TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols WP430 Statin Pathway 0.00730613523678847 -4.9190408404069 33 2 0.0952380952380952 21 5310 348,84532 APOE,ACSS1 WP2447 Amyotrophic lateral sclerosis (ALS) 0.00961277880940606 -4.64466193969131 38 2 0.0952380952380952 21 5310 6506,1471 SLC1A2,CST3 WP2267 Synaptic Vesicle Pathway 0.0175392941949017 -4.04331153259109 52 2 0.0952380952380952 21 5310 6507,477 SLC1A3,ATP1A2 WP706 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 0.0247626742136015 -3.69841783160204 162 3 0.142857142857143 21 5310 4915,6507,6095 NTRK2,SLC1A3,RORA WP474 Endochondral Ossification 0.0266789504139335 -3.62388039851614 65 2 0.0952380952380952 21 5310 6660,2261 SOX5,FGFR3 WP3601 Composition of Lipid Particles 0.0388839525329923 -3.24717364475772 10 1 0.0476190476190476 21 5310 348 APOE WP3301 MFAP5-mediated ovarian cancer cell motility and invasiveness 0.0464859705913827 -3.06860471962396 12 1 0.0476190476190476 21 5310 6263 RYR3 WP1425 Bone Morphogenic Protein (BMP) Signalling and Regulation 0.0464859705913827 -3.06860471962396 12 1 0.0476190476190476 21 5310 658 BMPR1B WP3679 Cell-type Dependent Selectivity of CCK2R Signaling 0.0502654712734123 -2.99043689339208 13 1 0.0476190476190476 21 5310 6263 RYR3 WP3853 ERK Pathway in Huntington's Disease 0.0540307016128648 -2.91820284559388 14 1 0.0476190476190476 21 5310 4915 NTRK2 WP2064 Neural Crest Differentiation 0.0605529907432812 -2.80423641725021 102 2 0.0952380952380952 21 5310 6660,2261 SOX5,FGFR3 WP3413 NOTCH1 regulation of human endothelial cell calcification 0.0689499408475414 -2.67437453264687 18 1 0.0476190476190476 21 5310 2261 FGFR3 WP2858 Ectoderm Differentiation 0.108441995045274 -2.22153985683303 143 2 0.0952380952380952 21 5310 1501,1496 CTNND2,CTNNA2 WP2059 Alzheimers Disease 0.114841163796552 -2.16420528971103 148 2 0.0952380952380952 21 5310 348,6263 APOE,RYR3 WP536 Calcium Regulation in the Cardiac Cell 0.118728919666269 -2.13091237042551 151 2 0.0952380952380952 21 5310 6263,818 RYR3,CAMK2G WP2828 Bladder Cancer 0.119422148199577 -2.12509059941701 32 1 0.0476190476190476 21 5310 2261 FGFR3 WP34 Ovarian Infertility Genes 0.119422148199577 -2.12509059941701 32 1 0.0476190476190476 21 5310 658 BMPR1B WP3893 Development and heterogeneity of the ILC family 0.119422148199577 -2.12509059941701 32 1 0.0476190476190476 21 5310 6095 RORA WP3676 BDNF-TrkB Signaling 0.122925773604899 -2.09617457239583 33 1 0.0476190476190476 21 5310 4915 NTRK2 WP289 Myometrial Relaxation and Contraction Pathways 0.127932811166787 -2.05625006563693 158 2 0.0952380952380952 21 5310 6263,818 RYR3,CAMK2G WP3298 Melatonin metabolism and effects 0.133357167816507 -2.01472427789388 36 1 0.0476190476190476 21 5310 348 APOE WP170 Nuclear Receptors 0.143670338118455 -1.94023392252416 39 1 0.0476190476190476 21 5310 6095 RORA WP2911 miRNA targets in ECM and membrane receptors 0.157239527422469 -1.84998498388664 43 1 0.0476190476190476 21 5310 50509 COL5A3 WP1533 Vitamin B12 Metabolism 0.19027235711767 -1.65929877472849 53 1 0.0476190476190476 21 5310 348 APOE WP673 ErbB Signaling Pathway 0.193506954891567 -1.64244182456614 54 1 0.0476190476190476 21 5310 10718 NRG3 WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer 0.193506954891567 -1.64244182456614 54 1 0.0476190476190476 21 5310 348 APOE WP3594 Circadian rythm related genes 0.196390564335124 -1.62764992731606 207 2 0.0952380952380952 21 5310 1471,6095 CST3,RORA WP558 Complement and Coagulation Cascades 0.212657621344107 -1.54807181807471 60 1 0.0476190476190476 21 5310 1191 CLU WP1982 Sterol Regulatory Element-Binding Proteins (SREBP) signalling 0.252675753338008 -1.37564821957534 73 1 0.0476190476190476 21 5310 84532 ACSS1 WP2118 Arrhythmogenic Right Ventricular Cardiomyopathy 0.261631607399079 -1.34081784330668 76 1 0.0476190476190476 21 5310 1496 CTNNA2 WP3925 Amino Acid metabolism 0.304898805738812 -1.18777534189028 91 1 0.0476190476190476 21 5310 84532 ACSS1 WP185 Integrin-mediated Cell Adhesion 0.337762829653723 -1.08541131721198 103 1 0.0476190476190476 21 5310 10580 SORBS1 WP2431 Spinal Cord Injury 0.379285486947197 -0.969466093747511 119 1 0.0476190476190476 21 5310 5803 PTPRZ1 WP236 Adipogenesis 0.408787499180871 -0.894559819863351 131 1 0.0476190476190476 21 5310 6095 RORA WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 0.439239410588139 -0.822710660143747 