TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-HSA-1251985 Nuclear signaling by ERBB4 6.00697451260302e-05 -9.72000425206059 25 3 0.09375 32 10285 2066,2670,10718 ERBB4,GFAP,NRG3 R-HSA-111885 Opioid Signalling 0.000130964582280085 -8.9405836355923 85 4 0.125 32 10285 5142,114,10768,23236 PDE4B,ADCY8,AHCYL1,PLCB1 R-HSA-1236394 Signaling by ERBB4 0.000310282622651184 -8.07802698984676 43 3 0.09375 32 10285 10718,2670,2066 NRG3,GFAP,ERBB4 R-HSA-372790 Signaling by GPCR 0.000310528598961901 -8.07723455467476 1299 12 0.375 32 10285 1608,6000,114,2066,10718,388,10768,1910,8997,5142,23236,9628 DGKG,RGS7,ADCY8,ERBB4,NRG3,RHOB,AHCYL1,EDNRB,KALRN,PDE4B,PLCB1,RGS6 R-HSA-112043 PLC beta mediated events 0.000404255075931487 -7.8134645031691 47 3 0.09375 32 10285 10768,23236,114 AHCYL1,PLCB1,ADCY8 R-HSA-1250342 PI3K events in ERBB4 signaling 0.000415525633570316 -7.7859662522617 10 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-112040 G-protein mediated events 0.000430295911000396 -7.7510374208365 48 3 0.09375 32 10285 114,23236,10768 ADCY8,PLCB1,AHCYL1 R-HSA-162582 Signal Transduction 0.000522459327170517 -7.55696341989106 2547 17 0.53125 32 10285 57522,1272,8997,2262,5142,1910,388,10768,10718,6000,27327,2066,23236,9628,114,1608,2670 SRGAP1,CNTN1,KALRN,GPC5,PDE4B,EDNRB,RHOB,AHCYL1,NRG3,RGS7,TNRC6A,ERBB4,PLCB1,RGS6,ADCY8,DGKG,GFAP R-HSA-8847993 ERBB2 Activates PTK6 Signaling 0.000716056522889909 -7.24175145153576 13 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-1250347 SHC1 events in ERBB4 signaling 0.000833777526826371 -7.08954394559564 14 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-6785631 ERBB2 Regulates Cell Motility 0.000960183698203525 -6.94838593951257 15 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-1963642 PI3K events in ERBB2 signaling 0.00109522325809639 -6.81679704782364 16 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-1963640 GRB2 events in ERBB2 signaling 0.00109522325809639 -6.81679704782364 16 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-2024096 HS-GAG degradation 0.00189812503548056 -6.26688870347184 21 2 0.0625 32 10285 2262,60495 GPC5,HPSE2 R-HSA-422356 Regulation of insulin secretion 0.00191061082554778 -6.26033228409826 80 3 0.09375 32 10285 10768,23236,114 AHCYL1,PLCB1,ADCY8 R-HSA-1250196 SHC1 events in ERBB2 signaling 0.00208388987852953 -6.17351899788375 22 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.00215346733459029 -6.14067602210603 443 6 0.1875 32 10285 23236,8997,1910,10718,2066,1608 PLCB1,KALRN,EDNRB,NRG3,ERBB4,DGKG R-HSA-388396 GPCR downstream signaling 0.00222868981736707 -6.10634139201541 974 9 0.28125 32 10285 1608,6000,114,388,1910,8997,5142,23236,9628 DGKG,RGS7,ADCY8,RHOB,EDNRB,KALRN,PDE4B,PLCB1,RGS6 R-HSA-416476 G alpha (q) signalling events 0.00281163159080949 -5.87399032684234 192 4 0.125 32 10285 1910,23236,8997,1608 EDNRB,PLCB1,KALRN,DGKG R-HSA-166520 Signalling by NGF 0.00312139471858867 -5.76947535185806 477 6 0.1875 32 10285 8997,114,27327,2066,10718,10768 KALRN,ADCY8,TNRC6A,ERBB4,NRG3,AHCYL1 R-HSA-8863795 Downregulation of ERBB2 signaling 0.00386380727272193 -5.55610224153575 30 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-112316 Neuronal System 0.00413821319628281 -5.48749117940966 349 5 0.15625 32 10285 23236,114,3751,6538,9378 PLCB1,ADCY8,KCND2,SLC6A11,NRXN1 R-HSA-186763 Downstream signal transduction 0.00429179120017503 -5.45105110400493 352 5 0.15625 32 10285 10718,10768,27327,2066,114 NRG3,AHCYL1,TNRC6A,ERBB4,ADCY8 R-HSA-2424491 DAP12 signaling 0.00450289453760114 -5.40303485841195 356 5 0.15625 32 10285 2066,27327,114,10768,10718 ERBB4,TNRC6A,ADCY8,AHCYL1,NRG3 R-HSA-163685 Integration of energy metabolism 0.00483251956279574 -5.33238729871704 111 3 0.09375 32 10285 114,10768,23236 ADCY8,AHCYL1,PLCB1 R-HSA-1489509 DAG and IP3 signaling 0.00494452209774667 -5.30947496210724 34 2 0.0625 32 10285 114,10768 ADCY8,AHCYL1 R-HSA-177929 Signaling by EGFR 0.00494734631501181 -5.30890394413085 364 5 0.15625 32 10285 114,2066,27327,10718,10768 ADCY8,ERBB4,TNRC6A,NRG3,AHCYL1 R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.00527702212766366 -5.24439333133949 229 4 0.125 32 10285 27327,2066,10768,10718 TNRC6A,ERBB4,AHCYL1,NRG3 R-HSA-2172127 DAP12 interactions 0.00536130884414617 -5.2285471463676 371 5 0.15625 32 10285 114,2066,27327,10718,10768 ADCY8,ERBB4,TNRC6A,NRG3,AHCYL1 R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.00542240335616589 -5.21721613816695 372 5 0.15625 32 10285 27327,2066,5602,10718,10768 TNRC6A,ERBB4,MAPK10,NRG3,AHCYL1 R-HSA-167021 PLC-gamma1 signalling 0.0055312149288538 -5.19734778977434 36 2 0.0625 32 10285 114,10768 ADCY8,AHCYL1 R-HSA-212718 EGFR interacts with phospholipase C-gamma 0.0055312149288538 -5.19734778977434 36 2 0.0625 32 10285 10768,114 AHCYL1,ADCY8 R-HSA-186797 Signaling by PDGF 0.00567176196692382 -5.17225545697216 376 5 0.15625 32 10285 114,27327,2066,10718,10768 ADCY8,TNRC6A,ERBB4,NRG3,AHCYL1 R-HSA-422475 Axon guidance 0.00621573067425893 -5.08067199467739 549 6 0.1875 32 10285 2066,388,10718,8997,1272,57522 ERBB4,RHOB,NRG3,KALRN,CNTN1,SRGAP1 R-HSA-187037 NGF signalling via TRKA from the plasma membrane 0.00639955149061185 -5.0515273706641 387 5 0.15625 32 10285 114,2066,27327,10768,10718 ADCY8,ERBB4,TNRC6A,AHCYL1,NRG3 R-HSA-1257604 PIP3 activates AKT signaling 0.00672196442991312 -5.00237484128604 125 3 0.09375 32 10285 10718,2066,27327 NRG3,ERBB4,TNRC6A R-HSA-198203 PI3K/AKT activation 0.00717643190906793 -4.93695296803966 128 3 0.09375 32 10285 10718,27327,2066 NRG3,TNRC6A,ERBB4 R-HSA-180292 GAB1 signalosome 0.00717643190906793 -4.93695296803966 128 3 0.09375 32 10285 27327,2066,10718 TNRC6A,ERBB4,NRG3 R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.00764881692154777 -4.87320429388143 131 3 0.09375 32 10285 10718,2066,27327 NRG3,ERBB4,TNRC6A R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 0.00782145005674995 -4.85088531236288 43 2 0.0625 32 10285 6000,9628 RGS7,RGS6 R-HSA-3000171 Non-integrin membrane-ECM interactions 0.00854192864699934 -4.7627684597938 45 2 0.0625 32 10285 3371,9378 TNC,NRXN1 R-HSA-194840 Rho GTPase cycle 0.00953684487114418 -4.6525925745191 142 3 0.09375 32 10285 388,57522,8997 RHOB,SRGAP1,KALRN R-HSA-5576891 Cardiac conduction 0.00953684487114418 -4.6525925745191 142 3 0.09375 32 10285 10768,6263,3751 AHCYL1,RYR3,KCND2 R-HSA-1227986 Signaling by ERBB2 0.0108742221571746 -4.52136023034253 51 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-5683057 MAPK family signaling cascades 0.0119551074258596 -4.42659669226031 290 4 0.125 32 10285 10718,8997,27327,2066 NRG3,KALRN,TNRC6A,ERBB4 R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 0.0121342608643842 -4.41172235106248 54 2 0.0625 32 10285 2262,60495 GPC5,HPSE2 R-HSA-888593 Reuptake of GABA 0.0123891455272221 -4.39093455043096 4 1 0.03125 32 10285 6538 SLC6A11 R-HSA-5578775 Ion homeostasis 0.0130082524773649 -4.34217131697353 56 2 0.0625 32 10285 10768,6263 AHCYL1,RYR3 R-HSA-4086398 Ca2+ pathway 0.0153095825163495 -4.17927633837477 61 2 0.0625 32 10285 23236,27327 PLCB1,TNRC6A R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.0172675037551387 -4.05892893953259 65 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-8848021 Signaling by PTK6 0.0182844907518715 -4.00170207836357 67 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-447043 Neurofascin interactions 0.0215832912912218 -3.83583581496955 7 1 0.03125 32 10285 1272 CNTN1 R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase 0.0215832912912218 -3.83583581496955 7 1 0.03125 32 10285 114 ADCY8 R-HSA-426496 Post-transcriptional silencing by small RNAs 0.0215832912912218 -3.83583581496955 7 1 0.03125 32 10285 27327 TNRC6A R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels 0.0215832912912218 -3.83583581496955 7 1 0.03125 32 10285 3751 KCND2 R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.0228327333806986 -3.77956009802514 197 3 0.09375 32 10285 27327,2066,10718 TNRC6A,ERBB4,NRG3 R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 0.0246295390704036 -3.70380878117813 8 1 0.03125 32 10285 23236 PLCB1 R-HSA-1253288 Downregulation of ERBB4 signaling 0.0246295390704036 -3.70380878117813 8 1 0.03125 32 10285 2066 ERBB4 R-HSA-5362798 Release of Hh-Np from the secreting cell 0.0246295390704036 -3.70380878117813 8 1 0.03125 32 10285 2262 GPC5 R-HSA-400451 Free fatty acids regulate insulin secretion 0.0246295390704036 -3.70380878117813 8 1 0.03125 32 10285 23236 PLCB1 R-HSA-397014 Muscle contraction 0.0249997529516903 -3.68888933609515 204 3 0.09375 32 10285 3751,6263,10768 KCND2,RYR3,AHCYL1 R-HSA-428543 Inactivation of Cdc42 and Rac 0.0276665980127613 -3.58752944132319 9 1 0.03125 32 10285 57522 SRGAP1 R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins 0.0276665980127613 -3.58752944132319 9 1 0.03125 32 10285 388 RHOB R-HSA-112315 Transmission across Chemical Synapses 0.0293116918420489 -3.52976880357622 217 3 0.09375 32 10285 114,6538,23236 ADCY8,SLC6A11,PLCB1 R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.0297710972871699 -3.51421724581041 87 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-416482 G alpha (12/13) signalling events 0.0304050937308631 -3.49314512766977 88 2 0.0625 32 10285 388,8997 RHOB,KALRN R-HSA-170660 Adenylate cyclase activating pathway 0.0306944949440151 -3.48367195825287 10 1 0.03125 32 10285 114 ADCY8 R-HSA-450341 Activation of the AP-1 family of transcription factors 0.0306944949440151 -3.48367195825287 10 1 0.03125 32 10285 5602 MAPK10 R-HSA-399997 Acetylcholine regulates insulin secretion 0.0306944949440151 -3.48367195825287 10 1 0.03125 32 10285 23236 PLCB1 R-HSA-5687128 MAPK6/MAPK4 signaling 0.0316892510617294 -3.45177773882682 90 2 0.0625 32 10285 8997,27327 KALRN,TNRC6A R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.0316892510617294 -3.45177773882682 90 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-71288 Creatine metabolism 0.0337132566135048 -3.38986414765342 11 1 0.03125 32 10285 6538 SLC6A11 R-HSA-199418 Negative regulation of the PI3K/AKT network 0.0343211807033788 -3.37199260217503 94 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-3656237 Defective EXT2 causes exostoses 2 0.0367229096985265 -3.30435447621323 12 1 0.03125 32 10285 2262 GPC5 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 0.0367229096985265 -3.30435447621323 12 1 0.03125 32 10285 2262 GPC5 R-HSA-390466 Chaperonin-mediated protein folding 0.0377273394712305 -3.27737026243442 99 2 0.0625 32 10285 6000,9628 RGS7,RGS6 R-HSA-418594 G alpha (i) signalling events 0.0386489993317491 -3.25323439479489 242 3 0.09375 32 10285 6000,114,9628 RGS7,ADCY8,RGS6 R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.0397234807967155 -3.2258128102934 13 1 0.03125 32 10285 10768 AHCYL1 R-HSA-2672351 Stimuli-sensing channels 0.0412584510557436 -3.18789931310664 104 2 0.0625 32 10285 80036,6263 TRPM3,RYR3 R-HSA-391251 Protein folding 0.0419792774341666 -3.17057917688245 105 2 0.0625 32 10285 6000,9628 RGS7,RGS6 R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.0427048901672599 -3.15344184148149 106 2 0.0625 32 10285 6538,6563 SLC6A11,SLC14A1 R-HSA-1483213 Synthesis of PE 0.0427149964321149 -3.15320521590625 14 1 0.03125 32 10285 23175 LPIN1 R-HSA-5218921 VEGFR2 mediated cell proliferation 0.0453371729123556 -3.09362798890467 258 3 0.09375 32 10285 2066,10718,10768 ERBB4,NRG3,AHCYL1 R-HSA-170670 Adenylate cyclase inhibitory pathway 0.0456974830572342 -3.08571205793272 15 1 0.03125 32 10285 114 ADCY8 R-HSA-975577 N-Glycan antennae elongation 0.0456974830572342 -3.08571205793272 15 1 0.03125 32 10285 25834 MGAT4C R-HSA-997269 Inhibition of adenylate cyclase pathway 0.0456974830572342 -3.08571205793272 15 1 0.03125 32 10285 114 ADCY8 R-HSA-4419969 Depolymerisation of the Nuclear Lamina 0.0456974830572342 -3.08571205793272 15 1 0.03125 32 10285 23175 LPIN1 R-HSA-157118 Signaling by NOTCH 0.0471571487798919 -3.0542696635823 112 2 0.0625 32 10285 27327,1272 TNRC6A,CNTN1 R-HSA-2871796 FCERI mediated MAPK activation 0.0484350376573577 -3.02753180862174 265 3 0.09375 32 10285 2066,5602,10718 ERBB4,MAPK10,NRG3 R-HSA-163615 PKA activation 0.0486709670417284 -3.02267258597464 16 1 0.03125 32 10285 114 ADCY8 R-HSA-111931 PKA-mediated phosphorylation of CREB 0.0516354746935388 -2.96354634864957 17 1 0.03125 32 10285 114 ADCY8 R-HSA-5625900 RHO GTPases activate CIT 0.0516354746935388 -2.96354634864957 17 1 0.03125 32 10285 388 RHOB R-HSA-5627117 RHO GTPases Activate ROCKs 0.0516354746935388 -2.96354634864957 17 1 0.03125 32 10285 388 RHOB R-HSA-164378 PKA activation in glucagon signalling 0.0516354746935388 -2.96354634864957 17 1 0.03125 32 10285 114 ADCY8 R-HSA-382551 Transmembrane transport of small molecules 0.0560161276720372 -2.88211563556582 677 5 0.15625 32 10285 80036,114,6538,6263,6563 TRPM3,ADCY8,SLC6A11,RYR3,SLC14A1 R-HSA-1630316 Glycosaminoglycan metabolism 0.0565456016827311 -2.87270785693854 124 2 0.0625 32 10285 60495,2262 HPSE2,GPC5 R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 0.0575376658111058 -2.85531548805095 19 1 0.03125 32 10285 5602 MAPK10 R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 0.0575376658111058 -2.85531548805095 19 1 0.03125 32 10285 2262 GPC5 R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.0575376658111058 -2.85531548805095 19 1 0.03125 32 10285 6538 SLC6A11 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 0.0575376658111058 -2.85531548805095 19 1 0.03125 32 10285 2262 GPC5 R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters 0.0575376658111058 -2.85531548805095 19 1 0.03125 32 10285 6538 SLC6A11 R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 0.0575376658111058 -2.85531548805095 19 1 0.03125 32 10285 2262 GPC5 R-HSA-2559580 Oxidative Stress Induced Senescence 0.0581700045224908 -2.84438544331337 126 2 0.0625 32 10285 27327,5602 TNRC6A,MAPK10 R-HSA-418217 G beta:gamma signalling through PLC beta 0.0604754015110534 -2.80551858321824 20 1 0.03125 32 10285 23236 PLCB1 R-HSA-3000170 Syndecan interactions 0.0604754015110534 -2.80551858321824 20 1 0.03125 32 10285 3371 TNC R-HSA-1474244 Extracellular matrix organization 0.0633772240664574 -2.75865072393575 296 3 0.09375 32 10285 9378,3371,2202 NRXN1,TNC,EFEMP1 R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.0634042653354377 -2.75822414321773 21 1 0.03125 32 10285 1272 CNTN1 R-HSA-500657 Presynaptic function of Kainate receptors 0.0634042653354377 -2.75822414321773 21 1 0.03125 32 10285 23236 PLCB1 R-HSA-5358351 Signaling by Hedgehog 0.0682512920072161 -2.68455891458759 138 2 0.0625 32 10285 114,2262 ADCY8,GPC5 R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.0721378844941515 -2.62917592894156 24 1 0.03125 32 10285 388 RHOB R-HSA-3295583 TRP channels 0.0750315193953614 -2.58984699512492 25 1 0.03125 32 10285 80036 TRPM3 R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 0.0752731832752791 -2.58663133940868 146 2 0.0625 32 10285 23236,114 PLCB1,ADCY8 R-HSA-418555 G alpha (s) signalling events 0.0752731832752791 -2.58663133940868 146 2 0.0625 32 10285 5142,114 PDE4B,ADCY8 R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.0779164113409515 -2.55211867639439 26 1 0.03125 32 10285 2262 GPC5 R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 0.0779164113409515 -2.55211867639439 26 1 0.03125 32 10285 2262 GPC5 R-HSA-2029485 Role of phospholipids in phagocytosis 0.0779164113409515 -2.55211867639439 26 1 0.03125 32 10285 10768 AHCYL1 R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi 0.0779164113409515 -2.55211867639439 26 1 0.03125 32 10285 25834 MGAT4C R-HSA-3858494 Beta-catenin independent WNT signaling 0.0779647335432178 -2.55149868859728 149 2 0.0625 32 10285 27327,23236 TNRC6A,PLCB1 R-HSA-114508 Effects of PIP2 hydrolysis 0.0807925859034172 -2.51587007628624 27 1 0.03125 32 10285 1608 DGKG R-HSA-400685 Sema4D in semaphorin signaling 0.0807925859034172 -2.51587007628624 27 1 0.03125 32 10285 388 RHOB R-HSA-180024 DARPP-32 events 0.0807925859034172 -2.51587007628624 27 1 0.03125 32 10285 5142 PDE4B R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.0819549674116419 -2.50158536047811 330 3 0.09375 32 10285 2066,10718,10768 ERBB4,NRG3,AHCYL1 R-HSA-1483191 Synthesis of PC 0.0836600685751663 -2.48099349327961 28 1 0.03125 32 10285 23175 LPIN1 R-HSA-111933 Calmodulin induced events 0.0836600685751663 -2.48099349327961 28 1 0.03125 32 10285 114 ADCY8 R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.0836600685751663 -2.48099349327961 28 1 0.03125 32 10285 23236 PLCB1 R-HSA-111997 CaM pathway 0.0836600685751663 -2.48099349327961 28 1 0.03125 32 10285 114 ADCY8 R-HSA-1433557 Signaling by SCF-KIT 0.0860485412776073 -2.45284370850073 337 3 0.09375 32 10285 27327,2066,10718 TNRC6A,ERBB4,NRG3 R-HSA-194138 Signaling by VEGF 0.0866405502826766 -2.4459873249398 338 3 0.09375 32 10285 2066,10768,10718 ERBB4,AHCYL1,NRG3 R-HSA-111996 Ca-dependent events 0.0893690598669384 -2.41498074320399 30 1 0.03125 32 10285 114 ADCY8 R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.0893690598669384 -2.41498074320399 30 1 0.03125 32 10285 27327 TNRC6A R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.0893690598669384 -2.41498074320399 30 1 0.03125 32 10285 1272 CNTN1 R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.0893690598669384 -2.41498074320399 30 1 0.03125 32 10285 10768 AHCYL1 R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.0922106191148623 -2.38367998027011 31 1 0.03125 32 10285 5602 MAPK10 R-HSA-418990 Adherens junctions interactions 0.0922106191148623 -2.38367998027011 31 1 0.03125 32 10285 253559 CADM2 R-HSA-2022928 HS-GAG biosynthesis 0.0922106191148623 -2.38367998027011 31 1 0.03125 32 10285 2262 GPC5 R-HSA-2129379 Molecules associated with elastic fibres 0.0922106191148623 -2.38367998027011 31 1 0.03125 32 10285 2202 EFEMP1 R-HSA-376176 Signaling by Robo receptor 0.0950435877279201 -2.35341967441784 32 1 0.03125 32 10285 57522 SRGAP1 R-HSA-451326 Activation of Kainate Receptors upon glutamate binding 0.0950435877279201 -2.35341967441784 32 1 0.03125 32 10285 23236 PLCB1 R-HSA-2559585 Oncogene Induced Senescence 0.0950435877279201 -2.35341967441784 32 1 0.03125 32 10285 27327 TNRC6A R-HSA-1980145 Signaling by NOTCH2 0.0978679908499735 -2.32413574051804 33 1 0.03125 32 10285 1272 CNTN1 R-HSA-4085001 Sialic acid metabolism 0.0978679908499735 -2.32413574051804 33 1 0.03125 32 10285 80896 NPL R-HSA-163359 Glucagon signaling in metabolic regulation 0.0978679908499735 -2.32413574051804 33 1 0.03125 32 10285 114 ADCY8 R-HSA-438064 Post NMDA receptor activation events 0.10908044860994 -2.21566960834415 37 1 0.03125 32 10285 114 ADCY8 R-HSA-1266738 