Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
3.485e-15	-33.29	nucleoside-triphosphatase regulator activity	molecular function	GO:0060589	491	17	18094	48	DOCK1,DENND1B,RIN3,GIT2,ELMO1,DOCK2,VAV3,ARHGAP27,DOCK10,WAS,DOCK8,RGS14,ARHGAP33,PREX1,GMIP,TBC1D8,AKAP13
3.485e-15	-33.29	GTPase regulator activity	molecular function	GO:0030695	491	17	18094	48	GIT2,RIN3,DENND1B,DOCK1,VAV3,ARHGAP27,DOCK2,ELMO1,DOCK10,AKAP13,TBC1D8,GMIP,PREX1,RGS14,ARHGAP33,WAS,DOCK8
6.626e-12	-25.74	enzyme binding	molecular function	GO:0019899	2086	25	18094	48	PLCG2,DENND1B,GIT2,SLC4A2,RIN3,SYK,IRF5,CSF1R,CD74,WAS,AKAP13,MICAL1,DOCK1,IL6R,APOE,DOCK2,HIF1A,PRKCD,PTPN6,DOCK10,NEK6,SKAP1,ARHGAP33,RGS14,PREX1
2.021e-11	-24.63	regulation of immune system process	biological process	GO:0002682	1584	22	18204	49	DOCK8,RHBDF2,ADCY7,CD74,PRKCD,IL6R,CSF1R,APOE,HIF1A,PIK3CB,RIN3,IRF5,PLCG2,SLC4A2,DENND1B,GSDME,SYK,PTPN6,SKAP1,VAV3,WAS,FYB1
2.986e-11	-24.23	enzyme regulator activity	molecular function	GO:0030234	1305	20	18094	48	WAS,ARHGAP33,DOCK8,RGS14,PREX1,TBC1D8,GMIP,AKAP13,PRKCD,DOCK10,ELMO1,PIK3R5,DOCK2,APOE,VAV3,ARHGAP27,DOCK1,DENND1B,RIN3,GIT2
3.335e-11	-24.12	cell activation	biological process	GO:0001775	725	16	18204	49	WAS,VAV3,SBNO2,PLCG2,DOCK10,PTPN6,SYK,IL6R,PIK3CB,DOCK8,WDFY4,DOCK2,PRKCD,SEMA4A,CD74,PREX1
4.424e-11	-23.84	regulation of intracellular signal transduction	biological process	GO:1902531	1832	23	18204	49	RGS14,APOE,HIF1A,PIK3CB,CSF1R,CD74,PREX1,DOCK2,GMIP,PRKCD,ARHGAP27,AKAP13,DOCK8,PIK3R5,NRK,P2RY6,VAV3,GSDME,GIT2,PTPN6,NEK6,SYK,PLCG2
7.960e-11	-23.25	PH-like_dom_sf	interpro domains	IPR011993	431	13	18521	50	TBC1D8,WAS,SKAP1,VAV3,DOCK10,WDFY4,PLCG2,CARMIL3,ARHGAP27,AKAP13,ELMO1,PREX1,IPCEF1
1.040e-10	-22.99	GTPase activator activity	molecular function	GO:0005096	273	11	18094	48	GMIP,TBC1D8,PREX1,RGS14,ARHGAP33,GIT2,RIN3,DOCK1,ARHGAP27,VAV3,DOCK2
1.342e-10	-22.73	signal transduction	biological process	GO:0007165	4637	34	18204	49	CD74,ADCY7,SEMA4A,GMIP,ARHGAP27,P2RY2,AKAP13,ARHGAP33,DOCK8,HIF1A,IL6R,CSF1R,DOCK1,SYK,PLCG2,DENND1B,PIK3R5,P2RY6,VAV3,FYB1,PREX1,DOCK2,PRKCD,RGS14,APOE,RIN3,PIK3CB,ELMO1,DOCK10,PTPN6,MICAL1,IRF5,SKAP1,WAS
1.838e-10	-22.42	regulation of response to stimulus	biological process	GO:0048583	4104	32	18204	49	HIF1A,IL6R,CSF1R,GMIP,RHBDF2,ADCY7,CD74,DOCK8,AKAP13,ARHGAP27,P2RY6,PIK3R5,FYB1,VAV3,SBNO2,SYK,NEK6,GIT2,GSDME,DENND1B,PLCG2,PIK3CB,RIN3,APOE,RGS14,PRKCD,DOCK2,PREX1,NRK,WAS,SKAP1,PTPN6
2.527e-10	-22.10	lymphocyte activation	biological process	GO:0046649	476	13	18204	49	PREX1,CD74,PRKCD,SEMA4A,DOCK2,WDFY4,DOCK8,IL6R,SYK,PTPN6,DOCK10,PLCG2,WAS
3.502e-10	-21.77	leukocyte activation	biological process	GO:0045321	599	14	18204	49	IL6R,WDFY4,DOCK8,PREX1,CD74,SEMA4A,PRKCD,DOCK2,SBNO2,WAS,PLCG2,SYK,DOCK10,PTPN6
3.565e-10	-21.75	guanyl-nucleotide exchange factor activity	molecular function	GO:0005085	228	10	18094	48	PREX1,ELMO1,DOCK8,AKAP13,VAV3,DOCK2,DENND1B,DOCK1,DOCK10,RIN3
4.289e-10	-21.57	Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME pathways	R-HSA-2029480	86	8	10285	36	PRKCD,PIK3CB,PLCG2,ELMO1,SYK,VAV3,DOCK1,WAS
4.505e-10	-21.52	endocytosis	biological process	GO:0006897	499	13	18204	49	P2RY6,VAV3,SYK,DOCK1,DENND1B,APOE,PIK3CB,RIN3,ELMO1,PRKCD,DOCK2,ARHGAP27,MYO1F
5.381e-10	-21.34	intracellular signal transduction	biological process	GO:0035556	1505	20	18204	49	DOCK1,DOCK10,PTPN6,SYK,PLCG2,PIK3R5,WAS,VAV3,DOCK2,PRKCD,GMIP,PREX1,ADCY7,DOCK8,ARHGAP33,AKAP13,PIK3CB,APOE,HIF1A,ELMO1
9.066e-10	-20.82	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	gene3d domains	2.30.29.30	431	13	14470	48	DOCK10,SKAP1,ELMO1,WAS,VAV3,CARMIL3,AKAP13,ARHGAP27,IPCEF1,TBC1D8,WDFY4,PLCG2,PREX1
9.898e-10	-20.73	signaling	biological process	GO:0023052	4968	34	18204	49	SKAP1,WAS,DOCK10,PTPN6,MICAL1,IRF5,RGS14,APOE,RIN3,PIK3CB,ELMO1,PREX1,DOCK2,PRKCD,PIK3R5,P2RY6,VAV3,FYB1,DOCK1,SYK,PLCG2,DENND1B,HIF1A,IL6R,CSF1R,CD74,ADCY7,SEMA4A,GMIP,ARHGAP27,P2RY2,ARHGAP33,AKAP13,DOCK8
1.260e-09	-20.49	cell communication	biological process	GO:0007154	5010	34	18204	49	SYK,DOCK1,DENND1B,PLCG2,P2RY6,PIK3R5,FYB1,VAV3,GMIP,SEMA4A,ADCY7,CD74,DOCK8,AKAP13,ARHGAP33,ARHGAP27,P2RY2,HIF1A,IL6R,CSF1R,PTPN6,DOCK10,IRF5,MICAL1,WAS,SKAP1,PRKCD,DOCK2,PREX1,PIK3CB,RIN3,APOE,RGS14,ELMO1
1.691e-09	-20.20	immune system process	biological process	GO:0002376	1991	22	18204	49	SKAP1,WAS,IRF5,PTPN6,DOCK10,PREX1,DOCK2,PRKCD,VAV3,SBNO2,FYB1,PIK3R5,PLCG2,DENND1B,SYK,CSF1R,IL6R,HIF1A,WDFY4,DOCK8,CD74,SEMA4A
2.261e-09	-19.91	plasma membrane	cellular component	GO:0005886	5538	35	19108	50	DOCK8,ADCY7,DOCK1,IPCEF1,CARMIL3,PTPN6,WAS,RHBDF2,PIK3R5,CD74,DOCK2,P2RY6,CSF1R,MICAL1,GLIPR1,SEMA4A,ELMO1,GMIP,PREX1,FYB1,IL6R,SLC4A2,VAV3,P2RY2,RGS14,APOE,ARHGAP33,PARVG,PLCG2,SYK,GSDME,MYO1F,SKAP1,PIK3CB,PRKCD
2.422e-09	-19.84	SH3 Domains	gene3d domains	2.30.30.40	223	10	14470	48	SKAP1,DOCK1,VAV3,ARHGAP33,ELMO1,FYB1,ARHGAP27,MYO1F,DOCK2,PLCG2
2.652e-09	-19.75	molecular function regulator activity	molecular function	GO:0098772	2079	22	18094	48	PRKCD,DOCK10,HIF1A,AKAP13,WAS,DOCK8,RGS14,ARHGAP33,PREX1,TBC1D8,GMIP,RIN3,GIT2,DOCK1,DENND1B,APOE,DOCK2,ARHGAP27,VAV3,SEMA4A,ELMO1,PIK3R5
2.791e-09	-19.70	intracellular signaling cassette	biological process	GO:0141124	837	15	18204	49	ELMO1,PIK3CB,APOE,DOCK8,AKAP13,ARHGAP33,DOCK2,WAS,VAV3,PIK3R5,PLCG2,SYK,DOCK1,DOCK10,PTPN6
3.352e-09	-19.51	enzyme activator activity	molecular function	GO:0008047	599	13	18094	48	RIN3,GIT2,DOCK1,APOE,DOCK2,ARHGAP27,VAV3,PRKCD,ARHGAP33,RGS14,PREX1,GMIP,TBC1D8
4.572e-09	-19.20	positive regulation of catalytic activity	biological process	GO:0043085	868	15	18204	49	P2RY6,TBC1D8,PIK3R5,SYK,DOCK10,APOE,HIF1A,CSF1R,IL6R,GMIP,PRKCD,PREX1,CD74,DOCK8,ARHGAP27
4.712e-09	-19.17	cell periphery	cellular component	GO:0071944	6020	36	19108	50	PTPN6,WAS,CD74,PIK3R5,RHBDF2,DOCK2,MICAL1,CSF1R,P2RY6,ADCY7,DOCK8,IPCEF1,DOCK1,CARMIL3,PARVG,APOE,AKAP13,ARHGAP33,P2RY2,RGS14,VAV3,PLCG2,SYK,PRKCD,PIK3CB,SKAP1,MYO1F,GSDME,GLIPR1,FYB1,PREX1,GMIP,ELMO1,SEMA4A,IL6R,SLC4A2
4.749e-09	-19.17	SH3-like_dom_sf	interpro domains	IPR036028	212	9	18521	50	ARHGAP33,VAV3,SKAP1,FYB1,MYO1F,ARHGAP27,DOCK2,PLCG2,DOCK1
4.970e-09	-19.12	LCP2 (lymphocyte cytosolic protein 2)	protein interactions	3937	54	6	19454	50	VAV3,WAS,SYK,PLCG2,FYB1,PTPN6
5.183e-09	-19.08	immune effector process	biological process	GO:0002252	389	11	18204	49	IL6R,PRKCD,SEMA4A,DOCK2,CD74,SBNO2,VAV3,PLCG2,SYK,DOCK10,PTPN6
5.925e-09	-18.94	cellular response to stimulus	biological process	GO:0051716	6307	37	18204	49	IL6R,CSF1R,HIF1A,P2RY2,ARHGAP27,ARHGAP33,AKAP13,DOCK8,CD74,ADCY7,GMIP,SEMA4A,VAV3,SBNO2,FYB1,PIK3R5,P2RY6,PLCG2,IPCEF1,DENND1B,GSDME,DOCK1,SYK,ELMO1,RGS14,APOE,RIN3,PIK3CB,PREX1,DOCK2,PRKCD,SKAP1,WAS,MICAL1,IRF5,PTPN6,DOCK10
7.103e-09	-18.76	SH3_domain	interpro domains	IPR001452	222	9	18521	50	VAV3,ARHGAP33,FYB1,SKAP1,MYO1F,ARHGAP27,PLCG2,DOCK2,DOCK1
7.159e-09	-18.75	regulation of small GTPase mediated signal transduction	biological process	GO:0051056	306	10	18204	49	PREX1,GIT2,GMIP,DOCK2,AKAP13,ARHGAP27,DOCK8,APOE,PIK3CB,VAV3
9.438e-09	-18.48	T cell activation	biological process	GO:0042110	315	10	18204	49	WDFY4,DOCK8,CD74,PREX1,PTPN6,DOCK2,SYK,SEMA4A,IL6R,WAS
1.295e-08	-18.16	leukocyte differentiation	biological process	GO:0002521	425	11	18204	49	DOCK2,SEMA4A,CD74,PREX1,CSF1R,IL6R,DOCK10,SYK,SLC4A2,PLCG2,SBNO2
1.529e-08	-18.00	DOCKER_Lobe_C	interpro domains	IPR046773	11	4	18521	50	DOCK8,DOCK2,DOCK1,DOCK10
1.529e-08	-18.00	DOCKER_Lobe_B	interpro domains	IPR046770	11	4	18521	50	DOCK1,DOCK10,DOCK8,DOCK2
1.529e-08	-18.00	DOCK_C_lobe_C	interpro domains	IPR043162	11	4	18521	50	DOCK8,DOCK2,DOCK1,DOCK10
1.529e-08	-18.00	DOCK_C_lobe_A	interpro domains	IPR043161	11	4	18521	50	DOCK2,DOCK8,DOCK10,DOCK1
1.529e-08	-18.00	DOCK	interpro domains	IPR026791	11	4	18521	50	DOCK2,DOCK8,DOCK10,DOCK1
1.529e-08	-18.00	DOCKER_Lobe_A	interpro domains	IPR046769	11	4	18521	50	DOCK2,DOCK8,DOCK10,DOCK1
1.529e-08	-18.00	C2_DOCK-type_domain	interpro domains	IPR027007	11	4	18521	50	DOCK1,DOCK10,DOCK8,DOCK2
1.529e-08	-18.00	DOCKER_dom	interpro domains	IPR027357	11	4	18521	50	DOCK1,DOCK10,DOCK8,DOCK2
1.539e-08	-17.99	regulation of MAPK cascade	biological process	GO:0043408	669	13	18204	49	CSF1R,APOE,RGS14,PIK3CB,CD74,PRKCD,PIK3R5,NRK,P2RY6,PLCG2,GSDME,SYK,PTPN6
1.793e-08	-17.84	DHR-2_Lobe_B	pfam domains	PF20422	11	4	17795	50	DOCK10,DOCK2,DOCK8,DOCK1
1.793e-08	-17.84	DHR-2_Lobe_A	pfam domains	PF06920	11	4	17795	50	DOCK2,DOCK10,DOCK1,DOCK8
1.793e-08	-17.84	DHR-2_Lobe_C	pfam domains	PF20421	11	4	17795	50	DOCK1,DOCK8,DOCK2,DOCK10
1.793e-08	-17.84	DOCK-C2	pfam domains	PF14429	11	4	17795	50	DOCK2,DOCK10,DOCK1,DOCK8
2.108e-08	-17.68	import into cell	biological process	GO:0098657	687	13	18204	49	DENND1B,DOCK1,SYK,VAV3,P2RY6,MYO1F,ARHGAP27,DOCK2,PRKCD,ELMO1,RIN3,PIK3CB,APOE
2.144e-08	-17.66	hemopoiesis	biological process	GO:0030097	688	13	18204	49	HIF1A,CSF1R,IL6R,PREX1,CD74,SEMA4A,DOCK2,SBNO2,SYK,DOCK10,PTPN6,PLCG2,SLC4A2
2.530e-08	-17.49	positive regulation of immune system process	biological process	GO:0002684	986	15	18204	49	PIK3CB,IL6R,CSF1R,PRKCD,CD74,DOCK8,FYB1,SKAP1,VAV3,PTPN6,SYK,GSDME,DENND1B,IRF5,PLCG2
2.717e-08	-17.42	GPVI-mediated activation cascade	REACTOME pathways	R-HSA-114604	54	6	10285	36	PTPN6,PLCG2,PIK3CB,PIK3R5,VAV3,SYK
3.009e-08	-17.32	regulation of body fluid levels	biological process	GO:0050878	356	10	18204	49	VAV3,WAS,HIF1A,APOE,PIK3CB,P2RY2,PLCG2,PTPN6,SYK,PRKCD
3.119e-08	-17.28	SH3 domain binding	molecular function	GO:0017124	122	7	18094	48	DOCK1,WAS,ELMO1,SKAP1,MICAL1,ARHGAP27,PTPN6
3.402e-08	-17.20	PH_domain	interpro domains	IPR001849	266	9	18521	50	PLCG2,DOCK10,IPCEF1,VAV3,SKAP1,PREX1,ELMO1,AKAP13,ARHGAP27
3.457e-08	-17.18	-	gene3d domains	1.20.58.740	11	4	14470	48	DOCK1,DOCK2,DOCK10,DOCK8
3.457e-08	-17.18	-	gene3d domains	1.25.40.410	11	4	14470	48	DOCK1,DOCK2,DOCK10,DOCK8
4.248e-08	-16.97	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	12	19454	50	PTPN6,FYB1,CSF1R,P2RY2,SKAP1,DOCK1,IL6R,SYK,HIF1A,PRKCD,MICAL1,WAS
4.411e-08	-16.94	positive regulation of molecular function	biological process	GO:0044093	1192	16	18204	49	DOCK10,SYK,PLCG2,PIK3R5,TBC1D8,P2RY6,CD74,PREX1,PRKCD,GMIP,ARHGAP27,DOCK8,HIF1A,APOE,IL6R,CSF1R
4.850e-08	-16.84	small GTPase binding	molecular function	GO:0031267	283	9	18094	48	MICAL1,DOCK2,AKAP13,WAS,RIN3,DOCK10,GIT2,DENND1B,DOCK1
4.877e-08	-16.84	Fc gamma R-mediated phagocytosis	KEGG pathways	hsa04666	90	7	7161	29	PIK3CB,PLCG2,SYK,PRKCD,VAV3,WAS,DOCK2
4.877e-08	-16.84	Fc gamma R-mediated phagocytosis	KEGG pathways	ko04666	90	7	7161	29	PLCG2,SYK,PIK3CB,PRKCD,VAV3,WAS,DOCK2
5.254e-08	-16.76	DOCKER	prosite domains	PS51651	11	4	12186	45	DOCK10,DOCK1,DOCK2,DOCK8
5.254e-08	-16.76	C2_DOCK	prosite domains	PS51650	11	4	12186	45	DOCK8,DOCK2,DOCK1,DOCK10
5.880e-08	-16.65	leukocyte activation involved in immune response	biological process	GO:0002366	201	8	18204	49	CD74,DOCK10,DOCK2,SEMA4A,SYK,PLCG2,SBNO2,IL6R
6.027e-08	-16.62	regulation of catalytic activity	biological process	GO:0050790	1395	17	18204	49	CSF1R,IL6R,RGS14,HIF1A,APOE,ARHGAP27,DOCK8,CD74,PREX1,PRKCD,GMIP,VAV3,PIK3R5,TBC1D8,P2RY6,DOCK10,SYK
6.848e-08	-16.50	cell activation involved in immune response	biological process	GO:0002263	205	8	18204	49	SYK,SEMA4A,DOCK10,DOCK2,CD74,PLCG2,IL6R,SBNO2
8.546e-08	-16.28	antigen receptor-mediated signaling pathway	biological process	GO:0050851	139	7	18204	49	FYB1,SKAP1,VAV3,DENND1B,PLCG2,SYK,PTPN6
9.423e-08	-16.18	SH3	prosite domains	PS50002	222	9	12186	45	ARHGAP27,MYO1F,PLCG2,VAV3,ARHGAP33,FYB1,DOCK2,SKAP1,DOCK1
1.081e-07	-16.04	positive regulation of response to stimulus	biological process	GO:0048584	2266	21	18204	49	PIK3CB,HIF1A,APOE,IL6R,CSF1R,PRKCD,CD74,AKAP13,P2RY6,NRK,PIK3R5,FYB1,WAS,VAV3,SKAP1,NEK6,PTPN6,SYK,GSDME,DENND1B,PLCG2
1.138e-07	-15.99	regulation of immune response	biological process	GO:0050776	944	14	18204	49	PLCG2,DENND1B,GSDME,SYK,PTPN6,SKAP1,VAV3,WAS,FYB1,RHBDF2,ADCY7,CD74,PRKCD,APOE
1.211e-07	-15.93	GTPase binding	molecular function	GO:0051020	315	9	18094	48	GIT2,DOCK10,RIN3,DENND1B,DOCK1,AKAP13,MICAL1,DOCK2,WAS
1.239e-07	-15.90	molecular function activator activity	molecular function	GO:0140677	1132	15	18094	48	HIF1A,PRKCD,RGS14,ARHGAP33,PREX1,GMIP,TBC1D8,DOCK1,RIN3,GIT2,APOE,DOCK2,ARHGAP27,VAV3,SEMA4A
1.387e-07	-15.79	regulation of cell motility	biological process	GO:2000145	1122	15	18204	49	APOE,HIF1A,PIK3CB,RIN3,CSF1R,IL6R,PREX1,CD74,SEMA4A,DOCK8,P2RY6,WAS,DOCK10,DOCK1,PLCG2
1.552e-07	-15.68	immune response-activating cell surface receptor signaling pathway	biological process	GO:0002429	228	8	18204	49	PRKCD,SYK,PTPN6,DENND1B,PLCG2,FYB1,SKAP1,VAV3
1.613e-07	-15.64	response to stimulus	biological process	GO:0050896	7803	39	18204	49	WAS,SKAP1,MICAL1,IRF5,DOCK10,PTPN6,ELMO1,RIN3,PIK3CB,RGS14,APOE,DOCK2,PRKCD,PREX1,FYB1,TBXAS1,VAV3,SBNO2,P2RY6,PIK3R5,DENND1B,IPCEF1,PLCG2,DOCK1,SYK,GSDME,IL6R,CSF1R,HIF1A,DOCK8,P2RY2,ARHGAP27,WDFY4,ARHGAP33,AKAP13,GMIP,SEMA4A,CD74,ADCY7
2.012e-07	-15.42	protein kinase binding	molecular function	GO:0019901	701	12	18094	48	PLCG2,SYK,IRF5,HIF1A,PTPN6,PRKCD,NEK6,SKAP1,WAS,ARHGAP33,RGS14,MICAL1
2.235e-07	-15.31	regulation of locomotion	biological process	GO:0040012	1164	15	18204	49	PREX1,CD74,SEMA4A,DOCK8,APOE,HIF1A,PIK3CB,RIN3,IL6R,CSF1R,DOCK10,DOCK1,PLCG2,P2RY6,WAS
2.432e-07	-15.23	immune response	biological process	GO:0006955	1349	16	18204	49	SEMA4A,PRKCD,DOCK2,CD74,IL6R,CSF1R,SYK,DOCK10,PTPN6,PLCG2,IRF5,PIK3R5,WAS,FYB1,SKAP1,SBNO2
2.741e-07	-15.11	regulation of signal transduction	biological process	GO:0009966	3114	24	18204	49	PIK3CB,APOE,RGS14,PRKCD,DOCK2,PREX1,NRK,PTPN6,HIF1A,CSF1R,GMIP,RHBDF2,CD74,DOCK8,AKAP13,ARHGAP27,P2RY6,PIK3R5,VAV3,SYK,NEK6,GIT2,GSDME,PLCG2
3.616e-07	-14.83	C2_domain_sf	interpro domains	IPR035892	171	7	18521	50	PLCG2,DOCK2,DOCK8,DOCK10,DOCK1,PRKCD,PIK3CB
3.716e-07	-14.81	positive regulation of cell migration	biological process	GO:0030335	592	11	18204	49	DOCK1,SEMA4A,CD74,PREX1,DOCK8,PLCG2,P2RY6,PIK3CB,HIF1A,CSF1R,IL6R
3.986e-07	-14.74	small GTPase-mediated signal transduction	biological process	GO:0007264	258	8	18204	49	DOCK10,DOCK2,DOCK1,ARHGAP33,DOCK8,VAV3,ELMO1,WAS
4.058e-07	-14.72	Chemokine signaling pathway	KEGG pathways	ko04062	182	8	7161	29	ELMO1,PRKCD,VAV3,WAS,DOCK2,PREX1,ADCY7,PIK3CB
4.058e-07	-14.72	Chemokine signaling pathway	KEGG pathways	hsa04062	182	8	7161	29	ELMO1,WAS,VAV3,PRKCD,DOCK2,PREX1,ADCY7,PIK3CB
4.083e-07	-14.71	positive regulation of intracellular signal transduction	biological process	GO:1902533	1048	14	18204	49	NEK6,PTPN6,SYK,GSDME,PLCG2,NRK,P2RY6,PIK3R5,VAV3,CD74,AKAP13,PIK3CB,APOE,CSF1R
4.479e-07	-14.62	immune response-regulating cell surface receptor signaling pathway	biological process	GO:0002768	262	8	18204	49	FYB1,SKAP1,VAV3,PRKCD,SYK,PTPN6,DENND1B,PLCG2
4.696e-07	-14.57	mononuclear cell differentiation	biological process	GO:1903131	364	9	18204	49	PLCG2,DOCK2,DOCK10,SEMA4A,SYK,CD74,PREX1,CSF1R,IL6R
4.740e-07	-14.56	regulation of cell migration	biological process	GO:0030334	1061	14	18204	49	RIN3,PIK3CB,APOE,HIF1A,IL6R,CSF1R,SEMA4A,CD74,PREX1,DOCK8,P2RY6,DOCK10,DOCK1,PLCG2
5.781e-07	-14.36	positive regulation of cell motility	biological process	GO:2000147	619	11	18204	49	PLCG2,DOCK1,P2RY6,DOCK8,SEMA4A,PREX1,CD74,IL6R,CSF1R,PIK3CB,HIF1A
6.301e-07	-14.28	kinase binding	molecular function	GO:0019900	780	12	18094	48	IRF5,HIF1A,NEK6,PTPN6,PRKCD,SKAP1,WAS,ARHGAP33,RGS14,MICAL1,PLCG2,SYK
7.207e-07	-14.14	positive regulation of locomotion	biological process	GO:0040017	633	11	18204	49	CSF1R,IL6R,PIK3CB,HIF1A,DOCK8,SEMA4A,PREX1,CD74,P2RY6,PLCG2,DOCK1
7.517e-07	-14.10	C2 domain	gene3d domains	2.60.40.150	156	7	14470	48	DOCK10,PIK3CB,DOCK1,DOCK8,PLCG2,DOCK2,PRKCD
7.787e-07	-14.07	vesicle-mediated transport	biological process	GO:0016192	1283	15	18204	49	GIT2,SYK,DOCK1,DENND1B,P2RY6,VAV3,WAS,PRKCD,DOCK2,ARHGAP27,MYO1F,APOE,PIK3CB,RIN3,ELMO1
8.343e-07	-14.00	Hemostasis	REACTOME pathways	R-HSA-109582	632	12	10285	36	CD74,PLCG2,PRKCD,PIK3CB,PTPN6,DOCK10,PIK3R5,DOCK2,SYK,VAV3,DOCK1,DOCK8
8.355e-07	-14.00	response to external stimulus	biological process	GO:0009605	1882	18	18204	49	SBNO2,VAV3,WAS,GSDME,PTPN6,SYK,PLCG2,IRF5,HIF1A,PIK3CB,IL6R,CSF1R,CD74,PREX1,DOCK2,SEMA4A,PRKCD,WDFY4
8.489e-07	-13.98	membrane	cellular component	GO:0016020	9220	41	19108	50	DOCK8,ADCY7,DOCK1,IPCEF1,EHBP1L1,CARMIL3,PTPN6,WAS,PIK3R5,RHBDF2,CD74,DOCK2,DOCK10,TBC1D8,P2RY6,CSF1R,MICAL1,GLIPR1,SEMA4A,ELMO1,TBXAS1,GMIP,PREX1,FYB1,IL6R,SLC4A2,RGS14,P2RY2,VAV3,AKAP13,APOE,ARHGAP33,PARVG,SYK,PLCG2,GSDME,MYO1F,SKAP1,PIK3CB,PRKCD,ARHGAP27
9.639e-07	-13.85	lymphocyte differentiation	biological process	GO:0030098	290	8	18204	49	PREX1,CD74,SEMA4A,SYK,DOCK10,DOCK2,PLCG2,IL6R
1.029e-06	-13.79	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	13	19454	50	SLC4A2,PREX1,ARHGAP27,WAS,EHBP1L1,PRKCD,GMIP,ARHGAP33,VAV3,DOCK8,DOCK1,GIT2,DOCK2
1.074e-06	-13.74	SH3	smart domains	SM00326	202	8	9717	39	PLCG2,VAV3,MYO1F,ARHGAP33,DOCK1,SKAP1,FYB1,DOCK2
1.075e-06	-13.74	CRKL (CRK like proto-oncogene, adaptor protein)	protein interactions	1399	211	7	19454	50	WAS,DOCK1,ELMO1,SYK,DOCK2,RIN3,PIK3CB
1.306e-06	-13.55	immune response-activating signaling pathway	biological process	GO:0002757	302	8	18204	49	PTPN6,SYK,PRKCD,PLCG2,DENND1B,VAV3,SKAP1,FYB1
1.400e-06	-13.48	positive regulation of chemokine production	biological process	GO:0032722	72	5	18204	49	HIF1A,CD74,SYK,IL6R,CSF1R
1.531e-06	-13.39	cellular response to chemical stimulus	biological process	GO:0070887	2411	20	18204	49	IRF5,PLCG2,IPCEF1,SYK,PTPN6,GSDME,WAS,VAV3,SBNO2,P2RY6,DOCK8,P2RY2,PRKCD,PREX1,ADCY7,CD74,CSF1R,IL6R,APOE,HIF1A
1.789e-06	-13.23	Role of phospholipids in phagocytosis	REACTOME pathways	R-HSA-2029485	26	4	10285	36	PRKCD,PIK3CB,PLCG2,SYK
1.910e-06	-13.17	regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050730	220	7	18204	49	IL6R,CSF1R,PLCG2,PTPN6,SYK,PRKCD,CD74
1.920e-06	-13.16	cell surface receptor signaling pathway	biological process	GO:0007166	1992	18	18204	49	IL6R,CSF1R,RGS14,PIK3CB,P2RY2,CD74,SEMA4A,PRKCD,SKAP1,VAV3,FYB1,P2RY6,PLCG2,IRF5,DENND1B,PTPN6,DOCK1,SYK
2.033e-06	-13.11	Regulation of actin dynamics for phagocytic cup formation	REACTOME pathways	R-HSA-2029482	61	5	10285	36	DOCK1,ELMO1,SYK,VAV3,WAS
2.110e-06	-13.07	regulation of molecular function	biological process	GO:0065009	2005	18	18204	49	VAV3,TBC1D8,PIK3R5,P2RY6,PLCG2,SYK,DOCK10,CSF1R,IL6R,APOE,HIF1A,RGS14,ARHGAP27,DOCK8,PREX1,CD74,PRKCD,GMIP
2.126e-06	-13.06	response to chemical	biological process	GO:0042221	3743	25	18204	49	IPCEF1,PLCG2,GSDME,SYK,VAV3,SBNO2,TBXAS1,P2RY6,ARHGAP33,P2RY2,DOCK8,ADCY7,CD74,SEMA4A,IL6R,CSF1R,HIF1A,IRF5,PTPN6,WAS,PREX1,PRKCD,DOCK2,APOE,PIK3CB
2.136e-06	-13.06	positive regulation of cell communication	biological process	GO:0010647	1792	17	18204	49	CSF1R,PIK3CB,HIF1A,APOE,RGS14,AKAP13,PRKCD,CD74,VAV3,NRK,P2RY6,PIK3R5,PLCG2,SYK,NEK6,PTPN6,GSDME
2.169e-06	-13.04	positive regulation of signaling	biological process	GO:0023056	1794	17	18204	49	PTPN6,NEK6,SYK,GSDME,PLCG2,P2RY6,NRK,PIK3R5,VAV3,PRKCD,CD74,AKAP13,PIK3CB,RGS14,APOE,HIF1A,CSF1R
2.257e-06	-13.00	positive regulation of signal transduction	biological process	GO:0009967	1593	16	18204	49	CD74,PRKCD,AKAP13,HIF1A,APOE,PIK3CB,CSF1R,GSDME,NEK6,PTPN6,SYK,PLCG2,PIK3R5,P2RY6,NRK,VAV3
2.518e-06	-12.89	positive regulation of cytokine production involved in immune response	biological process	GO:0002720	81	5	18204	49	DENND1B,IRF5,PLCG2,SYK,CD74
2.782e-06	-12.79	PH_DOMAIN	prosite domains	PS50003	246	8	12186	45	PREX1,DOCK10,SKAP1,AKAP13,VAV3,ARHGAP27,IPCEF1,PLCG2
2.815e-06	-12.78	SHC1 (SHC adaptor protein 1)	protein interactions	6464	350	8	19454	50	PLCG2,CSF1R,PTPN6,RIN3,PRKCD,HIF1A,SYK,VAV3
2.971e-06	-12.73	regulation of signaling	biological process	GO:0023051	3534	24	18204	49	NRK,PTPN6,PIK3CB,RGS14,APOE,DOCK2,PRKCD,PREX1,P2RY6,PIK3R5,VAV3,NEK6,SYK,GSDME,GIT2,PLCG2,HIF1A,CSF1R,GMIP,CD74,RHBDF2,DOCK8,ARHGAP27,AKAP13
3.049e-06	-12.70	cellular response to cytokine stimulus	biological process	GO:0071345	734	11	18204	49	HIF1A,CSF1R,IL6R,CD74,DOCK8,WAS,SBNO2,SYK,PTPN6,GSDME,IRF5
3.081e-06	-12.69	regulation of cell communication	biological process	GO:0010646	3541	24	18204	49	CSF1R,APOE,HIF1A,RGS14,PIK3CB,AKAP13,ARHGAP27,DOCK8,RHBDF2,PREX1,CD74,GMIP,PRKCD,DOCK2,VAV3,PIK3R5,NRK,P2RY6,PLCG2,GIT2,GSDME,SYK,PTPN6,NEK6
3.125e-06	-12.68	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	11	19454	50	RIN3,PIK3CB,CSF1R,PTPN6,VAV3,WAS,MICAL1,DOCK1,SKAP1,IRF5,SYK
3.296e-06	-12.62	positive regulation of biological process	biological process	GO:0048518	6326	33	18204	49	PRKCD,DOCK2,PREX1,PIK3CB,APOE,RGS14,IRF5,PTPN6,WAS,SKAP1,NRK,TBC1D8,DOCK8,AKAP13,P2RY2,SEMA4A,CD74,CSF1R,IL6R,HIF1A,DENND1B,PLCG2,SLC4A2,SYK,NEK6,DOCK1,GSDME,TBXAS1,FYB1,VAV3,SBNO2,P2RY6,PIK3R5
3.515e-06	-12.56	chemotaxis	biological process	GO:0006935	345	8	18204	49	IL6R,VAV3,PIK3CB,SYK,PRKCD,SEMA4A,DOCK2,PREX1
3.574e-06	-12.54	myeloid leukocyte activation	biological process	GO:0002274	155	6	18204	49	PLCG2,SBNO2,PRKCD,SYK,DOCK2,PREX1
3.615e-06	-12.53	positive regulation of hydrolase activity	biological process	GO:0051345	466	9	18204	49	PREX1,GMIP,PRKCD,SYK,DOCK10,ARHGAP27,DOCK8,TBC1D8,P2RY6
3.669e-06	-12.52	taxis	biological process	GO:0042330	347	8	18204	49	PREX1,DOCK2,PRKCD,SYK,SEMA4A,PIK3CB,VAV3,IL6R
3.706e-06	-12.51	cytosol	cellular component	GO:0005829	5475	30	19108	50	PLCG2,SYK,ARHGAP33,AKAP13,VAV3,PRKCD,ARHGAP27,PIK3CB,SKAP1,MYO1F,GSDME,FYB1,PREX1,GMIP,TBXAS1,ELMO1,IRF5,RIN3,PIK3R5,PTPN6,WAS,MICAL1,DOCK10,HIF1A,DOCK2,DENND1B,NRK,DOCK8,NEK6,DOCK1
4.081e-06	-12.41	positive regulation of MAPK cascade	biological process	GO:0043410	473	9	18204	49	CSF1R,P2RY6,NRK,APOE,PIK3R5,PLCG2,SYK,CD74,GSDME
4.141e-06	-12.39	phagocytosis	biological process	GO:0006909	159	6	18204	49	DOCK1,PRKCD,SYK,VAV3,ELMO1,P2RY6
4.259e-06	-12.37	cell migration	biological process	GO:0016477	921	12	18204	49	IL6R,HIF1A,PIK3CB,DOCK8,PREX1,PRKCD,SEMA4A,DOCK2,VAV3,SYK,DOCK1,CARMIL3
4.425e-06	-12.33	BLNK (B cell linker)	protein interactions	29760	43	4	19454	50	PTPN6,SYK,PLCG2,VAV3
4.502e-06	-12.31	transport	biological process	GO:0006810	3615	24	18204	49	MYO1F,ARHGAP33,ARHGAP27,PRKCD,DOCK2,RHBDF2,CD74,ELMO1,PIK3CB,RIN3,HIF1A,APOE,RGS14,DENND1B,PLCG2,IPCEF1,SLC4A2,SYK,DOCK1,GIT2,GSDME,WAS,VAV3,P2RY6
4.596e-06	-12.29	cell motility	biological process	GO:0048870	1101	13	18204	49	VAV3,SYK,CARMIL3,DOCK1,IL6R,ELMO1,PIK3CB,HIF1A,DOCK8,PRKCD,SEMA4A,DOCK2,PREX1
4.918e-06	-12.22	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	16	18204	49	CD74,SEMA4A,P2RY2,DOCK8,RGS14,APOE,HIF1A,IL6R,CSF1R,PTPN6,SYK,IRF5,PLCG2,DENND1B,VAV3,TBXAS1
4.927e-06	-12.22	CBLB (Cbl proto-oncogene B)	protein interactions	868	97	5	19454	50	VAV3,WAS,PLCG2,FYB1,SYK
5.322e-06	-12.14	SH3BP2 (SH3 domain binding protein 2)	protein interactions	6452	45	4	19454	50	PLCG2,SYK,VAV3,MYO1F
5.541e-06	-12.10	locomotion	biological process	GO:0040011	367	8	18204	49	PREX1,PRKCD,SYK,SEMA4A,DOCK2,IL6R,VAV3,PIK3CB
5.653e-06	-12.08	immune response-regulating signaling pathway	biological process	GO:0002764	368	8	18204	49	FYB1,SKAP1,VAV3,PTPN6,SYK,PRKCD,DENND1B,PLCG2
5.653e-06	-12.08	activation of immune response	biological process	GO:0002253	368	8	18204	49	PLCG2,DENND1B,SYK,PRKCD,PTPN6,VAV3,SKAP1,FYB1
5.700e-06	-12.08	MS4A2 (membrane spanning 4-domains A2)	protein interactions	2206	14	3	19454	50	PRKCD,PTPN6,SYK
5.810e-06	-12.06	B cell receptor signaling pathway	biological process	GO:0050853	44	4	18204	49	VAV3,PLCG2,PTPN6,SYK
5.946e-06	-12.03	cellular response to organic substance	biological process	GO:0071310	1716	16	18204	49	SBNO2,WAS,P2RY6,PLCG2,IRF5,GSDME,SYK,PTPN6,IL6R,CSF1R,HIF1A,P2RY2,DOCK8,ADCY7,CD74,PRKCD
6.397e-06	-11.96	positive regulation of immune response	biological process	GO:0050778	640	10	18204	49	VAV3,SKAP1,FYB1,PLCG2,DENND1B,CD74,GSDME,SYK,PRKCD,PTPN6
6.871e-06	-11.89	PH	smart domains	SM00233	259	8	9717	39	DOCK10,ARHGAP27,IPCEF1,VAV3,PLCG2,PREX1,AKAP13,SKAP1
7.429e-06	-11.81	blood coagulation	biological process	GO:0007596	176	6	18204	49	WAS,PLCG2,VAV3,PIK3CB,SYK,PTPN6
7.476e-06	-11.80	platelet activation	biological process	GO:0030168	101	5	18204	49	PLCG2,VAV3,PIK3CB,SYK,PTPN6
7.544e-06	-11.79	regulation of cell adhesion	biological process	GO:0030155	807	11	18204	49	VAV3,SKAP1,PIK3CB,DOCK8,SLC4A2,DOCK1,PTPN6,SYK,PRKCD,CD74,PREX1
7.588e-06	-11.79	T cell selection	biological process	GO:0045058	47	4	18204	49	IL6R,SYK,DOCK2,CD74
7.645e-06	-11.78	B cell receptor signaling pathway	KEGG pathways	hsa04662	70	5	7161	29	PIK3CB,VAV3,SYK,PTPN6,PLCG2
7.645e-06	-11.78	B cell receptor signaling pathway	KEGG pathways	ko04662	70	5	7161	29	PTPN6,SYK,PLCG2,PIK3CB,VAV3
7.673e-06	-11.78	regulation of phosphate metabolic process	biological process	GO:0019220	1154	13	18204	49	HIF1A,APOE,RGS14,CSF1R,IL6R,PRKCD,CD74,P2RY6,PIK3R5,SYK,PTPN6,PLCG2,MICAL1
7.746e-06	-11.77	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	13	18204	49	MICAL1,PLCG2,PTPN6,SYK,PIK3R5,P2RY6,CD74,PRKCD,CSF1R,IL6R,RGS14,APOE,HIF1A
7.811e-06	-11.76	Platelet activation	KEGG pathways	hsa04611	123	6	7161	29	SYK,TBXAS1,PLCG2,PIK3CB,PIK3R5,ADCY7
7.845e-06	-11.76	alpha-beta T cell activation	biological process	GO:0046631	102	5	18204	49	WDFY4,IL6R,DOCK2,SYK,SEMA4A
7.925e-06	-11.75	coagulation	biological process	GO:0050817	178	6	18204	49	WAS,VAV3,PIK3CB,PLCG2,PTPN6,SYK
8.627e-06	-11.66	regulation of chemokine production	biological process	GO:0032642	104	5	18204	49	SYK,HIF1A,CD74,IL6R,CSF1R
8.629e-06	-11.66	Rho GTPase cycle	REACTOME pathways	R-HSA-194840	142	6	10285	36	ARHGAP33,AKAP13,PREX1,GMIP,ARHGAP27,VAV3
8.916e-06	-11.63	regulation of GTPase activity	biological process	GO:0043087	278	7	18204	49	TBC1D8,VAV3,PREX1,DOCK10,GMIP,ARHGAP27,DOCK8
8.984e-06	-11.62	regulation of cellular component organization	biological process	GO:0051128	2455	19	18204	49	RIN3,PIK3CB,HIF1A,APOE,CSF1R,DOCK2,SEMA4A,PRKCD,PREX1,ARHGAP33,AKAP13,TBC1D8,WAS,SKAP1,CARMIL3,NEK6,SYK,SLC4A2,PLCG2
9.000e-06	-11.62	hemostasis	biological process	GO:0007599	182	6	18204	49	PIK3CB,SYK,PTPN6,WAS,PLCG2,VAV3
9.000e-06	-11.62	T cell differentiation	biological process	GO:0030217	182	6	18204	49	IL6R,CD74,PREX1,DOCK2,SEMA4A,SYK
9.125e-06	-11.60	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	5	19454	50	VAV3,CSF1R,PLCG2,SYK,PTPN6
9.217e-06	-11.59	T cell receptor complex	cellular component	GO:0042101	16	3	19108	50	PTPN6,SYK,SKAP1
9.652e-06	-11.55	FYN (FYN proto-oncogene, Src family tyrosine kinase)	protein interactions	2534	414	8	19454	50	FYB1,PLCG2,CSF1R,WAS,SYK,ARHGAP33,PRKCD,SKAP1
9.913e-06	-11.52	T cell receptor signaling pathway	biological process	GO:0050852	107	5	18204	49	PTPN6,FYB1,DENND1B,SKAP1,PLCG2
1.030e-05	-11.48	response to cytokine	biological process	GO:0034097	834	11	18204	49	SYK,PTPN6,GSDME,IRF5,WAS,SBNO2,CD74,DOCK8,HIF1A,IL6R,CSF1R
1.105e-05	-11.41	SH2	interpro domains	IPR000980	109	5	18521	50	PLCG2,RIN3,VAV3,PTPN6,SYK
1.275e-05	-11.27	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	31	16828	46	P2RY2,PARVG,P2RY6,RIN3,TBC1D8,RHBDF2,EHBP1L1,AKAP13,IRF5,ARHGAP27,PREX1,IPCEF1,DOCK8,DOCK10,GMIP,SLC4A2,RGS14,PRKCD,HIF1A,DOCK1,CSF1R,ADCY7,PIK3CB,MYO1F,DOCK2,WAS,ELMO1,PLCG2,MICAL1,TBXAS1,VAV3
1.311e-05	-11.24	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	7	18204	49	SYK,PTPN6,CD74,P2RY6,APOE,RGS14,CSF1R
1.316e-05	-11.24	SH2_dom_sf	interpro domains	IPR036860	113	5	18521	50	VAV3,RIN3,PLCG2,SYK,PTPN6
1.428e-05	-11.16	Fc receptor signaling pathway	biological process	GO:0038093	55	4	18204	49	VAV3,PLCG2,PRKCD,SYK
1.661e-05	-11.01	establishment of localization	biological process	GO:0051234	3887	24	18204	49	VAV3,WAS,P2RY6,SLC4A2,PLCG2,IPCEF1,DENND1B,GSDME,GIT2,DOCK1,SYK,ELMO1,RGS14,APOE,HIF1A,RIN3,PIK3CB,ARHGAP27,ARHGAP33,MYO1F,CD74,RHBDF2,DOCK2,PRKCD
1.686e-05	-10.99	localization	biological process	GO:0051179	4474	26	18204	49	ARHGAP33,ARHGAP27,RHBDF2,CD74,HIF1A,IPCEF1,PLCG2,SLC4A2,DENND1B,GIT2,GSDME,SYK,DOCK1,VAV3,FYB1,P2RY6,MYO1F,PRKCD,DOCK2,ELMO1,APOE,RGS14,PIK3CB,RIN3,SKAP1,WAS
1.723e-05	-10.97	macrophage activation involved in immune response	biological process	GO:0002281	19	3	18204	49	SBNO2,PLCG2,SYK
1.731e-05	-10.96	regulation of cytokine production involved in immune response	biological process	GO:0002718	120	5	18204	49	PLCG2,IRF5,DENND1B,CD74,SYK
1.792e-05	-10.93	Signal Transduction	REACTOME pathways	R-HSA-162582	2547	21	10285	36	ARHGAP27,GMIP,WAS,PREX1,APOE,ELMO1,IL6R,RGS14,ADCY7,P2RY2,DOCK1,SYK,VAV3,PIK3R5,P2RY6,PTPN6,AKAP13,ARHGAP33,HIF1A,PIK3CB,PRKCD
1.909e-05	-10.87	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	8	19454	50	WAS,IL6R,SKAP1,PRKCD,SYK,RIN3,PLCG2,PTPN6
1.918e-05	-10.86	regulation of hydrolase activity	biological process	GO:0051336	726	10	18204	49	DOCK10,SYK,PRKCD,GMIP,PREX1,DOCK8,ARHGAP27,P2RY6,TBC1D8,VAV3
2.023e-05	-10.81	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	GO:0038096	20	3	18204	49	VAV3,SYK,PRKCD
2.023e-05	-10.81	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological process	GO:0002433	20	3	18204	49	VAV3,PRKCD,SYK
2.064e-05	-10.79	G protein-coupled UTP receptor activity	molecular function	GO:0045030	3	2	18094	48	P2RY2,P2RY6
2.084e-05	-10.78	positive regulation of GTPase activity	biological process	GO:0043547	211	6	18204	49	TBC1D8,DOCK10,GMIP,PREX1,DOCK8,ARHGAP27
2.088e-05	-10.78	regulation of multicellular organismal process	biological process	GO:0051239	3113	21	18204	49	CSF1R,IL6R,RGS14,HIF1A,APOE,PIK3CB,P2RY2,DOCK8,CD74,ADCY7,SEMA4A,PRKCD,VAV3,TBXAS1,SLC4A2,IRF5,PLCG2,DENND1B,PTPN6,DOCK1,SYK
2.259e-05	-10.70	wound healing	biological process	GO:0042060	321	7	18204	49	PIK3CB,HIF1A,WAS,VAV3,PTPN6,SYK,PLCG2
2.475e-05	-10.61	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	24	16828	46	GIT2,DOCK2,PIK3CB,MYO1F,CSF1R,DOCK1,PIK3R5,HIF1A,SLC4A2,VAV3,TBXAS1,PLCG2,PTPN6,ELMO1,WAS,IRF5,AKAP13,RHBDF2,EHBP1L1,RIN3,GMIP,DOCK8,IPCEF1,PREX1
2.486e-05	-10.60	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	24	16828	46	RIN3,RHBDF2,EHBP1L1,AKAP13,IRF5,PREX1,IPCEF1,DOCK8,GMIP,SLC4A2,HIF1A,PIK3R5,DOCK1,CSF1R,PIK3CB,MYO1F,GIT2,DOCK2,WAS,ELMO1,PTPN6,PLCG2,TBXAS1,VAV3
2.496e-05	-10.60	regulation of protein phosphorylation	biological process	GO:0001932	917	11	18204	49	CD74,PRKCD,IL6R,CSF1R,RGS14,APOE,MICAL1,PLCG2,PTPN6,SYK,PIK3R5
2.557e-05	-10.57	SH3_2	pfam domains	PF07653	61	4	17795	50	DOCK2,VAV3,FYB1,ARHGAP33
2.688e-05	-10.52	Regulation of RAC1 activity	Pathway Interaction DB	rac1_reg_pathway	39	5	2226	22	DOCK2,ELMO1,DOCK1,VAV3,PREX1
2.723e-05	-10.51	Fc receptor mediated stimulatory signaling pathway	biological process	GO:0002431	22	3	18204	49	VAV3,PRKCD,SYK
2.723e-05	-10.51	positive regulation of cell adhesion mediated by integrin	biological process	GO:0033630	22	3	18204	49	SYK,PTPN6,SKAP1
2.827e-05	-10.47	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	33	16828	46	GIT2,DOCK2,PIK3CB,MYO1F,CSF1R,DOCK1,SLC4A2,PRKCD,RGS14,TBXAS1,VAV3,MICAL1,PLCG2,WAS,PTPN6,ELMO1,AKAP13,EHBP1L1,RHBDF2,IRF5,TBC1D8,NEK6,RIN3,PARVG,P2RY2,SYK,ARHGAP33,DOCK10,GMIP,WDFY4,SBNO2,DENND1B,PREX1
2.891e-05	-10.45	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	24	16828	46	IRF5,EHBP1L1,RHBDF2,AKAP13,RIN3,GMIP,DOCK8,IPCEF1,PREX1,MYO1F,PIK3CB,DOCK2,GIT2,CSF1R,DOCK1,PIK3R5,HIF1A,SLC4A2,VAV3,TBXAS1,PLCG2,PTPN6,ELMO1,WAS
2.953e-05	-10.43	myeloid cell activation involved in immune response	biological process	GO:0002275	66	4	18204	49	SBNO2,PLCG2,DOCK2,SYK
2.994e-05	-10.42	PE/DAG-bd	interpro domains	IPR002219	66	4	18521	50	VAV3,PRKCD,GMIP,AKAP13
3.056e-05	-10.40	positive regulation of production of molecular mediator of immune response	biological process	GO:0002702	135	5	18204	49	DENND1B,PLCG2,IRF5,SYK,CD74
3.194e-05	-10.35	SH2 domain	gene3d domains	3.30.505.10	111	5	14470	48	PTPN6,RIN3,PLCG2,VAV3,SYK
3.279e-05	-10.33	lymphocyte activation involved in immune response	biological process	GO:0002285	137	5	18204	49	SEMA4A,DOCK10,CD74,PLCG2,IL6R
3.387e-05	-10.29	regulation of actin cytoskeleton organization	biological process	GO:0032956	342	7	18204	49	CSF1R,WAS,SLC4A2,AKAP13,PREX1,CARMIL3,PRKCD
3.611e-05	-10.23	biological process involved in interspecies interaction between organisms	biological process	GO:0044419	1540	14	18204	49	SBNO2,WAS,GSDME,PTPN6,SYK,IRF5,PLCG2,HIF1A,APOE,CSF1R,IL6R,CD74,PRKCD,WDFY4
3.774e-05	-10.18	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	5	7161	29	PRKCD,ADCY7,P2RY2,PIK3CB,PLCG2
3.774e-05	-10.18	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	5	7161	29	P2RY2,PIK3CB,PRKCD,ADCY7,PLCG2
4.043e-05	-10.12	Fc-epsilon receptor signaling pathway	biological process	GO:0038095	25	3	18204	49	SYK,VAV3,PLCG2
4.077e-05	-10.11	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	34	16828	46	DOCK8,DENND1B,GMIP,ARHGAP33,DOCK10,IPCEF1,PREX1,ARHGAP27,TBC1D8,IRF5,AKAP13,RHBDF2,EHBP1L1,P2RY6,PARVG,P2RY2,RIN3,MICAL1,VAV3,TBXAS1,PTPN6,ELMO1,WAS,PLCG2,CSF1R,DOCK2,MYO1F,PIK3CB,ADCY7,PRKCD,RGS14,SLC4A2,DOCK1,HIF1A
