Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.355e-17	-38.84	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	28	16828	48	STXBP5L,CNTN5,ANK2,NRG1,RALYL,SLC35F3,CNTNAP2,NRG3,EBF1,FSTL5,TLL1,GRIA4,ZNF385B,RIMS1,GPC6,GRID2,CADPS2,NRXN3,LSAMP,SYT1,UNC5C,EPHA5,CHN2,CACNA2D1,SLC1A3,PTPRG,ST18,PCDH9
1.355e-17	-38.84	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	28	16828	48	FSTL5,EBF1,TLL1,GRIA4,NRG3,CNTNAP2,SLC35F3,NRG1,RALYL,CNTN5,STXBP5L,ANK2,PCDH9,ST18,PTPRG,EPHA5,SLC1A3,CACNA2D1,CHN2,CADPS2,GRID2,SYT1,LSAMP,UNC5C,NRXN3,GPC6,RIMS1,ZNF385B
1.442e-17	-38.78	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	19	16828	48	FSTL5,PCDH9,GRIA4,TLL1,EPHA5,MYT1L,NRG3,CACNA2D1,TRPM3,GRID2,CNTNAP2,SLC35F3,LSAMP,RALYL,NRXN3,ZNF385D,ANK2,RIMS1,GPC6
5.017e-17	-37.53	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	31	16828	48	RIMS1,GPC6,ZNF385B,RELN,SYT1,LSAMP,UNC5C,NRXN3,KIF21A,CADPS2,GRID2,SLC1A3,CACNA2D1,CHN2,NPAS3,EPHA5,PCDH9,PTPRG,ZNF385D,ANK2,KCNJ3,STXBP5L,CNTNAP2,SLC35F3,NRG1,RALYL,NRG3,TLL1,GRIA4,FSTL5,EBF1
5.017e-17	-37.53	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	31	16828	48	ANK2,ZNF385D,KCNJ3,STXBP5L,CNTNAP2,SLC35F3,NRG1,RALYL,NRG3,TLL1,GRIA4,EBF1,FSTL5,RIMS1,GPC6,ZNF385B,RELN,SYT1,LSAMP,UNC5C,NRXN3,KIF21A,CADPS2,GRID2,SLC1A3,CACNA2D1,CHN2,NPAS3,EPHA5,PCDH9,PTPRG
2.026e-16	-36.14	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	34	16828	48	SLC1A3,CACNA2D1,CHN2,EPHA5,PCDH9,PTPRG,RIMS1,GPC6,ZNF385B,RELN,CNTN4,UNC5C,SYT1,LSAMP,NRXN3,CADPS2,GRID2,NRG3,MYT1L,TRPM3,RIMS2,GRIA4,TLL1,FSTL5,EBF1,ANK2,ZNF385D,KCNJ3,LRRTM4,STXBP5L,SLC35F3,CNTNAP2,RALYL,NRG1
2.530e-16	-35.91	lymph_node	COSMIC cancer mutations	lymph_node	1703	28	16828	48	EPHA5,CACNA2D1,SLC1A3,PCDH9,RELN,GPC6,RIMS1,CDH18,KIF21A,GRID2,LSAMP,NRXN3,DTNA,RIMS2,MYT1L,NRG3,TRPM3,EBF1,FSTL5,GRIA4,TLL1,GRIK2,ANK2,ZNF385D,KCNJ3,SLC35F3,CNTNAP2,RALYL
6.812e-16	-34.92	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	33	16828	48	NRG1,RALYL,CNTNAP2,SLC35F3,KCNJ3,ZNF385D,ANK2,STXBP5L,LRRTM4,TLL1,GRIA4,FSTL5,EBF1,MYT1L,NRG3,RIMS2,NRXN3,LSAMP,SYT1,UNC5C,GRID2,CADPS2,ZNF385B,RIMS1,GPC6,CNTN4,RELN,PTPRG,PCDH9,CHN2,CACNA2D1,SLC1A3,EPHA5
4.453e-14	-30.74	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	17	16828	48	NRG3,CHN2,EPHA5,PCDH9,PTPRG,GRIA4,ST18,FSTL5,GPC6,RIMS1,ZNF385B,KCNJ3,SYT1,LSAMP,CNTNAP2,NRXN3,GRID2
7.773e-14	-30.19	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	18	16828	48	ZNF385B,ANK2,ZNF385D,GPC6,GRID2,NRXN3,RALYL,NRG1,CNTNAP2,SLC35F3,NRXN1,EPHA5,NPAS3,CHN2,NRG3,MYT1L,GRIA4,PCDH9
7.979e-14	-30.16	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	18	16828	48	PCDH9,GRIA4,NRG3,MYT1L,CHN2,EPHA5,NPAS3,NRXN1,CNTNAP2,SLC35F3,RALYL,NRXN3,NRG1,GRID2,ZNF385D,ANK2,GPC6,ZNF385B
8.157e-14	-30.14	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	19	16828	48	PCDH9,PTPRG,FSTL5,EBF1,NRG3,EPHA5,LSAMP,SYT1,UNC5C,SLC35F3,CNTNAP2,RALYL,CADPS2,GRID2,GPC6,RIMS1,ZNF385B,RELN,STXBP5L
9.168e-14	-30.02	cerebellum	COSMIC cancer mutations	cerebellum	769	19	16828	48	GRID2,NRXN3,RALYL,NRG1,SLC35F3,CNTNAP2,ZNF385B,ANK2,ZNF385D,GPC6,FSTL5,GRIA4,PCDH9,NRXN1,EPHA5,NPAS3,CHN2,MYT1L,NRG3
1.662e-13	-29.43	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	28	16828	48	RELN,ZNF385B,GPC6,RIMS1,GRID2,CADPS2,KIF21A,NRXN3,UNC5C,LSAMP,EPHA5,SLC1A3,CACNA2D1,PTPRG,ST18,PCDH9,STXBP5L,ZNF385D,ANK2,RALYL,SLC35F3,CNTNAP2,RIMS2,NRG3,FSTL5,EBF1,GRIA4,TLL1
1.662e-13	-29.43	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	28	16828	48	ANK2,ZNF385D,STXBP5L,RALYL,SLC35F3,CNTNAP2,NRG3,RIMS2,TLL1,GRIA4,FSTL5,EBF1,ZNF385B,GPC6,RIMS1,RELN,NRXN3,LSAMP,UNC5C,GRID2,KIF21A,CADPS2,SLC1A3,CACNA2D1,EPHA5,ST18,PTPRG,PCDH9
2.068e-13	-29.21	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	28	16828	48	STXBP5L,ANK2,ZNF385D,SLC35F3,CNTNAP2,RALYL,RIMS2,NRG3,FSTL5,EBF1,TLL1,GRIA4,RELN,RIMS1,GPC6,ZNF385B,KIF21A,CADPS2,GRID2,LSAMP,UNC5C,NRXN3,EPHA5,CACNA2D1,SLC1A3,PCDH9,ST18,PTPRG
2.581e-13	-28.99	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	22	16828	48	NRG1,CNTNAP2,KCNJ3,ZNF385D,FSTL5,EBF1,GRIA4,RIMS2,NRG3,GRID2,NRXN3,LSAMP,SYT1,UNC5C,CNTN4,RELN,GPC6,PTPRG,PCDH9,EPHA5,CHN2,CACNA2D1
6.558e-13	-28.05	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	23	16828	48	UNC5C,NRXN3,CADPS2,GRID2,GPC6,RIMS1,ZNF385B,RELN,ST18,PTPRG,CACNA2D1,CHN2,EPHA5,CNTNAP2,ANK2,ZNF385D,KCNJ3,STXBP5L,TLL1,FSTL5,EBF1,NRG3,TRPM3
1.088e-12	-27.55	synapse	cellular component	GO:0045202	1473	22	19108	48	SYT1,KCNJ3,NRG3,GPC6,UNC5C,CADPS2,APOE,RIMS1,NRXN3,GRIK2,DTNA,LRRTM4,CNTN4,CHN2,GRIA4,RIMS2,NRXN1,GRID2,CNTN5,CNTNAP2,SLC1A3,ANK2
1.843e-12	-27.02	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	34	16828	48	CHN2,CACNA2D1,SLC1A3,NRXN1,EPHA5,PTPRG,NFIA,PCDH9,ZNF385B,RIMS1,GPC6,RELN,NRXN3,SYT1,LSAMP,UNC5C,GRID2,KIF21A,CADPS2,CDH18,NRG3,RIMS2,TLL1,GRIA4,FSTL5,EBF1,KCNJ3,ANK2,ZNF385D,CNTN5,LRRTM4,NRG1,SLC35F3,CNTNAP2
1.843e-12	-27.02	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	34	16828	48	TLL1,GRIA4,EBF1,FSTL5,NRG3,RIMS2,SLC35F3,CNTNAP2,NRG1,ANK2,ZNF385D,KCNJ3,CNTN5,LRRTM4,PCDH9,PTPRG,NFIA,CACNA2D1,SLC1A3,CHN2,EPHA5,NRXN1,LSAMP,SYT1,UNC5C,NRXN3,KIF21A,CADPS2,CDH18,GRID2,GPC6,RIMS1,ZNF385B,RELN
3.822e-12	-26.29	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	23	16828	48	GPC6,RIMS1,ZNF385B,RELN,UNC5C,NRXN3,CADPS2,GRID2,CACNA2D1,CHN2,EPHA5,ST18,PTPRG,ANK2,ZNF385D,KCNJ3,STXBP5L,CNTNAP2,NRG3,TRPM3,TLL1,EBF1,FSTL5
6.831e-12	-25.71	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	19	16828	48	CNTN4,KCNJ3,GPC6,ZNF385D,GRID2,NRG1,NRXN3,LSAMP,SYT1,CNTNAP2,UNC5C,EPHA5,CHN2,NRG3,CACNA2D1,FSTL5,PTPRG,GRIA4,PCDH9
8.237e-12	-25.52	cell junction	cellular component	GO:0030054	2224	25	19108	48	GRIA4,CHN2,CNTN4,RIMS2,LRRTM4,DTNA,CDH18,GRIK2,CNTN5,ANK2,SLC1A3,CNTNAP2,GRID2,PCDH9,NRXN1,GPC6,NRG3,UNC5C,KCNJ3,SYT1,NFIA,APOE,NRXN3,RIMS1,CADPS2
1.213e-11	-25.13	synaptic membrane	cellular component	GO:0097060	400	13	19108	48	GRIA4,RIMS2,LRRTM4,SYT1,GRIK2,KCNJ3,CNTN5,ANK2,NRXN3,CNTNAP2,RIMS1,NRXN1,GRID2
1.829e-11	-24.72	brainstem	COSMIC cancer mutations	brainstem	3102	30	16828	48	ANK2,KCNJ3,CNTN5,CNTNAP2,SLC35F3,NRG1,NRG3,TLL1,GRIA4,FSTL5,EBF1,RIMS1,GPC6,ZNF385B,RELN,LSAMP,SYT1,UNC5C,NRXN3,KIF21A,CDH18,CADPS2,GRID2,SLC1A3,CACNA2D1,CHN2,NPAS3,EPHA5,PCDH9,PTPRG
3.380e-11	-24.11	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	12	16828	48	FSTL5,GRIA4,ST18,EPHA5,CHN2,GRID2,CNTNAP2,NRXN3,GPC6,RIMS1,ZNF385B,KCNJ3
4.686e-11	-23.78	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	27	16828	48	GRIA4,TLL1,FSTL5,EBF1,NRG3,CNTNAP2,SLC35F3,NRG1,ANK2,KCNJ3,PCDH9,PTPRG,SLC1A3,CACNA2D1,CHN2,EPHA5,UNC5C,SYT1,LSAMP,NRXN3,CADPS2,KIF21A,GRID2,RIMS1,GPC6,ZNF385B,RELN
6.801e-11	-23.41	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	31	16828	48	PCDH9,PTPRG,NPAS3,EPHA5,CACNA2D1,SLC1A3,CADPS2,CDH18,GRID2,LSAMP,SYT1,UNC5C,DTNA,NRXN3,RELN,CNTN4,GPC6,RIMS1,FSTL5,EBF1,TLL1,GRIA4,RIMS2,NRG3,MYT1L,TRPM3,SLC35F3,CNTNAP2,NRG1,RALYL,CNTN5
6.801e-11	-23.41	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	31	16828	48	RALYL,NRG1,CNTNAP2,SLC35F3,CNTN5,EBF1,FSTL5,GRIA4,TLL1,RIMS2,TRPM3,MYT1L,NRG3,GRID2,CADPS2,CDH18,NRXN3,DTNA,UNC5C,SYT1,LSAMP,CNTN4,RELN,RIMS1,GPC6,PTPRG,PCDH9,EPHA5,NPAS3,SLC1A3,CACNA2D1
1.478e-10	-22.63	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	33	16828	48	EPHA5,SLC1A3,CACNA2D1,CHN2,PCDH9,PTPRG,RELN,RIMS1,GPC6,ZNF385B,KIF21A,CADPS2,CDH18,GRID2,SYT1,LSAMP,UNC5C,DTNA,NRXN3,RIMS2,NRG3,EBF1,FSTL5,TLL1,GRIA4,STXBP5L,ANK2,ZNF385D,KCNJ3,SLC35F3,CNTNAP2,NRG1,RALYL
1.526e-10	-22.60	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	19	16828	48	FSTL5,EBF1,PTPRG,NFIA,EPHA5,NPAS3,NRG3,CADPS2,GRID2,UNC5C,CNTNAP2,LSAMP,RALYL,RUNX1T1,RELN,STXBP5L,RIMS1,GPC6,ZNF385B
1.526e-10	-22.60	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	19	16828	48	NRG3,NPAS3,EPHA5,PTPRG,NFIA,FSTL5,EBF1,RIMS1,GPC6,ZNF385B,RELN,STXBP5L,LSAMP,UNC5C,CNTNAP2,RUNX1T1,RALYL,CADPS2,GRID2
4.303e-10	-21.57	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	23	16828	48	CNTNAP2,RUNX1T1,NRXN3,CDH18,GRID2,GPC6,RIMS1,GRIK2,ZNF385B,RELN,CNTN5,LRRTM4,CNTN4,STXBP5L,PCDH9,ST18,GRIA4,EBF1,FSTL5,NPAS3,RIMS2,EPHA5,NRXN1
4.393e-10	-21.55	larynx	COSMIC cancer mutations	larynx	1948	23	16828	48	RIMS1,GPC6,ZNF385B,RELN,CNTN4,NRXN3,CDH18,GRID2,NPAS3,EPHA5,NRXN1,PCDH9,ST18,GRIK2,CNTN5,LRRTM4,STXBP5L,CNTNAP2,RUNX1T1,RIMS2,GRIA4,EBF1,FSTL5
1.057e-09	-20.67	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	45	16828	48	GRID2,CADPS2,CDH18,KIF21A,SYT1,RELN,ZNF385B,APOE,RIMS1,NFIA,PCDH9,NRXN1,NPAS3,SLC1A3,RALYL,RUNX1T1,NRG1,SLC35F3,STXBP5L,LRRTM4,KCNJ3,ZNF385D,RIMS2,TRPM3,NRG3,NRXN3,DTNA,UNC5C,LSAMP,CNTN4,GPC6,PTPRG,GLCE,EPHA5,CACNA2D1,LINGO2,CNTNAP2,CNTN5,GRIK2,ANK2,FSTL5,EBF1,GRIA4,TLL1,MYT1L
1.643e-09	-20.23	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	39	16828	48	ST18,PTPRG,GLCE,PCDH9,CHN2,CACNA2D1,NRXN1,NPAS3,EPHA5,NRXN3,UNC5C,GRID2,KIF21A,CADPS2,CDH18,GPC6,RIMS1,CNTN4,RELN,TLL1,GRIA4,FSTL5,EBF1,TRPM3,MYT1L,NRG3,RIMS2,NRG1,RUNX1T1,RALYL,SLC35F3,CNTNAP2,LINGO2,KCNJ3,ANK2,GRIK2,ZNF385D,STXBP5L,CNTN5
1.780e-09	-20.15	modulation of chemical synaptic transmission	biological process	GO:0050804	494	12	18204	45	APOE,GRIA4,SLC1A3,GRIK2,RELN,SYT1,CNTN4,NRG3,GRID2,NRXN1,RIMS1,RIMS2
1.821e-09	-20.12	regulation of trans-synaptic signaling	biological process	GO:0099177	495	12	18204	45	APOE,GRIA4,SLC1A3,RELN,GRIK2,GRID2,SYT1,CNTN4,NRG3,NRXN1,RIMS2,RIMS1
2.146e-09	-19.96	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	37	16828	48	TRPM3,NRG3,MYT1L,RIMS2,GRIA4,TLL1,FSTL5,EBF1,GRIK2,ANK2,ZNF385D,STXBP5L,LRRTM4,RALYL,NRG1,SLC35F3,CNTNAP2,CACNA2D1,SLC1A3,EPHA5,NPAS3,PTPRG,ST18,NFIA,PCDH9,ZNF385B,APOE,RIMS1,GPC6,RELN,NRXN3,UNC5C,LSAMP,GRID2,CDH18,CADPS2,KIF21A
2.610e-09	-19.76	humerus	COSMIC cancer mutations	humerus	546	13	16828	48	NRXN3,CNTNAP2,GRID2,CDH18,ZNF385B,KCNJ3,RIMS1,GPC6,GRIA4,ST18,FSTL5,CHN2,EPHA5
3.831e-09	-19.38	anterograde trans-synaptic signaling	biological process	GO:0098916	415	11	18204	45	NRXN1,RIMS2,RIMS1,DTNA,GRID2,SYT1,SLC1A3,CADPS2,GRIK2,APOE,GRIA4
3.831e-09	-19.38	chemical synaptic transmission	biological process	GO:0007268	415	11	18204	45	SLC1A3,NRXN1,GRIK2,RIMS1,RIMS2,CADPS2,DTNA,GRIA4,APOE,SYT1,GRID2
4.122e-09	-19.31	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	32	16828	48	CNTN4,RELN,ZNF385B,RIMS1,GRID2,CADPS2,CDH18,KIF21A,NRXN3,DTNA,EPHA5,CHN2,SLC1A3,CACNA2D1,ST18,PTPRG,PCDH9,STXBP5L,CNTN5,KCNJ3,ANK2,NRG1,SLC35F3,CNTNAP2,RIMS2,TRPM3,NRG3,MYT1L,EBF1,FSTL5,GRIA4,TLL1
4.122e-09	-19.31	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	32	16828	48	TLL1,GRIA4,EBF1,FSTL5,TRPM3,MYT1L,NRG3,RIMS2,NRG1,SLC35F3,CNTNAP2,KCNJ3,ANK2,STXBP5L,CNTN5,PTPRG,ST18,PCDH9,CHN2,CACNA2D1,SLC1A3,EPHA5,DTNA,NRXN3,GRID2,KIF21A,CADPS2,CDH18,ZNF385B,RIMS1,CNTN4,RELN
4.964e-09	-19.12	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	17	16828	48	FSTL5,PTPRG,ST18,TLL1,EPHA5,NRG3,CACNA2D1,GRID2,CDH18,NRXN3,UNC5C,CNTNAP2,SLC35F3,CNTN5,ZNF385D,ANK2,GPC6
5.391e-09	-19.04	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	29	16828	48	STXBP5L,ANK2,ZNF385D,KCNJ3,SLC35F3,CNTNAP2,RALYL,NRG1,NRG3,EBF1,FSTL5,GRIA4,TLL1,RELN,GPC6,RIMS1,ZNF385B,CADPS2,KIF21A,GRID2,UNC5C,LSAMP,SYT1,NRXN3,EPHA5,CACNA2D1,CHN2,PCDH9,PTPRG
5.676e-09	-18.99	trans-synaptic signaling	biological process	GO:0099537	431	11	18204	45	SLC1A3,CADPS2,GRIK2,GRIA4,APOE,NRXN1,RIMS2,RIMS1,DTNA,GRID2,SYT1
5.934e-09	-18.94	cell-cell signaling	biological process	GO:0007267	822	14	18204	45	GRIA4,APOE,SLC1A3,GRIK2,CADPS2,KCNJ3,DTNA,SYT1,CACNA2D1,ANK2,GRID2,NRXN1,RIMS1,RIMS2
8.451e-09	-18.59	presynaptic membrane	cellular component	GO:0042734	168	8	19108	48	NRXN1,KCNJ3,GRIK2,SYT1,NRXN3,RIMS2,RIMS1,CNTN5
1.089e-08	-18.34	synaptic signaling	biological process	GO:0099536	459	11	18204	45	SLC1A3,NRXN1,GRIK2,RIMS1,CADPS2,RIMS2,APOE,DTNA,GRIA4,SYT1,GRID2
2.920e-08	-17.35	Neuronal System	REACTOME pathways	R-HSA-112316	349	10	10285	30	LRRTM4,GRIA4,NRXN3,CACNA2D1,NRXN1,RIMS1,KCNJ3,GRIK2,SLC1A3,SYT1
3.085e-08	-17.29	adenoma	COSMIC cancer mutations	adenoma	2873	25	16828	48	PCDH9,EPHA5,NPAS3,CACNA2D1,CDH18,GRID2,UNC5C,SYT1,NRXN3,RELN,CNTN4,ZNF385B,APOE,FSTL5,EBF1,GRIA4,RIMS2,MYT1L,TRPM3,LINGO2,CNTNAP2,RUNX1T1,NRG1,CNTN5,GRIK2
3.756e-08	-17.10	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	46	16828	48	CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,MYT1L,EBF1,FSTL5,GRIA4,TLL1,CNTN4,GPC6,NRXN3,DTNA,UNC5C,LSAMP,EPHA5,CACNA2D1,PTPRG,GLCE,STXBP5L,LRRTM4,KCNJ3,ZNF385D,RALYL,NRG1,RUNX1T1,SLC35F3,RIMS2,TRPM3,NRG3,RELN,ZNF385B,APOE,RIMS1,GRID2,CDH18,CADPS2,KIF21A,NRXN1,NPAS3,CHN2,SLC1A3,ST18,NFIA,PCDH9
3.756e-08	-17.10	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	46	16828	48	NRG1,RUNX1T1,RALYL,SLC35F3,KCNJ3,ZNF385D,STXBP5L,LRRTM4,TRPM3,NRG3,RIMS2,GRID2,KIF21A,CADPS2,CDH18,APOE,ZNF385B,RIMS1,RELN,NFIA,ST18,PCDH9,CHN2,SLC1A3,NRXN1,NPAS3,CNTNAP2,LINGO2,ANK2,GRIK2,CNTN5,TLL1,GRIA4,EBF1,FSTL5,MYT1L,DTNA,NRXN3,LSAMP,UNC5C,GPC6,CNTN4,PTPRG,GLCE,CACNA2D1,EPHA5
4.010e-08	-17.03	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	COSMIC cancer mutations	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	181	8	16828	48	GRID2,CDH18,SLC35F3,CNTNAP2,NPAS3,RELN,CNTN5,EPHA5
4.186e-08	-16.99	WNT_subtype	COSMIC cancer mutations	WNT_subtype	182	8	16828	48	CDH18,GRID2,SLC35F3,CNTNAP2,NPAS3,RELN,CNTN5,EPHA5
5.405e-08	-16.73	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	39	16828	48	KCNJ3,ZNF385D,ANK2,STXBP5L,CNTN5,NRG1,RALYL,SLC35F3,CNTNAP2,LINGO2,TRPM3,NRG3,RIMS2,TLL1,GRIA4,EBF1,FSTL5,ZNF385B,RIMS1,GPC6,CNTN4,RELN,NRXN3,LSAMP,SYT1,UNC5C,GRID2,KIF21A,CADPS2,CHN2,CACNA2D1,SLC1A3,NRXN1,NPAS3,EPHA5,PTPRG,NFIA,ST18,PCDH9
5.918e-08	-16.64	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	39	16828	48	NRG3,MYT1L,TRPM3,RIMS2,GRIA4,TLL1,EBF1,GRIK2,ANK2,ZNF385D,KCNJ3,CST3,CNTN5,STXBP5L,CNTNAP2,RALYL,RUNX1T1,NRG1,CACNA2D1,CHN2,EPHA5,NPAS3,NRXN1,GLCE,PCDH9,PTPRG,NFIA,ST18,RIMS1,GPC6,ZNF385B,RELN,CNTN4,UNC5C,LSAMP,SYT1,NRXN3,CDH18,KIF21A
5.918e-08	-16.64	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	39	16828	48	RALYL,NRG1,RUNX1T1,CNTNAP2,KCNJ3,GRIK2,ZNF385D,ANK2,STXBP5L,CNTN5,CST3,GRIA4,TLL1,EBF1,TRPM3,MYT1L,NRG3,RIMS2,NRXN3,UNC5C,SYT1,LSAMP,CDH18,KIF21A,ZNF385B,GPC6,RIMS1,CNTN4,RELN,ST18,PTPRG,NFIA,PCDH9,GLCE,CHN2,CACNA2D1,NRXN1,EPHA5,NPAS3
7.510e-08	-16.40	neuron projection	cellular component	GO:0043005	1331	16	19108	48	DTNA,GRIK2,SYT1,CNTN4,GRIA4,UNC5C,GRID2,PCDH9,KIF21A,RELN,APOE,CNTN5,CNTNAP2,ANK2,EPHA5,SLC1A3
8.550e-08	-16.27	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	39	16828	48	MYT1L,NRG3,GRIA4,TLL1,EBF1,FSTL5,ANK2,GRIK2,ZNF385D,KCNJ3,CNTN5,LRRTM4,STXBP5L,CNTNAP2,SLC35F3,RALYL,RUNX1T1,NRG1,LINGO2,CACNA2D1,SLC1A3,CHN2,EPHA5,PCDH9,GLCE,ST18,PTPRG,RIMS1,GPC6,ZNF385B,RELN,UNC5C,SYT1,LSAMP,NRXN3,CADPS2,CDH18,KIF21A,GRID2
8.619e-08	-16.27	mouth	COSMIC cancer mutations	mouth	9004	43	16828	48	RUNX1T1,RALYL,SLC35F3,KCNJ3,ZNF385D,STXBP5L,CST3,LRRTM4,TRPM3,NRG3,RIMS2,SYT1,GRID2,KIF21A,CDH18,APOE,ZNF385B,RIMS1,RELN,ST18,PCDH9,SLC1A3,NRXN1,NPAS3,CNTNAP2,LINGO2,GRIK2,ANK2,CNTN5,TLL1,GRIA4,FSTL5,MYT1L,DTNA,NRXN3,LSAMP,UNC5C,GPC6,CNTN4,PTPRG,GLCE,CACNA2D1,EPHA5
9.202e-08	-16.20	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	27	16828	48	RELN,RIMS1,GPC6,ZNF385B,CADPS2,CDH18,KIF21A,GRID2,UNC5C,NRXN3,EPHA5,PCDH9,ST18,CNTN5,LRRTM4,ZNF385D,ANK2,KCNJ3,LINGO2,CNTNAP2,RUNX1T1,RIMS2,NRG3,TRPM3,FSTL5,GRIA4,TLL1
9.316e-08	-16.19	middle_third	COSMIC cancer mutations	middle_third	3533	27	16828	48	EPHA5,ST18,PCDH9,ZNF385B,RIMS1,GPC6,RELN,NRXN3,UNC5C,GRID2,CADPS2,CDH18,KIF21A,TRPM3,NRG3,RIMS2,GRIA4,TLL1,FSTL5,KCNJ3,ZNF385D,ANK2,LRRTM4,CNTN5,RUNX1T1,CNTNAP2,LINGO2
9.955e-08	-16.12	femur	COSMIC cancer mutations	femur	1197	16	16828	48	CNTNAP2,UNC5C,SYT1,NRXN3,CDH18,KIF21A,GRID2,ZNF385B,STXBP5L,CNTN4,PCDH9,PTPRG,ST18,GRIA4,TLL1,NRG3
1.070e-07	-16.05	positive regulation of synaptic transmission	biological process	GO:0050806	157	7	18204	45	SYT1,RIMS1,GRIK2,RIMS2,RELN,NRXN1,SLC1A3
1.291e-07	-15.86	modulation of excitatory postsynaptic potential	biological process	GO:0098815	49	5	18204	45	NRXN1,RELN,RIMS2,GRIK2,RIMS1
1.305e-07	-15.85	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	36	16828	48	NRXN1,EPHA5,NPAS3,CACNA2D1,PTPRG,PCDH9,CNTN4,RELN,RIMS1,GPC6,GRID2,CADPS2,CDH18,KIF21A,NRXN3,UNC5C,RIMS2,TRPM3,NRG3,MYT1L,FSTL5,EBF1,GRIA4,TLL1,STXBP5L,CNTN5,LRRTM4,KCNJ3,GRIK2,ANK2,LINGO2,RALYL,RUNX1T1,NRG1,SLC35F3,CNTNAP2
1.477e-07	-15.73	regulation of membrane potential	biological process	GO:0042391	463	10	18204	45	CACNA2D1,ANK2,GRID2,GRIA4,KCNJ3,RIMS2,RELN,GRIK2,RIMS1,NRXN1
1.762e-07	-15.55	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	34	16828	48	GRIK2,ANK2,KCNJ3,CNTN5,CST3,STXBP5L,SLC35F3,CNTNAP2,RUNX1T1,LINGO2,MYT1L,NRG3,TRPM3,RIMS2,GRIA4,TLL1,FSTL5,GPC6,RIMS1,RELN,UNC5C,LSAMP,NRXN3,DTNA,CDH18,CADPS2,KIF21A,GRID2,CACNA2D1,SLC1A3,EPHA5,NPAS3,ST18,PTPRG
1.762e-07	-15.55	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	34	16828	48	EPHA5,NPAS3,CACNA2D1,SLC1A3,PTPRG,ST18,RELN,RIMS1,GPC6,CADPS2,CDH18,KIF21A,GRID2,UNC5C,LSAMP,NRXN3,DTNA,RIMS2,NRG3,MYT1L,TRPM3,FSTL5,GRIA4,TLL1,CNTN5,CST3,STXBP5L,GRIK2,ANK2,KCNJ3,LINGO2,CNTNAP2,SLC35F3,RUNX1T1
2.255e-07	-15.30	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	26	16828	48	NRXN1,EPHA5,PTPRG,ST18,PCDH9,CNTN4,RELN,ZNF385B,GRID2,CDH18,KIF21A,SYT1,RIMS2,TRPM3,NRG3,EBF1,FSTL5,TLL1,STXBP5L,CNTN5,ANK2,ZNF385D,GRIK2,RUNX1T1,CNTNAP2,SLC35F3
3.273e-07	-14.93	plasma membrane	cellular component	GO:0005886	5538	31	19108	48	LRRTM4,GRIK2,CDH18,DTNA,CST3,GRIA4,STXBP5L,CNTN4,RIMS2,NRXN1,PCDH9,LSAMP,GRID2,CNTN5,RELN,SLC1A3,CACNA2D1,EPHA5,ANK2,CNTNAP2,SYT1,KCNJ3,TRPM3,GPC6,NRG3,UNC5C,NRG1,APOE,PTPRG,NRXN3,RIMS1
4.332e-07	-14.65	cell projection	cellular component	GO:0042995	2398	20	19108	48	NRXN1,PCDH9,GRID2,KIF21A,RELN,CNTN5,APOE,CNTNAP2,RIMS1,SLC1A3,NRXN3,ANK2,EPHA5,GRIK2,SYT1,DTNA,CNTN4,GRIA4,RIMS2,UNC5C
5.308e-07	-14.45	cell junction organization	biological process	GO:0034330	532	10	18204	45	NRG3,CNTN4,CNTN5,GRID2,ANK2,APOE,RELN,NRXN1,NFIA,CDH18
5.805e-07	-14.36	cell periphery	cellular component	GO:0071944	6020	32	19108	48	SLC1A3,EPHA5,CACNA2D1,ANK2,CNTNAP2,CNTN5,RELN,PCDH9,NRXN1,LSAMP,GRID2,RIMS2,STXBP5L,GRIA4,CNTN4,CST3,LRRTM4,GRIK2,DTNA,CDH18,PTPRG,NRXN3,RIMS1,APOE,NRG1,UNC5C,LINGO2,GPC6,NRG3,TRPM3,SYT1,KCNJ3
5.806e-07	-14.36	bone	COSMIC cancer mutations	bone	8157	40	16828	48	ST18,PTPRG,GLCE,PCDH9,CHN2,CACNA2D1,SLC1A3,NRXN1,NPAS3,EPHA5,DTNA,NRXN3,LSAMP,SYT1,UNC5C,GRID2,KIF21A,CDH18,ZNF385B,GPC6,RIMS1,CNTN4,RELN,TLL1,GRIA4,FSTL5,TRPM3,NRG3,MYT1L,NRG1,RUNX1T1,CNTNAP2,LINGO2,KCNJ3,ANK2,GRIK2,STXBP5L,LRRTM4,CNTN5,CST3
6.422e-07	-14.26	cell morphogenesis	biological process	GO:0000902	687	11	18204	45	CNTN4,NFIA,NRXN1,NRXN3,EPHA5,CNTN5,CDH18,SLC1A3,CNTNAP2,UNC5C,RELN
8.103e-07	-14.03	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	7	16828	48	NRG3,GRID2,PCDH9,SYT1,CNTNAP2,PTPRG,GRIA4
8.676e-07	-13.96	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	12	16828	48	KIF21A,CDH18,GRID2,CNTNAP2,DTNA,RELN,RIMS1,ANK2,EBF1,RIMS2,EPHA5,SLC1A3
1.020e-06	-13.80	regulation of synaptic plasticity	biological process	GO:0048167	219	7	18204	45	RIMS2,RELN,RIMS1,GRIK2,APOE,GRID2,CNTN4
1.114e-06	-13.71	positive regulation of excitatory postsynaptic potential	biological process	GO:2000463	32	4	18204	45	NRXN1,RELN,RIMS2,RIMS1
1.183e-06	-13.65	neurotransmitter transport	biological process	GO:0006836	140	6	18204	45	SYT1,RIMS1,RIMS2,CADPS2,NRXN1,SLC1A3
1.186e-06	-13.64	axon guidance	biological process	GO:0007411	224	7	18204	45	EPHA5,NRXN3,RELN,UNC5C,NRXN1,CNTN5,CNTN4
1.186e-06	-13.64	neuron projection guidance	biological process	GO:0097485	224	7	18204	45	NRXN1,UNC5C,RELN,EPHA5,NRXN3,CNTN4,CNTN5
1.243e-06	-13.60	I-set	pfam domains	PF07679	132	6	17795	47	UNC5C,CNTN4,LINGO2,LSAMP,NRG1,CNTN5
1.255e-06	-13.59	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	28	16828	48	EPHA5,PCDH9,NFIA,RELN,RIMS1,GPC6,KIF21A,CDH18,CADPS2,UNC5C,NRXN3,RIMS2,NRG3,MYT1L,TRPM3,EBF1,FSTL5,TLL1,GRIA4,LRRTM4,CNTN5,STXBP5L,GRIK2,ANK2,KCNJ3,LINGO2,CNTNAP2,RUNX1T1
1.271e-06	-13.58	Ig_I-set	interpro domains	IPR013098	132	6	18521	49	LSAMP,NRG1,UNC5C,LINGO2,CNTN5,CNTN4
1.305e-06	-13.55	neuron differentiation	biological process	GO:0030182	1081	13	18204	45	UNC5C,CNTNAP2,SLC1A3,RELN,APOE,CNTN5,NRXN1,NFIA,EPHA5,NRXN3,CNTN4,MYT1L,GRID2
1.330e-06	-13.53	lower_third	COSMIC cancer mutations	lower_third	7961	39	16828	48	RIMS1,GPC6,ZNF385B,RELN,CNTN4,UNC5C,NRXN3,CADPS2,CDH18,KIF21A,GRID2,CACNA2D1,CHN2,EPHA5,NPAS3,NRXN1,PCDH9,PTPRG,ST18,ANK2,GRIK2,KCNJ3,CNTN5,LRRTM4,STXBP5L,CNTNAP2,SLC35F3,RALYL,RUNX1T1,NRG1,LINGO2,MYT1L,NRG3,TRPM3,RIMS2,GRIA4,TLL1,EBF1,FSTL5
1.342e-06	-13.52	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	45	16828	48	RIMS2,NRG3,TRPM3,LRRTM4,CST3,STXBP5L,ZNF385D,KCNJ3,SLC35F3,RALYL,NRG1,RUNX1T1,NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,ST18,RELN,RIMS1,ZNF385B,CADPS2,CDH18,KIF21A,GRID2,SYT1,MYT1L,EBF1,FSTL5,GRIA4,TLL1,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,EPHA5,CACNA2D1,GLCE,PTPRG,CNTN4,UNC5C,LSAMP,NRXN3,DTNA
1.378e-06	-13.49	synapse organization	biological process	GO:0050808	333	8	18204	45	RELN,NRXN1,NFIA,CNTN5,NRG3,CNTN4,GRID2,APOE
1.562e-06	-13.37	pleura-pulmonary_blastoma	COSMIC cancer mutations	pleura-pulmonary_blastoma	648	11	16828	48	PTPRG,ST18,EPHA5,RIMS2,KIF21A,LINGO2,CDH18,CADPS2,CNTNAP2,RUNX1T1,RIMS1
1.562e-06	-13.37	pulmonary_blastoma	COSMIC cancer mutations	pulmonary_blastoma	648	11	16828	48	RIMS1,CNTNAP2,RUNX1T1,KIF21A,LINGO2,CADPS2,CDH18,EPHA5,RIMS2,PTPRG,ST18
1.675e-06	-13.30	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	25	16828	48	RIMS2,MYT1L,TRPM3,FSTL5,LRRTM4,GRIK2,LINGO2,CNTNAP2,NRG1,RUNX1T1,EPHA5,NPAS3,CHN2,PCDH9,ST18,PTPRG,RELN,RIMS1,ZNF385B,CADPS2,CDH18,KIF21A,GRID2,UNC5C,NRXN3
1.725e-06	-13.27	nervous system development	biological process	GO:0007399	2185	18	18204	45	RELN,SLC1A3,LSAMP,CNTNAP2,UNC5C,CNTN5,APOE,NRG1,PCDH9,EPHA5,NRXN3,NRXN1,NFIA,ANK2,GRID2,MYT1L,NRG3,CNTN4
1.755e-06	-13.25	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	18	16828	48	NRXN3,SYT1,CNTNAP2,UNC5C,GRID2,CDH18,ZNF385B,RIMS1,ANK2,RELN,CNTN5,TLL1,PTPRG,ST18,PCDH9,MYT1L,CACNA2D1,EPHA5
1.768e-06	-13.25	extremity	COSMIC cancer mutations	extremity	1876	18	16828	48	ST18,PTPRG,TLL1,PCDH9,EPHA5,MYT1L,CACNA2D1,GRID2,CDH18,NRXN3,UNC5C,CNTNAP2,SYT1,CNTN5,RELN,ZNF385B,ANK2,RIMS1
1.816e-06	-13.22	Protein-protein interactions at synapses	REACTOME pathways	R-HSA-6794362	72	5	10285	30	NRXN3,LRRTM4,GRIA4,SYT1,NRXN1
1.868e-06	-13.19	plasma membrane region	cellular component	GO:0098590	1278	14	19108	48	LRRTM4,GRIK2,SYT1,KCNJ3,RIMS2,GRIA4,NRXN1,GRID2,SLC1A3,NRXN3,ANK2,CNTNAP2,RIMS1,CNTN5
2.276e-06	-12.99	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	7	10285	30	KCNJ3,CACNA2D1,GRIA4,GRIK2,SLC1A3,SYT1,RIMS1
2.427e-06	-12.93	EGF-like_dom	interpro domains	IPR000742	232	7	18521	49	NRG1,NRXN3,TLL1,RELN,NRXN1,CNTNAP2,NRG3
2.469e-06	-12.91	neurotransmitter secretion	biological process	GO:0007269	88	5	18204	45	NRXN1,SYT1,RIMS1,CADPS2,RIMS2
2.469e-06	-12.91	signal release from synapse	biological process	GO:0099643	88	5	18204	45	RIMS1,SYT1,RIMS2,CADPS2,NRXN1
2.603e-06	-12.86	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	11	16828	48	NRXN1,EPHA5,NRG3,CACNA2D1,EBF1,GRIA4,PTPRG,STXBP5L,GPC6,GRIK2,CNTNAP2
2.603e-06	-12.86	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	11	16828	48	EPHA5,NRXN1,NRG3,CACNA2D1,EBF1,PTPRG,GRIA4,STXBP5L,GPC6,GRIK2,CNTNAP2
2.811e-06	-12.78	generation of neurons	biological process	GO:0048699	1158	13	18204	45	RELN,SLC1A3,CNTNAP2,UNC5C,CNTN5,APOE,NRXN3,EPHA5,NRXN1,NFIA,GRID2,MYT1L,CNTN4
2.955e-06	-12.73	Ig_sub2	interpro domains	IPR003598	239	7	18521	49	LSAMP,NRG1,UNC5C,LINGO2,CNTN5,FSTL5,CNTN4
2.975e-06	-12.73	EGF_3	prosite domains	PS50026	196	7	12186	40	NRXN1,NRG1,CNTNAP2,NRG3,NRXN3,TLL1,RELN
3.057e-06	-12.70	auditory behavior	biological process	GO:0031223	12	3	18204	45	CNTNAP2,NRXN1,SLC1A3
3.468e-06	-12.57	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	15	16828	48	TRPM3,CACNA2D1,MYT1L,EPHA5,TLL1,PTPRG,PCDH9,KCNJ3,ANK2,GRIK2,STXBP5L,CNTN5,NRXN3,CNTNAP2,KIF21A
3.725e-06	-12.50	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	45	16828	48	SLC1A3,CHN2,NPAS3,NRXN1,PCDH9,ST18,RIMS1,ZNF385B,RELN,SYT1,KIF21A,CDH18,CADPS2,GRID2,NRG3,TRPM3,RIMS2,ZNF385D,KCNJ3,LRRTM4,CST3,STXBP5L,SLC35F3,NRG1,RUNX1T1,RALYL,CACNA2D1,EPHA5,GLCE,PTPRG,CNTN4,LSAMP,UNC5C,DTNA,NRXN3,MYT1L,TLL1,GRIA4,FSTL5,EBF1,GRIK2,ANK2,CNTN5,CNTNAP2,LINGO2
3.934e-06	-12.45	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	15	16828	48	CNTNAP2,NRXN3,KIF21A,ANK2,GRIK2,KCNJ3,CNTN5,STXBP5L,PCDH9,PTPRG,TLL1,MYT1L,CACNA2D1,TRPM3,EPHA5
3.936e-06	-12.45	axon	cellular component	GO:0030424	650	10	19108	48	UNC5C,EPHA5,CNTNAP2,CNTN5,CNTN4,KIF21A,PCDH9,DTNA,SYT1,GRIK2
4.755e-06	-12.26	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	18	16828	48	NRG3,FSTL5,EBF1,PCDH9,TLL1,ST18,RELN,CNTN4,GPC6,ZNF385D,GRIK2,ANK2,CDH18,GRID2,SYT1,UNC5C,CNTNAP2,NRG1
4.755e-06	-12.26	mucosal	COSMIC cancer mutations	mucosal	2009	18	16828	48	SYT1,CNTNAP2,UNC5C,NRG1,CDH18,GRID2,GPC6,GRIK2,ZNF385D,ANK2,RELN,CNTN4,PCDH9,TLL1,ST18,EBF1,FSTL5,NRG3
4.928e-06	-12.22	receptor clustering	biological process	GO:0043113	46	4	18204	45	RELN,GRIK2,APOE,NRXN1
4.968e-06	-12.21	pharynx	COSMIC cancer mutations	pharynx	2696	21	16828	48	RELN,GPC6,RIMS1,ANK2,ZNF385B,LINGO2,CDH18,UNC5C,CNTNAP2,DTNA,NRXN3,NPAS3,MYT1L,NRG3,EBF1,GLCE,PCDH9,TLL1,PTPRG,ST18,NFIA
5.041e-06	-12.20	mechanosensory behavior	biological process	GO:0007638	14	3	18204	45	SLC1A3,NRXN1,CNTNAP2
5.627e-06	-12.09	neuron development	biological process	GO:0048666	859	11	18204	45	APOE,MYT1L,CNTN4,CNTN5,SLC1A3,NRXN1,CNTNAP2,UNC5C,RELN,EPHA5,NRXN3
5.766e-06	-12.06	somatodendritic compartment	cellular component	GO:0036477	842	11	19108	48	RELN,APOE,GRIA4,CNTNAP2,EPHA5,UNC5C,SLC1A3,GRIK2,GRID2,NRXN1,KIF21A
5.855e-06	-12.05	calcium-ion regulated exocytosis	biological process	GO:0017156	48	4	18204	45	RIMS2,CADPS2,RIMS1,SYT1
6.102e-06	-12.01	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	7	16828	48	NRG3,NPAS3,CNTNAP2,SYT1,PCDH9,NFIA,CADPS2
6.102e-06	-12.01	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	7	16828	48	CADPS2,CNTNAP2,PCDH9,SYT1,NFIA,NPAS3,NRG3
6.206e-06	-11.99	Neurexin-like	interpro domains	IPR003585	14	3	18521	49	CNTNAP2,NRXN3,NRXN1
7.729e-06	-11.77	neuron cell-cell adhesion	biological process	GO:0007158	16	3	18204	45	CNTN4,NRXN3,NRXN1
8.691e-06	-11.65	trunk	COSMIC cancer mutations	trunk	3554	24	16828	48	ST18,PTPRG,PCDH9,NRXN1,NPAS3,CACNA2D1,SLC1A3,GRID2,KIF21A,NRXN3,LSAMP,CNTN4,RELN,EBF1,GRIA4,TLL1,RIMS2,MYT1L,NRG3,SLC35F3,STXBP5L,CNTN5,ANK2,GRIK2
8.918e-06	-11.63	regulation of system process	biological process	GO:0044057	571	9	18204	45	ANK2,CACNA2D1,APOE,KCNJ3,RELN,RIMS2,RIMS1,GRIK2,NRXN1
8.945e-06	-11.62	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	35	16828	48	ANK2,ZNF385D,GRIK2,KCNJ3,LRRTM4,CNTN5,CST3,STXBP5L,SLC35F3,CNTNAP2,RUNX1T1,LINGO2,NRG3,MYT1L,TRPM3,RIMS2,GRIA4,FSTL5,RIMS1,GPC6,ZNF385B,RELN,CNTN4,LSAMP,DTNA,NRXN3,CDH18,GRID2,CACNA2D1,EPHA5,NRXN1,PCDH9,GLCE,ST18,PTPRG
9.832e-06	-11.53	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	26	16828	48	EBF1,GRIA4,RIMS2,TRPM3,MYT1L,LINGO2,RUNX1T1,RALYL,STXBP5L,LRRTM4,ANK2,ZNF385D,GRIK2,ST18,NFIA,PCDH9,GLCE,NRXN1,GRID2,DTNA,NRXN3,LSAMP,SYT1,RELN,GPC6,RIMS1
1.028e-05	-11.49	presynapse	cellular component	GO:0098793	569	9	19108	48	NRXN1,CADPS2,SYT1,GRIK2,KCNJ3,RIMS1,RIMS2,NRXN3,CNTN5
1.069e-05	-11.45	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	14	16828	48	TRPM3,NPAS3,TLL1,GRIA4,ZNF385B,ZNF385D,GRIK2,ANK2,RUNX1T1,NRXN3,SYT1,GRID2,LINGO2,CDH18
1.122e-05	-11.40	calcium ion-regulated exocytosis of neurotransmitter	biological process	GO:0048791	18	3	18204	45	RIMS2,SYT1,RIMS1
