Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

Enriched Categories

P-valueln(P)TermGO TreeGO ID# of Genes in Term# of Target Genes in Term# of Total Genes# of Target GenesCommon Genes
8.121e-24-53.17synapsecellular componentGO:00452021473321910850 SYT1,CAMK2B,NRXN3,DNM1,PPFIA3,PCLO,STX1A,CAMKV,GRIN2B,GRIN1,GRM5,CACNA1G,HCN1,CPLX1,NRG3,GABRB2,RIMS1,SLC4A10,SLC8A3,LRRC7,NRXN2,DLG4,CACNA1C,DLGAP2,SNAP25,SPTBN2,IQSEC2,CACNA1A,SCN8A,CAMK2A,CACNA1E,PPFIA2
1.444e-23-52.59Neuronal SystemREACTOME pathwaysR-HSA-112316349221028537 DLGAP2,CPLX1,CACNA2D1,SYT1,PPFIA3,GRIN1,CACNA1A,SNAP25,GRM5,CACNA1E,RIMS1,DLG4,CAMK2B,GRIN2B,HCN1,CAMK2A,PPFIA2,NRXN3,RASGRF1,GABRB2,STX1A,NRXN2
1.722e-22-50.11modulation of chemical synaptic transmissionbiological processGO:0050804494221820447 CAMK2B,SLC4A10,GRIN1,STX1A,IQSEC2,PPFIA2,CACNA1A,CAMK2A,GRM5,PPFIA3,RASGRF1,NRG3,SYT1,RIMS1,SNAP25,GRIN2B,DNM1,DLG4,SLC8A3,CAMKV,CPLX1,DLGAP2
1.799e-22-50.07regulation of trans-synaptic signalingbiological processGO:0099177495221820447 CAMK2B,GRM5,CAMK2A,IQSEC2,CACNA1A,PPFIA2,GRIN1,STX1A,SLC4A10,DNM1,GRIN2B,SYT1,NRG3,SNAP25,RIMS1,PPFIA3,RASGRF1,CPLX1,DLGAP2,SLC8A3,CAMKV,DLG4
1.035e-20-46.02cell junctioncellular componentGO:00300542224341910850 SLC4A10,SLC8A3,LRRC7,CACNA1G,HCN1,CPLX1,NRG3,GABRB2,RIMS1,DLGAP2,SNAP25,CAMK2A,SCN8A,IQSEC2,SPTBN2,CACNA1A,PPFIA2,CACNA1E,NRXN2,SPTBN4,DLG4,CACNA1C,NRXN3,CAMK2B,SYT1,STX1A,CAMKV,GRIN2B,GRIN1,GRM5,PPFIA3,L1CAM,DNM1,PCLO
1.901e-19-43.11Transmission across Chemical SynapsesREACTOME pathwaysR-HSA-112315217171028537 PPFIA2,GRIN2B,CAMK2A,RASGRF1,STX1A,GABRB2,SYT1,PPFIA3,CACNA2D1,CPLX1,DLG4,CAMK2B,CACNA1A,SNAP25,GRIN1,RIMS1,CACNA1E
2.152e-17-38.38cell projectioncellular componentGO:00429952398321910850 RASGRF1,SLC4A10,SLC8A3,LRRC7,HCN1,CPLX1,GABRB2,RIMS1,SNAP25,CACNA1A,SPTBN2,SCN8A,EPHA6,CAMK2A,PPFIA2,NRXN2,SPTBN4,DLG4,CACNA1C,BRINP1,CAMK2B,NRXN3,TMEM266,SYT1,STX1A,GRIN2B,ABLIM1,GRIN1,GRM5,DNM1,L1CAM,PCLO
1.064e-16-36.78synaptic membranecellular componentGO:0097060400171910850 NRXN3,LRRC7,HCN1,RIMS1,GABRB2,SYT1,SCN8A,STX1A,SNAP25,GRM5,GRIN1,GRIN2B,PPFIA2,NRXN2,DNM1,CACNA1C,DLG4
1.285e-16-36.59chemical synaptic transmissionbiological processGO:0007268415171820447 GRM5,CACNA1A,GRIN1,STX1A,GABRB2,PCLO,CACNA1E,CACNA1G,NRXN2,CPLX1,DLGAP2,DLG4,GRIN2B,SYT1,RIMS1,SNAP25,PPFIA3
1.285e-16-36.59anterograde trans-synaptic signalingbiological processGO:0098916415171820447 DLG4,DLGAP2,NRXN2,CPLX1,RIMS1,SNAP25,SYT1,PPFIA3,GRIN2B,GRIN1,STX1A,GABRB2,GRM5,CACNA1A,CACNA1G,PCLO,CACNA1E
1.802e-16-36.25cell-cell signalingbiological processGO:0007267822211820447 GRIN2B,SYT1,RIMS1,SNAP25,CACNA1C,PPFIA3,CPLX1,NRXN2,DLGAP2,FGF14,CACNA2D1,DLG4,PCLO,CACNA1E,RYR2,CACNA1G,GRM5,CACNA1A,STX1A,GRIN1,GABRB2
2.216e-16-36.05neuron projectioncellular componentGO:00430051331251910850 PCLO,L1CAM,GRIN2B,GRM5,GRIN1,STX1A,SYT1,TMEM266,BRINP1,CAMK2B,DLG4,CACNA1C,SPTBN4,PPFIA2,SNAP25,EPHA6,CAMK2A,SCN8A,GABRB2,HCN1,CPLX1,SLC8A3,LRRC7,RASGRF1,SLC4A10
2.413e-16-35.96trans-synaptic signalingbiological processGO:0099537431171820447 GABRB2,STX1A,GRIN1,CACNA1A,GRM5,CACNA1G,CACNA1E,PCLO,DLG4,CPLX1,NRXN2,DLGAP2,PPFIA3,SYT1,RIMS1,SNAP25,GRIN2B
6.862e-16-34.92synaptic signalingbiological processGO:0099536459171820447 CACNA1G,PCLO,CACNA1E,STX1A,GRIN1,GABRB2,GRM5,CACNA1A,SYT1,SNAP25,RIMS1,PPFIA3,GRIN2B,DLG4,NRXN2,CPLX1,DLGAP2
1.937e-15-33.88presynapsecellular componentGO:0098793569181910850 PCLO,DLG4,PPFIA3,NRXN2,DNM1,GRIN1,PPFIA2,SCN8A,SPTBN2,STX1A,SNAP25,RIMS1,SYT1,CPLX1,HCN1,NRXN3,SLC8A3,SLC4A10
2.297e-15-33.71regulation of biological qualitybiological processGO:00650082936321820447 CPLX1,CACNA2D1,CAMKV,DLG4,DNM1,SCN8A,RIMS1,CACNA1C,RASGRF1,PPFIA2,SLC4A10,PCLO,CAMK2B,RYR2,CACNA1G,SPTBN4,SLC8A3,GRIN2B,SNAP25,PPFIA3,GRM5,VSNL1,CAMK2A,IQSEC2,L1CAM,CACNA1A,STX1A,GRIN1,HCN1,GABRB2,SPTBN2,LRRC7
4.119e-15-33.12glutamatergic synapsecellular componentGO:0098978412161910850 HCN1,CPLX1,NRG3,SYT1,DNM1,NRXN2,PPFIA3,DLG4,PCLO,SNAP25,DLGAP2,CAMKV,SCN8A,SPTBN2,PPFIA2,GRM5
7.584e-15-32.51regulation of synaptic plasticitybiological processGO:0048167219131820447 SLC8A3,DLG4,GRIN2B,RIMS1,SNAP25,RASGRF1,PPFIA3,CAMK2A,GRM5,IQSEC2,GRIN1,SLC4A10,CAMK2B
1.733e-14-31.69postsynapsecellular componentGO:0098794646181910850 PCLO,CACNA1C,DLG4,SPTBN2,SCN8A,CAMK2A,DLGAP2,SNAP25,GRIN1,GRM5,PPFIA2,GRIN2B,CPLX1,HCN1,GABRB2,SLC4A10,LRRC7,SLC8A3
2.192e-14-31.45regulation of neuronal synaptic plasticitybiological processGO:00481685891820447 GRIN1,SLC4A10,DLG4,GRM5,CAMK2A,RASGRF1,PPFIA3,CAMK2B,GRIN2B
2.657e-14-31.26DGUOK (deoxyguanosine kinase)protein interactions171691101945450 L1CAM,STX1A,SYT1,CAMKV,CAMK2A,EDIL3,CAMK2B,DNM1,VSNL1,SNAP25
5.715e-14-30.49DNAAF2 (dynein axonemal assembly factor 2)protein interactions5517298101945450 STX1A,CAMK2A,SYT1,CAMKV,CACNA2D1,L1CAM,DNM1,SNAP25,VSNL1,CAMK2B
6.701e-14-30.33GPM6A (glycoprotein M6A)protein interactions2823143111945450 CAMK2B,VSNL1,SNAP25,DNM1,CACNA2D1,L1CAM,CAMKV,CAMK2A,SYT1,EDIL3,STX1A
8.097e-14-30.14Acetylcholine Neurotransmitter Release CycleREACTOME pathwaysR-HSA-2646421771028537 SNAP25,STX1A,RIMS1,PPFIA2,CPLX1,SYT1,PPFIA3
1.184e-13-29.76somatodendritic compartmentcellular componentGO:0036477842191910850 L1CAM,SPTBN4,CACNA1C,DLG4,EPHA6,CAMK2A,CACNA1A,SPTBN2,SNAP25,GRM5,GRIN1,CACNA1E,PPFIA2,CPLX1,TMEM266,HCN1,SLC4A10,SLC8A3,BRINP1
1.322e-13-29.65Norepinephrine Neurotransmitter Release CycleREACTOME pathwaysR-HSA-1814301871028537 PPFIA3,SYT1,CPLX1,PPFIA2,RIMS1,STX1A,SNAP25
1.322e-13-29.65Serotonin Neurotransmitter Release CycleREACTOME pathwaysR-HSA-1814291871028537 CPLX1,PPFIA3,SYT1,PPFIA2,RIMS1,STX1A,SNAP25
1.508e-13-29.52monoatomic ion channel complexcellular componentGO:0034702344141910850 HCN1,CACNA1G,RYR2,GABRB2,SNAP25,STX1A,CACNA2D1,CACNA1A,SCN8A,GRIN2B,CACNA1E,GRIN1,DLG4,CACNA1C
3.321e-13-28.73Interactions of neurexins and neuroligins at synapsesREACTOME pathwaysR-HSA-67943615891028537 GRIN2B,DLGAP2,NRXN3,SYT1,GRM5,GRIN1,STX1A,DLG4,NRXN2
1.005e-12-27.63Dopamine Neurotransmitter Release CycleREACTOME pathwaysR-HSA-2126762371028537 SNAP25,STX1A,RIMS1,PPFIA2,CPLX1,SYT1,PPFIA3
1.391e-12-27.30NUFIP1 (nuclear FMR1 interacting protein 1)protein interactions26747134101945450 CAMK2B,VSNL1,SNAP25,DNM1,L1CAM,CAMKV,CAMK2A,SYT1,EDIL3,STX1A
1.415e-12-27.28Glutamate Neurotransmitter Release CycleREACTOME pathwaysR-HSA-2105002471028537 STX1A,RIMS1,SNAP25,CPLX1,SYT1,PPFIA3,PPFIA2
2.255e-12-26.82calcium ion transmembrane import into cytosolbiological processGO:00975539591820447 CACNA2D1,SLC8A3,GRIN1,CACNA1A,RYR2,CACNA1G,CACNA1C,CACNA1E,GRIN2B
2.564e-12-26.69Protein-protein interactions at synapsesREACTOME pathwaysR-HSA-67943627291028537 SYT1,NRXN3,DLGAP2,GRIN2B,DLG4,NRXN2,STX1A,GRM5,GRIN1
3.364e-12-26.42postsynaptic specializationcellular componentGO:0099572345131910850 LRRC7,GRIN1,GRM5,SLC8A3,GRIN2B,PPFIA2,CAMK2A,SCN8A,DLGAP2,GABRB2,CACNA1C,PCLO,DLG4
3.515e-12-26.37transmembrane transporter complexcellular componentGO:1902495434141910850 CACNA1A,SCN8A,SNAP25,STX1A,CACNA2D1,GRIN1,GRIN2B,CACNA1E,CACNA1C,DLG4,RYR2,HCN1,CACNA1G,GABRB2
4.291e-12-26.17cation channel complexcellular componentGO:0034703205111910850 CACNA1E,CACNA1A,SCN8A,SNAP25,CACNA2D1,STX1A,CACNA1C,DLG4,RYR2,CACNA1G,HCN1
4.498e-12-26.13axoncellular componentGO:0030424650161910850 HCN1,CPLX1,SYT1,RASGRF1,SLC4A10,SLC8A3,LRRC7,L1CAM,SPTBN4,DLG4,PCLO,STX1A,SNAP25,SCN8A,PPFIA2,GRIN1
6.168e-12-25.81plasma membrane bounded cell projectioncellular componentGO:01200252285261910850 SLC8A3,LRRC7,RASGRF1,SLC4A10,GABRB2,HCN1,CPLX1,PPFIA2,SNAP25,SCN8A,CAMK2A,EPHA6,DLG4,CACNA1C,SPTBN4,BRINP1,CAMK2B,SYT1,TMEM266,ABLIM1,GRIN2B,GRM5,GRIN1,STX1A,PCLO,L1CAM
6.189e-12-25.81regulation of membrane potentialbiological processGO:0042391463141820447 CACNA1C,RIMS1,SCN8A,GRIN2B,CACNA2D1,SLC8A3,DLG4,RYR2,CACNA1G,GRIN1,STX1A,HCN1,GABRB2,GRM5
7.895e-12-25.56transporter complexcellular componentGO:1990351461141910850 GABRB2,RYR2,CACNA1G,HCN1,CACNA1C,DLG4,GRIN1,CACNA1E,GRIN2B,CACNA1A,SCN8A,SNAP25,STX1A,CACNA2D1
1.587e-11-24.87Axon guidanceREACTOME pathwaysR-HSA-422475549161028537 SPTBN2,SCN8A,GRIN1,SPTBN4,NRG3,DLG4,EPHA6,CAMK2B,CACNA1G,ABLIM1,GRIN2B,CAMK2A,DNM1,RASGRF1,L1CAM,CACNA1C
1.599e-11-24.86presynaptic membranecellular componentGO:0042734168101910850 NRXN3,PPFIA2,SCN8A,STX1A,SNAP25,RIMS1,SYT1,NRXN2,DNM1,HCN1
2.769e-11-24.31presynaptic active zonecellular componentGO:00487867981910850 HCN1,PPFIA3,PCLO,RIMS1,SCN8A,SNAP25,STX1A,PPFIA2
2.928e-11-24.25voltage-gated channel activitymolecular functionGO:0022832173101809449 CACNA2D1,CACNA1A,CACNA1G,CACNA1E,HCN1,GRIN1,GRIN2B,SNAP25,CACNA1C,TMEM266
3.392e-11-24.11synapse organizationbiological processGO:0050808333121820447 PPFIA2,L1CAM,GRM5,GABRB2,SPTBN2,PCLO,SPTBN4,NRXN2,DLG4,SLC8A3,PPFIA3,NRG3
3.715e-11-24.02Ras activation uopn Ca2+ infux through NMDA receptorREACTOME pathwaysR-HSA-4429821961028537 RASGRF1,GRIN1,DLG4,CAMK2B,GRIN2B,CAMK2A
3.916e-11-23.96gated channel activitymolecular functionGO:0022836320121809449 RYR2,TMEM266,GRIN1,HCN1,GRIN2B,GABRB2,CACNA1C,SNAP25,CACNA1E,CACNA2D1,CACNA1A,CACNA1G
5.810e-11-23.57neurotransmitter secretionbiological processGO:00072698881820447 STX1A,CPLX1,NRXN2,PPFIA3,SYT1,RIMS1,SNAP25,PCLO
5.810e-11-23.57signal release from synapsebiological processGO:00996438881820447 SYT1,SNAP25,RIMS1,PPFIA3,PCLO,STX1A,CPLX1,NRXN2
7.677e-11-23.29calcium ion import across plasma membranebiological processGO:00987032861820447 CACNA1A,SLC8A3,CACNA2D1,CACNA1E,CACNA1G,CACNA1C
9.334e-11-23.09calcium ion transmembrane transporter activitymolecular functionGO:001508513691809449 CACNA1C,RYR2,GRIN1,GRIN2B,CACNA1E,CACNA2D1,CACNA1A,SLC8A3,CACNA1G
9.660e-11-23.06calcium ion import into cytosolbiological processGO:19026562961820447 CACNA1A,CACNA1E,CACNA1C,CACNA1G,CACNA2D1,SLC8A3
1.093e-10-22.94metal ion transmembrane transporter activitymolecular functionGO:0046873442131809449 CACNA1G,SLC8A3,CACNA1A,CACNA2D1,CACNA1E,SNAP25,CACNA1C,GRIN1,HCN1,GRIN2B,SCN8A,SLC4A10,RYR2
1.246e-10-22.81neuron to neuron synapsecellular componentGO:0098984365121910850 GRIN1,GRM5,GRIN2B,SCN8A,CAMK2A,DLGAP2,PCLO,CACNA1C,DLG4,LRRC7,SLC8A3,SYT1
1.738e-10-22.47plasma membrane regioncellular componentGO:00985901278191910850 GRM5,GRIN1,PPFIA2,GRIN2B,SCN8A,SPTBN2,SNAP25,STX1A,CACNA1C,DLG4,DNM1,NRXN2,LRRC7,NRXN3,SLC4A10,SYT1,GABRB2,RIMS1,HCN1
2.159e-10-22.26positive regulation of synaptic transmissionbiological processGO:005080615791820447 GRIN2B,RIMS1,SNAP25,SYT1,IQSEC2,DLG4,STX1A,GRIN1,SLC8A3
2.379e-10-22.16synaptic vesicle exocytosisbiological processGO:00160796371820447 PCLO,SNAP25,RIMS1,SYT1,PPFIA3,CPLX1,STX1A
2.894e-10-21.96behaviorbiological processGO:0007610619141820447 BRINP1,DLG4,SLC4A10,HCN1,SLC8A3,GRIN1,SPTBN4,GRM5,NRXN2,RASGRF1,NRXN3,SNAP25,SPTBN2,GRIN2B
3.643e-10-21.73metal ion transportbiological processGO:0030001630141820447 RYR2,CACNA1G,SNAP25,CACNA1C,CACNA1E,GRIN2B,SCN8A,SLC4A10,HCN1,SLC8A3,CACNA2D1,GRIN1,CACNA1A,CAMK2A
4.418e-10-21.54Neurotransmitter Release CycleREACTOME pathwaysR-HSA-1123105171028537 RIMS1,STX1A,SNAP25,SYT1,PPFIA3,CPLX1,PPFIA2
4.627e-10-21.49postsynaptic densitycellular componentGO:0014069317111910850 CACNA1C,PCLO,DLG4,CAMK2A,SCN8A,DLGAP2,GRIN1,GRM5,LRRC7,SLC8A3,GRIN2B
5.215e-10-21.37channel activitymolecular functionGO:0015267502131809449 CACNA1C,GABRB2,SNAP25,CACNA1E,CACNA1G,CACNA1A,CACNA2D1,TMEM266,RYR2,SCN8A,GRIN1,GRIN2B,HCN1
5.343e-10-21.35passive transmembrane transporter activitymolecular functionGO:0022803503131809449 CACNA1A,CACNA2D1,CACNA1G,CACNA1E,SNAP25,CACNA1C,GABRB2,GRIN1,HCN1,GRIN2B,SCN8A,RYR2,TMEM266
5.350e-10-21.35nervous system developmentbiological processGO:00073992185231820447 RASGRF1,NRG3,SCN8A,BRINP1,DLG4,FGF14,NRXN2,CAMK2B,PCLO,SLC4A10,SNAP25,GRIN2B,MYT1L,SLC8A3,SPTBN4,NRXN3,SPTBN2,GABRB2,HCN1,GRIN1,EPHA6,L1CAM,CAMK2A
6.338e-10-21.18CREB phosphorylation through the activation of RasREACTOME pathwaysR-HSA-4427422961028537 GRIN1,GRIN2B,RASGRF1,CAMK2A,DLG4,CAMK2B
6.870e-10-21.10calcium ion transportbiological processGO:0006816251101820447 CAMK2A,CACNA1A,SLC8A3,CACNA2D1,GRIN1,CACNA1E,GRIN2B,RYR2,CACNA1C,CACNA1G
7.231e-10-21.05voltage-gated monoatomic ion channel activitymolecular functionGO:000524417191809449 SNAP25,CACNA1C,CACNA1A,CACNA2D1,CACNA1G,CACNA1E,GRIN1,HCN1,GRIN2B
7.642e-10-20.99calcium ion importbiological processGO:00705094061820447 CACNA1E,CACNA1G,CACNA1C,CACNA1A,CACNA2D1,SLC8A3
7.782e-10-20.97asymmetric synapsecellular componentGO:0032279333111910850 PCLO,CACNA1C,DLG4,GRM5,LRRC7,GRIN1,GRIN2B,SLC8A3,SCN8A,CAMK2A,DLGAP2
8.674e-10-20.87calcium channel activitymolecular functionGO:000526211781809449 GRIN2B,GRIN1,CACNA1E,CACNA1G,CACNA1A,CACNA2D1,RYR2,CACNA1C
1.020e-09-20.70monoatomic cation channel activitymolecular functionGO:0005261331111809449 CACNA1G,CACNA2D1,CACNA1A,CACNA1E,HCN1,GRIN1,GRIN2B,SCN8A,SNAP25,CACNA1C,RYR2
1.237e-09-20.51Synaptic Vesicle PathwayWikiPathwaysWP2267527531023 CPLX1,STX1A,DNM1,SYT1,CACNA1A,SNAP25,RIMS1
1.314e-09-20.45regulation of system processbiological processGO:0044057571131820447 STX1A,GRIN1,CAMK2B,CACNA1G,RYR2,DLGAP2,SPTBN4,SLC8A3,CACNA2D1,DLG4,GRIN2B,CACNA1C,RIMS1
1.544e-09-20.29monoatomic ion channel activitymolecular functionGO:0005216441121809449 CACNA1G,CACNA2D1,CACNA1A,GRIN2B,HCN1,GRIN1,CACNA1E,SCN8A,SNAP25,GABRB2,CACNA1C,RYR2
1.610e-09-20.25Calcium signaling pathwayKEGG pathwaysko0402018110716130 GRM5,GRIN1,CACNA1G,CAMK2A,CACNA1E,CAMK2B,SLC8A3,RYR2,CACNA1A,CACNA1C
1.610e-09-20.25Calcium signaling pathwayKEGG pathwayshsa0402018110716130 CAMK2A,CACNA1G,CACNA1E,GRM5,GRIN1,CACNA1A,CACNA1C,SLC8A3,CAMK2B,RYR2
1.723e-09-20.18learning or memorybiological processGO:0007611276101820447 SLC8A3,GRIN1,DLG4,BRINP1,GRM5,NRXN2,NRXN3,SNAP25,RASGRF1,GRIN2B
1.880e-09-20.09inorganic ion transmembrane transportbiological processGO:0098660715141820447 GRIN2B,SCN8A,CACNA1C,SNAP25,CACNA2D1,SLC8A3,CACNA1E,CACNA1G,RYR2,CACNA1A,GABRB2,HCN1,SLC4A10,GRIN1
1.961e-09-20.05NCAM signaling for neurite out-growthREACTOME pathwaysR-HSA-375165276111028537 RASGRF1,CACNA1C,GRIN2B,CACNA1G,CAMK2A,GRIN1,NRG3,SPTBN4,DLG4,CAMK2B,SPTBN2
2.299e-09-19.89calcium ion transmembrane transportbiological processGO:007058820591820447 GRIN2B,CACNA1E,CACNA1C,CACNA1G,RYR2,CACNA1A,GRIN1,SLC8A3,CACNA2D1
2.443e-09-19.83neurotransmitter transportbiological processGO:000683614081820447 SYT1,SNAP25,RIMS1,PPFIA3,PCLO,STX1A,NRXN2,CPLX1
2.701e-09-19.73soft_tissue-blood_vessel-angiosarcomaCOSMIC cancer mutationssoft_tissue-blood_vessel-angiosarcoma2192231682847 CACNA1C,EDIL3,CAMK2B,SLC8A3,NRG3,GRIN2B,RYR2,CACNA1E,L1CAM,NRXN3,CACNA2D1,MCF2L2,PCLO,RIMS1,CAMK2A,LRRC7,DLGAP2,EPHA6,NRXN2,PPFIA2,CACNA1G,FGF14,HCN1
2.701e-09-19.73angiosarcomaCOSMIC cancer mutationsangiosarcoma2192231682847 RYR2,HCN1,CACNA1E,L1CAM,CACNA2D1,NRXN3,PCLO,MCF2L2,RIMS1,CACNA1C,EDIL3,CAMK2A,DLGAP2,LRRC7,CAMK2B,EPHA6,NRXN2,NRG3,SLC8A3,FGF14,GRIN2B,PPFIA2,CACNA1G
2.729e-09-19.72CREB phosphorylation through the activation of CaMKIIREACTOME pathwaysR-HSA-4427291751028537 DLG4,CAMK2B,GRIN1,GRIN2B,CAMK2A
2.729e-09-19.72Unblocking of NMDA receptor, glutamate binding and activationREACTOME pathwaysR-HSA-4380661751028537 CAMK2B,DLG4,CAMK2A,GRIN2B,GRIN1
2.736e-09-19.72modulation of excitatory postsynaptic potentialbiological processGO:00988154961820447 DLG4,STX1A,GRIN1,SLC8A3,RIMS1,GRIN2B
3.038e-09-19.61Post NMDA receptor activation eventsREACTOME pathwaysR-HSA-4380643761028537 CAMK2A,GRIN2B,GRIN1,RASGRF1,CAMK2B,DLG4
3.055e-09-19.61synaptic vesicle cyclebiological processGO:009950414481820447 CPLX1,STX1A,DNM1,PCLO,PPFIA3,RIMS1,SNAP25,SYT1
3.202e-09-19.56blood_vesselCOSMIC cancer mutationsblood_vessel2211231682847 HCN1,CAMK2A,LRRC7,DLGAP2,EPHA6,NRXN2,PPFIA2,CACNA1G,FGF14,RYR2,CACNA1E,L1CAM,NRXN3,CACNA2D1,MCF2L2,PCLO,RIMS1,CACNA1C,EDIL3,CAMK2B,SLC8A3,NRG3,GRIN2B
3.414e-09-19.50inorganic cation transmembrane transportbiological processGO:0098662618131820447 HCN1,SLC4A10,GRIN1,SLC8A3,CACNA2D1,CACNA1A,CACNA1G,SNAP25,CACNA1C,RYR2,GRIN2B,CACNA1E,SCN8A
3.463e-09-19.48neuronal cell bodycellular componentGO:0043025489121910850 SLC4A10,SLC8A3,BRINP1,TMEM266,CPLX1,SPTBN2,CACNA1A,SNAP25,CACNA1E,SPTBN4,L1CAM,CACNA1C
3.616e-09-19.44inorganic cation transmembrane transporter activitymolecular functionGO:0022890589131809449 CACNA1A,CACNA2D1,SLC8A3,CACNA1G,CACNA1E,SNAP25,CACNA1C,HCN1,GRIN1,GRIN2B,SLC4A10,SCN8A,RYR2
3.664e-09-19.42inorganic molecular entity transmembrane transporter activitymolecular functionGO:0015318714141809449 RYR2,SLC4A10,SCN8A,GRIN2B,GRIN1,HCN1,GABRB2,CACNA1C,SNAP25,CACNA1E,CACNA2D1,CACNA1A,SLC8A3,CACNA1G
4.133e-09-19.30GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)protein interactions29029471945450 DNM1,GRIN1,DLG4,CAMK2A,GRIN2B,CACNA2D1,GRM5
4.550e-09-19.21monoatomic cation transportbiological processGO:0006812766141820447 CAMK2A,CACNA1A,GRIN1,HCN1,SLC4A10,CACNA1E,CACNA1G,RYR2,CACNA2D1,SLC8A3,SCN8A,GRIN2B,CACNA1C,SNAP25
4.588e-09-19.20dendritecellular componentGO:0030425620131910850 GRIN1,GRM5,PPFIA2,CAMK2A,EPHA6,CACNA1C,DLG4,L1CAM,BRINP1,SLC8A3,SLC4A10,TMEM266,HCN1
4.667e-09-19.18RIMS1 (regulating synaptic membrane exocytosis 1)protein interactions229992551945450 CAMK2A,SYT1,SNAP25,CACNA1C,STX1A
4.712e-09-19.17cell peripherycellular componentGO:00719446020361910850 NRXN3,TMEM266,RYR2,SYT1,STX1A,CACNA2D1,CAMKV,GRIN2B,GRM5,GRIN1,DNM1,L1CAM,PPFIA3,PCLO,RASGRF1,SLC4A10,SLC8A3,LRRC7,HCN1,CACNA1G,NRG3,GABRB2,RIMS1,EDIL3,SNAP25,DLGAP2,CACNA1A,SPTBN2,SCN8A,EPHA6,PPFIA2,CACNA1E,SPTBN4,NRXN2,DLG4,CACNA1C
4.769e-09-19.16dendritic treecellular componentGO:0097447622131910850 L1CAM,DLG4,CACNA1C,EPHA6,CAMK2A,PPFIA2,GRIN1,GRM5,HCN1,TMEM266,SLC4A10,BRINP1,SLC8A3
4.820e-09-19.15monoatomic cation transmembrane transportbiological processGO:0098655636131820447 SLC8A3,CACNA2D1,CACNA1C,SNAP25,GRIN2B,SCN8A,SLC4A10,HCN1,GRIN1,CACNA1A,RYR2,CACNA1G,CACNA1E
5.034e-09-19.11Synaptic vesicle cycleKEGG pathwayshsa04721637716130 SNAP25,RIMS1,SYT1,DNM1,STX1A,CPLX1,CACNA1A
5.034e-09-19.11Synaptic vesicle cycleKEGG pathwaysko04721637716130 RIMS1,SYT1,CPLX1,STX1A,CACNA1A,SNAP25,DNM1
5.101e-09-19.09GABA synthesis, release, reuptake and degradationREACTOME pathwaysR-HSA-8885901951028537 SNAP25,RIMS1,STX1A,CPLX1,SYT1
5.196e-09-19.08vesicle-mediated transport in synapsebiological processGO:009900315481820447 PPFIA3,SNAP25,RIMS1,SYT1,DNM1,PCLO,STX1A,CPLX1
5.394e-09-19.04VDCCAlpha1interpro domainsIPR002077941852149 CACNA1C,CACNA1G,CACNA1A,CACNA1E
5.816e-09-18.96Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOME pathwaysR-HSA-4427554161028537 GRIN2B,GRIN1,RASGRF1,CAMK2A,DLG4,CAMK2B
6.917e-09-18.79cognitionbiological processGO:0050890319101820447 GRIN2B,RASGRF1,SNAP25,NRXN3,NRXN2,GRM5,BRINP1,DLG4,GRIN1,SLC8A3
7.058e-09-18.77cell junction organizationbiological processGO:0034330532121820447 SPTBN2,PCLO,PPFIA3,NRG3,L1CAM,PPFIA2,SPTBN4,NRXN2,GRM5,GABRB2,DLG4,SLC8A3
7.101e-09-18.76monoatomic ion transmembrane transporter activitymolecular functionGO:0015075752141809449 SNAP25,GABRB2,CACNA1C,SLC8A3,CACNA1A,CACNA2D1,CACNA1G,CACNA1E,SCN8A,SLC4A10,RYR2,GRIN2B,GRIN1,HCN1
7.729e-09-18.68GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B)protein interactions29045861945450 GRIN1,RASGRF1,CAMK2B,DLG4,GRIN2B,CAMK2A
8.095e-09-18.63monoatomic cation transmembrane transporter activitymolecular functionGO:0008324630131809449 SNAP25,CACNA1C,CACNA1G,CACNA1A,SLC8A3,CACNA2D1,CACNA1E,SCN8A,SLC4A10,RYR2,HCN1,GRIN2B,GRIN1
8.155e-09-18.62haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma3511281682847 NRG3,VSNL1,GRM5,CAMK2B,EDIL3,CACNA1C,SLC4A10,SPTBN2,CACNA2D1,NRXN3,CACNA1A,RIMS1,PCLO,GRIN1,MCF2L2,CACNA1E,SYT1,RYR2,PPFIA2,CACNA1G,NRXN2,GABRB2,CELF5,EPHA6,DNM1,SCN8A,HCN1,MYT1L
8.155e-09-18.62chronic_lymphocytic_leukaemia-small_lymphocytic_lymphomaCOSMIC cancer mutationschronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma3511281682847 MYT1L,HCN1,SCN8A,DNM1,EPHA6,GABRB2,CELF5,CACNA1G,PPFIA2,NRXN2,SYT1,CACNA1E,RYR2,CACNA1A,RIMS1,MCF2L2,GRIN1,PCLO,CACNA2D1,NRXN3,SPTBN2,CAMK2B,CACNA1C,SLC4A10,EDIL3,GRM5,VSNL1,NRG3
8.432e-09-18.59monoatomic ion transmembrane transportbiological processGO:0034220804141820447 SCN8A,GRIN2B,SNAP25,CACNA1C,SLC8A3,CACNA2D1,CACNA1E,RYR2,CACNA1G,CACNA1A,GRIN1,SLC4A10,HCN1,GABRB2
9.873e-09-18.43monoatomic ion transportbiological processGO:0006811964151820447 CACNA2D1,SLC8A3,CACNA1C,SNAP25,GRIN2B,SCN8A,SLC4A10,HCN1,GABRB2,GRIN1,CACNA1A,CAMK2A,RYR2,CACNA1G,CACNA1E
1.367e-08-18.11Phase 0 - rapid depolarisationREACTOME pathwaysR-HSA-55768924761028537 SCN8A,CACNA2D1,CAMK2A,FGF14,CAMK2B,CACNA1C
1.369e-08-18.11Ion_transpfam domainsPF0052010971779547 RYR2,CACNA1A,SCN8A,CACNA1G,CACNA1C,HCN1,CACNA1E
1.403e-08-18.08establishment of localizationbiological processGO:00512343887281820447 SLC4A10,PPFIA2,RYR2,CACNA1G,PCLO,CACNA1E,CACNA2D1,DLG4,CPLX1,NRXN2,SYT1,RIMS1,CACNA1C,DNM1,SCN8A,STX1A,GRIN1,HCN1,GABRB2,CAMK2A,CACNA1A,LRRC7,SPTBN2,SLC8A3,SPTBN4,SNAP25,PPFIA3,GRIN2B
1.410e-08-18.08Ion_trans_dominterpro domainsIPR00582110971852149 CACNA1G,RYR2,CACNA1E,CACNA1A,HCN1,SCN8A,CACNA1C
1.450e-08-18.05cell bodycellular componentGO:0044297556121910850 CACNA1E,CACNA1A,SPTBN2,SNAP25,CACNA1C,L1CAM,SPTBN4,BRINP1,SLC8A3,SLC4A10,CPLX1,TMEM266
1.484e-08-18.03transportbiological processGO:00068103615271820447 CACNA1A,CAMK2A,GABRB2,HCN1,STX1A,GRIN1,SPTBN2,LRRC7,SPTBN4,SLC8A3,GRIN2B,PPFIA3,SNAP25,PPFIA2,SLC4A10,CACNA1E,PCLO,RYR2,CACNA1G,CPLX1,NRXN2,CACNA2D1,DNM1,SCN8A,SYT1,RIMS1,CACNA1C
1.514e-08-18.01Volt_channel_dom_sfinterpro domainsIPR0273596361852149 CACNA1G,TMEM266,CACNA1E,CACNA1A,SCN8A,CACNA1C
1.627e-08-17.93upper_aerodigestive_tract-mouth-carcinomaCOSMIC cancer mutationsupper_aerodigestive_tract-mouth-carcinoma6426371682847 GRIN2B,NRG3,SLC8A3,GRM5,CCDC136,SLC4A10,EDIL3,CACNA1C,SPTBN2,CELF3,RIMS1,CACNA1A,PCLO,MCF2L2,RASGRF1,GRIN1,DLG4,CACNA1E,SYT1,RYR2,L1CAM,CACNA1G,PPFIA2,NRXN2,ABLIM1,DLGAP2,LRRC7,CELF5,CAMK2A,EPHA6,DNM1,PPFIA3,SCN8A,SNAP25,SPTBN4,HCN1,MYT1L
1.761e-08-17.85positive regulation of excitatory postsynaptic potentialbiological processGO:20004633251820447 DLG4,RIMS1,GRIN1,STX1A,GRIN2B
1.766e-08-17.85transmembrane transporter activitymolecular functionGO:00228571110161809449 RYR2,TMEM266,SCN8A,SLC4A10,GRIN2B,HCN1,GRIN1,GABRB2,CACNA1C,SNAP25,CPLX1,CACNA1E,CACNA1A,SLC8A3,CACNA2D1,CACNA1G
1.941e-08-17.76CACHANNELprints domainsPR0016794522720 CACNA1A,CACNA1G,CACNA1E,CACNA1C
2.292e-08-17.59regulation of nervous system processbiological processGO:003164412071820447 GRIN2B,RIMS1,DLGAP2,SLC8A3,STX1A,GRIN1,DLG4
2.484e-08-17.51signal releasebiological processGO:002306118881820447 NRXN2,CPLX1,STX1A,PCLO,SNAP25,RIMS1,SYT1,PPFIA3
2.645e-08-17.45-gene3d domains1.10.287.7014881447048 CACNA1A,CACNA1C,HCN1,SCN8A,CACNA1E,GRIN1,CACNA1G,RYR2
2.718e-08-17.42calcium channel complexcellular componentGO:00347047061910850 CACNA1A,RYR2,CACNA1G,CACNA2D1,CACNA1C,CACNA1E
2.903e-08-17.35GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A)protein interactions29037261945450 CAMK2A,GRIN2B,GRM5,GRIN1,DLG4,CAMK2B
2.983e-08-17.33Cardiac conductionREACTOME pathwaysR-HSA-557689114281028537 FGF14,CAMK2B,CACNA1C,SCN8A,RYR2,CACNA2D1,CAMK2A,SLC8A3
3.359e-08-17.21plasma membrane protein complexcellular componentGO:0098797600121910850 CACNA1G,HCN1,GRIN1,CACNA1E,GRIN2B,CACNA1A,SCN8A,STX1A,CACNA2D1,SNAP25,CACNA1C,DLG4
3.510e-08-17.17system processbiological processGO:00030082015201820447 NRXN3,RYR2,CACNA1G,GRM5,ABLIM1,SLC4A10,HCN1,GRIN1,GRIN2B,SCN8A,RASGRF1,SNAP25,CACNA1C,RIMS1,SPTBN4,NRXN2,BRINP1,DLG4,CACNA2D1,SLC8A3
3.542e-08-17.16haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma981151682847 EPHA6,EDIL3,CAMK2A,DLGAP2,GABRB2,NRG3,GRIN2B,FGF14,PPFIA2,RYR2,SYT1,PCLO,CACNA1A,NRXN3,CACNA2D1
3.905e-08-17.06Developmental BiologyREACTOME pathwaysR-HSA-12667381075171028537 STX1A,L1CAM,DNM1,RASGRF1,CACNA1C,CAMK2A,GRIN2B,ABLIM1,CACNA1G,NRG3,SPTBN4,GRIN1,CAMK2B,DLG4,EPHA6,SPTBN2,SCN8A
4.058e-08-17.02postsynaptic membranecellular componentGO:004521128091910850 SCN8A,GRIN2B,GRIN1,LRRC7,GRM5,HCN1,DLG4,CACNA1C,GABRB2
4.176e-08-16.99regulation of transportbiological processGO:00510491621181820447 SYT1,SNAP25,RIMS1,CACNA1C,GRIN2B,DLG4,CACNA2D1,SPTBN4,FGF14,CPLX1,RYR2,CAMK2B,PCLO,STX1A,GRIN1,PPFIA2,CAMK2A,VSNL1
4.220e-08-16.98Insulin secretionKEGG pathwayshsa04911857716130 SNAP25,CAMK2B,RYR2,CACNA1C,STX1A,CAMK2A,PCLO
4.327e-08-16.96oesophagus-lower_third-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsoesophagus-lower_third-carcinoma-squamous_cell_carcinoma3507271682847 RIMS1,GRIN1,RASGRF1,MCF2L2,PCLO,NRXN3,CACNA1E,RYR2,GRM5,GRIN2B,SPTBN2,CELF3,CACNA1C,SLC4A10,PPFIA3,SCN8A,MYT1L,SPTBN4,HCN1,PPFIA2,CACNA1G,NRXN2,EPHA6,LRRC7,DLGAP2,CAMK2A,CELF5
4.657e-08-16.88high voltage-gated calcium channel activitymolecular functionGO:00083311441809449 CACNA1C,CACNA1E,CACNA1A,CACNA1G
4.847e-08-16.84system developmentbiological processGO:00487313533261820447 SNAP25,GRIN2B,SLC8A3,MYT1L,SPTBN4,NRXN3,SPTBN2,GRIN1,HCN1,GABRB2,CAMK2A,L1CAM,EPHA6,CACNA1C,NRG3,RASGRF1,SCN8A,BRINP1,DLG4,NRXN2,FGF14,CACNA1G,RYR2,PCLO,CAMK2B,SLC4A10
5.680e-08-16.68Voltage-gated potassium channels. Chain Cgene3d domains1.20.120.3506361447048 CACNA1E,SCN8A,CACNA1A,TMEM266,CACNA1C,CACNA1G
5.979e-08-16.63transporter activitymolecular functionGO:00052151211161809449 SNAP25,CACNA1C,GABRB2,CACNA2D1,SLC8A3,CACNA1A,CACNA1G,CACNA1E,CPLX1,SLC4A10,SCN8A,RYR2,TMEM266,GRIN2B,HCN1,GRIN1
6.243e-08-16.59plasma membranecellular componentGO:00058865538331910850 DNM1,L1CAM,GRIN2B,GRIN1,GRM5,CACNA2D1,CAMKV,STX1A,SYT1,TMEM266,RYR2,NRXN3,DLG4,CACNA1C,NRXN2,SPTBN4,CACNA1E,PPFIA2,DLGAP2,SNAP25,SPTBN2,CACNA1A,SCN8A,EPHA6,NRG3,RIMS1,GABRB2,HCN1,CACNA1G,SLC8A3,LRRC7,RASGRF1,SLC4A10
6.428e-08-16.56regulation of neurotransmitter secretionbiological processGO:00469288261820447 SYT1,RIMS1,STX1A,CPLX1,CAMK2A,PPFIA2
6.813e-08-16.50membrane protein complexcellular componentGO:00987961261161910850 DLG4,CACNA1C,DNM1,CACNA1E,GRIN2B,GRIN1,SNAP25,STX1A,CACNA2D1,CACNA1A,SCN8A,GABRB2,CACNA1G,HCN1,CPLX1,RYR2
7.445e-08-16.41calmodulin bindingmolecular functionGO:000551620681809449 SLC8A3,CAMK2B,GRIN1,CAMKV,SYT1,CAMK2A,RYR2,CACNA1C
8.081e-08-16.33regulated exocytosisbiological processGO:004505514471820447 STX1A,CPLX1,SNAP25,RIMS1,SYT1,PPFIA3,PCLO
8.158e-08-16.32follicular_lymphomaCOSMIC cancer mutationsfollicular_lymphoma1209161682847 EPHA6,EDIL3,CAMK2A,DLGAP2,GABRB2,NRG3,GRIN2B,FGF14,PPFIA2,RYR2,SPTBN4,SYT1,PCLO,CACNA1A,NRXN3,CACNA2D1
9.316e-08-16.19voltage-gated calcium channel activitymolecular functionGO:00052454251809449 CACNA1E,CACNA1C,CACNA1G,CACNA2D1,CACNA1A
9.877e-08-16.13Circadian entrainmentKEGG pathwayshsa04713967716130 CACNA1C,CACNA1G,CAMK2A,GRIN1,RYR2,GRIN2B,CAMK2B
9.877e-08-16.13Circadian entrainmentKEGG pathwaysko04713967716130 GRIN1,CACNA1G,CAMK2A,GRIN2B,RYR2,CAMK2B,CACNA1C
1.042e-07-16.08cardiac muscle cell action potential involved in contractionbiological processGO:00860024551820447 SCN8A,CACNA2D1,RYR2,CACNA1G,CACNA1C
1.082e-07-16.04voltage-gated monoatomic cation channel activitymolecular functionGO:002284314371809449 HCN1,CACNA1E,CACNA1G,CACNA1A,CACNA2D1,CACNA1C,SNAP25
1.096e-07-16.03multicellular organism developmentbiological processGO:00072753957271820447 SLC4A10,CAMK2B,PCLO,RYR2,CACNA1G,FGF14,NRXN2,DLG4,BRINP1,SCN8A,RASGRF1,NRG3,CACNA1C,L1CAM,EPHA6,CAMK2A,GABRB2,HCN1,GRIN1,SPTBN2,LRRC7,NRXN3,SPTBN4,MYT1L,SLC8A3,GRIN2B,SNAP25
1.128e-07-16.00voltage-gated calcium channel complexcellular componentGO:00058914551910850 CACNA1A,CACNA1G,CACNA2D1,CACNA1C,CACNA1E
1.128e-07-16.00intestinal_adenocarcinomaCOSMIC cancer mutationsintestinal_adenocarcinoma7225381682847 EPHA6,CAMK2A,STX1A,GABRB2,LRRC7,DLGAP2,NRXN2,PPFIA2,CACNA1G,FGF14,IQSEC2,MYT1L,HCN1,SPTBN4,PPFIA3,SCN8A,DNM1,SPTBN2,CACNA1C,EDIL3,SLC4A10,CAMK2B,CCDC136,GRM5,SLC8A3,NRG3,GRIN2B,L1CAM,RYR2,SYT1,CACNA1E,MCF2L2,RASGRF1,PCLO,CACNA1A,RIMS1,CACNA2D1,NRXN3
1.128e-07-16.00stomach-carcinoma-intestinal_adenocarcinomaCOSMIC cancer mutationsstomach-carcinoma-intestinal_adenocarcinoma7225381682847 SLC4A10,CACNA1C,EDIL3,CAMK2B,SPTBN2,SLC8A3,NRG3,GRIN2B,CCDC136,GRM5,RYR2,SYT1,CACNA1E,L1CAM,NRXN3,CACNA2D1,RASGRF1,MCF2L2,PCLO,CACNA1A,RIMS1,CAMK2A,GABRB2,LRRC7,STX1A,DLGAP2,EPHA6,NRXN2,CACNA1G,PPFIA2,IQSEC2,FGF14,HCN1,SPTBN4,MYT1L,DNM1,SCN8A,PPFIA3
1.214e-07-15.92Effects of Botulinum toxinPathway Interaction DBbotulinumtoxinpathway94222614 STX1A,SYT1,SNAP25,RIMS1
1.281e-07-15.87learningbiological processGO:000761215471820447 DLG4,GRIN1,SLC8A3,GRM5,NRXN2,SNAP25,NRXN3
1.469e-07-15.73vocalization behaviorbiological processGO:00716251941820447 NRXN2,DLG4,BRINP1,NRXN3
1.482e-07-15.72GRB2 events in EGFR signalingREACTOME pathwaysR-HSA-17981224591028537 SPTBN2,CAMK2A,GRIN2B,CAMK2B,DLG4,NRG3,SPTBN4,RASGRF1,GRIN1
1.482e-07-15.72RAF/MAP kinase cascadeREACTOME pathwaysR-HSA-567300124591028537 SPTBN2,CAMK2A,GRIN2B,CAMK2B,DLG4,SPTBN4,NRG3,RASGRF1,GRIN1
1.482e-07-15.72SOS-mediated signallingREACTOME pathwaysR-HSA-11241224591028537 CAMK2B,DLG4,NRG3,SPTBN4,RASGRF1,GRIN1,SPTBN2,CAMK2A,GRIN2B
1.482e-07-15.72SHC1 events in EGFR signalingREACTOME pathwaysR-HSA-18033624591028537 GRIN2B,CAMK2A,SPTBN2,RASGRF1,GRIN1,NRG3,SPTBN4,DLG4,CAMK2B
1.583e-07-15.66central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtypeCOSMIC cancer mutationscentral_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype653121682847 EPHA6,CACNA1C,ABLIM1,GRM5,FGF14,PPFIA2,NRG3,MYT1L,RYR2,SCN8A,PCLO,NRXN3
1.609e-07-15.64SHH_subtypeCOSMIC cancer mutationsSHH_subtype654121682847 PCLO,SCN8A,NRXN3,MYT1L,RYR2,ABLIM1,GRM5,NRG3,FGF14,PPFIA2,EPHA6,CACNA1C
1.653e-07-15.62nervous system processbiological processGO:00508771376161820447 GRIN1,SLC4A10,HCN1,ABLIM1,GRM5,NRXN3,SLC8A3,DLG4,BRINP1,NRXN2,SPTBN4,SNAP25,RIMS1,RASGRF1,SCN8A,GRIN2B
1.661e-07-15.61neuron developmentbiological processGO:0048666859131820447 SNAP25,RASGRF1,BRINP1,DLG4,MYT1L,SPTBN4,NRXN3,SLC4A10,HCN1,GABRB2,CAMK2A,L1CAM,EPHA6
1.702e-07-15.59Signalling to p38 via RIT and RINREACTOME pathwaysR-HSA-18770624991028537 DLG4,CAMK2B,RASGRF1,GRIN1,NRG3,SPTBN4,SPTBN2,GRIN2B,CAMK2A
1.702e-07-15.59ARMS-mediated activationREACTOME pathwaysR-HSA-17098424991028537 DLG4,CAMK2B,GRIN1,RASGRF1,SPTBN4,NRG3,SPTBN2,GRIN2B,CAMK2A
1.761e-07-15.55Frs2-mediated activationREACTOME pathwaysR-HSA-17096825091028537 CAMK2A,GRIN2B,SPTBN2,NRG3,SPTBN4,GRIN1,RASGRF1,CAMK2B,DLG4
1.822e-07-15.52MAPK1/MAPK3 signalingREACTOME pathwaysR-HSA-568499625191028537 GRIN1,RASGRF1,SPTBN4,NRG3,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
1.859e-07-15.50voltage-gated calcium channel activity involved in cardiac muscle cell action potentialmolecular functionGO:0086007531809449 CACNA2D1,CACNA1G,CACNA1C
1.859e-07-15.50neuroligin family protein bindingmolecular functionGO:0097109531809449 DLG4,NRXN2,NRXN3
1.885e-07-15.48Prolonged ERK activation eventsREACTOME pathwaysR-HSA-16989325291028537 DLG4,CAMK2B,GRIN1,RASGRF1,NRG3,SPTBN4,SPTBN2,GRIN2B,CAMK2A
1.949e-07-15.45Signaling by LeptinREACTOME pathwaysR-HSA-258655225391028537 DLG4,CAMK2B,RASGRF1,GRIN1,SPTBN4,NRG3,SPTBN2,GRIN2B,CAMK2A
1.981e-07-15.43cardiac muscle cell contractionbiological processGO:00860035151820447 CACNA2D1,RYR2,CACNA1G,CACNA1C,SCN8A
1.990e-07-15.43regulation of neurotransmitter transportbiological processGO:00515889961820447 RIMS1,SYT1,PPFIA2,CPLX1,CAMK2A,STX1A
2.085e-07-15.38Interleukin receptor SHC signalingREACTOME pathwaysR-HSA-91252625591028537 SPTBN2,GRIN2B,CAMK2A,DLG4,CAMK2B,RASGRF1,GRIN1,NRG3,SPTBN4
2.155e-07-15.35Signalling to RASREACTOME pathwaysR-HSA-16704425691028537 SPTBN2,CAMK2A,GRIN2B,CAMK2B,DLG4,NRG3,SPTBN4,RASGRF1,GRIN1
2.156e-07-15.35cell communicationbiological processGO:00071545010301820447 GABRB2,HCN1,STX1A,GRIN1,CACNA1A,EPHA6,CAMK2A,GRM5,SLC8A3,SPTBN4,PPFIA3,SNAP25,GRIN2B,RYR2,CACNA1G,CACNA1E,CAMK2B,PCLO,DLG4,CACNA2D1,FGF14,NRXN2,CPLX1,DLGAP2,RASGRF1,NRG3,SYT1,RIMS1,CACNA1C,SCN8A
2.285e-07-15.29regulation of localizationbiological processGO:00328792028191820447 CPLX1,SPTBN4,FGF14,CACNA2D1,DLG4,GRIN2B,CACNA1C,SNAP25,RIMS1,SYT1,CAMK2A,VSNL1,PPFIA2,IQSEC2,STX1A,GRIN1,PCLO,CAMK2B,RYR2
2.303e-07-15.28VEGFR2 mediated cell proliferationREACTOME pathwaysR-HSA-521892125891028537 CAMK2A,GRIN2B,SPTBN2,SPTBN4,NRG3,RASGRF1,GRIN1,CAMK2B,DLG4
2.542e-07-15.19developmental processbiological processGO:00325025716321820447 SNAP25,GRIN2B,CELF3,SLC8A3,MYT1L,SPTBN4,LRRC7,NRXN3,SPTBN2,GRIN1,GABRB2,HCN1,CAMK2A,ABLIM1,EPHA6,L1CAM,RIMS1,CACNA1C,NRG3,SYT1,RASGRF1,SCN8A,BRINP1,DLG4,NRXN2,FGF14,CACNA1G,RYR2,CCDC136,PCLO,CAMK2B,SLC4A10
2.615e-07-15.16regulation of exocytosisbiological processGO:001715717171820447 PPFIA2,CPLX1,VSNL1,STX1A,PCLO,RIMS1,SYT1
2.624e-07-15.15Interleukin-2 signalingREACTOME pathwaysR-HSA-45192726291028537 SPTBN2,CAMK2A,GRIN2B,CAMK2B,DLG4,SPTBN4,NRG3,GRIN1,RASGRF1
2.659e-07-15.14Long-term potentiationKEGG pathwaysko04720676716130 GRIN2B,CAMK2B,CACNA1C,GRIN1,GRM5,CAMK2A
2.659e-07-15.14Long-term potentiationKEGG pathwayshsa04720676716130 CAMK2B,GRIN2B,GRM5,GRIN1,CAMK2A,CACNA1C
2.669e-07-15.14inorganic cation import across plasma membranebiological processGO:009865910461820447 SLC8A3,CACNA2D1,CACNA1G,CACNA1C,CACNA1E,CACNA1A
