Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.599e-31	-70.91	synapse	cellular component	GO:0045202	1473	37	19108	49	CADPS,CHRM2,KCNIP2,OLFM1,GRIK2,SCN8A,CNTN5,GRIN1,CELF4,NRXN2,NRG3,CACNA1G,RIMS2,GABBR2,GRID2,SYT1,GABRA1,STXBP5,KCNC1,GPHN,CACNA1A,GRM7,NRXN1,DLG3,GABRB2,PDE2A,GRIA3,GRIN2B,FGF12,MCTP1,HCN1,SYT7,GABRD,KCNMA1,KCTD16,ASIC2,DLG4
3.667e-31	-70.08	synaptic membrane	cellular component	GO:0097060	400	26	19108	49	GRIA3,PDE2A,GABRB2,DLG3,GPHN,GRM7,NRXN1,KCNC1,DLG4,KCTD16,KCNMA1,GABRD,SYT7,HCN1,GRIN2B,NRXN2,CNTN5,SCN8A,GRIN1,GRIK2,CHRM2,GABRA1,SYT1,GRID2,GABBR2,RIMS2
4.036e-29	-65.38	anterograde trans-synaptic signaling	biological process	GO:0098916	415	25	18204	47	DLG3,RIMS2,GABRB2,GABRA1,GRID2,GRIA3,KCNIP2,ASIC2,CACNA1A,GABRD,CACNA1G,GRIN2B,GRIK2,NRXN1,NRXN2,SYT1,CELF4,GRM7,GRIN1,SYT7,CHRM2,CADPS,DLG4,GABBR2,FGF12
4.036e-29	-65.38	chemical synaptic transmission	biological process	GO:0007268	415	25	18204	47	GRM7,CELF4,GRIN1,SYT7,CADPS,CHRM2,GABBR2,FGF12,DLG4,GRIK2,NRXN1,SYT1,NRXN2,ASIC2,CACNA1A,GABRD,CACNA1G,GRIN2B,RIMS2,DLG3,GABRB2,GABRA1,KCNIP2,GRID2,GRIA3
1.048e-28	-64.43	trans-synaptic signaling	biological process	GO:0099537	431	25	18204	47	GRID2,GRIA3,KCNIP2,RIMS2,DLG3,GABRB2,GABRA1,CACNA1G,GRIN2B,ASIC2,CACNA1A,GABRD,NRXN1,NRXN2,SYT1,GRIK2,CHRM2,CADPS,DLG4,GABBR2,FGF12,CELF4,GRM7,GRIN1,SYT7
5.112e-28	-62.84	synaptic signaling	biological process	GO:0099536	459	25	18204	47	GRIK2,NRXN1,SYT1,NRXN2,GRM7,CELF4,SYT7,GRIN1,CHRM2,CADPS,FGF12,GABBR2,DLG4,DLG3,RIMS2,GABRA1,GABRB2,KCNIP2,GRIA3,GRID2,ASIC2,CACNA1A,GABRD,GRIN2B,CACNA1G
4.694e-25	-56.02	cell junction	cellular component	GO:0030054	2224	37	19108	49	KCTD16,DLG4,ASIC2,KCNMA1,FGF12,MCTP1,HCN1,SYT7,GABRD,GRIN2B,GRIA3,GABRB2,PDE2A,KCNC1,GPHN,NRXN1,CACNA1A,GRM7,DLG3,STXBP5,SYT1,GABRA1,GRID2,CACNA1G,RIMS2,GABBR2,NRG3,CELF4,NRXN2,KCNIP2,GRIK2,OLFM1,CNTN5,SCN8A,GRIN1,CADPS,CHRM2
9.784e-23	-50.68	postsynaptic membrane	cellular component	GO:0045211	280	19	19108	49	GRID2,GABRD,HCN1,GABBR2,GRIN2B,DLG4,KCTD16,KCNMA1,GABRA1,GRIN1,SCN8A,GABRB2,GRIK2,GRM7,GPHN,DLG3,KCNC1,CHRM2,GRIA3
1.297e-22	-50.40	monoatomic ion channel complex	cellular component	GO:0034702	344	20	19108	49	HCN1,GABRD,GRID2,GRIN2B,CACNA1G,STXBP5,DLG4,CACNA1H,GABRA1,KCNMA1,GRIK2,KCNIP2,GABRB2,SCN8A,GRIN1,KCNC1,DLG3,CACNA1A,DPP10,GRIA3
9.430e-22	-48.41	cell-cell signaling	biological process	GO:0007267	822	25	18204	47	DLG3,RIMS2,GABRB2,GABRA1,GRID2,GRIA3,KCNIP2,CACNA1A,ASIC2,GABRD,CACNA1G,GRIN2B,GRIK2,NRXN1,NRXN2,SYT1,CELF4,GRM7,GRIN1,SYT7,CADPS,CHRM2,DLG4,GABBR2,FGF12
1.420e-21	-48.00	regulation of membrane potential	biological process	GO:0042391	463	21	18204	47	GRIN1,GABRD,CACNA1H,CELF4,ASIC2,DLG4,FGF12,SCN8A,CACNA1G,GRIN2B,GRIK2,GABRB2,GABRA1,RIMS2,KCNMA1,HCN1,GRID2,NRXN1,KCNC1,GRIA3,KCNIP2
1.335e-20	-45.76	transmembrane transporter complex	cellular component	GO:1902495	434	20	19108	49	GABRA1,KCNMA1,DLG4,CACNA1H,STXBP5,CACNA1G,GRIN2B,GABRD,GRID2,HCN1,GRIA3,DPP10,DLG3,CACNA1A,KCNC1,GRIN1,SCN8A,GRIK2,GABRB2,KCNIP2
4.402e-20	-44.57	transporter complex	cellular component	GO:1990351	461	20	19108	49	SCN8A,GRIN1,KCNIP2,GABRB2,GRIK2,CACNA1A,DLG3,KCNC1,GRIA3,DPP10,GRID2,GABRD,HCN1,GRIN2B,CACNA1G,CACNA1H,DLG4,STXBP5,GABRA1,KCNMA1
1.503e-18	-41.04	postsynapse	cellular component	GO:0098794	646	21	19108	49	KCNC1,CHRM2,GRM7,GPHN,DLG3,GABRB2,GRIK2,GRIN1,SCN8A,CELF4,GRIA3,GRIN2B,GABBR2,HCN1,GRID2,GABRD,KCNMA1,GABRA1,KCTD16,ASIC2,DLG4
2.558e-18	-40.51	Neuronal System	REACTOME pathways	R-HSA-112316	349	17	10285	29	GABRB2,GABRA1,GRIK2,KCNC1,GRIN2B,GABBR2,SYT1,GRIA3,DLG4,GRIN1,KCNMA1,HCN1,SYT7,CACNA1A,NRXN2,NRXN1,DLG3
2.741e-18	-40.44	gated channel activity	molecular function	GO:0022836	320	17	18094	48	GRIN1,KCNIP2,GRIN2B,HCN1,ASIC2,KCNMA1,KCNC1,CACNA1G,GABRB2,CACNA1H,KCNT1,GRIK2,GRID2,CACNA1A,GABRD,GABRA1,GRIA3
2.943e-18	-40.37	plasma membrane region	cellular component	GO:0098590	1278	26	19108	49	GABRB2,PDE2A,KCNC1,DLG3,GPHN,GRM7,NRXN1,GRIA3,SYT7,HCN1,GABRD,GRIN2B,KCTD16,DLG4,KCNMA1,GRIK2,SCN8A,CNTN5,GRIN1,CHRM2,NRXN2,GRID2,RIMS2,GABBR2,SYT1,GABRA1
2.438e-17	-38.25	monoatomic ion channel activity	molecular function	GO:0005216	441	18	18094	48	KCNT1,GRIK2,GRID2,GABRD,CACNA1A,GABRA1,GRIA3,KCNIP2,GRIN1,GRIN2B,ASIC2,HCN1,KCNMA1,KCNC1,CACNA1G,CACNA1H,GABRB2,SCN8A
6.164e-17	-37.33	presynapse	cellular component	GO:0098793	569	19	19108	49	HCN1,MCTP1,SYT7,RIMS2,STXBP5,KCTD16,DLG4,SYT1,GRIK2,CNTN5,SCN8A,GRIN1,PDE2A,KCNC1,CADPS,CHRM2,NRXN1,GRM7,NRXN2
1.186e-16	-36.67	neuron projection	cellular component	GO:0043005	1331	25	19108	49	GRIA3,TENM1,GABRB2,GPHN,GRM7,DLG3,KCNC1,ASIC2,DLG4,NTRK3,GABRD,HCN1,SYT7,GRIN2B,GRIN1,SCN8A,CNTN5,KCNIP2,OLFM1,GRIK2,CHRM2,GABRA1,SYT1,GRID2,GABBR2
2.340e-16	-35.99	presynaptic membrane	cellular component	GO:0042734	168	13	19108	49	KCTD16,SYT1,HCN1,SYT7,RIMS2,NRXN2,CNTN5,SCN8A,PDE2A,GRIK2,NRXN1,KCNC1,CHRM2
2.377e-16	-35.98	channel activity	molecular function	GO:0015267	502	18	18094	48	ASIC2,HCN1,GRIN2B,KCNIP2,GRIN1,CACNA1H,SCN8A,GABRB2,KCNC1,CACNA1G,KCNMA1,KCNT1,GRIK2,GRIA3,GABRA1,GABRD,CACNA1A,GRID2
2.461e-16	-35.94	passive transmembrane transporter activity	molecular function	GO:0022803	503	18	18094	48	GABRA1,GRIA3,GRID2,GABRD,CACNA1A,GRIK2,KCNT1,KCNC1,CACNA1G,CACNA1H,GABRB2,SCN8A,KCNMA1,GRIN2B,ASIC2,HCN1,KCNIP2,GRIN1
1.289e-15	-34.28	cell projection	cellular component	GO:0042995	2398	30	19108	49	CHRM2,OLFM1,GRIK2,KCNIP2,GRIN1,SCN8A,CNTN5,NRXN2,RIMS2,GABBR2,GRID2,SYT1,GABRA1,KCNC1,DLG3,GPHN,GRM7,CACNA1A,NRXN1,GABRB2,TENM1,GRIA3,GRIN2B,SYT7,HCN1,GABRD,NTRK3,KCTD16,DLG4,ASIC2
2.313e-15	-33.70	modulation of chemical synaptic transmission	biological process	GO:0050804	494	17	18204	47	CHRM2,GRIN2B,MCTP1,DLG4,GRM7,CACNA1A,CELF4,SYT7,GRIN1,GRIA3,NRXN1,GRID2,NRG3,SYT1,STXBP5,RIMS2,GRIK2
2.391e-15	-33.67	regulation of trans-synaptic signaling	biological process	GO:0099177	495	17	18204	47	CELF4,GRM7,CACNA1A,SYT7,GRIN1,GRIN2B,CHRM2,DLG4,MCTP1,STXBP5,RIMS2,GRIK2,NRXN1,GRIA3,NRG3,GRID2,SYT1
2.549e-15	-33.60	receptor complex	cellular component	GO:0043235	409	16	19108	49	GABRA1,DLG4,KCTD16,STXBP5,GABBR2,GRIN2B,GABRD,GRID2,ALK,NTRK3,GRIA3,DLG3,GRM7,GRIN1,GRIK2,GABRB2
3.198e-15	-33.38	plasma membrane protein complex	cellular component	GO:0098797	600	18	19108	49	SCN8A,GRIN1,GRIK2,KCNIP2,DLG3,CACNA1A,KCNC1,GRIA3,DPP10,GRID2,HCN1,GABBR2,CACNA1G,GRIN2B,DLG4,CACNA1H,STXBP5,KCNMA1
2.916e-14	-31.17	plasma membrane	cellular component	GO:0005886	5538	40	19108	49	CSMD2,GRIN2B,NTRK3,GABRD,HCN1,KCNT1,SYT7,KCNMA1,DLG4,ASIC2,KCTD16,GPHN,NRXN1,GRM7,CACNA1A,DLG3,KCNC1,PDE2A,GABRB2,GRIA3,TENM1,DPP10,GABBR2,RIMS2,CACNA1G,GRID2,ALK,GABRA1,SYT1,CACNA1H,STXBP5,CHRM2,GRIN1,SCN8A,CNTN5,KCNIP2,GRIK2,GPR85,NRXN2,NRG3
3.207e-14	-31.07	-	gene3d domains	1.10.287.70	148	12	14470	47	GRIN1,HCN1,KCNMA1,KCNT1,SCN8A,GRIK2,GRID2,CACNA1H,CACNA1G,KCNC1,CACNA1A,GRIA3
4.915e-14	-30.64	ligand-gated monoatomic ion channel activity	molecular function	GO:0015276	186	12	18094	48	GRIK2,KCNT1,GRID2,GABRD,GABRA1,GRIA3,GRIN1,GRIN2B,ASIC2,HCN1,KCNMA1,GABRB2
5.242e-14	-30.58	ligand-gated channel activity	molecular function	GO:0022834	187	12	18094	48	GRIN1,GRIK2,KCNT1,GRIN2B,ASIC2,HCN1,GRID2,KCNMA1,GABRD,GABRA1,GABRB2,GRIA3
1.257e-13	-29.71	regulation of postsynaptic membrane potential	biological process	GO:0060078	106	10	18204	47	HCN1,GRID2,GRIN2B,GRIA3,GRIN1,GRIK2,GABRB2,GABRD,GABRA1,CELF4
2.158e-13	-29.16	Protein-protein interactions at synapses	REACTOME pathways	R-HSA-6794362	72	9	10285	29	GRIN1,DLG4,GRIA3,SYT1,NRXN1,DLG3,NRXN2,SYT7,GRIN2B
2.478e-13	-29.03	neuron to neuron synapse	cellular component	GO:0098984	365	14	19108	49	GRIA3,GRM7,GPHN,DLG3,CHRM2,SCN8A,GRIN1,GRIK2,SYT1,DLG4,STXBP5,GRIN2B,GRID2,SYT7
2.536e-13	-29.00	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	18	18094	48	KCNT1,GRIK2,GABRA1,GRIA3,GRID2,GABRD,CACNA1A,GRIN2B,ASIC2,HCN1,KCNIP2,GRIN1,CACNA1G,KCNC1,CACNA1H,SCN8A,GABRB2,KCNMA1
4.632e-13	-28.40	monoatomic ion transmembrane transport	biological process	GO:0034220	804	18	18204	47	GRIN2B,CACNA1G,SCN8A,CACNA1A,ASIC2,CACNA1H,GABRD,GRIN1,KCNIP2,GRIA3,KCNC1,GRID2,HCN1,KCNT1,KCNMA1,GABRA1,GABRB2,GRIK2
6.071e-13	-28.13	cell periphery	cellular component	GO:0071944	6020	40	19108	49	GPR85,NRXN2,NRG3,CHRM2,CNTN5,SCN8A,GRIN1,KCNIP2,GRIK2,GABRA1,SYT1,CACNA1H,STXBP5,GABBR2,CACNA1G,RIMS2,ALK,GRID2,GRIA3,TENM1,DPP10,NRXN1,GPHN,GRM7,CACNA1A,DLG3,KCNC1,PDE2A,GABRB2,KCNMA1,ASIC2,DLG4,KCTD16,CSMD2,GRIN2B,NTRK3,GABRD,HCN1,SYT7,KCNT1
9.030e-13	-27.73	membrane protein complex	cellular component	GO:0098796	1261	21	19108	49	CACNA1G,GRIN2B,GABBR2,HCN1,GRID2,GABRD,KCNMA1,GABRA1,STXBP5,CACNA1H,DLG4,KCNC1,CACNA1A,DLG3,GABRB2,KCNIP2,GRIK2,GRIN1,SCN8A,DPP10,GRIA3
1.526e-12	-27.21	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	17	18094	48	KCNMA1,GABRB2,SCN8A,CACNA1H,KCNC1,CACNA1G,GRIN1,KCNIP2,HCN1,ASIC2,GRIN2B,CACNA1A,GABRD,GRIA3,GABRA1,KCNT1,GRIK2
2.081e-12	-26.90	regulation of biological quality	biological process	GO:0065008	2936	29	18204	47	NRXN1,HCN1,OLFM1,GPHN,KCNMA1,GRIK2,DLG4,FGF12,CELF4,SYT7,GRIN1,CACNA1H,GRIA3,KCNC1,GRID2,KCNIP2,PDE2A,RIMS2,DLG3,GABRA1,GABRB2,GRIN2B,SCN8A,CACNA1G,MCTP1,TENM1,ASIC2,CACNA1A,GABRD
2.204e-12	-26.84	monoatomic cation channel activity	molecular function	GO:0005261	331	13	18094	48	KCNT1,GRIN2B,GRIK2,ASIC2,HCN1,KCNIP2,GRIN1,KCNC1,CACNA1G,CACNA1H,SCN8A,KCNMA1,CACNA1A
2.425e-12	-26.75	Interactions of neurexins and neuroligins at synapses	REACTOME pathways	R-HSA-6794361	58	8	10285	29	GRIN1,DLG4,NRXN1,DLG3,SYT1,SYT7,NRXN2,GRIN2B
2.660e-12	-26.65	transmitter-gated monoatomic ion channel activity	molecular function	GO:0022824	59	8	18094	48	GRIN1,GRIN2B,GRIK2,GRID2,GABRD,GABRA1,GABRB2,GRIA3
2.660e-12	-26.65	transmitter-gated channel activity	molecular function	GO:0022835	59	8	18094	48	GRIN1,GRIN2B,GRIK2,GRID2,GABRD,GABRA1,GABRB2,GRIA3
3.378e-12	-26.41	cation channel complex	cellular component	GO:0034703	205	11	19108	49	KCNMA1,DPP10,DLG4,CACNA1H,CACNA1A,CACNA1G,KCNC1,SCN8A,GRIK2,KCNIP2,HCN1
3.533e-12	-26.37	neurotransmitter receptor activity	molecular function	GO:0030594	97	9	18094	48	GRIN1,CHRM2,GRIK2,GRIN2B,GABRD,GRID2,GABRB2,GRIA3,GABRA1
6.530e-12	-25.75	ANF_lig-bd_rcpt	interpro domains	IPR001828	37	7	18521	50	GRIN1,GRID2,GRM7,GRIK2,GABBR2,GRIA3,GRIN2B
7.101e-12	-25.67	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	11	10285	29	GRIN1,GRIK2,GABRB2,GRIA3,DLG4,GABRA1,DLG3,SYT1,GRIN2B,GABBR2,CACNA1A
7.422e-12	-25.63	ANF_receptor	pfam domains	PF01094	37	7	17795	49	GRM7,GRIN2B,GABBR2,GRIN1,GRIK2,GRIA3,GRID2
9.716e-12	-25.36	Peripla_BP_I	interpro domains	IPR028082	39	7	18521	50	GRID2,GRIN1,GABBR2,GRIK2,GRM7,GRIN2B,GRIA3
9.748e-12	-25.35	monoatomic ion transport	biological process	GO:0006811	964	18	18204	47	GRID2,GRIA3,KCNC1,KCNIP2,HCN1,KCNMA1,KCNT1,GRIK2,GABRB2,GABRA1,CACNA1G,SCN8A,GRIN2B,CACNA1A,ASIC2,GRIN1,GABRD,CACNA1H
9.813e-12	-25.35	ionotropic glutamate receptor complex	cellular component	GO:0008328	41	7	19108	49	GRIK2,DLG4,GRID2,GRIN1,GRIN2B,DLG3,GRIA3
1.108e-11	-25.23	postsynaptic neurotransmitter receptor activity	molecular function	GO:0098960	70	8	18094	48	CHRM2,GRIN2B,GRIK2,GRIA3,GABRB2,GABRA1,GABRD,GRID2
1.308e-11	-25.06	somatodendritic compartment	cellular component	GO:0036477	842	17	19108	49	NRXN1,GPHN,GRM7,CACNA1A,KCNC1,CHRM2,GRIN1,KCNIP2,GRIK2,OLFM1,GRIA3,GRID2,GABRD,HCN1,GABRA1,ASIC2,DLG4
1.400e-11	-24.99	extracellular ligand-gated monoatomic ion channel activity	molecular function	GO:0005230	72	8	18094	48	GRID2,GABRD,GABRA1,GRIA3,GABRB2,GRIN1,GRIN2B,GRIK2
2.093e-11	-24.59	voltage-gated monoatomic ion channel activity	molecular function	GO:0005244	171	10	18094	48	HCN1,KCNT1,GRIN2B,KCNIP2,GRIN1,CACNA1H,CACNA1G,KCNC1,CACNA1A,KCNMA1
2.314e-11	-24.49	neurotransmitter receptor complex	cellular component	GO:0098878	46	7	19108	49	GRIK2,GRIN1,GRID2,DLG4,GRIN2B,GRIA3,DLG3
2.350e-11	-24.47	voltage-gated channel activity	molecular function	GO:0022832	173	10	18094	48	KCNT1,GRIN2B,HCN1,GRIN1,KCNIP2,CACNA1G,KCNC1,CACNA1H,KCNMA1,CACNA1A
2.701e-11	-24.33	postsynaptic specialization membrane	cellular component	GO:0099634	125	9	19108	49	DLG4,GRIA3,GRIK2,GABRB2,GRID2,SCN8A,GRIN2B,DLG3,GPHN
2.719e-11	-24.33	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	25	19108	49	ASIC2,DLG4,GRIN2B,HCN1,SYT7,NTRK3,GABRD,TENM1,GRIA3,KCNC1,GRM7,GPHN,DLG3,GABRB2,SYT1,GABRA1,GABBR2,GRID2,CHRM2,KCNIP2,OLFM1,GRIK2,CNTN5,SCN8A,GRIN1
2.874e-11	-24.27	cell communication	biological process	GO:0007154	5010	35	18204	47	GABBR2,FGF12,DLG4,ALK,CHRM2,CADPS,GRIN1,SYT7,GRM7,CELF4,SYT1,NRXN2,HCN1,NRG3,NRXN1,GRIK2,OLFM1,GPR85,MCTP1,SCN8A,CACNA1G,GRIN2B,GABRD,ASIC2,CACNA1A,TENM1,KCNIP2,NTRK3,GRID2,GRIA3,GABRB2,GABRA1,RIMS2,DLG3,PDE2A
3.795e-11	-23.99	modulation of excitatory postsynaptic potential	biological process	GO:0098815	49	7	18204	47	GRIK2,GRIN1,CELF4,RIMS2,DLG4,GRIN2B,NRXN1
5.575e-11	-23.61	glutamate receptor activity	molecular function	GO:0008066	26	6	18094	48	GRIK2,GRIN2B,GRIN1,GRM7,GRIA3,GRID2
8.207e-11	-23.22	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	13	18094	48	CACNA1H,SCN8A,CACNA1G,KCNC1,CACNA1A,KCNMA1,ASIC2,HCN1,KCNT1,GRIK2,GRIN2B,KCNIP2,GRIN1
8.232e-11	-23.22	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	molecular function	GO:1904315	53	7	18094	48	GRIN2B,GRIK2,GRIA3,GABRB2,GABRA1,GABRD,GRID2
1.004e-10	-23.02	regulation of system process	biological process	GO:0044057	571	14	18204	47	CACNA1G,CHRM2,GRIN2B,DLG4,FGF12,CELF2,CELF4,ASIC2,GRIN1,CACNA1H,NRXN1,KCNIP2,RIMS2,GRIK2
1.061e-10	-22.97	Nicotine addiction	KEGG pathways	ko05033	40	7	7161	28	GRIN1,GABRD,GRIN2B,GABRB2,CACNA1A,GABRA1,GRIA3
1.061e-10	-22.97	Nicotine addiction	KEGG pathways	hsa05033	40	7	7161	28	GRIA3,GABRA1,CACNA1A,GABRB2,GRIN2B,GABRD,GRIN1
1.079e-10	-22.95	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	molecular function	GO:0099529	55	7	18094	48	GRID2,GABRD,GABRA1,GABRB2,GRIA3,GRIN2B,GRIK2
1.437e-10	-22.66	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME pathways	R-HSA-112314	146	9	10285	29	GRIN1,GRIK2,GABRB2,GRIA3,DLG4,GABRA1,DLG3,GRIN2B,GABBR2
1.646e-10	-22.53	inorganic ion transmembrane transport	biological process	GO:0098660	715	15	18204	47	GRIN2B,SCN8A,CACNA1G,CACNA1A,ASIC2,GRIN1,CACNA1H,GABRD,KCNC1,KCNIP2,HCN1,KCNT1,KCNMA1,GABRA1,GABRB2
1.664e-10	-22.52	transmembrane transporter activity	molecular function	GO:0022857	1110	18	18094	48	GRID2,GABRD,CACNA1A,GABRA1,GRIA3,GRIK2,KCNT1,KCNMA1,CACNA1G,KCNC1,CACNA1H,GABRB2,SCN8A,KCNIP2,GRIN1,GRIN2B,ASIC2,HCN1
2.151e-10	-22.26	-	gene3d domains	3.40.50.2300	50	7	14470	47	GRIN1,GRIN2B,GRM7,GRID2,GRIK2,GRIA3,GABBR2
2.238e-10	-22.22	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	14	18094	48	ASIC2,HCN1,GRIN2B,KCNIP2,GRIN1,CACNA1H,SCN8A,CACNA1G,KCNC1,KCNMA1,KCNT1,GRIK2,GRIA3,CACNA1A
2.934e-10	-21.95	dendrite	cellular component	GO:0030425	620	14	19108	49	ASIC2,DLG4,GABRA1,HCN1,GRID2,GABRD,GRIA3,KCNIP2,GRIK2,GRIN1,KCNC1,CHRM2,GRM7,GPHN
3.060e-10	-21.91	dendritic tree	cellular component	GO:0097447	622	14	19108	49	HCN1,GABRD,GRID2,ASIC2,DLG4,GABRA1,GRIK2,KCNIP2,GRIN1,CHRM2,KCNC1,GPHN,GRM7,GRIA3
4.542e-10	-21.51	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	30	16828	48	FGF12,CNTN5,KCNMA1,CACNA1G,CELF5,GABRB2,NRXN2,SYT7,RIMS2,CACNA1H,GRIA3,RALYL,CELF4,GRIN1,HCN1,SCN8A,TENM1,ALK,PDE2A,MCTP1,KCNC1,CADPS,NRG3,CACNA1A,SYT1,CSMD2,GRM7,STXBP5,GRID2,NTRK3
4.542e-10	-21.51	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	30	16828	48	STXBP5,GRM7,CSMD2,SYT1,CACNA1A,NTRK3,GRID2,PDE2A,ALK,TENM1,SCN8A,HCN1,NRG3,CADPS,KCNC1,MCTP1,CACNA1H,RIMS2,CELF4,GRIN1,RALYL,GRIA3,GABRB2,CELF5,KCNMA1,CACNA1G,FGF12,CNTN5,SYT7,NRXN2
5.431e-10	-21.33	axon	cellular component	GO:0030424	650	14	19108	49	KCNC1,CHRM2,GRM7,OLFM1,GRIK2,GRIN1,CNTN5,SCN8A,HCN1,SYT7,NTRK3,GABRD,SYT1,DLG4
6.165e-10	-21.21	asymmetric synapse	cellular component	GO:0032279	333	11	19108	49	GRIA3,CHRM2,DLG3,GRM7,GPHN,GRIK2,SCN8A,GRIN1,DLG4,GRIN2B,GRID2
6.243e-10	-21.19	synapse assembly	biological process	GO:0007416	118	8	18204	47	ASIC2,GABRA1,GABRB2,NRXN1,NRG3,GRID2,NRXN2,CNTN5
6.824e-10	-21.11	transporter activity	molecular function	GO:0005215	1211	18	18094	48	GRIN2B,ASIC2,HCN1,KCNIP2,GRIN1,CACNA1G,KCNC1,CACNA1H,GABRB2,SCN8A,KCNMA1,GRIK2,KCNT1,GABRA1,GRIA3,GRID2,CACNA1A,GABRD
7.144e-10	-21.06	regulation of nervous system process	biological process	GO:0031644	120	8	18204	47	GRIK2,GRIN1,CELF4,RIMS2,DLG4,FGF12,NRXN1,GRIN2B
8.236e-10	-20.92	transmembrane transport	biological process	GO:0055085	1264	18	18204	47	GRIK2,GABRA1,GABRB2,KCNT1,KCNMA1,HCN1,GRIA3,KCNC1,GRID2,KCNIP2,GRIN1,CACNA1H,GABRD,ASIC2,CACNA1A,GRIN2B,CACNA1G,SCN8A
9.741e-10	-20.75	Iontro_rcpt_C	interpro domains	IPR001320	18	5	18521	50	GRIN1,GRIA3,GRID2,GRIN2B,GRIK2
9.741e-10	-20.75	Ionotropic_Glu_rcpt	interpro domains	IPR015683	18	5	18521	50	GRIK2,GRIA3,GRIN1,GRID2,GRIN2B
9.741e-10	-20.75	Glu/Gly-bd	interpro domains	IPR019594	18	5	18521	50	GRIA3,GRIN1,GRIN2B,GRID2,GRIK2
9.741e-10	-20.75	Iono_Glu_rcpt_met	interpro domains	IPR001508	18	5	18521	50	GRIK2,GRIA3,GRIN1,GRID2,GRIN2B
1.070e-09	-20.66	Lig_chan-Glu_bd	pfam domains	PF10613	18	5	17795	49	GRIN2B,GRIK2,GRIA3,GRIN1,GRID2
1.070e-09	-20.66	Lig_chan	pfam domains	PF00060	18	5	17795	49	GRIA3,GRIN1,GRIK2,GRID2,GRIN2B
1.076e-09	-20.65	signaling	biological process	GO:0023052	4968	33	18204	47	GRIK2,OLFM1,GPR85,SYT1,NRXN2,NRG3,NRXN1,GRIN1,SYT7,GRM7,CELF4,GABBR2,FGF12,DLG4,ALK,CADPS,CHRM2,GABRB2,GABRA1,DLG3,RIMS2,PDE2A,KCNIP2,NTRK3,GRID2,GRIA3,GABRD,ASIC2,CACNA1A,TENM1,MCTP1,CACNA1G,GRIN2B
1.200e-09	-20.54	plasma membrane signaling receptor complex	cellular component	GO:0098802	191	9	19108	49	GRIK2,GRID2,GRIN1,GRIN2B,GABBR2,DLG3,STXBP5,DLG4,GRIA3
1.606e-09	-20.25	glutamate receptor signaling pathway	biological process	GO:0007215	45	6	18204	47	GRID2,GRIA3,GRIN2B,GRM7,GRIN1,GRIK2
1.687e-09	-20.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	15	16828	48	ALK,PDE2A,HCN1,NRG3,SYT7,GABBR2,MCTP1,GRM7,OLFM1,SYT1,GRIN2B,CSMD2,RALYL,GRID2,CELF4
1.843e-09	-20.11	receptor clustering	biological process	GO:0043113	46	6	18204	47	NRXN2,DLG4,GRIK2,DLG3,GPHN,NRXN1
2.445e-09	-19.83	SALM protein interactions at the synapses	REACTOME pathways	R-HSA-8849932	21	5	10285	29	GRIN1,DLG3,DLG4,GRIN2B,GRIA3
2.741e-09	-19.71	Neuroactive ligand-receptor interaction	KEGG pathways	hsa04080	276	11	7161	28	GRM7,GABRA1,GABRD,GRID2,GRIK2,GRIA3,CHRM2,GRIN1,GABRB2,GABBR2,GRIN2B
2.741e-09	-19.71	Neuroactive ligand-receptor interaction	KEGG pathways	ko04080	276	11	7161	28	GRIN1,GRIN2B,GABBR2,GABRB2,GRID2,CHRM2,GRIA3,GRIK2,GABRD,GRM7,GABRA1
3.612e-09	-19.44	voltage-gated monoatomic cation channel activity	molecular function	GO:0022843	143	8	18094	48	KCNMA1,CACNA1A,KCNC1,CACNA1G,CACNA1H,KCNIP2,KCNT1,HCN1
3.689e-09	-19.42	nervous system development	biological process	GO:0007399	2185	22	18204	47	GABRA1,GABRB2,OLFM1,HCN1,NRXN2,NTRK3,KCNIP2,KCNC1,NRXN1,NRG3,GRID2,GRIN1,GRM7,ASIC2,TENM1,FGF12,CNTN5,DLG4,ALK,GRIN2B,CHRM2,SCN8A
4.327e-09	-19.26	PBPe	smart domains	SM00079	18	5	9717	36	GRIN1,GRIA3,GRIN2B,GRID2,GRIK2
4.327e-09	-19.26	Lig_chan-Glu_bd	smart domains	SM00918	18	5	9717	36	GRIA3,GRIN2B,GRIK2,GRID2,GRIN1
5.722e-09	-18.98	glutamatergic synapse	cellular component	GO:0098978	412	11	19108	49	CADPS,CHRM2,DLG3,GRIK2,SCN8A,NRXN2,NRG3,HCN1,GRID2,SYT1,DLG4
6.141e-09	-18.91	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	13	18094	48	GRIK2,KCNT1,CACNA1A,KCNIP2,GRIN1,GRIN2B,ASIC2,HCN1,KCNMA1,CACNA1G,KCNC1,CACNA1H,SCN8A
6.687e-09	-18.82	potassium channel complex	cellular component	GO:0034705	101	7	19108	49	DLG4,HCN1,KCNIP2,GRIK2,KCNMA1,KCNC1,DPP10
6.687e-09	-18.82	postsynaptic density membrane	cellular component	GO:0098839	101	7	19108	49	GRIA3,DLG3,GRIN2B,GRID2,SCN8A,DLG4,GRIK2
7.259e-09	-18.74	membrane	cellular component	GO:0016020	9220	43	19108	49	GRID2,ALK,GABBR2,RIMS2,CACNA1G,CACNA1H,STXBP5,GABRA1,SYT1,SCN8A,GRIN1,CNTN5,KCNIP2,GRIK2,CADPS,CHRM2,NRG3,GPR85,NRXN2,NTRK3,GABRD,HCN1,MCTP1,KCNT1,SYT7,CSMD2,GRIN2B,DLG4,ASIC2,KCTD16,KCNMA1,PDE2A,GABRB2,NRXN1,GRM7,CACNA1A,GPHN,DLG3,KCNC1,CSMD1,GRIA3,TENM1,DPP10
9.354e-09	-18.49	Periplasmic binding protein-like II	gene3d domains	3.40.190.10	23	5	14470	47	GRIN1,GRIK2,GRIN2B,GRID2,GRIA3
1.042e-08	-18.38	synapse organization	biological process	GO:0050808	333	10	18204	47	GABRB2,GABRA1,GPHN,ASIC2,NRXN2,DLG4,CNTN5,NRG3,GRID2,NRXN1
1.422e-08	-18.07	postsynaptic specialization	cellular component	GO:0099572	345	10	19108	49	DLG4,GRIA3,GRIK2,GABRB2,GRID2,GRIN1,SCN8A,GRIN2B,DLG3,GPHN
1.526e-08	-18.00	excitatory synapse	cellular component	GO:0060076	65	6	19108	49	DLG4,GRIA3,SYT1,GRIN1,SCN8A,GRID2
1.632e-08	-17.93	Ion_trans_dom	interpro domains	IPR005821	109	7	18521	50	KCNC1,CACNA1H,CACNA1G,HCN1,SCN8A,CACNA1A,KCNMA1
1.761e-08	-17.85	positive regulation of excitatory postsynaptic potential	biological process	GO:2000463	32	5	18204	47	RIMS2,NRXN1,GRIN2B,DLG4,GRIN1
1.851e-08	-17.81	Ion_trans	pfam domains	PF00520	109	7	17795	49	KCNC1,CACNA1G,SCN8A,KCNMA1,HCN1,CACNA1H,CACNA1A
2.213e-08	-17.63	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	13	16828	48	GRIA3,CELF4,GRID2,RALYL,CELF2,GRM7,NRXN1,MCTP1,NRG3,SYT7,DPP10,FGF12,SCN8A
2.254e-08	-17.61	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	13	16828	48	SCN8A,FGF12,MCTP1,NRXN1,DPP10,NRG3,SYT7,GRM7,CELF2,GRIA3,RALYL,GRID2,CELF4
2.878e-08	-17.36	action potential	biological process	GO:0001508	124	7	18204	47	GRIK2,HCN1,FGF12,KCNC1,SCN8A,CACNA1G,KCNIP2
3.510e-08	-17.17	system process	biological process	GO:0003008	2015	20	18204	47	FGF12,CNTN5,DLG4,GRIN2B,SCN8A,CACNA1G,CACNA1H,GRIN1,GRM7,CSMD1,ASIC2,CELF4,HCN1,NRXN2,KCNIP2,NRXN1,GRID2,GRIK2,KCNMA1,PDE2A
3.572e-08	-17.15	NMDARECEPTOR	prints domains	PR00177	18	5	5227	30	GRIA3,GRIN1,GRIK2,GRID2,GRIN2B
3.710e-08	-17.11	inorganic cation transmembrane transport	biological process	GO:0098662	618	12	18204	47	GRIN2B,CACNA1G,SCN8A,ASIC2,CACNA1A,CACNA1H,GRIN1,KCNIP2,KCNC1,HCN1,KCNT1,KCNMA1
4.394e-08	-16.94	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	6	18204	47	NRXN1,GRIN2B,GRM7,GRIK2,GRIN1,SYT1
4.581e-08	-16.90	metal ion transport	biological process	GO:0030001	630	12	18204	47	KCNC1,KCNIP2,HCN1,KCNT1,KCNMA1,GRIN2B,SCN8A,CACNA1G,CACNA1A,ASIC2,GRIN1,CACNA1H
5.082e-08	-16.79	monoatomic cation transmembrane transport	biological process	GO:0098655	636	12	18204	47	KCNT1,KCNMA1,KCNIP2,KCNC1,HCN1,CACNA1A,ASIC2,CACNA1H,GRIN1,GRIN2B,CACNA1G,SCN8A
6.280e-08	-16.58	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	7	18094	48	KCNMA1,GRIN1,KCNT1,GRIN2B,GRIK2,ASIC2,HCN1
7.138e-08	-16.46	localization	biological process	GO:0051179	4474	29	18204	47	GABRD,ASIC2,CACNA1A,CACNA1G,SCN8A,GRIN2B,GABRB2,GABRA1,RIMS2,DLG3,STXBP5,KCNIP2,GRID2,KCNC1,GRIA3,CACNA1H,GRIN1,SYT7,DPP10,DLG4,CADPS,GRIK2,KCNMA1,KCNT1,GPHN,SYT1,NRXN2,HCN1,NRXN1
7.749e-08	-16.37	glutamate-gated receptor activity	molecular function	GO:0004970	16	4	18094	48	GRIA3,GRIN2B,GRIK2,GRIN1
7.820e-08	-16.36	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	18	16828	48	GRID2,CELF4,RALYL,KCTD16,GRM7,CSMD2,SYT1,GRIN2B,NRG3,SYT7,MCTP1,KCNIP2,PDE2A,ALK,CACNA1G,FGF12,CNTN5,HCN1
7.820e-08	-16.36	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	18	16828	48	NRG3,SYT7,KCNIP2,MCTP1,ALK,PDE2A,CACNA1G,CNTN5,HCN1,FGF12,RALYL,GRID2,CELF4,KCTD16,GRM7,SYT1,GRIN2B,CSMD2
8.111e-08	-16.33	regulation of synaptic plasticity	biological process	GO:0048167	219	8	18204	47	GRID2,GRIN2B,DLG4,MCTP1,RIMS2,GRIN1,SYT7,GRIK2
9.748e-08	-16.14	postsynaptic density	cellular component	GO:0014069	317	9	19108	49	GRIK2,GRIN1,GRID2,SCN8A,GRIN2B,DLG3,GPHN,DLG4,GRIA3
9.833e-08	-16.13	signal release from synapse	biological process	GO:0099643	88	6	18204	47	SYT1,SYT7,NRXN2,RIMS2,NRXN1,CADPS
9.833e-08	-16.13	neurotransmitter secretion	biological process	GO:0007269	88	6	18204	47	SYT7,NRXN2,SYT1,NRXN1,CADPS,RIMS2
1.059e-07	-16.06	GRIK5 (glutamate ionotropic receptor kainate type subunit 5)	protein interactions	2901	18	4	19454	49	GRID2,DLG3,GRIK2,DLG4
1.096e-07	-16.03	voltage-gated potassium channel complex	cellular component	GO:0008076	90	6	19108	49	KCNIP2,HCN1,KCNC1,DLG4,KCNMA1,DPP10
1.096e-07	-16.03	multicellular organism development	biological process	GO:0007275	3957	27	18204	47	HCN1,NRXN2,NRXN1,NRG3,OLFM1,FGF12,DLG4,ALK,CHRM2,GRIN1,GRM7,CELF4,NTRK3,KCNIP2,KCNC1,GRID2,GABRA1,GABRB2,DLG3,PDE2A,CNTN5,GRIN2B,CACNA1G,SCN8A,ASIC2,CSMD1,TENM1
1.127e-07	-16.00	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	28	16828	48	CSMD2,GRIN2B,SYT1,GRM7,KCNT1,GRID2,NTRK3,TENM1,HCN1,SCN8A,PDE2A,ALK,KCNC1,MCTP1,NRG3,RIMS2,OLFM1,CACNA1H,GRIA3,KCTD16,GRIN1,CELF4,CNTN5,FGF12,CACNA1G,CHRM2,NRXN1,GABBR2
1.127e-07	-16.00	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	28	16828	48	NRXN1,GABBR2,CACNA1G,CNTN5,FGF12,CHRM2,GRIA3,KCTD16,GRIN1,CELF4,RIMS2,CACNA1H,OLFM1,KCNC1,MCTP1,NRG3,TENM1,SCN8A,HCN1,PDE2A,ALK,KCNT1,GRID2,NTRK3,CSMD2,SYT1,GRIN2B,GRM7
1.183e-07	-15.95	Unblocking of NMDA receptor, glutamate binding and activation	REACTOME pathways	R-HSA-438066	17	4	10285	29	DLG4,GRIA3,GRIN2B,GRIN1
1.339e-07	-15.83	NLGN1 (neuroligin 1)	protein interactions	22871	19	4	19454	49	DLG3,NRXN2,NRXN1,DLG4
1.461e-07	-15.74	positive regulation of synaptic transmission	biological process	GO:0050806	157	7	18204	47	GRIK2,GRIN1,RIMS2,SYT1,DLG4,GRIN2B,NRXN1
1.498e-07	-15.71	cerebellum	COSMIC cancer mutations	cerebellum	769	13	16828	48	GRID2,CELF4,RALYL,GRIA3,CELF2,GRM7,NRG3,SYT7,DPP10,NRXN1,MCTP1,SCN8A,FGF12
1.746e-07	-15.56	neuroligin family protein binding	molecular function	GO:0097109	5	3	18094	48	NRXN1,DLG4,NRXN2
1.762e-07	-15.55	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	34	16828	48	FGF12,CNTN5,KCNMA1,GPR85,CACNA1G,GABRB2,NRXN2,SYT7,DPP10,RIMS2,OLFM1,CACNA1H,GRIA3,KCTD16,GRIK2,CELF4,GRIN1,HCN1,SCN8A,PDE2A,ALK,KCNC1,MCTP1,CADPS,NRG3,GABRA1,CSMD2,CACNA1A,GRIN2B,STXBP5,GRM7,KCNT1,GRID2,NTRK3
1.762e-07	-15.55	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	34	16828	48	GABRB2,KCNMA1,CACNA1G,GPR85,CNTN5,FGF12,SYT7,DPP10,NRXN2,CACNA1H,OLFM1,RIMS2,GRIK2,CELF4,GRIN1,GRIA3,KCTD16,PDE2A,ALK,SCN8A,HCN1,CADPS,GABRA1,NRG3,KCNC1,MCTP1,STXBP5,GRM7,CSMD2,GRIN2B,CACNA1A,NTRK3,GRID2,KCNT1
1.934e-07	-15.46	Glutamatergic synapse	KEGG pathways	hsa04724	114	7	7161	28	GRM7,GRIA3,GRIK2,GRIN1,CACNA1A,GRIN2B,DLG4
1.934e-07	-15.46	Glutamatergic synapse	KEGG pathways	ko04724	114	7	7161	28	GRIN1,CACNA1A,DLG4,GRIN2B,GRM7,GRIK2,GRIA3
2.212e-07	-15.32	GABA receptor complex	cellular component	GO:1902710	21	4	19108	49	GABRD,GABRB2,GABBR2,GABRA1
2.440e-07	-15.23	system development	biological process	GO:0048731	3533	25	18204	47	GRM7,GRIN1,ALK,CHRM2,FGF12,DLG4,OLFM1,NRXN1,NRG3,HCN1,NRXN2,CSMD1,ASIC2,TENM1,GRIN2B,CACNA1G,SCN8A,CNTN5,PDE2A,GABRA1,GABRB2,NTRK3,KCNIP2,KCNC1,GRID2
3.016e-07	-15.01	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	36	16828	48	NRXN1,NRXN2,GABBR2,SYT7,DPP10,CNTN5,FGF12,KCNMA1,CACNA1G,GABRB2,GRIA3,KCTD16,CELF4,GRIK2,DLG4,RALYL,RIMS2,CELF2,OLFM1,CACNA1H,KCNC1,MCTP1,NRG3,CADPS,GABRA1,TENM1,HCN1,PDE2A,ALK,KCNT1,GRID2,CSMD2,CACNA1A,GRIN2B,STXBP5,GRM7
3.078e-07	-14.99	GABA receptor activity	molecular function	GO:0016917	22	4	18094	48	GABRB2,GABBR2,GABRA1,GABRD
3.167e-07	-14.97	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	38	16828	48	CELF4,GRIK2,FAM131A,RALYL,GRIA3,KCTD16,CACNA1H,OLFM1,RIMS2,DLG3,DPP10,NRXN2,NRXN1,GABBR2,KCNIP2,GABRB2,CHRM2,GABRD,CACNA1G,KCNMA1,GPR85,CNTN5,NTRK3,KCNT1,STXBP5,GRM7,CSMD2,GRIN2B,SYT1,CACNA1A,NRG3,GABRA1,CADPS,KCNC1,ALK,TENM1,SCN8A,HCN1
3.167e-07	-14.97	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	38	16828	48	KCNT1,NTRK3,CSMD2,GRIN2B,SYT1,CACNA1A,STXBP5,GRM7,KCNC1,NRG3,GABRA1,CADPS,TENM1,SCN8A,HCN1,ALK,KCTD16,GRIA3,GRIK2,CELF4,FAM131A,RALYL,RIMS2,CACNA1H,OLFM1,NRXN2,NRXN1,GABBR2,KCNIP2,DLG3,DPP10,GABRD,GPR85,KCNMA1,CACNA1G,CNTN5,GABRB2,CHRM2
3.331e-07	-14.91	ionotropic glutamate receptor signaling pathway	biological process	GO:0035235	23	4	18204	47	GRIN1,GRIK2,GRIA3,GRIN2B
3.604e-07	-14.84	establishment of localization	biological process	GO:0051234	3887	26	18204	47	GRIK2,KCNMA1,KCNT1,SYT1,NRXN2,HCN1,NRXN1,CACNA1H,GRIN1,SYT7,DLG4,CADPS,GABRB2,GABRA1,RIMS2,STXBP5,KCNIP2,GRID2,KCNC1,GRIA3,GABRD,CACNA1A,ASIC2,SCN8A,CACNA1G,GRIN2B
3.676e-07	-14.82	behavior	biological process	GO:0007610	619	11	18204	47	GRIK2,GRIN1,GRM7,CSMD1,FGF12,DLG4,HCN1,NRXN2,ALK,NRXN1,GRIN2B
3.801e-07	-14.78	monoatomic cation transport	biological process	GO:0006812	766	12	18204	47	KCNC1,KCNIP2,HCN1,KCNT1,KCNMA1,GRIN2B,CACNA1G,SCN8A,ASIC2,CACNA1A,GRIN1,CACNA1H
3.812e-07	-14.78	regulation of neuronal synaptic plasticity	biological process	GO:0048168	58	5	18204	47	GRIN1,GRIK2,DLG4,MCTP1,GRIN2B
3.862e-07	-14.77	transport	biological process	GO:0006810	3615	25	18204	47	NRXN1,SYT1,HCN1,NRXN2,KCNT1,KCNMA1,GRIK2,CADPS,CACNA1H,SYT7,GRIN1,KCNIP2,GRIA3,KCNC1,GRID2,STXBP5,RIMS2,GABRA1,GABRB2,GRIN2B,SCN8A,CACNA1G,CACNA1A,ASIC2,GABRD
4.518e-07	-14.61	transmembrane signaling receptor activity	molecular function	GO:0004888	1251	15	18094	48	GPR85,GABBR2,GRIK2,GRID2,GABRD,GABRA1,GRIA3,ALK,GRIN1,GRIN2B,CHRM2,NTRK3,NRXN2,GRM7,GABRB2
4.775e-07	-14.55	DLG2 (discs large MAGUK scaffold protein 2)	protein interactions	1740	62	5	19454	49	GRIN1,GRIN2B,GRID2,DLG4,DLG3
6.059e-07	-14.32	cell junction assembly	biological process	GO:0034329	285	8	18204	47	NRXN1,GRID2,NRG3,CNTN5,NRXN2,ASIC2,GABRA1,GABRB2
