Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
3.560e-12	-26.36	PH-like_dom_sf	interpro domains	IPR011993	431	14	18521	49	IPCEF1,ELMO1,PLCG2,ARHGAP27,WDFY4,VAV1,GAB1,TLN1,SKAP1,ARAP1,CARMIL3,ARHGAP15,PREX1,AKAP13
3.619e-12	-26.34	regulation of response to stimulus	biological process	GO:0048583	4104	34	18204	49	PLCG2,PREX1,RIN3,CD74,CSF1R,VAV1,ADCY7,AKAP13,PRKCD,SBNO2,PDE11A,GIT2,GSDME,ARAP1,DENND1B,SYK,APOE,PIK3R5,NEK6,P2RY6,GMIP,ARHGAP27,DOCK2,HIF1A,PTAFR,VSIR,ARHGAP15,NCK1,IL6R,RHBDF2,PTPN6,FYB1,BLNK,SKAP1
1.237e-11	-25.12	BLNK (B cell linker)	protein interactions	29760	43	7	19454	49	PLCG2,PTPN6,SYK,NCK1,VAV1,GAB1,TLN1
1.924e-11	-24.67	signal transduction	biological process	GO:0007165	4637	35	18204	49	FYB1,BLNK,PTPN6,ELMO1,SKAP1,DOCK2,GAB1,GMIP,P2RY6,ARHGAP27,IL6R,NCK1,ARHGAP15,TLN1,HIF1A,P2RY2,PTAFR,ARAP1,PDE11A,SYK,APOE,PIK3R5,DENND1B,SEMA4A,IRF5,ARHGAP33,RIN3,CD74,PLCG2,PREX1,ADCY7,AKAP13,PRKCD,CSF1R,VAV1
2.021e-11	-24.63	regulation of immune system process	biological process	GO:0002682	1584	22	18204	49	GSDME,PTPN6,RHBDF2,BLNK,FYB1,DENND1B,IRF5,APOE,SKAP1,SYK,PLCG2,CD74,RIN3,PTAFR,CSF1R,HIF1A,VAV1,PRKCD,VSIR,ADCY7,NCK1,IL6R
4.424e-11	-23.84	regulation of intracellular signal transduction	biological process	GO:1902531	1832	23	18204	49	DOCK2,ARHGAP27,GMIP,P2RY6,NEK6,ARHGAP15,NCK1,HIF1A,PTPN6,CD74,PLCG2,PREX1,PRKCD,AKAP13,VAV1,CSF1R,ARAP1,GSDME,GIT2,PDE11A,PIK3R5,APOE,SYK
4.887e-11	-23.74	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	gene3d domains	2.30.29.30	431	14	14470	47	IPCEF1,PLCG2,ARAP1,WDFY4,ELMO1,SKAP1,AKAP13,ARHGAP27,ARHGAP15,VAV1,PREX1,CARMIL3,GAB1,TLN1
6.659e-11	-23.43	LCP2 (lymphocyte cytosolic protein 2)	protein interactions	3937	54	7	19454	49	PTPN6,PLCG2,VAV1,NCK1,SYK,FYB1,BLNK
7.844e-11	-23.27	PH_domain	interpro domains	IPR001849	266	11	18521	49	ARAP1,SKAP1,GAB1,VAV1,AKAP13,ARHGAP27,PREX1,PLCG2,ELMO1,IPCEF1,ARHGAP15
1.411e-10	-22.68	cellular response to stimulus	biological process	GO:0051716	6307	39	18204	49	BLNK,FYB1,PTPN6,ELMO1,SKAP1,GAB1,DOCK2,ARHGAP27,GMIP,P2RY6,IPCEF1,TLN1,ARHGAP15,NCK1,IL6R,PTAFR,P2RY2,HIF1A,ARAP1,GSDME,SBNO2,PDE11A,APOE,PIK3R5,SYK,DENND1B,SEMA4A,ARHGAP33,IRF5,ASS1,CD74,RIN3,PREX1,PLCG2,PRKCD,ADCY7,AKAP13,CSF1R,VAV1
1.556e-10	-22.58	signaling	biological process	GO:0023052	4968	35	18204	49	ADCY7,AKAP13,PRKCD,CSF1R,VAV1,RIN3,CD74,PLCG2,PREX1,SYK,APOE,PIK3R5,SEMA4A,DENND1B,IRF5,ARHGAP33,ARAP1,PDE11A,ARHGAP15,IL6R,NCK1,TLN1,HIF1A,PTAFR,P2RY2,DOCK2,GAB1,GMIP,P2RY6,ARHGAP27,SKAP1,FYB1,BLNK,ELMO1,PTPN6
2.005e-10	-22.33	cell communication	biological process	GO:0007154	5010	35	18204	49	NCK1,ARHGAP15,IL6R,TLN1,HIF1A,P2RY2,PTAFR,DOCK2,GAB1,GMIP,P2RY6,ARHGAP27,SKAP1,FYB1,BLNK,ELMO1,PTPN6,ADCY7,AKAP13,PRKCD,VAV1,CSF1R,RIN3,CD74,PREX1,PLCG2,SYK,PIK3R5,APOE,ARHGAP33,IRF5,SEMA4A,DENND1B,ARAP1,PDE11A
2.239e-10	-22.22	nucleoside-triphosphatase regulator activity	molecular function	GO:0060589	491	13	18094	47	GMIP,DOCK2,ELMO1,ARAP1,AKAP13,ARHGAP15,GIT2,DENND1B,VAV1,ARHGAP27,ARHGAP33,PREX1,RIN3
2.239e-10	-22.22	GTPase regulator activity	molecular function	GO:0030695	491	13	18094	47	ARAP1,AKAP13,ARHGAP15,ELMO1,DOCK2,GMIP,PREX1,RIN3,ARHGAP33,ARHGAP27,GIT2,DENND1B,VAV1
2.380e-10	-22.16	enzyme binding	molecular function	GO:0019899	2086	23	18094	47	SYK,HIF1A,SKAP1,AKAP13,IRF5,BLNK,PRKCD,CD74,DENND1B,GIT2,APOE,ARHGAP33,PLCG2,NEK6,PREX1,RIN3,DOCK2,NCK1,PTPN6,CSF1R,PTAFR,IL6R,VSIR
2.385e-10	-22.16	immune system process	biological process	GO:0002376	1991	23	18204	49	FYB1,BLNK,SBNO2,PTPN6,SKAP1,SYK,PIK3R5,WDFY4,ASS1,SEMA4A,DENND1B,IRF5,DOCK2,CD74,PLCG2,PREX1,IL6R,NCK1,PRKCD,CSF1R,HIF1A,VAV1,PTAFR
2.527e-10	-22.10	lymphocyte activation	biological process	GO:0046649	476	13	18204	49	PRKCD,NCK1,IL6R,VAV1,CD74,DOCK2,PREX1,PLCG2,SYK,SEMA4A,WDFY4,BLNK,PTPN6
3.257e-10	-21.85	positive regulation of immune system process	biological process	GO:0002684	986	17	18204	49	SKAP1,SYK,DENND1B,IRF5,FYB1,BLNK,GSDME,PTPN6,VSIR,NCK1,IL6R,PRKCD,CSF1R,VAV1,PTAFR,CD74,PLCG2
3.502e-10	-21.77	leukocyte activation	biological process	GO:0045321	599	14	18204	49	WDFY4,SEMA4A,SYK,SBNO2,PTPN6,BLNK,VAV1,IL6R,NCK1,PRKCD,PREX1,PLCG2,DOCK2,CD74
3.887e-10	-21.67	cell activation	biological process	GO:0001775	725	15	18204	49	TLN1,PRKCD,IL6R,NCK1,VAV1,CD74,DOCK2,PLCG2,PREX1,SYK,SEMA4A,WDFY4,BLNK,PTPN6,SBNO2