2.669e-07-15.14inorganic ion import across plasma membranebiological processGO:009958710461820447 CACNA1G,CACNA1C,CACNA2D1,SLC8A3,CACNA1A,CACNA1E
2.710e-07-15.12Signalling to ERKsREACTOME pathwaysR-HSA-18768726391028537 CAMK2B,DLG4,SPTBN4,NRG3,GRIN1,RASGRF1,SPTBN2,CAMK2A,GRIN2B
2.890e-07-15.06FCERI mediated MAPK activationREACTOME pathwaysR-HSA-287179626591028537 GRIN1,RASGRF1,SPTBN4,NRG3,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
2.908e-07-15.05Amphetamine addictionKEGG pathwayshsa05031686716130 STX1A,CACNA1C,GRIN2B,CAMK2B,CAMK2A,GRIN1
2.908e-07-15.05Amphetamine addictionKEGG pathwaysko05031686716130 CAMK2A,CACNA1C,STX1A,CAMK2B,GRIN2B,GRIN1
2.927e-07-15.04haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemiaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia3828271682847 FGF14,CACNA1G,PPFIA2,DLGAP2,LRRC7,SCN8A,HCN1,SNAP25,CCDC136,NRG3,SLC8A3,GRIN2B,SPTBN2,EDIL3,SLC4A10,CACNA1C,CAMK2B,PCLO,MCF2L2,GRIN1,RIMS1,CACNA2D1,NRXN3,L1CAM,RYR2,CACNA1E,SYT1
2.927e-07-15.04acute_lymphoblastic_B_cell_leukaemiaCOSMIC cancer mutationsacute_lymphoblastic_B_cell_leukaemia3828271682847 GRIN2B,SLC8A3,NRG3,CCDC136,CAMK2B,EDIL3,CACNA1C,SLC4A10,SPTBN2,CACNA2D1,NRXN3,RIMS1,GRIN1,MCF2L2,PCLO,SYT1,CACNA1E,RYR2,L1CAM,PPFIA2,CACNA1G,FGF14,LRRC7,DLGAP2,SCN8A,SNAP25,HCN1
3.190e-07-14.96cardiac muscle cell action potentialbiological processGO:00860015651820447 SCN8A,CACNA1C,CACNA1G,RYR2,CACNA2D1
3.246e-07-14.94thyroid-carcinomaCOSMIC cancer mutationsthyroid-carcinoma4126281682847 CACNA1C,SPTBN2,SLC8A3,GRIN2B,CCDC136,RYR2,SYT1,CACNA1E,L1CAM,NRXN3,MCF2L2,PCLO,RIMS1,CACNA1A,CAMK2A,CELF5,LRRC7,DLGAP2,EPHA6,NRXN2,CACNA1G,IQSEC2,HCN1,CAMKV,SPTBN4,MYT1L,DNM1,PPFIA3
3.386e-07-14.90RET signalingREACTOME pathwaysR-HSA-885365927091028537 DLG4,CAMK2B,GRIN1,RASGRF1,SPTBN4,NRG3,SPTBN2,GRIN2B,CAMK2A
3.433e-07-14.88localizationbiological processGO:00511794474281820447 SPTBN4,SLC8A3,GRIN2B,PPFIA3,SNAP25,CACNA1A,CAMK2A,HCN1,GABRB2,GRIN1,STX1A,SPTBN2,LRRC7,NRXN2,CPLX1,DLG4,CACNA2D1,SCN8A,DNM1,RIMS1,CACNA1C,SYT1,PPFIA2,SLC4A10,CACNA1E,PCLO,CACNA1G,RYR2
3.493e-07-14.87Interleukin-3, 5 and GM-CSF signalingREACTOME pathwaysR-HSA-51298827191028537 SPTBN2,GRIN2B,CAMK2A,DLG4,CAMK2B,GRIN1,RASGRF1,NRG3,SPTBN4
3.777e-07-14.79SNAP25 (synaptosome associated protein 25)protein interactions66165851945450 RIMS1,STX1A,DNM1,SYT1,CPLX1
4.157e-07-14.69protein localization to synapsebiological processGO:00354185951820447 DLG4,SNAP25,LRRC7,NRXN2,PCLO
4.439e-07-14.63lung-middle_lobe-carcinoma-adenocarcinomaCOSMIC cancer mutationslung-middle_lobe-carcinoma-adenocarcinoma1368161682847 L1CAM,MYT1L,HCN1,RYR2,CACNA1E,SPTBN4,GRIN1,NRXN3,CACNA2D1,EPHA6,CAMK2B,LRRC7,CCDC136,GRM5,SLC8A3,PPFIA2
4.920e-07-14.52Muscle contractionREACTOME pathwaysR-HSA-39701420481028537 FGF14,CAMK2B,CACNA1C,SCN8A,CACNA2D1,RYR2,CAMK2A,SLC8A3
5.095e-07-14.49middle_lobeCOSMIC cancer mutationsmiddle_lobe1382161682847 RYR2,HCN1,SPTBN4,CACNA1E,L1CAM,MYT1L,CACNA2D1,NRXN3,GRIN1,CAMK2B,LRRC7,EPHA6,SLC8A3,PPFIA2,CCDC136,GRM5
5.999e-07-14.33Ca_chan_IQpfam domainsPF08763731779547 CACNA1E,CACNA1C,CACNA1A
5.999e-07-14.33GPHHpfam domainsPF16905731779547 CACNA1A,CACNA1C,CACNA1E
6.046e-07-14.32VDCC_a1su_IQinterpro domainsIPR014873731852149 CACNA1A,CACNA1E,CACNA1C
6.046e-07-14.32GPHH_dominterpro domainsIPR031649731852149 CACNA1A,CACNA1E,CACNA1C
6.185e-07-14.30MAPK family signaling cascadesREACTOME pathwaysR-HSA-568305729091028537 CAMK2A,GRIN2B,SPTBN2,SPTBN4,NRG3,RASGRF1,GRIN1,CAMK2B,DLG4
6.552e-07-14.24cell-cell signaling involved in cardiac conductionbiological processGO:00860192741820447 CACNA1C,CACNA1G,CACNA2D1,RYR2
6.704e-07-14.22HAX1 (HCLS1 associated protein X-1)protein interactions1045639791945450 CAMK2B,VSNL1,DNM1,L1CAM,EDIL3,SYT1,CAMK2A,CAMKV,STX1A
6.939e-07-14.18IRS-mediated signallingREACTOME pathwaysR-HSA-11239929491028537 DLG4,CAMK2B,GRIN1,RASGRF1,NRG3,SPTBN4,SPTBN2,GRIN2B,CAMK2A
7.102e-07-14.16NGF signalling via TRKA from the plasma membraneREACTOME pathwaysR-HSA-187037387101028537 GRIN1,RASGRF1,DNM1,SPTBN4,NRG3,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
7.249e-07-14.14Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOME pathwaysR-HSA-11231414671028537 GRIN1,RASGRF1,GRIN2B,CAMK2A,GABRB2,DLG4,CAMK2B
7.332e-07-14.13excitatory synapsecellular componentGO:00600766551910850 SPTBN2,SCN8A,SYT1,GRIN1,DLG4
7.553e-07-14.10ERC2 (ELKS/RAB6-interacting/CAST family member 2)protein interactions260592841945450 RIMS1,PCLO,PPFIA3,PPFIA2
7.556e-07-14.10Insulin receptor signalling cascadeREACTOME pathwaysR-HSA-7475129791028537 SPTBN2,GRIN2B,CAMK2A,DLG4,CAMK2B,RASGRF1,GRIN1,SPTBN4,NRG3
7.557e-07-14.10action potentialbiological processGO:000150812461820447 HCN1,CACNA2D1,SCN8A,RYR2,CACNA1C,CACNA1G
7.772e-07-14.07IRS-related events triggered by IGF1RREACTOME pathwaysR-HSA-242892829891028537 GRIN1,RASGRF1,NRG3,SPTBN4,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
7.772e-07-14.07IGF1R signaling cascadeREACTOME pathwaysR-HSA-242892429891028537 CAMK2A,GRIN2B,SPTBN2,SPTBN4,NRG3,RASGRF1,GRIN1,CAMK2B,DLG4
7.823e-07-14.06ARMC1 (armadillo repeat containing 1)protein interactions551566751945450 CAMK2B,SYT1,CAMKV,VSNL1,CAMK2A
7.993e-07-14.04Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOME pathwaysR-HSA-240419229991028537 SPTBN2,GRIN2B,CAMK2A,DLG4,CAMK2B,GRIN1,RASGRF1,SPTBN4,NRG3
8.722e-07-13.95postsynaptic specialization membranecellular componentGO:009963412561910850 DLG4,GRIN2B,CACNA1C,GABRB2,GRM5,SCN8A
9.087e-07-13.91cerebellumCOSMIC cancer mutationscerebellum769121682847 PPFIA2,FGF14,NRG3,GRM5,ABLIM1,CACNA1C,EPHA6,NRXN3,SCN8A,PCLO,RYR2,MYT1L
9.165e-07-13.90mouthCOSMIC cancer mutationsmouth9004411682847 EPHA6,CELF5,CAMK2A,DLGAP2,LRRC7,GABRB2,ABLIM1,NRXN2,IQSEC2,PPFIA2,CACNA1G,MYT1L,HCN1,SNAP25,SPTBN4,SCN8A,PPFIA3,DNM1,CELF3,SPTBN2,SLC4A10,CACNA1C,EDIL3,CCDC136,GRM5,NRG3,SLC8A3,GRIN2B,L1CAM,RYR2,CACNA1E,SYT1,PCLO,DLG4,RASGRF1,MCF2L2,GRIN1,CACNA1A,RIMS1,NRXN3,CACNA2D1
9.839e-07-13.83cardiac conductionbiological processGO:00613377051820447 SPTBN4,RYR2,CACNA2D1,CACNA1C,CACNA1G
1.002e-06-13.81neuron projection terminuscellular componentGO:004430612861910850 SLC8A3,GRIN1,SLC4A10,DLG4,SYT1,CPLX1
1.180e-06-13.65regulation of cell communicationbiological processGO:00106463541241820447 SLC4A10,PPFIA2,RYR2,CAMK2B,DLG4,CAMKV,CPLX1,DLGAP2,RASGRF1,SYT1,NRG3,RIMS1,DNM1,STX1A,GRIN1,IQSEC2,CACNA1A,CAMK2A,GRM5,VSNL1,SLC8A3,PPFIA3,SNAP25,GRIN2B
1.188e-06-13.64-gene3d domains6.10.250.2180731447048 CACNA1C,CACNA1A,CACNA1E
1.188e-06-13.64-gene3d domains6.10.250.2500731447048 CACNA1E,CACNA1A,CACNA1C
1.280e-06-13.57central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cellCOSMIC cancer mutationscentral_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell1117141682847 EDIL3,DLGAP2,LRRC7,NRG3,FGF14,PPFIA2,L1CAM,RYR2,HCN1,CACNA1E,PPFIA3,PCLO,CACNA2D1,NRXN3
1.327e-06-13.53CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1)protein interactions55450931945450 GRIN2B,CAMK2B,CAMK2A
1.403e-06-13.48L1CAM interactionsREACTOME pathwaysR-HSA-37376010161028537 SPTBN2,SCN8A,L1CAM,SPTBN4,DNM1,DLG4
1.413e-06-13.47presynaptic active zone membranecellular componentGO:00487873241910850 STX1A,HCN1,SNAP25,SCN8A
1.483e-06-13.42Signaling by Insulin receptorREACTOME pathwaysR-HSA-7475232291028537 GRIN2B,CAMK2A,SPTBN2,GRIN1,RASGRF1,SPTBN4,NRG3,DLG4,CAMK2B
1.485e-06-13.42actin-mediated cell contractionbiological processGO:00702527651820447 SCN8A,CACNA2D1,RYR2,CACNA1C,CACNA1G
1.585e-06-13.36regulation of synaptic transmission, glutamatergicbiological processGO:00519667751820447 SYT1,GRIN1,GRM5,IQSEC2,GRIN2B
1.633e-06-13.32diffuse_large_B_cell_lymphomaCOSMIC cancer mutationsdiffuse_large_B_cell_lymphoma4151271682847 NRXN2,PPFIA2,FGF14,CAMK2A,CELF5,LRRC7,DLGAP2,SCN8A,HCN1,SPTBN4,GRM5,VSNL1,SLC8A3,NRG3,GRIN2B,SPTBN2,EDIL3,CACNA1C,CAMK2B,RASGRF1,PCLO,RIMS1,NRXN3,CACNA2D1,RYR2,SYT1,CACNA1E
1.654e-06-13.31right_lower_lobeCOSMIC cancer mutationsright_lower_lobe5692321682847 CAMK2B,CACNA1C,EDIL3,SLC4A10,SPTBN2,GRIN2B,NRG3,SLC8A3,GRM5,CCDC136,CACNA1E,RYR2,L1CAM,CACNA2D1,NRXN3,RIMS1,CACNA1A,PCLO,RASGRF1,MCF2L2,GRIN1,LRRC7,GABRB2,IQSEC2,PPFIA2,CACNA1G,NRXN2,CAMKV,HCN1,MYT1L,DNM1,SCN8A
1.654e-06-13.31lung-right_lower_lobe-carcinoma-adenocarcinomaCOSMIC cancer mutationslung-right_lower_lobe-carcinoma-adenocarcinoma5692321682847 NRXN3,CACNA2D1,CACNA1A,RIMS1,GRIN1,RASGRF1,MCF2L2,PCLO,CACNA1E,RYR2,L1CAM,GRIN2B,SLC8A3,NRG3,GRM5,CCDC136,CAMK2B,CACNA1C,SLC4A10,EDIL3,SPTBN2,DNM1,SCN8A,HCN1,CAMKV,MYT1L,PPFIA2,CACNA1G,IQSEC2,NRXN2,GABRB2,LRRC7
1.742e-06-13.26haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma3608251682847 HCN1,SCN8A,DLGAP2,LRRC7,CELF5,CAMK2A,FGF14,PPFIA2,NRXN2,SYT1,RYR2,NRXN3,CACNA2D1,RIMS1,PCLO,RASGRF1,CAMK2B,EDIL3,CACNA1C,SPTBN2,GRIN2B,NRG3,SLC8A3,VSNL1,GRM5
1.818e-06-13.22VEGFA-VEGFR2 PathwayREACTOME pathwaysR-HSA-442009733091028537 DLG4,CAMK2B,RASGRF1,GRIN1,NRG3,SPTBN4,SPTBN2,GRIN2B,CAMK2A
1.868e-06-13.19haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_relatedCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related1523161682847 RIMS1,NRXN3,CACNA2D1,CACNA1E,SYT1,RYR2,HCN1,VSNL1,CCDC136,FGF14,GRIN2B,CACNA1G,PPFIA2,NRG3,CELF3,EDIL3
1.868e-06-13.19acute_myeloid_leukaemia_therapy_relatedCOSMIC cancer mutationsacute_myeloid_leukaemia_therapy_related1523161682847 NRXN3,CACNA2D1,RIMS1,SYT1,CACNA1E,HCN1,RYR2,CACNA1G,PPFIA2,FGF14,GRIN2B,NRG3,VSNL1,CCDC136,EDIL3,CELF3
1.893e-06-13.18GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)protein interactions1164431031945450 DLG4,GRIN1,GRIN2B
2.163e-06-13.04Signaling by SCF-KITREACTOME pathwaysR-HSA-143355733791028537 SPTBN2,CAMK2A,GRIN2B,CAMK2B,DLG4,NRG3,SPTBN4,RASGRF1,GRIN1
2.189e-06-13.03Calcium Regulation in the Cardiac CellWikiPathwaysWP5361517531023 RYR2,CACNA1A,CACNA1C,CAMK2A,CAMK2B,SLC8A3,CACNA1E
2.192e-06-13.03transmembrane transportbiological processGO:00550851264141820447 CACNA1A,GABRB2,HCN1,SLC4A10,GRIN1,CACNA1E,CACNA1G,RYR2,CACNA2D1,SLC8A3,GRIN2B,SCN8A,SNAP25,CACNA1C
2.217e-06-13.02Signaling by VEGFREACTOME pathwaysR-HSA-19413833891028537 RASGRF1,GRIN1,SPTBN4,NRG3,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
2.236e-06-13.01Ca_chan_IQsmart domainsSM0106273971740 CACNA1A,CACNA1C,CACNA1E
2.250e-06-13.00neuron differentiationbiological processGO:00301821081131820447 SPTBN4,BRINP1,DLG4,MYT1L,RASGRF1,SNAP25,L1CAM,EPHA6,CAMK2A,SLC4A10,GABRB2,HCN1,NRXN3
2.280e-06-12.99SYT1 (synaptotagmin 1)protein interactions68578351945450 SYT1,SNAP25,RIMS1,STX1A,CACNA1A
2.283e-06-12.99ACTN2 (actinin alpha 2)protein interactions8815061945450 CACNA1C,CAMK2A,GRIN1,GRIN2B,LRRC7,DLG4
2.302e-06-12.98cardiac muscle contractionbiological processGO:00600488351820447 SCN8A,RYR2,CACNA2D1,CACNA1C,CACNA1G
2.314e-06-12.98anatomical structure developmentbiological processGO:00488565207291820447 SLC8A3,MYT1L,SPTBN4,SNAP25,GRIN2B,GRIN1,GABRB2,HCN1,ABLIM1,CAMK2A,EPHA6,L1CAM,NRXN3,LRRC7,SPTBN2,BRINP1,DLG4,NRXN2,FGF14,CACNA1C,NRG3,RASGRF1,SCN8A,SLC4A10,CACNA1G,RYR2,CCDC136,PCLO,CAMK2B
2.426e-06-12.93Gastrin-CREB signalling pathway via PKC and MAPKREACTOME pathwaysR-HSA-881907443101028537 GRM5,RASGRF1,GRIN1,NRG3,SPTBN4,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
2.509e-06-12.90regulation of monoatomic ion transportbiological processGO:004326946691820447 CAMK2B,GRIN2B,RYR2,CACNA1C,CAMK2A,FGF14,SPTBN4,CACNA2D1,GRIN1
2.598e-06-12.86Caskin1 (CASK interacting protein 1)protein interactions1407221131945450 SYT1,NRXN2,L1CAM
2.617e-06-12.85exocytosisbiological processGO:000688724171820447 STX1A,CPLX1,PPFIA3,RIMS1,SNAP25,SYT1,PCLO
2.745e-06-12.81protein localization to cell junctionbiological processGO:19024148651820447 DLG4,LRRC7,SNAP25,PCLO,NRXN2
3.042e-06-12.70thyroid-other-neoplasmCOSMIC cancer mutationsthyroid-other-neoplasm7637371682847 L1CAM,CACNA1E,SYT1,RYR2,CACNA1A,RIMS1,PCLO,DLG4,GRIN1,RASGRF1,CACNA2D1,NRXN3,SPTBN2,CELF3,CAMK2B,EDIL3,CACNA1C,GRM5,CCDC136,GRIN2B,NRG3,MYT1L,SPTBN4,CAMKV,SCN8A,PPFIA3,DNM1,EPHA6,DLGAP2,STX1A,LRRC7,CELF5,CAMK2A,ABLIM1,IQSEC2,CACNA1G,NRXN2
3.097e-06-12.69Downstream signal transductionREACTOME pathwaysR-HSA-18676335291028537 GRIN1,RASGRF1,NRG3,SPTBN4,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
3.398e-06-12.59DAP12 signalingREACTOME pathwaysR-HSA-242449135691028537 CAMK2B,DLG4,NRG3,SPTBN4,GRIN1,RASGRF1,SPTBN2,CAMK2A,GRIN2B
3.526e-06-12.56adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioningCOSMIC cancer mutationsadrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning1803171682847 EPHA6,SPTBN2,SLC4A10,CCDC136,GRM5,NRG3,NRXN2,L1CAM,MYT1L,RYR2,HCN1,PCLO,SCN8A,GRIN1,CACNA1A,RIMS1,NRXN3
3.526e-06-12.56functioningCOSMIC cancer mutationsfunctioning1803171682847 NRG3,NRXN2,CCDC136,GRM5,SLC4A10,EPHA6,SPTBN2,NRXN3,SCN8A,PCLO,GRIN1,CACNA1A,RIMS1,RYR2,HCN1,L1CAM,MYT1L
3.633e-06-12.53Interaction between L1 and AnkyrinsREACTOME pathwaysR-HSA-4450953041028537 SPTBN2,SCN8A,SPTBN4,L1CAM
3.725e-06-12.50positive regulation of cytosolic calcium ion concentrationbiological processGO:000720416361820447 CACNA1C,RYR2,DLG4,GRIN1,CACNA2D1,CACNA1A
3.997e-06-12.43import across plasma membranebiological processGO:009873916561820447 CACNA1E,CACNA1C,CACNA1G,CACNA1A,SLC8A3,CACNA2D1
4.023e-06-12.42upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsupper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma6953351682847 L1CAM,CACNA1E,RYR2,RIMS1,MCF2L2,RASGRF1,DLG4,GRIN1,PCLO,CACNA2D1,NRXN3,SPTBN2,CACNA1C,SLC4A10,GRM5,CCDC136,GRIN2B,SLC8A3,NRG3,MYT1L,SPTBN4,SNAP25,HCN1,PPFIA3,SCN8A,DNM1,EPHA6,GABRB2,LRRC7,DLGAP2,ABLIM1,CACNA1G,PPFIA2,IQSEC2,NRXN2
4.077e-06-12.41Signaling by EGFRREACTOME pathwaysR-HSA-17792936491028537 GRIN2B,CAMK2A,SPTBN2,RASGRF1,GRIN1,NRG3,SPTBN4,DLG4,CAMK2B
4.128e-06-12.40neurogenesisbiological processGO:00220081334141820447 SLC4A10,HCN1,GABRB2,CAMK2A,EPHA6,L1CAM,NRXN3,SLC8A3,DLG4,BRINP1,MYT1L,SPTBN4,SNAP25,RASGRF1
4.530e-06-12.30calcium ion transport into cytosolbiological processGO:00604021331820447 CACNA2D1,RYR2,CACNA1C
4.562e-06-12.30lung-carcinoma-small_cell_carcinomaCOSMIC cancer mutationslung-carcinoma-small_cell_carcinoma9908421682847 LRRC7,DLGAP2,CAMK2A,CELF5,EPHA6,CACNA1G,PPFIA2,FGF14,IQSEC2,NRXN2,ABLIM1,SNAP25,SPTBN4,CAMKV,HCN1,MYT1L,DNM1,SCN8A,PPFIA3,CAMK2B,CPLX1,SLC4A10,EDIL3,CACNA1C,SPTBN2,CELF3,GRIN2B,SLC8A3,NRG3,GRM5,VSNL1,SYT1,CACNA1E,RYR2,L1CAM,NRXN3,CACNA2D1,RIMS1,DLG4,MCF2L2,RASGRF1,PCLO
4.644e-06-12.28small_cell_carcinomaCOSMIC cancer mutationssmall_cell_carcinoma9913421682847 GRIN2B,NRG3,SLC8A3,VSNL1,GRM5,CPLX1,CAMK2B,EDIL3,SLC4A10,CACNA1C,SPTBN2,CELF3,CACNA2D1,NRXN3,RIMS1,PCLO,RASGRF1,DLG4,MCF2L2,CACNA1E,SYT1,RYR2,L1CAM,IQSEC2,FGF14,PPFIA2,CACNA1G,NRXN2,ABLIM1,DLGAP2,LRRC7,CELF5,CAMK2A,EPHA6,DNM1,PPFIA3,SCN8A,SNAP25,SPTBN4,CAMKV,HCN1,MYT1L
4.709e-06-12.27Signalling by NGFREACTOME pathwaysR-HSA-166520477101028537 NRG3,SPTBN4,GRIN1,RASGRF1,DNM1,CAMK2B,DLG4,CAMK2A,GRIN2B,SPTBN2
4.764e-06-12.25DAP12 interactionsREACTOME pathwaysR-HSA-217212737191028537 NRG3,SPTBN4,GRIN1,RASGRF1,CAMK2B,DLG4,CAMK2A,GRIN2B,SPTBN2
4.808e-06-12.25generation of neuronsbiological processGO:00486991158131820447 NRXN3,CAMK2A,EPHA6,L1CAM,SLC4A10,GABRB2,HCN1,SNAP25,RASGRF1,SPTBN4,BRINP1,DLG4,MYT1L
4.857e-06-12.24regulation of signalingbiological processGO:00230513534231820447 SLC8A3,GRIN2B,PPFIA3,SNAP25,CACNA1A,IQSEC2,CAMK2A,GRM5,VSNL1,STX1A,GRIN1,DLGAP2,CPLX1,DLG4,CAMKV,DNM1,RASGRF1,RIMS1,SYT1,NRG3,PPFIA2,SLC4A10,CAMK2B
4.858e-06-12.23UNC13B (unc-13 homolog B)protein interactions104974441945450 SNAP25,RIMS1,STX1A,SPTBN2
4.870e-06-12.23Fc epsilon receptor (FCERI) signalingREACTOME pathwaysR-HSA-245420237291028537 DLG4,CAMK2B,RASGRF1,GRIN1,SPTBN4,NRG3,SPTBN2,GRIN2B,CAMK2A
5.031e-06-12.20diffuse_adenocarcinomaCOSMIC cancer mutationsdiffuse_adenocarcinoma4383271682847 CAMK2A,DLGAP2,LRRC7,EPHA6,NRXN2,FGF14,PPFIA2,CACNA1G,ABLIM1,CAMKV,HCN1,SPTBN4,MYT1L,PPFIA3,CACNA1C,CAMK2B,NRG3,GRM5,RYR2,CACNA1E,NRXN3,CACNA2D1,PCLO,RASGRF1,MCF2L2,CACNA1A,RIMS1
5.031e-06-12.20stomach-carcinoma-diffuse_adenocarcinomaCOSMIC cancer mutationsstomach-carcinoma-diffuse_adenocarcinoma4383271682847 PPFIA3,SPTBN4,HCN1,CAMKV,MYT1L,PPFIA2,CACNA1G,FGF14,NRXN2,ABLIM1,LRRC7,DLGAP2,CAMK2A,EPHA6,CACNA2D1,NRXN3,RIMS1,CACNA1A,MCF2L2,RASGRF1,PCLO,CACNA1E,RYR2,NRG3,GRM5,CAMK2B,CACNA1C
5.055e-06-12.20Neurotoxicity of clostridium toxinsREACTOME pathwaysR-HSA-1687991031028537 STX1A,SNAP25,SYT1
5.314e-06-12.15Signaling by PDGFREACTOME pathwaysR-HSA-18679737691028537 SPTBN2,GRIN2B,CAMK2A,DLG4,CAMK2B,RASGRF1,GRIN1,NRG3,SPTBN4
5.377e-06-12.13cell communication involved in cardiac conductionbiological processGO:00860654541820447 RYR2,CACNA2D1,CACNA1C,CACNA1G
5.499e-06-12.11heart contractionbiological processGO:00600479951820447 SCN8A,CACNA1G,CACNA1C,RYR2,CACNA2D1
5.579e-06-12.10dendritic spinecellular componentGO:004319717261910850 DLG4,CAMK2A,GRIN1,GRM5,PPFIA2,SLC8A3
5.962e-06-12.03neuron spinecellular componentGO:004430917461910850 SLC8A3,PPFIA2,GRM5,GRIN1,CAMK2A,DLG4
6.067e-06-12.01actin filament-based movementbiological processGO:003004810151820447 SCN8A,RYR2,CACNA2D1,CACNA1C,CACNA1G
6.202e-06-11.99Glutamatergic synapseKEGG pathwayshsa047241146716130 DLG4,CACNA1A,CACNA1C,GRM5,GRIN2B,GRIN1
6.202e-06-11.99Glutamatergic synapseKEGG pathwaysko047241146716130 GRIN1,GRM5,GRIN2B,CACNA1C,DLG4,CACNA1A
6.551e-06-11.94postsynaptic density membranecellular componentGO:009883910151910850 SCN8A,DLG4,GRIN2B,CACNA1C,GRM5
6.566e-06-11.93papillary_renal_cell_carcinomaCOSMIC cancer mutationspapillary_renal_cell_carcinoma6364331682847 EPHA6,CELF5,CAMK2A,DLGAP2,GABRB2,ABLIM1,NRXN2,IQSEC2,PPFIA2,CACNA1G,MYT1L,CAMKV,SPTBN4,SCN8A,DNM1,CELF3,SPTBN2,SLC4A10,CACNA1C,CAMK2B,GRM5,NRG3,SLC8A3,GRIN2B,RYR2,CACNA1E,PCLO,RASGRF1,MCF2L2,RIMS1,CACNA1A,CACNA2D1,NRXN3
6.566e-06-11.93kidney-carcinoma-papillary_renal_cell_carcinomaCOSMIC cancer mutationskidney-carcinoma-papillary_renal_cell_carcinoma6364331682847 RYR2,CACNA1E,NRXN3,CACNA2D1,PCLO,MCF2L2,RASGRF1,CACNA1A,RIMS1,CACNA1C,SLC4A10,CAMK2B,CELF3,SPTBN2,NRG3,SLC8A3,GRIN2B,GRM5,CAMKV,SPTBN4,MYT1L,DNM1,SCN8A,CELF5,CAMK2A,DLGAP2,GABRB2,EPHA6,NRXN2,IQSEC2,CACNA1G,PPFIA2,ABLIM1
6.615e-06-11.93regulation of metal ion transportbiological processGO:001095939381820447 CACNA1C,RYR2,CAMK2B,GRIN1,CACNA2D1,CAMK2A,FGF14,SPTBN4
6.649e-06-11.92distal axoncellular componentGO:015003427371910850 SLC4A10,SNAP25,RASGRF1,GRIN1,SLC8A3,CPLX1,L1CAM
6.679e-06-11.92regulation of heart ratebiological processGO:000202710351820447 CACNA2D1,RYR2,CACNA1G,CACNA1C,SPTBN4
6.982e-06-11.87calcium-ion regulated exocytosisbiological processGO:00171564841820447 SYT1,RIMS1,STX1A,SNAP25
7.169e-06-11.85Burkitt_lymphomaCOSMIC cancer mutationsBurkitt_lymphoma2119181682847 EDIL3,CAMK2A,DLGAP2,LRRC7,CCDC136,NRG3,NRXN2,FGF14,GRIN2B,PPFIA2,RYR2,HCN1,SPTBN4,SYT1,PCLO,RIMS1,CACNA2D1,NRXN3
7.169e-06-11.85haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma2119181682847 HCN1,RYR2,SYT1,SPTBN4,NRXN3,CACNA2D1,PCLO,RIMS1,CAMK2A,EDIL3,LRRC7,DLGAP2,NRG3,NRXN2,PPFIA2,FGF14,GRIN2B,CCDC136
7.221e-06-11.84multicellular organismal processbiological processGO:00325016177311820447 GRIN1,HCN1,GABRB2,ABLIM1,CAMK2A,GRM5,EPHA6,L1CAM,LRRC7,NRXN3,SPTBN2,SLC8A3,MYT1L,SPTBN4,SNAP25,GRIN2B,SLC4A10,CACNA1G,RYR2,PCLO,CAMK2B,CACNA2D1,DLG4,BRINP1,NRXN2,FGF14,RIMS1,CACNA1C,NRG3,RASGRF1,SCN8A
7.687e-06-11.78regulation of postsynaptic membrane potentialbiological processGO:006007810651820447 GABRB2,HCN1,GRIN1,GRIN2B,GRM5
8.021e-06-11.73import into cellbiological processGO:0098657687101820447 SYT1,CACNA1G,SNAP25,CACNA1C,DNM1,CACNA1E,CACNA2D1,SLC8A3,STX1A,CACNA1A
8.068e-06-11.73brainstemCOSMIC cancer mutationsbrainstem3102221682847 FGF14,PPFIA2,DLGAP2,LRRC7,GABRB2,HCN1,SPTBN4,SNAP25,CCDC136,NRG3,SPTBN2,SLC4A10,EDIL3,CPLX1,CAMK2B,MCF2L2,CACNA1A,RIMS1,CACNA2D1,NRXN3,RYR2,SYT1
9.001e-06-11.62Regulation of insulin secretionREACTOME pathwaysR-HSA-4223568051028537 CACNA1C,SNAP25,CACNA1A,STX1A,CACNA1E
9.512e-06-11.56cortical cytoskeletoncellular componentGO:003086310951910850 SPTBN4,SPTBN2,DLG4,PCLO,RIMS1
9.537e-06-11.56DLG3 (discs large MAGUK scaffold protein 3)protein interactions174111151945450 GRIN2B,GRIN1,DLGAP2,DLG4,CAMK2A
9.753e-06-11.54regulation of secretion by cellbiological processGO:190353055191820447 PCLO,SNAP25,RIMS1,SYT1,PPFIA2,CAMK2A,VSNL1,CPLX1,STX1A
1.020e-05-11.49SNARE bindingmolecular functionGO:000014910751809449 SYT1,CACNA1A,SNAP25,STX1A,CPLX1
1.041e-05-11.47biological process involved in intraspecies interaction between organismsbiological processGO:00517035341820447 DLG4,BRINP1,NRXN3,NRXN2
1.041e-05-11.47social behaviorbiological processGO:00351765341820447 NRXN3,BRINP1,DLG4,NRXN2
1.047e-05-11.47central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastomaCOSMIC cancer mutationscentral_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma7205351682847 HCN1,SPTBN4,SNAP25,ABLIM1,NRXN2,PPFIA2,CACNA1G,FGF14,IQSEC2,EPHA6,CAMK2A,CELF5,GABRB2,LRRC7,DLGAP2,MCF2L2,RASGRF1,GRIN1,PCLO,RIMS1,NRXN3,CACNA2D1,RYR2,SYT1,CACNA1E,GRM5,VSNL1,SLC8A3,NRG3,GRIN2B,SPTBN2,EDIL3,CACNA1C,CAMK2B,CPLX1
1.051e-05-11.46heart processbiological processGO:000301511351820447 SCN8A,CACNA1G,CACNA1C,CACNA2D1,RYR2
1.069e-05-11.45membrane depolarization during cardiac muscle cell action potentialbiological processGO:00860121731820447 CACNA2D1,CACNA1G,CACNA1C
1.074e-05-11.44secretion by cellbiological processGO:003294042081820447 CPLX1,NRXN2,STX1A,PCLO,SYT1,RIMS1,SNAP25,PPFIA3
1.100e-05-11.42Signaling by InterleukinsREACTOME pathwaysR-HSA-449147525101028537 RASGRF1,GRIN1,NRG3,SPTBN4,STX1A,DLG4,CAMK2B,GRIN2B,CAMK2A,SPTBN2
1.117e-05-11.40presynaptic active zone cytoplasmic componentcellular componentGO:00988311731910850 PPFIA3,RIMS1,PCLO
1.196e-05-11.33Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium ChannelsREACTOME pathwaysR-HSA-1123081331028537 CACNA1A,CACNA1E,CACNA2D1
1.281e-05-11.27calcium ion-regulated exocytosis of neurotransmitterbiological processGO:00487911831820447 SYT1,SNAP25,RIMS1
1.297e-05-11.25synapse assemblybiological processGO:000741611851820447 NRG3,GABRB2,PCLO,NRXN2,SPTBN2
1.298e-05-11.25vesicle dockingbiological processGO:00482785641820447 PPFIA3,STX1A,SNAP25,SYT1
1.309e-05-11.24cellular component organizationbiological processGO:00160435636291820447 SPTBN2,NRXN3,ABLIM1,CAMK2A,GRM5,EPHA6,L1CAM,IQSEC2,STX1A,GRIN1,GABRB2,HCN1,CELF5,GRIN2B,SNAP25,PPFIA3,SPTBN4,CELF3,SLC8A3,CCDC136,PCLO,PPFIA2,DNM1,RIMS1,SYT1,NRG3,RASGRF1,NRXN2,DLG4
1.407e-05-11.17striated muscle contractionbiological processGO:000694112051820447 CACNA1G,CACNA1C,CACNA2D1,RYR2,SCN8A
1.417e-05-11.16chondroblastomaCOSMIC cancer mutationschondroblastoma53491682847 FGF14,PPFIA2,NRXN3,NRG3,RIMS1,DLGAP2,SYT1,EDIL3,HCN1
1.504e-05-11.10NLGN1 (neuroligin 1)protein interactions228711931945450 NRXN3,NRXN2,DLG4
1.504e-05-11.10regulation of heart contractionbiological processGO:000801620861820447 CACNA1C,CACNA1G,RYR2,SPTBN4,CACNA2D1,SLC8A3
1.583e-05-11.05SYNGAP1 (synaptic Ras GTPase activating protein 1)protein interactions88315941945450 DLG4,GRIN1,GRIN2B,CAMK2A
1.616e-05-11.03cell cortexcellular componentGO:000593831371910850 SPTBN4,PPFIA3,PCLO,RIMS1,DLG4,SPTBN2,SNAP25
1.691e-05-10.99humerusCOSMIC cancer mutationshumerus54691682847 EDIL3,RYR2,HCN1,DLGAP2,NRXN3,FGF14,PPFIA2,PCLO,RIMS1
1.729e-05-10.97adrenal_cortical_carcinomaCOSMIC cancer mutationsadrenal_cortical_carcinoma2256181682847 NRG3,NRXN2,GRM5,CCDC136,SLC4A10,CACNA1C,SPTBN2,EPHA6,NRXN3,CACNA1A,RIMS1,GRIN1,SCN8A,PCLO,HCN1,RYR2,MYT1L,L1CAM
1.861e-05-10.89bone-humerus-other-chondroblastomaCOSMIC cancer mutationsbone-humerus-other-chondroblastoma30171682847 DLGAP2,HCN1,EDIL3,PPFIA2,FGF14,NRXN3,RIMS1
1.926e-05-10.86carcinoid-endocrine_tumourCOSMIC cancer mutationscarcinoid-endocrine_tumour7752361682847 CAMKV,HCN1,SNAP25,SPTBN4,SCN8A,PPFIA3,EPHA6,CELF5,CAMK2A,DLGAP2,GABRB2,STX1A,LRRC7,ABLIM1,NRXN2,FGF14,PPFIA2,RYR2,CACNA1E,SYT1,PCLO,GRIN1,MCF2L2,RIMS1,CACNA1A,NRXN3,CACNA2D1,SPTBN2,EDIL3,SLC4A10,CACNA1C,CAMK2B,VSNL1,NRG3,SLC8A3,GRIN2B
1.930e-05-10.86DLG2 (discs large MAGUK scaffold protein 2)protein interactions17406241945450 GRIN1,DLGAP2,GRIN2B,DLG4
1.954e-05-10.84calcium ion transmembrane transport via high voltage-gated calcium channelbiological processGO:0061577321820447 CACNA2D1,CACNA1C
2.038e-05-10.80thyroidCOSMIC cancer mutationsthyroid9867411682847 SLC8A3,NRG3,GRIN2B,CCDC136,GRM5,SLC4A10,EDIL3,CACNA1C,CAMK2B,CELF3,SPTBN2,NRXN3,CACNA2D1,MCF2L2,GRIN1,DLG4,RASGRF1,PCLO,CACNA1A,RIMS1,RYR2,SYT1,CACNA1E,L1CAM,NRXN2,CACNA1G,IQSEC2,ABLIM1,CAMK2A,CELF5,STX1A,LRRC7,DLGAP2,EPHA6,DNM1,SCN8A,PPFIA3,CAMKV,HCN1,SPTBN4,MYT1L
2.053e-05-10.79regulation of secretionbiological processGO:005104660591820447 SYT1,RIMS1,SNAP25,PCLO,STX1A,CPLX1,VSNL1,CAMK2A,PPFIA2
2.060e-05-10.79Nicotine addictionKEGG pathwayshsa05033404716130 GABRB2,GRIN2B,GRIN1,CACNA1A
2.060e-05-10.79Nicotine addictionKEGG pathwaysko05033404716130 CACNA1A,GRIN2B,GABRB2,GRIN1
2.070e-05-10.79syntaxin bindingmolecular functionGO:00199056041809449 CPLX1,CACNA1A,SYT1,SNAP25
2.072e-05-10.78cellular component assemblybiological processGO:00226072472181820447 SPTBN2,PCLO,CCDC136,ABLIM1,HCN1,GABRB2,GRIN1,GRIN2B,CELF5,DNM1,NRG3,SYT1,SNAP25,RIMS1,SPTBN4,NRXN2,DLG4,CELF3
2.093e-05-10.77trunkCOSMIC cancer mutationstrunk3554231682847 PPFIA2,IQSEC2,NRXN2,ABLIM1,CELF5,EPHA6,PPFIA3,SPTBN4,SNAP25,HCN1,MYT1L,GRIN2B,SLC8A3,NRG3,VSNL1,CACNA1C,EDIL3,SPTBN2,NRXN3,CACNA2D1,CACNA1E,RYR2,L1CAM
2.152e-05-10.75voltage-gated calcium channel activity involved in AV node cell action potentialmolecular functionGO:0086056321809449 CACNA1C,CACNA1G
2.166e-05-10.74central_nervous_system-brainstem-glioma-astrocytoma_Grade_IVCOSMIC cancer mutationscentral_nervous_system-brainstem-glioma-astrocytoma_Grade_IV2531191682847 RYR2,HCN1,SYT1,CACNA2D1,NRXN3,MCF2L2,RIMS1,CACNA1A,EDIL3,SLC4A10,DLGAP2,CPLX1,LRRC7,GABRB2,CAMK2B,NRG3,FGF14,PPFIA2,CCDC136
2.169e-05-10.74axon initial segmentcellular componentGO:00431942131910850 SPTBN4,SCN8A,LRRC7
2.174e-05-10.74prostate-carcinomaCOSMIC cancer mutationsprostate-carcinoma9000391682847 EDIL3,CACNA1C,SLC4A10,CAMK2B,CPLX1,CELF3,SPTBN2,SLC8A3,NRG3,GRIN2B,GRM5,VSNL1,RYR2,SYT1,CACNA1E,L1CAM,CACNA2D1,NRXN3,MCF2L2,RASGRF1,GRIN1,PCLO,RIMS1,CAMK2A,CELF5,LRRC7,GABRB2,DLGAP2,EPHA6,NRXN2,CACNA1G,PPFIA2,FGF14,IQSEC2,ABLIM1,HCN1,MYT1L,PPFIA3,SCN8A
2.293e-05-10.68right_upper_lobeCOSMIC cancer mutationsright_upper_lobe10376421682847 GRM5,VSNL1,CCDC136,GRIN2B,SLC8A3,NRG3,SPTBN2,CELF3,CAMK2B,EDIL3,CACNA1C,SLC4A10,CACNA1A,RIMS1,GRIN1,RASGRF1,DLG4,MCF2L2,PCLO,CACNA2D1,NRXN3,L1CAM,CACNA1E,RYR2,ABLIM1,PPFIA2,CACNA1G,IQSEC2,NRXN2,EPHA6,LRRC7,STX1A,GABRB2,DLGAP2,CELF5,PPFIA3,SCN8A,DNM1,MYT1L,SPTBN4,HCN1,CAMKV
2.293e-05-10.68lung-right_upper_lobe-carcinoma-adenocarcinomaCOSMIC cancer mutationslung-right_upper_lobe-carcinoma-adenocarcinoma10376421682847 DLGAP2,STX1A,LRRC7,GABRB2,CELF5,EPHA6,IQSEC2,CACNA1G,PPFIA2,NRXN2,ABLIM1,SPTBN4,HCN1,CAMKV,MYT1L,DNM1,SCN8A,PPFIA3,CAMK2B,CACNA1C,EDIL3,SLC4A10,SPTBN2,CELF3,GRIN2B,NRG3,SLC8A3,VSNL1,GRM5,CCDC136,CACNA1E,RYR2,L1CAM,CACNA2D1,NRXN3,CACNA1A,RIMS1,PCLO,RASGRF1,GRIN1,DLG4,MCF2L2
2.384e-05-10.64synaptic vesiclecellular componentGO:000802122261910850 GRIN1,SYT1,PPFIA2,DLG4,SNAP25,STX1A
2.400e-05-10.64membrane depolarization during action potentialbiological processGO:00860102231820447 CACNA2D1,CACNA1C,CACNA1G
2.473e-05-10.61endometrium-carcinoma-serous_carcinomaCOSMIC cancer mutationsendometrium-carcinoma-serous_carcinoma1442141682847 GRM5,SLC8A3,PPFIA2,EPHA6,CACNA1C,DLGAP2,LRRC7,PCLO,MCF2L2,RASGRF1,CACNA1A,RIMS1,MYT1L,RYR2
2.842e-05-10.47plasma_cell_myelomaCOSMIC cancer mutationsplasma_cell_myeloma1263131682847 GRIN2B,NRG3,ABLIM1,LRRC7,CAMK2A,CACNA1C,CACNA1A,PCLO,SCN8A,CACNA1E,HCN1,RYR2,L1CAM
2.842e-05-10.47haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myelomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma1263131682847 CACNA1E,RYR2,HCN1,L1CAM,CACNA1A,SCN8A,PCLO,LRRC7,CACNA1C,CAMK2A,GRIN2B,NRG3,ABLIM1
2.894e-05-10.45cellular component organization or biogenesisbiological processGO:00718405850291820447 DNM1,RIMS1,NRG3,SYT1,RASGRF1,NRXN2,DLG4,CCDC136,PCLO,PPFIA2,CELF5,GRIN2B,SNAP25,PPFIA3,SPTBN4,CELF3,SLC8A3,SPTBN2,NRXN3,GRM5,CAMK2A,ABLIM1,L1CAM,EPHA6,IQSEC2,STX1A,GRIN1,HCN1,GABRB2
2.986e-05-10.42main axoncellular componentGO:00443046841910850 LRRC7,DLG4,SCN8A,SPTBN4
3.022e-05-10.41export from cellbiological processGO:014035248581820447 NRXN2,CPLX1,STX1A,PCLO,SYT1,RIMS1,SNAP25,PPFIA3
3.115e-05-10.38CAMK2A (calcium/calmodulin dependent protein kinase II alpha)protein interactions81523761945450 LRRC7,CAMK2B,GRIN2B,GRIN1,RIMS1,CAMK2A
3.565e-05-10.24regulation of long-term neuronal synaptic plasticitybiological processGO:00481692531820447 DLG4,CAMK2B,GRM5
3.615e-05-10.23Type II diabetes mellitusKEGG pathwaysko04930464716130 CACNA1E,CACNA1A,CACNA1G,CACNA1C
3.615e-05-10.23Type II diabetes mellitusKEGG pathwayshsa04930464716130 CACNA1C,CACNA1E,CACNA1G,CACNA1A
3.671e-05-10.21lymph_nodeCOSMIC cancer mutationslymph_node1703151682847 MYT1L,SPTBN4,CACNA1E,RYR2,RIMS1,PCLO,RASGRF1,NRXN3,CACNA2D1,DLGAP2,LRRC7,CAMK2A,GRIN2B,PPFIA2,NRG3
3.742e-05-10.19biological regulationbiological processGO:006500712501441820447 RASGRF1,NRG3,SYT1,CACNA1C,RIMS1,DNM1,SCN8A,BRINP1,DLG4,CACNA2D1,CAMKV,FGF14,CPLX1,NRXN2,DLGAP2,RYR2,CACNA1G,CACNA1E,CAMK2B,PCLO,SLC4A10,PPFIA2,EDIL3,PPFIA3,SNAP25,GRIN2B,CELF5,MYT1L,SLC8A3,CELF3,SPTBN4,LRRC7,SPTBN2,HCN1,GABRB2,GRIN1,STX1A,IQSEC2,EPHA6,CACNA1A,L1CAM,GRM5,VSNL1,CAMK2A
3.769e-05-10.19Toxicity of botulinum toxin type C (BoNT/C)REACTOME pathwaysR-HSA-5250971321028537 STX1A,SNAP25
3.778e-05-10.18exocytic vesiclecellular componentGO:007038224161910850 PPFIA2,DLG4,SYT1,GRIN1,SNAP25,STX1A
3.869e-05-10.16regulation of synapse organizationbiological processGO:005080724661820447 CAMKV,PPFIA2,IQSEC2,SNAP25,GRIN2B,CAMK2B
3.872e-05-10.16Rad23a (RAD23 homolog A, nucleotide excision repair protein)protein interactions361381421945450 CAMK2A,CAMK2B
3.872e-05-10.16Grin2a (glutamate receptor, ionotropic, NMDA2A (epsilon 1))protein interactions14811421945450 GRIN2B,GRIN1
3.931e-05-10.14organelle localization by membrane tetheringbiological processGO:01400567441820447 SYT1,SNAP25,STX1A,PPFIA3
4.006e-05-10.13large_intestine-caecum-adenomaCOSMIC cancer mutationslarge_intestine-caecum-adenoma22961682847 PCLO,DLGAP2,CACNA1C,EDIL3,HCN1,MYT1L
4.083e-05-10.11CaMKII_ADpfam domainsPF08332421779547 CAMK2A,CAMK2B
4.100e-05-10.10CELF3/4/5/6_RRM1interpro domainsIPR034648421852149 CELF3,CELF5
4.100e-05-10.10Liprin-alpha_SAM_rpt_2interpro domainsIPR037621421852149 PPFIA3,PPFIA2
4.100e-05-10.10Liprin-alpha_SAM_rpt_1interpro domainsIPR037620421852149 PPFIA3,PPFIA2
4.100e-05-10.10Spectrin_bsuinterpro domainsIPR016343421852149 SPTBN2,SPTBN4
4.100e-05-10.10Ca/CaM-dep_prot_kinase-associnterpro domainsIPR013543421852149 CAMK2A,CAMK2B
4.100e-05-10.10Liprin-alpha_SAM_rpt_3interpro domainsIPR037622421852149 PPFIA3,PPFIA2
4.140e-05-10.09regulation of calcium ion transportbiological processGO:005192424961820447 CACNA1C,RYR2,CAMK2B,GRIN1,CACNA2D1,CAMK2A
4.425e-05-10.03regulation of synapse structure or activitybiological processGO:005080325261820447 CAMK2B,GRIN2B,SNAP25,IQSEC2,PPFIA2,CAMKV
4.427e-05-10.03Integration of energy metabolismREACTOME pathwaysR-HSA-16368511151028537 CACNA1E,STX1A,CACNA1A,SNAP25,CACNA1C
4.516e-05-10.01haematopoietic_neoplasmCOSMIC cancer mutationshaematopoietic_neoplasm11082431682847 CACNA1A,RIMS1,PCLO,DLG4,GRIN1,MCF2L2,RASGRF1,NRXN3,CACNA2D1,L1CAM,CACNA1E,SYT1,RYR2,VSNL1,GRM5,CCDC136,GRIN2B,NRG3,SPTBN2,CELF3,CPLX1,CAMK2B,EDIL3,CACNA1C,SLC4A10,PPFIA3,SCN8A,DNM1,MYT1L,SPTBN4,CAMKV,HCN1,ABLIM1,FGF14,IQSEC2,PPFIA2,CACNA1G,NRXN2,EPHA6,DLGAP2,LRRC7,CELF5,CAMK2A
4.555e-05-10.00Ion homeostasisREACTOME pathwaysR-HSA-55787755641028537 CAMK2A,SLC8A3,CAMK2B,RYR2
4.574e-05-9.99pancreas-carcinoid-endocrine_tumourCOSMIC cancer mutationspancreas-carcinoid-endocrine_tumour7250341682847 ABLIM1,NRXN2,FGF14,PPFIA2,CELF5,CAMK2A,DLGAP2,LRRC7,STX1A,GABRB2,PPFIA3,SCN8A,HCN1,SPTBN4,SNAP25,VSNL1,NRG3,SLC8A3,GRIN2B,SPTBN2,CACNA1C,EDIL3,SLC4A10,CAMK2B,PCLO,GRIN1,MCF2L2,CACNA1A,RIMS1,CACNA2D1,NRXN3,RYR2,CACNA1E,SYT1
4.588e-05-9.99perikaryoncellular componentGO:004320415151910850 SLC8A3,CACNA1C,CPLX1,TMEM266,SLC4A10
4.601e-05-9.99signalingbiological processGO:00230524968261820447 EPHA6,CACNA1A,GRM5,CAMK2A,GABRB2,GRIN1,STX1A,GRIN2B,PPFIA3,SNAP25,CACNA1E,CAMK2B,PCLO,RYR2,CACNA1G,RASGRF1,SYT1,NRG3,CACNA1C,RIMS1,FGF14,NRXN2,CPLX1,DLGAP2,DLG4,CACNA2D1
4.606e-05-9.99haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma47681682847 RASGRF1,RIMS1,NRXN3,NRG3,CACNA2D1,PPFIA2,MYT1L,DLGAP2
4.644e-05-9.98glutamate receptor activitymolecular functionGO:00080662631809449 GRIN1,GRIN2B,GRM5
4.644e-05-9.98structural constituent of synapsemolecular functionGO:00989182631809449 SPTBN2,PCLO,PPFIA2
4.690e-05-9.97regulation of vesicle-mediated transportbiological processGO:006062751681820447 PPFIA2,CPLX1,VSNL1,DLG4,STX1A,PCLO,RIMS1,SYT1
4.718e-05-9.96stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableCOSMIC cancer mutationsstomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable951111682847 CACNA1E,MYT1L,NRXN3,CACNA2D1,MCF2L2,PCLO,CACNA1C,CAMK2B,SPTBN2,EPHA6,PPFIA2