4.121e-05	-10.10	G protein-coupled pyrimidinergic nucleotide receptor activity	molecular function	GO:0071553	4	2	18094	48	P2RY2,P2RY6
4.197e-05	-10.08	positive regulation of cell adhesion	biological process	GO:0045785	486	8	18204	49	DOCK1,PTPN6,SYK,CD74,PREX1,DOCK8,SKAP1,VAV3
4.390e-05	-10.03	SH2	prosite domains	PS50001	107	5	12186	45	VAV3,PTPN6,SYK,PLCG2,RIN3
4.505e-05	-10.01	response to other organism	biological process	GO:0051707	1363	13	18204	49	HIF1A,CSF1R,IL6R,CD74,PRKCD,WDFY4,SBNO2,WAS,GSDME,PTPN6,SYK,PLCG2,IRF5
4.560e-05	-10.00	protein domain specific binding	molecular function	GO:0019904	651	9	18094	48	HIF1A,DOCK1,PTPN6,SKAP1,ELMO1,WAS,SYK,ARHGAP27,MICAL1
4.562e-05	-10.00	Platelet activation, signaling and aggregation	REACTOME pathways	R-HSA-76002	282	7	10285	36	PRKCD,PIK3CB,PTPN6,PLCG2,PIK3R5,SYK,VAV3
4.609e-05	-9.98	response to external biotic stimulus	biological process	GO:0043207	1366	13	18204	49	SBNO2,WAS,IRF5,PLCG2,GSDME,PTPN6,SYK,CSF1R,IL6R,HIF1A,WDFY4,CD74,PRKCD
4.986e-05	-9.91	regulation of anatomical structure size	biological process	GO:0090066	498	8	18204	49	P2RY2,PRKCD,PREX1,TBXAS1,WAS,VAV3,RIN3,APOE
5.003e-05	-9.90	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	6	19454	50	VAV3,RIN3,WAS,PTPN6,SYK,PLCG2
5.129e-05	-9.88	positive regulation of cytokine production	biological process	GO:0001819	500	8	18204	49	HIF1A,CSF1R,IL6R,SYK,CD74,DENND1B,IRF5,PLCG2
5.227e-05	-9.86	regulation of phosphorylation	biological process	GO:0042325	994	11	18204	49	MICAL1,PLCG2,PTPN6,PRKCD,SYK,CD74,IL6R,CSF1R,PIK3R5,RGS14,APOE
5.249e-05	-9.85	SH2	smart domains	SM00252	103	5	9717	39	VAV3,PLCG2,SYK,PTPN6,RIN3
5.439e-05	-9.82	positive regulation of cellular process	biological process	GO:0048522	5719	29	18204	49	RGS14,APOE,PIK3CB,PREX1,DOCK2,PRKCD,SKAP1,WAS,TBC1D8,NRK,IRF5,PTPN6,CSF1R,IL6R,HIF1A,AKAP13,DOCK8,CD74,SEMA4A,VAV3,SBNO2,PIK3R5,P2RY6,PLCG2,DENND1B,GSDME,NEK6,DOCK1,SYK
5.559e-05	-9.80	leukocyte proliferation	biological process	GO:0070661	153	5	18204	49	CSF1R,DOCK8,PTPN6,DOCK2,PRKCD
5.851e-05	-9.75	-	gene3d domains	3.30.60.20	64	4	14470	48	AKAP13,PRKCD,VAV3,GMIP
5.952e-05	-9.73	ZF_DAG_PE_1	prosite domains	PS00479	58	4	12186	45	VAV3,AKAP13,PRKCD,GMIP
6.249e-05	-9.68	PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)	protein interactions	5295	394	7	19454	50	PLCG2,CSF1R,PTPN6,PIK3CB,SYK,WAS,VAV3
6.307e-05	-9.67	response to biotic stimulus	biological process	GO:0009607	1408	13	18204	49	CSF1R,IL6R,HIF1A,WDFY4,CD74,PRKCD,SBNO2,WAS,IRF5,PLCG2,GSDME,SYK,PTPN6
6.354e-05	-9.66	regulation of transport	biological process	GO:0051049	1621	14	18204	49	MICAL1,PLCG2,PTPN6,SYK,P2RY6,P2RY2,CD74,RHBDF2,DOCK2,PRKCD,HIF1A,APOE,RIN3,PIK3CB
6.552e-05	-9.63	T-Cell antigen Receptor (TCR) Signaling Pathway	WikiPathways	WP69	91	5	5310	26	FYB1,PRKCD,WAS,VAV3,SKAP1
6.709e-05	-9.61	CH_dom	interpro domains	IPR001715	81	4	18521	50	VAV3,EHBP1L1,MICAL1,PARVG
6.840e-05	-9.59	positive regulation of immune effector process	biological process	GO:0002699	261	6	18204	49	IRF5,PLCG2,DENND1B,CD74,SYK,PTPN6
7.039e-05	-9.56	CH_dom_sf	interpro domains	IPR036872	82	4	18521	50	MICAL1,EHBP1L1,PARVG,VAV3
7.044e-05	-9.56	regulation of actin filament-based process	biological process	GO:0032970	384	7	18204	49	WAS,CSF1R,PRKCD,CARMIL3,PREX1,AKAP13,SLC4A2
7.081e-05	-9.56	positive regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050731	161	5	18204	49	PLCG2,CSF1R,IL6R,CD74,SYK
7.106e-05	-9.55	DOCK_N	interpro domains	IPR032376	5	2	18521	50	DOCK1,DOCK2
7.106e-05	-9.55	DOCK_N_sub1	interpro domains	IPR042455	5	2	18521	50	DOCK1,DOCK2
7.217e-05	-9.54	Immune System	REACTOME pathways	R-HSA-168256	2101	18	10285	36	CSF1R,WAS,ADCY7,CD74,IL6R,PLCG2,IRF5,ELMO1,FYB1,GLIPR1,DOCK2,SYK,VAV3,DOCK1,PRKCD,PIK3CB,HIF1A,PTPN6
7.316e-05	-9.52	CDC42 (cell division cycle 42)	protein interactions	998	1280	12	19454	50	DOCK8,GIT2,PLCG2,NEK6,TBC1D8,GMIP,WAS,EHBP1L1,ARHGAP27,PREX1,SLC4A2,DOCK10
7.696e-05	-9.47	DOCK_N	pfam domains	PF16172	5	2	17795	50	DOCK1,DOCK2
7.763e-05	-9.46	regulation of immune effector process	biological process	GO:0002697	390	7	18204	49	WAS,DENND1B,IRF5,PLCG2,SYK,PTPN6,CD74
7.813e-05	-9.46	neutrophil activation	biological process	GO:0042119	31	3	18204	49	SYK,PRKCD,PREX1
8.244e-05	-9.40	ZF_DAG_PE_2	prosite domains	PS50081	63	4	12186	45	VAV3,AKAP13,GMIP,PRKCD
8.267e-05	-9.40	NME2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	4831	174	5	19454	50	PREX1,AKAP13,GIT2,DOCK8,PLCG2
8.296e-05	-9.40	regulation of cytokine production	biological process	GO:0001817	863	10	18204	49	IL6R,CSF1R,HIF1A,DENND1B,IRF5,PLCG2,SYK,PTPN6,ADCY7,CD74
8.372e-05	-9.39	regulation of protein modification process	biological process	GO:0031399	1242	12	18204	49	PIK3R5,SYK,PTPN6,PLCG2,MICAL1,APOE,HIF1A,RGS14,CSF1R,IL6R,CD74,PRKCD
8.604e-05	-9.36	Fc-gamma receptor signaling pathway	biological process	GO:0038094	32	3	18204	49	SYK,PRKCD,VAV3
8.750e-05	-9.34	cellular response to virus	biological process	GO:0098586	87	4	18204	49	WDFY4,IRF5,HIF1A,GSDME
8.754e-05	-9.34	SH2DOMAIN	prints domains	PR00401	72	4	5227	18	PTPN6,SYK,PLCG2,VAV3
9.159e-05	-9.30	negative regulation of MAPK cascade	biological process	GO:0043409	170	5	18204	49	APOE,RGS14,PIK3CB,PRKCD,PTPN6
9.560e-05	-9.26	regulation of leukocyte apoptotic process	biological process	GO:2000106	89	4	18204	49	DOCK8,PIK3CB,CD74,HIF1A
1.034e-04	-9.18	positive T cell selection	biological process	GO:0043368	34	3	18204	49	IL6R,DOCK2,CD74
1.050e-04	-9.16	regulation of interleukin-6 production	biological process	GO:0032675	175	5	18204	49	CD74,SYK,PTPN6,IL6R,PLCG2
1.063e-04	-9.15	regulation of cellular process	biological process	GO:0050794	11468	43	18204	49	PREX1,DOCK2,PRKCD,ELMO1,RGS14,APOE,RIN3,PIK3CB,MICAL1,IRF5,PTPN6,DOCK10,SKAP1,WAS,TBC1D8,NRK,P2RY2,ARHGAP27,ARHGAP33,AKAP13,DOCK8,CD74,RHBDF2,ADCY7,SEMA4A,GMIP,IL6R,CSF1R,HIF1A,SLC4A2,PLCG2,DENND1B,GSDME,GIT2,CARMIL3,DOCK1,NEK6,SYK,VAV3,SBNO2,FYB1,PIK3R5,P2RY6
1.064e-04	-9.15	DOCK_C/D_N	interpro domains	IPR021816	6	2	18521	50	DOCK8,DOCK10
1.071e-04	-9.14	Dedicator of cytokinesis N-terminal subdomain	gene3d domains	1.20.1270.350	5	2	14470	48	DOCK1,DOCK2
1.129e-04	-9.09	granulocyte activation	biological process	GO:0036230	35	3	18204	49	PREX1,SYK,PRKCD
1.129e-04	-9.09	positive regulation of myeloid leukocyte cytokine production involved in immune response	biological process	GO:0061081	35	3	18204	49	PLCG2,SYK,CD74
1.152e-04	-9.07	DOCK_C-D_N	pfam domains	PF11878	6	2	17795	50	DOCK8,DOCK10
1.207e-04	-9.02	bone	COSMIC cancer mutations	bone	8157	35	16828	46	PLCG2,WAS,ELMO1,PTPN6,TBXAS1,VAV3,MICAL1,HIF1A,DOCK1,SLC4A2,PRKCD,RGS14,ADCY7,PIK3CB,MYO1F,DOCK2,CSF1R,ARHGAP27,PREX1,IPCEF1,DOCK10,ARHGAP33,GMIP,WDFY4,DENND1B,DOCK8,RIN3,P2RY2,PARVG,P2RY6,RHBDF2,EHBP1L1,AKAP13,IRF5,TBC1D8
1.229e-04	-9.00	syncytium formation by plasma membrane fusion	biological process	GO:0000768	36	3	18204	49	SBNO2,DOCK1,DOCK2
1.229e-04	-9.00	cell-cell fusion	biological process	GO:0140253	36	3	18204	49	DOCK2,DOCK1,SBNO2
1.258e-04	-8.98	C1	smart domains	SM00109	65	4	9717	39	AKAP13,GMIP,VAV3,PRKCD
1.283e-04	-8.96	integrin-mediated signaling pathway	biological process	GO:0007229	96	4	18204	49	VAV3,FYB1,SYK,DOCK1
1.327e-04	-8.93	mouth	COSMIC cancer mutations	mouth	9004	37	16828	46	DOCK10,ARHGAP33,WDFY4,GMIP,DOCK8,DENND1B,SBNO2,PREX1,RHBDF2,EHBP1L1,AKAP13,IRF5,CD74,TBC1D8,NEK6,APOE,RIN3,P2RY2,PARVG,SYK,TBXAS1,VAV3,MICAL1,PLCG2,WAS,ELMO1,PTPN6,ADCY7,PIK3CB,MYO1F,GIT2,DOCK2,CSF1R,DOCK1,SLC4A2,RGS14,PRKCD
1.334e-04	-8.92	Calponin-like domain	gene3d domains	1.10.418.10	79	4	14470	48	MICAL1,PARVG,EHBP1L1,VAV3
1.335e-04	-8.92	negative regulation of lymphocyte apoptotic process	biological process	GO:0070229	37	3	18204	49	HIF1A,CD74,DOCK8
1.335e-04	-8.92	CH	smart domains	SM00033	66	4	9717	39	EHBP1L1,VAV3,MICAL1,PARVG
1.340e-04	-8.92	regulation of endocytosis	biological process	GO:0030100	295	6	18204	49	DOCK2,SYK,PLCG2,RIN3,PIK3CB,APOE
1.363e-04	-8.90	DOCK5 (dedicator of cytokinesis 5)	protein interactions	80005	102	4	19454	50	GIT2,ELMO1,DOCK1,PIK3CB
1.384e-04	-8.89	regulation of inflammatory response	biological process	GO:0050727	428	7	18204	49	APOE,SBNO2,PTPN6,PRKCD,SYK,RHBDF2,PLCG2
1.394e-04	-8.88	Fc epsilon RI signaling pathway	KEGG pathways	hsa04664	67	4	7161	29	VAV3,PIK3CB,PLCG2,SYK
1.394e-04	-8.88	Fc epsilon RI signaling pathway	KEGG pathways	ko04664	67	4	7161	29	VAV3,PIK3CB,PLCG2,SYK
1.445e-04	-8.84	response to wounding	biological process	GO:0009611	431	7	18204	49	SYK,PTPN6,PLCG2,HIF1A,PIK3CB,VAV3,WAS
1.468e-04	-8.83	regulation of epithelial cell migration	biological process	GO:0010632	300	6	18204	49	PIK3CB,HIF1A,APOE,PLCG2,SEMA4A,DOCK1
1.474e-04	-8.82	regulation of response to external stimulus	biological process	GO:0032101	1116	11	18204	49	PRKCD,CD74,RHBDF2,CSF1R,IL6R,RIN3,APOE,PLCG2,PTPN6,SYK,SBNO2
1.478e-04	-8.82	vascular endothelial growth factor production	biological process	GO:0010573	7	2	18204	49	HIF1A,IL6R
1.483e-04	-8.82	regulation of biological process	biological process	GO:0050789	12079	44	18204	49	PREX1,PRKCD,DOCK2,APOE,RGS14,PIK3CB,RIN3,ELMO1,PTPN6,DOCK10,IRF5,MICAL1,TBC1D8,NRK,SKAP1,WAS,RHBDF2,ADCY7,CD74,SEMA4A,GMIP,ARHGAP33,AKAP13,ARHGAP27,P2RY2,DOCK8,HIF1A,CSF1R,IL6R,GIT2,GSDME,SYK,DOCK1,CARMIL3,NEK6,PLCG2,SLC4A2,DENND1B,PIK3R5,P2RY6,VAV3,SBNO2,TBXAS1,FYB1
1.499e-04	-8.81	FCERI mediated Ca+2 mobilization	REACTOME pathways	R-HSA-2871809	30	3	10285	36	PLCG2,VAV3,SYK
1.502e-04	-8.80	positive regulation of interleukin-6 production	biological process	GO:0032755	100	4	18204	49	SYK,CD74,PLCG2,IL6R
1.506e-04	-8.80	regulation of production of molecular mediator of immune response	biological process	GO:0002700	189	5	18204	49	CD74,SYK,IRF5,PLCG2,DENND1B
1.527e-04	-8.79	SH3DOMAIN	prints domains	PR00452	83	4	5227	18	VAV3,PLCG2,SKAP1,MYO1F
1.565e-04	-8.76	syncytium formation	biological process	GO:0006949	39	3	18204	49	SBNO2,DOCK1,DOCK2
1.599e-04	-8.74	Rap1 signaling pathway	KEGG pathways	ko04015	210	6	7161	29	PIK3CB,ADCY7,FYB1,CSF1R,SKAP1,RGS14
1.599e-04	-8.74	Rap1 signaling pathway	KEGG pathways	hsa04015	210	6	7161	29	SKAP1,CSF1R,RGS14,FYB1,PIK3CB,ADCY7
1.622e-04	-8.73	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	46	16828	46	SLC4A2,RGS14,ADCY7,MYO1F,GIT2,ELMO1,PTPN6,VAV3,PARVG,EHBP1L1,IRF5,WDFY4,DENND1B,DOCK8,HIF1A,DOCK1,PIK3R5,PRKCD,PIK3CB,DOCK2,CSF1R,PLCG2,WAS,TBXAS1,MICAL1,APOE,GLIPR1,RIN3,P2RY2,P2RY6,SYK,RHBDF2,IL6R,AKAP13,CD74,TBC1D8,NEK6,ARHGAP27,PREX1,IPCEF1,DOCK10,SEMA4A,ARHGAP33,SKAP1,GMIP,SBNO2
1.622e-04	-8.73	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	46	16828	46	PTPN6,ELMO1,VAV3,SLC4A2,RGS14,ADCY7,MYO1F,GIT2,DOCK8,DENND1B,WDFY4,PARVG,EHBP1L1,IRF5,WAS,PLCG2,MICAL1,TBXAS1,PRKCD,HIF1A,DOCK1,PIK3R5,CSF1R,PIK3CB,DOCK2,ARHGAP27,PREX1,IPCEF1,SBNO2,SEMA4A,DOCK10,ARHGAP33,SKAP1,GMIP,P2RY2,P2RY6,SYK,APOE,RIN3,GLIPR1,TBC1D8,NEK6,RHBDF2,IL6R,AKAP13,CD74
1.642e-04	-8.71	Natural killer cell mediated cytotoxicity	KEGG pathways	ko04650	132	5	7161	29	PIK3CB,VAV3,PTPN6,SYK,PLCG2
1.642e-04	-8.71	Natural killer cell mediated cytotoxicity	KEGG pathways	hsa04650	132	5	7161	29	VAV3,PIK3CB,PLCG2,PTPN6,SYK
1.687e-04	-8.69	response to organic substance	biological process	GO:0010033	2498	17	18204	49	IL6R,CSF1R,HIF1A,P2RY2,DOCK8,CD74,ADCY7,PRKCD,SBNO2,WAS,TBXAS1,P2RY6,PLCG2,IRF5,GSDME,PTPN6,SYK
1.709e-04	-8.67	PRAM1 (PML-RARA regulated adaptor molecule 1)	protein interactions	84106	42	3	19454	50	SKAP1,NEK6,APOE
1.754e-04	-8.65	PH	pfam domains	PF00169	187	5	17795	50	DOCK10,VAV3,IPCEF1,SKAP1,ARHGAP27
1.773e-04	-8.64	SH2	pfam domains	PF00017	100	4	17795	50	PTPN6,VAV3,SYK,PLCG2
1.870e-04	-8.58	SH2 domain binding	molecular function	GO:0042169	42	3	18094	48	SKAP1,PTPN6,SYK
1.910e-04	-8.56	phosphorylation-dependent protein binding	molecular function	GO:0140031	8	2	18094	48	PTPN6,PLCG2
1.979e-04	-8.53	bMERB_dom	interpro domains	IPR022735	8	2	18521	50	EHBP1L1,MICAL1
2.007e-04	-8.51	negative regulation of inflammatory response	biological process	GO:0050728	201	5	18204	49	RHBDF2,APOE,PRKCD,SYK,PTPN6
2.060e-04	-8.49	anatomical structure formation involved in morphogenesis	biological process	GO:0048646	964	10	18204	49	PTPN6,DOCK2,DOCK1,SEMA4A,SYK,SLC4A2,PIK3CB,HIF1A,SBNO2,VAV3
2.097e-04	-8.47	regulation of bone resorption	biological process	GO:0045124	43	3	18204	49	SYK,SLC4A2,CSF1R
2.097e-04	-8.47	positive regulation of interleukin-12 production	biological process	GO:0032735	43	3	18204	49	PLCG2,IRF5,SYK
2.101e-04	-8.47	EPOR (erythropoietin receptor)	protein interactions	2057	45	3	19454	50	SYK,PTPN6,PLCG2
2.143e-04	-8.45	bMERB_dom	pfam domains	PF12130	8	2	17795	50	EHBP1L1,MICAL1
2.179e-04	-8.43	functioning	COSMIC cancer mutations	functioning	1803	14	16828	46	DOCK2,ADCY7,CSF1R,DOCK1,RIN3,RGS14,SLC4A2,WDFY4,SKAP1,SBNO2,DOCK8,IPCEF1,PTPN6,ELMO1
2.179e-04	-8.43	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	14	16828	46	DOCK2,ADCY7,CSF1R,DOCK1,RIN3,RGS14,SLC4A2,WDFY4,SKAP1,SBNO2,DOCK8,IPCEF1,PTPN6,ELMO1
2.194e-04	-8.42	CH	prosite domains	PS50021	81	4	12186	45	PARVG,MICAL1,VAV3,EHBP1L1
2.276e-04	-8.39	Bacterial invasion of epithelial cells	KEGG pathways	ko05100	76	4	7161	29	ELMO1,PIK3CB,DOCK1,WAS
2.276e-04	-8.39	Bacterial invasion of epithelial cells	KEGG pathways	hsa05100	76	4	7161	29	PIK3CB,DOCK1,WAS,ELMO1
2.304e-04	-8.38	KLRA1P (killer cell lectin like receptor A1, pseudogene)	protein interactions	10748	9	2	19454	50	SYK,PTPN6
2.388e-04	-8.34	phosphatidylinositol 3-kinase complex, class I	cellular component	GO:0097651	9	2	19108	50	PIK3R5,PIK3CB
2.388e-04	-8.34	phosphatidylinositol 3-kinase complex, class IA	cellular component	GO:0005943	9	2	19108	50	PIK3CB,PIK3R5
2.405e-04	-8.33	regulation of adaptive immune response	biological process	GO:0002819	209	5	18204	49	SKAP1,DENND1B,WAS,ADCY7,PTPN6
2.532e-04	-8.28	regulation of cell activation	biological process	GO:0050865	630	8	18204	49	SLC4A2,DOCK8,CD74,PTPN6,PRKCD,SYK,VAV3,APOE
2.549e-04	-8.27	Phospholipase D signaling pathway	KEGG pathways	hsa04072	145	5	7161	29	PLCG2,SYK,ADCY7,PIK3R5,PIK3CB
2.549e-04	-8.27	Phospholipase D signaling pathway	KEGG pathways	ko04072	145	5	7161	29	PIK3R5,ADCY7,PIK3CB,PLCG2,SYK
2.617e-04	-8.25	phosphotyrosine residue binding	molecular function	GO:0001784	47	3	18094	48	PLCG2,SYK,PTPN6
2.683e-04	-8.22	negative regulation of cell activation	biological process	GO:0050866	214	5	18204	49	SLC4A2,APOE,CD74,PRKCD,PTPN6
2.693e-04	-8.22	CBL (Cbl proto-oncogene)	protein interactions	867	499	7	19454	50	PIK3CB,CSF1R,FYB1,PTPN6,WAS,HIF1A,SYK
2.734e-04	-8.20	negative regulation of MAP kinase activity	biological process	GO:0043407	47	3	18204	49	PRKCD,APOE,RGS14
2.751e-04	-8.20	PH_12	pfam domains	PF16457	9	2	17795	50	ELMO1,PLCG2
2.800e-04	-8.18	cell chemotaxis	biological process	GO:0060326	216	5	18204	49	VAV3,IL6R,SYK,PRKCD,PREX1
2.838e-04	-8.17	regulation of receptor-mediated endocytosis	biological process	GO:0048259	118	4	18204	49	RIN3,PIK3CB,SYK,PLCG2
2.854e-04	-8.16	ARM-type_fold	interpro domains	IPR016024	338	6	18521	50	PIK3CB,WDFY4,DOCK1,ELMO1,DOCK2,DOCK8
2.911e-04	-8.14	icosanoid biosynthetic process	biological process	GO:0046456	48	3	18204	49	SYK,CD74,TBXAS1
2.986e-04	-8.12	lung-carcinoma-undifferentiated_carcinoma	COSMIC cancer mutations	lung-carcinoma-undifferentiated_carcinoma	1408	12	16828	46	CSF1R,PIK3CB,P2RY6,SYK,PRKCD,P2RY2,RIN3,PIK3R5,VAV3,PTPN6,WAS,PLCG2
3.095e-04	-8.08	regulation of cell adhesion mediated by integrin	biological process	GO:0033628	49	3	18204	49	SKAP1,SYK,PTPN6
3.188e-04	-8.05	undifferentiated_carcinoma	COSMIC cancer mutations	undifferentiated_carcinoma	1418	12	16828	46	CSF1R,PIK3CB,PRKCD,P2RY6,SYK,P2RY2,PIK3R5,RIN3,VAV3,PTPN6,WAS,PLCG2
3.223e-04	-8.04	regulation of leukocyte chemotaxis	biological process	GO:0002688	122	4	18204	49	IL6R,CSF1R,RIN3,CD74
3.258e-04	-8.03	GAB2 (GRB2 associated binding protein 2)	protein interactions	9846	128	4	19454	50	PIK3CB,PLCG2,PTPN6,SYK
3.292e-04	-8.02	Nef and signal transduction	REACTOME pathways	R-HSA-164944	8	2	10285	36	ELMO1,DOCK2
3.301e-04	-8.02	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME pathways	R-HSA-983695	39	3	10285	36	SYK,PLCG2,PTPN6
3.397e-04	-7.99	breast-carcinoma-ER-PR-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-ER-PR-positive_carcinoma	1881	14	16828	46	PLCG2,WAS,ELMO1,PTPN6,DOCK10,VAV3,RIN3,PIK3R5,P2RY2,SYK,P2RY6,PRKCD,PIK3CB,CSF1R
3.397e-04	-7.99	ER-PR-positive_carcinoma	COSMIC cancer mutations	ER-PR-positive_carcinoma	1881	14	16828	46	PLCG2,WAS,ELMO1,PTPN6,DOCK10,VAV3,RIN3,PIK3R5,P2RY2,SYK,PRKCD,P2RY6,PIK3CB,CSF1R
3.419e-04	-7.98	ELMO2 (engulfment and cell motility 2)	protein interactions	63916	53	3	19454	50	DOCK1,DOCK2,ELMO1
3.474e-04	-7.97	regulation of cellular component size	biological process	GO:0032535	352	6	18204	49	PREX1,APOE,RIN3,PRKCD,VAV3,WAS
3.485e-04	-7.96	regulation of bone remodeling	biological process	GO:0046850	51	3	18204	49	SLC4A2,CSF1R,SYK
3.577e-04	-7.94	regulation of cell-cell adhesion	biological process	GO:0022407	500	7	18204	49	CD74,PRKCD,SYK,PTPN6,SKAP1,SLC4A2,DOCK8
3.668e-04	-7.91	NHLRC2 (NHL repeat containing 2)	protein interactions	374354	372	6	19454	50	TBXAS1,MYO1F,DOCK10,AKAP13,SYK,PRKCD
3.681e-04	-7.91	BMERB	prosite domains	PS51848	8	2	12186	45	MICAL1,EHBP1L1
3.801e-04	-7.88	regulation of biological quality	biological process	GO:0065008	2936	18	18204	49	SLC4A2,PLCG2,PTPN6,SYK,TBXAS1,WAS,VAV3,P2RY2,ARHGAP33,PRKCD,SEMA4A,PREX1,CSF1R,RIN3,PIK3CB,RGS14,APOE,HIF1A
3.812e-04	-7.87	regulation of leukocyte migration	biological process	GO:0002685	231	5	18204	49	IL6R,CSF1R,DOCK8,CD74,RIN3
3.847e-04	-7.86	actin cytoskeleton	cellular component	GO:0015629	520	7	19108	50	WAS,ARHGAP33,AKAP13,PARVG,MYO1F,MICAL1,FYB1
3.868e-04	-7.86	regulation of B cell activation	biological process	GO:0050864	128	4	18204	49	VAV3,SYK,PTPN6,CD74
3.906e-04	-7.85	regulation of platelet activation	biological process	GO:0010543	53	3	18204	49	APOE,SYK,PRKCD
4.092e-04	-7.80	adaptive immune response	biological process	GO:0002250	363	6	18204	49	SYK,SEMA4A,PRKCD,CD74,SKAP1,IL6R
4.102e-04	-7.80	lymphocyte proliferation	biological process	GO:0046651	130	4	18204	49	DOCK2,PTPN6,PRKCD,DOCK8
4.203e-04	-7.77	RWDD1 (RWD domain containing 1)	protein interactions	51389	12	2	19454	50	CD74,P2RY6
4.322e-04	-7.75	regulation of vesicle-mediated transport	biological process	GO:0060627	516	7	18204	49	APOE,RIN3,PIK3CB,DOCK2,SYK,MICAL1,PLCG2
4.329e-04	-7.75	DUF3585	smart domains	SM01203	8	2	9717	39	EHBP1L1,MICAL1
4.357e-04	-7.74	neutrophil chemotaxis	biological process	GO:0030593	55	3	18204	49	SYK,PREX1,VAV3
4.578e-04	-7.69	regulation of cytoskeleton organization	biological process	GO:0051493	521	7	18204	49	PREX1,CARMIL3,PRKCD,SLC4A2,CSF1R,AKAP13,WAS
4.595e-04	-7.69	negative regulation of leukocyte apoptotic process	biological process	GO:2000107	56	3	18204	49	HIF1A,CD74,DOCK8
4.601e-04	-7.68	mononuclear cell proliferation	biological process	GO:0032943	134	4	18204	49	DOCK8,DOCK2,PTPN6,PRKCD
4.605e-04	-7.68	positive thymic T cell selection	biological process	GO:0045059	12	2	18204	49	DOCK2,CD74
4.605e-04	-7.68	negative thymic T cell selection	biological process	GO:0045060	12	2	18204	49	CD74,DOCK2
4.616e-04	-7.68	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	5	19454	50	DOCK1,FYB1,GIT2,WAS,MICAL1
4.842e-04	-7.63	osteoclast differentiation	biological process	GO:0030316	57	3	18204	49	CSF1R,SLC4A2,SBNO2
4.842e-04	-7.63	regulation of lymphocyte apoptotic process	biological process	GO:0070228	57	3	18204	49	CD74,HIF1A,DOCK8
4.845e-04	-7.63	biological regulation	biological process	GO:0065007	12501	44	18204	49	RGS14,APOE,PREX1,SKAP1,TBC1D8,NRK,IRF5,PTPN6,CSF1R,IL6R,AKAP13,ARHGAP33,CD74,GMIP,SBNO2,TBXAS1,P2RY6,SLC4A2,GIT2,NEK6,CARMIL3,SYK,ELMO1,RIN3,PIK3CB,DOCK2,PRKCD,WAS,MICAL1,DOCK10,HIF1A,ARHGAP27,P2RY2,DOCK8,ADCY7,RHBDF2,SEMA4A,VAV3,FYB1,PIK3R5,PLCG2,DENND1B,GSDME,DOCK1
4.866e-04	-7.63	regulation of MAP kinase activity	biological process	GO:0043405	136	4	18204	49	APOE,PIK3R5,RGS14,PRKCD
4.959e-04	-7.61	FCRL3 (Fc receptor like 3)	protein interactions	115352	13	2	19454	50	SYK,PTPN6
4.959e-04	-7.61	RINL (Ras and Rab interactor like)	protein interactions	126432	13	2	19454	50	MICAL1,RIN3
4.970e-04	-7.61	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	21	16828	46	DOCK1,PRKCD,SYK,SLC4A2,PIK3CB,DOCK2,GIT2,AKAP13,CSF1R,TBC1D8,IPCEF1,PLCG2,ELMO1,PTPN6,SKAP1,WDFY4,GMIP,DOCK10,ARHGAP33,DENND1B,SBNO2
4.970e-04	-7.61	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	21	16828	46	DOCK1,SLC4A2,SYK,PRKCD,AKAP13,GIT2,DOCK2,PIK3CB,TBC1D8,CSF1R,PLCG2,IPCEF1,ELMO1,PTPN6,ARHGAP33,DOCK10,WDFY4,GMIP,SKAP1,SBNO2,DENND1B
4.982e-04	-7.60	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	8	18204	49	IL6R,CSF1R,P2RY6,PIK3R5,PLCG2,PRKCD,SYK,CD74
4.982e-04	-7.60	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	8	18204	49	P2RY6,PIK3R5,CSF1R,IL6R,PRKCD,SYK,CD74,PLCG2
4.987e-04	-7.60	leukocyte migration	biological process	GO:0050900	245	5	18204	49	DOCK8,IL6R,VAV3,SYK,PREX1
5.002e-04	-7.60	myeloid leukocyte migration	biological process	GO:0097529	137	4	18204	49	SYK,PREX1,VAV3,IL6R
5.129e-04	-7.58	regulation of kinase activity	biological process	GO:0043549	531	7	18204	49	PRKCD,CD74,PIK3R5,RGS14,APOE,IL6R,CSF1R
5.175e-04	-7.57	regulation of leukocyte mediated immunity	biological process	GO:0002703	247	5	18204	49	PLCG2,DENND1B,WAS,SYK,PTPN6
5.276e-04	-7.55	G protein-coupled purinergic nucleotide receptor activity	molecular function	GO:0045028	13	2	18094	48	P2RY6,P2RY2
5.276e-04	-7.55	insulin receptor substrate binding	molecular function	GO:0043560	13	2	18094	48	PIK3CB,PRKCD
5.284e-04	-7.55	positive regulation of transferase activity	biological process	GO:0051347	381	6	18204	49	CD74,PRKCD,APOE,PIK3R5,CSF1R,IL6R
5.392e-04	-7.53	protein phosphorylated amino acid binding	molecular function	GO:0045309	60	3	18094	48	PLCG2,PTPN6,SYK
5.432e-04	-7.52	negative T cell selection	biological process	GO:0043383	13	2	18204	49	DOCK2,CD74
5.432e-04	-7.52	G protein-coupled purinergic nucleotide receptor signaling pathway	biological process	GO:0035589	13	2	18204	49	P2RY6,P2RY2
5.460e-04	-7.51	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	29	16828	46	PREX1,GMIP,WDFY4,DOCK10,ARHGAP33,DOCK8,SBNO2,RIN3,APOE,SYK,P2RY2,IRF5,CD74,RHBDF2,AKAP13,NEK6,TBC1D8,PLCG2,PTPN6,ELMO1,TBXAS1,PRKCD,RGS14,SLC4A2,PIK3CB,MYO1F,GIT2,DOCK2,ADCY7
5.507e-04	-7.50	cytokine-mediated signaling pathway	biological process	GO:0019221	384	6	18204	49	CSF1R,IL6R,IRF5,PTPN6,SYK,CD74
5.507e-04	-7.50	regulation of leukocyte cell-cell adhesion	biological process	GO:1903037	384	6	18204	49	SKAP1,SLC4A2,DOCK8,CD74,PTPN6,SYK
5.776e-04	-7.46	LYSMD2 (LysM domain containing 2)	protein interactions	256586	14	2	19454	50	PRKCD,HIF1A
5.815e-04	-7.45	regulation of supramolecular fiber organization	biological process	GO:1902903	388	6	18204	49	PREX1,APOE,PRKCD,CARMIL3,AKAP13,WAS
5.854e-04	-7.44	Signaling by Rho GTPases	REACTOME pathways	R-HSA-194315	426	7	10285	36	VAV3,ARHGAP27,WAS,GMIP,PREX1,AKAP13,ARHGAP33
5.865e-04	-7.44	Regulation of toll-like receptor signaling pathway	WikiPathways	WP1449	145	5	5310	26	PIK3CB,IRF5,PTPN6,PIK3R5,SYK
5.967e-04	-7.42	C1-like_sf	interpro domains	IPR046349	61	3	18521	50	AKAP13,GMIP,PRKCD
5.990e-04	-7.42	tube development	biological process	GO:0035295	903	9	18204	49	PTPN6,SEMA4A,SYK,SLC4A2,PIK3CB,APOE,HIF1A,VAV3,CSF1R
6.118e-04	-7.40	actin cytoskeleton organization	biological process	GO:0030036	547	7	18204	49	PREX1,DOCK2,MICAL1,MYO1F,PARVG,ELMO1,WAS
6.199e-04	-7.39	macrophage activation	biological process	GO:0042116	62	3	18204	49	SBNO2,PLCG2,SYK
6.327e-04	-7.37	immunological synapse formation	biological process	GO:0001771	14	2	18204	49	DOCK2,DOCK8
6.497e-04	-7.34	regulation of receptor internalization	biological process	GO:0002090	63	3	18204	49	PLCG2,SYK,RIN3
6.521e-04	-7.34	leukocyte chemotaxis	biological process	GO:0030595	147	4	18204	49	VAV3,IL6R,PREX1,SYK
6.625e-04	-7.32	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	15	16828	46	SBNO2,DOCK8,MICAL1,WDFY4,SKAP1,ELMO1,PTPN6,IPCEF1,CSF1R,ADCY7,DOCK2,SLC4A2,RGS14,RIN3,DOCK1
6.645e-04	-7.32	receptor complex	cellular component	GO:0043235	409	6	19108	50	IL6R,CSF1R,SKAP1,PTPN6,CD74,SYK
6.689e-04	-7.31	regulation of reactive oxygen species metabolic process	biological process	GO:2000377	148	4	18204	49	PLCG2,HIF1A,PRKCD,SYK
6.714e-04	-7.31	regulation of localization	biological process	GO:0032879	2028	14	18204	49	P2RY2,PRKCD,DOCK2,RHBDF2,CD74,PIK3CB,RIN3,HIF1A,APOE,PLCG2,MICAL1,SYK,PTPN6,P2RY6
6.753e-04	-7.30	HIF-1 signaling pathway	KEGG pathways	hsa04066	101	4	7161	29	HIF1A,PLCG2,IL6R,PIK3CB
6.803e-04	-7.29	actin polymerization or depolymerization	biological process	GO:0008154	64	3	18204	49	PREX1,MICAL1,WAS
6.803e-04	-7.29	regulation of interleukin-12 production	biological process	GO:0032655	64	3	18204	49	SYK,PLCG2,IRF5
6.860e-04	-7.28	positive regulation of leukocyte migration	biological process	GO:0002687	149	4	18204	49	CD74,DOCK8,CSF1R,IL6R
7.136e-04	-7.25	multicellular organismal process	biological process	GO:0032501	6177	28	18204	49	TBC1D8,WAS,DOCK10,PTPN6,PIK3CB,APOE,RGS14,PRKCD,DOCK2,PREX1,TBXAS1,VAV3,SBNO2,SYK,GIT2,GSDME,PLCG2,SLC4A2,HIF1A,IL6R,CSF1R,SEMA4A,ADCY7,CD74,DOCK8,AKAP13,WDFY4,P2RY2
7.188e-04	-7.24	RhoGAP_dom	interpro domains	IPR000198	65	3	18521	50	ARHGAP27,GMIP,ARHGAP33
7.288e-04	-7.22	regulation of phospholipid transport	biological process	GO:2001138	15	2	18204	49	APOE,PRKCD
7.320e-04	-7.22	regulation of programmed cell death	biological process	GO:0043067	1569	12	18204	49	CSF1R,PIK3CB,HIF1A,DOCK8,PRKCD,CD74,MICAL1,PLCG2,IRF5,PTPN6,SYK,GSDME
7.444e-04	-7.20	peptidyl-tyrosine phosphorylation	biological process	GO:0018108	66	3	18204	49	CSF1R,PTPN6,SYK
7.444e-04	-7.20	neutrophil migration	biological process	GO:1990266	66	3	18204	49	VAV3,SYK,PREX1
7.484e-04	-7.20	regulation of leukocyte proliferation	biological process	GO:0070663	268	5	18204	49	CD74,PTPN6,SLC4A2,VAV3,CSF1R
7.488e-04	-7.20	TRAF6 (TNF receptor associated factor 6)	protein interactions	7189	426	6	19454	50	PRKCD,IRF5,SYK,HIF1A,VAV3,PTPN6
7.592e-04	-7.18	IL1RL2 (interleukin 1 receptor like 2)	protein interactions	8808	16	2	19454	50	MYO1F,MICAL1
7.592e-04	-7.18	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	2	19454	50	APOE,RIN3
7.592e-04	-7.18	TAMALIN (trafficking regulator and scaffold protein tamalin)	protein interactions	160622	16	2	19454	50	DOCK1,SYK
7.691e-04	-7.17	P2Y receptors	REACTOME pathways	R-HSA-417957	12	2	10285	36	P2RY6,P2RY2
7.739e-04	-7.16	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051896	270	5	18204	49	PIK3R5,PIK3CB,PTPN6,CSF1R,VAV3
7.747e-04	-7.16	INPP5D (inositol polyphosphate-5-phosphatase D)	protein interactions	3635	70	3	19454	50	CSF1R,PRKCD,SYK
7.747e-04	-7.16	IL6ST (interleukin 6 cytokine family signal transducer)	protein interactions	3572	70	3	19454	50	PRKCD,PTPN6,IL6R
8.065e-04	-7.12	RhoGAP	pfam domains	PF00620	65	3	17795	50	ARHGAP33,GMIP,ARHGAP27
8.122e-04	-7.12	peptidyl-tyrosine modification	biological process	GO:0018212	68	3	18204	49	SYK,PTPN6,CSF1R
8.129e-04	-7.11	positive regulation of protein phosphorylation	biological process	GO:0001934	574	7	18204	49	PRKCD,SYK,CD74,PLCG2,PIK3R5,CSF1R,IL6R
8.342e-04	-7.09	positive regulation of endocytosis	biological process	GO:0045807	157	4	18204	49	PLCG2,DOCK2,SYK,APOE
8.590e-04	-7.06	ARL4A (ADP ribosylation factor like GTPase 4A)	protein interactions	10124	17	2	19454	50	ELMO1,DOCK1
8.686e-04	-7.05	regulation of protein-containing complex assembly	biological process	GO:0043254	419	6	18204	49	PREX1,PRKCD,SYK,PLCG2,APOE,SKAP1
8.754e-04	-7.04	TLR9 (toll like receptor 9)	protein interactions	54106	73	3	19454	50	PRKCD,SYK,MICAL1
8.810e-04	-7.03	CH	pfam domains	PF00307	67	3	17795	50	MICAL1,EHBP1L1,PARVG
8.822e-04	-7.03	actin filament organization	biological process	GO:0007015	278	5	18204	49	PREX1,MICAL1,ELMO1,MYO1F,WAS
8.838e-04	-7.03	positive regulation of reactive oxygen species metabolic process	biological process	GO:2000379	70	3	18204	49	PRKCD,SYK,PLCG2
8.923e-04	-7.02	DH-domain	interpro domains	IPR000219	70	3	18521	50	VAV3,PREX1,AKAP13
8.965e-04	-7.02	positive regulation of leukocyte cell-cell adhesion	biological process	GO:1903039	279	5	18204	49	CD74,SYK,PTPN6,SKAP1,DOCK8
9.069e-04	-7.01	Signal regulatory protein (SIRP) family interactions	REACTOME pathways	R-HSA-391160	13	2	10285	36	FYB1,PTPN6
9.299e-04	-6.98	DBL_dom_sf	interpro domains	IPR035899	71	3	18521	50	AKAP13,VAV3,PREX1
9.308e-04	-6.98	nef (Nef)	protein interactions	156110	802	8	19454	50	CSF1R,PIK3CB,SYK,DOCK2,ELMO1,CD74,PRKCD,ADCY7
9.644e-04	-6.94	Innate Immune System	REACTOME pathways	R-HSA-168249	1285	12	10285	36	PRKCD,PIK3CB,PTPN6,GLIPR1,VAV3,SYK,DOCK1,DOCK2,ADCY7,PLCG2,ELMO1,WAS
9.685e-04	-6.94	PLSCR1 (phospholipid scramblase 1)	protein interactions	5359	171	4	19454	50	P2RY6,DOCK2,ADCY7,PRKCD
9.696e-04	-6.94	negative regulation of response to external stimulus	biological process	GO:0032102	428	6	18204	49	APOE,RIN3,RHBDF2,SYK,PRKCD,PTPN6
1.001e-03	-6.91	RhoGEF	pfam domains	PF00621	70	3	17795	50	VAV3,AKAP13,PREX1
1.002e-03	-6.91	G protein-coupled receptor signaling pathway	biological process	GO:0007186	1178	10	18204	49	PTPN6,ADCY7,PREX1,P2RY2,AKAP13,P2RY6,PIK3CB,RGS14,PIK3R5,APOE
1.043e-03	-6.87	negative regulation of intracellular signal transduction	biological process	GO:1902532	599	7	18204	49	PIK3CB,APOE,HIF1A,RGS14,PRKCD,PTPN6,CD74
1.054e-03	-6.85	blood vessel morphogenesis	biological process	GO:0048514	435	6	18204	49	VAV3,PIK3CB,APOE,HIF1A,SYK,SEMA4A
1.056e-03	-6.85	positive regulation of type 2 immune response	biological process	GO:0002830	18	2	18204	49	DENND1B,CD74
1.056e-03	-6.85	positive regulation of superoxide anion generation	biological process	GO:0032930	18	2	18204	49	SYK,PRKCD
1.056e-03	-6.85	negative regulation of platelet activation	biological process	GO:0010544	18	2	18204	49	APOE,PRKCD
1.079e-03	-6.83	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	6	18204	49	PIK3CB,APOE,HIF1A,TBXAS1,SLC4A2,P2RY2
1.080e-03	-6.83	positive regulation of type I interferon production	biological process	GO:0032481	75	3	18204	49	SYK,PLCG2,IRF5
1.099e-03	-6.81	negative regulation of protein phosphorylation	biological process	GO:0001933	292	5	18204	49	APOE,RGS14,PRKCD,PTPN6,MICAL1
1.105e-03	-6.81	regulation of secretion	biological process	GO:0051046	605	7	18204	49	APOE,HIF1A,MICAL1,P2RY2,SYK,CD74,RHBDF2
1.115e-03	-6.80	negative regulation of defense response	biological process	GO:0031348	293	5	18204	49	APOE,RHBDF2,PTPN6,SYK,PRKCD
1.122e-03	-6.79	T cell proliferation	biological process	GO:0042098	76	3	18204	49	DOCK2,PTPN6,DOCK8
1.122e-03	-6.79	alpha-beta T cell differentiation	biological process	GO:0046632	76	3	18204	49	SEMA4A,SYK,IL6R
1.124e-03	-6.79	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	4	19454	50	PTPN6,SYK,PLCG2,VAV3
1.162e-03	-6.76	regulation of organelle organization	biological process	GO:0033043	1201	10	18204	49	PREX1,NEK6,CARMIL3,PRKCD,SLC4A2,AKAP13,TBC1D8,HIF1A,CSF1R,WAS
1.175e-03	-6.75	NRAGE signals death through JNK	REACTOME pathways	R-HSA-193648	60	3	10285	36	VAV3,PREX1,AKAP13
1.194e-03	-6.73	B Cell Receptor Signaling Pathway	WikiPathways	WP23	98	4	5310	26	PTPN6,SYK,PLCG2,PRKCD
1.204e-03	-6.72	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	22	16828	46	ADCY7,DOCK2,MYO1F,SLC4A2,PIK3R5,DOCK1,ELMO1,TBC1D8,AKAP13,EHBP1L1,RHBDF2,IRF5,PARVG,P2RY6,RIN3,SBNO2,DOCK8,DOCK10,GMIP,WDFY4,PREX1,IPCEF1
1.204e-03	-6.72	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	22	16828	46	MYO1F,IRF5,DOCK2,EHBP1L1,ADCY7,RHBDF2,AKAP13,TBC1D8,PIK3R5,RIN3,DOCK1,P2RY6,SLC4A2,PARVG,GMIP,WDFY4,DOCK10,DOCK8,SBNO2,IPCEF1,PREX1,ELMO1
1.212e-03	-6.72	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	44	16828	46	RIN3,GLIPR1,APOE,SYK,P2RY6,P2RY2,CD74,RHBDF2,IL6R,AKAP13,NEK6,TBC1D8,PREX1,SKAP1,GMIP,SEMA4A,DOCK10,ARHGAP33,SBNO2,PIK3R5,DOCK1,HIF1A,PRKCD,PIK3CB,DOCK2,CSF1R,PLCG2,WAS,TBXAS1,MICAL1,PARVG,IRF5,EHBP1L1,WDFY4,DENND1B,DOCK8,RGS14,SLC4A2,MYO1F,GIT2,ADCY7,ELMO1,PTPN6,VAV3
1.227e-03	-6.70	actin filament-based process	biological process	GO:0030029	616	7	18204	49	WAS,MYO1F,MICAL1,ELMO1,DOCK2,PARVG,PREX1
1.234e-03	-6.70	Nucleotide GPCRs	WikiPathways	WP80	11	2	5310	26	P2RY2,P2RY6
1.245e-03	-6.69	HCK (HCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3055	183	4	19454	50	ELMO1,PLCG2,PIK3CB,WAS
1.255e-03	-6.68	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	11	19454	50	PLCG2,PIK3CB,HIF1A,APOE,PRKCD,CD74,SKAP1,ADCY7,IL6R,WAS,VAV3
1.261e-03	-6.68	positive regulation of phosphorylation	biological process	GO:0042327	619	7	18204	49	IL6R,CSF1R,PIK3R5,PLCG2,SYK,PRKCD,CD74
1.270e-03	-6.67	nucleotide receptor activity	molecular function	GO:0016502	20	2	18094	48	P2RY6,P2RY2
1.270e-03	-6.67	purinergic nucleotide receptor activity	molecular function	GO:0001614	20	2	18094	48	P2RY6,P2RY2
1.274e-03	-6.67	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002460	176	4	18204	49	CD74,PRKCD,SEMA4A,IL6R
