TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols R-HSA-192823 Viral mRNA Translation 2.17421933253124e-19 -42.972447094348 92 14 0.341463414634146 41 10285 6234,6232,6158,6143,6176,6209,23521,6157,6233,6137,11224,6122,6141,6168 RPS28,RPS27,RPL28,RPL19,RPLP1,RPS15,RPL13A,RPL27A,RPS27A,RPL13,RPL35,RPL3,RPL18,RPL37A R-HSA-156902 Peptide chain elongation 2.17421933253124e-19 -42.972447094348 92 14 0.341463414634146 41 10285 23521,6157,6233,6137,11224,6122,6168,6141,6234,6232,6158,6143,6176,6209 RPL13A,RPL27A,RPS27A,RPL13,RPL35,RPL3,RPL37A,RPL18,RPS28,RPS27,RPL28,RPL19,RPLP1,RPS15 R-HSA-2408557 Selenocysteine synthesis 3.50118204603184e-19 -42.4960161279709 95 14 0.341463414634146 41 10285 6232,6234,6176,6209,6158,6143,6137,11224,23521,6157,6233,6122,6168,6141 RPS27,RPS28,RPLP1,RPS15,RPL28,RPL19,RPL13,RPL35,RPL13A,RPL27A,RPS27A,RPL3,RPL37A,RPL18 R-HSA-72764 Eukaryotic Translation Termination 4.08882236700986e-19 -42.3408597681183 96 14 0.341463414634146 41 10285 6209,6176,6143,6158,6232,6234,6141,6168,6122,11224,6137,6233,6157,23521 RPS15,RPLP1,RPL19,RPL28,RPS27,RPS28,RPL18,RPL37A,RPL3,RPL35,RPL13,RPS27A,RPL27A,RPL13A R-HSA-156842 Eukaryotic Translation Elongation 4.08882236700986e-19 -42.3408597681183 96 14 0.341463414634146 41 10285 6232,6234,6209,6176,6158,6143,11224,6137,6157,6233,23521,6141,6168,6122 RPS27,RPS28,RPS15,RPLP1,RPL28,RPL19,RPL35,RPL13,RPL27A,RPS27A,RPL13A,RPL18,RPL37A,RPL3 R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6.44514861673374e-19 -41.8857890715321 99 14 0.341463414634146 41 10285 6209,6176,6158,6143,6232,6234,6141,6168,6122,11224,6137,6157,6233,23521 RPS15,RPLP1,RPL28,RPL19,RPS27,RPS28,RPL18,RPL37A,RPL3,RPL35,RPL13,RPL27A,RPS27A,RPL13A R-HSA-72689 Formation of a pool of free 40S subunits 1.53318198989903e-18 -41.019186366177 105 14 0.341463414634146 41 10285 6232,6234,6209,6176,6143,6158,11224,6137,6233,6157,23521,6141,6168,6122 RPS27,RPS28,RPS15,RPLP1,RPL19,RPL28,RPL35,RPL13,RPS27A,RPL27A,RPL13A,RPL18,RPL37A,RPL3 R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.80296216150172e-18 -39.6881631692119 115 14 0.341463414634146 41 10285 6122,6141,6168,6137,11224,23521,6233,6157,6176,6209,6143,6158,6232,6234 RPL3,RPL18,RPL37A,RPL13,RPL35,RPL13A,RPS27A,RPL27A,RPLP1,RPS15,RPL19,RPL28,RPS27,RPS28 R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 7.45941871174138e-18 -39.4370541833912 117 14 0.341463414634146 41 10285 6234,6232,6158,6143,6209,6176,6157,6233,23521,11224,6137,6141,6168,6122 RPS28,RPS27,RPL28,RPL19,RPS15,RPLP1,RPL27A,RPS27A,RPL13A,RPL35,RPL13,RPL18,RPL37A,RPL3 R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 7.45941871174138e-18 -39.4370541833912 117 14 0.341463414634146 41 10285 6234,6232,6143,6158,6176,6209,23521,6233,6157,6137,11224,6122,6141,6168 RPS28,RPS27,RPL19,RPL28,RPLP1,RPS15,RPL13A,RPS27A,RPL27A,RPL13,RPL35,RPL3,RPL18,RPL37A R-HSA-927802 Nonsense-Mediated Decay (NMD) 1.07785225728491e-17 -39.0689761704159 120 14 0.341463414634146 41 10285 6158,6143,6176,6209,6234,6232,6122,6141,6168,23521,6157,6233,6137,11224 RPL28,RPL19,RPLP1,RPS15,RPS28,RPS27,RPL3,RPL18,RPL37A,RPL13A,RPL27A,RPS27A,RPL13,RPL35 R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.07785225728491e-17 -39.0689761704159 120 14 0.341463414634146 41 10285 6234,6232,6158,6143,6209,6176,6157,6233,23521,11224,6137,6168,6141,6122 RPS28,RPS27,RPL28,RPL19,RPS15,RPLP1,RPL27A,RPS27A,RPL13A,RPL35,RPL13,RPL37A,RPL18,RPL3 R-HSA-2408522 Selenoamino acid metabolism 1.21586353721978e-17 -38.9484920263333 121 14 0.341463414634146 41 10285 6232,6234,6176,6209,6158,6143,6137,11224,23521,6157,6233,6122,6168,6141 RPS27,RPS28,RPLP1,RPS15,RPL28,RPL19,RPL13,RPL35,RPL13A,RPL27A,RPS27A,RPL3,RPL37A,RPL18 R-HSA-72613 Eukaryotic Translation Initiation 1.94809762046855e-17 -38.4770932637572 125 14 0.341463414634146 41 10285 6209,6141,6168,6122,6176,6158,6143,11224,6232,6137,6234,6157,6233,23521 RPS15,RPL18,RPL37A,RPL3,RPLP1,RPL28,RPL19,RPL35,RPS27,RPL13,RPS28,RPL27A,RPS27A,RPL13A R-HSA-72737 Cap-dependent Translation Initiation 1.94809762046855e-17 -38.4770932637572 125 14 0.341463414634146 41 10285 6233,6157,6234,23521,6232,11224,6137,6143,6158,6141,6168,6209,6176,6122 RPS27A,RPL27A,RPS28,RPL13A,RPS27,RPL35,RPL13,RPL19,RPL28,RPL18,RPL37A,RPS15,RPLP1,RPL3 R-HSA-168273 Influenza Viral RNA Transcription and Replication 7.30796633937824e-17 -37.15498154839 137 14 0.341463414634146 41 10285 6122,6141,6168,6137,11224,23521,6233,6157,6176,6209,6143,6158,6232,6234 RPL3,RPL18,RPL37A,RPL13,RPL35,RPL13A,RPS27A,RPL27A,RPLP1,RPS15,RPL19,RPL28,RPS27,RPS28 R-HSA-168255 Influenza Life Cycle 1.81949448004425e-16 -36.2428027836154 146 14 0.341463414634146 41 10285 6176,6209,6158,6143,6232,6234,6122,6141,6168,6137,11224,23521,6157,6233 RPLP1,RPS15,RPL28,RPL19,RPS27,RPS28,RPL3,RPL18,RPL37A,RPL13,RPL35,RPL13A,RPL27A,RPS27A R-HSA-168254 Influenza Infection 5.12761403989164e-16 -35.2067210363507 157 14 0.341463414634146 41 10285 6234,6232,6158,6143,6209,6176,6157,6233,23521,11224,6137,6141,6168,6122 RPS28,RPS27,RPL28,RPL19,RPS15,RPLP1,RPL27A,RPS27A,RPL13A,RPL35,RPL13,RPL18,RPL37A,RPL3 R-HSA-72766 Translation 8.00518020101989e-16 -34.7612726306513 162 14 0.341463414634146 41 10285 6232,6234,6176,6209,6158,6143,6137,11224,23521,6157,6233,6122,6141,6168 RPS27,RPS28,RPLP1,RPS15,RPL28,RPL19,RPL13,RPL35,RPL13A,RPL27A,RPS27A,RPL3,RPL18,RPL37A R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 3.28254373094376e-15 -33.3501577453541 179 14 0.341463414634146 41 10285 6143,6158,6209,6176,6234,6232,6168,6141,6122,6233,6157,23521,11224,6137 RPL19,RPL28,RPS15,RPLP1,RPS28,RPS27,RPL37A,RPL18,RPL3,RPS27A,RPL27A,RPL13A,RPL35,RPL13 R-HSA-8868773 rRNA processing in the nucleus and cytosol 8.17226108794431e-15 -32.438030769378 191 14 0.341463414634146 41 10285 6234,6232,6143,6158,6176,6209,23521,6233,6157,6137,11224,6122,6168,6141 RPS28,RPS27,RPL19,RPL28,RPLP1,RPS15,RPL13A,RPS27A,RPL27A,RPL13,RPL35,RPL3,RPL37A,RPL18 R-HSA-72312 rRNA processing 1.66950387218599e-14 -31.7236648021491 201 14 0.341463414634146 41 10285 23521,6233,6234,6157,6137,6232,11224,6143,6158,6176,6122,6141,6168,6209 RPL13A,RPS27A,RPS28,RPL27A,RPL13,RPS27,RPL35,RPL19,RPL28,RPLP1,RPL3,RPL18,RPL37A,RPS15 R-HSA-71291 Metabolism of amino acids and derivatives 4.99862661632038e-11 -23.7192728249669 361 14 0.341463414634146 41 10285 6234,6157,6233,23521,11224,6232,6137,6158,6143,6209,6141,6168,6122,6176 RPS28,RPL27A,RPS27A,RPL13A,RPL35,RPS27,RPL13,RPL28,RPL19,RPS15,RPL18,RPL37A,RPL3,RPLP1 R-HSA-5663205 Infectious disease 1.30481027396428e-10 -22.7597932836705 388 14 0.341463414634146 41 10285 6209,6141,6168,6122,6176,6158,6143,11224,6232,6137,6157,6234,6233,23521 RPS15,RPL18,RPL37A,RPL3,RPLP1,RPL28,RPL19,RPL35,RPS27,RPL13,RPL27A,RPS28,RPS27A,RPL13A R-HSA-1643685 Disease 8.742104904651e-09 -18.5551148405028 858 17 0.414634146341463 41 10285 23521,6157,6233,6137,11224,4854,3164,6122,6168,6141,6234,6232,3725,6158,6143,6176,6209 RPL13A,RPL27A,RPS27A,RPL13,RPL35,NOTCH3,NR4A1,RPL3,RPL37A,RPL18,RPS28,RPS27,JUN,RPL28,RPL19,RPLP1,RPS15 R-HSA-74160 Gene Expression 1.03189787152631e-06 -13.7841108575012 1821 21 0.51219512195122 41 10285 3164,6141,6168,3315,6122,6233,6157,23521,4854,11224,6137,60,6143,3726,3725,6158,6209,6176,6234,7538,6232 NR4A1,RPL18,RPL37A,HSPB1,RPL3,RPS27A,RPL27A,RPL13A,NOTCH3,RPL35,RPL13,ACTB,RPL19,JUNB,JUN,RPL28,RPS15,RPLP1,RPS28,ZFP36,RPS27 R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 5.52637257375965e-05 -9.80339381878019 53 4 0.0975609756097561 41 10285 6234,6233,6209,6232 RPS28,RPS27A,RPS15,RPS27 R-HSA-1430728 Metabolism 6.8017327083431e-05 -9.59574807519628 2158 20 0.48780487804878 41 10285 4502,6168,6141,6122,2597,682,11224,6137,5243,6157,6233,23521,4493,6209,6176,6158,6143,6232,6234,2 MT2A,RPL37A,RPL18,RPL3,GAPDH,BSG,RPL35,RPL13,ABCB1,RPL27A,RPS27A,RPL13A,MT1E,RPS15,RPLP1,RPL28,RPL19,RPS27,RPS28,A2M R-HSA-72702 Ribosomal scanning and start codon recognition 9.6246878591051e-05 -9.2485940155451 61 4 0.0975609756097561 41 10285 6234,6233,6209,6232 RPS28,RPS27A,RPS15,RPS27 R-HSA-72649 Translation initiation complex formation 0.000102589096581053 -9.18477890201462 62 4 0.0975609756097561 41 10285 6234,6233,6209,6232 RPS28,RPS27A,RPS15,RPS27 R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.000109229678742646 -9.12205774822231 63 4 0.0975609756097561 41 10285 6233,6234,6232,6209 RPS27A,RPS28,RPS27,RPS15 R-HSA-5660526 Response to metal ions 0.000833593933286576 -7.08976416471889 11 2 0.0487804878048781 41 10285 4493,4502 MT1E,MT2A R-HSA-5661231 Metallothioneins bind metals 0.000833593933286576 -7.08976416471889 11 2 0.0487804878048781 41 10285 4493,4502 MT1E,MT2A R-HSA-392499 Metabolism of proteins 0.000918849398710698 -6.99238832421637 1619 15 0.365853658536585 41 10285 11224,6137,6157,6233,23521,6141,6168,6122,6232,6234,6209,6176,60,6158,6143 RPL35,RPL13,RPL27A,RPS27A,RPL13A,RPL18,RPL37A,RPL3,RPS27,RPS28,RPS15,RPLP1,ACTB,RPL28,RPL19 R-HSA-5625900 RHO GTPases activate CIT 0.0020302640433777 -6.19958942375748 17 2 0.0487804878048781 41 10285 10398,388 MYL9,RHOB R-HSA-5627117 RHO GTPases Activate ROCKs 0.0020302640433777 -6.19958942375748 17 2 0.0487804878048781 41 10285 388,10398 RHOB,MYL9 R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 0.0040481863005958 -5.50948632518154 24 2 0.0487804878048781 41 10285 10398,388 MYL9,RHOB R-HSA-210991 Basigin interactions 0.00474294441855901 -5.35109715078091 26 2 0.0487804878048781 41 10285 682,483 BSG,ATP1B3 R-HSA-400685 Sema4D in semaphorin signaling 0.00510950509023082 -5.27665273068375 27 2 0.0487804878048781 41 10285 388,10398 RHOB,MYL9 R-HSA-5687128 MAPK6/MAPK4 signaling 0.00543274217377153 -5.21531126813028 90 3 0.0731707317073171 41 10285 6233,3725,3315 RPS27A,JUN,HSPB1 R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.00560253328362852 -5.18453641145391 91 3 0.0731707317073171 41 10285 3315,7538,6233 HSPB1,ZFP36,RPS27A R-HSA-1912408 Pre-NOTCH Transcription and Translation 0.0062846886440532 -5.06963897769717 30 2 0.0487804878048781 41 10285 3725,4854 JUN,NOTCH3 R-HSA-194315 Signaling by Rho GTPases 0.00640246778378706 -5.05107177172097 426 6 0.146341463414634 41 10285 10395,6232,10398,2,60,388 DLC1,RPS27,MYL9,A2M,ACTB,RHOB R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 0.00802401307400429 -4.82531659896138 34 2 0.0487804878048781 41 10285 6233,3726 RPS27A,JUNB R-HSA-913531 Interferon Signaling 0.00814921606261057 -4.80983354499253 201 4 0.0975609756097561 41 10285 4502,3429,10410,6233 MT2A,IFI27,IFITM3,RPS27A R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 0.00944730474984291 -4.6620257898139 110 3 0.0731707317073171 41 10285 3725,3490,6233 JUN,IGFBP7,RPS27A R-HSA-157118 Signaling by NOTCH 0.00992243156034882 -4.61295727075096 112 3 0.0731707317073171 41 10285 4854,6233,3725 NOTCH3,RPS27A,JUN R-HSA-5696394 DNA Damage Recognition in GG-NER 0.0104663689495762 -4.55958811944859 39 2 0.0487804878048781 41 10285 6233,60 RPS27A,ACTB R-HSA-5675221 Negative regulation of MAPK pathway 0.0109896303163211 -4.51080314931973 40 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-5663220 RHO GTPases Activate Formins 0.0111706231039594 -4.49446788375416 117 3 0.0731707317073171 41 10285 6232,60,388 RPS27,ACTB,RHOB R-HSA-1234162 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha 0.0119127070249663 -4.43014963135187 3 1 0.024390243902439 41 10285 2034 EPAS1 R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer 0.0143647672742965 -4.24297678756646 46 2 0.0487804878048781 41 10285 6233,3726 RPS27A,JUNB R-HSA-1912422 Pre-NOTCH Expression and Processing 0.0149656831832693 -4.20199548664671 47 2 0.0487804878048781 41 10285 4854,3725 NOTCH3,JUN R-HSA-114608 Platelet degranulation 0.0154419232386071 -4.17066918005677 132 3 0.0731707317073171 41 10285 7114,7078,2 TMSB4X,TIMP3,A2M R-HSA-5083630 Defective LFNG causes SCDO3 0.0158527555576652 -4.14441194155077 4 1 0.024390243902439 41 10285 4854 NOTCH3 R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.017044055243715 -4.07195380210853 137 3 0.0731707317073171 41 10285 7114,7078,2 TMSB4X,TIMP3,A2M R-HSA-194840 Rho GTPase cycle 0.0187363948471603 -3.97728739809818 142 3 0.0731707317073171 41 10285 10395,388,2 DLC1,RHOB,A2M R-HSA-2161517 Abacavir transmembrane transport 0.0197774746530865 -3.92321163267306 5 1 0.024390243902439 41 10285 5243 ABCB1 R-HSA-8849473 PTK6 Expression 0.0197774746530865 -3.92321163267306 5 1 0.024390243902439 41 10285 2034 EPAS1 R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.0215499038277983 -3.83738392518952 57 2 0.0487804878048781 41 10285 6233,3315 RPS27A,HSPB1 R-HSA-76002 Platelet activation, signaling and aggregation 0.0252900680771284 -3.67734352644432 282 4 0.0975609756097561 41 10285 7114,7078,2,388 TMSB4X,TIMP3,A2M,RHOB R-HSA-450294 MAP kinase activation in TLR cascade 0.0267497035621831 -3.62123188748907 64 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 0.0275811569440956 -3.59062245883489 7 1 0.024390243902439 41 10285 4854 NOTCH3 R-HSA-433692 Proton-coupled monocarboxylate transport 0.0275811569440956 -3.59062245883489 7 1 0.024390243902439 41 10285 682 BSG R-HSA-5683057 MAPK family signaling cascades 0.0276658329178613 -3.58755709580672 290 4 0.0975609756097561 41 10285 6233,1843,3725,3315 RPS27A,DUSP1,JUN,HSPB1 R-HSA-195258 RHO GTPase Effectors 0.0289026164575442 -3.54382315309866 294 4 0.0975609756097561 41 10285 6232,388,60,10398 RPS27,RHOB,ACTB,MYL9 R-HSA-8848021 Signaling by PTK6 0.029118646529405 -3.53637653580647 67 2 0.0487804878048781 41 10285 2034,6233 EPAS1,RPS27A R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.029118646529405 -3.53637653580647 67 2 0.0487804878048781 41 10285 2034,6233 EPAS1,RPS27A R-HSA-373755 Semaphorin interactions 0.0299264177224516 -3.50901365280561 68 2 0.0487804878048781 41 10285 10398,388 MYL9,RHOB R-HSA-909733 Interferon alpha/beta signaling 0.0307431157826156 -3.48208918678191 69 2 0.0487804878048781 41 10285 10410,3429 IFITM3,IFI27 R-HSA-1253288 Downregulation of ERBB4 signaling 0.031460235808318 -3.45903088588366 8 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 0.0353242165741754 -3.34318652831705 9 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-198693 AKT phosphorylates targets in the nucleus 0.0353242165741754 -3.34318652831705 9 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins 0.0353242165741754 -3.34318652831705 9 1 0.024390243902439 41 10285 388 RHOB R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 0.0353242165741754 -3.34318652831705 9 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-170834 Signaling by TGF-beta Receptor Complex 0.0375885380239558 -3.28105611484779 77 2 0.0487804878048781 41 10285 6233,3726 RPS27A,JUNB R-HSA-2262749 Cellular response to hypoxia 0.0375885380239558 -3.28105611484779 77 2 0.0487804878048781 41 10285 6233,2034 RPS27A,EPAS1 R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen 0.0375885380239558 -3.28105611484779 77 2 0.0487804878048781 41 10285 2034,6233 EPAS1,RPS27A R-HSA-109582 Hemostasis 0.0377109283847758 -3.2778053489543 632 6 0.146341463414634 41 10285 388,2,7114,483,7078,682 RHOB,A2M,TMSB4X,ATP1B3,TIMP3,BSG R-HSA-937042 IRAK2 mediated activation of TAK1 complex 0.0391731565430771 -3.23976354882041 10 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3785653 Myoclonic epilepsy of Lafora 0.0391731565430771 -3.23976354882041 10 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-390450 Folding of actin by CCT/TriC 0.0391731565430771 -3.23976354882041 10 1 0.024390243902439 41 10285 60 ACTB R-HSA-5663084 Diseases of carbohydrate metabolism 0.0391731565430771 -3.23976354882041 10 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-450341 Activation of the AP-1 family of transcription factors 0.0391731565430771 -3.23976354882041 10 1 0.024390243902439 41 10285 3725 JUN R-HSA-3229121 Glycogen storage diseases 0.0391731565430771 -3.23976354882041 10 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2161522 Abacavir transport and metabolism 0.0391731565430771 -3.23976354882041 10 1 0.024390243902439 41 10285 5243 ABCB1 R-HSA-70326 Glucose metabolism 0.041211050382686 -3.18904884541739 81 2 0.0487804878048781 41 10285 2597,6233 GAPDH,RPS27A R-HSA-2559583 Cellular Senescence 0.0427926019287487 -3.15139004346708 196 3 0.0731707317073171 41 10285 3725,3490,6233 JUN,IGFBP7,RPS27A R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins 0.0430071128029555 -3.14638976294574 11 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-174490 Membrane binding and targetting of GAG proteins 0.0430071128029555 -3.14638976294574 11 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1980148 Signaling by NOTCH3 0.0430071128029555 -3.14638976294574 11 1 0.024390243902439 41 10285 4854 NOTCH3 R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade 0.0440113589560828 -3.12330752028815 84 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-975871 MyD88 cascade initiated on plasma membrane 0.0440113589560828 -3.12330752028815 84 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade 0.0440113589560828 -3.12330752028815 84 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER) 0.0449602898212833 -3.10197562721456 85 2 0.0487804878048781 41 10285 6233,60 RPS27A,ACTB R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 0.0468261422350209 -3.06131363724911 12 1 0.024390243902439 41 10285 2034 EPAS1 R-HSA-5689877 Josephin domain DUBs 0.0468261422350209 -3.06131363724911 12 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 0.050630301503131 -2.9832050379888 13 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-175474 Assembly Of The HIV Virion 0.050630301503131 -2.9832050379888 13 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-350054 Notch-HLH transcription pathway 0.050630301503131 -2.9832050379888 13 1 0.024390243902439 41 10285 4854 NOTCH3 R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 0.0508114830207162 -2.97963290622685 91 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-975155 MyD88 dependent cascade initiated on endosome 0.0528202090926965 -2.9408614135315 93 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade 0.0528202090926965 -2.9408614135315 93 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-5625740 RHO GTPases activate PKNs 0.0528202090926965 -2.9408614135315 93 2 0.0487804878048781 41 10285 388,10398 RHOB,MYL9 R-HSA-209560 NF-kB is activated and signals survival 0.0544196470676377 -2.911030030991 14 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-209543 p75NTR recruits signalling complexes 0.0544196470676377 -2.911030030991 14 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2682334 EPH-Ephrin signaling 0.0548571633291178 -2.90302250226275 95 2 0.0487804878048781 41 10285 10398,60 MYL9,ACTB R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.0548571633291178 -2.90302250226275 95 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.0548571633291178 -2.90302250226275 95 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane 0.0548571633291178 -2.90302250226275 95 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.0548571633291178 -2.90302250226275 95 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 0.0569217941846365 -2.86607698509359 97 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-3322077 Glycogen synthesis 0.0581942351778399 -2.84396898107786 15 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 0.0581942351778399 -2.84396898107786 15 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69298 Association of licensing factors with the pre-replicative complex 0.0581942351778399 -2.84396898107786 15 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-205043 NRIF signals cell death from the nucleus 0.0581942351778399 -2.84396898107786 15 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer 0.0581942351778399 -2.84396898107786 15 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 0.0581942351778399 -2.84396898107786 15 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 0.0581942351778399 -2.84396898107786 15 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1266738 Developmental Biology 0.0587863136921167 -2.8338462115086 1075 8 0.195121951219512 41 10285 1843,3725,388,60,10398,6233,2034,10974 DUSP1,JUN,RHOB,ACTB,MYL9,RPS27A,EPAS1,ADIRF R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 0.0590135567139066 -2.82998808665863 99 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling 0.0590135567139066 -2.82998808665863 99 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-166166 MyD88-independent TLR3/TLR4 cascade 0.0590135567139066 -2.82998808665863 99 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.0596799396535714 -2.81875933425384 372 4 0.0975609756097561 41 10285 3725,3164,1843,6233 JUN,NR4A1,DUSP1,RPS27A R-HSA-110312 Translesion synthesis by REV1 0.0619541218721176 -2.78136113765439 16 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 0.0619541218721176 -2.78136113765439 16 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1295596 Spry regulation of FGF signaling 0.0619541218721176 -2.78136113765439 16 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 0.0619541218721176 -2.78136113765439 