4.718e-05-9.96mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiableCOSMIC cancer mutationsmixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable951111682847 EPHA6,SPTBN2,CAMK2B,CACNA1C,PPFIA2,MYT1L,CACNA1E,PCLO,MCF2L2,NRXN3,CACNA2D1
5.002e-05-9.90LRRC7 (leucine rich repeat containing 7)protein interactions575542831945450 CAMK2A,DLG4,LRRC7
5.215e-05-9.86calmodulin-dependent protein kinase activitymolecular functionGO:00046832731809449 CAMK2B,CAMK2A,CAMKV
5.291e-05-9.85astrocytoma_Grade_IIICOSMIC cancer mutationsastrocytoma_Grade_III1544141682847 NRXN3,CACNA2D1,RIMS1,MCF2L2,RASGRF1,PCLO,SPTBN4,HCN1,RYR2,PPFIA2,SLC8A3,NRG3,DLGAP2,EDIL3
5.379e-05-9.83regulation of blood circulationbiological processGO:190352226161820447 RYR2,CACNA1G,CACNA1C,SPTBN4,CACNA2D1,SLC8A3
5.442e-05-9.82Retrograde endocannabinoid signalingKEGG pathwayshsa047231015716130 CACNA1A,CACNA1C,GRM5,GABRB2,RIMS1
5.442e-05-9.82Retrograde endocannabinoid signalingKEGG pathwaysko047231015716130 GABRB2,GRM5,RIMS1,CACNA1A,CACNA1C
5.452e-05-9.82SALM protein interactions at the synapsesREACTOME pathwaysR-HSA-88499322131028537 DLG4,GRIN1,GRIN2B
5.554e-05-9.80haematopoietic_and_lymphoid_tissue-lymphoid_neoplasmCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm7307341682847 DLGAP2,STX1A,LRRC7,CELF5,CAMK2A,ABLIM1,FGF14,PPFIA2,CACNA1G,NRXN2,MYT1L,SPTBN4,HCN1,SCN8A,SPTBN2,CPLX1,CAMK2B,CACNA1C,EDIL3,VSNL1,GRIN2B,NRG3,SLC8A3,CACNA1E,SYT1,RYR2,CACNA1A,RIMS1,PCLO,MCF2L2,RASGRF1,GRIN1,CACNA2D1,NRXN3
5.569e-05-9.80KCNB1 (potassium voltage-gated channel subfamily B member 1)protein interactions37452931945450 SNAP25,CACNA1C,STX1A
5.623e-05-9.79protein heterooligomerizationbiological processGO:00512912931820447 GRIN1,SYT1,GRIN2B
5.703e-05-9.77membranecellular componentGO:00160209220381910850 GRIN2B,CCDC136,GRIN1,GRM5,CACNA2D1,CAMKV,STX1A,DNM1,L1CAM,CAMK2B,NRXN3,SYT1,TMEM266,RYR2,CACNA1E,PPFIA2,DLGAP2,SNAP25,SCN8A,CACNA1A,SPTBN2,EPHA6,CAMK2A,DLG4,CACNA1C,SPTBN4,NRXN2,SLC8A3,LRRC7,RASGRF1,VSNL1,SLC4A10,NRG3,GABRB2,RIMS1,CACNA1G,HCN1,CPLX1
5.927e-05-9.73regulation of biological processbiological processGO:005078912079431820447 MYT1L,CELF3,SLC8A3,SPTBN4,PPFIA3,SNAP25,GRIN2B,CELF5,HCN1,GABRB2,GRIN1,STX1A,EPHA6,CACNA1A,L1CAM,IQSEC2,GRM5,VSNL1,CAMK2A,LRRC7,SPTBN2,DLG4,BRINP1,CAMKV,CACNA2D1,FGF14,DLGAP2,NRXN2,CPLX1,RASGRF1,RIMS1,CACNA1C,NRG3,SYT1,DNM1,SLC4A10,PPFIA2,EDIL3,CACNA1G,RYR2,CAMK2B,CACNA1E,PCLO
6.067e-05-9.71DLG4 (discs large MAGUK scaffold protein 4)protein interactions174216351945450 DLGAP2,GRIN1,GRIN2B,LRRC7,DLG4
6.129e-05-9.70secretionbiological processGO:004690353681820447 NRXN2,CPLX1,STX1A,PCLO,RIMS1,SNAP25,SYT1,PPFIA3
6.442e-05-9.65CAMK2N2 (calcium/calmodulin dependent protein kinase II inhibitor 2)protein interactions94032521945450 CAMK2A,CAMK2B
6.468e-05-9.65membrane dockingbiological processGO:00224068441820447 SNAP25,STX1A,SYT1,PPFIA3
6.490e-05-9.64ligand-gated calcium channel activitymolecular functionGO:00996042931809449 GRIN1,GRIN2B,RYR2
6.492e-05-9.64membrane depolarization during AV node cell action potentialbiological processGO:0086045521820447 CACNA1C,CACNA1G
6.610e-05-9.62haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma2737191682847 RIMS1,SCN8A,PCLO,RASGRF1,CACNA2D1,NRXN3,MYT1L,SYT1,RYR2,FGF14,GRIN2B,PPFIA2,NRG3,SPTBN2,DLGAP2,LRRC7,CAMK2B,EDIL3,CELF5
6.677e-05-9.61synaptobrevin 2-SNAP-25-syntaxin-1a complexcellular componentGO:0070044521910850 SNAP25,STX1A
6.677e-05-9.61calcium- and calmodulin-dependent protein kinase complexcellular componentGO:0005954521910850 CAMK2B,CAMK2A
6.715e-05-9.61oesophagus-middle_third-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsoesophagus-middle_third-carcinoma-squamous_cell_carcinoma3531221682847 CACNA1C,SLC4A10,NRG3,GRM5,CACNA1E,RYR2,L1CAM,NRXN3,RIMS1,CACNA1A,DLG4,MCF2L2,RASGRF1,PCLO,LRRC7,DLGAP2,CAMK2A,PPFIA2,CACNA1G,ABLIM1,HCN1,SCN8A
6.719e-05-9.61Spectrin/alpha-actinininterpro domainsIPR0181593031852149 MCF2L2,SPTBN2,SPTBN4
6.739e-05-9.61MAPK signaling pathwayKEGG pathwaysko040102557716130 CACNA1A,CACNA1C,CACNA2D1,RASGRF1,FGF14,CACNA1E,CACNA1G
6.739e-05-9.61MAPK signaling pathwayKEGG pathwayshsa040102557716130 CACNA1G,CACNA1E,CACNA2D1,CACNA1C,CACNA1A,RASGRF1,FGF14
6.775e-05-9.60middle_thirdCOSMIC cancer mutationsmiddle_third3533221682847 NRG3,GRM5,SLC4A10,CACNA1C,NRXN3,CACNA1A,RIMS1,RASGRF1,DLG4,MCF2L2,PCLO,CACNA1E,RYR2,L1CAM,PPFIA2,CACNA1G,ABLIM1,LRRC7,DLGAP2,CAMK2A,SCN8A,HCN1
6.892e-05-9.58protein localization to postsynaptic membranebiological processGO:19035393131820447 DLG4,LRRC7,SNAP25
6.910e-05-9.58PH_domaininterpro domainsIPR00184926661852149 DNM1,IQSEC2,SPTBN4,SPTBN2,MCF2L2,RASGRF1
7.459e-05-9.50cellular component biogenesisbiological processGO:00440852716181820447 GRIN1,HCN1,GABRB2,ABLIM1,CCDC136,PCLO,SPTBN2,CELF3,DLG4,NRXN2,SPTBN4,RIMS1,SNAP25,SYT1,NRG3,DNM1,CELF5,GRIN2B
7.555e-05-9.49boneCOSMIC cancer mutationsbone8157361682847 NRXN2,FGF14,CACNA1G,PPFIA2,ABLIM1,DLGAP2,GABRB2,LRRC7,EPHA6,PPFIA3,SCN8A,HCN1,CAMKV,SPTBN4,MYT1L,NRG3,SLC8A3,GRIN2B,CCDC136,CACNA1C,EDIL3,SLC4A10,CAMK2B,SPTBN2,NRXN3,CACNA2D1,PCLO,RASGRF1,DLG4,GRIN1,RIMS1,CACNA1A,RYR2,CACNA1E,SYT1,L1CAM
7.591e-05-9.49protein localization to postsynapsebiological processGO:00622373231820447 DLG4,SNAP25,LRRC7
8.422e-05-9.38secretory vesiclecellular componentGO:00995031076111910850 GRIN1,CCDC136,PPFIA2,STX1A,CACNA2D1,SNAP25,DLG4,PPFIA3,DNM1,LRRC7,SYT1
8.981e-05-9.32voltage-gated potassium channel complexcellular componentGO:00080769041910850 DLG4,SNAP25,HCN1,STX1A
9.125e-05-9.30exploration behaviorbiological processGO:00356403431820447 BRINP1,DLG4,SLC4A10
9.227e-05-9.29protein tetramerizationbiological processGO:00512629241820447 GRIN1,HCN1,DNM1,GRIN2B
9.527e-05-9.26central_nervous_system-brain-glioma-astrocytoma_Grade_IIICOSMIC cancer mutationscentral_nervous_system-brain-glioma-astrocytoma_Grade_III1419131682847 PPFIA2,NRG3,SLC8A3,DLGAP2,EDIL3,CACNA2D1,NRXN3,RIMS1,PCLO,MCF2L2,RASGRF1,RYR2,HCN1
9.647e-05-9.25NLGN4X (neuroligin 4 X-linked)protein interactions57502621945450 DLGAP2,DLG4
1.011e-04-9.20PRNP (prion protein (Kanno blood group))protein interactions56211118111945450 CPLX1,GRM5,DNM1,SLC4A10,CAMK2B,CAMK2A,SYT1,IQSEC2,L1CAM,ABLIM1,DLG4
1.022e-04-9.19Liprininterpro domainsIPR029515621852149 PPFIA2,PPFIA3
1.022e-04-9.19PH_dom-spectrin-typeinterpro domainsIPR001605621852149 SPTBN4,SPTBN2
1.040e-04-9.17cell cortex regioncellular componentGO:00997383531910850 PPFIA3,RIMS1,PCLO
1.070e-04-9.14glutamate-gated calcium ion channel activitymolecular functionGO:0022849621809449 GRIN1,GRIN2B
1.071e-04-9.14-gene3d domains6.10.140.620521447048 CAMK2B,CAMK2A
1.071e-04-9.14Nicotine Activity on Chromaffin CellsWikiPathwaysWP160342531023 CACNA1G,CACNA1C
1.085e-04-9.13positive regulation of synaptic transmission, glutamatergicbiological processGO:00519683631820447 GRIN1,IQSEC2,GRIN2B
1.118e-04-9.10skin-extremity-malignant_melanomaCOSMIC cancer mutationsskin-extremity-malignant_melanoma1875151682847 EPHA6,CACNA1C,CAMK2A,CAMK2B,GRIN2B,MYT1L,RYR2,HCN1,CACNA1E,SNAP25,SPTBN4,SYT1,RIMS1,NRXN3,CACNA2D1
1.125e-04-9.09extremityCOSMIC cancer mutationsextremity1876151682847 RIMS1,NRXN3,CACNA2D1,MYT1L,SYT1,SPTBN4,CACNA1E,SNAP25,HCN1,RYR2,GRIN2B,EPHA6,CAMK2B,CAMK2A,CACNA1C
1.154e-04-9.07sarcoplasmcellular componentGO:00165289641910850 SLC8A3,CAMK2B,CACNA2D1,RYR2
1.155e-04-9.07mantle_cell_lymphomaCOSMIC cancer mutationsmantle_cell_lymphoma2849191682847 PPFIA2,FGF14,GRIN2B,NRG3,SPTBN2,LRRC7,CAMK2B,DLGAP2,CELF5,EDIL3,RIMS1,RASGRF1,PCLO,SCN8A,NRXN3,CACNA2D1,MYT1L,SYT1,RYR2
1.167e-04-9.06GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D)protein interactions29063731945450 DLG4,GRIN1,DNM1
1.190e-04-9.04STX1A (syntaxin 1A)protein interactions680418851945450 CPLX1,SNAP25,SYT1,STX1A,RIMS1
1.249e-04-8.99MAPT (microtubule associated protein tau)protein interactions4137948101945450 RIMS1,SPTBN2,SYT1,CAMK2A,DNM1,SNAP25,PPFIA2,PPFIA3,CAMK2B,ABLIM1
1.260e-04-8.98ANF_receptorpfam domainsPF010943731779547 GRIN2B,GRIN1,GRM5
1.269e-04-8.97ANF_lig-bd_rcptinterpro domainsIPR0018283731852149 GRIN2B,GRIN1,GRM5
1.276e-04-8.97oesophagus-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsoesophagus-carcinoma-squamous_cell_carcinoma6486311682847 NRG3,SLC8A3,GRIN2B,GRM5,EDIL3,SLC4A10,CACNA1C,CAMK2B,SPTBN2,NRXN3,CACNA2D1,PCLO,RASGRF1,DLG4,CACNA1A,RIMS1,RYR2,NRXN2,FGF14,CACNA1G,PPFIA2,ABLIM1,DLGAP2,GABRB2,LRRC7,EPHA6,PPFIA3,CAMKV,HCN1,SPTBN4,MYT1L
1.296e-04-8.95adenomaCOSMIC cancer mutationsadenoma2873191682847 EDIL3,CACNA1C,SLC4A10,DLGAP2,LRRC7,GABRB2,SPTBN2,SLC8A3,IQSEC2,FGF14,HCN1,CACNA1E,SYT1,MYT1L,NRXN3,CACNA2D1,PCLO,GRIN1,RASGRF1
1.320e-04-8.93autonomic_ganglia-neuroblastomaCOSMIC cancer mutationsautonomic_ganglia-neuroblastoma3970231682847 HCN1,SPTBN4,MYT1L,SCN8A,CAMK2A,LRRC7,GABRB2,IQSEC2,PPFIA2,RYR2,CACNA1E,L1CAM,PCLO,MCF2L2,RASGRF1,CACNA1A,RIMS1,CACNA1C,SLC4A10,CELF3,SPTBN2,GRIN2B,GRM5
1.326e-04-8.93neuroblastomaCOSMIC cancer mutationsneuroblastoma3971231682847 PPFIA2,IQSEC2,GABRB2,LRRC7,CAMK2A,SCN8A,SPTBN4,HCN1,MYT1L,GRIN2B,GRM5,CACNA1C,SLC4A10,SPTBN2,CELF3,CACNA1A,RIMS1,MCF2L2,RASGRF1,PCLO,CACNA1E,RYR2,L1CAM
1.353e-04-8.91soft_tissueCOSMIC cancer mutationssoft_tissue5828291682847 NRXN2,FGF14,CACNA1G,PPFIA2,EPHA6,CAMK2A,DLGAP2,GABRB2,LRRC7,MYT1L,HCN1,SPTBN4,NRG3,SLC8A3,GRIN2B,SPTBN2,EDIL3,CACNA1C,CAMK2B,PCLO,MCF2L2,DLG4,CACNA1A,RIMS1,NRXN3,CACNA2D1,L1CAM,RYR2,CACNA1E
1.359e-04-8.90AV node cell to bundle of His cell signalingbiological processGO:0086027721820447 CACNA1C,CACNA1G
1.359e-04-8.90AV node cell action potentialbiological processGO:0086016721820447 CACNA1G,CACNA1C
1.362e-04-8.90regulation of monoatomic cation transmembrane transportbiological processGO:190406230961820447 GRIN2B,CACNA1C,RYR2,FGF14,GRIN1,CACNA2D1
1.363e-04-8.90adrenal_glandCOSMIC cancer mutationsadrenal_gland2628181682847 L1CAM,MYT1L,RYR2,HCN1,SCN8A,PCLO,GRIN1,CACNA1A,RIMS1,NRXN3,EPHA6,SPTBN2,SLC4A10,CACNA1C,CCDC136,GRM5,NRG3,NRXN2
1.367e-04-8.90neurotransmitter receptor activitymolecular functionGO:00305949741809449 GRIN2B,GABRB2,GRIN1,GRM5
1.376e-04-8.89cytoplasmic vesiclecellular componentGO:00314102521171910850 LRRC7,CAMK2B,SYT1,GABRB2,SNAP25,CAMKV,STX1A,CACNA2D1,SCN8A,CAMK2A,PPFIA2,GRIN2B,CCDC136,GRIN1,DNM1,PPFIA3,DLG4
1.405e-04-8.87potassium channel complexcellular componentGO:003470510141910850 DLG4,STX1A,SNAP25,HCN1
1.413e-04-8.86cAMP signaling pathwayKEGG pathwayshsa040241986716130 GRIN2B,RYR2,CAMK2B,GRIN1,CAMK2A,CACNA1C
1.413e-04-8.86cAMP signaling pathwayKEGG pathwaysko040241986716130 CAMK2A,CACNA1C,RYR2,GRIN2B,CAMK2B,GRIN1
1.417e-04-8.86intracellular vesiclecellular componentGO:00977082527171910850 GABRB2,SYT1,LRRC7,CAMK2B,PPFIA3,DNM1,DLG4,CAMKV,CACNA2D1,STX1A,SNAP25,CAMK2A,SCN8A,CCDC136,PPFIA2,GRIN2B,GRIN1
1.424e-04-8.86bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumourCOSMIC cancer mutationsbone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour891101682847 CACNA2D1,RIMS1,CACNA1A,ABLIM1,GRIN1,CACNA1E,SPTBN4,LRRC7,MYT1L,EPHA6
1.437e-04-8.85ligand-gated monoatomic ion channel activitymolecular functionGO:001527618651809449 RYR2,GABRB2,HCN1,GRIN1,GRIN2B
1.474e-04-8.82ligand-gated channel activitymolecular functionGO:002283418751809449 GABRB2,HCN1,GRIN1,GRIN2B,RYR2
1.487e-04-8.81Peripla_BP_Iinterpro domainsIPR0280823931852149 GRIN2B,GRM5,GRIN1
1.490e-04-8.81regulation of heart rate by cardiac conductionbiological processGO:00860914031820447 CACNA2D1,CACNA1G,CACNA1C
1.496e-04-8.81NMDA glutamate receptor activitymolecular functionGO:0004972721809449 GRIN1,GRIN2B
1.496e-04-8.81locomotory behaviorbiological processGO:000762619751820447 SNAP25,SLC4A10,DLG4,GRM5,SPTBN4
1.498e-04-8.81skin-trunk-malignant_melanomaCOSMIC cancer mutationsskin-trunk-malignant_melanoma2647181682847 L1CAM,MYT1L,RYR2,HCN1,CACNA1E,NRXN3,CACNA2D1,SPTBN2,EPHA6,EDIL3,CACNA1C,VSNL1,NRG3,NRXN2,SLC8A3,IQSEC2,GRIN2B,PPFIA2
1.521e-04-8.79autonomic_gangliaCOSMIC cancer mutationsautonomic_ganglia4005231682847 HCN1,SPTBN4,MYT1L,SCN8A,CAMK2A,LRRC7,GABRB2,PPFIA2,IQSEC2,RYR2,CACNA1E,L1CAM,RASGRF1,MCF2L2,PCLO,CACNA1A,RIMS1,SLC4A10,CACNA1C,CELF3,SPTBN2,GRIN2B,GRM5
1.589e-04-8.75extraskeletalCOSMIC cancer mutationsextraskeletal903101682847 SPTBN4,CACNA1E,LRRC7,EPHA6,MYT1L,CACNA2D1,RIMS1,CACNA1A,ABLIM1,GRIN1
1.609e-04-8.73actin filament-based processbiological processGO:003002961681820447 IQSEC2,SPTBN4,CACNA2D1,SPTBN2,SCN8A,RYR2,CACNA1C,CACNA1G
1.676e-04-8.69ionotropic glutamate receptor complexcellular componentGO:00083284131910850 GRIN1,GRIN2B,DLG4
1.743e-04-8.65CASK (calcium/calmodulin dependent serine protein kinase)protein interactions857320451945450 DLG4,DLGAP2,ABLIM1,NRXN3,NRXN2
1.797e-04-8.62Uptake and actions of bacterial toxinsREACTOME pathwaysR-HSA-53395623131028537 SYT1,SNAP25,STX1A
1.807e-04-8.62Dopaminergic synapseKEGG pathwaysko047281305716130 CACNA1C,CACNA1A,CAMK2A,CAMK2B,GRIN2B
1.807e-04-8.62Dopaminergic synapseKEGG pathwayshsa047281305716130 GRIN2B,CAMK2B,CACNA1C,CACNA1A,CAMK2A
1.851e-04-8.59regulation of synaptic vesicle exocytosisbiological processGO:20003004331820447 PPFIA2,RIMS1,SYT1
1.860e-04-8.59cytoskeleton of presynaptic active zonecellular componentGO:0048788821910850 RIMS1,PCLO
1.893e-04-8.57PH_9pfam domainsPF15410821779547 SPTBN4,SPTBN2
1.901e-04-8.57PH_9interpro domainsIPR041681821852149 SPTBN2,SPTBN4
1.902e-04-8.57pharynxCOSMIC cancer mutationspharynx2696181682847 RASGRF1,PCLO,SCN8A,RIMS1,CACNA1A,NRXN3,MYT1L,HCN1,RYR2,CACNA1E,GRM5,SLC8A3,NRXN2,NRG3,PPFIA2,GRIN2B,IQSEC2,STX1A
1.977e-04-8.53RNF123 (ring finger protein 123)protein interactions6389181291945450 GRIN1,PPFIA2,PPFIA3,IQSEC2,LRRC7,SCN8A,HCN1,PCLO,SPTBN2
1.978e-04-8.53Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOME pathwaysR-HSA-3997213231028537 CAMK2A,CAMK2B,DLG4
1.978e-04-8.53Trafficking of AMPA receptorsREACTOME pathwaysR-HSA-3997193231028537 DLG4,CAMK2B,CAMK2A
1.983e-04-8.53cellular response to amyloid-betabiological processGO:19046464431820447 CACNA1A,CACNA2D1,GRIN1
1.983e-04-8.53receptor localization to synapsebiological processGO:00971204431820447 DLG4,LRRC7,SNAP25
1.991e-04-8.52glutamate bindingmolecular functionGO:0016595821809449 GRIN1,GRIN2B
2.044e-04-8.50regulation of regulated secretory pathwaybiological processGO:190330511341820447 SYT1,STX1A,RIMS1,PPFIA2
2.050e-04-8.49urinary_tract-bladder-carcinomaCOSMIC cancer mutationsurinary_tract-bladder-carcinoma14050471682847 CAMK2A,LRRC7,STX1A,GABRB2,EPHA6,NRXN2,PPFIA2,FGF14,IQSEC2,HCN1,SNAP25,MYT1L,DNM1,SCN8A,EDIL3,SLC4A10,CACNA1C,CAMK2B,CPLX1,CELF3,SPTBN2,SLC8A3,CCDC136,SYT1,L1CAM,CACNA2D1,GRIN1,MCF2L2,DLG4,CELF5,DLGAP2,CACNA1G,ABLIM1,CAMKV,SPTBN4,PPFIA3,NRG3,GRIN2B,GRM5,VSNL1,RYR2,CACNA1E,NRXN3,RASGRF1,PCLO,CACNA1A,RIMS1
2.059e-04-8.49CALM3 (calmodulin 3)protein interactions80833461945450 CAMK2A,CACNA1A,IQSEC2,GRM5,EPHA6,CAMK2B
2.068e-04-8.48SPECTRINPHprints domainsPR0068362522720 SPTBN2,SPTBN4
2.081e-04-8.48-gene3d domains1.20.58.603531447048 SPTBN4,MCF2L2,SPTBN2
2.088e-04-8.47regulation of cellular processbiological processGO:005079411468411820447 SPTBN4,MYT1L,CELF3,SLC8A3,GRIN2B,CELF5,PPFIA3,SNAP25,L1CAM,CACNA1A,EPHA6,IQSEC2,GRM5,VSNL1,CAMK2A,HCN1,STX1A,GRIN1,SPTBN2,LRRC7,FGF14,DLGAP2,CPLX1,NRXN2,BRINP1,DLG4,CAMKV,CACNA2D1,DNM1,RASGRF1,CACNA1C,RIMS1,NRG3,SYT1,PPFIA2,EDIL3,SLC4A10,CAMK2B,PCLO,CACNA1G,RYR2
2.093e-04-8.47axon terminuscellular componentGO:004367911241910850 SLC8A3,GRIN1,CPLX1,SLC4A10
2.121e-04-8.46glutamate receptor signaling pathwaybiological processGO:00072154531820447 GRM5,GRIN2B,GRIN1
2.193e-04-8.43SPECsmart domainsSM00150293971740 SPTBN2,SPTBN4,MCF2L2
2.254e-04-8.40haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasmCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm76491682847 SYT1,CAMK2B,RYR2,HCN1,RIMS1,PCLO,GRIN2B,PPFIA2,NRG3
2.265e-04-8.39receptor clusteringbiological processGO:00431134631820447 NRXN2,DLG4,LRRC7
2.273e-04-8.39CAMK2G (calcium/calmodulin dependent protein kinase II gamma)protein interactions81821651945450 GRIN2B,GRIN1,LRRC7,CAMK2B,CAMK2A
2.281e-04-8.39regulation of transmembrane transportbiological processGO:003476248571820447 GRIN2B,CACNA1C,RYR2,FGF14,GRIN1,CACNA2D1,DLG4
2.304e-04-8.38NETO1 (neuropilin and tolloid like 1)protein interactions81832921945450 GRIN2B,GRIN1
2.322e-04-8.37synaptic vesicle dockingbiological processGO:0016081921820447 SNAP25,PPFIA3
2.364e-04-8.35neurotransmitter receptor complexcellular componentGO:00988784631910850 GRIN1,DLG4,GRIN2B
2.388e-04-8.34NMDA selective glutamate receptor complexcellular componentGO:0017146921910850 GRIN2B,GRIN1
2.388e-04-8.34spectrincellular componentGO:0008091921910850 SPTBN4,SPTBN2
2.413e-04-8.33positive regulation of calcium ion transportbiological processGO:005192811841820447 CAMK2A,RYR2,CACNA2D1,GRIN1
2.415e-04-8.33regulation of neuron migrationbiological processGO:20012224731820447 CAMK2A,CAMK2B,NRG3
2.434e-04-8.32Cytokine Signaling in Immune systemREACTOME pathwaysR-HSA-1280215756101028537 GRIN2B,CAMK2A,SPTBN2,GRIN1,RASGRF1,NRG3,SPTBN4,STX1A,DLG4,CAMK2B
2.522e-04-8.29bladderCOSMIC cancer mutationsbladder14112471682847 DLGAP2,CELF5,ABLIM1,CACNA1G,SPTBN4,CAMKV,PPFIA3,VSNL1,GRM5,GRIN2B,NRG3,CACNA1E,RYR2,CACNA1A,RIMS1,PCLO,RASGRF1,NRXN3,EPHA6,GABRB2,LRRC7,STX1A,CAMK2A,IQSEC2,FGF14,PPFIA2,NRXN2,MYT1L,SNAP25,HCN1,SCN8A,DNM1,SPTBN2,CELF3,CPLX1,CAMK2B,CACNA1C,EDIL3,SLC4A10,CCDC136,SLC8A3,L1CAM,SYT1,GRIN1,DLG4,MCF2L2,CACNA2D1
2.522e-04-8.29urinary_tractCOSMIC cancer mutationsurinary_tract14112471682847 ABLIM1,CACNA1G,DLGAP2,CELF5,PPFIA3,SPTBN4,CAMKV,GRM5,VSNL1,GRIN2B,NRG3,CACNA1A,RIMS1,RASGRF1,PCLO,NRXN3,CACNA1E,RYR2,PPFIA2,FGF14,IQSEC2,NRXN2,EPHA6,LRRC7,STX1A,GABRB2,CAMK2A,SCN8A,DNM1,MYT1L,SNAP25,HCN1,CCDC136,SLC8A3,SPTBN2,CELF3,CAMK2B,CPLX1,EDIL3,SLC4A10,CACNA1C,GRIN1,MCF2L2,DLG4,CACNA2D1,L1CAM,SYT1
2.552e-04-8.27regulation of monoatomic ion transmembrane transportbiological processGO:003476534761820447 GRIN2B,RYR2,CACNA1C,FGF14,CACNA2D1,GRIN1
2.571e-04-8.27insulin secretionbiological processGO:00300734831820447 STX1A,CPLX1,PCLO
2.724e-04-8.21Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumourCOSMIC cancer mutationsEwings_sarcoma-peripheral_primitive_neuroectodermal_tumour7434331682847 EPHA6,DLGAP2,LRRC7,GABRB2,ABLIM1,FGF14,CACNA1G,PPFIA2,NRXN2,MYT1L,SPTBN4,CAMKV,PPFIA3,SCN8A,SPTBN2,CAMK2B,EDIL3,SLC4A10,CACNA1C,CCDC136,GRIN2B,NRG3,SLC8A3,L1CAM,CACNA1E,RYR2,RIMS1,CACNA1A,PCLO,GRIN1,DLG4,NRXN3,CACNA2D1
2.728e-04-8.21regulation of cellular component organizationbiological processGO:00511282455161820447 DLG4,CAMKV,SPTBN4,CPLX1,SNAP25,RIMS1,NRG3,SYT1,GRIN2B,STX1A,PPFIA2,L1CAM,IQSEC2,LRRC7,CAMK2B,SPTBN2
2.783e-04-8.19glutamate receptor bindingmolecular functionGO:00352544731809449 CAMK2A,RASGRF1,DLG4
2.914e-04-8.14Adrenergic signaling in cardiomyocytesKEGG pathwaysko042611445716130 CAMK2B,RYR2,CACNA2D1,CACNA1C,CAMK2A
2.914e-04-8.14Adrenergic signaling in cardiomyocytesKEGG pathwayshsa042611445716130 RYR2,CAMK2B,CACNA1C,CACNA2D1,CAMK2A
2.916e-04-8.14cellular response to organonitrogen compoundbiological processGO:007141750571820447 RYR2,GRIN1,CACNA2D1,HCN1,GABRB2,CAMK2A,CACNA1A
2.986e-04-8.12PDZpfam domainsPF0059512241779547 LRRC7,PCLO,RIMS1,DLG4
3.007e-04-8.11memorybiological processGO:000761312541820447 BRINP1,RASGRF1,SNAP25,SLC8A3
3.030e-04-8.10SNARE complexcellular componentGO:00312015031910850 CPLX1,SNAP25,STX1A
3.143e-04-8.07lymphoid_neoplasmCOSMIC cancer mutationslymphoid_neoplasm12233441682847 CELF5,CAMK2A,DLGAP2,LRRC7,STX1A,GABRB2,EPHA6,NRXN2,FGF14,CACNA1G,PPFIA2,ABLIM1,CAMKV,HCN1,SPTBN4,SNAP25,MYT1L,DNM1,SCN8A,PPFIA3,CACNA1C,EDIL3,SLC4A10,CPLX1,CAMK2B,SPTBN2,NRG3,SLC8A3,GRIN2B,CCDC136,VSNL1,GRM5,RYR2,CACNA1E,SYT1,L1CAM,NRXN3,CACNA2D1,PCLO,GRIN1,MCF2L2,RASGRF1,CACNA1A,RIMS1
3.266e-04-8.03protein-containing complex assemblybiological processGO:00650031279111820447 HCN1,GRIN1,CELF5,GRIN2B,DNM1,SYT1,SNAP25,RIMS1,SPTBN4,DLG4,CELF3
3.334e-04-8.01cell developmentbiological processGO:00484682236151820447 RASGRF1,SNAP25,MYT1L,BRINP1,DLG4,SLC8A3,SPTBN4,NRXN3,CCDC136,GABRB2,HCN1,SLC4A10,L1CAM,EPHA6,CAMK2A
3.355e-04-8.00vesicle-mediated transportbiological processGO:00161921283111820447 SPTBN4,CPLX1,PPFIA3,SYT1,SNAP25,RIMS1,DNM1,STX1A,LRRC7,SPTBN2,PCLO
3.489e-04-7.96Aldosterone synthesis and secretionKEGG pathwayshsa04925824716130 CACNA1C,CACNA1G,CAMK2A,CAMK2B
3.489e-04-7.96Aldosterone synthesis and secretionKEGG pathwaysko04925824716130 CAMK2B,CAMK2A,CACNA1G,CACNA1C
3.508e-04-7.96CACNA1D (calcium voltage-gated channel subunit alpha1 D)protein interactions7761121945450 STX1A,RYR2
3.508e-04-7.96ITPKA (inositol-trisphosphate 3-kinase A)protein interactions37061121945450 CAMK2B,CAMK2A
3.508e-04-7.96Cobll1 (Cobl-like 1)protein interactions3198761121945450 ABLIM1,BRINP1
3.572e-04-7.94EPH-Ephrin signalingREACTOME pathwaysR-HSA-26823349541028537 EPHA6,DNM1,GRIN1,GRIN2B
3.575e-04-7.94neuron projection developmentbiological processGO:003117569381820447 EPHA6,L1CAM,SPTBN4,CAMK2A,DLG4,RASGRF1,SNAP25,NRXN3
3.591e-04-7.93muscle contractionbiological processGO:000693623851820447 RYR2,CACNA2D1,CACNA1C,CACNA1G,SCN8A
3.613e-04-7.93NOS1 (nitric oxide synthase 1)protein interactions48425431945450 CAMK2A,DLG4,DLGAP2
3.636e-04-7.92presynaptic cytoskeletoncellular componentGO:00995691121910850 PCLO,RIMS1
3.699e-04-7.90SBP_bac_3pfam domainsPF004971121779547 GRIN2B,GRIN1
3.714e-04-7.90Solute-binding_3/MltF_Ninterpro domainsIPR0016381121852149 GRIN2B,GRIN1
3.744e-04-7.89Oxytocin signaling pathwayKEGG pathwayshsa049211525716130 RYR2,CAMK2B,CACNA2D1,CACNA1C,CAMK2A
3.744e-04-7.89Oxytocin signaling pathwayKEGG pathwaysko049211525716130 CACNA2D1,CACNA1C,CAMK2A,CAMK2B,RYR2
3.851e-04-7.86membrane depolarizationbiological processGO:00518995531820447 CACNA1G,CACNA1C,CACNA2D1
3.851e-04-7.86synaptic vesicle endocytosisbiological processGO:00484885531820447 DNM1,SYT1,STX1A
3.890e-04-7.85glycine bindingmolecular functionGO:00165941121809449 GRIN1,GRIN2B
4.062e-04-7.81response to amyloid-betabiological processGO:19046455631820447 GRIN1,CACNA2D1,CACNA1A
4.062e-04-7.81presynaptic endocytosisbiological processGO:01402385631820447 STX1A,SYT1,DNM1
4.130e-04-7.79organelle localizationbiological processGO:005164053571820447 SYT1,SNAP25,STX1A,PPFIA3,DNM1,PCLO,PPFIA2
4.139e-04-7.79upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinomaCOSMIC cancer mutationsupper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma1425121682847 GRM5,NRXN2,SLC8A3,GRIN2B,IQSEC2,PPFIA2,MYT1L,RYR2,CACNA1E,PCLO,RIMS1,CACNA1A
4.139e-04-7.79nasopharyngeal_carcinomaCOSMIC cancer mutationsnasopharyngeal_carcinoma1425121682847 GRM5,PPFIA2,GRIN2B,IQSEC2,SLC8A3,NRXN2,CACNA1A,RIMS1,PCLO,MYT1L,CACNA1E,RYR2
4.175e-04-7.78oesophagus-carcinomaCOSMIC cancer mutationsoesophagus-carcinoma4269231682847 L1CAM,MYT1L,RYR2,HCN1,CACNA1E,PCLO,PPFIA3,MCF2L2,DLG4,RASGRF1,RIMS1,CACNA1A,NRXN3,CACNA1C,SLC4A10,CAMK2B,LRRC7,GRM5,NRG3,GRIN2B,IQSEC2,CACNA1G,PPFIA2
4.236e-04-7.77positive regulation of catecholamine secretionbiological processGO:00336051221820447 STX1A,SYT1
4.236e-04-7.77regulation of synaptic vesicle fusion to presynaptic active zone membranebiological processGO:00316301221820447 CPLX1,SYT1
4.236e-04-7.77excitatory chemical synaptic transmissionbiological processGO:00989761221820447 GRIN2B,GRIN1
4.236e-04-7.77synaptic vesicle fusion to presynaptic active zone membranebiological processGO:00316291221820447 STX1A,SNAP25
4.236e-04-7.77regulation of synaptic vesicle membrane organizationbiological processGO:19016321221820447 CPLX1,SYT1
4.236e-04-7.77regulation of ventricular cardiac muscle cell action potentialbiological processGO:00989111221820447 RYR2,CACNA1C
4.236e-04-7.77AV node cell to bundle of His cell communicationbiological processGO:00860671221820447 CACNA1C,CACNA1G
4.355e-04-7.74juxtaparanode region of axoncellular componentGO:00442241221910850 DLG4,SPTBN4
4.355e-04-7.74L-type voltage-gated calcium channel complexcellular componentGO:19904541221910850 CACNA2D1,CACNA1C
4.379e-04-7.73sodium ion transmembrane transportbiological processGO:003572513841820447 SCN8A,SLC4A10,HCN1,SLC8A3
4.463e-04-7.71positive regulation of cell communicationbiological processGO:00106471792131820447 IQSEC2,CAMK2A,VSNL1,GRM5,GRIN1,STX1A,DLG4,SLC8A3,GRIN2B,RASGRF1,RIMS1,SNAP25,SYT1
4.511e-04-7.70positive regulation of signalingbiological processGO:00230561794131820447 STX1A,GRIN1,GRM5,CAMK2A,VSNL1,IQSEC2,SYT1,SNAP25,RIMS1,RASGRF1,GRIN2B,SLC8A3,DLG4
4.702e-04-7.66ARHGAP32 (Rho GTPase activating protein 32)protein interactions974314141945450 CAMK2A,EPHA6,GRIN2B,DLG4
4.829e-04-7.64GIT1 (GIT ArfGAP 1)protein interactions2896414241945450 PPFIA2,PPFIA3,CAMK2A,PCLO
4.841e-04-7.63ligand-gated monoatomic cation channel activitymolecular functionGO:009909413541809449 GRIN2B,HCN1,GRIN1,RYR2
4.853e-04-7.63prostate-carcinoma-adenocarcinomaCOSMIC cancer mutationsprostate-carcinoma-adenocarcinoma12379441682847 CACNA1C,EDIL3,SLC4A10,CAMK2B,CPLX1,CELF3,SPTBN2,SLC8A3,NRG3,GRIN2B,CCDC136,GRM5,VSNL1,RYR2,SYT1,CACNA1E,L1CAM,CACNA2D1,NRXN3,GRIN1,DLG4,MCF2L2,RASGRF1,PCLO,CACNA1A,RIMS1,CAMK2A,CELF5,GABRB2,STX1A,LRRC7,DLGAP2,EPHA6,NRXN2,CACNA1G,PPFIA2,FGF14,ABLIM1,HCN1,SPTBN4,SNAP25,MYT1L,SCN8A,PPFIA3
4.959e-04-7.61CABP1 (calcium binding protein 1)protein interactions94781321945450 CACNA1C,CACNA1A
4.978e-04-7.61transmission of nerve impulsebiological processGO:00192266031820447 SCN8A,SPTBN4,HCN1
4.978e-04-7.61regulation of action potentialbiological processGO:00989006031820447 RYR2,CACNA2D1,CACNA1C
4.998e-04-7.60positive regulation of calcium ion-dependent exocytosisbiological processGO:00459561321820447 STX1A,SYT1
4.998e-04-7.60vesicle fusion to plasma membranebiological processGO:00995001321820447 SNAP25,STX1A
4.998e-04-7.60detection of calcium ionbiological processGO:00055131321820447 SYT1,RYR2
5.009e-04-7.60protein complex oligomerizationbiological processGO:005125925651820447 GRIN2B,DNM1,HCN1,GRIN1,SYT1
5.040e-04-7.59PRKCA (protein kinase C alpha)protein interactions557839561945450 GRIN2B,GRIN1,DLG4,GRM5,SNAP25,DNM1
5.137e-04-7.57PLCG1 (phospholipase C gamma 1)protein interactions533525851945450 DLGAP2,GRIN1,GRIN2B,DNM1,CAMK2A
5.164e-04-7.57sarcolemmacellular componentGO:004238314241910850 CACNA1C,SLC8A3,RYR2,CACNA2D1
5.227e-04-7.56exocytic processbiological processGO:01400296131820447 SNAP25,STX1A,PPFIA3
5.250e-04-7.55VGCC_Ca_Nainterpro domainsIPR0432031321852149 SCN8A,CACNA1G
5.382e-04-7.53human chr7q21.11chromosome locationhuman chr7q21.111822613450 CACNA2D1,PCLO
5.418e-04-7.52adult behaviorbiological processGO:003053414641820447 NRXN3,NRXN2,SPTBN2,SPTBN4
5.454e-04-7.51transmitter-gated channel activitymolecular functionGO:00228355931809449 GABRB2,GRIN2B,GRIN1
5.454e-04-7.51transmitter-gated monoatomic ion channel activitymolecular functionGO:00228245931809449 GABRB2,GRIN2B,GRIN1
5.482e-04-7.51regulation of postsynaptic membrane neurotransmitter receptor levelsbiological processGO:00990726231820447 SNAP25,LRRC7,DLG4
5.691e-04-7.47NLGN2 (neuroligin 2)protein interactions575556331945450 NRXN3,NRXN2,DLG4
5.746e-04-7.46synaptic vesicle recyclingbiological processGO:00364656331820447 STX1A,SYT1,DNM1
5.821e-04-7.45neurotransmitter receptor transport to postsynaptic membranebiological processGO:00989691421820447 LRRC7,SNAP25
5.879e-04-7.44haematopoietic_and_lymphoid_tissueCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue14368471682847 NRG3,GRIN2B,VSNL1,GRM5,RYR2,CACNA1E,NRXN3,PCLO,RASGRF1,CACNA1A,RIMS1,CELF5,DLGAP2,CACNA1G,ABLIM1,CAMKV,SPTBN4,PPFIA3,SLC4A10,EDIL3,CACNA1C,CPLX1,CAMK2B,CELF3,SPTBN2,SLC8A3,CCDC136,SYT1,L1CAM,CACNA2D1,MCF2L2,GRIN1,DLG4,CAMK2A,LRRC7,STX1A,GABRB2,EPHA6,NRXN2,FGF14,IQSEC2,PPFIA2,HCN1,SNAP25,MYT1L,DNM1,SCN8A
5.961e-04-7.43PDZinterpro domainsIPR00147814641852149 DLG4,RIMS1,PCLO,LRRC7
5.985e-04-7.42chromaffin granulecellular componentGO:00425831421910850 SYT1,DNM1
6.018e-04-7.42-gene3d domains3.40.50.23005031447048 GRIN1,GRM5,GRIN2B
6.066e-04-7.41PHsmart domainsSM002332596971740 IQSEC2,MCF2L2,DNM1,SPTBN4,RASGRF1,SPTBN2
6.114e-04-7.40Neurexin-likeinterpro domainsIPR0035851421852149 NRXN3,NRXN2
6.136e-04-7.40SAM_1pfam domainsPF005366331779547 EPHA6,PPFIA2,PPFIA3
6.298e-04-7.37long-term synaptic potentiationbiological processGO:00602916531820447 GRIN2B,SLC8A3,SNAP25
6.434e-04-7.35PDZ_sfinterpro domainsIPR03603414941852149 LRRC7,PCLO,RIMS1,DLG4
6.444e-04-7.35acute_lymphoblastic_leukaemiaCOSMIC cancer mutationsacute_lymphoblastic_leukaemia2197151682847 DNM1,NRXN3,PCLO,PPFIA3,RASGRF1,SPTBN4,SYT1,CAMKV,L1CAM,PPFIA2,SLC8A3,CAMK2B,SLC4A10,CAMK2A,EPHA6
6.465e-04-7.34establishment of localization in cellbiological processGO:00516491619121820447 STX1A,PPFIA2,RYR2,LRRC7,PCLO,NRXN2,CPLX1,PPFIA3,SYT1,RIMS1,SNAP25,DNM1
6.621e-04-7.32calcium-mediated signalingbiological processGO:001972215441820447 GRIN1,CACNA1C,RYR2,GRIN2B
6.651e-04-7.32membrane organizationbiological processGO:006102476181820447 DLG4,STX1A,SPTBN4,NRXN2,CAMK2A,SNAP25,RIMS1,DNM1
6.682e-04-7.31cellular response to nitrogen compoundbiological processGO:190169958071820447 RYR2,GABRB2,HCN1,GRIN1,CACNA2D1,CACNA1A,CAMK2A
6.706e-04-7.31protein heterotetramerizationbiological processGO:00512901521820447 GRIN2B,GRIN1
6.706e-04-7.31establishment of protein localization to postsynaptic membranebiological processGO:19035401521820447 LRRC7,SNAP25
6.706e-04-7.31dense core granule localizationbiological processGO:00322531521820447 PPFIA2,SNAP25
6.706e-04-7.31neurotransmitter receptor transport to plasma membranebiological processGO:00988771521820447 SNAP25,LRRC7
6.894e-04-7.28ribbon synapsecellular componentGO:00974701521910850 SNAP25,DNM1
6.959e-04-7.27Axon guidanceKEGG pathwaysko043601745716130 EPHA6,CAMK2A,ABLIM1,CAMK2B,L1CAM
6.959e-04-7.27Axon guidanceKEGG pathwayshsa043601745716130 EPHA6,CAMK2A,ABLIM1,CAMK2B,L1CAM
6.963e-04-7.27-gene3d domains3.10.450.501221447048 CAMK2A,CAMK2B
7.043e-04-7.26NTF2-like_dom_sfinterpro domainsIPR0327101521852149 CAMK2B,CAMK2A
7.301e-04-7.22Common Pathways Underlying Drug AddictionWikiPathwaysWP2636423531023 CAMK2A,GRM5,GRIN1
7.592e-04-7.18SYT4 (synaptotagmin 4)protein interactions68601621945450 SYT1,STX1A
7.592e-04-7.18TAMALIN (trafficking regulator and scaffold protein tamalin)protein interactions1606221621945450 GRM5,DLG4
7.651e-04-7.18locomotory exploration behaviorbiological processGO:00356411621820447 DLG4,SLC4A10
7.651e-04-7.18regulation of short-term neuronal synaptic plasticitybiological processGO:00481721621820447 SLC4A10,PPFIA3
7.651e-04-7.18neuron cell-cell adhesionbiological processGO:00071581621820447 NRXN2,NRXN3
7.747e-04-7.16DLGAP4 (DLG associated protein 4)protein interactions228397031945450 DLG4,GRIN1,DLGAP2
7.866e-04-7.15node of Ranviercellular componentGO:00332681621910850 SCN8A,SPTBN4
8.136e-04-7.11cell junction assemblybiological processGO:003432928551820447 SPTBN2,NRXN2,PCLO,GABRB2,NRG3
8.152e-04-7.11peptide hormone secretionbiological processGO:00300727131820447 CPLX1,PCLO,STX1A
8.276e-04-7.10PH_DOMAINprosite domainsPS5000324651218637 RASGRF1,SPTBN2,MCF2L2,DNM1,SPTBN4
8.415e-04-7.08glutamate-gated receptor activitymolecular functionGO:00049701621809449 GRIN1,GRIN2B
8.590e-04-7.06KRTAP19-3 (keratin associated protein 19-3)protein interactions3379701721945450 CAMK2B,CAMK2A
8.590e-04-7.06GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C)protein interactions29051721945450 DLG4,GRIN1
8.657e-04-7.05synaptic vesicle membrane organizationbiological processGO:00484991721820447 SNAP25,STX1A
8.657e-04-7.05positive regulation of neurotransmitter secretionbiological processGO:00019561721820447 STX1A,SYT1
8.657e-04-7.05cell communication by electrical coupling involved in cardiac conductionbiological processGO:00860641721820447 RYR2,CACNA1C
8.664e-04-7.05CALM1 (calmodulin 1)protein interactions80160771945450 SYT1,CACNA1C,RYR2,IQSEC2,GRIN1,CAMK2B,GRM5
8.735e-04-7.04sodium ion transmembrane transporter activitymolecular functionGO:001508115841809449 SLC4A10,SCN8A,SLC8A3,HCN1
8.828e-04-7.03ErbB4 signaling eventsPathway Interaction DBerbb4_pathway323222614 GRIN2B,DLG4,NRG3
8.889e-04-7.03PDZprosite domainsPS5010614341218637 DLG4,RIMS1,PCLO,LRRC7
8.993e-04-7.01postsynaptic neurotransmitter receptor activitymolecular functionGO:00989607031809449 GRM5,GABRB2,GRIN2B
9.108e-04-7.00ADGRL1 (adhesion G protein-coupled receptor L1)protein interactions228597431945450 DLG4,CACNA1A,EDIL3
9.163e-04-7.00positive regulation of developmental growthbiological processGO:004863916841820447 SPTBN4,L1CAM,SYT1,RIMS1
9.198e-04-6.99PH-like_dom_sfinterpro domainsIPR01199343161852149 SPTBN2,DNM1,RASGRF1,MCF2L2,SPTBN4,IQSEC2
9.262e-04-6.98cell morphogenesis involved in neuron differentiationbiological processGO:004866744361820447 DLG4,SPTBN4,EPHA6,L1CAM,NRXN3,SNAP25
9.377e-04-6.97transport vesiclecellular componentGO:003013343761910850 DLG4,SYT1,SNAP25,STX1A,PPFIA2,GRIN1
9.561e-04-6.95peptide secretionbiological processGO:00027907531820447 STX1A,CPLX1,PCLO
9.575e-04-6.95regulation of calcium ion transmembrane transportbiological processGO:190316917041820447 RYR2,CACNA2D1,GRIN1,CACNA1C
9.723e-04-6.94secretory granule localizationbiological processGO:00322521821820447 PPFIA2,SNAP25
9.761e-04-6.93extracellular ligand-gated monoatomic ion channel activitymolecular functionGO:00052307231809449 GABRB2,GRIN1,GRIN2B