6.359e-07	-14.27	signaling receptor activity	molecular function	GO:0038023	1474	16	18094	48	GABRD,GRID2,GRIA3,ALK,GABRA1,GPR85,GABBR2,GRIK2,NRXN1,GRM7,GABRB2,NRXN2,NTRK3,GRIN1,CHRM2,GRIN2B
6.359e-07	-14.27	molecular transducer activity	molecular function	GO:0060089	1474	16	18094	48	GRIN1,GRIN2B,CHRM2,NRXN1,NTRK3,NRXN2,GABRB2,GRM7,GPR85,GRIK2,GABBR2,GRID2,GABRD,GABRA1,GRIA3,ALK
6.955e-07	-14.18	GRIK2 (glutamate ionotropic receptor kainate type subunit 2)	protein interactions	2898	28	4	19454	49	GRID2,DLG3,GRIK2,DLG4
7.295e-07	-14.13	Volt_channel_dom_sf	interpro domains	IPR027359	63	5	18521	50	KCNC1,CACNA1G,SCN8A,CACNA1H,CACNA1A
7.630e-07	-14.09	synaptic transmission, GABAergic	biological process	GO:0051932	28	4	18204	47	GABRD,GABRB2,GABBR2,GABRA1
7.897e-07	-14.05	excitatory postsynaptic potential	biological process	GO:0060079	67	5	18204	47	GRIK2,GRIN1,CELF4,GRIN2B,GRID2
8.083e-07	-14.03	potassium channel activity	molecular function	GO:0005267	122	6	18094	48	KCNC1,KCNT1,GRIK2,HCN1,KCNMA1,KCNIP2
8.175e-07	-14.02	cell junction organization	biological process	GO:0034330	532	10	18204	47	ASIC2,GPHN,GABRB2,GABRA1,NRG3,GRID2,NRXN1,CNTN5,NRXN2,DLG4
8.793e-07	-13.94	GABAergic synapse	KEGG pathways	ko04727	88	6	7161	28	GABRB2,CACNA1A,GABBR2,GPHN,GABRD,GABRA1
8.793e-07	-13.94	GABAergic synapse	KEGG pathways	hsa04727	88	6	7161	28	GABRA1,GABRB2,CACNA1A,GABBR2,GABRD,GPHN
8.834e-07	-13.94	regulation of presynaptic membrane potential	biological process	GO:0099505	29	4	18204	47	GRIK2,GRIA3,GRIN2B,KCNC1
8.834e-07	-13.94	gamma-aminobutyric acid signaling pathway	biological process	GO:0007214	29	4	18204	47	GABRA1,GABRB2,GABRD,GABBR2
8.834e-07	-13.94	postsynaptic membrane organization	biological process	GO:0001941	29	4	18204	47	DLG4,NRXN2,NRXN1,GPHN
8.870e-07	-13.94	neuron projection terminus	cellular component	GO:0044306	128	6	19108	49	KCNC1,SYT1,CHRM2,GRIN1,DLG4,GRIK2
1.037e-06	-13.78	nervous system process	biological process	GO:0050877	1376	15	18204	47	FGF12,CNTN5,DLG4,GRIN2B,SCN8A,GRIN1,GRM7,ASIC2,CSMD1,CELF4,HCN1,NRXN2,NRXN1,GRID2,GRIK2
1.073e-06	-13.75	Morphine addiction	KEGG pathways	hsa05032	91	6	7161	28	GABRD,GABRA1,CACNA1A,GABBR2,GABRB2,PDE2A
1.073e-06	-13.75	Morphine addiction	KEGG pathways	ko05032	91	6	7161	28	GABRD,GABRA1,CACNA1A,GABBR2,GABRB2,PDE2A
1.128e-06	-13.70	scaffold protein binding	molecular function	GO:0097110	70	5	18094	48	GRID2,GRIK2,CACNA1G,DLG4,CACNA1H
1.214e-06	-13.62	chemical synaptic transmission, postsynaptic	biological process	GO:0099565	73	5	18204	47	GRID2,CELF4,GRIN2B,GRIN1,GRIK2
1.330e-06	-13.53	ligand-gated ion channel signaling pathway	biological process	GO:1990806	32	4	18204	47	GRIN2B,GRIA3,GRIK2,GRIN1
1.330e-06	-13.53	lower_third	COSMIC cancer mutations	lower_third	7961	39	16828	48	KCNT1,GRID2,NTRK3,CACNA1A,GRIN2B,CSMD2,GRM7,STXBP5,KCNC1,CADPS,GABRA1,NRG3,HCN1,SCN8A,TENM1,ALK,PDE2A,KCTD16,GRIA3,FAM131A,RALYL,CELF4,GRIK2,GRIN1,RIMS2,CELF2,CACNA1H,GABBR2,NRXN1,NRXN2,DPP10,SYT7,CNTN5,CACNA1G,KCNMA1,GABRD,CELF5,CHRM2,GABRB2
1.512e-06	-13.40	regulation of transport	biological process	GO:0051049	1621	16	18204	47	RIMS2,STXBP5,KCNIP2,KCNC1,SYT1,ASIC2,GRM7,DPP10,TENM1,GRIN1,SYT7,GRIN2B,CADPS,FGF12,MCTP1,DLG4
1.539e-06	-13.38	neurotransmitter transport	biological process	GO:0006836	140	6	18204	47	RIMS2,SYT7,NRXN1,CADPS,SYT1,NRXN2
1.773e-06	-13.24	Voltage-gated potassium channels. Chain C	gene3d domains	1.20.120.350	63	5	14470	47	CACNA1A,KCNC1,CACNA1G,CACNA1H,SCN8A
1.780e-06	-13.24	GRIN3A (glutamate ionotropic receptor NMDA type subunit 3A)	protein interactions	116443	10	3	19454	49	DLG4,GRIN2B,GRIN1
2.426e-06	-12.93	response to metal ion	biological process	GO:0010038	343	8	18204	47	CACNA1G,KCNC1,KCNIP2,DLG4,SYT1,GPHN,KCNMA1,CACNA1H
2.642e-06	-12.84	dense core granule	cellular component	GO:0031045	38	4	19108	49	SYT7,STXBP5,SYT1,CADPS
3.009e-06	-12.71	Solute-binding_3/MltF_N	interpro domains	IPR001638	11	3	18521	50	GRIN2B,GRIA3,GRIN1
3.053e-06	-12.70	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	14	16828	48	HCN1,ALK,CHRM2,GABBR2,MCTP1,NRG3,SYT7,GRIN2B,CSMD2,GRM7,RALYL,GRID2,NTRK3,CELF4
3.053e-06	-12.70	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	14	16828	48	GRIN2B,CSMD2,GRM7,RALYL,NTRK3,GRID2,CELF4,HCN1,ALK,CHRM2,GABBR2,MCTP1,NRG3,SYT7
3.188e-06	-12.66	SBP_bac_3	pfam domains	PF00497	11	3	17795	49	GRIN2B,GRIN1,GRIA3
3.275e-06	-12.63	DLG4 (discs large MAGUK scaffold protein 4)	protein interactions	1742	163	6	19454	49	DLG3,GRIN1,DLG4,GRIK2,GRIA3,GRIN2B
3.653e-06	-12.52	potassium ion transmembrane transporter activity	molecular function	GO:0015079	158	6	18094	48	KCNIP2,KCNMA1,HCN1,KCNC1,KCNT1,GRIK2
3.705e-06	-12.51	GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)	protein interactions	2891	42	4	19454	49	GRID2,GRIK2,DLG4,GRIA3
4.360e-06	-12.34	Activation of Ca-permeable Kainate Receptor	REACTOME pathways	R-HSA-451308	12	3	10285	29	GRIK2,DLG3,DLG4
4.360e-06	-12.34	Ionotropic activity of Kainate Receptors	REACTOME pathways	R-HSA-451306	12	3	10285	29	DLG3,GRIK2,DLG4
4.375e-06	-12.34	hippocampal mossy fiber to CA3 synapse	cellular component	GO:0098686	43	4	19108	49	SYT1,GRIK2,SYT7,STXBP5
4.489e-06	-12.31	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	5	18204	47	CACNA1H,GRIN1,CACNA1A,GRIN2B,CACNA1G
4.702e-06	-12.27	developmental process	biological process	GO:0032502	5716	30	18204	47	GABRA1,GABRB2,PDE2A,RIMS2,DLG3,KCNC1,GRID2,NTRK3,KCNIP2,TENM1,CSMD1,ASIC2,CNTN5,GRIN2B,SCN8A,CACNA1G,OLFM1,HCN1,NRXN2,SYT1,NRXN1,NRG3,GRIN1,CACNA1H,CELF4,GRM7,DLG4,FGF12,CHRM2,ALK
4.803e-06	-12.25	Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME pathways	R-HSA-442755	41	4	10285	29	GRIN1,DLG4,GRIA3,GRIN2B
4.823e-06	-12.24	cellular component assembly	biological process	GO:0022607	2472	19	18204	47	GRIN2B,CNTN5,DLG4,ASIC2,CELF4,CELF2,SYT7,GRIN1,CELF5,NRXN1,KCNC1,GRID2,NRG3,SYT1,HCN1,NRXN2,KCTD16,GABRA1,GABRB2
4.908e-06	-12.22	synaptic transmission, glutamatergic	biological process	GO:0035249	44	4	18204	47	GRIK2,GRID2,GRIN2B,GRIA3
4.985e-06	-12.21	sodium channel activity	molecular function	GO:0005272	43	4	18094	48	HCN1,SCN8A,ASIC2,GRIK2
5.030e-06	-12.20	regulation of cell communication	biological process	GO:0010646	3541	23	18204	47	CHRM2,ALK,DLG4,FGF12,CELF4,GRM7,SYT7,GRIN1,NRXN1,NRG3,SYT1,KCTD16,GRIK2,GRIN2B,MCTP1,TENM1,CACNA1A,GRIA3,GRID2,NTRK3,PDE2A,STXBP5,RIMS2
5.195e-06	-12.17	VGCC_Ca_Na	interpro domains	IPR043203	13	3	18521	50	CACNA1G,CACNA1H,SCN8A
5.245e-06	-12.16	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	45	16828	48	DLG4,RALYL,KCTD16,CELF2,CACNA1H,DPP10,SYT7,KCNIP2,CHRM2,CNTN5,FGF12,CELF5,NTRK3,GRID2,KCNT1,STXBP5,GRIN2B,SYT1,GPHN,NRG3,KCNC1,HCN1,FAM131A,CELF4,GRIK2,GRIN1,GRIA3,OLFM1,RIMS2,GABBR2,NRXN1,NRXN2,KCNMA1,CACNA1G,GABRD,GRM7,CACNA1A,CSMD2,CADPS,GABRA1,MCTP1,ALK,PDE2A,SCN8A,TENM1
5.917e-06	-12.04	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	36	16828	48	DLG3,SYT7,DPP10,NRXN1,NRXN2,KCNIP2,GABBR2,GABRB2,GABRD,CELF5,CNTN5,FGF12,CACNA1G,GRIN1,CELF4,RALYL,KCTD16,GRIA3,CELF2,CACNA1H,RIMS2,GABRA1,NRG3,MCTP1,PDE2A,ALK,TENM1,HCN1,GRID2,NTRK3,KCNT1,STXBP5,GRM7,CSMD2,GRIN2B,SYT1
6.248e-06	-11.98	high voltage-gated calcium channel activity	molecular function	GO:0008331	14	3	18094	48	CACNA1H,CACNA1G,CACNA1A
6.293e-06	-11.98	voltage-gated potassium channel activity	molecular function	GO:0005249	99	5	18094	48	KCNMA1,KCNIP2,KCNC1,KCNT1,HCN1
6.891e-06	-11.89	low voltage-gated calcium channel activity	molecular function	GO:0008332	2	2	18094	48	CACNA1H,CACNA1G
6.982e-06	-11.87	calcium-ion regulated exocytosis	biological process	GO:0017156	48	4	18204	47	RIMS2,CADPS,SYT1,SYT7
7.147e-06	-11.85	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	14	16828	48	GRIK2,OLFM1,GRM7,CSMD2,CACNA1A,RIMS2,GRIN2B,NRG3,KCNIP2,ALK,CHRM2,CNTN5,HCN1,SCN8A
7.147e-06	-11.85	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	14	16828	48	CACNA1A,GRIN2B,RIMS2,CSMD2,GRM7,OLFM1,GRIK2,HCN1,CNTN5,SCN8A,ALK,CHRM2,KCNIP2,NRG3
7.941e-06	-11.74	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	48	16828	48	GRM7,CACNA1A,CSMD2,ALK,PDE2A,SCN8A,TENM1,GABRA1,CADPS,MCTP1,OLFM1,RIMS2,FAM131A,GRIK2,CELF4,GRIN1,GRIA3,KCNMA1,GPR85,CACNA1G,GABRD,GABBR2,NRXN2,NRXN1,STXBP5,SYT1,GRIN2B,NTRK3,GRID2,KCNT1,HCN1,GPHN,NRG3,KCNC1,CACNA1H,CELF2,DLG4,RALYL,KCTD16,CHRM2,GABRB2,FGF12,CNTN5,CELF5,DPP10,SYT7,DLG3,KCNIP2
8.459e-06	-11.68	signal release	biological process	GO:0023061	188	6	18204	47	SYT1,SYT7,NRXN2,RIMS2,NRXN1,CADPS
9.099e-06	-11.61	anatomical structure development	biological process	GO:0048856	5207	28	18204	47	OLFM1,NRXN2,HCN1,NRG3,NRXN1,CACNA1H,GRIN1,GRM7,CELF4,FGF12,DLG4,ALK,CHRM2,GABRB2,GABRA1,DLG3,PDE2A,KCNIP2,NTRK3,GRID2,KCNC1,CSMD1,ASIC2,TENM1,CNTN5,SCN8A,CACNA1G,GRIN2B
9.207e-06	-11.60	SNARE binding	molecular function	GO:0000149	107	5	18094	48	STXBP5,CACNA1A,SYT1,SYT7,GRIK2
9.577e-06	-11.56	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0099507	16	3	18094	48	GRIK2,GRIN2B,GRIA3
9.961e-06	-11.52	GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C)	protein interactions	2905	17	3	19454	49	DLG3,DLG4,GRIN1
1.052e-05	-11.46	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	33	16828	48	HCN1,ALK,KCNC1,GABRA1,CADPS,NRG3,CSMD2,GRIN2B,CACNA1A,GRM7,KCNT1,GRID2,NTRK3,CELF5,GABRD,CACNA1G,KCNMA1,CNTN5,GABRB2,CHRM2,NRXN2,NRXN1,GABBR2,DPP10,RIMS2,CACNA1H,CELF2,KCTD16,GRIA3,GRIK2,CELF4,FAM131A,RALYL
1.081e-05	-11.43	response to stimulus	biological process	GO:0050896	7803	35	18204	47	ALK,CHRM2,FGF12,GABBR2,DLG4,GRM7,CELF4,CACNA1H,SYT7,GRIN1,NRXN1,NRG3,SYT1,HCN1,NRXN2,KCNMA1,GPR85,OLFM1,GPHN,GRIK2,GRIN2B,CACNA1G,MCTP1,CSMD1,ASIC2,CACNA1A,TENM1,NTRK3,KCNIP2,KCNC1,GRIA3,GRID2,RIMS2,PDE2A,GABRB2
1.105e-05	-11.41	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	26	16828	48	CACNA1H,RIMS2,CELF4,RALYL,KCTD16,GRIA3,CELF5,FGF12,KCNMA1,SYT7,DPP10,NRXN2,KCNIP2,GABBR2,GRM7,CSMD2,SYT1,GRIN2B,GRID2,ALK,HCN1,SCN8A,NRG3,CADPS,GABRA1,MCTP1
1.281e-05	-11.27	calcium ion-regulated exocytosis of neurotransmitter	biological process	GO:0048791	18	3	18204	47	SYT7,SYT1,RIMS2
1.298e-05	-11.25	cardiac muscle cell action potential	biological process	GO:0086001	56	4	18204	47	FGF12,SCN8A,CACNA1G,KCNIP2
1.335e-05	-11.22	CREB phosphorylation through the activation of CaMKII	REACTOME pathways	R-HSA-442729	17	3	10285	29	DLG4,GRIN2B,GRIN1
1.363e-05	-11.20	GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B)	protein interactions	2904	58	4	19454	49	DLG3,DLG4,GRIN2B,GRIN1
1.404e-05	-11.17	mouth	COSMIC cancer mutations	mouth	9004	40	16828	48	GRIA3,KCTD16,RALYL,DLG4,FAM131A,GRIK2,GRIN1,RIMS2,CELF2,CACNA1H,KCNIP2,GABBR2,NRXN1,NRXN2,DLG3,SYT7,CNTN5,CACNA1G,KCNMA1,GABRD,CELF5,CHRM2,GABRB2,KCNT1,GRID2,NTRK3,CACNA1A,GRIN2B,SYT1,CSMD2,GRM7,MCTP1,KCNC1,CADPS,GABRA1,NRG3,HCN1,SCN8A,ALK,PDE2A
1.423e-05	-11.16	calcium channel activity	molecular function	GO:0005262	117	5	18094	48	CACNA1A,GRIN1,CACNA1H,GRIN2B,CACNA1G
1.460e-05	-11.13	SYNGAP1 (synaptic Ras GTPase activating protein 1)	protein interactions	8831	59	4	19454	49	GRIN1,GRIN2B,DLG4,DLG3
1.492e-05	-11.11	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	3	19108	49	GRID2,SCN8A,GRIA3
1.492e-05	-11.11	GABA-A receptor complex	cellular component	GO:1902711	19	3	19108	49	GABRA1,GABRD,GABRB2
1.518e-05	-11.10	excitatory synapse assembly	biological process	GO:1904861	19	3	18204	47	NRXN2,NRXN1,GRID2
1.518e-05	-11.10	vocalization behavior	biological process	GO:0071625	19	3	18204	47	NRXN1,DLG4,NRXN2
1.518e-05	-11.10	response to potassium ion	biological process	GO:0035864	19	3	18204	47	KCNC1,CACNA1H,DLG4
1.557e-05	-11.07	DLG1 (discs large MAGUK scaffold protein 1)	protein interactions	1739	214	6	19454	49	NTRK3,GRIN1,GRIN2B,KCNC1,DLG3,GRIK2
1.599e-05	-11.04	protein localization to synapse	biological process	GO:0035418	59	4	18204	47	DLG4,NRXN2,ASIC2,NRXN1
1.648e-05	-11.01	GABA-A receptor activity	molecular function	GO:0004890	19	3	18094	48	GABRD,GABRA1,GABRB2
1.696e-05	-10.98	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	33	16828	48	KCNT1,GRID2,NTRK3,CACNA1A,SYT1,GRIN2B,CSMD2,GRM7,MCTP1,KCNC1,NRG3,CADPS,GABRA1,HCN1,SCN8A,ALK,PDE2A,KCTD16,FAM131A,RALYL,DLG4,GRIN1,GRIK2,CACNA1H,GABBR2,NRXN2,DLG3,SYT7,CNTN5,CACNA1G,KCNMA1,GABRD,CELF5
1.861e-05	-10.89	Baiap2 (brain-specific angiogenesis inhibitor 1-associated protein 2)	protein interactions	108100	3	2	19454	49	DLG4,DLG3
1.895e-05	-10.87	Ras activation uopn Ca2+ infux through NMDA receptor	REACTOME pathways	R-HSA-442982	19	3	10285	29	GRIN2B,DLG4,GRIN1
1.897e-05	-10.87	NLGN2 (neuroligin 2)	protein interactions	57555	63	4	19454	49	DLG4,NRXN1,NRXN2,DLG3
1.906e-05	-10.87	syntaxin binding	molecular function	GO:0019905	60	4	18094	48	SYT7,SYT1,STXBP5,CACNA1A
1.913e-05	-10.86	regulation of signaling	biological process	GO:0023051	3534	22	18204	47	MCTP1,DLG4,ALK,CHRM2,GRIN2B,GRIN1,SYT7,CACNA1A,GRM7,TENM1,CELF4,SYT1,NTRK3,GRID2,NRG3,GRIA3,NRXN1,GRIK2,RIMS2,STXBP5,PDE2A,KCTD16
1.933e-05	-10.85	cellular component biogenesis	biological process	GO:0044085	2716	19	18204	47	CELF5,KCNC1,NRXN1,GRID2,NRG3,SYT1,HCN1,NRXN2,KCTD16,GABRA1,GABRB2,GRIN2B,CNTN5,DLG4,ASIC2,CELF4,CELF2,SYT7,GRIN1
1.934e-05	-10.85	KCND2 (potassium voltage-gated channel subfamily D member 2)	protein interactions	3751	21	3	19454	49	DPP10,DLG4,KCNIP2
1.954e-05	-10.84	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	2	18204	47	NRXN1,NRXN2
2.078e-05	-10.78	synaptic vesicle exocytosis	biological process	GO:0016079	63	4	18204	47	CADPS,RIMS2,SYT7,SYT1
2.118e-05	-10.76	synaptic vesicle	cellular component	GO:0008021	222	6	19108	49	SYT1,GRIN1,DLG4,MCTP1,STXBP5,SYT7
2.139e-05	-10.75	VDCC_T_a1	interpro domains	IPR005445	3	2	18521	50	CACNA1H,CACNA1G
2.501e-05	-10.60	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	17	16828	48	KCNIP2,GABBR2,KCNC1,NRXN2,DPP10,NRG3,FGF12,HCN1,GPR85,ALK,CHRM2,KCTD16,GRIN2B,CSMD2,GRM7,CELF2,STXBP5
2.528e-05	-10.59	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	20	16828	48	ALK,PDE2A,SCN8A,CELF5,GABRA1,CADPS,NRG3,GABBR2,MCTP1,GRM7,OLFM1,RIMS2,GRIN2B,SYT1,CSMD2,RALYL,GRID2,CELF4,GRIA3,KCNT1
2.656e-05	-10.54	multicellular organismal process	biological process	GO:0032501	6177	30	18204	47	TENM1,ASIC2,CSMD1,SCN8A,CACNA1G,GRIN2B,CNTN5,PDE2A,DLG3,GABRB2,GABRA1,GRID2,KCNC1,KCNIP2,NTRK3,CELF4,GRM7,GRIN1,CACNA1H,CHRM2,ALK,DLG4,FGF12,OLFM1,KCNMA1,GRIK2,NRG3,NRXN1,NRXN2,HCN1
2.673e-05	-10.53	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	15	16828	48	FAM131A,GRIK2,NTRK3,GRID2,KCTD16,KCNT1,CACNA1H,CACNA1A,RIMS2,DPP10,DLG3,ALK,PDE2A,CNTN5,CACNA1G
2.673e-05	-10.53	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	15	16828	48	CACNA1A,RIMS2,CACNA1H,KCNT1,KCTD16,GRIK2,NTRK3,GRID2,FAM131A,CNTN5,CACNA1G,PDE2A,ALK,DLG3,DPP10
2.715e-05	-10.51	regulation of localization	biological process	GO:0032879	2028	16	18204	47	TENM1,GRM7,DPP10,ASIC2,SYT7,GRIN1,CADPS,GRIN2B,DLG4,FGF12,MCTP1,STXBP5,RIMS2,KCNC1,KCNIP2,SYT1
2.750e-05	-10.50	GABAA/Glycine_rcpt	interpro domains	IPR006028	22	3	18521	50	GABRD,GABRB2,GABRA1
2.810e-05	-10.48	regulation of monoatomic ion transmembrane transport	biological process	GO:0034765	347	7	18204	47	KCNIP2,ASIC2,DPP10,KCNC1,GRIN2B,FGF12,GRIN1
2.943e-05	-10.43	transmembrane transporter binding	molecular function	GO:0044325	136	5	18094	48	KCNIP2,DPP10,RIMS2,FGF12,KCNC1
2.943e-05	-10.43	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	5	18094	48	CACNA1H,GRIN2B,CACNA1G,CACNA1A,GRIN1
2.989e-05	-10.42	voltage-gated sodium channel activity	molecular function	GO:0005248	23	3	18094	48	HCN1,SCN8A,ASIC2
3.002e-05	-10.41	Circadian entrainment	KEGG pathways	ko04713	96	5	7161	28	GRIN1,CACNA1G,CACNA1H,GRIN2B,GRIA3
3.002e-05	-10.41	Circadian entrainment	KEGG pathways	hsa04713	96	5	7161	28	GRIA3,GRIN2B,CACNA1H,GRIN1,CACNA1G
3.022e-05	-10.41	export from cell	biological process	GO:0140352	485	8	18204	47	KCNIP2,CADPS,NRXN1,SYT1,NRXN2,STXBP5,RIMS2,SYT7
3.022e-05	-10.41	regulation of transmembrane transport	biological process	GO:0034762	485	8	18204	47	ASIC2,DPP10,GRIN1,KCNIP2,GRIN2B,KCNC1,FGF12,DLG4
3.115e-05	-10.38	neuronal cell body	cellular component	GO:0043025	489	8	19108	49	CACNA1A,NRXN1,CHRM2,KCNC1,GABRD,OLFM1,GRIK2,ASIC2
3.215e-05	-10.34	muscle contraction	biological process	GO:0006936	238	6	18204	47	FGF12,CACNA1G,SCN8A,KCNIP2,CACNA1H,KCNMA1
3.222e-05	-10.34	GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A)	protein interactions	2903	72	4	19454	49	GRIN1,GRIN2B,DLG4,DLG3
3.360e-05	-10.30	exocytic vesicle	cellular component	GO:0070382	241	6	19108	49	SYT1,DLG4,STXBP5,GRIN1,MCTP1,SYT7
3.383e-05	-10.29	ion channel regulator activity	molecular function	GO:0099106	140	5	18094	48	KCNIP2,DPP10,FGF12,NRXN1,NRXN2
3.717e-05	-10.20	Grin2a (glutamate receptor, ionotropic, NMDA2A (epsilon 1))	protein interactions	14811	4	2	19454	49	GRIN1,GRIN2B
3.742e-05	-10.19	biological regulation	biological process	GO:0065007	12501	44	18204	47	SYT7,FGF12,CADPS,KCNMA1,GPR85,OLFM1,HCN1,NRXN2,NRG3,CACNA1A,TENM1,GRIN2B,CACNA1G,STXBP5,DLG3,PDE2A,NTRK3,KCNIP2,GRIA3,KCNC1,CACNA1H,GRIN1,GRM7,DPP10,CELF4,GABBR2,DLG4,ALK,CHRM2,GRIK2,GPHN,KCTD16,SYT1,CELF5,NRXN1,GABRD,ASIC2,CELF2,MCTP1,SCN8A,GABRA1,GABRB2,RIMS2,GRID2
3.838e-05	-10.17	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	5	7161	28	GABRB2,CACNA1A,GABRD,GABRA1,GRIA3
3.838e-05	-10.17	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	5	7161	28	GRIA3,GABRA1,GABRD,CACNA1A,GABRB2
3.953e-05	-10.14	AMPA glutamate receptor complex	cellular component	GO:0032281	26	3	19108	49	DLG3,GRIA3,DLG4
3.994e-05	-10.13	neuromuscular process	biological process	GO:0050905	149	5	18204	47	NRXN1,GRID2,CSMD1,DLG4,FGF12
4.002e-05	-10.13	channel regulator activity	molecular function	GO:0016247	145	5	18094	48	KCNIP2,DPP10,FGF12,NRXN1,NRXN2
4.027e-05	-10.12	response to inorganic substance	biological process	GO:0010035	505	8	18204	47	KCNMA1,GPHN,CACNA1H,KCNIP2,KCNC1,CACNA1G,SYT1,DLG4
4.098e-05	-10.10	C2_dom	interpro domains	IPR000008	143	5	18521	50	CADPS,SYT1,MCTP1,SYT7,RIMS2
4.135e-05	-10.09	transporter regulator activity	molecular function	GO:0141108	146	5	18094	48	DPP10,FGF12,NRXN1,KCNIP2,NRXN2
4.144e-05	-10.09	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	biological process	GO:0007193	75	4	18204	47	GABBR2,PDE2A,CHRM2,GRM7
4.145e-05	-10.09	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	23	16828	48	CACNA1H,GRIA3,KCTD16,CELF4,RALYL,CELF5,FGF12,NRXN2,KCNIP2,GABBR2,SYT7,CSMD2,GRIN2B,SYT1,GRM7,GRID2,HCN1,SCN8A,ALK,MCTP1,GABRA1,CADPS,NRG3
4.271e-05	-10.06	K_chnl_Slo-like	interpro domains	IPR047871	4	2	18521	50	KCNT1,KCNMA1
4.271e-05	-10.06	DLG1-like	interpro domains	IPR016313	4	2	18521	50	DLG3,DLG4
4.271e-05	-10.06	DLG1_PEST_dom	interpro domains	IPR019590	4	2	18521	50	DLG4,DLG3
4.271e-05	-10.06	DLG1-4_PDZ_assoc	interpro domains	IPR019583	4	2	18521	50	DLG4,DLG3
4.271e-05	-10.06	CELF3/4/5/6_RRM1	interpro domains	IPR034648	4	2	18521	50	CELF5,CELF4
4.271e-05	-10.06	K_chnl_BK_asu	interpro domains	IPR003929	4	2	18521	50	KCNT1,KCNMA1
4.366e-05	-10.04	positive regulation of exocytosis	biological process	GO:0045921	76	4	18204	47	SYT1,SYT7,STXBP5,CADPS
4.441e-05	-10.02	PDZ_assoc	pfam domains	PF10600	4	2	17795	49	DLG3,DLG4
4.441e-05	-10.02	BK_channel_a	pfam domains	PF03493	4	2	17795	49	KCNT1,KCNMA1
4.594e-05	-9.99	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	20	16828	48	GRM7,OLFM1,SYT1,GRIN2B,RIMS2,CSMD2,RALYL,GRID2,CELF4,GRIA3,KCNT1,ALK,PDE2A,SCN8A,CELF5,CADPS,GABRA1,NRG3,GABBR2,MCTP1
4.676e-05	-9.97	learning	biological process	GO:0007612	154	5	18204	47	CSMD1,NRXN1,DLG4,GRIN1,NRXN2
4.735e-05	-9.96	GABA-ergic synapse	cellular component	GO:0098982	78	4	19108	49	GABRB2,CNTN5,GABRD,GABRA1
4.755e-05	-9.95	face	COSMIC cancer mutations	face	2139	17	16828	48	GPR85,HCN1,FGF12,CHRM2,ALK,KCNC1,NRXN2,GABBR2,KCNIP2,NRG3,DPP10,CSMD2,GRIN2B,STXBP5,CELF2,GRM7,KCTD16
4.831e-05	-9.94	protein complex oligomerization	biological process	GO:0051259	256	6	18204	47	SYT1,HCN1,GRIN1,KCNC1,GRIN2B,KCTD16
4.844e-05	-9.94	lymph_node	COSMIC cancer mutations	lymph_node	1703	15	16828	48	CACNA1H,CSMD2,GRIN2B,RIMS2,GRIK2,CELF4,NTRK3,GRID2,RALYL,ALK,CADPS,NRG3,DLG3,DPP10,GABBR2
4.978e-05	-9.91	presynaptic active zone	cellular component	GO:0048786	79	4	19108	49	GRM7,RIMS2,SCN8A,HCN1
5.050e-05	-9.89	calcium ion import across plasma membrane	biological process	GO:0098703	28	3	18204	47	CACNA1G,CACNA1A,CACNA1H
5.124e-05	-9.88	GRIP1 (glutamate receptor interacting protein 1)	protein interactions	23426	81	4	19454	49	FGF12,GRIK2,GRIA3,GRM7
5.240e-05	-9.86	CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2)	protein interactions	10369	29	3	19454	49	DLG3,DLG4,GRIN1
5.379e-05	-9.83	regulation of blood circulation	biological process	GO:1903522	261	6	18204	47	CACNA1H,ASIC2,CELF2,KCNIP2,CACNA1G,CHRM2
5.623e-05	-9.79	protein heterooligomerization	biological process	GO:0051291	29	3	18204	47	GRIN2B,GRIN1,SYT1
5.623e-05	-9.79	calcium ion import into cytosol	biological process	GO:1902656	29	3	18204	47	CACNA1G,CACNA1A,CACNA1H
5.643e-05	-9.78	C2	prosite domains	PS50004	142	5	12186	36	SYT7,SYT1,RIMS2,CADPS,MCTP1
5.886e-05	-9.74	regulation of neurotransmitter secretion	biological process	GO:0046928	82	4	18204	47	RIMS2,STXBP5,SYT1,MCTP1
6.236e-05	-9.68	neuronal action potential	biological process	GO:0019228	30	3	18204	47	SCN8A,GRIK2,HCN1
6.410e-05	-9.65	neuronal dense core vesicle membrane	cellular component	GO:0099012	5	2	19108	49	STXBP5,CADPS
6.492e-05	-9.64	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	2	18204	47	NRXN2,NRXN1
6.492e-05	-9.64	potassium ion transmembrane transport	biological process	GO:0071805	165	5	18204	47	HCN1,KCNC1,KCNT1,KCNIP2,KCNMA1
6.512e-05	-9.64	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	17	16828	48	GRIA3,KCNT1,RALYL,GRID2,CELF4,RIMS2,GRIN2B,CSMD2,GRM7,CACNA1H,GABBR2,NRXN2,NRG3,CACNA1G,HCN1,FGF12,ALK
6.512e-05	-9.64	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	17	16828	48	RALYL,GRID2,CELF4,GRIA3,KCNT1,GRM7,CACNA1H,RIMS2,GRIN2B,CSMD2,NRG3,GABBR2,NRXN2,ALK,CACNA1G,FGF12,HCN1
6.764e-05	-9.60	monoatomic ion-gated channel activity	molecular function	GO:0022839	30	3	18094	48	KCNMA1,ASIC2,KCNT1
7.011e-05	-9.57	CREB phosphorylation through the activation of Ras	REACTOME pathways	R-HSA-442742	29	3	10285	29	GRIN1,GRIN2B,DLG4
7.089e-05	-9.55	NLGN3 (neuroligin 3)	protein interactions	54413	88	4	19454	49	NRXN1,DLG3,NRXN2,DLG4
7.092e-05	-9.55	protein localization to cell junction	biological process	GO:1902414	86	4	18204	47	NRXN2,DLG4,NRXN1,ASIC2
7.249e-05	-9.53	localization within membrane	biological process	GO:0051668	549	8	18204	47	STXBP5,DPP10,DLG3,GPHN,GRIK2,NRXN1,DLG4,NRXN2
7.271e-05	-9.53	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	17	16828	48	NRG3,GABBR2,NRXN2,ALK,HCN1,FGF12,CACNA1G,RALYL,CELF4,GRID2,GRIA3,KCNT1,GRM7,CACNA1H,RIMS2,GRIN2B,CSMD2
7.330e-05	-9.52	learning or memory	biological process	GO:0007611	276	6	18204	47	GRIN1,NRXN2,DLG4,NRXN1,GRIN2B,CSMD1
7.690e-05	-9.47	regulation of exocytosis	biological process	GO:0017157	171	5	18204	47	SYT1,SYT7,STXBP5,RIMS2,CADPS
7.700e-05	-9.47	cell body	cellular component	GO:0044297	556	8	19108	49	ASIC2,CHRM2,KCNC1,NRXN1,CACNA1A,GRIK2,OLFM1,GABRD
7.717e-05	-9.47	dendritic spine	cellular component	GO:0043197	172	5	19108	49	DLG4,ASIC2,GRIN1,GRID2,GRIA3
7.970e-05	-9.44	MAGUK_N_PEST	smart domains	SM01277	4	2	9717	36	DLG4,DLG3
8.150e-05	-9.41	neuron spine	cellular component	GO:0044309	174	5	19108	49	GRIA3,GRID2,GRIN1,DLG4,ASIC2
8.335e-05	-9.39	response to auditory stimulus	biological process	GO:0010996	33	3	18204	47	KCNC1,NRXN1,NRXN2
8.412e-05	-9.38	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	42	16828	48	CNTN5,FGF12,CACNA1G,KCNMA1,GABRD,CELF5,CHRM2,GABBR2,NRXN1,NRXN2,DPP10,SYT7,RIMS2,CELF2,CACNA1H,GRIA3,FAM131A,DLG4,RALYL,GRIK2,CELF4,GRIN1,HCN1,SCN8A,TENM1,ALK,PDE2A,MCTP1,KCNC1,GPHN,NRG3,CADPS,GABRA1,CACNA1A,SYT1,GRIN2B,CSMD2,GRM7,STXBP5,KCNT1,GRID2,NTRK3
8.412e-05	-9.38	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	42	16828	48	CACNA1G,KCNMA1,FGF12,CNTN5,CELF5,GABRD,CHRM2,GABBR2,NRXN2,NRXN1,DPP10,SYT7,RIMS2,CACNA1H,CELF2,GRIA3,FAM131A,DLG4,RALYL,CELF4,GRIK2,GRIN1,SCN8A,HCN1,TENM1,ALK,PDE2A,MCTP1,KCNC1,GPHN,CADPS,GABRA1,NRG3,GRIN2B,SYT1,CACNA1A,CSMD2,GRM7,STXBP5,KCNT1,NTRK3,GRID2
8.632e-05	-9.36	Felodipine Action Pathway	SMPDB pathways	SMP0000377	57	4	1369	7	CACNA1H,CACNA1G,CHRM2,KCNIP2
8.632e-05	-9.36	Nitrendipine Action Pathway	SMPDB pathways	SMP0000382	57	4	1369	7	KCNIP2,CACNA1H,CACNA1G,CHRM2
8.632e-05	-9.36	Nifedipine Action Pathway	SMPDB pathways	SMP0000379	57	4	1369	7	KCNIP2,CHRM2,CACNA1H,CACNA1G
8.632e-05	-9.36	Fosphenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000326	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Verapamil Action Pathway	SMPDB pathways	SMP0000375	57	4	1369	7	CACNA1H,CACNA1G,CHRM2,KCNIP2
8.632e-05	-9.36	Quinidine Action Pathway	SMPDB pathways	SMP0000323	57	4	1369	7	CACNA1H,CACNA1G,CHRM2,KCNIP2
8.632e-05	-9.36	Nimodipine Action Pathway	SMPDB pathways	SMP0000380	57	4	1369	7	CACNA1H,CACNA1G,CHRM2,KCNIP2
8.632e-05	-9.36	Nebivolol Action Pathway	SMPDB pathways	SMP0000366	57	4	1369	7	KCNIP2,CACNA1G,CHRM2,CACNA1H
8.632e-05	-9.36	Dobutamine Action Pathway	SMPDB pathways	SMP0000662	57	4	1369	7	CACNA1H,CHRM2,CACNA1G,KCNIP2
8.632e-05	-9.36	Metoprolol Action Pathway	SMPDB pathways	SMP0000302	57	4	1369	7	KCNIP2,CHRM2,CACNA1H,CACNA1G
8.632e-05	-9.36	Pindolol Action Pathway	SMPDB pathways	SMP0000306	57	4	1369	7	KCNIP2,CHRM2,CACNA1H,CACNA1G
8.632e-05	-9.36	Acebutolol Action Pathway	SMPDB pathways	SMP0000296	57	4	1369	7	KCNIP2,CACNA1H,CACNA1G,CHRM2
8.632e-05	-9.36	Isradipine Action Pathway	SMPDB pathways	SMP0000378	57	4	1369	7	KCNIP2,CACNA1H,CHRM2,CACNA1G
8.632e-05	-9.36	Flecainide Action Pathway	SMPDB pathways	SMP0000331	57	4	1369	7	KCNIP2,CACNA1H,CHRM2,CACNA1G
8.632e-05	-9.36	Levobunolol Action Pathway	SMPDB pathways	SMP0000666	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Nadolol Action Pathway	SMPDB pathways	SMP0000303	57	4	1369	7	CHRM2,CACNA1G,CACNA1H,KCNIP2
8.632e-05	-9.36	Isoprenaline Action Pathway	SMPDB pathways	SMP0000663	57	4	1369	7	CACNA1H,CACNA1G,CHRM2,KCNIP2
8.632e-05	-9.36	Bisoprolol Action Pathway	SMPDB pathways	SMP0000300	57	4	1369	7	CACNA1G,CACNA1H,CHRM2,KCNIP2
8.632e-05	-9.36	Sotalol Action Pathway	SMPDB pathways	SMP0000660	57	4	1369	7	KCNIP2,CACNA1G,CACNA1H,CHRM2
8.632e-05	-9.36	Nisoldipine Action Pathway	SMPDB pathways	SMP0000381	57	4	1369	7	CACNA1G,CACNA1H,CHRM2,KCNIP2
8.632e-05	-9.36	Timolol Action Pathway	SMPDB pathways	SMP0000659	57	4	1369	7	KCNIP2,CHRM2,CACNA1H,CACNA1G
8.632e-05	-9.36	Bopindolol Action Pathway	SMPDB pathways	SMP0000657	57	4	1369	7	KCNIP2,CACNA1G,CACNA1H,CHRM2
8.632e-05	-9.36	Disopyramide Action Pathway	SMPDB pathways	SMP0000325	57	4	1369	7	CACNA1G,CACNA1H,CHRM2,KCNIP2
8.632e-05	-9.36	Amlodipine Action Pathway	SMPDB pathways	SMP0000376	57	4	1369	7	KCNIP2,CACNA1H,CACNA1G,CHRM2
8.632e-05	-9.36	Mexiletine Action Pathway	SMPDB pathways	SMP0000329	57	4	1369	7	KCNIP2,CACNA1G,CACNA1H,CHRM2
8.632e-05	-9.36	Atenolol Action Pathway	SMPDB pathways	SMP0000298	57	4	1369	7	CACNA1H,CACNA1G,CHRM2,KCNIP2
8.632e-05	-9.36	Bevantolol Action Pathway	SMPDB pathways	SMP0000668	57	4	1369	7	CACNA1H,CHRM2,CACNA1G,KCNIP2
8.632e-05	-9.36	Procainamide (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000324	57	4	1369	7	KCNIP2,CACNA1G,CHRM2,CACNA1H
8.632e-05	-9.36	Carteolol Action Pathway	SMPDB pathways	SMP0000658	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Ibutilide Action Pathway	SMPDB pathways	SMP0000332	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Penbutolol Action Pathway	SMPDB pathways	SMP0000305	57	4	1369	7	KCNIP2,CACNA1G,CHRM2,CACNA1H
8.632e-05	-9.36	Epinephrine Action Pathway	SMPDB pathways	SMP0000661	57	4	1369	7	CACNA1H,CHRM2,CACNA1G,KCNIP2
8.632e-05	-9.36	Amiodarone Action Pathway	SMPDB pathways	SMP0000665	57	4	1369	7	CACNA1H,CHRM2,CACNA1G,KCNIP2
8.632e-05	-9.36	Esmolol Action Pathway	SMPDB pathways	SMP0000301	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Practolol Action Pathway	SMPDB pathways	SMP0000669	57	4	1369	7	KCNIP2,CHRM2,CACNA1H,CACNA1G
8.632e-05	-9.36	Oxprenolol Action Pathway	SMPDB pathways	SMP0000304	57	4	1369	7	CHRM2,CACNA1H,CACNA1G,KCNIP2
8.632e-05	-9.36	Bupranolol Action Pathway	SMPDB pathways	SMP0000670	57	4	1369	7	KCNIP2,CHRM2,CACNA1H,CACNA1G
8.632e-05	-9.36	Betaxolol Action Pathway	SMPDB pathways	SMP0000299	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Arbutamine Action Pathway	SMPDB pathways	SMP0000664	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Diltiazem Action Pathway	SMPDB pathways	SMP0000359	57	4	1369	7	KCNIP2,CACNA1H,CHRM2,CACNA1G
8.632e-05	-9.36	Tocainide Action Pathway	SMPDB pathways	SMP0000330	57	4	1369	7	KCNIP2,CACNA1H,CACNA1G,CHRM2
8.632e-05	-9.36	Alprenolol Action Pathway	SMPDB pathways	SMP0000297	57	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
8.632e-05	-9.36	Propranolol Action Pathway	SMPDB pathways	SMP0000307	57	4	1369	7	KCNIP2,CACNA1G,CHRM2,CACNA1H
8.632e-05	-9.36	Muscle/Heart Contraction	SMPDB pathways	SMP0000588	57	4	1369	7	KCNIP2,CACNA1H,CHRM2,CACNA1G
8.632e-05	-9.36	Metipranolol Action Pathway	SMPDB pathways	SMP0000667	57	4	1369	7	KCNIP2,CHRM2,CACNA1H,CACNA1G
8.811e-05	-9.34	potassium ion transport	biological process	GO:0006813	176	5	18204	47	HCN1,KCNC1,KCNIP2,KCNMA1,KCNT1
8.945e-05	-9.32	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	22	16828	48	CSMD2,GRIN2B,STXBP5,GRM7,GRID2,TENM1,SCN8A,HCN1,PDE2A,ALK,KCNC1,GABRA1,RIMS2,CACNA1H,GRIK2,CELF4,GRIN1,CELF5,CACNA1G,NRXN2,SYT7,DPP10