1.129e-05	-11.39	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	8	18204	45	CNTN4,CNTN5,EPHA5,NRXN3,RELN,UNC5C,NRXN1,SLC1A3
1.133e-05	-11.39	regulation of nervous system process	biological process	GO:0031644	120	5	18204	45	NRXN1,RIMS1,GRIK2,RELN,RIMS2
1.245e-05	-11.29	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	20	16828	48	PCDH9,GLCE,TLL1,ST18,PTPRG,NRG3,CACNA2D1,SLC1A3,TRPM3,NRXN1,CNTNAP2,RUNX1T1,NRXN3,LINGO2,CDH18,GRID2,GPC6,GRIK2,RELN,CNTN4
1.304e-05	-11.25	arm	COSMIC cancer mutations	arm	1331	14	16828	48	SYT1,NRXN3,RUNX1T1,CDH18,LINGO2,GRID2,GRIK2,ANK2,ZNF385D,ZNF385B,GRIA4,TLL1,TRPM3,NPAS3
1.318e-05	-11.24	neurogenesis	biological process	GO:0022008	1334	13	18204	45	GRID2,CNTN4,MYT1L,EPHA5,NRXN3,NFIA,NRXN1,CNTN5,APOE,RELN,SLC1A3,UNC5C,CNTNAP2
1.330e-05	-11.23	vocalization behavior	biological process	GO:0071625	19	3	18204	45	NRXN1,CNTNAP2,NRXN3
1.370e-05	-11.20	Lig_chan	pfam domains	PF00060	18	3	17795	47	GRID2,GRIA4,GRIK2
1.370e-05	-11.20	Lig_chan-Glu_bd	pfam domains	PF10613	18	3	17795	47	GRIK2,GRIA4,GRID2
1.381e-05	-11.19	Ionotropic_Glu_rcpt	interpro domains	IPR015683	18	3	18521	49	GRIK2,GRIA4,GRID2
1.381e-05	-11.19	Glu/Gly-bd	interpro domains	IPR019594	18	3	18521	49	GRIK2,GRID2,GRIA4
1.381e-05	-11.19	Iono_Glu_rcpt_met	interpro domains	IPR001508	18	3	18521	49	GRID2,GRIA4,GRIK2
1.381e-05	-11.19	Iontro_rcpt_C	interpro domains	IPR001320	18	3	18521	49	GRIK2,GRIA4,GRID2
1.414e-05	-11.17	LRRTM3 (leucine rich repeat transmembrane neuronal 3)	protein interactions	347731	19	3	19454	49	NRXN3,LRRTM4,GPC6
1.525e-05	-11.09	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	20	16828	48	ST18,GRIA4,PTPRG,PCDH9,NRXN1,RIMS2,SLC1A3,MYT1L,NRG3,CACNA2D1,GRID2,NRXN3,LSAMP,SLC35F3,CNTN4,STXBP5L,RELN,CNTN5,ANK2,GRIK2
1.558e-05	-11.07	Ig-like_fold	interpro domains	IPR013783	721	10	18521	49	CNTN4,PTPRG,UNC5C,NRG1,LSAMP,CNTN5,FSTL5,LINGO2,EPHA5,EBF1
1.745e-05	-10.96	synaptic vesicle exocytosis	biological process	GO:0016079	63	4	18204	45	SYT1,RIMS1,CADPS2,RIMS2
1.811e-05	-10.92	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	43	16828	48	SLC35F3,CNTNAP2,RALYL,NRG1,RUNX1T1,LINGO2,ANK2,GRIK2,ZNF385D,LRRTM4,CNTN5,STXBP5L,GRIA4,TLL1,EBF1,FSTL5,MYT1L,NRG3,TRPM3,RIMS2,UNC5C,LSAMP,SYT1,NRXN3,CDH18,CADPS2,KIF21A,GRID2,RIMS1,GPC6,ZNF385B,RELN,CNTN4,PCDH9,NFIA,ST18,PTPRG,CACNA2D1,SLC1A3,CHN2,EPHA5,NPAS3,NRXN1
1.811e-05	-10.92	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	43	16828	48	NRXN1,NPAS3,EPHA5,CHN2,CACNA2D1,SLC1A3,ST18,PTPRG,NFIA,PCDH9,CNTN4,RELN,ZNF385B,RIMS1,GPC6,GRID2,KIF21A,CDH18,CADPS2,NRXN3,SYT1,LSAMP,UNC5C,RIMS2,TRPM3,MYT1L,NRG3,FSTL5,EBF1,TLL1,GRIA4,STXBP5L,CNTN5,LRRTM4,ANK2,ZNF385D,GRIK2,LINGO2,NRG1,RUNX1T1,RALYL,CNTNAP2,SLC35F3
1.950e-05	-10.85	4.1m	smart domains	SM00294	14	3	9717	38	NRXN1,CNTNAP2,NRXN3
2.034e-05	-10.80	dendrite	cellular component	GO:0030425	620	9	19108	48	GRID2,CNTNAP2,EPHA5,UNC5C,KIF21A,RELN,GRIK2,APOE,GRIA4
2.045e-05	-10.80	MYT1	pfam domains	PF08474	3	2	17795	47	MYT1L,ST18
2.054e-05	-10.79	Myelin_TF	interpro domains	IPR013681	3	2	18521	49	ST18,MYT1L
2.054e-05	-10.79	Neuregulin	interpro domains	IPR040180	3	2	18521	49	NRG3,NRG1
2.087e-05	-10.78	dendritic tree	cellular component	GO:0097447	622	9	19108	48	GRID2,KIF21A,GRIK2,CNTNAP2,UNC5C,EPHA5,RELN,GRIA4,APOE
2.203e-05	-10.72	neuron projection morphogenesis	biological process	GO:0048812	486	8	18204	45	CNTN5,CNTN4,RELN,NRXN3,EPHA5,NRXN1,UNC5C,CNTNAP2
2.237e-05	-10.71	Interactions of neurexins and neuroligins at synapses	REACTOME pathways	R-HSA-6794361	58	4	10285	30	NRXN1,SYT1,LRRTM4,NRXN3
2.256e-05	-10.70	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	15	16828	48	NRXN1,EPHA5,RIMS2,ST18,STXBP5L,CNTN4,RELN,KCNJ3,GRIK2,ANK2,NRXN3,NRG1,UNC5C,SYT1,LSAMP
2.370e-05	-10.65	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	8	18204	45	CNTN4,CNTN5,CNTNAP2,UNC5C,NRXN1,EPHA5,NRXN3,RELN
2.501e-05	-10.60	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	17	16828	48	KIF21A,CDH18,LSAMP,CNTNAP2,RELN,CNTN4,STXBP5L,GPC6,ZNF385D,ANK2,ZNF385B,PCDH9,ST18,EPHA5,NRG3,CACNA2D1,TRPM3
2.549e-05	-10.58	cell projection morphogenesis	biological process	GO:0048858	496	8	18204	45	CNTN5,CNTN4,NRXN3,EPHA5,RELN,UNC5C,CNTNAP2,NRXN1
2.641e-05	-10.54	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-follicular_lymphoma	208	6	16828	48	RELN,RIMS2,GRID2,PCDH9,CNTNAP2,KCNJ3
2.666e-05	-10.53	neuronal cell body	cellular component	GO:0043025	489	8	19108	48	NRXN1,GRIK2,CNTNAP2,UNC5C,EPHA5,SLC1A3,APOE,GRIA4
2.673e-05	-10.53	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	15	16828	48	TLL1,FSTL5,RIMS2,RUNX1T1,DTNA,NRXN3,GRID2,CDH18,RIMS1,GRIK2,ZNF385D,ANK2,CNTN4,RELN,CNTN5
2.673e-05	-10.53	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	15	16828	48	RIMS2,TLL1,FSTL5,GRIK2,ANK2,ZNF385D,RIMS1,CNTN4,CNTN5,RELN,NRXN3,DTNA,RUNX1T1,GRID2,CDH18
2.755e-05	-10.50	positive regulation of dendrite extension	biological process	GO:1903861	24	3	18204	45	RIMS2,SYT1,RIMS1
2.947e-05	-10.43	axonogenesis	biological process	GO:0007409	366	7	18204	45	NRXN1,UNC5C,RELN,EPHA5,NRXN3,CNTN4,CNTN5
3.211e-05	-10.35	NMDARECEPTOR	prints domains	PR00177	18	3	5227	19	GRID2,GRIK2,GRIA4
3.227e-05	-10.34	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	44	16828	48	EPHA5,CACNA2D1,PTPRG,CNTN4,GPC6,DTNA,NRXN3,LSAMP,UNC5C,MYT1L,EBF1,FSTL5,TLL1,GRIA4,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,NRXN1,NPAS3,CHN2,SLC1A3,NFIA,ST18,PCDH9,RELN,ZNF385B,RIMS1,GRID2,KIF21A,CADPS2,CDH18,SYT1,RIMS2,TRPM3,NRG3,STXBP5L,LRRTM4,ZNF385D,RUNX1T1,NRG1,RALYL,SLC35F3
3.283e-05	-10.32	IGc2	smart domains	SM00408	239	7	9717	38	FSTL5,CNTN5,LINGO2,CNTN4,UNC5C,LSAMP,NRG1
3.574e-05	-10.24	NMDA glutamate receptor clustering	biological process	GO:0097114	4	2	18204	45	RELN,APOE
3.591e-05	-10.23	glutamate receptor activity	molecular function	GO:0008066	26	3	18094	45	GRIA4,GRID2,GRIK2
3.617e-05	-10.23	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	2	18094	45	RELN,APOE
3.632e-05	-10.22	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	13	16828	48	FSTL5,ST18,PTPRG,RIMS2,NRG3,LINGO2,CDH18,CNTNAP2,RELN,CNTN5,GPC6,GRIK2,ANK2
3.632e-05	-10.22	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	13	16828	48	NRG3,RIMS2,ST18,PTPRG,FSTL5,ANK2,GRIK2,GPC6,CNTN5,RELN,CNTNAP2,CDH18,LINGO2
3.865e-05	-10.16	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	4	18204	45	NRXN1,SYT1,GRIK2,RELN
3.935e-05	-10.14	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	46	16828	48	PTPRG,GLCE,CACNA2D1,EPHA5,DTNA,NRXN3,LSAMP,UNC5C,GPC6,CNTN4,TLL1,GRIA4,FSTL5,EBF1,MYT1L,CNTNAP2,LINGO2,GRIK2,ANK2,CNTN5,NFIA,ST18,PCDH9,CHN2,SLC1A3,NRXN1,NPAS3,SYT1,GRID2,KIF21A,CDH18,CADPS2,ZNF385B,RIMS1,RELN,TRPM3,NRG3,RIMS2,RUNX1T1,NRG1,RALYL,SLC35F3,KCNJ3,ZNF385D,STXBP5L,LRRTM4
3.961e-05	-10.14	regulation of dendrite extension	biological process	GO:1903859	27	3	18204	45	RIMS1,SYT1,RIMS2
3.961e-05	-10.14	cell-cell signaling involved in cardiac conduction	biological process	GO:0086019	27	3	18204	45	KCNJ3,ANK2,CACNA2D1
3.969e-05	-10.13	gallbladder	COSMIC cancer mutations	gallbladder	2821	20	16828	48	CDH18,GRID2,CNTNAP2,UNC5C,NRG1,RELN,CNTN5,CNTN4,RIMS1,ANK2,GRIK2,ZNF385B,EBF1,PCDH9,TLL1,PTPRG,ST18,NRG3,CACNA2D1,TRPM3
3.969e-05	-10.13	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	20	16828	48	EBF1,PCDH9,ST18,PTPRG,TLL1,CACNA2D1,NRG3,TRPM3,CDH18,GRID2,UNC5C,CNTNAP2,NRG1,CNTN5,RELN,CNTN4,GRIK2,ANK2,RIMS1,ZNF385B
3.986e-05	-10.13	scalp	COSMIC cancer mutations	scalp	2110	17	16828	48	GRID2,LSAMP,SYT1,UNC5C,NRG1,NRXN3,RELN,CNTN4,STXBP5L,GRIK2,ANK2,KCNJ3,NFIA,ST18,RIMS2,EPHA5,NRXN1
4.100e-05	-10.10	Rim-like	interpro domains	IPR039032	4	2	18521	49	RIMS2,RIMS1
4.129e-05	-10.09	neuron projection development	biological process	GO:0031175	693	9	18204	45	CNTN4,CNTN5,APOE,RELN,EPHA5,NRXN3,NRXN1,UNC5C,CNTNAP2
4.286e-05	-10.06	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	36	16828	48	FSTL5,EBF1,GRIA4,TLL1,TRPM3,NRG3,LINGO2,RALYL,NRG1,RUNX1T1,CNTNAP2,SLC35F3,STXBP5L,LRRTM4,KCNJ3,ZNF385D,ANK2,PTPRG,ST18,PCDH9,EPHA5,CHN2,CACNA2D1,SLC1A3,GRID2,CADPS2,KIF21A,NRXN3,UNC5C,LSAMP,SYT1,RELN,ZNF385B,APOE,GPC6,RIMS1
4.324e-05	-10.05	Lig_chan-Glu_bd	smart domains	SM00918	18	3	9717	38	GRID2,GRIK2,GRIA4
4.324e-05	-10.05	PBPe	smart domains	SM00079	18	3	9717	38	GRIA4,GRID2,GRIK2
4.349e-05	-10.04	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	3	10285	30	SYT1,RIMS1,SLC1A3
4.453e-05	-10.02	Periplasmic binding protein-like II	gene3d domains	3.40.190.10	23	3	14470	44	GRIK2,GRIA4,GRID2
4.636e-05	-9.98	anatomical structure morphogenesis	biological process	GO:0009653	2225	16	18204	45	ANK2,GRID2,NRG3,CNTN4,NRXN1,NFIA,NRXN3,EPHA5,APOE,NRG1,CNTN5,CDH18,SLC1A3,CNTNAP2,UNC5C,RELN
4.702e-05	-9.96	Immunoglobulins	gene3d domains	2.60.40.10	721	10	14470	44	NRG1,PTPRG,CNTN4,FSTL5,EPHA5,LINGO2,LSAMP,UNC5C,CNTN5,EBF1
4.755e-05	-9.95	face	COSMIC cancer mutations	face	2139	17	16828	48	KIF21A,CDH18,LSAMP,CNTNAP2,STXBP5L,CNTN4,RELN,ZNF385B,GPC6,ZNF385D,ANK2,ST18,PCDH9,EPHA5,TRPM3,CACNA2D1,NRG3
4.931e-05	-9.92	regulation of presynaptic membrane potential	biological process	GO:0099505	29	3	18204	45	GRIK2,KCNJ3,GRIA4
4.931e-05	-9.92	postsynaptic membrane organization	biological process	GO:0001941	29	3	18204	45	NRXN1,APOE,RELN
5.020e-05	-9.90	lipoprotein particle receptor binding	molecular function	GO:0070325	29	3	18094	45	SYT1,APOE,RELN
5.799e-05	-9.76	brain development	biological process	GO:0007420	724	9	18204	45	PCDH9,CNTN5,NRG3,CNTN4,GRID2,CNTNAP2,UNC5C,EPHA5,RELN
5.839e-05	-9.75	Laminin	gene3d domains	2.10.25.10	226	6	14470	44	NRG1,TLL1,NRG3,CNTNAP2,NRXN3,NRXN1
6.019e-05	-9.72	neuroligin family protein binding	molecular function	GO:0097109	5	2	18094	45	NRXN1,NRXN3
6.609e-05	-9.62	cell body	cellular component	GO:0044297	556	8	19108	48	CNTNAP2,SLC1A3,EPHA5,UNC5C,GRIA4,APOE,NRXN1,GRIK2
6.794e-05	-9.60	cell communication	biological process	GO:0007154	5010	25	18204	45	RIMS2,EPHA5,NRXN1,GRID2,SYT1,DTNA,KCNJ3,RELN,SLC1A3,CNTNAP2,NRG1,GRIA4,APOE,RIMS1,ZNF385B,NFIA,CHN2,CACNA2D1,ANK2,NRG3,CADPS2,GRIK2,PTPRG,UNC5C,ST18
6.812e-05	-9.59	cell junction assembly	biological process	GO:0034329	285	6	18204	45	ANK2,GRID2,CNTN5,NRG3,CDH18,NRXN1
6.822e-05	-9.59	Znf_C2H2C_sf	interpro domains	IPR036060	5	2	18521	49	ST18,MYT1L
7.045e-05	-9.56	axon development	biological process	GO:0061564	420	7	18204	45	EPHA5,NRXN3,RELN,UNC5C,NRXN1,CNTN4,CNTN5
7.070e-05	-9.56	glutamatergic synapse	cellular component	GO:0098978	412	7	19108	48	CADPS2,GRID2,APOE,GRIK2,SYT1,GPC6,NRG3
7.087e-05	-9.55	EGF	smart domains	SM00181	184	6	9717	38	NRXN1,RELN,NRG1,NRXN3,CNTNAP2,TLL1
7.312e-05	-9.52	response to auditory stimulus	biological process	GO:0010996	33	3	18204	45	NRXN1,SLC1A3,CNTNAP2
7.433e-05	-9.51	Ig_sub	interpro domains	IPR003599	394	7	18521	49	CNTN4,NRG1,LSAMP,UNC5C,CNTN5,FSTL5,LINGO2
7.769e-05	-9.46	VLDLR (very low density lipoprotein receptor)	protein interactions	7436	33	3	19454	49	APOE,SYT1,RELN
7.998e-05	-9.43	cell adhesion	biological process	GO:0007155	942	10	18204	45	GRID2,CNTN5,CNTN4,PCDH9,RELN,NRXN3,CDH18,LSAMP,NRXN1,CNTNAP2
8.698e-05	-9.35	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	16	19108	48	DTNA,GRIK2,SYT1,GRIA4,CNTN4,UNC5C,KIF21A,GRID2,PCDH9,APOE,CNTN5,RELN,ANK2,EPHA5,SLC1A3,CNTNAP2
8.821e-05	-9.34	chondrosarcoma	COSMIC cancer mutations	chondrosarcoma	1181	12	16828	48	CHN2,ST18,RIMS1,ZNF385B,LRRTM4,STXBP5L,CNTN4,LSAMP,UNC5C,CNTNAP2,CDH18,GRID2
8.907e-05	-9.33	positive regulation of inhibitory postsynaptic potential	biological process	GO:0097151	6	2	18204	45	RIMS1,RIMS2
8.907e-05	-9.33	vocal learning	biological process	GO:0042297	6	2	18204	45	CNTNAP2,NRXN1
8.907e-05	-9.33	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	2	18204	45	RELN,NRXN1
8.907e-05	-9.33	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	2	18204	45	NRG1,NRG3
8.907e-05	-9.33	imitative learning	biological process	GO:0098596	6	2	18204	45	NRXN1,CNTNAP2
9.194e-05	-9.29	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	34	16828	48	RELN,RIMS1,GPC6,ZNF385B,APOE,CADPS2,KIF21A,GRID2,UNC5C,LSAMP,SYT1,NRXN3,EPHA5,SLC1A3,CACNA2D1,CHN2,PCDH9,PTPRG,ST18,LRRTM4,STXBP5L,ZNF385D,ANK2,KCNJ3,CNTNAP2,SLC35F3,RALYL,RUNX1T1,NRG1,NRG3,EBF1,FSTL5,GRIA4,TLL1
9.363e-05	-9.28	functioning	COSMIC cancer mutations	functioning	1803	15	16828	48	KCNJ3,RIMS1,GRIK2,ANK2,STXBP5L,RUNX1T1,NRXN3,UNC5C,CADPS2,CDH18,TRPM3,NRG3,MYT1L,PTPRG,PCDH9
9.363e-05	-9.28	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	15	16828	48	NRG3,MYT1L,TRPM3,PCDH9,PTPRG,STXBP5L,ANK2,GRIK2,RIMS1,KCNJ3,CDH18,CADPS2,UNC5C,NRXN3,RUNX1T1
9.688e-05	-9.24	head development	biological process	GO:0060322	774	9	18204	45	RELN,EPHA5,UNC5C,CNTNAP2,GRID2,CNTN5,NRG3,CNTN4,PCDH9
9.734e-05	-9.24	signal release	biological process	GO:0023061	188	5	18204	45	NRXN1,CADPS2,RIMS2,SYT1,RIMS1
1.017e-04	-9.19	Syndecan	pfam domains	PF01034	6	2	17795	47	NRXN1,NRXN3
1.017e-04	-9.19	zf-C2HC	pfam domains	PF01530	6	2	17795	47	ST18,MYT1L
1.022e-04	-9.19	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	2	18521	49	NRXN3,NRXN1
1.037e-04	-9.17	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	6	16828	48	FSTL5,CNTN5,RUNX1T1,APOE,GRIA4,CNTNAP2
1.078e-04	-9.14	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	4	19454	49	SYT1,LSAMP,ANK2,CACNA2D1
1.138e-04	-9.08	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	47	16828	48	PCDH9,ST18,NFIA,NPAS3,NRXN1,SLC1A3,CHN2,CDH18,CADPS2,KIF21A,GRID2,SYT1,RELN,RIMS1,ZNF385B,APOE,RIMS2,NRG3,TRPM3,SLC35F3,RALYL,RUNX1T1,CST3,LRRTM4,STXBP5L,ZNF385D,KCNJ3,GLCE,PTPRG,EPHA5,CACNA2D1,UNC5C,LSAMP,NRXN3,DTNA,CNTN4,GPC6,FSTL5,EBF1,GRIA4,TLL1,MYT1L,LINGO2,CNTNAP2,CNTN5,GRIK2,ANK2
1.160e-04	-9.06	Laminin_G_2	pfam domains	PF02210	36	3	17795	47	NRXN3,NRXN1,CNTNAP2
1.245e-04	-8.99	observational learning	biological process	GO:0098597	7	2	18204	45	NRXN1,CNTNAP2
1.245e-04	-8.99	modulation of inhibitory postsynaptic potential	biological process	GO:0098828	7	2	18204	45	RIMS2,RIMS1
1.245e-04	-8.99	spontaneous neurotransmitter secretion	biological process	GO:0061669	7	2	18204	45	SYT1,RIMS2
1.260e-04	-8.98	ANF_receptor	pfam domains	PF01094	37	3	17795	47	GRIK2,GRID2,GRIA4
1.269e-04	-8.97	ANF_lig-bd_rcpt	interpro domains	IPR001828	37	3	18521	49	GRID2,GRIA4,GRIK2
1.308e-04	-8.94	regulation of heart rate by cardiac conduction	biological process	GO:0086091	40	3	18204	45	ANK2,CACNA2D1,KCNJ3
1.319e-04	-8.93	Ig-like_dom	interpro domains	IPR007110	432	7	18521	49	UNC5C,LSAMP,NRG1,CNTN4,LINGO2,FSTL5,CNTN5
1.345e-04	-8.91	-	gene3d domains	4.10.320.30	6	2	14470	44	MYT1L,ST18
1.420e-04	-8.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	13	16828	48	GRIA4,EPHA5,NRXN1,MYT1L,CHN2,TRPM3,KIF21A,CNTNAP2,LSAMP,RELN,STXBP5L,GRIK2,RIMS1
1.428e-04	-8.85	Znf_C2H2C	interpro domains	IPR002515	7	2	18521	49	MYT1L,ST18
1.438e-04	-8.85	membrane	cellular component	GO:0016020	9220	36	19108	48	CST3,DTNA,CDH18,GRIK2,LRRTM4,RIMS2,CHN2,CNTN4,STXBP5L,GRIA4,GRID2,PCDH9,NRXN1,LSAMP,CNTNAP2,CACNA2D1,EPHA5,ANK2,SLC1A3,RELN,CNTN5,TRPM3,KCNJ3,SYT1,NRG1,LINGO2,UNC5C,GPC6,NRG3,CADPS2,GLCE,SLC35F3,RIMS1,NRXN3,PTPRG,APOE
1.483e-04	-8.82	ionotropic glutamate receptor complex	cellular component	GO:0008328	41	3	19108	48	GRIK2,GRIA4,GRID2
1.487e-04	-8.81	Peripla_BP_I	interpro domains	IPR028082	39	3	18521	49	GRIA4,GRID2,GRIK2
1.520e-04	-8.79	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	31	16828	48	TRPM3,NRG3,MYT1L,FSTL5,TLL1,GRIA4,STXBP5L,LRRTM4,CNTN5,KCNJ3,ANK2,LINGO2,NRG1,CNTNAP2,NRXN1,EPHA5,CHN2,CACNA2D1,NFIA,PTPRG,ST18,GLCE,RELN,ZNF385B,GPC6,RIMS1,GRID2,KIF21A,CADPS2,CDH18,NRXN3
1.520e-04	-8.79	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	31	16828	48	CADPS2,CDH18,KIF21A,GRID2,NRXN3,RELN,GPC6,RIMS1,ZNF385B,GLCE,ST18,PTPRG,NFIA,EPHA5,NRXN1,CACNA2D1,CHN2,LINGO2,CNTNAP2,NRG1,CNTN5,LRRTM4,STXBP5L,ANK2,KCNJ3,FSTL5,GRIA4,TLL1,MYT1L,NRG3,TRPM3
1.554e-04	-8.77	positive regulation of cell junction assembly	biological process	GO:1901890	110	4	18204	45	CNTNAP2,NRXN1,LINGO2,GRID2
1.582e-04	-8.75	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	5	19454	49	NRXN1,NRXN3,CNTNAP2,DTNA,GRIK2
1.626e-04	-8.72	regulation of synaptic vesicle exocytosis	biological process	GO:2000300	43	3	18204	45	RIMS2,SYT1,RIMS1
1.657e-04	-8.71	ERBB4 signaling pathway	biological process	GO:0038130	8	2	18204	45	NRG1,NRG3
1.683e-04	-8.69	metal ion binding	molecular function	GO:0046872	4239	22	18094	45	NRXN1,CACNA2D1,RUNX1T1,APOE,FSTL5,DTNA,RIMS2,PCDH9,RELN,SLC1A3,ZNF385D,ZNF385B,EBF1,RIMS1,CHN2,MYT1L,GLCE,TLL1,NRXN3,CADPS2,ST18,SYT1
1.714e-04	-8.67	cytoskeleton of presynaptic active zone	cellular component	GO:0048788	8	2	19108	48	RIMS2,RIMS1
1.728e-04	-8.66	Laminin_G	interpro domains	IPR001791	41	3	18521	49	CNTNAP2,NRXN3,NRXN1
1.742e-04	-8.66	synaptic transmission, glutamatergic	biological process	GO:0035249	44	3	18204	45	GRIA4,GRID2,GRIK2
1.758e-04	-8.65	cell differentiation	biological process	GO:0030154	3645	20	18204	45	CNTNAP2,TLL1,UNC5C,SLC1A3,RELN,APOE,NRG1,CNTN5,NRXN1,NFIA,RIMS1,NRXN3,EPHA5,RIMS2,FSTL5,MYT1L,SYT1,CNTN4,GRID2,ANK2
1.760e-04	-8.65	multicellular organism development	biological process	GO:0007275	3957	21	18204	45	CNTN5,PCDH9,APOE,NRG1,RELN,CNTNAP2,UNC5C,TLL1,CDH18,SLC1A3,LSAMP,FSTL5,MYT1L,CNTN4,NRG3,ANK2,GRID2,NRXN3,EPHA5,NFIA,NRXN1
1.779e-04	-8.63	cellular developmental process	biological process	GO:0048869	3648	20	18204	45	CNTN5,NRG1,APOE,RELN,UNC5C,TLL1,CNTNAP2,SLC1A3,CNTN4,SYT1,FSTL5,MYT1L,GRID2,ANK2,RIMS1,EPHA5,NRXN3,RIMS2,NFIA,NRXN1
1.831e-04	-8.61	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	3	5310	12	SLC1A3,SYT1,RIMS1
1.863e-04	-8.59	cardiac muscle cell action potential involved in contraction	biological process	GO:0086002	45	3	18204	45	CACNA2D1,ANK2,KCNJ3
1.863e-04	-8.59	cell communication involved in cardiac conduction	biological process	GO:0086065	45	3	18204	45	CACNA2D1,ANK2,KCNJ3
1.863e-04	-8.59	glutamate receptor signaling pathway	biological process	GO:0007215	45	3	18204	45	GRID2,GRIK2,GRIA4
1.907e-04	-8.56	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	13	16828	48	ST18,TLL1,PCDH9,GLCE,NPAS3,NRG3,LINGO2,NRXN3,DTNA,CNTNAP2,ZNF385B,ANK2,GPC6
1.924e-04	-8.56	signaling	biological process	GO:0023052	4968	24	18204	45	ST18,GRIK2,CADPS2,UNC5C,PTPRG,NRG3,ANK2,CACNA2D1,RIMS1,NFIA,CHN2,ZNF385B,APOE,NRG1,GRIA4,RELN,SLC1A3,SYT1,GRID2,KCNJ3,DTNA,EPHA5,RIMS2,NRXN1
1.989e-04	-8.52	negative chemotaxis	biological process	GO:0050919	46	3	18204	45	NRG3,NRG1,UNC5C
1.994e-04	-8.52	LAM_G_DOMAIN	prosite domains	PS50025	35	3	12186	40	NRXN3,NRXN1,CNTNAP2
2.036e-04	-8.50	synapse assembly	biological process	GO:0007416	118	4	18204	45	GRID2,CNTN5,NRG3,NRXN1
2.053e-04	-8.49	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	12	16828	48	PTPRG,MYT1L,EPHA5,RIMS2,NRXN3,CNTNAP2,KIF21A,RIMS1,ZNF385D,CNTN4,RELN,CNTN5
2.093e-04	-8.47	neurotransmitter receptor complex	cellular component	GO:0098878	46	3	19108	48	GRID2,GRIA4,GRIK2
2.114e-04	-8.46	monoatomic ion channel complex	cellular component	GO:0034702	344	6	19108	48	GRIA4,KCNJ3,GRIK2,CACNA2D1,GRID2,CNTNAP2
2.121e-04	-8.46	regulation of neuron migration	biological process	GO:2001222	47	3	18204	45	RELN,NRG3,UNC5C
2.127e-04	-8.46	positive regulation of synapse maturation	biological process	GO:0090129	9	2	18204	45	RELN,NRXN1
2.127e-04	-8.46	spontaneous synaptic transmission	biological process	GO:0098814	9	2	18204	45	RIMS2,SYT1
2.171e-04	-8.43	striated muscle contraction	biological process	GO:0006941	120	4	18204	45	KCNJ3,DTNA,ANK2,CACNA2D1
2.183e-04	-8.43	ZF_CCHHC	prosite domains	PS51802	7	2	12186	40	ST18,MYT1L
2.252e-04	-8.40	GRIA1 (glutamate ionotropic receptor AMPA type subunit 1)	protein interactions	2890	47	3	19454	49	GRIK2,GRID2,GRIA4
2.378e-04	-8.34	system process	biological process	GO:0003008	2015	14	18204	45	APOE,CNTN5,SLC1A3,CNTNAP2,RELN,GRIK2,DTNA,KCNJ3,CACNA2D1,ANK2,GRID2,NRXN1,RIMS1,NRXN3
2.430e-04	-8.32	cation binding	molecular function	GO:0043169	4341	22	18094	45	GLCE,MYT1L,SYT1,ST18,CADPS2,TLL1,NRXN3,SLC1A3,ZNF385B,ZNF385D,RELN,CHN2,RIMS1,EBF1,RIMS2,FSTL5,APOE,DTNA,PCDH9,NRXN1,CACNA2D1,RUNX1T1
2.462e-04	-8.31	action potential	biological process	GO:0001508	124	4	18204	45	KCNJ3,GRIK2,ANK2,CACNA2D1
2.596e-04	-8.26	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	40	16828	48	EBF1,FSTL5,GRIA4,TLL1,RIMS2,MYT1L,NRG3,TRPM3,LINGO2,CNTNAP2,SLC35F3,NRG1,RUNX1T1,LRRTM4,CST3,CNTN5,STXBP5L,ANK2,GRIK2,KCNJ3,PCDH9,PTPRG,NFIA,ST18,EPHA5,NPAS3,NRXN1,CACNA2D1,CHN2,CDH18,CADPS2,KIF21A,GRID2,SYT1,NRXN3,DTNA,RELN,CNTN4,RIMS1,ZNF385B
2.614e-04	-8.25	Ig-like_dom_sf	interpro domains	IPR036179	483	7	18521	49	CNTN4,CNTN5,FSTL5,LINGO2,UNC5C,NRG1,LSAMP
2.635e-04	-8.24	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	40	16828	48	GRID2,CADPS2,CDH18,KIF21A,NRXN3,DTNA,SYT1,CNTN4,RELN,ZNF385B,RIMS1,ST18,PTPRG,NFIA,PCDH9,NRXN1,EPHA5,NPAS3,CHN2,CACNA2D1,LINGO2,RUNX1T1,NRG1,SLC35F3,CNTNAP2,STXBP5L,CST3,LRRTM4,CNTN5,KCNJ3,ANK2,GRIK2,FSTL5,EBF1,GRIA4,TLL1,RIMS2,TRPM3,NRG3,MYT1L
2.655e-04	-8.23	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	2	18204	45	NRXN1,CNTNAP2
2.705e-04	-8.22	cardiac muscle cell contraction	biological process	GO:0086003	51	3	18204	45	ANK2,CACNA2D1,KCNJ3
2.906e-04	-8.14	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	10	16828	48	EPHA5,RIMS2,ANK2,CACNA2D1,MYT1L,TRPM3,CADPS2,NRXN3,GRIA4,RUNX1T1
2.906e-04	-8.14	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	10	16828	48	CADPS2,RUNX1T1,NRXN3,GRIA4,EPHA5,RIMS2,TRPM3,MYT1L,CACNA2D1,ANK2
3.015e-04	-8.11	T-tubule	cellular component	GO:0030315	52	3	19108	48	CACNA2D1,ANK2,KCNJ3
3.033e-04	-8.10	biological process involved in intraspecies interaction between organisms	biological process	GO:0051703	53	3	18204	45	NRXN3,NRXN1,CNTNAP2
3.033e-04	-8.10	social behavior	biological process	GO:0035176	53	3	18204	45	NRXN3,NRXN1,CNTNAP2
3.087e-04	-8.08	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	molecular function	GO:1904315	53	3	18094	45	GRIA4,GRID2,GRIK2
3.095e-04	-8.08	exocytosis	biological process	GO:0006887	241	5	18204	45	RIMS2,STXBP5L,CADPS2,RIMS1,SYT1
3.219e-04	-8.04	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	48	CACNA2D1,EPHA5,PTPRG,GLCE,GPC6,CNTN4,DTNA,NRXN3,LSAMP,UNC5C,MYT1L,TLL1,GRIA4,EBF1,FSTL5,ANK2,GRIK2,CNTN5,CNTNAP2,LINGO2,CHN2,SLC1A3,NRXN1,NPAS3,ST18,NFIA,PCDH9,APOE,ZNF385B,RIMS1,RELN,SYT1,GRID2,KIF21A,CADPS2,CDH18,TRPM3,NRG3,RIMS2,KCNJ3,ZNF385D,STXBP5L,LRRTM4,CST3,RUNX1T1,NRG1,RALYL,SLC35F3
3.342e-04	-8.00	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	16	16828	48	MYT1L,NRG3,TRPM3,PCDH9,PTPRG,GRIK2,ANK2,RIMS1,ZNF385B,KCNJ3,STXBP5L,UNC5C,NRXN3,RUNX1T1,CADPS2,CDH18
3.350e-04	-8.00	presynaptic cytoskeleton	cellular component	GO:0099569	11	2	19108	48	RIMS2,RIMS1
3.352e-04	-8.00	caecum	COSMIC cancer mutations	caecum	14248	48	16828	48	RIMS2,TRPM3,NRG3,RUNX1T1,NRG1,RALYL,SLC35F3,STXBP5L,CST3,LRRTM4,KCNJ3,ZNF385D,ST18,NFIA,PCDH9,NRXN1,NPAS3,CHN2,SLC1A3,GRID2,KIF21A,CDH18,CADPS2,SYT1,RELN,APOE,ZNF385B,RIMS1,FSTL5,EBF1,TLL1,GRIA4,MYT1L,LINGO2,CNTNAP2,CNTN5,GRIK2,ANK2,PTPRG,GLCE,EPHA5,CACNA2D1,DTNA,NRXN3,LSAMP,UNC5C,CNTN4,GPC6
3.369e-04	-8.00	RIMS3 (regulating synaptic membrane exocytosis 3)	protein interactions	9783	11	2	19454	49	RIMS1,RIMS2
3.401e-04	-7.99	regulation of synapse organization	biological process	GO:0050807	246	5	18204	45	LINGO2,RELN,GRID2,NRXN1,APOE
3.445e-04	-7.97	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	molecular function	GO:0099529	55	3	18094	45	GRIK2,GRID2,GRIA4
3.545e-04	-7.94	cell-cell adhesion	biological process	GO:0098609	546	7	18204	45	NRXN3,CNTN5,CNTN4,GRID2,PCDH9,NRXN1,CDH18
3.570e-04	-7.94	cardiac muscle cell action potential	biological process	GO:0086001	56	3	18204	45	KCNJ3,ANK2,CACNA2D1
3.571e-04	-7.94	Glutamatergic synapse	KEGG pathways	hsa04724	114	4	7161	22	GRIK2,KCNJ3,GRIA4,SLC1A3
3.571e-04	-7.94	Glutamatergic synapse	KEGG pathways	ko04724	114	4	7161	22	GRIK2,KCNJ3,SLC1A3,GRIA4
3.582e-04	-7.93	transmembrane transporter binding	molecular function	GO:0044325	136	4	18094	45	ANK2,RIMS1,RIMS2,CNTNAP2
3.648e-04	-7.92	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	2	10285	30	NRG1,NRG3
3.699e-04	-7.90	ZU5	pfam domains	PF00791	11	2	17795	47	ANK2,UNC5C
3.724e-04	-7.90	system development	biological process	GO:0048731	3533	19	18204	45	MYT1L,CNTN4,NRG3,ANK2,GRID2,EPHA5,NRXN3,NFIA,NRXN1,CNTN5,PCDH9,APOE,NRG1,RELN,CNTNAP2,TLL1,UNC5C,LSAMP,SLC1A3
3.798e-04	-7.88	regulation of synapse structure or activity	biological process	GO:0050803	252	5	18204	45	GRID2,RELN,LINGO2,APOE,NRXN1
3.837e-04	-7.87	regulation of cell communication	biological process	GO:0010646	3541	19	18204	45	GRIK2,RELN,SLC1A3,GLCE,GPC6,APOE,NRG1,GRIA4,EPHA5,RIMS1,RIMS2,CHN2,NRXN1,SYT1,FSTL5,CNTN4,NRG3,ANK2,GRID2
3.882e-04	-7.85	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	2	18204	45	RELN,APOE
3.957e-04	-7.83	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	23	16828	48	NFIA,PTPRG,ST18,NPAS3,SLC1A3,GRID2,KIF21A,CADPS2,CDH18,RELN,APOE,RIMS1,EBF1,TLL1,RIMS2,TRPM3,MYT1L,NRG1,CNTNAP2,STXBP5L,LRRTM4,GRIK2,ANK2
4.019e-04	-7.82	Effects of Botulinum toxin	Pathway Interaction DB	botulinumtoxinpathway	9	2	2226	8	SYT1,RIMS1
4.239e-04	-7.77	transmitter-gated monoatomic ion channel activity	molecular function	GO:0022824	59	3	18094	45	GRID2,GRIA4,GRIK2
4.239e-04	-7.77	transmitter-gated channel activity	molecular function	GO:0022835	59	3	18094	45	GRIK2,GRIA4,GRID2
4.244e-04	-7.76	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	3	10285	30	SYT1,RIMS1,SLC1A3
4.349e-04	-7.74	synaptic vesicle cycle	biological process	GO:0099504	144	4	18204	45	CADPS2,RIMS2,SYT1,RIMS1
4.349e-04	-7.74	regulated exocytosis	biological process	GO:0045055	144	4	18204	45	SYT1,RIMS1,CADPS2,RIMS2
4.407e-04	-7.73	IG_LIKE	prosite domains	PS50835	430	7	12186	40	NRG1,CNTN4,UNC5C,LINGO2,CNTN5,LSAMP,FSTL5
4.413e-04	-7.73	sarcolemma	cellular component	GO:0042383	142	4	19108	48	KCNJ3,DTNA,CACNA2D1,ANK2
4.450e-04	-7.72	Rab_BD	interpro domains	IPR010911	12	2	18521	49	RIMS1,RIMS2
4.512e-04	-7.70	fn3	pfam domains	PF00041	136	4	17795	47	EPHA5,CNTN5,PTPRG,CNTN4
4.581e-04	-7.69	prepulse inhibition	biological process	GO:0060134	13	2	18204	45	CNTNAP2,GRID2
4.653e-04	-7.67	-	gene3d domains	3.40.50.2300	50	3	14470	44	GRIK2,GRID2,GRIA4
4.934e-04	-7.61	LamG	smart domains	SM00282	40	3	9717	38	NRXN1,CNTNAP2,NRXN3
4.948e-04	-7.61	neuromuscular process	biological process	GO:0050905	149	4	18204	45	CNTNAP2,SLC1A3,NRXN1,GRID2
5.172e-04	-7.57	Ig_3	pfam domains	PF13927	141	4	17795	47	LSAMP,CNTN5,FSTL5,CNTN4
5.250e-04	-7.55	ZU5_dom	interpro domains	IPR000906	13	2	18521	49	ANK2,UNC5C
5.269e-04	-7.55	ZU5	smart domains	SM00218	9	2	9717	38	ANK2,UNC5C
5.271e-04	-7.55	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	23	16828	48	RELN,RIMS1,APOE,CDH18,CADPS2,KIF21A,GRID2,NPAS3,SLC1A3,ST18,PTPRG,NFIA,LRRTM4,STXBP5L,ANK2,GRIK2,CNTNAP2,NRG1,RIMS2,MYT1L,TRPM3,EBF1,TLL1
5.336e-04	-7.54	atrial cardiac muscle cell to AV node cell signaling	biological process	GO:0086026	14	2	18204	45	KCNJ3,ANK2
5.336e-04	-7.54	atrial cardiac muscle cell action potential	biological process	GO:0086014	14	2	18204	45	ANK2,KCNJ3
5.434e-04	-7.52	regulation of cellular component organization	biological process	GO:0051128	2455	15	18204	45	GLCE,APOE,NRG1,RELN,PTPRG,CNTNAP2,GRID2,CST3,SYT1,NRG3,RIMS2,EPHA5,LINGO2,RIMS1,NRXN1
5.450e-04	-7.51	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	30	16828	48	GRID2,CDH18,KIF21A,UNC5C,SYT1,RELN,ZNF385B,APOE,RIMS1,PTPRG,GLCE,EPHA5,NPAS3,SLC1A3,LINGO2,RALYL,RUNX1T1,CNTNAP2,STXBP5L,LRRTM4,CNTN5,GRIK2,ANK2,ZNF385D,FSTL5,GRIA4,TLL1,TRPM3,MYT1L,NRG3
5.513e-04	-7.50	C2_dom	interpro domains	IPR000008	143	4	18521	49	RIMS1,CADPS2,SYT1,RIMS2
5.535e-04	-7.50	secretion by cell	biological process	GO:0032940	420	6	18204	45	NRXN1,RIMS2,CADPS2,STXBP5L,RIMS1,SYT1