Developmental Biology 0.110704292084074 -2.20089266780531 1075 6 0.1875 32 10285 1272,57522,10718,388,8997,2066 CNTN1,SRGAP1,NRG3,RHOB,KALRN,ERBB4 R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 0.114635932841785 -2.16599397374523 39 1 0.03125 32 10285 10768 AHCYL1 R-HSA-991365 Activation of GABAB receptors 0.117401075352029 -2.14215921190242 40 1 0.03125 32 10285 114 ADCY8 R-HSA-977444 GABA B receptor activation 0.117401075352029 -2.14215921190242 40 1 0.03125 32 10285 114 ADCY8 R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events 0.120157850907958 -2.1189489763796 41 1 0.03125 32 10285 114 ADCY8 R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.122906284017519 -2.09633313257394 42 1 0.03125 32 10285 114 ADCY8 R-HSA-1566948 Elastic fibre formation 0.122906284017519 -2.09633313257394 42 1 0.03125 32 10285 2202 EFEMP1 R-HSA-3928662 EPHB-mediated forward signaling 0.122906284017519 -2.09633313257394 42 1 0.03125 32 10285 8997 KALRN R-HSA-2559583 Cellular Senescence 0.123666807330622 -2.09016436759908 196 2 0.0625 32 10285 27327,5602 TNRC6A,MAPK10 R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 0.125646399111676 -2.07428367348774 43 1 0.03125 32 10285 114 ADCY8 R-HSA-1296072 Voltage gated Potassium channels 0.128378220555944 -2.05277452395213 44 1 0.03125 32 10285 3751 KCND2 R-HSA-975634 Retinoid metabolism and transport 0.128378220555944 -2.05277452395213 44 1 0.03125 32 10285 2262 GPC5 R-HSA-1912422 Pre-NOTCH Expression and Processing 0.136524165598078 -1.99125364267783 47 1 0.03125 32 10285 27327 TNRC6A R-HSA-1483249 Inositol phosphate metabolism 0.136524165598078 -1.99125364267783 47 1 0.03125 32 10285 23236 PLCB1 R-HSA-983712 Ion channel transport 0.137275461026568 -1.98576570740676 209 2 0.0625 32 10285 80036,6263 TRPM3,RYR3 R-HSA-418597 G alpha (z) signalling events 0.139223054705304 -1.97167792191284 48 1 0.03125 32 10285 114 ADCY8 R-HSA-194315 Signaling by Rho GTPases 0.14510910534028 -1.93026936888798 426 3 0.09375 32 10285 57522,388,8997 SRGAP1,RHOB,KALRN R-HSA-397795 G-protein beta:gamma signalling 0.147270780621694 -1.91548234164228 51 1 0.03125 32 10285 23236 PLCB1 R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 0.147270780621694 -1.91548234164228 51 1 0.03125 32 10285 2262 GPC5 R-HSA-112310 Neurotransmitter Release Cycle 0.147270780621694 -1.91548234164228 51 1 0.03125 32 10285 6538 SLC6A11 R-HSA-2980766 Nuclear Envelope Breakdown 0.149937121740231 -1.89753926116836 52 1 0.03125 32 10285 23175 LPIN1 R-HSA-445717 Aquaporin-mediated transport 0.149937121740231 -1.89753926116836 52 1 0.03125 32 10285 114 ADCY8 R-HSA-6806667 Metabolism of fat-soluble vitamins 0.152595385412158 -1.87996540035207 53 1 0.03125 32 10285 2262 GPC5 R-HSA-114604 GPVI-mediated activation cascade 0.155245595304473 -1.86274693020084 54 1 0.03125 32 10285 388 RHOB R-HSA-977443 GABA receptor activation 0.160521948185941 -1.82932459693927 56 1 0.03125 32 10285 114 ADCY8 R-HSA-3000178 ECM proteoglycans 0.163148138197818 -1.81309666760573 57 1 0.03125 32 10285 3371 TNC R-HSA-6794361 Interactions of neurexins and neuroligins at synapses 0.165766368506073 -1.79717590060759 58 1 0.03125 32 10285 9378 NRXN1 R-HSA-193648 NRAGE signals death through JNK 0.170979043327558 -1.7662142836298 60 1 0.03125 32 10285 8997 KALRN R-HSA-421270 Cell-cell junction organization 0.173573534340938 -1.75115394033099 61 1 0.03125 32 10285 253559 CADM2 R-HSA-180336 SHC1 events in EGFR signaling 0.176521258042546 -1.73431396769396 245 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-112412 SOS-mediated signalling 0.176521258042546 -1.73431396769396 245 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-179812 GRB2 events in EGFR signaling 0.176521258042546 -1.73431396769396 245 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-5673001 RAF/MAP kinase cascade 0.176521258042546 -1.73431396769396 245 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.178738939332428 -1.72182897718307 63 1 0.03125 32 10285 80896 NPL R-HSA-170984 ARMS-mediated activation 0.180995705778528 -1.70928197297826 249 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-187706 Signalling to p38 via RIT and RIN 0.180995705778528 -1.70928197297826 249 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-450294 MAP kinase activation in TLR cascade 0.181309899414681 -1.70754756031441 64 1 0.03125 32 10285 5602 MAPK10 R-HSA-170968 Frs2-mediated activation 0.182117248888457 -1.70310457466712 250 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-5684996 MAPK1/MAPK3 signaling 0.183239929828326 -1.69695889291321 251 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-169893 Prolonged ERK activation events 0.18436373143436 -1.69084467139996 252 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-2586552 Signaling by Leptin 0.185488636634118 -1.6847616568481 253 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-912526 Interleukin receptor SHC signaling 0.187741689965467 -1.67268825048673 255 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-167044 Signalling to RAS 0.188869804392425 -1.666697366948 256 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-5358346 Hedgehog ligand biogenesis 0.188976085252336 -1.6661348049849 67 1 0.03125 32 10285 2262 GPC5 R-HSA-373755 Semaphorin interactions 0.191515991817425 -1.65278396566306 68 1 0.03125 32 10285 388 RHOB R-HSA-216083 Integrin cell surface interactions 0.191515991817425 -1.65278396566306 68 1 0.03125 32 10285 3371 TNC R-HSA-451927 Interleukin-2 signaling 0.195659671839872 -1.63137849715005 262 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-187687 Signalling to ERKs 0.196794693363131 -1.62559425934577 263 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-6794362 Protein-protein interactions at synapses 0.201598779260101 -1.60147579806069 72 1 0.03125 32 10285 9378 NRXN1 R-HSA-168249 Innate Immune System 0.203254132706863 -1.59329819763983 1285 6 0.1875 32 10285 114,27327,2066,10718,10768,5602 ADCY8,TNRC6A,ERBB4,NRG3,AHCYL1,MAPK10 R-HSA-1980143 Signaling by NOTCH1 0.204100379093278 -1.58914335177816 73 1 0.03125 32 10285 1272 CNTN1 R-HSA-8853659 RET signaling 0.204764756701219 -1.58589348704518 270 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling 0.205906706835562 -1.58033209221244 271 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.211559703955465 -1.55324803212612 76 1 0.03125 32 10285 8997 KALRN R-HSA-375165 NCAM signaling for neurite out-growth 0.211628087227519 -1.55292485043669 276 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 0.216494913999375 -1.53018822373528 78 1 0.03125 32 10285 80896 NPL R-HSA-76002 Platelet activation, signaling and aggregation 0.218517336610892 -1.5208899238371 282 2 0.0625 32 10285 1608,388 DGKG,RHOB R-HSA-446203 Asparagine N-linked glycosylation 0.220818959046276 -1.51041210301959 284 2 0.0625 32 10285 80896,25834 NPL,MGAT4C R-HSA-425407 SLC-mediated transmembrane transport 0.224275874705318 -1.49487840139806 287 2 0.0625 32 10285 6538,6563 SLC6A11,SLC14A1 R-HSA-5628897 TP53 Regulates Metabolic Genes 0.226275713098856 -1.48600105380395 82 1 0.03125 32 10285 27327 TNRC6A R-HSA-75109 Triglyceride Biosynthesis 0.226275713098856 -1.48600105380395 82 1 0.03125 32 10285 23175 LPIN1 R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.231121652589057 -1.46481107249901 84 1 0.03125 32 10285 5602 MAPK10 R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.231121652589057 -1.46481107249901 84 1 0.03125 32 10285 5602 MAPK10 R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.231121652589057 -1.46481107249901 84 1 0.03125 32 10285 5602 MAPK10 R-HSA-112399 IRS-mediated signalling 0.23236094696479 -1.45946331044525 294 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-3781865 Diseases of glycosylation 0.23353358349255 -1.45442938569467 85 1 0.03125 32 10285 2262 GPC5 R-HSA-71387 Metabolism of carbohydrates 0.234675337258759 -1.44955226362894 296 2 0.0625 32 10285 2262,60495 GPC5,HPSE2 R-HSA-74751 Insulin receptor signalling cascade 0.235833192529517 -1.44463053518102 297 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.235938184014607 -1.44418544040824 86 1 0.03125 32 10285 10768 AHCYL1 R-HSA-2428924 IGF1R signaling cascade 0.236991469988879 -1.43973113010282 298 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-2428928 IRS-related events triggered by IGF1R 0.236991469988879 -1.43973113010282 298 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.238150156309787 -1.43485389538534 299 2 0.0625 32 10285 10718,2066 NRG3,ERBB4 R-HSA-351202 Metabolism of polyamines 0.238335475722727 -1.43407603595024 87 1 0.03125 32 10285 6538 SLC6A11 R-HSA-446728 Cell junction organization 0.240725480113748 -1.42409808140873 88 1 0.03125 32 10285 253559 CADM2 R-HSA-1280218 Adaptive Immune System 0.242099861711028 -1.41840498624428 810 4 0.125 32 10285 10718,10768,2066,27327 NRG3,AHCYL1,ERBB4,TNRC6A R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.247851983484315 -1.39492355178657 91 1 0.03125 32 10285 5602 MAPK10 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.250213052393737 -1.38544251446934 92 1 0.03125 32 10285 22854 NTNG1 R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.252566940593716 -1.37607895414026 93 1 0.03125 32 10285 5602 MAPK10 R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.252566940593716 -1.37607895414026 93 1 0.03125 32 10285 5602 MAPK10 R-HSA-5625740 RHO GTPases activate PKNs 0.252566940593716 -1.37607895414026 93 1 0.03125 32 10285 388 RHOB R-HSA-2682334 EPH-Ephrin signaling 0.257253259271952 -1.35769423468079 95 1 0.03125 32 10285 8997 KALRN R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.257253259271952 -1.35769423468079 95 1 0.03125 32 10285 5602 MAPK10 R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.257253259271952 -1.35769423468079 95 1 0.03125 32 10285 5602 MAPK10 R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.257253259271952 -1.35769423468079 95 1 0.03125 32 10285 5602 MAPK10 R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane 0.257253259271952 -1.35769423468079 95 1 0.03125 32 10285 5602 MAPK10 R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.261911107921518 -1.33975011553275 97 1 0.03125 32 10285 5602 MAPK10 R-HSA-193704 p75 NTR receptor-mediated signalling 0.261911107921518 -1.33975011553275 97 1 0.03125 32 10285 8997 KALRN R-HSA-74752 Signaling by Insulin receptor 0.264883205501043 -1.328466284106 322 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling 0.266540653930485 -1.32222849942888 99 1 0.03125 32 10285 5602 MAPK10 R-HSA-166166 MyD88-independent TLR3/TLR4 cascade 0.266540653930485 -1.32222849942888 99 1 0.03125 32 10285 5602 MAPK10 R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.266540653930485 -1.32222849942888 99 1 0.03125 32 10285 5602 MAPK10 R-HSA-1296071 Potassium Channels 0.268844865503738 -1.31362077390496 100 1 0.03125 32 10285 3751 KCND2 R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.271142063761799 -1.30511237493477 101 1 0.03125 32 10285 10768 AHCYL1 R-HSA-5610787 Hedgehog 'off' state 0.271142063761799 -1.30511237493477 101 1 0.03125 32 10285 114 ADCY8 R-HSA-2187338 Visual phototransduction 0.271142063761799 -1.30511237493477 101 1 0.03125 32 10285 2262 GPC5 R-HSA-373760 L1CAM interactions 0.271142063761799 -1.30511237493477 101 1 0.03125 32 10285 1272 CNTN1 R-HSA-195721 Signaling by Wnt 0.281193681183517 -1.26871159019598 336 2 0.0625 32 10285 23236,27327 PLCB1,TNRC6A R-HSA-5578749 Transcriptional regulation by small RNAs 0.282523576473711 -1.26399327533383 106 1 0.03125 32 10285 27327 TNRC6A R-HSA-166054 Activated TLR4 signalling 0.30257790503276 -1.1954164973699 115 1 0.03125 32 10285 5602 MAPK10 R-HSA-5663220 RHO GTPases Activate Formins 0.306960105577046 -1.18103748909951 117 1 0.03125 32 10285 388 RHOB R-HSA-5663202 Diseases of signal transduction 0.319554980176273 -1.14082593804008 369 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.32635210493076 -1.11977840400365 126 1 0.03125 32 10285 5602 MAPK10 R-HSA-1483206 Glycerophospholipid biosynthesis 0.332698500522642 -1.10051860296323 129 1 0.03125 32 10285 23175 LPIN1 R-HSA-1500931 Cell-Cell communication 0.341070324689352 -1.0756665922007 133 1 0.03125 32 10285 253559 CADM2 R-HSA-211000 Gene Silencing by RNA 0.349340359980305 -1.05170858852411 137 1 0.03125 32 10285 27327 TNRC6A R-HSA-68875 Mitotic Prophase 0.357509804553404 -1.02859249189993 141 1 0.03125 32 10285 23175 LPIN1 R-HSA-5621481 C-type lectin receptors (CLRs) 0.363571588385929 -1.01177905948455 144 1 0.03125 32 10285 10768 AHCYL1 R-HSA-168898 Toll-Like Receptors Cascades 0.381426371766013 -0.963837443565368 153 1 0.03125 32 10285 5602 MAPK10 R-HSA-948021 Transport to the Golgi and subsequent modification 0.402590608590857 -0.909835092946543 164 1 0.03125 32 10285 25834 MGAT4C R-HSA-2262752 Cellular responses to stress 0.412577549727949 -0.885331091536581 451 2 0.0625 32 10285 5602,27327 MAPK10,TNRC6A R-HSA-196854 Metabolism of vitamins and cofactors 0.421220835039015 -0.86459803404112 174 1 0.03125 32 10285 2262 GPC5 R-HSA-375276 Peptide ligand-binding receptors 0.446360388250548 -0.806628607850185 188 1 0.03125 32 10285 1910 EDNRB R-HSA-1483257 Phospholipid metabolism 0.478792353137266 -0.736488276317112 207 1 0.03125 32 10285 23175 LPIN1 R-HSA-449147 Signaling by Interleukins 0.491395267150464 -0.710506450299878 525 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-1643685 Disease 0.506317275754388 -0.680591779011495 858 3 0.09375 32 10285 2066,2262,10718 ERBB4,GPC5,NRG3 R-HSA-1430728 Metabolism 0.520098269442325 -0.653737505564298 2158 7 0.21875 32 10285 2262,60495,6538,114,23175,10768,23236 GPC5,HPSE2,SLC6A11,ADCY8,LPIN1,AHCYL1,PLCB1 R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism 0.549874114775105 -0.598065909180237 253 1 0.03125 32 10285 23175 LPIN1 R-HSA-392499 Metabolism of proteins 0.581892798020823 -0.541469044057346 1619 5 0.15625 32 10285 9628,6000,25834,22854,80896 RGS6,RGS7,MGAT4C,NTNG1,NPL R-HSA-109582 Hemostasis 0.593647478147091 -0.521469606926035 632 2 0.0625 32 10285 1608,388 DGKG,RHOB R-HSA-195258 RHO GTPase Effectors 0.60524137916765 -0.502127926689364 294 1 0.03125 32 10285 388 RHOB R-HSA-68886 M Phase 0.622589716912604 -0.473867537473692 308 1 0.03125 32 10285 23175 LPIN1 R-HSA-597592 Post-translational protein modification 0.637430747264017 -0.450309639593129 1034 3 0.09375 32 10285 22854,25834,80896 NTNG1,MGAT4C,NPL R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.639198458045102 -0.44754029685291 322 1 0.03125 32 10285 1910 EDNRB R-HSA-168256 Immune System 0.662267118496726 -0.412086302169359 2101 6 0.1875 32 10285 10718,10768,5602,114,27327,2066 NRG3,AHCYL1,MAPK10,ADCY8,TNRC6A,ERBB4 R-HSA-71291 Metabolism of amino acids and derivatives 0.681818264449926 -0.382992131062889 361 1 0.03125 32 10285 6538 SLC6A11 R-HSA-3700989 Transcriptional Regulation by TP53 0.687926253579329 -0.374073636358934 367 1 0.03125 32 10285 27327 TNRC6A R-HSA-1280215 Cytokine Signaling in Immune system 0.692970106268217 -0.366768417420748 756 2 0.0625 32 10285 2066,10718 ERBB4,NRG3 R-HSA-500792 GPCR ligand binding 0.763932955219765 -0.269275248614259 453 1 0.03125 32 10285 1910 EDNRB R-HSA-69278 Cell Cycle, Mitotic 0.806622081613149 -0.214900020754498 514 1 0.03125 32 10285 23175 LPIN1 R-HSA-1640170 Cell Cycle 0.864126326961379 -0.146036309105124 621 1 0.03125 32 10285 23175 LPIN1 R-HSA-556833 Metabolism of lipids and lipoproteins 0.92858407305878 -0.0740943551062093 813 1 0.03125 32 10285 23175 LPIN1 R-HSA-212436 Generic Transcription Pathway 0.940136226585331 -0.0617304923189628 865 1 0.03125 32 10285 27327 TNRC6A R-HSA-74160 Gene Expression 0.998061940050378 -0.00193994041783927 1821 1 0.03125 32 10285 27327 TNRC6A R-HSA-190370 FGFR1b ligand binding and activation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-428808 Na+-dependent glucose transporters 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-3000484 Scavenging by Class F Receptors 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-3323169 Defects in biotin (Btn) metabolism 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-111957 Cam-PDE 1 activation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-2187335 The retinoid cycle in cones (daylight vision) 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-1482798 Acyl chain remodeling of CL 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5676934 Protein repair 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-8857538 PTK6 promotes HIF1A stabilization 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-1566977 Fibronectin matrix formation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5660668 CLEC7A/inflammasome pathway 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-388479 Vasopressin-like receptors 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-6787639 GDP-fucose biosynthesis 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-390247 Beta-oxidation of very long chain fatty acids 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-211916 Vitamins 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-6798163 Choline catabolism 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-6806942 MET Receptor Activation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-8851907 MET activates PI3K/AKT signaling 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-947581 Molybdenum cofactor biosynthesis 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-193144 Estrogen biosynthesis 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-187015 Activation of TRKA receptors 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-173623 Classical antibody-mediated complement activation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-442717 CREB phosphorylation through the activation of CaMKK 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-1237112 Methionine salvage pathway 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-176417 Phosphorylation of Emi1 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-446199 Synthesis of Dolichyl-phosphate 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5624138 Trafficking of myristoylated proteins to the cilium 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-205025 NADE modulates death signalling 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-3065679 SUMO is proteolytically processed 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5626978 TNFR1-mediated ceramide production 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5336415 Uptake and function of diphtheria toxin 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-2142700 Synthesis of Lipoxins (LX) 