144 1 0.0476190476190476 21 5310 4915 NTRK2 WP51 Regulation of Actin Cytoskeleton 0.450549039995826 -0.797288351041734 149 1 0.0476190476190476 21 5310 2261 FGFR3 WP2857 Mesodermal Commitment Pathway 0.463833919906356 -0.768228722064859 155 1 0.0476190476190476 21 5310 23499 MACF1 WP481 Insulin Signaling 0.47681253410941 -0.740631875595375 161 1 0.0476190476190476 21 5310 10580 SORBS1 WP306 Focal Adhesion 0.544889401007272 -0.60717243884438 195 1 0.0476190476190476 21 5310 50509 COL5A3 WP2377 Integrated Pancreatic Cancer Pathway 0.54861907218461 -0.600350935890422 197 1 0.0476190476190476 21 5310 1471 CST3 WP383 Striated Muscle Contraction 0.999999999994143 -5.85656222697677e-12 38 0 0 21 5310 WP2029 Cell Differentiation - Index 0.999999999994143 -5.85656222697677e-12 38 0 0 21 5310 WP2526 PDGF Pathway 0.999999999994143 -5.85656222697677e-12 38 0 0 21 5310 WP2359 Parkin-Ubiquitin Proteasomal System pathway 0.999999999996424 -3.57596086443106e-12 70 0 0 21 5310 WP428 Wnt Signaling Pathway 0.999999999996424 -3.57596086443106e-12 70 0 0 21 5310 WP2795 Cardiac Hypertrophic Response 0.999999999996995 -3.00460081588599e-12 57 0 0 21 5310 WP195 IL-1 signaling pathway 0.999999999996995 -3.00460081588599e-12 57 0 0 21 5310 WP1423 Ganglio Sphingolipid Metabolism 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP3892 Development of pulmonary dendritic cells and macrophage subsets 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP2881 Estrogen Receptor Pathway 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP1991 SRF and miRs in Smooth Muscle Differentiation and Proliferation 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP3871 Valproic acid pathway 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP1434 Osteopontin Signaling 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP3876 BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP186 Homologous recombination 0.999999999997911 -2.08890575292751e-12 13 0 0 21 5310 WP560 TGF-beta Receptor Signaling 0.999999999998049 -1.95089261865125e-12 58 0 0 21 5310 WP734 Serotonin Receptor 4/6/7 and NR3C Signaling 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP3877 Simplified Depiction of MYD88 Distinct Input-Output Pathway 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP404 Nucleotide Metabolism 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP247 Small Ligand GPCRs 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP3287 Overview of nanoparticle effects 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP384 Apoptosis Modulation by HSP70 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP1992 TarBasePathway 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP22 IL-9 Signaling Pathway 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP697 Estrogen metabolism 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP2879 Farnesoid X Receptor Pathway 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP2011 SREBF and miR33 in cholesterol and lipid homeostasis 0.999999999998348 -1.6520337722487e-12 19 0 0 21 5310 WP2338 miRNA Biogenesis 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP3634 Insulin signalling in human adipocytes (normal condition) 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP2276 Glial Cell Differentiation 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP136 Phase I biotransformations, non P450 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP3655 Hypothetical Craniofacial Development Pathway 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP2485 NAD Biosynthesis II (from tryptophan) 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP3635 Insulin signalling in human adipocytes (diabetic condition) 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP1589 Folate-Alcohol and Cancer Pathway 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP3407 FTO Obesity Variant Mechanism 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP237 Glucocorticoid & Mineralcorticoid Metabolism 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP1604 Codeine and Morphine Metabolism 0.999999999998384 -1.61634487810682e-12 8 0 0 21 5310 WP516 Hypertrophy Model 0.999999999999313 -6.86524484020988e-13 20 0 0 21 5310 WP1742 TP53 Network 0.999999999999313 -6.86524484020988e-13 20 0 0 21 5310 WP732 Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 0.999999999999313 -6.86524484020988e-13 