5.539e-04	-7.50	positive regulation of synapse assembly	biological process	GO:0051965	65	3	18204	45	NRXN1,LINGO2,GRID2
5.547e-04	-7.50	SYT5 (synaptotagmin 5)	protein interactions	6861	14	2	19454	49	SYT1,NRXN1
5.603e-04	-7.49	learning	biological process	GO:0007612	154	4	18204	45	CNTNAP2,NRXN1,NRXN3,RELN
5.603e-04	-7.49	vesicle-mediated transport in synapse	biological process	GO:0099003	154	4	18204	45	RIMS1,SYT1,RIMS2,CADPS2
5.749e-04	-7.46	learning or memory	biological process	GO:0007611	276	5	18204	45	APOE,NRXN1,CNTNAP2,RELN,NRXN3
5.817e-04	-7.45	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	9	16828	48	CACNA2D1,ANK2,RELN,RIMS2,STXBP5L,PCDH9,ST18,NFIA,GRID2
5.825e-04	-7.45	excitatory synapse	cellular component	GO:0060076	65	3	19108	48	KCNJ3,SYT1,GRID2
5.887e-04	-7.44	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	22	16828	48	STXBP5L,RELN,CNTN5,LRRTM4,RIMS1,GRIK2,GRID2,KIF21A,LINGO2,CDH18,CADPS2,CNTNAP2,SLC35F3,NPAS3,EPHA5,RIMS2,CHN2,MYT1L,ST18,NFIA,PTPRG,PCDH9
5.909e-04	-7.43	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	22	16828	48	STXBP5L,LRRTM4,CNTN5,GRIK2,LINGO2,SLC35F3,CNTNAP2,RIMS2,MYT1L,RELN,RIMS1,GRID2,KIF21A,CADPS2,CDH18,NPAS3,EPHA5,CHN2,PTPRG,ST18,NFIA,PCDH9
6.084e-04	-7.40	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	17	16828	48	NRXN3,RUNX1T1,UNC5C,CADPS2,CDH18,KCNJ3,ZNF385B,GRIK2,ANK2,RIMS1,STXBP5L,CNTN5,PTPRG,PCDH9,TRPM3,MYT1L,NRG3
6.147e-04	-7.39	atrial cardiac muscle cell to AV node cell communication	biological process	GO:0086066	15	2	18204	45	KCNJ3,ANK2
6.225e-04	-7.38	EGF_2	prosite domains	PS01186	213	5	12186	40	NRG3,RELN,TLL1,EPHA5,NRG1
6.267e-04	-7.38	central nervous system development	biological process	GO:0007417	995	9	18204	45	PCDH9,GRID2,CNTN4,CNTN5,NRG3,UNC5C,CNTNAP2,RELN,EPHA5
6.289e-04	-7.37	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	2	10285	30	NRG3,NRG1
6.544e-04	-7.33	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	4	16828	48	FSTL5,NRG3,CNTNAP2,NRG1
6.545e-04	-7.33	regulation of secretion	biological process	GO:0051046	605	7	18204	45	RIMS2,CADPS2,EPHA5,RIMS1,SYT1,NRG1,APOE
6.669e-04	-7.31	postsynaptic membrane	cellular component	GO:0045211	280	5	19108	48	GRIK2,GRIA4,LRRTM4,GRID2,ANK2
6.693e-04	-7.31	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	22	16828	48	RELN,RIMS1,CADPS2,CDH18,KIF21A,GRID2,EPHA5,NPAS3,CHN2,PCDH9,ST18,PTPRG,NFIA,LRRTM4,CNTN5,STXBP5L,GRIK2,LINGO2,SLC35F3,CNTNAP2,RIMS2,MYT1L
6.791e-04	-7.29	RABBD	prosite domains	PS50916	12	2	12186	40	RIMS1,RIMS2
6.882e-04	-7.28	cardiac conduction	biological process	GO:0061337	70	3	18204	45	CACNA2D1,ANK2,KCNJ3
6.900e-04	-7.28	-	gene3d domains	2.60.220.30	13	2	14470	44	ANK2,UNC5C
6.985e-04	-7.27	embryonal	COSMIC cancer mutations	embryonal	2659	17	16828	48	CNTNAP2,NRG1,CDH18,CADPS2,KIF21A,ANK2,RIMS1,APOE,LRRTM4,RELN,STXBP5L,NFIA,EBF1,MYT1L,TRPM3,RIMS2,NPAS3
6.985e-04	-7.27	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	17	16828	48	RIMS1,ANK2,APOE,RELN,LRRTM4,STXBP5L,CNTNAP2,NRG1,KIF21A,CDH18,CADPS2,MYT1L,TRPM3,NPAS3,RIMS2,NFIA,EBF1
6.993e-04	-7.27	plasma membrane protein complex	cellular component	GO:0098797	600	7	19108	48	GRID2,CNTNAP2,CACNA2D1,KCNJ3,CDH18,GRIK2,GRIA4
7.004e-04	-7.26	postsynaptic neurotransmitter receptor activity	molecular function	GO:0098960	70	3	18094	45	GRIK2,GRIA4,GRID2
7.014e-04	-7.26	positive regulation of CREB transcription factor activity	biological process	GO:0032793	16	2	18204	45	EPHA5,RELN
7.099e-04	-7.25	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0099507	16	2	18094	45	GRIA4,GRIK2
7.099e-04	-7.25	glutamate-gated receptor activity	molecular function	GO:0004970	16	2	18094	45	GRIK2,GRIA4
7.251e-04	-7.23	IG	smart domains	SM00409	394	7	9717	38	FSTL5,CNTN5,UNC5C,NRG1,LSAMP,CNTN4,LINGO2
7.259e-04	-7.23	transmembrane transporter complex	cellular component	GO:1902495	434	6	19108	48	GRIA4,GRIK2,KCNJ3,CACNA2D1,CNTNAP2,GRID2
7.292e-04	-7.22	SYT4 (synaptotagmin 4)	protein interactions	6860	16	2	19454	49	NRXN1,SYT1
7.324e-04	-7.22	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	2	10285	30	NRG1,NRG3
7.377e-04	-7.21	monoatomic ion channel activity	molecular function	GO:0005216	441	6	18094	45	GRID2,CACNA2D1,TRPM3,GRIK2,GRIA4,KCNJ3
7.465e-04	-7.20	upper_leg	COSMIC cancer mutations	upper_leg	880	9	16828	48	CACNA2D1,ANK2,RELN,RIMS2,STXBP5L,PCDH9,ST18,NFIA,GRID2
7.492e-04	-7.20	behavior	biological process	GO:0007610	619	7	18204	45	APOE,RELN,GRIK2,NRXN3,SLC1A3,NRXN1,CNTNAP2
7.504e-04	-7.19	DLG4 (discs large MAGUK scaffold protein 4)	protein interactions	1742	163	4	19454	49	GRIK2,PTPRG,NRG1,CNTNAP2
7.604e-04	-7.18	extracellular ligand-gated monoatomic ion channel activity	molecular function	GO:0005230	72	3	18094	45	GRID2,GRIA4,GRIK2
7.937e-04	-7.14	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	2	18204	45	CACNA2D1,ANK2
8.009e-04	-7.13	ZU5	prosite domains	PS51145	13	2	12186	40	UNC5C,ANK2
8.157e-04	-7.11	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	9	16828	48	RUNX1T1,ST18,PTPRG,NPAS3,RELN,RIMS1,CACNA2D1,MYT1L,ANK2
8.204e-04	-7.11	presynaptic active zone cytoplasmic component	cellular component	GO:0098831	17	2	19108	48	RIMS1,RIMS2
8.295e-04	-7.09	regulation of exocytosis	biological process	GO:0017157	171	4	18204	45	CADPS2,RIMS2,SYT1,RIMS1
8.365e-04	-7.09	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-essential_thrombocythaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-essential_thrombocythaemia	393	6	16828	48	STXBP5L,RELN,LRRTM4,CADPS2,DTNA,GRIA4
8.365e-04	-7.09	essential_thrombocythaemia	COSMIC cancer mutations	essential_thrombocythaemia	393	6	16828	48	DTNA,GRIA4,STXBP5L,RELN,LRRTM4,CADPS2
8.435e-04	-7.08	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	2	10285	30	NRG3,NRG1
8.737e-04	-7.04	multicellular organismal process	biological process	GO:0032501	6177	26	18204	45	PCDH9,CDH18,UNC5C,GRIK2,ANK2,CACNA2D1,NRG3,NFIA,RIMS1,APOE,NRG1,CNTN5,SLC1A3,LSAMP,CNTNAP2,TLL1,RELN,DTNA,KCNJ3,GRID2,FSTL5,MYT1L,CNTN4,NRXN1,NRXN3,EPHA5
8.748e-04	-7.04	actin-mediated cell contraction	biological process	GO:0070252	76	3	18204	45	KCNJ3,CACNA2D1,ANK2
8.972e-04	-7.02	extraskeletal	COSMIC cancer mutations	extraskeletal	903	9	16828	48	CACNA2D1,RIMS1,MYT1L,ANK2,RELN,NPAS3,RUNX1T1,ST18,PTPRG
9.022e-04	-7.01	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	2	18094	45	NRG3,NRG1
9.267e-04	-6.98	GRIK5 (glutamate ionotropic receptor kainate type subunit 5)	protein interactions	2901	18	2	19454	49	GRID2,GRIK2
9.623e-04	-6.95	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	2	10285	30	NRG3,NRG1
9.623e-04	-6.95	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	2	10285	30	NRG1,NRG3
9.929e-04	-6.91	transporter complex	cellular component	GO:1990351	461	6	19108	48	GRID2,CNTNAP2,CACNA2D1,KCNJ3,GRIK2,GRIA4
9.948e-04	-6.91	excitatory synapse assembly	biological process	GO:1904861	19	2	18204	45	GRID2,NRXN1
1.028e-03	-6.88	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	2	19108	48	GRID2,KCNJ3
1.034e-03	-6.87	NLGN1 (neuroligin 1)	protein interactions	22871	19	2	19454	49	NRXN1,NRXN3
1.038e-03	-6.87	-	gene3d domains	1.10.287.70	148	4	14470	44	GRIK2,GRIA4,GRID2,KCNJ3
1.048e-03	-6.86	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	9	16828	48	RUNX1T1,NRXN3,ST18,SYT1,CNTNAP2,GRID2,CACNA2D1,ZNF385D,GRIK2
1.075e-03	-6.84	C2_domain_sf	interpro domains	IPR035892	171	4	18521	49	RIMS2,SYT1,RIMS1,CADPS2
1.080e-03	-6.83	prostate	COSMIC cancer mutations	prostate	13883	47	16828	48	SLC35F3,RALYL,NRG1,RUNX1T1,ZNF385D,KCNJ3,LRRTM4,STXBP5L,NRG3,TRPM3,RIMS2,SYT1,CDH18,CADPS2,KIF21A,GRID2,RIMS1,ZNF385B,APOE,RELN,PCDH9,NFIA,ST18,SLC1A3,CHN2,NPAS3,NRXN1,CNTNAP2,LINGO2,ANK2,GRIK2,CNTN5,GRIA4,TLL1,EBF1,FSTL5,MYT1L,UNC5C,LSAMP,NRXN3,DTNA,GPC6,CNTN4,GLCE,PTPRG,CACNA2D1,EPHA5
1.089e-03	-6.82	Acetylcholine Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-264642	17	2	10285	30	RIMS1,SYT1
1.091e-03	-6.82	regulation of neurotransmitter secretion	biological process	GO:0046928	82	3	18204	45	RIMS2,SYT1,RIMS1
1.102e-03	-6.81	cognition	biological process	GO:0050890	319	5	18204	45	CNTNAP2,NRXN1,APOE,NRXN3,RELN
1.104e-03	-6.81	regulation of synapse maturation	biological process	GO:0090128	20	2	18204	45	RELN,NRXN1
1.114e-03	-6.80	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	8	16828	48	STXBP5L,RIMS2,NRG3,GPC6,CDH18,ST18,CNTNAP2,SLC35F3
1.130e-03	-6.79	cardiac muscle contraction	biological process	GO:0060048	83	3	18204	45	CACNA2D1,ANK2,KCNJ3
1.130e-03	-6.79	positive regulation of ion transmembrane transporter activity	biological process	GO:0032414	83	3	18204	45	ANK2,CACNA2D1,RELN
1.139e-03	-6.78	regulation of signaling	biological process	GO:0023051	3534	18	18204	45	CHN2,NRXN1,RIMS2,RIMS1,EPHA5,GRID2,CNTN4,NRG3,FSTL5,SYT1,SLC1A3,RELN,GRIK2,GRIA4,NRG1,APOE,GPC6,GLCE
1.147e-03	-6.77	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	2	19454	49	CST3,NRXN1
1.147e-03	-6.77	gated channel activity	molecular function	GO:0022836	320	5	18094	45	KCNJ3,CACNA2D1,GRIK2,GRIA4,GRID2
1.159e-03	-6.76	ligand-gated monoatomic ion channel activity	molecular function	GO:0015276	186	4	18094	45	GRIA4,GRID2,KCNJ3,GRIK2
1.166e-03	-6.75	C2	prosite domains	PS50004	142	4	12186	40	SYT1,CADPS2,RIMS2,RIMS1
1.170e-03	-6.75	export from cell	biological process	GO:0140352	485	6	18204	45	STXBP5L,CADPS2,RIMS2,SYT1,RIMS1,NRXN1
1.182e-03	-6.74	ligand-gated channel activity	molecular function	GO:0022834	187	4	18094	45	GRID2,GRIA4,KCNJ3,GRIK2
1.198e-03	-6.73	SYT1 (synaptotagmin 1)	protein interactions	6857	83	3	19454	49	NRXN1,RIMS1,SYT1
1.218e-03	-6.71	ventricular cardiac muscle cell action potential	biological process	GO:0086005	21	2	18204	45	ANK2,KCNJ3
1.222e-03	-6.71	Serotonin Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-181429	18	2	10285	30	RIMS1,SYT1
1.222e-03	-6.71	Norepinephrine Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-181430	18	2	10285	30	SYT1,RIMS1
1.224e-03	-6.71	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	43	16828	48	ZNF385B,GPC6,RIMS1,CNTN4,RELN,NRXN3,DTNA,LSAMP,SYT1,GRID2,CDH18,CADPS2,KIF21A,CHN2,SLC1A3,CACNA2D1,NRXN1,EPHA5,NPAS3,NFIA,PTPRG,ST18,GLCE,PCDH9,ANK2,ZNF385D,STXBP5L,CST3,CNTN5,LRRTM4,RALYL,RUNX1T1,NRG1,SLC35F3,CNTNAP2,LINGO2,TRPM3,NRG3,MYT1L,RIMS2,GRIA4,TLL1,FSTL5
1.225e-03	-6.70	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	47	16828	48	RIMS2,TRPM3,NRG3,RALYL,RUNX1T1,NRG1,SLC35F3,STXBP5L,LRRTM4,KCNJ3,ZNF385D,NFIA,ST18,PCDH9,NRXN1,NPAS3,CHN2,SLC1A3,GRID2,CDH18,CADPS2,KIF21A,SYT1,RELN,ZNF385B,APOE,RIMS1,EBF1,FSTL5,GRIA4,TLL1,MYT1L,LINGO2,CNTNAP2,CNTN5,GRIK2,ANK2,PTPRG,GLCE,EPHA5,CACNA2D1,NRXN3,DTNA,UNC5C,LSAMP,CNTN4,GPC6
1.225e-03	-6.70	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	47	16828	48	TRPM3,NRG3,RIMS2,RALYL,RUNX1T1,NRG1,SLC35F3,KCNJ3,ZNF385D,STXBP5L,LRRTM4,ST18,NFIA,PCDH9,CHN2,SLC1A3,NRXN1,NPAS3,SYT1,GRID2,CADPS2,CDH18,KIF21A,ZNF385B,APOE,RIMS1,RELN,GRIA4,TLL1,FSTL5,EBF1,MYT1L,CNTNAP2,LINGO2,GRIK2,ANK2,CNTN5,PTPRG,GLCE,CACNA2D1,EPHA5,NRXN3,DTNA,UNC5C,LSAMP,GPC6,CNTN4
1.238e-03	-6.69	cervix	COSMIC cancer mutations	cervix	11793	43	16828	48	NFIA,PTPRG,ST18,PCDH9,GLCE,NRXN1,EPHA5,NPAS3,CHN2,CACNA2D1,SLC1A3,GRID2,CDH18,CADPS2,KIF21A,NRXN3,DTNA,LSAMP,SYT1,CNTN4,RELN,ZNF385B,RIMS1,GPC6,FSTL5,GRIA4,TLL1,RIMS2,TRPM3,MYT1L,NRG3,LINGO2,RALYL,NRG1,RUNX1T1,CNTNAP2,SLC35F3,STXBP5L,CST3,CNTN5,LRRTM4,ZNF385D,ANK2
1.240e-03	-6.69	RAB27A (RAB27A, member RAS oncogene family)	protein interactions	5873	84	3	19454	49	SYT1,RIMS1,RIMS2
1.246e-03	-6.69	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	28	16828	48	TRPM3,NRG3,RIMS2,GRIA4,FSTL5,EBF1,GRIK2,ANK2,STXBP5L,RUNX1T1,CNTNAP2,LINGO2,CACNA2D1,SLC1A3,NRXN1,EPHA5,NFIA,PCDH9,ZNF385B,GPC6,RIMS1,RELN,NRXN3,DTNA,SYT1,GRID2,CDH18,KIF21A
1.254e-03	-6.68	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	28	16828	48	ZNF385B,GPC6,RIMS1,RELN,NRXN3,DTNA,SYT1,GRID2,CDH18,KIF21A,CACNA2D1,SLC1A3,NRXN1,EPHA5,NFIA,PCDH9,ANK2,GRIK2,STXBP5L,RUNX1T1,CNTNAP2,LINGO2,TRPM3,NRG3,RIMS2,GRIA4,FSTL5,EBF1
1.274e-03	-6.67	PDZ domain binding	molecular function	GO:0030165	86	3	18094	45	GRIK2,DTNA,GRID2
1.338e-03	-6.62	membrane depolarization during action potential	biological process	GO:0086010	22	2	18204	45	ANK2,CACNA2D1
1.364e-03	-6.60	GABA synthesis, release, reuptake and degradation	REACTOME pathways	R-HSA-888590	19	2	10285	30	RIMS1,SYT1
1.406e-03	-6.57	amyloid-beta binding	molecular function	GO:0001540	89	3	18094	45	GRIA4,CST3,APOE
1.439e-03	-6.54	channel activity	molecular function	GO:0015267	502	6	18094	45	GRIA4,GRID2,CACNA2D1,GRIK2,TRPM3,KCNJ3
1.454e-03	-6.53	passive transmembrane transporter activity	molecular function	GO:0022803	503	6	18094	45	GRID2,GRIA4,KCNJ3,TRPM3,GRIK2,CACNA2D1
1.463e-03	-6.53	ionotropic glutamate receptor signaling pathway	biological process	GO:0035235	23	2	18204	45	GRIA4,GRIK2
1.520e-03	-6.49	positive regulation of transporter activity	biological process	GO:0032411	92	3	18204	45	RELN,CACNA2D1,ANK2
1.593e-03	-6.44	postsynaptic density organization	biological process	GO:0097106	24	2	18204	45	NRXN1,RELN
1.598e-03	-6.44	regulation of transport	biological process	GO:0051049	1621	11	18204	45	RIMS1,EPHA5,RIMS2,SYT1,ANK2,CACNA2D1,KCNJ3,CADPS2,RELN,APOE,NRG1
1.612e-03	-6.43	low-density lipoprotein particle receptor binding	molecular function	GO:0050750	24	2	18094	45	APOE,SYT1
1.632e-03	-6.42	nervous system process	biological process	GO:0050877	1376	10	18204	45	NRXN3,GRIK2,RIMS1,RELN,CNTNAP2,NRXN1,SLC1A3,CNTN5,GRID2,APOE
1.714e-03	-6.37	positive regulation of developmental process	biological process	GO:0051094	1385	10	18204	45	RIMS1,LINGO2,RIMS2,RELN,UNC5C,NRXN1,SYT1,GRID2,NRG1,APOE
1.729e-03	-6.36	regulation of ventricular cardiac muscle cell membrane repolarization	biological process	GO:0060307	25	2	18204	45	ANK2,CACNA2D1
1.731e-03	-6.36	cation channel complex	cellular component	GO:0034703	205	4	19108	48	GRIK2,KCNJ3,CACNA2D1,CNTNAP2
1.765e-03	-6.34	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	9	18204	45	UNC5C,CNTNAP2,NRXN1,EPHA5,NRXN3,RELN,APOE,CNTN5,CNTN4
1.800e-03	-6.32	neurotransmitter receptor activity	molecular function	GO:0030594	97	3	18094	45	GRIA4,GRID2,GRIK2
1.817e-03	-6.31	developmental process	biological process	GO:0032502	5716	24	18204	45	CNTN4,MYT1L,FSTL5,SYT1,GRID2,EPHA5,NRXN3,RIMS2,NRXN1,CNTN5,NRG1,APOE,RELN,TLL1,CNTNAP2,LSAMP,SLC1A3,NRG3,ANK2,RIMS1,NFIA,PCDH9,UNC5C,CDH18
1.832e-03	-6.30	SHC1 events in ERBB2 signaling	REACTOME pathways	R-HSA-1250196	22	2	10285	30	NRG1,NRG3
1.863e-03	-6.29	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	11	16828	48	LINGO2,CDH18,EBF1,UNC5C,TLL1,NFIA,PTPRG,RELN,RIMS1,MYT1L,ANK2
1.863e-03	-6.29	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	11	16828	48	MYT1L,EBF1,TLL1,NFIA,PTPRG,RELN,RIMS1,ANK2,LINGO2,CDH18,UNC5C
1.875e-03	-6.28	human chr2q31.2-q31.3	chromosome location	human chr2q31.2-q31.3	1	1	26134	49	ZNF385B
1.875e-03	-6.28	human chr9p21.2-p21.1	chromosome location	human chr9p21.2-p21.1	1	1	26134	49	LINGO2
1.875e-03	-6.28	human chr13q31.3-q32.1	chromosome location	human chr13q31.3-q32.1	1	1	26134	49	GPC6
1.875e-03	-6.28	human chr4q25-q26	chromosome location	human chr4q25-q26	1	1	26134	49	ANK2
1.875e-03	-6.28	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	49	TRPM3
1.875e-03	-6.28	human chr7q35-q36.1	chromosome location	human chr7q35-q36.1	1	1	26134	49	CNTNAP2
1.875e-03	-6.28	human chr4q13.1-q13.2	chromosome location	human chr4q13.1-q13.2	1	1	26134	49	EPHA5
1.875e-03	-6.28	human chr4q22.1-q22.2	chromosome location	human chr4q22.1-q22.2	1	1	26134	49	GRID2
1.875e-03	-6.28	human chr3p26.3-p26.2	chromosome location	human chr3p26.3-p26.2	1	1	26134	49	CNTN4
1.875e-03	-6.28	human chr14q24.3-q31.1	chromosome location	human chr14q24.3-q31.1	1	1	26134	49	NRXN3
1.876e-03	-6.28	heart contraction	biological process	GO:0060047	99	3	18204	45	KCNJ3,CACNA2D1,ANK2
1.876e-03	-6.28	regulation of neurotransmitter transport	biological process	GO:0051588	99	3	18204	45	RIMS1,SYT1,RIMS2
1.909e-03	-6.26	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	48	16828	48	PCDH9,ST18,NFIA,NPAS3,NRXN1,SLC1A3,CHN2,CADPS2,CDH18,KIF21A,GRID2,SYT1,RELN,RIMS1,ZNF385B,APOE,RIMS2,NRG3,TRPM3,SLC35F3,RALYL,RUNX1T1,NRG1,CST3,LRRTM4,STXBP5L,ZNF385D,KCNJ3,GLCE,PTPRG,EPHA5,CACNA2D1,UNC5C,LSAMP,NRXN3,DTNA,CNTN4,GPC6,EBF1,FSTL5,GRIA4,TLL1,MYT1L,LINGO2,CNTNAP2,CNTN5,GRIK2,ANK2
1.909e-03	-6.26	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	48	16828	48	MYT1L,TLL1,GRIA4,FSTL5,EBF1,GRIK2,ANK2,CNTN5,CNTNAP2,LINGO2,CACNA2D1,EPHA5,PTPRG,GLCE,GPC6,CNTN4,DTNA,NRXN3,LSAMP,UNC5C,TRPM3,NRG3,RIMS2,KCNJ3,ZNF385D,STXBP5L,CST3,LRRTM4,RUNX1T1,NRG1,RALYL,SLC35F3,CHN2,SLC1A3,NRXN1,NPAS3,NFIA,ST18,PCDH9,APOE,ZNF385B,RIMS1,RELN,SYT1,GRID2,KIF21A,CADPS2,CDH18
1.909e-03	-6.26	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	48	16828	48	ANK2,GRIK2,CNTN5,CNTNAP2,LINGO2,MYT1L,GRIA4,TLL1,EBF1,FSTL5,GPC6,CNTN4,UNC5C,LSAMP,NRXN3,DTNA,CACNA2D1,EPHA5,GLCE,PTPRG,ZNF385D,KCNJ3,CST3,LRRTM4,STXBP5L,SLC35F3,RALYL,RUNX1T1,NRG1,NRG3,TRPM3,RIMS2,RIMS1,ZNF385B,APOE,RELN,SYT1,CADPS2,CDH18,KIF21A,GRID2,SLC1A3,CHN2,NPAS3,NRXN1,PCDH9,ST18,NFIA
1.909e-03	-6.26	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	48	16828	48	EPHA5,CACNA2D1,GLCE,PTPRG,CNTN4,GPC6,UNC5C,LSAMP,NRXN3,DTNA,MYT1L,FSTL5,EBF1,GRIA4,TLL1,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,NFIA,ST18,RELN,RIMS1,ZNF385B,APOE,CADPS2,CDH18,KIF21A,GRID2,SYT1,RIMS2,NRG3,TRPM3,LRRTM4,CST3,STXBP5L,ZNF385D,KCNJ3,SLC35F3,RALYL,RUNX1T1,NRG1
1.916e-03	-6.26	classic	COSMIC cancer mutations	classic	14774	48	16828	48	CNTN4,GPC6,NRXN3,DTNA,UNC5C,LSAMP,EPHA5,CACNA2D1,PTPRG,GLCE,CNTN5,ANK2,GRIK2,LINGO2,CNTNAP2,MYT1L,EBF1,FSTL5,GRIA4,TLL1,RELN,ZNF385B,APOE,RIMS1,GRID2,CADPS2,CDH18,KIF21A,SYT1,NRXN1,NPAS3,CHN2,SLC1A3,NFIA,ST18,PCDH9,STXBP5L,CST3,LRRTM4,KCNJ3,ZNF385D,RALYL,NRG1,RUNX1T1,SLC35F3,RIMS2,TRPM3,NRG3
1.930e-03	-6.25	side of membrane	cellular component	GO:0098552	715	7	19108	48	EPHA5,CNTN4,GPC6,CNTN5,LSAMP,KCNJ3,DTNA
1.941e-03	-6.24	medulla	COSMIC cancer mutations	medulla	14778	48	16828	48	SLC35F3,RUNX1T1,NRG1,RALYL,CST3,LRRTM4,STXBP5L,ZNF385D,KCNJ3,RIMS2,NRG3,TRPM3,KIF21A,CADPS2,CDH18,GRID2,SYT1,RELN,RIMS1,APOE,ZNF385B,PCDH9,NFIA,ST18,NPAS3,NRXN1,SLC1A3,CHN2,LINGO2,CNTNAP2,CNTN5,GRIK2,ANK2,EBF1,FSTL5,TLL1,GRIA4,MYT1L,LSAMP,UNC5C,DTNA,NRXN3,CNTN4,GPC6,GLCE,PTPRG,EPHA5,CACNA2D1
1.946e-03	-6.24	secretion	biological process	GO:0046903	536	6	18204	45	RIMS1,CADPS2,RIMS2,NRXN1,SYT1,STXBP5L
1.947e-03	-6.24	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	48	16828	48	KCNJ3,ZNF385D,STXBP5L,CST3,LRRTM4,RALYL,NRG1,RUNX1T1,SLC35F3,TRPM3,NRG3,RIMS2,ZNF385B,APOE,RIMS1,RELN,SYT1,GRID2,CDH18,CADPS2,KIF21A,CHN2,SLC1A3,NRXN1,NPAS3,ST18,NFIA,PCDH9,ANK2,GRIK2,CNTN5,CNTNAP2,LINGO2,MYT1L,GRIA4,TLL1,EBF1,FSTL5,GPC6,CNTN4,NRXN3,DTNA,UNC5C,LSAMP,CACNA2D1,EPHA5,PTPRG,GLCE
1.951e-03	-6.24	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	3	12186	40	EPHA5,APOE,CNTNAP2
1.964e-03	-6.23	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	3	18094	45	GRIK2,SLC1A3,GRIA4
1.986e-03	-6.22	actin filament-based movement	biological process	GO:0030048	101	3	18204	45	CACNA2D1,ANK2,KCNJ3
1.996e-03	-6.22	regulation of cell junction assembly	biological process	GO:1901888	217	4	18204	45	LINGO2,GRID2,CNTNAP2,NRXN1
2.003e-03	-6.21	Dopamine Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-212676	23	2	10285	30	SYT1,RIMS1
2.016e-03	-6.21	postsynaptic specialization organization	biological process	GO:0099084	27	2	18204	45	NRXN1,RELN
2.019e-03	-6.21	FN3_dom	interpro domains	IPR003961	203	4	18521	49	CNTN4,PTPRG,CNTN5,EPHA5
2.019e-03	-6.21	FN3_sf	interpro domains	IPR036116	203	4	18521	49	EPHA5,CNTN5,PTPRG,CNTN4
2.030e-03	-6.20	EGF-type_Asp/Asn_hydroxyl_site	interpro domains	IPR000152	95	3	18521	49	TLL1,NRXN3,NRXN1
2.085e-03	-6.17	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	48	TRPM3,NRG3,RIMS2,KCNJ3,ZNF385D,STXBP5L,LRRTM4,CST3,RUNX1T1,NRG1,RALYL,SLC35F3,CHN2,SLC1A3,NRXN1,NPAS3,NFIA,ST18,PCDH9,APOE,ZNF385B,RIMS1,RELN,SYT1,GRID2,KIF21A,CDH18,CADPS2,MYT1L,TLL1,GRIA4,EBF1,FSTL5,GRIK2,ANK2,CNTN5,CNTNAP2,LINGO2,CACNA2D1,EPHA5,PTPRG,GLCE,GPC6,CNTN4,DTNA,NRXN3,LSAMP,UNC5C
2.085e-03	-6.17	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	48	CNTN5,ANK2,GRIK2,LINGO2,CNTNAP2,MYT1L,FSTL5,EBF1,TLL1,GRIA4,CNTN4,GPC6,LSAMP,UNC5C,DTNA,NRXN3,EPHA5,CACNA2D1,GLCE,PTPRG,LRRTM4,CST3,STXBP5L,ZNF385D,KCNJ3,SLC35F3,NRG1,RUNX1T1,RALYL,RIMS2,NRG3,TRPM3,RELN,RIMS1,APOE,ZNF385B,KIF21A,CADPS2,CDH18,GRID2,SYT1,NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,ST18,NFIA
2.086e-03	-6.17	postsynaptic density membrane	cellular component	GO:0098839	101	3	19108	48	GRID2,GRIK2,GRIA4
2.086e-03	-6.17	potassium channel complex	cellular component	GO:0034705	101	3	19108	48	KCNJ3,GRIK2,CNTNAP2
2.101e-03	-6.17	regulation of heart rate	biological process	GO:0002027	103	3	18204	45	KCNJ3,ANK2,CACNA2D1
2.168e-03	-6.13	startle response	biological process	GO:0001964	28	2	18204	45	CNTNAP2,GRID2
2.181e-03	-6.13	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	15	16828	48	STXBP5L,RELN,APOE,GRIK2,GRID2,CNTNAP2,NPAS3,TRPM3,SLC1A3,MYT1L,EBF1,TLL1,ST18,NFIA,PTPRG
2.181e-03	-6.13	alveolar	COSMIC cancer mutations	alveolar	2414	15	16828	48	CNTNAP2,GRID2,GRIK2,APOE,RELN,STXBP5L,ST18,PTPRG,NFIA,TLL1,EBF1,MYT1L,SLC1A3,TRPM3,NPAS3
2.194e-03	-6.12	chemorepellent activity	molecular function	GO:0045499	28	2	18094	45	NRG1,NRG3
2.195e-03	-6.12	localization within membrane	biological process	GO:0051668	549	6	18204	45	STXBP5L,ANK2,APOE,RELN,GRIK2,NRXN1
2.219e-03	-6.11	regulation of postsynapse organization	biological process	GO:0099175	105	3	18204	45	RELN,GRID2,APOE
2.232e-03	-6.10	thyroid	COSMIC cancer mutations	thyroid	9867	38	16828	48	NRG1,RUNX1T1,RALYL,CNTNAP2,SLC35F3,LINGO2,KCNJ3,ZNF385D,ANK2,GRIK2,STXBP5L,CST3,CNTN5,LRRTM4,GRIA4,EBF1,TRPM3,NRG3,MYT1L,RIMS2,DTNA,NRXN3,SYT1,LSAMP,UNC5C,GRID2,KIF21A,RIMS1,GPC6,CNTN4,RELN,PTPRG,ST18,NFIA,PCDH9,GLCE,CACNA2D1,NRXN1
2.236e-03	-6.10	regulation of secretion by cell	biological process	GO:1903530	551	6	18204	45	SYT1,APOE,RIMS2,CADPS2,EPHA5,RIMS1
2.253e-03	-6.10	GRIK2 (glutamate ionotropic receptor kainate type subunit 2)	protein interactions	2898	28	2	19454	49	GRIK2,GRID2
2.253e-03	-6.10	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	48	16828	48	ZNF385B,APOE,RIMS1,RELN,SYT1,GRID2,CADPS2,CDH18,KIF21A,CHN2,SLC1A3,NRXN1,NPAS3,ST18,NFIA,PCDH9,KCNJ3,ZNF385D,STXBP5L,LRRTM4,CST3,RALYL,RUNX1T1,NRG1,SLC35F3,TRPM3,NRG3,RIMS2,GPC6,CNTN4,NRXN3,DTNA,UNC5C,LSAMP,CACNA2D1,EPHA5,PTPRG,GLCE,ANK2,GRIK2,CNTN5,CNTNAP2,LINGO2,MYT1L,GRIA4,TLL1,EBF1,FSTL5
2.255e-03	-6.09	monoatomic ion transport	biological process	GO:0006811	964	8	18204	45	CACNA2D1,ANK2,GRID2,GRIA4,KCNJ3,TRPM3,GRIK2,SLC1A3
2.275e-03	-6.09	cell development	biological process	GO:0048468	2236	13	18204	45	SLC1A3,NRXN1,UNC5C,CNTNAP2,RELN,NRXN3,EPHA5,NRG1,APOE,ANK2,CNTN4,CNTN5,MYT1L
2.280e-03	-6.08	regulation of postsynaptic membrane potential	biological process	GO:0060078	106	3	18204	45	GRIA4,GRIK2,GRID2
2.336e-03	-6.06	cell projection organization	biological process	GO:0030030	1200	9	18204	45	APOE,CNTN4,CNTN5,NRXN1,UNC5C,CNTNAP2,RELN,NRXN3,EPHA5
2.361e-03	-6.05	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	3	10285	30	CNTN5,LSAMP,CNTN4
2.367e-03	-6.05	Nuclear signaling by ERBB4	REACTOME pathways	R-HSA-1251985	25	2	10285	30	NRG3,NRG1
2.382e-03	-6.04	SNARE binding	molecular function	GO:0000149	107	3	18094	45	STXBP5L,GRIK2,SYT1
2.382e-03	-6.04	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	7	18094	45	GRIA4,KCNJ3,GRID2,SLC1A3,CACNA2D1,GRIK2,TRPM3
2.412e-03	-6.03	large_cell	COSMIC cancer mutations	large_cell	14845	48	16828	48	RIMS2,NRG3,TRPM3,CST3,LRRTM4,STXBP5L,ZNF385D,KCNJ3,SLC35F3,RALYL,NRG1,RUNX1T1,NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,ST18,NFIA,RELN,RIMS1,ZNF385B,APOE,CDH18,CADPS2,KIF21A,GRID2,SYT1,MYT1L,FSTL5,EBF1,GRIA4,TLL1,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,EPHA5,CACNA2D1,GLCE,PTPRG,CNTN4,GPC6,UNC5C,LSAMP,NRXN3,DTNA
2.414e-03	-6.03	skin-ankle-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-ankle-malignant_melanoma-acral_lentiginous	330	5	16828	48	NRG3,CNTNAP2,SLC35F3,RIMS2,STXBP5L
2.468e-03	-6.00	postsynapse organization	biological process	GO:0099173	109	3	18204	45	NRXN1,APOE,RELN
2.472e-03	-6.00	fast, calcium ion-dependent exocytosis of neurotransmitter	biological process	GO:0098746	1	1	18204	45	SYT1
2.472e-03	-6.00	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	45	APOE
2.472e-03	-6.00	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	45	APOE
2.472e-03	-6.00	positive regulation of lateral motor column neuron migration	biological process	GO:1902078	1	1	18204	45	RELN
2.472e-03	-6.00	synchronous neurotransmitter secretion	biological process	GO:0071911	1	1	18204	45	SYT1
2.472e-03	-6.00	regulation of motor neuron migration	biological process	GO:1905483	1	1	18204	45	RELN
2.472e-03	-6.00	detection of cold stimulus involved in thermoception	biological process	GO:0120169	1	1	18204	45	GRIK2
2.472e-03	-6.00	sensory perception of cold stimulus	biological process	GO:0062035	1	1	18204	45	GRIK2
2.472e-03	-6.00	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	45	APOE
2.472e-03	-6.00	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	45	APOE
2.472e-03	-6.00	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	45	CST3
2.472e-03	-6.00	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	45	NRG3
2.472e-03	-6.00	positive regulation of motor neuron migration	biological process	GO:1905485	1	1	18204	45	RELN
2.472e-03	-6.00	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	45	APOE
2.472e-03	-6.00	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	45	APOE
2.472e-03	-6.00	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	45	APOE
2.472e-03	-6.00	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	45	CST3
2.472e-03	-6.00	regulation of lateral motor column neuron migration	biological process	GO:1902076	1	1	18204	45	RELN
2.472e-03	-6.00	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	45	APOE
2.472e-03	-6.00	positive regulation of calcium ion-dependent exocytosis of neurotransmitter	biological process	GO:1903235	1	1	18204	45	SYT1
2.472e-03	-6.00	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	45	NRG3
2.487e-03	-6.00	netrin receptor activity involved in chemorepulsion	molecular function	GO:0005043	1	1	18094	45	UNC5C
2.487e-03	-6.00	voltage-gated calcium channel activity involved in bundle of His cell action potential	molecular function	GO:0086057	1	1	18094	45	CACNA2D1
2.487e-03	-6.00	heparosan-N-sulfate-glucuronate 5-epimerase activity	molecular function	GO:0047464	1	1	18094	45	GLCE
2.487e-03	-6.00	metal chelating activity	molecular function	GO:0046911	1	1	18094	45	APOE
2.487e-03	-6.00	regulation of cardiac muscle cell membrane repolarization	biological process	GO:0099623	30	2	18204	45	ANK2,CACNA2D1
2.499e-03	-5.99	cell adhesion molecule binding	molecular function	GO:0050839	560	6	18094	45	CNTN4,NRXN1,CDH18,NRXN3,NRG1,CNTN5
2.512e-03	-5.99	mossy fiber rosette	cellular component	GO:0097471	1	1	19108	48	GRIK2
2.512e-03	-5.99	reelin complex	cellular component	GO:0110157	1	1	19108	48	RELN