16 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5689603 UCH proteinases 0.0654462826373421 -2.72652558522408 105 2 0.0487804878048781 41 10285 60,6233 ACTB,RPS27A R-HSA-422475 Axon guidance 0.0655248438295061 -2.72532591314817 549 5 0.121951219512195 41 10285 10398,1843,6233,388,60 MYL9,DUSP1,RPS27A,RHOB,ACTB R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 0.0656993629878064 -2.72266604931017 17 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-937072 TRAF6 mediated induction of TAK1 complex 0.0656993629878064 -2.72266604931017 17 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5655862 Translesion synthesis by POLK 0.0656993629878064 -2.72266604931017 17 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5656121 Translesion synthesis by POLI 0.0656993629878064 -2.72266604931017 17 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-193639 p75NTR signals via NF-kB 0.0656993629878064 -2.72266604931017 17 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-382556 ABC-family proteins mediated transport 0.0676412522806539 -2.69353724121637 107 2 0.0487804878048781 41 10285 6233,5243 RPS27A,ABCB1 R-HSA-1912420 Pre-NOTCH Processing in Golgi 0.0694300141494345 -2.66743602442273 18 1 0.024390243902439 41 10285 4854 NOTCH3 R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 0.0694300141494345 -2.66743602442273 18 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 0.0694300141494345 -2.66743602442273 18 1 0.024390243902439 41 10285 7538 ZFP36 R-HSA-1474228 Degradation of the extracellular matrix 0.072104196239827 -2.62964303610981 111 2 0.0487804878048781 41 10285 682,2 BSG,A2M R-HSA-110320 Translesion Synthesis by POLH 0.0731461307753572 -2.61529604730516 19 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5696398 Nucleotide Excision Repair 0.0732347737795292 -2.61408491918326 112 2 0.0487804878048781 41 10285 60,6233 ACTB,RPS27A R-HSA-166054 Activated TLR4 signalling 0.0766611327290358 -2.56836044312747 115 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 0.0768477680867133 -2.56592885188234 20 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1643713 Signaling by EGFR in Cancer 0.0768477680867133 -2.56592885188234 20 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 0.0768477680867133 -2.56592885188234 20 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-6804760 Regulation of TP53 Activity through Methylation 0.0768477680867133 -2.56592885188234 20 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-194223 HDL-mediated lipid transport 0.0768477680867133 -2.56592885188234 20 1 0.024390243902439 41 10285 2 A2M R-HSA-8876384 Listeria monocytogenes entry into host cells 0.0768477680867133 -2.56592885188234 20 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1280215 Cytokine Signaling in Immune system 0.0771288772117582 -2.56227752623076 756 6 0.146341463414634 41 10285 10410,6233,1843,3726,4502,3429 IFITM3,RPS27A,DUSP1,JUNB,MT2A,IFI27 R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.0805349810942961 -2.51906364119092 21 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-6807004 Negative regulation of MET activity 0.0805349810942961 -2.51906364119092 21 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3000480 Scavenging by Class A Receptors 0.0805349810942961 -2.51906364119092 21 1 0.024390243902439 41 10285 2512 FTL R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 0.0842078246021432 -2.47446743328492 22 1 0.024390243902439 41 10285 2 A2M R-HSA-4641263 Regulation of FZD by ubiquitination 0.0842078246021432 -2.47446743328492 22 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-901032 ER Quality Control Compartment (ERQC) 0.0842078246021432 -2.47446743328492 22 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8863678 Neurodegenerative Diseases 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 3725 JUN R-HSA-5205685 Pink/Parkin Mediated Mitophagy 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5205647 Mitophagy 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-112409 RAF-independent MAPK1/3 activation 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 1843 DUSP1 R-HSA-5627123 RHO GTPases activate PAKs 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 10398 MYL9 R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 3725 JUN R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 0.0878663532174168 -2.43193833235659 23 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2871796 FCERI mediated MAPK activation 0.0881714539832286 -2.42847201933948 265 3 0.0731707317073171 41 10285 6233,1843,3725 RPS27A,DUSP1,JUN R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.0896456021537829 -2.41189113586452 126 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-2559580 Oxidative Stress Induced Senescence 0.0896456021537829 -2.41189113586452 126 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-937041 IKK complex recruitment mediated by RIP1 0.0915106213437063 -2.39130023317837 24 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 0.0951406831856939 -2.35239860715773 25 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-182971 EGFR downregulation 0.0951406831856939 -2.35239860715773 25 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 0.0951406831856939 -2.35239860715773 25 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 0.0951406831856939 -2.35239860715773 25 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-162588 Budding and maturation of HIV virion 0.0951406831856939 -2.35239860715773 25 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-202733 Cell surface interactions at the vascular wall 0.101975218987573 -2.2830254463175 136 2 0.0487804878048781 41 10285 483,682 ATP1B3,BSG R-HSA-901042 Calnexin/calreticulin cycle 0.102358403796378 -2.27927486182955 27 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2173788 Downregulation of TGF-beta receptor signaling 0.102358403796378 -2.27927486182955 27 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2262752 Cellular responses to stress 0.103581024109573 -2.26740113089902 451 4 0.0975609756097561 41 10285 3490,3725,2034,6233 IGFBP7,JUN,EPAS1,RPS27A R-HSA-70268 Pyruvate metabolism 0.105946169973571 -2.24482414429763 28 1 0.024390243902439 41 10285 682 BSG R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 0.105946169973571 -2.24482414429763 28 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 0.109519944667763 -2.21164860322702 29 1 0.024390243902439 41 10285 60 ACTB R-HSA-5654732 Negative regulation of FGFR3 signaling 0.109519944667763 -2.21164860322702 29 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 0.113079781083386 -2.17966168210321 30 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 0.113079781083386 -2.17966168210321 30 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8863795 Downregulation of ERBB2 signaling 0.113079781083386 -2.17966168210321 30 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 0.113079781083386 -2.17966168210321 30 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-420029 Tight junction interactions 0.113079781083386 -2.17966168210321 30 1 0.024390243902439 41 10285 7122 CLDN5 R-HSA-162582 Signal Transduction 0.114556897496108 -2.16668365804899 2547 14 0.341463414634146 41 10285 3726,3725,388,60,6232,10395,2,10398,2034,3315,3164,1843,4854,6233 JUNB,JUN,RHOB,ACTB,RPS27,DLC1,A2M,MYL9,EPAS1,HSPB1,NR4A1,DUSP1,NOTCH3,RPS27A R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases 0.11662573222715 -2.14878534135931 31 1 0.024390243902439 41 10285 3725 JUN R-HSA-5654733 Negative regulation of FGFR4 signaling 0.11662573222715 -2.14878534135931 31 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-70171 Glycolysis 0.12015785090925 -2.11894897636885 32 1 0.024390243902439 41 10285 2597 GAPDH R-HSA-70263 Gluconeogenesis 0.12015785090925 -2.11894897636885 32 1 0.024390243902439 41 10285 2597 GAPDH R-HSA-2559585 Oncogene Induced Senescence 0.12015785090925 -2.11894897636885 32 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5357905 Regulation of TNFR1 signaling 0.123676189748891 -2.09008850195191 33 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5654726 Negative regulation of FGFR1 signaling 0.123676189748891 -2.09008850195191 33 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1980145 Signaling by NOTCH2 0.123676189748891 -2.09008850195191 33 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-168898 Toll-Like Receptors Cascades 0.123925975724311 -2.08807086159985 153 2 0.0487804878048781 41 10285 6233,3725 RPS27A,JUN R-HSA-5654727 Negative regulation of FGFR2 signaling 0.127180801162606 -2.06214557372408 34 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5656169 Termination of translesion DNA synthesis 0.127180801162606 -2.06214557372408 34 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2173789 TGF-beta receptor signaling activates SMADs 0.127180801162606 -2.06214557372408 34 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3928663 EPHA-mediated growth cone collapse 0.127180801162606 -2.06214557372408 34 1 0.024390243902439 41 10285 10398 MYL9 R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.127180801162606 -2.06214557372408 34 1 0.024390243902439 41 10285 60 ACTB R-HSA-382551 Transmembrane transport of small molecules 0.129774668526087 -2.0419556514922 677 5 0.121951219512195 41 10285 6233,5243,2512,483,682 RPS27A,ABCB1,FTL,ATP1B3,BSG R-HSA-6804757 Regulation of TP53 Degradation 0.130671737379673 -2.03506692213564 35 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 0.134149050432688 -2.0088037805352 36 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 0.134149050432688 -2.0088037805352 36 1 0.024390243902439 41 10285 60 ACTB R-HSA-6806003 Regulation of TP53 Expression and Degradation 0.134149050432688 -2.0088037805352 36 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-936440 Negative regulators of RIG-I/MDA5 signaling 0.134149050432688 -2.0088037805352 36 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-452723 Transcriptional regulation of pluripotent stem cells 0.134149050432688 -2.0088037805352 36 1 0.024390243902439 41 10285 2034 EPAS1 R-HSA-445355 Smooth Muscle Contraction 0.134149050432688 -2.0088037805352 36 1 0.024390243902439 41 10285 10398 MYL9 R-HSA-5689896 Ovarian tumor domain proteases 0.137612792152592 -1.98331139157875 37 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5689901 Metalloprotease DUBs 0.141063014200687 -1.95854857921342 38 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.143499930302164 -1.94142072948178 330 3 0.0731707317073171 41 10285 1843,6233,3315 DUSP1,RPS27A,HSPB1 R-HSA-2467813 Separation of Sister Chromatids 0.144161709272778 -1.93681962841675 168 2 0.0487804878048781 41 10285 6233,6232 RPS27A,RPS27 R-HSA-6783310 Fanconi Anemia Pathway 0.144499768021978 -1.93447737681518 39 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69231 Cyclin D associated events in G1 0.144499768021978 -1.93447737681518 39 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69236 G1 Phase 0.144499768021978 -1.93447737681518 39 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-140877 Formation of Fibrin Clot (Clotting Cascade) 0.144499768021978 -1.93447737681518 39 1 0.024390243902439 41 10285 2 A2M R-HSA-5654741 Signaling by FGFR3 0.147923104888299 -1.91106270180245 40 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1433557 Signaling by SCF-KIT 0.150047157362984 -1.89680565187378 337 3 0.0731707317073171 41 10285 6233,3164,1843 RPS27A,NR4A1,DUSP1 R-HSA-194138 Signaling by VEGF 0.150990589410451 -1.89053776589439 338 3 0.0731707317073171 41 10285 1843,6233,3315 DUSP1,RPS27A,HSPB1 R-HSA-5696400 Dual Incision in GG-NER 0.151333075865626 -1.88827207093881 41 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5654743 Signaling by FGFR4 0.151333075865626 -1.88827207093881 41 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 0.151333075865626 -1.88827207093881 41 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 0.154729731849725 -1.86607534950264 42 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3928662 EPHB-mediated forward signaling 0.154729731849725 -1.86607534950264 42 1 0.024390243902439 41 10285 60 ACTB R-HSA-5696395 Formation of Incision Complex in GG-NER 0.158113123530449 -1.84444453042894 43 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.158113123530449 -1.84444453042894 43 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.158113123530449 -1.84444453042894 43 1 0.024390243902439 41 10285 2512 FTL R-HSA-1236394 Signaling by ERBB4 0.158113123530449 -1.84444453042894 43 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-75893 TNF signaling 0.158113123530449 -1.84444453042894 43 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-68882 Mitotic Anaphase 0.159423793280641 -1.83618925600724 179 2 0.0487804878048781 41 10285 6233,6232 RPS27A,RPS27 R-HSA-2555396 Mitotic Metaphase and Anaphase 0.160826673687454 -1.82742805485314 180 2 0.0487804878048781 41 10285 6233,6232 RPS27A,RPS27 R-HSA-5668914 Diseases of metabolism 0.161483301419666 -1.8233535384475 44 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-917937 Iron uptake and transport 0.161483301419666 -1.8233535384475 44 1 0.024390243902439 41 10285 2512 FTL R-HSA-186763 Downstream signal transduction 0.164401772167374 -1.80544201681126 352 3 0.0731707317073171 41 10285 6233,3164,1843 RPS27A,NR4A1,DUSP1 R-HSA-446652 Interleukin-1 signaling 0.168184216916037 -1.78269537106585 46 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2424491 DAP12 signaling 0.168300269264043 -1.78200557788147 356 3 0.0731707317073171 41 10285 3164,1843,6233 NR4A1,DUSP1,RPS27A R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 0.174832878667634 -1.74392474038372 48 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-177929 Signaling by EGFR 0.176180931501389 -1.73624379210031 364 3 0.0731707317073171 41 10285 6233,1843,3164 RPS27A,DUSP1,NR4A1 R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 0.178137738682448 -1.72519821510609 49 1 0.024390243902439 41 10285 682 BSG R-HSA-5654736 Signaling by FGFR1 0.181429684045462 -1.70688711606957 50 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-73893 DNA Damage Bypass 0.181429684045462 -1.70688711606957 50 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-73887 Death Receptor Signalling 0.181429684045462 -1.70688711606957 50 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2172127 DAP12 interactions 0.18316380178948 -1.69737443475066 371 3 0.0731707317073171 41 10285 6233,1843,3164 RPS27A,DUSP1,NR4A1 R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.184708763962813 -1.68897494318519 51 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1227986 Signaling by ERBB2 0.184708763962813 -1.68897494318519 51 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-383280 Nuclear Receptor transcription pathway 0.184708763962813 -1.68897494318519 51 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.185009959801984 -1.68734561858548 197 2 0.0487804878048781 41 10285 6233,3164 RPS27A,NR4A1 R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.18797502746459 -1.67144615761038 52 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.18797502746459 -1.67144615761038 52 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69229 Ubiquitin-dependent degradation of Cyclin D1 0.18797502746459 -1.67144615761038 52 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-186797 Signaling by PDGF 0.188198919737256 -1.67025579181941 376 3 0.0731707317073171 41 10285 1843,3164,6233 DUSP1,NR4A1,RPS27A R-HSA-180534 Vpu mediated degradation of CD4 0.191228523399203 -1.65428610853303 53 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.191228523399203 -1.65428610853303 53 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-114604 GPVI-mediated activation cascade 0.194469300424022 -1.63748096681834 54 1 0.024390243902439 41 10285 388 RHOB R-HSA-169911 Regulation of Apoptosis 0.194469300424022 -1.63748096681834 54 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 0.194469300424022 -1.63748096681834 54 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.194469300424022 -1.63748096681834 54 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 0.194469300424022 -1.63748096681834 54 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69610 p53-Independent DNA Damage Response 0.194469300424022 -1.63748096681834 54 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-397014 Muscle contraction 0.195125112919753 -1.63411432144202 204 2 0.0487804878048781 41 10285 483,10398 ATP1B3,MYL9 R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.19769740703275 -1.62101766455799 55 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-187037 NGF signalling via TRKA from the plasma membrane 0.199406622216727 -1.61240921129008 387 3 0.0731707317073171 41 10285 3164,1843,6233 NR4A1,DUSP1,RPS27A R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.200912891516685 -1.60488384039626 56 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.200912891516685 -1.60488384039626 56 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5578775 Ion homeostasis 0.200912891516685 -1.60488384039626 56 1 0.024390243902439 41 10285 483 ATP1B3 R-HSA-69541 Stabilization of p53 0.200912891516685 -1.60488384039626 56 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-4641257 Degradation of AXIN 0.200912891516685 -1.60488384039626 56 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-983712 Ion channel transport 0.202396089216264 -1.59752866380953 209 2 0.0487804878048781 41 10285 483,6233 ATP1B3,RPS27A R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.204115802009915 -1.58906778928281 57 1 0.024390243902439 41 10285 2512 FTL R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 0.207306186457284 -1.57355841696937 58 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2644603 Signaling by NOTCH1 in Cancer 0.207306186457284 -1.57355841696937 58 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-936837 Ion transport by P-type ATPases 0.207306186457284 -1.57355841696937 58 1 0.024390243902439 41 10285 483 ATP1B3 R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 0.207306186457284 -1.57355841696937 58 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 0.207306186457284 -1.57355841696937 58 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 0.207306186457284 -1.57355841696937 58 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 0.207306186457284 -1.57355841696937 58 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.210484092617941 -1.55834519822619 59 1 0.024390243902439 41 10285 4854 NOTCH3 R-HSA-4641258 Degradation of DVL 0.210484092617941 -1.55834519822619 59 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.213649568095918 -1.54341813844379 60 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5387390 Hh mutants abrogate ligand secretion 0.213649568095918 -1.54341813844379 60 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 0.213649568095918 -1.54341813844379 60 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5610780 Degradation of GLI1 by the proteasome 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-421270 Cell-cell junction organization 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 7122 CLDN5 R-HSA-5610783 Degradation of GLI2 by the proteasome 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 60 ACTB R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.21680266029453 -1.52876773876071 61 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.219943416450021 -1.51438496366529 62 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8852135 Protein ubiquitination 0.219943416450021 -1.51438496366529 62 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.226188108707209 -1.48638828649978 64 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.229292138400513 -1.47275837491967 65 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.229292138400513 -1.47275837491967 65 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 0.229292138400513 -1.47275837491967 65 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.231774990286714 -1.46198824739735 229 2 0.0487804878048781 41 10285 6233,3164 RPS27A,NR4A1 R-HSA-6782135 Dual incision in TC-NER 0.232384019256362 -1.45936402032586 66 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-4608870 Asymmetric localization of PCP proteins 0.235463797626466 -1.44619810292029 67 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69615 G1/S DNA Damage Checkpoints 0.235463797626466 -1.44619810292029 67 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5358346 Hedgehog ligand biogenesis 0.235463797626466 -1.44619810292029 67 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.238531519720874 -1.43325381922706 68 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-216083 Integrin cell surface interactions 0.238531519720874 -1.43325381922706 68 1 0.024390243902439 41 10285 682 BSG R-HSA-5685942 HDR through Homologous Recombination (HRR) 0.238531519720874 -1.43325381922706 68 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1169091 