Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.168e-09	-20.57	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	17	19454	50	CLU,TRPM3,ATP1A2,CPE,MACF1,GPM6A,SLC1A3,ABLIM1,SPARCL1,SLC4A4,LSAMP,APOE,CAMK2G,NHSL1,MSI2,SORBS1,PTPRZ1
1.086e-08	-18.34	cell periphery	cellular component	GO:0071944	6020	35	19108	49	DTNA,NTRK2,CTNNA2,HIF3A,BMPR1B,GPM6A,TRPM3,PTPRZ1,FMN2,MACF1,SORBS1,APOE,ZNRF3,GPC5,SLC4A4,NRG3,TNIK,SLC1A2,ATP1A2,CST3,CTNND2,NRXN1,COL5A3,SLC1A3,CPE,SPARCL1,ATP13A4,NTM,PREX2,CLU,CDH20,FGFR3,RYR3,NKAIN3,LSAMP
5.110e-08	-16.79	mouth	COSMIC cancer mutations	mouth	9004	44	16828	49	CAMK2G,DTNA,FGFR3,ATP1A2,NRG3,HIF3A,CST3,MACF1,SLC1A3,ACSS1,NEBL,SOX5,RORA,SLC4A4,ABLIM1,PTPRZ1,FMN2,TNIK,CLU,LSAMP,CTNND2,APOE,NTRK2,ZBTB20,RANBP3L,TRPM3,PREX2,PITPNC1,NTM,SLC25A18,COL5A3,NPAS3,NRXN1,SORBS1,GPM6A,RYR3,PAMR1,SFXN5,ATP13A4,GPC5,ZNRF3,NHSL1,SLC1A2,CDH20
5.733e-08	-16.67	nervous system development	biological process	GO:0007399	2185	21	18204	49	CTNND2,NTM,NRXN1,SLC1A3,TNIK,NTRK2,RORA,PREX2,CLU,SLC1A2,GPM6A,CTNNA2,CAMK2G,LSAMP,MSI2,APOE,SOX5,PTPRZ1,NRG3,BMPR1B,ATP1A2
7.021e-08	-16.47	MAPT (microtubule associated protein tau)	protein interactions	4137	948	14	19454	50	NTM,CTNNA2,TNIK,CLU,NEBL,GPM6A,ATP1A2,ABLIM1,SLC1A3,CTNND2,APOE,LSAMP,SLC1A2,SORBS1
7.462e-08	-16.41	multicellular organism development	biological process	GO:0007275	3957	28	18204	49	FGFR3,RORA,PREX2,NRXN1,SLC1A3,NTM,RANBP3L,NTRK2,SOX5,APOE,MSI2,ATP1A2,BMPR1B,SLC1A2,CDH20,ZNRF3,HIF3A,CAMK2G,CTNND2,TNIK,PTPRZ1,NRG3,CLU,CTNNA2,GPM6A,NEBL,CPE,LSAMP
7.870e-08	-16.36	anatomical structure morphogenesis	biological process	GO:0009653	2225	21	18204	49	CDH20,GPM6A,CLU,CTNNA2,CPE,NEBL,HIF3A,PTPRZ1,SOX5,APOE,BMPR1B,NRG3,CTNND2,NRXN1,SLC1A3,TNIK,NTRK2,FGFR3,RORA,ABLIM1,PREX2
1.024e-07	-16.09	anatomical structure development	biological process	GO:0048856	5207	32	18204	49	COL5A3,LSAMP,CTNNA2,CLU,GPM6A,CPE,NEBL,NRG3,PTPRZ1,TNIK,CTNND2,ABLIM1,HIF3A,CAMK2G,CDH20,SLC1A2,FMN2,ZNRF3,BMPR1B,ATP1A2,SPARCL1,SOX5,MSI2,APOE,RANBP3L,NTRK2,NTM,NRXN1,SLC1A3,PREX2,FGFR3,RORA
1.086e-07	-16.04	lymph_node	COSMIC cancer mutations	lymph_node	1703	19	16828	49	RYR3,CTNND2,GPM6A,DTNA,FGFR3,ATP13A4,NTRK2,SFXN5,NRG3,LSAMP,TNIK,CAMK2G,SLC1A3,NEBL,SOX5,ACSS1,TRPM3,GPC5,RANBP3L
1.437e-07	-15.76	plasma membrane	cellular component	GO:0005886	5538	32	19108	49	LSAMP,FGFR3,RYR3,NKAIN3,NTM,PREX2,CDH20,CPE,ATP13A4,CTNND2,NRXN1,SLC1A3,CST3,ATP1A2,SLC4A4,NRG3,TNIK,SLC1A2,ZNRF3,GPC5,APOE,MACF1,SORBS1,FMN2,TRPM3,GPM6A,PTPRZ1,CTNNA2,HIF3A,BMPR1B,NTRK2,DTNA
1.498e-07	-15.71	system development	biological process	GO:0048731	3533	26	18204	49	NEBL,CPE,GPM6A,CLU,CTNNA2,LSAMP,PTPRZ1,NRG3,CTNND2,TNIK,SLC1A2,CAMK2G,HIF3A,APOE,MSI2,SOX5,ATP1A2,BMPR1B,SLC1A3,NRXN1,NTM,NTRK2,RANBP3L,RORA,FGFR3,PREX2
2.457e-07	-15.22	developmental process	biological process	GO:0032502	5716	33	18204	49	NEBL,CPE,GPM6A,CLU,CTNNA2,LSAMP,NHSL1,COL5A3,PTPRZ1,NRG3,CTNND2,TNIK,ABLIM1,FMN2,ZNRF3,SLC1A2,CDH20,CAMK2G,HIF3A,APOE,MSI2,SPARCL1,SOX5,ATP1A2,BMPR1B,NRXN1,SLC1A3,NTM,NTRK2,RANBP3L,RORA,FGFR3,PREX2
2.559e-07	-15.18	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	38	16828	49	LSAMP,CAMK2G,TNIK,CTNND2,FGFR3,DTNA,ATP1A2,ZBTB20,HIF3A,NRG3,MACF1,CST3,RANBP3L,TRPM3,PITPNC1,PREX2,NTM,NRXN1,SLC25A18,SOX5,NEBL,SORBS1,ACSS1,GPM6A,RYR3,SFXN5,ATP13A4,SLC4A4,PAMR1,RORA,ZNRF3,GPC5,ABLIM1,NHSL1,PTPRZ1,CDH20,SLC1A2,FMN2
3.322e-07	-14.92	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	43	16828	49	NHSL1,ZNRF3,GPC5,CDH20,SLC1A2,SORBS1,NRXN1,COL5A3,NPAS3,SLC25A18,NKAIN3,SFXN5,ATP13A4,SPARCL1,GPM6A,RYR3,PITPNC1,PREX2,NTM,TRPM3,MSI2,CLU,LSAMP,TNIK,NTRK2,ZBTB20,CTNND2,APOE,ABLIM1,PTPRZ1,FMN2,SOX5,NEBL,SLC1A3,SLC4A4,RORA,CPE,MACF1,BMPR1B,HIF3A,NRG3,FGFR3,DTNA
5.085e-07	-14.49	tibia	COSMIC cancer mutations	tibia	836	13	16828	49	PREX2,TRPM3,ABLIM1,RANBP3L,MACF1,CPE,NKAIN3,FGFR3,CTNND2,GPM6A,ACSS1,TNIK,LSAMP
6.096e-07	-14.31	nodular	COSMIC cancer mutations	nodular	1515	17	16828	49	SLC4A4,HIF3A,NTRK2,ATP13A4,SPARCL1,CPE,CTNND2,ATP1A2,FGFR3,NEBL,NPAS3,PREX2,CDH20,FMN2,PTPRZ1,ABLIM1,MACF1
6.811e-07	-14.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	15	16828	49	SLC1A2,PREX2,TNIK,CAMK2G,BMPR1B,LSAMP,NPAS3,COL5A3,SOX5,ATP1A2,FGFR3,RYR3,NRG3,NKAIN3,NTRK2
6.811e-07	-14.20	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	15	16828	49	NTRK2,NKAIN3,NRG3,RYR3,FGFR3,ATP1A2,SOX5,LSAMP,NPAS3,COL5A3,BMPR1B,TNIK,CAMK2G,PREX2,SLC1A2
9.146e-07	-13.90	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	27	16828	49	PREX2,NTM,LSAMP,BMPR1B,TNIK,CTNND2,HIF3A,ZBTB20,NTRK2,NRG3,GPC5,PTPRZ1,FMN2,SLC1A2,NRXN1,COL5A3,SLC1A3,SOX5,NEBL,RYR3,GPM6A,SLC4A4,NKAIN3,ATP13A4,CPE,RORA,PAMR1
9.146e-07	-13.90	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	27	16828	49	FMN2,SLC1A2,PTPRZ1,GPC5,RORA,PAMR1,CPE,ATP13A4,NKAIN3,SLC4A4,GPM6A,RYR3,NEBL,SOX5,SLC1A3,COL5A3,NRXN1,PREX2,NTM,NRG3,NTRK2,ZBTB20,HIF3A,CTNND2,TNIK,BMPR1B,LSAMP
1.130e-06	-13.69	brainstem	COSMIC cancer mutations	brainstem	3102	24	16828	49	SOX5,NPAS3,SLC1A3,SFXN5,ATP13A4,NKAIN3,CPE,RORA,RYR3,GPM6A,PTPRZ1,ZNRF3,GPC5,CDH20,FMN2,SLC1A2,LSAMP,TNIK,ZBTB20,NRG3,CTNND2,FGFR3,RANBP3L,PREX2
1.275e-06	-13.57	neurogenesis	biological process	GO:0022008	1334	15	18204	49	SOX5,PTPRZ1,APOE,BMPR1B,CLU,GPM6A,CTNNA2,RORA,PREX2,NRXN1,SLC1A3,CTNND2,NTM,TNIK,NTRK2
1.354e-06	-13.51	generation of neurons	biological process	GO:0048699	1158	14	18204	49	GPM6A,CTNNA2,PTPRZ1,SOX5,APOE,BMPR1B,CTNND2,NTM,SLC1A3,NRXN1,NTRK2,TNIK,RORA,PREX2
1.606e-06	-13.34	cell morphogenesis	biological process	GO:0000902	687	11	18204	49	PTPRZ1,BMPR1B,PREX2,CDH20,CTNND2,CLU,SLC1A3,GPM6A,CTNNA2,NRXN1,TNIK
1.623e-06	-13.33	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	8	19454	50	CTNNA2,TNIK,NEBL,MACF1,ABLIM1,NHSL1,DTNA,SORBS1
2.071e-06	-13.09	neuron development	biological process	GO:0048666	859	12	18204	49	NTM,CTNND2,SLC1A3,NRXN1,NTRK2,TNIK,PREX2,GPM6A,CTNNA2,APOE,PTPRZ1,BMPR1B
2.567e-06	-12.87	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	10	16828	49	SOX5,LSAMP,GPC5,SFXN5,NKAIN3,NRG3,CTNND2,GPM6A,RYR3,FMN2
2.644e-06	-12.84	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	21	16828	49	FMN2,CDH20,PREX2,GPC5,ZNRF3,PTPRZ1,RANBP3L,CTNND2,GPM6A,RYR3,RORA,NRG3,CPE,NKAIN3,SFXN5,ATP13A4,ZBTB20,SLC1A3,TNIK,LSAMP,SOX5
2.979e-06	-12.72	L-aspartate transmembrane transport	biological process	GO:0070778	11	3	18204	49	SLC1A2,SLC1A3,SLC25A18
3.759e-06	-12.49	neuron differentiation	biological process	GO:0030182	1081	13	18204	49	APOE,PTPRZ1,BMPR1B,GPM6A,CTNNA2,RORA,PREX2,NTM,CTNND2,NRXN1,SLC1A3,TNIK,NTRK2
4.679e-06	-12.27	cell junction	cellular component	GO:0030054	2224	18	19108	49	SLC1A2,TNIK,NRG3,FGFR3,APOE,CLU,CDH20,SORBS1,SPARCL1,SLC1A3,NRXN1,CTNND2,PTPRZ1,GPM6A,ATP1A2,CTNNA2,NTRK2,DTNA
4.871e-06	-12.23	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	27	16828	49	CDH20,FMN2,SLC1A2,GPC5,RYR3,GPM6A,ATP13A4,NKAIN3,SPARCL1,CPE,RORA,SLC1A3,SOX5,NEBL,ACSS1,PREX2,MACF1,RANBP3L,CTNND2,ATP1A2,DTNA,FGFR3,NTRK2,NRG3,LSAMP,CLU,TNIK
6.248e-06	-11.98	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	3	18094	48	SLC1A2,SLC1A3,SLC25A18
6.364e-06	-11.96	acidic amino acid transport	biological process	GO:0015800	45	4	18204	49	SLC25A18,NTRK2,SLC1A3,SLC1A2
7.063e-06	-11.86	multicellular organismal process	biological process	GO:0032501	6177	32	18204	49	CAMK2G,HIF3A,ZNRF3,CDH20,SLC1A2,BMPR1B,ATP1A2,MSI2,APOE,SOX5,NTRK2,RANBP3L,NTM,SLC1A3,NRXN1,RYR3,PREX2,RORA,FGFR3,LSAMP,CPE,NEBL,GPM6A,CLU,CTNNA2,NRG3,PTPRZ1,TNIK,SLC4A4,CTNND2,DTNA,ABLIM1
7.388e-06	-11.82	pharynx	COSMIC cancer mutations	pharynx	2696	21	16828	49	NRG3,SLC4A4,NTRK2,ATP13A4,SFXN5,ATP1A2,DTNA,FGFR3,RYR3,CTNND2,SORBS1,CLU,NPAS3,PREX2,PITPNC1,SLC1A2,FMN2,PTPRZ1,NHSL1,GPC5,MACF1
8.073e-06	-11.73	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	9	16828	49	GPC5,LSAMP,TRPM3,RYR3,GPM6A,CTNND2,NRG3,ATP13A4,SFXN5
9.320e-06	-11.58	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	14	16828	49	ATP13A4,NTRK2,NRG3,PAMR1,RYR3,CTNND2,GPM6A,FGFR3,NEBL,TNIK,NTM,FMN2,ABLIM1,MACF1
9.320e-06	-11.58	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	14	16828	49	NTRK2,ATP13A4,NRG3,PAMR1,RYR3,CTNND2,GPM6A,FGFR3,NEBL,TNIK,NTM,FMN2,ABLIM1,MACF1
9.417e-06	-11.57	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	11	16828	49	COL5A3,LSAMP,GPC5,SOX5,RYR3,ATP1A2,SLC1A2,NTRK2,NKAIN3,PREX2,NRG3
1.002e-05	-11.51	cerebellum	COSMIC cancer mutations	cerebellum	769	11	16828	49	ABLIM1,PTPRZ1,GPC5,NTRK2,CPE,NRG3,CTNND2,RYR3,NEBL,NRXN1,NPAS3
1.097e-05	-11.42	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	24	16828	49	NPAS3,SLC1A3,SLC4A4,PAMR1,CPE,RYR3,PTPRZ1,GPC5,ZNRF3,FMN2,MSI2,CLU,LSAMP,TNIK,BMPR1B,NTRK2,NRG3,CTNND2,DTNA,RANBP3L,MACF1,PREX2,PITPNC1,TRPM3
1.097e-05	-11.42	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	24	16828	49	PTPRZ1,ZNRF3,GPC5,FMN2,SLC1A3,NPAS3,CPE,PAMR1,SLC4A4,RYR3,RANBP3L,MACF1,PITPNC1,PREX2,TRPM3,MSI2,TNIK,BMPR1B,CLU,LSAMP,NRG3,NTRK2,DTNA,CTNND2
1.198e-05	-11.33	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	14	16828	49	CDH20,PREX2,MACF1,PTPRZ1,ABLIM1,CTNND2,ATP1A2,HIF3A,ATP13A4,NTRK2,SPARCL1,CPE,NPAS3,NEBL
1.272e-05	-11.27	synapse	cellular component	GO:0045202	1473	14	19108	49	DTNA,NTRK2,ATP1A2,PTPRZ1,GPM6A,SLC1A3,NRXN1,CTNND2,SPARCL1,APOE,CLU,SLC1A2,TNIK,NRG3
1.310e-05	-11.24	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	36	16828	49	FGFR3,CTNND2,NRG3,ZBTB20,NTRK2,TNIK,LSAMP,TRPM3,PITPNC1,PREX2,NTM,MACF1,RANBP3L,RYR3,GPM6A,CPE,PAMR1,RORA,SLC4A4,SFXN5,NKAIN3,ATP13A4,SLC1A3,NPAS3,COL5A3,NRXN1,ACSS1,SORBS1,NEBL,SOX5,FMN2,SLC1A2,GPC5,PTPRZ1,ABLIM1,NHSL1
1.332e-05	-11.23	scalp	COSMIC cancer mutations	scalp	2110	18	16828	49	PTPRZ1,MACF1,GPC5,PREX2,NTM,FMN2,SOX5,NEBL,SORBS1,COL5A3,LSAMP,NRXN1,CAMK2G,ATP13A4,SLC4A4,RORA,FGFR3,ATP1A2
1.390e-05	-11.18	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	3	18094	48	SLC1A2,SLC1A3,SLC25A18
1.413e-05	-11.17	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	18	16828	49	SOX5,BMPR1B,SLC1A3,NPAS3,LSAMP,CPE,NRG3,NTRK2,NKAIN3,ATP13A4,RYR3,CTNND2,GPM6A,NHSL1,GPC5,PREX2,SLC1A2,FMN2
1.413e-05	-11.17	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	18	16828	49	ATP13A4,NTRK2,NKAIN3,CPE,NRG3,RYR3,CTNND2,GPM6A,SOX5,LSAMP,NPAS3,BMPR1B,SLC1A3,PREX2,FMN2,SLC1A2,NHSL1,GPC5
1.509e-05	-11.10	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	10	16828	49	NPAS3,NRXN1,NEBL,ABLIM1,PTPRZ1,CTNND2,RYR3,NTRK2,NRG3,CPE
1.529e-05	-11.09	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	10	16828	49	PTPRZ1,NEBL,ABLIM1,NPAS3,NRXN1,NTRK2,CPE,NRG3,RYR3,CTNND2
1.702e-05	-10.98	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	15	16828	49	NKAIN3,NTRK2,RORA,NRG3,CTNND2,RYR3,SOX5,NEBL,ACSS1,LSAMP,COL5A3,SLC1A3,PREX2,FMN2,GPC5
1.702e-05	-10.98	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	15	16828	49	FMN2,PREX2,GPC5,CTNND2,RYR3,RORA,NRG3,NKAIN3,NTRK2,SLC1A3,LSAMP,COL5A3,ACSS1,NEBL,SOX5
1.766e-05	-10.94	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	3	19454	50	CST3,NRXN1,CTNND2
1.782e-05	-10.94	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	24	16828	49	ACSS1,SOX5,NEBL,CPE,SPARCL1,RORA,ATP13A4,NKAIN3,RYR3,GPM6A,GPC5,SLC1A2,FMN2,CDH20,TNIK,LSAMP,CLU,NRG3,ATP1A2,FGFR3,CTNND2,RANBP3L,MACF1,PREX2
2.023e-05	-10.81	aspartate transmembrane transport	biological process	GO:0015810	20	3	18204	49	SLC25A18,SLC1A2,SLC1A3
2.257e-05	-10.70	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	10	18094	48	SLC4A4,RYR3,ATP1A2,SLC1A2,SLC1A3,SFXN5,GPM6A,ATP13A4,SLC25A18,TRPM3
2.544e-05	-10.58	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	18	16828	49	COL5A3,LSAMP,SLC1A3,NEBL,SOX5,GPM6A,CTNND2,RYR3,FGFR3,NKAIN3,NTRK2,NRG3,GPC5,PTPRZ1,CDH20,FMN2,SLC1A2,PREX2
2.586e-05	-10.56	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	37	16828	49	RANBP3L,MACF1,PREX2,TRPM3,TNIK,CAMK2G,BMPR1B,CLU,LSAMP,NRG3,NTRK2,FGFR3,ATP1A2,CTNND2,APOE,NHSL1,ABLIM1,PTPRZ1,GPC5,SLC1A2,FMN2,CDH20,ACSS1,SOX5,NEBL,SLC1A3,SLC25A18,COL5A3,PAMR1,RORA,CPE,SFXN5,NKAIN3,ATP13A4,SLC4A4,GPM6A,RYR3
2.743e-05	-10.50	amino acid transport	biological process	GO:0006865	132	5	18204	49	SLC1A3,SLC1A2,SFXN5,SLC25A18,NTRK2
2.908e-05	-10.45	bone	COSMIC cancer mutations	bone	8157	38	16828	49	NKAIN3,SFXN5,ATP13A4,SLC4A4,PAMR1,RORA,CPE,SPARCL1,GPM6A,RYR3,NEBL,SOX5,SORBS1,ACSS1,NPAS3,NRXN1,COL5A3,SLC1A3,FMN2,ABLIM1,PTPRZ1,GPC5,NTRK2,HIF3A,ZBTB20,NRG3,CTNND2,DTNA,FGFR3,ATP1A2,LSAMP,TNIK,CAMK2G,PREX2,TRPM3,RANBP3L,MACF1,CST3
2.973e-05	-10.42	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	47	16828	49	PTPRZ1,ABLIM1,FMN2,SLC1A3,ACSS1,SOX5,NEBL,CPE,RORA,SLC4A4,MACF1,CAMK2G,BMPR1B,ATP1A2,FGFR3,DTNA,NRG3,HIF3A,GPC5,ZNRF3,NHSL1,SLC1A2,CDH20,SLC25A18,NRXN1,COL5A3,NPAS3,SORBS1,RYR3,GPM6A,SPARCL1,PAMR1,ATP13A4,NKAIN3,SFXN5,RANBP3L,TRPM3,NTM,PREX2,PITPNC1,TNIK,CLU,LSAMP,MSI2,CTNND2,ZBTB20,NTRK2
3.532e-05	-10.25	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	9	18094	48	ATP1A2,SLC1A2,SLC1A3,SLC4A4,RYR3,SLC25A18,ATP13A4,TRPM3,GPM6A
4.043e-05	-10.12	L-glutamate transmembrane transport	biological process	GO:0015813	25	3	18204	49	SLC25A18,SLC1A3,SLC1A2
4.148e-05	-10.09	cell development	biological process	GO:0048468	2236	17	18204	49	RORA,PREX2,CTNND2,NTM,NRXN1,SLC1A3,NTRK2,TNIK,MSI2,APOE,PTPRZ1,BMPR1B,FMN2,NEBL,GPM6A,CTNNA2,CLU
4.197e-05	-10.08	neuron projection morphogenesis	biological process	GO:0048812	486	8	18204	49	PREX2,BMPR1B,PTPRZ1,TNIK,NRXN1,CTNNA2,GPM6A,CTNND2
4.512e-05	-10.01	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	8	18204	49	CTNNA2,GPM6A,NRXN1,CTNND2,TNIK,PTPRZ1,PREX2,BMPR1B
4.562e-05	-10.00	C4-dicarboxylate transport	biological process	GO:0015740	26	3	18204	49	SLC1A3,SLC1A2,SLC25A18
4.581e-05	-9.99	monoatomic ion transmembrane transport	biological process	GO:0034220	804	10	18204	49	SLC25A18,ATP1A2,RYR3,ATP13A4,TRPM3,SFXN5,SLC4A4,SLC1A3,GPM6A,SLC1A2
4.847e-05	-9.93	cell projection morphogenesis	biological process	GO:0048858	496	8	18204	49	PREX2,BMPR1B,TNIK,GPM6A,NRXN1,CTNNA2,CTNND2,PTPRZ1
5.256e-05	-9.85	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	31	SLC1A3,SLC1A2
5.256e-05	-9.85	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	31	SLC1A3,SLC1A2
5.590e-05	-9.79	transporter activity	molecular function	GO:0005215	1211	12	18094	48	TRPM3,ATP13A4,SLC25A18,GPM6A,SFXN5,APOE,SLC1A3,SLC1A2,ATP1A2,RYR3,PITPNC1,SLC4A4
5.708e-05	-9.77	dicarboxylic acid transport	biological process	GO:0006835	78	4	18204	49	SLC1A2,SLC1A3,SLC25A18,NTRK2
6.099e-05	-9.70	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	3	18094	48	SLC25A18,SLC1A3,SLC1A2
6.375e-05	-9.66	negative regulation of amyloid-beta formation	biological process	GO:1902430	29	3	18204	49	APOE,CLU,NTRK2
6.535e-05	-9.64	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	20	16828	49	CTNND2,GPM6A,RYR3,NTRK2,SFXN5,ATP13A4,NKAIN3,HIF3A,NRG3,CPE,LSAMP,SLC1A3,NEBL,SOX5,TRPM3,FMN2,SLC1A2,PREX2,GPC5,ZNRF3
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A2,SLC1A3
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A2,SLC1A3
7.004e-05	-9.57	cell differentiation	biological process	GO:0030154	3645	22	18204	49	RORA,FGFR3,PREX2,NRXN1,SLC1A3,CTNND2,NTM,NTRK2,TNIK,RANBP3L,APOE,MSI2,PTPRZ1,SOX5,BMPR1B,NEBL,FMN2,CTNNA2,GPM6A,CLU,CAMK2G,NHSL1
7.061e-05	-9.56	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	49	SLC1A2,SLC1A3
7.061e-05	-9.56	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	2	18204	49	APOE,CLU
7.061e-05	-9.56	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	49	SLC1A2,SLC1A3
7.070e-05	-9.56	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	49	ATP1A2,SLC1A3,SLC1A2
7.070e-05	-9.56	L-glutamate import	biological process	GO:0051938	30	3	18204	49	SLC25A18,SLC1A2,SLC1A3
7.095e-05	-9.55	cellular developmental process	biological process	GO:0048869	3648	22	18204	49	GPM6A,CTNNA2,CLU,FMN2,NEBL,NHSL1,CAMK2G,PTPRZ1,SOX5,MSI2,APOE,BMPR1B,NTM,CTNND2,NRXN1,SLC1A3,RANBP3L,NTRK2,TNIK,FGFR3,RORA,PREX2
7.654e-05	-9.48	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	16	16828	49	FGFR3,GPM6A,RYR3,RORA,SLC4A4,ZBTB20,BMPR1B,TNIK,NPAS3,COL5A3,NRXN1,SOX5,NEBL,FMN2,ZNRF3,MACF1
7.700e-05	-9.47	cell body	cellular component	GO:0044297	556	8	19108	49	BMPR1B,ATP1A2,APOE,GPM6A,SLC1A3,SLC1A2,NRXN1,CTNND2
7.750e-05	-9.47	larynx	COSMIC cancer mutations	larynx	1948	16	16828	49	FGFR3,GPM6A,RYR3,RORA,ZBTB20,SLC4A4,TNIK,BMPR1B,NPAS3,COL5A3,NRXN1,NEBL,SOX5,FMN2,ZNRF3,MACF1
7.813e-05	-9.46	negative regulation of amyloid precursor protein catabolic process	biological process	GO:1902992	31	3	18204	49	CLU,APOE,NTRK2
7.923e-05	-9.44	cell junction organization	biological process	GO:0034330	532	8	18204	49	NRG3,SPARCL1,SORBS1,APOE,CDH20,CTNND2,GPM6A,NRXN1
8.067e-05	-9.43	organic substance transport	biological process	GO:0071702	1881	15	18204	49	PITPNC1,ATP13A4,SFXN5,NTRK2,RANBP3L,SLC4A4,SLC1A3,SLC25A18,APOE,CAMK2G,CPE,FMN2,MACF1,SLC1A2,CLU
8.215e-05	-9.41	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	6	18094	48	SLC25A18,SLC1A2,SLC1A3,ATP13A4,ATP1A2,SLC4A4
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	GPM6A,NTM,LSAMP
8.356e-05	-9.39	neuron projection development	biological process	GO:0031175	693	9	18204	49	PREX2,BMPR1B,APOE,PTPRZ1,TNIK,GPM6A,CTNNA2,NRXN1,CTNND2
8.364e-05	-9.39	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	49	ATP1A2,SLC4A4,SLC1A2,SLC1A3
8.364e-05	-9.39	vascular transport	biological process	GO:0010232	86	4	18204	49	SLC1A3,SLC1A2,SLC4A4,ATP1A2
8.422e-05	-9.38	leg	COSMIC cancer mutations	leg	969	11	16828	49	COL5A3,NEBL,FGFR3,NRG3,ATP13A4,HIF3A,SLC4A4,ZBTB20,PTPRZ1,FMN2,NTM
8.772e-05	-9.34	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	17	16828	49	NRG3,NKAIN3,NTRK2,RYR3,GPM6A,CTNND2,NEBL,SOX5,SLC1A3,LSAMP,COL5A3,PREX2,SLC1A2,FMN2,CDH20,PTPRZ1,GPC5
8.772e-05	-9.34	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	17	16828	49	GPC5,PTPRZ1,CDH20,FMN2,SLC1A2,PREX2,COL5A3,LSAMP,SLC1A3,SOX5,NEBL,CTNND2,GPM6A,RYR3,NTRK2,NKAIN3,NRG3
8.815e-05	-9.34	organic anion transport	biological process	GO:0015711	398	7	18204	49	SLC4A4,SLC1A2,SLC1A3,NTRK2,APOE,SFXN5,SLC25A18
9.447e-05	-9.27	response to auditory stimulus	biological process	GO:0010996	33	3	18204	49	ATP1A2,SLC1A3,NRXN1
1.023e-04	-9.19	neuron projection	cellular component	GO:0043005	1331	12	19108	49	SLC1A2,CAMK2G,APOE,CLU,GPM6A,SLC1A3,CTNND2,NTRK2,DTNA,ATP1A2,CTNNA2,BMPR1B
1.034e-04	-9.18	negative regulation of amide metabolic process	biological process	GO:0034249	34	3	18204	49	NTRK2,CLU,APOE
1.057e-04	-9.15	D-amino acid transport	biological process	GO:0042940	6	2	18204	49	SLC1A3,SLC1A2
1.057e-04	-9.15	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	49	SLC1A3,SLC1A2
1.191e-04	-9.04	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	9	10285	31	RYR3,ATP1A2,TRPM3,SLC1A2,SLC4A4,ATP13A4,SLC1A3,CAMK2G,SLC25A18
1.275e-04	-8.97	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	30	16828	49	PREX2,TRPM3,MACF1,NRG3,NTRK2,FGFR3,APOE,CTNND2,CAMK2G,CLU,LSAMP,SLC1A2,FMN2,CDH20,PTPRZ1,NHSL1,ZNRF3,GPC5,SPARCL1,PAMR1,RORA,NKAIN3,RYR3,GPM6A,SORBS1,SOX5,NEBL,SLC1A3,COL5A3,NPAS3
1.390e-04	-8.88	carboxylic acid transport	biological process	GO:0046942	297	6	18204	49	SFXN5,SLC1A3,SLC1A2,APOE,SLC25A18,NTRK2
1.416e-04	-8.86	organic acid transport	biological process	GO:0015849	298	6	18204	49	NTRK2,SLC1A2,SLC1A3,SLC25A18,APOE,SFXN5
1.437e-04	-8.85	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	8	18094	48	SLC1A3,SLC1A2,ATP1A2,RYR3,SLC4A4,TRPM3,SLC25A18,GPM6A
1.469e-04	-8.83	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	4	19454	50	CLU,ABLIM1,SPARCL1,SORBS1
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A3,SLC1A2
1.534e-04	-8.78	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	7	18094	48	ATP1A2,SLC1A2,SLC1A3,SLC4A4,RYR3,GPM6A,TRPM3
1.546e-04	-8.77	SDF	pfam domains	PF00375	7	2	17795	49	SLC1A3,SLC1A2
1.565e-04	-8.76	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	49	SLC1A3,SLC1A2,RYR3
1.583e-04	-8.75	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	13	16828	49	NHSL1,FMN2,SLC1A2,PITPNC1,PREX2,CLU,ATP1A2,FGFR3,CTNND2,SLC4A4,SFXN5,ATP13A4,NTRK2
1.583e-04	-8.75	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	13	16828	49	NHSL1,SLC1A2,FMN2,PREX2,PITPNC1,CLU,CTNND2,FGFR3,ATP1A2,SFXN5,ATP13A4,NTRK2,SLC4A4
1.628e-04	-8.72	humerus	COSMIC cancer mutations	humerus	546	8	16828	49	SOX5,NEBL,GPC5,NKAIN3,SFXN5,HIF3A,GPM6A,FMN2
1.712e-04	-8.67	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	7	18204	49	CTNND2,SLC1A3,CTNNA2,NRXN1,PTPRZ1,BMPR1B,PREX2
1.810e-04	-8.62	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	41	16828	49	SORBS1,NEBL,SOX5,SLC25A18,NRXN1,NPAS3,COL5A3,CPE,SPARCL1,PAMR1,RORA,SLC4A4,ATP13A4,NKAIN3,RYR3,GPM6A,PTPRZ1,ABLIM1,ZNRF3,GPC5,FMN2,CDH20,MSI2,CAMK2G,BMPR1B,TNIK,CLU,NRG3,HIF3A,NTRK2,ATP1A2,DTNA,FGFR3,CTNND2,RANBP3L,CST3,MACF1,PREX2,NTM,PITPNC1,TRPM3
1.838e-04	-8.60	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	41	16828	49	RANBP3L,CST3,MACF1,NTM,PITPNC1,PREX2,TRPM3,MSI2,TNIK,BMPR1B,CAMK2G,CLU,NRG3,HIF3A,NTRK2,ATP1A2,DTNA,FGFR3,CTNND2,PTPRZ1,ABLIM1,ZNRF3,GPC5,FMN2,CDH20,SORBS1,SOX5,NEBL,SLC25A18,NPAS3,NRXN1,COL5A3,CPE,SPARCL1,PAMR1,RORA,SLC4A4,NKAIN3,ATP13A4,RYR3,GPM6A
1.841e-04	-8.60	beta-catenin binding	molecular function	GO:0008013	107	4	18094	48	CTNND2,CTNNA2,RORA,CDH20
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	NKAIN3,CTNND2,LSAMP,GPM6A
1.879e-04	-8.58	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	44	SLC1A3,SLC1A2
1.967e-04	-8.53	protein import	biological process	GO:0017038	8	2	18204	49	CLU,APOE
2.035e-04	-8.50	cell projection	cellular component	GO:0042995	2398	16	19108	49	SLC1A2,APOE,CLU,CAMK2G,MACF1,SLC1A3,ABLIM1,CTNND2,NRXN1,FMN2,GPM6A,CTNNA2,ATP1A2,BMPR1B,NTRK2,DTNA
2.060e-04	-8.49	monoatomic ion transport	biological process	GO:0006811	964	10	18204	49	SFXN5,TRPM3,RYR3,ATP13A4,SLC25A18,ATP1A2,SLC1A3,GPM6A,SLC1A2,SLC4A4
2.071e-04	-8.48	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	42	16828	49	PITPNC1,PREX2,NTM,TRPM3,RANBP3L,MACF1,HIF3A,ZBTB20,NTRK2,NRG3,APOE,CTNND2,ATP1A2,DTNA,FGFR3,LSAMP,TNIK,BMPR1B,CDH20,SLC1A2,FMN2,PTPRZ1,ABLIM1,GPC5,ZNRF3,SLC4A4,ATP13A4,SFXN5,NKAIN3,CPE,RORA,PAMR1,RYR3,GPM6A,SORBS1,SOX5,NEBL,NPAS3,COL5A3,NRXN1,SLC25A18,SLC1A3
2.071e-04	-8.48	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	42	16828	49	PTPRZ1,ABLIM1,GPC5,ZNRF3,CDH20,SLC1A2,FMN2,SORBS1,SOX5,NEBL,COL5A3,NPAS3,NRXN1,SLC25A18,SLC1A3,SLC4A4,ATP13A4,NKAIN3,SFXN5,CPE,PAMR1,RORA,RYR3,GPM6A,RANBP3L,MACF1,PITPNC1,NTM,PREX2,TRPM3,LSAMP,BMPR1B,TNIK,ZBTB20,HIF3A,NTRK2,NRG3,APOE,CTNND2,ATP1A2,FGFR3,DTNA
2.247e-04	-8.40	behavior	biological process	GO:0007610	619	8	18204	49	PTPRZ1,APOE,ATP1A2,PREX2,NRXN1,SLC1A2,SLC1A3,NTRK2
2.282e-04	-8.39	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	6	16828	49	SFXN5,NKAIN3,FMN2,GPM6A,SOX5,GPC5
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	LSAMP,NTM
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.333e-04	-8.36	neuronal cell body	cellular component	GO:0043025	489	7	19108	49	BMPR1B,APOE,ATP1A2,GPM6A,SLC1A3,NRXN1,CTNND2
2.383e-04	-8.34	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	29	16828	49	PTPRZ1,ZNRF3,GPC5,CDH20,FMN2,SOX5,NEBL,SORBS1,COL5A3,NPAS3,SLC1A3,SLC25A18,NKAIN3,ATP13A4,SLC4A4,PAMR1,GPM6A,RYR3,MACF1,CST3,NTM,TRPM3,LSAMP,CLU,NTRK2,NRG3,CTNND2,DTNA,ATP1A2