9.785e-04-6.93muscle system processbiological processGO:000301229751820447 SCN8A,CACNA1G,CACNA1C,CACNA2D1,RYR2
9.904e-04-6.92haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma74881682847 PCLO,RIMS1,CAMK2A,RYR2,LRRC7,GRIN2B,SPTBN4,CACNA1E
9.936e-04-6.91positive regulation of exocytosisbiological processGO:00459217631820447 SYT1,STX1A,VSNL1
1.017e-03-6.89Lig_chanpfam domainsPF000601821779547 GRIN2B,GRIN1
1.017e-03-6.89Lig_chan-Glu_bdpfam domainsPF106131821779547 GRIN1,GRIN2B
1.021e-03-6.89Iontro_rcpt_Cinterpro domainsIPR0013201821852149 GRIN1,GRIN2B
1.021e-03-6.89Iono_Glu_rcpt_metinterpro domainsIPR0015081821852149 GRIN1,GRIN2B
1.021e-03-6.89Glu/Gly-bdinterpro domainsIPR0195941821852149 GRIN2B,GRIN1
1.021e-03-6.89Ionotropic_Glu_rcptinterpro domainsIPR0156831821852149 GRIN1,GRIN2B
1.025e-03-6.88ovary-carcinoma-serous_carcinomaCOSMIC cancer mutationsovary-carcinoma-serous_carcinoma10710401682847 CCDC136,VSNL1,GRM5,NRG3,SLC8A3,GRIN2B,CELF3,SPTBN2,EDIL3,CACNA1C,SLC4A10,CAMK2B,PCLO,DLG4,RASGRF1,MCF2L2,RIMS1,CACNA1A,CACNA2D1,NRXN3,L1CAM,RYR2,CACNA1E,SYT1,NRXN2,FGF14,IQSEC2,CACNA1G,PPFIA2,EPHA6,CELF5,CAMK2A,DLGAP2,LRRC7,SCN8A,DNM1,MYT1L,HCN1,CAMKV,SPTBN4
1.036e-03-6.87sarcoplasmic reticulumcellular componentGO:00165297631910850 CAMK2B,CACNA2D1,RYR2
1.055e-03-6.85Nitric Oxide Signaling PathwaySMPDB pathwaysSMP00637779213698 GRIN1,DLG4
1.073e-03-6.84anatomical structure morphogenesisbiological processGO:00096532225141820447 NRXN3,RYR2,SPTBN2,CCDC136,HCN1,SLC4A10,L1CAM,EPHA6,ABLIM1,CACNA1C,SNAP25,NRG3,DLG4,SPTBN4
1.074e-03-6.84Cocaine addictionKEGG pathwaysko05030493716130 GRIN1,GRIN2B,DLG4
1.074e-03-6.84Cocaine addictionKEGG pathwayshsa05030493716130 GRIN2B,GRIN1,DLG4
1.077e-03-6.83CFAP263 (cilia and flagella associated protein 263)protein interactions290701921945450 PPFIA3,SPTBN2
1.077e-03-6.83ADRB1 (adrenoceptor beta 1)protein interactions1531921945450 DLG4,DLGAP2
1.077e-03-6.83DRD1 (dopamine receptor D1)protein interactions18121921945450 DLG4,GRIN1
1.101e-03-6.81VAMP2 (vesicle associated membrane protein 2)protein interactions684417741945450 STX1A,SNAP25,CPLX1,SYT1
1.115e-03-6.80parallel fiber to Purkinje cell synapsecellular componentGO:00986881921910850 SCN8A,SPTBN2
1.126e-03-6.79lobular_carcinomaCOSMIC cancer mutationslobular_carcinoma76381682847 RIMS1,PPFIA3,DLG4,CACNA1E,CAMK2B,CAMK2A,CAMKV,EPHA6
1.126e-03-6.79breast-carcinoma-lobular_carcinomaCOSMIC cancer mutationsbreast-carcinoma-lobular_carcinoma76381682847 EPHA6,CAMK2B,CACNA1E,CAMK2A,CAMKV,RIMS1,DLG4,PPFIA3
1.136e-03-6.78Cholinergic synapseKEGG pathwayshsa047251124716130 CAMK2A,CACNA1A,CACNA1C,CAMK2B
1.142e-03-6.78STX2 (syntaxin 2)protein interactions20548031945450 STX1A,SYT1,SNAP25
1.193e-03-6.73syntaxin-1 bindingmolecular functionGO:00170751921809449 SNAP25,SYT1
1.208e-03-6.72sodium ion transportbiological processGO:000681418141820447 SCN8A,SLC8A3,HCN1,SLC4A10
1.208e-03-6.72cellular processbiological processGO:000998714996461820447 CAMK2A,ABLIM1,L1CAM,EPHA6,CACNA1A,GRIN1,GABRB2,NRXN3,SLC8A3,CELF3,GRIN2B,SNAP25,PPFIA3,PPFIA2,CCDC136,CACNA1G,NRXN2,DLGAP2,FGF14,CACNA2D1,BRINP1,DLG4,DNM1,CACNA1C,RASGRF1,GRM5,IQSEC2,STX1A,HCN1,SPTBN2,LRRC7,SPTBN4,MYT1L,CELF5,EDIL3,SLC4A10,PCLO,CACNA1E,CAMK2B,RYR2,CPLX1,CAMKV,SCN8A,NRG3,SYT1,RIMS1
1.239e-03-6.69lower_thirdCOSMIC cancer mutationslower_third7961331682847 NRXN2,PPFIA2,CACNA1G,CELF5,CAMK2A,DLGAP2,LRRC7,GABRB2,EPHA6,SCN8A,PPFIA3,HCN1,SPTBN4,MYT1L,NRG3,GRIN2B,VSNL1,GRM5,SLC4A10,CACNA1C,CAMK2B,CELF3,SPTBN2,CACNA2D1,NRXN3,PCLO,GRIN1,RASGRF1,MCF2L2,RIMS1,CACNA1A,RYR2,CACNA1E
1.267e-03-6.67Innate Immune SystemREACTOME pathwaysR-HSA-1682491285121028537 SNAP25,GRIN1,NRG3,SPTBN4,DLG4,CAMK2B,LRRC7,SPTBN2,DNM1,RASGRF1,GRIN2B,CAMK2A
1.282e-03-6.66peptide transportbiological processGO:00158338331820447 STX1A,CPLX1,PCLO
1.282e-03-6.66positive regulation of calcium ion transmembrane transportbiological processGO:19044278331820447 RYR2,CACNA2D1,GRIN1
1.284e-03-6.66LGI-ADAM interactionsREACTOME pathwaysR-HSA-56829101521028537 STX1A,DLG4
1.294e-03-6.65ductolobular_carcinomaCOSMIC cancer mutationsductolobular_carcinoma1619121682847 RYR2,LRRC7,SPTBN2,NRXN3,SLC8A3,IQSEC2,FGF14,CACNA1G,MCF2L2,ABLIM1,CACNA1A,RIMS1
1.294e-03-6.65breast-carcinoma-ductolobular_carcinomaCOSMIC cancer mutationsbreast-carcinoma-ductolobular_carcinoma1619121682847 RIMS1,CACNA1A,MCF2L2,NRXN3,RYR2,ABLIM1,FGF14,IQSEC2,CACNA1G,SLC8A3,SPTBN2,LRRC7
1.301e-03-6.64positive regulation of transportbiological processGO:005105084481820447 SYT1,RYR2,SNAP25,CAMK2A,VSNL1,CACNA2D1,STX1A,GRIN1
1.309e-03-6.64vesicle localizationbiological processGO:005164818541820447 SNAP25,DNM1,PCLO,PPFIA2
1.315e-03-6.63RAB27A (RAB27A, member RAS oncogene family)protein interactions58738431945450 RIMS1,STX1A,SYT1
1.318e-03-6.63STXBP6 (syntaxin binding protein 6)protein interactions290912121945450 STX1A,SNAP25
1.328e-03-6.62regulation of receptor localization to synapsebiological processGO:19026832121820447 IQSEC2,CPLX1
1.329e-03-6.62regulation of multicellular organismal processbiological processGO:00512393113171820447 SLC8A3,CACNA2D1,DLG4,BRINP1,DLGAP2,SPTBN4,CACNA1C,RIMS1,GRIN2B,STX1A,GRIN1,GRM5,IQSEC2,L1CAM,RYR2,CACNA1G,CAMK2B
1.331e-03-6.62IQ_motif_EF-hand-BSinterpro domainsIPR0000488231852149 RASGRF1,SCN8A,IQSEC2
1.421e-03-6.56central nervous system neuron developmentbiological processGO:00219548631820447 SPTBN4,SLC4A10,BRINP1
1.447e-03-6.54CPLX2 (complexin 2)protein interactions108142221945450 STX1A,CPLX1
1.457e-03-6.534.1msmart domainsSM00294142971740 NRXN3,NRXN2
1.458e-03-6.53cell communication by electrical couplingbiological processGO:00106442221820447 RYR2,CACNA1C
1.458e-03-6.53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionbiological processGO:00108812221820447 CACNA1C,RYR2
1.464e-03-6.53femurCOSMIC cancer mutationsfemur1197101682847 HCN1,CACNA1E,DLGAP2,SYT1,LRRC7,NRXN3,NRG3,FGF14,PPFIA2,DLG4
1.478e-03-6.52-gene3d domains2.30.42.1014941447048 RIMS1,DLG4,PCLO,LRRC7
1.490e-03-6.51neuron projection morphogenesisbiological processGO:004881248661820447 DLG4,SNAP25,NRXN3,EPHA6,L1CAM,SPTBN4
1.497e-03-6.50SAM_DOMAINprosite domainsPS501057531218637 EPHA6,PPFIA2,PPFIA3
1.499e-03-6.50acute_myeloid_leukaemiaCOSMIC cancer mutationsacute_myeloid_leukaemia10418391682847 LRRC7,DLGAP2,CAMK2A,CELF5,EPHA6,CACNA1G,PPFIA2,IQSEC2,FGF14,NRXN2,ABLIM1,SPTBN4,HCN1,MYT1L,DNM1,PPFIA3,SCN8A,CAMK2B,CPLX1,CACNA1C,EDIL3,SLC4A10,SPTBN2,CELF3,GRIN2B,NRG3,GRM5,SYT1,CACNA1E,RYR2,NRXN3,CACNA2D1,CACNA1A,RIMS1,MCF2L2,RASGRF1,GRIN1,DLG4,PCLO
1.499e-03-6.50haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemiaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia10418391682847 SPTBN4,HCN1,MYT1L,DNM1,SCN8A,PPFIA3,LRRC7,DLGAP2,CAMK2A,CELF5,EPHA6,PPFIA2,CACNA1G,IQSEC2,FGF14,NRXN2,ABLIM1,SYT1,CACNA1E,RYR2,NRXN3,CACNA2D1,RIMS1,CACNA1A,RASGRF1,GRIN1,MCF2L2,DLG4,PCLO,CAMK2B,CPLX1,EDIL3,SLC4A10,CACNA1C,SPTBN2,CELF3,GRIN2B,NRG3,GRM5
1.503e-03-6.50NLGN3 (neuroligin 3)protein interactions544138831945450 NRXN2,NRXN3,DLG4
1.570e-03-6.46plasma membrane bounded cell projection morphogenesisbiological processGO:012003949161820447 SNAP25,NRXN3,DLG4,L1CAM,EPHA6,SPTBN4
1.578e-03-6.45cervix-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationscervix-carcinoma-squamous_cell_carcinoma11789421682847 DNM1,SCN8A,PPFIA3,HCN1,SPTBN4,MYT1L,NRXN2,PPFIA2,CACNA1G,FGF14,IQSEC2,ABLIM1,CAMK2A,CELF5,LRRC7,GABRB2,DLGAP2,EPHA6,CACNA2D1,NRXN3,RASGRF1,MCF2L2,DLG4,GRIN1,PCLO,RIMS1,CACNA1A,RYR2,SYT1,CACNA1E,L1CAM,SLC8A3,NRG3,GRIN2B,GRM5,SLC4A10,CACNA1C,EDIL3,CAMK2B,CPLX1,CELF3,SPTBN2
1.582e-03-6.45TSPOAP1 (TSPO associated protein 1)protein interactions92562321945450 CACNA1A,DLGAP2
1.595e-03-6.44ionotropic glutamate receptor signaling pathwaybiological processGO:00352352321820447 GRIN2B,GRIN1
1.595e-03-6.44regulation of vesicle fusionbiological processGO:00313382321820447 SYT1,CPLX1
1.595e-03-6.44positive regulation of neurotransmitter transportbiological processGO:00515902321820447 STX1A,SYT1
1.595e-03-6.44cervixCOSMIC cancer mutationscervix11793421682847 GRM5,SLC8A3,NRG3,GRIN2B,CELF3,SPTBN2,EDIL3,SLC4A10,CACNA1C,CAMK2B,CPLX1,DLG4,GRIN1,MCF2L2,RASGRF1,PCLO,RIMS1,CACNA1A,CACNA2D1,NRXN3,L1CAM,RYR2,SYT1,CACNA1E,ABLIM1,NRXN2,CACNA1G,PPFIA2,FGF14,IQSEC2,EPHA6,CAMK2A,CELF5,GABRB2,LRRC7,DLGAP2,SCN8A,PPFIA3,DNM1,MYT1L,HCN1,SPTBN4
1.653e-03-6.41cell projection morphogenesisbiological processGO:004885849661820447 L1CAM,EPHA6,SPTBN4,SNAP25,NRXN3,DLG4
1.674e-03-6.39Actinin_actin-bd_CSinterpro domainsIPR0015892321852149 SPTBN2,SPTBN4
1.712e-03-6.37vesicle organizationbiological processGO:001605033751820447 DNM1,CCDC136,DLG4,SNAP25,STX1A
1.723e-03-6.36CNKSR2 (connector enhancer of kinase suppressor of Ras 2)protein interactions228662421945450 DLG4,LRRC7
1.724e-03-6.36hormone secretionbiological processGO:00468799231820447 PCLO,CPLX1,STX1A
1.728e-03-6.36regulation of cell projection organizationbiological processGO:003134468371820447 PPFIA2,L1CAM,DLG4,GRIN2B,CAMK2B,SNAP25,LRRC7
1.737e-03-6.36positive regulation of dendrite extensionbiological processGO:19038612421820447 SYT1,RIMS1
1.737e-03-6.36neurotransmitter receptor transportbiological processGO:00996372421820447 SNAP25,LRRC7
1.753e-03-6.35voltage-gated sodium channel activitymolecular functionGO:00052482321809449 HCN1,SCN8A
1.800e-03-6.32amyloid-beta bindingmolecular functionGO:00015408931809449 CACNA1A,GRIN1,GRIN2B
1.816e-03-6.31Spectrinpfam domainsPF004352421779547 SPTBN2,SPTBN4
1.817e-03-6.31TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1)protein interactions854619431945450 GRIN2B,DLG4,CAMK2A
1.823e-03-6.31Spectrin_repeatinterpro domainsIPR0020172421852149 SPTBN4,SPTBN2
1.852e-03-6.29SAMinterpro domainsIPR0016609231852149 PPFIA2,PPFIA3,EPHA6
1.854e-03-6.29Schaffer collateral - CA1 synapsecellular componentGO:00986859331910850 CPLX1,IQSEC2,GRM5
1.868e-03-6.28IQprosite domainsPS500968131218637 RASGRF1,IQSEC2,SCN8A
1.870e-03-6.28PPFIA2 (PTPRF interacting protein alpha 2)protein interactions84992521945450 PPFIA2,PPFIA3
1.870e-03-6.28SLC6A3 (solute carrier family 6 member 3)protein interactions65312521945450 STX1A,CAMK2A
1.884e-03-6.27GnRH Signaling PathwaySMPDB pathwaysSMP006381147313698 CAMK2A,LRRC7,CACNA1C
1.885e-03-6.27presynapse organizationbiological processGO:00991722521820447 PCLO,PPFIA2
1.913e-03-6.26human chr14q24.3-q31.1chromosome locationhuman chr14q24.3-q31.1112613450 NRXN3
1.913e-03-6.26human chr11q14.2-q14.3chromosome locationhuman chr11q14.2-q14.3112613450 GRM5
1.929e-03-6.25HOMER1 (homer scaffold protein 1)protein interactions94569631945450 RYR2,SPTBN4,GRM5
1.944e-03-6.24endocytic vesicle membranecellular componentGO:003066620341910850 CAMK2A,CAMK2B,SYT1,DLG4
2.023e-03-6.20PDE4A (phosphodiesterase 4A)protein interactions51412621945450 CAMK2B,CAMK2A
2.047e-03-6.19KRTAP19-5 (keratin associated protein 19-5)protein interactions3379729831945450 CAMK2A,CELF5,CAMK2B
2.052e-03-6.19NMDARECEPTORprints domainsPR00177182522720 GRIN1,GRIN2B
2.082e-03-6.17cellular localizationbiological processGO:00516412660151820447 STX1A,HCN1,PPFIA2,RYR2,LRRC7,PCLO,DLG4,NRXN2,CPLX1,SPTBN4,SYT1,SNAP25,RIMS1,PPFIA3,DNM1
2.118e-03-6.16serous_carcinomaCOSMIC cancer mutationsserous_carcinoma10987401682847 CACNA1E,SYT1,RYR2,L1CAM,CACNA2D1,NRXN3,CACNA1A,RIMS1,PCLO,RASGRF1,MCF2L2,DLG4,CAMK2B,SLC4A10,CACNA1C,EDIL3,SPTBN2,CELF3,GRIN2B,NRG3,SLC8A3,VSNL1,GRM5,CCDC136,SPTBN4,HCN1,CAMKV,MYT1L,DNM1,SCN8A,DLGAP2,LRRC7,CELF5,CAMK2A,EPHA6,FGF14,IQSEC2,PPFIA2,CACNA1G,NRXN2
2.127e-03-6.15regulation of striated muscle contractionbiological processGO:00069429931820447 CACNA1C,SLC8A3,RYR2
2.133e-03-6.15endocytic vesiclecellular componentGO:003013934951910850 CAMK2B,SYT1,DLG4,CAMK2A,DNM1
2.155e-03-6.14ovaryCOSMIC cancer mutationsovary14770471682847 ABLIM1,CACNA1G,CELF5,DLGAP2,PPFIA3,CAMKV,SPTBN4,VSNL1,GRM5,NRG3,GRIN2B,PCLO,RASGRF1,RIMS1,CACNA1A,NRXN3,RYR2,CACNA1E,NRXN2,IQSEC2,FGF14,PPFIA2,EPHA6,CAMK2A,STX1A,GABRB2,LRRC7,SCN8A,DNM1,MYT1L,HCN1,SNAP25,CCDC136,SLC8A3,CELF3,SPTBN2,SLC4A10,EDIL3,CACNA1C,CPLX1,CAMK2B,MCF2L2,DLG4,GRIN1,CACNA2D1,L1CAM,SYT1
2.155e-03-6.14positive regulation of monoatomic ion transportbiological processGO:004327021241820447 CAMK2A,RYR2,CACNA2D1,GRIN1
2.168e-03-6.13APBA1 (amyloid beta precursor protein binding family A member 1)protein interactions32010031945450 DLG4,ABLIM1,STX1A
2.170e-03-6.13DCAF6 (DDB1 and CUL4 associated factor 6)protein interactions5582721341945450 CAMK2B,DLG4,GRIN1,DNM1
2.180e-03-6.13ACTININ_2prosite domainsPS000202321218637 SPTBN4,SPTBN2
2.180e-03-6.13ACTININ_1prosite domainsPS000192321218637 SPTBN4,SPTBN2
2.181e-03-6.13KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)protein interactions37682721945450 DLG4,ABLIM1
2.181e-03-6.13DLGAP1 (DLG associated protein 1)protein interactions92292721945450 DLG4,DLGAP2
2.198e-03-6.12regulation of dendrite extensionbiological processGO:19038592721820447 SYT1,RIMS1
2.198e-03-6.12regulation of cardiac muscle contraction by calcium ion signalingbiological processGO:00108822721820447 RYR2,CACNA1C
2.198e-03-6.12positive regulation of protein tyrosine kinase activitybiological processGO:00610982721820447 GRM5,DLG4
2.207e-03-6.12DLG1 (discs large MAGUK scaffold protein 1)protein interactions173921441945450 DLGAP2,GRIN1,GRIN2B,CAMK2A
2.230e-03-6.11regulation of monoatomic ion transmembrane transporter activitybiological processGO:003241221441820447 CACNA2D1,RYR2,DLG4,FGF14
2.230e-03-6.11PRKCG (protein kinase C gamma)protein interactions558210131945450 GRM5,GRIN1,GRIN2B
2.259e-03-6.09axonal growth conecellular componentGO:00442952721910850 L1CAM,SNAP25
2.289e-03-6.08calcium ion bindingmolecular functionGO:000550968371809449 PCLO,SYT1,RYR2,VSNL1,EDIL3,CACNA1E,GRIN1
2.307e-03-6.07T_SNARE_dominterpro domainsIPR0007272721852149 SNAP25,STX1A
2.315e-03-6.07ovary-carcinoma-clear_cell_carcinomaCOSMIC cancer mutationsovary-carcinoma-clear_cell_carcinoma66571682847 CAMK2A,CAMKV,CELF5,LRRC7,CAMK2B,EPHA6,MCF2L2
2.363e-03-6.05dendritic spine developmentbiological processGO:00609962821820447 DLG4,CAMK2A
2.363e-03-6.05regulation of cardiac conductionbiological processGO:19037792821820447 SLC8A3,RYR2
2.363e-03-6.05regulation of calcium ion-dependent exocytosisbiological processGO:00171582821820447 SYT1,STX1A
2.381e-03-6.04hormone transportbiological processGO:000991410331820447 CPLX1,PCLO,STX1A
2.395e-03-6.03clear_cell_carcinomaCOSMIC cancer mutationsclear_cell_carcinoma66971682847 LRRC7,CAMK2B,CELF5,CAMKV,CAMK2A,EPHA6,MCF2L2
2.422e-03-6.02plasma membrane bounded cell projection organizationbiological processGO:0120036115291820447 RASGRF1,NRXN3,SNAP25,DLG4,SPTBN4,EPHA6,L1CAM,CAMK2A,ABLIM1
2.425e-03-6.02PBPesmart domainsSM00079182971740 GRIN1,GRIN2B
2.425e-03-6.02Lig_chan-Glu_bdsmart domainsSM00918182971740 GRIN1,GRIN2B
2.452e-03-6.01axonogenesisbiological processGO:000740936651820447 SNAP25,NRXN3,L1CAM,EPHA6,SPTBN4
2.514e-03-5.99CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2)protein interactions103692921945450 GRIN1,DLG4
2.515e-03-5.99regulation of postsynapse organizationbiological processGO:009917510531820447 CAMK2B,GRIN2B,PPFIA2
2.534e-03-5.98regulation of cardiac muscle cell action potentialbiological processGO:00989012921820447 RYR2,CACNA1C
2.534e-03-5.98postsynaptic membrane organizationbiological processGO:00019412921820447 DLG4,NRXN2
2.547e-03-5.97regulation of transmembrane transporter activitybiological processGO:002289822241820447 CACNA2D1,RYR2,DLG4,FGF14
2.569e-03-5.96vesiclecellular componentGO:00319824141201910850 CAMK2B,LRRC7,GABRB2,SYT1,CCDC136,PPFIA2,GRIN2B,GRIN1,CAMKV,CACNA2D1,STX1A,SNAP25,EDIL3,CAMK2A,SCN8A,DLG4,PCLO,PPFIA3,SPTBN4,DNM1
2.570e-03-5.96Cript (CXXC repeat containing interactor of PDZ3 domain)protein interactions56725111945450 DLG4
2.570e-03-5.96Epha3 (Eph receptor A3)protein interactions13837111945450 L1CAM
2.570e-03-5.96Septin1 (Septin 1)protein interactions33114111945450 STX1A
2.570e-03-5.96Kcna4 (potassium voltage-gated channel subfamily A member 4)protein interactions25469111945450 DLG4
2.570e-03-5.96Ank3 (ankyrin 3)protein interactions361833111945450 L1CAM
2.570e-03-5.96pnut (peanut)protein interactions35801111945450 STX1A
2.570e-03-5.96HEM15 (ferrochelatase HEM15)protein interactions854347111945450 CAMK2B
2.570e-03-5.96Epha7 (Eph receptor A7)protein interactions171287111945450 L1CAM
2.570e-03-5.96Vps16 (VPS16 core subunit of CORVET and HOPS complexes)protein interactions296159111945450 STX1A
2.570e-03-5.96Vps18 (VPS18 core subunit of CORVET and HOPS complexes)protein interactions296083111945450 STX1A
2.570e-03-5.96SEC9 (Sec9p)protein interactions852892111945450 STX1A
2.570e-03-5.96SLA1 (cytoskeletal protein-binding protein SLA1)protein interactions852276111945450 DNM1
2.570e-03-5.96EPHB2 (EPH receptor B2)protein interactions396513111945450 L1CAM
2.570e-03-5.96Vps11 (VPS11 core subunit of CORVET and HOPS complexes)protein interactions315600111945450 STX1A
2.570e-03-5.96Shank1 (SH3 and multiple ankyrin repeat domains 1)protein interactions78957111945450 DLG4
2.570e-03-5.96Ephb1 (Eph receptor B1)protein interactions270190111945450 L1CAM
2.570e-03-5.96SNC1 (SNAP receptor SNC1)protein interactions851203111945450 STX1A
2.570e-03-5.96Rnf138 (ring finger protein 138)protein interactions94196111945450 CACNA1A
2.570e-03-5.96EPHA4 (EPH receptor A4)protein interactions395559111945450 L1CAM
2.570e-03-5.96Ephb3 (Eph receptor B3)protein interactions13845111945450 L1CAM
2.575e-03-5.96T_SNAREprosite domainsPS501922521218637 STX1A,SNAP25
2.582e-03-5.96chemorepulsion involved in interneuron migration from the subpallium to the cortexbiological processGO:0021842111820447 NRG3
2.582e-03-5.96peptidyl-threonine autophosphorylationbiological processGO:1990443111820447 CAMK2A
2.582e-03-5.96regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membranebiological processGO:0099145111820447 CPLX1
2.582e-03-5.96fast, calcium ion-dependent exocytosis of neurotransmitterbiological processGO:0098746111820447 SYT1
2.582e-03-5.96propylene metabolic processbiological processGO:0018964111820447 GRIN1
2.582e-03-5.96positive regulation of calcium ion-dependent exocytosis of neurotransmitterbiological processGO:1903235111820447 SYT1
2.582e-03-5.96directional guidance of interneurons involved in migration from the subpallium to the cortexbiological processGO:0021840111820447 NRG3
2.582e-03-5.96clathrin coat assembly involved in endocytosisbiological processGO:0099049111820447 DNM1
2.582e-03-5.96synchronous neurotransmitter secretionbiological processGO:0071911111820447 SYT1
2.608e-03-5.95Periplasmic binding protein-like IIgene3d domains3.40.190.102321447048 GRIN1,GRIN2B
2.617e-03-5.95postsynaptic spectrin-associated cytoskeletoncellular componentGO:0099189111910850 SPTBN2
2.617e-03-5.95epididymosomecellular componentGO:0098875111910850 PPFIA3
2.646e-03-5.93VDCC_L_a1csuinterpro domainsIPR005451111852149 CACNA1C
2.646e-03-5.93SRRM3_cwf21interpro domainsIPR047489111852149 SRRM3
2.646e-03-5.93EPH-A6_SAMinterpro domainsIPR042746111852149 EPHA6
2.646e-03-5.93Na_channel_a8suinterpro domainsIPR008054111852149 SCN8A
2.646e-03-5.93PCLO_FYVE1interpro domainsIPR042720111852149 PCLO
2.646e-03-5.93GPCR_3_mGluR5interpro domainsIPR000202111852149 GRM5
2.646e-03-5.93SNAP-25_N_SNARE_chordinterpro domainsIPR039077111852149 SNAP25
2.646e-03-5.93EphA6_rcpt_lig-bdinterpro domainsIPR034280111852149 EPHA6
2.646e-03-5.93TMEM266interpro domainsIPR042857111852149 TMEM266
2.646e-03-5.93CACNA1Ainterpro domainsIPR005448111852149 CACNA1A
2.646e-03-5.93VDCC_R_a1suinterpro domainsIPR005449111852149 CACNA1E
2.690e-03-5.92UBTFL1 (upstream binding transcription factor like 1)protein interactions6426233021945450 CCDC136,STX1A
2.690e-03-5.92GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B)protein interactions1164443021945450 DLG4,GRIN1
2.708e-03-5.91structural constituent of presynapsemolecular functionGO:0099181111809449 PPFIA2
2.708e-03-5.91monoatomic ion antiporter activity involved in regulation of postsynaptic membrane potentialmolecular functionGO:0099580111809449 SLC8A3
2.708e-03-5.91P2Y1 nucleotide receptor bindingmolecular functionGO:0031812111809449 DLG4
2.708e-03-5.91G protein-coupled nucleotide receptor bindingmolecular functionGO:0031811111809449 DLG4
2.708e-03-5.91intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potentialmolecular functionGO:0140232111809449 HCN1
2.708e-03-5.91voltage-gated calcium channel activity involved in bundle of His cell action potentialmolecular functionGO:0086057111809449 CACNA2D1
2.710e-03-5.91neuronal action potentialbiological processGO:00192283021820447 SCN8A,HCN1
2.725e-03-5.91PDZsmart domainsSM002281434971740 LRRC7,RIMS1,DLG4,PCLO
2.796e-03-5.88postsynapse organizationbiological processGO:009917310931820447 DLG4,SPTBN2,NRXN2
2.830e-03-5.87EGF_3prosite domainsPS5002619641218637 NRXN2,NRG3,NRXN3,EDIL3
2.870e-03-5.85Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)gene3d domains2.30.29.3043161447048 SPTBN4,IQSEC2,MCF2L2,DNM1,SPTBN2,RASGRF1
2.870e-03-5.85GRM5 (glutamate metabotropic receptor 5)protein interactions29153121945450 GRIN1,GRM5
2.892e-03-5.85positive regulation of calcium ion transmembrane transporter activitybiological processGO:19010213121820447 CACNA2D1,RYR2
2.892e-03-5.85regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumbiological processGO:00108803121820447 RYR2,CACNA1C
2.922e-03-5.84cell differentiationbiological processGO:00301543645181820447 CAMK2B,CCDC136,NRXN3,EPHA6,L1CAM,CAMK2A,HCN1,GABRB2,SLC4A10,RASGRF1,SNAP25,RIMS1,SYT1,SPTBN4,MYT1L,DLG4,BRINP1,SLC8A3
2.939e-03-5.83calcium ion homeostasisbiological processGO:005507423141820447 GRIN1,RYR2,SLC8A3,GRM5
2.950e-03-5.83cellular developmental processbiological processGO:00488693648181820447 SLC4A10,HCN1,GABRB2,CAMK2A,EPHA6,L1CAM,NRXN3,CCDC136,CAMK2B,SLC8A3,DLG4,BRINP1,MYT1L,SPTBN4,SYT1,RIMS1,SNAP25,RASGRF1
3.038e-03-5.80HSF1-dependent transactivationREACTOME pathwaysR-HSA-33715712321028537 CAMK2B,CAMK2A
3.046e-03-5.79PRKCB (protein kinase C beta)protein interactions557923441945450 GRIN1,GRIN2B,GRM5,GABRB2
3.074e-03-5.78Brain-Derived Neurotrophic Factor (BDNF) signaling pathwayWikiPathwaysWP23801444531023 GRIN2B,CAMK2A,RASGRF1,GRIN1
3.080e-03-5.78ligand-gated ion channel signaling pathwaybiological processGO:19908063221820447 GRIN2B,GRIN1
3.177e-03-5.75intracellularly ligand-gated monoatomic ion channel activitymolecular functionGO:00052173121809449 RYR2,HCN1
3.191e-03-5.75cell projection organizationbiological processGO:0030030120091820447 RASGRF1,NRXN3,SNAP25,DLG4,SPTBN4,EPHA6,L1CAM,ABLIM1,CAMK2A
3.202e-03-5.74skin-head_neck-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsskin-head_neck-carcinoma-squamous_cell_carcinoma14191461682847 CACNA1G,ABLIM1,CELF5,DLGAP2,PPFIA3,CAMKV,SPTBN4,NRG3,GRIN2B,GRM5,VSNL1,NRXN3,RASGRF1,PCLO,CACNA1A,RIMS1,RYR2,CACNA1E,NRXN2,PPFIA2,FGF14,IQSEC2,CAMK2A,GABRB2,LRRC7,EPHA6,DNM1,SCN8A,HCN1,SNAP25,MYT1L,SLC8A3,CCDC136,EDIL3,CACNA1C,SLC4A10,CAMK2B,CPLX1,CELF3,SPTBN2,CACNA2D1,GRIN1,MCF2L2,DLG4,SYT1,L1CAM
3.249e-03-5.73ADGRB1 (adhesion G protein-coupled receptor B1)protein interactions5753321945450 LRRC7,DLG4
3.257e-03-5.73Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGG pathwayshsa05412723716130 CACNA2D1,CACNA1C,RYR2
3.257e-03-5.73Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGG pathwaysko05412723716130 RYR2,CACNA2D1,CACNA1C
3.269e-03-5.72EGF-like_dominterpro domainsIPR00074223241852149 EDIL3,NRXN3,NRG3,NRXN2
3.271e-03-5.72protein localization to cell peripherybiological processGO:199077823841820447 SNAP25,LRRC7,DLG4,SPTBN4
3.305e-03-5.71Metipranolol Action PathwaySMPDB pathwaysSMP000066757313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Amlodipine Action PathwaySMPDB pathwaysSMP000037657313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Bopindolol Action PathwaySMPDB pathwaysSMP000065757313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Muscle/Heart ContractionSMPDB pathwaysSMP000058857313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Nimodipine Action PathwaySMPDB pathwaysSMP000038057313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Disopyramide Action PathwaySMPDB pathwaysSMP000032557313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Propranolol Action PathwaySMPDB pathwaysSMP000030757313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Ibutilide Action PathwaySMPDB pathwaysSMP000033257313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Flecainide Action PathwaySMPDB pathwaysSMP000033157313698 CACNA1C,CACNA1G,RYR2
3.305e-03-5.71Arbutamine Action PathwaySMPDB pathwaysSMP000066457313698 CACNA1C,CACNA1G,RYR2
3.305e-03-5.71Verapamil Action PathwaySMPDB pathwaysSMP000037557313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Oxprenolol Action PathwaySMPDB pathwaysSMP000030457313698 CACNA1C,CACNA1G,RYR2
3.305e-03-5.71Practolol Action PathwaySMPDB pathwaysSMP000066957313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Timolol Action PathwaySMPDB pathwaysSMP000065957313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Fosphenytoin (Antiarrhythmic) Action PathwaySMPDB pathwaysSMP000032657313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Nifedipine Action PathwaySMPDB pathwaysSMP000037957313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Penbutolol Action PathwaySMPDB pathwaysSMP000030557313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Metoprolol Action PathwaySMPDB pathwaysSMP000030257313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Bupranolol Action PathwaySMPDB pathwaysSMP000067057313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Esmolol Action PathwaySMPDB pathwaysSMP000030157313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Epinephrine Action PathwaySMPDB pathwaysSMP000066157313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Atenolol Action PathwaySMPDB pathwaysSMP000029857313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Amiodarone Action PathwaySMPDB pathwaysSMP000066557313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Dobutamine Action PathwaySMPDB pathwaysSMP000066257313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Procainamide (Antiarrhythmic) Action PathwaySMPDB pathwaysSMP000032457313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Pindolol Action PathwaySMPDB pathwaysSMP000030657313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Felodipine Action PathwaySMPDB pathwaysSMP000037757313698 CACNA1C,CACNA1G,RYR2
3.305e-03-5.71Levobunolol Action PathwaySMPDB pathwaysSMP000066657313698 CACNA1C,CACNA1G,RYR2
3.305e-03-5.71Mexiletine Action PathwaySMPDB pathwaysSMP000032957313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Sotalol Action PathwaySMPDB pathwaysSMP000066057313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Isradipine Action PathwaySMPDB pathwaysSMP000037857313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Diltiazem Action PathwaySMPDB pathwaysSMP000035957313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Betaxolol Action PathwaySMPDB pathwaysSMP000029957313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Bisoprolol Action PathwaySMPDB pathwaysSMP000030057313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Alprenolol Action PathwaySMPDB pathwaysSMP000029757313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Quinidine Action PathwaySMPDB pathwaysSMP000032357313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Nisoldipine Action PathwaySMPDB pathwaysSMP000038157313698 CACNA1C,CACNA1G,RYR2
3.305e-03-5.71Nebivolol Action PathwaySMPDB pathwaysSMP000036657313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Nitrendipine Action PathwaySMPDB pathwaysSMP000038257313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Acebutolol Action PathwaySMPDB pathwaysSMP000029657313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Nadolol Action PathwaySMPDB pathwaysSMP000030357313698 RYR2,CACNA1G,CACNA1C
3.305e-03-5.71Isoprenaline Action PathwaySMPDB pathwaysSMP000066357313698 CACNA1G,RYR2,CACNA1C
3.305e-03-5.71Carteolol Action PathwaySMPDB pathwaysSMP000065857313698 CACNA1C,CACNA1G,RYR2
3.305e-03-5.71Tocainide Action PathwaySMPDB pathwaysSMP000033057313698 CACNA1C,RYR2,CACNA1G
3.305e-03-5.71Bevantolol Action PathwaySMPDB pathwaysSMP000066857313698 CACNA1C,CACNA1G,RYR2
3.383e-03-5.69ETS1 (ETS proto-oncogene 1, transcription factor)protein interactions211311731945450 CAMK2B,SPTBN4,CAMK2A
3.383e-03-5.69protein tyrosine kinase activator activitymolecular functionGO:00302963221809449 GRM5,NRG3
3.446e-03-5.67SHANK2 (SH3 and multiple ankyrin repeat domains 2)protein interactions229413421945450 DLGAP2,DLG4
3.465e-03-5.67DNM1 (dynamin 1)protein interactions175911831945450 GRIN1,SNAP25,DNM1
3.473e-03-5.66vesicle docking involved in exocytosisbiological processGO:00069043421820447 SNAP25,PPFIA3
3.476e-03-5.66Labetalol Action PathwaySMPDB pathwaysSMP000036858313698 RYR2,CACNA1G,CACNA1C
3.476e-03-5.66Carvedilol Action PathwaySMPDB pathwaysSMP000036758313698 CACNA1C,RYR2,CACNA1G
3.520e-03-5.65Cardiac muscle contractionKEGG pathwayshsa04260743716130 RYR2,CACNA1C,CACNA2D1
3.520e-03-5.65Cardiac muscle contractionKEGG pathwaysko04260743716130 RYR2,CACNA1C,CACNA2D1
3.623e-03-5.62t_SNAREsmart domainsSM00397222971740 STX1A,SNAP25
3.638e-03-5.62central nervous system developmentbiological processGO:000741799581820447 GRIN2B,SPTBN2,NRG3,SPTBN4,BRINP1,SLC4A10,GRIN1,SLC8A3
3.649e-03-5.61ABRA (actin binding Rho activating protein)protein interactions1377353521945450 ABLIM1,SPTBN2
3.652e-03-5.61Lidocaine (Antiarrhythmic) Action PathwaySMPDB pathwaysSMP000032859313698 CACNA1C,RYR2,CACNA1G
3.676e-03-5.61haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemiaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia2081131682847 SLC8A3,SLC4A10,CAMK2A,CAMK2B,EPHA6,DNM1,PCLO,PPFIA3,RASGRF1,CAMKV,SPTBN4,SYT1,L1CAM
3.677e-03-5.61actin filament cappingbiological processGO:00516933521820447 SPTBN4,SPTBN2
3.677e-03-5.61regulation of cardiac muscle cell contractionbiological processGO:00860043521820447 RYR2,CACNA1C
3.681e-03-5.60regulation of cell morphogenesisbiological processGO:002260424641820447 DLG4,SYT1,RIMS1,CAMK2B
3.826e-03-5.57PQVDCCALPHA1prints domainsPR0163211522720 CACNA1A
3.826e-03-5.57RVDCCALPHA1prints domainsPR0163311522720 CACNA1E
3.826e-03-5.57NACHANNEL8prints domainsPR0166711522720 SCN8A
3.826e-03-5.57LVDCCALPHA1Cprints domainsPR0163511522720 CACNA1C
3.826e-03-5.57MTABOTROPC5Rprints domainsPR0105511522720 GRM5
3.843e-03-5.56regulation of muscle system processbiological processGO:009025724941820447 CACNA1C,SLC8A3,RYR2,CAMK2B
3.857e-03-5.56RAB33A (RAB33A, member RAS oncogene family)protein interactions93633621945450 CCDC136,SYT1
3.857e-03-5.56SCN5A (sodium voltage-gated channel alpha subunit 5)protein interactions63313621945450 DLG4,FGF14
3.893e-03-5.55PTPRD (protein tyrosine phosphatase receptor type D)protein interactions578912331945450 PPFIA3,PPFIA2,ABLIM1
3.934e-03-5.54SAM/pointed_sfinterpro domainsIPR01376112031852149 EPHA6,PPFIA3,PPFIA2
4.062e-03-5.51Arrhythmogenic Right Ventricular CardiomyopathyWikiPathwaysWP2118763531023 RYR2,CACNA1C,CACNA2D1
4.062e-03-5.51Laminin_G_2pfam domainsPF022103621779547 NRXN3,NRXN2
4.067e-03-5.50regulation of transporter activitybiological processGO:003240925341820447 CACNA2D1,RYR2,DLG4,FGF14
4.161e-03-5.48haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemiaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia73971682847 PCLO,RASGRF1,CACNA1A,SPTBN2,RYR2,CAMKV,HCN1
4.161e-03-5.48acute_lymphoblastic_T_cell_leukaemiaCOSMIC cancer mutationsacute_lymphoblastic_T_cell_leukaemia73971682847 CAMKV,HCN1,RYR2,RASGRF1,PCLO,SPTBN2,CACNA1A
4.187e-03-5.48C2pfam domainsPF0016812331779547 RIMS1,PCLO,SYT1
4.209e-03-5.47cytoplasmic vesicle membranecellular componentGO:0030659123091910850 GABRB2,SYT1,DLG4,CAMK2B,CCDC136,CAMK2A,STX1A,CAMKV,SNAP25
4.241e-03-5.46positive regulation of growthbiological processGO:004592725641820447 SPTBN4,L1CAM,SYT1,RIMS1
4.287e-03-5.45SAM_2pfam domainsPF076473721779547 PPFIA3,PPFIA2
4.290e-03-5.45ZNF440 (zinc finger protein 440)protein interactions1260703821945450 CCDC136,STX1A
4.290e-03-5.45AOC3 (amine oxidase copper containing 3)protein interactions86393821945450 CAMK2A,STX1A
4.303e-03-5.45lung-left_upper_lobe-carcinoma-adenocarcinomaCOSMIC cancer mutationslung-left_upper_lobe-carcinoma-adenocarcinoma55661682847 CACNA1A,CCDC136,PCLO,CACNA1E,RYR2,CACNA2D1
4.323e-03-5.44mRNA splice site recognitionbiological processGO:00063763821820447 CELF3,CELF5
4.328e-03-5.44blood circulationbiological processGO:000801541851820447 CACNA1C,CACNA1G,CACNA2D1,RYR2,SCN8A
4.352e-03-5.44CDCA8 (cell division cycle associated 8)protein interactions5514312831945450 CAMK2A,SYT1,VSNL1
4.379e-03-5.43left_upper_lobeCOSMIC cancer mutationsleft_upper_lobe55861682847 PCLO,CCDC136,CACNA1A,CACNA2D1,RYR2,CACNA1E
4.416e-03-5.42axon developmentbiological processGO:006156442051820447 SPTBN4,L1CAM,EPHA6,NRXN3,SNAP25
4.442e-03-5.42dense core granulecellular componentGO:00310453821910850 CACNA2D1,SYT1
4.488e-03-5.41Phase 2 - plateau phaseREACTOME pathwaysR-HSA-55768932821028537 CACNA1C,CACNA2D1
