Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
4.167e-12	-26.20	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	30	16828	49	NRG3,GPM6A,PLCB1,NEBL,SOX5,PARD3B,CNTN1,HIF3A,SLC1A2,LRP1B,KALRN,NTRK2,LSAMP,PRKCA,GPC5,HPSE2,ARHGEF4,TRPM3,CTNND2,TSHZ2,RFX4,TRPS1,FMN2,FYN,EYA2,EFEMP1,PARD3,ADCY2,MAP3K5,RYR3
1.133e-11	-25.20	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	29	16828	49	FYN,TRPS1,RFX4,FMN2,CTNND2,TSHZ2,GPC5,HPSE2,ARHGEF4,RYR3,EFEMP1,ADCY2,PARD3,MAP3K5,EYA2,NEBL,PLCB1,SOX5,PARD3B,GPM6A,NRG3,PRKCA,LSAMP,NTRK2,SLC1A2,LRP1B,KALRN,CNTN1,HIF3A
4.268e-11	-23.88	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	47	16828	49	MSI2,NRG3,NEBL,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,SLC1A2,ABCA1,PRKCA,LSAMP,GPC5,ARHGEF4,CTNND2,RFX4,CLU,FMN2,FYN,PTPRZ1,DTNA,ADCY2,SORBS1,AHCYL1,GPM6A,PLCB1,SOX5,DCLK2,PARD3B,PITPNC1,HIF3A,KALRN,LRP1B,NTRK2,HPSE2,ABLIM1,MACF1,TRPM3,TSHZ2,NPAS3,TRPS1,BMPR1B,EYA2,EFEMP1,PARD3,MAP3K5,RYR3
2.292e-10	-22.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	16	16828	49	LSAMP,NTRK2,RYR3,LRP1B,KALRN,ATP1A2,PARD3,MAP3K5,ADCY2,SLC1A2,TSHZ2,NRG3,GPC5,HPSE2,SOX5,PLCB1
2.330e-10	-22.18	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	19	16828	49	SLC7A11,ATP1A2,KALRN,LRP1B,PARD3,ADCY2,MAP3K5,SLC1A2,LSAMP,PRKCA,NTRK2,RYR3,NRG3,HPSE2,SOX5,DCLK2,NPAS3,FYN,BMPR1B
2.330e-10	-22.18	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	19	16828	49	NRG3,HPSE2,FYN,BMPR1B,SOX5,DCLK2,NPAS3,SLC7A11,LSAMP,NTRK2,PRKCA,RYR3,ATP1A2,KALRN,LRP1B,MAP3K5,ADCY2,PARD3,SLC1A2
2.547e-09	-19.79	cerebellum	COSMIC cancer mutations	cerebellum	769	15	16828	49	LRP1B,PARD3,NTRK2,RYR3,NRCAM,NEBL,NPAS3,PLCB1,PARD3B,PTPRZ1,GPC5,HPSE2,NRG3,ABLIM1,CTNND2
2.612e-09	-19.76	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	20	16828	49	RYR3,NTRK2,LSAMP,PARD3,ADCY2,KALRN,LRP1B,SLC7A11,EYA2,RORA,PLCB1,NEBL,FMN2,SOX5,CTNND2,TSHZ2,HPSE2,AHCYL1,GPC5,NRG3
2.612e-09	-19.76	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	20	16828	49	NRG3,GPC5,AHCYL1,HPSE2,TSHZ2,CTNND2,SOX5,FMN2,NEBL,PLCB1,RORA,EYA2,SLC7A11,LRP1B,KALRN,PARD3,ADCY2,NTRK2,LSAMP,RYR3
2.933e-09	-19.65	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	14	16828	49	CTNND2,HPSE2,ABLIM1,NRG3,PTPRZ1,NEBL,PLCB1,NPAS3,PARD3B,NRCAM,RYR3,NTRK2,PARD3,LRP1B
2.991e-09	-19.63	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	14	16828	49	ABLIM1,NRG3,HPSE2,CTNND2,PARD3B,PLCB1,NEBL,NPAS3,PTPRZ1,NRCAM,PARD3,LRP1B,RYR3,NTRK2
3.883e-09	-19.37	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	23	16828	49	SLC1A2,LRP1B,KALRN,NTRK2,LSAMP,SLC7A11,CNTN1,PLCB1,SOX5,NRG3,GPM6A,PARD3,ADCY2,MAP3K5,RYR3,NPAS3,FMN2,RFX4,BMPR1B,HPSE2,GPC5,CTNND2,TSHZ2
3.883e-09	-19.37	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	23	16828	49	SOX5,PLCB1,GPM6A,NRG3,LSAMP,NTRK2,LRP1B,KALRN,SLC1A2,CNTN1,SLC7A11,BMPR1B,RFX4,FMN2,NPAS3,TSHZ2,CTNND2,GPC5,HPSE2,RYR3,ADCY2,PARD3,MAP3K5
4.778e-09	-19.16	central nervous system development	biological process	GO:0007417	995	16	18204	50	RORA,BMPR1B,ATP1A2,NRCAM,PLCB1,SLC7A11,PTPRZ1,DCLK2,CNTN1,RFX4,MSI2,NRG3,FYN,CLU,SLC1A2,NTRK2
5.459e-09	-19.03	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	29	16828	49	PLCB1,PARD3B,PITPNC1,NRG3,MSI2,LRP1B,KALRN,PRKCA,LSAMP,NTRK2,NRCAM,SLC7A11,NPAS3,CLU,FMN2,BMPR1B,PTPRZ1,GPC5,HPSE2,MACF1,TRPM3,CTNND2,TSHZ2,EFEMP1,ADCY2,PARD3,MAP3K5,RYR3,DTNA
5.459e-09	-19.03	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	29	16828	49	HPSE2,GPC5,CTNND2,TRPM3,MACF1,TSHZ2,NPAS3,FMN2,CLU,BMPR1B,PTPRZ1,DTNA,EFEMP1,MAP3K5,PARD3,ADCY2,RYR3,MSI2,NRG3,PLCB1,PARD3B,PITPNC1,NRCAM,SLC7A11,LRP1B,KALRN,PRKCA,LSAMP,NTRK2
1.166e-08	-18.27	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	31	16828	49	SLC1A2,LRP1B,ATP1A2,KALRN,LSAMP,NTRK2,PRKCA,RORA,CNTN1,NEBL,PLCB1,SOX5,NRG3,GPM6A,EFEMP1,MAP3K5,PARD3,ADCY2,RYR3,EYA2,DTNA,AQP4,FMN2,CLU,TRPS1,HPSE2,GPC5,ARHGEF4,CTNND2,MACF1,TSHZ2
1.540e-08	-17.99	nervous system development	biological process	GO:0007399	2185	22	18204	50	PARD3,RFX4,GPM6A,CNTN1,LSAMP,NRG3,MSI2,FYN,CTNND2,CLU,NTRK2,SOX5,KALRN,SLC1A2,ATP1A2,RORA,BMPR1B,NRCAM,PLCB1,SLC7A11,PTPRZ1,DCLK2
1.790e-08	-17.84	lymph_node	COSMIC cancer mutations	lymph_node	1703	20	16828	49	DTNA,LSAMP,NTRK2,PRKCA,RYR3,ABCA1,LRP1B,PARD3,MAP3K5,GPM6A,TRPM3,CTNND2,NRG3,GPC5,FYN,TRPS1,SOX5,PARD3B,PLCB1,NEBL
2.522e-08	-17.50	cell periphery	cellular component	GO:0071944	6020	35	19108	50	NTRK2,HIF3A,GPM6A,ARHGEF4,PTPRZ1,PRKCA,HPSE2,EFEMP1,SLC7A11,ABCA1,AHCYL1,FYN,GPC5,CTNND2,NRG3,TRPM3,MACF1,LRP1B,PARD3B,SORBS1,CNTN1,DTNA,CLU,SLC1A2,FMN2,NRCAM,MAP3K5,BMPR1B,PARD3,ATP1A2,MAPK10,LSAMP,RYR3,AQP4,ADCY2
2.815e-08	-17.39	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	40	16828	49	RYR3,SORBS1,MAP3K5,PARD3,ADCY2,EYA2,PTPRZ1,FYN,RFX4,TRPS1,FMN2,NPAS3,TSHZ2,TRPM3,MACF1,CTNND2,ARHGEF4,ABLIM1,GPC5,HPSE2,PRKCA,LSAMP,NTRK2,LRP1B,KALRN,ABCA1,SLC1A2,GLIS3,CNTN1,SLC7A11,RORA,PITPNC1,DCLK2,SOX5,PARD3B,PLCB1,NEBL,GPM6A,NRG3,AHCYL1
2.915e-08	-17.35	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	12	16828	49	LSAMP,RYR3,LRP1B,ADCY2,PLCB1,SOX5,FMN2,CTNND2,GPM6A,GPC5,NRG3,ARHGEF4
5.314e-08	-16.75	system development	biological process	GO:0048731	3533	27	18204	50	PRKCA,TRPS1,NRG3,LSAMP,GPM6A,CNTN1,SOX5,CLU,EFEMP1,CTNND2,RORA,BMPR1B,DCLK2,MSI2,FYN,PARD3,RFX4,SLC1A2,NTRK2,KALRN,NRCAM,PLCB1,ATP1A2,NEBL,SLC7A11,PTPRZ1,HIF3A
5.448e-08	-16.73	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	28	16828	49	NRG3,GPM6A,NEBL,PLCB1,SOX5,RORA,CNTN1,SLC1A2,KALRN,ATP1A2,LRP1B,PRKCA,LSAMP,HPSE2,GPC5,ARHGEF4,CTNND2,MACF1,TSHZ2,AQP4,FMN2,CLU,EYA2,EFEMP1,ADCY2,PARD3,MAP3K5,RYR3
5.824e-08	-16.66	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	41	16828	49	AHCYL1,NRG3,GPM6A,NEBL,PLCB1,SOX5,DCLK2,NRCAM,RORA,SLC7A11,CNTN1,GLIS3,SLC1A2,ATP1A2,ABCA1,KALRN,LRP1B,LSAMP,PRKCA,NTRK2,HPSE2,GPC5,ARHGEF4,ABLIM1,CTNND2,MACF1,TRPM3,TSHZ2,FMN2,TRPS1,RFX4,CLU,BMPR1B,FYN,PTPRZ1,EYA2,EFEMP1,ADCY2,MAP3K5,PARD3,RYR3
6.243e-08	-16.59	plasma membrane	cellular component	GO:0005886	5538	33	19108	50	DTNA,SORBS1,CNTN1,SLC1A2,FMN2,TRPM3,PARD3B,MACF1,LRP1B,AQP4,ADCY2,LSAMP,RYR3,BMPR1B,PARD3,NRCAM,MAP3K5,ATP1A2,MAPK10,PRKCA,PTPRZ1,ABCA1,SLC7A11,HPSE2,GPM6A,HIF3A,ARHGEF4,NTRK2,FYN,AHCYL1,NRG3,GPC5,CTNND2
1.344e-07	-15.82	multicellular organism development	biological process	GO:0007275	3957	28	18204	50	PTPRZ1,HIF3A,SLC7A11,NEBL,ATP1A2,PLCB1,NRCAM,KALRN,NTRK2,SLC1A2,RFX4,PARD3,EYA2,FYN,MSI2,DCLK2,BMPR1B,RORA,CTNND2,EFEMP1,CLU,SOX5,CNTN1,GPM6A,LSAMP,NRG3,PRKCA,TRPS1
1.593e-07	-15.65	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	49	16828	49	EYA2,RYR3,EFEMP1,MAP3K5,PARD3,TRPM3,MACF1,TSHZ2,HPSE2,ABLIM1,BMPR1B,NPAS3,AQP4,TRPS1,HIF3A,NTRK2,LRP1B,ATP1A2,KALRN,GPM6A,AHCYL1,PITPNC1,PLCB1,DCLK2,SOX5,PARD3B,DTNA,SORBS1,ADCY2,CTNND2,GPC5,ARHGEF4,FYN,PTPRZ1,CLU,RFX4,FMN2,CNTN1,SLC7A11,GLIS3,RORA,NRCAM,PRKCA,LSAMP,SLC1A2,ABCA1,NRG3,MSI2,NEBL
1.895e-07	-15.48	FLOT1 (flotillin 1)	protein interactions	10211	453	10	19454	50	ABLIM1,ARHGEF4,PARD3,FYN,FMN2,ABCA1,SOX5,DTNA,MACF1,SORBS1
2.059e-07	-15.40	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	28	16828	49	NTRK2,LSAMP,KALRN,ABCA1,LRP1B,SLC1A2,GLIS3,CNTN1,HIF3A,RORA,NRCAM,SOX5,NEBL,PLCB1,GPM6A,NRG3,AHCYL1,RYR3,ADCY2,PARD3,EYA2,PTPRZ1,BMPR1B,FMN2,TSHZ2,CTNND2,GPC5,HPSE2
2.059e-07	-15.40	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	28	16828	49	EYA2,ADCY2,PARD3,RYR3,GPC5,HPSE2,CTNND2,TSHZ2,FMN2,BMPR1B,PTPRZ1,RORA,NRCAM,CNTN1,HIF3A,GLIS3,SLC1A2,ABCA1,LRP1B,KALRN,LSAMP,NTRK2,AHCYL1,NRG3,GPM6A,PLCB1,NEBL,SOX5
3.377e-07	-14.90	mouth	COSMIC cancer mutations	mouth	9004	43	16828	49	NRCAM,RORA,HIF3A,CNTN1,SLC1A2,LRP1B,ATP1A2,ABCA1,KALRN,PRKCA,NTRK2,LSAMP,NRG3,GPM6A,PLCB1,NEBL,PARD3B,SOX5,DCLK2,PITPNC1,EYA2,DTNA,EFEMP1,MAP3K5,ADCY2,PARD3,SORBS1,RYR3,HPSE2,GPC5,ABLIM1,ARHGEF4,CTNND2,TRPM3,MACF1,TSHZ2,NPAS3,FMN2,CLU,RFX4,TRPS1,FYN,PTPRZ1
3.611e-07	-14.83	humerus	COSMIC cancer mutations	humerus	546	11	16828	49	GPC5,HIF3A,GPM6A,NEBL,PARD3B,ADCY2,FMN2,SOX5,ABCA1,LRP1B,KALRN
3.817e-07	-14.78	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	6	16828	49	ARHGEF4,LRP1B,PLCB1,LSAMP,GPM6A,CTNND2
4.322e-07	-14.65	brain development	biological process	GO:0007420	724	12	18204	50	RFX4,ATP1A2,CNTN1,RORA,FYN,NRG3,PLCB1,NRCAM,SLC7A11,NTRK2,DCLK2,SLC1A2
4.354e-07	-14.65	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	20	19108	50	CNTN1,PRKCA,CLU,DTNA,ABLIM1,FMN2,SLC1A2,SLC7A11,MACF1,NTRK2,GPM6A,ARHGEF4,FYN,CTNND2,AQP4,ADCY2,NRCAM,BMPR1B,PARD3,ATP1A2
5.280e-07	-14.45	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	14	19454	50	TRPS1,CNTN1,SORBS1,CLU,ABLIM1,ATP1A2,LSAMP,AQP4,TRPM3,GPM6A,MACF1,PTPRZ1,PLCB1,MSI2
6.193e-07	-14.29	anatomical structure morphogenesis	biological process	GO:0009653	2225	20	18204	50	HIF3A,PTPRZ1,NEBL,BMPR1B,ABLIM1,RORA,NRCAM,CTNND2,CLU,EFEMP1,KALRN,SOX5,NTRK2,PARD3,CNTN1,EYA2,GPM6A,FYN,NRG3,PRKCA
7.144e-07	-14.15	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	36	16828	49	PARD3,MAP3K5,SORBS1,ADCY2,RYR3,EYA2,AQP4,NPAS3,FMN2,TRPS1,BMPR1B,FYN,PTPRZ1,HPSE2,GPC5,ABLIM1,CTNND2,MACF1,TRPM3,TSHZ2,ABCA1,KALRN,ATP1A2,LRP1B,PRKCA,HIF3A,CNTN1,GLIS3,NEBL,PLCB1,PARD3B,DCLK2,SOX5,PITPNC1,NRG3,GPM6A
7.803e-07	-14.06	telencephalon development	biological process	GO:0021537	276	8	18204	50	PLCB1,NRG3,ATP1A2,RFX4,SLC1A2,DCLK2,NTRK2,SLC7A11
8.252e-07	-14.01	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	38	16828	49	FYN,PTPRZ1,AQP4,NPAS3,RFX4,TRPS1,CLU,FMN2,MACF1,TRPM3,CTNND2,TSHZ2,HPSE2,RYR3,ADCY2,MAP3K5,PARD3,EYA2,PITPNC1,PLCB1,NEBL,DCLK2,SOX5,PARD3B,AHCYL1,NRG3,NTRK2,LSAMP,PRKCA,SLC1A2,KALRN,ABCA1,LRP1B,ATP1A2,CNTN1,SLC7A11,RORA,NRCAM
8.252e-07	-14.01	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	38	16828	49	SLC7A11,CNTN1,NRCAM,RORA,LSAMP,PRKCA,NTRK2,ATP1A2,LRP1B,KALRN,ABCA1,SLC1A2,NRG3,AHCYL1,PITPNC1,PARD3B,DCLK2,SOX5,NEBL,PLCB1,EYA2,RYR3,PARD3,MAP3K5,ADCY2,TSHZ2,CTNND2,TRPM3,MACF1,HPSE2,PTPRZ1,FYN,FMN2,CLU,RFX4,TRPS1,NPAS3,AQP4
8.774e-07	-13.95	head development	biological process	GO:0060322	774	12	18204	50	SLC7A11,DCLK2,SLC1A2,NTRK2,CNTN1,RORA,RFX4,ATP1A2,PLCB1,NRCAM,FYN,NRG3
9.113e-07	-13.91	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	10	16828	49	GPC5,NRG3,TRPM3,CTNND2,GPM6A,PLCB1,LRP1B,LSAMP,PRKCA,RYR3
9.499e-07	-13.87	cell projection	cellular component	GO:0042995	2398	20	19108	50	SLC7A11,SLC1A2,FMN2,ABLIM1,PRKCA,DTNA,CLU,CNTN1,ARHGEF4,GPM6A,NTRK2,MACF1,ADCY2,AQP4,CTNND2,FYN,ATP1A2,PARD3,BMPR1B,NRCAM
9.618e-07	-13.85	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	29	16828	49	FMN2,RFX4,TRPS1,CLU,PTPRZ1,FYN,ARHGEF4,ABLIM1,TSHZ2,CTNND2,MACF1,TRPM3,MAP3K5,PARD3,ADCY2,RYR3,DTNA,SOX5,NRG3,AHCYL1,GPM6A,ABCA1,KALRN,LRP1B,ATP1A2,GLIS3,HIF3A,SLC7A11,CNTN1
9.618e-07	-13.85	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	29	16828	49	ABLIM1,ARHGEF4,TSHZ2,CTNND2,MACF1,TRPM3,FMN2,TRPS1,RFX4,CLU,PTPRZ1,FYN,DTNA,ADCY2,MAP3K5,PARD3,RYR3,NRG3,AHCYL1,GPM6A,SOX5,GLIS3,SLC7A11,HIF3A,CNTN1,ABCA1,KALRN,ATP1A2,LRP1B
9.889e-07	-13.83	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	15	16828	49	HPSE2,AHCYL1,GPC5,NRG3,CTNND2,AQP4,SOX5,RORA,EFEMP1,ADCY2,PARD3,LRP1B,ABCA1,PRKCA,LSAMP
1.189e-06	-13.64	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	37	16828	49	RYR3,MAP3K5,ADCY2,SORBS1,PARD3,DTNA,EYA2,PTPRZ1,FMN2,TRPS1,RFX4,TSHZ2,CTNND2,MACF1,TRPM3,ARHGEF4,ABLIM1,GPC5,LSAMP,PRKCA,LRP1B,ATP1A2,ABCA1,KALRN,SLC1A2,HIF3A,CNTN1,NRCAM,RORA,PITPNC1,PARD3B,SOX5,DCLK2,NEBL,PLCB1,GPM6A,NRG3
1.452e-06	-13.44	forebrain development	biological process	GO:0030900	408	9	18204	50	PLCB1,NRG3,FYN,ATP1A2,RFX4,SLC1A2,DCLK2,NTRK2,SLC7A11
1.482e-06	-13.42	cell communication	biological process	GO:0007154	5010	30	18204	50	MAPK10,ATP1A2,NRCAM,PLCB1,FMN2,PITPNC1,EYA2,PARD3,AHCYL1,FYN,MACF1,SLC1A2,NTRK2,KALRN,RORA,BMPR1B,SORBS1,MAP3K5,DCLK2,CNTN1,DTNA,ADCY2,ARHGEF4,PRKCA,NRG3,EFEMP1,CLU,CTNND2,ABCA1,RYR3
1.715e-06	-13.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	15	16828	49	RYR3,NTRK2,ADCY2,LRP1B,ABCA1,TSHZ2,GPM6A,CTNND2,MACF1,ABLIM1,NRG3,HPSE2,FMN2,TRPS1,NEBL
1.715e-06	-13.28	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	15	16828	49	ADCY2,ABCA1,LRP1B,RYR3,NTRK2,HPSE2,ABLIM1,NRG3,CTNND2,MACF1,TSHZ2,GPM6A,NEBL,FMN2,TRPS1
1.742e-06	-13.26	pharynx	COSMIC cancer mutations	pharynx	2696	22	16828	49	RYR3,PRKCA,NTRK2,SLC1A2,EFEMP1,SORBS1,LRP1B,ATP1A2,DTNA,NRCAM,PITPNC1,PTPRZ1,NPAS3,FMN2,PARD3B,RFX4,CLU,CTNND2,MACF1,TSHZ2,GPC5,NRG3
1.826e-06	-13.21	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	45	16828	49	ADCY2,SORBS1,DTNA,FYN,PTPRZ1,RFX4,FMN2,CTNND2,GPC5,ARHGEF4,LSAMP,PRKCA,SLC1A2,ABCA1,CNTN1,GLIS3,RORA,NRCAM,NEBL,NRG3,RYR3,EFEMP1,PARD3,MAP3K5,EYA2,BMPR1B,NPAS3,TRPS1,MACF1,TRPM3,TSHZ2,HPSE2,ABLIM1,NTRK2,ATP1A2,KALRN,LRP1B,HIF3A,PITPNC1,PLCB1,DCLK2,SOX5,PARD3B,GPM6A,AHCYL1
1.826e-06	-13.21	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	45	16828	49	PLCB1,PARD3B,SOX5,DCLK2,PITPNC1,AHCYL1,GPM6A,LRP1B,KALRN,ATP1A2,NTRK2,HIF3A,NPAS3,TRPS1,BMPR1B,HPSE2,ABLIM1,MACF1,TRPM3,TSHZ2,EFEMP1,MAP3K5,PARD3,RYR3,EYA2,NEBL,NRG3,SLC1A2,ABCA1,LSAMP,PRKCA,NRCAM,RORA,CNTN1,GLIS3,FMN2,RFX4,FYN,PTPRZ1,GPC5,ARHGEF4,CTNND2,ADCY2,SORBS1,DTNA
1.953e-06	-13.15	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	27	16828	49	RYR3,PARD3,ADCY2,PTPRZ1,TRPS1,RFX4,FMN2,AQP4,NPAS3,TSHZ2,MACF1,CTNND2,ARHGEF4,NTRK2,LRP1B,ATP1A2,ABCA1,KALRN,SLC1A2,GLIS3,HIF3A,PITPNC1,PARD3B,PLCB1,NEBL,GPM6A,AHCYL1
1.964e-06	-13.14	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	27	16828	49	MACF1,CTNND2,TSHZ2,ARHGEF4,PTPRZ1,NPAS3,AQP4,RFX4,TRPS1,FMN2,RYR3,PARD3,ADCY2,GPM6A,AHCYL1,PITPNC1,PLCB1,NEBL,PARD3B,HIF3A,GLIS3,NTRK2,SLC1A2,ABCA1,KALRN,LRP1B,ATP1A2
2.308e-06	-12.98	neuronal action potential propagation	biological process	GO:0019227	10	3	18204	50	ATP1A2,NTRK2,NRCAM
2.308e-06	-12.98	action potential propagation	biological process	GO:0098870	10	3	18204	50	NTRK2,NRCAM,ATP1A2
2.341e-06	-12.96	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	27	16828	49	PTPRZ1,NPAS3,AQP4,FMN2,RFX4,TRPS1,CTNND2,MACF1,TSHZ2,ARHGEF4,RYR3,PARD3,ADCY2,PITPNC1,NEBL,PLCB1,PARD3B,GPM6A,AHCYL1,NTRK2,SLC1A2,ATP1A2,ABCA1,LRP1B,KALRN,HIF3A,GLIS3
2.349e-06	-12.96	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	23	16828	49	ABCA1,LRP1B,KALRN,ATP1A2,NTRK2,PRKCA,NRCAM,CNTN1,SLC7A11,HIF3A,NEBL,NRG3,MSI2,ADCY2,MAP3K5,PARD3,EYA2,NPAS3,FMN2,FYN,BMPR1B,MACF1,TRPM3
2.349e-06	-12.96	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	23	16828	49	MSI2,NRG3,NEBL,SLC7A11,HIF3A,CNTN1,NRCAM,PRKCA,NTRK2,ATP1A2,LRP1B,KALRN,ABCA1,MACF1,TRPM3,BMPR1B,FYN,FMN2,NPAS3,EYA2,ADCY2,MAP3K5,PARD3
2.570e-06	-12.87	glial cell projection	cellular component	GO:0097386	37	4	19108	50	FYN,SLC1A2,AQP4,SLC7A11
3.055e-06	-12.70	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	13	16828	49	PARD3,ADCY2,LRP1B,EFEMP1,LSAMP,PRKCA,RORA,SOX5,NRG3,HPSE2,AHCYL1,GPC5,CTNND2
3.202e-06	-12.65	plasma membrane region	cellular component	GO:0098590	1278	14	19108	50	SORBS1,CNTN1,SLC1A2,SLC7A11,ABCA1,GPM6A,ARHGEF4,PARD3B,MACF1,AHCYL1,AQP4,PARD3,NRCAM,ATP1A2
3.262e-06	-12.63	nodular	COSMIC cancer mutations	nodular	1515	16	16828	49	GLIS3,HIF3A,CNTN1,KALRN,ATP1A2,LRP1B,NTRK2,ABLIM1,CTNND2,MACF1,FMN2,DCLK2,NEBL,NPAS3,PLCB1,PTPRZ1
3.540e-06	-12.55	trunk	COSMIC cancer mutations	trunk	3554	25	16828	49	PTPRZ1,TRPS1,NPAS3,CTNND2,MACF1,ABLIM1,HPSE2,RYR3,MAP3K5,PARD3,EYA2,DCLK2,SOX5,NEBL,PLCB1,NRG3,NTRK2,LSAMP,ATP1A2,LRP1B,ABCA1,KALRN,GLIS3,HIF3A,NRCAM
3.560e-06	-12.55	anatomical structure development	biological process	GO:0048856	5207	30	18204	50	TRPS1,PRKCA,LSAMP,NRG3,GPM6A,CNTN1,SOX5,EFEMP1,CLU,CTNND2,RORA,ABLIM1,BMPR1B,DCLK2,MSI2,FYN,EYA2,PARD3,RFX4,SLC1A2,NTRK2,KALRN,NRCAM,PLCB1,ATP1A2,FMN2,NEBL,SLC7A11,PTPRZ1,HIF3A
3.587e-06	-12.54	multicellular organismal process	biological process	GO:0032501	6177	33	18204	50	DCLK2,RORA,ABLIM1,BMPR1B,RYR3,ABCA1,SOX5,EFEMP1,CLU,CTNND2,TRPS1,PRKCA,LSAMP,NRG3,GPM6A,CNTN1,DTNA,NEBL,SLC7A11,PTPRZ1,HIF3A,NRCAM,PLCB1,ATP1A2,SLC1A2,NTRK2,KALRN,MSI2,FYN,EYA2,PARD3,AQP4,RFX4
3.650e-06	-12.52	MAPT (microtubule associated protein tau)	protein interactions	4137	948	12	19454	50	SORBS1,NEBL,CLU,ABLIM1,LSAMP,ATP1A2,GPM6A,PRKCA,MAPK10,CTNND2,SLC1A2,FYN
3.969e-06	-12.44	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	37	16828	49	FYN,BMPR1B,CLU,RFX4,FMN2,MACF1,CTNND2,TSHZ2,GPC5,HPSE2,ARHGEF4,ABLIM1,RYR3,EFEMP1,PARD3,ADCY2,MAP3K5,EYA2,PLCB1,NEBL,SOX5,GPM6A,AHCYL1,NRG3,LSAMP,NTRK2,PRKCA,SLC1A2,ABCA1,KALRN,ATP1A2,LRP1B,CNTN1,SLC7A11,GLIS3,RORA,NRCAM
4.182e-06	-12.38	signal transduction	biological process	GO:0007165	4637	28	18204	50	DCLK2,SORBS1,RORA,BMPR1B,MAP3K5,CTNND2,EFEMP1,CLU,RYR3,ABCA1,DTNA,CNTN1,NRG3,ADCY2,ARHGEF4,PRKCA,FMN2,ATP1A2,MAPK10,PLCB1,MACF1,NTRK2,KALRN,PARD3,AHCYL1,PITPNC1,EYA2,FYN
4.793e-06	-12.25	signaling	biological process	GO:0023052	4968	29	18204	50	NRG3,PRKCA,ARHGEF4,ADCY2,DTNA,CNTN1,ABCA1,RYR3,CTNND2,CLU,EFEMP1,MAP3K5,SORBS1,BMPR1B,RORA,DCLK2,FYN,PARD3,AHCYL1,EYA2,PITPNC1,KALRN,NTRK2,SLC1A2,MACF1,PLCB1,ATP1A2,MAPK10,FMN2
4.959e-06	-12.21	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	37	16828	49	ADCY2,MAP3K5,PARD3,EFEMP1,RYR3,EYA2,FMN2,CLU,RFX4,PTPRZ1,BMPR1B,FYN,ARHGEF4,ABLIM1,HPSE2,GPC5,TSHZ2,CTNND2,MACF1,KALRN,ABCA1,LRP1B,SLC1A2,NTRK2,LSAMP,PRKCA,RORA,GLIS3,SLC7A11,CNTN1,PARD3B,SOX5,PLCB1,NEBL,NRG3,AHCYL1,GPM6A
5.159e-06	-12.17	adenoma	COSMIC cancer mutations	adenoma	2873	22	16828	49	NEBL,DCLK2,SOX5,GPM6A,NTRK2,PRKCA,ABCA1,KALRN,LRP1B,HIF3A,BMPR1B,PTPRZ1,NPAS3,CTNND2,MACF1,TRPM3,HPSE2,GPC5,RYR3,ADCY2,PARD3,EYA2
6.057e-06	-12.01	neuron projection morphogenesis	biological process	GO:0048812	486	9	18204	50	KALRN,CTNND2,PTPRZ1,FYN,NRCAM,PARD3,BMPR1B,CNTN1,GPM6A
6.347e-06	-11.97	CNTN1 (contactin 1)	protein interactions	1272	47	4	19454	50	GPM6A,FYN,CNTN1,PTPRZ1
6.532e-06	-11.94	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	32	16828	49	NRG3,GPM6A,PARD3B,SOX5,PLCB1,NEBL,NRCAM,CNTN1,KALRN,ABCA1,ATP1A2,LRP1B,NTRK2,LSAMP,HPSE2,GPC5,TSHZ2,CTNND2,MACF1,TRPM3,FMN2,CLU,TRPS1,NPAS3,PTPRZ1,EYA2,DTNA,ADCY2,MAP3K5,SORBS1,PARD3,RYR3
6.532e-06	-11.94	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	32	16828	49	HPSE2,GPC5,CTNND2,MACF1,TRPM3,TSHZ2,NPAS3,FMN2,CLU,TRPS1,PTPRZ1,EYA2,DTNA,MAP3K5,ADCY2,PARD3,SORBS1,RYR3,NRG3,GPM6A,PLCB1,NEBL,PARD3B,SOX5,NRCAM,CNTN1,ABCA1,KALRN,ATP1A2,LRP1B,NTRK2,LSAMP
6.578e-06	-11.93	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	9	18204	50	PARD3,GPM6A,BMPR1B,CNTN1,FYN,NRCAM,CTNND2,PTPRZ1,KALRN
7.125e-06	-11.85	Par3_HAL_N_term	pfam domains	PF12053	2	2	17795	48	PARD3B,PARD3
7.138e-06	-11.85	cell projection morphogenesis	biological process	GO:0048858	496	9	18204	50	KALRN,CTNND2,PTPRZ1,NRCAM,FYN,GPM6A,CNTN1,BMPR1B,PARD3
7.143e-06	-11.85	Par3/HAL_N	interpro domains	IPR021922	2	2	18521	50	PARD3,PARD3B
9.205e-06	-11.60	neurogenesis	biological process	GO:0022008	1334	14	18204	50	PARD3,CNTN1,GPM6A,FYN,CTNND2,CLU,KALRN,NTRK2,SOX5,BMPR1B,RORA,NRCAM,PTPRZ1,DCLK2
1.014e-05	-11.50	generation of neurons	biological process	GO:0048699	1158	13	18204	50	CTNND2,KALRN,NTRK2,SOX5,PARD3,CNTN1,GPM6A,FYN,PTPRZ1,DCLK2,BMPR1B,RORA,NRCAM
1.198e-05	-11.33	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	14	16828	49	PTPRZ1,NPAS3,PLCB1,NEBL,DCLK2,MACF1,CTNND2,ABLIM1,NTRK2,ATP1A2,KALRN,LRP1B,HIF3A,GLIS3
1.229e-05	-11.31	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	6	19454	50	ATP1A2,PARD3,RYR3,PRKCA,ABCA1,DTNA
1.335e-05	-11.22	regulation of chondrocyte differentiation	biological process	GO:0032330	53	4	18204	50	SOX5,TRPS1,EFEMP1,BMPR1B
1.353e-05	-11.21	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	7	19454	50	FMN2,MACF1,DTNA,PARD3,PLCB1,AHCYL1,ABLIM1
1.421e-05	-11.16	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	4	10285	33	PLCB1,ADCY2,AHCYL1,PRKCA
1.437e-05	-11.15	cell morphogenesis	biological process	GO:0000902	687	10	18204	50	CLU,PTPRZ1,CTNND2,KALRN,GPM6A,BMPR1B,CNTN1,PARD3,NRCAM,FYN
1.547e-05	-11.08	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	4	10285	33	PLCB1,AHCYL1,ADCY2,PRKCA
1.586e-05	-11.05	astrocyte projection	cellular component	GO:0097449	19	3	19108	50	SLC1A2,SLC7A11,AQP4
1.642e-05	-11.02	synapse	cellular component	GO:0045202	1473	14	19108	50	KALRN,ATP1A2,NRCAM,NRG3,CTNND2,FYN,GPM6A,NTRK2,PLCB1,SLC1A2,DTNA,CLU,CNTN1,PTPRZ1
1.668e-05	-11.00	neuron development	biological process	GO:0048666	859	11	18204	50	PARD3,BMPR1B,CNTN1,GPM6A,FYN,NRCAM,CTNND2,PTPRZ1,KALRN,NTRK2,DCLK2
1.909e-05	-10.87	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	8	19454	50	KALRN,CTNND2,PARD3,FYN,FMN2,PRKCA,MACF1,DTNA
2.047e-05	-10.80	cellular component organization	biological process	GO:0016043	5636	30	18204	50	DCLK2,SORBS1,BMPR1B,HPSE2,ABLIM1,CTNND2,CLU,ABCA1,RYR3,TRPM3,CNTN1,GPM6A,NRG3,PRKCA,ARHGEF4,PTPRZ1,NEBL,PARD3B,FMN2,NRCAM,MACF1,KALRN,SLC1A2,AQP4,RFX4,PARD3,AHCYL1,EYA2,PITPNC1,FYN
2.194e-05	-10.73	Salivary secretion	KEGG pathways	ko04970	90	5	7161	28	PLCB1,RYR3,PRKCA,ADCY2,ATP1A2
2.194e-05	-10.73	Salivary secretion	KEGG pathways	hsa04970	90	5	7161	28	ATP1A2,PRKCA,ADCY2,RYR3,PLCB1
2.463e-05	-10.61	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	5	19454	50	DTNA,FYN,PARD3,NTRK2,ABLIM1
2.497e-05	-10.60	protein kinase activity	molecular function	GO:0004672	577	9	18094	50	DCLK2,PRKCA,FYN,KALRN,EFEMP1,NTRK2,MAPK10,BMPR1B,MAP3K5
2.529e-05	-10.59	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	8	18204	50	NRCAM,FYN,CNTN1,BMPR1B,PARD3,KALRN,CTNND2,PTPRZ1
2.555e-05	-10.57	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	23	16828	49	NRG3,PITPNC1,PLCB1,NEBL,GLIS3,PRKCA,ABCA1,ATP1A2,KALRN,LRP1B,CTNND2,TRPM3,MACF1,TSHZ2,GPC5,ARHGEF4,PTPRZ1,FMN2,RFX4,EFEMP1,ADCY2,MAP3K5,PARD3
2.612e-05	-10.55	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	33	16828	49	ABCA1,LRP1B,KALRN,ATP1A2,PRKCA,NTRK2,RORA,NRCAM,CNTN1,PLCB1,SOX5,DCLK2,PITPNC1,AHCYL1,NRG3,MAP3K5,PARD3,ADCY2,RYR3,CLU,RFX4,FMN2,FYN,BMPR1B,PTPRZ1,GPC5,HPSE2,ARHGEF4,ABLIM1,MACF1,TRPM3,CTNND2,TSHZ2
2.612e-05	-10.55	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	33	16828	49	ATP1A2,LRP1B,ABCA1,KALRN,NTRK2,PRKCA,RORA,NRCAM,CNTN1,SOX5,DCLK2,PLCB1,PITPNC1,NRG3,AHCYL1,PARD3,MAP3K5,ADCY2,RYR3,CLU,RFX4,FMN2,PTPRZ1,FYN,BMPR1B,ABLIM1,ARHGEF4,GPC5,HPSE2,TSHZ2,MACF1,TRPM3,CTNND2
2.638e-05	-10.54	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	32	16828	49	GPM6A,AHCYL1,NRG3,NEBL,PLCB1,PARD3B,HIF3A,SLC7A11,GLIS3,NRCAM,NTRK2,ATP1A2,ABCA1,KALRN,LRP1B,MACF1,TRPM3,TSHZ2,GPC5,HPSE2,ABLIM1,FYN,PTPRZ1,TRPS1,RFX4,CLU,FMN2,DTNA,MAP3K5,PARD3,SORBS1,ADCY2
2.658e-05	-10.54	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	32	16828	49	PARD3B,PLCB1,NEBL,NRG3,AHCYL1,GPM6A,ATP1A2,ABCA1,KALRN,LRP1B,NTRK2,NRCAM,GLIS3,SLC7A11,HIF3A,FMN2,RFX4,TRPS1,CLU,PTPRZ1,FYN,ABLIM1,HPSE2,GPC5,TSHZ2,TRPM3,MACF1,MAP3K5,ADCY2,SORBS1,PARD3,DTNA
2.674e-05	-10.53	neuron projection	cellular component	GO:0043005	1331	13	19108	50	NTRK2,GPM6A,SLC1A2,CNTN1,CLU,DTNA,ATP1A2,NRCAM,PARD3,BMPR1B,CTNND2,ADCY2,FYN
2.682e-05	-10.53	neuron differentiation	biological process	GO:0030182	1081	12	18204	50	FYN,PARD3,GPM6A,CNTN1,NTRK2,KALRN,CTNND2,NRCAM,RORA,BMPR1B,DCLK2,PTPRZ1
2.759e-05	-10.50	I-set	pfam domains	PF07679	132	5	17795	48	CNTN1,NRCAM,NTRK2,LSAMP,KALRN
2.773e-05	-10.49	developmental process	biological process	GO:0032502	5716	30	18204	50	MSI2,FYN,EYA2,PARD3,RFX4,SLC1A2,NTRK2,KALRN,NRCAM,PLCB1,ATP1A2,FMN2,NEBL,SLC7A11,PTPRZ1,HIF3A,PRKCA,TRPS1,NRG3,LSAMP,GPM6A,CNTN1,SOX5,CLU,EFEMP1,CTNND2,RORA,ABLIM1,BMPR1B,DCLK2
2.781e-05	-10.49	cell junction	cellular component	GO:0030054	2224	17	19108	50	KALRN,ATP1A2,PARD3,NRCAM,NRG3,CTNND2,FYN,PARD3B,GPM6A,NTRK2,PLCB1,SLC1A2,CLU,DTNA,PTPRZ1,CNTN1,SORBS1
2.792e-05	-10.49	Ig_I-set	interpro domains	IPR013098	132	5	18521	50	NRCAM,LSAMP,CNTN1,KALRN,NTRK2
2.836e-05	-10.47	SH3_domain	interpro domains	IPR001452	222	6	18521	50	MACF1,NEBL,KALRN,ARHGEF4,FYN,SORBS1
2.908e-05	-10.45	bone	COSMIC cancer mutations	bone	8157	38	16828	49	RYR3,ADCY2,PARD3,SORBS1,MAP3K5,DTNA,PTPRZ1,FYN,FMN2,TRPS1,NPAS3,TSHZ2,CTNND2,TRPM3,MACF1,ARHGEF4,ABLIM1,HPSE2,GPC5,NTRK2,LSAMP,ATP1A2,ABCA1,KALRN,LRP1B,GLIS3,SLC7A11,HIF3A,CNTN1,NRCAM,RORA,PARD3B,DCLK2,SOX5,PLCB1,NEBL,GPM6A,NRG3
3.292e-05	-10.32	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	33	16828	49	EYA2,EFEMP1,PARD3,MAP3K5,SORBS1,ADCY2,RYR3,GPC5,HPSE2,ABLIM1,ARHGEF4,TRPM3,MACF1,CTNND2,NPAS3,RFX4,CLU,TRPS1,FMN2,RORA,NRCAM,CNTN1,HIF3A,SLC1A2,KALRN,ABCA1,LRP1B,NRG3,GPM6A,PLCB1,SOX5,PARD3B,PITPNC1
3.402e-05	-10.29	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	17	16828	49	RORA,LSAMP,PARD3,LRP1B,MACF1,TRPM3,GPM6A,GPC5,ABLIM1,MSI2,NRG3,PTPRZ1,AQP4,PLCB1,NEBL,FMN2,TRPS1
3.484e-05	-10.26	OCLN (occludin)	protein interactions	100506658	495	8	19454	50	DTNA,MACF1,NTRK2,PRKCA,PARD3,FMN2,ABLIM1,EFEMP1
3.513e-05	-10.26	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	15	16828	49	SORBS1,ABCA1,KALRN,CNTN1,DTNA,NRCAM,RORA,PTPRZ1,PLCB1,PARD3B,FMN2,CTNND2,MACF1,ABLIM1,ARHGEF4
3.513e-05	-10.26	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	15	16828	49	ABCA1,KALRN,SORBS1,RORA,NRCAM,CNTN1,DTNA,PLCB1,FMN2,PARD3B,PTPRZ1,ARHGEF4,ABLIM1,MACF1,CTNND2
3.908e-05	-10.15	protein binding	molecular function	GO:0005515	13983	49	18094	50	RFX4,SOX5,FMN2,FYN,RORA,SORBS1,LRP1B,PRKCA,LSAMP,DCLK2,TRPS1,AQP4,NRG3,NPAS3,GLIS3,TSHZ2,PITPNC1,CNTN1,HIF3A,CLU,NTRK2,GPM6A,ABCA1,CTNND2,SLC7A11,ARHGEF4,NRCAM,EYA2,MAP3K5,MSI2,PARD3B,DTNA,ATP1A2,HPSE2,SLC1A2,KALRN,PLCB1,ADCY2,ABLIM1,NEBL,PARD3,RYR3,BMPR1B,MACF1,EFEMP1,GPC5,AHCYL1,PTPRZ1,MAPK10
3.954e-05	-10.14	postsynapse	cellular component	GO:0098794	646	9	19108	50	CTNND2,FYN,CNTN1,GPM6A,KALRN,ATP1A2,NTRK2,PLCB1,NRCAM
3.961e-05	-10.14	Prot_kinase_dom	interpro domains	IPR000719	480	8	18521	50	NTRK2,MAP3K5,DCLK2,PRKCA,KALRN,BMPR1B,FYN,MAPK10
3.982e-05	-10.13	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	31	16828	49	RYR3,MAP3K5,SORBS1,PARD3,ADCY2,TSHZ2,CTNND2,MACF1,TRPM3,ARHGEF4,HPSE2,GPC5,PTPRZ1,FMN2,CLU,TRPS1,AQP4,NPAS3,GLIS3,RORA,LSAMP,NTRK2,ABCA1,LRP1B,SLC1A2,GPM6A,NRG3,PARD3B,SOX5,NEBL,PLCB1
4.330e-05	-10.05	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	19	16828	49	PLCB1,SOX5,FMN2,FYN,PTPRZ1,GPC5,HPSE2,NRG3,CTNND2,GPM6A,TSHZ2,KALRN,LRP1B,PARD3,ADCY2,PRKCA,LSAMP,RYR3,RORA
4.547e-05	-10.00	cellular component organization or biogenesis	biological process	GO:0071840	5850	30	18204	50	NRCAM,PTPRZ1,PARD3B,NEBL,FMN2,EYA2,PITPNC1,RFX4,AQP4,AHCYL1,PARD3,FYN,MACF1,SLC1A2,KALRN,HPSE2,BMPR1B,ABLIM1,SORBS1,DCLK2,CNTN1,TRPM3,GPM6A,ARHGEF4,PRKCA,NRG3,CLU,CTNND2,RYR3,ABCA1
4.767e-05	-9.95	regulation of cartilage development	biological process	GO:0061035	73	4	18204	50	BMPR1B,EFEMP1,TRPS1,SOX5
4.975e-05	-9.91	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	7	19454	50	CNTN1,MACF1,NRCAM,PRKCA,BMPR1B,PARD3,FYN
4.979e-05	-9.91	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	25	16828	49	TSHZ2,MACF1,CTNND2,ABLIM1,ARHGEF4,GPC5,RFX4,TRPS1,FMN2,EYA2,PARD3,MAP3K5,NRG3,AHCYL1,PARD3B,NEBL,PLCB1,CNTN1,RORA,NRCAM,PRKCA,KALRN,LRP1B,ATP1A2,SLC1A2
5.006e-05	-9.90	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	12	18204	50	PARD3,RFX4,ABLIM1,GPM6A,CNTN1,BMPR1B,FYN,NRCAM,ARHGEF4,CTNND2,PTPRZ1,KALRN
5.463e-05	-9.81	cellular component assembly	biological process	GO:0022607	2472	18	18204	50	FMN2,NEBL,NRCAM,SORBS1,ABLIM1,SLC1A2,ABCA1,RYR3,CLU,NRG3,PRKCA,ARHGEF4,PARD3,AQP4,RFX4,GPM6A,TRPM3,CNTN1
5.741e-05	-9.77	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	14	16828	49	NRG3,GPC5,TSHZ2,MACF1,FMN2,PARD3B,NPAS3,PTPRZ1,NRCAM,DTNA,LRP1B,SORBS1,EFEMP1,RYR3
5.951e-05	-9.73	axonogenesis	biological process	GO:0007409	366	7	18204	50	FYN,NRCAM,PARD3,BMPR1B,CNTN1,KALRN,PTPRZ1
6.216e-05	-9.69	protein phosphorylation	biological process	GO:0006468	503	8	18204	50	EFEMP1,NTRK2,KALRN,MAPK10,BMPR1B,MAP3K5,FYN,PRKCA
6.328e-05	-9.67	learning	biological process	GO:0007612	154	5	18204	50	PLCB1,FYN,NTRK2,ATP1A2,SLC7A11
6.407e-05	-9.66	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	12	16828	49	RYR3,SLC1A2,LRP1B,KALRN,PARD3,ADCY2,TSHZ2,GPC5,NRG3,PLCB1,SOX5,FMN2
6.426e-05	-9.65	face	COSMIC cancer mutations	face	2139	17	16828	49	PLCB1,NEBL,AQP4,FMN2,TRPS1,PTPRZ1,GPC5,ABLIM1,MSI2,NRG3,MACF1,TRPM3,GPM6A,PARD3,LRP1B,LSAMP,RORA
6.437e-05	-9.65	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	7	18521	50	NTRK2,DCLK2,MAP3K5,KALRN,BMPR1B,PRKCA,FYN
6.641e-05	-9.62	brainstem	COSMIC cancer mutations	brainstem	3102	21	16828	49	RORA,KALRN,LRP1B,ADCY2,PARD3,SLC1A2,PRKCA,LSAMP,RYR3,NRG3,GPC5,HPSE2,GPM6A,TSHZ2,CTNND2,SOX5,FMN2,PLCB1,NPAS3,PTPRZ1,FYN
7.084e-05	-9.56	cellular response to stimulus	biological process	GO:0051716	6307	31	18204	50	AQP4,AHCYL1,PARD3,EYA2,PITPNC1,FYN,MACF1,KALRN,NTRK2,SLC1A2,ATP1A2,MAPK10,PLCB1,SLC7A11,FMN2,DTNA,CNTN1,NRG3,PRKCA,ARHGEF4,ADCY2,CTNND2,EFEMP1,CLU,ABCA1,RYR3,SORBS1,BMPR1B,RORA,MAP3K5,DCLK2
7.242e-05	-9.53	Kinase-like_dom_sf	interpro domains	IPR011009	523	8	18521	50	NTRK2,DCLK2,MAP3K5,PRKCA,BMPR1B,KALRN,MAPK10,FYN
7.343e-05	-9.52	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	19	16828	49	CNTN1,NRCAM,NTRK2,MAP3K5,ADCY2,LRP1B,ABCA1,ATP1A2,SLC1A2,EFEMP1,CTNND2,TRPM3,ARHGEF4,NRG3,HPSE2,PTPRZ1,FMN2,SOX5,RFX4
7.385e-05	-9.51	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	9	19454	50	PLCB1,AHCYL1,MSI2,ABLIM1,SLC7A11,DTNA,MACF1,FMN2,PARD3
7.434e-05	-9.51	cell projection organization	biological process	GO:0030030	1200	12	18204	50	CTNND2,KALRN,RFX4,PARD3,CNTN1,GPM6A,FYN,ARHGEF4,PTPRZ1,BMPR1B,ABLIM1,NRCAM
7.654e-05	-9.48	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	16	16828	49	RORA,CNTN1,ABCA1,LRP1B,RYR3,HPSE2,GPM6A,MACF1,FMN2,PARD3B,SOX5,PLCB1,NEBL,NPAS3,BMPR1B,FYN
7.750e-05	-9.47	larynx	COSMIC cancer mutations	larynx	1948	16	16828	49	SOX5,FMN2,PARD3B,NEBL,NPAS3,PLCB1,FYN,BMPR1B,HPSE2,GPM6A,MACF1,ABCA1,LRP1B,RYR3,RORA,CNTN1
7.934e-05	-9.44	SH3 Domains	gene3d domains	2.30.30.40	223	6	14470	47	ARHGEF4,NEBL,KALRN,MACF1,SORBS1,FYN
7.937e-05	-9.44	prostate	COSMIC cancer mutations	prostate	13883	49	16828	49	NRG3,MSI2,NEBL,RORA,NRCAM,GLIS3,CNTN1,SLC7A11,ABCA1,SLC1A2,LSAMP,PRKCA,ARHGEF4,GPC5,CTNND2,CLU,RFX4,FMN2,PTPRZ1,FYN,DTNA,SORBS1,ADCY2,AHCYL1,GPM6A,DCLK2,SOX5,PARD3B,PLCB1,PITPNC1,HIF3A,KALRN,ATP1A2,LRP1B,NTRK2,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,TRPS1,AQP4,NPAS3,BMPR1B,EYA2,PARD3,MAP3K5,EFEMP1,RYR3
8.099e-05	-9.42	Sphingolipid signaling pathway	KEGG pathways	hsa04071	118	5	7161	28	PLCB1,MAPK10,MAP3K5,PRKCA,FYN
8.099e-05	-9.42	Sphingolipid signaling pathway	KEGG pathways	ko04071	118	5	7161	28	PLCB1,MAPK10,MAP3K5,PRKCA,FYN
8.655e-05	-9.35	oligodendrocyte differentiation	biological process	GO:0048709	85	4	18204	50	NTRK2,CLU,CNTN1,PTPRZ1
8.772e-05	-9.34	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	17	16828	49	GPC5,HPSE2,NRG3,CTNND2,GPM6A,NEBL,PLCB1,SOX5,FMN2,PTPRZ1,SLC1A2,LRP1B,ADCY2,PARD3,LSAMP,NTRK2,RYR3
8.772e-05	-9.34	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	17	16828	49	LSAMP,NTRK2,RYR3,LRP1B,PARD3,ADCY2,SLC1A2,GPM6A,CTNND2,NRG3,GPC5,HPSE2,PTPRZ1,SOX5,FMN2,NEBL,PLCB1
9.014e-05	-9.31	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	6	19454	50	DTNA,SORBS1,PARD3B,PARD3,PLCB1,NTRK2
9.037e-05	-9.31	PTPRZ1 (protein tyrosine phosphatase receptor type Z1)	protein interactions	5803	34	3	19454	50	FYN,PTPRZ1,CNTN1
9.194e-05	-9.29	cell junction organization	biological process	GO:0034330	532	8	18204	50	NRG3,FYN,NRCAM,PRKCA,PARD3,SORBS1,CTNND2,GPM6A
9.546e-05	-9.26	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	9	18094	50	BMPR1B,MAP3K5,NTRK2,MAPK10,FYN,KALRN,EFEMP1,DCLK2,PRKCA
9.574e-05	-9.25	Activation of PKC Through G Protein-Coupled Receptor	SMPDB pathways	SMP0000749	4	2	1369	6	PLCB1,PRKCA
9.782e-05	-9.23	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	17	16828	49	NEBL,PLCB1,SOX5,FMN2,PTPRZ1,GPC5,HPSE2,NRG3,CTNND2,GPM6A,SLC1A2,LRP1B,ADCY2,PARD3,NTRK2,LSAMP,RYR3
9.850e-05	-9.23	neuron projection development	biological process	GO:0031175	693	9	18204	50	GPM6A,BMPR1B,CNTN1,PARD3,NRCAM,FYN,PTPRZ1,CTNND2,KALRN
1.004e-04	-9.21	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	8	10285	33	FYN,AHCYL1,NRG3,ADCY2,ARHGEF4,NTRK2,KALRN,PRKCA
1.044e-04	-9.17	learning or memory	biological process	GO:0007611	276	6	18204	50	PLCB1,NTRK2,FYN,ATP1A2,SLC7A11,PTPRZ1
1.052e-04	-9.16	membrane raft	cellular component	GO:0045121	290	6	19108	50	SLC1A2,ADCY2,ABCA1,ATP1A2,FYN,SORBS1
1.093e-04	-9.12	membrane microdomain	cellular component	GO:0098857	292	6	19108	50	SORBS1,FYN,ATP1A2,SLC1A2,ABCA1,ADCY2
1.123e-04	-9.09	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	16	16828	49	ATP1A2,LRP1B,PARD3,SORBS1,EFEMP1,RORA,EYA2,SLC7A11,FMN2,PLCB1,NEBL,BMPR1B,NRG3,ABLIM1,TSHZ2,CTNND2
1.123e-04	-9.09	mucosal	COSMIC cancer mutations	mucosal	2009	16	16828	49	ATP1A2,LRP1B,PARD3,SORBS1,EFEMP1,RORA,EYA2,SLC7A11,FMN2,PLCB1,NEBL,BMPR1B,NRG3,ABLIM1,TSHZ2,CTNND2
1.200e-04	-9.03	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	14	18204	50	EFEMP1,KALRN,NTRK2,PRKCA,ADCY2,FYN,PTPRZ1,DCLK2,BMPR1B,MAPK10,RORA,ATP1A2,PLCB1,MAP3K5
1.245e-04	-8.99	cell junction assembly	biological process	GO:0034329	285	6	18204	50	SORBS1,PARD3,GPM6A,NRG3,NRCAM,PRKCA
1.260e-04	-8.98	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	17	16828	49	CNTN1,NRCAM,NTRK2,EFEMP1,SLC1A2,ATP1A2,LRP1B,MAP3K5,TRPM3,CTNND2,HPSE2,NRG3,ARHGEF4,PTPRZ1,SOX5,RFX4,FMN2
1.404e-04	-8.87	axon development	biological process	GO:0061564	420	7	18204	50	FYN,NRCAM,PARD3,BMPR1B,CNTN1,KALRN,PTPRZ1
1.414e-04	-8.86	phosphorus metabolic process	biological process	GO:0006793	1707	14	18204	50	PTPRZ1,DCLK2,ATP1A2,RORA,MAPK10,BMPR1B,MAP3K5,PLCB1,EFEMP1,NTRK2,KALRN,FYN,ADCY2,PRKCA
1.446e-04	-8.84	phosphorylation	biological process	GO:0016310	729	9	18204	50	EFEMP1,DCLK2,NTRK2,KALRN,MAPK10,BMPR1B,PRKCA,MAP3K5,FYN
1.481e-04	-8.82	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	4	10285	33	PLCB1,AHCYL1,ADCY2,PRKCA
1.537e-04	-8.78	SH3	prosite domains	PS50002	222	6	12186	45	KALRN,NEBL,ARHGEF4,FYN,SORBS1,MACF1
1.557e-04	-8.77	intracellular signal transduction	biological process	GO:0035556	1505	13	18204	50	ADCY2,PRKCA,ARHGEF4,NRG3,FYN,RYR3,KALRN,PLCB1,MAP3K5,MAPK10,ATP1A2,FMN2,DCLK2
1.578e-04	-8.75	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	7	18204	50	EFEMP1,NTRK2,KALRN,SORBS1,PLCB1,NRG3,FYN
1.604e-04	-8.74	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	8	14470	47	PRKCA,KALRN,NTRK2,MAP3K5,MAPK10,FYN,BMPR1B,DCLK2
1.633e-04	-8.72	seminoma	COSMIC cancer mutations	seminoma	700	9	16828	49	CNTN1,TSHZ2,TRPS1,DCLK2,MAP3K5,FYN,BMPR1B,NTRK2,PRKCA
1.644e-04	-8.71	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	10	16828	49	CNTN1,MACF1,TSHZ2,MAP3K5,TRPS1,DCLK2,BMPR1B,FYN,PRKCA,NTRK2
1.677e-04	-8.69	kinase activity	molecular function	GO:0016301	739	9	18094	50	MAP3K5,BMPR1B,PRKCA,DCLK2,KALRN,EFEMP1,FYN,MAPK10,NTRK2