2.383e-04	-8.34	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	29	16828	49	SLC1A3,SLC25A18,COL5A3,NPAS3,NEBL,SOX5,SORBS1,GPM6A,RYR3,PAMR1,NKAIN3,ATP13A4,SLC4A4,GPC5,ZNRF3,PTPRZ1,FMN2,CDH20,CLU,LSAMP,DTNA,ATP1A2,CTNND2,NRG3,NTRK2,CST3,MACF1,TRPM3,NTM
2.480e-04	-8.30	adenoma	COSMIC cancer mutations	adenoma	2873	19	16828	49	NPAS3,COL5A3,BMPR1B,NEBL,SOX5,ACSS1,RYR3,APOE,GPM6A,CTNND2,FGFR3,HIF3A,ZBTB20,NTRK2,MACF1,GPC5,PTPRZ1,CDH20,TRPM3
2.521e-04	-8.29	somatodendritic compartment	cellular component	GO:0036477	842	9	19108	49	GPM6A,SLC1A3,NRXN1,CTNND2,NTRK2,BMPR1B,APOE,ATP1A2,CLU
2.582e-04	-8.26	synapse organization	biological process	GO:0050808	333	6	18204	49	NRG3,GPM6A,NRXN1,SPARCL1,CTNND2,APOE
2.594e-04	-8.26	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	4	18094	48	SLC4A4,SLC25A18,SLC1A2,SLC1A3
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	44	SLC1A3,SLC1A2
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	44	SLC1A3,SLC1A2
2.660e-04	-8.23	central nervous system development	biological process	GO:0007417	995	10	18204	49	BMPR1B,ATP1A2,NRG3,PTPRZ1,MSI2,RORA,NTRK2,CTNNA2,SLC1A2,CLU
2.700e-04	-8.22	monoatomic cation transmembrane transport	biological process	GO:0098655	636	8	18204	49	TRPM3,SLC25A18,ATP1A2,ATP13A4,RYR3,SLC1A3,GPM6A,SLC4A4
2.806e-04	-8.18	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	4	10285	31	SLC4A4,SLC1A3,SLC25A18,SLC1A2
2.904e-04	-8.14	membrane	cellular component	GO:0016020	9220	36	19108	49	ATP1A2,NRXN1,CTNND2,SLC1A3,CST3,CLU,SLC25A18,CDH20,PREX2,NTM,CPE,CAMK2G,ATP13A4,LSAMP,RYR3,FGFR3,NKAIN3,BMPR1B,CTNNA2,HIF3A,NTRK2,DTNA,FMN2,GPM6A,TRPM3,PTPRZ1,APOE,MACF1,SORBS1,NRG3,SLC4A4,SLC1A2,TNIK,SFXN5,GPC5,ZNRF3
2.911e-04	-8.14	regulation of amyloid-beta formation	biological process	GO:1902003	48	3	18204	49	NTRK2,APOE,CLU
3.017e-04	-8.11	cell-cell signaling	biological process	GO:0007267	822	9	18204	49	DTNA,SLC1A2,SLC1A3,NRXN1,CPE,NTRK2,CAMK2G,FGFR3,APOE
3.095e-04	-8.08	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	24	16828	49	FMN2,CDH20,NHSL1,PTPRZ1,ATP13A4,SLC4A4,GPM6A,RYR3,ACSS1,SOX5,SORBS1,COL5A3,NTM,PREX2,TRPM3,RANBP3L,MACF1,NRG3,NTRK2,HIF3A,ZBTB20,FGFR3,CTNND2,TNIK
3.150e-04	-8.06	cellular response to cocaine	biological process	GO:0071314	10	2	18204	49	SLC1A2,SLC1A3
3.150e-04	-8.06	action potential propagation	biological process	GO:0098870	10	2	18204	49	NTRK2,ATP1A2
3.150e-04	-8.06	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	49	ATP1A2,NTRK2
3.190e-04	-8.05	EDTRNSPORT	prints domains	PR00173	7	2	5227	21	SLC1A3,SLC1A2
3.234e-04	-8.04	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	31	16828	49	CLU,NRG3,HIF3A,ZBTB20,FGFR3,CTNND2,APOE,MACF1,NTM,PITPNC1,PREX2,TRPM3,ACSS1,SOX5,SORBS1,SLC1A3,SLC25A18,NPAS3,COL5A3,PAMR1,RORA,SFXN5,SLC4A4,GPM6A,RYR3,NHSL1,ABLIM1,GPC5,FMN2,SLC1A2,CDH20
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	SOX5,PREX2,SLC1A2,RYR3
3.648e-04	-7.92	Ion channel transport	REACTOME pathways	R-HSA-983712	209	5	10285	31	ATP1A2,ATP13A4,RYR3,TRPM3,CAMK2G
3.844e-04	-7.86	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	49	SLC1A2,SLC1A3
3.918e-04	-7.84	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	31	16828	49	PTPRZ1,ABLIM1,GPC5,FMN2,SORBS1,NEBL,SOX5,NRXN1,NPAS3,COL5A3,SLC25A18,SLC4A4,ATP13A4,SFXN5,SPARCL1,CPE,RYR3,GPM6A,RANBP3L,MACF1,PITPNC1,PREX2,TRPM3,TNIK,BMPR1B,ZBTB20,HIF3A,NRG3,CTNND2,ATP1A2,FGFR3
4.023e-04	-7.82	CSTL1 (cystatin like 1)	protein interactions	128817	56	3	19454	50	CPE,APOE,CLU
4.044e-04	-7.81	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	15	16828	49	SORBS1,NEBL,BMPR1B,COL5A3,NRG3,CPE,SPARCL1,RORA,ATP13A4,ATP1A2,FGFR3,CTNND2,ABLIM1,PREX2,FMN2
4.044e-04	-7.81	mucosal	COSMIC cancer mutations	mucosal	2009	15	16828	49	ABLIM1,FMN2,PREX2,COL5A3,BMPR1B,SORBS1,NEBL,CTNND2,ATP1A2,FGFR3,ATP13A4,CPE,SPARCL1,NRG3,RORA
4.129e-04	-7.79	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	15	19108	49	SLC1A2,CLU,APOE,MACF1,CAMK2G,CTNND2,FMN2,ABLIM1,SLC1A3,GPM6A,ATP1A2,CTNNA2,BMPR1B,DTNA,NTRK2
4.203e-04	-7.77	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	2	19454	50	APOE,CLU
4.218e-04	-7.77	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	18	16828	49	PREX2,FMN2,SLC1A2,ZNRF3,GPC5,NTRK2,SFXN5,NKAIN3,HIF3A,NRG3,CPE,CTNND2,GPM6A,RYR3,SOX5,NEBL,LSAMP,SLC1A3
4.357e-04	-7.74	regulation of amyloid precursor protein catabolic process	biological process	GO:1902991	55	3	18204	49	CLU,APOE,NTRK2
4.404e-04	-7.73	Ig_I-set	interpro domains	IPR013098	132	4	18521	50	FGFR3,NTM,NTRK2,LSAMP
4.465e-04	-7.71	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	21	16828	49	COL5A3,TNIK,SOX5,NEBL,RYR3,CTNND2,GPM6A,ATP1A2,SLC4A4,ZBTB20,NRG3,SPARCL1,PAMR1,MACF1,GPC5,PTPRZ1,NHSL1,ABLIM1,FMN2,TRPM3,PREX2
4.501e-04	-7.71	middle_third	COSMIC cancer mutations	middle_third	3533	21	16828	49	GPC5,MACF1,PTPRZ1,ABLIM1,NHSL1,FMN2,TRPM3,PREX2,TNIK,COL5A3,SOX5,NEBL,ATP1A2,RYR3,GPM6A,CTNND2,NRG3,SPARCL1,PAMR1,ZBTB20,SLC4A4
4.605e-04	-7.68	auditory behavior	biological process	GO:0031223	12	2	18204	49	NRXN1,SLC1A3
4.673e-04	-7.67	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	15	16828	49	MSI2,NEBL,LSAMP,NRG3,RORA,GPM6A,FGFR3,PTPRZ1,ABLIM1,MACF1,GPC5,ZNRF3,PREX2,FMN2,TRPM3
4.733e-04	-7.66	I-set	pfam domains	PF07679	132	4	17795	49	NTRK2,LSAMP,FGFR3,NTM
4.895e-04	-7.62	trunk	COSMIC cancer mutations	trunk	3554	21	16828	49	HIF3A,NTRK2,ATP13A4,CPE,NRG3,SPARCL1,RYR3,CTNND2,ATP1A2,FGFR3,SOX5,NEBL,NPAS3,NRXN1,LSAMP,SLC1A3,PREX2,CDH20,PTPRZ1,ABLIM1,MACF1
5.080e-04	-7.58	regulation of synapse organization	biological process	GO:0050807	246	5	18204	49	NTRK2,APOE,NRXN1,GPM6A,CTNNA2
5.090e-04	-7.58	Calml3 (calmodulin-like 3)	protein interactions	70405	144	4	19454	50	CAMK2G,ZBTB20,ABLIM1,MACF1
5.095e-04	-7.58	nitrogen compound transport	biological process	GO:0071705	1507	12	18204	49	SLC1A3,NTRK2,RANBP3L,ATP13A4,CPE,FMN2,MACF1,CLU,SLC1A2,CAMK2G,APOE,SLC25A18
5.182e-04	-7.57	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	33	16828	49	NTRK2,NRG3,APOE,CTNND2,ATP1A2,FGFR3,CLU,LSAMP,BMPR1B,PREX2,RANBP3L,MACF1,SLC4A4,ATP13A4,NKAIN3,SFXN5,CPE,PAMR1,RORA,RYR3,GPM6A,SOX5,NEBL,ACSS1,COL5A3,SLC25A18,SLC1A3,CDH20,SLC1A2,FMN2,ABLIM1,NHSL1,GPC5
5.266e-04	-7.55	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	8	18094	48	SLC4A4,RYR3,ATP1A2,SLC25A18,SLC1A2,TRPM3,SLC1A3,GPM6A
5.428e-04	-7.52	neurotransmitter transport	biological process	GO:0006836	140	4	18204	49	NRXN1,SLC1A2,SLC1A3,ATP1A2
5.432e-04	-7.52	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	2	18204	49	APOE,CLU
5.442e-04	-7.52	NAKATPASE	prints domains	PR00121	9	2	5227	21	ATP1A2,ATP13A4
5.584e-04	-7.49	transmembrane transporter activity	molecular function	GO:0022857	1110	10	18094	48	GPM6A,TRPM3,SLC25A18,ATP13A4,SFXN5,SLC1A3,SLC1A2,ATP1A2,RYR3,SLC4A4
5.668e-04	-7.48	regulation of synapse structure or activity	biological process	GO:0050803	252	5	18204	49	NTRK2,APOE,NRXN1,CTNNA2,GPM6A
5.726e-04	-7.47	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	4	18204	49	ZBTB20,APOE,SLC4A4,SORBS1
5.776e-04	-7.46	PLXNA4 (plexin A4)	protein interactions	91584	14	2	19454	50	CLU,GPM6A
5.776e-04	-7.46	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	2	19454	50	CAMK2G,ZBTB20
5.776e-04	-7.46	C9 (complement C9)	protein interactions	735	14	2	19454	50	CLU,APOE
6.143e-04	-7.40	gallbladder	COSMIC cancer mutations	gallbladder	2821	18	16828	49	ZNRF3,MACF1,PTPRZ1,NHSL1,FMN2,TRPM3,PREX2,PITPNC1,TNIK,COL5A3,CLU,FGFR3,RYR3,CTNND2,NRG3,SPARCL1,SLC4A4,NKAIN3
6.143e-04	-7.40	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	18	16828	49	TNIK,COL5A3,CLU,SPARCL1,NRG3,NKAIN3,SLC4A4,FGFR3,CTNND2,RYR3,NHSL1,PTPRZ1,ZNRF3,MACF1,PITPNC1,PREX2,TRPM3,FMN2
6.144e-04	-7.39	transport	biological process	GO:0006810	3615	20	18204	49	PITPNC1,RYR3,ATP13A4,SFXN5,NTRK2,RANBP3L,SLC4A4,NRXN1,SLC1A3,ATP1A2,SLC25A18,APOE,TRPM3,CAMK2G,MACF1,CPE,FMN2,SLC1A2,GPM6A,CLU
6.169e-04	-7.39	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	3	10285	31	CAMK2G,RYR3,ATP1A2
6.187e-04	-7.39	glutamatergic synapse	cellular component	GO:0098978	412	6	19108	49	SPARCL1,GPM6A,APOE,TNIK,SLC1A2,NRG3
6.323e-04	-7.37	symporter activity	molecular function	GO:0015293	148	4	18094	48	SLC4A4,SLC1A3,SLC25A18,SLC1A2
6.327e-04	-7.37	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	49	SLC4A4,ATP1A2
6.327e-04	-7.37	mechanosensory behavior	biological process	GO:0007638	14	2	18204	49	NRXN1,SLC1A3
6.356e-04	-7.36	adult behavior	biological process	GO:0030534	146	4	18204	49	ATP1A2,PREX2,NRXN1,SLC1A2
6.412e-04	-7.35	cell adhesion molecule binding	molecular function	GO:0050839	560	7	18094	48	CTNND2,CPE,MACF1,PTPRZ1,CTNNA2,NRXN1,CDH20
6.523e-04	-7.34	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	3	19454	50	APOE,CLU,SFXN5
6.542e-04	-7.33	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	47	16828	49	CST3,MACF1,DTNA,FGFR3,ATP1A2,NRG3,HIF3A,CAMK2G,BMPR1B,FMN2,ABLIM1,PTPRZ1,RORA,SLC4A4,SLC1A3,ACSS1,NEBL,SOX5,TRPM3,NTM,PREX2,PITPNC1,RANBP3L,CTNND2,APOE,NTRK2,ZBTB20,TNIK,CLU,LSAMP,MSI2,SLC1A2,CDH20,ZNRF3,GPC5,NHSL1,GPM6A,RYR3,PAMR1,SFXN5,ATP13A4,NKAIN3,SLC25A18,NRXN1,NPAS3,COL5A3,SORBS1
6.642e-04	-7.32	ACTB (actin beta)	protein interactions	60	958	9	19454	50	APOE,SFXN5,NEBL,FMN2,MACF1,NHSL1,ABLIM1,SORBS1,DTNA
6.654e-04	-7.32	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	2	19454	50	CPE,CLU
6.803e-04	-7.29	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	49	PREX2,CTNNA2,CTNND2
6.839e-04	-7.29	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	3	10285	31	ATP13A4,ATP1A2,CAMK2G
6.989e-04	-7.27	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	5	18094	48	SLC4A4,SFXN5,SLC1A3,SLC25A18,SLC1A2
7.130e-04	-7.25	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	3	18094	48	SLC1A2,SLC25A18,SLC1A3
7.444e-04	-7.20	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	3	18204	49	SLC25A18,SLC1A2,SLC1A3
7.549e-04	-7.19	collagen-containing extracellular matrix	cellular component	GO:0062023	428	6	19108	49	APOE,COL5A3,CLU,SPARCL1,GPC5,PTPRZ1
7.592e-04	-7.18	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	2	19454	50	MACF1,CPE
7.916e-04	-7.14	face	COSMIC cancer mutations	face	2139	15	16828	49	PTPRZ1,ABLIM1,GPC5,ZNRF3,MACF1,PREX2,FMN2,TRPM3,MSI2,NEBL,LSAMP,NRG3,RORA,FGFR3,GPM6A
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	SLC4A4,SLC1A3,SLC1A2,ATP1A2
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	LSAMP,ZBTB20
8.111e-04	-7.12	cell adhesion	biological process	GO:0007155	942	9	18204	49	SPARCL1,SORBS1,COL5A3,LSAMP,CTNND2,NTM,CDH20,NRXN1,CTNNA2
8.133e-04	-7.11	vascular process in circulatory system	biological process	GO:0003018	273	5	18204	49	ATP1A2,SLC1A2,SLC1A3,SLC4A4,APOE
8.315e-04	-7.09	locomotory exploration behavior	biological process	GO:0035641	16	2	18204	49	APOE,ATP1A2
8.443e-04	-7.08	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	10	18204	49	TNIK,CTNND2,NRXN1,CTNNA2,GPM6A,BMPR1B,PREX2,ABLIM1,PTPRZ1,APOE
8.516e-04	-7.07	spindle	COSMIC cancer mutations	spindle	386	6	16828	49	MACF1,CTNND2,TRPM3,FGFR3,PREX2,CPE
8.541e-04	-7.07	learning or memory	biological process	GO:0007611	276	5	18204	49	APOE,NRXN1,PTPRZ1,NTRK2,ATP1A2
8.727e-04	-7.04	intracellular chemical homeostasis	biological process	GO:0055082	581	7	18204	49	ATP1A2,RYR3,ATP13A4,ZBTB20,APOE,SLC1A3,SLC4A4
9.247e-04	-6.99	monoatomic cation transport	biological process	GO:0006812	766	8	18204	49	TRPM3,SLC25A18,ATP1A2,ATP13A4,RYR3,GPM6A,SLC1A3,SLC4A4
9.296e-04	-6.98	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	16	16828	49	PAMR1,SPARCL1,FGFR3,RYR3,APOE,SORBS1,SLC1A3,NPAS3,CLU,PREX2,TRPM3,FMN2,CDH20,NHSL1,ZNRF3,MACF1
9.296e-04	-6.98	alveolar	COSMIC cancer mutations	alveolar	2414	16	16828	49	NPAS3,CLU,SLC1A3,SORBS1,APOE,RYR3,FGFR3,SPARCL1,PAMR1,MACF1,ZNRF3,NHSL1,CDH20,FMN2,TRPM3,PREX2
9.407e-04	-6.97	reverse cholesterol transport	biological process	GO:0043691	17	2	18204	49	APOE,CLU
9.407e-04	-6.97	regulation of amyloid fibril formation	biological process	GO:1905906	17	2	18204	49	APOE,CLU
9.443e-04	-6.97	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	22	16828	49	SLC1A2,FMN2,PREX2,PITPNC1,ZNRF3,MACF1,NHSL1,PTPRZ1,FGFR3,ATP1A2,CTNND2,GPM6A,RYR3,NTRK2,SLC4A4,HIF3A,CAMK2G,TNIK,COL5A3,NPAS3,ACSS1,NEBL
9.479e-04	-6.96	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	44	16828	49	RANBP3L,TRPM3,PREX2,PITPNC1,NTM,LSAMP,TNIK,CTNND2,NTRK2,ZBTB20,GPC5,ZNRF3,NHSL1,CDH20,SLC1A2,COL5A3,NRXN1,NPAS3,SLC25A18,SORBS1,GPM6A,RYR3,SFXN5,ATP13A4,PAMR1,SPARCL1,MACF1,CST3,BMPR1B,FGFR3,DTNA,ATP1A2,HIF3A,NRG3,ABLIM1,PTPRZ1,FMN2,SLC1A3,NEBL,SOX5,ACSS1,SLC4A4,RORA,CPE
9.554e-04	-6.95	Wnt signaling pathway	biological process	GO:0016055	283	5	18204	49	TNIK,CTNND2,ZNRF3,CPE,MACF1
9.587e-04	-6.95	cervix	COSMIC cancer mutations	cervix	11793	44	16828	49	ABLIM1,PTPRZ1,FMN2,SLC1A3,SOX5,NEBL,ACSS1,SLC4A4,RORA,CPE,MACF1,CST3,BMPR1B,DTNA,FGFR3,ATP1A2,HIF3A,NRG3,ZNRF3,GPC5,NHSL1,CDH20,SLC1A2,NRXN1,NPAS3,COL5A3,SLC25A18,SORBS1,GPM6A,RYR3,ATP13A4,SFXN5,PAMR1,SPARCL1,RANBP3L,TRPM3,PITPNC1,PREX2,NTM,LSAMP,TNIK,CTNND2,NTRK2,ZBTB20
9.621e-04	-6.95	dendrite	cellular component	GO:0030425	620	7	19108	49	GPM6A,CTNND2,NTRK2,ATP1A2,APOE,BMPR1B,CLU
9.623e-04	-6.95	actin binding	molecular function	GO:0003779	434	6	18094	48	CTNNA2,FMN2,MACF1,SORBS1,ABLIM1,NEBL
9.696e-04	-6.94	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	6	18204	49	SLC4A4,SLC1A3,ATP1A2,RYR3,ATP13A4,APOE
9.763e-04	-6.93	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	5	16828	49	PREX2,SOX5,FGFR3,SLC1A2,RYR3
9.803e-04	-6.93	dendritic tree	cellular component	GO:0097447	622	7	19108	49	CTNND2,GPM6A,APOE,ATP1A2,BMPR1B,CLU,NTRK2
9.825e-04	-6.93	signaling	biological process	GO:0023052	4968	24	18204	49	PITPNC1,RYR3,PREX2,SORBS1,RORA,FGFR3,NTRK2,TNIK,CTNND2,SLC1A3,NRXN1,DTNA,NRG3,BMPR1B,ATP1A2,APOE,SPARCL1,CAMK2G,FMN2,ZNRF3,MACF1,CPE,CLU,SLC1A2
9.860e-04	-6.92	cell junction assembly	biological process	GO:0034329	285	5	18204	49	NRG3,SORBS1,CDH20,GPM6A,NRXN1
1.005e-03	-6.90	trans-synaptic signaling	biological process	GO:0099537	431	6	18204	49	DTNA,NRXN1,SLC1A3,SLC1A2,APOE,NTRK2
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	GPM6A,NTM,LSAMP
1.030e-03	-6.88	FLOT1 (flotillin 1)	protein interactions	10211	453	6	19454	50	ABLIM1,SOX5,FMN2,DTNA,SORBS1,MACF1
1.053e-03	-6.86	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	6	19454	50	DTNA,CTNND2,SLC25A18,CAMK2G,FMN2,MACF1
1.061e-03	-6.85	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	3	19454	50	SOX5,SLC25A18,MSI2
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP1A2,ATP13A4
1.079e-03	-6.83	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	6	18204	49	ATP1A2,ATP13A4,RYR3,APOE,SLC4A4,SLC1A3
1.082e-03	-6.83	active transmembrane transporter activity	molecular function	GO:0022804	444	6	18094	48	SLC4A4,ATP1A2,SLC1A2,SLC1A3,ATP13A4,SLC25A18
1.105e-03	-6.81	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	49	ATP1A2,ATP13A4
1.118e-03	-6.80	cell communication	biological process	GO:0007154	5010	24	18204	49	NRG3,CPE,CLU,SORBS1,PITPNC1,DTNA,CTNND2,TNIK,APOE,SPARCL1,ATP1A2,BMPR1B,MACF1,FMN2,ZNRF3,SLC1A2,CAMK2G,RORA,FGFR3,PREX2,RYR3,SLC1A3,NRXN1,NTRK2
1.154e-03	-6.76	cell projection organization	biological process	GO:0030030	1200	10	18204	49	CTNNA2,NRXN1,GPM6A,CTNND2,TNIK,PTPRZ1,APOE,PREX2,ABLIM1,BMPR1B
1.158e-03	-6.76	regulation of neuron projection development	biological process	GO:0010975	443	6	18204	49	TNIK,CAMK2G,NTRK2,MACF1,CTNNA2,APOE
1.172e-03	-6.75	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	5	19454	50	ABLIM1,TNIK,FMN2,DTNA,MACF1
1.179e-03	-6.74	regulation of amyloid-beta clearance	biological process	GO:1900221	19	2	18204	49	CLU,APOE
1.179e-03	-6.74	cartilage condensation	biological process	GO:0001502	19	2	18204	49	SOX5,BMPR1B
1.186e-03	-6.74	PAS_fold	interpro domains	IPR013767	19	2	18521	50	NPAS3,HIF3A
1.190e-03	-6.73	endoplasmic reticulum lumen	cellular component	GO:0005788	312	5	19108	49	CST3,SPARCL1,APOE,COL5A3,CLU
1.194e-03	-6.73	PON1 (paraoxonase 1)	protein interactions	5444	20	2	19454	50	SFXN5,CLU
1.210e-03	-6.72	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	3	18204	49	SLC4A4,ZBTB20,SORBS1
1.233e-03	-6.70	PAS	pfam domains	PF00989	19	2	17795	49	NPAS3,HIF3A
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC4A4,SLC1A3,SLC1A2
1.250e-03	-6.68	inorganic cation transmembrane transport	biological process	GO:0098662	618	7	18204	49	SLC25A18,ATP1A2,RYR3,TRPM3,SLC1A3,GPM6A,SLC4A4
1.293e-03	-6.65	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	3	18094	48	BMPR1B,FGFR3,NTRK2
1.303e-03	-6.64	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	32	16828	49	RYR3,SLC4A4,SFXN5,ATP13A4,RORA,NPAS3,COL5A3,NRXN1,NEBL,SOX5,ACSS1,CDH20,SLC1A2,FMN2,ZNRF3,PTPRZ1,NHSL1,CTNND2,ATP1A2,FGFR3,ZBTB20,NTRK2,NRG3,CLU,LSAMP,TRPM3,NTM,PITPNC1,PREX2,MACF1,CST3,RANBP3L
1.303e-03	-6.64	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	32	16828	49	MACF1,CST3,RANBP3L,TRPM3,PREX2,NTM,PITPNC1,LSAMP,CLU,CTNND2,FGFR3,ATP1A2,NTRK2,ZBTB20,NRG3,ZNRF3,NHSL1,PTPRZ1,CDH20,FMN2,SLC1A2,NRXN1,COL5A3,NPAS3,SOX5,NEBL,ACSS1,RYR3,SFXN5,ATP13A4,SLC4A4,RORA
1.307e-03	-6.64	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	49	SOX5,BMPR1B
1.314e-03	-6.63	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	8	16828	49	SLC1A3,ACSS1,SOX5,NEBL,RANBP3L,DTNA,CTNND2,NTRK2
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	MACF1,SORBS1
1.349e-03	-6.61	regulation of amide metabolic process	biological process	GO:0034248	81	3	18204	49	NTRK2,CLU,APOE
1.361e-03	-6.60	adherens junction	cellular component	GO:0005912	188	4	19108	49	CTNND2,CDH20,CTNNA2,SORBS1
1.389e-03	-6.58	synaptic signaling	biological process	GO:0099536	459	6	18204	49	SLC1A2,SLC1A3,DTNA,NRXN1,APOE,NTRK2
1.397e-03	-6.57	contractile actin filament bundle	cellular component	GO:0097517	86	3	19108	49	ABLIM1,NEBL,SORBS1
1.397e-03	-6.57	stress fiber	cellular component	GO:0001725	86	3	19108	49	ABLIM1,NEBL,SORBS1
1.414e-03	-6.56	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	12	18204	49	RORA,SFXN5,NTRK2,NRXN1,ATP1A2,BMPR1B,ZBTB20,APOE,PTPRZ1,SOX5,MACF1,CLU
1.443e-03	-6.54	positive regulation of glycolytic process	biological process	GO:0045821	21	2	18204	49	SLC4A4,ZBTB20
1.443e-03	-6.54	cell aggregation	biological process	GO:0098743	21	2	18204	49	SOX5,BMPR1B
1.443e-03	-6.54	positive regulation of purine nucleotide catabolic process	biological process	GO:0033123	21	2	18204	49	SLC4A4,ZBTB20
1.443e-03	-6.54	positive regulation of nucleotide catabolic process	biological process	GO:0030813	21	2	18204	49	SLC4A4,ZBTB20
1.459e-03	-6.53	uveal_tract	COSMIC cancer mutations	uveal_tract	587	7	16828	49	MACF1,RANBP3L,TRPM3,FGFR3,CTNND2,CPE,PREX2
1.471e-03	-6.52	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	4	18204	49	SORBS1,RORA,ZBTB20,SLC4A4
1.478e-03	-6.52	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	4	18094	48	SFXN5,SLC1A3,SLC25A18,SLC1A2
1.498e-03	-6.50	L-amino acid transport	biological process	GO:0015807	84	3	18204	49	SLC1A2,SLC1A3,SLC25A18
1.507e-03	-6.50	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	4	18094	48	SFXN5,SLC1A2,SLC25A18,SLC1A3
1.550e-03	-6.47	Cation_ATPase_N	smart domains	SM00831	16	2	9717	36	ATP1A2,ATP13A4
1.550e-03	-6.47	oligodendrocyte differentiation	biological process	GO:0048709	85	3	18204	49	NTRK2,CLU,PTPRZ1
1.550e-03	-6.47	chondrocyte differentiation	biological process	GO:0002062	85	3	18204	49	BMPR1B,FGFR3,SOX5
1.584e-03	-6.45	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	49	ATP1A2,SLC1A3
1.594e-03	-6.44	DEP_dom	interpro domains	IPR000591	22	2	18521	50	FMN2,PREX2
1.595e-03	-6.44	establishment of localization	biological process	GO:0051234	3887	20	18204	49	FMN2,MACF1,CPE,GPM6A,CLU,SLC1A2,CAMK2G,TRPM3,APOE,SLC25A18,ATP1A2,SLC4A4,SLC1A3,NRXN1,NTRK2,RANBP3L,SFXN5,PITPNC1,RYR3,ATP13A4
1.620e-03	-6.43	OCLN (occludin)	protein interactions	100506658	495	6	19454	50	DTNA,ABLIM1,MACF1,FMN2,NTRK2,TNIK
1.624e-03	-6.42	cognition	biological process	GO:0050890	319	5	18204	49	APOE,NRXN1,PTPRZ1,NTRK2,ATP1A2
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A3,SLC1A2
1.689e-03	-6.38	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	12	16828	49	RORA,SLC4A4,ATP13A4,ATP1A2,FGFR3,PTPRZ1,SOX5,GPC5,COL5A3,LSAMP,MACF1,NRXN1
1.695e-03	-6.38	actomyosin	cellular component	GO:0042641	92	3	19108	49	ABLIM1,SORBS1,NEBL
1.696e-03	-6.38	amyloid-beta binding	molecular function	GO:0001540	89	3	18094	48	CLU,APOE,CST3
1.708e-03	-6.37	transmembrane transport	biological process	GO:0055085	1264	10	18204	49	RYR3,ATP13A4,SLC25A18,ATP1A2,SFXN5,TRPM3,SLC1A3,SLC1A2,GPM6A,SLC4A4
1.715e-03	-6.37	human chr5p13.2	chromosome location	human chr5p13.2	32	2	26134	50	SLC1A3,RANBP3L
1.750e-03	-6.35	eye	COSMIC cancer mutations	eye	606	7	16828	49	CTNND2,TRPM3,FGFR3,PREX2,CPE,MACF1,RANBP3L
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	ATP1A2,RYR3,DTNA,CAMK2G
1.769e-03	-6.34	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	3	18204	49	SORBS1,APOE,ZBTB20
1.781e-03	-6.33	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	49	MACF1,CST3,RANBP3L,TRPM3,PREX2,NTM,LSAMP,CLU,TNIK,CAMK2G,BMPR1B,MSI2,CTNND2,DTNA,FGFR3,ATP1A2,NTRK2,ZBTB20,NRG3,ZNRF3,GPC5,NHSL1,PTPRZ1,CDH20,SLC1A2,FMN2,NRXN1,COL5A3,NPAS3,SLC1A3,NEBL,SOX5,SORBS1,ACSS1,RYR3,ATP13A4,SFXN5,SLC4A4,RORA,PAMR1,CPE
1.817e-03	-6.31	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	3	19454	50	CAMK2G,FGFR3,NTRK2
1.832e-03	-6.30	low-density lipoprotein particle receptor binding	molecular function	GO:0050750	24	2	18094	48	CLU,APOE
1.832e-03	-6.30	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	48	ATP13A4,ATP1A2
1.832e-03	-6.30	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	48	ATP1A2,ATP13A4
1.837e-03	-6.30	export from cell	biological process	GO:0140352	485	6	18204	49	ATP1A2,CAMK2G,NTRK2,NRXN1,SLC4A4,CPE
1.848e-03	-6.29	cell surface	cellular component	GO:0009986	896	8	19108	49	FGFR3,GPC5,NRXN1,SLC4A4,SLC1A2,SLC1A3,CLU,ATP1A2
1.907e-03	-6.26	SNCA (synuclein alpha)	protein interactions	6622	696	7	19454	50	CLU,TNIK,APOE,MACF1,GPM6A,NTRK2,CAMK2G
1.909e-03	-6.26	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	12	16828	49	PREX2,FMN2,CDH20,PTPRZ1,ABLIM1,MACF1,CPE,RORA,DTNA,FGFR3,CTNND2,SORBS1
1.909e-03	-6.26	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	12	16828	49	FMN2,DTNA,FGFR3,CTNND2,CDH20,CPE,RORA,PREX2,MACF1,PTPRZ1,SORBS1,ABLIM1
1.909e-03	-6.26	regulation of small molecule metabolic process	biological process	GO:0062012	331	5	18204	49	SLC4A4,APOE,RORA,ZBTB20,SORBS1
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.915e-03	-6.26	actin filament bundle	cellular component	GO:0032432	96	3	19108	49	ABLIM1,NEBL,SORBS1
1.918e-03	-6.26	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	7	18204	49	APOE,CTNNA2,GPM6A,MACF1,NTRK2,CAMK2G,TNIK
1.920e-03	-6.26	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	28	16828	49	HIF3A,ZBTB20,NTRK2,NRG3,ATP1A2,FGFR3,DTNA,CLU,CAMK2G,PREX2,TRPM3,MACF1,SLC4A4,SFXN5,ATP13A4,SPARCL1,GPM6A,SORBS1,NEBL,ACSS1,NRXN1,COL5A3,SLC1A3,CDH20,FMN2,PTPRZ1,ABLIM1,GPC5
1.931e-03	-6.25	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	28	16828	49	GPC5,ABLIM1,PTPRZ1,FMN2,CDH20,SLC1A3,COL5A3,NRXN1,ACSS1,NEBL,SORBS1,GPM6A,SPARCL1,ATP13A4,SFXN5,SLC4A4,MACF1,TRPM3,PREX2,CAMK2G,CLU,DTNA,FGFR3,ATP1A2,NRG3,NTRK2,ZBTB20,HIF3A
2.013e-03	-6.21	high-density lipoprotein particle	cellular component	GO:0034364	26	2	19108	49	CLU,APOE
2.015e-03	-6.21	modulation of chemical synaptic transmission	biological process	GO:0050804	494	6	18204	49	NTRK2,SLC1A3,NRXN1,NRG3,ATP1A2,APOE