4.488e-03-5.41Recycling pathway of L1REACTOME pathwaysR-HSA-4372392821028537 L1CAM,DNM1
4.504e-03-5.40SNAP receptor activitymolecular functionGO:00054843721809449 SNAP25,STX1A
4.506e-03-5.40upper_aerodigestive_tractCOSMIC cancer mutationsupper_aerodigestive_tract13181441682847 PPFIA3,SCN8A,DNM1,MYT1L,CAMKV,HCN1,SPTBN4,SNAP25,ABLIM1,NRXN2,CACNA1G,PPFIA2,IQSEC2,EPHA6,CAMK2A,CELF5,STX1A,LRRC7,GABRB2,DLGAP2,RASGRF1,GRIN1,MCF2L2,DLG4,PCLO,RIMS1,CACNA1A,NRXN3,CACNA2D1,L1CAM,RYR2,SYT1,CACNA1E,CCDC136,GRM5,SLC8A3,NRG3,GRIN2B,CELF3,SPTBN2,EDIL3,SLC4A10,CACNA1C,CAMK2B
4.515e-03-5.40E (envelope protein)protein interactions142545993921945450 RIMS1,LRRC7
4.549e-03-5.39long-term memorybiological processGO:00076163921820447 SNAP25,RASGRF1
4.549e-03-5.39negative regulation of actin filament depolymerizationbiological processGO:00308353921820447 SPTBN4,SPTBN2
4.643e-03-5.37myelodysplastic_syndromeCOSMIC cancer mutationsmyelodysplastic_syndrome117491682847 GRIN2B,NRG3,GRM5,RIMS1,CAMK2B,HCN1,CAMK2A,CAMKV,EPHA6
4.643e-03-5.37haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndromeCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome117491682847 EPHA6,CAMK2B,CAMK2A,HCN1,CAMKV,RIMS1,GRM5,GRIN2B,NRG3
4.703e-03-5.36vesicle membranecellular componentGO:0012506125191910850 CAMK2A,STX1A,CAMKV,SNAP25,CAMK2B,CCDC136,GABRB2,SYT1,DLG4
4.729e-03-5.35SAMsmart domainsSM00454833971740 EPHA6,PPFIA3,PPFIA2
4.744e-03-5.35PPFIA3 (PTPRF interacting protein alpha 3)protein interactions85414021945450 PPFIA2,PPFIA3
4.744e-03-5.35CPLX1 (complexin 1)protein interactions108154021945450 SNAP25,STX1A
4.771e-03-5.35kinase bindingmolecular functionGO:001990078071809449 DNM1,GRM5,NRG3,LRRC7,DLG4,RYR2,STX1A
4.776e-03-5.34Z disccellular componentGO:003001813031910850 RYR2,SCN8A,CACNA1C
4.788e-03-5.34protein secretionbiological processGO:000930613231820447 PCLO,CPLX1,STX1A
4.808e-03-5.34bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumourCOSMIC cancer mutationsbone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour6023261682847 GRIN2B,SLC8A3,NRG3,SPTBN2,CAMK2B,SLC4A10,CACNA1C,EDIL3,RIMS1,CACNA1A,DLG4,PCLO,NRXN3,L1CAM,CACNA1E,RYR2,ABLIM1,CACNA1G,FGF14,NRXN2,GABRB2,DLGAP2,SCN8A,MYT1L,SPTBN4,CAMKV
4.812e-03-5.34upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsupper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma9263351682847 CCDC136,GRM5,SLC8A3,GRIN2B,CELF3,CACNA1C,EDIL3,SLC4A10,CAMK2B,PCLO,MCF2L2,DLG4,RASGRF1,CACNA1A,CACNA2D1,NRXN3,L1CAM,RYR2,SYT1,NRXN2,IQSEC2,CACNA1G,PPFIA2,EPHA6,CAMK2A,DLGAP2,STX1A,LRRC7,GABRB2,SCN8A,PPFIA3,DNM1,HCN1,CAMKV,SPTBN4
4.827e-03-5.33chondrosarcomaCOSMIC cancer mutationschondrosarcoma118191682847 RIMS1,RASGRF1,PCLO,LRRC7,DLGAP2,CACNA1E,SLC8A3,HCN1,RYR2
4.865e-03-5.33Hypertrophic cardiomyopathy (HCM)KEGG pathwayshsa05410833716130 CACNA1C,CACNA2D1,RYR2
4.865e-03-5.33Hypertrophic cardiomyopathy (HCM)KEGG pathwaysko05410833716130 CACNA1C,CACNA2D1,RYR2
4.889e-03-5.32establishment of protein localization to extracellular regionbiological processGO:003559213331820447 STX1A,CPLX1,PCLO
4.897e-03-5.32amide bindingmolecular functionGO:003321825441809449 GRIN1,GRIN2B,RYR2,CACNA1A
4.980e-03-5.30LIN7B (lin-7 homolog B, crumbs cell polarity complex component)protein interactions641304121945450 DLG4,GRIN2B
4.985e-03-5.30ovary-other-neoplasmCOSMIC cancer mutationsovary-other-neoplasm12717431682847 SYT1,CACNA1E,RYR2,L1CAM,CACNA2D1,NRXN3,RIMS1,CACNA1A,GRIN1,DLG4,MCF2L2,RASGRF1,PCLO,CAMK2B,CPLX1,CACNA1C,EDIL3,SPTBN2,CELF3,GRIN2B,SLC8A3,NRG3,GRM5,VSNL1,CCDC136,SPTBN4,SNAP25,HCN1,MYT1L,SCN8A,PPFIA3,STX1A,GABRB2,LRRC7,DLGAP2,CAMK2A,CELF5,EPHA6,PPFIA2,IQSEC2,FGF14,NRXN2,ABLIM1
4.998e-03-5.30haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasmCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm24841682847 GRM5,NRG3,CAMK2B,SYT1
4.998e-03-5.30mast_cell_neoplasmCOSMIC cancer mutationsmast_cell_neoplasm24841682847 NRG3,CAMK2B,SYT1,GRM5
5.011e-03-5.30LAM_G_DOMAINprosite domainsPS500253521218637 NRXN2,NRXN3
5.018e-03-5.29regulation of actin filament-based movementbiological processGO:19031154121820447 CACNA1C,RYR2
5.018e-03-5.29positive regulation of amine transportbiological processGO:00519544121820447 SYT1,STX1A
5.049e-03-5.29NTRK2 (neurotrophic receptor tyrosine kinase 2)protein interactions491513531945450 GRIN1,ABLIM1,RASGRF1
5.134e-03-5.27ACTB (actin, beta)protein interactions396526211945450 VSNL1
5.134e-03-5.27Dlgap1 (DLG associated protein 1)protein interactions65040211945450 DLG4
5.134e-03-5.27fem-2 (Protein phosphatase fem-2)protein interactions175217211945450 CAMK2A
5.134e-03-5.27Grin2b (glutamate ionotropic receptor NMDA type subunit 2B)protein interactions24410211945450 DLG4
5.134e-03-5.27Dyrk1a (dual specificity tyrosine phosphorylation regulated kinase 1A)protein interactions25255211945450 DNM1
5.134e-03-5.27ZNF233 (zinc finger protein 233)protein interactions353355211945450 CACNA1A
5.157e-03-5.27neurotransmitter receptor transport postsynaptic membrane to endosomebiological processGO:0098968211820447 LRRC7
5.157e-03-5.27presynapse to nucleus signaling pathwaybiological processGO:0099526211820447 PCLO
5.157e-03-5.27vesicle scissionbiological processGO:0099050211820447 DNM1
5.157e-03-5.27response to nickel cationbiological processGO:0010045211820447 CACNA1G
5.157e-03-5.27cellular alkene metabolic processbiological processGO:0043449211820447 GRIN1
5.157e-03-5.27olefin metabolic processbiological processGO:1900673211820447 GRIN1
5.157e-03-5.27presynaptic signal transductionbiological processGO:0098928211820447 PCLO
5.200e-03-5.26ErbB signaling pathwayKEGG pathwayshsa04012853716130 NRG3,CAMK2A,CAMK2B
5.200e-03-5.26ErbB signaling pathwayKEGG pathwaysko04012853716130 CAMK2B,CAMK2A,NRG3
5.220e-03-5.26PPFIBP2 (PPFIA binding protein 2)protein interactions84954221945450 PPFIA3,PPFIA2
5.220e-03-5.26RYR2 (ryanodine receptor 2)protein interactions62624221945450 RYR2,CACNA1C
5.227e-03-5.25CA3 pyramidal cell dendritecellular componentGO:0097442211910850 SLC4A10
5.227e-03-5.25synaptobrevin 2-SNAP-25-syntaxin-3-complexin complexcellular componentGO:0070554211910850 CPLX1
5.259e-03-5.25USP53 (ubiquitin specific peptidase 53)protein interactions5453213731945450 CAMK2A,SPTBN2,DNM1
5.260e-03-5.25regulation of catecholamine secretionbiological processGO:00504334221820447 SYT1,STX1A
5.260e-03-5.25positive regulation of regulated secretory pathwaybiological processGO:19033074221820447 SYT1,STX1A
5.260e-03-5.25regulation of neurotransmitter receptor activitybiological processGO:00996014221820447 DLG4,DLGAP2
5.265e-03-5.25Laminin_Ginterpro domainsIPR0017914121852149 NRXN3,NRXN2
5.276e-03-5.24GluR_Homer-bdgpfam domainsPF10606211779547 GRM5
5.276e-03-5.24SRRM_Cpfam domainsPF15230211779547 SRRM3
5.276e-03-5.24zf-piccolopfam domainsPF05715211779547 PCLO
5.276e-03-5.24SNAP-25pfam domainsPF00835211779547 SNAP25
5.284e-03-5.24Znf_piccolointerpro domainsIPR008899211852149 PCLO
5.284e-03-5.24Metabotropic_Glu_rcpt_Homer-bdinterpro domainsIPR019588211852149 GRM5
5.284e-03-5.24SRRM_Cinterpro domainsIPR029360211852149 SRRM3
5.284e-03-5.24SNAP-25_dominterpro domainsIPR000928211852149 SNAP25
5.409e-03-5.22suramin bindingmolecular functionGO:0043924211809449 RYR2
5.409e-03-5.22voltage-gated calcium channel activity involved SA node cell action potentialmolecular functionGO:0086059211809449 CACNA1G
5.409e-03-5.22low voltage-gated calcium channel activitymolecular functionGO:0008332211809449 CACNA1G
5.409e-03-5.22syntaxin-3 bindingmolecular functionGO:0030348211809449 SYT1
5.502e-03-5.20pseudomyxoma_peritoneiCOSMIC cancer mutationspseudomyxoma_peritonei58561682847 EDIL3,GRIN2B,DLGAP2,CACNA1E,GRM5,RIMS1
5.502e-03-5.20peritoneum-appendix-other-pseudomyxoma_peritoneiCOSMIC cancer mutationsperitoneum-appendix-other-pseudomyxoma_peritonei58561682847 GRM5,RIMS1,CACNA1E,DLGAP2,GRIN2B,EDIL3
5.524e-03-5.20regulation of neuron projection developmentbiological processGO:001097544351820447 SNAP25,LRRC7,PPFIA2,L1CAM,CAMK2B
5.527e-03-5.20positive regulation of cation transmembrane transportbiological processGO:190406413931820447 RYR2,CACNA2D1,GRIN1
5.547e-03-5.19appendixCOSMIC cancer mutationsappendix58661682847 EDIL3,CACNA1E,DLGAP2,GRIN2B,GRM5,RIMS1
5.585e-03-5.19STX3 (syntaxin 3)protein interactions680914031945450 STX1A,SYT1,SNAP25
5.592e-03-5.19peritoneumCOSMIC cancer mutationsperitoneum58761682847 CACNA1E,GRIN2B,DLGAP2,EDIL3,RIMS1,GRM5
5.658e-03-5.17sarcoplasmic reticulum membranecellular componentGO:00330174321910850 RYR2,CAMK2B
5.717e-03-5.16CACNA1C (calcium voltage-gated channel subunit alpha1 C)protein interactions7754421945450 RYR2,RIMS1
5.717e-03-5.16TMEM254 (transmembrane protein 254)protein interactions801954421945450 SYT1,STX1A
5.729e-03-5.16GABAergic synapseKEGG pathwaysko04727883716130 GABRB2,CACNA1A,CACNA1C
5.729e-03-5.16GABAergic synapseKEGG pathwayshsa04727883716130 GABRB2,CACNA1A,CACNA1C
5.750e-03-5.16protein localization to extracellular regionbiological processGO:007169214131820447 PCLO,CPLX1,STX1A
5.760e-03-5.16regulation of dendritic spine morphogenesisbiological processGO:00610014421820447 PPFIA2,CAMK2B
5.760e-03-5.16synaptic vesicle localizationbiological processGO:00974794421820447 PCLO,DNM1
5.773e-03-5.15metal cation:monoatomic cation antiporter activitymolecular functionGO:01408284221809449 SLC8A3,SLC4A10
5.912e-03-5.13Dilated cardiomyopathyKEGG pathwaysko05414893716130 CACNA1C,CACNA2D1,RYR2
5.912e-03-5.13Dilated cardiomyopathyKEGG pathwayshsa05414893716130 RYR2,CACNA1C,CACNA2D1
5.950e-03-5.12signaling receptor bindingmolecular functionGO:00051021493101809449 CAMK2A,SYT1,FGF14,NRXN2,NRXN3,NRG3,GRM5,RASGRF1,DLG4,EDIL3
5.973e-03-5.12CELSR3 (cadherin EGF LAG seven-pass G-type receptor 3)protein interactions19514521945450 SPTBN4,SPTBN2
6.032e-03-5.11upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsupper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma1946121682847 GRIN2B,PPFIA2,NRXN2,NRXN3,RIMS1,PCLO,CACNA1E,SNAP25,LRRC7,CACNA1C,RYR2,HCN1
6.044e-03-5.11sodium channel activitymolecular functionGO:00052724321809449 SCN8A,HCN1
6.082e-03-5.10larynxCOSMIC cancer mutationslarynx1948121682847 CACNA1E,SNAP25,HCN1,RYR2,NRXN3,RIMS1,PCLO,LRRC7,CACNA1C,PPFIA2,GRIN2B,NRXN2
6.095e-03-5.10amide transportbiological processGO:004288614431820447 CPLX1,PCLO,STX1A
6.130e-03-5.09central_nervous_system-brain-glioma-astrocytoma_Grade_IICOSMIC cancer mutationscentral_nervous_system-brain-glioma-astrocytoma_Grade_II42051682847 CACNA1G,SPTBN4,DLGAP2,CACNA1C,CACNA2D1
6.140e-03-5.09oligoastrocytoma_Grade_IIICOSMIC cancer mutationsoligoastrocytoma_Grade_III26341682847 SLC4A10,RYR2,HCN1,SPTBN2
6.230e-03-5.08regulation of nervous system developmentbiological processGO:005196045651820447 BRINP1,CAMK2B,L1CAM,IQSEC2,GRM5
6.342e-03-5.06I bandcellular componentGO:003167414431910850 CACNA1C,RYR2,SCN8A
6.406e-03-5.05C2_dominterpro domainsIPR00000814331852149 RIMS1,SYT1,PCLO
6.441e-03-5.05ion channel regulator activitymolecular functionGO:009910614031809449 NRXN2,STX1A,FGF14
6.453e-03-5.04terminal boutoncellular componentGO:00431954621910850 CPLX1,GRIN1
6.474e-03-5.04Ion channel transportREACTOME pathwaysR-HSA-98371220941028537 GABRB2,CAMK2A,CAMK2B,RYR2
6.483e-03-5.04GnRH signaling pathwayKEGG pathwaysko04912923716130 CAMK2A,CACNA1C,CAMK2B
6.483e-03-5.04GnRH signaling pathwayKEGG pathwayshsa04912923716130 CAMK2B,CAMK2A,CACNA1C
6.492e-03-5.04positive regulation of secretion by cellbiological processGO:190353228941820447 SYT1,SNAP25,STX1A,VSNL1
6.500e-03-5.04SEMA4G (semaphorin 4G)protein interactions577154721945450 DLG4,CAMK2B
6.522e-03-5.03Transcription Factor, Ets-1gene3d domains1.10.150.5011531447048 EPHA6,PPFIA3,PPFIA2
6.577e-03-5.02protein localization to membranebiological processGO:007265746251820447 NRXN2,SPTBN4,LRRC7,SNAP25,DLG4
6.587e-03-5.02Laminingene3d domains2.10.25.1022641447048 NRG3,NRXN2,NRXN3,EDIL3
6.624e-03-5.02-gene3d domains6.10.140.420211447048 SRRM3
6.772e-03-4.99NAPB (NSF attachment protein beta)protein interactions639084821945450 SYT1,STX1A
6.824e-03-4.99regulation of membrane depolarizationbiological processGO:00032544821820447 CACNA1G,HCN1
6.868e-03-4.98acinar_carcinomaCOSMIC cancer mutationsacinar_carcinoma1978121682847 SLC4A10,DLGAP2,CELF3,MYT1L,SLC8A3,NRXN3,DNM1,CACNA1G,RASGRF1,PCLO,GRM5,CACNA1A
6.868e-03-4.98pancreas-carcinoma-acinar_carcinomaCOSMIC cancer mutationspancreas-carcinoma-acinar_carcinoma1978121682847 SLC4A10,DLGAP2,CELF3,MYT1L,NRXN3,DNM1,SLC8A3,CACNA1G,PCLO,RASGRF1,CACNA1A,GRM5
6.892e-03-4.98pre-mRNA bindingmolecular functionGO:00360024621809449 CELF5,CELF3
6.975e-03-4.97upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsupper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma1485101682847 NRXN3,NRG3,GRIN2B,SCN8A,PCLO,RASGRF1,GRM5,RYR2,HCN1,STX1A
6.999e-03-4.96prostateCOSMIC cancer mutationsprostate13883451682847 NRXN2,IQSEC2,FGF14,PPFIA2,CACNA1G,ABLIM1,CELF5,CAMK2A,DLGAP2,LRRC7,STX1A,GABRB2,EPHA6,SCN8A,PPFIA3,HCN1,SNAP25,SPTBN4,MYT1L,NRG3,SLC8A3,GRIN2B,CCDC136,VSNL1,GRM5,EDIL3,SLC4A10,CACNA1C,CPLX1,CAMK2B,CELF3,SPTBN2,NRXN3,CACNA2D1,PCLO,GRIN1,DLG4,RASGRF1,MCF2L2,CACNA1A,RIMS1,RYR2,CACNA1E,SYT1,L1CAM
7.007e-03-4.96CAMK2B (calcium/calmodulin dependent protein kinase II beta)protein interactions81615231945450 CAMK2B,GRIN2B,CAMK2A
7.026e-03-4.96regulation of plasma membrane bounded cell projection organizationbiological processGO:012003566661820447 L1CAM,PPFIA2,CAMK2B,GRIN2B,LRRC7,SNAP25
7.049e-03-4.95WDR5B (WD repeat domain 5B)protein interactions545544921945450 TMEM266,CAMK2B
7.049e-03-4.95ZNF490 (zinc finger protein 490)protein interactions574744921945450 STX1A,CCDC136
7.055e-03-4.95positive regulation of nervous system developmentbiological processGO:005196229641820447 GRM5,L1CAM,CAMK2B,IQSEC2
7.095e-03-4.95channel regulator activitymolecular functionGO:001624714531809449 NRXN2,STX1A,FGF14
7.125e-03-4.94stomach-carcinoma-adenocarcinomaCOSMIC cancer mutationsstomach-carcinoma-adenocarcinoma15150471682847 NRXN2,PPFIA2,IQSEC2,FGF14,EPHA6,CAMK2A,STX1A,GABRB2,LRRC7,SCN8A,DNM1,MYT1L,HCN1,SNAP25,CCDC136,SLC8A3,CELF3,SPTBN2,EDIL3,SLC4A10,CACNA1C,CAMK2B,CPLX1,MCF2L2,GRIN1,DLG4,CACNA2D1,L1CAM,SYT1,ABLIM1,CACNA1G,CELF5,DLGAP2,PPFIA3,CAMKV,SPTBN4,GRM5,VSNL1,NRG3,GRIN2B,RASGRF1,PCLO,CACNA1A,RIMS1,NRXN3,RYR2,CACNA1E
7.196e-03-4.93non_small_cell_carcinomaCOSMIC cancer mutationsnon_small_cell_carcinoma5198231682847 PCLO,RASGRF1,MCF2L2,CACNA2D1,L1CAM,SYT1,RYR2,CCDC136,GRIN2B,CAMK2B,EDIL3,SLC4A10,PPFIA3,DNM1,SNAP25,CAMKV,ABLIM1,IQSEC2,PPFIA2,NRXN2,EPHA6,LRRC7,CAMK2A
7.196e-03-4.93lung-carcinoma-non_small_cell_carcinomaCOSMIC cancer mutationslung-carcinoma-non_small_cell_carcinoma5198231682847 EPHA6,LRRC7,CAMK2A,ABLIM1,PPFIA2,IQSEC2,NRXN2,SNAP25,CAMKV,PPFIA3,DNM1,CAMK2B,SLC4A10,EDIL3,CCDC136,GRIN2B,L1CAM,SYT1,RYR2,RASGRF1,MCF2L2,PCLO,CACNA2D1
7.230e-03-4.93transporter regulator activitymolecular functionGO:014110814631809449 NRXN2,STX1A,FGF14
7.254e-03-4.93Huntington's diseaseKEGG pathwaysko050161874716130 GRIN1,GRIN2B,GRM5,DLG4
7.254e-03-4.93Huntington's diseaseKEGG pathwayshsa050161874716130 DLG4,GRIN1,GRIN2B,GRM5
7.464e-03-4.90positive regulation of monoatomic ion transmembrane transportbiological processGO:003476715531820447 GRIN1,RYR2,CACNA2D1
7.617e-03-4.88APLP1 (amyloid beta precursor like protein 1)protein interactions3335121945450 GRIN2B,GRIN1
7.675e-03-4.87regulation of protein tyrosine kinase activitybiological processGO:00610975121820447 GRM5,DLG4
7.691e-03-4.87POM121L1P (POM121 transmembrane nucleoporin like 1, pseudogene)protein interactions25812311945450 SPTBN4
7.691e-03-4.87Akt2 (thymoma viral proto-oncogene 2)protein interactions11652311945450 BRINP1
7.691e-03-4.87Lrrc7 (leucine rich repeat containing 7)protein interactions117284311945450 CAMK2A
7.691e-03-4.87Ephb2 (Eph receptor B2)protein interactions13844311945450 L1CAM
7.691e-03-4.87Ap2a1 (adaptor related protein complex 2 subunit alpha 1)protein interactions308578311945450 DNM1
7.691e-03-4.87BCO1 (beta-carotene oxygenase 1)protein interactions53630311945450 ABLIM1
7.691e-03-4.87SMPDL3A (sphingomyelin phosphodiesterase acid like 3A)protein interactions10924311945450 BRINP1
7.691e-03-4.87Baiap2 (brain-specific angiogenesis inhibitor 1-associated protein 2)protein interactions108100311945450 DLG4
7.691e-03-4.87Dlgap2 (DLG associated protein 2)protein interactions116681311945450 GRIN2B
7.691e-03-4.87GOLGA6L5P (golgin A6 family like 5, pseudogene)protein interactions374650311945450 CACNA1A
7.703e-03-4.87mixedCOSMIC cancer mutationsmixed14531682847 CAMK2B,PCLO,MYT1L
7.726e-03-4.86type B pancreatic cell apoptotic processbiological processGO:0097050311820447 RYR2
7.726e-03-4.86membrane depolarization during bundle of His cell action potentialbiological processGO:0086048311820447 CACNA2D1
7.726e-03-4.86phospholipase C-activating G protein-coupled glutamate receptor signaling pathwaybiological processGO:0007206311820447 GRM5
7.726e-03-4.86regulation of SA node cell action potentialbiological processGO:0098907311820447 RYR2
7.726e-03-4.86positive regulation of synaptic vesicle exocytosisbiological processGO:2000302311820447 SYT1
7.726e-03-4.86presynaptic active zone assemblybiological processGO:1904071311820447 PCLO
7.726e-03-4.86trans-synaptic signaling by endocannabinoid, modulating synaptic transmissionbiological processGO:0099553311820447 GRM5
7.726e-03-4.86protein localization to early endosomebiological processGO:1902946311820447 LRRC7
7.726e-03-4.86positive regulation of ATPase-coupled calcium transmembrane transporter activitybiological processGO:1901896311820447 RYR2
7.726e-03-4.86trans-synaptic signaling by lipid, modulating synaptic transmissionbiological processGO:0099552311820447 GRM5
7.726e-03-4.86mammary placode formationbiological processGO:0060596311820447 NRG3
7.726e-03-4.86neuroligin clustering involved in postsynaptic membrane assemblybiological processGO:0097118311820447 NRXN2
7.726e-03-4.86membrane depolarization during atrial cardiac muscle cell action potentialbiological processGO:0098912311820447 CACNA1C
7.726e-03-4.86exocytic insertion of neurotransmitter receptor to postsynaptic membranebiological processGO:0098967311820447 SNAP25
7.726e-03-4.86regulation of endocannabinoid signaling pathwaybiological processGO:2000124311820447 CAMK2A
7.726e-03-4.86response to glycinebiological processGO:1905429311820447 GRIN1
7.731e-03-4.86protein-containing complex localizationbiological processGO:003150315731820447 SNAP25,LRRC7,DLG4
7.731e-03-4.86membrane fusionbiological processGO:006102515731820447 RIMS1,STX1A,SNAP25
7.748e-03-4.86NCAM1 interactionsREACTOME pathwaysR-HSA-4190373721028537 CACNA1G,CACNA1C
7.764e-03-4.86skin-mucosal-malignant_melanomaCOSMIC cancer mutationsskin-mucosal-malignant_melanoma2009121682847 SYT1,SNAP25,GRM5,VSNL1,ABLIM1,NRG3,GRIN2B,CELF3,SPTBN2,EDIL3,CAMK2B,LRRC7
7.764e-03-4.86mucosalCOSMIC cancer mutationsmucosal2009121682847 GRM5,ABLIM1,VSNL1,NRG3,GRIN2B,CELF3,SPTBN2,EDIL3,LRRC7,CAMK2B,SYT1,SNAP25
7.790e-03-4.85calcium channel regulator activitymolecular functionGO:00052464921809449 NRXN2,STX1A
7.800e-03-4.85kidney-carcinoma-clear_cell_renal_cell_carcinomaCOSMIC cancer mutationskidney-carcinoma-clear_cell_renal_cell_carcinoma13924451682847 SPTBN4,CAMKV,HCN1,MYT1L,DNM1,SCN8A,PPFIA3,DLGAP2,LRRC7,STX1A,CELF5,CAMK2A,EPHA6,FGF14,IQSEC2,PPFIA2,CACNA1G,NRXN2,ABLIM1,CACNA1E,SYT1,RYR2,L1CAM,NRXN3,CACNA2D1,CACNA1A,RIMS1,PCLO,DLG4,GRIN1,MCF2L2,RASGRF1,CPLX1,CAMK2B,EDIL3,SLC4A10,CACNA1C,SPTBN2,CELF3,GRIN2B,NRG3,SLC8A3,VSNL1,GRM5,CCDC136
7.800e-03-4.85clear_cell_renal_cell_carcinomaCOSMIC cancer mutationsclear_cell_renal_cell_carcinoma13924451682847 EPHA6,STX1A,LRRC7,CAMK2A,PPFIA2,IQSEC2,FGF14,NRXN2,MYT1L,HCN1,SCN8A,DNM1,SPTBN2,CELF3,CAMK2B,CPLX1,EDIL3,SLC4A10,CACNA1C,CCDC136,SLC8A3,L1CAM,SYT1,DLG4,MCF2L2,GRIN1,CACNA2D1,DLGAP2,CELF5,ABLIM1,CACNA1G,SPTBN4,CAMKV,PPFIA3,GRM5,VSNL1,GRIN2B,NRG3,CACNA1E,RYR2,RIMS1,CACNA1A,RASGRF1,PCLO,NRXN3
7.810e-03-4.85Phenytoin (Antiarrhythmic) Action PathwaySMPDB pathwaysSMP000032777313698 CACNA1C,CACNA1G,RYR2
7.830e-03-4.85synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complexcellular componentGO:0070032311910850 SNAP25
7.830e-03-4.85clathrin-sculpted acetylcholine transport vesicle membranecellular componentGO:0060201311910850 SYT1
7.830e-03-4.85synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complexcellular componentGO:0070033311910850 SNAP25
7.830e-03-4.85clathrin-sculpted acetylcholine transport vesiclecellular componentGO:0060200311910850 SYT1
7.884e-03-4.84pleuraCOSMIC cancer mutationspleura4914221682847 SLC4A10,EDIL3,CAMK2A,CAMK2B,EPHA6,NRXN2,GRIN2B,IQSEC2,PPFIA2,RYR2,CAMKV,CACNA1E,SPTBN4,SYT1,L1CAM,DNM1,PPFIA3,PCLO,MCF2L2,RASGRF1,RIMS1,CACNA1A
7.888e-03-4.84gallbladderCOSMIC cancer mutationsgallbladder2821151682847 RIMS1,CACNA1A,SCN8A,PCLO,RASGRF1,CACNA2D1,SNAP25,SPTBN4,HCN1,IQSEC2,FGF14,CACNA1G,NRG3,EPHA6,CAMK2B
7.888e-03-4.84biliary_tract-gallbladder-carcinoma-adenocarcinomaCOSMIC cancer mutationsbiliary_tract-gallbladder-carcinoma-adenocarcinoma2821151682847 HCN1,SPTBN4,SNAP25,CACNA2D1,PCLO,SCN8A,RASGRF1,CACNA1A,RIMS1,CAMK2B,EPHA6,NRG3,IQSEC2,FGF14,CACNA1G
7.903e-03-4.84NMDAR2_Cpfam domainsPF10565311779547 GRIN2B
7.903e-03-4.84Na_Ca_ex_Cpfam domainsPF16494311779547 SLC8A3
7.903e-03-4.84RYDR_Jsolpfam domainsPF21119311779547 RYR2
7.903e-03-4.84MYT1pfam domainsPF08474311779547 MYT1L
7.903e-03-4.84MAGUK_N_PESTpfam domainsPF10608311779547 DLG4
7.903e-03-4.84CAC1F_Cpfam domainsPF16885311779547 CACNA1C
7.903e-03-4.84cwf21pfam domainsPF08312311779547 SRRM3
7.903e-03-4.84RR_TM4-6pfam domainsPF06459311779547 RYR2
7.903e-03-4.84BRINPpfam domainsPF19052311779547 BRINP1
7.903e-03-4.84RyRpfam domainsPF02026311779547 RYR2
7.903e-03-4.84IQ_SEC7_PHpfam domainsPF16453311779547 IQSEC2
7.916e-03-4.84SPRY2_RyRinterpro domainsIPR035764311852149 RYR2
7.916e-03-4.84mRNA_splic_Cwf21_dominterpro domainsIPR013170311852149 SRRM3
7.916e-03-4.84SPRY1_RyRinterpro domainsIPR035761311852149 RYR2
7.916e-03-4.84CAC1F_Cinterpro domainsIPR031688311852149 CACNA1C
7.916e-03-4.84IQSEC_PHinterpro domainsIPR033742311852149 IQSEC2
7.916e-03-4.84Ryanrecept_TM4-6interpro domainsIPR009460311852149 RYR2
7.916e-03-4.84Na_Ca_Ex_C-exteninterpro domainsIPR032452311852149 SLC8A3
7.916e-03-4.84NMDAR2_Cinterpro domainsIPR018884311852149 GRIN2B
7.916e-03-4.84BRINPinterpro domainsIPR033237311852149 BRINP1
7.916e-03-4.84SPRY3_RyRinterpro domainsIPR035762311852149 RYR2
7.916e-03-4.84Na_Ca_Exinterpro domainsIPR004836311852149 SLC8A3
7.916e-03-4.84Neuregulininterpro domainsIPR040180311852149 NRG3
7.916e-03-4.84Ryanodine_rcptinterpro domainsIPR003032311852149 RYR2
7.916e-03-4.84GABAAb_rcptinterpro domainsIPR002289311852149 GABRB2
7.916e-03-4.84Ryan_receptinterpro domainsIPR013333311852149 RYR2
7.916e-03-4.84RYDR_Jsolinterpro domainsIPR048581311852149 RYR2
7.916e-03-4.84VDCC_T_a1interpro domainsIPR005445311852149 CACNA1G
7.916e-03-4.84Myelin_TFinterpro domainsIPR013681311852149 MYT1L
8.103e-03-4.82beta-1 adrenergic receptor bindingmolecular functionGO:0031697311809449 DLG4
8.103e-03-4.82A2A adenosine receptor bindingmolecular functionGO:0031687311809449 GRM5
8.103e-03-4.82neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentrationmolecular functionGO:0099583311809449 GRM5
8.103e-03-4.82sodium,bicarbonate:chloride antiporter activitymolecular functionGO:0140892311809449 SLC4A10
8.127e-03-4.81positive regulation of developmental processbiological processGO:0051094138591820447 SYT1,RIMS1,CAMK2B,BRINP1,DLG4,IQSEC2,SPTBN4,L1CAM,GRM5
8.134e-03-4.81cell morphogenesisbiological processGO:000090268761820447 DLG4,NRXN3,SNAP25,SPTBN4,EPHA6,L1CAM
8.142e-03-4.81peptidyl-serine phosphorylationbiological processGO:001810516031820447 CAMK2B,CAMK2A,CAMKV
8.186e-03-4.81T-tubulecellular componentGO:00303155221910850 CACNA2D1,CACNA1C
8.203e-03-4.80KRTAP6-3 (keratin associated protein 6-3)protein interactions33796816131945450 CAMK2A,CAMK2B,CELF5
8.206e-03-4.80LIN7A (lin-7 homolog A, crumbs cell polarity complex component)protein interactions88255321945450 GRIN2B,DLG4
8.216e-03-4.80GluR_Homer-bdgsmart domainsSM0122921971740 GRM5
8.216e-03-4.80cwf21smart domainsSM0111521971740 SRRM3
8.268e-03-4.80regulation of actin filament depolymerizationbiological processGO:00308345321820447 SPTBN4,SPTBN2
8.281e-03-4.79positive regulation of cell growthbiological processGO:003030716131820447 L1CAM,RIMS1,SYT1
8.368e-03-4.78positive regulation of secretionbiological processGO:005104731141820447 VSNL1,STX1A,SNAP25,SYT1
8.373e-03-4.78ACTN1 (actinin alpha 1)protein interactions8731241945450 CACNA1C,CAMK2A,CACNA1A,GRM5
8.417e-03-4.78amino acid bindingmolecular functionGO:00165975121809449 GRIN1,GRIN2B
8.418e-03-4.78secretory granulecellular componentGO:003014189771910850 SNAP25,CACNA2D1,LRRC7,CCDC136,DNM1,PPFIA3,SYT1
8.423e-03-4.78cytoplasmic regioncellular componentGO:009956830741910850 PCLO,RIMS1,DLG4,PPFIA3
8.558e-03-4.76large_intestine-colonCOSMIC cancer mutationslarge_intestine-colon129191682847 RYR2,MYT1L,CACNA1G,IQSEC2,SLC8A3,NRXN3,CACNA1A,RIMS1,RASGRF1
8.591e-03-4.76response to organonitrogen compoundbiological processGO:001024391571820447 RYR2,CAMK2A,CACNA1A,GRIN1,CACNA2D1,HCN1,GABRB2
8.591e-03-4.76NS-malignant_melanomaCOSMIC cancer mutationsNS-malignant_melanoma3420171682847 PCLO,GRIN1,CACNA1A,RYR2,CACNA1E,SYT1,NRXN2,NRG3,SLC8A3,FGF14,PPFIA2,EPHA6,SPTBN2,CELF5,CACNA1C,EDIL3,CAMK2B
8.649e-03-4.75regulation of developmental growthbiological processGO:004863831441820447 RIMS1,SYT1,L1CAM,SPTBN4
8.734e-03-4.74BDNF-TrkB SignalingWikiPathwaysWP3676332531023 GRIN1,DLG4
8.814e-03-4.73BEGAIN (brain enriched guanylate kinase associated)protein interactions575965521945450 DLG4,ABLIM1
8.881e-03-4.72establishment or maintenance of epithelial cell apical/basal polaritybiological processGO:00451975521820447 DLG4,LRRC7
8.881e-03-4.72regulation of alternative mRNA splicing, via spliceosomebiological processGO:00003815521820447 CELF3,CELF5
9.011e-03-4.71C2prosite domainsPS5000414231218637 RIMS1,PCLO,SYT1
9.057e-03-4.70Buprenorphine Action PathwaySMPDB pathwaysSMP000068426213698 GRIN1,CACNA1A
9.057e-03-4.70Carfentanil Action PathwaySMPDB pathwaysSMP000041426213698 GRIN1,CACNA1A
9.057e-03-4.70Dihydromorphine Action PathwaySMPDB pathwaysSMP000068926213698 CACNA1A,GRIN1
9.057e-03-4.70Proparacaine Action PathwaySMPDB pathwaysSMP000040326213698 GRIN1,CACNA1A
9.057e-03-4.70Sufentanil Action PathwaySMPDB pathwaysSMP000041726213698 GRIN1,CACNA1A
9.057e-03-4.70Naltrexone Action PathwaySMPDB pathwaysSMP000068726213698 CACNA1A,GRIN1
9.057e-03-4.70Methadyl Acetate Action PathwaySMPDB pathwaysSMP000067826213698 CACNA1A,GRIN1
9.057e-03-4.70Levorphanol Action PathwaySMPDB pathwaysSMP000067326213698 CACNA1A,GRIN1
9.057e-03-4.70Remifentanil Action PathwaySMPDB pathwaysSMP000041626213698 CACNA1A,GRIN1
9.057e-03-4.70Pentazocine Action PathwaySMPDB pathwaysSMP000068626213698 CACNA1A,GRIN1
9.057e-03-4.70Bupivacaine Action PathwaySMPDB pathwaysSMP000039326213698 GRIN1,CACNA1A
9.057e-03-4.70Oxybuprocaine Action PathwaySMPDB pathwaysSMP000040026213698 CACNA1A,GRIN1
9.057e-03-4.70Hydrocodone Action PathwaySMPDB pathwaysSMP000041126213698 CACNA1A,GRIN1
9.057e-03-4.70Alvimopan Action PathwaySMPDB pathwaysSMP000068526213698 CACNA1A,GRIN1
9.057e-03-4.70Fentanyl Action PathwaySMPDB pathwaysSMP000041526213698 CACNA1A,GRIN1
9.057e-03-4.70Oxymorphone Action PathwaySMPDB pathwaysSMP000041226213698 GRIN1,CACNA1A
9.057e-03-4.70Ethylmorphine Action PathwaySMPDB pathwaysSMP000068126213698 CACNA1A,GRIN1
9.057e-03-4.70Chloroprocaine Action PathwaySMPDB pathwaysSMP000039426213698 GRIN1,CACNA1A
9.057e-03-4.70Propoxyphene Action PathwaySMPDB pathwaysSMP000067226213698 CACNA1A,GRIN1
9.057e-03-4.70Diphenoxylate Action PathwaySMPDB pathwaysSMP000067526213698 CACNA1A,GRIN1
9.057e-03-4.70Ketobemidone Action PathwaySMPDB pathwaysSMP000069026213698 GRIN1,CACNA1A
9.057e-03-4.70Tramadol Action Action PathwaySMPDB pathwaysSMP000067126213698 GRIN1,CACNA1A
9.057e-03-4.70Mepivacaine Action PathwaySMPDB pathwaysSMP000039926213698 GRIN1,CACNA1A
9.057e-03-4.70Hydromorphone Action PathwaySMPDB pathwaysSMP000041026213698 GRIN1,CACNA1A
9.057e-03-4.70Dimethylthiambutene Action PathwaySMPDB pathwaysSMP000068026213698 CACNA1A,GRIN1
9.057e-03-4.70Levobupivacaine Action PathwaySMPDB pathwaysSMP000039726213698 CACNA1A,GRIN1
9.057e-03-4.70Procaine Action PathwaySMPDB pathwaysSMP000040226213698 GRIN1,CACNA1A
9.057e-03-4.70Dezocine Action PathwaySMPDB pathwaysSMP000067626213698 GRIN1,CACNA1A
9.057e-03-4.70Prilocaine Action PathwaySMPDB pathwaysSMP000040126213698 CACNA1A,GRIN1
9.057e-03-4.70Ropivacaine Action PathwaySMPDB pathwaysSMP000040426213698 GRIN1,CACNA1A
9.057e-03-4.70Levomethadyl Acetate Action Action PathwaySMPDB pathwaysSMP000067726213698 GRIN1,CACNA1A
9.057e-03-4.70Naloxone Action PathwaySMPDB pathwaysSMP000068826213698 GRIN1,CACNA1A
9.057e-03-4.70Alfentanil Action PathwaySMPDB pathwaysSMP000041326213698 GRIN1,CACNA1A
9.057e-03-4.70Dibucaine Action PathwaySMPDB pathwaysSMP000039626213698 GRIN1,CACNA1A
9.057e-03-4.70Levallorphan Action PathwaySMPDB pathwaysSMP000068326213698 CACNA1A,GRIN1
9.057e-03-4.70Oxycodone Action PathwaySMPDB pathwaysSMP000040926213698 GRIN1,CACNA1A
9.057e-03-4.70Anileridine Action PathwaySMPDB pathwaysSMP000067426213698 CACNA1A,GRIN1
9.057e-03-4.70Escitalopram Action PathwaySMPDB pathwaysSMP000042526213698 CACNA1A,GRIN1
9.057e-03-4.70Benzocaine Action PathwaySMPDB pathwaysSMP000039226213698 GRIN1,CACNA1A
9.057e-03-4.70Cocaine Action PathwaySMPDB pathwaysSMP000039526213698 CACNA1A,GRIN1
9.057e-03-4.703-Methylthiofentanyl Action PathwaySMPDB pathwaysSMP000067926213698 CACNA1A,GRIN1
9.066e-03-4.70transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialmolecular functionGO:19043155321809449 GABRB2,GRIN2B
9.125e-03-4.70RAB3IL1 (RAB3A interacting protein like 1)protein interactions58665621945450 PPFIA3,STX1A
9.125e-03-4.70MIP (major intrinsic protein of lens fiber)protein interactions42845621945450 STX1A,SYT1
9.150e-03-4.69regulation of insulin secretionbiological processGO:005079616731820447 STX1A,SNAP25,VSNL1
9.208e-03-4.69growth conecellular componentGO:003042616531910850 RASGRF1,L1CAM,SNAP25
9.212e-03-4.69RALBP1 (ralA binding protein 1)protein interactions1092816831945450 ABLIM1,DLG4,CCDC136
9.442e-03-4.66ZBTB32 (zinc finger and BTB domain containing 32)protein interactions270335721945450 CAMK2B,CAMK2A
9.450e-03-4.66regulation of muscle contractionbiological processGO:000693716931820447 RYR2,SLC8A3,CACNA1C
9.472e-03-4.66monoatomic cation homeostasisbiological processGO:005508050551820447 GRM5,RYR2,SLC8A3,GRIN1,SLC4A10
9.476e-03-4.66oesophagus-lower_third-carcinoma-adenocarcinomaCOSMIC cancer mutationsoesophagus-lower_third-carcinoma-adenocarcinoma6302261682847 CACNA1E,RYR2,CACNA1A,RIMS1,PCLO,RASGRF1,MCF2L2,CACNA2D1,NRXN3,SPTBN2,CAMK2B,CACNA1C,VSNL1,GRM5,GRIN2B,NRG3,MYT1L,SPTBN4,HCN1,EPHA6,DLGAP2,GABRB2,LRRC7,CELF5,CACNA1G,NRXN2
9.611e-03-4.64protein localizationbiological processGO:00081041954111820447 CPLX1,NRXN2,SPTBN4,STX1A,DLG4,HCN1,PCLO,RYR2,LRRC7,SNAP25,RIMS1
9.702e-03-4.64circulatory system processbiological processGO:000301350851820447 RYR2,CACNA2D1,CACNA1G,CACNA1C,SCN8A
9.737e-03-4.63neurotransmitter receptor activity involved in regulation of postsynaptic membrane potentialmolecular functionGO:00995295521809449 GABRB2,GRIN2B
9.741e-03-4.63-gene3d domains1.10.287.14904521447048 PPFIA3,CCDC136
9.753e-03-4.63Nalbuphine Action PathwaySMPDB pathwaysSMP000069127213698 CACNA1A,GRIN1
9.753e-03-4.63Desipramine Action PathwaySMPDB pathwaysSMP000042327213698 CACNA1A,GRIN1
9.757e-03-4.63establishment of vesicle localizationbiological processGO:005165017131820447 DNM1,PPFIA2,SNAP25
9.766e-03-4.63germ_cell_tumourCOSMIC cancer mutationsgerm_cell_tumour86771682847 PCLO,EPHA6,CAMK2A,CAMKV,CACNA2D1,LRRC7,CAMK2B
9.899e-03-4.62cellular macromolecule localizationbiological processGO:00707271962111820447 PCLO,RYR2,LRRC7,STX1A,HCN1,RIMS1,SNAP25,CPLX1,NRXN2,SPTBN4,DLG4
9.905e-03-4.61EPHB-mediated forward signalingREACTOME pathwaysR-HSA-39286624221028537 GRIN1,GRIN2B
9.912e-03-4.61peptidyl-serine modificationbiological processGO:001820917231820447 CAMKV,CAMK2B,CAMK2A
9.919e-03-4.61Single Helix bingene3d domains1.20.5.580311447048 CPLX1
9.919e-03-4.61-gene3d domains1.10.490.160311447048 RYR2
9.985e-03-4.61site of polarized growthcellular componentGO:003042717031910850 SNAP25,RASGRF1,L1CAM
9.999e-03-4.61cell adhesionbiological processGO:000715594271820447 NRXN3,LRRC7,L1CAM,PPFIA2,NRXN2,EDIL3,DLG4
1.008e-02-4.60calcium-dependent phospholipid bindingmolecular functionGO:00055445621809449 PCLO,SYT1
1.013e-02-4.59SLC1A1 (solute carrier family 1 member 1)protein interactions650517431945450 DLG4,GRIN1,GRIN2B
1.013e-02-4.59phospholipid bindingmolecular functionGO:000554348951809449 SPTBN4,SPTBN2,PCLO,SYT1,DNM1
1.017e-02-4.59establishment or maintenance of apical/basal cell polaritybiological processGO:00350885921820447 DLG4,LRRC7
1.017e-02-4.59establishment or maintenance of bipolar cell polaritybiological processGO:00612455921820447 DLG4,LRRC7