9.020e-05	-9.31	amyloid-beta binding	molecular function	GO:0001540	89	4	18094	48	GRIN2B,GRIA3,GRIN1,CACNA1A
9.092e-05	-9.31	ErbB4 signaling events	Pathway Interaction DB	erbb4_pathway	32	3	2226	7	DLG4,GRIN2B,NRG3
9.169e-05	-9.30	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	4	19454	49	GRIN1,GRIN2B,DLG3,DLG4
9.227e-05	-9.29	protein tetramerization	biological process	GO:0051262	92	4	18204	47	KCNC1,GRIN2B,HCN1,GRIN1
9.254e-05	-9.29	Carvedilol Action Pathway	SMPDB pathways	SMP0000367	58	4	1369	7	CACNA1G,CHRM2,CACNA1H,KCNIP2
9.254e-05	-9.29	Labetalol Action Pathway	SMPDB pathways	SMP0000368	58	4	1369	7	CACNA1H,CHRM2,CACNA1G,KCNIP2
9.363e-05	-9.28	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	15	16828	48	NTRK3,GRIK2,GRIN1,KCTD16,GRIA3,CACNA1H,OLFM1,CACNA1A,NRG3,NRXN2,MCTP1,ALK,TENM1,SCN8A,HCN1
9.363e-05	-9.28	functioning	COSMIC cancer mutations	functioning	1803	15	16828	48	ALK,TENM1,SCN8A,HCN1,NRG3,NRXN2,MCTP1,CACNA1H,OLFM1,CACNA1A,NTRK3,GRIN1,GRIK2,GRIA3,KCTD16
9.383e-05	-9.27	secretion by cell	biological process	GO:0032940	420	7	18204	47	SYT7,RIMS2,STXBP5,SYT1,NRXN2,NRXN1,CADPS
9.463e-05	-9.27	Activation of Kainate Receptors upon glutamate binding	REACTOME pathways	R-HSA-451326	32	3	10285	29	DLG3,GRIK2,DLG4
9.521e-05	-9.26	TVDCCALPHA1	prints domains	PR01629	3	2	5227	30	CACNA1H,CACNA1G
9.722e-05	-9.24	imitative learning	biological process	GO:0098596	6	2	18204	47	NRXN1,NRXN2
9.722e-05	-9.24	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	2	18204	47	NRXN2,NRXN1
9.722e-05	-9.24	vocal learning	biological process	GO:0042297	6	2	18204	47	NRXN2,NRXN1
9.908e-05	-9.22	Axon guidance	REACTOME pathways	R-HSA-422475	549	8	10285	29	CACNA1H,GRIN2B,CACNA1G,DLG3,DLG4,NRG3,GRIN1,SCN8A
9.909e-05	-9.22	Lidocaine (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000328	59	4	1369	7	CACNA1H,CHRM2,CACNA1G,KCNIP2
9.986e-05	-9.21	NCAM signaling for neurite out-growth	REACTOME pathways	R-HSA-375165	276	6	10285	29	CACNA1H,GRIN2B,CACNA1G,DLG4,NRG3,GRIN1
1.011e-04	-9.20	SCN5A (sodium voltage-gated channel alpha subunit 5)	protein interactions	6331	36	3	19454	49	FGF12,DLG4,DLG3
1.027e-04	-9.18	glutamate-gated calcium ion channel activity	molecular function	GO:0022849	6	2	18094	48	GRIN1,GRIN2B
1.085e-04	-9.13	positive regulation of synaptic transmission, glutamatergic	biological process	GO:0051968	36	3	18204	47	GRIN1,GRIN2B,NRXN1
1.097e-04	-9.12	muscle system process	biological process	GO:0003012	297	6	18204	47	FGF12,KCNIP2,SCN8A,CACNA1G,CACNA1H,KCNMA1
1.131e-04	-9.09	soft_tissue-striated_muscle-rhabdoid_tumour	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdoid_tumour	168	5	16828	48	ALK,DPP10,GABRB2,NTRK3,GRIA3
1.131e-04	-9.09	rhabdoid_tumour	COSMIC cancer mutations	rhabdoid_tumour	168	5	16828	48	GRIA3,GABRB2,NTRK3,DPP10,ALK
1.141e-04	-9.08	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	18	16828	48	GRM7,SYT1,CACNA1A,GRID2,CELF4,KCNT1,KCTD16,GRIA3,GABRB2,PDE2A,ALK,TENM1,GABRD,HCN1,FGF12,NRG3,GABBR2,MCTP1
1.227e-04	-9.01	regulation of neurotransmitter transport	biological process	GO:0051588	99	4	18204	47	STXBP5,RIMS2,MCTP1,SYT1
1.277e-04	-8.97	mRNA splice site recognition	biological process	GO:0006376	38	3	18204	47	CELF5,CELF2,CELF4
1.342e-04	-8.92	dense core granule membrane	cellular component	GO:0032127	7	2	19108	49	STXBP5,CADPS
1.359e-04	-8.90	observational learning	biological process	GO:0098597	7	2	18204	47	NRXN2,NRXN1
1.359e-04	-8.90	spontaneous neurotransmitter secretion	biological process	GO:0061669	7	2	18204	47	RIMS2,SYT1
1.362e-04	-8.90	regulation of monoatomic cation transmembrane transport	biological process	GO:1904062	309	6	18204	47	GRIN1,FGF12,KCNC1,GRIN2B,DPP10,KCNIP2
1.366e-04	-8.90	cellular response to stimulus	biological process	GO:0051716	6307	29	18204	47	NRG3,SYT1,HCN1,NRXN2,GPR85,OLFM1,GRIK2,ALK,CHRM2,FGF12,GABBR2,DLG4,GRM7,CELF4,CACNA1H,GRIN1,NTRK3,KCNIP2,GRIA3,KCNC1,GRID2,RIMS2,PDE2A,GABRB2,GRIN2B,MCTP1,CACNA1A,ASIC2,TENM1
1.407e-04	-8.87	gallbladder	COSMIC cancer mutations	gallbladder	2821	19	16828	48	GRIK2,NTRK3,GRID2,GRIA3,OLFM1,CACNA1H,CSMD2,CACNA1A,NRG3,DPP10,MCTP1,PDE2A,CHRM2,ALK,TENM1,CNTN5,HCN1,SCN8A,CACNA1G
1.407e-04	-8.87	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	19	16828	48	TENM1,CNTN5,HCN1,CACNA1G,SCN8A,PDE2A,ALK,CHRM2,MCTP1,NRG3,DPP10,CSMD2,CACNA1A,OLFM1,CACNA1H,GRIA3,GRIK2,NTRK3,GRID2
1.418e-04	-8.86	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	4	18094	48	GRIK2,GRIN2B,GRIA3,GRIN1
1.435e-04	-8.85	NMDA glutamate receptor activity	molecular function	GO:0004972	7	2	18094	48	GRIN1,GRIN2B
1.468e-04	-8.83	Post NMDA receptor activation events	REACTOME pathways	R-HSA-438064	37	3	10285	29	GRIN2B,DLG4,GRIN1
1.490e-04	-8.81	calcium ion import	biological process	GO:0070509	40	3	18204	47	CACNA1H,CACNA1A,CACNA1G
1.497e-04	-8.81	LIN7B (lin-7 homolog B, crumbs cell polarity complex component)	protein interactions	64130	41	3	19454	49	GRIN2B,DLG4,GRIK2
1.577e-04	-8.75	brainstem	COSMIC cancer mutations	brainstem	3102	20	16828	48	MCTP1,GABBR2,NRG3,FGF12,HCN1,CNTN5,GABRD,TENM1,ALK,PDE2A,GABRB2,KCTD16,GRIA3,KCNT1,CELF4,GRID2,CACNA1A,SYT1,GRM7,CACNA1H
1.582e-04	-8.75	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	5	19454	49	NRXN1,DLG3,NRXN2,GRIK2,DLG4
1.598e-04	-8.74	NrCAM interactions	REACTOME pathways	R-HSA-447038	7	2	10285	29	DLG4,DLG3
1.620e-04	-8.73	cognition	biological process	GO:0050890	319	6	18204	47	GRIN1,CSMD1,NRXN2,DLG4,NRXN1,GRIN2B
1.658e-04	-8.70	Potassium Channels	REACTOME pathways	R-HSA-1296071	100	4	10285	29	HCN1,GABBR2,KCNC1,KCNMA1
1.680e-04	-8.69	endocytic vesicle membrane	cellular component	GO:0030666	203	5	19108	49	DLG4,SYT7,GRIA3,SYT1,CHRM2
1.693e-04	-8.68	protein localization to membrane	biological process	GO:0072657	462	7	18204	47	GRIK2,DLG4,NRXN2,DPP10,DLG3,NRXN1,GPHN
1.745e-04	-8.65	DLG3 (discs large MAGUK scaffold protein 3)	protein interactions	1741	111	4	19454	49	DLG4,GRIK2,GRIN1,GRIN2B
1.779e-04	-8.63	postsynapse organization	biological process	GO:0099173	109	4	18204	47	GPHN,NRXN1,NRXN2,DLG4
1.786e-04	-8.63	regulation of monoatomic ion transport	biological process	GO:0043269	466	7	18204	47	DPP10,ASIC2,GRIN1,KCNIP2,KCNC1,GRIN2B,FGF12
1.801e-04	-8.62	calcium ion transmembrane transport	biological process	GO:0070588	205	5	18204	47	GRIN1,CACNA1H,CACNA1G,GRIN2B,CACNA1A
1.851e-04	-8.59	regulation of synaptic vesicle exocytosis	biological process	GO:2000300	43	3	18204	47	SYT1,STXBP5,RIMS2
1.865e-04	-8.59	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	18	16828	48	GABRA1,NRG3,NRXN2,MCTP1,PDE2A,ALK,TENM1,HCN1,CNTN5,SCN8A,GRIN1,GRIK2,NTRK3,KCTD16,GRIA3,OLFM1,CACNA1H,CACNA1A
1.870e-04	-8.58	voltage-gated calcium channel activity	molecular function	GO:0005245	42	3	18094	48	CACNA1A,CACNA1G,CACNA1H
1.910e-04	-8.56	glutamate binding	molecular function	GO:0016595	8	2	18094	48	GRIN1,GRIN2B
1.927e-04	-8.55	regulation of heart contraction	biological process	GO:0008016	208	5	18204	47	CACNA1H,CHRM2,CACNA1G,CELF2,KCNIP2
1.934e-04	-8.55	axon terminus	cellular component	GO:0043679	112	4	19108	49	CHRM2,KCNC1,GRIK2,GRIN1
1.983e-04	-8.53	receptor localization to synapse	biological process	GO:0097120	44	3	18204	47	DLG4,GPHN,DLG3
1.993e-04	-8.52	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	38	16828	48	GRID2,NTRK3,KCNT1,GRM7,STXBP5,GRIN2B,SYT1,CSMD2,CADPS,NRG3,GABRA1,MCTP1,KCNC1,ALK,PDE2A,HCN1,SCN8A,FAM131A,RALYL,CELF4,GRIN1,GRIK2,KCTD16,CELF2,OLFM1,RIMS2,DPP10,GABBR2,NRXN1,NRXN2,CHRM2,GABRB2,FGF12,CNTN5,KCNMA1,CACNA1G,GABRD,CELF5
2.027e-04	-8.50	Cocaine Action Pathway	SMPDB pathways	SMP0000395	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Procaine Action Pathway	SMPDB pathways	SMP0000402	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Remifentanil Action Pathway	SMPDB pathways	SMP0000416	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Oxymorphone Action Pathway	SMPDB pathways	SMP0000412	26	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.027e-04	-8.50	Levobupivacaine Action Pathway	SMPDB pathways	SMP0000397	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Proparacaine Action Pathway	SMPDB pathways	SMP0000403	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Hydromorphone Action Pathway	SMPDB pathways	SMP0000410	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Oxybuprocaine Action Pathway	SMPDB pathways	SMP0000400	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Chloroprocaine Action Pathway	SMPDB pathways	SMP0000394	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Methadyl Acetate Action Pathway	SMPDB pathways	SMP0000678	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Alfentanil Action Pathway	SMPDB pathways	SMP0000413	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Mepivacaine Action Pathway	SMPDB pathways	SMP0000399	26	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.027e-04	-8.50	Diphenoxylate Action Pathway	SMPDB pathways	SMP0000675	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Dimethylthiambutene Action Pathway	SMPDB pathways	SMP0000680	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Tramadol Action Action Pathway	SMPDB pathways	SMP0000671	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Levallorphan Action Pathway	SMPDB pathways	SMP0000683	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Levomethadyl Acetate Action Action Pathway	SMPDB pathways	SMP0000677	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Pentazocine Action Pathway	SMPDB pathways	SMP0000686	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Anileridine Action Pathway	SMPDB pathways	SMP0000674	26	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.027e-04	-8.50	3-Methylthiofentanyl Action Pathway	SMPDB pathways	SMP0000679	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Hydrocodone Action Pathway	SMPDB pathways	SMP0000411	26	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.027e-04	-8.50	Dibucaine Action Pathway	SMPDB pathways	SMP0000396	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Fentanyl Action Pathway	SMPDB pathways	SMP0000415	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Naloxone Action Pathway	SMPDB pathways	SMP0000688	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Prilocaine Action Pathway	SMPDB pathways	SMP0000401	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Benzocaine Action Pathway	SMPDB pathways	SMP0000392	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Ropivacaine Action Pathway	SMPDB pathways	SMP0000404	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Sufentanil Action Pathway	SMPDB pathways	SMP0000417	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Oxycodone Action Pathway	SMPDB pathways	SMP0000409	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Bupivacaine Action Pathway	SMPDB pathways	SMP0000393	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Carfentanil Action Pathway	SMPDB pathways	SMP0000414	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Ketobemidone Action Pathway	SMPDB pathways	SMP0000690	26	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.027e-04	-8.50	Dezocine Action Pathway	SMPDB pathways	SMP0000676	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Naltrexone Action Pathway	SMPDB pathways	SMP0000687	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Dihydromorphine Action Pathway	SMPDB pathways	SMP0000689	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Escitalopram Action Pathway	SMPDB pathways	SMP0000425	26	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.027e-04	-8.50	Buprenorphine Action Pathway	SMPDB pathways	SMP0000684	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Propoxyphene Action Pathway	SMPDB pathways	SMP0000672	26	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.027e-04	-8.50	Ethylmorphine Action Pathway	SMPDB pathways	SMP0000681	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.027e-04	-8.50	Alvimopan Action Pathway	SMPDB pathways	SMP0000685	26	3	1369	7	GRIN1,CACNA1A,KCNIP2
2.027e-04	-8.50	Levorphanol Action Pathway	SMPDB pathways	SMP0000673	26	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.044e-04	-8.50	regulation of regulated secretory pathway	biological process	GO:1903305	113	4	18204	47	RIMS2,STXBP5,SYT7,SYT1
2.085e-04	-8.48	voltage-gated calcium channel complex	cellular component	GO:0005891	45	3	19108	49	CACNA1A,CACNA1G,CACNA1H
2.117e-04	-8.46	Neurotransmitter_ion_chnl_CS	interpro domains	IPR018000	43	3	18521	50	GABRD,GABRB2,GABRA1
2.121e-04	-8.46	cardiac muscle cell action potential involved in contraction	biological process	GO:0086002	45	3	18204	47	SCN8A,CACNA1G,FGF12
2.212e-04	-8.42	NETO1 (neuropilin and tolloid like 1)	protein interactions	81832	9	2	19454	49	GRIN2B,GRIN1
2.215e-04	-8.42	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	15	16828	48	GRIK2,NTRK3,GRID2,GRIN2B,RIMS2,CSMD2,GRM7,STXBP5,NRXN1,NRXN2,CNTN5,FGF12,HCN1,KCNMA1,PDE2A
2.241e-04	-8.40	larynx	COSMIC cancer mutations	larynx	1948	15	16828	48	HCN1,CNTN5,FGF12,KCNMA1,PDE2A,NRXN1,NRXN2,RIMS2,GRIN2B,CSMD2,GRM7,STXBP5,GRIK2,NTRK3,GRID2
2.252e-04	-8.40	GRIA1 (glutamate ionotropic receptor AMPA type subunit 1)	protein interactions	2890	47	3	19454	49	GRIK2,GRIA3,GRID2
2.268e-04	-8.39	Neurotrans-gated_channel_TM	interpro domains	IPR006029	44	3	18521	50	GABRD,GABRA1,GABRB2
2.275e-04	-8.39	Nalbuphine Action Pathway	SMPDB pathways	SMP0000691	27	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.275e-04	-8.39	Desipramine Action Pathway	SMPDB pathways	SMP0000423	27	3	1369	7	GRIN1,KCNIP2,CACNA1A
2.293e-04	-8.38	NMDA selective glutamate receptor complex	cellular component	GO:0017146	9	2	19108	49	GRIN1,GRIN2B
2.322e-04	-8.37	spontaneous synaptic transmission	biological process	GO:0098814	9	2	18204	47	SYT1,RIMS2
2.322e-04	-8.37	receptor diffusion trapping	biological process	GO:0098953	9	2	18204	47	GPHN,DLG4
2.322e-04	-8.37	postsynaptic neurotransmitter receptor diffusion trapping	biological process	GO:0098970	9	2	18204	47	DLG4,GPHN
2.322e-04	-8.37	neurotransmitter receptor diffusion trapping	biological process	GO:0099628	9	2	18204	47	DLG4,GPHN
2.400e-04	-8.33	Neur_chan_memb	pfam domains	PF02932	44	3	17795	49	GABRB2,GABRD,GABRA1
2.425e-04	-8.32	Neuro_actylchol_rec	interpro domains	IPR038050	45	3	18521	50	GABRB2,GABRA1,GABRD
2.425e-04	-8.32	Neuro-gated_channel_TM_sf	interpro domains	IPR036719	45	3	18521	50	GABRB2,GABRA1,GABRD
2.425e-04	-8.32	Neur_chan_lig-bd_sf	interpro domains	IPR036734	45	3	18521	50	GABRD,GABRA1,GABRB2
2.425e-04	-8.32	Neur_chan_lig-bd	interpro domains	IPR006202	45	3	18521	50	GABRB2,GABRA1,GABRD
2.425e-04	-8.32	Neur_channel	interpro domains	IPR006201	45	3	18521	50	GABRD,GABRA1,GABRB2
2.442e-04	-8.32	GABAARECEPTR	prints domains	PR00253	22	3	5227	30	GABRB2,GABRD,GABRA1
2.455e-04	-8.31	pre-mRNA binding	molecular function	GO:0036002	46	3	18094	48	CELF2,CELF4,CELF5
2.500e-04	-8.29	response to mechanical stimulus	biological process	GO:0009612	220	5	18204	47	NRXN2,ASIC2,PDE2A,NRXN1,KCNC1
2.540e-04	-8.28	VDCCAlpha1	interpro domains	IPR002077	9	2	18521	50	CACNA1G,CACNA1A
2.543e-04	-8.28	Lidocaine (Local Anaesthetic) Action Pathway	SMPDB pathways	SMP0000398	28	3	1369	7	CACNA1A,KCNIP2,GRIN1
2.567e-04	-8.27	Neur_chan_LBD	pfam domains	PF02931	45	3	17795	49	GABRB2,GABRD,GABRA1
2.641e-04	-8.24	positive regulation of transport	biological process	GO:0051050	844	9	18204	47	SYT7,GRIN1,STXBP5,TENM1,FGF12,SYT1,KCNIP2,CADPS,KCNC1
2.653e-04	-8.23	Taste transduction	KEGG pathways	hsa04742	82	4	7161	28	GABRA1,ASIC2,CACNA1A,GABBR2
2.653e-04	-8.23	Taste transduction	KEGG pathways	ko04742	82	4	7161	28	CACNA1A,GABBR2,GABRA1,ASIC2
2.694e-04	-8.22	NEUROTR_ION_CHANNEL	prosite domains	PS00236	43	3	12186	36	GABRA1,GABRB2,GABRD
2.728e-04	-8.21	regulation of cellular component organization	biological process	GO:0051128	2455	16	18204	47	GRID2,NRG3,NRXN1,NTRK3,SYT1,PDE2A,OLFM1,RIMS2,STXBP5,GRIN2B,ALK,DLG4,MCTP1,TENM1,ASIC2,SYT7
2.745e-04	-8.20	regulation of biological process	biological process	GO:0050789	12079	42	18204	47	MCTP1,CACNA1G,GRIN2B,GABRD,ASIC2,CACNA1A,CELF2,TENM1,KCNIP2,NTRK3,GRID2,KCNC1,GRIA3,GABRB2,GABRA1,DLG3,RIMS2,STXBP5,PDE2A,GABBR2,FGF12,DLG4,ALK,CHRM2,CADPS,CACNA1H,GRIN1,SYT7,GRM7,DPP10,CELF4,SYT1,NRXN2,HCN1,CELF5,NRG3,NRXN1,GRIK2,KCNMA1,KCTD16,OLFM1,GPR85
2.761e-04	-8.19	human chrXq25	chromosome location	human chrXq25	13	2	26134	50	TENM1,GRIA3
2.761e-04	-8.19	ASIC3 (acid sensing ion channel subunit 3)	protein interactions	9311	10	2	19454	49	DLG4,ASIC2
2.797e-04	-8.18	C2DOMAIN	prints domains	PR00360	23	3	5227	30	MCTP1,SYT1,SYT7
2.830e-04	-8.17	Codeine Action Pathway	SMPDB pathways	SMP0000405	29	3	1369	7	KCNIP2,CACNA1A,GRIN1
2.851e-04	-8.16	Phenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000327	77	4	1369	7	KCNIP2,CACNA1H,CHRM2,CACNA1G
2.856e-04	-8.16	Guanylate Kinase phosphate binding domain	gene3d domains	3.30.63.10	8	2	14470	47	DLG4,DLG3
2.898e-04	-8.15	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	2	18204	47	NRXN1,NRXN2
2.898e-04	-8.15	postsynaptic density assembly	biological process	GO:0097107	10	2	18204	47	NRXN1,NRXN2
2.898e-04	-8.15	postsynaptic membrane assembly	biological process	GO:0097104	10	2	18204	47	NRXN1,NRXN2
2.903e-04	-8.14	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	41	16828	48	DLG3,SYT7,GABBR2,KCNIP2,NRXN2,NRXN1,CHRM2,GABRB2,GPR85,KCNMA1,CACNA1G,CNTN5,CELF5,GABRD,DLG4,RALYL,GRIN1,GRIK2,CELF4,GRIA3,KCTD16,CACNA1H,OLFM1,RIMS2,NRG3,CADPS,GABRA1,MCTP1,KCNC1,ALK,PDE2A,SCN8A,HCN1,NTRK3,GRID2,KCNT1,GRM7,STXBP5,GRIN2B,CACNA1A,CSMD2
2.903e-04	-8.14	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	41	16828	48	GRIK2,CELF4,GRIN1,DLG4,RALYL,KCTD16,GRIA3,CACNA1H,OLFM1,RIMS2,SYT7,DLG3,NRXN2,NRXN1,GABBR2,KCNIP2,GABRB2,CHRM2,CELF5,GABRD,KCNMA1,GPR85,CACNA1G,CNTN5,NTRK3,GRID2,KCNT1,STXBP5,GRM7,CSMD2,GRIN2B,CACNA1A,NRG3,CADPS,GABRA1,KCNC1,MCTP1,PDE2A,ALK,SCN8A,HCN1
3.008e-04	-8.11	neuron development	biological process	GO:0048666	859	9	18204	47	NRXN1,KCNIP2,ALK,HCN1,DLG4,CNTN5,TENM1,GRM7,GABRB2
3.024e-04	-8.10	protein-containing complex	cellular component	GO:0032991	6542	29	19108	49	GABRA1,STXBP5,CACNA1H,CACNA1G,GABBR2,GRID2,ALK,CELF4,NRXN2,CELF2,KCNIP2,GRIK2,GRIN1,SCN8A,KCNMA1,KCTD16,DLG4,GRIN2B,HCN1,NTRK3,GABRD,DPP10,GRIA3,KCNC1,GRM7,CACNA1A,DLG3,GABRB2,CELF5
3.032e-04	-8.10	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	44	16828	48	GRM7,STXBP5,CACNA1A,GRIN2B,SYT1,CSMD2,NTRK3,GRID2,KCNT1,ALK,PDE2A,HCN1,SCN8A,TENM1,CADPS,GABRA1,NRG3,MCTP1,KCNC1,CELF2,CACNA1H,RIMS2,RALYL,FAM131A,DLG4,GRIN1,CELF4,KCTD16,GRIA3,CHRM2,GABRB2,CNTN5,FGF12,GPR85,CACNA1G,KCNMA1,GABRD,CELF5,DPP10,DLG3,SYT7,GABBR2,NRXN1,NRXN2
3.069e-04	-8.09	cervix	COSMIC cancer mutations	cervix	11793	44	16828	48	CACNA1A,CSMD2,GRM7,SCN8A,TENM1,ALK,PDE2A,MCTP1,CADPS,GABRA1,RIMS2,GRIA3,FAM131A,GRIN1,CELF4,KCNMA1,GPR85,CACNA1G,GABRD,GABBR2,NRXN2,NRXN1,GRIN2B,SYT1,STXBP5,KCNT1,GRID2,NTRK3,HCN1,KCNC1,NRG3,CACNA1H,CELF2,KCTD16,RALYL,DLG4,FGF12,CNTN5,CELF5,CHRM2,GABRB2,DPP10,SYT7,DLG3
3.079e-04	-8.09	cardiac muscle cell contraction	biological process	GO:0086003	51	3	18204	47	FGF12,CACNA1G,SCN8A
3.137e-04	-8.07	Imipramine Action Pathway	SMPDB pathways	SMP0000422	30	3	1369	7	GRIN1,CACNA1A,KCNIP2
3.169e-04	-8.06	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	5	19454	49	DLG3,KCNC1,RALYL,GRIN2B,GRIN1
3.219e-04	-8.04	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	48	GRM7,CACNA1A,CSMD2,CADPS,GABRA1,MCTP1,ALK,PDE2A,SCN8A,TENM1,FAM131A,GRIK2,CELF4,GRIN1,GRIA3,OLFM1,RIMS2,GABBR2,NRXN2,NRXN1,GPR85,KCNMA1,CACNA1G,GABRD,GRID2,NTRK3,KCNT1,STXBP5,GRIN2B,SYT1,GPHN,NRG3,KCNC1,HCN1,DLG4,RALYL,KCTD16,CACNA1H,CELF2,DPP10,DLG3,SYT7,KCNIP2,CHRM2,GABRB2,FGF12,CNTN5,CELF5
3.220e-04	-8.04	LIN7A (lin-7 homolog A, crumbs cell polarity complex component)	protein interactions	8825	53	3	19454	49	DLG3,DLG4,GRIN2B
3.322e-04	-8.01	regulation of vesicle-mediated transport	biological process	GO:0060627	516	7	18204	47	SYT7,DLG4,MCTP1,SYT1,CADPS,STXBP5,RIMS2
3.337e-04	-8.01	amino acid binding	molecular function	GO:0016597	51	3	18094	48	GRM7,GRIN2B,GRIN1
3.342e-04	-8.00	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	16	16828	48	NRG3,GABRA1,MCTP1,NRXN2,ALK,HCN1,SCN8A,TENM1,GRIK2,GRIN1,NTRK3,GRIA3,KCTD16,OLFM1,CACNA1H,CACNA1A
3.352e-04	-8.00	caecum	COSMIC cancer mutations	caecum	14248	48	16828	48	STXBP5,GRIN2B,SYT1,GRID2,NTRK3,KCNT1,HCN1,NRG3,GPHN,KCNC1,CACNA1H,CELF2,RALYL,DLG4,KCTD16,GABRB2,CHRM2,CELF5,FGF12,CNTN5,DLG3,SYT7,DPP10,KCNIP2,GRM7,CSMD2,CACNA1A,PDE2A,ALK,TENM1,SCN8A,CADPS,GABRA1,MCTP1,OLFM1,RIMS2,GRIK2,CELF4,GRIN1,FAM131A,GRIA3,GABRD,KCNMA1,CACNA1G,GPR85,NRXN2,NRXN1,GABBR2
3.369e-04	-8.00	Caskin1 (CASK interacting protein 1)	protein interactions	140722	11	2	19454	49	SYT1,NRXN2
3.369e-04	-8.00	KCTD16 (potassium channel tetramerization domain containing 16)	protein interactions	57528	11	2	19454	49	KCTD16,GABBR2
3.390e-04	-7.99	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	32	16828	48	KCNT1,NTRK3,GRID2,GRIN2B,CSMD2,GRM7,KCNC1,GABRA1,NRG3,CADPS,SCN8A,HCN1,ALK,PDE2A,KCTD16,GRIA3,FAM131A,DLG4,GRIK2,GRIN1,RIMS2,CELF2,KCNIP2,NRXN2,NRXN1,SYT7,KCNMA1,CACNA1G,CNTN5,GABRD,CHRM2,GABRB2
3.451e-04	-7.97	social behavior	biological process	GO:0035176	53	3	18204	47	NRXN1,NRXN2,DLG4
3.451e-04	-7.97	biological process involved in intraspecies interaction between organisms	biological process	GO:0051703	53	3	18204	47	NRXN1,DLG4,NRXN2
3.466e-04	-7.97	Fluoxetine Action Pathway	SMPDB pathways	SMP0000426	31	3	1369	7	GRIN1,KCNIP2,CACNA1A
3.591e-04	-7.93	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	biological process	GO:0007188	238	5	18204	47	CHRM2,PDE2A,GRM7,RIMS2,GABBR2
3.611e-04	-7.93	neuron differentiation	biological process	GO:0030182	1081	10	18204	47	HCN1,DLG4,CNTN5,GRID2,NRXN1,ALK,KCNIP2,GABRB2,TENM1,GRM7
3.621e-04	-7.92	C2	pfam domains	PF00168	123	4	17795	49	MCTP1,SYT7,RIMS2,SYT1
3.733e-04	-7.89	acetylcholine receptor binding	molecular function	GO:0033130	11	2	18094	48	NRXN1,DLG4
3.733e-04	-7.89	glycine binding	molecular function	GO:0016594	11	2	18094	48	GRIN2B,GRIN1
3.740e-04	-7.89	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	7	16828	48	CELF4,CADPS,NRG3,GRID2,RALYL,GABBR2,CSMD2
3.803e-04	-7.87	exocytosis	biological process	GO:0006887	241	5	18204	47	CADPS,STXBP5,RIMS2,SYT7,SYT1
3.816e-04	-7.87	Nicotine Action Pathway	SMPDB pathways	SMP0000431	32	3	1369	7	GRIN1,CACNA1A,KCNIP2
3.816e-04	-7.87	Methadone Action Pathway	SMPDB pathways	SMP0000408	32	3	1369	7	KCNIP2,CACNA1A,GRIN1
3.816e-04	-7.87	Citalopram Action Pathway	SMPDB pathways	SMP0000424	32	3	1369	7	GRIN1,KCNIP2,CACNA1A
3.851e-04	-7.86	regulation of alternative mRNA splicing, via spliceosome	biological process	GO:0000381	55	3	18204	47	CELF4,CELF2,CELF5
3.868e-04	-7.86	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	2	18521	50	ALK,NTRK3
3.992e-04	-7.83	chloride channel complex	cellular component	GO:0034707	56	3	19108	49	GABRD,GABRB2,GABRA1
4.142e-04	-7.79	Neurotransmitter-gated ion-channel ligand-binding domain	gene3d domains	2.70.170.10	45	3	14470	47	GABRB2,GABRA1,GABRD
4.142e-04	-7.79	Neurotransmitter-gated ion-channel transmembrane domain	gene3d domains	1.20.58.390	45	3	14470	47	GABRB2,GABRD,GABRA1
4.177e-04	-7.78	secretion	biological process	GO:0046903	536	7	18204	47	SYT1,NRXN2,NRXN1,CADPS,SYT7,STXBP5,RIMS2
4.236e-04	-7.77	auditory behavior	biological process	GO:0031223	12	2	18204	47	NRXN1,NRXN2
4.236e-04	-7.77	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	2	18204	47	GPHN,DLG4
4.236e-04	-7.77	excitatory chemical synaptic transmission	biological process	GO:0098976	12	2	18204	47	GRIN1,GRIN2B
4.350e-04	-7.74	ARHGAP32 (Rho GTPase activating protein 32)	protein interactions	9743	141	4	19454	49	GPHN,DLG4,NTRK3,GRIN2B
4.400e-04	-7.73	calcium-dependent phospholipid binding	molecular function	GO:0005544	56	3	18094	48	SYT7,SYT1,MCTP1
4.454e-04	-7.72	signal transduction	biological process	GO:0007165	4637	23	18204	47	PDE2A,RIMS2,GRID2,GRIA3,KCNIP2,NTRK3,TENM1,ASIC2,GRIN2B,MCTP1,OLFM1,GPR85,GRIK2,NRG3,NRXN2,CELF4,GRM7,GRIN1,CHRM2,ALK,DLG4,GABBR2,FGF12
4.579e-04	-7.69	calcium ion transport	biological process	GO:0006816	251	5	18204	47	CACNA1A,GRIN2B,CACNA1G,CACNA1H,GRIN1
4.590e-04	-7.69	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	2	12186	36	ALK,NTRK3
4.590e-04	-7.69	G_PROTEIN_RECEP_F3_3	prosite domains	PS00981	11	2	12186	36	GABBR2,GRM7
4.666e-04	-7.67	cell-cell adhesion	biological process	GO:0098609	546	7	18204	47	TENM1,DLG3,GRID2,NRXN1,NRXN2,DLG4,CNTN5
4.927e-04	-7.62	regulation of secretion by cell	biological process	GO:1903530	551	7	18204	47	MCTP1,SYT1,CADPS,SYT7,STXBP5,GRM7,RIMS2
4.978e-04	-7.61	transmission of nerve impulse	biological process	GO:0019226	60	3	18204	47	GRIK2,HCN1,SCN8A
4.998e-04	-7.60	detection of calcium ion	biological process	GO:0005513	13	2	18204	47	KCNIP2,SYT1
4.998e-04	-7.60	positive regulation of calcium ion-dependent exocytosis	biological process	GO:0045956	13	2	18204	47	SYT7,SYT1
4.998e-04	-7.60	postsynaptic specialization assembly	biological process	GO:0098698	13	2	18204	47	NRXN2,NRXN1
4.998e-04	-7.60	cellular response to potassium ion	biological process	GO:0035865	13	2	18204	47	CACNA1H,DLG4
5.053e-04	-7.59	GABA receptor activation	REACTOME pathways	R-HSA-977443	56	3	10285	29	GABRA1,GABBR2,GABRB2
5.143e-04	-7.57	synaptic vesicle cycle	biological process	GO:0099504	144	4	18204	47	SYT7,SYT1,CADPS,RIMS2
5.143e-04	-7.57	regulated exocytosis	biological process	GO:0045055	144	4	18204	47	RIMS2,CADPS,SYT1,SYT7
5.276e-04	-7.55	GABA-gated chloride ion channel activity	molecular function	GO:0022851	13	2	18094	48	GABRB2,GABRA1
5.368e-04	-7.53	scalp	COSMIC cancer mutations	scalp	2110	15	16828	48	NRXN1,GABBR2,ALK,CHRM2,GPR85,GRIK2,GRID2,NTRK3,KCNT1,KCTD16,OLFM1,STXBP5,CSMD2,RIMS2,SYT1
5.418e-04	-7.52	adult behavior	biological process	GO:0030534	146	4	18204	47	ALK,NRXN1,FGF12,NRXN2
5.482e-04	-7.51	regulation of postsynaptic membrane neurotransmitter receptor levels	biological process	GO:0099072	62	3	18204	47	DLG4,DLG3,GPHN
5.547e-04	-7.50	GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2)	protein interactions	2977	14	2	19454	49	DLG4,DLG3
5.547e-04	-7.50	SYT5 (synaptotagmin 5)	protein interactions	6861	14	2	19454	49	SYT1,NRXN1
5.619e-04	-7.48	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	15	16828	48	CELF4,GRID2,RALYL,CSMD2,GRIN2B,SYT1,OLFM1,GRM7,NRXN2,MCTP1,GABBR2,NRG3,FGF12,HCN1,ALK
5.619e-04	-7.48	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	15	16828	48	HCN1,FGF12,ALK,GABBR2,MCTP1,NRXN2,NRG3,SYT1,GRIN2B,CSMD2,GRM7,OLFM1,RALYL,GRID2,CELF4
5.821e-04	-7.45	mechanosensory behavior	biological process	GO:0007638	14	2	18204	47	NRXN1,NRXN2
5.874e-04	-7.44	GABA A receptor activation	REACTOME pathways	R-HSA-977441	13	2	10285	29	GABRB2,GABRA1
5.885e-04	-7.44	peptide binding	molecular function	GO:0042277	258	5	18094	48	KCNIP2,GRIN1,CACNA1A,GRIN2B,GRIA3
5.980e-04	-7.42	Calcium signaling pathway	KEGG pathways	ko04020	181	5	7161	28	CACNA1G,GRIN1,CACNA1H,CACNA1A,CHRM2
5.980e-04	-7.42	Calcium signaling pathway	KEGG pathways	hsa04020	181	5	7161	28	CACNA1A,CHRM2,CACNA1H,CACNA1G,GRIN1
6.100e-04	-7.40	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	20	16828	48	CACNA1A,SYT1,RIMS2,CSMD2,GRIK2,CELF4,GRIN1,GRID2,GRIA3,ALK,CNTN5,KCNMA1,CELF5,GABRA1,CADPS,NRG3,MCTP1,NRXN1,KCNC1,NRXN2
6.107e-04	-7.40	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	23	16828	48	NTRK3,CACNA1A,GRIN2B,CSMD2,GRM7,MCTP1,GABRA1,CADPS,NRG3,HCN1,TENM1,DLG4,FAM131A,GRIK2,RIMS2,CACNA1H,DPP10,DLG3,FGF12,CNTN5,CACNA1G,KCNMA1,CHRM2
6.146e-04	-7.39	GNG2 (G protein subunit gamma 2)	protein interactions	54331	66	3	19454	49	KCTD16,CACNA1H,CHRM2
6.216e-04	-7.38	generation of neurons	biological process	GO:0048699	1158	10	18204	47	TENM1,GRM7,GABRB2,GRID2,NRXN1,KCNIP2,ALK,DLG4,HCN1,CNTN5
6.298e-04	-7.37	positive regulation of synapse assembly	biological process	GO:0051965	65	3	18204	47	ASIC2,GRID2,NRXN1
6.366e-04	-7.36	GPCR_3	interpro domains	IPR000337	14	2	18521	50	GABBR2,GRM7
6.366e-04	-7.36	Neurexin-like	interpro domains	IPR003585	14	2	18521	50	NRXN2,NRXN1
6.366e-04	-7.36	GPCR_3_CS	interpro domains	IPR017979	14	2	18521	50	GABBR2,GRM7
6.388e-04	-7.36	SDCBP (syndecan binding protein)	protein interactions	6386	422	6	19454	49	NRXN1,CADPS,GRM7,GRIA3,GRIK2,PDE2A
6.547e-04	-7.33	distal axon	cellular component	GO:0150034	273	5	19108	49	CHRM2,KCNC1,OLFM1,GRIK2,GRIN1
6.557e-04	-7.33	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	28	16828	48	DPP10,NRXN2,GABBR2,GABRB2,FGF12,CACNA1G,GRIK2,CELF4,RALYL,DLG4,GRIA3,KCTD16,CACNA1H,RIMS2,NRG3,CADPS,MCTP1,ALK,TENM1,HCN1,GRID2,NTRK3,KCNT1,STXBP5,GRM7,CSMD2,CACNA1A,GRIN2B
6.621e-04	-7.32	vesicle-mediated transport in synapse	biological process	GO:0099003	154	4	18204	47	CADPS,RIMS2,SYT7,SYT1
6.706e-04	-7.31	protein heterotetramerization	biological process	GO:0051290	15	2	18204	47	GRIN1,GRIN2B
6.846e-04	-7.29	blood circulation	biological process	GO:0008015	418	6	18204	47	SCN8A,CACNA1G,FGF12,KCNMA1,ASIC2,PDE2A
7.064e-04	-7.26	main axon	cellular component	GO:0044304	68	3	19108	49	KCNC1,SCN8A,DLG4
7.292e-04	-7.22	TAMALIN (trafficking regulator and scaffold protein tamalin)	protein interactions	160622	16	2	19454	49	GABBR2,DLG4
7.292e-04	-7.22	SYT4 (synaptotagmin 4)	protein interactions	6860	16	2	19454	49	NRXN1,SYT1