1.276e-03	-6.66	positive regulation of kinase activity	biological process	GO:0033674	302	5	18204	49	PIK3R5,CD74,PRKCD,CSF1R,IL6R
1.290e-03	-6.65	defense response to other organism	biological process	GO:0098542	1006	9	18204	49	WAS,IL6R,CSF1R,IRF5,PLCG2,PTPN6,SYK,PRKCD,CD74
1.307e-03	-6.64	regulation of antigen processing and presentation	biological process	GO:0002577	20	2	18204	49	WAS,CD74
1.332e-03	-6.62	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	6	10285	36	PIK3CB,PRKCD,ADCY7,PLCG2,SYK,VAV3
1.354e-03	-6.60	Rho GTPase activation protein	gene3d domains	1.10.555.10	66	3	14470	48	ARHGAP27,GMIP,ARHGAP33
1.356e-03	-6.60	positive regulation of epithelial cell migration	biological process	GO:0010634	179	4	18204	49	HIF1A,PIK3CB,DOCK1,PLCG2
1.382e-03	-6.58	regulation of cellular component biogenesis	biological process	GO:0044087	1016	9	18204	49	PREX1,SYK,PRKCD,SEMA4A,PLCG2,TBC1D8,APOE,SKAP1,WAS
1.386e-03	-6.58	Nucleotide-like (purinergic) receptors	REACTOME pathways	R-HSA-418038	16	2	10285	36	P2RY2,P2RY6
1.398e-03	-6.57	granulocyte chemotaxis	biological process	GO:0071621	82	3	18204	49	VAV3,PREX1,SYK
1.398e-03	-6.57	T cell activation involved in immune response	biological process	GO:0002286	82	3	18204	49	CD74,SEMA4A,IL6R
1.407e-03	-6.57	WAS (WASP actin nucleation promoting factor)	protein interactions	7454	86	3	19454	50	FYB1,RGS14,WAS
1.423e-03	-6.56	superpathway of inositol phosphate compounds	BIOCYC pathways	HUMAN_PWY-6371	66	3	902	4	PIK3CB,PLCG2,PIK3R5
1.426e-03	-6.55	GPCR downstream signaling	REACTOME pathways	R-HSA-388396	974	10	10285	36	AKAP13,RGS14,ADCY7,PIK3CB,PRKCD,P2RY2,VAV3,PIK3R5,PREX1,P2RY6
1.442e-03	-6.54	regulation of cytokine-mediated signaling pathway	biological process	GO:0001959	182	4	18204	49	CD74,HIF1A,PTPN6,SYK
1.443e-03	-6.54	thymic T cell selection	biological process	GO:0045061	21	2	18204	49	CD74,DOCK2
1.443e-03	-6.54	prostanoid biosynthetic process	biological process	GO:0046457	21	2	18204	49	TBXAS1,CD74
1.443e-03	-6.54	positive regulation by host of viral process	biological process	GO:0044794	21	2	18204	49	CSF1R,APOE
1.443e-03	-6.54	regulation of superoxide anion generation	biological process	GO:0032928	21	2	18204	49	PRKCD,SYK
1.443e-03	-6.54	prostaglandin biosynthetic process	biological process	GO:0001516	21	2	18204	49	CD74,TBXAS1
1.448e-03	-6.54	positive regulation of B cell activation	biological process	GO:0050871	83	3	18204	49	VAV3,CD74,SYK
1.452e-03	-6.54	GDS_CDC24_CS	interpro domains	IPR001331	21	2	18521	50	VAV3,PREX1
1.455e-03	-6.53	PLCG2 (phospholipase C gamma 2)	protein interactions	5336	87	3	19454	50	PTPN6,SYK,PLCG2
1.494e-03	-6.51	negative regulation of phosphorylation	biological process	GO:0042326	313	5	18204	49	MICAL1,PTPN6,PRKCD,RGS14,APOE
1.531e-03	-6.48	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051897	185	4	18204	49	VAV3,CSF1R,PIK3R5,PTPN6
1.550e-03	-6.47	regulation of protein kinase activity	biological process	GO:0045859	469	6	18204	49	APOE,RGS14,PIK3R5,CSF1R,IL6R,PRKCD
1.556e-03	-6.47	plasma membrane signaling receptor complex	cellular component	GO:0098802	191	4	19108	50	SYK,SKAP1,IL6R,PTPN6
1.581e-03	-6.45	cytoskeleton organization	biological process	GO:0007010	1251	10	18204	49	WAS,ELMO1,RGS14,PARVG,APOE,MYO1F,MICAL1,NEK6,DOCK2,PREX1
1.598e-03	-6.44	regulation of transferase activity	biological process	GO:0051338	645	7	18204	49	PRKCD,CD74,CSF1R,IL6R,APOE,RGS14,PIK3R5
1.618e-03	-6.43	Signaling by PTK6	REACTOME pathways	R-HSA-8848021	67	3	10285	36	ELMO1,DOCK1,HIF1A
1.632e-03	-6.42	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	4	19454	50	SKAP1,IL6R,PIK3CB,MICAL1
1.639e-03	-6.41	guanyl-nucleotide exchange factor complex	cellular component	GO:0032045	23	2	19108	50	ELMO1,DOCK1
1.646e-03	-6.41	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	6	10285	36	PLCG2,PRKCD,PIK3CB,ADCY7,SYK,VAV3
1.650e-03	-6.41	MTOR (mechanistic target of rapamycin kinase)	protein interactions	2475	335	5	19454	50	PREX1,P2RY6,HIF1A,PRKCD,CD74
1.655e-03	-6.40	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	3	19454	50	PTPN6,PRKCD,CSF1R
1.656e-03	-6.40	B cell activation	biological process	GO:0042113	189	4	18204	49	PLCG2,DOCK10,SYK,PRKCD
1.656e-03	-6.40	regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001242	189	4	18204	49	PIK3CB,CD74,GSDME,HIF1A
1.656e-03	-6.40	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	37	16828	46	CSF1R,ADCY7,GIT2,DOCK2,MYO1F,PIK3CB,SLC4A2,PRKCD,RGS14,HIF1A,PIK3R5,DOCK1,VAV3,WAS,ELMO1,PTPN6,PLCG2,TBC1D8,NEK6,AKAP13,IL6R,RHBDF2,IRF5,PARVG,P2RY2,P2RY6,SYK,RIN3,GLIPR1,DOCK8,DENND1B,ARHGAP33,SEMA4A,DOCK10,WDFY4,SKAP1,PREX1
1.671e-03	-6.39	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	3	14470	48	AKAP13,VAV3,PREX1
1.677e-03	-6.39	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	37	16828	46	GLIPR1,RIN3,SYK,P2RY6,PARVG,P2RY2,IRF5,AKAP13,RHBDF2,IL6R,NEK6,TBC1D8,PREX1,WDFY4,SKAP1,ARHGAP33,DOCK10,SEMA4A,DOCK8,DENND1B,DOCK1,PIK3R5,HIF1A,RGS14,PRKCD,SLC4A2,DOCK2,GIT2,PIK3CB,MYO1F,ADCY7,CSF1R,PLCG2,ELMO1,PTPN6,WAS,VAV3
1.683e-03	-6.39	phospholipase binding	molecular function	GO:0043274	23	2	18094	48	WAS,SYK
1.684e-03	-6.39	Osteoclast differentiation	KEGG pathways	ko04380	129	4	7161	29	SYK,CSF1R,PLCG2,PIK3CB
1.684e-03	-6.39	Osteoclast differentiation	KEGG pathways	hsa04380	129	4	7161	29	PIK3CB,SYK,CSF1R,PLCG2
1.713e-03	-6.37	regulation of tissue remodeling	biological process	GO:0034103	88	3	18204	49	SYK,CSF1R,SLC4A2
1.713e-03	-6.37	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	7	19454	50	FYB1,SLC4A2,PREX1,DOCK8,RHBDF2,PRKCD,EHBP1L1
1.716e-03	-6.37	ERBB3 (erb-b2 receptor tyrosine kinase 3)	protein interactions	2065	338	5	19454	50	VAV3,PIK3CB,PLCG2,PTPN6,SYK
1.720e-03	-6.37	positive regulation of transport	biological process	GO:0051050	844	8	18204	49	HIF1A,APOE,P2RY6,PRKCD,SYK,DOCK2,PLCG2,P2RY2
1.723e-03	-6.36	FYB1 (FYN binding protein 1)	protein interactions	2533	24	2	19454	50	SKAP1,WAS
1.732e-03	-6.36	stimulatory C-type lectin receptor signaling pathway	biological process	GO:0002223	23	2	18204	49	SYK,PLCG2
1.732e-03	-6.36	response to lectin	biological process	GO:1990840	23	2	18204	49	PLCG2,SYK
1.732e-03	-6.36	phosphatidylinositol-mediated signaling	biological process	GO:0048015	23	2	18204	49	PLCG2,PIK3CB
1.732e-03	-6.36	cellular response to lectin	biological process	GO:1990858	23	2	18204	49	SYK,PLCG2
1.752e-03	-6.35	RHOGAP	prosite domains	PS50238	65	3	12186	45	GMIP,ARHGAP27,ARHGAP33
1.758e-03	-6.34	cell development	biological process	GO:0048468	2236	14	18204	49	SBNO2,PTPN6,DOCK10,SYK,SLC4A2,PLCG2,APOE,HIF1A,IL6R,CSF1R,DOCK2,SEMA4A,CD74,PREX1
1.759e-03	-6.34	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	7	16828	46	RIN3,SYK,PRKCD,RHBDF2,ADCY7,NEK6,CSF1R
1.759e-03	-6.34	Regulation of signaling by CBL	REACTOME pathways	R-HSA-912631	18	2	10285	36	SYK,PIK3CB
1.769e-03	-6.34	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	3	18204	49	CD74,APOE,PRKCD
1.822e-03	-6.31	regulation of response to cytokine stimulus	biological process	GO:0060759	194	4	18204	49	CD74,HIF1A,PTPN6,SYK
1.835e-03	-6.30	positive regulation of cell-cell adhesion	biological process	GO:0022409	328	5	18204	49	CD74,SYK,PTPN6,SKAP1,DOCK8
1.835e-03	-6.30	positive regulation of lymphocyte activation	biological process	GO:0051251	328	5	18204	49	CD74,SYK,PTPN6,VAV3,DOCK8
1.844e-03	-6.30	Rho_GTPase_activation_prot	interpro domains	IPR008936	90	3	18521	50	ARHGAP33,GMIP,ARHGAP27
1.854e-03	-6.29	VAV1 (vav guanine nucleotide exchange factor 1)	protein interactions	7409	204	4	19454	50	DOCK2,PTPN6,SYK,PLCG2
1.870e-03	-6.28	PIK3AP1 (phosphoinositide-3-kinase adaptor protein 1)	protein interactions	118788	25	2	19454	50	PLCG2,SYK
1.886e-03	-6.27	negative regulation of T cell apoptotic process	biological process	GO:0070233	24	2	18204	49	DOCK8,HIF1A
1.886e-03	-6.27	positive regulation of macrophage cytokine production	biological process	GO:0060907	24	2	18204	49	PLCG2,CD74
1.913e-03	-6.26	human chr7p14.2-p14.1	chromosome location	human chr7p14.2-p14.1	1	1	26134	50	ELMO1
1.923e-03	-6.25	phosphoprotein binding	molecular function	GO:0051219	93	3	18094	48	PLCG2,SYK,PTPN6
1.945e-03	-6.24	positive regulation of leukocyte chemotaxis	biological process	GO:0002690	92	3	18204	49	CSF1R,IL6R,CD74
1.999e-03	-6.22	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	4	18204	49	CSF1R,P2RY6,APOE,CD74
2.047e-03	-6.19	PTK2B (protein tyrosine kinase 2 beta)	protein interactions	2185	98	3	19454	50	PRKCD,PTPN6,SYK
2.056e-03	-6.19	Factors involved in megakaryocyte development and platelet production	REACTOME pathways	R-HSA-983231	156	4	10285	36	DOCK1,DOCK10,DOCK8,DOCK2
2.069e-03	-6.18	negative regulation of protein serine/threonine kinase activity	biological process	GO:0071901	94	3	18204	49	RGS14,APOE,PRKCD
2.103e-03	-6.16	RhoGAP	smart domains	SM00324	64	3	9717	39	ARHGAP27,ARHGAP33,GMIP
2.108e-03	-6.16	Shigellosis	KEGG pathways	hsa05131	64	3	7161	29	DOCK1,WAS,ELMO1
2.133e-03	-6.15	endocytic vesicle	cellular component	GO:0030139	349	5	19108	50	CD74,SYK,APOE,RIN3,WAS
2.149e-03	-6.14	negative regulation of cell-cell adhesion	biological process	GO:0022408	203	4	18204	49	SLC4A2,PTPN6,PRKCD,CD74
2.167e-03	-6.13	DH_2	prosite domains	PS50010	70	3	12186	45	VAV3,AKAP13,PREX1
2.181e-03	-6.13	CD72 (CD72 molecule)	protein interactions	971	27	2	19454	50	PTPN6,SYK
2.181e-03	-6.13	CD19 (CD19 molecule)	protein interactions	930	27	2	19454	50	PLCG2,SYK
2.185e-03	-6.13	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	7	19454	50	PRKCD,SKAP1,SYK,CSF1R,PLCG2,PTPN6,TBC1D8
2.197e-03	-6.12	granulocyte migration	biological process	GO:0097530	96	3	18204	49	PREX1,SYK,VAV3
2.197e-03	-6.12	negative regulation of response to wounding	biological process	GO:1903035	96	3	18204	49	PTPN6,PRKCD,APOE
2.201e-03	-6.12	angiogenesis	biological process	GO:0001525	342	5	18204	49	VAV3,PIK3CB,SYK,SEMA4A,HIF1A
2.202e-03	-6.12	anchoring junction	cellular component	GO:0070161	902	8	19108	50	GIT2,FYB1,WAS,PTPN6,PARVG,SLC4A2,SKAP1,PRKCD
2.217e-03	-6.11	ATG16L1 (autophagy related 16 like 1)	protein interactions	55054	1138	9	19454	50	PLCG2,GIT2,DOCK2,SYK,GMIP,AKAP13,ELMO1,WAS,MICAL1
2.249e-03	-6.10	tube morphogenesis	biological process	GO:0035239	685	7	18204	49	SYK,SEMA4A,PIK3CB,APOE,HIF1A,CSF1R,VAV3
2.250e-03	-6.10	regulation of lymphocyte activation	biological process	GO:0051249	505	6	18204	49	SYK,PTPN6,CD74,DOCK8,SLC4A2,VAV3
2.286e-03	-6.08	CRK (CRK proto-oncogene, adaptor protein)	protein interactions	1398	361	5	19454	50	DOCK1,ELMO1,RIN3,PIK3CB,MICAL1
2.294e-03	-6.08	GRAP2 (GRB2 related adaptor protein 2)	protein interactions	9402	102	3	19454	50	CSF1R,SYK,RIN3
2.314e-03	-6.07	PSMD3 (proteasome 26S subunit, non-ATPase 3)	protein interactions	5709	362	5	19454	50	RIN3,PTPN6,P2RY6,CD74,PLCG2
2.324e-03	-6.06	Cell death signalling via NRAGE, NRIF and NADE	REACTOME pathways	R-HSA-204998	76	3	10285	36	VAV3,PREX1,AKAP13
2.344e-03	-6.06	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	13	16828	46	PLCG2,PTPN6,WAS,VAV3,DOCK8,RIN3,PIK3R5,SYK,P2RY6,PRKCD,P2RY2,PIK3CB,CSF1R
2.344e-03	-6.06	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	13	16828	46	CSF1R,PIK3CB,SYK,P2RY6,PRKCD,P2RY2,PIK3R5,RIN3,DOCK8,VAV3,PTPN6,WAS,PLCG2
2.387e-03	-6.04	positive regulation of receptor internalization	biological process	GO:0002092	27	2	18204	49	PLCG2,SYK
2.387e-03	-6.04	mature B cell differentiation involved in immune response	biological process	GO:0002313	27	2	18204	49	PLCG2,DOCK10
2.387e-03	-6.04	cytokine production	biological process	GO:0001816	27	2	18204	49	HIF1A,IL6R
2.388e-03	-6.04	regulation of chemotaxis	biological process	GO:0050920	209	4	18204	49	RIN3,CD74,IL6R,CSF1R
2.424e-03	-6.02	GRK2 (G protein-coupled receptor kinase 2)	protein interactions	156	104	3	19454	50	PIK3CB,PRKCD,GIT2
2.482e-03	-6.00	monoatomic ion homeostasis	biological process	GO:0050801	515	6	18204	49	HIF1A,APOE,PIK3CB,TBXAS1,SLC4A2,P2RY2
2.502e-03	-5.99	RhoGEF	smart domains	SM00325	68	3	9717	39	VAV3,AKAP13,PREX1
2.514e-03	-5.99	CNTF (ciliary neurotrophic factor)	protein interactions	1270	29	2	19454	50	IL6R,APOE
2.520e-03	-5.98	PDGFRB (platelet derived growth factor receptor beta)	protein interactions	5159	222	4	19454	50	CSF1R,PTPN6,HIF1A,VAV3
2.566e-03	-5.97	purinergic nucleotide receptor signaling pathway	biological process	GO:0035590	28	2	18204	49	P2RY6,P2RY2
2.570e-03	-5.96	Prkch (protein kinase C, eta)	protein interactions	81749	1	1	19454	50	AKAP13
2.570e-03	-5.96	Pstpip1 (proline-serine-threonine phosphatase-interacting protein 1)	protein interactions	19200	1	1	19454	50	WAS
2.570e-03	-5.96	ARP3 (actin-related protein 3)	protein interactions	853528	1	1	19454	50	WAS
2.570e-03	-5.96	Bmal1 (basic helix-loop-helix ARNT like 1)	protein interactions	11865	1	1	19454	50	HIF1A
2.570e-03	-5.96	ARC40 (Arc40p)	protein interactions	852536	1	1	19454	50	WAS
2.570e-03	-5.96	EUC1 (Euc1p)	protein interactions	855138	1	1	19454	50	DOCK8
2.570e-03	-5.96	NTA1 (amidase)	protein interactions	853525	1	1	19454	50	DOCK8
2.570e-03	-5.96	FDPSP4 (farnesyl diphosphate synthase pseudogene 4)	protein interactions	2228	1	1	19454	50	RIN3
2.570e-03	-5.96	RPL26P32 (ribosomal protein L26 pseudogene 32)	protein interactions	400055	1	1	19454	50	RIN3
2.604e-03	-5.95	phosphatidylinositol 3-kinase complex	cellular component	GO:0005942	29	2	19108	50	PIK3R5,PIK3CB
2.610e-03	-5.95	regulation of phagocytosis	biological process	GO:0050764	102	3	18204	49	PLCG2,DOCK2,SYK
2.617e-03	-5.95	NOS2-CD74 complex	cellular component	GO:0035693	1	1	19108	50	CD74
2.628e-03	-5.94	RPL39 (ribosomal protein L39)	protein interactions	6170	107	3	19454	50	SYK,PTPN6,P2RY6
2.628e-03	-5.94	TPP2 (tripeptidyl peptidase 2)	protein interactions	7174	107	3	19454	50	P2RY6,CD74,RIN3
2.645e-03	-5.93	JPH1 (junctophilin 1)	protein interactions	56704	225	4	19454	50	CSF1R,SKAP1,RHBDF2,TBC1D8
2.653e-03	-5.93	MHC class II protein binding, via antigen binding groove	molecular function	GO:0042658	1	1	18094	48	CD74
2.653e-03	-5.93	ciliary neurotrophic factor binding	molecular function	GO:0070119	1	1	18094	48	IL6R
2.653e-03	-5.93	interleukin-15 receptor binding	molecular function	GO:0016170	1	1	18094	48	SYK
2.653e-03	-5.93	metal chelating activity	molecular function	GO:0046911	1	1	18094	48	APOE
2.675e-03	-5.92	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	19	16828	46	VAV3,SEMA4A,ARHGAP33,PTPN6,PREX1,PLCG2,NEK6,CSF1R,IRF5,PIK3CB,GIT2,IL6R,AKAP13,SYK,PRKCD,RGS14,DOCK1,PIK3R5,HIF1A
2.678e-03	-5.92	DH_1	prosite domains	PS00741	21	2	12186	45	PREX1,VAV3
2.688e-03	-5.92	PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)	protein interactions	5296	226	4	19454	50	PIK3CB,SYK,SKAP1,CSF1R
2.690e-03	-5.92	CSF3R (colony stimulating factor 3 receptor)	protein interactions	1441	30	2	19454	50	SYK,PRKCD
2.690e-03	-5.92	regulation of lymphocyte differentiation	biological process	GO:0045619	216	4	18204	49	PTPN6,SYK,CD74,SLC4A2
2.692e-03	-5.92	memory T cell proliferation	biological process	GO:0061485	1	1	18204	49	DOCK8
2.692e-03	-5.92	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of T cell antigen processing and presentation	biological process	GO:0002625	1	1	18204	49	WAS
2.692e-03	-5.92	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	49	APOE
2.692e-03	-5.92	cellular response to pyrimidine ribonucleotide	biological process	GO:1905835	1	1	18204	49	P2RY6
2.692e-03	-5.92	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of phospholipid scramblase activity	biological process	GO:1900163	1	1	18204	49	PRKCD
2.692e-03	-5.92	negative regulation of mast cell chemotaxis	biological process	GO:0060755	1	1	18204	49	RIN3
2.692e-03	-5.92	regulation of phospholipid scramblase activity	biological process	GO:1900161	1	1	18204	49	PRKCD
2.692e-03	-5.92	response to pyrimidine ribonucleotide	biological process	GO:1905834	1	1	18204	49	P2RY6
2.692e-03	-5.92	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of glucosylceramide catabolic process	biological process	GO:2000753	1	1	18204	49	PRKCD
2.692e-03	-5.92	cellular response to interleukin-11	biological process	GO:0071348	1	1	18204	49	SBNO2
2.692e-03	-5.92	positive regulation of interleukin-3 production	biological process	GO:0032752	1	1	18204	49	SYK
2.692e-03	-5.92	zygote asymmetric cell division	biological process	GO:0010070	1	1	18204	49	RGS14
2.692e-03	-5.92	macrophage migration inhibitory factor signaling pathway	biological process	GO:0035691	1	1	18204	49	CD74
2.692e-03	-5.92	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	49	APOE
2.700e-03	-5.91	TBC1D8_PH-GRAM2	interpro domains	IPR036016	1	1	18521	50	TBC1D8
2.700e-03	-5.91	CSF-1_receptor	interpro domains	IPR030658	1	1	18521	50	CSF1R
2.700e-03	-5.91	MHCII_invariant_trimer_sf	interpro domains	IPR036613	1	1	18521	50	CD74
2.700e-03	-5.91	PKC_delta	interpro domains	IPR027436	1	1	18521	50	PRKCD
2.700e-03	-5.91	RBD2_RGS14	interpro domains	IPR046993	1	1	18521	50	RGS14
2.700e-03	-5.91	DHR2_DOCK2	interpro domains	IPR026799	1	1	18521	50	DOCK2
2.700e-03	-5.91	FYB_hSH3	interpro domains	IPR035540	1	1	18521	50	FYB1
2.700e-03	-5.91	MHC_II-assoc_invar/CLIP_MHC-bd	interpro domains	IPR015386	1	1	18521	50	CD74
2.700e-03	-5.91	nPKC_delta	interpro domains	IPR034667	1	1	18521	50	PRKCD
2.700e-03	-5.91	PLCgamma2_SH3	interpro domains	IPR035723	1	1	18521	50	PLCG2
2.700e-03	-5.91	RIN3_SH2	interpro domains	IPR035869	1	1	18521	50	RIN3
2.700e-03	-5.91	DOCK1_C2	interpro domains	IPR047026	1	1	18521	50	DOCK1
2.700e-03	-5.91	VAV3_SH3_2	interpro domains	IPR035734	1	1	18521	50	VAV3
2.700e-03	-5.91	CD74_antigen	interpro domains	IPR043530	1	1	18521	50	CD74
2.700e-03	-5.91	MHC_II-assoc_invariant_trimer	interpro domains	IPR011988	1	1	18521	50	CD74
2.700e-03	-5.91	P2Y6_rcpt	interpro domains	IPR001973	1	1	18521	50	P2RY6
2.700e-03	-5.91	MHC_II-assoc_invar_chain	interpro domains	IPR022339	1	1	18521	50	CD74
2.700e-03	-5.91	P2Y2_rcpt	interpro domains	IPR000356	1	1	18521	50	P2RY2
2.700e-03	-5.91	RBD1_RGS14	interpro domains	IPR046992	1	1	18521	50	RGS14
2.700e-03	-5.91	SKAP1_SH3	interpro domains	IPR035765	1	1	18521	50	SKAP1
2.700e-03	-5.91	VAV3_SH3_1	interpro domains	IPR047015	1	1	18521	50	VAV3
2.700e-03	-5.91	PI3Kbeta_dom	interpro domains	IPR037702	1	1	18521	50	PIK3CB
2.700e-03	-5.91	TBC1D8_PH-GRAM1	interpro domains	IPR036009	1	1	18521	50	TBC1D8
2.700e-03	-5.91	VAV3_SH2	interpro domains	IPR035881	1	1	18521	50	VAV3
2.700e-03	-5.91	Anion_exchange_2	interpro domains	IPR002978	1	1	18521	50	SLC4A2
2.700e-03	-5.91	HIF-1_alpha	interpro domains	IPR001321	1	1	18521	50	HIF1A
2.700e-03	-5.91	RGS14_RGS	interpro domains	IPR037881	1	1	18521	50	RGS14
2.721e-03	-5.91	seminoma	COSMIC cancer mutations	seminoma	700	7	16828	46	RHBDF2,ADCY7,NEK6,CSF1R,RIN3,SYK,PRKCD
2.730e-03	-5.90	Kinase-like_dom_sf	interpro domains	IPR011009	523	6	18521	50	PIK3CB,PRKCD,CSF1R,SYK,NEK6,NRK
2.731e-03	-5.90	PRKCD (protein kinase C delta)	protein interactions	5580	227	4	19454	50	PTPN6,ADCY7,PRKCD,PIK3CB
2.735e-03	-5.90	positive regulation of cellular catabolic process	biological process	GO:0031331	217	4	18204	49	PRKCD,PIK3CB,HIF1A,APOE
2.751e-03	-5.90	cellular response to interleukin-6	biological process	GO:0071354	29	2	18204	49	IL6R,SBNO2
2.751e-03	-5.90	regulation of platelet aggregation	biological process	GO:0090330	29	2	18204	49	SYK,PRKCD
2.751e-03	-5.90	myoblast fusion	biological process	GO:0007520	29	2	18204	49	DOCK1,DOCK2
2.810e-03	-5.87	MHCassoc_trimer	pfam domains	PF08831	1	1	17795	50	CD74
2.810e-03	-5.87	MHC2-interact	pfam domains	PF09307	1	1	17795	50	CD74
2.814e-03	-5.87	positive regulation of leukocyte activation	biological process	GO:0002696	362	5	18204	49	SYK,PTPN6,CD74,DOCK8,VAV3
2.819e-03	-5.87	PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)	protein interactions	5110	229	4	19454	50	RIN3,AKAP13,APOE,DOCK8
2.836e-03	-5.87	negative regulation of immune system process	biological process	GO:0002683	529	6	18204	49	SLC4A2,CD74,RHBDF2,PTPN6,RIN3,SYK
2.844e-03	-5.86	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	31	16828	46	ELMO1,VAV3,PIK3R5,DOCK1,HIF1A,PRKCD,SLC4A2,GIT2,DOCK2,MYO1F,PIK3CB,ADCY7,CSF1R,IPCEF1,PREX1,ARHGAP27,WDFY4,GMIP,SKAP1,ARHGAP33,DOCK10,SBNO2,DOCK8,DENND1B,RIN3,APOE,SYK,PARVG,AKAP13,NEK6,TBC1D8
2.862e-03	-5.86	blood vessel development	biological process	GO:0001568	530	6	18204	49	VAV3,PIK3CB,HIF1A,APOE,SEMA4A,SYK
2.870e-03	-5.85	CSF2RB (colony stimulating factor 2 receptor subunit beta)	protein interactions	1439	31	2	19454	50	SYK,PTPN6
2.916e-03	-5.84	response to oxidative stress	biological process	GO:0006979	365	5	18204	49	APOE,HIF1A,RGS14,PRKCD,IPCEF1
2.921e-03	-5.84	regulation of cell-substrate adhesion	biological process	GO:0010810	221	4	18204	49	PIK3CB,DOCK1,PREX1,SKAP1
2.921e-03	-5.84	leukocyte mediated immunity	biological process	GO:0002443	221	4	18204	49	PRKCD,SYK,PTPN6,CD74
2.942e-03	-5.83	regulation of superoxide metabolic process	biological process	GO:0090322	30	2	18204	49	PRKCD,SYK
2.956e-03	-5.82	P2YPURNOCPTR	prints domains	PR01157	24	2	5227	18	P2RY6,P2RY2
3.057e-03	-5.79	AAMDC (adipogenesis associated Mth938 domain containing)	protein interactions	28971	32	2	19454	50	VAV3,GMIP
3.067e-03	-5.79	LAT (linker for activation of T cells)	protein interactions	27040	113	3	19454	50	SYK,PTPN6,PLCG2
3.113e-03	-5.77	cell population proliferation	biological process	GO:0008283	726	7	18204	49	DOCK8,DOCK2,PTPN6,PRKCD,CSF1R,HIF1A,PIK3CB
3.140e-03	-5.76	B cell homeostasis	biological process	GO:0001782	31	2	18204	49	DOCK10,HIF1A
3.185e-03	-5.75	phosphorylation	biological process	GO:0016310	729	7	18204	49	CSF1R,PIK3CB,NRK,SYK,PRKCD,NEK6,PTPN6
3.186e-03	-5.75	positive regulation of cellular biosynthetic process	biological process	GO:0031328	2652	15	18204	49	WAS,SKAP1,SBNO2,P2RY6,DENND1B,IRF5,PLCG2,SYK,IL6R,CSF1R,PIK3CB,APOE,HIF1A,PRKCD,CD74
3.191e-03	-5.75	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	15	16828	46	IPCEF1,PTPN6,ELMO1,WDFY4,SKAP1,SBNO2,MICAL1,DOCK8,RIN3,DOCK1,SLC4A2,RGS14,ADCY7,DOCK2,CSF1R
3.249e-03	-5.73	ELMO3 (engulfment and cell motility 3)	protein interactions	79767	33	2	19454	50	ELMO1,DOCK1
3.286e-03	-5.72	SH3_1	pfam domains	PF00018	106	3	17795	50	PLCG2,DOCK1,MYO1F
3.317e-03	-5.71	MHC class II-associated invariant chain, trimerisation domain	gene3d domains	1.10.870.10	1	1	14470	48	CD74
3.335e-03	-5.70	SLC1A5 (solute carrier family 1 member 5)	protein interactions	6510	240	4	19454	50	RIN3,RHBDF2,P2RY6,NEK6
3.349e-03	-5.70	negative regulation of phosphate metabolic process	biological process	GO:0045936	377	5	18204	49	MICAL1,PRKCD,PTPN6,APOE,RGS14
3.367e-03	-5.69	PRKCA (protein kinase C alpha)	protein interactions	5578	395	5	19454	50	AKAP13,SYK,PTPN6,PLCG2,PRKCD
3.387e-03	-5.69	negative regulation of phosphorus metabolic process	biological process	GO:0010563	378	5	18204	49	PTPN6,PRKCD,RGS14,APOE,MICAL1
3.401e-03	-5.68	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	5	18521	50	PRKCD,SYK,NEK6,NRK,CSF1R
3.406e-03	-5.68	localization within membrane	biological process	GO:0051668	549	6	18204	49	DENND1B,RHBDF2,DOCK2,SKAP1,FYB1,APOE
3.436e-03	-5.67	vasculature development	biological process	GO:0001944	550	6	18204	49	SEMA4A,SYK,VAV3,PIK3CB,APOE,HIF1A
3.444e-03	-5.67	ANIONEXHNGR2	prints domains	PR01188	1	1	5227	18	SLC4A2
3.444e-03	-5.67	P2Y2PRNOCPTR	prints domains	PR00594	1	1	5227	18	P2RY2
3.444e-03	-5.67	CD74ANTIGEN	prints domains	PR01990	1	1	5227	18	CD74
3.444e-03	-5.67	P2Y6PRNOCPTR	prints domains	PR01068	1	1	5227	18	P2RY6
3.444e-03	-5.67	HYPOXIAIF1A	prints domains	PR01080	1	1	5227	18	HIF1A
3.446e-03	-5.67	ELMO1 (engulfment and cell motility 1)	protein interactions	9844	34	2	19454	50	DOCK2,DOCK1
3.486e-03	-5.66	innate immune response	biological process	GO:0045087	741	7	18204	49	CSF1R,WAS,CD74,PTPN6,SYK,PLCG2,IRF5
3.486e-03	-5.66	negative regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001243	113	3	18204	49	PIK3CB,CD74,HIF1A
3.492e-03	-5.66	negative regulation of programmed cell death	biological process	GO:0043069	946	8	18204	49	MICAL1,PLCG2,DOCK8,CD74,PRKCD,CSF1R,HIF1A,PIK3CB
3.504e-03	-5.65	positive regulation of cell activation	biological process	GO:0050867	381	5	18204	49	VAV3,DOCK8,CD74,PTPN6,SYK
3.516e-03	-5.65	testis	COSMIC cancer mutations	testis	733	7	16828	46	RHBDF2,ADCY7,CSF1R,NEK6,RIN3,PRKCD,SYK
3.524e-03	-5.65	G alpha (12/13) signalling events	REACTOME pathways	R-HSA-416482	88	3	10285	36	VAV3,AKAP13,PREX1
3.553e-03	-5.64	mature B cell differentiation	biological process	GO:0002335	33	2	18204	49	PLCG2,DOCK10
3.553e-03	-5.64	negative regulation of inflammatory response to antigenic stimulus	biological process	GO:0002862	33	2	18204	49	RHBDF2,SYK
3.574e-03	-5.63	icosanoid metabolic process	biological process	GO:0006690	114	3	18204	49	TBXAS1,CD74,SYK
3.623e-03	-5.62	regulation of T cell activation	biological process	GO:0050863	384	5	18204	49	DOCK8,SLC4A2,PTPN6,SYK,CD74
3.649e-03	-5.61	IL2RB (interleukin 2 receptor subunit beta)	protein interactions	3560	35	2	19454	50	PTPN6,SYK
3.677e-03	-5.61	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	739	7	16828	46	MICAL1,CSF1R,PIK3CB,DOCK2,PTPN6,PLCG2,DOCK1
3.677e-03	-5.61	acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_T_cell_leukaemia	739	7	16828	46	PIK3CB,DOCK1,DOCK2,PLCG2,MICAL1,PTPN6,CSF1R
3.694e-03	-5.60	regulation of endothelial cell migration	biological process	GO:0010594	236	4	18204	49	APOE,HIF1A,PIK3CB,SEMA4A
3.751e-03	-5.59	regulation of lymphocyte proliferation	biological process	GO:0050670	237	4	18204	49	CD74,PTPN6,VAV3,SLC4A2
3.756e-03	-5.58	positive regulation of biosynthetic process	biological process	GO:0009891	2697	15	18204	49	SBNO2,SKAP1,WAS,P2RY6,PLCG2,IRF5,DENND1B,SYK,CSF1R,IL6R,APOE,HIF1A,PIK3CB,CD74,PRKCD
3.769e-03	-5.58	response to interleukin-6	biological process	GO:0070741	34	2	18204	49	SBNO2,IL6R
3.769e-03	-5.58	regulation of B cell differentiation	biological process	GO:0045577	34	2	18204	49	PTPN6,SYK
3.769e-03	-5.58	regulation of type 2 immune response	biological process	GO:0002828	34	2	18204	49	DENND1B,CD74
3.841e-03	-5.56	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	hsa01521	79	3	7161	29	PIK3CB,IL6R,PLCG2
3.841e-03	-5.56	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	ko01521	79	3	7161	29	PIK3CB,IL6R,PLCG2
3.887e-03	-5.55	cell junction	cellular component	GO:0030054	2224	13	19108	50	RGS14,WAS,PTPN6,APOE,ARHGAP33,PARVG,DOCK10,MICAL1,SKAP1,PRKCD,GIT2,FYB1,SLC4A2
3.917e-03	-5.54	Cytokine Signaling in Immune system	REACTOME pathways	R-HSA-1280215	756	8	10285	36	SYK,CSF1R,IRF5,IL6R,PTPN6,PRKCD,HIF1A,PIK3CB
3.957e-03	-5.53	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	REACTOME pathways	R-HSA-8849471	27	2	10285	36	ELMO1,DOCK1
4.031e-03	-5.51	protein kinase activity	molecular function	GO:0004672	577	6	18094	48	NEK6,PRKCD,PIK3CB,CSF1R,NRK,SYK
4.036e-03	-5.51	membrane organization	biological process	GO:0061024	761	7	18204	49	ELMO1,VAV3,APOE,PRKCD,DOCK1,NEK6,DOCK2
4.040e-03	-5.51	regulation of mononuclear cell proliferation	biological process	GO:0032944	242	4	18204	49	CD74,PTPN6,SLC4A2,VAV3
4.065e-03	-5.51	positive regulation of protein modification process	biological process	GO:0031401	762	7	18204	49	PLCG2,PRKCD,SYK,CD74,CSF1R,IL6R,PIK3R5
4.071e-03	-5.50	CD22 (CD22 molecule)	protein interactions	933	37	2	19454	50	SYK,PTPN6
4.071e-03	-5.50	CARD11 (caspase recruitment domain family member 11)	protein interactions	84433	37	2	19454	50	FYB1,PRKCD
4.128e-03	-5.49	regulation of apoptotic signaling pathway	biological process	GO:2001233	396	5	18204	49	HIF1A,CD74,GSDME,PRKCD,PIK3CB
4.163e-03	-5.48	regulation of leukocyte activation	biological process	GO:0002694	572	6	18204	49	PTPN6,SYK,CD74,DOCK8,VAV3,SLC4A2
4.165e-03	-5.48	UQCRH (ubiquinol-cytochrome c reductase hinge protein)	protein interactions	7388	126	3	19454	50	GSDME,P2RY6,APOE
4.218e-03	-5.47	regulation of homotypic cell-cell adhesion	biological process	GO:0034110	36	2	18204	49	PRKCD,SYK
4.218e-03	-5.47	phagocytosis, engulfment	biological process	GO:0006911	36	2	18204	49	ELMO1,DOCK1
4.229e-03	-5.47	regulation of response to stress	biological process	GO:0080134	1431	10	18204	49	PLCG2,RHBDF2,CD74,SYK,PRKCD,PTPN6,SBNO2,WAS,APOE,PIK3CB
4.229e-03	-5.47	defense response	biological process	GO:0006952	1431	10	18204	49	WAS,CSF1R,IL6R,HIF1A,IRF5,PLCG2,PRKCD,SYK,PTPN6,CD74
4.244e-03	-5.46	Interferon gamma signaling	REACTOME pathways	R-HSA-877300	94	3	10285	36	PRKCD,PTPN6,IRF5
4.252e-03	-5.46	Calmodulin induced events	REACTOME pathways	R-HSA-111933	28	2	10285	36	PRKCD,ADCY7
4.252e-03	-5.46	Dectin-2 family	REACTOME pathways	R-HSA-5621480	28	2	10285	36	SYK,PLCG2
4.252e-03	-5.46	CaM pathway	REACTOME pathways	R-HSA-111997	28	2	10285	36	ADCY7,PRKCD
4.280e-03	-5.45	3-phosphoinositide biosynthesis	BIOCYC pathways	META_PWY-6352	25	2	902	4	PIK3CB,PIK3R5
4.324e-03	-5.44	intracellular vesicle	cellular component	GO:0097708	2527	14	19108	50	APOE,WAS,PTPN6,CD74,PLCG2,SYK,DOCK2,PRKCD,MICAL1,WDFY4,GLIPR1,DENND1B,EHBP1L1,RIN3
4.352e-03	-5.44	BTK (Bruton tyrosine kinase)	protein interactions	695	128	3	19454	50	WAS,PLCG2,SYK
4.382e-03	-5.43	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	7	16828	46	CSF1R,NEK6,GMIP,WDFY4,PIK3CB,SYK,PRKCD
4.382e-03	-5.43	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	7	16828	46	PRKCD,SYK,CSF1R,NEK6,GMIP,WDFY4,PIK3CB
4.433e-03	-5.42	PTPN6 (protein tyrosine phosphatase non-receptor type 6)	protein interactions	5777	260	4	19454	50	SYK,PTPN6,PLCG2,PRKCD
4.451e-03	-5.41	regulation of macrophage cytokine production	biological process	GO:0010935	37	2	18204	49	CD74,PLCG2
4.452e-03	-5.41	pleura-mesothelioma	COSMIC cancer mutations	pleura-mesothelioma	4189	20	16828	46	VAV3,SEMA4A,ARHGAP33,PREX1,PLCG2,PTPN6,WAS,PIK3CB,IRF5,GIT2,IL6R,AKAP13,NEK6,CSF1R,DOCK1,PIK3R5,HIF1A,PRKCD,SYK,RGS14
4.491e-03	-5.41	intracellular chemical homeostasis	biological process	GO:0055082	581	6	18204	49	TBXAS1,SLC4A2,P2RY2,PIK3CB,APOE,HIF1A
4.523e-03	-5.40	positive regulation of lipid metabolic process	biological process	GO:0045834	124	3	18204	49	CD74,APOE,PRKCD
4.523e-03	-5.40	positive regulation of cell-substrate adhesion	biological process	GO:0010811	124	3	18204	49	DOCK1,PREX1,SKAP1
4.557e-03	-5.39	The role of Nef in HIV-1 replication and disease pathogenesis	REACTOME pathways	R-HSA-164952	29	2	10285	36	DOCK2,ELMO1
4.564e-03	-5.39	positive regulation of gene expression	biological process	GO:0010628	1212	9	18204	49	SYK,CD74,DENND1B,PLCG2,IRF5,PIK3CB,HIF1A,IL6R,CSF1R
4.634e-03	-5.37	p75 NTR receptor-mediated signalling	REACTOME pathways	R-HSA-193704	97	3	10285	36	PREX1,AKAP13,VAV3
4.655e-03	-5.37	positive regulation of cell population proliferation	biological process	GO:0008284	992	8	18204	49	VAV3,CSF1R,IL6R,HIF1A,TBC1D8,P2RY6,CD74,PTPN6
4.691e-03	-5.36	actin filament polymerization	biological process	GO:0030041	38	2	18204	49	WAS,PREX1
4.691e-03	-5.36	unsaturated fatty acid biosynthetic process	biological process	GO:0006636	38	2	18204	49	CD74,TBXAS1
4.730e-03	-5.35	regulation of type I interferon production	biological process	GO:0032479	126	3	18204	49	IRF5,PLCG2,SYK
4.744e-03	-5.35	FLRT1 (fibronectin leucine rich transmembrane protein 1)	protein interactions	23769	40	2	19454	50	PIK3CB,RHBDF2
4.777e-03	-5.34	ACTG1 (actin gamma 1)	protein interactions	71	429	5	19454	50	APOE,GIT2,ARHGAP27,GSDME,RIN3
4.843e-03	-5.33	PLD2 (phospholipase D2)	protein interactions	5338	133	3	19454	50	SKAP1,PRKCD,HIF1A
4.852e-03	-5.33	cellular process	biological process	GO:0009987	14996	47	18204	49	RGS14,APOE,MYO1F,PREX1,SKAP1,NRK,IRF5,PTPN6,CSF1R,IL6R,ARHGAP33,AKAP13,CD74,GMIP,SBNO2,TBXAS1,P2RY6,SLC4A2,IPCEF1,GIT2,NEK6,CARMIL3,SYK,ELMO1,PARVG,RIN3,PIK3CB,DOCK2,PRKCD,WAS,MICAL1,DOCK10,HIF1A,P2RY2,ARHGAP27,WDFY4,DOCK8,ADCY7,RHBDF2,SEMA4A,VAV3,FYB1,PIK3R5,PLCG2,DENND1B,GSDME,DOCK1
4.861e-03	-5.33	positive regulation of T cell activation	biological process	GO:0050870	255	4	18204	49	PTPN6,SYK,CD74,DOCK8
4.872e-03	-5.32	Ca-dependent events	REACTOME pathways	R-HSA-111996	30	2	10285	36	ADCY7,PRKCD
4.897e-03	-5.32	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	21	16828	46	PIK3R5,DOCK1,HIF1A,SYK,RGS14,PRKCD,GIT2,DOCK2,PIK3CB,IRF5,AKAP13,IL6R,CSF1R,NEK6,PREX1,PLCG2,PTPN6,WAS,VAV3,ARHGAP33,SEMA4A
4.897e-03	-5.32	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	21	16828	46	SYK,RGS14,PRKCD,PIK3R5,DOCK1,HIF1A,NEK6,CSF1R,IRF5,PIK3CB,GIT2,DOCK2,IL6R,AKAP13,PTPN6,WAS,PREX1,PLCG2,VAV3,SEMA4A,ARHGAP33
4.911e-03	-5.32	anatomical structure morphogenesis	biological process	GO:0009653	2225	13	18204	49	CSF1R,PIK3CB,APOE,HIF1A,SEMA4A,DOCK2,SBNO2,VAV3,SLC4A2,SYK,DOCK10,PTPN6,DOCK1
4.929e-03	-5.31	positive regulation of protein kinase activity	biological process	GO:0045860	256	4	18204	49	IL6R,CSF1R,PIK3R5,PRKCD
4.936e-03	-5.31	long-term memory	biological process	GO:0007616	39	2	18204	49	APOE,RGS14
4.936e-03	-5.31	regulation of T cell apoptotic process	biological process	GO:0070232	39	2	18204	49	HIF1A,DOCK8
4.936e-03	-5.31	positive regulation of nitric oxide biosynthetic process	biological process	GO:0045429	39	2	18204	49	PIK3CB,APOE
