Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.060e-07	-16.06	regulation of cell adhesion	biological process	GO:0030155	807	13	18204	48	VAV3,PLXND1,PREX1,ACER2,SH2B3,SLC9A1,PTPRC,SYK,TMEM131L,DISC1,DOCK8,PTPN6,DAB2
2.369e-07	-15.26	LCP2 (lymphocyte cytosolic protein 2)	protein interactions	3937	54	5	19454	49	PTPRC,VAV3,SYK,HCK,PTPN6
5.092e-07	-14.49	SH2DOMAIN	prints domains	PR00401	72	5	5227	13	HCK,VAV3,SH2B3,PTPN6,SYK
7.955e-07	-14.04	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	11	19454	49	PREX1,RAPGEF6,MPP1,CADM4,SLC9A1,PPFIBP2,GRK6,RHBDF2,OSBPL8,DOCK8,GAB1
1.453e-06	-13.44	membrane	cellular component	GO:0016020	9220	40	19108	49	STAB1,TMCC3,PREX2,CADM4,VMP1,KREMEN1,TMEM131L,TFEB,GRK6,DOCK2,MPP1,ENTPD1,RAPGEF6,SYK,CEMIP,GALNT1,PREX1,SMOX,SH2B3,OSBPL8,PLXND1,SEMA4B,PTGIR,PTPN6,ATP10D,TMTC1,RHBDF2,ACACB,PTPRC,DAB2,SLC9A1,ASCC3,ACER2,HCK,SLC16A10,DOCK8,VAV3,ATG14,FCHO2,PHKB
2.183e-06	-13.03	guanyl-nucleotide exchange factor activity	molecular function	GO:0005085	228	7	18094	48	PREX1,PTGIR,DOCK2,VAV3,PREX2,DOCK8,RAPGEF6
3.370e-06	-12.60	cell migration	biological process	GO:0016477	921	12	18204	48	PTPRC,DISC1,SYK,DOCK8,SLC9A1,DOCK2,SEMA4B,HCK,GAB1,VAV3,PLXND1,PREX1
3.511e-06	-12.56	regulation of signal transduction	biological process	GO:0009966	3114	22	18204	48	CADM4,SH2B3,PTGIR,PREX1,BMP2K,VAV3,KREMEN1,DOCK2,RBM47,RHBDF2,GRK6,DAB2,SYK,DISC1,PTPRC,TMEM131L,DOCK8,OSBPL8,PTPN6,SLC9A1,NACC2,PREX2
3.552e-06	-12.55	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	7	19454	49	SYK,HCK,GAB1,SH2B3,PTPN6,DISC1,VAV3
4.077e-06	-12.41	BLNK (B cell linker)	protein interactions	29760	43	4	19454	49	PTPN6,GAB1,SYK,VAV3
4.286e-06	-12.36	intracellular signal transduction	biological process	GO:0035556	1505	15	18204	48	HCK,DOCK2,PREX2,SLC9A1,PTPN6,DOCK8,SYK,DISC1,PTPRC,ACER2,PREX1,SH2B3,VAV3,ATG14,RAPGEF6
5.345e-06	-12.14	B cell receptor signaling pathway	biological process	GO:0050853	44	4	18204	48	VAV3,PTPN6,PTPRC,SYK
7.163e-06	-11.85	SH2	pfam domains	PF00017	100	5	17795	48	SH2B3,HCK,PTPN6,SYK,VAV3
7.537e-06	-11.80	regulation of response to stimulus	biological process	GO:0048583	4104	25	18204	48	OSBPL8,TMEM131L,RHBDF2,HCK,DAB2,GRK6,BMP2K,SH2B3,MPP1,PREX1,PTPN6,DOCK8,DISC1,PTPRC,SYK,PREX2,NACC2,SLC9A1,RBM47,DOCK2,KREMEN1,VAV3,CADM4,ACACB,PTGIR
8.135e-06	-11.72	CD247 (CD247 molecule)	protein interactions	919	51	4	19454	49	DOCK2,PTPN6,SH2B3,PTPRC
8.250e-06	-11.71	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	5	19454	49	VAV3,HCK,SH2B3,PTPN6,SYK
9.988e-06	-11.51	SH2	interpro domains	IPR000980	109	5	18521	49	VAV3,PTPN6,SH2B3,HCK,SYK
1.006e-05	-11.51	plasma membrane	cellular component	GO:0005886	5538	29	19108	49	ATP10D,PTGIR,SEMA4B,PTPN6,DAB2,PTPRC,RHBDF2,HCK,SLC9A1,PHKB,FCHO2,VAV3,DOCK8,SLC16A10,PREX2,STAB1,DOCK2,GRK6,TMEM131L,KREMEN1,VMP1,CEMIP,RAPGEF6,SYK,MPP1,ENTPD1,PLXND1,SH2B3,PREX1
1.191e-05	-11.34	SH2_dom_sf	interpro domains	IPR036860	113	5	18521	49	SH2B3,SYK,HCK,PTPN6,VAV3
1.646e-05	-11.01	SH2 domain	gene3d domains	3.30.505.10	111	5	14470	42	SYK,HCK,VAV3,SH2B3,PTPN6
1.707e-05	-10.98	cell periphery	cellular component	GO:0071944	6020	30	19108	49	DAB2,RHBDF2,PTPRC,ATP10D,SEMA4B,PTPN6,PTGIR,FCHO2,PHKB,VAV3,SLC16A10,DOCK8,HCK,SLC9A1,DOCK2,TMEM131L,GRK6,KREMEN1,VMP1,PREX2,STAB1,PLXND1,OSBPL8,PREX1,SH2B3,CEMIP,ENTPD1,MPP1,RAPGEF6,SYK
1.894e-05	-10.87	SH2	prosite domains	PS50001	107	5	12186	38	VAV3,SYK,HCK,SH2B3,PTPN6
1.901e-05	-10.87	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological process	GO:0002433	20	3	18204	48	SYK,VAV3,HCK
1.901e-05	-10.87	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	GO:0038096	20	3	18204	48	VAV3,HCK,SYK
2.063e-05	-10.79	cell motility	biological process	GO:0048870	1101	12	18204	48	SEMA4B,DOCK2,PREX1,PLXND1,HCK,GAB1,SYK,DISC1,PTPRC,DOCK8,VAV3,SLC9A1
2.194e-05	-10.73	Fc gamma R-mediated phagocytosis	KEGG pathways	hsa04666	90	5	7161	28	SYK,PTPRC,VAV3,HCK,DOCK2
2.194e-05	-10.73	Fc gamma R-mediated phagocytosis	KEGG pathways	ko04666	90	5	7161	28	HCK,VAV3,DOCK2,PTPRC,SYK
2.238e-05	-10.71	GDS_CDC24_CS	interpro domains	IPR001331	21	3	18521	49	PREX2,VAV3,PREX1
2.276e-05	-10.69	SH2	smart domains	SM00252	103	5	9717	33	PTPN6,VAV3,HCK,SH2B3,SYK
2.282e-05	-10.69	CCDC107 (coiled-coil domain containing 107)	protein interactions	203260	66	4	19454	49	ACACB,SLC9A1,RHBDF2,TMEM131L
2.558e-05	-10.57	Fc receptor mediated stimulatory signaling pathway	biological process	GO:0002431	22	3	18204	48	SYK,HCK,VAV3
2.882e-05	-10.45	INPP5D (inositol polyphosphate-5-phosphatase D)	protein interactions	3635	70	4	19454	49	GAB1,HCK,SYK,DAB2
2.887e-05	-10.45	regulation of signaling	biological process	GO:0023051	3534	22	18204	48	BMP2K,KREMEN1,VAV3,CADM4,SH2B3,PTGIR,PREX1,DOCK8,DISC1,PTPRC,TMEM131L,SYK,PTPN6,OSBPL8,NACC2,SLC9A1,PREX2,RBM47,DOCK2,RHBDF2,GRK6,DAB2
2.981e-05	-10.42	regulation of cell communication	biological process	GO:0010646	3541	22	18204	48	PREX2,SLC9A1,NACC2,OSBPL8,PTPN6,TMEM131L,SYK,DISC1,PTPRC,DOCK8,DAB2,GRK6,RHBDF2,DOCK2,RBM47,VAV3,KREMEN1,BMP2K,PREX1,PTGIR,SH2B3,CADM4
3.157e-05	-10.36	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	11	19454	49	OSBPL8,GAB1,DOCK8,DAB2,DIAPH2,DOCK2,SLC9A1,PREX2,PREX1,FCHO2,VAV3
3.579e-05	-10.24	DH_1	prosite domains	PS00741	21	3	12186	38	PREX1,VAV3,PREX2
3.595e-05	-10.23	positive regulation of cell adhesion	biological process	GO:0045785	486	8	18204	48	DAB2,PREX1,PTPN6,DOCK8,PTPRC,SYK,DISC1,VAV3
4.199e-05	-10.08	PTGIR (prostaglandin I2 receptor)	protein interactions	5739	77	4	19454	49	VMP1,SLC9A1,OSBPL8,PTGIR
4.748e-05	-9.96	T cell proliferation	biological process	GO:0042098	76	4	18204	48	PTPRC,DOCK2,DOCK8,PTPN6
5.331e-05	-9.84	intracellular signaling cassette	biological process	GO:0141124	837	10	18204	48	DOCK2,SLC9A1,VAV3,PREX2,PTPRC,SYK,DOCK8,ATG14,PTPN6,RAPGEF6
6.423e-05	-9.65	CSF2RB (colony stimulating factor 2 receptor subunit beta)	protein interactions	1439	31	3	19454	49	PTPN6,HCK,SYK
6.780e-05	-9.60	PLCG2 (phospholipase C gamma 2)	protein interactions	5336	87	4	19454	49	SYK,PTPN6,GAB1,HCK
6.910e-05	-9.58	PH_domain	interpro domains	IPR001849	266	6	18521	49	GAB1,SH2B3,OSBPL8,PREX2,VAV3,PREX1
7.442e-05	-9.51	signaling	biological process	GO:0023052	4968	26	18204	48	TMEM131L,GRK6,DAB2,HCK,GAB1,STAB1,ATG14,PREX1,ACER2,MPP1,SH2B3,SLC9A1,PREX2,SYK,DISC1,PTPRC,DOCK8,PTPN6,DOCK2,SLC16A10,SEMA4B,VAV3,KREMEN1,RAPGEF6,PTGIR,PLXND1
8.087e-05	-9.42	Fc-gamma receptor signaling pathway	biological process	GO:0038094	32	3	18204	48	HCK,VAV3,SYK
8.344e-05	-9.39	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	5	19454	49	VAV3,SYK,HCK,PTPN6,SH2B3
8.607e-05	-9.36	regulation of GTPase activity	biological process	GO:0043087	278	6	18204	48	DOCK8,RAPGEF6,PREX2,VAV3,PREX1,PLXND1
8.683e-05	-9.35	cell communication	biological process	GO:0007154	5010	26	18204	48	TMEM131L,DAB2,HCK,GRK6,STAB1,ATG14,GAB1,ACER2,PREX1,SH2B3,MPP1,PREX2,SLC9A1,PTPN6,DOCK8,DISC1,PTPRC,SYK,SEMA4B,SLC16A10,DOCK2,KREMEN1,VAV3,RAPGEF6,PLXND1,PTGIR
8.880e-05	-9.33	negative regulation of inflammatory response to antigenic stimulus	biological process	GO:0002862	33	3	18204	48	HCK,RHBDF2,SYK
9.572e-05	-9.25	Regulation of RAC1 activity	Pathway Interaction DB	rac1_reg_pathway	39	4	2226	15	DOCK2,VAV3,PREX2,PREX1
1.008e-04	-9.20	regulation of hydrolase activity	biological process	GO:0051336	726	9	18204	48	ACER2,PREX1,PLXND1,PREX2,VAV3,DOCK8,PTPRC,SYK,RAPGEF6
1.014e-04	-9.20	membrane raft distribution	biological process	GO:0031580	6	2	18204	48	PTPRC,DOCK2
1.094e-04	-9.12	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	44	16828	46	PREX2,DAB2,TFEB,KREMEN1,CADM4,ACER2,MPP1,SLC16A10,VAV3,VMP1,DOCK2,RHBDF2,BMP2K,PTGIR,PREX1,SH2B3,SEMA4B,GALNT1,ATG14,GRK6,SLC9A1,TMCC3,ACACB,BLVRA,DIAPH2,DISC1,PTPN6,GAB1,NACC2,ATP10D,TMTC1,SMOX,PPFIBP2,FCHO2,DOCK8,PTPRC,ASCC3,STAB1,SYK,RAPGEF6,OSBPL8,PPP1R7,RBM47,PLXND1
1.099e-04	-9.12	CD22 (CD22 molecule)	protein interactions	933	37	3	19454	49	PTPRC,SYK,PTPN6
1.143e-04	-9.08	regulation of cytokine-mediated signaling pathway	biological process	GO:0001959	182	5	18204	48	PTPRC,SYK,RBM47,SH2B3,PTPN6
1.183e-04	-9.04	integrin-mediated signaling pathway	biological process	GO:0007229	96	4	18204	48	SYK,VAV3,DAB2,HCK
1.192e-04	-9.03	regulation of endocytosis	biological process	GO:0030100	295	6	18204	48	PTPRC,SYK,BMP2K,DOCK2,DAB2,HCK
1.201e-04	-9.03	cytoplasm	cellular component	GO:0005737	12081	43	19108	49	RBM47,TMCC3,GRK6,TFEB,DIAPH2,BMP2K,CEMIP,GALNT1,DISC1,OSBPL8,PREX1,SMOX,SH2B3,GAB1,PTGIR,ATP10D,TMTC1,PTPRC,BLVRA,HCK,SLC9A1,ASCC3,VAV3,NACC2,FCHO2,PHKB,DOCK8,PREX2,STAB1,TMEM131L,DOCK2,VMP1,MPP1,RAPGEF6,SYK,PPFIBP2,PPP1R7,PTPN6,RHBDF2,ACACB,DAB2,ACER2,ATG14
1.211e-04	-9.02	negative regulation of response to external stimulus	biological process	GO:0032102	428	7	18204	48	KREMEN1,SYK,PTPRC,PTPN6,HCK,RHBDF2,SH2B3
1.269e-04	-8.97	regulation of cell motility	biological process	GO:2000145	1122	11	18204	48	DAB2,SEMA4B,DOCK8,PTPRC,OSBPL8,PLXND1,PREX1,CADM4,MPP1,GAB1,CEMIP
1.284e-04	-8.96	regulation of molecular function	biological process	GO:0065009	2005	15	18204	48	HCK,DAB2,SLC9A1,PREX2,VMP1,DOCK8,PTPRC,SYK,DISC1,ACER2,PREX1,PLXND1,VAV3,RAPGEF6,CEMIP
1.300e-04	-8.95	PH-like_dom_sf	interpro domains	IPR011993	431	7	18521	49	DAB2,OSBPL8,PREX2,PREX1,GAB1,VAV3,SH2B3
1.386e-04	-8.88	hematopoietic progenitor cell differentiation	biological process	GO:0002244	100	4	18204	48	PTPRC,RBM47,SH2B3,PTPN6
1.416e-04	-8.86	prostate	COSMIC cancer mutations	prostate	13883	46	16828	46	RAPGEF6,PLXND1,RBM47,PPP1R7,OSBPL8,STAB1,SYK,ENTPD1,ATP10D,NACC2,GAB1,PTPN6,TMTC1,DIAPH2,BLVRA,DISC1,HCK,ASCC3,PTPRC,SMOX,DOCK8,FCHO2,PPFIBP2,SLC9A1,GRK6,ATG14,SEMA4B,SH2B3,GALNT1,ACACB,TMCC3,ACER2,MPP1,CADM4,SLC16A10,PREX2,KREMEN1,TFEB,DAB2,BMP2K,PTGIR,RHBDF2,PREX1,DOCK2,VMP1,VAV3
1.418e-04	-8.86	positive regulation of gamma-delta T cell differentiation	biological process	GO:0045588	7	2	18204	48	SYK,PTPRC
1.418e-04	-8.86	autophagosome membrane docking	biological process	GO:0016240	7	2	18204	48	VMP1,ATG14
1.418e-04	-8.86	membrane raft localization	biological process	GO:0051665	7	2	18204	48	DOCK2,PTPRC
1.440e-04	-8.85	platelet activation	biological process	GO:0030168	101	4	18204	48	ENTPD1,PTPN6,SYK,VAV3
1.442e-04	-8.84	PH	pfam domains	PF00169	187	5	17795	48	VAV3,GAB1,OSBPL8,PREX2,SH2B3
1.455e-04	-8.84	regulation of small GTPase mediated signal transduction	biological process	GO:0051056	306	6	18204	48	DOCK8,VAV3,PREX2,DOCK2,CADM4,PREX1
1.466e-04	-8.83	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	39	16828	46	PREX2,DIAPH2,TFEB,KREMEN1,DISC1,DAB2,MPP1,ACER2,ATP10D,GAB1,PTPN6,NACC2,SLC16A10,TMTC1,VMP1,DOCK8,DOCK2,PPFIBP2,VAV3,PTGIR,BMP2K,HCK,RHBDF2,PTPRC,PREX1,ASCC3,SEMA4B,STAB1,SH2B3,GALNT1,SYK,RAPGEF6,RBM47,PLXND1,GRK6,PPP1R7,SLC9A1,TMCC3,ACACB
1.488e-04	-8.81	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	39	16828	46	ACACB,TMCC3,RAPGEF6,PPP1R7,SLC9A1,PLXND1,RBM47,GRK6,STAB1,SH2B3,SEMA4B,GALNT1,SYK,HCK,RHBDF2,PTGIR,BMP2K,PTPRC,ASCC3,PREX1,PPFIBP2,VAV3,VMP1,DOCK8,DOCK2,GAB1,PTPN6,NACC2,ACER2,MPP1,ATP10D,TMTC1,SLC16A10,PREX2,DIAPH2,DISC1,DAB2,TFEB,KREMEN1
1.496e-04	-8.81	regulation of phagocytosis	biological process	GO:0050764	102	4	18204	48	HCK,DOCK2,PTPRC,SYK
1.541e-04	-8.78	regulation of response to cytokine stimulus	biological process	GO:0060759	194	5	18204	48	SH2B3,PTPN6,RBM47,PTPRC,SYK
1.562e-04	-8.76	negative regulation of cell adhesion	biological process	GO:0007162	310	6	18204	48	PLXND1,ACER2,PTPN6,SH2B3,TMEM131L,PTPRC
1.582e-04	-8.75	VAV1 (vav guanine nucleotide exchange factor 1)	protein interactions	7409	204	5	19454	49	HCK,GAB1,DOCK2,PTPN6,SYK
1.656e-04	-8.71	negative regulation of immune response	biological process	GO:0050777	197	5	18204	48	PTPRC,SYK,RHBDF2,PTPN6,HCK
1.704e-04	-8.68	T cell activation	biological process	GO:0042110	315	6	18204	48	PTPN6,DOCK8,PTPRC,SYK,DOCK2,PREX1
1.755e-04	-8.65	regulation of locomotion	biological process	GO:0040012	1164	11	18204	48	CEMIP,GAB1,PLXND1,PREX1,MPP1,CADM4,OSBPL8,PTPRC,DOCK8,DAB2,SEMA4B
1.818e-04	-8.61	negative regulation of inflammatory response	biological process	GO:0050728	201	5	18204	48	PTPN6,RHBDF2,PTPRC,SYK,HCK
1.852e-04	-8.59	CRKL (CRK like proto-oncogene, adaptor protein)	protein interactions	1399	211	5	19454	49	SYK,HCK,GAB1,DOCK2,PPFIBP2
1.855e-04	-8.59	regulation of intracellular signal transduction	biological process	GO:1902531	1832	14	18204	48	VAV3,PREX1,CADM4,SH2B3,NACC2,SLC9A1,PREX2,DOCK8,PTPRC,SYK,PTPN6,OSBPL8,DAB2,DOCK2
1.978e-04	-8.53	EPOR (erythropoietin receptor)	protein interactions	2057	45	3	19454	49	GAB1,PTPN6,SYK
2.045e-04	-8.49	positive regulation of hydrolase activity	biological process	GO:0051345	466	7	18204	48	PREX2,DOCK8,SYK,PTPRC,RAPGEF6,ACER2,PREX1
2.046e-04	-8.49	PH	smart domains	SM00233	259	6	9717	33	VAV3,PREX2,PREX1,OSBPL8,SH2B3,GAB1
2.168e-04	-8.44	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	gene3d domains	2.30.29.30	431	7	14470	42	OSBPL8,SH2B3,VAV3,DAB2,PREX1,GAB1,PREX2
2.212e-04	-8.42	KLRA1P (killer cell lectin like receptor A1, pseudogene)	protein interactions	10748	9	2	19454	49	SYK,PTPN6
2.223e-04	-8.41	signal transduction	biological process	GO:0007165	4637	24	18204	48	VAV3,KREMEN1,RAPGEF6,PTGIR,PLXND1,SLC9A1,PREX2,SYK,DISC1,PTPRC,DOCK8,PTPN6,DOCK2,SEMA4B,GAB1,ATG14,PREX1,ACER2,MPP1,SH2B3,TMEM131L,GRK6,HCK,DAB2
2.259e-04	-8.40	negative regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050732	45	3	18204	48	PTPN6,CADM4,PTPRC
2.422e-04	-8.33	gamma-delta T cell differentiation	biological process	GO:0042492	9	2	18204	48	SYK,PTPRC
2.422e-04	-8.33	positive regulation of gamma-delta T cell activation	biological process	GO:0046645	9	2	18204	48	SYK,PTPRC
2.422e-04	-8.33	regulation of gamma-delta T cell differentiation	biological process	GO:0045586	9	2	18204	48	SYK,PTPRC
2.464e-04	-8.31	response to external stimulus	biological process	GO:0009605	1882	14	18204	48	SEMA4B,DOCK2,HCK,PTPN6,SYK,DISC1,PTPRC,SLC9A1,PREX1,PTGIR,STAB1,GAB1,TFEB,VAV3
2.480e-04	-8.30	RHOF (ras homolog family member F, filopodia associated)	protein interactions	54509	671	8	19454	49	FCHO2,SLC9A1,BLVRA,OSBPL8,DOCK8,GAB1,DAB2,DIAPH2
2.571e-04	-8.27	T cell selection	biological process	GO:0045058	47	3	18204	48	PTPRC,SYK,DOCK2
2.596e-04	-8.26	Nef and signal transduction	REACTOME pathways	R-HSA-164944	8	2	10285	32	DOCK2,HCK
2.608e-04	-8.25	RHOU (ras homolog family member U)	protein interactions	58480	507	7	19454	49	DAB2,SYK,OSBPL8,GAB1,FCHO2,BLVRA,GRK6
2.617e-04	-8.25	phosphotyrosine residue binding	molecular function	GO:0001784	47	3	18094	48	SYK,HCK,PTPN6
2.738e-04	-8.20	regulation of inflammatory response to antigenic stimulus	biological process	GO:0002861	48	3	18204	48	HCK,SYK,RHBDF2
2.783e-04	-8.19	chemotaxis	biological process	GO:0006935	345	6	18204	48	DOCK2,SEMA4B,PREX1,GAB1,SYK,VAV3
2.822e-04	-8.17	regulation of cell-substrate adhesion	biological process	GO:0010810	221	5	18204	48	SLC9A1,PREX1,ACER2,DAB2,DISC1
2.870e-04	-8.16	taxis	biological process	GO:0042330	347	6	18204	48	GAB1,SYK,VAV3,SEMA4B,DOCK2,PREX1
2.911e-04	-8.14	regulation of cell adhesion mediated by integrin	biological process	GO:0033628	49	3	18204	48	SYK,PTPN6,ACER2
2.917e-04	-8.14	GTPase regulator activity	molecular function	GO:0030695	491	7	18094	48	PREX2,VAV3,DOCK2,PTGIR,PREX1,RAPGEF6,DOCK8
2.917e-04	-8.14	nucleoside-triphosphatase regulator activity	molecular function	GO:0060589	491	7	18094	48	DOCK2,VAV3,PREX1,PTGIR,PREX2,RAPGEF6,DOCK8
2.989e-04	-8.12	JAK1 (Janus kinase 1)	protein interactions	3716	234	5	19454	49	DISC1,PTPRC,SYK,PTPN6,GAB1
3.101e-04	-8.08	endocytosis	biological process	GO:0006897	499	7	18204	48	VAV3,SYK,FCHO2,STAB1,DAB2,HCK,DOCK2
3.257e-04	-8.03	immune response-activating cell surface receptor signaling pathway	biological process	GO:0002429	228	5	18204	48	PTPN6,PTPRC,SYK,HCK,VAV3
3.423e-04	-7.98	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	17	16828	46	ASCC3,PTGIR,VMP1,DOCK2,DOCK8,ENTPD1,TMCC3,PLXND1,SLC9A1,ATG14,OSBPL8,TMTC1,ATP10D,RAPGEF6,PTPN6,GALNT1,STAB1
3.571e-04	-7.94	regulation of B cell activation	biological process	GO:0050864	128	4	18204	48	VAV3,PTPN6,PTPRC,SYK
3.688e-04	-7.91	regulation of gamma-delta T cell activation	biological process	GO:0046643	11	2	18204	48	PTPRC,SYK
3.706e-04	-7.90	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	33	16828	46	SEMA4B,SH2B3,STAB1,SYK,GRK6,PPP1R7,PLXND1,OSBPL8,ATG14,TMCC3,ACACB,DIAPH2,BLVRA,PREX2,ATP10D,MPP1,NACC2,GAB1,CADM4,SLC16A10,TMTC1,DOCK2,DOCK8,VMP1,FCHO2,VAV3,PPFIBP2,PTGIR,BMP2K,HCK,PREX1,ASCC3,PTPRC
3.714e-04	-7.90	DOCKER_Lobe_C	interpro domains	IPR046773	11	2	18521	49	DOCK8,DOCK2
3.714e-04	-7.90	DOCKER_Lobe_B	interpro domains	IPR046770	11	2	18521	49	DOCK8,DOCK2
3.714e-04	-7.90	DOCKER_Lobe_A	interpro domains	IPR046769	11	2	18521	49	DOCK2,DOCK8
3.714e-04	-7.90	C2_DOCK-type_domain	interpro domains	IPR027007	11	2	18521	49	DOCK2,DOCK8
3.714e-04	-7.90	DOCKER_dom	interpro domains	IPR027357	11	2	18521	49	DOCK8,DOCK2
3.714e-04	-7.90	DOCK_C_lobe_A	interpro domains	IPR043161	11	2	18521	49	DOCK2,DOCK8
3.714e-04	-7.90	DOCK_C_lobe_C	interpro domains	IPR043162	11	2	18521	49	DOCK8,DOCK2
3.714e-04	-7.90	DOCK	interpro domains	IPR026791	11	2	18521	49	DOCK8,DOCK2
3.726e-04	-7.90	regulation of cell migration	biological process	GO:0030334	1061	10	18204	48	PTPRC,GAB1,DOCK8,CEMIP,OSBPL8,PREX1,PLXND1,DAB2,MPP1,SEMA4B
3.788e-04	-7.88	lymphocyte proliferation	biological process	GO:0046651	130	4	18204	48	DOCK8,PTPRC,DOCK2,PTPN6
3.790e-04	-7.88	PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)	protein interactions	5294	56	3	19454	49	GAB1,SYK,CEMIP
3.831e-04	-7.87	PICALM (phosphatidylinositol binding clathrin assembly protein)	protein interactions	8301	247	5	19454	49	DAB2,RBM47,FCHO2,BMP2K,VMP1
3.858e-04	-7.86	DOCK-C2	pfam domains	PF14429	11	2	17795	48	DOCK2,DOCK8
3.858e-04	-7.86	DHR-2_Lobe_A	pfam domains	PF06920	11	2	17795	48	DOCK2,DOCK8
3.858e-04	-7.86	DHR-2_Lobe_C	pfam domains	PF20421	11	2	17795	48	DOCK8,DOCK2
3.858e-04	-7.86	DHR-2_Lobe_B	pfam domains	PF20422	11	2	17795	48	DOCK8,DOCK2
3.870e-04	-7.86	locomotion	biological process	GO:0040011	367	6	18204	48	PREX1,SEMA4B,DOCK2,VAV3,GAB1,SYK
3.902e-04	-7.85	MET (MET proto-oncogene, receptor tyrosine kinase)	protein interactions	4233	248	5	19454	49	SYK,SH2B3,GAB1,HCK,VAV3
3.915e-04	-7.85	import into cell	biological process	GO:0098657	687	8	18204	48	STAB1,FCHO2,SYK,VAV3,SLC9A1,DOCK2,HCK,DAB2
3.993e-04	-7.83	PTPRC (protein tyrosine phosphatase receptor type C)	protein interactions	5788	57	3	19454	49	PPFIBP2,PTPRC,PTPN6
4.036e-04	-7.81	SOWAHB (sosondowah ankyrin repeat domain family member B)	protein interactions	345079	12	2	19454	49	DIAPH2,RAPGEF6
4.068e-04	-7.81	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	43	16828	46	SMOX,PPFIBP2,DOCK8,HCK,ASCC3,PTPRC,DIAPH2,BLVRA,GAB1,NACC2,PTPN6,ATP10D,TMTC1,ENTPD1,STAB1,SYK,RAPGEF6,OSBPL8,RBM47,PLXND1,PPP1R7,VAV3,DOCK2,VMP1,RHBDF2,PTGIR,BMP2K,PREX1,PREX2,DAB2,KREMEN1,TFEB,ACER2,MPP1,SLC16A10,TMCC3,ACACB,SH2B3,SEMA4B,GALNT1,ATG14,GRK6,SLC9A1
4.099e-04	-7.80	Fc receptor signaling pathway	biological process	GO:0038093	55	3	18204	48	SYK,HCK,VAV3
4.099e-04	-7.80	neutrophil chemotaxis	biological process	GO:0030593	55	3	18204	48	SYK,PREX1,VAV3
4.213e-04	-7.77	B Cell Receptor Signaling Pathway	WikiPathways	WP23	98	4	5310	20	PTPRC,GAB1,PTPN6,SYK
4.249e-04	-7.76	mononuclear cell proliferation	biological process	GO:0032943	134	4	18204	48	DOCK8,DOCK2,PTPRC,PTPN6
4.418e-04	-7.72	positive thymic T cell selection	biological process	GO:0045059	12	2	18204	48	DOCK2,PTPRC
4.418e-04	-7.72	negative thymic T cell selection	biological process	GO:0045060	12	2	18204	48	DOCK2,PTPRC
4.443e-04	-7.72	cell surface receptor signaling pathway	biological process	GO:0007166	1992	14	18204	48	GAB1,VAV3,KREMEN1,SH2B3,PLXND1,SYK,DISC1,TMEM131L,PTPRC,PTPN6,SEMA4B,GRK6,HCK,DAB2
4.449e-04	-7.72	-	gene3d domains	1.20.58.740	11	2	14470	42	DOCK2,DOCK8
4.449e-04	-7.72	-	gene3d domains	1.25.40.410	11	2	14470	42	DOCK2,DOCK8
4.527e-04	-7.70	leukocyte migration	biological process	GO:0050900	245	5	18204	48	PREX1,VAV3,HCK,SYK,DOCK8
4.763e-04	-7.65	SEMA4A (semaphorin 4A)	protein interactions	64218	13	2	19454	49	SEMA4B,PLXND1
4.763e-04	-7.65	FCRL3 (Fc receptor like 3)	protein interactions	115352	13	2	19454	49	SYK,PTPN6
4.881e-04	-7.62	antigen receptor-mediated signaling pathway	biological process	GO:0050851	139	4	18204	48	VAV3,PTPN6,SYK,PTPRC
4.895e-04	-7.62	VIRMA (vir like m6A methyltransferase associated)	protein interactions	25962	2914	17	19454	49	PHKB,PLXND1,TMCC3,ACACB,DISC1,RBM47,TMTC1,BMP2K,OSBPL8,GAB1,DIAPH2,VMP1,ASCC3,ATP10D,PREX1,RAPGEF6,TMEM131L
4.926e-04	-7.62	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	5	19454	49	GAB1,ATG14,MPP1,FCHO2,SLC9A1
5.015e-04	-7.60	FBXO2 (F-box protein 2)	protein interactions	26232	403	6	19454	49	TMEM131L,CADM4,OSBPL8,PLXND1,CEMIP,SEMA4B
5.116e-04	-7.58	DOCKER	prosite domains	PS51651	11	2	12186	38	DOCK8,DOCK2
5.116e-04	-7.58	C2_DOCK	prosite domains	PS51650	11	2	12186	38	DOCK2,DOCK8
5.213e-04	-7.56	negative T cell selection	biological process	GO:0043383	13	2	18204	48	PTPRC,DOCK2
5.392e-04	-7.53	protein phosphorylated amino acid binding	molecular function	GO:0045309	60	3	18094	48	SYK,HCK,PTPN6
5.547e-04	-7.50	MS4A2 (membrane spanning 4-domains A2)	protein interactions	2206	14	2	19454	49	SYK,PTPN6
5.598e-04	-7.49	cell activation	biological process	GO:0001775	725	8	18204	48	PREX1,DOCK2,ENTPD1,VAV3,PTPRC,SYK,DOCK8,PTPN6
5.696e-04	-7.47	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	7	16828	46	VMP1,DOCK2,OSBPL8,VAV3,PREX1,DIAPH2,TMCC3
5.961e-04	-7.43	PDZ	interpro domains	IPR001478	146	4	18521	49	RAPGEF6,MPP1,PREX1,PREX2
6.071e-04	-7.41	immunological synapse formation	biological process	GO:0001771	14	2	18204	48	DOCK2,DOCK8
6.071e-04	-7.41	alpha-beta T cell proliferation	biological process	GO:0046633	14	2	18204	48	PTPRC,DOCK2
6.093e-04	-7.40	GPVI-mediated activation cascade	REACTOME pathways	R-HSA-114604	54	3	10285	32	VAV3,SYK,PTPN6
6.132e-04	-7.40	Chemokine signaling pathway	KEGG pathways	ko04062	182	5	7161	28	DOCK2,VAV3,HCK,PREX1,GRK6
6.132e-04	-7.40	Chemokine signaling pathway	KEGG pathways	hsa04062	182	5	7161	28	HCK,VAV3,DOCK2,PREX1,GRK6
6.140e-04	-7.40	immune response-regulating cell surface receptor signaling pathway	biological process	GO:0002768	262	5	18204	48	HCK,VAV3,PTPN6,SYK,PTPRC
6.329e-04	-7.37	RHOA (ras homolog family member A)	protein interactions	387	1186	10	19454	49	OSBPL8,GAB1,PREX2,VMP1,DIAPH2,DAB2,PREX1,VAV3,SLC9A1,BLVRA
6.391e-04	-7.36	PTPRCAP (protein tyrosine phosphatase receptor type C associated protein)	protein interactions	5790	15	2	19454	49	OSBPL8,PTPRC
6.434e-04	-7.35	PDZ_sf	interpro domains	IPR036034	149	4	18521	49	RAPGEF6,MPP1,PREX1,PREX2
7.002e-04	-7.26	leukocyte proliferation	biological process	GO:0070661	153	4	18204	48	PTPN6,DOCK2,PTPRC,DOCK8
7.006e-04	-7.26	peptidyl-tyrosine phosphorylation	biological process	GO:0018108	66	3	18204	48	HCK,PTPN6,SYK
7.006e-04	-7.26	neutrophil migration	biological process	GO:1990266	66	3	18204	48	VAV3,PREX1,SYK
7.161e-04	-7.24	FCGR activation	REACTOME pathways	R-HSA-2029481	13	2	10285	32	SYK,HCK
7.540e-04	-7.19	IL-3 Signaling Pathway	WikiPathways	WP286	49	3	5310	20	PTPN6,HCK,SYK
7.545e-04	-7.19	enzyme binding	molecular function	GO:0019899	2086	14	18094	48	PTPRC,PREX1,ATG14,CADM4,NACC2,SLC9A1,SYK,RBM47,TFEB,DOCK2,PTPN6,DIAPH2,RAPGEF6,SH2B3
7.555e-04	-7.19	T cell receptor complex	cellular component	GO:0042101	16	2	19108	49	SYK,PTPN6
7.645e-04	-7.18	peptidyl-tyrosine modification	biological process	GO:0018212	68	3	18204	48	SYK,PTPN6,HCK
7.693e-04	-7.17	membrane organization	biological process	GO:0061024	761	8	18204	48	DOCK2,SLC9A1,VAV3,VMP1,ATP10D,PTPRC,OSBPL8,FCHO2
7.712e-04	-7.17	positive regulation of endocytosis	biological process	GO:0045807	157	4	18204	48	DAB2,PTPRC,SYK,DOCK2
7.853e-04	-7.15	RASA1 (RAS p21 protein activator 1)	protein interactions	5921	165	4	19454	49	SYK,HCK,GAB1,PTPRC
7.865e-04	-7.15	cytosol	cellular component	GO:0005829	5475	25	19108	49	OSBPL8,PPFIBP2,DISC1,SH2B3,SMOX,PREX1,RAPGEF6,SYK,DOCK2,TFEB,DIAPH2,PREX2,PHKB,ATG14,FCHO2,VAV3,DOCK8,HCK,ASCC3,DAB2,ACACB,BLVRA,GAB1,PTPN6,PTGIR
8.020e-04	-7.13	regulation of transport	biological process	GO:0051049	1621	12	18204	48	CEMIP,BMP2K,PTPRC,SYK,OSBPL8,PTPN6,SLC9A1,VMP1,DOCK2,RHBDF2,DAB2,HCK
8.038e-04	-7.13	RHOQ (ras homolog family member Q)	protein interactions	23433	441	6	19454	49	DOCK8,GAB1,OSBPL8,SLC9A1,DIAPH2,FCHO2
8.054e-04	-7.12	MIB1 (MIB E3 ubiquitin protein ligase 1)	protein interactions	57534	291	5	19454	49	ASCC3,DAB2,TMCC3,FCHO2,CEMIP
8.399e-04	-7.08	GAB1 (GRB2 associated binding protein 1)	protein interactions	2549	168	4	19454	49	VAV3,HCK,GAB1,SYK
8.410e-04	-7.08	DH-domain	interpro domains	IPR000219	70	3	18521	49	VAV3,PREX1,PREX2
8.584e-04	-7.06	positive regulation of cell migration	biological process	GO:0030335	592	7	18204	48	GAB1,PTPRC,DOCK8,CEMIP,SEMA4B,PREX1,DAB2
8.688e-04	-7.05	Wnt signaling pathway	biological process	GO:0016055	283	5	18204	48	TMEM131L,DISC1,DAB2,KREMEN1,GRK6
8.765e-04	-7.04	DBL_dom_sf	interpro domains	IPR035899	71	3	18521	49	PREX2,PREX1,VAV3
8.791e-04	-7.04	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	31	16828	46	ACACB,TMCC3,PPP1R7,SLC9A1,PLXND1,ATG14,OSBPL8,SEMA4B,SH2B3,STAB1,ASCC3,PREX1,PTPRC,RHBDF2,DOCK8,DOCK2,VMP1,VAV3,PPFIBP2,SLC16A10,TMTC1,ATP10D,ACER2,NACC2,GAB1,KREMEN1,TFEB,DAB2,BLVRA,DIAPH2,PREX2
8.870e-04	-7.03	receptor-mediated endocytosis	biological process	GO:0006898	163	4	18204	48	DAB2,SYK,FCHO2,STAB1
8.881e-04	-7.03	RhoGEF	pfam domains	PF00621	70	3	17795	48	VAV3,PREX1,PREX2
8.887e-04	-7.03	regulation of biological quality	biological process	GO:0065008	2936	17	18204	48	ATG14,VAV3,SH2B3,ENTPD1,PREX1,PLXND1,PTGIR,PTPN6,DISC1,ATP10D,SYK,VMP1,SLC9A1,RBM47,SLC16A10,DAB2,HCK
8.917e-04	-7.02	-	gene3d domains	2.30.42.10	149	4	14470	42	PREX2,PREX1,MPP1,RAPGEF6
9.137e-04	-7.00	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	2	18094	48	PTPN6,PTPRC
9.137e-04	-7.00	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	2	18094	48	PTPRC,PTPN6
9.267e-04	-6.98	positive regulation of molecular function	biological process	GO:0044093	1192	10	18204	48	VMP1,PREX2,SLC9A1,CEMIP,RAPGEF6,SYK,PTPRC,DOCK8,PREX1,ACER2
9.341e-04	-6.98	RHOJ (ras homolog family member J)	protein interactions	57381	628	7	19454	49	FCHO2,SLC9A1,OSBPL8,DOCK8,GAB1,VMP1,DIAPH2
9.376e-04	-6.97	PH_DOMAIN	prosite domains	PS50003	246	5	12186	38	OSBPL8,GAB1,PREX1,PREX2,VAV3
9.452e-04	-6.96	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	6	19454	49	SH2B3,GAB1,HCK,SYK,PTPN6,PTPRC
9.845e-04	-6.92	PDZ	prosite domains	PS50106	143	4	12186	38	RAPGEF6,PREX2,PREX1,MPP1
1.014e-03	-6.89	regulation of clathrin-dependent endocytosis	biological process	GO:2000369	18	2	18204	48	BMP2K,DAB2
1.014e-03	-6.89	clathrin coat assembly	biological process	GO:0048268	18	2	18204	48	FCHO2,DAB2
1.014e-03	-6.89	gamma-delta T cell activation	biological process	GO:0046629	18	2	18204	48	SYK,PTPRC
1.014e-03	-6.89	regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002923	18	2	18204	48	PTPRC,PTPN6
1.015e-03	-6.89	clathrin-coated pit	cellular component	GO:0005905	77	3	19108	49	DAB2,FCHO2,CEMIP
1.015e-03	-6.89	negative regulation of defense response	biological process	GO:0031348	293	5	18204	48	PTPN6,RHBDF2,SYK,PTPRC,HCK
1.019e-03	-6.89	regulation of response to stress	biological process	GO:0080134	1431	11	18204	48	SYK,PTPRC,PTPN6,NACC2,KREMEN1,RBM47,CADM4,SH2B3,RHBDF2,HCK,ACACB
1.037e-03	-6.87	negative regulation of MAPK cascade	biological process	GO:0043409	170	4	18204	48	DAB2,PTPRC,SH2B3,PTPN6
1.037e-03	-6.87	regulation of calcium ion transmembrane transport	biological process	GO:1903169	170	4	18204	48	SLC9A1,VMP1,PTPN6,CEMIP
1.040e-03	-6.87	cell junction	cellular component	GO:0030054	2224	14	19108	49	PTPRC,DAB2,PTPN6,SEMA4B,GAB1,CADM4,SLC16A10,DISC1,PPFIBP2,FCHO2,PLXND1,SLC9A1,MPP1,HCK
1.061e-03	-6.85	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	10	16828	46	DOCK2,SYK,PREX2,DIAPH2,SH2B3,SLC16A10,GRK6,BMP2K,HCK,GAB1
1.061e-03	-6.85	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	10	16828	46	GAB1,HCK,BMP2K,SLC16A10,GRK6,SH2B3,DIAPH2,PREX2,SYK,DOCK2
1.095e-03	-6.82	Regulation of KIT signaling	REACTOME pathways	R-HSA-1433559	16	2	10285	32	PTPN6,SH2B3
1.113e-03	-6.80	positive regulation of cell motility	biological process	GO:2000147	619	7	18204	48	SEMA4B,CEMIP,DOCK8,PTPRC,GAB1,DAB2,PREX1
1.133e-03	-6.78	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	3	14470	42	PREX2,VAV3,PREX1
1.161e-03	-6.76	immune response-activating signaling pathway	biological process	GO:0002757	302	5	18204	48	VAV3,HCK,PTPN6,SYK,PTPRC
1.164e-03	-6.76	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	12	18204	48	GAB1,VAV3,PLXND1,ACACB,SYK,PTPRC,DISC1,DOCK8,PTPN6,SLC9A1,RBM47,DAB2
1.179e-03	-6.74	blood coagulation	biological process	GO:0007596	176	4	18204	48	PTPN6,ENTPD1,SYK,VAV3
1.183e-03	-6.74	STX7 (syntaxin 7)	protein interactions	8417	654	7	19454	49	OSBPL8,GAB1,VMP1,BMP2K,FCHO2,DAB2,SLC9A1
1.197e-03	-6.73	EPO signaling pathway	Pathway Interaction DB	epopathway	33	3	2226	15	PTPN6,GAB1,SH2B3
1.229e-03	-6.70	coagulation	biological process	GO:0050817	178	4	18204	48	VAV3,ENTPD1,PTPN6,SYK