7.301e-04	-7.22	DLGAP4 (DLG associated protein 4)	protein interactions	22839	70	3	19454	49	GRIN1,DLG4,DLG3
7.466e-04	-7.20	Morphine Action Pathway	SMPDB pathways	SMP0000406	40	3	1369	7	GRIN1,CACNA1A,KCNIP2
7.565e-04	-7.19	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	48	HCN1,SCN8A,TENM1,ALK,PDE2A,MCTP1,KCNC1,GPHN,NRG3,GABRA1,CADPS,CACNA1A,SYT1,GRIN2B,CSMD2,GRM7,KCNT1,GRID2,NTRK3,FGF12,CNTN5,KCNMA1,CACNA1G,GPR85,GABRD,CELF5,CHRM2,GABBR2,NRXN1,NRXN2,DPP10,SYT7,DLG3,RIMS2,OLFM1,GRIA3,KCTD16,DLG4,RALYL,CELF4,GRIK2
7.651e-04	-7.18	neuron cell-cell adhesion	biological process	GO:0007158	16	2	18204	47	NRXN2,NRXN1
7.688e-04	-7.17	calcium channel complex	cellular component	GO:0034704	70	3	19108	49	CACNA1H,CACNA1A,CACNA1G
7.937e-04	-7.14	Nitric Oxide Signaling Pathway	SMPDB pathways	SMP0063777	9	2	1369	7	GRIN1,DLG4
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	GRIK2,ASIC2,SCN8A,HCN1
8.322e-04	-7.09	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	11	16828	48	GABBR2,GABRA1,HCN1,CELF5,KCNT1,GRIK2,NTRK3,GRID2,GRIN2B,CSMD2,GRM7
8.366e-04	-7.09	Guanylate_kinase_CS	interpro domains	IPR020590	16	2	18521	50	DLG4,DLG3
8.412e-04	-7.08	transport vesicle	cellular component	GO:0030133	437	6	19108	49	STXBP5,MCTP1,SYT7,GRIN1,DLG4,SYT1
8.566e-04	-7.06	regulation of secretion	biological process	GO:0051046	605	7	18204	47	SYT7,SYT1,MCTP1,CADPS,RIMS2,GRM7,STXBP5
8.585e-04	-7.06	ADGRL1 (adhesion G protein-coupled receptor L1)	protein interactions	22859	74	3	19454	49	CACNA1A,DLG3,DLG4
8.746e-04	-7.04	Cocaine addiction	KEGG pathways	ko05030	49	3	7161	28	GRIN1,DLG4,GRIN2B
8.746e-04	-7.04	Cocaine addiction	KEGG pathways	hsa05030	49	3	7161	28	GRIN2B,DLG4,GRIN1
8.991e-04	-7.01	cAMP signaling pathway	KEGG pathways	hsa04024	198	5	7161	28	GRIN1,GRIA3,GRIN2B,CHRM2,GABBR2
8.991e-04	-7.01	cAMP signaling pathway	KEGG pathways	ko04024	198	5	7161	28	GRIN1,GABBR2,GRIN2B,CHRM2,GRIA3
9.137e-04	-7.00	ligand-gated sodium channel activity	molecular function	GO:0015280	17	2	18094	48	GRIK2,ASIC2
9.267e-04	-6.98	KLHL1 (kelch like family member 1)	protein interactions	57626	18	2	19454	49	CACNA1A,CACNA1H
9.466e-04	-6.96	Synaptotagmin	interpro domains	IPR001565	17	2	18521	50	SYT1,SYT7
9.635e-04	-6.94	cytoplasmic vesicle membrane	cellular component	GO:0030659	1230	10	19108	49	CADPS,CHRM2,MCTP1,GABRB2,SYT7,SYT1,GRIA3,GABRA1,STXBP5,DLG4
9.687e-04	-6.94	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	32	16828	48	GABBR2,KCNIP2,NRXN2,DPP10,SYT7,CACNA1G,CNTN5,FGF12,CELF5,GRIA3,KCTD16,RALYL,GRIK2,CELF4,GRIN1,OLFM1,MCTP1,NRG3,GABRA1,CADPS,SCN8A,HCN1,ALK,PDE2A,KCNT1,GRID2,NTRK3,SYT1,GRIN2B,CACNA1A,CSMD2,GRM7
9.921e-04	-6.92	GUANYLATE_KINASE_1	prosite domains	PS00856	16	2	12186	36	DLG4,DLG3
9.936e-04	-6.91	actin-mediated cell contraction	biological process	GO:0070252	76	3	18204	47	FGF12,CACNA1G,SCN8A
1.000e-03	-6.91	NBEA (neurobeachin)	protein interactions	26960	78	3	19454	49	ALK,DLG3,NTRK3
1.018e-03	-6.89	trunk	COSMIC cancer mutations	trunk	3554	20	16828	48	KCNT1,FAM131A,GRIK2,GRID2,NTRK3,RIMS2,GRIN2B,CSMD2,GRM7,MCTP1,GABBR2,NRXN1,NRXN2,DPP10,NRG3,GABRA1,HCN1,CNTN5,FGF12,CELF5
1.019e-03	-6.89	protein localization	biological process	GO:0008104	1954	13	18204	47	CADPS,DLG4,DPP10,ASIC2,NRXN1,GRID2,HCN1,NRXN2,STXBP5,RIMS2,DLG3,GPHN,GRIK2
1.021e-03	-6.89	C2	smart domains	SM00239	122	4	9717	36	MCTP1,SYT1,SYT7,RIMS2
1.034e-03	-6.87	DRD1 (dopamine receptor D1)	protein interactions	1812	19	2	19454	49	DLG4,GRIN1
1.034e-03	-6.87	ANKRD13C (ankyrin repeat domain 13C)	protein interactions	81573	19	2	19454	49	GRIN1,NTRK3
1.046e-03	-6.86	human chr5q34	chromosome location	human chr5q34	25	2	26134	50	GABRB2,GABRA1
1.048e-03	-6.86	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	9	16828	48	GABRA1,GRIK2,NTRK3,GRID2,CHRM2,GABRD,CSMD2,SYT1,GPR85
1.054e-03	-6.86	positive regulation of kinase activity	biological process	GO:0033674	302	5	18204	47	DLG4,NTRK3,DLG3,ALK,TENM1
1.058e-03	-6.85	cellular macromolecule localization	biological process	GO:0070727	1962	13	18204	47	STXBP5,DLG3,RIMS2,GPHN,GRIK2,NRXN1,GRID2,HCN1,NRXN2,DPP10,ASIC2,CADPS,DLG4
1.097e-03	-6.82	vesicle membrane	cellular component	GO:0012506	1251	10	19108	49	SYT1,GABRA1,GRIA3,STXBP5,DLG4,CHRM2,CADPS,SYT7,GABRB2,MCTP1
1.118e-03	-6.80	CACHANNEL	prints domains	PR00167	9	2	5227	30	CACNA1G,CACNA1A
1.142e-03	-6.77	cGMP effects	REACTOME pathways	R-HSA-418457	18	2	10285	29	KCNMA1,PDE2A
1.145e-03	-6.77	syntaxin-1 binding	molecular function	GO:0017075	19	2	18094	48	SYT1,STXBP5
1.156e-03	-6.76	CCPG1 (cell cycle progression 1)	protein interactions	9236	82	3	19454	49	GRIA3,GABRD,NTRK3
1.160e-03	-6.76	C2_domain_sf	interpro domains	IPR035892	171	4	18521	50	SYT1,SYT7,MCTP1,RIMS2
1.181e-03	-6.74	4.1m	smart domains	SM00294	14	2	9717	36	NRXN1,NRXN2
1.198e-03	-6.73	SYT1 (synaptotagmin 1)	protein interactions	6857	83	3	19454	49	SYT1,NRXN1,CACNA1A
1.208e-03	-6.72	cellular process	biological process	GO:0009987	14996	46	18204	47	SYT7,FGF12,CADPS,KCNMA1,OLFM1,GPR85,HCN1,NRXN2,NRG3,CACNA1A,TENM1,CNTN5,GRIN2B,CACNA1G,STXBP5,DLG3,PDE2A,NTRK3,KCNIP2,KCNC1,GRIA3,CACNA1H,GRIN1,DPP10,GRM7,CELF4,GABBR2,DLG4,ALK,CHRM2,GRIK2,KCNT1,GPHN,KCTD16,SYT1,CELF5,NRXN1,GABRD,ASIC2,CELF2,MCTP1,SCN8A,GABRA1,GABRB2,RIMS2,GRID2
1.235e-03	-6.70	cellular component organization	biological process	GO:0016043	5636	25	18204	47	GABRA1,GABRB2,KCNC1,GRID2,KCNIP2,TENM1,CELF2,ASIC2,CNTN5,GRIN2B,OLFM1,GPHN,KCTD16,KCNMA1,HCN1,NRXN2,SYT1,NRXN1,NRG3,CELF5,SYT7,GRIN1,CELF4,GRM7,DLG4
1.266e-03	-6.67	HTR2A (5-hydroxytryptamine receptor 2A)	protein interactions	3356	21	2	19454	49	NTRK3,DLG4
1.282e-03	-6.66	spliceosomal complex assembly	biological process	GO:0000245	83	3	18204	47	CELF2,CELF4,CELF5
1.282e-03	-6.66	cardiac muscle contraction	biological process	GO:0060048	83	3	18204	47	FGF12,CACNA1G,SCN8A
1.293e-03	-6.65	chloride channel activity	molecular function	GO:0005254	81	3	18094	48	GABRD,GABRA1,GABRB2
1.328e-03	-6.62	optic nerve development	biological process	GO:0021554	21	2	18204	47	KCNC1,SCN8A
1.329e-03	-6.62	regulation of multicellular organismal process	biological process	GO:0051239	3113	17	18204	47	CELF2,CELF4,ASIC2,GRIN1,SYT7,CACNA1H,CACNA1G,CHRM2,GRIN2B,DLG4,FGF12,OLFM1,RIMS2,GRIK2,GRID2,NRXN1,KCNIP2
1.336e-03	-6.62	protein-containing complex assembly	biological process	GO:0065003	1279	10	18204	47	GRIN1,CELF4,KCTD16,CELF2,SYT1,HCN1,DLG4,CELF5,KCNC1,GRIN2B
1.421e-03	-6.56	regulation of potassium ion transmembrane transport	biological process	GO:1901379	86	3	18204	47	KCNC1,DPP10,KCNIP2
1.438e-03	-6.54	animal organ development	biological process	GO:0048513	2846	16	18204	47	CSMD1,GRIN1,CACNA1H,GRIN2B,CACNA1G,ALK,FGF12,CNTN5,OLFM1,PDE2A,GABRB2,KCNC1,GRID2,NRG3,NTRK3,HCN1
1.453e-03	-6.53	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	22	16828	48	STXBP5,CACNA1H,GRM7,CSMD2,CACNA1A,RIMS2,GRIK2,GRID2,NTRK3,DLG4,KCNT1,KCTD16,GRIA3,GABRB2,ALK,TENM1,HCN1,CADPS,DPP10,NRXN2,MCTP1,GABBR2
1.456e-03	-6.53	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	11	16828	48	HCN1,CNTN5,ALK,PDE2A,KCNC1,CSMD2,KCTD16,KCNT1,GRIN1,GRIK2,NTRK3
1.458e-03	-6.53	postsynapse assembly	biological process	GO:0099068	22	2	18204	47	NRXN1,NRXN2
1.478e-03	-6.52	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	4	18094	48	GRIA3,GRIN2B,GRIK2,GRIN1
1.507e-03	-6.50	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	4	18094	48	GRIN1,GRIA3,GRIN2B,GRIK2
1.520e-03	-6.49	GLS2 (glutaminase 2)	protein interactions	27165	23	2	19454	49	DLG3,DLG4
1.536e-03	-6.48	PDZ domain binding	molecular function	GO:0030165	86	3	18094	48	DLG4,GRIK2,GRID2
1.559e-03	-6.46	G_PROTEIN_RECEP_F3_4	prosite domains	PS50259	20	2	12186	36	GRM7,GABBR2
1.561e-03	-6.46	MAP1A (microtubule associated protein 1A)	protein interactions	4130	91	3	19454	49	DLG4,GRIN2B,KCNMA1
1.567e-03	-6.46	GPCRs, Class C Metabotropic glutamate, pheromone	WikiPathways	WP501	16	2	5310	20	GRM7,GABBR2
1.568e-03	-6.46	multicellular organismal response to stress	biological process	GO:0033555	89	3	18204	47	GRM7,GRIK2,HCN1
1.578e-03	-6.45	Long-term depression	KEGG pathways	hsa04730	60	3	7161	28	GRID2,GRIA3,CACNA1A
1.578e-03	-6.45	Long-term depression	KEGG pathways	ko04730	60	3	7161	28	GRID2,CACNA1A,GRIA3
1.594e-03	-6.44	GPCR_3_C	interpro domains	IPR017978	22	2	18521	50	GABBR2,GRM7
1.594e-03	-6.44	Guanylate_kin-like_dom	interpro domains	IPR008144	22	2	18521	50	DLG4,DLG3
1.595e-03	-6.44	inhibitory synapse assembly	biological process	GO:1904862	23	2	18204	47	GABRA1,GABRB2
1.603e-03	-6.44	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	41	16828	48	GABRD,CELF5,CNTN5,FGF12,KCNMA1,GPR85,CACNA1G,CHRM2,NRXN1,NRXN2,GABBR2,SYT7,DLG3,DPP10,RIMS2,OLFM1,GRIA3,KCTD16,CELF4,GRIK2,RALYL,DLG4,TENM1,HCN1,SCN8A,PDE2A,ALK,KCNC1,MCTP1,NRG3,CADPS,GABRA1,GPHN,CSMD2,CACNA1A,GRIN2B,SYT1,GRM7,KCNT1,NTRK3,GRID2
1.611e-03	-6.43	KDM5B (lysine demethylase 5B)	protein interactions	10765	92	3	19454	49	GRIN2B,CACNA1H,CACNA1A
1.617e-03	-6.43	C2 domain	gene3d domains	2.60.40.150	156	4	14470	47	SYT7,RIMS2,SYT1,MCTP1
1.656e-03	-6.40	CNKSR2 (connector enhancer of kinase suppressor of Ras 2)	protein interactions	22866	24	2	19454	49	DLG3,DLG4
1.656e-03	-6.40	KCNMA1 (potassium calcium-activated channel subfamily M alpha 1)	protein interactions	3778	24	2	19454	49	KCNMA1,CACNA1H
1.656e-03	-6.40	RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1)	protein interactions	5923	24	2	19454	49	NTRK3,GRIN2B
1.657e-03	-6.40	7tm_3	pfam domains	PF00003	22	2	17795	49	GRM7,GABBR2
1.701e-03	-6.38	adenoma	COSMIC cancer mutations	adenoma	2873	17	16828	48	PDE2A,GABRB2,ALK,KCNMA1,HCN1,CNTN5,CADPS,GABBR2,STXBP5,OLFM1,GRM7,CSMD2,RIMS2,SYT1,GRID2,GRIN1,GRIK2
1.715e-03	-6.37	sodium channel complex	cellular component	GO:0034706	24	2	19108	49	SCN8A,GRIK2
1.737e-03	-6.36	postsynaptic density organization	biological process	GO:0097106	24	2	18204	47	NRXN2,NRXN1
1.737e-03	-6.36	positive regulation of dendrite extension	biological process	GO:1903861	24	2	18204	47	SYT1,RIMS2
1.792e-03	-6.32	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	WikiPathways	WP2380	144	4	5310	20	GRIN2B,NTRK3,GRIN1,GRIA3
1.797e-03	-6.32	CRIPT (CXXC repeat containing interactor of PDZ3 domain)	protein interactions	9419	25	2	19454	49	DLG3,DLG4
1.800e-03	-6.32	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	47	16828	48	CACNA1A,CSMD2,GRM7,MCTP1,CADPS,GABRA1,SCN8A,TENM1,ALK,PDE2A,GRIA3,FAM131A,GRIK2,GRIN1,CELF4,RIMS2,GABBR2,NRXN2,NRXN1,KCNMA1,GPR85,CACNA1G,GABRD,KCNT1,NTRK3,GRID2,SYT1,GRIN2B,STXBP5,KCNC1,GPHN,NRG3,HCN1,KCTD16,RALYL,DLG4,CACNA1H,CELF2,KCNIP2,DPP10,SYT7,DLG3,CNTN5,FGF12,CELF5,CHRM2,GABRB2
1.804e-03	-6.32	NRIONCHANNEL	prints domains	PR00252	43	3	5227	30	GABRB2,GABRA1,GABRD
1.818e-03	-6.31	human chr9q34.3	chromosome location	human chr9q34.3	126	3	26134	50	KCNT1,OLFM1,GRIN1
1.832e-03	-6.30	cAMP binding	molecular function	GO:0030552	24	2	18094	48	HCN1,PDE2A
1.833e-03	-6.30	neurogenesis	biological process	GO:0022008	1334	10	18204	47	GRM7,TENM1,GABRB2,KCNIP2,ALK,NRXN1,GRID2,CNTN5,HCN1,DLG4
1.861e-03	-6.29	neuronal dense core vesicle	cellular component	GO:0098992	25	2	19108	49	CADPS,STXBP5
1.865e-03	-6.28	circulatory system process	biological process	GO:0003013	508	6	18204	47	KCNMA1,ASIC2,PDE2A,FGF12,CACNA1G,SCN8A
1.868e-03	-6.28	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	10	16828	48	DPP10,GRID2,NRG3,GRM7,CACNA1H,GABRB2,GRIN2B,RIMS2,SYT1,CACNA1A
1.885e-03	-6.27	regulation of long-term neuronal synaptic plasticity	biological process	GO:0048169	25	2	18204	47	GRIK2,DLG4
1.889e-03	-6.27	GUANYLATE_KINASE_2	prosite domains	PS50052	22	2	12186	36	DLG3,DLG4
1.913e-03	-6.26	human chr17q11.2-q12	chromosome location	human chr17q11.2-q12	1	1	26134	50	ASIC2
1.913e-03	-6.26	human chr2p23.2-p23.1	chromosome location	human chr2p23.2-p23.1	1	1	26134	50	ALK
1.913e-03	-6.26	human chr3q28-q29	chromosome location	human chr3q28-q29	1	1	26134	50	FGF12
1.913e-03	-6.26	human chr4q22.1-q22.2	chromosome location	human chr4q22.1-q22.2	1	1	26134	50	GRID2
1.943e-03	-6.24	TSPAN7 (tetraspanin 7)	protein interactions	7102	26	2	19454	49	CACNA1A,CHRM2
1.943e-03	-6.24	DLGAP2 (DLG associated protein 2)	protein interactions	9228	26	2	19454	49	DLG3,DLG4
1.949e-03	-6.24	endocytic vesicle	cellular component	GO:0030139	349	5	19108	49	SYT7,DLG4,CHRM2,SYT1,GRIA3
2.007e-03	-6.21	nerve development	biological process	GO:0021675	97	3	18204	47	GABRB2,KCNC1,SCN8A
2.034e-03	-6.20	macromolecule localization	biological process	GO:0033036	2376	14	18204	47	NRXN1,GRID2,HCN1,NRXN2,STXBP5,RIMS2,DLG3,GPHN,GRIK2,CADPS,DLG4,DPP10,ASIC2,SYT7
2.039e-03	-6.20	Nitric oxide stimulates guanylate cyclase	REACTOME pathways	R-HSA-392154	24	2	10285	29	KCNMA1,PDE2A
2.059e-03	-6.19	GK/Ca_channel_bsu	interpro domains	IPR008145	25	2	18521	50	DLG4,DLG3
2.082e-03	-6.17	cellular localization	biological process	GO:0051641	2660	15	18204	47	CADPS,DLG4,ASIC2,DPP10,SYT7,GRID2,NRXN1,SYT1,NRXN2,HCN1,DLG3,RIMS2,STXBP5,GPHN,GRIK2
2.095e-03	-6.17	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	49	DLG3,DLG4
2.095e-03	-6.17	DLGAP3 (DLG associated protein 3)	protein interactions	58512	27	2	19454	49	DLG3,DLG4
2.095e-03	-6.17	DLGAP1 (DLG associated protein 1)	protein interactions	9229	27	2	19454	49	DLG3,DLG4
2.104e-03	-6.16	PRKCG (protein kinase C gamma)	protein interactions	5582	101	3	19454	49	GRIN1,GRIN2B,GABRA1
2.106e-03	-6.16	monoatomic anion channel activity	molecular function	GO:0005253	96	3	18094	48	GABRB2,GABRA1,GABRD
2.127e-03	-6.15	heart contraction	biological process	GO:0060047	99	3	18204	47	FGF12,CACNA1G,SCN8A
2.140e-03	-6.15	Guanylate_kin	pfam domains	PF00625	25	2	17795	49	DLG4,DLG3
2.141e-03	-6.15	lung-carcinoid-endocrine_tumour-typical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-typical	321	5	16828	48	TENM1,DPP10,ALK,NTRK3,DLG3
2.141e-03	-6.15	typical	COSMIC cancer mutations	typical	321	5	16828	48	DPP10,ALK,NTRK3,DLG3,TENM1
2.150e-03	-6.14	ionotropic glutamate receptor binding	molecular function	GO:0035255	26	2	18094	48	DLG4,DLG3
2.155e-03	-6.14	positive regulation of monoatomic ion transport	biological process	GO:0043270	212	4	18204	47	KCNC1,KCNIP2,GRIN1,FGF12
2.158e-03	-6.14	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	31	16828	48	OLFM1,CACNA1H,GRIN1,CELF4,RALYL,KCTD16,GRIA3,GABRB2,CHRM2,CELF5,FGF12,SYT7,DPP10,NRXN2,GABBR2,GRM7,CSMD2,CACNA1A,SYT1,GRIN2B,NTRK3,GRID2,KCNT1,PDE2A,ALK,TENM1,HCN1,SCN8A,GABRA1,NRG3,MCTP1
2.170e-03	-6.13	RRM_1	pfam domains	PF00076	199	4	17795	49	CELF4,CELF5,RALYL,CELF2
2.170e-03	-6.13	dendrite cytoplasm	cellular component	GO:0032839	27	2	19108	49	GRIK2,DLG4
2.171e-03	-6.13	bladder	COSMIC cancer mutations	bladder	14112	47	16828	48	NRXN1,NRXN2,GABBR2,GABRD,KCNMA1,GPR85,CACNA1G,CELF4,GRIK2,GRIN1,FAM131A,GRIA3,RIMS2,GABRA1,CADPS,MCTP1,PDE2A,ALK,TENM1,SCN8A,GRM7,CSMD2,CACNA1A,SYT7,DLG3,DPP10,KCNIP2,GABRB2,CHRM2,CELF5,CNTN5,FGF12,RALYL,DLG4,KCTD16,CELF2,CACNA1H,NRG3,GPHN,KCNC1,HCN1,NTRK3,GRID2,KCNT1,STXBP5,SYT1,GRIN2B
2.171e-03	-6.13	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	47	16828	48	GRM7,CSMD2,CACNA1A,CADPS,GABRA1,MCTP1,PDE2A,ALK,TENM1,SCN8A,GRIK2,CELF4,GRIN1,FAM131A,GRIA3,RIMS2,NRXN2,NRXN1,GABBR2,GABRD,KCNMA1,GPR85,CACNA1G,GRID2,NTRK3,KCNT1,STXBP5,GRIN2B,SYT1,NRG3,GPHN,KCNC1,HCN1,DLG4,RALYL,KCTD16,CACNA1H,CELF2,SYT7,DLG3,DPP10,KCNIP2,GABRB2,CHRM2,CELF5,FGF12,CNTN5
2.198e-03	-6.12	positive regulation of protein tyrosine kinase activity	biological process	GO:0061098	27	2	18204	47	DLG3,DLG4
2.198e-03	-6.12	regulation of dendrite extension	biological process	GO:1903859	27	2	18204	47	RIMS2,SYT1
2.198e-03	-6.12	postsynaptic specialization organization	biological process	GO:0099084	27	2	18204	47	NRXN1,NRXN2
2.219e-03	-6.11	cellular component organization or biogenesis	biological process	GO:0071840	5850	25	18204	47	ASIC2,CELF2,TENM1,GRIN2B,CNTN5,GABRB2,GABRA1,KCNIP2,GRID2,KCNC1,GRM7,CELF4,GRIN1,SYT7,DLG4,KCNMA1,KCTD16,GPHN,OLFM1,CELF5,NRG3,NRXN1,SYT1,NRXN2,HCN1
2.232e-03	-6.10	thyroid	COSMIC cancer mutations	thyroid	9867	38	16828	48	RIMS2,CACNA1H,CELF2,OLFM1,GRIA3,CELF4,GRIN1,GRIK2,RALYL,DLG4,CELF5,GABRD,CACNA1G,KCNMA1,CNTN5,NRXN2,NRXN1,GABBR2,KCNIP2,DLG3,SYT7,DPP10,CSMD2,GRIN2B,SYT1,CACNA1A,KCNT1,NTRK3,GRID2,TENM1,SCN8A,HCN1,PDE2A,ALK,KCNC1,CADPS,GABRA1,NRG3
2.252e-03	-6.10	actin filament-based movement	biological process	GO:0030048	101	3	18204	47	SCN8A,CACNA1G,FGF12
2.252e-03	-6.10	regulation of potassium ion transport	biological process	GO:0043266	101	3	18204	47	DPP10,KCNIP2,KCNC1
2.264e-03	-6.09	Amphetamine addiction	KEGG pathways	ko05031	68	3	7161	28	GRIN1,GRIN2B,GRIA3
2.264e-03	-6.09	Amphetamine addiction	KEGG pathways	hsa05031	68	3	7161	28	GRIN2B,GRIA3,GRIN1
2.319e-03	-6.07	outward rectifier potassium channel activity	molecular function	GO:0015271	27	2	18094	48	KCNT1,KCNIP2
2.363e-03	-6.05	regulation of calcium ion-dependent exocytosis	biological process	GO:0017158	28	2	18204	47	SYT1,SYT7
2.363e-03	-6.05	startle response	biological process	GO:0001964	28	2	18204	47	CSMD1,GRID2
2.392e-03	-6.04	pharynx	COSMIC cancer mutations	pharynx	2696	16	16828	48	DPP10,NRG3,KCNIP2,NRXN2,ALK,CHRM2,HCN1,SCN8A,GPR85,GABRD,TENM1,CACNA1H,STXBP5,CACNA1A,GRIN2B,CSMD2
2.392e-03	-6.04	Ligand-gated ion channel transport	REACTOME pathways	R-HSA-975298	26	2	10285	29	GABRB2,GABRA1
2.393e-03	-6.04	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	22	16828	48	RIMS2,OLFM1,CACNA1H,GRIA3,KCTD16,CNTN5,CACNA1G,NRXN2,GABBR2,DPP10,CSMD2,CACNA1A,STXBP5,KCNT1,NTRK3,GRID2,TENM1,HCN1,ALK,KCNC1,CADPS,NRG3
2.393e-03	-6.04	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	22	16828	48	GABBR2,NRXN2,DPP10,CACNA1G,CNTN5,KCTD16,GRIA3,RIMS2,CACNA1H,OLFM1,KCNC1,CADPS,NRG3,HCN1,TENM1,ALK,KCNT1,NTRK3,GRID2,CACNA1A,CSMD2,STXBP5
2.403e-03	-6.03	brain development	biological process	GO:0007420	724	7	18204	47	GRIN1,ALK,NRG3,GRID2,KCNC1,GRIN2B,CNTN5
2.447e-03	-6.01	inorganic cation import across plasma membrane	biological process	GO:0098659	104	3	18204	47	CACNA1A,CACNA1G,CACNA1H
2.447e-03	-6.01	inorganic ion import across plasma membrane	biological process	GO:0099587	104	3	18204	47	CACNA1G,CACNA1A,CACNA1H
2.519e-03	-5.98	Apob (apolipoprotein B)	protein interactions	54225	1	1	19454	49	CELF2
2.519e-03	-5.98	KCNC2 (potassium voltage-gated channel subfamily C member 2)	protein interactions	3747	1	1	19454	49	KCNC1
2.519e-03	-5.98	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	49	NRXN1
2.519e-03	-5.98	Kcna4 (potassium voltage-gated channel subfamily A member 4)	protein interactions	25469	1	1	19454	49	DLG4
2.519e-03	-5.98	Shank1 (SH3 and multiple ankyrin repeat domains 1)	protein interactions	78957	1	1	19454	49	DLG4
2.519e-03	-5.98	Cript (CXXC repeat containing interactor of PDZ3 domain)	protein interactions	56725	1	1	19454	49	DLG4
2.519e-03	-5.98	Setsip (SET like protein)	protein interactions	307947	1	1	19454	49	CHRM2
2.519e-03	-5.98	Rnf138 (ring finger protein 138)	protein interactions	94196	1	1	19454	49	CACNA1A
2.519e-03	-5.98	Pick1 (protein interacting with C kinase 1)	protein interactions	18693	1	1	19454	49	ASIC2
2.543e-03	-5.97	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	19	16828	48	CNTN5,HCN1,SCN8A,CACNA1G,ALK,GABBR2,DPP10,NRG3,CACNA1A,RIMS2,CSMD2,GRM7,OLFM1,CELF2,STXBP5,KCNT1,DLG4,NTRK3,GRID2
2.556e-03	-5.97	EGF_3	prosite domains	PS50026	196	4	12186	36	NRG3,TENM1,NRXN1,NRXN2
2.561e-03	-5.97	middle_third	COSMIC cancer mutations	middle_third	3533	19	16828	48	CNTN5,HCN1,CACNA1G,SCN8A,ALK,GABBR2,DPP10,NRG3,CACNA1A,RIMS2,CSMD2,GRM7,CELF2,OLFM1,STXBP5,KCNT1,DLG4,NTRK3,GRID2
2.563e-03	-5.97	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	8	16828	48	GRID2,CADPS,KCTD16,GRIA3,GRM7,GABRB2,RIMS2,GABRD
2.564e-03	-5.97	extrinsic component of dense core granule membrane	cellular component	GO:0098922	1	1	19108	49	STXBP5
2.564e-03	-5.97	mossy fiber rosette	cellular component	GO:0097471	1	1	19108	49	GRIK2
2.564e-03	-5.97	extrinsic component of neuronal dense core vesicle membrane	cellular component	GO:0098674	1	1	19108	49	STXBP5
2.582e-03	-5.96	sensory perception of cold stimulus	biological process	GO:0062035	1	1	18204	47	GRIK2
2.582e-03	-5.96	positive regulation of calcium ion-dependent exocytosis of neurotransmitter	biological process	GO:1903235	1	1	18204	47	SYT1
2.582e-03	-5.96	regulation of retina development in camera-type eye	biological process	GO:1902866	1	1	18204	47	CELF4
2.582e-03	-5.96	regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback	biological process	GO:0003026	1	1	18204	47	ASIC2
2.582e-03	-5.96	response to environmental enrichment	biological process	GO:0090648	1	1	18204	47	ALK
2.582e-03	-5.96	synchronous neurotransmitter secretion	biological process	GO:0071911	1	1	18204	47	SYT1
2.582e-03	-5.96	propylene metabolic process	biological process	GO:0018964	1	1	18204	47	GRIN1
2.582e-03	-5.96	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	47	NRG3
2.582e-03	-5.96	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	47	NRG3
2.582e-03	-5.96	detection of cold stimulus involved in thermoception	biological process	GO:0120169	1	1	18204	47	GRIK2
2.582e-03	-5.96	glycine receptor clustering	biological process	GO:0072579	1	1	18204	47	GPHN
2.582e-03	-5.96	fast, calcium ion-dependent exocytosis of neurotransmitter	biological process	GO:0098746	1	1	18204	47	SYT1
2.584e-03	-5.96	GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B)	protein interactions	116444	30	2	19454	49	GRIN1,DLG4
2.653e-03	-5.93	P2Y1 nucleotide receptor binding	molecular function	GO:0031812	1	1	18094	48	DLG4
2.653e-03	-5.93	molybdopterin molybdotransferase activity	molecular function	GO:0061599	1	1	18094	48	GPHN
2.653e-03	-5.93	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0140232	1	1	18094	48	HCN1
2.653e-03	-5.93	molybdopterin adenylyltransferase activity	molecular function	GO:0061598	1	1	18094	48	GPHN
2.653e-03	-5.93	G protein-coupled nucleotide receptor binding	molecular function	GO:0031811	1	1	18094	48	DLG4
2.673e-03	-5.92	ligand-gated calcium channel activity	molecular function	GO:0099604	29	2	18094	48	GRIN1,GRIN2B
2.678e-03	-5.92	RRM_dom	interpro domains	IPR000504	215	4	18521	50	CELF4,CELF5,CELF2,RALYL
2.700e-03	-5.91	C2A_Synaptotagmin-7	interpro domains	IPR037732	1	1	18521	50	SYT7
2.700e-03	-5.91	GABRA1_ECD	interpro domains	IPR047079	1	1	18521	50	GABRA1
2.700e-03	-5.91	MoCF_biosynth_CS	interpro domains	IPR008284	1	1	18521	50	GPHN
2.700e-03	-5.91	GBR2_CC	interpro domains	IPR041689	1	1	18521	50	GABBR2
2.700e-03	-5.91	C2B_Synaptotagmin-7	interpro domains	IPR037741	1	1	18521	50	SYT7
2.700e-03	-5.91	GPCR_3_mGluR7	interpro domains	IPR001883	1	1	18521	50	GRM7
2.700e-03	-5.91	MoeA_linker/N_sf	interpro domains	IPR036135	1	1	18521	50	GPHN
2.700e-03	-5.91	MoeA_C_domain_IV_sf	interpro domains	IPR036688	1	1	18521	50	GPHN
2.700e-03	-5.91	DLG3_SH3	interpro domains	IPR035763	1	1	18521	50	DLG3
2.700e-03	-5.91	GABBAa1_rcpt	interpro domains	IPR005431	1	1	18521	50	GABRA1
2.700e-03	-5.91	CACNA1A	interpro domains	IPR005448	1	1	18521	50	CACNA1A
2.700e-03	-5.91	GPCR_3_GABA_rcpt_B2	interpro domains	IPR002457	1	1	18521	50	GABBR2
2.700e-03	-5.91	MoeA-like	interpro domains	IPR038987	1	1	18521	50	GPHN
2.700e-03	-5.91	Na_channel_a8su	interpro domains	IPR008054	1	1	18521	50	SCN8A
2.700e-03	-5.91	MoeA_linker/N	interpro domains	IPR005110	1	1	18521	50	GPHN
2.700e-03	-5.91	K_chnl_volt-dep_Kv3	interpro domains	IPR005403	1	1	18521	50	KCNC1
2.700e-03	-5.91	MoeA_C_domain_IV	interpro domains	IPR005111	1	1	18521	50	GPHN
2.700e-03	-5.91	Musac_Ach_M2_rcpt	interpro domains	IPR001065	1	1	18521	50	CHRM2
2.700e-03	-5.91	NTRK3	interpro domains	IPR020446	1	1	18521	50	NTRK3
2.700e-03	-5.91	GABAAd_rcpt	interpro domains	IPR008098	1	1	18521	50	GABRD
2.751e-03	-5.90	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	47	16828	48	HCN1,NRG3,KCNC1,STXBP5,GRIN2B,SYT1,NTRK3,GRID2,KCNT1,GABRB2,CHRM2,CELF5,FGF12,CNTN5,SYT7,DLG3,DPP10,KCNIP2,CELF2,CACNA1H,RALYL,DLG4,KCTD16,PDE2A,ALK,TENM1,SCN8A,GABRA1,CADPS,MCTP1,GRM7,CSMD2,CACNA1A,GABRD,KCNMA1,GPR85,CACNA1G,NRXN1,NRXN2,GABBR2,OLFM1,RIMS2,CELF4,GRIN1,GRIK2,FAM131A,GRIA3
2.754e-03	-5.89	MoeA_C	pfam domains	PF03454	1	1	17795	49	GPHN
2.754e-03	-5.89	GBR2_CC	pfam domains	PF18455	1	1	17795	49	GABBR2
2.754e-03	-5.89	MoeA_N	pfam domains	PF03453	1	1	17795	49	GPHN
2.758e-03	-5.89	HECTD4 (HECT domain E3 ubiquitin protein ligase 4)	protein interactions	283450	31	2	19454	49	GRIA3,GRIN2B
2.777e-03	-5.89	GPCRMGR	prints domains	PR00248	14	2	5227	30	GRM7,GABBR2
2.790e-03	-5.88	L1CAM interactions	REACTOME pathways	R-HSA-373760	101	3	10285	29	DLG3,SCN8A,DLG4
2.869e-03	-5.85	chloride transmembrane transport	biological process	GO:1902476	110	3	18204	47	GABRD,GABRB2,GABRA1
2.869e-03	-5.85	positive regulation of cell junction assembly	biological process	GO:1901890	110	3	18204	47	ASIC2,NRXN1,GRID2
2.916e-03	-5.84	positive regulation of transferase activity	biological process	GO:0051347	381	5	18204	47	NTRK3,DLG3,ALK,TENM1,DLG4
2.944e-03	-5.83	regulation of mRNA splicing, via spliceosome	biological process	GO:0048024	111	3	18204	47	CELF2,CELF4,CELF5
2.954e-03	-5.82	MOCF_BIOSYNTHESIS_1	prosite domains	PS01078	1	1	12186	36	GPHN
2.954e-03	-5.82	MOCF_BIOSYNTHESIS_2	prosite domains	PS01079	1	1	12186	36	GPHN
3.024e-03	-5.80	nodular	COSMIC cancer mutations	nodular	1515	11	16828	48	KCNT1,GRID2,NTRK3,GRIK2,GRIN2B,CSMD2,GRM7,GABBR2,GABRA1,HCN1,CELF5
3.028e-03	-5.80	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	10	16828	48	CACNA1H,ALK,CACNA1A,CNTN5,CACNA1G,RIMS2,CADPS,DPP10,KCNT1,KCTD16
3.042e-03	-5.80	CDH2 (cadherin 2)	protein interactions	1000	115	3	19454	49	NTRK3,GRIN1,GRIK2
3.042e-03	-5.80	presynaptic active zone membrane	cellular component	GO:0048787	32	2	19108	49	HCN1,SCN8A
3.096e-03	-5.78	heart process	biological process	GO:0003015	113	3	18204	47	SCN8A,CACNA1G,FGF12
3.175e-03	-5.75	upper_leg	COSMIC cancer mutations	upper_leg	880	8	16828	48	CADPS,GRID2,KCTD16,GRIA3,GRM7,GABRB2,RIMS2,GABRD
3.180e-03	-5.75	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	32	16828	48	KCNT1,NTRK3,GRID2,CACNA1A,SYT1,GRIN2B,CSMD2,GRM7,MCTP1,NRG3,GABRA1,HCN1,SCN8A,TENM1,ALK,PDE2A,KCTD16,GRIA3,RALYL,GRIN1,CELF4,OLFM1,CACNA1H,GABBR2,NRXN2,DPP10,SYT7,DLG3,FGF12,CELF5,CHRM2,GABRB2
3.222e-03	-5.74	RRM	prosite domains	PS50102	209	4	12186	36	RALYL,CELF2,CELF4,CELF5
3.248e-03	-5.73	Molybdopterin biosynthesis moea protein, domain 2	gene3d domains	3.90.105.10	1	1	14470	47	GPHN
3.248e-03	-5.73	MoeA, C-terminal, domain IV	gene3d domains	2.40.340.10	1	1	14470	47	GPHN
3.248e-03	-5.73	Molybdopterin biosynthesis moea protein, domain 3	gene3d domains	2.170.190.11	1	1	14470	47	GPHN
3.249e-03	-5.73	protein tyrosine kinase activator activity	molecular function	GO:0030296	32	2	18094	48	ALK,NRG3
3.294e-03	-5.72	breast-other-papilloma	COSMIC cancer mutations	breast-other-papilloma	30	2	16828	48	NTRK3,ALK
3.294e-03	-5.72	adenosis	COSMIC cancer mutations	adenosis	30	2	16828	48	ALK,NTRK3
3.294e-03	-5.72	breast-other-adenosis	COSMIC cancer mutations	breast-other-adenosis	30	2	16828	48	NTRK3,ALK
3.312e-03	-5.71	SEMA4F (ssemaphorin 4F)	protein interactions	10505	34	2	19454	49	GRIA3,DLG4
3.330e-03	-5.70	regulation of metal ion transport	biological process	GO:0010959	393	5	18204	47	FGF12,GRIN1,DPP10,KCNIP2,KCNC1
3.415e-03	-5.68	regulation of synapse assembly	biological process	GO:0051963	117	3	18204	47	GRID2,NRXN1,ASIC2
3.430e-03	-5.68	ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15)	protein interactions	158866	120	3	19454	49	RIMS2,MCTP1,NRXN1
3.487e-03	-5.66	head development	biological process	GO:0060322	774	7	18204	47	GRID2,NRG3,GRIN2B,KCNC1,ALK,CNTN5,GRIN1
3.507e-03	-5.65	NRXN1 (neurexin 1)	protein interactions	9378	35	2	19454	49	SYT1,SYT7
3.507e-03	-5.65	GRIK1 (glutamate ionotropic receptor kainate type subunit 1)	protein interactions	2897	35	2	19454	49	DLG4,GRIK2
3.519e-03	-5.65	EGF-like_dom	interpro domains	IPR000742	232	4	18521	50	NRG3,TENM1,NRXN2,NRXN1
3.567e-03	-5.64	bone	COSMIC cancer mutations	bone	8157	33	16828	48	CSMD2,CACNA1A,GRIN2B,SYT1,STXBP5,GRM7,KCNT1,NTRK3,GRID2,TENM1,HCN1,SCN8A,ALK,KCNC1,NRG3,CADPS,CELF2,OLFM1,CACNA1H,GRIA3,GRIK2,GRIN1,CELF4,FAM131A,DLG4,GABRD,CNTN5,FGF12,CACNA1G,GABRB2,NRXN1,NRXN2,GABBR2
3.607e-03	-5.62	cellular response to nitrogen compound	biological process	GO:1901699	580	6	18204	47	CACNA1A,PDE2A,CHRM2,GABRB2,GRIN1,HCN1
3.613e-03	-5.62	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME pathways	R-HSA-399721	32	2	10285	29	GRIA3,DLG4
3.613e-03	-5.62	Trafficking of AMPA receptors	REACTOME pathways	R-HSA-399719	32	2	10285	29	GRIA3,DLG4
3.638e-03	-5.62	central nervous system development	biological process	GO:0007417	995	8	18204	47	ASIC2,GRIN1,ALK,KCNC1,GRIN2B,GRID2,NRG3,CNTN5
3.667e-03	-5.61	striated muscle contraction	biological process	GO:0006941	120	3	18204	47	FGF12,CACNA1G,SCN8A
3.677e-03	-5.61	behavioral fear response	biological process	GO:0001662	35	2	18204	47	GRM7,GRIK2
3.677e-03	-5.61	presynaptic modulation of chemical synaptic transmission	biological process	GO:0099171	35	2	18204	47	CHRM2,GRIK2
3.681e-03	-5.60	regulation of synapse organization	biological process	GO:0050807	246	4	18204	47	ASIC2,NRXN1,GRIN2B,GRID2
3.714e-03	-5.60	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	48	GRID2,NTRK3,GRIK2,GABRA1,SYT1,GPR85,CSMD2,GABRD,CHRM2
3.754e-03	-5.59	chloride transport	biological process	GO:0006821	121	3	18204	47	GABRA1,GABRB2,GABRD
3.795e-03	-5.57	GuKc	smart domains	SM00072	25	2	9717	36	DLG4,DLG3