6.532e-10	-21.15	immune response	biological process	GO:0006955	1349	19	18204	49	PTAFR,CSF1R,VAV1,PRKCD,IL6R,NCK1,PLCG2,CD74,DOCK2,SEMA4A,IRF5,ASS1,PIK3R5,SKAP1,SYK,PTPN6,SBNO2,BLNK,FYB1
9.412e-10	-20.78	plasma membrane	cellular component	GO:0005886	5538	35	19108	49	PLCG2,ARHGAP15,SKAP1,VSIR,VAV1,CSF1R,CDH18,ARAP1,PRKCD,MYO1F,ADCY7,SYK,NCK1,PIK3R5,PTPN6,BLNK,FYB1,DOCK2,RHBDF2,PTAFR,IPCEF1,APOE,TLN1,CARMIL3,PREX1,GMIP,ARHGAP33,CD74,PARVG,SEMA4A,P2RY2,P2RY6,ELMO1,GSDME,IL6R
1.514e-09	-20.31	enzyme regulator activity	molecular function	GO:0030234	1305	18	18094	47	PRKCD,ARHGAP15,ARAP1,AKAP13,NCK1,PIK3R5,ELMO1,GMIP,DOCK2,VSIR,RIN3,PREX1,ARHGAP33,VAV1,DENND1B,GIT2,ARHGAP27,APOE
1.604e-09	-20.25	regulation of immune response	biological process	GO:0050776	944	16	18204	49	APOE,SKAP1,SYK,DENND1B,BLNK,FYB1,GSDME,PTPN6,RHBDF2,PRKCD,VSIR,ADCY7,PTAFR,VAV1,CD74,PLCG2
1.896e-09	-20.08	cell periphery	cellular component	GO:0071944	6020	36	19108	49	PRKCD,MYO1F,ARAP1,SYK,NCK1,ADCY7,PLCG2,VSIR,SKAP1,ARHGAP15,VAV1,CDH18,CSF1R,BLNK,FYB1,PIK3R5,PTPN6,TLN1,CARMIL3,PREX1,ARHGAP33,GMIP,DOCK2,IPCEF1,PTAFR,RHBDF2,APOE,AKAP13,GSDME,IL6R,PARVG,CD74,P2RY2,SEMA4A,P2RY6,ELMO1
1.943e-09	-20.06	SH3 Domains	gene3d domains	2.30.30.40	223	10	14470	47	SKAP1,DOCK2,ELMO1,NCK1,MYO1F,ARHGAP33,VAV1,PLCG2,ARHGAP27,FYB1
3.933e-09	-19.35	SH3-like_dom_sf	interpro domains	IPR036028	212	9	18521	49	NCK1,FYB1,VAV1,ARHGAP33,SKAP1,DOCK2,PLCG2,MYO1F,ARHGAP27
4.242e-09	-19.28	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME pathways	R-HSA-983695	39	6	10285	37	SYK,PTPN6,PLCG2,VAV1,NCK1,BLNK
5.885e-09	-18.95	SH3_domain	interpro domains	IPR001452	222	9	18521	49	DOCK2,PLCG2,ARHGAP27,MYO1F,NCK1,FYB1,VAV1,ARHGAP33,SKAP1
7.159e-09	-18.75	regulation of small GTPase mediated signal transduction	biological process	GO:0051056	306	10	18204	49	VAV1,APOE,AKAP13,ARHGAP15,PREX1,ARHGAP27,GMIP,GIT2,ARAP1,DOCK2
8.611e-09	-18.57	immune response-activating cell surface receptor signaling pathway	biological process	GO:0002429	228	9	18204	49	PLCG2,PTPN6,BLNK,FYB1,DENND1B,VAV1,PRKCD,SKAP1,SYK
9.438e-09	-18.48	T cell activation	biological process	GO:0042110	315	10	18204	49	PTPN6,PREX1,DOCK2,CD74,VAV1,WDFY4,SEMA4A,IL6R,NCK1,SYK
1.199e-08	-18.24	B Cell Receptor Signaling Pathway	WikiPathways	WP23	98	8	5310	26	PTPN6,PLCG2,GAB1,NCK1,SYK,BLNK,PRKCD,VAV1
1.272e-08	-18.18	PH_DOMAIN	prosite domains	PS50003	246	10	12186	44	AKAP13,ARHGAP27,ARAP1,PLCG2,IPCEF1,SKAP1,PREX1,GAB1,VAV1,ARHGAP15
1.295e-08	-18.16	leukocyte differentiation	biological process	GO:0002521	425	11	18204	49	SEMA4A,SYK,SBNO2,BLNK,CSF1R,VAV1,IL6R,PLCG2,PREX1,DOCK2,CD74
1.377e-08	-18.10	SHC1 (SHC adaptor protein 1)	protein interactions	6464	350	10	19454	49	PTPN6,PLCG2,CSF1R,RIN3,VAV1,PRKCD,SYK,ARAP1,HIF1A,GAB1
1.410e-08	-18.08	SH2	interpro domains	IPR000980	109	7	18521	49	PLCG2,SYK,VAV1,NCK1,PTPN6,BLNK,RIN3
1.428e-08	-18.06	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	9	19454	49	BLNK,GAB1,TLN1,SYK,NCK1,RIN3,VAV1,PLCG2,PTPN6
1.814e-08	-17.83	SH2_dom_sf	interpro domains	IPR036860	113	7	18521	49	PLCG2,BLNK,PTPN6,RIN3,SYK,VAV1,NCK1
2.144e-08	-17.66	hemopoiesis	biological process	GO:0030097	688	13	18204	49	SBNO2,PTPN6,BLNK,SEMA4A,SYK,PREX1,PLCG2,DOCK2,CD74,VAV1,HIF1A,CSF1R,IL6R
2.159e-08	-17.65	INPP5D (inositol polyphosphate-5-phosphatase D)	protein interactions	3635	70	6	19454	49	GAB1,CSF1R,SYK,ARAP1,NCK1,PRKCD
2.587e-08	-17.47	response to external stimulus	biological process	GO:0009605	1882	20	18204	49	PTPN6,GSDME,SBNO2,IRF5,SEMA4A,WDFY4,ASS1,SYK,PLCG2,PREX1,GAB1,CD74,DOCK2,PTAFR,VAV1,CSF1R,HIF1A,PRKCD,IL6R,NCK1
2.811e-08	-17.39	enzyme activator activity	molecular function	GO:0008047	599	12	18094	47	PREX1,RIN3,VSIR,PRKCD,ARAP1,ARHGAP15,ARHGAP33,APOE,DOCK2,ARHGAP27,GIT2,GMIP
2.871e-08	-17.37	immune response-regulating cell surface receptor signaling pathway	biological process	GO:0002768	262	9	18204	49	FYB1,BLNK,PTPN6,PLCG2,SYK,SKAP1,PRKCD,VAV1,DENND1B
2.932e-08	-17.35	GTPase activator activity	molecular function	GO:0005096	273	9	18094	47	GMIP,GIT2,DOCK2,ARHGAP27,ARHGAP33,ARHGAP15,ARAP1,RIN3,PREX1