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-6793080 rRNA modification in the mitochondrion 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-6799990 Metal sequestration by antimicrobial proteins 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-177135 Conjugation of benzoate with glycine 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-189483 Heme degradation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-444257 RSK activation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-193993 Mineralocorticoid biosynthesis 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5690714 CD22 mediated BCR regulation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5579029 Metabolic disorders of biological oxidation enzymes 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5339717 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-500753 Pyrimidine biosynthesis 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-166662 Lectin pathway of complement activation 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-8849470 PTK6 Regulates Cell Cycle 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.999999999958433 -4.15666944637395e-11 6 0 0 32 10285 R-HSA-1592389 Activation of Matrix Metalloproteinases 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-196071 Metabolism of steroid hormones 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-68962 Activation of the pre-replicative complex 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-69190 DNA strand elongation 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-70171 Glycolysis 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-70263 Gluconeogenesis 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-73863 RNA Polymerase I Transcription Termination 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-168638 NOD1/2 Signaling Pathway 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-399721 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-399719 Trafficking of AMPA receptors 0.999999999963629 -3.63715132096001e-11 32 0 0 32 10285 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-936837 Ion transport by P-type ATPases 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-381070 IRE1alpha activates chaperones 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.999999999966825 -3.31748985743783e-11 58 0 0 32 10285 R-HSA-3214815 HDACs deacetylate histones 0.99999999996691 -3.30897811268463e-11 94 0 0 32 10285 R-HSA-877300 Interferon gamma signaling 0.99999999996691 -3.30897811268463e-11 94 0 0 32 10285 R-HSA-5368287 Mitochondrial translation 0.99999999996691 -3.30897811268463e-11 94 0 0 32 10285 R-HSA-69473 G2/M DNA damage checkpoint 0.999999999968751 -3.12487062784088e-11 95 0 0 32 10285 R-HSA-2408557 Selenocysteine synthesis 0.999999999968751 -3.12487062784088e-11 95 0 0 32 10285 R-HSA-211976 Endogenous sterols 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-437239 Recycling pathway of L1 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-1266695 Interleukin-7 signaling 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-354192 Integrin alphaIIb beta3 signaling 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-5576893 Phase 2 - plateau phase 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-264876 Insulin processing 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-174800 Chylomicron-mediated lipid transport 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-6803529 FGFR2 alternative splicing 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-2022854 Keratan sulfate biosynthesis 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-70268 Pyruvate metabolism 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-5621480 Dectin-2 family 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-1368082 RORA activates gene expression 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-190828 Gap junction trafficking 0.999999999968865 -3.11353069542982e-11 28 0 0 32 10285 R-HSA-1632852 Macroautophagy 0.999999999969171 -3.08288747054946e-11 67 0 0 32 10285 R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 0.999999999969171 -3.08288747054946e-11 67 0 0 32 10285 R-HSA-4608870 Asymmetric localization of PCP proteins 0.999999999969171 -3.08288747054946e-11 67 0 0 32 10285 R-HSA-69615 G1/S DNA Damage Checkpoints 0.999999999969171 -3.08288747054946e-11 67 0 0 32 10285 R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.999999999969171 -3.08288747054946e-11 67 0 0 32 10285 R-HSA-109704 PI3K Cascade 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-3214858 RMTs methylate histone arginines 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-2871837 FCERI mediated NF-kB activation 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-1221632 Meiotic synapsis 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-6807878 COPI-mediated anterograde transport 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-1483255 PI Metabolism 0.999999999969351 -3.06487084531795e-11 79 0 0 32 10285 R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-549127 Organic cation transport 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-8851805 MET activates RAS signaling 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-69416 Dimerization of procaspase-8 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-1980150 Signaling by NOTCH4 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-1839122 Signaling by activated point mutants of FGFR1 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-376172 DSCAM interactions 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-2485179 Activation of the phototransduction cascade 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-1059683 Interleukin-6 signaling 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-446107 Type I hemidesmosome assembly 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-2470946 Cohesin Loading onto Chromatin 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-8875555 MET activates RAP1 and RAC1 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-3371378 Regulation by c-FLIP 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5655291 Signaling by FGFR4 in disease 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-68689 CDC6 association with the ORC:origin complex 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5660526 Response to metal ions 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-3296469 Defects in cobalamin (B12) metabolism 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-71182 Phenylalanine and tyrosine catabolism 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5625970 RHO GTPases activate KTN1 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-2022923 Dermatan sulfate biosynthesis 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-196780 Biotin transport and metabolism 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-193048 Androgen biosynthesis 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5218900 CASP8 activity is inhibited 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-75072 mRNA Editing 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-1980148 Signaling by NOTCH3 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-174490 Membrane binding and targetting of GAG proteins 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5661231 Metallothioneins bind metals 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-211999 CYP2E1 reactions 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-73614 Pyrimidine salvage reactions 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-937039 IRAK1 recruits IKK complex 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-189451 Heme biosynthesis 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-418889 Ligand-independent caspase activation via DCC 0.999999999970246 -2.97538352319753e-11 11 0 0 32 10285 R-HSA-5693538 Homology Directed Repair 0.999999999970286 -2.97138555298907e-11 138 0 0 32 10285 R-HSA-379724 tRNA Aminoacylation 0.999999999970776 -2.92239049116839e-11 45 0 0 32 10285 R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.999999999970776 -2.92239049116839e-11 45 0 0 32 10285 R-HSA-8854214 TBC/RABGAPs 0.999999999970776 -2.92239049116839e-11 45 0 0 32 10285 R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.999999999970776 -2.92239049116839e-11 45 0 0 32 10285 R-HSA-166658 Complement cascade 0.999999999970776 -2.92239049116839e-11 45 0 0 32 10285 R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.999999999970776 -2.92239049116839e-11 45 0 0 32 10285 R-HSA-6811438 Intra-Golgi traffic 0.999999999970776 -2.92239049116839e-11 45 0 0 32 10285 R-HSA-977225 Amyloid fiber formation 0.999999999971394 -2.86061183742938e-11 101 0 0 32 10285 R-HSA-1236975 Antigen processing-Cross presentation 0.999999999971394 -2.86061183742938e-11 101 0 0 32 10285 R-HSA-69239 Synthesis of DNA 0.999999999971394 -2.86061183742938e-11 101 0 0 32 10285 R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 0.999999999972082 -2.79179989952283e-11 75 0 0 32 10285 R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.999999999972082 -2.79179989952283e-11 75 0 0 32 10285 R-HSA-8854518 AURKA Activation by TPX2 0.999999999972082 -2.79179989952283e-11 75 0 0 32 10285 R-HSA-5654738 Signaling by FGFR2 0.999999999972082 -2.79179989952283e-11 75 0 0 32 10285 R-HSA-202424 Downstream TCR signaling 0.999999999972833 -2.71674542346051e-11 98 0 0 32 10285 R-HSA-5693607 Processing of DNA double-strand break ends 0.999999999972833 -2.71674542346051e-11 98 0 0 32 10285 R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.999999999973186 -2.68139816979593e-11 91 0 0 32 10285 R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.999999999973186 -2.68139816979593e-11 91 0 0 32 10285 R-HSA-2980736 Peptide hormone metabolism 0.999999999973186 -2.68139816979593e-11 91 0 0 32 10285 R-HSA-73777 RNA Polymerase I Chain Elongation 0.999999999973186 -2.68139816979593e-11 91 0 0 32 10285 R-HSA-418346 Platelet homeostasis 0.999999999973186 -2.68139816979593e-11 91 0 0 32 10285 R-HSA-3108214 SUMOylation of DNA damage response and repair proteins 0.999999999973711 -2.628939712181e-11 78 0 0 32 10285 R-HSA-5619115 Disorders of transmembrane transporters 0.999999999973753 -2.62466015634762e-11 76 0 0 32 10285 R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.999999999973753 -2.62466015634762e-11 76 0 0 32 10285 R-HSA-5693606 DNA Double Strand Break Response 0.999999999973753 -2.62466015634762e-11 76 0 0 32 10285 R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.999999999973753 -2.62466015634762e-11 76 0 0 32 10285 R-HSA-1169408 ISG15 antiviral mechanism 0.999999999973753 -2.62466015634762e-11 76 0 0 32 10285 R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.999999999973753 -2.62466015634762e-11 76 0 0 32 10285 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-194223 HDL-mediated lipid transport 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-5654720 PI-3K cascade:FGFR4 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-5654719 SHC-mediated cascade:FGFR4 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-8876384 Listeria monocytogenes entry into host cells 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-8874081 MET activates PTK2 signaling 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-69186 Lagging Strand Synthesis 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-190241 FGFR2 ligand binding and activation 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-1643713 Signaling by EGFR in Cancer 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-5654706 FRS-mediated FGFR3 signaling 0.99999999997412 -2.58802835080508e-11 20 0 0 32 10285 R-HSA-1369007 Mitochondrial ABC transporters 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-399710 Activation of AMPA receptors 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-69560 Transcriptional activation of p53 responsive genes 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-5603037 IRAK4 deficiency (TLR5) 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-75944 Transcription from mitochondrial promoters 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-427975 Proton/oligopeptide cotransporters 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-8849474 PTK6 Activates STAT3 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A) 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-447115 Interleukin-12 signaling 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-1251932 PLCG1 events in ERBB2 signaling 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-176034 Interactions of Tat with host cellular proteins 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-209563 Axonal growth stimulation 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-209905 Catecholamine biosynthesis 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-173107 Binding and entry of HIV virion 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-6803544 Ion influx/efflux at host-pathogen interface 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-112126 ALKBH3 mediated reversal of alkylation damage 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-4551638 SUMOylation of chromatin organization proteins 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-204626 Hypusine synthesis from eIF5A-lysine 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-3000497 Scavenging by Class H Receptors 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-1855191 Synthesis of IPs in the nucleus 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-5083630 Defective LFNG causes SCDO3 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-140179 Amine Oxidase reactions 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-8848584 Wax biosynthesis 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-165158 Activation of AKT2 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-6783984 Glycine degradation 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-442745 Activation of CaMK IV 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-1296061 HCN channels 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-1296025 ATP sensitive Potassium channels 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-2473224 Antagonism of Activin by Follistatin 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-173736 Alternative complement activation 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-112313 Neurotransmitter uptake and Metabolism In Glial Cells 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-379401 Dopamine clearance from the synaptic cleft 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-428776 Class II GLUTs 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-1296053 Classical Kir channels 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-417973 Adenosine P1 receptors 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-428542 Regulation of Commissural axon pathfinding by Slit and Robo 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-390650 Histamine receptors 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-8847453 Synthesis of PIPs in the nucleus 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-194306 Neurophilin interactions with VEGF and VEGFR 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-8935690 Miscellaneous digestion events 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-167060 NGF processing 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-6807047 Cholesterol biosynthesis via desmosterol 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-6807062 Cholesterol biosynthesis via lathosterol 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-3878781 Glycogen storage disease type IV (GBE1) 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-211163 AKT-mediated inactivation of FOXO1A 0.999999999974208 -2.57922533860842e-11 4 0 0 32 10285 R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.999999999974294 -2.57061360669914e-11 42 0 0 32 10285 R-HSA-373752 Netrin-1 signaling 0.999999999974294 -2.57061360669914e-11 42 0 0 32 10285 R-HSA-168253 Host Interactions with Influenza Factors 0.999999999974294 -2.57061360669914e-11 42 0 0 32 10285 R-HSA-1461957 Beta defensins 0.999999999974294 -2.57061360669914e-11 42 0 0 32 10285 R-HSA-983189 Kinesins 0.999999999974294 -2.57061360669914e-11 42 0 0 32 10285 R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.999999999974294 -2.57061360669914e-11 42 0 0 32 10285 R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.999999999974294 -2.57061360669914e-11 42 0 0 32 10285 R-HSA-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 0.999999999974322 -2.56777607797832e-11 84 0 0 32 10285 R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-380994 ATF4 activates genes 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-5654716 Downstream signaling of activated FGFR4 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-1482788 Acyl chain remodelling of PC 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-977606 Regulation of Complement cascade 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-901042 Calnexin/calreticulin cycle 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-6783589 Interleukin-6 family signaling 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-77387 Insulin receptor recycling 0.999999999974391 -2.56092992955413e-11 27 0 0 32 10285 R-HSA-5627123 RHO GTPases activate PAKs 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-389977 Post-chaperonin tubulin folding pathway 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-5654693 FRS-mediated FGFR1 signaling 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-3371571 HSF1-dependent transactivation 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-5654699 SHC-mediated cascade:FGFR2 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-389948 PD-1 signaling 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-379726 Mitochondrial tRNA aminoacylation 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-428930 Thromboxane signalling through TP receptor 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-5365859 RA biosynthesis pathway 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-392170 ADP signalling through P2Y purinoceptor 12 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-5654695 PI-3K cascade:FGFR2 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-8855121 VLDL interactions 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-112409 RAF-independent MAPK1/3 activation 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-5205685 Pink/Parkin