1.683e-04	-8.69	DAG and IP3 signaling	REACTOME pathways	R-HSA-1489509	34	3	10285	33	ADCY2,AHCYL1,PRKCA
1.730e-04	-8.66	Ser/Thr_kinase_AS	interpro domains	IPR008271	308	6	18521	50	MAPK10,MAP3K5,DCLK2,BMPR1B,PRKCA,KALRN
1.776e-04	-8.64	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	6	19454	50	PARD3,ABLIM1,MACF1,SORBS1,DTNA,NEBL
1.783e-04	-8.63	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	4	7161	28	PLCB1,PRKCA,ADCY2,ATP1A2
1.783e-04	-8.63	Thyroid hormone synthesis	KEGG pathways	ko04918	74	4	7161	28	ADCY2,PRKCA,ATP1A2,PLCB1
1.810e-04	-8.62	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	41	16828	49	HIF3A,CNTN1,NRCAM,RORA,NTRK2,PRKCA,KALRN,LRP1B,ATP1A2,ABCA1,GPM6A,NRG3,MSI2,PITPNC1,PARD3B,SOX5,DCLK2,PLCB1,NEBL,DTNA,EYA2,RYR3,SORBS1,MAP3K5,PARD3,TSHZ2,CTNND2,TRPM3,MACF1,ARHGEF4,ABLIM1,HPSE2,GPC5,PTPRZ1,BMPR1B,FYN,FMN2,CLU,RFX4,TRPS1,NPAS3
1.838e-04	-8.60	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	41	16828	49	MAP3K5,PARD3,SORBS1,RYR3,EYA2,DTNA,NPAS3,FMN2,CLU,RFX4,TRPS1,BMPR1B,FYN,PTPRZ1,HPSE2,GPC5,ABLIM1,ARHGEF4,CTNND2,TRPM3,MACF1,TSHZ2,LRP1B,KALRN,ATP1A2,ABCA1,PRKCA,NTRK2,NRCAM,RORA,HIF3A,CNTN1,NEBL,PLCB1,PARD3B,DCLK2,SOX5,PITPNC1,NRG3,MSI2,GPM6A
1.878e-04	-8.58	Gastric acid secretion	KEGG pathways	hsa04971	75	4	7161	28	ATP1A2,ADCY2,PRKCA,PLCB1
1.878e-04	-8.58	Gastric acid secretion	KEGG pathways	ko04971	75	4	7161	28	PLCB1,ATP1A2,PRKCA,ADCY2
1.886e-04	-8.58	cellular component biogenesis	biological process	GO:0044085	2716	18	18204	50	NRCAM,ABLIM1,SORBS1,FMN2,NEBL,PRKCA,ARHGEF4,NRG3,GPM6A,TRPM3,CNTN1,PARD3,AQP4,RFX4,SLC1A2,RYR3,ABCA1,CLU
1.892e-04	-8.57	dendrite	cellular component	GO:0030425	620	8	19108	50	ADCY2,CTNND2,CLU,FYN,GPM6A,ATP1A2,NTRK2,BMPR1B
1.934e-04	-8.55	dendritic tree	cellular component	GO:0097447	622	8	19108	50	ADCY2,CTNND2,CLU,FYN,GPM6A,ATP1A2,NTRK2,BMPR1B
1.999e-04	-8.52	EGFR interacts with phospholipase C-gamma	REACTOME pathways	R-HSA-212718	36	3	10285	33	AHCYL1,ADCY2,PRKCA
1.999e-04	-8.52	PLC-gamma1 signalling	REACTOME pathways	R-HSA-167021	36	3	10285	33	PRKCA,AHCYL1,ADCY2
2.013e-04	-8.51	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	10	19454	50	DTNA,MACF1,SLC7A11,AHCYL1,PRKCA,PARD3,FYN,FMN2,KALRN,ARHGEF4
2.046e-04	-8.49	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	11	19454	50	FMN2,DCLK2,PARD3,PARD3B,ARHGEF4,ABLIM1,MAP3K5,MACF1,SORBS1,PRKCA,PITPNC1
2.059e-04	-8.49	cell development	biological process	GO:0048468	2236	16	18204	50	FYN,MSI2,PARD3,CNTN1,GPM6A,KALRN,NTRK2,CTNND2,CLU,NRCAM,BMPR1B,RORA,DCLK2,NEBL,FMN2,PTPRZ1
2.076e-04	-8.48	Neurofascin interactions	REACTOME pathways	R-HSA-447043	7	2	10285	33	NRCAM,CNTN1
2.282e-04	-8.39	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	6	16828	49	GPM6A,GPC5,LRP1B,SOX5,FMN2,ADCY2
2.294e-04	-8.38	cognition	biological process	GO:0050890	319	6	18204	50	ATP1A2,FYN,PLCB1,PTPRZ1,SLC7A11,NTRK2
2.300e-04	-8.38	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	45	16828	49	DTNA,SORBS1,ADCY2,GPC5,ARHGEF4,CTNND2,RFX4,FMN2,FYN,PTPRZ1,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,SLC1A2,ABCA1,LSAMP,PRKCA,NRG3,NEBL,EYA2,MAP3K5,PARD3,RYR3,HPSE2,ABLIM1,MACF1,TRPM3,TSHZ2,NPAS3,TRPS1,BMPR1B,HIF3A,KALRN,ATP1A2,LRP1B,NTRK2,AHCYL1,GPM6A,PLCB1,DCLK2,SOX5,PARD3B,PITPNC1
2.305e-04	-8.38	testis	COSMIC cancer mutations	testis	733	9	16828	49	PRKCA,NTRK2,BMPR1B,FYN,MAP3K5,DCLK2,TRPS1,TSHZ2,MACF1
2.328e-04	-8.37	cervix	COSMIC cancer mutations	cervix	11793	45	16828	49	PTPRZ1,FYN,RFX4,FMN2,CTNND2,ARHGEF4,GPC5,SORBS1,ADCY2,DTNA,NEBL,NRG3,LSAMP,PRKCA,ABCA1,SLC1A2,GLIS3,CNTN1,SLC7A11,RORA,NRCAM,BMPR1B,TRPS1,NPAS3,TSHZ2,MACF1,TRPM3,ABLIM1,HPSE2,RYR3,PARD3,MAP3K5,EYA2,PITPNC1,SOX5,DCLK2,PARD3B,PLCB1,GPM6A,AHCYL1,NTRK2,ATP1A2,LRP1B,KALRN,HIF3A
2.370e-04	-8.35	RHOB (ras homolog family member B)	protein interactions	388	832	9	19454	50	FMN2,PARD3,FYN,PARD3B,ABLIM1,DTNA,MACF1,PLCB1,SLC7A11
2.384e-04	-8.34	Phospholipase C Signaling Pathway	SMPDB pathways	SMP0063783	6	2	1369	6	PLCB1,PRKCA
2.443e-04	-8.32	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	4	16828	49	LRP1B,NRG3,PARD3,GPC5
2.551e-04	-8.27	acidic amino acid transport	biological process	GO:0015800	45	3	18204	50	SLC1A2,NTRK2,SLC7A11
2.586e-04	-8.26	cellular response to organic cyclic compound	biological process	GO:0071407	464	7	18204	50	ADCY2,PLCB1,ATP1A2,RORA,SLC1A2,ABCA1,RYR3
2.597e-04	-8.26	behavior	biological process	GO:0007610	619	8	18204	50	NTRK2,SLC1A2,SLC7A11,PTPRZ1,FYN,PLCB1,ATP1A2,CNTN1
2.612e-04	-8.25	SH3-like_dom_sf	interpro domains	IPR036028	212	5	18521	50	KALRN,ARHGEF4,SORBS1,FYN,NEBL
2.623e-04	-8.25	nipple	COSMIC cancer mutations	nipple	197	5	16828	49	SLC7A11,BMPR1B,FMN2,LRP1B,EFEMP1
2.623e-04	-8.25	skin-nipple-malignant_melanoma	COSMIC cancer mutations	skin-nipple-malignant_melanoma	197	5	16828	49	LRP1B,FMN2,EFEMP1,BMPR1B,SLC7A11
2.627e-04	-8.24	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	4	16828	49	HIF3A,ABCA1,PARD3B,NEBL
2.680e-04	-8.22	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	9	16828	49	NTRK2,PLCB1,NEBL,SOX5,TRPS1,LRP1B,PARD3,CTNND2,DTNA
2.764e-04	-8.19	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	18	16828	49	EYA2,NRCAM,PARD3,MAP3K5,KALRN,ATP1A2,LRP1B,ABCA1,RYR3,LSAMP,HPSE2,NRG3,CTNND2,PLCB1,NEBL,TRPS1,SOX5,PTPRZ1
2.790e-04	-8.18	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	11	16828	49	PLCB1,SORBS1,ADCY2,KALRN,LRP1B,ABCA1,EYA2,SLC7A11,CTNND2,MACF1,TSHZ2
2.802e-04	-8.18	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	8	18204	50	EFEMP1,KALRN,NTRK2,BMPR1B,SORBS1,PLCB1,FYN,NRG3
2.928e-04	-8.14	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	18	16828	49	RORA,GLIS3,ADCY2,SORBS1,MAP3K5,ABCA1,LRP1B,RYR3,ARHGEF4,CTNND2,TRPM3,MACF1,TSHZ2,NPAS3,AQP4,PARD3B,FMN2,PTPRZ1
2.928e-04	-8.14	embryonal	COSMIC cancer mutations	embryonal	2659	18	16828	49	RYR3,ABCA1,LRP1B,ADCY2,SORBS1,MAP3K5,GLIS3,RORA,PTPRZ1,PARD3B,FMN2,AQP4,NPAS3,TSHZ2,TRPM3,MACF1,CTNND2,ARHGEF4
2.952e-04	-8.13	regulation of cellular process	biological process	GO:0050794	11468	43	18204	50	NPAS3,DCLK2,SORBS1,BMPR1B,GLIS3,CLU,ABCA1,DTNA,CNTN1,GPM6A,TSHZ2,TRPS1,ADCY2,HIF3A,FMN2,ATP1A2,KALRN,PARD3,AHCYL1,EYA2,PITPNC1,FYN,MSI2,GPC5,HPSE2,RORA,MAP3K5,CTNND2,EFEMP1,SOX5,RYR3,NRG3,PRKCA,ARHGEF4,PTPRZ1,SLC7A11,MAPK10,PLCB1,NRCAM,MACF1,NTRK2,SLC1A2,RFX4
3.046e-04	-8.10	Insulin secretion	KEGG pathways	hsa04911	85	4	7161	28	PLCB1,PRKCA,ADCY2,ATP1A2
3.095e-04	-8.08	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	24	16828	49	NRCAM,SLC7A11,HIF3A,CNTN1,PARD3,SORBS1,ADCY2,LRP1B,KALRN,RYR3,NTRK2,HPSE2,NRG3,CTNND2,TRPM3,MACF1,GPM6A,PLCB1,PARD3B,FMN2,RFX4,SOX5,TRPS1,PTPRZ1
3.162e-04	-8.06	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	4	19454	50	ABLIM1,MACF1,DTNA,PARD3
3.212e-04	-8.04	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	16	16828	49	PRKCA,NTRK2,KALRN,ATP1A2,LRP1B,ADCY2,MAP3K5,DTNA,PTPRZ1,FYN,BMPR1B,TRPS1,DCLK2,SOX5,PARD3B,TSHZ2
3.231e-04	-8.04	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	3	19454	50	NTRK2,FYN,SORBS1
3.258e-04	-8.03	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	8	12186	45	MAP3K5,KALRN,DCLK2,FYN,BMPR1B,NTRK2,MAPK10,PRKCA
3.270e-04	-8.03	regulation of cell differentiation	biological process	GO:0045595	1622	13	18204	50	EFEMP1,MACF1,NTRK2,SOX5,ABCA1,PRKCA,TRPS1,PTPRZ1,BMPR1B,RORA,MAP3K5,PLCB1,NRCAM
3.281e-04	-8.02	establishment of centrosome localization	biological process	GO:0051660	10	2	18204	50	PARD3B,PARD3
3.283e-04	-8.02	glial cell differentiation	biological process	GO:0010001	219	5	18204	50	NTRK2,CNTN1,CLU,PTPRZ1,PARD3
3.331e-04	-8.01	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	6	16828	49	PTPRZ1,SORBS1,ADCY2,PARD3B,MAP3K5,LRP1B
3.423e-04	-7.98	animal organ development	biological process	GO:0048513	2846	18	18204	50	DCLK2,NEBL,SLC7A11,NRCAM,PLCB1,RORA,ABLIM1,BMPR1B,ATP1A2,SLC1A2,SOX5,NTRK2,EFEMP1,NRG3,FYN,GPM6A,CNTN1,RFX4
3.508e-04	-7.96	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	2	19454	50	ADCY2,PRKCA
3.582e-04	-7.93	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	9	16828	49	NTRK2,PRKCA,BMPR1B,FYN,ADCY2,MAP3K5,DCLK2,SOX5,CTNND2
3.582e-04	-7.93	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	9	16828	49	ADCY2,MAP3K5,DCLK2,SOX5,NTRK2,PRKCA,BMPR1B,FYN,CTNND2
3.642e-04	-7.92	axon guidance	biological process	GO:0007411	224	5	18204	50	CNTN1,BMPR1B,KALRN,FYN,NRCAM
3.642e-04	-7.92	neuron projection guidance	biological process	GO:0097485	224	5	18204	50	CNTN1,BMPR1B,NRCAM,KALRN,FYN
3.647e-04	-7.92	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	27	16828	49	CTNND2,TSHZ2,ARHGEF4,ABLIM1,BMPR1B,FYN,PTPRZ1,NPAS3,CLU,TRPS1,MAP3K5,ADCY2,PARD3,AHCYL1,MSI2,PITPNC1,PLCB1,DCLK2,SOX5,HIF3A,CNTN1,RORA,NTRK2,LSAMP,PRKCA,KALRN,LRP1B
3.647e-04	-7.92	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	27	16828	49	HIF3A,CNTN1,RORA,LSAMP,PRKCA,NTRK2,LRP1B,KALRN,AHCYL1,MSI2,PITPNC1,PLCB1,DCLK2,SOX5,PARD3,MAP3K5,ADCY2,CTNND2,TSHZ2,ABLIM1,ARHGEF4,BMPR1B,FYN,PTPRZ1,NPAS3,CLU,TRPS1
3.669e-04	-7.91	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	10	19454	50	MACF1,SORBS1,MAP3K5,PITPNC1,PARD3B,PARD3,DCLK2,FMN2,ABLIM1,ARHGEF4
3.702e-04	-7.90	EZR (ezrin)	protein interactions	7430	526	7	19454	50	SORBS1,DTNA,MACF1,NEBL,MAPK10,PRKCA,ABLIM1
3.795e-04	-7.88	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	6	16828	49	ADCY2,SORBS1,MAP3K5,PARD3B,LRP1B,PTPRZ1
3.815e-04	-7.87	PLCB1 (phospholipase C beta 1)	protein interactions	23236	55	3	19454	50	PLCB1,PRKCA,PARD3
3.847e-04	-7.86	actin cytoskeleton	cellular component	GO:0015629	520	7	19108	50	NEBL,MACF1,KALRN,FMN2,SORBS1,ABLIM1,FYN
4.003e-04	-7.82	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	50	SLC1A2,SLC7A11
4.026e-04	-7.82	leg	COSMIC cancer mutations	leg	969	10	16828	49	TSHZ2,CNTN1,HIF3A,SLC7A11,NRG3,PTPRZ1,LRP1B,FMN2,PLCB1,NEBL
4.051e-04	-7.81	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	2	18094	50	SLC1A2,SLC7A11
4.052e-04	-7.81	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	21	16828	49	FMN2,PARD3B,DCLK2,PLCB1,NPAS3,PTPRZ1,FYN,ARHGEF4,HPSE2,GPC5,CTNND2,MACF1,TRPM3,PARD3,ADCY2,MAP3K5,ATP1A2,ABCA1,LRP1B,RYR3,CNTN1
4.126e-04	-7.79	GnRH signaling pathway	KEGG pathways	ko04912	92	4	7161	28	MAPK10,PLCB1,PRKCA,ADCY2
4.126e-04	-7.79	GnRH signaling pathway	KEGG pathways	hsa04912	92	4	7161	28	PRKCA,ADCY2,MAPK10,PLCB1
4.131e-04	-7.79	Integration of energy metabolism	REACTOME pathways	R-HSA-163685	111	4	10285	33	AHCYL1,ADCY2,PLCB1,PRKCA
4.182e-04	-7.78	glial cell development	biological process	GO:0021782	128	4	18204	50	PARD3,CNTN1,CLU,NTRK2
4.182e-04	-7.78	myelination	biological process	GO:0042552	128	4	18204	50	NTRK2,CLU,CNTN1,PARD3
4.219e-04	-7.77	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	7	12186	45	MAP3K5,KALRN,DCLK2,BMPR1B,FYN,NTRK2,PRKCA
4.282e-04	-7.76	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	49	16828	49	EYA2,RYR3,PARD3,MAP3K5,EFEMP1,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,BMPR1B,TRPS1,AQP4,NPAS3,HIF3A,NTRK2,LRP1B,KALRN,ATP1A2,GPM6A,AHCYL1,PITPNC1,PARD3B,DCLK2,SOX5,PLCB1,DTNA,SORBS1,ADCY2,CTNND2,ARHGEF4,GPC5,PTPRZ1,FYN,FMN2,CLU,RFX4,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,PRKCA,LSAMP,ABCA1,SLC1A2,MSI2,NRG3,NEBL
4.421e-04	-7.72	Acetylcholine regulates insulin secretion	REACTOME pathways	R-HSA-399997	10	2	10285	33	PRKCA,PLCB1
4.434e-04	-7.72	axon ensheathment	biological process	GO:0008366	130	4	18204	50	CLU,CNTN1,PARD3,NTRK2
4.434e-04	-7.72	ensheathment of neurons	biological process	GO:0007272	130	4	18204	50	CLU,CNTN1,PARD3,NTRK2
4.529e-04	-7.70	Ig_sub2	interpro domains	IPR003598	239	5	18521	50	NRCAM,LSAMP,CNTN1,NTRK2,KALRN
4.661e-04	-7.67	cell surface	cellular component	GO:0009986	896	9	19108	50	ATP1A2,GPC5,SLC1A2,AQP4,SLC7A11,ABCA1,NRCAM,MAP3K5,CLU
4.663e-04	-7.67	Pancreatic secretion	KEGG pathways	ko04972	95	4	7161	28	PLCB1,ATP1A2,PRKCA,ADCY2
4.663e-04	-7.67	Pancreatic secretion	KEGG pathways	hsa04972	95	4	7161	28	PLCB1,ATP1A2,ADCY2,PRKCA
4.721e-04	-7.66	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	42	16828	49	MACF1,TRPM3,CTNND2,TSHZ2,GPC5,HPSE2,ABLIM1,ARHGEF4,FYN,PTPRZ1,AQP4,NPAS3,RFX4,CLU,TRPS1,FMN2,DTNA,EYA2,RYR3,EFEMP1,MAP3K5,ADCY2,PARD3,SORBS1,GPM6A,AHCYL1,NRG3,NEBL,PLCB1,SOX5,CNTN1,SLC7A11,RORA,NRCAM,PRKCA,LSAMP,NTRK2,SLC1A2,LRP1B,ATP1A2,ABCA1,KALRN
4.742e-04	-7.65	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	10	18204	50	ABCA1,RYR3,SLC1A2,RORA,AHCYL1,SORBS1,PLCB1,ADCY2,FYN,MAP3K5
4.795e-04	-7.64	sulfur amino acid transport	biological process	GO:0000101	12	2	18204	50	SLC1A2,SLC7A11
4.852e-04	-7.63	Circadian entrainment	KEGG pathways	ko04713	96	4	7161	28	PLCB1,RYR3,ADCY2,PRKCA
4.852e-04	-7.63	Circadian entrainment	KEGG pathways	hsa04713	96	4	7161	28	PRKCA,ADCY2,RYR3,PLCB1
4.882e-04	-7.62	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	7	16828	49	FYN,BMPR1B,NTRK2,PRKCA,DCLK2,MAP3K5,MACF1
4.894e-04	-7.62	fn3	pfam domains	PF00041	136	4	17795	48	CNTN1,NRCAM,PTPRZ1,KALRN
4.899e-04	-7.62	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	13	18204	50	PTPRZ1,ATP1A2,BMPR1B,RORA,PLCB1,MACF1,CLU,NTRK2,SOX5,ABCA1,PARD3,FYN,PRKCA
4.934e-04	-7.61	side of membrane	cellular component	GO:0098552	715	8	19108	50	NRCAM,MAP3K5,ABCA1,AQP4,LSAMP,GPC5,DTNA,CNTN1
4.992e-04	-7.60	Axon guidance	KEGG pathways	hsa04360	174	5	7161	28	BMPR1B,PARD3,FYN,PRKCA,ABLIM1
4.992e-04	-7.60	Axon guidance	KEGG pathways	ko04360	174	5	7161	28	PARD3,BMPR1B,ABLIM1,PRKCA,FYN
5.048e-04	-7.59	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	4	7161	28	PRKCA,ADCY2,MAPK10,PLCB1
5.048e-04	-7.59	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	4	7161	28	ADCY2,PRKCA,PLCB1,MAPK10
5.139e-04	-7.57	visual behavior	biological process	GO:0007632	57	3	18204	50	SLC1A2,ATP1A2,SLC7A11
5.164e-04	-7.57	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	8	16828	49	MAP3K5,DCLK2,TRPS1,PRKCA,NTRK2,BMPR1B,FYN,TSHZ2
5.164e-04	-7.57	sarcolemma	cellular component	GO:0042383	142	4	19108	50	DTNA,RYR3,ATP1A2,AQP4
5.189e-04	-7.56	non_seminoma	COSMIC cancer mutations	non_seminoma	492	7	16828	49	MACF1,PRKCA,NTRK2,FYN,BMPR1B,DCLK2,MAP3K5
5.317e-04	-7.54	lower_third	COSMIC cancer mutations	lower_third	7961	35	16828	49	PARD3B,DCLK2,SOX5,PLCB1,NEBL,NRG3,KALRN,LRP1B,ATP1A2,ABCA1,PRKCA,NTRK2,RORA,SLC7A11,CNTN1,FMN2,TRPS1,NPAS3,AQP4,PTPRZ1,FYN,ARHGEF4,HPSE2,GPC5,TSHZ2,CTNND2,TRPM3,MACF1,MAP3K5,SORBS1,ADCY2,PARD3,EFEMP1,RYR3,EYA2
5.362e-04	-7.53	DSCR9 (Down syndrome critical region 9)	protein interactions	257203	146	4	19454	50	EFEMP1,KALRN,CLU,MACF1
5.563e-04	-7.49	membrane	cellular component	GO:0016020	9220	36	19108	50	GPC5,CTNND2,NRG3,AHCYL1,FYN,NTRK2,ARHGEF4,HIF3A,GPM6A,HPSE2,ABCA1,SLC7A11,PTPRZ1,PRKCA,MAPK10,ATP1A2,KALRN,MAP3K5,NRCAM,PARD3,BMPR1B,RYR3,LSAMP,AQP4,ADCY2,LRP1B,MACF1,PARD3B,TRPM3,PLCB1,FMN2,SLC1A2,CNTN1,SORBS1,DTNA,CLU
5.566e-04	-7.49	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	42	16828	49	DTNA,EYA2,RYR3,SORBS1,PARD3,MAP3K5,ADCY2,EFEMP1,TSHZ2,TRPM3,MACF1,CTNND2,ARHGEF4,GPC5,HPSE2,PTPRZ1,FYN,BMPR1B,TRPS1,CLU,FMN2,NPAS3,GLIS3,CNTN1,RORA,NRCAM,NTRK2,LSAMP,PRKCA,LRP1B,ABCA1,ATP1A2,KALRN,SLC1A2,NRG3,MSI2,AHCYL1,DCLK2,SOX5,PARD3B,PLCB1,NEBL
5.583e-04	-7.49	regulation of synapse organization	biological process	GO:0050807	246	5	18204	50	GPM6A,SLC7A11,NRCAM,FYN,NTRK2
5.643e-04	-7.48	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	3	10285	33	NRG3,PRKCA,FYN
5.776e-04	-7.46	PLXNA4 (plexin A4)	protein interactions	91584	14	2	19454	50	CLU,GPM6A
5.884e-04	-7.44	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	4	7161	28	PLCB1,MAPK10,PRKCA,ADCY2
5.884e-04	-7.44	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	4	7161	28	PLCB1,MAPK10,ADCY2,PRKCA
5.976e-04	-7.42	transmission of nerve impulse	biological process	GO:0019226	60	3	18204	50	NRCAM,NTRK2,ATP1A2
6.007e-04	-7.42	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	12	16828	49	LRP1B,PARD3,MAP3K5,ADCY2,PLCB1,PRKCA,RYR3,NRG3,GPC5,HPSE2,TSHZ2,TRPM3
6.044e-04	-7.41	tibia	COSMIC cancer mutations	tibia	836	9	16828	49	ARHGEF4,ABLIM1,GPM6A,MACF1,TRPM3,CTNND2,LRP1B,PLCB1,LSAMP
6.057e-04	-7.41	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	13	16828	49	GPC5,TRPM3,MACF1,NPAS3,NEBL,SOX5,DCLK2,PTPRZ1,HIF3A,ABCA1,LRP1B,PARD3,PRKCA
6.116e-04	-7.40	calcium ion transport	biological process	GO:0006816	251	5	18204	50	PLCB1,RYR3,FYN,TRPM3,GPM6A
6.126e-04	-7.40	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	8	16828	49	TSHZ2,NTRK2,PRKCA,BMPR1B,FYN,MAP3K5,LRP1B,DCLK2
6.138e-04	-7.40	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	30	16828	49	SOX5,PARD3B,PLCB1,NEBL,NRG3,ABCA1,KALRN,LRP1B,PRKCA,NTRK2,RORA,CNTN1,SLC7A11,TRPS1,FMN2,AQP4,NPAS3,PTPRZ1,FYN,GPC5,TSHZ2,MACF1,TRPM3,CTNND2,SORBS1,ADCY2,PARD3,EFEMP1,RYR3,EYA2
6.187e-04	-7.39	neuron migration	biological process	GO:0001764	142	4	18204	50	NRCAM,FYN,NTRK2,GPM6A
6.227e-04	-7.38	regulation of synapse structure or activity	biological process	GO:0050803	252	5	18204	50	NTRK2,FYN,NRCAM,SLC7A11,GPM6A
6.372e-04	-7.36	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	8	16828	49	TSHZ2,MAP3K5,DCLK2,LRP1B,BMPR1B,FYN,PRKCA,NTRK2
6.450e-04	-7.35	FYN (FYN proto-oncogene, Src family tyrosine kinase)	protein interactions	2534	414	6	19454	50	FYN,CTNND2,PTPRZ1,CNTN1,KALRN,NTRK2
6.542e-04	-7.33	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	47	16828	49	GLIS3,CNTN1,SLC7A11,RORA,NRCAM,PRKCA,LSAMP,ABCA1,SLC1A2,MSI2,NRG3,NEBL,DTNA,ADCY2,SORBS1,CTNND2,ARHGEF4,GPC5,PTPRZ1,FYN,RFX4,CLU,FMN2,HIF3A,NTRK2,LRP1B,KALRN,ATP1A2,GPM6A,PITPNC1,DCLK2,SOX5,PARD3B,PLCB1,EYA2,RYR3,MAP3K5,PARD3,EFEMP1,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,BMPR1B,TRPS1,NPAS3
6.667e-04	-7.31	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	50	SLC7A11,SLC1A2
6.816e-04	-7.29	PARD6A (par-6 family cell polarity regulator alpha)	protein interactions	50855	67	3	19454	50	PARD3,PRKCA,PLCB1
6.850e-04	-7.29	scalp	COSMIC cancer mutations	scalp	2110	15	16828	49	RORA,EYA2,NRCAM,CNTN1,ATP1A2,SORBS1,LSAMP,GPC5,MACF1,NEBL,PLCB1,SOX5,TRPS1,FMN2,PTPRZ1
6.963e-04	-7.27	pancreas-carcinoma-adenocarcinoma	COSMIC cancer mutations	pancreas-carcinoma-adenocarcinoma	517	7	16828	49	ARHGEF4,GPC5,HPSE2,MACF1,DCLK2,LRP1B,NEBL
6.998e-04	-7.26	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	9	19454	50	MACF1,SORBS1,MAP3K5,PITPNC1,DCLK2,PARD3B,PARD3,ARHGEF4,ABLIM1
7.006e-04	-7.26	cell surface receptor signaling pathway	biological process	GO:0007166	1992	14	18204	50	PLCB1,SORBS1,BMPR1B,MAPK10,NTRK2,KALRN,ABCA1,CTNND2,EFEMP1,MACF1,NRG3,FYN,EYA2,CNTN1
7.080e-04	-7.25	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	4	16828	49	PARD3,LRP1B,NRG3,GPC5
7.156e-04	-7.24	positive regulation of cell differentiation	biological process	GO:0045597	906	9	18204	50	BMPR1B,MAP3K5,NRCAM,PRKCA,PLCB1,PTPRZ1,MACF1,SOX5,NTRK2
7.296e-04	-7.22	response to organic substance	biological process	GO:0010033	2498	16	18204	50	PLCB1,MAP3K5,RORA,SORBS1,ATP1A2,SLC7A11,PRKCA,ADCY2,FYN,AQP4,AHCYL1,ABCA1,RYR3,SLC1A2,NTRK2,CLU
7.297e-04	-7.22	transferase activity, transferring phosphorus-containing groups	molecular function	GO:0016772	903	9	18094	50	NTRK2,MAPK10,BMPR1B,MAP3K5,DCLK2,PRKCA,FYN,EFEMP1,KALRN
7.415e-04	-7.21	temporoparietal	COSMIC cancer mutations	temporoparietal	61	3	16828	49	TSHZ2,RYR3,PARD3
7.428e-04	-7.21	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	17	16828	49	TRPM3,MACF1,ARHGEF4,NRG3,AHCYL1,GPC5,PTPRZ1,FYN,FMN2,TRPS1,EYA2,RORA,ADCY2,PARD3,LRP1B,KALRN,ABCA1
7.430e-04	-7.20	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	3	10285	33	ATP1A2,RYR3,AHCYL1
7.481e-04	-7.20	TRAF2 (TNF receptor associated factor 2)	protein interactions	7186	592	7	19454	50	SOX5,MAP3K5,SLC7A11,TSHZ2,NEBL,ABLIM1,EFEMP1
7.496e-04	-7.20	main axon	cellular component	GO:0044304	68	3	19108	50	SLC1A2,NRCAM,PARD3
7.502e-04	-7.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	5	16828	49	HPSE2,NPAS3,GPC5,ADCY2,NRG3
7.502e-04	-7.20	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	5	16828	49	NRG3,ADCY2,GPC5,NPAS3,HPSE2
7.738e-04	-7.16	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	ko04961	47	3	7161	28	PRKCA,ATP1A2,PLCB1
7.738e-04	-7.16	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	hsa04961	47	3	7161	28	PLCB1,ATP1A2,PRKCA
7.764e-04	-7.16	localization	biological process	GO:0051179	4474	23	18204	50	PARD3,AHCYL1,AQP4,PITPNC1,EYA2,FYN,MACF1,NTRK2,KALRN,SLC1A2,ATP1A2,NRCAM,PLCB1,SLC7A11,FMN2,PARD3B,GPM6A,TRPM3,CLU,ABCA1,RYR3,LRP1B,DCLK2
7.901e-04	-7.14	establishment of localization	biological process	GO:0051234	3887	21	18204	50	GPM6A,PITPNC1,TRPM3,EYA2,PARD3,AHCYL1,AQP4,FYN,MACF1,CLU,SLC1A2,RYR3,ABCA1,NTRK2,KALRN,LRP1B,ATP1A2,PLCB1,SLC7A11,FMN2,PARD3B
8.059e-04	-7.12	response to stimulus	biological process	GO:0050896	7803	33	18204	50	AQP4,PARD3,AHCYL1,EYA2,PITPNC1,FYN,MACF1,KALRN,NTRK2,SLC1A2,ATP1A2,MAPK10,PLCB1,SLC7A11,FMN2,DTNA,CNTN1,GPM6A,NRG3,PRKCA,ARHGEF4,ADCY2,CTNND2,CLU,EFEMP1,SOX5,ABCA1,RYR3,SORBS1,BMPR1B,RORA,MAP3K5,DCLK2
8.074e-04	-7.12	MAPK4 (mitogen-activated protein kinase 4)	protein interactions	5596	71	3	19454	50	SLC7A11,AHCYL1,MAP3K5
8.590e-04	-7.06	TNNT2 (troponin T2, cardiac type)	protein interactions	7139	17	2	19454	50	MAP3K5,PRKCA
8.590e-04	-7.06	CNTN2 (contactin 2)	protein interactions	6900	17	2	19454	50	CNTN1,NRCAM
8.657e-04	-7.05	asymmetric cell division	biological process	GO:0008356	16	2	18204	50	PARD3,SOX5
8.691e-04	-7.05	Cholinergic synapse	KEGG pathways	hsa04725	112	4	7161	28	ADCY2,FYN,PRKCA,PLCB1
8.816e-04	-7.03	PROTEIN_KINASE_ST	prosite domains	PS00108	308	6	12186	45	MAP3K5,KALRN,DCLK2,BMPR1B,MAPK10,PRKCA
8.869e-04	-7.03	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	2	10285	33	ABLIM1,FYN
8.890e-04	-7.03	cellular response to endogenous stimulus	biological process	GO:0071495	1135	10	18204	50	RYR3,SLC1A2,NTRK2,SOX5,BMPR1B,ATP1A2,SORBS1,AHCYL1,PLCB1,FYN
9.223e-04	-6.99	gliogenesis	biological process	GO:0042063	275	5	18204	50	PTPRZ1,PARD3,CNTN1,CLU,NTRK2
9.287e-04	-6.98	Glutamatergic synapse	KEGG pathways	hsa04724	114	4	7161	28	PRKCA,ADCY2,SLC1A2,PLCB1
9.287e-04	-6.98	Glutamatergic synapse	KEGG pathways	ko04724	114	4	7161	28	PLCB1,SLC1A2,ADCY2,PRKCA
9.308e-04	-6.98	nef (Nef)	protein interactions	156110	802	8	19454	50	FYN,ADCY2,GPM6A,MAP3K5,SORBS1,BMPR1B,ABCA1,PRKCA
9.311e-04	-6.98	cell differentiation	biological process	GO:0030154	3645	20	18204	50	FMN2,NEBL,DCLK2,SLC7A11,PTPRZ1,NRCAM,PLCB1,RORA,BMPR1B,SOX5,NTRK2,KALRN,CTNND2,CLU,MSI2,FYN,PARD3,GPM6A,EYA2,CNTN1
9.412e-04	-6.97	cellular developmental process	biological process	GO:0048869	3648	20	18204	50	SOX5,NTRK2,KALRN,CLU,CTNND2,MSI2,FYN,GPM6A,CNTN1,EYA2,PARD3,FMN2,NEBL,DCLK2,SLC7A11,PTPRZ1,NRCAM,PLCB1,RORA,BMPR1B
9.444e-04	-6.96	cell adhesion	biological process	GO:0007155	942	9	18204	50	CTNND2,SLC7A11,PARD3B,CNTN1,PARD3,SORBS1,PRKCA,NRCAM,LSAMP
9.490e-04	-6.96	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	7	16828	49	MAP3K5,FMN2,DCLK2,PRKCA,NTRK2,BMPR1B,FYN
9.592e-04	-6.95	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	7	16828	49	NTRK2,PRKCA,FYN,BMPR1B,DCLK2,FMN2,MAP3K5
9.775e-04	-6.93	cellular response to nitrogen compound	biological process	GO:1901699	580	7	18204	50	SLC1A2,RYR3,MAP3K5,FYN,PLCB1,SORBS1,AHCYL1
9.794e-04	-6.93	reverse cholesterol transport	biological process	GO:0043691	17	2	18204	50	CLU,ABCA1
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	GPM6A,CNTN1,LSAMP
1.032e-03	-6.88	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	48	16828	49	MAP3K5,PARD3,EFEMP1,RYR3,EYA2,TRPS1,AQP4,NPAS3,BMPR1B,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,ATP1A2,KALRN,LRP1B,NTRK2,HIF3A,DCLK2,SOX5,PARD3B,PLCB1,PITPNC1,AHCYL1,GPM6A,ADCY2,SORBS1,DTNA,CLU,FMN2,PTPRZ1,FYN,ARHGEF4,GPC5,CTNND2,ABCA1,SLC1A2,PRKCA,LSAMP,RORA,NRCAM,GLIS3,CNTN1,SLC7A11,NEBL,MSI2,NRG3
1.032e-03	-6.88	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	48	16828	49	RYR3,PARD3,MAP3K5,EFEMP1,EYA2,BMPR1B,TRPS1,AQP4,NPAS3,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,NTRK2,LRP1B,KALRN,ATP1A2,HIF3A,PITPNC1,PARD3B,SOX5,DCLK2,PLCB1,GPM6A,AHCYL1,ADCY2,SORBS1,DTNA,PTPRZ1,FYN,FMN2,CLU,CTNND2,ARHGEF4,GPC5,LSAMP,PRKCA,ABCA1,SLC1A2,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,NEBL,NRG3,MSI2
1.061e-03	-6.85	Nedd4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	25489	78	3	19454	50	NTRK2,BMPR1B,FYN
1.066e-03	-6.84	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	7	16828	49	CTNND2,ADCY2,LRP1B,TRPS1,PLCB1,RYR3,NTRK2
1.077e-03	-6.83	TNR (tenascin R)	protein interactions	7143	19	2	19454	50	CNTN1,PTPRZ1
1.089e-03	-6.82	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	7	16828	49	PLCB1,TRPS1,LRP1B,ADCY2,NTRK2,RYR3,CTNND2
1.113e-03	-6.80	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	2	18094	50	PITPNC1,ABCA1
1.113e-03	-6.80	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	50	SLC7A11,SLC1A2
1.113e-03	-6.80	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	11	16828	49	PRKCA,SORBS1,KALRN,LRP1B,ATP1A2,PARD3B,TRPS1,NPAS3,MACF1,TRPM3,ARHGEF4
1.114e-03	-6.80	protein serine/threonine kinase activity	molecular function	GO:0004674	428	6	18094	50	PRKCA,DCLK2,KALRN,MAPK10,MAP3K5,BMPR1B
1.123e-03	-6.79	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	7	16828	49	FYN,RYR3,NTRK2,PRKCA,MAP3K5,LRP1B,NRCAM
1.124e-03	-6.79	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	4	19454	50	FYN,NTRK2,NRG3,KALRN
1.134e-03	-6.78	spleen	COSMIC cancer mutations	spleen	408	6	16828	49	PTPRZ1,PARD3B,SORBS1,ADCY2,MAP3K5,LRP1B
1.165e-03	-6.76	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	6	19454	50	SLC7A11,PLCB1,AHCYL1,CNTN1,FYN,PARD3B
1.165e-03	-6.76	Regulation of KIT signaling	REACTOME pathways	R-HSA-1433559	16	2	10285	33	FYN,PRKCA
1.165e-03	-6.76	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	49	16828	49	SORBS1,ADCY2,DTNA,RFX4,CLU,FMN2,PTPRZ1,FYN,ARHGEF4,GPC5,CTNND2,ABCA1,SLC1A2,LSAMP,PRKCA,RORA,NRCAM,GLIS3,CNTN1,SLC7A11,NEBL,NRG3,MSI2,MAP3K5,PARD3,EFEMP1,RYR3,EYA2,TRPS1,NPAS3,AQP4,BMPR1B,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,LRP1B,KALRN,ATP1A2,NTRK2,HIF3A,SOX5,DCLK2,PARD3B,PLCB1,PITPNC1,AHCYL1,GPM6A
1.183e-03	-6.74	PAS	pfam domains	PF00989	19	2	17795	48	NPAS3,HIF3A
1.186e-03	-6.74	PAS_fold	interpro domains	IPR013767	19	2	18521	50	HIF3A,NPAS3
1.209e-03	-6.72	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	42	16828	49	NRG3,MSI2,AHCYL1,DCLK2,SOX5,PARD3B,PLCB1,NEBL,RORA,NRCAM,GLIS3,CNTN1,ABCA1,LRP1B,ATP1A2,KALRN,SLC1A2,LSAMP,NTRK2,PRKCA,ARHGEF4,GPC5,HPSE2,TSHZ2,MACF1,TRPM3,CTNND2,TRPS1,CLU,FMN2,NPAS3,PTPRZ1,FYN,BMPR1B,EYA2,DTNA,SORBS1,ADCY2,MAP3K5,PARD3,EFEMP1,RYR3
1.219e-03	-6.71	large_intestine-rectum	COSMIC cancer mutations	large_intestine-rectum	569	7	16828	49	CNTN1,FYN,ABCA1,TRPS1,FMN2,ADCY2,MAP3K5
1.222e-03	-6.71	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	9	16828	49	LRP1B,ABCA1,KALRN,ADCY2,SORBS1,PLCB1,MACF1,CTNND2,EYA2
1.223e-03	-6.71	Succinate Signalling During Inflammation	SMPDB pathways	SMP0084634	13	2	1369	6	PLCB1,PRKCA
1.227e-03	-6.70	cartilage condensation	biological process	GO:0001502	19	2	18204	50	BMPR1B,SOX5
1.235e-03	-6.70	response to endogenous stimulus	biological process	GO:0009719	1402	11	18204	50	BMPR1B,ATP1A2,SORBS1,PLCB1,ABCA1,RYR3,SLC1A2,SOX5,NTRK2,AHCYL1,FYN
1.265e-03	-6.67	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	10	16828	49	CTNND2,RORA,NRCAM,PRKCA,NTRK2,RYR3,FYN,LRP1B,ABCA1,MAP3K5
1.268e-03	-6.67	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	12	16828	49	PLCB1,ADCY2,PARD3,MAP3K5,LRP1B,RYR3,PRKCA,HPSE2,GPC5,NRG3,TRPM3,TSHZ2
1.276e-03	-6.66	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	6	10285	33	ADCY2,AHCYL1,FYN,NRG3,PRKCA,NTRK2
1.276e-03	-6.66	ZYX (zyxin)	protein interactions	7791	316	5	19454	50	ABLIM1,NEBL,AHCYL1,SORBS1,MACF1
1.283e-03	-6.66	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	50	SLC7A11,NTRK2,SLC1A2
1.284e-03	-6.66	arm	COSMIC cancer mutations	arm	1331	11	16828	49	SORBS1,KALRN,ATP1A2,LRP1B,PRKCA,ARHGEF4,MACF1,TRPM3,PARD3B,TRPS1,NPAS3
1.317e-03	-6.63	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	45	16828	49	HIF3A,NTRK2,ATP1A2,KALRN,LRP1B,GPM6A,PITPNC1,SOX5,PARD3B,PLCB1,EYA2,RYR3,MAP3K5,PARD3,EFEMP1,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,BMPR1B,TRPS1,NPAS3,AQP4,GLIS3,CNTN1,SLC7A11,RORA,NRCAM,LSAMP,PRKCA,ABCA1,SLC1A2,NRG3,NEBL,SORBS1,ADCY2,CTNND2,ARHGEF4,GPC5,PTPRZ1,FYN,RFX4,CLU,FMN2
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	MACF1,SORBS1
1.335e-03	-6.62	parotid	COSMIC cancer mutations	parotid	578	7	16828	49	PRKCA,NTRK2,RYR3,FYN,LRP1B,MAP3K5,NRCAM
1.345e-03	-6.61	biological regulation	biological process	GO:0065007	12501	44	18204	50	MSI2,FYN,AHCYL1,PARD3,AQP4,RFX4,PITPNC1,EYA2,NTRK2,KALRN,SLC1A2,MACF1,NRCAM,PLCB1,ATP1A2,MAPK10,FMN2,SLC7A11,HIF3A,PTPRZ1,NRG3,TSHZ2,ADCY2,TRPS1,ARHGEF4,PRKCA,DTNA,GPM6A,CNTN1,SOX5,ABCA1,RYR3,CTNND2,CLU,EFEMP1,GLIS3,MAP3K5,SORBS1,RORA,HPSE2,BMPR1B,DCLK2,NPAS3,GPC5
1.345e-03	-6.61	SH3	smart domains	SM00326	202	5	9717	40	FYN,ARHGEF4,KALRN,NEBL,SORBS1
1.361e-03	-6.60	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	50	BMPR1B,SOX5
1.365e-03	-6.60	perinuclear endoplasmic reticulum	cellular component	GO:0097038	21	2	19108	50	CLU,FYN
1.375e-03	-6.59	central nervous system neuron differentiation	biological process	GO:0021953	176	4	18204	50	RORA,BMPR1B,NTRK2,DCLK2
1.387e-03	-6.58	cytoskeletal protein binding	molecular function	GO:0008092	989	9	18094	50	CLU,NRCAM,SORBS1,FYN,MACF1,DCLK2,NEBL,FMN2,ABLIM1
1.400e-03	-6.57	postsynaptic density	cellular component	GO:0014069	317	5	19108	50	KALRN,NTRK2,CTNND2,FYN,NRCAM
1.408e-03	-6.57	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	10	16828	49	CTNND2,RORA,NRCAM,NTRK2,PRKCA,RYR3,FYN,ABCA1,LRP1B,MAP3K5
1.427e-03	-6.55	somatodendritic compartment	cellular component	GO:0036477	842	8	19108	50	CTNND2,ADCY2,FYN,CLU,ATP1A2,NTRK2,GPM6A,BMPR1B
1.429e-03	-6.55	axon	cellular component	GO:0030424	650	7	19108	50	SLC1A2,GPM6A,NTRK2,PARD3,DTNA,CNTN1,NRCAM
1.431e-03	-6.55	regulation of amide metabolic process	biological process	GO:0034248	81	3	18204	50	SLC7A11,CLU,NTRK2
1.439e-03	-6.54	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	22	16828	49	HIF3A,SLC7A11,GLIS3,ABCA1,LRP1B,ATP1A2,LSAMP,PLCB1,SOX5,DTNA,PARD3,ADCY2,RYR3,GPC5,ARHGEF4,CTNND2,TRPM3,MACF1,TSHZ2,AQP4,TRPS1,PTPRZ1
1.439e-03	-6.54	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	14	16828	49	GPC5,NRG3,MSI2,ABLIM1,FYN,BMPR1B,CNTN1,RORA,EYA2,NRCAM,NTRK2,PRKCA,ABCA1,MAP3K5
1.439e-03	-6.54	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	14	16828	49	FYN,BMPR1B,GPC5,MSI2,NRG3,ABLIM1,ABCA1,MAP3K5,NTRK2,PRKCA,RORA,NRCAM,EYA2,CNTN1
1.456e-03	-6.53	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	3	18094	50	BMPR1B,NTRK2,EFEMP1
1.468e-03	-6.52	adherens junction	cellular component	GO:0005912	188	4	19108	50	PARD3,SORBS1,PARD3B,CTNND2
1.481e-03	-6.52	contractile actin filament bundle	cellular component	GO:0097517	86	3	19108	50	SORBS1,ABLIM1,NEBL
1.481e-03	-6.52	stress fiber	cellular component	GO:0001725	86	3	19108	50	NEBL,ABLIM1,SORBS1
1.482e-03	-6.51	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	2	5310	24	PLCB1,RYR3
1.484e-03	-6.51	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	6	16828	49	MAP3K5,DCLK2,BMPR1B,FYN,PRKCA,NTRK2
1.484e-03	-6.51	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	6	16828	49	PRKCA,NTRK2,FYN,BMPR1B,DCLK2,MAP3K5
1.495e-03	-6.51	regulation of biological process	biological process	GO:0050789	12079	43	18204	50	SLC1A2,KALRN,NTRK2,MACF1,FYN,MSI2,EYA2,PITPNC1,RFX4,AHCYL1,PARD3,FMN2,PTPRZ1,HIF3A,SLC7A11,PLCB1,NRCAM,MAPK10,ATP1A2,ABCA1,RYR3,SOX5,CLU,EFEMP1,CTNND2,TRPS1,ARHGEF4,PRKCA,ADCY2,NRG3,TSHZ2,CNTN1,GPM6A,DTNA,DCLK2,GPC5,NPAS3,MAP3K5,GLIS3,BMPR1B,HPSE2,RORA,SORBS1
1.502e-03	-6.50	cell aggregation	biological process	GO:0098743	21	2	18204	50	SOX5,BMPR1B
1.502e-03	-6.50	retinal ganglion cell axon guidance	biological process	GO:0031290	21	2	18204	50	NRCAM,BMPR1B
1.503e-03	-6.50	CCNL2 (cyclin L2)	protein interactions	81669	88	3	19454	50	PRKCA,CNTN1,FYN
1.506e-03	-6.50	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	5	16828	49	SLC1A2,KALRN,ABCA1,NRG3,PARD3B
1.506e-03	-6.50	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	5	16828	49	ABCA1,KALRN,NRG3,PARD3B,SLC1A2
1.507e-03	-6.50	Axon guidance	REACTOME pathways	R-HSA-422475	549	7	10285	33	CNTN1,FYN,NRG3,NRCAM,ABLIM1,PRKCA,KALRN
1.508e-03	-6.50	YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)	protein interactions	10971	1076	9	19454	50	MAP3K5,SORBS1,MACF1,PRKCA,DCLK2,PARD3,PARD3B,ARHGEF4,ABLIM1
1.523e-03	-6.49	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	13	16828	49	NTRK2,EFEMP1,SLC1A2,CNTN1,NRCAM,PTPRZ1,SOX5,RFX4,FMN2,TRPM3,NRG3,ARHGEF4,HPSE2
1.523e-03	-6.49	functioning	COSMIC cancer mutations	functioning	1803	13	16828	49	EFEMP1,SLC1A2,NTRK2,NRCAM,CNTN1,RFX4,SOX5,FMN2,PTPRZ1,HPSE2,NRG3,ARHGEF4,TRPM3
1.530e-03	-6.48	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	48	16828	49	TRPS1,NPAS3,BMPR1B,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,PARD3,MAP3K5,EFEMP1,RYR3,EYA2,SOX5,DCLK2,PARD3B,PLCB1,PITPNC1,AHCYL1,GPM6A,KALRN,LRP1B,ATP1A2,NTRK2,HIF3A,RFX4,CLU,FMN2,PTPRZ1,FYN,ARHGEF4,GPC5,CTNND2,SORBS1,ADCY2,DTNA,NEBL,NRG3,MSI2,ABCA1,SLC1A2,PRKCA,LSAMP,RORA,NRCAM,GLIS3,CNTN1,SLC7A11
1.530e-03	-6.48	cellular response to chemical stimulus	biological process	GO:0070887	2411	15	18204	50	SLC7A11,FMN2,RORA,ATP1A2,SORBS1,PLCB1,MAP3K5,ABCA1,RYR3,SLC1A2,NTRK2,AQP4,AHCYL1,ADCY2,FYN
1.548e-03	-6.47	SFN (stratifin)	protein interactions	2810	671	7	19454	50	ABLIM1,FMN2,PARD3B,PARD3,MACF1,SORBS1,MAP3K5
1.563e-03	-6.46	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	42	16828	49	PLCB1,NEBL,SOX5,DCLK2,PARD3B,AHCYL1,NRG3,MSI2,SLC1A2,ATP1A2,ABCA1,LRP1B,KALRN,LSAMP,NTRK2,PRKCA,RORA,CNTN1,SLC7A11,HIF3A,GLIS3,NPAS3,RFX4,FMN2,FYN,BMPR1B,PTPRZ1,GPC5,HPSE2,ARHGEF4,ABLIM1,TRPM3,MACF1,CTNND2,TSHZ2,EFEMP1,PARD3,MAP3K5,ADCY2,RYR3,EYA2,DTNA
1.582e-03	-6.45	TIMM10B (translocase of inner mitochondrial membrane 10B)	protein interactions	26515	23	2	19454	50	MSI2,HPSE2
1.587e-03	-6.45	regulation of protein localization to membrane	biological process	GO:1905475	183	4	18204	50	FYN,SLC7A11,SORBS1,GPC5
1.589e-03	-6.44	regulation of sodium ion transport	biological process	GO:0002028	84	3	18204	50	ATP1A2,AHCYL1,CNTN1
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	49	16828	49	BMPR1B,NPAS3,AQP4,TRPS1,MACF1,TRPM3,TSHZ2,HPSE2,ABLIM1,RYR3,EFEMP1,PARD3,MAP3K5,EYA2,PITPNC1,PLCB1,PARD3B,SOX5,DCLK2,GPM6A,AHCYL1,NTRK2,KALRN,ATP1A2,LRP1B,HIF3A,FYN,PTPRZ1,FMN2,RFX4,CLU,CTNND2,GPC5,ARHGEF4,ADCY2,SORBS1,DTNA,NEBL,NRG3,MSI2,LSAMP,PRKCA,SLC1A2,ABCA1,SLC7A11,CNTN1,GLIS3,NRCAM,RORA