1.233e-03	-6.70	regulation of cell activation	biological process	GO:0050865	630	7	18204	48	VAV3,SH2B3,PTPN6,DOCK8,TMEM131L,PTPRC,SYK
1.239e-03	-6.69	Hyaluronan metabolism	REACTOME pathways	R-HSA-2142845	17	2	10285	32	CEMIP,SLC9A1
1.255e-03	-6.68	regulation of response to wounding	biological process	GO:1903034	179	4	18204	48	CADM4,PTPN6,SH2B3,KREMEN1
1.267e-03	-6.67	positive regulation of locomotion	biological process	GO:0040017	633	7	18204	48	PTPRC,GAB1,DOCK8,CEMIP,SEMA4B,PREX1,DAB2
1.283e-03	-6.66	ZAP70 (zeta chain of T cell receptor associated protein kinase 70)	protein interactions	7535	85	3	19454	49	PTPRC,SH2B3,PTPN6
1.287e-03	-6.66	CXCR4-mediated signaling events	Pathway Interaction DB	cxcr4_pathway	76	4	2226	15	PTPN6,GRK6,PTPRC,HCK
1.313e-03	-6.64	RAC2 (Rac family small GTPase 2)	protein interactions	5880	666	7	19454	49	DOCK2,SLC9A1,FCHO2,OSBPL8,VMP1,DIAPH2,DAB2
1.317e-03	-6.63	granulocyte chemotaxis	biological process	GO:0071621	82	3	18204	48	SYK,PREX1,VAV3
1.321e-03	-6.63	PDZ	smart domains	SM00228	143	4	9717	33	PREX2,RAPGEF6,MPP1,PREX1
1.326e-03	-6.63	DH_2	prosite domains	PS50010	70	3	12186	38	PREX1,PREX2,VAV3
1.334e-03	-6.62	T cell differentiation	biological process	GO:0030217	182	4	18204	48	SYK,DOCK2,PTPRC,PREX1
1.334e-03	-6.62	stem cell differentiation	biological process	GO:0048863	182	4	18204	48	SH2B3,SEMA4B,PTPRC,SLC9A1
1.334e-03	-6.62	hemostasis	biological process	GO:0007599	182	4	18204	48	VAV3,SYK,PTPN6,ENTPD1
1.338e-03	-6.62	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	35	16828	46	DOCK8,DOCK2,VMP1,VAV3,PPFIBP2,PTGIR,RHBDF2,HCK,PREX1,ASCC3,PTPRC,DIAPH2,PREX2,KREMEN1,TFEB,DAB2,ATP10D,MPP1,ACER2,CADM4,PTPN6,GAB1,SLC16A10,TMTC1,ENTPD1,ACACB,STAB1,SYK,GALNT1,RAPGEF6,PLXND1,GRK6,RBM47,PPP1R7,ATG14
1.362e-03	-6.60	regulation of lipid localization	biological process	GO:1905952	183	4	18204	48	ACACB,DAB2,SYK,OSBPL8
1.363e-03	-6.60	positive regulation of calcium ion transmembrane transport	biological process	GO:1904427	83	3	18204	48	VMP1,SLC9A1,CEMIP
1.363e-03	-6.60	positive regulation of B cell activation	biological process	GO:0050871	83	3	18204	48	PTPRC,SYK,VAV3
1.372e-03	-6.59	FGR (FGR proto-oncogene, Src family tyrosine kinase)	protein interactions	2268	87	3	19454	49	DAB2,SYK,HCK
1.385e-03	-6.58	thymic T cell selection	biological process	GO:0045061	21	2	18204	48	PTPRC,DOCK2
1.390e-03	-6.58	FCGR2B (Fc gamma receptor IIb)	protein interactions	2213	22	2	19454	49	PTPN6,GAB1
1.391e-03	-6.58	Regulation of signaling by CBL	REACTOME pathways	R-HSA-912631	18	2	10285	32	SYK,HCK
1.440e-03	-6.54	lamellipodium membrane	cellular component	GO:0031258	22	2	19108	49	PLXND1,DOCK8
1.448e-03	-6.54	DEP	pfam domains	PF00610	21	2	17795	48	PREX2,PREX1
1.465e-03	-6.53	SLC25A41 (solute carrier family 25 member 41)	protein interactions	284427	89	3	19454	49	FCHO2,DAB2,BMP2K
1.499e-03	-6.50	lymphocyte activation	biological process	GO:0046649	476	6	18204	48	PTPN6,PTPRC,SYK,DOCK8,PREX1,DOCK2
1.499e-03	-6.50	positive regulation of transport	biological process	GO:0051050	844	8	18204	48	DAB2,DOCK2,SLC9A1,VMP1,SYK,PTPRC,OSBPL8,CEMIP
1.508e-03	-6.50	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	17	16828	46	TFEB,SYK,KREMEN1,OSBPL8,PLXND1,PPP1R7,RBM47,RAPGEF6,GAB1,PTPN6,PPFIBP2,VAV3,VMP1,TMCC3,PTPRC,ACACB,PTGIR
1.508e-03	-6.50	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	17	16828	46	SYK,KREMEN1,TFEB,OSBPL8,RBM47,PLXND1,PPP1R7,GAB1,PTPN6,RAPGEF6,VAV3,PPFIBP2,VMP1,TMCC3,PTPRC,ACACB,PTGIR
1.514e-03	-6.49	signaling receptor binding	molecular function	GO:0005102	1493	11	18094	48	SEMA4B,VAV3,DOCK2,DIAPH2,MPP1,DAB2,SH2B3,PTPRC,CADM4,HCK,SYK
1.521e-03	-6.49	positive regulation of cell adhesion mediated by integrin	biological process	GO:0033630	22	2	18204	48	PTPN6,SYK
1.531e-03	-6.48	DEP_dom	interpro domains	IPR000591	22	2	18521	49	PREX2,PREX1
1.539e-03	-6.48	RhoGEF	smart domains	SM00325	68	3	9717	33	VAV3,PREX2,PREX1
1.552e-03	-6.47	Other semaphorin interactions	REACTOME pathways	R-HSA-416700	19	2	10285	32	PTPRC,PLXND1
1.561e-03	-6.46	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	3	19454	49	PTPN6,GAB1,HCK
1.566e-03	-6.46	ERBB3 (erb-b2 receptor tyrosine kinase 3)	protein interactions	2065	338	5	19454	49	VAV3,PTPN6,SH2B3,HCK,SYK
1.662e-03	-6.40	UTP25 (UTP25 small subunit processome component)	protein interactions	27042	93	3	19454	49	PREX1,BMP2K,GRK6
1.663e-03	-6.40	megakaryocyte development	biological process	GO:0035855	23	2	18204	48	PTPN6,SH2B3
1.672e-03	-6.39	positive regulation of lymphocyte activation	biological process	GO:0051251	328	5	18204	48	VAV3,PTPN6,DOCK8,SYK,PTPRC
1.692e-03	-6.38	INSR (insulin receptor)	protein interactions	3643	344	5	19454	49	PTPRC,VAV3,OSBPL8,PTPN6,GAB1
1.714e-03	-6.37	ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase)	protein interactions	6098	94	3	19454	49	PTPN6,OSBPL8,VAV3
1.723e-03	-6.36	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	45	16828	46	TMTC1,ATP10D,PTPN6,NACC2,GAB1,DISC1,DIAPH2,BLVRA,PTPRC,ASCC3,HCK,FCHO2,DOCK8,PPFIBP2,SMOX,PLXND1,RBM47,PPP1R7,OSBPL8,RAPGEF6,SYK,STAB1,ENTPD1,SLC16A10,ACER2,MPP1,CADM4,TFEB,KREMEN1,DAB2,PREX2,PREX1,BMP2K,PTGIR,RHBDF2,VMP1,DOCK2,VAV3,GRK6,SLC9A1,ATG14,GALNT1,SEMA4B,ACACB,TMCC3
1.723e-03	-6.36	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	45	16828	46	ENTPD1,SYK,STAB1,RBM47,PLXND1,PPP1R7,OSBPL8,RAPGEF6,DOCK8,FCHO2,PPFIBP2,SMOX,ASCC3,PTPRC,HCK,DISC1,DIAPH2,BLVRA,TMTC1,ATP10D,NACC2,PTPN6,GAB1,TMCC3,ACACB,GALNT1,SEMA4B,SLC9A1,GRK6,ATG14,DOCK2,VMP1,VAV3,PREX1,BMP2K,PTGIR,RHBDF2,KREMEN1,TFEB,DAB2,PREX2,SLC16A10,MPP1,ACER2,CADM4
1.735e-03	-6.36	regulation of multicellular organismal process	biological process	GO:0051239	3113	17	18204	48	SLC9A1,SYK,PTPRC,DISC1,TMEM131L,DOCK8,PTPN6,DAB2,RBM47,BMP2K,VAV3,KREMEN1,GAB1,STAB1,ACACB,PLXND1,SH2B3
1.745e-03	-6.35	cellular response to stimulus	biological process	GO:0051716	6307	27	18204	48	TMEM131L,SMOX,GRK6,DAB2,HCK,GAB1,TFEB,ATG14,MPP1,SH2B3,PREX1,ACER2,DISC1,PTPRC,SYK,DOCK8,PTPN6,SLC9A1,PREX2,DOCK2,SEMA4B,RAPGEF6,VAV3,KREMEN1,PTGIR,ASCC3,PLXND1
1.759e-03	-6.34	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	7	16828	46	PREX2,STAB1,SYK,BMP2K,RHBDF2,HCK,GRK6
1.775e-03	-6.33	regulation of localization	biological process	GO:0032879	2028	13	18204	48	CEMIP,BMP2K,ACACB,PTPN6,OSBPL8,SYK,PTPRC,VMP1,SLC9A1,RHBDF2,DOCK2,DAB2,HCK
1.790e-03	-6.33	positive regulation of catalytic activity	biological process	GO:0043085	868	8	18204	48	SYK,PTPRC,DOCK8,CEMIP,RAPGEF6,PREX2,PREX1,ACER2
1.796e-03	-6.32	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	30	16828	46	GAB1,ATP10D,MPP1,ACER2,TMTC1,SLC16A10,DIAPH2,BLVRA,PREX2,DAB2,KREMEN1,ASCC3,PREX1,PTPRC,SMOX,VAV3,PPFIBP2,DOCK8,DOCK2,VMP1,OSBPL8,ATG14,SLC9A1,SH2B3,STAB1,SEMA4B,GALNT1,ACACB,TMCC3,ENTPD1
1.797e-03	-6.32	ZHX1-C8orf76 (ZHX1-C8orf76 readthrough)	protein interactions	100533106	25	2	19454	49	PHKB,DISC1
1.875e-03	-6.28	human chr1q31.3-q32.1	chromosome location	human chr1q31.3-q32.1	1	1	26134	49	PTPRC
1.904e-03	-6.26	regulation of cell population proliferation	biological process	GO:0042127	1790	12	18204	48	PTPN6,TMEM131L,DISC1,PTPRC,NACC2,HCK,DAB2,VAV3,SH2B3,CADM4,ACER2,PTGIR
1.915e-03	-6.26	DEP	prosite domains	PS50186	21	2	12186	38	PREX2,PREX1
1.922e-03	-6.25	regulation of cell-cell adhesion	biological process	GO:0022407	500	6	18204	48	SH2B3,PTPN6,DOCK8,PTPRC,SYK,TMEM131L
1.923e-03	-6.25	phosphoprotein binding	molecular function	GO:0051219	93	3	18094	48	PTPN6,HCK,SYK
1.924e-03	-6.25	HRAS (HRas proto-oncogene, GTPase)	protein interactions	3265	712	7	19454	49	DOCK8,GAB1,FCHO2,SLC9A1,PPFIBP2,RAPGEF6,MPP1
1.925e-03	-6.25	enzyme regulator activity	molecular function	GO:0030234	1305	10	18094	48	PREX2,PREX1,PTGIR,PPP1R7,DOCK2,VAV3,ATG14,DOCK8,BMP2K,RAPGEF6
1.928e-03	-6.25	anchoring junction	cellular component	GO:0070161	902	8	19108	49	DAB2,PTPRC,MPP1,SLC9A1,PTPN6,CADM4,HCK,GAB1
1.940e-03	-6.25	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	7	19454	49	HCK,GAB1,PTPN6,SYK,PTPRC,MPP1,FCHO2
1.949e-03	-6.24	endocytic vesicle	cellular component	GO:0030139	349	5	19108	49	STAB1,RAPGEF6,SYK,CEMIP,ATG14
1.965e-03	-6.23	Fc-epsilon receptor signaling pathway	biological process	GO:0038095	25	2	18204	48	SYK,VAV3
1.988e-03	-6.22	Flnb (filamin, beta)	protein interactions	286940	99	3	19454	49	DAB2,FCHO2,BMP2K
2.021e-03	-6.20	regulation of lymphocyte activation	biological process	GO:0051249	505	6	18204	48	VAV3,TMEM131L,SYK,PTPRC,DOCK8,PTPN6
2.041e-03	-6.19	hemopoiesis	biological process	GO:0030097	688	7	18204	48	PTPN6,SYK,PTPRC,SH2B3,DOCK2,RBM47,PREX1
2.070e-03	-6.18	negative regulation of response to wounding	biological process	GO:1903035	96	3	18204	48	SH2B3,PTPN6,KREMEN1
2.070e-03	-6.18	granulocyte migration	biological process	GO:0097530	96	3	18204	48	VAV3,PREX1,SYK
2.095e-03	-6.17	CD72 (CD72 molecule)	protein interactions	971	27	2	19454	49	SYK,PTPN6
2.095e-03	-6.17	SLA (Src like adaptor)	protein interactions	6503	27	2	19454	49	SYK,GAB1
2.095e-03	-6.17	OLIG1 (oligodendrocyte transcription factor 1)	protein interactions	116448	27	2	19454	49	HCK,PTPN6
2.096e-03	-6.17	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	14	16828	46	VMP1,DOCK8,DOCK2,ENTPD1,TMCC3,PTGIR,STAB1,SLC9A1,PLXND1,ATG14,TMTC1,ATP10D,RAPGEF6,PTPN6
2.104e-03	-6.16	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	3	19454	49	RHBDF2,CADM4,PTPN6
2.125e-03	-6.15	membrane raft organization	biological process	GO:0031579	26	2	18204	48	DOCK2,PTPRC
2.150e-03	-6.14	hyaluronic acid binding	molecular function	GO:0005540	26	2	18094	48	STAB1,CEMIP
2.170e-03	-6.13	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	10	16828	46	STAB1,PREX2,DISC1,TFEB,DOCK8,SYK,DOCK2,CADM4,PTPRC,RBM47
2.252e-03	-6.10	regulation of vesicle-mediated transport	biological process	GO:0060627	516	6	18204	48	HCK,DAB2,DOCK2,BMP2K,SYK,PTPRC
2.253e-03	-6.10	WDR53 (WD repeat domain 53)	protein interactions	348793	28	2	19454	49	ACACB,BLVRA
2.256e-03	-6.09	DEP	smart domains	SM00049	21	2	9717	33	PREX2,PREX1
2.260e-03	-6.09	phospholipid transport	biological process	GO:0015914	99	3	18204	48	ATP10D,OSBPL8,VMP1
2.272e-03	-6.09	regulation of response to external stimulus	biological process	GO:0032101	1116	9	18204	48	PTPN6,PTPRC,SYK,KREMEN1,MPP1,RHBDF2,SH2B3,RBM47,HCK
2.291e-03	-6.08	positive regulation of GTPase activity	biological process	GO:0043547	211	4	18204	48	PREX2,PREX1,RAPGEF6,DOCK8
2.339e-03	-6.06	SFTPC (surfactant protein C)	protein interactions	6440	222	4	19454	49	PLXND1,TMEM131L,CADM4,SEMA4B
2.350e-03	-6.05	Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME pathways	R-HSA-2029480	86	3	10285	32	SYK,HCK,VAV3
2.363e-03	-6.05	SH3-like_dom_sf	interpro domains	IPR036028	212	4	18521	49	HCK,DOCK2,VAV3,MPP1
2.389e-03	-6.04	regulation of body fluid levels	biological process	GO:0050878	356	5	18204	48	ENTPD1,PTPN6,SH2B3,SYK,VAV3
2.411e-03	-6.03	positive regulation of transmembrane transport	biological process	GO:0034764	214	4	18204	48	SLC9A1,VMP1,CEMIP,OSBPL8
2.411e-03	-6.03	negative regulation of cell activation	biological process	GO:0050866	214	4	18204	48	TMEM131L,PTPRC,SH2B3,PTPN6
2.416e-03	-6.03	NMUR2 (neuromedin U receptor 2)	protein interactions	56923	29	2	19454	49	OSBPL8,VMP1
2.416e-03	-6.03	CD5 (CD5 molecule)	protein interactions	921	29	2	19454	49	PPP1R7,PTPN6
2.422e-03	-6.02	positive regulation of signal transduction	biological process	GO:0009967	1593	11	18204	48	VAV3,NACC2,SLC9A1,BMP2K,PTPN6,OSBPL8,DISC1,PTPRC,SYK,DAB2,RBM47
2.460e-03	-6.01	B cell receptor signaling pathway	KEGG pathways	hsa04662	70	3	7161	28	VAV3,SYK,PTPN6
2.460e-03	-6.01	B cell receptor signaling pathway	KEGG pathways	ko04662	70	3	7161	28	VAV3,SYK,PTPN6
2.460e-03	-6.01	alpha-beta T cell activation	biological process	GO:0046631	102	3	18204	48	PTPRC,SYK,DOCK2
2.480e-03	-6.00	RPL39 (ribosomal protein L39)	protein interactions	6170	107	3	19454	49	VMP1,PTPN6,SYK
2.481e-03	-6.00	Plexin_repeat	interpro domains	IPR002165	28	2	18521	49	PLXND1,SEMA4B
2.487e-03	-6.00	NAHEXCHNGR1	prints domains	PR01085	1	1	5227	13	SLC9A1
2.487e-03	-6.00	PRSTNOIDIPR	prints domains	PR00856	1	1	5227	13	PTGIR
2.493e-03	-5.99	regulation of lymphocyte differentiation	biological process	GO:0045619	216	4	18204	48	PTPN6,PTPRC,TMEM131L,SYK
2.493e-03	-5.99	cell chemotaxis	biological process	GO:0060326	216	4	18204	48	VAV3,PREX1,SYK,GAB1
2.495e-03	-5.99	PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)	protein interactions	5296	226	4	19454	49	SYK,STAB1,HCK,GAB1
2.519e-03	-5.98	Tfap2a (transcription factor AP-2 alpha)	protein interactions	306862	1	1	19454	49	DAB2
2.519e-03	-5.98	ACER2 (alkaline ceramidase 2)	protein interactions	340485	1	1	19454	49	MPP1
2.519e-03	-5.98	PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)	protein interactions	103222505	1	1	19454	49	ATG14
2.519e-03	-5.98	BECN1 (beclin 1)	protein interactions	103243387	1	1	19454	49	ATG14
2.519e-03	-5.98	NTA1 (amidase)	protein interactions	853525	1	1	19454	49	DOCK8
2.519e-03	-5.98	ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)	protein interactions	103239106	1	1	19454	49	VMP1
2.519e-03	-5.98	EUC1 (Euc1p)	protein interactions	855138	1	1	19454	49	DOCK8
2.550e-03	-5.97	negative regulation of immune system process	biological process	GO:0002683	529	6	18204	48	RHBDF2,HCK,PTPN6,SYK,PTPRC,TMEM131L
2.564e-03	-5.97	extrinsic component of phagophore assembly site membrane	cellular component	GO:0097632	1	1	19108	49	ATG14
2.568e-03	-5.96	positive regulation of leukocyte activation	biological process	GO:0002696	362	5	18204	48	DOCK8,SYK,PTPRC,PTPN6,VAV3
2.575e-03	-5.96	PSI	pfam domains	PF01437	28	2	17795	48	SEMA4B,PLXND1
2.584e-03	-5.96	PECAM1 (platelet and endothelial cell adhesion molecule 1)	protein interactions	5175	30	2	19454	49	PTPN6,HCK
2.584e-03	-5.96	CSF3R (colony stimulating factor 3 receptor)	protein interactions	1441	30	2	19454	49	SYK,HCK
2.584e-03	-5.96	AP4S1 (adaptor related protein complex 4 subunit sigma 1)	protein interactions	11154	30	2	19454	49	SLC9A1,DISC1
2.617e-03	-5.95	SPPL2B (signal peptide peptidase like 2B)	protein interactions	56928	229	4	19454	49	GALNT1,VMP1,CADM4,OSBPL8
2.637e-03	-5.94	lactic acid secretion	biological process	GO:0046722	1	1	18204	48	ACACB
2.637e-03	-5.94	leading edge cell differentiation	biological process	GO:0035026	1	1	18204	48	DAB2
2.637e-03	-5.94	plasma membrane raft distribution	biological process	GO:0044855	1	1	18204	48	PTPRC
2.637e-03	-5.94	plasma membrane raft localization	biological process	GO:0044856	1	1	18204	48	PTPRC
2.637e-03	-5.94	intracellular aspartate homeostasis	biological process	GO:0090459	1	1	18204	48	ACACB
2.637e-03	-5.94	positive regulation of interleukin-3 production	biological process	GO:0032752	1	1	18204	48	SYK
2.637e-03	-5.94	memory T cell proliferation	biological process	GO:0061485	1	1	18204	48	DOCK8
2.641e-03	-5.94	regulation of platelet aggregation	biological process	GO:0090330	29	2	18204	48	SYK,SH2B3
2.646e-03	-5.93	VAV3_SH2	interpro domains	IPR035881	1	1	18521	49	VAV3
2.646e-03	-5.93	Ptprc	interpro domains	IPR016335	1	1	18521	49	PTPRC
2.646e-03	-5.93	Biliverdin_Rdtase_A	interpro domains	IPR017094	1	1	18521	49	BLVRA
2.646e-03	-5.93	SH2B3_SH2	interpro domains	IPR035059	1	1	18521	49	SH2B3
2.646e-03	-5.93	DHR2_DOCK2	interpro domains	IPR026799	1	1	18521	49	DOCK2
2.646e-03	-5.93	RBM47_RRM1	interpro domains	IPR047044	1	1	18521	49	RBM47
2.646e-03	-5.93	MPP1_SH3	interpro domains	IPR035475	1	1	18521	49	MPP1
2.646e-03	-5.93	VAV3_SH3_2	interpro domains	IPR035734	1	1	18521	49	VAV3
2.646e-03	-5.93	Plexin-D1_Sema	interpro domains	IPR042719	1	1	18521	49	PLXND1
2.646e-03	-5.93	PTP_recept_N	interpro domains	IPR024739	1	1	18521	49	PTPRC
2.646e-03	-5.93	HCK_SH2	interpro domains	IPR035851	1	1	18521	49	HCK
2.646e-03	-5.93	BMP2K_C	interpro domains	IPR028182	1	1	18521	49	BMP2K
2.646e-03	-5.93	FCHo2_F-BAR	interpro domains	IPR030122	1	1	18521	49	FCHO2
2.646e-03	-5.93	RBM47_RRM3	interpro domains	IPR034445	1	1	18521	49	RBM47
2.646e-03	-5.93	DISC1	interpro domains	IPR026081	1	1	18521	49	DISC1
2.646e-03	-5.93	Biliverdin_Rdtase_cat	interpro domains	IPR015249	1	1	18521	49	BLVRA
2.646e-03	-5.93	NHE-1-like	interpro domains	IPR001970	1	1	18521	49	SLC9A1
2.646e-03	-5.93	RBM47_RRM2	interpro domains	IPR034440	1	1	18521	49	RBM47
2.646e-03	-5.93	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	49	PREX2
2.646e-03	-5.93	Prostglndn_IP_rcpt	interpro domains	IPR000370	1	1	18521	49	PTGIR
2.646e-03	-5.93	bHLHzip_TFEB	interpro domains	IPR024098	1	1	18521	49	TFEB
2.646e-03	-5.93	VAV3_SH3_1	interpro domains	IPR047015	1	1	18521	49	VAV3
2.653e-03	-5.93	ITPase activity	molecular function	GO:0103023	1	1	18094	48	ENTPD1
2.653e-03	-5.93	norspermine:oxygen oxidoreductase activity	molecular function	GO:0052894	1	1	18094	48	SMOX
2.653e-03	-5.93	prostacyclin receptor activity	molecular function	GO:0016501	1	1	18094	48	PTGIR
2.653e-03	-5.93	L-tyrosine transmembrane transporter activity	molecular function	GO:0005302	1	1	18094	48	SLC16A10
2.653e-03	-5.93	sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential	molecular function	GO:0086040	1	1	18094	48	SLC9A1
2.653e-03	-5.93	interleukin-15 receptor binding	molecular function	GO:0016170	1	1	18094	48	SYK
2.653e-03	-5.93	N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity	molecular function	GO:0052895	1	1	18094	48	SMOX
2.664e-03	-5.93	regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050730	220	4	18204	48	PTPN6,SYK,CADM4,PTPRC
2.697e-03	-5.92	BMP2K_C	pfam domains	PF15282	1	1	17795	48	BMP2K
2.697e-03	-5.92	CD45	pfam domains	PF12567	1	1	17795	48	PTPRC
2.697e-03	-5.92	PTP_N	pfam domains	PF12453	1	1	17795	48	PTPRC
2.697e-03	-5.92	Biliv-reduc_cat	pfam domains	PF09166	1	1	17795	48	BLVRA
2.721e-03	-5.91	seminoma	COSMIC cancer mutations	seminoma	700	7	16828	46	PREX2,STAB1,SYK,BMP2K,RHBDF2,HCK,GRK6
2.757e-03	-5.89	activation of immune response	biological process	GO:0002253	368	5	18204	48	HCK,VAV3,PTPN6,PTPRC,SYK
2.757e-03	-5.89	immune response-regulating signaling pathway	biological process	GO:0002764	368	5	18204	48	VAV3,HCK,SYK,PTPRC,PTPN6
2.758e-03	-5.89	SEMA4D (semaphorin 4D)	protein interactions	10507	31	2	19454	49	SEMA4B,PTPRC
2.758e-03	-5.89	ADISSP (adipose secreted signaling protein)	protein interactions	54976	31	2	19454	49	PHKB,PPP1R7
2.791e-03	-5.88	SH3_domain	interpro domains	IPR001452	222	4	18521	49	HCK,DOCK2,VAV3,MPP1
2.792e-03	-5.88	Hemostasis	REACTOME pathways	R-HSA-109582	632	7	10285	32	SYK,SH2B3,PTPN6,DOCK2,DOCK8,PTGIR,VAV3
2.825e-03	-5.87	megakaryocyte differentiation	biological process	GO:0030219	30	2	18204	48	SH2B3,PTPN6
2.949e-03	-5.83	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	3	16828	46	NACC2,ATP10D,DOCK2
2.953e-03	-5.82	Sema	pfam domains	PF01403	30	2	17795	48	PLXND1,SEMA4B
2.957e-03	-5.82	RHOD (ras homolog family member D)	protein interactions	29984	570	6	19454	49	FCHO2,SLC9A1,DAB2,DIAPH2,OSBPL8,GAB1
2.965e-03	-5.82	Thromboxane A2 receptor signaling	Pathway Interaction DB	txa2pathway	45	3	2226	15	PTGIR,HCK,SYK
2.966e-03	-5.82	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	7	19454	49	PTPRC,VAV3,PTPN6,DAB2,SYK,GAB1,SH2B3
2.980e-03	-5.82	cell adhesion	biological process	GO:0007155	942	8	18204	48	VMP1,PTPN6,STAB1,PTPRC,SYK,HCK,ENTPD1,CADM4
2.983e-03	-5.81	CKAP4 (cytoskeleton associated protein 4)	protein interactions	10970	571	6	19454	49	VAV3,VMP1,DISC1,OSBPL8,TMEM131L,RHBDF2
2.983e-03	-5.81	cell-cell adhesion	biological process	GO:0098609	546	6	18204	48	VMP1,SYK,PTPRC,PTPN6,CADM4,ENTPD1
3.007e-03	-5.81	regulation of catalytic activity	biological process	GO:0050790	1395	10	18204	48	PREX2,VAV3,DOCK8,PTPRC,SYK,RAPGEF6,CEMIP,ACER2,PREX1,PLXND1
3.015e-03	-5.80	positive regulation of calcium ion transmembrane transporter activity	biological process	GO:1901021	31	2	18204	48	SLC9A1,VMP1
3.015e-03	-5.80	neutrophil activation	biological process	GO:0042119	31	2	18204	48	PREX1,SYK
3.036e-03	-5.80	Semap_dom	interpro domains	IPR001627	31	2	18521	49	PLXND1,SEMA4B
3.036e-03	-5.80	Semap_dom_sf	interpro domains	IPR036352	31	2	18521	49	SEMA4B,PLXND1
3.048e-03	-5.79	PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)	protein interactions	5295	394	5	19454	49	SYK,PTPN6,GAB1,HCK,VAV3
3.102e-03	-5.78	large_cell	COSMIC cancer mutations	large_cell	14845	46	16828	46	PREX1,BMP2K,PTGIR,RHBDF2,DOCK2,VMP1,VAV3,SLC16A10,ACER2,MPP1,CADM4,KREMEN1,TFEB,DAB2,PREX2,ACACB,TMCC3,SLC9A1,GRK6,ATG14,GALNT1,SEMA4B,SH2B3,ASCC3,PTPRC,HCK,DOCK8,FCHO2,PPFIBP2,SMOX,TMTC1,ATP10D,PTPN6,GAB1,NACC2,DISC1,BLVRA,DIAPH2,ENTPD1,PPP1R7,RBM47,PLXND1,OSBPL8,RAPGEF6,SYK,STAB1
3.109e-03	-5.77	TOP3B (DNA topoisomerase III beta)	protein interactions	8940	1465	10	19454	49	SEMA4B,RBM47,RAPGEF6,GRK6,PLXND1,PREX1,DIAPH2,RHBDF2,TFEB,SH2B3
3.194e-03	-5.75	PTGER3 (prostaglandin E receptor 3)	protein interactions	5733	117	3	19454	49	OSBPL8,RHBDF2,SLC9A1
3.200e-03	-5.74	positive regulation of cell activation	biological process	GO:0050867	381	5	18204	48	VAV3,DOCK8,SYK,PTPRC,PTPN6
3.240e-03	-5.73	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	26	16828	46	HCK,RHBDF2,PTPRC,PREX1,ASCC3,SMOX,DOCK8,DOCK2,PPFIBP2,VAV3,MPP1,ATP10D,NACC2,GAB1,TMTC1,PREX2,KREMEN1,DAB2,ACACB,ENTPD1,TMCC3,RAPGEF6,PLXND1,GRK6,SEMA4B,STAB1
3.271e-03	-5.72	HLA-G (major histocompatibility complex, class I, G)	protein interactions	3135	118	3	19454	49	OSBPL8,CADM4,TMEM131L
3.305e-03	-5.71	ERBB2 (erb-b2 receptor tyrosine kinase 2)	protein interactions	2064	583	6	19454	49	VAV3,SYK,SH2B3,PTPN6,GAB1,HCK
3.309e-03	-5.71	regulation of T cell activation	biological process	GO:0050863	384	5	18204	48	PTPN6,DOCK8,TMEM131L,PTPRC,SYK
3.309e-03	-5.71	regulation of leukocyte cell-cell adhesion	biological process	GO:1903037	384	5	18204	48	DOCK8,TMEM131L,SYK,PTPRC,PTPN6
3.312e-03	-5.71	ELMO1 (engulfment and cell motility 1)	protein interactions	9844	34	2	19454	49	DOCK2,HCK
3.321e-03	-5.71	OTULINL (OTU deubiquitinase with linear linkage specificity like)	protein interactions	54491	402	5	19454	49	VMP1,PPP1R7,SLC9A1,TMEM131L,OSBPL8
3.335e-03	-5.70	ITSN1 (intersectin 1)	protein interactions	6453	245	4	19454	49	PREX1,FCHO2,DISC1,DAB2
3.430e-03	-5.68	CD79B (CD79b molecule)	protein interactions	974	120	3	19454	49	PTPRC,PTPN6,SYK
3.479e-03	-5.66	regulation of lymphocyte proliferation	biological process	GO:0050670	237	4	18204	48	TMEM131L,PTPRC,PTPN6,VAV3
3.484e-03	-5.66	SYK (spleen associated tyrosine kinase)	protein interactions	6850	248	4	19454	49	OSBPL8,GAB1,PTPN6,SYK
3.497e-03	-5.66	immune effector process	biological process	GO:0002252	389	5	18204	48	VAV3,HCK,DOCK2,SYK,PTPN6
3.507e-03	-5.65	IL2RB (interleukin 2 receptor subunit beta)	protein interactions	3560	35	2	19454	49	SYK,PTPN6
3.516e-03	-5.65	testis	COSMIC cancer mutations	testis	733	7	16828	46	BMP2K,HCK,RHBDF2,GRK6,PREX2,STAB1,SYK
3.540e-03	-5.64	Nanoparticle triggered autophagic cell death	WikiPathways	WP2509	24	2	5310	20	VMP1,ATG14
3.593e-03	-5.63	FLNA (filamin A)	protein interactions	2316	593	6	19454	49	SYK,SH2B3,DAB2,VMP1,DISC1,BMP2K
3.613e-03	-5.62	The role of Nef in HIV-1 replication and disease pathogenesis	REACTOME pathways	R-HSA-164952	29	2	10285	32	HCK,DOCK2
3.615e-03	-5.62	LRRC59 (leucine rich repeat containing 59)	protein interactions	55379	797	7	19454	49	ASCC3,TMCC3,RHBDF2,TMEM131L,OSBPL8,DOCK8,VMP1
3.619e-03	-5.62	positive T cell selection	biological process	GO:0043368	34	2	18204	48	PTPRC,DOCK2
3.619e-03	-5.62	regulation of B cell differentiation	biological process	GO:0045577	34	2	18204	48	SYK,PTPN6
3.621e-03	-5.62	PRTYPHPHTASE	prints domains	PR00700	37	2	5227	13	PTPRC,PTPN6
3.681e-03	-5.60	KRAS (KRAS proto-oncogene, GTPase)	protein interactions	3845	2876	15	19454	49	RAPGEF6,MPP1,FCHO2,PPP1R7,ATP10D,PREX1,VMP1,OSBPL8,HCK,DOCK8,GAB1,RHBDF2,GRK6,PPFIBP2,SLC9A1
3.686e-03	-5.60	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	11	18204	48	SYK,PTPRC,PTPN6,OSBPL8,GRK6,HCK,BMP2K,ATG14,ACACB,MPP1,ENTPD1
3.714e-03	-5.60	positive regulation of calcium ion transport	biological process	GO:0051928	118	3	18204	48	CEMIP,SLC9A1,VMP1
3.714e-03	-5.60	regulation of receptor-mediated endocytosis	biological process	GO:0048259	118	3	18204	48	DAB2,BMP2K,SYK
3.742e-03	-5.59	nef (Nef)	protein interactions	156110	802	7	19454	49	SLC9A1,PTPRC,DOCK2,DAB2,SYK,TFEB,HCK
3.748e-03	-5.59	regulation of mononuclear cell proliferation	biological process	GO:0032944	242	4	18204	48	TMEM131L,PTPRC,PTPN6,VAV3
3.751e-03	-5.59	regulation of leukocyte activation	biological process	GO:0002694	572	6	18204	48	VAV3,PTPN6,SYK,TMEM131L,PTPRC,DOCK8
3.832e-03	-5.56	granulocyte activation	biological process	GO:0036230	35	2	18204	48	SYK,PREX1
3.847e-03	-5.56	CD79A (CD79a molecule)	protein interactions	973	255	4	19454	49	TMEM131L,PTPN6,SYK,PTPRC
3.864e-03	-5.56	FCERI mediated Ca+2 mobilization	REACTOME pathways	R-HSA-2871809	30	2	10285	32	VAV3,SYK
3.880e-03	-5.55	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	46	PREX1,HCK,DOCK2,FCHO2,SH2B3,STAB1,SMOX,PREX2
3.880e-03	-5.55	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	46	PREX1,HCK,FCHO2,DOCK2,SMOX,PREX2,SH2B3,STAB1
3.885e-03	-5.55	SH3 Domains	gene3d domains	2.30.30.40	223	4	14470	42	MPP1,DOCK2,HCK,VAV3
3.913e-03	-5.54	GPR183 (G protein-coupled receptor 183)	protein interactions	1880	37	2	19454	49	GRK6,OSBPL8
3.913e-03	-5.54	SNCG (synuclein gamma)	protein interactions	6623	37	2	19454	49	GRK6,SEMA4B
3.922e-03	-5.54	OPTN (optineurin)	protein interactions	10133	418	5	19454	49	MPP1,PPP1R7,OSBPL8,DOCK8,ATG14
4.051e-03	-5.51	regulation of homotypic cell-cell adhesion	biological process	GO:0034110	36	2	18204	48	SYK,SH2B3
4.111e-03	-5.49	BTK (Bruton tyrosine kinase)	protein interactions	695	128	3	19454	49	GAB1,HCK,SYK
4.111e-03	-5.49	GAB2 (GRB2 associated binding protein 2)	protein interactions	9846	128	3	19454	49	SYK,GAB1,PTPN6
4.121e-03	-5.49	PTPN6 (protein tyrosine phosphatase non-receptor type 6)	protein interactions	5777	260	4	19454	49	PTPRC,ASCC3,SYK,PTPN6
4.123e-03	-5.49	MPPED1 (metallophosphoesterase domain containing 1)	protein interactions	758	38	2	19454	49	PHKB,DISC1
4.123e-03	-5.49	FCGR3A (Fc gamma receptor IIIa)	protein interactions	2214	38	2	19454	49	SYK,PTPRC
4.123e-03	-5.49	STK33 (serine/threonine kinase 33)	protein interactions	65975	38	2	19454	49	HCK,PHKB
4.139e-03	-5.49	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	38	16828	46	ENTPD1,TMCC3,ACACB,SEMA4B,SH2B3,STAB1,SYK,GALNT1,RAPGEF6,GRK6,PPP1R7,RBM47,SLC9A1,OSBPL8,DOCK8,DOCK2,FCHO2,VAV3,PPFIBP2,PTGIR,BMP2K,RHBDF2,HCK,PREX1,ASCC3,PTPRC,DIAPH2,BLVRA,PREX2,KREMEN1,TFEB,DAB2,ATP10D,MPP1,CADM4,NACC2,GAB1,SLC16A10
4.148e-03	-5.49	phosphorus metabolic process	biological process	GO:0006793	1707	11	18204	48	OSBPL8,ATG14,PTPN6,SYK,PTPRC,BMP2K,ENTPD1,MPP1,ACACB,HCK,GRK6
4.148e-03	-5.49	regulation of calcium ion transport	biological process	GO:0051924	249	4	18204	48	SLC9A1,VMP1,CEMIP,PTPN6
4.157e-03	-5.48	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	21	16828	46	PTPN6,GAB1,RAPGEF6,MPP1,PPP1R7,GRK6,SH2B3,SEMA4B,DIAPH2,PREX2,DAB2,SYK,KREMEN1,TFEB,HCK,BMP2K,PREX1,PTPRC,VAV3,PPFIBP2,VMP1
4.159e-03	-5.48	SEMA	prosite domains	PS51004	31	2	12186	38	PLXND1,SEMA4B
4.160e-03	-5.48	thyroid	COSMIC cancer mutations	thyroid	9867	36	16828	46	ACACB,TMCC3,ATG14,PPP1R7,GRK6,RBM47,PLXND1,RAPGEF6,SYK,GALNT1,STAB1,SH2B3,SEMA4B,ASCC3,PREX1,RHBDF2,BMP2K,PTGIR,VAV3,PPFIBP2,DOCK2,DOCK8,VMP1,FCHO2,SMOX,TMTC1,GAB1,NACC2,ATP10D,ACER2,DAB2,KREMEN1,TFEB,BLVRA,DIAPH2,PREX2
4.231e-03	-5.47	cell development	biological process	GO:0048468	2236	13	18204	48	DIAPH2,PREX2,PTPN6,SYK,DISC1,PTPRC,SEMA4B,RBM47,DOCK2,RAPGEF6,PREX1,PLXND1,SH2B3
4.267e-03	-5.46	positive regulation of cell-substrate adhesion	biological process	GO:0010811	124	3	18204	48	DISC1,PREX1,DAB2
4.270e-03	-5.46	phagophore assembly site	cellular component	GO:0000407	38	2	19108	49	ATG14,VMP1
4.343e-03	-5.44	PDZ	pfam domains	PF00595	122	3	17795	48	MPP1,PREX2,RAPGEF6
4.364e-03	-5.43	regulation of cell-matrix adhesion	biological process	GO:0001952	125	3	18204	48	ACER2,SLC9A1,DISC1
4.386e-03	-5.43	ASIC4 (acid sensing ion channel subunit family member 4)	protein interactions	55515	131	3	19454	49	CADM4,TMEM131L,OSBPL8
4.452e-03	-5.41	pleura-mesothelioma	COSMIC cancer mutations	pleura-mesothelioma	4189	20	16828	46	DAB2,TFEB,KREMEN1,SYK,PREX2,DIAPH2,SEMA4B,GRK6,PPP1R7,RAPGEF6,PTPN6,GAB1,MPP1,PPFIBP2,VAV3,VMP1,PTPRC,PREX1,HCK,BMP2K
4.488e-03	-5.41	Signaling events mediated by Stem cell factor receptor (c-Kit)	Pathway Interaction DB	kitpathway	52	3	2226	15	PTPN6,GAB1,SH2B3
4.505e-03	-5.40	actin filament polymerization	biological process	GO:0030041	38	2	18204	48	PREX1,DIAPH2
4.513e-03	-5.40	positive regulation of T cell activation	biological process	GO:0050870	255	4	18204	48	PTPN6,PTPRC,SYK,DOCK8
4.544e-03	-5.39	GSK3B (glycogen synthase kinase 3 beta)	protein interactions	2932	831	7	19454	49	DAB2,ACACB,DISC1,MPP1,RAPGEF6,ASCC3,GAB1
4.545e-03	-5.39	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	43	16828	46	TMTC1,NACC2,PTPN6,GAB1,ATP10D,DISC1,DIAPH2,BLVRA,ASCC3,PTPRC,HCK,PPFIBP2,DOCK8,FCHO2,SMOX,OSBPL8,RBM47,PLXND1,PPP1R7,RAPGEF6,SYK,STAB1,ENTPD1,SLC16A10,CADM4,ACER2,MPP1,DAB2,KREMEN1,PREX2,PREX1,PTGIR,VAV3,DOCK2,VMP1,ATG14,SLC9A1,GRK6,GALNT1,SH2B3,SEMA4B,ACACB,TMCC3
4.561e-03	-5.39	PPFIA3 (PTPRF interacting protein alpha 3)	protein interactions	8541	40	2	19454	49	DISC1,PPFIBP2