20 0 0 21 5310 WP1422 Sphingolipid Metabolism 0.999999999999313 -6.86524484020988e-13 20 0 0 21 5310 WP497 Urea cycle and metabolism of amino groups 0.999999999999313 -6.86524484020988e-13 20 0 0 21 5310 WP391 Mitochondrial Gene Expression 0.999999999999313 -6.86524484020988e-13 20 0 0 21 5310 WP2249 Metastatic brain tumor 0.999999999999453 -5.46839435261431e-13 28 0 0 21 5310 WP2361 Gastric Cancer Network 1 0.999999999999453 -5.46839435261431e-13 28 0 0 21 5310 WP2203 Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 0.999999999999596 -4.03778601208761e-13 47 0 0 21 5310 WP183 Proteasome Degradation 0.999999999999713 -2.86828913993213e-13 66 0 0 21 5310 WP2374 Oncostatin M Signaling Pathway 0.999999999999713 -2.86828913993213e-13 66 0 0 21 5310 WP3651 Pathways Affected in Adenoid Cystic Carcinoma 0.999999999999713 -2.86828913993213e-13 66 0 0 21 5310 WP2324 AGE/RAGE pathway 0.999999999999713 -2.86828913993213e-13 66 0 0 21 5310 WP3593 miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP2942 DDX1 as a regulatory component of the Drosha microprocessor 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP3674 Tgif disruption of Shh signaling 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP3585 Cytosine methylation 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP561 Heme Biosynthesis 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP3875 ATR Signaling 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP531 Mismatch repair 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP696 Benzo(a)pyrene metabolism 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP3300 Dual hijack model of Vif in HIV infection 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP288 NLR Proteins 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP3297 EV release from cardiac cells and their functional effects 0.999999999999719 -2.81419462979471e-13 9 0 0 21 5310 WP2332 Interleukin-11 Signaling Pathway 1.00000000000062 6.17504724138216e-13 44 0 0 21 5310 WP716 Vitamin A and Carotenoid Metabolism 1.00000000000062 6.17504724138216e-13 44 0 0 21 5310 WP314 Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation 1.00000000000062 6.17504724138216e-13 44 0 0 21 5310 WP138 Androgen receptor signaling pathway 1.00000000000093 9.31327645373736e-13 90 0 0 21 5310 WP477 Cytoplasmic Ribosomal Proteins 1.00000000000093 9.31327645373736e-13 90 0 0 21 5310 WP3845 Canonical and Non-canonical Notch signaling 1.00000000000096 9.58581556254777e-13 27 0 0 21 5310 WP2035 Follicle Stimulating Hormone (FSH) signaling pathway 1.00000000000096 9.58581556254777e-13 27 0 0 21 5310 WP1133 Androgen receptor signaling pathway 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP3633 Caffeine and Theobromine metabolism 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP733 Serotonin Receptor 2 and STAT3 Signaling 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP2889 Oxytocin signaling 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP521 Amino acid conjugation of benzoic acid 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP897 Androgen receptor signaling pathway 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP3302 eIF5A regulation in response to inhibition of the nuclear export system 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP2491 Diclofenac Metabolic Pathway 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP690 Polyol Pathway 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP1603 Nicotine Activity on Chromaffin Cells 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP1941 Peroxisomal beta-oxidation of tetracosanoyl-CoA 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP2253 Pilocytic astrocytoma 1.00000000000126 1.26429370124202e-12 4 0 0 21 5310 WP2018 RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway 1.00000000000206 2.05727276050022e-12 55 0 0 21 5310 WP2272 Pathogenic Escherichia coli infection 1.00000000000206 2.05727276050022e-12 55 0 0 21 5310 WP395 IL-4 Signaling Pathway 1.00000000000206 2.05727276050022e-12 55 0 0 21 5310 WP585 Interferon type I signaling pathways 1.00000000000206 2.05727276050022e-12 55 0 0 21 5310 WP707 DNA Damage Response 1.00000000000229 2.2864035514037e-12 69 0 0 21 5310 WP2369 Histone Modifications 1.00000000000229 2.2864035514037e-12 69 0 0 21 5310 WP176 Folate Metabolism 1.00000000000229 2.2864035514037e-12 69 0 0 21 