C2C module introduction

A strength of SPEED is the sequence-centric integrations of a large collection of different species. C2C module, on the other hand, provides detailed information on potential cell communication mediated by ligands and corresponding receptors using scRNA-seq data. C2C module provides potential cell interaction networks and signaling pathways between different cell types of 46 species. Each species is accompanied by a series of viualization of cell interaction networks and a series of heatmaps of signalling pathways between certain cell types, as well as a table summarizing every ligand-receptor interaction and signaling pathway between any two cell types.

  • SP_ID : SP088
  • Rds : SP088_Ara_ararauna
  • Literature : Pan_C2_SP088_Ara_ararauna
  • Cluster : C2
  • Classification : Birds
  • CommonName : Blue-and-yellow macaw
  • LatinName : Ara ararauna
  • Tissue : PBMC
  • Reference : ——
  • Journal : Clin Transl Med
  • Title : Screening of cell-virus, cell-cell, gene-gene cross-talks among kingdoms of life at single cell resolution
  • Institution : BGI-Shenzhen, Shenzhen 518083, China
  • View cell atlas in ShinyCell
View C2C


View cell interaction network between different cell types
View signalling pathway between different cell types
source target ligand receptor prob pval interaction_name interaction_name_2 pathway_name annotation evidence
1 C6 C0 MIF CD74_CXCR4 0.0396418907429735 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
2 C7 C0 MIF CD74_CXCR4 0.0389191418211053 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
3 C10 C0 MIF CD74_CXCR4 0.0414582696463711 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
4 C6 C5 MIF CD74_CXCR4 0.042172445882256 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
5 C7 C5 MIF CD74_CXCR4 0.0414055491893918 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
6 C10 C5 MIF CD74_CXCR4 0.0440994496568149 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
7 C6 C6 MIF CD74_CXCR4 0.0755729877806249 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
8 C7 C6 MIF CD74_CXCR4 0.074245790593315 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
9 C10 C6 MIF CD74_CXCR4 0.078900458348164 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
10 C6 C7 MIF CD74_CXCR4 0.0356526547250957 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
11 C7 C7 MIF CD74_CXCR4 0.0349999866688255 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
12 C10 C7 MIF CD74_CXCR4 0.0372933461599976 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
13 C6 C10 MIF CD74_CXCR4 0.0325049524730341 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
14 C7 C10 MIF CD74_CXCR4 0.0319080005835924 0 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
15 C10 C10 MIF CD74_CXCR4 0.0340058984946685 0.01 MIF_CD74_CXCR4 MIF - (CD74+CXCR4) MIF Secreted Signaling PMID: 29637711; PMID: 24760155
16 C6 C0 MIF CD74_CD44 0.0654309151904319 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
17 C7 C0 MIF CD74_CD44 0.0642694479382844 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
18 C10 C0 MIF CD74_CD44 0.0683448460968285 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
19 C6 C2 MIF CD74_CD44 0.0371649285991337 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
20 C7 C2 MIF CD74_CD44 0.0364856238254911 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
21 C10 C2 MIF CD74_CD44 0.0388724077605255 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
22 C6 C4 MIF CD74_CD44 0.021919219177191 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
23 C7 C4 MIF CD74_CD44 0.0215123511228106 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
24 C10 C4 MIF CD74_CD44 0.0229429506753973 0.02 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