4.574e-03	-5.39	RHOB (ras homolog family member B)	protein interactions	388	832	7	19454	49	FCHO2,SLC9A1,RAPGEF6,OSBPL8,GAB1,DIAPH2,DAB2
4.605e-03	-5.38	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	6	19454	49	PTPRC,DAB2,HCK,GAB1,PTPN6,SYK
4.627e-03	-5.38	SH3	smart domains	SM00326	202	4	9717	33	DOCK2,MPP1,HCK,VAV3
4.646e-03	-5.37	regulation of protein modification process	biological process	GO:0031399	1242	9	18204	48	CEMIP,ATG14,PPP1R7,PTPN6,PTPRC,SYK,CADM4,DAB2,ACER2
4.687e-03	-5.36	regulation of multicellular organismal development	biological process	GO:2000026	1484	10	18204	48	ACACB,PLXND1,STAB1,PTPN6,TMEM131L,SYK,GAB1,DISC1,PTPRC,BMP2K
4.695e-03	-5.36	leukocyte activation	biological process	GO:0045321	599	6	18204	48	PREX1,DOCK2,PTPN6,DOCK8,PTPRC,SYK
4.703e-03	-5.36	small GTPase-mediated signal transduction	biological process	GO:0007264	258	4	18204	48	DOCK8,DOCK2,RAPGEF6,VAV3
4.705e-03	-5.36	plasma membrane region	cellular component	GO:0098590	1278	9	19108	49	HCK,ENTPD1,RAPGEF6,SEMA4B,SLC9A1,FCHO2,PLXND1,SLC16A10,DOCK8
4.707e-03	-5.36	regulation of developmental process	biological process	GO:0050793	2540	14	18204	48	PTPN6,SYK,TMEM131L,PTPRC,DISC1,HCK,DAB2,KREMEN1,BMP2K,STAB1,GAB1,ACACB,PREX1,PLXND1
4.710e-03	-5.36	PTCH1 (patched 1)	protein interactions	5727	270	4	19454	49	SEMA4B,PLXND1,TMEM131L,CADM4
4.717e-03	-5.36	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	13	16828	46	PPFIBP2,VAV3,DOCK2,ASCC3,PREX2,DIAPH2,KREMEN1,GAB1,ATP10D,TMTC1,SLC16A10,PLXND1,GRK6
4.717e-03	-5.36	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	13	16828	46	KREMEN1,PREX2,DIAPH2,TMTC1,PLXND1,GRK6,SLC16A10,GAB1,ATP10D,PPFIBP2,VAV3,DOCK2,ASCC3
4.745e-03	-5.35	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	15	16828	46	DOCK2,SMOX,PREX1,ACACB,KREMEN1,TFEB,GALNT1,DIAPH2,PREX2,STAB1,SLC16A10,ATG14,ATP10D,GAB1,NACC2
4.758e-03	-5.35	small_intestine	COSMIC cancer mutations	small_intestine	250	4	16828	46	PLXND1,VMP1,PREX1,ASCC3
4.760e-03	-5.35	response to stimulus	biological process	GO:0050896	7803	30	18204	48	DOCK2,SEMA4B,SLC9A1,PREX2,PTPRC,SYK,DISC1,DOCK8,PTPN6,PTGIR,ASCC3,PLXND1,ACACB,ENTPD1,VAV3,KREMEN1,RAPGEF6,GRK6,HCK,DAB2,SMOX,TMEM131L,PREX1,ACER2,MPP1,SH2B3,GAB1,TFEB,STAB1,ATG14
4.770e-03	-5.35	Myo1c (myosin IC)	protein interactions	17913	135	3	19454	49	FCHO2,DAB2,BMP2K
4.777e-03	-5.34	ZFPL1 (zinc finger protein like 1)	protein interactions	7542	438	5	19454	49	FCHO2,DISC1,SLC9A1,OSBPL8,GAB1
4.823e-03	-5.33	ATG9A (autophagy related 9A)	protein interactions	79065	439	5	19454	49	BMP2K,FCHO2,DISC1,DAB2,PTGIR
4.871e-03	-5.32	SH3	prosite domains	PS50002	222	4	12186	38	VAV3,DOCK2,HCK,MPP1
4.873e-03	-5.32	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	7	16828	46	HCK,ATP10D,BMP2K,GRK6,PPFIBP2,DISC1,SYK
4.873e-03	-5.32	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	7	16828	46	ATP10D,BMP2K,HCK,GRK6,SYK,PPFIBP2,DISC1
4.890e-03	-5.32	Sema	smart domains	SM00630	31	2	9717	33	PLXND1,SEMA4B
4.897e-03	-5.32	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	21	16828	46	GRK6,PPP1R7,MPP1,RAPGEF6,PTPN6,GAB1,TFEB,KREMEN1,SYK,DAB2,PREX2,DIAPH2,SEMA4B,PTPRC,PREX1,BMP2K,HCK,VMP1,DOCK2,PPFIBP2,VAV3
4.897e-03	-5.32	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	21	16828	46	BMP2K,HCK,PREX1,PTPRC,DOCK2,VMP1,VAV3,PPFIBP2,MPP1,PTPN6,GAB1,RAPGEF6,GRK6,PPP1R7,SEMA4B,DIAPH2,PREX2,SYK,KREMEN1,TFEB,DAB2
5.031e-03	-5.29	Rrp1 (ribosomal RNA processing 1)	protein interactions	18114	2	1	19454	49	ASCC3
5.031e-03	-5.29	FABP6 (fatty acid binding protein 6)	protein interactions	2172	2	1	19454	49	OSBPL8
5.031e-03	-5.29	KIR2DL5A (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A)	protein interactions	57292	2	1	19454	49	PTPN6
5.031e-03	-5.29	Siglece (sialic acid binding Ig-like lectin E)	protein interactions	83382	2	1	19454	49	PTPN6
5.031e-03	-5.29	MPIG6B (megakaryocyte and platelet inhibitory receptor G6b)	protein interactions	80739	2	1	19454	49	PTPN6
5.031e-03	-5.29	GCNA (germ cell nuclear acidic peptidase)	protein interactions	93953	2	1	19454	49	CEMIP
5.031e-03	-5.29	CUZD1 (CUB and zona pellucida like domains 1)	protein interactions	50624	2	1	19454	49	PTPN6
5.081e-03	-5.28	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	13	16828	46	GAB1,ATP10D,TMTC1,GRK6,PLXND1,SLC16A10,PREX2,DIAPH2,KREMEN1,ASCC3,PPFIBP2,VAV3,DOCK2
5.122e-03	-5.27	extrinsic component of omegasome membrane	cellular component	GO:0097629	2	1	19108	49	ATG14
5.188e-03	-5.26	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	48	PTPN6,CEMIP,PTPRC
5.234e-03	-5.25	negative regulation of response to stimulus	biological process	GO:0048585	1760	11	18204	48	KREMEN1,SH2B3,CADM4,PTGIR,PTPN6,SYK,PTPRC,TMEM131L,RHBDF2,HCK,DAB2
5.236e-03	-5.25	regulation of inflammatory response	biological process	GO:0050727	428	5	18204	48	SYK,PTPRC,PTPN6,RHBDF2,HCK
5.254e-03	-5.25	ITGA1 (integrin subunit alpha 1)	protein interactions	3672	43	2	19454	49	DISC1,PTPN6
5.265e-03	-5.25	thyroid-other-neoplasm	COSMIC cancer mutations	thyroid-other-neoplasm	7637	30	16828	46	SMOX,FCHO2,DOCK2,DOCK8,PPFIBP2,PTGIR,BMP2K,RHBDF2,PREX1,PREX2,DIAPH2,BLVRA,TFEB,KREMEN1,DAB2,ACER2,ATP10D,NACC2,GAB1,TMTC1,TMCC3,ACACB,SEMA4B,STAB1,SH2B3,SYK,RAPGEF6,GRK6,PPP1R7,PLXND1
5.267e-03	-5.25	negative regulation of Kit signaling pathway	biological process	GO:1900235	2	1	18204	48	SH2B3
5.267e-03	-5.25	spermine catabolic process	biological process	GO:0046208	2	1	18204	48	SMOX
5.267e-03	-5.25	regulation of hematopoietic stem cell migration	biological process	GO:2000471	2	1	18204	48	PTPRC
5.267e-03	-5.25	serotonin secretion by platelet	biological process	GO:0002554	2	1	18204	48	SYK
5.267e-03	-5.25	positive regulation of protein tyrosine phosphatase activity	biological process	GO:1903615	2	1	18204	48	PTPRC
5.267e-03	-5.25	positive regulation of hematopoietic stem cell migration	biological process	GO:2000473	2	1	18204	48	PTPRC
5.267e-03	-5.25	malonyl-CoA biosynthetic process	biological process	GO:2001295	2	1	18204	48	ACACB
5.267e-03	-5.25	positive regulation of calcium:sodium antiporter activity	biological process	GO:1903281	2	1	18204	48	SLC9A1
5.267e-03	-5.25	regulation of interleukin-3 production	biological process	GO:0032672	2	1	18204	48	SYK
5.267e-03	-5.25	regulation of Kit signaling pathway	biological process	GO:1900234	2	1	18204	48	SH2B3
5.267e-03	-5.25	synaptic target recognition	biological process	GO:0008039	2	1	18204	48	PLXND1
5.267e-03	-5.25	thyroid-stimulating hormone secretion	biological process	GO:0070460	2	1	18204	48	SLC16A10
5.267e-03	-5.25	regulation of the force of heart contraction by cardiac conduction	biological process	GO:0086092	2	1	18204	48	SLC9A1
5.284e-03	-5.24	TMEM2_PANDER-like	interpro domains	IPR039473	2	1	18521	49	CEMIP
5.284e-03	-5.24	Liprin-beta_SAM_rpt_3	interpro domains	IPR037619	2	1	18521	49	PPFIBP2
5.284e-03	-5.24	TMEM131-like	interpro domains	IPR039877	2	1	18521	49	TMEM131L
5.284e-03	-5.24	Tyr_Pase_non-rcpt_typ-6/11	interpro domains	IPR012152	2	1	18521	49	PTPN6
5.284e-03	-5.24	iRhom1_2_N	interpro domains	IPR022241	2	1	18521	49	RHBDF2
5.284e-03	-5.24	ACCA_BT	interpro domains	IPR049074	2	1	18521	49	ACACB
5.284e-03	-5.24	ACCA	interpro domains	IPR049076	2	1	18521	49	ACACB
5.284e-03	-5.24	SYK/ZAP-70_N_SH2	interpro domains	IPR035838	2	1	18521	49	SYK
5.284e-03	-5.24	Dab_PTB	interpro domains	IPR048561	2	1	18521	49	DAB2
5.284e-03	-5.24	Kinase_SYK/ZAP-70_inter-SH2_sf	interpro domains	IPR023420	2	1	18521	49	SYK
5.284e-03	-5.24	DAB1/2_SBM	interpro domains	IPR048559	2	1	18521	49	DAB2
5.284e-03	-5.24	Liprin-beta_SAM_rpt_1	interpro domains	IPR037617	2	1	18521	49	PPFIBP2
5.284e-03	-5.24	UV_resistance/autophagy_Atg14	interpro domains	IPR018791	2	1	18521	49	ATG14
5.284e-03	-5.24	Tyr_kinase_non-rcpt_SYK/ZAP70	interpro domains	IPR012234	2	1	18521	49	SYK
5.284e-03	-5.24	Liprin-beta_SAM_rpt_2	interpro domains	IPR037618	2	1	18521	49	PPFIBP2
5.284e-03	-5.24	TMEM131-like_N	interpro domains	IPR022113	2	1	18521	49	TMEM131L
5.284e-03	-5.24	Kremen	interpro domains	IPR017076	2	1	18521	49	KREMEN1
5.284e-03	-5.24	AcCoA_COase_cen	interpro domains	IPR013537	2	1	18521	49	ACACB
5.284e-03	-5.24	TMEM131-like_conserved	interpro domains	IPR045695	2	1	18521	49	TMEM131L
5.299e-03	-5.24	vascular endothelial growth factor receptor 1 binding	molecular function	GO:0043183	2	1	18094	48	CADM4
5.299e-03	-5.24	biliverdin reductase (NADPH) activity	molecular function	GO:0106277	2	1	18094	48	BLVRA
5.299e-03	-5.24	acetyl-CoA carboxylase activity	molecular function	GO:0003989	2	1	18094	48	ACACB
5.299e-03	-5.24	L-phenylalanine transmembrane transporter activity	molecular function	GO:0015192	2	1	18094	48	SLC16A10
5.299e-03	-5.24	spermine:oxygen oxidoreductase (spermidine-forming) activity	molecular function	GO:0052901	2	1	18094	48	SMOX
5.299e-03	-5.24	biliverdin reductase (NAD(P)H) activity	molecular function	GO:0004074	2	1	18094	48	BLVRA
5.299e-03	-5.24	biliberdin reductase NAD+ activity	molecular function	GO:0106276	2	1	18094	48	BLVRA
5.299e-03	-5.24	phosphatidylserine transfer activity	molecular function	GO:0140343	2	1	18094	48	OSBPL8
5.377e-03	-5.23	regulation of leukocyte proliferation	biological process	GO:0070663	268	4	18204	48	PTPRC,TMEM131L,PTPN6,VAV3
5.382e-03	-5.22	lung-carcinoma	COSMIC cancer mutations	lung-carcinoma	4255	20	16828	46	PREX1,PTPRC,BMP2K,HCK,VMP1,VAV3,PPFIBP2,GRK6,PPP1R7,MPP1,PTPN6,GAB1,RAPGEF6,SYK,KREMEN1,TFEB,DAB2,SEMA4B,DIAPH2,PREX2
5.388e-03	-5.22	iRhom1-2_N	pfam domains	PF12595	2	1	17795	48	RHBDF2
5.388e-03	-5.22	ATG14	pfam domains	PF10186	2	1	17795	48	ATG14
5.388e-03	-5.22	TMEM131_like_N	pfam domains	PF12371	2	1	17795	48	TMEM131L
5.388e-03	-5.22	TMEM131_like	pfam domains	PF19532	2	1	17795	48	TMEM131L
5.388e-03	-5.22	ACC_central	pfam domains	PF08326	2	1	17795	48	ACACB
5.388e-03	-5.22	DAB2_SBM	pfam domains	PF21792	2	1	17795	48	DAB2
5.388e-03	-5.22	ACCA_BT	pfam domains	PF21385	2	1	17795	48	ACACB
5.481e-03	-5.21	positive regulation of interleukin-10 production	biological process	GO:0032733	42	2	18204	48	SYK,RBM47
5.495e-03	-5.20	positive regulation of cellular process	biological process	GO:0048522	5719	24	18204	48	HCK,DAB2,VMP1,PPP1R7,OSBPL8,ACER2,PREX1,BMP2K,ATG14,TFEB,GAB1,SEMA4B,RBM47,DOCK2,NACC2,SLC9A1,PTPN6,DOCK8,SYK,PTPRC,DISC1,PLXND1,VAV3,CEMIP
5.518e-03	-5.20	PSI	interpro domains	IPR016201	42	2	18521	49	SEMA4B,PLXND1
5.518e-03	-5.20	PTP_cat	interpro domains	IPR000242	42	2	18521	49	PTPN6,PTPRC
5.519e-03	-5.20	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051896	270	4	18204	48	SH2B3,PTPN6,OSBPL8,VAV3
5.545e-03	-5.19	SH2 domain binding	molecular function	GO:0042169	42	2	18094	48	SYK,PTPN6
5.545e-03	-5.19	intramembrane lipid transporter activity	molecular function	GO:0140303	42	2	18094	48	VMP1,ATP10D
5.603e-03	-5.18	FGFR4 (fibroblast growth factor receptor 4)	protein interactions	2264	455	5	19454	49	FCHO2,DAB2,MPP1,GAB1,PTPN6
5.632e-03	-5.18	myeloid leukocyte migration	biological process	GO:0097529	137	3	18204	48	SYK,PREX1,VAV3
5.632e-03	-5.18	cell recognition	biological process	GO:0008037	137	3	18204	48	DOCK2,DOCK8,PLXND1
5.654e-03	-5.18	GSK3A (glycogen synthase kinase 3 alpha)	protein interactions	2931	456	5	19454	49	GAB1,ASCC3,RAPGEF6,DAB2,ACACB
5.675e-03	-5.17	cellular process	biological process	GO:0009987	14996	46	18204	48	ACACB,ENTPD1,CADM4,KREMEN1,VAV3,RAPGEF6,SLC16A10,DOCK2,PREX2,PTPN6,DOCK8,DISC1,PTPRC,PREX1,SH2B3,MPP1,PHKB,BMP2K,GAB1,DAB2,GALNT1,RHBDF2,VMP1,OSBPL8,TMEM131L,PLXND1,ASCC3,PTGIR,CEMIP,SEMA4B,RBM47,NACC2,SLC9A1,PPFIBP2,SYK,ATP10D,ACER2,FCHO2,ATG14,TMTC1,STAB1,TFEB,HCK,GRK6,DIAPH2,SMOX
5.679e-03	-5.17	positive regulation of intracellular signal transduction	biological process	GO:1902533	1048	8	18204	48	NACC2,SLC9A1,VAV3,PTPRC,SYK,PTPN6,OSBPL8,DAB2
5.715e-03	-5.16	Fc Epsilon Receptor I Signaling in Mast Cells	SMPDB pathways	SMP0000358	34	2	1369	5	VAV3,SYK
5.727e-03	-5.16	Y_phosphatase	pfam domains	PF00102	42	2	17795	48	PTPN6,PTPRC
5.738e-03	-5.16	positive regulation of substrate adhesion-dependent cell spreading	biological process	GO:1900026	43	2	18204	48	DAB2,PREX1
5.738e-03	-5.16	semaphorin-plexin signaling pathway	biological process	GO:0071526	43	2	18204	48	PLXND1,SEMA4B
5.742e-03	-5.16	PILRB (paired immunoglobin like type 2 receptor beta)	protein interactions	29990	45	2	19454	49	GALNT1,PTPN6
5.742e-03	-5.16	SH3BP2 (SH3 domain binding protein 2)	protein interactions	6452	45	2	19454	49	VAV3,SYK
5.758e-03	-5.16	pleura	COSMIC cancer mutations	pleura	4914	22	16828	46	PTPRC,PREX1,HCK,BMP2K,PPFIBP2,VAV3,VMP1,SMOX,PPP1R7,GRK6,RAPGEF6,PTPN6,GAB1,MPP1,DAB2,TFEB,KREMEN1,SYK,SH2B3,PREX2,SEMA4B,DIAPH2
5.761e-03	-5.16	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	19	16828	46	DAB2,GALNT1,STAB1,PREX2,DIAPH2,OSBPL8,PLXND1,SLC9A1,RBM47,RAPGEF6,PTPN6,PPFIBP2,VAV3,DOCK2,DOCK8,SMOX,PREX1,ACACB,RHBDF2
5.777e-03	-5.15	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	19	16828	46	RAPGEF6,PTPN6,OSBPL8,SLC9A1,RBM47,PLXND1,STAB1,PREX2,DIAPH2,DAB2,GALNT1,RHBDF2,ACACB,PREX1,SMOX,PPFIBP2,VAV3,DOCK2,DOCK8
5.797e-03	-5.15	-	gene3d domains	6.10.250.1040	2	1	14470	42	SLC9A1
5.797e-03	-5.15	PreATP-grasp domain	gene3d domains	3.90.1770.10	2	1	14470	42	ACACB
5.797e-03	-5.15	Biotin dependent carboxylase carboxyltransferase	gene3d domains	2.40.460.10	2	1	14470	42	ACACB
5.797e-03	-5.15	-	gene3d domains	6.10.250.2260	2	1	14470	42	GRK6
5.859e-03	-5.14	GTPase activator activity	molecular function	GO:0005096	273	4	18094	48	PREX2,PREX1,DOCK2,VAV3
5.863e-03	-5.14	positive regulation of cation transmembrane transport	biological process	GO:1904064	139	3	18204	48	CEMIP,VMP1,SLC9A1
5.864e-03	-5.14	IGF1R (insulin like growth factor 1 receptor)	protein interactions	3480	460	5	19454	49	VAV3,FCHO2,GAB1,PTPN6,OSBPL8
5.887e-03	-5.14	TYR_PHOSPHATASE_PTP	prosite domains	PS50055	37	2	12186	38	PTPRC,PTPN6
5.993e-03	-5.12	positive regulation of cell communication	biological process	GO:0010647	1792	11	18204	48	DAB2,RBM47,SLC9A1,BMP2K,NACC2,VAV3,PTPRC,SYK,DISC1,OSBPL8,PTPN6
6.002e-03	-5.12	leukocyte degranulation	biological process	GO:0043299	44	2	18204	48	HCK,SYK
6.002e-03	-5.12	positive regulation of protein dephosphorylation	biological process	GO:0035307	44	2	18204	48	PPP1R7,PTPRC
6.002e-03	-5.12	response to electrical stimulus	biological process	GO:0051602	44	2	18204	48	SLC9A1,DISC1
6.002e-03	-5.12	regulation of peptidyl-threonine phosphorylation	biological process	GO:0010799	44	2	18204	48	CEMIP,CADM4
6.043e-03	-5.11	positive regulation of signaling	biological process	GO:0023056	1794	11	18204	48	OSBPL8,PTPN6,DISC1,PTPRC,SYK,VAV3,BMP2K,SLC9A1,NACC2,RBM47,DAB2
6.045e-03	-5.11	regulation of neuron projection development	biological process	GO:0010975	443	5	18204	48	KREMEN1,DAB2,PLXND1,PREX1,DISC1
6.083e-03	-5.10	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	42	16828	46	GAB1,PTPN6,CADM4,NACC2,MPP1,ACER2,ATP10D,TMTC1,SLC16A10,PREX2,BLVRA,DIAPH2,DAB2,TFEB,KREMEN1,HCK,RHBDF2,PTGIR,PTPRC,ASCC3,PREX1,SMOX,PPFIBP2,VAV3,FCHO2,VMP1,DOCK2,DOCK8,RAPGEF6,ATG14,OSBPL8,PPP1R7,SLC9A1,PLXND1,RBM47,STAB1,SH2B3,SEMA4B,GALNT1,SYK,ACACB,TMCC3
6.125e-03	-5.10	GOPC (golgi associated PDZ and coiled-coil motif containing)	protein interactions	57120	291	4	19454	49	RHBDF2,NACC2,HCK,GRK6
6.132e-03	-5.09	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	45	16828	46	ENTPD1,TMCC3,ACACB,GALNT1,SYK,SEMA4B,STAB1,SH2B3,SLC9A1,PPP1R7,RBM47,PLXND1,GRK6,ATG14,OSBPL8,RAPGEF6,VMP1,FCHO2,DOCK8,DOCK2,PPFIBP2,VAV3,SMOX,PTPRC,ASCC3,PREX1,PTGIR,BMP2K,HCK,RHBDF2,TFEB,KREMEN1,DAB2,PREX2,DIAPH2,BLVRA,SLC16A10,TMTC1,ACER2,MPP1,ATP10D,GAB1,NACC2,CADM4,PTPN6
6.189e-03	-5.08	positive regulation of leukocyte cell-cell adhesion	biological process	GO:1903039	279	4	18204	48	PTPN6,SYK,PTPRC,DOCK8
6.213e-03	-5.08	PAOs oxidise polyamines to amines	REACTOME pathways	R-HSA-141334	2	1	10285	32	SMOX
6.270e-03	-5.07	regulation of type I interferon-mediated signaling pathway	biological process	GO:0060338	45	2	18204	48	PTPN6,RBM47
6.270e-03	-5.07	positive regulation of B cell proliferation	biological process	GO:0030890	45	2	18204	48	PTPRC,VAV3
6.344e-03	-5.06	non-membrane spanning protein tyrosine kinase activity	molecular function	GO:0004715	45	2	18094	48	HCK,SYK
6.348e-03	-5.06	KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)	protein interactions	10008	294	4	19454	49	RHBDF2,TMEM131L,SLC9A1,GRK6
6.370e-03	-5.06	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	19	16828	46	SMOX,VAV3,PPFIBP2,DOCK8,DOCK2,ACACB,RHBDF2,PREX1,STAB1,DIAPH2,PREX2,DAB2,GALNT1,PTPN6,RAPGEF6,OSBPL8,SLC9A1,RBM47,PLXND1
6.441e-03	-5.05	membrane raft	cellular component	GO:0045121	290	4	19108	49	HCK,PTPRC,ENTPD1,SLC9A1
6.450e-03	-5.04	positive regulation of immune response	biological process	GO:0050778	640	6	18204	48	PTPRC,SYK,RBM47,PTPN6,VAV3,HCK
6.459e-03	-5.04	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	3	16828	46	DOCK2,ATP10D,NACC2
6.464e-03	-5.04	negative regulation of canonical Wnt signaling pathway	biological process	GO:0090090	144	3	18204	48	DAB2,KREMEN1,TMEM131L
6.468e-03	-5.04	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME pathways	R-HSA-983695	39	2	10285	32	SYK,PTPN6
6.505e-03	-5.04	SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like)	protein interactions	23384	151	3	19454	49	VMP1,DISC1,PPFIBP2
6.511e-03	-5.03	CNKSR1 (connector enhancer of kinase suppressor of Ras 1)	protein interactions	10256	48	2	19454	49	CADM4,PTPN6
6.532e-03	-5.03	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	26	16828	46	ATG14,OSBPL8,PLXND1,RAPGEF6,SYK,SH2B3,STAB1,SEMA4B,ACACB,TMTC1,MPP1,ATP10D,DISC1,DAB2,TFEB,KREMEN1,PREX2,DIAPH2,PTPRC,ASCC3,PREX1,VAV3,FCHO2,VMP1,DOCK2,SMOX
6.597e-03	-5.02	membrane microdomain	cellular component	GO:0098857	292	4	19108	49	PTPRC,HCK,SLC9A1,ENTPD1
6.652e-03	-5.01	mucin core 3 and core 4 O-glycosylation	BIOCYC pathways	META_PWY-7435	1	1	902	6	GALNT1
6.746e-03	-5.00	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	18	16828	46	GRK6,PPP1R7,RAPGEF6,PTPN6,GAB1,DAB2,TFEB,KREMEN1,SYK,PREX2,SEMA4B,PTPRC,PREX1,HCK,BMP2K,PPFIBP2,VAV3,VMP1
6.777e-03	-4.99	PTGFRN (prostaglandin F2 receptor inhibitor)	protein interactions	5738	49	2	19454	49	CEMIP,SLC9A1
6.782e-03	-4.99	localization	biological process	GO:0051179	4474	20	18204	48	DAB2,HCK,SLC16A10,DOCK2,RHBDF2,NACC2,SLC9A1,VMP1,ATP10D,SYK,DISC1,PTPRC,OSBPL8,ACACB,VAV3,TFEB,RAPGEF6,FCHO2,ATG14,STAB1
6.840e-03	-4.98	nodular	COSMIC cancer mutations	nodular	1515	10	16828	46	PREX2,STAB1,SYK,DOCK8,DOCK2,TFEB,DISC1,CADM4,RBM47,PTPRC
6.842e-03	-4.98	leukocyte chemotaxis	biological process	GO:0030595	147	3	18204	48	SYK,PREX1,VAV3
6.867e-03	-4.98	JAK2 (Janus kinase 2)	protein interactions	3717	154	3	19454	49	PTPN6,SH2B3,PTPRC
6.890e-03	-4.98	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	12	16828	46	ASCC3,PTGIR,DOCK8,VAV3,TMCC3,PPP1R7,GAB1,PTPN6,RAPGEF6,SYK,KREMEN1,TFEB
6.890e-03	-4.98	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	12	16828	46	GAB1,PTPN6,RAPGEF6,PTGIR,ASCC3,PPP1R7,TMCC3,VAV3,DOCK8,SYK,KREMEN1,TFEB
6.916e-03	-4.97	PTPc	smart domains	SM00194	37	2	9717	33	PTPRC,PTPN6
6.921e-03	-4.97	regulation of programmed cell death	biological process	GO:0043067	1569	10	18204	48	HCK,DAB2,ACER2,PLXND1,NACC2,SLC9A1,DOCK8,PTPRC,SYK,PTPN6
6.950e-03	-4.97	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	15	16828	46	ACACB,PREX1,SMOX,DOCK2,GAB1,NACC2,ATP10D,ATG14,SLC16A10,STAB1,DIAPH2,PREX2,KREMEN1,TFEB,GALNT1
6.969e-03	-4.97	TCTN2 (tectonic family member 2)	protein interactions	79867	302	4	19454	49	OSBPL8,TMEM131L,SLC9A1,VMP1
7.049e-03	-4.95	TRIM15 (tripartite motif containing 15)	protein interactions	89870	50	2	19454	49	GAB1,SYK
7.049e-03	-4.95	DOK1 (docking protein 1)	protein interactions	1796	50	2	19454	49	PTPN6,HCK
7.060e-03	-4.95	RHOG (ras homolog family member G)	protein interactions	391	902	7	19454	49	SLC9A1,FCHO2,VAV3,PREX2,GAB1,OSBPL8,DIAPH2
7.080e-03	-4.95	lymphocyte differentiation	biological process	GO:0030098	290	4	18204	48	SYK,PTPRC,DOCK2,PREX1
7.092e-03	-4.95	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	8	19454	49	TFEB,OSBPL8,GAB1,SH2B3,RAPGEF6,DISC1,TMCC3,PPFIBP2
7.098e-03	-4.95	T cell receptor signaling pathway	KEGG pathways	ko04660	102	3	7161	28	PTPN6,VAV3,PTPRC
7.098e-03	-4.95	T cell receptor signaling pathway	KEGG pathways	hsa04660	102	3	7161	28	VAV3,PTPRC,PTPN6
7.109e-03	-4.95	regulation of humoral immune response	biological process	GO:0002920	48	2	18204	48	PTPRC,PTPN6
7.130e-03	-4.94	RRP1B (ribosomal RNA processing 1B)	protein interactions	23076	304	4	19454	49	VMP1,PPP1R7,PTPN6,SYK
7.251e-03	-4.93	negative regulation of protein phosphorylation	biological process	GO:0001933	292	4	18204	48	ATG14,PTPN6,CADM4,PTPRC
7.325e-03	-4.92	SH2D2A (SH2 domain containing 2A)	protein interactions	9047	51	2	19454	49	GAB1,SYK
7.325e-03	-4.92	FCGR1A (Fc gamma receptor Ia)	protein interactions	2209	51	2	19454	49	HCK,SYK
7.325e-03	-4.92	IL4R (interleukin 4 receptor)	protein interactions	3566	51	2	19454	49	RHBDF2,PTPN6
7.390e-03	-4.91	regulation of immune system process	biological process	GO:0002682	1584	10	18204	48	RHBDF2,MPP1,RBM47,HCK,PTPN6,DOCK8,SYK,PTPRC,TMEM131L,VAV3
7.390e-03	-4.91	bone	COSMIC cancer mutations	bone	8157	31	16828	46	HCK,RHBDF2,PTPRC,PREX1,ASCC3,SMOX,PPFIBP2,VAV3,VMP1,DOCK8,DOCK2,NACC2,PTPN6,GAB1,MPP1,ATP10D,TMTC1,PREX2,DIAPH2,DAB2,KREMEN1,ACACB,TMCC3,ENTPD1,RAPGEF6,OSBPL8,GRK6,RBM47,PLXND1,STAB1,SEMA4B
7.399e-03	-4.91	platelet aggregation	biological process	GO:0070527	49	2	18204	48	PTPN6,ENTPD1
7.512e-03	-4.89	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	4	18204	48	DAB2,PTPN6,PTPRC,SYK
7.517e-03	-4.89	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	46	16828	46	BMP2K,PTGIR,RHBDF2,PREX1,DOCK2,VMP1,VAV3,ACER2,MPP1,CADM4,SLC16A10,PREX2,KREMEN1,TFEB,DAB2,ACACB,TMCC3,GRK6,SLC9A1,ATG14,SEMA4B,SH2B3,GALNT1,HCK,ASCC3,PTPRC,SMOX,DOCK8,FCHO2,PPFIBP2,ATP10D,PTPN6,GAB1,NACC2,TMTC1,DIAPH2,BLVRA,DISC1,ENTPD1,RAPGEF6,PLXND1,RBM47,PPP1R7,OSBPL8,STAB1,SYK
7.538e-03	-4.89	SIGLEC11 (sialic acid binding Ig like lectin 11)	protein interactions	114132	3	1	19454	49	PTPN6
7.538e-03	-4.89	Myo6 (myosin VI)	protein interactions	315840	3	1	19454	49	DAB2
7.538e-03	-4.89	Cbl (Casitas B-lineage lymphoma)	protein interactions	12402	3	1	19454	49	SYK
7.538e-03	-4.89	ACER1 (alkaline ceramidase 1)	protein interactions	125981	3	1	19454	49	MPP1
7.538e-03	-4.89	DYNLT2 (dynein light chain Tctex-type 2)	protein interactions	6991	3	1	19454	49	CEMIP
7.538e-03	-4.89	MAGEB3 (MAGE family member B3)	protein interactions	4114	3	1	19454	49	PPP1R7
7.538e-03	-4.89	HERC2P2 (HERC2 pseudogene 2)	protein interactions	400322	3	1	19454	49	DISC1
7.538e-03	-4.89	Srr (serine racemase)	protein interactions	27364	3	1	19454	49	DISC1
7.538e-03	-4.89	PAQR8 (progestin and adipoQ receptor family member 8)	protein interactions	85315	3	1	19454	49	MPP1
7.540e-03	-4.89	YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)	protein interactions	7531	1150	8	19454	49	SH2B3,GAB1,TFEB,OSBPL8,RAPGEF6,PPFIBP2,TMCC3,DISC1
7.605e-03	-4.88	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	49	HCK,SYK
7.626e-03	-4.88	PIGH (phosphatidylinositol glycan anchor biosynthesis class H)	protein interactions	5283	160	3	19454	49	OSBPL8,TMEM131L,RHBDF2
7.636e-03	-4.87	organophosphate ester transport	biological process	GO:0015748	153	3	18204	48	VMP1,OSBPL8,ATP10D
7.674e-03	-4.87	fatty acid beta-oxidation multienzyme complex	cellular component	GO:0036125	3	1	19108	49	ACACB
7.674e-03	-4.87	mitochondrial fatty acid beta-oxidation multienzyme complex	cellular component	GO:0016507	3	1	19108	49	ACACB
7.674e-03	-4.87	activating signal cointegrator 1 complex	cellular component	GO:0099053	3	1	19108	49	ASCC3
7.694e-03	-4.87	phospholipid translocation	biological process	GO:0045332	50	2	18204	48	VMP1,ATP10D
7.816e-03	-4.85	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	38	16828	46	FCHO2,DOCK8,DOCK2,PPFIBP2,VAV3,PTGIR,BMP2K,HCK,RHBDF2,PTPRC,PREX1,ASCC3,PREX2,BLVRA,DIAPH2,TFEB,KREMEN1,DAB2,MPP1,ATP10D,GAB1,NACC2,CADM4,SLC16A10,ENTPD1,TMCC3,ACACB,SEMA4B,STAB1,SH2B3,GALNT1,SYK,RAPGEF6,SLC9A1,PPP1R7,GRK6,RBM47,OSBPL8
7.828e-03	-4.85	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	7	16828	46	PREX2,DOCK8,DOCK2,VAV3,ATP10D,ASCC3,PTPRC
7.890e-03	-4.84	serotonin secretion	biological process	GO:0001820	3	1	18204	48	SYK
7.890e-03	-4.84	positive regulation of aldosterone biosynthetic process	biological process	GO:0032349	3	1	18204	48	DAB2
7.890e-03	-4.84	beta selection	biological process	GO:0043366	3	1	18204	48	SYK
7.890e-03	-4.84	leukocyte migration involved in immune response	biological process	GO:0002522	3	1	18204	48	HCK
7.890e-03	-4.84	positive regulation of mineralocorticoid secretion	biological process	GO:2000857	3	1	18204	48	DAB2
7.890e-03	-4.84	positive regulation of ATPase-coupled calcium transmembrane transporter activity	biological process	GO:1901896	3	1	18204	48	VMP1
7.890e-03	-4.84	positive regulation of clathrin-dependent endocytosis	biological process	GO:2000370	3	1	18204	48	DAB2
7.890e-03	-4.84	tyrosine transport	biological process	GO:0015828	3	1	18204	48	SLC16A10
7.890e-03	-4.84	positive regulation of aldosterone metabolic process	biological process	GO:0032346	3	1	18204	48	DAB2
7.890e-03	-4.84	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	48	SLC9A1
7.890e-03	-4.84	protein localization to nuclear pore	biological process	GO:0090204	3	1	18204	48	OSBPL8
7.890e-03	-4.84	pyramidal neuron migration to cerebral cortex	biological process	GO:0021852	3	1	18204	48	DISC1
7.890e-03	-4.84	serotonin secretion involved in inflammatory response	biological process	GO:0002442	3	1	18204	48	SYK
7.890e-03	-4.84	positive regulation of aldosterone secretion	biological process	GO:2000860	3	1	18204	48	DAB2
7.890e-03	-4.84	monocyte homeostasis	biological process	GO:0035702	3	1	18204	48	SH2B3
7.890e-03	-4.84	myeloid dendritic cell activation involved in immune response	biological process	GO:0002277	3	1	18204	48	DOCK2
7.890e-03	-4.84	serotonin production involved in inflammatory response	biological process	GO:0002351	3	1	18204	48	SYK
7.890e-03	-4.84	membrane raft polarization	biological process	GO:0001766	3	1	18204	48	DOCK2
7.891e-03	-4.84	FCGR2A (Fc gamma receptor IIa)	protein interactions	2212	53	2	19454	49	HCK,SYK
7.913e-03	-4.84	positive regulation of monoatomic ion transmembrane transport	biological process	GO:0034767	155	3	18204	48	VMP1,SLC9A1,CEMIP
7.913e-03	-4.84	myeloid leukocyte activation	biological process	GO:0002274	155	3	18204	48	PREX1,DOCK2,SYK
7.916e-03	-4.84	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	46	16828	46	ATG14,SLC9A1,GRK6,GALNT1,SH2B3,SEMA4B,ACACB,TMCC3,SLC16A10,CADM4,MPP1,ACER2,DAB2,TFEB,KREMEN1,PREX2,PREX1,RHBDF2,PTGIR,BMP2K,VAV3,VMP1,DOCK2,OSBPL8,PPP1R7,PLXND1,RBM47,RAPGEF6,SYK,STAB1,ENTPD1,TMTC1,GAB1,NACC2,PTPN6,ATP10D,DISC1,BLVRA,DIAPH2,PTPRC,ASCC3,HCK,PPFIBP2,FCHO2,DOCK8,SMOX
7.916e-03	-4.84	PHK_A/B_su	interpro domains	IPR008734	3	1	18521	49	PHKB
7.916e-03	-4.84	MiT/TFE_N	interpro domains	IPR031867	3	1	18521	49	TFEB
7.916e-03	-4.84	KPBA/B_C	interpro domains	IPR045583	3	1	18521	49	PHKB
7.916e-03	-4.84	PH_Vav	interpro domains	IPR037832	3	1	18521	49	VAV3
7.916e-03	-4.84	GH15-like	interpro domains	IPR011613	3	1	18521	49	PHKB
7.916e-03	-4.84	Phe_ZIP_sf	interpro domains	IPR036290	3	1	18521	49	SH2B3
7.916e-03	-4.84	SH2B	interpro domains	IPR030523	3	1	18521	49	SH2B3
7.916e-03	-4.84	NHE_CaM-bd	interpro domains	IPR032103	3	1	18521	49	SLC9A1
7.916e-03	-4.84	DIA_GBD_sf	interpro domains	IPR044933	3	1	18521	49	DIAPH2
7.916e-03	-4.84	C2_Dock-C	interpro domains	IPR037808	3	1	18521	49	DOCK8
7.916e-03	-4.84	Phe_ZIP	interpro domains	IPR015012	3	1	18521	49	SH2B3
7.916e-03	-4.84	Muniscin_C	interpro domains	IPR018808	3	1	18521	49	FCHO2
7.916e-03	-4.84	ACER	interpro domains	IPR008901	3	1	18521	49	ACER2
7.938e-03	-4.84	polyamine oxidase activity	molecular function	GO:0046592	3	1	18094	48	SMOX
7.938e-03	-4.84	L-tryptophan transmembrane transporter activity	molecular function	GO:0015196	3	1	18094	48	SLC16A10
7.938e-03	-4.84	apyrase activity	molecular function	GO:0004050	3	1	18094	48	ENTPD1
7.938e-03	-4.84	dihydroceramidase activity	molecular function	GO:0071633	3	1	18094	48	ACER2
7.938e-03	-4.84	glycosylceramide flippase activity	molecular function	GO:0140351	3	1	18094	48	ATP10D
7.942e-03	-4.84	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	25	16828	46	ACER2,NACC2,TMTC1,PREX2,DIAPH2,KREMEN1,DAB2,HCK,RHBDF2,PTPRC,ASCC3,PREX1,VMP1,DOCK8,DOCK2,PPFIBP2,RAPGEF6,SLC9A1,PLXND1,RBM47,OSBPL8,ATG14,STAB1,GALNT1,ACACB
7.980e-03	-4.83	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	25	16828	46	ACACB,GALNT1,STAB1,RBM47,SLC9A1,PLXND1,ATG14,OSBPL8,RAPGEF6,DOCK8,DOCK2,VMP1,PPFIBP2,PREX1,ASCC3,PTPRC,RHBDF2,HCK,KREMEN1,DAB2,DIAPH2,PREX2,TMTC1,ACER2,NACC2
8.071e-03	-4.82	MITF_TFEB_C_3_N	pfam domains	PF15951	3	1	17795	48	TFEB
8.071e-03	-4.82	muHD	pfam domains	PF10291	3	1	17795	48	FCHO2
8.071e-03	-4.82	KPBB_C	pfam domains	PF19292	3	1	17795	48	PHKB
8.071e-03	-4.82	Glyco_hydro_15	pfam domains	PF00723	3	1	17795	48	PHKB
8.071e-03	-4.82	NEXCaM_BD	pfam domains	PF16644	3	1	17795	48	SLC9A1
8.071e-03	-4.82	Phe_ZIP	pfam domains	PF08916	3	1	17795	48	SH2B3
8.071e-03	-4.82	Ceramidase	pfam domains	PF05875	3	1	17795	48	ACER2
8.159e-03	-4.81	HSPB8 (heat shock protein family B (small) member 8)	protein interactions	26353	164	3	19454	49	RHBDF2,ASCC3,NACC2