2.934e-08	-17.34	response to stimulus	biological process	GO:0050896	7803	40	18204	49	GAB1,DOCK2,ARHGAP27,GMIP,P2RY6,TLN1,IPCEF1,ARHGAP15,IL6R,NCK1,PTAFR,P2RY2,HIF1A,BLNK,FYB1,PTPN6,ELMO1,SKAP1,WDFY4,CD74,RIN3,PLCG2,PREX1,PRKCD,ADCY7,AKAP13,CSF1R,VAV1,ARAP1,GSDME,PDE11A,SBNO2,APOE,PIK3R5,SYK,DENND1B,SEMA4A,IRF5,ARHGAP33,ASS1
2.983e-08	-17.33	Rho GTPase cycle	REACTOME pathways	R-HSA-194840	142	8	10285	37	VAV1,AKAP13,ARAP1,ARHGAP15,PREX1,ARHGAP33,GMIP,ARHGAP27
3.490e-08	-17.17	MS4A2 (membrane spanning 4-domains A2)	protein interactions	2206	14	4	19454	49	PTPN6,SYK,PRKCD,VAV1
3.710e-08	-17.11	mononuclear cell differentiation	biological process	GO:1903131	364	10	18204	49	CSF1R,VAV1,SEMA4A,SYK,IL6R,PLCG2,PREX1,DOCK2,BLNK,CD74
4.015e-08	-17.03	positive regulation of catalytic activity	biological process	GO:0043085	868	14	18204	49	ARAP1,SYK,APOE,PIK3R5,CD74,P2RY6,GMIP,PREX1,ARHGAP27,VSIR,IL6R,PRKCD,CSF1R,HIF1A
4.896e-08	-16.83	PH	smart domains	SM00233	259	10	9717	39	AKAP13,GAB1,ARHGAP27,SKAP1,PREX1,PLCG2,ARHGAP15,VAV1,ARAP1,IPCEF1
6.307e-08	-16.58	SH2 domain	gene3d domains	3.30.505.10	111	7	14470	47	BLNK,PLCG2,SYK,VAV1,NCK1,PTPN6,RIN3
6.587e-08	-16.54	molecular function regulator activity	molecular function	GO:0098772	2079	20	18094	47	SEMA4A,RIN3,PREX1,VSIR,ARHGAP27,APOE,VAV1,DENND1B,GIT2,ARHGAP33,PIK3R5,ARHGAP15,AKAP13,NCK1,ARAP1,PRKCD,DOCK2,GMIP,ELMO1,HIF1A
6.683e-08	-16.52	endocytosis	biological process	GO:0006897	499	11	18204	49	APOE,SYK,DENND1B,ELMO1,PRKCD,MYO1F,VAV1,DOCK2,RIN3,ARHGAP27,P2RY6
6.740e-08	-16.51	cell surface receptor signaling pathway	biological process	GO:0007166	1992	20	18204	49	SYK,SKAP1,IRF5,SEMA4A,DENND1B,FYB1,BLNK,PTPN6,IL6R,NCK1,PRKCD,TLN1,VAV1,CSF1R,PTAFR,P2RY2,GAB1,CD74,P2RY6,PLCG2
6.863e-08	-16.49	lymphocyte differentiation	biological process	GO:0030098	290	9	18204	49	SYK,IL6R,VAV1,SEMA4A,DOCK2,CD74,BLNK,PREX1,PLCG2
6.917e-08	-16.49	immune effector process	biological process	GO:0002252	389	10	18204	49	SBNO2,PTPN6,PLCG2,DOCK2,CD74,VAV1,SEMA4A,SYK,IL6R,PRKCD
7.659e-08	-16.38	SH3	prosite domains	PS50002	222	9	12186	44	VAV1,SKAP1,ARHGAP33,FYB1,PLCG2,NCK1,ARHGAP27,MYO1F,DOCK2
8.050e-08	-16.34	PLCG2 (phospholipase C gamma 2)	protein interactions	5336	87	6	19454	49	GAB1,BLNK,PTPN6,PLCG2,VAV1,SYK
8.546e-08	-16.28	antigen receptor-mediated signaling pathway	biological process	GO:0050851	139	7	18204	49	FYB1,BLNK,PTPN6,PLCG2,SYK,SKAP1,DENND1B
9.012e-08	-16.22	positive regulation of immune response	biological process	GO:0050778	640	12	18204	49	PRKCD,SYK,SKAP1,PTAFR,DENND1B,VAV1,BLNK,CD74,FYB1,PTPN6,PLCG2,GSDME
9.309e-08	-16.19	EPOR (erythropoietin receptor)	protein interactions	2057	45	5	19454	49	PLCG2,PTPN6,SYK,GAB1,VAV1
9.684e-08	-16.15	SH2	prosite domains	PS50001	107	7	12186	44	SYK,BLNK,VAV1,NCK1,PLCG2,PTPN6,RIN3
9.700e-08	-16.15	immune response-activating signaling pathway	biological process	GO:0002757	302	9	18204	49	FYB1,BLNK,PTPN6,PLCG2,SYK,SKAP1,PRKCD,VAV1,DENND1B
1.081e-07	-16.04	positive regulation of response to stimulus	biological process	GO:0048584	2266	21	18204	49	FYB1,BLNK,PTPN6,GSDME,SYK,SKAP1,PIK3R5,APOE,DENND1B,CD74,P2RY6,NEK6,PLCG2,IL6R,NCK1,AKAP13,PRKCD,VAV1,CSF1R,HIF1A,PTAFR
1.425e-07	-15.76	SH2	smart domains	SM00252	103	7	9717	39	NCK1,PTPN6,SYK,RIN3,BLNK,PLCG2,VAV1
1.546e-07	-15.68	CBLB (Cbl proto-oncogene B)	protein interactions	868	97	6	19454	49	PLCG2,FYB1,VAV1,NCK1,BLNK,SYK
1.564e-07	-15.67	protein kinase binding	molecular function	GO:0019901	701	12	18094	47	NEK6,BLNK,PRKCD,NCK1,IRF5,PTPN6,HIF1A,ARHGAP33,PLCG2,SKAP1,PTAFR,SYK
1.814e-07	-15.52	intracellular signal transduction	biological process	GO:0035556	1505	17	18204	49	AKAP13,ADCY7,PRKCD,VAV1,HIF1A,DOCK2,GMIP,PLCG2,PREX1,SYK,PIK3R5,APOE,ARHGAP33,BLNK,PDE11A,ELMO1,PTPN6
2.741e-07	-15.11	regulation of signal transduction	biological process	GO:0009966	3114	24	18204	49	GSDME,PTPN6,PDE11A,RHBDF2,GIT2,ARAP1,APOE,PIK3R5,SYK,PLCG2,PREX1,ARHGAP27,NEK6,GMIP,P2RY6,CD74,DOCK2,CSF1R,HIF1A,VAV1,PRKCD,NCK1,ARHGAP15,AKAP13
2.835e-07	-15.08	Signal Transduction	REACTOME pathways	R-HSA-162582	2547	24	10285	37	ADCY7,PTAFR,TLN1,SYK,APOE,ARAP1,VAV1,PDE11A,PREX1,P2RY6,HIF1A,PRKCD,ARHGAP27,IL6R,PIK3R5,P2RY2,ELMO1,AKAP13,ARHGAP15,NCK1,PTPN6,GMIP,ARHGAP33,GAB1
2.994e-07	-15.02	chemotaxis	biological process	GO:0006935	345	9	18204	49	DOCK2,GAB1,PREX1,IL6R,SYK,PRKCD,VAV1,SEMA4A,PTAFR