4.980e-03	-5.30	HCLS1 (hematopoietic cell-specific Lyn substrate 1)	protein interactions	3059	41	2	19454	50	WAS,SYK
4.993e-03	-5.30	3-phosphoinositide biosynthesis	BIOCYC pathways	HUMAN_PWY-6352	27	2	902	4	PIK3CB,PIK3R5
5.015e-03	-5.30	Type II diabetes mellitus	WikiPathways	WP1584	22	2	5310	26	PIK3R5,PRKCD
5.134e-03	-5.27	Rab5b (RAB5B, member RAS oncogene family)	protein interactions	288779	2	1	19454	50	PIK3CB
5.134e-03	-5.27	ARPC3 (actin related protein 2/3 complex subunit 3)	protein interactions	506596	2	1	19454	50	WAS
5.134e-03	-5.27	ARPC2 (actin related protein 2/3 complex subunit 2)	protein interactions	540838	2	1	19454	50	WAS
5.134e-03	-5.27	ACTR3 (actin related protein 3)	protein interactions	281597	2	1	19454	50	WAS
5.134e-03	-5.27	ACTR2 (actin related protein 2)	protein interactions	538486	2	1	19454	50	WAS
5.134e-03	-5.27	KIR2DL5A (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A)	protein interactions	57292	2	1	19454	50	PTPN6
5.134e-03	-5.27	Per1 (period circadian clock 1)	protein interactions	18626	2	1	19454	50	HIF1A
5.134e-03	-5.27	Arnt (aryl hydrocarbon receptor nuclear translocator)	protein interactions	11863	2	1	19454	50	HIF1A
5.134e-03	-5.27	MPIG6B (megakaryocyte and platelet inhibitory receptor G6b)	protein interactions	80739	2	1	19454	50	PTPN6
5.134e-03	-5.27	Siglece (sialic acid binding Ig-like lectin E)	protein interactions	83382	2	1	19454	50	PTPN6
5.134e-03	-5.27	CUZD1 (CUB and zona pellucida like domains 1)	protein interactions	50624	2	1	19454	50	PTPN6
5.134e-03	-5.27	HIF1A-AS2 (HIF1A antisense RNA 2)	protein interactions	100750247	2	1	19454	50	HIF1A
5.134e-03	-5.27	ALDOA (aldolase, fructose-bisphosphate A)	protein interactions	100009055	2	1	19454	50	WAS
5.153e-03	-5.27	IRS1 (insulin receptor substrate 1)	protein interactions	3667	136	3	19454	50	PIK3CB,PLCG2,PRKCD
5.153e-03	-5.27	NEFL (neurofilament light chain)	protein interactions	4747	136	3	19454	50	SKAP1,NEK6,GMIP
5.160e-03	-5.27	B cell differentiation	biological process	GO:0030183	130	3	18204	49	PLCG2,DOCK10,SYK
5.160e-03	-5.27	negative regulation of T cell activation	biological process	GO:0050868	130	3	18204	49	CD74,PTPN6,SLC4A2
5.187e-03	-5.26	positive regulation of nitric oxide metabolic process	biological process	GO:1904407	40	2	18204	49	PIK3CB,APOE
5.187e-03	-5.26	prostaglandin metabolic process	biological process	GO:0006693	40	2	18204	49	TBXAS1,CD74
5.188e-03	-5.26	CLEC7A (Dectin-1) signaling	REACTOME pathways	R-HSA-5607764	101	3	10285	36	PRKCD,PLCG2,SYK
5.215e-03	-5.26	negative regulation of multicellular organismal process	biological process	GO:0051241	1237	9	18204	49	SLC4A2,SEMA4A,PRKCD,PTPN6,ADCY7,CD74,PIK3CB,APOE,HIF1A
5.227e-03	-5.25	CSF1-CSF1R complex	cellular component	GO:1990682	2	1	19108	50	CSF1R
5.227e-03	-5.25	chylomicron remnant	cellular component	GO:0034360	2	1	19108	50	APOE
5.227e-03	-5.25	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	50	APOE
5.227e-03	-5.25	hippocampal mossy fiber expansion	cellular component	GO:1990026	2	1	19108	50	MICAL1
5.227e-03	-5.25	macrophage migration inhibitory factor receptor complex	cellular component	GO:0035692	2	1	19108	50	CD74
5.237e-03	-5.25	lymph_node	COSMIC cancer mutations	lymph_node	1703	11	16828	46	CSF1R,DOCK10,AKAP13,PIK3CB,DOCK2,CD74,SYK,ELMO1,HIF1A,PLCG2,DOCK1
5.253e-03	-5.25	RHOJ (ras homolog family member J)	protein interactions	57381	628	6	19454	50	SLC4A2,WAS,DOCK10,DOCK8,TBC1D8,GIT2
5.299e-03	-5.24	thromboxane-A synthase activity	molecular function	GO:0004796	2	1	18094	48	TBXAS1
5.299e-03	-5.24	interleukin-6 binding	molecular function	GO:0019981	2	1	18094	48	IL6R
5.299e-03	-5.24	macrophage migration inhibitory factor binding	molecular function	GO:0035718	2	1	18094	48	CD74
5.299e-03	-5.24	interleukin-6 receptor activity	molecular function	GO:0004915	2	1	18094	48	IL6R
5.299e-03	-5.24	macrophage colony-stimulating factor receptor activity	molecular function	GO:0005011	2	1	18094	48	CSF1R
5.299e-03	-5.24	G protein-coupled UDP receptor activity	molecular function	GO:0045029	2	1	18094	48	P2RY6
5.341e-03	-5.23	negative regulation of protein modification process	biological process	GO:0031400	421	5	18204	49	MICAL1,PRKCD,PTPN6,APOE,RGS14
5.376e-03	-5.23	inositol trisphosphate biosynthetic process	biological process	GO:0032959	2	1	18204	49	PLCG2
5.376e-03	-5.23	positive regulation of lipid transporter activity	biological process	GO:0110113	2	1	18204	49	PRKCD
5.376e-03	-5.23	serotonin secretion by platelet	biological process	GO:0002554	2	1	18204	49	SYK
5.376e-03	-5.23	sulfur oxidation	biological process	GO:0019417	2	1	18204	49	MICAL1
5.376e-03	-5.23	regulation of sphingomyelin catabolic process	biological process	GO:2000754	2	1	18204	49	PRKCD
5.376e-03	-5.23	positive regulation of inhibitory synapse assembly	biological process	GO:1905704	2	1	18204	49	SEMA4A
5.376e-03	-5.23	hepatic immune response	biological process	GO:0002384	2	1	18204	49	IL6R
5.376e-03	-5.23	regulation of interleukin-3 production	biological process	GO:0032672	2	1	18204	49	SYK
5.376e-03	-5.23	positive regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000448	2	1	18204	49	CD74
5.376e-03	-5.23	response to interleukin-11	biological process	GO:0071105	2	1	18204	49	SBNO2
5.376e-03	-5.23	positive regulation of sphingomyelin catabolic process	biological process	GO:2000755	2	1	18204	49	PRKCD
5.376e-03	-5.23	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	49	APOE
5.376e-03	-5.23	negative regulation of CD8-positive, alpha-beta T cell proliferation	biological process	GO:2000565	2	1	18204	49	SLC4A2
5.382e-03	-5.22	lung-carcinoma	COSMIC cancer mutations	lung-carcinoma	4255	20	16828	46	VAV3,SEMA4A,ARHGAP33,PLCG2,PREX1,PTPN6,WAS,IRF5,PIK3CB,GIT2,IL6R,AKAP13,NEK6,CSF1R,DOCK1,PIK3R5,HIF1A,PRKCD,SYK,RGS14
5.383e-03	-5.22	dendrite	cellular component	GO:0030425	620	6	19108	50	RIN3,DOCK10,APOE,ARHGAP33,RGS14,PREX1
5.392e-03	-5.22	HIF-1_CTAD	interpro domains	IPR014887	2	1	18521	50	HIF1A
5.392e-03	-5.22	iRhom1_2_N	interpro domains	IPR022241	2	1	18521	50	RHBDF2
5.392e-03	-5.22	GIT1/2_CC	interpro domains	IPR032352	2	1	18521	50	GIT2
5.392e-03	-5.22	GIT_SHD	interpro domains	IPR013724	2	1	18521	50	GIT2
5.392e-03	-5.22	SYK/ZAP-70_N_SH2	interpro domains	IPR035838	2	1	18521	50	SYK
5.392e-03	-5.22	PLC-gamma_N-SH2	interpro domains	IPR035024	2	1	18521	50	PLCG2
5.392e-03	-5.22	SKAP_fam	interpro domains	IPR037781	2	1	18521	50	SKAP1
5.392e-03	-5.22	WAS_C	interpro domains	IPR011026	2	1	18521	50	WAS
5.392e-03	-5.22	WASPfam_EVH1	interpro domains	IPR033927	2	1	18521	50	WAS
5.392e-03	-5.22	GSDME	interpro domains	IPR042377	2	1	18521	50	GSDME
5.392e-03	-5.22	GIT-like	interpro domains	IPR047161	2	1	18521	50	GIT2
5.392e-03	-5.22	GIT1_C	interpro domains	IPR022018	2	1	18521	50	GIT2
5.392e-03	-5.22	SNO	interpro domains	IPR026741	2	1	18521	50	SBNO2
5.392e-03	-5.22	Tyr_Pase_non-rcpt_typ-6/11	interpro domains	IPR012152	2	1	18521	50	PTPN6
5.392e-03	-5.22	Ie/If_SH3	interpro domains	IPR035507	2	1	18521	50	MYO1F
5.392e-03	-5.22	PLC-gamma	interpro domains	IPR016279	2	1	18521	50	PLCG2
5.392e-03	-5.22	PLC-gamma_C-SH2	interpro domains	IPR035023	2	1	18521	50	PLCG2
5.392e-03	-5.22	Kinase_SYK/ZAP-70_inter-SH2_sf	interpro domains	IPR023420	2	1	18521	50	SYK
5.392e-03	-5.22	DOCK1_5_SH3	interpro domains	IPR047025	2	1	18521	50	DOCK1
5.392e-03	-5.22	SBNO_Helicase_C_dom	interpro domains	IPR026937	2	1	18521	50	SBNO2
5.392e-03	-5.22	Tyr_kinase_non-rcpt_SYK/ZAP70	interpro domains	IPR012234	2	1	18521	50	SYK
5.392e-03	-5.22	PIK3R5/6	interpro domains	IPR019522	2	1	18521	50	PIK3R5
5.392e-03	-5.22	SNO_AAA	interpro domains	IPR039187	2	1	18521	50	SBNO2
5.443e-03	-5.21	prostanoid metabolic process	biological process	GO:0006692	41	2	18204	49	CD74,TBXAS1
5.467e-03	-5.21	dendritic tree	cellular component	GO:0097447	622	6	19108	50	DOCK10,RIN3,RGS14,APOE,ARHGAP33,PREX1
5.491e-03	-5.20	VEGFA-VEGFR2 Pathway	REACTOME pathways	R-HSA-4420097	330	5	10285	36	VAV3,ELMO1,DOCK1,PRKCD,PIK3CB
5.497e-03	-5.20	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	49	PLCG2,P2RY6,PTPN6
5.502e-03	-5.20	Regulation of Actin Cytoskeleton	WikiPathways	WP51	149	4	5310	26	PIK3CB,DOCK1,PIK3R5,WAS
5.547e-03	-5.19	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	50	NEK6,CSF1R,SYK
5.556e-03	-5.19	regulation of hemopoiesis	biological process	GO:1903706	425	5	18204	49	SLC4A2,PTPN6,SYK,CD74,HIF1A
5.612e-03	-5.18	HIF-1a_CTAD	pfam domains	PF08778	2	1	17795	50	HIF1A
5.612e-03	-5.18	PKC_C2	pfam domains	PF21494	2	1	17795	50	PRKCD
5.612e-03	-5.18	iRhom1-2_N	pfam domains	PF12595	2	1	17795	50	RHBDF2
5.612e-03	-5.18	GIT_SHD	pfam domains	PF08518	2	1	17795	50	GIT2
5.612e-03	-5.18	GIT_CC	pfam domains	PF16559	2	1	17795	50	GIT2
5.612e-03	-5.18	GIT1_C	pfam domains	PF12205	2	1	17795	50	GIT2
5.612e-03	-5.18	PI3K_1B_p101	pfam domains	PF10486	2	1	17795	50	PIK3R5
5.612e-03	-5.18	Helicase_C_4	pfam domains	PF13871	2	1	17795	50	SBNO2
5.612e-03	-5.18	AAA_34	pfam domains	PF13872	2	1	17795	50	SBNO2
5.612e-03	-5.18	growth factor binding	molecular function	GO:0019838	136	3	18094	48	RHBDF2,IL6R,CSF1R
5.669e-03	-5.17	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	37	16828	46	SKAP1,WDFY4,GMIP,DOCK10,ARHGAP33,DOCK8,IPCEF1,PREX1,IRF5,CD74,EHBP1L1,RHBDF2,AKAP13,NEK6,TBC1D8,RIN3,P2RY6,SYK,P2RY2,PARVG,VAV3,TBXAS1,MICAL1,PLCG2,PTPN6,ELMO1,PIK3CB,MYO1F,GIT2,DOCK2,ADCY7,CSF1R,PIK3R5,DOCK1,HIF1A,PRKCD,SLC4A2
5.669e-03	-5.17	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	37	16828	46	HIF1A,DOCK1,PIK3R5,SLC4A2,PRKCD,ADCY7,GIT2,DOCK2,PIK3CB,MYO1F,CSF1R,PLCG2,ELMO1,PTPN6,TBXAS1,VAV3,MICAL1,RIN3,PARVG,P2RY2,P2RY6,SYK,AKAP13,RHBDF2,EHBP1L1,CD74,IRF5,TBC1D8,NEK6,PREX1,IPCEF1,ARHGAP33,DOCK10,WDFY4,GMIP,SKAP1,DOCK8
5.696e-03	-5.17	NCAPD3 (non-SMC condensin II complex subunit D3)	protein interactions	23310	141	3	19454	50	P2RY6,SKAP1,CD74
5.706e-03	-5.17	positive regulation of interleukin-10 production	biological process	GO:0032733	42	2	18204	49	PLCG2,SYK
5.713e-03	-5.16	regulation of protein serine/threonine kinase activity	biological process	GO:0071900	267	4	18204	49	PRKCD,APOE,RGS14,PIK3R5
5.738e-03	-5.16	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	6	10285	36	VAV3,PREX1,ADCY7,PIK3CB,PRKCD,AKAP13
5.864e-03	-5.14	regulation of actin filament organization	biological process	GO:0110053	269	4	18204	49	PREX1,PRKCD,CARMIL3,WAS
5.875e-03	-5.14	Generation of second messenger molecules	REACTOME pathways	R-HSA-202433	33	2	10285	36	WAS,FYB1
5.973e-03	-5.12	SKAP2 (src kinase associated phosphoprotein 2)	protein interactions	8935	45	2	19454	50	FYB1,SKAP1
5.974e-03	-5.12	T-helper cell differentiation	biological process	GO:0042093	43	2	18204	49	SEMA4A,IL6R
5.974e-03	-5.12	CD4-positive, alpha-beta T cell differentiation involved in immune response	biological process	GO:0002294	43	2	18204	49	IL6R,SEMA4A
5.974e-03	-5.12	positive regulation of substrate adhesion-dependent cell spreading	biological process	GO:1900026	43	2	18204	49	PREX1,DOCK1
6.037e-03	-5.11	PTPN12 (protein tyrosine phosphatase non-receptor type 12)	protein interactions	5782	144	3	19454	50	WAS,EHBP1L1,PTPN6
6.037e-03	-5.11	COPG2 (COPI coat complex subunit gamma 2)	protein interactions	26958	144	3	19454	50	P2RY6,RHBDF2,CD74
6.071e-03	-5.10	Signaling by VEGF	REACTOME pathways	R-HSA-194138	338	5	10285	36	VAV3,DOCK1,ELMO1,PIK3CB,PRKCD
6.104e-03	-5.10	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	41	16828	46	DENND1B,DOCK8,SBNO2,DOCK10,ARHGAP33,SKAP1,GMIP,WDFY4,PREX1,IPCEF1,TBC1D8,NEK6,RHBDF2,EHBP1L1,AKAP13,IRF5,CD74,P2RY2,PARVG,SYK,GLIPR1,RIN3,MICAL1,TBXAS1,VAV3,WAS,ELMO1,PTPN6,PLCG2,CSF1R,ADCY7,PIK3CB,MYO1F,DOCK2,GIT2,SLC4A2,RGS14,PRKCD,HIF1A,DOCK1,PIK3R5
6.154e-03	-5.09	KDR (kinase insert domain receptor)	protein interactions	3791	145	3	19454	50	P2RY2,PTPN6,PLCG2
6.183e-03	-5.09	immunological synapse	cellular component	GO:0001772	45	2	19108	50	VAV3,SKAP1
6.229e-03	-5.08	DAG and IP3 signaling	REACTOME pathways	R-HSA-1489509	34	2	10285	36	ADCY7,PRKCD
6.247e-03	-5.08	alpha-beta T cell activation involved in immune response	biological process	GO:0002287	44	2	18204	49	IL6R,SEMA4A
6.247e-03	-5.08	alpha-beta T cell differentiation involved in immune response	biological process	GO:0002293	44	2	18204	49	IL6R,SEMA4A
6.324e-03	-5.06	protein tyrosine kinase activity	molecular function	GO:0004713	142	3	18094	48	SYK,CSF1R,PRKCD
6.344e-03	-5.06	non-membrane spanning protein tyrosine kinase activity	molecular function	GO:0004715	45	2	18094	48	SYK,PRKCD
6.404e-03	-5.05	regulation of apoptotic process	biological process	GO:0042981	1518	10	18204	49	HIF1A,PIK3CB,CSF1R,GSDME,CD74,PTPN6,PRKCD,MICAL1,IRF5,DOCK8
6.461e-03	-5.04	positive regulation of chemotaxis	biological process	GO:0050921	141	3	18204	49	IL6R,CSF1R,CD74
6.527e-03	-5.03	positive regulation of B cell proliferation	biological process	GO:0030890	45	2	18204	49	VAV3,CD74
6.527e-03	-5.03	plasma membrane invagination	biological process	GO:0099024	45	2	18204	49	ELMO1,DOCK1
6.527e-03	-5.03	negative regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050732	45	2	18204	49	PRKCD,PTPN6
6.527e-03	-5.03	negative regulation of blood coagulation	biological process	GO:0030195	45	2	18204	49	PRKCD,APOE
6.588e-03	-5.02	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	49	APOE,CD74,P2RY6
6.622e-03	-5.02	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	34	16828	46	MICAL1,VAV3,WAS,PTPN6,PLCG2,CSF1R,ADCY7,DOCK2,GIT2,PIK3CB,MYO1F,RGS14,PRKCD,HIF1A,PIK3R5,DOCK1,SBNO2,DOCK8,ARHGAP33,DOCK10,SEMA4A,WDFY4,SKAP1,PREX1,NEK6,AKAP13,IL6R,EHBP1L1,IRF5,PARVG,SYK,APOE,RIN3,GLIPR1
6.624e-03	-5.02	-	gene3d domains	6.10.250.220	2	1	14470	48	SKAP1
6.719e-03	-5.00	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	5	16828	46	CSF1R,SYK,PRKCD,NEK6,PIK3CB
6.767e-03	-5.00	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	4	5310	26	PRKCD,ADCY7,RGS14,PLCG2
6.772e-03	-4.99	CYTH2 (cytohesin 2)	protein interactions	9266	48	2	19454	50	DOCK1,IPCEF1
6.812e-03	-4.99	negative regulation of hemostasis	biological process	GO:1900047	46	2	18204	49	PRKCD,APOE
6.827e-03	-4.99	cytokine binding	molecular function	GO:0019955	146	3	18094	48	CD74,CSF1R,IL6R
6.903e-03	-4.98	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	16	18204	49	DENND1B,PLCG2,IRF5,SYK,WAS,SKAP1,SBNO2,P2RY6,PIK3R5,PRKCD,CD74,IL6R,CSF1R,PIK3CB,APOE,HIF1A
6.964e-03	-4.97	PLC-gamma1 signalling	REACTOME pathways	R-HSA-167021	36	2	10285	36	ADCY7,PRKCD
6.964e-03	-4.97	EGFR interacts with phospholipase C-gamma	REACTOME pathways	R-HSA-212718	36	2	10285	36	PRKCD,ADCY7
6.982e-03	-4.96	PTK2 (protein tyrosine kinase 2)	protein interactions	5747	296	4	19454	50	DOCK1,SYK,PTPN6,MICAL1
6.998e-03	-4.96	regulation of cell population proliferation	biological process	GO:0042127	1790	11	18204	49	IL6R,CSF1R,VAV3,P2RY6,APOE,TBC1D8,HIF1A,SLC4A2,PTPN6,CD74,GSDME
7.006e-03	-4.96	Class I PI3K signaling events	Pathway Interaction DB	pi3kcipathway	41	3	2226	22	PREX1,PIK3CB,PLCG2
7.009e-03	-4.96	regulation of defense response	biological process	GO:0031347	843	7	18204	49	PLCG2,RHBDF2,PRKCD,SYK,PTPN6,SBNO2,APOE
7.017e-03	-4.96	Estrogen signaling pathway	KEGG pathways	hsa04915	98	3	7161	29	PRKCD,ADCY7,PIK3CB
7.017e-03	-4.96	Estrogen signaling pathway	KEGG pathways	ko04915	98	3	7161	29	PRKCD,ADCY7,PIK3CB
7.049e-03	-4.95	CYTH1 (cytohesin 1)	protein interactions	9267	49	2	19454	50	PRKCD,IPCEF1
7.094e-03	-4.95	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	10	16828	46	ELMO1,PREX1,DOCK1,IPCEF1,DOCK10,AKAP13,VAV3,SKAP1,WDFY4,DOCK2
7.094e-03	-4.95	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	10	16828	46	DOCK1,IPCEF1,PREX1,ELMO1,WDFY4,DOCK2,SKAP1,VAV3,AKAP13,DOCK10
7.217e-03	-4.93	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	hsa04933	99	3	7161	29	PIK3CB,PRKCD,PLCG2
7.217e-03	-4.93	Choline metabolism in cancer	KEGG pathways	hsa05231	99	3	7161	29	WAS,PIK3CB,HIF1A
7.217e-03	-4.93	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	ko04933	99	3	7161	29	PRKCD,PIK3CB,PLCG2
7.217e-03	-4.93	Choline metabolism in cancer	KEGG pathways	ko05231	99	3	7161	29	PIK3CB,WAS,HIF1A
7.266e-03	-4.92	response to oxygen-containing compound	biological process	GO:1901700	1546	10	18204	49	TBXAS1,SBNO2,P2RY6,HIF1A,APOE,P2RY2,PLCG2,IRF5,PRKCD,ADCY7
7.330e-03	-4.92	TRIM15 (tripartite motif containing 15)	protein interactions	89870	50	2	19454	50	SYK,IRF5
7.346e-03	-4.91	regulation of canonical NF-kappaB signal transduction	biological process	GO:0043122	287	4	18204	49	NEK6,CD74,AKAP13,PLCG2
7.388e-03	-4.91	Signaling Pathways in Glioblastoma	WikiPathways	WP2261	83	3	5310	26	PRKCD,PLCG2,PIK3CB
7.399e-03	-4.91	T cell differentiation involved in immune response	biological process	GO:0002292	48	2	18204	49	SEMA4A,IL6R
7.399e-03	-4.91	regulation of inflammatory response to antigenic stimulus	biological process	GO:0002861	48	2	18204	49	SYK,RHBDF2
7.517e-03	-4.89	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	46	16828	46	VAV3,PTPN6,ELMO1,GIT2,MYO1F,ADCY7,RGS14,SLC4A2,WDFY4,DOCK8,DENND1B,IRF5,EHBP1L1,PARVG,TBXAS1,MICAL1,PLCG2,WAS,DOCK2,PIK3CB,CSF1R,PIK3R5,DOCK1,HIF1A,PRKCD,GMIP,SKAP1,ARHGAP33,DOCK10,SEMA4A,SBNO2,IPCEF1,PREX1,ARHGAP27,CD74,AKAP13,IL6R,RHBDF2,NEK6,TBC1D8,RIN3,GLIPR1,APOE,P2RY6,SYK,P2RY2
7.518e-03	-4.89	adenoma	COSMIC cancer mutations	adenoma	2873	15	16828	46	TBC1D8,PIK3CB,DOCK2,PRKCD,SYK,APOE,HIF1A,DOCK8,SKAP1,WDFY4,DOCK10,WAS,IPCEF1,PLCG2,PREX1
7.519e-03	-4.89	negative regulation of leukocyte cell-cell adhesion	biological process	GO:1903038	149	3	18204	49	SLC4A2,PTPN6,CD74
7.569e-03	-4.88	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	26	16828	46	PLCG2,ELMO1,ADCY7,DOCK2,MYO1F,PIK3CB,CSF1R,DOCK1,SLC4A2,PRKCD,RGS14,ARHGAP33,DOCK10,WDFY4,SKAP1,DOCK8,PREX1,IPCEF1,AKAP13,IRF5,TBC1D8,NEK6,PARVG,P2RY2,SYK,P2RY6
7.569e-03	-4.88	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	26	16828	46	DOCK1,P2RY2,SLC4A2,PARVG,PRKCD,SYK,P2RY6,RGS14,ADCY7,AKAP13,PIK3CB,IRF5,MYO1F,DOCK2,TBC1D8,NEK6,CSF1R,PREX1,PLCG2,IPCEF1,ELMO1,DOCK10,ARHGAP33,SKAP1,WDFY4,DOCK8
7.617e-03	-4.88	CD247 (CD247 molecule)	protein interactions	919	51	2	19454	50	PTPN6,DOCK2
7.617e-03	-4.88	IL4R (interleukin 4 receptor)	protein interactions	3566	51	2	19454	50	RHBDF2,PTPN6
7.631e-03	-4.88	human chr2q36.2	chromosome location	human chr2q36.2	4	1	26134	50	DOCK10
7.658e-03	-4.87	PPP6R1 (protein phosphatase 6 regulatory subunit 1)	protein interactions	22870	157	3	19454	50	IRF5,P2RY6,CD74
7.691e-03	-4.87	RAB6D (RAB6D, member RAS oncogene family)	protein interactions	150786	3	1	19454	50	RIN3
7.691e-03	-4.87	CX3CR1 (C-X3-C motif chemokine receptor 1)	protein interactions	1524	3	1	19454	50	HIF1A
7.691e-03	-4.87	SIGLEC11 (sialic acid binding Ig like lectin 11)	protein interactions	114132	3	1	19454	50	PTPN6
7.691e-03	-4.87	FAM220A (family with sequence similarity 220 member A)	protein interactions	84792	3	1	19454	50	NEK6
7.691e-03	-4.87	ARP2 (actin-related protein 2)	protein interactions	851532	3	1	19454	50	WAS
7.691e-03	-4.87	MPEG1 (macrophage expressed 1)	protein interactions	219972	3	1	19454	50	RIN3
7.691e-03	-4.87	Ahr (aryl-hydrocarbon receptor)	protein interactions	11622	3	1	19454	50	HIF1A
7.691e-03	-4.87	Cops5 (COP9 signalosome subunit 5)	protein interactions	26754	3	1	19454	50	HIF1A
7.691e-03	-4.87	SSX4B (SSX family member 4B)	protein interactions	548313	3	1	19454	50	HIF1A
7.691e-03	-4.87	Cbl (Casitas B-lineage lymphoma)	protein interactions	12402	3	1	19454	50	SYK
7.691e-03	-4.87	EPYC (epiphycan)	protein interactions	1833	3	1	19454	50	PLCG2
7.691e-03	-4.87	ORF34 (ORF34;ORF36)	protein interactions	4961504	3	1	19454	50	HIF1A
7.700e-03	-4.87	negative regulation of coagulation	biological process	GO:0050819	49	2	18204	49	PRKCD,APOE
7.700e-03	-4.87	platelet aggregation	biological process	GO:0070527	49	2	18204	49	PTPN6,PIK3CB
7.700e-03	-4.87	negative regulation of T cell differentiation	biological process	GO:0045581	49	2	18204	49	CD74,SLC4A2
7.700e-03	-4.87	visual learning	biological process	GO:0008542	49	2	18204	49	HIF1A,RGS14
7.830e-03	-4.85	ciliary neurotrophic factor receptor complex	cellular component	GO:0070110	3	1	19108	50	IL6R
7.830e-03	-4.85	interleukin-6 receptor complex	cellular component	GO:0005896	3	1	19108	50	IL6R
7.834e-03	-4.85	Focal adhesion	KEGG pathways	ko04510	198	4	7161	29	DOCK1,VAV3,PARVG,PIK3CB
7.834e-03	-4.85	Focal adhesion	KEGG pathways	hsa04510	198	4	7161	29	VAV3,DOCK1,PIK3CB,PARVG
7.836e-03	-4.85	T cell receptor signaling pathway	KEGG pathways	hsa04660	102	3	7161	29	PIK3CB,VAV3,PTPN6
7.836e-03	-4.85	T cell receptor signaling pathway	KEGG pathways	ko04660	102	3	7161	29	VAV3,PIK3CB,PTPN6
7.928e-03	-4.84	COG6 (component of oligomeric golgi complex 6)	protein interactions	57511	159	3	19454	50	NEK6,P2RY6,DOCK8
7.938e-03	-4.84	interleukin-11 receptor activity	molecular function	GO:0004921	3	1	18094	48	IL6R
7.938e-03	-4.84	interleukin-11 binding	molecular function	GO:0019970	3	1	18094	48	IL6R
7.938e-03	-4.84	A1 adenosine receptor binding	molecular function	GO:0031686	3	1	18094	48	P2RY2
7.938e-03	-4.84	12-hydroxyheptadecatrienoic acid synthase activity	molecular function	GO:0036134	3	1	18094	48	TBXAS1
7.938e-03	-4.84	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	molecular function	GO:0004699	3	1	18094	48	PRKCD
7.938e-03	-4.84	G protein-coupled ADP receptor activity	molecular function	GO:0001621	3	1	18094	48	P2RY6
7.941e-03	-4.84	regulation of lipid transport	biological process	GO:0032368	152	3	18204	49	PRKCD,SYK,APOE
7.941e-03	-4.84	regulation of tube diameter	biological process	GO:0035296	152	3	18204	49	TBXAS1,P2RY2,APOE
7.941e-03	-4.84	regulation of actin polymerization or depolymerization	biological process	GO:0008064	152	3	18204	49	PRKCD,PREX1,WAS
7.941e-03	-4.84	blood vessel diameter maintenance	biological process	GO:0097746	152	3	18204	49	TBXAS1,P2RY2,APOE
7.989e-03	-4.83	programmed cell death	biological process	GO:0012501	1087	8	18204	49	HIF1A,ELMO1,IL6R,PRKCD,NEK6,DOCK1,GSDME,PLCG2
8.007e-03	-4.83	modulation by host of viral process	biological process	GO:0044788	50	2	18204	49	APOE,CSF1R
8.011e-03	-4.83	GIT	smart domains	SM00555	2	1	9717	39	GIT2
8.054e-03	-4.82	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	49	APOE
8.054e-03	-4.82	negative regulation of synaptic plasticity	biological process	GO:0031914	3	1	18204	49	RGS14
8.054e-03	-4.82	beta selection	biological process	GO:0043366	3	1	18204	49	SYK
8.054e-03	-4.82	serotonin production involved in inflammatory response	biological process	GO:0002351	3	1	18204	49	SYK
8.054e-03	-4.82	negative regulation of CD8-positive, alpha-beta T cell differentiation	biological process	GO:0043377	3	1	18204	49	SLC4A2
8.054e-03	-4.82	positive regulation of excitatory synapse assembly	biological process	GO:1904891	3	1	18204	49	SEMA4A
8.054e-03	-4.82	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	biological process	GO:0086023	3	1	18204	49	AKAP13
8.054e-03	-4.82	follicular B cell differentiation	biological process	GO:0002316	3	1	18204	49	PLCG2
8.054e-03	-4.82	serotonin secretion involved in inflammatory response	biological process	GO:0002442	3	1	18204	49	SYK
8.054e-03	-4.82	termination of signal transduction	biological process	GO:0023021	3	1	18204	49	PRKCD
8.054e-03	-4.82	serotonin secretion	biological process	GO:0001820	3	1	18204	49	SYK
8.054e-03	-4.82	positive regulation of chemokine-mediated signaling pathway	biological process	GO:0070101	3	1	18204	49	HIF1A
8.054e-03	-4.82	membrane raft polarization	biological process	GO:0001766	3	1	18204	49	DOCK2
8.054e-03	-4.82	regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000446	3	1	18204	49	CD74
8.054e-03	-4.82	myeloid dendritic cell activation involved in immune response	biological process	GO:0002277	3	1	18204	49	DOCK2
8.054e-03	-4.82	positive regulation of phospholipid catabolic process	biological process	GO:0060697	3	1	18204	49	PRKCD
8.054e-03	-4.82	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	49	APOE
8.054e-03	-4.82	neural fold elevation formation	biological process	GO:0021502	3	1	18204	49	HIF1A
8.066e-03	-4.82	Signaling by the B Cell Receptor (BCR)	REACTOME pathways	R-HSA-983705	229	4	10285	36	PIK3CB,PTPN6,PLCG2,SYK
8.077e-03	-4.82	myeloid cell differentiation	biological process	GO:0030099	295	4	18204	49	CSF1R,SBNO2,SLC4A2,PTPN6
8.078e-03	-4.82	C2_Dock-D	interpro domains	IPR037809	3	1	18521	50	DOCK10
8.078e-03	-4.82	CARMIL_PH	interpro domains	IPR041245	3	1	18521	50	CARMIL3
8.078e-03	-4.82	ELMO_ARM	interpro domains	IPR024574	3	1	18521	50	ELMO1
8.078e-03	-4.82	DENND1A/B/C	interpro domains	IPR040032	3	1	18521	50	DENND1B
8.078e-03	-4.82	V5_allergen-like	interpro domains	IPR002413	3	1	18521	50	GLIPR1
8.078e-03	-4.82	RII-bd_1	interpro domains	IPR018459	3	1	18521	50	AKAP13
8.078e-03	-4.82	hSH3	interpro domains	IPR029294	3	1	18521	50	FYB1
8.078e-03	-4.82	SCP_GLIPR-1-like	interpro domains	IPR034121	3	1	18521	50	GLIPR1
8.078e-03	-4.82	Parvin	interpro domains	IPR028433	3	1	18521	50	PARVG
8.078e-03	-4.82	Anion_exchange	interpro domains	IPR001717	3	1	18521	50	SLC4A2
8.078e-03	-4.82	FYB1/2-like	interpro domains	IPR043443	3	1	18521	50	FYB1
8.078e-03	-4.82	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	50	HIF1A
8.078e-03	-4.82	RGS10/12/14-like	interpro domains	IPR046995	3	1	18521	50	RGS14
8.078e-03	-4.82	Anion_exchange_CS	interpro domains	IPR018241	3	1	18521	50	SLC4A2
8.078e-03	-4.82	C2_Dock-C	interpro domains	IPR037808	3	1	18521	50	DOCK8
8.078e-03	-4.82	CARMIL_C	interpro domains	IPR031943	3	1	18521	50	CARMIL3
8.078e-03	-4.82	PH_Vav	interpro domains	IPR037832	3	1	18521	50	VAV3
8.085e-03	-4.82	regulation of tube size	biological process	GO:0035150	153	3	18204	49	APOE,TBXAS1,P2RY2
8.085e-03	-4.82	myeloid leukocyte differentiation	biological process	GO:0002573	153	3	18204	49	CSF1R,SLC4A2,SBNO2
8.161e-03	-4.81	cell death	biological process	GO:0008219	1091	8	18204	49	PLCG2,DOCK1,NEK6,PRKCD,GSDME,IL6R,ELMO1,HIF1A
8.166e-03	-4.81	TCR signaling	REACTOME pathways	R-HSA-202403	119	3	10285	36	PIK3CB,FYB1,WAS
8.206e-03	-4.80	KLHDC10 (kelch domain containing 10)	protein interactions	23008	53	2	19454	50	PIK3CB,RIN3
8.206e-03	-4.80	GNA12 (G protein subunit alpha 12)	protein interactions	2768	53	2	19454	50	PRKCD,AKAP13
8.206e-03	-4.80	CLEC7A (C-type lectin domain containing 7A)	protein interactions	64581	53	2	19454	50	CD74,SYK
8.207e-03	-4.80	cytoplasm	cellular component	GO:0005737	12081	40	19108	50	MICAL1,DOCK10,HIF1A,DOCK2,CD74,RHBDF2,PIK3R5,WAS,PTPN6,CARMIL3,NEK6,EHBP1L1,IPCEF1,DOCK1,DENND1B,NRK,WDFY4,DOCK8,PRKCD,ARHGAP27,PIK3CB,SKAP1,GSDME,MYO1F,SYK,PLCG2,PARVG,APOE,AKAP13,ARHGAP33,VAV3,RGS14,RIN3,FYB1,PREX1,GMIP,TBXAS1,IRF5,ELMO1,GLIPR1
8.320e-03	-4.79	regulation of granulocyte chemotaxis	biological process	GO:0071622	51	2	18204	49	CD74,CSF1R
8.357e-03	-4.78	HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha)	protein interactions	3030	491	5	19454	50	SYK,P2RY6,APOE,CD74,RIN3
8.377e-03	-4.78	regulation of G protein-coupled receptor signaling pathway	biological process	GO:0008277	155	3	18204	49	RGS14,HIF1A,GIT2
8.377e-03	-4.78	regulation of actin filament length	biological process	GO:0030832	155	3	18204	49	WAS,PREX1,PRKCD
8.406e-03	-4.78	CARMIL_C	pfam domains	PF16000	3	1	17795	50	CARMIL3
8.406e-03	-4.78	Carm_PH	pfam domains	PF17888	3	1	17795	50	CARMIL3
8.406e-03	-4.78	HIF-1	pfam domains	PF11413	3	1	17795	50	HIF1A
8.406e-03	-4.78	hSH3	pfam domains	PF14603	3	1	17795	50	FYB1
8.406e-03	-4.78	PI3K_p85B	pfam domains	PF02192	3	1	17795	50	PIK3CB
8.406e-03	-4.78	RII_binding_1	pfam domains	PF10522	3	1	17795	50	AKAP13
8.406e-03	-4.78	ELMO_ARM	pfam domains	PF11841	3	1	17795	50	ELMO1
8.440e-03	-4.77	Fc Epsilon Receptor I Signaling in Mast Cells	SMPDB pathways	SMP0000358	34	2	1369	6	SYK,VAV3
8.542e-03	-4.76	Proteoglycans in cancer	KEGG pathways	hsa05205	203	4	7161	29	PIK3CB,HIF1A,PLCG2,PTPN6
8.542e-03	-4.76	Proteoglycans in cancer	KEGG pathways	ko05205	203	4	7161	29	PIK3CB,PLCG2,HIF1A,PTPN6
8.559e-03	-4.76	ATP5PO (ATP synthase peripheral stalk subunit OSCP)	protein interactions	539	314	4	19454	50	DOCK8,P2RY6,APOE,PREX1
8.607e-03	-4.76	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	6	18204	49	WAS,ARHGAP33,PRKCD,PREX1,TBC1D8,APOE
8.638e-03	-4.75	membrane invagination	biological process	GO:0010324	52	2	18204	49	ELMO1,DOCK1
8.675e-03	-4.75	phosphatidylinositol metabolic process	biological process	GO:0046488	157	3	18204	49	PLCG2,PIK3CB,PIK3R5
8.688e-03	-4.75	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	7	16828	46	PRKCD,SYK,RIN3,CSF1R,NEK6,RHBDF2,ADCY7
8.814e-03	-4.73	DOCK1 (dedicator of cytokinesis 1)	protein interactions	1793	55	2	19454	50	ELMO1,IPCEF1
8.962e-03	-4.71	positive regulation of calcium-mediated signaling	biological process	GO:0050850	53	2	18204	49	PLCG2,SYK
9.058e-03	-4.70	Signaling by Interleukins	REACTOME pathways	R-HSA-449147	525	6	10285	36	HIF1A,PIK3CB,IL6R,PTPN6,CSF1R,SYK
9.125e-03	-4.70	EML3 (EMAP like 3)	protein interactions	256364	56	2	19454	50	SKAP1,NEK6
9.125e-03	-4.70	PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)	protein interactions	5294	56	2	19454	50	SYK,PIK3R5
9.201e-03	-4.69	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	6	18094	48	SYK,NRK,CSF1R,PIK3CB,PRKCD,NEK6
9.212e-03	-4.69	KLK10 (kallikrein related peptidase 10)	protein interactions	5655	168	3	19454	50	MYO1F,APOE,PTPN6
9.212e-03	-4.69	GAB1 (GRB2 associated binding protein 1)	protein interactions	2549	168	3	19454	50	PLCG2,SYK,VAV3
9.290e-03	-4.68	negative regulation of supramolecular fiber organization	biological process	GO:1902904	161	3	18204	49	APOE,PRKCD,WAS
9.290e-03	-4.68	positive regulation of receptor-mediated endocytosis	biological process	GO:0048260	54	2	18204	49	SYK,PLCG2
9.290e-03	-4.68	regulation of alcohol biosynthetic process	biological process	GO:1902930	54	2	18204	49	APOE,P2RY6
9.300e-03	-4.68	phospholipid binding	molecular function	GO:0005543	489	5	18094	48	GSDME,PREX1,DENND1B,ARHGAP33,APOE
9.303e-03	-4.68	Prot_kinase_dom	interpro domains	IPR000719	480	5	18521	50	NRK,CSF1R,NEK6,SYK,PRKCD
9.391e-03	-4.67	upper_leg	COSMIC cancer mutations	upper_leg	880	7	16828	46	DOCK2,VAV3,SEMA4A,CSF1R,NEK6,DOCK8,ELMO1
9.442e-03	-4.66	PTPRC (protein tyrosine phosphatase receptor type C)	protein interactions	5788	57	2	19454	50	PTPN6,SKAP1
9.442e-03	-4.66	PRKCQ (protein kinase C theta)	protein interactions	5588	57	2	19454	50	PRKCD,FYB1
9.442e-03	-4.66	ITK (IL2 inducible T cell kinase)	protein interactions	3702	57	2	19454	50	PLCG2,WAS
9.442e-03	-4.66	DOCK9 (dedicator of cytokinesis 9)	protein interactions	23348	57	2	19454	50	DOCK1,DOCK10
9.444e-03	-4.66	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	14	16828	46	PLCG2,ELMO1,PTPN6,DOCK10,VAV3,WDFY4,DOCK8,APOE,RIN3,DOCK1,SLC4A2,PARVG,EHBP1L1,AKAP13
9.444e-03	-4.66	embryonal	COSMIC cancer mutations	embryonal	2659	14	16828	46	DOCK8,VAV3,WDFY4,DOCK10,ELMO1,PTPN6,PLCG2,EHBP1L1,AKAP13,SLC4A2,PARVG,DOCK1,RIN3,APOE
9.503e-03	-4.66	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	19	16828	46	SBNO2,MICAL1,DOCK8,WDFY4,VAV3,DOCK10,ELMO1,PTPN6,PLCG2,CSF1R,TBC1D8,AKAP13,EHBP1L1,PARVG,SLC4A2,RIN3,DOCK1,GLIPR1,APOE
9.521e-03	-4.65	RHOU (ras homolog family member U)	protein interactions	58480	507	5	19454	50	SYK,GIT2,TBC1D8,SLC4A2,EHBP1L1
9.544e-03	-4.65	defense response to symbiont	biological process	GO:0140546	894	7	18204	49	CD74,SYK,PTPN6,PLCG2,IRF5,CSF1R,WAS
9.548e-03	-4.65	response to bacterium	biological process	GO:0009617	681	6	18204	49	IL6R,SBNO2,SYK,PRKCD,PLCG2,IRF5
9.575e-03	-4.65	negative regulation of cell adhesion	biological process	GO:0007162	310	4	18204	49	SLC4A2,CD74,PTPN6,PRKCD
9.579e-03	-4.65	human chr11q13.4	chromosome location	human chr11q13.4	77	2	26134	50	P2RY2,P2RY6
9.606e-03	-4.65	receptor-mediated endocytosis	biological process	GO:0006898	163	3	18204	49	APOE,SYK,ARHGAP27
9.625e-03	-4.64	neural crest cell migration	biological process	GO:0001755	55	2	18204	49	SEMA4A,HIF1A
9.625e-03	-4.64	CD4-positive, alpha-beta T cell differentiation	biological process	GO:0043367	55	2	18204	49	IL6R,SEMA4A
9.665e-03	-4.64	PACSIN2 (protein kinase C and casein kinase substrate in neurons 2)	protein interactions	11252	171	3	19454	50	IRF5,RIN3,WAS
9.679e-03	-4.64	regulation of cell projection organization	biological process	GO:0031344	683	6	18204	49	PREX1,PRKCD,ARHGAP33,TBC1D8,APOE,WAS
9.761e-03	-4.63	Regulation of actin cytoskeleton	KEGG pathways	ko04810	211	4	7161	29	DOCK1,WAS,VAV3,PIK3CB
9.761e-03	-4.63	Regulation of actin cytoskeleton	KEGG pathways	hsa04810	211	4	7161	29	PIK3CB,DOCK1,WAS,VAV3
9.767e-03	-4.63	negative regulation of lymphocyte activation	biological process	GO:0051250	164	3	18204	49	SLC4A2,PTPN6,CD74
9.767e-03	-4.63	positive regulation of leukocyte proliferation	biological process	GO:0070665	164	3	18204	49	CD74,VAV3,CSF1R
9.809e-03	-4.62	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	20	16828	46	HIF1A,DOCK1,PIK3R5,RGS14,SYK,PRKCD,IL6R,AKAP13,PIK3CB,IRF5,GIT2,NEK6,CSF1R,PREX1,PLCG2,WAS,PTPN6,SEMA4A,ARHGAP33,VAV3
9.919e-03	-4.61	-	gene3d domains	6.10.140.1000	3	1	14470	48	DENND1B
9.919e-03	-4.61	-	gene3d domains	3.10.20.770	3	1	14470	48	PIK3CB