5310 WP1531 Vitamin D Metabolism 1.00000000000253 2.53278511002438e-12 10 0 0 21 5310 WP496 Steroid Biosynthesis 1.00000000000253 2.53278511002438e-12 10 0 0 21 5310 WP704 Methylation Pathways 1.00000000000253 2.53278511002438e-12 10 0 0 21 5310 WP2333 Trans-sulfuration pathway 1.00000000000253 2.53278511002438e-12 10 0 0 21 5310 WP2874 Liver X Receptor Pathway 1.00000000000253 2.53278511002438e-12 10 0 0 21 5310 WP2113 Type III interferon signaling 1.00000000000253 2.53278511002438e-12 10 0 0 21 5310 WP3656 Interleukin-1 Induced Activation of NF-kappa-B 1.00000000000253 2.53278511002438e-12 10 0 0 21 5310 WP3657 Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP3599 Transcription factor regulation in adipogenesis 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP1424 Globo Sphingolipid Metabolism 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP100 Glutathione metabolism 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP3872 Regulation of Apoptosis by Parathyroid Hormone-related Protein 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP3645 NAD+ biosynthetic pathways 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP167 Eicosanoid Synthesis 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP357 Fatty Acid Biosynthesis 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP1584 Type II diabetes mellitus 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP272 Blood Clotting Cascade 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP545 Complement Activation 1.00000000000265 2.6511247598441e-12 22 0 0 21 5310 WP254 Apoptosis 1.00000000000279 2.78889288950213e-12 86 0 0 21 5310 WP111 Electron Transport Chain 1.00000000000297 2.97025401446828e-12 92 0 0 21 5310 WP43 Oxidation by Cytochrome P450 1.00000000000298 2.97852702292198e-12 63 0 0 21 5310 WP3624 Lung fibrosis 1.00000000000298 2.97852702292198e-12 63 0 0 21 5310 WP2012 miRs in Muscle Cell Differentiation 1.000000000003 2.99861252370388e-12 36 0 0 21 5310 WP500 Glycogen Metabolism 1.000000000003 2.99861252370388e-12 36 0 0 21 5310 WP2406 Cardiac Progenitor Differentiation 1.00000000000321 3.21308777293078e-12 53 0 0 21 5310 WP363 Wnt Signaling Pathway Netpath 1.00000000000321 3.21308777293078e-12 53 0 0 21 5310 WP107 Translation Factors 1.00000000000321 3.21308777293078e-12 53 0 0 21 5310 WP262 EBV LMP1 signaling 1.00000000000341 3.41180106156653e-12 24 0 0 21 5310 WP1539 Angiogenesis 1.00000000000341 3.41180106156653e-12 24 0 0 21 5310 WP334 GPCRs, Class B Secretin-like 1.00000000000341 3.41180106156653e-12 24 0 0 21 5310 WP2509 Nanoparticle triggered autophagic cell death 1.00000000000341 3.41180106156653e-12 24 0 0 21 5310 WP3658 Wnt/beta-catenin Signaling Pathway in Leukemia 1.00000000000341 3.41180106156653e-12 24 0 0 21 5310 WP1433 Nucleotide-binding Oligomerization Domain (NOD) pathway 1.00000000000347 3.47379969972991e-12 41 0 0 21 5310 WP710 DNA Damage Response (only ATM dependent) 1.00000000000362 3.62162708781238e-12 114 0 0 21 5310 WP2636 Common Pathways Underlying Drug Addiction 1.00000000000383 3.83059138748714e-12 42 0 0 21 5310 WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway 1.00000000000383 3.83059138748714e-12 42 0 0 21 5310 WP49 IL-2 Signaling Pathway 1.00000000000383 3.83059138748714e-12 42 0 0 21 5310 WP466 DNA Replication 1.00000000000383 3.83059138748714e-12 42 0 0 21 5310 WP405 Eukaryotic Transcription Initiation 1.00000000000383 3.83059138748714e-12 42 0 0 21 5310 WP2646 Lidocaine metabolism 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP2816 Felbamate Metabolism 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP2866 mir34a and TGIF2 in osteoclastogenesis 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP2901 Gonadotropin-releasing hormone (GnRH) signaling 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP1273 Folic Acid Network 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP1311 Folic Acid Network 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP2366 Butyrate-induced histone acetylation 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP2943 Hypoxia-mediated EMT and Stemness 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP1438 Influenza A virus infection 1.00000000000485 4.8455479859528e-12 2 0 0 21 5310 WP26 Signal Transduction of S1P Receptor 1.00000000000519 5.19439950350572e-12 26 0 0 21 5310 WP325 Triacylglyceride Synthesis 