Activation of NF-kappaB in B cells 0.238531519720874 -1.43325381922706 68 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.238531519720874 -1.43325381922706 68 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5619084 ABC transporter disorders 0.241587231534598 -1.42052466392652 69 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-68867 Assembly of the pre-replicative complex 0.241587231534598 -1.42052466392652 69 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 0.241587231534598 -1.42052466392652 69 1 0.024390243902439 41 10285 3725 JUN R-HSA-6806834 Signaling by MET 0.241587231534598 -1.42052466392652 69 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5658442 Regulation of RAS by GAPs 0.244630978944377 -1.40800441229988 70 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-400253 Circadian Clock 0.247662807616233 -1.39568710468417 71 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.247662807616233 -1.39568710468417 71 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69202 Cyclin E associated events during G1/S transition 0.250682763057653 -1.38356703143632 72 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-68949 Orc1 removal from chromatin 0.250682763057653 -1.38356703143632 72 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69052 Switching of origins to a post-replicative state 0.250682763057653 -1.38356703143632 72 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.253690890614542 -1.37163871915263 73 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-421837 Clathrin derived vesicle budding 0.253690890614542 -1.37163871915263 73 1 0.024390243902439 41 10285 2512 FTL R-HSA-1980143 Signaling by NOTCH1 0.253690890614542 -1.37163871915263 73 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.253690890614542 -1.37163871915263 73 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-199992 trans-Golgi Network Vesicle Budding 0.253690890614542 -1.37163871915263 73 1 0.024390243902439 41 10285 2512 FTL R-HSA-112412 SOS-mediated signalling 0.255499564971771 -1.36453457199434 245 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-5673001 RAF/MAP kinase cascade 0.255499564971771 -1.36453457199434 245 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-180336 SHC1 events in EGFR signaling 0.255499564971771 -1.36453457199434 245 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-179812 GRB2 events in EGFR signaling 0.255499564971771 -1.36453457199434 245 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-69300 Removal of licensing factors from origins 0.256687235454174 -1.35989691788026 74 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-174824 Lipoprotein metabolism 0.256687235454174 -1.35989691788026 74 1 0.024390243902439 41 10285 2 A2M R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.256687235454174 -1.35989691788026 74 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 0.259671842569885 -1.34833658910312 75 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5654738 Signaling by FGFR2 0.259671842569885 -1.34833658910312 75 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-212436 Generic Transcription Pathway 0.259792272201663 -1.34787292037024 865 5 0.121951219512195 41 10285 3725,3164,3726,6233,4854 JUN,NR4A1,JUNB,RPS27A,NOTCH3 R-HSA-187706 Signalling to p38 via RIT and RIN 0.26144667037068 -1.34152495367224 249 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-170984 ARMS-mediated activation 0.26144667037068 -1.34152495367224 249 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE 0.262644756819616 -1.33695289439472 76 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.262644756819616 -1.33695289439472 76 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1169408 ISG15 antiviral mechanism 0.262644756819616 -1.33695289439472 76 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5619115 Disorders of transmembrane transporters 0.262644756819616 -1.33695289439472 76 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.262644756819616 -1.33695289439472 76 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5693606 DNA Double Strand Break Response 0.262644756819616 -1.33695289439472 76 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-170968 Frs2-mediated activation 0.262933994244021 -1.33585225075942 250 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-5684996 MAPK1/MAPK3 signaling 0.264421487753645 -1.33021090443676 251 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.265606022863581 -1.32574118519276 77 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69304 Regulation of DNA replication 0.265606022863581 -1.32574118519276 77 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-169893 Prolonged ERK activation events 0.265909126546063 -1.32460065809518 252 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-2586552 Signaling by Leptin 0.267396886442781 -1.31902125820115 253 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-912526 Interleukin receptor SHC signaling 0.270372673720889 -1.30795399864463 255 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 0.271493788146065 -1.30381601962656 79 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2871837 FCERI mediated NF-kB activation 0.271493788146065 -1.30381601962656 79 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-167044 Signalling to RAS 0.271860653638845 -1.30246564675642 256 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-5218921 VEGFR2 mediated cell proliferation 0.274836668756074 -1.29157828955902 258 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.277335492477304 -1.28252734148445 81 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-451927 Interleukin-2 signaling 0.280788274202436 -1.27015436624073 262 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-187687 Signalling to ERKs 0.282275954568212 -1.26487012422536 263 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.283131487250746 -1.26184386998042 83 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 0.286012452652237 -1.25171992836807 84 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1236974 ER-Phagosome pathway 0.288882121257985 -1.24173655899785 85 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3781865 Diseases of glycosylation 0.288882121257985 -1.24173655899785 85 1 0.024390243902439 41 10285 4854 NOTCH3 R-HSA-69002 DNA Replication Pre-Initiation 0.291740536254272 -1.23189044620184 86 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.291740536254272 -1.23189044620184 86 1 0.024390243902439 41 10285 60 ACTB R-HSA-68874 M/G1 Transition 0.291740536254272 -1.23189044620184 86 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5632684 Hedgehog 'on' state 0.291740536254272 -1.23189044620184 86 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8853659 RET signaling 0.292684764810135 -1.22865913716806 270 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling 0.294170771424819 -1.22359482508807 271 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.29458774069316 -1.22217838921675 87 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-453276 Regulation of mitotic cell cycle 0.29458774069316 -1.22217838921675 87 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-166520 Signalling by NGF 0.295913728419457 -1.2176873251826 477 3 0.0731707317073171 41 10285 6233,1843,3164 RPS27A,DUSP1,NR4A1 R-HSA-416482 G alpha (12/13) signalling events 0.297423777430556 -1.21259729714138 88 1 0.024390243902439 41 10285 388 RHOB R-HSA-446728 Cell junction organization 0.297423777430556 -1.21259729714138 88 1 0.024390243902439 41 10285 7122 CLDN5 R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 0.297423777430556 -1.21259729714138 88 1 0.024390243902439 41 10285 10974 ADIRF R-HSA-190236 Signaling by FGFR 0.300248689181539 -1.20314418378831 89 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-375165 NCAM signaling for neurite out-growth 0.301595816585831 -1.19866751368117 276 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-2219528 PI3K/AKT Signaling in Cancer 0.303062518500727 -1.19381616307066 90 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 0.303062518500727 -1.19381616307066 90 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 0.311437935028978 -1.1665552060995 93 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5250924 B-WICH complex positively regulates rRNA expression 0.311437935028978 -1.1665552060995 93 1 0.024390243902439 41 10285 60 ACTB R-HSA-877300 Interferon gamma signaling 0.314207856986542 -1.15770054715073 94 1 0.024390243902439 41 10285 4502 MT2A R-HSA-4086400 PCP/CE pathway 0.319715126434731 -1.14032490956979 96 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-168256 Immune System 0.320344282411368 -1.13835897899967 2101 10 0.24390243902439 41 10285 6233,10410,3429,2512,60,3726,3164,3725,1843,4502 RPS27A,IFITM3,IFI27,FTL,ACTB,JUNB,NR4A1,JUN,DUSP1,MT2A R-HSA-193704 p75 NTR receptor-mediated signalling 0.322452556983425 -1.13179926369698 97 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5693607 Processing of DNA double-strand break ends 0.325179239857423 -1.12337874142302 98 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-202424 Downstream TCR signaling 0.325179239857423 -1.12337874142302 98 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-390466 Chaperonin-mediated protein folding 0.327895216226916 -1.1150611843599 99 1 0.024390243902439 41 10285 60 ACTB R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 0.327895216226916 -1.1150611843599 99 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-112399 IRS-mediated signalling 0.328224434312447 -1.11405765363836 294 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-1474244 Extracellular matrix organization 0.331170232705505 -1.10512273760713 296 2 0.0487804878048781 41 10285 2,682 A2M,BSG R-HSA-71387 Metabolism of carbohydrates 0.331170232705505 -1.10512273760713 296 2 0.0487804878048781 41 10285 6233,2597 RPS27A,GAPDH R-HSA-74751 Insulin receptor signalling cascade 0.332641974879677 -1.10068851790209 297 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-1236975 Antigen processing-Cross presentation 0.333295213194225 -1.09872665562509 101 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-977225 Amyloid fiber formation 0.333295213194225 -1.09872665562509 101 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69239 Synthesis of DNA 0.333295213194225 -1.09872665562509 101 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.333295213194225 -1.09872665562509 101 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5610787 Hedgehog 'off' state 0.333295213194225 -1.09872665562509 101 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2428928 IRS-related events triggered by IGF1R 0.334112923057924 -1.0962762501582 298 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-2428924 IGF1R signaling cascade 0.334112923057924 -1.0962762501582 298 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 0.335583060423862 -1.09188578115806 299 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-5688426 Deubiquitination 0.338520836103941 -1.0831696343028 301 2 0.0487804878048781 41 10285 60,6233 ACTB,RPS27A R-HSA-2500257 Resolution of Sister Chromatid Cohesion 0.338652874030693 -1.08277966662848 103 1 0.024390243902439 41 10285 6232 RPS27 R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.341315929630428 -1.07494675076155 104 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2672351 Stimuli-sensing channels 0.341315929630428 -1.07494675076155 104 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-391251 Protein folding 0.343968522387904 -1.06720513048187 105 1 0.024390243902439 41 10285 60 ACTB R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.346610692395104 -1.05955305279648 106 1 0.024390243902439 41 10285 682 BSG R-HSA-68886 M Phase 0.348775103804914 -1.05332796620085 308 2 0.0487804878048781 41 10285 6232,6233 RPS27,RPS27A R-HSA-449147 Signaling by Interleukins 0.349068149183441 -1.0524881059758 525 3 0.0731707317073171 41 10285 3726,1843,6233 JUNB,DUSP1,RPS27A R-HSA-5250913 Positive epigenetic regulation of rRNA expression 0.351863923684873 -1.04451075856622 108 1 0.024390243902439 41 10285 60 ACTB R-HSA-69306 DNA Replication 0.354475064417288 -1.03711727563263 109 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-6785807 Interleukin-4 and 13 signaling 0.359666593441144 -1.02257780598487 111 1 0.024390243902439 41 10285 3726 JUNB R-HSA-68877 Mitotic Prometaphase 0.359666593441144 -1.02257780598487 111 1 0.024390243902439 41 10285 6232 RPS27 R-HSA-73894 DNA Repair 0.360435711096943 -1.02044167076238 316 2 0.0487804878048781 41 10285 6233,60 RPS27A,ACTB R-HSA-74752 Signaling by Insulin receptor 0.369135796273126 -0.996590691060974 322 2 0.0487804878048781 41 10285 6233,1843 RPS27A,DUSP1 R-HSA-73923 Lipid digestion, mobilization, and transport 0.369927738266649 -0.994447594399813 115 1 0.024390243902439 41 10285 2 A2M R-HSA-69206 G1/S Transition 0.380028399137455 -0.967509294481945 119 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-202403 TCR signaling 0.380028399137455 -0.967509294481945 119 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1257604 PIP3 activates AKT signaling 0.39488382844646 -0.929163662537265 125 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 0.397325734263731 -0.922998845383013 126 1 0.024390243902439 41 10285 3725 JUN R-HSA-5619507 Activation of HOX genes during differentiation 0.397325734263731 -0.922998845383013 126 1 0.024390243902439 41 10285 3725 JUN R-HSA-198203 PI3K/AKT activation 0.402180738549638 -0.910853693020001 128 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-180292 GAB1 signalosome 0.402180738549638 -0.910853693020001 128 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-168249 Innate Immune System 0.406751056315825 -0.899553935920596 1285 6 0.146341463414634 41 10285 2512,60,6233,3164,1843,3725 FTL,ACTB,RPS27A,NR4A1,DUSP1,JUN R-HSA-69242 S Phase 0.406997578470057 -0.898948043262262 130 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 0.409391778289671 -0.893082688297414 131 1 0.024390243902439 41 10285 3164 NR4A1 R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) 0.411776546573458 -0.887274439450235 132 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1500931 Cell-Cell communication 0.414151919530494 -0.881522417080818 133 1 0.024390243902439 41 10285 7122 CLDN5 R-HSA-162909 Host Interactions of HIV factors 0.416517933258957 -0.875825761257852 134 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-8856828 Clathrin-mediated endocytosis 0.423560177927555 -0.859059678343583 137 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5693538 Homology Directed Repair 0.425889112952262 -0.853576264830359 138 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5358351 Signaling by Hedgehog 0.425889112952262 -0.853576264830359 138 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-162599 Late Phase of HIV Life Cycle 0.428208867215481 -0.848144194924474 139 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3700989 Transcriptional Regulation by TP53 0.432855691409414 -0.837350882719229 367 2 0.0487804878048781 41 10285 3725,6233 JUN,RPS27A R-HSA-5576891 Cardiac conduction 0.435113397495493 -0.832148597967912 142 1 0.024390243902439 41 10285 483 ATP1B3 R-HSA-5663202 Diseases of signal transduction 0.435615694248507 -0.830994859535386 369 2 0.0487804878048781 41 10285 6233,3164 RPS27A,NR4A1 R-HSA-3214847 HATs acetylate histones 0.437396780198533 -0.82691453199534 143 1 0.024390243902439 41 10285 60 ACTB R-HSA-453279 Mitotic G1-G1/S phases 0.437396780198533 -0.82691453199534 143 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5621481 C-type lectin receptors (CLRs) 0.439671157243427 -0.821728201391247 144 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-3858494 Beta-catenin independent WNT signaling 0.450909165383308 -0.796489366896955 149 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-212165 Epigenetic regulation of gene expression 0.45534253129669 -0.786705327218363 151 1 0.024390243902439 41 10285 60 ACTB R-HSA-162587 HIV Life Cycle 0.457546099116555 -0.781877636246527 152 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 0.470586003306997 -0.753776545360259 158 1 0.024390243902439 41 10285 682 BSG R-HSA-5633007 Regulation of TP53 Activity 0.479108838716718 -0.735827486678976 162 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5693532 DNA Double-Strand Break Repair 0.489574310304065 -0.714219019944842 167 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69481 G2/M Checkpoints 0.49370281048871 -0.705821541028013 169 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-109581 Apoptosis 0.499834542864724 -0.693478149594707 172 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5357801 Programmed Cell Death 0.505893804048649 -0.681428505142822 175 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69275 G2/M Transition 0.519754922664738 -0.65439788107244 182 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-453274 Mitotic G2-G2/M phases 0.523645067320479 -0.646941176609738 184 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 0.532502757007745 -0.630167203932626 443 2 0.0487804878048781 41 10285 1843,6233 DUSP1,RPS27A R-HSA-69620 Cell Cycle Checkpoints 0.555493441726587 -0.587898476044894 201 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-5689880 Ub-specific processing proteases 0.593639706426371 -0.521482698486056 223 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-162906 HIV Infection 0.614659001348852 -0.486687634302055 236 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-69278 Cell Cycle, Mitotic 0.614733921312483 -0.486565753067273 514 2 0.0487804878048781 41 10285 6233,6232 RPS27A,RPS27 R-HSA-201681 TCF dependent signaling in response to WNT 0.617797131301236 -0.481595141918542 238 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-4839726 Chromatin organization 0.676900520580144 -0.390230958402804 279 1 0.024390243902439 41 10285 60 ACTB R-HSA-3247509 Chromatin modifying enzymes 0.676900520580144 -0.390230958402804 279 1 0.024390243902439 41 10285 60 ACTB R-HSA-446203 Asparagine N-linked glycosylation 0.683467364027753 -0.380576372271576 284 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-425407 SLC-mediated transmembrane transport 0.687344774556239 -0.37491925739776 287 1 0.024390243902439 41 10285 682 BSG R-HSA-199991 Membrane Trafficking 0.708315329403723 -0.344865903927146 610 2 0.0487804878048781 41 10285 6233,2512 RPS27A,FTL R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.716740007030426 -0.333042116373155 311 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1640170 Cell Cycle 0.717776962337759 -0.3315963956043 621 2 0.0487804878048781 41 10285 6233,6232 RPS27A,RPS27 R-HSA-5653656 Vesicle-mediated transport 0.741532941003631 -0.299035693571441 650 2 0.0487804878048781 41 10285 6233,2512 RPS27A,FTL R-HSA-195721 Signaling by Wnt 0.744489929148188 -0.295055953949984 336 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.780754643312011 -0.247494335591023 373 1 0.024390243902439 41 10285 6233 RPS27A R-HSA-1280218 Adaptive Immune System 0.844571785121772 -0.168925543242316 810 2 0.0487804878048781 41 10285 3164,6233 NR4A1,RPS27A R-HSA-6798695 Neutrophil degranulation 0.86368832941683 -0.146543305098374 487 1 0.024390243902439 41 10285 2512 FTL R-HSA-372790 Signaling by GPCR 0.905565038258848 -0.0991961784413882 1299 3 0.0731707317073171 41 10285 1843,388,6233 DUSP1,RHOB,RPS27A R-HSA-597592 Post-translational protein modification 0.927911848526488 -0.074818541519823 1034 2 0.0487804878048781 41 10285 6233,60 RPS27A,ACTB R-HSA-556833 Metabolism of lipids and lipoproteins 0.966056782522954 -0.0345326654174969 813 1 0.024390243902439 41 10285 2 A2M R-HSA-388396 GPCR downstream signaling 0.983218099163707 -0.0169243124744941 974 1 0.024390243902439 41 10285 388 RHOB R-HSA-3000484 Scavenging by Class F Receptors 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-8857538 PTK6 promotes HIF1A stabilization 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-6806942 MET Receptor Activation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-1482798 Acyl chain remodeling of CL 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-177135 Conjugation of benzoate with glycine 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-2187335 The retinoid cycle in cones (daylight vision) 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5624138 Trafficking of myristoylated proteins to the cilium 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-187015 Activation of TRKA receptors 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-3065679 SUMO is proteolytically processed 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5579029 Metabolic disorders of biological oxidation enzymes 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-388479 Vasopressin-like receptors 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-947581 Molybdenum cofactor biosynthesis 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-176417 Phosphorylation of Emi1 