2.519e-03	-5.98	Ganab (glucosidase II alpha subunit)	protein interactions	293721	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp1a2 (ATPase Na+/K+ transporting subunit alpha 2)	protein interactions	24212	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sphkap (SPHK1 interactor, AKAP domain containing)	protein interactions	316561	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Stxbp5l (syntaxin binding protein 5L)	protein interactions	288080	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Lmnb2 (lamin B2)	protein interactions	299625	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kpna2l1 (karyopherin subunit alpha 2 like 1)	protein interactions	100359600	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ranbp2 (RAN binding protein 2)	protein interactions	294429	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kifc2 (kinesin family member C2)	protein interactions	300053	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Eif3b (eukaryotic translation initiation factor 3, subunit B)	protein interactions	288516	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sec11a (SEC11 homolog A, signal peptidase complex subunit)	protein interactions	65166	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC286987 (hemiferrin, transferrin-like protein)	protein interactions	286987	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Fstl4 (follistatin-like 4)	protein interactions	303130	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Vwa5b2 (von Willebrand factor A domain containing 5B2)	protein interactions	303812	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Srsf4 (serine and arginine rich splicing factor 4)	protein interactions	362612	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dnaaf3 (dynein, axonemal, assembly factor 3)	protein interactions	100359753	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nnt (nicotinamide nucleotide transhydrogenase)	protein interactions	310378	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Trip11 (thyroid hormone receptor interactor 11)	protein interactions	314393	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hdgfl3 (HDGF like 3)	protein interactions	252941	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rps26-ps11 (ribosomal protein S26, pseudogene 11)	protein interactions	100360508	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmga1 (high mobility group AT-hook 1)	protein interactions	117062	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Phb2 (prohibitin 2)	protein interactions	114766	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Snrnp27 (small nuclear ribonucleoprotein U4/U6.U5 subunit 27)	protein interactions	362392	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kiaa0232 (KIAA0232 homolog)	protein interactions	680039	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Stoml2 (stomatin like 2)	protein interactions	298203	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Usp15 (ubiquitin specific peptidase 15)	protein interactions	171329	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Taf15 (TATA-box binding protein associated factor 15)	protein interactions	287571	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dynll1 (dynein light chain LC8-type 1)	protein interactions	58945	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Glg1 (golgi glycoprotein 1)	protein interactions	29476	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rnf13 (ring finger protein 13)	protein interactions	681578	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hspa4 (heat shock protein family A (Hsp70) member 4)	protein interactions	266759	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgam1 (phosphoglycerate mutase 1)	protein interactions	24642	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ins2 (insulin 2)	protein interactions	24506	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hnrnph3 (heterogeneous nuclear ribonucleoprotein H3)	protein interactions	361838	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ttc22 (tetratricopeptide repeat domain 22)	protein interactions	298300	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hm13 (histocompatibility minor 13)	protein interactions	311545	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cep135 (centrosomal protein 135)	protein interactions	305288	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rab5c (RAB5C, member RAS oncogene family)	protein interactions	287709	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ptmal5 (prothymosin alpha like 5)	protein interactions	100359583	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Lrp8 (low density lipoprotein receptor-related protein 8, apolipoprotein e receptor)	protein interactions	16975	1	1	19454	49	RELN
2.519e-03	-5.98	Mroh6 (maestro heat-like repeat family member 6)	protein interactions	100359562	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC102554637 (anionic trypsin-2-like)	protein interactions	102554637	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgk2 (phosphoglycerate kinase 2)	protein interactions	316265	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gps1 (G protein pathway suppressor 1)	protein interactions	117039	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ndufb8 (NADH:ubiquinone oxidoreductase subunit B8)	protein interactions	293991	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Kif5b (kinesin family member 5B)	protein interactions	117550	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tceal3 (transcription elongation factor A like 3)	protein interactions	501628	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cplx2 (complexin 2)	protein interactions	116657	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Amz2 (archaelysin family metallopeptidase 2)	protein interactions	360650	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cyp2c55 (cytochrome P450, family 2, subfamily c, polypeptide 55)	protein interactions	100361492	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cct3 (chaperonin containing TCP1 subunit 3)	protein interactions	295230	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Fam114a2 (family with sequence similarity 114, member A2)	protein interactions	303155	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Itln1 (intelectin 1)	protein interactions	498284	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Bst2 (bone marrow stromal cell antigen 2)	protein interactions	378947	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gaa (alpha glucosidase)	protein interactions	367562	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rps12l1 (ribosomal protein S12 like 1)	protein interactions	100360573	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp6v0d1 (ATPase H+ transporting V0 subunit D1)	protein interactions	291969	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Abca4 (ATP binding cassette subfamily A member 4)	protein interactions	310836	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ptma (prothymosin alpha)	protein interactions	29222	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Syvn1 (synoviolin 1)	protein interactions	361712	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	246333	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gorasp2 (golgi reassembly stacking protein 2)	protein interactions	113961	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sel1l2 (SEL1L2 adaptor subunit of SYVN1 ubiquitin ligase)	protein interactions	311470	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ranbp1 (RAN binding protein 1)	protein interactions	360739	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atxn2 (ataxin 2)	protein interactions	288663	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sod1 (superoxide dismutase 1)	protein interactions	24786	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Vgf (VGF nerve growth factor inducible)	protein interactions	29461	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Psma3l (proteasome subunit alpha type 3-like)	protein interactions	408248	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sh3glb1 (SH3 domain -containing GRB2-like endophilin B1)	protein interactions	292156	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gpd2 (glycerol-3-phosphate dehydrogenase 2)	protein interactions	25062	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tgoln2 (trans-golgi network protein 2)	protein interactions	192152	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ndufs1 (NADH:ubiquinone oxidoreductase core subunit S1)	protein interactions	301458	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sec16a (SEC16 homolog A, endoplasmic reticulum export factor)	protein interactions	100360302	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Os9 (OS9, endoplasmic reticulum lectin)	protein interactions	362891	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Mlec (malectin)	protein interactions	304543	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Srprb (SRP receptor subunit beta)	protein interactions	300965	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cep192 (centrosomal protein 192)	protein interactions	307347	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ciao2b (cytosolic iron-sulfur assembly component 2B)	protein interactions	680987	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copb2 (COPI coat complex subunit beta 2)	protein interactions	60384	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Erbb4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	13869	1	1	19454	49	NRG1
2.519e-03	-5.98	Cul3 (cullin 3)	protein interactions	301555	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cox5b (cytochrome c oxidase subunit 5B)	protein interactions	94194	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tardbp (TAR DNA binding protein)	protein interactions	298648	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Actg2 (actin gamma 2, smooth muscle)	protein interactions	25365	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Krt8 (keratin 8)	protein interactions	25626	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nomo1 (Nodal modulator 1)	protein interactions	361578	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmgn3 (high mobility group nucleosomal binding domain 3)	protein interactions	113990	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tmem263 (transmembrane protein 263)	protein interactions	362857	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ermp1 (endoplasmic reticulum metallopeptidase 1)	protein interactions	373544	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Purb (purine rich element binding protein B)	protein interactions	498407	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sncb (synuclein, beta)	protein interactions	113893	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Scgn (secretagogin, EF-hand calcium binding protein)	protein interactions	306942	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Scg5 (secretogranin V)	protein interactions	25719	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tnpo1 (transportin 1)	protein interactions	309126	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cdc37 (cell division cycle 37, HSP90 cochaperone)	protein interactions	114562	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ccar2 (cell cycle and apoptosis regulator 2)	protein interactions	306007	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Stip1 (stress-induced phosphoprotein 1)	protein interactions	192277	1	1	19454	49	STXBP5L
2.519e-03	-5.98	U2af2 (U2 small nuclear RNA auxiliary factor 2)	protein interactions	308335	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hnrnpr (heterogeneous nuclear ribonucleoprotein R)	protein interactions	319110	1	1	19454	49	STXBP5L
2.519e-03	-5.98	C1qbp (complement C1q binding protein)	protein interactions	29681	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Trim28 (tripartite motif-containing 28)	protein interactions	116698	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rpl31-ps10 (ribosomal protein L31, pseudogene 10)	protein interactions	502887	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Phb1l1 (prohibitin 1 like 1)	protein interactions	302688	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hba-a2 (hemoglobin alpha, adult chain 2)	protein interactions	360504	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Chmp4b (charged multivesicular body protein 4B)	protein interactions	100359642	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Spcs2 (signal peptidase complex subunit 2)	protein interactions	293142	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tmed2 (transmembrane p24 trafficking protein 2)	protein interactions	65165	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dnajb11 (DnaJ heat shock protein family (Hsp40) member B11)	protein interactions	360734	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rpl17-ps1 (ribosomal protein L17, pseudogene 1)	protein interactions	499485	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dynll2 (dynein light chain LC8-type 2)	protein interactions	140734	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Psap (prosaposin)	protein interactions	25524	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cope (COPI coat complex subunit epsilon)	protein interactions	290659	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Akap7 (A-kinase anchoring protein 7)	protein interactions	361458	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tuba1c (tubulin, alpha 1C)	protein interactions	300218	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pdhb (pyruvate dehydrogenase E1 subunit beta)	protein interactions	289950	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ndufv3-ps1 (NADH:ubiquinone oxidoreductase subunit V3, pseudogene 1)	protein interactions	685005	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Anxa5 (annexin A5)	protein interactions	25673	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Arsb (arylsulfatase B)	protein interactions	25227	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dync1i2 (dynein cytoplasmic 1 intermediate chain 2)	protein interactions	116659	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ppard (peroxisome proliferator-activated receptor delta)	protein interactions	25682	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC100365839 (40S ribosomal protein S3a-like)	protein interactions	100365839	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Jpt1 (Jupiter microtubule associated homolog 1)	protein interactions	287828	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hnrnpul2 (heterogeneous nuclear ribonucleoprotein U-like 2)	protein interactions	309197	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cse1l (chromosome segregation 1 like)	protein interactions	362273	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Snrpa (small nuclear ribonucleoprotein polypeptide A)	protein interactions	292729	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tpd52l2 (TPD52 like 2)	protein interactions	296480	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Dnah17 (dynein, axonemal, heavy chain 17)	protein interactions	287845	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Babam1 (BRISC and BRCA1 A complex member 1)	protein interactions	290631	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ptms (parathymosin)	protein interactions	83801	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Krt83 (keratin 83)	protein interactions	407759	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp6v0a1 (ATPase H+ transporting V0 subunit a1)	protein interactions	29757	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgam5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase)	protein interactions	288731	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC297756 (ribosomal protein S8-like)	protein interactions	297756	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Fam114a1 (family with sequence similarity 114, member A1)	protein interactions	498366	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Zc3h13 (zinc finger CCCH type containing 13)	protein interactions	305955	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pdia6 (protein disulfide isomerase family A, member 6)	protein interactions	286906	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Rps27-ps8 (ribosomal protein S27, pseudogene 8)	protein interactions	100359517	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp5f1d (ATP synthase F1 subunit delta)	protein interactions	245965	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Zmpste24 (zinc metallopeptidase STE24)	protein interactions	313564	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tor1aip2 (torsin 1A interacting protein 2)	protein interactions	304881	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Mcm3 (minichromosome maintenance complex component 3)	protein interactions	316273	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copg1 (COPI coat complex subunit gamma 1)	protein interactions	297428	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Camk2b (calcium/calmodulin-dependent protein kinase II beta)	protein interactions	24245	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cnbp (CCHC-type zinc finger, nucleic acid binding protein)	protein interactions	64530	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmgn5b (high mobility group nucleosome binding domain 5B)	protein interactions	120097335	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cd81 (Cd81 molecule)	protein interactions	25621	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Atp5mc2 (ATP synthase membrane subunit c locus 2)	protein interactions	171082	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Hmgn2 (high mobility group nucleosomal binding domain 2)	protein interactions	114637	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Pgrmc1 (progesterone receptor membrane component 1)	protein interactions	291948	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Qpct (glutaminyl-peptide cyclotransferase)	protein interactions	313837	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Scfd1 (sec1 family domain containing 1)	protein interactions	54350	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tuba4a (tubulin, alpha 4A)	protein interactions	316531	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Grpel1 (GrpE-like 1, mitochondrial)	protein interactions	79563	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC100360522 (ribosomal protein P1-like)	protein interactions	100360522	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Cep162 (centrosomal protein 162)	protein interactions	300880	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Myef2 (myelin expression factor 2)	protein interactions	679712	1	1	19454	49	STXBP5L
2.519e-03	-5.98	LOC100361008 (Cytochrome c oxidase subunit 5A, mitochondrial-like)	protein interactions	100361008	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Tmem109 (transmembrane protein 109)	protein interactions	361732	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Marcksl1 (MARCKS-like 1)	protein interactions	81520	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Timm44 (translocase of inner mitochondrial membrane 44)	protein interactions	29635	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nudc (nuclear distribution C, dynein complex regulator)	protein interactions	29648	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Slc7a5 (solute carrier family 7 member 5)	protein interactions	50719	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Gcn1 (GCN1 activator of EIF2AK4)	protein interactions	690632	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sel1l (SEL1L adaptor subunit of SYVN1 ubiquitin ligase)	protein interactions	314352	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copa (COPI coat complex subunit alpha)	protein interactions	304978	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Copb1 (COPI coat complex subunit beta 1)	protein interactions	114023	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nolc1 (nucleolar and coiled-body phosphoprotein 1)	protein interactions	64896	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Ina (internexin neuronal intermediate filament protein, alpha)	protein interactions	24503	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Iapp (islet amyloid polypeptide)	protein interactions	24476	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Acad10 (acyl-CoA dehydrogenase family, member 10)	protein interactions	304500	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Vil1 (villin 1)	protein interactions	316521	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	49	NRXN1
2.519e-03	-5.98	Gfpt1 (glutamine fructose-6-phosphate transaminase 1)	protein interactions	297417	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Nbas (NBAS subunit of NRZ tethering complex)	protein interactions	690073	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Npm1-ps9 (nucleophosmin 1, pseudogene 9)	protein interactions	300303	1	1	19454	49	STXBP5L
2.519e-03	-5.98	Actr1a (actin related protein 1A)	protein interactions	294010	1	1	19454	49	STXBP5L
2.536e-03	-5.98	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	14	16828	48	EPHA5,EBF1,FSTL5,NFIA,PTPRG,RELN,STXBP5L,GRIK2,ANK2,KIF21A,SYT1,RUNX1T1,DTNA,NRXN3
2.564e-03	-5.97	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	17	16828	48	NRG1,RUNX1T1,NRXN3,SLC35F3,CNTNAP2,LINGO2,KIF21A,GRIK2,ZNF385D,STXBP5L,RELN,EBF1,TRPM3,CHN2,NRG3,NPAS3,EPHA5
2.564e-03	-5.97	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	17	16828	48	EBF1,NRG3,TRPM3,CHN2,NPAS3,EPHA5,CNTNAP2,SLC35F3,NRG1,RUNX1T1,NRXN3,LINGO2,KIF21A,GRIK2,ZNF385D,RELN,STXBP5L
2.614e-03	-5.95	FN3	smart domains	SM00060	149	4	9717	38	EPHA5,CNTN4,CNTN5,PTPRG
2.641e-03	-5.94	Reelin_subrepeat-B	pfam domains	PF21471	1	1	17795	47	RELN
2.641e-03	-5.94	Glce_b_sandwich	pfam domains	PF21174	1	1	17795	47	GLCE
2.641e-03	-5.94	C5-epim_C	pfam domains	PF06662	1	1	17795	47	GLCE
2.646e-03	-5.93	Reelin_subrepeat-B	interpro domains	IPR049419	1	1	18521	49	RELN
2.646e-03	-5.93	Reelin	interpro domains	IPR034968	1	1	18521	49	RELN
2.646e-03	-5.93	C5-epimerase	interpro domains	IPR039721	1	1	18521	49	GLCE
2.646e-03	-5.93	CNTN4_Ig6	interpro domains	IPR033007	1	1	18521	49	CNTN4
2.646e-03	-5.93	C5-epim_C	interpro domains	IPR010598	1	1	18521	49	GLCE
2.646e-03	-5.93	NRG1	interpro domains	IPR018250	1	1	18521	49	NRG1
2.646e-03	-5.93	CBFA2T1	interpro domains	IPR013290	1	1	18521	49	RUNX1T1
2.646e-03	-5.93	K_chnl_inward-rec_Kir3	interpro domains	IPR003274	1	1	18521	49	KCNJ3
2.646e-03	-5.93	EphA5_rcpt_lig-bd	interpro domains	IPR034277	1	1	18521	49	EPHA5
2.646e-03	-5.93	Death_UNC5C	interpro domains	IPR042154	1	1	18521	49	UNC5C
2.655e-03	-5.93	positive regulation of calcium ion transmembrane transporter activity	biological process	GO:1901021	31	2	18204	45	CACNA2D1,ANK2
2.660e-03	-5.93	Matrin/U1-like-C_Znf_C2H2	interpro domains	IPR003604	29	2	18521	49	ZNF385B,ZNF385D
2.734e-03	-5.90	heart process	biological process	GO:0003015	113	3	18204	45	CACNA2D1,ANK2,KCNJ3
2.734e-03	-5.90	regulation of regulated secretory pathway	biological process	GO:1903305	113	3	18204	45	SYT1,RIMS1,RIMS2
2.740e-03	-5.90	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	3	16828	48	FSTL5,LSAMP,NRXN3
2.788e-03	-5.88	muscle contraction	biological process	GO:0006936	238	4	18204	45	KCNJ3,DTNA,CACNA2D1,ANK2
2.827e-03	-5.87	ligand-gated ion channel signaling pathway	biological process	GO:1990806	32	2	18204	45	GRIK2,GRIA4
2.827e-03	-5.87	positive regulation of nervous system process	biological process	GO:0031646	32	2	18204	45	RIMS2,RIMS1
2.861e-03	-5.86	protein tyrosine kinase activator activity	molecular function	GO:0030296	32	2	18094	45	NRG1,NRG3
2.872e-03	-5.85	acinar_carcinoma	COSMIC cancer mutations	acinar_carcinoma	1978	13	16828	48	NRXN3,RUNX1T1,SLC35F3,CNTNAP2,LINGO2,KIF21A,ANK2,GPC6,PTPRG,ST18,TRPM3,MYT1L,EPHA5
2.872e-03	-5.85	pancreas-carcinoma-acinar_carcinoma	COSMIC cancer mutations	pancreas-carcinoma-acinar_carcinoma	1978	13	16828	48	MYT1L,TRPM3,EPHA5,ST18,PTPRG,ANK2,GPC6,CNTNAP2,SLC35F3,NRXN3,RUNX1T1,KIF21A,LINGO2
2.937e-03	-5.83	NXPH2 (neurexophilin 2)	protein interactions	11249	32	2	19454	49	PCDH9,NRXN1
2.986e-03	-5.81	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	27	16828	48	TLL1,GRIA4,FSTL5,TRPM3,NRG3,MYT1L,RUNX1T1,NRG1,LINGO2,GRIK2,ANK2,CST3,CNTN5,PTPRG,ST18,GLCE,SLC1A3,NPAS3,EPHA5,DTNA,NRXN3,UNC5C,GRID2,KIF21A,CDH18,RIMS1,RELN
2.996e-03	-5.81	regulation of cell growth	biological process	GO:0001558	401	5	18204	45	APOE,NRG3,RIMS1,SYT1,RIMS2
3.016e-03	-5.80	regulation of synapse assembly	biological process	GO:0051963	117	3	18204	45	NRXN1,GRID2,LINGO2
3.017e-03	-5.80	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	6	16828	48	RELN,NPAS3,ANK2,KCNJ3,FSTL5,CNTNAP2
3.024e-03	-5.80	Death	pfam domains	PF00531	31	2	17795	47	UNC5C,ANK2
3.032e-03	-5.80	regulation of localization	biological process	GO:0032879	2028	12	18204	45	CADPS2,RELN,RIMS2,EPHA5,RIMS1,APOE,NRG1,KCNJ3,GPC6,ANK2,CACNA2D1,SYT1
3.106e-03	-5.77	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	45	16828	48	NRXN1,NPAS3,CHN2,SLC1A3,ST18,PCDH9,RELN,ZNF385B,RIMS1,GRID2,CADPS2,CDH18,KIF21A,SYT1,RIMS2,TRPM3,NRG3,STXBP5L,LRRTM4,CST3,KCNJ3,ZNF385D,RALYL,NRG1,RUNX1T1,SLC35F3,EPHA5,CACNA2D1,PTPRG,GLCE,CNTN4,GPC6,NRXN3,UNC5C,LSAMP,MYT1L,EBF1,FSTL5,GRIA4,TLL1,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2
3.140e-03	-5.76	regulation of cell morphogenesis	biological process	GO:0022604	246	4	18204	45	SYT1,RIMS1,RIMS2,RELN
3.169e-03	-5.75	Galactose-binding domain-like	gene3d domains	2.60.120.260	97	3	14470	44	RELN,CNTNAP2,EPHA5
3.210e-03	-5.74	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	6	18094	45	GRIK2,TRPM3,CACNA2D1,SLC1A3,KCNJ3,GRIA4
3.227e-03	-5.74	forebrain development	biological process	GO:0030900	408	5	18204	45	NRG3,EPHA5,RELN,CNTNAP2,PCDH9
3.260e-03	-5.73	meninges	COSMIC cancer mutations	meninges	514	6	16828	48	RELN,RIMS2,RIMS1,KCNJ3,SLC35F3,NFIA
3.260e-03	-5.73	meningioma	COSMIC cancer mutations	meningioma	514	6	16828	48	SLC35F3,NFIA,RIMS2,RELN,RIMS1,KCNJ3
3.330e-03	-5.70	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	3	16828	48	FSTL5,NRG3,NRG1
3.346e-03	-5.70	monoatomic ion transmembrane transport	biological process	GO:0034220	804	7	18204	45	GRIK2,SLC1A3,GRID2,CACNA2D1,GRIA4,TRPM3,KCNJ3
3.376e-03	-5.69	neuron fate specification	biological process	GO:0048665	35	2	18204	45	MYT1L,NFIA
3.401e-03	-5.68	Downregulation of ERBB2 signaling	REACTOME pathways	R-HSA-8863795	30	2	10285	30	NRG1,NRG3
3.430e-03	-5.68	ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15)	protein interactions	158866	120	3	19454	49	STXBP5L,RIMS2,NRXN1
3.452e-03	-5.67	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	3	7161	22	GRIA4,KCNJ3,RIMS1
3.452e-03	-5.67	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	3	7161	22	RIMS1,KCNJ3,GRIA4
3.457e-03	-5.67	regulation of biological quality	biological process	GO:0065008	2936	15	18204	45	GPC6,GRIA4,APOE,GRIK2,RELN,CNTN4,CACNA2D1,GRID2,ANK2,KCNJ3,EPHA5,RIMS1,LINGO2,RIMS2,NRXN1
3.487e-03	-5.66	cell cortex region	cellular component	GO:0099738	35	2	19108	48	RIMS2,RIMS1
3.504e-03	-5.65	FN3	prosite domains	PS50853	192	4	12186	40	CNTN4,CNTN5,EPHA5,PTPRG
3.568e-03	-5.64	positive regulation of synaptic transmission, glutamatergic	biological process	GO:0051968	36	2	18204	45	RELN,NRXN1
3.629e-03	-5.62	HS-GAG biosynthesis	REACTOME pathways	R-HSA-2022928	31	2	10285	30	GLCE,GPC6
3.635e-03	-5.62	KIR31CHANNEL	prints domains	PR01327	1	1	5227	19	KCNJ3
3.635e-03	-5.62	NEUREGULIN	prints domains	PR01089	1	1	5227	19	NRG1
3.635e-03	-5.62	MTG8PROTEIN	prints domains	PR01876	1	1	5227	19	RUNX1T1
3.644e-03	-5.61	Znf_FYVE-rel	interpro domains	IPR017455	34	2	18521	49	RIMS2,RIMS1
3.644e-03	-5.61	Death_domain	interpro domains	IPR000488	34	2	18521	49	ANK2,UNC5C
3.714e-03	-5.60	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	48	GRIK2,ZNF385D,CACNA2D1,CNTNAP2,SYT1,ST18,NRXN3,RUNX1T1,GRID2
3.717e-03	-5.59	limbic system development	biological process	GO:0021761	126	3	18204	45	RELN,EPHA5,CNTNAP2