8.239e-03	-4.80	LGALS1 (galectin 1)	protein interactions	3956	317	4	19454	49	PLXND1,OSBPL8,HCK,PTPRC
8.296e-03	-4.79	C8orf33 (chromosome 8 open reading frame 33)	protein interactions	65265	165	3	19454	49	SYK,PTPN6,DISC1
8.296e-03	-4.79	NUBP2 (NUBP iron-sulfur cluster assembly factor 2, cytosolic)	protein interactions	10101	165	3	19454	49	GAB1,GALNT1,GRK6
8.326e-03	-4.79	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	19	16828	46	DOCK8,DOCK2,ACACB,PTPRC,PREX1,PREX2,BLVRA,DIAPH2,STAB1,TFEB,GALNT1,KREMEN1,DAB2,ACER2,ATP10D,GAB1,GRK6,OSBPL8,ATG14
8.468e-03	-4.77	autophagosome membrane	cellular component	GO:0000421	54	2	19108	49	VMP1,ATG14
8.483e-03	-4.77	phagocytosis	biological process	GO:0006909	159	3	18204	48	HCK,VAV3,SYK
8.612e-03	-4.75	regulation of platelet activation	biological process	GO:0010543	53	2	18204	48	SH2B3,SYK
8.612e-03	-4.75	positive regulation of calcium-mediated signaling	biological process	GO:0050850	53	2	18204	48	SLC9A1,SYK
8.683e-03	-4.75	-	gene3d domains	6.10.250.2020	3	1	14470	42	SLC9A1
8.683e-03	-4.75	-	gene3d domains	1.20.58.630	3	1	14470	42	DIAPH2
8.683e-03	-4.75	-	gene3d domains	6.10.30.30	3	1	14470	42	DIAPH2
8.683e-03	-4.75	-	gene3d domains	6.10.140.110	3	1	14470	42	SH2B3
8.683e-03	-4.75	Formin, diaphanous GTPase-binding domain	gene3d domains	1.10.20.40	3	1	14470	42	DIAPH2
8.688e-03	-4.75	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	7	16828	46	STAB1,PREX2,SYK,HCK,RHBDF2,BMP2K,GRK6
8.713e-03	-4.74	RALBP1 (ralA binding protein 1)	protein interactions	10928	168	3	19454	49	RBM47,BMP2K,HCK
8.742e-03	-4.74	LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)	protein interactions	55004	714	6	19454	49	DIAPH2,DAB2,FCHO2,BMP2K,GAB1,OSBPL8
8.776e-03	-4.74	regulation of transmembrane transport	biological process	GO:0034762	485	5	18204	48	VMP1,SLC9A1,PTPN6,CEMIP,OSBPL8
8.778e-03	-4.74	BCR signaling pathway	Pathway Interaction DB	bcr_5pathway	66	3	2226	15	PTPRC,SYK,PTPN6
8.812e-03	-4.73	regulation of monoatomic cation transmembrane transport	biological process	GO:1904062	309	4	18204	48	VMP1,SLC9A1,CEMIP,PTPN6
8.847e-03	-4.73	PSI	smart domains	SM00423	42	2	9717	33	PLXND1,SEMA4B
8.928e-03	-4.72	regulation of lipid storage	biological process	GO:0010883	54	2	18204	48	ACACB,OSBPL8
8.928e-03	-4.72	positive regulation of receptor-mediated endocytosis	biological process	GO:0048260	54	2	18204	48	DAB2,SYK
8.928e-03	-4.72	positive regulation of dephosphorylation	biological process	GO:0035306	54	2	18204	48	PPP1R7,PTPRC
9.076e-03	-4.70	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	4	16828	46	DIAPH2,OSBPL8,VMP1,DOCK2
9.108e-03	-4.70	BCAP31 (B cell receptor associated protein 31)	protein interactions	10134	512	5	19454	49	VMP1,SLC9A1,OSBPL8,TMEM131L,RHBDF2
9.177e-03	-4.69	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	18	16828	46	TMCC3,DOCK2,ASCC3,PREX2,DIAPH2,STAB1,SH2B3,GALNT1,SYK,DAB2,RAPGEF6,PTPN6,GAB1,PLXND1,SLC9A1,SLC16A10,ATG14,TMTC1
9.177e-03	-4.69	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	18	16828	46	DOCK2,TMCC3,ASCC3,DAB2,GALNT1,SYK,SH2B3,STAB1,PREX2,DIAPH2,ATG14,TMTC1,SLC16A10,PLXND1,SLC9A1,RAPGEF6,GAB1,PTPN6
9.209e-03	-4.69	negative regulation of phosphorylation	biological process	GO:0042326	313	4	18204	48	ATG14,PTPN6,CADM4,PTPRC
9.249e-03	-4.68	autophagosome maturation	biological process	GO:0097352	55	2	18204	48	VMP1,ATG14
9.249e-03	-4.68	lipid translocation	biological process	GO:0034204	55	2	18204	48	ATP10D,VMP1
9.300e-03	-4.68	phospholipid binding	molecular function	GO:0005543	489	5	18094	48	SLC9A1,FCHO2,PREX1,OSBPL8,RAPGEF6
9.306e-03	-4.68	Interconversion of polyamines	REACTOME pathways	R-HSA-351200	3	1	10285	32	SMOX
9.328e-03	-4.67	cytoplasmic vesicle	cellular component	GO:0031410	2521	13	19108	49	DIAPH2,PTPRC,DAB2,DOCK2,PTPN6,STAB1,DISC1,ATG14,FCHO2,RAPGEF6,SYK,CEMIP,HCK
9.340e-03	-4.67	human chrXq21.33	chromosome location	human chrXq21.33	5	1	26134	49	DIAPH2
9.340e-03	-4.67	human chr6q16.3	chromosome location	human chr6q16.3	5	1	26134	49	ASCC3
9.342e-03	-4.67	cell differentiation	biological process	GO:0030154	3645	17	18204	48	PLXND1,PREX1,SH2B3,RAPGEF6,DAB2,HCK,DOCK2,RBM47,SEMA4B,SLC9A1,DIAPH2,PREX2,PTPRC,DISC1,SYK,OSBPL8,PTPN6
9.390e-03	-4.67	LRCH1 (leucine rich repeats and calponin homology domain containing 1)	protein interactions	23143	58	2	19454	49	DOCK8,TMEM131L
9.390e-03	-4.67	Sec24c (SEC24 homolog C, COPII coat complex component)	protein interactions	218811	58	2	19454	49	DAB2,BMP2K
9.391e-03	-4.67	upper_leg	COSMIC cancer mutations	upper_leg	880	7	16828	46	ATP10D,PTPRC,ASCC3,PREX2,VAV3,DOCK2,DOCK8
9.419e-03	-4.66	cellular developmental process	biological process	GO:0048869	3648	17	18204	48	SEMA4B,RBM47,DOCK2,HCK,DAB2,PTPN6,OSBPL8,DISC1,SYK,PTPRC,DIAPH2,PREX2,SLC9A1,SH2B3,PLXND1,PREX1,RAPGEF6
9.437e-03	-4.66	CLTB (clathrin light chain B)	protein interactions	1212	173	3	19454	49	FCHO2,DAB2,BMP2K
9.512e-03	-4.66	intracellular vesicle	cellular component	GO:0097708	2527	13	19108	49	FCHO2,ATG14,DISC1,RAPGEF6,SYK,CEMIP,HCK,DIAPH2,DAB2,DOCK2,PTPRC,STAB1,PTPN6
9.576e-03	-4.65	negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002823	56	2	18204	48	PTPN6,PTPRC
9.576e-03	-4.65	leukocyte cell-cell adhesion	biological process	GO:0007159	56	2	18204	48	SYK,PTPRC
9.586e-03	-4.65	NME2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	4831	174	3	19454	49	PREX1,DOCK8,PPP1R7
9.608e-03	-4.65	GTPase binding	molecular function	GO:0051020	315	4	18094	48	DIAPH2,DOCK2,RAPGEF6,ATG14
9.633e-03	-4.64	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	6	18204	48	DAB2,PPP1R7,ATG14,CEMIP,PTPRC,SYK
9.633e-03	-4.64	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	6	18204	48	PTPRC,SYK,ATG14,PPP1R7,CEMIP,DAB2
9.635e-03	-4.64	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	38	16828	46	ENTPD1,TMCC3,ACACB,SEMA4B,SH2B3,STAB1,SYK,SLC9A1,GRK6,PLXND1,OSBPL8,ATG14,SMOX,DOCK8,DOCK2,VMP1,FCHO2,VAV3,PPFIBP2,BMP2K,RHBDF2,HCK,PREX1,ASCC3,PTPRC,BLVRA,DIAPH2,PREX2,KREMEN1,DAB2,ATP10D,ACER2,CADM4,GAB1,PTPN6,NACC2,SLC16A10,TMTC1
9.695e-03	-4.64	lipid transporter activity	molecular function	GO:0005319	166	3	18094	48	VMP1,OSBPL8,ATP10D
9.743e-03	-4.63	regulation of protein phosphorylation	biological process	GO:0001932	917	7	18204	48	DAB2,CADM4,ATG14,PTPN6,CEMIP,SYK,PTPRC
9.851e-03	-4.62	FBXO22 (F-box protein 22)	protein interactions	26263	522	5	19454	49	MPP1,DIAPH2,ACACB,OSBPL8,ASCC3
9.852e-03	-4.62	cellular component assembly	biological process	GO:0022607	2472	13	18204	48	FCHO2,RAPGEF6,ATG14,VAV3,ACACB,PLXND1,PREX1,DISC1,SLC9A1,NACC2,DIAPH2,VMP1,DAB2
9.853e-03	-4.62	CLTA (clathrin light chain A)	protein interactions	1211	334	4	19454	49	DOCK8,BMP2K,FCHO2,DAB2
9.871e-03	-4.62	cell-cell junction	cellular component	GO:0005911	513	5	19108	49	GAB1,CADM4,SLC9A1,PTPN6,MPP1
9.908e-03	-4.61	negative regulation of lymphocyte mediated immunity	biological process	GO:0002707	57	2	18204	48	PTPN6,PTPRC
9.960e-03	-4.61	regulation of phosphate metabolic process	biological process	GO:0019220	1154	8	18204	48	CADM4,DAB2,CEMIP,PPP1R7,PTPN6,ATG14,SYK,PTPRC
1.001e-02	-4.60	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	8	18204	48	CEMIP,PPP1R7,ATG14,PTPN6,PTPRC,SYK,CADM4,DAB2
1.002e-02	-4.60	CA2 (carbonic anhydrase 2)	protein interactions	760	60	2	19454	49	VAV3,SLC9A1
1.004e-02	-4.60	wound healing	biological process	GO:0042060	321	4	18204	48	VAV3,SYK,ENTPD1,PTPN6
1.004e-02	-4.60	Map6 (microtubule-associated protein 6)	protein interactions	29457	4	1	19454	49	PLXND1
1.004e-02	-4.60	H1-10-AS1 (H1-10 antisense RNA 1)	protein interactions	339942	4	1	19454	49	PTPN6
1.004e-02	-4.60	OTOP1 (otopetrin 1)	protein interactions	133060	4	1	19454	49	OSBPL8
1.004e-02	-4.60	MGAT3 (beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase)	protein interactions	4248	4	1	19454	49	DISC1
1.004e-02	-4.60	PVALB (parvalbumin)	protein interactions	5816	4	1	19454	49	ASCC3
1.004e-02	-4.60	Becn2 (beclin 2)	protein interactions	226720	4	1	19454	49	ATG14
1.004e-02	-4.60	PLEKHD1 (pleckstrin homology and coiled-coil domain containing D1)	protein interactions	400224	4	1	19454	49	SYK
1.004e-02	-4.60	ORF23 (ORF23)	protein interactions	4961503	4	1	19454	49	PPP1R7
1.004e-02	-4.60	FBXO41 (F-box protein 41)	protein interactions	150726	4	1	19454	49	DISC1
1.005e-02	-4.60	positive regulation of biological process	biological process	GO:0048518	6326	25	18204	48	DOCK8,DISC1,PTPRC,SYK,PTPN6,NACC2,SLC9A1,RBM47,DOCK2,SEMA4B,CEMIP,VAV3,PLXND1,ACACB,PPP1R7,OSBPL8,VMP1,HCK,DAB2,TFEB,GAB1,ATG14,BMP2K,ACER2,PREX1
1.014e-02	-4.59	cellular component organization	biological process	GO:0016043	5636	23	18204	48	DAB2,HCK,OSBPL8,VMP1,DIAPH2,PREX1,ATG14,FCHO2,TFEB,SEMA4B,DOCK2,ATP10D,PTPRC,DISC1,PREX2,PPFIBP2,SLC9A1,NACC2,ACACB,PLXND1,ASCC3,RAPGEF6,VAV3
1.019e-02	-4.59	DGCR2 (DiGeorge syndrome critical region gene 2)	protein interactions	9993	178	3	19454	49	OSBPL8,ASCC3,SLC9A1
1.022e-02	-4.58	omegasome membrane	cellular component	GO:1903349	4	1	19108	49	ATG14
1.022e-02	-4.58	central region of growth cone	cellular component	GO:0090724	4	1	19108	49	DISC1
1.037e-02	-4.57	C2 domain	gene3d domains	2.60.40.150	156	3	14470	42	DOCK2,ASCC3,DOCK8
1.044e-02	-4.56	endomembrane system	cellular component	GO:0012505	4764	20	19108	49	GALNT1,HCK,CEMIP,ACER2,DISC1,OSBPL8,ATG14,FCHO2,SMOX,PTPN6,TMCC3,TMTC1,ATP10D,RHBDF2,PTPRC,TMEM131L,DOCK2,DAB2,DIAPH2,VMP1
1.044e-02	-4.56	C2_domain_sf	interpro domains	IPR035892	171	3	18521	49	DOCK2,DOCK8,ASCC3
1.051e-02	-4.56	respiratory burst after phagocytosis	biological process	GO:0045728	4	1	18204	48	HCK
1.051e-02	-4.56	positive regulation of steroid hormone biosynthetic process	biological process	GO:0090031	4	1	18204	48	DAB2
1.051e-02	-4.56	negative regulation of cell adhesion involved in substrate-bound cell migration	biological process	GO:0006933	4	1	18204	48	PTPRC
1.051e-02	-4.56	DN2 thymocyte differentiation	biological process	GO:1904155	4	1	18204	48	PTPRC
1.051e-02	-4.56	phenylalanine transport	biological process	GO:0015823	4	1	18204	48	SLC16A10
1.051e-02	-4.56	negative regulation of mast cell activation involved in immune response	biological process	GO:0033007	4	1	18204	48	PTPN6
1.051e-02	-4.56	cellular response to molecule of fungal origin	biological process	GO:0071226	4	1	18204	48	SYK
1.051e-02	-4.56	polyamine catabolic process	biological process	GO:0006598	4	1	18204	48	SMOX
1.051e-02	-4.56	plasma membrane lactate transport	biological process	GO:0035879	4	1	18204	48	ACACB
1.051e-02	-4.56	regulation of protein tyrosine phosphatase activity	biological process	GO:1903613	4	1	18204	48	PTPRC
1.051e-02	-4.56	positive regulation of mast cell cytokine production	biological process	GO:0032765	4	1	18204	48	SYK
1.051e-02	-4.56	positive regulation of establishment of T cell polarity	biological process	GO:1903905	4	1	18204	48	DOCK8
1.051e-02	-4.56	dichotomous subdivision of terminal units involved in salivary gland branching	biological process	GO:0060666	4	1	18204	48	PLXND1
1.054e-02	-4.55	VTT_dom	interpro domains	IPR032816	4	1	18521	49	VMP1
1.054e-02	-4.55	COA_CT_N	interpro domains	IPR011762	4	1	18521	49	ACACB
1.054e-02	-4.55	FAS1_domain	interpro domains	IPR000782	4	1	18521	49	STAB1
1.054e-02	-4.55	AcCoA_carboxyl_beta	interpro domains	IPR034733	4	1	18521	49	ACACB
1.054e-02	-4.55	Sec63-dom	interpro domains	IPR004179	4	1	18521	49	ASCC3
1.054e-02	-4.55	FAS1_dom_sf	interpro domains	IPR036378	4	1	18521	49	STAB1
1.054e-02	-4.55	TEX28/TMCC	interpro domains	IPR019394	4	1	18521	49	TMCC3
1.054e-02	-4.55	Gfo/Idh/MocA-like_OxRdtase_N	interpro domains	IPR000683	4	1	18521	49	BLVRA
1.054e-02	-4.55	Gab1-4-like	interpro domains	IPR046355	4	1	18521	49	GAB1
1.054e-02	-4.55	MiT/TFE_C	interpro domains	IPR021802	4	1	18521	49	TFEB
1.054e-02	-4.55	G8_domain	interpro domains	IPR019316	4	1	18521	49	CEMIP
1.054e-02	-4.55	COA_CT_C	interpro domains	IPR011763	4	1	18521	49	ACACB
1.054e-02	-4.55	TMTC_DUF1736	interpro domains	IPR013618	4	1	18521	49	TMTC1
1.057e-02	-4.55	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor	molecular function	GO:0016647	4	1	18094	48	SMOX
1.057e-02	-4.55	stem cell factor receptor binding	molecular function	GO:0005173	4	1	18094	48	SH2B3
1.057e-02	-4.55	beta-adrenergic receptor kinase activity	molecular function	GO:0047696	4	1	18094	48	GRK6
1.057e-02	-4.55	CDP phosphatase activity	molecular function	GO:0036384	4	1	18094	48	ENTPD1
1.057e-02	-4.55	IDP phosphatase activity	molecular function	GO:1990003	4	1	18094	48	ENTPD1
1.067e-02	-4.54	PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2)	protein interactions	5504	62	2	19454	49	PPP1R7,BMP2K
1.074e-02	-4.53	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	28	16828	46	GALNT1,SYK,STAB1,GRK6,RBM47,PLXND1,SLC9A1,OSBPL8,RAPGEF6,ACACB,KREMEN1,DAB2,PREX2,SLC16A10,TMTC1,MPP1,ATP10D,NACC2,GAB1,VMP1,DOCK8,DOCK2,PPFIBP2,SMOX,PTPRC,PREX1,ASCC3,BMP2K
1.074e-02	-4.53	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	28	16828	46	ACACB,STAB1,SYK,GALNT1,RAPGEF6,OSBPL8,SLC9A1,PLXND1,GRK6,RBM47,SMOX,PPFIBP2,DOCK2,DOCK8,VMP1,BMP2K,ASCC3,PREX1,PTPRC,PREX2,DAB2,KREMEN1,NACC2,GAB1,ATP10D,MPP1,TMTC1,SLC16A10
1.075e-02	-4.53	Carboxyl_trans	pfam domains	PF01039	4	1	17795	48	ACACB
1.075e-02	-4.53	TMTC_DUF1736	pfam domains	PF08409	4	1	17795	48	TMTC1
1.075e-02	-4.53	SNARE_assoc	pfam domains	PF09335	4	1	17795	48	VMP1
1.075e-02	-4.53	DUF3371	pfam domains	PF11851	4	1	17795	48	TFEB
1.075e-02	-4.53	Fasciclin	pfam domains	PF02469	4	1	17795	48	STAB1
1.075e-02	-4.53	Tmemb_cc2	pfam domains	PF10267	4	1	17795	48	TMCC3
1.075e-02	-4.53	G8	pfam domains	PF10162	4	1	17795	48	CEMIP
1.075e-02	-4.53	GFO_IDH_MocA	pfam domains	PF01408	4	1	17795	48	BLVRA
1.075e-02	-4.53	Sec63	pfam domains	PF02889	4	1	17795	48	ASCC3
1.080e-02	-4.53	positive regulation of cell-cell adhesion	biological process	GO:0022409	328	4	18204	48	PTPN6,DOCK8,PTPRC,SYK
1.083e-02	-4.53	ASCC3 (activating signal cointegrator 1 complex subunit 3)	protein interactions	10973	182	3	19454	49	ASCC3,PTPN6,ENTPD1
1.087e-02	-4.52	lower_third	COSMIC cancer mutations	lower_third	7961	30	16828	46	SH2B3,STAB1,SEMA4B,SYK,GALNT1,RAPGEF6,OSBPL8,ATG14,SLC9A1,GRK6,PLXND1,ACACB,DIAPH2,PREX2,DAB2,DISC1,KREMEN1,TFEB,ATP10D,MPP1,TMTC1,SLC16A10,SMOX,VAV3,DOCK2,FCHO2,VMP1,PREX1,ASCC3,PTPRC
1.089e-02	-4.52	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	46	PREX2
1.089e-02	-4.52	idiopathic_erythrocytosis	COSMIC cancer mutations	idiopathic_erythrocytosis	4	1	16828	46	SH2B3
1.089e-02	-4.52	haematopoietic_and_lymphoid_tissue-other-idiopathic_erythrocytosis	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-other-idiopathic_erythrocytosis	4	1	16828	46	SH2B3
1.089e-02	-4.52	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	46	PREX2
1.091e-02	-4.52	ER-PR-positive_carcinoma	COSMIC cancer mutations	ER-PR-positive_carcinoma	1881	11	16828	46	RAPGEF6,PTPN6,GAB1,PPP1R7,TFEB,KREMEN1,SYK,ACACB,PTGIR,SMOX,VAV3
1.091e-02	-4.52	breast-carcinoma-ER-PR-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-ER-PR-positive_carcinoma	1881	11	16828	46	SMOX,VAV3,PTGIR,ACACB,TFEB,KREMEN1,SYK,RAPGEF6,PTPN6,GAB1,PPP1R7
1.091e-02	-4.52	regulation of leukocyte differentiation	biological process	GO:1902105	329	4	18204	48	PTPRC,SYK,TMEM131L,PTPN6
1.101e-02	-4.51	CD3E (CD3 epsilon subunit of T-cell receptor complex)	protein interactions	916	63	2	19454	49	SYK,TMEM131L
1.101e-02	-4.51	IFNAR1 (interferon alpha and beta receptor subunit 1)	protein interactions	3454	63	2	19454	49	PTPRC,PTPN6
1.101e-02	-4.51	PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)	protein interactions	55824	63	2	19454	49	PTPN6,SYK
1.104e-02	-4.51	specific granule lumen	cellular component	GO:0035580	62	2	19108	49	PTPN6,DOCK2
1.110e-02	-4.50	IL-6 signaling pathway	WikiPathways	WP364	43	2	5310	20	HCK,GAB1
1.115e-02	-4.50	CORO1B (coronin 1B)	protein interactions	57175	184	3	19454	49	RHBDF2,PHKB,VMP1
1.128e-02	-4.48	vacuolar localization	biological process	GO:1990849	61	2	18204	48	SYK,TFEB
1.128e-02	-4.48	lysosome localization	biological process	GO:0032418	61	2	18204	48	SYK,TFEB
1.128e-02	-4.48	negative regulation of adaptive immune response	biological process	GO:0002820	61	2	18204	48	PTPRC,PTPN6
1.131e-02	-4.48	SMAP2 (small ArfGAP2)	protein interactions	64744	185	3	19454	49	BMP2K,DAB2,RBM47
1.132e-02	-4.48	regulation of immune response	biological process	GO:0050776	944	7	18204	48	VAV3,PTPRC,SYK,PTPN6,HCK,RBM47,RHBDF2
1.133e-02	-4.48	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	28	16828	46	PTGIR,PTPRC,PREX1,ASCC3,VMP1,FCHO2,DOCK2,PPFIBP2,VAV3,MPP1,ATP10D,NACC2,CADM4,GAB1,SLC16A10,TMTC1,PREX2,BLVRA,DIAPH2,ACACB,TMCC3,PPP1R7,PLXND1,ATG14,OSBPL8,SEMA4B,SH2B3,STAB1
1.134e-02	-4.48	LRCH2 (leucine rich repeats and calponin homology domain containing 2)	protein interactions	57631	64	2	19454	49	DOCK2,DOCK8
1.134e-02	-4.48	TBXA2R (thromboxane A2 receptor)	protein interactions	6915	64	2	19454	49	PTGIR,GRK6
1.134e-02	-4.48	EVA1C (eva-1 homolog C)	protein interactions	59271	64	2	19454	49	ACACB,RHBDF2
1.135e-02	-4.48	negative regulation of Wnt signaling pathway	biological process	GO:0030178	177	3	18204	48	DAB2,KREMEN1,TMEM131L
1.136e-02	-4.48	Tyr_Pase_cat	interpro domains	IPR003595	61	2	18521	49	PTPN6,PTPRC
1.148e-02	-4.47	Actb (actin, beta)	protein interactions	11461	186	3	19454	49	DAB2,FCHO2,BMP2K
1.155e-02	-4.46	SHC1 (SHC adaptor protein 1)	protein interactions	6464	350	4	19454	49	VAV3,GAB1,PTPN6,SYK
1.156e-02	-4.46	FAS1 domain	gene3d domains	2.30.180.10	4	1	14470	42	STAB1
1.156e-02	-4.46	Sec63 N-terminal domain-like domain	gene3d domains	1.10.3380.10	4	1	14470	42	ASCC3
1.163e-02	-4.45	cell population proliferation	biological process	GO:0008283	726	6	18204	48	PTPN6,PTPRC,DISC1,DOCK8,DOCK2,ASCC3
1.163e-02	-4.45	EGF receptor (ErbB1) signaling pathway	Pathway Interaction DB	erbb1_receptor_proximal_pathway	25	2	2226	15	PTPN6,GAB1
1.164e-02	-4.45	regulation of immunoglobulin mediated immune response	biological process	GO:0002889	62	2	18204	48	PTPN6,PTPRC
1.164e-02	-4.45	regulation of membrane lipid distribution	biological process	GO:0097035	62	2	18204	48	ATP10D,VMP1
1.164e-02	-4.45	regulation of B cell mediated immunity	biological process	GO:0002712	62	2	18204	48	PTPN6,PTPRC
1.164e-02	-4.45	regulation of substrate adhesion-dependent cell spreading	biological process	GO:1900024	62	2	18204	48	PREX1,DAB2
1.168e-02	-4.45	RPS6KA6 (ribosomal protein S6 kinase A6)	protein interactions	27330	65	2	19454	49	MPP1,SLC9A1
1.168e-02	-4.45	LRRC55 (leucine rich repeat containing 55)	protein interactions	219527	65	2	19454	49	SLC9A1,SLC16A10
1.175e-02	-4.44	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	22	16828	46	ACACB,HCK,BMP2K,PREX1,PTPRC,VAV3,PPFIBP2,VMP1,PTPN6,GAB1,RAPGEF6,MPP1,PLXND1,GRK6,PPP1R7,SEMA4B,DIAPH2,PREX2,DAB2,KREMEN1,SYK,TFEB
1.175e-02	-4.44	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	22	16828	46	PLXND1,PPP1R7,GRK6,PTPN6,GAB1,RAPGEF6,MPP1,DAB2,KREMEN1,SYK,TFEB,DIAPH2,SEMA4B,PREX2,PREX1,PTPRC,ACACB,HCK,BMP2K,VAV3,PPFIBP2,VMP1
1.178e-02	-4.44	SH3_2	pfam domains	PF07653	61	2	17795	48	DOCK2,VAV3
1.188e-02	-4.43	phosphatidylinositol phosphate binding	molecular function	GO:1901981	179	3	18094	48	OSBPL8,FCHO2,SLC9A1
1.205e-02	-4.42	regulation of T cell proliferation	biological process	GO:0042129	181	3	18204	48	TMEM131L,PTPRC,PTPN6
1.208e-02	-4.42	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	48	DAB2,KREMEN1,DISC1,TMEM131L
1.210e-02	-4.41	small_intestine-carcinoid-endocrine_tumour	COSMIC cancer mutations	small_intestine-carcinoid-endocrine_tumour	175	3	16828	46	ASCC3,VMP1,PLXND1
1.217e-02	-4.41	response to chemical	biological process	GO:0042221	3743	17	18204	48	DAB2,HCK,SEMA4B,DOCK2,SMOX,SLC9A1,PTPN6,PTPRC,SYK,DOCK8,ACACB,PREX1,ACER2,PTGIR,SH2B3,VAV3,GAB1
1.230e-02	-4.40	Factors involved in megakaryocyte development and platelet production	REACTOME pathways	R-HSA-983231	156	3	10285	32	SH2B3,DOCK8,DOCK2
1.232e-02	-4.40	positive regulation of proteolysis	biological process	GO:0045862	341	4	18204	48	DAB2,ACER2,DISC1,SYK
1.235e-02	-4.39	TMT1A (thiol methyltransferase 1A)	protein interactions	25840	357	4	19454	49	OSBPL8,TMEM131L,VMP1,SLC9A1
1.237e-02	-4.39	regulation of B cell proliferation	biological process	GO:0030888	64	2	18204	48	PTPRC,VAV3
1.237e-02	-4.39	actin polymerization or depolymerization	biological process	GO:0008154	64	2	18204	48	PREX1,DIAPH2
1.238e-02	-4.39	ADXRDTASE	prints domains	PR00419	5	1	5227	13	SMOX
1.238e-02	-4.39	DUSP2 (dual specificity phosphatase 2)	protein interactions	1844	67	2	19454	49	ASCC3,TMEM131L
1.239e-02	-4.39	Scavenging by Class H Receptors	REACTOME pathways	R-HSA-3000497	4	1	10285	32	STAB1
1.239e-02	-4.39	ALKBH3 mediated reversal of alkylation damage	REACTOME pathways	R-HSA-112126	4	1	10285	32	ASCC3
1.239e-02	-4.39	Amine Oxidase reactions	REACTOME pathways	R-HSA-140179	4	1	10285	32	SMOX
1.242e-02	-4.39	G8	prosite domains	PS51484	4	1	12186	38	CEMIP
1.242e-02	-4.39	FAS1	prosite domains	PS50213	4	1	12186	38	STAB1
1.242e-02	-4.39	COA_CT_CTER	prosite domains	PS50989	4	1	12186	38	ACACB
1.242e-02	-4.39	COA_CT_NTER	prosite domains	PS50980	4	1	12186	38	ACACB
1.244e-02	-4.39	angiogenesis	biological process	GO:0001525	342	4	18204	48	VAV3,PLXND1,GAB1,SYK
1.246e-02	-4.39	EMD (emerin)	protein interactions	2010	771	6	19454	49	SLC9A1,TMCC3,VMP1,TMEM131L,OSBPL8,RHBDF2
1.246e-02	-4.39	KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1)	protein interactions	10657	358	4	19454	49	DISC1,DOCK2,PTPN6,HCK
1.251e-02	-4.38	phospholipid transporter activity	molecular function	GO:0005548	64	2	18094	48	VMP1,OSBPL8
1.253e-02	-4.38	FER1L4 (fer-1 like family member 4 (pseudogene))	protein interactions	80307	5	1	19454	49	CEMIP
1.253e-02	-4.38	ADCY10 (adenylate cyclase 10)	protein interactions	55811	5	1	19454	49	PTGIR
1.268e-02	-4.37	BRICD5 (BRICHOS domain containing 5)	protein interactions	283870	193	3	19454	49	SEMA4B,CADM4,TMEM131L
1.274e-02	-4.36	T cell differentiation in thymus	biological process	GO:0033077	65	2	18204	48	PTPRC,DOCK2
1.274e-02	-4.36	regulation of interleukin-10 production	biological process	GO:0032653	65	2	18204	48	SYK,RBM47
1.274e-02	-4.36	positive regulation of response to stimulus	biological process	GO:0048584	2266	12	18204	48	BMP2K,VAV3,HCK,DAB2,RBM47,SLC9A1,NACC2,DISC1,PTPRC,SYK,OSBPL8,PTPN6
1.275e-02	-4.36	lung-carcinoma-undifferentiated_carcinoma	COSMIC cancer mutations	lung-carcinoma-undifferentiated_carcinoma	1408	9	16828	46	PTGIR,RAPGEF6,GAB1,PTPN6,PPP1R7,TFEB,SYK,KREMEN1,VAV3
1.276e-02	-4.36	B cell receptor complex	cellular component	GO:0019815	5	1	19108	49	SYK
1.276e-02	-4.36	phosphorylase kinase complex	cellular component	GO:0005964	5	1	19108	49	PHKB
1.276e-02	-4.36	omegasome	cellular component	GO:1990462	5	1	19108	49	ATG14
1.276e-02	-4.36	apolipoprotein B mRNA editing enzyme complex	cellular component	GO:0030895	5	1	19108	49	RBM47
1.276e-02	-4.36	alpha-beta T cell receptor complex	cellular component	GO:0042105	5	1	19108	49	PTPN6
1.278e-02	-4.36	regulation of T cell differentiation	biological process	GO:0045580	185	3	18204	48	SYK,PTPRC,TMEM131L
1.278e-02	-4.36	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051897	185	3	18204	48	VAV3,OSBPL8,PTPN6
1.285e-02	-4.35	CNPY3 (canopy FGF signaling regulator 3)	protein interactions	10695	194	3	19454	49	VMP1,DIAPH2,HCK
1.298e-02	-4.34	RPN1 (ribophorin I)	protein interactions	6184	778	6	19454	49	OSBPL8,STAB1,TMEM131L,DOCK8,VMP1,SLC9A1
1.303e-02	-4.34	Myh9 (myosin, heavy polypeptide 9, non-muscle)	protein interactions	17886	195	3	19454	49	BMP2K,FCHO2,DAB2
1.305e-02	-4.34	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	49	PREX2
1.306e-02	-4.34	regulation of monoatomic ion transmembrane transport	biological process	GO:0034765	347	4	18204	48	VMP1,SLC9A1,CEMIP,PTPN6
1.310e-02	-4.34	ACAA1 (acetyl-CoA acyltransferase 1)	protein interactions	30	69	2	19454	49	ACACB,PPP1R7
1.310e-02	-4.34	PPP4R3B (protein phosphatase 4 regulatory subunit 3B)	protein interactions	57223	69	2	19454	49	SYK,OSBPL8
1.310e-02	-4.34	FAM8A1 (family with sequence similarity 8 member A1)	protein interactions	51439	69	2	19454	49	PTGIR,OSBPL8
1.310e-02	-4.34	PABPC3 (poly(A) binding protein cytoplasmic 3)	protein interactions	5042	69	2	19454	49	GAB1,CEMIP
1.312e-02	-4.33	negative regulation of immature T cell proliferation	biological process	GO:0033087	5	1	18204	48	TMEM131L
1.312e-02	-4.33	positive regulation of protein kinase C activity	biological process	GO:1900020	5	1	18204	48	CEMIP
1.312e-02	-4.33	spermine metabolic process	biological process	GO:0008215	5	1	18204	48	SMOX
1.312e-02	-4.33	epididymis development	biological process	GO:1905867	5	1	18204	48	PTPN6
1.312e-02	-4.33	thrombopoietin-mediated signaling pathway	biological process	GO:0038163	5	1	18204	48	SH2B3
1.312e-02	-4.33	regulation of mast cell activation involved in immune response	biological process	GO:0033006	5	1	18204	48	PTPN6
1.312e-02	-4.33	positive regulation of Fc receptor mediated stimulatory signaling pathway	biological process	GO:0060369	5	1	18204	48	PTPRC
1.312e-02	-4.33	positive regulation of the force of heart contraction	biological process	GO:0098735	5	1	18204	48	SLC9A1
1.312e-02	-4.33	response to molecule of fungal origin	biological process	GO:0002238	5	1	18204	48	SYK
1.312e-02	-4.33	negative regulation of immature T cell proliferation in thymus	biological process	GO:0033088	5	1	18204	48	TMEM131L
1.312e-02	-4.33	regulation of protein kinase C activity	biological process	GO:1900019	5	1	18204	48	CEMIP
1.312e-02	-4.33	myeloid cell activation involved in immune response	biological process	GO:0002275	66	2	18204	48	SYK,DOCK2
1.312e-02	-4.33	homotypic cell-cell adhesion	biological process	GO:0034109	66	2	18204	48	PTPN6,ENTPD1
1.316e-02	-4.33	HnRNP_R/Q_splicing_fac	interpro domains	IPR006535	5	1	18521	49	RBM47
1.316e-02	-4.33	WSC_carb-bd	interpro domains	IPR002889	5	1	18521	49	KREMEN1
1.316e-02	-4.33	Biotin_COase_C	interpro domains	IPR005482	5	1	18521	49	ACACB
1.316e-02	-4.33	DOCK_N	interpro domains	IPR032376	5	1	18521	49	DOCK2
1.316e-02	-4.33	BC-like_N	interpro domains	IPR005481	5	1	18521	49	ACACB
1.316e-02	-4.33	DOCK_N_sub1	interpro domains	IPR042455	5	1	18521	49	DOCK2
1.316e-02	-4.33	Biotin_carboxylation_dom	interpro domains	IPR011764	5	1	18521	49	ACACB
1.319e-02	-4.33	endoplasmic reticulum	cellular component	GO:0005783	2051	11	19108	49	VMP1,DIAPH2,ATG14,OSBPL8,TMEM131L,RHBDF2,ATP10D,TMCC3,TMTC1,CEMIP,GALNT1
1.320e-02	-4.33	ER retention sequence binding	molecular function	GO:0046923	5	1	18094	48	CEMIP
1.320e-02	-4.33	biotin binding	molecular function	GO:0009374	5	1	18094	48	ACACB
1.327e-02	-4.32	heme degradation	BIOCYC pathways	META_PWY-5874	2	1	902	6	BLVRA
1.327e-02	-4.32	spermine and spermidine degradation I	BIOCYC pathways	META_PWY-6117	2	1	902	6	SMOX
1.332e-02	-4.32	undifferentiated_carcinoma	COSMIC cancer mutations	undifferentiated_carcinoma	1418	9	16828	46	PTPN6,GAB1,RAPGEF6,PTGIR,PPP1R7,VAV3,KREMEN1,SYK,TFEB
1.339e-02	-4.31	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	3	19454	49	GAB1,HCK,DISC1
1.342e-02	-4.31	DOCK_N	pfam domains	PF16172	5	1	17795	48	DOCK2
1.342e-02	-4.31	Biotin_carb_N	pfam domains	PF00289	5	1	17795	48	ACACB
1.342e-02	-4.31	WSC	pfam domains	PF01822	5	1	17795	48	KREMEN1
1.342e-02	-4.31	Biotin_carb_C	pfam domains	PF02785	5	1	17795	48	ACACB
1.346e-02	-4.31	ITGB3 (integrin subunit beta 3)	protein interactions	3690	70	2	19454	49	SYK,DAB2
1.346e-02	-4.31	IL6ST (interleukin 6 cytokine family signal transducer)	protein interactions	3572	70	2	19454	49	HCK,PTPN6
1.352e-02	-4.30	Sec63	smart domains	SM00973	4	1	9717	33	ASCC3
1.352e-02	-4.30	FAS1	smart domains	SM00554	4	1	9717	33	STAB1
1.352e-02	-4.30	G8	smart domains	SM01225	4	1	9717	33	CEMIP
1.353e-02	-4.30	regulation of tumor necrosis factor production	biological process	GO:0032680	189	3	18204	48	PTPRC,SYK,PTPN6
1.354e-02	-4.30	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	49	GAB1,OSBPL8,FCHO2,RAPGEF6
1.355e-02	-4.30	phosphatase binding	molecular function	GO:0019902	188	3	18094	48	SLC9A1,SYK,CADM4
1.359e-02	-4.30	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	46	PREX2
1.363e-02	-4.30	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	3	16828	46	TMCC3,PREX1,OSBPL8
1.370e-02	-4.29	regulation of cellular component size	biological process	GO:0032535	352	4	18204	48	DISC1,VAV3,PREX1,HCK
1.383e-02	-4.28	CX3CL1 (C-X3-C motif chemokine ligand 1)	protein interactions	6376	71	2	19454	49	RHBDF2,SLC9A1
1.384e-02	-4.28	ORF3a (ORF3a protein)	protein interactions	43740569	789	6	19454	49	PLXND1,RHBDF2,OSBPL8,SEMA4B,BLVRA,GRK6
1.388e-02	-4.28	regulation of antigen receptor-mediated signaling pathway	biological process	GO:0050854	68	2	18204	48	PTPN6,PTPRC
1.388e-02	-4.28	negative regulation of leukocyte mediated immunity	biological process	GO:0002704	68	2	18204	48	PTPRC,PTPN6
1.388e-02	-4.28	cell-cell recognition	biological process	GO:0009988	68	2	18204	48	DOCK8,DOCK2
1.389e-02	-4.28	CDC42 (cell division cycle 42)	protein interactions	998	1280	8	19454	49	DIAPH2,DOCK8,OSBPL8,PREX2,GRK6,SLC9A1,FCHO2,PREX1
1.391e-02	-4.27	negative regulation of leukocyte activation	biological process	GO:0002695	191	3	18204	48	PTPN6,TMEM131L,PTPRC