3.038e-07	-15.01	positive regulation of molecular function	biological process	GO:0044093	1192	15	18204	49	PIK3R5,APOE,SYK,ARAP1,PRKCD,IL6R,VSIR,HIF1A,CSF1R,CD74,PLCG2,PREX1,ARHGAP27,GMIP,P2RY6
3.113e-07	-14.98	SH2	pfam domains	PF00017	100	6	17795	49	SYK,PLCG2,PTPN6,NCK1,BLNK,VAV1
3.144e-07	-14.97	taxis	biological process	GO:0042330	347	9	18204	49	SYK,IL6R,PRKCD,VAV1,PTAFR,SEMA4A,DOCK2,GAB1,PREX1
3.145e-07	-14.97	cellular response to chemical stimulus	biological process	GO:0070887	2411	21	18204	49	CSF1R,HIF1A,VAV1,P2RY2,PTAFR,IL6R,ADCY7,IPCEF1,PRKCD,P2RY6,PLCG2,PREX1,CD74,GAB1,ASS1,IRF5,SYK,APOE,SBNO2,GSDME,PTPN6
3.256e-07	-14.94	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	11	19454	49	TLN1,FYB1,IL6R,GAB1,HIF1A,SYK,SKAP1,P2RY2,PRKCD,PTPN6,CSF1R
3.268e-07	-14.93	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	6	19454	49	PLCG2,CSF1R,PTPN6,SYK,NCK1,BLNK
3.716e-07	-14.81	positive regulation of cell migration	biological process	GO:0030335	592	11	18204	49	PLCG2,PREX1,P2RY6,GAB1,CD74,PTAFR,SEMA4A,HIF1A,CSF1R,IL6R,VSIR
3.836e-07	-14.77	regulation of catalytic activity	biological process	GO:0050790	1395	16	18204	49	ARAP1,SYK,PIK3R5,APOE,CD74,P2RY6,GMIP,PREX1,ARHGAP27,ARHGAP15,IL6R,VSIR,PRKCD,VAV1,HIF1A,CSF1R
3.898e-07	-14.76	regulation of body fluid levels	biological process	GO:0050878	356	9	18204	49	SYK,APOE,PRKCD,TLN1,VAV1,HIF1A,P2RY2,PTPN6,PLCG2
4.351e-07	-14.65	positive regulation of immune effector process	biological process	GO:0002699	261	8	18204	49	PLCG2,PTPN6,CD74,VAV1,DENND1B,PTAFR,IRF5,SYK
4.740e-07	-14.56	regulation of cell migration	biological process	GO:0030334	1061	14	18204	49	SEMA4A,APOE,P2RY6,PREX1,PLCG2,RIN3,CD74,GAB1,CSF1R,HIF1A,PTAFR,VSIR,NCK1,IL6R
4.917e-07	-14.53	kinase binding	molecular function	GO:0019900	780	12	18094	47	PTPN6,IRF5,NCK1,BLNK,NEK6,PRKCD,SYK,PTAFR,PLCG2,SKAP1,HIF1A,ARHGAP33
5.030e-07	-14.50	locomotion	biological process	GO:0040011	367	9	18204	49	VAV1,SEMA4A,PTAFR,SYK,IL6R,PRKCD,PREX1,DOCK2,GAB1
5.146e-07	-14.48	activation of immune response	biological process	GO:0002253	368	9	18204	49	SYK,SKAP1,PRKCD,VAV1,DENND1B,FYB1,BLNK,PTPN6,PLCG2
5.146e-07	-14.48	immune response-regulating signaling pathway	biological process	GO:0002764	368	9	18204	49	DENND1B,VAV1,PRKCD,SKAP1,SYK,PLCG2,PTPN6,BLNK,FYB1
5.361e-07	-14.44	T cell differentiation	biological process	GO:0030217	182	7	18204	49	PREX1,CD74,DOCK2,SEMA4A,VAV1,IL6R,SYK
5.412e-07	-14.43	Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME pathways	R-HSA-2029480	86	6	10285	37	NCK1,VAV1,PRKCD,PLCG2,ELMO1,SYK
5.781e-07	-14.36	positive regulation of cell motility	biological process	GO:2000147	619	11	18204	49	SEMA4A,VSIR,IL6R,PTAFR,CSF1R,HIF1A,CD74,GAB1,PREX1,PLCG2,P2RY6
6.317e-07	-14.27	molecular function activator activity	molecular function	GO:0140677	1132	14	18094	47	DOCK2,ARHGAP27,APOE,GMIP,GIT2,ARHGAP33,HIF1A,ARHGAP15,ARAP1,SEMA4A,RIN3,PREX1,PRKCD,VSIR
7.015e-07	-14.17	regulation of cell-cell adhesion	biological process	GO:0022407	500	10	18204	49	PTAFR,VAV1,ASS1,PRKCD,NCK1,SYK,SKAP1,VSIR,PTPN6,CD74
7.205e-07	-14.14	positive regulation of leukocyte cell-cell adhesion	biological process	GO:1903039	279	8	18204	49	PTAFR,VAV1,SKAP1,VSIR,SYK,NCK1,PTPN6,CD74
7.207e-07	-14.14	positive regulation of locomotion	biological process	GO:0040017	633	11	18204	49	SEMA4A,GAB1,CD74,P2RY6,PLCG2,PREX1,IL6R,VSIR,HIF1A,CSF1R,PTAFR
7.340e-07	-14.12	regulation of leukocyte cell-cell adhesion	biological process	GO:1903037	384	9	18204	49	PTAFR,ASS1,VAV1,SKAP1,VSIR,SYK,NCK1,PTPN6,CD74
7.440e-07	-14.11	VAV1 (vav guanine nucleotide exchange factor 1)	protein interactions	7409	204	7	19454	49	VAV1,SYK,DOCK2,PTPN6,PLCG2,BLNK,GAB1
7.483e-07	-14.11	PH	pfam domains	PF00169	187	7	17795	49	GAB1,SKAP1,VAV1,ARHGAP15,ARHGAP27,IPCEF1,ARAP1
7.705e-07	-14.08	RhoGAP_dom	interpro domains	IPR000198	65	5	18521	49	ARHGAP27,GMIP,ARAP1,ARHGAP33,ARHGAP15
7.987e-07	-14.04	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	13	19454	49	ARHGAP27,PREX1,GAB1,EHBP1L1,ARHGAP33,NCK1,PRKCD,ARHGAP15,GMIP,GIT2,VAV1,ARAP1,DOCK2
9.115e-07	-13.91	phosphorylation-dependent protein binding	molecular function	GO:0140031	8	3	18094	47	PTPN6,VAV1,PLCG2