3.732e-03	-5.59	membrane protein complex	cellular component	GO:0098796	1261	9	19108	48	CNTNAP2,SLC1A3,CACNA2D1,STXBP5L,GRIA4,GRID2,GRIK2,KCNJ3,CDH18
3.814e-03	-5.57	postsynaptic specialization membrane	cellular component	GO:0099634	125	3	19108	48	GRIA4,GRIK2,GRID2
3.843e-03	-5.56	zf-met	pfam domains	PF12874	35	2	17795	47	ZNF385D,ZNF385B
3.879e-03	-5.55	cell-cell adhesion via plasma-membrane adhesion molecules	biological process	GO:0098742	261	4	18204	45	PCDH9,CDH18,CNTN4,GRID2
3.913e-03	-5.54	GPR183 (G protein-coupled receptor 183)	protein interactions	1880	37	2	19454	49	NRXN3,GPC6
4.101e-03	-5.50	dense core granule	cellular component	GO:0031045	38	2	19108	48	SYT1,CACNA2D1
4.162e-03	-5.48	ion binding	molecular function	GO:0043167	6007	24	18094	45	KIF21A,RIMS2,APOE,FSTL5,DTNA,PCDH9,CACNA2D1,NRXN1,EPHA5,RUNX1T1,GLCE,MYT1L,SYT1,TLL1,NRXN3,CADPS2,ST18,SLC1A3,ZNF385B,ZNF385D,RELN,CHN2,EBF1,RIMS1
4.178e-03	-5.48	long-term memory	biological process	GO:0007616	39	2	18204	45	APOE,RELN
4.187e-03	-5.48	C2	pfam domains	PF00168	123	3	17795	47	RIMS1,SYT1,RIMS2
4.251e-03	-5.46	ASX_HYDROXYL	prosite domains	PS00010	100	3	12186	40	NRXN3,TLL1,NRXN1
4.339e-03	-5.44	E (envelope protein)	protein interactions	14254599	39	2	19454	49	RIMS1,RIMS2
4.391e-03	-5.43	positive regulation of dendritic spine development	biological process	GO:0060999	40	2	18204	45	RELN,APOE
4.391e-03	-5.43	regulation of membrane repolarization	biological process	GO:0060306	40	2	18204	45	ANK2,CACNA2D1
4.650e-03	-5.37	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	5	18094	45	CACNA2D1,TRPM3,GRIK2,SLC1A3,KCNJ3
4.728e-03	-5.35	telencephalon development	biological process	GO:0021537	276	4	18204	45	CNTNAP2,RELN,NRG3,EPHA5
4.915e-03	-5.32	DEATH	smart domains	SM00005	27	2	9717	38	ANK2,UNC5C
4.938e-03	-5.31	protein localization to M-band	biological process	GO:0036309	2	1	18204	45	ANK2
4.938e-03	-5.31	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	45	CST3
4.938e-03	-5.31	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	45	CST3
4.938e-03	-5.31	superior temporal gyrus development	biological process	GO:0071109	2	1	18204	45	CNTNAP2
4.938e-03	-5.31	protein localization to T-tubule	biological process	GO:0036371	2	1	18204	45	ANK2
4.938e-03	-5.31	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	45	APOE
4.955e-03	-5.31	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	3	16828	48	DTNA,CNTN5,RELN
4.968e-03	-5.30	extracellularly glutamate-gated ion channel activity	molecular function	GO:0005234	2	1	18094	45	GRIK2
4.968e-03	-5.30	syntaxin-3 binding	molecular function	GO:0030348	2	1	18094	45	SYT1
5.018e-03	-5.29	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	48	APOE
5.018e-03	-5.29	chylomicron remnant	cellular component	GO:0034360	2	1	19108	48	APOE
5.018e-03	-5.29	GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)	protein interactions	2891	42	2	19454	49	GRIK2,GRID2
5.018e-03	-5.29	FGF1 (fibroblast growth factor 1)	protein interactions	2246	42	2	19454	49	SYT1,GPC6
5.031e-03	-5.29	Plec (plectin)	protein interactions	64204	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Lrrfip2 (LRR binding FLII interacting protein 2)	protein interactions	301035	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tpm4 (tropomyosin 4)	protein interactions	24852	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	65028	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Gnb1 (G protein subunit beta 1)	protein interactions	24400	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Mfap1a (microfibrillar-associated protein 1A)	protein interactions	499878	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Eif4b (eukaryotic translation initiation factor 4B)	protein interactions	300253	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ndufv3 (NADH:ubiquinone oxidoreductase subunit V3)	protein interactions	64539	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Sec31a (SEC31 homolog A, COPII coat complex component)	protein interactions	93646	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Mycbp (Myc binding protein)	protein interactions	100361133	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Cox4i1 (cytochrome c oxidase subunit 4i1)	protein interactions	29445	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Sytl4 (synaptotagmin-like 4)	protein interactions	140594	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Chchd3 (coiled-coil-helix-coiled-coil-helix domain containing 3)	protein interactions	296966	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Thy1 (Thy-1 cell surface antigen)	protein interactions	24832	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Eef1b2 (eukaryotic translation elongation factor 1 beta 2)	protein interactions	363241	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ckap4 (cytoskeleton-associated protein 4)	protein interactions	362859	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Lmo7 (LIM domain 7)	protein interactions	361084	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rab3a (RAB3A, member RAS oncogene family)	protein interactions	25531	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Nucb1 (nucleobindin 1)	protein interactions	84595	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Myo18a (myosin XVIIIa)	protein interactions	360570	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tnpo2 (transportin 2)	protein interactions	304670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ncl (nucleolin)	protein interactions	25135	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ndufv2 (NADH:ubiquinone oxidoreductase core subunit V2)	protein interactions	81728	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Gsn (gelsolin)	protein interactions	296654	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Hadha (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha)	protein interactions	170670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Myl12b (myosin light chain 12B)	protein interactions	50685	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tcp1 (t-complex 1)	protein interactions	24818	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Atp5pd (ATP synthase peripheral stalk subunit d)	protein interactions	641434	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Dnaja2 (DnaJ heat shock protein family (Hsp40) member A2)	protein interactions	84026	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Dbn1 (drebrin 1)	protein interactions	81653	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Psmd3 (proteasome 26S subunit, non-ATPase 3)	protein interactions	287670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Psma3 (proteasome 20S subunit alpha 3)	protein interactions	29670	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rplp1 (ribosomal protein lateral stalk subunit P1)	protein interactions	140661	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Atp5pf (ATP synthase peripheral stalk subunit F6)	protein interactions	94271	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Ubap2l (ubiquitin associated protein 2-like)	protein interactions	361984	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tmod3 (tropomodulin 3)	protein interactions	300838	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rab5b (RAB5B, member RAS oncogene family)	protein interactions	288779	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rpsa (ribosomal protein SA)	protein interactions	29236	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Prdx2 (peroxiredoxin 2)	protein interactions	29338	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Tufm (Tu translation elongation factor, mitochondrial)	protein interactions	293481	2	1	19454	49	STXBP5L
5.031e-03	-5.29	Rcn1 (reticulocalbin 1)	protein interactions	362182	2	1	19454	49	STXBP5L
5.225e-03	-5.25	hippocampal mossy fiber to CA3 synapse	cellular component	GO:0098686	43	2	19108	48	GRIK2,SYT1
5.276e-03	-5.24	Lgl_C	pfam domains	PF08596	2	1	17795	47	STXBP5L
5.276e-03	-5.24	Neuregulin	pfam domains	PF02158	2	1	17795	47	NRG1
5.284e-03	-5.24	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	49	PTPRG
5.284e-03	-5.24	Neuregulin_C	interpro domains	IPR002154	2	1	18521	49	NRG1
5.284e-03	-5.24	Solute_c_fam_35_mem_F3/F4	interpro domains	IPR026505	2	1	18521	49	SLC35F3
5.284e-03	-5.24	Chimaerin_SH2	interpro domains	IPR035840	2	1	18521	49	CHN2
5.284e-03	-5.24	CAPS	interpro domains	IPR033227	2	1	18521	49	CADPS2
5.284e-03	-5.24	RhoGAP_chimaerin	interpro domains	IPR037860	2	1	18521	49	CHN2
5.284e-03	-5.24	CHN1/CHN2	interpro domains	IPR017356	2	1	18521	49	CHN2
5.284e-03	-5.24	Distrobrevin	interpro domains	IPR017432	2	1	18521	49	DTNA
5.284e-03	-5.24	Lgl_C_dom	interpro domains	IPR013905	2	1	18521	49	STXBP5L
5.284e-03	-5.24	CCSER	interpro domains	IPR029627	2	1	18521	49	CCSER1
5.362e-03	-5.23	ankle	COSMIC cancer mutations	ankle	398	5	16828	48	STXBP5L,RIMS2,NRG3,SLC35F3,CNTNAP2
5.402e-03	-5.22	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	11	16828	48	LINGO2,CDH18,GRID2,FSTL5,EBF1,SYT1,NRG1,NRXN3,NPAS3,RELN,TRPM3
5.459e-03	-5.21	protein localization to membrane	biological process	GO:0072657	462	5	18204	45	GRIK2,ANK2,RELN,APOE,NRXN1
5.515e-03	-5.20	ZF_FYVE	prosite domains	PS50178	34	2	12186	40	RIMS2,RIMS1
5.597e-03	-5.19	GPM6A (glycoprotein M6A)	protein interactions	2823	143	3	19454	49	ANK2,CACNA2D1,SYT1
5.606e-03	-5.18	adult behavior	biological process	GO:0030534	146	3	18204	45	NRXN1,CNTNAP2,NRXN3
5.657e-03	-5.17	ZnF_U1	smart domains	SM00451	29	2	9717	38	ZNF385D,ZNF385B
5.664e-03	-5.17	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	39	16828	48	PTPRG,ST18,PCDH9,NRXN1,EPHA5,NPAS3,CHN2,CACNA2D1,SLC1A3,GRID2,CADPS2,KIF21A,NRXN3,DTNA,UNC5C,SYT1,LSAMP,RELN,ZNF385B,GPC6,RIMS1,FSTL5,EBF1,GRIA4,TLL1,RIMS2,TRPM3,NRG3,MYT1L,LINGO2,RALYL,NRG1,SLC35F3,CNTNAP2,STXBP5L,KCNJ3,ZNF385D,GRIK2,ANK2
5.694e-03	-5.17	positive regulation of cellular component organization	biological process	GO:0051130	1122	8	18204	45	LINGO2,RELN,CNTNAP2,NRXN1,SYT1,GRID2,APOE,NRG1
5.704e-03	-5.17	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	43	16828	48	NFIA,ST18,PCDH9,CHN2,SLC1A3,NRXN1,NPAS3,SYT1,GRID2,CADPS2,CDH18,KIF21A,ZNF385B,RIMS1,RELN,TRPM3,NRG3,RALYL,NRG1,RUNX1T1,SLC35F3,KCNJ3,ZNF385D,STXBP5L,LRRTM4,PTPRG,GLCE,CACNA2D1,EPHA5,NRXN3,UNC5C,LSAMP,GPC6,GRIA4,TLL1,FSTL5,EBF1,MYT1L,CNTNAP2,LINGO2,ANK2,GRIK2,CNTN5
5.771e-03	-5.15	neuron recognition	biological process	GO:0008038	46	2	18204	45	CNTN4,CNTNAP2
5.826e-03	-5.15	Activation of Na-permeable Kainate Receptors	REACTOME pathways	R-HSA-451307	2	1	10285	30	GRIK2
5.885e-03	-5.14	-	gene3d domains	2.60.120.200	121	3	14470	44	NRXN1,CNTNAP2,NRXN3
5.946e-03	-5.12	spleen	COSMIC cancer mutations	spleen	408	5	16828	48	TLL1,KCNJ3,CACNA2D1,ANK2,GRID2
6.018e-03	-5.11	regulation of long-term synaptic potentiation	biological process	GO:1900271	47	2	18204	45	RELN,APOE
6.044e-03	-5.11	positive regulation of nervous system development	biological process	GO:0051962	296	4	18204	45	LINGO2,RELN,GRID2,NRXN1
6.107e-03	-5.10	pseudomyxoma_peritonei	COSMIC cancer mutations	pseudomyxoma_peritonei	585	6	16828	48	LINGO2,NRG1,PTPRG,RIMS1,CNTNAP2,ANK2
6.107e-03	-5.10	peritoneum-appendix-other-pseudomyxoma_peritonei	COSMIC cancer mutations	peritoneum-appendix-other-pseudomyxoma_peritonei	585	6	16828	48	ANK2,RIMS1,CNTNAP2,PTPRG,NRG1,LINGO2
6.116e-03	-5.10	muscle system process	biological process	GO:0003012	297	4	18204	45	CACNA2D1,ANK2,DTNA,KCNJ3
6.157e-03	-5.09	appendix	COSMIC cancer mutations	appendix	586	6	16828	48	ANK2,RIMS1,LINGO2,PTPRG,NRG1,CNTNAP2
6.207e-03	-5.08	peritoneum	COSMIC cancer mutations	peritoneum	587	6	16828	48	LINGO2,RIMS1,CNTNAP2,ANK2,NRG1,PTPRG
6.250e-03	-5.08	SLC34A2 (solute carrier family 34 member 2)	protein interactions	10568	47	2	19454	49	CACNA2D1,LINGO2
6.277e-03	-5.07	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	12	NRG1,NRG3
6.277e-03	-5.07	Apoptosis-related network due to altered Notch3 in ovarian cancer	WikiPathways	WP2864	54	2	5310	12	APOE,NRG1
6.412e-03	-5.05	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	48	16828	48	GPC6,CNTN4,UNC5C,LSAMP,NRXN3,DTNA,CACNA2D1,EPHA5,GLCE,PTPRG,GRIK2,ANK2,CNTN5,CNTNAP2,LINGO2,MYT1L,GRIA4,TLL1,EBF1,FSTL5,RIMS1,ZNF385B,APOE,RELN,SYT1,CADPS2,CDH18,KIF21A,GRID2,SLC1A3,CHN2,NPAS3,NRXN1,PCDH9,ST18,NFIA,ZNF385D,KCNJ3,CST3,LRRTM4,STXBP5L,SLC35F3,RALYL,RUNX1T1,NRG1,NRG3,TRPM3,RIMS2
6.497e-03	-5.04	small molecule binding	molecular function	GO:0036094	6197	24	18094	45	NRXN1,CACNA2D1,EPHA5,RUNX1T1,KIF21A,RIMS2,FSTL5,APOE,DTNA,PCDH9,SLC1A3,ZNF385D,ZNF385B,RELN,CHN2,RIMS1,EBF1,GLCE,MYT1L,SYT1,ST18,CADPS2,NRXN3,TLL1
6.527e-03	-5.03	positive regulation of cation channel activity	biological process	GO:2001259	49	2	18204	45	CACNA2D1,ANK2
6.550e-03	-5.03	PAS domain	gene3d domains	3.30.450.20	40	2	14470	44	CACNA2D1,NPAS3
6.568e-03	-5.03	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	6	16828	48	STXBP5L,GRIK2,MYT1L,ST18,PTPRG,NRG1
6.573e-03	-5.02	import into cell	biological process	GO:0098657	687	6	18204	45	APOE,SLC1A3,KCNJ3,ANK2,CACNA2D1,SYT1
6.579e-03	-5.02	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	10	16828	48	EBF1,CNTNAP2,TLL1,ST18,RELN,RIMS2,NRXN1,MYT1L,GPC6,ANK2
6.579e-03	-5.02	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	10	16828	48	ST18,TLL1,CNTNAP2,EBF1,ANK2,GPC6,MYT1L,NRXN1,RIMS2,RELN
6.579e-03	-5.02	calcium ion binding	molecular function	GO:0005509	683	6	18094	45	GLCE,NRXN1,FSTL5,SYT1,PCDH9,TLL1
6.613e-03	-5.02	positive regulation of monoatomic ion transmembrane transport	biological process	GO:0034767	155	3	18204	45	ANK2,CACNA2D1,RELN
6.640e-03	-5.01	bone-femur-chondrosarcoma	COSMIC cancer mutations	bone-femur-chondrosarcoma	419	5	16828	48	UNC5C,ST18,ZNF385B,STXBP5L,CNTN4
6.678e-03	-5.01	central_nervous_system-thalamus-glioma-oligoastrocytoma_Grade_II	COSMIC cancer mutations	central_nervous_system-thalamus-glioma-oligoastrocytoma_Grade_II	43	2	16828	48	DTNA,RELN
6.687e-03	-5.01	cell surface	cellular component	GO:0009986	896	7	19108	48	GPC6,SLC1A3,EPHA5,UNC5C,CNTNAP2,KCNJ3,NRXN1
6.794e-03	-4.99	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	265	4	16828	48	EBF1,RELN,NRXN3,UNC5C
6.835e-03	-4.99	protein localization	biological process	GO:0008104	1954	11	18204	45	RIMS2,RIMS1,NRXN1,ANK2,GRID2,STXBP5L,RELN,CADPS2,GRIK2,CNTNAP2,APOE
6.896e-03	-4.98	Signaling by ERBB4	REACTOME pathways	R-HSA-1236394	43	2	10285	30	NRG3,NRG1
6.929e-03	-4.97	regulation of developmental process	biological process	GO:0050793	2540	13	18204	45	RELN,UNC5C,APOE,NRG1,RIMS2,LINGO2,RIMS1,NRXN1,CST3,GRID2,SYT1,CNTN4,RUNX1T1
6.987e-03	-4.96	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	9	16828	48	GRID2,CDH18,CNTNAP2,RELN,RIMS2,TRPM3,ZNF385B,GPC6,ZNF385D
7.046e-03	-4.96	cellular macromolecule localization	biological process	GO:0070727	1962	11	18204	45	NRXN1,CNTNAP2,RIMS2,RELN,CADPS2,GRIK2,RIMS1,APOE,GRID2,ANK2,STXBP5L
7.054e-03	-4.95	neuromuscular process controlling balance	biological process	GO:0050885	51	2	18204	45	NRXN1,SLC1A3
7.157e-03	-4.94	angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	angioimmunoblastic_T_cell_lymphoma	269	4	16828	48	NRXN3,UNC5C,EBF1,RELN
7.211e-03	-4.93	Retinoid metabolism and transport	REACTOME pathways	R-HSA-975634	44	2	10285	30	APOE,GPC6
7.284e-03	-4.92	neck	COSMIC cancer mutations	neck	1231	9	16828	48	RELN,RIMS2,GPC6,ZNF385D,TRPM3,ZNF385B,CDH18,GRID2,CNTNAP2
7.341e-03	-4.91	positive regulation of cell growth	biological process	GO:0030307	161	3	18204	45	SYT1,RIMS1,RIMS2
7.398e-03	-4.91	positive regulation of synaptic vesicle exocytosis	biological process	GO:2000302	3	1	18204	45	SYT1
7.398e-03	-4.91	regulation of SA node cell action potential	biological process	GO:0098907	3	1	18204	45	ANK2
7.398e-03	-4.91	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	45	NRXN1
7.398e-03	-4.91	calcium ion transmembrane transport via high voltage-gated calcium channel	biological process	GO:0061577	3	1	18204	45	CACNA2D1
7.398e-03	-4.91	lateral motor column neuron migration	biological process	GO:0097477	3	1	18204	45	RELN
7.398e-03	-4.91	membrane depolarization during bundle of His cell action potential	biological process	GO:0086048	3	1	18204	45	CACNA2D1
7.398e-03	-4.91	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	45	APOE
7.398e-03	-4.91	regulation of synaptic activity	biological process	GO:0060025	3	1	18204	45	RELN
7.398e-03	-4.91	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	45	APOE
7.398e-03	-4.91	mammary placode formation	biological process	GO:0060596	3	1	18204	45	NRG3
7.411e-03	-4.90	cell-cell adhesion mediator activity	molecular function	GO:0098632	52	2	18094	45	CNTN5,CNTN4
7.421e-03	-4.90	regulation of developmental growth	biological process	GO:0048638	314	4	18204	45	RIMS2,RIMS1,SYT1,APOE
7.479e-03	-4.90	human chr5p14.3	chromosome location	human chr5p14.3	4	1	26134	49	CDH18
7.518e-03	-4.89	clathrin-sculpted acetylcholine transport vesicle membrane	cellular component	GO:0060201	3	1	19108	48	SYT1
7.518e-03	-4.89	clathrin-sculpted acetylcholine transport vesicle	cellular component	GO:0060200	3	1	19108	48	SYT1
7.538e-03	-4.89	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	49	NRXN1
7.538e-03	-4.89	Rps26 (ribosomal protein S26)	protein interactions	27139	3	1	19454	49	STXBP5L
7.538e-03	-4.89	Tpm1 (tropomyosin 1)	protein interactions	24851	3	1	19454	49	STXBP5L
7.538e-03	-4.89	NAB2 (mRNA-binding protein NAB2)	protein interactions	852755	3	1	19454	49	RALYL
7.538e-03	-4.89	PRDM12 (PR/SET domain 12)	protein interactions	59335	3	1	19454	49	RUNX1T1
7.538e-03	-4.89	SHF (Src homology 2 domain containing F)	protein interactions	90525	3	1	19454	49	CHN2
7.538e-03	-4.89	Vcp (valosin-containing protein)	protein interactions	116643	3	1	19454	49	STXBP5L
7.556e-03	-4.89	anatomical structure development	biological process	GO:0048856	5207	21	18204	45	SLC1A3,LSAMP,CDH18,TLL1,UNC5C,CNTNAP2,RELN,NRG1,APOE,PCDH9,CNTN5,NRXN1,NFIA,EPHA5,NRXN3,ANK2,GRID2,CNTN4,NRG3,FSTL5,MYT1L
7.677e-03	-4.87	HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha)	protein interactions	3030	491	5	19454	49	APOE,NRXN3,EPHA5,GPC6,KIF21A
7.851e-03	-4.85	homophilic cell adhesion via plasma membrane adhesion molecules	biological process	GO:0007156	165	3	18204	45	CNTN4,PCDH9,CDH18
7.851e-03	-4.85	import across plasma membrane	biological process	GO:0098739	165	3	18204	45	CACNA2D1,SLC1A3,KCNJ3
7.884e-03	-4.84	cell surface receptor signaling pathway	biological process	GO:0007166	1992	11	18204	45	GRIK2,RELN,UNC5C,PTPRG,ST18,NRG1,GRIA4,EPHA5,NFIA,NRG3,GRID2
7.903e-03	-4.84	NHR2	pfam domains	PF08788	3	1	17795	47	RUNX1T1
7.903e-03	-4.84	UPA_2	pfam domains	PF17809	3	1	17795	47	ANK2
7.916e-03	-4.84	NHR2	interpro domains	IPR014896	3	1	18521	49	RUNX1T1
7.916e-03	-4.84	Ankyrin_UPA	interpro domains	IPR040745	3	1	18521	49	ANK2
7.916e-03	-4.84	Reeler_dom	interpro domains	IPR002861	3	1	18521	49	RELN
7.916e-03	-4.84	BMP_1/tolloid-like	interpro domains	IPR015446	3	1	18521	49	TLL1
7.916e-03	-4.84	Reeler_sf	interpro domains	IPR042307	3	1	18521	49	RELN
7.916e-03	-4.84	ZnMP_TLD/BMP1	interpro domains	IPR034036	3	1	18521	49	TLL1
7.916e-03	-4.84	CBFA2T1/2/3	interpro domains	IPR013289	3	1	18521	49	RUNX1T1
8.085e-03	-4.82	circulatory system process	biological process	GO:0003013	508	5	18204	45	SLC1A3,APOE,KCNJ3,CACNA2D1,ANK2
8.116e-03	-4.81	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	6	18094	45	CACNA2D1,GRIK2,TRPM3,SLC1A3,KCNJ3,GRIA4
8.165e-03	-4.81	membrane depolarization	biological process	GO:0051899	55	2	18204	45	CACNA2D1,ANK2
8.181e-03	-4.81	PLTP (phospholipid transfer protein)	protein interactions	5360	54	2	19454	49	APOE,GPC6
8.248e-03	-4.80	positive regulation of developmental growth	biological process	GO:0048639	168	3	18204	45	RIMS1,SYT1,RIMS2
8.288e-03	-4.79	ear	COSMIC cancer mutations	ear	624	6	16828	48	FSTL5,RELN,NPAS3,KCNJ3,CNTNAP2,ANK2
8.476e-03	-4.77	large_intestine-colon-adenoma	COSMIC cancer mutations	large_intestine-colon-adenoma	627	6	16828	48	CNTN5,CACNA2D1,CNTNAP2,GRIK2,RUNX1T1,ZNF385B
8.550e-03	-4.76	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	5	18204	45	CNTNAP2,NRXN1,NRG1,LINGO2,GRID2
8.594e-03	-4.76	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME pathways	R-HSA-112314	146	3	10285	30	KCNJ3,GRIA4,GRIK2
8.618e-03	-4.75	regulation of vesicle-mediated transport	biological process	GO:0060627	516	5	18204	45	APOE,CADPS2,RIMS2,SYT1,RIMS1
8.630e-03	-4.75	thalamus	COSMIC cancer mutations	thalamus	284	4	16828	48	RELN,EBF1,DTNA,GRIA4
8.726e-03	-4.74	Toxicity of botulinum toxin type G (BoNT/G)	REACTOME pathways	R-HSA-5250989	3	1	10285	30	SYT1
8.726e-03	-4.74	Toxicity of botulinum toxin type B (BoNT/B)	REACTOME pathways	R-HSA-5250958	3	1	10285	30	SYT1
8.776e-03	-4.74	CSTL1 (cystatin like 1)	protein interactions	128817	56	2	19454	49	NRXN3,APOE
9.046e-03	-4.71	regulation of neuronal synaptic plasticity	biological process	GO:0048168	58	2	18204	45	GRIK2,APOE
9.085e-03	-4.70	monoatomic cation channel activity	molecular function	GO:0005261	331	4	18094	45	CACNA2D1,GRIK2,TRPM3,KCNJ3
9.093e-03	-4.70	Cell adhesion molecules (CAMs)	KEGG pathways	ko04514	143	3	7161	22	NRXN3,NRXN1,CNTNAP2
9.093e-03	-4.70	Cell adhesion molecules (CAMs)	KEGG pathways	hsa04514	143	3	7161	22	NRXN1,NRXN3,CNTNAP2
9.095e-03	-4.70	-	gene3d domains	2.60.40.2660	3	1	14470	44	ANK2
9.095e-03	-4.70	Reeler domain	gene3d domains	2.60.40.4060	3	1	14470	44	RELN
9.172e-03	-4.69	MAPT (microtubule associated protein tau)	protein interactions	4137	948	7	19454	49	ANK2,SYT1,RIMS1,KIF21A,LSAMP,SLC1A3,APOE
9.225e-03	-4.69	transporter activity	molecular function	GO:0005215	1211	8	18094	45	GRIA4,KCNJ3,APOE,GRID2,SLC1A3,CACNA2D1,GRIK2,TRPM3
9.293e-03	-4.68	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_II	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_II	51	2	16828	48	CNTN5,RELN
9.315e-03	-4.68	nodular	COSMIC cancer mutations	nodular	1515	10	16828	48	GRIK2,RELN,NPAS3,CNTN4,TLL1,ST18,KIF21A,CDH18,GRID2,EBF1
9.340e-03	-4.67	human chr6q16.3	chromosome location	human chr6q16.3	5	1	26134	49	GRIK2
9.349e-03	-4.67	protein localization to synapse	biological process	GO:0035418	59	2	18204	45	RELN,NRXN1
9.349e-03	-4.67	regulation of dendritic spine development	biological process	GO:0060998	59	2	18204	45	RELN,APOE
9.364e-03	-4.67	signaling receptor activity	molecular function	GO:0038023	1474	9	18094	45	NRXN1,GRIK2,GPC6,EPHA5,GRID2,UNC5C,PTPRG,GRIA4,NRXN3
9.364e-03	-4.67	molecular transducer activity	molecular function	GO:0060089	1474	9	18094	45	UNC5C,PTPRG,GRIA4,NRXN3,GRIK2,NRXN1,GPC6,GRID2,EPHA5
9.390e-03	-4.67	SNAP25 (synaptosome associated protein 25)	protein interactions	6616	58	2	19454	49	SYT1,RIMS1
9.391e-03	-4.67	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	46	16828	48	GLCE,PTPRG,CACNA2D1,EPHA5,UNC5C,LSAMP,NRXN3,DTNA,GPC6,CNTN4,GRIA4,TLL1,EBF1,FSTL5,MYT1L,CNTNAP2,LINGO2,ANK2,GRIK2,CNTN5,PCDH9,NFIA,ST18,SLC1A3,CHN2,NPAS3,NRXN1,SYT1,CDH18,CADPS2,KIF21A,GRID2,RIMS1,ZNF385B,RELN,NRG3,TRPM3,RIMS2,SLC35F3,RALYL,RUNX1T1,NRG1,ZNF385D,KCNJ3,LRRTM4,STXBP5L
9.597e-03	-4.65	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	2	10285	30	NRG1,NRG3
9.656e-03	-4.64	regulation of action potential	biological process	GO:0098900	60	2	18204	45	ANK2,CACNA2D1
9.656e-03	-4.64	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	45	CNTNAP2,GRIK2
9.769e-03	-4.63	syntaxin binding	molecular function	GO:0019905	60	2	18094	45	STXBP5L,SYT1
9.813e-03	-4.62	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	7	16828	48	SYT1,SLC35F3,CNTNAP2,NRG1,TLL1,NRXN3,EPHA5
9.813e-03	-4.62	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	7	16828	48	EPHA5,NRXN3,NRG1,TLL1,SLC35F3,CNTNAP2,SYT1
9.816e-03	-4.62	REELIN	prosite domains	PS51019	3	1	12186	40	RELN
9.834e-03	-4.62	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	9	16828	48	KIF21A,EBF1,GRID2,ST18,TLL1,RELN,NPAS3,CNTN4,GRIK2
9.852e-03	-4.62	positive regulation of synaptic vesicle fusion to presynaptic active zone membrane	biological process	GO:0031632	4	1	18204	45	SYT1
9.852e-03	-4.62	positive regulation of AMPA receptor activity	biological process	GO:2000969	4	1	18204	45	RELN
9.852e-03	-4.62	regulation of calcium ion-dependent exocytosis of neurotransmitter	biological process	GO:1903233	4	1	18204	45	SYT1
9.852e-03	-4.62	spinal cord motor neuron migration	biological process	GO:0097476	4	1	18204	45	RELN
9.852e-03	-4.62	positive regulation of high voltage-gated calcium channel activity	biological process	GO:1901843	4	1	18204	45	CACNA2D1
9.852e-03	-4.62	regulation of atrial cardiac muscle cell action potential	biological process	GO:0098910	4	1	18204	45	ANK2
9.852e-03	-4.62	response to caloric restriction	biological process	GO:0061771	4	1	18204	45	APOE
9.852e-03	-4.62	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	45	APOE
9.852e-03	-4.62	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	45	APOE
9.852e-03	-4.62	response to methylmercury	biological process	GO:0051597	4	1	18204	45	ANK2
9.852e-03	-4.62	calcium-dependent activation of synaptic vesicle fusion	biological process	GO:0099502	4	1	18204	45	SYT1
9.852e-03	-4.62	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	45	CST3
9.852e-03	-4.62	protein localization to juxtaparanode region of axon	biological process	GO:0071205	4	1	18204	45	CNTNAP2
9.852e-03	-4.62	clustering of voltage-gated potassium channels	biological process	GO:0045163	4	1	18204	45	CNTNAP2
9.852e-03	-4.62	positive regulation of synaptic vesicle membrane organization	biological process	GO:1901634	4	1	18204	45	SYT1
9.912e-03	-4.61	calcium ion sensor activity	molecular function	GO:0061891	4	1	18094	45	SYT1
9.912e-03	-4.61	AMPA glutamate receptor activity	molecular function	GO:0004971	4	1	18094	45	GRIA4
9.912e-03	-4.61	voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization	molecular function	GO:0086089	4	1	18094	45	KCNJ3
9.912e-03	-4.61	G-protein activated inward rectifier potassium channel activity	molecular function	GO:0015467	4	1	18094	45	KCNJ3
9.963e-03	-4.61	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	156	3	16828	48	GRIK2,NRXN3,EBF1
1.001e-02	-4.60	clathrin-sculpted glutamate transport vesicle membrane	cellular component	GO:0060203	4	1	19108	48	SYT1
1.001e-02	-4.60	clathrin-sculpted glutamate transport vesicle	cellular component	GO:0060199	4	1	19108	48	SYT1
1.001e-02	-4.60	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	48	APOE
1.004e-02	-4.60	Ywhaq (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta)	protein interactions	25577	4	1	19454	49	STXBP5L
1.004e-02	-4.60	CALY (calcyon neuron specific vesicular protein)	protein interactions	50632	4	1	19454	49	NRG1
1.004e-02	-4.60	Psmc5 (proteasome 26S subunit, ATPase 5)	protein interactions	81827	4	1	19454	49	STXBP5L
1.004e-02	-4.60	Baz2b (bromodomain adjacent to zinc finger domain, 2B)	protein interactions	407823	4	1	19454	49	CACNA2D1
1.004e-02	-4.60	Clta (clathrin, light chain A)	protein interactions	83800	4	1	19454	49	STXBP5L
1.004e-02	-4.60	Map1b (microtubule-associated protein 1B)	protein interactions	29456	4	1	19454	49	STXBP5L
1.010e-02	-4.60	negative regulation of cell projection organization	biological process	GO:0031345	181	3	18204	45	APOE,PTPRG,GLCE
1.020e-02	-4.59	transport	biological process	GO:0006810	3615	16	18204	45	NRXN1,RIMS1,RIMS2,KCNJ3,SYT1,GRID2,STXBP5L,ANK2,CACNA2D1,SLC35F3,SLC1A3,GRIK2,CADPS2,TRPM3,APOE,GRIA4
1.028e-02	-4.58	telencephalon cell migration	biological process	GO:0022029	62	2	18204	45	RELN,NRG3
1.034e-02	-4.57	Metabolism of fat-soluble vitamins	REACTOME pathways	R-HSA-6806667	53	2	10285	30	APOE,GPC6
1.035e-02	-4.57	OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF)	protein interactions	84033	61	2	19454	49	ANK2,SLC1A3