2.021e-03	-6.20	skin-face-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-face-malignant_melanoma-lentigo_maligna	23	2	16828	49	PREX2,FGFR3
2.035e-03	-6.20	regulation of trans-synaptic signaling	biological process	GO:0099177	495	6	18204	49	ATP1A2,NTRK2,NRG3,NRXN1,SLC1A3,APOE
2.045e-03	-6.19	actin cytoskeleton	cellular component	GO:0015629	520	6	19108	49	FMN2,ABLIM1,CTNNA2,NEBL,MACF1,SORBS1
2.047e-03	-6.19	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	3	19454	50	SORBS1,NTRK2,FGFR3
2.118e-03	-6.16	regulation of Wnt signaling pathway	biological process	GO:0030111	339	5	18204	49	CTNND2,APOE,MACF1,ZNRF3,GPC5
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	DTNA,CTNNA2,CDH20
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	ABLIM1,DTNA
2.185e-03	-6.13	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	7	19454	50	ABLIM1,SLC1A3,DTNA,MSI2,TNIK,FMN2,MACF1
2.200e-03	-6.12	EZR (ezrin)	protein interactions	7430	526	6	19454	50	MACF1,DTNA,NEBL,SORBS1,TNIK,ABLIM1
2.212e-03	-6.11	regulation of cell projection organization	biological process	GO:0031344	683	7	18204	49	TNIK,CAMK2G,NTRK2,MACF1,GPM6A,CTNNA2,APOE
2.220e-03	-6.11	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	21	16828	49	MACF1,ZNRF3,PTPRZ1,FMN2,SLC1A2,PREX2,PITPNC1,COL5A3,NPAS3,CAMK2G,TNIK,NEBL,ACSS1,RYR3,CTNND2,GPM6A,ATP1A2,FGFR3,SLC4A4,HIF3A,NTRK2
2.227e-03	-6.11	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	21	16828	49	PTPRZ1,ZNRF3,MACF1,PITPNC1,PREX2,SLC1A2,FMN2,ACSS1,NEBL,TNIK,CAMK2G,COL5A3,NPAS3,SLC4A4,HIF3A,NTRK2,ATP1A2,FGFR3,RYR3,GPM6A,CTNND2
2.250e-03	-6.10	monoatomic cation homeostasis	biological process	GO:0055080	505	6	18204	49	ATP1A2,ATP13A4,RYR3,APOE,SLC1A3,SLC4A4
2.261e-03	-6.09	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	7	16828	49	PREX2,NTM,FMN2,NEBL,PTPRZ1,SORBS1,CAMK2G
2.262e-03	-6.09	amino acid transmembrane transport	biological process	GO:0003333	97	3	18204	49	SLC1A3,SLC1A2,SLC25A18
2.302e-03	-6.07	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	32	16828	49	SLC1A3,COL5A3,NRXN1,NPAS3,ACSS1,SORBS1,SOX5,NEBL,RYR3,SPARCL1,RORA,PAMR1,SLC4A4,NKAIN3,ATP13A4,PTPRZ1,ABLIM1,FMN2,CAMK2G,TNIK,ATP1A2,FGFR3,DTNA,CTNND2,NRG3,ZBTB20,HIF3A,NTRK2,CST3,MACF1,TRPM3,PREX2
2.324e-03	-6.06	cellular homeostasis	biological process	GO:0019725	689	7	18204	49	SLC1A3,SLC4A4,ATP1A2,ATP13A4,RYR3,APOE,ZBTB20
2.328e-03	-6.06	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	31	SLC1A3,SLC1A2
2.341e-03	-6.06	actin filament binding	molecular function	GO:0051015	211	4	18094	48	CTNNA2,ABLIM1,MACF1,NEBL
2.345e-03	-6.06	LRRC7 (leucine rich repeat containing 7)	protein interactions	57554	28	2	19454	50	CTNND2,CAMK2G
2.366e-03	-6.05	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	3	18094	48	SLC1A3,SLC25A18,SLC1A2
2.414e-03	-6.03	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	11	16828	49	NRXN1,COL5A3,MACF1,NEBL,PTPRZ1,CTNND2,CDH20,RYR3,FGFR3,FMN2,PREX2
2.414e-03	-6.03	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	11	16828	49	CTNND2,RYR3,FGFR3,NEBL,COL5A3,NRXN1,PREX2,CDH20,FMN2,PTPRZ1,MACF1
2.467e-03	-6.00	response to alkaloid	biological process	GO:0043279	100	3	18204	49	SLC1A2,SLC1A3,RYR3
2.482e-03	-6.00	monoatomic ion homeostasis	biological process	GO:0050801	515	6	18204	49	ATP1A2,ATP13A4,RYR3,APOE,SLC4A4,SLC1A3
2.564e-03	-5.97	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	49	CLU
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	Sh2b1 (SH2B adaptor protein 1)	protein interactions	20399	1	1	19454	50	FGFR3
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	fgf3.L (fibroblast growth factor 3 L homeolog)	protein interactions	373669	1	1	19454	50	FGFR3
2.570e-03	-5.96	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	50	NRXN1
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.579e-03	-5.96	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	7	16828	49	PREX2,TRPM3,FGFR3,ACSS1,ABLIM1,TNIK,MACF1
2.593e-03	-5.95	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	44	ATP1A2,ATP13A4
2.609e-03	-5.95	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	24	ATP1A2,SLC4A4
2.609e-03	-5.95	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	24	ATP1A2,SLC4A4
2.626e-03	-5.94	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	16	16828	49	PTPRZ1,MACF1,ZNRF3,PREX2,TRPM3,FMN2,SORBS1,COL5A3,NPAS3,CAMK2G,RORA,SPARCL1,CTNND2,RYR3,APOE,FGFR3
2.626e-03	-5.94	embryonal	COSMIC cancer mutations	embryonal	2659	16	16828	49	APOE,RYR3,CTNND2,FGFR3,SPARCL1,RORA,NPAS3,COL5A3,CAMK2G,SORBS1,FMN2,TRPM3,PREX2,MACF1,ZNRF3,PTPRZ1
2.653e-03	-5.93	metal chelating activity	molecular function	GO:0046911	1	1	18094	48	APOE
2.653e-03	-5.93	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	48	NTRK2
2.671e-03	-5.93	human chr20p11.21	chromosome location	human chr20p11.21	40	2	26134	50	ACSS1,CST3
2.673e-03	-5.92	lipoprotein particle receptor binding	molecular function	GO:0070325	29	2	18094	48	CLU,APOE
2.692e-03	-5.92	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	49	CLU
2.692e-03	-5.92	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	49	NRG3
2.692e-03	-5.92	olfactory cortex development	biological process	GO:0021989	1	1	18204	49	ATP1A2
2.692e-03	-5.92	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	49	APOE
2.692e-03	-5.92	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	49	CST3
2.692e-03	-5.92	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	49	FMN2
2.692e-03	-5.92	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	49	APOE
2.692e-03	-5.92	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	49	ATP1A2
2.692e-03	-5.92	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	49	CST3
2.692e-03	-5.92	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	49	APOE
2.692e-03	-5.92	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	49	NTRK2
2.692e-03	-5.92	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	49	APOE
2.692e-03	-5.92	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	49	NTRK2
2.692e-03	-5.92	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	49	CLU
2.692e-03	-5.92	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	49	NRG3
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	ZNRF3_Znf_RING	interpro domains	IPR045903	1	1	18521	50	ZNRF3
2.700e-03	-5.91	M14_CPE_CPD	interpro domains	IPR034232	1	1	18521	50	CPE
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	SLC1A3,SOX5,NEBL,ACSS1,SLC4A4,RORA,CPE,ABLIM1,PTPRZ1,FMN2,BMPR1B,CAMK2G,DTNA,FGFR3,ATP1A2,HIF3A,NRG3,MACF1,CST3,NRXN1,NPAS3,COL5A3,SLC25A18,SORBS1,GPM6A,RYR3,ATP13A4,SFXN5,NKAIN3,PAMR1,SPARCL1,GPC5,ZNRF3,NHSL1,CDH20,SLC1A2,LSAMP,CLU,TNIK,CTNND2,APOE,NTRK2,ZBTB20,RANBP3L,TRPM3,PREX2,NTM,PITPNC1
2.751e-03	-5.90	postsynaptic membrane organization	biological process	GO:0001941	29	2	18204	49	APOE,NRXN1
2.754e-03	-5.89	FGFR3_TM	pfam domains	PF21165	1	1	17795	49	FGFR3
2.774e-03	-5.89	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	6	16828	49	NTRK2,FGFR3,CAMK2G,TNIK,BMPR1B,MACF1
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	SLC1A2,CDH20,ZNRF3,GPC5,NHSL1,GPM6A,RYR3,PAMR1,SPARCL1,NKAIN3,SFXN5,ATP13A4,SLC25A18,COL5A3,NPAS3,NRXN1,SORBS1,TRPM3,NTM,PREX2,PITPNC1,RANBP3L,CTNND2,APOE,NTRK2,ZBTB20,TNIK,LSAMP,CLU,FMN2,ABLIM1,PTPRZ1,RORA,CPE,SLC4A4,SLC1A3,ACSS1,NEBL,SOX5,CST3,MACF1,FGFR3,DTNA,ATP1A2,NRG3,HIF3A,BMPR1B,CAMK2G
2.828e-03	-5.87	chemical homeostasis	biological process	GO:0048878	914	8	18204	49	SLC4A4,SLC1A3,ATP1A2,RYR3,ATP13A4,ZBTB20,APOE,RORA
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CTNNA2,CDH20
2.859e-03	-5.86	inorganic ion transmembrane transport	biological process	GO:0098660	715	7	18204	49	GPM6A,SLC1A3,SLC4A4,TRPM3,RYR3,SLC25A18,ATP1A2
2.870e-03	-5.85	SH2B1 (SH2B adaptor protein 1)	protein interactions	25970	31	2	19454	50	FGFR3,NTRK2
2.919e-03	-5.84	non_seminoma	COSMIC cancer mutations	non_seminoma	492	6	16828	49	TNIK,BMPR1B,CAMK2G,MACF1,FGFR3,NTRK2
2.934e-03	-5.83	extracellular matrix	cellular component	GO:0031012	559	6	19108	49	GPC5,PTPRZ1,COL5A3,SPARCL1,APOE,CLU
2.952e-03	-5.83	cellular response to endogenous stimulus	biological process	GO:0071495	1135	9	18204	49	NTRK2,SLC1A2,SLC1A3,ATP1A2,BMPR1B,RYR3,FGFR3,SOX5,SORBS1
2.960e-03	-5.82	external encapsulating structure	cellular component	GO:0030312	560	6	19108	49	PTPRZ1,GPC5,COL5A3,SPARCL1,APOE,CLU
3.014e-03	-5.80	t(4;14) translocations of FGFR3	REACTOME pathways	R-HSA-2033515	1	1	10285	31	FGFR3
3.041e-03	-5.80	-	gene3d domains	6.10.250.1740	1	1	14470	44	FGFR3
3.055e-03	-5.79	CDH1 (cadherin 1)	protein interactions	999	757	7	19454	50	MACF1,NEBL,CTNNA2,CTNND2,SORBS1,NHSL1,ABLIM1
3.072e-03	-5.79	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	11	16828	49	PTPRZ1,GPC5,MACF1,PREX2,FMN2,SORBS1,NPAS3,NRG3,DTNA,FGFR3,RYR3
3.108e-03	-5.77	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	31	RYR3,ATP1A2,CAMK2G,SORBS1
3.149e-03	-5.76	postsynapse organization	biological process	GO:0099173	109	3	18204	49	APOE,CTNND2,NRXN1
3.210e-03	-5.74	Salivary secretion	KEGG pathways	ko04970	90	3	7161	24	CST3,RYR3,ATP1A2
3.210e-03	-5.74	Salivary secretion	KEGG pathways	hsa04970	90	3	7161	24	ATP1A2,CST3,RYR3
3.219e-03	-5.74	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	4	16828	49	COL5A3,SLC4A4,NTM,ATP13A4
3.224e-03	-5.74	human chr11p13	chromosome location	human chr11p13	44	2	26134	50	PAMR1,SLC1A2
3.249e-03	-5.73	VLDLR (very low density lipoprotein receptor)	protein interactions	7436	33	2	19454	50	CLU,APOE
3.282e-03	-5.72	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	49	ATP13A4,ATP1A2
3.344e-03	-5.70	transepithelial transport	biological process	GO:0070633	32	2	18204	49	SLC1A2,SLC1A3
3.344e-03	-5.70	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	49	BMPR1B,SOX5
3.344e-03	-5.70	positive regulation of ATP metabolic process	biological process	GO:1903580	32	2	18204	49	ZBTB20,SLC4A4
3.401e-03	-5.68	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	5	18521	50	TNIK,NTRK2,FGFR3,BMPR1B,CAMK2G
3.430e-03	-5.68	lentigo_maligna	COSMIC cancer mutations	lentigo_maligna	30	2	16828	49	PREX2,FGFR3
3.430e-03	-5.68	skin-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-malignant_melanoma-acral_lentiginous	30	2	16828	49	PREX2,FGFR3
3.465e-03	-5.67	CEACAM8 (CEA cell adhesion molecule 8)	protein interactions	1088	118	3	19454	50	CPE,CLU,APOE
3.486e-03	-5.66	dendrite development	biological process	GO:0016358	113	3	18204	49	PREX2,CTNND2,CTNNA2
3.495e-03	-5.66	Cation_ATPase	pfam domains	PF13246	32	2	17795	49	ATP13A4,ATP1A2
3.611e-03	-5.62	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	44	CLU
3.611e-03	-5.62	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	44	CLU
3.621e-03	-5.62	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	41	16828	49	ZNRF3,GPC5,NHSL1,PTPRZ1,SLC1A2,FMN2,CDH20,SLC1A3,COL5A3,NPAS3,NRXN1,ACSS1,SOX5,NEBL,SORBS1,RYR3,RORA,PAMR1,CPE,SFXN5,ATP13A4,SLC4A4,CST3,MACF1,RANBP3L,TRPM3,PREX2,NTM,BMPR1B,CAMK2G,TNIK,CLU,LSAMP,MSI2,DTNA,FGFR3,ATP1A2,CTNND2,NRG3,NTRK2,ZBTB20
3.688e-03	-5.60	calcium channel activity	molecular function	GO:0005262	117	3	18094	48	TRPM3,GPM6A,RYR3
3.705e-03	-5.60	DELLA	smart domains	SM01129	1	1	9717	36	MACF1
3.769e-03	-5.58	exploration behavior	biological process	GO:0035640	34	2	18204	49	ATP1A2,APOE
3.772e-03	-5.58	localization	biological process	GO:0051179	4474	21	18204	49	TNIK,NTRK2,RANBP3L,SLC4A4,SLC1A3,NRXN1,PITPNC1,RYR3,ATP13A4,SFXN5,CAMK2G,FMN2,MACF1,CPE,CLU,SLC1A2,GPM6A,SLC25A18,ATP1A2,TRPM3,APOE
3.792e-03	-5.57	PAS-like_dom_sf	interpro domains	IPR035965	34	2	18521	50	NPAS3,HIF3A
3.792e-03	-5.57	PAS	interpro domains	IPR000014	34	2	18521	50	HIF3A,NPAS3
3.795e-03	-5.57	PAS	smart domains	SM00091	25	2	9717	36	HIF3A,NPAS3
3.839e-03	-5.56	plasma lipoprotein particle	cellular component	GO:0034358	36	2	19108	49	CLU,APOE
3.839e-03	-5.56	lipoprotein particle	cellular component	GO:1990777	36	2	19108	49	CLU,APOE
3.857e-03	-5.56	SLC5A5 (solute carrier family 5 member 5)	protein interactions	6528	36	2	19454	50	SFXN5,CAMK2G
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A2,SLC1A3
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	FGFR3,NTM,NTRK2,LSAMP
3.936e-03	-5.54	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	21	16828	49	SORBS1,CLU,COL5A3,NPAS3,SLC1A3,CAMK2G,PAMR1,RORA,SPARCL1,CTNND2,RYR3,APOE,FGFR3,NHSL1,PTPRZ1,MACF1,ZNRF3,PREX2,CDH20,TRPM3,FMN2
3.937e-03	-5.54	synapse assembly	biological process	GO:0007416	118	3	18204	49	NRG3,GPM6A,NRXN1
3.969e-03	-5.53	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	4	19454	50	NHSL1,TNIK,NTRK2,SORBS1
3.978e-03	-5.53	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	5	16828	49	CPE,PREX2,TRPM3,CTNND2,MACF1
4.007e-03	-5.52	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	31	16828	49	GPC5,ABLIM1,NHSL1,PTPRZ1,FMN2,SLC1A2,CDH20,SLC1A3,COL5A3,ACSS1,SOX5,NEBL,GPM6A,RYR3,RORA,PAMR1,CPE,SPARCL1,NKAIN3,ATP13A4,SFXN5,MACF1,RANBP3L,PREX2,BMPR1B,TNIK,LSAMP,CLU,CTNND2,NRG3,NTRK2
4.018e-03	-5.52	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	21	NTRK2
4.071e-03	-5.50	HPCA (hippocalcin)	protein interactions	3208	37	2	19454	50	GPM6A,CST3
4.099e-03	-5.50	proteoglycan binding	molecular function	GO:0043394	36	2	18094	48	APOE,COL5A3
4.127e-03	-5.49	striated muscle contraction	biological process	GO:0006941	120	3	18204	49	DTNA,ATP1A2,RYR3
4.161e-03	-5.48	cytoskeletal protein binding	molecular function	GO:0008092	989	8	18094	48	APOE,CTNNA2,FMN2,NEBL,MACF1,SORBS1,CLU,ABLIM1
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP1A2,ATP13A4
4.258e-03	-5.46	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	3	19454	50	ABLIM1,MACF1,DTNA
4.289e-03	-5.45	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	49	SORBS1,COL5A3,MACF1,SLC4A4,PREX2,ATP13A4,NTM,FGFR3,CTNND2
4.290e-03	-5.45	MMP3 (matrix metallopeptidase 3)	protein interactions	4314	38	2	19454	50	APOE,CLU
4.335e-03	-5.44	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	40	16828	49	NPAS3,NRXN1,COL5A3,SLC1A3,SLC25A18,SOX5,NEBL,SORBS1,ACSS1,GPM6A,RYR3,SFXN5,NKAIN3,ATP13A4,RORA,PAMR1,SPARCL1,CPE,GPC5,ABLIM1,NHSL1,PTPRZ1,CDH20,FMN2,SLC1A2,LSAMP,CLU,TNIK,CAMK2G,CTNND2,FGFR3,DTNA,ATP1A2,NTRK2,ZBTB20,NRG3,MACF1,RANBP3L,TRPM3,PREX2
4.413e-03	-5.42	arm	COSMIC cancer mutations	arm	1331	10	16828	49	MACF1,NPAS3,COL5A3,SORBS1,ATP1A2,FGFR3,TRPM3,SLC4A4,ZBTB20,NTM
4.451e-03	-5.41	positive regulation of nucleotide metabolic process	biological process	GO:0045981	37	2	18204	49	SLC4A4,ZBTB20
4.451e-03	-5.41	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	49	SLC1A2,SORBS1
4.451e-03	-5.41	positive regulation of purine nucleotide metabolic process	biological process	GO:1900544	37	2	18204	49	ZBTB20,SLC4A4
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP1A2,ATP13A4
4.493e-03	-5.41	protein-lipid complex	cellular component	GO:0032994	39	2	19108	49	APOE,CLU
4.506e-03	-5.40	cellular component assembly	biological process	GO:0022607	2472	14	18204	49	NEBL,FMN2,CLU,GPM6A,SLC1A2,CDH20,NRG3,APOE,TRPM3,TNIK,NRXN1,ABLIM1,RYR3,SORBS1
4.523e-03	-5.40	positive regulation of lipid metabolic process	biological process	GO:0045834	124	3	18204	49	ZBTB20,APOE,SORBS1
4.543e-03	-5.39	animal organ morphogenesis	biological process	GO:0009887	988	8	18204	49	FGFR3,SOX5,NRG3,ABLIM1,BMPR1B,CPE,CTNNA2,NTRK2
4.602e-03	-5.38	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	6	19454	50	DTNA,FGFR3,NHSL1,ABLIM1,TNIK,CLU
4.616e-03	-5.38	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	28	16828	49	FMN2,ABLIM1,PTPRZ1,GPC5,ZNRF3,RORA,PAMR1,CPE,ATP13A4,SLC4A4,RYR3,SOX5,NRXN1,NTM,PITPNC1,PREX2,TRPM3,MACF1,NRG3,NTRK2,ZBTB20,FGFR3,ATP1A2,CTNND2,CAMK2G,TNIK,BMPR1B,CLU
4.616e-03	-5.38	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	28	16828	49	MACF1,TRPM3,PREX2,NTM,PITPNC1,CAMK2G,BMPR1B,TNIK,CLU,FGFR3,ATP1A2,CTNND2,NRG3,NTRK2,ZBTB20,GPC5,ZNRF3,ABLIM1,PTPRZ1,FMN2,NRXN1,SOX5,RYR3,PAMR1,RORA,CPE,ATP13A4,SLC4A4
4.668e-03	-5.37	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	377	5	16828	49	TRPM3,FGFR3,COL5A3,NRXN1,MACF1
4.691e-03	-5.36	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	49	SLC1A2,SLC1A3
4.705e-03	-5.36	plasma membrane region	cellular component	GO:0098590	1278	9	19108	49	GPM6A,SLC1A2,SLC1A3,TNIK,NRXN1,SLC4A4,SORBS1,MACF1,ATP1A2
4.744e-03	-5.35	DZIP1 (DAZ interacting zinc finger protein 1)	protein interactions	22873	40	2	19454	50	NTRK2,CAMK2G
4.753e-03	-5.35	endoplasmic reticulum	cellular component	GO:0005783	2051	12	19108	49	CST3,COL5A3,NRXN1,FMN2,ATP1A2,FGFR3,RYR3,SPARCL1,ATP13A4,CAMK2G,APOE,CLU
4.815e-03	-5.34	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	6	16828	49	FGFR3,FMN2,CAMK2G,TNIK,BMPR1B,NTRK2
4.852e-03	-5.33	cellular process	biological process	GO:0009987	14996	47	18204	49	NRG3,SLC25A18,TRPM3,PTPRZ1,CST3,CPE,CLU,CTNNA2,ABLIM1,SORBS1,TNIK,GPC5,DTNA,BMPR1B,MSI2,FMN2,MACF1,FGFR3,SFXN5,RANBP3L,NRXN1,ZBTB20,LSAMP,NHSL1,COL5A3,NEBL,GPM6A,PITPNC1,SLC4A4,CTNND2,ATP1A2,APOE,SPARCL1,SOX5,CAMK2G,HIF3A,ZNRF3,SLC1A2,CDH20,PREX2,RYR3,ATP13A4,RORA,NTRK2,ACSS1,SLC1A3,NTM
4.858e-03	-5.33	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	6	16828	49	CAMK2G,BMPR1B,TNIK,NTRK2,FMN2,FGFR3
4.936e-03	-5.31	positive regulation of nitric oxide biosynthetic process	biological process	GO:0045429	39	2	18204	49	APOE,CLU
4.936e-03	-5.31	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	49	ATP1A2,SLC1A3
4.945e-03	-5.31	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	3	19454	50	CPE,GPM6A,NTM
4.977e-03	-5.30	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	21	16828	49	ZNRF3,MACF1,NHSL1,PTPRZ1,TRPM3,FMN2,CDH20,PREX2,SLC1A3,CAMK2G,COL5A3,CLU,NPAS3,SORBS1,FGFR3,CTNND2,RYR3,APOE,PAMR1,RORA,SPARCL1
5.029e-03	-5.29	chemical synaptic transmission	biological process	GO:0007268	415	5	18204	49	APOE,NRXN1,SLC1A3,DTNA,SLC1A2
5.029e-03	-5.29	anterograde trans-synaptic signaling	biological process	GO:0098916	415	5	18204	49	NRXN1,SLC1A3,DTNA,SLC1A2,APOE
5.042e-03	-5.29	testis	COSMIC cancer mutations	testis	733	7	16828	49	PREX2,NTRK2,FGFR3,BMPR1B,CAMK2G,TNIK,MACF1
5.049e-03	-5.29	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	3	19454	50	ABLIM1,DTNA,NTRK2
5.122e-03	-5.27	chylomicron remnant	cellular component	GO:0034360	2	1	19108	49	APOE
5.122e-03	-5.27	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	49	APOE
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	RYR3,DTNA,MACF1,SPARCL1
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.135e-03	-5.27	prostate	COSMIC cancer mutations	prostate	13883	47	16828	49	ATP1A2,DTNA,FGFR3,NRG3,HIF3A,BMPR1B,MACF1,CPE,RORA,SLC4A4,SLC1A3,ACSS1,SOX5,NEBL,FMN2,PTPRZ1,ABLIM1,APOE,CTNND2,ZBTB20,NTRK2,TNIK,CLU,LSAMP,MSI2,TRPM3,PITPNC1,PREX2,NTM,RANBP3L,RYR3,GPM6A,SPARCL1,PAMR1,ATP13A4,NKAIN3,SFXN5,SLC25A18,COL5A3,NRXN1,NPAS3,SORBS1,SLC1A2,CDH20,ZNRF3,GPC5,NHSL1
5.157e-03	-5.27	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	8	16828	49	BMPR1B,TNIK,CAMK2G,MACF1,FGFR3,ATP1A2,NTRK2,PREX2
5.187e-03	-5.26	positive regulation of nitric oxide metabolic process	biological process	GO:1904407	40	2	18204	49	APOE,CLU
5.198e-03	-5.26	RDX (radixin)	protein interactions	5962	272	4	19454	50	ABLIM1,MACF1,FGFR3,NEBL
5.198e-03	-5.26	PAS	prosite domains	PS50112	30	2	12186	44	HIF3A,NPAS3
5.210e-03	-5.26	fibula	COSMIC cancer mutations	fibula	387	5	16828	49	FGFR3,TRPM3,MACF1,COL5A3,NRXN1
5.251e-03	-5.25	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	3	16828	49	CDH20,DTNA,FGFR3
5.271e-03	-5.25	carboxylic acid transmembrane transport	biological process	GO:1905039	131	3	18204	49	SLC1A3,SLC1A2,SLC25A18
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	44	ATP13A4,ATP1A2
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	44	ATP13A4,ATP1A2
5.376e-03	-5.23	acetate biosynthetic process	biological process	GO:0019413	2	1	18204	49	ACSS1
5.376e-03	-5.23	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	49	CLU
5.376e-03	-5.23	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	49	CST3
5.376e-03	-5.23	fibroblast growth factor receptor apoptotic signaling pathway	biological process	GO:1902178	2	1	18204	49	FGFR3
5.376e-03	-5.23	Wnt receptor catabolic process	biological process	GO:0038018	2	1	18204	49	ZNRF3
5.376e-03	-5.23	acetyl-CoA biosynthetic process from acetate	biological process	GO:0019427	2	1	18204	49	ACSS1
5.376e-03	-5.23	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	49	CST3
5.376e-03	-5.23	propionate biosynthetic process	biological process	GO:0019542	2	1	18204	49	ACSS1
5.376e-03	-5.23	mesenchymal cell differentiation involved in bone development	biological process	GO:1901706	2	1	18204	49	RANBP3L
5.376e-03	-5.23	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	49	APOE
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Ac_CoA_lig	interpro domains	IPR011904	2	1	18521	50	ACSS1
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	ZNRF-3_ecto	interpro domains	IPR040700	2	1	18521	50	ZNRF3
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.440e-03	-5.21	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	2	19108	49	RYR3,CAMK2G
5.493e-03	-5.20	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	3	17795	49	FGFR3,NTRK2,BMPR1B
5.500e-03	-5.20	Clusterin	pfam domains	PF01093	2	1	17795	49	CLU
5.500e-03	-5.20	ZNRF_3_ecto	pfam domains	PF18212	2	1	17795	49	ZNRF3
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A2,SLC1A3
5.547e-03	-5.19	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	50	FGFR3,BMPR1B,NTRK2
5.565e-03	-5.19	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	4	18204	49	ZNRF3,APOE,CTNND2,GPC5
5.612e-03	-5.18	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	48	RYR3,GPM6A,TRPM3
5.706e-03	-5.17	triglyceride homeostasis	biological process	GO:0070328	42	2	18204	49	APOE,RORA
5.729e-03	-5.16	organic acid transmembrane transport	biological process	GO:1903825	135	3	18204	49	SLC1A3,SLC1A2,SLC25A18
5.755e-03	-5.16	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	47	16828	49	APOE,CTNND2,ZBTB20,NTRK2,LSAMP,CLU,TNIK,MSI2,TRPM3,PITPNC1,PREX2,RANBP3L,RYR3,GPM6A,NKAIN3,ATP13A4,SFXN5,SPARCL1,PAMR1,COL5A3,NRXN1,NPAS3,SLC25A18,SORBS1,CDH20,SLC1A2,GPC5,ZNRF3,NHSL1,ATP1A2,DTNA,FGFR3,HIF3A,NRG3,CAMK2G,BMPR1B,MACF1,SLC4A4,CPE,RORA,SLC1A3,NEBL,SOX5,ACSS1,FMN2,PTPRZ1,ABLIM1
5.755e-03	-5.16	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	47	16828	49	NHSL1,ZNRF3,GPC5,SLC1A2,CDH20,SORBS1,SLC25A18,COL5A3,NPAS3,NRXN1,SPARCL1,PAMR1,NKAIN3,ATP13A4,SFXN5,RYR3,GPM6A,RANBP3L,PITPNC1,PREX2,TRPM3,MSI2,TNIK,LSAMP,CLU,ZBTB20,NTRK2,APOE,CTNND2,PTPRZ1,ABLIM1,FMN2,ACSS1,SOX5,NEBL,SLC1A3,CPE,RORA,SLC4A4,MACF1,CAMK2G,BMPR1B,NRG3,HIF3A,ATP1A2,DTNA,FGFR3
5.767e-03	-5.16	sarcolemma	cellular component	GO:0042383	142	3	19108	49	RYR3,DTNA,ATP1A2
5.806e-03	-5.15	tau protein binding	molecular function	GO:0048156	43	2	18094	48	APOE,CLU
5.968e-03	-5.12	small_intestine	COSMIC cancer mutations	small_intestine	250	4	16828	49	TNIK,ZNRF3,FGFR3,MACF1
5.974e-03	-5.12	acylglycerol homeostasis	biological process	GO:0055090	43	2	18204	49	APOE,RORA
6.004e-03	-5.12	inorganic ion homeostasis	biological process	GO:0098771	433	5	18204	49	APOE,SLC1A3,RYR3,ATP13A4,ATP1A2
6.073e-03	-5.10	-	gene3d domains	6.20.350.10	2	1	14470	44	RYR3
6.073e-03	-5.10	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	44	CTNNA2
6.081e-03	-5.10	system process	biological process	GO:0003008	2015	12	18204	49	ATP1A2,APOE,PTPRZ1,SLC1A2,CTNNA2,ABLIM1,RYR3,NTRK2,SLC4A4,SLC1A3,NRXN1,DTNA