1.017e-02-4.59negative regulation of actin filament polymerizationbiological processGO:00308375921820447 SPTBN2,SPTBN4
1.017e-02-4.59regulation of dendritic spine developmentbiological processGO:00609985921820447 CAMK2B,PPFIA2
1.024e-02-4.58Snap25 (synaptosome associated protein 25)protein interactions25012411945450 STX1A
1.024e-02-4.58Psmc5 (proteasome 26S subunit, ATPase 5)protein interactions81827411945450 CAMK2A
1.024e-02-4.58Stxbp1 (syntaxin binding protein 1)protein interactions25558411945450 STX1A
1.024e-02-4.58SRL (sarcalumenin)protein interactions6345411945450 VSNL1
1.024e-02-4.58HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)protein interactions10021411945450 HCN1
1.024e-02-4.58Grb2 (growth factor receptor bound protein 2)protein interactions81504411945450 DNM1
1.024e-02-4.58Amph (amphiphysin)protein interactions60668411945450 DNM1
1.024e-02-4.58Baz2b (bromodomain adjacent to zinc finger domain, 2B)protein interactions407823411945450 CACNA2D1
1.024e-02-4.58SLC6A2 (solute carrier family 6 member 2)protein interactions6530411945450 STX1A
1.025e-02-4.58monoatomic ion homeostasisbiological processGO:005080151551820447 GRIN1,RYR2,SLC8A3,SLC4A10,GRM5
1.029e-02-4.58regulation of atrial cardiac muscle cell action potentialbiological processGO:0098910411820447 RYR2
1.029e-02-4.58regulation of grooming behaviorbiological processGO:2000821411820447 DLG4
1.029e-02-4.58regulation of calcium ion-dependent exocytosis of neurotransmitterbiological processGO:1903233411820447 SYT1
1.029e-02-4.58maintenance of presynaptic active zone structurebiological processGO:0048790411820447 PCLO
1.029e-02-4.58regulation of AV node cell action potentialbiological processGO:0098904411820447 RYR2
1.029e-02-4.58positive regulation of norepinephrine secretionbiological processGO:0010701411820447 STX1A
1.029e-02-4.58calcium-dependent activation of synaptic vesicle fusionbiological processGO:0099502411820447 SYT1
1.029e-02-4.58positive regulation of high voltage-gated calcium channel activitybiological processGO:1901843411820447 CACNA2D1
1.029e-02-4.58trans-synaptic signaling by endocannabinoidbiological processGO:0099542411820447 GRM5
1.029e-02-4.58trans-synaptic signaling by lipidbiological processGO:0099541411820447 GRM5
1.029e-02-4.58positive regulation of synaptic vesicle fusion to presynaptic active zone membranebiological processGO:0031632411820447 SYT1
1.029e-02-4.58left ventricular cardiac muscle tissue morphogenesisbiological processGO:0003220411820447 RYR2
1.029e-02-4.58positive regulation of synaptic vesicle membrane organizationbiological processGO:1901634411820447 SYT1
1.029e-02-4.58negative regulation of dendritic spine maintenancebiological processGO:1902951411820447 GRIN2B
1.039e-02-4.57brain developmentbiological processGO:000742072461820447 SPTBN2,GRIN2B,NRG3,SLC4A10,BRINP1,GRIN1
1.043e-02-4.56clathrin-sculpted glutamate transport vesiclecellular componentGO:0060199411910850 SYT1
1.043e-02-4.56HCN channel complexcellular componentGO:0098855411910850 HCN1
1.043e-02-4.56clathrin-sculpted glutamate transport vesicle membranecellular componentGO:0060203411910850 SYT1
1.044e-02-4.56C2_domain_sfinterpro domainsIPR03589217131852149 PCLO,SYT1,RIMS1
1.047e-02-4.56Lidocaine (Local Anaesthetic) Action PathwaySMPDB pathwaysSMP000039828213698 CACNA1A,GRIN1
1.050e-02-4.56protein homotetramerizationbiological processGO:00512896021820447 HCN1,DNM1
1.050e-02-4.56regulation of cytosolic calcium ion concentrationbiological processGO:00514806021820447 RYR2,GRM5
1.052e-02-4.55Synaphinpfam domainsPF05835411779547 CPLX1
1.052e-02-4.55AbLIM_anchorpfam domainsPF16182411779547 ABLIM1
1.052e-02-4.55Ion_trans_Npfam domainsPF08412411779547 HCN1
1.052e-02-4.55VWA_Npfam domainsPF08399411779547 CACNA2D1
1.052e-02-4.55VGCC_alpha2pfam domainsPF08473411779547 CACNA2D1
1.052e-02-4.55PDZ_assocpfam domainsPF10600411779547 DLG4
1.052e-02-4.55Bravo_FIGEYpfam domainsPF13882411779547 L1CAM
1.054e-02-4.55Rim-likeinterpro domainsIPR039032411852149 RIMS1
1.054e-02-4.55Synaphininterpro domainsIPR008849411852149 CPLX1
1.054e-02-4.55VDCC_a2/dsuinterpro domainsIPR013680411852149 CACNA2D1
1.054e-02-4.55DLG1_PEST_dominterpro domainsIPR019590411852149 DLG4
1.054e-02-4.55Neurofascin/L1/NrCAM_Cinterpro domainsIPR026966411852149 L1CAM
1.054e-02-4.55AbLIM_anchorinterpro domainsIPR032402411852149 ABLIM1
1.054e-02-4.55DLG1-likeinterpro domainsIPR016313411852149 DLG4
1.054e-02-4.55VWA_Ninterpro domainsIPR013608411852149 CACNA2D1
1.054e-02-4.55DLG1-4_PDZ_associnterpro domainsIPR019583411852149 DLG4
1.054e-02-4.55Ion_trans_Ninterpro domainsIPR013621411852149 HCN1
1.054e-02-4.55VDCC_L_a1suinterpro domainsIPR005446411852149 CACNA1C
1.055e-02-4.55central nervous system neuron differentiationbiological processGO:002195317631820447 SPTBN4,BRINP1,SLC4A10
1.057e-02-4.55positive regulation of molecular functionbiological processGO:0044093119281820447 GRM5,CAMK2A,CACNA2D1,DLG4,GRIN2B,CACNA1C,RYR2,RASGRF1
1.065e-02-4.54pancreatic_intraepithelial_neoplasia_(PanIN)COSMIC cancer mutationspancreatic_intraepithelial_neoplasia_(PanIN)67361682847 LRRC7,CACNA1G,GRIN2B,RYR2,GRM5,SPTBN2
1.065e-02-4.54pancreas-pancreatic_intraepithelial_neoplasia_(PanIN)COSMIC cancer mutationspancreas-pancreatic_intraepithelial_neoplasia_(PanIN)67361682847 CACNA1G,LRRC7,GRIN2B,RYR2,GRM5,SPTBN2
1.075e-02-4.53Toxicity of botulinum toxin type E (BoNT/E)REACTOME pathwaysR-HSA-5250992311028537 SNAP25
1.075e-02-4.53Toxicity of botulinum toxin type B (BoNT/B)REACTOME pathwaysR-HSA-5250958311028537 SYT1
1.075e-02-4.53Toxicity of botulinum toxin type G (BoNT/G)REACTOME pathwaysR-HSA-5250989311028537 SYT1
1.076e-02-4.53TTC5 (tetratricopeptide repeat domain 5)protein interactions918756121945450 CAMK2B,CAMK2A
1.077e-02-4.53ERBB4 (erb-b2 receptor tyrosine kinase 4)protein interactions206617831945450 NRG3,LRRC7,DLG4
1.079e-02-4.53structural constituent of presynaptic active zonemolecular functionGO:0098882411809449 PCLO
1.079e-02-4.53calcium ion sensor activitymolecular functionGO:0061891411809449 SYT1
1.079e-02-4.53ryanodine-sensitive calcium-release channel activitymolecular functionGO:0005219411809449 RYR2
1.079e-02-4.53cytoskeletal protein-membrane anchor activitymolecular functionGO:0106006411809449 SPTBN4
1.079e-02-4.53G protein-coupled receptor activity involved in regulation of postsynaptic membrane potentialmolecular functionGO:0099530411809449 GRM5
1.103e-02-4.51-gene3d domains1.20.5.1104821447048 SNAP25,STX1A
1.110e-02-4.50FAM9C (family with sequence similarity 9 member C)protein interactions1714846221945450 CCDC136,STX1A
1.112e-02-4.50Serotonergic synapseKEGG pathwayshsa047261123716130 GABRB2,CACNA1A,CACNA1C
1.121e-02-4.49Codeine Action PathwaySMPDB pathwaysSMP000040529213698 GRIN1,CACNA1A
1.122e-02-4.49protein kinase bindingmolecular functionGO:001990170161809449 DLG4,LRRC7,NRG3,RYR2,GRM5,DNM1
1.123e-02-4.49testis-germ_cell_tumour-non_seminomaCOSMIC cancer mutationstestis-germ_cell_tumour-non_seminoma48751682847 CAMKV,CAMK2A,CACNA2D1,CAMK2B,EPHA6
1.126e-02-4.49urinary_tract-bladder-carcinoma-transitional_cell_carcinomaCOSMIC cancer mutationsurinary_tract-bladder-carcinoma-transitional_cell_carcinoma6040251682847 GRIN2B,NRG3,SLC8A3,GRM5,SPTBN2,CELF3,NRXN3,CACNA2D1,RIMS1,GRIN1,MCF2L2,RASGRF1,SYT1,L1CAM,IQSEC2,NRXN2,ABLIM1,LRRC7,GABRB2,STX1A,CELF5,DNM1,PPFIA3,SPTBN4,HCN1
1.131e-02-4.48transitional_cell_carcinomaCOSMIC cancer mutationstransitional_cell_carcinoma6042251682847 GRM5,NRG3,SLC8A3,GRIN2B,CELF3,SPTBN2,MCF2L2,RASGRF1,GRIN1,RIMS1,NRXN3,CACNA2D1,L1CAM,SYT1,ABLIM1,NRXN2,IQSEC2,CELF5,GABRB2,LRRC7,STX1A,PPFIA3,DNM1,HCN1,SPTBN4
1.139e-02-4.47primary_central_nervous_system_lymphomaCOSMIC cancer mutationsprimary_central_nervous_system_lymphoma68361682847 SPTBN2,PPFIA2,SPTBN4,RYR2,NRG3,CACNA2D1
1.139e-02-4.47haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphomaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma68361682847 SPTBN2,RYR2,NRG3,CACNA2D1,SPTBN4,PPFIA2
1.144e-02-4.47GABAARBETAprints domainsPR0116031522720 GABRB2
1.144e-02-4.47TVDCCALPHA1prints domainsPR0162931522720 CACNA1G
1.144e-02-4.47NACAEXCHNGRprints domainsPR0125931522720 SLC8A3
1.144e-02-4.47RYANODINERprints domainsPR0079531522720 RYR2
1.157e-02-4.46regulation of molecular functionbiological processGO:00650092005111820447 DLG4,SLC8A3,CACNA2D1,FGF14,CAMK2A,GRM5,DLGAP2,RASGRF1,RYR2,CACNA1C,GRIN2B
1.157e-02-4.46human chr7q11.23chromosome locationhuman chr7q11.238522613450 SRRM3,STX1A
1.165e-02-4.45metal ion bindingmolecular functionGO:00468724239191809449 NRXN3,GRIN1,GRIN2B,RIMS1,RYR2,ABLIM1,SYT1,PCLO,SCN8A,CACNA1E,NRXN2,CACNA1A,SLC8A3,EDIL3,CACNA2D1,CACNA1C,CAMK2A,VSNL1,MYT1L
1.168e-02-4.45LamGsmart domainsSM00282402971740 NRXN2,NRXN3
1.168e-02-4.45response to metal ionbiological processGO:001003834341820447 RYR2,SYT1,CACNA1G,DLG4
1.169e-02-4.45non_seminomaCOSMIC cancer mutationsnon_seminoma49251682847 EPHA6,CAMK2B,CACNA2D1,CAMK2A,CAMKV
1.179e-02-4.44MAP3K10 (mitogen-activated protein kinase kinase kinase 10)protein interactions42946421945450 DLG4,DNM1
1.179e-02-4.44TMEM14C (transmembrane protein 14C)protein interactions515226421945450 SYT1,STX1A
1.198e-02-4.42Imipramine Action PathwaySMPDB pathwaysSMP000042230213698 GRIN1,CACNA1A
1.222e-02-4.40lung-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationslung-carcinoma-squamous_cell_carcinoma14664461682847 DNM1,SCN8A,SNAP25,HCN1,MYT1L,IQSEC2,FGF14,PPFIA2,NRXN2,LRRC7,STX1A,GABRB2,CAMK2A,EPHA6,CACNA2D1,DLG4,MCF2L2,GRIN1,SYT1,L1CAM,SLC8A3,CCDC136,CAMK2B,CACNA1C,EDIL3,SLC4A10,SPTBN2,CELF3,PPFIA3,SPTBN4,CAMKV,CACNA1G,ABLIM1,DLGAP2,CELF5,NRXN3,CACNA1A,RIMS1,PCLO,RASGRF1,CACNA1E,RYR2,GRIN2B,NRG3,VSNL1,GRM5
1.230e-02-4.40KRTAP6-2 (keratin associated protein 6-2)protein interactions33796718731945450 CAMK2A,CELF5,CAMK2B
1.259e-02-4.37faceCOSMIC cancer mutationsface2139121682847 SLC8A3,NRXN2,CACNA2D1,NRG3,GRIN2B,MCF2L2,PPFIA3,GRM5,ABLIM1,HCN1,LRRC7,EPHA6
1.260e-02-4.37negative regulation of protein depolymerizationbiological processGO:19018806621820447 SPTBN4,SPTBN2
1.267e-02-4.37lung-carcinoid-endocrine_tumourCOSMIC cancer mutationslung-carcinoid-endocrine_tumour50251682847 CAMK2A,CAMKV,NRXN3,CAMK2B,EPHA6
1.268e-02-4.37regulation of hormone levelsbiological processGO:001081754351820447 SNAP25,STX1A,CPLX1,VSNL1,PCLO
1.269e-02-4.37liver-carcinomaCOSMIC cancer mutationsliver-carcinoma15337471682847 ABLIM1,CACNA1G,DLGAP2,CELF5,PPFIA3,SPTBN4,CAMKV,GRM5,VSNL1,GRIN2B,NRG3,RIMS1,CACNA1A,RASGRF1,PCLO,NRXN3,CACNA1E,RYR2,PPFIA2,IQSEC2,FGF14,NRXN2,EPHA6,STX1A,GABRB2,LRRC7,CAMK2A,SCN8A,DNM1,MYT1L,SNAP25,HCN1,CCDC136,SLC8A3,SPTBN2,CELF3,CAMK2B,CPLX1,EDIL3,SLC4A10,CACNA1C,MCF2L2,GRIN1,DLG4,CACNA2D1,L1CAM,SYT1
1.275e-02-4.36regulation of cellular component sizebiological processGO:003253535241820447 DNM1,L1CAM,SPTBN4,SPTBN2
1.277e-02-4.36Fluoxetine Action PathwaySMPDB pathwaysSMP000042631213698 GRIN1,CACNA1A
1.279e-02-4.36Snap23 (synaptosomal-associated protein 23)protein interactions20619511945450 STX1A
1.279e-02-4.36CDK5R2 (cyclin dependent kinase 5 regulatory subunit 2)protein interactions8941511945450 CAMK2A
1.279e-02-4.36SETD6 (SET domain containing 6, protein lysine methyltransferase)protein interactions79918511945450 PPFIA2
1.279e-02-4.36HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)protein interactions57657511945450 HCN1
1.279e-02-4.36CCM2L (CCM2 like scaffold protein)protein interactions140706511945450 CAMK2B
1.279e-02-4.36CACNA1E (calcium voltage-gated channel subunit alpha1 E)protein interactions777511945450 CACNA1E
1.279e-02-4.36Calu (calumenin)protein interactions12321511945450 CACNA2D1
1.280e-02-4.36EPH-ephrin mediated repulsion of cellsREACTOME pathwaysR-HSA-39286654821028537 DNM1,EPHA6
1.284e-02-4.35Purkinje myocyte to ventricular cardiac muscle cell signalingbiological processGO:0086029511820447 RYR2
1.284e-02-4.35presynaptic dense core vesicle exocytosisbiological processGO:0099525511820447 SNAP25
1.284e-02-4.35general adaptation syndrome, behavioral processbiological processGO:0051867511820447 HCN1
1.284e-02-4.35bundle of His cell action potentialbiological processGO:0086043511820447 CACNA2D1
1.284e-02-4.35gephyrin clustering involved in postsynaptic density assemblybiological processGO:0097116511820447 NRXN2
1.284e-02-4.35glutamate receptor clusteringbiological processGO:0097688511820447 DLG4
1.284e-02-4.35neuronal dense core vesicle exocytosisbiological processGO:0099011511820447 SNAP25
1.284e-02-4.35regulation of postsynaptic neurotransmitter receptor activitybiological processGO:0098962511820447 DLGAP2
1.284e-02-4.35membrane depolarization during SA node cell action potentialbiological processGO:0086046511820447 CACNA1G
1.284e-02-4.35AMPA glutamate receptor clusteringbiological processGO:0097113511820447 DLG4
1.284e-02-4.35positive regulation of the force of heart contractionbiological processGO:0098735511820447 RYR2
1.284e-02-4.35bundle of His cell to Purkinje myocyte signalingbiological processGO:0086028511820447 CACNA2D1
1.287e-02-4.35ZNF696 (zinc finger protein 696)protein interactions799436721945450 STX1A,CCDC136
1.296e-02-4.35cell-cell adhesionbiological processGO:009860954651820447 L1CAM,NRXN2,DLG4,NRXN3,LRRC7
1.297e-02-4.35excitatory postsynaptic potentialbiological processGO:00600796721820447 GRIN2B,GRIN1
1.299e-02-4.34oesophagus-carcinoma-adenocarcinomaCOSMIC cancer mutationsoesophagus-carcinoma-adenocarcinoma13112431682847 CACNA2D1,MCF2L2,GRIN1,SYT1,L1CAM,SLC8A3,CCDC136,EDIL3,CACNA1C,SLC4A10,CPLX1,CAMK2B,CELF3,SPTBN2,SCN8A,HCN1,SNAP25,MYT1L,NRXN2,FGF14,IQSEC2,PPFIA2,CAMK2A,GABRB2,STX1A,LRRC7,EPHA6,NRXN3,PCLO,RASGRF1,CACNA1A,RIMS1,RYR2,CACNA1E,NRG3,GRIN2B,VSNL1,GRM5,PPFIA3,SPTBN4,CACNA1G,CELF5,DLGAP2
1.302e-02-4.34clathrin-sculpted monoamine transport vesicle membranecellular componentGO:0070083511910850 SYT1
1.302e-02-4.34clathrin-sculpted monoamine transport vesiclecellular componentGO:0070081511910850 SYT1
1.309e-02-4.34adherens junctioncellular componentGO:000591218831910850 SPTBN4,LRRC7,DLG4
1.314e-02-4.33GKAPpfam domainsPF03359511779547 DLGAP2
1.316e-02-4.33Na/HCO3_transptinterpro domainsIPR003024511852149 SLC4A10
1.316e-02-4.33Znf_C2H2C_sfinterpro domainsIPR036060511852149 MYT1L
1.316e-02-4.33SAPAPinterpro domainsIPR005026511852149 DLGAP2
1.322e-02-4.33haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_associated_with_MDSCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_associated_with_MDS17731682847 CACNA1E,GRIN2B,L1CAM
1.322e-02-4.33acute_myeloid_leukaemia_associated_with_MDSCOSMIC cancer mutationsacute_myeloid_leukaemia_associated_with_MDS17731682847 CACNA1E,GRIN2B,L1CAM
1.324e-02-4.32ZNF835 (zinc finger protein 835)protein interactions904856821945450 STX1A,CCDC136
1.325e-02-4.32localization within membranebiological processGO:005166854951820447 NRXN2,SPTBN4,SNAP25,LRRC7,DLG4
1.330e-02-4.32prostate-adenomaCOSMIC cancer mutationsprostate-adenoma1634101682847 SPTBN2,SYT1,GABRB2,LRRC7,GRIN1,RASGRF1,SLC8A3,NRXN3,FGF14,IQSEC2
1.347e-02-4.31metal ion sensor activitymolecular functionGO:0140784511809449 SYT1
1.354e-02-4.30CHpfam domainsPF003076721779547 SPTBN2,SPTBN4
1.358e-02-4.30Methadone Action PathwaySMPDB pathwaysSMP000040832213698 GRIN1,CACNA1A
1.358e-02-4.30Citalopram Action PathwaySMPDB pathwaysSMP000042432213698 GRIN1,CACNA1A
1.358e-02-4.30Nicotine Action PathwaySMPDB pathwaysSMP000043132213698 GRIN1,CACNA1A
1.361e-02-4.30C2smart domainsSM002391223971740 RIMS1,SYT1,PCLO
1.361e-02-4.30BAGE2 (BAGE family member 2 (pseudogene))protein interactions853196921945450 EPHA6,CACNA2D1
1.366e-02-4.29plasma membrane signaling receptor complexcellular componentGO:009880219131910850 GRIN2B,DLG4,GRIN1
1.366e-02-4.29head_neckCOSMIC cancer mutationshead_neck15361471682847 FGF14,IQSEC2,PPFIA2,NRXN2,STX1A,GABRB2,LRRC7,CAMK2A,EPHA6,DNM1,SCN8A,SNAP25,HCN1,MYT1L,SLC8A3,CCDC136,CPLX1,CAMK2B,EDIL3,CACNA1C,SLC4A10,SPTBN2,CELF3,CACNA2D1,GRIN1,DLG4,MCF2L2,SYT1,L1CAM,CACNA1G,ABLIM1,DLGAP2,CELF5,PPFIA3,SPTBN4,CAMKV,GRIN2B,NRG3,VSNL1,GRM5,NRXN3,CACNA1A,RIMS1,PCLO,RASGRF1,CACNA1E,RYR2
1.388e-02-4.28positive regulation of cell projection organizationbiological processGO:003134636141820447 LRRC7,DLG4,CAMK2B,L1CAM
1.390e-02-4.28Ras signaling pathwayKEGG pathwayshsa040142264716130 GRIN1,RASGRF1,GRIN2B,FGF14
1.399e-02-4.27ACTN4 (actinin alpha 4)protein interactions8136341945450 GRIN1,LRRC7,CAMK2B,CAMK2A
1.399e-02-4.27Signaling by GPCRREACTOME pathwaysR-HSA-3727901299101028537 SPTBN2,GRIN2B,CAMK2A,DLG4,CAMK2B,GRM5,GRIN1,RASGRF1,SPTBN4,NRG3
1.410e-02-4.26head developmentbiological processGO:006032277461820447 GRIN1,NRG3,BRINP1,SLC4A10,GRIN2B,SPTBN2
1.423e-02-4.25ovary-carcinomaCOSMIC cancer mutationsovary-carcinoma93371682847 EDIL3,CAMK2A,CAMKV,CAMK2B,SYT1,EPHA6,NRXN3
1.427e-02-4.25regulation of peptide hormone secretionbiological processGO:009027619731820447 VSNL1,STX1A,SNAP25
1.431e-02-4.25HCN channelsREACTOME pathwaysR-HSA-1296061411028537 HCN1
1.431e-02-4.25Toxicity of botulinum toxin type A (BoNT/A)REACTOME pathwaysR-HSA-5250968411028537 SNAP25
1.433e-02-4.25CAMK2D (calcium/calmodulin dependent protein kinase II delta)protein interactions81719831945450 CAMK2B,GRIN2B,CAMK2A
1.435e-02-4.24protein-containing complex organizationbiological processGO:00439332067111820447 GRIN2B,CELF5,DNM1,SYT1,RIMS1,SNAP25,SPTBN4,DLG4,HCN1,GRIN1,CELF3
1.445e-02-4.24bone-femur-other-chondroblastomaCOSMIC cancer mutationsbone-femur-other-chondroblastoma18331682847 NRG3,FGF14,SYT1
1.447e-02-4.24fertilizationbiological processGO:000956619831820447 SPTBN4,CCDC136,RIMS1
1.448e-02-4.23kidneyCOSMIC cancer mutationskidney15380471682847 CACNA2D1,MCF2L2,DLG4,GRIN1,SYT1,L1CAM,SLC8A3,CCDC136,CACNA1C,SLC4A10,EDIL3,CAMK2B,CPLX1,CELF3,SPTBN2,DNM1,SCN8A,HCN1,SNAP25,MYT1L,NRXN2,PPFIA2,FGF14,IQSEC2,CAMK2A,LRRC7,GABRB2,STX1A,EPHA6,NRXN3,RASGRF1,PCLO,CACNA1A,RIMS1,RYR2,CACNA1E,NRG3,GRIN2B,GRM5,VSNL1,PPFIA3,CAMKV,SPTBN4,CACNA1G,ABLIM1,CELF5,DLGAP2
1.453e-02-4.23DAPK1 (death associated protein kinase 1)protein interactions161219931945450 ABLIM1,SPTBN2,STX1A
1.471e-02-4.22RhoGEFpfam domainsPF006217021779547 RASGRF1,MCF2L2
1.477e-02-4.22DH-domaininterpro domainsIPR0002197021852149 MCF2L2,RASGRF1
1.486e-02-4.21regulation of peptide secretionbiological processGO:000279120031820447 STX1A,SNAP25,VSNL1
1.486e-02-4.21regulation of peptide transportbiological processGO:009008720031820447 VSNL1,STX1A,SNAP25
1.486e-02-4.21photoreceptor inner segmentcellular componentGO:00019177121910850 DNM1,SNAP25
1.492e-02-4.21C2 domaingene3d domains2.60.40.15015631447048 RIMS1,SYT1,PCLO
1.500e-02-4.20cation bindingmolecular functionGO:00431694341191809449 EDIL3,CACNA2D1,CACNA1A,SLC8A3,NRXN2,CACNA1E,MYT1L,CAMK2A,VSNL1,CACNA1C,RIMS1,GRIN2B,GRIN1,NRXN3,SCN8A,PCLO,ABLIM1,SYT1,RYR2
1.509e-02-4.19response to nitrogen compoundbiological processGO:1901698102171820447 GABRB2,HCN1,CACNA2D1,GRIN1,CACNA1A,CAMK2A,RYR2
1.517e-02-4.19DBL_dom_sfinterpro domainsIPR0358997121852149 RASGRF1,MCF2L2
1.522e-02-4.19LVDCCALPHA1prints domainsPR0163041522720 CACNA1C
1.526e-02-4.18intracellular calcium ion homeostasisbiological processGO:000687420231820447 GRM5,SLC8A3,RYR2
1.526e-02-4.18receptor internalizationbiological processGO:00316237321820447 SNAP25,DNM1
1.526e-02-4.18negative regulation of protein polymerizationbiological processGO:00322727321820447 SPTBN2,SPTBN4
1.526e-02-4.18chemical synaptic transmission, postsynapticbiological processGO:00995657321820447 GRIN1,GRIN2B
1.532e-02-4.18CIBAR2 (CBY1 interacting BAR domain containing 2)protein interactions339145611945450 CAMK2B
1.532e-02-4.18Nos1 (nitric oxide synthase 1)protein interactions24598611945450 DLG4
1.539e-02-4.17Purkinje myocyte to ventricular cardiac muscle cell communicationbiological processGO:0086068611820447 RYR2
1.539e-02-4.17acrosomal vesicle exocytosisbiological processGO:0060478611820447 RIMS1
1.539e-02-4.17imitative learningbiological processGO:0098596611820447 NRXN2
1.539e-02-4.17postsynaptic density protein 95 clusteringbiological processGO:0097119611820447 NRXN2
1.539e-02-4.17positive regulation of inhibitory postsynaptic potentialbiological processGO:0097151611820447 RIMS1
1.539e-02-4.17clustering of voltage-gated sodium channelsbiological processGO:0045162611820447 SPTBN4
1.539e-02-4.17general adaptation syndromebiological processGO:0051866611820447 HCN1
1.539e-02-4.17ERBB4-ERBB4 signaling pathwaybiological processGO:0038138611820447 NRG3
1.539e-02-4.17vocal learningbiological processGO:0042297611820447 NRXN2
1.539e-02-4.17presynaptic active zone organizationbiological processGO:1990709611820447 PCLO
1.539e-02-4.17cellular response to histaminebiological processGO:0071420611820447 GABRB2
1.539e-02-4.17positive regulation of dopamine secretionbiological processGO:0033603611820447 SYT1
1.539e-02-4.17mammary gland formationbiological processGO:0060592611820447 NRG3
1.543e-02-4.17scaffold protein bindingmolecular functionGO:00971107021809449 DLG4,CACNA1G
1.554e-02-4.16GIMAP5 (GTPase, IMAP family member 5)protein interactions553407421945450 STX1A,SYT1
1.560e-02-4.16basal dendritecellular componentGO:0097441611910850 SLC4A10
1.560e-02-4.16extrinsic component of presynaptic membranecellular componentGO:0098888611910850 SNAP25
1.571e-02-4.15testisCOSMIC cancer mutationstestis73361682847 CACNA2D1,LRRC7,CAMK2B,CAMK2A,CAMKV,EPHA6
1.575e-02-4.15Ins145_P3_recpfam domainsPF08709611779547 RYR2
1.575e-02-4.15Na_trans_cytoplpfam domainsPF11933611779547 SCN8A
1.575e-02-4.15RIH_assocpfam domainsPF08454611779547 RYR2
1.575e-02-4.15RYDR_ITPRpfam domainsPF01365611779547 RYR2
1.575e-02-4.15Syndecanpfam domainsPF01034611779547 NRXN3
1.575e-02-4.15GEDpfam domainsPF02212611779547 DNM1
1.575e-02-4.15zf-C2HCpfam domainsPF01530611779547 MYT1L
1.575e-02-4.15Dynamin_Mpfam domainsPF01031611779547 DNM1
1.577e-02-4.15GED_dominterpro domainsIPR020850611852149 DNM1
1.577e-02-4.15Syndecan/Neurexin_dominterpro domainsIPR027789611852149 NRXN3
1.577e-02-4.15GEDinterpro domainsIPR003130611852149 DNM1
1.577e-02-4.15Ins145_P3_rcptinterpro domainsIPR014821611852149 RYR2
1.577e-02-4.15Na_trans_cytoplinterpro domainsIPR024583611852149 SCN8A
1.577e-02-4.15Dynamin_GTPase_CSinterpro domainsIPR019762611852149 DNM1
1.577e-02-4.15RIH_dominterpro domainsIPR000699611852149 RYR2
1.577e-02-4.15RyR/IP3R_RIH_dom_sfinterpro domainsIPR035910611852149 RYR2
1.577e-02-4.15Dynamin_stalkinterpro domainsIPR000375611852149 DNM1
1.577e-02-4.15Ryanodine_IP3_receptorinterpro domainsIPR015925611852149 RYR2
1.577e-02-4.15RIH_assoc-dominterpro domainsIPR013662611852149 RYR2
1.578e-02-4.15ion bindingmolecular functionGO:00431676007241809449 CACNA1A,CACNA2D1,CACNA1E,DNM1,MYT1L,VSNL1,NRXN3,EPHA6,HCN1,GRIN1,ABLIM1,PCLO,SCN8A,RYR2,SLC8A3,EDIL3,NRXN2,CAMKV,CACNA1C,CAMK2A,RIMS1,CAMK2B,GRIN2B,SYT1
1.603e-02-4.13regulation of neurogenesisbiological processGO:005076737741820447 GRM5,L1CAM,CAMK2B,BRINP1
1.606e-02-4.13regulation of calcium ion transmembrane transporter activitybiological processGO:19010197521820447 CACNA2D1,RYR2
1.614e-02-4.13calcium-induced calcium release activitymolecular functionGO:0048763611809449 RYR2
1.614e-02-4.13D1 dopamine receptor bindingmolecular functionGO:0031748611809449 DLG4
1.614e-02-4.13chloride channel inhibitor activitymolecular functionGO:0019869611809449 STX1A
1.614e-02-4.13sodium:bicarbonate symporter activitymolecular functionGO:0008510611809449 SLC4A10
1.631e-02-4.12pancreas-carcinomaCOSMIC cancer mutationspancreas-carcinoma14770461682847 SPTBN4,PPFIA3,DLGAP2,CELF5,ABLIM1,CACNA1G,CACNA1E,RYR2,CACNA1A,RIMS1,PCLO,RASGRF1,NRXN3,VSNL1,GRM5,GRIN2B,NRG3,MYT1L,SNAP25,HCN1,SCN8A,DNM1,EPHA6,LRRC7,STX1A,GABRB2,CAMK2A,IQSEC2,FGF14,PPFIA2,NRXN2,L1CAM,SYT1,DLG4,MCF2L2,GRIN1,CACNA2D1,SPTBN2,CELF3,CPLX1,CAMK2B,EDIL3,SLC4A10,CACNA1C,CCDC136,SLC8A3
1.635e-02-4.11SRI (sorcin)protein interactions67177621945450 RYR2,CACNA1C
1.637e-02-4.11MAGUK_N_PESTsmart domainsSM0127741971740 DLG4
1.641e-02-4.11Galactose-bd-like_sfinterpro domainsIPR0089797421852149 EDIL3,EPHA6
1.647e-02-4.11negative regulation of protein-containing complex disassemblybiological processGO:00432427621820447 SPTBN4,SPTBN2
1.647e-02-4.11cytoskeletal protein bindingmolecular functionGO:000809298971809449 DNM1,CAMK2B,CACNA1C,ABLIM1,SPTBN2,SNAP25,SPTBN4
1.649e-02-4.11neuromuscular junctioncellular componentGO:00315947521910850 DLG4,SLC8A3
1.653e-02-4.10establishment of protein localizationbiological processGO:0045184129181820447 DLG4,STX1A,CPLX1,LRRC7,RYR2,SNAP25,RIMS1,PCLO
1.675e-02-4.09hairy_cell_leukaemiaCOSMIC cancer mutationshairy_cell_leukaemia144091682847 MYT1L,CELF5,RYR2,EDIL3,GRM5,PCLO,PPFIA2,NRXN2,SLC8A3
1.675e-02-4.09haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemiaCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia144091682847 MYT1L,RYR2,CELF5,EDIL3,GRM5,PCLO,PPFIA2,NRXN2,SLC8A3
1.676e-02-4.09LITAF (lipopolysaccharide induced TNF factor)protein interactions95167721945450 CACNA1C,VSNL1
1.676e-02-4.09Htt (huntingtin)protein interactions151947721945450 STX1A,SNAP25
1.691e-02-4.08cortical actin cytoskeletoncellular componentGO:00308647621910850 SPTBN2,SPTBN4
1.696e-02-4.08EPHB2 (EPH receptor B2)protein interactions204821131945450 GRIN2B,EPHA6,GRIN1
1.704e-02-4.07regulation of actin filament-based processbiological processGO:003297038441820447 SPTBN2,SPTBN4,CACNA1C,RYR2
1.708e-02-4.07neoplasmCOSMIC cancer mutationsneoplasm14787461682847 GRIN2B,NRG3,SLC8A3,VSNL1,GRM5,CCDC136,CPLX1,CAMK2B,CACNA1C,EDIL3,SPTBN2,CELF3,NRXN3,CACNA2D1,RIMS1,CACNA1A,PCLO,RASGRF1,GRIN1,DLG4,MCF2L2,CACNA1E,SYT1,RYR2,L1CAM,FGF14,IQSEC2,PPFIA2,CACNA1G,NRXN2,ABLIM1,DLGAP2,LRRC7,STX1A,GABRB2,CELF5,CAMK2A,EPHA6,DNM1,SCN8A,PPFIA3,SNAP25,SPTBN4,CAMKV,HCN1,MYT1L
1.717e-02-4.06LRP8 (LDL receptor related protein 8)protein interactions78047821945450 DLG4,GRIN1
1.730e-02-4.06regulation of cardiac muscle contractionbiological processGO:00551177821820447 RYR2,CACNA1C
1.744e-02-4.05Felodipine Metabolism PathwaySMPDB pathwaysSMP00006193113698 CACNA1C
1.759e-02-4.04TRAF3IP3 (TRAF3 interacting protein 3)protein interactions803427921945450 CCDC136,STX1A
1.776e-02-4.03GABA-ergic synapsecellular componentGO:00989827821910850 GABRB2,PCLO
1.777e-02-4.03positive regulation of transmembrane transportbiological processGO:003476421431820447 RYR2,CACNA2D1,GRIN1
1.786e-02-4.03HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)protein interactions610711945450 HCN1
1.786e-02-4.03ABCC9 (ATP binding cassette subfamily C member 9)protein interactions10060711945450 STX1A
1.786e-02-4.03Dlg4 (discs large MAGUK scaffold protein 4)protein interactions13385711945450 GRIN1
1.786e-02-4.03ATP4B (ATPase H+/K+ transporting subunit beta)protein interactions496711945450 STX1A
1.786e-02-4.03RIMBP2 (RIMS binding protein 2)protein interactions23504711945450 CACNA1A
1.786e-02-4.03SV2B (synaptic vesicle glycoprotein 2B)protein interactions9899711945450 SYT1
1.786e-02-4.03ZNF479 (zinc finger protein 479)protein interactions90827711945450 STX1A
1.786e-02-4.03FRMPD4 (FERM and PDZ domain containing 4)protein interactions9758711945450 GRM5
1.786e-02-4.03KCNE2 (potassium voltage-gated channel subfamily E regulatory subunit 2)protein interactions9992711945450 CACNA1C
1.794e-02-4.02modulation of inhibitory postsynaptic potentialbiological processGO:0098828711820447 RIMS1
1.794e-02-4.02regulation of synaptic vesicle primingbiological processGO:0010807711820447 STX1A
1.794e-02-4.02interneuron migration from the subpallium to the cortexbiological processGO:0021830711820447 NRG3
1.794e-02-4.02observational learningbiological processGO:0098597711820447 NRXN2
1.794e-02-4.02SA node cell to atrial cardiac muscle cell signalingbiological processGO:0086018711820447 CACNA1G
1.794e-02-4.02dense core granule exocytosisbiological processGO:1990504711820447 SNAP25
1.794e-02-4.02spontaneous neurotransmitter secretionbiological processGO:0061669711820447 SYT1
1.794e-02-4.02hydrocarbon metabolic processbiological processGO:0120252711820447 GRIN1
1.794e-02-4.02SA node cell action potentialbiological processGO:0086015711820447 CACNA1G
1.794e-02-4.02positive regulation of voltage-gated calcium channel activitybiological processGO:1901387711820447 CACNA2D1
1.794e-02-4.02positive regulation of long-term synaptic depressionbiological processGO:1900454711820447 IQSEC2
1.794e-02-4.02regulation of ATPase-coupled calcium transmembrane transporter activitybiological processGO:1901894711820447 RYR2
1.801e-02-4.02BLOC1S6 (biogenesis of lysosomal organelles complex 1 subunit 6)protein interactions262588021945450 STX1A,CCDC136
1.808e-02-4.01G_DYNAMIN_1prosite domainsPS00410611218637 DNM1
1.808e-02-4.01GEDprosite domainsPS51388611218637 DNM1
1.818e-02-4.01axon hillockcellular componentGO:0043203711910850 SPTBN4
1.818e-02-4.01cerebellar mossy fibercellular componentGO:0044300711910850 DLG4
1.834e-02-4.00Ion transport by P-type ATPasesREACTOME pathwaysR-HSA-9368375821028537 CAMK2B,CAMK2A
1.838e-02-4.00Dynamin_GTPaseinterpro domainsIPR001401711852149 DNM1
1.838e-02-4.00Dynamininterpro domainsIPR022812711852149 DNM1
1.838e-02-4.00Znf_C2H2Cinterpro domainsIPR002515711852149 MYT1L
1.844e-02-3.99visual perceptionbiological processGO:000760121731820447 SLC4A10,RIMS1,ABLIM1
1.849e-02-3.99organic acid bindingmolecular functionGO:004317720731809449 GRIN1,GRIN2B,RYR2
1.882e-02-3.97cytoplasmcellular componentGO:000573712081391910850 MCF2L2,CAMK2B,BRINP1,SYT1,FGF14,CELF5,RYR2,TMEM266,GRM5,GRIN1,CCDC136,GRIN2B,ABLIM1,STX1A,CAMKV,CACNA2D1,PCLO,PPFIA3,DNM1,LRRC7,SLC8A3,VSNL1,RASGRF1,GABRB2,RIMS1,CELF3,CPLX1,CACNA1G,PPFIA2,CAMK2A,SCN8A,CACNA1A,SPTBN2,IQSEC2,SNAP25,DLGAP2,CACNA1C,DLG4,SPTBN4
1.886e-02-3.97LINC00839 (long intergenic non-protein coding RNA 839)protein interactions848568221945450 L1CAM,RYR2
1.886e-02-3.97VPS11 (VPS11 core subunit of CORVET and HOPS complexes)protein interactions558238221945450 TMEM266,STX1A
1.893e-02-3.97CDK5 (cyclin dependent kinase 5)protein interactions102022031945450 GRM5,DNM1,STX1A
1.897e-02-3.96human chr2p24.2chromosome locationhuman chr2p24.21012613450 VSNL1
1.899e-02-3.96NAHCO3TRSPRTprints domainsPR0123251522720 SLC4A10
1.901e-02-3.96thyroid-carcinoma-Hurthle_cell_carcinomaCOSMIC cancer mutationsthyroid-carcinoma-Hurthle_cell_carcinoma20331682847 SCN8A,RIMS1,SPTBN4
1.901e-02-3.96Hurthle_cell_carcinomaCOSMIC cancer mutationsHurthle_cell_carcinoma20331682847 SPTBN4,RIMS1,SCN8A
1.903e-02-3.96DH_2prosite domainsPS500107021218637 MCF2L2,RASGRF1
1.905e-02-3.96Amyotrophic lateral sclerosis (ALS)KEGG pathwayshsa05014512716130 GRIN2B,GRIN1
1.905e-02-3.96Amyotrophic lateral sclerosis (ALS)KEGG pathwaysko05014512716130 GRIN1,GRIN2B
1.913e-02-3.96regulation of growthbiological processGO:004000860351820447 NRG3,SYT1,RIMS1,SPTBN4,L1CAM
1.934e-02-3.95sensory perception of light stimulusbiological processGO:005095322131820447 SLC4A10,RIMS1,ABLIM1
1.937e-02-3.94sarcomerecellular componentGO:003001721831910850 SCN8A,RYR2,CACNA1C
1.939e-02-3.94calcium-dependent protein bindingmolecular functionGO:00483067921809449 SNAP25,SYT1
1.944e-02-3.94actin filament bindingmolecular functionGO:005101521131809449 SPTBN2,SPTBN4,ABLIM1
1.944e-02-3.94positive regulation of ion transmembrane transporter activitybiological processGO:00324148321820447 RYR2,CACNA2D1
1.944e-02-3.94regulation of amine transportbiological processGO:00519528321820447 SYT1,STX1A
1.944e-02-3.94spliceosomal complex assemblybiological processGO:00002458321820447 CELF3,CELF5
1.945e-02-3.94CH_dominterpro domainsIPR0017158121852149 SPTBN2,SPTBN4
1.954e-02-3.94BSG (basigin (Ok blood group))protein interactions68260851945450 DNM1,CACNA1C,CAMK2A,SPTBN4,ABLIM1
1.964e-02-3.93regulation of cell growthbiological processGO:000155840141820447 RIMS1,SYT1,NRG3,L1CAM
1.974e-02-3.93IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)protein interactions99228421945450 BRINP1,IQSEC2
1.974e-02-3.93SPTA1 (spectrin alpha, erythrocytic 1)protein interactions67088421945450 SPTBN2,SPTBN4
1.974e-02-3.92IP3 receptor type 1 binding core, RIH domaingene3d domains1.25.10.30611447048 RYR2
1.974e-02-3.92-gene3d domains4.10.320.30611447048 MYT1L
1.974e-02-3.92Dynamin, middle domaingene3d domains1.20.120.1240611447048 DNM1
1.976e-02-3.92FBXO2 (F-box protein 2)protein interactions2623240341945450 EDIL3,L1CAM,CACNA2D1,GRIN1
1.986e-02-3.92otherCOSMIC cancer mutationsother14843461682847 SYT1,L1CAM,CACNA2D1,GRIN1,DLG4,MCF2L2,CPLX1,CAMK2B,CACNA1C,EDIL3,SPTBN2,CELF3,SLC8A3,CCDC136,SNAP25,HCN1,MYT1L,DNM1,SCN8A,GABRB2,STX1A,LRRC7,CAMK2A,EPHA6,FGF14,IQSEC2,PPFIA2,NRXN2,CACNA1E,RYR2,NRXN3,CACNA1A,RIMS1,PCLO,RASGRF1,GRIN2B,NRG3,VSNL1,GRM5,SPTBN4,CAMKV,PPFIA3,DLGAP2,CELF5,CACNA1G,ABLIM1
1.989e-02-3.92regulation of release of sequestered calcium ion into cytosolbiological processGO:00512798421820447 CACNA1C,RYR2
1.989e-02-3.92regulation of sodium ion transportbiological processGO:00020288421820447 FGF14,SPTBN4
1.991e-02-3.92CH_dom_sfinterpro domainsIPR0368728221852149 SPTBN4,SPTBN2
1.992e-02-3.92EF_hand_dominterpro domainsIPR00204821831852149 VSNL1,RYR2,CACNA1E
2.004e-02-3.91axon guidancebiological processGO:000741122431820447 L1CAM,EPHA6,NRXN3
2.004e-02-3.91neuron projection guidancebiological processGO:009748522431820447 EPHA6,L1CAM,NRXN3