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	49	16828	49	NEBL,MSI2,NRG3,LSAMP,PRKCA,ABCA1,SLC1A2,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,PTPRZ1,FYN,FMN2,CLU,RFX4,CTNND2,ARHGEF4,GPC5,SORBS1,ADCY2,DTNA,PITPNC1,PARD3B,DCLK2,SOX5,PLCB1,GPM6A,AHCYL1,NTRK2,LRP1B,ATP1A2,KALRN,HIF3A,BMPR1B,TRPS1,AQP4,NPAS3,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,RYR3,PARD3,MAP3K5,EFEMP1,EYA2
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	49	16828	49	PITPNC1,SOX5,DCLK2,PARD3B,PLCB1,GPM6A,AHCYL1,NTRK2,KALRN,LRP1B,ATP1A2,HIF3A,BMPR1B,TRPS1,NPAS3,AQP4,TSHZ2,MACF1,TRPM3,ABLIM1,HPSE2,RYR3,MAP3K5,PARD3,EFEMP1,EYA2,NEBL,MSI2,NRG3,PRKCA,LSAMP,ABCA1,SLC1A2,GLIS3,CNTN1,SLC7A11,RORA,NRCAM,PTPRZ1,FYN,CLU,RFX4,FMN2,CTNND2,ARHGEF4,GPC5,ADCY2,SORBS1,DTNA
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	49	16828	49	NEBL,NRG3,MSI2,PRKCA,LSAMP,ABCA1,SLC1A2,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,PTPRZ1,FYN,FMN2,RFX4,CLU,CTNND2,ARHGEF4,GPC5,SORBS1,ADCY2,DTNA,PITPNC1,PARD3B,DCLK2,SOX5,PLCB1,GPM6A,AHCYL1,NTRK2,LRP1B,KALRN,ATP1A2,HIF3A,BMPR1B,TRPS1,NPAS3,AQP4,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,RYR3,PARD3,MAP3K5,EFEMP1,EYA2
1.681e-03	-6.39	classic	COSMIC cancer mutations	classic	14774	49	16828	49	DTNA,ADCY2,SORBS1,CTNND2,ARHGEF4,GPC5,PTPRZ1,FYN,RFX4,CLU,FMN2,GLIS3,CNTN1,SLC7A11,RORA,NRCAM,PRKCA,LSAMP,ABCA1,SLC1A2,MSI2,NRG3,NEBL,EYA2,RYR3,MAP3K5,PARD3,EFEMP1,TSHZ2,MACF1,TRPM3,ABLIM1,HPSE2,BMPR1B,TRPS1,NPAS3,AQP4,HIF3A,NTRK2,KALRN,ATP1A2,LRP1B,GPM6A,AHCYL1,PITPNC1,DCLK2,SOX5,PARD3B,PLCB1
1.689e-03	-6.38	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	12	16828	49	RORA,EYA2,NRCAM,CNTN1,ATP1A2,LSAMP,GPC5,MACF1,TRPS1,SOX5,PLCB1,PTPRZ1
1.704e-03	-6.38	medulla	COSMIC cancer mutations	medulla	14778	49	16828	49	NEBL,MSI2,NRG3,PRKCA,LSAMP,ABCA1,SLC1A2,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,PTPRZ1,FYN,FMN2,RFX4,CLU,CTNND2,ARHGEF4,GPC5,SORBS1,ADCY2,DTNA,PITPNC1,PARD3B,SOX5,DCLK2,PLCB1,GPM6A,AHCYL1,NTRK2,LRP1B,ATP1A2,KALRN,HIF3A,BMPR1B,TRPS1,NPAS3,AQP4,TSHZ2,MACF1,TRPM3,ABLIM1,HPSE2,RYR3,MAP3K5,PARD3,EFEMP1,EYA2
1.709e-03	-6.37	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	49	16828	49	SLC7A11,CNTN1,GLIS3,NRCAM,RORA,PRKCA,LSAMP,SLC1A2,ABCA1,NRG3,MSI2,NEBL,DTNA,ADCY2,SORBS1,CTNND2,GPC5,ARHGEF4,FYN,PTPRZ1,FMN2,CLU,RFX4,HIF3A,NTRK2,LRP1B,ATP1A2,KALRN,GPM6A,AHCYL1,PITPNC1,PLCB1,PARD3B,DCLK2,SOX5,EYA2,RYR3,EFEMP1,MAP3K5,PARD3,MACF1,TRPM3,TSHZ2,HPSE2,ABLIM1,BMPR1B,NPAS3,AQP4,TRPS1
1.715e-03	-6.37	human chr17q24.2	chromosome location	human chr17q24.2	32	2	26134	50	PRKCA,PITPNC1
1.728e-03	-6.36	regulation of signaling	biological process	GO:0023051	3534	19	18204	50	SLC7A11,GPC5,MAP3K5,PLCB1,SORBS1,ATP1A2,RORA,BMPR1B,NTRK2,KALRN,ABCA1,CTNND2,MACF1,CLU,NRG3,FYN,ARHGEF4,PRKCA,EYA2
1.738e-03	-6.35	asymmetric synapse	cellular component	GO:0032279	333	5	19108	50	KALRN,NTRK2,CTNND2,FYN,NRCAM
1.748e-03	-6.35	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	5	16828	49	MACF1,RYR3,GPC5,ABCA1,TRPS1
1.770e-03	-6.34	regulation of cell communication	biological process	GO:0010646	3541	19	18204	50	ABCA1,KALRN,NTRK2,CLU,MACF1,CTNND2,PRKCA,ARHGEF4,FYN,NRG3,EYA2,GPC5,SLC7A11,PLCB1,MAP3K5,BMPR1B,RORA,ATP1A2,SORBS1
1.797e-03	-6.32	actomyosin	cellular component	GO:0042641	92	3	19108	50	NEBL,SORBS1,ABLIM1
1.817e-03	-6.31	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	3	19454	50	NTRK2,PRKCA,FYN
1.826e-03	-6.31	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	5	16828	49	MACF1,GLIS3,PTPRZ1,TSHZ2,ABCA1
1.854e-03	-6.29	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	48	16828	49	NRG3,MSI2,NEBL,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,SLC1A2,ABCA1,LSAMP,PRKCA,GPC5,ARHGEF4,CTNND2,RFX4,CLU,FMN2,FYN,PTPRZ1,DTNA,SORBS1,ADCY2,AHCYL1,GPM6A,PLCB1,DCLK2,SOX5,PARD3B,PITPNC1,HIF3A,KALRN,ATP1A2,LRP1B,NTRK2,HPSE2,ABLIM1,TRPM3,MACF1,TSHZ2,NPAS3,TRPS1,BMPR1B,EYA2,EFEMP1,PARD3,MAP3K5,RYR3
1.854e-03	-6.29	bladder	COSMIC cancer mutations	bladder	14112	48	16828	49	ATP1A2,LRP1B,KALRN,NTRK2,HIF3A,DCLK2,SOX5,PARD3B,PLCB1,PITPNC1,AHCYL1,GPM6A,MAP3K5,PARD3,EFEMP1,RYR3,EYA2,TRPS1,NPAS3,BMPR1B,ABLIM1,HPSE2,TSHZ2,TRPM3,MACF1,ABCA1,SLC1A2,PRKCA,LSAMP,RORA,NRCAM,GLIS3,CNTN1,SLC7A11,NEBL,NRG3,MSI2,ADCY2,SORBS1,DTNA,CLU,RFX4,FMN2,PTPRZ1,FYN,ARHGEF4,GPC5,CTNND2
1.869e-03	-6.28	ATP binding	molecular function	GO:0005524	1467	11	18094	50	MAPK10,NTRK2,PRKCA,DCLK2,KALRN,FYN,MAP3K5,BMPR1B,ADCY2,ATP1A2,ABCA1
1.870e-03	-6.28	TNC (tenascin C)	protein interactions	3371	25	2	19454	50	CNTN1,CLU
1.870e-03	-6.28	RFX2 (regulatory factor X2)	protein interactions	5990	25	2	19454	50	EYA2,RFX4
1.873e-03	-6.28	LIMK1 (LIM domain kinase 1)	protein interactions	3984	95	3	19454	50	FYN,ABCA1,ATP1A2
1.874e-03	-6.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	14	16828	49	TRPS1,SOX5,DCLK2,PTPRZ1,FYN,BMPR1B,DTNA,KALRN,LRP1B,ATP1A2,ADCY2,MAP3K5,PRKCA,NTRK2
1.893e-03	-6.27	Spectrin	pfam domains	PF00435	24	2	17795	48	KALRN,MACF1
1.898e-03	-6.27	Spectrin_repeat	interpro domains	IPR002017	24	2	18521	50	MACF1,KALRN
1.913e-03	-6.26	human chr2q22.1-q22.2	chromosome location	human chr2q22.1-q22.2	1	1	26134	50	LRP1B
1.913e-03	-6.26	human chr4q31.23-q31.3	chromosome location	human chr4q31.23-q31.3	1	1	26134	50	DCLK2
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr3q21.1-q21.2	chromosome location	human chr3q21.1-q21.2	1	1	26134	50	KALRN
1.913e-03	-6.26	human chr10p11.22-p11.21	chromosome location	human chr10p11.22-p11.21	1	1	26134	50	PARD3
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.925e-03	-6.25	PTPN11 (protein tyrosine phosphatase non-receptor type 11)	protein interactions	5781	347	5	19454	50	MAP3K5,FYN,NTRK2,PRKCA,AHCYL1
1.933e-03	-6.25	cellular response to organic substance	biological process	GO:0071310	1716	12	18204	50	ADCY2,PLCB1,MAP3K5,FYN,RORA,SORBS1,ATP1A2,AHCYL1,AQP4,SLC1A2,RYR3,ABCA1
1.951e-03	-6.24	response to organic cyclic compound	biological process	GO:0014070	843	8	18204	50	PLCB1,ADCY2,ATP1A2,RORA,RYR3,ABCA1,SLC1A2,SLC7A11
1.957e-03	-6.24	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	4	16828	49	GPC5,LRP1B,NRG3,RYR3
1.983e-03	-6.22	Transcriptional activation by NRF2	WikiPathways	WP3	15	2	5310	24	SLC7A11,PRKCA
1.984e-03	-6.22	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	49	16828	49	RYR3,PARD3,MAP3K5,EFEMP1,EYA2,BMPR1B,TRPS1,NPAS3,AQP4,TSHZ2,MACF1,TRPM3,ABLIM1,HPSE2,NTRK2,LRP1B,KALRN,ATP1A2,HIF3A,PITPNC1,DCLK2,SOX5,PARD3B,PLCB1,GPM6A,AHCYL1,SORBS1,ADCY2,DTNA,PTPRZ1,FYN,RFX4,CLU,FMN2,CTNND2,ARHGEF4,GPC5,PRKCA,LSAMP,ABCA1,SLC1A2,GLIS3,CNTN1,SLC7A11,RORA,NRCAM,NEBL,NRG3,MSI2
1.987e-03	-6.22	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	3	19454	50	DCLK2,AHCYL1,CLU
1.997e-03	-6.22	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	6	16828	49	FYN,BMPR1B,NTRK2,PRKCA,DCLK2,MAP3K5
2.018e-03	-6.21	HS-GAG degradation	REACTOME pathways	R-HSA-2024096	21	2	10285	33	GPC5,HPSE2
2.023e-03	-6.20	NRCAM (neuronal cell adhesion molecule)	protein interactions	4897	26	2	19454	50	NRCAM,MACF1
2.029e-03	-6.20	postsynaptic specialization	cellular component	GO:0099572	345	5	19108	50	NRCAM,FYN,CTNND2,NTRK2,KALRN
2.030e-03	-6.20	actin filament bundle	cellular component	GO:0032432	96	3	19108	50	NEBL,SORBS1,ABLIM1
2.042e-03	-6.19	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	6	16828	49	NTRK2,PRKCA,FYN,BMPR1B,DCLK2,MAP3K5
2.047e-03	-6.19	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	3	19454	50	LSAMP,CNTN1,GPM6A
2.047e-03	-6.19	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	3	19454	50	NTRK2,SORBS1,PARD3
2.062e-03	-6.18	protein tetramerization	biological process	GO:0051262	92	3	18204	50	RYR3,TRPM3,AQP4
2.090e-03	-6.17	Regulation of insulin secretion	REACTOME pathways	R-HSA-422356	80	3	10285	33	PRKCA,AHCYL1,PLCB1
2.118e-03	-6.16	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	23	16828	49	TSHZ2,CTNND2,MACF1,ARHGEF4,MSI2,AHCYL1,PTPRZ1,PITPNC1,BMPR1B,FYN,SOX5,CLU,TRPS1,DCLK2,PLCB1,HIF3A,CNTN1,RORA,NTRK2,PRKCA,MAP3K5,KALRN,LRP1B
2.118e-03	-6.16	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	23	16828	49	MSI2,AHCYL1,PITPNC1,SOX5,DCLK2,PLCB1,CNTN1,HIF3A,RORA,PRKCA,NTRK2,LRP1B,KALRN,TSHZ2,MACF1,CTNND2,ARHGEF4,PTPRZ1,FYN,BMPR1B,TRPS1,CLU,MAP3K5
2.127e-03	-6.15	large_cell	COSMIC cancer mutations	large_cell	14845	49	16828	49	PITPNC1,DCLK2,SOX5,PARD3B,PLCB1,GPM6A,AHCYL1,NTRK2,LRP1B,KALRN,ATP1A2,HIF3A,BMPR1B,TRPS1,NPAS3,AQP4,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,RYR3,MAP3K5,PARD3,EFEMP1,EYA2,NEBL,MSI2,NRG3,PRKCA,LSAMP,ABCA1,SLC1A2,GLIS3,CNTN1,SLC7A11,RORA,NRCAM,PTPRZ1,FYN,RFX4,CLU,FMN2,CTNND2,ARHGEF4,GPC5,ADCY2,SORBS1,DTNA
2.130e-03	-6.15	cellular response to sterol	biological process	GO:0036315	25	2	18204	50	ABCA1,RORA
2.130e-03	-6.15	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	50	SLC1A2,SLC7A11
2.146e-03	-6.14	synapse organization	biological process	GO:0050808	333	5	18204	50	NRCAM,NRG3,FYN,GPM6A,CTNND2
2.170e-03	-6.13	Fc epsilon RI signaling pathway	KEGG pathways	hsa04664	67	3	7161	28	FYN,PRKCA,MAPK10
2.170e-03	-6.13	Fc epsilon RI signaling pathway	KEGG pathways	ko04664	67	3	7161	28	MAPK10,PRKCA,FYN
2.176e-03	-6.13	FN3_sf	interpro domains	IPR036116	203	4	18521	50	KALRN,PTPRZ1,NRCAM,CNTN1
2.176e-03	-6.13	FN3_dom	interpro domains	IPR003961	203	4	18521	50	PTPRZ1,KALRN,CNTN1,NRCAM
2.179e-03	-6.13	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	6	16828	49	DCLK2,MAP3K5,FYN,BMPR1B,PRKCA,NTRK2
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	ABLIM1,DTNA
2.181e-03	-6.13	HPCAL4 (hippocalcin like 4)	protein interactions	51440	27	2	19454	50	AQP4,GPM6A
2.202e-03	-6.12	camera-type eye development	biological process	GO:0043010	335	5	18204	50	SLC7A11,BMPR1B,GPM6A,EFEMP1,NTRK2
2.206e-03	-6.12	Adrenergic signaling in cardiomyocytes	KEGG pathways	ko04261	144	4	7161	28	PLCB1,PRKCA,ADCY2,ATP1A2
2.206e-03	-6.12	Adrenergic signaling in cardiomyocytes	KEGG pathways	hsa04261	144	4	7161	28	PLCB1,ATP1A2,ADCY2,PRKCA
2.215e-03	-6.11	SHC1 events in ERBB2 signaling	REACTOME pathways	R-HSA-1250196	22	2	10285	33	NRG3,PRKCA
2.217e-03	-6.11	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	9	19454	50	SORBS1,MACF1,MAP3K5,PITPNC1,PRKCA,PARD3B,PARD3,ABLIM1,ARHGEF4
2.238e-03	-6.10	modulation of chemical synaptic transmission	biological process	GO:0050804	494	6	18204	50	SLC7A11,NTRK2,ATP1A2,PLCB1,FYN,NRG3
2.261e-03	-6.09	regulation of trans-synaptic signaling	biological process	GO:0099177	495	6	18204	50	SLC7A11,NTRK2,ATP1A2,FYN,NRG3,PLCB1
2.262e-03	-6.09	Phospholipase D signaling pathway	KEGG pathways	hsa04072	145	4	7161	28	PLCB1,ADCY2,FYN,PRKCA
2.262e-03	-6.09	Phospholipase D signaling pathway	KEGG pathways	ko04072	145	4	7161	28	FYN,PRKCA,ADCY2,PLCB1
2.275e-03	-6.09	transport	biological process	GO:0006810	3615	19	18204	50	PLCB1,LRP1B,ATP1A2,FMN2,SLC7A11,FYN,TRPM3,EYA2,GPM6A,PITPNC1,AQP4,AHCYL1,RYR3,ABCA1,SLC1A2,KALRN,NTRK2,MACF1,CLU
2.285e-03	-6.08	skin-upper_back-malignant_melanoma	COSMIC cancer mutations	skin-upper_back-malignant_melanoma	319	5	16828	49	CNTN1,MACF1,GPC5,PARD3B,KALRN
2.291e-03	-6.08	CAV1 (caveolin 1)	protein interactions	857	719	7	19454	50	FMN2,DTNA,MACF1,FYN,PARD3,AHCYL1,SLC7A11
2.302e-03	-6.07	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	32	16828	49	CNTN1,HIF3A,SLC7A11,GLIS3,RORA,NRCAM,NTRK2,LRP1B,ABCA1,ATP1A2,KALRN,NRG3,NEBL,DCLK2,SOX5,PARD3B,DTNA,RYR3,ADCY2,PARD3,MAP3K5,SORBS1,TRPM3,MACF1,CTNND2,TSHZ2,ABLIM1,FYN,PTPRZ1,NPAS3,TRPS1,FMN2
2.304e-03	-6.07	central nervous system myelination	biological process	GO:0022010	26	2	18204	50	CNTN1,CLU
2.304e-03	-6.07	axon ensheathment in central nervous system	biological process	GO:0032291	26	2	18204	50	CLU,CNTN1
2.319e-03	-6.07	CTNNB1 (catenin beta 1)	protein interactions	1499	926	8	19454	50	PRKCA,PTPRZ1,DTNA,SORBS1,FYN,PARD3,CTNND2,PARD3B
2.358e-03	-6.05	Pkinase	pfam domains	PF00069	347	5	17795	48	PRKCA,MAPK10,DCLK2,KALRN,MAP3K5
2.362e-03	-6.05	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	48	16828	49	ARHGEF4,GPC5,CTNND2,FMN2,RFX4,CLU,PTPRZ1,FYN,DTNA,ADCY2,SORBS1,NRG3,NEBL,NRCAM,RORA,GLIS3,SLC7A11,CNTN1,ABCA1,SLC1A2,LSAMP,PRKCA,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,TRPS1,AQP4,NPAS3,BMPR1B,EYA2,PARD3,MAP3K5,EFEMP1,RYR3,AHCYL1,GPM6A,PARD3B,SOX5,DCLK2,PLCB1,PITPNC1,HIF3A,ATP1A2,LRP1B,KALRN,NTRK2
2.398e-03	-6.03	DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5)	protein interactions	80331	365	5	19454	50	PARD3,MACF1,DTNA,CLU,AHCYL1
2.399e-03	-6.03	calcium ion transmembrane transport	biological process	GO:0070588	205	4	18204	50	TRPM3,GPM6A,RYR3,PLCB1
2.424e-03	-6.02	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	3	19454	50	SORBS1,ABLIM1,CLU
2.440e-03	-6.02	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	11	16828	49	PARD3,FMN2,SORBS1,LRP1B,TRPS1,RYR3,LSAMP,GPC5,CTNND2,CNTN1,TRPM3
2.455e-03	-6.01	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	5	19454	50	CLU,ABLIM1,NTRK2,AHCYL1,PARD3
2.476e-03	-6.00	parathyroid	COSMIC cancer mutations	parathyroid	476	6	16828	49	ABCA1,TRPS1,RYR3,GPC5,MACF1,GPM6A
2.495e-03	-5.99	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	37	16828	49	SOX5,DCLK2,PARD3B,NEBL,PLCB1,PITPNC1,MSI2,KALRN,ATP1A2,LRP1B,PRKCA,LSAMP,NTRK2,RORA,GLIS3,CNTN1,HIF3A,SLC7A11,CLU,TRPS1,FMN2,PTPRZ1,FYN,BMPR1B,ARHGEF4,GPC5,HPSE2,TSHZ2,MACF1,TRPM3,CTNND2,SORBS1,MAP3K5,ADCY2,EFEMP1,RYR3,EYA2
2.496e-03	-5.99	system process	biological process	GO:0003008	2015	13	18204	50	NTRK2,SLC1A2,RYR3,EFEMP1,FYN,AQP4,DTNA,SLC7A11,PTPRZ1,NRCAM,PLCB1,ATP1A2,ABLIM1
2.498e-03	-5.99	cellular response to organonitrogen compound	biological process	GO:0071417	505	6	18204	50	SLC1A2,RYR3,FYN,PLCB1,AHCYL1,SORBS1
2.498e-03	-5.99	response to inorganic substance	biological process	GO:0010035	505	6	18204	50	RYR3,AHCYL1,ATP1A2,PLCB1,FYN,MAP3K5
2.514e-03	-5.99	INSC (INSC spindle orientation adaptor protein)	protein interactions	387755	29	2	19454	50	PARD3,PARD3B
2.514e-03	-5.99	CD5 (CD5 molecule)	protein interactions	921	29	2	19454	50	FYN,PRKCA
2.562e-03	-5.97	Bile secretion	KEGG pathways	ko04976	71	3	7161	28	ATP1A2,AQP4,ADCY2
2.562e-03	-5.97	Bile secretion	KEGG pathways	hsa04976	71	3	7161	28	ATP1A2,AQP4,ADCY2
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	TAS2R20 (taste 2 receptor member 20)	protein interactions	259295	1	1	19454	50	PRKCA
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Cntnap2 (contactin associated protein-like 2)	protein interactions	66797	1	1	19454	50	CNTN1
2.570e-03	-5.96	Efs (embryonal Fyn-associated substrate)	protein interactions	13644	1	1	19454	50	FYN
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	App (amyloid beta precursor protein)	protein interactions	100689222	1	1	19454	50	LRP1B
2.570e-03	-5.96	Hectd1 (HECT domain E3 ubiquitin protein ligase 1)	protein interactions	100762999	1	1	19454	50	ABCA1
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	fbxw7.L (F-box and WD repeat domain containing 7 L homeolog)	protein interactions	734230	1	1	19454	50	PRKCA
2.577e-03	-5.96	upper_back	COSMIC cancer mutations	upper_back	328	5	16828	49	CNTN1,MACF1,KALRN,PARD3B,GPC5
2.581e-03	-5.96	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	11	18094	50	ATP1A2,ADCY2,ABCA1,MAP3K5,BMPR1B,KALRN,FYN,PRKCA,DCLK2,MAPK10,NTRK2
2.587e-03	-5.96	regulation of developmental process	biological process	GO:0050793	2540	15	18204	50	RORA,BMPR1B,MAP3K5,NRCAM,PLCB1,PTPRZ1,PARD3,FYN,PRKCA,TRPS1,EFEMP1,MACF1,SOX5,NTRK2,ABCA1
2.590e-03	-5.96	neuron to neuron synapse	cellular component	GO:0098984	365	5	19108	50	NRCAM,FYN,CTNND2,NTRK2,KALRN
2.617e-03	-5.95	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	50	CLU
2.643e-03	-5.94	regulation of localization	biological process	GO:0032879	2028	13	18204	50	SLC1A2,RYR3,ABCA1,CLU,FYN,CNTN1,AHCYL1,DCLK2,GPC5,SLC7A11,PLCB1,SORBS1,ATP1A2
2.646e-03	-5.93	skin-ankle-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-ankle-malignant_melanoma-acral_lentiginous	330	5	16828	49	TSHZ2,PARD3,KALRN,NRG3,PLCB1
2.666e-03	-5.93	Adherens junction	KEGG pathways	hsa04520	72	3	7161	28	PARD3,SORBS1,FYN
2.666e-03	-5.93	Adherens junction	KEGG pathways	ko04520	72	3	7161	28	PARD3,FYN,SORBS1
2.686e-03	-5.92	Oxytocin signaling pathway	KEGG pathways	ko04921	152	4	7161	28	PLCB1,RYR3,ADCY2,PRKCA
2.686e-03	-5.92	Oxytocin signaling pathway	KEGG pathways	hsa04921	152	4	7161	28	PRKCA,ADCY2,RYR3,PLCB1
2.698e-03	-5.92	response to oxygen-containing compound	biological process	GO:1901700	1546	11	18204	50	PLCB1,ADCY2,FYN,MAP3K5,RORA,AHCYL1,ATP1A2,SORBS1,ABCA1,RYR3,SLC1A2
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	Fyn/Yrk_SH2	interpro domains	IPR047924	1	1	18521	50	FYN
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.700e-03	-5.91	Fyn/Yrk_SH3	interpro domains	IPR035750	1	1	18521	50	FYN
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	Contactin-1_Ig3	interpro domains	IPR047100	1	1	18521	50	CNTN1
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	PLC-beta1_EF	interpro domains	IPR028400	1	1	18521	50	PLCB1
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	cPKC_alpha	interpro domains	IPR034663	1	1	18521	50	PRKCA
2.700e-03	-5.91	Contactin-1_Ig6	interpro domains	IPR047101	1	1	18521	50	CNTN1
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	Contactin-1_Ig1	interpro domains	IPR036992	1	1	18521	50	CNTN1
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	NRG3,NEBL,SLC7A11,CNTN1,GLIS3,NRCAM,RORA,LSAMP,PRKCA,SLC1A2,ABCA1,CTNND2,GPC5,ARHGEF4,FYN,PTPRZ1,FMN2,CLU,RFX4,DTNA,SORBS1,ADCY2,GPM6A,AHCYL1,PITPNC1,PLCB1,PARD3B,DCLK2,SOX5,HIF3A,NTRK2,ATP1A2,LRP1B,KALRN,TRPM3,MACF1,TSHZ2,HPSE2,ABLIM1,BMPR1B,AQP4,NPAS3,TRPS1,EYA2,RYR3,EFEMP1,PARD3,MAP3K5
2.731e-03	-5.90	PRKCD (protein kinase C delta)	protein interactions	5580	227	4	19454	50	PRKCA,PLCB1,FYN,MACF1
2.747e-03	-5.90	regulation of CD24 production	biological process	GO:2000559	1	1	18204	50	PLCB1
2.747e-03	-5.90	regulation of cysteine metabolic process	biological process	GO:1901494	1	1	18204	50	SLC7A11
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.747e-03	-5.90	response to singlet oxygen	biological process	GO:0000304	1	1	18204	50	FYN
2.747e-03	-5.90	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	50	FMN2
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	50	NTRK2
2.747e-03	-5.90	positive regulation of angiotensin-activated signaling pathway	biological process	GO:0110063	1	1	18204	50	PRKCA
2.747e-03	-5.90	cellular response to glyceraldehyde	biological process	GO:1905631	1	1	18204	50	PLCB1
2.747e-03	-5.90	positive regulation of CD24 production	biological process	GO:2000560	1	1	18204	50	PLCB1
2.747e-03	-5.90	L-kynurenine transmembrane transport	biological process	GO:0140924	1	1	18204	50	SLC7A11
2.747e-03	-5.90	response to glyceraldehyde	biological process	GO:1905630	1	1	18204	50	PLCB1
2.747e-03	-5.90	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	50	CLU
2.747e-03	-5.90	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	50	NRG3
2.747e-03	-5.90	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	50	CLU
2.747e-03	-5.90	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	50	NRG3
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	50	NTRK2
2.761e-03	-5.89	Hydrolase	pfam domains	PF00702	29	2	17795	48	EYA2,ATP1A2
2.763e-03	-5.89	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	50	NTRK2
2.763e-03	-5.89	cystine:glutamate antiporter activity	molecular function	GO:0015327	1	1	18094	50	SLC7A11
2.763e-03	-5.89	cystine secondary active transmembrane transporter activity	molecular function	GO:0015328	1	1	18094	50	SLC7A11
2.763e-03	-5.89	L-kynurenine transmembrane transporter activity	molecular function	GO:0140926	1	1	18094	50	SLC7A11
2.769e-03	-5.89	S_TKc	smart domains	SM00220	348	6	9717	40	KALRN,PRKCA,MAP3K5,MAPK10,BMPR1B,DCLK2
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	HIF3A,ATP1A2,KALRN,LRP1B,NTRK2,AHCYL1,GPM6A,PLCB1,DCLK2,SOX5,PARD3B,PITPNC1,EYA2,EFEMP1,MAP3K5,PARD3,RYR3,HPSE2,ABLIM1,MACF1,TRPM3,TSHZ2,NPAS3,AQP4,TRPS1,BMPR1B,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,SLC1A2,ABCA1,PRKCA,LSAMP,NRG3,NEBL,DTNA,SORBS1,ADCY2,GPC5,ARHGEF4,CTNND2,CLU,RFX4,FMN2,FYN,PTPRZ1
2.813e-03	-5.87	IGc2	smart domains	SM00408	239	5	9717	40	NTRK2,NRCAM,KALRN,CNTN1,LSAMP
2.863e-03	-5.86	myelination in peripheral nervous system	biological process	GO:0022011	29	2	18204	50	PARD3,NTRK2
2.863e-03	-5.86	negative regulation of amyloid-beta formation	biological process	GO:1902430	29	2	18204	50	CLU,NTRK2
2.863e-03	-5.86	peripheral nervous system axon ensheathment	biological process	GO:0032292	29	2	18204	50	NTRK2,PARD3
2.870e-03	-5.85	AVPR1B (arginine vasopressin receptor 1B)	protein interactions	553	31	2	19454	50	FMN2,PRKCA
2.870e-03	-5.85	KCNA3 (potassium voltage-gated channel subfamily A member 3)	protein interactions	3738	31	2	19454	50	NTRK2,FYN
2.916e-03	-5.84	TERT (telomerase reverse transcriptase)	protein interactions	7015	111	3	19454	50	MAP3K5,SLC7A11,PRKCA
2.925e-03	-5.83	SH3_1	pfam domains	PF00018	106	3	17795	48	ARHGEF4,SORBS1,FYN
2.932e-03	-5.83	RHOA (ras homolog family member A)	protein interactions	387	1186	9	19454	50	ARHGEF4,PARD3B,FYN,PARD3,FMN2,SLC7A11,PRKCA,AHCYL1,MACF1
2.938e-03	-5.83	Cadmium Induces DNA Synthesis and Proliferation in Macrophages	SMPDB pathways	SMP0063805	20	2	1369	6	PRKCA,PLCB1
2.953e-03	-5.82	cEGF	pfam domains	PF12662	30	2	17795	48	EFEMP1,LRP1B
2.957e-03	-5.82	MAPK (JNK) signaling	KEGG pathways	M00688	21	2	7161	28	MAPK10,MAP3K5
2.957e-03	-5.82	MAPK (JNK) signaling	KEGG pathways	hsa_M00688	21	2	7161	28	MAP3K5,MAPK10
2.961e-03	-5.82	cEGF	interpro domains	IPR026823	30	2	18521	50	LRP1B,EFEMP1
2.961e-03	-5.82	Spectrin/alpha-actinin	interpro domains	IPR018159	30	2	18521	50	KALRN,MACF1
2.978e-03	-5.82	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	6	19454	50	AHCYL1,PLCB1,PARD3,FMN2,DTNA,MACF1
3.002e-03	-5.81	response to interleukin-1	biological process	GO:0070555	105	3	18204	50	PRKCA,PLCB1,RORA
3.041e-03	-5.80	positive regulation of cell projection organization	biological process	GO:0031346	361	5	18204	50	GPM6A,MACF1,CNTN1,NTRK2,FYN
3.055e-03	-5.79	CDH1 (cadherin 1)	protein interactions	999	757	7	19454	50	NEBL,MACF1,SORBS1,ABLIM1,CTNND2,PARD3,FYN
3.062e-03	-5.79	neurotransmitter uptake	biological process	GO:0001504	30	2	18204	50	ATP1A2,SLC1A2
3.062e-03	-5.79	L-glutamate import	biological process	GO:0051938	30	2	18204	50	SLC7A11,SLC1A2
3.067e-03	-5.79	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	3	19454	50	DTNA,EFEMP1,KALRN
3.093e-03	-5.78	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	4	19454	50	NTRK2,DTNA,MACF1,PARD3
3.114e-03	-5.77	SH3DOMAIN	prints domains	PR00452	83	3	5227	19	NEBL,FYN,SORBS1
3.157e-03	-5.76	protein serine kinase activity	molecular function	GO:0106310	362	5	18094	50	KALRN,DCLK2,PRKCA,MAP3K5,MAPK10
3.160e-03	-5.76	FN3	smart domains	SM00060	149	4	9717	40	NRCAM,PTPRZ1,KALRN,CNTN1
3.168e-03	-5.75	cell body	cellular component	GO:0044297	556	6	19108	50	ATP1A2,GPM6A,BMPR1B,CTNND2,SLC1A2,FYN
3.220e-03	-5.74	steroid binding	molecular function	GO:0005496	107	3	18094	50	ABCA1,RORA,ATP1A2
3.222e-03	-5.74	SMAD7 (SMAD family member 7)	protein interactions	4092	115	3	19454	50	SOX5,PARD3,BMPR1B
3.224e-03	-5.74	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	6	16828	49	MAP3K5,DCLK2,PRKCA,NTRK2,BMPR1B,FYN
3.237e-03	-5.73	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	4	19454	50	MACF1,NRCAM,LRP1B,CLU
3.249e-03	-5.73	FLACC1 (flagellum associated containing coiled-coil domains 1)	protein interactions	130540	33	2	19454	50	FYN,PRKCA
3.249e-03	-5.73	TRPC3 (transient receptor potential cation channel subfamily C member 3)	protein interactions	7222	33	2	19454	50	PRKCA,PLCB1
3.249e-03	-5.73	NTM (neurotrimin)	protein interactions	50863	33	2	19454	50	GPM6A,LSAMP
3.267e-03	-5.72	positive regulation of sodium ion transport	biological process	GO:0010765	31	2	18204	50	AHCYL1,CNTN1
3.267e-03	-5.72	negative regulation of amyloid precursor protein catabolic process	biological process	GO:1902992	31	2	18204	50	CLU,NTRK2
3.279e-03	-5.72	RHOD (ras homolog family member D)	protein interactions	29984	570	6	19454	50	AHCYL1,SLC7A11,BMPR1B,FMN2,MACF1,PARD3
3.353e-03	-5.70	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	12	19454	50	PARD3,NRG3,ARHGEF4,MSI2,MACF1,TSHZ2,PARD3B,DCLK2,ABLIM1,TRPS1,DTNA,BMPR1B
3.385e-03	-5.69	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	4	19454	50	ABCA1,NTRK2,CTNND2,PARD3
3.418e-03	-5.68	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	6	16828	49	MAP3K5,DCLK2,BMPR1B,FYN,NTRK2,PRKCA
3.446e-03	-5.67	PRKCH (protein kinase C eta)	protein interactions	5583	34	2	19454	50	PRKCA,FYN
3.479e-03	-5.66	microtubule organizing center localization	biological process	GO:0061842	32	2	18204	50	PARD3,PARD3B
3.479e-03	-5.66	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	50	SOX5,BMPR1B
3.479e-03	-5.66	centrosome localization	biological process	GO:0051642	32	2	18204	50	PARD3,PARD3B
3.479e-03	-5.66	dendritic spine organization	biological process	GO:0097061	32	2	18204	50	FYN,CTNND2
3.479e-03	-5.66	transepithelial transport	biological process	GO:0070633	32	2	18204	50	AHCYL1,SLC1A2
3.582e-03	-5.63	CaM pathway	REACTOME pathways	R-HSA-111997	28	2	10285	33	PRKCA,ADCY2
3.582e-03	-5.63	Calmodulin induced events	REACTOME pathways	R-HSA-111933	28	2	10285	33	PRKCA,ADCY2
3.635e-03	-5.62	AQUAPORIN4	prints domains	PR02016	1	1	5227	19	AQP4
3.635e-03	-5.62	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	19	NTRK2
3.649e-03	-5.61	Mbp (myelin basic protein)	protein interactions	17196	35	2	19454	50	FYN,MAP3K5
3.655e-03	-5.61	atypical	COSMIC cancer mutations	atypical	515	6	16828	49	BMPR1B,FYN,NTRK2,PRKCA,MAP3K5,DCLK2
3.693e-03	-5.60	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	45	CLU
3.693e-03	-5.60	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	45	CLU
3.707e-03	-5.60	cation binding	molecular function	GO:0043169	4341	21	18094	50	LRP1B,SLC1A2,BMPR1B,ATP1A2,ABCA1,TRPS1,EYA2,KALRN,EFEMP1,MACF1,PRKCA,MAP3K5,ABLIM1,TSHZ2,GLIS3,PLCB1,ADCY2,RYR3,DTNA,FYN,RORA
3.724e-03	-5.59	nervous system process	biological process	GO:0050877	1376	10	18204	50	NTRK2,SLC7A11,PTPRZ1,EFEMP1,FYN,NRCAM,PLCB1,ATP1A2,AQP4,ABLIM1
3.792e-03	-5.57	PAS	interpro domains	IPR000014	34	2	18521	50	HIF3A,NPAS3
3.792e-03	-5.57	PAS-like_dom_sf	interpro domains	IPR035965	34	2	18521	50	NPAS3,HIF3A
3.819e-03	-5.57	MARCKS (myristoylated alanine rich protein kinase C substrate)	protein interactions	4082	588	6	19454	50	MACF1,DTNA,AHCYL1,PRKCA,SLC7A11,ABLIM1
3.827e-03	-5.57	eye development	biological process	GO:0001654	381	5	18204	50	BMPR1B,EFEMP1,GPM6A,SLC7A11,NTRK2
3.857e-03	-5.56	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	3	7161	28	ADCY2,PRKCA,PLCB1
3.857e-03	-5.56	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	3	7161	28	PLCB1,ADCY2,PRKCA
3.857e-03	-5.56	PTPRB (protein tyrosine phosphatase receptor type B)	protein interactions	5787	36	2	19454	50	CNTN1,NRCAM
3.919e-03	-5.54	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	33	SORBS1,RYR3,AHCYL1,ATP1A2
3.921e-03	-5.54	negative regulation of amide metabolic process	biological process	GO:0034249	34	2	18204	50	CLU,NTRK2
3.936e-03	-5.54	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	21	16828	49	PARD3B,FMN2,CLU,TRPS1,AQP4,NPAS3,PTPRZ1,ARHGEF4,TSHZ2,CTNND2,TRPM3,MACF1,SORBS1,ADCY2,MAP3K5,PARD3,LRP1B,ABCA1,RYR3,RORA,GLIS3
3.972e-03	-5.53	negative regulation of programmed cell death	biological process	GO:0043069	946	8	18204	50	FMN2,PRKCA,NTRK2,FYN,CLU,EYA2,SLC7A11,PTPRZ1
4.001e-03	-5.52	visual system development	biological process	GO:0150063	385	5	18204	50	GPM6A,EFEMP1,BMPR1B,SLC7A11,NTRK2
4.015e-03	-5.52	positive regulation of biological process	biological process	GO:0048518	6326	27	18204	50	PTPRZ1,FMN2,ATP1A2,PLCB1,NRCAM,MACF1,SLC1A2,NTRK2,EYA2,RFX4,AHCYL1,PARD3,FYN,GPC5,NPAS3,BMPR1B,HPSE2,RORA,SORBS1,MAP3K5,GLIS3,CLU,ABCA1,SOX5,CNTN1,GPM6A,PRKCA
4.062e-03	-5.51	adenyl nucleotide binding	molecular function	GO:0030554	1620	11	18094	50	NTRK2,MAPK10,FYN,KALRN,DCLK2,PRKCA,BMPR1B,MAP3K5,ABCA1,ATP1A2,ADCY2
4.071e-03	-5.50	Mta1 (metastasis associated 1)	protein interactions	116870	37	2	19454	50	TRPS1,FYN
4.071e-03	-5.50	CTNND2 (catenin delta 2)	protein interactions	1501	37	2	19454	50	CTNND2,FYN
4.071e-03	-5.50	PRRG4 (proline rich and Gla domain 4)	protein interactions	79056	37	2	19454	50	FYN,NEBL
4.102e-03	-5.50	Ig_sub	interpro domains	IPR003599	394	5	18521	50	LSAMP,NRCAM,CNTN1,KALRN,NTRK2
4.106e-03	-5.50	Ca-dependent events	REACTOME pathways	R-HSA-111996	30	2	10285	33	ADCY2,PRKCA
4.116e-03	-5.49	DELLA	smart domains	SM01129	1	1	9717	40	MACF1
4.140e-03	-5.49	calcium channel activity	molecular function	GO:0005262	117	3	18094	50	GPM6A,RYR3,TRPM3
4.152e-03	-5.48	response to sterol	biological process	GO:0036314	35	2	18204	50	ABCA1,RORA
4.169e-03	-5.48	synapse assembly	biological process	GO:0007416	118	3	18204	50	GPM6A,NRG3,NRCAM
4.268e-03	-5.46	ErbB signaling pathway	KEGG pathways	hsa04012	85	3	7161	28	PRKCA,NRG3,MAPK10
4.268e-03	-5.46	ErbB signaling pathway	KEGG pathways	ko04012	85	3	7161	28	MAPK10,NRG3,PRKCA
4.271e-03	-5.46	sensory system development	biological process	GO:0048880	391	5	18204	50	NTRK2,SLC7A11,BMPR1B,EFEMP1,GPM6A
4.281e-03	-5.45	cell adhesion molecule binding	molecular function	GO:0050839	560	6	18094	50	CNTN1,PRKCA,MACF1,PTPRZ1,CTNND2,NRCAM
4.290e-03	-5.45	EGLN2 (egl-9 family hypoxia inducible factor 2)	protein interactions	112398	38	2	19454	50	HIF3A,PRKCA
4.316e-03	-5.45	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	10	19454	50	EFEMP1,ADCY2,FYN,SLC1A2,PRKCA,PLCB1,MAPK10,NTRK2,BMPR1B,MAP3K5
4.335e-03	-5.44	thyroid	COSMIC cancer mutations	thyroid	9867	38	16828	49	NRG3,AHCYL1,PARD3B,DCLK2,SOX5,PLCB1,NRCAM,RORA,GLIS3,SLC7A11,HIF3A,CNTN1,LRP1B,ABCA1,ATP1A2,KALRN,SLC1A2,LSAMP,PRKCA,ARHGEF4,ABLIM1,GPC5,TSHZ2,CTNND2,TRPM3,MACF1,FMN2,CLU,TRPS1,AQP4,PTPRZ1,FYN,EYA2,DTNA,MAP3K5,PARD3,ADCY2,RYR3
4.344e-03	-5.44	glutamatergic synapse	cellular component	GO:0098978	412	5	19108	50	SLC1A2,NRG3,GPM6A,NRCAM,PLCB1
4.356e-03	-5.44	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	22	16828	49	TRPS1,CLU,FMN2,PTPRZ1,FYN,BMPR1B,ARHGEF4,TSHZ2,CTNND2,MAP3K5,DCLK2,SOX5,PLCB1,PITPNC1,MSI2,KALRN,LRP1B,NTRK2,PRKCA,RORA,CNTN1,HIF3A
4.370e-03	-5.43	striated muscle contraction	biological process	GO:0006941	120	3	18204	50	RYR3,DTNA,ATP1A2
4.383e-03	-5.43	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	4	16828	49	HPSE2,LRP1B,KALRN,CTNND2
4.388e-03	-5.43	lamellipodium assembly	biological process	GO:0030032	36	2	18204	50	ARHGEF4,ABLIM1
4.448e-03	-5.42	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	3	16828	49	RYR3,SOX5,SLC1A2
4.451e-03	-5.41	anatomical structure formation involved in morphogenesis	biological process	GO:0048646	964	8	18204	50	PRKCA,NRCAM,NRG3,EYA2,CNTN1,RORA,NEBL,HIF3A
4.494e-03	-5.41	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	4	19454	50	MACF1,DTNA,FMN2,PARD3
4.577e-03	-5.39	ion binding	molecular function	GO:0043167	6007	26	18094	50	MAPK10,EYA2,MACF1,EFEMP1,BMPR1B,ABCA1,NTRK2,RYR3,PARD3,PITPNC1,ABLIM1,TSHZ2,PLCB1,ADCY2,GLIS3,TRPS1,PRKCA,DCLK2,KALRN,SLC1A2,LRP1B,ATP1A2,DTNA,RORA,FYN,MAP3K5
4.631e-03	-5.38	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	50	SORBS1,SLC1A2
4.646e-03	-5.37	anion binding	molecular function	GO:0043168	2412	14	18094	50	MAPK10,KALRN,DCLK2,PRKCA,BMPR1B,ABCA1,ATP1A2,NTRK2,PITPNC1,FYN,PARD3,MAP3K5,ADCY2,PLCB1
4.648e-03	-5.37	positive regulation of cellular process	biological process	GO:0048522	5719	25	18204	50	ABCA1,SOX5,CLU,PRKCA,GPM6A,CNTN1,GPC5,NPAS3,MAP3K5,GLIS3,RORA,HPSE2,BMPR1B,SORBS1,SLC1A2,NTRK2,MACF1,FYN,EYA2,PARD3,RFX4,FMN2,PTPRZ1,NRCAM,PLCB1
4.669e-03	-5.37	PAS	smart domains	SM00091	25	2	9717	40	NPAS3,HIF3A
4.705e-03	-5.36	Gap junction	KEGG pathways	ko04540	88	3	7161	28	PRKCA,ADCY2,PLCB1
4.705e-03	-5.36	Gap junction	KEGG pathways	hsa04540	88	3	7161	28	PLCB1,ADCY2,PRKCA
4.738e-03	-5.35	Endothelins	Pathway Interaction DB	endothelinpathway	53	3	2226	15	PLCB1,PRKCA,ADCY2
4.744e-03	-5.35	DZIP1 (DAZ interacting zinc finger protein 1)	protein interactions	22873	40	2	19454	50	NTRK2,PARD3
4.750e-03	-5.35	RAC3 (Rac family small GTPase 3)	protein interactions	5881	615	6	19454	50	FMN2,PARD3,AHCYL1,SLC7A11,MACF1,GPM6A
4.788e-03	-5.34	action potential	biological process	GO:0001508	124	3	18204	50	ATP1A2,NTRK2,NRCAM
4.880e-03	-5.32	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	50	SLC7A11,SLC1A2
4.880e-03	-5.32	fluid transport	biological process	GO:0042044	38	2	18204	50	AHCYL1,AQP4
4.882e-03	-5.32	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	4	10285	33	ADCY2,PLCB1,PRKCA,SLC1A2
4.912e-03	-5.32	central_nervous_system-thalamus-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-thalamus-glioma-oligodendroglioma_Grade_III	36	2	16828	49	TSHZ2,ABCA1
4.917e-03	-5.31	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	7	10285	33	SLC1A2,ATP1A2,AQP4,SLC7A11,ADCY2,RYR3,TRPM3
4.919e-03	-5.31	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	5	10285	33	AHCYL1,ADCY2,FYN,PRKCA,NRG3
4.934e-03	-5.31	VCL (vinculin)	protein interactions	7414	268	4	19454	50	PRKCA,NEBL,SORBS1,MACF1
4.977e-03	-5.30	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	21	16828	49	ARHGEF4,TSHZ2,CTNND2,TRPM3,MACF1,FMN2,PARD3B,CLU,TRPS1,AQP4,NPAS3,PTPRZ1,RORA,GLIS3,PARD3,MAP3K5,SORBS1,ADCY2,LRP1B,ABCA1,RYR3
4.980e-03	-5.30	RASSF7 (Ras association domain family member 7)	protein interactions	8045	41	2	19454	50	PARD3,CLU
4.988e-03	-5.30	skin-leg-malignant_melanoma	COSMIC cancer mutations	skin-leg-malignant_melanoma	549	6	16828	49	LRP1B,PLCB1,NEBL,PTPRZ1,NRG3,HIF3A
5.029e-03	-5.29	Calcium signaling pathway	KEGG pathways	hsa04020	181	4	7161	28	RYR3,PLCB1,PRKCA,ADCY2
5.029e-03	-5.29	Calcium signaling pathway	KEGG pathways	ko04020	181	4	7161	28	PRKCA,ADCY2,RYR3,PLCB1
5.118e-03	-5.28	response to amino acid	biological process	GO:0043200	127	3	18204	50	SLC1A2,NTRK2,FYN
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	RYR3,MACF1,DTNA,PLCB1
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Grin2c (glutamate ionotropic receptor NMDA type subunit 2C)	protein interactions	24411	2	1	19454	50	PRKCA
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	numb (numb)	protein interactions	34263	2	1	19454	50	PRKCA
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	cellular response to alkaloid	biological process	GO:0071312	39	2	18204	50	RYR3,SLC1A2
5.157e-03	-5.27	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	8	16828	49	MACF1,NTRK2,PRKCA,FYN,BMPR1B,DCLK2,ATP1A2,MAP3K5