Mediated Mitophagy 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-73980 RNA Polymerase III Transcription Termination 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-8863678 Neurodegenerative Diseases 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-5205647 Mitophagy 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 0.999999999974471 -2.55287446598396e-11 23 0 0 32 10285 R-HSA-451307 Activation of Na-permeable Kainate Receptors 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-156582 Acetylation 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-192905 vRNP Assembly 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-888568 GABA synthesis 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-203754 NOSIP mediated eNOS trafficking 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-428559 Proton-coupled neutral amino acid transporters 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3858516 Glycogen storage disease type 0 (liver GYS2) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-166020 Transfer of LPS from LBP carrier to CD14 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-844623 The IPAF inflammasome 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-1299361 TWIK-related alkaline pH activated K+ channel (TALK) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3359485 Defective CD320 causes methylmalonic aciduria 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-168315 Inhibition of Host mRNA Processing and RNA Silencing 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5652227 Fructose biosynthesis 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-165160 PDE3B signalling 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-164939 Nef mediated downregulation of CD28 cell surface expression 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5683177 Defective ABCC8 can cause hypoglycemias and hyperglycemias 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-8854521 Interaction between PHLDA1 and AURKA 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5602566 TICAM1 deficiency - HSE 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3359478 Defective MUT causes methylmalonic aciduria mut type 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-187042 TRKA activation by NGF 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-68881 Mitotic Metaphase/Anaphase Transition 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-75102 C6 deamination of adenosine 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-75896 Plasmalogen biosynthesis 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-114294 Activation, translocation and oligomerization of BAX 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-111457 Release of apoptotic factors from the mitochondria 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5357609 Glycogen storage disease type II (GAA) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-168268 Virus Assembly and Release 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-141424 Amplification of signal from the kinetochores 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-380612 Metabolism of serotonin 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-351143 Agmatine biosynthesis 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-177162 Conjugation of phenylacetate with glutamine 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-77042 Formation of editosomes by ADAR proteins 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-1483101 Synthesis of PS 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3359475 Defective MMAA causes methylmalonic aciduria type cblA 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-198765 Signalling to ERK5 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-1483152 Hydrolysis of LPE 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3814836 Glycogen storage disease type XV (GYG1) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3642279 TGFBR2 MSI Frameshift Mutants in Cancer 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-168316 Assembly of Viral Components at the Budding Site 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-75064 mRNA Editing: A to I Conversion 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-211994 Sterols are 12-hydroxylated by CYP8B1 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-111452 Activation and oligomerization of BAK protein 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-141334 PAOs oxidise polyamines to amines 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-1614603 Cysteine formation from homocysteine 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-8849175 Threonine catabolism 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-916853 Degradation of GABA 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-111995 phospho-PLA2 pathway 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-71737 Pyrophosphate hydrolysis 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-168277 Influenza Virus Induced Apoptosis 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5619107 Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-205017 NFG and proNGF binds to p75NTR 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-3359469 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-6804754 Regulation of TP53 Expression 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-8942233 Intestinal infectious diseases 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5602636 IKBKB deficiency causes SCID 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-432030 Transport of glycerol from adipocytes to the liver by Aquaporins 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5579031 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-70688 Proline catabolism 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-190872 Transport of connexons to the plasma membrane 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-480985 Synthesis of dolichyl-phosphate-glucose 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 0.999999999975819 -2.41814240716464e-11 2 0 0 32 10285 R-HSA-168255 Influenza Life Cycle 0.999999999975893 -2.41074239416488e-11 146 0 0 32 10285 R-HSA-5693532 DNA Double-Strand Break Repair 0.999999999976185 -2.38147445587021e-11 167 0 0 32 10285 R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.999999999976338 -2.36615057044087e-11 156 0 0 32 10285 R-HSA-6805567 Keratinization 0.999999999976445 -2.35550442184496e-11 214 0 0 32 10285 R-HSA-212165 Epigenetic regulation of gene expression 0.999999999976702 -2.32983224597237e-11 151 0 0 32 10285 R-HSA-162599 Late Phase of HIV Life Cycle 0.999999999976761 -2.32389947756592e-11 139 0 0 32 10285 R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.99999999997696 -2.3040315333832e-11 124 0 0 32 10285 R-HSA-1989781 PPARA activates gene expression 0.99999999997696 -2.3040315333832e-11 124 0 0 32 10285 R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-8849932 SALM protein interactions at the synapses 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-445144 Signal transduction by L1 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-5423646 Aflatoxin activation and detoxification 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-5654689 PI-3K cascade:FGFR1 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-2022870 Chondroitin sulfate biosynthesis 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-210745 Regulation of gene expression in beta cells 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-69618 Mitotic Spindle Checkpoint 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-6807004 Negative regulation of MET activity 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-5654688 SHC-mediated cascade:FGFR1 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-2028269 Signaling by Hippo 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-1181150 Signaling by NODAL 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-3000480 Scavenging by Class A Receptors 0.999999999977004 -2.29960202428299e-11 21 0 0 32 10285 R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.999999999977352 -2.26479351702439e-11 81 0 0 32 10285 R-HSA-70326 Glucose metabolism 0.999999999977352 -2.26479351702439e-11 81 0 0 32 10285 R-HSA-2408522 Selenoamino acid metabolism 0.999999999977433 -2.25674164453084e-11 121 0 0 32 10285 R-HSA-1500620 Meiosis 0.999999999977433 -2.25674164453084e-11 121 0 0 32 10285 R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.999999999977442 -2.25579028120514e-11 68 0 0 32 10285 R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.999999999977442 -2.25579028120514e-11 68 0 0 32 10285 R-HSA-1169091 Activation of NF-kappaB in B cells 0.999999999977442 -2.25579028120514e-11 68 0 0 32 10285 R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.999999999977442 -2.25579028120514e-11 68 0 0 32 10285 R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.999999999977442 -2.25579028120514e-11 68 0 0 32 10285 R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 0.999999999978019 -2.19812739674657e-11 41 0 0 32 10285 R-HSA-5696400 Dual Incision in GG-NER 0.999999999978019 -2.19812739674657e-11 41 0 0 32 10285 R-HSA-5654743 Signaling by FGFR4 0.999999999978019 -2.19812739674657e-11 41 0 0 32 10285 R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.999999999978019 -2.19812739674657e-11 41 0 0 32 10285 R-HSA-5620924 Intraflagellar transport 0.999999999978019 -2.19812739674657e-11 41 0 0 32 10285 R-HSA-74158 RNA Polymerase III Transcription 0.999999999978019 -2.19812739674657e-11 41 0 0 32 10285 R-HSA-69002 DNA Replication Pre-Initiation 0.999999999978039 -2.19612263120391e-11 86 0 0 32 10285 R-HSA-68874 M/G1 Transition 0.999999999978039 -2.19612263120391e-11 86 0 0 32 10285 R-HSA-5632684 Hedgehog 'on' state 0.999999999978039 -2.19612263120391e-11 86 0 0 32 10285 R-HSA-3322077 Glycogen synthesis 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5682910 LGI-ADAM interactions 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-205043 NRIF signals cell death from the nucleus 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-156581 Methylation 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-211935 Fatty acids 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5358508 Mismatch Repair 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-69183 Processive synthesis on the lagging strand 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-3371568 Attenuation phase 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-69298 Association of licensing factors with the pre-replicative complex 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-111447 Activation of BAD and translocation to mitochondria 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-391903 Eicosanoid ligand-binding receptors 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-2046106 alpha-linolenic acid (ALA) metabolism 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-68884 Mitotic Telophase/Cytokinesis 0.999999999978051 -2.19487356029115e-11 15 0 0 32 10285 R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.999999999978226 -2.1773826404872e-11 137 0 0 32 10285 R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.999999999978226 -2.1773826404872e-11 137 0 0 32 10285 R-HSA-8856828 Clathrin-mediated endocytosis 0.999999999978226 -2.1773826404872e-11 137 0 0 32 10285 R-HSA-5263617 Metabolism of ingested MeSeO2H into MeSeH 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-140180 COX reactions 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-3248023 Regulation by TREX1 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-171286 Synthesis and processing of ENV and VPU 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-2534343 Interaction With Cumulus Cells 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-162585 Uncoating of the HIV Virion 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-112122 ALKBH2 mediated reversal of alkylation damage 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5657655 MGMT-mediated DNA damage reversal 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-163316 Mitochondrial transcription termination 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-2023837 Signaling by FGFR2 amplification mutants 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-164516 Minus-strand DNA synthesis 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5602415 UNC93B1 deficiency - HSE 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1299344 TWIK-related spinal cord K+ channel (TRESK) 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-6809583 Retinoid metabolism disease events 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-389542 NADPH regeneration 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5602410 TLR3 deficiency - HSE 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1483196 PI and PC transport between ER and Golgi membranes 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-169131 Inhibition of PKR 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-8853333 Signaling by FGFR2 fusions 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1839120 Signaling by FGFR1 amplification mutants 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1300645 Acrosome Reaction 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5340573 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-975574 Reactions specific to the hybrid N-glycan synthesis pathway 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-3359474 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1222499 Response of Mtb to phagocytosis 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1839128 FGFR4 mutant receptor activation 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-2033515 t(4;14) translocations of FGFR3 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-2466712 Biosynthesis of A2E, implicated in retinal degradation 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-2408552 Methylation of MeSeH for excretion 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-3359457 Defective GIF causes intrinsic factor deficiency 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-164525 Plus-strand DNA synthesis 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1222352 Latent infection of Homo sapiens with Mycobacterium tuberculosis 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5250982 Toxicity of tetanus toxin (TeNT) 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1855231 Synthesis of IPs in the ER lumen 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1483076 Synthesis of CL 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-162589 Reverse Transcription of HIV RNA 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-168330 Viral RNP Complexes in the Host Cell Nucleus 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-3359454 Defective TCN2 causes hereditary megaloblastic anemia 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-1222449 Mtb iron assimilation by chelation 0.999999999978371 -2.16285474773092e-11 1 0 0 32 10285 R-HSA-5689880 Ub-specific processing proteases 0.99999999997908 -2.09198145712491e-11 223 0 0 32 10285 R-HSA-157579 Telomere Maintenance 0.999999999979126 -2.08737315406485e-11 82 0 0 32 10285 R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.999999999979126 -2.08737315406485e-11 82 0 0 32 10285 R-HSA-380287 Centrosome maturation 0.999999999979126 -2.08737315406485e-11 82 0 0 32 10285 R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.999999999979126 -2.08737315406485e-11 82 0 0 32 10285 R-HSA-70153 Glucose transport 0.999999999979193 -2.08074062594049e-11 46 0 0 32 10285 R-HSA-1660662 Glycosphingolipid metabolism 0.999999999979193 -2.08074062594049e-11 46 0 0 32 10285 R-HSA-4615885 SUMOylation of DNA replication proteins 0.999999999979193 -2.08074062594049e-11 46 0 0 32 10285 R-HSA-446652 Interleukin-1 signaling 0.999999999979193 -2.08074062594049e-11 46 0 0 32 10285 R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.999999999979193 -2.08074062594049e-11 46 0 0 32 10285 R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.999999999979605 -2.03946616009257e-11 104 0 0 32 10285 R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins 0.999999999979605 -2.03946616009257e-11 104 0 0 32 10285 R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.999999999979924 -2.00762936104922e-11 83 0 0 32 10285 R-HSA-73942 DNA Damage Reversal 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-72731 Recycling of eIF2:GDP 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-977347 Serine biosynthesis 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-68952 DNA replication initiation 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-3656532 TGFBR1 KD Mutants in Cancer 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-164944 Nef and signal transduction 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-196836 Vitamin C (ascorbate) metabolism 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-2142789 Ubiquinol biosynthesis 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-73928 Depyrimidination 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-1483115 Hydrolysis of LPC 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-5358493 Synthesis of diphthamide-EEF2 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-5576890 Phase 3 - rapid repolarisation 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-5632681 Ligand-receptor interactions 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-444821 Relaxin receptors 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-177128 Conjugation of salicylate with glycine 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-77111 Synthesis of Ketone Bodies 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-110329 Cleavage of the damaged pyrimidine 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-196783 Coenzyme A biosynthesis 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-70921 Histidine catabolism 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-1483148 Synthesis of PG 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-448424 Interleukin-17 signaling 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-1482883 Acyl chain remodeling of DAG and TAG 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-6787450 tRNA modification in the mitochondrion 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-194313 VEGF ligand-receptor interactions 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-804914 Transport of fatty acids 