6.088e-03	-5.10	regulation of generation of precursor metabolites and energy	biological process	GO:0043467	138	3	18204	49	SORBS1,ZBTB20,SLC4A4
6.224e-03	-5.08	cellular component organization	biological process	GO:0016043	5636	24	18204	49	NEBL,GPM6A,CLU,CTNNA2,COL5A3,CST3,TRPM3,PTPRZ1,NRG3,CTNND2,TNIK,SORBS1,PITPNC1,ABLIM1,FMN2,MACF1,SLC1A2,CDH20,APOE,SPARCL1,BMPR1B,NRXN1,PREX2,RYR3
6.247e-03	-5.08	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	49	SORBS1,SLC1A2
6.272e-03	-5.07	DSCR9 (Down syndrome critical region 9)	protein interactions	257203	146	3	19454	50	CLU,MACF1,SPARCL1
6.281e-03	-5.07	animal organ development	biological process	GO:0048513	2846	15	18204	49	RANBP3L,NTRK2,ABLIM1,FGFR3,RORA,COL5A3,CTNNA2,SLC1A2,GPM6A,NEBL,CPE,ATP1A2,BMPR1B,NRG3,SOX5
6.348e-03	-5.06	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	4	19454	50	FMN2,SORBS1,NEBL,NHSL1
6.391e-03	-5.05	MOB4 (MOB family member 4, phocein)	protein interactions	25843	147	3	19454	50	ABLIM1,CAMK2G,TNIK
6.414e-03	-5.05	telencephalon development	biological process	GO:0021537	276	4	18204	49	ATP1A2,NRG3,NTRK2,SLC1A2
6.429e-03	-5.05	extremity	COSMIC cancer mutations	extremity	1876	12	16828	49	ACSS1,NEBL,PTPRZ1,COL5A3,ATP13A4,PREX2,PITPNC1,NTRK2,FGFR3,FMN2,CDH20,RYR3
6.500e-03	-5.04	BDNF (brain derived neurotrophic factor)	protein interactions	627	47	2	19454	50	CPE,NTRK2
6.500e-03	-5.04	CNTN1 (contactin 1)	protein interactions	1272	47	2	19454	50	PTPRZ1,GPM6A
6.550e-03	-5.03	PAS domain	gene3d domains	3.30.450.20	40	2	14470	44	NPAS3,HIF3A
6.588e-03	-5.02	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	49	SLC1A2,SLC1A3,SLC4A4
6.624e-03	-5.02	metal ion transport	biological process	GO:0030001	630	6	18204	49	SLC1A3,GPM6A,SLC4A4,TRPM3,ATP1A2,RYR3
6.660e-03	-5.01	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	4	16828	49	FMN2,PTPRZ1,SLC4A4,ATP13A4
6.743e-03	-5.00	PFN1 (profilin 1)	protein interactions	5216	466	5	19454	50	CAMK2G,ABLIM1,NHSL1,FMN2,MACF1
6.812e-03	-4.99	receptor clustering	biological process	GO:0043113	46	2	18204	49	APOE,NRXN1
6.875e-03	-4.98	Ig_3	pfam domains	PF13927	141	3	17795	49	LSAMP,FGFR3,NTM
6.881e-03	-4.98	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	3	19454	50	TNIK,CLU,MACF1
6.941e-03	-4.97	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	7	16828	49	TNIK,CAMK2G,BMPR1B,SOX5,FGFR3,CTNND2,NTRK2
6.941e-03	-4.97	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	7	16828	49	CTNND2,FGFR3,NTRK2,CAMK2G,BMPR1B,TNIK,SOX5
7.103e-03	-4.95	regulation of neuron migration	biological process	GO:2001222	47	2	18204	49	NRG3,CTNNA2
7.144e-03	-4.94	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	4	18094	48	SLC4A4,SLC1A3,SLC25A18,SLC1A2
7.209e-03	-4.93	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	44	SPARCL1
7.209e-03	-4.93	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	44	SPARCL1
7.306e-03	-4.92	Statin Pathway	WikiPathways	WP430	33	2	5310	21	APOE,ACSS1
7.396e-03	-4.91	CLa	smart domains	SM00035	2	1	9717	36	CLU
7.396e-03	-4.91	CLb	smart domains	SM00030	2	1	9717	36	CLU
7.404e-03	-4.91	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	4	16828	49	SOX5,RYR3,APOE,CDH20
7.426e-03	-4.90	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	44	ATP1A2,ATP13A4
7.456e-03	-4.90	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	9	16828	49	LSAMP,TNIK,GPC5,RANBP3L,SOX5,CTNND2,NKAIN3,NRG3,RORA
7.519e-03	-4.89	neuromuscular process	biological process	GO:0050905	149	3	18204	49	NRXN1,SLC1A3,CTNNA2
7.592e-03	-4.88	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	49	ZNRF3,MACF1
7.592e-03	-4.88	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	49	ZNRF3,MACF1
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	NHSL1,MACF1
7.688e-03	-4.87	Retinoid metabolism and transport	REACTOME pathways	R-HSA-975634	44	2	10285	31	GPC5,APOE
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	50	NRXN1
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Lrrc7 (leucine rich repeat containing 7)	protein interactions	117284	3	1	19454	50	CAMK2G
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.700e-03	-4.87	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	3	16828	49	GPC5,FGFR3,NRG3
7.720e-03	-4.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	10	16828	49	SLC4A4,CTNND2,RYR3,TRPM3,FMN2,SORBS1,NRXN1,LSAMP,GPC5,TNIK
7.750e-03	-4.86	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	21	16828	49	PREX2,TRPM3,FMN2,ABLIM1,NHSL1,PTPRZ1,RANBP3L,MACF1,ZNRF3,HIF3A,NRG3,GPM6A,CTNND2,RYR3,FGFR3,DTNA,ATP1A2,SOX5,ACSS1,CLU,SLC1A3
7.750e-03	-4.86	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	21	16828	49	TRPM3,FMN2,PREX2,ZNRF3,MACF1,NHSL1,ABLIM1,PTPRZ1,RANBP3L,DTNA,FGFR3,ATP1A2,GPM6A,CTNND2,RYR3,NRG3,HIF3A,SLC1A3,CLU,ACSS1,SOX5
7.847e-03	-4.85	protein localization to membrane	biological process	GO:0072657	462	5	18204	49	NRXN1,MACF1,CPE,APOE,TNIK
7.909e-03	-4.84	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	50	NTRK2,SORBS1
7.928e-03	-4.84	TYRO3 (TYRO3 protein tyrosine kinase)	protein interactions	7301	159	3	19454	50	CLU,SLC1A3,APOE
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.987e-03	-4.83	cellular response to organic cyclic compound	biological process	GO:0071407	464	5	18204	49	ATP1A2,RYR3,SLC1A3,SLC1A2,RORA
8.020e-03	-4.83	FORMIN	prints domains	PR00828	2	1	5227	21	FMN2
8.054e-03	-4.82	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	49	APOE
8.054e-03	-4.82	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	49	FMN2
8.054e-03	-4.82	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	49	FMN2
8.054e-03	-4.82	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	49	CLU
8.054e-03	-4.82	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	49	NTRK2
8.054e-03	-4.82	mammary placode formation	biological process	GO:0060596	3	1	18204	49	NRG3
8.054e-03	-4.82	immune complex clearance	biological process	GO:0002434	3	1	18204	49	CLU
8.054e-03	-4.82	cysteine transport	biological process	GO:0042883	3	1	18204	49	SLC1A2
8.054e-03	-4.82	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	49	NEBL
8.054e-03	-4.82	acetate metabolic process	biological process	GO:0006083	3	1	18204	49	ACSS1
8.054e-03	-4.82	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	49	FMN2
8.054e-03	-4.82	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	49	NRXN1
8.054e-03	-4.82	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	49	SLC1A2
8.054e-03	-4.82	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	49	ATP1A2
8.054e-03	-4.82	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	49	APOE
8.054e-03	-4.82	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	49	CTNNA2
8.061e-03	-4.82	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	5	16828	49	BMPR1B,TNIK,CAMK2G,FGFR3,NTRK2
8.061e-03	-4.82	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	5	16828	49	NTRK2,FGFR3,TNIK,BMPR1B,CAMK2G
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	50	HIF3A
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	DTNA,SORBS1,MACF1,NRXN1
8.172e-03	-4.81	positive regulation of nervous system development	biological process	GO:0051962	296	4	18204	49	PTPRZ1,NRXN1,MACF1,NTRK2
8.230e-03	-4.80	learning	biological process	GO:0007612	154	3	18204	49	NTRK2,ATP1A2,NRXN1
8.238e-03	-4.80	Myelin_PLP	pfam domains	PF01275	3	1	17795	49	GPM6A
8.238e-03	-4.80	Sorb	pfam domains	PF02208	3	1	17795	49	SORBS1
8.238e-03	-4.80	HIF-1	pfam domains	PF11413	3	1	17795	49	HIF3A
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK2
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR3
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR3
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR3
8.238e-03	-4.80	SR_plectin_7	pfam domains	PF21097	3	1	17795	49	MACF1
8.320e-03	-4.79	neuromuscular process controlling balance	biological process	GO:0050885	51	2	18204	49	NRXN1,SLC1A3
8.446e-03	-4.77	CATATPASE	prints domains	PR00119	35	2	5227	21	ATP13A4,ATP1A2
8.525e-03	-4.76	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	49	NTRK2,BMPR1B,GPM6A
8.585e-03	-4.76	regulation of signaling	biological process	GO:0023051	3534	17	18204	49	APOE,BMPR1B,ATP1A2,NRG3,CLU,ZNRF3,MACF1,FGFR3,SORBS1,RORA,PREX2,CTNND2,SLC1A3,NRXN1,GPC5,TNIK,NTRK2
8.613e-03	-4.75	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	20	16828	49	TRPM3,ZNRF3,GPC5,MACF1,PTPRZ1,ATP1A2,DTNA,FGFR3,RYR3,CTNND2,SPARCL1,CPE,HIF3A,ATP13A4,TNIK,LSAMP,COL5A3,NRXN1,ACSS1,SOX5
8.638e-03	-4.75	regulation of purine nucleotide catabolic process	biological process	GO:0033121	52	2	18204	49	ZBTB20,SLC4A4
8.638e-03	-4.75	regulation of nucleotide catabolic process	biological process	GO:0030811	52	2	18204	49	ZBTB20,SLC4A4
8.638e-03	-4.75	regulation of glycolytic process	biological process	GO:0006110	52	2	18204	49	ZBTB20,SLC4A4
8.675e-03	-4.75	positive regulation of synaptic transmission	biological process	GO:0050806	157	3	18204	49	NTRK2,NRXN1,SLC1A3
8.711e-03	-4.74	skin-lentigo	COSMIC cancer mutations	skin-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-forearm-lentigo	COSMIC cancer mutations	skin-forearm-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-leg-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-trunk-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	urinary_tract-bladder-papilloma	COSMIC cancer mutations	urinary_tract-bladder-papilloma	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-lentigo	COSMIC cancer mutations	skin-trunk-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-face-lentigo	COSMIC cancer mutations	skin-face-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-lentigo	COSMIC cancer mutations	skin-leg-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-hand-lentigo	COSMIC cancer mutations	skin-hand-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	lentigo	COSMIC cancer mutations	lentigo	3	1	16828	49	FGFR3
8.712e-03	-4.74	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	48	ATP1A2,ATP13A4
8.730e-03	-4.74	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	31	CAMK2G,ATP1A2,RYR3
8.748e-03	-4.74	ZYX (zyxin)	protein interactions	7791	316	4	19454	50	ABLIM1,SORBS1,NEBL,MACF1
8.758e-03	-4.74	regulation of cell communication	biological process	GO:0010646	3541	17	18204	49	CLU,MACF1,ZNRF3,APOE,BMPR1B,ATP1A2,NRG3,CTNND2,NRXN1,SLC1A3,GPC5,TNIK,NTRK2,FGFR3,SORBS1,RORA,PREX2
8.772e-03	-4.74	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	5	16828	49	BMPR1B,TNIK,CAMK2G,FGFR3,NTRK2
8.814e-03	-4.73	SYN1 (synapsin I)	protein interactions	6853	55	2	19454	50	GPM6A,CAMK2G
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	NEBL,ATP1A2,ABLIM1
8.962e-03	-4.71	regulation of chondrocyte differentiation	biological process	GO:0032330	53	2	18204	49	BMPR1B,SOX5
8.962e-03	-4.71	neutral amino acid transport	biological process	GO:0015804	53	2	18204	49	SLC1A3,SLC1A2
8.979e-03	-4.71	monoatomic anion transport	biological process	GO:0006820	159	3	18204	49	SLC4A4,SLC1A2,SLC1A3
9.053e-03	-4.70	CTNNB1 (catenin beta 1)	protein interactions	1499	926	7	19454	50	APOE,NHSL1,CTNNA2,DTNA,PTPRZ1,SORBS1,CTNND2
9.095e-03	-4.70	-	gene3d domains	6.10.250.2510	3	1	14470	44	CTNNA2
9.095e-03	-4.70	-	gene3d domains	1.10.490.160	3	1	14470	44	RYR3
9.147e-03	-4.69	presynaptic membrane	cellular component	GO:0042734	168	3	19108	49	GPM6A,NRXN1,SLC1A2
9.191e-03	-4.69	EF-hand	gene3d domains	1.10.238.10	272	4	14470	44	SPARCL1,MACF1,DTNA,RYR3
9.290e-03	-4.68	negative regulation of supramolecular fiber organization	biological process	GO:1902904	161	3	18204	49	APOE,CTNNA2,CLU
9.303e-03	-4.68	Prot_kinase_dom	interpro domains	IPR000719	480	5	18521	50	NTRK2,TNIK,CAMK2G,FGFR3,BMPR1B
9.442e-03	-4.66	NXPH3 (neurexophilin 3)	protein interactions	11248	57	2	19454	50	CTNNA2,NRXN1
9.613e-03	-4.64	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	21	SLC1A2,CST3
9.616e-03	-4.64	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	48	16828	49	APOE,CTNND2,ZBTB20,NTRK2,TNIK,LSAMP,CLU,MSI2,TRPM3,PITPNC1,PREX2,NTM,RANBP3L,RYR3,GPM6A,SPARCL1,PAMR1,NKAIN3,ATP13A4,SFXN5,SLC25A18,NRXN1,NPAS3,COL5A3,SORBS1,SLC1A2,CDH20,ZNRF3,GPC5,NHSL1,ATP1A2,DTNA,FGFR3,NRG3,HIF3A,CAMK2G,BMPR1B,MACF1,CPE,RORA,SLC4A4,SLC1A3,ACSS1,SOX5,NEBL,FMN2,PTPRZ1,ABLIM1
9.625e-03	-4.64	intermembrane lipid transfer	biological process	GO:0120009	55	2	18204	49	PITPNC1,APOE
9.625e-03	-4.64	response to cocaine	biological process	GO:0042220	55	2	18204	49	SLC1A3,SLC1A2
9.634e-03	-4.64	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	49	16828	49	NHSL1,GPC5,ZNRF3,CDH20,SLC1A2,SORBS1,NRXN1,NPAS3,COL5A3,SLC25A18,ATP13A4,SFXN5,NKAIN3,PAMR1,SPARCL1,GPM6A,RYR3,RANBP3L,PREX2,PITPNC1,NTM,TRPM3,MSI2,LSAMP,CLU,TNIK,NTRK2,ZBTB20,CTNND2,APOE,ABLIM1,PTPRZ1,FMN2,NEBL,SOX5,ACSS1,SLC1A3,SLC4A4,RORA,CPE,MACF1,CST3,CAMK2G,BMPR1B,HIF3A,NRG3,FGFR3,DTNA,ATP1A2
9.687e-03	-4.64	lipid transfer activity	molecular function	GO:0120013	56	2	18094	48	PITPNC1,APOE
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	ATP1A2,NTRK2,GPM6A
9.763e-03	-4.63	CILK1 (ciliogenesis associated kinase 1)	protein interactions	22858	58	2	19454	50	MSI2,CAMK2G
9.767e-03	-4.63	negative regulation of neuron apoptotic process	biological process	GO:0043524	164	3	18204	49	PTPRZ1,CLU,NTRK2
9.847e-03	-4.62	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	26	16828	49	SLC1A3,COL5A3,NPAS3,SOX5,NEBL,RYR3,SPARCL1,PAMR1,RORA,SLC4A4,NKAIN3,ATP13A4,PTPRZ1,ABLIM1,CAMK2G,ATP1A2,FGFR3,DTNA,CTNND2,NRG3,ZBTB20,NTRK2,CST3,MACF1,TRPM3,PREX2
9.871e-03	-4.62	cell-cell junction	cellular component	GO:0005911	513	5	19108	49	SORBS1,ATP1A2,CTNNA2,CDH20,CTNND2
9.929e-03	-4.61	import across plasma membrane	biological process	GO:0098739	165	3	18204	49	SLC1A2,SLC1A3,ATP1A2
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	ATP1A2,NTRK2,GPM6A
1.009e-02	-4.60	VEGFA (vascular endothelial growth factor A)	protein interactions	7422	59	2	19454	50	PTPRZ1,CLU
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	CTNNA2,CDH20,DTNA
1.022e-02	-4.58	collagen type V trimer	cellular component	GO:0005588	4	1	19108	49	COL5A3
1.022e-02	-4.58	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	49	APOE
1.023e-02	-4.58	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	31	SLC1A2,SLC1A3
1.023e-02	-4.58	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	5	16828	49	BMPR1B,TNIK,CAMK2G,FGFR3,NTRK2
1.024e-02	-4.58	CALML4 (calmodulin like 4)	protein interactions	91860	4	1	19454	50	CAMK2G
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.031e-02	-4.57	visual behavior	biological process	GO:0007632	57	2	18204	49	ATP1A2,SLC1A2
1.032e-02	-4.57	cellular component organization or biogenesis	biological process	GO:0071840	5850	24	18204	49	BMPR1B,APOE,SPARCL1,FMN2,MACF1,SLC1A2,CDH20,PREX2,RYR3,NRXN1,NRG3,TRPM3,PTPRZ1,CST3,COL5A3,NEBL,GPM6A,CLU,CTNNA2,PITPNC1,ABLIM1,SORBS1,TNIK,CTNND2
1.032e-02	-4.57	SLC-mediated transmembrane transport	REACTOME pathways	R-HSA-425407	287	4	10285	31	SLC1A3,SLC1A2,SLC25A18,SLC4A4
1.037e-02	-4.57	cellular component biogenesis	biological process	GO:0044085	2716	14	18204	49	FMN2,NEBL,CDH20,SLC1A2,GPM6A,CLU,TRPM3,APOE,NRG3,NRXN1,TNIK,SORBS1,RYR3,ABLIM1
1.042e-02	-4.56	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	5	16828	49	FGFR3,TNIK,CAMK2G,BMPR1B,NTRK2
1.042e-02	-4.56	ITGA8 (integrin subunit alpha 8)	protein interactions	8516	60	2	19454	50	CLU,ZNRF3
1.042e-02	-4.56	SNTB1 (syntrophin beta 1)	protein interactions	6641	60	2	19454	50	DTNA,FGFR3
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.057e-02	-4.55	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	48	NTRK2
1.057e-02	-4.55	acetate-CoA ligase activity	molecular function	GO:0003987	4	1	18094	48	ACSS1
1.057e-02	-4.55	citrate transmembrane transporter activity	molecular function	GO:0015137	4	1	18094	48	SFXN5
1.057e-02	-4.55	tricarboxylic acid transmembrane transporter activity	molecular function	GO:0015142	4	1	18094	48	SFXN5
1.057e-02	-4.55	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	48	APOE
1.057e-02	-4.55	propionate-CoA ligase activity	molecular function	GO:0050218	4	1	18094	48	ACSS1
1.057e-02	-4.55	short-chain fatty acid-CoA ligase activity	molecular function	GO:0031955	4	1	18094	48	ACSS1
1.061e-02	-4.55	SYNPO (synaptopodin)	protein interactions	11346	177	3	19454	50	ABLIM1,CAMK2G,ZBTB20
1.072e-02	-4.54	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	49	APOE
1.072e-02	-4.54	short-chain fatty acid biosynthetic process	biological process	GO:0051790	4	1	18204	49	ACSS1
1.072e-02	-4.54	malate-aspartate shuttle	biological process	GO:0043490	4	1	18204	49	SLC25A18
1.072e-02	-4.54	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	49	SOX5
1.072e-02	-4.54	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	49	CLU
1.072e-02	-4.54	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	49	APOE
1.072e-02	-4.54	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	49	NTRK2
1.072e-02	-4.54	response to glycoside	biological process	GO:1903416	4	1	18204	49	ATP1A2
1.072e-02	-4.54	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	49	CST3
1.072e-02	-4.54	protein localization to secretory granule	biological process	GO:0033366	4	1	18204	49	CPE
1.072e-02	-4.54	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	49	APOE
1.072e-02	-4.54	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	49	ATP1A2
1.072e-02	-4.54	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	49	ATP1A2
1.072e-02	-4.54	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	49	NTRK2
1.072e-02	-4.54	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	49	BMPR1B
1.072e-02	-4.54	response to caloric restriction	biological process	GO:0061771	4	1	18204	49	APOE
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	ACAS_N	interpro domains	IPR032387	4	1	18521	50	ACSS1
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	FGF_rcpt_fam	interpro domains	IPR016248	4	1	18521	50	FGFR3
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	ApoA_E	interpro domains	IPR000074	4	1	18521	50	APOE
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	Ca/CaM-dep_prot_kinase-assoc	interpro domains	IPR013543	4	1	18521	50	CAMK2G
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.079e-02	-4.53	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	44	GPM6A
1.079e-02	-4.53	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	44	GPM6A
1.079e-02	-4.53	SOHO	prosite domains	PS50831	3	1	12186	44	SORBS1
1.079e-02	-4.53	VINCULIN_1	prosite domains	PS00663	3	1	12186	44	CTNNA2
1.090e-02	-4.52	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	6	16828	49	CAMK2G,BMPR1B,TNIK,PREX2,NTRK2,FGFR3
1.097e-02	-4.51	Spectrin_4	pfam domains	PF21020	4	1	17795	49	MACF1
1.097e-02	-4.51	Nebulin	pfam domains	PF00880	4	1	17795	49	NEBL
1.097e-02	-4.51	Apolipoprotein	pfam domains	PF01442	4	1	17795	49	APOE
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	AbLIM_anchor	pfam domains	PF16182	4	1	17795	49	ABLIM1
1.097e-02	-4.51	Spectrin_2	pfam domains	PF18373	4	1	17795	49	MACF1
1.097e-02	-4.51	TRPM_tetra	pfam domains	PF16519	4	1	17795	49	TRPM3
1.097e-02	-4.51	NHS	pfam domains	PF15273	4	1	17795	49	NHSL1
1.097e-02	-4.51	CaMKII_AD	pfam domains	PF08332	4	1	17795	49	CAMK2G
1.097e-02	-4.51	P5-ATPase	pfam domains	PF12409	4	1	17795	49	ATP13A4
1.097e-02	-4.51	ACAS_N	pfam domains	PF16177	4	1	17795	49	ACSS1
1.097e-02	-4.51	Spectrin_3	pfam domains	PF21019	4	1	17795	49	MACF1
1.098e-02	-4.51	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	5	16828	49	NTRK2,FGFR3,TNIK,BMPR1B,CAMK2G
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	FMN2,PTPRZ1,ABLIM1,CPE,RORA,SLC4A4,SLC1A3,ACSS1,NEBL,SOX5,CST3,MACF1,ATP1A2,DTNA,FGFR3,NRG3,HIF3A,BMPR1B,CAMK2G,SLC1A2,CDH20,GPC5,ZNRF3,NHSL1,RYR3,GPM6A,SPARCL1,PAMR1,NKAIN3,SFXN5,ATP13A4,SLC25A18,COL5A3,NRXN1,NPAS3,SORBS1,TRPM3,PITPNC1,PREX2,NTM,RANBP3L,APOE,CTNND2,ZBTB20,NTRK2,TNIK,CLU,LSAMP,MSI2
1.101e-02	-4.51	Metabolism of fat-soluble vitamins	REACTOME pathways	R-HSA-6806667	53	2	10285	31	APOE,GPC5
1.101e-02	-4.51	endochondral bone morphogenesis	biological process	GO:0060350	59	2	18204	49	BMPR1B,FGFR3
1.107e-02	-4.50	Sorb	smart domains	SM00459	3	1	9717	36	SORBS1
1.107e-02	-4.50	PLP	smart domains	SM00002	3	1	9717	36	GPM6A
1.113e-02	-4.50	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	5	12186	44	CAMK2G,BMPR1B,TNIK,FGFR3,NTRK2
1.113e-02	-4.50	cell migration	biological process	GO:0016477	921	7	18204	49	NTRK2,GPC5,FMN2,CTNNA2,GPM6A,CDH20,NRG3
1.118e-02	-4.49	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	49	PAMR1,MACF1,RYR3,GPC5
1.121e-02	-4.49	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	7	19454	50	FGFR3,MACF1,PITPNC1,SORBS1,CAMK2G,ABLIM1,NHSL1
1.128e-02	-4.48	cartilage development	biological process	GO:0051216	173	3	18204	49	FGFR3,SOX5,BMPR1B
1.134e-02	-4.48	IGc2	smart domains	SM00408	239	4	9717	36	NTRK2,LSAMP,FGFR3,NTM
1.137e-02	-4.48	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	49	NTRK2,ATP1A2
1.137e-02	-4.48	export across plasma membrane	biological process	GO:0140115	60	2	18204	49	SLC4A4,ATP1A2
1.137e-02	-4.48	regulation of glucose import	biological process	GO:0046324	60	2	18204	49	SLC1A2,SORBS1
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.144e-02	-4.47	NLGN2 (neuroligin 2)	protein interactions	57555	63	2	19454	50	CLU,NRXN1
1.148e-02	-4.47	regulation of lipid metabolic process	biological process	GO:0019216	327	4	18204	49	APOE,ZBTB20,RORA,SORBS1
1.153e-02	-4.46	circulatory system process	biological process	GO:0003013	508	5	18204	49	SLC4A4,APOE,SLC1A3,SLC1A2,ATP1A2
1.153e-02	-4.46	response to endogenous stimulus	biological process	GO:0009719	1402	9	18204	49	NTRK2,SLC1A3,SLC1A2,ATP1A2,BMPR1B,RYR3,FGFR3,SOX5,SORBS1
1.160e-02	-4.46	urinary_tract-bladder-papilloma-inverted	COSMIC cancer mutations	urinary_tract-bladder-papilloma-inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-other-normal	COSMIC cancer mutations	urinary_tract-bladder-other-normal	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.160e-02	-4.46	inverted	COSMIC cancer mutations	inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.160e-02	-4.46	skin-benign_melanocytic_nevus-junctional	COSMIC cancer mutations	skin-benign_melanocytic_nevus-junctional	4	1	16828	49	FGFR3
1.171e-02	-4.45	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	40	16828	49	CDH20,FMN2,SLC1A2,PTPRZ1,NHSL1,ABLIM1,GPC5,SLC4A4,NKAIN3,SFXN5,ATP13A4,CPE,SPARCL1,PAMR1,RORA,RYR3,NEBL,SOX5,ACSS1,COL5A3,NPAS3,NRXN1,SLC1A3,PREX2,NTM,TRPM3,RANBP3L,MACF1,HIF3A,NTRK2,NRG3,CTNND2,ATP1A2,DTNA,FGFR3,MSI2,LSAMP,TNIK,BMPR1B,CAMK2G
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	NTRK2,FGFR3
1.182e-02	-4.44	central nervous system neuron differentiation	biological process	GO:0021953	176	3	18204	49	RORA,NTRK2,BMPR1B
1.184e-02	-4.44	cadherin binding	molecular function	GO:0045296	335	4	18094	48	CTNNA2,CDH20,MACF1,CTNND2
1.201e-02	-4.42	RORNUCRECPTR	prints domains	PR01293	3	1	5227	21	RORA
1.201e-02	-4.42	NTKRECEPTOR	prints domains	PR01939	3	1	5227	21	NTRK2
1.201e-02	-4.42	RYANODINER	prints domains	PR00795	3	1	5227	21	RYR3
1.201e-02	-4.42	MYELINPLP	prints domains	PR00214	3	1	5227	21	GPM6A
1.205e-02	-4.42	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	20	19454	50	ACSS1,CST3,NTM,CTNNA2,TNIK,CLU,GPM6A,PITPNC1,MACF1,ATP1A2,SLC1A3,DTNA,CTNND2,APOE,LSAMP,SLC4A4,CAMK2G,PTPRZ1,SLC25A18,MSI2
1.211e-02	-4.41	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	44	TRPM3