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5626978 TNFR1-mediated ceramide production 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-428808 Na+-dependent glucose transporters 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-111957 Cam-PDE 1 activation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-193144 Estrogen biosynthesis 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-6793080 rRNA modification in the mitochondrion 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-446199 Synthesis of Dolichyl-phosphate 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5690714 CD22 mediated BCR regulation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5693548 Sensing of DNA Double Strand Breaks 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-444257 RSK activation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5676934 Protein repair 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-442717 CREB phosphorylation through the activation of CaMKK 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-390247 Beta-oxidation of very long chain fatty acids 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-1237112 Methionine salvage pathway 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-205025 NADE modulates death signalling 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5674499 Negative feedback regulation of MAPK pathway 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-166662 Lectin pathway of complement activation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-3323169 Defects in biotin (Btn) metabolism 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-1566977 Fibronectin matrix formation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-68616 Assembly of the ORC complex at the origin of replication 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5660668 CLEC7A/inflammasome pathway 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-8849470 PTK6 Regulates Cell Cycle 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-2142700 Synthesis of Lipoxins (LX) 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-6787639 GDP-fucose biosynthesis 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-6798163 Choline catabolism 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-189483 Heme degradation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-6799990 Metal sequestration by antimicrobial proteins 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-500753 Pyrimidine biosynthesis 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5336415 Uptake and function of diphtheria toxin 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-8851907 MET activates PI3K/AKT signaling 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-173623 Classical antibody-mediated complement activation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-5339717 Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-193993 Mineralocorticoid biosynthesis 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-190370 FGFR1b ligand binding and activation 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-211916 Vitamins 0.999999999953853 -4.61468150341961e-11 6 0 0 41 10285 R-HSA-75072 mRNA Editing 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-1839122 Signaling by activated point mutants of FGFR1 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-5625970 RHO GTPases activate KTN1 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-5602498 MyD88 deficiency (TLR2/4) 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-211999 CYP2E1 reactions 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-2514853 Condensation of Prometaphase Chromosomes 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-2485179 Activation of the phototransduction cascade 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-1980150 Signaling by NOTCH4 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-71182 Phenylalanine and tyrosine catabolism 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-71288 Creatine metabolism 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-2470946 Cohesin Loading onto Chromatin 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-5218900 CASP8 activity is inhibited 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-8851805 MET activates RAS signaling 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-8875555 MET activates RAP1 and RAC1 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-2022923 Dermatan sulfate biosynthesis 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-174414 Processive synthesis on the C-strand of the telomere 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-189451 Heme biosynthesis 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-68689 CDC6 association with the ORC:origin complex 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-1059683 Interleukin-6 signaling 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-376172 DSCAM interactions 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-69416 Dimerization of procaspase-8 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-418889 Ligand-independent caspase activation via DCC 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-549127 Organic cation transport 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-196780 Biotin transport and metabolism 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-5655291 Signaling by FGFR4 in disease 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-73614 Pyrimidine salvage reactions 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-3296469 Defects in cobalamin (B12) metabolism 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-5603041 IRAK4 deficiency (TLR2/4) 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-3371378 Regulation by c-FLIP 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-193048 Androgen biosynthesis 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-446107 Type I hemidesmosome assembly 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-351906 Apoptotic cleavage of cell adhesion proteins 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-937039 IRAK1 recruits IKK complex 0.999999999969723 -3.02770746114832e-11 11 0 0 41 10285 R-HSA-381070 IRE1alpha activates chaperones 0.999999999970787 -2.92132890838388e-11 58 0 0 41 10285 R-HSA-6794361 Interactions of neurexins and neuroligins at synapses 0.999999999970787 -2.92132890838388e-11 58 0 0 41 10285 R-HSA-6805567 Keratinization 0.999999999974705 -2.52946867208117e-11 214 0 0 41 10285 R-HSA-69473 G2/M DNA damage checkpoint 0.999999999975739 -2.42606088908463e-11 95 0 0 41 10285 R-HSA-451306 Ionotropic activity of Kainate Receptors 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-176974 Unwinding of DNA 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-190373 FGFR1c ligand binding and activation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-3371511 HSF1 activation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-3656237 Defective EXT2 causes exostoses 2 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-211958 Miscellaneous substrates 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-390666 Serotonin receptors 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-1296346 Tandem pore domain potassium channels 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-210990 PECAM1 interactions 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-1839130 Signaling by activated point mutants of FGFR3 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-1236977 Endosomal/Vacuolar pathway 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-211979 Eicosanoids 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-71064 Lysine catabolism 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-2033514 FGFR3 mutant receptor activation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-73621 Pyrimidine catabolism 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-451308 Activation of Ca-permeable Kainate Receptor 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-2160916 Hyaluronan uptake and degradation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-5578768 Physiological factors 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-71384 Ethanol oxidation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-4641265 Repression of WNT target genes 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-417957 P2Y receptors 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-879518 Transport of organic anions 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-166786 Creation of C4 and C2 activators 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-2468052 Establishment of Sister Chromatid Cohesion 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-8851680 Butyrophilin (BTN) family interactions 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-622323 Presynaptic nicotinic acetylcholine receptors 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-209822 Glycoprotein hormones 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-844456 The NLRP3 inflammasome 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-2022857 Keratan sulfate degradation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-1433617 Regulation of signaling by NODAL 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-8866427 VLDLR internalisation and degradation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-389359 CD28 dependent Vav1 pathway 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-203615 eNOS activation 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-1475029 Reversible hydration of carbon dioxide 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 0.999999999975861 -2.41391791460753e-11 12 0 0 41 10285 R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.99999999997667 -2.33303733730437e-11 82 0 0 41 10285 R-HSA-5628897 TP53 Regulates Metabolic Genes 0.99999999997667 -2.33303733730437e-11 82 0 0 41 10285 R-HSA-75109 Triglyceride Biosynthesis 0.99999999997667 -2.33303733730437e-11 82 0 0 41 10285 R-HSA-380287 Centrosome maturation 0.99999999997667 -2.33303733730437e-11 82 0 0 41 10285 R-HSA-157579 Telomere Maintenance 0.99999999997667 -2.33303733730437e-11 82 0 0 41 10285 R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 0.99999999997667 -2.33303733730437e-11 82 0 0 41 10285 R-HSA-5654699 SHC-mediated cascade:FGFR2 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-428930 Thromboxane signalling through TP receptor 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-389948 PD-1 signaling 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-5654695 PI-3K cascade:FGFR2 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-392170 ADP signalling through P2Y purinoceptor 12 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-3371571 HSF1-dependent transactivation 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-389977 Post-chaperonin tubulin folding pathway 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-5654693 FRS-mediated FGFR1 signaling 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-5365859 RA biosynthesis pathway 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-379726 Mitochondrial tRNA aminoacylation 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-8855121 VLDL interactions 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-73980 RNA Polymerase III Transcription Termination 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-212676 Dopamine Neurotransmitter Release Cycle 0.999999999977462 -2.25376402232234e-11 23 0 0 41 10285 R-HSA-2142753 Arachidonic acid metabolism 0.999999999977717 -2.22830851565742e-11 59 0 0 41 10285 R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 0.999999999977985 -2.20150718076549e-11 76 0 0 41 10285 R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-977606 Regulation of Complement cascade 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-5654716 Downstream signaling of activated FGFR4 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-180024 DARPP-32 events 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-380994 ATF4 activates genes 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-1482788 Acyl chain remodelling of PC 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-77387 Insulin receptor recycling 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-6783589 Interleukin-6 family signaling 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-114508 Effects of PIP2 hydrolysis 0.999999999978006 -2.19940140475013e-11 27 0 0 41 10285 R-HSA-422356 Regulation of insulin secretion 0.999999999978187 -2.18129417637622e-11 80 0 0 41 10285 R-HSA-427359 SIRT1 negatively regulates rRNA Expression 0.99999999997838 -2.16198247988869e-11 69 0 0 41 10285 R-HSA-204005 COPII (Coat Protein 2) Mediated Vesicle Transport 0.99999999997838 -2.16198247988869e-11 69 0 0 41 10285 R-HSA-388841 Costimulation by the CD28 family 0.99999999997838 -2.16198247988869e-11 69 0 0 41 10285 R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 0.99999999997838 -2.16198247988869e-11 69 0 0 41 10285 R-HSA-1483206 Glycerophospholipid biosynthesis 0.999999999978501 -2.14989677162443e-11 129 0 0 41 10285 R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 0.999999999978542 -2.14577753985534e-11 92 0 0 41 10285 R-HSA-373080 Class B/2 (Secretin family receptors) 0.999999999978542 -2.14577753985534e-11 92 0 0 41 10285 R-HSA-381119 Unfolded Protein Response (UPR) 0.999999999978542 -2.14577753985534e-11 92 0 0 41 10285 R-HSA-611105 Respiratory electron transport 0.999999999978542 -2.14577753985534e-11 92 0 0 41 10285 R-HSA-174800 Chylomicron-mediated lipid transport 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-1266695 Interleukin-7 signaling 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-5357769 Caspase activation via extrinsic apoptotic signalling pathway 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-5621480 Dectin-2 family 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-437239 Recycling pathway of L1 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-111997 CaM pathway 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-354192 Integrin alphaIIb beta3 signaling 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-190828 Gap junction trafficking 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-111933 Calmodulin induced events 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-5576893 Phase 2 - plateau phase 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-1483191 Synthesis of PC 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-1368082 RORA activates gene expression 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-264876 Insulin processing 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-211976 Endogenous sterols 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-2022854 Keratan sulfate biosynthesis 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-6803529 FGFR2 alternative splicing 0.999999999978908 -2.1091713430816e-11 28 0 0 41 10285 R-HSA-190322 FGFR4 ligand binding and activation 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-629602 Activation of Nicotinic Acetylcholine Receptors 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-2024101 CS/DS degradation 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-209952 Peptide hormone biosynthesis 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-4839744 truncated APC mutants destabilize the destruction complex 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-419408 Lysosphingolipid and LPA receptors 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-428540 Activation of Rac 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-5675482 Regulation of necroptotic cell death 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-4839748 AMER1 mutants destabilize the destruction complex 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-174411 Polymerase switching on the C-strand of the telomere 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-177504 Retrograde neurotrophin signalling 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-1483213 Synthesis of PE 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-418885 DCC mediated attractive signaling 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-622327 Postsynaptic nicotinic acetylcholine receptors 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-4839735 AXIN mutants destabilize the destruction complex, activating WNT signaling 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-181431 Acetylcholine Binding And Downstream Events 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-5467337 APC truncation mutants have impaired AXIN binding 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-1250347 SHC1 events in ERBB4 signaling 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-418359 Reduction of cytosolic Ca++ levels 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-69109 Leading Strand Synthesis 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-428790 Facilitative Na+-independent glucose transporters 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-69091 Polymerase switching 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-69166 Removal of the Flap Intermediate 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-877312 Regulation of IFNG signaling 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-1679131 Trafficking and processing of endosomal TLR 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-162594 Early Phase of HIV Life Cycle 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-174403 Glutathione synthesis and recycling 0.999999999979181 -2.08187893113964e-11 14 0 0 41 10285 R-HSA-1592389 Activation of Matrix Metalloproteinases 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-168638 NOD1/2 Signaling Pathway 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-68962 Activation of the pre-replicative complex 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-399719 Trafficking of AMPA receptors 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-69190 DNA strand elongation 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-451326 Activation of Kainate Receptors upon glutamate binding 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-399721 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-376176 Signaling by Robo receptor 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-73863 RNA Polymerase I Transcription Termination 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-196071 Metabolism of steroid hormones 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-168274 Export of Viral Ribonucleoproteins from Nucleus 0.999999999979311 -2.06886402156925e-11 32 0 0 41 10285 R-HSA-211897 Cytochrome P450 - arranged by substrate type 0.999999999979323 -2.0677410886388e-11 68 0 0 41 10285 R-HSA-211000 Gene Silencing by RNA 0.999999999979457 -2.05432209475247e-11 137 0 0 41 10285 R-HSA-75955 RNA Polymerase II Transcription Elongation 0.999999999979682 -2.03175150060893e-11 65 0 0 41 10285 R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 0.999999999979682 -2.03175150060893e-11 65 0 0 41 10285 R-HSA-5334118 DNA methylation 0.999999999979682 -2.03175150060893e-11 65 0 0 41 10285 R-HSA-112382 Formation of RNA Pol II elongation complex 0.999999999979682 -2.03175150060893e-11 65 0 0 41 10285 R-HSA-913709 O-linked glycosylation of mucins 0.999999999979682 -2.03175150060893e-11 65 0 0 41 10285 R-HSA-983231 Factors involved in megakaryocyte development and platelet production 0.999999999980978 -1.90216245259953e-11 156 0 0 41 10285 R-HSA-111885 Opioid Signalling 0.999999999981063 -1.89371719304139e-11 85 0 0 41 10285 R-HSA-112315 Transmission across Chemical Synapses 0.999999999981105 -1.88948380927501e-11 217 0 0 41 10285 R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.999999999981194 -1.88061615803177e-11 75 0 0 41 10285 R-HSA-8854518 AURKA Activation by TPX2 0.999999999981194 -1.88061615803177e-11 75 0 0 41 10285 R-HSA-109606 Intrinsic Pathway for Apoptosis 0.999999999981253 -1.87468705437175e-11 44 0 0 41 10285 R-HSA-1296072 Voltage gated Potassium channels 0.999999999981253 -1.87468705437175e-11 44 0 0 41 10285 R-HSA-1660661 Sphingolipid de novo biosynthesis 0.999999999981253 -1.87468705437175e-11 44 0 0 41 10285 R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 0.999999999981253 -1.87468705437175e-11 44 0 0 41 10285 R-HSA-975634 Retinoid metabolism and transport 0.999999999981253 -1.87468705437175e-11 44 0 0 41 10285 R-HSA-6788656 Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism 0.999999999981253 -1.87468705437175e-11 44 0 0 41 10285 R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.999999999981405 -1.85945837227229e-11 70 0 0 41 10285 R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.999999999981405 -1.85945837227229e-11 70 0 0 41 10285 R-HSA-1474290 Collagen formation 0.999999999981999 -1.80006878071091e-11 93 0 0 41 10285 R-HSA-69273 Cyclin A/B1 associated events during G2/M transition 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-5620916 