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-174430 Telomere C-strand synthesis initiation 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 0.999999999980245 -1.97553913100372e-11 8 0 0 32 10285 R-HSA-72689 Formation of a pool of free 40S subunits 0.999999999980369 -1.9630970240215e-11 105 0 0 32 10285 R-HSA-5689603 UCH proteinases 0.999999999980369 -1.9630970240215e-11 105 0 0 32 10285 R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.999999999980518 -1.94817329650816e-11 158 0 0 32 10285 R-HSA-3214847 HATs acetylate histones 0.999999999980844 -1.91560023216375e-11 143 0 0 32 10285 R-HSA-453279 Mitotic G1-G1/S phases 0.999999999980844 -1.91560023216375e-11 143 0 0 32 10285 R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.999999999980864 -1.91358938051671e-11 59 0 0 32 10285 R-HSA-4641258 Degradation of DVL 0.999999999980864 -1.91358938051671e-11 59 0 0 32 10285 R-HSA-2142753 Arachidonic acid metabolism 0.999999999980864 -1.91358938051671e-11 59 0 0 32 10285 R-HSA-352230 Amino acid transport across the plasma membrane 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-180786 Extension of Telomeres 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-6804758 Regulation of TP53 Activity through Acetylation 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-1839124 FGFR1 mutant receptor activation 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-8875878 MET promotes cell motility 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-75067 Processing of Capped Intronless Pre-mRNA 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-114452 Activation of BH3-only proteins 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-5654733 Negative regulation of FGFR4 signaling 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-5339562 Uptake and actions of bacterial toxins 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-1296065 Inwardly rectifying K+ channels 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-418360 Platelet calcium homeostasis 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-5654687 Downstream signaling of activated FGFR1 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-73772 RNA Polymerase I Promoter Escape 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-70614 Amino acid synthesis and interconversion (transamination) 0.999999999980998 -1.90024485441009e-11 31 0 0 32 10285 R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.999999999981123 -1.8876697052499e-11 108 0 0 32 10285 R-HSA-5610783 Degradation of GLI2 by the proteasome 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-5610780 Degradation of GLI1 by the proteasome 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-72702 Ribosomal scanning and start codon recognition 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.999999999981138 -1.88623943770313e-11 61 0 0 32 10285 R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.999999999981344 -1.86555938724285e-11 117 0 0 32 10285 R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.999999999981344 -1.86555938724285e-11 117 0 0 32 10285 R-HSA-442982 Ras activation uopn Ca2+ infux through NMDA receptor 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-5223345 Miscellaneous transport and binding events 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-5576886 Phase 4 - resting membrane potential 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-176412 Phosphorylation of the APC/C 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-156584 Cytosolic sulfonation of small molecules 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-110320 Translesion Synthesis by POLH 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-416700 Other semaphorin interactions 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-3928664 Ephrin signaling 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-190861 Gap junction assembly 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-71403 Citric acid cycle (TCA cycle) 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-8876725 Protein methylation 0.999999999981395 -1.86051454747611e-11 19 0 0 32 10285 R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-435354 Zinc transporters 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-937072 TRAF6 mediated induction of TAK1 complex 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-156711 Polo-like kinase mediated events 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-140534 Ligand-dependent caspase activation 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-2033519 Activated point mutants of FGFR2 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-192456 Digestion of dietary lipid 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-1482922 Acyl chain remodelling of PI 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-2142845 Hyaluronan metabolism 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-5656121 Translesion synthesis by POLI 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-139853 Elevation of cytosolic Ca2+ levels 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-70221 Glycogen breakdown (glycogenolysis) 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-442729 CREB phosphorylation through the activation of CaMKII 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-189445 Metabolism of porphyrins 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-622312 Inflammasomes 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-432142 Platelet sensitization by LDL 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-199220 Vitamin B5 (pantothenate) metabolism 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-3296482 Defects in vitamin and cofactor metabolism 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-193639 p75NTR signals via NF-kB 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-5655862 Translesion synthesis by POLK 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-196299 Beta-catenin phosphorylation cascade 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-3232118 SUMOylation of transcription factors 0.999999999981544 -1.8455666209509e-11 17 0 0 32 10285 R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 0.999999999981901 -1.80991069217716e-11 127 0 0 32 10285 R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.999999999982081 -1.79189800405407e-11 72 0 0 32 10285 R-HSA-68949 Orc1 removal from chromatin 0.999999999982081 -1.79189800405407e-11 72 0 0 32 10285 R-HSA-69052 Switching of origins to a post-replicative state 0.999999999982081 -1.79189800405407e-11 72 0 0 32 10285 R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.999999999982081 -1.79189800405407e-11 72 0 0 32 10285 R-HSA-69202 Cyclin E associated events during G1/S transition 0.999999999982081 -1.79189800405407e-11 72 0 0 32 10285 R-HSA-774815 Nucleosome assembly 0.999999999982081 -1.79189800405407e-11 72 0 0 32 10285 R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.999999999982081 -1.79189800405407e-11 72 0 0 32 10285 R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.999999999982148 -1.78521726819561e-11 120 0 0 32 10285 R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.999999999982148 -1.78521726819561e-11 120 0 0 32 10285 R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.999999999982297 -1.77028374423072e-11 57 0 0 32 10285 R-HSA-429914 Deadenylation-dependent mRNA decay 0.999999999982297 -1.77028374423072e-11 57 0 0 32 10285 R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.999999999982297 -1.77028374423072e-11 57 0 0 32 10285 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.999999999982488 -1.75116427045355e-11 311 0 0 32 10285 R-HSA-442742 CREB phosphorylation through the activation of Ras 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-5654732 Negative regulation of FGFR3 signaling 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-202040 G-protein activation 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-5218920 VEGFR2 mediated vascular permeability 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-1482839 Acyl chain remodelling of PE 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-375170 CDO in myogenesis 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-525793 Myogenesis 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-390918 Peroxisomal lipid metabolism 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-196807 Nicotinate metabolism 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-72086 mRNA Capping 0.999999999982771 -1.72287906342892e-11 29 0 0 32 10285 R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.999999999982846 -1.71536801044703e-11 74 0 0 32 10285 R-HSA-6802957 Oncogenic MAPK signaling 0.999999999982846 -1.71536801044703e-11 74 0 0 32 10285 R-HSA-212300 PRC2 methylates histones and DNA 0.999999999982846 -1.71536801044703e-11 74 0 0 32 10285 R-HSA-174824 Lipoprotein metabolism 0.999999999982846 -1.71536801044703e-11 74 0 0 32 10285 R-HSA-69300 Removal of licensing factors from origins 0.999999999982846 -1.71536801044703e-11 74 0 0 32 10285 R-HSA-2299718 Condensation of Prophase Chromosomes 0.999999999982846 -1.71536801044703e-11 74 0 0 32 10285 R-HSA-611105 Respiratory electron transport 0.999999999983003 -1.69966654903712e-11 92 0 0 32 10285 R-HSA-192823 Viral mRNA Translation 0.999999999983003 -1.69966654903712e-11 92 0 0 32 10285 R-HSA-381119 Unfolded Protein Response (UPR) 0.999999999983003 -1.69966654903712e-11 92 0 0 32 10285 R-HSA-156902 Peptide chain elongation 0.999999999983003 -1.69966654903712e-11 92 0 0 32 10285 R-HSA-373080 Class B/2 (Secretin family receptors) 0.999999999983003 -1.69966654903712e-11 92 0 0 32 10285 R-HSA-204005 COPII (Coat Protein 2) Mediated Vesicle Transport 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-909733 Interferon alpha/beta signaling 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-68867 Assembly of the pre-replicative complex 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-6806834 Signaling by MET 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-427359 SIRT1 negatively regulates rRNA Expression 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-388841 Costimulation by the CD28 family 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-5619084 ABC transporter disorders 0.999999999983471 -1.65291433972184e-11 69 0 0 32 10285 R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.99999999998366 -1.63404963837362e-11 247 0 0 32 10285 R-HSA-5368286 Mitochondrial translation initiation 0.999999999983929 -1.60709705191174e-11 87 0 0 32 10285 R-HSA-5419276 Mitochondrial translation termination 0.999999999983929 -1.60709705191174e-11 87 0 0 32 10285 R-HSA-453276 Regulation of mitotic cell cycle 0.999999999983929 -1.60709705191174e-11 87 0 0 32 10285 R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.999999999983929 -1.60709705191174e-11 87 0 0 32 10285 R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.999999999983929 -1.60709705191174e-11 87 0 0 32 10285 R-HSA-72737 Cap-dependent Translation Initiation 0.99999999998399 -1.6009640330269e-11 125 0 0 32 10285 R-HSA-72613 Eukaryotic Translation Initiation 0.99999999998399 -1.6009640330269e-11 125 0 0 32 10285 R-HSA-159227 Transport of the SLBP independent Mature mRNA 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-5694530 Cargo concentration in the ER 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-165054 Rev-mediated nuclear export of HIV RNA 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-3928663 EPHA-mediated growth cone collapse 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-390522 Striated Muscle Contraction 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-192105 Synthesis of bile acids and bile salts 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-1483166 Synthesis of PA 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-73847 Purine metabolism 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-113510 E2F mediated regulation of DNA replication 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-5654727 Negative regulation of FGFR2 signaling 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-5656169 Termination of translesion DNA synthesis 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 0.999999999984043 -1.59567356002416e-11 34 0 0 32 10285 R-HSA-6809371 Formation of the cornified envelope 0.999999999984066 -1.59340880377809e-11 71 0 0 32 10285 R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.999999999984066 -1.59340880377809e-11 71 0 0 32 10285 R-HSA-73856 RNA Polymerase II Transcription Termination 0.999999999984066 -1.59340880377809e-11 71 0 0 32 10285 R-HSA-109688 Cleavage of Growing Transcript in the Termination Region 0.999999999984066 -1.59340880377809e-11 71 0 0 32 10285 R-HSA-400253 Circadian Clock 0.999999999984066 -1.59340880377809e-11 71 0 0 32 10285 R-HSA-381753 Olfactory Signaling Pathway 0.999999999984089 -1.59109656303674e-11 391 0 0 32 10285 R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.999999999984141 -1.58592371145022e-11 191 0 0 32 10285 R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.999999999984375 -1.56249378181247e-11 51 0 0 32 10285 R-HSA-1461973 Defensins 0.999999999984375 -1.56249378181247e-11 51 0 0 32 10285 R-HSA-6799198 Complex I biogenesis 0.999999999984375 -1.56249378181247e-11 51 0 0 32 10285 R-HSA-383280 Nuclear Receptor transcription pathway 0.999999999984375 -1.56249378181247e-11 51 0 0 32 10285 R-HSA-171306 Packaging Of Telomere Ends 0.999999999984375 -1.56249378181247e-11 51 0 0 32 10285 R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.999999999984375 -1.56249378181247e-11 51 0 0 32 10285 R-HSA-201451 Signaling by BMP 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-392154 Nitric oxide stimulates guanylate cyclase 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-5260271 Diseases of Immune System 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-156588 Glucuronidation 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-171052 LDL-mediated lipid transport 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-191273 Cholesterol biosynthesis 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-70895 Branched-chain amino acid catabolism 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-937041 IKK complex recruitment mediated by RIP1 0.999999999984407 -1.55931663729965e-11 24 0 0 32 10285 R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 0.999999999984643 -1.53568711573431e-11 77 0 0 32 10285 R-HSA-2262749 Cellular response to hypoxia 0.999999999984643 -1.53568711573431e-11 77 0 0 32 10285 R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.999999999984643 -1.53568711573431e-11 77 0 0 32 10285 R-HSA-167172 Transcription of the HIV genome 0.999999999984643 -1.53568711573431e-11 77 0 0 32 10285 R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.999999999984643 -1.53568711573431e-11 77 0 0 32 10285 R-HSA-69304 Regulation of DNA replication 0.999999999984643 -1.53568711573431e-11 77 0 0 32 10285 R-HSA-1236974 ER-Phagosome pathway 0.999999999984691 -1.53088039063661e-11 85 0 0 32 10285 R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.999999999984691 -1.53088039063661e-11 85 0 0 32 10285 R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.999999999984836 -1.51640637211411e-11 89 0 0 32 10285 R-HSA-190236 Signaling by FGFR 0.999999999984836 -1.51640637211411e-11 89 0 0 32 10285 R-HSA-3371556 Cellular response to heat stress 0.999999999984836 -1.51640637211411e-11 89 0 0 32 10285 R-HSA-211859 Biological oxidations 0.99999999998521 -1.47902396408724e-11 222 0 0 32 10285 R-HSA-2555396 Mitotic Metaphase and Anaphase 0.999999999985561 -1.44387371501721e-11 180 0 0 32 10285 R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.999999999985682 -1.43180240276131e-11 56 0 0 32 10285 R-HSA-69541 Stabilization of p53 0.999999999985682 -1.43180240276131e-11 56 0 0 32 10285 R-HSA-4641257 Degradation of AXIN 0.999999999985682 -1.43180240276131e-11 56 0 0 32 10285 R-HSA-381038 XBP1(S) activates chaperone genes 0.999999999985682 -1.43180240276131e-11 56 0 0 32 10285 R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.999999999985682 -1.43180240276131e-11 56 0 0 32 10285 R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.999999999986438 -1.35624202669955e-11 179 0 0 32 10285 R-HSA-68882 Mitotic Anaphase 0.999999999986438 -1.35624202669955e-11 179 0 0 32 10285 R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.999999999986438 -1.35624202669955e-11 179 0 0 32 10285 R-HSA-913531 Interferon Signaling 0.999999999986866 -1.31336180637733e-11 201 0 0 32 10285 R-HSA-69620 Cell Cycle Checkpoints 0.999999999986866 -1.31336180637733e-11 201 0 0 32 10285 R-HSA-72312 rRNA processing 0.999999999986866 -1.31336180637733e-11 201 0 0 32 10285 R-HSA-8852135 Protein ubiquitination 0.999999999987546 -1.2453904630887e-11 62 0 0 32 10285 R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.999999999987546 -1.2453904630887e-11 62 0 0 32 10285 R-HSA-1445148 Translocation of GLUT4 to the plasma membrane 0.999999999987546 -1.2453904630887e-11 62 0 0 32 10285 R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.999999999987546 -1.2453904630887e-11 62 0 0 32 10285 R-HSA-72649 Translation initiation complex formation 0.999999999987546 -1.2453904630887e-11 62 0 0 32 10285 R-HSA-1268020 Mitochondrial protein import 0.999999999987546 -1.2453904630887e-11 62 0 0 32 10285 R-HSA-72187 mRNA 3'-end processing 0.999999999987546 -1.2453904630887e-11 62 0 0 32 10285 R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.999999999987763 -1.22372324044614e-11 70 0 0 32 10285 R-HSA-5658442 Regulation of RAS by GAPs 0.999999999987763 -1.22372324044614e-11 70 0 0 32 10285 R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.999999999987763 -1.22372324044614e-11 70 0 0 32 10285 R-HSA-168254 Influenza Infection 0.999999999987874 -1.21261997245768e-11 157 0 0 32 10285 R-HSA-5357905 Regulation of TNFR1 signaling 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-5654726 Negative regulation of FGFR1 signaling 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-180910 Vpr-mediated nuclear import of PICs 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-180746 Nuclear import of Rev protein 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-1638074 Keratan sulfate/keratin metabolism 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-392518 Signal amplification 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-1839126 FGFR2 mutant receptor activation 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-1222556 ROS, RNS production in phagocytes 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-389356 