1.211e-02	-4.41	-	gene3d domains	1.20.58.1060	4	1	14470	44	MACF1
1.211e-02	-4.41	regulation of carbohydrate catabolic process	biological process	GO:0043470	62	2	18204	49	SLC4A4,ZBTB20
1.216e-02	-4.41	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	49	RYR3,MACF1,GPM6A,GPC5,PAMR1
1.219e-02	-4.41	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	9	16828	49	SORBS1,NPAS3,MACF1,COL5A3,ZBTB20,SLC4A4,NTM,ATP1A2,TRPM3
1.221e-02	-4.41	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	7	16828	49	FGFR3,PREX2,NTRK2,MACF1,CAMK2G,TNIK,BMPR1B
1.228e-02	-4.40	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	6	16828	49	FGFR3,TNIK,CAMK2G,BMPR1B,NTRK2,SPARCL1
1.237e-02	-4.39	lipid homeostasis	biological process	GO:0055088	179	3	18204	49	RORA,APOE,ZBTB20
1.249e-02	-4.38	regulation of nitric oxide biosynthetic process	biological process	GO:0045428	63	2	18204	49	APOE,CLU
1.249e-02	-4.38	back	COSMIC cancer mutations	back	310	4	16828	49	PREX2,FGFR3,ATP1A2,TNIK
1.262e-02	-4.37	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	6	16828	49	FGFR3,NTRK2,SPARCL1,CAMK2G,TNIK,BMPR1B
1.265e-02	-4.37	brain development	biological process	GO:0007420	724	6	18204	49	RORA,NRG3,ATP1A2,SLC1A2,CTNNA2,NTRK2
1.276e-02	-4.36	calcium- and calmodulin-dependent protein kinase complex	cellular component	GO:0005954	5	1	19108	49	CAMK2G
1.276e-02	-4.36	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	49	CLU
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	CAMK2N2 (calcium/calmodulin dependent protein kinase II inhibitor 2)	protein interactions	94032	5	1	19454	50	CAMK2G
1.279e-02	-4.36	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	50	NRXN1
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	TRH (thyrotropin releasing hormone)	protein interactions	7200	5	1	19454	50	CPE
1.287e-02	-4.35	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	49	SORBS1,FMN2
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	NHSL1,GPC5,ZNRF3,SLC1A2,CDH20,SORBS1,SLC25A18,COL5A3,NPAS3,NRXN1,PAMR1,SPARCL1,SFXN5,NKAIN3,ATP13A4,GPM6A,RYR3,RANBP3L,PREX2,NTM,PITPNC1,TRPM3,MSI2,TNIK,LSAMP,CLU,NTRK2,ZBTB20,CTNND2,APOE,ABLIM1,PTPRZ1,FMN2,ACSS1,NEBL,SOX5,SLC1A3,RORA,CPE,SLC4A4,CST3,MACF1,CAMK2G,BMPR1B,NRG3,HIF3A,FGFR3,ATP1A2
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	SORBS1,NEBL
1.313e-02	-4.33	Kinase-like_dom_sf	interpro domains	IPR011009	523	5	18521	50	TNIK,NTRK2,CAMK2G,FGFR3,BMPR1B
1.320e-02	-4.33	neuroligin family protein binding	molecular function	GO:0097109	5	1	18094	48	NRXN1
1.320e-02	-4.33	fibroblast growth factor receptor activity	molecular function	GO:0005007	5	1	18094	48	FGFR3
1.320e-02	-4.33	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	48	NTRK2
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.323e-02	-4.33	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	4	19454	50	TNIK,SORBS1,NEBL,MACF1
1.325e-02	-4.32	positive regulation of synapse assembly	biological process	GO:0051965	65	2	18204	49	NTRK2,NRXN1
1.325e-02	-4.32	regulation of nitric oxide metabolic process	biological process	GO:0080164	65	2	18204	49	CLU,APOE
1.328e-02	-4.32	signal transduction	biological process	GO:0007165	4637	20	18204	49	APOE,SPARCL1,NRG3,ATP1A2,BMPR1B,ZNRF3,FMN2,MACF1,CPE,CLU,RORA,SORBS1,FGFR3,PITPNC1,PREX2,RYR3,DTNA,CTNND2,NTRK2,TNIK
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.339e-02	-4.31	tricarboxylic acid transport	biological process	GO:0006842	5	1	18204	49	SFXN5
1.339e-02	-4.31	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	49	APOE
1.339e-02	-4.31	amygdala development	biological process	GO:0021764	5	1	18204	49	ATP1A2
1.339e-02	-4.31	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	49	APOE
1.339e-02	-4.31	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	49	CLU
1.339e-02	-4.31	citrate transport	biological process	GO:0015746	5	1	18204	49	SFXN5
1.339e-02	-4.31	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	49	NRXN1
1.339e-02	-4.31	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	49	NTRK2
1.339e-02	-4.31	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	49	APOE
1.339e-02	-4.31	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	49	FMN2
1.339e-02	-4.31	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	49	APOE
1.339e-02	-4.31	propionate metabolic process	biological process	GO:0019541	5	1	18204	49	ACSS1
1.339e-02	-4.31	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	49	BMPR1B
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	Mtc	interpro domains	IPR004686	5	1	18521	50	SFXN5
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	RANBP3L,NTM,PREX2,TRPM3,MSI2,LSAMP,CLU,TNIK,NTRK2,ZBTB20,CTNND2,APOE,NHSL1,GPC5,ZNRF3,CDH20,SLC1A2,SORBS1,NRXN1,COL5A3,NPAS3,SLC25A18,ATP13A4,NKAIN3,SFXN5,PAMR1,SPARCL1,GPM6A,RYR3,MACF1,CST3,CAMK2G,BMPR1B,HIF3A,NRG3,FGFR3,DTNA,ATP1A2,ABLIM1,PTPRZ1,FMN2,NEBL,SOX5,ACSS1,SLC1A3,SLC4A4,RORA,CPE
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.369e-02	-4.29	FOLN	pfam domains	PF09289	5	1	17795	49	SPARCL1
1.369e-02	-4.29	SFXNs	pfam domains	PF03820	5	1	17795	49	SFXN5
1.369e-02	-4.29	Vinculin	pfam domains	PF01044	5	1	17795	49	CTNNA2
1.404e-02	-4.27	cholesterol transport	biological process	GO:0030301	67	2	18204	49	APOE,CLU
1.404e-02	-4.27	collagen binding	molecular function	GO:0005518	68	2	18094	48	SPARCL1,COL5A3
1.410e-02	-4.26	signal release	biological process	GO:0023061	188	3	18204	49	NRXN1,CPE,CAMK2G
1.412e-02	-4.26	membrane protein complex	cellular component	GO:0098796	1261	8	19108	49	SLC1A3,SLC1A2,RYR3,CDH20,BMPR1B,CTNNA2,ATP1A2,SORBS1
1.424e-02	-4.25	EGF	pfam domains	PF00008	66	2	17795	49	NRXN1,PAMR1
1.429e-02	-4.25	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	12	16828	49	PREX2,NTRK2,SLC4A4,FGFR3,DTNA,ATP1A2,SOX5,PTPRZ1,TNIK,CAMK2G,BMPR1B,SLC25A18
1.430e-02	-4.25	regulation of lipid biosynthetic process	biological process	GO:0046890	189	3	18204	49	APOE,ZBTB20,SORBS1
1.437e-02	-4.24	NEBULIN	prosite domains	PS51216	4	1	12186	44	NEBL
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	GPM6A,TNIK
1.444e-02	-4.24	actin filament bundle organization	biological process	GO:0061572	68	2	18204	49	FMN2,SORBS1
1.448e-02	-4.24	skin-shoulder-other-nevus_sebaceous	COSMIC cancer mutations	skin-shoulder-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-nevus_sebaceous	COSMIC cancer mutations	skin-face-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_arm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_arm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-lichenoid_keratosis	COSMIC cancer mutations	skin-breast-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-ear-other-nevus_sebaceous	COSMIC cancer mutations	skin-ear-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-scalp-other-nevus_sebaceous	COSMIC cancer mutations	skin-scalp-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-nevus_sebaceous	COSMIC cancer mutations	skin-neck-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-forearm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	syringocystadenoma_papilliferum	COSMIC cancer mutations	syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-lichenoid_keratosis	COSMIC cancer mutations	skin-face-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hip-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-hip-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-forearm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-adnexal_tumour-syringocystadenoma_papilliferum	COSMIC cancer mutations	skin-adnexal_tumour-syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-nevus_sebaceous	COSMIC cancer mutations	skin-lower_back-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-nevus_sebaceous	COSMIC cancer mutations	skin-breast-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-lichenoid_keratosis	COSMIC cancer mutations	skin-neck-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	lichenoid_keratosis	COSMIC cancer mutations	lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-arm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-arm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.448e-02	-4.24	skin-other-lichenoid_keratosis	COSMIC cancer mutations	skin-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-lichenoid_keratosis	COSMIC cancer mutations	skin-shoulder-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-flank-other-lichenoid_keratosis	COSMIC cancer mutations	skin-flank-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hand-other-lichenoid_keratosis	COSMIC cancer mutations	skin-hand-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-chest-other-lichenoid_keratosis	COSMIC cancer mutations	skin-chest-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.451e-02	-4.23	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	50	NTRK2,CLU,TNIK,ABLIM1
1.457e-02	-4.23	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	8	16828	49	GPC5,SOX5,CDH20,RYR3,FMN2,SLC1A2,ATP13A4,NRG3
1.474e-02	-4.22	NEBU	smart domains	SM00227	4	1	9717	36	NEBL
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	TNIK,GPM6A
1.488e-02	-4.21	human chr19q13.32	chromosome location	human chr19q13.32	97	2	26134	50	HIF3A,APOE
1.493e-02	-4.20	presynapse	cellular component	GO:0098793	569	5	19108	49	TNIK,SLC1A2,NRXN1,GPM6A,NTRK2
1.498e-02	-4.20	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	31	NTRK2
1.501e-02	-4.20	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	5	16828	49	NTRK2,BMPR1B,CAMK2G,TNIK,FGFR3
1.511e-02	-4.19	-	gene3d domains	6.10.140.620	5	1	14470	44	CAMK2G
1.511e-02	-4.19	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	44	APOE
1.529e-02	-4.18	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	49	APOE
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	50	NRXN1
1.532e-02	-4.18	FGF18 (fibroblast growth factor 18)	protein interactions	8817	6	1	19454	50	FGFR3
1.532e-02	-4.18	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	50	APOE
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	FGF23 (fibroblast growth factor 23)	protein interactions	8074	6	1	19454	50	FGFR3
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	50	APOE
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	RSPO3 (R-spondin 3)	protein interactions	84870	6	1	19454	50	ZNRF3
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	FGF6 (fibroblast growth factor 6)	protein interactions	2251	6	1	19454	50	FGFR3
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	CIBAR2 (CBY1 interacting BAR domain containing 2)	protein interactions	339145	6	1	19454	50	CAMK2G
1.535e-02	-4.18	cell-cell adhesion	biological process	GO:0098609	546	5	18204	49	CTNNA2,NRXN1,CDH20,SPARCL1,CTNND2
1.549e-02	-4.17	seminoma	COSMIC cancer mutations	seminoma	700	6	16828	49	CAMK2G,BMPR1B,TNIK,FGFR3,PREX2,NTRK2
1.550e-02	-4.17	LIM	pfam domains	PF00412	69	2	17795	49	NEBL,ABLIM1
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	ABLIM1,NRXN1,DTNA
1.554e-02	-4.16	bone development	biological process	GO:0060348	195	3	18204	49	FGFR3,BMPR1B,RANBP3L
1.567e-02	-4.16	peptide hormone secretion	biological process	GO:0030072	71	2	18204	49	CPE,CAMK2G
1.568e-02	-4.16	localization within membrane	biological process	GO:0051668	549	5	18204	49	NRXN1,APOE,CPE,MACF1,TNIK
1.573e-02	-4.15	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	5	16828	49	BMPR1B,TNIK,CAMK2G,FGFR3,NTRK2
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	ABLIM1,NEBL
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.581e-02	-4.15	amino acid:proton symporter activity	molecular function	GO:0005280	6	1	18094	48	SLC25A18
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.581e-02	-4.15	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	48	APOE
1.597e-02	-4.14	locomotory behavior	biological process	GO:0007626	197	3	18204	49	PREX2,ATP1A2,APOE
1.598e-02	-4.14	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	5	14470	44	FGFR3,NTRK2,BMPR1B,TNIK,CAMK2G
1.598e-02	-4.14	ALPHACATENIN	prints domains	PR00805	4	1	5227	21	CTNNA2
1.599e-02	-4.14	regulation of protein catabolic process	biological process	GO:0042176	361	4	18204	49	APOE,FMN2,CLU,CST3
1.599e-02	-4.14	positive regulation of cell projection organization	biological process	GO:0031346	361	4	18204	49	GPM6A,MACF1,APOE,NTRK2
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	HIF3A,NRG3,FGFR3,DTNA,ATP1A2,BMPR1B,CAMK2G,MACF1,CST3,SLC4A4,RORA,CPE,NEBL,SOX5,ACSS1,SLC1A3,FMN2,ABLIM1,PTPRZ1,NTRK2,ZBTB20,CTNND2,APOE,MSI2,LSAMP,CLU,TNIK,NTM,PREX2,TRPM3,RANBP3L,ATP13A4,NKAIN3,SFXN5,PAMR1,SPARCL1,GPM6A,RYR3,SORBS1,NRXN1,NPAS3,COL5A3,SLC25A18,CDH20,SLC1A2,NHSL1,GPC5,ZNRF3
1.604e-02	-4.13	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	1	18204	49	NRXN1
1.604e-02	-4.13	mammary gland formation	biological process	GO:0060592	6	1	18204	49	NRG3
1.604e-02	-4.13	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	49	SLC1A3
1.604e-02	-4.13	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	49	FMN2
1.604e-02	-4.13	vocal learning	biological process	GO:0042297	6	1	18204	49	NRXN1
1.604e-02	-4.13	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	49	APOE
1.604e-02	-4.13	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	49	APOE
1.604e-02	-4.13	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	49	NRG3
1.604e-02	-4.13	imitative learning	biological process	GO:0098596	6	1	18204	49	NRXN1
1.604e-02	-4.13	fused antrum stage	biological process	GO:0048165	6	1	18204	49	BMPR1B
1.604e-02	-4.13	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	49	CST3
1.604e-02	-4.13	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	49	CLU
1.604e-02	-4.13	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	49	SOX5
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	1	18521	50	NRXN1
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	regulation of ATP metabolic process	biological process	GO:1903578	72	2	18204	49	SLC4A4,ZBTB20
1.616e-02	-4.13	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	3	16828	49	GPC5,RYR3,NRG3
1.625e-02	-4.12	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	31	NRG3,FGFR3
1.627e-02	-4.12	sarcoplasmic reticulum	cellular component	GO:0016529	76	2	19108	49	RYR3,CAMK2G
1.633e-02	-4.11	BCL2L1 (BCL2 like 1)	protein interactions	598	208	3	19454	50	RYR3,CLU,ABLIM1
1.640e-02	-4.11	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	3	18204	49	FGFR3,APOE,NTRK2
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	RYR3
1.641e-02	-4.11	Plectin	pfam domains	PF00681	6	1	17795	49	MACF1
1.641e-02	-4.11	Syndecan	pfam domains	PF01034	6	1	17795	49	NRXN1
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	RYR3
1.641e-02	-4.11	EF-hand_2	pfam domains	PF09068	6	1	17795	49	DTNA
1.641e-02	-4.11	GAS2	pfam domains	PF02187	6	1	17795	49	MACF1
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.641e-02	-4.11	SH3_10	pfam domains	PF17902	6	1	17795	49	MACF1
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	RYR3
1.641e-02	-4.11	EF-hand_3	pfam domains	PF09069	6	1	17795	49	DTNA
1.652e-02	-4.10	regulation of cartilage development	biological process	GO:0061035	73	2	18204	49	SOX5,BMPR1B
1.652e-02	-4.10	peptide metabolic process	biological process	GO:0006518	73	2	18204	49	CPE,SLC1A2
1.660e-02	-4.10	atypical	COSMIC cancer mutations	atypical	515	5	16828	49	TNIK,BMPR1B,CAMK2G,FGFR3,NTRK2
1.673e-02	-4.09	axonogenesis	biological process	GO:0007409	366	4	18204	49	BMPR1B,NRXN1,CTNNA2,PTPRZ1
1.675e-02	-4.09	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	50	SLC1A3,NHSL1,SORBS1
1.695e-02	-4.08	sterol transport	biological process	GO:0015918	74	2	18204	49	CLU,APOE
1.696e-02	-4.08	CDK6 (cyclin dependent kinase 6)	protein interactions	1021	211	3	19454	50	FGFR3,SORBS1,SOX5
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP1A2,ATP13A4
1.706e-02	-4.07	intracellular calcium ion homeostasis	biological process	GO:0006874	202	3	18204	49	APOE,RYR3,ATP13A4
1.709e-02	-4.07	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	11	16828	49	FMN2,RYR3,CDH20,NTRK2,ATP13A4,PITPNC1,PREX2,COL5A3,ACSS1,PTPRZ1,NEBL
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.710e-02	-4.07	head development	biological process	GO:0060322	774	6	18204	49	RORA,NRG3,ATP1A2,CTNNA2,SLC1A2,NTRK2
1.717e-02	-4.06	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	50	CLU,APOE
1.717e-02	-4.06	IFIT3 (interferon induced protein with tetratricopeptide repeats 3)	protein interactions	3437	78	2	19454	50	ATP1A2,APOE
1.717e-02	-4.06	Nedd4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	25489	78	2	19454	50	BMPR1B,NTRK2
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-adnexal_tumour-trichoblastoma	COSMIC cancer mutations	skin-adnexal_tumour-trichoblastoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-epidermal_nevus	COSMIC cancer mutations	skin-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	lentiginous_nevus	COSMIC cancer mutations	lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.735e-02	-4.05	skin-benign_melanocytic_nevus-lentiginous_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus-lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-Bowen_disease	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-Bowen_disease	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-face-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-face-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_leg-epidermal_nevus	COSMIC cancer mutations	skin-lower_leg-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	kidney-carcinoma-collecting_duct_carcinoma	COSMIC cancer mutations	kidney-carcinoma-collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-arm-epidermal_nevus	COSMIC cancer mutations	skin-arm-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-upper_leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-upper_leg-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-flank-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-flank-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-epidermal_nevus	COSMIC cancer mutations	skin-head_neck-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-actinic_keratosis	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-actinic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-abdomen-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-abdomen-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-trunk-epidermal_nevus	COSMIC cancer mutations	skin-trunk-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-lower_back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	collecting_duct_carcinoma	COSMIC cancer mutations	collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.738e-02	-4.05	peptide secretion	biological process	GO:0002790	75	2	18204	49	CPE,CAMK2G
1.754e-02	-4.04	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	21	SLC1A3,ATP1A2
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	NHSL1,TNIK,NTRK2
1.765e-02	-4.04	cytoskeleton organization	biological process	GO:0007010	1251	8	18204	49	TNIK,CTNNA2,NEBL,MACF1,FMN2,ABLIM1,APOE,SORBS1
1.769e-02	-4.03	bone-tibia-chondrosarcoma	COSMIC cancer mutations	bone-tibia-chondrosarcoma	70	2	16828	49	RANBP3L,CPE
1.769e-02	-4.03	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	10	16828	49	TRPM3,ZBTB20,HIF3A,MACF1,COL5A3,NPAS3,GPC5,PTPRZ1,SOX5,NEBL
1.774e-02	-4.03	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	49	RYR3,TRPM3,GPM6A
1.782e-02	-4.03	regulation of axon extension	biological process	GO:0030516	76	2	18204	49	MACF1,APOE
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	FGF5 (fibroblast growth factor 5)	protein interactions	2250	7	1	19454	50	FGFR3
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.795e-02	-4.02	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	31	NTRK2
1.795e-02	-4.02	protein kinase activity	molecular function	GO:0004672	577	5	18094	48	BMPR1B,FGFR3,TNIK,CAMK2G,NTRK2
1.801e-02	-4.02	MAP2 (microtubule associated protein 2)	protein interactions	4133	80	2	19454	50	APOE,GPM6A
1.811e-02	-4.01	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	44	MACF1
1.811e-02	-4.01	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	44	MACF1
1.811e-02	-4.01	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	44	RYR3
1.821e-02	-4.01	SMAD binding	molecular function	GO:0046332	78	2	18094	48	BMPR1B,RANBP3L
1.826e-02	-4.00	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	3	19454	50	NKAIN3,ABLIM1,RORA
1.827e-02	-4.00	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	49	NTRK2,MACF1
1.827e-02	-4.00	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	2	18204	49	ATP1A2,NRXN1
1.827e-02	-4.00	neural retina development	biological process	GO:0003407	77	2	18204	49	GPM6A,NTRK2
1.836e-02	-4.00	plasma membrane protein complex	cellular component	GO:0098797	600	5	19108	49	CDH20,BMPR1B,ATP1A2,CTNNA2,SORBS1
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	calcium-dependent protein serine/threonine phosphatase activity	molecular function	GO:0004723	7	1	18094	48	CAMK2G
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.869e-02	-3.98	observational learning	biological process	GO:0098597	7	1	18204	49	NRXN1
1.869e-02	-3.98	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	49	RYR3
1.869e-02	-3.98	negative regulation of non-canonical Wnt signaling pathway	biological process	GO:2000051	7	1	18204	49	ZNRF3
1.869e-02	-3.98	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	49	APOE
1.869e-02	-3.98	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	49	FMN2
1.869e-02	-3.98	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	49	APOE
1.869e-02	-3.98	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	49	PTPRZ1
1.869e-02	-3.98	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	49	APOE
1.869e-02	-3.98	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	49	NRG3
1.869e-02	-3.98	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	49	CLU
1.869e-02	-3.98	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	49	FMN2
1.869e-02	-3.98	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	49	CTNNA2
1.872e-02	-3.98	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	49	SORBS1,SLC1A2
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP13A4,ATP1A2
1.884e-02	-3.97	extracellular region	cellular component	GO:0005576	4350	18	19108	49	COL5A3,PTPRZ1,CST3,GPM6A,ATP1A2,PAMR1,TNIK,SLC4A4,NRG3,LSAMP,GPC5,FGFR3,APOE,NTM,CLU,SPARCL1,CPE,NEBL
1.889e-02	-3.97	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	47	16828	49	RANBP3L,TRPM3,NTM,PREX2,PITPNC1,LSAMP,CLU,TNIK,MSI2,CTNND2,NTRK2,ZBTB20,ZNRF3,GPC5,NHSL1,CDH20,SLC1A2,NPAS3,COL5A3,NRXN1,SLC25A18,SORBS1,GPM6A,RYR3,NKAIN3,ATP13A4,SFXN5,PAMR1,SPARCL1,MACF1,CAMK2G,BMPR1B,FGFR3,DTNA,ATP1A2,HIF3A,NRG3,ABLIM1,PTPRZ1,FMN2,SLC1A3,SOX5,NEBL,ACSS1,SLC4A4,RORA,CPE
1.912e-02	-3.96	TGF_beta_GS	pfam domains	PF08515	7	1	17795	49	BMPR1B
1.912e-02	-3.96	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	49	SPARCL1
1.914e-02	-3.96	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	49	FGFR3,MACF1
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	ATP1A2,SORBS1
1.925e-02	-3.95	RHOB (ras homolog family member B)	protein interactions	388	832	6	19454	50	MACF1,FMN2,DTNA,TNIK,SLC1A3,ABLIM1
1.929e-02	-3.95	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	15	16828	49	BMPR1B,NPAS3,NEBL,MSI2,FGFR3,ATP1A2,SPARCL1,NRG3,NTRK2,SLC4A4,HIF3A,MACF1,TRPM3,FMN2,NTM