1.045e-02	-4.56	regulation of monoatomic ion transmembrane transport	biological process	GO:0034765	347	4	18204	45	KCNJ3,RELN,CACNA2D1,ANK2
1.052e-02	-4.55	COE1_HLH	pfam domains	PF16423	4	1	17795	47	EBF1
1.052e-02	-4.55	COE1_DBD	pfam domains	PF16422	4	1	17795	47	EBF1
1.052e-02	-4.55	Apolipoprotein	pfam domains	PF01442	4	1	17795	47	APOE
1.052e-02	-4.55	CTF_NFI	pfam domains	PF00859	4	1	17795	47	NFIA
1.052e-02	-4.55	VGCC_alpha2	pfam domains	PF08473	4	1	17795	47	CACNA2D1
1.052e-02	-4.55	LLGL	pfam domains	PF08366	4	1	17795	47	STXBP5L
1.052e-02	-4.55	VWA_N	pfam domains	PF08399	4	1	17795	47	CACNA2D1
1.052e-02	-4.55	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	47	NFIA
1.052e-02	-4.55	TRPM_tetra	pfam domains	PF16519	4	1	17795	47	TRPM3
1.054e-02	-4.55	Lethal2_giant	interpro domains	IPR000664	4	1	18521	49	STXBP5L
1.054e-02	-4.55	TRPM_tetra	interpro domains	IPR032415	4	1	18521	49	TRPM3
1.054e-02	-4.55	LLGL2	interpro domains	IPR013577	4	1	18521	49	STXBP5L
1.054e-02	-4.55	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	49	NFIA
1.054e-02	-4.55	VDCC_a2/dsu	interpro domains	IPR013680	4	1	18521	49	CACNA2D1
1.054e-02	-4.55	Transcription_factor_COE	interpro domains	IPR003523	4	1	18521	49	EBF1
1.054e-02	-4.55	ApoA_E	interpro domains	IPR000074	4	1	18521	49	APOE
1.054e-02	-4.55	VWA_N	interpro domains	IPR013608	4	1	18521	49	CACNA2D1
1.054e-02	-4.55	COE_DBD_sf	interpro domains	IPR038173	4	1	18521	49	EBF1
1.054e-02	-4.55	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	49	TRPM3
1.054e-02	-4.55	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	49	NFIA
1.054e-02	-4.55	COE_HLH	interpro domains	IPR032201	4	1	18521	49	EBF1
1.054e-02	-4.55	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	49	NFIA
1.054e-02	-4.55	COE_DBD	interpro domains	IPR032200	4	1	18521	49	EBF1
1.054e-02	-4.55	Transcription_factor_COE_CS	interpro domains	IPR018350	4	1	18521	49	EBF1
1.054e-02	-4.55	CTF/NFI	interpro domains	IPR000647	4	1	18521	49	NFIA
1.054e-02	-4.55	COE_IPT	interpro domains	IPR038006	4	1	18521	49	EBF1
1.062e-02	-4.55	membrane organization	biological process	GO:0061024	761	6	18204	45	CNTNAP2,NRXN1,APOE,RIMS1,RELN,ANK2
1.071e-02	-4.54	Heparan sulfate/heparin (HS-GAG) metabolism	REACTOME pathways	R-HSA-1638091	54	2	10285	30	GPC6,GLCE
1.074e-02	-4.53	positive regulation of cell communication	biological process	GO:0010647	1792	10	18204	45	SLC1A3,NRXN1,RIMS1,GRIK2,RIMS2,RELN,NRG1,APOE,GLCE,SYT1
1.075e-02	-4.53	Ephrin A reverse signaling	Pathway Interaction DB	ephrinarevpathway	3	1	2226	8	EPHA5
1.082e-02	-4.53	positive regulation of signaling	biological process	GO:0023056	1794	10	18204	45	SYT1,GLCE,APOE,NRG1,RIMS1,GRIK2,RIMS2,RELN,SLC1A3,NRXN1
1.084e-02	-4.52	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	47	16828	48	MYT1L,TLL1,GRIA4,FSTL5,EBF1,GRIK2,ANK2,CNTN5,CNTNAP2,LINGO2,CACNA2D1,EPHA5,PTPRG,GLCE,GPC6,CNTN4,DTNA,NRXN3,LSAMP,UNC5C,TRPM3,NRG3,RIMS2,KCNJ3,ZNF385D,STXBP5L,LRRTM4,RUNX1T1,NRG1,RALYL,SLC35F3,CHN2,SLC1A3,NRXN1,NPAS3,ST18,NFIA,PCDH9,APOE,ZNF385B,RIMS1,RELN,SYT1,GRID2,KIF21A,CADPS2,CDH18
1.087e-02	-4.52	ETOFAMILY	prints domains	PR01875	3	1	5227	19	RUNX1T1
1.101e-02	-4.51	NLGN2 (neuroligin 2)	protein interactions	57555	63	2	19454	49	NRXN3,NRXN1
1.105e-02	-4.51	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	3	18094	45	GRIA4,GRIK2,SLC1A3
1.106e-02	-4.50	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	46	16828	48	MYT1L,FSTL5,EBF1,TLL1,GRIA4,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,EPHA5,CACNA2D1,GLCE,PTPRG,CNTN4,GPC6,LSAMP,UNC5C,DTNA,NRXN3,RIMS2,NRG3,TRPM3,LRRTM4,STXBP5L,ZNF385D,KCNJ3,SLC35F3,NRG1,RUNX1T1,RALYL,NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,NFIA,ST18,RELN,RIMS1,ZNF385B,KIF21A,CDH18,CADPS2,GRID2,SYT1
1.106e-02	-4.50	bladder	COSMIC cancer mutations	bladder	14112	46	16828	48	NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,ST18,NFIA,RELN,RIMS1,ZNF385B,CADPS2,CDH18,KIF21A,GRID2,SYT1,RIMS2,NRG3,TRPM3,LRRTM4,STXBP5L,ZNF385D,KCNJ3,SLC35F3,RALYL,RUNX1T1,NRG1,EPHA5,CACNA2D1,GLCE,PTPRG,CNTN4,GPC6,UNC5C,LSAMP,NRXN3,DTNA,MYT1L,EBF1,FSTL5,GRIA4,TLL1,CNTN5,ANK2,GRIK2,LINGO2,CNTNAP2
1.120e-02	-4.49	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	49	NPAS3
1.121e-02	-4.49	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	3	18094	45	GRIK2,SLC1A3,GRIA4
1.126e-02	-4.49	forebrain cell migration	biological process	GO:0021885	65	2	18204	45	NRG3,RELN
1.151e-02	-4.46	pallium development	biological process	GO:0021543	190	3	18204	45	CNTNAP2,RELN,EPHA5
1.156e-02	-4.46	liver-carcinoma	COSMIC cancer mutations	liver-carcinoma	15337	48	16828	48	ST18,NFIA,PCDH9,NRXN1,NPAS3,CHN2,SLC1A3,GRID2,CDH18,CADPS2,KIF21A,SYT1,RELN,ZNF385B,APOE,RIMS1,RIMS2,TRPM3,NRG3,RALYL,RUNX1T1,NRG1,SLC35F3,STXBP5L,CST3,LRRTM4,KCNJ3,ZNF385D,PTPRG,GLCE,EPHA5,CACNA2D1,NRXN3,DTNA,UNC5C,LSAMP,CNTN4,GPC6,EBF1,FSTL5,GRIA4,TLL1,MYT1L,LINGO2,CNTNAP2,CNTN5,ANK2,GRIK2
1.159e-02	-4.46	ERBB signaling pathway	biological process	GO:0038127	66	2	18204	45	NRG3,NRG1
1.162e-02	-4.46	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	1	10285	30	SLC1A3
1.162e-02	-4.46	Activation of AMPA receptors	REACTOME pathways	R-HSA-399710	4	1	10285	30	GRIA4
1.162e-02	-4.46	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	1	10285	30	SLC1A3
1.178e-02	-4.44	C2 domain	gene3d domains	2.60.40.150	156	3	14470	44	RIMS1,RIMS2,SYT1
1.183e-02	-4.44	C2	smart domains	SM00239	122	3	9717	38	SYT1,RIMS1,RIMS2
1.193e-02	-4.43	excitatory postsynaptic potential	biological process	GO:0060079	67	2	18204	45	GRIK2,GRID2
1.205e-02	-4.42	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	48	16828	48	RUNX1T1,NRG1,RALYL,SLC35F3,KCNJ3,ZNF385D,STXBP5L,LRRTM4,CST3,TRPM3,NRG3,RIMS2,SYT1,GRID2,KIF21A,CDH18,CADPS2,APOE,ZNF385B,RIMS1,RELN,ST18,NFIA,PCDH9,CHN2,SLC1A3,NRXN1,NPAS3,CNTNAP2,LINGO2,GRIK2,ANK2,CNTN5,TLL1,GRIA4,EBF1,FSTL5,MYT1L,DTNA,NRXN3,LSAMP,UNC5C,GPC6,CNTN4,PTPRG,GLCE,CACNA2D1,EPHA5
1.207e-02	-4.42	cell adhesion mediator activity	molecular function	GO:0098631	67	2	18094	45	CNTN5,CNTN4
1.211e-02	-4.41	-	gene3d domains	6.10.250.230	4	1	14470	44	RUNX1T1
1.211e-02	-4.41	Transcription factor COE1, DNA-binding domain	gene3d domains	2.60.40.3180	4	1	14470	44	EBF1
1.211e-02	-4.41	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	44	TRPM3
1.211e-02	-4.41	-	gene3d domains	1.10.287.4280	4	1	14470	44	EBF1
1.223e-02	-4.40	plasma membrane signaling receptor complex	cellular component	GO:0098802	191	3	19108	48	GRIK2,GRIA4,GRID2
1.230e-02	-4.40	regulation of homophilic cell adhesion	biological process	GO:1903385	5	1	18204	45	PTPRG
1.230e-02	-4.40	bundle of His cell action potential	biological process	GO:0086043	5	1	18204	45	CACNA2D1
1.230e-02	-4.40	atrial cardiac muscle cell membrane repolarization	biological process	GO:0099624	5	1	18204	45	KCNJ3
1.230e-02	-4.40	D-aspartate import across plasma membrane	biological process	GO:0070779	5	1	18204	45	SLC1A3
1.230e-02	-4.40	membrane depolarization during SA node cell action potential	biological process	GO:0086046	5	1	18204	45	ANK2
1.230e-02	-4.40	detection of temperature stimulus involved in thermoception	biological process	GO:0050960	5	1	18204	45	GRIK2
1.230e-02	-4.40	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	45	NRXN1
1.230e-02	-4.40	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	45	APOE
1.230e-02	-4.40	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	45	APOE
1.230e-02	-4.40	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	45	APOE
1.230e-02	-4.40	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	45	APOE
1.230e-02	-4.40	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	45	APOE
1.230e-02	-4.40	ERBB2-ERBB4 signaling pathway	biological process	GO:0038135	5	1	18204	45	NRG1
1.230e-02	-4.40	bundle of His cell to Purkinje myocyte signaling	biological process	GO:0086028	5	1	18204	45	CACNA2D1
1.230e-02	-4.40	membrane repolarization during atrial cardiac muscle cell action potential	biological process	GO:0098914	5	1	18204	45	KCNJ3
1.230e-02	-4.40	D-aspartate transmembrane transport	biological process	GO:0070777	5	1	18204	45	SLC1A3
1.237e-02	-4.39	glutamate:sodium symporter activity	molecular function	GO:0015501	5	1	18094	45	SLC1A3
1.237e-02	-4.39	ErbB-3 class receptor binding	molecular function	GO:0043125	5	1	18094	45	NRG1
1.237e-02	-4.39	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	1	18094	45	SLC1A3
1.237e-02	-4.39	netrin receptor activity	molecular function	GO:0005042	5	1	18094	45	UNC5C
1.237e-02	-4.39	metal ion sensor activity	molecular function	GO:0140784	5	1	18094	45	SYT1
1.237e-02	-4.39	kainate selective glutamate receptor activity	molecular function	GO:0015277	5	1	18094	45	GRIK2
1.237e-02	-4.39	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	molecular function	GO:0086007	5	1	18094	45	CACNA2D1
1.250e-02	-4.38	kainate selective glutamate receptor complex	cellular component	GO:0032983	5	1	19108	48	GRIK2
1.250e-02	-4.38	clathrin-sculpted monoamine transport vesicle	cellular component	GO:0070081	5	1	19108	48	SYT1
1.250e-02	-4.38	clathrin-sculpted monoamine transport vesicle membrane	cellular component	GO:0070083	5	1	19108	48	SYT1
1.253e-02	-4.38	DLX4 (distal-less homeobox 4)	protein interactions	1748	5	1	19454	49	GPC6
1.253e-02	-4.38	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	49	NRXN1
1.253e-02	-4.38	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	49	TRPM3
1.253e-02	-4.38	Calu (calumenin)	protein interactions	12321	5	1	19454	49	CACNA2D1
1.253e-02	-4.38	Ncam1 (neural cell adhesion molecule 1)	protein interactions	24586	5	1	19454	49	STXBP5L
1.305e-02	-4.34	human chr13q21.32	chromosome location	human chr13q21.32	7	1	26134	49	PCDH9
1.307e-02	-4.34	CTF_NFI_1	prosite domains	PS00349	4	1	12186	40	NFIA
1.307e-02	-4.34	COE	prosite domains	PS01345	4	1	12186	40	EBF1
1.307e-02	-4.34	CTF_NFI_2	prosite domains	PS51080	4	1	12186	40	NFIA
1.312e-02	-4.33	scaffold protein binding	molecular function	GO:0097110	70	2	18094	45	GRIK2,GRID2
1.314e-02	-4.33	Protocadherin	pfam domains	PF08374	5	1	17795	47	PCDH9
1.314e-02	-4.33	EGF_Tenascin	pfam domains	PF18720	5	1	17795	47	RELN
1.314e-02	-4.33	TAFH	pfam domains	PF07531	5	1	17795	47	RUNX1T1
1.314e-02	-4.33	UPA	pfam domains	PF17217	5	1	17795	47	UNC5C
1.315e-02	-4.33	EGF	pfam domains	PF00008	66	2	17795	47	NRXN1,NRG1
1.316e-02	-4.33	TAFH_NHR1	interpro domains	IPR003894	5	1	18521	49	RUNX1T1
1.316e-02	-4.33	Sialidase_sf	interpro domains	IPR036278	5	1	18521	49	RELN
1.316e-02	-4.33	UPA	interpro domains	IPR033772	5	1	18521	49	UNC5C
1.316e-02	-4.33	EGF_Tenascin	interpro domains	IPR041161	5	1	18521	49	RELN
1.316e-02	-4.33	Protocadherin	interpro domains	IPR013585	5	1	18521	49	PCDH9
1.316e-02	-4.33	UNC5	interpro domains	IPR037936	5	1	18521	49	UNC5C
1.316e-02	-4.33	TAFH/NHR1_dom_sf	interpro domains	IPR037249	5	1	18521	49	RUNX1T1
1.316e-02	-4.33	neuron to neuron synapse	cellular component	GO:0098984	365	4	19108	48	SYT1,GRIK2,GRIA4,GRID2
1.336e-02	-4.32	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	4	16828	48	CACNA2D1,TLL1,KCNJ3,GRID2
1.346e-02	-4.31	GPC4 (glypican 4)	protein interactions	2239	70	2	19454	49	LRRTM4,GPC6
1.357e-02	-4.30	intracellular calcium ion homeostasis	biological process	GO:0006874	202	3	18204	45	GRIK2,ANK2,APOE
1.359e-02	-4.30	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	46	16828	48	LRRTM4,STXBP5L,ZNF385D,KCNJ3,SLC35F3,NRG1,RUNX1T1,RALYL,RIMS2,NRG3,TRPM3,RELN,RIMS1,ZNF385B,KIF21A,CADPS2,CDH18,GRID2,SYT1,NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,ST18,NFIA,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,MYT1L,EBF1,FSTL5,TLL1,GRIA4,CNTN4,GPC6,LSAMP,UNC5C,DTNA,NRXN3,EPHA5,CACNA2D1,GLCE,PTPRG
1.393e-02	-4.27	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	19	16828	48	PCDH9,TLL1,ST18,PTPRG,FSTL5,NRG3,RIMS2,CNTNAP2,NRG1,NRXN3,KIF21A,CDH18,GPC6,ZNF385D,ANK2,GRIK2,RELN,STXBP5L,CNTN4
1.405e-02	-4.27	neuron fate commitment	biological process	GO:0048663	73	2	18204	45	MYT1L,NFIA
1.405e-02	-4.27	chemical synaptic transmission, postsynaptic	biological process	GO:0099565	73	2	18204	45	GRID2,GRIK2
1.420e-02	-4.25	RAB3A (RAB3A, member RAS oncogene family)	protein interactions	5864	72	2	19454	49	RIMS1,RIMS2
1.439e-02	-4.24	endocytic vesicle membrane	cellular component	GO:0030666	203	3	19108	48	GRIA4,APOE,SYT1
1.446e-02	-4.24	LETHAL2GIANT	prints domains	PR00962	4	1	5227	19	STXBP5L
1.450e-02	-4.23	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	4	16828	48	GRID2,CACNA2D1,TLL1,KCNJ3
1.450e-02	-4.23	Reelin signalling pathway	REACTOME pathways	R-HSA-8866376	5	1	10285	30	RELN
1.450e-02	-4.23	GRB7 events in ERBB2 signaling	REACTOME pathways	R-HSA-1306955	5	1	10285	30	NRG1
1.458e-02	-4.23	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	47	16828	48	RALYL,NRG1,RUNX1T1,SLC35F3,KCNJ3,ZNF385D,STXBP5L,CST3,LRRTM4,TRPM3,NRG3,RIMS2,SYT1,GRID2,CADPS2,CDH18,KIF21A,ZNF385B,APOE,RIMS1,RELN,NFIA,ST18,PCDH9,CHN2,SLC1A3,NRXN1,NPAS3,CNTNAP2,LINGO2,ANK2,GRIK2,CNTN5,GRIA4,TLL1,EBF1,FSTL5,MYT1L,NRXN3,UNC5C,LSAMP,GPC6,CNTN4,PTPRG,GLCE,CACNA2D1,EPHA5
1.458e-02	-4.23	ovary	COSMIC cancer mutations	ovary	14770	47	16828	48	RIMS2,TRPM3,NRG3,STXBP5L,LRRTM4,CST3,KCNJ3,ZNF385D,NRG1,RUNX1T1,RALYL,SLC35F3,NRXN1,NPAS3,CHN2,SLC1A3,ST18,PCDH9,RELN,APOE,ZNF385B,RIMS1,GRID2,KIF21A,CADPS2,CDH18,SYT1,MYT1L,FSTL5,EBF1,TLL1,GRIA4,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,EPHA5,CACNA2D1,PTPRG,GLCE,CNTN4,GPC6,DTNA,NRXN3,LSAMP,UNC5C
1.467e-02	-4.22	regulation of heart contraction	biological process	GO:0008016	208	3	18204	45	CACNA2D1,ANK2,KCNJ3
1.474e-02	-4.22	chemorepulsion of axon	biological process	GO:0061643	6	1	18204	45	UNC5C
1.474e-02	-4.22	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	45	APOE
1.474e-02	-4.22	activation of transmembrane receptor protein tyrosine kinase activity	biological process	GO:0007171	6	1	18204	45	NRG1
1.474e-02	-4.22	T-tubule organization	biological process	GO:0033292	6	1	18204	45	ANK2
1.474e-02	-4.22	D-amino acid transport	biological process	GO:0042940	6	1	18204	45	SLC1A3
1.474e-02	-4.22	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	45	SLC1A3
1.474e-02	-4.22	endocardial cell differentiation	biological process	GO:0060956	6	1	18204	45	NRG1
1.474e-02	-4.22	acrosomal vesicle exocytosis	biological process	GO:0060478	6	1	18204	45	RIMS1
1.474e-02	-4.22	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	45	APOE
1.474e-02	-4.22	L-aspartate import across plasma membrane	biological process	GO:0140009	6	1	18204	45	SLC1A3
1.474e-02	-4.22	mammary gland formation	biological process	GO:0060592	6	1	18204	45	NRG3
1.474e-02	-4.22	positive regulation of dopamine secretion	biological process	GO:0033603	6	1	18204	45	SYT1
1.474e-02	-4.22	paranodal junction assembly	biological process	GO:0030913	6	1	18204	45	ANK2
1.474e-02	-4.22	cerebral cortex tangential migration	biological process	GO:0021800	6	1	18204	45	RELN
1.474e-02	-4.22	cardiac endothelial cell differentiation	biological process	GO:0003348	6	1	18204	45	NRG1
1.474e-02	-4.22	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	45	CST3
1.479e-02	-4.21	regulation of behavior	biological process	GO:0050795	75	2	18204	45	APOE,RELN
1.479e-02	-4.21	regulation of calcium ion transmembrane transporter activity	biological process	GO:1901019	75	2	18204	45	CACNA2D1,ANK2
1.483e-02	-4.21	ankyrin repeat binding	molecular function	GO:0071532	6	1	18094	45	KIF21A
1.483e-02	-4.21	GPI-linked ephrin receptor activity	molecular function	GO:0005004	6	1	18094	45	EPHA5
1.483e-02	-4.21	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	45	APOE
1.488e-02	-4.21	cell-cell contact zone	cellular component	GO:0044291	74	2	19108	48	PCDH9,ANK2
1.490e-02	-4.21	human chr4q32.2	chromosome location	human chr4q32.2	8	1	26134	49	FSTL5
1.498e-02	-4.20	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	48	APOE
1.502e-02	-4.20	GRID2IP (Grid2 interacting protein)	protein interactions	392862	6	1	19454	49	GRID2
1.502e-02	-4.20	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	49	NRXN1
1.502e-02	-4.20	Tubb4b (tubulin, beta 4B class IVb)	protein interactions	296554	6	1	19454	49	STXBP5L
1.502e-02	-4.20	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	49	DTNA
1.502e-02	-4.20	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	49	APOE
1.502e-02	-4.20	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	49	APOE
1.502e-02	-4.20	CNTN4 (contactin 4)	protein interactions	152330	6	1	19454	49	CNTN4
1.502e-02	-4.20	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	49	DTNA
1.511e-02	-4.19	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	44	APOE
1.511e-02	-4.19	TAFH/NHR1 domain	gene3d domains	1.20.120.1110	5	1	14470	44	RUNX1T1
1.516e-02	-4.19	positive regulation of exocytosis	biological process	GO:0045921	76	2	18204	45	CADPS2,SYT1
1.526e-02	-4.18	clathrin-coated endocytic vesicle membrane	cellular component	GO:0030669	75	2	19108	48	APOE,SYT1
1.527e-02	-4.18	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	30	NRG1,NRG3
1.528e-02	-4.18	neoplasm	COSMIC cancer mutations	neoplasm	14787	47	16828	48	RALYL,NRG1,RUNX1T1,SLC35F3,STXBP5L,CST3,KCNJ3,ZNF385D,RIMS2,TRPM3,NRG3,GRID2,CADPS2,CDH18,KIF21A,SYT1,RELN,ZNF385B,APOE,RIMS1,NFIA,ST18,PCDH9,NRXN1,NPAS3,CHN2,SLC1A3,LINGO2,CNTNAP2,CNTN5,ANK2,GRIK2,FSTL5,EBF1,GRIA4,TLL1,MYT1L,NRXN3,DTNA,UNC5C,LSAMP,CNTN4,GPC6,PTPRG,GLCE,EPHA5,CACNA2D1
1.543e-02	-4.17	positive regulation of monoatomic ion transport	biological process	GO:0043270	212	3	18204	45	ANK2,CACNA2D1,RELN
1.571e-02	-4.15	Synaptic vesicle cycle	KEGG pathways	hsa04721	63	2	7161	22	SYT1,RIMS1
1.571e-02	-4.15	Synaptic vesicle cycle	KEGG pathways	ko04721	63	2	7161	22	RIMS1,SYT1
1.575e-02	-4.15	Glypican	pfam domains	PF01153	6	1	17795	47	GPC6
1.575e-02	-4.15	EF-hand_2	pfam domains	PF09068	6	1	17795	47	DTNA
1.575e-02	-4.15	EF-hand_3	pfam domains	PF09069	6	1	17795	47	DTNA
1.575e-02	-4.15	Astacin	pfam domains	PF01400	6	1	17795	47	TLL1
1.577e-02	-4.15	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	49	DTNA
1.577e-02	-4.15	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	49	DTNA
1.577e-02	-4.15	Glypican_CS	interpro domains	IPR019803	6	1	18521	49	GPC6
1.577e-02	-4.15	hnRNP_C	interpro domains	IPR017347	6	1	18521	49	RALYL
1.577e-02	-4.15	Glypican	interpro domains	IPR001863	6	1	18521	49	GPC6
1.577e-02	-4.15	Peptidase_M12A	interpro domains	IPR001506	6	1	18521	49	TLL1
1.582e-02	-4.15	regulation of monoatomic ion transmembrane transporter activity	biological process	GO:0032412	214	3	18204	45	RELN,CACNA2D1,ANK2
1.582e-02	-4.15	positive regulation of transmembrane transport	biological process	GO:0034764	214	3	18204	45	CACNA2D1,RELN,ANK2
1.595e-02	-4.14	localization	biological process	GO:0051179	4474	18	18204	45	KCNJ3,CACNA2D1,ANK2,GRID2,STXBP5L,SYT1,NRXN1,RIMS2,RIMS1,GRIA4,APOE,TRPM3,SLC35F3,SLC1A3,CNTNAP2,RELN,CADPS2,GRIK2
1.604e-02	-4.13	enzyme activator activity	molecular function	GO:0008047	599	5	18094	45	APOE,NRG3,STXBP5L,NRG1,CHN2
1.608e-02	-4.13	regulation of growth	biological process	GO:0040008	603	5	18204	45	SYT1,RIMS1,NRG3,RIMS2,APOE
1.613e-02	-4.13	FCHO2 (FCH and mu domain containing endocytic adaptor 2)	protein interactions	115548	77	2	19454	49	EPHA5,PTPRG
1.617e-02	-4.12	Signaling by PTK6	REACTOME pathways	R-HSA-8848021	67	2	10285	30	NRG3,NRG1
1.631e-02	-4.12	TAFH	prosite domains	PS51119	5	1	12186	40	RUNX1T1
1.641e-02	-4.11	Galactose-bd-like_sf	interpro domains	IPR008979	74	2	18521	49	CNTNAP2,EPHA5
1.652e-02	-4.10	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	49	APOE,RELN
1.673e-02	-4.09	zinc ion binding	molecular function	GO:0008270	836	6	18094	45	TLL1,ST18,ZNF385B,ZNF385D,MYT1L,DTNA
1.675e-02	-4.09	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	49	UNC5C
1.684e-02	-4.08	presynaptic active zone	cellular component	GO:0048786	79	2	19108	48	RIMS2,RIMS1
1.700e-02	-4.07	positive regulation of transport	biological process	GO:0051050	844	6	18204	45	CACNA2D1,RELN,ANK2,CADPS2,SYT1,APOE
1.702e-02	-4.07	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	45	SLC1A3,NRXN1,CNTNAP2
1.715e-02	-4.07	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	29	16828	48	NRG3,MYT1L,TRPM3,TLL1,GRIA4,FSTL5,ANK2,GRIK2,CST3,CNTN5,NRG1,RUNX1T1,LINGO2,SLC1A3,CACNA2D1,NPAS3,EPHA5,NRXN1,GLCE,ST18,PTPRG,RIMS1,RELN,UNC5C,DTNA,NRXN3,KIF21A,CDH18,GRID2
1.718e-02	-4.06	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	45	APOE
1.718e-02	-4.06	dense core granule exocytosis	biological process	GO:1990504	7	1	18204	45	CADPS2
1.718e-02	-4.06	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	45	APOE
1.718e-02	-4.06	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	biological process	GO:2001269	7	1	18204	45	ST18
1.718e-02	-4.06	positive regulation of voltage-gated calcium channel activity	biological process	GO:1901387	7	1	18204	45	CACNA2D1
1.718e-02	-4.06	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	45	NRG3
1.718e-02	-4.06	cerebellar granular layer formation	biological process	GO:0021684	7	1	18204	45	GRID2
1.718e-02	-4.06	dorsal root ganglion development	biological process	GO:1990791	7	1	18204	45	UNC5C
1.718e-02	-4.06	SA node cell to atrial cardiac muscle cell signaling	biological process	GO:0086018	7	1	18204	45	ANK2
1.718e-02	-4.06	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	45	APOE
1.718e-02	-4.06	positive regulation of long-term synaptic depression	biological process	GO:1900454	7	1	18204	45	GRID2
1.718e-02	-4.06	positive regulation of gap junction assembly	biological process	GO:1903598	7	1	18204	45	CNTNAP2
1.718e-02	-4.06	anterior/posterior axon guidance	biological process	GO:0033564	7	1	18204	45	UNC5C
1.718e-02	-4.06	SA node cell action potential	biological process	GO:0086015	7	1	18204	45	ANK2
1.718e-02	-4.06	glial cell fate specification	biological process	GO:0021780	7	1	18204	45	NFIA
1.718e-02	-4.06	cerebellar granule cell differentiation	biological process	GO:0021707	7	1	18204	45	GRID2
1.733e-02	-4.06	STX2 (syntaxin 2)	protein interactions	2054	80	2	19454	49	STXBP5L,SYT1
1.743e-02	-4.05	regulation of transmembrane transporter activity	biological process	GO:0022898	222	3	18204	45	ANK2,RELN,CACNA2D1
1.750e-02	-4.05	SV2B (synaptic vesicle glycoprotein 2B)	protein interactions	9899	7	1	19454	49	SYT1
1.750e-02	-4.05	CHL1 (cell adhesion molecule L1 like)	protein interactions	10752	7	1	19454	49	ANK2
1.750e-02	-4.05	CDH18 (cadherin 18)	protein interactions	1016	7	1	19454	49	CDH18
1.750e-02	-4.05	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	49	NPAS3
1.752e-02	-4.04	central_nervous_system-brain-glioma	COSMIC cancer mutations	central_nervous_system-brain-glioma	15470	48	16828	48	TLL1,GRIA4,EBF1,FSTL5,MYT1L,CNTNAP2,LINGO2,GRIK2,ANK2,CNTN5,GLCE,PTPRG,CACNA2D1,EPHA5,LSAMP,UNC5C,DTNA,NRXN3,GPC6,CNTN4,NRG3,TRPM3,RIMS2,SLC35F3,RUNX1T1,NRG1,RALYL,ZNF385D,KCNJ3,LRRTM4,CST3,STXBP5L,PCDH9,NFIA,ST18,SLC1A3,CHN2,NPAS3,NRXN1,SYT1,KIF21A,CDH18,CADPS2,GRID2,RIMS1,APOE,ZNF385B,RELN
1.771e-02	-4.03	receptor tyrosine kinase binding	molecular function	GO:0030971	82	2	18094	45	NRG1,NRG3
1.774e-02	-4.03	GRIP1 (glutamate receptor interacting protein 1)	protein interactions	23426	81	2	19454	49	GRIK2,GRIA4
1.783e-02	-4.03	other	COSMIC cancer mutations	other	14843	47	16828	48	MYT1L,GRIA4,TLL1,FSTL5,EBF1,ANK2,GRIK2,CNTN5,CNTNAP2,LINGO2,CACNA2D1,EPHA5,GLCE,PTPRG,GPC6,CNTN4,UNC5C,LSAMP,NRXN3,DTNA,NRG3,TRPM3,RIMS2,ZNF385D,KCNJ3,CST3,STXBP5L,SLC35F3,RALYL,NRG1,RUNX1T1,SLC1A3,CHN2,NPAS3,NRXN1,PCDH9,NFIA,ST18,RIMS1,ZNF385B,APOE,RELN,SYT1,CDH18,CADPS2,KIF21A,GRID2
1.791e-02	-4.02	positive regulation of calcium ion transmembrane transport	biological process	GO:1904427	83	2	18204	45	CACNA2D1,ANK2
1.835e-02	-4.00	EamA	pfam domains	PF00892	7	1	17795	47	SLC35F3
1.835e-02	-4.00	SDF	pfam domains	PF00375	7	1	17795	47	SLC1A3
1.835e-02	-4.00	MUN	pfam domains	PF06292	7	1	17795	47	CADPS2
1.838e-02	-4.00	EamA_dom	interpro domains	IPR000620	7	1	18521	49	SLC35F3
1.838e-02	-4.00	Munc13_1	interpro domains	IPR014770	7	1	18521	49	CADPS2
1.838e-02	-4.00	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	1	18521	49	SLC1A3
1.838e-02	-4.00	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	1	18521	49	SLC1A3
1.838e-02	-4.00	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	1	18521	49	SLC1A3
1.838e-02	-4.00	MUN_dom	interpro domains	IPR010439	7	1	18521	49	CADPS2
1.847e-02	-3.99	FBXO2 (F-box protein 2)	protein interactions	26232	403	4	19454	49	EPHA5,CACNA2D1,PTPRG,PCDH9
1.851e-02	-3.99	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	34	16828	48	SLC35F3,CNTNAP2,RALYL,RUNX1T1,CNTN5,LRRTM4,STXBP5L,ANK2,KCNJ3,FSTL5,EBF1,GRIA4,TLL1,RIMS2,TRPM3,CADPS2,CDH18,KIF21A,GRID2,UNC5C,SYT1,LSAMP,NRXN3,RELN,CNTN4,GPC6,APOE,PCDH9,ST18,PTPRG,NFIA,EPHA5,CACNA2D1,CHN2
1.858e-02	-3.99	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	49	GLCE,NFIA
1.860e-02	-3.98	human chr8q21.2	chromosome location	human chr8q21.2	10	1	26134	49	RALYL
1.860e-02	-3.98	human chr11q22.1	chromosome location	human chr11q22.1	10	1	26134	49	CNTN5
1.861e-02	-3.98	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	45	NRG1,PTPRG,NFIA,NRG3,EPHA5
1.885e-02	-3.97	transmembrane transporter activity	molecular function	GO:0022857	1110	7	18094	45	GRID2,GRIK2,TRPM3,CACNA2D1,SLC1A3,GRIA4,KCNJ3
1.885e-02	-3.97	heparan sulfate biosynthesis (late stages)	BIOCYC pathways	META_PWY-6558	17	1	902	1	GLCE
1.900e-02	-3.96	TMEM185A (transmembrane protein 185A)	protein interactions	84548	84	2	19454	49	PTPRG,CACNA2D1
1.907e-02	-3.96	metal ion transport	biological process	GO:0030001	630	5	18204	45	TRPM3,KCNJ3,SLC1A3,ANK2,CACNA2D1
1.915e-02	-3.96	protein localization to cell junction	biological process	GO:1902414	86	2	18204	45	NRXN1,RELN
1.920e-02	-3.95	EGF_1	prosite domains	PS00022	174	3	12186	40	NRG3,RELN,NRG1
1.926e-02	-3.95	BCL6 (BCL6 transcription repressor)	protein interactions	604	226	3	19454	49	EBF1,RUNX1T1,PCDH9
1.935e-02	-3.95	calcium ion homeostasis	biological process	GO:0055074	231	3	18204	45	GRIK2,ANK2,APOE
1.940e-02	-3.94	TAFH	smart domains	SM00549	5	1	9717	38	RUNX1T1
1.940e-02	-3.94	DUF1041	smart domains	SM01145	5	1	9717	38	CADPS2
1.946e-02	-3.94	blood circulation	biological process	GO:0008015	418	4	18204	45	APOE,KCNJ3,CACNA2D1,ANK2
1.951e-02	-3.94	Lipoprotein metabolism	REACTOME pathways	R-HSA-174824	74	2	10285	30	APOE,RELN
1.952e-02	-3.94	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	5	18094	45	KCNJ3,SLC1A3,CACNA2D1,TRPM3,GRIK2
1.954e-02	-3.94	GLYPICAN	prosite domains	PS01207	6	1	12186	40	GPC6
1.954e-02	-3.94	ASTACIN	prosite domains	PS51864	6	1	12186	40	TLL1
1.961e-02	-3.93	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	45	APOE
1.961e-02	-3.93	positive regulation of vesicle fusion	biological process	GO:0031340	8	1	18204	45	SYT1
1.961e-02	-3.93	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	45	APOE
1.961e-02	-3.93	thermoception	biological process	GO:0050955	8	1	18204	45	GRIK2
1.961e-02	-3.93	reelin-mediated signaling pathway	biological process	GO:0038026	8	1	18204	45	RELN
1.961e-02	-3.93	thiamine transport	biological process	GO:0015888	8	1	18204	45	SLC35F3
1.961e-02	-3.93	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	45	APOE
1.961e-02	-3.93	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	45	SLC1A3
1.961e-02	-3.93	negative regulation of synaptic transmission, glutamatergic	biological process	GO:0051967	8	1	18204	45	GRIK2
1.961e-02	-3.93	protein import	biological process	GO:0017038	8	1	18204	45	APOE
1.961e-02	-3.93	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	45	APOE
1.973e-02	-3.93	glutamate binding	molecular function	GO:0016595	8	1	18094	45	SLC1A3
1.973e-02	-3.93	phosphorylation-dependent protein binding	molecular function	GO:0140031	8	1	18094	45	ANK2
1.992e-02	-3.92	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	cellular component	GO:0061202	8	1	19108	48	SYT1