1.392e-02	-4.27	DBN1 (drebrin 1)	protein interactions	1627	370	4	19454	49	BMP2K,DISC1,FCHO2,DAB2
1.413e-02	-4.26	positive regulation of immune system process	biological process	GO:0002684	986	7	18204	48	RBM47,HCK,PTPN6,DOCK8,SYK,PTPRC,VAV3
1.417e-02	-4.26	NHLRC2 (NHL repeat containing 2)	protein interactions	374354	372	4	19454	49	MPP1,BLVRA,TFEB,SYK
1.420e-02	-4.25	FANCL (FA complementation group L)	protein interactions	55120	72	2	19454	49	DOCK8,PPP1R7
1.420e-02	-4.25	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	49	DAB2,BMP2K
1.427e-02	-4.25	regulation of cardiac muscle hypertrophy	biological process	GO:0010611	69	2	18204	48	ACACB,SLC9A1
1.430e-02	-4.25	MYO6 (myosin VI)	protein interactions	4646	373	4	19454	49	DOCK8,DAB2,FCHO2,BMP2K
1.430e-02	-4.25	vacuole organization	biological process	GO:0007033	193	3	18204	48	VMP1,ATG14,TFEB
1.433e-02	-4.25	Natural killer cell mediated cytotoxicity	KEGG pathways	ko04650	132	3	7161	28	SYK,PTPN6,VAV3
1.433e-02	-4.25	Natural killer cell mediated cytotoxicity	KEGG pathways	hsa04650	132	3	7161	28	VAV3,PTPN6,SYK
1.443e-02	-4.24	localization within membrane	biological process	GO:0051668	549	5	18204	48	PTPRC,DOCK2,RHBDF2,RAPGEF6,FCHO2
1.443e-02	-4.24	-	gene3d domains	1.10.287.2720	5	1	14470	42	OSBPL8
1.443e-02	-4.24	Formin, FH3 diaphanous domain	gene3d domains	1.10.238.150	5	1	14470	42	DIAPH2
1.443e-02	-4.24	Dedicator of cytokinesis N-terminal subdomain	gene3d domains	1.20.1270.350	5	1	14470	42	DOCK2
1.448e-02	-4.23	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	46	16828	46	ENTPD1,SYK,STAB1,OSBPL8,PPP1R7,RBM47,PLXND1,RAPGEF6,PPFIBP2,FCHO2,DOCK8,SMOX,PTPRC,ASCC3,HCK,DISC1,BLVRA,DIAPH2,TMTC1,NACC2,PTPN6,GAB1,ATP10D,TMCC3,ACACB,GALNT1,SH2B3,SEMA4B,ATG14,GRK6,SLC9A1,VAV3,VMP1,DOCK2,PREX1,RHBDF2,BMP2K,PTGIR,DAB2,TFEB,KREMEN1,PREX2,SLC16A10,CADM4,MPP1,ACER2
1.449e-02	-4.23	positive regulation of protein modification process	biological process	GO:0031401	762	6	18204	48	CEMIP,PPP1R7,ATG14,PTPRC,SYK,DAB2
1.458e-02	-4.23	STAMBPL1 (STAM binding protein like 1)	protein interactions	57559	73	2	19454	49	RBM47,BMP2K
1.458e-02	-4.23	THBS3 (thrombospondin 3)	protein interactions	7059	73	2	19454	49	BLVRA,ASCC3
1.458e-02	-4.23	FCHO1 (FCH and mu domain containing endocytic adaptor 1)	protein interactions	23149	73	2	19454	49	FCHO2,DAB2
1.470e-02	-4.22	regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903555	195	3	18204	48	PTPN6,SYK,PTPRC
1.472e-02	-4.22	regulation of phosphorylation	biological process	GO:0042325	994	7	18204	48	CADM4,DAB2,CEMIP,ATG14,PTPN6,PTPRC,SYK
1.483e-02	-4.21	femur	COSMIC cancer mutations	femur	1197	8	16828	46	DAB2,TMCC3,STAB1,RBM47,OSBPL8,PTPRC,PREX1,RHBDF2
1.484e-02	-4.21	NRAGE signals death through JNK	REACTOME pathways	R-HSA-193648	60	2	10285	32	VAV3,PREX1
1.489e-02	-4.21	TNFRSF1A (TNF receptor superfamily member 1A)	protein interactions	7132	205	3	19454	49	GRK6,PTPN6,SYK
1.496e-02	-4.20	C2CD6 (C2 calcium dependent domain containing 6)	protein interactions	151254	74	2	19454	49	DISC1,ACACB
1.500e-02	-4.20	LAMP2 (lysosomal associated membrane protein 2)	protein interactions	3920	580	5	19454	49	ATG14,OSBPL8,FCHO2,VMP1,MPP1
1.502e-02	-4.20	echA1 (enoyl-CoA hydratase EchA1)	protein interactions	886723	6	1	19454	49	PTPN6
1.502e-02	-4.20	RXFP2 (relaxin family peptide receptor 2)	protein interactions	122042	6	1	19454	49	OSBPL8
1.502e-02	-4.20	ASIC5 (acid sensing ion channel subunit family member 5)	protein interactions	51802	6	1	19454	49	BLVRA
1.502e-02	-4.20	CCDC181 (coiled-coil domain containing 181)	protein interactions	57821	6	1	19454	49	PPP1R7
1.502e-02	-4.20	CD300LF (CD300 molecule like family member f)	protein interactions	146722	6	1	19454	49	PTPN6
1.502e-02	-4.20	CROCC2 (ciliary rootlet coiled-coil, rootletin family member 2)	protein interactions	728763	6	1	19454	49	CEMIP
1.511e-02	-4.19	protein localization to plasma membrane	biological process	GO:0072659	197	3	18204	48	FCHO2,RAPGEF6,RHBDF2
1.521e-02	-4.19	lamellipodium	cellular component	GO:0030027	203	3	19108	49	DOCK8,SLC9A1,PLXND1
1.521e-02	-4.19	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	49	ASCC3,CEMIP,SEMA4B,RBM47
1.524e-02	-4.18	phosphatidylserine binding	molecular function	GO:0001786	71	2	18094	48	FCHO2,OSBPL8
1.528e-02	-4.18	GTSE1 (G2 and S-phase expressed 1)	protein interactions	51512	207	3	19454	49	BMP2K,DAB2,FCHO2
1.529e-02	-4.18	mRNA editing complex	cellular component	GO:0045293	6	1	19108	49	RBM47
1.531e-02	-4.18	Regulation of actin dynamics for phagocytic cup formation	REACTOME pathways	R-HSA-2029482	61	2	10285	32	VAV3,SYK
1.532e-02	-4.18	mononuclear cell differentiation	biological process	GO:1903131	364	4	18204	48	PREX1,SYK,PTPRC,DOCK2
1.541e-02	-4.17	positive regulation of protein metabolic process	biological process	GO:0051247	1247	8	18204	48	PTPRC,DISC1,SYK,CEMIP,PPP1R7,ATG14,DAB2,ACER2
1.546e-02	-4.17	Hyaluronan biosynthesis and export	REACTOME pathways	R-HSA-2142850	5	1	10285	32	CEMIP
1.546e-02	-4.17	MET activates PTPN11	REACTOME pathways	R-HSA-8865999	5	1	10285	32	GAB1
1.547e-02	-4.17	cell-cell contact zone	cellular component	GO:0044291	74	2	19108	49	CADM4,SLC9A1
1.548e-02	-4.17	regulation of muscle hypertrophy	biological process	GO:0014743	72	2	18204	48	SLC9A1,ACACB
1.548e-02	-4.17	negative regulation of protein binding	biological process	GO:0032091	72	2	18204	48	DISC1,DAB2
1.548e-02	-4.17	HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11)	protein interactions	51170	382	4	19454	49	OSBPL8,TMEM131L,VMP1,SLC9A1
1.550e-02	-4.17	CPSASE_1	prosite domains	PS00866	5	1	12186	38	ACACB
1.550e-02	-4.17	WSC	prosite domains	PS51212	5	1	12186	38	KREMEN1
1.550e-02	-4.17	BC	prosite domains	PS50979	5	1	12186	38	ACACB
1.552e-02	-4.17	ameboidal-type cell migration	biological process	GO:0001667	199	3	18204	48	GAB1,SEMA4B,PLXND1
1.567e-02	-4.16	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	8	16828	46	ACACB,RHBDF2,HCK,DIAPH2,ENTPD1,SEMA4B,DOCK2,SYK
1.572e-02	-4.15	negative regulation of fatty acid beta-oxidation	biological process	GO:0031999	6	1	18204	48	ACACB
1.572e-02	-4.15	malonyl-CoA metabolic process	biological process	GO:2001293	6	1	18204	48	ACACB
1.572e-02	-4.15	regulation of establishment of T cell polarity	biological process	GO:1903903	6	1	18204	48	DOCK8
1.572e-02	-4.15	regulation of mast cell cytokine production	biological process	GO:0032763	6	1	18204	48	SYK
1.572e-02	-4.15	tryptophan transport	biological process	GO:0015827	6	1	18204	48	SLC16A10
1.572e-02	-4.15	regulation of mineralocorticoid secretion	biological process	GO:2000855	6	1	18204	48	DAB2
1.572e-02	-4.15	negative regulation of sequestering of triglyceride	biological process	GO:0010891	6	1	18204	48	OSBPL8
1.572e-02	-4.15	radial glia-guided pyramidal neuron migration	biological process	GO:0140650	6	1	18204	48	DISC1
1.572e-02	-4.15	regulation of aldosterone secretion	biological process	GO:2000858	6	1	18204	48	DAB2
1.572e-02	-4.15	intracellular glutamate homeostasis	biological process	GO:0090461	6	1	18204	48	ACACB
1.573e-02	-4.15	CST9L (cystatin 9 like)	protein interactions	128821	76	2	19454	49	GALNT1,SEMA4B
1.573e-02	-4.15	PGM3 (phosphoglucomutase 3)	protein interactions	5238	76	2	19454	49	DISC1,BLVRA
1.577e-02	-4.15	DOCK_C/D_N	interpro domains	IPR021816	6	1	18521	49	DOCK8
1.577e-02	-4.15	CAMSAP-like_CH_dom	interpro domains	IPR022613	6	1	18521	49	VAV3
1.577e-02	-4.15	Rudment_hybrid_motif	interpro domains	IPR011054	6	1	18521	49	ACACB
1.577e-02	-4.15	WxxW_domain	interpro domains	IPR025155	6	1	18521	49	CEMIP
1.577e-02	-4.15	Liprin	interpro domains	IPR029515	6	1	18521	49	PPFIBP2
1.581e-02	-4.15	phosphatidylinositol 3-kinase inhibitor activity	molecular function	GO:0141039	6	1	18094	48	ATG14
1.581e-02	-4.15	ceramidase activity	molecular function	GO:0102121	6	1	18094	48	ACER2
1.581e-02	-4.15	ADP phosphatase activity	molecular function	GO:0043262	6	1	18094	48	ENTPD1
1.581e-02	-4.15	CoA carboxylase activity	molecular function	GO:0016421	6	1	18094	48	ACACB
1.581e-02	-4.15	CTPase activity	molecular function	GO:0043273	6	1	18094	48	ENTPD1
1.581e-02	-4.15	protein phosphatase 2B binding	molecular function	GO:0030346	6	1	18094	48	SLC9A1
1.585e-02	-4.14	kidney	COSMIC cancer mutations	kidney	15380	46	16828	46	DAB2,TFEB,KREMEN1,PREX2,SLC16A10,CADM4,MPP1,ACER2,VAV3,VMP1,DOCK2,PREX1,RHBDF2,BMP2K,PTGIR,GALNT1,SH2B3,SEMA4B,ATG14,GRK6,SLC9A1,TMCC3,ACACB,DISC1,BLVRA,DIAPH2,TMTC1,GAB1,NACC2,PTPN6,ATP10D,PPFIBP2,FCHO2,DOCK8,SMOX,PTPRC,ASCC3,HCK,SYK,STAB1,OSBPL8,PLXND1,RBM47,PPP1R7,RAPGEF6,ENTPD1
1.588e-02	-4.14	positive regulation of alpha-beta T cell activation	biological process	GO:0046635	73	2	18204	48	PTPRC,SYK
1.588e-02	-4.14	endothelial cell migration	biological process	GO:0043542	73	2	18204	48	GAB1,PLXND1
1.588e-02	-4.14	positive regulation of phagocytosis	biological process	GO:0050766	73	2	18204	48	PTPRC,DOCK2
1.607e-02	-4.13	cargo receptor activity	molecular function	GO:0038024	73	2	18094	48	DAB2,STAB1
1.608e-02	-4.13	DOCK_C-D_N	pfam domains	PF11878	6	1	17795	48	DOCK8
1.608e-02	-4.13	CAMSAP_CH	pfam domains	PF11971	6	1	17795	48	VAV3
1.608e-02	-4.13	Mucin2_WxxW	pfam domains	PF13330	6	1	17795	48	CEMIP
1.613e-02	-4.13	SNX18 (sorting nexin 18)	protein interactions	112574	77	2	19454	49	ATG14,DISC1
1.617e-02	-4.12	Endoderm Differentiation	WikiPathways	WP2853	145	3	5310	20	DAB2,ASCC3,VAV3
1.619e-02	-4.12	humerus	COSMIC cancer mutations	humerus	546	5	16828	46	VMP1,DOCK2,OSBPL8,PPFIBP2,DIAPH2
1.623e-02	-4.12	cellular component organization or biogenesis	biological process	GO:0071840	5850	23	18204	48	DIAPH2,VMP1,OSBPL8,HCK,DAB2,ATG14,FCHO2,TFEB,PREX1,PREX2,NACC2,PPFIBP2,SLC9A1,DISC1,PTPRC,ATP10D,SEMA4B,DOCK2,VAV3,RAPGEF6,PLXND1,ACACB,ASCC3
1.627e-02	-4.12	SEC23B (SEC23 homolog B, COPII coat complex component)	protein interactions	10483	212	3	19454	49	GALNT1,DAB2,SYK
1.629e-02	-4.12	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	46	PREX2
1.629e-02	-4.12	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	46	PREX2
1.630e-02	-4.12	organelle localization by membrane tethering	biological process	GO:0140056	74	2	18204	48	ATG14,VMP1
1.630e-02	-4.12	negative regulation of T cell proliferation	biological process	GO:0042130	74	2	18204	48	PTPN6,TMEM131L
1.636e-02	-4.11	negative regulation of cell-cell adhesion	biological process	GO:0022408	203	3	18204	48	TMEM131L,PTPN6,SH2B3
1.639e-02	-4.11	regulation of apoptotic process	biological process	GO:0042981	1518	9	18204	48	PLXND1,DAB2,ACER2,HCK,PTPN6,PTPRC,DOCK8,SLC9A1,NACC2
1.641e-02	-4.11	Tyr_Pase_AS	interpro domains	IPR016130	74	2	18521	49	PTPN6,PTPRC
1.645e-02	-4.11	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	25	16828	46	ATP10D,ACER2,MPP1,SLC16A10,TMTC1,PREX2,DAB2,BMP2K,HCK,PREX1,ASCC3,PTPRC,DOCK2,DOCK8,FCHO2,PPFIBP2,SLC9A1,RBM47,GRK6,PLXND1,SH2B3,STAB1,SYK,ACACB,TMCC3
1.645e-02	-4.11	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	25	16828	46	ACACB,TMCC3,GRK6,PLXND1,RBM47,SLC9A1,SYK,SH2B3,STAB1,PTPRC,ASCC3,PREX1,BMP2K,HCK,FCHO2,DOCK8,DOCK2,PPFIBP2,SLC16A10,TMTC1,MPP1,ACER2,ATP10D,DAB2,PREX2
1.648e-02	-4.11	DCAF6 (DDB1 and CUL4 associated factor 6)	protein interactions	55827	213	3	19454	49	DAB2,ACACB,DOCK8
1.669e-02	-4.09	BAG2 (BAG cochaperone 2)	protein interactions	9532	596	5	19454	49	RAPGEF6,DISC1,TFEB,HCK,ASCC3
1.672e-02	-4.09	negative regulation of ERK1 and ERK2 cascade	biological process	GO:0070373	75	2	18204	48	PTPRC,DAB2
1.672e-02	-4.09	regulation of calcium ion transmembrane transporter activity	biological process	GO:1901019	75	2	18204	48	SLC9A1,VMP1
1.672e-02	-4.09	phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0043491	75	2	18204	48	PREX2,ATG14
1.675e-02	-4.09	human chr9p22.1	chromosome location	human chr9p22.1	9	1	26134	49	ACER2
1.675e-02	-4.09	human chr12q24.12	chromosome location	human chr12q24.12	9	1	26134	49	SH2B3
1.687e-02	-4.08	WSC	smart domains	SM00321	5	1	9717	33	KREMEN1
1.687e-02	-4.08	Biotin_carb_C	smart domains	SM00878	5	1	9717	33	ACACB
1.693e-02	-4.08	CANT1 (calcium activated nucleotidase 1)	protein interactions	124583	79	2	19454	49	TMEM131L,RHBDF2
1.710e-02	-4.07	MAGED2 (MAGE family member D2)	protein interactions	10916	216	3	19454	49	GRK6,DOCK8,PTPN6
1.713e-02	-4.07	negative regulation of cell population proliferation	biological process	GO:0008285	791	6	18204	48	TMEM131L,PTPN6,NACC2,SH2B3,PTGIR,DAB2
1.714e-02	-4.07	regulation of receptor signaling pathway via JAK-STAT	biological process	GO:0046425	76	2	18204	48	SH2B3,PTPRC
1.718e-02	-4.06	positive regulation of protein phosphorylation	biological process	GO:0001934	574	5	18204	48	DAB2,PTPRC,SYK,ATG14,CEMIP
1.721e-02	-4.06	negative regulation of phosphate metabolic process	biological process	GO:0045936	377	4	18204	48	ATG14,PTPN6,CADM4,PTPRC
1.729e-02	-4.06	GPCRKINASE	prints domains	PR00717	7	1	5227	13	GRK6
1.729e-02	-4.06	BEN domain	gene3d domains	1.10.10.2590	6	1	14470	42	NACC2
1.735e-02	-4.05	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	11	16828	46	ATP10D,SLC9A1,RBM47,OSBPL8,TMTC1,PREX2,TFEB,DAB2,HCK,ASCC3,VAV3
1.735e-02	-4.05	mucosal	COSMIC cancer mutations	mucosal	2009	11	16828	46	VAV3,HCK,ASCC3,PREX2,DAB2,TFEB,ATP10D,OSBPL8,TMTC1,SLC9A1,RBM47
1.735e-02	-4.05	SH3DOMAIN	prints domains	PR00452	83	2	5227	13	VAV3,HCK
1.736e-02	-4.05	negative regulation of phosphorus metabolic process	biological process	GO:0010563	378	4	18204	48	CADM4,PTPRC,PTPN6,ATG14
1.750e-02	-4.05	MYT1L (myelin transcription factor 1 like)	protein interactions	23040	7	1	19454	49	DISC1
1.750e-02	-4.05	LAIR1 (leukocyte associated immunoglobulin like receptor 1)	protein interactions	3903	7	1	19454	49	PTPN6
1.750e-02	-4.05	C11orf71 (chromosome 11 open reading frame 71)	protein interactions	54494	7	1	19454	49	NACC2
1.750e-02	-4.05	ZCCHC24 (zinc finger CCHC-type containing 24)	protein interactions	219654	7	1	19454	49	RBM47
1.750e-02	-4.05	XKR8 (XK related 8)	protein interactions	55113	7	1	19454	49	PTGIR
1.750e-02	-4.05	TDRD9 (tudor domain containing 9)	protein interactions	122402	7	1	19454	49	SEMA4B
1.750e-02	-4.05	SIGLEC9 (sialic acid binding Ig like lectin 9)	protein interactions	27180	7	1	19454	49	PTPN6
1.750e-02	-4.05	NSUN7 (NOP2/Sun RNA methyltransferase family member 7)	protein interactions	79730	7	1	19454	49	PTPN6
1.752e-02	-4.04	TRAF3 (TNF receptor associated factor 3)	protein interactions	7187	218	3	19454	49	VAV3,PTPN6,SYK
1.757e-02	-4.04	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	48	PLXND1,DISC1
1.757e-02	-4.04	autophagosome assembly	biological process	GO:0000045	77	2	18204	48	VMP1,ATG14
1.757e-02	-4.04	positive regulation of cell killing	biological process	GO:0031343	77	2	18204	48	PTPRC,SYK
1.761e-02	-4.04	EPHA forward signaling	Pathway Interaction DB	epha_fwdpathway	31	2	2226	15	VAV3,HCK
1.772e-02	-4.03	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	44	16828	46	ENTPD1,OSBPL8,PPP1R7,RBM47,PLXND1,RAPGEF6,SYK,STAB1,PTPRC,ASCC3,HCK,PPFIBP2,FCHO2,DOCK8,SMOX,TMTC1,GAB1,NACC2,PTPN6,ATP10D,DISC1,BLVRA,DIAPH2,ACACB,TMCC3,ATG14,SLC9A1,GALNT1,SH2B3,SEMA4B,PREX1,RHBDF2,BMP2K,PTGIR,VAV3,VMP1,DOCK2,SLC16A10,ACER2,MPP1,DAB2,TFEB,KREMEN1,PREX2
1.774e-02	-4.03	TENT5A (terminal nucleotidyltransferase 5A)	protein interactions	55603	81	2	19454	49	SYK,TMEM131L
1.776e-02	-4.03	anatomical structure development	biological process	GO:0048856	5207	21	18204	48	KREMEN1,VAV3,TFEB,GAB1,RAPGEF6,PREX1,PLXND1,SH2B3,SLC9A1,DIAPH2,VMP1,PREX2,PTPRC,SYK,DISC1,PTPN6,HCK,DAB2,RBM47,DOCK2,SEMA4B
1.776e-02	-4.03	Interferon type I signaling pathways	WikiPathways	WP585	55	2	5310	20	PTPRC,PTPN6
1.782e-02	-4.03	cortical endoplasmic reticulum	cellular component	GO:0032541	7	1	19108	49	OSBPL8
1.800e-02	-4.02	regulation of protein dephosphorylation	biological process	GO:0035304	78	2	18204	48	PTPRC,PPP1R7
1.801e-02	-4.02	vesicle-mediated transport	biological process	GO:0016192	1283	8	18204	48	HCK,DAB2,DOCK2,VAV3,SYK,FCHO2,STAB1,ATG14
1.806e-02	-4.01	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	7	19454	49	PPFIBP2,TMCC3,RAPGEF6,RHBDF2,GAB1,OSBPL8,TFEB
1.806e-02	-4.01	PTPc_motif	smart domains	SM00404	61	2	9717	33	PTPRC,PTPN6
1.818e-02	-4.01	molecular function regulator activity	molecular function	GO:0098772	2079	11	18094	48	ATG14,PTGIR,PREX1,PREX2,VAV3,DOCK2,PPP1R7,SEMA4B,RAPGEF6,BMP2K,DOCK8
1.825e-02	-4.00	ovary	COSMIC cancer mutations	ovary	14770	45	16828	46	ENTPD1,SYK,STAB1,OSBPL8,PPP1R7,PLXND1,RBM47,RAPGEF6,PPFIBP2,DOCK8,FCHO2,SMOX,ASCC3,PTPRC,HCK,BLVRA,DIAPH2,TMTC1,GAB1,PTPN6,NACC2,ATP10D,TMCC3,ACACB,GALNT1,SH2B3,SEMA4B,ATG14,GRK6,SLC9A1,VAV3,DOCK2,VMP1,PREX1,RHBDF2,BMP2K,PTGIR,DAB2,KREMEN1,TFEB,PREX2,SLC16A10,CADM4,ACER2,MPP1
1.826e-02	-4.00	EGFR (epidermal growth factor receptor)	protein interactions	1956	3105	14	19454	49	ACACB,VMP1,DAB2,SH2B3,GAB1,HCK,RHBDF2,SYK,MPP1,VAV3,PPP1R7,FCHO2,PTPN6,ASCC3
1.829e-02	-4.00	cytokine-mediated signaling pathway	biological process	GO:0019221	384	4	18204	48	SYK,PTPN6,SH2B3,HCK
1.829e-02	-4.00	WH_DNA-bd_sf	interpro domains	IPR036390	211	3	18521	49	PREX2,ASCC3,PREX1
1.832e-02	-4.00	cellular response to interleukin-3	biological process	GO:0036016	7	1	18204	48	SH2B3
1.832e-02	-4.00	platelet degranulation	biological process	GO:0002576	7	1	18204	48	SYK
1.832e-02	-4.00	response to interleukin-3	biological process	GO:0036015	7	1	18204	48	SH2B3
1.832e-02	-4.00	hyaluronan biosynthetic process	biological process	GO:0030213	7	1	18204	48	CEMIP
1.832e-02	-4.00	positive regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002925	7	1	18204	48	PTPRC
1.832e-02	-4.00	positive regulation of corticosteroid hormone secretion	biological process	GO:2000848	7	1	18204	48	DAB2
1.832e-02	-4.00	regulation of arachidonic acid secretion	biological process	GO:0090237	7	1	18204	48	SYK
1.832e-02	-4.00	regulation of ATPase-coupled calcium transmembrane transporter activity	biological process	GO:1901894	7	1	18204	48	VMP1
1.832e-02	-4.00	interleukin-3-mediated signaling pathway	biological process	GO:0038156	7	1	18204	48	SYK
1.832e-02	-4.00	macropinocytosis	biological process	GO:0044351	7	1	18204	48	DOCK2
1.832e-02	-4.00	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	biological process	GO:1902231	7	1	18204	48	NACC2
1.832e-02	-4.00	mitochondrion-endoplasmic reticulum membrane tethering	biological process	GO:1990456	7	1	18204	48	VMP1
1.832e-02	-4.00	ribosome-associated ubiquitin-dependent protein catabolic process	biological process	GO:1990116	7	1	18204	48	ASCC3
1.832e-02	-4.00	regulation of cardiac muscle cell membrane potential	biological process	GO:0086036	7	1	18204	48	SLC9A1
1.832e-02	-4.00	negative regulation of microglial cell activation	biological process	GO:1903979	7	1	18204	48	PTPRC
1.834e-02	-4.00	positive regulation of monoatomic ion transport	biological process	GO:0043270	212	3	18204	48	VMP1,SLC9A1,CEMIP
1.835e-02	-4.00	endoplasmic reticulum-Golgi intermediate compartment membrane	cellular component	GO:0033116	81	2	19108	49	VMP1,GALNT1
1.838e-02	-4.00	CbamoylP_synth_lsu-like_ATP-bd	interpro domains	IPR005479	7	1	18521	49	ACACB
1.838e-02	-4.00	GPCR_kinase	interpro domains	IPR000239	7	1	18521	49	GRK6
1.838e-02	-4.00	ILEI/PANDER_dom	interpro domains	IPR039477	7	1	18521	49	CEMIP
1.838e-02	-4.00	U2A'_phosphoprotein32A_C	interpro domains	IPR003603	7	1	18521	49	PPP1R7
1.838e-02	-4.00	PDGFRB (platelet derived growth factor receptor beta)	protein interactions	5159	222	3	19454	49	VAV3,GAB1,PTPN6
1.839e-02	-4.00	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	45	16828	46	DOCK2,VMP1,VAV3,PREX1,PTGIR,BMP2K,RHBDF2,KREMEN1,TFEB,DAB2,PREX2,SLC16A10,MPP1,ACER2,CADM4,TMCC3,ACACB,GALNT1,SEMA4B,SH2B3,GRK6,SLC9A1,ATG14,DOCK8,FCHO2,PPFIBP2,SMOX,ASCC3,PTPRC,HCK,DISC1,BLVRA,DIAPH2,TMTC1,ATP10D,GAB1,NACC2,PTPN6,ENTPD1,SYK,STAB1,RBM47,PLXND1,PPP1R7,RAPGEF6
1.839e-02	-4.00	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	45	16828	46	GAB1,PTPN6,NACC2,ATP10D,TMTC1,DIAPH2,BLVRA,DISC1,HCK,PTPRC,ASCC3,SMOX,PPFIBP2,FCHO2,DOCK8,RAPGEF6,PPP1R7,PLXND1,RBM47,STAB1,SYK,ENTPD1,CADM4,MPP1,ACER2,SLC16A10,PREX2,DAB2,TFEB,KREMEN1,RHBDF2,PTGIR,BMP2K,PREX1,VAV3,VMP1,DOCK2,ATG14,SLC9A1,GRK6,SH2B3,SEMA4B,GALNT1,ACACB,TMCC3
1.839e-02	-4.00	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	45	16828	46	ATG14,SLC9A1,GRK6,SH2B3,SEMA4B,GALNT1,ACACB,TMCC3,CADM4,MPP1,ACER2,SLC16A10,PREX2,DAB2,TFEB,KREMEN1,RHBDF2,BMP2K,PTGIR,PREX1,VAV3,VMP1,DOCK2,RAPGEF6,RBM47,PPP1R7,PLXND1,STAB1,SYK,ENTPD1,NACC2,GAB1,PTPN6,ATP10D,TMTC1,BLVRA,DIAPH2,DISC1,HCK,PTPRC,ASCC3,SMOX,PPFIBP2,FCHO2,DOCK8
1.839e-02	-4.00	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	45	16828	46	TMCC3,ACACB,GALNT1,SEMA4B,SH2B3,SLC9A1,GRK6,ATG14,DOCK2,VMP1,VAV3,PREX1,BMP2K,PTGIR,RHBDF2,KREMEN1,TFEB,DAB2,PREX2,SLC16A10,MPP1,ACER2,CADM4,ENTPD1,SYK,STAB1,PLXND1,PPP1R7,RBM47,RAPGEF6,DOCK8,FCHO2,PPFIBP2,SMOX,ASCC3,PTPRC,HCK,DISC1,BLVRA,DIAPH2,TMTC1,ATP10D,NACC2,GAB1,PTPN6
1.843e-02	-3.99	G protein-coupled receptor kinase activity	molecular function	GO:0004703	7	1	18094	48	GRK6
1.843e-02	-3.99	N-acylsphingosine amidohydrolase activity	molecular function	GO:0017040	7	1	18094	48	ACER2
1.843e-02	-3.99	ligase activity, forming carbon-carbon bonds	molecular function	GO:0016885	7	1	18094	48	ACACB
1.844e-02	-3.99	myeloid cell development	biological process	GO:0061515	79	2	18204	48	SH2B3,PTPN6
1.844e-02	-3.99	classic	COSMIC cancer mutations	classic	14774	45	16828	46	RHBDF2,BMP2K,PTGIR,PREX1,VAV3,DOCK2,VMP1,CADM4,MPP1,ACER2,SLC16A10,PREX2,DAB2,KREMEN1,TFEB,ACACB,TMCC3,ATG14,SLC9A1,GRK6,SH2B3,SEMA4B,GALNT1,HCK,ASCC3,PTPRC,SMOX,PPFIBP2,DOCK8,FCHO2,PTPN6,NACC2,GAB1,ATP10D,TMTC1,DIAPH2,BLVRA,DISC1,ENTPD1,RAPGEF6,PPP1R7,RBM47,PLXND1,STAB1,SYK
1.847e-02	-3.99	AP2M1 (adaptor related protein complex 2 subunit mu 1)	protein interactions	1173	403	4	19454	49	DAB2,FCHO2,MPP1,BMP2K
1.847e-02	-3.99	CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2)	protein interactions	830	403	4	19454	49	BMP2K,VMP1,DAB2,FCHO2
1.853e-02	-3.99	Heme degradation	REACTOME pathways	R-HSA-189483	6	1	10285	32	BLVRA
1.853e-02	-3.99	CD22 mediated BCR regulation	REACTOME pathways	R-HSA-5690714	6	1	10285	32	PTPN6
1.853e-02	-3.99	MET activates PI3K/AKT signaling	REACTOME pathways	R-HSA-8851907	6	1	10285	32	GAB1
1.853e-02	-3.99	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	REACTOME pathways	R-HSA-5339717	6	1	10285	32	KREMEN1
1.857e-02	-3.99	CPSASE_2	prosite domains	PS00867	6	1	12186	38	ACACB
1.858e-02	-3.99	ENTREP1 (endosomal transmembrane epsin interactor 1)	protein interactions	9413	83	2	19454	49	RHBDF2,SLC9A1
1.858e-02	-3.99	N4BP2 (NEDD4 binding protein 2)	protein interactions	55728	83	2	19454	49	RBM47,DISC1
1.858e-02	-3.99	NEXN (nexilin F-actin binding protein)	protein interactions	91624	83	2	19454	49	DISC1,VMP1
1.864e-02	-3.98	medulla	COSMIC cancer mutations	medulla	14778	45	16828	46	SYK,STAB1,RBM47,PLXND1,PPP1R7,RAPGEF6,ENTPD1,DISC1,DIAPH2,BLVRA,TMTC1,ATP10D,GAB1,PTPN6,NACC2,DOCK8,FCHO2,PPFIBP2,SMOX,ASCC3,PTPRC,HCK,GALNT1,SEMA4B,SH2B3,SLC9A1,GRK6,ATG14,TMCC3,ACACB,KREMEN1,TFEB,DAB2,PREX2,SLC16A10,ACER2,MPP1,CADM4,DOCK2,VMP1,VAV3,PREX1,BMP2K,PTGIR,RHBDF2
1.869e-02	-3.98	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	45	16828	46	ENTPD1,STAB1,SYK,RAPGEF6,PPP1R7,PLXND1,RBM47,SMOX,FCHO2,DOCK8,PPFIBP2,HCK,PTPRC,ASCC3,BLVRA,DIAPH2,DISC1,ATP10D,NACC2,GAB1,PTPN6,TMTC1,TMCC3,ACACB,SEMA4B,SH2B3,GALNT1,GRK6,SLC9A1,ATG14,VMP1,DOCK2,VAV3,PTGIR,BMP2K,RHBDF2,PREX1,PREX2,TFEB,KREMEN1,DAB2,MPP1,ACER2,CADM4,SLC16A10
1.871e-02	-3.98	Osteopontin-mediated events	Pathway Interaction DB	avb3_opn_pathway	32	2	2226	15	VAV3,SYK
1.871e-02	-3.98	Alpha-synuclein signaling	Pathway Interaction DB	alphasynuclein_pathway	32	2	2226	15	SYK,HCK
1.873e-02	-3.98	CPSase_L_D2	pfam domains	PF02786	7	1	17795	48	ACACB
1.873e-02	-3.98	ILEI	pfam domains	PF15711	7	1	17795	48	CEMIP
1.880e-02	-3.97	Semaphorin interactions	REACTOME pathways	R-HSA-373755	68	2	10285	32	PLXND1,PTPRC
1.881e-02	-3.97	clathrin-coated vesicle	cellular component	GO:0030136	220	3	19108	49	FCHO2,DAB2,CEMIP
1.885e-02	-3.97	RAC3 (Rac family small GTPase 3)	protein interactions	5881	615	5	19454	49	GAB1,OSBPL8,DIAPH2,SLC9A1,FCHO2
1.898e-02	-3.96	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	46	PREX2
1.898e-02	-3.96	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	46	PREX2
1.900e-02	-3.96	KRTAP3-1 (keratin associated protein 3-1)	protein interactions	83896	84	2	19454	49	HCK,DOCK2
1.900e-02	-3.96	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	49	SYK,HCK
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	HCK,ENTPD1
1.939e-02	-3.94	LIMA1 (LIM domain and actin binding 1)	protein interactions	51474	409	4	19454	49	DISC1,FCHO2,DAB2,BMP2K
1.943e-02	-3.94	WSB2 (WD repeat and SOCS box containing 2)	protein interactions	55884	85	2	19454	49	PREX1,ACACB
1.943e-02	-3.94	ABRAXAS2 (abraxas 2, BRISC complex subunit)	protein interactions	23172	85	2	19454	49	SH2B3,SYK
1.948e-02	-3.94	PRKCD (protein kinase C delta)	protein interactions	5580	227	3	19454	49	DAB2,BLVRA,PTPN6
1.948e-02	-3.94	MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)	protein interactions	9448	227	3	19454	49	SLC9A1,DISC1,ATG14
1.954e-02	-3.94	LDLR (low density lipoprotein receptor)	protein interactions	3949	410	4	19454	49	SLC16A10,PREX2,FCHO2,DAB2
1.959e-02	-3.93	transport	biological process	GO:0006810	3615	16	18204	48	ATG14,FCHO2,STAB1,VAV3,ACACB,SYK,PTPRC,ATP10D,OSBPL8,SLC9A1,VMP1,SLC16A10,DOCK2,RHBDF2,DAB2,HCK
1.973e-02	-3.93	regulation of metal ion transport	biological process	GO:0010959	393	4	18204	48	CEMIP,PTPN6,VMP1,SLC9A1
1.974e-02	-3.93	PROSTANOIDR	prints domains	PR01788	8	1	5227	13	PTGIR
1.975e-02	-3.92	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	45	16828	46	PREX1,BMP2K,PTGIR,RHBDF2,VMP1,DOCK2,VAV3,SLC16A10,MPP1,ACER2,TFEB,KREMEN1,DAB2,PREX2,ACACB,TMCC3,GRK6,SLC9A1,ATG14,GALNT1,SEMA4B,SH2B3,PTPRC,ASCC3,HCK,FCHO2,DOCK8,PPFIBP2,SMOX,TMTC1,ATP10D,NACC2,GAB1,PTPN6,DISC1,BLVRA,DIAPH2,ENTPD1,PPP1R7,RBM47,PLXND1,OSBPL8,RAPGEF6,SYK,STAB1
1.975e-02	-3.92	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	45	16828	46	TMCC3,ACACB,GALNT1,SH2B3,SEMA4B,ATG14,SLC9A1,GRK6,VAV3,DOCK2,VMP1,PREX1,RHBDF2,BMP2K,PTGIR,DAB2,KREMEN1,TFEB,PREX2,SLC16A10,MPP1,ACER2,ENTPD1,SYK,STAB1,OSBPL8,RBM47,PLXND1,PPP1R7,RAPGEF6,PPFIBP2,DOCK8,FCHO2,SMOX,ASCC3,PTPRC,HCK,DISC1,DIAPH2,BLVRA,TMTC1,PTPN6,NACC2,GAB1,ATP10D
1.985e-02	-3.92	UTP and CTP dephosphorylation II	BIOCYC pathways	META_PWY-7177	3	1	902	6	ENTPD1
1.985e-02	-3.92	UTP and CTP dephosphorylation I	BIOCYC pathways	META_PWY-7185	3	1	902	6	ENTPD1
1.985e-02	-3.92	biotin-carboxyl carrier protein assembly	BIOCYC pathways	HUMAN_PWY0-1264	3	1	902	6	ACACB
1.998e-02	-3.91	LILRB1 (leukocyte immunoglobulin like receptor B1)	protein interactions	10859	8	1	19454	49	PTPN6
1.998e-02	-3.91	KMO (kynurenine 3-monooxygenase)	protein interactions	8564	8	1	19454	49	DISC1
1.998e-02	-3.91	TREML1 (triggering receptor expressed on myeloid cells like 1)	protein interactions	340205	8	1	19454	49	PTPN6
1.998e-02	-3.91	CD1D (CD1d molecule)	protein interactions	912	8	1	19454	49	PTPRC
1.998e-02	-3.91	C14orf93 (chromosome 14 open reading frame 93)	protein interactions	60686	8	1	19454	49	PPFIBP2
1.998e-02	-3.91	LRRC58 (leucine rich repeat containing 58)	protein interactions	116064	8	1	19454	49	ATG14
1.998e-02	-3.91	BCDIN3D (BCDIN3 domain containing RNA methyltransferase)	protein interactions	144233	8	1	19454	49	ACACB
1.998e-02	-3.91	RNPEPL1 (arginyl aminopeptidase like 1)	protein interactions	57140	8	1	19454	49	TMCC3
2.000e-02	-3.91	receptor tyrosine kinase binding	molecular function	GO:0030971	82	2	18094	48	SH2B3,CADM4
2.016e-02	-3.90	DST (dystonin)	protein interactions	667	230	3	19454	49	DISC1,VMP1,RHBDF2
2.023e-02	-3.90	positive regulation of ion transmembrane transporter activity	biological process	GO:0032414	83	2	18204	48	VMP1,SLC9A1
2.023e-02	-3.90	nucleoside diphosphate metabolic process	biological process	GO:0009132	83	2	18204	48	MPP1,ENTPD1
2.034e-02	-3.90	presynaptic endocytic zone membrane	cellular component	GO:0098835	8	1	19108	49	FCHO2
2.034e-02	-3.90	phosphatidylinositol 3-kinase complex, class III	cellular component	GO:0035032	8	1	19108	49	ATG14
2.039e-02	-3.89	CALD1 (caldesmon 1)	protein interactions	800	231	3	19454	49	DOCK8,DISC1,VMP1
2.049e-02	-3.89	SRP9 (signal recognition particle 9)	protein interactions	6726	416	4	19454	49	ASCC3,OSBPL8,MPP1,VMP1
2.049e-02	-3.89	TMPRSS11B (transmembrane serine protease 11B)	protein interactions	132724	416	4	19454	49	SLC9A1,GALNT1,SLC16A10,OSBPL8
2.065e-02	-3.88	forearm	COSMIC cancer mutations	forearm	81	2	16828	46	PREX2,PTPRC
2.069e-02	-3.88	autophagosome organization	biological process	GO:1905037	84	2	18204	48	ATG14,VMP1
2.069e-02	-3.88	stem cell development	biological process	GO:0048864	84	2	18204	48	SEMA4B,PTPRC
2.069e-02	-3.88	membrane docking	biological process	GO:0022406	84	2	18204	48	VMP1,ATG14
2.069e-02	-3.88	regulation of release of sequestered calcium ion into cytosol	biological process	GO:0051279	84	2	18204	48	CEMIP,PTPN6
2.075e-02	-3.88	cellular component biogenesis	biological process	GO:0044085	2716	13	18204	48	DISC1,SLC9A1,NACC2,DIAPH2,VMP1,DAB2,ATG14,RAPGEF6,FCHO2,VAV3,PREX1,ACACB,PLXND1
2.090e-02	-3.87	regulation of neutrophil degranulation	biological process	GO:0043313	8	1	18204	48	SYK
2.090e-02	-3.87	regulation of aldosterone biosynthetic process	biological process	GO:0032347	8	1	18204	48	DAB2