5.159e-03	-5.27	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	5	10285	33	AHCYL1,ADCY2,FYN,PRKCA,NRG3
5.184e-03	-5.26	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	3	17795	48	BMPR1B,NTRK2,FYN
5.198e-03	-5.26	RDX (radixin)	protein interactions	5962	272	4	19454	50	MAPK10,NEBL,ABLIM1,MACF1
5.220e-03	-5.26	GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)	protein interactions	2891	42	2	19454	50	PRKCA,GPM6A
5.265e-03	-5.25	FLOT2 (flotillin 2)	protein interactions	2319	273	4	19454	50	FYN,PARD3,SOX5,NTRK2
5.299e-03	-5.24	protein complex oligomerization	biological process	GO:0051259	256	4	18204	50	SLC1A2,RYR3,TRPM3,AQP4
5.375e-03	-5.23	FN3	prosite domains	PS50853	192	4	12186	45	NRCAM,CNTN1,KALRN,PTPRZ1
5.385e-03	-5.22	Insulin Signaling	WikiPathways	WP481	161	4	5310	24	MAPK10,MAP3K5,SORBS1,PRKCA
5.388e-03	-5.22	Clusterin	pfam domains	PF01093	2	1	17795	48	CLU
5.388e-03	-5.22	Glyco_hydro_79n	pfam domains	PF03662	2	1	17795	48	HPSE2
5.388e-03	-5.22	DUF5050	pfam domains	PF16472	2	1	17795	48	LRP1B
5.388e-03	-5.22	SH3-RhoG_link	pfam domains	PF16609	2	1	17795	48	KALRN
5.388e-03	-5.22	DUF1154	pfam domains	PF06631	2	1	17795	48	PLCB1
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	Glyco_hydro_79	interpro domains	IPR005199	2	1	18521	50	HPSE2
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.392e-03	-5.22	Contactin-1_2_Ig1	interpro domains	IPR047102	2	1	18521	50	CNTN1
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	LRP1-like_beta_prop	interpro domains	IPR032485	2	1	18521	50	LRP1B
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Kalirin_TRIO_PH_1	interpro domains	IPR047054	2	1	18521	50	KALRN
5.392e-03	-5.22	PLC-beta_CS	interpro domains	IPR009535	2	1	18521	50	PLCB1
5.392e-03	-5.22	Kalirin_TRIO_SH3_1	interpro domains	IPR028570	2	1	18521	50	KALRN
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Kalirin_TRIO_SH3_2	interpro domains	IPR047053	2	1	18521	50	KALRN
5.395e-03	-5.22	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	2	18204	50	ADCY2,RORA
5.425e-03	-5.22	transporter activity	molecular function	GO:0005215	1211	9	18094	50	ABCA1,ATP1A2,SLC7A11,SLC1A2,TRPM3,PITPNC1,GPM6A,RYR3,AQP4
5.431e-03	-5.22	PAS	prosite domains	PS50112	30	2	12186	45	HIF3A,NPAS3
5.462e-03	-5.21	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	49	16828	49	NEBL,MSI2,NRG3,SLC1A2,ABCA1,PRKCA,LSAMP,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,RFX4,CLU,FMN2,FYN,PTPRZ1,GPC5,ARHGEF4,CTNND2,ADCY2,SORBS1,DTNA,PLCB1,DCLK2,SOX5,PARD3B,PITPNC1,AHCYL1,GPM6A,LRP1B,ATP1A2,KALRN,NTRK2,HIF3A,AQP4,NPAS3,TRPS1,BMPR1B,HPSE2,ABLIM1,TRPM3,MACF1,TSHZ2,EFEMP1,PARD3,MAP3K5,RYR3,EYA2
5.466e-03	-5.21	C2CD4B (C2 calcium dependent domain containing 4B)	protein interactions	388125	43	2	19454	50	LRP1B,MACF1
5.486e-03	-5.21	positive regulation of dense core granule biogenesis	biological process	GO:2000707	2	1	18204	50	PRKCA
5.486e-03	-5.21	cellular response to glycine	biological process	GO:1905430	2	1	18204	50	FYN
5.486e-03	-5.21	positive regulation of high-density lipoprotein particle assembly	biological process	GO:0090108	2	1	18204	50	ABCA1
5.486e-03	-5.21	regulation of glutathione biosynthetic process	biological process	GO:1903786	2	1	18204	50	SLC7A11
5.486e-03	-5.21	cellular response to fluoride	biological process	GO:1902618	2	1	18204	50	PLCB1
5.486e-03	-5.21	negative regulation of monocyte extravasation	biological process	GO:2000438	2	1	18204	50	PLCB1
5.486e-03	-5.21	activation of meiosis involved in egg activation	biological process	GO:0060466	2	1	18204	50	PLCB1
5.486e-03	-5.21	phosphatidylinositol catabolic process	biological process	GO:0031161	2	1	18204	50	PLCB1
5.486e-03	-5.21	neuron intrinsic apoptotic signaling pathway in response to oxidative stress	biological process	GO:0036480	2	1	18204	50	MAP3K5
5.486e-03	-5.21	regulation of sulfur amino acid metabolic process	biological process	GO:0031335	2	1	18204	50	SLC7A11
5.486e-03	-5.21	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	50	CLU
5.505e-03	-5.20	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	7	16828	49	PARD3,KALRN,LRP1B,PLCB1,NRG3,TSHZ2,MACF1
5.519e-03	-5.20	histone H3T6 kinase activity	molecular function	GO:0035403	2	1	18094	50	PRKCA
5.519e-03	-5.20	calcium,diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004698	2	1	18094	50	PRKCA
5.519e-03	-5.20	neutral L-amino acid secondary active transmembrane transporter activity	molecular function	GO:0005294	2	1	18094	50	SLC7A11
5.519e-03	-5.20	apolipoprotein A-I receptor activity	molecular function	GO:0034188	2	1	18094	50	ABCA1
5.519e-03	-5.20	heparanase activity	molecular function	GO:0030305	2	1	18094	50	HPSE2
5.547e-03	-5.19	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	50	FYN,BMPR1B,NTRK2
5.662e-03	-5.17	cyclic nucleotide metabolic process	biological process	GO:0009187	41	2	18204	50	RORA,ADCY2
5.665e-03	-5.17	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	5	10285	33	FYN,AHCYL1,ADCY2,PRKCA,NRG3
5.696e-03	-5.17	ARHGAP32 (Rho GTPase activating protein 32)	protein interactions	9743	141	3	19454	50	NTRK2,PARD3,FYN
5.697e-03	-5.17	amino acid transport	biological process	GO:0006865	132	3	18204	50	SLC7A11,SLC1A2,NTRK2
5.717e-03	-5.16	SH2D1A (SH2 domain containing 1A)	protein interactions	4068	44	2	19454	50	FYN,LRP1B
5.739e-03	-5.16	-	gene3d domains	1.20.58.60	35	2	14470	47	KALRN,MACF1
5.771e-03	-5.15	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	49	16828	49	ARHGEF4,GPC5,CTNND2,RFX4,CLU,FMN2,PTPRZ1,FYN,DTNA,ADCY2,SORBS1,NRG3,MSI2,NEBL,RORA,NRCAM,GLIS3,CNTN1,SLC7A11,ABCA1,SLC1A2,PRKCA,LSAMP,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,TRPS1,AQP4,NPAS3,BMPR1B,EYA2,MAP3K5,PARD3,EFEMP1,RYR3,AHCYL1,GPM6A,DCLK2,SOX5,PARD3B,PLCB1,PITPNC1,HIF3A,ATP1A2,LRP1B,KALRN,NTRK2
5.778e-03	-5.15	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	49	MACF1,TRPM3,CNTN1,GPC5,FMN2,PARD3,LRP1B,SLC1A2
5.778e-03	-5.15	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	49	LRP1B,PARD3,FMN2,SLC1A2,MACF1,TRPM3,CNTN1,GPC5
5.817e-03	-5.15	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	50	ATP1A2,PLCB1,RYR3
5.857e-03	-5.14	ankle	COSMIC cancer mutations	ankle	398	5	16828	49	TSHZ2,PARD3,NRG3,KALRN,PLCB1
5.935e-03	-5.13	Schwann cell development	biological process	GO:0014044	42	2	18204	50	PARD3,NTRK2
6.005e-03	-5.12	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	50	SLC7A11,SLC1A2
6.035e-03	-5.11	Ig-like_dom	interpro domains	IPR007110	432	5	18521	50	KALRN,NTRK2,CNTN1,LSAMP,NRCAM
6.123e-03	-5.10	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	19	16828	49	MAP3K5,KALRN,PRKCA,NTRK2,RORA,HIF3A,CNTN1,PLCB1,TRPS1,SOX5,DCLK2,BMPR1B,PITPNC1,FYN,PTPRZ1,ARHGEF4,MSI2,CTNND2,TSHZ2
6.136e-03	-5.09	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	5	10285	33	ADCY2,AHCYL1,FYN,NRG3,PRKCA
6.213e-03	-5.08	positive regulation of myoblast differentiation	biological process	GO:0045663	43	2	18204	50	MAP3K5,PLCB1
6.234e-03	-5.08	DKK2 (dickkopf WNT signaling pathway inhibitor 2)	protein interactions	27123	46	2	19454	50	LRP1B,AHCYL1
6.253e-03	-5.07	SPEC	smart domains	SM00150	29	2	9717	40	KALRN,MACF1
6.257e-03	-5.07	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	7	16828	49	BMPR1B,FYN,NTRK2,PRKCA,MAP3K5,LRP1B,DCLK2
6.257e-03	-5.07	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	7	16828	49	NTRK2,PRKCA,FYN,BMPR1B,LRP1B,DCLK2,MAP3K5
6.266e-03	-5.07	response to nitrogen compound	biological process	GO:1901698	1021	8	18204	50	SORBS1,AHCYL1,PLCB1,MAP3K5,FYN,SLC1A2,ABCA1,RYR3
6.286e-03	-5.07	tau protein binding	molecular function	GO:0048156	43	2	18094	50	FYN,CLU
6.291e-03	-5.07	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	50	TRPM3,GPM6A,RYR3
6.347e-03	-5.06	regulation of multicellular organismal development	biological process	GO:2000026	1484	10	18204	50	BMPR1B,PARD3,TRPS1,PRKCA,PLCB1,EFEMP1,MACF1,PTPRZ1,SOX5,NTRK2
6.348e-03	-5.06	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	4	19454	50	NEBL,PARD3,SORBS1,FMN2
6.372e-03	-5.06	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	39	16828	49	RYR3,MAP3K5,PARD3,ADCY2,EFEMP1,EYA2,PTPRZ1,FYN,FMN2,RFX4,NPAS3,TSHZ2,CTNND2,TRPM3,MACF1,ABLIM1,ARHGEF4,HPSE2,GPC5,PRKCA,NTRK2,LSAMP,KALRN,ATP1A2,LRP1B,ABCA1,SLC1A2,GLIS3,HIF3A,SLC7A11,CNTN1,RORA,PARD3B,SOX5,PLCB1,NEBL,MSI2,NRG3,AHCYL1
6.372e-03	-5.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	39	16828	49	PTPRZ1,FYN,FMN2,RFX4,NPAS3,TSHZ2,CTNND2,TRPM3,MACF1,ARHGEF4,ABLIM1,HPSE2,GPC5,RYR3,ADCY2,PARD3,MAP3K5,EFEMP1,EYA2,PARD3B,SOX5,NEBL,PLCB1,MSI2,NRG3,AHCYL1,PRKCA,LSAMP,NTRK2,ABCA1,LRP1B,ATP1A2,KALRN,SLC1A2,GLIS3,SLC7A11,HIF3A,CNTN1,RORA
6.383e-03	-5.05	rhythmic process	biological process	GO:0048511	270	4	18204	50	NTRK2,RORA,BMPR1B,MAPK10
6.398e-03	-5.05	pleura	COSMIC cancer mutations	pleura	4914	23	16828	49	MAP3K5,ARHGEF4,CTNND2,TSHZ2,FMN2,TRPS1,CLU,BMPR1B,FYN,PTPRZ1,RORA,HIF3A,CNTN1,KALRN,LRP1B,PRKCA,NTRK2,MSI2,NEBL,PLCB1,SOX5,DCLK2,PITPNC1
6.425e-03	-5.05	CEP128 (centrosomal protein 128)	protein interactions	145508	289	4	19454	50	AHCYL1,NEBL,ABLIM1,SORBS1
6.486e-03	-5.04	-	gene3d domains	6.20.350.10	2	1	14470	47	RYR3
6.488e-03	-5.04	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	5	10285	33	AHCYL1,ADCY2,FYN,PRKCA,NRG3
6.492e-03	-5.04	Ig_3	pfam domains	PF13927	141	3	17795	48	LSAMP,NRCAM,CNTN1
6.498e-03	-5.04	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	50	SLC1A2,SORBS1
6.498e-03	-5.04	neuron projection organization	biological process	GO:0106027	44	2	18204	50	CTNND2,FYN
6.500e-03	-5.04	SPHK1 (sphingosine kinase 1)	protein interactions	8877	47	2	19454	50	CTNND2,FYN
6.535e-03	-5.03	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	ko04933	99	3	7161	28	PRKCA,MAPK10,PLCB1
6.535e-03	-5.03	AGE-RAGE signaling pathway in diabetic complications	KEGG pathways	hsa04933	99	3	7161	28	PLCB1,MAPK10,PRKCA
6.549e-03	-5.03	lung-carcinoma-undifferentiated_carcinoma	COSMIC cancer mutations	lung-carcinoma-undifferentiated_carcinoma	1408	10	16828	49	MAP3K5,ABCA1,BMPR1B,FYN,NTRK2,PRKCA,EYA2,MSI2,NRG3,CNTN1
6.591e-03	-5.02	metal ion binding	molecular function	GO:0046872	4239	20	18094	50	FYN,RORA,RYR3,DTNA,GLIS3,PLCB1,ADCY2,MAP3K5,TSHZ2,ABLIM1,EFEMP1,KALRN,MACF1,PRKCA,EYA2,TRPS1,ATP1A2,BMPR1B,LRP1B,SLC1A2
6.599e-03	-5.02	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	9	19454	50	FYN,LSAMP,MSI2,SOX5,TRPS1,MACF1,CLU,GLIS3,AHCYL1
6.634e-03	-5.02	CDC25A (cell division cycle 25A)	protein interactions	993	149	3	19454	50	SOX5,MAP3K5,AHCYL1
6.670e-03	-5.01	blood vessel morphogenesis	biological process	GO:0048514	435	5	18204	50	HIF3A,RORA,NTRK2,PRKCA,NRCAM
6.772e-03	-4.99	PAM (peptidylglycine alpha-amidating monooxygenase)	protein interactions	5066	48	2	19454	50	PRKCA,KALRN
6.774e-03	-4.99	actin binding	molecular function	GO:0003779	434	5	18094	50	MACF1,NEBL,ABLIM1,SORBS1,FMN2
6.788e-03	-4.99	lamellipodium organization	biological process	GO:0097581	45	2	18204	50	ABLIM1,ARHGEF4
6.869e-03	-4.98	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME pathways	R-HSA-983695	39	2	10285	33	FYN,AHCYL1
6.870e-03	-4.98	uveal_tract	COSMIC cancer mutations	uveal_tract	587	6	16828	49	ARHGEF4,TRPM3,MACF1,CTNND2,KALRN,ADCY2
6.875e-03	-4.98	transmembrane transport	biological process	GO:0055085	1264	9	18204	50	ABCA1,RYR3,SLC1A2,SLC7A11,PLCB1,TRPM3,GPM6A,AQP4,ATP1A2
6.878e-03	-4.98	undifferentiated_carcinoma	COSMIC cancer mutations	undifferentiated_carcinoma	1418	10	16828	49	MSI2,NRG3,EYA2,CNTN1,MAP3K5,ABCA1,PRKCA,NTRK2,BMPR1B,FYN
6.881e-03	-4.98	MED21 (mediator complex subunit 21)	protein interactions	9412	151	3	19454	50	CNTN1,FYN,ABLIM1
6.907e-03	-4.98	Melanogenesis	KEGG pathways	hsa04916	101	3	7161	28	PLCB1,PRKCA,ADCY2
6.907e-03	-4.98	Melanogenesis	KEGG pathways	ko04916	101	3	7161	28	PLCB1,ADCY2,PRKCA
6.969e-03	-4.97	response to acid chemical	biological process	GO:0001101	142	3	18204	50	NTRK2,FYN,SLC1A2
6.997e-03	-4.96	femur	COSMIC cancer mutations	femur	1197	9	16828	49	RYR3,PTPRZ1,ADCY2,FMN2,LRP1B,ABCA1,NRG3,HPSE2,GPC5
7.007e-03	-4.96	STMN1 (stathmin 1)	protein interactions	3925	152	3	19454	50	PRKCA,AHCYL1,DTNA
7.036e-03	-4.96	phosphatidylinositol binding	molecular function	GO:0035091	276	4	18094	50	PLCB1,PARD3,PARD3B,PITPNC1
7.084e-03	-4.95	regulation of myelination	biological process	GO:0031641	46	2	18204	50	PARD3,PTPRZ1
7.085e-03	-4.95	protein tyrosine kinase activity	molecular function	GO:0004713	142	3	18094	50	NTRK2,FYN,EFEMP1
7.097e-03	-4.95	apical junction complex	cellular component	GO:0043296	150	3	19108	50	PARD3B,SORBS1,PARD3
7.119e-03	-4.94	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	4	16828	49	SLC1A2,ABCA1,SOX5,RYR3
7.191e-03	-4.93	regulation of neuron projection development	biological process	GO:0010975	443	5	18204	50	CNTN1,MACF1,FYN,NTRK2,NRCAM
7.203e-03	-4.93	RHOF (ras homolog family member F, filopodia associated)	protein interactions	54509	671	6	19454	50	MACF1,SLC7A11,AHCYL1,PARD3,FYN,FMN2
7.257e-03	-4.93	FORMIN	prints domains	PR00828	2	1	5227	19	FMN2
7.263e-03	-4.92	NMT1 (N-myristoyltransferase 1)	protein interactions	4836	154	3	19454	50	ABLIM1,FYN,DTNA
7.266e-03	-4.92	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	6	16828	49	LRP1B,TRPS1,MAP3K5,MACF1,CTNND2,ARHGEF4
7.275e-03	-4.92	small molecule binding	molecular function	GO:0036094	6197	26	18094	50	MAP3K5,FYN,RORA,DTNA,ATP1A2,SLC1A2,LRP1B,KALRN,DCLK2,PRKCA,TRPS1,GLIS3,PLCB1,ADCY2,TSHZ2,ABLIM1,PITPNC1,PARD3,RYR3,NTRK2,ABCA1,BMPR1B,MACF1,EFEMP1,EYA2,MAPK10
7.304e-03	-4.92	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	5	18094	50	SLC1A2,RYR3,GPM6A,ATP1A2,TRPM3
7.312e-03	-4.92	metal ion transport	biological process	GO:0030001	630	6	18204	50	FYN,PLCB1,ATP1A2,TRPM3,GPM6A,RYR3
7.325e-03	-4.92	regulation of signal transduction	biological process	GO:0009966	3114	16	18204	50	MACF1,CLU,CTNND2,ABCA1,NTRK2,KALRN,EYA2,PRKCA,ARHGEF4,FYN,GPC5,RORA,BMPR1B,SORBS1,PLCB1,MAP3K5
7.330e-03	-4.92	MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)	protein interactions	260425	50	2	19454	50	PARD3,NRCAM
7.379e-03	-4.91	T-Cell Receptor and Co-stimulatory Signaling	WikiPathways	WP2583	29	2	5310	24	PRKCA,FYN
7.386e-03	-4.91	Schwann cell differentiation	biological process	GO:0014037	47	2	18204	50	PARD3,NTRK2
7.404e-03	-4.91	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	4	16828	49	SOX5,LRP1B,EYA2,RYR3
7.420e-03	-4.90	regulation of apoptotic process	biological process	GO:0042981	1518	10	18204	50	CLU,PTPRZ1,SLC7A11,FMN2,NTRK2,EYA2,BMPR1B,PRKCA,FYN,MAP3K5
7.446e-03	-4.90	PAS domain	gene3d domains	3.30.450.20	40	2	14470	47	NPAS3,HIF3A
7.484e-03	-4.89	TRAF1 (TNF receptor associated factor 1)	protein interactions	7185	302	4	19454	50	GLIS3,NEBL,TSHZ2,MAP3K5
7.521e-03	-4.89	adult behavior	biological process	GO:0030534	146	3	18204	50	SLC1A2,SLC7A11,ATP1A2
7.525e-03	-4.89	CEP19 (centrosomal protein 19)	protein interactions	84984	156	3	19454	50	FMN2,PARD3,ABLIM1
7.617e-03	-4.88	PCDHGC3 (protocadherin gamma subfamily C, 3)	protein interactions	5098	51	2	19454	50	FYN,CNTN1
7.617e-03	-4.88	FAM171B (family with sequence similarity 171 member B)	protein interactions	165215	51	2	19454	50	PARD3,NTRK2
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.656e-03	-4.87	African trypanosomiasis	KEGG pathways	hsa05143	34	2	7161	28	PRKCA,PLCB1
7.656e-03	-4.87	African trypanosomiasis	KEGG pathways	ko05143	34	2	7161	28	PLCB1,PRKCA
7.691e-03	-4.87	Mta3 (metastasis associated 3)	protein interactions	116871	3	1	19454	50	FYN
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Gstm1 (glutathione S-transferase, mu 1)	protein interactions	14862	3	1	19454	50	MAP3K5
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Rb1cc1 (RB1-inducible coiled-coil 1)	protein interactions	12421	3	1	19454	50	MAP3K5
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Grm5 (glutamate metabotropic receptor 5)	protein interactions	24418	3	1	19454	50	PRKCA
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	Pde4d (phosphodiesterase 4D)	protein interactions	24627	3	1	19454	50	FYN
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.694e-03	-4.87	regulation of amyloid-beta formation	biological process	GO:1902003	48	2	18204	50	CLU,NTRK2
7.830e-03	-4.85	alphav-beta3 integrin-PKCalpha complex	cellular component	GO:0035866	3	1	19108	50	PRKCA
7.881e-03	-4.84	positive regulation of transport	biological process	GO:0051050	844	7	18204	50	CNTN1,SORBS1,AHCYL1,PLCB1,CLU,SLC1A2,ABCA1
7.909e-03	-4.84	AMHR2 (anti-Mullerian hormone receptor type 2)	protein interactions	269	52	2	19454	50	FYN,BMPR1B
7.928e-03	-4.84	APOA1 (apolipoprotein A1)	protein interactions	335	159	3	19454	50	ABCA1,CLU,MACF1
7.928e-03	-4.84	DTNBP1 (dystrobrevin binding protein 1)	protein interactions	84062	159	3	19454	50	KALRN,DTNA,MACF1
7.934e-03	-4.84	Netrin-1 signaling	REACTOME pathways	R-HSA-373752	42	2	10285	33	FYN,ABLIM1
7.934e-03	-4.84	EPHB-mediated forward signaling	REACTOME pathways	R-HSA-3928662	42	2	10285	33	KALRN,FYN
7.984e-03	-4.83	eye	COSMIC cancer mutations	eye	606	6	16828	49	CTNND2,MACF1,TRPM3,ARHGEF4,ADCY2,KALRN
8.007e-03	-4.83	ephrin receptor signaling pathway	biological process	GO:0048013	49	2	18204	50	KALRN,FYN
8.007e-03	-4.83	oligodendrocyte development	biological process	GO:0014003	49	2	18204	50	CLU,CNTN1
8.007e-03	-4.83	visual learning	biological process	GO:0008542	49	2	18204	50	SLC7A11,ATP1A2
8.021e-03	-4.83	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	9	16828	49	GPC5,TRPM3,CNTN1,CTNND2,ATP1A2,LRP1B,ADCY2,MAP3K5,PLCB1
8.065e-03	-4.82	FBF1 (Fas binding factor 1)	protein interactions	85302	160	3	19454	50	SORBS1,MAP3K5,ABLIM1
8.071e-03	-4.82	HIF-1	pfam domains	PF11413	3	1	17795	48	HIF3A
8.071e-03	-4.82	MAP3K_TRAF_bd	pfam domains	PF13281	3	1	17795	48	MAP3K5
8.071e-03	-4.82	RR_TM4-6	pfam domains	PF06459	3	1	17795	48	RYR3
8.071e-03	-4.82	PLC-beta_C	pfam domains	PF08703	3	1	17795	48	PLCB1
8.071e-03	-4.82	AdoHcyase_NAD	pfam domains	PF00670	3	1	17795	48	AHCYL1
8.071e-03	-4.82	RYDR_Jsol	pfam domains	PF21119	3	1	17795	48	RYR3
8.071e-03	-4.82	HisK-N-like	pfam domains	PF20302	3	1	17795	48	MAP3K5
8.071e-03	-4.82	RyR	pfam domains	PF02026	3	1	17795	48	RYR3
8.071e-03	-4.82	AdoHcyase	pfam domains	PF05221	3	1	17795	48	AHCYL1
8.071e-03	-4.82	Myelin_PLP	pfam domains	PF01275	3	1	17795	48	GPM6A
8.071e-03	-4.82	Sorb	pfam domains	PF02208	3	1	17795	48	SORBS1
8.071e-03	-4.82	LRRCT_2	pfam domains	PF16920	3	1	17795	48	NTRK2
8.071e-03	-4.82	SR_plectin_7	pfam domains	PF21097	3	1	17795	48	MACF1
8.071e-03	-4.82	ASK_PH	pfam domains	PF19039	3	1	17795	48	MAP3K5
8.071e-03	-4.82	DRHyd-ASK	pfam domains	PF20309	3	1	17795	48	MAP3K5
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	S-Ado-L-homoCys_hydrolase_CS	interpro domains	IPR020082	3	1	18521	50	AHCYL1
8.078e-03	-4.82	Teashirt_fam	interpro domains	IPR027008	3	1	18521	50	TSHZ2
8.078e-03	-4.82	MAP3K_TRAF-bd	interpro domains	IPR025136	3	1	18521	50	MAP3K5
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	Adenosylhomocysteinase-like	interpro domains	IPR000043	3	1	18521	50	AHCYL1
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	Protein_kinase_C_a/b/g	interpro domains	IPR014375	3	1	18521	50	PRKCA
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	PLC-beta_C	interpro domains	IPR014815	3	1	18521	50	PLCB1
8.078e-03	-4.82	DRHyd-ASK	interpro domains	IPR046872	3	1	18521	50	MAP3K5
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	50	HIF3A
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	MAP3K_PH	interpro domains	IPR043969	3	1	18521	50	MAP3K5
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	MAPK_JNK	interpro domains	IPR008351	3	1	18521	50	MAPK10
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	HisK-N-like	interpro domains	IPR046873	3	1	18521	50	MAP3K5
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	L_AA_transporter	interpro domains	IPR004760	3	1	18521	50	SLC7A11
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	Ado_hCys_hydrolase_NAD-bd	interpro domains	IPR015878	3	1	18521	50	AHCYL1
8.078e-03	-4.82	Adenosylhomocyst_ase-like_sf	interpro domains	IPR042172	3	1	18521	50	AHCYL1
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	DTNA,MACF1,SORBS1,PARD3
8.157e-03	-4.81	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	18	16828	49	NRG3,ABLIM1,GPC5,HPSE2,GPM6A,TSHZ2,MACF1,TRPM3,CTNND2,SOX5,FMN2,NEBL,PTPRZ1,LRP1B,ATP1A2,PARD3,ADCY2,RYR3
8.206e-03	-4.80	GNA12 (G protein subunit alpha 12)	protein interactions	2768	53	2	19454	50	MAP3K5,PRKCA
8.206e-03	-4.80	GRM1 (glutamate metabotropic receptor 1)	protein interactions	2911	53	2	19454	50	FYN,PRKCA
8.206e-03	-4.80	middle_third	COSMIC cancer mutations	middle_third	3533	18	16828	49	RYR3,LRP1B,ATP1A2,ADCY2,PARD3,MACF1,TRPM3,CTNND2,GPM6A,TSHZ2,GPC5,HPSE2,NRG3,ABLIM1,PTPRZ1,NEBL,SOX5,FMN2
8.216e-03	-4.80	CLb	smart domains	SM00030	2	1	9717	40	CLU
8.216e-03	-4.80	CLa	smart domains	SM00035	2	1	9717	40	CLU
8.218e-03	-4.80	regulation of retrograde trans-synaptic signaling by endocanabinoid	biological process	GO:0099178	3	1	18204	50	PLCB1
8.218e-03	-4.80	response to glycine	biological process	GO:1905429	3	1	18204	50	FYN
8.218e-03	-4.80	mammary placode formation	biological process	GO:0060596	3	1	18204	50	NRG3
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.218e-03	-4.80	regulation of dense core granule biogenesis	biological process	GO:2000705	3	1	18204	50	PRKCA
8.218e-03	-4.80	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	50	FMN2
8.218e-03	-4.80	regulation of glutamate metabolic process	biological process	GO:2000211	3	1	18204	50	SLC7A11
8.218e-03	-4.80	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	50	FMN2
8.218e-03	-4.80	cellular response to ionomycin	biological process	GO:1904637	3	1	18204	50	PLCB1
8.218e-03	-4.80	response to ionomycin	biological process	GO:1904636	3	1	18204	50	PLCB1
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.218e-03	-4.80	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	50	CLU
8.218e-03	-4.80	negative regulation of hydrogen peroxide biosynthetic process	biological process	GO:0010730	3	1	18204	50	FYN
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.218e-03	-4.80	immune complex clearance	biological process	GO:0002434	3	1	18204	50	CLU
8.218e-03	-4.80	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	50	NTRK2
8.218e-03	-4.80	negative regulation of ferroptosis	biological process	GO:0110076	3	1	18204	50	SLC7A11
8.218e-03	-4.80	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	50	NEBL
8.218e-03	-4.80	response to vitamin B3	biological process	GO:0033552	3	1	18204	50	ABCA1
8.218e-03	-4.80	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	50	FMN2
8.268e-03	-4.80	adenosylhomocysteinase activity	molecular function	GO:0004013	3	1	18094	50	AHCYL1
8.268e-03	-4.80	sulfur-containing amino acid secondary active transmembrane transporter activity	molecular function	GO:1901680	3	1	18094	50	SLC7A11
8.268e-03	-4.80	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	50	SLC1A2
8.268e-03	-4.80	epidermal growth factor receptor activity	molecular function	GO:0005006	3	1	18094	50	EFEMP1
8.268e-03	-4.80	apolipoprotein receptor activity	molecular function	GO:0030226	3	1	18094	50	ABCA1
8.268e-03	-4.80	hydrolase activity, acting on carbon-sulfur bonds	molecular function	GO:0046508	3	1	18094	50	AHCYL1
8.268e-03	-4.80	histone phosphatase activity	molecular function	GO:0140789	3	1	18094	50	EYA2
8.268e-03	-4.80	JUN kinase activity	molecular function	GO:0004705	3	1	18094	50	MAPK10
8.268e-03	-4.80	histone H2AXY142 phosphatase activity	molecular function	GO:0140793	3	1	18094	50	EYA2
8.304e-03	-4.79	Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME pathways	R-HSA-432040	43	2	10285	33	AQP4,ADCY2
8.329e-03	-4.79	response to chemical	biological process	GO:0042221	3743	18	18204	50	NRG3,FYN,ADCY2,PRKCA,AHCYL1,AQP4,NTRK2,SLC1A2,ABCA1,RYR3,CLU,MAP3K5,PLCB1,SORBS1,ATP1A2,RORA,FMN2,SLC7A11
8.343e-03	-4.79	CCDC57 (coiled-coil domain containing 57)	protein interactions	284001	162	3	19454	50	TSHZ2,ABLIM1,DCLK2
8.343e-03	-4.79	DSCAM (DS cell adhesion molecule)	protein interactions	1826	162	3	19454	50	MACF1,CLU,KALRN
8.358e-03	-4.78	neck	COSMIC cancer mutations	neck	1231	9	16828	49	ATP1A2,LRP1B,ADCY2,MAP3K5,PLCB1,GPC5,TRPM3,CNTN1,CTNND2
8.373e-03	-4.78	PRKCI (protein kinase C iota)	protein interactions	5584	312	4	19454	50	NTRK2,PRKCA,PARD3,FYN
8.440e-03	-4.77	Fc Epsilon Receptor I Signaling in Mast Cells	SMPDB pathways	SMP0000358	34	2	1369	6	FYN,PRKCA
8.469e-03	-4.77	Rap1 signaling pathway	KEGG pathways	ko04015	210	4	7161	28	ADCY2,PRKCA,PARD3,PLCB1
8.469e-03	-4.77	Rap1 signaling pathway	KEGG pathways	hsa04015	210	4	7161	28	PLCB1,PARD3,PRKCA,ADCY2
8.484e-03	-4.77	DLG4 (discs large MAGUK scaffold protein 4)	protein interactions	1742	163	3	19454	50	PRKCA,CLU,FYN
8.523e-03	-4.77	HSP90AA1 (heat shock protein 90 alpha family class A member 1)	protein interactions	3320	1150	8	19454	50	DCLK2,FYN,HIF3A,MAP3K5,AHCYL1,PRKCA,NTRK2,CLU
8.523e-03	-4.77	YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)	protein interactions	7531	1150	8	19454	50	DCLK2,PARD3B,PARD3,ARHGEF4,ABLIM1,MACF1,SORBS1,MAP3K5
8.554e-03	-4.76	SNCA (synuclein alpha)	protein interactions	6622	696	6	19454	50	GPM6A,FYN,MACF1,CLU,NTRK2,PLCB1
8.603e-03	-4.76	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	48	2	16828	49	PARD3,RYR3
8.651e-03	-4.75	response to nicotine	biological process	GO:0035094	51	2	18204	50	SLC7A11,ATP1A2
8.772e-03	-4.74	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	5	16828	49	FYN,BMPR1B,NTRK2,PRKCA,MAP3K5
8.814e-03	-4.73	GJB7 (gap junction protein beta 7)	protein interactions	375519	55	2	19454	50	CNTN1,FYN
8.841e-03	-4.73	neuronal cell body	cellular component	GO:0043025	489	5	19108	50	GPM6A,ATP1A2,CTNND2,FYN,BMPR1B
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	ATP1A2,NEBL,ABLIM1
8.935e-03	-4.72	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	4	10285	33	PRKCA,NRG3,FYN,AHCYL1
9.013e-03	-4.71	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	50	GPM6A,BMPR1B,NTRK2
9.024e-03	-4.71	Aldosterone-regulated sodium reabsorption	KEGG pathways	ko04960	37	2	7161	28	PRKCA,ATP1A2
9.024e-03	-4.71	Aldosterone-regulated sodium reabsorption	KEGG pathways	hsa04960	37	2	7161	28	ATP1A2,PRKCA
9.032e-03	-4.71	lipid binding	molecular function	GO:0008289	861	7	18094	50	ABCA1,PLCB1,ATP1A2,PARD3B,PARD3,RORA,PITPNC1
9.061e-03	-4.70	purine ribonucleoside triphosphate binding	molecular function	GO:0035639	1804	11	18094	50	ADCY2,ATP1A2,ABCA1,MAP3K5,BMPR1B,KALRN,FYN,PRKCA,DCLK2,MAPK10,NTRK2
9.086e-03	-4.70	cell-cell adhesion mediator activity	molecular function	GO:0098632	52	2	18094	50	CNTN1,NRCAM
9.125e-03	-4.70	L1CAM (L1 cell adhesion molecule)	protein interactions	3897	56	2	19454	50	CNTN1,GPM6A
9.212e-03	-4.69	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	45	16828	49	PARD3B,DCLK2,SOX5,PLCB1,GPM6A,AHCYL1,NTRK2,LRP1B,ATP1A2,KALRN,HIF3A,BMPR1B,TRPS1,NPAS3,AQP4,TSHZ2,MACF1,TRPM3,HPSE2,RYR3,MAP3K5,PARD3,EFEMP1,EYA2,NEBL,NRG3,PRKCA,LSAMP,ABCA1,SLC1A2,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,PTPRZ1,FYN,FMN2,CLU,RFX4,CTNND2,ARHGEF4,GPC5,SORBS1,ADCY2
9.231e-03	-4.69	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	4	19454	50	MACF1,DTNA,SORBS1,PRKCA
9.292e-03	-4.68	regulation of programmed cell death	biological process	GO:0043067	1569	10	18204	50	EYA2,BMPR1B,MAP3K5,FYN,PRKCA,SLC7A11,PTPRZ1,CLU,NTRK2,FMN2
9.318e-03	-4.68	neutral amino acid transport	biological process	GO:0015804	53	2	18204	50	SLC1A2,SLC7A11
9.361e-03	-4.67	DLG5 (discs large MAGUK scaffold protein 5)	protein interactions	9231	169	3	19454	50	NTRK2,ABCA1,PARD3
9.442e-03	-4.66	PRKCQ (protein kinase C theta)	protein interactions	5588	57	2	19454	50	FYN,PRKCA
9.485e-03	-4.66	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	6	18204	50	NTRK2,MACF1,FYN,NRCAM,CNTN1,GPM6A
9.491e-03	-4.66	Endothelin Pathways	WikiPathways	WP2197	33	2	5310	24	PLCB1,PRKCA
9.521e-03	-4.65	RHOU (ras homolog family member U)	protein interactions	58480	507	5	19454	50	SLC7A11,AHCYL1,FYN,PARD3,MACF1
9.659e-03	-4.64	glutathione metabolic process	biological process	GO:0006749	54	2	18204	50	SLC1A2,SLC7A11
9.669e-03	-4.64	presynaptic membrane	cellular component	GO:0042734	168	3	19108	50	CNTN1,SLC1A2,GPM6A
9.713e-03	-4.63	Adenosylhomocysteinase-like	gene3d domains	3.40.50.1480	3	1	14470	47	AHCYL1
9.713e-03	-4.63	-	gene3d domains	1.10.490.160	3	1	14470	47	RYR3
9.731e-03	-4.63	PXN (paxillin)	protein interactions	5829	326	4	19454	50	ABLIM1,FYN,SORBS1,MACF1
9.763e-03	-4.63	GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B)	protein interactions	2904	58	2	19454	50	FYN,PRKCA
9.763e-03	-4.63	SNAP25 (synaptosome associated protein 25)	protein interactions	6616	58	2	19454	50	GPM6A,PRKCA
9.770e-03	-4.63	regulation of response to stimulus	biological process	GO:0048583	4104	19	18204	50	FMN2,SLC7A11,GPC5,MAP3K5,PLCB1,SORBS1,MAPK10,BMPR1B,RORA,KALRN,NTRK2,ABCA1,CTNND2,MACF1,CLU,FYN,PRKCA,ARHGEF4,EYA2
9.819e-03	-4.62	positive regulation of neuron projection development	biological process	GO:0010976	161	3	18204	50	FYN,NTRK2,CNTN1
9.833e-03	-4.62	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	4	19454	50	PARD3,EYA2,SORBS1,DTNA
9.847e-03	-4.62	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	26	16828	49	DTNA,PARD3,ADCY2,MAP3K5,RYR3,ABLIM1,TSHZ2,CTNND2,TRPM3,MACF1,NPAS3,PTPRZ1,NRCAM,RORA,GLIS3,SLC7A11,CNTN1,KALRN,ATP1A2,ABCA1,LRP1B,NTRK2,NRG3,SOX5,DCLK2,NEBL
1.001e-02	-4.60	intermembrane lipid transfer	biological process	GO:0120009	55	2	18204	50	ABCA1,PITPNC1
1.001e-02	-4.60	regulation of amyloid precursor protein catabolic process	biological process	GO:1902991	55	2	18204	50	CLU,NTRK2
1.001e-02	-4.60	establishment or maintenance of epithelial cell apical/basal polarity	biological process	GO:0045197	55	2	18204	50	PARD3B,PARD3
1.001e-02	-4.60	Fc receptor signaling pathway	biological process	GO:0038093	55	2	18204	50	FYN,MAPK10
1.002e-02	-4.60	Znf_NHR/GATA	interpro domains	IPR013088	56	2	18521	50	RORA,TRPS1
1.009e-02	-4.60	ANKRD36B (ankyrin repeat domain 36B)	protein interactions	57730	59	2	19454	50	LRP1B,AHCYL1
1.009e-02	-4.60	HTATIP2 (HIV-1 Tat interactive protein 2)	protein interactions	10553	59	2	19454	50	PRKCA,PITPNC1
1.009e-02	-4.60	VEGFA (vascular endothelial growth factor A)	protein interactions	7422	59	2	19454	50	CLU,PTPRZ1
1.010e-02	-4.59	Thyroid hormone signaling pathway	KEGG pathways	hsa04919	116	3	7161	28	PLCB1,PRKCA,ATP1A2
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	IGKV@ (immunoglobulin kappa variable cluster)	protein interactions	3519	4	1	19454	50	LRP1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	AVPR1A (arginine vasopressin receptor 1A)	protein interactions	552	4	1	19454	50	PRKCA
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Pick1 (protein interacting with PRKCA 1)	protein interactions	84591	4	1	19454	50	PRKCA
1.024e-02	-4.58	LOC442497 (uncharacterized LOC442497)	protein interactions	442497	4	1	19454	50	EYA2
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	pleura-mesothelioma	COSMIC cancer mutations	pleura-mesothelioma	4189	20	16828	49	PITPNC1,BMPR1B,FYN,PTPRZ1,PLCB1,CLU,TRPS1,SOX5,DCLK2,CTNND2,TSHZ2,ARHGEF4,MSI2,PRKCA,NTRK2,MAP3K5,KALRN,HIF3A,CNTN1,RORA
1.027e-02	-4.58	G alpha (z) signalling events	REACTOME pathways	R-HSA-418597	48	2	10285	33	ADCY2,PRKCA
1.029e-02	-4.58	LRP1 (LDL receptor related protein 1)	protein interactions	4035	175	3	19454	50	CLU,LRP1B,PRKCA
1.031e-02	-4.58	dendritic spine	cellular component	GO:0043197	172	3	19108	50	NTRK2,ATP1A2,GPM6A
1.032e-02	-4.57	negative regulation of neuron apoptotic process	biological process	GO:0043524	164	3	18204	50	NTRK2,CLU,PTPRZ1
1.036e-02	-4.57	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	50	RYR3,PLCB1
1.039e-02	-4.57	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	33	RYR3,AHCYL1,ATP1A2
1.040e-02	-4.57	regulation of transmembrane transport	biological process	GO:0034762	485	5	18204	50	SLC1A2,FYN,ATP1A2,AHCYL1,SORBS1
1.042e-02	-4.56	F11R (F11 receptor)	protein interactions	50848	60	2	19454	50	PRKCA,PARD3
1.042e-02	-4.56	BTN2A1 (butyrophilin subfamily 2 member A1)	protein interactions	11120	60	2	19454	50	PLCB1,FMN2
1.042e-02	-4.56	SNTB1 (syntrophin beta 1)	protein interactions	6641	60	2	19454	50	ABCA1,DTNA
1.043e-02	-4.56	internode region of axon	cellular component	GO:0033269	4	1	19108	50	PARD3
1.043e-02	-4.56	IRE1-TRAF2-ASK1 complex	cellular component	GO:1990604	4	1	19108	50	MAP3K5
1.048e-02	-4.56	lipid transfer activity	molecular function	GO:0120013	56	2	18094	50	PITPNC1,ABCA1
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	SLC1A2,ATP1A2,SLC7A11
1.050e-02	-4.56	response to light stimulus	biological process	GO:0009416	312	4	18204	50	MAPK10,ATP1A2,SLC7A11,SLC1A2
1.053e-02	-4.55	transmembrane transporter activity	molecular function	GO:0022857	1110	8	18094	50	GPM6A,RYR3,AQP4,TRPM3,SLC7A11,SLC1A2,ATP1A2,ABCA1
1.063e-02	-4.54	neuron spine	cellular component	GO:0044309	174	3	19108	50	ATP1A2,NTRK2,GPM6A
1.066e-02	-4.54	regulation of cell projection organization	biological process	GO:0031344	683	6	18204	50	FYN,NRCAM,GPM6A,CNTN1,NTRK2,MACF1
1.067e-02	-4.54	Integrin-mediated Cell Adhesion	WikiPathways	WP185	103	3	5310	24	MAPK10,SORBS1,FYN
1.072e-02	-4.54	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	50	PLCB1,RYR3
1.073e-02	-4.53	cell-cell junction	cellular component	GO:0005911	513	5	19108	50	ATP1A2,CTNND2,PARD3B,SORBS1,PARD3
1.075e-02	-4.53	Spectrin_4	pfam domains	PF21020	4	1	17795	48	MACF1
1.075e-02	-4.53	PH_14	pfam domains	PF17787	4	1	17795	48	PLCB1
1.075e-02	-4.53	Bravo_FIGEY	pfam domains	PF13882	4	1	17795	48	NRCAM
1.075e-02	-4.53	AbLIM_anchor	pfam domains	PF16182	4	1	17795	48	ABLIM1
1.075e-02	-4.53	Spectrin_3	pfam domains	PF21019	4	1	17795	48	MACF1
1.075e-02	-4.53	TRPM_tetra	pfam domains	PF16519	4	1	17795	48	TRPM3
1.075e-02	-4.53	Spectrin_2	pfam domains	PF18373	4	1	17795	48	MACF1
1.075e-02	-4.53	Nebulin	pfam domains	PF00880	4	1	17795	48	NEBL
1.076e-02	-4.53	EYA_dom_metazoan	interpro domains	IPR042577	4	1	18521	50	EYA2
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	EYA_dom_sf	interpro domains	IPR038102	4	1	18521	50	EYA2
1.076e-02	-4.53	EYA_dom	interpro domains	IPR006545	4	1	18521	50	EYA2
1.076e-02	-4.53	PLC-beta	interpro domains	IPR016280	4	1	18521	50	PLCB1
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	EYA_fam	interpro domains	IPR028472	4	1	18521	50	EYA2
1.076e-02	-4.53	PLC-beta_PH	interpro domains	IPR037862	4	1	18521	50	PLCB1
1.076e-02	-4.53	Neurofascin/L1/NrCAM_C	interpro domains	IPR026966	4	1	18521	50	NRCAM
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	PLC-beta_C_sf	interpro domains	IPR042531	4	1	18521	50	PLCB1