1.992e-02	-3.92	clathrin-sculpted gamma-aminobutyric acid transport vesicle	cellular component	GO:0061200	8	1	19108	48	SYT1
1.992e-02	-3.92	paranodal junction	cellular component	GO:0033010	8	1	19108	48	CNTNAP2
1.998e-02	-3.91	PCDHA6 (protocadherin alpha 6)	protein interactions	56142	8	1	19454	49	RELN
1.998e-02	-3.91	PRSS33 (serine protease 33)	protein interactions	260429	8	1	19454	49	CACNA2D1
1.998e-02	-3.91	DEFB104A (defensin beta 104A)	protein interactions	140596	8	1	19454	49	PTPRG
1.998e-02	-3.91	CDH6 (cadherin 6)	protein interactions	1004	8	1	19454	49	CDH18
1.998e-02	-3.91	GRIK4 (glutamate ionotropic receptor kainate type subunit 4)	protein interactions	2900	8	1	19454	49	GRIK2
1.998e-02	-3.91	PKD1L1-AS1 (PKD1L1 antisense RNA 1)	protein interactions	80099	8	1	19454	49	CACNA2D1
1.998e-02	-3.91	KCNJ9 (potassium inwardly rectifying channel subfamily J member 9)	protein interactions	3765	8	1	19454	49	KCNJ3
1.998e-02	-3.91	TAFA1 (TAFA chemokine like family member 1)	protein interactions	407738	8	1	19454	49	NRXN3
2.002e-02	-3.91	Axon guidance	REACTOME pathways	R-HSA-422475	549	5	10285	30	NRG3,UNC5C,NRG1,ANK2,EPHA5
2.007e-02	-3.91	establishment of localization	biological process	GO:0051234	3887	16	18204	45	NRXN1,RIMS2,RIMS1,KCNJ3,CACNA2D1,ANK2,STXBP5L,GRID2,SYT1,SLC35F3,SLC1A3,CADPS2,GRIK2,GRIA4,APOE,TRPM3
2.015e-02	-3.90	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	48	GRIA4,CDH18,KIF21A,FSTL5,STXBP5L
2.016e-02	-3.90	ConA-like_dom_sf	interpro domains	IPR013320	219	3	18521	49	NRXN1,CNTNAP2,NRXN3
2.042e-02	-3.89	cell fate specification	biological process	GO:0001708	89	2	18204	45	MYT1L,NFIA
2.042e-02	-3.89	multicellular organismal response to stress	biological process	GO:0033555	89	2	18204	45	GRIK2,RELN
2.058e-02	-3.88	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	5	16828	48	CNTNAP2,CACNA2D1,EPHA5,CNTN5,FSTL5
2.068e-02	-3.88	pelvis	COSMIC cancer mutations	pelvis	984	7	16828	48	CHN2,RIMS1,ANK2,CNTN5,PTPRG,LSAMP,GRID2
2.073e-02	-3.88	CCNL2 (cyclin L2)	protein interactions	81669	88	2	19454	49	LRRTM4,PTPRG
2.073e-02	-3.88	NLGN3 (neuroligin 3)	protein interactions	54413	88	2	19454	49	NRXN1,NRXN3
2.073e-02	-3.88	BTN2A2 (butyrophilin subfamily 2 member A2)	protein interactions	10385	88	2	19454	49	SLC1A3,SYT1
2.087e-02	-3.87	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	5	16828	48	CACNA2D1,CNTNAP2,EPHA5,CNTN5,FSTL5
2.094e-02	-3.87	LSDAT_euk	pfam domains	PF18139	8	1	17795	47	TRPM3
2.097e-02	-3.86	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	49	TRPM3
2.102e-02	-3.86	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	45	NRG3,EPHA5,PTPRG,NRG1
2.102e-02	-3.86	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	4	18204	45	APOE,SLC1A3,GRIK2,ANK2
2.106e-02	-3.86	heparan sulfate biosynthesis (late stages)	BIOCYC pathways	HUMAN_PWY-6558	19	1	902	1	GLCE
2.110e-02	-3.86	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	1	14470	44	SLC1A3
2.112e-02	-3.86	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	7	19454	49	SYT1,ANK2,SLC1A3,LSAMP,NRG1,APOE,TRPM3
2.133e-02	-3.85	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	46	16828	48	RELN,RIMS1,ZNF385B,KIF21A,CDH18,CADPS2,GRID2,SYT1,NPAS3,NRXN1,SLC1A3,CHN2,PCDH9,NFIA,ST18,LRRTM4,STXBP5L,ZNF385D,KCNJ3,SLC35F3,NRG1,RUNX1T1,RALYL,RIMS2,NRG3,TRPM3,CNTN4,GPC6,LSAMP,UNC5C,DTNA,NRXN3,EPHA5,CACNA2D1,GLCE,PTPRG,CNTN5,GRIK2,ANK2,LINGO2,CNTNAP2,MYT1L,FSTL5,EBF1,TLL1,GRIA4
2.135e-02	-3.85	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-T_cell_large_granular_lymphocytic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-T_cell_large_granular_lymphocytic_leukaemia	79	2	16828	48	NRG1,LINGO2
2.151e-02	-3.84	voltage-gated potassium channel complex	cellular component	GO:0008076	90	2	19108	48	KCNJ3,CNTNAP2
2.162e-02	-3.83	PLXNA3 (plexin A3)	protein interactions	55558	90	2	19454	49	KIF21A,NRG1
2.162e-02	-3.83	ASTACIN	prints domains	PR00480	6	1	5227	19	TLL1
2.183e-02	-3.82	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	45	GRIK2,ANK2,SLC1A3,APOE
2.203e-02	-3.82	SA node cell to atrial cardiac muscle cell communication	biological process	GO:0086070	9	1	18204	45	ANK2
2.203e-02	-3.82	sterol catabolic process	biological process	GO:0016127	9	1	18204	45	APOE
2.203e-02	-3.82	ERBB2-ERBB3 signaling pathway	biological process	GO:0038133	9	1	18204	45	NRG1
2.203e-02	-3.82	protein localization to axon	biological process	GO:0099612	9	1	18204	45	CNTNAP2
2.203e-02	-3.82	ERBB3 signaling pathway	biological process	GO:0038129	9	1	18204	45	NRG1
2.203e-02	-3.82	netrin-activated signaling pathway	biological process	GO:0038007	9	1	18204	45	UNC5C
2.203e-02	-3.82	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	45	APOE
2.203e-02	-3.82	cerebellar granular layer morphogenesis	biological process	GO:0021683	9	1	18204	45	GRID2
2.207e-02	-3.81	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	49	SYT1,ANK2
2.224e-02	-3.81	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-fibula-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	377	4	16828	48	EPHA5,NRXN1,RIMS1,TRPM3
2.224e-02	-3.81	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	10	19454	49	TLL1,DTNA,NFIA,PTPRG,NRG3,KCNJ3,ZNF385B,GRIK2,RIMS1,STXBP5L
2.227e-02	-3.80	human chr8q11.23	chromosome location	human chr8q11.23	12	1	26134	49	ST18
2.237e-02	-3.80	T_cell_large_granular_lymphocytic_leukaemia	COSMIC cancer mutations	T_cell_large_granular_lymphocytic_leukaemia	81	2	16828	48	NRG1,LINGO2
2.239e-02	-3.80	chromaffin granule membrane	cellular component	GO:0042584	9	1	19108	48	SYT1
2.239e-02	-3.80	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	12	APOE
2.244e-02	-3.80	stomach	COSMIC cancer mutations	stomach	15550	48	16828	48	RELN,ZNF385B,APOE,RIMS1,GRID2,CDH18,CADPS2,KIF21A,SYT1,NRXN1,NPAS3,CHN2,SLC1A3,ST18,NFIA,PCDH9,STXBP5L,LRRTM4,CST3,KCNJ3,ZNF385D,RALYL,RUNX1T1,NRG1,SLC35F3,RIMS2,TRPM3,NRG3,CNTN4,GPC6,NRXN3,DTNA,UNC5C,LSAMP,EPHA5,CACNA2D1,PTPRG,GLCE,CNTN5,ANK2,GRIK2,LINGO2,CNTNAP2,MYT1L,FSTL5,EBF1,GRIA4,TLL1
2.245e-02	-3.80	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	49	APOE
2.245e-02	-3.80	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	1	19454	49	LSAMP
2.245e-02	-3.80	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	1	19454	49	LSAMP
2.245e-02	-3.80	Plk2 (polo like kinase 2)	protein interactions	20620	9	1	19454	49	CACNA2D1
2.245e-02	-3.80	Ubc (ubiquitin C)	protein interactions	50522	9	1	19454	49	STXBP5L
2.245e-02	-3.80	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	49	APOE
2.249e-02	-3.79	large_intestine-rectum	COSMIC cancer mutations	large_intestine-rectum	569	5	16828	48	ZNF385D,GPC6,NRXN3,PTPRG,RUNX1T1
2.249e-02	-3.79	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	4	18204	45	GRIK2,ANK2,SLC1A3,APOE
2.249e-02	-3.79	postsynapse	cellular component	GO:0098794	646	5	19108	48	GRID2,ANK2,GRIK2,LRRTM4,GRIA4
2.276e-02	-3.78	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	1	12186	40	SLC1A3
2.276e-02	-3.78	MHD1	prosite domains	PS51258	7	1	12186	40	CADPS2
2.276e-02	-3.78	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	1	12186	40	SLC1A3
2.286e-02	-3.78	clathrin-coated endocytic vesicle	cellular component	GO:0045334	93	2	19108	48	APOE,SYT1
2.307e-02	-3.77	hippocampus development	biological process	GO:0021766	95	2	18204	45	RELN,EPHA5
2.345e-02	-3.75	LMAN2L (lectin, mannose binding 2 like)	protein interactions	81562	94	2	19454	49	CACNA2D1,LINGO2
2.351e-02	-3.75	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	45	APOE,PTPRG,GRID2,RELN
2.357e-02	-3.75	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	49	CST3
2.402e-02	-3.73	calcium ion transport	biological process	GO:0006816	251	3	18204	45	ANK2,CACNA2D1,TRPM3
2.420e-02	-3.72	fibula	COSMIC cancer mutations	fibula	387	4	16828	48	EPHA5,NRXN1,RIMS1,TRPM3
2.445e-02	-3.71	cellular response to cocaine	biological process	GO:0071314	10	1	18204	45	SLC1A3
2.445e-02	-3.71	regulation of gap junction assembly	biological process	GO:1903596	10	1	18204	45	CNTNAP2
2.445e-02	-3.71	regulation of high voltage-gated calcium channel activity	biological process	GO:1901841	10	1	18204	45	CACNA2D1
2.445e-02	-3.71	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	45	APOE
2.445e-02	-3.71	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	45	APOE
2.445e-02	-3.71	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	45	NRXN1
2.445e-02	-3.71	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	45	APOE
2.445e-02	-3.71	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	45	APOE
2.445e-02	-3.71	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	45	APOE
2.445e-02	-3.71	inhibitory postsynaptic potential	biological process	GO:0060080	10	1	18204	45	GRIK2
2.445e-02	-3.71	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	45	APOE
2.445e-02	-3.71	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	45	NRXN1
2.445e-02	-3.71	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	45	NRG3
2.445e-02	-3.71	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	45	NRG3
2.450e-02	-3.71	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	48	GRIA4,FSTL5,STXBP5L,CDH18,KIF21A
2.452e-02	-3.71	regulation of transporter activity	biological process	GO:0032409	253	3	18204	45	ANK2,RELN,CACNA2D1
2.483e-02	-3.70	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	11	16828	48	KCNJ3,NRG3,CNTN4,RELN,RIMS2,EPHA5,NRG1,RUNX1T1,GLCE,UNC5C,EBF1
2.483e-02	-3.70	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	11	16828	48	NRG1,RUNX1T1,GLCE,UNC5C,EBF1,KCNJ3,NRG3,CNTN4,RELN,RIMS2,EPHA5
2.491e-02	-3.69	C6orf136 (chromosome 6 open reading frame 136)	protein interactions	221545	10	1	19454	49	KIF21A
2.491e-02	-3.69	ALKAL2 (ALK and LTK ligand 2)	protein interactions	285016	10	1	19454	49	CACNA2D1
2.491e-02	-3.69	RAB37 (RAB37, member RAS oncogene family)	protein interactions	326624	10	1	19454	49	RIMS1
2.495e-02	-3.69	cellular localization	biological process	GO:0051641	2660	12	18204	45	APOE,GRIK2,RELN,CADPS2,CNTNAP2,SYT1,STXBP5L,GRID2,ANK2,RIMS1,RIMS2,NRXN1
2.501e-02	-3.69	lung-carcinoma-mixed_small_cell_carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-mixed_small_cell_carcinoma-adenocarcinoma	86	2	16828	48	NRXN3,ANK2
2.516e-02	-3.68	amide binding	molecular function	GO:0033218	254	3	18094	45	APOE,CST3,GRIA4
2.518e-02	-3.68	EDTRNSPORT	prints domains	PR00173	7	1	5227	19	SLC1A3
2.528e-02	-3.68	positive regulation of growth	biological process	GO:0045927	256	3	18204	45	SYT1,RIMS1,RIMS2
2.534e-02	-3.68	DMD (dystrophin)	protein interactions	1756	98	2	19454	49	CADPS2,DTNA
2.550e-02	-3.67	heparan sulfate biosynthesis	BIOCYC pathways	META_PWY-6564	23	1	902	1	GLCE
2.555e-02	-3.67	regulation of cellular process	biological process	GO:0050794	11468	35	18204	45	CADPS2,GRIK2,PTPRG,UNC5C,EBF1,ST18,NPAS3,LINGO2,RIMS1,NFIA,ZNF385B,CHN2,CACNA2D1,ANK2,NRG3,RUNX1T1,RELN,SLC1A3,CNTNAP2,GLCE,NRG1,GRIA4,APOE,GPC6,RIMS2,EPHA5,NRXN1,GRID2,CST3,CNTN4,MYT1L,FSTL5,SYT1,DTNA,KCNJ3
2.555e-02	-3.67	mixed_small_cell_carcinoma-adenocarcinoma	COSMIC cancer mutations	mixed_small_cell_carcinoma-adenocarcinoma	87	2	16828	48	NRXN3,ANK2
2.580e-02	-3.66	regulation of nervous system development	biological process	GO:0051960	456	4	18204	45	RELN,GRID2,LINGO2,NRXN1
2.591e-02	-3.65	positive regulation of molecular function	biological process	GO:0044093	1192	7	18204	45	EPHA5,RELN,ST18,NRG1,APOE,CACNA2D1,ANK2
2.594e-02	-3.65	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	49	NRXN1
2.594e-02	-3.65	human chr3p14.2	chromosome location	human chr3p14.2	14	1	26134	49	PTPRG
2.596e-02	-3.65	Anchoring fibril formation	REACTOME pathways	R-HSA-2214320	9	1	10285	30	TLL1
2.596e-02	-3.65	Crosslinking of collagen fibrils	REACTOME pathways	R-HSA-2243919	9	1	10285	30	TLL1
2.597e-02	-3.65	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	45	GLCE,GRID2,RELN,APOE,PTPRG
2.611e-02	-3.65	PAS_3	pfam domains	PF08447	10	1	17795	47	NPAS3
2.611e-02	-3.65	FYVE_2	pfam domains	PF02318	10	1	17795	47	RIMS2
2.615e-02	-3.64	PAS_fold_3	interpro domains	IPR013655	10	1	18521	49	NPAS3
2.615e-02	-3.64	FYVE_2	interpro domains	IPR041282	10	1	18521	49	RIMS2
2.616e-02	-3.64	extrinsic component of plasma membrane	cellular component	GO:0019897	100	2	19108	48	CDH18,DTNA
2.619e-02	-3.64	peptide binding	molecular function	GO:0042277	258	3	18094	45	GRIA4,APOE,CST3
2.639e-02	-3.63	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	30	NRG3,NRG1
2.657e-02	-3.63	regulation of blood circulation	biological process	GO:1903522	261	3	18204	45	KCNJ3,ANK2,CACNA2D1
2.687e-02	-3.62	L-glutamate import across plasma membrane	biological process	GO:0098712	11	1	18204	45	SLC1A3
2.687e-02	-3.62	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	45	APOE
2.687e-02	-3.62	regulation of membrane repolarization during action potential	biological process	GO:0098903	11	1	18204	45	CACNA2D1
2.687e-02	-3.62	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	45	NRG3
2.687e-02	-3.62	regulation of fear response	biological process	GO:1903365	11	1	18204	45	APOE
2.687e-02	-3.62	ectodermal placode formation	biological process	GO:0060788	11	1	18204	45	NRG3
2.687e-02	-3.62	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0098696	11	1	18204	45	GPC6
2.687e-02	-3.62	heparin biosynthetic process	biological process	GO:0030210	11	1	18204	45	GLCE
2.687e-02	-3.62	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	45	APOE
2.687e-02	-3.62	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	45	NRG3
2.687e-02	-3.62	cardiac muscle cell myoblast differentiation	biological process	GO:0060379	11	1	18204	45	NRG1
2.687e-02	-3.62	L-aspartate transmembrane transport	biological process	GO:0070778	11	1	18204	45	SLC1A3
2.703e-02	-3.61	racemase and epimerase activity, acting on carbohydrates and derivatives	molecular function	GO:0016857	11	1	18094	45	GLCE
2.703e-02	-3.61	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0099508	11	1	18094	45	KCNJ3
2.703e-02	-3.61	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	45	NRXN1
2.704e-02	-3.61	-	gene3d domains	1.10.357.50	9	1	14470	44	CADPS2
2.711e-02	-3.61	macromolecule localization	biological process	GO:0033036	2376	11	18204	45	CADPS2,RIMS2,RELN,GRIK2,RIMS1,NRXN1,CNTNAP2,STXBP5L,ANK2,GRID2,APOE
2.722e-02	-3.60	DEATH-like_dom_sf	interpro domains	IPR011029	97	2	18521	49	ANK2,UNC5C
2.728e-02	-3.60	TMPRSS13 (transmembrane serine protease 13)	protein interactions	84000	102	2	19454	49	GLCE,GPC6
2.729e-02	-3.60	inorganic cation import across plasma membrane	biological process	GO:0098659	104	2	18204	45	KCNJ3,CACNA2D1
2.729e-02	-3.60	inorganic ion import across plasma membrane	biological process	GO:0099587	104	2	18204	45	CACNA2D1,KCNJ3
2.737e-02	-3.60	DUS4L (dihydrouridine synthase 4 like)	protein interactions	11062	11	1	19454	49	PTPRG
2.737e-02	-3.60	C22orf42 (chromosome 22 open reading frame 42)	protein interactions	150297	11	1	19454	49	EPHA5
2.737e-02	-3.60	PLA2G5 (phospholipase A2 group V)	protein interactions	5322	11	1	19454	49	CACNA2D1
2.737e-02	-3.60	PIP5K1P1 (phosphatidylinositol-4-phosphate 5-kinase type 1 pseudogene 1)	protein interactions	206426	11	1	19454	49	NRXN3
2.737e-02	-3.60	TAL2 (TAL bHLH transcription factor 2)	protein interactions	6887	11	1	19454	49	RUNX1T1
2.737e-02	-3.60	Katna1 (katanin p60 (ATPase-containing) subunit A1)	protein interactions	23924	11	1	19454	49	RIMS1
2.737e-02	-3.60	Kif21b (kinesin family member 21B)	protein interactions	16565	11	1	19454	49	KIF21A
2.737e-02	-3.60	SV2C (synaptic vesicle glycoprotein 2C)	protein interactions	22987	11	1	19454	49	SYT1
2.737e-02	-3.60	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	49	NRXN1
2.737e-02	-3.60	Caskin1 (CASK interacting protein 1)	protein interactions	140722	11	1	19454	49	SYT1
2.746e-02	-3.60	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	3	16828	48	RIMS2,UNC5C,MYT1L
2.758e-02	-3.59	ErbB signaling pathway	KEGG pathways	hsa04012	85	2	7161	22	NRG1,NRG3
2.758e-02	-3.59	ErbB signaling pathway	KEGG pathways	ko04012	85	2	7161	22	NRG3,NRG1
2.765e-02	-3.59	regulation of monoatomic ion transport	biological process	GO:0043269	466	4	18204	45	KCNJ3,CACNA2D1,RELN,ANK2
2.772e-02	-3.59	heparan sulfate biosynthesis	BIOCYC pathways	HUMAN_PWY-6564	25	1	902	1	GLCE
2.777e-02	-3.58	human chr12q21.2	chromosome location	human chr12q21.2	15	1	26134	49	SYT1
2.800e-02	-3.58	CTNNB1 (catenin beta 1)	protein interactions	1499	926	6	19454	49	DTNA,CDH18,APOE,EPHA5,ANK2,GRIK2
2.801e-02	-3.58	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	48	EBF1,ANK2,RIMS1,ST18,NRXN3
2.811e-02	-3.57	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	30	NRG1,NRG3
2.828e-02	-3.57	RRP7A (ribosomal RNA processing 7 homolog A)	protein interactions	27341	104	2	19454	49	SYT1,NFIA
2.844e-02	-3.56	EphrinA-EPHA pathway	Pathway Interaction DB	ephrina_ephapathway	8	1	2226	8	EPHA5
2.868e-02	-3.55	SBP_bac_3	pfam domains	PF00497	11	1	17795	47	GRIA4
2.873e-02	-3.55	Solute-binding_3/MltF_N	interpro domains	IPR001638	11	1	18521	49	GRIA4
2.880e-02	-3.55	Neurotoxicity of clostridium toxins	REACTOME pathways	R-HSA-168799	10	1	10285	30	SYT1
2.880e-02	-3.55	Netrin mediated repulsion signals	REACTOME pathways	R-HSA-418886	10	1	10285	30	UNC5C
2.887e-02	-3.54	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	3	18094	45	SLC1A3,GRIK2,GRIA4
2.891e-02	-3.54	central_nervous_system-thalamus-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-thalamus-glioma-astrocytoma_Grade_IV	93	2	16828	48	EBF1,GRIA4
2.917e-02	-3.53	CYSTATIN	prosite domains	PS00287	9	1	12186	40	CST3
2.927e-02	-3.53	regulation of synaptic vesicle membrane organization	biological process	GO:1901632	12	1	18204	45	SYT1
2.927e-02	-3.53	positive regulation of catecholamine secretion	biological process	GO:0033605	12	1	18204	45	SYT1
2.927e-02	-3.53	ventricular cardiac muscle cell membrane repolarization	biological process	GO:0099625	12	1	18204	45	KCNJ3
2.927e-02	-3.53	regulation of synaptic vesicle fusion to presynaptic active zone membrane	biological process	GO:0031630	12	1	18204	45	SYT1
2.927e-02	-3.53	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	biological process	GO:2001267	12	1	18204	45	ST18
2.927e-02	-3.53	neuronal ion channel clustering	biological process	GO:0045161	12	1	18204	45	CNTNAP2
2.927e-02	-3.53	membrane repolarization during ventricular cardiac muscle cell action potential	biological process	GO:0098915	12	1	18204	45	KCNJ3
2.927e-02	-3.53	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	45	CST3
2.927e-02	-3.53	endocardium development	biological process	GO:0003157	12	1	18204	45	NRG1
2.927e-02	-3.53	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	45	CST3
2.945e-02	-3.53	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	molecular function	GO:1902282	12	1	18094	45	KCNJ3
2.959e-02	-3.52	human chr2q24.1	chromosome location	human chr2q24.1	16	1	26134	49	KCNJ3
2.963e-02	-3.52	enzyme binding	molecular function	GO:0019899	2086	10	18094	45	RIMS1,NRG3,NRG1,CNTNAP2,UNC5C,ANK2,CST3,APOE,GRIK2,RIMS2
2.971e-02	-3.52	nitrogen compound transport	biological process	GO:0071705	1507	8	18204	45	APOE,ANK2,STXBP5L,SLC1A3,SLC35F3,RIMS2,CADPS2,RIMS1
2.972e-02	-3.52	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	11	16828	48	ANK2,RELN,STXBP5L,SYT1,DTNA,RUNX1T1,KIF21A,EPHA5,NFIA,PTPRG,FSTL5
2.974e-02	-3.52	clathrin-sculpted vesicle	cellular component	GO:0060198	12	1	19108	48	SYT1
2.974e-02	-3.52	L-type voltage-gated calcium channel complex	cellular component	GO:1990454	12	1	19108	48	CACNA2D1
2.974e-02	-3.52	paranode region of axon	cellular component	GO:0033270	12	1	19108	48	CNTNAP2
2.974e-02	-3.52	juxtaparanode region of axon	cellular component	GO:0044224	12	1	19108	48	CNTNAP2
2.982e-02	-3.51	CACNA1S (calcium voltage-gated channel subunit alpha1 S)	protein interactions	779	12	1	19454	49	RIMS2
2.982e-02	-3.51	ISG20 (interferon stimulated exonuclease gene 20)	protein interactions	3669	12	1	19454	49	PTPRG
2.982e-02	-3.51	CDH9 (cadherin 9)	protein interactions	1007	12	1	19454	49	CDH18
2.982e-02	-3.51	TIGD3 (tigger transposable element derived 3)	protein interactions	220359	12	1	19454	49	RALYL
2.982e-02	-3.51	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	49	APOE
3.007e-02	-3.50	haemangiopericytic	COSMIC cancer mutations	haemangiopericytic	95	2	16828	48	KCNJ3,SLC35F3
3.007e-02	-3.50	meninges-meningioma-haemangiopericytic	COSMIC cancer mutations	meninges-meningioma-haemangiopericytic	95	2	16828	48	SLC35F3,KCNJ3
3.031e-02	-3.50	DRD2 (dopamine receptor D2)	protein interactions	1813	108	2	19454	49	CADPS2,KCNJ3
3.031e-02	-3.50	CAMKV (CaM kinase like vesicle associated)	protein interactions	79012	108	2	19454	49	GPC6,NRXN3
3.032e-02	-3.50	Glycosaminoglycan biosynthesis, heparan sulfate backbone	KEGG pathways	M00059	10	1	7161	22	GLCE
3.032e-02	-3.50	Glycosaminoglycan biosynthesis, heparan sulfate backbone	KEGG pathways	hsa_M00059	10	1	7161	22	GLCE
3.040e-02	-3.49	Ig_E-set	interpro domains	IPR014756	103	2	18521	49	EBF1,KCNJ3
3.046e-02	-3.49	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	30	NRG3,NRG1
3.065e-02	-3.49	tibia	COSMIC cancer mutations	tibia	836	6	16828	48	FSTL5,CNTN5,LRRTM4,TRPM3,NRXN3,LSAMP
3.067e-02	-3.48	cortical cytoskeleton	cellular component	GO:0030863	109	2	19108	48	RIMS2,RIMS1
3.112e-02	-3.47	distal axon	cellular component	GO:0150034	273	3	19108	48	GRIK2,UNC5C,PCDH9
3.125e-02	-3.47	MH1	pfam domains	PF03165	12	1	17795	47	NFIA
3.130e-02	-3.46	V_SNARE_CC	interpro domains	IPR042855	12	1	18521	49	STXBP5L
3.130e-02	-3.46	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	49	NFIA
3.139e-02	-3.46	regulation of transmembrane transport	biological process	GO:0034762	485	4	18204	45	CACNA2D1,RELN,ANK2,KCNJ3
3.167e-02	-3.45	thalamus development	biological process	GO:0021794	13	1	18204	45	CNTNAP2
3.167e-02	-3.45	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	45	NRXN1
3.167e-02	-3.45	detection of calcium ion	biological process	GO:0005513	13	1	18204	45	SYT1
3.167e-02	-3.45	regulation of postsynaptic density assembly	biological process	GO:0099151	13	1	18204	45	GRID2
3.167e-02	-3.45	positive regulation of calcium ion-dependent exocytosis	biological process	GO:0045956	13	1	18204	45	SYT1
3.167e-02	-3.45	glial cell fate commitment	biological process	GO:0021781	13	1	18204	45	NFIA
3.167e-02	-3.45	phospholipid efflux	biological process	GO:0033700	13	1	18204	45	APOE
3.167e-02	-3.45	cerebellar granular layer development	biological process	GO:0021681	13	1	18204	45	GRID2
3.167e-02	-3.45	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	1	18204	45	APOE
3.167e-02	-3.45	ectodermal placode development	biological process	GO:0071696	13	1	18204	45	NRG3
3.167e-02	-3.45	calcium ion transport into cytosol	biological process	GO:0060402	13	1	18204	45	CACNA2D1
3.167e-02	-3.45	motor neuron migration	biological process	GO:0097475	13	1	18204	45	RELN
3.167e-02	-3.45	cardioblast differentiation	biological process	GO:0010002	13	1	18204	45	NRG1
3.167e-02	-3.45	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	45	APOE
3.172e-02	-3.45	extracellular region	cellular component	GO:0005576	4350	17	19108	48	NRG1,LINGO2,RIMS2,GRIA4,GPC6,NRG3,CNTN4,CST3,FSTL5,LRRTM4,CACNA2D1,PTPRG,TLL1,APOE,CNTN5,RELN,LSAMP
3.186e-02	-3.45	myosin II binding	molecular function	GO:0045159	13	1	18094	45	STXBP5L
3.218e-02	-3.44	chylomicron	cellular component	GO:0042627	13	1	19108	48	APOE
3.226e-02	-3.43	ACBD7 (acyl-CoA binding domain containing 7)	protein interactions	414149	13	1	19454	49	PTPRG
3.226e-02	-3.43	KCNJ3 (potassium inwardly rectifying channel subfamily J member 3)	protein interactions	3760	13	1	19454	49	KCNJ3
3.226e-02	-3.43	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	49	NFIA
3.226e-02	-3.43	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	49	APOE
3.226e-02	-3.43	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	49	RIMS2
3.226e-02	-3.43	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	49	NRXN1
3.241e-02	-3.43	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	49	RALYL,RUNX1T1
3.243e-02	-3.43	large_intestine-rectum-adenoma	COSMIC cancer mutations	large_intestine-rectum-adenoma	99	2	16828	48	RELN,CNTN4
3.253e-02	-3.43	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	49	SYT1,SLC1A3,NRG1
3.298e-02	-3.41	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	5	19454	49	RIMS2,SLC1A3,PTPRG,ANK2,DTNA
3.323e-02	-3.40	human chr7q21.11	chromosome location	human chr7q21.11	18	1	26134	49	CACNA2D1
3.323e-02	-3.40	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	49	CADPS2
3.335e-02	-3.40	regulation of cation channel activity	biological process	GO:2001257	116	2	18204	45	ANK2,CACNA2D1
3.347e-02	-3.40	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	49	PCDH9,NRG1
3.349e-02	-3.40	endometrium-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-endometrioid_carcinoma	15680	48	16828	48	NRXN3,DTNA,UNC5C,LSAMP,GPC6,CNTN4,PTPRG,GLCE,CACNA2D1,EPHA5,CNTNAP2,LINGO2,GRIK2,ANK2,CNTN5,GRIA4,TLL1,FSTL5,EBF1,MYT1L,SYT1,GRID2,CADPS2,CDH18,KIF21A,ZNF385B,APOE,RIMS1,RELN,ST18,NFIA,PCDH9,CHN2,SLC1A3,NRXN1,NPAS3,RALYL,RUNX1T1,NRG1,SLC35F3,KCNJ3,ZNF385D,STXBP5L,CST3,LRRTM4,TRPM3,NRG3,RIMS2
3.355e-02	-3.39	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	633	5	16828	48	CDH18,KIF21A,NRXN3,TLL1,UNC5C
3.373e-02	-3.39	Cadherin_CS	interpro domains	IPR020894	109	2	18521	49	CDH18,PCDH9
3.407e-02	-3.38	interneuron migration	biological process	GO:1904936	14	1	18204	45	RELN
3.407e-02	-3.38	regulation of NMDA receptor activity	biological process	GO:2000310	14	1	18204	45	RELN
3.407e-02	-3.38	regulation of long-term synaptic depression	biological process	GO:1900452	14	1	18204	45	GRID2
3.407e-02	-3.38	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	45	APOE
3.407e-02	-3.38	layer formation in cerebral cortex	biological process	GO:0021819	14	1	18204	45	RELN
3.407e-02	-3.38	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	45	APOE
3.407e-02	-3.38	ventricular trabecula myocardium morphogenesis	biological process	GO:0003222	14	1	18204	45	NRG1
3.407e-02	-3.38	bundle of His cell to Purkinje myocyte communication	biological process	GO:0086069	14	1	18204	45	CACNA2D1
3.407e-02	-3.38	dendrite self-avoidance	biological process	GO:0070593	14	1	18204	45	CNTN4
3.407e-02	-3.38	interleukin-6-mediated signaling pathway	biological process	GO:0070102	14	1	18204	45	ST18
3.422e-02	-3.37	transmembrane transport	biological process	GO:0055085	1264	7	18204	45	GRIK2,SLC1A3,GRID2,CACNA2D1,TRPM3,KCNJ3,GRIA4
3.426e-02	-3.37	calcium channel activity	molecular function	GO:0005262	117	2	18094	45	CACNA2D1,TRPM3
3.427e-02	-3.37	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	1	18094	45	SLC1A3
3.440e-02	-3.37	Death Domain, Fas	gene3d domains	1.10.533.10	96	2	14470	44	ANK2,UNC5C
3.441e-02	-3.37	regulation of multicellular organismal process	biological process	GO:0051239	3113	13	18204	45	ANK2,CST3,GRID2,CACNA2D1,KCNJ3,LINGO2,RIMS1,RIMS2,NRXN1,APOE,GRIK2,RELN,PTPRG
3.441e-02	-3.37	negative regulation of epithelial cell migration	biological process	GO:0010633	118	2	18204	45	PTPRG,APOE
3.441e-02	-3.37	positive regulation of calcium ion transport	biological process	GO:0051928	118	2	18204	45	ANK2,CACNA2D1
3.446e-02	-3.37	Ionotropic activity of Kainate Receptors	REACTOME pathways	R-HSA-451306	12	1	10285	30	GRIK2
3.446e-02	-3.37	Activation of Ca-permeable Kainate Receptor	REACTOME pathways	R-HSA-451308	12	1	10285	30	GRIK2
3.446e-02	-3.37	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	30	GPC6
3.446e-02	-3.37	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	30	GPC6
3.452e-02	-3.37	Circadian entrainment	KEGG pathways	ko04713	96	2	7161	22	GRIA4,KCNJ3
3.452e-02	-3.37	Circadian entrainment	KEGG pathways	hsa04713	96	2	7161	22	GRIA4,KCNJ3