9.287e-07	-13.89	regulation of cell motility	biological process	GO:2000145	1122	14	18204	49	GAB1,CD74,RIN3,PREX1,PLCG2,P2RY6,NCK1,IL6R,VSIR,PTAFR,CSF1R,HIF1A,APOE,SEMA4A
9.365e-07	-13.88	RhoGAP	pfam domains	PF00620	65	5	17795	49	ARHGAP33,ARHGAP27,GMIP,ARHGAP15,ARAP1
9.515e-07	-13.87	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	17	18204	49	PTPN6,SYK,APOE,IRF5,SEMA4A,DENND1B,GAB1,CD74,PLCG2,IL6R,NCK1,VSIR,VAV1,CSF1R,HIF1A,P2RY2,PTAFR
1.045e-06	-13.77	leukocyte activation involved in immune response	biological process	GO:0002366	201	7	18204	49	DOCK2,CD74,SBNO2,PLCG2,IL6R,SYK,SEMA4A
1.074e-06	-13.74	SH3	smart domains	SM00326	202	8	9717	39	SKAP1,FYB1,NCK1,ARHGAP33,VAV1,PLCG2,DOCK2,MYO1F
1.077e-06	-13.74	regulation of cell adhesion	biological process	GO:0030155	807	12	18204	49	CD74,PREX1,NCK1,VSIR,TLN1,PRKCD,VAV1,PTAFR,PTPN6,SYK,SKAP1,ASS1
1.169e-06	-13.66	cellular response to organic substance	biological process	GO:0071310	1716	17	18204	49	SYK,ASS1,IRF5,SBNO2,PTPN6,GSDME,ADCY7,IL6R,PRKCD,CSF1R,HIF1A,P2RY2,PTAFR,GAB1,CD74,P2RY6,PLCG2
1.193e-06	-13.64	cell activation involved in immune response	biological process	GO:0002263	205	7	18204	49	IL6R,SYK,SEMA4A,CD74,DOCK2,PLCG2,SBNO2
1.267e-06	-13.58	GPVI-mediated activation cascade	REACTOME pathways	R-HSA-114604	54	5	10285	37	PTPN6,SYK,VAV1,PLCG2,PIK3R5
1.400e-06	-13.48	positive regulation of chemokine production	biological process	GO:0032722	72	5	18204	49	CSF1R,HIF1A,IL6R,SYK,CD74
1.439e-06	-13.45	regulation of locomotion	biological process	GO:0040012	1164	14	18204	49	PTAFR,HIF1A,CSF1R,VSIR,IL6R,NCK1,PREX1,PLCG2,P2RY6,CD74,GAB1,RIN3,SEMA4A,APOE
1.444e-06	-13.45	biological process involved in interspecies interaction between organisms	biological process	GO:0044419	1540	16	18204	49	SBNO2,PTPN6,GSDME,SYK,APOE,ASS1,WDFY4,IRF5,CD74,PLCG2,NCK1,IL6R,PRKCD,HIF1A,CSF1R,PTAFR
1.606e-06	-13.34	import into cell	biological process	GO:0098657	687	11	18204	49	APOE,SYK,DENND1B,ELMO1,PRKCD,MYO1F,VAV1,DOCK2,RIN3,ARHGAP27,P2RY6
1.671e-06	-13.30	response to other organism	biological process	GO:0051707	1363	15	18204	49	PLCG2,CD74,HIF1A,CSF1R,PTAFR,NCK1,IL6R,PRKCD,SBNO2,GSDME,PTPN6,ASS1,WDFY4,IRF5,SYK
1.717e-06	-13.27	response to external biotic stimulus	biological process	GO:0043207	1366	15	18204	49	SBNO2,PTPN6,GSDME,WDFY4,ASS1,IRF5,SYK,PLCG2,CD74,CSF1R,HIF1A,PTAFR,IL6R,NCK1,PRKCD
1.733e-06	-13.27	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	9	19454	49	GAB1,IL6R,PLCG2,PTPN6,SKAP1,SYK,PRKCD,RIN3,VAV1
1.885e-06	-13.18	guanyl-nucleotide exchange factor activity	molecular function	GO:0005085	228	7	18094	47	AKAP13,RIN3,PREX1,VAV1,DENND1B,DOCK2,ELMO1
1.910e-06	-13.17	regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050730	220	7	18204	49	CD74,PLCG2,PTPN6,PRKCD,SYK,IL6R,CSF1R
2.041e-06	-13.10	cytosol	cellular component	GO:0005829	5475	30	19108	49	PDE11A,ELMO1,ARHGAP27,GSDME,DOCK2,ASS1,AKAP13,TLN1,PREX1,ARHGAP33,GMIP,NEK6,PIK3R5,PTPN6,BLNK,HIF1A,GAB1,FYB1,PLCG2,ARHGAP15,SKAP1,VAV1,IRF5,MYO1F,PRKCD,DENND1B,ARAP1,NCK1,SYK,RIN3
2.174e-06	-13.04	regulation of cytokine production	biological process	GO:0001817	863	12	18204	49	PTPN6,DENND1B,IRF5,SYK,PLCG2,CD74,PTAFR,CSF1R,HIF1A,VSIR,IL6R,ADCY7
2.239e-06	-13.01	Rho GTPase activation protein	gene3d domains	1.10.555.10	66	5	14470	47	ARHGAP15,ARHGAP27,GMIP,ARAP1,ARHGAP33
2.418e-06	-12.93	positive regulation of cell-cell adhesion	biological process	GO:0022409	328	8	18204	49	CD74,PTPN6,VSIR,SKAP1,NCK1,SYK,VAV1,PTAFR
2.507e-06	-12.90	response to biotic stimulus	biological process	GO:0009607	1408	15	18204	49	GSDME,PTPN6,SBNO2,IRF5,WDFY4,ASS1,SYK,PLCG2,CD74,PTAFR,CSF1R,HIF1A,PRKCD,NCK1,IL6R
2.518e-06	-12.89	positive regulation of cytokine production involved in immune response	biological process	GO:0002720	81	5	18204	49	IRF5,DENND1B,PLCG2,CD74,SYK
2.527e-06	-12.89	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	11	19454	49	GAB1,IRF5,NCK1,BLNK,PTPN6,CSF1R,SYK,ARAP1,SKAP1,RIN3,VAV1
2.736e-06	-12.81	SYK (spleen associated tyrosine kinase)	protein interactions	6850	248	7	19454	49	PLCG2,PTPN6,NCK1,SYK,VAV1,GAB1,BLNK
2.971e-06	-12.73	regulation of signaling	biological process	GO:0023051	3534	24	18204	49	PTPN6,RHBDF2,DOCK2,ARHGAP27,NEK6,P2RY6,GMIP,NCK1,ARHGAP15,HIF1A,ARAP1,GSDME,PDE11A,GIT2,APOE,PIK3R5,SYK,CD74,PREX1,PLCG2,PRKCD,AKAP13,CSF1R,VAV1
