Purkinje cells

Purkinje cells are large, GABAergic inhibitory neurons that form a single layer in the cerebellar cortex. They are the sole output neurons of the cerebellar cortex, projecting to the deep cerebellar nuclei. They receive massive excitatory input from parallel fibers (granule cell axons) and powerful, instructive input from a single climbing fiber. Their complex dendritic tree integrates these signals to fine-tune motor coordination, balance, and motor learning.