1.076e-02	-4.53	MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3)	protein interactions	23162	61	2	19454	50	MAP3K5,MAPK10
1.080e-02	-4.53	ACTB (actin beta)	protein interactions	60	958	7	19454	50	DTNA,MACF1,SORBS1,NEBL,PRKCA,FMN2,ABLIM1
1.082e-02	-4.53	positive regulation of cellular component organization	biological process	GO:0051130	1122	8	18204	50	FYN,PLCB1,CNTN1,GPM6A,NTRK2,ABCA1,CLU,MACF1
1.083e-02	-4.53	Neurotrophin signaling pathway	KEGG pathways	hsa04722	119	3	7161	28	MAPK10,NTRK2,MAP3K5
1.083e-02	-4.53	Neurotrophin signaling pathway	KEGG pathways	ko04722	119	3	7161	28	MAPK10,MAP3K5,NTRK2
1.084e-02	-4.52	apoptotic signaling pathway	biological process	GO:0097190	315	4	18204	50	MAP3K5,PRKCA,EYA2,CLU
1.087e-02	-4.52	MYELINPLP	prints domains	PR00214	3	1	5227	19	GPM6A
1.087e-02	-4.52	JNKMAPKINASE	prints domains	PR01772	3	1	5227	19	MAPK10
1.087e-02	-4.52	RORNUCRECPTR	prints domains	PR01293	3	1	5227	19	RORA
1.087e-02	-4.52	RYANODINER	prints domains	PR00795	3	1	5227	19	RYR3
1.087e-02	-4.52	NTKRECEPTOR	prints domains	PR01939	3	1	5227	19	NTRK2
1.093e-02	-4.52	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	298	4	16828	49	CTNND2,FMN2,ATP1A2,LRP1B
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	50	BMPR1B
1.094e-02	-4.52	regulation of angiotensin-activated signaling pathway	biological process	GO:0110061	4	1	18204	50	PRKCA
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.094e-02	-4.52	regulation of high-density lipoprotein particle assembly	biological process	GO:0090107	4	1	18204	50	ABCA1
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.094e-02	-4.52	negative regulation of dendritic spine maintenance	biological process	GO:1902951	4	1	18204	50	FYN
1.094e-02	-4.52	response to fluoride	biological process	GO:1902617	4	1	18204	50	PLCB1
1.094e-02	-4.52	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	50	CLU
1.094e-02	-4.52	desmosome assembly	biological process	GO:0002159	4	1	18204	50	PRKCA
1.094e-02	-4.52	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	50	NTRK2
1.094e-02	-4.52	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	50	NTRK2
1.095e-02	-4.51	tat (Tat)	protein interactions	155871	1718	10	19454	50	PRKCA,PLCB1,AHCYL1,SLC7A11,BMPR1B,SORBS1,NRCAM,SLC1A2,RYR3,ADCY2
1.095e-02	-4.51	import into cell	biological process	GO:0098657	687	6	18204	50	FYN,ATP1A2,LRP1B,ABCA1,SLC1A2,SLC7A11
1.096e-02	-4.51	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	7	16828	49	BMPR1B,FYN,NTRK2,PRKCA,PTPRZ1,MAP3K5,DCLK2
1.096e-02	-4.51	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	7	16828	49	MAP3K5,DCLK2,BMPR1B,FYN,NTRK2,PTPRZ1,PRKCA
1.097e-02	-4.51	HSPA5 (heat shock protein family A (Hsp70) member 5)	protein interactions	3309	1455	9	19454	50	EFEMP1,PARD3,FYN,GPC5,CLU,HPSE2,AHCYL1,LRP1B,DTNA
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	BMPR1B,TRPS1,NPAS3,AQP4,TSHZ2,MACF1,TRPM3,ABLIM1,HPSE2,RYR3,PARD3,MAP3K5,EFEMP1,EYA2,PITPNC1,SOX5,DCLK2,PARD3B,PLCB1,GPM6A,AHCYL1,NTRK2,ATP1A2,KALRN,LRP1B,HIF3A,PTPRZ1,FYN,RFX4,CLU,FMN2,CTNND2,ARHGEF4,GPC5,SORBS1,ADCY2,DTNA,NEBL,MSI2,NRG3,LSAMP,PRKCA,ABCA1,SLC1A2,GLIS3,CNTN1,SLC7A11,RORA,NRCAM
1.101e-02	-4.51	sphingolipid floppase activity	molecular function	GO:0046623	4	1	18094	50	ABCA1
1.101e-02	-4.51	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	50	RYR3
1.101e-02	-4.51	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	50	NTRK2
1.101e-02	-4.51	phospholipid binding	molecular function	GO:0005543	489	5	18094	50	PITPNC1,ABCA1,PARD3B,PLCB1,PARD3
1.104e-02	-4.51	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	45	GPM6A
1.104e-02	-4.51	ADOHCYASE_2	prosite domains	PS00739	3	1	12186	45	AHCYL1
1.104e-02	-4.51	ADOHCYASE_1	prosite domains	PS00738	3	1	12186	45	AHCYL1
1.104e-02	-4.51	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	45	GPM6A
1.104e-02	-4.51	SOHO	prosite domains	PS50831	3	1	12186	45	SORBS1
1.108e-02	-4.50	JNK cascade	biological process	GO:0007254	58	2	18204	50	MAPK10,MAP3K5
1.110e-02	-4.50	EPHA4 (EPH receptor A4)	protein interactions	2043	180	3	19454	50	AHCYL1,FYN,PARD3
1.110e-02	-4.50	MYOD1 (myogenic differentiation 1)	protein interactions	4654	180	3	19454	50	PRKCA,RORA,TRPS1
1.120e-02	-4.49	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME pathways	R-HSA-112314	146	3	10285	33	ADCY2,PLCB1,PRKCA
1.133e-02	-4.48	Vascular smooth muscle contraction	KEGG pathways	hsa04270	121	3	7161	28	PLCB1,ADCY2,PRKCA
1.133e-02	-4.48	Vascular smooth muscle contraction	KEGG pathways	ko04270	121	3	7161	28	PRKCA,ADCY2,PLCB1
1.138e-02	-4.48	head_neck	COSMIC cancer mutations	head_neck	15361	49	16828	49	EFEMP1,PARD3,MAP3K5,RYR3,EYA2,NPAS3,AQP4,TRPS1,BMPR1B,HPSE2,ABLIM1,TRPM3,MACF1,TSHZ2,LRP1B,KALRN,ATP1A2,NTRK2,HIF3A,PLCB1,DCLK2,SOX5,PARD3B,PITPNC1,AHCYL1,GPM6A,ADCY2,SORBS1,DTNA,RFX4,CLU,FMN2,FYN,PTPRZ1,GPC5,ARHGEF4,CTNND2,SLC1A2,ABCA1,LSAMP,PRKCA,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,NEBL,NRG3,MSI2
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.144e-02	-4.47	KCNA4 (potassium voltage-gated channel subfamily A member 4)	protein interactions	3739	63	2	19454	50	DTNA,FYN
1.145e-02	-4.47	establishment or maintenance of bipolar cell polarity	biological process	GO:0061245	59	2	18204	50	PARD3,PARD3B
1.145e-02	-4.47	establishment or maintenance of apical/basal cell polarity	biological process	GO:0035088	59	2	18204	50	PARD3,PARD3B
1.148e-02	-4.47	adrenal_cortical_adenoma	COSMIC cancer mutations	adrenal_cortical_adenoma	161	3	16828	49	ADCY2,FMN2,LRP1B
1.156e-02	-4.46	regulation of transport	biological process	GO:0051049	1621	10	18204	50	FYN,PLCB1,ATP1A2,AHCYL1,SORBS1,CNTN1,SLC1A2,ABCA1,SLC7A11,CLU
1.156e-02	-4.46	EF-hand	gene3d domains	1.10.238.10	272	4	14470	47	RYR3,MACF1,DTNA,PLCB1
1.158e-02	-4.46	sulfur compound transmembrane transporter activity	molecular function	GO:1901682	59	2	18094	50	SLC1A2,SLC7A11
1.161e-02	-4.46	MAPK9 (mitogen-activated protein kinase 9)	protein interactions	5601	183	3	19454	50	MACF1,MAPK10,CLU
1.165e-02	-4.45	leading edge membrane	cellular component	GO:0031256	180	3	19108	50	ARHGEF4,SLC1A2,MACF1
1.167e-02	-4.45	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	162	3	16828	49	RYR3,MACF1,FYN
1.177e-02	-4.44	purine ribonucleotide binding	molecular function	GO:0032555	1871	11	18094	50	ABCA1,ADCY2,ATP1A2,BMPR1B,MAP3K5,FYN,KALRN,DCLK2,PRKCA,NTRK2,MAPK10
1.182e-02	-4.44	protein homotetramerization	biological process	GO:0051289	60	2	18204	50	AQP4,RYR3
1.182e-02	-4.44	export across plasma membrane	biological process	GO:0140115	60	2	18204	50	ABCA1,ATP1A2
1.182e-02	-4.44	regulation of glucose import	biological process	GO:0046324	60	2	18204	50	SORBS1,SLC1A2
1.185e-02	-4.44	Platelet activation	KEGG pathways	hsa04611	123	3	7161	28	ADCY2,FYN,PLCB1
1.191e-02	-4.43	SLC3A2 (solute carrier family 3 member 2)	protein interactions	6520	346	4	19454	50	SLC7A11,EYA2,PARD3,SLC1A2
1.192e-02	-4.43	negative regulation of apoptotic process	biological process	GO:0043066	914	7	18204	50	EYA2,CLU,PTPRZ1,PRKCA,FMN2,FYN,NTRK2
1.192e-02	-4.43	regulation of cell size	biological process	GO:0008361	173	3	18204	50	AQP4,MACF1,NRCAM
1.195e-02	-4.43	ATP2B2 (ATPase plasma membrane Ca2+ transporting 2)	protein interactions	491	185	3	19454	50	GPM6A,CLU,PRKCA
1.196e-02	-4.43	perinuclear region of cytoplasm	cellular component	GO:0048471	735	6	19108	50	CLU,FYN,PRKCA,FMN2,ABCA1,NTRK2
1.198e-02	-4.42	Aquaporin-mediated transport	REACTOME pathways	R-HSA-445717	52	2	10285	33	AQP4,ADCY2
1.199e-02	-4.42	response to organonitrogen compound	biological process	GO:0010243	915	7	18204	50	SORBS1,AHCYL1,FYN,SLC1A2,ABCA1,PLCB1,RYR3
1.209e-02	-4.42	kidney	COSMIC cancer mutations	kidney	15380	49	16828	49	PTPRZ1,FYN,FMN2,CLU,RFX4,CTNND2,ARHGEF4,GPC5,ADCY2,SORBS1,DTNA,NEBL,MSI2,NRG3,LSAMP,PRKCA,ABCA1,SLC1A2,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,BMPR1B,TRPS1,AQP4,NPAS3,TSHZ2,MACF1,TRPM3,ABLIM1,HPSE2,RYR3,MAP3K5,PARD3,EFEMP1,EYA2,PITPNC1,PARD3B,SOX5,DCLK2,PLCB1,GPM6A,AHCYL1,NTRK2,LRP1B,ATP1A2,KALRN,HIF3A
1.215e-02	-4.41	PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)	protein interactions	5534	65	2	19454	50	MAP3K5,GPM6A
1.218e-02	-4.41	positive regulation of developmental process	biological process	GO:0051094	1385	9	18204	50	MAP3K5,NRCAM,PLCB1,PRKCA,BMPR1B,SOX5,NTRK2,PTPRZ1,MACF1
1.222e-02	-4.40	lung-carcinoma	COSMIC cancer mutations	lung-carcinoma	4255	20	16828	49	KALRN,MAP3K5,PRKCA,NTRK2,RORA,CNTN1,HIF3A,PLCB1,CLU,TRPS1,SOX5,DCLK2,FYN,BMPR1B,PITPNC1,PTPRZ1,MSI2,ARHGEF4,CTNND2,TSHZ2
1.230e-02	-4.40	AdoHcyase_NAD	smart domains	SM00997	3	1	9717	40	AHCYL1
1.230e-02	-4.40	AdoHcyase	smart domains	SM00996	3	1	9717	40	AHCYL1
1.230e-02	-4.40	Sorb	smart domains	SM00459	3	1	9717	40	SORBS1
1.230e-02	-4.40	PLP	smart domains	SM00002	3	1	9717	40	GPM6A
1.230e-02	-4.40	KLF5 (KLF transcription factor 5)	protein interactions	688	187	3	19454	50	PRKCA,CLU,TRPS1
1.240e-02	-4.39	cell migration	biological process	GO:0016477	921	7	18204	50	GPM6A,FYN,NRG3,NRCAM,GPC5,NTRK2,FMN2
1.246e-02	-4.38	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	24	SLC1A2,MAP3K5
1.250e-02	-4.38	GNG2 (G protein subunit gamma 2)	protein interactions	54331	66	2	19454	50	ADCY2,FYN
1.253e-02	-4.38	SH3_9	pfam domains	PF14604	63	2	17795	48	NEBL,SORBS1
1.255e-02	-4.38	Nephrin/Neph1 signaling in the kidney podocyte	Pathway Interaction DB	nephrin_neph1_pathway	26	2	2226	15	MAPK10,FYN
1.255e-02	-4.38	ribonucleotide binding	molecular function	GO:0032553	1888	11	18094	50	NTRK2,MAPK10,FYN,KALRN,DCLK2,PRKCA,BMPR1B,MAP3K5,ABCA1,ADCY2,ATP1A2
1.259e-02	-4.38	sulfur compound transport	biological process	GO:0072348	62	2	18204	50	SLC7A11,SLC1A2
1.262e-02	-4.37	CTBP2 (C-terminal binding protein 2)	protein interactions	1488	352	4	19454	50	MSI2,MAPK10,PLCB1,TRPS1
1.262e-02	-4.37	Ig-like_fold	interpro domains	IPR013783	721	6	18521	50	CNTN1,NRCAM,LSAMP,NTRK2,KALRN,PTPRZ1
1.266e-02	-4.37	RPS6KA2 (ribosomal protein S6 kinase A2)	protein interactions	6196	189	3	19454	50	AHCYL1,FYN,MACF1
1.266e-02	-4.37	peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	peripheral_T_cell_lymphoma_unspecified	167	3	16828	49	FYN,MACF1,RYR3
1.269e-02	-4.37	Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME pathways	R-HSA-881907	443	5	10285	33	FYN,PLCB1,KALRN,PRKCA,NRG3
1.273e-02	-4.36	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	50	NTRK2,EFEMP1
1.277e-02	-4.36	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	1	10285	33	SLC1A2
1.277e-02	-4.36	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	1	10285	33	SLC1A2
1.279e-02	-4.36	DLX3 (distal-less homeobox 3)	protein interactions	1747	5	1	19454	50	PRKCA
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	SUI2 (translation initiation factor eIF2 subunit alpha)	protein interactions	853463	5	1	19454	50	PRKCA
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	FAM135B (family with sequence similarity 135 member B)	protein interactions	51059	5	1	19454	50	FYN
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rnf166 (ring finger protein 166)	protein interactions	68718	5	1	19454	50	MAP3K5
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	CFHR3 (complement factor H related 3)	protein interactions	10878	5	1	19454	50	PRKCA
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2)	protein interactions	2570	5	1	19454	50	PRKCA
1.287e-02	-4.35	NR1H2 (nuclear receptor subfamily 1 group H member 2)	protein interactions	7376	67	2	19454	50	ABCA1,PRKCA
1.287e-02	-4.35	ZNF696 (zinc finger protein 696)	protein interactions	79943	67	2	19454	50	AHCYL1,EFEMP1
1.287e-02	-4.35	ARMC1 (armadillo repeat containing 1)	protein interactions	55156	67	2	19454	50	CNTN1,GPM6A
1.287e-02	-4.35	ADAM15 (ADAM metallopeptidase domain 15)	protein interactions	8751	67	2	19454	50	FYN,SORBS1
1.287e-02	-4.35	Heparan sulfate/heparin (HS-GAG) metabolism	REACTOME pathways	R-HSA-1638091	54	2	10285	33	HPSE2,GPC5
1.293e-02	-4.35	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	47	TRPM3
1.293e-02	-4.35	-	gene3d domains	3.40.50.12350	4	1	14470	47	EYA2
1.293e-02	-4.35	-	gene3d domains	2.30.29.240	4	1	14470	47	PLCB1
1.293e-02	-4.35	-	gene3d domains	1.20.58.1060	4	1	14470	47	MACF1
1.293e-02	-4.35	Phospholipase C beta, distal C-terminal domain	gene3d domains	1.20.1230.10	4	1	14470	47	PLCB1
1.302e-02	-4.34	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	50	CLU
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	AHCYL1,GPM6A,PARD3B,DCLK2,SOX5,PLCB1,PITPNC1,HIF3A,LRP1B,ATP1A2,KALRN,NTRK2,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,TRPS1,AQP4,NPAS3,BMPR1B,EYA2,MAP3K5,PARD3,EFEMP1,RYR3,NRG3,MSI2,NEBL,NRCAM,RORA,GLIS3,SLC7A11,CNTN1,ABCA1,SLC1A2,PRKCA,LSAMP,ARHGEF4,GPC5,CTNND2,FMN2,CLU,RFX4,PTPRZ1,FYN,SORBS1,ADCY2
1.310e-02	-4.34	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	5	16828	49	LRP1B,EYA2,RYR3,LSAMP,CNTN1
1.310e-02	-4.34	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	5	16828	49	LSAMP,RYR3,CNTN1,LRP1B,EYA2
1.320e-02	-4.33	HSP90B1 (heat shock protein 90 beta family member 1)	protein interactions	7184	550	5	19454	50	PRKCA,CLU,EFEMP1,DTNA,FYN
1.322e-02	-4.33	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	5	18204	50	GPM6A,CLU,ABCA1,PRKCA,NTRK2
1.323e-02	-4.33	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	4	19454	50	NEBL,PARD3,MACF1,SORBS1
1.324e-02	-4.32	CIB1 (calcium and integrin binding 1)	protein interactions	10519	68	2	19454	50	MAP3K5,GLIS3
1.324e-02	-4.32	PLCH1 (phospholipase C eta 1)	protein interactions	23007	68	2	19454	50	NTRK2,PARD3
1.332e-02	-4.32	human chr4q21.3	chromosome location	human chr4q21.3	7	1	26134	50	MAPK10
1.335e-02	-4.32	KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1)	protein interactions	10657	358	4	19454	50	ARHGEF4,EFEMP1,SORBS1,FYN
1.337e-02	-4.31	dendrite morphogenesis	biological process	GO:0048813	64	2	18204	50	CTNND2,FYN
1.337e-02	-4.31	cellular senescence	biological process	GO:0090398	64	2	18204	50	MAPK10,MAP3K5
1.337e-02	-4.31	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	50	FMN2,SORBS1
1.342e-02	-4.31	IP_trans	pfam domains	PF02121	5	1	17795	48	PITPNC1
1.342e-02	-4.31	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	6	18094	50	GPM6A,AQP4,RYR3,SLC1A2,TRPM3,ATP1A2
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.353e-02	-4.30	phospholipid transporter activity	molecular function	GO:0005548	64	2	18094	50	ABCA1,PITPNC1
1.363e-02	-4.30	central_nervous_system-cerebrum-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-cerebrum-glioma-astrocytoma_Grade_IV	61	2	16828	49	CNTN1,LRP1B
1.366e-02	-4.29	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	50	CLU
1.366e-02	-4.29	D-aspartate transmembrane transport	biological process	GO:0070777	5	1	18204	50	SLC1A2
1.366e-02	-4.29	dipeptide transport	biological process	GO:0042938	5	1	18204	50	SLC7A11
1.366e-02	-4.29	oligopeptide import across plasma membrane	biological process	GO:0140205	5	1	18204	50	SLC7A11
1.366e-02	-4.29	D-aspartate import across plasma membrane	biological process	GO:0070779	5	1	18204	50	SLC1A2
1.366e-02	-4.29	dipeptide import across plasma membrane	biological process	GO:0140206	5	1	18204	50	SLC7A11
1.366e-02	-4.29	sphingolipid translocation	biological process	GO:0099039	5	1	18204	50	ABCA1
1.366e-02	-4.29	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	50	BMPR1B
1.366e-02	-4.29	activation of meiosis	biological process	GO:0090427	5	1	18204	50	PLCB1
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	regulation of ferroptosis	biological process	GO:0110075	5	1	18204	50	SLC7A11
1.366e-02	-4.29	dipeptide transmembrane transport	biological process	GO:0035442	5	1	18204	50	SLC7A11
1.366e-02	-4.29	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	50	NTRK2
1.366e-02	-4.29	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	50	FMN2
1.366e-02	-4.29	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	50	CLU
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	NTRK2,KALRN,ATP1A2,LRP1B,HIF3A,PARD3B,SOX5,DCLK2,PLCB1,GPM6A,AHCYL1,RYR3,MAP3K5,PARD3,EFEMP1,EYA2,BMPR1B,TRPS1,AQP4,NPAS3,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,LSAMP,PRKCA,ABCA1,SLC1A2,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,NEBL,MSI2,NRG3,SORBS1,ADCY2,DTNA,PTPRZ1,FYN,FMN2,CLU,RFX4,CTNND2,ARHGEF4,GPC5
1.374e-02	-4.29	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	50	BMPR1B
1.374e-02	-4.29	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	1	18094	50	SLC1A2
1.374e-02	-4.29	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	50	NTRK2
1.374e-02	-4.29	glutamate:sodium symporter activity	molecular function	GO:0015501	5	1	18094	50	SLC1A2
1.374e-02	-4.29	apolipoprotein A-I binding	molecular function	GO:0034186	5	1	18094	50	ABCA1
1.375e-02	-4.29	Dopaminergic synapse	KEGG pathways	hsa04728	130	3	7161	28	PLCB1,MAPK10,PRKCA
1.375e-02	-4.29	Dopaminergic synapse	KEGG pathways	ko04728	130	3	7161	28	PRKCA,MAPK10,PLCB1
1.377e-02	-4.29	apoptotic mitochondrial changes	biological process	GO:0008637	65	2	18204	50	CLU,EYA2
1.391e-02	-4.27	cell projection membrane	cellular component	GO:0031253	356	4	19108	50	SLC1A2,SLC7A11,ARHGEF4,MACF1
1.395e-02	-4.27	T Cell Receptor Signaling Pathway	SMPDB pathways	SMP0066977	44	2	1369	6	FYN,PRKCA
1.399e-02	-4.27	NCAM1 (neural cell adhesion molecule 1)	protein interactions	4684	70	2	19454	50	FYN,GPM6A
1.404e-02	-4.27	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	4	16828	49	CTNND2,FMN2,LRP1B,ATP1A2
1.414e-02	-4.26	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	3	19454	50	FYN,NEBL,NTRK2
1.418e-02	-4.26	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	49	TRPS1,NPAS3,AQP4,BMPR1B,ABLIM1,HPSE2,TSHZ2,TRPM3,MACF1,MAP3K5,PARD3,EFEMP1,RYR3,EYA2,DCLK2,SOX5,PARD3B,PLCB1,PITPNC1,AHCYL1,GPM6A,KALRN,ATP1A2,LRP1B,NTRK2,HIF3A,RFX4,CLU,FMN2,PTPRZ1,FYN,ARHGEF4,GPC5,CTNND2,SORBS1,ADCY2,DTNA,NEBL,NRG3,ABCA1,SLC1A2,LSAMP,PRKCA,RORA,NRCAM,GLIS3,CNTN1,SLC7A11
1.418e-02	-4.26	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	49	HIF3A,LRP1B,KALRN,ATP1A2,NTRK2,AHCYL1,GPM6A,PARD3B,DCLK2,SOX5,PLCB1,PITPNC1,EYA2,MAP3K5,PARD3,EFEMP1,RYR3,ABLIM1,HPSE2,TSHZ2,TRPM3,MACF1,TRPS1,NPAS3,AQP4,BMPR1B,NRCAM,RORA,GLIS3,SLC7A11,CNTN1,ABCA1,SLC1A2,LSAMP,PRKCA,NRG3,NEBL,DTNA,ADCY2,SORBS1,ARHGEF4,GPC5,CTNND2,FMN2,CLU,RFX4,PTPRZ1,FYN
1.418e-02	-4.26	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	50	SLC1A2,SLC7A11
1.418e-02	-4.26	ERBB signaling pathway	biological process	GO:0038127	66	2	18204	50	EFEMP1,NRG3
1.418e-02	-4.26	peptidyl-tyrosine phosphorylation	biological process	GO:0018108	66	2	18204	50	FYN,EFEMP1
1.423e-02	-4.25	Erythroid Transcription Factor GATA-1, subunit A	gene3d domains	3.30.50.10	56	2	14470	47	RORA,TRPS1
1.430e-02	-4.25	angiogenesis	biological process	GO:0001525	342	4	18204	50	PRKCA,NRCAM,HIF3A,RORA
1.434e-02	-4.24	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	50	SLC7A11,SLC1A2
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	NRCAM,GPM6A
1.437e-02	-4.24	MAP2K4 (mitogen-activated protein kinase kinase 4)	protein interactions	6416	71	2	19454	50	MAPK10,MAP3K5
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	MACF1,PARD3
1.437e-02	-4.24	DOK4 (docking protein 4)	protein interactions	55715	71	2	19454	50	AHCYL1,FYN
1.459e-02	-4.23	cholesterol transport	biological process	GO:0030301	67	2	18204	50	ABCA1,CLU
1.468e-02	-4.22	LNX1 (ligand of numb-protein X 1)	protein interactions	84708	565	5	19454	50	ABCA1,PRKCA,KALRN,CTNND2,NRCAM
1.469e-02	-4.22	NEBULIN	prosite domains	PS51216	4	1	12186	45	NEBL
1.476e-02	-4.22	GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A)	protein interactions	2903	72	2	19454	50	FYN,PRKCA
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	PARD3B,BMPR1B
1.476e-02	-4.22	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	50	ABLIM1,PARD3
1.476e-02	-4.22	cell adhesion mediator activity	molecular function	GO:0098631	67	2	18094	50	NRCAM,CNTN1
1.476e-02	-4.22	sterol binding	molecular function	GO:0032934	67	2	18094	50	ABCA1,RORA
1.481e-02	-4.21	blood vessel development	biological process	GO:0001568	530	5	18204	50	NTRK2,PRKCA,NRCAM,HIF3A,RORA
1.490e-02	-4.21	EGF_CA	pfam domains	PF07645	69	2	17795	48	EFEMP1,LRP1B
1.490e-02	-4.21	LIM	pfam domains	PF00412	69	2	17795	48	ABLIM1,NEBL
1.501e-02	-4.20	cellular response to hydrogen peroxide	biological process	GO:0070301	68	2	18204	50	MAP3K5,FYN
1.501e-02	-4.20	peptidyl-tyrosine modification	biological process	GO:0018212	68	2	18204	50	FYN,EFEMP1
1.501e-02	-4.20	actin filament bundle organization	biological process	GO:0061572	68	2	18204	50	SORBS1,FMN2
1.510e-02	-4.19	extracellular matrix	cellular component	GO:0031012	559	5	19108	50	EFEMP1,HPSE2,GPC5,CLU,PTPRZ1
1.521e-02	-4.19	external encapsulating structure	cellular component	GO:0030312	560	5	19108	50	EFEMP1,HPSE2,GPC5,CLU,PTPRZ1
1.526e-02	-4.18	cellular response to lipid	biological process	GO:0071396	534	5	18204	50	RORA,ATP1A2,ADCY2,PLCB1,ABCA1
1.531e-02	-4.18	RhoGEF	pfam domains	PF00621	70	2	17795	48	KALRN,ARHGEF4
1.531e-02	-4.18	pallium development	biological process	GO:0021543	190	3	18204	50	NTRK2,DCLK2,PLCB1
1.531e-02	-4.18	CERS2 (ceramide synthase 2)	protein interactions	29956	203	3	19454	50	FYN,CNTN1,PRKCA
1.532e-02	-4.18	ARMS2 (age-related maculopathy susceptibility 2)	protein interactions	387715	6	1	19454	50	PRKCA
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	Rara (retinoic acid receptor, alpha)	protein interactions	19401	6	1	19454	50	MAPK10
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	Csnk1d (casein kinase 1, delta)	protein interactions	64462	6	1	19454	50	PRKCA
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.535e-02	-4.18	DH-domain	interpro domains	IPR000219	70	2	18521	50	KALRN,ARHGEF4
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	PARD3B,DTNA,ABLIM1
1.554e-02	-4.16	RNF6 (ring finger protein 6)	protein interactions	6049	74	2	19454	50	ABLIM1,AHCYL1
1.554e-02	-4.16	GNAZ (G protein subunit alpha z)	protein interactions	2781	74	2	19454	50	EYA2,GPM6A
1.560e-02	-4.16	PAR polarity complex	cellular component	GO:0120157	6	1	19108	50	PARD3
1.561e-02	-4.16	CDC42 (cell division cycle 42)	protein interactions	998	1280	8	19454	50	ARHGEF4,FMN2,FYN,PARD3,ABCA1,PRKCA,AHCYL1,SLC7A11
1.561e-02	-4.16	monoatomic ion transport	biological process	GO:0006811	964	7	18204	50	RYR3,SLC1A2,TRPM3,GPM6A,ATP1A2,PLCB1,FYN
1.573e-02	-4.15	RHOC (ras homolog family member C)	protein interactions	389	575	5	19454	50	SLC7A11,MACF1,PARD3B,FYN,PARD3
1.573e-02	-4.15	NRAGE signals death through JNK	REACTOME pathways	R-HSA-193648	60	2	10285	33	ARHGEF4,KALRN
1.576e-02	-4.15	Spinal Cord Injury	WikiPathways	WP2431	119	3	5310	24	PRKCA,AQP4,PTPRZ1
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	ABLIM1,NEBL
1.576e-02	-4.15	DBL_dom_sf	interpro domains	IPR035899	71	2	18521	50	KALRN,ARHGEF4
1.585e-02	-4.14	GnRH Signaling Pathway	SMPDB pathways	SMP0063811	47	2	1369	6	PLCB1,PRKCA
1.592e-02	-4.14	cellular process	biological process	GO:0009987	14996	47	18204	50	RFX4,NTRK2,SLC1A2,MACF1,NRCAM,PLCB1,MAPK10,SLC7A11,PTPRZ1,NRG3,ARHGEF4,PRKCA,TRPM3,SOX5,RYR3,CTNND2,EFEMP1,MAP3K5,LRP1B,RORA,HPSE2,GPC5,MSI2,FYN,AHCYL1,PARD3,AQP4,PITPNC1,EYA2,KALRN,ATP1A2,FMN2,NEBL,PARD3B,HIF3A,LSAMP,ADCY2,DTNA,GPM6A,CNTN1,ABCA1,CLU,GLIS3,SORBS1,ABLIM1,BMPR1B,DCLK2
1.594e-02	-4.14	Reelin signalling pathway	REACTOME pathways	R-HSA-8866376	5	1	10285	33	FYN
1.594e-02	-4.14	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	33	NTRK2
1.594e-02	-4.14	Disinhibition of SNARE formation	REACTOME pathways	R-HSA-114516	5	1	10285	33	PRKCA
1.600e-02	-4.13	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	9	16828	49	ATP1A2,LRP1B,PARD3B,RYR3,FYN,HPSE2,TRPM3,MACF1,CTNND2
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	HIF3A,LRP1B,KALRN,ATP1A2,NTRK2,AHCYL1,GPM6A,PLCB1,DCLK2,SOX5,PARD3B,EYA2,EFEMP1,PARD3,MAP3K5,RYR3,HPSE2,ABLIM1,MACF1,TRPM3,TSHZ2,AQP4,NPAS3,TRPS1,BMPR1B,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,SLC1A2,ABCA1,LSAMP,PRKCA,MSI2,NRG3,NEBL,DTNA,SORBS1,ADCY2,GPC5,ARHGEF4,CTNND2,CLU,RFX4,FMN2,FYN,PTPRZ1
1.608e-02	-4.13	EF-hand_3	pfam domains	PF09069	6	1	17795	48	DTNA
1.608e-02	-4.13	SH3_10	pfam domains	PF17902	6	1	17795	48	MACF1
1.608e-02	-4.13	GAS2	pfam domains	PF02187	6	1	17795	48	MACF1
1.608e-02	-4.13	RIH_assoc	pfam domains	PF08454	6	1	17795	48	RYR3
1.608e-02	-4.13	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	48	RYR3
1.608e-02	-4.13	Plectin	pfam domains	PF00681	6	1	17795	48	MACF1
1.608e-02	-4.13	Glypican	pfam domains	PF01153	6	1	17795	48	GPC5
1.608e-02	-4.13	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	48	ADCY2
1.608e-02	-4.13	RYDR_ITPR	pfam domains	PF01365	6	1	17795	48	RYR3
1.608e-02	-4.13	EF-hand_2	pfam domains	PF09068	6	1	17795	48	DTNA
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY2
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.610e-02	-4.13	central_nervous_system-brain-glioma	COSMIC cancer mutations	central_nervous_system-brain-glioma	15470	49	16828	49	GPC5,ARHGEF4,CTNND2,FMN2,RFX4,CLU,FYN,PTPRZ1,DTNA,ADCY2,SORBS1,MSI2,NRG3,NEBL,NRCAM,RORA,SLC7A11,CNTN1,GLIS3,SLC1A2,ABCA1,LSAMP,PRKCA,HPSE2,ABLIM1,MACF1,TRPM3,TSHZ2,AQP4,NPAS3,TRPS1,BMPR1B,EYA2,EFEMP1,PARD3,MAP3K5,RYR3,AHCYL1,GPM6A,PLCB1,PARD3B,DCLK2,SOX5,PITPNC1,HIF3A,KALRN,LRP1B,ATP1A2,NTRK2
1.613e-02	-4.13	Apelin signaling pathway	KEGG pathways	hsa04371	138	3	7161	28	ADCY2,RYR3,PLCB1
1.618e-02	-4.12	protein homooligomerization	biological process	GO:0051260	194	3	18204	50	SLC1A2,RYR3,AQP4
1.624e-02	-4.12	Ca2+ pathway	REACTOME pathways	R-HSA-4086398	61	2	10285	33	PLCB1,PRKCA
1.628e-02	-4.12	cerebrum	COSMIC cancer mutations	cerebrum	67	2	16828	49	LRP1B,CNTN1
1.633e-02	-4.11	BCL2L1 (BCL2 like 1)	protein interactions	598	208	3	19454	50	CLU,ABLIM1,RYR3
1.633e-02	-4.11	GATAD2A (GATA zinc finger domain containing 2A)	protein interactions	54815	208	3	19454	50	SOX5,TRPS1,FYN
1.635e-02	-4.11	RAPGEF6 (Rap guanine nucleotide exchange factor 6)	protein interactions	51735	76	2	19454	50	PARD3,ABCA1
1.637e-02	-4.11	NEBU	smart domains	SM00227	4	1	9717	40	NEBL
1.637e-02	-4.11	L-cystine transport	biological process	GO:0015811	6	1	18204	50	SLC7A11
1.637e-02	-4.11	cellular response to L-glutamate	biological process	GO:1905232	6	1	18204	50	FYN
1.637e-02	-4.11	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	50	FMN2
1.637e-02	-4.11	D-amino acid transport	biological process	GO:0042940	6	1	18204	50	SLC1A2
1.637e-02	-4.11	regulation of neutrophil apoptotic process	biological process	GO:0033029	6	1	18204	50	SLC7A11
1.637e-02	-4.11	regulation of AMPA glutamate receptor clustering	biological process	GO:1904717	6	1	18204	50	SLC7A11
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	mammary gland formation	biological process	GO:0060592	6	1	18204	50	NRG3
1.637e-02	-4.11	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	50	CLU
1.637e-02	-4.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	1	18204	50	SLC1A2
1.637e-02	-4.11	fused antrum stage	biological process	GO:0048165	6	1	18204	50	BMPR1B
1.637e-02	-4.11	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	50	NRG3
1.637e-02	-4.11	clustering of voltage-gated sodium channels	biological process	GO:0045162	6	1	18204	50	NRCAM
1.637e-02	-4.11	cellular response to ether	biological process	GO:0071362	6	1	18204	50	PLCB1
1.637e-02	-4.11	inositol trisphosphate metabolic process	biological process	GO:0032957	6	1	18204	50	PLCB1
1.637e-02	-4.11	intracellular water homeostasis	biological process	GO:0009992	6	1	18204	50	AQP4
1.637e-02	-4.11	apolipoprotein A-I-mediated signaling pathway	biological process	GO:0038027	6	1	18204	50	ABCA1
1.637e-02	-4.11	negative regulation of hydrogen peroxide metabolic process	biological process	GO:0010727	6	1	18204	50	FYN
1.637e-02	-4.11	regulation of glutamate receptor clustering	biological process	GO:0106104	6	1	18204	50	SLC7A11
1.637e-02	-4.11	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	GO:0106071	6	1	18204	50	PRKCA
1.637e-02	-4.11	regulation of glutamate receptor signaling pathway	biological process	GO:1900449	6	1	18204	50	FYN
1.637e-02	-4.11	intracellular glutamate homeostasis	biological process	GO:0090461	6	1	18204	50	SLC7A11
1.640e-02	-4.11	MAPK signaling pathway	KEGG pathways	ko04010	255	4	7161	28	MAP3K5,PRKCA,NTRK2,MAPK10
1.640e-02	-4.11	MAPK signaling pathway	KEGG pathways	hsa04010	255	4	7161	28	MAPK10,MAP3K5,PRKCA,NTRK2
1.647e-02	-4.11	type 5 metabotropic glutamate receptor binding	molecular function	GO:0031802	6	1	18094	50	FYN
1.647e-02	-4.11	steroid hormone binding	molecular function	GO:1990239	6	1	18094	50	ATP1A2
1.647e-02	-4.11	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	50	RYR3
1.653e-02	-4.10	purine nucleotide binding	molecular function	GO:0017076	1964	11	18094	50	BMPR1B,MAP3K5,ABCA1,ADCY2,ATP1A2,NTRK2,MAPK10,FYN,KALRN,DCLK2,PRKCA
1.670e-02	-4.09	KIF20A (kinesin family member 20A)	protein interactions	10112	1044	7	19454	50	RORA,NEBL,MACF1,MSI2,ABLIM1,PARD3,FYN
1.670e-02	-4.09	Amyotrophic lateral sclerosis (ALS)	KEGG pathways	ko05014	51	2	7161	28	MAP3K5,SLC1A2
1.670e-02	-4.09	Amyotrophic lateral sclerosis (ALS)	KEGG pathways	hsa05014	51	2	7161	28	SLC1A2,MAP3K5
1.676e-02	-4.09	ADD2 (adducin 2)	protein interactions	119	77	2	19454	50	FYN,PTPRZ1
1.676e-02	-4.09	ADGRL2 (adhesion G protein-coupled receptor L2)	protein interactions	23266	77	2	19454	50	PARD3,NTRK2
1.676e-02	-4.09	TAFA3 (TAFA chemokine like family member 3)	protein interactions	284467	77	2	19454	50	AHCYL1,LRP1B
1.696e-02	-4.08	CDK6 (cyclin dependent kinase 6)	protein interactions	1021	211	3	19454	50	SOX5,SORBS1,MAP3K5
1.696e-02	-4.08	PTPRF (protein tyrosine phosphatase receptor type F)	protein interactions	5792	211	3	19454	50	CLU,PTPRZ1,FYN
1.701e-02	-4.07	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	9	16828	49	FYN,RYR3,LRP1B,ATP1A2,PARD3B,MACF1,TRPM3,CTNND2,HPSE2
1.709e-02	-4.07	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	11	16828	49	PTPRZ1,PITPNC1,FMN2,PLCB1,NEBL,HPSE2,RYR3,NTRK2,PARD3,ADCY2,LRP1B
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.713e-02	-4.07	vasculature development	biological process	GO:0001944	550	5	18204	50	RORA,HIF3A,NRCAM,PRKCA,NTRK2
1.715e-02	-4.07	extremity	COSMIC cancer mutations	extremity	1876	11	16828	49	PLCB1,NEBL,LRP1B,ADCY2,PARD3,FMN2,PITPNC1,PTPRZ1,NTRK2,RYR3,HPSE2
1.716e-02	-4.07	regulation of myoblast differentiation	biological process	GO:0045661	73	2	18204	50	PLCB1,MAP3K5
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	MSI2,SOX5
1.717e-02	-4.06	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	50	CLU,SLC7A11
1.717e-02	-4.06	regulation of multicellular organismal process	biological process	GO:0051239	3113	15	18204	50	PARD3,PRKCA,TRPS1,FYN,CLU,EFEMP1,MACF1,ABCA1,SOX5,NTRK2,BMPR1B,RORA,ATP1A2,PLCB1,PTPRZ1
1.736e-02	-4.05	cargo receptor activity	molecular function	GO:0038024	73	2	18094	50	LRP1B,ABCA1
1.739e-02	-4.05	SIAH1 (siah E3 ubiquitin protein ligase 1)	protein interactions	6477	213	3	19454	50	MAP3K5,PARD3,FYN
1.740e-02	-4.05	membrane organization	biological process	GO:0061024	761	6	18204	50	PRKCA,NRCAM,EYA2,PITPNC1,ABCA1,CLU
1.741e-02	-4.05	Fluid shear stress and atherosclerosis	KEGG pathways	ko05418	142	3	7161	28	MAP3K5,MAPK10,BMPR1B
1.741e-02	-4.05	Fluid shear stress and atherosclerosis	KEGG pathways	hsa05418	142	3	7161	28	MAP3K5,BMPR1B,MAPK10
1.746e-02	-4.05	ER-PR-positive_carcinoma	COSMIC cancer mutations	ER-PR-positive_carcinoma	1881	11	16828	49	PRKCA,NTRK2,ABCA1,MAP3K5,CNTN1,EYA2,FYN,BMPR1B,NPAS3,MSI2,NRG3
1.746e-02	-4.05	breast-carcinoma-ER-PR-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-ER-PR-positive_carcinoma	1881	11	16828	49	ABCA1,MAP3K5,NPAS3,PRKCA,NTRK2,FYN,BMPR1B,NRG3,MSI2,EYA2,CNTN1
1.750e-02	-4.05	carbohydrate derivative binding	molecular function	GO:0097367	2251	12	18094	50	FYN,NTRK2,ADCY2,MAP3K5,DCLK2,PRKCA,KALRN,MAPK10,ABCA1,HPSE2,ATP1A2,BMPR1B
1.758e-02	-4.04	positive regulation of response to stimulus	biological process	GO:0048584	2266	12	18204	50	GPC5,FMN2,SORBS1,BMPR1B,MAP3K5,PLCB1,MACF1,CLU,NTRK2,EYA2,FYN,PRKCA
1.759e-02	-4.04	VPS4B (vacuolar protein sorting 4 homolog B)	protein interactions	9525	79	2	19454	50	PRKCA,AHCYL1
1.759e-02	-4.04	STMN2 (stathmin 2)	protein interactions	11075	79	2	19454	50	AHCYL1,MAPK10
1.759e-02	-4.04	PALS2 (protein associated with LIN7 2, MAGUK p55 family member)	protein interactions	51678	79	2	19454	50	TRPS1,ABCA1
1.761e-02	-4.04	sterol transport	biological process	GO:0015918	74	2	18204	50	CLU,ABCA1
1.761e-02	-4.04	phosphoric ester hydrolase activity	molecular function	GO:0042578	362	4	18094	50	ATP1A2,PLCB1,EYA2,PTPRZ1
1.773e-02	-4.03	Wnt signaling pathway	KEGG pathways	ko04310	143	3	7161	28	MAPK10,PLCB1,PRKCA
1.773e-02	-4.03	Wnt signaling pathway	KEGG pathways	hsa04310	143	3	7161	28	PRKCA,PLCB1,MAPK10
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	TPM3P4 (tropomyosin 3 pseudogene 4)	protein interactions	402643	7	1	19454	50	AHCYL1
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.789e-02	-4.02	Developmental Biology	REACTOME pathways	R-HSA-1266738	1075	8	10285	33	ABLIM1,NRCAM,KALRN,HIF3A,PRKCA,CNTN1,FYN,NRG3
1.791e-02	-4.02	monoatomic cation transport	biological process	GO:0006812	766	6	18204	50	RYR3,PLCB1,FYN,TRPM3,GPM6A,ATP1A2
1.801e-02	-4.02	GJB1 (gap junction protein beta 1)	protein interactions	2705	80	2	19454	50	PRKCA,MSI2
1.801e-02	-4.02	MAP2 (microtubule associated protein 2)	protein interactions	4133	80	2	19454	50	GPM6A,FYN
1.804e-02	-4.01	ATP2B1 (ATPase plasma membrane Ca2+ transporting 1)	protein interactions	490	216	3	19454	50	NTRK2,PRKCA,PARD3
1.805e-02	-4.01	PITRANSFER	prints domains	PR00391	5	1	5227	19	PITPNC1
1.815e-02	-4.01	alveolar	COSMIC cancer mutations	alveolar	2414	13	16828	49	RYR3,PARD3,SORBS1,LRP1B,ABCA1,NPAS3,FMN2,PARD3B,CLU,TRPS1,TRPM3,MACF1,TSHZ2
1.815e-02	-4.01	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	13	16828	49	TSHZ2,MACF1,TRPM3,CLU,TRPS1,FMN2,PARD3B,NPAS3,LRP1B,ABCA1,PARD3,SORBS1,RYR3
1.826e-02	-4.00	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	3	19454	50	PRKCA,ABLIM1,RORA
1.831e-02	-4.00	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	33	NRG3,FYN
1.843e-02	-3.99	DUSP11 (dual specificity phosphatase 11)	protein interactions	8446	81	2	19454	50	PRKCA,AHCYL1
1.852e-02	-3.99	regulation of axon extension	biological process	GO:0030516	76	2	18204	50	NRCAM,MACF1
1.865e-02	-3.98	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	72	2	16828	49	LRP1B,FMN2
1.865e-02	-3.98	cortisol_producing	COSMIC cancer mutations	cortisol_producing	72	2	16828	49	LRP1B,FMN2
1.871e-02	-3.98	ErbB4 signaling events	Pathway Interaction DB	erbb4_pathway	32	2	2226	15	NRG3,FYN