3.081e-06	-12.69	regulation of cell communication	biological process	GO:0010646	3541	24	18204	49	PTPN6,RHBDF2,ARHGAP27,P2RY6,GMIP,NEK6,DOCK2,HIF1A,ARHGAP15,NCK1,GSDME,GIT2,PDE11A,ARAP1,PIK3R5,APOE,SYK,PLCG2,PREX1,CD74,VAV1,CSF1R,PRKCD,AKAP13
3.249e-06	-12.64	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	5	19454	49	NCK1,PRKCD,GAB1,CSF1R,PTPN6
3.415e-06	-12.59	RHOGAP	prosite domains	PS50238	65	5	12186	44	ARAP1,ARHGAP27,ARHGAP33,GMIP,ARHGAP15
3.574e-06	-12.54	myeloid leukocyte activation	biological process	GO:0002274	155	6	18204	49	PRKCD,DOCK2,SYK,PREX1,PLCG2,SBNO2
3.900e-06	-12.45	GAB1 (GRB2 associated binding protein 1)	protein interactions	2549	168	6	19454	49	PLCG2,VAV1,NCK1,SYK,GAB1,BLNK
3.901e-06	-12.45	Rho_GTPase_activation_prot	interpro domains	IPR008936	90	5	18521	49	ARAP1,ARHGAP27,GMIP,ARHGAP33,ARHGAP15
4.160e-06	-12.39	SH2 domain binding	molecular function	GO:0042169	42	4	18094	47	PTPN6,SYK,BLNK,SKAP1
4.259e-06	-12.37	cell migration	biological process	GO:0016477	921	12	18204	49	CARMIL3,SYK,SEMA4A,GAB1,CDH18,DOCK2,PREX1,PRKCD,NCK1,IL6R,VAV1,HIF1A
4.313e-06	-12.35	SH2DOMAIN	prints domains	PR00401	72	5	5227	19	SYK,PLCG2,VAV1,NCK1,PTPN6
4.596e-06	-12.29	cell motility	biological process	GO:0048870	1101	13	18204	49	PREX1,GAB1,CDH18,DOCK2,VAV1,HIF1A,PRKCD,IL6R,NCK1,ELMO1,CARMIL3,SEMA4A,SYK
4.613e-06	-12.29	G protein-coupled purinergic nucleotide receptor activity	molecular function	GO:0045028	13	3	18094	47	PTAFR,P2RY6,P2RY2
4.682e-06	-12.27	PTK2B (protein tyrosine kinase 2 beta)	protein interactions	2185	98	5	19454	49	SYK,PRKCD,VAV1,TLN1,PTPN6
4.905e-06	-12.23	SH3BP2 (SH3 domain binding protein 2)	protein interactions	6452	45	4	19454	49	PLCG2,MYO1F,SYK,VAV1
5.085e-06	-12.19	positive regulation of cell adhesion	biological process	GO:0045785	486	9	18204	49	SKAP1,VSIR,SYK,NCK1,PTAFR,VAV1,CD74,PREX1,PTPN6
5.123e-06	-12.18	RhoGAP	smart domains	SM00324	64	5	9717	39	ARHGAP15,GMIP,ARHGAP27,ARAP1,ARHGAP33
5.143e-06	-12.18	G protein-coupled purinergic nucleotide receptor signaling pathway	biological process	GO:0035589	13	3	18204	49	PTAFR,P2RY2,P2RY6
5.699e-06	-12.08	GRAP2 (GRB2 related adaptor protein 2)	protein interactions	9402	102	5	19454	49	GAB1,SYK,BLNK,RIN3,CSF1R
5.810e-06	-12.06	B cell receptor signaling pathway	biological process	GO:0050853	44	4	18204	49	SYK,BLNK,PLCG2,PTPN6
6.398e-06	-11.96	positive regulation of cytokine production	biological process	GO:0001819	500	9	18204	49	CSF1R,HIF1A,PTAFR,DENND1B,IRF5,SYK,IL6R,PLCG2,CD74
6.472e-06	-11.95	membrane	cellular component	GO:0016020	9220	39	19108	49	ARHGAP27,GSDME,IL6R,PARVG,CD74,P2RY2,SEMA4A,P2RY6,ELMO1,PREX1,TLN1,CARMIL3,ARHGAP33,GMIP,DOCK2,ASS1,IPCEF1,RHBDF2,PTAFR,AKAP13,APOE,BLNK,FYB1,PIK3R5,EHBP1L1,PTPN6,MYO1F,PRKCD,ARAP1,SYK,NCK1,ADCY7,PLCG2,SKAP1,ARHGAP15,VSIR,VAV1,CDH18,CSF1R
6.566e-06	-11.93	phosphotyrosine residue binding	molecular function	GO:0001784	47	4	18094	47	VAV1,PTPN6,SYK,PLCG2
7.098e-06	-11.86	inositol trisphosphate biosynthetic process	biological process	GO:0032959	2	2	18204	49	PTAFR,PLCG2
7.120e-06	-11.85	positive regulation of interleukin-6 production	biological process	GO:0032755	100	5	18204	49	PTAFR,PLCG2,SYK,IL6R,CD74
7.190e-06	-11.84	regulation of interleukin-6 production	biological process	GO:0032675	175	6	18204	49	SYK,IL6R,PTAFR,CD74,PTPN6,PLCG2
7.476e-06	-11.80	platelet activation	biological process	GO:0030168	101	5	18204	49	SYK,TLN1,VAV1,PLCG2,PTPN6
7.511e-06	-11.80	DOK1 (docking protein 1)	protein interactions	1796	50	4	19454	49	PTPN6,TLN1,VAV1,NCK1
7.588e-06	-11.79	T cell selection	biological process	GO:0045058	47	4	18204	49	DOCK2,SYK,IL6R,CD74
7.673e-06	-11.78	regulation of phosphate metabolic process	biological process	GO:0019220	1154	13	18204	49	PLCG2,P2RY6,CD74,PTAFR,CSF1R,HIF1A,PRKCD,IL6R,NCK1,PTPN6,APOE,PIK3R5,SYK
7.746e-06	-11.77	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	13	18204	49	SYK,APOE,PIK3R5,PTPN6,CSF1R,HIF1A,PTAFR,IL6R,NCK1,PRKCD,P2RY6,PLCG2,CD74
7.845e-06	-11.76	alpha-beta T cell activation	biological process	GO:0046631	102	5	18204	49	DOCK2,IL6R,SYK,SEMA4A,WDFY4
8.259e-06	-11.70	FYN (FYN proto-oncogene, Src family tyrosine kinase)	protein interactions	2534	414	8	19454	49	FYB1,CSF1R,PLCG2,SKAP1,SYK,PRKCD,VAV1,ARHGAP33