25 C6 C5 MIF CD74_CD44 0.0647625679246961 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
26 C7 C5 MIF CD74_CD44 0.0636121570133616 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
27 C10 C5 MIF CD74_CD44 0.0676488888480164 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
28 C6 C6 MIF CD74_CD44 0.0411195769956662 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
29 C7 C6 MIF CD74_CD44 0.0403710195092415 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
30 C10 C6 MIF CD74_CD44 0.0430006313878215 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
31 C6 C7 MIF CD74_CD44 0.0787728504291379 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
32 C7 C7 MIF CD74_CD44 0.0773941626571431 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
33 C10 C7 MIF CD74_CD44 0.0822286783394691 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
34 C6 C9 MIF CD74_CD44 0.0271164955342277 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
35 C7 C9 MIF CD74_CD44 0.0266157800430155 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
36 C10 C9 MIF CD74_CD44 0.0283759222289071 0.01 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
37 C6 C10 MIF CD74_CD44 0.072998076856274 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
38 C7 C10 MIF CD74_CD44 0.0717125917685056 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
39 C10 C10 MIF CD74_CD44 0.0762215222879075 0 MIF_CD74_CD44 MIF - (CD74+CD44) MIF Secreted Signaling PMID: 29637711; PMID: 26175090
40 C6 C10 MIF ACKR3 0.00951211145923757 0 MIF_ACKR3 MIF - ACKR3 MIF Secreted Signaling PMID: 26175090
41 C7 C10 MIF ACKR3 0.00933334845732055 0 MIF_ACKR3 MIF - ACKR3 MIF Secreted Signaling PMID: 26175090
42 C10 C10 MIF ACKR3 0.00996227439914993 0 MIF_ACKR3 MIF - ACKR3 MIF Secreted Signaling PMID: 26175090
43 C7 C0 IL18 IL18R1_IL18RAP 0.0157591138163409 0 IL18_IL18R1_IL18RAP IL18 - (IL18R1+IL18RAP) IL1 Secreted Signaling KEGG: hsa04060
44 C10 C0 IL18 IL18R1_IL18RAP 0.0174465865266481 0 IL18_IL18R1_IL18RAP IL18 - (IL18R1+IL18RAP) IL1 Secreted Signaling KEGG: hsa04060
45 C7 C4 CSF3 CSF3R 0.101250979116981 0 CSF3_CSF3R CSF3 - CSF3R CSF3 Secreted Signaling KEGG: hsa04060
46 C10 C4 CSF3 CSF3R 0.169433569585177 0 CSF3_CSF3R CSF3 - CSF3R CSF3 Secreted Signaling KEGG: hsa04060
47 C7 C7 CSF3 CSF3R 0.101629424887683 0 CSF3_CSF3R CSF3 - CSF3R CSF3 Secreted Signaling KEGG: hsa04060
48 C10 C7 CSF3 CSF3R 0.170018651533932 0 CSF3_CSF3R CSF3 - CSF3R CSF3 Secreted Signaling KEGG: hsa04060
49 C7 C10 CSF3 CSF3R 0.099973953647787 0 CSF3_CSF3R CSF3 - CSF3R CSF3 Secreted Signaling KEGG: hsa04060
50 C10 C10 CSF3 CSF3R 0.167456820815795 0 CSF3_CSF3R CSF3 - CSF3R CSF3 Secreted Signaling KEGG: hsa04060
51 C7 C0 FN1 ITGA4_ITGB1 0.207773055275706 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
52 C10 C0 FN1 ITGA4_ITGB1 0.198833241967933 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
53 C7 C7 FN1 ITGA4_ITGB1 0.267265697551184 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
54 C10 C7 FN1 ITGA4_ITGB1 0.256595194642042 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
55 C7 C9 FN1 ITGA4_ITGB1 0.115861492866044 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
56 C10 C9 FN1 ITGA4_ITGB1 0.110325614886202 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
57 C7 C10 FN1 ITGA4_ITGB1 0.260104158985213 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
58 C10 C10 FN1 ITGA4_ITGB1 0.249622172598488 0 FN1_ITGA4_ITGB1 FN1 - (ITGA4+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
59 C7 C7 FN1 ITGAV_ITGB1 0.271315466258602 0 FN1_ITGAV_ITGB1 FN1 - (ITGAV+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
60 C10 C7 FN1 ITGAV_ITGB1 0.260540768704612 0 FN1_ITGAV_ITGB1 FN1 - (ITGAV+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
61 C7 C10 FN1 ITGAV_ITGB1 0.258590908263871 0 FN1_ITGAV_ITGB1 FN1 - (ITGAV+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