VxPx cargo-targeting to cilium 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-1250196 SHC1 events in ERBB2 signaling 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-5655332 Signaling by FGFR3 in disease 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-5621575 CD209 (DC-SIGN) signaling 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-373753 Nephrin interactions 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-140875 Common Pathway of Fibrin Clot Formation 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-77595 Processing of Intronless Pre-mRNAs 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-166663 Initial triggering of complement 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-5654712 FRS-mediated FGFR4 signaling 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-389513 CTLA4 inhibitory signaling 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-202131 Metabolism of nitric oxide 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-8853338 Signaling by FGFR3 point mutants in cancer 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-389357 CD28 dependent PI3K/Akt signaling 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-166208 mTORC1-mediated signalling 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-198753 ERK/MAPK targets 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-1482801 Acyl chain remodelling of PS 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-203765 eNOS activation and regulation 0.999999999982532 -1.746811244318e-11 22 0 0 41 10285 R-HSA-983189 Kinesins 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-168253 Host Interactions with Influenza Factors 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-1566948 Elastic fibre formation 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-6782315 tRNA modification in the nucleus and cytosol 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-1461957 Beta defensins 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-373752 Netrin-1 signaling 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 0.999999999982876 -1.71243098824116e-11 42 0 0 41 10285 R-HSA-1630316 Glycosaminoglycan metabolism 0.999999999983206 -1.6793538896892e-11 124 0 0 41 10285 R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.999999999983206 -1.6793538896892e-11 124 0 0 41 10285 R-HSA-1989781 PPARA activates gene expression 0.999999999983206 -1.6793538896892e-11 124 0 0 41 10285 R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 0.999999999983504 -1.64961419353521e-11 72 0 0 41 10285 R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome 0.999999999983504 -1.64961419353521e-11 72 0 0 41 10285 R-HSA-6794362 Protein-protein interactions at synapses 0.999999999983504 -1.64961419353521e-11 72 0 0 41 10285 R-HSA-774815 Nucleosome assembly 0.999999999983504 -1.64961419353521e-11 72 0 0 41 10285 R-HSA-380259 Loss of Nlp from mitotic centrosomes 0.999999999983504 -1.64961419353521e-11 72 0 0 41 10285 R-HSA-392451 G beta:gamma signalling through PI3Kgamma 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-418597 G alpha (z) signalling events 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-3928665 EPH-ephrin mediated repulsion of cells 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-112040 G-protein mediated events 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-380108 Chemokine receptors bind chemokines 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-4570464 SUMOylation of RNA binding proteins 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-73762 RNA Polymerase I Transcription Initiation 0.999999999983835 -1.61651779633743e-11 48 0 0 41 10285 R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 0.999999999984143 -1.58572640479699e-11 89 0 0 41 10285 R-HSA-3371556 Cellular response to heat stress 0.999999999984143 -1.58572640479699e-11 89 0 0 41 10285 R-HSA-1500620 Meiosis 0.999999999984719 -1.52807406465933e-11 121 0 0 41 10285 R-HSA-1221632 Meiotic synapsis 0.999999999985084 -1.49161633368173e-11 79 0 0 41 10285 R-HSA-109704 PI3K Cascade 0.999999999985084 -1.49161633368173e-11 79 0 0 41 10285 R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 0.999999999985084 -1.49161633368173e-11 79 0 0 41 10285 R-HSA-6807878 COPI-mediated anterograde transport 0.999999999985084 -1.49161633368173e-11 79 0 0 41 10285 R-HSA-3214858 RMTs methylate histone arginines 0.999999999985084 -1.49161633368173e-11 79 0 0 41 10285 R-HSA-1483255 PI Metabolism 0.999999999985084 -1.49161633368173e-11 79 0 0 41 10285 R-HSA-4615885 SUMOylation of DNA replication proteins 0.999999999985636 -1.43642674850173e-11 46 0 0 41 10285 R-HSA-70153 Glucose transport 0.999999999985636 -1.43642674850173e-11 46 0 0 41 10285 R-HSA-1660662 Glycosphingolipid metabolism 0.999999999985636 -1.43642674850173e-11 46 0 0 41 10285 R-HSA-3108214 SUMOylation of DNA damage response and repair proteins 0.999999999986544 -1.3455622628827e-11 78 0 0 41 10285 R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 0.999999999986544 -1.3455622628827e-11 78 0 0 41 10285 R-HSA-1632852 Macroautophagy 0.999999999986946 -1.30535809024487e-11 67 0 0 41 10285 R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 0.999999999986946 -1.30535809024487e-11 67 0 0 41 10285 R-HSA-73864 RNA Polymerase I Transcription 0.999999999987214 -1.27855833506052e-11 112 0 0 41 10285 R-HSA-727802 Transport of nucleotide sugars 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-167590 Nef Mediated CD4 Down-regulation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-399997 Acetylcholine regulates insulin secretion 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-74749 Signal attenuation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-193692 Regulated proteolysis of p75NTR 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-174437 Removal of the Flap Intermediate from the C-strand 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-418886 Netrin mediated repulsion signals 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-201688 WNT mediated activation of DVL 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-3215018 Processing and activation of SUMO 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-6811555 PI5P Regulates TP53 Acetylation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-419812 Calcitonin-like ligand receptors 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-168799 Neurotoxicity of clostridium toxins 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-418890 Role of second messengers in netrin-1 signaling 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-74259 Purine catabolism 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-427601 Multifunctional anion exchangers 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-209968 Thyroxine biosynthesis 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-8875656 MET receptor recycling 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-430116 GP1b-IX-V activation signalling 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-8868766 rRNA processing in the mitochondrion 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-2046105 Linoleic acid (LA) metabolism 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-70635 Urea cycle 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-428643 Organic anion transporters 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-425381 Bicarbonate transporters 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-190873 Gap junction degradation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-139915 Activation of PUMA and translocation to mitochondria 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-2465910 MASTL Facilitates Mitotic Progression 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-190377 FGFR2b ligand binding and activation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-112311 Neurotransmitter Clearance In The Synaptic Cleft 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-442380 Zinc influx into cells by the SLC39 gene family 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-2562578 TRIF-mediated programmed cell death 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-8853334 Signaling by FGFR3 fusions in cancer 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-110056 MAPK3 (ERK1) activation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-73929 Base-Excision Repair, AP Site Formation 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-5687613 Diseases associated with surfactant metabolism 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-1250342 PI3K events in ERBB4 signaling 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-170660 Adenylate cyclase activating pathway 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-196108 Pregnenolone biosynthesis 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-389887 Beta-oxidation of pristanoyl-CoA 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-159740 Gamma-carboxylation of protein precursors 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-1300644 Interaction With The Zona Pellucida 0.999999999987245 -1.27553442490999e-11 10 0 0 41 10285 R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 0.999999999987426 -1.25744270452905e-11 49 0 0 41 10285 R-HSA-6783783 Interleukin-10 signaling 0.999999999987426 -1.25744270452905e-11 49 0 0 41 10285 R-HSA-6791312 TP53 Regulates Transcription of Cell Cycle Genes 0.999999999987426 -1.25744270452905e-11 49 0 0 41 10285 R-HSA-212300 PRC2 methylates histones and DNA 0.999999999987928 -1.20716291603794e-11 74 0 0 41 10285 R-HSA-6802957 Oncogenic MAPK signaling 0.999999999987928 -1.20716291603794e-11 74 0 0 41 10285 R-HSA-2299718 Condensation of Prophase Chromosomes 0.999999999987928 -1.20716291603794e-11 74 0 0 41 10285 R-HSA-390918 Peroxisomal lipid metabolism 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-196807 Nicotinate metabolism 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-1482839 Acyl chain remodelling of PE 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-375170 CDO in myogenesis 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-202040 G-protein activation 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-5218920 VEGFR2 mediated vascular permeability 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-72086 mRNA Capping 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-525793 Myogenesis 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-442742 CREB phosphorylation through the activation of Ras 0.999999999988403 -1.15969256777474e-11 29 0 0 41 10285 R-HSA-5688890 Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-73928 Depyrimidination 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-1483115 Hydrolysis of LPC 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-3656534 Loss of Function of TGFBR1 in Cancer 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-174430 Telomere C-strand synthesis initiation 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-5688849 Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-196783 Coenzyme A biosynthesis 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-1483148 Synthesis of PG 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-444473 Formyl peptide receptors bind formyl peptides and many other ligands 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-177128 Conjugation of salicylate with glycine 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-3656532 TGFBR1 KD Mutants in Cancer 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-6787450 tRNA modification in the mitochondrion 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-5362798 Release of Hh-Np from the secreting cell 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-804914 Transport of fatty acids 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-193634 Axonal growth inhibition (RHOA activation) 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-210747 Regulation of gene expression in early pancreatic precursor cells 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-1482883 Acyl chain remodeling of DAG and TAG 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-68952 DNA replication initiation 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-977347 Serine biosynthesis 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-5576890 Phase 3 - rapid repolarisation 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-444821 Relaxin receptors 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-164944 Nef and signal transduction 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-2142789 Ubiquinol biosynthesis 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-8937144 Aryl hydrocarbon receptor signalling 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-110329 Cleavage of the damaged pyrimidine 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-5632681 Ligand-receptor interactions 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-72731 Recycling of eIF2:GDP 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-73942 DNA Damage Reversal 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-77111 Synthesis of Ketone Bodies 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-194313 VEGF ligand-receptor interactions 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-196836 Vitamin C (ascorbate) metabolism 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-448424 Interleukin-17 signaling 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-70921 Histidine catabolism 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-400451 Free fatty acids regulate insulin secretion 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-5358493 Synthesis of diphthamide-EEF2 0.999999999988642 -1.1358466027496e-11 8 0 0 41 10285 R-HSA-72172 mRNA Splicing 0.999999999988643 -1.13570363836259e-11 195 0 0 41 10285 R-HSA-418555 G alpha (s) signalling events 0.99999999998887 -1.1129942394544e-11 146 0 0 41 10285 R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell 0.99999999998887 -1.1129942394544e-11 146 0 0 41 10285 R-HSA-3214815 HDACs deacetylate histones 0.999999999988931 -1.1068637924634e-11 94 0 0 41 10285 R-HSA-199418 Negative regulation of the PI3K/AKT network 0.999999999988931 -1.1068637924634e-11 94 0 0 41 10285 R-HSA-5368287 Mitochondrial translation 0.999999999988931 -1.1068637924634e-11 94 0 0 41 10285 R-HSA-1445148 Translocation of GLUT4 to the plasma membrane 0.99999999998907 -1.09297026146873e-11 62 0 0 41 10285 R-HSA-6790901 rRNA modification in the nucleus and cytosol 0.99999999998907 -1.09297026146873e-11 62 0 0 41 10285 R-HSA-72187 mRNA 3'-end processing 0.99999999998907 -1.09297026146873e-11 62 0 0 41 10285 R-HSA-1268020 Mitochondrial protein import 0.99999999998907 -1.09297026146873e-11 62 0 0 41 10285 R-HSA-1638074 Keratan sulfate/keratin metabolism 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-180746 Nuclear import of Rev protein 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-389356 CD28 co-stimulation 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-4085001 Sialic acid metabolism 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-202433 Generation of second messenger molecules 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-1222556 ROS, RNS production in phagocytes 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-163359 Glucagon signaling in metabolic regulation 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-186712 Regulation of beta-cell development 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-1839126 FGFR2 mutant receptor activation 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-392518 Signal amplification 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-180910 Vpr-mediated nuclear import of PICs 0.999999999989263 -1.07367058627073e-11 33 0 0 41 10285 R-HSA-73856 RNA Polymerase II Transcription Termination 0.999999999989814 -1.01860247185889e-11 71 0 0 41 10285 R-HSA-109688 Cleavage of Growing Transcript in the Termination Region 0.999999999989814 -1.01860247185889e-11 71 0 0 41 10285 R-HSA-6809371 Formation of the cornified envelope 0.999999999989814 -1.01860247185889e-11 71 0 0 41 10285 R-HSA-5620924 Intraflagellar transport 0.999999999989832 -1.01681967288408e-11 41 0 0 41 10285 R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 0.999999999989832 -1.01681967288408e-11 41 0 0 41 10285 R-HSA-74158 RNA Polymerase III Transcription 0.999999999989832 -1.01681967288408e-11 41 0 0 41 10285 R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events 0.999999999989832 -1.01681967288408e-11 41 0 0 41 10285 R-HSA-68875 Mitotic Prophase 0.999999999990549 -9.45120879575975e-12 141 0 0 41 10285 R-HSA-211981 Xenobiotics 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-1538133 G0 and Early G1 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-425410 Metal ion SLC transporters 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-1614635 Sulfur amino acid metabolism 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-3000157 Laminin interactions 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-418592 ADP signalling through P2Y purinoceptor 1 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-3295583 TRP channels 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-982772 Growth hormone receptor signaling 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-5654708 Downstream signaling of activated FGFR3 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-429947 Deadenylation of mRNA 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-5654700 FRS-mediated FGFR2 signaling 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-997272 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-1296059 G protein gated Potassium channels 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-977068 Termination of O-glycan biosynthesis 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-933542 TRAF6 mediated NF-kB activation 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-203927 MicroRNA (miRNA) biogenesis 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-1296041 Activation of G protein gated Potassium channels 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-5673000 RAF activation 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-499943 Synthesis and interconversion of nucleotide di- and triphosphates 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-1251985 Nuclear signaling by ERBB4 0.99999999999084 -9.15975727524575e-12 25 0 0 41 10285 R-HSA-1483257 Phospholipid metabolism 0.999999999990856 -9.14354462058875e-12 207 0 0 41 10285 R-HSA-948021 Transport to the Golgi and subsequent modification 0.999999999990866 -9.13397837529033e-12 164 0 0 41 10285 R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-1502540 Signaling by Activin 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2995410 Nuclear Envelope Reassembly 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-3270619 IRF3-mediated induction of type I IFN 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-391160 Signal regulatory protein (SIRP) family interactions 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-74217 Purine salvage 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2029481 FCGR activation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-198323 AKT phosphorylates targets in the cytosol 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-432047 Passive transport by Aquaporins 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-112308 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-977441 GABA A receptor activation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-171007 p38MAPK events 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-71240 Tryptophan catabolism 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-202670 ERKs are inactivated 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-75205 Dissolution of Fibrin Clot 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-190375 FGFR2c ligand binding and activation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-425561 Sodium/Calcium exchangers 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5654227 Phospholipase C-mediated cascade; FGFR3 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5210891 Uptake and function of anthrax toxins 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5357786 TNFR1-induced proapoptotic signaling 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-190239 FGFR3 ligand binding and activation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-879415 Advanced glycosylation endproduct receptor signaling 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-75892 Platelet Adhesion to exposed collagen 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5626467 RHO GTPases activate IQGAPs 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2408517 SeMet incorporation into proteins 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2995383 Initiation of Nuclear Envelope Reformation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-140342 