Hematopoietic stem and progenitor cells

Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow and are responsible for lifelong blood cell production (hematopoiesis). Hematopoietic stem cells (HSCs) have long-term self-renewal and multipotent differentiation capacity. Progenitor cells (like CMPs, CLPs) are more restricted in potential but highly proliferative. Together, they give rise to all lineages of blood and immune cells.