Common lymphoid progenitors

Common lymphoid progenitors (CLPs) are bone marrow-derived progenitor cells committed exclusively to the lymphoid lineage. They arise from hematopoietic stem cells and give rise to all lymphocytes: B cells, T cells, Natural Killer (NK) cells, and some dendritic cell subsets (lymphoid DCs). The CLP represents the critical branch point in hematopoiesis where the lymphoid pathway is specified.