2
3.956e-02	-3.23	AKAP6 (A-kinase anchoring protein 6)	protein interactions	9472	16	1	19454	49	RYR2
3.964e-02	-3.23	heart valve formation	biological process	GO:0003188	15	1	18204	49	OLFM1
3.964e-02	-3.23	atrial cardiac muscle cell to AV node cell communication	biological process	GO:0086066	15	1	18204	49	CACNA1C
3.964e-02	-3.23	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	49	KCNMA1
3.964e-02	-3.23	dense core granule localization	biological process	GO:0032253	15	1	18204	49	UNC13C
3.964e-02	-3.23	complement activation, alternative pathway	biological process	GO:0006957	15	1	18204	49	CR2
3.964e-02	-3.23	apical protein localization	biological process	GO:0045176	15	1	18204	49	HCN1
3.964e-02	-3.23	positive regulation of exosomal secretion	biological process	GO:1903543	15	1	18204	49	SMPD3
3.964e-02	-3.23	negative regulation of cyclase activity	biological process	GO:0031280	15	1	18204	49	GABBR2
3.964e-02	-3.23	negative regulation of B cell mediated immunity	biological process	GO:0002713	15	1	18204	49	CR2
3.964e-02	-3.23	neurotransmitter receptor transport to plasma membrane	biological process	GO:0098877	15	1	18204	49	LRRC7
3.964e-02	-3.23	negative regulation of immunoglobulin mediated immune response	biological process	GO:0002890	15	1	18204	49	CR2
3.964e-02	-3.23	establishment of protein localization to postsynaptic membrane	biological process	GO:1903540	15	1	18204	49	LRRC7
3.964e-02	-3.23	endosome to plasma membrane protein transport	biological process	GO:0099638	15	1	18204	49	LRRC7
3.964e-02	-3.23	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	49	RYR2
3.964e-02	-3.23	response to caffeine	biological process	GO:0031000	15	1	18204	49	RYR2
3.973e-02	-3.23	cell adhesion	biological process	GO:0007155	942	6	18204	49	DLG3,LRRC7,NRXN1,NRXN3,ASTN1,GRID2
3.975e-02	-3.23	Sialyl_trans	interpro domains	IPR012163	15	1	18521	50	ST8SIA5
3.995e-02	-3.22	liposarcoma	COSMIC cancer mutations	liposarcoma	111	2	16828	48	GABRA6,HCN1
4.002e-02	-3.22	MACPF	smart domains	SM00457	12	1	9717	33	ASTN1
4.061e-02	-3.20	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	47	16828	48	NRXN3,DLG3,GABBR2,KCNIP4,TTC9B,CELF6,RBFOX1,STXBP5L,R3HDM1,ST8SIA5,GABRB2,RIMS2,CPLX1,RIMS4,AK5,OLFM1,GABRD,MYT1L,GALNT9,TRPM3,CELF5,IL1RAPL2,GABRA1,CELF4,GRIN2A,UNC13C,ZFPM2,LRRC7,GRID2,RYR2,ZNF804A,SLC24A4,OPRL1,KSR2,CR2,RGS7,CACNA1C,KCNT1,ASTN1,GABRA6,SMPD3,PCLO,HCN1,PTPRG,KCNMA1,PPP2R5B,NRXN1
4.087e-02	-3.20	Ganglio Sphingolipid Metabolism	WikiPathways	WP1423	13	1	5310	17	ST8SIA5
4.087e-02	-3.20	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	1	5310	17	RYR2
4.116e-02	-3.19	regulation of localization	biological process	GO:0032879	2028	10	18204	49	RIMS2,RYR2,KCNIP4,GRIN2A,CACNA1C,CPLX1,RGS7,PCLO,RIMS4,SMPD3
4.127e-02	-3.19	human chr5p12	chromosome location	human chr5p12	22	1	26134	50	HCN1
4.144e-02	-3.18	striated muscle contraction	biological process	GO:0006941	120	2	18204	49	RYR2,CACNA1C
4.156e-02	-3.18	regulation of cell communication	biological process	GO:0010646	3541	15	18204	49	NRXN1,RIMS2,CPLX1,UNC13C,OPRL1,SMPD3,PPP2R5B,GRID2,CELF4,GRIN2A,RYR2,KSR2,RIMS4,RGS7,SLC24A4