CD28 co-stimulation 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-202433 Generation of second messenger molecules 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-186712 Regulation of beta-cell development 0.99999999998797 -1.20296582938942e-11 33 0 0 32 10285 R-HSA-72764 Eukaryotic Translation Termination 0.99999999998807 -1.19299433581794e-11 96 0 0 32 10285 R-HSA-156842 Eukaryotic Translation Elongation 0.99999999998807 -1.19299433581794e-11 96 0 0 32 10285 R-HSA-4086400 PCP/CE pathway 0.99999999998807 -1.19299433581794e-11 96 0 0 32 10285 R-HSA-1660661 Sphingolipid de novo biosynthesis 0.999999999988091 -1.19088105683041e-11 44 0 0 32 10285 R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.999999999988091 -1.19088105683041e-11 44 0 0 32 10285 R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 0.999999999988091 -1.19088105683041e-11 44 0 0 32 10285 R-HSA-917937 Iron uptake and transport 0.999999999988091 -1.19088105683041e-11 44 0 0 32 10285 R-HSA-109606 Intrinsic Pathway for Apoptosis 0.999999999988091 -1.19088105683041e-11 44 0 0 32 10285 R-HSA-5668914 Diseases of metabolism 0.999999999988091 -1.19088105683041e-11 44 0 0 32 10285 R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.999999999988126 -1.18744315968788e-11 65 0 0 32 10285 R-HSA-75955 RNA Polymerase II Transcription Elongation 0.999999999988126 -1.18744315968788e-11 65 0 0 32 10285 R-HSA-5334118 DNA methylation 0.999999999988126 -1.18744315968788e-11 65 0 0 32 10285 R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.999999999988126 -1.18744315968788e-11 65 0 0 32 10285 R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.999999999988126 -1.18744315968788e-11 65 0 0 32 10285 R-HSA-913709 O-linked glycosylation of mucins 0.999999999988126 -1.18744315968788e-11 65 0 0 32 10285 R-HSA-112382 Formation of RNA Pol II elongation complex 0.999999999988126 -1.18744315968788e-11 65 0 0 32 10285 R-HSA-453274 Mitotic G2-G2/M phases 0.999999999988233 -1.17671444583639e-11 184 0 0 32 10285 R-HSA-5663205 Infectious disease 0.999999999988326 -1.16740824418769e-11 388 0 0 32 10285 R-HSA-5387390 Hh mutants abrogate ligand secretion 0.999999999988676 -1.13238627007134e-11 60 0 0 32 10285 R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.999999999988676 -1.13238627007134e-11 60 0 0 32 10285 R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.999999999988676 -1.13238627007134e-11 60 0 0 32 10285 R-HSA-6802952 Signaling by BRAF and RAF fusions 0.999999999988676 -1.13238627007134e-11 60 0 0 32 10285 R-HSA-6784531 tRNA processing in the nucleus 0.999999999988676 -1.13238627007134e-11 60 0 0 32 10285 R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 0.999999999988676 -1.13238627007134e-11 60 0 0 32 10285 R-HSA-162906 HIV Infection 0.999999999988786 -1.12142565346159e-11 236 0 0 32 10285 R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-5620916 VxPx cargo-targeting to cilium 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-5655332 Signaling by FGFR3 in disease 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-166208 mTORC1-mediated signalling 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-901032 ER Quality Control Compartment (ERQC) 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-202131 Metabolism of nitric oxide 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-77595 Processing of Intronless Pre-mRNAs 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-5621575 CD209 (DC-SIGN) signaling 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-166663 Initial triggering of complement 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-1482801 Acyl chain remodelling of PS 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-69273 Cyclin A/B1 associated events during G2/M transition 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-389513 CTLA4 inhibitory signaling 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-5654712 FRS-mediated FGFR4 signaling 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-8853338 Signaling by FGFR3 point mutants in cancer 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-198753 ERK/MAPK targets 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-373753 Nephrin interactions 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-203765 eNOS activation and regulation 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-4641263 Regulation of FZD by ubiquitination 0.999999999988789 -1.1211321720169e-11 22 0 0 32 10285 R-HSA-111465 Apoptotic cleavage of cellular proteins 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-6783310 Fanconi Anemia Pathway 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-69236 G1 Phase 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-5674135 MAP2K and MAPK activation 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-69231 Cyclin D associated events in G1 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-5696394 DNA Damage Recognition in GG-NER 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-165159 mTOR signalling 0.999999999988938 -1.10616143839155e-11 39 0 0 32 10285 R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-209952 Peptide hormone biosynthesis 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-877312 Regulation of IFNG signaling 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-428540 Activation of Rac 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-69166 Removal of the Flap Intermediate 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-181431 Acetylcholine Binding And Downstream Events 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-419408 Lysosphingolipid and LPA receptors 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-209560 NF-kB is activated and signals survival 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-4839744 truncated APC mutants destabilize the destruction complex 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-418885 DCC mediated attractive signaling 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-418359 Reduction of cytosolic Ca++ levels 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-629602 Activation of Nicotinic Acetylcholine Receptors 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-190322 FGFR4 ligand binding and activation 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-69109 Leading Strand Synthesis 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-4839748 AMER1 mutants destabilize the destruction complex 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-174403 Glutathione synthesis and recycling 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-2024101 CS/DS degradation 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-5675482 Regulation of necroptotic cell death 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-1679131 Trafficking and processing of endosomal TLR 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-69091 Polymerase switching 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-209543 p75NTR recruits signalling complexes 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-162594 Early Phase of HIV Life Cycle 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-177504 Retrograde neurotrophin signalling 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-428790 Facilitative Na+-independent glucose transporters 0.999999999988984 -1.10164386174032e-11 14 0 0 32 10285 R-HSA-73884 Base Excision Repair 0.999999999989123 -1.08764962036483e-11 37 0 0 32 10285 R-HSA-176187 Activation of ATR in response to replication stress 0.999999999989123 -1.08764962036483e-11 37 0 0 32 10285 R-HSA-419037 NCAM1 interactions 0.999999999989123 -1.08764962036483e-11 37 0 0 32 10285 R-HSA-5689896 Ovarian tumor domain proteases 0.999999999989123 -1.08764962036483e-11 37 0 0 32 10285 R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) 0.999999999989123 -1.08764962036483e-11 37 0 0 32 10285 R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.999999999989123 -1.08764962036483e-11 37 0 0 32 10285 R-HSA-912446 Meiotic recombination 0.999999999989147 -1.08527785683779e-11 88 0 0 32 10285 R-HSA-5389840 Mitochondrial translation elongation 0.999999999989147 -1.08527785683779e-11 88 0 0 32 10285 R-HSA-674695 RNA Polymerase II Pre-transcription Events 0.999999999989147 -1.08527785683779e-11 88 0 0 32 10285 R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.999999999989147 -1.08527785683779e-11 88 0 0 32 10285 R-HSA-6803157 Antimicrobial peptides 0.999999999989257 -1.07431128222788e-11 97 0 0 32 10285 R-HSA-15869 Metabolism of nucleotides 0.999999999989257 -1.07431128222788e-11 97 0 0 32 10285 R-HSA-3229121 Glycogen storage diseases 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-110056 MAPK3 (ERK1) activation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-73929 Base-Excision Repair, AP Site Formation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-112311 Neurotransmitter Clearance In The Synaptic Cleft 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-159740 Gamma-carboxylation of protein precursors 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-8868766 rRNA processing in the mitochondrion 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-196108 Pregnenolone biosynthesis 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-74259 Purine catabolism 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-2046105 Linoleic acid (LA) metabolism 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-190377 FGFR2b ligand binding and activation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-390450 Folding of actin by CCT/TriC 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-201688 WNT mediated activation of DVL 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-425381 Bicarbonate transporters 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-167590 Nef Mediated CD4 Down-regulation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-8853334 Signaling by FGFR3 fusions in cancer 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-418890 Role of second messengers in netrin-1 signaling 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-428643 Organic anion transporters 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-70635 Urea cycle 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-168799 Neurotoxicity of clostridium toxins 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-209968 Thyroxine biosynthesis 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-190873 Gap junction degradation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-3215018 Processing and activation of SUMO 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-5687613 Diseases associated with surfactant metabolism 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-389887 Beta-oxidation of pristanoyl-CoA 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-2562578 TRIF-mediated programmed cell death 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-430116 GP1b-IX-V activation signalling 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-727802 Transport of nucleotide sugars 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-1300644 Interaction With The Zona Pellucida 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-2161522 Abacavir transport and metabolism 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-8875656 MET receptor recycling 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-5663084 Diseases of carbohydrate metabolism 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-3785653 Myoclonic epilepsy of Lafora 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-937042 IRAK2 mediated activation of TAK1 complex 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-419812 Calcitonin-like ligand receptors 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-442380 Zinc influx into cells by the SLC39 gene family 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-427601 Multifunctional anion exchangers 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-418886 Netrin mediated repulsion signals 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-74749 Signal attenuation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-193692 Regulated proteolysis of p75NTR 0.999999999989639 -1.03612584534662e-11 10 0 0 32 10285 R-HSA-428157 Sphingolipid metabolism 0.999999999989805 -1.01946966744737e-11 90 0 0 32 10285 R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.999999999989805 -1.01946966744737e-11 90 0 0 32 10285 R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.999999999989818 -1.01818110838534e-11 122 0 0 32 10285 R-HSA-201681 TCF dependent signaling in response to WNT 0.999999999990208 -9.79222329091663e-12 238 0 0 32 10285 R-HSA-73762 RNA Polymerase I Transcription Initiation 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-4570464 SUMOylation of RNA binding proteins 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-380108 Chemokine receptors bind chemokines 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.999999999990383 -9.61654361776985e-12 48 0 0 32 10285 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-4791275 Signaling by WNT in cancer 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-933541 TRAF6 mediated IRF7 activation 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-5693537 Resolution of D-Loop Structures 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-113418 Formation of the Early Elongation Complex 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-6804757 Regulation of TP53 Degradation 0.999999999990478 -9.52234527158354e-12 35 0 0 32 10285 R-HSA-5173105 O-linked glycosylation 0.999999999990621 -9.3789996099002e-12 114 0 0 32 10285 R-HSA-5696398 Nucleotide Excision Repair 0.999999999990678 -9.32152228812604e-12 112 0 0 32 10285 R-HSA-73864 RNA Polymerase I Transcription 0.999999999990678 -9.32152228812604e-12 112 0 0 32 10285 R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-5662702 Melanin biosynthesis 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-390651 Dopamine receptors 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-111448 Activation of NOXA and translocation to mitochondria 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-111463 SMAC binds to IAPs 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-1300652 Sperm:Oocyte Membrane Binding 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-157881 Cyclin B2 mediated events 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-380095 Tachykinin receptors bind tachykinins 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8875513 MET interacts with TNS proteins 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8865999 MET activates PTPN11 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-427652 Sodium-coupled phosphate cotransporters 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-112303 Electric Transmission Across Gap Junctions 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-203641 NOSTRIN mediated eNOS trafficking 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-166187 Mitochondrial Uncoupling Proteins 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-5661270 Catabolism of glucuronate to xylulose-5-phosphate 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8866423 VLDL biosynthesis 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-75157 FasL/ CD95L signaling 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-167827 The proton buffering model 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-70350 Fructose catabolism 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D) 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-391906 Leukotriene receptors 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8853383 Lysosomal oligosaccharide catabolism 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-3656535 TGFBR1 LBD Mutants in Cancer 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-71032 Propionyl-CoA catabolism 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-2142850 Hyaluronan biosynthesis and export 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-71262 Carnitine synthesis 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-112307 Transmission across Electrical Synapses 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-426048 Arachidonate production from DAG 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-6785470 tRNA processing in the mitochondrion 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8866376 Reelin signalling pathway 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-187024 NGF-independant TRKA activation 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-2161541 Abacavir metabolism 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-70370 Galactose catabolism 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-111469 SMAC-mediated apoptotic response 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-389599 Alpha-oxidation of phytanate 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-390648 Muscarinic acetylcholine receptors 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-446205 Synthesis of GDP-mannose 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-1614517 Sulfide oxidation to sulfate 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-167826 The fatty acid cycling model 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F) 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-3000471 Scavenging by Class B Receptors 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-561048 Organic anion transport 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-1483226 Synthesis of PI 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-196819 Vitamin B1 (thiamin) metabolism 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-69478 G2/M DNA replication checkpoint 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-111461 Cytochrome c-mediated apoptotic response 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-2161517 Abacavir transmembrane transport 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8852405 Signaling by MST1 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-5683678 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-68911 G2 Phase 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-111464 SMAC-mediated dissociation of IAP:caspase complexes 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-1606341 IRF3 mediated activation of type 1 IFN 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-209931 Serotonin and melatonin biosynthesis 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-8849473 PTK6 Expression 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-74713 