Apoptosis induced DNA fragmentation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-375281 Hormone ligand-binding receptors 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-190372 FGFR3c ligand binding and activation 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-1663150 The activation of arylsulfatases 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2168880 Scavenging of heme from plasma 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-8847993 ERBB2 Activates PTK6 Signaling 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-211227 Activation of DNA fragmentation factor 0.999999999990974 -9.02557897921038e-12 13 0 0 41 10285 R-HSA-210500 Glutamate Neurotransmitter Release Cycle 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-392154 Nitric oxide stimulates guanylate cyclase 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-171052 LDL-mediated lipid transport 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-70895 Branched-chain amino acid catabolism 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-5602358 Diseases associated with the TLR signaling cascade 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-201451 Signaling by BMP 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-191273 Cholesterol biosynthesis 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-5260271 Diseases of Immune System 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-156588 Glucuronidation 0.999999999991252 -8.74834822200168e-12 24 0 0 41 10285 R-HSA-71403 Citric acid cycle (TCA cycle) 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-176412 Phosphorylation of the APC/C 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-190861 Gap junction assembly 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-3928664 Ephrin signaling 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-888590 GABA synthesis, release, reuptake and degradation 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-442982 Ras activation uopn Ca2+ infux through NMDA receptor 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-5576886 Phase 4 - resting membrane potential 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-8851708 Signaling by FGFR2 IIIa TM 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-5223345 Miscellaneous transport and binding events 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-156584 Cytosolic sulfonation of small molecules 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-416700 Other semaphorin interactions 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-8876725 Protein methylation 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters 0.999999999991306 -8.69426076685467e-12 19 0 0 41 10285 R-HSA-429914 Deadenylation-dependent mRNA decay 0.999999999991378 -8.6224473110378e-12 57 0 0 41 10285 R-HSA-3000178 ECM proteoglycans 0.999999999991378 -8.6224473110378e-12 57 0 0 41 10285 R-HSA-418594 G alpha (i) signalling events 0.999999999991384 -8.61606584198703e-12 242 0 0 41 10285 R-HSA-3858516 Glycogen storage disease type 0 (liver GYS2) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-75102 C6 deamination of adenosine 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-68881 Mitotic Metaphase/Anaphase Transition 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-8942233 Intestinal infectious diseases 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-168316 Assembly of Viral Components at the Budding Site 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3359478 Defective MUT causes methylmalonic aciduria mut type 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-168277 Influenza Virus Induced Apoptosis 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3828062 Glycogen storage disease type 0 (muscle GYS1) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-844623 The IPAF inflammasome 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5602636 IKBKB deficiency causes SCID 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-75896 Plasmalogen biosynthesis 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-480985 Synthesis of dolichyl-phosphate-glucose 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-211728 Regulation of PAK-2p34 activity by PS-GAP/RHG10 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-166020 Transfer of LPS from LBP carrier to CD14 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3359475 Defective MMAA causes methylmalonic aciduria type cblA 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-192905 vRNP Assembly 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-203754 NOSIP mediated eNOS trafficking 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-211736 Stimulation of the cell death response by PAK-2p34 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-156582 Acetylation 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-177162 Conjugation of phenylacetate with glutamine 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5683177 Defective ABCC8 can cause hypoglycemias and hyperglycemias 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-1614603 Cysteine formation from homocysteine 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-8849175 Threonine catabolism 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5688354 Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-111995 phospho-PLA2 pathway 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-198765 Signalling to ERK5 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-168315 Inhibition of Host mRNA Processing and RNA Silencing 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5652227 Fructose biosynthesis 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5619107 Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-8854521 Interaction between PHLDA1 and AURKA 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-1483152 Hydrolysis of LPE 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-380612 Metabolism of serotonin 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-70688 Proline catabolism 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-77042 Formation of editosomes by ADAR proteins 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-451307 Activation of Na-permeable Kainate Receptors 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-168268 Virus Assembly and Release 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-114294 Activation, translocation and oligomerization of BAX 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-71737 Pyrophosphate hydrolysis 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3359467 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-111452 Activation and oligomerization of BAK protein 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-190872 Transport of connexons to the plasma membrane 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-351143 Agmatine biosynthesis 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-75064 mRNA Editing: A to I Conversion 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5687868 Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-1483101 Synthesis of PS 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3642279 TGFBR2 MSI Frameshift Mutants in Cancer 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-205017 NFG and proNGF binds to p75NTR 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-916853 Degradation of GABA 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5579031 Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-211994 Sterols are 12-hydroxylated by CYP8B1 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-165160 PDE3B signalling 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-888568 GABA synthesis 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-164939 Nef mediated downregulation of CD28 cell surface expression 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3359469 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-141334 PAOs oxidise polyamines to amines 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5357609 Glycogen storage disease type II (GAA) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-1299361 TWIK-related alkaline pH activated K+ channel (TALK) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3359485 Defective CD320 causes methylmalonic aciduria 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-141424 Amplification of signal from the kinetochores 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-432030 Transport of glycerol from adipocytes to the liver by Aquaporins 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-187042 TRKA activation by NGF 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-111457 Release of apoptotic factors from the mitochondria 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-5602566 TICAM1 deficiency - HSE 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-428559 Proton-coupled neutral amino acid transporters 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-168275 Entry of Influenza Virion into Host Cell via Endocytosis 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3814836 Glycogen storage disease type XV (GYG1) 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-6804754 Regulation of TP53 Expression 0.99999999999145 -8.5495960456389e-12 2 0 0 41 10285 R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins 0.999999999991708 -8.29187098174998e-12 104 0 0 41 10285 R-HSA-3000170 Syndecan interactions 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-69186 Lagging Strand Synthesis 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-6788467 IL-6-type cytokine receptor ligand interactions 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-8874081 MET activates PTK2 signaling 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-5654720 PI-3K cascade:FGFR4 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-418217 G beta:gamma signalling through PLC beta 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-5654706 FRS-mediated FGFR3 signaling 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-450302 activated TAK1 mediates p38 MAPK activation 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-190241 FGFR2 ligand binding and activation 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-141405 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-5654719 SHC-mediated cascade:FGFR4 0.999999999991912 -8.08770534356295e-12 20 0 0 41 10285 R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-379724 tRNA Aminoacylation 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-3000171 Non-integrin membrane-ECM interactions 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-8854214 TBC/RABGAPs 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-6811438 Intra-Golgi traffic 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-166658 Complement cascade 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts 0.999999999992077 -7.92287669522338e-12 45 0 0 41 10285 R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 0.999999999992234 -7.76572550018162e-12 87 0 0 41 10285 R-HSA-5368286 Mitochondrial translation initiation 0.999999999992234 -7.76572550018162e-12 87 0 0 41 10285 R-HSA-351202 Metabolism of polyamines 0.999999999992234 -7.76572550018162e-12 87 0 0 41 10285 R-HSA-5419276 Mitochondrial translation termination 0.999999999992234 -7.76572550018162e-12 87 0 0 41 10285 R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.999999999992234 -7.76572550018162e-12 87 0 0 41 10285 R-HSA-2187338 Visual phototransduction 0.999999999992406 -7.59390926344302e-12 101 0 0 41 10285 R-HSA-373760 L1CAM interactions 0.999999999992406 -7.59390926344302e-12 101 0 0 41 10285 R-HSA-419037 NCAM1 interactions 0.999999999993016 -6.98366776874292e-12 37 0 0 41 10285 R-HSA-438064 Post NMDA receptor activation events 0.999999999993016 -6.98366776874292e-12 37 0 0 41 10285 R-HSA-73884 Base Excision Repair 0.999999999993016 -6.98366776874292e-12 37 0 0 41 10285 R-HSA-176187 Activation of ATR in response to replication stress 0.999999999993016 -6.98366776874292e-12 37 0 0 41 10285 R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) 0.999999999993016 -6.98366776874292e-12 37 0 0 41 10285 R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.999999999993016 -6.98366776874292e-12 37 0 0 41 10285 R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1839128 FGFR4 mutant receptor activation 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5250982 Toxicity of tetanus toxin (TeNT) 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-2023837 Signaling by FGFR2 amplification mutants 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-3359474 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-8853333 Signaling by FGFR2 fusions 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-140180 COX reactions 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-164516 Minus-strand DNA synthesis 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-2033515 t(4;14) translocations of FGFR3 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5263617 Metabolism of ingested MeSeO2H into MeSeH 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1222352 Latent infection of Homo sapiens with Mycobacterium tuberculosis 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-2534343 Interaction With Cumulus Cells 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-6809583 Retinoid metabolism disease events 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1222499 Response of Mtb to phagocytosis 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5602410 TLR3 deficiency - HSE 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-168330 Viral RNP Complexes in the Host Cell Nucleus 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1855231 Synthesis of IPs in the ER lumen 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1483196 PI and PC transport between ER and Golgi membranes 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5619110 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5657655 MGMT-mediated DNA damage reversal 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-162585 Uncoating of the HIV Virion 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-389542 NADPH regeneration 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1222449 Mtb iron assimilation by chelation 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-163316 Mitochondrial transcription termination 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-169131 Inhibition of PKR 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-162589 Reverse Transcription of HIV RNA 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-171286 Synthesis and processing of ENV and VPU 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1483076 Synthesis of CL 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-2466712 Biosynthesis of A2E, implicated in retinal degradation 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5602415 UNC93B1 deficiency - HSE 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-3359454 Defective TCN2 causes hereditary megaloblastic anemia 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-112122 ALKBH2 mediated reversal of alkylation damage 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-2408552 Methylation of MeSeH for excretion 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-3248023 Regulation by TREX1 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5340573 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-975574 Reactions specific to the hybrid N-glycan synthesis pathway 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1300645 Acrosome Reaction 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1299344 TWIK-related spinal cord K+ channel (TRESK) 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-164525 Plus-strand DNA synthesis 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-1839120 Signaling by FGFR1 amplification mutants 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-3359457 Defective GIF causes intrinsic factor deficiency 0.999999999993165 -6.8350611628909e-12 1 0 0 41 10285 R-HSA-5173105 O-linked glycosylation 0.999999999993257 -6.74274756239806e-12 114 0 0 41 10285 R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 0.999999999993714 -6.28610031124414e-12 179 0 0 41 10285 R-HSA-6807505 RNA polymerase II transcribes snRNA genes 0.999999999993873 -6.1270063114828e-12 73 0 0 41 10285 R-HSA-3214841 PKMTs methylate histone lysines 0.999999999993873 -6.1270063114828e-12 73 0 0 41 10285 R-HSA-4086398 Ca2+ pathway 0.999999999994065 -5.93457953812789e-12 61 0 0 41 10285 R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-194002 Glucocorticoid biosynthesis 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-390696 Adrenoceptors 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-166665 Terminal pathway of complement 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-189085 Digestion of dietary carbohydrate 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-156587 Amino Acid conjugation 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2179392 EGFR Transactivation by Gastrin 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2243919 Crosslinking of collagen fibrils 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-163765 ChREBP activates metabolic gene expression 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-447041 CHL1 interactions 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-196025 Formation of annular gap junctions 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-162592 Integration of provirus 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-159424 Conjugation of carboxylic acids 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-419771 Opsins 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-193697 p75NTR regulates axonogenesis 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2453864 Retinoid cycle disease events 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2214320 Anchoring fibril formation 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-629597 Highly calcium permeable nicotinic acetylcholine receptors 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-428890 Role of Abl in Robo-Slit signaling 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-425986 Sodium/Proton exchangers 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2428933 SHC-related events triggered by IGF1R 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-71336 Pentose phosphate pathway (hexose monophosphate shunt) 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-1614558 Degradation of cysteine and homocysteine 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-5340588 RNF mutants show enhanced WNT signaling and proliferation 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-1296052 Ca2+ activated K+ channels 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-2474795 Diseases associated with visual transduction 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-391908 Prostanoid ligand receptors 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-75094 Formation of the Editosome 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-8854691 Interleukin-19, 20, 22, 24 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-426486 Small interfering RNA (siRNA) biogenesis 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-1462054 Alpha-defensins 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-428543 Inactivation of Cdc42 and Rac 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-74182 Ketone body metabolism 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-112411 MAPK1 (ERK2) activation 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-110357 Displacement of DNA glycosylase by APEX1 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-72200 mRNA Editing: C to U Conversion 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-1300642 Sperm Motility And Taxes 0.999999999994235 -5.76481420331478e-12 9 0 0 41 10285 R-HSA-3238698 WNT ligand biogenesis and trafficking 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-379716 Cytosolic tRNA aminoacylation 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-2029485 Role of phospholipids in phagocytosis 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-975298 Ligand-gated ion channel transport 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-1474165 Reproduction 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-73848 Pyrimidine metabolism 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-912694 Regulation of IFNA signaling 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-1187000 Fertilization 0.999999999994625 -5.37522062658703e-12 26 0 0 41 10285 R-HSA-73777 RNA Polymerase I Chain Elongation 0.999999999994828 -5.17173727764596e-12 91 0 0 41 10285 R-HSA-418346 Platelet homeostasis 0.999999999994828 -5.17173727764596e-12 91 0 0 41 10285 R-HSA-2980736 Peptide hormone metabolism 0.999999999994828 -5.17173727764596e-12 91 0 0 41 10285 R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 