1.873e-02	-3.98	SDF	pfam domains	PF00375	7	1	17795	48	SLC1A2
1.873e-02	-3.98	TGF_beta_GS	pfam domains	PF08515	7	1	17795	48	BMPR1B
1.875e-02	-3.98	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Aquaporin_transptr	interpro domains	IPR034294	7	1	18521	50	AQP4
1.875e-02	-3.98	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.881e-02	-3.97	HAX1 (HCLS1 associated protein X-1)	protein interactions	10456	397	4	19454	50	MAPK10,CLU,CNTN1,GPM6A
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	EYA2,ATP1A2
1.886e-02	-3.97	TNNT1 (troponin T1, slow skeletal type)	protein interactions	7138	82	2	19454	50	BMPR1B,FYN
1.886e-02	-3.97	GSC (goosecoid homeobox)	protein interactions	145258	82	2	19454	50	TRPS1,SOX5
1.897e-02	-3.97	PRKCZ (protein kinase C zeta)	protein interactions	5590	398	4	19454	50	FYN,PARD3,PTPRZ1,PRKCA
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.898e-02	-3.96	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	50	MACF1,NTRK2
1.898e-02	-3.96	cellular response to interleukin-1	biological process	GO:0071347	77	2	18204	50	PLCB1,RORA
1.898e-02	-3.96	neural retina development	biological process	GO:0003407	77	2	18204	50	NTRK2,GPM6A
1.907e-02	-3.96	post-embryonic eye morphogenesis	biological process	GO:0048050	7	1	18204	50	EFEMP1
1.907e-02	-3.96	glutathione transmembrane transport	biological process	GO:0034775	7	1	18204	50	SLC7A11
1.907e-02	-3.96	S-adenosylmethionine cycle	biological process	GO:0033353	7	1	18204	50	AHCYL1
1.907e-02	-3.96	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	50	FMN2
1.907e-02	-3.96	mitochondrion-endoplasmic reticulum membrane tethering	biological process	GO:1990456	7	1	18204	50	AHCYL1
1.907e-02	-3.96	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	50	FMN2
1.907e-02	-3.96	regulation of monocyte extravasation	biological process	GO:2000437	7	1	18204	50	PLCB1
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	50	NRG3
1.907e-02	-3.96	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	50	CLU
1.907e-02	-3.96	regulation of glutamine family amino acid metabolic process	biological process	GO:0000820	7	1	18204	50	SLC7A11
1.907e-02	-3.96	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	50	PTPRZ1
1.907e-02	-3.96	regulation of hydrogen peroxide biosynthetic process	biological process	GO:0010728	7	1	18204	50	FYN
1.910e-02	-3.96	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	33	NTRK2
1.916e-02	-3.95	RPS6KA1 (ribosomal protein S6 kinase A1)	protein interactions	6195	221	3	19454	50	FYN,PARD3B,DTNA
1.919e-02	-3.95	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	50	PITPNC1
1.919e-02	-3.95	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	50	ATP1A2
1.919e-02	-3.95	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	50	ATP1A2
1.927e-02	-3.95	Pathogenic Escherichia coli infection	KEGG pathways	ko05130	55	2	7161	28	FYN,PRKCA
1.927e-02	-3.95	Pathogenic Escherichia coli infection	KEGG pathways	hsa05130	55	2	7161	28	PRKCA,FYN
1.933e-02	-3.95	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	47	RYR3
1.933e-02	-3.95	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	47	MACF1
1.933e-02	-3.95	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	47	MACF1
1.944e-02	-3.94	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	50	SORBS1,SLC1A2
1.972e-02	-3.93	regulation of primary metabolic process	biological process	GO:0080090	5680	23	18204	50	NPAS3,SORBS1,RORA,BMPR1B,MAP3K5,GLIS3,EFEMP1,CLU,SOX5,TSHZ2,TRPS1,PRKCA,SLC7A11,HIF3A,FMN2,PLCB1,NTRK2,AHCYL1,PARD3,RFX4,EYA2,MSI2,FYN
1.974e-02	-3.93	TMEM185A (transmembrane protein 185A)	protein interactions	84548	84	2	19454	50	FYN,PRKCA
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	FYN,NTRK2
1.977e-02	-3.92	chondrosarcoma	COSMIC cancer mutations	chondrosarcoma	1181	8	16828	49	LSAMP,LRP1B,ABCA1,KALRN,PARD3B,ADCY2,CNTN1,HPSE2
1.978e-02	-3.92	cytoskeleton organization	biological process	GO:0007010	1251	8	18204	50	ABLIM1,PARD3,SORBS1,MACF1,FMN2,DCLK2,NEBL,PARD3B
1.978e-02	-3.92	external side of plasma membrane	cellular component	GO:0009897	396	4	19108	50	MAP3K5,NRCAM,ABCA1,AQP4
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	GPM6A,MACF1,ABLIM1
1.991e-02	-3.92	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	5	19454	50	ABLIM1,CLU,AHCYL1,PARD3,DTNA
1.996e-02	-3.91	caveola	cellular component	GO:0005901	83	2	19108	50	ATP1A2,SORBS1
2.009e-02	-3.91	Ephrin A reverse signaling	Pathway Interaction DB	ephrinarevpathway	3	1	2226	15	FYN
2.018e-02	-3.90	CFAP298 (cilia and flagella associated protein 298)	protein interactions	56683	85	2	19454	50	TRPS1,FMN2
2.022e-02	-3.90	nitrogen compound transport	biological process	GO:0071705	1507	9	18204	50	NTRK2,SLC1A2,FMN2,ABCA1,SLC7A11,CLU,MACF1,AHCYL1,LRP1B
2.038e-02	-3.89	CD163 (CD163 molecule)	protein interactions	9332	8	1	19454	50	PRKCA
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.038e-02	-3.89	Marcks (myristoylated alanine rich protein kinase C substrate)	protein interactions	17118	8	1	19454	50	PRKCA
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	Prkca (protein kinase C, alpha)	protein interactions	24680	8	1	19454	50	PRKCA
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	Melk (maternal embryonic leucine zipper kinase)	protein interactions	17279	8	1	19454	50	MAP3K5
2.039e-02	-3.89	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	9	16828	49	SLC1A2,CLU,RFX4,ATP1A2,FMN2,PITPNC1,NTRK2,PRKCA,CTNND2
2.039e-02	-3.89	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	9	16828	49	PRKCA,NTRK2,PITPNC1,ATP1A2,RFX4,CLU,FMN2,SLC1A2,CTNND2
2.044e-02	-3.89	synaptic membrane	cellular component	GO:0097060	400	4	19108	50	SLC1A2,GPM6A,NRCAM,CNTN1
2.045e-02	-3.89	VEGFA-VEGFR2 Pathway	REACTOME pathways	R-HSA-4420097	330	4	10285	33	AHCYL1,FYN,NRG3,PRKCA
2.048e-02	-3.89	IG_LIKE	prosite domains	PS50835	430	5	12186	45	NTRK2,NRCAM,CNTN1,LSAMP,KALRN
2.051e-02	-3.89	actin filament binding	molecular function	GO:0051015	211	3	18094	50	MACF1,ABLIM1,NEBL
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	SORBS1,GPM6A
2.063e-02	-3.88	FAM171A1 (family with sequence similarity 171 member A1)	protein interactions	221061	86	2	19454	50	NTRK2,PARD3
2.073e-02	-3.88	stomach	COSMIC cancer mutations	stomach	15550	49	16828	49	HIF3A,NTRK2,KALRN,ATP1A2,LRP1B,GPM6A,AHCYL1,PITPNC1,PLCB1,PARD3B,DCLK2,SOX5,EYA2,RYR3,EFEMP1,MAP3K5,PARD3,MACF1,TRPM3,TSHZ2,HPSE2,ABLIM1,BMPR1B,AQP4,NPAS3,TRPS1,SLC7A11,CNTN1,GLIS3,NRCAM,RORA,PRKCA,LSAMP,SLC1A2,ABCA1,MSI2,NRG3,NEBL,DTNA,SORBS1,ADCY2,CTNND2,GPC5,ARHGEF4,FYN,PTPRZ1,FMN2,CLU,RFX4
2.075e-02	-3.88	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	50	BMPR1B
2.075e-02	-3.88	zonula adherens	cellular component	GO:0005915	8	1	19108	50	SORBS1
2.075e-02	-3.88	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	50	CLU
2.085e-02	-3.87	human chr4q28.3	chromosome location	human chr4q28.3	11	1	26134	50	SLC7A11
2.103e-02	-3.86	PCNT (pericentrin)	protein interactions	5116	229	3	19454	50	MACF1,KALRN,AHCYL1
2.106e-02	-3.86	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	4	16828	49	CTNND2,TRPM3,MACF1,KALRN
2.108e-02	-3.86	PLCG2 (phospholipase C gamma 2)	protein interactions	5336	87	2	19454	50	PRKCA,FYN
2.117e-02	-3.86	sensory organ development	biological process	GO:0007423	581	5	18204	50	BMPR1B,GPM6A,EFEMP1,SLC7A11,NTRK2
2.127e-02	-3.85	DST (dystonin)	protein interactions	667	230	3	19454	50	PARD3,NTRK2,ATP1A2
2.138e-02	-3.85	LSDAT_euk	pfam domains	PF18139	8	1	17795	48	TRPM3
2.138e-02	-3.85	DCX	pfam domains	PF03607	8	1	17795	48	DCLK2
2.138e-02	-3.85	VHP	pfam domains	PF02209	8	1	17795	48	ABLIM1
2.138e-02	-3.85	AC_N	pfam domains	PF16214	8	1	17795	48	ADCY2
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY2
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY2
2.146e-02	-3.84	CDC37 (cell division cycle 37, HSP90 cochaperone)	protein interactions	11140	623	5	19454	50	FYN,DCLK2,PRKCA,AHCYL1,NTRK2
2.153e-02	-3.84	TIMP3 (TIMP metallopeptidase inhibitor 3)	protein interactions	7078	88	2	19454	50	LRP1B,EFEMP1
2.162e-02	-3.83	ACTIVIN2R	prints domains	PR00653	6	1	5227	19	BMPR1B
2.168e-02	-3.83	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	9	16828	49	PTPRZ1,RYR3,NEBL,RFX4,LRP1B,FMN2,CNTN1,MACF1,CTNND2
2.168e-02	-3.83	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	9	16828	49	NEBL,FMN2,RFX4,LRP1B,RYR3,PTPRZ1,CTNND2,CNTN1,MACF1
2.174e-02	-3.83	pancreas-carcinoma-ductal_carcinoma	COSMIC cancer mutations	pancreas-carcinoma-ductal_carcinoma	15565	49	16828	49	CTNND2,ARHGEF4,GPC5,PTPRZ1,FYN,FMN2,RFX4,CLU,DTNA,ADCY2,SORBS1,NRG3,MSI2,NEBL,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,LSAMP,PRKCA,ABCA1,SLC1A2,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,BMPR1B,TRPS1,AQP4,NPAS3,EYA2,RYR3,MAP3K5,PARD3,EFEMP1,GPM6A,AHCYL1,PITPNC1,PARD3B,DCLK2,SOX5,PLCB1,HIF3A,NTRK2,KALRN,LRP1B,ATP1A2
2.175e-02	-3.83	ARNT (aryl hydrocarbon receptor nuclear translocator)	protein interactions	405	232	3	19454	50	NPAS3,FYN,HIF3A
2.175e-02	-3.83	Ion Channel and Phorbal Esters Signaling Pathway	SMPDB pathways	SMP0090032	5	1	1369	6	PRKCA
2.175e-02	-3.83	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	6	ADCY2
2.177e-02	-3.83	protein import	biological process	GO:0017038	8	1	18204	50	CLU
2.177e-02	-3.83	ion channel modulating, G protein-coupled receptor signaling pathway	biological process	GO:0099105	8	1	18204	50	PLCB1
2.177e-02	-3.83	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	50	RORA
2.177e-02	-3.83	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	50	RORA
2.177e-02	-3.83	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	50	ABCA1
2.177e-02	-3.83	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	50	FMN2
2.177e-02	-3.83	mesodermal cell fate specification	biological process	GO:0007501	8	1	18204	50	EYA2
2.177e-02	-3.83	central nervous system myelin formation	biological process	GO:0032289	8	1	18204	50	CNTN1
2.177e-02	-3.83	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	50	RORA
2.177e-02	-3.83	cellular response to vasopressin	biological process	GO:1904117	8	1	18204	50	PLCB1
2.177e-02	-3.83	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	biological process	GO:0007207	8	1	18204	50	PLCB1
2.177e-02	-3.83	response to vasopressin	biological process	GO:1904116	8	1	18204	50	PLCB1
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.177e-02	-3.83	mitotic nuclear membrane disassembly	biological process	GO:0007077	8	1	18204	50	PRKCA
2.177e-02	-3.83	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	50	NRG3
2.178e-02	-3.83	actin-based cell projection	cellular component	GO:0098858	228	3	19108	50	SLC7A11,GPM6A,FMN2
2.186e-02	-3.82	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	49	PLCB1,FMN2,MAP3K5,PARD3B,LRP1B
2.189e-02	-3.82	IG	smart domains	SM00409	394	5	9717	40	NTRK2,NRCAM,LSAMP,CNTN1,KALRN
2.190e-02	-3.82	sodium ion binding	molecular function	GO:0031402	8	1	18094	50	ATP1A2
2.190e-02	-3.82	phosphatidylcholine floppase activity	molecular function	GO:0090554	8	1	18094	50	ABCA1
2.190e-02	-3.82	BMP receptor activity	molecular function	GO:0098821	8	1	18094	50	BMPR1B
2.190e-02	-3.82	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	50	ATP1A2
2.196e-02	-3.82	GLYPICAN	prosite domains	PS01207	6	1	12186	45	GPC5
2.196e-02	-3.82	GAR	prosite domains	PS51460	6	1	12186	45	MACF1
2.199e-02	-3.82	PLEKHA2 (pleckstrin homology domain containing A2)	protein interactions	59339	89	2	19454	50	AHCYL1,DTNA
2.199e-02	-3.82	SLC25A41 (solute carrier family 25 member 41)	protein interactions	284427	89	2	19454	50	FYN,PRKCA
2.212e-02	-3.81	Signaling by VEGF	REACTOME pathways	R-HSA-194138	338	4	10285	33	PRKCA,NRG3,FYN,AHCYL1
2.212e-02	-3.81	RHOJ (ras homolog family member J)	protein interactions	57381	628	5	19454	50	MACF1,PARD3,AHCYL1,SLC7A11,BMPR1B
2.216e-02	-3.81	monoatomic ion transmembrane transport	biological process	GO:0034220	804	6	18204	50	SLC1A2,PLCB1,RYR3,GPM6A,TRPM3,ATP1A2
2.225e-02	-3.81	NrCAM interactions	REACTOME pathways	R-HSA-447038	7	1	10285	33	NRCAM
2.226e-02	-3.80	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	2	14470	47	KALRN,ARHGEF4
2.233e-02	-3.80	peripheral nervous system development	biological process	GO:0007422	84	2	18204	50	NTRK2,PARD3
2.233e-02	-3.80	L-amino acid transport	biological process	GO:0015807	84	2	18204	50	SLC7A11,SLC1A2
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	FMN2,DTNA
2.246e-02	-3.80	CDKN2C (cyclin dependent kinase inhibitor 2C)	protein interactions	1031	90	2	19454	50	MAPK10,AHCYL1
2.246e-02	-3.80	SEMG1 (semenogelin 1)	protein interactions	6406	90	2	19454	50	CLU,PRKCA
2.252e-02	-3.79	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	1	14470	47	SLC1A2
2.258e-02	-3.79	regulation of metal ion transport	biological process	GO:0010959	393	4	18204	50	FYN,AHCYL1,ATP1A2,CNTN1
2.259e-02	-3.79	phosphatidylinositol-4,5-bisphosphate binding	molecular function	GO:0005546	84	2	18094	50	PARD3,PLCB1
2.269e-02	-3.79	Long-term depression	KEGG pathways	hsa04730	60	2	7161	28	PLCB1,PRKCA
2.269e-02	-3.79	Long-term depression	KEGG pathways	ko04730	60	2	7161	28	PRKCA,PLCB1
2.283e-02	-3.78	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	5	18094	50	RYR3,SLC1A2,GPM6A,TRPM3,ATP1A2
2.283e-02	-3.78	chondrocyte differentiation	biological process	GO:0002062	85	2	18204	50	SOX5,BMPR1B
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	ZNF778 (zinc finger protein 778)	protein interactions	197320	9	1	19454	50	EFEMP1
2.290e-02	-3.78	SCTR (secretin receptor)	protein interactions	6344	9	1	19454	50	PRKCA
2.290e-02	-3.78	ARHGAP33 (Rho GTPase activating protein 33)	protein interactions	115703	9	1	19454	50	FYN
2.290e-02	-3.78	BIN2 (bridging integrator 2)	protein interactions	51411	9	1	19454	50	EFEMP1
2.290e-02	-3.78	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	1	19454	50	LSAMP
2.290e-02	-3.78	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	1	19454	50	LSAMP
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.292e-02	-3.78	PTPN21 (protein tyrosine phosphatase non-receptor type 21)	protein interactions	11099	91	2	19454	50	AHCYL1,NRG3
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	GPM6A,CNTN1
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	FYN,SORBS1
2.294e-02	-3.77	Penbutolol Action Pathway	SMPDB pathways	SMP0000305	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Nitrendipine Action Pathway	SMPDB pathways	SMP0000382	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Timolol Action Pathway	SMPDB pathways	SMP0000659	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Isradipine Action Pathway	SMPDB pathways	SMP0000378	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Procainamide (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000324	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Diltiazem Action Pathway	SMPDB pathways	SMP0000359	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Metoprolol Action Pathway	SMPDB pathways	SMP0000302	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Atenolol Action Pathway	SMPDB pathways	SMP0000298	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Mexiletine Action Pathway	SMPDB pathways	SMP0000329	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Alprenolol Action Pathway	SMPDB pathways	SMP0000297	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Flecainide Action Pathway	SMPDB pathways	SMP0000331	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Nimodipine Action Pathway	SMPDB pathways	SMP0000380	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Felodipine Action Pathway	SMPDB pathways	SMP0000377	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Disopyramide Action Pathway	SMPDB pathways	SMP0000325	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Amlodipine Action Pathway	SMPDB pathways	SMP0000376	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Bisoprolol Action Pathway	SMPDB pathways	SMP0000300	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Oxprenolol Action Pathway	SMPDB pathways	SMP0000304	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Acebutolol Action Pathway	SMPDB pathways	SMP0000296	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Fosphenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000326	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Esmolol Action Pathway	SMPDB pathways	SMP0000301	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Bopindolol Action Pathway	SMPDB pathways	SMP0000657	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Nisoldipine Action Pathway	SMPDB pathways	SMP0000381	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Verapamil Action Pathway	SMPDB pathways	SMP0000375	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Tocainide Action Pathway	SMPDB pathways	SMP0000330	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Pindolol Action Pathway	SMPDB pathways	SMP0000306	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Isoprenaline Action Pathway	SMPDB pathways	SMP0000663	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Betaxolol Action Pathway	SMPDB pathways	SMP0000299	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Muscle/Heart Contraction	SMPDB pathways	SMP0000588	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Nifedipine Action Pathway	SMPDB pathways	SMP0000379	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Carteolol Action Pathway	SMPDB pathways	SMP0000658	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Ibutilide Action Pathway	SMPDB pathways	SMP0000332	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Propranolol Action Pathway	SMPDB pathways	SMP0000307	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Bupranolol Action Pathway	SMPDB pathways	SMP0000670	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Amiodarone Action Pathway	SMPDB pathways	SMP0000665	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Dobutamine Action Pathway	SMPDB pathways	SMP0000662	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Arbutamine Action Pathway	SMPDB pathways	SMP0000664	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Sotalol Action Pathway	SMPDB pathways	SMP0000660	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Practolol Action Pathway	SMPDB pathways	SMP0000669	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Quinidine Action Pathway	SMPDB pathways	SMP0000323	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Epinephrine Action Pathway	SMPDB pathways	SMP0000661	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Bevantolol Action Pathway	SMPDB pathways	SMP0000668	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Nadolol Action Pathway	SMPDB pathways	SMP0000303	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Levobunolol Action Pathway	SMPDB pathways	SMP0000666	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Nebivolol Action Pathway	SMPDB pathways	SMP0000366	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Metipranolol Action Pathway	SMPDB pathways	SMP0000667	57	2	1369	6	PLCB1,ATP1A2
2.306e-02	-3.77	synovial	COSMIC cancer mutations	synovial	8	1	16828	49	CNTN1
2.306e-02	-3.77	bone-knee-chondrosarcoma-synovial	COSMIC cancer mutations	bone-knee-chondrosarcoma-synovial	8	1	16828	49	CNTN1
2.315e-02	-3.77	regulation of apoptotic signaling pathway	biological process	GO:2001233	396	4	18204	50	CLU,EYA2,BMPR1B,FYN
2.318e-02	-3.76	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	3	16828	49	LRP1B,TSHZ2,SLC7A11
2.331e-02	-3.76	flotillin complex	cellular component	GO:0016600	9	1	19108	50	SORBS1
2.331e-02	-3.76	astrocyte end-foot	cellular component	GO:0097450	9	1	19108	50	AQP4
2.334e-02	-3.76	transport across blood-brain barrier	biological process	GO:0150104	86	2	18204	50	SLC1A2,ATP1A2
2.334e-02	-3.76	vascular transport	biological process	GO:0010232	86	2	18204	50	SLC1A2,ATP1A2
2.334e-02	-3.76	central nervous system neuron development	biological process	GO:0021954	86	2	18204	50	DCLK2,NTRK2
2.335e-02	-3.76	Lipoprotein metabolism	REACTOME pathways	R-HSA-174824	74	2	10285	33	ABCA1,FYN
2.344e-02	-3.75	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	47	NEBL,ABLIM1
2.366e-02	-3.74	TRAF6 (TNF receptor associated factor 6)	protein interactions	7189	426	4	19454	50	MAP3K5,FYN,NTRK2,BMPR1B
2.371e-02	-3.74	Labetalol Action Pathway	SMPDB pathways	SMP0000368	58	2	1369	6	PLCB1,ATP1A2
2.371e-02	-3.74	Carvedilol Action Pathway	SMPDB pathways	SMP0000367	58	2	1369	6	PLCB1,ATP1A2
2.384e-02	-3.74	associative learning	biological process	GO:0008306	87	2	18204	50	SLC7A11,ATP1A2
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	BMPR1B,ABLIM1
2.387e-02	-3.74	DMRTB1 (DMRT like family B with proline rich C-terminal 1)	protein interactions	63948	93	2	19454	50	EYA2,MSI2
2.387e-02	-3.74	MPDZ (multiple PDZ domain crumbs cell polarity complex component)	protein interactions	8777	93	2	19454	50	PARD3,ABCA1
2.387e-02	-3.74	TRAF5 (TNF receptor associated factor 5)	protein interactions	7188	93	2	19454	50	AHCYL1,MAP3K5
2.402e-02	-3.73	Activin_recp	pfam domains	PF01064	9	1	17795	48	BMPR1B
2.402e-02	-3.73	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	48	RFX4
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	Doublecortin_dom	interpro domains	IPR003533	9	1	18521	50	DCLK2
2.428e-02	-3.72	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	24	PRKCA,NRG3
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CTNND2,CLU
2.435e-02	-3.72	AKAP17A (A-kinase anchoring protein 17A)	protein interactions	8227	94	2	19454	50	AHCYL1,TRPM3
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	ABLIM1,PRKCA
2.435e-02	-3.72	DUSP1 (dual specificity phosphatase 1)	protein interactions	1843	94	2	19454	50	EYA2,MAPK10
2.445e-02	-3.71	GAS2	smart domains	SM00243	6	1	9717	40	MACF1
2.446e-02	-3.71	regulation of mRNA 3'-end processing	biological process	GO:0031440	9	1	18204	50	AHCYL1
2.446e-02	-3.71	macrophage proliferation	biological process	GO:0061517	9	1	18204	50	CLU
2.446e-02	-3.71	microglial cell proliferation	biological process	GO:0061518	9	1	18204	50	CLU
2.446e-02	-3.71	interleukin-12-mediated signaling pathway	biological process	GO:0035722	9	1	18204	50	PLCB1
2.446e-02	-3.71	tripeptide transmembrane transport	biological process	GO:0035443	9	1	18204	50	SLC7A11
2.446e-02	-3.71	intracellular amino acid homeostasis	biological process	GO:0080144	9	1	18204	50	SLC7A11
2.446e-02	-3.71	glutathione transport	biological process	GO:0034635	9	1	18204	50	SLC7A11
2.446e-02	-3.71	negative regulation of cellular extravasation	biological process	GO:0002692	9	1	18204	50	PLCB1
2.446e-02	-3.71	activated T cell proliferation	biological process	GO:0050798	9	1	18204	50	FYN
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.446e-02	-3.71	mitochondrial outer membrane permeabilization	biological process	GO:0097345	9	1	18204	50	EYA2
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.450e-02	-3.71	Lidocaine (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000328	59	2	1369	6	ATP1A2,PLCB1
2.454e-02	-3.71	Cell death signalling via NRAGE, NRIF and NADE	REACTOME pathways	R-HSA-204998	76	2	10285	33	ARHGEF4,KALRN
2.455e-02	-3.71	Neuronal System	REACTOME pathways	R-HSA-112316	349	4	10285	33	PRKCA,SLC1A2,ADCY2,PLCB1
2.460e-02	-3.70	calcium-dependent protein serine/threonine kinase activity	molecular function	GO:0009931	9	1	18094	50	PRKCA
2.460e-02	-3.70	phosphatidylserine floppase activity	molecular function	GO:0090556	9	1	18094	50	ABCA1
2.468e-02	-3.70	cellular response to oxidative stress	biological process	GO:0034599	228	3	18204	50	MAP3K5,FYN,SLC7A11
2.470e-02	-3.70	EGF-like_dom	interpro domains	IPR000742	232	3	18521	50	LRP1B,EFEMP1,NRG3
2.487e-02	-3.69	cellular response to amino acid stimulus	biological process	GO:0071230	89	2	18204	50	FYN,NTRK2
2.500e-02	-3.69	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	3	7161	28	ATP1A2,ADCY2,PLCB1
2.500e-02	-3.69	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	3	7161	28	ADCY2,ATP1A2,PLCB1
2.504e-02	-3.69	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	MAP3K5,NTRK2,PRKCA,FYN
2.504e-02	-3.69	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	4	16828	49	MAP3K5,FYN,NTRK2,PRKCA
2.504e-02	-3.69	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	4	16828	49	NTRK2,PRKCA,FYN,MAP3K5
2.504e-02	-3.69	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	FYN,PRKCA,NTRK2,MAP3K5
2.504e-02	-3.69	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	MAP3K5,FYN,NTRK2,PRKCA
2.507e-02	-3.69	magnesium ion binding	molecular function	GO:0000287	228	3	18094	50	ADCY2,EYA2,MAP3K5
2.513e-02	-3.68	Pathogenic Escherichia coli infection	WikiPathways	WP2272	55	2	5310	24	FYN,PRKCA
2.518e-02	-3.68	EDTRNSPORT	prints domains	PR00173	7	1	5227	19	SLC1A2
2.523e-02	-3.68	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	3	16828	49	DTNA,RFX4,PLCB1
2.532e-02	-3.68	SOCS2 (suppressor of cytokine signaling 2)	protein interactions	8835	96	2	19454	50	NTRK2,SLC7A11
2.534e-02	-3.68	regulation of intracellular signal transduction	biological process	GO:1902531	1832	10	18204	50	FYN,MAP3K5,PRKCA,PLCB1,ARHGEF4,RORA,KALRN,NTRK2,ABCA1,CLU
2.539e-02	-3.67	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME pathways	R-HSA-434316	8	1	10285	33	PLCB1
2.539e-02	-3.67	Nef and signal transduction	REACTOME pathways	R-HSA-164944	8	1	10285	33	FYN
2.539e-02	-3.67	Free fatty acids regulate insulin secretion	REACTOME pathways	R-HSA-400451	8	1	10285	33	PLCB1
2.539e-02	-3.67	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	33	GPC5
2.539e-02	-3.67	HuR (ELAVL1) binds and stabilizes mRNA	REACTOME pathways	R-HSA-450520	8	1	10285	33	PRKCA
2.539e-02	-3.67	feeding behavior	biological process	GO:0007631	90	2	18204	50	FYN,NTRK2
2.541e-02	-3.67	FCER2 (Fc epsilon receptor II)	protein interactions	2208	10	1	19454	50	FYN
2.541e-02	-3.67	PPY (pancreatic polypeptide)	protein interactions	5539	10	1	19454	50	PRKCA
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	CLDN20 (claudin 20)	protein interactions	49861	10	1	19454	50	FYN
2.541e-02	-3.67	ZNF563 (zinc finger protein 563)	protein interactions	147837	10	1	19454	50	LRP1B
2.541e-02	-3.67	TMEM204 (transmembrane protein 204)	protein interactions	79652	10	1	19454	50	FYN
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	CHRDL1 (chordin like 1)	protein interactions	91851	10	1	19454	50	LRP1B
2.541e-02	-3.67	TSHZ1 (teashirt zinc finger homeobox 1)	protein interactions	10194	10	1	19454	50	TSHZ2
2.541e-02	-3.67	GAB3 (GRB2 associated binding protein 3)	protein interactions	139716	10	1	19454	50	FYN
2.541e-02	-3.67	TNP1 (transition protein 1)	protein interactions	7141	10	1	19454	50	PRKCA
2.541e-02	-3.67	AOX1 (aldehyde oxidase 1)	protein interactions	316	10	1	19454	50	ABCA1
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.544e-02	-3.67	cell leading edge	cellular component	GO:0031252	428	4	19108	50	SLC1A2,ARHGEF4,MACF1,ABLIM1
2.544e-02	-3.67	collagen-containing extracellular matrix	cellular component	GO:0062023	428	4	19108	50	GPC5,EFEMP1,PTPRZ1,CLU
2.551e-02	-3.67	CCDC8 (coiled-coil domain containing 8)	protein interactions	83987	652	5	19454	50	NTRK2,PRKCA,ABLIM1,MACF1,FYN
2.557e-02	-3.67	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	1	12186	45	SLC1A2
2.557e-02	-3.67	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	1	12186	45	SLC1A2
2.557e-02	-3.67	GS	prosite domains	PS51256	7	1	12186	45	BMPR1B
2.568e-02	-3.66	spindle	COSMIC cancer mutations	spindle	386	4	16828	49	KALRN,CTNND2,MACF1,TRPM3
2.570e-02	-3.66	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	47	ABLIM1
2.581e-02	-3.66	PLCB3 (phospholipase C beta 3)	protein interactions	5331	97	2	19454	50	PLCB1,PARD3
2.581e-02	-3.66	SNTA1 (syntrophin alpha 1)	protein interactions	6640	97	2	19454	50	ABCA1,DTNA
2.581e-02	-3.66	LIN7C (lin-7 homolog C, crumbs cell polarity complex component)	protein interactions	55327	97	2	19454	50	ABCA1,ABLIM1
2.587e-02	-3.65	perineuronal net	cellular component	GO:0072534	10	1	19108	50	PTPRZ1
2.597e-02	-3.65	response to cytokine	biological process	GO:0034097	834	6	18204	50	MAP3K5,PRKCA,ABCA1,PLCB1,AQP4,RORA
2.606e-02	-3.65	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	WikiPathways	WP2380	144	3	5310	24	FYN,NTRK2,MAPK10
2.606e-02	-3.65	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	6	ADCY2
2.606e-02	-3.65	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	6	ADCY2
2.631e-02	-3.64	DACH1 (dachshund family transcription factor 1)	protein interactions	1602	98	2	19454	50	AHCYL1,SOX5
2.631e-02	-3.64	PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2)	protein interactions	5636	98	2	19454	50	PRKCA,FYN
2.631e-02	-3.64	DMD (dystrophin)	protein interactions	1756	98	2	19454	50	DTNA,MAP3K5
2.649e-02	-3.63	chromatin	cellular component	GO:0000785	1387	8	19108	50	RFX4,PLCB1,NPAS3,TRPS1,HIF3A,TSHZ2,SOX5,RORA
2.654e-02	-3.63	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	49	PLCB1,LRP1B,MAP3K5,FMN2,PARD3B
2.666e-02	-3.62	MIR	pfam domains	PF02815	10	1	17795	48	RYR3
2.666e-02	-3.62	PAS_3	pfam domains	PF08447	10	1	17795	48	NPAS3
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	Doublecortin_dom_sf	interpro domains	IPR036572	10	1	18521	50	DCLK2
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.668e-02	-3.62	MIP_CS	interpro domains	IPR022357	10	1	18521	50	AQP4
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.676e-02	-3.62	inorganic cation transmembrane transport	biological process	GO:0098662	618	5	18204	50	TRPM3,GPM6A,ATP1A2,PLCB1,RYR3
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	SOX5,TRPS1
2.680e-02	-3.62	PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1)	protein interactions	5635	99	2	19454	50	FYN,PRKCA
2.680e-02	-3.62	Flnb (filamin, beta)	protein interactions	286940	99	2	19454	50	ABLIM1,FYN
2.699e-02	-3.61	regulation of extent of cell growth	biological process	GO:0061387	93	2	18204	50	MACF1,NRCAM
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	50	NRG3
2.714e-02	-3.61	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	50	ABCA1
2.714e-02	-3.61	desmosome organization	biological process	GO:0002934	10	1	18204	50	PRKCA
2.714e-02	-3.61	negative regulation of glial cell apoptotic process	biological process	GO:0034351	10	1	18204	50	PRKCA
2.714e-02	-3.61	positive regulation of lipopolysaccharide-mediated signaling pathway	biological process	GO:0031666	10	1	18204	50	PRKCA
2.714e-02	-3.61	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	50	ADCY2
2.714e-02	-3.61	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	50	NTRK2
2.714e-02	-3.61	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	50	NRG3
2.714e-02	-3.61	retinal rod cell development	biological process	GO:0046548	10	1	18204	50	NTRK2
2.714e-02	-3.61	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	50	NTRK2
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	cellular response to cocaine	biological process	GO:0071314	10	1	18204	50	SLC1A2
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	NTRK2,FYN
2.719e-02	-3.60	EGF-type_Asp/Asn_hydroxyl_site	interpro domains	IPR000152	95	2	18521	50	LRP1B,EFEMP1
2.730e-02	-3.60	calcium-dependent protein kinase activity	molecular function	GO:0010857	10	1	18094	50	PRKCA
2.730e-02	-3.60	G protein-coupled glutamate receptor binding	molecular function	GO:0035256	10	1	18094	50	FYN
2.730e-02	-3.60	neurotrophin binding	molecular function	GO:0043121	10	1	18094	50	NTRK2
2.730e-02	-3.60	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	50	PITPNC1
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	GPM6A,ATP1A2
2.731e-02	-3.60	EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2)	protein interactions	55741	100	2	19454	50	HPSE2,CLU
2.735e-02	-3.60	RHOG (ras homolog family member G)	protein interactions	391	902	6	19454	50	AHCYL1,SLC7A11,FMN2,DTNA,MACF1,PARD3
2.737e-02	-3.60	pancreas-other-adenoma	COSMIC cancer mutations	pancreas-other-adenoma	224	3	16828	49	CTNND2,BMPR1B,PRKCA
2.747e-02	-3.59	DH_2	prosite domains	PS50010	70	2	12186	45	KALRN,ARHGEF4
2.756e-02	-3.59	muscle contraction	biological process	GO:0006936	238	3	18204	50	DTNA,ATP1A2,RYR3
2.763e-02	-3.59	RAC2 (Rac family small GTPase 2)	protein interactions	5880	666	5	19454	50	MACF1,PARD3,FYN,AHCYL1,SLC7A11
2.769e-02	-3.59	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	3	16828	49	PLCB1,RFX4,DTNA
2.771e-02	-3.59	microvillus	cellular component	GO:0005902	99	2	19108	50	SLC7A11,FMN2
2.772e-02	-3.59	EGF_Ca-bd_CS	interpro domains	IPR018097	96	2	18521	50	LRP1B,EFEMP1
2.781e-02	-3.58	PRKCG (protein kinase C gamma)	protein interactions	5582	101	2	19454	50	PARD3,PRKCA
2.787e-02	-3.58	Tight junction	KEGG pathways	hsa04530	170	3	7161	28	MAPK10,PARD3,MAP3K5
2.787e-02	-3.58	Tight junction	KEGG pathways	ko04530	170	3	7161	28	MAP3K5,PARD3,MAPK10
2.788e-02	-3.58	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	28	PRKCA,PLCB1
2.788e-02	-3.58	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	28	PRKCA,PLCB1
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	ITPKA (inositol-trisphosphate 3-kinase A)	protein interactions	3706	11	1	19454	50	PRKCA
2.792e-02	-3.58	TMEM53 (transmembrane protein 53)	protein interactions	79639	11	1	19454	50	PRKCA
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	NPPC (natriuretic peptide C)	protein interactions	4880	11	1	19454	50	EYA2
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	SCN3A (sodium voltage-gated channel alpha subunit 3)	protein interactions	6328	11	1	19454	50	CNTN1
2.804e-02	-3.57	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	43	16828	49	AHCYL1,NRG3,MSI2,GPM6A,PLCB1,NEBL,SOX5,DCLK2,PARD3B,RORA,CNTN1,SLC7A11,GLIS3,SLC1A2,LRP1B,ABCA1,KALRN,ATP1A2,NTRK2,LSAMP,PRKCA,GPC5,HPSE2,ARHGEF4,ABLIM1,TRPM3,MACF1,CTNND2,TSHZ2,AQP4,RFX4,TRPS1,CLU,FMN2,FYN,BMPR1B,EYA2,EFEMP1,MAP3K5,SORBS1,PARD3,ADCY2,RYR3
2.807e-02	-3.57	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	50	PLCB1,RYR3
2.820e-02	-3.57	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	45	NEBL,ABLIM1
2.820e-02	-3.57	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	45	ABLIM1,NEBL
2.828e-02	-3.57	Immunoglobulins	gene3d domains	2.60.40.10	721	6	14470	47	CNTN1,NTRK2,PTPRZ1,KALRN,NRCAM,LSAMP
2.832e-02	-3.56	PDLIM7 (PDZ and LIM domain 7)	protein interactions	9260	257	3	19454	50	ABLIM1,PRKCA,PARD3
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.832e-02	-3.56	FASLG (Fas ligand)	protein interactions	356	102	2	19454	50	FYN,KALRN
2.832e-02	-3.56	ZSCAN21 (zinc finger and SCAN domain containing 21)	protein interactions	7589	102	2	19454	50	LRP1B,EFEMP1
2.832e-02	-3.56	KRTAP6-1 (keratin associated protein 6-1)	protein interactions	337966	102	2	19454	50	EFEMP1,GLIS3