IRS activation 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-3642278 Loss of Function of TGFBR2 in Cancer 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-1169092 Activation of RAS in B cells 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-444209 Free fatty acid receptors 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-1306955 GRB7 events in ERBB2 signaling 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-114516 Disinhibition of SNARE formation 0.999999999990727 -9.27316534750195e-12 5 0 0 32 10285 R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 0.999999999990855 -9.14459459274018e-12 149 0 0 32 10285 R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-73893 DNA Damage Bypass 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-167169 HIV Transcription Elongation 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-5654736 Signaling by FGFR1 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-6802949 Signaling by RAS mutants 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-73887 Death Receptor Signalling 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.999999999991073 -8.92665221267071e-12 50 0 0 32 10285 R-HSA-2995383 Initiation of Nuclear Envelope Reformation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-74217 Purine salvage 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-75892 Platelet Adhesion to exposed collagen 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-3270619 IRF3-mediated induction of type I IFN 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-391160 Signal regulatory protein (SIRP) family interactions 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-71240 Tryptophan catabolism 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-2408517 SeMet incorporation into proteins 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-5210891 Uptake and function of anthrax toxins 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-2995410 Nuclear Envelope Reassembly 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-211227 Activation of DNA fragmentation factor 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-425561 Sodium/Calcium exchangers 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-190375 FGFR2c ligand binding and activation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-202670 ERKs are inactivated 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-198323 AKT phosphorylates targets in the cytosol 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-977441 GABA A receptor activation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-375281 Hormone ligand-binding receptors 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-175474 Assembly Of The HIV Virion 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-75205 Dissolution of Fibrin Clot 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-2168880 Scavenging of heme from plasma 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-5626467 RHO GTPases activate IQGAPs 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-171007 p38MAPK events 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-112308 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-190239 FGFR3 ligand binding and activation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-2029481 FCGR activation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-140342 Apoptosis induced DNA fragmentation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-350054 Notch-HLH transcription pathway 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-1663150 The activation of arylsulfatases 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-1502540 Signaling by Activin 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-190372 FGFR3c ligand binding and activation 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-432047 Passive transport by Aquaporins 0.999999999991148 -8.85213978294358e-12 13 0 0 32 10285 R-HSA-114608 Platelet degranulation 0.999999999991391 -8.60877186270334e-12 132 0 0 32 10285 R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.999999999991391 -8.60877186270334e-12 132 0 0 32 10285 R-HSA-5654696 Downstream signaling of activated FGFR2 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-420092 Glucagon-type ligand receptors 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-5669034 TNFs bind their physiological receptors 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-917977 Transferrin endocytosis and recycling 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-445095 Interaction between L1 and Ankyrins 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-381042 PERK regulates gene expression 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-420029 Tight junction interactions 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-5683826 Surfactant metabolism 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-157858 Gap junction trafficking and regulation 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.99999999999146 -8.53992637585404e-12 30 0 0 32 10285 R-HSA-5633007 Regulation of TP53 Activity 0.999999999991499 -8.50123894482983e-12 162 0 0 32 10285 R-HSA-72766 Translation 0.999999999991499 -8.50123894482983e-12 162 0 0 32 10285 R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.999999999992226 -7.7739375802276e-12 49 0 0 32 10285 R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.999999999992226 -7.7739375802276e-12 49 0 0 32 10285 R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 0.999999999992226 -7.7739375802276e-12 49 0 0 32 10285 R-HSA-6783783 Interleukin-10 signaling 0.999999999992226 -7.7739375802276e-12 49 0 0 32 10285 R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.999999999992447 -7.55324589827052e-12 54 0 0 32 10285 R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.999999999992447 -7.55324589827052e-12 54 0 0 32 10285 R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 0.999999999992447 -7.55324589827052e-12 54 0 0 32 10285 R-HSA-1592230 Mitochondrial biogenesis 0.999999999992447 -7.55324589827052e-12 54 0 0 32 10285 R-HSA-69610 p53-Independent DNA Damage Response 0.999999999992447 -7.55324589827052e-12 54 0 0 32 10285 R-HSA-189200 Hexose transport 0.999999999992447 -7.55324589827052e-12 54 0 0 32 10285 R-HSA-169911 Regulation of Apoptosis 0.999999999992447 -7.55324589827052e-12 54 0 0 32 10285 R-HSA-73894 DNA Repair 0.999999999992794 -7.20591725319504e-12 316 0 0 32 10285 R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.999999999992794 -7.20582780289901e-12 373 0 0 32 10285 R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.999999999992942 -7.05761577205637e-12 113 0 0 32 10285 R-HSA-1462054 Alpha-defensins 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-75094 Formation of the Editosome 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-5340588 RNF mutants show enhanced WNT signaling and proliferation 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-391908 Prostanoid ligand receptors 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2214320 Anchoring fibril formation 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2453864 Retinoid cycle disease events 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-159424 Conjugation of carboxylic acids 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-194002 Glucocorticoid biosynthesis 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-193697 p75NTR regulates axonogenesis 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2428933 SHC-related events triggered by IGF1R 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-425986 Sodium/Proton exchangers 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-189085 Digestion of dietary carbohydrate 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-71336 Pentose phosphate pathway (hexose monophosphate shunt) 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-72200 mRNA Editing: C to U Conversion 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-1296052 Ca2+ activated K+ channels 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-112411 MAPK1 (ERK2) activation 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-8854691 Interleukin-19, 20, 22, 24 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-166665 Terminal pathway of complement 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-198693 AKT phosphorylates targets in the nucleus 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2474795 Diseases associated with visual transduction 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2179392 EGFR Transactivation by Gastrin 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-162592 Integration of provirus 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-447041 CHL1 interactions 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-428890 Role of Abl in Robo-Slit signaling 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-74182 Ketone body metabolism 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-1614558 Degradation of cysteine and homocysteine 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-156587 Amino Acid conjugation 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-419771 Opsins 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-1300642 Sperm Motility And Taxes 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-196025 Formation of annular gap junctions 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-390696 Adrenoceptors 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-2243919 Crosslinking of collagen fibrils 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-163765 ChREBP activates metabolic gene expression 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-426486 Small interfering RNA (siRNA) biogenesis 0.999999999993007 -6.99277703178506e-12 9 0 0 32 10285 R-HSA-69275 G2/M Transition 0.999999999993287 -6.71331088693103e-12 182 0 0 32 10285 R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-5603029 IkBA variant leads to EDA-ID 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-199920 CREB phosphorylation 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-171319 Telomere Extension By Telomerase 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-448706 Interleukin-1 processing 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-162791 Attachment of GPI anchor to uPAR 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-196791 Vitamin D (calciferol) metabolism 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-6814848 Glycerophospholipid catabolism 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-182218 Nef Mediated CD8 Down-regulation 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-433692 Proton-coupled monocarboxylate transport 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-196843 Vitamin B2 (riboflavin) metabolism 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-420597 Nectin/Necl trans heterodimerization 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-5619102 SLC transporter disorders 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-429593 Inositol transporters 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-174362 Transport and synthesis of PAPS 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-111471 Apoptotic factor-mediated response 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3595177 Defective CHSY1 causes TPBS 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3656225 Defective CHST6 causes MCDC1 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-5652084 Fructose metabolism 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-190371 FGFR3b ligand binding and activation 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-447038 NrCAM interactions 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-164843 2-LTR circle formation 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-174577 Activation of C3 and C5 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3595172 Defective CHST3 causes SEDCJD 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-75158 TRAIL signaling 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-426117 Cation-coupled Chloride cotransporters 0.999999999993294 -6.7063060694105e-12 7 0 0 32 10285 R-HSA-190704 Oligomerization of connexins into connexons 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5624958 ARL13B-mediated ciliary trafficking of INPP5E 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-110331 Cleavage of the damaged purine 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-844615 The AIM2 inflammasome 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5250989 Toxicity of botulinum toxin type G (BoNT/G) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5250971 Toxicity of botulinum toxin type C (BoNT/C) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-3359462 Defective AMN causes hereditary megaloblastic anemia 1 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-350864 Regulation of thyroid hormone activity 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-1368071 NR1D1 (REV-ERBA) represses gene expression 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5602680 MyD88 deficiency (TLR5) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-165181 Inhibition of TSC complex formation by PKB 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-217271 FMO oxidises nucleophiles 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-190827 Transport of connexins along the secretory pathway 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-191647 c-src mediated regulation of Cx43 function and closure of gap junctions 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-8849472 PTK6 Down-Regulation 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-3296197 Hydroxycarboxylic acid-binding receptors 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-163282 Mitochondrial transcription initiation 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-379397 Enzymatic degradation of dopamine by COMT 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-198745 Signalling to STAT3 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5602571 TRAF3 deficiency - HSE 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-111446 Activation of BIM and translocation to mitochondria 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-139910 Activation of BMF and translocation to mitochondria 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-351200 Interconversion of polyamines 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-177539 Autointegration results in viral DNA circles 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-162699 Synthesis of dolichyl-phosphate mannose 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-3304347 Loss of Function of SMAD4 in Cancer 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-844455 The NLRP1 inflammasome 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-1307965 betaKlotho-mediated ligand binding 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-352238 Breakdown of the nuclear lamina 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-193681 Ceramide signalling 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-190374 FGFR1c and Klotho ligand binding and activation 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-3359463 Defective CUBN causes hereditary megaloblastic anemia 1 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-191650 Regulation of gap junction activity 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-8853336 Signaling by plasma membrane FGFR1 fusions 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-265473 Trafficking of dietary sterols 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-977442 GABA A (rho) receptor activation 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-1296067 Potassium transport channels 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-6806664 Metabolism of vitamin K 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-427589 Type II Na+/Pi cotransporters 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5250992 Toxicity of botulinum toxin type E (BoNT/E) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5357572 Lysosomal glycogen catabolism 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-2395516 Electron transport from NADPH to Ferredoxin 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5339700 TCF7L2 mutants don't bind CTBP 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-111458 Formation of apoptosome 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-379398 Enzymatic degradation of Dopamine by monoamine oxidase 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-444411 Rhesus glycoproteins mediate ammonium transport. 