2.090e-02	-3.87	lactate transport	biological process	GO:0015727	8	1	18204	48	ACACB
2.090e-02	-3.87	regulation of aldosterone metabolic process	biological process	GO:0032344	8	1	18204	48	DAB2
2.090e-02	-3.87	positive regulation of killing of cells of another organism	biological process	GO:0051712	8	1	18204	48	SYK
2.090e-02	-3.87	positive regulation of action potential	biological process	GO:0045760	8	1	18204	48	SLC9A1
2.090e-02	-3.87	lactate transmembrane transport	biological process	GO:0035873	8	1	18204	48	ACACB
2.090e-02	-3.87	dichotomous subdivision of an epithelial terminal unit	biological process	GO:0060600	8	1	18204	48	PLXND1
2.092e-02	-3.87	phosphatidylinositol-4,5-bisphosphate binding	molecular function	GO:0005546	84	2	18094	48	SLC9A1,FCHO2
2.097e-02	-3.86	Pectin_lyase_fold/virulence	interpro domains	IPR011050	8	1	18521	49	CEMIP
2.097e-02	-3.86	GDA1_CD39_NTPase	interpro domains	IPR000407	8	1	18521	49	ENTPD1
2.097e-02	-3.86	Prostanoid_rcpt	interpro domains	IPR008365	8	1	18521	49	PTGIR
2.097e-02	-3.86	TIG1_plexin	interpro domains	IPR041019	8	1	18521	49	PLXND1
2.097e-02	-3.86	DAD_dom	interpro domains	IPR014767	8	1	18521	49	DIAPH2
2.101e-02	-3.86	cellular metabolic process	biological process	GO:0044237	5975	23	18204	48	MPP1,ACER2,PREX1,TFEB,TMTC1,ATG14,BMP2K,PHKB,GRK6,GALNT1,HCK,OSBPL8,VMP1,SMOX,ENTPD1,ASCC3,ACACB,CEMIP,RBM47,SLC16A10,SYK,PTPRC,PTPN6
2.103e-02	-3.86	dolichyl-phosphate-mannose-protein mannosyltransferase activity	molecular function	GO:0004169	8	1	18094	48	TMTC1
2.103e-02	-3.86	thyroid hormone transmembrane transporter activity	molecular function	GO:0015349	8	1	18094	48	SLC16A10
2.103e-02	-3.86	phosphorylation-dependent protein binding	molecular function	GO:0140031	8	1	18094	48	PTPN6
2.103e-02	-3.86	hyalurononglucosaminidase activity	molecular function	GO:0004415	8	1	18094	48	CEMIP
2.109e-02	-3.86	PRKCB (protein kinase C beta)	protein interactions	5579	234	3	19454	49	BLVRA,DAB2,OSBPL8
2.110e-02	-3.86	TYR_PHOSPHATASE_1	prosite domains	PS00383	72	2	12186	38	PTPN6,PTPRC
2.117e-02	-3.85	INSRR (insulin receptor related receptor)	protein interactions	3645	89	2	19454	49	RHBDF2,OSBPL8
2.124e-02	-3.85	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	16	16828	46	ASCC3,PTPRC,ACACB,VAV3,DOCK8,DOCK2,TMCC3,TMTC1,OSBPL8,SLC9A1,PLXND1,SLC16A10,RAPGEF6,DAB2,DIAPH2,PREX2
2.133e-02	-3.85	LAMP1 (lysosomal associated membrane protein 1)	protein interactions	3916	635	5	19454	49	SLC16A10,OSBPL8,PPFIBP2,FCHO2,DISC1
2.135e-02	-3.85	middle_third	COSMIC cancer mutations	middle_third	3533	16	16828	46	DOCK8,DOCK2,VAV3,TMCC3,PTPRC,ASCC3,ACACB,DAB2,PREX2,DIAPH2,PLXND1,SLC16A10,SLC9A1,OSBPL8,TMTC1,RAPGEF6
2.138e-02	-3.85	GDA1_CD39	pfam domains	PF01150	8	1	17795	48	ENTPD1
2.138e-02	-3.85	TIG_plexin	pfam domains	PF17960	8	1	17795	48	PLXND1
2.143e-02	-3.84	uveal_tract	COSMIC cancer mutations	uveal_tract	587	5	16828	46	PREX2,PLXND1,GRK6,PREX1,PTPRC
2.158e-02	-3.84	Reversal of alkylation damage by DNA dioxygenases	REACTOME pathways	R-HSA-73943	7	1	10285	32	ASCC3
2.162e-02	-3.83	malignant	COSMIC cancer mutations	malignant	83	2	16828	46	GALNT1,ASCC3
2.163e-02	-3.83	GG_LECTIN	prosite domains	PS52031	7	1	12186	38	CEMIP
2.163e-02	-3.83	STX4 (syntaxin 4)	protein interactions	6810	423	4	19454	49	SLC9A1,TMCC3,GAB1,OSBPL8
2.166e-02	-3.83	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	46	PREX2
2.166e-02	-3.83	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	8	1	16828	46	NACC2
2.168e-02	-3.83	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	10	16828	46	TMTC1,ATG14,SLC9A1,PTPN6,RAPGEF6,ATP10D,DOCK2,DOCK8,STAB1,ENTPD1
2.168e-02	-3.83	functioning	COSMIC cancer mutations	functioning	1803	10	16828	46	SLC9A1,ATG14,TMTC1,ATP10D,RAPGEF6,PTPN6,DOCK2,DOCK8,ENTPD1,STAB1
2.176e-02	-3.83	Tyr_Pase_dom	interpro domains	IPR000387	86	2	18521	49	PTPN6,PTPRC
2.204e-02	-3.81	SNAP29 (synaptosome associated protein 29)	protein interactions	9342	238	3	19454	49	ATG14,RHBDF2,PPFIBP2
2.206e-02	-3.81	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	11	16828	46	BMP2K,HCK,GRK6,PLXND1,PTPRC,PREX2,STAB1,SYK,TFEB,GALNT1,DAB2
2.207e-02	-3.81	TRIO (trio Rho guanine nucleotide exchange factor)	protein interactions	7204	91	2	19454	49	DISC1,DAB2
2.218e-02	-3.81	NAHEXCHNGR	prints domains	PR01084	9	1	5227	13	SLC9A1
2.222e-02	-3.81	regulation of cell development	biological process	GO:0060284	839	6	18204	48	PTPN6,PTPRC,DISC1,SYK,TMEM131L,PLXND1
2.227e-02	-3.80	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection	WikiPathways	WP3863	62	2	5310	20	PTPN6,PTPRC
2.227e-02	-3.80	human chr12p11.22	chromosome location	human chr12p11.22	12	1	26134	49	TMTC1
2.230e-02	-3.80	ORF8 (ORF8 protein)	protein interactions	43740577	427	4	19454	49	OSBPL8,GALNT1,CEMIP,ACACB
2.232e-02	-3.80	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	36	16828	46	SH2B3,STAB1,SEMA4B,GALNT1,RAPGEF6,ATG14,OSBPL8,PPP1R7,PLXND1,SLC9A1,TMCC3,ACACB,PREX2,BLVRA,DIAPH2,DAB2,KREMEN1,GAB1,CADM4,NACC2,MPP1,ACER2,ATP10D,TMTC1,SLC16A10,PPFIBP2,VAV3,VMP1,DOCK2,DOCK8,HCK,RHBDF2,PTGIR,PTPRC,ASCC3,PREX1
2.243e-02	-3.80	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	5	16828	46	DAB2,ASCC3,PREX2,DIAPH2,ACACB
2.245e-02	-3.80	NPAP1 (nuclear pore associated protein 1)	protein interactions	23742	9	1	19454	49	ACACB
2.245e-02	-3.80	AIFM3 (apoptosis inducing factor mitochondria associated 3)	protein interactions	150209	9	1	19454	49	GRK6
2.245e-02	-3.80	RBM46 (RNA binding motif protein 46)	protein interactions	166863	9	1	19454	49	RBM47
2.245e-02	-3.80	LILRB2 (leukocyte immunoglobulin like receptor B2)	protein interactions	10288	9	1	19454	49	PTPN6
2.245e-02	-3.80	SEMA3A (semaphorin 3A)	protein interactions	10371	9	1	19454	49	DISC1
2.245e-02	-3.80	CALCB (calcitonin related polypeptide beta)	protein interactions	797	9	1	19454	49	ATG14
2.245e-02	-3.80	TSSK4 (testis specific serine kinase 4)	protein interactions	283629	9	1	19454	49	ACACB
2.245e-02	-3.80	PPFIA4 (PTPRF interacting protein alpha 4)	protein interactions	8497	9	1	19454	49	DISC1
2.245e-02	-3.80	Ppp1r3b (protein phosphatase 1, regulatory subunit 3B)	protein interactions	244416	9	1	19454	49	PHKB
2.245e-02	-3.80	PCNX4 (pecanex 4)	protein interactions	64430	9	1	19454	49	DISC1
2.245e-02	-3.80	PEAR1 (platelet endothelial aggregation receptor 1)	protein interactions	375033	9	1	19454	49	SYK
2.245e-02	-3.80	SLN (sarcolipin)	protein interactions	6588	9	1	19454	49	VMP1
2.251e-02	-3.79	trunk	COSMIC cancer mutations	trunk	3554	16	16828	46	ACACB,HCK,ASCC3,PTPRC,DOCK2,DOCK8,CADM4,ATP10D,SLC9A1,RBM47,STAB1,PREX2,DAB2,DISC1,SYK,TFEB
2.262e-02	-3.79	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	23	16828	46	TMTC1,PLXND1,GRK6,SLC16A10,NACC2,PTPN6,GAB1,ATP10D,DAB2,KREMEN1,SH2B3,PREX2,DIAPH2,SEMA4B,PTPRC,ASCC3,ACACB,PPFIBP2,VAV3,VMP1,DOCK8,DOCK2,ENTPD1
2.268e-02	-3.79	regulation of defense response	biological process	GO:0031347	843	6	18204	48	HCK,RBM47,RHBDF2,SYK,PTPRC,PTPN6
2.285e-02	-3.78	bleb	cellular component	GO:0032059	9	1	19108	49	PTPRC
2.285e-02	-3.78	presynaptic endocytic zone	cellular component	GO:0098833	9	1	19108	49	FCHO2
2.299e-02	-3.77	positive regulation of phosphorylation	biological process	GO:0042327	619	5	18204	48	DAB2,ATG14,CEMIP,PTPRC,SYK
2.299e-02	-3.77	-	gene3d domains	3.90.660.10	8	1	14470	42	SMOX
2.299e-02	-3.77	Exopolyphosphatase. Domain 2	gene3d domains	3.30.420.150	8	1	14470	42	ENTPD1
2.302e-02	-3.77	ATG16L1 (autophagy related 16 like 1)	protein interactions	55054	1138	7	19454	49	OSBPL8,TFEB,DOCK2,ASCC3,SYK,PTPRC,ACACB
2.305e-02	-3.77	negative regulation of lymphocyte proliferation	biological process	GO:0050672	89	2	18204	48	PTPN6,TMEM131L
2.316e-02	-3.77	Cell death signalling via NRAGE, NRIF and NADE	REACTOME pathways	R-HSA-204998	76	2	10285	32	VAV3,PREX1
2.331e-02	-3.76	SHMT2 (serine hydroxymethyltransferase 2)	protein interactions	6472	650	5	19454	49	GRK6,RAPGEF6,DOCK8,CADM4,PREX1
2.342e-02	-3.75	WH-like_DNA-bd_sf	interpro domains	IPR036388	232	3	18521	49	ASCC3,PREX1,PREX2
2.345e-02	-3.75	DIP2A (disco interacting protein 2 homolog A)	protein interactions	23181	94	2	19454	49	DAB2,CADM4
2.349e-02	-3.75	negative regulation of chemokine-mediated signaling pathway	biological process	GO:0070100	9	1	18204	48	SH2B3
2.349e-02	-3.75	negative regulation of protein autophosphorylation	biological process	GO:0031953	9	1	18204	48	PTPRC
2.349e-02	-3.75	intracellular amino acid homeostasis	biological process	GO:0080144	9	1	18204	48	ACACB
2.349e-02	-3.75	positive regulation of hormone biosynthetic process	biological process	GO:0046886	9	1	18204	48	DAB2
2.349e-02	-3.75	negative regulation of inflammatory response to wounding	biological process	GO:0106015	9	1	18204	48	PTPN6
2.349e-02	-3.75	positive regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000096	9	1	18204	48	DAB2
2.349e-02	-3.75	positive regulation of early endosome to late endosome transport	biological process	GO:2000643	9	1	18204	48	DAB2
2.349e-02	-3.75	bone marrow development	biological process	GO:0048539	9	1	18204	48	PTPRC
2.349e-02	-3.75	respiratory burst involved in defense response	biological process	GO:0002679	9	1	18204	48	HCK
2.349e-02	-3.75	antibacterial innate immune response	biological process	GO:0140367	9	1	18204	48	TFEB
2.349e-02	-3.75	regulation of killing of cells of another organism	biological process	GO:0051709	9	1	18204	48	SYK
2.349e-02	-3.75	phosphatidylserine acyl-chain remodeling	biological process	GO:0036150	9	1	18204	48	OSBPL8
2.349e-02	-3.75	establishment of T cell polarity	biological process	GO:0001768	9	1	18204	48	DOCK2
2.354e-02	-3.75	LRRcap	smart domains	SM00446	7	1	9717	33	PPP1R7
2.357e-02	-3.75	Plexin_cytoplasmic_RasGAP_dom	interpro domains	IPR013548	9	1	18521	49	PLXND1
2.357e-02	-3.75	NaH_exchanger	interpro domains	IPR004709	9	1	18521	49	SLC9A1
2.357e-02	-3.75	GTPase-bd	interpro domains	IPR010473	9	1	18521	49	DIAPH2
2.357e-02	-3.75	Peptidase_S54_rhomboid_dom	interpro domains	IPR022764	9	1	18521	49	RHBDF2
2.357e-02	-3.75	FH3_dom	interpro domains	IPR010472	9	1	18521	49	DIAPH2
2.357e-02	-3.75	BEN_domain	interpro domains	IPR018379	9	1	18521	49	NACC2
2.357e-02	-3.75	Plexin_RBD	interpro domains	IPR046800	9	1	18521	49	PLXND1
2.363e-02	-3.75	vascular endothelial growth factor receptor 2 binding	molecular function	GO:0043184	9	1	18094	48	CADM4
2.363e-02	-3.75	UDP phosphatase activity	molecular function	GO:0045134	9	1	18094	48	ENTPD1
2.363e-02	-3.75	guanylate kinase activity	molecular function	GO:0004385	9	1	18094	48	MPP1
2.363e-02	-3.75	focal adhesion	cellular component	GO:0005925	427	4	19108	49	DAB2,PTPRC,HCK,SLC9A1
2.373e-02	-3.74	TYRKINASE	prints domains	PR00109	98	2	5227	13	SYK,HCK
2.381e-02	-3.74	cell leading edge	cellular component	GO:0031252	428	4	19108	49	PLXND1,CADM4,SLC9A1,DOCK8
2.399e-02	-3.73	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	48	HCK,DAB2,SH2B3,GAB1,SYK
2.402e-02	-3.73	Drf_FH3	pfam domains	PF06367	9	1	17795	48	DIAPH2
2.402e-02	-3.73	Drf_GBD	pfam domains	PF06371	9	1	17795	48	DIAPH2
2.402e-02	-3.73	Plexin_cytopl	pfam domains	PF08337	9	1	17795	48	PLXND1
2.402e-02	-3.73	Rhomboid	pfam domains	PF01694	9	1	17795	48	RHBDF2
2.402e-02	-3.73	Biotin_lipoyl	pfam domains	PF00364	9	1	17795	48	ACACB
2.402e-02	-3.73	BEN	pfam domains	PF10523	9	1	17795	48	NACC2
2.402e-02	-3.73	Plexin_RBD	pfam domains	PF20170	9	1	17795	48	PLXND1
2.402e-02	-3.73	negative regulation of mononuclear cell proliferation	biological process	GO:0032945	91	2	18204	48	TMEM131L,PTPN6
2.421e-02	-3.72	eye	COSMIC cancer mutations	eye	606	5	16828	46	PREX2,PTPRC,PREX1,GRK6,PLXND1
2.434e-02	-3.72	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	46	PREX2
2.434e-02	-3.72	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	46	PREX2
2.439e-02	-3.71	GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)	protein interactions	8729	439	4	19454	49	DAB2,ASCC3,TMEM131L,PTPN6
2.451e-02	-3.71	response to chemokine	biological process	GO:1990868	92	2	18204	48	SH2B3,DOCK8
2.451e-02	-3.71	positive regulation of transporter activity	biological process	GO:0032411	92	2	18204	48	SLC9A1,VMP1
2.451e-02	-3.71	cellular response to chemokine	biological process	GO:1990869	92	2	18204	48	DOCK8,SH2B3
2.452e-02	-3.71	ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)	protein interactions	25	248	3	19454	49	HCK,PTPN6,BMP2K
2.463e-02	-3.70	Phosphate bond hydrolysis by NTPDase proteins	REACTOME pathways	R-HSA-8850843	8	1	10285	32	ENTPD1
2.463e-02	-3.70	DNA Damage Reversal	REACTOME pathways	R-HSA-73942	8	1	10285	32	ASCC3
2.466e-02	-3.70	negative regulation of protein modification process	biological process	GO:0031400	421	4	18204	48	PTPRC,CADM4,ATG14,PTPN6
2.468e-02	-3.70	GDA1_CD39_NTPASE	prosite domains	PS01238	8	1	12186	38	ENTPD1
2.468e-02	-3.70	DAD	prosite domains	PS51231	8	1	12186	38	DIAPH2
2.478e-02	-3.70	MYO19 (myosin XIX)	protein interactions	80179	249	3	19454	49	BMP2K,DAB2,FCHO2
2.479e-02	-3.70	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	48	FCHO2,RHBDF2,RAPGEF6
2.484e-02	-3.70	vesicle	cellular component	GO:0031982	4141	17	19108	49	DISC1,FCHO2,ATG14,SLC9A1,RAPGEF6,SYK,ENTPD1,HCK,CEMIP,DIAPH2,BLVRA,PTPRC,DOCK2,DAB2,PTPN6,STAB1,PPP1R7
2.486e-02	-3.69	Tpm1 (tropomyosin 1, alpha)	protein interactions	22003	97	2	19454	49	BMP2K,DAB2
2.486e-02	-3.69	CBLB (Cbl proto-oncogene B)	protein interactions	868	97	2	19454	49	VAV3,SYK
2.491e-02	-3.69	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	11	16828	46	DAB2,VAV3,PPFIBP2,DOCK2,DIAPH2,PREX2,TMTC1,PTPRC,SLC9A1,PPP1R7,GAB1
2.491e-02	-3.69	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	11	16828	46	DAB2,DIAPH2,PREX2,TMTC1,SLC9A1,PPP1R7,GAB1,VAV3,PPFIBP2,DOCK2,PTPRC
2.491e-02	-3.69	MACC1 (MET transcriptional regulator MACC1)	protein interactions	346389	10	1	19454	49	FCHO2
2.491e-02	-3.69	SIGLEC7 (sialic acid binding Ig like lectin 7)	protein interactions	27036	10	1	19454	49	PTPN6
2.491e-02	-3.69	SIGLEC10 (sialic acid binding Ig like lectin 10)	protein interactions	89790	10	1	19454	49	PTPN6
2.491e-02	-3.69	N (nucleocapsid protein)	protein interactions	14254601	10	1	19454	49	PPP1R7
2.491e-02	-3.69	ATRAID (all-trans retinoic acid induced differentiation factor)	protein interactions	51374	10	1	19454	49	MPP1
2.491e-02	-3.69	PTPRT (protein tyrosine phosphatase receptor type T)	protein interactions	11122	10	1	19454	49	PHKB
2.491e-02	-3.69	PRTG (protogenin)	protein interactions	283659	10	1	19454	49	DISC1
2.491e-02	-3.69	Gbf1 (golgi-specific brefeldin A-resistance factor 1)	protein interactions	107338	10	1	19454	49	SLC9A1
2.491e-02	-3.69	HAS1 (hyaluronan synthase 1)	protein interactions	3036	10	1	19454	49	CEMIP
2.491e-02	-3.69	BECN2 (beclin 2)	protein interactions	441925	10	1	19454	49	ATG14
2.491e-02	-3.69	METTL26 (methyltransferase like 26)	protein interactions	84326	10	1	19454	49	DISC1
2.498e-02	-3.69	response to lipid	biological process	GO:0033993	862	6	18204	48	PTPRC,SYK,DAB2,ACER2,HCK,PTGIR
2.501e-02	-3.69	regulation of receptor signaling pathway via STAT	biological process	GO:1904892	93	2	18204	48	SH2B3,PTPRC
2.510e-02	-3.68	developmental process	biological process	GO:0032502	5716	22	18204	48	SH2B3,PREX1,TFEB,GAB1,HCK,DAB2,OSBPL8,VMP1,DIAPH2,PLXND1,RAPGEF6,KREMEN1,VAV3,SEMA4B,RBM47,DOCK2,PTPN6,DISC1,PTPRC,SYK,PREX2,SLC9A1
2.529e-02	-3.68	STX6 (syntaxin 6)	protein interactions	10228	444	4	19454	49	BMP2K,DAB2,GAB1,OSBPL8
2.534e-02	-3.68	PTK2B (protein tyrosine kinase 2 beta)	protein interactions	2185	98	2	19454	49	PTPN6,SYK
2.534e-02	-3.68	VAV2 (vav guanine nucleotide exchange factor 2)	protein interactions	7410	98	2	19454	49	GAB1,SYK
2.534e-02	-3.68	GPRC5B (G protein-coupled receptor class C group 5 member B)	protein interactions	51704	98	2	19454	49	ACACB,RHBDF2
2.536e-02	-3.67	immunoglobulin complex	cellular component	GO:0019814	10	1	19108	49	SYK
2.542e-02	-3.67	regulation of hemopoiesis	biological process	GO:1903706	425	4	18204	48	PTPN6,PTPRC,TMEM131L,SYK
2.542e-02	-3.67	leukocyte differentiation	biological process	GO:0002521	425	4	18204	48	DOCK2,SYK,PTPRC,PREX1
2.546e-02	-3.67	cell-substrate junction	cellular component	GO:0030055	437	4	19108	49	SLC9A1,PTPRC,HCK,DAB2
2.551e-02	-3.67	regulation of calcium-mediated signaling	biological process	GO:0050848	94	2	18204	48	SLC9A1,SYK
2.551e-02	-3.67	lipid binding	molecular function	GO:0008289	861	6	18094	48	RAPGEF6,PREX1,OSBPL8,FCHO2,HCK,SLC9A1
2.555e-02	-3.67	ORF7b (ORF7b protein)	protein interactions	1489675	252	3	19454	49	RHBDF2,SEMA4B,GALNT1
2.582e-02	-3.66	ARPC5 (actin related protein 2/3 complex subunit 5)	protein interactions	10092	99	2	19454	49	ASCC3,VMP1
2.582e-02	-3.66	LMTK2 (lemur tyrosine kinase 2)	protein interactions	22853	99	2	19454	49	PPP1R7,PTPN6
2.594e-02	-3.65	human chr9q22.2	chromosome location	human chr9q22.2	14	1	26134	49	SYK
2.595e-02	-3.65	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosis	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosis	413	4	16828	46	PTPRC,SLC9A1,SH2B3,DIAPH2
2.595e-02	-3.65	myelofibrosis	COSMIC cancer mutations	myelofibrosis	413	4	16828	46	SH2B3,DIAPH2,PTPRC,SLC9A1
2.595e-02	-3.65	response to organic substance	biological process	GO:0010033	2498	12	18204	48	DOCK8,PTPRC,SYK,PTPN6,SLC9A1,DAB2,HCK,GAB1,SH2B3,PTGIR,ACER2,ACACB
2.600e-02	-3.65	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	48	GAB1,SYK,SH2B3,HCK
2.606e-02	-3.65	regulation of Fc receptor mediated stimulatory signaling pathway	biological process	GO:0060368	10	1	18204	48	PTPRC
2.606e-02	-3.65	establishment of lymphocyte polarity	biological process	GO:0001767	10	1	18204	48	DOCK2
2.606e-02	-3.65	protein O-linked glycosylation via threonine	biological process	GO:0018243	10	1	18204	48	GALNT1
2.606e-02	-3.65	endothelial cell chemotaxis	biological process	GO:0035767	10	1	18204	48	GAB1
2.606e-02	-3.65	negative regulation of T cell mediated cytotoxicity	biological process	GO:0001915	10	1	18204	48	PTPRC
2.606e-02	-3.65	negative regulation of mast cell activation	biological process	GO:0033004	10	1	18204	48	PTPN6
2.606e-02	-3.65	protein O-linked glycosylation via serine	biological process	GO:0018242	10	1	18204	48	GALNT1
2.606e-02	-3.65	negative regulation of T cell differentiation in thymus	biological process	GO:0033085	10	1	18204	48	TMEM131L
2.615e-02	-3.64	6-hairpin_glycosidase_sf	interpro domains	IPR008928	10	1	18521	49	PHKB
2.615e-02	-3.64	Amino_oxidase	interpro domains	IPR002937	10	1	18521	49	SMOX
2.615e-02	-3.64	Biotin_lipoyl	interpro domains	IPR000089	10	1	18521	49	ACACB
2.615e-02	-3.64	TPR_2	interpro domains	IPR013105	10	1	18521	49	TMTC1
2.615e-02	-3.64	HAT	interpro domains	IPR003107	10	1	18521	49	TMTC1
2.615e-02	-3.64	Plexin	interpro domains	IPR031148	10	1	18521	49	PLXND1
2.619e-02	-3.64	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	49	SYK,HCK
2.619e-02	-3.64	response to xenobiotic stimulus	biological process	GO:0009410	429	4	18204	48	VAV3,SMOX,ACACB,ACER2
2.622e-02	-3.64	GDP phosphatase activity	molecular function	GO:0004382	10	1	18094	48	ENTPD1
2.622e-02	-3.64	prostaglandin receptor activity	molecular function	GO:0004955	10	1	18094	48	PTGIR
2.622e-02	-3.64	aromatic amino acid transmembrane transporter activity	molecular function	GO:0015173	10	1	18094	48	SLC16A10
2.622e-02	-3.64	AP-2 adaptor complex binding	molecular function	GO:0035612	10	1	18094	48	BMP2K
2.630e-02	-3.64	stomach	COSMIC cancer mutations	stomach	15550	46	16828	46	ENTPD1,RAPGEF6,PPP1R7,RBM47,PLXND1,OSBPL8,STAB1,SYK,HCK,ASCC3,PTPRC,SMOX,DOCK8,FCHO2,PPFIBP2,ATP10D,NACC2,GAB1,PTPN6,TMTC1,DIAPH2,BLVRA,DISC1,ACACB,TMCC3,GRK6,SLC9A1,ATG14,SEMA4B,SH2B3,GALNT1,PTGIR,BMP2K,RHBDF2,PREX1,DOCK2,VMP1,VAV3,ACER2,MPP1,CADM4,SLC16A10,PREX2,KREMEN1,TFEB,DAB2
2.630e-02	-3.64	REPS1 (RALBP1 associated Eps domain containing 1)	protein interactions	85021	100	2	19454	49	BMP2K,DAB2
2.630e-02	-3.64	AP2S1 (adaptor related protein complex 2 subunit sigma 1)	protein interactions	1175	100	2	19454	49	BMP2K,FCHO2
2.639e-02	-3.63	UTP and CTP dephosphorylation II	BIOCYC pathways	HUMAN_PWY-7177	4	1	902	6	ENTPD1
2.639e-02	-3.63	heme degradation	BIOCYC pathways	HUMAN_PWY-5874	4	1	902	6	BLVRA
2.653e-02	-3.63	regulation of muscle adaptation	biological process	GO:0043502	96	2	18204	48	SLC9A1,ACACB
2.656e-02	-3.63	glycosaminoglycan binding	molecular function	GO:0005539	243	3	18094	48	STAB1,CEMIP,PTPRC
2.659e-02	-3.63	response to wounding	biological process	GO:0009611	431	4	18204	48	VAV3,ENTPD1,PTPN6,SYK
2.666e-02	-3.62	Amino_oxidase	pfam domains	PF01593	10	1	17795	48	SMOX
2.666e-02	-3.62	TPR_2	pfam domains	PF07719	10	1	17795	48	TMTC1
2.671e-02	-3.62	positive regulation of cellular component organization	biological process	GO:0051130	1122	7	18204	48	DOCK2,PLXND1,DAB2,HCK,DISC1,PTPRC,SYK
2.678e-02	-3.62	GJD3 (gap junction protein delta 3)	protein interactions	125111	452	4	19454	49	GAB1,OSBPL8,VMP1,SLC9A1
2.679e-02	-3.62	DPP9 (dipeptidyl peptidase 9)	protein interactions	91039	101	2	19454	49	SYK,CADM4
2.679e-02	-3.62	DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1)	protein interactions	1780	101	2	19454	49	DISC1,CADM4
2.690e-02	-3.62	Protein tyrosine phosphatase superfamily	gene3d domains	3.90.190.10	88	2	14470	42	PTPRC,PTPN6
2.694e-02	-3.61	regulation of catabolic process	biological process	GO:0009894	1124	7	18204	48	ATG14,DISC1,TFEB,ACACB,ACER2,DAB2,RBM47
2.701e-02	-3.61	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	46	PREX2
2.701e-02	-3.61	chiasm	COSMIC cancer mutations	chiasm	10	1	16828	46	NACC2
2.705e-02	-3.61	SM22CALPONIN	prints domains	PR00888	11	1	5227	13	VAV3
2.727e-02	-3.60	regulation of leukocyte mediated immunity	biological process	GO:0002703	247	3	18204	48	PTPN6,SYK,PTPRC
2.728e-02	-3.60	GRAP2 (GRB2 related adaptor protein 2)	protein interactions	9402	102	2	19454	49	GAB1,SYK
2.735e-02	-3.60	hydrolase activity, hydrolyzing O-glycosyl compounds	molecular function	GO:0004553	97	2	18094	48	CEMIP,ACER2
2.737e-02	-3.60	Fcho2 (FCH domain only 2)	protein interactions	218503	11	1	19454	49	DAB2
2.737e-02	-3.60	CCDC141 (coiled-coil domain containing 141)	protein interactions	285025	11	1	19454	49	DISC1
2.737e-02	-3.60	RUBCNL (rubicon like autophagy enhancer)	protein interactions	80183	11	1	19454	49	GRK6
2.737e-02	-3.60	TESC (tescalcin)	protein interactions	54997	11	1	19454	49	SLC9A1
2.737e-02	-3.60	EEIG2 (EEIG family member 2)	protein interactions	284611	11	1	19454	49	MPP1
2.737e-02	-3.60	LAT2 (linker for activation of T cells family member 2)	protein interactions	7462	11	1	19454	49	GAB1
2.737e-02	-3.60	RGS1 (regulator of G protein signaling 1)	protein interactions	5996	11	1	19454	49	ACACB
2.737e-02	-3.60	LAX1 (lymphocyte transmembrane adaptor 1)	protein interactions	54900	11	1	19454	49	SYK
2.737e-02	-3.60	catabolic process	biological process	GO:0009056	1936	10	18204	48	TFEB,BLVRA,DISC1,ATG14,CEMIP,VMP1,SMOX,ENTPD1,ASCC3,ACER2
2.738e-02	-3.60	blood vessel morphogenesis	biological process	GO:0048514	435	4	18204	48	SYK,GAB1,VAV3,PLXND1
2.753e-02	-3.59	large_intestine-colon-adenoma	COSMIC cancer mutations	large_intestine-colon-adenoma	627	5	16828	46	PREX1,TMTC1,SYK,STAB1,HCK
2.767e-02	-3.59	Sodium/Proton exchangers	REACTOME pathways	R-HSA-425986	9	1	10285	32	SLC9A1
2.767e-02	-3.59	Formation of annular gap junctions	REACTOME pathways	R-HSA-196025	9	1	10285	32	DAB2
2.767e-02	-3.59	ChREBP activates metabolic gene expression	REACTOME pathways	R-HSA-163765	9	1	10285	32	ACACB
2.767e-02	-3.59	Prostanoid ligand receptors	REACTOME pathways	R-HSA-391908	9	1	10285	32	PTGIR
2.773e-02	-3.59	BEN	prosite domains	PS51457	9	1	12186	38	NACC2
2.774e-02	-3.58	NUP155 (nucleoporin 155)	protein interactions	9631	457	4	19454	49	OSBPL8,VMP1,DAB2,TMCC3
2.777e-02	-3.58	human chr9p24.3	chromosome location	human chr9p24.3	15	1	26134	49	DOCK8
2.777e-02	-3.58	human chr12q21.2	chromosome location	human chr12q21.2	15	1	26134	49	OSBPL8
2.777e-02	-3.58	human chr17q23.1	chromosome location	human chr17q23.1	15	1	26134	49	VMP1
2.788e-02	-3.58	Fc epsilon RI signaling pathway	KEGG pathways	hsa04664	67	2	7161	28	SYK,VAV3
2.788e-02	-3.58	Fc epsilon RI signaling pathway	KEGG pathways	ko04664	67	2	7161	28	VAV3,SYK
2.797e-02	-3.58	negative regulation of signal transduction	biological process	GO:0009968	1393	8	18204	48	PTGIR,DAB2,CADM4,SH2B3,KREMEN1,TMEM131L,PTPRC,PTPN6
2.808e-02	-3.57	negative regulation of leukocyte proliferation	biological process	GO:0070664	99	2	18204	48	PTPN6,TMEM131L
2.808e-02	-3.57	negative regulation of cytokine-mediated signaling pathway	biological process	GO:0001960	99	2	18204	48	PTPRC,SH2B3
2.812e-02	-3.57	TYR_PHOSPHATASE_2	prosite domains	PS50056	84	2	12186	38	PTPRC,PTPN6
2.828e-02	-3.57	ARHGAP18 (Rho GTPase activating protein 18)	protein interactions	93663	104	2	19454	49	PREX2,BMP2K
2.863e-02	-3.55	positive regulation of steroid hormone secretion	biological process	GO:2000833	11	1	18204	48	DAB2
2.863e-02	-3.55	pigment catabolic process	biological process	GO:0046149	11	1	18204	48	BLVRA
2.863e-02	-3.55	cellular response to epinephrine stimulus	biological process	GO:0071872	11	1	18204	48	SLC9A1
2.863e-02	-3.55	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	48	SH2B3
2.863e-02	-3.55	positive regulation of isotype switching to IgG isotypes	biological process	GO:0048304	11	1	18204	48	PTPRC
2.863e-02	-3.55	heme catabolic process	biological process	GO:0042167	11	1	18204	48	BLVRA
2.863e-02	-3.55	GDP metabolic process	biological process	GO:0046710	11	1	18204	48	MPP1
2.863e-02	-3.55	collagen-activated tyrosine kinase receptor signaling pathway	biological process	GO:0038063	11	1	18204	48	SYK
2.863e-02	-3.55	pinocytosis	biological process	GO:0006907	11	1	18204	48	DOCK2
2.863e-02	-3.55	negative regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002924	11	1	18204	48	PTPN6
2.863e-02	-3.55	pyramidal neuron development	biological process	GO:0021860	11	1	18204	48	DISC1
2.866e-02	-3.55	-	gene3d domains	6.10.140.1330	10	1	14470	42	SLC9A1
2.866e-02	-3.55	-	gene3d domains	3.30.70.3490	10	1	14470	42	OSBPL8
2.866e-02	-3.55	Rhomboid-like	gene3d domains	1.20.1540.10	10	1	14470	42	RHBDF2
2.873e-02	-3.55	SM22_calponin	interpro domains	IPR003096	11	1	18521	49	VAV3
2.873e-02	-3.55	Single_hybrid_motif	interpro domains	IPR011053	11	1	18521	49	ACACB
2.873e-02	-3.55	GBD/FH3_dom	interpro domains	IPR014768	11	1	18521	49	DIAPH2
2.873e-02	-3.55	Cation/H_exchanger_CPA1	interpro domains	IPR018422	11	1	18521	49	SLC9A1
2.879e-02	-3.55	PFKP (phosphofructokinase, platelet)	protein interactions	5214	264	3	19454	49	PTPN6,GAB1,GRK6
2.880e-02	-3.55	T cell receptor binding	molecular function	GO:0042608	11	1	18094	48	DOCK2
2.880e-02	-3.55	clathrin heavy chain binding	molecular function	GO:0032050	11	1	18094	48	CEMIP
2.880e-02	-3.55	prostanoid receptor activity	molecular function	GO:0004954	11	1	18094	48	PTGIR
2.892e-02	-3.54	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	5	PTGIR
2.893e-02	-3.54	protein tyrosine phosphatase activity	molecular function	GO:0004725	100	2	18094	48	PTPN6,PTPRC
2.907e-02	-3.54	OSBPL8 (oxysterol binding protein like 8)	protein interactions	114882	265	3	19454	49	PTGIR,SYK,DISC1
2.910e-02	-3.54	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	9	16828	46	GAB1,PTPN6,PTPRC,STAB1,SMOX,PREX2,SEMA4B,PPFIBP2,VAV3
2.910e-02	-3.54	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	9	16828	46	PTPRC,PTPN6,GAB1,VAV3,PPFIBP2,SEMA4B,SMOX,PREX2,STAB1
2.911e-02	-3.54	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	4	19454	49	MPP1,DAB2,SLC9A1,GAB1
2.914e-02	-3.54	protein O-linked glycosylation	biological process	GO:0006493	101	2	18204	48	TMTC1,GALNT1
2.933e-02	-3.53	Prot-tyrosine_phosphatase-like	interpro domains	IPR029021	101	2	18521	49	PTPRC,PTPN6
2.941e-02	-3.53	molecular adaptor activity	molecular function	GO:0060090	1138	7	18094	48	SLC9A1,SH2B3,DISC1,RBM47,DAB2,ATG14,GAB1
2.943e-02	-3.53	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	2	16828	46	DIAPH2,VAV3
2.951e-02	-3.52	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	46	HCK,BMP2K,SYK,GRK6
2.951e-02	-3.52	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	46	BMP2K,HCK,SYK,GRK6
2.951e-02	-3.52	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	49	DIAPH2,FCHO2,RAPGEF6,DOCK8
2.952e-02	-3.52	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	gene3d domains	1.10.10.10	232	3	14470	42	ASCC3,PREX2,PREX1
2.967e-02	-3.52	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	46	PREX2
2.967e-02	-3.52	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	46	PREX2
2.967e-02	-3.52	regulation of interleukin-8 production	biological process	GO:0032677	102	2	18204	48	SYK,PTPRC
2.980e-02	-3.51	APLP2 (amyloid beta precursor like protein 2)	protein interactions	334	107	2	19454	49	DAB2,DISC1
2.982e-02	-3.51	TENM4 (teneurin transmembrane protein 4)	protein interactions	26011	12	1	19454	49	DOCK2
2.982e-02	-3.51	ANO5 (anoctamin 5)	protein interactions	203859	12	1	19454	49	PTGIR
2.982e-02	-3.51	RTL6 (retrotransposon Gag like 6)	protein interactions	84247	12	1	19454	49	PPFIBP2
2.982e-02	-3.51	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	49	PTPN6
2.982e-02	-3.51	NUDT4 (nudix hydrolase 4)	protein interactions	11163	12	1	19454	49	DISC1
2.982e-02	-3.51	IGKV1-5 (immunoglobulin kappa variable 1-5)	protein interactions	28299	12	1	19454	49	CEMIP