2.016e-02-3.90ConA-like_dom_sfinterpro domainsIPR01332021931852149 NRXN2,RYR2,NRXN3
2.038e-02-3.89RASSF4 (Ras association domain family member 4)protein interactions83937811945450 DLG4
2.038e-02-3.89PEX5L (peroxisomal biogenesis factor 5 like)protein interactions51555811945450 HCN1
2.038e-02-3.89C18orf32 (chromosome 18 open reading frame 32)protein interactions497661811945450 CACNA1C
2.038e-02-3.89PKD1L1-AS1 (PKD1L1 antisense RNA 1)protein interactions80099811945450 CACNA2D1
2.038e-02-3.89Bod1 (biorientation of chromosomes in cell division 1)protein interactions69556811945450 SPTBN2
2.038e-02-3.89PRSS33 (serine protease 33)protein interactions260429811945450 CACNA2D1
2.038e-02-3.89TAFA1 (TAFA chemokine like family member 1)protein interactions407738811945450 NRXN3
2.038e-02-3.89ZNF441 (zinc finger protein 441)protein interactions126068811945450 STX1A
2.038e-02-3.89KRTAP23-1 (keratin associated protein 23-1)protein interactions337963811945450 CAMK2A
2.047e-02-3.89lung-carcinoma-bronchioloalveolar_adenocarcinomaCOSMIC cancer mutationslung-carcinoma-bronchioloalveolar_adenocarcinoma77861682847 EPHA6,SPTBN4,SYT1,CAMK2B,CAMK2A,CAMKV
2.047e-02-3.89bronchioloalveolar_adenocarcinomaCOSMIC cancer mutationsbronchioloalveolar_adenocarcinoma77861682847 CAMK2A,CAMKV,SPTBN4,CAMK2B,SYT1,EPHA6
2.047e-02-3.89ERBB4 signaling pathwaybiological processGO:0038130811820447 NRG3
2.047e-02-3.89regulation of synapse structural plasticitybiological processGO:0051823811820447 CAMK2B
2.047e-02-3.89positive regulation of vesicle fusionbiological processGO:0031340811820447 SYT1
2.047e-02-3.89dense core granule transportbiological processGO:1901950811820447 PPFIA2
2.047e-02-3.89positive regulation of neuron projection arborizationbiological processGO:0150012811820447 DLG4
2.047e-02-3.89dense core granule cytoskeletal transportbiological processGO:0099519811820447 PPFIA2
2.047e-02-3.89neuron-neuron synaptic transmissionbiological processGO:0007270811820447 DLGAP2
2.075e-02-3.88clathrin-sculpted gamma-aminobutyric acid transport vesiclecellular componentGO:0061200811910850 SYT1
2.075e-02-3.88presynaptic endocytic zone membranecellular componentGO:0098835811910850 DNM1
2.075e-02-3.88cell body fibercellular componentGO:0070852811910850 SPTBN4
2.075e-02-3.88clathrin-sculpted gamma-aminobutyric acid transport vesicle membranecellular componentGO:0061202811910850 SYT1
2.075e-02-3.88paranodal junctioncellular componentGO:0033010811910850 SPTBN2
2.078e-02-3.87positive regulation of insulin secretionbiological processGO:00320248621820447 VSNL1,SNAP25
2.086e-02-3.87Morphine Action PathwaySMPDB pathwaysSMP000040640213698 CACNA1A,GRIN1
2.094e-02-3.87Syntaxinpfam domainsPF00804811779547 STX1A
2.094e-02-3.87VHPpfam domainsPF02209811779547 ABLIM1
2.097e-02-3.86GPCR_3_mtglu_rcptinterpro domainsIPR000162811852149 GRM5
2.097e-02-3.86Villin_headpiece_dom_sfinterpro domainsIPR036886811852149 ABLIM1
2.097e-02-3.86Villin_headpieceinterpro domainsIPR003128811852149 ABLIM1
2.103e-02-3.86PCNT (pericentrin)protein interactions511622931945450 MYT1L,DNM1,SPTBN2
2.107e-02-3.86ZF_CCHHCprosite domainsPS51802711218637 MYT1L
2.124e-02-3.85regulation of protein depolymerizationbiological processGO:19018798721820447 SPTBN2,SPTBN4
2.124e-02-3.85associative learningbiological processGO:00083068721820447 SNAP25,GRIN1
2.135e-02-3.85Cell adhesion molecules (CAMs)KEGG pathwaysko045141433716130 NRXN3,L1CAM,NRXN2
2.135e-02-3.85Cell adhesion molecules (CAMs)KEGG pathwayshsa045141433716130 L1CAM,NRXN2,NRXN3
2.146e-02-3.84CDC37 (cell division cycle 37, HSP90 cochaperone)protein interactions1114062351945450 EPHA6,CAMK2B,SPTBN4,CAMK2A,STX1A
2.146e-02-3.84adenosine receptor bindingmolecular functionGO:0031685811809449 GRM5
2.146e-02-3.84sodium ion bindingmolecular functionGO:0031402811809449 SCN8A
2.153e-02-3.84HSPG2 (heparan sulfate proteoglycan 2)protein interactions33398821945450 CAMKV,CACNA1A
2.153e-02-3.84BTN2A2 (butyrophilin subfamily 2 member A2)protein interactions103858821945450 SYT1,STX1A
2.175e-02-3.83phosphatidylinositol-4,5-bisphosphate bindingmolecular functionGO:00055468421809449 SYT1,DNM1
2.197e-02-3.82receptor complexcellular componentGO:004323540941910850 GRIN1,GABRB2,GRIN2B,DLG4
2.213e-02-3.81bone-knee-chondrosarcoma-synovialCOSMIC cancer mutationsbone-knee-chondrosarcoma-synovial811682847 RYR2
2.213e-02-3.81synovialCOSMIC cancer mutationssynovial811682847 RYR2
2.216e-02-3.81multicellular organismal response to stressbiological processGO:00335558921820447 BRINP1,HCN1
2.216e-02-3.81multicellular organism growthbiological processGO:00352648921820447 SPTBN2,SLC4A10
2.219e-02-3.81skin-face-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsskin-face-carcinoma-squamous_cell_carcinoma2036111682847 HCN1,LRRC7,MCF2L2,PPFIA3,GRM5,ABLIM1,SLC8A3,NRXN2,NRG3,CACNA2D1,GRIN2B
2.240e-02-3.80ErbB Signaling PathwayWikiPathwaysWP673542531023 NRG3,CAMK2A
2.246e-02-3.80TMEM60 (transmembrane protein 60)protein interactions850259021945450 STX1A,SYT1
2.261e-02-3.79nodularCOSMIC cancer mutationsnodular151591682847 SPTBN2,CELF5,HCN1,SPTBN4,SNAP25,PPFIA3,ABLIM1,DNM1,GRIN2B
2.290e-02-3.78RDH8 (retinol dehydrogenase 8)protein interactions50700911945450 CAMK2B
2.290e-02-3.78Plk2 (polo like kinase 2)protein interactions20620911945450 CACNA2D1
2.290e-02-3.78HYAL3 (hyaluronidase 3)protein interactions8372911945450 CAMK2A
2.290e-02-3.78PMFBP1 (polyamine modulated factor 1 binding protein 1)protein interactions83449911945450 CAMK2A
2.290e-02-3.78ZNF599 (zinc finger protein 599)protein interactions148103911945450 CCDC136
2.290e-02-3.78MPND (MPN domain containing)protein interactions84954911945450 DLG4
2.290e-02-3.78SOBP (sine oculis binding protein homolog)protein interactions55084911945450 CELF3
2.292e-02-3.78MAP1A (microtubule associated protein 1A)protein interactions41309121945450 DLG4,GRIN2B
2.300e-02-3.77release of sequestered calcium ion into cytosol by sarcoplasmic reticulumbiological processGO:0014808911820447 RYR2
2.300e-02-3.77receptor diffusion trappingbiological processGO:0098953911820447 DLG4
2.300e-02-3.77neurotransmitter receptor diffusion trappingbiological processGO:0099628911820447 DLG4
2.300e-02-3.77adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathwaybiological processGO:0007196911820447 GRM5
2.300e-02-3.77positive regulation of long-term neuronal synaptic plasticitybiological processGO:0048170911820447 GRM5
2.300e-02-3.77spontaneous synaptic transmissionbiological processGO:0098814911820447 SYT1
2.300e-02-3.77postsynaptic neurotransmitter receptor diffusion trappingbiological processGO:0098970911820447 DLG4
2.300e-02-3.77SA node cell to atrial cardiac muscle cell communicationbiological processGO:0086070911820447 CACNA1G
2.300e-02-3.77positive regulation of synapse maturationbiological processGO:0090129911820447 CAMK2B
2.315e-02-3.77Dbl homology (DH) domaingene3d domains1.20.900.107121447048 MCF2L2,RASGRF1
2.331e-02-3.76presynaptic endocytic zonecellular componentGO:0098833911910850 DNM1
2.331e-02-3.76chromaffin granule membranecellular componentGO:0042584911910850 SYT1
2.331e-02-3.76photoreceptor ribbon synapsecellular componentGO:0098684911910850 DNM1
2.331e-02-3.76spectrin-associated cytoskeletoncellular componentGO:0014731911910850 SPTBN2
2.331e-02-3.76junctional sarcoplasmic reticulum membranecellular componentGO:0014701911910850 RYR2
2.332e-02-3.76uveal_tractCOSMIC cancer mutationsuveal_tract58751682847 MYT1L,PCLO,CAMK2B,GRIN2B,CACNA1E
2.333e-02-3.76small molecule bindingmolecular functionGO:00360946197241809449 CACNA1A,CACNA2D1,CACNA1E,DNM1,MYT1L,VSNL1,NRXN3,EPHA6,HCN1,GRIN1,ABLIM1,PCLO,SCN8A,RYR2,SLC8A3,EDIL3,NRXN2,CAMKV,CACNA1C,CAMK2A,RIMS1,GRIN2B,CAMK2B,SYT1
2.339e-02-3.76RLN1 (relaxin 1)protein interactions60139221945450 CACNA2D1,EPHA6
2.339e-02-3.76KDM5B (lysine demethylase 5B)protein interactions107659221945450 GRIN2B,CACNA1A
2.353e-02-3.75Band_3_cytopfam domainsPF07565911779547 SLC4A10
2.353e-02-3.75Na_Ca_expfam domainsPF01699911779547 SLC8A3
2.353e-02-3.75Calx-betapfam domainsPF03160911779547 SLC8A3
2.357e-02-3.75CalX-like_sfinterpro domainsIPR038081911852149 SLC8A3
2.357e-02-3.75NaCa_Exmembinterpro domainsIPR004837911852149 SLC8A3
2.357e-02-3.75Calx_betainterpro domainsIPR003644911852149 SLC8A3
2.357e-02-3.75NCX_ion-bd_dom_sfinterpro domainsIPR044880911852149 SLC8A3
2.357e-02-3.75Band3_cytoplasmic_dominterpro domainsIPR013769911852149 SLC4A10
2.357e-02-3.75positive regulation of transporter activitybiological processGO:00324119221820447 RYR2,CACNA2D1
2.378e-02-3.74guanyl-nucleotide exchange factor activitymolecular functionGO:000508522831809449 IQSEC2,RASGRF1,MCF2L2
2.384e-02-3.74DISC1 (DISC1 scaffold protein)protein interactions2718542741945450 PPFIA3,SPTBN4,MYT1L,CCDC136
2.404e-02-3.73HPprosite domainsPS51089811218637 ABLIM1
2.412e-02-3.72G protein-coupled glutamate receptor activitymolecular functionGO:0098988911809449 GRM5
2.412e-02-3.727SK snRNA bindingmolecular functionGO:0097322911809449 CELF3
2.412e-02-3.72adenylate cyclase inhibiting G protein-coupled glutamate receptor activitymolecular functionGO:0001640911809449 GRM5
2.412e-02-3.72intracellularly cAMP-activated cation channel activitymolecular functionGO:0005222911809449 HCN1
2.412e-02-3.72calcium-dependent protein serine/threonine kinase activitymolecular functionGO:0009931911809449 CAMK2B
2.427e-02-3.72intracellular monoatomic cation homeostasisbiological processGO:003000342841820447 GRM5,SLC4A10,SLC8A3,RYR2
2.429e-02-3.72stomachCOSMIC cancer mutationsstomach15550471682847 GRIN2B,NRG3,VSNL1,GRM5,CACNA1E,RYR2,NRXN3,RIMS1,CACNA1A,PCLO,RASGRF1,DLGAP2,CELF5,CACNA1G,ABLIM1,SPTBN4,CAMKV,PPFIA3,CPLX1,CAMK2B,SLC4A10,CACNA1C,EDIL3,SPTBN2,CELF3,SLC8A3,CCDC136,SYT1,L1CAM,CACNA2D1,DLG4,GRIN1,MCF2L2,GABRB2,LRRC7,STX1A,CAMK2A,EPHA6,FGF14,IQSEC2,PPFIA2,NRXN2,SNAP25,HCN1,MYT1L,DNM1,SCN8A
2.435e-02-3.72ZNF785 (zinc finger protein 785)protein interactions1465409421945450 STX1A,CCDC136
2.445e-02-3.71GEDsmart domainsSM0030261971740 DNM1
2.461e-02-3.70myofibrilcellular componentGO:003001623931910850 CACNA1C,SCN8A,RYR2
2.492e-02-3.69NrCAM interactionsREACTOME pathwaysR-HSA-447038711028537 DLG4
2.497e-02-3.69Alzheimers DiseaseWikiPathwaysWP20591483531023 GRIN2B,CACNA1C,GRIN1
2.500e-02-3.69IFN-gamma pathwayPathway Interaction DBifngpathway402222614 CAMK2B,CAMK2A
2.501e-02-3.69CHprosite domainsPS500218121218637 SPTBN2,SPTBN4
2.505e-02-3.69ITSN1 (intersectin 1)protein interactions645324531945450 SNAP25,DNM1,PPFIA2
2.519e-02-3.68regulation of protein transportbiological processGO:005122343341820447 SNAP25,STX1A,VSNL1,CPLX1
2.519e-02-3.68inorganic ion homeostasisbiological processGO:009877143341820447 GRM5,SLC8A3,RYR2,GRIN1
2.525e-02-3.68skin-trunk-malignant_melanoma-nodularCOSMIC cancer mutationsskin-trunk-malignant_melanoma-nodular129181682847 ABLIM1,PPFIA3,GRIN2B,SPTBN2,SPTBN4,SNAP25,CELF5,HCN1
2.532e-02-3.68CAST (calpastatin)protein interactions8319621945450 PPFIA2,PPFIA3
2.532e-02-3.68VAMP8 (vesicle associated membrane protein 8)protein interactions86739621945450 STX1A,SNAP25
2.541e-02-3.67ALKAL2 (ALK and LTK ligand 2)protein interactions2850161011945450 CACNA2D1
2.541e-02-3.67Eps15 (epidermal growth factor receptor pathway substrate 15)protein interactions138581011945450 DNM1
2.541e-02-3.67SCN8A (sodium voltage-gated channel alpha subunit 8)protein interactions63341011945450 FGF14
2.541e-02-3.67RAB37 (RAB37, member RAS oncogene family)protein interactions3266241011945450 RIMS1
2.541e-02-3.67SLC8A2 (solute carrier family 8 member A2)protein interactions65431011945450 SLC8A3
2.541e-02-3.67SDHAF1 (succinate dehydrogenase complex assembly factor 1)protein interactions6440961011945450 CCDC136
2.541e-02-3.67ASIC3 (acid sensing ion channel subunit 3)protein interactions93111011945450 DLG4
2.541e-02-3.67Vbp1 (von Hippel-Lindau binding protein 1)protein interactions223271011945450 ABLIM1
2.543e-02-3.67cellular response to endogenous stimulusbiological processGO:0071495113571820447 RYR2,HCN1,GABRB2,GRIN1,CACNA2D1,CACNA1A,CAMK2A
2.550e-02-3.67astrocytoma_Grade_IICOSMIC cancer mutationsastrocytoma_Grade_II60151682847 CACNA2D1,CACNA1C,CACNA1G,DLGAP2,SPTBN4
2.551e-02-3.67vesicle fusionbiological processGO:00069069621820447 STX1A,SNAP25
2.551e-02-3.67CCDC8 (coiled-coil domain containing 8)protein interactions8398765251945450 CACNA2D1,ABLIM1,IQSEC2,SPTBN2,EDIL3
2.553e-02-3.67trans-synaptic signaling, modulating synaptic transmissionbiological processGO:00995501011820447 GRM5
2.553e-02-3.67response to histaminebiological processGO:00347761011820447 GABRB2
2.553e-02-3.67neurotransmitter receptor transport, endosome to postsynaptic membranebiological processGO:00988871011820447 LRRC7
2.553e-02-3.67release of sequestered calcium ion into cytosol by endoplasmic reticulumbiological processGO:19035141011820447 RYR2
2.553e-02-3.67regulation of atrial cardiac muscle cell membrane depolarizationbiological processGO:00603711011820447 CACNA1G
2.553e-02-3.67regulation of modification of postsynaptic structurebiological processGO:00991591011820447 CAMKV
2.553e-02-3.67synaptic vesicle budding from presynaptic endocytic zone membranebiological processGO:00161851011820447 DNM1
2.553e-02-3.67substrate-independent telencephalic tangential migrationbiological processGO:00218261011820447 NRG3
2.553e-02-3.67learned vocalization behavior or vocal learningbiological processGO:00985981011820447 NRXN2
2.553e-02-3.67substrate-independent telencephalic tangential interneuron migrationbiological processGO:00218431011820447 NRG3
2.553e-02-3.67neurotransmitter receptor transport, endosome to plasma membranebiological processGO:00996391011820447 LRRC7
2.553e-02-3.67postsynaptic membrane assemblybiological processGO:00971041011820447 NRXN2
2.553e-02-3.67regulation of high voltage-gated calcium channel activitybiological processGO:19018411011820447 CACNA2D1
2.553e-02-3.67regulation of postsynaptic cytosolic calcium ion concentrationbiological processGO:00995661011820447 GRM5
2.553e-02-3.67postsynaptic density assemblybiological processGO:00971071011820447 NRXN2
2.553e-02-3.67regulation of voltage-gated sodium channel activitybiological processGO:19051501011820447 FGF14
2.555e-02-3.67positive regulation of neurogenesisbiological processGO:005076924631820447 GRM5,L1CAM,CAMK2B
2.568e-02-3.66SPTAN1 (spectrin alpha, non-erythrocytic 1)protein interactions670943741945450 GRIN1,GRIN2B,SPTBN4,SPTBN2
2.581e-02-3.66LIN7C (lin-7 homolog C, crumbs cell polarity complex component)protein interactions553279721945450 ABLIM1,DLG4
2.583e-02-3.66abdomenCOSMIC cancer mutationsabdomen60351682847 RIMS1,EPHA6,NRXN3,SNAP25,SPTBN4
2.587e-02-3.65postsynaptic cytoskeletoncellular componentGO:00995711011910850 SPTBN2
2.587e-02-3.65neurofilamentcellular componentGO:00058831011910850 DLGAP2
2.594e-02-3.65skin-abdomen-malignant_melanomaCOSMIC cancer mutationsskin-abdomen-malignant_melanoma40441682847 NRXN3,SPTBN4,SNAP25,EPHA6
2.594e-02-3.65intracellular monoatomic ion homeostasisbiological processGO:000687343741820447 GRM5,SLC8A3,RYR2,SLC4A10
2.600e-02-3.65nerve developmentbiological processGO:00216759721820447 SCN8A,GABRB2
2.611e-02-3.65MIRpfam domainsPF028151011779547 RYR2
2.611e-02-3.65Na_trans_assocpfam domainsPF065121011779547 SCN8A
2.611e-02-3.65HCO3_cotransppfam domainsPF009551011779547 SLC4A10
2.615e-02-3.64HCO3_transpt-like_TM_dominterpro domainsIPR0115311011852149 SLC4A10
2.615e-02-3.64MIR_dom_sfinterpro domainsIPR0363001011852149 RYR2
2.615e-02-3.64Na_trans_assoc_dominterpro domainsIPR0105261011852149 SCN8A
2.615e-02-3.64Na_chnl_inactivation_gateinterpro domainsIPR0445641011852149 SCN8A
2.615e-02-3.64MIR_motifinterpro domainsIPR0160931011852149 RYR2
2.615e-02-3.64HCO3_transpt_eukinterpro domainsIPR0030201011852149 SLC4A10
2.615e-02-3.64PTrfase/Anion_transptrinterpro domainsIPR0161521011852149 SLC4A10
2.615e-02-3.64Na_channel_asuinterpro domainsIPR0016961011852149 SCN8A
2.619e-02-3.64EGF-type_Asp/Asn_hydroxyl_siteinterpro domainsIPR0001529521852149 EDIL3,NRXN3
2.624e-02-3.64Guanylate Kinase phosphate binding domaingene3d domains3.30.63.10811447048 DLG4
2.624e-02-3.64Villin headpiece domaingene3d domains1.10.950.10811447048 ABLIM1
2.631e-02-3.64PTK2B (protein tyrosine kinase 2 beta)protein interactions21859821945450 DLG4,DNM1
2.631e-02-3.64GNAO1 (G protein subunit alpha o1)protein interactions27759821945450 SCN8A,CAMK2A
2.631e-02-3.64eyeCOSMIC cancer mutationseye60651682847 PCLO,MYT1L,GRIN2B,CACNA1E,CAMK2B
2.646e-02-3.63human chr9q33.1chromosome locationhuman chr9q33.11412613450 BRINP1
2.649e-02-3.63DYNAMINprints domainsPR0019571522720 DNM1
2.650e-02-3.63organelle membrane fusionbiological processGO:00901749821820447 SNAP25,STX1A
2.662e-02-3.63regulation of anatomical structure morphogenesisbiological processGO:002260389461820447 CAMK2B,RIMS1,SYT1,PPFIA2,L1CAM,DLG4
2.676e-02-3.62calcium:sodium antiporter activitymolecular functionGO:00054321011809449 SLC8A3
2.676e-02-3.62calcium-dependent protein kinase activitymolecular functionGO:00108571011809449 CAMK2B
2.676e-02-3.62profilin bindingmolecular functionGO:00055221011809449 PCLO
2.680e-02-3.62EFNA1 (ephrin A1)protein interactions19429921945450 VSNL1,EPHA6
2.688e-02-3.62Neuroactive ligand-receptor interactionKEGG pathwayshsa040802764716130 GRIN1,GABRB2,GRIN2B,GRM5
2.688e-02-3.62Neuroactive ligand-receptor interactionKEGG pathwaysko040802764716130 GRIN2B,GRM5,GABRB2,GRIN1
2.691e-02-3.62Immune SystemREACTOME pathwaysR-HSA-1682562101131028537 CAMK2A,GRIN2B,STX1A,DNM1,RASGRF1,LRRC7,SPTBN2,SPTBN4,NRG3,GRIN1,SNAP25,CAMK2B,DLG4
2.701e-02-3.61regulation of signaling receptor activitybiological processGO:00104699921820447 DLGAP2,DLG4
2.701e-02-3.61G_PROTEIN_RECEP_F3_1prosite domainsPS00979911218637 GRM5
2.701e-02-3.61soft_tissue-striated_muscle-rhabdomyosarcoma-embryonalCOSMIC cancer mutationssoft_tissue-striated_muscle-rhabdomyosarcoma-embryonal2659131682847 PCLO,DLG4,MCF2L2,RIMS1,CACNA1A,RYR2,CACNA1E,SPTBN4,MYT1L,NRXN2,PPFIA2,DLGAP2,EPHA6
2.701e-02-3.61embryonalCOSMIC cancer mutationsembryonal2659131682847 PPFIA2,NRXN2,DLGAP2,EPHA6,CACNA1A,RIMS1,MCF2L2,DLG4,PCLO,SPTBN4,CACNA1E,RYR2,MYT1L
2.712e-02-3.61EF-hand_7pfam domainsPF134999721779547 RYR2,VSNL1
2.715e-02-3.61mesotheliomaCOSMIC cancer mutationsmesothelioma4477191682847 L1CAM,RYR2,CAMKV,CACNA1E,SYT1,PCLO,PPFIA3,RASGRF1,MCF2L2,DNM1,EPHA6,SLC4A10,EDIL3,CAMK2A,CAMK2B,NRXN2,GRIN2B,IQSEC2,PPFIA2
2.721e-02-3.60STX5 (syntaxin 5)protein interactions681125331945450 STX1A,SNAP25,TMEM266
2.734e-02-3.60contractile muscle fibercellular componentGO:004329224931910850 CACNA1C,RYR2,SCN8A
2.781e-02-3.58oesophagusCOSMIC cancer mutationsoesophagus14970461682847 SLC8A3,CCDC136,CPLX1,CAMK2B,SLC4A10,EDIL3,CACNA1C,SPTBN2,CELF3,CACNA2D1,DLG4,MCF2L2,GRIN1,SYT1,L1CAM,IQSEC2,FGF14,PPFIA2,NRXN2,LRRC7,GABRB2,STX1A,CAMK2A,EPHA6,SCN8A,SNAP25,HCN1,MYT1L,GRIN2B,NRG3,VSNL1,GRM5,NRXN3,CACNA1A,RIMS1,PCLO,RASGRF1,CACNA1E,RYR2,CACNA1G,ABLIM1,DLGAP2,CELF5,PPFIA3,SPTBN4,CAMKV
2.783e-02-3.58myelofibrosisCOSMIC cancer mutationsmyelofibrosis41341682847 MCF2L2,RIMS1,GRIN2B,CACNA1E
2.783e-02-3.58haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosisCOSMIC cancer mutationshaematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosis41341682847 GRIN2B,CACNA1E,RIMS1,MCF2L2
2.792e-02-3.58SV2C (synaptic vesicle glycoprotein 2C)protein interactions229871111945450 SYT1
2.792e-02-3.58CELF3 (CUGBP Elav-like family member 3)protein interactions111891111945450 CELF5
2.792e-02-3.58PLA2G5 (phospholipase A2 group V)protein interactions53221111945450 CACNA2D1
2.792e-02-3.58ZNF230 (zinc finger protein 230)protein interactions77731111945450 CCDC136
2.792e-02-3.58RIMS3 (regulating synaptic membrane exocytosis 3)protein interactions97831111945450 RIMS1
2.792e-02-3.58PIP5K1P1 (phosphatidylinositol-4-phosphate 5-kinase type 1 pseudogene 1)protein interactions2064261111945450 NRXN3
2.792e-02-3.58Katna1 (katanin p60 (ATPase-containing) subunit A1)protein interactions239241111945450 RIMS1
2.792e-02-3.58Fcho2 (FCH domain only 2)protein interactions2185031111945450 DNM1
2.792e-02-3.58DUS4L (dihydrouridine synthase 4 like)protein interactions110621111945450 CAMK2B
2.795e-02-3.58lipid bindingmolecular functionGO:000828986161809449 DNM1,SPTBN4,SPTBN2,SNAP25,SYT1,PCLO
2.804e-02-3.57ectodermal placode formationbiological processGO:00607881111820447 NRG3
2.804e-02-3.57negative regulation of neuron migrationbiological processGO:20012231111820447 NRG3
2.804e-02-3.57short-term memorybiological processGO:00076141111820447 BRINP1
2.804e-02-3.57synaptic vesicle buddingbiological processGO:00701421111820447 DNM1
2.804e-02-3.57cellular response to epinephrine stimulusbiological processGO:00718721111820447 RYR2
2.804e-02-3.57pyramidal neuron developmentbiological processGO:00218601111820447 SLC4A10
2.804e-02-3.57retinal cone cell developmentbiological processGO:00465491111820447 HCN1
2.804e-02-3.57ectodermal placode morphogenesisbiological processGO:00716971111820447 NRG3
2.804e-02-3.57cellular response to caffeinebiological processGO:00713131111820447 RYR2
2.804e-02-3.57regulation of membrane repolarization during action potentialbiological processGO:00989031111820447 CACNA2D1
2.804e-02-3.57regulation of neurotransmitter receptor localization to postsynaptic specialization membranebiological processGO:00986961111820447 IQSEC2
2.804e-02-3.57synaptic vesicle clusteringbiological processGO:00970911111820447 PCLO
2.822e-02-3.57extrinsic component of plasma membranecellular componentGO:001989710021910850 DLG4,SNAP25
2.823e-02-3.57-gene3d domains2.80.10.507921447048 RYR2,FGF14
2.823e-02-3.57Calponin-like domaingene3d domains1.10.418.107921447048 SPTBN4,SPTBN2
2.832e-02-3.56human chr12q21.2chromosome locationhuman chr12q21.21512613450 SYT1
2.832e-02-3.56KRTAP6-1 (keratin associated protein 6-1)protein interactions33796610221945450 CELF5,CAMK2A
2.832e-02-3.56PATJ (PATJ crumbs cell polarity complex component)protein interactions1020710221945450 GRIN2B,NRXN2
2.842e-02-3.56microvesiclecellular componentGO:19907421111910850 PPFIA3
2.847e-02-3.56DYNcsmart domainsSM0005371971740 DNM1
2.858e-02-3.55regulation of hormone secretionbiological processGO:004688325731820447 VSNL1,STX1A,SNAP25
2.868e-02-3.55MACPFpfam domainsPF018231111779547 BRINP1
2.873e-02-3.55Syntaxin_Ninterpro domainsIPR0060111111852149 STX1A
2.884e-02-3.55CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2)protein interactions5545410321945450 SLC8A3,SYT1
2.884e-02-3.55C1orf94 (chromosome 1 open reading frame 94)protein interactions8497010321945450 CAMK2A,RIMS1
2.892e-02-3.54Gliclazide Action PathwaySMPDB pathwaysSMP00004615113698 CACNA1A
2.892e-02-3.54Repaglinide Action PathwaySMPDB pathwaysSMP00004545113698 CACNA1A
2.892e-02-3.54Pancreas FunctionSMPDB pathwaysSMP00006435113698 CACNA1A
2.892e-02-3.54Nateglinide Action PathwaySMPDB pathwaysSMP00004535113698 CACNA1A
2.892e-02-3.54Glibenclamide Action PathwaySMPDB pathwaysSMP00004605113698 CACNA1A
2.899e-02-3.54MECP2 and Associated Rett SyndromeWikiPathwaysWP3584622531023 CAMK2A,GRIN1
2.913e-02-3.54GliomaKEGG pathwayshsa05214642716130 CAMK2A,CAMK2B
2.913e-02-3.54GliomaKEGG pathwaysko05214642716130 CAMK2B,CAMK2A
2.913e-02-3.54bone-femur-chondrosarcomaCOSMIC cancer mutationsbone-femur-chondrosarcoma41941682847 HCN1,CACNA1E,DLGAP2,LRRC7
2.936e-02-3.53RRP7A (ribosomal RNA processing 7 homolog A)protein interactions2734110421945450 SYT1,CAMK2A
2.936e-02-3.53HUNK (hormonally up-regulated Neu-associated kinase)protein interactions3081110421945450 VSNL1,ABLIM1
2.940e-02-3.53axon guidance receptor activitymolecular functionGO:00080461111809449 L1CAM
2.940e-02-3.53cyclic nucleotide-activated monoatomic ion channel activitymolecular functionGO:00438551111809449 HCN1
2.940e-02-3.53intracellularly cyclic nucleotide-activated monoatomic cation channel activitymolecular functionGO:00052211111809449 HCN1
2.940e-02-3.53acetylcholine receptor bindingmolecular functionGO:00331301111809449 DLG4
2.947e-02-3.52NCX, central ion-binding regiongene3d domains1.20.1420.30911447048 SLC8A3
2.947e-02-3.52-gene3d domains2.60.40.2030911447048 SLC8A3
2.950e-02-3.52voltage-gated potassium channel activitymolecular functionGO:00052499921809449 SNAP25,HCN1
2.952e-02-3.52anchoring junctioncellular componentGO:007016190261910850 SPTBN2,LRRC7,SLC8A3,SPTBN4,L1CAM,DLG4
2.958e-02-3.52Myometrial Relaxation and Contraction PathwaysWikiPathwaysWP2891583531023 RYR2,CAMK2A,CAMK2B
2.962e-02-3.52actin bindingmolecular functionGO:000377943441809449 SPTBN4,SPTBN2,ABLIM1,CAMK2B
2.964e-02-3.52basolateral plasma membranecellular componentGO:001632325731910850 SLC4A10,LRRC7,DLG4
2.985e-02-3.51large_cell_carcinomaCOSMIC cancer mutationslarge_cell_carcinoma84961682847 NRXN3,EPHA6,CAMK2A,CAMKV,CAMK2B,SYT1
2.985e-02-3.51lung-carcinoma-large_cell_carcinomaCOSMIC cancer mutationslung-carcinoma-large_cell_carcinoma84961682847 NRXN3,CAMKV,CAMK2A,CAMK2B,SYT1,EPHA6
2.988e-02-3.51CEP72 (centrosomal protein 72)protein interactions5572210521945450 PCLO,SLC4A10
2.996e-02-3.51MIRprosite domainsPS509191011218637 RYR2
3.003e-02-3.51CHsmart domainsSM00033662971740 SPTBN4,SPTBN2
3.005e-02-3.50amino acid transmembrane transporter activitymolecular functionGO:001517110021809449 GRIN2B,GRIN1
3.018e-02-3.50human chr20p12.2chromosome locationhuman chr20p12.21612613450 SNAP25
3.022e-02-3.50MTABOTROPICRprints domainsPR0059381522720 GRM5
3.025e-02-3.50oesophagus-upper_third-carcinoma-squamous_cell_carcinomaCOSMIC cancer mutationsoesophagus-upper_third-carcinoma-squamous_cell_carcinoma62951682847 PCLO,RYR2,SLC4A10,LRRC7,CACNA1E
3.025e-02-3.50upper_thirdCOSMIC cancer mutationsupper_third62951682847 CACNA1E,LRRC7,RYR2,SLC4A10,PCLO
3.040e-02-3.49CWC22 (CWC22 spliceosome associated protein homolog)protein interactions5770310621945450 SYT1,CAMKV
3.042e-02-3.49ZNF843 (zinc finger protein 843)protein interactions2839331211945450 CAMK2B
3.042e-02-3.49MATN3 (matrilin 3)protein interactions41481211945450 EDIL3
3.042e-02-3.49PDC (phosducin)protein interactions51321211945450 CAMK2A
3.042e-02-3.49VSTM4 (V-set and transmembrane domain containing 4)protein interactions1967401211945450 STX1A
3.042e-02-3.49MATCAP2 (microtubule associated tyrosine carboxypeptidase 2)protein interactions233661211945450 CAMK2A
3.048e-02-3.49protein-containing complexcellular componentGO:00329916542241910850 GABRB2,CELF3,CPLX1,HCN1,CACNA1G,CACNA1C,DLG4,NRXN2,SPTBN4,CACNA1E,CAMK2A,SCN8A,CACNA1A,SPTBN2,SNAP25,CELF5,RYR2,CAMK2B,DNM1,GRIN1,GRIN2B,CACNA2D1,STX1A,MYT1L
3.056e-02-3.49negative regulation of heart ratebiological processGO:00104591211820447 SPTBN4
3.056e-02-3.49maternal behaviorbiological processGO:00427111211820447 BRINP1
3.056e-02-3.49neuronal ion channel clusteringbiological processGO:00451611211820447 SPTBN4
3.056e-02-3.49SNARE complex assemblybiological processGO:00354931211820447 SNAP25
3.056e-02-3.49auditory behaviorbiological processGO:00312231211820447 NRXN2
3.056e-02-3.49sinoatrial node developmentbiological processGO:00031631211820447 CACNA1G
3.056e-02-3.49neurotransmitter-gated ion channel clusteringbiological processGO:00725781211820447 DLG4
3.091e-02-3.48regulation of protein secretionbiological processGO:005070826531820447 STX1A,SNAP25,VSNL1
3.093e-02-3.48Alzheimer's diseaseKEGG pathwayshsa050101653716130 GRIN1,GRIN2B,CACNA1C
3.093e-02-3.48Alzheimer's diseaseKEGG pathwaysko050101653716130 CACNA1C,GRIN1,GRIN2B
3.093e-02-3.48APLP2 (amyloid beta precursor like protein 2)protein interactions33410721945450 GRIN2B,GRIN1
3.096e-02-3.48paranode region of axoncellular componentGO:00332701211910850 SPTBN4
3.096e-02-3.48clathrin-sculpted vesiclecellular componentGO:00601981211910850 SYT1
3.130e-02-3.46MACPFinterpro domainsIPR0208641211852149 BRINP1
3.130e-02-3.46Rab_BDinterpro domainsIPR0109111211852149 RIMS1
3.130e-02-3.46K_chnl_volt-dep_EAG/ELK/ERGinterpro domainsIPR0039381211852149 HCN1
3.148e-02-3.46striated_muscleCOSMIC cancer mutationsstriated_muscle4228181682847 RIMS1,CACNA1A,DLG4,MCF2L2,PCLO,SPTBN4,CACNA1E,HCN1,RYR2,MYT1L,PPFIA2,NRXN2,LRRC7,GABRB2,DLGAP2,CACNA1C,SPTBN2,EPHA6
3.155e-02-3.46Sudden Infant Death Syndrome (SIDS) Susceptibility PathwaysWikiPathwaysWP7061623531023 RYR2,SNAP25,GRIN1
3.162e-02-3.45kidney-carcinoma-chromophobe_renal_cell_carcinomaCOSMIC cancer mutationskidney-carcinoma-chromophobe_renal_cell_carcinoma43041682847 EPHA6,CAMK2B,CAMK2A,CAMKV
3.162e-02-3.45chromophobe_renal_cell_carcinomaCOSMIC cancer mutationschromophobe_renal_cell_carcinoma43041682847 EPHA6,CAMKV,CAMK2A,CAMK2B
3.173e-02-3.45RhoGEFsmart domainsSM00325682971740 MCF2L2,RASGRF1
3.178e-02-3.45eye-uveal_tract-malignant_melanoma-mixedCOSMIC cancer mutationseye-uveal_tract-malignant_melanoma-mixed10021682847 MYT1L,CAMK2B
3.193e-02-3.44Formation of annular gap junctionsREACTOME pathwaysR-HSA-196025911028537 DNM1
3.203e-02-3.44bicarbonate:monoatomic anion antiporter activitymolecular functionGO:01408291211809449 SLC4A10
3.203e-02-3.44calcium channel inhibitor activitymolecular functionGO:00198551211809449 STX1A
3.203e-02-3.44chloride:bicarbonate antiporter activitymolecular functionGO:01409001211809449 SLC4A10
3.221e-02-3.44Transmembrane transport of small moleculesREACTOME pathwaysR-HSA-38255167761028537 CAMK2B,SLC4A10,GABRB2,RYR2,SLC8A3,CAMK2A
3.239e-02-3.43breast-carcinoma-ER-PR-positive_carcinomaCOSMIC cancer mutationsbreast-carcinoma-ER-PR-positive_carcinoma1881101682847 NRG3,FGF14,RASGRF1,CACNA1A,GRM5,RYR2,CACNA1E,LRRC7,EPHA6,MYT1L
3.239e-02-3.43ER-PR-positive_carcinomaCOSMIC cancer mutationsER-PR-positive_carcinoma1881101682847 EPHA6,MYT1L,CACNA1E,LRRC7,RYR2,CACNA1A,GRM5,RASGRF1,FGF14,NRG3
3.247e-02-3.43VHPsmart domainsSM0015381971740 ABLIM1
3.247e-02-3.43Calx_betasmart domainsSM0023781971740 SLC8A3
3.254e-02-3.43breast-carcinomaCOSMIC cancer mutationsbreast-carcinoma15030461682847 CELF3,SPTBN2,EDIL3,CACNA1C,SLC4A10,CAMK2B,CCDC136,SLC8A3,L1CAM,SYT1,GRIN1,DLG4,MCF2L2,CACNA2D1,EPHA6,CAMK2A,STX1A,LRRC7,GABRB2,NRXN2,PPFIA2,FGF14,IQSEC2,MYT1L,HCN1,SNAP25,SCN8A,DNM1,GRM5,VSNL1,NRG3,GRIN2B,RYR2,CACNA1E,RASGRF1,PCLO,CACNA1A,RIMS1,NRXN3,CELF5,DLGAP2,ABLIM1,CACNA1G,CAMKV,SPTBN4,PPFIA3
3.262e-02-3.42COPI-mediated anterograde transportREACTOME pathwaysR-HSA-68078787921028537 SPTBN2,SPTBN4
3.263e-02-3.42peptide bindingmolecular functionGO:004227725831809449 GRIN1,GRIN2B,CACNA1A
3.269e-02-3.42Helix hairpin bingene3d domains1.10.287.6301011447048 HCN1
3.269e-02-3.42Helical hairpin bingene3d domains1.10.287.5701011447048 SLC4A10
3.291e-02-3.41G_PROTEIN_RECEP_F3_3prosite domainsPS009811111218637 GRM5
3.291e-02-3.41IGLC6 (immunoglobulin lambda constant 6)protein interactions35421311945450 HCN1
3.291e-02-3.41PCAT1 (prostate cancer associated transcript 1)protein interactions1007502251311945450 PCLO
3.291e-02-3.41NCAN (neurocan)protein interactions14631311945450 L1CAM
3.291e-02-3.41SNPH (syntaphilin)protein interactions97511311945450 STX1A
3.291e-02-3.41CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4)protein interactions7851311945450 CACNA1A
3.306e-02-3.41regulation of translational elongationbiological processGO:00064481311820447 GRM5
3.306e-02-3.41regulation of dendritic spine maintenancebiological processGO:19029501311820447 GRIN2B
3.306e-02-3.41postsynaptic specialization assemblybiological processGO:00986981311820447 NRXN2
3.306e-02-3.41regulation of norepinephrine secretionbiological processGO:00140611311820447 STX1A
3.306e-02-3.41positive regulation of calcium ion transport into cytosolbiological processGO:00105241311820447 GRIN1
3.306e-02-3.41parental behaviorbiological processGO:00607461311820447 BRINP1
3.306e-02-3.41retinal cone cell differentiationbiological processGO:00426701311820447 HCN1
3.306e-02-3.41cellular response to potassium ionbiological processGO:00358651311820447 DLG4
3.306e-02-3.41ectodermal placode developmentbiological processGO:00716961311820447 NRG3
3.333e-02-3.40regulation of mRNA splicing, via spliceosomebiological processGO:004802411121820447 CELF5,CELF3
3.333e-02-3.40positive regulation of peptide hormone secretionbiological processGO:009027711121820447 SNAP25,VSNL1
3.363e-02-3.39VAMP7 (vesicle associated membrane protein 7)protein interactions684511221945450 SNAP25,STX1A
3.363e-02-3.39ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)protein interactions370911221945450 CAMK2A,CAMK2B
3.375e-02-3.39stomach-carcinomaCOSMIC cancer mutationsstomach-carcinoma43941682847 EPHA6,CAMKV,CAMK2A,CAMK2B
3.381e-02-3.39NCD3Gpfam domainsPF075621311779547 GRM5
3.381e-02-3.39SNAREpfam domainsPF057391311779547 STX1A
3.386e-02-3.39GPCR_3_9-Cys_sfinterpro domainsIPR0385501311852149 GRM5
3.386e-02-3.39GPCR_3_9-Cys_dominterpro domainsIPR0115001311852149 GRM5
3.389e-02-3.38human chr13q33.1chromosome locationhuman chr13q33.11812613450 FGF14
3.389e-02-3.38human chr8p23.3chromosome locationhuman chr8p23.31812613450 DLGAP2
3.418e-02-3.38GFI1B (growth factor independent 1B transcriptional repressor)protein interactions832811321945450 VSNL1,CCDC136
3.425e-02-3.37ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)protein interactions2339027731945450 DLG4,SYT1,SNAP25