1.929e-02	-3.95	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	15	16828	49	NPAS3,BMPR1B,NEBL,MSI2,FGFR3,ATP1A2,NTRK2,SLC4A4,HIF3A,NRG3,SPARCL1,MACF1,TRPM3,FMN2,NTM
1.930e-02	-3.95	SYT1 (synaptotagmin 1)	protein interactions	6857	83	2	19454	50	NRXN1,GPM6A
1.930e-02	-3.95	DNM3 (dynamin 3)	protein interactions	26052	83	2	19454	50	GPM6A,FGFR3
1.932e-02	-3.95	positive regulation of cell communication	biological process	GO:0010647	1792	10	18204	49	BMPR1B,SORBS1,APOE,FGFR3,NTRK2,TNIK,GPC5,MACF1,NRXN1,SLC1A3
1.939e-02	-3.94	PSEN1 (presenilin 1)	protein interactions	5663	222	3	19454	50	APOE,CTNND2,DTNA
1.943e-02	-3.94	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	TRPM3,SLC1A2,FMN2,PREX2,ATP13A4,MACF1,GPC5
1.943e-02	-3.94	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	MACF1,GPC5,PREX2,ATP13A4,TRPM3,SLC1A2,FMN2
1.946e-02	-3.94	positive regulation of signaling	biological process	GO:0023056	1794	10	18204	49	TNIK,NTRK2,GPC5,MACF1,SLC1A3,NRXN1,BMPR1B,APOE,SORBS1,FGFR3
1.962e-02	-3.93	Axon guidance	KEGG pathways	hsa04360	174	3	7161	24	CAMK2G,ABLIM1,BMPR1B
1.962e-02	-3.93	Axon guidance	KEGG pathways	ko04360	174	3	7161	24	CAMK2G,BMPR1B,ABLIM1
1.964e-02	-3.93	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	49	FGFR3,MACF1
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	NTRK2,FGFR3
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	ABLIM1,GPM6A,MACF1
1.989e-02	-3.92	Neuronal System	REACTOME pathways	R-HSA-112316	349	4	10285	31	NRXN1,SLC1A2,SLC1A3,CAMK2G
1.993e-02	-3.92	PITRANSFER	prints domains	PR00391	5	1	5227	21	PITPNC1
1.993e-02	-3.92	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	21	SLC4A4
2.002e-02	-3.91	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	7	19454	50	MACF1,PITPNC1,FMN2,CAMK2G,ABLIM1,NHSL1,SORBS1
2.009e-02	-3.91	adult locomotory behavior	biological process	GO:0008344	81	2	18204	49	PREX2,ATP1A2
2.021e-02	-3.90	skin-neck-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-neck-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-adnexal_tumour-trichilemmoma	COSMIC cancer mutations	skin-adnexal_tumour-trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-other-nevus_sebaceous	COSMIC cancer mutations	skin-other-nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-intradermal	COSMIC cancer mutations	skin-benign_melanocytic_nevus-intradermal	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-face-adnexal_tumour-malignant_adnexal_tumour	7	1	16828	49	FGFR3
2.021e-02	-3.90	trichilemmoma	COSMIC cancer mutations	trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-compound	COSMIC cancer mutations	skin-benign_melanocytic_nevus-compound	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-shoulder-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-shoulder-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	nevus_sebaceous	COSMIC cancer mutations	nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	urinary_tract-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma-transitional_cell_carcinoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-chest-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-chest-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.032e-02	-3.90	Ethanol Degradation	SMPDB pathways	SMP0000449	7	1	1369	4	ACSS1
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.034e-02	-3.90	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	49	CLU
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	CCK (cholecystokinin)	protein interactions	885	8	1	19454	50	CPE
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.043e-02	-3.89	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	6	16828	49	MACF1,FGFR3,CDH20,NRG3,PREX2,ATP13A4
2.059e-02	-3.88	positive regulation of cellular catabolic process	biological process	GO:0031331	217	3	18204	49	APOE,ZBTB20,SLC4A4
2.059e-02	-3.88	regulation of cell junction assembly	biological process	GO:1901888	217	3	18204	49	NTRK2,NRXN1,MACF1
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	GPM6A,SORBS1
2.063e-02	-3.88	EGLN1 (egl-9 family hypoxia inducible factor 1)	protein interactions	54583	86	2	19454	50	FGFR3,HIF3A
2.072e-02	-3.88	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	44	NEBL,ABLIM1
2.091e-02	-3.87	FGFR3b ligand binding and activation	REACTOME pathways	R-HSA-190371	7	1	10285	31	FGFR3
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	MACF1,SPARCL1,RYR3
2.103e-02	-3.86	peptide transport	biological process	GO:0015833	83	2	18204	49	CAMK2G,CPE
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.109e-02	-3.86	glial cell differentiation	biological process	GO:0010001	219	3	18204	49	NTRK2,PTPRZ1,CLU
2.115e-02	-3.86	supramolecular fiber organization	biological process	GO:0097435	593	5	18204	49	NEBL,SORBS1,FMN2,CST3,COL5A3
2.125e-02	-3.85	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	44	ATP1A2,ATP13A4
2.125e-02	-3.85	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	12	16828	49	SOX5,TNIK,SLC25A18,CAMK2G,BMPR1B,SLC4A4,NTRK2,ATP1A2,FGFR3,DTNA,PTPRZ1,PREX2
2.126e-02	-3.85	skin-leg-malignant_melanoma	COSMIC cancer mutations	skin-leg-malignant_melanoma	549	5	16828	49	ZBTB20,PTPRZ1,HIF3A,NEBL,NRG3
2.127e-02	-3.85	ConA-like_dom_sf	interpro domains	IPR013320	219	3	18521	50	NRXN1,RYR3,COL5A3
2.127e-02	-3.85	DST (dystonin)	protein interactions	667	230	3	19454	50	TNIK,ATP1A2,NTRK2
2.134e-02	-3.85	insulin processing	biological process	GO:0030070	8	1	18204	49	CPE
2.134e-02	-3.85	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	49	FMN2
2.134e-02	-3.85	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	49	CTNNA2
2.134e-02	-3.85	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	49	APOE
2.134e-02	-3.85	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	49	RORA
2.134e-02	-3.85	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	49	ATP1A2
2.134e-02	-3.85	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	49	APOE
2.134e-02	-3.85	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	49	APOE
2.134e-02	-3.85	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	49	RORA
2.134e-02	-3.85	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	49	APOE
2.134e-02	-3.85	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	49	SLC1A3
2.134e-02	-3.85	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	49	RORA
2.134e-02	-3.85	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	49	NRG3
2.134e-02	-3.85	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	49	ATP1A2,SLC1A3,NRXN1
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.147e-02	-3.84	GAR	prosite domains	PS51460	6	1	12186	44	MACF1
2.147e-02	-3.84	GLYPICAN	prosite domains	PS01207	6	1	12186	44	GPC5
2.151e-02	-3.84	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	49	NKAIN3,ATP1A2
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	TNIK,BMPR1B
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	FGFR3,NTM,LSAMP,NTRK2
2.175e-02	-3.83	CTSB (cathepsin B)	protein interactions	1508	232	3	19454	50	APOE,CST3,MSI2
2.182e-02	-3.82	LSDAT_euk	pfam domains	PF18139	8	1	17795	49	TRPM3
2.182e-02	-3.82	VHP	pfam domains	PF02209	8	1	17795	49	ABLIM1
2.203e-02	-3.82	GAS2	smart domains	SM00243	6	1	9717	36	MACF1
2.203e-02	-3.82	SH3_domain	interpro domains	IPR001452	222	3	18521	50	MACF1,SORBS1,NEBL
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	FMN2,DTNA
2.246e-02	-3.80	FGFR1OP2 (FGFR1 oncogene partner 2)	protein interactions	26127	90	2	19454	50	CAMK2G,TNIK
2.249e-02	-3.79	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	3	19454	50	DTNA,NTRK2,MACF1
2.262e-02	-3.79	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	7	16828	49	NRG3,RORA,NKAIN3,CTNND2,SOX5,GPC5,LSAMP
2.268e-02	-3.79	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	6	16828	49	CAMK2G,BMPR1B,TNIK,CDH20,FGFR3,NTRK2
2.268e-02	-3.79	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	6	16828	49	NTRK2,FGFR3,CDH20,CAMK2G,TNIK,BMPR1B
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	50	APOE
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	FGFR3
2.290e-02	-3.78	CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1)	protein interactions	55450	9	1	19454	50	CAMK2G
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	GUSBP1 (GUSB pseudogene 1)	protein interactions	728411	9	1	19454	50	FGFR3
2.290e-02	-3.78	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	50	APOE
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	SORBS1,TNIK
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	GPM6A,NTM
2.293e-02	-3.78	cytoplasmic vesicle	cellular component	GO:0031410	2521	12	19108	49	CAMK2G,CPE,NTRK2,ATP13A4,CLU,ATP1A2,APOE,FGFR3,CST3,FMN2,TNIK,SLC1A3
2.299e-02	-3.77	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	3	19454	50	GPM6A,CAMK2G,SOX5
2.306e-02	-3.77	actinic_keratosis	COSMIC cancer mutations	actinic_keratosis	8	1	16828	49	FGFR3
2.306e-02	-3.77	trichoblastoma	COSMIC cancer mutations	trichoblastoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	junctional	COSMIC cancer mutations	junctional	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.306e-02	-3.77	cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	8	1	16828	49	FGFR3
2.309e-02	-3.77	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	5	16828	49	TNIK,CAMK2G,FGFR3,RYR3,NTRK2
2.320e-02	-3.76	Bile Acid Indirect Signalling Pathway	SMPDB pathways	SMP0086851	8	1	1369	4	FGFR3
2.324e-02	-3.76	Bile secretion	KEGG pathways	ko04976	71	2	7161	24	ATP1A2,SLC4A4
2.324e-02	-3.76	Bile secretion	KEGG pathways	hsa04976	71	2	7161	24	SLC4A4,ATP1A2
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	CLU,SPARCL1,MACF1
2.325e-02	-3.76	forearm	COSMIC cancer mutations	forearm	81	2	16828	49	PREX2,FGFR3
2.332e-02	-3.76	intracellular vesicle	cellular component	GO:0097708	2527	12	19108	49	ATP1A2,NTRK2,SLC1A3,FMN2,CST3,APOE,CLU,ATP13A4,CAMK2G,CPE,TNIK,FGFR3
2.339e-02	-3.76	FNTA (farnesyltransferase, CAAX box, subunit alpha)	protein interactions	2339	92	2	19454	50	FGFR3,TNIK
2.339e-02	-3.76	POTEI (POTE ankyrin domain family member I)	protein interactions	653269	92	2	19454	50	FGFR3,DTNA
2.341e-02	-3.75	skeletal system morphogenesis	biological process	GO:0048705	228	3	18204	49	FGFR3,SOX5,BMPR1B
2.363e-02	-3.75	L-aspartate transmembrane transporter activity	molecular function	GO:0015183	9	1	18094	48	SLC25A18
2.384e-02	-3.74	DISC1 (DISC1 scaffold protein)	protein interactions	27185	427	4	19454	50	SPARCL1,MACF1,TNIK,CLU
2.385e-02	-3.74	forebrain development	biological process	GO:0030900	408	4	18204	49	SLC1A2,ATP1A2,NRG3,NTRK2
2.386e-02	-3.74	Adherens junction	KEGG pathways	hsa04520	72	2	7161	24	CTNNA2,SORBS1
2.386e-02	-3.74	Adherens junction	KEGG pathways	ko04520	72	2	7161	24	SORBS1,CTNNA2
2.387e-02	-3.74	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	31	GPC5
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	ABLIM1,BMPR1B
2.388e-02	-3.73	ACTIVIN2R	prints domains	PR00653	6	1	5227	21	BMPR1B
2.388e-02	-3.73	hand	COSMIC cancer mutations	hand	566	5	16828	49	SLC4A4,HIF3A,PREX2,COL5A3,FGFR3
2.397e-02	-3.73	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	49	APOE
2.397e-02	-3.73	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	49	NRXN1
2.397e-02	-3.73	macrophage proliferation	biological process	GO:0061517	9	1	18204	49	CLU
2.397e-02	-3.73	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	49	CTNNA2
2.397e-02	-3.73	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	49	ATP13A4
2.397e-02	-3.73	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	49	CTNNA2
2.397e-02	-3.73	sterol catabolic process	biological process	GO:0016127	9	1	18204	49	APOE
2.397e-02	-3.73	microglial cell proliferation	biological process	GO:0061518	9	1	18204	49	CLU
2.397e-02	-3.73	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	49	RYR3
2.397e-02	-3.73	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	49	ATP1A2
2.404e-02	-3.73	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	50	CST3
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.407e-02	-3.73	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	44	ABLIM1
2.408e-02	-3.73	ion binding	molecular function	GO:0043167	6007	23	18094	48	SPARCL1,NRXN1,PAMR1,CAMK2G,NTRK2,PITPNC1,ACSS1,RORA,ZNRF3,ATP1A2,BMPR1B,SLC1A2,APOE,SLC1A3,ABLIM1,DTNA,TNIK,FGFR3,ZBTB20,ATP13A4,CPE,MACF1,RYR3
2.411e-02	-3.73	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	49	FGFR3,APOE,PREX2,ATP1A2,RYR3,TNIK
2.420e-02	-3.72	ACTG1 (actin gamma 1)	protein interactions	71	429	4	19454	50	TNIK,ABLIM1,APOE,FMN2
2.422e-02	-3.72	calcium ion homeostasis	biological process	GO:0055074	231	3	18204	49	RYR3,ATP13A4,APOE
2.430e-02	-3.72	protein binding	molecular function	GO:0005515	13983	43	18094	48	GPM6A,NPAS3,MSI2,NRXN1,ZNRF3,ATP1A2,SLC1A2,BMPR1B,PTPRZ1,ACSS1,CTNND2,FGFR3,CDH20,SOX5,ABLIM1,LSAMP,FMN2,CST3,HIF3A,SORBS1,MACF1,SLC25A18,SPARCL1,CLU,SFXN5,RORA,SLC1A3,APOE,NTM,NTRK2,SLC4A4,CAMK2G,PITPNC1,NRG3,TNIK,DTNA,CTNNA2,GPC5,RANBP3L,CPE,COL5A3,NEBL,RYR3
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	TNIK,ABLIM1
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CTNND2,CLU
2.438e-02	-3.71	postsynapse	cellular component	GO:0098794	646	5	19108	49	CTNND2,ATP1A2,TNIK,NTRK2,GPM6A
2.446e-02	-3.71	regulation of purine nucleotide metabolic process	biological process	GO:1900542	90	2	18204	49	ZBTB20,SLC4A4
2.449e-02	-3.71	connective tissue development	biological process	GO:0061448	232	3	18204	49	BMPR1B,SOX5,FGFR3
2.452e-02	-3.71	Band_3_cyto	pfam domains	PF07565	9	1	17795	49	SLC4A4
2.452e-02	-3.71	Activin_recp	pfam domains	PF01064	9	1	17795	49	BMPR1B
2.469e-02	-3.70	neck	COSMIC cancer mutations	neck	1231	8	16828	49	GPC5,COL5A3,FGFR3,TRPM3,ATP1A2,CTNND2,PREX2,ATP13A4
2.470e-02	-3.70	EGF-like_dom	interpro domains	IPR000742	232	3	18521	50	PAMR1,NRXN1,NRG3
2.470e-02	-3.70	positive regulation of signal transduction	biological process	GO:0009967	1593	9	18204	49	MACF1,NRXN1,NTRK2,TNIK,GPC5,SORBS1,APOE,FGFR3,BMPR1B
2.476e-02	-3.70	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	21	NTRK2,SLC1A3,RORA
2.483e-02	-3.70	STRIP1 (striatin interacting protein 1)	protein interactions	85369	95	2	19454	50	TNIK,CAMK2G
2.484e-02	-3.70	vesicle	cellular component	GO:0031982	4141	17	19108	49	ATP1A2,NTRK2,SLC1A3,FMN2,NRXN1,CST3,GPM6A,APOE,CLU,ATP13A4,NEBL,CPE,CAMK2G,SLC1A2,TNIK,SLC4A4,FGFR3
2.495e-02	-3.69	axon	cellular component	GO:0030424	650	5	19108	49	GPM6A,NTRK2,DTNA,SLC1A2,CTNNA2
2.496e-02	-3.69	regulation of nucleotide metabolic process	biological process	GO:0006140	91	2	18204	49	ZBTB20,SLC4A4
2.501e-02	-3.69	GS	prosite domains	PS51256	7	1	12186	44	BMPR1B
2.504e-02	-3.69	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	4	16828	49	NTRK2,FGFR3,TNIK,CAMK2G
2.504e-02	-3.69	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	CAMK2G,TNIK,FGFR3,NTRK2
2.504e-02	-3.69	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	FGFR3,CAMK2G,TNIK,NTRK2
2.504e-02	-3.69	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	NTRK2,FGFR3,CAMK2G,TNIK
2.504e-02	-3.69	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	4	16828	49	NTRK2,TNIK,CAMK2G,FGFR3
2.521e-02	-3.68	sarcoplasm	cellular component	GO:0016528	96	2	19108	49	CAMK2G,RYR3
2.523e-02	-3.68	cation binding	molecular function	GO:0043169	4341	18	18094	48	NRXN1,SPARCL1,PAMR1,ACSS1,SLC1A2,APOE,SLC1A3,BMPR1B,ATP1A2,ZNRF3,RORA,DTNA,ABLIM1,ATP13A4,ZBTB20,RYR3,MACF1,CPE
2.536e-02	-3.67	perineuronal net	cellular component	GO:0072534	10	1	19108	49	PTPRZ1
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	SERPINB11 (serpin family B member 11)	protein interactions	89778	10	1	19454	50	CPE
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.547e-02	-3.67	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	7	19454	50	APOE,PITPNC1,MACF1,ABLIM1,CAMK2G,NHSL1,SORBS1
2.548e-02	-3.67	protein tetramerization	biological process	GO:0051262	92	2	18204	49	RYR3,TRPM3
2.548e-02	-3.67	hormone secretion	biological process	GO:0046879	92	2	18204	49	CPE,CAMK2G
2.566e-02	-3.66	PLEC	smart domains	SM00250	7	1	9717	36	MACF1
2.566e-02	-3.66	GS	smart domains	SM00467	7	1	9717	36	BMPR1B
2.566e-02	-3.66	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	12	16828	49	CTNND2,ATP1A2,SLC1A2,FMN2,TRPM3,ZBTB20,NTRK2,NRG3,ZNRF3,PTPRZ1,SOX5,NHSL1
2.574e-02	-3.66	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	24	ATP1A2,CAMK2G
2.574e-02	-3.66	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	24	ATP1A2,CAMK2G
2.581e-02	-3.66	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	2	19454	50	SPARCL1,CLU
2.586e-02	-3.66	parotid	COSMIC cancer mutations	parotid	578	5	16828	49	NTRK2,FGFR3,CAMK2G,TNIK,RYR3
2.589e-02	-3.65	shoulder	COSMIC cancer mutations	shoulder	387	4	16828	49	MACF1,FGFR3,PREX2,CPE
2.591e-02	-3.65	skin-benign_melanocytic_nevus-congenital	COSMIC cancer mutations	skin-benign_melanocytic_nevus-congenital	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	Bowen_disease	COSMIC cancer mutations	Bowen_disease	9	1	16828	49	FGFR3
2.591e-02	-3.65	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	COSMIC cancer mutations	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	compound	COSMIC cancer mutations	compound	9	1	16828	49	FGFR3
2.591e-02	-3.65	epidermal_nevus	COSMIC cancer mutations	epidermal_nevus	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-other-seborrhoeic_keratosis	9	1	16828	49	FGFR3
2.591e-02	-3.65	in_situ_epithelial_neoplasm	COSMIC cancer mutations	in_situ_epithelial_neoplasm	9	1	16828	49	FGFR3
2.599e-02	-3.65	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	49	BMPR1B,NRG3,NTRK2,FGFR3,SORBS1
2.599e-02	-3.65	regulation of extent of cell growth	biological process	GO:0061387	93	2	18204	49	APOE,MACF1
2.616e-02	-3.64	muscle contraction	biological process	GO:0006936	238	3	18204	49	DTNA,RYR3,ATP1A2
2.618e-02	-3.64	secretion by cell	biological process	GO:0032940	420	4	18204	49	NRXN1,CPE,NTRK2,CAMK2G
2.618e-02	-3.64	axon development	biological process	GO:0061564	420	4	18204	49	CTNNA2,NRXN1,PTPRZ1,BMPR1B
2.621e-02	-3.64	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	44	16828	49	ZBTB20,NTRK2,CTNND2,TNIK,LSAMP,CLU,PREX2,NTM,TRPM3,RANBP3L,SPARCL1,PAMR1,SFXN5,NKAIN3,ATP13A4,RYR3,GPM6A,SORBS1,SLC25A18,COL5A3,NPAS3,NRXN1,SLC1A2,CDH20,NHSL1,GPC5,ZNRF3,NRG3,HIF3A,ATP1A2,FGFR3,BMPR1B,CAMK2G,CST3,MACF1,CPE,RORA,SLC4A4,ACSS1,SOX5,NEBL,SLC1A3,FMN2,PTPRZ1
2.622e-02	-3.64	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	48	ATP13A4
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.622e-02	-3.64	neurotrophin binding	molecular function	GO:0043121	10	1	18094	48	NTRK2
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	LSAMP,GPM6A
2.646e-02	-3.63	human chr2p13.2	chromosome location	human chr2p13.2	14	1	26134	50	SFXN5
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.651e-02	-3.63	mitochondrial transmembrane transport	biological process	GO:1990542	94	2	18204	49	SLC25A18,SFXN5
2.660e-02	-3.63	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	49	APOE
2.660e-02	-3.63	retinal rod cell development	biological process	GO:0046548	10	1	18204	49	NTRK2
2.660e-02	-3.63	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	49	NRG3
2.660e-02	-3.63	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	49	APOE
2.660e-02	-3.63	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	49	NTRK2
2.660e-02	-3.63	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	49	APOE
2.660e-02	-3.63	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	49	APOE
2.660e-02	-3.63	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	1	18204	49	NRXN1
2.660e-02	-3.63	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	49	NRXN1
2.660e-02	-3.63	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	49	NRG3
2.660e-02	-3.63	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	49	APOE
2.660e-02	-3.63	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	49	APOE
2.660e-02	-3.63	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	49	NTRK2
2.660e-02	-3.63	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	49	SOX5
2.660e-02	-3.63	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	49	RYR3
2.660e-02	-3.63	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	49	NRXN1
2.666e-02	-3.62	TGFBR1 (transforming growth factor beta receptor 1)	protein interactions	7046	251	3	19454	50	BMPR1B,CLU,PREX2
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.668e-02	-3.62	Endochondral Ossification	WikiPathways	WP474	65	2	5310	21	SOX5,FGFR3
2.678e-02	-3.62	HSP90AA1 (heat shock protein 90 alpha family class A member 1)	protein interactions	3320	1150	7	19454	50	CLU,ZBTB20,CAMK2G,APOE,HIF3A,NTRK2,FGFR3
2.681e-02	-3.62	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	31	CLU
2.683e-02	-3.62	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	48	ATP1A2,ATP13A4
2.697e-02	-3.61	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	3	10285	31	SLC1A3,CAMK2G,SLC1A2
2.701e-02	-3.61	anchoring junction	cellular component	GO:0070161	902	6	19108	49	CTNNA2,ATP1A2,CDH20,SORBS1,CTNND2,FGFR3
2.702e-02	-3.61	cell motility	biological process	GO:0048870	1101	7	18204	49	GPC5,NTRK2,CDH20,GPM6A,CTNNA2,FMN2,NRG3
2.705e-02	-3.61	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	44	ABLIM1,NEBL
2.705e-02	-3.61	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	44	ABLIM1,NEBL
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	NTRK2,FGFR3
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.720e-02	-3.60	HCO3_cotransp	pfam domains	PF00955	10	1	17795	49	SLC4A4
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	RYR3
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	ATP1A2,GPM6A
2.731e-02	-3.60	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	50	NRXN1,ABLIM1
2.780e-02	-3.58	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	49	NRG3,NTRK2,SORBS1,FGFR3
2.781e-02	-3.58	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	50	CTNNA2,FGFR3
2.783e-02	-3.58	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	4	10285	31	NTRK2,NRG3,CAMK2G,FGFR3
2.786e-02	-3.58	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	49	PTPRZ1
2.788e-02	-3.58	regulation of neuron apoptotic process	biological process	GO:0043523	244	3	18204	49	NTRK2,PTPRZ1,CLU
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	NTS (neurotensin)	protein interactions	4922	11	1	19454	50	CPE
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.792e-02	-3.58	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	50	NRXN1
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	CCDC17 (coiled-coil domain containing 17)	protein interactions	149483	11	1	19454	50	FGFR3
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.806e-02	-3.57	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	31	FGFR3,NRG3
2.826e-02	-3.57	LIM	smart domains	SM00132	71	2	9717	36	NEBL,ABLIM1
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.842e-02	-3.56	SFN (stratifin)	protein interactions	2810	671	5	19454	50	TNIK,ABLIM1,MACF1,SORBS1,FMN2
2.847e-02	-3.56	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	49	PTPRZ1,MACF1,NTRK2
2.851e-02	-3.56	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	5	12186	44	BMPR1B,CAMK2G,TNIK,FGFR3,NTRK2
2.853e-02	-3.56	HP	prosite domains	PS51089	8	1	12186	44	ABLIM1
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.875e-02	-3.55	renal_cell_carcinoma_unclassified	COSMIC cancer mutations	renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	lung-carcinoma-pleomorphic_carcinoma	COSMIC cancer mutations	lung-carcinoma-pleomorphic_carcinoma	10	1	16828	49	FGFR3