2.832e-02	-3.56	CACNA1A (calcium voltage-gated channel subunit alpha1 A)	protein interactions	773	102	2	19454	50	KALRN,EFEMP1
2.834e-02	-3.56	nucleotide binding	molecular function	GO:0000166	2128	11	18094	50	ADCY2,ATP1A2,ABCA1,MAP3K5,BMPR1B,KALRN,FYN,PRKCA,DCLK2,MAPK10,NTRK2
2.838e-02	-3.56	response to radiation	biological process	GO:0009314	422	4	18204	50	SLC1A2,SLC7A11,ATP1A2,MAPK10
2.842e-02	-3.56	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	50	PTPRZ1
2.843e-02	-3.56	nucleoside phosphate binding	molecular function	GO:1901265	2129	11	18094	50	MAPK10,NTRK2,PRKCA,DCLK2,KALRN,FYN,MAP3K5,BMPR1B,ATP1A2,ADCY2,ABCA1
2.847e-02	-3.56	GS	smart domains	SM00467	7	1	9717	40	BMPR1B
2.847e-02	-3.56	PLEC	smart domains	SM00250	7	1	9717	40	MACF1
2.852e-02	-3.56	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	33	CLU
2.852e-02	-3.56	EGFR Transactivation by Gastrin	REACTOME pathways	R-HSA-2179392	9	1	10285	33	PRKCA
2.865e-02	-3.55	Epithelial cell signaling in Helicobacter pylori infection	KEGG pathways	hsa05120	68	2	7161	28	MAPK10,PTPRZ1
2.865e-02	-3.55	Epithelial cell signaling in Helicobacter pylori infection	KEGG pathways	ko05120	68	2	7161	28	PTPRZ1,MAPK10
2.873e-02	-3.55	GATAZNFINGER	prints domains	PR00619	8	1	5227	19	TRPS1
2.875e-02	-3.55	ruffle membrane	cellular component	GO:0032587	101	2	19108	50	ARHGEF4,MACF1
2.884e-02	-3.55	ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)	protein interactions	25921	103	2	19454	50	PARD3,NTRK2
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	GPM6A,BMPR1B
2.885e-02	-3.55	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	33	ATP1A2,RYR3,TRPM3
2.885e-02	-3.55	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	91	2	16828	49	ADCY2,LRP1B
2.886e-02	-3.55	Doublecortin domain	gene3d domains	3.10.20.230	9	1	14470	47	DCLK2
2.889e-02	-3.54	MARK2 (microtubule affinity regulating kinase 2)	protein interactions	2011	259	3	19454	50	PARD3B,PARD3,DTNA
2.894e-02	-3.54	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	50	ATP1A2,ABCA1
2.900e-02	-3.54	craniopharyngeal_duct	COSMIC cancer mutations	craniopharyngeal_duct	401	4	16828	49	RYR3,PTPRZ1,NRCAM,PARD3
2.900e-02	-3.54	craniopharyngioma	COSMIC cancer mutations	craniopharyngioma	401	4	16828	49	PTPRZ1,RYR3,NRCAM,PARD3
2.917e-02	-3.53	positive regulation of JNK cascade	biological process	GO:0046330	97	2	18204	50	MAP3K5,PLCB1
2.917e-02	-3.53	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	50	SLC7A11,SLC1A2
2.917e-02	-3.53	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	45	TRPS1
2.917e-02	-3.53	HP	prosite domains	PS51089	8	1	12186	45	ABLIM1
2.920e-02	-3.53	FGFR4 (fibroblast growth factor receptor 4)	protein interactions	2264	455	4	19454	50	SORBS1,MAP3K5,AHCYL1,ABLIM1
2.928e-02	-3.53	PAS_11	pfam domains	PF14598	11	1	17795	48	HIF3A
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.936e-02	-3.53	GRK2 (G protein-coupled receptor kinase 2)	protein interactions	156	104	2	19454	50	PRKCA,PLCB1
2.936e-02	-3.53	MFHAS1 (multifunctional ROCO family signaling regulator 1)	protein interactions	9258	104	2	19454	50	AHCYL1,ABLIM1
2.937e-02	-3.53	regulation of neuron apoptotic process	biological process	GO:0043523	244	3	18204	50	NTRK2,CLU,PTPRZ1
2.937e-02	-3.53	negative regulation of apoptotic signaling pathway	biological process	GO:2001234	244	3	18204	50	FYN,CLU,EYA2
2.940e-02	-3.53	RELA (RELA proto-oncogene, NF-kB subunit)	protein interactions	5970	456	4	19454	50	MAPK10,ABCA1,AHCYL1,SLC1A2
2.942e-02	-3.53	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	5	18094	50	ATP1A2,TRPM3,SLC1A2,RYR3,GPM6A
2.946e-02	-3.52	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	24	PRKCA,ADCY2,RYR3
2.955e-02	-3.52	Kit receptor signaling pathway	WikiPathways	WP304	60	2	5310	24	PRKCA,FYN
2.958e-02	-3.52	VIRMA (vir like m6A methyltransferase associated)	protein interactions	25962	2914	13	19454	50	KALRN,PARD3,PRKCA,PLCB1,TSHZ2,MAP3K5,MACF1,ABLIM1,PARD3B,CLU,SORBS1,TRPS1,NRCAM
2.971e-02	-3.52	response to abiotic stimulus	biological process	GO:0009628	1100	7	18204	50	SLC7A11,FMN2,SLC1A2,RORA,MAPK10,ATP1A2,FYN
2.972e-02	-3.52	response to hydrogen peroxide	biological process	GO:0042542	98	2	18204	50	FYN,MAP3K5
2.972e-02	-3.52	cellular response to acid chemical	biological process	GO:0071229	98	2	18204	50	FYN,NTRK2
2.980e-02	-3.51	organic substance transport	biological process	GO:0071702	1881	10	18204	50	AHCYL1,LRP1B,PITPNC1,SLC7A11,MACF1,CLU,NTRK2,ABCA1,FMN2,SLC1A2
2.980e-02	-3.51	monoatomic cation transmembrane transport	biological process	GO:0098655	636	5	18204	50	PLCB1,RYR3,ATP1A2,GPM6A,TRPM3
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.981e-02	-3.51	negative regulation of cholesterol storage	biological process	GO:0010887	11	1	18204	50	ABCA1
2.981e-02	-3.51	cellular response to interleukin-12	biological process	GO:0071349	11	1	18204	50	PLCB1
2.981e-02	-3.51	endothelial cell apoptotic process	biological process	GO:0072577	11	1	18204	50	MAP3K5
2.981e-02	-3.51	positive regulation of acrosome reaction	biological process	GO:2000344	11	1	18204	50	PLCB1
2.981e-02	-3.51	L-aspartate transmembrane transport	biological process	GO:0070778	11	1	18204	50	SLC1A2
2.981e-02	-3.51	cellular response to interleukin-15	biological process	GO:0071350	11	1	18204	50	PLCB1
2.981e-02	-3.51	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	50	NRG3
2.981e-02	-3.51	tripeptide transport	biological process	GO:0042939	11	1	18204	50	SLC7A11
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.981e-02	-3.51	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	50	BMPR1B
2.981e-02	-3.51	pyramidal neuron development	biological process	GO:0021860	11	1	18204	50	DCLK2
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	interleukin-15-mediated signaling pathway	biological process	GO:0035723	11	1	18204	50	PLCB1
2.981e-02	-3.51	glutamate secretion	biological process	GO:0014047	11	1	18204	50	NTRK2
2.981e-02	-3.51	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	50	NRG3
2.981e-02	-3.51	ectodermal placode formation	biological process	GO:0060788	11	1	18204	50	NRG3
2.981e-02	-3.51	egg activation	biological process	GO:0007343	11	1	18204	50	PLCB1
2.981e-02	-3.51	dendritic spine maintenance	biological process	GO:0097062	11	1	18204	50	FYN
2.984e-02	-3.51	cell motility	biological process	GO:0048870	1101	7	18204	50	GPC5,FMN2,NTRK2,GPM6A,NRCAM,FYN,NRG3
2.988e-02	-3.51	ANP32E (acidic nuclear phosphoprotein 32 family member E)	protein interactions	81611	105	2	19454	50	AHCYL1,PARD3
2.988e-02	-3.51	ZNF444 (zinc finger protein 444)	protein interactions	55311	105	2	19454	50	AHCYL1,EFEMP1
2.999e-02	-3.51	histone H3 kinase activity	molecular function	GO:0140996	11	1	18094	50	PRKCA
2.999e-02	-3.51	JUN kinase kinase kinase activity	molecular function	GO:0004706	11	1	18094	50	MAP3K5
2.999e-02	-3.51	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	50	NTRK2,PTPRZ1,MACF1
3.003e-02	-3.51	aldosterone_producing	COSMIC cancer mutations	aldosterone_producing	93	2	16828	49	LRP1B,ADCY2
3.013e-02	-3.50	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	4	10285	33	AHCYL1,FYN,NRG3,MAPK10
3.028e-02	-3.50	phospholipid transport	biological process	GO:0015914	99	2	18204	50	PITPNC1,ABCA1
3.034e-02	-3.50	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	6	ADCY2
3.034e-02	-3.50	g-Secretase Mediated ErbB4 Signalling Pathway	SMPDB pathways	SMP0089975	7	1	1369	6	PRKCA
3.034e-02	-3.50	G-Protein Signaling Through Tubby Proteins	SMPDB pathways	SMP0089843	7	1	1369	6	PLCB1
3.036e-02	-3.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	5	19454	50	AHCYL1,PLCB1,SLC7A11,FMN2,MACF1
3.040e-02	-3.49	ATXN7 (ataxin 7)	protein interactions	6314	106	2	19454	50	KALRN,EFEMP1
3.040e-02	-3.49	USP6NL (USP6 N-terminal like)	protein interactions	9712	106	2	19454	50	PARD3,NTRK2
3.042e-02	-3.49	XK (X-linked Kx blood group antigen, Kell and VPS13A binding protein)	protein interactions	7504	12	1	19454	50	PRKCA
3.042e-02	-3.49	Pard6b (par-6 family cell polarity regulator beta)	protein interactions	58220	12	1	19454	50	PARD3
3.042e-02	-3.49	KIF26A (kinesin family member 26A)	protein interactions	26153	12	1	19454	50	MAPK10
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	Ctnnbl1 (catenin, beta like 1)	protein interactions	66642	12	1	19454	50	PRKCA
3.042e-02	-3.49	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	50	CLU
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	NPY4R (neuropeptide Y receptor Y4)	protein interactions	5540	12	1	19454	50	MAP3K5
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	PROK2 (prokineticin 2)	protein interactions	60675	12	1	19454	50	LRP1B
3.085e-02	-3.48	response to alkaloid	biological process	GO:0043279	100	2	18204	50	SLC1A2,RYR3
3.086e-02	-3.48	Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME pathways	R-HSA-2029480	86	2	10285	33	FYN,AHCYL1
3.093e-02	-3.48	EPHA3 (EPH receptor A3)	protein interactions	2042	107	2	19454	50	PARD3,FYN
3.093e-02	-3.48	APLP2 (amyloid beta precursor like protein 2)	protein interactions	334	107	2	19454	50	HPSE2,PRKCA
3.093e-02	-3.48	SPR (sepiapterin reductase)	protein interactions	6697	107	2	19454	50	AHCYL1,FYN
3.093e-02	-3.48	ERRFI1 (ERBB receptor feedback inhibitor 1)	protein interactions	54206	107	2	19454	50	EFEMP1,FYN
3.096e-02	-3.48	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	50	ATP1A2
3.096e-02	-3.48	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	50	PTPRZ1
3.116e-02	-3.47	DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	GO:0000981	1355	8	18094	50	RORA,SOX5,HIF3A,RFX4,GLIS3,NPAS3,TSHZ2,TRPS1
3.119e-02	-3.47	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	50	SLC1A2,SLC7A11
3.119e-02	-3.47	protein tyrosine phosphatase activity	molecular function	GO:0004725	100	2	18094	50	PTPRZ1,EYA2
3.125e-02	-3.47	cellular response to peptide hormone stimulus	biological process	GO:0071375	250	3	18204	50	AHCYL1,SORBS1,PLCB1
3.139e-02	-3.46	regulation of protein localization	biological process	GO:0032880	872	6	18204	50	GPC5,SLC7A11,SORBS1,DCLK2,PLCB1,FYN
3.142e-02	-3.46	cholesterol homeostasis	biological process	GO:0042632	101	2	18204	50	RORA,ABCA1
3.142e-02	-3.46	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	50	SORBS1,RORA
3.147e-02	-3.46	HSP90AA4P (heat shock protein 90 alpha family class A member 4, pseudogene)	protein interactions	3323	108	2	19454	50	FYN,DTNA
3.147e-02	-3.46	CLASP1 (cytoplasmic linker associated protein 1)	protein interactions	23332	108	2	19454	50	MACF1,DCLK2
3.147e-02	-3.46	EN1 (engrailed homeobox 1)	protein interactions	2019	108	2	19454	50	AHCYL1,TRPS1
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	MSI2,RYR3
3.147e-02	-3.46	CAMKV (CaM kinase like vesicle associated)	protein interactions	79012	108	2	19454	50	AHCYL1,GPM6A
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	GPM6A,CLU
3.147e-02	-3.46	UFM1 (ubiquitin fold modifier 1)	protein interactions	51569	108	2	19454	50	MSI2,AHCYL1
3.152e-02	-3.46	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	33	NRG3,FYN
3.164e-02	-3.45	Netrin mediated repulsion signals	REACTOME pathways	R-HSA-418886	10	1	10285	33	FYN
3.164e-02	-3.45	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	33	ADCY2
3.164e-02	-3.45	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	33	NRG3
3.164e-02	-3.45	Activation of the AP-1 family of transcription factors	REACTOME pathways	R-HSA-450341	10	1	10285	33	MAPK10
3.173e-02	-3.45	RhoGEF	smart domains	SM00325	68	2	9717	40	ARHGEF4,KALRN
3.181e-02	-3.45	RND3 (Rho family GTPase 3)	protein interactions	390	269	3	19454	50	AHCYL1,SLC7A11,PARD3
3.190e-02	-3.45	EF-hand_like	pfam domains	PF09279	12	1	17795	48	PLCB1
3.190e-02	-3.45	ABC2_membrane_3	pfam domains	PF12698	12	1	17795	48	ABCA1
3.193e-02	-3.44	MAP_kinase_CS	interpro domains	IPR003527	12	1	18521	50	MAPK10
3.193e-02	-3.44	ABCA	interpro domains	IPR026082	12	1	18521	50	ABCA1
3.193e-02	-3.44	PLC_EF-hand-like	interpro domains	IPR015359	12	1	18521	50	PLCB1
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.199e-02	-3.44	sterol homeostasis	biological process	GO:0055092	102	2	18204	50	RORA,ABCA1
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	TRPM3,SOX5
3.200e-02	-3.44	NOS1AP (nitric oxide synthase 1 adaptor protein)	protein interactions	9722	109	2	19454	50	NTRK2,FYN
3.200e-02	-3.44	MBP (myelin basic protein)	protein interactions	4155	109	2	19454	50	PRKCA,MAP3K5
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	SORBS1,ADCY2,DTNA,RFX4,CLU,FMN2,PTPRZ1,FYN,ARHGEF4,GPC5,CTNND2,ABCA1,SLC1A2,LSAMP,PRKCA,RORA,NRCAM,GLIS3,CNTN1,SLC7A11,NEBL,NRG3,MSI2,PARD3,MAP3K5,EFEMP1,RYR3,EYA2,TRPS1,NPAS3,AQP4,BMPR1B,ABLIM1,HPSE2,TSHZ2,TRPM3,MACF1,LRP1B,ATP1A2,NTRK2,HIF3A,DCLK2,SOX5,PARD3B,PLCB1,PITPNC1,AHCYL1,GPM6A
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	DTNA,SORBS1,ADCY2,CTNND2,ARHGEF4,GPC5,PTPRZ1,FYN,FMN2,RFX4,CLU,GLIS3,SLC7A11,CNTN1,NRCAM,RORA,PRKCA,LSAMP,ABCA1,SLC1A2,MSI2,NRG3,NEBL,EYA2,RYR3,PARD3,MAP3K5,EFEMP1,TSHZ2,TRPM3,MACF1,ABLIM1,HPSE2,BMPR1B,TRPS1,AQP4,NPAS3,HIF3A,NTRK2,LRP1B,ATP1A2,GPM6A,AHCYL1,PITPNC1,PARD3B,DCLK2,SOX5,PLCB1
3.219e-02	-3.44	G alpha (12/13) signalling events	REACTOME pathways	R-HSA-416482	88	2	10285	33	ARHGEF4,KALRN
3.227e-02	-3.43	NAKATPASE	prints domains	PR00121	9	1	5227	19	ATP1A2
3.241e-02	-3.43	GNB1 (G protein subunit beta 1)	protein interactions	2782	271	3	19454	50	KALRN,NTRK2,FYN
3.247e-02	-3.43	VHP	smart domains	SM00153	8	1	9717	40	ABLIM1
3.248e-02	-3.43	response to interleukin-15	biological process	GO:0070672	12	1	18204	50	PLCB1
3.248e-02	-3.43	regulation of glial cell apoptotic process	biological process	GO:0034350	12	1	18204	50	PRKCA
3.248e-02	-3.43	oligopeptide transmembrane transport	biological process	GO:0035672	12	1	18204	50	SLC7A11
3.248e-02	-3.43	response to interleukin-12	biological process	GO:0070671	12	1	18204	50	PLCB1
3.248e-02	-3.43	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	50	BMPR1B
3.248e-02	-3.43	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	50	BMPR1B
3.248e-02	-3.43	nuclear membrane disassembly	biological process	GO:0051081	12	1	18204	50	PRKCA
3.248e-02	-3.43	epithelial fluid transport	biological process	GO:0042045	12	1	18204	50	AHCYL1
3.248e-02	-3.43	neuronal ion channel clustering	biological process	GO:0045161	12	1	18204	50	NRCAM
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	BMPR1B,PARD3B
3.254e-02	-3.43	HOXB5 (homeobox B5)	protein interactions	3215	110	2	19454	50	CNTN1,FYN
3.254e-02	-3.43	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	2	19454	50	PRKCA,FYN
3.257e-02	-3.42	cerebellum development	biological process	GO:0021549	103	2	18204	50	CNTN1,RORA
3.267e-02	-3.42	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	50	ADCY2
3.267e-02	-3.42	protein binding involved in heterotypic cell-cell adhesion	molecular function	GO:0086080	12	1	18094	50	NRCAM
3.276e-02	-3.42	RFX_DBD	prosite domains	PS51526	9	1	12186	45	RFX4
3.276e-02	-3.42	DC	prosite domains	PS50309	9	1	12186	45	DCLK2
3.291e-02	-3.41	RNASE4 (ribonuclease A family member 4)	protein interactions	6038	13	1	19454	50	LRP1B
3.291e-02	-3.41	KCNQ2 (potassium voltage-gated channel subfamily Q member 2)	protein interactions	3785	13	1	19454	50	PRKCA
3.291e-02	-3.41	ACBD7 (acyl-CoA binding domain containing 7)	protein interactions	414149	13	1	19454	50	FYN
3.291e-02	-3.41	JAM2 (junctional adhesion molecule 2)	protein interactions	58494	13	1	19454	50	PARD3
3.291e-02	-3.41	IL23R (interleukin 23 receptor)	protein interactions	149233	13	1	19454	50	PRKCA
3.291e-02	-3.41	DDIAS (DNA damage induced apoptosis suppressor)	protein interactions	220042	13	1	19454	50	EFEMP1
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.309e-02	-3.41	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	3	5310	24	RYR3,ADCY2,PRKCA
3.320e-02	-3.41	Chemokine signaling pathway	KEGG pathways	ko04062	182	3	7161	28	ADCY2,PARD3,PLCB1
3.320e-02	-3.41	Chemokine signaling pathway	KEGG pathways	hsa04062	182	3	7161	28	ADCY2,PARD3,PLCB1
3.322e-02	-3.40	protein domain specific binding	molecular function	GO:0019904	651	5	18094	50	DTNA,TRPS1,MAP3K5,ARHGEF4,FYN
3.331e-02	-3.40	bone-femur-chondrosarcoma	COSMIC cancer mutations	bone-femur-chondrosarcoma	419	4	16828	49	HPSE2,LRP1B,ABCA1,ADCY2
3.350e-02	-3.40	postsynaptic cytosol	cellular component	GO:0099524	13	1	19108	50	PLCB1
3.355e-02	-3.39	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	33	NRG3,FYN
3.356e-02	-3.39	pituitary	COSMIC cancer mutations	pituitary	420	4	16828	49	PTPRZ1,RYR3,PARD3,NRCAM
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	MACF1,TRPS1
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	GPM6A,AHCYL1
3.363e-02	-3.39	TSC22D4 (TSC22 domain family member 4)	protein interactions	81628	112	2	19454	50	ABLIM1,CLU
3.363e-02	-3.39	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	2	19454	50	SOX5,TRPS1
3.373e-02	-3.39	positive regulation of protein localization to membrane	biological process	GO:1905477	105	2	18204	50	SORBS1,FYN
3.373e-02	-3.39	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	50	FYN,NRCAM
3.373e-02	-3.39	cellular response to alcohol	biological process	GO:0097306	105	2	18204	50	ADCY2,ABCA1
3.373e-02	-3.39	neural precursor cell proliferation	biological process	GO:0061351	105	2	18204	50	SOX5,RORA
3.385e-02	-3.39	protein-DNA complex	cellular component	GO:0032993	1454	8	19108	50	HIF3A,TSHZ2,TRPS1,PLCB1,NPAS3,RFX4,RORA,SOX5
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.394e-02	-3.38	CDK4 (cyclin dependent kinase 4)	protein interactions	1019	276	3	19454	50	BMPR1B,MAP3K5,SORBS1
3.395e-02	-3.38	active transmembrane transporter activity	molecular function	GO:0022804	444	4	18094	50	ATP1A2,ABCA1,SLC1A2,SLC7A11
3.418e-02	-3.38	MED28 (mediator complex subunit 28)	protein interactions	80306	113	2	19454	50	FYN,NEBL
3.431e-02	-3.37	eye-uveal_tract-malignant_melanoma-mixed	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-mixed	100	2	16828	49	ADCY2,ARHGEF4
3.432e-02	-3.37	oogenesis	biological process	GO:0048477	106	2	18204	50	FMN2,BMPR1B
3.435e-02	-3.37	LIM	smart domains	SM00132	71	2	9717	40	ABLIM1,NEBL
3.440e-02	-3.37	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_II	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_II	12	1	16828	49	TSHZ2
3.444e-02	-3.37	apical part of cell	cellular component	GO:0045177	471	4	19108	50	AHCYL1,PARD3,SLC7A11,PARD3B
3.452e-02	-3.37	AA_permease_2	pfam domains	PF13520	13	1	17795	48	SLC7A11
3.452e-02	-3.37	Ldl_recept_b	pfam domains	PF00058	13	1	17795	48	LRP1B
3.454e-02	-3.37	AA/rel_permease1	interpro domains	IPR002293	13	1	18521	50	SLC7A11
3.457e-02	-3.36	TJP2 (tight junction protein 2)	protein interactions	9414	278	3	19454	50	NEBL,SORBS1,PARD3
3.462e-02	-3.36	Pimethixene H1-Antihistamine Action	SMPDB pathways	SMP0062886	8	1	1369	6	PLCB1
3.462e-02	-3.36	Buclizine H1-Antihistamine Action	SMPDB pathways	SMP0058964	8	1	1369	6	PLCB1
3.462e-02	-3.36	Phenbenzamine H1-Antihistamine Action	SMPDB pathways	SMP0059702	8	1	1369	6	PLCB1
3.462e-02	-3.36	Dimetindene H1-Antihistamine Action	SMPDB pathways	SMP0057582	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mequitazine H1-Antihistamine Action	SMPDB pathways	SMP0059720	8	1	1369	6	PLCB1
3.462e-02	-3.36	Phenyltoloxamine H1-Antihistamine Action	SMPDB pathways	SMP0058916	8	1	1369	6	PLCB1
3.462e-02	-3.36	Flunarizine H1-Antihistamine Action	SMPDB pathways	SMP0061047	8	1	1369	6	PLCB1
3.462e-02	-3.36	Homochlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0062795	8	1	1369	6	PLCB1
3.462e-02	-3.36	Rupatadine H1-Antihistamine Action	SMPDB pathways	SMP0060235	8	1	1369	6	PLCB1
3.462e-02	-3.36	Astemizole H1-Antihistamine Action	SMPDB pathways	SMP0059897	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chloropyramine H1-Antihistamine Action	SMPDB pathways	SMP0057585	8	1	1369	6	PLCB1
3.462e-02	-3.36	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	6	ADCY2
3.462e-02	-3.36	Carbinoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058797	8	1	1369	6	PLCB1
3.462e-02	-3.36	Pyrrobutamine H1-Antihistamine Action	SMPDB pathways	SMP0062887	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chlorphenamine H1-Antihistamine Action	SMPDB pathways	SMP0056661	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cinnarizine H1-Antihistamine Action	SMPDB pathways	SMP0059110	8	1	1369	6	PLCB1
3.462e-02	-3.36	Latrepirdine H1-Antihistamine Action	SMPDB pathways	SMP0062623	8	1	1369	6	PLCB1
3.462e-02	-3.36	Histamine H1 Receptor Activation	SMPDB pathways	SMP0063452	8	1	1369	6	PLCB1
3.462e-02	-3.36	Dexbrompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057580	8	1	1369	6	PLCB1
3.462e-02	-3.36	Antazoline H1-Antihistamine Action	SMPDB pathways	SMP0057584	8	1	1369	6	PLCB1
3.462e-02	-3.36	Levocetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059114	8	1	1369	6	PLCB1
3.462e-02	-3.36	Alcaftadine H1-Antihistamine Action	SMPDB pathways	SMP0062881	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mizolastine H1-Antihistamine Action	SMPDB pathways	SMP0060230	8	1	1369	6	PLCB1
3.462e-02	-3.36	Desloratadine H1-Antihistamine Action	SMPDB pathways	SMP0060201	8	1	1369	6	PLCB1
3.462e-02	-3.36	Promethazine H1-Antihistamine Action	SMPDB pathways	SMP0059211	8	1	1369	6	PLCB1
3.462e-02	-3.36	Terfenadine H1-Antihistamine Action	SMPDB pathways	SMP0060208	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bromodiphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058813	8	1	1369	6	PLCB1
3.462e-02	-3.36	Ketotifen H1-Antihistamine Action	SMPDB pathways	SMP0059868	8	1	1369	6	PLCB1
3.462e-02	-3.36	Oxomemazine H1-Antihistamine Action	SMPDB pathways	SMP0059738	8	1	1369	6	PLCB1
3.462e-02	-3.36	Quifenadine H1-Antihistamine Action	SMPDB pathways	SMP0060743	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mebhydrolin H1-Antihistamine Action	SMPDB pathways	SMP0061052	8	1	1369	6	PLCB1
3.462e-02	-3.36	Ebastine H1-Antihistamine Action	SMPDB pathways	SMP0060204	8	1	1369	6	PLCB1
3.462e-02	-3.36	Emedastine H1-Antihistamine Action	SMPDB pathways	SMP0061040	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chlorphenoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058903	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thonzylamine H1-Antihistamine Action	SMPDB pathways	SMP0058769	8	1	1369	6	PLCB1
3.462e-02	-3.36	Pheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056662	8	1	1369	6	PLCB1
3.462e-02	-3.36	Methdilazine H1-Antihistamine Action	SMPDB pathways	SMP0059730	8	1	1369	6	PLCB1
3.462e-02	-3.36	Temelastine H1-Antihistamine Action	SMPDB pathways	SMP0062880	8	1	1369	6	PLCB1
3.462e-02	-3.36	Quetiapine H1-Antihistamine Action	SMPDB pathways	SMP0062884	8	1	1369	6	PLCB1
3.462e-02	-3.36	Triprolidine H1-Antihistamine Action	SMPDB pathways	SMP0057581	8	1	1369	6	PLCB1
3.462e-02	-3.36	Orphenadrine H1-Antihistamine Action	SMPDB pathways	SMP0058808	8	1	1369	6	PLCB1
3.462e-02	-3.36	Alimemazine H1-Antihistamine Action	SMPDB pathways	SMP0059689	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bepotastine H1-Antihistamine Action	SMPDB pathways	SMP0060058	8	1	1369	6	PLCB1
3.462e-02	-3.36	Brompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057579	8	1	1369	6	PLCB1
3.462e-02	-3.36	Levocabastine H1-Antihistamine Action	SMPDB pathways	SMP0060224	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mirtazapine H1-Antihistamine Action	SMPDB pathways	SMP0062885	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058923	8	1	1369	6	PLCB1
3.462e-02	-3.36	Tripelennamine H1-Antihistamine Action	SMPDB pathways	SMP0057587	8	1	1369	6	PLCB1
3.462e-02	-3.36	Fenethazine H1-Antihistamine Action	SMPDB pathways	SMP0059707	8	1	1369	6	PLCB1
3.462e-02	-3.36	Talastine H1-Antihistamine Action	SMPDB pathways	SMP0057586	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bilastine H1-Antihistamine Action	SMPDB pathways	SMP0060170	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bamipine H1-Antihistamine Action	SMPDB pathways	SMP0062882	8	1	1369	6	PLCB1
3.462e-02	-3.36	Azatadine H1-Antihistamine Action	SMPDB pathways	SMP0059865	8	1	1369	6	PLCB1
3.462e-02	-3.36	Tolpropamine H1-Antihistamine Action	SMPDB pathways	SMP0062621	8	1	1369	6	PLCB1
3.462e-02	-3.36	Deptropine H1-Antihistamine Action	SMPDB pathways	SMP0062883	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058931	8	1	1369	6	PLCB1
3.462e-02	-3.36	Loratadine H1-Antihistamine Action	SMPDB pathways	SMP0060195	8	1	1369	6	PLCB1
3.462e-02	-3.36	Histapyrrodine H1-Antihistamine Action	SMPDB pathways	SMP0058732	8	1	1369	6	PLCB1
3.462e-02	-3.36	Azelastine H1-Antihistamine Action	SMPDB pathways	SMP0060741	8	1	1369	6	PLCB1
3.462e-02	-3.36	Doxepin H1-Antihistamine Action	SMPDB pathways	SMP0059872	8	1	1369	6	PLCB1
3.462e-02	-3.36	Hydroxyzine H1-Antihistamine Action	SMPDB pathways	SMP0058936	8	1	1369	6	PLCB1
3.462e-02	-3.36	Methapyrilene H1-Antihistamine Action	SMPDB pathways	SMP0058741	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059058	8	1	1369	6	PLCB1
3.462e-02	-3.36	Epinastine H1-Antihistamine Action	SMPDB pathways	SMP0061191	8	1	1369	6	PLCB1
3.462e-02	-3.36	Isothipendyl H1-Antihistamine Action	SMPDB pathways	SMP0059716	8	1	1369	6	PLCB1
3.462e-02	-3.36	Acrivastine H1-Antihistamine Action	SMPDB pathways	SMP0059881	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cyproheptadine H1-Antihistamine Action	SMPDB pathways	SMP0059694	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thenalidine H1-Antihistamine Action	SMPDB pathways	SMP0062894	8	1	1369	6	PLCB1
3.462e-02	-3.36	Propiomazine H1-Antihistamine Action	SMPDB pathways	SMP0062625	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thiazinamium H1-Antihistamine Action	SMPDB pathways	SMP0060742	8	1	1369	6	PLCB1
3.462e-02	-3.36	Embramine H1-Antihistamine Action	SMPDB pathways	SMP0062622	8	1	1369	6	PLCB1
3.462e-02	-3.36	Clemastine H1-Antihistamine Action	SMPDB pathways	SMP0058891	8	1	1369	6	PLCB1
3.462e-02	-3.36	Clocinizine H1-Antihistamine Action	SMPDB pathways	SMP0062788	8	1	1369	6	PLCB1
3.462e-02	-3.36	Phenindamine H1-Antihistamine Action	SMPDB pathways	SMP0061190	8	1	1369	6	PLCB1
3.462e-02	-3.36	Dexchlorpheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056811	8	1	1369	6	PLCB1
3.462e-02	-3.36	Meclizine H1-Antihistamine Action	SMPDB pathways	SMP0058956	8	1	1369	6	PLCB1
3.462e-02	-3.36	Hydroxyethylpromethazine H1-Antihistamine Action	SMPDB pathways	SMP0059710	8	1	1369	6	PLCB1
3.462e-02	-3.36	Olopatadine H1-Antihistamine Action	SMPDB pathways	SMP0060740	8	1	1369	6	PLCB1
3.462e-02	-3.36	Diphenylpyraline H1-Antihistamine Action	SMPDB pathways	SMP0058908	8	1	1369	6	PLCB1
3.462e-02	-3.36	Betahistine H1-Antihistamine Action	SMPDB pathways	SMP0060744	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thenyldiamine H1-Antihistamine Action	SMPDB pathways	SMP0062624	8	1	1369	6	PLCB1
3.462e-02	-3.36	Fexofenadine H1-Antihistamine Action	SMPDB pathways	SMP0060218	8	1	1369	6	PLCB1
3.462e-02	-3.36	Oxatomide H1-Antihistamine Action	SMPDB pathways	SMP0059044	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mepyramine H1-Antihistamine Action	SMPDB pathways	SMP0057583	8	1	1369	6	PLCB1
3.462e-02	-3.36	Tritoqualine H1-Antihistamine Action	SMPDB pathways	SMP0062895	8	1	1369	6	PLCB1
3.462e-02	-3.36	Diphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058785	8	1	1369	6	PLCB1
3.462e-02	-3.36	Lysophosphatidic Acid LPA3 Signalling	SMPDB pathways	SMP0063755	8	1	1369	6	PLCB1
3.462e-02	-3.36	Doxylamine H1-Antihistamine Action	SMPDB pathways	SMP0058803	8	1	1369	6	PLCB1
3.466e-02	-3.36	Heparan sulfate degradation	KEGG pathways	hsa_M00078	9	1	7161	28	HPSE2
3.466e-02	-3.36	Heparan sulfate degradation	KEGG pathways	M00078	9	1	7161	28	HPSE2
3.474e-02	-3.36	TNFSF13B (TNF superfamily member 13b)	protein interactions	10673	114	2	19454	50	MAP3K5,CLU
3.474e-02	-3.36	PTP4A2 (protein tyrosine phosphatase 4A2)	protein interactions	8073	114	2	19454	50	FMN2,AHCYL1
3.493e-02	-3.35	Ion_trans	pfam domains	PF00520	109	2	17795	48	RYR3,TRPM3
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	TRPM3,RYR3
3.514e-02	-3.35	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	50	FYN
3.514e-02	-3.35	membrane disassembly	biological process	GO:0030397	13	1	18204	50	PRKCA
3.514e-02	-3.35	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	50	RORA
3.514e-02	-3.35	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	50	RORA
3.514e-02	-3.35	regulation of cellular amino acid metabolic process	biological process	GO:0006521	13	1	18204	50	SLC7A11
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	phospholipid efflux	biological process	GO:0033700	13	1	18204	50	ABCA1
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	1	18204	50	CLU
3.514e-02	-3.35	ectodermal placode development	biological process	GO:0071696	13	1	18204	50	NRG3
3.518e-02	-3.35	response to alcohol	biological process	GO:0097305	262	3	18204	50	ADCY2,ABCA1,FYN
3.523e-02	-3.35	SPOP (speckle type BTB/POZ protein)	protein interactions	8405	483	4	19454	50	MSI2,TSHZ2,SLC7A11,DTNA
3.527e-02	-3.34	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	24	AQP4,RORA,NTRK2
3.530e-02	-3.34	DTNA (dystrobrevin alpha)	protein interactions	1837	115	2	19454	50	PARD3,NTRK2
3.530e-02	-3.34	CDH2 (cadherin 2)	protein interactions	1000	115	2	19454	50	CTNND2,PARD3
3.530e-02	-3.34	GNS (glucosamine (N-acetyl)-6-sulfatase)	protein interactions	2799	115	2	19454	50	PRKCA,AHCYL1
3.530e-02	-3.34	beta-catenin binding	molecular function	GO:0008013	107	2	18094	50	CTNND2,RORA
3.535e-02	-3.34	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	50	BMPR1B
3.535e-02	-3.34	high-density lipoprotein particle binding	molecular function	GO:0008035	13	1	18094	50	ABCA1
3.535e-02	-3.34	potassium ion binding	molecular function	GO:0030955	13	1	18094	50	ATP1A2
3.539e-02	-3.34	HRAS (HRas proto-oncogene, GTPase)	protein interactions	3265	712	5	19454	50	PLCB1,MAPK10,SLC7A11,FYN,PARD3
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	FBXL7 (F-box and leucine rich repeat protein 7)	protein interactions	23194	14	1	19454	50	AHCYL1
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	LRP1B
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	ZNF628 (zinc finger protein 628)	protein interactions	89887	14	1	19454	50	EFEMP1
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	PRKCA
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	TAS2R7 (taste 2 receptor member 7)	protein interactions	50837	14	1	19454	50	PRKCA
3.540e-02	-3.34	C9 (complement C9)	protein interactions	735	14	1	19454	50	CLU
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.548e-02	-3.34	EGF_3	prosite domains	PS50026	196	3	12186	45	NRG3,EFEMP1,LRP1B
3.551e-02	-3.34	Thromboxane A2 receptor signaling	Pathway Interaction DB	txa2pathway	45	2	2226	15	FYN,PRKCA
3.552e-02	-3.34	cellular metabolic process	biological process	GO:0044237	5975	23	18204	50	EFEMP1,CLU,ABCA1,SLC1A2,KALRN,SOX5,NTRK2,CNTN1,AHCYL1,PRKCA,ADCY2,FYN,PTPRZ1,HIF3A,SLC7A11,DCLK2,BMPR1B,MAPK10,RORA,ATP1A2,PLCB1,GLIS3,MAP3K5
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.581e-02	-3.33	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	3	16828	49	MACF1,PTPRZ1,GLIS3
3.586e-02	-3.33	FCGRT (Fc gamma receptor and transporter)	protein interactions	2217	116	2	19454	50	CNTN1,CLU
3.589e-02	-3.33	plasma membrane raft	cellular component	GO:0044853	114	2	19108	50	SORBS1,ATP1A2
3.591e-02	-3.33	phosphatidylinositol bisphosphate binding	molecular function	GO:1902936	108	2	18094	50	PLCB1,PARD3
3.593e-02	-3.33	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	6	16828	49	GLIS3,HIF3A,FMN2,MAP3K5,EYA2,PLCB1
3.603e-02	-3.32	chromaffin granule	cellular component	GO:0042583	14	1	19108	50	CLU
3.612e-02	-3.32	postsynapse organization	biological process	GO:0099173	109	2	18204	50	FYN,CTNND2
3.621e-02	-3.32	thyroid-other-neoplasm	COSMIC cancer mutations	thyroid-other-neoplasm	7637	29	16828	49	ADCY2,MAP3K5,EYA2,TRPS1,CLU,FMN2,FYN,PTPRZ1,ABLIM1,MACF1,TRPM3,CTNND2,ATP1A2,LRP1B,ABCA1,KALRN,PRKCA,LSAMP,RORA,NRCAM,CNTN1,HIF3A,SLC7A11,GLIS3,PLCB1,DCLK2,PARD3B,AHCYL1,NRG3
3.621e-02	-3.32	regulation of nervous system development	biological process	GO:0051960	456	4	18204	50	NTRK2,MACF1,PARD3,PTPRZ1
3.632e-02	-3.32	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	33	FYN,NRG3
3.633e-02	-3.32	MIP	prosite domains	PS00221	10	1	12186	45	AQP4
3.633e-02	-3.32	MIR	prosite domains	PS50919	10	1	12186	45	RYR3
3.634e-02	-3.31	tube development	biological process	GO:0035295	903	6	18204	50	NRCAM,PRKCA,NTRK2,RORA,SLC7A11,HIF3A
3.639e-02	-3.31	Signaling by the B Cell Receptor (BCR)	REACTOME pathways	R-HSA-983705	229	3	10285	33	NRG3,FYN,AHCYL1
3.646e-02	-3.31	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	5	16828	49	PTPRZ1,PLCB1,NEBL,FMN2,SORBS1
3.646e-02	-3.31	DCX	smart domains	SM00537	9	1	9717	40	DCLK2
3.647e-02	-3.31	HYOU1 (hypoxia up-regulated 1)	protein interactions	10525	284	3	19454	50	CLU,EFEMP1,PRKCA
3.647e-02	-3.31	LATS2 (large tumor suppressor kinase 2)	protein interactions	26524	284	3	19454	50	SORBS1,MAP3K5,PARD3
3.670e-02	-3.30	positive regulation of cell development	biological process	GO:0010720	458	4	18204	50	PTPRZ1,MACF1,NTRK2,PRKCA
3.678e-02	-3.30	HLH_DNA-bd_sf	interpro domains	IPR036638	112	2	18521	50	HIF3A,NPAS3
3.678e-02	-3.30	bHLH_dom	interpro domains	IPR011598	112	2	18521	50	NPAS3,HIF3A
3.686e-02	-3.30	Laminin	gene3d domains	2.10.25.10	226	3	14470	47	LRP1B,NRG3,EFEMP1
3.695e-02	-3.30	synaptic signaling	biological process	GO:0099536	459	4	18204	50	PLCB1,SLC1A2,NTRK2,DTNA
3.699e-02	-3.30	DNM1 (dynamin 1)	protein interactions	1759	118	2	19454	50	GPM6A,PRKCA
3.703e-02	-3.30	EPH-Ephrin signaling	REACTOME pathways	R-HSA-2682334	95	2	10285	33	KALRN,FYN
3.712e-02	-3.29	SERPINH1 (serpin family H member 1)	protein interactions	871	286	3	19454	50	ARHGEF4,AHCYL1,EFEMP1
3.712e-02	-3.29	GATA	pfam domains	PF00320	14	1	17795	48	TRPS1
3.712e-02	-3.29	MIP	pfam domains	PF00230	14	1	17795	48	AQP4
3.715e-02	-3.29	MIP	interpro domains	IPR000425	14	1	18521	50	AQP4
3.715e-02	-3.29	Aquaporin-like	interpro domains	IPR023271	14	1	18521	50	AQP4
3.715e-02	-3.29	LDLR_classB_rpt	interpro domains	IPR000033	14	1	18521	50	LRP1B
3.721e-02	-3.29	Human Thyroid Stimulating Hormone (TSH) signaling pathway	WikiPathways	WP2032	68	2	5310	24	PLCB1,ADCY2
3.744e-02	-3.29	protein localization	biological process	GO:0008104	1954	10	18204	50	DCLK2,PARD3B,ABCA1,FMN2,CLU,MACF1,NRCAM,AHCYL1,PARD3,LRP1B
3.756e-02	-3.28	ANKRD26 (ankyrin repeat domain containing 26)	protein interactions	22852	119	2	19454	50	NTRK2,PARD3
3.756e-02	-3.28	ITGB4 (integrin subunit beta 4)	protein interactions	3691	119	2	19454	50	PRKCA,FYN
3.756e-02	-3.28	FADD (Fas associated via death domain)	protein interactions	8772	119	2	19454	50	ABCA1,SLC7A11