3.823e-03	-5.57	human chr8p23.2	chromosome location	human chr8p23.2	2	1	26134	50	CSMD1
3.823e-03	-5.57	human chr14q23.3-q24.1	chromosome location	human chr14q23.3-q24.1	2	1	26134	50	GPHN
3.857e-03	-5.56	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	3	7161	28	PDE2A,CACNA1G,CACNA1H
3.857e-03	-5.56	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	3	7161	28	CACNA1G,CACNA1H,PDE2A
3.867e-03	-5.56	chloride transmembrane transporter activity	molecular function	GO:0015108	119	3	18094	48	GABRD,GABRB2,GABRA1
3.872e-03	-5.55	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	9	16828	48	HCN1,FGF12,CNTN5,GRM7,ALK,KCNT1,NRG3,CELF4,GRID2
3.887e-03	-5.55	behavioral defense response	biological process	GO:0002209	36	2	18204	47	GRIK2,GRM7
3.913e-03	-5.54	GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D)	protein interactions	2906	37	2	19454	49	GRIN1,DLG4
3.931e-03	-5.54	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	6	16828	48	NRG3,GRID2,GRM7,FGF12,HCN1,SYT1
4.010e-03	-5.52	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	4	19454	49	ALK,NTRK3,GRIN1,GRIN2B
4.010e-03	-5.52	regulation of synapse structure or activity	biological process	GO:0050803	252	4	18204	47	GRIN2B,NRXN1,GRID2,ASIC2
4.068e-03	-5.50	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	4	16828	48	OLFM1,CSMD2,RIMS2,HCN1
4.089e-03	-5.50	RBD_domain_sf	interpro domains	IPR035979	242	4	18521	50	RALYL,CELF2,CELF4,CELF5
4.102e-03	-5.50	positive regulation of potassium ion transmembrane transport	biological process	GO:1901381	37	2	18204	47	KCNIP2,KCNC1
4.106e-03	-5.50	SYNAPTOTAGMN	prints domains	PR00399	17	2	5227	30	SYT1,SYT7
4.123e-03	-5.49	GABBR1 (gamma-aminobutyric acid type B receptor subunit 1)	protein interactions	2550	38	2	19454	49	KCTD16,GABBR2
4.241e-03	-5.46	positive regulation of protein kinase activity	biological process	GO:0045860	256	4	18204	47	DLG4,TENM1,NTRK3,DLG3
4.272e-03	-5.46	Nucleotide-bd_a/b_plait_sf	interpro domains	IPR012677	245	4	18521	50	RALYL,CELF2,CELF5,CELF4
4.339e-03	-5.44	GLRB (glycine receptor beta)	protein interactions	2743	39	2	19454	49	GPHN,GRIA3
4.408e-03	-5.42	Laminin_G_2	pfam domains	PF02210	36	2	17795	49	NRXN1,NRXN2
4.435e-03	-5.42	molybdenum cofactor biosynthesis	BIOCYC pathways	HUMAN_PWY-6823	4	1	902	1	GPHN
4.435e-03	-5.42	molybdenum cofactor biosynthesis	BIOCYC pathways	META_PWY-6823	4	1	902	1	GPHN
4.464e-03	-5.41	papilloma	COSMIC cancer mutations	papilloma	35	2	16828	48	NTRK3,ALK
4.464e-03	-5.41	columnar_cell_lesion	COSMIC cancer mutations	columnar_cell_lesion	35	2	16828	48	NTRK3,ALK
4.464e-03	-5.41	ductal_epithelial_hyperplasia-hyperplasia_of_usual_type	COSMIC cancer mutations	ductal_epithelial_hyperplasia-hyperplasia_of_usual_type	35	2	16828	48	NTRK3,ALK
4.464e-03	-5.41	breast-hyperplasia-columnar_cell_lesion	COSMIC cancer mutations	breast-hyperplasia-columnar_cell_lesion	35	2	16828	48	ALK,NTRK3
4.464e-03	-5.41	breast-hyperplasia-ductal_epithelial_hyperplasia-hyperplasia_of_usual_type	COSMIC cancer mutations	breast-hyperplasia-ductal_epithelial_hyperplasia-hyperplasia_of_usual_type	35	2	16828	48	NTRK3,ALK
4.519e-03	-5.40	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	11	16828	48	KCTD16,KCNT1,NRXN1,GRIK2,SYT1,GPR85,RIMS2,CSMD2,ALK,CHRM2,OLFM1
4.547e-03	-5.39	amide binding	molecular function	GO:0033218	254	4	18094	48	GRIN2B,GRIA3,CACNA1A,GRIN1
4.558e-03	-5.39	cyclic nucleotide binding	molecular function	GO:0030551	38	2	18094	48	HCN1,PDE2A
4.590e-03	-5.38	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	10	16828	48	CSMD2,HCN1,CNTN5,PDE2A,KCNC1,KCNT1,KCTD16,NTRK3,GRIN1,GRIK2
4.604e-03	-5.38	PDZ	pfam domains	PF00595	122	3	17795	49	RIMS2,DLG4,DLG3
4.671e-03	-5.37	RAF/MAP kinase cascade	REACTOME pathways	R-HSA-5673001	245	4	10285	29	NRG3,GRIN2B,DLG4,GRIN1
4.671e-03	-5.37	SOS-mediated signalling	REACTOME pathways	R-HSA-112412	245	4	10285	29	GRIN1,NRG3,GRIN2B,DLG4
4.671e-03	-5.37	SHC1 events in EGFR signaling	REACTOME pathways	R-HSA-180336	245	4	10285	29	DLG4,GRIN2B,NRG3,GRIN1
4.671e-03	-5.37	GRB2 events in EGFR signaling	REACTOME pathways	R-HSA-179812	245	4	10285	29	NRG3,GRIN2B,DLG4,GRIN1
4.687e-03	-5.36	response to calcium ion	biological process	GO:0051592	131	3	18204	47	KCNMA1,KCNIP2,SYT1
4.708e-03	-5.36	synaptic vesicle membrane	cellular component	GO:0030672	132	3	19108	49	MCTP1,SYT7,SYT1
4.708e-03	-5.36	exocytic vesicle membrane	cellular component	GO:0099501	132	3	19108	49	SYT1,MCTP1,SYT7
4.718e-03	-5.36	breast-carcinoma_in_situ-lobular_carcinoma_in_situ	COSMIC cancer mutations	breast-carcinoma_in_situ-lobular_carcinoma_in_situ	36	2	16828	48	NTRK3,ALK
4.718e-03	-5.36	lobular_carcinoma_in_situ	COSMIC cancer mutations	lobular_carcinoma_in_situ	36	2	16828	48	ALK,NTRK3
4.722e-03	-5.36	dendrite membrane	cellular component	GO:0032590	40	2	19108	49	KCNC1,GABRA1
4.749e-03	-5.35	LAM_G_DOMAIN	prosite domains	PS50025	35	2	12186	36	NRXN2,NRXN1
4.781e-03	-5.34	fear response	biological process	GO:0042596	40	2	18204	47	GRIK2,GRM7
4.783e-03	-5.34	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	6	16828	48	ALK,SYT7,GRIA3,CACNA1A,CNTN5,CSMD2
4.787e-03	-5.34	WBP1 (WW domain binding protein 1)	protein interactions	23559	41	2	19454	49	CACNA1A,KCNIP2
4.787e-03	-5.34	KCNJ2 (potassium inwardly rectifying channel subfamily J member 2)	protein interactions	3759	41	2	19454	49	DLG3,DLG4
4.788e-03	-5.34	regulation of mRNA processing	biological process	GO:0050684	132	3	18204	47	CELF5,CELF2,CELF4
4.788e-03	-5.34	inorganic anion transmembrane transport	biological process	GO:0098661	132	3	18204	47	GABRA1,GABRD,GABRB2
4.810e-03	-5.34	NCAM1 interactions	REACTOME pathways	R-HSA-419037	37	2	10285	29	CACNA1G,CACNA1H
4.867e-03	-5.33	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	6	16828	48	ALK,CSMD2,CACNA1A,CNTN5,SYT7,GRIA3
4.947e-03	-5.31	Signalling to p38 via RIT and RIN	REACTOME pathways	R-HSA-187706	249	4	10285	29	DLG4,GRIN2B,NRG3,GRIN1
4.947e-03	-5.31	ARMS-mediated activation	REACTOME pathways	R-HSA-170984	249	4	10285	29	GRIN2B,NRG3,DLG4,GRIN1
5.009e-03	-5.30	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	7	16828	48	GRIN2B,RIMS2,CSMD2,CACNA1H,DPP10,GRID2,CADPS
5.018e-03	-5.29	Frs2-mediated activation	REACTOME pathways	R-HSA-170968	250	4	10285	29	DLG4,NRG3,GRIN2B,GRIN1
5.018e-03	-5.29	KCND3 (potassium voltage-gated channel subfamily D member 3)	protein interactions	3752	42	2	19454	49	DPP10,KCNIP2
5.031e-03	-5.29	C17orf67 (chromosome 17 open reading frame 67)	protein interactions	339210	2	1	19454	49	CADPS
5.031e-03	-5.29	ZNF233 (zinc finger protein 233)	protein interactions	353355	2	1	19454	49	CACNA1A
5.031e-03	-5.29	Dlgap1 (DLG associated protein 1)	protein interactions	65040	2	1	19454	49	DLG4
5.031e-03	-5.29	AOAH (acyloxyacyl hydrolase)	protein interactions	313	2	1	19454	49	DLG3
5.031e-03	-5.29	Grin2b (glutamate ionotropic receptor NMDA type subunit 2B)	protein interactions	24410	2	1	19454	49	DLG4
5.080e-03	-5.28	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	48	NTRK3,DPP10,KCNT1,GABBR2,CELF2,CSMD2,RIMS2,FGF12
5.080e-03	-5.28	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	48	FGF12,RIMS2,CSMD2,CELF2,GABBR2,KCNT1,DPP10,NTRK3
5.089e-03	-5.28	MAPK1/MAPK3 signaling	REACTOME pathways	R-HSA-5684996	251	4	10285	29	DLG4,GRIN2B,NRG3,GRIN1
5.122e-03	-5.27	Kv4.2-KChIP2 channel complex	cellular component	GO:0071193	2	1	19108	49	KCNIP2
5.122e-03	-5.27	G protein-coupled GABA receptor complex	cellular component	GO:1902712	2	1	19108	49	GABBR2
5.157e-03	-5.27	establishment of synaptic specificity at neuromuscular junction	biological process	GO:0007529	2	1	18204	47	GPHN
5.157e-03	-5.27	olefin metabolic process	biological process	GO:1900673	2	1	18204	47	GRIN1
5.157e-03	-5.27	swimming behavior	biological process	GO:0036269	2	1	18204	47	ALK
5.157e-03	-5.27	cellular alkene metabolic process	biological process	GO:0043449	2	1	18204	47	GRIN1
5.157e-03	-5.27	response to nickel cation	biological process	GO:0010045	2	1	18204	47	CACNA1G
5.157e-03	-5.27	response to carbon monoxide	biological process	GO:0034465	2	1	18204	47	KCNMA1
5.161e-03	-5.27	Prolonged ERK activation events	REACTOME pathways	R-HSA-169893	252	4	10285	29	NRG3,GRIN2B,DLG4,GRIN1
5.234e-03	-5.25	Signaling by Leptin	REACTOME pathways	R-HSA-2586552	253	4	10285	29	GRIN1,GRIN2B,NRG3,DLG4
5.260e-03	-5.25	positive regulation of regulated secretory pathway	biological process	GO:1903307	42	2	18204	47	SYT7,SYT1
5.299e-03	-5.24	voltage-gated calcium channel activity involved SA node cell action potential	molecular function	GO:0086059	2	1	18094	48	CACNA1G
5.299e-03	-5.24	syntaxin-3 binding	molecular function	GO:0030348	2	1	18094	48	SYT1
5.299e-03	-5.24	group III metabotropic glutamate receptor activity	molecular function	GO:0001642	2	1	18094	48	GRM7
5.299e-03	-5.24	intracellular sodium-activated potassium channel activity	molecular function	GO:0005228	2	1	18094	48	KCNT1
5.299e-03	-5.24	BRE binding	molecular function	GO:0042835	2	1	18094	48	CELF4
5.299e-03	-5.24	extracellularly glutamate-gated ion channel activity	molecular function	GO:0005234	2	1	18094	48	GRIK2
5.299e-03	-5.24	large conductance calcium-activated potassium channel activity	molecular function	GO:0060072	2	1	18094	48	KCNMA1
5.332e-03	-5.23	Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME pathways	R-HSA-420499	39	2	10285	29	GRM7,GABBR2
5.366e-03	-5.23	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	12	16828	48	PDE2A,GRM7,CSMD2,GRIN2B,KCNMA1,SYT1,HCN1,CNTN5,GRID2,NTRK3,GRIA3,MCTP1
5.378e-03	-5.23	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	15	16828	48	KCNT1,FAM131A,GRID2,GRIK2,RIMS2,GRIN2B,CSMD2,MCTP1,NRXN2,NRXN1,DPP10,NRG3,CNTN5,FGF12,HCN1
5.381e-03	-5.22	Interleukin receptor SHC signaling	REACTOME pathways	R-HSA-912526	255	4	10285	29	GRIN1,GRIN2B,NRG3,DLG4
5.390e-03	-5.22	extremity	COSMIC cancer mutations	extremity	1876	12	16828	48	GRIA3,NTRK3,GRID2,CSMD2,GRIN2B,SYT1,GRM7,MCTP1,CNTN5,HCN1,KCNMA1,PDE2A
5.392e-03	-5.22	CELF1/2_RRM1	interpro domains	IPR034196	2	1	18521	50	CELF2
5.392e-03	-5.22	CELF1/2_RRM2	interpro domains	IPR034198	2	1	18521	50	CELF2
5.392e-03	-5.22	Slowpoke-like_C	interpro domains	IPR048735	2	1	18521	50	KCNMA1
5.392e-03	-5.22	MoaB/Mog-like_dom_sf	interpro domains	IPR036425	2	1	18521	50	GPHN
5.392e-03	-5.22	MCTP_C	interpro domains	IPR013583	2	1	18521	50	MCTP1
5.392e-03	-5.22	RHS_repeat	interpro domains	IPR031325	2	1	18521	50	TENM1
5.392e-03	-5.22	CELF1/2_RRM3	interpro domains	IPR034199	2	1	18521	50	CELF2
5.392e-03	-5.22	CAPS	interpro domains	IPR033227	2	1	18521	50	CADPS
5.392e-03	-5.22	Lgl_C_dom	interpro domains	IPR013905	2	1	18521	50	STXBP5
5.392e-03	-5.22	MoaB/Mog_dom	interpro domains	IPR001453	2	1	18521	50	GPHN
5.418e-03	-5.22	sodium ion transmembrane transport	biological process	GO:0035725	138	3	18204	47	HCN1,ASIC2,SCN8A
5.456e-03	-5.21	Signalling to RAS	REACTOME pathways	R-HSA-167044	256	4	10285	29	GRIN1,DLG4,GRIN2B,NRG3
5.476e-03	-5.21	Laminin_G	interpro domains	IPR001791	41	2	18521	50	NRXN2,NRXN1
5.492e-03	-5.20	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	4	18094	48	GRIN1,GRIN2B,GRIK2,GRIA3
5.500e-03	-5.20	Slowpoke_C	pfam domains	PF21014	2	1	17795	49	KCNMA1
5.500e-03	-5.20	RHS_repeat	pfam domains	PF05593	2	1	17795	49	TENM1
5.500e-03	-5.20	Gly_rich	pfam domains	PF12810	2	1	17795	49	ALK
5.500e-03	-5.20	PRT_C	pfam domains	PF08372	2	1	17795	49	MCTP1
5.500e-03	-5.20	MoCF_biosynth	pfam domains	PF00994	2	1	17795	49	GPHN
5.500e-03	-5.20	Lgl_C	pfam domains	PF08596	2	1	17795	49	STXBP5
5.527e-03	-5.20	positive regulation of cation transmembrane transport	biological process	GO:1904064	139	3	18204	47	KCNC1,KCNIP2,GRIN1
5.545e-03	-5.19	ligand-gated monoatomic anion channel activity	molecular function	GO:0099095	42	2	18094	48	GABRB2,GABRA1
5.608e-03	-5.18	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	4	10285	29	GRIN1,DLG4,NRG3,GRIN2B
5.632e-03	-5.18	Activation of Na-permeable Kainate Receptors	REACTOME pathways	R-HSA-451307	2	1	10285	29	GRIK2
5.699e-03	-5.17	thyroid-other-neoplasm	COSMIC cancer mutations	thyroid-other-neoplasm	7637	31	16828	48	DPP10,SYT7,KCNIP2,GABBR2,NRXN2,CNTN5,CACNA1G,KCNMA1,GABRD,CELF5,DLG4,GRIN1,CELF4,GRIA3,OLFM1,CELF2,CACNA1H,RIMS2,GABRA1,NRG3,CADPS,KCNC1,ALK,PDE2A,SCN8A,TENM1,NTRK3,CACNA1A,SYT1,GRIN2B,CSMD2
5.739e-03	-5.16	MUSCRINICM2R	prints domains	PR00539	1	1	5227	30	CHRM2
5.739e-03	-5.16	NACHANNEL8	prints domains	PR01667	1	1	5227	30	SCN8A
5.739e-03	-5.16	PQVDCCALPHA1	prints domains	PR01632	1	1	5227	30	CACNA1A
5.739e-03	-5.16	MTABOTROPC7R	prints domains	PR01057	1	1	5227	30	GRM7
5.739e-03	-5.16	GABAARALPHA1	prints domains	PR01614	1	1	5227	30	GABRA1
5.739e-03	-5.16	KV31CHANNEL	prints domains	PR01581	1	1	5227	30	KCNC1
5.739e-03	-5.16	NTKRECEPTOR3	prints domains	PR01942	1	1	5227	30	NTRK3
5.739e-03	-5.16	GABAARDELTA	prints domains	PR01722	1	1	5227	30	GABRD
5.739e-03	-5.16	GABAB2RECPTR	prints domains	PR01178	1	1	5227	30	GABBR2
5.760e-03	-5.16	mammary gland morphogenesis	biological process	GO:0060443	44	2	18204	47	CSMD1,NRG3
5.760e-03	-5.16	cellular response to amyloid-beta	biological process	GO:1904646	44	2	18204	47	CACNA1A,GRIN1
5.864e-03	-5.14	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	47	GABRA1,GABRD,GABRB2
5.920e-03	-5.13	Interleukin-2 signaling	REACTOME pathways	R-HSA-451927	262	4	10285	29	GRIN1,DLG4,GRIN2B,NRG3
5.999e-03	-5.12	Signalling to ERKs	REACTOME pathways	R-HSA-187687	263	4	10285	29	DLG4,NRG3,GRIN2B,GRIN1
6.018e-03	-5.11	positive regulation of potassium ion transport	biological process	GO:0043268	45	2	18204	47	KCNC1,KCNIP2
6.087e-03	-5.10	femur	COSMIC cancer mutations	femur	1197	9	16828	48	DLG4,NRG3,GRID2,GABBR2,CACNA1H,FGF12,HCN1,SYT1,GABRD
6.110e-03	-5.10	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	8	16828	48	GRIN2B,SYT1,CACNA1A,GRM7,CACNA1H,GABRB2,GRID2,NRG3
6.111e-03	-5.10	Laminin	gene3d domains	2.10.25.10	226	4	14470	47	NRG3,NRXN2,TENM1,NRXN1
6.117e-03	-5.10	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	10	16828	48	GABRD,TENM1,CSMD2,CACNA1A,GRIN2B,CACNA1H,ALK,NRXN2,KCNIP2,DPP10
6.117e-03	-5.10	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	10	16828	48	NRXN2,KCNIP2,DPP10,GABRD,CSMD2,TENM1,CACNA1A,GRIN2B,CACNA1H,ALK
6.155e-03	-5.09	LRP2 (LDL receptor related protein 2)	protein interactions	4036	148	3	19454	49	DLG3,DLG4,SYT1
6.161e-03	-5.09	FCERI mediated MAPK activation	REACTOME pathways	R-HSA-2871796	265	4	10285	29	GRIN2B,NRG3,DLG4,GRIN1
6.164e-03	-5.09	EPHB-mediated forward signaling	REACTOME pathways	R-HSA-3928662	42	2	10285	29	GRIN1,GRIN2B
6.205e-03	-5.08	terminal bouton	cellular component	GO:0043195	46	2	19108	49	GRIK2,GRIN1
6.324e-03	-5.06	monoatomic anion transmembrane transporter activity	molecular function	GO:0008509	142	3	18094	48	GABRD,GABRA1,GABRB2
6.346e-03	-5.06	RRM	smart domains	SM00360	202	4	9717	36	RALYL,CELF5,CELF2,CELF4
6.387e-03	-5.05	ACTN2 (actinin alpha 2)	protein interactions	88	150	3	19454	49	DLG4,GRIN2B,GRIN1
6.398e-03	-5.05	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	37	16828	48	HCN1,SCN8A,ALK,PDE2A,MCTP1,GPHN,NRG3,CADPS,GABRA1,GRIN2B,SYT1,CSMD2,GRM7,STXBP5,KCNT1,GRID2,NTRK3,CNTN5,FGF12,CACNA1G,GABRD,CELF5,CHRM2,GABBR2,NRXN1,NRXN2,DPP10,DLG3,RIMS2,CELF2,OLFM1,CACNA1H,GRIA3,KCTD16,DLG4,GRIK2,CELF4
6.412e-03	-5.05	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	48	16828	48	KCNIP2,DLG3,SYT7,DPP10,CELF5,FGF12,CNTN5,GABRB2,CHRM2,KCTD16,RALYL,DLG4,CELF2,CACNA1H,KCNC1,NRG3,GPHN,HCN1,KCNT1,NTRK3,GRID2,SYT1,GRIN2B,STXBP5,NRXN1,NRXN2,GABBR2,GABRD,KCNMA1,GPR85,CACNA1G,GRIA3,GRIN1,CELF4,GRIK2,FAM131A,RIMS2,OLFM1,MCTP1,GABRA1,CADPS,TENM1,SCN8A,PDE2A,ALK,CSMD2,CACNA1A,GRM7
6.472e-03	-5.04	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	37	16828	48	RIMS2,CACNA1H,OLFM1,CELF2,KCTD16,GRIA3,GRIK2,CELF4,DLG4,CELF5,GABRD,CACNA1G,FGF12,CNTN5,CHRM2,NRXN2,NRXN1,GABBR2,DLG3,DPP10,CSMD2,GRIN2B,SYT1,STXBP5,GRM7,KCNT1,NTRK3,GRID2,SCN8A,HCN1,PDE2A,ALK,MCTP1,NRG3,CADPS,GABRA1,GPHN
6.486e-03	-5.04	MoaB/Mog-like domain	gene3d domains	3.40.980.10	2	1	14470	47	GPHN
6.492e-03	-5.04	positive regulation of secretion by cell	biological process	GO:1903532	289	4	18204	47	SYT7,SYT1,CADPS,STXBP5
6.560e-03	-5.03	regulation of cellular process	biological process	GO:0050794	11468	38	18204	47	DPP10,GRM7,CELF4,SYT7,GRIN1,ALK,CHRM2,CADPS,FGF12,GABBR2,DLG4,KCNMA1,GPR85,OLFM1,KCTD16,GRIK2,CELF5,NRXN1,NRG3,SYT1,HCN1,NRXN2,ASIC2,CACNA1A,TENM1,CELF2,GRIN2B,CACNA1G,MCTP1,STXBP5,RIMS2,DLG3,PDE2A,NTRK3,KCNIP2,KCNC1,GRIA3,GRID2
6.578e-03	-5.02	RET signaling	REACTOME pathways	R-HSA-8853659	270	4	10285	29	GRIN1,DLG4,NRG3,GRIN2B
6.590e-03	-5.02	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	20	16828	48	CACNA1A,SYT1,GRIN2B,RIMS2,CSMD2,CELF2,GRIA3,RALYL,GRIK2,GRID2,NTRK3,HCN1,KCNMA1,CACNA1G,CELF5,TENM1,ALK,KCNIP2,NRXN1,NRXN2
6.636e-03	-5.02	response to abiotic stimulus	biological process	GO:0009628	1100	8	18204	47	PDE2A,ASIC2,KCNMA1,GRIN1,GRIK2,KCNC1,NRXN1,NRXN2
6.636e-03	-5.02	BDNF-TrkB Signaling	WikiPathways	WP3676	33	2	5310	20	GRIN1,DLG4
6.663e-03	-5.01	Interleukin-3, 5 and GM-CSF signaling	REACTOME pathways	R-HSA-512988	271	4	10285	29	DLG4,NRG3,GRIN2B,GRIN1
6.702e-03	-5.01	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	46	16828	48	GRIN2B,SYT1,STXBP5,KCNT1,GRID2,NTRK3,HCN1,KCNC1,GPHN,NRG3,CACNA1H,CELF2,KCTD16,DLG4,RALYL,FGF12,CNTN5,CELF5,CHRM2,DPP10,DLG3,SYT7,CACNA1A,CSMD2,GRM7,SCN8A,TENM1,ALK,PDE2A,MCTP1,GABRA1,CADPS,RIMS2,OLFM1,GRIA3,FAM131A,CELF4,GRIK2,GRIN1,GPR85,KCNMA1,CACNA1G,GABRD,GABBR2,NRXN2,NRXN1
6.702e-03	-5.01	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	46	16828	48	KCNC1,GPHN,NRG3,HCN1,KCNT1,NTRK3,GRID2,SYT1,GRIN2B,STXBP5,DPP10,DLG3,SYT7,FGF12,CNTN5,CELF5,CHRM2,KCTD16,DLG4,RALYL,CELF2,CACNA1H,MCTP1,GABRA1,CADPS,SCN8A,TENM1,ALK,PDE2A,CACNA1A,CSMD2,GRM7,GABBR2,NRXN1,NRXN2,CACNA1G,GPR85,KCNMA1,GABRD,GRIA3,FAM131A,GRIN1,GRIK2,CELF4,RIMS2,OLFM1
6.815e-03	-4.99	PICK1 (protein interacting with PRKCA 1)	protein interactions	9463	477	5	19454	49	GRIK2,DLG4,GRM7,ASIC2,GRIA3
6.824e-03	-4.99	regulation of membrane depolarization	biological process	GO:0003254	48	2	18204	47	HCN1,CACNA1G
6.904e-03	-4.98	glutamate receptor binding	molecular function	GO:0035254	47	2	18094	48	DLG3,DLG4
7.076e-03	-4.95	-	gene3d domains	2.60.120.200	121	3	14470	47	ALK,NRXN1,NRXN2
7.139e-03	-4.94	positive regulation of biological process	biological process	GO:0048518	6326	25	18204	47	TENM1,ASIC2,GRIN2B,PDE2A,STXBP5,DLG3,RIMS2,KCNC1,GRID2,NTRK3,KCNIP2,CELF4,DPP10,SYT7,GRIN1,CACNA1H,CADPS,ALK,DLG4,FGF12,OLFM1,KCNMA1,GRIK2,NRXN1,SYT1
7.175e-03	-4.94	PDZ	interpro domains	IPR001478	146	3	18521	50	DLG3,RIMS2,DLG4
7.192e-03	-4.93	potassium channel regulator activity	molecular function	GO:0015459	48	2	18094	48	DPP10,KCNIP2
7.240e-03	-4.93	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	29	KCNIP2,FGF12,SCN8A
7.302e-03	-4.92	response to external stimulus	biological process	GO:0009605	1882	11	18204	47	CSMD1,ASIC2,CHRM2,ALK,GRIK2,PDE2A,NRXN2,NRG3,GRID2,NRXN1,KCNC1
7.325e-03	-4.92	APLP1 (amyloid beta precursor like protein 1)	protein interactions	333	51	2	19454	49	GRIN2B,GRIN1
7.333e-03	-4.92	calcium-mediated signaling	biological process	GO:0019722	154	3	18204	47	MCTP1,GRIN1,GRIN2B
7.368e-03	-4.91	DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic)	protein interactions	8813	158	3	19454	49	NTRK3,GABRA1,ALK
7.384e-03	-4.91	cell differentiation	biological process	GO:0030154	3645	17	18204	47	PDE2A,OLFM1,RIMS2,GABRB2,GRID2,NRXN1,KCNIP2,NTRK3,HCN1,SYT1,CELF4,TENM1,GRM7,CACNA1H,ALK,DLG4,CNTN5
7.386e-03	-4.91	cellular response to cAMP	biological process	GO:0071320	50	2	18204	47	HCN1,PDE2A
7.396e-03	-4.91	MoCF_biosynth	smart domains	SM00852	2	1	9717	36	GPHN
7.420e-03	-4.90	CUB	pfam domains	PF00431	47	2	17795	49	CSMD1,CSMD2
7.447e-03	-4.90	cellular developmental process	biological process	GO:0048869	3648	17	18204	47	RIMS2,OLFM1,PDE2A,GABRB2,NTRK3,KCNIP2,NRXN1,GRID2,SYT1,HCN1,GRM7,TENM1,CELF4,CACNA1H,ALK,CNTN5,DLG4
7.453e-03	-4.90	positive regulation of cellular component organization	biological process	GO:0051130	1122	8	18204	47	TENM1,ASIC2,DLG4,SYT1,NRXN1,GRID2,NTRK3,ALK
7.464e-03	-4.90	positive regulation of monoatomic ion transmembrane transport	biological process	GO:0034767	155	3	18204	47	GRIN1,KCNIP2,KCNC1
7.485e-03	-4.89	calcium channel regulator activity	molecular function	GO:0005246	49	2	18094	48	NRXN2,NRXN1
7.538e-03	-4.89	GOLGA6L5P (golgin A6 family like 5, pseudogene)	protein interactions	374650	3	1	19454	49	CACNA1A
7.538e-03	-4.89	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	49	NRXN1
7.538e-03	-4.89	ARSH (arylsulfatase family member H)	protein interactions	347527	3	1	19454	49	GPHN
7.538e-03	-4.89	NAB2 (mRNA-binding protein NAB2)	protein interactions	852755	3	1	19454	49	RALYL
7.538e-03	-4.89	Dlgap2 (DLG associated protein 2)	protein interactions	116681	3	1	19454	49	GRIN2B
7.587e-03	-4.88	PDZ_sf	interpro domains	IPR036034	149	3	18521	50	RIMS2,DLG4,DLG3
7.605e-03	-4.88	ABCA1 (ATP binding cassette subfamily A member 1)	protein interactions	19	52	2	19454	49	DLG3,RIMS2
7.672e-03	-4.87	Phase 0 - rapid depolarisation	REACTOME pathways	R-HSA-5576892	47	2	10285	29	SCN8A,FGF12
7.674e-03	-4.87	G protein-coupled receptor heterodimeric complex	cellular component	GO:0038039	3	1	19108	49	GABBR2
7.674e-03	-4.87	clathrin-sculpted acetylcholine transport vesicle membrane	cellular component	GO:0060201	3	1	19108	49	SYT1
7.674e-03	-4.87	clathrin-sculpted acetylcholine transport vesicle	cellular component	GO:0060200	3	1	19108	49	SYT1
7.675e-03	-4.87	regulation of protein tyrosine kinase activity	biological process	GO:0061097	51	2	18204	47	DLG4,DLG3
7.675e-03	-4.87	neuromuscular process controlling balance	biological process	GO:0050885	51	2	18204	47	DLG4,NRXN1
7.726e-03	-4.86	short-term synaptic potentiation	biological process	GO:1990926	3	1	18204	47	SYT7
7.726e-03	-4.86	cellular response to 2,3,7,8-tetrachlorodibenzodioxine	biological process	GO:1904613	3	1	18204	47	PDE2A
7.726e-03	-4.86	tertiary alcohol biosynthetic process	biological process	GO:1902645	3	1	18204	47	CACNA1H
7.726e-03	-4.86	smooth muscle contraction involved in micturition	biological process	GO:0060083	3	1	18204	47	KCNMA1
7.726e-03	-4.86	response to glycine	biological process	GO:1905429	3	1	18204	47	GRIN1
7.726e-03	-4.86	calcium ion regulated lysosome exocytosis	biological process	GO:1990927	3	1	18204	47	SYT7
7.726e-03	-4.86	cortisol biosynthetic process	biological process	GO:0034651	3	1	18204	47	CACNA1H
7.726e-03	-4.86	aldosterone biosynthetic process	biological process	GO:0032342	3	1	18204	47	CACNA1H
7.726e-03	-4.86	mammary placode formation	biological process	GO:0060596	3	1	18204	47	NRG3
7.726e-03	-4.86	positive regulation of synaptic vesicle exocytosis	biological process	GO:2000302	3	1	18204	47	SYT1
7.731e-03	-4.86	protein-containing complex localization	biological process	GO:0031503	157	3	18204	47	GPHN,DLG3,DLG4
7.747e-03	-4.86	CUB_dom	interpro domains	IPR000859	49	2	18521	50	CSMD2,CSMD1
7.914e-03	-4.84	regulation of cell projection organization	biological process	GO:0031344	683	6	18204	47	DLG4,NTRK3,ALK,GRIN2B,GRID2,TENM1
7.938e-03	-4.84	serine binding	molecular function	GO:0070905	3	1	18094	48	GRM7
7.938e-03	-4.84	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	molecular function	GO:0004118	3	1	18094	48	PDE2A
7.938e-03	-4.84	G protein-coupled GABA receptor activity	molecular function	GO:0004965	3	1	18094	48	GABBR2
7.938e-03	-4.84	voltage-gated calcium channel activity involved in AV node cell action potential	molecular function	GO:0086056	3	1	18094	48	CACNA1G
7.938e-03	-4.84	nitrate reductase activity	molecular function	GO:0008940	3	1	18094	48	GPHN
7.938e-03	-4.84	beta-1 adrenergic receptor binding	molecular function	GO:0031697	3	1	18094	48	DLG4
7.969e-03	-4.83	response to nerve growth factor	biological process	GO:1990089	52	2	18204	47	NTRK3,KCNC1
8.003e-03	-4.83	monoatomic anion transport	biological process	GO:0006820	159	3	18204	47	GABRA1,GABRD,GABRB2
8.024e-03	-4.83	ANK3 (ankyrin 3)	protein interactions	288	163	3	19454	49	KCNC1,FGF12,NTRK3
8.042e-03	-4.82	Developmental Biology	REACTOME pathways	R-HSA-1266738	1075	8	10285	29	GRIN2B,CACNA1H,CACNA1G,DLG3,DLG4,NRG3,SCN8A,GRIN1
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	GPCR3_GABA-B	interpro domains	IPR002455	3	1	18521	50	GABBR2
8.078e-03	-4.82	FAM131	interpro domains	IPR026782	3	1	18521	50	FAM131A
8.078e-03	-4.82	Noelin_dom	interpro domains	IPR022082	3	1	18521	50	OLFM1
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK3
8.078e-03	-4.82	GABAAb_rcpt	interpro domains	IPR002289	3	1	18521	50	GABRB2
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK3
8.078e-03	-4.82	NMDAR2_C	interpro domains	IPR018884	3	1	18521	50	GRIN2B
8.088e-03	-4.82	-	gene3d domains	3.30.70.330	245	4	14470	47	CELF2,CELF5,CELF4,RALYL
8.165e-03	-4.81	spinal_cord	COSMIC cancer mutations	spinal_cord	145	3	16828	48	NTRK3,ALK,GRIA3
8.238e-03	-4.80	NMDAR2_C	pfam domains	PF10565	3	1	17795	49	GRIN2B
8.238e-03	-4.80	FAM131	pfam domains	PF15010	3	1	17795	49	FAM131A
8.238e-03	-4.80	MAGUK_N_PEST	pfam domains	PF10608	3	1	17795	49	DLG4
8.238e-03	-4.80	Noelin-1	pfam domains	PF12308	3	1	17795	49	OLFM1
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK3
8.268e-03	-4.80	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	biological process	GO:0007157	53	2	18204	47	GRID2,TENM1
8.281e-03	-4.79	sensory perception of sound	biological process	GO:0007605	161	3	18204	47	CNTN5,ASIC2,GRM7
8.281e-03	-4.79	inorganic anion transport	biological process	GO:0015698	161	3	18204	47	GABRD,GABRB2,GABRA1
8.368e-03	-4.78	positive regulation of secretion	biological process	GO:0051047	311	4	18204	47	STXBP5,CADPS,SYT1,SYT7
8.370e-03	-4.78	T1-type_BTB	interpro domains	IPR003131	51	2	18521	50	KCNC1,KCTD16
8.434e-03	-4.78	MAPK family signaling cascades	REACTOME pathways	R-HSA-5683057	290	4	10285	29	DLG4,GRIN2B,NRG3,GRIN1
8.436e-03	-4.78	Toxicity of botulinum toxin type G (BoNT/G)	REACTOME pathways	R-HSA-5250989	3	1	10285	29	SYT1
8.436e-03	-4.78	Toxicity of botulinum toxin type B (BoNT/B)	REACTOME pathways	R-HSA-5250958	3	1	10285	29	SYT1
8.477e-03	-4.77	AP4M1 (adaptor related protein complex 4 subunit mu 1)	protein interactions	9179	55	2	19454	49	GRID2,GRIN2B
8.513e-03	-4.77	PDZ	prosite domains	PS50106	143	3	12186	36	DLG3,DLG4,RIMS2
8.533e-03	-4.76	lung-right_upper_lobe-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-non_small_cell_carcinoma	3	1	16828	48	ALK
8.533e-03	-4.76	cervical	COSMIC cancer mutations	cervical	3	1	16828	48	ALK
8.565e-03	-4.76	positive regulation of cytosolic calcium ion concentration	biological process	GO:0007204	163	3	18204	47	DLG4,GRIN1,CACNA1A
8.624e-03	-4.75	inorganic anion transmembrane transporter activity	molecular function	GO:0015103	159	3	18094	48	GABRD,GABRA1,GABRB2
8.690e-03	-4.75	Sperma_CUB_dom_sf	interpro domains	IPR035914	52	2	18521	50	CSMD2,CSMD1
8.690e-03	-4.75	Sushi	pfam domains	PF00084	51	2	17795	49	CSMD2,CSMD1
8.690e-03	-4.75	BTB_2	pfam domains	PF02214	51	2	17795	49	KCNC1,KCTD16
8.842e-03	-4.73	IRS-mediated signalling	REACTOME pathways	R-HSA-112399	294	4	10285	29	DLG4,GRIN2B,NRG3,GRIN1
8.854e-03	-4.73	import across plasma membrane	biological process	GO:0098739	165	3	18204	47	CACNA1H,CACNA1A,CACNA1G
8.881e-03	-4.72	establishment or maintenance of epithelial cell apical/basal polarity	biological process	GO:0045197	55	2	18204	47	DLG4,DLG3
9.001e-03	-4.71	positive regulation of cellular process	biological process	GO:0048522	5719	23	18204	47	SYT7,GRIN1,TENM1,CELF4,DPP10,ASIC2,DLG4,GRIN2B,CADPS,ALK,GRIK2,OLFM1,PDE2A,STXBP5,DLG3,RIMS2,KCNMA1,SYT1,KCNC1,NRXN1,GRID2,NTRK3,KCNIP2
9.015e-03	-4.71	calcium ion binding	molecular function	GO:0005509	683	6	18094	48	NRXN1,SYT1,MCTP1,KCNIP2,GRIN1,SYT7
9.120e-03	-4.70	islet_cell	COSMIC cancer mutations	islet_cell	151	3	16828	48	ALK,NTRK3,FGF12
9.120e-03	-4.70	pancreas-carcinoid-endocrine_tumour-islet_cell	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour-islet_cell	151	3	16828	48	FGF12,NTRK3,ALK
9.146e-03	-4.69	CUB	prosite domains	PS01180	49	2	12186	36	CSMD1,CSMD2
9.157e-03	-4.69	Insulin receptor signalling cascade	REACTOME pathways	R-HSA-74751	297	4	10285	29	GRIN1,DLG4,NRG3,GRIN2B
9.195e-03	-4.69	response to amyloid-beta	biological process	GO:1904645	56	2	18204	47	CACNA1A,GRIN1
9.264e-03	-4.68	IGF1R signaling cascade	REACTOME pathways	R-HSA-2428924	298	4	10285	29	GRIN1,DLG4,NRG3,GRIN2B
9.264e-03	-4.68	IRS-related events triggered by IGF1R	REACTOME pathways	R-HSA-2428928	298	4	10285	29	NRG3,GRIN2B,DLG4,GRIN1
9.328e-03	-4.67	cytoplasmic vesicle	cellular component	GO:0031410	2521	13	19108	49	SCN8A,GRIN1,GABRB2,CHRM2,CADPS,GRIA3,SYT7,MCTP1,GRIN2B,DLG4,STXBP5,GABRA1,SYT1
9.371e-03	-4.67	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME pathways	R-HSA-2404192	299	4	10285	29	GRIN2B,NRG3,DLG4,GRIN1
9.390e-03	-4.67	MAP3K11 (mitogen-activated protein kinase kinase kinase 11)	protein interactions	4296	58	2	19454	49	GRIK2,DLG4
9.390e-03	-4.67	MANEA (mannosidase endo-alpha)	protein interactions	79694	58	2	19454	49	OLFM1,GRIN1
9.472e-03	-4.66	cellular response to organonitrogen compound	biological process	GO:0071417	505	5	18204	47	GABRB2,GRIN1,HCN1,CACNA1A,PDE2A
9.512e-03	-4.66	intracellular vesicle	cellular component	GO:0097708	2527	13	19108	49	GRIA3,GABRB2,SCN8A,GRIN1,CHRM2,CADPS,STXBP5,DLG4,SYT1,GABRA1,SYT7,MCTP1,GRIN2B