2.875e-02	-3.55	kidney-carcinoma-renal_cell_carcinoma_unclassified	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	intradermal	COSMIC cancer mutations	intradermal	10	1	16828	49	FGFR3
2.875e-02	-3.55	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.880e-02	-3.55	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	48	NRXN1
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	GPM6A,BMPR1B
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	NTRK2,LSAMP,NTM,FGFR3
2.917e-02	-3.53	bone morphogenesis	biological process	GO:0060349	99	2	18204	49	BMPR1B,FGFR3
2.917e-02	-3.53	phospholipid transport	biological process	GO:0015914	99	2	18204	49	PITPNC1,APOE
2.922e-02	-3.53	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	49	APOE
2.922e-02	-3.53	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	49	ATP1A2
2.922e-02	-3.53	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	49	BMPR1B
2.922e-02	-3.53	cellular response to caffeine	biological process	GO:0071313	11	1	18204	49	RYR3
2.922e-02	-3.53	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	49	NRG3
2.922e-02	-3.53	regulation of fear response	biological process	GO:1903365	11	1	18204	49	APOE
2.922e-02	-3.53	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	49	ATP1A2
2.922e-02	-3.53	polyamine transport	biological process	GO:0015846	11	1	18204	49	ATP13A4
2.922e-02	-3.53	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	49	APOE
2.922e-02	-3.53	lactone metabolic process	biological process	GO:1901334	11	1	18204	49	ATP1A2
2.922e-02	-3.53	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	49	NRG3
2.922e-02	-3.53	ectodermal placode formation	biological process	GO:0060788	11	1	18204	49	NRG3
2.922e-02	-3.53	glutamate secretion	biological process	GO:0014047	11	1	18204	49	NTRK2
2.927e-02	-3.53	VHP	smart domains	SM00153	8	1	9717	36	ABLIM1
2.927e-02	-3.53	blood vessel morphogenesis	biological process	GO:0048514	435	4	18204	49	HIF3A,NTRK2,APOE,RORA
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.931e-02	-3.53	Fib_collagen_C	interpro domains	IPR000885	11	1	18521	50	COL5A3
2.931e-02	-3.53	Ran_bind_dom	interpro domains	IPR000156	11	1	18521	50	RANBP3L
2.931e-02	-3.53	RanBP1-like	interpro domains	IPR045255	11	1	18521	50	RANBP3L
2.934e-02	-3.53	nervous system process	biological process	GO:0050877	1376	8	18204	49	ATP1A2,ABLIM1,APOE,PTPRZ1,NTRK2,SLC1A3,CTNNA2,NRXN1
2.946e-02	-3.52	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	3	19454	50	FMN2,DTNA,MACF1
2.975e-02	-3.52	amide binding	molecular function	GO:0033218	254	3	18094	48	APOE,CST3,CLU
2.975e-02	-3.51	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	31	SLC4A4
2.975e-02	-3.51	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	31	NRG3
2.975e-02	-3.51	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	31	FGFR3
2.975e-02	-3.51	Organic anion transporters	REACTOME pathways	R-HSA-428643	10	1	10285	31	SLC25A18
2.988e-02	-3.51	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	31	FGFR3,NRG3
2.988e-02	-3.51	Ran_BP1	pfam domains	PF00638	11	1	17795	49	RANBP3L
2.988e-02	-3.51	COLFI	pfam domains	PF01410	11	1	17795	49	COL5A3
2.988e-02	-3.51	PAS_11	pfam domains	PF14598	11	1	17795	49	HIF3A
2.997e-02	-3.51	calcium ion transport	biological process	GO:0006816	251	3	18204	49	RYR3,TRPM3,GPM6A
3.000e-02	-3.51	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	44	SLC4A4
3.010e-02	-3.50	SH3 Domains	gene3d domains	2.30.30.40	223	3	14470	44	NEBL,MACF1,SORBS1
3.027e-02	-3.50	cholesterol homeostasis	biological process	GO:0042632	101	2	18204	49	APOE,RORA
3.027e-02	-3.50	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	49	RORA,SORBS1
3.030e-02	-3.50	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	49	FGFR3,FMN2,CTNND2,PREX2,RANBP3L
3.035e-02	-3.49	positive regulation of developmental process	biological process	GO:0051094	1385	8	18204	49	BMPR1B,PTPRZ1,SOX5,APOE,RANBP3L,NTRK2,NRXN1,MACF1
3.035e-02	-3.49	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	49	PTPRZ1
3.035e-02	-3.49	fibrillar collagen trimer	cellular component	GO:0005583	12	1	19108	49	COL5A3
3.035e-02	-3.49	banded collagen fibril	cellular component	GO:0098643	12	1	19108	49	COL5A3
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.039e-02	-3.49	skin-hand-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-hand-carcinoma-squamous_cell_carcinoma	407	4	16828	49	SLC4A4,HIF3A,COL5A3,FGFR3
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	LGR5 (leucine rich repeat containing G protein-coupled receptor 5)	protein interactions	8549	12	1	19454	50	ZNRF3
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	PROK2 (prokineticin 2)	protein interactions	60675	12	1	19454	50	CPE
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.063e-02	-3.49	spleen	COSMIC cancer mutations	spleen	408	4	16828	49	NTM,PTPRZ1,SORBS1,TNIK
3.067e-02	-3.48	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	2	12186	44	CPE,APOE
3.082e-02	-3.48	sterol homeostasis	biological process	GO:0055092	102	2	18204	49	RORA,APOE
3.083e-02	-3.48	response to stimulus	biological process	GO:0050896	7803	28	18204	49	PREX2,RYR3,FGFR3,RORA,NTRK2,SLC1A3,NRXN1,ATP1A2,BMPR1B,SPARCL1,SOX5,APOE,SLC1A2,MACF1,FMN2,ZNRF3,PITPNC1,SORBS1,TNIK,DTNA,CTNND2,NRG3,ZBTB20,CST3,GPM6A,CTNNA2,CLU,CPE
3.095e-02	-3.48	peptide binding	molecular function	GO:0042277	258	3	18094	48	APOE,CST3,CLU
3.111e-02	-3.47	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	31	NTM,LSAMP
3.114e-02	-3.47	Laminin	gene3d domains	2.10.25.10	226	3	14470	44	NRXN1,NRG3,PAMR1
3.138e-02	-3.46	hormone transport	biological process	GO:0009914	103	2	18204	49	CAMK2G,CPE
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	MSI2,RYR3
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	CLU,GPM6A
3.151e-02	-3.46	VCL (vinculin)	protein interactions	7414	268	3	19454	50	MACF1,NEBL,SORBS1
3.151e-02	-3.46	protein complex oligomerization	biological process	GO:0051259	256	3	18204	49	RYR3,SLC1A2,TRPM3
3.155e-02	-3.46	regulation of multicellular organismal process	biological process	GO:0051239	3113	14	18204	49	NTRK2,NRXN1,SFXN5,RORA,CST3,CAMK2G,CLU,MACF1,BMPR1B,ATP1A2,PTPRZ1,SOX5,ZBTB20,APOE
3.158e-02	-3.46	skin-scalp-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.158e-02	-3.46	pleomorphic_carcinoma	COSMIC cancer mutations	pleomorphic_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	prostate-hyperplasia	COSMIC cancer mutations	prostate-hyperplasia	11	1	16828	49	FGFR3
3.158e-02	-3.46	congenital	COSMIC cancer mutations	congenital	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-neck-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-neck-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	seborrhoeic_keratosis	COSMIC cancer mutations	seborrhoeic_keratosis	11	1	16828	49	FGFR3
3.158e-02	-3.46	kidney-other-oncocytoma	COSMIC cancer mutations	kidney-other-oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	oncocytoma	COSMIC cancer mutations	oncocytoma	11	1	16828	49	FGFR3
3.163e-02	-3.45	regulation of signal transduction	biological process	GO:0009966	3114	14	18204	49	GPC5,NTRK2,TNIK,NRXN1,CTNND2,PREX2,FGFR3,RORA,SORBS1,CLU,ZNRF3,MACF1,BMPR1B,APOE
3.179e-02	-3.45	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	4	RORA
3.184e-02	-3.45	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	49	SLC1A2
3.184e-02	-3.45	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	49	CST3
3.184e-02	-3.45	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	49	BMPR1B
3.184e-02	-3.45	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	49	CST3
3.184e-02	-3.45	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	49	APOE
3.184e-02	-3.45	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	49	BMPR1B
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.193e-02	-3.44	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	37	16828	49	TRPM3,NTM,PREX2,MACF1,RANBP3L,CTNND2,ATP1A2,NTRK2,HIF3A,NRG3,LSAMP,TNIK,CAMK2G,MSI2,CDH20,FMN2,SLC1A2,GPC5,ABLIM1,NHSL1,PTPRZ1,RYR3,ATP13A4,NKAIN3,SFXN5,SLC4A4,RORA,PAMR1,SPARCL1,CPE,NPAS3,COL5A3,NRXN1,SLC1A3,SOX5,NEBL,ACSS1
3.193e-02	-3.44	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	37	16828	49	MSI2,LSAMP,TNIK,CAMK2G,HIF3A,NTRK2,NRG3,CTNND2,ATP1A2,RANBP3L,MACF1,PREX2,NTM,TRPM3,NEBL,SOX5,ACSS1,COL5A3,NRXN1,NPAS3,SLC1A3,SLC4A4,SFXN5,NKAIN3,ATP13A4,CPE,SPARCL1,RORA,PAMR1,RYR3,PTPRZ1,ABLIM1,NHSL1,GPC5,CDH20,FMN2,SLC1A2
3.194e-02	-3.44	regulation of steroid metabolic process	biological process	GO:0019218	104	2	18204	49	APOE,RORA
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	TRPM3,SOX5
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.204e-02	-3.44	CYSTATIN	prosite domains	PS00287	9	1	12186	44	CST3
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	BMPR1B,CAMK2G,ATP1A2,FGFR3,DTNA,NRG3,HIF3A,CST3,MACF1,SLC1A3,ACSS1,NEBL,SOX5,CPE,RORA,SLC4A4,PTPRZ1,ABLIM1,FMN2,TNIK,LSAMP,CLU,MSI2,APOE,CTNND2,ZBTB20,NTRK2,RANBP3L,TRPM3,PITPNC1,NTM,PREX2,SLC25A18,NRXN1,NPAS3,COL5A3,SORBS1,RYR3,GPM6A,SPARCL1,PAMR1,SFXN5,ATP13A4,GPC5,ZNRF3,NHSL1,SLC1A2,CDH20
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	SLC25A18,COL5A3,NPAS3,NRXN1,SORBS1,GPM6A,RYR3,PAMR1,SPARCL1,SFXN5,ATP13A4,ZNRF3,GPC5,NHSL1,SLC1A2,CDH20,TNIK,LSAMP,CLU,MSI2,CTNND2,APOE,NTRK2,ZBTB20,RANBP3L,TRPM3,PITPNC1,PREX2,NTM,SLC1A3,ACSS1,NEBL,SOX5,RORA,CPE,SLC4A4,ABLIM1,PTPRZ1,FMN2,BMPR1B,CAMK2G,FGFR3,DTNA,ATP1A2,NRG3,HIF3A,CST3,MACF1
3.237e-02	-3.43	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	31	NRG3,FGFR3
3.245e-02	-3.43	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	24	ATP1A2,CAMK2G
3.245e-02	-3.43	ErbB signaling pathway	KEGG pathways	hsa04012	85	2	7161	24	CAMK2G,NRG3
3.245e-02	-3.43	ErbB signaling pathway	KEGG pathways	ko04012	85	2	7161	24	CAMK2G,NRG3
3.251e-02	-3.43	neural precursor cell proliferation	biological process	GO:0061351	105	2	18204	49	RORA,SOX5
3.256e-02	-3.42	CarboxypepD_reg	pfam domains	PF13620	12	1	17795	49	CPE
3.264e-02	-3.42	functioning	COSMIC cancer mutations	functioning	1803	10	16828	49	NRG3,ZBTB20,NTRK2,FMN2,SLC1A2,TRPM3,PTPRZ1,NHSL1,SOX5,ZNRF3
3.264e-02	-3.42	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	10	16828	49	PTPRZ1,SOX5,NHSL1,ZNRF3,NRG3,ZBTB20,NTRK2,SLC1A2,FMN2,TRPM3
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	RORA,ATP1A2
3.276e-02	-3.42	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	42	16828	49	PTPRZ1,ABLIM1,NHSL1,GPC5,CDH20,SLC1A2,FMN2,SORBS1,SOX5,NEBL,ACSS1,NRXN1,COL5A3,NPAS3,SLC25A18,SLC1A3,ATP13A4,SFXN5,NKAIN3,CPE,SPARCL1,RORA,PAMR1,RYR3,GPM6A,RANBP3L,MACF1,PREX2,NTM,PITPNC1,TRPM3,LSAMP,CLU,BMPR1B,TNIK,HIF3A,ZBTB20,NTRK2,NRG3,CTNND2,ATP1A2,FGFR3
3.279e-02	-3.42	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	13	16828	49	RORA,CPE,NRG3,SLC1A3,COL5A3,NRXN1,ACSS1,TRPM3,FMN2,PREX2,GPC5,MACF1,PTPRZ1
3.284e-02	-3.42	chylomicron	cellular component	GO:0042627	13	1	19108	49	APOE
3.287e-02	-3.42	FOLN	smart domains	SM00274	9	1	9717	36	SPARCL1
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	50	APOE
3.291e-02	-3.41	PLPPR4 (phospholipid phosphatase related 4)	protein interactions	9890	13	1	19454	50	ZNRF3
3.291e-02	-3.41	NPR2 (natriuretic peptide receptor 2)	protein interactions	4882	13	1	19454	50	CAMK2G
3.291e-02	-3.41	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	50	NRXN1
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.296e-02	-3.41	Carboxypeptidase-like, regulatory domain	gene3d domains	2.60.40.1120	11	1	14470	44	CPE
3.307e-02	-3.41	oogenesis	biological process	GO:0048477	106	2	18204	49	BMPR1B,FMN2
3.349e-02	-3.40	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	9	18204	49	RORA,PTPRZ1,FGFR3,ATP1A2,BMPR1B,TNIK,CAMK2G,NTRK2,ACSS1
3.350e-02	-3.40	EGF_3	prosite domains	PS50026	196	3	12186	44	NRG3,NRXN1,PAMR1
3.363e-02	-3.39	TSC22D4 (TSC22 domain family member 4)	protein interactions	81628	112	2	19454	50	CLU,ABLIM1
3.379e-02	-3.39	positive regulation of cell differentiation	biological process	GO:0045597	906	6	18204	49	MACF1,RANBP3L,NTRK2,PTPRZ1,SOX5,BMPR1B
3.388e-02	-3.38	regulation of developmental process	biological process	GO:0050793	2540	12	18204	49	CST3,MACF1,BMPR1B,APOE,SOX5,PTPRZ1,NTRK2,TNIK,RANBP3L,NRXN1,RORA,FGFR3
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.396e-02	-3.38	regulation of nervous system development	biological process	GO:0051960	456	4	18204	49	NRXN1,PTPRZ1,MACF1,NTRK2
3.400e-02	-3.38	calcium ion binding	molecular function	GO:0005509	683	5	18094	48	PAMR1,MACF1,SPARCL1,NRXN1,RYR3
3.418e-02	-3.38	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	7	19454	50	FMN2,MACF1,PITPNC1,NHSL1,ABLIM1,CAMK2G,SORBS1
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	ZNRF3,DTNA
3.425e-02	-3.37	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	50	SLC1A3,GPM6A,NEBL
3.427e-02	-3.37	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	13	16828	49	PTPRZ1,SOX5,NHSL1,ZNRF3,NRG3,ZBTB20,NTRK2,FMN2,ATP1A2,SLC1A2,FGFR3,TRPM3,CTNND2
3.440e-02	-3.37	skin-benign_melanocytic_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus	12	1	16828	49	FGFR3
3.440e-02	-3.37	cervix-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	cervix-carcinoma-mixed_adenosquamous_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.440e-02	-3.37	skin-face-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-basal_cell_carcinoma	12	1	16828	49	FGFR3
3.444e-02	-3.37	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	49	ATP1A2
3.444e-02	-3.37	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	49	RORA
3.444e-02	-3.37	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	49	APOE
3.444e-02	-3.37	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	49	NRXN1
3.444e-02	-3.37	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	49	ATP1A2
3.444e-02	-3.37	prepulse inhibition	biological process	GO:0060134	13	1	18204	49	CTNNA2
3.444e-02	-3.37	ectodermal placode development	biological process	GO:0071696	13	1	18204	49	NRG3
3.444e-02	-3.37	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	49	RORA
3.444e-02	-3.37	phospholipid efflux	biological process	GO:0033700	13	1	18204	49	APOE
3.455e-02	-3.37	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	5	18094	48	TNIK,NTRK2,CAMK2G,BMPR1B,FGFR3
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	SORBS1,ATP1A2
3.459e-02	-3.36	small molecule binding	molecular function	GO:0036094	6197	23	18094	48	NRXN1,PAMR1,ACSS1,ATP1A2,ZNRF3,BMPR1B,SLC1A2,ABLIM1,FGFR3,ZBTB20,ATP13A4,MACF1,SPARCL1,CAMK2G,NTRK2,PITPNC1,RORA,SLC1A3,APOE,DTNA,TNIK,CPE,RYR3
3.464e-02	-3.36	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	4	ATP1A2
3.464e-02	-3.36	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	4	ATP1A2
3.474e-02	-3.36	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	50	MACF1,ZBTB20
3.481e-02	-3.36	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	2	18204	49	ZBTB20,CLU
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	RYR3,TRPM3
3.520e-02	-3.35	TyrKc	smart domains	SM00219	80	2	9717	36	FGFR3,NTRK2
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	BMPR1B,SOX5
3.531e-02	-3.34	Protein digestion and absorption	KEGG pathways	ko04974	89	2	7161	24	ATP1A2,COL5A3
3.531e-02	-3.34	Protein digestion and absorption	KEGG pathways	hsa04974	89	2	7161	24	ATP1A2,COL5A3
3.532e-02	-3.34	chromaffin granule	cellular component	GO:0042583	14	1	19108	49	CLU
3.538e-02	-3.34	phosphatase activity	molecular function	GO:0016791	272	3	18094	48	CAMK2G,ATP1A2,PTPRZ1
3.539e-02	-3.34	positive regulation of cell junction assembly	biological process	GO:1901890	110	2	18204	49	NTRK2,NRXN1
3.540e-02	-3.34	FGF7 (fibroblast growth factor 7)	protein interactions	2252	14	1	19454	50	FGFR3
3.540e-02	-3.34	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	50	CAMK2G
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	ZNRF3
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	50	CST3
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.540e-02	-3.34	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	50	APOE
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	CAMK2G
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	SYT5 (synaptotagmin 5)	protein interactions	6861	14	1	19454	50	NRXN1
3.540e-02	-3.34	regulation of response to stimulus	biological process	GO:0048583	4104	17	18204	49	APOE,BMPR1B,ZNRF3,MACF1,FMN2,CTNNA2,CLU,CAMK2G,RORA,SORBS1,FGFR3,PREX2,NRXN1,CTNND2,TNIK,NTRK2,GPC5
3.545e-02	-3.34	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	3	16828	49	NRG3,GPC5,NPAS3
3.545e-02	-3.34	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	3	16828	49	NRG3,NPAS3,GPC5
3.553e-02	-3.34	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	48	16828	49	ZNRF3,GPC5,NHSL1,SLC1A2,CDH20,SLC25A18,NPAS3,NRXN1,COL5A3,SORBS1,RYR3,GPM6A,SPARCL1,PAMR1,SFXN5,ATP13A4,NKAIN3,RANBP3L,TRPM3,PITPNC1,NTM,PREX2,TNIK,CLU,LSAMP,MSI2,APOE,CTNND2,ZBTB20,NTRK2,PTPRZ1,ABLIM1,FMN2,SLC1A3,ACSS1,NEBL,SOX5,CPE,RORA,SLC4A4,MACF1,BMPR1B,CAMK2G,ATP1A2,DTNA,FGFR3,NRG3,HIF3A
3.554e-02	-3.34	MIR	prosite domains	PS50919	10	1	12186	44	RYR3
3.559e-02	-3.34	Ethanol oxidation	REACTOME pathways	R-HSA-71384	12	1	10285	31	ACSS1
3.559e-02	-3.34	Signaling by activated point mutants of FGFR3	REACTOME pathways	R-HSA-1839130	12	1	10285	31	FGFR3
3.559e-02	-3.34	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	31	GPC5
3.559e-02	-3.34	FGFR3 mutant receptor activation	REACTOME pathways	R-HSA-2033514	12	1	10285	31	FGFR3
3.559e-02	-3.34	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	31	GPC5
3.559e-02	-3.34	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	31	HIF3A
3.561e-02	-3.34	regulation of membrane potential	biological process	GO:0042391	463	4	18204	49	NTRK2,ATP1A2,SLC4A4,NRXN1
3.567e-02	-3.33	positive regulation of response to stimulus	biological process	GO:0048584	2266	11	18204	49	GPC5,TNIK,NTRK2,CLU,NRXN1,MACF1,FMN2,BMPR1B,FGFR3,SORBS1,APOE
3.570e-02	-3.33	blood microparticle	cellular component	GO:0072562	116	2	19108	49	CLU,APOE
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.575e-02	-3.33	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	49	FGFR3,TNIK,CAMK2G,BMPR1B,NTRK2,PTPRZ1
3.575e-02	-3.33	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	49	PTPRZ1,NTRK2,BMPR1B,CAMK2G,TNIK,FGFR3
3.581e-02	-3.33	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	3	16828	49	FGFR3,MACF1,PTPRZ1
3.586e-02	-3.33	RBBP8 (RB binding protein 8, endonuclease)	protein interactions	5932	116	2	19454	50	CTNNA2,CLU
3.586e-02	-3.33	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	2	19454	50	SPARCL1,MACF1
3.590e-02	-3.33	-	gene3d domains	3.10.450.50	12	1	14470	44	CAMK2G
3.590e-02	-3.33	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	44	CTNNA2
3.603e-02	-3.32	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	18	16828	49	ACSS1,NEBL,COL5A3,PAMR1,RORA,NRG3,ATP13A4,SLC4A4,FGFR3,ATP1A2,CTNND2,ABLIM1,GPC5,MACF1,PREX2,SLC1A2,FMN2,CDH20
3.604e-02	-3.32	rhythmic process	biological process	GO:0048511	270	3	18204	49	BMPR1B,NTRK2,RORA
3.610e-02	-3.32	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	13	16828	49	PTPRZ1,PREX2,CDH20,SOX5,NEBL,SLC1A3,NRXN1,LSAMP,NRG3,ATP13A4,ATP1A2,CTNND2,RYR3
3.627e-02	-3.32	Ion_trans	pfam domains	PF00520	109	2	17795	49	TRPM3,RYR3
3.645e-02	-3.31	MIR	smart domains	SM00472	10	1	9717	36	RYR3
3.647e-02	-3.31	phosphorus metabolic process	biological process	GO:0006793	1707	9	18204	49	CAMK2G,TNIK,NTRK2,ACSS1,ATP1A2,BMPR1B,RORA,FGFR3,PTPRZ1
3.647e-02	-3.31	HYOU1 (hypoxia up-regulated 1)	protein interactions	10525	284	3	19454	50	FGFR3,CPE,CLU
3.647e-02	-3.31	Dppa3 (developmental pluripotency-associated 3)	protein interactions	73708	284	3	19454	50	MSI2,ATP1A2,CAMK2G
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.661e-02	-3.31	SNX27 (sorting nexin 27)	protein interactions	81609	489	4	19454	50	COL5A3,ABLIM1,CLU,SLC1A3
3.668e-02	-3.31	CAV1 (caveolin 1)	protein interactions	857	719	5	19454	50	MACF1,DTNA,FMN2,TNIK,SLC1A3
3.675e-02	-3.30	SHC1 events in EGFR signaling	REACTOME pathways	R-HSA-180336	245	3	10285	31	FGFR3,NRG3,CAMK2G
3.675e-02	-3.30	RAF/MAP kinase cascade	REACTOME pathways	R-HSA-5673001	245	3	10285	31	NRG3,CAMK2G,FGFR3
3.675e-02	-3.30	SOS-mediated signalling	REACTOME pathways	R-HSA-112412	245	3	10285	31	NRG3,CAMK2G,FGFR3
3.675e-02	-3.30	GRB2 events in EGFR signaling	REACTOME pathways	R-HSA-179812	245	3	10285	31	FGFR3,CAMK2G,NRG3
3.678e-02	-3.30	HLH_DNA-bd_sf	interpro domains	IPR036638	112	2	18521	50	NPAS3,HIF3A
3.678e-02	-3.30	bHLH_dom	interpro domains	IPR011598	112	2	18521	50	NPAS3,HIF3A
3.691e-02	-3.30	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	2	10285	31	APOE,GPC5
3.704e-02	-3.30	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	49	TNIK,NTRK2,CTNND2,MACF1,CPE,ZNRF3,BMPR1B,NRG3,FGFR3,SORBS1
3.704e-02	-3.30	acetyl-CoA biosynthetic process	biological process	GO:0006085	14	1	18204	49	ACSS1
3.704e-02	-3.30	regulation of skeletal muscle adaptation	biological process	GO:0014733	14	1	18204	49	CAMK2G
3.704e-02	-3.30	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	49	APOE
3.704e-02	-3.30	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	49	ATP1A2
3.704e-02	-3.30	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	49	ATP1A2
3.704e-02	-3.30	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	49	APOE
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	RYR3
3.704e-02	-3.30	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	49	SLC1A2
3.715e-02	-3.29	Neurexin-like	interpro domains	IPR003585	14	1	18521	50	NRXN1
3.717e-02	-3.29	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	2	18204	49	CLU,ZBTB20
3.721e-02	-3.29	Brenner_tumour	COSMIC cancer mutations	Brenner_tumour	13	1	16828	49	FGFR3
3.721e-02	-3.29	endometrium-ovary-endometriosis	COSMIC cancer mutations	endometrium-ovary-endometriosis	13	1	16828	49	FGFR3
3.721e-02	-3.29	cervix-carcinoma-adenocarcinoma	COSMIC cancer mutations	cervix-carcinoma-adenocarcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	skin-back-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-back-carcinoma-basal_cell_carcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.745e-02	-3.28	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	3	19454	50	NTRK2,SORBS1,DTNA
3.749e-02	-3.28	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	4	ATP1A2
3.750e-02	-3.28	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	2	16828	49	NRG3,GPC5
3.756e-02	-3.28	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	50	CLU,APOE
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.768e-02	-3.28	ATP binding	molecular function	GO:0005524	1467	8	18094	48	TNIK,FGFR3,ATP13A4,CAMK2G,NTRK2,ACSS1,ATP1A2,BMPR1B
3.774e-02	-3.28	gliogenesis	biological process	GO:0042063	275	3	18204	49	CLU,PTPRZ1,NTRK2
3.777e-02	-3.28	negative regulation of protein catabolic process	biological process	GO:0042177	114	2	18204	49	FMN2,CST3
3.780e-02	-3.28	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	49	APOE
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	50	TNIK
3.788e-02	-3.27	FGF9 (fibroblast growth factor 9)	protein interactions	2254	15	1	19454	50	FGFR3
3.806e-02	-3.27	positive regulation of MAPK cascade	biological process	GO:0043410	473	4	18204	49	APOE,FGFR3,NTRK2,TNIK
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	ABLIM1,NEBL,SORBS1