62 C10 C10 FN1 ITGAV_ITGB1 0.248149451986715 0 FN1_ITGAV_ITGB1 FN1 - (ITGAV+ITGB1) FN1 ECM-Receptor KEGG: hsa04512
63 C7 C10 FN1 ITGAV_ITGB3 0.229401837181578 0 FN1_ITGAV_ITGB3 FN1 - (ITGAV+ITGB3) FN1 ECM-Receptor KEGG: hsa04512
64 C10 C10 FN1 ITGAV_ITGB3 0.21978958990886 0 FN1_ITGAV_ITGB3 FN1 - (ITGAV+ITGB3) FN1 ECM-Receptor KEGG: hsa04512
65 C7 C3 FN1 ITGA2B_ITGB3 0.290257317630689 0 FN1_ITGA2B_ITGB3 FN1 - (ITGA2B+ITGB3) FN1 ECM-Receptor KEGG: hsa04512
66 C10 C3 FN1 ITGA2B_ITGB3 0.279018421751615 0 FN1_ITGA2B_ITGB3 FN1 - (ITGA2B+ITGB3) FN1 ECM-Receptor KEGG: hsa04512
67 C7 C10 FN1 ITGA2B_ITGB3 0.287332825517081 0 FN1_ITGA2B_ITGB3 FN1 - (ITGA2B+ITGB3) FN1 ECM-Receptor KEGG: hsa04512
68 C10 C10 FN1 ITGA2B_ITGB3 0.276163106175095 0 FN1_ITGA2B_ITGB3 FN1 - (ITGA2B+ITGB3) FN1 ECM-Receptor KEGG: hsa04512
69 C7 C0 FN1 CD44 0.300742024286225 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
70 C10 C0 FN1 CD44 0.289262613917582 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
71 C7 C2 FN1 CD44 0.135544296778773 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
72 C10 C2 FN1 CD44 0.129205405908291 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
73 C7 C4 FN1 CD44 0.14997399607391 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
74 C10 C4 FN1 CD44 0.143071969700377 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
75 C7 C5 FN1 CD44 0.295685273472606 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
76 C10 C5 FN1 CD44 0.284320399193979 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
77 C7 C6 FN1 CD44 0.123594194086663 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
78 C10 C6 FN1 CD44 0.117738047722086 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
79 C7 C7 FN1 CD44 0.384554229831571 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
80 C10 C7 FN1 CD44 0.371575658344977 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
81 C7 C9 FN1 CD44 0.107834034962274 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
82 C10 C9 FN1 CD44 0.102637184412206 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
83 C7 C10 FN1 CD44 0.362660445064685 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
84 C10 C10 FN1 CD44 0.350000568565777 0 FN1_CD44 FN1 - CD44 FN1 ECM-Receptor KEGG: hsa04512
85 C7 C0 FN1 SDC4 0.134720267303304 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
86 C10 C0 FN1 SDC4 0.128414188556472 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
87 C7 C4 FN1 SDC4 0.36352601942377 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
88 C10 C4 FN1 SDC4 0.350852560800594 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
89 C7 C5 FN1 SDC4 0.125123645578697 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
90 C10 C5 FN1 SDC4 0.119204887521249 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
91 C7 C7 FN1 SDC4 0.387144243935403 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
92 C10 C7 FN1 SDC4 0.374131398446137 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
93 C7 C9 FN1 SDC4 0.104349506760013 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
94 C10 C9 FN1 SDC4 0.0993018949045391 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
95 C7 C10 FN1 SDC4 0.386303699552838 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
96 C10 C10 FN1 SDC4 0.373301897519892 0 FN1_SDC4 FN1 - SDC4 FN1 ECM-Receptor KEGG: hsa04512
97 C7 C0 APP CD74 0.207763164221623 0 APP_CD74 APP - CD74 APP Cell-Cell Contact PMID: 19849849
98 C9 C0 APP CD74 0.116445900108008 0 APP_CD74 APP - CD74 APP Cell-Cell Contact PMID: 19849849
99 C10 C0 APP CD74 0.157047501715421 0 APP_CD74 APP - CD74 APP Cell-Cell Contact PMID: 19849849
100 C7 C1 APP CD74 0.0650342644567005 0 APP_CD74 APP - CD74 APP Cell-Cell Contact PMID: 19849849
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