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.775e-02	-3.28	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	49	16828	49	HPSE2,ABLIM1,TRPM3,MACF1,TSHZ2,AQP4,NPAS3,TRPS1,BMPR1B,EYA2,EFEMP1,MAP3K5,PARD3,RYR3,AHCYL1,GPM6A,PLCB1,DCLK2,SOX5,PARD3B,PITPNC1,HIF3A,ATP1A2,LRP1B,KALRN,NTRK2,GPC5,ARHGEF4,CTNND2,RFX4,CLU,FMN2,FYN,PTPRZ1,DTNA,SORBS1,ADCY2,NRG3,MSI2,NEBL,RORA,NRCAM,CNTN1,SLC7A11,GLIS3,SLC1A2,ABCA1,LSAMP,PRKCA
3.779e-02	-3.28	oligopeptide transport	biological process	GO:0006857	14	1	18204	50	SLC7A11
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	50	AQP4
3.779e-02	-3.28	regulation of calcium ion import across plasma membrane	biological process	GO:1905664	14	1	18204	50	FYN
3.779e-02	-3.28	sodium ion export across plasma membrane	biological process	GO:0036376	14	1	18204	50	ATP1A2
3.779e-02	-3.28	response to redox state	biological process	GO:0051775	14	1	18204	50	SLC7A11
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	negative regulation of macrophage derived foam cell differentiation	biological process	GO:0010745	14	1	18204	50	ABCA1
3.779e-02	-3.28	mesodermal cell fate commitment	biological process	GO:0001710	14	1	18204	50	EYA2
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	cellular response to forskolin	biological process	GO:1904322	14	1	18204	50	ADCY2
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.779e-02	-3.28	regulation of sulfur metabolic process	biological process	GO:0042762	14	1	18204	50	SLC7A11
3.779e-02	-3.28	response to forskolin	biological process	GO:1904321	14	1	18204	50	ADCY2
3.785e-02	-3.27	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	33	GPC5
3.785e-02	-3.27	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	33	HIF3A
3.785e-02	-3.27	PECAM1 interactions	REACTOME pathways	R-HSA-210990	12	1	10285	33	FYN
3.785e-02	-3.27	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	33	GPC5
3.785e-02	-3.27	CD28 dependent Vav1 pathway	REACTOME pathways	R-HSA-389359	12	1	10285	33	FYN
3.788e-02	-3.27	ASCL4 (achaete-scute family bHLH transcription factor 4)	protein interactions	121549	15	1	19454	50	FYN
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CLU
3.788e-02	-3.27	GSTM1 (glutathione S-transferase mu 1)	protein interactions	2944	15	1	19454	50	MAP3K5
3.788e-02	-3.27	GRM7 (glutamate metabotropic receptor 7)	protein interactions	2917	15	1	19454	50	PRKCA
3.788e-02	-3.27	ABITRAM (actin binding transcription modulator)	protein interactions	54942	15	1	19454	50	FYN
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	ADRA1B (adrenoceptor alpha 1B)	protein interactions	147	15	1	19454	50	PRKCA
3.788e-02	-3.27	FN3K (fructosamine 3 kinase)	protein interactions	64122	15	1	19454	50	PRKCA
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive))	protein interactions	957	15	1	19454	50	PRKCA
3.788e-02	-3.27	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	50	PARD3
3.788e-02	-3.27	OLFM3 (olfactomedin 3)	protein interactions	118427	15	1	19454	50	LRP1B
3.788e-02	-3.27	GP6 (glycoprotein VI platelet)	protein interactions	51206	15	1	19454	50	FYN
3.788e-02	-3.27	DEFB123 (defensin beta 123)	protein interactions	245936	15	1	19454	50	LRP1B
3.788e-02	-3.27	OGG1 (8-oxoguanine DNA glycosylase)	protein interactions	4968	15	1	19454	50	PRKCA
3.801e-02	-3.27	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	50	MACF1
3.814e-02	-3.27	EYA2 (EYA transcriptional coactivator and phosphatase 2)	protein interactions	2139	120	2	19454	50	EYA2,TRPS1
3.821e-02	-3.26	chemical homeostasis	biological process	GO:0048878	914	6	18204	50	AQP4,ATP1A2,RORA,SLC7A11,ABCA1,RYR3
3.836e-02	-3.26	cellular macromolecule localization	biological process	GO:0070727	1962	10	18204	50	PARD3,LRP1B,AHCYL1,NRCAM,CLU,MACF1,PARD3B,DCLK2,ABCA1,FMN2
3.840e-02	-3.26	KIF14 (kinesin family member 14)	protein interactions	9928	1803	9	19454	50	ABLIM1,MSI2,FYN,PARD3,EYA2,NEBL,SOX5,MACF1,SORBS1
3.844e-02	-3.26	Methionine degradation	KEGG pathways	hsa_M00035	10	1	7161	28	AHCYL1
3.844e-02	-3.26	Methionine degradation	KEGG pathways	M00035	10	1	7161	28	AHCYL1
3.846e-02	-3.26	p75 NTR receptor-mediated signalling	REACTOME pathways	R-HSA-193704	97	2	10285	33	KALRN,ARHGEF4
3.855e-02	-3.26	axolemma	cellular component	GO:0030673	15	1	19108	50	SLC1A2
3.856e-02	-3.26	dendrite development	biological process	GO:0016358	113	2	18204	50	CTNND2,FYN
3.856e-02	-3.26	heart process	biological process	GO:0003015	113	2	18204	50	ATP1A2,FYN
3.856e-02	-3.26	negative regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001243	113	2	18204	50	FYN,CLU
3.856e-02	-3.26	metencephalon development	biological process	GO:0022037	113	2	18204	50	RORA,CNTN1
3.872e-02	-3.25	HASPIN (histone H3 associated protein kinase)	protein interactions	83903	121	2	19454	50	CNTN1,FYN
3.873e-02	-3.25	regulation of monoatomic ion transport	biological process	GO:0043269	466	4	18204	50	FYN,CNTN1,ATP1A2,AHCYL1
3.887e-02	-3.25	Lysophosphatidic Acid LPA2 Signalling	SMPDB pathways	SMP0063753	9	1	1369	6	PLCB1
3.887e-02	-3.25	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	6	ADCY2
3.887e-02	-3.25	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	6	ADCY2
3.887e-02	-3.25	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	6	ADCY2
3.887e-02	-3.25	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	6	ADCY2
3.887e-02	-3.25	Lysophosphatidic Acid LPA1 Signalling	SMPDB pathways	SMP0063746	9	1	1369	6	PLCB1
3.887e-02	-3.25	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	6	ADCY2
3.887e-02	-3.25	Nitric Oxide Signaling Pathway	SMPDB pathways	SMP0063777	9	1	1369	6	PRKCA
3.914e-02	-3.24	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	49	FMN2,PTPRZ1,CNTN1
3.915e-02	-3.24	tube morphogenesis	biological process	GO:0035239	685	5	18204	50	HIF3A,RORA,NTRK2,PRKCA,NRCAM
3.918e-02	-3.24	regulation of circadian rhythm	biological process	GO:0042752	114	2	18204	50	RORA,MAPK10
3.918e-02	-3.24	negative regulation of protein catabolic process	biological process	GO:0042177	114	2	18204	50	FMN2,FYN
3.923e-02	-3.24	Wnt Signaling Pathway	WikiPathways	WP428	70	2	5310	24	PRKCA,MAPK10
3.923e-02	-3.24	phosphatase activity	molecular function	GO:0016791	272	3	18094	50	ATP1A2,PTPRZ1,EYA2
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.954e-02	-3.23	PTEN (phosphatase and tensin homolog)	protein interactions	5728	734	5	19454	50	NRCAM,RYR3,EYA2,HPSE2,AHCYL1
3.959e-02	-3.23	calcium ion binding	molecular function	GO:0005509	683	5	18094	50	LRP1B,RYR3,PLCB1,MACF1,EFEMP1
3.972e-02	-3.23	FH2	pfam domains	PF02181	15	1	17795	48	FMN2
3.972e-02	-3.23	PI-PLC-Y	pfam domains	PF00387	15	1	17795	48	PLCB1
3.972e-02	-3.23	CRAL_TRIO_2	pfam domains	PF13716	15	1	17795	48	KALRN
3.972e-02	-3.23	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	48	ATP1A2
3.975e-02	-3.23	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	1	18521	50	PLCB1
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	PI-PLC_fam	interpro domains	IPR001192	15	1	18521	50	PLCB1
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.988e-02	-3.22	CCDC85C (coiled-coil domain containing 85C)	protein interactions	317762	123	2	19454	50	EYA2,PARD3
3.988e-02	-3.22	PTPRD (protein tyrosine phosphatase receptor type D)	protein interactions	5789	123	2	19454	50	ABLIM1,FYN
3.988e-02	-3.22	GNAQ (G protein subunit alpha q)	protein interactions	2776	123	2	19454	50	PLCB1,GPM6A
3.988e-02	-3.22	ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)	protein interactions	3708	123	2	19454	50	FYN,AHCYL1
3.989e-02	-3.22	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	45	TRPS1
3.989e-02	-3.22	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	45	NTRK2
3.999e-02	-3.22	TCR signaling in naive CD8+ T cells	Pathway Interaction DB	cd8tcrpathway	48	2	2226	15	FYN,PRKCA
4.020e-02	-3.21	MAPRE1 (microtubule associated protein RP/EB family member 1)	protein interactions	22919	504	4	19454	50	MACF1,FYN,PRKCA,ABLIM1
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	MACF1
4.035e-02	-3.21	GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3)	protein interactions	2562	16	1	19454	50	PRKCA
4.035e-02	-3.21	TAMALIN (trafficking regulator and scaffold protein tamalin)	protein interactions	160622	16	1	19454	50	FYN
4.035e-02	-3.21	WWC3 (WWC family member 3)	protein interactions	55841	16	1	19454	50	PRKCA
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	SLC6A9 (solute carrier family 6 member 9)	protein interactions	6536	16	1	19454	50	PRKCA
4.035e-02	-3.21	RHO (rhodopsin)	protein interactions	6010	16	1	19454	50	PRKCA
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKCA
4.035e-02	-3.21	NRGN (neurogranin)	protein interactions	4900	16	1	19454	50	PRKCA
4.042e-02	-3.21	Phenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000327	77	2	1369	6	PLCB1,ATP1A2
4.043e-02	-3.21	MIR	smart domains	SM00472	10	1	9717	40	RYR3
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	regulation of secondary metabolite biosynthetic process	biological process	GO:1900376	15	1	18204	50	SLC7A11
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	regulation of monoatomic anion transport	biological process	GO:0044070	15	1	18204	50	AHCYL1
4.043e-02	-3.21	regulation of melanin biosynthetic process	biological process	GO:0048021	15	1	18204	50	SLC7A11
4.043e-02	-3.21	p38MAPK cascade	biological process	GO:0038066	15	1	18204	50	MAP3K5
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	50	MACF1
4.043e-02	-3.21	response to laminar fluid shear stress	biological process	GO:0034616	15	1	18204	50	ABCA1
4.043e-02	-3.21	detection of mechanical stimulus involved in sensory perception of pain	biological process	GO:0050966	15	1	18204	50	FYN
4.043e-02	-3.21	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	50	NTRK2
4.043e-02	-3.21	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	50	SORBS1
4.043e-02	-3.21	pyramidal neuron differentiation	biological process	GO:0021859	15	1	18204	50	DCLK2
4.043e-02	-3.21	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	50	RORA
4.043e-02	-3.21	regulation of secondary metabolic process	biological process	GO:0043455	15	1	18204	50	SLC7A11
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	50	NTRK2
4.047e-02	-3.21	GLI4 (GLI family zinc finger 4)	protein interactions	2738	124	2	19454	50	EFEMP1,LRP1B
4.047e-02	-3.21	TNK2 (tyrosine kinase non receptor 2)	protein interactions	10188	124	2	19454	50	NTRK2,FYN
4.055e-02	-3.21	positive regulation of MAPK cascade	biological process	GO:0043410	473	4	18204	50	MAP3K5,NTRK2,PRKCA,PLCB1
4.067e-02	-3.20	filamin binding	molecular function	GO:0031005	15	1	18094	50	NEBL
4.067e-02	-3.20	low-density lipoprotein particle receptor activity	molecular function	GO:0005041	15	1	18094	50	LRP1B
4.067e-02	-3.20	tropomyosin binding	molecular function	GO:0005523	15	1	18094	50	NEBL
4.067e-02	-3.20	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	50	PITPNC1
4.069e-02	-3.20	LZTS2 (leucine zipper tumor suppressor 2)	protein interactions	84445	506	4	19454	50	NEBL,PARD3,EYA2,SORBS1
4.079e-02	-3.20	TJP1 (tight junction protein 1)	protein interactions	7082	297	3	19454	50	NEBL,DTNA,PARD3
4.080e-02	-3.20	actin filament organization	biological process	GO:0007015	278	3	18204	50	SORBS1,NEBL,FMN2
4.094e-02	-3.20	Passive transport by Aquaporins	REACTOME pathways	R-HSA-432047	13	1	10285	33	AQP4
4.094e-02	-3.20	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	33	AHCYL1
4.094e-02	-3.20	Platelet Adhesion to exposed collagen	REACTOME pathways	R-HSA-75892	13	1	10285	33	FYN
4.094e-02	-3.20	FCGR activation	REACTOME pathways	R-HSA-2029481	13	1	10285	33	FYN
4.094e-02	-3.20	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	33	NRG3
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	NTRK2,CNTN1,LSAMP,NRCAM
4.104e-02	-3.19	regulation of nucleobase-containing compound metabolic process	biological process	GO:0019219	4085	17	18204	50	NPAS3,HIF3A,FMN2,RORA,BMPR1B,PLCB1,MAP3K5,GLIS3,EFEMP1,CLU,SOX5,EYA2,AHCYL1,RFX4,TRPS1,PRKCA,TSHZ2
4.106e-02	-3.19	SOCS6 (suppressor of cytokine signaling 6)	protein interactions	9306	125	2	19454	50	BMPR1B,EFEMP1
4.106e-02	-3.19	UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats)	protein interactions	55075	125	2	19454	50	PARD3,AHCYL1
4.106e-02	-3.19	STXBP1 (syntaxin binding protein 1)	protein interactions	6812	125	2	19454	50	GPM6A,PRKCA
4.107e-02	-3.19	Focal adhesion	KEGG pathways	hsa04510	198	3	7161	28	FYN,PRKCA,MAPK10
4.107e-02	-3.19	cAMP signaling pathway	KEGG pathways	hsa04024	198	3	7161	28	ATP1A2,ADCY2,MAPK10
4.107e-02	-3.19	cAMP signaling pathway	KEGG pathways	ko04024	198	3	7161	28	MAPK10,ADCY2,ATP1A2
4.107e-02	-3.19	Focal adhesion	KEGG pathways	ko04510	198	3	7161	28	FYN,PRKCA,MAPK10
4.127e-02	-3.19	human chr20q13.2	chromosome location	human chr20q13.2	22	1	26134	50	TSHZ2
4.127e-02	-3.19	human chr3q13.31	chromosome location	human chr3q13.31	22	1	26134	50	LSAMP
4.139e-02	-3.18	L1CAM interactions	REACTOME pathways	R-HSA-373760	101	2	10285	33	NRCAM,CNTN1
4.139e-02	-3.18	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	2	10285	33	GPC5,PRKCA
4.146e-02	-3.18	upper_leg	COSMIC cancer mutations	upper_leg	880	6	16828	49	EYA2,GLIS3,HIF3A,FMN2,MAP3K5,PLCB1
4.159e-02	-3.18	circulatory system development	biological process	GO:0072359	933	6	18204	50	NTRK2,NRCAM,PRKCA,NEBL,HIF3A,RORA
4.166e-02	-3.18	CDK18 (cyclin dependent kinase 18)	protein interactions	5129	126	2	19454	50	TRPS1,EYA2
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	GPM6A,PITPNC1
4.182e-02	-3.17	PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha)	protein interactions	5573	300	3	19454	50	MAP3K5,FYN,PRKCA
4.199e-02	-3.17	heterocyclic compound binding	molecular function	GO:1901363	2263	11	18094	50	ADCY2,ATP1A2,ABCA1,MAP3K5,BMPR1B,KALRN,FYN,PRKCA,DCLK2,MAPK10,NTRK2
4.216e-02	-3.17	ARRB1 (arrestin beta 1)	protein interactions	408	301	3	19454	50	MAP3K5,LRP1B,MAPK10
4.219e-02	-3.17	HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)	protein interactions	9146	512	4	19454	50	EYA2,AHCYL1,ABCA1,NTRK2
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	EYA2,TRPS1
4.226e-02	-3.16	SCO2 (synthesis of cytochrome C oxidase 2)	protein interactions	9997	127	2	19454	50	DCLK2,EYA2
4.230e-02	-3.16	EGF-like_Ca-bd_dom	interpro domains	IPR001881	121	2	18521	50	LRP1B,EFEMP1
4.260e-02	-3.16	DNA-binding transcription factor activity	molecular function	GO:0003700	1441	8	18094	50	SOX5,HIF3A,RORA,GLIS3,RFX4,TSHZ2,NPAS3,TRPS1
4.268e-02	-3.15	TyrKc	smart domains	SM00219	80	2	9717	40	FYN,NTRK2
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	ZNF358 (zinc finger protein 358)	protein interactions	140467	17	1	19454	50	EFEMP1
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	PDE7A (phosphodiesterase 7A)	protein interactions	5150	17	1	19454	50	PRKCA
4.282e-02	-3.15	SCN1B (sodium voltage-gated channel beta subunit 1)	protein interactions	6324	17	1	19454	50	CNTN1
4.282e-02	-3.15	CYP3A4 (cytochrome P450 family 3 subfamily A member 4)	protein interactions	1576	17	1	19454	50	PRKCA
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	NFASC (neurofascin)	protein interactions	23114	17	1	19454	50	NRCAM
4.282e-02	-3.15	LIPT1 (lipoyltransferase 1)	protein interactions	51601	17	1	19454	50	PRKCA
4.285e-02	-3.15	PDZ	pfam domains	PF00595	122	2	17795	48	PARD3,PARD3B
4.286e-02	-3.15	BTK (Bruton tyrosine kinase)	protein interactions	695	128	2	19454	50	FYN,PRKCA
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.286e-02	-3.15	PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta)	protein interactions	5577	128	2	19454	50	GPM6A,PRKCA
4.286e-02	-3.15	TEAD2 (TEA domain transcription factor 2)	protein interactions	8463	128	2	19454	50	TRPS1,MAP3K5
4.302e-02	-3.15	bicellular tight junction	cellular component	GO:0005923	126	2	19108	50	PARD3,PARD3B
4.307e-02	-3.14	response to L-glutamate	biological process	GO:1902065	16	1	18204	50	FYN
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.307e-02	-3.14	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	50	ATP1A2
4.307e-02	-3.14	response to ether	biological process	GO:0045472	16	1	18204	50	PLCB1
4.307e-02	-3.14	positive regulation of mitochondrial membrane permeability involved in apoptotic process	biological process	GO:1902110	16	1	18204	50	EYA2
4.307e-02	-3.14	angiotensin-activated signaling pathway	biological process	GO:0038166	16	1	18204	50	AHCYL1
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	positive regulation of macrophage differentiation	biological process	GO:0045651	16	1	18204	50	PRKCA
4.307e-02	-3.14	S-adenosylmethionine metabolic process	biological process	GO:0046500	16	1	18204	50	AHCYL1
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.311e-02	-3.14	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	6	ADCY2
4.311e-02	-3.14	Lysophosphatidic Acid LPA5 Signalling	SMPDB pathways	SMP0063757	10	1	1369	6	PLCB1
4.311e-02	-3.14	Lysophosphatidic Acid LPA4 Signalling	SMPDB pathways	SMP0063756	10	1	1369	6	PLCB1
4.333e-02	-3.14	oxysterol binding	molecular function	GO:0008142	16	1	18094	50	RORA
4.333e-02	-3.14	diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004697	16	1	18094	50	PRKCA
4.333e-02	-3.14	misfolded protein binding	molecular function	GO:0051787	16	1	18094	50	CLU
4.333e-02	-3.14	floppase activity	molecular function	GO:0140328	16	1	18094	50	ABCA1
4.333e-02	-3.14	MAP kinase kinase activity	molecular function	GO:0004708	16	1	18094	50	MAPK10
4.333e-02	-3.14	MAP kinase activity	molecular function	GO:0004707	16	1	18094	50	MAPK10
4.333e-02	-3.14	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	50	ADCY2
4.333e-02	-3.14	water channel activity	molecular function	GO:0015250	16	1	18094	50	AQP4
4.333e-02	-3.14	lamin binding	molecular function	GO:0005521	16	1	18094	50	PLCB1
4.340e-02	-3.14	cellular response to chemical stress	biological process	GO:0062197	285	3	18204	50	SLC7A11,MAP3K5,FYN
4.344e-02	-3.14	MAPK	prosite domains	PS01351	12	1	12186	45	MAPK10
4.346e-02	-3.14	PLD1 (phospholipase D1)	protein interactions	5337	129	2	19454	50	PRKCA,AHCYL1
4.358e-02	-3.13	apical dendrite	cellular component	GO:0097440	17	1	19108	50	CLU
4.364e-02	-3.13	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	33	TRPM3,RYR3
4.368e-02	-3.13	EGF_2	prosite domains	PS01186	213	3	12186	45	LRP1B,NRG3,EFEMP1
4.402e-02	-3.12	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	33	NRG3
4.407e-02	-3.12	RSPH1 (radial spoke head component 1)	protein interactions	89765	130	2	19454	50	NRCAM,CLU
4.426e-02	-3.12	neuron projection terminus	cellular component	GO:0044306	128	2	19108	50	NTRK2,SLC1A2
4.448e-02	-3.11	cytoskeleton	cellular component	GO:0005856	2412	11	19108	50	FMN2,CLU,FYN,PRKCA,DTNA,ABLIM1,SORBS1,KALRN,MACF1,NEBL,PARD3
4.455e-02	-3.11	Glycerol uptake facilitator protein	gene3d domains	1.20.1080.10	14	1	14470	47	AQP4
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	EYA2,SOX5
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	EYA2,SOX5
4.468e-02	-3.11	membrane protein complex	cellular component	GO:0098796	1261	7	19108	50	SLC1A2,RYR3,PRKCA,SORBS1,ATP1A2,BMPR1B,MAP3K5
4.490e-02	-3.10	ZZ	pfam domains	PF00569	17	1	17795	48	DTNA
4.490e-02	-3.10	PI-PLC-X	pfam domains	PF00388	17	1	17795	48	PLCB1
4.490e-02	-3.10	Carb_anhydrase	pfam domains	PF00194	17	1	17795	48	PTPRZ1
4.492e-02	-3.10	Signal Transduction	REACTOME pathways	R-HSA-162582	2547	13	10285	33	NTRK2,KALRN,PRKCA,CNTN1,ADCY2,ARHGEF4,PARD3,PLCB1,FYN,AHCYL1,BMPR1B,GPC5,NRG3
4.493e-02	-3.10	PAC	interpro domains	IPR001610	17	1	18521	50	HIF3A
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY2
4.493e-02	-3.10	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	1	18521	50	PLCB1
4.493e-02	-3.10	ABC2_TM	interpro domains	IPR013525	17	1	18521	50	ABCA1
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.499e-02	-3.10	ITCH (itchy E3 ubiquitin protein ligase)	protein interactions	83737	309	3	19454	50	GLIS3,RORA,FYN
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	MSI2,NRG3,NEBL,RORA,NRCAM,GLIS3,CNTN1,SLC7A11,ABCA1,SLC1A2,LSAMP,PRKCA,ARHGEF4,GPC5,CTNND2,CLU,RFX4,FMN2,PTPRZ1,FYN,DTNA,SORBS1,ADCY2,AHCYL1,GPM6A,DCLK2,SOX5,PARD3B,PLCB1,PITPNC1,HIF3A,ATP1A2,KALRN,LRP1B,NTRK2,ABLIM1,HPSE2,TSHZ2,MACF1,TRPM3,TRPS1,AQP4,NPAS3,BMPR1B,EYA2,MAP3K5,PARD3,EFEMP1,RYR3
4.529e-02	-3.09	ZNF224 (zinc finger protein 224)	protein interactions	7767	18	1	19454	50	LRP1B
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	SOX30 (SRY-box transcription factor 30)	protein interactions	11063	18	1	19454	50	AHCYL1
4.529e-02	-3.09	CPNE9 (copine family member 9)	protein interactions	151835	18	1	19454	50	FYN
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	PARD3
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKCA
4.535e-02	-3.09	PRPF6 (pre-mRNA processing factor 6)	protein interactions	24148	310	3	19454	50	FYN,ARHGEF4,AHCYL1
4.551e-02	-3.09	Z disc	cellular component	GO:0030018	130	2	19108	50	RYR3,NEBL
4.567e-02	-3.09	inorganic ion transmembrane transport	biological process	GO:0098660	715	5	18204	50	ATP1A2,TRPM3,GPM6A,RYR3,PLCB1
4.570e-02	-3.09	positive regulation of cardiac muscle cell apoptotic process	biological process	GO:0010666	17	1	18204	50	MAP3K5
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	50	RORA
4.570e-02	-3.09	positive regulation of meiotic nuclear division	biological process	GO:0045836	17	1	18204	50	PLCB1
4.570e-02	-3.09	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	50	NTRK2
4.570e-02	-3.09	regulation of fertilization	biological process	GO:0080154	17	1	18204	50	PLCB1
4.570e-02	-3.09	regulation of receptor clustering	biological process	GO:1903909	17	1	18204	50	SLC7A11
4.570e-02	-3.09	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	50	ATP1A2
4.570e-02	-3.09	positive regulation of striated muscle cell apoptotic process	biological process	GO:0010663	17	1	18204	50	MAP3K5
4.570e-02	-3.09	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	50	SORBS1
4.570e-02	-3.09	phospholipid homeostasis	biological process	GO:0055091	17	1	18204	50	ABCA1
4.570e-02	-3.09	cGMP metabolic process	biological process	GO:0046068	17	1	18204	50	RORA
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	50	CLU
4.570e-02	-3.09	regulation of amyloid fibril formation	biological process	GO:1905906	17	1	18204	50	CLU
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	cellular response to reactive nitrogen species	biological process	GO:1902170	17	1	18204	50	MAP3K5
4.591e-02	-3.08	GABAergic synapse	KEGG pathways	ko04727	88	2	7161	28	ADCY2,PRKCA
4.591e-02	-3.08	GABAergic synapse	KEGG pathways	hsa04727	88	2	7161	28	ADCY2,PRKCA
4.591e-02	-3.08	PLD2 (phospholipase D2)	protein interactions	5338	133	2	19454	50	PRKCA,FYN
4.591e-02	-3.08	PLAUR (plasminogen activator, urokinase receptor)	protein interactions	5329	133	2	19454	50	LRP1B,FYN
4.591e-02	-3.08	MAGEA3 (MAGE family member A3)	protein interactions	4102	133	2	19454	50	CNTN1,EFEMP1
4.593e-02	-3.08	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	2	10285	33	SLC7A11,SLC1A2
4.597e-02	-3.08	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	50	PTPRZ1
4.597e-02	-3.08	apolipoprotein binding	molecular function	GO:0034185	17	1	18094	50	ABCA1
4.597e-02	-3.08	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	50	PTPRZ1
4.597e-02	-3.08	phospholipase activator activity	molecular function	GO:0016004	17	1	18094	50	FYN
4.614e-02	-3.08	tight junction	cellular component	GO:0070160	131	2	19108	50	PARD3B,PARD3
4.626e-02	-3.07	cerebral cortex development	biological process	GO:0021987	125	2	18204	50	NTRK2,PLCB1
4.626e-02	-3.07	actomyosin structure organization	biological process	GO:0031032	125	2	18204	50	SORBS1,NEBL
4.626e-02	-3.07	cellular component assembly involved in morphogenesis	biological process	GO:0010927	125	2	18204	50	CNTN1,NEBL
4.626e-02	-3.07	cellular anatomical entity morphogenesis	biological process	GO:0032989	125	2	18204	50	CNTN1,NEBL
4.631e-02	-3.07	cellular response to growth factor stimulus	biological process	GO:0071363	494	4	18204	50	NTRK2,SOX5,FYN,BMPR1B
4.642e-02	-3.07	extracellular region	cellular component	GO:0005576	4350	17	19108	50	AHCYL1,AQP4,NRG3,GPC5,LSAMP,NRCAM,KALRN,NEBL,ATP1A2,CLU,PRKCA,CNTN1,PTPRZ1,HPSE2,EFEMP1,PLCB1,GPM6A
4.653e-02	-3.07	EGFR (epidermal growth factor receptor)	protein interactions	1956	3105	13	19454	50	ABLIM1,TRPM3,TRPS1,SORBS1,DTNA,CLU,NTRK2,ABCA1,PARD3,CTNND2,SLC7A11,PRKCA,AHCYL1
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	CNTN1,GPM6A
4.662e-02	-3.07	ENO1 (enolase 1)	protein interactions	2023	529	4	19454	50	GLIS3,EFEMP1,DCLK2,FYN
4.674e-02	-3.06	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	5	19454	50	NTRK2,MSI2,CLU,SLC1A2,FYN
4.677e-02	-3.06	human chr20p12.3	chromosome location	human chr20p12.3	25	1	26134	50	PLCB1
4.677e-02	-3.06	human chr7q31.1	chromosome location	human chr7q31.1	25	1	26134	50	NRCAM
4.680e-02	-3.06	HSF2BP (heat shock transcription factor 2 binding protein)	protein interactions	11077	314	3	19454	50	MAP3K5,ABLIM1,ARHGEF4
4.693e-02	-3.06	limbic system development	biological process	GO:0021761	126	2	18204	50	DCLK2,ATP1A2
4.698e-02	-3.06	LDLRB	prosite domains	PS51120	13	1	12186	45	LRP1B
4.704e-02	-3.06	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	45	FYN,NTRK2
4.709e-02	-3.06	Depolymerisation of the Nuclear Lamina	REACTOME pathways	R-HSA-4419969	15	1	10285	33	PRKCA
4.709e-02	-3.06	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	33	ADCY2
4.709e-02	-3.06	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	33	ADCY2
4.709e-02	-3.06	WNT5A-dependent internalization of FZD4	REACTOME pathways	R-HSA-5099900	15	1	10285	33	PRKCA
4.709e-02	-3.06	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	33	NRG3
4.709e-02	-3.06	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME pathways	R-HSA-399955	15	1	10285	33	FYN
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	ABLIM1,TRPS1
4.716e-02	-3.05	BMP4 (bone morphogenetic protein 4)	protein interactions	652	135	2	19454	50	CLU,BMPR1B
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	NEBL,MSI2,NRG3,PRKCA,LSAMP,SLC1A2,ABCA1,CNTN1,SLC7A11,GLIS3,RORA,NRCAM,FYN,PTPRZ1,CLU,RFX4,FMN2,CTNND2,GPC5,ARHGEF4,ADCY2,SORBS1,DTNA,PITPNC1,PLCB1,DCLK2,SOX5,PARD3B,GPM6A,AHCYL1,NTRK2,LRP1B,KALRN,ATP1A2,HIF3A,BMPR1B,AQP4,NPAS3,TRPS1,MACF1,TRPM3,TSHZ2,HPSE2,ABLIM1,RYR3,EFEMP1,MAP3K5,PARD3,EYA2
4.734e-02	-3.05	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	6	RORA
4.746e-02	-3.05	regulation of anatomical structure size	biological process	GO:0090066	498	4	18204	50	AQP4,ATP1A2,MACF1,NRCAM
4.746e-02	-3.05	Growth_fac_rcpt_cys_sf	interpro domains	IPR009030	129	2	18521	50	EFEMP1,LRP1B
4.748e-02	-3.05	Cation_ATPase_N	pfam domains	PF00690	18	1	17795	48	ATP1A2
4.748e-02	-3.05	Guanylate_cyc	pfam domains	PF00211	18	1	17795	48	ADCY2
4.752e-02	-3.05	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	1	18521	50	ATP1A2
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY2
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY2
4.757e-02	-3.05	binding	molecular function	GO:0005488	16422	49	18094	50	ATP1A2,HPSE2,SLC1A2,KALRN,MAP3K5,MSI2,PARD3B,DTNA,BMPR1B,MACF1,EFEMP1,PTPRZ1,MAPK10,GPC5,AHCYL1,PLCB1,ADCY2,ABLIM1,NEBL,PARD3,RYR3,LRP1B,PRKCA,LSAMP,DCLK2,NPAS3,NRG3,TRPS1,AQP4,SOX5,RFX4,FMN2,RORA,FYN,SORBS1,ABCA1,CTNND2,SLC7A11,ARHGEF4,NRCAM,EYA2,GLIS3,TSHZ2,CNTN1,HIF3A,PITPNC1,NTRK2,GPM6A,CLU
4.760e-02	-3.05	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	50	PARD3,PRKCA
4.764e-02	-3.04	positive regulation of nervous system development	biological process	GO:0051962	296	3	18204	50	NTRK2,PTPRZ1,MACF1
4.765e-02	-3.04	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	47	FMN2
4.768e-02	-3.04	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	5	16828	49	NRG3,LRP1B,PARD3B,PARD3,MACF1
4.768e-02	-3.04	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	5	16828	49	NRG3,LRP1B,PARD3B,PARD3,MACF1
4.772e-02	-3.04	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	49	FMN2,CTNND2
4.774e-02	-3.04	GRAP (GRB2 related adaptor protein)	protein interactions	10750	19	1	19454	50	FYN
4.774e-02	-3.04	RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)	protein interactions	6236	19	1	19454	50	PRKCA
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	SIT1 (signaling threshold regulating transmembrane adaptor 1)	protein interactions	27240	19	1	19454	50	FYN
4.774e-02	-3.04	Mtx1 (metaxin 1)	protein interactions	17827	19	1	19454	50	FYN
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic subunit 3G)	protein interactions	60489	19	1	19454	50	MAP3K5
4.774e-02	-3.04	RIMS2 (regulating synaptic membrane exocytosis 2)	protein interactions	9699	19	1	19454	50	ABCA1
4.774e-02	-3.04	EGFL6 (EGF like domain multiple 6)	protein interactions	25975	19	1	19454	50	LRP1B
4.774e-02	-3.04	Trp53 (transformation related protein 53)	protein interactions	22059	19	1	19454	50	MAPK10
4.774e-02	-3.04	TRPV6 (transient receptor potential cation channel subfamily V member 6)	protein interactions	55503	19	1	19454	50	PRKCA
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	ZNF791 (zinc finger protein 791)	protein interactions	163049	19	1	19454	50	EFEMP1
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	PLCB2 (phospholipase C beta 2)	protein interactions	5330	19	1	19454	50	PLCB1
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	JSRP1 (junctional sarcoplasmic reticulum protein 1)	protein interactions	126306	19	1	19454	50	PRKCA
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	FAM3A (FAM3 metabolism regulating signaling molecule A)	protein interactions	60343	19	1	19454	50	EYA2
4.774e-02	-3.04	ZNF627 (zinc finger protein 627)	protein interactions	199692	19	1	19454	50	EFEMP1
4.794e-02	-3.04	catalytic activity, acting on a protein	molecular function	GO:0140096	2312	11	18094	50	EYA2,NTRK2,MAPK10,PTPRZ1,FYN,EFEMP1,KALRN,DCLK2,PRKCA,BMPR1B,MAP3K5
4.798e-02	-3.04	cell activation	biological process	GO:0001775	725	5	18204	50	SLC7A11,CLU,RORA,FYN,PLCB1
4.804e-02	-3.04	muscle system process	biological process	GO:0003012	297	3	18204	50	RYR3,ATP1A2,DTNA
4.804e-02	-3.04	carboxylic acid transport	biological process	GO:0046942	297	3	18204	50	SLC7A11,NTRK2,SLC1A2
4.822e-02	-3.03	cell population proliferation	biological process	GO:0008283	726	5	18204	50	SOX5,FYN,RORA,CLU,HPSE2
4.832e-02	-3.03	ZnF_GATA	smart domains	SM00401	12	1	9717	40	TRPS1
4.832e-02	-3.03	myelin maintenance	biological process	GO:0043217	18	1	18204	50	CLU
4.832e-02	-3.03	regulation of hydrogen peroxide metabolic process	biological process	GO:0010310	18	1	18204	50	FYN
4.832e-02	-3.03	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	50	NTRK2
4.832e-02	-3.03	regulation of endothelial cell development	biological process	GO:1901550	18	1	18204	50	PLCB1
4.832e-02	-3.03	regulation of acrosome reaction	biological process	GO:0060046	18	1	18204	50	PLCB1
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.832e-02	-3.03	mitochondrial outer membrane permeabilization involved in programmed cell death	biological process	GO:1902686	18	1	18204	50	EYA2
4.832e-02	-3.03	response to misfolded protein	biological process	GO:0051788	18	1	18204	50	CLU
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	positive regulation of myelination	biological process	GO:0031643	18	1	18204	50	PARD3
4.832e-02	-3.03	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	50	RORA
4.832e-02	-3.03	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	50	NEBL
4.832e-02	-3.03	regulation of establishment of endothelial barrier	biological process	GO:1903140	18	1	18204	50	PLCB1
4.838e-02	-3.03	TYRKINASE	prints domains	PR00109	98	2	5227	19	FYN,NTRK2
4.843e-02	-3.03	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	49	DTNA,TSHZ2
4.843e-02	-3.03	organic acid transport	biological process	GO:0015849	298	3	18204	50	SLC7A11,NTRK2,SLC1A2
4.852e-02	-3.03	cell cortex	cellular component	GO:0005938	313	3	19108	50	PARD3B,FMN2,PARD3
4.859e-02	-3.02	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	50	GPM6A
4.859e-02	-3.02	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	50	ATP1A2
4.859e-02	-3.02	cytosolic region	cellular component	GO:0099522	19	1	19108	50	PLCB1
4.859e-02	-3.02	human chr6q23.3	chromosome location	human chr6q23.3	26	1	26134	50	MAP3K5
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.859e-02	-3.02	human chr2p16.1	chromosome location	human chr2p16.1	26	1	26134	50	EFEMP1
4.861e-02	-3.02	lipoprotein particle receptor activity	molecular function	GO:0030228	18	1	18094	50	LRP1B
4.861e-02	-3.02	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	50	RYR3
4.861e-02	-3.02	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	50	NRG3
4.861e-02	-3.02	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	50	HPSE2
4.876e-02	-3.02	Morphine addiction	KEGG pathways	hsa05032	91	2	7161	28	PRKCA,ADCY2
4.876e-02	-3.02	Morphine addiction	KEGG pathways	ko05032	91	2	7161	28	ADCY2,PRKCA
4.884e-02	-3.02	Signaling by GPCR	REACTOME pathways	R-HSA-372790	1299	8	10285	33	NRG3,AHCYL1,FYN,PLCB1,PRKCA,KALRN,ARHGEF4,ADCY2
4.885e-02	-3.02	EGF_CA	prosite domains	PS01187	96	2	12186	45	LRP1B,EFEMP1
4.905e-02	-3.01	NFIB (nuclear factor I B)	protein interactions	4781	138	2	19454	50	TRPS1,SOX5
4.906e-02	-3.01	DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A)	protein interactions	1859	538	4	19454	50	EFEMP1,CLU,LRP1B,MAP3K5
4.921e-02	-3.01	cellular response to hormone stimulus	biological process	GO:0032870	504	4	18204	50	ATP1A2,SORBS1,AHCYL1,PLCB1
4.931e-02	-3.01	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	18	19454	50	PLCB1,PRKCA,AHCYL1,GPM6A,MACF1,PTPRZ1,KALRN,MSI2,CTNND2,PARD3,CLU,PITPNC1,NRCAM,DTNA,CNTN1,ATP1A2,LSAMP,DCLK2
4.952e-02	-3.01	channel activity	molecular function	GO:0015267	502	4	18094	50	TRPM3,RYR3,AQP4,GPM6A
4.962e-02	-3.00	thalamus	COSMIC cancer mutations	thalamus	284	3	16828	49	ABCA1,DTNA,TSHZ2
4.968e-02	-3.00	ARMC6 (armadillo repeat containing 6)	protein interactions	93436	139	2	19454	50	CLU,SLC7A11
4.972e-02	-3.00	Progesterone-mediated oocyte maturation	KEGG pathways	hsa04914	92	2	7161	28	ADCY2,MAPK10
4.972e-02	-3.00	Progesterone-mediated oocyte maturation	KEGG pathways	ko04914	92	2	7161	28	MAPK10,ADCY2
4.976e-02	-3.00	MINTRINSICP	prints domains	PR00783	14	1	5227	19	AQP4
4.982e-02	-3.00	passive transmembrane transporter activity	molecular function	GO:0022803	503	4	18094	50	AQP4,RYR3,GPM6A,TRPM3
4.987e-02	-3.00	bone-humerus-chondrosarcoma	COSMIC cancer mutations	bone-humerus-chondrosarcoma	123	2	16828	49	LRP1B,KALRN
4.999e-02	-3.00	regulation of biological quality	biological process	GO:0065008	2936	13	18204	50	NTRK2,ABCA1,MACF1,CLU,FYN,PRKCA,AQP4,GPM6A,EYA2,SLC7A11,NRCAM,PLCB1,ATP1A2