1.00000000000519 5.19439950350572e-12 26 0 0 21 5310 WP530 Cytokines and Inflammatory Response 1.00000000000519 5.19439950350572e-12 26 0 0 21 5310 WP581 EPO Receptor Signaling 1.00000000000519 5.19439950350572e-12 26 0 0 21 5310 WP698 Glucuronidation 1.00000000000519 5.19439950350572e-12 26 0 0 21 5310 WP2878 PPAR Alpha Pathway 1.00000000000519 5.19439950350572e-12 26 0 0 21 5310 WP3851 TLR4 Signaling and Tolerance 1.00000000000527 5.27144242343361e-12 30 0 0 21 5310 WP98 Prostaglandin Synthesis and Regulation 1.00000000000527 5.27144242343361e-12 30 0 0 21 5310 WP129 Matrix Metalloproteinases 1.00000000000527 5.27144242343361e-12 30 0 0 21 5310 WP2870 Extracellular vesicle-mediated signaling in recipient cells 1.00000000000527 5.27144242343361e-12 30 0 0 21 5310 WP3844 PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1.00000000000527 5.27144242343361e-12 30 0 0 21 5310 WP241 One Carbon Metabolism 1.00000000000527 5.27144242343361e-12 30 0 0 21 5310 WP2855 Dopaminergic Neurogenesis 1.00000000000527 5.27144242343361e-12 30 0 0 21 5310 WP382 MAPK Signaling Pathway 1.00000000000539 5.39120682991675e-12 170 0 0 21 5310 WP2290 RalA downstream regulated genes 1.00000000000558 5.57579373529167e-12 12 0 0 21 5310 WP2007 Iron metabolism in placenta 1.00000000000558 5.57579373529167e-12 12 0 0 21 5310 WP106 Alanine and aspartate metabolism 1.00000000000558 5.57579373529167e-12 12 0 0 21 5310 WP1559 TFs Regulate miRNAs related to cardiac hypertrophy 1.00000000000558 5.57579373529167e-12 12 0 0 21 5310 WP3849 MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ 1.00000000000558 5.57579373529167e-12 12 0 0 21 5310 WP3672 LncRNA-mediated mechanisms of therapeutic resistance 1.00000000000558 5.57579373529167e-12 12 0 0 21 5310 WP3859 TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition 1.00000000000573 5.73030014251474e-12 18 0 0 21 5310 WP3879 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression 1.00000000000573 5.73030014251474e-12 18 0 0 21 5310 WP3664 Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds 1.00000000000573 5.73030014251474e-12 18 0 0 21 5310 WP692 Sulfation Biotransformation Reaction 1.00000000000573 5.73030014251474e-12 18 0 0 21 5310 WP47 Hedgehog Signaling Pathway 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP550 Biogenic Amine Synthesis 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP2453 TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP501 GPCRs, Class C Metabotropic glutamate, pheromone 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP53 ID signaling pathway 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP12 Osteoclast Signaling 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP2291 Deregulation of Rab and Rab Effector Genes in Bladder Cancer 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP3644 NAD+ metabolism 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP1946 Cori Cycle 1.00000000000605 6.05249083161493e-12 16 0 0 21 5310 WP299 Nuclear Receptors in Lipid Metabolism and Toxicity 1.00000000000625 6.24944644651114e-12 35 0 0 21 5310 WP244 Alpha 6 Beta 4 signaling pathway 1.00000000000625 6.24944644651114e-12 35 0 0 21 5310 WP3617 Photodynamic therapy-induced NF-kB survival signaling 1.00000000000625 6.24944644651114e-12 35 0 0 21 5310 WP453 Inflammatory Response Pathway 1.00000000000629 6.28836889551295e-12 33 0 0 21 5310 WP2197 Endothelin Pathways 1.00000000000629 6.28836889551295e-12 33 0 0 21 5310 WP2363 Gastric Cancer Network 2 1.00000000000629 6.28836889551295e-12 33 0 0 21 5310 WP58 Monoamine GPCRs 1.00000000000629 6.28836889551295e-12 33 0 0 21 5310 WP2328 Allograft Rejection 1.0000000000063 6.30359463792397e-12 80 0 0 21 5310 WP2516 ATM Signaling Pathway 1.00000000000639 6.38917401838961e-12 40 0 0 21 5310 WP524 G13 Signaling Pathway 1.00000000000639 6.38917401838961e-12 40 0 0 21 5310 WP127 IL-5 Signaling Pathway 1.00000000000639 6.38917401838961e-12 40 0 0 21 5310 WP2868 TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer 1.00000000000647 6.47275695733317e-12 5 0 0 21 5310 WP311 Synthesis and Degradation of Ketone Bodies 1.00000000000647 6.47275695733317e-12 5 0 0 21 5310 WP3596 miR-517 relationship with ARCN1 and USP1 1.00000000000647 6.47275695733317e-12 5 0 0 21 5310 WP2542 Sulindac Metabolic Pathway 1.00000000000647 6.47275695733317e-12 5 0 0 21 5310 WP688 Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs) 