0.999999999994828 -5.17173727764596e-12 91 0 0 41 10285 R-HSA-15869 Metabolism of nucleotides 0.999999999994855 -5.14506058620474e-12 97 0 0 41 10285 R-HSA-6803157 Antimicrobial peptides 0.999999999994855 -5.14506058620474e-12 97 0 0 41 10285 R-HSA-6802952 Signaling by BRAF and RAF fusions 0.999999999995134 -4.86566156599927e-12 60 0 0 41 10285 R-HSA-193648 NRAGE signals death through JNK 0.999999999995134 -4.86566156599927e-12 60 0 0 41 10285 R-HSA-6784531 tRNA processing in the nucleus 0.999999999995134 -4.86566156599927e-12 60 0 0 41 10285 R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.999999999995134 -4.86566156599927e-12 60 0 0 41 10285 R-HSA-211859 Biological oxidations 0.999999999995483 -4.51752100551476e-12 222 0 0 41 10285 R-HSA-163685 Integration of energy metabolism 0.999999999995532 -4.46842482858027e-12 111 0 0 41 10285 R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) 0.99999999999576 -4.23979289939359e-12 127 0 0 41 10285 R-HSA-1834941 STING mediated induction of host immune responses 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-399954 Sema3A PAK dependent Axon repulsion 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-5637812 Signaling by EGFRvIII in Cancer 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-392517 Rap1 signalling 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-1433559 Regulation of KIT signaling 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-163615 PKA activation 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-446353 Cell-extracellular matrix interactions 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-1963640 GRB2 events in ERBB2 signaling 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-5686938 Regulation of TLR by endogenous ligand 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-190242 FGFR1 ligand binding and activation 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-372708 p130Cas linkage to MAPK signaling for integrins 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-399956 CRMPs in Sema3A signaling 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-5213460 RIPK1-mediated regulated necrosis 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-1170546 Prolactin receptor signaling 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-418038 Nucleotide-like (purinergic) receptors 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-918233 TRAF3-dependent IRF activation pathway 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-549132 Organic cation/anion/zwitterion transport 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-1963642 PI3K events in ERBB2 signaling 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-159418 Recycling of bile acids and salts 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-5218859 Regulated Necrosis 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-5637810 Constitutive Signaling by EGFRvIII 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-163210 Formation of ATP by chemiosmotic coupling 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 0.999999999996014 -3.98575371604532e-12 16 0 0 41 10285 R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 0.999999999996125 -3.87463332978676e-12 113 0 0 41 10285 R-HSA-427413 NoRC negatively regulates rRNA expression 0.999999999996386 -3.61361230447722e-12 107 0 0 41 10285 R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 0.999999999996386 -3.61361230447722e-12 107 0 0 41 10285 R-HSA-5669034 TNFs bind their physiological receptors 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-917977 Transferrin endocytosis and recycling 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-381042 PERK regulates gene expression 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-420092 Glucagon-type ligand receptors 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-5683826 Surfactant metabolism 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-111996 Ca-dependent events 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-157858 Gap junction trafficking and regulation 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-5654696 Downstream signaling of activated FGFR2 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-2871809 FCERI mediated Ca+2 mobilization 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-445095 Interaction between L1 and Ankyrins 0.999999999996446 -3.55410217561177e-12 30 0 0 41 10285 R-HSA-6802949 Signaling by RAS mutants 0.999999999996563 -3.43693834537738e-12 50 0 0 41 10285 R-HSA-1660499 Synthesis of PIPs at the plasma membrane 0.999999999996563 -3.43693834537738e-12 50 0 0 41 10285 R-HSA-167169 HIV Transcription Elongation 0.999999999996563 -3.43693834537738e-12 50 0 0 41 10285 R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 0.999999999996563 -3.43693834537738e-12 50 0 0 41 10285 R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 0.999999999996563 -3.43693834537738e-12 50 0 0 41 10285 R-HSA-445717 Aquaporin-mediated transport 0.999999999997831 -2.16909067324813e-12 52 0 0 41 10285 R-HSA-3214842 HDMs demethylate histones 0.999999999997831 -2.16909067324813e-12 52 0 0 41 10285 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.999999999997831 -2.16909067324813e-12 52 0 0 41 10285 R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 0.999999999997831 -2.16909067324813e-12 52 0 0 41 10285 R-HSA-2980766 Nuclear Envelope Breakdown 0.999999999997831 -2.16909067324813e-12 52 0 0 41 10285 R-HSA-381038 XBP1(S) activates chaperone genes 0.999999999998033 -1.96723809345357e-12 56 0 0 41 10285 R-HSA-977443 GABA receptor activation 0.999999999998033 -1.96723809345357e-12 56 0 0 41 10285 R-HSA-416476 G alpha (q) signalling events 0.999999999998055 -1.94471163796413e-12 192 0 0 41 10285 R-HSA-5617833 Cilium Assembly 0.999999999998055 -1.94471163796413e-12 192 0 0 41 10285 R-HSA-397795 G-protein beta:gamma signalling 0.999999999998173 -1.82720705052731e-12 51 0 0 41 10285 R-HSA-171306 Packaging Of Telomere Ends 0.999999999998173 -1.82720705052731e-12 51 0 0 41 10285 R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.999999999998173 -1.82720705052731e-12 51 0 0 41 10285 R-HSA-112310 Neurotransmitter Release Cycle 0.999999999998173 -1.82720705052731e-12 51 0 0 41 10285 R-HSA-6799198 Complex I biogenesis 0.999999999998173 -1.82720705052731e-12 51 0 0 41 10285 R-HSA-1461973 Defensins 0.999999999998173 -1.82720705052731e-12 51 0 0 41 10285 R-HSA-1793185 Chondroitin sulfate/dermatan sulfate metabolism 0.999999999998173 -1.82720705052731e-12 51 0 0 41 10285 R-HSA-1296071 Potassium Channels 0.99999999999873 -1.27032135970179e-12 100 0 0 41 10285 R-HSA-5620912 Anchoring of the basal body to the plasma membrane 0.99999999999873 -1.27032135970179e-12 100 0 0 41 10285 R-HSA-177243 Interactions of Rev with host cellular proteins 0.999999999998969 -1.03100143029889e-12 36 0 0 41 10285 R-HSA-2514856 The phototransduction cascade 0.999999999998969 -1.03100143029889e-12 36 0 0 41 10285 R-HSA-76046 RNA Polymerase III Transcription Initiation 0.999999999998969 -1.03100143029889e-12 36 0 0 41 10285 R-HSA-167021 PLC-gamma1 signalling 0.999999999998969 -1.03100143029889e-12 36 0 0 41 10285 R-HSA-176033 Interactions of Vpr with host cellular proteins 0.999999999998969 -1.03100143029889e-12 36 0 0 41 10285 R-HSA-212718 EGFR interacts with phospholipase C-gamma 0.999999999998969 -1.03100143029889e-12 36 0 0 41 10285 R-HSA-432720 Lysosome Vesicle Biogenesis 0.999999999998969 -1.03100143029889e-12 36 0 0 41 10285 R-HSA-975577 N-Glycan antennae elongation 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-68884 Mitotic Telophase/Cytokinesis 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-6785631 ERBB2 Regulates Cell Motility 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-211935 Fatty acids 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-3371568 Attenuation phase 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5099900 WNT5A-dependent internalization of FZD4 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-111447 Activation of BAD and translocation to mitochondria 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5358508 Mismatch Repair 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-156581 Methylation 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-2046106 alpha-linolenic acid (ALA) metabolism 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-170670 Adenylate cyclase inhibitory pathway 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-391903 Eicosanoid ligand-binding receptors 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-997269 Inhibition of adenylate cyclase pathway 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-4419969 Depolymerisation of the Nuclear Lamina 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-69183 Processive synthesis on the lagging strand 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5682910 LGI-ADAM interactions 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated 0.999999999998992 -1.00823314655433e-12 15 0 0 41 10285 R-HSA-75105 Fatty Acyl-CoA Biosynthesis 0.999999999999341 -6.58646930536237e-13 55 0 0 41 10285 R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 0.999999999999341 -6.58646930536237e-13 55 0 0 41 10285 R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 1.0000000000002 2.02186947968543e-13 122 0 0 41 10285 R-HSA-2990846 SUMOylation 1.00000000000059 5.93694155897206e-13 110 0 0 41 10285 R-HSA-73854 RNA Polymerase I Promoter Clearance 1.00000000000059 5.93694155897206e-13 110 0 0 41 10285 R-HSA-5250941 Negative epigenetic regulation of rRNA expression 1.00000000000059 5.93694155897206e-13 110 0 0 41 10285 R-HSA-8856688 Golgi-to-ER retrograde transport 1.00000000000059 5.93694155897206e-13 110 0 0 41 10285 R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription 1.00000000000064 6.43406995213166e-13 149 0 0 41 10285 R-HSA-674695 RNA Polymerase II Pre-transcription Events 1.00000000000142 1.42029697460258e-12 88 0 0 41 10285 R-HSA-5389840 Mitochondrial translation elongation 1.00000000000142 1.42029697460258e-12 88 0 0 41 10285 R-HSA-912446 Meiotic recombination 1.00000000000142 1.42029697460258e-12 88 0 0 41 10285 R-HSA-390650 Histamine receptors 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-1855191 Synthesis of IPs in the nucleus 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-428776 Class II GLUTs 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-194306 Neurophilin interactions with VEGF and VEGFR 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-112126 ALKBH3 mediated reversal of alkylation damage 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-8935690 Miscellaneous digestion events 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-1296025 ATP sensitive Potassium channels 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-1296053 Classical Kir channels 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-75108 Activation, myristolyation of BID and translocation to mitochondria 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-6803544 Ion influx/efflux at host-pathogen interface 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-211163 AKT-mediated inactivation of FOXO1A 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-379401 Dopamine clearance from the synaptic cleft 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-428542 Regulation of Commissural axon pathfinding by Slit and Robo 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-399710 Activation of AMPA receptors 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-6783984 Glycine degradation 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-8849474 PTK6 Activates STAT3 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-442745 Activation of CaMK IV 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A) 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-8847453 Synthesis of PIPs in the nucleus 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-2473224 Antagonism of Activin by Follistatin 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-165158 Activation of AKT2 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-1296061 HCN channels 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-5619099 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-1251932 PLCG1 events in ERBB2 signaling 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-69560 Transcriptional activation of p53 responsive genes 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-888593 Reuptake of GABA 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-209563 Axonal growth stimulation 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-75944 Transcription from mitochondrial promoters 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-176034 Interactions of Tat with host cellular proteins 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-8848584 Wax biosynthesis 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-6807062 Cholesterol biosynthesis via lathosterol 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-112313 Neurotransmitter uptake and Metabolism In Glial Cells 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-140179 Amine Oxidase reactions 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-167060 NGF processing 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-417973 Adenosine P1 receptors 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-3878781 Glycogen storage disease type IV (GBE1) 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-447115 Interleukin-12 signaling 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-204626 Hypusine synthesis from eIF5A-lysine 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-5603037 IRAK4 deficiency (TLR5) 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-69895 Transcriptional activation of cell cycle inhibitor p21 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-1369007 Mitochondrial ABC transporters 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-209905 Catecholamine biosynthesis 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-6807047 Cholesterol biosynthesis via desmosterol 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-173736 Alternative complement activation 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-4551638 SUMOylation of chromatin organization proteins 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-427975 Proton/oligopeptide cotransporters 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-173107 Binding and entry of HIV virion 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-3000497 Scavenging by Class H Receptors 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 1.00000000000167 1.67179267817517e-12 4 0 0 41 10285 R-HSA-196854 Metabolism of vitamins and cofactors 1.00000000000185 1.85504844785433e-12 174 0 0 41 10285 R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-977444 GABA B receptor activation 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-167287 HIV elongation arrest and recovery 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-109703 PKB-mediated events 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-168276 NS1 Mediated Effects on Host Pathways 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-167290 Pausing and recovery of HIV elongation 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-1442490 Collagen degradation 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-991365 Activation of GABAB receptors 1.00000000000201 2.01488031263745e-12 40 0 0 41 10285 R-HSA-194068 Bile acid and bile salt metabolism 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-5362517 Signaling by Retinoic Acid 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-375280 Amine ligand-binding receptors 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-5655253 Signaling by FGFR2 in disease 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-168325 Viral Messenger RNA Synthesis 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 1.00000000000228 2.28272918702508e-12 43 0 0 41 10285 R-HSA-2132295 MHC class II antigen presentation 1.00000000000236 2.36404033579481e-12 103 0 0 41 10285 R-HSA-445144 Signal transduction by L1 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-2028269 Signaling by Hippo 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-2024096 HS-GAG degradation 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-500657 Presynaptic function of Kainate receptors 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-5423646 Aflatoxin activation and detoxification 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-1181150 Signaling by NODAL 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-5654688 SHC-mediated cascade:FGFR1 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-8849932 SALM protein interactions at the synapses 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-210745 Regulation of gene expression in beta cells 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-5654689 PI-3K cascade:FGFR1 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-2022870 Chondroitin sulfate biosynthesis 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-69618 Mitotic Spindle Checkpoint 1.00000000000255 2.55217485441157e-12 21 0 0 41 10285 R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.00000000000363 3.62541554722549e-12 247 0 0 41 10285 R-HSA-199977 ER to Golgi Anterograde Transport 1.00000000000363 3.63466935364505e-12 133 0 0 41 10285 R-HSA-500792 GPCR ligand binding 1.00000000000399 3.98636443948168e-12 453 0 0 41 10285 R-HSA-2142845 Hyaluronan metabolism 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-1482922 Acyl chain remodelling of PI 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-70221 Glycogen breakdown (glycogenolysis) 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-3232118 SUMOylation of transcription factors 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-435354 Zinc transporters 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-199220 Vitamin B5 (pantothenate) metabolism 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-2033519 Activated point mutants of FGFR2 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-196299 Beta-catenin phosphorylation cascade 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-442729 CREB phosphorylation through the activation of CaMKII 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-189445 Metabolism of porphyrins 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-164378 PKA activation in glucagon signalling 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-156711 Polo-like kinase mediated events 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-192456 Digestion of dietary lipid 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-432142 Platelet sensitization by LDL 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-3296482 Defects in vitamin and cofactor metabolism 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-622312 Inflammasomes 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-111931 PKA-mediated phosphorylation of CREB 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-139853 Elevation of cytosolic Ca2+ levels 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-140534 Ligand-dependent caspase activation 1.00000000000461 4.60988565902756e-12 17 0 0 41 10285 R-HSA-8865999 MET activates PTPN11 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-2161541 Abacavir metabolism 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-111469 SMAC-mediated apoptotic response 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-5683678 Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3) 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-70350 Fructose catabolism 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D) 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-390648 Muscarinic acetylcholine receptors 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-77352 Beta oxidation of butanoyl-CoA to acetyl-CoA 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-1606341 IRF3 mediated activation of type 1 IFN 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-6785470 tRNA processing in the mitochondrion 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-180689 APOBEC3G mediated resistance to HIV-1 infection 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-3656535 TGFBR1 LBD Mutants in Cancer 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-167826 The fatty acid cycling model 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8852405 Signaling by MST1 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-112303 Electric Transmission Across Gap Junctions 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-71032 Propionyl-CoA catabolism 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8853383 Lysosomal oligosaccharide catabolism 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-5662702 Melanin biosynthesis 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-561048 Organic anion transport 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-75157 