9.529e-03	-4.65	LamG	smart domains	SM00282	40	2	9717	36	NRXN1,NRXN2
9.530e-03	-4.65	human chr6q16.3	chromosome location	human chr6q16.3	5	1	26134	50	GRIK2
9.586e-03	-4.65	SLC1A1 (solute carrier family 1 member 1)	protein interactions	6505	174	3	19454	49	DLG4,GRIN2B,GRIN1
9.647e-03	-4.64	hyperplasia	COSMIC cancer mutations	hyperplasia	52	2	16828	48	NTRK3,ALK
9.673e-03	-4.64	response to chemical	biological process	GO:0042221	3743	17	18204	47	CACNA1G,GRIN2B,CHRM2,DLG4,CACNA1A,ASIC2,CACNA1H,GRIN1,KCNIP2,NRG3,KCNC1,SYT1,HCN1,KCNMA1,GPHN,PDE2A,GABRB2
9.682e-03	-4.64	Sushi_SCR_CCP_dom	interpro domains	IPR000436	55	2	18521	50	CSMD1,CSMD2
9.713e-03	-4.63	Acid-sensing ion channel domain	gene3d domains	1.10.287.820	3	1	14470	47	ASIC2
9.713e-03	-4.63	acid-sensing ion channel 1 domain	gene3d domains	1.10.3590.10	3	1	14470	47	ASIC2
9.853e-03	-4.62	CALM3 (calmodulin 3)	protein interactions	808	334	4	19454	49	NTRK3,CACNA1A,ALK,GRM7
9.999e-03	-4.61	cell adhesion	biological process	GO:0007155	942	7	18204	47	DLG4,NRXN2,CNTN5,TENM1,NRXN1,GRID2,DLG3
1.002e-02	-4.60	clathrin binding	molecular function	GO:0030276	57	2	18094	48	SYT7,SYT1
1.004e-02	-4.60	Sstr2 (somatostatin receptor 2)	protein interactions	54305	4	1	19454	49	DLG3
1.004e-02	-4.60	HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)	protein interactions	10021	4	1	19454	49	HCN1
1.004e-02	-4.60	Ngfr (nerve growth factor receptor)	protein interactions	24596	4	1	19454	49	NTRK3
1.017e-02	-4.59	establishment or maintenance of apical/basal cell polarity	biological process	GO:0035088	59	2	18204	47	DLG3,DLG4
1.017e-02	-4.59	establishment or maintenance of bipolar cell polarity	biological process	GO:0061245	59	2	18204	47	DLG4,DLG3
1.019e-02	-4.59	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	3	19454	49	DLG4,DLG3,NRG3
1.022e-02	-4.58	HCN channel complex	cellular component	GO:0098855	4	1	19108	49	HCN1
1.022e-02	-4.58	clathrin-sculpted glutamate transport vesicle	cellular component	GO:0060199	4	1	19108	49	SYT1
1.022e-02	-4.58	clathrin-sculpted glutamate transport vesicle membrane	cellular component	GO:0060203	4	1	19108	49	SYT1
1.029e-02	-4.58	gamma-aminobutyric acid receptor clustering	biological process	GO:0097112	4	1	18204	47	GPHN
1.029e-02	-4.58	positive regulation of synaptic vesicle fusion to presynaptic active zone membrane	biological process	GO:0031632	4	1	18204	47	SYT1
1.029e-02	-4.58	calcium-dependent activation of synaptic vesicle fusion	biological process	GO:0099502	4	1	18204	47	SYT1
1.029e-02	-4.58	negative regulation of dendritic spine maintenance	biological process	GO:1902951	4	1	18204	47	GRIN2B
1.029e-02	-4.58	oviduct epithelium development	biological process	GO:0035846	4	1	18204	47	CSMD1
1.029e-02	-4.58	clustering of voltage-gated potassium channels	biological process	GO:0045163	4	1	18204	47	KCNIP2
1.029e-02	-4.58	globus pallidus development	biological process	GO:0021759	4	1	18204	47	KCNC1
1.029e-02	-4.58	positive regulation of potassium ion export across plasma membrane	biological process	GO:1903766	4	1	18204	47	KCNIP2
1.029e-02	-4.58	positive regulation of synaptic vesicle membrane organization	biological process	GO:1901634	4	1	18204	47	SYT1
1.029e-02	-4.58	regulation of calcium ion-dependent exocytosis of neurotransmitter	biological process	GO:1903233	4	1	18204	47	SYT1
1.029e-02	-4.58	regulation of systemic arterial blood pressure by baroreceptor feedback	biological process	GO:0003025	4	1	18204	47	ASIC2
1.029e-02	-4.58	regulation of grooming behavior	biological process	GO:2000821	4	1	18204	47	DLG4
1.029e-02	-4.58	mineralocorticoid biosynthetic process	biological process	GO:0006705	4	1	18204	47	CACNA1H
1.029e-02	-4.58	primary alcohol biosynthetic process	biological process	GO:0034309	4	1	18204	47	CACNA1H
1.035e-02	-4.57	PCDH10 (protocadherin 10)	protein interactions	57575	61	2	19454	49	DLG4,CACNA1H
1.035e-02	-4.57	GDA (guanine deaminase)	protein interactions	9615	61	2	19454	49	DLG4,DLG3
1.037e-02	-4.57	Sushi/SCR/CCP_sf	interpro domains	IPR035976	57	2	18521	50	CSMD1,CSMD2
1.037e-02	-4.57	neuron projection membrane	cellular component	GO:0032589	60	2	19108	49	KCNC1,GABRA1
1.050e-02	-4.56	membrane assembly	biological process	GO:0071709	60	2	18204	47	NRXN1,NRXN2
1.053e-02	-4.55	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	4	16828	48	GRID2,GRM7,FGF12,HCN1
1.057e-02	-4.55	adenylate cyclase inhibitor activity	molecular function	GO:0010855	4	1	18094	48	GRM7
1.057e-02	-4.55	AMPA glutamate receptor activity	molecular function	GO:0004971	4	1	18094	48	GRIA3
1.057e-02	-4.55	A-type (transient outward) potassium channel activity	molecular function	GO:0005250	4	1	18094	48	KCNIP2
1.057e-02	-4.55	calcium ion sensor activity	molecular function	GO:0061891	4	1	18094	48	SYT1
1.060e-02	-4.55	Common Pathways Underlying Drug Addiction	WikiPathways	WP2636	42	2	5310	20	GRIN1,GRIA3
1.075e-02	-4.53	salivary_gland-maxilla-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-maxilla-carcinoma-adenoid_cystic_carcinoma	55	2	16828	48	CSMD2,CADPS
1.076e-02	-4.53	LLGL2	interpro domains	IPR013577	4	1	18521	50	STXBP5
1.076e-02	-4.53	Lethal2_giant	interpro domains	IPR000664	4	1	18521	50	STXBP5
1.076e-02	-4.53	Ion_trans_N	interpro domains	IPR013621	4	1	18521	50	HCN1
1.076e-02	-4.53	Ten_N	interpro domains	IPR009471	4	1	18521	50	TENM1
1.076e-02	-4.53	K_chnl_volt-dep_Kv3	interpro domains	IPR003974	4	1	18521	50	KCNC1
1.076e-02	-4.53	YD	interpro domains	IPR006530	4	1	18521	50	TENM1
1.076e-02	-4.53	Rim-like	interpro domains	IPR039032	4	1	18521	50	RIMS2
1.076e-02	-4.53	Tox-GHH_dom	interpro domains	IPR028916	4	1	18521	50	TENM1
1.079e-02	-4.53	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	19	16828	48	CSMD2,RIMS2,GRIN2B,CACNA1A,CACNA1H,KCNT1,NTRK3,GRID2,GRIK2,FAM131A,SCN8A,CNTN5,HCN1,PDE2A,GABRB2,ALK,KCNIP2,GABRA1,DPP10
1.095e-02	-4.51	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	44	16828	48	GRID2,NTRK3,KCNT1,STXBP5,SYT1,GRIN2B,NRG3,KCNC1,HCN1,RALYL,KCTD16,CACNA1H,CELF2,SYT7,DPP10,KCNIP2,GABRB2,CHRM2,CELF5,FGF12,CNTN5,GRM7,CSMD2,CACNA1A,CADPS,GABRA1,MCTP1,PDE2A,ALK,SCN8A,GRIN1,CELF4,GRIK2,FAM131A,GRIA3,OLFM1,RIMS2,NRXN2,NRXN1,GABBR2,GABRD,CACNA1G,GPR85,KCNMA1
1.097e-02	-4.51	Tox-GHH	pfam domains	PF15636	4	1	17795	49	TENM1
1.097e-02	-4.51	Ion_trans_N	pfam domains	PF08412	4	1	17795	49	HCN1
1.097e-02	-4.51	Ten_N	pfam domains	PF06484	4	1	17795	49	TENM1
1.097e-02	-4.51	LLGL	pfam domains	PF08366	4	1	17795	49	STXBP5
1.101e-02	-4.51	KCNA4 (potassium voltage-gated channel subfamily A member 4)	protein interactions	3739	63	2	19454	49	DLG4,DLG3
1.123e-02	-4.49	HCN channels	REACTOME pathways	R-HSA-1296061	4	1	10285	29	HCN1
1.123e-02	-4.49	Activation of AMPA receptors	REACTOME pathways	R-HSA-399710	4	1	10285	29	GRIA3
1.138e-02	-4.48	sodium ion transport	biological process	GO:0006814	181	3	18204	47	ASIC2,SCN8A,HCN1
1.142e-02	-4.47	SUSHI	prosite domains	PS50923	55	2	12186	36	CSMD1,CSMD2
1.145e-02	-4.47	BKCHANNELA	prints domains	PR01449	2	1	5227	30	KCNMA1
1.146e-02	-4.47	Spermadhesin, CUB domain	gene3d domains	2.60.120.290	50	2	14470	47	CSMD2,CSMD1
1.153e-02	-4.46	synaptic vesicle recycling	biological process	GO:0036465	63	2	18204	47	SYT1,SYT7
1.160e-02	-4.46	regulation of kinase activity	biological process	GO:0043549	531	5	18204	47	DLG4,DLG3,ALK,NTRK3,TENM1
1.165e-02	-4.45	BAIAP2 (BAR/IMD domain containing adaptor protein 2)	protein interactions	10458	187	3	19454	49	NTRK3,DLG4,PDE2A
1.177e-02	-4.44	TENEURIN_N	prosite domains	PS51361	4	1	12186	36	TENM1
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	NTRK3,ALK
1.181e-02	-4.44	STX1A (syntaxin 1A)	protein interactions	6804	188	3	19454	49	STXBP5,SYT1,SYT7
1.188e-02	-4.43	cranial nerve development	biological process	GO:0021545	64	2	18204	47	KCNC1,SCN8A
1.207e-02	-4.42	cellular response to metal ion	biological process	GO:0071248	185	3	18204	47	DLG4,CACNA1H,SYT1
1.207e-02	-4.42	regulation of RNA splicing	biological process	GO:0043484	185	3	18204	47	CELF5,CELF4,CELF2
1.207e-02	-4.42	sensory perception of mechanical stimulus	biological process	GO:0050954	185	3	18204	47	CNTN5,ASIC2,GRM7
1.207e-02	-4.42	Signaling by Insulin receptor	REACTOME pathways	R-HSA-74752	322	4	10285	29	GRIN2B,NRG3,DLG4,GRIN1
1.224e-02	-4.40	membrane biogenesis	biological process	GO:0044091	65	2	18204	47	NRXN2,NRXN1
1.233e-02	-4.40	EXOC4 (exocyst complex component 4)	protein interactions	60412	191	3	19454	49	GRIN2B,DLG3,DLG4
1.246e-02	-4.38	-	gene3d domains	2.30.42.10	149	3	14470	47	DLG3,DLG4,RIMS2
1.247e-02	-4.38	head_neck	COSMIC cancer mutations	head_neck	15361	48	16828	48	CHRM2,GABRB2,CNTN5,FGF12,CELF5,DPP10,SYT7,DLG3,KCNIP2,CACNA1H,CELF2,DLG4,RALYL,KCTD16,HCN1,GPHN,NRG3,KCNC1,STXBP5,SYT1,GRIN2B,GRID2,NTRK3,KCNT1,KCNMA1,CACNA1G,GPR85,GABRD,GABBR2,NRXN2,NRXN1,OLFM1,RIMS2,FAM131A,GRIK2,CELF4,GRIN1,GRIA3,ALK,PDE2A,SCN8A,TENM1,GABRA1,CADPS,MCTP1,GRM7,CACNA1A,CSMD2
1.253e-02	-4.38	DPP10 (dipeptidyl peptidase like 10)	protein interactions	57628	5	1	19454	49	DPP10
1.253e-02	-4.38	HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)	protein interactions	57657	5	1	19454	49	HCN1
1.253e-02	-4.38	GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3)	protein interactions	2567	5	1	19454	49	GABRA1
1.253e-02	-4.38	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	49	NRXN1
1.253e-02	-4.38	Mtor (mechanistic target of rapamycin kinase)	protein interactions	56718	5	1	19454	49	GPHN
1.259e-02	-4.38	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	6	16828	48	CSMD2,CACNA1H,NRXN1,KCNT1,NRG3,GRIK2
1.259e-02	-4.38	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	6	16828	48	CSMD2,CACNA1H,KCNT1,NRXN1,GRIK2,NRG3
1.269e-02	-4.37	central_nervous_system-spinal_cord-atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	central_nervous_system-spinal_cord-atypical_teratoid-rhabdoid_tumour	60	2	16828	48	ALK,NTRK3
1.276e-02	-4.36	clathrin-sculpted monoamine transport vesicle	cellular component	GO:0070081	5	1	19108	49	SYT1
1.276e-02	-4.36	kainate selective glutamate receptor complex	cellular component	GO:0032983	5	1	19108	49	GRIK2
1.276e-02	-4.36	clathrin-sculpted monoamine transport vesicle membrane	cellular component	GO:0070083	5	1	19108	49	SYT1
1.284e-02	-4.35	cortisol metabolic process	biological process	GO:0034650	5	1	18204	47	CACNA1H
1.284e-02	-4.35	general adaptation syndrome, behavioral process	biological process	GO:0051867	5	1	18204	47	HCN1
1.284e-02	-4.35	detection of temperature stimulus involved in thermoception	biological process	GO:0050960	5	1	18204	47	GRIK2
1.284e-02	-4.35	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	47	DLG4
1.284e-02	-4.35	neuron-glial cell signaling	biological process	GO:0150099	5	1	18204	47	GABBR2
1.284e-02	-4.35	response to 2,3,7,8-tetrachlorodibenzodioxine	biological process	GO:1904612	5	1	18204	47	PDE2A
1.284e-02	-4.35	membrane depolarization during AV node cell action potential	biological process	GO:0086045	5	1	18204	47	CACNA1G
1.284e-02	-4.35	aldosterone metabolic process	biological process	GO:0032341	5	1	18204	47	CACNA1H
1.284e-02	-4.35	cGMP catabolic process	biological process	GO:0046069	5	1	18204	47	PDE2A
1.284e-02	-4.35	conditioned place preference	biological process	GO:1990708	5	1	18204	47	CSMD1
1.284e-02	-4.35	negative regulation of glutamate secretion	biological process	GO:0014050	5	1	18204	47	GRM7
1.284e-02	-4.35	regulation of neuronal action potential	biological process	GO:0098908	5	1	18204	47	FGF12
1.284e-02	-4.35	negative regulation of cell volume	biological process	GO:0045794	5	1	18204	47	KCNMA1
1.284e-02	-4.35	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	47	DLG4
1.284e-02	-4.35	membrane depolarization during SA node cell action potential	biological process	GO:0086046	5	1	18204	47	CACNA1G
1.285e-02	-4.35	TUBB2B (tubulin beta 2B class IIb)	protein interactions	347733	194	3	19454	49	GABRA1,DLG4,CACNA1A
1.293e-02	-4.35	RHS repeat-associated core	gene3d domains	2.180.10.10	4	1	14470	47	TENM1
1.299e-02	-4.34	CUB	smart domains	SM00042	47	2	9717	36	CSMD1,CSMD2
1.305e-02	-4.34	membrane organization	biological process	GO:0061024	761	6	18204	47	SYT7,GPHN,DLG4,NRXN2,KCNIP2,NRXN1
1.310e-02	-4.34	soft_tissue-striated_muscle-rhabdomyosarcoma-sclerosing	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-sclerosing	61	2	16828	48	NTRK3,ALK
1.312e-02	-4.33	VEGFA-VEGFR2 Pathway	REACTOME pathways	R-HSA-4420097	330	4	10285	29	GRIN1,DLG4,GRIN2B,NRG3
1.320e-02	-4.33	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	molecular function	GO:0086007	5	1	18094	48	CACNA1G
1.320e-02	-4.33	metal ion sensor activity	molecular function	GO:0140784	5	1	18094	48	SYT1
1.320e-02	-4.33	receptor signaling protein tyrosine kinase activator activity	molecular function	GO:0030298	5	1	18094	48	ALK
1.320e-02	-4.33	kainate selective glutamate receptor activity	molecular function	GO:0015277	5	1	18094	48	GRIK2
1.320e-02	-4.33	cyclase inhibitor activity	molecular function	GO:0010852	5	1	18094	48	GRM7
1.320e-02	-4.33	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	48	NTRK3
1.320e-02	-4.33	ER retention sequence binding	molecular function	GO:0046923	5	1	18094	48	KCNIP2
1.323e-02	-4.33	kidney	COSMIC cancer mutations	kidney	15380	48	16828	48	TENM1,SCN8A,PDE2A,ALK,MCTP1,CADPS,GABRA1,CSMD2,CACNA1A,GRM7,GABRD,KCNMA1,CACNA1G,GPR85,NRXN2,NRXN1,GABBR2,RIMS2,OLFM1,GRIA3,CELF4,GRIK2,GRIN1,FAM131A,HCN1,KCNC1,NRG3,GPHN,SYT1,GRIN2B,STXBP5,KCNT1,GRID2,NTRK3,CELF5,CNTN5,FGF12,GABRB2,CHRM2,KCNIP2,DLG3,SYT7,DPP10,CACNA1H,CELF2,KCTD16,DLG4,RALYL
1.343e-02	-4.31	Musac_Ach_rcpt	interpro domains	IPR000995	5	1	18521	50	CHRM2
1.351e-02	-4.30	sclerosing	COSMIC cancer mutations	sclerosing	62	2	16828	48	ALK,NTRK3
1.351e-02	-4.30	cellular response to xenobiotic stimulus	biological process	GO:0071466	193	3	18204	47	KCNC1,ASIC2,GRIN1
1.370e-02	-4.29	protein homooligomerization	biological process	GO:0051260	194	3	18204	47	HCN1,KCTD16,KCNC1
1.372e-02	-4.29	Type II diabetes mellitus	KEGG pathways	hsa04930	46	2	7161	28	CACNA1A,CACNA1G
1.372e-02	-4.29	Type II diabetes mellitus	KEGG pathways	ko04930	46	2	7161	28	CACNA1A,CACNA1G
1.375e-02	-4.29	Dopaminergic synapse	KEGG pathways	ko04728	130	3	7161	28	GRIA3,GRIN2B,CACNA1A
1.375e-02	-4.29	Dopaminergic synapse	KEGG pathways	hsa04728	130	3	7161	28	CACNA1A,GRIN2B,GRIA3
1.388e-02	-4.28	positive regulation of cell projection organization	biological process	GO:0031346	361	4	18204	47	DLG4,TENM1,NTRK3,ALK
1.392e-02	-4.27	meninges-meningioma	COSMIC cancer mutations	meninges-meningioma	327	4	16828	48	ALK,NTRK3,RIMS2,NRXN2
1.402e-02	-4.27	Muscarinic acetylcholine receptors	REACTOME pathways	R-HSA-390648	5	1	10285	29	CHRM2
1.408e-02	-4.26	Signaling by SCF-KIT	REACTOME pathways	R-HSA-1433557	337	4	10285	29	GRIN1,NRG3,GRIN2B,DLG4
1.422e-02	-4.25	Signaling by VEGF	REACTOME pathways	R-HSA-194138	338	4	10285	29	GRIN1,DLG4,GRIN2B,NRG3
1.427e-02	-4.25	locomotory behavior	biological process	GO:0007626	197	3	18204	47	DLG4,FGF12,ALK
1.478e-02	-4.21	maxilla	COSMIC cancer mutations	maxilla	65	2	16828	48	CSMD2,CADPS
1.486e-02	-4.21	protein-RNA complex assembly	biological process	GO:0022618	200	3	18204	47	CELF5,CELF4,CELF2
1.494e-02	-4.20	carboxylic acid binding	molecular function	GO:0031406	195	3	18094	48	GRIN1,GRIN2B,GRM7
1.499e-02	-4.20	Nicotine Activity on Chromaffin Cells	WikiPathways	WP1603	4	1	5310	20	CACNA1G
1.502e-02	-4.20	NLGN4X (neuroligin 4 X-linked)	protein interactions	57502	6	1	19454	49	DLG4
1.502e-02	-4.20	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	49	NRXN1
1.502e-02	-4.20	TMEM8B (transmembrane protein 8B)	protein interactions	51754	6	1	19454	49	CHRM2
1.502e-02	-4.20	GRID2IP (Grid2 interacting protein)	protein interactions	392862	6	1	19454	49	GRID2
1.502e-02	-4.20	Nos1 (nitric oxide synthase 1)	protein interactions	24598	6	1	19454	49	DLG4
1.504e-02	-4.20	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	25	16828	48	NRG3,CADPS,KCNC1,ALK,SCN8A,NTRK3,GRID2,KCNT1,STXBP5,GRM7,CSMD2,GRIN2B,CACNA1A,NRXN2,GABRB2,CACNA1G,CNTN5,CELF4,GRIK2,DLG4,FAM131A,GRIA3,CACNA1H,OLFM1,CELF2
1.506e-02	-4.20	KCHANNEL	prints domains	PR00169	33	2	5227	30	KCNMA1,KCNC1
1.509e-02	-4.19	response to nitrogen compound	biological process	GO:1901698	1021	7	18204	47	KCNC1,CHRM2,PDE2A,CACNA1A,HCN1,GRIN1,GABRB2
1.516e-02	-4.19	meningioma	COSMIC cancer mutations	meningioma	514	5	16828	48	NTRK3,ALK,GRM7,NRXN2,RIMS2
1.516e-02	-4.19	meninges	COSMIC cancer mutations	meninges	514	5	16828	48	GRM7,ALK,NTRK3,RIMS2,NRXN2
1.524e-02	-4.18	phosphatidylserine binding	molecular function	GO:0001786	71	2	18094	48	SYT7,SYT1
1.526e-02	-4.18	heart valve development	biological process	GO:0003170	73	2	18204	47	OLFM1,PDE2A
1.529e-02	-4.18	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	3	16828	48	SYT1,NRG3,GRID2
1.534e-02	-4.18	UNC5B (unc-5 netrin receptor B)	protein interactions	219699	75	2	19454	49	ALK,NTRK3
1.539e-02	-4.17	Mo-molybdopterin cofactor biosynthetic process	biological process	GO:0006777	6	1	18204	47	GPHN
1.539e-02	-4.17	negative regulation of cGMP-mediated signaling	biological process	GO:0010754	6	1	18204	47	PDE2A
1.539e-02	-4.17	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	47	NRG3
1.539e-02	-4.17	molybdopterin cofactor biosynthetic process	biological process	GO:0032324	6	1	18204	47	GPHN
1.539e-02	-4.17	oviduct development	biological process	GO:0060066	6	1	18204	47	CSMD1
1.539e-02	-4.17	Mo-molybdopterin cofactor metabolic process	biological process	GO:0019720	6	1	18204	47	GPHN
1.539e-02	-4.17	mineralocorticoid metabolic process	biological process	GO:0008212	6	1	18204	47	CACNA1H
1.539e-02	-4.17	positive regulation of dopamine secretion	biological process	GO:0033603	6	1	18204	47	SYT1
1.539e-02	-4.17	positive regulation of inhibitory postsynaptic potential	biological process	GO:0097151	6	1	18204	47	RIMS2
1.539e-02	-4.17	general adaptation syndrome	biological process	GO:0051866	6	1	18204	47	HCN1
1.539e-02	-4.17	prosthetic group metabolic process	biological process	GO:0051189	6	1	18204	47	GPHN
1.539e-02	-4.17	mammary gland formation	biological process	GO:0060592	6	1	18204	47	NRG3
1.539e-02	-4.17	neuronal signal transduction	biological process	GO:0023041	6	1	18204	47	OLFM1
1.539e-02	-4.17	molybdopterin cofactor metabolic process	biological process	GO:0043545	6	1	18204	47	GPHN
1.539e-02	-4.17	cellular response to histamine	biological process	GO:0071420	6	1	18204	47	GABRB2
1.547e-02	-4.17	heart development	biological process	GO:0007507	571	5	18204	47	FGF12,PDE2A,CACNA1G,OLFM1,NTRK3
1.551e-02	-4.17	pancreas-carcinoma-adenocarcinoma	COSMIC cancer mutations	pancreas-carcinoma-adenocarcinoma	517	5	16828	48	CHRM2,GRIA3,KCNT1,CSMD2,KCNC1
1.562e-02	-4.16	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	25	16828	48	GRID2,GRM7,STXBP5,SYT1,GRIN2B,CSMD2,CADPS,NRG3,MCTP1,ALK,PDE2A,HCN1,GRIN1,GRIK2,CELF4,KCTD16,RIMS2,DPP10,SYT7,NRXN1,NRXN2,GABRB2,GPR85,KCNMA1,CELF5
1.563e-02	-4.16	PDZ	smart domains	SM00228	143	3	9717	36	DLG3,DLG4,RIMS2
1.567e-02	-4.16	MACF1 (microtubule actin crosslinking factor 1)	protein interactions	23499	209	3	19454	49	TENM1,NRXN1,NRXN2
1.569e-02	-4.16	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	25	16828	48	NRG3,CADPS,SYT7,DPP10,NRXN1,NRXN2,MCTP1,PDE2A,GABRB2,ALK,CELF5,HCN1,KCNMA1,GPR85,GRIN1,CELF4,GRIK2,GRID2,KCTD16,STXBP5,GRM7,CSMD2,RIMS2,SYT1,GRIN2B
1.579e-02	-4.15	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	19	16828	48	TENM1,HCN1,ALK,NRXN2,MCTP1,GABBR2,CADPS,CSMD2,CACNA1A,RIMS2,CACNA1H,STXBP5,GRM7,KCNT1,KCTD16,GRIK2,GRID2,NTRK3,DLG4
1.581e-02	-4.15	molybdopterin cofactor binding	molecular function	GO:0043546	6	1	18094	48	GPHN
1.581e-02	-4.15	D1 dopamine receptor binding	molecular function	GO:0031748	6	1	18094	48	DLG4
1.584e-02	-4.15	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	47	16828	48	GPHN,NRG3,KCNC1,HCN1,NTRK3,GRID2,KCNT1,STXBP5,SYT1,GRIN2B,DPP10,DLG3,SYT7,KCNIP2,CHRM2,GABRB2,CNTN5,FGF12,CELF5,RALYL,DLG4,KCTD16,CELF2,CACNA1H,CADPS,GABRA1,MCTP1,ALK,PDE2A,SCN8A,TENM1,GRM7,CACNA1A,CSMD2,GABBR2,NRXN1,NRXN2,CACNA1G,KCNMA1,GPR85,GABRD,CELF4,GRIN1,GRIK2,GRIA3,OLFM1,RIMS2
1.584e-02	-4.15	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	47	16828	48	CACNA1H,CELF2,RALYL,DLG4,KCTD16,GABRB2,CHRM2,CELF5,CNTN5,FGF12,DLG3,SYT7,DPP10,KCNIP2,STXBP5,SYT1,GRIN2B,NTRK3,GRID2,KCNT1,HCN1,NRG3,GPHN,KCNC1,OLFM1,RIMS2,GRIK2,CELF4,GRIN1,GRIA3,GABRD,CACNA1G,KCNMA1,GPR85,NRXN2,NRXN1,GABBR2,GRM7,CSMD2,CACNA1A,PDE2A,ALK,TENM1,SCN8A,GABRA1,CADPS,MCTP1
1.587e-02	-4.14	clathrin-coated endocytic vesicle membrane	cellular component	GO:0030669	75	2	19108	49	SYT1,CHRM2
1.587e-02	-4.14	neuromuscular junction	cellular component	GO:0031594	75	2	19108	49	DLG3,DLG4
1.597e-02	-4.14	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	20	CACNA1A,SYT1
1.607e-02	-4.13	EPHB2 (EPH receptor B2)	protein interactions	2048	211	3	19454	49	GRIN2B,GRIN1,ALK
1.609e-02	-4.13	Na_trans_cytopl	interpro domains	IPR024583	6	1	18521	50	SCN8A
1.609e-02	-4.13	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	1	18521	50	NRXN1
1.609e-02	-4.13	hnRNP_C	interpro domains	IPR017347	6	1	18521	50	RALYL
1.609e-02	-4.13	Gabra-1-6_TM	interpro domains	IPR047024	6	1	18521	50	GABRA1
1.609e-02	-4.13	Peptidase_S9B_N	interpro domains	IPR002469	6	1	18521	50	DPP10
1.609e-02	-4.13	GABAAa_rcpt	interpro domains	IPR001390	6	1	18521	50	GABRA1
1.629e-02	-4.12	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	4	10285	29	DLG4,GRIN2B,NRG3,GRIN1
1.634e-02	-4.11	CCP	smart domains	SM00032	53	2	9717	36	CSMD2,CSMD1
1.640e-02	-4.11	MAPK signaling pathway	KEGG pathways	ko04010	255	4	7161	28	CACNA1A,FGF12,CACNA1H,CACNA1G
1.640e-02	-4.11	MAPK signaling pathway	KEGG pathways	hsa04010	255	4	7161	28	CACNA1A,CACNA1G,CACNA1H,FGF12
1.641e-02	-4.11	Syndecan	pfam domains	PF01034	6	1	17795	49	NRXN1
1.641e-02	-4.11	DPPIV_N	pfam domains	PF00930	6	1	17795	49	DPP10
1.641e-02	-4.11	Na_trans_cytopl	pfam domains	PF11933	6	1	17795	49	SCN8A
1.652e-02	-4.10	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	49	DLG4,GRIN1
1.670e-02	-4.09	Amyotrophic lateral sclerosis (ALS)	KEGG pathways	ko05014	51	2	7161	28	GRIN2B,GRIN1
1.670e-02	-4.09	Amyotrophic lateral sclerosis (ALS)	KEGG pathways	hsa05014	51	2	7161	28	GRIN1,GRIN2B
1.680e-02	-4.09	Molybdenum cofactor biosynthesis	REACTOME pathways	R-HSA-947581	6	1	10285	29	GPHN
1.688e-02	-4.08	negative regulation of endocytosis	biological process	GO:0045806	77	2	18204	47	MCTP1,DLG4
1.691e-02	-4.08	protein-RNA complex organization	biological process	GO:0071826	210	3	18204	47	CELF5,CELF4,CELF2
1.691e-02	-4.08	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	4	10285	29	DLG4,NRG3,GRIN2B,GRIN1
1.700e-02	-4.07	ganglioneuroma	COSMIC cancer mutations	ganglioneuroma	6	1	16828	48	ALK
1.700e-02	-4.07	genital_tract-germ_cell_tumour-teratoma	COSMIC cancer mutations	genital_tract-germ_cell_tumour-teratoma	6	1	16828	48	ALK
1.700e-02	-4.07	autonomic_ganglia-ganglioneuroma	COSMIC cancer mutations	autonomic_ganglia-ganglioneuroma	6	1	16828	48	ALK
1.712e-02	-4.07	GABAARBETA	prints domains	PR01160	3	1	5227	30	GABRB2
1.712e-02	-4.07	NTKRECEPTOR	prints domains	PR01939	3	1	5227	30	NTRK3
1.712e-02	-4.07	GABABRECEPTR	prints domains	PR01176	3	1	5227	30	GABBR2
1.715e-02	-4.07	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	29	16828	48	CELF2,OLFM1,CACNA1H,GRIN1,GRIK2,CELF4,FAM131A,DLG4,GRIA3,GABRB2,CNTN5,CACNA1G,NRXN1,NRXN2,GABBR2,STXBP5,GRM7,CSMD2,CACNA1A,GRIN2B,NTRK3,GRID2,KCNT1,ALK,TENM1,SCN8A,CADPS,NRG3,KCNC1
1.728e-02	-4.06	calmodulin binding	molecular function	GO:0005516	206	3	18094	48	GRIN1,SYT1,SYT7
1.729e-02	-4.06	PRKCA (protein kinase C alpha)	protein interactions	5578	395	4	19454	49	GRM7,DLG4,GRIN2B,GRIN1
1.733e-02	-4.06	PPP1CA (protein phosphatase 1 catalytic subunit alpha)	protein interactions	100009298	80	2	19454	49	CSMD1,DLG3
1.733e-02	-4.06	STX2 (syntaxin 2)	protein interactions	2054	80	2	19454	49	SYT7,SYT1
1.750e-02	-4.05	organic acid binding	molecular function	GO:0043177	207	3	18094	48	GRIN1,GRM7,GRIN2B
1.750e-02	-4.05	Dlg4 (discs large MAGUK scaffold protein 4)	protein interactions	13385	7	1	19454	49	GRIN1
1.750e-02	-4.05	HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)	protein interactions	610	7	1	19454	49	HCN1
1.750e-02	-4.05	KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1)	protein interactions	3779	7	1	19454	49	KCNMA1
1.750e-02	-4.05	SV2B (synaptic vesicle glycoprotein 2B)	protein interactions	9899	7	1	19454	49	SYT1
1.750e-02	-4.05	RIMBP2 (RIMS binding protein 2)	protein interactions	23504	7	1	19454	49	CACNA1A
1.751e-02	-4.05	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	9	16828	48	ALK,GRM7,FGF12,HCN1,TENM1,GRID2,NRG3,GABBR2,MCTP1
1.752e-02	-4.04	central_nervous_system-brain-glioma	COSMIC cancer mutations	central_nervous_system-brain-glioma	15470	48	16828	48	CSMD2,CACNA1A,GRM7,TENM1,SCN8A,PDE2A,ALK,MCTP1,CADPS,GABRA1,RIMS2,OLFM1,GRIA3,GRIK2,CELF4,GRIN1,FAM131A,GABRD,KCNMA1,CACNA1G,GPR85,NRXN1,NRXN2,GABBR2,SYT1,GRIN2B,STXBP5,KCNT1,NTRK3,GRID2,HCN1,KCNC1,NRG3,GPHN,CELF2,CACNA1H,KCTD16,RALYL,DLG4,CELF5,CNTN5,FGF12,GABRB2,CHRM2,KCNIP2,DLG3,SYT7,DPP10
1.777e-02	-4.03	positive regulation of transmembrane transport	biological process	GO:0034764	214	3	18204	47	KCNIP2,KCNC1,GRIN1
1.777e-02	-4.03	cellular response to inorganic substance	biological process	GO:0071241	214	3	18204	47	DLG4,SYT1,CACNA1H
1.777e-02	-4.03	regulation of monoatomic ion transmembrane transporter activity	biological process	GO:0032412	214	3	18204	47	FGF12,DLG4,KCNIP2
1.782e-02	-4.03	G protein-coupled receptor dimeric complex	cellular component	GO:0038037	7	1	19108	49	GABBR2
1.782e-02	-4.03	cerebellar mossy fiber	cellular component	GO:0044300	7	1	19108	49	DLG4
1.794e-02	-4.02	regulation of synaptic vesicle priming	biological process	GO:0010807	7	1	18204	47	STXBP5
1.794e-02	-4.02	cellular response to cGMP	biological process	GO:0071321	7	1	18204	47	PDE2A
1.794e-02	-4.02	SA node cell action potential	biological process	GO:0086015	7	1	18204	47	CACNA1G
1.794e-02	-4.02	modulation of inhibitory postsynaptic potential	biological process	GO:0098828	7	1	18204	47	RIMS2
1.794e-02	-4.02	mammary gland branching involved in pregnancy	biological process	GO:0060745	7	1	18204	47	CSMD1
1.794e-02	-4.02	cerebellar granule cell differentiation	biological process	GO:0021707	7	1	18204	47	GRID2
1.794e-02	-4.02	SA node cell to atrial cardiac muscle cell signaling	biological process	GO:0086018	7	1	18204	47	CACNA1G
1.794e-02	-4.02	AV node cell to bundle of His cell signaling	biological process	GO:0086027	7	1	18204	47	CACNA1G
1.794e-02	-4.02	positive regulation of long-term synaptic depression	biological process	GO:1900454	7	1	18204	47	GRID2
1.794e-02	-4.02	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	47	NRG3
1.794e-02	-4.02	hydrocarbon metabolic process	biological process	GO:0120252	7	1	18204	47	GRIN1
1.794e-02	-4.02	AV node cell action potential	biological process	GO:0086016	7	1	18204	47	CACNA1G
1.794e-02	-4.02	cerebellar granular layer formation	biological process	GO:0021684	7	1	18204	47	GRID2
1.794e-02	-4.02	glucocorticoid biosynthetic process	biological process	GO:0006704	7	1	18204	47	CACNA1H
1.794e-02	-4.02	dense core granule exocytosis	biological process	GO:1990504	7	1	18204	47	CADPS
1.794e-02	-4.02	urinary bladder smooth muscle contraction	biological process	GO:0014832	7	1	18204	47	KCNMA1
1.816e-02	-4.01	TUBA8 (tubulin alpha 8)	protein interactions	51807	82	2	19454	49	GRM7,GABRA1
1.821e-02	-4.01	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	4	10285	29	GRIN1,NRG3,GRIN2B,DLG4
1.838e-02	-4.00	NSF (N-ethylmaleimide sensitive factor, vesicle fusing ATPase)	protein interactions	4905	222	3	19454	49	GRIA3,NTRK3,GABBR2
1.839e-02	-4.00	DUF1041	smart domains	SM01145	5	1	9717	36	CADPS
1.843e-02	-3.99	TPR domain binding	molecular function	GO:0030911	7	1	18094	48	PDE2A
1.843e-02	-3.99	G protein-coupled acetylcholine receptor activity	molecular function	GO:0016907	7	1	18094	48	CHRM2
1.844e-02	-3.99	regulation of cell junction assembly	biological process	GO:1901888	217	3	18204	47	NRXN1,GRID2,ASIC2
1.858e-02	-3.99	ARHGEF10 (Rho guanine nucleotide exchange factor 10)	protein interactions	9639	83	2	19454	49	NTRK3,ALK
1.875e-02	-3.98	VDCC_a1su_IQ	interpro domains	IPR014873	7	1	18521	50	CACNA1A
1.875e-02	-3.98	Hud_Sxl_RNA	interpro domains	IPR002343	7	1	18521	50	CELF2
1.875e-02	-3.98	GAF	interpro domains	IPR003018	7	1	18521	50	PDE2A
1.875e-02	-3.98	GPHH_dom	interpro domains	IPR031649	7	1	18521	50	CACNA1A
1.875e-02	-3.98	MUN_dom	interpro domains	IPR010439	7	1	18521	50	CADPS
1.875e-02	-3.98	ENaC_chordates	interpro domains	IPR004724	7	1	18521	50	ASIC2
1.875e-02	-3.98	Munc13_1	interpro domains	IPR014770	7	1	18521	50	CADPS
1.897e-02	-3.96	human chr11q22.1	chromosome location	human chr11q22.1	10	1	26134	50	CNTN5
1.897e-02	-3.96	human chr8q21.2	chromosome location	human chr8q21.2	10	1	26134	50	RALYL
1.900e-02	-3.96	RAB27A (RAB27A, member RAS oncogene family)	protein interactions	5873	84	2	19454	49	SYT1,RIMS2
1.900e-02	-3.96	MAPK12 (mitogen-activated protein kinase 12)	protein interactions	6300	84	2	19454	49	DLG4,DLG3
1.910e-02	-3.96	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	9	16828	48	GABBR2,NRXN1,NRXN2,CADPS,NTRK3,RIMS2,CELF5,GRM7,ALK
1.910e-02	-3.96	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	9	16828	48	GABBR2,NRXN1,NRXN2,CADPS,NTRK3,RIMS2,CELF5,ALK,GRM7