4.198e-02	-3.17	LY6D (lymphocyte antigen 6 family member D)	protein interactions	8581	17	1	19454	49	GRIN2A
4.198e-02	-3.17	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	49	NRXN3
4.198e-02	-3.17	CPNE6 (copine 6)	protein interactions	9362	17	1	19454	49	AK5
4.198e-02	-3.17	GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C)	protein interactions	2905	17	1	19454	49	DLG3
4.203e-02	-3.17	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	11	16828	48	PCLO,PTPRG,GRIN2A,ASTN1,NRXN3,KSR2,SMPD3,CR2,STXBP5L,GABBR2,GABRA6
4.207e-02	-3.17	renal system process	biological process	GO:0003014	121	2	18204	49	KCNMA1,OPRL1
4.215e-02	-3.17	Beta-catenin phosphorylation cascade	REACTOME pathways	R-HSA-196299	17	1	10285	26	PPP2R5B
4.215e-02	-3.17	CREB phosphorylation through the activation of CaMKII	REACTOME pathways	R-HSA-442729	17	1	10285	26	GRIN2A
4.215e-02	-3.17	Platelet sensitization by LDL	REACTOME pathways	R-HSA-432142	17	1	10285	26	PPP2R5B
4.215e-02	-3.17	Unblocking of NMDA receptor, glutamate binding and activation	REACTOME pathways	R-HSA-438066	17	1	10285	26	GRIN2A
4.215e-02	-3.17	Acetylcholine Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-264642	17	1	10285	26	CPLX1
4.223e-02	-3.16	estrous cycle	biological process	GO:0044849	16	1	18204	49	OPRL1
4.223e-02	-3.16	glutamatergic neuron differentiation	biological process	GO:1905962	16	1	18204	49	GRID2
4.223e-02	-3.16	purine deoxyribonucleotide metabolic process	biological process	GO:0009151	16	1	18204	49	AK5
4.223e-02	-3.16	sphingolipid mediated signaling pathway	biological process	GO:0090520	16	1	18204	49	SMPD3
4.223e-02	-3.16	cardiac left ventricle morphogenesis	biological process	GO:0003214	16	1	18204	49	RYR2
4.223e-02	-3.16	regulation of postsynaptic specialization assembly	biological process	GO:0099150	16	1	18204	49	GRID2
4.223e-02	-3.16	G1 to G0 transition	biological process	GO:0070314	16	1	18204	49	SMPD3
4.235e-02	-3.16	Guanylate_kinase_CS	interpro domains	IPR020590	16	1	18521	50	DLG3
4.235e-02	-3.16	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	50	HCN1
4.235e-02	-3.16	Endo/exonuclease/phosphatase	interpro domains	IPR005135	16	1	18521	50	SMPD3
4.248e-02	-3.16	glutamate-gated receptor activity	molecular function	GO:0004970	16	1	18094	49	GRIN2A
4.248e-02	-3.16	NAD+ nucleotidase, cyclic ADP-ribose generating	molecular function	GO:0061809	16	1	18094	49	IL1RAPL2
4.248e-02	-3.16	protein phosphatase activator activity	molecular function	GO:0072542	16	1	18094	49	PPP2R5B
4.249e-02	-3.16	PKP1 (plakophilin 1)	protein interactions	5317	130	2	19454	49	RBFOX1,HCN1
4.259e-02	-3.16	secretory	COSMIC cancer mutations	secretory	115	2	16828	48	GRIN2A,CACNA1C
4.259e-02	-3.16	meninges-meningioma-secretory	COSMIC cancer mutations	meninges-meningioma-secretory	115	2	16828	48	CACNA1C,GRIN2A
4.266e-02	-3.15	superpathway of purine nucleotides de novo biosynthesis I	BIOCYC pathways	META_PWY-841	13	1	902	3	AK5