3.819e-02	-3.27	circulatory system development	biological process	GO:0072359	933	6	18204	49	HIF3A,NTRK2,CPE,APOE,RORA,NEBL
3.819e-02	-3.27	membrane raft	cellular component	GO:0045121	290	3	19108	49	SORBS1,SLC1A2,ATP1A2
3.828e-02	-3.26	ARMS-mediated activation	REACTOME pathways	R-HSA-170984	249	3	10285	31	FGFR3,CAMK2G,NRG3
3.828e-02	-3.26	Signalling to p38 via RIT and RIN	REACTOME pathways	R-HSA-187706	249	3	10285	31	FGFR3,NRG3,CAMK2G
3.850e-02	-3.26	FGFR3c ligand binding and activation	REACTOME pathways	R-HSA-190372	13	1	10285	31	FGFR3
3.850e-02	-3.26	FGFR3 ligand binding and activation	REACTOME pathways	R-HSA-190239	13	1	10285	31	FGFR3
3.850e-02	-3.26	Phospholipase C-mediated cascade; FGFR3	REACTOME pathways	R-HSA-5654227	13	1	10285	31	FGFR3
3.850e-02	-3.26	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	31	NRG3
3.867e-02	-3.25	Frs2-mediated activation	REACTOME pathways	R-HSA-170968	250	3	10285	31	FGFR3,CAMK2G,NRG3
3.868e-02	-3.25	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	5	18204	49	NTRK2,TNIK,FGFR3,ZBTB20,SLC4A4
3.868e-02	-3.25	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	5	18204	49	FGFR3,ZBTB20,SLC4A4,TNIK,NTRK2
3.876e-02	-3.25	GOPC (golgi associated PDZ and coiled-coil motif containing)	protein interactions	57120	291	3	19454	50	NTRK2,FGFR3,SLC25A18
3.878e-02	-3.25	actin filament organization	biological process	GO:0007015	278	3	18204	49	FMN2,SORBS1,NEBL
3.881e-02	-3.25	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	2	16828	49	HIF3A,NEBL
3.885e-02	-3.25	membrane microdomain	cellular component	GO:0098857	292	3	19108	49	SLC1A2,ATP1A2,SORBS1
3.888e-02	-3.25	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	21	APOE
3.893e-02	-3.25	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	31	RYR3,TRPM3
3.902e-02	-3.24	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	44	NTRK2
3.902e-02	-3.24	RANBD1	prosite domains	PS50196	11	1	12186	44	RANBP3L
3.902e-02	-3.24	NC1_FIB	prosite domains	PS51461	11	1	12186	44	COL5A3
3.906e-02	-3.24	MAPK1/MAPK3 signaling	REACTOME pathways	R-HSA-5684996	251	3	10285	31	FGFR3,CAMK2G,NRG3
3.908e-02	-3.24	filamin binding	molecular function	GO:0031005	15	1	18094	48	NEBL
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.908e-02	-3.24	AMP binding	molecular function	GO:0016208	15	1	18094	48	ACSS1
3.908e-02	-3.24	neurexin family protein binding	molecular function	GO:0042043	15	1	18094	48	CPE
3.908e-02	-3.24	C4-dicarboxylate transmembrane transporter activity	molecular function	GO:0015556	15	1	18094	48	SLC25A18
3.908e-02	-3.24	tropomyosin binding	molecular function	GO:0005523	15	1	18094	48	NEBL
3.919e-02	-3.24	homeostatic process	biological process	GO:0042592	1456	8	18204	49	SLC4A4,SLC1A3,ATP13A4,RYR3,ATP1A2,RORA,ZBTB20,APOE
3.930e-02	-3.24	SLMAP (sarcolemma associated protein)	protein interactions	7871	122	2	19454	50	CAMK2G,TNIK
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	DTNA,NHSL1
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.943e-02	-3.23	human chr4q32.3	chromosome location	human chr4q32.3	21	1	26134	50	CPE
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.945e-02	-3.23	Prolonged ERK activation events	REACTOME pathways	R-HSA-169893	252	3	10285	31	CAMK2G,NRG3,FGFR3
3.949e-02	-3.23	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	21	SLC4A4
3.959e-02	-3.23	regulation of synapse assembly	biological process	GO:0051963	117	2	18204	49	NTRK2,NRXN1
3.964e-02	-3.23	response to caffeine	biological process	GO:0031000	15	1	18204	49	RYR3
3.964e-02	-3.23	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	49	NTRK2
3.964e-02	-3.23	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	49	MACF1
3.964e-02	-3.23	protein homotrimerization	biological process	GO:0070207	15	1	18204	49	SLC1A2
3.964e-02	-3.23	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	49	APOE
3.964e-02	-3.23	neuroblast division	biological process	GO:0055057	15	1	18204	49	SOX5
3.964e-02	-3.23	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	49	ATP1A2
3.964e-02	-3.23	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	49	SORBS1
3.964e-02	-3.23	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	49	RORA
3.964e-02	-3.23	chondrocyte proliferation	biological process	GO:0035988	15	1	18204	49	FGFR3
3.964e-02	-3.23	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	49	RYR3
3.964e-02	-3.23	regulation of phospholipid transport	biological process	GO:2001138	15	1	18204	49	APOE
3.964e-02	-3.23	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	49	NTRK2
3.964e-02	-3.23	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	49	APOE
3.964e-02	-3.23	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	49	ATP1A2
3.967e-02	-3.23	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	46	16828	49	SLC1A3,NEBL,SOX5,ACSS1,SLC4A4,RORA,CPE,ABLIM1,PTPRZ1,FMN2,CAMK2G,BMPR1B,DTNA,FGFR3,ATP1A2,HIF3A,NRG3,MACF1,COL5A3,NRXN1,NPAS3,SLC25A18,SORBS1,GPM6A,RYR3,ATP13A4,NKAIN3,SFXN5,PAMR1,SPARCL1,GPC5,ZNRF3,NHSL1,CDH20,SLC1A2,LSAMP,CLU,TNIK,CTNND2,NTRK2,ZBTB20,RANBP3L,TRPM3,NTM,PREX2,PITPNC1
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	NTF2-like_dom_sf	interpro domains	IPR032710	15	1	18521	50	CAMK2G
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.978e-02	-3.22	Pancreatic secretion	KEGG pathways	hsa04972	95	2	7161	24	SLC4A4,ATP1A2
3.978e-02	-3.22	Pancreatic secretion	KEGG pathways	ko04972	95	2	7161	24	SLC4A4,ATP1A2
3.984e-02	-3.22	Signaling by Leptin	REACTOME pathways	R-HSA-2586552	253	3	10285	31	NRG3,CAMK2G,FGFR3
4.002e-02	-3.22	in_situ_neoplasm	COSMIC cancer mutations	in_situ_neoplasm	14	1	16828	49	FGFR3
4.002e-02	-3.22	soft_tissue-small_round_cell_tumour	COSMIC cancer mutations	soft_tissue-small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	endometriosis	COSMIC cancer mutations	endometriosis	14	1	16828	49	FGFR3
4.002e-02	-3.22	small_round_cell_tumour	COSMIC cancer mutations	small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	14	1	16828	49	FGFR3
4.003e-02	-3.22	RanBD	smart domains	SM00160	11	1	9717	36	RANBP3L
4.003e-02	-3.22	COLFI	smart domains	SM00038	11	1	9717	36	COL5A3
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.035e-02	-3.21	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	50	APOE
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	ZNRF3
4.035e-02	-3.21	HLA-H (major histocompatibility complex, class I, H (pseudogene))	protein interactions	3136	16	1	19454	50	FGFR3
4.035e-02	-3.21	CTSK (cathepsin K)	protein interactions	1513	16	1	19454	50	FGFR3
4.035e-02	-3.21	DUS1L (dihydrouridine synthase 1 like)	protein interactions	64118	16	1	19454	50	CAMK2G
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	50	NRXN1
4.035e-02	-3.21	CAMK1G (calcium/calmodulin dependent protein kinase IG)	protein interactions	57172	16	1	19454	50	CAMK2G
4.035e-02	-3.21	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	50	NRXN1
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	SYT4 (synaptotagmin 4)	protein interactions	6860	16	1	19454	50	NRXN1
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	FMN2
4.054e-02	-3.21	Circadian entrainment	KEGG pathways	ko04713	96	2	7161	24	RYR3,CAMK2G
4.054e-02	-3.21	Circadian entrainment	KEGG pathways	hsa04713	96	2	7161	24	RYR3,CAMK2G
4.063e-02	-3.20	Interleukin receptor SHC signaling	REACTOME pathways	R-HSA-912526	255	3	10285	31	FGFR3,CAMK2G,NRG3
4.082e-02	-3.20	metal ion binding	molecular function	GO:0046872	4239	17	18094	48	MACF1,CPE,RYR3,ABLIM1,DTNA,ATP13A4,ZBTB20,ATP1A2,ZNRF3,RORA,APOE,SLC1A2,BMPR1B,SLC1A3,SPARCL1,NRXN1,PAMR1
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	NTM,FGFR3,LSAMP,NTRK2
4.103e-02	-3.19	Signalling to RAS	REACTOME pathways	R-HSA-167044	256	3	10285	31	NRG3,CAMK2G,FGFR3
4.114e-02	-3.19	protein-containing complex binding	molecular function	GO:0044877	1772	9	18094	48	CTNNA2,PTPRZ1,APOE,MACF1,NEBL,COL5A3,SPARCL1,ABLIM1,CLU
4.117e-02	-3.19	signaling receptor binding	molecular function	GO:0005102	1493	8	18094	48	SORBS1,CPE,ZNRF3,PTPRZ1,APOE,NRXN1,CLU,NRG3
4.141e-02	-3.18	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	31	ABLIM1
4.141e-02	-3.18	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	31	NRG3
4.145e-02	-3.18	skin-acral-malignant_melanoma	COSMIC cancer mutations	skin-acral-malignant_melanoma	264	3	16828	49	COL5A3,CDH20,FMN2
4.146e-02	-3.18	upper_leg	COSMIC cancer mutations	upper_leg	880	6	16828	49	FGFR3,FMN2,PREX2,HIF3A,PAMR1,ACSS1
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.163e-02	-3.18	misfolded protein binding	molecular function	GO:0051787	16	1	18094	48	CLU
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.184e-02	-3.17	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	3	10285	31	CAMK2G,NRG3,FGFR3
4.223e-02	-3.16	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	49	ATP1A2
4.223e-02	-3.16	insulin metabolic process	biological process	GO:1901142	16	1	18204	49	CPE
4.223e-02	-3.16	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	49	ATP1A2
4.223e-02	-3.16	short-chain fatty acid metabolic process	biological process	GO:0046459	16	1	18204	49	ACSS1
4.223e-02	-3.16	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	49	APOE
4.223e-02	-3.16	neuron cell-cell adhesion	biological process	GO:0007158	16	1	18204	49	NRXN1
4.223e-02	-3.16	cardiac left ventricle morphogenesis	biological process	GO:0003214	16	1	18204	49	CPE
4.223e-02	-3.16	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	49	SLC1A3
4.223e-02	-3.16	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	49	ATP1A2
4.223e-02	-3.16	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	49	APOE
4.223e-02	-3.16	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	49	ZNRF3
4.223e-02	-3.16	asymmetric cell division	biological process	GO:0008356	16	1	18204	49	SOX5
4.223e-02	-3.16	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	49	SLC1A2
4.225e-02	-3.16	EF_HAND_2	prosite domains	PS50222	215	3	12186	44	SPARCL1,MACF1,RYR3
4.235e-02	-3.16	CarboxyPept-like_regulatory	interpro domains	IPR008969	16	1	18521	50	CPE
4.267e-02	-3.15	neuron projection terminus	cellular component	GO:0044306	128	2	19108	49	NTRK2,SLC1A2
4.273e-02	-3.15	apical dendrite	cellular component	GO:0097440	17	1	19108	49	CLU
4.274e-02	-3.15	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	7	16828	49	NTRK2,RORA,CTNND2,RYR3,FGFR3,TNIK,CAMK2G
4.282e-02	-3.15	ureter	COSMIC cancer mutations	ureter	15	1	16828	49	FGFR3
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	FAM163B (family with sequence similarity 163 member B)	protein interactions	642968	17	1	19454	50	CAMK2G
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	50	APOE
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	KRTAP19-3 (keratin associated protein 19-3)	protein interactions	337970	17	1	19454	50	CAMK2G
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.302e-02	-3.15	acral	COSMIC cancer mutations	acral	268	3	16828	49	CDH20,COL5A3,FMN2
4.304e-02	-3.15	SH3DOMAIN	prints domains	PR00452	83	2	5227	21	SORBS1,NEBL
4.321e-02	-3.14	CARM1 (coactivator associated arginine methyltransferase 1)	protein interactions	10498	304	3	19454	50	CAMK2G,RORA,DTNA
4.346e-02	-3.14	POLA2 (DNA polymerase alpha 2, accessory subunit)	protein interactions	23649	129	2	19454	50	CPE,FGFR3
4.346e-02	-3.14	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	2	19454	50	ABLIM1,ZBTB20
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	ZBTB20,SOX5
4.347e-02	-3.14	Interleukin-2 signaling	REACTOME pathways	R-HSA-451927	262	3	10285	31	FGFR3,NRG3,CAMK2G
4.350e-02	-3.13	cellular response to growth factor stimulus	biological process	GO:0071363	494	4	18204	49	NTRK2,BMPR1B,SOX5,FGFR3
4.362e-02	-3.13	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	6	16828	49	NPAS3,FGFR3,ATP1A2,ABLIM1,PTPRZ1,SPARCL1
4.388e-02	-3.13	Z disc	cellular component	GO:0030018	130	2	19108	49	RYR3,NEBL
4.388e-02	-3.13	Signalling to ERKs	REACTOME pathways	R-HSA-187687	263	3	10285	31	CAMK2G,NRG3,FGFR3
4.397e-02	-3.12	action potential	biological process	GO:0001508	124	2	18204	49	NTRK2,ATP1A2
4.417e-02	-3.12	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	48	PTPRZ1
4.417e-02	-3.12	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	48	PTPRZ1
4.424e-02	-3.12	Ig-like_fold	interpro domains	IPR013783	721	5	18521	50	NTM,FGFR3,PTPRZ1,NTRK2,LSAMP
4.430e-02	-3.12	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	31	NRG3
4.432e-02	-3.12	endomembrane system	cellular component	GO:0012505	4764	18	19108	49	TNIK,RYR3,FGFR3,GPC5,CLU,APOE,CPE,CAMK2G,MACF1,SPARCL1,ATP13A4,NRXN1,FMN2,COL5A3,CST3,RANBP3L,ATP1A2,NTRK2
4.461e-02	-3.11	actomyosin structure organization	biological process	GO:0031032	125	2	18204	49	SORBS1,NEBL
4.467e-02	-3.11	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	44	FMN2
4.472e-02	-3.11	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	8	16828	49	MACF1,RYR3,CTNND2,ATP1A2,FGFR3,TRPM3,ATP13A4,CPE
4.472e-02	-3.11	FCERI mediated MAPK activation	REACTOME pathways	R-HSA-2871796	265	3	10285	31	FGFR3,NRG3,CAMK2G
4.477e-02	-3.11	Helix-loop-helix DNA-binding domain	gene3d domains	4.10.280.10	111	2	14470	44	HIF3A,NPAS3
4.481e-02	-3.11	cell population proliferation	biological process	GO:0008283	726	5	18204	49	ZNRF3,RORA,SOX5,FGFR3,CLU
4.481e-02	-3.11	microvillus assembly	biological process	GO:0030033	17	1	18204	49	TNIK
4.481e-02	-3.11	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	49	APOE
4.481e-02	-3.11	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	49	RORA
4.481e-02	-3.11	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	49	CTNNA2
4.481e-02	-3.11	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	49	APOE
4.481e-02	-3.11	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	49	CLU
4.481e-02	-3.11	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	49	NTRK2
4.481e-02	-3.11	cGMP metabolic process	biological process	GO:0046068	17	1	18204	49	RORA
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	SLC1A2
4.481e-02	-3.11	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	49	APOE
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	RYR3
4.481e-02	-3.11	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	49	APOE
4.481e-02	-3.11	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	49	SORBS1
4.481e-02	-3.11	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	49	ATP1A2
4.481e-02	-3.11	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	49	ATP1A2
4.493e-02	-3.10	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	3	18204	49	NTRK2,APOE,FGFR3
4.493e-02	-3.10	AMP-bd_C	interpro domains	IPR025110	17	1	18521	50	ACSS1
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	PAC	interpro domains	IPR001610	17	1	18521	50	HIF3A
4.493e-02	-3.10	Cystatin_dom	interpro domains	IPR000010	17	1	18521	50	CST3
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	NTRK2,ZBTB20,CTNND2,APOE,MSI2,TNIK,LSAMP,CLU,PITPNC1,PREX2,NTM,TRPM3,RANBP3L,PAMR1,SPARCL1,SFXN5,ATP13A4,NKAIN3,GPM6A,RYR3,SORBS1,SLC25A18,COL5A3,NRXN1,NPAS3,SLC1A2,CDH20,NHSL1,GPC5,ZNRF3,NRG3,HIF3A,FGFR3,DTNA,ATP1A2,BMPR1B,CAMK2G,CST3,MACF1,RORA,CPE,SLC4A4,ACSS1,SOX5,NEBL,SLC1A3,FMN2,ABLIM1,PTPRZ1
4.514e-02	-3.10	skeletal system development	biological process	GO:0001501	500	4	18204	49	RANBP3L,BMPR1B,SOX5,FGFR3
4.517e-02	-3.10	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	44	NTRK2,FGFR3
4.525e-02	-3.10	kinase activity	molecular function	GO:0016301	739	5	18094	48	CAMK2G,NTRK2,TNIK,FGFR3,BMPR1B
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	FGFR3
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	50	APOE
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.530e-02	-3.09	GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1)	protein interactions	338328	132	2	19454	50	CPE,FGFR3
4.530e-02	-3.09	STRN (striatin)	protein interactions	6801	132	2	19454	50	TNIK,CAMK2G
4.547e-02	-3.09	phosphorylation	biological process	GO:0016310	729	5	18204	49	FGFR3,CAMK2G,NTRK2,TNIK,BMPR1B
4.557e-02	-3.09	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	7	16828	49	NTRK2,RORA,RYR3,CTNND2,FGFR3,CAMK2G,TNIK
4.561e-02	-3.09	normal	COSMIC cancer mutations	normal	16	1	16828	49	FGFR3
4.561e-02	-3.09	urinary_tract-carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma	16	1	16828	49	FGFR3
4.561e-02	-3.09	renal_pelvis	COSMIC cancer mutations	renal_pelvis	16	1	16828	49	FGFR3
4.561e-02	-3.09	flank	COSMIC cancer mutations	flank	16	1	16828	49	FGFR3
4.569e-02	-3.09	muscle system process	biological process	GO:0003012	297	3	18204	49	RYR3,ATP1A2,DTNA
4.574e-02	-3.08	SH3	prosite domains	PS50002	222	3	12186	44	MACF1,NEBL,SORBS1
4.581e-02	-3.08	AMP-binding_C	pfam domains	PF13193	17	1	17795	49	ACSS1
4.581e-02	-3.08	Cystatin	pfam domains	PF00031	17	1	17795	49	CST3
4.581e-02	-3.08	ZZ	pfam domains	PF00569	17	1	17795	49	DTNA
4.581e-02	-3.08	Carb_anhydrase	pfam domains	PF00194	17	1	17795	49	PTPRZ1
4.590e-02	-3.08	response to amino acid	biological process	GO:0043200	127	2	18204	49	NTRK2,SLC1A2
4.596e-02	-3.08	CARBOXYPEPT_ZN_1	prosite domains	PS00132	13	1	12186	44	CPE
4.596e-02	-3.08	CARBOXYPEPT_ZN_2	prosite domains	PS00133	13	1	12186	44	CPE
4.606e-02	-3.08	extraskeletal	COSMIC cancer mutations	extraskeletal	903	6	16828	49	ABLIM1,PTPRZ1,SPARCL1,NPAS3,FGFR3,ATP1A2
4.621e-02	-3.07	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	8	18094	48	NTRK2,CAMK2G,ACSS1,ATP1A2,BMPR1B,TNIK,FGFR3,ATP13A4
4.623e-02	-3.07	intracellular signal transduction	biological process	GO:0035556	1505	8	18204	49	FGFR3,APOE,ATP1A2,PREX2,RYR3,NRG3,FMN2,TNIK
4.649e-02	-3.07	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	21	RYR3
4.649e-02	-3.07	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	21	BMPR1B
4.652e-02	-3.07	cellular response to organonitrogen compound	biological process	GO:0071417	505	4	18204	49	SORBS1,SLC1A3,SLC1A2,RYR3
4.655e-02	-3.07	glial cell development	biological process	GO:0021782	128	2	18204	49	NTRK2,CLU
4.655e-02	-3.07	myelination	biological process	GO:0042552	128	2	18204	49	CLU,NTRK2
4.671e-02	-3.06	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	48	APOE
4.671e-02	-3.06	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	48	NRG3
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.671e-02	-3.06	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	48	RYR3
4.674e-02	-3.06	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	5	19454	50	CLU,FGFR3,NTRK2,SLC1A2,MSI2
4.683e-02	-3.06	RET signaling	REACTOME pathways	R-HSA-8853659	270	3	10285	31	NRG3,CAMK2G,FGFR3
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	ABLIM1,CAMK2G
4.716e-02	-3.05	BMP4 (bone morphogenetic protein 4)	protein interactions	652	135	2	19454	50	CLU,BMPR1B
4.718e-02	-3.05	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	1	10285	31	NRG3
4.718e-02	-3.05	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	31	NRG3
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	RYR3,GPM6A,SPARCL1,PAMR1,NKAIN3,ATP13A4,SFXN5,SLC25A18,NPAS3,NRXN1,COL5A3,SORBS1,SLC1A2,CDH20,GPC5,ZNRF3,NHSL1,APOE,CTNND2,ZBTB20,NTRK2,TNIK,CLU,LSAMP,MSI2,TRPM3,PITPNC1,PREX2,NTM,RANBP3L,CPE,RORA,SLC4A4,SLC1A3,ACSS1,NEBL,SOX5,FMN2,PTPRZ1,ABLIM1,ATP1A2,DTNA,FGFR3,NRG3,HIF3A,CAMK2G,BMPR1B,CST3,MACF1
4.726e-02	-3.05	Interleukin-3, 5 and GM-CSF signaling	REACTOME pathways	R-HSA-512988	271	3	10285	31	FGFR3,CAMK2G,NRG3
4.738e-02	-3.05	myelin maintenance	biological process	GO:0043217	18	1	18204	49	CLU
4.738e-02	-3.05	response to misfolded protein	biological process	GO:0051788	18	1	18204	49	CLU
4.738e-02	-3.05	receptor catabolic process	biological process	GO:0032801	18	1	18204	49	ZNRF3
4.738e-02	-3.05	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	49	CTNND2
4.738e-02	-3.05	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	49	CST3
4.738e-02	-3.05	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	49	NEBL
4.738e-02	-3.05	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	49	ATP1A2
4.738e-02	-3.05	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	49	RORA
4.738e-02	-3.05	negative regulation of platelet activation	biological process	GO:0010544	18	1	18204	49	APOE
4.738e-02	-3.05	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	49	NTRK2
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	NTRK2,TNIK,CTNND2
4.764e-02	-3.04	astrocyte projection	cellular component	GO:0097449	19	1	19108	49	SLC1A2
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.772e-02	-3.04	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	49	CTNND2,FMN2
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)	protein interactions	6236	19	1	19454	50	CAMK2G
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	NLGN1 (neuroligin 1)	protein interactions	22871	19	1	19454	50	NRXN1
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	50	NRXN1
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	Mtx1 (metaxin 1)	protein interactions	17827	19	1	19454	50	CAMK2G
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	50	CAMK2G
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.786e-02	-3.04	axon ensheathment	biological process	GO:0008366	130	2	18204	49	NTRK2,CLU
4.786e-02	-3.04	ensheathment of neurons	biological process	GO:0007272	130	2	18204	49	NTRK2,CLU
4.793e-02	-3.04	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	3	16828	49	PREX2,TNIK,ATP1A2
4.839e-02	-3.03	skin-non_chronically_sun_exposed_site-malignant_melanoma	COSMIC cancer mutations	skin-non_chronically_sun_exposed_site-malignant_melanoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-other-verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	skin-other-verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	breast-carcinoma-neuroendocrine_carcinoma	COSMIC cancer mutations	breast-carcinoma-neuroendocrine_carcinoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	non_chronically_sun_exposed_site	COSMIC cancer mutations	non_chronically_sun_exposed_site	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.856e-02	-3.02	protein-folding chaperone binding	molecular function	GO:0051087	133	2	18094	48	ATP1A2,CLU
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.937e-02	-3.01	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	4	18204	49	NTRK2,GPM6A,NRXN1,CLU
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	DTNA,SORBS1,MACF1
4.944e-02	-3.01	NCAM signaling for neurite out-growth	REACTOME pathways	R-HSA-375165	276	3	10285	31	FGFR3,CAMK2G,NRG3
4.968e-02	-3.00	KRTAP9-3 (keratin associated protein 9-3)	protein interactions	83900	139	2	19454	50	SLC25A18,NTM
4.968e-02	-3.00	NEFM (neurofilament medium chain)	protein interactions	4741	139	2	19454	50	APOE,TNIK
4.985e-02	-3.00	regulation of sequestering of calcium ion	biological process	GO:0051282	133	2	18204	49	ATP1A2,RYR3
4.995e-02	-3.00	cerebellar Purkinje cell layer morphogenesis	biological process	GO:0021692	19	1	18204	49	RORA
4.995e-02	-3.00	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	49	APOE
4.995e-02	-3.00	excitatory synapse assembly	biological process	GO:1904861	19	1	18204	49	NRXN1
4.995e-02	-3.00	vocalization behavior	biological process	GO:0071625	19	1	18204	49	NRXN1
4.995e-02	-3.00	regulation of neurotransmitter uptake	biological process	GO:0051580	19	1	18204	49	ATP1A2
4.995e-02	-3.00	response to potassium ion	biological process	GO:0035864	19	1	18204	49	ATP1A2
4.995e-02	-3.00	microvillus organization	biological process	GO:0032528	19	1	18204	49	TNIK