9.919e-03	-4.61	-	gene3d domains	6.10.250.810	3	1	14470	48	ELMO1
9.964e-03	-4.61	B cell activation involved in immune response	biological process	GO:0002312	56	2	18204	49	DOCK10,PLCG2
9.975e-03	-4.61	THOC2 (THO complex subunit 2)	protein interactions	57187	173	3	19454	50	SLC4A2,TBC1D8,P2RY6
1.008e-02	-4.60	cellular homeostasis	biological process	GO:0019725	689	6	18204	49	PIK3CB,APOE,HIF1A,TBXAS1,P2RY2,SLC4A2
1.009e-02	-4.60	C1_1	pfam domains	PF00130	54	2	17795	50	PRKCD,VAV3
1.009e-02	-4.60	lymphocyte mediated immunity	biological process	GO:0002449	166	3	18204	49	CD74,PTPN6,PRKCD
1.012e-02	-4.59	Cholinergic synapse	KEGG pathways	hsa04725	112	3	7161	29	PIK3CB,PIK3R5,ADCY7
1.013e-02	-4.59	GYPA (glycophorin A (MNS blood group))	protein interactions	2993	174	3	19454	50	GSDME,DOCK1,NEK6
1.013e-02	-4.59	SURF4 (surfeit 4)	protein interactions	6836	174	3	19454	50	DOCK1,P2RY6,P2RY2
1.024e-02	-4.58	OR52I1 (olfactory receptor family 52 subfamily I member 1)	protein interactions	390037	4	1	19454	50	SLC4A2
1.024e-02	-4.58	CYP46A1 (cytochrome P450 family 46 subfamily A member 1)	protein interactions	10858	4	1	19454	50	RIN3
1.024e-02	-4.58	H1-10-AS1 (H1-10 antisense RNA 1)	protein interactions	339942	4	1	19454	50	PTPN6
1.024e-02	-4.58	Mapk1 (mitogen activated protein kinase 1)	protein interactions	116590	4	1	19454	50	HIF1A
1.024e-02	-4.58	PLEKHD1 (pleckstrin homology and coiled-coil domain containing D1)	protein interactions	400224	4	1	19454	50	SYK
1.024e-02	-4.58	CD34 (CD34 molecule)	protein interactions	947	4	1	19454	50	PRKCD
1.024e-02	-4.58	ANKRD42 (ankyrin repeat domain 42)	protein interactions	338699	4	1	19454	50	RIN3
1.024e-02	-4.58	Ocln (occludin)	protein interactions	18260	4	1	19454	50	PRKCD
1.030e-02	-4.58	ANIONEXCHNGR	prints domains	PR00165	3	1	5227	18	SLC4A2
1.030e-02	-4.58	V5ALLERGEN	prints domains	PR00838	3	1	5227	18	GLIPR1
1.031e-02	-4.58	dendritic spine	cellular component	GO:0043197	172	3	19108	50	ARHGAP33,RGS14,DOCK10
1.031e-02	-4.57	visual behavior	biological process	GO:0007632	57	2	18204	49	HIF1A,RGS14
1.031e-02	-4.57	mesenchymal cell migration	biological process	GO:0090497	57	2	18204	49	SEMA4A,HIF1A
1.042e-02	-4.56	CA2 (carbonic anhydrase 2)	protein interactions	760	60	2	19454	50	SLC4A2,VAV3
1.043e-02	-4.56	phosphatidylinositol 3-kinase complex, class IB	cellular component	GO:0005944	4	1	19108	50	PIK3R5
1.043e-02	-4.56	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	50	APOE
1.047e-02	-4.56	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME pathways	R-HSA-1234162	3	1	10285	36	HIF1A
1.056e-02	-4.55	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	15	16828	46	PIK3R5,RIN3,HIF1A,SYK,P2RY6,PRKCD,P2RY2,PIK3CB,CSF1R,PLCG2,PTPN6,ELMO1,WAS,VAV3,TBXAS1
1.056e-02	-4.55	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	15	16828	46	VAV3,TBXAS1,PLCG2,ELMO1,PTPN6,WAS,PIK3CB,CSF1R,RIN3,PIK3R5,HIF1A,SYK,P2RY6,PRKCD,P2RY2
1.057e-02	-4.55	MCM3 (minichromosome maintenance complex component 3)	protein interactions	4172	334	4	19454	50	HIF1A,P2RY6,DOCK8,RIN3
1.057e-02	-4.55	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	48	APOE
1.057e-02	-4.55	ciliary neurotrophic factor receptor activity	molecular function	GO:0004897	4	1	18094	48	IL6R
1.062e-02	-4.54	Leukocyte transendothelial migration	KEGG pathways	ko04670	114	3	7161	29	PIK3CB,VAV3,PLCG2
1.062e-02	-4.54	Leukocyte transendothelial migration	KEGG pathways	hsa04670	114	3	7161	29	PIK3CB,VAV3,PLCG2
1.063e-02	-4.54	neuron spine	cellular component	GO:0044309	174	3	19108	50	ARHGAP33,DOCK10,RGS14
1.066e-02	-4.54	negative regulation of lymphocyte differentiation	biological process	GO:0045620	58	2	18204	49	CD74,SLC4A2
1.066e-02	-4.54	mammary gland epithelium development	biological process	GO:0061180	58	2	18204	49	CSF1R,HIF1A
1.070e-02	-4.54	negative regulation of apoptotic process	biological process	GO:0043066	914	7	18204	49	CSF1R,MICAL1,DOCK8,HIF1A,CD74,PIK3CB,PRKCD
1.071e-02	-4.54	G Protein Signaling Pathways	WikiPathways	WP35	95	3	5310	26	PRKCD,AKAP13,ADCY7
1.072e-02	-4.54	positive regulation of establishment of T cell polarity	biological process	GO:1903905	4	1	18204	49	DOCK8
1.072e-02	-4.54	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	49	APOE
1.072e-02	-4.54	negative regulation of mature B cell apoptotic process	biological process	GO:0002906	4	1	18204	49	CD74
1.072e-02	-4.54	cellular response to molecule of fungal origin	biological process	GO:0071226	4	1	18204	49	SYK
1.072e-02	-4.54	positive regulation of neutrophil apoptotic process	biological process	GO:0033031	4	1	18204	49	PIK3CB
1.072e-02	-4.54	B-1 B cell homeostasis	biological process	GO:0001922	4	1	18204	49	HIF1A
1.072e-02	-4.54	regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032960	4	1	18204	49	P2RY6
1.072e-02	-4.54	response to caloric restriction	biological process	GO:0061771	4	1	18204	49	APOE
1.072e-02	-4.54	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	49	APOE
1.072e-02	-4.54	negative regulation of mast cell activation involved in immune response	biological process	GO:0033007	4	1	18204	49	PTPN6
1.072e-02	-4.54	regulation of inhibitory synapse assembly	biological process	GO:1905702	4	1	18204	49	SEMA4A
1.072e-02	-4.54	epithelial cell differentiation involved in mammary gland alveolus development	biological process	GO:0061030	4	1	18204	49	HIF1A
1.072e-02	-4.54	regulation of mature B cell apoptotic process	biological process	GO:0002905	4	1	18204	49	CD74
1.072e-02	-4.54	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031587	4	1	18204	49	P2RY6
1.072e-02	-4.54	positive regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032962	4	1	18204	49	P2RY6
1.072e-02	-4.54	macrophage colony-stimulating factor signaling pathway	biological process	GO:0038145	4	1	18204	49	CSF1R
1.072e-02	-4.54	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	49	APOE
1.072e-02	-4.54	positive regulation of endodeoxyribonuclease activity	biological process	GO:0032079	4	1	18204	49	PRKCD
1.072e-02	-4.54	positive regulation of mast cell cytokine production	biological process	GO:0032765	4	1	18204	49	SYK
1.076e-02	-4.53	ApoA_E	interpro domains	IPR000074	4	1	18521	50	APOE
1.076e-02	-4.53	PI3K_ABD	interpro domains	IPR003113	4	1	18521	50	PIK3CB
1.076e-02	-4.53	NT-C2	interpro domains	IPR019448	4	1	18521	50	EHBP1L1
1.076e-02	-4.53	Prot_kin_PKC_delta	interpro domains	IPR014376	4	1	18521	50	PRKCD
1.076e-02	-4.53	FBXL12 (F-box and leucine rich repeat protein 12)	protein interactions	54850	61	2	19454	50	APOE,DOCK8
1.076e-02	-4.53	negative regulation of protein kinase activity	biological process	GO:0006469	170	3	18204	49	RGS14,APOE,PRKCD
1.077e-02	-4.53	IPO8 (importin 8)	protein interactions	10526	178	3	19454	50	P2RY6,P2RY2,RIN3
1.079e-02	-4.53	skin-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma	493	5	16828	46	SYK,CSF1R,WAS,HIF1A,ARHGAP33
1.099e-02	-4.51	PI3K-Akt signaling pathway	KEGG pathways	hsa04151	341	5	7161	29	SYK,CSF1R,PIK3CB,IL6R,PIK3R5
1.099e-02	-4.51	PI3K-Akt signaling pathway	KEGG pathways	ko04151	341	5	7161	29	IL6R,PIK3R5,PIK3CB,SYK,CSF1R
1.104e-02	-4.51	ANION_EXCHANGER_1	prosite domains	PS00219	3	1	12186	45	SLC4A2
1.104e-02	-4.51	ANION_EXCHANGER_2	prosite domains	PS00220	3	1	12186	45	SLC4A2
1.106e-02	-4.50	Cell-Cell communication	REACTOME pathways	R-HSA-1500931	133	3	10285	36	FYB1,PTPN6,PIK3CB
1.108e-02	-4.50	protein phosphorylation	biological process	GO:0006468	503	5	18204	49	NEK6,PTPN6,PRKCD,SYK,CSF1R
1.111e-02	-4.50	negative regulation of secretion	biological process	GO:0051048	172	3	18204	49	APOE,RHBDF2,CD74
1.112e-02	-4.50	cytoplasmic vesicle	cellular component	GO:0031410	2521	13	19108	50	EHBP1L1,RIN3,DOCK2,PRKCD,MICAL1,APOE,WDFY4,GLIPR1,PTPN6,WAS,DENND1B,CD74,SYK
1.114e-02	-4.50	Thyroid hormone signaling pathway	KEGG pathways	hsa04919	116	3	7161	29	PIK3CB,HIF1A,PLCG2
1.119e-02	-4.49	NT-C2	pfam domains	PF10358	4	1	17795	50	EHBP1L1
1.119e-02	-4.49	Apolipoprotein	pfam domains	PF01442	4	1	17795	50	APOE
1.127e-02	-4.49	PRKD1 (protein kinase D1)	protein interactions	5587	181	3	19454	50	PLCG2,SYK,AKAP13
1.128e-02	-4.48	regulation of smooth muscle cell proliferation	biological process	GO:0048660	173	3	18204	49	P2RY6,APOE,IL6R
1.137e-02	-4.48	positive regulation of cytokine-mediated signaling pathway	biological process	GO:0001961	60	2	18204	49	CD74,HIF1A
1.144e-02	-4.47	PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)	protein interactions	55824	63	2	19454	50	PTPN6,SYK
1.145e-02	-4.47	TOP3B (DNA topoisomerase III beta)	protein interactions	8940	1465	9	19454	50	SBNO2,RIN3,PREX1,ARHGAP33,AKAP13,IRF5,ADCY7,RHBDF2,EHBP1L1
1.148e-02	-4.47	Signaling by GPCR	REACTOME pathways	R-HSA-372790	1299	10	10285	36	PIK3CB,ADCY7,PRKCD,P2RY2,AKAP13,RGS14,P2RY6,PREX1,PIK3R5,VAV3
1.148e-02	-4.47	regulation of lipid metabolic process	biological process	GO:0019216	327	4	18204	49	PLCG2,PRKCD,CD74,APOE
1.148e-02	-4.47	specific granule lumen	cellular component	GO:0035580	62	2	19108	50	PTPN6,DOCK2
1.153e-02	-4.46	circulatory system process	biological process	GO:0003013	508	5	18204	49	APOE,TBC1D8,TBXAS1,P2RY2,AKAP13
1.160e-02	-4.46	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	5	16828	46	TBC1D8,CSF1R,NEK6,SYK,PRKCD
1.161e-02	-4.46	SORBS3 (sorbin and SH3 domain containing 3)	protein interactions	10174	183	3	19454	50	NEK6,RIN3,MICAL1
1.166e-02	-4.45	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	19	16828	46	PTPN6,ELMO1,PLCG2,DOCK8,MICAL1,SBNO2,DOCK10,VAV3,WDFY4,SLC4A2,PARVG,APOE,RIN3,GLIPR1,DOCK1,TBC1D8,CSF1R,EHBP1L1,AKAP13
1.167e-02	-4.45	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	2	10285	36	ADCY7,PRKCD
1.169e-02	-4.45	cell differentiation	biological process	GO:0030154	3645	17	18204	49	APOE,HIF1A,IL6R,CSF1R,DOCK2,SEMA4A,CD74,PREX1,AKAP13,SBNO2,DOCK10,PTPN6,DOCK1,SYK,GSDME,SLC4A2,PLCG2
1.172e-02	-4.45	regulation of leukocyte differentiation	biological process	GO:1902105	329	4	18204	49	SLC4A2,PTPN6,SYK,CD74
1.174e-02	-4.44	bone mineralization	biological process	GO:0030282	61	2	18204	49	HIF1A,SBNO2
1.174e-02	-4.44	Cell surface interactions at the vascular wall	REACTOME pathways	R-HSA-202733	136	3	10285	36	PIK3CB,PTPN6,CD74
1.175e-02	-4.44	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	22	16828	46	PREX1,DOCK10,SEMA4A,ARHGAP33,WDFY4,SYK,IL6R,AKAP13,IRF5,NEK6,PLCG2,WAS,PTPN6,VAV3,HIF1A,PIK3R5,DOCK1,RGS14,PRKCD,PIK3CB,GIT2,CSF1R
1.175e-02	-4.44	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	22	16828	46	WDFY4,ARHGAP33,DOCK10,SEMA4A,PREX1,IRF5,AKAP13,IL6R,NEK6,SYK,VAV3,PLCG2,PTPN6,WAS,GIT2,PIK3CB,CSF1R,PIK3R5,DOCK1,HIF1A,RGS14,PRKCD
1.178e-02	-4.44	SDHB (succinate dehydrogenase complex iron sulfur subunit B)	protein interactions	6390	184	3	19454	50	RIN3,P2RY6,PIK3R5
1.179e-02	-4.44	cellular developmental process	biological process	GO:0048869	3648	17	18204	49	SBNO2,DOCK10,PTPN6,DOCK1,SYK,GSDME,SLC4A2,PLCG2,HIF1A,APOE,IL6R,CSF1R,DOCK2,SEMA4A,CD74,PREX1,AKAP13
1.179e-02	-4.44	DGKE (diacylglycerol kinase epsilon)	protein interactions	8526	64	2	19454	50	P2RY6,CD74
1.179e-02	-4.44	LRCH2 (leucine rich repeats and calponin homology domain containing 2)	protein interactions	57631	64	2	19454	50	DOCK8,DOCK2
1.190e-02	-4.43	circulatory system development	biological process	GO:0072359	933	7	18204	49	APOE,HIF1A,PIK3CB,VAV3,SEMA4A,SYK,AKAP13
1.194e-02	-4.43	Neurotrophin signaling pathway	KEGG pathways	ko04722	119	3	7161	29	PLCG2,PIK3CB,PRKCD
1.194e-02	-4.43	Neurotrophin signaling pathway	KEGG pathways	hsa04722	119	3	7161	29	PLCG2,PRKCD,PIK3CB
1.195e-02	-4.43	APBB1 (amyloid beta precursor protein binding family B member 1)	protein interactions	322	185	3	19454	50	WAS,RHBDF2,ELMO1
1.196e-02	-4.43	regulation of small molecule metabolic process	biological process	GO:0062012	331	4	18204	49	HIF1A,APOE,CD74,P2RY6
1.199e-02	-4.42	PI3K_p85B	smart domains	SM00143	3	1	9717	39	PIK3CB
1.211e-02	-4.41	regulation of substrate adhesion-dependent cell spreading	biological process	GO:1900024	62	2	18204	49	PREX1,DOCK1
1.215e-02	-4.41	ESRRA (estrogen related receptor alpha)	protein interactions	2101	65	2	19454	50	HIF1A,PRKCD
1.215e-02	-4.41	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	2	10285	36	PRKCD,ADCY7
1.215e-02	-4.41	G beta:gamma signalling through PI3Kgamma	REACTOME pathways	R-HSA-392451	48	2	10285	36	PIK3CB,PIK3R5
1.215e-02	-4.41	G alpha (z) signalling events	REACTOME pathways	R-HSA-418597	48	2	10285	36	PRKCD,ADCY7
1.221e-02	-4.41	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	5	12186	45	SYK,CSF1R,NRK,NEK6,PRKCD
1.237e-02	-4.39	regulation of response to wounding	biological process	GO:1903034	179	3	18204	49	APOE,PTPN6,PRKCD
1.246e-02	-4.39	peptidyl-amino acid modification	biological process	GO:0018193	518	5	18204	49	CSF1R,SYK,PRKCD,PTPN6,NEK6
1.249e-02	-4.38	regulation of nitric oxide biosynthetic process	biological process	GO:0045428	63	2	18204	49	APOE,PIK3CB
1.249e-02	-4.38	response to fungus	biological process	GO:0009620	63	2	18204	49	PLCG2,SYK
1.249e-02	-4.38	positive regulation of interleukin-8 production	biological process	GO:0032757	63	2	18204	49	CD74,SYK
1.266e-02	-4.37	APPBP2 (amyloid beta precursor protein binding protein 2)	protein interactions	10513	189	3	19454	50	SKAP1,DOCK8,WAS
1.274e-02	-4.36	DDX54 (DEAD-box helicase 54)	protein interactions	79039	353	4	19454	50	PTPN6,SEMA4A,SYK,MYO1F
1.274e-02	-4.36	negative regulation of kinase activity	biological process	GO:0033673	181	3	18204	49	PRKCD,APOE,RGS14
1.274e-02	-4.36	response to reactive oxygen species	biological process	GO:0000302	181	3	18204	49	APOE,HIF1A,PRKCD
1.277e-02	-4.36	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	10	18204	49	PLCG2,ADCY7,PTPN6,NEK6,SYK,PRKCD,CSF1R,PIK3R5,PIK3CB,NRK
1.279e-02	-4.36	VHLL (VHL like)	protein interactions	391104	5	1	19454	50	HIF1A
1.279e-02	-4.36	LINC01139 (long intergenic non-protein coding RNA 1139)	protein interactions	339535	5	1	19454	50	HIF1A
1.279e-02	-4.36	Vhl (von Hippel-Lindau tumor suppressor)	protein interactions	24874	5	1	19454	50	HIF1A
1.279e-02	-4.36	NBR2 (neighbor of BRCA1 lncRNA 2)	protein interactions	10230	5	1	19454	50	GMIP
1.279e-02	-4.36	ANGPTL2 (angiopoietin like 2)	protein interactions	23452	5	1	19454	50	RIN3
1.279e-02	-4.36	SNHG11 (small nucleolar RNA host gene 11)	protein interactions	128439	5	1	19454	50	HIF1A
1.279e-02	-4.36	PSPN (persephin)	protein interactions	5623	5	1	19454	50	MICAL1
1.279e-02	-4.36	CKLF (chemokine like factor)	protein interactions	51192	5	1	19454	50	GLIPR1
1.279e-02	-4.36	GIMAP6 (GTPase, IMAP family member 6)	protein interactions	474344	5	1	19454	50	MICAL1
1.279e-02	-4.36	NBPF6 (NBPF member 6)	protein interactions	653149	5	1	19454	50	PARVG
1.279e-02	-4.36	regulation of protein metabolic process	biological process	GO:0051246	2218	12	18204	49	SYK,PTPN6,PLCG2,MICAL1,PIK3R5,CD74,PRKCD,HIF1A,APOE,RGS14,CSF1R,IL6R
1.281e-02	-4.36	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	36	16828	46	ELMO1,PTPN6,PLCG2,MICAL1,TBXAS1,VAV3,SLC4A2,RGS14,PRKCD,DOCK1,PIK3R5,CSF1R,ADCY7,DOCK2,GIT2,MYO1F,PREX1,ARHGAP27,IPCEF1,SBNO2,DOCK8,DENND1B,ARHGAP33,DOCK10,GMIP,SKAP1,PARVG,P2RY2,SYK,P2RY6,APOE,RIN3,TBC1D8,AKAP13,RHBDF2,IRF5
1.281e-02	-4.36	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	36	16828	46	DOCK10,ARHGAP33,SKAP1,GMIP,DENND1B,DOCK8,SBNO2,ARHGAP27,PREX1,IPCEF1,RHBDF2,AKAP13,IRF5,TBC1D8,APOE,RIN3,P2RY2,PARVG,SYK,P2RY6,TBXAS1,VAV3,MICAL1,PLCG2,PTPN6,ELMO1,ADCY7,MYO1F,GIT2,DOCK2,CSF1R,PIK3R5,DOCK1,SLC4A2,PRKCD,RGS14
1.287e-02	-4.35	regulation of B cell proliferation	biological process	GO:0030888	64	2	18204	49	CD74,VAV3
1.296e-02	-4.35	kinase activity	molecular function	GO:0016301	739	6	18094	48	NRK,CSF1R,SYK,PRKCD,PIK3CB,NEK6
1.302e-02	-4.34	B cell receptor complex	cellular component	GO:0019815	5	1	19108	50	SYK
1.302e-02	-4.34	alpha-beta T cell receptor complex	cellular component	GO:0042105	5	1	19108	50	PTPN6
1.307e-02	-4.34	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	12	19108	50	PREX1,DOCK8,CARMIL3,RIN3,PLCG2,APOE,ARHGAP33,RGS14,MYO1F,MICAL1,HIF1A,DOCK10
1.312e-02	-4.33	regulation of lipid localization	biological process	GO:1905952	183	3	18204	49	SYK,PRKCD,APOE
1.313e-02	-4.33	Synthesis of PIPs at the plasma membrane	REACTOME pathways	R-HSA-1660499	50	2	10285	36	PIK3CB,PIK3R5
1.320e-02	-4.33	NADPH oxidase H202-forming activity	molecular function	GO:0106294	5	1	18094	48	MICAL1
1.320e-02	-4.33	UBE3C (ubiquitin protein ligase E3C)	protein interactions	9690	192	3	19454	50	CD74,P2RY6,HIF1A
1.324e-02	-4.32	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	COSMIC cancer mutations	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	181	3	16828	46	ELMO1,WDFY4,VAV3
1.325e-02	-4.32	regulation of nitric oxide metabolic process	biological process	GO:0080164	65	2	18204	49	APOE,PIK3CB
1.325e-02	-4.32	regulation of interleukin-10 production	biological process	GO:0032653	65	2	18204	49	SYK,PLCG2
1.325e-02	-4.32	T cell differentiation in thymus	biological process	GO:0033077	65	2	18204	49	DOCK2,CD74
1.331e-02	-4.32	multivesicular body	cellular component	GO:0005771	67	2	19108	50	CD74,APOE
1.333e-02	-4.32	Integrin-mediated Cell Adhesion	WikiPathways	WP185	103	3	5310	26	GIT2,VAV3,DOCK1
1.333e-02	-4.32	Toll-like Receptor Signaling Pathway	WikiPathways	WP75	103	3	5310	26	PIK3CB,IRF5,PIK3R5
1.337e-02	-4.31	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	9	16828	46	ELMO1,DOCK1,RIN3,CD74,WDFY4,DOCK2,SKAP1,VAV3,DOCK10
1.339e-02	-4.31	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	49	APOE
1.339e-02	-4.31	hypoxia-inducible factor-1alpha signaling pathway	biological process	GO:0097411	5	1	18204	49	HIF1A
1.339e-02	-4.31	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	49	APOE
1.339e-02	-4.31	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	49	APOE
1.339e-02	-4.31	connective tissue replacement involved in inflammatory response wound healing	biological process	GO:0002248	5	1	18204	49	HIF1A
1.339e-02	-4.31	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031585	5	1	18204	49	P2RY6
1.339e-02	-4.31	negative regulation of filopodium assembly	biological process	GO:0051490	5	1	18204	49	PRKCD
1.339e-02	-4.31	regulation of glucosylceramide catabolic process	biological process	GO:2000752	5	1	18204	49	PRKCD
1.339e-02	-4.31	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	49	APOE
1.339e-02	-4.31	regulation of mast cell activation involved in immune response	biological process	GO:0033006	5	1	18204	49	PTPN6
1.339e-02	-4.31	positive regulation of deoxyribonuclease activity	biological process	GO:0032077	5	1	18204	49	PRKCD
1.339e-02	-4.31	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	49	APOE
1.339e-02	-4.31	ciliary neurotrophic factor-mediated signaling pathway	biological process	GO:0070120	5	1	18204	49	IL6R
1.339e-02	-4.31	response to molecule of fungal origin	biological process	GO:0002238	5	1	18204	49	SYK
1.339e-02	-4.31	epididymis development	biological process	GO:1905867	5	1	18204	49	PTPN6
1.339e-02	-4.31	positive regulation of enamel mineralization	biological process	GO:0070175	5	1	18204	49	SLC4A2
1.343e-02	-4.31	FAD-bd	interpro domains	IPR002938	5	1	18521	50	MICAL1
1.343e-02	-4.31	Gasdermin_PUB	interpro domains	IPR041263	5	1	18521	50	GSDME
1.343e-02	-4.31	Hematopoietin_rcpt_L_F3_CS	interpro domains	IPR003530	5	1	18521	50	IL6R
1.344e-02	-4.31	WNT_subtype	COSMIC cancer mutations	WNT_subtype	182	3	16828	46	WDFY4,VAV3,ELMO1
1.351e-02	-4.30	regulation of T cell differentiation	biological process	GO:0045580	185	3	18204	49	SLC4A2,CD74,SYK
1.355e-02	-4.30	SH3_9	pfam domains	PF14604	63	2	17795	50	SKAP1,ARHGAP33
1.355e-02	-4.30	phosphatase binding	molecular function	GO:0019902	188	3	18094	48	SYK,CSF1R,SKAP1
1.361e-02	-4.30	EVL (Enah/Vasp-like)	protein interactions	51466	69	2	19454	50	WAS,FYB1
1.364e-02	-4.29	G-protein beta:gamma signalling	REACTOME pathways	R-HSA-397795	51	2	10285	36	PIK3R5,PIK3CB
1.364e-02	-4.29	homotypic cell-cell adhesion	biological process	GO:0034109	66	2	18204	49	PIK3CB,PTPN6
1.364e-02	-4.29	response to ischemia	biological process	GO:0002931	66	2	18204	49	PIK3CB,CSF1R
1.364e-02	-4.29	positive regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042531	66	2	18204	49	IL6R,CSF1R
1.369e-02	-4.29	C-type lectin receptors (CLRs)	REACTOME pathways	R-HSA-5621481	144	3	10285	36	PRKCD,PLCG2,SYK
1.390e-02	-4.28	regulation of lymphocyte mediated immunity	biological process	GO:0002706	187	3	18204	49	WAS,DENND1B,PTPN6
1.397e-02	-4.27	FAD_binding_3	pfam domains	PF01494	5	1	17795	50	MICAL1
1.397e-02	-4.27	Gasdermin_C	pfam domains	PF17708	5	1	17795	50	GSDME
1.399e-02	-4.27	ITGB3 (integrin subunit beta 3)	protein interactions	3690	70	2	19454	50	P2RY2,SYK
1.404e-02	-4.27	innate immune response activating cell surface receptor signaling pathway	biological process	GO:0002220	67	2	18204	49	PLCG2,SYK
1.404e-02	-4.27	positive regulation of response to cytokine stimulus	biological process	GO:0060760	67	2	18204	49	CD74,HIF1A
1.406e-02	-4.26	regulation of response to biotic stimulus	biological process	GO:0002831	534	5	18204	49	SYK,PTPN6,APOE,GSDME,PLCG2
1.413e-02	-4.26	phosphorus metabolic process	biological process	GO:0006793	1707	10	18204	49	PTPN6,NEK6,SYK,PRKCD,ADCY7,PLCG2,PIK3CB,NRK,PIK3R5,CSF1R
1.422e-02	-4.25	Autophagy - animal	KEGG pathways	ko04140	127	3	7161	29	PIK3CB,PRKCD,HIF1A
1.422e-02	-4.25	Autophagy - animal	KEGG pathways	hsa04140	127	3	7161	29	HIF1A,PRKCD,PIK3CB
1.430e-02	-4.25	regulation of lipid biosynthetic process	biological process	GO:0046890	189	3	18204	49	PRKCD,CD74,APOE
1.430e-02	-4.25	regulation of tumor necrosis factor production	biological process	GO:0032680	189	3	18204	49	SYK,PTPN6,PLCG2
1.433e-02	-4.25	JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase)	protein interactions	23210	198	3	19454	50	WAS,DOCK1,ELMO1
1.444e-02	-4.24	CD4-positive, alpha-beta T cell activation	biological process	GO:0035710	68	2	18204	49	SEMA4A,IL6R
1.444e-02	-4.24	cell-cell recognition	biological process	GO:0009988	68	2	18204	49	DOCK2,DOCK8
1.444e-02	-4.24	parathyroid-adenoma	COSMIC cancer mutations	parathyroid-adenoma	187	3	16828	46	PLCG2,PRKCD,TBC1D8
1.463e-02	-4.22	regulation of developmental process	biological process	GO:0050793	2540	13	18204	49	SLC4A2,PTPN6,SYK,ARHGAP33,SEMA4A,CD74,PREX1,IL6R,CSF1R,PIK3CB,RGS14,HIF1A,APOE
1.468e-02	-4.22	Type II diabetes mellitus	KEGG pathways	ko04930	46	2	7161	29	PIK3CB,PRKCD
1.468e-02	-4.22	Type II diabetes mellitus	KEGG pathways	hsa04930	46	2	7161	29	PIK3CB,PRKCD
1.469e-02	-4.22	C2_NT	prosite domains	PS51840	4	1	12186	45	EHBP1L1
1.469e-02	-4.22	PI3K_ABD	prosite domains	PS51544	4	1	12186	45	PIK3CB
1.471e-02	-4.22	negative regulation of leukocyte activation	biological process	GO:0002695	191	3	18204	49	SLC4A2,PTPN6,CD74
1.472e-02	-4.22	FANCI (FA complementation group I)	protein interactions	55215	200	3	19454	50	HIF1A,P2RY6,NEK6
1.476e-02	-4.22	FANCL (FA complementation group L)	protein interactions	55120	72	2	19454	50	DOCK8,IL6R
1.476e-02	-4.22	ITGB2 (integrin subunit beta 2)	protein interactions	3689	72	2	19454	50	SYK,PRKCD
1.480e-02	-4.21	cytoskeletal protein binding	molecular function	GO:0008092	989	7	18094	48	MICAL1,APOE,WAS,RGS14,MYO1F,NEK6,PARVG
1.484e-02	-4.21	scaffold protein binding	molecular function	GO:0097110	70	2	18094	48	SYK,PLCG2
1.485e-02	-4.21	regulation of blood coagulation	biological process	GO:0030193	69	2	18204	49	APOE,PRKCD
1.497e-02	-4.20	head_neck	COSMIC cancer mutations	head_neck	15361	46	16828	46	SLC4A2,RGS14,ADCY7,GIT2,MYO1F,PTPN6,ELMO1,VAV3,PARVG,EHBP1L1,IRF5,DOCK8,DENND1B,WDFY4,PRKCD,HIF1A,DOCK1,PIK3R5,CSF1R,DOCK2,PIK3CB,WAS,PLCG2,MICAL1,TBXAS1,P2RY2,P2RY6,SYK,APOE,RIN3,GLIPR1,TBC1D8,NEK6,AKAP13,RHBDF2,IL6R,CD74,PREX1,ARHGAP27,IPCEF1,SBNO2,ARHGAP33,SEMA4A,DOCK10,GMIP,SKAP1
1.500e-02	-4.20	Signaling events mediated by focal adhesion kinase	Pathway Interaction DB	fak_pathway	54	3	2226	22	ELMO1,GIT2,DOCK1
1.508e-02	-4.19	brainstem	COSMIC cancer mutations	brainstem	3102	15	16828	46	DOCK1,SLC4A2,AKAP13,DOCK2,GIT2,PIK3CB,CSF1R,PREX1,ARHGAP27,ELMO1,PTPN6,DOCK10,WDFY4,SKAP1,VAV3
1.515e-02	-4.19	PANK4 (pantothenate kinase 4 (inactive))	protein interactions	55229	73	2	19454	50	GMIP,PTPN6
1.532e-02	-4.18	NBPF22P (NBPF member 22, pseudogene)	protein interactions	285622	6	1	19454	50	PARVG
1.532e-02	-4.18	ARMS2 (age-related maculopathy susceptibility 2)	protein interactions	387715	6	1	19454	50	MICAL1
1.532e-02	-4.18	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	50	APOE
1.532e-02	-4.18	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	50	APOE
1.532e-02	-4.18	SETD9 (SET domain containing 9)	protein interactions	133383	6	1	19454	50	PLCG2
1.532e-02	-4.18	echA1 (enoyl-CoA hydratase EchA1)	protein interactions	886723	6	1	19454	50	PTPN6
1.532e-02	-4.18	CD300LF (CD300 molecule like family member f)	protein interactions	146722	6	1	19454	50	PTPN6
1.533e-02	-4.18	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002822	194	3	18204	49	PTPN6,WAS,DENND1B
1.535e-02	-4.18	Immunoglobulin	interpro domains	IPR013151	70	2	18521	50	CSF1R,IL6R
1.535e-02	-4.18	protein serine kinase activity	molecular function	GO:0106310	362	4	18094	48	NRK,NEK6,PIK3CB,PRKCD
1.538e-02	-4.17	signaling receptor binding	molecular function	GO:0005102	1493	9	18094	48	FYB1,IL6R,VAV3,SYK,APOE,DOCK2,SEMA4A,P2RY2,CD74
1.541e-02	-4.17	glycerolipid metabolic process	biological process	GO:0046486	357	4	18204	49	PLCG2,PIK3CB,APOE,PIK3R5
1.554e-02	-4.16	regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903555	195	3	18204	49	PLCG2,SYK,PTPN6
1.554e-02	-4.16	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	2	19454	50	PLCG2,WAS
1.560e-02	-4.16	hippocampal mossy fiber	cellular component	GO:0097457	6	1	19108	50	MICAL1
1.560e-02	-4.16	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	50	APOE
1.567e-02	-4.16	regulation of hemostasis	biological process	GO:1900046	71	2	18204	49	PRKCD,APOE
1.567e-02	-4.16	lymphocyte homeostasis	biological process	GO:0002260	71	2	18204	49	HIF1A,DOCK10
1.572e-02	-4.15	TNFRSF1A (TNF receptor superfamily member 1A)	protein interactions	7132	205	3	19454	50	PTPN6,SYK,PRKCD
1.572e-02	-4.15	POLRMT (RNA polymerase mitochondrial)	protein interactions	5442	205	3	19454	50	HIF1A,SYK,SKAP1
1.581e-02	-4.15	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	48	APOE
1.585e-02	-4.14	kidney	COSMIC cancer mutations	kidney	15380	46	16828	46	SBNO2,SKAP1,GMIP,DOCK10,SEMA4A,ARHGAP33,IPCEF1,ARHGAP27,PREX1,NEK6,TBC1D8,CD74,RHBDF2,IL6R,AKAP13,P2RY6,SYK,P2RY2,RIN3,GLIPR1,APOE,MICAL1,TBXAS1,WAS,PLCG2,CSF1R,PIK3CB,DOCK2,PRKCD,DOCK1,PIK3R5,HIF1A,DENND1B,DOCK8,WDFY4,IRF5,EHBP1L1,PARVG,VAV3,ELMO1,PTPN6,MYO1F,GIT2,ADCY7,RGS14,SLC4A2
1.591e-02	-4.14	regulation of secretion by cell	biological process	GO:1903530	551	5	18204	49	HIF1A,RHBDF2,APOE,SYK,MICAL1
1.594e-02	-4.14	SPTLC2 (serine palmitoyltransferase long chain base subunit 2)	protein interactions	9517	75	2	19454	50	RIN3,P2RY6
1.597e-02	-4.14	negative regulation of immune response	biological process	GO:0050777	197	3	18204	49	SYK,PTPN6,RHBDF2
1.597e-02	-4.14	protein localization to plasma membrane	biological process	GO:0072659	197	3	18204	49	RHBDF2,FYB1,SKAP1
1.604e-02	-4.13	G13 Signaling Pathway	WikiPathways	WP524	40	2	5310	26	WAS,PIK3CB
1.604e-02	-4.13	positive regulation of nuclease activity	biological process	GO:0032075	6	1	18204	49	PRKCD
1.604e-02	-4.13	regulation of phospholipid translocation	biological process	GO:0061091	6	1	18204	49	PRKCD
1.604e-02	-4.13	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	49	APOE
1.604e-02	-4.13	positive regulation of prostaglandin biosynthetic process	biological process	GO:0031394	6	1	18204	49	CD74
1.604e-02	-4.13	regulation of establishment of T cell polarity	biological process	GO:1903903	6	1	18204	49	DOCK8
1.604e-02	-4.13	membrane raft distribution	biological process	GO:0031580	6	1	18204	49	DOCK2
1.604e-02	-4.13	hemoglobin biosynthetic process	biological process	GO:0042541	6	1	18204	49	HIF1A
1.604e-02	-4.13	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	biological process	GO:1903298	6	1	18204	49	PIK3CB
1.604e-02	-4.13	intestinal epithelial cell maturation	biological process	GO:0060574	6	1	18204	49	HIF1A
1.604e-02	-4.13	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	49	APOE
1.604e-02	-4.13	interleukin-11-mediated signaling pathway	biological process	GO:0038154	6	1	18204	49	IL6R
1.604e-02	-4.13	inositol trisphosphate metabolic process	biological process	GO:0032957	6	1	18204	49	PLCG2
1.604e-02	-4.13	osteoclast fusion	biological process	GO:0072675	6	1	18204	49	SBNO2
1.604e-02	-4.13	positive regulation of cell-cell adhesion mediated by integrin	biological process	GO:0033634	6	1	18204	49	SKAP1
1.604e-02	-4.13	elastin metabolic process	biological process	GO:0051541	6	1	18204	49	HIF1A
1.604e-02	-4.13	positive regulation of mucus secretion	biological process	GO:0070257	6	1	18204	49	P2RY2
1.604e-02	-4.13	regulation of lipid transporter activity	biological process	GO:0110112	6	1	18204	49	PRKCD
1.604e-02	-4.13	positive regulation of I-kappaB phosphorylation	biological process	GO:1903721	6	1	18204	49	PLCG2
1.604e-02	-4.13	regulation of hypoxia-induced intrinsic apoptotic signaling pathway	biological process	GO:1903297	6	1	18204	49	PIK3CB
1.604e-02	-4.13	regulation of neutrophil apoptotic process	biological process	GO:0033029	6	1	18204	49	PIK3CB
1.604e-02	-4.13	positive regulation of macrophage proliferation	biological process	GO:0120041	6	1	18204	49	CSF1R
1.604e-02	-4.13	regulation of mast cell cytokine production	biological process	GO:0032763	6	1	18204	49	SYK
1.607e-02	-4.13	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	5	16828	46	SLC4A2,CSF1R,NEK6,PRKCD,SYK
1.609e-02	-4.13	CAMSAP-like_CH_dom	interpro domains	IPR022613	6	1	18521	50	VAV3
1.609e-02	-4.13	ELMO_dom	interpro domains	IPR006816	6	1	18521	50	ELMO1
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY7
1.609e-02	-4.13	Gasdermin_pore	interpro domains	IPR040460	6	1	18521	50	GSDME
1.613e-02	-4.13	OPALIN (oligodendrocytic myelin paranodal and inner loop protein)	protein interactions	93377	207	3	19454	50	SLC4A2,RHBDF2,PRKCD
1.619e-02	-4.12	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	5	16828	46	NEK6,SYK,PRKCD,CSF1R,SLC4A2
1.635e-02	-4.11	RUNX2 (RUNX family transcription factor 2)	protein interactions	860	76	2	19454	50	PRKCD,HIF1A
1.640e-02	-4.11	positive regulation of protein-containing complex assembly	biological process	GO:0031334	199	3	18204	49	PLCG2,SKAP1,SYK
1.648e-02	-4.11	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	48	APOE
1.649e-02	-4.11	clathrin-coated endocytic vesicle membrane	cellular component	GO:0030669	75	2	19108	50	CD74,APOE
1.652e-02	-4.10	positive regulation of phagocytosis	biological process	GO:0050766	73	2	18204	49	PLCG2,DOCK2
1.652e-02	-4.10	negative regulation of wound healing	biological process	GO:0061045	73	2	18204	49	PRKCD,APOE
1.655e-02	-4.10	ig	pfam domains	PF00047	70	2	17795	50	IL6R,CSF1R
1.660e-02	-4.10	ERBB2 (erb-b2 receptor tyrosine kinase 2)	protein interactions	2064	583	5	19454	50	PLCG2,SYK,PTPN6,VAV3,PIK3CB
1.674e-02	-4.09	CAMSAP_CH	pfam domains	PF11971	6	1	17795	50	VAV3
1.674e-02	-4.09	RBD	pfam domains	PF02196	6	1	17795	50	RGS14
1.674e-02	-4.09	ELMO_CED12	pfam domains	PF04727	6	1	17795	50	ELMO1
1.674e-02	-4.09	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	50	ADCY7
1.674e-02	-4.09	Gasdermin	pfam domains	PF04598	6	1	17795	50	GSDME
1.676e-02	-4.09	DYM (dymeclin)	protein interactions	54808	77	2	19454	50	P2RY2,P2RY6
1.683e-02	-4.08	inflammatory response	biological process	GO:0006954	559	5	18204	49	HIF1A,SYK,CSF1R,IL6R,IRF5
1.695e-02	-4.08	regulation of coagulation	biological process	GO:0050818	74	2	18204	49	APOE,PRKCD
1.695e-02	-4.08	negative regulation of T cell proliferation	biological process	GO:0042130	74	2	18204	49	SLC4A2,PTPN6
1.696e-02	-4.08	HEATR1 (HEAT repeat containing 1)	protein interactions	55127	211	3	19454	50	P2RY2,P2RY6,HIF1A
1.714e-02	-4.07	positive regulation of macromolecule biosynthetic process	biological process	GO:0010557	2592	13	18204	49	CD74,HIF1A,APOE,PIK3CB,CSF1R,IL6R,SYK,IRF5,PLCG2,DENND1B,SKAP1,SBNO2,WAS
1.722e-02	-4.06	negative regulation of response to stimulus	biological process	GO:0048585	1760	10	18204	49	PTPN6,SYK,PRKCD,CD74,RHBDF2,RIN3,PIK3CB,RGS14,HIF1A,APOE
1.734e-02	-4.05	positive regulation of protein metabolic process	biological process	GO:0051247	1247	8	18204	49	PIK3R5,APOE,IL6R,CSF1R,CD74,SYK,PRKCD,PLCG2
1.738e-02	-4.05	PTK6 Expression	REACTOME pathways	R-HSA-8849473	5	1	10285	36	HIF1A
1.738e-02	-4.05	negative regulation of protein secretion	biological process	GO:0050709	75	2	18204	49	RHBDF2,APOE
1.738e-02	-4.05	phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0043491	75	2	18204	49	PIK3R5,PIK3CB
1.738e-02	-4.05	regulation of alpha-beta T cell differentiation	biological process	GO:0046637	75	2	18204	49	SYK,SLC4A2
1.742e-02	-4.05	positive regulation of response to external stimulus	biological process	GO:0032103	564	5	18204	49	SYK,CD74,CSF1R,IL6R,PLCG2