1.00000000000647 6.47275695733317e-12 5 0 0 21 5310 WP2597 Secretion of Hydrochloric Acid in Parietal Cells 1.00000000000647 6.47275695733317e-12 5 0 0 21 5310 WP2637 Structural Pathway of Interleukin 1 (IL-1) 1.00000000000658 6.58123048989099e-12 50 0 0 21 5310 WP1545 miRNAs involved in DNA damage response 1.00000000000658 6.58123048989099e-12 50 0 0 21 5310 WP179 Cell Cycle 1.00000000000668 6.67779505558811e-12 105 0 0 21 5310 WP623 Oxidative phosphorylation 1.00000000000695 6.94643282901944e-12 54 0 0 21 5310 WP3286 Copper homeostasis 1.00000000000695 6.94643282901944e-12 54 0 0 21 5310 WP455 GPCRs, Class A Rhodopsin-like 1.00000000000706 7.06330968002961e-12 259 0 0 21 5310 WP3408 Evolocumab Mechanism 1.00000000000742 7.41764548335525e-12 3 0 0 21 5310 WP2846 Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation 1.00000000000742 7.41764548335525e-12 3 0 0 21 5310 WP2643 Nanoparticle-mediated activation of receptor signaling 1.0000000000075 7.50276698021933e-12 29 0 0 21 5310 WP422 MAPK Cascade 1.0000000000075 7.50276698021933e-12 29 0 0 21 5310 WP2583 T-Cell Receptor and Co-stimulatory Signaling 1.0000000000075 7.50276698021933e-12 29 0 0 21 5310 WP3613 Photodynamic therapy-induced unfolded protein response 1.0000000000075 7.50276698021933e-12 29 0 0 21 5310 WP69 T-Cell antigen Receptor (TCR) Signaling Pathway 1.00000000000752 7.52342559754148e-12 91 0 0 21 5310 WP143 Fatty Acid Beta Oxidation 1.00000000000756 7.55611106289462e-12 34 0 0 21 5310 WP400 p38 MAPK Signaling Pathway 1.00000000000756 7.55611106289462e-12 34 0 0 21 5310 WP313 Signaling of Hepatocyte Growth Factor Receptor 1.00000000000756 7.55611106289462e-12 34 0 0 21 5310 WP1601 Fluoropyrimidine Activity 1.00000000000756 7.55611106289462e-12 34 0 0 21 5310 WP322 Osteoblast Signaling 1.00000000000764 7.63495974575998e-12 14 0 0 21 5310 WP2436 Dopamine metabolism 1.00000000000764 7.63495974575998e-12 14 0 0 21 5310 WP229 Irinotecan Pathway 1.00000000000764 7.63495974575998e-12 14 0 0 21 5310 WP1591 Heart Development 1.00000000000783 7.82650502530563e-12 46 0 0 21 5310 WP268 Notch Signaling Pathway 1.00000000000783 7.82650502530563e-12 46 0 0 21 5310 WP28 Selenium Metabolism and Selenoproteins 1.00000000000783 7.82650502530563e-12 46 0 0 21 5310 WP1971 Integrated Cancer Pathway 1.00000000000783 7.82650502530563e-12 46 0 0 21 5310 WP3878 ATM Signaling Network in Development and Disease 1.00000000000783 7.82650502530563e-12 46 0 0 21 5310 WP465 Tryptophan metabolism 1.00000000000783 7.82650502530563e-12 46 0 0 21 5310 WP2371 Parkinsons Disease Pathway 1.00000000000804 8.044659067058e-12 83 0 0 21 5310 WP2261 Signaling Pathways in Glioblastoma 1.00000000000804 8.044659067058e-12 83 0 0 21 5310 WP23 B Cell Receptor Signaling Pathway 1.00000000000873 8.73286820271686e-12 98 0 0 21 5310 WP3627 Gut-Liver Indole Metabolism 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP661 Glucose Homeostasis 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP3191 TSLP Signaling Pathway 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP1 Statin Pathway 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP2190 One carbon donor 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP108 Selenium metabolism/Selenoproteins 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP2536 Colchicine Metabolic Pathway 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP188 Focal Adhesion 1.00000000000922 9.21925036312388e-12 1 0 0 21 5310 WP205 IL-7 Signaling Pathway 1.00000000000938 9.37745300278831e-12 25 0 0 21 5310 WP2895 Differentiation of white and brown adipocyte 1.00000000000938 9.37745300278831e-12 25 0 0 21 5310 WP2865 IL1 and megakaryocytes in obesity 1.00000000000938 9.37745300278831e-12 25 0 0 21 5310 WP3668 Hypothesized Pathways in Pathogenesis of Cardiovascular Disease 1.00000000000938 9.37745300278831e-12 25 0 0 21 5310 WP1528 Physiological and Pathological Hypertrophy of the Heart 1.00000000000938 9.37745300278831e-12 25 0 0 21 5310 WP2884 NRF2 pathway 1.00000000000938 9.38048563072207e-12 143 0 0 21 5310 WP364 IL-6 signaling pathway 1.00000000000953 9.53142062132579e-12 43 0 0 21 5310 WP1403 AMP-activated Protein Kinase (AMPK) Signaling 1.00000000000958 9.57981239958143e-12 68 0 0 21 5310 WP3680 Association Between Physico-Chemical Features and Toxicity Associated Pathways 1.00000000000958 9.57981239958143e-12 