8.462e-06	-11.68	response to chemical	biological process	GO:0042221	3743	24	18204	49	SYK,APOE,ASS1,ARHGAP33,IRF5,SEMA4A,SBNO2,PTPN6,GSDME,ADCY7,IL6R,IPCEF1,PRKCD,VAV1,CSF1R,HIF1A,P2RY2,PTAFR,DOCK2,GAB1,CD74,P2RY6,PLCG2,PREX1
8.627e-06	-11.66	regulation of chemokine production	biological process	GO:0032642	104	5	18204	49	IL6R,SYK,CD74,HIF1A,CSF1R
8.641e-06	-11.66	regulation of immune effector process	biological process	GO:0002697	390	8	18204	49	CD74,PTPN6,PLCG2,SYK,VAV1,IRF5,DENND1B,PTAFR
8.669e-06	-11.66	T cell receptor complex	cellular component	GO:0042101	16	3	19108	49	SKAP1,PTPN6,SYK
8.732e-06	-11.65	SH3DOMAIN	prints domains	PR00452	83	5	5227	19	VAV1,PLCG2,MYO1F,NCK1,SKAP1
9.435e-06	-11.57	regulation of MAPK cascade	biological process	GO:0043408	669	10	18204	49	CD74,PLCG2,GSDME,PTPN6,P2RY6,APOE,PRKCD,PIK3R5,SYK,CSF1R
9.863e-06	-11.53	regulation of molecular function	biological process	GO:0065009	2005	17	18204	49	ARHGAP27,PLCG2,PREX1,P2RY6,GMIP,CD74,VAV1,HIF1A,CSF1R,PRKCD,IL6R,ARHGAP15,VSIR,ARAP1,PIK3R5,APOE,SYK
9.913e-06	-11.52	T cell receptor signaling pathway	biological process	GO:0050852	107	5	18204	49	PLCG2,DENND1B,PTPN6,SKAP1,FYB1
1.077e-05	-11.44	B cell receptor signaling pathway	KEGG pathways	ko04662	70	5	7161	31	SYK,PLCG2,PTPN6,VAV1,BLNK
1.077e-05	-11.44	B cell receptor signaling pathway	KEGG pathways	hsa04662	70	5	7161	31	SYK,PLCG2,BLNK,VAV1,PTPN6
1.348e-05	-11.21	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	10	18204	49	IL6R,SYK,NCK1,PRKCD,PIK3R5,CSF1R,PTAFR,CD74,P2RY6,PLCG2
1.348e-05	-11.21	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	10	18204	49	CD74,P2RY6,PLCG2,SYK,IL6R,NCK1,PRKCD,PIK3R5,CSF1R,PTAFR
1.366e-05	-11.20	anchoring junction	cellular component	GO:0070161	902	11	19108	49	VAV1,PTPN6,CDH18,PARVG,SKAP1,GIT2,GAB1,FYB1,NCK1,TLN1,PRKCD
1.428e-05	-11.16	Fc receptor signaling pathway	biological process	GO:0038093	55	4	18204	49	VAV1,PLCG2,SYK,PRKCD
1.437e-05	-11.15	CRKL (CRK like proto-oncogene, adaptor protein)	protein interactions	1399	211	6	19454	49	BLNK,SYK,ELMO1,GAB1,RIN3,DOCK2
1.442e-05	-11.15	Signaling by the B Cell Receptor (BCR)	REACTOME pathways	R-HSA-983705	229	7	10285	37	PTPN6,GAB1,VAV1,NCK1,BLNK,SYK,PLCG2
1.458e-05	-11.14	Signaling by Rho GTPases	REACTOME pathways	R-HSA-194315	426	9	10285	37	ARHGAP27,ARHGAP15,ARAP1,AKAP13,NCK1,VAV1,GMIP,ARHGAP33,PREX1
1.557e-05	-11.07	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	6	19454	49	NCK1,GAB1,ARAP1,SYK,BLNK,GIT2
1.580e-05	-11.06	positive regulation of intracellular signal transduction	biological process	GO:1902533	1048	12	18204	49	SYK,PIK3R5,APOE,PTPN6,GSDME,CSF1R,AKAP13,NCK1,P2RY6,NEK6,PLCG2,CD74
1.723e-05	-10.97	macrophage activation involved in immune response	biological process	GO:0002281	19	3	18204	49	PLCG2,SBNO2,SYK
1.724e-05	-10.97	GAB2 (GRB2 associated binding protein 2)	protein interactions	9846	128	5	19454	49	PLCG2,PTPN6,SYK,NCK1,GAB1
1.724e-05	-10.97	BTK (Bruton tyrosine kinase)	protein interactions	695	128	5	19454	49	PLCG2,VAV1,GAB1,BLNK,SYK
1.731e-05	-10.96	regulation of cytokine production involved in immune response	biological process	GO:0002718	120	5	18204	49	CD74,SYK,IRF5,PLCG2,DENND1B
1.751e-05	-10.95	protein phosphorylated amino acid binding	molecular function	GO:0045309	60	4	18094	47	PLCG2,SYK,PTPN6,VAV1
1.815e-05	-10.92	purinergic nucleotide receptor activity	molecular function	GO:0001614	20	3	18094	47	PTAFR,P2RY6,P2RY2
1.815e-05	-10.92	nucleotide receptor activity	molecular function	GO:0016502	20	3	18094	47	PTAFR,P2RY2,P2RY6
1.916e-05	-10.86	PDGFRB (platelet derived growth factor receptor beta)	protein interactions	5159	222	6	19454	49	GAB1,HIF1A,VAV1,NCK1,PTPN6,CSF1R
1.918e-05	-10.86	regulation of hydrolase activity	biological process	GO:0051336	726	10	18204	49	VAV1,ARHGAP15,SYK,VSIR,PRKCD,P2RY6,GMIP,ARHGAP27,PREX1,ARAP1
1.978e-05	-10.83	G protein-coupled UTP receptor activity	molecular function	GO:0045030	3	2	18094	47	P2RY6,P2RY2
2.023e-05	-10.81	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	GO:0038096	20	3	18204	49	SYK,PRKCD,VAV1
2.023e-05	-10.81	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological process	GO:0002433	20	3	18204	49	SYK,PRKCD,VAV1