2.982e-02	-3.51	ZNF584 (zinc finger protein 584)	protein interactions	201514	12	1	19454	49	MPP1
2.982e-02	-3.51	CIART (circadian associated repressor of transcription)	protein interactions	148523	12	1	19454	49	BLVRA
2.982e-02	-3.51	SIRPB1 (signal regulatory protein beta 1)	protein interactions	10326	12	1	19454	49	SYK
2.982e-02	-3.51	LTB4R (leukotriene B4 receptor)	protein interactions	1241	12	1	19454	49	GRK6
2.982e-02	-3.51	TM7SF2 (transmembrane 7 superfamily member 2)	protein interactions	7108	12	1	19454	49	DISC1
2.982e-02	-3.51	SSTR2 (somatostatin receptor 2)	protein interactions	6752	12	1	19454	49	PTPN6
2.982e-02	-3.51	C8orf76 (chromosome 8 open reading frame 76)	protein interactions	84933	12	1	19454	49	DISC1
2.982e-02	-3.51	PNMT (phenylethanolamine N-methyltransferase)	protein interactions	5409	12	1	19454	49	HCK
2.987e-02	-3.51	Class I PI3K signaling events	Pathway Interaction DB	pi3kcipathway	41	2	2226	15	PREX1,HCK
2.988e-02	-3.51	positive regulation of growth	biological process	GO:0045927	256	3	18204	48	ACACB,SLC9A1,DISC1
2.988e-02	-3.51	protein complex oligomerization	biological process	GO:0051259	256	3	18204	48	SLC9A1,NACC2,ACACB
2.997e-02	-3.51	TyrKc	smart domains	SM00219	80	2	9717	33	HCK,SYK
3.000e-02	-3.51	modified amino acid binding	molecular function	GO:0072341	102	2	18094	48	OSBPL8,FCHO2
3.017e-02	-3.50	Drf_FH3	smart domains	SM01139	9	1	9717	33	DIAPH2
3.017e-02	-3.50	Drf_GBD	smart domains	SM01140	9	1	9717	33	DIAPH2
3.017e-02	-3.50	BEN	smart domains	SM01025	9	1	9717	33	NACC2
3.024e-02	-3.50	XPO1 (exportin 1)	protein interactions	7514	1479	8	19454	49	FCHO2,GRK6,BMP2K,RAPGEF6,ASCC3,DAB2,DOCK8,TFEB
3.028e-02	-3.50	regulation of innate immune response	biological process	GO:0045088	449	4	18204	48	HCK,PTPN6,SYK,RBM47
3.028e-02	-3.50	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	48	PREX1,PLXND1,KREMEN1,DAB2,DISC1
3.040e-02	-3.49	Ig_E-set	interpro domains	IPR014756	103	2	18521	49	ASCC3,PLXND1
3.041e-02	-3.49	G alpha (12/13) signalling events	REACTOME pathways	R-HSA-416482	88	2	10285	32	VAV3,PREX1
3.069e-02	-3.48	MET receptor recycling	REACTOME pathways	R-HSA-8875656	10	1	10285	32	GAB1
3.069e-02	-3.48	Gap junction degradation	REACTOME pathways	R-HSA-190873	10	1	10285	32	DAB2
3.069e-02	-3.48	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	32	GAB1
3.070e-02	-3.48	oesophagus	COSMIC cancer mutations	oesophagus	14970	45	16828	46	SMOX,FCHO2,DOCK8,PPFIBP2,HCK,PTPRC,ASCC3,BLVRA,DIAPH2,DISC1,ATP10D,NACC2,PTPN6,GAB1,TMTC1,ENTPD1,STAB1,SYK,RAPGEF6,PPP1R7,RBM47,PLXND1,OSBPL8,VMP1,DOCK2,VAV3,PTGIR,RHBDF2,PREX1,PREX2,TFEB,KREMEN1,DAB2,MPP1,ACER2,CADM4,SLC16A10,TMCC3,ACACB,SEMA4B,SH2B3,GALNT1,SLC9A1,GRK6,ATG14
3.071e-02	-3.48	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	35	16828	46	PTPRC,PREX1,ASCC3,RHBDF2,BMP2K,PPFIBP2,VAV3,VMP1,DOCK8,DOCK2,SMOX,TMTC1,SLC16A10,GAB1,CADM4,PTPN6,NACC2,ACER2,ATP10D,DAB2,KREMEN1,PREX2,DIAPH2,BLVRA,ACACB,TMCC3,ENTPD1,OSBPL8,ATG14,GRK6,PLXND1,SYK,SH2B3,STAB1,SEMA4B
3.071e-02	-3.48	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	35	16828	46	ACACB,ENTPD1,TMCC3,PLXND1,GRK6,ATG14,OSBPL8,SEMA4B,SH2B3,STAB1,SYK,BMP2K,RHBDF2,PREX1,ASCC3,PTPRC,SMOX,DOCK2,DOCK8,VMP1,VAV3,PPFIBP2,ATP10D,ACER2,NACC2,GAB1,PTPN6,CADM4,SLC16A10,TMTC1,DIAPH2,BLVRA,PREX2,KREMEN1,DAB2
3.075e-02	-3.48	epithelial cell migration	biological process	GO:0010631	104	2	18204	48	GAB1,PLXND1
3.075e-02	-3.48	regulation of dephosphorylation	biological process	GO:0035303	104	2	18204	48	PPP1R7,PTPRC
3.075e-02	-3.48	protein polymerization	biological process	GO:0051258	104	2	18204	48	PREX1,DIAPH2
3.075e-02	-3.48	negative regulation of response to cytokine stimulus	biological process	GO:0060761	104	2	18204	48	PTPRC,SH2B3
3.075e-02	-3.48	positive regulation of ubiquitin-dependent protein catabolic process	biological process	GO:2000060	104	2	18204	48	DAB2,DISC1
3.076e-02	-3.48	BIOTINYL_LIPOYL	prosite domains	PS50968	10	1	12186	38	ACACB
3.079e-02	-3.48	regulation of MAPK cascade	biological process	GO:0043408	669	5	18204	48	DAB2,PTPN6,SH2B3,SYK,PTPRC
3.083e-02	-3.48	RPL10L (ribosomal protein L10 like)	protein interactions	140801	109	2	19454	49	PTPN6,CEMIP
3.083e-02	-3.48	TMEM9B (TMEM9 domain family member B)	protein interactions	56674	109	2	19454	49	OSBPL8,RHBDF2
3.091e-02	-3.48	carbohydrate derivative binding	molecular function	GO:0097367	2251	11	18094	48	ASCC3,BMP2K,GRK6,ENTPD1,SYK,ATP10D,ACACB,CEMIP,PTPRC,HCK,STAB1
3.100e-02	-3.47	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	7	19454	49	PPFIBP2,TMCC3,DISC1,RAPGEF6,GAB1,TFEB,OSBPL8
3.120e-02	-3.47	negative regulation of vascular endothelial growth factor receptor signaling pathway	biological process	GO:0030948	12	1	18204	48	CADM4
3.120e-02	-3.47	regulation of immature T cell proliferation in thymus	biological process	GO:0033084	12	1	18204	48	TMEM131L
3.120e-02	-3.47	regulation of immature T cell proliferation	biological process	GO:0033083	12	1	18204	48	TMEM131L
3.120e-02	-3.47	cytidine to uridine editing	biological process	GO:0016554	12	1	18204	48	RBM47
3.120e-02	-3.47	thyroid hormone transport	biological process	GO:0070327	12	1	18204	48	SLC16A10
3.120e-02	-3.47	cellular response to antibiotic	biological process	GO:0071236	12	1	18204	48	SLC9A1
3.120e-02	-3.47	regulation of protein glycosylation	biological process	GO:0060049	12	1	18204	48	ACER2
3.120e-02	-3.47	aromatic amino acid transport	biological process	GO:0015801	12	1	18204	48	SLC16A10
3.120e-02	-3.47	DNA alkylation repair	biological process	GO:0006307	12	1	18204	48	ASCC3
3.120e-02	-3.47	serotonin transport	biological process	GO:0006837	12	1	18204	48	SYK
3.120e-02	-3.47	regulation of chemokine-mediated signaling pathway	biological process	GO:0070099	12	1	18204	48	SH2B3
3.120e-02	-3.47	regulation of inflammatory response to wounding	biological process	GO:0106014	12	1	18204	48	PTPN6
3.120e-02	-3.47	negative regulation of cell adhesion mediated by integrin	biological process	GO:0033629	12	1	18204	48	ACER2
3.120e-02	-3.47	cellular response to electrical stimulus	biological process	GO:0071257	12	1	18204	48	SLC9A1
3.130e-02	-3.46	OSBP_sf	interpro domains	IPR037239	12	1	18521	49	OSBPL8
3.130e-02	-3.46	Oxysterol-bd_CS	interpro domains	IPR018494	12	1	18521	49	OSBPL8
3.130e-02	-3.46	PreATP-grasp_dom_sf	interpro domains	IPR016185	12	1	18521	49	ACACB
3.130e-02	-3.46	Oxysterol-bd	interpro domains	IPR000648	12	1	18521	49	OSBPL8
3.138e-02	-3.46	semaphorin receptor activity	molecular function	GO:0017154	12	1	18094	48	PLXND1
3.138e-02	-3.46	non-membrane spanning protein tyrosine phosphatase activity	molecular function	GO:0004726	12	1	18094	48	PTPN6
3.138e-02	-3.46	phosphatidylinositol 3-kinase regulator activity	molecular function	GO:0035014	12	1	18094	48	ATG14
3.139e-02	-3.46	positive regulation of immune effector process	biological process	GO:0002699	261	3	18204	48	SYK,PTPRC,PTPN6
3.150e-02	-3.46	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	46	BMP2K,HCK,SYK,GRK6
3.157e-02	-3.46	regulation of cellular catabolic process	biological process	GO:0031329	455	4	18204	48	TFEB,ATG14,ACER2,ACACB
3.160e-02	-3.45	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	11	16828	46	HCK,BMP2K,PTPRC,STAB1,PREX2,DAB2,SYK,TFEB,GALNT1,GRK6,PLXND1
3.164e-02	-3.45	phosphatase regulator activity	molecular function	GO:0019208	105	2	18094	48	PPP1R7,BMP2K
3.165e-02	-3.45	ACTBL2 (actin beta like 2)	protein interactions	345651	274	3	19454	49	OSBPL8,DISC1,VMP1
3.165e-02	-3.45	PANX1 (pannexin 1)	protein interactions	24145	274	3	19454	49	SLC9A1,VMP1,OSBPL8
3.190e-02	-3.45	Oxysterol_BP	pfam domains	PF01237	12	1	17795	48	OSBPL8
3.223e-02	-3.43	positive regulation of cell development	biological process	GO:0010720	458	4	18204	48	PLXND1,DISC1,SYK,PTPRC
3.224e-02	-3.43	RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit)	protein interactions	5929	276	3	19454	49	ACACB,DISC1,PHKB
3.226e-02	-3.43	CHP2 (calcineurin like EF-hand protein 2)	protein interactions	63928	13	1	19454	49	SLC9A1
3.226e-02	-3.43	RPC11 (DNA-directed RNA polymerase III core subunit RPC11)	protein interactions	851615	13	1	19454	49	PPFIBP2
3.226e-02	-3.43	OTOA (otoancorin)	protein interactions	146183	13	1	19454	49	GALNT1
3.226e-02	-3.43	NFAM1 (NFAT activating protein with ITAM motif 1)	protein interactions	150372	13	1	19454	49	SYK
3.226e-02	-3.43	CEACAM16 (CEA cell adhesion molecule 16, tectorial membrane component)	protein interactions	388551	13	1	19454	49	MPP1
3.226e-02	-3.43	C1orf74 (chromosome 1 open reading frame 74)	protein interactions	148304	13	1	19454	49	HCK
3.226e-02	-3.43	Kif20b (kinesin family member 20B)	protein interactions	240641	13	1	19454	49	DIAPH2
3.226e-02	-3.43	CRYGC (crystallin gamma C)	protein interactions	1420	13	1	19454	49	DISC1
3.226e-02	-3.43	PPP1R2B (PPP1R2 family member B)	protein interactions	153743	13	1	19454	49	BMP2K
3.232e-02	-3.43	bone-sacrum-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-sacrum-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	12	1	16828	46	STAB1
3.232e-02	-3.43	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	46	PREX2
3.232e-02	-3.43	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	12	1	16828	46	NACC2
3.234e-02	-3.43	Platelet homeostasis	REACTOME pathways	R-HSA-418346	91	2	10285	32	PTGIR,PTPN6
3.240e-02	-3.43	T cell receptor signaling pathway	biological process	GO:0050852	107	2	18204	48	PTPN6,PTPRC
3.240e-02	-3.43	epithelium migration	biological process	GO:0090132	107	2	18204	48	PLXND1,GAB1
3.241e-02	-3.43	GLG1 (golgi glycoprotein 1)	protein interactions	2734	112	2	19454	49	SYK,OSBPL8
3.241e-02	-3.43	C10orf88 (chromosome 10 open reading frame 88)	protein interactions	80007	112	2	19454	49	RBM47,BMP2K
3.241e-02	-3.43	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	49	OSBPL8,PTGIR
3.246e-02	-3.43	immune system process	biological process	GO:0002376	1991	10	18204	48	HCK,PREX1,DOCK2,SH2B3,VAV3,DOCK8,TFEB,SYK,PTPRC,PTPN6
3.262e-02	-3.42	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	48	DAB2,KREMEN1,TMEM131L
3.281e-02	-3.42	endoplasmic reticulum membrane	cellular component	GO:0005789	1204	7	19108	49	ATG14,OSBPL8,RHBDF2,GALNT1,ATP10D,TMCC3,VMP1
3.284e-02	-3.42	early phagosome	cellular component	GO:0032009	13	1	19108	49	SYK
3.284e-02	-3.42	semaphorin receptor complex	cellular component	GO:0002116	13	1	19108	49	PLXND1
3.289e-02	-3.41	response to bacterium	biological process	GO:0009617	681	5	18204	48	STAB1,SYK,TFEB,HCK,PTGIR
3.289e-02	-3.41	fatty acid biosynthesis initiation	BIOCYC pathways	HUMAN_PWY-5966-1	5	1	902	6	ACACB
3.289e-02	-3.41	mucin core 1 and core 2 O-glycosylation	BIOCYC pathways	META_PWY-7433	5	1	902	6	GALNT1
3.294e-02	-3.41	LAT (linker for activation of T cells)	protein interactions	27040	113	2	19454	49	PTPN6,SYK
3.319e-02	-3.41	SH3_1	pfam domains	PF00018	106	2	17795	48	HCK,MPP1
3.323e-02	-3.40	human chr4p12	chromosome location	human chr4p12	18	1	26134	49	ATP10D
3.323e-02	-3.40	human chr4q21.21	chromosome location	human chr4q21.21	18	1	26134	49	BMP2K
3.325e-02	-3.40	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	48	PLXND1,PREX1,KREMEN1,DAB2,DISC1
3.325e-02	-3.40	MTDH (metadherin)	protein interactions	92140	484	4	19454	49	RHBDF2,SYK,DOCK2,DISC1
3.332e-02	-3.40	phosphatidylinositol bisphosphate binding	molecular function	GO:1902936	108	2	18094	48	FCHO2,SLC9A1
3.346e-02	-3.40	endoplasmic reticulum subcompartment	cellular component	GO:0098827	1209	7	19108	49	GALNT1,RHBDF2,OSBPL8,ATG14,VMP1,TMCC3,ATP10D
3.346e-02	-3.40	HAT	smart domains	SM00386	10	1	9717	33	TMTC1
3.350e-02	-3.40	brainstem	COSMIC cancer mutations	brainstem	3102	14	16828	46	DOCK2,VAV3,PPFIBP2,PREX1,ASCC3,KREMEN1,GALNT1,DIAPH2,PREX2,RBM47,TMTC1,GAB1,PTPN6,NACC2
3.351e-02	-3.40	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	2	18204	48	PTPRC,SYK
3.353e-02	-3.40	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	27	16828	46	PPFIBP2,VAV3,DOCK8,DOCK2,SMOX,PTPRC,ASCC3,PREX1,HCK,RHBDF2,DAB2,KREMEN1,PREX2,TMTC1,GAB1,PTPN6,NACC2,MPP1,ATP10D,TMCC3,ENTPD1,ACACB,STAB1,SEMA4B,PLXND1,GRK6,RAPGEF6
3.362e-02	-3.39	Signaling by the B Cell Receptor (BCR)	REACTOME pathways	R-HSA-983705	229	3	10285	32	GAB1,SYK,PTPN6
3.371e-02	-3.39	Signaling by FGFR4 in disease	REACTOME pathways	R-HSA-5655291	11	1	10285	32	GAB1
3.371e-02	-3.39	MET activates RAP1 and RAC1	REACTOME pathways	R-HSA-8875555	11	1	10285	32	GAB1
3.371e-02	-3.39	Biotin transport and metabolism	REACTOME pathways	R-HSA-196780	11	1	10285	32	ACACB
3.375e-02	-3.39	porphyrin-containing compound catabolic process	biological process	GO:0006787	13	1	18204	48	BLVRA
3.375e-02	-3.39	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	48	SH2B3
3.375e-02	-3.39	protein localization to nuclear envelope	biological process	GO:0090435	13	1	18204	48	OSBPL8
3.375e-02	-3.39	type II interferon-mediated signaling pathway	biological process	GO:0060333	13	1	18204	48	HCK
3.375e-02	-3.39	tetrapyrrole catabolic process	biological process	GO:0033015	13	1	18204	48	BLVRA
3.375e-02	-3.39	negative regulation of platelet-derived growth factor receptor signaling pathway	biological process	GO:0010642	13	1	18204	48	PTGIR
3.375e-02	-3.39	modulation of process of another organism	biological process	GO:0035821	13	1	18204	48	SYK
3.375e-02	-3.39	cellular response to cold	biological process	GO:0070417	13	1	18204	48	SLC9A1
3.379e-02	-3.39	GBD_FH3	prosite domains	PS51232	11	1	12186	38	DIAPH2
3.386e-02	-3.39	ATP-grasp	interpro domains	IPR011761	13	1	18521	49	ACACB
3.388e-02	-3.38	regulation of actin filament organization	biological process	GO:0110053	269	3	18204	48	SLC9A1,HCK,PREX1
3.395e-02	-3.38	vascular endothelial growth factor receptor binding	molecular function	GO:0005172	13	1	18094	48	CADM4
3.401e-02	-3.38	PPARD (peroxisome proliferator activated receptor delta)	protein interactions	5467	115	2	19454	49	NACC2,ACACB
3.403e-02	-3.38	regulation of monoatomic ion transport	biological process	GO:0043269	466	4	18204	48	CEMIP,PTPN6,VMP1,SLC9A1
3.404e-02	-3.38	PGK1 (phosphoglycerate kinase 1)	protein interactions	5230	282	3	19454	49	DISC1,ATG14,DOCK8
3.411e-02	-3.38	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	22	16828	46	GAB1,ATP10D,MPP1,ACER2,TMTC1,PLXND1,DIAPH2,BLVRA,SEMA4B,DAB2,DISC1,SYK,TFEB,GALNT1,ACACB,PREX1,PTPRC,TMCC3,SMOX,VAV3,DOCK2,FCHO2
3.411e-02	-3.38	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	22	16828	46	PTPRC,PREX1,ACACB,VAV3,FCHO2,DOCK2,TMCC3,SMOX,TMTC1,PLXND1,GAB1,MPP1,ACER2,ATP10D,DISC1,DAB2,GALNT1,TFEB,SYK,BLVRA,SEMA4B,DIAPH2
3.429e-02	-3.37	-	gene3d domains	2.40.160.120	12	1	14470	42	OSBPL8
3.429e-02	-3.37	-	gene3d domains	3.40.50.20	12	1	14470	42	ACACB
3.430e-02	-3.37	KRINGLE	prints domains	PR00018	14	1	5227	13	KREMEN1
3.434e-02	-3.37	PSPC1 (paraspeckle component 1)	protein interactions	55269	489	4	19454	49	DISC1,VAV3,ASCC3,OSBPL8
3.452e-02	-3.37	TPR_19	pfam domains	PF14559	13	1	17795	48	TMTC1
3.455e-02	-3.37	ARL5A (ADP ribosylation factor like GTPase 5A)	protein interactions	26225	116	2	19454	49	CADM4,ACACB
3.455e-02	-3.37	CD4 (CD4 molecule)	protein interactions	920	116	2	19454	49	SYK,PTPRC
3.458e-02	-3.36	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	38	HCK,SYK
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	ENTPD1,HCK
3.465e-02	-3.36	negative regulation of binding	biological process	GO:0051100	111	2	18204	48	DAB2,DISC1
3.465e-02	-3.36	positive regulation of lipid localization	biological process	GO:1905954	111	2	18204	48	DAB2,ACACB
3.470e-02	-3.36	ZNF287 (zinc finger protein 287)	protein interactions	57336	14	1	19454	49	MPP1
3.470e-02	-3.36	PHF13 (PHD finger protein 13)	protein interactions	148479	14	1	19454	49	BLVRA
3.470e-02	-3.36	TFEC (transcription factor EC)	protein interactions	22797	14	1	19454	49	TFEB
3.470e-02	-3.36	PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene))	protein interactions	5408	14	1	19454	49	GRK6
3.470e-02	-3.36	ITGAL (integrin subunit alpha L)	protein interactions	3683	14	1	19454	49	PTPRC
3.470e-02	-3.36	SPMIP4 (sperm microtubule inner protein 4)	protein interactions	136895	14	1	19454	49	GRK6
3.470e-02	-3.36	GRK1 (G protein-coupled receptor kinase 1)	protein interactions	6011	14	1	19454	49	GRK6
3.497e-02	-3.35	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	46	PREX2
3.497e-02	-3.35	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	46	PREX2
3.497e-02	-3.35	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	13	1	16828	46	NACC2
3.504e-02	-3.35	human chr14q22.3	chromosome location	human chr14q22.3	19	1	26134	49	ATG14
3.514e-02	-3.35	autophagosome	cellular component	GO:0005776	115	2	19108	49	ATG14,VMP1
3.523e-02	-3.35	MAPK1 (mitogen-activated protein kinase 1)	protein interactions	5594	493	4	19454	49	GAB1,PTPRC,BLVRA,SLC9A1
3.523e-02	-3.35	SEC62 (SEC62 homolog, preprotein translocation factor)	protein interactions	7095	493	4	19454	49	OSBPL8,TMEM131L,SLC9A1,VMP1
3.527e-02	-3.34	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	13	16828	46	ASCC3,BMP2K,HCK,ACACB,VMP1,DOCK2,SLC9A1,PLXND1,TMTC1,PTPN6,GALNT1,PREX2,DIAPH2
3.527e-02	-3.34	gallbladder	COSMIC cancer mutations	gallbladder	2821	13	16828	46	BMP2K,HCK,ACACB,ASCC3,VMP1,DOCK2,PTPN6,PLXND1,SLC9A1,TMTC1,PREX2,DIAPH2,GALNT1
3.532e-02	-3.34	phospholipid-translocating ATPase complex	cellular component	GO:1990531	14	1	19108	49	ATP10D
3.533e-02	-3.34	rib	COSMIC cancer mutations	rib	264	3	16828	46	ACACB,RHBDF2,ASCC3
3.549e-02	-3.34	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	46	GRK6,SYK,HCK,BMP2K
3.565e-02	-3.33	SLC22A9 (solute carrier family 22 member 9)	protein interactions	114571	118	2	19454	49	TMEM131L,SLC16A10
3.565e-02	-3.33	B4GALT2 (beta-1,4-galactosyltransferase 2)	protein interactions	8704	118	2	19454	49	NACC2,ASCC3
3.565e-02	-3.33	DNASE1L1 (deoxyribonuclease 1 like 1)	protein interactions	1774	118	2	19454	49	PLXND1,CEMIP
3.565e-02	-3.33	DNAAF10 (dynein axonemal assembly factor 10)	protein interactions	116143	118	2	19454	49	PPP1R7,GRK6
3.567e-02	-3.33	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	265	3	16828	46	SYK,HCK,SH2B3
3.567e-02	-3.33	OCLN (occludin)	protein interactions	100506658	495	4	19454	49	GAB1,RHBDF2,RAPGEF6,FCHO2
3.570e-02	-3.33	cytokine receptor binding	molecular function	GO:0005126	273	3	18094	48	SH2B3,SYK,CADM4
3.578e-02	-3.33	breast-carcinoma	COSMIC cancer mutations	breast-carcinoma	15030	45	16828	46	ENTPD1,RAPGEF6,PPP1R7,PLXND1,RBM47,OSBPL8,STAB1,SYK,HCK,ASCC3,PTPRC,SMOX,DOCK8,FCHO2,PPFIBP2,ATP10D,GAB1,PTPN6,TMTC1,BLVRA,DIAPH2,DISC1,ACACB,TMCC3,GRK6,SLC9A1,ATG14,SEMA4B,SH2B3,GALNT1,BMP2K,PTGIR,RHBDF2,PREX1,DOCK2,VMP1,VAV3,MPP1,ACER2,CADM4,SLC16A10,PREX2,KREMEN1,TFEB,DAB2
3.579e-02	-3.33	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	2	18204	48	PTPRC,SYK
3.579e-02	-3.33	tissue migration	biological process	GO:0090130	113	2	18204	48	GAB1,PLXND1
3.584e-02	-3.33	nuclear outer membrane-endoplasmic reticulum membrane network	cellular component	GO:0042175	1227	7	19108	49	OSBPL8,ATG14,GALNT1,RHBDF2,TMCC3,ATP10D,VMP1
3.598e-02	-3.32	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	46	BMP2K,HCK,SYK,GRK6
3.619e-02	-3.32	signaling adaptor activity	molecular function	GO:0035591	113	2	18094	48	SH2B3,GAB1
3.620e-02	-3.32	UXT (ubiquitously expressed prefoldin like chaperone)	protein interactions	8409	119	2	19454	49	PPP1R7,MPP1
3.620e-02	-3.32	MCM10 (minichromosome maintenance 10 replication initiation factor)	protein interactions	55388	119	2	19454	49	ATG14,DISC1
3.630e-02	-3.32	negative regulation of fatty acid oxidation	biological process	GO:0046322	14	1	18204	48	ACACB
3.630e-02	-3.32	pentose-phosphate shunt	biological process	GO:0006098	14	1	18204	48	ACACB
3.630e-02	-3.32	regulation of protein complex stability	biological process	GO:0061635	14	1	18204	48	ATG14
3.630e-02	-3.32	sodium ion export across plasma membrane	biological process	GO:0036376	14	1	18204	48	SLC9A1
3.630e-02	-3.32	regulation of podosome assembly	biological process	GO:0071801	14	1	18204	48	HCK
3.630e-02	-3.32	polyamine biosynthetic process	biological process	GO:0006596	14	1	18204	48	SMOX
3.630e-02	-3.32	sphingosine biosynthetic process	biological process	GO:0046512	14	1	18204	48	ACER2
3.630e-02	-3.32	positive regulation of sodium ion transmembrane transporter activity	biological process	GO:2000651	14	1	18204	48	SLC9A1
3.630e-02	-3.32	response to epinephrine	biological process	GO:0071871	14	1	18204	48	SLC9A1
3.630e-02	-3.32	sphingoid biosynthetic process	biological process	GO:0046520	14	1	18204	48	ACER2
3.635e-02	-3.31	p75 NTR receptor-mediated signalling	REACTOME pathways	R-HSA-193704	97	2	10285	32	VAV3,PREX1
3.637e-02	-3.31	regulation of cell killing	biological process	GO:0031341	114	2	18204	48	PTPRC,SYK
3.642e-02	-3.31	MHD	interpro domains	IPR028565	14	1	18521	49	FCHO2
3.642e-02	-3.31	Rhomboid-like_sf	interpro domains	IPR035952	14	1	18521	49	RHBDF2
3.642e-02	-3.31	P_typ_ATPase_c	interpro domains	IPR032630	14	1	18521	49	ATP10D
3.642e-02	-3.31	Cation/H_exchanger	interpro domains	IPR006153	14	1	18521	49	SLC9A1
3.642e-02	-3.31	P-type_ATPase_IV	interpro domains	IPR006539	14	1	18521	49	ATP10D
3.642e-02	-3.31	ATP_grasp_subdomain_1	interpro domains	IPR013815	14	1	18521	49	ACACB
3.642e-02	-3.31	Neurexin-like	interpro domains	IPR003585	14	1	18521	49	CADM4
3.642e-02	-3.31	P-type_ATPase_N	interpro domains	IPR032631	14	1	18521	49	ATP10D
3.642e-02	-3.31	Link_dom	interpro domains	IPR000538	14	1	18521	49	STAB1
3.652e-02	-3.31	RRBP1 (ribosome binding protein 1)	protein interactions	6238	290	3	19454	49	CEMIP,DISC1,RHBDF2
3.652e-02	-3.31	Toll-like receptor binding	molecular function	GO:0035325	14	1	18094	48	SYK
3.652e-02	-3.31	potassium:proton antiporter activity	molecular function	GO:0015386	14	1	18094	48	SLC9A1
3.655e-02	-3.31	vacuolar membrane	cellular component	GO:0005774	490	4	19108	49	ATG14,DAB2,TFEB,VMP1
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	SLC9A1,FCHO2,OSBPL8
3.672e-02	-3.30	PECAM1 interactions	REACTOME pathways	R-HSA-210990	12	1	10285	32	PTPN6
3.672e-02	-3.30	Hyaluronan uptake and degradation	REACTOME pathways	R-HSA-2160916	12	1	10285	32	SLC9A1
3.680e-02	-3.30	LINK_1	prosite domains	PS01241	12	1	12186	38	STAB1
3.680e-02	-3.30	OSBP	prosite domains	PS01013	12	1	12186	38	OSBPL8
3.680e-02	-3.30	establishment of localization	biological process	GO:0051234	3887	16	18204	48	SLC9A1,VMP1,SYK,PTPRC,ATP10D,OSBPL8,HCK,DAB2,DOCK2,SLC16A10,RHBDF2,VAV3,FCHO2,STAB1,ATG14,ACACB
3.685e-02	-3.30	human chr18q12.2	chromosome location	human chr18q12.2	20	1	26134	49	GALNT1
3.703e-02	-3.30	angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	angioimmunoblastic_T_cell_lymphoma	269	3	16828	46	SYK,SH2B3,HCK
3.712e-02	-3.29	PhoLip_ATPase_N	pfam domains	PF16209	14	1	17795	48	ATP10D
3.712e-02	-3.29	PhoLip_ATPase_C	pfam domains	PF16212	14	1	17795	48	ATP10D
3.712e-02	-3.29	Na_H_Exchanger	pfam domains	PF00999	14	1	17795	48	SLC9A1
3.712e-02	-3.29	Xlink	pfam domains	PF00193	14	1	17795	48	STAB1
3.714e-02	-3.29	GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4)	protein interactions	8693	15	1	19454	49	GALNT1
3.714e-02	-3.29	ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)	protein interactions	953	15	1	19454	49	ASCC3
3.714e-02	-3.29	FAM187B (family with sequence similarity 187 member B)	protein interactions	148109	15	1	19454	49	OSBPL8
3.714e-02	-3.29	AANAT (aralkylamine N-acetyltransferase)	protein interactions	15	15	1	19454	49	NACC2
3.714e-02	-3.29	PRSS22 (serine protease 22)	protein interactions	64063	15	1	19454	49	GALNT1
3.714e-02	-3.29	UCP3 (uncoupling protein 3)	protein interactions	7352	15	1	19454	49	RBM47
3.714e-02	-3.29	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	49	DISC1
3.714e-02	-3.29	SAMD3 (sterile alpha motif domain containing 3)	protein interactions	154075	15	1	19454	49	ACACB
3.715e-02	-3.29	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	24	16828	46	ACACB,ENTPD1,RBM47,GRK6,PLXND1,SEMA4B,STAB1,SYK,PTGIR,RHBDF2,HCK,PREX1,ASCC3,PTPRC,DOCK2,DOCK8,FCHO2,PPFIBP2,CADM4,PTPN6,NACC2,DIAPH2,PREX2,KREMEN1
3.740e-02	-3.29	protein kinase binding	molecular function	GO:0019901	701	5	18094	48	PTPRC,CADM4,SYK,PTPN6,SH2B3
3.747e-02	-3.28	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	46	BMP2K,HCK,SYK,GRK6
3.754e-02	-3.28	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	8	16828	46	ACACB,RAPGEF6,PTPRC,PREX2,SH2B3,STAB1,DOCK2,PPFIBP2
3.754e-02	-3.28	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	8	16828	46	PREX2,STAB1,SH2B3,DOCK2,PPFIBP2,RAPGEF6,ACACB,PTPRC
3.754e-02	-3.28	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	GO:0043280	116	2	18204	48	SYK,ACER2
3.754e-02	-3.28	regulation of alpha-beta T cell activation	biological process	GO:0046634	116	2	18204	48	SYK,PTPRC
3.761e-02	-3.28	soft_tissue-fibrous_tissue_and_uncertain_origin-solitary_fibrous_tumour-malignant	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-solitary_fibrous_tumour-malignant	14	1	16828	46	ASCC3
3.768e-02	-3.28	ATP binding	molecular function	GO:0005524	1467	8	18094	48	ACACB,HCK,ASCC3,SYK,ATP10D,BMP2K,GRK6,ENTPD1
3.773e-02	-3.28	Cargo recognition for clathrin-mediated endocytosis	REACTOME pathways	R-HSA-8856825	99	2	10285	32	FCHO2,DAB2
3.776e-02	-3.28	Prot_kinase_dom	interpro domains	IPR000719	480	4	18521	49	GRK6,SYK,BMP2K,HCK
3.779e-02	-3.28	IGF2R (insulin like growth factor 2 receptor)	protein interactions	3482	294	3	19454	49	SLC9A1,DISC1,RHBDF2
3.787e-02	-3.27	biological regulation	biological process	GO:0065007	12501	39	18204	48	DAB2,HCK,GRK6,RHBDF2,VMP1,OSBPL8,PPP1R7,TMEM131L,PREX1,ACER2,MPP1,SH2B3,BMP2K,ATG14,STAB1,GAB1,TFEB,SEMA4B,DOCK2,SLC16A10,RBM47,PREX2,SLC9A1,NACC2,PTPN6,PTPRC,SYK,DISC1,ATP10D,DOCK8,ACACB,PLXND1,PTGIR,ENTPD1,CADM4,VAV3,KREMEN1,CEMIP,RAPGEF6
3.788e-02	-3.27	HLA-DRB1 (major histocompatibility complex, class II, DR beta 1)	protein interactions	3123	122	2	19454	49	CADM4,TMEM131L
3.797e-02	-3.27	actin filament	cellular component	GO:0005884	120	2	19108	49	DIAPH2,HCK
3.811e-02	-3.27	ACTR2 (actin related protein 2)	protein interactions	10097	295	3	19454	49	VMP1,DAB2,BLVRA
3.825e-02	-3.26	acinar_carcinoma	COSMIC cancer mutations	acinar_carcinoma	1978	10	16828	46	ENTPD1,SMOX,DOCK2,NACC2,RHBDF2,HCK,PLXND1,PPP1R7,TMTC1,ASCC3
3.825e-02	-3.26	pancreas-carcinoma-acinar_carcinoma	COSMIC cancer mutations	pancreas-carcinoma-acinar_carcinoma	1978	10	16828	46	NACC2,RHBDF2,HCK,TMTC1,ASCC3,PPP1R7,PLXND1,ENTPD1,SMOX,DOCK2
3.844e-02	-3.26	PTK2 (protein tyrosine kinase 2)	protein interactions	5747	296	3	19454	49	PTPN6,HCK,SYK
3.854e-02	-3.26	export from cell	biological process	GO:0140352	485	4	18204	48	SLC16A10,SYK,HCK,SLC9A1
3.859e-02	-3.25	endometrium-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-endometrioid_carcinoma	15680	46	16828	46	STAB1,SYK,RAPGEF6,PPP1R7,PLXND1,RBM47,OSBPL8,ENTPD1,BLVRA,DIAPH2,DISC1,ATP10D,GAB1,NACC2,PTPN6,TMTC1,SMOX,FCHO2,DOCK8,PPFIBP2,HCK,PTPRC,ASCC3,SEMA4B,SH2B3,GALNT1,GRK6,SLC9A1,ATG14,TMCC3,ACACB,PREX2,TFEB,KREMEN1,DAB2,MPP1,ACER2,CADM4,SLC16A10,VMP1,DOCK2,VAV3,BMP2K,PTGIR,RHBDF2,PREX1
3.862e-02	-3.25	lymph_node	COSMIC cancer mutations	lymph_node	1703	9	16828	46	ASCC3,GRK6,HCK,SYK,KREMEN1,DOCK2,VMP1,GALNT1,SEMA4B
3.880e-02	-3.25	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	2	16828	46	PREX2,RBM47
3.880e-02	-3.25	skin-chest-malignant_melanoma	COSMIC cancer mutations	skin-chest-malignant_melanoma	114	2	16828	46	PTPRC,PREX2
3.884e-02	-3.25	cellular response to acidic pH	biological process	GO:0071468	15	1	18204	48	SLC9A1
3.884e-02	-3.25	pyramidal neuron differentiation	biological process	GO:0021859	15	1	18204	48	DISC1
3.884e-02	-3.25	negative regulation of androgen receptor signaling pathway	biological process	GO:0060766	15	1	18204	48	DAB2
3.884e-02	-3.25	positive regulation of granulocyte macrophage colony-stimulating factor production	biological process	GO:0032725	15	1	18204	48	SYK
3.884e-02	-3.25	regulation of sequestering of triglyceride	biological process	GO:0010889	15	1	18204	48	OSBPL8
3.884e-02	-3.25	negative regulation of axon regeneration	biological process	GO:0048681	15	1	18204	48	KREMEN1
3.884e-02	-3.25	negative regulation of B cell mediated immunity	biological process	GO:0002713	15	1	18204	48	PTPN6
3.884e-02	-3.25	negative regulation of immunoglobulin mediated immune response	biological process	GO:0002890	15	1	18204	48	PTPN6
3.884e-02	-3.25	neutrophil activation involved in immune response	biological process	GO:0002283	15	1	18204	48	SYK
3.884e-02	-3.25	positive regulation of non-canonical Wnt signaling pathway	biological process	GO:2000052	15	1	18204	48	DAB2
3.884e-02	-3.25	positive regulation of monocyte chemotactic protein-1 production	biological process	GO:0071639	15	1	18204	48	SYK
3.884e-02	-3.25	regulation of steroid hormone biosynthetic process	biological process	GO:0090030	15	1	18204	48	DAB2
3.884e-02	-3.25	positive regulation of hormone metabolic process	biological process	GO:0032352	15	1	18204	48	DAB2
3.884e-02	-3.25	collagen-activated signaling pathway	biological process	GO:0038065	15	1	18204	48	SYK
3.884e-02	-3.25	regulation of isotype switching to IgG isotypes	biological process	GO:0048302	15	1	18204	48	PTPRC
3.884e-02	-3.25	establishment of endothelial intestinal barrier	biological process	GO:0090557	15	1	18204	48	RAPGEF6
3.887e-02	-3.25	negative regulation of signaling	biological process	GO:0023057	1485	8	18204	48	PTPRC,TMEM131L,PTPN6,KREMEN1,CADM4,SH2B3,PTGIR,DAB2