68 0 0 21 5310 WP3303 Rac1/Pak1/p38/MMP-2 pathway 1.00000000000958 9.57981239958143e-12 68 0 0 21 5310 WP45 G1 to S cell cycle control 1.00000000000958 9.57981239958143e-12 68 0 0 21 5310 WP2032 Human Thyroid Stimulating Hormone (TSH) signaling pathway 1.00000000000958 9.57981239958143e-12 68 0 0 21 5310 WP35 G Protein Signaling Pathways 1.00000000000964 9.64380544700933e-12 95 0 0 21 5310 WP117 GPCRs, Other 1.00000000000964 9.64380544700933e-12 95 0 0 21 5310 WP1602 Nicotine Activity on Dopaminergic Neurons 1.00000000000981 9.80633207140768e-12 21 0 0 21 5310 WP2533 Glycerophospholipid Biosynthetic Pathway 1.00000000000981 9.80633207140768e-12 21 0 0 21 5310 WP3670 Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway 1.00000000000981 9.80633207140768e-12 21 0 0 21 5310 WP2507 Nanomaterial induced apoptosis 1.00000000000981 9.80633207140768e-12 21 0 0 21 5310 WP691 Tamoxifen metabolism 1.00000000000981 9.80633207140768e-12 21 0 0 21 5310 WP2446 Retinoblastoma (RB) in Cancer 1.00000000000992 9.92194030874822e-12 88 0 0 21 5310 WP2034 Leptin signaling pathway 1.00000000001008 1.0081190751214e-11 76 0 0 21 5310 WP2037 Prolactin Signaling Pathway 1.00000000001008 1.0081190751214e-11 76 0 0 21 5310 WP2355 Corticotropin-releasing hormone signaling pathway 1.00000000001022 1.02192824694761e-11 93 0 0 21 5310 WP1530 miRNA Regulation of DNA Damage Response 1.00000000001022 1.02192824694761e-11 93 0 0 21 5310 WP2875 Constitutive Androstane Receptor Pathway 1.00000000001026 1.02562050190384e-11 32 0 0 21 5310 WP727 Monoamine Transport 1.00000000001026 1.02562050190384e-11 32 0 0 21 5310 WP3858 Toll-like Receptor Signaling 1.00000000001026 1.02562050190384e-11 32 0 0 21 5310 WP2525 Trans-sulfuration and one carbon metabolism 1.00000000001026 1.02562050190384e-11 32 0 0 21 5310 WP24 Peptide GPCRs 1.00000000001039 1.0386831741304e-11 74 0 0 21 5310 WP2572 Primary Focal Segmental Glomerulosclerosis FSGS 1.00000000001039 1.0386831741304e-11 74 0 0 21 5310 WP2112 IL17 signaling pathway 1.00000000001062 1.06170850287641e-11 31 0 0 21 5310 WP3850 Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling 1.00000000001062 1.06170850287641e-11 31 0 0 21 5310 WP408 Oxidative Stress 1.00000000001062 1.06170850287641e-11 31 0 0 21 5310 WP399 Wnt Signaling Pathway and Pluripotency 1.00000000001091 1.09106197815669e-11 106 0 0 21 5310 WP615 Senescence and Autophagy in Cancer 1.00000000001091 1.09106197815669e-11 106 0 0 21 5310 WP2848 Differentiation Pathway 1.00000000001104 1.10422549659905e-11 48 0 0 21 5310 WP2586 Aryl Hydrocarbon Receptor 1.00000000001104 1.10422549659905e-11 48 0 0 21 5310 WP2873 Aryl Hydrocarbon Receptor Pathway 1.00000000001104 1.10422549659905e-11 48 0 0 21 5310 WP2849 Hematopoietic Stem Cell Differentiation 1.00000000001104 1.10422549659905e-11 48 0 0 21 5310 WP3865 RIG-I-like Receptor Signaling 1.0000000000113 1.13026476916217e-11 61 0 0 21 5310 WP3527 Preimplantation Embryo 1.00000000001142 1.14160650234937e-11 60 0 0 21 5310 WP304 Kit receptor signaling pathway 1.00000000001142 1.14160650234937e-11 60 0 0 21 5310 WP702 Metapathway biotransformation 1.0000000000117 1.16988330743542e-11 177 0 0 21 5310 WP437 EGF/EGFR Signaling Pathway 1.00000000001216 1.21649622994036e-11 162 0 0 21 5310 WP61 Notch Signaling Pathway 1.00000000001246 1.24555300816731e-11 62 0 0 21 5310 WP3863 T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection 1.00000000001246 1.24555300816731e-11 62 0 0 21 5310 WP3584 MECP2 and Associated Rett Syndrome 1.00000000001246 1.24555300816731e-11 62 0 0 21 5310 WP3612 Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling 1.00000000001295 1.29455683478713e-11 23 0 0 21 5310 WP712 Estrogen signaling pathway 1.00000000001295 1.29455683478713e-11 23 0 0 21 5310 WP2853 Endoderm Differentiation 1.00000000001297 1.29664596096578e-11 145 0 0 21 5310 WP1449 Regulation of toll-like receptor signaling pathway 1.00000000001297 1.29664596096578e-11 145 0 0 21 5310 WP3646 Hepatitis C and Hepatocellular Carcinoma 1.00000000001302 1.30190227297857e-11 51 0 0 21 5310 WP3611 Photodynamic therapy-induced AP-1 survival signaling. 