4.266e-02	-3.15	superpathway of purine nucleotide salvage	BIOCYC pathways	META_PWY66-409	13	1	902	3	AK5
4.267e-02	-3.15	neuron projection terminus	cellular component	GO:0044306	128	2	19108	49	UNC13C,CPLX1
4.270e-02	-3.15	odontogenesis	biological process	GO:0042476	122	2	18204	49	SMPD3,SLC24A4
4.280e-02	-3.15	INTRLKN1R1F	prints domains	PR01537	12	1	5227	19	IL1RAPL2
4.280e-02	-3.15	EAGCHANLFMLY	prints domains	PR01463	12	1	5227	19	HCN1
4.311e-02	-3.14	human chr2p25.3	chromosome location	human chr2p25.3	23	1	26134	50	MYT1L
4.318e-02	-3.14	Exo_endo_phos	pfam domains	PF03372	16	1	17795	49	SMPD3
4.329e-02	-3.14	OLF	smart domains	SM00284	13	1	9717	33	OLFM1
4.367e-02	-3.13	HAL (histidine ammonia-lyase)	protein interactions	3034	132	2	19454	49	GALNT9,HCN1
4.385e-02	-3.13	Dilated cardiomyopathy	KEGG pathways	ko05414	89	2	7161	27	RYR2,CACNA1C
4.385e-02	-3.13	Dilated cardiomyopathy	KEGG pathways	hsa05414	89	2	7161	27	CACNA1C,RYR2
4.388e-02	-3.13	Z disc	cellular component	GO:0030018	130	2	19108	49	RYR2,CACNA1C
4.393e-02	-3.13	central_nervous_system-brain-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligoastrocytoma_Grade_III	117	2	16828	48	HCN1,RYR2
4.393e-02	-3.13	fat	COSMIC cancer mutations	fat	117	2	16828	48	GABRA6,HCN1
4.427e-02	-3.12	GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1)	protein interactions	2554	133	2	19454	49	GABRB2,GABRA1
4.440e-02	-3.11	RYR3 (ryanodine receptor 3)	protein interactions	6263	18	1	19454	49	RYR2
4.440e-02	-3.11	GNA14 (G protein subunit alpha 14)	protein interactions	9630	18	1	19454	49	OPRL1
4.440e-02	-3.11	RHBDL1 (rhomboid like 1)	protein interactions	9028	18	1	19454	49	DLG3
4.440e-02	-3.11	protein-containing complex	cellular component	GO:0032991	6542	23	19108	49	KCNMA1,CACNA1C,GABRB2,KCNIP4,GRIN2A,CELF6,STXBP5L,CELF5,RYR2,GABRA6,RGS7,GABRA1,CELF4,GABRD,DLG3,PPP2R5B,HCN1,GABBR2,MYT1L,GRID2,ZFPM2,CPLX1,CR2
4.457e-02	-3.11	cGMP effects	REACTOME pathways	R-HSA-418457	18	1	10285	26	KCNMA1
4.457e-02	-3.11	Serotonin Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-181429	18	1	10285	26	CPLX1
4.457e-02	-3.11	Norepinephrine Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-181430	18	1	10285	26	CPLX1
4.469e-02	-3.11	flank	COSMIC cancer mutations	flank	16	1	16828	48	GRIN2A
4.481e-02	-3.11	regulation of excitatory synapse assembly	biological process	GO:1904889	17	1	18204	49	GRID2
4.481e-02	-3.11	negative regulation of humoral immune response	biological process	GO:0002921	17	1	18204	49	CR2
4.481e-02	-3.11	N-glycan processing	biological process	GO:0006491	17	1	18204	49	ST8SIA5
4.481e-02	-3.11	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	49	CACNA1C
4.481e-02	-3.11	positive regulation of sequestering of calcium ion	biological process	GO:0051284	17	1	18204	49	RYR2
4.481e-02	-3.11	regulation of postsynaptic density organization	biological process	GO:1905874	17	1	18204	49	GRID2
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRG
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRG
4.493e-02	-3.10	G-protein_gamma-like_dom	interpro domains	IPR015898	17	1	18521	50	RGS7
4.493e-02	-3.10	GGL_sf	interpro domains	IPR036284	17	1	18521	50	RGS7
4.493e-02	-3.10	Znf_RING-CH	interpro domains	IPR011016	17	1	18521	50	MARCHF4
4.507e-02	-3.10	nucleoside diphosphate kinase activity	molecular function	GO:0004550	17	1	18094	49	AK5
4.507e-02	-3.10	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	49	PTPRG
4.507e-02	-3.10	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	49	PTPRG
4.519e-02	-3.10	protein phosphatase type 2A complex	cellular component	GO:0000159	18	1	19108	49	PPP2R5B
4.525e-02	-3.10	response to ethanol	biological process	GO:0045471	126	2	18204	49	GRIN2A,RGS7
4.569e-02	-3.09	muscle system process	biological process	GO:0003012	297	3	18204	49	KCNMA1,CACNA1C,RYR2
4.581e-02	-3.08	Carb_anhydrase	pfam domains	PF00194	17	1	17795	49	PTPRG
4.581e-02	-3.08	G-gamma	pfam domains	PF00631	17	1	17795	49	RGS7
4.590e-02	-3.08	cardiac ventricle development	biological process	GO:0003231	127	2	18204	49	RYR2,ZFPM2
4.590e-02	-3.08	cardiac chamber morphogenesis	biological process	GO:0003206	127	2	18204	49	RYR2,ZFPM2
4.608e-02	-3.08	TRIM13 (tripartite motif containing 13)	protein interactions	10206	136	2	19454	49	CACNA1C,MARCHF4
4.645e-02	-3.07	Signaling by Insulin receptor	REACTOME pathways	R-HSA-74752	322	3	10285	26	KSR2,PPP2R5B,GRIN2A
4.652e-02	-3.07	cellular response to organonitrogen compound	biological process	GO:0071417	505	4	18204	49	HCN1,GABRB2,RYR2,GRIN2A
4.669e-02	-3.06	C3 (complement C3)	protein interactions	718	137	2	19454	49	CR2,HCN1
4.681e-02	-3.06	LRRTM3 (leucine rich repeat transmembrane neuronal 3)	protein interactions	347731	19	1	19454	49	NRXN3
4.681e-02	-3.06	TCF7 (transcription factor 7)	protein interactions	6932	19	1	19454	49	RBFOX3
4.681e-02	-3.06	KCNG1 (potassium voltage-gated channel modifier subfamily G member 1)	protein interactions	3755	19	1	19454	49	MARCHF4
4.681e-02	-3.06	HIGD2A (HIG1 hypoxia inducible domain family member 2A)	protein interactions	192286	19	1	19454	49	GRIN2A
4.681e-02	-3.06	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	49	NRXN1
4.681e-02	-3.06	OSM (oncostatin M)	protein interactions	5008	19	1	19454	49	TRPM3
4.681e-02	-3.06	ANKRD13C (ankyrin repeat domain 13C)	protein interactions	81573	19	1	19454	49	MARCHF4
4.681e-02	-3.06	HSFX1 (heat shock transcription factor family, X-linked 1)	protein interactions	100506164	19	1	19454	49	RBFOX1
4.699e-02	-3.06	Ras activation uopn Ca2+ infux through NMDA receptor	REACTOME pathways	R-HSA-442982	19	1	10285	26	GRIN2A
4.699e-02	-3.06	GABA synthesis, release, reuptake and degradation	REACTOME pathways	R-HSA-888590	19	1	10285	26	CPLX1
4.737e-02	-3.05	circulatory system process	biological process	GO:0003013	508	4	18204	49	RYR2,OPRL1,KCNMA1,CACNA1C
4.738e-02	-3.05	secretory granule localization	biological process	GO:0032252	18	1	18204	49	UNC13C
4.738e-02	-3.05	regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002923	18	1	18204	49	CR2
4.738e-02	-3.05	negative regulation of lyase activity	biological process	GO:0051350	18	1	18204	49	GABBR2