3.887e-02	-3.25	negative regulation of cell communication	biological process	GO:0010648	1485	8	18204	48	DAB2,PTGIR,SH2B3,CADM4,KREMEN1,PTPN6,PTPRC,TMEM131L
3.890e-02	-3.25	RHOH (ras homolog family member H)	protein interactions	399	509	4	19454	49	OSBPL8,PREX1,DAB2,SLC9A1
3.897e-02	-3.24	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	49	DIAPH2
3.897e-02	-3.24	FH2_Formin	interpro domains	IPR015425	15	1	18521	49	DIAPH2
3.901e-02	-3.24	DAB2 (DAB adaptor protein 2)	protein interactions	1601	124	2	19454	49	BMP2K,FCHO2
3.907e-02	-3.24	small GTPase binding	molecular function	GO:0031267	283	3	18094	48	RAPGEF6,DOCK2,DIAPH2
3.908e-02	-3.24	phospholipid scramblase activity	molecular function	GO:0017128	15	1	18094	48	VMP1
3.908e-02	-3.24	3'-5' DNA helicase activity	molecular function	GO:0043138	15	1	18094	48	ASCC3
3.908e-02	-3.24	hexosaminidase activity	molecular function	GO:0015929	15	1	18094	48	CEMIP
3.908e-02	-3.24	icosanoid receptor activity	molecular function	GO:0004953	15	1	18094	48	PTGIR
3.908e-02	-3.24	low-density lipoprotein particle receptor activity	molecular function	GO:0005041	15	1	18094	48	STAB1
3.935e-02	-3.24	perinuclear region of cytoplasm	cellular component	GO:0048471	735	5	19108	49	PREX1,SLC9A1,DAB2,DISC1,GALNT1
3.956e-02	-3.23	TNFRSF25 (TNF receptor superfamily member 25)	protein interactions	8718	16	1	19454	49	PTPN6
3.956e-02	-3.23	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	49	NACC2
3.956e-02	-3.23	KEL (Kell metallo-endopeptidase (Kell blood group))	protein interactions	3792	16	1	19454	49	SLC16A10
3.956e-02	-3.23	SLCO6A1 (solute carrier organic anion transporter family member 6A1)	protein interactions	133482	16	1	19454	49	SLC9A1
3.956e-02	-3.23	AKAP6 (A-kinase anchoring protein 6)	protein interactions	9472	16	1	19454	49	DISC1
3.956e-02	-3.23	RHO (rhodopsin)	protein interactions	6010	16	1	19454	49	GRK6
3.956e-02	-3.23	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	49	GALNT1
3.956e-02	-3.23	TAMALIN (trafficking regulator and scaffold protein tamalin)	protein interactions	160622	16	1	19454	49	SYK
3.956e-02	-3.23	SELPLG (selectin P ligand)	protein interactions	6404	16	1	19454	49	SYK
3.956e-02	-3.23	GPNMB (glycoprotein nmb)	protein interactions	10457	16	1	19454	49	TFEB
3.956e-02	-3.23	ZSCAN4 (zinc finger and SCAN domain containing 4)	protein interactions	201516	16	1	19454	49	HCK
3.958e-02	-3.23	SLC4A2 (solute carrier family 4 member 2)	protein interactions	6522	125	2	19454	49	CEMIP,PTGIR
3.958e-02	-3.23	CFC1 (cryptic, EGF-CFC family member 1)	protein interactions	55997	125	2	19454	49	SEMA4B,CEMIP
3.961e-02	-3.23	HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)	protein interactions	9146	512	4	19454	49	RHBDF2,SYK,VMP1,PPP1R7
3.972e-02	-3.23	FH2	pfam domains	PF02181	15	1	17795	48	DIAPH2
3.972e-02	-3.23	Signal regulatory protein (SIRP) family interactions	REACTOME pathways	R-HSA-391160	13	1	10285	32	PTPN6
3.974e-02	-3.23	endometrioid_carcinoma	COSMIC cancer mutations	endometrioid_carcinoma	15690	46	16828	46	TMCC3,ACACB,SH2B3,SEMA4B,GALNT1,ATG14,SLC9A1,GRK6,VAV3,VMP1,DOCK2,RHBDF2,PTGIR,BMP2K,PREX1,PREX2,DAB2,TFEB,KREMEN1,CADM4,MPP1,ACER2,SLC16A10,ENTPD1,STAB1,SYK,RAPGEF6,OSBPL8,PLXND1,RBM47,PPP1R7,SMOX,PPFIBP2,FCHO2,DOCK8,HCK,PTPRC,ASCC3,BLVRA,DIAPH2,DISC1,GAB1,PTPN6,NACC2,ATP10D,TMTC1
3.981e-02	-3.22	ATP_GRASP	prosite domains	PS50975	13	1	12186	38	ACACB
3.986e-02	-3.22	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	8	16828	46	ASCC3,PTGIR,HCK,RAPGEF6,ACACB,DOCK8,ENTPD1,STAB1
3.990e-02	-3.22	ATP-grasp fold, A domain	gene3d domains	3.30.1490.20	14	1	14470	42	ACACB
3.997e-02	-3.22	endometrium	COSMIC cancer mutations	endometrium	15692	46	16828	46	TMTC1,NACC2,PTPN6,GAB1,ATP10D,DISC1,BLVRA,DIAPH2,PTPRC,ASCC3,HCK,PPFIBP2,FCHO2,DOCK8,SMOX,OSBPL8,PPP1R7,PLXND1,RBM47,RAPGEF6,SYK,STAB1,ENTPD1,SLC16A10,CADM4,ACER2,MPP1,DAB2,TFEB,KREMEN1,PREX2,PREX1,RHBDF2,BMP2K,PTGIR,VAV3,VMP1,DOCK2,ATG14,SLC9A1,GRK6,GALNT1,SH2B3,SEMA4B,ACACB,TMCC3
3.998e-02	-3.22	cellular localization	biological process	GO:0051641	2660	12	18204	48	RAPGEF6,ATG14,FCHO2,VMP1,OSBPL8,DISC1,SYK,PTPRC,DAB2,HCK,RHBDF2,DOCK2
3.999e-02	-3.22	TCR signaling in naive CD8+ T cells	Pathway Interaction DB	cd8tcrpathway	48	2	2226	15	PTPRC,PTPN6
4.004e-02	-3.22	anatomical structure formation involved in morphogenesis	biological process	GO:0048646	964	6	18204	48	VAV3,GAB1,SYK,PTPN6,PLXND1,DOCK2
4.016e-02	-3.21	ANP32A (acidic nuclear phosphoprotein 32 family member A)	protein interactions	8125	126	2	19454	49	DOCK8,PTPRC
4.020e-02	-3.21	positive regulation of innate immune response	biological process	GO:0045089	288	3	18204	48	SYK,RBM47,HCK
4.024e-02	-3.21	hypothalamus	COSMIC cancer mutations	hypothalamus	15	1	16828	46	NACC2
4.038e-02	-3.21	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	6	16828	46	SYK,GRK6,PREX2,BMP2K,ACACB,HCK
4.052e-02	-3.21	negative regulation of immune effector process	biological process	GO:0002698	121	2	18204	48	PTPRC,PTPN6
4.052e-02	-3.21	positive regulation of T cell differentiation	biological process	GO:0045582	121	2	18204	48	PTPRC,SYK
4.064e-02	-3.20	SEC61B (SEC61 translocon subunit beta)	protein interactions	10952	755	5	19454	49	VMP1,TMCC3,SLC9A1,TMEM131L,OSBPL8
4.108e-02	-3.19	C3orf52 (chromosome 3 open reading frame 52)	protein interactions	79669	304	3	19454	49	SLC9A1,OSBPL8,RHBDF2
4.138e-02	-3.18	positive regulation of B cell differentiation	biological process	GO:0045579	16	1	18204	48	SYK
4.138e-02	-3.18	hyaluronan catabolic process	biological process	GO:0030214	16	1	18204	48	CEMIP
4.138e-02	-3.18	tricarboxylic acid metabolic process	biological process	GO:0072350	16	1	18204	48	ACACB
4.138e-02	-3.18	neutrophil homeostasis	biological process	GO:0001780	16	1	18204	48	SH2B3
4.138e-02	-3.18	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	48	DAB2
4.138e-02	-3.18	regulation of corticosteroid hormone secretion	biological process	GO:2000846	16	1	18204	48	DAB2
4.138e-02	-3.18	branching involved in salivary gland morphogenesis	biological process	GO:0060445	16	1	18204	48	PLXND1
4.138e-02	-3.18	thyroid hormone generation	biological process	GO:0006590	16	1	18204	48	SLC16A10
4.138e-02	-3.18	negative regulation of neuron projection regeneration	biological process	GO:0070571	16	1	18204	48	KREMEN1
4.138e-02	-3.18	natural killer cell differentiation	biological process	GO:0001779	16	1	18204	48	PTPRC
4.152e-02	-3.18	Guanylate_kinase_CS	interpro domains	IPR020590	16	1	18521	49	MPP1
4.152e-02	-3.18	Kringle_sf	interpro domains	IPR038178	16	1	18521	49	KREMEN1
4.152e-02	-3.18	Kringle	interpro domains	IPR000001	16	1	18521	49	KREMEN1
4.152e-02	-3.18	Kringle_CS	interpro domains	IPR018056	16	1	18521	49	KREMEN1
4.163e-02	-3.18	flippase activity	molecular function	GO:0140327	16	1	18094	48	ATP10D
4.163e-02	-3.18	sodium:proton antiporter activity	molecular function	GO:0015385	16	1	18094	48	SLC9A1
4.182e-02	-3.17	regulation of anatomical structure size	biological process	GO:0090066	498	4	18204	48	DISC1,HCK,VAV3,PREX1
4.190e-02	-3.17	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	2	19454	49	DAB2,FCHO2
4.190e-02	-3.17	COL8A1 (collagen type VIII alpha 1 chain)	protein interactions	1295	129	2	19454	49	DISC1,BMP2K
4.198e-02	-3.17	OLFM1 (olfactomedin 1)	protein interactions	10439	17	1	19454	49	DISC1
4.198e-02	-3.17	SLAMF6 (SLAM family member 6)	protein interactions	114836	17	1	19454	49	PTPN6
4.198e-02	-3.17	NYX (nyctalopin)	protein interactions	60506	17	1	19454	49	GALNT1
4.198e-02	-3.17	MRAS (muscle RAS oncogene homolog)	protein interactions	22808	17	1	19454	49	RAPGEF6
4.198e-02	-3.17	DUXB (double homeobox B)	protein interactions	100033411	17	1	19454	49	ACACB
4.198e-02	-3.17	GYPC (glycophorin C (Gerbich blood group))	protein interactions	2995	17	1	19454	49	MPP1
4.198e-02	-3.17	SLC25A21 (solute carrier family 25 member 21)	protein interactions	89874	17	1	19454	49	BLVRA
4.198e-02	-3.17	FAM131C (family with sequence similarity 131 member C)	protein interactions	348487	17	1	19454	49	RHBDF2
4.198e-02	-3.17	STRA6 (signaling receptor and transporter of retinol STRA6)	protein interactions	64220	17	1	19454	49	SLC9A1
4.210e-02	-3.17	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	15	16828	46	TMTC1,SLC9A1,GRK6,SLC16A10,RAPGEF6,ATP10D,GALNT1,KREMEN1,STAB1,PREX2,SEMA4B,PTPRC,ASCC3,DOCK2,SMOX
4.216e-02	-3.17	phosphorylation	biological process	GO:0016310	729	5	18204	48	SYK,PTPN6,BMP2K,GRK6,HCK
4.231e-02	-3.16	Kringle	pfam domains	PF00051	16	1	17795	48	KREMEN1
4.236e-02	-3.16	regulation of ossification	biological process	GO:0030278	124	2	18204	48	KREMEN1,BMP2K
4.247e-02	-3.16	TGOLN2 (trans-golgi network protein 2)	protein interactions	10618	1581	8	19454	49	PLXND1,SEMA4B,FCHO2,BMP2K,TMEM131L,DAB2,GALNT1,VMP1
4.248e-02	-3.16	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	15	16828	46	VAV3,DOCK8,PTPRC,HCK,ACACB,DAB2,TFEB,PREX2,DIAPH2,BLVRA,OSBPL8,TMTC1,RBM47,ACER2,ATP10D
4.248e-02	-3.16	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	15	16828	46	TFEB,DAB2,PREX2,DIAPH2,BLVRA,RBM47,OSBPL8,TMTC1,ACER2,ATP10D,DOCK8,VAV3,PTPRC,HCK,ACACB
4.269e-02	-3.15	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	42	DIAPH2
4.271e-02	-3.15	Regulation of IFNG signaling	REACTOME pathways	R-HSA-877312	14	1	10285	32	PTPN6
4.281e-02	-3.15	MHD	prosite domains	PS51072	14	1	12186	38	FCHO2
4.281e-02	-3.15	LINK_2	prosite domains	PS50963	14	1	12186	38	STAB1
4.304e-02	-3.15	EZR (ezrin)	protein interactions	7430	526	4	19454	49	GAB1,SYK,PTPRC,FCHO2
4.308e-02	-3.14	LGALS7 (galectin 7)	protein interactions	3963	131	2	19454	49	DOCK8,GAB1
4.312e-02	-3.14	protein phosphorylation	biological process	GO:0006468	503	4	18204	48	HCK,GRK6,PTPN6,SYK
4.312e-02	-3.14	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	3	19454	49	FCHO2,GAB1,OSBPL8
4.321e-02	-3.14	cellular response to cytokine stimulus	biological process	GO:0071345	734	5	18204	48	HCK,PTPN6,SH2B3,SYK,DOCK8
4.344e-02	-3.14	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	2	10285	32	SLC9A1,SLC16A10
4.345e-02	-3.14	protein tyrosine kinase binding	molecular function	GO:1990782	125	2	18094	48	SH2B3,CADM4
4.349e-02	-3.14	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	4	16828	46	GRK6,SYK,BMP2K,HCK
4.367e-02	-3.13	DDR2 (discoidin domain receptor tyrosine kinase 2)	protein interactions	4921	132	2	19454	49	VMP1,OSBPL8
4.367e-02	-3.13	TRIM52 (tripartite motif containing 52)	protein interactions	84851	132	2	19454	49	DISC1,ASCC3
4.367e-02	-3.13	TXNDC12 (thioredoxin domain containing 12)	protein interactions	51060	132	2	19454	49	DIAPH2,HCK
4.371e-02	-3.13	Proteoglycans in cancer	KEGG pathways	hsa05205	203	3	7161	28	SLC9A1,PTPN6,GAB1
4.371e-02	-3.13	Proteoglycans in cancer	KEGG pathways	ko05205	203	3	7161	28	GAB1,SLC9A1,PTPN6
4.379e-02	-3.13	ENO1 (enolase 1)	protein interactions	2023	529	4	19454	49	SLC9A1,TMCC3,RAPGEF6,ASCC3
4.382e-02	-3.13	organelle membrane	cellular component	GO:0031090	3742	15	19108	49	SMOX,ATG14,OSBPL8,ACER2,CEMIP,GALNT1,VMP1,RHBDF2,ACACB,PTPRC,TFEB,DAB2,ATP10D,STAB1,TMCC3
4.391e-02	-3.13	negative regulation of vascular endothelial growth factor signaling pathway	biological process	GO:1900747	17	1	18204	48	CADM4
4.391e-02	-3.13	response to hepatocyte growth factor	biological process	GO:0035728	17	1	18204	48	GAB1
4.391e-02	-3.13	microvillus assembly	biological process	GO:0030033	17	1	18204	48	RAPGEF6
4.391e-02	-3.13	negative regulation of neuroinflammatory response	biological process	GO:0150079	17	1	18204	48	PTPRC
4.391e-02	-3.13	NADPH regeneration	biological process	GO:0006740	17	1	18204	48	ACACB
4.391e-02	-3.13	negative regulation of humoral immune response	biological process	GO:0002921	17	1	18204	48	PTPN6
4.391e-02	-3.13	negative regulation of macrophage activation	biological process	GO:0043031	17	1	18204	48	PTPRC
4.417e-02	-3.12	nucleoside diphosphate phosphatase activity	molecular function	GO:0017110	17	1	18094	48	ENTPD1
4.417e-02	-3.12	transmembrane receptor protein tyrosine kinase adaptor activity	molecular function	GO:0005068	17	1	18094	48	SH2B3
4.417e-02	-3.12	low-density lipoprotein particle binding	molecular function	GO:0030169	17	1	18094	48	STAB1
4.422e-02	-3.12	negative regulation of neuron projection development	biological process	GO:0010977	127	2	18204	48	DAB2,KREMEN1
4.427e-02	-3.12	HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1)	protein interactions	3117	133	2	19454	49	TMEM131L,SEMA4B
4.433e-02	-3.12	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	12	16828	46	DOCK2,VAV3,SMOX,ACACB,SYK,DAB2,PREX2,SLC9A1,PLXND1,SLC16A10,OSBPL8,GAB1
4.440e-02	-3.11	ADO (2-aminoethanethiol dioxygenase)	protein interactions	84890	18	1	19454	49	DISC1
4.440e-02	-3.11	SPARCL1 (SPARC like 1)	protein interactions	8404	18	1	19454	49	DISC1
4.440e-02	-3.11	ZNF365 (zinc finger protein 365)	protein interactions	22891	18	1	19454	49	DISC1
4.440e-02	-3.11	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	49	GALNT1
4.440e-02	-3.11	ARHGDIG (Rho GDP dissociation inhibitor gamma)	protein interactions	398	18	1	19454	49	CEMIP
4.440e-02	-3.11	Numb (NUMB endocytic adaptor protein)	protein interactions	18222	18	1	19454	49	BMP2K
4.440e-02	-3.11	Chmp6 (charged multivesicular body protein 6)	protein interactions	208092	18	1	19454	49	PTPN6
4.440e-02	-3.11	PROSER3 (proline and serine rich 3)	protein interactions	148137	18	1	19454	49	CEMIP
4.440e-02	-3.11	DNAAF11 (dynein axonemal assembly factor 11)	protein interactions	23639	18	1	19454	49	PPP1R7
4.440e-02	-3.11	CNDP1 (carnosine dipeptidase 1)	protein interactions	84735	18	1	19454	49	SLC16A10
4.440e-02	-3.11	DCAF17 (DDB1 and CUL4 associated factor 17)	protein interactions	80067	18	1	19454	49	PREX1
4.440e-02	-3.11	SRR (serine racemase)	protein interactions	63826	18	1	19454	49	DISC1
4.451e-02	-3.11	ATP5PO (ATP synthase peripheral stalk subunit OSCP)	protein interactions	539	314	3	19454	49	GRK6,PREX1,DOCK8
4.485e-02	-3.10	regulation of protein binding	biological process	GO:0043393	128	2	18204	48	DISC1,DAB2
4.487e-02	-3.10	ARL4C (ADP ribosylation factor like GTPase 4C)	protein interactions	10123	134	2	19454	49	CADM4,GAB1
4.487e-02	-3.10	SLU7 (SLU7 homolog, splicing factor)	protein interactions	10569	134	2	19454	49	ACACB,PHKB
4.487e-02	-3.10	non_seminoma	COSMIC cancer mutations	non_seminoma	492	4	16828	46	HCK,BMP2K,SYK,GRK6
4.502e-02	-3.10	positive regulation of cell population proliferation	biological process	GO:0008284	992	6	18204	48	ACER2,HCK,PTPN6,PTPRC,DISC1,VAV3
4.515e-02	-3.10	skin-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma	493	4	16828	46	SYK,SH2B3,PREX2,BMP2K
4.519e-02	-3.10	T-Cell antigen Receptor (TCR) Signaling Pathway	WikiPathways	WP69	91	2	5310	20	VAV3,SH2B3
4.525e-02	-3.10	kinase activity	molecular function	GO:0016301	739	5	18094	48	HCK,GRK6,BMP2K,SYK,MPP1
4.547e-02	-3.09	Plasminogen Kringle 4	gene3d domains	2.40.20.10	16	1	14470	42	KREMEN1
4.547e-02	-3.09	JAK3 (Janus kinase 3)	protein interactions	3718	135	2	19454	49	PTPRC,PTPN6
4.547e-02	-3.09	URI1 (URI1 prefoldin like chaperone)	protein interactions	8725	135	2	19454	49	GRK6,PPP1R7
4.549e-02	-3.09	chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	COSMIC cancer mutations	chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	17	1	16828	46	SH2B3
4.549e-02	-3.09	optic_nerve	COSMIC cancer mutations	optic_nerve	17	1	16828	46	NACC2
4.549e-02	-3.09	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	17	1	16828	46	SH2B3
4.549e-02	-3.09	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	17	1	16828	46	NACC2
4.557e-02	-3.09	protein-macromolecule adaptor activity	molecular function	GO:0030674	989	6	18094	48	DAB2,RBM47,SH2B3,GAB1,SLC9A1,ATG14
4.558e-02	-3.09	IQGAP1 (IQ motif containing GTPase activating protein 1)	protein interactions	8826	536	4	19454	49	ASCC3,BMP2K,VMP1,DAB2
4.570e-02	-3.09	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	REACTOME pathways	R-HSA-3772470	15	1	10285	32	KREMEN1
4.570e-02	-3.09	Eicosanoid ligand-binding receptors	REACTOME pathways	R-HSA-391903	15	1	10285	32	PTGIR
4.579e-02	-3.08	FH2	prosite domains	PS51444	15	1	12186	38	DIAPH2
4.597e-02	-3.08	cellular response to chemical stimulus	biological process	GO:0070887	2411	11	18204	48	SH2B3,PREX1,ACER2,GAB1,VAV3,HCK,SYK,DOCK8,PTPN6,SLC9A1,SMOX
4.608e-02	-3.08	NAF1 (nuclear assembly factor 1 ribonucleoprotein)	protein interactions	92345	136	2	19454	49	SYK,MPP1
4.611e-02	-3.08	negative regulation of T cell activation	biological process	GO:0050868	130	2	18204	48	TMEM131L,PTPN6
4.611e-02	-3.08	B cell differentiation	biological process	GO:0030183	130	2	18204	48	SYK,PTPRC
4.615e-02	-3.08	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	46	16828	46	SMOX,PPFIBP2,FCHO2,DOCK8,HCK,PTPRC,ASCC3,DIAPH2,BLVRA,DISC1,PTPN6,NACC2,GAB1,ATP10D,TMTC1,ENTPD1,STAB1,SYK,RAPGEF6,OSBPL8,RBM47,PLXND1,PPP1R7,VAV3,VMP1,DOCK2,RHBDF2,BMP2K,PTGIR,PREX1,PREX2,DAB2,TFEB,KREMEN1,CADM4,ACER2,MPP1,SLC16A10,TMCC3,ACACB,SH2B3,SEMA4B,GALNT1,ATG14,SLC9A1,GRK6
4.621e-02	-3.07	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	8	18094	48	ATP10D,ASCC3,SYK,BMP2K,ENTPD1,GRK6,ACACB,HCK
4.634e-02	-3.07	endoplasmic reticulum-Golgi intermediate compartment	cellular component	GO:0005793	134	2	19108	49	GALNT1,VMP1
4.643e-02	-3.07	positive regulation of sodium ion transmembrane transport	biological process	GO:1902307	18	1	18204	48	SLC9A1
4.643e-02	-3.07	regulation of cardiac muscle adaptation	biological process	GO:0010612	18	1	18204	48	ACACB
4.643e-02	-3.07	negative regulation of platelet activation	biological process	GO:0010544	18	1	18204	48	SH2B3
4.643e-02	-3.07	regulation of granulocyte macrophage colony-stimulating factor production	biological process	GO:0032645	18	1	18204	48	SYK
4.643e-02	-3.07	positive regulation of superoxide anion generation	biological process	GO:0032930	18	1	18204	48	SYK
4.643e-02	-3.07	regulation of cardiac muscle hypertrophy in response to stress	biological process	GO:1903242	18	1	18204	48	ACACB
4.643e-02	-3.07	maintenance of cell polarity	biological process	GO:0030011	18	1	18204	48	SLC9A1
4.651e-02	-3.07	nuclear membrane	cellular component	GO:0031965	314	3	19108	49	OSBPL8,CEMIP,SMOX
4.654e-02	-3.07	LINK	smart domains	SM00445	14	1	9717	33	STAB1
4.654e-02	-3.07	4.1m	smart domains	SM00294	14	1	9717	33	CADM4
4.659e-02	-3.07	EGF_dom	interpro domains	IPR024731	18	1	18521	49	STAB1
4.659e-02	-3.07	Leu-rich_rpt_4	interpro domains	IPR025875	18	1	18521	49	PPP1R7
4.671e-02	-3.06	defense response to bacterium	biological process	GO:0042742	306	3	18204	48	STAB1,SYK,TFEB
4.671e-02	-3.06	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	48	PTPRC
4.671e-02	-3.06	lipoprotein particle receptor activity	molecular function	GO:0030228	18	1	18094	48	STAB1
4.671e-02	-3.06	clathrin adaptor activity	molecular function	GO:0035615	18	1	18094	48	DAB2
4.675e-02	-3.06	positive regulation of cysteine-type endopeptidase activity	biological process	GO:2001056	131	2	18204	48	ACER2,SYK
4.681e-02	-3.06	NLGN1 (neuroligin 1)	protein interactions	22871	19	1	19454	49	SEMA4B
4.681e-02	-3.06	ICOSLG (inducible T cell costimulator ligand)	protein interactions	23308	19	1	19454	49	TMEM131L
4.681e-02	-3.06	NHERF4 (NHERF family PDZ scaffold protein 4)	protein interactions	79849	19	1	19454	49	PTGIR
4.681e-02	-3.06	RCVRN (recoverin)	protein interactions	5957	19	1	19454	49	GRK6
4.681e-02	-3.06	HTR3B (5-hydroxytryptamine receptor 3B)	protein interactions	9177	19	1	19454	49	SLC9A1
4.681e-02	-3.06	TBX20 (T-box transcription factor 20)	protein interactions	57057	19	1	19454	49	BLVRA
4.681e-02	-3.06	SIT1 (signaling threshold regulating transmembrane adaptor 1)	protein interactions	27240	19	1	19454	49	SYK
4.681e-02	-3.06	PEX2 (peroxisomal biogenesis factor 2)	protein interactions	5828	19	1	19454	49	PTPN6
4.681e-02	-3.06	SLITRK3 (SLIT and NTRK like family member 3)	protein interactions	22865	19	1	19454	49	RHBDF2
4.681e-02	-3.06	CRYBB1 (crystallin beta B1)	protein interactions	1414	19	1	19454	49	DISC1
4.681e-02	-3.06	HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1)	protein interactions	54511	19	1	19454	49	CEMIP
4.681e-02	-3.06	ZNF197 (zinc finger protein 197)	protein interactions	10168	19	1	19454	49	DISC1
4.699e-02	-3.06	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	49	PPP1R7,CADM4,SLC16A10
4.715e-02	-3.05	intracellular anatomical structure	cellular component	GO:0005622	15205	44	19108	49	ASCC3,SLC9A1,HCK,DOCK8,FCHO2,PHKB,VAV3,NACC2,ATP10D,TMTC1,PTGIR,GAB1,BLVRA,PTPRC,CEMIP,GALNT1,SMOX,PREX1,SH2B3,OSBPL8,DISC1,RBM47,TMCC3,BMP2K,DIAPH2,TFEB,GRK6,ACER2,SLC16A10,ATG14,PTPN6,PPP1R7,DAB2,RHBDF2,ACACB,MPP1,SYK,RAPGEF6,PPFIBP2,STAB1,PREX2,VMP1,DOCK2,TMEM131L
4.716e-02	-3.05	peptidyl-amino acid modification	biological process	GO:0018193	518	4	18204	48	SYK,PTPN6,GALNT1,HCK
4.730e-02	-3.05	EXOC1 (exocyst complex component 1)	protein interactions	55763	138	2	19454	49	ATG14,DISC1
4.730e-02	-3.05	AKAP12 (A-kinase anchoring protein 12)	protein interactions	9590	138	2	19454	49	RHBDF2,HCK
4.739e-02	-3.05	positive regulation of proteolysis involved in protein catabolic process	biological process	GO:1903052	132	2	18204	48	DISC1,DAB2
4.748e-02	-3.05	EGF_3	pfam domains	PF12947	18	1	17795	48	STAB1
4.748e-02	-3.05	LRR_4	pfam domains	PF12799	18	1	17795	48	PPP1R7
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	SLC9A1
4.765e-02	-3.04	defense response to other organism	biological process	GO:0098542	1006	6	18204	48	PTPN6,STAB1,PTPRC,SYK,TFEB,HCK
4.771e-02	-3.04	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	4	16828	46	GRK6,SYK,HCK,BMP2K
4.785e-02	-3.04	anion binding	molecular function	GO:0043168	2412	11	18094	48	RAPGEF6,ASCC3,BMP2K,GRK6,ENTPD1,SYK,ATP10D,ACACB,FCHO2,HCK,SLC9A1
4.792e-02	-3.04	DPPA4 (developmental pluripotency associated 4)	protein interactions	55211	139	2	19454	49	ACACB,TMTC1
4.792e-02	-3.04	ARMC6 (armadillo repeat containing 6)	protein interactions	93436	139	2	19454	49	GALNT1,SLC16A10
4.792e-02	-3.04	DUSP22 (dual specificity phosphatase 22)	protein interactions	56940	139	2	19454	49	ACACB,PTPN6
4.802e-02	-3.04	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	48	SYK,HCK
4.810e-02	-3.03	Regulation of actin cytoskeleton	KEGG pathways	ko04810	211	3	7161	28	DIAPH2,SLC9A1,VAV3
4.810e-02	-3.03	Regulation of actin cytoskeleton	KEGG pathways	hsa04810	211	3	7161	28	SLC9A1,DIAPH2,VAV3
4.824e-02	-3.03	-	gene3d domains	2.40.50.100	17	1	14470	42	ACACB
4.834e-02	-3.03	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	2	18521	49	HCK,SYK
4.835e-02	-3.03	coated vesicle	cellular component	GO:0030135	319	3	19108	49	CEMIP,DAB2,FCHO2
4.853e-02	-3.03	PTPRO (protein tyrosine phosphatase receptor type O)	protein interactions	5800	140	2	19454	49	SYK,TMEM131L
4.853e-02	-3.03	PCDHB3 (protocadherin beta 3)	protein interactions	56132	140	2	19454	49	TMEM131L,RHBDF2
4.867e-02	-3.02	Signaling by EGFRvIII in Cancer	REACTOME pathways	R-HSA-5637812	16	1	10285	32	GAB1
4.867e-02	-3.02	Constitutive Signaling by EGFRvIII	REACTOME pathways	R-HSA-5637810	16	1	10285	32	GAB1
4.867e-02	-3.02	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	32	GAB1
4.869e-02	-3.02	organelle disassembly	biological process	GO:1903008	134	2	18204	48	ASCC3,ATG14
4.869e-02	-3.02	regulation of actin filament polymerization	biological process	GO:0030833	134	2	18204	48	HCK,PREX1
4.877e-02	-3.02	GUANYLATE_KINASE_1	prosite domains	PS00856	16	1	12186	38	MPP1
4.877e-02	-3.02	KRINGLE_2	prosite domains	PS50070	16	1	12186	38	KREMEN1
4.877e-02	-3.02	KRINGLE_1	prosite domains	PS00021	16	1	12186	38	KREMEN1
4.880e-02	-3.02	DTX2 (deltex E3 ubiquitin ligase 2)	protein interactions	113878	326	3	19454	49	ACACB,RBM47,DAB2
4.884e-02	-3.02	clathrin-coated vesicle membrane	cellular component	GO:0030665	138	2	19108	49	DAB2,CEMIP
4.895e-02	-3.02	negative regulation of cellular response to vascular endothelial growth factor stimulus	biological process	GO:1902548	19	1	18204	48	CADM4
4.895e-02	-3.02	positive regulation of bone resorption	biological process	GO:0045780	19	1	18204	48	SYK
4.895e-02	-3.02	response to mitochondrial depolarisation	biological process	GO:0098780	19	1	18204	48	ATG14
4.895e-02	-3.02	regulation of microglial cell activation	biological process	GO:1903978	19	1	18204	48	PTPRC
4.895e-02	-3.02	leukotriene biosynthetic process	biological process	GO:0019370	19	1	18204	48	SYK
4.895e-02	-3.02	amine catabolic process	biological process	GO:0009310	19	1	18204	48	SMOX
4.895e-02	-3.02	cellular biogenic amine catabolic process	biological process	GO:0042402	19	1	18204	48	SMOX
4.895e-02	-3.02	base conversion or substitution editing	biological process	GO:0016553	19	1	18204	48	RBM47
4.895e-02	-3.02	detection of temperature stimulus involved in sensory perception of pain	biological process	GO:0050965	19	1	18204	48	DISC1
4.895e-02	-3.02	regulation of early endosome to late endosome transport	biological process	GO:2000641	19	1	18204	48	DAB2
4.895e-02	-3.02	positive regulation of phosphoprotein phosphatase activity	biological process	GO:0032516	19	1	18204	48	PTPRC
4.895e-02	-3.02	microvillus organization	biological process	GO:0032528	19	1	18204	48	RAPGEF6
4.895e-02	-3.02	protein O-linked mannosylation	biological process	GO:0035269	19	1	18204	48	TMTC1
4.895e-02	-3.02	response to aldosterone	biological process	GO:1904044	19	1	18204	48	PTPRC
4.895e-02	-3.02	polyamine metabolic process	biological process	GO:0006595	19	1	18204	48	SMOX
4.895e-02	-3.02	lipoprotein transport	biological process	GO:0042953	19	1	18204	48	VMP1
4.895e-02	-3.02	macrophage activation involved in immune response	biological process	GO:0002281	19	1	18204	48	SYK
4.895e-02	-3.02	regulation of mast cell activation	biological process	GO:0033003	19	1	18204	48	PTPN6
4.895e-02	-3.02	production of molecular mediator involved in inflammatory response	biological process	GO:0002532	19	1	18204	48	SYK
4.895e-02	-3.02	negative regulation of peptidyl-threonine phosphorylation	biological process	GO:0010801	19	1	18204	48	CADM4
4.901e-02	-3.02	protein-containing complex assembly	biological process	GO:0065003	1279	7	18204	48	FCHO2,DIAPH2,NACC2,SLC9A1,DAB2,PREX1,ACACB
4.910e-02	-3.01	Kinase-like_dom_sf	interpro domains	IPR011009	523	4	18521	49	GRK6,HCK,BMP2K,SYK
4.916e-02	-3.01	UPK2 (uroplakin 2)	protein interactions	7379	141	2	19454	49	TMEM131L,SLC16A10
4.921e-02	-3.01	RARRES1 (retinoic acid receptor responder 1)	protein interactions	5918	20	1	19454	49	RAPGEF6
4.921e-02	-3.01	MYF6 (myogenic factor 6)	protein interactions	4618	20	1	19454	49	DISC1
4.921e-02	-3.01	JPH2 (junctophilin 2)	protein interactions	57158	20	1	19454	49	TMTC1
4.921e-02	-3.01	GGT1 (gamma-glutamyltransferase 1)	protein interactions	2678	20	1	19454	49	CEMIP
4.921e-02	-3.01	TSPAN16 (tetraspanin 16)	protein interactions	26526	20	1	19454	49	CADM4
4.921e-02	-3.01	HSD17B7P2 (hydroxysteroid 17-beta dehydrogenase 7 pseudogene 2)	protein interactions	158160	20	1	19454	49	ASCC3
4.921e-02	-3.01	CCDC197 (coiled-coil domain containing 197)	protein interactions	256369	20	1	19454	49	DISC1
4.921e-02	-3.01	NUTM2F (NUT family member 2F)	protein interactions	54754	20	1	19454	49	RBM47
4.921e-02	-3.01	SNCB (synuclein beta)	protein interactions	6620	20	1	19454	49	GRK6
4.924e-02	-3.01	ankyrin binding	molecular function	GO:0030506	19	1	18094	48	PTPRC
4.924e-02	-3.01	solute:potassium antiporter activity	molecular function	GO:0022821	19	1	18094	48	SLC9A1
4.924e-02	-3.01	cargo adaptor activity	molecular function	GO:0140312	19	1	18094	48	DAB2
4.924e-02	-3.01	polypeptide N-acetylgalactosaminyltransferase activity	molecular function	GO:0004653	19	1	18094	48	GALNT1
4.934e-02	-3.01	positive regulation of lymphocyte differentiation	biological process	GO:0045621	135	2	18204	48	SYK,PTPRC
4.934e-02	-3.01	positive regulation of production of molecular mediator of immune response	biological process	GO:0002702	135	2	18204	48	PTPRC,SYK
4.943e-02	-3.01	human chr5p13.1	chromosome location	human chr5p13.1	27	1	26134	49	DAB2
4.945e-02	-3.01	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	4	16828	46	SYK,GRK6,BMP2K,HCK
4.956e-02	-3.00	bounding membrane of organelle	cellular component	GO:0098588	2198	10	19108	49	GALNT1,CEMIP,ACER2,STAB1,ATG14,DAB2,TFEB,PTPRC,ACACB,VMP1
4.957e-02	-3.00	PDGFR-beta signaling pathway	Pathway Interaction DB	pdgfrbpathway	54	2	2226	15	HCK,GAB1
4.970e-02	-3.00	Fatty acid biosynthesis	KEGG pathways	hsa00061	13	1	7161	28	ACACB
4.970e-02	-3.00	Fatty acid biosynthesis	KEGG pathways	ko00061	13	1	7161	28	ACACB
4.976e-02	-3.00	positive regulation of response to biotic stimulus	biological process	GO:0002833	314	3	18204	48	RBM47,SYK,HCK
4.978e-02	-3.00	ERLIN1 (ER lipid raft associated 1)	protein interactions	10613	142	2	19454	49	DISC1,OSBPL8
4.978e-02	-3.00	Myh10 (myosin, heavy polypeptide 10, non-muscle)	protein interactions	77579	142	2	19454	49	DAB2,BMP2K
4.978e-02	-3.00	FH2	smart domains	SM00498	15	1	9717	33	DIAPH2
4.986e-02	-3.00	embryonal	COSMIC cancer mutations	embryonal	2659	12	16828	46	VAV3,DOCK8,VMP1,PTPRC,ACACB,DAB2,SH2B3,DIAPH2,PREX2,PLXND1,PTPN6,NACC2
4.986e-02	-3.00	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	12	16828	46	PLXND1,PTPN6,NACC2,DAB2,PREX2,DIAPH2,SH2B3,PTPRC,ACACB,VMP1,DOCK8,VAV3
4.999e-02	-3.00	protein dephosphorylation	biological process	GO:0006470	136	2	18204	48	PTPN6,PTPRC