3.444e-02-3.37positive regulation of peptide secretionbiological processGO:000279311321820447 VSNL1,SNAP25
3.444e-02-3.37dendrite developmentbiological processGO:001635811321820447 DLG4,CAMK2A
3.460e-02-3.36phosphatidylinositol bisphosphate bindingmolecular functionGO:190293610821809449 SYT1,DNM1
3.465e-02-3.36monoatomic cation:bicarbonate symporter activitymolecular functionGO:01404101311809449 SLC4A10
3.465e-02-3.36chloride channel regulator activitymolecular functionGO:00170811311809449 STX1A
3.465e-02-3.36calcium:monoatomic cation antiporter activitymolecular functionGO:00153681311809449 SLC8A3
3.465e-02-3.36GABA-gated chloride ion channel activitymolecular functionGO:00228511311809449 GABRB2
3.474e-02-3.36ITPRID2 (ITPR interacting domain containing 2)protein interactions674411421945450 CAMK2A,CAMK2B
3.475e-02-3.36central_nervous_system-cerebellum-glioma-astrocytoma_Grade_ICOSMIC cancer mutationscentral_nervous_system-cerebellum-glioma-astrocytoma_Grade_I10521682847 NRG3,FGF14
3.507e-02-3.35adenoid_cystic_carcinomaCOSMIC cancer mutationsadenoid_cystic_carcinoma112371682847 GRIN2B,RYR2,SLC4A10,CACNA1C,LRRC7,CACNA1E,L1CAM
3.530e-02-3.34CDH2 (cadherin 2)protein interactions100011521945450 LRRC7,GRIN1
3.540e-02-3.34TMEM41A (transmembrane protein 41A)protein interactions904071411945450 STX1A
3.540e-02-3.34KRTAP22-1 (keratin associated protein 22-1)protein interactions3379791411945450 CAMK2A
3.540e-02-3.34TIMD4 (T cell immunoglobulin and mucin domain containing 4)protein interactions919371411945450 SPTBN4
3.540e-02-3.34Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)protein interactions131961411945450 DNM1
3.540e-02-3.34SYT5 (synaptotagmin 5)protein interactions68611411945450 SYT1
3.540e-02-3.34KCNC1 (potassium voltage-gated channel subfamily C member 1)protein interactions37461411945450 CAMK2A
3.540e-02-3.34CHAT (choline O-acetyltransferase)protein interactions11031411945450 CAMK2A
3.540e-02-3.34CHGA (chromogranin A)protein interactions11131411945450 SYT1
3.540e-02-3.34Pkm (pyruvate kinase, muscle)protein interactions187461411945450 BRINP1
3.540e-02-3.34GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2)protein interactions29771411945450 DLG4
3.540e-02-3.34C20orf96 (chromosome 20 open reading frame 96)protein interactions1406801411945450 CAMK2B
3.540e-02-3.34SLC38A6 (solute carrier family 38 member 6)protein interactions1453891411945450 EDIL3
3.541e-02-3.34Bicarbonate transportersREACTOME pathwaysR-HSA-4253811011028537 SLC4A10
3.541e-02-3.34Gap junction degradationREACTOME pathwaysR-HSA-1908731011028537 DNM1
3.541e-02-3.34PI3K events in ERBB4 signalingREACTOME pathwaysR-HSA-12503421011028537 NRG3
3.556e-02-3.34regulation of skeletal muscle adaptationbiological processGO:00147331411820447 CAMK2B
3.556e-02-3.34mechanosensory behaviorbiological processGO:00076381411820447 NRXN2
3.556e-02-3.34neurotransmitter receptor localization to postsynaptic specialization membranebiological processGO:00996451411820447 DLG4
3.556e-02-3.34protein localization to endosomebiological processGO:00360101411820447 LRRC7
3.556e-02-3.34atrial cardiac muscle cell to AV node cell signalingbiological processGO:00860261411820447 CACNA1C
3.556e-02-3.34synaptic vesicle primingbiological processGO:00160821411820447 SNAP25
3.556e-02-3.34regulation of NMDA receptor activitybiological processGO:20003101411820447 DLG4
3.556e-02-3.34protein localization to postsynaptic specialization membranebiological processGO:00996331411820447 DLG4
3.556e-02-3.34G protein-coupled glutamate receptor signaling pathwaybiological processGO:00072161411820447 GRM5
3.556e-02-3.34response to epinephrinebiological processGO:00718711411820447 RYR2
3.556e-02-3.34regulation of modification of synaptic structurebiological processGO:19052441411820447 CAMKV
3.556e-02-3.34atrial cardiac muscle cell action potentialbiological processGO:00860141411820447 CACNA1C
3.556e-02-3.34regulation of long-term synaptic depressionbiological processGO:19004521411820447 IQSEC2
3.556e-02-3.34bundle of His cell to Purkinje myocyte communicationbiological processGO:00860691411820447 CACNA2D1
3.556e-02-3.34response to redox statebiological processGO:00517751411820447 RYR2
3.556e-02-3.34cellular response to purine-containing compoundbiological processGO:00714151411820447 RYR2
3.578e-02-3.33structural constituent of cytoskeletonmolecular functionGO:000520011021809449 SPTBN2,SPTBN4
3.585e-02-3.33RABBDprosite domainsPS509161211218637 RIMS1
3.586e-02-3.33KRTAP19-7 (keratin associated protein 19-7)protein interactions33797411621945450 CAMK2A,CAMK2B
3.590e-02-3.33-gene3d domains1.10.220.201111447048 IQSEC2
3.592e-02-3.33organic anion transmembrane transporter activitymolecular functionGO:000851426831809449 GRIN2B,GRIN1,SLC4A10
3.592e-02-3.33PRKACA (protein kinase cAMP-activated catalytic subunit alpha)protein interactions556648641945450 RYR2,SNAP25,CACNA1C,RASGRF1
3.595e-02-3.33endometrium-carcinoma-endometrioid_carcinomaCOSMIC cancer mutationsendometrium-carcinoma-endometrioid_carcinoma15680471682847 L1CAM,SYT1,GRIN1,DLG4,MCF2L2,CACNA2D1,SPTBN2,CELF3,CAMK2B,CPLX1,EDIL3,CACNA1C,SLC4A10,CCDC136,SLC8A3,MYT1L,SNAP25,HCN1,SCN8A,DNM1,EPHA6,LRRC7,GABRB2,STX1A,CAMK2A,PPFIA2,IQSEC2,FGF14,NRXN2,CACNA1E,RYR2,CACNA1A,RIMS1,RASGRF1,PCLO,NRXN3,GRM5,VSNL1,GRIN2B,NRG3,SPTBN4,CAMKV,PPFIA3,DLGAP2,CELF5,ABLIM1,CACNA1G
3.603e-02-3.32extrinsic component of synaptic membranecellular componentGO:00992431411910850 SNAP25
3.603e-02-3.32voltage-gated sodium channel complexcellular componentGO:00015181411910850 SCN8A
3.612e-02-3.32regulation of cation channel activitybiological processGO:200125711621820447 CACNA2D1,FGF14
3.635e-02-3.31YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)protein interactions752996561945450 RASGRF1,ABLIM1,CAMK2B,SLC8A3,IQSEC2,CAMK2A
3.636e-02-3.31Ephrin_lbdpfam domainsPF014041411779547 EPHA6
3.636e-02-3.31EphA2_TMpfam domainsPF145751411779547 EPHA6
3.636e-02-3.31Ephrin_rec_likepfam domainsPF076991411779547 EPHA6
3.642e-02-3.31Eph_TMinterpro domainsIPR0279361411852149 EPHA6
3.642e-02-3.31Tyr_kinase_rcpt_V_CSinterpro domainsIPR0014261411852149 EPHA6
3.642e-02-3.31Tyr_kinase_ephrin_rcptinterpro domainsIPR0162571411852149 EPHA6
3.642e-02-3.31Ras_G-nucl-exch_fac_CSinterpro domainsIPR0198041411852149 RASGRF1
3.642e-02-3.31GPCR_3interpro domainsIPR0003371411852149 GRM5
3.642e-02-3.31GPCR_3_CSinterpro domainsIPR0179791411852149 GRM5
3.642e-02-3.31Tyr-kin_ephrin_A/B_rcpt-likeinterpro domainsIPR0116411411852149 EPHA6
3.642e-02-3.31Ephrin_rcpt_lig-bd_dominterpro domainsIPR0010901411852149 EPHA6
3.642e-02-3.31G_DYNAMIN_dominterpro domainsIPR0303811411852149 DNM1
3.642e-02-3.31Recoverininterpro domainsIPR0288461411852149 VSNL1
3.642e-02-3.31EFEMP1 (EGF containing fibulin extracellular matrix protein 1)protein interactions220211721945450 CACNA1C,CACNA1A
3.646e-02-3.31SynNsmart domainsSM0050391971740 STX1A
3.651e-02-3.31macromolecule localizationbiological processGO:00330362376111820447 SNAP25,RIMS1,CPLX1,NRXN2,SPTBN4,DLG4,PCLO,RYR2,LRRC7,STX1A,HCN1
3.669e-02-3.31regulation of synapse assemblybiological processGO:005196311721820447 IQSEC2,SNAP25
3.686e-02-3.30ASX_HYDROXYLprosite domainsPS0001010021218637 NRXN3,EDIL3
3.704e-02-3.30endometrioid_carcinomaCOSMIC cancer mutationsendometrioid_carcinoma15690471682847 GRIN2B,NRG3,VSNL1,GRM5,CACNA1E,RYR2,NRXN3,RIMS1,CACNA1A,PCLO,RASGRF1,DLGAP2,CELF5,CACNA1G,ABLIM1,SPTBN4,CAMKV,PPFIA3,CPLX1,CAMK2B,EDIL3,CACNA1C,SLC4A10,SPTBN2,CELF3,SLC8A3,CCDC136,SYT1,L1CAM,CACNA2D1,GRIN1,DLG4,MCF2L2,STX1A,LRRC7,GABRB2,CAMK2A,EPHA6,IQSEC2,FGF14,PPFIA2,NRXN2,SNAP25,HCN1,MYT1L,DNM1,SCN8A
3.727e-02-3.29dopamine receptor bindingmolecular functionGO:00507801411809449 DLG4
3.727e-02-3.29protein kinase A catalytic subunit bindingmolecular functionGO:00342361411809449 RYR2
3.727e-02-3.29endometriumCOSMIC cancer mutationsendometrium15692471682847 SPTBN4,CAMKV,PPFIA3,DLGAP2,CELF5,CACNA1G,ABLIM1,CACNA1E,RYR2,NRXN3,CACNA1A,RIMS1,PCLO,RASGRF1,GRIN2B,NRG3,VSNL1,GRM5,SNAP25,HCN1,MYT1L,DNM1,SCN8A,STX1A,LRRC7,GABRB2,CAMK2A,EPHA6,FGF14,IQSEC2,PPFIA2,NRXN2,SYT1,L1CAM,CACNA2D1,MCF2L2,GRIN1,DLG4,CPLX1,CAMK2B,EDIL3,CACNA1C,SLC4A10,SPTBN2,CELF3,SLC8A3,CCDC136
3.745e-02-3.28salivary_glandCOSMIC cancer mutationssalivary_gland113971682847 CACNA1C,SLC4A10,RYR2,CACNA1E,LRRC7,L1CAM,GRIN2B
3.759e-02-3.28human chr12p13.1chromosome locationhuman chr12p13.12012613450 GRIN2B
3.764e-02-3.28HCO3TRNSPORTprints domainsPR01231101522720 SLC4A10
3.764e-02-3.28NACHANNELprints domainsPR00170101522720 SCN8A
3.766e-02-3.28kidney-other-neoplasmCOSMIC cancer mutationskidney-other-neoplasm10653361682847 SYT1,RYR2,CACNA2D1,NRXN3,RIMS1,PCLO,RASGRF1,DLG4,MCF2L2,GRIN1,CPLX1,CAMK2B,CACNA1C,EDIL3,SPTBN2,CELF3,GRIN2B,NRG3,SLC8A3,VSNL1,CCDC136,SNAP25,SPTBN4,HCN1,MYT1L,PPFIA3,SCN8A,DLGAP2,GABRB2,LRRC7,CELF5,CAMK2A,FGF14,PPFIA2,NRXN2,ABLIM1
3.776e-02-3.28Prot_kinase_dominterpro domainsIPR00071948041852149 CAMK2A,CAMKV,EPHA6,CAMK2B
3.788e-02-3.27Cep85l (centrosomal protein 85-like)protein interactions1000387251511945450 BRINP1
3.788e-02-3.27ADGRB2 (adhesion G protein-coupled receptor B2)protein interactions5761511945450 DLG4
3.788e-02-3.27ASCL4 (achaete-scute family bHLH transcription factor 4)protein interactions1215491511945450 DNM1
3.788e-02-3.27Sgo1 (shugoshin 1)protein interactions724151511945450 RIMS1
3.788e-02-3.27RGS9 (regulator of G protein signaling 9)protein interactions87871511945450 GRIN1
3.788e-02-3.27PRR16 (proline rich 16)protein interactions513341511945450 DLG4
3.788e-02-3.27BSN (bassoon presynaptic cytomatrix protein)protein interactions89271511945450 RIMS1
3.788e-02-3.27GPR88 (G protein-coupled receptor 88)protein interactions541121511945450 GRIN1
3.788e-02-3.27DEFB123 (defensin beta 123)protein interactions2459361511945450 CACNA2D1
3.788e-02-3.27FZD1 (frizzled class receptor 1)protein interactions83211511945450 DLG4
3.788e-02-3.27MEGF6 (multiple EGF like domains 6)protein interactions19531511945450 CACNA1A
3.788e-02-3.27AARD (alanine and arginine rich domain containing protein)protein interactions4413761511945450 STX1A
3.799e-02-3.27ovary-carcinoma-mucinous_carcinomaCOSMIC cancer mutationsovary-carcinoma-mucinous_carcinoma45641682847 CAMK2B,CAMK2A,CAMKV,EPHA6
3.802e-02-3.27large_intestine-adenomaCOSMIC cancer mutationslarge_intestine-adenoma26631682847 CACNA1E,SLC4A10,PCLO
3.805e-02-3.27neurotransmitter receptor internalizationbiological processGO:00995901511820447 SNAP25
3.805e-02-3.27pyramidal neuron differentiationbiological processGO:00218591511820447 SLC4A10
3.805e-02-3.27endosome to plasma membrane protein transportbiological processGO:00996381511820447 LRRC7
3.805e-02-3.27atrial cardiac muscle cell to AV node cell communicationbiological processGO:00860661511820447 CACNA1C
3.805e-02-3.27sarcoplasmic reticulum calcium ion transportbiological processGO:00702961511820447 RYR2
3.805e-02-3.27regulation of neuron projection arborizationbiological processGO:01500111511820447 DLG4
3.805e-02-3.27response to caffeinebiological processGO:00310001511820447 RYR2
3.805e-02-3.27apical protein localizationbiological processGO:00451761511820447 HCN1
3.814e-02-3.27ELP3 (elongator acetyltransferase complex subunit 3)protein interactions5514012021945450 CAMK2A,CAMK2B
3.830e-02-3.26positive regulation of cellular processbiological processGO:00485225719211820447 RYR2,LRRC7,CAMK2B,GRIN1,STX1A,IQSEC2,L1CAM,VSNL1,CAMK2A,EDIL3,GRM5,RASGRF1,SYT1,SNAP25,RIMS1,GRIN2B,DLG4,BRINP1,SLC8A3,CACNA2D1,CELF3
3.851e-02-3.26mucinous_carcinomaCOSMIC cancer mutationsmucinous_carcinoma45841682847 EPHA6,CAMK2B,CAMK2A,CAMKV
3.855e-02-3.26BLOC-1 complexcellular componentGO:00310831511910850 SNAP25
3.872e-02-3.25HASPIN (histone H3 associated protein kinase)protein interactions8390312121945450 CACNA2D1,SPTBN2
3.878e-02-3.25G_PROTEIN_RECEP_F3_2prosite domainsPS009801311218637 GRM5
3.891e-02-3.25Dynamin_Npfam domainsPF003501511779547 DNM1
3.891e-02-3.25CRAL_TRIO_2pfam domainsPF137161511779547 MCF2L2
3.891e-02-3.25Sec7pfam domainsPF013691511779547 IQSEC2
3.897e-02-3.24Sec7_dom_sfinterpro domainsIPR0359991511852149 IQSEC2
3.897e-02-3.24Sec7_C_sfinterpro domainsIPR0233941511852149 IQSEC2
3.897e-02-3.24Dynamin_Ninterpro domainsIPR0450631511852149 DNM1
3.897e-02-3.24Syntaxin/epimorphin_CSinterpro domainsIPR0060121511852149 STX1A
3.898e-02-3.24Gastric acid secretionKEGG pathwayshsa04971752716130 CAMK2B,CAMK2A
3.898e-02-3.24Gastric acid secretionKEGG pathwaysko04971752716130 CAMK2A,CAMK2B
3.900e-02-3.24chloride transportbiological processGO:000682112121820447 SLC4A10,GABRB2
3.915e-02-3.24regulation of anatomical structure sizebiological processGO:009006649841820447 DNM1,SPTBN2,SPTBN4,L1CAM
3.930e-02-3.24A2ML1 (alpha-2-macroglobulin like 1)protein interactions14456812221945450 HCN1,SPTBN4
3.930e-02-3.24BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)protein interactions5584512221945450 PPFIA2,PPFIA3
3.939e-02-3.23endocytosisbiological processGO:000689749941820447 DNM1,SYT1,SNAP25,STX1A
3.943e-02-3.23human chr10q23.1chromosome locationhuman chr10q23.12112613450 NRG3
3.950e-02-3.23basal plasma membranecellular componentGO:000992528831910850 SLC4A10,LRRC7,DLG4
3.955e-02-3.23EGFsmart domainsSM001811843971740 NRXN2,NRXN3,EDIL3
3.970e-02-3.23regulation of cellular localizationbiological processGO:006034198361820447 SNAP25,VSNL1,CPLX1,IQSEC2,STX1A,GRIN1
3.988e-02-3.22transmembrane-ephrin receptor activitymolecular functionGO:00050051511809449 EPHA6
3.988e-02-3.22EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)protein interactions889112321945450 SYT1,FGF14
3.988e-02-3.22HMOX1 (heme oxygenase 1)protein interactions316212321945450 HCN1,STX1A
4.006e-02-3.22cellular response to chemical stimulusbiological processGO:00708872411111820447 CAMK2A,CACNA1A,GRIN1,HCN1,GABRB2,RYR2,CACNA2D1,SLC8A3,BRINP1,DLG4,SYT1
4.009e-02-3.22ovary-carcinoma-endometrioid_carcinomaCOSMIC cancer mutationsovary-carcinoma-endometrioid_carcinoma46441682847 EPHA6,CAMK2A,CAMKV,CAMK2B
4.014e-02-3.22Primary Focal Segmental Glomerulosclerosis FSGSWikiPathwaysWP2572742531023 CAMK2B,DNM1
4.035e-02-3.21central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_IIICOSMIC cancer mutationscentral_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III11421682847 SLC4A10,SPTBN2
4.035e-02-3.21SLC6A9 (solute carrier family 6 member 9)protein interactions65361611945450 STX1A
4.035e-02-3.21FZD4 (frizzled class receptor 4)protein interactions83221611945450 DLG4
4.035e-02-3.21Ostm1 (osteopetrosis associated transmembrane protein 1)protein interactions146281611945450 CAMK2A
4.035e-02-3.21SYT9 (synaptotagmin 9)protein interactions1434251611945450 SNAP25
4.035e-02-3.21CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1)protein interactions7821611945450 CACNA1A
4.035e-02-3.21KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)protein interactions37611611945450 DLG4
4.035e-02-3.21CNTNAP2 (contactin associated protein 2)protein interactions260471611945450 DLG4
4.035e-02-3.21GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3)protein interactions25621611945450 GABRB2
4.035e-02-3.21AKAP6 (A-kinase anchoring protein 6)protein interactions94721611945450 RYR2
4.035e-02-3.21GMPR2 (guanosine monophosphate reductase 2)protein interactions512921611945450 DNM1
4.035e-02-3.21RBM18 (RNA binding motif protein 18)protein interactions924001611945450 SYT1
4.035e-02-3.21ZFAND3 (zinc finger AN1-type containing 3)protein interactions606851611945450 DNM1
4.035e-02-3.21DUS1L (dihydrouridine synthase 1 like)protein interactions641181611945450 CAMK2B
4.037e-02-3.21protein phosphorylationbiological processGO:000646850341820447 CAMK2A,EPHA6,CAMK2B,CAMKV
4.043e-02-3.21MIRsmart domainsSM00472101971740 RYR2
4.054e-02-3.21angiotensin-activated signaling pathwaybiological processGO:00381661611820447 CAMK2A
4.054e-02-3.21mitochondrial calcium ion transmembrane transportbiological processGO:00068511611820447 SLC8A3
4.054e-02-3.21desensitization of G protein-coupled receptor signaling pathwaybiological processGO:00020291611820447 GRM5
4.054e-02-3.21cardiac left ventricle morphogenesisbiological processGO:00032141611820447 RYR2
4.054e-02-3.21regulation of postsynaptic specialization assemblybiological processGO:00991501611820447 SPTBN2
4.055e-02-3.21Cellular response to heat stressREACTOME pathwaysR-HSA-33715568921028537 CAMK2B,CAMK2A
4.077e-02-3.20regulation of protein-containing complex disassemblybiological processGO:004324412421820447 SPTBN4,SPTBN2
4.087e-02-3.20response to inorganic substancebiological processGO:001003550541820447 CACNA1G,SYT1,RYR2,DLG4
4.106e-02-3.19STXBP1 (syntaxin binding protein 1)protein interactions681212521945450 STX1A,SNAP25
4.106e-02-3.19CBLN4 (cerebellin 4 precursor)protein interactions14068912521945450 NRXN3,L1CAM
4.106e-02-3.19ZNF250 (zinc finger protein 250)protein interactions5850012521945450 CCDC136,STX1A
4.110e-02-3.19Galactose-binding domain-likegene3d domains2.60.120.2609721447048 EPHA6,EDIL3
4.127e-02-3.19chloride transmembrane transporter activitymolecular functionGO:001510811921809449 GABRB2,SLC4A10
4.127e-02-3.19human chr12q21.31chromosome locationhuman chr12q21.312212613450 PPFIA2
4.127e-02-3.19human chr5p12chromosome locationhuman chr5p122212613450 HCN1
4.145e-02-3.18EF-hand_1pfam domainsPF000361611779547 VSNL1
4.152e-02-3.18Sec7_dominterpro domainsIPR0009041611852149 IQSEC2
4.152e-02-3.18Guanylate_kinase_CSinterpro domainsIPR0205901611852149 DLG4
4.152e-02-3.18cNMP-bd_CSinterpro domainsIPR0184881611852149 HCN1
4.152e-02-3.18Syntaxininterpro domainsIPR0452421611852149 STX1A
4.170e-02-3.18EPH_LBDprosite domainsPS515501411218637 EPHA6
4.170e-02-3.18RECEPTOR_TYR_KIN_V_2prosite domainsPS007911411218637 EPHA6
4.170e-02-3.18G_DYNAMIN_2prosite domainsPS517181411218637 DNM1
4.170e-02-3.18RECEPTOR_TYR_KIN_V_1prosite domainsPS007901411218637 EPHA6
4.170e-02-3.18RASGEFprosite domainsPS007201411218637 RASGRF1
4.197e-02-3.17response to ethanolbiological processGO:004547112621820447 GRIN2B,GRIN1
4.219e-02-3.17HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)protein interactions914651241945450 EPHA6,DLG4,CCDC136,SNAP25
4.229e-02-3.16central_nervous_system-brain-glioma-oligoastrocytoma_Grade_IIICOSMIC cancer mutationscentral_nervous_system-brain-glioma-oligoastrocytoma_Grade_III11721682847 HCN1,RYR2
4.229e-02-3.16iswi atpasegene3d domains1.20.5.11901311447048 SCN8A
4.229e-02-3.16-gene3d domains1.20.58.701311447048 STX1A
4.229e-02-3.16GPCR, family 3, nine cysteines domaingene3d domains2.10.50.301311447048 GRM5
4.231e-02-3.16skin-head_neck-malignant_melanoma-superficial_spreadingCOSMIC cancer mutationsskin-head_neck-malignant_melanoma-superficial_spreading92361682847 MCF2L2,RASGRF1,NRXN3,CACNA2D1,SPTBN2,SYT1
4.235e-02-3.16Activation of Ca-permeable Kainate ReceptorREACTOME pathwaysR-HSA-4513081211028537 DLG4
4.235e-02-3.16Ionotropic activity of Kainate ReceptorsREACTOME pathwaysR-HSA-4513061211028537 DLG4
4.244e-02-3.16lung-carcinoma-adenocarcinomaCOSMIC cancer mutationslung-carcinoma-adenocarcinoma15133461682847 HCN1,SNAP25,MYT1L,DNM1,SCN8A,CAMK2A,STX1A,GABRB2,LRRC7,EPHA6,NRXN2,PPFIA2,IQSEC2,FGF14,SYT1,L1CAM,CACNA2D1,MCF2L2,DLG4,GRIN1,EDIL3,CACNA1C,SLC4A10,CAMK2B,CELF3,SPTBN2,SLC8A3,CCDC136,CAMKV,SPTBN4,PPFIA3,CELF5,DLGAP2,CACNA1G,ABLIM1,RYR2,CACNA1E,NRXN3,RASGRF1,PCLO,CACNA1A,RIMS1,NRG3,GRIN2B,GRM5,VSNL1
4.248e-02-3.16ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialmolecular functionGO:00995071611809449 GRIN2B
4.257e-02-3.16organelle fusionbiological processGO:004828412721820447 SNAP25,STX1A
4.282e-02-3.15ZNF12 (zinc finger protein 12)protein interactions75591711945450 STX1A
4.282e-02-3.15ZNF557 (zinc finger protein 557)protein interactions792301711945450 STX1A
4.282e-02-3.15BMP8A (bone morphogenetic protein 8a)protein interactions3535001711945450 BRINP1
4.282e-02-3.15PAX4 (paired box 4)protein interactions50781711945450 NRXN3
4.282e-02-3.15ZNF559-ZNF177 (ZNF559-ZNF177 readthrough)protein interactions1005292151711945450 SNAP25
4.282e-02-3.15FAM163B (family with sequence similarity 163 member B)protein interactions6429681711945450 CAMK2B
4.282e-02-3.15CLEC1A (C-type lectin domain family 1 member A)protein interactions512671711945450 STX1A
4.282e-02-3.15SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)protein interactions510911711945450 ABLIM1
4.282e-02-3.15IL13RA1 (interleukin 13 receptor subunit alpha 1)protein interactions35971711945450 DLG4
4.282e-02-3.15CNTN2 (contactin 2)protein interactions69001711945450 L1CAM
4.282e-02-3.15FAM131C (family with sequence similarity 131 member C)protein interactions3484871711945450 VSNL1
4.282e-02-3.15Aurkb (aurora kinase B)protein interactions208771711945450 SPTBN2
4.286e-02-3.15HOMER3 (homer scaffold protein 3)protein interactions945412821945450 LRRC7,GRM5
4.286e-02-3.15SYT2 (synaptotagmin 2)protein interactions12783312821945450 CAMKV,SYT1
4.286e-02-3.15EIF2B2 (eukaryotic translation initiation factor 2B subunit beta)protein interactions889212821945450 FGF14,SYT1
4.297e-02-3.15signaling receptor activitymolecular functionGO:0038023147481809449 GRM5,EPHA6,NRXN2,NRXN3,GRIN2B,GRIN1,L1CAM,GABRB2
4.297e-02-3.15molecular transducer activitymolecular functionGO:0060089147481809449 L1CAM,GABRB2,GRM5,EPHA6,NRXN3,NRXN2,GRIN2B,GRIN1
4.301e-02-3.15positive regulation of cardiac muscle cell apoptotic processbiological processGO:00106661711820447 CAMK2A
4.301e-02-3.15positive regulation of sequestering of calcium ionbiological processGO:00512841711820447 RYR2
4.301e-02-3.15adaptation of signaling pathwaybiological processGO:00230581711820447 GRM5
4.301e-02-3.15negative adaptation of signaling pathwaybiological processGO:00224011711820447 GRM5
4.301e-02-3.15positive regulation of striated muscle cell apoptotic processbiological processGO:00106631711820447 CAMK2A
4.301e-02-3.15negative regulation of receptor internalizationbiological processGO:00020911711820447 DLG4
4.301e-02-3.15nuclear body organizationbiological processGO:00305751711820447 CELF3
4.311e-02-3.14human chr3q11.2chromosome locationhuman chr3q11.22312613450 EPHA6
4.311e-02-3.14human chr2p25.3chromosome locationhuman chr2p25.32312613450 MYT1L
4.316e-02-3.14skin-malignant_melanomaCOSMIC cancer mutationsskin-malignant_melanoma15741471682847 SCN8A,DNM1,MYT1L,SNAP25,HCN1,PPFIA2,FGF14,IQSEC2,NRXN2,EPHA6,LRRC7,GABRB2,STX1A,CAMK2A,MCF2L2,DLG4,GRIN1,CACNA2D1,L1CAM,SYT1,CCDC136,SLC8A3,SPTBN2,CELF3,CAMK2B,CPLX1,EDIL3,SLC4A10,CACNA1C,PPFIA3,SPTBN4,CAMKV,ABLIM1,CACNA1G,DLGAP2,CELF5,CACNA1A,RIMS1,RASGRF1,PCLO,NRXN3,CACNA1E,RYR2,GRM5,VSNL1,GRIN2B,NRG3
4.317e-02-3.14potassium channel activitymolecular functionGO:000526712221809449 HCN1,SNAP25
4.317e-02-3.14myelinationbiological processGO:004255212821820447 SLC8A3,SCN8A
4.320e-02-3.14skin-back-malignant_melanomaCOSMIC cancer mutationsskin-back-malignant_melanoma28031682847 SLC8A3,PCLO,EPHA6
4.346e-02-3.14EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)protein interactions889012921945450 FGF14,SYT1
4.346e-02-3.14PNKP (polynucleotide kinase 3'-phosphatase)protein interactions1128412921945450 CAMK2A,CAMK2B
4.350e-02-3.14nucleoside-triphosphatase regulator activitymolecular functionGO:006058949141809449 RASGRF1,IQSEC2,RIMS1,MCF2L2
4.350e-02-3.14GTPase regulator activitymolecular functionGO:003069549141809449 MCF2L2,RIMS1,IQSEC2,RASGRF1
4.358e-02-3.13apical dendritecellular componentGO:00974401711910850 SLC4A10
4.406e-02-3.12Synaptotagmininterpro domainsIPR0015651711852149 SYT1
4.418e-02-3.12peptidyl-amino acid modificationbiological processGO:001819351841820447 CAMKV,STX1A,CAMK2A,CAMK2B
4.440e-02-3.11ensheathment of neuronsbiological processGO:000727213021820447 SCN8A,SLC8A3
4.440e-02-3.11axon ensheathmentbiological processGO:000836613021820447 SCN8A,SLC8A3
4.448e-02-3.11cytoskeletoncellular componentGO:00058562412111910850 RIMS1,CAMK2B,SPTBN4,DNM1,DLG4,PCLO,DLGAP2,SNAP25,SPTBN2,ABLIM1,GRIN2B
4.461e-02-3.11SEC7prosite domainsPS501901511218637 IQSEC2
4.461e-02-3.11SYNTAXINprosite domainsPS009141511218637 STX1A
4.468e-02-3.11KRTAP4-2 (keratin associated protein 4-2)protein interactions8529113121945450 DLGAP2,CELF5
4.476e-02-3.11Interferon gamma signalingREACTOME pathwaysR-HSA-8773009421028537 CAMK2B,CAMK2A
4.484e-02-3.10cell-cell junctioncellular componentGO:000591151341910850 SPTBN2,SPTBN4,LRRC7,DLG4
4.499e-02-3.10NRP1 (neuropilin 1)protein interactions882930931945450 CAMKV,ABLIM1,L1CAM
4.501e-02-3.10EAGCHANLFMLYprints domainsPR01463121522720 HCN1
4.501e-02-3.10response to calcium ionbiological processGO:005159213121820447 SYT1,RYR2
4.507e-02-3.10ephrin receptor activitymolecular functionGO:00050031711809449 EPHA6
4.509e-02-3.10protein tyrosine kinase bindingmolecular functionGO:199078212521809449 NRG3,GRM5
4.529e-02-3.09GRIK5 (glutamate ionotropic receptor kainate type subunit 5)protein interactions29011811945450 DLG4
4.529e-02-3.09CTSE (cathepsin E)protein interactions15101811945450 L1CAM
4.529e-02-3.09Ccdc77 (coiled-coil domain containing 77)protein interactions672001811945450 CACNA2D1
4.529e-02-3.09DAPK2 (death associated protein kinase 2)protein interactions236041811945450 CAMK2A
4.529e-02-3.09RYR3 (ryanodine receptor 3)protein interactions62631811945450 RYR2
4.529e-02-3.09KLHL1 (kelch like family member 1)protein interactions576261811945450 CACNA1A
4.530e-02-3.09INA (internexin neuronal intermediate filament protein alpha)protein interactions911813221945450 GRIN1,CAMK2A
4.535e-02-3.09response to chemicalbiological processGO:00422213743151820447 GRIN2B,SYT1,NRG3,BRINP1,DLG4,CACNA2D1,SLC8A3,CACNA1G,RYR2,L1CAM,CACNA1A,CAMK2A,HCN1,GABRB2,GRIN1
4.546e-02-3.09organelle organizationbiological processGO:00069963091131820447 SNAP25,DNM1,CELF3,DLG4,NRXN2,SPTBN4,PCLO,CCDC136,SPTBN2,STX1A,ABLIM1,CAMK2A,IQSEC2
4.547e-02-3.09ephrin a2 ectodomaingene3d domains2.60.40.17701411447048 EPHA6
4.549e-02-3.09regulation of calcium ion transport into cytosolbiological processGO:00105221811820447 GRIN1
4.549e-02-3.09regulation of skeletal muscle contractionbiological processGO:00148191811820447 SLC8A3
4.549e-02-3.09positive regulation of dendritic spine morphogenesisbiological processGO:00610031811820447 CAMK2B
4.549e-02-3.09dendritic spine morphogenesisbiological processGO:00609971811820447 DLG4
4.549e-02-3.09clathrin coat assemblybiological processGO:00482681811820447 DNM1
4.549e-02-3.09type B pancreatic cell proliferationbiological processGO:00443421811820447 RASGRF1
4.563e-02-3.09regulation of mRNA processingbiological processGO:005068413221820447 CELF5,CELF3
4.580e-02-3.08GABA A receptor activationREACTOME pathwaysR-HSA-9774411311028537 GABRB2
4.580e-02-3.08Sodium/Calcium exchangersREACTOME pathwaysR-HSA-4255611311028537 SLC8A3
4.580e-02-3.08ERBB2 Activates PTK6 SignalingREACTOME pathwaysR-HSA-88479931311028537 NRG3
4.582e-02-3.08Taste transductionKEGG pathwaysko04742822716130 CACNA1A,CACNA1C
4.582e-02-3.08Taste transductionKEGG pathwayshsa04742822716130 CACNA1A,CACNA1C
4.591e-02-3.08PTPRS (protein tyrosine phosphatase receptor type S)protein interactions580213321945450 PPFIA3,PPFIA2
4.609e-02-3.08calyx of Heldcellular componentGO:00443051811910850 CPLX1
4.625e-02-3.07regulation of sequestering of calcium ionbiological processGO:005128213321820447 RYR2,CACNA1C
4.627e-02-3.07basal part of cellcellular componentGO:004517830731910850 DLG4,LRRC7,SLC4A10
4.627e-02-3.07bone-humerus-chondrosarcomaCOSMIC cancer mutationsbone-humerus-chondrosarcoma12321682847 PCLO,RYR2
4.653e-02-3.07EPHB4 (EPH receptor B4)protein interactions205013421945450 EPHA6,GRIN1
4.659e-02-3.07SNAREinterpro domainsIPR0109891811852149 STX1A
4.661e-02-3.07Neurotrophic factor-mediated Trk receptor signalingPathway Interaction DBtrkrpathway562222614 RASGRF1,DNM1
4.667e-02-3.06Serotonin Transporter ActivityWikiPathwaysWP1455111531023 STX1A
4.672e-02-3.06actin cytoskeletoncellular componentGO:001562952041910850 ABLIM1,SPTBN2,SNAP25,SPTBN4
4.677e-02-3.06human chr5q34chromosome locationhuman chr5q342512613450 GABRB2
4.677e-02-3.06exocytic vesicle membranecellular componentGO:009950113221910850 SYT1,STX1A
4.677e-02-3.06synaptic vesicle membranecellular componentGO:003067213221910850 STX1A,SYT1
4.679e-02-3.06salivary_gland-carcinoma-adenoid_cystic_carcinomaCOSMIC cancer mutationssalivary_gland-carcinoma-adenoid_cystic_carcinoma48841682847 SLC4A10,RYR2,GRIN2B,L1CAM
4.688e-02-3.06regulation of actin filament polymerizationbiological processGO:003083313421820447 SPTBN2,SPTBN4
4.688e-02-3.06vesicle-mediated transport to the plasma membranebiological processGO:009887613421820447 SNAP25,LRRC7
4.716e-02-3.05Myo1c (myosin IC)protein interactions1791313521945450 SPTBN2,ABLIM1
4.737e-02-3.05regulation of establishment of protein localizationbiological processGO:007020153041820447 VSNL1,CPLX1,SNAP25,STX1A
4.752e-02-3.05FA58C_2prosite domainsPS012861611218637 EDIL3
4.752e-02-3.05GUANYLATE_KINASE_1prosite domainsPS008561611218637 DLG4
4.752e-02-3.05CNMP_BINDING_1prosite domainsPS008881611218637 HCN1
4.763e-02-3.04kneeCOSMIC cancer mutationsknee12521682847 EPHA6,RYR2
4.766e-02-3.04intracellularly gated calcium channel activitymolecular functionGO:00152781811809449 RYR2
4.766e-02-3.04transmembrane receptor protein tyrosine kinase activator activitymolecular functionGO:00302971811809449 NRG3
4.766e-02-3.04adrenergic receptor bindingmolecular functionGO:00316901811809449 DLG4
4.774e-02-3.04TTC7A (tetratricopeptide repeat domain 7A)protein interactions572171911945450 CAMKV
4.774e-02-3.04NANOS1 (nanos C2HC-type zinc finger 1)protein interactions3407191911945450 GRIN1
4.774e-02-3.04RAB26 (RAB26, member RAS oncogene family)protein interactions258371911945450 RIMS1
4.774e-02-3.04LRRTM3 (leucine rich repeat transmembrane neuronal 3)protein interactions3477311911945450 NRXN3
4.774e-02-3.04CCL19 (C-C motif chemokine ligand 19)protein interactions63631911945450 CACNA2D1
4.774e-02-3.04CACNA1B (calcium voltage-gated channel subunit alpha1 B)protein interactions7741911945450 RIMS1
4.774e-02-3.04ANKRD13C (ankyrin repeat domain 13C)protein interactions815731911945450 GRIN1
4.774e-02-3.04CRIM1 (cysteine rich transmembrane BMP regulator 1)protein interactions512321911945450 CACNA1A
4.774e-02-3.04FAM170A (family with sequence similarity 170 member A)protein interactions3400691911945450 CAMK2B
4.774e-02-3.04SYT7 (synaptotagmin 7)protein interactions90661911945450 STX1A
4.774e-02-3.04ETNK2 (ethanolamine kinase 2)protein interactions552241911945450 STX1A
4.774e-02-3.04ZNF197 (zinc finger protein 197)protein interactions101681911945450 CCDC136
4.774e-02-3.04TEX13B (testis expressed 13B)protein interactions561561911945450 VSNL1
4.774e-02-3.04Cep76 (centrosomal protein 76)protein interactions2256591911945450 CACNA2D1
4.795e-02-3.04positive regulation of Ras protein signal transductionbiological processGO:00465791911820447 RASGRF1
4.795e-02-3.04regulation of calcium ion transmembrane transport via high voltage-gated calcium channelbiological processGO:19025141911820447 CACNA2D1
4.795e-02-3.04presynapse assemblybiological processGO:00990541911820447 PCLO
4.795e-02-3.04response to potassium ionbiological processGO:00358641911820447 DLG4
4.795e-02-3.04excitatory synapse assemblybiological processGO:19048611911820447 NRXN2
4.795e-02-3.04cerebellar Purkinje cell layer morphogenesisbiological processGO:00216921911820447 SPTBN2
4.795e-02-3.04positive regulation of reactive oxygen species biosynthetic processbiological processGO:19034281911820447 GRIN1
4.814e-02-3.03cell-matrix adhesionbiological processGO:000716013621820447 PPFIA2,L1CAM
4.832e-02-3.03MACPFsmart domainsSM00457121971740 BRINP1
4.859e-02-3.02GABA-A receptor complexcellular componentGO:19027111911910850 GABRB2
4.859e-02-3.02astrocyte projectioncellular componentGO:00974491911910850 GRM5
4.859e-02-3.02human chr14q24.2chromosome locationhuman chr14q24.22612613450 SLC8A3
4.859e-02-3.02human chr15q24.2chromosome locationhuman chr15q24.22612613450 TMEM266
4.864e-02-3.02Arf Nucleotide-binding Site Opener,domain 2gene3d domains1.10.1000.111511447048 IQSEC2
4.910e-02-3.01Kinase-like_dom_sfinterpro domainsIPR01100952341852149 CAMK2B,EPHA6,CAMKV,CAMK2A
4.923e-02-3.01Retrograde neurotrophin signallingREACTOME pathwaysR-HSA-1775041411028537 DNM1
4.923e-02-3.01Reduction of cytosolic Ca++ levelsREACTOME pathwaysR-HSA-4183591411028537 SLC8A3
4.923e-02-3.01SHC1 events in ERBB4 signalingREACTOME pathwaysR-HSA-12503471411028537 NRG3
4.923e-02-3.01DCC mediated attractive signalingREACTOME pathwaysR-HSA-4188851411028537 ABLIM1
4.930e-02-3.01EphrinA-EPHA pathwayPathway Interaction DBephrina_ephapathway81222614 EPHA6
4.941e-02-3.01regulation of protein localization to cell peripherybiological processGO:190437513821820447 CPLX1,IQSEC2
4.947e-02-3.01positive regulation of signal transductionbiological processGO:0009967159381820447 GRIN2B,RASGRF1,RIMS1,CAMK2A,GRM5,DLG4,STX1A,GRIN1
4.968e-02-3.00ERG28 (ergosterol biosynthesis 28 homolog)protein interactions1116113921945450 CELF3,STX1A
4.968e-02-3.00EXOC3 (exocyst complex component 3)protein interactions1133613921945450 GRIN2B,CCDC136
4.971e-02-3.00protein kinase activator activitymolecular functionGO:003029513221809449 GRM5,NRG3