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	WAS,SYK,GIT2
1.762e-02	-4.04	cerebellum	COSMIC cancer mutations	cerebellum	769	6	16828	46	ELMO1,DOCK10,DOCK2,WDFY4,SKAP1,PIK3CB
1.782e-02	-4.03	myotube differentiation	biological process	GO:0014902	76	2	18204	49	DOCK1,DOCK2
1.782e-02	-4.03	regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042509	76	2	18204	49	IL6R,CSF1R
1.782e-02	-4.03	XPO5 (exportin 5)	protein interactions	57510	215	3	19454	50	NEK6,HIF1A,P2RY6
1.786e-02	-4.03	NSUN7 (NOP2/Sun RNA methyltransferase family member 7)	protein interactions	79730	7	1	19454	50	PTPN6
1.786e-02	-4.03	SERHL2 (serine hydrolase like 2)	protein interactions	253190	7	1	19454	50	MICAL1
1.786e-02	-4.03	HGD (homogentisate 1,2-dioxygenase)	protein interactions	3081	7	1	19454	50	GIT2
1.786e-02	-4.03	Phospho1 (phosphatase, orphan 1)	protein interactions	237928	7	1	19454	50	SLC4A2
1.786e-02	-4.03	GUCY2F (guanylate cyclase 2F, retinal)	protein interactions	2986	7	1	19454	50	MICAL1
1.786e-02	-4.03	DNAI1 (dynein axonemal intermediate chain 1)	protein interactions	27019	7	1	19454	50	HIF1A
1.786e-02	-4.03	ERCC6L2 (ERCC excision repair 6 like 2)	protein interactions	375748	7	1	19454	50	NEK6
1.786e-02	-4.03	CDHR3 (cadherin related family member 3)	protein interactions	222256	7	1	19454	50	PARVG
1.786e-02	-4.03	LAIR1 (leukocyte associated immunoglobulin like receptor 1)	protein interactions	3903	7	1	19454	50	PTPN6
1.786e-02	-4.03	KCNJ1 (potassium inwardly rectifying channel subfamily J member 1)	protein interactions	3758	7	1	19454	50	PRKCD
1.786e-02	-4.03	SIGLEC9 (sialic acid binding Ig like lectin 9)	protein interactions	27180	7	1	19454	50	PTPN6
1.804e-02	-4.01	HACD3 (3-hydroxyacyl-CoA dehydratase 3)	protein interactions	51495	216	3	19454	50	P2RY6,NEK6,RIN3
1.825e-02	-4.00	ovary	COSMIC cancer mutations	ovary	14770	45	16828	46	PARVG,EHBP1L1,IRF5,WDFY4,DOCK8,SLC4A2,RGS14,ADCY7,MYO1F,GIT2,ELMO1,PTPN6,VAV3,APOE,GLIPR1,RIN3,P2RY2,P2RY6,SYK,RHBDF2,IL6R,AKAP13,CD74,TBC1D8,NEK6,ARHGAP27,PREX1,IPCEF1,SEMA4A,DOCK10,ARHGAP33,SKAP1,GMIP,SBNO2,HIF1A,DOCK1,PIK3R5,PRKCD,PIK3CB,DOCK2,CSF1R,PLCG2,WAS,TBXAS1,MICAL1
1.827e-02	-4.00	positive regulation of small GTPase mediated signal transduction	biological process	GO:0051057	77	2	18204	49	AKAP13,PIK3CB
1.833e-02	-4.00	HEMATOPO_REC_L_F3	prosite domains	PS01354	5	1	12186	45	IL6R
1.841e-02	-3.99	IL-6 signaling pathway	WikiPathways	WP364	43	2	5310	26	PRKCD,IL6R
1.843e-02	-3.99	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	molecular function	GO:0046934	7	1	18094	48	PIK3CB
1.843e-02	-3.99	hydroperoxy icosatetraenoate dehydratase activity	molecular function	GO:0106256	7	1	18094	48	TBXAS1
1.843e-02	-3.99	MHC class II protein binding	molecular function	GO:0042289	7	1	18094	48	CD74
1.843e-02	-3.99	interleukin-6 receptor binding	molecular function	GO:0005138	7	1	18094	48	IL6R
1.843e-02	-3.99	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular function	GO:0035005	7	1	18094	48	PIK3CB
1.843e-02	-3.99	MRS2 (magnesium transporter MRS2)	protein interactions	57380	81	2	19454	50	P2RY2,GSDME
1.843e-02	-3.99	TENT5A (terminal nucleotidyltransferase 5A)	protein interactions	55603	81	2	19454	50	RIN3,SYK
1.843e-02	-3.99	KRTAP3-3 (keratin associated protein 3-3)	protein interactions	85293	81	2	19454	50	DOCK2,P2RY6
1.849e-02	-3.99	TRAF3 (TNF receptor associated factor 3)	protein interactions	7187	218	3	19454	50	PTPN6,SYK,VAV3
1.853e-02	-3.99	positive regulation of programmed cell death	biological process	GO:0043068	573	5	18204	49	GSDME,PIK3CB,PRKCD,SYK,IRF5
1.866e-02	-3.98	MAPK3 (mitogen-activated protein kinase 3)	protein interactions	5595	396	4	19454	50	HIF1A,SYK,PRKCD,RIN3
1.866e-02	-3.98	IPO5 (importin 5)	protein interactions	3843	396	4	19454	50	RIN3,P2RY6,HIF1A,DOCK8
1.866e-02	-3.98	positive regulation of canonical NF-kappaB signal transduction	biological process	GO:0043123	209	3	18204	49	NEK6,CD74,AKAP13
1.866e-02	-3.98	cell projection	cellular component	GO:0042995	2398	12	19108	50	CARMIL3,RIN3,PREX1,DOCK8,MICAL1,MYO1F,DOCK10,HIF1A,PLCG2,RGS14,APOE,ARHGAP33
1.869e-02	-3.98	positive regulation of gamma-delta T cell differentiation	biological process	GO:0045588	7	1	18204	49	SYK
1.869e-02	-3.98	regulation of arachidonic acid secretion	biological process	GO:0090237	7	1	18204	49	SYK
1.869e-02	-3.98	regulation of phospholipid catabolic process	biological process	GO:0060696	7	1	18204	49	PRKCD
1.869e-02	-3.98	regulation of macrophage proliferation	biological process	GO:0120040	7	1	18204	49	CSF1R
1.869e-02	-3.98	positive regulation of ceramide biosynthetic process	biological process	GO:2000304	7	1	18204	49	PRKCD
1.869e-02	-3.98	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	49	APOE
1.869e-02	-3.98	neural fold formation	biological process	GO:0001842	7	1	18204	49	HIF1A
1.869e-02	-3.98	positive regulation of glomerular mesangial cell proliferation	biological process	GO:0072126	7	1	18204	49	IL6R
1.869e-02	-3.98	macropinocytosis	biological process	GO:0044351	7	1	18204	49	DOCK2
1.869e-02	-3.98	wound healing involved in inflammatory response	biological process	GO:0002246	7	1	18204	49	HIF1A
1.869e-02	-3.98	positive regulation of activation of Janus kinase activity	biological process	GO:0010536	7	1	18204	49	IL6R
1.869e-02	-3.98	connective tissue replacement	biological process	GO:0097709	7	1	18204	49	HIF1A
1.869e-02	-3.98	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	49	APOE
1.869e-02	-3.98	positive regulation of interleukin-23 production	biological process	GO:0032747	7	1	18204	49	PLCG2
1.869e-02	-3.98	membrane raft localization	biological process	GO:0051665	7	1	18204	49	DOCK2
1.869e-02	-3.98	positive regulation of dendritic cell antigen processing and presentation	biological process	GO:0002606	7	1	18204	49	CD74
1.869e-02	-3.98	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	49	APOE
1.869e-02	-3.98	interleukin-3-mediated signaling pathway	biological process	GO:0038156	7	1	18204	49	SYK
1.869e-02	-3.98	positive regulation of sphingolipid biosynthetic process	biological process	GO:0090154	7	1	18204	49	PRKCD
1.869e-02	-3.98	response to yeast	biological process	GO:0001878	7	1	18204	49	PLCG2
1.869e-02	-3.98	platelet degranulation	biological process	GO:0002576	7	1	18204	49	SYK
1.872e-02	-3.98	neural crest cell development	biological process	GO:0014032	78	2	18204	49	HIF1A,SEMA4A
1.875e-02	-3.98	Vps9-like	interpro domains	IPR045046	7	1	18521	50	RIN3
1.875e-02	-3.98	PH_16	interpro domains	IPR041020	7	1	18521	50	AKAP13
1.875e-02	-3.98	RBD_dom	interpro domains	IPR003116	7	1	18521	50	RGS14
1.875e-02	-3.98	GoLoco_motif	interpro domains	IPR003109	7	1	18521	50	RGS14
1.875e-02	-3.98	Interferon_reg_factor-3	interpro domains	IPR019471	7	1	18521	50	IRF5
1.875e-02	-3.98	PI3K_Ras-bd_dom	interpro domains	IPR000341	7	1	18521	50	PIK3CB
1.875e-02	-3.98	MYSc_Myo1	interpro domains	IPR036072	7	1	18521	50	MYO1F
1.912e-02	-3.96	KRTAP10-8 (keratin associated protein 10-8)	protein interactions	386681	399	4	19454	50	ARHGAP33,NEK6,DOCK2,P2RY6
1.916e-02	-3.95	GTF3C1 (general transcription factor IIIC subunit 1)	protein interactions	2975	221	3	19454	50	SYK,SKAP1,CD74
1.942e-02	-3.94	response to virus	biological process	GO:0009615	383	4	18204	49	HIF1A,GSDME,WDFY4,IRF5
1.951e-02	-3.94	GoLoco	pfam domains	PF02188	7	1	17795	50	RGS14
1.951e-02	-3.94	PI3K_rbd	pfam domains	PF00794	7	1	17795	50	PIK3CB
1.951e-02	-3.94	PH_16	pfam domains	PF17838	7	1	17795	50	AKAP13
1.951e-02	-3.94	IRF-3	pfam domains	PF10401	7	1	17795	50	IRF5
1.961e-02	-3.93	negative regulation of transferase activity	biological process	GO:0051348	213	3	18204	49	APOE,RGS14,PRKCD
1.963e-02	-3.93	regulation of cytokine production involved in inflammatory response	biological process	GO:1900015	80	2	18204	49	HIF1A,ADCY7
1.974e-02	-3.93	PER1 (period circadian regulator 1)	protein interactions	5187	84	2	19454	50	SKAP1,HIF1A
1.974e-02	-3.93	PPARA (peroxisome proliferator activated receptor alpha)	protein interactions	5465	84	2	19454	50	PRKCD,AKAP13
1.974e-02	-3.93	PHLDB3 (pleckstrin homology like domain family B member 3)	protein interactions	653583	84	2	19454	50	SKAP1,GIT2
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	SYK,CSF1R
1.975e-02	-3.92	Pathways in cancer	KEGG pathways	hsa05200	395	5	7161	29	CSF1R,HIF1A,PLCG2,PIK3CB,ADCY7
1.983e-02	-3.92	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	18	16828	46	AKAP13,ADCY7,EHBP1L1,DOCK2,CD74,PIK3CB,IRF5,HIF1A,PIK3R5,P2RY2,SLC4A2,DOCK10,GMIP,VAV3,DOCK8,MICAL1,PREX1,ELMO1
1.984e-02	-3.92	clathrin-coated vesicle	cellular component	GO:0030136	220	3	19108	50	DENND1B,CD74,APOE
1.989e-02	-3.92	plasma membrane protein complex	cellular component	GO:0098797	600	5	19108	50	IL6R,PTPN6,CD74,SYK,SKAP1
1.990e-02	-3.92	Regulation of lipolysis in adipocytes	KEGG pathways	hsa04923	54	2	7161	29	PIK3CB,ADCY7
1.991e-02	-3.92	TCR signaling in naive CD4+ T cells	Pathway Interaction DB	tcr_pathway	60	3	2226	22	FYB1,PTPN6,WAS
1.998e-02	-3.91	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	16	16828	46	ADCY7,AKAP13,MYO1F,GIT2,DOCK2,CSF1R,HIF1A,RIN3,SLC4A2,P2RY6,PRKCD,DOCK10,ARHGAP33,WDFY4,MICAL1,PLCG2
2.008e-02	-3.91	RINT1 (RAD50 interactor 1)	protein interactions	60561	225	3	19454	50	VAV3,P2RY2,P2RY6
2.009e-02	-3.91	regulation of amide metabolic process	biological process	GO:0034248	81	2	18204	49	APOE,PRKCD
2.018e-02	-3.90	MYD88 (MYD88 innate immune signal transduction adaptor)	protein interactions	4615	85	2	19454	50	SYK,IRF5
2.032e-02	-3.90	endosome	cellular component	GO:0005768	1067	7	19108	50	CD74,APOE,WDFY4,PRKCD,MICAL1,EHBP1L1,RIN3
2.038e-02	-3.89	Adaptive Immune System	REACTOME pathways	R-HSA-1280218	810	7	10285	36	CD74,PTPN6,PLCG2,FYB1,PIK3CB,WAS,SYK
2.038e-02	-3.89	SRARP (steroid receptor associated and regulated protein)	protein interactions	149563	8	1	19454	50	SLC4A2
2.038e-02	-3.89	Marcks (myristoylated alanine rich protein kinase C substrate)	protein interactions	17118	8	1	19454	50	PRKCD
2.038e-02	-3.89	HIF3A (hypoxia inducible factor 3 subunit alpha)	protein interactions	64344	8	1	19454	50	HIF1A
2.038e-02	-3.89	SSX4 (SSX family member 4)	protein interactions	6759	8	1	19454	50	HIF1A
2.038e-02	-3.89	vIRF-3 (vIRF-3)	protein interactions	4961493	8	1	19454	50	HIF1A
2.038e-02	-3.89	LILRB1 (leukocyte immunoglobulin like receptor B1)	protein interactions	10859	8	1	19454	50	PTPN6
2.038e-02	-3.89	RNPEPL1 (arginyl aminopeptidase like 1)	protein interactions	57140	8	1	19454	50	RIN3
2.038e-02	-3.89	DZANK1 (double zinc ribbon and ankyrin repeat domains 1)	protein interactions	55184	8	1	19454	50	GLIPR1
2.038e-02	-3.89	Prkca (protein kinase C, alpha)	protein interactions	24680	8	1	19454	50	AKAP13
2.038e-02	-3.89	CD1D (CD1d molecule)	protein interactions	912	8	1	19454	50	CD74
2.038e-02	-3.89	OR5H1 (olfactory receptor family 5 subfamily H member 1)	protein interactions	26341	8	1	19454	50	SLC4A2
2.038e-02	-3.89	TREML1 (triggering receptor expressed on myeloid cells like 1)	protein interactions	340205	8	1	19454	50	PTPN6
2.082e-02	-3.87	PTK6 promotes HIF1A stabilization	REACTOME pathways	R-HSA-8857538	6	1	10285	36	HIF1A
2.082e-02	-3.87	CD22 mediated BCR regulation	REACTOME pathways	R-HSA-5690714	6	1	10285	36	PTPN6
2.092e-02	-3.87	cellular localization	biological process	GO:0051641	2660	13	18204	49	HIF1A,APOE,RGS14,RHBDF2,CD74,DOCK2,ARHGAP33,SKAP1,WAS,FYB1,GIT2,SYK,DENND1B
2.103e-02	-3.86	CD4 receptor binding	molecular function	GO:0042609	8	1	18094	48	CD74
2.103e-02	-3.86	transcription regulator activator activity	molecular function	GO:0140537	8	1	18094	48	HIF1A
2.103e-02	-3.86	adenosine receptor binding	molecular function	GO:0031685	8	1	18094	48	P2RY2
2.108e-02	-3.86	CMTM6 (CKLF like MARVEL transmembrane domain containing 6)	protein interactions	54918	87	2	19454	50	GLIPR1,P2RY2
2.108e-02	-3.86	FGR (FGR proto-oncogene, Src family tyrosine kinase)	protein interactions	2268	87	2	19454	50	WAS,SYK
2.115e-02	-3.86	supramolecular fiber organization	biological process	GO:0097435	593	5	18204	49	PREX1,MICAL1,ELMO1,WAS,MYO1F
2.119e-02	-3.85	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	7	18204	49	SBNO2,HIF1A,P2RY6,PLCG2,P2RY2,ADCY7,PRKCD
2.128e-02	-3.85	neuron projection	cellular component	GO:0043005	1331	8	19108	50	RGS14,APOE,ARHGAP33,PREX1,HIF1A,DOCK10,RIN3,MICAL1
2.134e-02	-3.85	positive regulation of tooth mineralization	biological process	GO:0070172	8	1	18204	49	SLC4A2
2.134e-02	-3.85	regulation of CD8-positive, alpha-beta T cell proliferation	biological process	GO:2000564	8	1	18204	49	SLC4A2
2.134e-02	-3.85	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	49	APOE
2.134e-02	-3.85	cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:0036006	8	1	18204	49	CSF1R
2.134e-02	-3.85	regulation of mast cell chemotaxis	biological process	GO:0060753	8	1	18204	49	RIN3
2.134e-02	-3.85	regulation of I-kappaB phosphorylation	biological process	GO:1903719	8	1	18204	49	PLCG2
2.134e-02	-3.85	regulation of CD8-positive, alpha-beta T cell differentiation	biological process	GO:0043376	8	1	18204	49	SLC4A2
2.134e-02	-3.85	regulation of transforming growth factor beta2 production	biological process	GO:0032909	8	1	18204	49	HIF1A
2.134e-02	-3.85	regulation of neutrophil degranulation	biological process	GO:0043313	8	1	18204	49	SYK
2.134e-02	-3.85	positive regulation of killing of cells of another organism	biological process	GO:0051712	8	1	18204	49	SYK
2.134e-02	-3.85	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	49	APOE
2.134e-02	-3.85	positive regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001280	8	1	18204	49	CD74
2.134e-02	-3.85	multinuclear osteoclast differentiation	biological process	GO:0072674	8	1	18204	49	SBNO2
2.134e-02	-3.85	embryonic cleavage	biological process	GO:0040016	8	1	18204	49	PIK3CB
2.134e-02	-3.85	protein import	biological process	GO:0017038	8	1	18204	49	APOE
2.134e-02	-3.85	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	49	APOE
2.134e-02	-3.85	negative regulation of CD8-positive, alpha-beta T cell activation	biological process	GO:2001186	8	1	18204	49	SLC4A2
2.134e-02	-3.85	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	49	APOE
2.134e-02	-3.85	intracellular oxygen homeostasis	biological process	GO:0032364	8	1	18204	49	HIF1A
2.134e-02	-3.85	mitotic nuclear membrane disassembly	biological process	GO:0007077	8	1	18204	49	NEK6
2.134e-02	-3.85	G protein-coupled receptor signaling pathway involved in heart process	biological process	GO:0086103	8	1	18204	49	AKAP13
2.134e-02	-3.85	regulation of enamel mineralization	biological process	GO:0070173	8	1	18204	49	SLC4A2
2.134e-02	-3.85	regulation of activation of Janus kinase activity	biological process	GO:0010533	8	1	18204	49	IL6R
2.134e-02	-3.85	regulation of endodeoxyribonuclease activity	biological process	GO:0032071	8	1	18204	49	PRKCD
2.139e-02	-3.84	antioxidant activity	molecular function	GO:0016209	85	2	18094	48	IPCEF1,APOE
2.140e-02	-3.84	TypeI_recpt_CBD	interpro domains	IPR015321	8	1	18521	50	IL6R
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY7
2.140e-02	-3.84	PH-BEACH_dom	interpro domains	IPR023362	8	1	18521	50	WDFY4
2.140e-02	-3.84	Tyr_kinase_rcpt_3_CS	interpro domains	IPR001824	8	1	18521	50	CSF1R
2.140e-02	-3.84	PI3K-type_C2_dom	interpro domains	IPR002420	8	1	18521	50	PIK3CB
2.140e-02	-3.84	Myosin_TH1	interpro domains	IPR010926	8	1	18521	50	MYO1F
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY7
2.151e-02	-3.84	stem cell development	biological process	GO:0048864	84	2	18204	49	HIF1A,SEMA4A
2.151e-02	-3.84	regulation of release of sequestered calcium ion into cytosol	biological process	GO:0051279	84	2	18204	49	P2RY6,PTPN6
2.165e-02	-3.83	negative regulation of cell motility	biological process	GO:2000146	396	4	18204	49	WAS,RIN3,CD74,APOE
2.166e-02	-3.83	haematopoietic_and_lymphoid_tissue-other-normal	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-other-normal	8	1	16828	46	CSF1R
2.170e-02	-3.83	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	27	16828	46	DOCK8,SBNO2,SKAP1,WDFY4,DOCK10,IPCEF1,ARHGAP27,PREX1,EHBP1L1,AKAP13,PARVG,RIN3,GLIPR1,MICAL1,VAV3,TBXAS1,ELMO1,WAS,PIK3CB,MYO1F,DOCK2,GIT2,RGS14,SLC4A2,PIK3R5,DOCK1,HIF1A
2.175e-02	-3.83	Ion Channel and Phorbal Esters Signaling Pathway	SMPDB pathways	SMP0090032	5	1	1369	6	P2RY2
2.195e-02	-3.82	somatodendritic compartment	cellular component	GO:0036477	842	6	19108	50	PREX1,RGS14,ARHGAP33,APOE,DOCK10,RIN3
2.196e-02	-3.82	ELMO	prosite domains	PS51335	6	1	12186	45	ELMO1
2.199e-02	-3.82	INSRR (insulin receptor related receptor)	protein interactions	3645	89	2	19454	50	RHBDF2,PRKCD
2.199e-02	-3.82	FCER1G (Fc epsilon receptor Ig)	protein interactions	2207	89	2	19454	50	SYK,PLCG2
2.215e-02	-3.81	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	9	16828	46	RIN3,DOCK1,ELMO1,VAV3,SKAP1,WDFY4,CD74,DOCK2,DOCK10
2.224e-02	-3.81	JAK1 (Janus kinase 1)	protein interactions	3716	234	3	19454	50	SYK,PTPN6,PLCG2
2.226e-02	-3.80	PI3K_C2	pfam domains	PF00792	8	1	17795	50	PIK3CB
2.226e-02	-3.80	AC_N	pfam domains	PF16214	8	1	17795	50	ADCY7
2.226e-02	-3.80	Myosin_TH1	pfam domains	PF06017	8	1	17795	50	MYO1F
2.226e-02	-3.80	IL6Ra-bind	pfam domains	PF09240	8	1	17795	50	IL6R
2.241e-02	-3.80	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	8	16828	46	PTPN6,GLIPR1,DOCK1,ARHGAP27,PLCG2,PREX1,DOCK2,ADCY7
2.246e-02	-3.80	IPO13 (importin 13)	protein interactions	9670	90	2	19454	50	CD74,P2RY6
2.247e-02	-3.80	positive regulation of lipid transport	biological process	GO:0032370	86	2	18204	49	APOE,PRKCD
2.258e-02	-3.79	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	5	14470	48	CSF1R,NRK,NEK6,PRKCD,SYK
2.262e-02	-3.79	striated muscle cell differentiation	biological process	GO:0051146	225	3	18204	49	AKAP13,DOCK1,DOCK2
2.265e-02	-3.79	Differentiation Pathway	WikiPathways	WP2848	48	2	5310	26	CSF1R,IL6R
2.272e-02	-3.78	human chr6q25.2	chromosome location	human chr6q25.2	12	1	26134	50	IPCEF1
2.276e-02	-3.78	Non-small cell lung cancer	KEGG pathways	ko05223	58	2	7161	29	PLCG2,PIK3CB
2.276e-02	-3.78	Non-small cell lung cancer	KEGG pathways	hsa05223	58	2	7161	29	PLCG2,PIK3CB
2.286e-02	-3.78	nuclear speck	cellular component	GO:0016607	414	4	19108	50	NEK6,DENND1B,HIF1A,DOCK1
2.288e-02	-3.78	anatomical structure development	biological process	GO:0048856	5207	21	18204	49	SYK,PTPN6,DOCK1,DOCK10,GIT2,GSDME,PLCG2,SLC4A2,WAS,VAV3,SBNO2,SEMA4A,DOCK2,PREX1,CD74,AKAP13,PIK3CB,APOE,HIF1A,IL6R,CSF1R
2.290e-02	-3.78	CASS4 (Cas scaffold protein family member 4)	protein interactions	57091	9	1	19454	50	MICAL1
2.290e-02	-3.78	ADCY7 (adenylate cyclase 7)	protein interactions	113	9	1	19454	50	PRKCD
2.290e-02	-3.78	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	50	APOE
2.290e-02	-3.78	RWDD3 (RWD domain containing 3)	protein interactions	25950	9	1	19454	50	HIF1A
2.290e-02	-3.78	DUX3 (double homeobox 3)	protein interactions	26582	9	1	19454	50	PRKCD
2.290e-02	-3.78	ARHGAP33 (Rho GTPase activating protein 33)	protein interactions	115703	9	1	19454	50	NEK6
2.290e-02	-3.78	HLA-DMA (major histocompatibility complex, class II, DM alpha)	protein interactions	3108	9	1	19454	50	CD74
2.290e-02	-3.78	LILRB2 (leukocyte immunoglobulin like receptor B2)	protein interactions	10288	9	1	19454	50	PTPN6
2.290e-02	-3.78	PEAR1 (platelet endothelial aggregation receptor 1)	protein interactions	375033	9	1	19454	50	SYK
2.290e-02	-3.78	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	50	APOE
2.292e-02	-3.78	KDELR1 (KDEL endoplasmic reticulum protein retention receptor 1)	protein interactions	10945	91	2	19454	50	P2RY2,NEK6
2.296e-02	-3.77	modulation by host of symbiont process	biological process	GO:0051851	87	2	18204	49	APOE,CSF1R
2.296e-02	-3.77	associative learning	biological process	GO:0008306	87	2	18204	49	HIF1A,RGS14
2.299e-02	-3.77	PPP6R3 (protein phosphatase 6 regulatory subunit 3)	protein interactions	55291	237	3	19454	50	CD74,P2RY6,IRF5
2.305e-02	-3.77	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	37	16828	46	P2RY2,PARVG,P2RY6,SYK,RIN3,TBC1D8,NEK6,RHBDF2,EHBP1L1,AKAP13,IRF5,CD74,PREX1,IPCEF1,DOCK8,DOCK10,ARHGAP33,SKAP1,GMIP,WDFY4,SLC4A2,PRKCD,HIF1A,DOCK1,PIK3R5,CSF1R,ADCY7,PIK3CB,MYO1F,DOCK2,GIT2,ELMO1,PTPN6,PLCG2,MICAL1,TBXAS1,VAV3
2.331e-02	-3.76	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	48	APOE,CD74
2.331e-02	-3.76	unconventional myosin complex	cellular component	GO:0016461	9	1	19108	50	MYO1F
2.339e-02	-3.76	MLEC (malectin)	protein interactions	9761	92	2	19454	50	RIN3,P2RY6
2.339e-02	-3.76	ARHGEF16 (Rho guanine nucleotide exchange factor 16)	protein interactions	27237	92	2	19454	50	ELMO1,PRKCD
2.346e-02	-3.75	astrocytoma_Grade_II	COSMIC cancer mutations	astrocytoma_Grade_II	601	5	16828	46	PREX1,PIK3CB,WDFY4,RGS14,SBNO2
2.350e-02	-3.75	VEGF signaling pathway	KEGG pathways	hsa04370	59	2	7161	29	PIK3CB,PLCG2
2.350e-02	-3.75	VEGF signaling pathway	KEGG pathways	ko04370	59	2	7161	29	PLCG2,PIK3CB
2.355e-02	-3.75	IL-3 Signaling Pathway	WikiPathways	WP286	49	2	5310	26	PTPN6,SYK
2.363e-02	-3.75	NAD(P)H oxidase H2O2-forming activity	molecular function	GO:0016174	9	1	18094	48	MICAL1
2.368e-02	-3.74	regulation of plasma membrane bounded cell projection assembly	biological process	GO:0120032	229	3	18204	49	WAS,TBC1D8,PRKCD
2.384e-02	-3.74	STAT3 (signal transducer and activator of transcription 3)	protein interactions	6774	427	4	19454	50	PRKCD,HIF1A,SYK,IL6R
2.385e-02	-3.74	PI3K_rbd	smart domains	SM00144	6	1	9717	39	PIK3CB
2.387e-02	-3.74	USP25 (ubiquitin specific peptidase 25)	protein interactions	29761	93	2	19454	50	HIF1A,SYK
2.395e-02	-3.73	negative regulation of lymphocyte proliferation	biological process	GO:0050672	89	2	18204	49	SLC4A2,PTPN6
2.397e-02	-3.73	microglial cell proliferation	biological process	GO:0061518	9	1	18204	49	CSF1R
2.397e-02	-3.73	positive regulation of myeloid cell apoptotic process	biological process	GO:0033034	9	1	18204	49	PIK3CB
2.397e-02	-3.73	iris morphogenesis	biological process	GO:0061072	9	1	18204	49	HIF1A
2.397e-02	-3.73	positive regulation of T-helper 2 cell cytokine production	biological process	GO:2000553	9	1	18204	49	DENND1B
2.397e-02	-3.73	regulation of gamma-delta T cell differentiation	biological process	GO:0045586	9	1	18204	49	SYK
2.397e-02	-3.73	negative regulation of inflammatory response to wounding	biological process	GO:0106015	9	1	18204	49	PTPN6
2.397e-02	-3.73	sterol catabolic process	biological process	GO:0016127	9	1	18204	49	APOE
2.397e-02	-3.73	negative regulation of thymocyte apoptotic process	biological process	GO:0070244	9	1	18204	49	HIF1A
2.397e-02	-3.73	regulation of killing of cells of another organism	biological process	GO:0051709	9	1	18204	49	SYK
2.397e-02	-3.73	positive regulation of antigen processing and presentation	biological process	GO:0002579	9	1	18204	49	CD74
2.397e-02	-3.73	transepithelial chloride transport	biological process	GO:0030321	9	1	18204	49	P2RY6
2.397e-02	-3.73	macrophage proliferation	biological process	GO:0061517	9	1	18204	49	CSF1R
2.397e-02	-3.73	establishment of T cell polarity	biological process	GO:0001768	9	1	18204	49	DOCK2
2.397e-02	-3.73	positive regulation of gamma-delta T cell activation	biological process	GO:0046645	9	1	18204	49	SYK
2.397e-02	-3.73	positive regulation of cell proliferation involved in kidney development	biological process	GO:1901724	9	1	18204	49	IL6R
2.397e-02	-3.73	cellular response to hydroperoxide	biological process	GO:0071447	9	1	18204	49	PRKCD
2.397e-02	-3.73	positive regulation of hormone biosynthetic process	biological process	GO:0046886	9	1	18204	49	HIF1A
2.397e-02	-3.73	cyclooxygenase pathway	biological process	GO:0019371	9	1	18204	49	TBXAS1
2.397e-02	-3.73	T-helper 17 cell lineage commitment	biological process	GO:0072540	9	1	18204	49	IL6R
2.397e-02	-3.73	regulation of mucus secretion	biological process	GO:0070255	9	1	18204	49	P2RY2
2.397e-02	-3.73	gamma-delta T cell differentiation	biological process	GO:0042492	9	1	18204	49	SYK
2.397e-02	-3.73	Cdc42 protein signal transduction	biological process	GO:0032488	9	1	18204	49	WAS
2.397e-02	-3.73	glandular epithelial cell maturation	biological process	GO:0002071	9	1	18204	49	HIF1A
2.397e-02	-3.73	marginal zone B cell differentiation	biological process	GO:0002315	9	1	18204	49	DOCK10
2.397e-02	-3.73	regulation of sarcomere organization	biological process	GO:0060297	9	1	18204	49	AKAP13
2.397e-02	-3.73	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	49	APOE
2.402e-02	-3.73	HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta)	protein interactions	3032	428	4	19454	50	SYK,P2RY6,APOE,CD74
2.404e-02	-3.73	Interferon_reg_fac_CS	interpro domains	IPR019817	9	1	18521	50	IRF5
2.404e-02	-3.73	BEACH_dom_sf	interpro domains	IPR036372	9	1	18521	50	WDFY4
2.404e-02	-3.73	Peptidase_S54_rhomboid_dom	interpro domains	IPR022764	9	1	18521	50	RHBDF2
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A2
2.404e-02	-3.73	Interferon_reg_fact_DNA-bd_dom	interpro domains	IPR001346	9	1	18521	50	IRF5
2.404e-02	-3.73	PI3K_accessory_sf	interpro domains	IPR042236	9	1	18521	50	PIK3CB
2.404e-02	-3.73	BEACH_dom	interpro domains	IPR000409	9	1	18521	50	WDFY4
2.413e-02	-3.72	Interferon alpha/beta signaling	REACTOME pathways	R-HSA-909733	69	2	10285	36	IRF5,PTPN6
2.422e-02	-3.72	regulation of cell projection assembly	biological process	GO:0060491	231	3	18204	49	TBC1D8,PRKCD,WAS
2.425e-02	-3.72	Activation of NIMA Kinases NEK9, NEK6, NEK7	REACTOME pathways	R-HSA-2980767	7	1	10285	36	NEK6
2.430e-02	-3.72	protein binding	molecular function	GO:0005515	13983	43	18094	48	APOE,DOCK2,ARHGAP27,DOCK1,TBC1D8,GSDME,DOCK8,RGS14,MYO1F,HIF1A,PRKCD,DOCK10,SEMA4A,PLCG2,P2RY6,GIT2,SLC4A2,GMIP,CD74,WAS,IRF5,PIK3CB,FYB1,CSF1R,RHBDF2,GLIPR1,PARVG,IL6R,SKAP1,ARHGAP33,PREX1,PTPN6,NEK6,ELMO1,SYK,VAV3,DENND1B,RIN3,SBNO2,P2RY2,AKAP13,MICAL1,IPCEF1
2.435e-02	-3.72	NUAK1 (NUAK family kinase 1)	protein interactions	9891	94	2	19454	50	ELMO1,DOCK1
2.435e-02	-3.72	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	50	ELMO1,DOCK1
2.435e-02	-3.72	ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase)	protein interactions	6098	94	2	19454	50	VAV3,PTPN6
2.436e-02	-3.71	regulation of cell development	biological process	GO:0060284	839	6	18204	49	HIF1A,RGS14,SYK,PTPN6,CD74,SLC4A2
2.439e-02	-3.71	EGF receptor (ErbB1) signaling pathway	Pathway Interaction DB	erbb1_receptor_proximal_pathway	25	2	2226	22	PTPN6,PIK3CB
2.446e-02	-3.71	regulation of Rho protein signal transduction	biological process	GO:0035023	90	2	18204	49	AKAP13,APOE
2.448e-02	-3.71	Jak-STAT signaling pathway	KEGG pathways	hsa04630	156	3	7161	29	PTPN6,IL6R,PIK3CB
2.448e-02	-3.71	Jak-STAT signaling pathway	KEGG pathways	ko04630	156	3	7161	29	PTPN6,IL6R,PIK3CB
2.462e-02	-3.70	LPA receptor mediated events	Pathway Interaction DB	lysophospholipid_pathway	65	3	2226	22	PIK3CB,ADCY7,PRKCD
2.468e-02	-3.70	clathrin-coated endocytic vesicle	cellular component	GO:0045334	93	2	19108	50	CD74,APOE
2.480e-02	-3.70	negative regulation of locomotion	biological process	GO:0040013	413	4	18204	49	CD74,APOE,RIN3,WAS
2.496e-02	-3.69	negative regulation of mononuclear cell proliferation	biological process	GO:0032945	91	2	18204	49	SLC4A2,PTPN6
2.496e-02	-3.69	neural crest cell differentiation	biological process	GO:0014033	91	2	18204	49	HIF1A,SEMA4A
2.496e-02	-3.69	cellular oxidant detoxification	biological process	GO:0098869	91	2	18204	49	IPCEF1,APOE
2.501e-02	-3.69	Beach	pfam domains	PF02138	9	1	17795	50	WDFY4
2.501e-02	-3.69	PI3Ka	pfam domains	PF00613	9	1	17795	50	PIK3CB
2.501e-02	-3.69	Rhomboid	pfam domains	PF01694	9	1	17795	50	RHBDF2
2.501e-02	-3.69	Band_3_cyto	pfam domains	PF07565	9	1	17795	50	SLC4A2
2.501e-02	-3.69	IRF	pfam domains	PF00605	9	1	17795	50	IRF5
2.530e-02	-3.68	protein transport	biological process	GO:0015031	1086	7	18204	49	HIF1A,APOE,RHBDF2,CD74,SYK,ARHGAP33,DENND1B
2.532e-02	-3.68	KCTD5 (potassium channel tetramerization domain containing 5)	protein interactions	54442	96	2	19454	50	NEK6,GIT2
2.532e-02	-3.68	LMAN2 (lectin, mannose binding 2)	protein interactions	10960	96	2	19454	50	P2RY6,SLC4A2
2.538e-02	-3.67	Hepatitis C and Hepatocellular Carcinoma	WikiPathways	WP3646	51	2	5310	26	IL6R,HIF1A
2.541e-02	-3.67	SIGLEC10 (sialic acid binding Ig like lectin 10)	protein interactions	89790	10	1	19454	50	PTPN6
2.541e-02	-3.67	IPCEF1 (interaction protein for cytohesin exchange factors 1)	protein interactions	26034	10	1	19454	50	DOCK1
2.541e-02	-3.67	IL11 (interleukin 11)	protein interactions	3589	10	1	19454	50	HIF1A
2.541e-02	-3.67	RAB37 (RAB37, member RAS oncogene family)	protein interactions	326624	10	1	19454	50	MICAL1
2.541e-02	-3.67	PGA4 (pepsinogen A4)	protein interactions	643847	10	1	19454	50	CD74
2.541e-02	-3.67	GPLD1 (glycosylphosphatidylinositol specific phospholipase D1)	protein interactions	2822	10	1	19454	50	HIF1A
2.541e-02	-3.67	SIGLEC7 (sialic acid binding Ig like lectin 7)	protein interactions	27036	10	1	19454	50	PTPN6
2.548e-02	-3.67	positive regulation of transporter activity	biological process	GO:0032411	92	2	18204	49	P2RY6,PRKCD
2.548e-02	-3.67	positive regulation of mononuclear cell migration	biological process	GO:0071677	92	2	18204	49	CSF1R,DOCK8
2.551e-02	-3.67	lipid binding	molecular function	GO:0008289	861	6	18094	48	FYB1,DENND1B,APOE,PREX1,ARHGAP33,GSDME
2.557e-02	-3.67	CRISP_1	prosite domains	PS01009	7	1	12186	45	GLIPR1
2.557e-02	-3.67	PI3K_RBD	prosite domains	PS51546	7	1	12186	45	PIK3CB
2.557e-02	-3.67	GOLOCO	prosite domains	PS50877	7	1	12186	45	RGS14
2.557e-02	-3.67	RBD	prosite domains	PS50898	7	1	12186	45	RGS14
2.563e-02	-3.66	BCR signaling pathway	Pathway Interaction DB	bcr_5pathway	66	3	2226	22	PLCG2,PTPN6,SYK
2.577e-02	-3.66	Longevity regulating pathway - multiple species	KEGG pathways	hsa04213	62	2	7161	29	PIK3CB,ADCY7
2.577e-02	-3.66	Longevity regulating pathway - multiple species	KEGG pathways	ko04213	62	2	7161	29	PIK3CB,ADCY7
2.578e-02	-3.66	blood circulation	biological process	GO:0008015	418	4	18204	49	TBC1D8,APOE,TBXAS1,P2RY2
2.581e-02	-3.66	alveolar	COSMIC cancer mutations	alveolar	2414	12	16828	46	SLC4A2,DOCK1,GLIPR1,APOE,PLCG2,MICAL1,CSF1R,SBNO2,TBC1D8,VAV3,WDFY4,AKAP13
2.581e-02	-3.66	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	12	16828	46	APOE,GLIPR1,DOCK1,SLC4A2,AKAP13,TBC1D8,CSF1R,PLCG2,WDFY4,VAV3,SBNO2,MICAL1
2.585e-02	-3.66	SYK (spleen associated tyrosine kinase)	protein interactions	6850	248	3	19454	50	SYK,PTPN6,PLCG2
2.585e-02	-3.66	MET (MET proto-oncogene, receptor tyrosine kinase)	protein interactions	4233	248	3	19454	50	SYK,PLCG2,VAV3
2.587e-02	-3.65	immunoglobulin complex	cellular component	GO:0019814	10	1	19108	50	SYK
2.606e-02	-3.65	Succinate Signalling	SMPDB pathways	SMP0083294	6	1	1369	6	HIF1A
2.612e-02	-3.65	NUP93 (nucleoporin 93)	protein interactions	9688	249	3	19454	50	NEK6,HIF1A,RIN3
2.616e-02	-3.64	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	49	RHBDF2,FYB1,SKAP1
2.622e-02	-3.64	1-phosphatidylinositol-3-kinase activity	molecular function	GO:0016303	10	1	18094	48	PIK3CB
2.631e-02	-3.64	NUDT16L1 (nudix hydrolase 16 like 1)	protein interactions	84309	98	2	19454	50	RIN3,NEK6
2.631e-02	-3.64	GNAO1 (G protein subunit alpha o1)	protein interactions	2775	98	2	19454	50	RGS14,MICAL1
2.644e-02	-3.63	RHOQ (ras homolog family member Q)	protein interactions	23433	441	4	19454	50	GIT2,DOCK8,SLC4A2,WAS
2.646e-02	-3.63	human chr9q22.2	chromosome location	human chr9q22.2	14	1	26134	50	SYK
2.651e-02	-3.63	protein serine/threonine kinase activity	molecular function	GO:0004674	428	4	18094	48	NRK,PRKCD,NEK6,SYK
2.651e-02	-3.63	regulation of calcium-mediated signaling	biological process	GO:0050848	94	2	18204	49	SYK,PLCG2
2.660e-02	-3.63	establishment of lymphocyte polarity	biological process	GO:0001767	10	1	18204	49	DOCK2
2.660e-02	-3.63	regulation of deoxyribonuclease activity	biological process	GO:0032070	10	1	18204	49	PRKCD
2.660e-02	-3.63	negative regulation of mast cell activation	biological process	GO:0033004	10	1	18204	49	PTPN6
2.660e-02	-3.63	negative regulation of cellular response to hypoxia	biological process	GO:1900038	10	1	18204	49	PIK3CB
2.660e-02	-3.63	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	49	ADCY7
2.660e-02	-3.63	hemoglobin metabolic process	biological process	GO:0020027	10	1	18204	49	HIF1A
2.660e-02	-3.63	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	49	APOE
2.660e-02	-3.63	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	49	APOE
2.660e-02	-3.63	intracellular chloride ion homeostasis	biological process	GO:0030644	10	1	18204	49	TBXAS1
2.660e-02	-3.63	negative regulation of glial cell apoptotic process	biological process	GO:0034351	10	1	18204	49	PRKCD
2.660e-02	-3.63	regulation of interleukin-23 production	biological process	GO:0032667	10	1	18204	49	PLCG2
2.660e-02	-3.63	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	49	APOE
2.660e-02	-3.63	positive regulation of monocyte differentiation	biological process	GO:0045657	10	1	18204	49	CD74
2.660e-02	-3.63	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	49	APOE