1.911e-02	-3.96	secretory vesicle	cellular component	GO:0099503	1076	7	19108	49	CADPS,MCTP1,SYT7,GRIN1,SYT1,STXBP5,DLG4
1.912e-02	-3.96	MUN	pfam domains	PF06292	7	1	17795	49	CADPS
1.912e-02	-3.96	GPHH	pfam domains	PF16905	7	1	17795	49	CACNA1A
1.912e-02	-3.96	Ca_chan_IQ	pfam domains	PF08763	7	1	17795	49	CACNA1A
1.912e-02	-3.96	GAF	pfam domains	PF01590	7	1	17795	49	PDE2A
1.919e-02	-3.95	humerus	COSMIC cancer mutations	humerus	546	5	16828	48	GRID2,GRM7,TENM1,FGF12,HCN1
1.923e-02	-3.95	Muscle contraction	REACTOME pathways	R-HSA-397014	204	3	10285	29	KCNIP2,FGF12,SCN8A
1.933e-02	-3.95	Dipeptidylpeptidase IV, N-terminal domain	gene3d domains	2.140.10.30	6	1	14470	47	DPP10
1.939e-02	-3.94	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	4	10285	29	GRIN2B,NRG3,DLG4,GRIN1
1.944e-02	-3.94	regulation of amine transport	biological process	GO:0051952	83	2	18204	47	SYT1,GRM7
1.944e-02	-3.94	positive regulation of MAP kinase activity	biological process	GO:0043406	83	2	18204	47	NTRK3,TENM1
1.954e-02	-3.94	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	48	ALK,NTRK3
1.956e-02	-3.93	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	4	10285	29	GRIN1,DLG4,GRIN2B,NRG3
1.957e-02	-3.93	regulation of transmembrane transporter activity	biological process	GO:0022898	222	3	18204	47	KCNIP2,FGF12,DLG4
1.958e-02	-3.93	Phase 1 - inactivation of fast Na+ channels	REACTOME pathways	R-HSA-5576894	7	1	10285	29	KCNIP2
1.960e-02	-3.93	skin-leg-malignant_melanoma	COSMIC cancer mutations	skin-leg-malignant_melanoma	549	5	16828	48	CSMD2,NTRK3,NRG3,CADPS,CELF4
1.964e-02	-3.93	regulation of cell growth	biological process	GO:0001558	401	4	18204	47	RIMS2,NRG3,OLFM1,SYT1
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	NTRK3,ALK
1.980e-02	-3.92	autonomic_ganglia-ganglioneuroblastoma	COSMIC cancer mutations	autonomic_ganglia-ganglioneuroblastoma	7	1	16828	48	ALK
1.980e-02	-3.92	stomach-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	stomach-carcinoma-mixed_adenosquamous_carcinoma	7	1	16828	48	NTRK3
1.980e-02	-3.92	bone-scapula-chordoma	COSMIC cancer mutations	bone-scapula-chordoma	7	1	16828	48	ALK
1.980e-02	-3.92	bone-extraskeletal-chordoma	COSMIC cancer mutations	bone-extraskeletal-chordoma	7	1	16828	48	ALK
1.986e-02	-3.92	FAM171A1 (family with sequence similarity 171 member A1)	protein interactions	221061	86	2	19454	49	ALK,NTRK3
1.986e-02	-3.92	EGLN1 (egl-9 family hypoxia inducible factor 1)	protein interactions	54583	86	2	19454	49	ALK,NTRK3
1.986e-02	-3.92	HLA-F (major histocompatibility complex, class I, F)	protein interactions	3134	86	2	19454	49	NTRK3,GRIA3
1.989e-02	-3.92	peripheral nervous system development	biological process	GO:0007422	84	2	18204	47	SCN8A,ASIC2
1.998e-02	-3.91	GJC2 (gap junction protein gamma 2)	protein interactions	57165	8	1	19454	49	CHRM2
1.998e-02	-3.91	PEX5L (peroxisomal biogenesis factor 5 like)	protein interactions	51555	8	1	19454	49	HCN1
1.998e-02	-3.91	ATP9B (ATPase phospholipid transporting 9B (putative))	protein interactions	374868	8	1	19454	49	PDE2A
1.998e-02	-3.91	KMO (kynurenine 3-monooxygenase)	protein interactions	8564	8	1	19454	49	GPHN
1.998e-02	-3.91	DHRS11 (dehydrogenase/reductase 11)	protein interactions	79154	8	1	19454	49	DLG3
1.998e-02	-3.91	GRM4 (glutamate metabotropic receptor 4)	protein interactions	2914	8	1	19454	49	GRM7
1.998e-02	-3.91	SAG (S-antigen visual arrestin)	protein interactions	6295	8	1	19454	49	CHRM2
1.998e-02	-3.91	RASSF4 (Ras association domain family member 4)	protein interactions	83937	8	1	19454	49	DLG4
1.998e-02	-3.91	GRIK4 (glutamate ionotropic receptor kainate type subunit 4)	protein interactions	2900	8	1	19454	49	GRIK2
2.010e-02	-3.91	thyroid-carcinoma-Hurthle_cell_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-Hurthle_cell_carcinoma	203	3	16828	48	SCN8A,GABRD,SYT7
2.010e-02	-3.91	Hurthle_cell_carcinoma	COSMIC cancer mutations	Hurthle_cell_carcinoma	203	3	16828	48	SCN8A,GABRD,SYT7
2.027e-02	-3.90	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	4	10285	29	DLG4,NRG3,GRIN2B,GRIN1
2.034e-02	-3.90	clathrin-sculpted gamma-aminobutyric acid transport vesicle	cellular component	GO:0061200	8	1	19108	49	SYT1
2.034e-02	-3.90	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	cellular component	GO:0061202	8	1	19108	49	SYT1
2.034e-02	-3.90	cytoskeleton of presynaptic active zone	cellular component	GO:0048788	8	1	19108	49	RIMS2
2.047e-02	-3.89	positive regulation of neuron projection arborization	biological process	GO:0150012	8	1	18204	47	DLG4
2.047e-02	-3.89	regulation of glucagon secretion	biological process	GO:0070092	8	1	18204	47	SYT7
2.047e-02	-3.89	cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:0036006	8	1	18204	47	PDE2A
2.047e-02	-3.89	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	biological process	GO:0007207	8	1	18204	47	CHRM2
2.047e-02	-3.89	positive regulation of vesicle fusion	biological process	GO:0031340	8	1	18204	47	SYT1
2.047e-02	-3.89	adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	biological process	GO:0007197	8	1	18204	47	CHRM2
2.047e-02	-3.89	atrioventricular valve formation	biological process	GO:0003190	8	1	18204	47	OLFM1
2.047e-02	-3.89	thermoception	biological process	GO:0050955	8	1	18204	47	GRIK2
2.047e-02	-3.89	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	47	NRG3
2.047e-02	-3.89	negative regulation of synaptic transmission, glutamatergic	biological process	GO:0051967	8	1	18204	47	GRIK2
2.047e-02	-3.89	micturition	biological process	GO:0060073	8	1	18204	47	KCNMA1
2.049e-02	-3.89	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	29	ASIC2,GABRB2,GABRA1
2.050e-02	-3.89	MHD1	prosite domains	PS51258	7	1	12186	36	CADPS
2.062e-02	-3.88	SEC23A (SEC23 homolog A, COPII coat complex component)	protein interactions	10484	232	3	19454	49	CADPS,ALK,NTRK3
2.078e-02	-3.87	response to cAMP	biological process	GO:0051591	86	2	18204	47	HCN1,PDE2A
2.092e-02	-3.87	phosphatidylinositol-4,5-bisphosphate binding	molecular function	GO:0005546	84	2	18094	48	SYT7,SYT1
2.103e-02	-3.86	adenylate cyclase regulator activity	molecular function	GO:0010854	8	1	18094	48	GRM7
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	SCN8A
2.109e-02	-3.86	PRKCB (protein kinase C beta)	protein interactions	5579	234	3	19454	49	GABRB2,GRIN2B,GRIN1
2.117e-02	-3.86	positive regulation of phosphorylation	biological process	GO:0042327	619	5	18204	47	TENM1,ALK,DLG3,NTRK3,DLG4
2.124e-02	-3.85	associative learning	biological process	GO:0008306	87	2	18204	47	GRIN1,CSMD1
2.126e-02	-3.85	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	8	16828	48	CSMD2,GRIN2B,RIMS2,GRM7,ALK,KCTD16,GRID2,DPP10
2.127e-02	-3.85	ConA-like_dom_sf	interpro domains	IPR013320	219	3	18521	50	NRXN1,NRXN2,ALK
2.133e-02	-3.85	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	46	16828	48	HCN1,NRG3,GPHN,KCNC1,STXBP5,SYT1,GRIN2B,NTRK3,GRID2,KCNT1,GABRB2,CHRM2,CELF5,CNTN5,FGF12,SYT7,DPP10,KCNIP2,CELF2,CACNA1H,DLG4,RALYL,KCTD16,PDE2A,ALK,TENM1,SCN8A,GABRA1,CADPS,MCTP1,GRM7,CSMD2,CACNA1A,GABRD,KCNMA1,CACNA1G,NRXN1,NRXN2,GABBR2,OLFM1,RIMS2,GRIK2,GRIN1,CELF4,FAM131A,GRIA3
2.140e-02	-3.84	ENaC_CS	interpro domains	IPR020903	8	1	18521	50	ASIC2
2.140e-02	-3.84	GAF-like_dom_sf	interpro domains	IPR029016	8	1	18521	50	PDE2A
2.140e-02	-3.84	GPCR_3_mtglu_rcpt	interpro domains	IPR000162	8	1	18521	50	GRM7
2.143e-02	-3.84	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	18	16828	48	KCNIP2,DPP10,GABRA1,SCN8A,HCN1,CNTN5,ALK,GABRB2,KCNT1,FAM131A,GRID2,NTRK3,GRIK2,RIMS2,GRIN2B,CACNA1A,CSMD2,CACNA1H
2.148e-02	-3.84	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	18	16828	48	GABRB2,ALK,CNTN5,HCN1,SCN8A,GABRA1,DPP10,KCNIP2,CACNA1H,CSMD2,CACNA1A,RIMS2,GRIN2B,GRIK2,NTRK3,GRID2,FAM131A,KCNT1
2.169e-02	-3.83	positive regulation of peptidyl-serine phosphorylation	biological process	GO:0033138	88	2	18204	47	NTRK3,TENM1
2.170e-02	-3.83	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	20	GABRA1,GRIN1,CHRM2
2.189e-02	-3.82	neuron projection cytoplasm	cellular component	GO:0120111	89	2	19108	49	GRIK2,DLG4
2.202e-02	-3.82	neck	COSMIC cancer mutations	neck	1231	8	16828	48	CSMD2,GRIN2B,RIMS2,ALK,GRM7,KCTD16,GRID2,DPP10
2.227e-02	-3.80	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	4	10285	29	GRIN1,DLG4,NRG3,GRIN2B
2.244e-02	-3.80	stomach	COSMIC cancer mutations	stomach	15550	48	16828	48	KCTD16,RALYL,DLG4,CELF2,CACNA1H,KCNIP2,DPP10,DLG3,SYT7,FGF12,CNTN5,CELF5,CHRM2,GABRB2,KCNT1,NTRK3,GRID2,GRIN2B,SYT1,STXBP5,KCNC1,GPHN,NRG3,HCN1,GRIA3,FAM131A,GRIN1,CELF4,GRIK2,RIMS2,OLFM1,GABBR2,NRXN1,NRXN2,KCNMA1,CACNA1G,GPR85,GABRD,CACNA1A,CSMD2,GRM7,MCTP1,CADPS,GABRA1,SCN8A,TENM1,ALK,PDE2A
2.245e-02	-3.80	KCNG3 (potassium voltage-gated channel modifier subfamily G member 3)	protein interactions	170850	9	1	19454	49	KCNC1
2.245e-02	-3.80	KCNV2 (potassium voltage-gated channel modifier subfamily V member 2)	protein interactions	169522	9	1	19454	49	KCNC1
2.245e-02	-3.80	MPND (MPN domain containing)	protein interactions	84954	9	1	19454	49	DLG4
2.245e-02	-3.80	GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2)	protein interactions	2561	9	1	19454	49	GABRA1
2.245e-02	-3.80	CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1)	protein interactions	55450	9	1	19454	49	GRIN2B
2.252e-02	-3.79	-	gene3d domains	6.10.250.2180	7	1	14470	47	CACNA1A
2.252e-02	-3.79	-	gene3d domains	6.10.250.2500	7	1	14470	47	CACNA1A
2.260e-02	-3.79	ganglioneuroblastoma	COSMIC cancer mutations	ganglioneuroblastoma	8	1	16828	48	ALK
2.260e-02	-3.79	papillary_adenocarcinoma	COSMIC cancer mutations	papillary_adenocarcinoma	8	1	16828	48	NTRK3
2.260e-02	-3.79	thymus-thymic_carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	thymus-thymic_carcinoma-squamous_cell_carcinoma	8	1	16828	48	ALK
2.260e-02	-3.79	stomach-carcinoma-papillary_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-papillary_adenocarcinoma	8	1	16828	48	NTRK3
2.272e-02	-3.78	human chr6q24.3	chromosome location	human chr6q24.3	12	1	26134	50	STXBP5
2.277e-02	-3.78	LETHAL2GIANT	prints domains	PR00962	4	1	5227	30	STXBP5
2.277e-02	-3.78	SHAWCHANNEL	prints domains	PR01498	4	1	5227	30	KCNC1
2.277e-02	-3.78	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	49	GRIN2B,NTRK3,DLG4
2.278e-02	-3.78	central_nervous_system-brain-atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	central_nervous_system-brain-atypical_teratoid-rhabdoid_tumour	213	3	16828	48	NTRK3,GABRB2,ALK
2.278e-02	-3.78	atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	atypical_teratoid-rhabdoid_tumour	213	3	16828	48	GABRB2,NTRK3,ALK
2.285e-02	-3.78	chromaffin granule membrane	cellular component	GO:0042584	9	1	19108	49	SYT1
2.300e-02	-3.77	adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	biological process	GO:0007196	9	1	18204	47	GRM7
2.300e-02	-3.77	vesicle-mediated cholesterol transport	biological process	GO:0090119	9	1	18204	47	SYT7
2.300e-02	-3.77	response to cGMP	biological process	GO:0070305	9	1	18204	47	PDE2A
2.300e-02	-3.77	cerebellar granular layer morphogenesis	biological process	GO:0021683	9	1	18204	47	GRID2
2.300e-02	-3.77	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	47	NRXN1
2.300e-02	-3.77	C21-steroid hormone biosynthetic process	biological process	GO:0006700	9	1	18204	47	CACNA1H
2.300e-02	-3.77	SA node cell to atrial cardiac muscle cell communication	biological process	GO:0086070	9	1	18204	47	CACNA1G
2.300e-02	-3.77	negative regulation of cAMP-mediated signaling	biological process	GO:0043951	9	1	18204	47	PDE2A
2.300e-02	-3.77	sensory perception of sour taste	biological process	GO:0050915	9	1	18204	47	ASIC2
2.300e-02	-3.77	regulation of potassium ion export across plasma membrane	biological process	GO:1903764	9	1	18204	47	KCNIP2
2.300e-02	-3.77	urinary tract smooth muscle contraction	biological process	GO:0014848	9	1	18204	47	KCNMA1
2.340e-02	-3.76	ASC	prosite domains	PS01206	8	1	12186	36	ASIC2
2.344e-02	-3.75	positive regulation of catalytic activity	biological process	GO:0043085	868	6	18204	47	DLG3,TENM1,ALK,NTRK3,GRIN2B,DLG4
2.345e-02	-3.75	TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1)	protein interactions	85461	94	2	19454	49	GRIN2B,DLG4
2.355e-02	-3.75	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	11	16828	48	GRIK2,GRID2,CSMD2,GRIN2B,SYT1,GRM7,NRG3,CADPS,KCNMA1,PDE2A,ALK
2.355e-02	-3.75	mucosal	COSMIC cancer mutations	mucosal	2009	11	16828	48	GRIN2B,SYT1,CSMD2,GRM7,GRIK2,GRID2,KCNMA1,ALK,PDE2A,CADPS,NRG3
2.359e-02	-3.75	transport vesicle membrane	cellular component	GO:0030658	240	3	19108	49	MCTP1,SYT7,SYT1
2.363e-02	-3.75	adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	molecular function	GO:0001640	9	1	18094	48	GRM7
2.363e-02	-3.75	intracellularly cAMP-activated cation channel activity	molecular function	GO:0005222	9	1	18094	48	HCN1
2.363e-02	-3.75	G protein-coupled glutamate receptor activity	molecular function	GO:0098988	9	1	18094	48	GRM7
2.363e-02	-3.75	arrestin family protein binding	molecular function	GO:1990763	9	1	18094	48	CHRM2
2.373e-02	-3.74	Signaling by GPCR	REACTOME pathways	R-HSA-372790	1299	8	10285	29	GRIN1,GRM7,DLG4,CHRM2,NRG3,GABBR2,GRIN2B,PDE2A
2.376e-02	-3.74	clathrin-coated endocytic vesicle	cellular component	GO:0045334	93	2	19108	49	SYT1,CHRM2
2.391e-02	-3.73	SCN4A (sodium voltage-gated channel alpha subunit 4)	protein interactions	6329	95	2	19454	49	SCN8A,DLG3
2.394e-02	-3.73	bone-ilium-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-ilium-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	84	2	16828	48	CADPS,TENM1
2.404e-02	-3.73	ENaC	interpro domains	IPR001873	9	1	18521	50	ASIC2
2.404e-02	-3.73	Peptidase_S9	interpro domains	IPR001375	9	1	18521	50	DPP10
2.404e-02	-3.73	Quino_amine_DH_bsu	interpro domains	IPR011044	9	1	18521	50	OLFM1
2.405e-02	-3.73	Complement Module, domain 1	gene3d domains	2.10.70.10	74	2	14470	47	CSMD1,CSMD2
2.417e-02	-3.72	positive regulation of developmental process	biological process	GO:0051094	1385	8	18204	47	OLFM1,RIMS2,ASIC2,DLG4,SYT1,NRXN1,GRID2,ALK
2.452e-02	-3.71	ASC	pfam domains	PF00858	9	1	17795	49	ASIC2
2.452e-02	-3.71	Peptidase_S9	pfam domains	PF00326	9	1	17795	49	DPP10
2.457e-02	-3.71	cell development	biological process	GO:0048468	2236	11	18204	47	NRXN1,ALK,KCNIP2,HCN1,DLG4,CNTN5,CELF4,TENM1,PDE2A,GRM7,GABRB2
2.476e-02	-3.70	regulation of transferase activity	biological process	GO:0051338	645	5	18204	47	DLG4,DLG3,ALK,NTRK3,TENM1
2.486e-02	-3.69	LIN7C (lin-7 homolog C, crumbs cell polarity complex component)	protein interactions	55327	97	2	19454	49	DLG4,NTRK3
2.486e-02	-3.69	CCDC115 (coiled-coil domain containing 115)	protein interactions	84317	97	2	19454	49	NTRK3,ALK
2.486e-02	-3.69	Synaptic vesicle cycle	KEGG pathways	ko04721	63	2	7161	28	SYT1,CACNA1A
2.486e-02	-3.69	Synaptic vesicle cycle	KEGG pathways	hsa04721	63	2	7161	28	CACNA1A,SYT1
2.491e-02	-3.69	SLC35A3 (solute carrier family 35 member A3)	protein interactions	23443	10	1	19454	49	PDE2A
2.510e-02	-3.68	Ca2+ activated K+ channels	REACTOME pathways	R-HSA-1296052	9	1	10285	29	KCNMA1
2.518e-02	-3.68	oesophagus	COSMIC cancer mutations	oesophagus	14970	47	16828	48	GRIA3,GRIN1,GRIK2,CELF4,FAM131A,RIMS2,OLFM1,NRXN1,NRXN2,GABBR2,GABRD,GPR85,CACNA1G,KCNMA1,CSMD2,CACNA1A,GRM7,MCTP1,GABRA1,CADPS,TENM1,SCN8A,PDE2A,ALK,KCTD16,RALYL,DLG4,CELF2,CACNA1H,KCNIP2,SYT7,DLG3,DPP10,CELF5,FGF12,CNTN5,GABRB2,CHRM2,KCNT1,NTRK3,GRID2,SYT1,GRIN2B,STXBP5,KCNC1,NRG3,HCN1
2.531e-02	-3.68	uveal_tract	COSMIC cancer mutations	uveal_tract	587	5	16828	48	NTRK3,ALK,CSMD2,KCNMA1,GRIN2B
2.534e-02	-3.68	MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5)	protein interactions	11183	98	2	19454	49	NTRK3,ALK
2.534e-02	-3.68	MB21D2 (Mab-21 domain containing 2)	protein interactions	151963	98	2	19454	49	NTRK3,ALK
2.534e-02	-3.68	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	2	19454	49	NTRK3,ALK
2.534e-02	-3.68	PTK2B (protein tyrosine kinase 2 beta)	protein interactions	2185	98	2	19454	49	DLG4,DLG3
2.534e-02	-3.68	Nateglinide Action Pathway	SMPDB pathways	SMP0000453	5	1	1369	7	CACNA1A
2.534e-02	-3.68	Glibenclamide Action Pathway	SMPDB pathways	SMP0000460	5	1	1369	7	CACNA1A
2.534e-02	-3.68	Pancreas Function	SMPDB pathways	SMP0000643	5	1	1369	7	CACNA1A
2.534e-02	-3.68	Repaglinide Action Pathway	SMPDB pathways	SMP0000454	5	1	1369	7	CACNA1A
2.534e-02	-3.68	Gliclazide Action Pathway	SMPDB pathways	SMP0000461	5	1	1369	7	CACNA1A
2.536e-02	-3.67	cholinergic synapse	cellular component	GO:0098981	10	1	19108	49	CHRM2
2.543e-02	-3.67	cellular response to endogenous stimulus	biological process	GO:0071495	1135	7	18204	47	GABRB2,CACNA1H,GRIN1,HCN1,CACNA1A,NTRK3,PDE2A
2.543e-02	-3.67	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-essential_thrombocythaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-essential_thrombocythaemia	393	4	16828	48	CELF4,SYT7,CELF5,GRIN2B
2.543e-02	-3.67	essential_thrombocythaemia	COSMIC cancer mutations	essential_thrombocythaemia	393	4	16828	48	SYT7,CELF4,CELF5,GRIN2B
2.553e-02	-3.67	inhibitory postsynaptic potential	biological process	GO:0060080	10	1	18204	47	GRIK2
2.553e-02	-3.67	aldehyde biosynthetic process	biological process	GO:0046184	10	1	18204	47	CACNA1H
2.553e-02	-3.67	response to histamine	biological process	GO:0034776	10	1	18204	47	GABRB2
2.553e-02	-3.67	regulation of atrial cardiac muscle cell membrane depolarization	biological process	GO:0060371	10	1	18204	47	CACNA1G
2.553e-02	-3.67	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	47	NRG3
2.553e-02	-3.67	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	47	NRG3
2.553e-02	-3.67	regulation of voltage-gated sodium channel activity	biological process	GO:1905150	10	1	18204	47	FGF12
2.555e-02	-3.67	regulation of cell morphogenesis	biological process	GO:0022604	246	3	18204	47	RIMS2,SYT1,DLG4
2.566e-02	-3.66	GAF	smart domains	SM00065	7	1	9717	36	PDE2A
2.566e-02	-3.66	Ca_chan_IQ	smart domains	SM01062	7	1	9717	36	CACNA1A
2.570e-02	-3.66	-	gene3d domains	3.30.450.40	8	1	14470	47	PDE2A
2.579e-02	-3.66	response to endogenous stimulus	biological process	GO:0009719	1402	8	18204	47	NTRK3,CACNA1A,KCNC1,PDE2A,CACNA1H,GABRB2,HCN1,GRIN1
2.582e-02	-3.66	KCTD12 (potassium channel tetramerization domain containing 12)	protein interactions	115207	99	2	19454	49	GABBR2,KCTD16
2.622e-02	-3.64	neurotrophin binding	molecular function	GO:0043121	10	1	18094	48	NTRK3
2.628e-02	-3.64	G_PROTEIN_RECEP_F3_1	prosite domains	PS00979	9	1	12186	36	GRM7
2.630e-02	-3.64	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	49	DLG4,NRXN1
2.646e-02	-3.63	human chr3p26.1	chromosome location	human chr3p26.1	14	1	26134	50	GRM7
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.646e-02	-3.63	human chr3p14.2	chromosome location	human chr3p14.2	14	1	26134	50	CADPS
2.665e-02	-3.62	ilium	COSMIC cancer mutations	ilium	89	2	16828	48	CADPS,TENM1
2.668e-02	-3.62	Na_channel_asu	interpro domains	IPR001696	10	1	18521	50	SCN8A
2.668e-02	-3.62	Na_trans_assoc_dom	interpro domains	IPR010526	10	1	18521	50	SCN8A
2.668e-02	-3.62	FYVE_2	interpro domains	IPR041282	10	1	18521	50	RIMS2
2.668e-02	-3.62	Na_chnl_inactivation_gate	interpro domains	IPR044564	10	1	18521	50	SCN8A
2.691e-02	-3.62	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	biological process	GO:0000377	251	3	18204	47	CELF5,CELF2,CELF4
2.691e-02	-3.62	mRNA splicing, via spliceosome	biological process	GO:0000398	251	3	18204	47	CELF4,CELF2,CELF5
2.693e-02	-3.61	Platelet homeostasis	REACTOME pathways	R-HSA-418346	91	2	10285	29	KCNMA1,PDE2A
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	ALK,NTRK3
2.720e-02	-3.60	Na_trans_assoc	pfam domains	PF06512	10	1	17795	49	SCN8A
2.720e-02	-3.60	FYVE_2	pfam domains	PF02318	10	1	17795	49	RIMS2
2.728e-02	-3.60	PATJ (PATJ crumbs cell polarity complex component)	protein interactions	10207	102	2	19454	49	NRXN2,GRIN2B
2.737e-02	-3.60	RIMS3 (regulating synaptic membrane exocytosis 3)	protein interactions	9783	11	1	19454	49	RIMS2
2.737e-02	-3.60	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	49	NRXN1
2.737e-02	-3.60	SPATS1 (spermatogenesis associated serine rich 1)	protein interactions	221409	11	1	19454	49	GPHN
2.737e-02	-3.60	GRIP2 (glutamate receptor interacting protein 2)	protein interactions	80852	11	1	19454	49	GRIA3
2.737e-02	-3.60	CELF3 (CUGBP Elav-like family member 3)	protein interactions	11189	11	1	19454	49	CELF5
2.737e-02	-3.60	SV2C (synaptic vesicle glycoprotein 2C)	protein interactions	22987	11	1	19454	49	SYT1
2.746e-02	-3.60	regulation of transporter activity	biological process	GO:0032409	253	3	18204	47	FGF12,DLG4,KCNIP2
2.778e-02	-3.58	ARFGAP3 (ADP ribosylation factor GTPase activating protein 3)	protein interactions	26286	103	2	19454	49	NTRK3,ALK
2.778e-02	-3.58	PLEKHA1 (pleckstrin homology domain containing A1)	protein interactions	59338	103	2	19454	49	ALK,NTRK3
2.785e-02	-3.58	Neurotoxicity of clostridium toxins	REACTOME pathways	R-HSA-168799	10	1	10285	29	SYT1
2.785e-02	-3.58	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	29	NRG3
2.786e-02	-3.58	symmetric synapse	cellular component	GO:0032280	11	1	19108	49	CHRM2
2.786e-02	-3.58	presynaptic cytoskeleton	cellular component	GO:0099569	11	1	19108	49	RIMS2
2.786e-02	-3.58	G protein-coupled receptor complex	cellular component	GO:0097648	11	1	19108	49	GABBR2
2.788e-02	-3.58	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	28	GRIN2B,GRIN1
2.788e-02	-3.58	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	28	GRIN2B,GRIN1
2.794e-02	-3.58	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	47	TENM1,GRIN2B,GRID2,NTRK3,ALK
2.800e-02	-3.58	Effects of Botulinum toxin	Pathway Interaction DB	botulinumtoxinpathway	9	1	2226	7	SYT1
2.801e-02	-3.58	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	48	PDE2A,ALK,DPP10,KCNMA1,GABBR2
2.802e-02	-3.57	RNA splicing, via transesterification reactions	biological process	GO:0000375	255	3	18204	47	CELF5,CELF2,CELF4
2.804e-02	-3.57	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	47	NRG3
2.804e-02	-3.57	positive regulation of acrosome reaction	biological process	GO:2000344	11	1	18204	47	CACNA1H
2.804e-02	-3.57	olefinic compound biosynthetic process	biological process	GO:0120255	11	1	18204	47	CACNA1H
2.804e-02	-3.57	retinal cone cell development	biological process	GO:0046549	11	1	18204	47	HCN1
2.804e-02	-3.57	ectodermal placode formation	biological process	GO:0060788	11	1	18204	47	NRG3
2.804e-02	-3.57	regulation of cGMP-mediated signaling	biological process	GO:0010752	11	1	18204	47	PDE2A
2.804e-02	-3.57	regulation of dopamine receptor signaling pathway	biological process	GO:0060159	11	1	18204	47	ALK
2.804e-02	-3.57	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	47	NRG3
2.804e-02	-3.57	positive regulation of voltage-gated potassium channel activity	biological process	GO:1903818	11	1	18204	47	KCNIP2
2.804e-02	-3.57	negative regulation of excitatory postsynaptic potential	biological process	GO:0090394	11	1	18204	47	CELF4
2.832e-02	-3.56	human chr12q21.2	chromosome location	human chr12q21.2	15	1	26134	50	SYT1
2.838e-02	-3.56	MUSCARINICR	prints domains	PR00243	5	1	5227	30	CHRM2
2.847e-02	-3.56	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	47	ALK,NTRK3,NRG3,GRID2,GRIN2B,GRIA3,GRIN1,GRIK2,GRM7,CELF4
2.853e-02	-3.56	eye	COSMIC cancer mutations	eye	606	5	16828	48	NTRK3,ALK,CSMD2,KCNMA1,GRIN2B
2.861e-02	-3.55	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	9	16828	48	TENM1,HCN1,FGF12,GRM7,ALK,MCTP1,GABBR2,NRG3,GRID2
2.878e-02	-3.55	EPS8 (EGFR pathway substrate 8, signaling adaptor)	protein interactions	2059	105	2	19454	49	NTRK3,PDE2A
2.880e-02	-3.55	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	molecular function	GO:0005221	11	1	18094	48	HCN1
2.880e-02	-3.55	cyclic nucleotide-activated monoatomic ion channel activity	molecular function	GO:0043855	11	1	18094	48	HCN1
2.880e-02	-3.55	benzodiazepine receptor activity	molecular function	GO:0008503	11	1	18094	48	GABRA1
2.880e-02	-3.55	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0099508	11	1	18094	48	KCNC1
2.886e-02	-3.55	-	gene3d domains	1.10.357.50	9	1	14470	47	CADPS
2.891e-02	-3.54	ductal_carcinoma_in_situ	COSMIC cancer mutations	ductal_carcinoma_in_situ	93	2	16828	48	NTRK3,ALK
2.891e-02	-3.54	carcinoma_in_situ	COSMIC cancer mutations	carcinoma_in_situ	93	2	16828	48	NTRK3,ALK
2.891e-02	-3.54	breast-carcinoma_in_situ-ductal_carcinoma_in_situ	COSMIC cancer mutations	breast-carcinoma_in_situ-ductal_carcinoma_in_situ	93	2	16828	48	ALK,NTRK3
2.905e-02	-3.54	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	41	16828	48	DPP10,SYT7,KCNIP2,GABBR2,NRXN1,NRXN2,CHRM2,GABRB2,CNTN5,FGF12,KCNMA1,CACNA1G,CELF5,RALYL,GRIK2,GRIN1,CELF4,KCTD16,GRIA3,OLFM1,CACNA1H,RIMS2,GABRA1,NRG3,CADPS,MCTP1,KCNC1,ALK,PDE2A,HCN1,SCN8A,TENM1,GRID2,NTRK3,KCNT1,GRM7,STXBP5,CACNA1A,SYT1,GRIN2B,CSMD2
2.905e-02	-3.54	cerebellum development	biological process	GO:0021549	103	2	18204	47	GRID2,KCNC1
2.916e-02	-3.54	EPH-Ephrin signaling	REACTOME pathways	R-HSA-2682334	95	2	10285	29	GRIN1,GRIN2B
2.940e-02	-3.53	response to organonitrogen compound	biological process	GO:0010243	915	6	18204	47	PDE2A,KCNC1,CACNA1A,GRIN1,HCN1,GABRB2
2.958e-02	-3.52	breast-carcinoma	COSMIC cancer mutations	breast-carcinoma	15030	47	16828	48	NRG3,KCNC1,HCN1,NTRK3,GRID2,KCNT1,STXBP5,GRIN2B,SYT1,DLG3,SYT7,DPP10,KCNIP2,GABRB2,CHRM2,CELF5,CNTN5,FGF12,RALYL,DLG4,KCTD16,CELF2,CACNA1H,CADPS,GABRA1,MCTP1,PDE2A,ALK,TENM1,SCN8A,GRM7,CSMD2,CACNA1A,NRXN1,NRXN2,GABBR2,GABRD,CACNA1G,GPR85,KCNMA1,CELF4,GRIN1,GRIK2,FAM131A,GRIA3,OLFM1,RIMS2
2.979e-02	-3.51	myelofibrosis	COSMIC cancer mutations	myelofibrosis	413	4	16828	48	CNTN5,RIMS2,GRIN2B,ALK
2.979e-02	-3.51	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosis	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosis	413	4	16828	48	ALK,CNTN5,RIMS2,GRIN2B
2.980e-02	-3.51	APLP2 (amyloid beta precursor like protein 2)	protein interactions	334	107	2	19454	49	GRIN2B,GRIN1
2.982e-02	-3.51	NPY4R (neuropeptide Y receptor Y4)	protein interactions	5540	12	1	19454	49	ALK
2.982e-02	-3.51	TIGD3 (tigger transposable element derived 3)	protein interactions	220359	12	1	19454	49	RALYL
2.982e-02	-3.51	SHISA4 (shisa family member 4)	protein interactions	149345	12	1	19454	49	CHRM2
2.982e-02	-3.51	SLC52A2 (solute carrier family 52 member 2)	protein interactions	79581	12	1	19454	49	CHRM2
2.982e-02	-3.51	CACNA1S (calcium voltage-gated channel subunit alpha1 S)	protein interactions	779	12	1	19454	49	RIMS2
2.996e-02	-3.51	G alpha (i) signalling events	REACTOME pathways	R-HSA-418594	242	3	10285	29	GRM7,GABBR2,CHRM2
3.000e-02	-3.51	modified amino acid binding	molecular function	GO:0072341	102	2	18094	48	SYT1,SYT7
3.010e-02	-3.50	gland morphogenesis	biological process	GO:0022612	105	2	18204	47	NRG3,CSMD1
3.010e-02	-3.50	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	47	GRID2,GRIN2B
3.019e-02	-3.50	EGF	smart domains	SM00181	184	3	9717	36	NRXN1,TENM1,NRXN2
3.031e-02	-3.50	DRD2 (dopamine receptor D2)	protein interactions	1813	108	2	19454	49	GABBR2,CADPS
3.035e-02	-3.49	clathrin-sculpted vesicle	cellular component	GO:0060198	12	1	19108	49	SYT1
3.035e-02	-3.49	juxtaparanode region of axon	cellular component	GO:0044224	12	1	19108	49	DLG4
3.036e-02	-3.49	G protein-coupled receptor signaling pathway	biological process	GO:0007186	1178	7	18204	47	GPR85,TENM1,PDE2A,GRM7,RIMS2,CHRM2,GABBR2
3.056e-02	-3.49	regulation of synaptic vesicle membrane organization	biological process	GO:1901632	12	1	18204	47	SYT1
3.056e-02	-3.49	regulation of synaptic vesicle fusion to presynaptic active zone membrane	biological process	GO:0031630	12	1	18204	47	SYT1
3.056e-02	-3.49	positive regulation of catecholamine secretion	biological process	GO:0033605	12	1	18204	47	SYT1
3.056e-02	-3.49	negative regulation of response to oxidative stress	biological process	GO:1902883	12	1	18204	47	MCTP1
3.056e-02	-3.49	sinoatrial node development	biological process	GO:0003163	12	1	18204	47	CACNA1G
3.056e-02	-3.49	AV node cell to bundle of His cell communication	biological process	GO:0086067	12	1	18204	47	CACNA1G
3.056e-02	-3.49	neuronal ion channel clustering	biological process	GO:0045161	12	1	18204	47	KCNIP2
3.056e-02	-3.49	response to macrophage colony-stimulating factor	biological process	GO:0036005	12	1	18204	47	PDE2A
3.083e-02	-3.48	NOS1AP (nitric oxide synthase 1 adaptor protein)	protein interactions	9722	109	2	19454	49	FGF12,NTRK3
3.094e-02	-3.48	tubular_adenocarcinoma	COSMIC cancer mutations	tubular_adenocarcinoma	11	1	16828	48	NTRK3
3.094e-02	-3.48	stomach-carcinoma-tubular_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-tubular_adenocarcinoma	11	1	16828	48	NTRK3
3.124e-02	-3.47	myxoid-round_cell	COSMIC cancer mutations	myxoid-round_cell	97	2	16828	48	GRIK2,HCN1
3.124e-02	-3.47	soft_tissue-fat-liposarcoma-myxoid-round_cell	COSMIC cancer mutations	soft_tissue-fat-liposarcoma-myxoid-round_cell	97	2	16828	48	GRIK2,HCN1
3.129e-02	-3.46	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	36	NTRK3,ALK
3.137e-02	-3.46	import into cell	biological process	GO:0098657	687	5	18204	47	CACNA1G,CACNA1A,SYT7,CACNA1H,SYT1
3.138e-02	-3.46	dipeptidyl-peptidase activity	molecular function	GO:0008239	12	1	18094	48	DPP10
3.138e-02	-3.46	G protein-coupled neurotransmitter receptor activity	molecular function	GO:0099528	12	1	18094	48	CHRM2
3.138e-02	-3.46	phosphate ion binding	molecular function	GO:0042301	12	1	18094	48	PDE2A