4.752e-02	-3.05	CNMP_BINDING_1	prosite domains	PS00888	16	1	12186	37	HCN1
4.752e-02	-3.05	GUANYLATE_KINASE_1	prosite domains	PS00856	16	1	12186	37	DLG3
4.766e-02	-3.04	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	49	RYR2
4.792e-02	-3.04	EXOC3 (exocyst complex component 3)	protein interactions	11336	139	2	19454	49	DLG3,INSYN1
4.792e-02	-3.04	TMEM131 (transmembrane protein 131)	protein interactions	23505	139	2	19454	49	ST8SIA5,GABRD
4.824e-02	-3.03	animal organ morphogenesis	biological process	GO:0009887	988	6	18204	49	RYR2,ZFPM2,OLFM1,SMPD3,SLC24A4,HCN1
4.852e-02	-3.03	response to calcium ion	biological process	GO:0051592	131	2	18204	49	KCNMA1,RYR2
4.900e-02	-3.02	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	4	16828	48	PPP2R5B,ASTN1,IL1RAPL2,RYR2
4.900e-02	-3.02	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	4	16828	48	PPP2R5B,ASTN1,IL1RAPL2,RYR2
4.921e-02	-3.01	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	1	19454	49	NRXN1
4.921e-02	-3.01	GGT1 (gamma-glutamyltransferase 1)	protein interactions	2678	20	1	19454	49	KCNMA1
4.921e-02	-3.01	ABCA7 (ATP binding cassette subfamily A member 7)	protein interactions	10347	20	1	19454	49	MARCHF4
4.929e-02	-3.01	metal ion binding	molecular function	GO:0046872	4239	17	18094	49	NRXN1,CACNA1C,ZNF804A,GRIN2A,NRXN3,GALNT9,MYT1L,ZFPM2,SMPD3,MARCHF4,RYR2,PCLO,UNC13C,KCNMA1,RIMS2,KSR2,KCNIP4
4.931e-02	-3.01	Pancreatic secretion	KEGG pathways	hsa04972	95	2	7161	27	KCNMA1,RYR2
4.931e-02	-3.01	Pancreatic secretion	KEGG pathways	ko04972	95	2	7161	27	RYR2,KCNMA1
4.935e-02	-3.01	VEGFA-VEGFR2 Pathway	REACTOME pathways	R-HSA-4420097	330	3	10285	26	KSR2,PPP2R5B,GRIN2A
4.937e-02	-3.01	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	4	18204	49	NRXN1,GRID2,PPP2R5B,SMPD3
4.946e-02	-3.01	knee	COSMIC cancer mutations	knee	125	2	16828	48	GRIN2A,RYR2
4.957e-02	-3.00	acinar_carcinoma	COSMIC cancer mutations	acinar_carcinoma	1978	10	16828	48	GRIN2A,ZFPM2,ZNF804A,SLC24A4,MYT1L,TRPM3,KSR2,PTPRG,PCLO,NRXN3
4.957e-02	-3.00	pancreas-carcinoma-acinar_carcinoma	COSMIC cancer mutations	pancreas-carcinoma-acinar_carcinoma	1978	10	16828	48	NRXN3,PTPRG,PCLO,MYT1L,TRPM3,KSR2,ZFPM2,GRIN2A,ZNF804A,SLC24A4
4.976e-02	-3.00	GPCRMGR	prints domains	PR00248	14	1	5227	19	GABBR2
4.978e-02	-3.00	OPRM1 (opioid receptor mu 1)	protein interactions	4988	142	2	19454	49	CPLX1,OPRL1
4.985e-02	-3.00	regulation of sequestering of calcium ion	biological process	GO:0051282	133	2	18204	49	RYR2,CACNA1C
4.992e-02	-3.00	salivary_gland-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma-adenoid_cystic_carcinoma	488	4	16828	48	ASTN1,GABRA1,RYR2,PTPRG
4.995e-02	-3.00	regulation of exosomal secretion	biological process	GO:1903541	19	1	18204	49	SMPD3
4.995e-02	-3.00	excretion	biological process	GO:0007588	19	1	18204	49	KCNMA1
4.995e-02	-3.00	presynapse assembly	biological process	GO:0099054	19	1	18204	49	PCLO
4.995e-02	-3.00	sphingomyelin metabolic process	biological process	GO:0006684	19	1	18204	49	SMPD3