scGeneBank is an intuitive platform that combines single-cell transcriptomes from 136 species with 597 curated gene sets across 28 biological categories, enabling cross-species, organ- and cell-type specific analysis. Its eight interactive module, GeneSets, Species, EvoScreening, OrganScreening, StemAtlas, AgingScope, PathoView and DeathMap, facilitate exploration of evolutionary patterns, stemness, aging, disease and cell-death signatures with detailed gene-level annotations.