3.146e-02	-3.46	Cargo recognition for clathrin-mediated endocytosis	REACTOME pathways	R-HSA-8856825	99	2	10285	29	SYT1,CHRM2
3.186e-02	-3.45	cortical cytoskeleton	cellular component	GO:0030863	109	2	19108	49	RIMS2,DLG4
3.193e-02	-3.44	Rab_BD	interpro domains	IPR010911	12	1	18521	50	RIMS2
3.193e-02	-3.44	V_SNARE_CC	interpro domains	IPR042855	12	1	18521	50	STXBP5
3.193e-02	-3.44	K_chnl_volt-dep_EAG/ELK/ERG	interpro domains	IPR003938	12	1	18521	50	HCN1
3.202e-02	-3.44	Helix hairpin bin	gene3d domains	1.10.287.630	10	1	14470	47	HCN1
3.210e-02	-3.44	positive regulation of molecular function	biological process	GO:0044093	1192	7	18204	47	DLG4,GRIN2B,NTRK3,ALK,KCNIP2,TENM1,DLG3
3.224e-02	-3.43	LGALS3BP (galectin 3 binding protein)	protein interactions	3959	276	3	19454	49	GPHN,GABRA1,NTRK3
3.226e-02	-3.43	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	49	RIMS2
3.226e-02	-3.43	ZFP69B (ZFP69 zinc finger protein B)	protein interactions	65243	13	1	19454	49	KCTD16
3.226e-02	-3.43	ZNF79 (zinc finger protein 79)	protein interactions	7633	13	1	19454	49	FGF12
3.226e-02	-3.43	CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4)	protein interactions	785	13	1	19454	49	CACNA1A
3.226e-02	-3.43	CABP1 (calcium binding protein 1)	protein interactions	9478	13	1	19454	49	CACNA1A
3.226e-02	-3.43	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	49	NRXN1
3.226e-02	-3.43	PPM1L (protein phosphatase, Mg2+/Mn2+ dependent 1L)	protein interactions	151742	13	1	19454	49	PDE2A
3.226e-02	-3.43	IGLC6 (immunoglobulin lambda constant 6)	protein interactions	3542	13	1	19454	49	HCN1
3.241e-02	-3.43	GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3)	protein interactions	23163	112	2	19454	49	NTRK3,ALK
3.241e-02	-3.43	CAV2 (caveolin 2)	protein interactions	858	112	2	19454	49	PDE2A,KCNMA1
3.247e-02	-3.43	regulation of protein kinase activity	biological process	GO:0045859	469	4	18204	47	DLG4,DLG3,NTRK3,TENM1
3.284e-02	-3.42	early phagosome	cellular component	GO:0032009	13	1	19108	49	SYT7
3.306e-02	-3.41	prepulse inhibition	biological process	GO:0060134	13	1	18204	47	GRID2
3.306e-02	-3.41	ectodermal placode development	biological process	GO:0071696	13	1	18204	47	NRG3
3.306e-02	-3.41	phagosome-lysosome fusion	biological process	GO:0090385	13	1	18204	47	SYT7
3.306e-02	-3.41	regulation of postsynaptic density assembly	biological process	GO:0099151	13	1	18204	47	GRID2
3.306e-02	-3.41	cerebellar granular layer development	biological process	GO:0021681	13	1	18204	47	GRID2
3.306e-02	-3.41	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	47	GRIN2B
3.306e-02	-3.41	positive regulation of calcium ion transport into cytosol	biological process	GO:0010524	13	1	18204	47	GRIN1
3.306e-02	-3.41	retinal cone cell differentiation	biological process	GO:0042670	13	1	18204	47	HCN1
3.306e-02	-3.41	nervous system process involved in regulation of systemic arterial blood pressure	biological process	GO:0001976	13	1	18204	47	ASIC2
3.309e-02	-3.41	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	5	18204	47	DLG4,TENM1,ALK,DLG3,NTRK3
3.309e-02	-3.41	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	5	18204	47	DLG3,ALK,NTRK3,TENM1,DLG4
3.332e-02	-3.40	phosphatidylinositol bisphosphate binding	molecular function	GO:1902936	108	2	18094	48	SYT1,SYT7
3.333e-02	-3.40	vascular process in circulatory system	biological process	GO:0003018	273	3	18204	47	KCNMA1,ASIC2,PDE2A
3.347e-02	-3.40	HS2ST1 (heparan sulfate 2-O-sulfotransferase 1)	protein interactions	9653	114	2	19454	49	ASIC2,PDE2A
3.364e-02	-3.39	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	3	16828	48	NRG3,SYT1,GABBR2
3.364e-02	-3.39	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	3	16828	48	GABBR2,SYT1,NRG3
3.364e-02	-3.39	temporal_lobe	COSMIC cancer mutations	temporal_lobe	101	2	16828	48	ALK,FGF12
3.371e-02	-3.39	left	COSMIC cancer mutations	left	12	1	16828	48	ALK
3.395e-02	-3.38	oxidoreductase activity, acting on other nitrogenous compounds as donors	molecular function	GO:0016661	13	1	18094	48	GPHN
3.395e-02	-3.38	calcium-activated potassium channel activity	molecular function	GO:0015269	13	1	18094	48	KCNMA1
3.395e-02	-3.38	myosin II binding	molecular function	GO:0045159	13	1	18094	48	STXBP5
3.396e-02	-3.38	GABAARALPHA	prints domains	PR01079	6	1	5227	30	GABRA1
3.426e-02	-3.37	telencephalon development	biological process	GO:0021537	276	3	18204	47	ALK,KCNC1,NRG3
3.438e-02	-3.37	Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME pathways	R-HSA-881907	443	4	10285	29	GRIN1,NRG3,GRIN2B,DLG4
3.444e-02	-3.37	metencephalon development	biological process	GO:0022037	113	2	18204	47	GRID2,KCNC1
3.447e-02	-3.37	SH3_1	pfam domains	PF00018	106	2	17795	49	DLG4,DLG3
3.454e-02	-3.37	GPCR_3_9-Cys_sf	interpro domains	IPR038550	13	1	18521	50	GRM7
3.454e-02	-3.37	Olfac-like_dom	interpro domains	IPR003112	13	1	18521	50	OLFM1
3.454e-02	-3.37	GPCR_3_9-Cys_dom	interpro domains	IPR011500	13	1	18521	50	GRM7
3.465e-02	-3.36	NEDD4L (NEDD4 like E3 ubiquitin protein ligase)	protein interactions	23327	284	3	19454	49	DLG3,FGF12,HCN1
3.466e-02	-3.36	cGMP signaling	KEGG pathways	hsa_M00694	9	1	7161	28	PDE2A
3.466e-02	-3.36	cGMP signaling	KEGG pathways	M00694	9	1	7161	28	PDE2A
3.470e-02	-3.36	KCNC1 (potassium voltage-gated channel subfamily C member 1)	protein interactions	3746	14	1	19454	49	KCNC1
3.470e-02	-3.36	CIMAP1D (CIMAP1 family member D)	protein interactions	284451	14	1	19454	49	GPHN
3.470e-02	-3.36	CHGA (chromogranin A)	protein interactions	1113	14	1	19454	49	SYT1
3.470e-02	-3.36	GRID2 (glutamate ionotropic receptor delta type subunit 2)	protein interactions	2895	14	1	19454	49	GRIK2
3.470e-02	-3.36	ABTB1 (ankyrin repeat and BTB domain containing 1)	protein interactions	80325	14	1	19454	49	NTRK3
3.470e-02	-3.36	RNF121 (ring finger protein 121)	protein interactions	55298	14	1	19454	49	PDE2A
3.470e-02	-3.36	KCNIP2 (potassium voltage-gated channel interacting protein 2)	protein interactions	30819	14	1	19454	49	KCNIP2
3.490e-02	-3.36	V_SNARE	prosite domains	PS50892	12	1	12186	36	STXBP5
3.490e-02	-3.36	RABBD	prosite domains	PS50916	12	1	12186	36	RIMS2
3.520e-02	-3.35	TyrKc	smart domains	SM00219	80	2	9717	36	ALK,NTRK3
3.522e-02	-3.35	NCD3G	pfam domains	PF07562	13	1	17795	49	GRM7
3.522e-02	-3.35	OLF	pfam domains	PF02191	13	1	17795	49	OLFM1
3.527e-02	-3.34	SERPINH1 (serpin family H member 1)	protein interactions	871	286	3	19454	49	ALK,GABRA1,NTRK3
3.532e-02	-3.34	chromaffin granule	cellular component	GO:0042583	14	1	19108	49	SYT1
3.532e-02	-3.34	voltage-gated sodium channel complex	cellular component	GO:0001518	14	1	19108	49	SCN8A
3.556e-02	-3.34	peptidyl-tyrosine autophosphorylation	biological process	GO:0038083	14	1	18204	47	ALK
3.556e-02	-3.34	G protein-coupled glutamate receptor signaling pathway	biological process	GO:0007216	14	1	18204	47	GRM7
3.556e-02	-3.34	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	GO:0106072	14	1	18204	47	PDE2A
3.556e-02	-3.34	neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0099645	14	1	18204	47	DLG4
3.556e-02	-3.34	cyclic nucleotide catabolic process	biological process	GO:0009214	14	1	18204	47	PDE2A
3.556e-02	-3.34	negative regulation of adenylate cyclase activity	biological process	GO:0007194	14	1	18204	47	GABBR2
3.556e-02	-3.34	response to light intensity	biological process	GO:0009642	14	1	18204	47	KCNC1
3.556e-02	-3.34	protein localization to postsynaptic specialization membrane	biological process	GO:0099633	14	1	18204	47	DLG4
3.556e-02	-3.34	regulation of long-term synaptic depression	biological process	GO:1900452	14	1	18204	47	GRID2
3.556e-02	-3.34	regulation of NMDA receptor activity	biological process	GO:2000310	14	1	18204	47	DLG4
3.556e-02	-3.34	Huntington's disease	KEGG pathways	ko05016	187	3	7161	28	GRIN1,GRIN2B,DLG4
3.556e-02	-3.34	Huntington's disease	KEGG pathways	hsa05016	187	3	7161	28	GRIN1,GRIN2B,DLG4
3.561e-02	-3.34	protein-containing complex organization	biological process	GO:0043933	2067	10	18204	47	SYT1,HCN1,DLG4,CELF5,GRIN2B,KCNC1,GRIN1,CELF4,CELF2,KCTD16
3.574e-02	-3.33	human chr15q25.3	chromosome location	human chr15q25.3	19	1	26134	50	NTRK3
3.606e-02	-3.32	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	29	NRG3
3.606e-02	-3.32	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	REACTOME pathways	R-HSA-112308	13	1	10285	29	CACNA1A
3.612e-02	-3.32	regulation of cation channel activity	biological process	GO:2001257	116	2	18204	47	FGF12,KCNIP2
3.620e-02	-3.32	THAP1 (THAP domain containing 1)	protein interactions	55145	119	2	19454	49	FGF12,RALYL
3.647e-02	-3.31	mucinous_adenocarcinoma	COSMIC cancer mutations	mucinous_adenocarcinoma	13	1	16828	48	NTRK3
3.647e-02	-3.31	stomach-carcinoma-mucinous_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-mucinous_adenocarcinoma	13	1	16828	48	NTRK3
3.647e-02	-3.31	autonomic_ganglia-adrenal_gland-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-adrenal_gland-paraganglioma-benign	13	1	16828	48	PDE2A
3.652e-02	-3.31	mRNA regulatory element binding translation repressor activity	molecular function	GO:0000900	14	1	18094	48	CELF4
3.652e-02	-3.31	dopamine receptor binding	molecular function	GO:0050780	14	1	18094	48	DLG4
3.656e-02	-3.31	pulmonary_blastoma	COSMIC cancer mutations	pulmonary_blastoma	648	5	16828	48	SYT7,PDE2A,ALK,RIMS2,CACNA1A
3.656e-02	-3.31	pleura-pulmonary_blastoma	COSMIC cancer mutations	pleura-pulmonary_blastoma	648	5	16828	48	ALK,SYT7,PDE2A,CACNA1A,RIMS2
3.676e-02	-3.30	TMEM201 (transmembrane protein 201)	protein interactions	199953	120	2	19454	49	GABRD,ALK
3.683e-02	-3.30	GOPC (golgi associated PDZ and coiled-coil motif containing)	protein interactions	57120	291	3	19454	49	GRID2,NTRK3,ALK
3.714e-02	-3.29	ADGRB2 (adhesion G protein-coupled receptor B2)	protein interactions	576	15	1	19454	49	DLG4
3.714e-02	-3.29	MEGF6 (multiple EGF like domains 6)	protein interactions	1953	15	1	19454	49	CACNA1A
3.714e-02	-3.29	TC2N (tandem C2 domains, nuclear)	protein interactions	123036	15	1	19454	49	CADPS
3.714e-02	-3.29	FZD1 (frizzled class receptor 1)	protein interactions	8321	15	1	19454	49	DLG4
3.714e-02	-3.29	CCDC127 (coiled-coil domain containing 127)	protein interactions	133957	15	1	19454	49	PDE2A
3.714e-02	-3.29	GPR88 (G protein-coupled receptor 88)	protein interactions	54112	15	1	19454	49	GRIN1
3.714e-02	-3.29	MEP1B (meprin A subunit beta)	protein interactions	4225	15	1	19454	49	ALK
3.714e-02	-3.29	PRR16 (proline rich 16)	protein interactions	51334	15	1	19454	49	DLG4
3.714e-02	-3.29	RGS9 (regulator of G protein signaling 9)	protein interactions	8787	15	1	19454	49	GRIN1
3.714e-02	-3.29	CACNA1H (calcium voltage-gated channel subunit alpha1 H)	protein interactions	8912	15	1	19454	49	KCNMA1
3.715e-02	-3.29	Recoverin	interpro domains	IPR028846	14	1	18521	50	KCNIP2
3.754e-02	-3.28	positive regulation of cell communication	biological process	GO:0010647	1792	9	18204	47	NTRK3,NRXN1,GRIN2B,SYT1,DLG4,RIMS2,TENM1,GRIN1,GRIK2
3.759e-02	-3.28	human chr18q12.2	chromosome location	human chr18q12.2	20	1	26134	50	CELF4
3.759e-02	-3.28	human chr12p13.1	chromosome location	human chr12p13.1	20	1	26134	50	GRIN2B
3.775e-02	-3.28	OLF	prosite domains	PS51132	13	1	12186	36	OLFM1
3.775e-02	-3.28	G_PROTEIN_RECEP_F3_2	prosite domains	PS00980	13	1	12186	36	GRM7
3.777e-02	-3.28	positive regulation of signaling	biological process	GO:0023056	1794	9	18204	47	SYT1,DLG4,NTRK3,NRXN1,GRIN2B,GRIK2,GRIN1,RIMS2,TENM1
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	KCNC1
3.805e-02	-3.27	cellular response to acidic pH	biological process	GO:0071468	15	1	18204	47	ASIC2
3.805e-02	-3.27	tertiary alcohol metabolic process	biological process	GO:1902644	15	1	18204	47	CACNA1H
3.805e-02	-3.27	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	47	KCNMA1
3.805e-02	-3.27	potassium ion export across plasma membrane	biological process	GO:0097623	15	1	18204	47	KCNIP2
3.805e-02	-3.27	negative regulation of amino acid transport	biological process	GO:0051956	15	1	18204	47	GRM7
3.805e-02	-3.27	negative regulation of cyclase activity	biological process	GO:0031280	15	1	18204	47	GABBR2
3.805e-02	-3.27	dense core granule localization	biological process	GO:0032253	15	1	18204	47	CADPS
3.805e-02	-3.27	heart valve formation	biological process	GO:0003188	15	1	18204	47	OLFM1
3.805e-02	-3.27	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	47	DLG4
3.805e-02	-3.27	glucocorticoid metabolic process	biological process	GO:0008211	15	1	18204	47	CACNA1H
3.805e-02	-3.27	apical protein localization	biological process	GO:0045176	15	1	18204	47	HCN1
3.842e-02	-3.26	regulation of peptidyl-serine phosphorylation	biological process	GO:0033135	120	2	18204	47	TENM1,NTRK3
3.844e-02	-3.26	EXOC7 (exocyst complex component 7)	protein interactions	23265	123	2	19454	49	DLG3,GRIN2B
3.878e-02	-3.25	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	7	16828	48	NTRK3,CADPS,DLG3,GABRA1,GRIN2B,CSMD2,ALK
3.878e-02	-3.25	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	29	NRG3
3.901e-02	-3.24	TNK2 (tyrosine kinase non receptor 2)	protein interactions	10188	124	2	19454	49	NTRK3,ALK
3.908e-02	-3.24	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization	molecular function	GO:0086008	15	1	18094	48	KCNIP2
3.915e-02	-3.24	regulation of anatomical structure size	biological process	GO:0090066	498	4	18204	47	TENM1,OLFM1,ASIC2,KCNMA1
3.925e-02	-3.24	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	9	16828	48	SYT1,CSMD2,GRM7,PDE2A,GABRB2,GABBR2,GRIN1,CADPS,GRID2
3.930e-02	-3.24	mixed_adenosquamous_carcinoma	COSMIC cancer mutations	mixed_adenosquamous_carcinoma	110	2	16828	48	NTRK3,ALK
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.951e-02	-3.23	HUDSXLRNA	prints domains	PR00961	7	1	5227	30	CELF2
3.956e-02	-3.23	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	49	NRXN1
3.956e-02	-3.23	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	49	NRXN1
3.956e-02	-3.23	ZAR1L (zygote arrest 1 like)	protein interactions	646799	16	1	19454	49	GPHN
3.956e-02	-3.23	RBM18 (RNA binding motif protein 18)	protein interactions	92400	16	1	19454	49	SYT1
3.956e-02	-3.23	CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1)	protein interactions	782	16	1	19454	49	CACNA1A
3.956e-02	-3.23	GABBR2 (gamma-aminobutyric acid type B receptor subunit 2)	protein interactions	9568	16	1	19454	49	KCTD16
3.956e-02	-3.23	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	49	DLG4
3.956e-02	-3.23	KCNH1 (potassium voltage-gated channel subfamily H member 1)	protein interactions	3756	16	1	19454	49	KCNC1
3.956e-02	-3.23	WASH6P (WASP family homolog 6, pseudogene)	protein interactions	653440	16	1	19454	49	NTRK3
3.956e-02	-3.23	GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3)	protein interactions	2562	16	1	19454	49	GABRB2
3.956e-02	-3.23	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	49	DLG4
3.956e-02	-3.23	KLKB1 (kallikrein B1)	protein interactions	3818	16	1	19454	49	GPHN
3.956e-02	-3.23	KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)	protein interactions	3761	16	1	19454	49	DLG4
3.956e-02	-3.23	TTLL10 (tubulin tyrosine ligase like 10)	protein interactions	254173	16	1	19454	49	CADPS
3.973e-02	-3.23	benign	COSMIC cancer mutations	benign	265	3	16828	48	PDE2A,CACNA1H,CNTN5
3.995e-02	-3.22	liposarcoma	COSMIC cancer mutations	liposarcoma	111	2	16828	48	HCN1,GRIK2
4.000e-02	-3.22	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	6	16828	48	GABBR2,CACNA1A,ALK,STXBP5,CELF4,GRIN1
4.006e-02	-3.22	cellular response to chemical stimulus	biological process	GO:0070887	2411	11	18204	47	CHRM2,KCNC1,DLG4,HCN1,SYT1,PDE2A,ASIC2,CACNA1A,GRIN1,CACNA1H,GABRB2
4.016e-02	-3.21	NTPCR (nucleoside-triphosphatase, cancer-related)	protein interactions	84284	126	2	19454	49	NTRK3,ALK
4.022e-02	-3.21	ErbB receptor signaling network	Pathway Interaction DB	erbb_network_pathway	13	1	2226	7	NRG3
4.027e-02	-3.21	node of Ranvier	cellular component	GO:0033268	16	1	19108	49	SCN8A
4.036e-02	-3.21	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	48	16828	48	GRID2,NTRK3,KCNT1,STXBP5,SYT1,GRIN2B,GPHN,NRG3,KCNC1,HCN1,DLG4,RALYL,KCTD16,CELF2,CACNA1H,DPP10,DLG3,SYT7,KCNIP2,CHRM2,GABRB2,CNTN5,FGF12,CELF5,GRM7,CACNA1A,CSMD2,CADPS,GABRA1,MCTP1,ALK,PDE2A,SCN8A,TENM1,FAM131A,GRIN1,GRIK2,CELF4,GRIA3,OLFM1,RIMS2,GABBR2,NRXN1,NRXN2,CACNA1G,GPR85,KCNMA1,GABRD
4.048e-02	-3.21	regulation of endocytosis	biological process	GO:0030100	295	3	18204	47	SYT7,DLG4,MCTP1
4.054e-02	-3.21	regulation of postsynaptic specialization assembly	biological process	GO:0099150	16	1	18204	47	GRID2
4.054e-02	-3.21	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	47	DLG4
4.054e-02	-3.21	regulation of short-term neuronal synaptic plasticity	biological process	GO:0048172	16	1	18204	47	GRIK2
4.054e-02	-3.21	glutamatergic neuron differentiation	biological process	GO:1905962	16	1	18204	47	GRID2
4.054e-02	-3.21	positive regulation of dendrite development	biological process	GO:1900006	16	1	18204	47	ALK
4.054e-02	-3.21	regulation of transmission of nerve impulse	biological process	GO:0051969	16	1	18204	47	FGF12
4.074e-02	-3.20	TUBA3C (tubulin alpha 3c)	protein interactions	7278	127	2	19454	49	GRM7,OLFM1
4.082e-02	-3.20	positive regulation of nervous system development	biological process	GO:0051962	296	3	18204	47	GRID2,NRXN1,ASIC2
4.127e-02	-3.19	human chr5p12	chromosome location	human chr5p12	22	1	26134	50	HCN1
4.132e-02	-3.19	STIM2 (stromal interaction molecule 2)	protein interactions	57620	128	2	19454	49	NTRK3,ALK
4.132e-02	-3.19	SYT2 (synaptotagmin 2)	protein interactions	127833	128	2	19454	49	NRXN1,SYT1
4.137e-02	-3.19	mammary gland development	biological process	GO:0030879	125	2	18204	47	NRG3,CSMD1
4.138e-02	-3.18	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	7	16828	48	GRIN2B,CSMD2,ALK,CADPS,DLG3,GABRA1,NTRK3
4.143e-02	-3.18	GPCR, family 3, nine cysteines domain	gene3d domains	2.10.50.30	13	1	14470	47	GRM7
4.143e-02	-3.18	iswi atpase	gene3d domains	1.20.5.1190	13	1	14470	47	SCN8A
4.150e-02	-3.18	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	29	NRG3
4.150e-02	-3.18	LGI-ADAM interactions	REACTOME pathways	R-HSA-5682910	15	1	10285	29	DLG4
4.163e-02	-3.18	cyclase regulator activity	molecular function	GO:0010851	16	1	18094	48	GRM7
4.163e-02	-3.18	cGMP binding	molecular function	GO:0030553	16	1	18094	48	PDE2A
4.194e-02	-3.17	pancreas-pancreatic_intraepithelial_neoplasia_(PanIN)	COSMIC cancer mutations	pancreas-pancreatic_intraepithelial_neoplasia_(PanIN)	673	5	16828	48	CACNA1G,KCNMA1,GRIN2B,CSMD2,GRIK2
4.194e-02	-3.17	pancreatic_intraepithelial_neoplasia_(PanIN)	COSMIC cancer mutations	pancreatic_intraepithelial_neoplasia_(PanIN)	673	5	16828	48	KCNMA1,GRIN2B,CACNA1G,CSMD2,GRIK2
4.196e-02	-3.17	right	COSMIC cancer mutations	right	15	1	16828	48	ALK
4.197e-02	-3.17	response to ethanol	biological process	GO:0045471	126	2	18204	47	GRIN1,GRIN2B
4.198e-02	-3.17	IL13RA1 (interleukin 13 receptor subunit alpha 1)	protein interactions	3597	17	1	19454	49	DLG4
4.198e-02	-3.17	NEU3 (neuraminidase 3)	protein interactions	10825	17	1	19454	49	NTRK3
4.198e-02	-3.17	CYP20A1 (cytochrome P450 family 20 subfamily A member 1)	protein interactions	57404	17	1	19454	49	PDE2A
4.198e-02	-3.17	MFSD10 (major facilitator superfamily domain containing 10)	protein interactions	10227	17	1	19454	49	PDE2A
4.226e-02	-3.16	extraskeletal	COSMIC cancer mutations	extraskeletal	903	6	16828	48	STXBP5,ALK,CACNA1A,CELF4,GRIN1,GABBR2
4.235e-02	-3.16	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	50	HCN1
4.257e-02	-3.16	positive regulation of protein serine/threonine kinase activity	biological process	GO:0071902	127	2	18204	47	TENM1,NTRK3
4.273e-02	-3.15	acetylcholine-gated channel complex	cellular component	GO:0005892	17	1	19108	49	STXBP5
4.273e-02	-3.15	presynaptic active zone cytoplasmic component	cellular component	GO:0098831	17	1	19108	49	RIMS2
4.301e-02	-3.15	positive regulation of neurotransmitter secretion	biological process	GO:0001956	17	1	18204	47	SYT1
4.301e-02	-3.15	cGMP metabolic process	biological process	GO:0046068	17	1	18204	47	PDE2A
4.301e-02	-3.15	negative regulation of receptor internalization	biological process	GO:0002091	17	1	18204	47	DLG4
4.301e-02	-3.15	regulation of excitatory synapse assembly	biological process	GO:1904889	17	1	18204	47	GRID2
4.301e-02	-3.15	regulation of postsynaptic density organization	biological process	GO:1905874	17	1	18204	47	GRID2
4.301e-02	-3.15	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	47	PDE2A
4.301e-02	-3.15	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	47	CACNA1G
4.312e-02	-3.14	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	28	RIMS2,KCNMA1
4.331e-02	-3.14	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	4	10285	29	NRG3,GRIN2B,DLG4,GRIN1
4.340e-02	-3.14	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	4	18204	47	ASIC2,NRXN1,TENM1,GRID2
4.367e-02	-3.13	HAL (histidine ammonia-lyase)	protein interactions	3034	132	2	19454	49	HCN1,KCTD16
4.378e-02	-3.13	response to organophosphorus	biological process	GO:0046683	129	2	18204	47	PDE2A,HCN1
4.393e-02	-3.13	fat	COSMIC cancer mutations	fat	117	2	16828	48	HCN1,GRIK2
4.400e-02	-3.12	cytoplasmic region	cellular component	GO:0099568	307	3	19108	49	RIMS2,DLG4,GRIK2
4.420e-02	-3.12	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	1	10285	29	NRG3
4.420e-02	-3.12	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	29	NRG3
4.427e-02	-3.12	GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1)	protein interactions	2554	133	2	19454	49	GABRB2,GABRA1
4.440e-02	-3.11	detection of external stimulus	biological process	GO:0009581	130	2	18204	47	ASIC2,GRIK2
4.440e-02	-3.11	GNA14 (G protein subunit alpha 14)	protein interactions	9630	18	1	19454	49	CHRM2
4.440e-02	-3.11	APOBEC1 (apolipoprotein B mRNA editing enzyme catalytic subunit 1)	protein interactions	339	18	1	19454	49	CELF2
4.440e-02	-3.11	RHBDL1 (rhomboid like 1)	protein interactions	9028	18	1	19454	49	DLG3
4.440e-02	-3.11	MVB12B (multivesicular body subunit 12B)	protein interactions	89853	18	1	19454	49	PDE2A
4.455e-02	-3.11	YojJ-like	gene3d domains	1.10.287.770	14	1	14470	47	ASIC2
4.487e-02	-3.10	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	49	PDE2A,SYT1
4.487e-02	-3.10	MDH1 (malate dehydrogenase 1)	protein interactions	4190	134	2	19454	49	CHRM2,CSMD2
4.503e-02	-3.10	MTABOTROPICR	prints domains	PR00593	8	1	5227	30	GRM7
4.519e-02	-3.10	calyx of Held	cellular component	GO:0044305	18	1	19108	49	KCNC1
4.547e-02	-3.09	SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase)	protein interactions	6400	135	2	19454	49	GABRA1,NTRK3
4.547e-02	-3.09	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	2	19454	49	NTRK3,GRIN1
4.549e-02	-3.09	negative regulation of lyase activity	biological process	GO:0051350	18	1	18204	47	GABBR2
4.549e-02	-3.09	phagolysosome assembly	biological process	GO:0001845	18	1	18204	47	SYT7
4.549e-02	-3.09	negative regulation of vascular permeability	biological process	GO:0043116	18	1	18204	47	PDE2A
4.549e-02	-3.09	regulation of calcium ion transport into cytosol	biological process	GO:0010522	18	1	18204	47	GRIN1
4.549e-02	-3.09	regulation of acrosome reaction	biological process	GO:0060046	18	1	18204	47	CACNA1H
4.549e-02	-3.09	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	47	DLG4
4.549e-02	-3.09	secretory granule localization	biological process	GO:0032252	18	1	18204	47	CADPS
4.608e-02	-3.08	AHCYL2 (adenosylhomocysteinase like 2)	protein interactions	23382	136	2	19454	49	FGF12,NTRK3
4.608e-02	-3.08	NUDT19 (nudix hydrolase 19)	protein interactions	390916	136	2	19454	49	ALK,NTRK3
4.615e-02	-3.08	cell cortex	cellular component	GO:0005938	313	3	19108	49	DLG4,GRM7,RIMS2
4.625e-02	-3.07	detection of abiotic stimulus	biological process	GO:0009582	133	2	18204	47	ASIC2,GRIK2
4.626e-02	-3.07	CNMP_BINDING_1	prosite domains	PS00888	16	1	12186	36	HCN1
4.650e-02	-3.07	response to light stimulus	biological process	GO:0009416	312	3	18204	47	KCNC1,ASIC2,GRIN1
4.671e-02	-3.06	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	48	NRG3
4.671e-02	-3.06	adrenergic receptor binding	molecular function	GO:0031690	18	1	18094	48	DLG4
4.677e-02	-3.06	human chr7q31.1	chromosome location	human chr7q31.1	25	1	26134	50	GPR85
4.681e-02	-3.06	PLCB2 (phospholipase C beta 2)	protein interactions	5330	19	1	19454	49	ALK
4.681e-02	-3.06	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	49	NRXN1
4.681e-02	-3.06	ADRB1 (adrenoceptor beta 1)	protein interactions	153	19	1	19454	49	DLG4
4.681e-02	-3.06	PEX2 (peroxisomal biogenesis factor 2)	protein interactions	5828	19	1	19454	49	PDE2A
4.681e-02	-3.06	NANOS1 (nanos C2HC-type zinc finger 1)	protein interactions	340719	19	1	19454	49	GRIN1
4.681e-02	-3.06	CRIM1 (cysteine rich transmembrane BMP regulator 1)	protein interactions	51232	19	1	19454	49	CACNA1A
4.690e-02	-3.06	Trafficking of GluR2-containing AMPA receptors	REACTOME pathways	R-HSA-416993	17	1	10285	29	GRIA3
4.690e-02	-3.06	RHO GTPases activate CIT	REACTOME pathways	R-HSA-5625900	17	1	10285	29	DLG4
4.690e-02	-3.06	Acetylcholine Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-264642	17	1	10285	29	SYT1
4.714e-02	-3.05	OLF	smart domains	SM00284	13	1	9717	36	OLFM1
4.723e-02	-3.05	regulation of developmental growth	biological process	GO:0048638	314	3	18204	47	SYT1,OLFM1,RIMS2
4.730e-02	-3.05	FUT8 (fucosyltransferase 8)	protein interactions	2530	138	2	19454	49	GABRD,PDE2A
4.730e-02	-3.05	SYAP1 (synapse associated protein 1)	protein interactions	94056	138	2	19454	49	ALK,NTRK3
4.742e-02	-3.05	thymic_carcinoma	COSMIC cancer mutations	thymic_carcinoma	17	1	16828	48	ALK
4.742e-02	-3.05	bone-sacrum-chordoma	COSMIC cancer mutations	bone-sacrum-chordoma	17	1	16828	48	ALK
4.752e-02	-3.05	MAM_dom	interpro domains	IPR000998	18	1	18521	50	ALK
4.754e-02	-3.05	Rap1 signaling pathway	KEGG pathways	ko04015	210	3	7161	28	GRIN2B,GRIN1,FGF12
4.754e-02	-3.05	Rap1 signaling pathway	KEGG pathways	hsa04015	210	3	7161	28	GRIN1,FGF12,GRIN2B
4.761e-02	-3.04	secretory granule membrane	cellular component	GO:0030667	317	3	19108	49	CADPS,SYT1,STXBP5
4.785e-02	-3.04	anion binding	molecular function	GO:0043168	2412	11	18094	48	GPHN,GRIN1,GRIN2B,HCN1,SYT1,NTRK3,SCN8A,GRM7,PDE2A,SYT7,ALK
4.791e-02	-3.04	protein kinase activator activity	molecular function	GO:0030295	132	2	18094	48	NRG3,ALK
4.792e-02	-3.04	EXOC3 (exocyst complex component 3)	protein interactions	11336	139	2	19454	49	DLG3,GRIN2B
4.792e-02	-3.04	MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking)	protein interactions	23041	139	2	19454	49	NTRK3,PDE2A
4.795e-02	-3.04	positive regulation of reactive oxygen species biosynthetic process	biological process	GO:1903428	19	1	18204	47	GRIN1
4.795e-02	-3.04	regulation of synaptic vesicle endocytosis	biological process	GO:1900242	19	1	18204	47	SYT7
4.795e-02	-3.04	regulation of glutamate secretion	biological process	GO:0014048	19	1	18204	47	GRM7
4.795e-02	-3.04	excretion	biological process	GO:0007588	19	1	18204	47	KCNMA1
4.795e-02	-3.04	presynapse assembly	biological process	GO:0099054	19	1	18204	47	CNTN5
4.814e-02	-3.03	regulation of MAP kinase activity	biological process	GO:0043405	136	2	18204	47	TENM1,NTRK3
4.844e-02	-3.03	MAM	pfam domains	PF00629	18	1	17795	49	ALK
4.853e-02	-3.03	STX3 (syntaxin 3)	protein interactions	6809	140	2	19454	49	SYT1,STXBP5
4.884e-02	-3.02	clathrin-coated vesicle membrane	cellular component	GO:0030665	138	2	19108	49	CHRM2,SYT1
4.916e-02	-3.01	LLGL1 (LLGL scribble cell polarity complex component 1)	protein interactions	3996	141	2	19454	49	CACNA1A,NTRK3
4.921e-02	-3.01	EPCAM (epithelial cell adhesion molecule)	protein interactions	4072	20	1	19454	49	NTRK3
4.921e-02	-3.01	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	1	19454	49	NRXN1
4.921e-02	-3.01	DOK5 (docking protein 5)	protein interactions	55816	20	1	19454	49	NTRK3
4.921e-02	-3.01	GGT1 (gamma-glutamyltransferase 1)	protein interactions	2678	20	1	19454	49	KCNMA1
4.921e-02	-3.01	RGS7 (regulator of G protein signaling 7)	protein interactions	6000	20	1	19454	49	CHRM2
4.921e-02	-3.01	VMAC (vimentin type intermediate filament associated coiled-coil protein)	protein interactions	400673	20	1	19454	49	DLG4
4.921e-02	-3.01	CRHR1 (corticotropin releasing hormone receptor 1)	protein interactions	1394	20	1	19454	49	DLG4
4.921e-02	-3.01	PMM1 (phosphomannomutase 1)	protein interactions	5372	20	1	19454	49	CACNA1A
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	SCN8A
4.945e-02	-3.01	Ig_I-set	interpro domains	IPR013098	132	2	18521	50	NTRK3,CNTN5
4.946e-02	-3.01	ovary-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-small_cell_carcinoma	125	2	16828	48	ALK,NTRK3
4.960e-02	-3.00	Serotonin Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-181429	18	1	10285	29	SYT1
4.960e-02	-3.00	Norepinephrine Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-181430	18	1	10285	29	SYT1
4.963e-02	-3.00	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	3	16828	48	ALK,NTRK3,NRG3
4.963e-02	-3.00	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	3	16828	48	ALK,NRG3,NTRK3
4.979e-02	-3.00	vesicle	cellular component	GO:0031982	4141	16	19108	49	NRXN1,CADPS,CHRM2,SCN8A,GRIN1,GABRB2,GRIA3,GRIN2B,RIMS2,ALK,MCTP1,SYT7,GABRA1,SYT1,DLG4,STXBP5
4.983e-02	-3.00	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	49	NTRK3,ALK