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-8875791 MET activates STAT3 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-175567 Integration of viral DNA into host genomic DNA 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5627083 RHO GTPases regulate CFTR trafficking 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-1483248 Synthesis of PIPs at the ER membrane 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-1299503 TWIK related potassium channel (TREK) 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-3249367 STAT6-mediated induction of chemokines 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-380615 Serotonin clearance from the synaptic cleft 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-73927 Depurination 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-77108 Utilization of Ketone Bodies 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-5653890 Lactose synthesis 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate 0.999999999993441 -6.55921125642906e-12 3 0 0 32 10285 R-HSA-72172 mRNA Splicing 0.999999999993466 -6.53436017108731e-12 195 0 0 32 10285 R-HSA-168276 NS1 Mediated Effects on Host Pathways 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-167290 Pausing and recovery of HIV elongation 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-5675221 Negative regulation of MAPK pathway 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-167287 HIV elongation arrest and recovery 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-1442490 Collagen degradation 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-5654741 Signaling by FGFR3 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-109703 PKB-mediated events 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 0.999999999993584 -6.41638560995574e-12 40 0 0 32 10285 R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-168325 Viral Messenger RNA Synthesis 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-5655253 Signaling by FGFR2 in disease 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-5696395 Formation of Incision Complex in GG-NER 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-375280 Amine ligand-binding receptors 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-5362517 Signaling by Retinoic Acid 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-194068 Bile acid and bile salt metabolism 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-75893 TNF signaling 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.999999999993802 -6.19847159358625e-12 43 0 0 32 10285 R-HSA-2132295 MHC class II antigen presentation 0.999999999993942 -6.05785984865078e-12 103 0 0 32 10285 R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.999999999993942 -6.05785984865078e-12 103 0 0 32 10285 R-HSA-202403 TCR signaling 0.999999999993968 -6.03170804644868e-12 119 0 0 32 10285 R-HSA-69206 G1/S Transition 0.999999999993968 -6.03170804644868e-12 119 0 0 32 10285 R-HSA-162587 HIV Life Cycle 0.999999999993993 -6.00720322695639e-12 152 0 0 32 10285 R-HSA-5357801 Programmed Cell Death 0.999999999994012 -5.9882356758544e-12 175 0 0 32 10285 R-HSA-5655302 Signaling by FGFR1 in disease 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-156590 Glutathione conjugation 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-76009 Platelet Aggregation (Plug Formation) 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-5689901 Metalloprotease DUBs 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-5685938 HDR through Single Strand Annealing (SSA) 0.999999999994066 -5.93452217436147e-12 38 0 0 32 10285 R-HSA-622323 Presynaptic nicotinic acetylcholine receptors 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-4641265 Repression of WNT target genes 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-211979 Eicosanoids 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-210990 PECAM1 interactions 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-844456 The NLRP3 inflammasome 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-1839130 Signaling by activated point mutants of FGFR3 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-176974 Unwinding of DNA 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-390666 Serotonin receptors 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-1296346 Tandem pore domain potassium channels 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-879518 Transport of organic anions 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-203615 eNOS activation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-211958 Miscellaneous substrates 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-2160916 Hyaluronan uptake and degradation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-209822 Glycoprotein hormones 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-1236977 Endosomal/Vacuolar pathway 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-71064 Lysine catabolism 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-190373 FGFR1c ligand binding and activation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-5578768 Physiological factors 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-2033514 FGFR3 mutant receptor activation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-5689877 Josephin domain DUBs 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-71384 Ethanol oxidation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-2022857 Keratan sulfate degradation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-8866427 VLDLR internalisation and degradation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-3371511 HSF1 activation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-166786 Creation of C4 and C2 activators 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-417957 P2Y receptors 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-451308 Activation of Ca-permeable Kainate Receptor 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-451306 Ionotropic activity of Kainate Receptors 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-389359 CD28 dependent Vav1 pathway 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-1433617 Regulation of signaling by NODAL 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-1475029 Reversible hydration of carbon dioxide 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-8851680 Butyrophilin (BTN) family interactions 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-73621 Pyrimidine catabolism 0.999999999994475 -5.5253139461288e-12 12 0 0 32 10285 R-HSA-5688426 Deubiquitination 0.999999999994648 -5.35168974140597e-12 301 0 0 32 10285 R-HSA-109581 Apoptosis 0.999999999994735 -5.26508057115668e-12 172 0 0 32 10285 R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.999999999994736 -5.26355046445411e-12 100 0 0 32 10285 R-HSA-75105 Fatty Acyl-CoA Biosynthesis 0.999999999994787 -5.21350159661925e-12 55 0 0 32 10285 R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.999999999994787 -5.21350159661925e-12 55 0 0 32 10285 R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.999999999994787 -5.21350159661925e-12 55 0 0 32 10285 R-HSA-5617833 Cilium Assembly 0.999999999995035 -4.96483562237421e-12 192 0 0 32 10285 R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.999999999995327 -4.67271132086027e-12 73 0 0 32 10285 R-HSA-421837 Clathrin derived vesicle budding 0.999999999995327 -4.67271132086027e-12 73 0 0 32 10285 R-HSA-199992 trans-Golgi Network Vesicle Budding 0.999999999995327 -4.67271132086027e-12 73 0 0 32 10285 R-HSA-3214841 PKMTs methylate histone lysines 0.999999999995327 -4.67271132086027e-12 73 0 0 32 10285 R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.999999999995327 -4.67271132086027e-12 73 0 0 32 10285 R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.999999999995327 -4.67271132086027e-12 73 0 0 32 10285 R-HSA-427413 NoRC negatively regulates rRNA expression 0.9999999999954 -4.59993524497239e-12 107 0 0 32 10285 R-HSA-382556 ABC-family proteins mediated transport 0.9999999999954 -4.59993524497239e-12 107 0 0 32 10285 R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 0.9999999999954 -4.59993524497239e-12 107 0 0 32 10285 R-HSA-199977 ER to Golgi Anterograde Transport 0.999999999995493 -4.50653554534721e-12 133 0 0 32 10285 R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-392517 Rap1 signalling 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-5213460 RIPK1-mediated regulated necrosis 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-418038 Nucleotide-like (purinergic) receptors 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-918233 TRAF3-dependent IRF activation pathway 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-159418 Recycling of bile acids and salts 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-163210 Formation of ATP by chemiosmotic coupling 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-549132 Organic cation/anion/zwitterion transport 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-1295596 Spry regulation of FGF signaling 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-5218859 Regulated Necrosis 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-1170546 Prolactin receptor signaling 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-446353 Cell-extracellular matrix interactions 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-110312 Translesion synthesis by REV1 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-399956 CRMPs in Sema3A signaling 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-1433559 Regulation of KIT signaling 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-5686938 Regulation of TLR by endogenous ligand 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-190242 FGFR1 ligand binding and activation 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-1834941 STING mediated induction of host immune responses 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.999999999995804 -4.19621520263653e-12 16 0 0 32 10285 R-HSA-6798695 Neutrophil degranulation 0.999999999995879 -4.1210675883199e-12 487 0 0 32 10285 R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.999999999996113 -3.8865264170468e-12 64 0 0 32 10285 R-HSA-8873719 RAB geranylgeranylation 0.999999999996113 -3.8865264170468e-12 64 0 0 32 10285 R-HSA-69242 S Phase 0.999999999996629 -3.37106019801233e-12 130 0 0 32 10285 R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.999999999997331 -2.66877645353663e-12 93 0 0 32 10285 R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.999999999997331 -2.66877645353663e-12 93 0 0 32 10285 R-HSA-1474290 Collagen formation 0.999999999997331 -2.66877645353663e-12 93 0 0 32 10285 R-HSA-68877 Mitotic Prometaphase 0.999999999997351 -2.64918749988094e-12 111 0 0 32 10285 R-HSA-1474228 Degradation of the extracellular matrix 0.999999999997351 -2.64918749988094e-12 111 0 0 32 10285 R-HSA-6785807 Interleukin-4 and 13 signaling 0.999999999997351 -2.64918749988094e-12 111 0 0 32 10285 R-HSA-2467813 Separation of Sister Chromatids 0.999999999997427 -2.57330878694376e-12 168 0 0 32 10285 R-HSA-1474165 Reproduction 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-73848 Pyrimidine metabolism 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-975298 Ligand-gated ion channel transport 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-1187000 Fertilization 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-3238698 WNT ligand biogenesis and trafficking 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-379716 Cytosolic tRNA aminoacylation 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-912694 Regulation of IFNA signaling 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-210991 Basigin interactions 0.999999999997517 -2.48297094717817e-12 26 0 0 32 10285 R-HSA-73857 RNA Polymerase II Transcription 0.999999999997525 -2.475089896153e-12 159 0 0 32 10285 R-HSA-69481 G2/M Checkpoints 0.999999999997687 -2.3131173643631e-12 169 0 0 32 10285 R-HSA-8856688 Golgi-to-ER retrograde transport 0.999999999997789 -2.2109238474502e-12 110 0 0 32 10285 R-HSA-2990846 SUMOylation 0.999999999997789 -2.2109238474502e-12 110 0 0 32 10285 R-HSA-5250941 Negative epigenetic regulation of rRNA expression 0.999999999997789 -2.2109238474502e-12 110 0 0 32 10285 R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.999999999997789 -2.2109238474502e-12 110 0 0 32 10285 R-HSA-73854 RNA Polymerase I Promoter Clearance 0.999999999997789 -2.2109238474502e-12 110 0 0 32 10285 R-HSA-199991 Membrane Trafficking 0.999999999998324 -1.6758809507459e-12 610 0 0 32 10285 R-HSA-1852241 Organelle biogenesis and maintenance 0.999999999998366 -1.63358052825796e-12 340 0 0 32 10285 R-HSA-1482925 Acyl chain remodelling of PG 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-5654704 SHC-mediated cascade:FGFR3 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-5654710 PI-3K cascade:FGFR3 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-73780 RNA Polymerase III Chain Elongation 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-5635838 Activation of SMO 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-209776 Amine-derived hormones 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-196757 Metabolism of folate and pterines 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-210993 Tie2 Signaling 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-1369062 ABC transporters in lipid homeostasis 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-69205 G1/S-Specific Transcription 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-181429 Serotonin Neurotransmitter Release Cycle 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-418457 cGMP effects 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-912631 Regulation of signaling by CBL 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-197264 Nicotinamide salvaging 0.999999999998634 -1.36639625549858e-12 18 0 0 32 10285 R-HSA-425410 Metal ion SLC transporters 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-1614635 Sulfur amino acid metabolism 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-5673000 RAF activation 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-933542 TRAF6 mediated NF-kB activation 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-182971 EGFR downregulation 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-3000157 Laminin interactions 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-429947 Deadenylation of mRNA 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-977068 Termination of O-glycan biosynthesis 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-211981 Xenobiotics 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-203927 MicroRNA (miRNA) biogenesis 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-1296059 G protein gated Potassium channels 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-162588 Budding and maturation of HIV virion 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-1296041 Activation of G protein gated Potassium channels 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-982772 Growth hormone receptor signaling 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-1538133 G0 and Early G1 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-499943 Synthesis and interconversion of nucleotide di- and triphosphates 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-5654700 FRS-mediated FGFR2 signaling 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-5654708 Downstream signaling of activated FGFR3 0.999999999998779 -1.22136907262989e-12 25 0 0 32 10285 R-HSA-202733 Cell surface interactions at the vascular wall 0.999999999999005 -9.95429370587889e-13 136 0 0 32 10285 R-HSA-5653656 Vesicle-mediated transport 0.999999999999123 -8.77222969814178e-13 650 0 0 32 10285 R-HSA-72163 mRNA Splicing - Major Pathway 1.0000000000007 6.95218450281952e-13 187 0 0 32 10285 R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-72165 mRNA Splicing - Minor Pathway 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-194441 Metabolism of non-coding RNA 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-75153 Apoptotic execution phase 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-180534 Vpu mediated degradation of CD4 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-191859 snRNP Assembly 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 1.00000000000093 9.30500986738967e-13 53 0 0 32 10285 R-HSA-73923 Lipid digestion, mobilization, and transport 1.00000000000141 1.4133718412491e-12 115 0 0 32 10285 R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 1.00000000000141 1.4133718412491e-12 115 0 0 32 10285 R-HSA-3214842 HDMs demethylate histones 1.00000000000171 1.71297326536639e-12 52 0 0 32 10285 R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 1.00000000000171 1.71297326536639e-12 52 0 0 32 10285 R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1 1.00000000000171 1.71297326536639e-12 52 0 0 32 10285 R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 1.00000000000171 1.71297326536639e-12 52 0 0 32 10285 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 1.00000000000171 1.71297326536639e-12 52 0 0 32 10285 R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 1.00000000000171 1.71297326536639e-12 52 0 0 32 10285 R-HSA-3247509 Chromatin modifying enzymes 1.00000000000182 1.82135347098646e-12 279 0 0 32 10285 R-HSA-4839726 Chromatin organization 1.00000000000182 1.82135347098646e-12 279 0 0 32 10285 R-HSA-6782135 Dual incision in TC-NER 1.00000000000323 3.23366015783799e-12 66 0 0 32 10285 R-HSA-452723 Transcriptional regulation of pluripotent stem cells 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-936440 Negative regulators of RIG-I/MDA5 signaling 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-6806003 Regulation of TP53 Expression and Degradation 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-177243 Interactions of Rev with host cellular proteins 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-445355 Smooth Muscle Contraction 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-2514856 The phototransduction cascade 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-176033 Interactions of Vpr with host cellular proteins 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-76046 RNA Polymerase III Transcription Initiation 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-432720 Lysosome Vesicle Biogenesis 1.00000000000347 3.47265097445781e-12 36 0 0 32 10285 R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 1.00000000000496 4.95994818824359e-12 126 0 0 32 10285 R-HSA-5619507 Activation of HOX genes during differentiation 1.00000000000496 4.95994818824359e-12 126 0 0 32 10285 R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 1.00000000000572 5.71731048022017e-12 99 0 0 32 10285 R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.00000000000572 5.71731048022017e-12 99 0 0 32 10285 R-HSA-162909 Host Interactions of HIV factors 1.00000000000608 6.08292739698262e-12 134 0 0 32 10285 R-HSA-69306 DNA Replication 1.00000000000681 6.8138296250214e-12 109 0 0 32 10285 R-HSA-72306 tRNA processing 1.00000000000681 6.8138296250214e-12 109 0 0 32 10285 R-HSA-211945 Phase 1 - Functionalization of compounds 1.00000000000681 6.8138296250214e-12 109 0 0 32 10285 R-HSA-73886 Chromosome Maintenance 1.00000000000681 6.8138296250214e-12 109 0 0 32 10285 R-HSA-156580 Phase II conjugation 1.00000000000801 8.01260481603339e-12 106 0 0 32 10285 R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-73776 RNA Polymerase II Promoter Escape 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-167162 RNA Polymerase II HIV Promoter Escape 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-8948216 Collagen chain trimerization 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-167161 HIV Transcription Initiation 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-75953 RNA Polymerase II Transcription Initiation 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-5576892 Phase 0 - rapid depolarisation 1.00000000001041 1.04094287547991e-11 47 0 0 32 10285 R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1.00000000001367 1.36709271328454e-11 63 0 0 32 10285 R-HSA-73728 RNA Polymerase I Promoter Opening 1.00000000001367 1.36709271328454e-11 63 0 0 32 10285 R-HSA-1226099 Signaling by FGFR in disease 1.00000000001367 1.36709271328454e-11 63 0 0 32 10285