Stellate cells

In the liver, hepatic stellate cells (HSCs) reside in the space of Disse. In their quiescent state, they store vitamin A. Upon liver injury, they activate, proliferate, and transform into myofibroblast-like cells that produce large amounts of extracellular matrix, driving liver fibrosis and cirrhosis. Pancreatic stellate cells play a similar fibrogenic role in pancreatitis and pancreatic cancer.