FasL/ CD95L signaling 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-389599 Alpha-oxidation of phytanate 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F) 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-68911 G2 Phase 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8866423 VLDL biosynthesis 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-114516 Disinhibition of SNARE formation 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-380095 Tachykinin receptors bind tachykinins 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-111461 Cytochrome c-mediated apoptotic response 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-187024 NGF-independant TRKA activation 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8875513 MET interacts with TNS proteins 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-203641 NOSTRIN mediated eNOS trafficking 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-157881 Cyclin B2 mediated events 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-3000471 Scavenging by Class B Receptors 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-111463 SMAC binds to IAPs 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-111448 Activation of NOXA and translocation to mitochondria 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-111464 SMAC-mediated dissociation of IAP:caspase complexes 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-1306955 GRB7 events in ERBB2 signaling 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-167827 The proton buffering model 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-390651 Dopamine receptors 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-1614517 Sulfide oxidation to sulfate 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-140834 Extrinsic Pathway of Fibrin Clot Formation 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-70370 Galactose catabolism 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-1483226 Synthesis of PI 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-426048 Arachidonate production from DAG 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-112307 Transmission across Electrical Synapses 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-391906 Leukotriene receptors 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-196819 Vitamin B1 (thiamin) metabolism 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-2142850 Hyaluronan biosynthesis and export 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-74713 IRS activation 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8866376 Reelin signalling pathway 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-5661270 Catabolism of glucuronate to xylulose-5-phosphate 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-69478 G2/M DNA replication checkpoint 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-8849468 PTK6 Regulates Proteins Involved in RNA Processing 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-209931 Serotonin and melatonin biosynthesis 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-2644605 FBXW7 Mutants and NOTCH1 in Cancer 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-446205 Synthesis of GDP-mannose 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-166187 Mitochondrial Uncoupling Proteins 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-71262 Carnitine synthesis 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-427652 Sodium-coupled phosphate cotransporters 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-3642278 Loss of Function of TGFBR2 in Cancer 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-1300652 Sperm:Oocyte Membrane Binding 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-1169092 Activation of RAS in B cells 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-444209 Free fatty acid receptors 1.00000000000479 4.79104133433696e-12 5 0 0 41 10285 R-HSA-1638091 Heparan sulfate/heparin (HS-GAG) metabolism 1.00000000000531 5.31390644803244e-12 54 0 0 41 10285 R-HSA-1592230 Mitochondrial biogenesis 1.00000000000531 5.31390644803244e-12 54 0 0 41 10285 R-HSA-189200 Hexose transport 1.00000000000531 5.31390644803244e-12 54 0 0 41 10285 R-HSA-418360 Platelet calcium homeostasis 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-1839124 FGFR1 mutant receptor activation 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-352230 Amino acid transport across the plasma membrane 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-114452 Activation of BH3-only proteins 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-2129379 Molecules associated with elastic fibres 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-5339562 Uptake and actions of bacterial toxins 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-5654687 Downstream signaling of activated FGFR1 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-73772 RNA Polymerase I Promoter Escape 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-180786 Extension of Telomeres 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-75067 Processing of Capped Intronless Pre-mRNA 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-70614 Amino acid synthesis and interconversion (transamination) 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-6804758 Regulation of TP53 Activity through Acetylation 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-8875878 MET promotes cell motility 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-1296065 Inwardly rectifying K+ channels 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-2022928 HS-GAG biosynthesis 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-418990 Adherens junctions interactions 1.00000000000545 5.44938830088409e-12 31 0 0 41 10285 R-HSA-167172 Transcription of the HIV genome 1.00000000000552 5.51842931034881e-12 77 0 0 41 10285 R-HSA-112316 Neuronal System 1.00000000000557 5.56953389505259e-12 349 0 0 41 10285 R-HSA-165159 mTOR signalling 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-5674135 MAP2K and MAPK activation 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-111465 Apoptotic cleavage of cellular proteins 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 1.00000000000562 5.62213923564158e-12 39 0 0 41 10285 R-HSA-381753 Olfactory Signaling Pathway 1.00000000000574 5.73929080264796e-12 391 0 0 41 10285 R-HSA-76009 Platelet Aggregation (Plug Formation) 1.00000000000607 6.06719128270992e-12 38 0 0 41 10285 R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 1.00000000000607 6.06719128270992e-12 38 0 0 41 10285 R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 1.00000000000607 6.06719128270992e-12 38 0 0 41 10285 R-HSA-3299685 Detoxification of Reactive Oxygen Species 1.00000000000607 6.06719128270992e-12 38 0 0 41 10285 R-HSA-5685938 HDR through Single Strand Annealing (SSA) 1.00000000000607 6.06719128270992e-12 38 0 0 41 10285 R-HSA-5655302 Signaling by FGFR1 in disease 1.00000000000607 6.06719128270992e-12 38 0 0 41 10285 R-HSA-156590 Glutathione conjugation 1.00000000000607 6.06719128270992e-12 38 0 0 41 10285 R-HSA-428157 Sphingolipid metabolism 1.00000000000629 6.28912891520558e-12 90 0 0 41 10285 R-HSA-1852241 Organelle biogenesis and maintenance 1.00000000000642 6.42472693949533e-12 340 0 0 41 10285 R-HSA-5693537 Resolution of D-Loop Structures 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-4791275 Signaling by WNT in cancer 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-933541 TRAF6 mediated IRF7 activation 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-113418 Formation of the Early Elongation Complex 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 1.00000000000672 6.72427232189783e-12 35 0 0 41 10285 R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-75953 RNA Polymerase II Transcription Initiation 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-73776 RNA Polymerase II Promoter Escape 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-167162 RNA Polymerase II HIV Promoter Escape 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-5576892 Phase 0 - rapid depolarisation 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-112043 PLC beta mediated events 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-8948216 Collagen chain trimerization 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-167161 HIV Transcription Initiation 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-1483249 Inositol phosphate metabolism 1.00000000000782 7.82233766911004e-12 47 0 0 41 10285 R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism 1.00000000000831 8.30581237500897e-12 253 0 0 41 10285 R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 1.00000000000847 8.46875538484733e-12 322 0 0 41 10285 R-HSA-73728 RNA Polymerase I Promoter Opening 1.00000000000851 8.50566896890286e-12 63 0 0 41 10285 R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 1.00000000000851 8.50566896890286e-12 63 0 0 41 10285 R-HSA-1226099 Signaling by FGFR in disease 1.00000000000851 8.50566896890286e-12 63 0 0 41 10285 R-HSA-156580 Phase II conjugation 1.00000000000884 8.83971396905226e-12 106 0 0 41 10285 R-HSA-5578749 Transcriptional regulation by small RNAs 1.00000000000884 8.83971396905226e-12 106 0 0 41 10285 R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-113510 E2F mediated regulation of DNA replication 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-165054 Rev-mediated nuclear export of HIV RNA 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-159227 Transport of the SLBP independent Mature mRNA 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-73847 Purine metabolism 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-192105 Synthesis of bile acids and bile salts 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-5694530 Cargo concentration in the ER 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-390522 Striated Muscle Contraction 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-1483166 Synthesis of PA 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-1489509 DAG and IP3 signaling 1.00000000000893 8.93020501123942e-12 34 0 0 41 10285 R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-447043 Neurofascin interactions 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-190371 FGFR3b ligand binding and activation 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-162791 Attachment of GPI anchor to uPAR 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-5619102 SLC transporter disorders 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-5603029 IkBA variant leads to EDA-ID 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-196843 Vitamin B2 (riboflavin) metabolism 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-426496 Post-transcriptional silencing by small RNAs 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3595177 Defective CHSY1 causes TPBS 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-171319 Telomere Extension By Telomerase 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3595172 Defective CHST3 causes SEDCJD 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-448706 Interleukin-1 processing 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-182218 Nef Mediated CD8 Down-regulation 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-199920 CREB phosphorylation 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-164843 2-LTR circle formation 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-6814848 Glycerophospholipid catabolism 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-75158 TRAIL signaling 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-426117 Cation-coupled Chloride cotransporters 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-174577 Activation of C3 and C5 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-73943 Reversal of alkylation damage by DNA dioxygenases 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-429593 Inositol transporters 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-420597 Nectin/Necl trans heterodimerization 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-5652084 Fructose metabolism 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-174362 Transport and synthesis of PAPS 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-447038 NrCAM interactions 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-3656225 Defective CHST6 causes MCDC1 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-196791 Vitamin D (calciferol) metabolism 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-111471 Apoptotic factor-mediated response 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-629587 Highly sodium permeable acetylcholine nicotinic receptors 1.00000000000928 9.2758716075382e-12 7 0 0 41 10285 R-HSA-73886 Chromosome Maintenance 1.00000000000949 9.49266676874745e-12 109 0 0 41 10285 R-HSA-72306 tRNA processing 1.00000000000949 9.49266676874745e-12 109 0 0 41 10285 R-HSA-211945 Phase 1 - Functionalization of compounds 1.00000000000949 9.49266676874745e-12 109 0 0 41 10285 R-HSA-8873719 RAB geranylgeranylation 1.00000000000978 9.78259756359885e-12 64 0 0 41 10285 R-HSA-73857 RNA Polymerase II Transcription 1.00000000001002 1.00175275016078e-11 159 0 0 41 10285 R-HSA-375276 Peptide ligand-binding receptors 1.00000000001031 1.0307534444765e-11 188 0 0 41 10285 R-HSA-209776 Amine-derived hormones 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-1482925 Acyl chain remodelling of PG 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-1369062 ABC transporters in lipid homeostasis 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-5654704 SHC-mediated cascade:FGFR3 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-912631 Regulation of signaling by CBL 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-5654710 PI-3K cascade:FGFR3 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-69205 G1/S-Specific Transcription 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-73780 RNA Polymerase III Chain Elongation 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-197264 Nicotinamide salvaging 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-181429 Serotonin Neurotransmitter Release Cycle 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-196757 Metabolism of folate and pterines 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-418457 cGMP effects 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-5635838 Activation of SMO 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-210993 Tie2 Signaling 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 1.00000000001187 1.18723049708395e-11 18 0 0 41 10285 R-HSA-139910 Activation of BMF and translocation to mitochondria 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5357572 Lysosomal glycogen catabolism 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-111458 Formation of apoptosome 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5624958 ARL13B-mediated ciliary trafficking of INPP5E 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-3359463 Defective CUBN causes hereditary megaloblastic anemia 1 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-163282 Mitochondrial transcription initiation 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-3296197 Hydroxycarboxylic acid-binding receptors 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-198745 Signalling to STAT3 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-190827 Transport of connexins along the secretory pathway 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-191647 c-src mediated regulation of Cx43 function and closure of gap junctions 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-2395516 Electron transport from NADPH to Ferredoxin 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-190704 Oligomerization of connexins into connexons 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-3304347 Loss of Function of SMAD4 in Cancer 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5688031 Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-351200 Interconversion of polyamines 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-193681 Ceramide signalling 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-110331 Cleavage of the damaged purine 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5653890 Lactose synthesis 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-8853336 Signaling by plasma membrane FGFR1 fusions 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-6806664 Metabolism of vitamin K 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-1368071 NR1D1 (REV-ERBA) represses gene expression 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5250989 Toxicity of botulinum toxin type G (BoNT/G) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-8849472 PTK6 Down-Regulation 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-8875791 MET activates STAT3 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-3249367 STAT6-mediated induction of chemokines 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-379397 Enzymatic degradation of dopamine by COMT 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5602680 MyD88 deficiency (TLR5) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-190374 FGFR1c and Klotho ligand binding and activation 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-444411 Rhesus glycoproteins mediate ammonium transport. 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-427589 Type II Na+/Pi cotransporters 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5250971 Toxicity of botulinum toxin type C (BoNT/C) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-1483248 Synthesis of PIPs at the ER membrane 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-352238 Breakdown of the nuclear lamina 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-165181 Inhibition of TSC complex formation by PKB 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-844615 The AIM2 inflammasome 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-3359462 Defective AMN causes hereditary megaloblastic anemia 1 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-77108 Utilization of Ketone Bodies 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-162699 Synthesis of dolichyl-phosphate mannose 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-844455 The NLRP1 inflammasome 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-977442 GABA A (rho) receptor activation 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-379398 Enzymatic degradation of Dopamine by monoamine oxidase 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-1299503 TWIK related potassium channel (TREK) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-1307965 betaKlotho-mediated ligand binding 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-265473 Trafficking of dietary sterols 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-380615 Serotonin clearance from the synaptic cleft 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-350864 Regulation of thyroid hormone activity 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-177539 Autointegration results in viral DNA circles 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-111446 Activation of BIM and translocation to mitochondria 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5339700 TCF7L2 mutants don't bind CTBP 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5627083 RHO GTPases regulate CFTR trafficking 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-175567 Integration of viral DNA into host genomic DNA 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-217271 FMO oxidises nucleophiles 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-392023 Adrenaline signalling through Alpha-2 adrenergic receptor 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5602571 TRAF3 deficiency - HSE 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-1296067 Potassium transport channels 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-5250992 Toxicity of botulinum toxin type E (BoNT/E) 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-191650 Regulation of gap junction activity 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-73927 Depurination 1.00000000001254 1.25354799860183e-11 3 0 0 41 10285 R-HSA-191859 snRNP Assembly 1.00000000001323 1.32294487331435e-11 53 0 0 41 10285 R-HSA-6806667 Metabolism of fat-soluble vitamins 1.00000000001323 1.32294487331435e-11 53 0 0 41 10285 R-HSA-72165 mRNA Splicing - Minor Pathway 1.00000000001323 1.32294487331435e-11 53 0 0 41 10285 R-HSA-194441 Metabolism of non-coding RNA 1.00000000001323 1.32294487331435e-11 53 0 0 41 10285 R-HSA-5620920 Cargo trafficking to the periciliary membrane 1.00000000001323 1.32294487331435e-11 53 0 0 41 10285 R-HSA-75153 Apoptotic execution phase 1.00000000001323 1.32294487331435e-11 53 0 0 41 10285 R-HSA-72163 mRNA Splicing - Major Pathway 1.00000000001449 1.44890054381954e-11 187 0 0 41 10285