2.660e-02	-3.63	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	49	APOE
2.660e-02	-3.63	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	49	APOE
2.660e-02	-3.63	intracellular monoatomic anion homeostasis	biological process	GO:0030002	10	1	18204	49	TBXAS1
2.660e-02	-3.63	positive regulation of Rac protein signal transduction	biological process	GO:0035022	10	1	18204	49	PIK3CB
2.668e-02	-3.62	VPS9_dom_sf	interpro domains	IPR037191	10	1	18521	50	RIN3
2.668e-02	-3.62	PI3K_accessory_dom	interpro domains	IPR001263	10	1	18521	50	PIK3CB
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	HIF1A
2.668e-02	-3.62	PI_Kinase	interpro domains	IPR015433	10	1	18521	50	PIK3CB
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A2
2.668e-02	-3.62	VPS9	interpro domains	IPR003123	10	1	18521	50	RIN3
2.668e-02	-3.62	Allrgn_V5/Tpx1_CS	interpro domains	IPR018244	10	1	18521	50	GLIPR1
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A2
2.668e-02	-3.62	CRIB_dom_sf	interpro domains	IPR036936	10	1	18521	50	WAS
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A2
2.680e-02	-3.62	XPO4 (exportin 4)	protein interactions	64328	99	2	19454	50	P2RY6,P2RY2
2.693e-02	-3.61	CXCR4 (C-X-C motif chemokine receptor 4)	protein interactions	7852	252	3	19454	50	PTPN6,HIF1A,PIK3CB
2.693e-02	-3.61	PSMD7 (proteasome 26S subunit, non-ATPase 7)	protein interactions	5713	252	3	19454	50	PREX1,P2RY6,PTPN6
2.693e-02	-3.61	CSDE1 (cold shock domain containing E1)	protein interactions	7812	252	3	19454	50	RIN3,RHBDF2,P2RY6
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	CSF1R,SYK
2.730e-02	-3.60	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	6	16828	46	DOCK2,VAV3,SEMA4A,ELMO1,NEK6,DOCK8
2.731e-02	-3.60	MUL1 (mitochondrial E3 ubiquitin protein ligase 1)	protein interactions	79594	100	2	19454	50	GSDME,TBC1D8
2.731e-02	-3.60	SKAP1 (src kinase associated phosphoprotein 1)	protein interactions	8631	100	2	19454	50	FYB1,SKAP1
2.734e-02	-3.60	Glioma	KEGG pathways	hsa05214	64	2	7161	29	PIK3CB,PLCG2
2.734e-02	-3.60	Renal cell carcinoma	KEGG pathways	hsa05211	64	2	7161	29	HIF1A,PIK3CB
2.734e-02	-3.60	Renal cell carcinoma	KEGG pathways	ko05211	64	2	7161	29	PIK3CB,HIF1A
2.734e-02	-3.60	Glioma	KEGG pathways	ko05214	64	2	7161	29	PLCG2,PIK3CB
2.735e-02	-3.60	cytokine receptor activity	molecular function	GO:0004896	97	2	18094	48	CD74,IL6R
2.736e-02	-3.60	pleura	COSMIC cancer mutations	pleura	4914	20	16828	46	IRF5,PIK3CB,GIT2,IL6R,AKAP13,NEK6,CSF1R,PIK3R5,DOCK1,HIF1A,SYK,PRKCD,RGS14,VAV3,SEMA4A,ARHGAP33,PREX1,PLCG2,PTPN6,WAS
2.738e-02	-3.60	central_nervous_system-brain-glioma-astrocytoma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_II	420	4	16828	46	WDFY4,PREX1,RGS14,SBNO2
2.756e-02	-3.59	immunoglobulin mediated immune response	biological process	GO:0016064	96	2	18204	49	CD74,PRKCD
2.765e-02	-3.59	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	18	16828	46	PREX1,ELMO1,ARHGAP33,DOCK10,WDFY4,GMIP,VAV3,DOCK8,PIK3R5,DOCK1,RIN3,P2RY2,AKAP13,RHBDF2,DOCK2,MYO1F,TBC1D8,CSF1R
2.767e-02	-3.59	HuR (ELAVL1) binds and stabilizes mRNA	REACTOME pathways	R-HSA-450520	8	1	10285	36	PRKCD
2.771e-02	-3.59	actin binding	molecular function	GO:0003779	434	4	18094	48	MICAL1,WAS,PARVG,MYO1F
2.775e-02	-3.58	VPS9	pfam domains	PF02204	10	1	17795	50	RIN3
2.775e-02	-3.58	HCO3_cotransp	pfam domains	PF00955	10	1	17795	50	SLC4A2
2.775e-02	-3.58	PAS_3	pfam domains	PF08447	10	1	17795	50	HIF1A
2.776e-02	-3.58	MSH6 (mutS homolog 6)	protein interactions	2956	255	3	19454	50	P2RY6,HIF1A,RIN3
2.777e-02	-3.58	GoLoco	smart domains	SM00390	7	1	9717	39	RGS14
2.777e-02	-3.58	IRF-3	smart domains	SM01243	7	1	9717	39	IRF5
2.777e-02	-3.58	RBD	smart domains	SM00455	7	1	9717	39	RGS14
2.780e-02	-3.58	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	4	18204	49	PIK3CB,HIF1A,APOE,SLC4A2
2.780e-02	-3.58	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	49	RGS14,PIK3CB,SYK,CSF1R
2.781e-02	-3.58	MYO9B (myosin IXB)	protein interactions	4650	101	2	19454	50	SKAP1,HIF1A
2.781e-02	-3.58	FBXO28 (F-box protein 28)	protein interactions	23219	101	2	19454	50	HIF1A,GIT2
2.781e-02	-3.58	BMAL1 (basic helix-loop-helix ARNT like 1)	protein interactions	406	101	2	19454	50	GIT2,HIF1A
2.781e-02	-3.58	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	50	RHBDF2,PTPN6
2.788e-02	-3.58	negative regulation of apoptotic signaling pathway	biological process	GO:2001234	244	3	18204	49	HIF1A,CD74,PIK3CB
2.792e-02	-3.58	ADGRG2 (adhesion G protein-coupled receptor G2)	protein interactions	10149	11	1	19454	50	GMIP
2.792e-02	-3.58	LAT2 (linker for activation of T cells family member 2)	protein interactions	7462	11	1	19454	50	PLCG2
2.792e-02	-3.58	RPS10-NUDT3 (RPS10-NUDT3 readthrough)	protein interactions	100529239	11	1	19454	50	RIN3
2.792e-02	-3.58	KLHL32 (kelch like family member 32)	protein interactions	114792	11	1	19454	50	PARVG
2.792e-02	-3.58	CYP1A2 (cytochrome P450 family 1 subfamily A member 2)	protein interactions	1544	11	1	19454	50	HIF1A
2.792e-02	-3.58	SPATA12 (spermatogenesis associated 12)	protein interactions	353324	11	1	19454	50	RIN3
2.792e-02	-3.58	LAX1 (lymphocyte transmembrane adaptor 1)	protein interactions	54900	11	1	19454	50	SYK
2.792e-02	-3.58	FERRY3 (FERRY endosomal RAB5 effector complex subunit 3)	protein interactions	57102	11	1	19454	50	IL6R
2.792e-02	-3.58	GHSR (growth hormone secretagogue receptor)	protein interactions	2693	11	1	19454	50	P2RY6
2.810e-02	-3.57	leukocyte homeostasis	biological process	GO:0001776	97	2	18204	49	DOCK10,HIF1A
2.813e-02	-3.57	thyroid-carcinoma-anaplastic_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-anaplastic_carcinoma	856	6	16828	46	DOCK8,PIK3CB,SKAP1,DOCK2,HIF1A,DOCK1
2.813e-02	-3.57	anaplastic_carcinoma	COSMIC cancer mutations	anaplastic_carcinoma	856	6	16828	46	PIK3CB,SKAP1,DOCK2,DOCK8,HIF1A,DOCK1
2.814e-02	-3.57	Central carbon metabolism in cancer	KEGG pathways	hsa05230	65	2	7161	29	PIK3CB,HIF1A
2.814e-02	-3.57	Central carbon metabolism in cancer	KEGG pathways	ko05230	65	2	7161	29	HIF1A,PIK3CB
2.823e-02	-3.57	Apoptosis-related network due to altered Notch3 in ovarian cancer	WikiPathways	WP2864	54	2	5310	26	VAV3,APOE
2.832e-02	-3.56	human chr14q23.2	chromosome location	human chr14q23.2	15	1	26134	50	HIF1A
2.832e-02	-3.56	human chr12q21.2	chromosome location	human chr12q21.2	15	1	26134	50	GLIPR1
2.832e-02	-3.56	human chr9p24.3	chromosome location	human chr9p24.3	15	1	26134	50	DOCK8
2.847e-02	-3.56	regulation of synapse organization	biological process	GO:0050807	246	3	18204	49	APOE,SEMA4A,ARHGAP33
2.847e-02	-3.56	response to toxic substance	biological process	GO:0009636	246	3	18204	49	ARHGAP33,IPCEF1,APOE
2.853e-02	-3.56	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	633	5	16828	46	P2RY2,AKAP13,PREX1,RHBDF2,DOCK10
2.877e-02	-3.55	cellular response to biotic stimulus	biological process	GO:0071216	247	3	18204	49	SYK,PLCG2,SBNO2
2.880e-02	-3.55	nitric-oxide synthase binding	molecular function	GO:0050998	11	1	18094	48	CD74
2.880e-02	-3.55	cardiolipin binding	molecular function	GO:1901612	11	1	18094	48	GSDME
2.880e-02	-3.55	GTPase activating protein binding	molecular function	GO:0032794	11	1	18094	48	RGS14
2.880e-02	-3.55	T cell receptor binding	molecular function	GO:0042608	11	1	18094	48	DOCK2
2.884e-02	-3.55	PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1)	protein interactions	54704	103	2	19454	50	HIF1A,PRKCD
2.884e-02	-3.55	MANSC1 (MANSC domain containing 1)	protein interactions	54682	103	2	19454	50	APOE,PIK3CB
2.884e-02	-3.55	GADD45A (growth arrest and DNA damage inducible alpha)	protein interactions	1647	103	2	19454	50	PARVG,MICAL1
2.885e-02	-3.55	regulation of protein transport	biological process	GO:0051223	433	4	18204	49	PRKCD,RHBDF2,APOE,HIF1A
2.885e-02	-3.55	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	49	APOE,HIF1A,PIK3CB,TBXAS1
2.912e-02	-3.54	G alpha (q) signalling events	REACTOME pathways	R-HSA-416476	192	3	10285	36	P2RY6,P2RY2,PRKCD
2.917e-02	-3.53	RECEPTOR_TYR_KIN_III	prosite domains	PS00240	8	1	12186	45	CSF1R
2.917e-02	-3.53	TH1	prosite domains	PS51757	8	1	12186	45	MYO1F
2.917e-02	-3.53	C2_PI3K	prosite domains	PS51547	8	1	12186	45	PIK3CB
2.917e-02	-3.53	PH_BEACH	prosite domains	PS51783	8	1	12186	45	WDFY4
2.917e-02	-3.53	negative regulation of leukocyte proliferation	biological process	GO:0070664	99	2	18204	49	SLC4A2,PTPN6
2.917e-02	-3.53	regulation of signaling receptor activity	biological process	GO:0010469	99	2	18204	49	HIF1A,PRKCD
2.917e-02	-3.53	activation of GTPase activity	biological process	GO:0090630	99	2	18204	49	TBC1D8,GMIP
2.917e-02	-3.53	response to stress	biological process	GO:0006950	3388	15	18204	49	VAV3,WAS,SYK,PTPN6,IRF5,IPCEF1,PLCG2,HIF1A,APOE,RGS14,PIK3CB,CSF1R,IL6R,CD74,PRKCD
2.922e-02	-3.53	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	49	APOE
2.922e-02	-3.53	regulation of dendritic cell antigen processing and presentation	biological process	GO:0002604	11	1	18204	49	CD74
2.922e-02	-3.53	positive regulation of chemokine (C-X-C motif) ligand 2 production	biological process	GO:2000343	11	1	18204	49	CD74
2.922e-02	-3.53	collagen-activated tyrosine kinase receptor signaling pathway	biological process	GO:0038063	11	1	18204	49	SYK
2.922e-02	-3.53	pinocytosis	biological process	GO:0006907	11	1	18204	49	DOCK2
2.922e-02	-3.53	positive regulation of integrin activation	biological process	GO:0033625	11	1	18204	49	SKAP1
2.922e-02	-3.53	regulation of fear response	biological process	GO:1903365	11	1	18204	49	APOE
2.922e-02	-3.53	regulation of cell-cell adhesion mediated by integrin	biological process	GO:0033632	11	1	18204	49	SKAP1
2.922e-02	-3.53	negative regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002924	11	1	18204	49	PTPN6
2.922e-02	-3.53	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	49	PRKCD
2.922e-02	-3.53	CD8-positive, alpha-beta T cell activation	biological process	GO:0036037	11	1	18204	49	WDFY4
2.922e-02	-3.53	regulation of gamma-delta T cell activation	biological process	GO:0046643	11	1	18204	49	SYK
2.922e-02	-3.53	negative regulation of mesenchymal cell apoptotic process	biological process	GO:2001054	11	1	18204	49	HIF1A
2.922e-02	-3.53	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	49	APOE
2.931e-02	-3.53	SM22_calponin	interpro domains	IPR003096	11	1	18521	50	VAV3
2.931e-02	-3.53	WH1/EVH1_dom	interpro domains	IPR000697	11	1	18521	50	WAS
2.936e-02	-3.53	CDH5 (cadherin 5)	protein interactions	1003	104	2	19454	50	PIK3CB,P2RY2
2.937e-02	-3.53	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	24	16828	46	AKAP13,RIN3,PARVG,SYK,P2RY6,DOCK10,ARHGAP33,SKAP1,WDFY4,ARHGAP27,PREX1,ADCY7,MYO1F,PIK3CB,DOCK2,PIK3R5,DOCK1,RGS14,PRKCD,TBXAS1,VAV3,MICAL1,PLCG2,ELMO1
2.947e-02	-3.52	Phosphatidylinositol 3-kinase, accessory domain (PIK)	gene3d domains	1.25.40.70	9	1	14470	48	PIK3CB
2.947e-02	-3.52	BEACH domain	gene3d domains	1.10.1540.10	9	1	14470	48	WDFY4
2.947e-02	-3.52	Nucleotidyltransferases domain 2	gene3d domains	1.20.120.330	9	1	14470	48	GIT2
2.951e-02	-3.52	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	46	CSF1R,SYK,PRKCD,NEK6
2.951e-02	-3.52	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	46	SYK,PRKCD,NEK6,CSF1R
2.956e-02	-3.52	positive regulation of cellular component organization	biological process	GO:0051130	1122	7	18204	49	DOCK2,SEMA4A,SYK,PLCG2,HIF1A,APOE,SKAP1
2.972e-02	-3.52	regulation of T cell mediated immunity	biological process	GO:0002709	100	2	18204	49	DENND1B,WAS
2.972e-02	-3.52	positive regulation of smooth muscle cell proliferation	biological process	GO:0048661	100	2	18204	49	P2RY6,IL6R
2.988e-02	-3.51	TMEM52B (transmembrane protein 52B)	protein interactions	120939	105	2	19454	50	PIK3CB,RHBDF2
3.027e-02	-3.50	B cell mediated immunity	biological process	GO:0019724	101	2	18204	49	PRKCD,CD74
3.027e-02	-3.50	regulation of synapse structure or activity	biological process	GO:0050803	252	3	18204	49	APOE,SEMA4A,ARHGAP33
3.033e-02	-3.50	RCN2 (reticulocalbin 2)	protein interactions	5955	264	3	19454	50	APOE,P2RY6,RIN3
3.033e-02	-3.50	PCBP2 (poly(rC) binding protein 2)	protein interactions	5094	264	3	19454	50	RIN3,P2RY6,HIF1A
3.035e-02	-3.49	positive regulation of developmental process	biological process	GO:0051094	1385	8	18204	49	IL6R,HIF1A,APOE,RGS14,SLC4A2,SYK,SEMA4A,CD74
3.040e-02	-3.49	PTN (pleiotrophin)	protein interactions	5764	106	2	19454	50	NEK6,GSDME
3.042e-02	-3.49	MATCAP2 (microtubule associated tyrosine carboxypeptidase 2)	protein interactions	23366	12	1	19454	50	MICAL1
3.042e-02	-3.49	TENM4 (teneurin transmembrane protein 4)	protein interactions	26011	12	1	19454	50	DOCK2
3.042e-02	-3.49	ROPN1L (rhophilin associated tail protein 1 like)	protein interactions	83853	12	1	19454	50	CD74
3.042e-02	-3.49	RPL17-C18orf32 (RPL17-C18orf32 readthrough)	protein interactions	100526842	12	1	19454	50	RIN3
3.042e-02	-3.49	SIRPB1 (signal regulatory protein beta 1)	protein interactions	10326	12	1	19454	50	SYK
3.042e-02	-3.49	SSTR2 (somatostatin receptor 2)	protein interactions	6752	12	1	19454	50	PTPN6
3.042e-02	-3.49	RTL8B (retrotransposon Gag like 8B)	protein interactions	441518	12	1	19454	50	RIN3
3.042e-02	-3.49	FBXO8 (F-box protein 8)	protein interactions	26269	12	1	19454	50	HIF1A
3.042e-02	-3.49	NCF4 (neutrophil cytosolic factor 4)	protein interactions	4689	12	1	19454	50	PRKCD
3.042e-02	-3.49	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	50	APOE
3.042e-02	-3.49	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	50	PTPN6
3.042e-02	-3.49	ADGRB3 (adhesion G protein-coupled receptor B3)	protein interactions	577	12	1	19454	50	ELMO1
3.049e-02	-3.49	WH1	pfam domains	PF00568	11	1	17795	50	WAS
3.059e-02	-3.49	INTFRNREGFCT	prints domains	PR00267	9	1	5227	18	IRF5
3.062e-02	-3.49	OSBPL8 (oxysterol binding protein like 8)	protein interactions	114882	265	3	19454	50	CD74,SYK,P2RY6
3.073e-02	-3.48	C20 prostanoid biosynthesis	BIOCYC pathways	HUMAN_PWY66-374	7	1	902	4	TBXAS1
3.073e-02	-3.48	C20 prostanoid biosynthesis	BIOCYC pathways	META_PWY66-374	7	1	902	4	TBXAS1
3.078e-02	-3.48	small_intestine	COSMIC cancer mutations	small_intestine	250	3	16828	46	CSF1R,ARHGAP33,PREX1
3.082e-02	-3.48	regulation of interleukin-8 production	biological process	GO:0032677	102	2	18204	49	SYK,CD74
3.101e-02	-3.47	PI Metabolism	REACTOME pathways	R-HSA-1483255	79	2	10285	36	PIK3CB,PIK3R5
3.108e-02	-3.47	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	5	12186	45	CSF1R,SYK,NEK6,PRKCD,NRK
3.108e-02	-3.47	MAPK1 (ERK2) activation	REACTOME pathways	R-HSA-112411	9	1	10285	36	IL6R
3.109e-02	-3.47	monooxygenase activity	molecular function	GO:0004497	104	2	18094	48	MICAL1,TBXAS1
3.126e-02	-3.47	transferase activity, transferring phosphorus-containing groups	molecular function	GO:0016772	903	6	18094	48	SYK,NRK,NEK6,PIK3CB,PRKCD,CSF1R
3.138e-02	-3.46	unsaturated fatty acid metabolic process	biological process	GO:0033559	103	2	18204	49	TBXAS1,CD74
3.138e-02	-3.46	regulation of biomineral tissue development	biological process	GO:0070167	103	2	18204	49	HIF1A,SLC4A2
3.138e-02	-3.46	bicarbonate:monoatomic anion antiporter activity	molecular function	GO:0140829	12	1	18094	48	SLC4A2
3.138e-02	-3.46	chloride:bicarbonate antiporter activity	molecular function	GO:0140900	12	1	18094	48	SLC4A2
3.138e-02	-3.46	non-membrane spanning protein tyrosine phosphatase activity	molecular function	GO:0004726	12	1	18094	48	PTPN6
3.138e-02	-3.46	MAP-kinase scaffold activity	molecular function	GO:0005078	12	1	18094	48	AKAP13
3.143e-02	-3.46	RIGI (RNA sensor RIG-I)	protein interactions	23586	1739	9	19454	50	PLCG2,PTPN6,SLC4A2,RIN3,SBNO2,MYO1F,RHBDF2,GMIP,GIT2
3.145e-02	-3.46	negative regulation of catalytic activity	biological process	GO:0043086	445	4	18204	49	RGS14,APOE,GMIP,PRKCD
3.147e-02	-3.46	SLC39A14 (solute carrier family 39 member 14)	protein interactions	23516	108	2	19454	50	P2RY2,P2RY6
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	EHBP1L1,RIN3
3.149e-02	-3.46	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	50	AKAP13,GIT2,DOCK8,DOCK1
3.167e-02	-3.45	VPS9	smart domains	SM00167	8	1	9717	39	RIN3
3.167e-02	-3.45	PI3K_C2	smart domains	SM00142	8	1	9717	39	PIK3CB
3.181e-02	-3.45	PGRMC2 (progesterone receptor membrane component 2)	protein interactions	10424	269	3	19454	50	CD74,RHBDF2,P2RY6
3.184e-02	-3.45	actin filament depolymerization	biological process	GO:0030042	12	1	18204	49	MICAL1
3.184e-02	-3.45	regulation of prostaglandin biosynthetic process	biological process	GO:0031392	12	1	18204	49	CD74
3.184e-02	-3.45	response to macrophage colony-stimulating factor	biological process	GO:0036005	12	1	18204	49	CSF1R
3.184e-02	-3.45	positive regulation of dendritic cell cytokine production	biological process	GO:0002732	12	1	18204	49	PLCG2
3.184e-02	-3.45	mesenchymal cell apoptotic process	biological process	GO:0097152	12	1	18204	49	HIF1A
3.184e-02	-3.45	serotonin transport	biological process	GO:0006837	12	1	18204	49	SYK
3.184e-02	-3.45	insulin secretion involved in cellular response to glucose stimulus	biological process	GO:0035773	12	1	18204	49	HIF1A
3.184e-02	-3.45	nuclear membrane disassembly	biological process	GO:0051081	12	1	18204	49	NEK6
3.184e-02	-3.45	bone trabecula morphogenesis	biological process	GO:0061430	12	1	18204	49	SBNO2
3.184e-02	-3.45	regulation of chemokine-mediated signaling pathway	biological process	GO:0070099	12	1	18204	49	HIF1A
3.184e-02	-3.45	regulation of glial cell apoptotic process	biological process	GO:0034350	12	1	18204	49	PRKCD
3.184e-02	-3.45	regulation of inflammatory response to wounding	biological process	GO:0106014	12	1	18204	49	PTPN6
3.184e-02	-3.45	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	49	APOE
3.184e-02	-3.45	inositol phosphate biosynthetic process	biological process	GO:0032958	12	1	18204	49	PLCG2
3.184e-02	-3.45	regulation of glomerular mesangial cell proliferation	biological process	GO:0072124	12	1	18204	49	IL6R
3.194e-02	-3.44	protein polymerization	biological process	GO:0051258	104	2	18204	49	WAS,PREX1
3.194e-02	-3.44	regulation of actomyosin structure organization	biological process	GO:0110020	104	2	18204	49	AKAP13,WAS
3.204e-02	-3.44	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	5	16828	46	ELMO1,WDFY4,SKAP1,PIK3CB,DOCK10
3.204e-02	-3.44	human chr1q31.3	chromosome location	human chr1q31.3	17	1	26134	50	DENND1B
3.204e-02	-3.44	human chr16q23.3	chromosome location	human chr16q23.3	17	1	26134	50	PLCG2
3.222e-02	-3.44	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	5	16828	46	DOCK10,WDFY4,SKAP1,PIK3CB,ELMO1
3.232e-02	-3.43	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	12	1	16828	46	CSF1R
3.235e-02	-3.43	regulation of innate immune response	biological process	GO:0045088	449	4	18204	49	APOE,SYK,PTPN6,PLCG2
3.243e-02	-3.43	Axon guidance	KEGG pathways	ko04360	174	3	7161	29	PIK3CB,SEMA4A,PLCG2
3.243e-02	-3.43	Axon guidance	KEGG pathways	hsa04360	174	3	7161	29	PIK3CB,SEMA4A,PLCG2
3.251e-02	-3.43	response to type II interferon	biological process	GO:0034341	105	2	18204	49	WAS,CD74
3.251e-02	-3.43	antigen processing and presentation	biological process	GO:0019882	105	2	18204	49	CD74,WDFY4
3.251e-02	-3.43	positive regulation of myeloid cell differentiation	biological process	GO:0045639	105	2	18204	49	HIF1A,CD74
3.251e-02	-3.43	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	49	ARHGAP33,APOE
3.251e-02	-3.43	biomineral tissue development	biological process	GO:0031214	105	2	18204	49	HIF1A,SBNO2
3.251e-02	-3.43	cellular response to alcohol	biological process	GO:0097306	105	2	18204	49	P2RY6,ADCY7
3.254e-02	-3.43	SLC27A2 (solute carrier family 27 member 2)	protein interactions	11001	110	2	19454	50	GSDME,P2RY6
3.269e-02	-3.42	VPS9 domain	gene3d domains	1.20.1050.80	10	1	14470	48	RIN3
3.269e-02	-3.42	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	48	SLC4A2
3.269e-02	-3.42	Rhomboid-like	gene3d domains	1.20.1540.10	10	1	14470	48	RHBDF2
3.269e-02	-3.42	CRIB domain	gene3d domains	3.90.810.10	10	1	14470	48	WAS
3.273e-02	-3.42	Interferon Signaling	REACTOME pathways	R-HSA-913531	201	3	10285	36	PTPN6,IRF5,PRKCD
3.276e-02	-3.42	IRF_1	prosite domains	PS00601	9	1	12186	45	IRF5
3.276e-02	-3.42	CRISP_2	prosite domains	PS01010	9	1	12186	45	GLIPR1
3.276e-02	-3.42	IRF_2	prosite domains	PS51507	9	1	12186	45	IRF5
3.276e-02	-3.42	BEACH	prosite domains	PS50197	9	1	12186	45	WDFY4
3.291e-02	-3.41	GABPB2 (GA binding protein transcription factor subunit beta 2)	protein interactions	126626	13	1	19454	50	PLCG2
3.291e-02	-3.41	NFAM1 (NFAT activating protein with ITAM motif 1)	protein interactions	150372	13	1	19454	50	SYK
3.291e-02	-3.41	IL6 (interleukin 6)	protein interactions	3569	13	1	19454	50	IL6R
3.291e-02	-3.41	EEIG1 (estrogen-induced osteoclastogenesis regulator 1)	protein interactions	399665	13	1	19454	50	SKAP1
3.291e-02	-3.41	RTL10 (retrotransposon Gag like 10)	protein interactions	79680	13	1	19454	50	PLCG2
3.291e-02	-3.41	SEMA4A (semaphorin 4A)	protein interactions	64218	13	1	19454	50	SEMA4A
3.291e-02	-3.41	KCNQ4 (potassium voltage-gated channel subfamily Q member 4)	protein interactions	9132	13	1	19454	50	CSF1R
3.291e-02	-3.41	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	50	APOE
3.291e-02	-3.41	REP15 (RAB15 effector protein)	protein interactions	387849	13	1	19454	50	SLC4A2
3.312e-02	-3.41	Inositol phosphate metabolism	KEGG pathways	hsa00562	71	2	7161	29	PLCG2,PIK3CB
3.312e-02	-3.41	Bile secretion	KEGG pathways	ko04976	71	2	7161	29	SLC4A2,ADCY7
3.312e-02	-3.41	Inositol phosphate metabolism	KEGG pathways	ko00562	71	2	7161	29	PIK3CB,PLCG2
3.312e-02	-3.41	Bile secretion	KEGG pathways	hsa04976	71	2	7161	29	SLC4A2,ADCY7
3.321e-02	-3.40	dDENN	pfam domains	PF03455	12	1	17795	50	DENND1B
3.341e-02	-3.40	response to alcohol	biological process	GO:0097305	262	3	18204	49	TBXAS1,P2RY6,ADCY7
3.350e-02	-3.40	early phagosome	cellular component	GO:0032009	13	1	19108	50	SYK
3.350e-02	-3.40	chylomicron	cellular component	GO:0042627	13	1	19108	50	APOE
3.363e-02	-3.39	UBE2V1 (ubiquitin conjugating enzyme E2 V1)	protein interactions	7335	112	2	19454	50	P2RY6,RHBDF2
3.363e-02	-3.39	ENAH (ENAH actin regulator)	protein interactions	55740	112	2	19454	50	FYB1,WAS
3.373e-02	-3.39	regulation of cellular catabolic process	biological process	GO:0031329	455	4	18204	49	APOE,HIF1A,PIK3CB,PRKCD
3.394e-02	-3.38	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	18	SLC4A2
3.394e-02	-3.38	HMOX2 (heme oxygenase 2)	protein interactions	3163	276	3	19454	50	CD74,P2RY6,APOE
3.398e-02	-3.38	Adherens junction	KEGG pathways	hsa04520	72	2	7161	29	WAS,PTPN6
3.398e-02	-3.38	Adherens junction	KEGG pathways	ko04520	72	2	7161	29	WAS,PTPN6
3.418e-02	-3.38	ARHGEF7 (Rho guanine nucleotide exchange factor 7)	protein interactions	8874	113	2	19454	50	WAS,GIT2
3.432e-02	-3.37	Regulation of CDC42 activity	Pathway Interaction DB	cdc42_reg_pathway	30	2	2226	22	VAV3,DOCK10
3.439e-02	-3.37	regulation of protein secretion	biological process	GO:0050708	265	3	18204	49	HIF1A,RHBDF2,APOE
3.443e-02	-3.37	positive regulation of cell development	biological process	GO:0010720	458	4	18204	49	CD74,RGS14,HIF1A,SYK
3.444e-02	-3.37	positive regulation of inositol phosphate biosynthetic process	biological process	GO:0060732	13	1	18204	49	P2RY6
3.444e-02	-3.37	positive regulation of membrane invagination	biological process	GO:1905155	13	1	18204	49	PLCG2
3.444e-02	-3.37	regulation of sphingolipid biosynthetic process	biological process	GO:0090153	13	1	18204	49	PRKCD
3.444e-02	-3.37	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	biological process	GO:1903377	13	1	18204	49	HIF1A
3.444e-02	-3.37	modulation of process of another organism	biological process	GO:0035821	13	1	18204	49	SYK
3.444e-02	-3.37	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	1	18204	49	APOE
3.444e-02	-3.37	regulation of T-helper 2 cell cytokine production	biological process	GO:2000551	13	1	18204	49	DENND1B
3.444e-02	-3.37	regulation of thymocyte apoptotic process	biological process	GO:0070243	13	1	18204	49	HIF1A
3.444e-02	-3.37	phospholipid efflux	biological process	GO:0033700	13	1	18204	49	APOE
3.444e-02	-3.37	membrane disassembly	biological process	GO:0030397	13	1	18204	49	NEK6
3.444e-02	-3.37	positive regulation of phagocytosis, engulfment	biological process	GO:0060100	13	1	18204	49	PLCG2
3.444e-02	-3.37	regulation of ceramide biosynthetic process	biological process	GO:2000303	13	1	18204	49	PRKCD
3.444e-02	-3.37	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	49	IL6R
3.444e-02	-3.37	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	49	APOE
3.444e-02	-3.37	positive regulation of mitophagy	biological process	GO:1901526	13	1	18204	49	HIF1A
3.444e-02	-3.37	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	49	PRKCD
3.444e-02	-3.37	regulation of tooth mineralization	biological process	GO:0070170	13	1	18204	49	SLC4A2
3.444e-02	-3.37	response to peptidoglycan	biological process	GO:0032494	13	1	18204	49	IRF5
3.444e-02	-3.37	positive regulation of nitric-oxide synthase activity	biological process	GO:0051000	13	1	18204	49	HIF1A
3.447e-02	-3.37	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	36	SLC4A2
3.447e-02	-3.37	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	36	ADCY7
3.447e-02	-3.37	MAPK3 (ERK1) activation	REACTOME pathways	R-HSA-110056	10	1	10285	36	IL6R
3.466e-02	-3.36	small molecule biosynthetic process	biological process	GO:0044283	459	4	18204	49	CD74,SYK,PLCG2,TBXAS1
3.481e-02	-3.36	postsynapse organization	biological process	GO:0099173	109	2	18204	49	DOCK10,APOE
3.481e-02	-3.36	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	2	18204	49	SYK,PLCG2
3.488e-02	-3.36	IRS4 (insulin receptor substrate 4)	protein interactions	8471	279	3	19454	50	RIN3,PIK3CB,PTPN6
3.490e-02	-3.36	negative regulation of transport	biological process	GO:0051051	460	4	18204	49	RIN3,CD74,APOE,RHBDF2
3.506e-02	-3.35	cellular lipid metabolic process	biological process	GO:0044255	914	6	18204	49	TBXAS1,PLCG2,PIK3CB,CD74,PIK3R5,APOE
3.506e-02	-3.35	chemical homeostasis	biological process	GO:0048878	914	6	18204	49	SLC4A2,P2RY2,TBXAS1,APOE,HIF1A,PIK3CB
3.537e-02	-3.34	protein localization to membrane	biological process	GO:0072657	462	4	18204	49	FYB1,SKAP1,APOE,RHBDF2
3.539e-02	-3.34	negative regulation of leukocyte differentiation	biological process	GO:1902106	110	2	18204	49	SLC4A2,CD74
3.539e-02	-3.34	phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	GO:0007200	110	2	18204	49	P2RY6,P2RY2
3.540e-02	-3.34	CSF3 (colony stimulating factor 3)	protein interactions	1440	14	1	19454	50	PARVG
3.540e-02	-3.34	RHBDF1 (rhomboid 5 homolog 1)	protein interactions	64285	14	1	19454	50	HIF1A
3.540e-02	-3.34	C9 (complement C9)	protein interactions	735	14	1	19454	50	APOE
3.540e-02	-3.34	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	50	APOE
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	PRKCD
3.540e-02	-3.34	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	50	P2RY6
3.540e-02	-3.34	AGTR2 (angiotensin II receptor type 2)	protein interactions	186	14	1	19454	50	PIK3CB
3.540e-02	-3.34	TAS2R7 (taste 2 receptor member 7)	protein interactions	50837	14	1	19454	50	MICAL1
3.540e-02	-3.34	Iqgap3 (IQ motif containing GTPase activating protein 3)	protein interactions	404710	14	1	19454	50	SLC4A2
3.540e-02	-3.34	Fez2 (fasciculation and elongation protein zeta 2)	protein interactions	225020	14	1	19454	50	DENND1B
3.547e-02	-3.34	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	2	10285	36	ADCY7,PRKCD
3.549e-02	-3.34	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	46	PRKCD,SYK,NEK6,CSF1R
3.556e-02	-3.34	Beach	smart domains	SM01026	9	1	9717	39	WDFY4
3.556e-02	-3.34	PI3Ka	smart domains	SM00145	9	1	9717	39	PIK3CB
3.556e-02	-3.34	IRF	smart domains	SM00348	9	1	9717	39	IRF5
3.574e-02	-3.33	human chr15q25.3	chromosome location	human chr15q25.3	19	1	26134	50	AKAP13
3.587e-02	-3.33	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	12	16828	46	AKAP13,DOCK2,PIK3CB,CSF1R,DOCK1,SLC4A2,DOCK10,WDFY4,SKAP1,VAV3,PREX1,ELMO1
3.592e-02	-3.33	PRKACA (protein kinase cAMP-activated catalytic subunit alpha)	protein interactions	5566	486	4	19454	50	DOCK1,AKAP13,HIF1A,RGS14
3.598e-02	-3.32	positive regulation of lipid localization	biological process	GO:1905954	111	2	18204	49	APOE,PRKCD
3.598e-02	-3.32	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	46	NEK6,SYK,PRKCD,CSF1R
3.615e-02	-3.32	PRDX3 (peroxiredoxin 3)	protein interactions	10935	283	3	19454	50	DOCK8,APOE,NEK6
3.619e-02	-3.32	signaling adaptor activity	molecular function	GO:0035591	113	2	18094	48	AKAP13,RGS14
3.630e-02	-3.32	positive regulation of metabolic process	biological process	GO:0009893	3796	16	18204	49	SKAP1,SBNO2,WAS,PIK3R5,P2RY6,PLCG2,IRF5,DENND1B,SYK,IL6R,CSF1R,APOE,HIF1A,PIK3CB,CD74,PRKCD
3.632e-02	-3.32	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	26	ADCY7,RGS14,PRKCD
3.633e-02	-3.32	PIK_HELICAL	prosite domains	PS51545	10	1	12186	45	PIK3CB
3.633e-02	-3.32	VPS9	prosite domains	PS51205	10	1	12186	45	RIN3
3.635e-02	-3.31	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	6	19454	50	RIN3,DENND1B,PRKCD,CD74,AKAP13,P2RY6
3.638e-02	-3.31	carboxylic acid biosynthetic process	biological process	GO:0046394	271	3	18204	49	SYK,CD74,TBXAS1
3.642e-02	-3.31	PTGER3 (prostaglandin E receptor 3)	protein interactions	5733	117	2	19454	50	PIK3CB,RHBDF2
3.642e-02	-3.31	PACSIN3 (protein kinase C and casein kinase substrate in neurons 3)	protein interactions	29763	117	2	19454	50	RIN3,WAS
3.652e-02	-3.31	oxygen carrier activity	molecular function	GO:0005344	14	1	18094	48	IPCEF1
3.652e-02	-3.31	Toll-like receptor binding	molecular function	GO:0035325	14	1	18094	48	SYK
3.657e-02	-3.31	mononuclear cell migration	biological process	GO:0071674	112	2	18204	49	DOCK8,IL6R
3.662e-02	-3.31	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	29	SLC4A2,ADCY7
3.662e-02	-3.31	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	29	SLC4A2,ADCY7
3.664e-02	-3.31	positive regulation of macromolecule metabolic process	biological process	GO:0010604	3485	15	18204	49	SYK,PLCG2,IRF5,DENND1B,PIK3R5,SBNO2,SKAP1,WAS,CD74,PRKCD,HIF1A,APOE,PIK3CB,CSF1R,IL6R
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	GSDME,DENND1B,ARHGAP33
3.677e-02	-3.30	transcription coregulator binding	molecular function	GO:0001221	114	2	18094	48	HIF1A,NEK6
3.680e-02	-3.30	IPO7 (importin 7)	protein interactions	10527	285	3	19454	50	RHBDF2,P2RY6,RIN3
3.699e-02	-3.30	NCKIPSD (NCK interacting protein with SH3 domain)	protein interactions	51517	118	2	19454	50	WAS,GIT2
3.703e-02	-3.30	angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	angioimmunoblastic_T_cell_lymphoma	269	3	16828	46	SYK,CSF1R,PLCG2
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	P2RY6
3.704e-02	-3.30	inflammatory response to wounding	biological process	GO:0090594	14	1	18204	49	HIF1A
3.704e-02	-3.30	positive regulation of viral entry into host cell	biological process	GO:0046598	14	1	18204	49	CD74
3.704e-02	-3.30	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	49	APOE
3.704e-02	-3.30	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	49	APOE
3.704e-02	-3.30	regulation of mesenchymal cell apoptotic process	biological process	GO:2001053	14	1	18204	49	HIF1A
3.704e-02	-3.30	alpha-beta T cell proliferation	biological process	GO:0046633	14	1	18204	49	DOCK2
3.704e-02	-3.30	T-helper cell lineage commitment	biological process	GO:0002295	14	1	18204	49	IL6R
3.704e-02	-3.30	positive regulation of heterotypic cell-cell adhesion	biological process	GO:0034116	14	1	18204	49	SKAP1
3.704e-02	-3.30	interleukin-6-mediated signaling pathway	biological process	GO:0070102	14	1	18204	49	IL6R
3.704e-02	-3.30	cellular response to ethanol	biological process	GO:0071361	14	1	18204	49	ADCY7
3.704e-02	-3.30	regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001279	14	1	18204	49	CD74
3.704e-02	-3.30	positive regulation by symbiont of entry into host	biological process	GO:0075294	14	1	18204	49	CD74
3.704e-02	-3.30	T-helper 1 cell differentiation	biological process	GO:0045063	14	1	18204	49	SEMA4A
3.704e-02	-3.30	positive regulation of phospholipid metabolic process	biological process	GO:1903727	14	1	18204	49	PRKCD
3.704e-02	-3.30	cellular response to lithium ion	biological process	GO:0071285	14	1	18204	49	ADCY7
3.706e-02	-3.30	vascular process in circulatory system	biological process	GO:0003018	273	3	18204	49	P2RY2,TBXAS1,APOE
3.712e-02	-3.29	PRDX2 (peroxiredoxin 2)	protein interactions	7001	286	3	19454	50	RIN3,AKAP13,APOE
3.715e-02	-3.29	Rhomboid-like_sf	interpro domains	IPR035952	14	1	18521	50	RHBDF2
3.717e-02	-3.29	regulation of regulated secretory pathway	biological process	GO:1903305	113	2	18204	49	SYK,MICAL1
3.717e-02	-3.29	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	2	18204	49	SYK,PLCG2
3.727e-02	-3.29	SM22CALPONIN	prints domains	PR00888	11	1	5227	18	VAV3
3.740e-02	-3.29	organic acid biosynthetic process	biological process	GO:0016053	274	3	18204	49	SYK,CD74,TBXAS1