3.453e-02	-3.37	endometrioid_carcinoma	COSMIC cancer mutations	endometrioid_carcinoma	15690	48	16828	48	PTPRG,GLCE,EPHA5,CACNA2D1,DTNA,NRXN3,LSAMP,UNC5C,CNTN4,GPC6,EBF1,FSTL5,TLL1,GRIA4,MYT1L,LINGO2,CNTNAP2,CNTN5,ANK2,GRIK2,ST18,NFIA,PCDH9,NRXN1,NPAS3,CHN2,SLC1A3,GRID2,KIF21A,CDH18,CADPS2,SYT1,RELN,APOE,ZNF385B,RIMS1,RIMS2,TRPM3,NRG3,NRG1,RUNX1T1,RALYL,SLC35F3,STXBP5L,LRRTM4,CST3,KCNJ3,ZNF385D
3.461e-02	-3.36	chromaffin granule	cellular component	GO:0042583	14	1	19108	48	SYT1
3.470e-02	-3.36	CSF3 (colony stimulating factor 3)	protein interactions	1440	14	1	19454	49	PTPRG
3.470e-02	-3.36	CHGA (chromogranin A)	protein interactions	1113	14	1	19454	49	SYT1
3.470e-02	-3.36	C9 (complement C9)	protein interactions	735	14	1	19454	49	APOE
3.470e-02	-3.36	GRID2 (glutamate ionotropic receptor delta type subunit 2)	protein interactions	2895	14	1	19454	49	GRIK2
3.470e-02	-3.36	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	49	APOE
3.470e-02	-3.36	OTUD7A (OTU deubiquitinase 7A)	protein interactions	161725	14	1	19454	49	ANK2
3.470e-02	-3.36	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	49	CST3
3.474e-02	-3.36	endometrium	COSMIC cancer mutations	endometrium	15692	48	16828	48	SYT1,CADPS2,CDH18,KIF21A,GRID2,RIMS1,ZNF385B,APOE,RELN,PCDH9,NFIA,ST18,SLC1A3,CHN2,NPAS3,NRXN1,SLC35F3,RALYL,RUNX1T1,NRG1,ZNF385D,KCNJ3,CST3,LRRTM4,STXBP5L,NRG3,TRPM3,RIMS2,UNC5C,LSAMP,NRXN3,DTNA,GPC6,CNTN4,GLCE,PTPRG,CACNA2D1,EPHA5,CNTNAP2,LINGO2,ANK2,GRIK2,CNTN5,GRIA4,TLL1,EBF1,FSTL5,MYT1L
3.475e-02	-3.36	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	2	10285	30	GPC6,APOE
3.510e-02	-3.35	cellular component assembly	biological process	GO:0022607	2472	11	18204	45	CNTN5,TRPM3,NRG1,APOE,CDH18,NRG3,SYT1,ANK2,GRID2,RIMS1,NRXN1
3.531e-02	-3.34	Cadherin	pfam domains	PF00028	112	2	17795	47	PCDH9,CDH18
3.558e-02	-3.34	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	3	19454	49	PTPRG,DTNA,EPHA5
3.563e-02	-3.33	monoatomic cation homeostasis	biological process	GO:0055080	505	4	18204	45	APOE,SLC1A3,GRIK2,ANK2
3.565e-02	-3.33	CEACAM8 (CEA cell adhesion molecule 8)	protein interactions	1088	118	2	19454	49	CACNA2D1,APOE
3.567e-02	-3.33	OCLN (occludin)	protein interactions	100506658	495	4	19454	49	PTPRG,ANK2,DTNA,CCSER1
3.572e-02	-3.33	skin-sole-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-sole-malignant_melanoma-acral_lentiginous	254	3	16828	48	CDH18,ST18,CNTNAP2
3.620e-02	-3.32	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	49	APOE,PCDH9
3.636e-02	-3.31	EphA2_TM	pfam domains	PF14575	14	1	17795	47	EPHA5
3.636e-02	-3.31	Ephrin_lbd	pfam domains	PF01404	14	1	17795	47	EPHA5
3.642e-02	-3.31	Tyr_kinase_rcpt_V_CS	interpro domains	IPR001426	14	1	18521	49	EPHA5
3.642e-02	-3.31	Tyr_kinase_ephrin_rcpt	interpro domains	IPR016257	14	1	18521	49	EPHA5
3.642e-02	-3.31	Eph_TM	interpro domains	IPR027936	14	1	18521	49	EPHA5
3.642e-02	-3.31	Ephrin_rcpt_lig-bd_dom	interpro domains	IPR001090	14	1	18521	49	EPHA5
3.646e-02	-3.31	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	45	APOE
3.646e-02	-3.31	regulation of phospholipid transport	biological process	GO:2001138	15	1	18204	45	APOE
3.646e-02	-3.31	exit from mitosis	biological process	GO:0010458	15	1	18204	45	NFIA
3.646e-02	-3.31	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	45	ANK2
3.646e-02	-3.31	dense core granule localization	biological process	GO:0032253	15	1	18204	45	CADPS2
3.646e-02	-3.31	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	45	APOE
3.646e-02	-3.31	synapse maturation	biological process	GO:0060074	15	1	18204	45	NFIA
3.660e-02	-3.31	Cadherin-like_dom	interpro domains	IPR002126	114	2	18521	49	CDH18,PCDH9
3.668e-02	-3.31	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	molecular function	GO:0086008	15	1	18094	45	KCNJ3
3.668e-02	-3.31	transmembrane-ephrin receptor activity	molecular function	GO:0005005	15	1	18094	45	EPHA5
3.669e-02	-3.31	vesicle-mediated transport	biological process	GO:0016192	1283	7	18204	45	RIMS2,CADPS2,STXBP5L,ANK2,RIMS1,SYT1,APOE
3.697e-02	-3.30	potassium channel activity	molecular function	GO:0005267	122	2	18094	45	GRIK2,KCNJ3
3.704e-02	-3.30	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	48	APOE
3.704e-02	-3.30	axolemma	cellular component	GO:0030673	15	1	19108	48	CNTNAP2
3.714e-02	-3.29	Sgo1 (shugoshin 1)	protein interactions	72415	15	1	19454	49	RIMS1
3.714e-02	-3.29	EBF1 (EBF transcription factor 1)	protein interactions	1879	15	1	19454	49	EBF1
3.714e-02	-3.29	DEFB123 (defensin beta 123)	protein interactions	245936	15	1	19454	49	CACNA2D1
3.714e-02	-3.29	BSN (bassoon presynaptic cytomatrix protein)	protein interactions	8927	15	1	19454	49	RIMS1
3.714e-02	-3.29	TMEM181 (transmembrane protein 181)	protein interactions	57583	15	1	19454	49	NRG1
3.728e-02	-3.29	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	REACTOME pathways	R-HSA-112308	13	1	10285	30	CACNA2D1
3.728e-02	-3.29	Downregulation of ERBB2:ERBB3 signaling	REACTOME pathways	R-HSA-1358803	13	1	10285	30	NRG1
3.778e-02	-3.28	Cadherin-like_sf	interpro domains	IPR015919	116	2	18521	49	PCDH9,CDH18
3.782e-02	-3.27	regulation of cellular component biogenesis	biological process	GO:0044087	1016	6	18204	45	NRXN1,NRG1,APOE,CNTNAP2,GRID2,LINGO2
3.787e-02	-3.27	monoatomic ion homeostasis	biological process	GO:0050801	515	4	18204	45	APOE,SLC1A3,GRIK2,ANK2
3.788e-02	-3.27	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	49	EPHA5,DTNA
3.822e-02	-3.26	cerebral cortex development	biological process	GO:0021987	125	2	18204	45	RELN,CNTNAP2
3.822e-02	-3.26	mammary gland development	biological process	GO:0030879	125	2	18204	45	NRG3,NRG1
3.822e-02	-3.26	memory	biological process	GO:0007613	125	2	18204	45	RELN,APOE
3.864e-02	-3.25	protein tyrosine kinase binding	molecular function	GO:1990782	125	2	18094	45	NRG3,NRG1
3.866e-02	-3.25	human chr4q32.3	chromosome location	human chr4q32.3	21	1	26134	49	TLL1
3.866e-02	-3.25	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	49	NRG3
3.870e-02	-3.25	V_SNARE	prosite domains	PS50892	12	1	12186	40	STXBP5L
3.876e-02	-3.25	H2BC9 (H2B clustered histone 9)	protein interactions	8345	297	3	19454	49	ZNF385B,ST18,NRG1
3.884e-02	-3.25	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	47	16828	48	MYT1L,GRIA4,TLL1,EBF1,FSTL5,ANK2,GRIK2,CNTN5,CNTNAP2,LINGO2,CACNA2D1,EPHA5,GLCE,PTPRG,GPC6,CNTN4,UNC5C,LSAMP,NRXN3,DTNA,NRG3,TRPM3,RIMS2,ZNF385D,KCNJ3,LRRTM4,STXBP5L,SLC35F3,RALYL,NRG1,RUNX1T1,SLC1A3,CHN2,NPAS3,NRXN1,PCDH9,ST18,NFIA,RIMS1,ZNF385B,APOE,RELN,SYT1,CDH18,CADPS2,KIF21A,GRID2
3.884e-02	-3.25	regulation of postsynaptic specialization assembly	biological process	GO:0099150	16	1	18204	45	GRID2
3.884e-02	-3.25	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	45	SLC1A3
3.884e-02	-3.25	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	45	APOE
3.884e-02	-3.25	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	45	APOE
3.884e-02	-3.25	regulation of short-term neuronal synaptic plasticity	biological process	GO:0048172	16	1	18204	45	GRIK2
3.884e-02	-3.25	glutamatergic neuron differentiation	biological process	GO:1905962	16	1	18204	45	GRID2
3.884e-02	-3.25	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	45	APOE
3.898e-02	-3.24	cellular component organization	biological process	GO:0016043	5636	20	18204	45	CST3,GRID2,ANK2,SYT1,CNTN4,NRG3,NRXN3,RIMS1,EPHA5,NFIA,NRXN1,CNTN5,APOE,NRG1,TRPM3,RELN,CDH18,CNTNAP2,UNC5C,TLL1
3.934e-02	-3.24	negative regulation of neuron projection development	biological process	GO:0010977	127	2	18204	45	APOE,PTPRG
3.934e-02	-3.24	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	45	CDH18,ANK2
3.948e-02	-3.23	cell-cell junction	cellular component	GO:0005911	513	4	19108	48	CDH18,PCDH9,CNTNAP2,ANK2
3.956e-02	-3.23	RBM18 (RNA binding motif protein 18)	protein interactions	92400	16	1	19454	49	SYT1
3.956e-02	-3.23	NEUROG1 (neurogenin 1)	protein interactions	4762	16	1	19454	49	RUNX1T1
3.956e-02	-3.23	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	49	CDH18
3.956e-02	-3.23	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	49	NRXN1
3.956e-02	-3.23	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	49	NRXN1
3.956e-02	-3.23	HOXB2 (homeobox B2)	protein interactions	3212	16	1	19454	49	RUNX1T1
3.956e-02	-3.23	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	49	APOE
3.972e-02	-3.23	monoatomic cation transport	biological process	GO:0006812	766	5	18204	45	ANK2,CACNA2D1,SLC1A3,TRPM3,KCNJ3
3.974e-02	-3.23	regulation of small GTPase mediated signal transduction	biological process	GO:0051056	306	3	18204	45	RELN,APOE,CHN2
3.985e-02	-3.22	animal organ development	biological process	GO:0048513	2846	12	18204	45	ANK2,GRID2,CNTN4,NRG3,EPHA5,NFIA,CNTN5,NRG1,PCDH9,RELN,CNTNAP2,UNC5C
4.036e-02	-3.21	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	48	16828	48	TLL1,GRIA4,EBF1,FSTL5,MYT1L,CNTNAP2,LINGO2,ANK2,GRIK2,CNTN5,GLCE,PTPRG,CACNA2D1,EPHA5,LSAMP,UNC5C,DTNA,NRXN3,GPC6,CNTN4,NRG3,TRPM3,RIMS2,SLC35F3,NRG1,RUNX1T1,RALYL,ZNF385D,KCNJ3,LRRTM4,CST3,STXBP5L,PCDH9,ST18,NFIA,SLC1A3,CHN2,NPAS3,NRXN1,SYT1,KIF21A,CADPS2,CDH18,GRID2,RIMS1,APOE,ZNF385B,RELN
4.046e-02	-3.21	human chr3q13.31	chromosome location	human chr3q13.31	22	1	26134	49	LSAMP
4.081e-02	-3.20	enzyme regulator activity	molecular function	GO:0030234	1305	7	18094	45	APOE,CST3,STXBP5L,NRG3,RIMS1,NRG1,CHN2
4.111e-02	-3.19	neuron projection terminus	cellular component	GO:0044306	128	2	19108	48	SYT1,GRIK2
4.122e-02	-3.19	regulation of postsynaptic density organization	biological process	GO:1905874	17	1	18204	45	GRID2
4.122e-02	-3.19	ureter development	biological process	GO:0072189	17	1	18204	45	NFIA
4.122e-02	-3.19	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	45	APOE
4.122e-02	-3.19	regulation of amyloid fibril formation	biological process	GO:1905906	17	1	18204	45	APOE
4.122e-02	-3.19	viral genome replication	biological process	GO:0019079	17	1	18204	45	NFIA
4.122e-02	-3.19	regulation of excitatory synapse assembly	biological process	GO:1904889	17	1	18204	45	GRID2
4.122e-02	-3.19	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	45	APOE
4.122e-02	-3.19	negative regulation of smooth muscle cell apoptotic process	biological process	GO:0034392	17	1	18204	45	GRIA4
4.122e-02	-3.19	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	45	APOE
4.122e-02	-3.19	ganglion development	biological process	GO:0061548	17	1	18204	45	UNC5C
4.122e-02	-3.19	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	45	APOE
4.122e-02	-3.19	positive regulation of neurotransmitter secretion	biological process	GO:0001956	17	1	18204	45	SYT1
4.122e-02	-3.19	reverse cholesterol transport	biological process	GO:0043691	17	1	18204	45	APOE
4.122e-02	-3.19	heparin metabolic process	biological process	GO:0030202	17	1	18204	45	GLCE
4.123e-02	-3.19	sole	COSMIC cancer mutations	sole	269	3	16828	48	CDH18,ST18,CNTNAP2
4.124e-02	-3.19	PDZ	pfam domains	PF00595	122	2	17795	47	RIMS2,RIMS1
4.132e-02	-3.19	EIF2B2 (eukaryotic translation initiation factor 2B subunit beta)	protein interactions	8892	128	2	19454	49	SYT1,PCDH9
4.132e-02	-3.19	SYT2 (synaptotagmin 2)	protein interactions	127833	128	2	19454	49	NRXN1,SYT1
4.132e-02	-3.19	FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1)	protein interactions	10160	128	2	19454	49	PTPRG,ANK2
4.145e-02	-3.18	IRK	pfam domains	PF01007	16	1	17795	47	KCNJ3
4.145e-02	-3.18	IRK_C	pfam domains	PF17655	16	1	17795	47	KCNJ3
4.147e-02	-3.18	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	45	PTPRG
4.147e-02	-3.18	ephrin receptor activity	molecular function	GO:0005003	17	1	18094	45	EPHA5
4.147e-02	-3.18	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	45	PTPRG
4.147e-02	-3.18	ligand-gated sodium channel activity	molecular function	GO:0015280	17	1	18094	45	GRIK2
4.152e-02	-3.18	K_chnl_inward-rec_Kir_cyto	interpro domains	IPR013518	16	1	18521	49	KCNJ3
4.152e-02	-3.18	IRK_C	interpro domains	IPR041647	16	1	18521	49	KCNJ3
4.152e-02	-3.18	K_chnl_inward-rec_Kir	interpro domains	IPR016449	16	1	18521	49	KCNJ3
4.152e-02	-3.18	Kir_TM	interpro domains	IPR040445	16	1	18521	49	KCNJ3
4.164e-02	-3.18	Nifedipine Action Pathway	SMPDB pathways	SMP0000379	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Amlodipine Action Pathway	SMPDB pathways	SMP0000376	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Metoprolol Action Pathway	SMPDB pathways	SMP0000302	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Levobunolol Action Pathway	SMPDB pathways	SMP0000666	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Fosphenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000326	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Isoprenaline Action Pathway	SMPDB pathways	SMP0000663	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Quinidine Action Pathway	SMPDB pathways	SMP0000323	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Esmolol Action Pathway	SMPDB pathways	SMP0000301	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Practolol Action Pathway	SMPDB pathways	SMP0000669	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Sotalol Action Pathway	SMPDB pathways	SMP0000660	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Mexiletine Action Pathway	SMPDB pathways	SMP0000329	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Bopindolol Action Pathway	SMPDB pathways	SMP0000657	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Dobutamine Action Pathway	SMPDB pathways	SMP0000662	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Epinephrine Action Pathway	SMPDB pathways	SMP0000661	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Carteolol Action Pathway	SMPDB pathways	SMP0000658	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Acebutolol Action Pathway	SMPDB pathways	SMP0000296	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Nadolol Action Pathway	SMPDB pathways	SMP0000303	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Bisoprolol Action Pathway	SMPDB pathways	SMP0000300	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Diltiazem Action Pathway	SMPDB pathways	SMP0000359	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Betaxolol Action Pathway	SMPDB pathways	SMP0000299	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Pindolol Action Pathway	SMPDB pathways	SMP0000306	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Timolol Action Pathway	SMPDB pathways	SMP0000659	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Disopyramide Action Pathway	SMPDB pathways	SMP0000325	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Atenolol Action Pathway	SMPDB pathways	SMP0000298	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Amiodarone Action Pathway	SMPDB pathways	SMP0000665	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Nimodipine Action Pathway	SMPDB pathways	SMP0000380	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Propranolol Action Pathway	SMPDB pathways	SMP0000307	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Verapamil Action Pathway	SMPDB pathways	SMP0000375	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Procainamide (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000324	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Arbutamine Action Pathway	SMPDB pathways	SMP0000664	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Alprenolol Action Pathway	SMPDB pathways	SMP0000297	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Tocainide Action Pathway	SMPDB pathways	SMP0000330	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Felodipine Action Pathway	SMPDB pathways	SMP0000377	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Penbutolol Action Pathway	SMPDB pathways	SMP0000305	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Ibutilide Action Pathway	SMPDB pathways	SMP0000332	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Nitrendipine Action Pathway	SMPDB pathways	SMP0000382	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Bevantolol Action Pathway	SMPDB pathways	SMP0000668	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Nebivolol Action Pathway	SMPDB pathways	SMP0000366	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Flecainide Action Pathway	SMPDB pathways	SMP0000331	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Oxprenolol Action Pathway	SMPDB pathways	SMP0000304	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Muscle/Heart Contraction	SMPDB pathways	SMP0000588	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Isradipine Action Pathway	SMPDB pathways	SMP0000378	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Metipranolol Action Pathway	SMPDB pathways	SMP0000667	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Bupranolol Action Pathway	SMPDB pathways	SMP0000670	57	1	1369	1	KCNJ3
4.164e-02	-3.18	Nisoldipine Action Pathway	SMPDB pathways	SMP0000381	57	1	1369	1	KCNJ3
4.176e-02	-3.18	ephrin a2 ectodomain	gene3d domains	2.60.40.1770	14	1	14470	44	EPHA5
4.179e-02	-3.18	cytoplasmic region	cellular component	GO:0099568	307	3	19108	48	RIMS1,RIMS2,GRIK2
4.190e-02	-3.17	EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)	protein interactions	8890	129	2	19454	49	PCDH9,SYT1
4.198e-02	-3.17	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	49	NRXN3
4.198e-02	-3.17	CNTN2 (contactin 2)	protein interactions	6900	17	1	19454	49	CNTNAP2
4.198e-02	-3.17	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	49	APOE
4.198e-02	-3.17	EPB42 (erythrocyte membrane protein band 4.2)	protein interactions	2038	17	1	19454	49	ANK2
4.198e-02	-3.17	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	49	DTNA
4.226e-02	-3.16	human chr2p25.3	chromosome location	human chr2p25.3	23	1	26134	49	MYT1L
4.237e-02	-3.16	Carvedilol Action Pathway	SMPDB pathways	SMP0000367	58	1	1369	1	KCNJ3
4.237e-02	-3.16	Labetalol Action Pathway	SMPDB pathways	SMP0000368	58	1	1369	1	KCNJ3
4.264e-02	-3.15	protein kinase activator activity	molecular function	GO:0030295	132	2	18094	45	NRG1,NRG3
4.277e-02	-3.15	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	3	19454	49	DTNA,NRXN1,NRXN3
4.310e-02	-3.14	Lidocaine (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000328	59	1	1369	1	KCNJ3
4.359e-02	-3.13	ectopic germ cell programmed cell death	biological process	GO:0035234	18	1	18204	45	UNC5C
4.359e-02	-3.13	spinal cord patterning	biological process	GO:0021511	18	1	18204	45	RELN
4.359e-02	-3.13	positive regulation of dendritic spine morphogenesis	biological process	GO:0061003	18	1	18204	45	RELN
4.359e-02	-3.13	positive regulation of neuron migration	biological process	GO:2001224	18	1	18204	45	RELN
4.359e-02	-3.13	negative regulation of platelet activation	biological process	GO:0010544	18	1	18204	45	APOE
4.359e-02	-3.13	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	45	CST3
4.359e-02	-3.13	secretory granule localization	biological process	GO:0032252	18	1	18204	45	CADPS2
4.385e-02	-3.13	racemase and epimerase activity	molecular function	GO:0016854	18	1	18094	45	GLCE
4.385e-02	-3.13	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	45	APOE
4.385e-02	-3.13	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	1	18094	45	SLC1A3
4.398e-02	-3.12	ZZ	pfam domains	PF00569	17	1	17795	47	DTNA
4.398e-02	-3.12	Carb_anhydrase	pfam domains	PF00194	17	1	17795	47	PTPRG
4.398e-02	-3.12	Cystatin	pfam domains	PF00031	17	1	17795	47	CST3
4.399e-02	-3.12	Lipid digestion, mobilization, and transport	REACTOME pathways	R-HSA-73923	115	2	10285	30	RELN,APOE
4.406e-02	-3.12	Synaptotagmin	interpro domains	IPR001565	17	1	18521	49	SYT1
4.406e-02	-3.12	Cystatin_dom	interpro domains	IPR000010	17	1	18521	49	CST3
4.406e-02	-3.12	CA_dom_sf	interpro domains	IPR036398	17	1	18521	49	PTPRG
4.406e-02	-3.12	CA_dom	interpro domains	IPR001148	17	1	18521	49	PTPRG
4.406e-02	-3.12	human chr3p24.3	chromosome location	human chr3p24.3	24	1	26134	49	ZNF385D
4.427e-02	-3.12	PTPRS (protein tyrosine phosphatase receptor type S)	protein interactions	5802	133	2	19454	49	LRRTM4,GPC6
4.428e-02	-3.12	costamere	cellular component	GO:0043034	18	1	19108	48	ANK2
4.440e-02	-3.11	Ccdc77 (coiled-coil domain containing 77)	protein interactions	67200	18	1	19454	49	CACNA2D1
4.440e-02	-3.11	RELN (reelin)	protein interactions	5649	18	1	19454	49	RELN
4.440e-02	-3.11	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	49	APOE
4.440e-02	-3.11	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	2	18094	45	GRIK2,KCNJ3
4.487e-02	-3.10	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	49	ANK2,SYT1
4.487e-02	-3.10	ARL4C (ADP ribosylation factor like GTPase 4C)	protein interactions	10123	134	2	19454	49	PCDH9,UNC5C
4.500e-02	-3.10	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	2	18094	45	TRPM3,CACNA2D1
4.501e-02	-3.10	EPH_LBD	prosite domains	PS51550	14	1	12186	40	EPHA5
4.501e-02	-3.10	RECEPTOR_TYR_KIN_V_2	prosite domains	PS00791	14	1	12186	40	EPHA5
4.501e-02	-3.10	RECEPTOR_TYR_KIN_V_1	prosite domains	PS00790	14	1	12186	40	EPHA5
4.510e-02	-3.10	cell recognition	biological process	GO:0008037	137	2	18204	45	CNTNAP2,CNTN4
4.511e-02	-3.10	positive regulation of cellular process	biological process	GO:0048522	5719	20	18204	45	RIMS2,LINGO2,RIMS1,NPAS3,NFIA,NRXN1,CACNA2D1,GRID2,ANK2,SYT1,RELN,CADPS2,GRIK2,SLC1A3,UNC5C,CNTNAP2,GLCE,NRG1,APOE,ST18
4.523e-02	-3.10	postsynaptic density	cellular component	GO:0014069	317	3	19108	48	GRID2,GRIK2,GRIA4
4.556e-02	-3.09	LGALS1 (galectin 1)	protein interactions	3956	317	3	19454	49	LINGO2,PTPRG,PCDH9
4.585e-02	-3.08	ErbB receptor signaling network	Pathway Interaction DB	erbb_network_pathway	13	1	2226	8	NRG3
4.596e-02	-3.08	DWA	smart domains	SM00523	12	1	9717	38	NFIA
4.596e-02	-3.08	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	biological process	GO:1902514	19	1	18204	45	CACNA2D1
4.596e-02	-3.08	presynapse assembly	biological process	GO:0099054	19	1	18204	45	CNTN5
4.596e-02	-3.08	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	45	APOE
4.596e-02	-3.08	regulation of amyloid-beta clearance	biological process	GO:1900221	19	1	18204	45	APOE
4.608e-02	-3.08	NIBAN2 (niban apoptosis regulator 2)	protein interactions	64855	136	2	19454	49	EPHA5,PTPRG
4.619e-02	-3.07	protease binding	molecular function	GO:0002020	138	2	18094	45	CNTNAP2,CST3
4.622e-02	-3.07	signal transduction	biological process	GO:0007165	4637	17	18204	45	PTPRG,UNC5C,RELN,GRIK2,APOE,GRIA4,NRG1,ST18,CHN2,NFIA,ZNF385B,RIMS2,EPHA5,DTNA,ANK2,GRID2,NRG3
4.623e-02	-3.07	syntaxin-1 binding	molecular function	GO:0017075	19	1	18094	45	SYT1
4.629e-02	-3.07	positive regulation of cation transmembrane transport	biological process	GO:1904064	139	2	18204	45	CACNA2D1,ANK2
4.629e-02	-3.07	TSP1REPEAT	prints domains	PR01705	13	1	5227	19	UNC5C
4.681e-02	-3.06	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	49	NRXN1
4.681e-02	-3.06	RAB26 (RAB26, member RAS oncogene family)	protein interactions	25837	19	1	19454	49	RIMS1
4.681e-02	-3.06	Cep76 (centrosomal protein 76)	protein interactions	225659	19	1	19454	49	CACNA2D1
4.681e-02	-3.06	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	49	DTNA
4.681e-02	-3.06	OSM (oncostatin M)	protein interactions	5008	19	1	19454	49	TRPM3
4.681e-02	-3.06	CACNA1B (calcium voltage-gated channel subunit alpha1 B)	protein interactions	774	19	1	19454	49	RIMS1
4.681e-02	-3.06	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	49	DTNA
4.681e-02	-3.06	CCL19 (C-C motif chemokine ligand 19)	protein interactions	6363	19	1	19454	49	CACNA2D1
4.696e-02	-3.06	Cadherins	gene3d domains	2.60.40.60	114	2	14470	44	CDH18,PCDH9
4.706e-02	-3.06	clathrin-coated vesicle membrane	cellular component	GO:0030665	138	2	19108	48	SYT1,APOE
4.740e-02	-3.05	kinase activator activity	molecular function	GO:0019209	140	2	18094	45	NRG3,NRG1
4.742e-02	-3.05	central_nervous_system-diencephalon-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-diencephalon-glioma-astrocytoma_Grade_I	17	1	16828	48	CNTNAP2
4.742e-02	-3.05	diencephalon	COSMIC cancer mutations	diencephalon	17	1	16828	48	CNTNAP2
4.758e-02	-3.05	G protein-activated inward rectifier potassium channel 1	gene3d domains	2.60.40.1400	16	1	14470	44	KCNJ3
4.765e-02	-3.04	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	49	DTNA
4.792e-02	-3.04	PTPRA (protein tyrosine phosphatase receptor type A)	protein interactions	5786	139	2	19454	49	UNC5C,PTPRG
4.802e-02	-3.04	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	48	16828	48	MYT1L,GRIA4,TLL1,FSTL5,EBF1,GRIK2,ANK2,CNTN5,CNTNAP2,LINGO2,CACNA2D1,EPHA5,PTPRG,GLCE,GPC6,CNTN4,NRXN3,DTNA,UNC5C,LSAMP,TRPM3,NRG3,RIMS2,KCNJ3,ZNF385D,STXBP5L,CST3,LRRTM4,RALYL,RUNX1T1,NRG1,SLC35F3,CHN2,SLC1A3,NRXN1,NPAS3,ST18,NFIA,PCDH9,ZNF385B,APOE,RIMS1,RELN,SYT1,GRID2,CDH18,CADPS2,KIF21A
4.832e-02	-3.03	positive regulation of potassium ion transmembrane transporter activity	biological process	GO:1901018	20	1	18204	45	ANK2
4.832e-02	-3.03	axonal fasciculation	biological process	GO:0007413	20	1	18204	45	CNTN4
4.832e-02	-3.03	membrane repolarization during cardiac muscle cell action potential	biological process	GO:0086013	20	1	18204	45	KCNJ3
4.832e-02	-3.03	nitric oxide mediated signal transduction	biological process	GO:0007263	20	1	18204	45	APOE
4.832e-02	-3.03	aspartate transmembrane transport	biological process	GO:0015810	20	1	18204	45	SLC1A3
4.832e-02	-3.03	cardiac muscle cell membrane repolarization	biological process	GO:0099622	20	1	18204	45	KCNJ3
4.832e-02	-3.03	neuron projection fasciculation	biological process	GO:0106030	20	1	18204	45	CNTN4
4.848e-02	-3.03	Trafficking of GluR2-containing AMPA receptors	REACTOME pathways	R-HSA-416993	17	1	10285	30	GRIA4
4.848e-02	-3.03	Unblocking of NMDA receptor, glutamate binding and activation	REACTOME pathways	R-HSA-438066	17	1	10285	30	GRIA4
4.853e-02	-3.03	EFNB2 (ephrin B2)	protein interactions	1948	140	2	19454	49	EPHA5,RELN
4.900e-02	-3.02	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	4	16828	48	GRIA4,PCDH9,LSAMP,CNTN5
4.900e-02	-3.02	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	4	16828	48	CNTN5,GRIA4,PCDH9,LSAMP
4.903e-02	-3.02	PDZ_6	pfam domains	PF17820	19	1	17795	47	RIMS2
4.903e-02	-3.02	PAS	pfam domains	PF00989	19	1	17795	47	NPAS3
4.903e-02	-3.02	zf-MYND	pfam domains	PF01753	19	1	17795	47	RUNX1T1
4.908e-02	-3.01	triglyceride-rich plasma lipoprotein particle	cellular component	GO:0034385	20	1	19108	48	APOE
4.908e-02	-3.01	very-low-density lipoprotein particle	cellular component	GO:0034361	20	1	19108	48	APOE
4.911e-02	-3.01	PDZ_6	interpro domains	IPR041489	19	1	18521	49	RIMS2
4.911e-02	-3.01	PAS_fold	interpro domains	IPR013767	19	1	18521	49	NPAS3
4.911e-02	-3.01	Znf_ZZ	interpro domains	IPR000433	19	1	18521	49	DTNA
4.911e-02	-3.01	Znf_ZZ_sf	interpro domains	IPR043145	19	1	18521	49	DTNA
4.921e-02	-3.01	NTN1 (netrin 1)	protein interactions	9423	20	1	19454	49	UNC5C
4.921e-02	-3.01	MLC1 (modulator of VRAC current 1)	protein interactions	23209	20	1	19454	49	DTNA
4.921e-02	-3.01	KCNJ5 (potassium inwardly rectifying channel subfamily J member 5)	protein interactions	3762	20	1	19454	49	KCNJ3
4.921e-02	-3.01	SAXO5 (stabilizer of axonemal microtubules 5)	protein interactions	374877	20	1	19454	49	CADPS2
4.921e-02	-3.01	GALNT5 (polypeptide N-acetylgalactosaminyltransferase 5)	protein interactions	11227	20	1	19454	49	NRG1
4.921e-02	-3.01	ADRA1D (adrenoceptor alpha 1D)	protein interactions	146	20	1	19454	49	DTNA
4.921e-02	-3.01	CCDC197 (coiled-coil domain containing 197)	protein interactions	256369	20	1	19454	49	RUNX1T1
4.923e-02	-3.01	voltage-gated monoatomic cation channel activity	molecular function	GO:0022843	143	2	18094	45	CACNA2D1,KCNJ3
4.943e-02	-3.01	human chr2p12	chromosome location	human chr2p12	27	1	26134	49	LRRTM4
4.961e-02	-3.00	CADHERIN_1	prosite domains	PS00232	109	2	12186	40	CDH18,PCDH9
4.965e-02	-3.00	protein transport	biological process	GO:0015031	1086	6	18204	45	STXBP5L,CADPS2,ANK2,RIMS2,RIMS1,APOE