1.00000000001302 1.30190227297857e-11 51 0 0 21 5310 WP3924 Hfe effect on hepcidin production 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP528 Acetylcholine Synthesis 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP1995 Effects of Nitric Oxide 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP699 Aflatoxin B1 metabolism 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP2596 Gastric acid production 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP2805 RNA interference 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP134 Pentose Phosphate Pathway 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP1272 Selenium Micronutrient Network 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP438 Non-homologous end joining 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP678 Arachidonate Epoxygenase / Epoxide Hydrolase 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP3595 mir-124 predicted interactions with cell cycle and differentiation 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP1310 Selenium Micronutrient Network 1.00000000001305 1.30527770810187e-11 7 0 0 21 5310 WP3414 Initiation of transcription and translation elongation at the HIV-1 LTR 1.00000000001306 1.30556050851378e-11 37 0 0 21 5310 WP1471 Target Of Rapamycin (TOR) Signaling 1.00000000001306 1.30556050851378e-11 37 0 0 21 5310 WP3529 Zinc homeostasis 1.00000000001306 1.30556050851378e-11 37 0 0 21 5310 WP619 Type II interferon signaling (IFNG) 1.00000000001306 1.30556050851378e-11 37 0 0 21 5310 WP3614 Photodynamic therapy-induced HIF-1 survival signaling 1.00000000001306 1.30556050851378e-11 37 0 0 21 5310 WP231 TNF alpha Signaling Pathway 1.00000000001348 1.34767241981992e-11 94 0 0 21 5310 WP1772 Apoptosis Modulation and Signaling 1.00000000001348 1.34767241981992e-11 94 0 0 21 5310 WP75 Toll-like Receptor Signaling Pathway 1.00000000001361 1.36147015684755e-11 103 0 0 21 5310 WP2854 Gene regulatory network modelling somitogenesis 1.00000000001423 1.42291263003514e-11 11 0 0 21 5310 WP3630 NAD metabolism, sirtuins and aging 1.00000000001423 1.42291263003514e-11 11 0 0 21 5310 WP80 Nucleotide GPCRs 1.00000000001423 1.42291263003514e-11 11 0 0 21 5310 WP1455 Serotonin Transporter Activity 1.00000000001423 1.42291263003514e-11 11 0 0 21 5310 WP2513 Nanoparticle triggered regulated necrosis 1.00000000001423 1.42291263003514e-11 11 0 0 21 5310 WP1544 MicroRNAs in cardiomyocyte hypertrophy 1.00000000001443 1.44250329421243e-11 102 0 0 21 5310 WP411 mRNA Processing 1.00000000001487 1.48733319718822e-11 132 0 0 21 5310 WP3915 Angiopoietin Like Protein 8 Regulatory Pathway 1.00000000001487 1.48733319718822e-11 132 0 0 21 5310 WP366 TGF-beta Signaling Pathway 1.00000000001497 1.49706280399909e-11 133 0 0 21 5310 WP694 Arylamine metabolism 1.00000000001567 1.56683761420327e-11 6 0 0 21 5310 WP1981 Thyroxine (Thyroid Hormone) Production 1.00000000001567 1.56683761420327e-11 6 0 0 21 5310 WP1600 Nicotine Metabolism 1.00000000001567 1.56683761420327e-11 6 0 0 21 5310 WP3891 Benzene metabolism 1.00000000001567 1.56683761420327e-11 6 0 0 21 5310 WP78 TCA Cycle 1.0000000000159 1.58959378683322e-11 17 0 0 21 5310 WP2916 Interactome of polycomb repressive complex 2 (PRC2) 1.0000000000159 1.58959378683322e-11 17 0 0 21 5310 WP3678 Amplification and Expansion of Oncogenic Pathways as Metastatic Traits 1.0000000000159 1.58959378683322e-11 17 0 0 21 5310 WP368 Mitochondrial LC-Fatty Acid Beta-Oxidation 1.0000000000159 1.58959378683322e-11 17 0 0 21 5310 WP3874 Canonical and Non-Canonical TGF-B signaling 1.0000000000159 1.58959378683322e-11 17 0 0 21 5310 WP554 ACE Inhibitor Pathway 1.0000000000159 1.58959378683322e-11 17 0 0 21 5310 WP2289 Drug Induction of Bile Acid Pathway 1.0000000000159 1.58959378683322e-11 17 0 0 21 5310 WP1984 Integrated Breast Cancer Pathway 1.00000000001733 1.73340290749758e-11 154 0 0 21 5310 WP15 Selenium Micronutrient Network 1.00000000001903 1.90255050272415e-11 87 0 0 21 5310 WP3 Transcriptional activation by NRF2 1.00000000001914 1.91422770757989e-11 15 0 0 21 5310 WP197 Cholesterol Biosynthesis 1.00000000001914 1.91422770757989e-11 15 0 0 21 5310 WP206 Fatty Acid Omega Oxidation 1.00000000001914 1.91422770757989e-11 15 0 0 21 5310 WP2435 Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis 1.00000000001914 1.91422770757989e-11 15 0 0 21 5310 WP410 Diurnally Regulated Genes with Circadian Orthologs 1.00000000002046 2.04555986893409e-11 49 0 0 21 5310 WP286 IL-3 Signaling Pathway 1.00000000002046 2.04555986893409e-11 49 0 0 21 5310 WP534 Glycolysis and Gluconeogenesis 1.00000000002046 2.04555986893409e-11 49 0 0 21 5310