3.745e-02	-3.28	PSMD13 (proteasome 26S subunit, non-ATPase 13)	protein interactions	5719	287	3	19454	50	P2RY6,PTPN6,PREX1
3.747e-02	-3.28	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	46	CSF1R,NEK6,PRKCD,SYK
3.754e-02	-3.28	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	8	16828	46	P2RY6,DOCK1,TBC1D8,DOCK2,GMIP,EHBP1L1,DOCK10,AKAP13
3.754e-02	-3.28	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	8	16828	46	DOCK1,P2RY6,EHBP1L1,DOCK10,AKAP13,DOCK2,GMIP,TBC1D8
3.756e-02	-3.28	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	50	APOE,CD74
3.768e-02	-3.28	ATP binding	molecular function	GO:0005524	1467	8	18094	48	NRK,CSF1R,NEK6,PRKCD,PIK3CB,MYO1F,SYK,ADCY7
3.772e-02	-3.28	intracellular transport	biological process	GO:0046907	1182	7	18204	49	DENND1B,SYK,CD74,WAS,RGS14,APOE,HIF1A
3.777e-02	-3.28	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	3	19454	50	FYB1,HIF1A,WAS
3.779e-02	-3.28	VDAC1 (voltage dependent anion channel 1)	protein interactions	7416	494	4	19454	50	P2RY6,APOE,CD74,RIN3
3.785e-02	-3.27	Interleukin-6 signaling	REACTOME pathways	R-HSA-1059683	11	1	10285	36	IL6R
3.788e-02	-3.27	Ccn1 (cellular communication network factor 1)	protein interactions	16007	15	1	19454	50	SLC4A2
3.788e-02	-3.27	MEP1B (meprin A subunit beta)	protein interactions	4225	15	1	19454	50	PRKCD
3.788e-02	-3.27	NBEAL1 (neurobeachin like 1)	protein interactions	65065	15	1	19454	50	HIF1A
3.788e-02	-3.27	GCK (glucokinase)	protein interactions	2645	15	1	19454	50	GMIP
3.788e-02	-3.27	IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1)	protein interactions	134728	15	1	19454	50	RIN3
3.788e-02	-3.27	AANAT (aralkylamine N-acetyltransferase)	protein interactions	15	15	1	19454	50	P2RY6
3.788e-02	-3.27	IRF6 (interferon regulatory factor 6)	protein interactions	3664	15	1	19454	50	IRF5
3.788e-02	-3.27	EBI3 (Epstein-Barr virus induced 3)	protein interactions	10148	15	1	19454	50	PRKCD
3.788e-02	-3.27	ADRA2A (adrenoceptor alpha 2A)	protein interactions	150	15	1	19454	50	PRKCD
3.808e-02	-3.27	learning or memory	biological process	GO:0007611	276	3	18204	49	RGS14,APOE,HIF1A
3.814e-02	-3.27	ELP3 (elongator acetyltransferase complex subunit 3)	protein interactions	55140	120	2	19454	50	HIF1A,SKAP1
3.814e-02	-3.27	FNBP1 (formin binding protein 1)	protein interactions	23048	120	2	19454	50	RIN3,WAS
3.814e-02	-3.27	CD79B (CD79b molecule)	protein interactions	974	120	2	19454	50	PTPN6,SYK
3.825e-02	-3.26	acinar_carcinoma	COSMIC cancer mutations	acinar_carcinoma	1978	10	16828	46	DOCK10,RHBDF2,SKAP1,DOCK2,WDFY4,TBC1D8,MICAL1,PLCG2,RIN3,WAS
3.825e-02	-3.26	pancreas-carcinoma-acinar_carcinoma	COSMIC cancer mutations	pancreas-carcinoma-acinar_carcinoma	1978	10	16828	46	WAS,RIN3,PLCG2,MICAL1,TBC1D8,SKAP1,WDFY4,DOCK2,DOCK10,RHBDF2
3.837e-02	-3.26	fatty acid biosynthetic process	biological process	GO:0006633	115	2	18204	49	CD74,TBXAS1
3.855e-02	-3.26	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	50	APOE
3.857e-02	-3.26	RAB GEFs exchange GTP for GDP on RABs	REACTOME pathways	R-HSA-8876198	89	2	10285	36	RIN3,DENND1B
3.864e-02	-3.25	WH2	pfam domains	PF02205	14	1	17795	50	WAS
3.864e-02	-3.25	PBD	pfam domains	PF00786	14	1	17795	50	WAS
3.867e-02	-3.25	Osteopontin-mediated events	Pathway Interaction DB	avb3_opn_pathway	32	2	2226	22	VAV3,SYK
3.867e-02	-3.25	Alpha-synuclein signaling	Pathway Interaction DB	alphasynuclein_pathway	32	2	2226	22	SYK,PRKCD
3.872e-02	-3.25	EIF3J (eukaryotic translation initiation factor 3 subunit J)	protein interactions	8669	121	2	19454	50	CD74,P2RY6
3.872e-02	-3.25	POLR3B (RNA polymerase III subunit B)	protein interactions	55703	121	2	19454	50	SKAP1,CD74
3.872e-02	-3.25	MED15 (mediator complex subunit 15)	protein interactions	51586	121	2	19454	50	HIF1A,RIN3
3.898e-02	-3.24	regulation of alpha-beta T cell activation	biological process	GO:0046634	116	2	18204	49	SLC4A2,SYK
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	GSDME
3.908e-02	-3.24	1-phosphatidylinositol-3-kinase regulator activity	molecular function	GO:0046935	15	1	18094	48	PIK3R5
3.922e-02	-3.24	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	31	16828	46	CSF1R,ADCY7,DOCK2,PIK3CB,MYO1F,SLC4A2,PRKCD,DOCK1,PIK3R5,MICAL1,VAV3,WAS,ELMO1,PTPN6,PLCG2,NEK6,AKAP13,RHBDF2,IRF5,P2RY2,SYK,P2RY6,APOE,RIN3,DOCK8,ARHGAP33,DOCK10,WDFY4,SKAP1,PREX1,IPCEF1
3.930e-02	-3.24	RAB5B (RAB5B, member RAS oncogene family)	protein interactions	5869	122	2	19454	50	RIN3,PIK3CB
3.930e-02	-3.24	ELK1 (ETS transcription factor ELK1)	protein interactions	2002	122	2	19454	50	HIF1A,PLCG2
3.938e-02	-3.23	D-myo-inositol-5-phosphate metabolism	BIOCYC pathways	META_PWY-6367	9	1	902	4	PLCG2
3.939e-02	-3.23	actin filament	cellular component	GO:0005884	120	2	19108	50	MICAL1,WAS
3.943e-02	-3.23	human chr10q26.2	chromosome location	human chr10q26.2	21	1	26134	50	DOCK1
3.959e-02	-3.23	negative regulation of hemopoiesis	biological process	GO:1903707	117	2	18204	49	CD74,SLC4A2
3.959e-02	-3.23	cellular detoxification	biological process	GO:1990748	117	2	18204	49	IPCEF1,APOE
3.964e-02	-3.23	negative regulation of B cell mediated immunity	biological process	GO:0002713	15	1	18204	49	PTPN6
3.964e-02	-3.23	positive regulation of granulocyte macrophage colony-stimulating factor production	biological process	GO:0032725	15	1	18204	49	SYK
3.964e-02	-3.23	regulation of membrane invagination	biological process	GO:1905153	15	1	18204	49	PLCG2
3.964e-02	-3.23	positive regulation of hormone metabolic process	biological process	GO:0032352	15	1	18204	49	HIF1A
3.964e-02	-3.23	positive regulation of monocyte chemotactic protein-1 production	biological process	GO:0071639	15	1	18204	49	SYK
3.964e-02	-3.23	collagen-activated signaling pathway	biological process	GO:0038065	15	1	18204	49	SYK
3.964e-02	-3.23	columnar/cuboidal epithelial cell maturation	biological process	GO:0002069	15	1	18204	49	HIF1A
3.964e-02	-3.23	negative regulation of B cell apoptotic process	biological process	GO:0002903	15	1	18204	49	CD74
3.964e-02	-3.23	sphingosine-1-phosphate receptor signaling pathway	biological process	GO:0003376	15	1	18204	49	PIK3CB
3.964e-02	-3.23	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	1	18204	49	P2RY6
3.964e-02	-3.23	negative regulation of immunoglobulin mediated immune response	biological process	GO:0002890	15	1	18204	49	PTPN6
3.964e-02	-3.23	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	49	APOE
3.964e-02	-3.23	oxygen transport	biological process	GO:0015671	15	1	18204	49	IPCEF1
3.964e-02	-3.23	neutrophil activation involved in immune response	biological process	GO:0002283	15	1	18204	49	SYK
3.964e-02	-3.23	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902166	15	1	18204	49	CD74
3.964e-02	-3.23	negative regulation of DNA damage response, signal transduction by p53 class mediator	biological process	GO:0043518	15	1	18204	49	CD74
3.964e-02	-3.23	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	49	APOE
3.964e-02	-3.23	regulation of phagocytosis, engulfment	biological process	GO:0060099	15	1	18204	49	PLCG2
3.975e-02	-3.23	SMAD-like_dom_sf	interpro domains	IPR017855	15	1	18521	50	IRF5
3.975e-02	-3.23	PI3/4_kinase_CS	interpro domains	IPR018936	15	1	18521	50	PIK3CB
3.975e-02	-3.23	PI3/4_kinase_cat_sf	interpro domains	IPR036940	15	1	18521	50	PIK3CB
3.975e-02	-3.23	PI-PLC_fam	interpro domains	IPR001192	15	1	18521	50	PLCG2
3.975e-02	-3.23	CRISP-related	interpro domains	IPR001283	15	1	18521	50	GLIPR1
3.975e-02	-3.23	CAP_domain	interpro domains	IPR014044	15	1	18521	50	GLIPR1
3.975e-02	-3.23	CAP_sf	interpro domains	IPR035940	15	1	18521	50	GLIPR1
3.975e-02	-3.23	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	1	18521	50	PLCG2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	NRK
3.977e-02	-3.22	KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)	protein interactions	10008	294	3	19454	50	PIK3CB,RHBDF2,PRKCD
3.988e-02	-3.22	EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)	protein interactions	8891	123	2	19454	50	P2RY6,CD74
3.988e-02	-3.22	HHV8GK18_gp81 (ORF73)	protein interactions	4961527	123	2	19454	50	HIF1A,RGS14
3.988e-02	-3.22	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	4	10285	36	PIK3CB,SYK,VAV3,PLCG2
3.989e-02	-3.22	WH1	prosite domains	PS50229	11	1	12186	45	WAS
4.020e-02	-3.21	biological process involved in interaction with symbiont	biological process	GO:0051702	118	2	18204	49	CSF1R,APOE
4.035e-02	-3.21	EPO (erythropoietin)	protein interactions	2056	16	1	19454	50	HIF1A
4.035e-02	-3.21	KCNA6 (potassium voltage-gated channel subfamily A member 6)	protein interactions	3742	16	1	19454	50	SLC4A2
4.035e-02	-3.21	RASGRP3 (RAS guanyl releasing protein 3)	protein interactions	25780	16	1	19454	50	PRKCD
4.035e-02	-3.21	KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)	protein interactions	3761	16	1	19454	50	PRKCD
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	PLCG2
4.035e-02	-3.21	SELPLG (selectin P ligand)	protein interactions	6404	16	1	19454	50	SYK
4.035e-02	-3.21	PRICKLE4 (prickle planar cell polarity protein 4)	protein interactions	29964	16	1	19454	50	NEK6
4.035e-02	-3.21	TNFRSF25 (TNF receptor superfamily member 25)	protein interactions	8718	16	1	19454	50	PTPN6
4.035e-02	-3.21	TMEM88 (transmembrane protein 88)	protein interactions	92162	16	1	19454	50	MICAL1
4.047e-02	-3.21	TNK2 (tyrosine kinase non receptor 2)	protein interactions	10188	124	2	19454	50	WAS,NEK6
4.047e-02	-3.21	TM9SF3 (transmembrane 9 superfamily member 3)	protein interactions	56889	124	2	19454	50	P2RY6,P2RY2
4.047e-02	-3.21	RNF5 (ring finger protein 5)	protein interactions	6048	124	2	19454	50	P2RY2,HIF1A
4.047e-02	-3.21	ERLEC1 (endoplasmic reticulum lectin 1)	protein interactions	27248	124	2	19454	50	P2RY6,SEMA4A
4.055e-02	-3.21	parathyroid	COSMIC cancer mutations	parathyroid	476	4	16828	46	PRKCD,TBC1D8,DOCK2,PLCG2
4.076e-02	-3.20	TyrKc	smart domains	SM00219	80	2	9717	39	SYK,CSF1R
4.082e-02	-3.20	negative regulation of protein transport	biological process	GO:0051224	119	2	18204	49	RHBDF2,APOE
4.083e-02	-3.20	Oncostatin M Signaling Pathway	WikiPathways	WP2374	66	2	5310	26	PRKCD,HIF1A
4.083e-02	-3.20	AGE/RAGE pathway	WikiPathways	WP2324	66	2	5310	26	PRKCD,HIF1A
4.093e-02	-3.20	EPO signaling pathway	Pathway Interaction DB	epopathway	33	2	2226	22	PLCG2,PTPN6
4.113e-02	-3.19	ALDH3A2 (aldehyde dehydrogenase 3 family member A2)	protein interactions	224	298	3	19454	50	RHBDF2,P2RY6,RIN3
4.114e-02	-3.19	protein-containing complex binding	molecular function	GO:0044877	1772	9	18094	48	SBNO2,FYB1,SYK,MICAL1,DOCK2,APOE,MYO1F,CD74,PIK3R5
4.123e-02	-3.19	Eicosanoids	REACTOME pathways	R-HSA-211979	12	1	10285	36	TBXAS1
4.123e-02	-3.19	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	36	HIF1A
4.123e-02	-3.19	PECAM1 interactions	REACTOME pathways	R-HSA-210990	12	1	10285	36	PTPN6
4.134e-02	-3.19	PI-PLC-Y	pfam domains	PF00387	15	1	17795	50	PLCG2
4.134e-02	-3.19	CAP	pfam domains	PF00188	15	1	17795	50	GLIPR1
4.134e-02	-3.19	CNH	pfam domains	PF00780	15	1	17795	50	NRK
4.147e-02	-3.18	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	24	16828	46	MICAL1,VAV3,CSF1R,MYO1F,PIK3CB,DOCK2,SLC4A2,PRKCD,HIF1A,PIK3R5,DOCK1,DOCK8,SBNO2,DOCK10,SKAP1,WDFY4,GMIP,TBC1D8,NEK6,AKAP13,PARVG,SYK,RIN3,GLIPR1
4.163e-02	-3.18	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	48	ADCY7
4.163e-02	-3.18	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	molecular function	GO:0050664	16	1	18094	48	MICAL1
4.163e-02	-3.18	diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004697	16	1	18094	48	PRKCD
4.166e-02	-3.18	KCTD17 (potassium channel tetramerization domain containing 17)	protein interactions	79734	126	2	19454	50	RIN3,PLCG2
4.207e-02	-3.17	chloride transport	biological process	GO:0006821	121	2	18204	49	SLC4A2,P2RY6
4.207e-02	-3.17	positive regulation of T cell differentiation	biological process	GO:0045582	121	2	18204	49	SYK,CD74
4.223e-02	-3.16	asymmetric cell division	biological process	GO:0008356	16	1	18204	49	RGS14
4.223e-02	-3.16	positive regulation of autophagy of mitochondrion	biological process	GO:1903599	16	1	18204	49	HIF1A
4.223e-02	-3.16	cellular response to prostaglandin E stimulus	biological process	GO:0071380	16	1	18204	49	P2RY6
4.223e-02	-3.16	positive regulation of B cell differentiation	biological process	GO:0045579	16	1	18204	49	SYK
4.223e-02	-3.16	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	49	APOE
4.223e-02	-3.16	negative regulation of alpha-beta T cell proliferation	biological process	GO:0046642	16	1	18204	49	SLC4A2
4.223e-02	-3.16	positive regulation of response to tumor cell	biological process	GO:0002836	16	1	18204	49	GSDME
4.223e-02	-3.16	regulation of cell proliferation involved in kidney development	biological process	GO:1901722	16	1	18204	49	IL6R
4.223e-02	-3.16	lactate metabolic process	biological process	GO:0006089	16	1	18204	49	HIF1A
4.223e-02	-3.16	sphingolipid mediated signaling pathway	biological process	GO:0090520	16	1	18204	49	PIK3CB
4.223e-02	-3.16	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	49	APOE
4.223e-02	-3.16	response to lithium ion	biological process	GO:0010226	16	1	18204	49	ADCY7
4.223e-02	-3.16	intestinal epithelial cell development	biological process	GO:0060576	16	1	18204	49	HIF1A
4.223e-02	-3.16	positive regulation of immune response to tumor cell	biological process	GO:0002839	16	1	18204	49	GSDME
4.223e-02	-3.16	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	49	APOE
4.229e-02	-3.16	-	gene3d domains	3.30.450.200	13	1	14470	48	DENND1B
4.235e-02	-3.16	DENN_C	interpro domains	IPR043153	16	1	18521	50	DENND1B
4.235e-02	-3.16	uDENN_dom	interpro domains	IPR005113	16	1	18521	50	DENND1B
4.235e-02	-3.16	dDENN_dom	interpro domains	IPR005112	16	1	18521	50	DENND1B
4.248e-02	-3.16	femur	COSMIC cancer mutations	femur	1197	7	16828	46	RIN3,PREX1,P2RY2,WDFY4,AKAP13,RHBDF2,DOCK10
4.251e-02	-3.16	TRAF1 (TNF receptor associated factor 1)	protein interactions	7185	302	3	19454	50	VAV3,GIT2,TBC1D8
4.269e-02	-3.15	Insulin Signaling	WikiPathways	WP481	161	3	5310	26	ARHGAP33,PRKCD,PIK3CB
4.271e-02	-3.15	muscle cell differentiation	biological process	GO:0042692	289	3	18204	49	AKAP13,DOCK2,DOCK1
4.282e-02	-3.15	CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2)	protein interactions	10370	17	1	19454	50	HIF1A
4.282e-02	-3.15	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	50	APOE
4.282e-02	-3.15	PLB1 (phospholipase B1)	protein interactions	151056	17	1	19454	50	RIN3
4.282e-02	-3.15	SLAMF6 (SLAM family member 6)	protein interactions	114836	17	1	19454	50	PTPN6
4.282e-02	-3.15	FAM131C (family with sequence similarity 131 member C)	protein interactions	348487	17	1	19454	50	RHBDF2
4.282e-02	-3.15	RIMBP3C (RIMS binding protein 3C)	protein interactions	150221	17	1	19454	50	NEK6
4.282e-02	-3.15	SAT2 (spermidine/spermine N1-acetyltransferase family member 2)	protein interactions	112483	17	1	19454	50	HIF1A
4.282e-02	-3.15	EPB42 (erythrocyte membrane protein band 4.2)	protein interactions	2038	17	1	19454	50	SLC4A2
4.282e-02	-3.15	Kif2c (kinesin family member 2C)	protein interactions	73804	17	1	19454	50	SLC4A2
4.286e-02	-3.15	TACSTD2 (tumor associated calcium signal transducer 2)	protein interactions	4070	128	2	19454	50	GSDME,TBC1D8
4.286e-02	-3.15	PPIB (peptidylprolyl isomerase B)	protein interactions	5479	303	3	19454	50	DOCK8,IRF5,PREX1
4.286e-02	-3.15	EBNA1BP2 (EBNA1 binding protein 2)	protein interactions	10969	303	3	19454	50	PTPN6,SYK,GMIP
4.287e-02	-3.15	normal	COSMIC cancer mutations	normal	16	1	16828	46	CSF1R
4.295e-02	-3.15	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	4	16828	46	IPCEF1,WDFY4,DOCK8,ELMO1
4.295e-02	-3.15	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	4	16828	46	IPCEF1,WDFY4,ELMO1,DOCK8
4.311e-02	-3.14	human chr3q22.3	chromosome location	human chr3q22.3	23	1	26134	50	PIK3CB
4.312e-02	-3.14	regulation of multicellular organismal development	biological process	GO:2000026	1484	8	18204	49	RGS14,HIF1A,PIK3CB,SLC4A2,CD74,PTPN6,SYK,SEMA4A
4.325e-02	-3.14	miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma	WikiPathways	WP3593	9	1	5310	26	HIF1A
4.330e-02	-3.14	WH2	smart domains	SM00246	11	1	9717	39	WAS
4.330e-02	-3.14	WH1	smart domains	SM00461	11	1	9717	39	WAS
4.346e-02	-3.14	PLD1 (phospholipase D1)	protein interactions	5337	129	2	19454	50	HIF1A,PLCG2
4.346e-02	-3.14	EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)	protein interactions	8890	129	2	19454	50	P2RY6,CD74
4.349e-02	-3.14	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	4	16828	46	PRKCD,SYK,NEK6,CSF1R
4.358e-02	-3.13	MHC class II protein complex	cellular component	GO:0042613	17	1	19108	50	CD74
4.364e-02	-3.13	centriolar satellite	cellular component	GO:0034451	127	2	19108	50	NEK6,PIK3R5
4.381e-02	-3.13	TYRKINASE	prints domains	PR00109	98	2	5227	18	SYK,NEK6
4.381e-02	-3.13	glycerophospholipid metabolic process	biological process	GO:0006650	292	3	18204	49	PIK3CB,PIK3R5,PLCG2
4.385e-02	-3.13	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	26	16828	46	AKAP13,EHBP1L1,CD74,IRF5,RIN3,P2RY2,SYK,P2RY6,DOCK10,WDFY4,SBNO2,DOCK8,PREX1,ARHGAP27,IPCEF1,ADCY7,DOCK2,PIK3CB,MYO1F,CSF1R,PIK3R5,DOCK1,SLC4A2,TBXAS1,MICAL1,ELMO1
4.385e-02	-3.13	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	26	16828	46	DOCK10,WDFY4,DOCK8,SBNO2,ARHGAP27,PREX1,IPCEF1,EHBP1L1,AKAP13,IRF5,CD74,RIN3,P2RY2,SYK,P2RY6,TBXAS1,MICAL1,ELMO1,ADCY7,PIK3CB,MYO1F,DOCK2,CSF1R,PIK3R5,DOCK1,SLC4A2
4.404e-02	-3.12	uDENN	pfam domains	PF03456	16	1	17795	50	DENND1B
4.407e-02	-3.12	YIPF5 (Yip1 domain family member 5)	protein interactions	81555	130	2	19454	50	P2RY2,P2RY6
4.415e-02	-3.12	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	22	16828	46	TBC1D8,CSF1R,EHBP1L1,AKAP13,PIK3CB,DOCK2,SLC4A2,PARVG,APOE,GLIPR1,DOCK1,RIN3,MICAL1,DOCK8,SBNO2,DOCK10,VAV3,SKAP1,WDFY4,PTPN6,ELMO1,PLCG2
4.417e-02	-3.12	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	48	PTPN6
4.417e-02	-3.12	GDP-dissociation inhibitor activity	molecular function	GO:0005092	17	1	18094	48	RGS14
4.417e-02	-3.12	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	48	PTPN6
4.433e-02	-3.12	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	12	16828	46	PLCG2,VAV3,ARHGAP33,RIN3,P2RY6,PRKCD,SYK,P2RY2,MYO1F,DOCK2,ADCY7,AKAP13
4.448e-02	-3.11	cytoskeleton	cellular component	GO:0005856	2412	11	19108	50	FYB1,NEK6,PIK3R5,AKAP13,ARHGAP33,PARVG,WAS,RGS14,MYO1F,MICAL1,DOCK2
4.459e-02	-3.11	FCGR activation	REACTOME pathways	R-HSA-2029481	13	1	10285	36	SYK
4.461e-02	-3.11	regulation of cell-matrix adhesion	biological process	GO:0001952	125	2	18204	49	SKAP1,PIK3CB
4.461e-02	-3.11	memory	biological process	GO:0007613	125	2	18204	49	APOE,RGS14
4.461e-02	-3.11	phosphatidylinositol biosynthetic process	biological process	GO:0006661	125	2	18204	49	PIK3CB,PLCG2
4.461e-02	-3.11	mammary gland development	biological process	GO:0030879	125	2	18204	49	HIF1A,CSF1R
4.468e-02	-3.11	TBCD (tubulin folding cofactor D)	protein interactions	6904	131	2	19454	50	RIN3,HIF1A
4.468e-02	-3.11	membrane protein complex	cellular component	GO:0098796	1261	7	19108	50	PIK3R5,SYK,CD74,PTPN6,SKAP1,PIK3CB,IL6R
4.479e-02	-3.11	lower_third	COSMIC cancer mutations	lower_third	7961	28	16828	46	PARVG,SYK,P2RY6,RIN3,AKAP13,PREX1,ARHGAP27,ARHGAP33,DOCK10,WDFY4,SKAP1,SLC4A2,RGS14,PRKCD,HIF1A,DOCK1,PIK3R5,CSF1R,ADCY7,GIT2,DOCK2,PIK3CB,MYO1F,ELMO1,PLCG2,MICAL1,TBXAS1,VAV3
4.481e-02	-3.11	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	49	IL6R
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	CD74
4.481e-02	-3.11	negative regulation of vascular endothelial growth factor signaling pathway	biological process	GO:1900747	17	1	18204	49	PIK3CB
4.481e-02	-3.11	regulation of amyloid fibril formation	biological process	GO:1905906	17	1	18204	49	APOE
4.481e-02	-3.11	axonal transport of mitochondrion	biological process	GO:0019896	17	1	18204	49	HIF1A
4.481e-02	-3.11	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	49	APOE
4.481e-02	-3.11	monocyte differentiation	biological process	GO:0030224	17	1	18204	49	CSF1R
4.481e-02	-3.11	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	49	APOE
4.481e-02	-3.11	negative regulation of humoral immune response	biological process	GO:0002921	17	1	18204	49	PTPN6
4.481e-02	-3.11	regulation of integrin activation	biological process	GO:0033623	17	1	18204	49	SKAP1
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	P2RY2
4.481e-02	-3.11	regulation of excitatory synapse assembly	biological process	GO:1904889	17	1	18204	49	SEMA4A
4.481e-02	-3.11	regulation of plasma membrane organization	biological process	GO:1903729	17	1	18204	49	PRKCD
4.481e-02	-3.11	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	49	APOE
4.481e-02	-3.11	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902165	17	1	18204	49	CD74
4.481e-02	-3.11	negative regulation of receptor internalization	biological process	GO:0002091	17	1	18204	49	RIN3
4.481e-02	-3.11	regulation of dendritic cell cytokine production	biological process	GO:0002730	17	1	18204	49	PLCG2
4.481e-02	-3.11	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	49	HIF1A
4.481e-02	-3.11	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	49	APOE
4.481e-02	-3.11	reverse cholesterol transport	biological process	GO:0043691	17	1	18204	49	APOE
4.481e-02	-3.11	CD4-positive, alpha-beta T cell lineage commitment	biological process	GO:0043373	17	1	18204	49	IL6R
4.484e-02	-3.10	cell-cell junction	cellular component	GO:0005911	513	4	19108	50	SKAP1,PRKCD,PTPN6,WAS
4.487e-02	-3.10	non_seminoma	COSMIC cancer mutations	non_seminoma	492	4	16828	46	NEK6,PRKCD,SYK,CSF1R
4.490e-02	-3.10	cAMP signaling pathway	KEGG pathways	ko04024	198	3	7161	29	PIK3CB,ADCY7,VAV3
4.490e-02	-3.10	cAMP signaling pathway	KEGG pathways	hsa04024	198	3	7161	29	VAV3,ADCY7,PIK3CB
4.493e-02	-3.10	Thyroglobulin_1_sf	interpro domains	IPR036857	17	1	18521	50	CD74
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY7
4.493e-02	-3.10	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	1	18521	50	PLCG2
4.493e-02	-3.10	Thyroglobulin_1	interpro domains	IPR000716	17	1	18521	50	CD74
4.493e-02	-3.10	RGS_subdom1/3	interpro domains	IPR024066	17	1	18521	50	RGS14
4.493e-02	-3.10	cDENN_dom	interpro domains	IPR001194	17	1	18521	50	DENND1B
4.493e-02	-3.10	PAC	interpro domains	IPR001610	17	1	18521	50	HIF1A
4.516e-02	-3.10	skin-ear-malignant_melanoma	COSMIC cancer mutations	skin-ear-malignant_melanoma	124	2	16828	46	WDFY4,PIK3CB
4.525e-02	-3.10	response to ethanol	biological process	GO:0045471	126	2	18204	49	TBXAS1,ADCY7
4.529e-02	-3.09	BEX4 (brain expressed X-linked 4)	protein interactions	56271	18	1	19454	50	PRKCD
4.529e-02	-3.09	FAM120AOS (family with sequence similarity 120 member A opposite strand)	protein interactions	158293	18	1	19454	50	MICAL1
4.529e-02	-3.09	CSRP3 (cysteine and glycine rich protein 3)	protein interactions	8048	18	1	19454	50	RIN3
4.529e-02	-3.09	Chmp6 (charged multivesicular body protein 6)	protein interactions	208092	18	1	19454	50	PTPN6
4.529e-02	-3.09	PCDHA11 (protocadherin alpha 11)	protein interactions	56138	18	1	19454	50	RIN3
4.529e-02	-3.09	ZKSCAN7 (zinc finger with KRAB and SCAN domains 7)	protein interactions	55888	18	1	19454	50	PLCG2
4.529e-02	-3.09	TM4SF20 (transmembrane 4 L six family member 20)	protein interactions	79853	18	1	19454	50	CD74
4.529e-02	-3.09	GALM (galactose mutarotase)	protein interactions	130589	18	1	19454	50	AKAP13
4.529e-02	-3.09	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	50	APOE
4.529e-02	-3.09	DCAF17 (DDB1 and CUL4 associated factor 17)	protein interactions	80067	18	1	19454	50	PREX1
4.531e-02	-3.09	positive regulation of nervous system development	biological process	GO:0051962	296	3	18204	49	RGS14,HIF1A,SEMA4A
4.531e-02	-3.09	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	40	16828	46	MICAL1,VAV3,WAS,PTPN6,ELMO1,PLCG2,CSF1R,ADCY7,DOCK2,GIT2,PIK3CB,MYO1F,SLC4A2,PRKCD,RGS14,HIF1A,PIK3R5,DOCK1,SBNO2,DOCK8,ARHGAP33,DOCK10,WDFY4,GMIP,SKAP1,PREX1,ARHGAP27,IPCEF1,TBC1D8,AKAP13,EHBP1L1,RHBDF2,CD74,PARVG,P2RY2,SYK,P2RY6,APOE,GLIPR1,RIN3
4.547e-02	-3.09	Epstein-Barr virus infection	KEGG pathways	hsa05169	199	3	7161	29	PIK3CB,PLCG2,SYK
4.547e-02	-3.09	Epstein-Barr virus infection	KEGG pathways	ko05169	199	3	7161	29	PIK3CB,SYK,PLCG2
4.558e-02	-3.09	FAS (CD95) signaling pathway	Pathway Interaction DB	faspathway	35	2	2226	22	PIK3CB,SYK
4.579e-02	-3.08	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	26	16828	46	PREX1,ARHGAP27,IPCEF1,ELMO1,DOCK10,WDFY4,GMIP,SKAP1,VAV3,SBNO2,DENND1B,HIF1A,APOE,RIN3,PIK3R5,DOCK1,PARVG,SLC4A2,PRKCD,AKAP13,ADCY7,DOCK2,GIT2,MYO1F,PIK3CB,CSF1R
4.590e-02	-3.08	cellular response to toxic substance	biological process	GO:0097237	127	2	18204	49	APOE,IPCEF1
4.591e-02	-3.08	CDC25B (cell division cycle 25B)	protein interactions	994	133	2	19454	50	PIK3CB,PRKCD
4.596e-02	-3.08	ErbB signaling pathway	KEGG pathways	hsa04012	85	2	7161	29	PIK3CB,PLCG2
4.596e-02	-3.08	ErbB signaling pathway	KEGG pathways	ko04012	85	2	7161	29	PLCG2,PIK3CB
4.615e-02	-3.08	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	46	16828	46	PARVG,EHBP1L1,IRF5,WDFY4,DOCK8,DENND1B,SLC4A2,RGS14,ADCY7,GIT2,MYO1F,PTPN6,ELMO1,VAV3,APOE,RIN3,GLIPR1,P2RY2,P2RY6,SYK,AKAP13,RHBDF2,IL6R,CD74,TBC1D8,NEK6,PREX1,ARHGAP27,IPCEF1,ARHGAP33,SEMA4A,DOCK10,GMIP,SKAP1,SBNO2,HIF1A,PIK3R5,DOCK1,PRKCD,DOCK2,PIK3CB,CSF1R,PLCG2,WAS,TBXAS1,MICAL1
4.621e-02	-3.07	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	8	18094	48	NRK,PRKCD,PIK3CB,NEK6,CSF1R,MYO1F,SYK,ADCY7
4.652e-02	-3.07	response to inorganic substance	biological process	GO:0010035	505	4	18204	49	PLCG2,ADCY7,HIF1A,PRKCD
4.652e-02	-3.07	monoatomic cation homeostasis	biological process	GO:0055080	505	4	18204	49	HIF1A,APOE,PIK3CB,SLC4A2
4.655e-02	-3.07	regulation of protein binding	biological process	GO:0043393	128	2	18204	49	PRKCD,APOE
4.671e-02	-3.06	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	48	APOE
4.673e-02	-3.06	DENN	pfam domains	PF02141	17	1	17795	50	DENND1B
4.673e-02	-3.06	Thyroglobulin_1	pfam domains	PF00086	17	1	17795	50	CD74
4.673e-02	-3.06	PI-PLC-X	pfam domains	PF00388	17	1	17795	50	PLCG2
4.698e-02	-3.06	PI3_4_KINASE_1	prosite domains	PS00915	13	1	12186	45	PIK3CB
4.704e-02	-3.06	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	45	CSF1R,SYK
4.720e-02	-3.05	response to organophosphorus	biological process	GO:0046683	129	2	18204	49	P2RY2,P2RY6
4.738e-02	-3.05	regulation of clathrin-dependent endocytosis	biological process	GO:2000369	18	1	18204	49	PIK3CB
4.738e-02	-3.05	regulation of granulocyte macrophage colony-stimulating factor production	biological process	GO:0032645	18	1	18204	49	SYK
4.738e-02	-3.05	angiogenesis involved in wound healing	biological process	GO:0060055	18	1	18204	49	PIK3CB
4.738e-02	-3.05	positive regulation of neuroinflammatory response	biological process	GO:0150078	18	1	18204	49	PLCG2
4.738e-02	-3.05	antifungal innate immune response	biological process	GO:0061760	18	1	18204	49	PLCG2
4.738e-02	-3.05	morphogenesis of an epithelial fold	biological process	GO:0060571	18	1	18204	49	HIF1A
4.738e-02	-3.05	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	49	DOCK10
4.738e-02	-3.05	gamma-delta T cell activation	biological process	GO:0046629	18	1	18204	49	SYK
4.738e-02	-3.05	regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002923	18	1	18204	49	PTPN6
4.738e-02	-3.05	cell-cell junction maintenance	biological process	GO:0045217	18	1	18204	49	CSF1R
4.738e-02	-3.05	positive regulation of vascular endothelial growth factor receptor signaling pathway	biological process	GO:0030949	18	1	18204	49	HIF1A
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY7
4.752e-02	-3.05	PI3/4_kinase_cat_dom	interpro domains	IPR000403	18	1	18521	50	PIK3CB
4.752e-02	-3.05	CRIB_dom	interpro domains	IPR000095	18	1	18521	50	WAS
4.752e-02	-3.05	WH2_dom	interpro domains	IPR003124	18	1	18521	50	WAS
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY7
4.774e-02	-3.04	SLITRK3 (SLIT and NTRK like family member 3)	protein interactions	22865	19	1	19454	50	RHBDF2
4.774e-02	-3.04	PEX2 (peroxisomal biogenesis factor 2)	protein interactions	5828	19	1	19454	50	PTPN6
4.774e-02	-3.04	CSF1 (colony stimulating factor 1)	protein interactions	1435	19	1	19454	50	CSF1R
4.774e-02	-3.04	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	50	PRKCD
4.774e-02	-3.04	ZNF197 (zinc finger protein 197)	protein interactions	10168	19	1	19454	50	HIF1A
4.774e-02	-3.04	RCVRN (recoverin)	protein interactions	5957	19	1	19454	50	GIT2
4.774e-02	-3.04	SIT1 (signaling threshold regulating transmembrane adaptor 1)	protein interactions	27240	19	1	19454	50	SYK
4.774e-02	-3.04	PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2)	protein interactions	57546	19	1	19454	50	PRKCD
4.774e-02	-3.04	PPRC1 (PPARG related coactivator 1)	protein interactions	23082	19	1	19454	50	PRKCD
4.779e-02	-3.04	PYGB (glycogen phosphorylase B)	protein interactions	5834	136	2	19454	50	PRKCD,FYB1
4.779e-02	-3.04	SNX9 (sorting nexin 9)	protein interactions	51429	136	2	19454	50	WAS,PIK3R5
4.779e-02	-3.04	NAF1 (nuclear assembly factor 1 ribonucleoprotein)	protein interactions	92345	136	2	19454	50	SYK,RIN3
4.791e-02	-3.04	LDHA (lactate dehydrogenase A)	protein interactions	3939	317	3	19454	50	DOCK8,HIF1A,RIN3
4.791e-02	-3.04	RANBP2 (RAN binding protein 2)	protein interactions	5903	317	3	19454	50	AKAP13,RHBDF2,WAS
4.793e-02	-3.04	Regulation of IFNG signaling	REACTOME pathways	R-HSA-877312	14	1	10285	36	PTPN6
4.793e-02	-3.04	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	36	DOCK1
4.794e-02	-3.04	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	26	APOE
4.797e-02	-3.04	Signaling events mediated by TCPTP	Pathway Interaction DB	tcptp_pathway	36	2	2226	22	CSF1R,PIK3CB
4.828e-02	-3.03	TRIM54 (tripartite motif containing 54)	protein interactions	57159	318	3	19454	50	NEK6,ELMO1,PARVG
4.852e-02	-3.03	digestive tract development	biological process	GO:0048565	131	2	18204	49	HIF1A,SLC4A2
4.864e-02	-3.02	Phosphatidylinositol 3-/4-kinase, catalytic domain	gene3d domains	1.10.1070.11	15	1	14470	48	PIK3CB
4.864e-02	-3.02	CAP	gene3d domains	3.40.33.10	15	1	14470	48	GLIPR1
4.864e-02	-3.02	-	gene3d domains	2.60.200.10	15	1	14470	48	IRF5
4.865e-02	-3.02	GCN1 (GCN1 activator of EIF2AK4)	protein interactions	10985	319	3	19454	50	NEK6,HIF1A,P2RY6
4.916e-02	-3.01	defense response to bacterium	biological process	GO:0042742	306	3	18204	49	IL6R,SYK,PRKCD
4.937e-02	-3.01	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	4	18204	49	SKAP1,PLCG2,SEMA4A,SYK
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	EHBP1L1,HIF1A,PRKCD
4.941e-02	-3.01	PI3_PI4_kinase	pfam domains	PF00454	18	1	17795	50	PIK3CB
4.941e-02	-3.01	Guanylate_cyc	pfam domains	PF00211	18	1	17795	50	ADCY7
4.945e-02	-3.01	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	4	16828	46	CSF1R,SYK,PRKCD,NEK6
4.968e-02	-3.00	MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking)	protein interactions	23041	139	2	19454	50	P2RY6,HIF1A
4.968e-02	-3.00	HOMEZ (homeobox and leucine zipper encoding)	protein interactions	57594	139	2	19454	50	NEK6,PARVG
4.985e-02	-3.00	positive regulation of adaptive immune response	biological process	GO:0002821	133	2	18204	49	DENND1B,SKAP1
4.985e-02	-3.00	positive regulation of endothelial cell migration	biological process	GO:0010595	133	2	18204	49	PIK3CB,HIF1A
4.992e-02	-3.00	Longevity regulating pathway	KEGG pathways	hsa04211	89	2	7161	29	ADCY7,PIK3CB
4.995e-02	-3.00	alpha-beta T cell lineage commitment	biological process	GO:0002363	19	1	18204	49	IL6R
4.995e-02	-3.00	adenylate cyclase-activating adrenergic receptor signaling pathway	biological process	GO:0071880	19	1	18204	49	AKAP13
4.995e-02	-3.00	leukotriene biosynthetic process	biological process	GO:0019370	19	1	18204	49	SYK
4.995e-02	-3.00	positive regulation of reactive oxygen species biosynthetic process	biological process	GO:1903428	19	1	18204	49	PLCG2
4.995e-02	-3.00	chloride ion homeostasis	biological process	GO:0055064	19	1	18204	49	TBXAS1
4.995e-02	-3.00	regulation of amyloid-beta clearance	biological process	GO:1900221	19	1	18204	49	APOE
4.995e-02	-3.00	positive regulation of macrophage chemotaxis	biological process	GO:0010759	19	1	18204	49	CSF1R
4.995e-02	-3.00	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	49	APOE
4.995e-02	-3.00	regulation of protein neddylation	biological process	GO:2000434	19	1	18204	49	HIF1A
4.995e-02	-3.00	regulation of B cell apoptotic process	biological process	GO:0002902	19	1	18204	49	CD74
4.995e-02	-3.00	positive regulation of bone resorption	biological process	GO:0045780	19	1	18204	49	SYK
4.995e-02	-3.00	regulation of mast cell activation	biological process	GO:0033003	19	1	18204	49	PTPN6
4.995e-02	-3.00	production of molecular mediator involved in inflammatory response	biological process	GO:0002532	19	1	18204	49	SYK
4.995e-02	-3.00	negative regulation of cellular response to vascular endothelial growth factor stimulus	biological process	GO:1902548	19	1	18204	49	PIK3CB
4.995e-02	-3.00	response to hydroperoxide	biological process	GO:0033194	19	1	18204	49	PRKCD