2.107e-05	-10.77	cellular response to cytokine stimulus	biological process	GO:0071345	734	10	18204	49	SYK,IL6R,HIF1A,ASS1,CSF1R,IRF5,CD74,SBNO2,PTPN6,GSDME
2.378e-05	-10.65	cell chemotaxis	biological process	GO:0060326	216	6	18204	49	PREX1,GAB1,VAV1,PRKCD,IL6R,SYK
2.388e-05	-10.64	vesicle-mediated transport	biological process	GO:0016192	1283	13	18204	49	GIT2,ELMO1,SYK,APOE,DENND1B,RIN3,DOCK2,P2RY6,ARHGAP27,PRKCD,VAV1,PTAFR,MYO1F
2.723e-05	-10.51	positive regulation of cell adhesion mediated by integrin	biological process	GO:0033630	22	3	18204	49	PTPN6,SKAP1,SYK
2.723e-05	-10.51	Fc receptor mediated stimulatory signaling pathway	biological process	GO:0002431	22	3	18204	49	PRKCD,SYK,VAV1
2.762e-05	-10.50	PE/DAG-bd	interpro domains	IPR002219	66	4	18521	49	GMIP,AKAP13,PRKCD,VAV1
2.815e-05	-10.48	Immune System	REACTOME pathways	R-HSA-168256	2101	19	10285	37	ADCY7,SYK,CD74,PTAFR,TLN1,VAV1,HIF1A,CSF1R,DOCK2,IL6R,PLCG2,PRKCD,ELMO1,FYB1,IRF5,BLNK,NCK1,GAB1,PTPN6
2.882e-05	-10.45	IL6ST (interleukin 6 cytokine family signal transducer)	protein interactions	3572	70	4	19454	49	PRKCD,IL6R,VAV1,PTPN6
2.953e-05	-10.43	regulation of response to external stimulus	biological process	GO:0032101	1116	12	18204	49	VAV1,CSF1R,PRKCD,APOE,SYK,IL6R,PTPN6,PLCG2,RHBDF2,SBNO2,CD74,RIN3
2.953e-05	-10.43	myeloid cell activation involved in immune response	biological process	GO:0002275	66	4	18204	49	PLCG2,SBNO2,DOCK2,SYK
3.056e-05	-10.40	positive regulation of production of molecular mediator of immune response	biological process	GO:0002702	135	5	18204	49	IRF5,DENND1B,PLCG2,SYK,CD74
3.115e-05	-10.38	positive regulation of hydrolase activity	biological process	GO:0051345	466	8	18204	49	VSIR,SYK,PRKCD,P2RY6,GMIP,ARHGAP27,PREX1,ARAP1
3.169e-05	-10.36	CBL (Cbl proto-oncogene)	protein interactions	867	499	8	19454	49	HIF1A,BLNK,FYB1,PTPN6,CSF1R,NCK1,SYK,VAV1
3.322e-05	-10.31	PIK3AP1 (phosphoinositide-3-kinase adaptor protein 1)	protein interactions	118788	25	3	19454	49	PLCG2,SYK,NCK1
3.344e-05	-10.31	phospholipid binding	molecular function	GO:0005543	489	8	18094	47	ARAP1,PREX1,DENND1B,PTAFR,APOE,ARHGAP33,TLN1,GSDME
3.370e-05	-10.30	Regulation of signaling by CBL	REACTOME pathways	R-HSA-912631	18	3	10285	37	SYK,VAV1,BLNK
3.387e-05	-10.29	regulation of actin cytoskeleton organization	biological process	GO:0032956	342	7	18204	49	CSF1R,PRKCD,NCK1,AKAP13,PREX1,ARAP1,CARMIL3
3.464e-05	-10.27	positive regulation of MAPK cascade	biological process	GO:0043410	473	8	18204	49	PIK3R5,APOE,SYK,CSF1R,CD74,PLCG2,GSDME,P2RY6
3.643e-05	-10.22	regulation of cellular component organization	biological process	GO:0051128	2455	18	18204	49	NEK6,PREX1,PLCG2,DOCK2,RIN3,CSF1R,HIF1A,NCK1,AKAP13,PRKCD,TLN1,CARMIL3,ARAP1,ARHGAP33,SEMA4A,SYK,SKAP1,APOE
3.681e-05	-10.21	Fc gamma R-mediated phagocytosis	KEGG pathways	ko04666	90	5	7161	31	PRKCD,SYK,PLCG2,DOCK2,VAV1
3.681e-05	-10.21	Fc gamma R-mediated phagocytosis	KEGG pathways	hsa04666	90	5	7161	31	DOCK2,VAV1,SYK,PRKCD,PLCG2
3.801e-05	-10.18	NHLRC2 (NHL repeat containing 2)	protein interactions	374354	372	7	19454	49	AKAP13,MYO1F,ARHGAP15,SYK,PRKCD,TLN1,ASS1
3.826e-05	-10.17	protein domain specific binding	molecular function	GO:0019904	651	9	18094	47	ARHGAP27,SYK,TLN1,SKAP1,ELMO1,HIF1A,PTPN6,NCK1,BLNK
3.904e-05	-10.15	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	6	19454	49	NCK1,ARAP1,GIT2,FYB1,GAB1,BLNK
3.949e-05	-10.14	G protein-coupled pyrimidinergic nucleotide receptor activity	molecular function	GO:0071553	4	2	18094	47	P2RY6,P2RY2
4.043e-05	-10.12	Fc-epsilon receptor signaling pathway	biological process	GO:0038095	25	3	18204	49	VAV1,PLCG2,SYK
4.194e-05	-10.08	JAK2 (Janus kinase 2)	protein interactions	3717	154	5	19454	49	PTPN6,PLCG2,VAV1,PTAFR,ASS1
4.209e-05	-10.08	SLA (Src like adaptor)	protein interactions	6503	27	3	19454	49	GAB1,SYK,VAV1
4.209e-05	-10.08	CD19 (CD19 molecule)	protein interactions	930	27	3	19454	49	SYK,VAV1,PLCG2
4.209e-05	-10.08	CD72 (CD72 molecule)	protein interactions	971	27	3	19454	49	PTPN6,SYK,BLNK
4.301e-05	-10.05	positive regulation of biological process	biological process	GO:0048518	6326	31	18204	49	PREX1,PLCG2,CD74,CSF1R,VAV1,AKAP13,PRKCD,SBNO2,GSDME,ARAP1,ASS1,SEMA4A,DENND1B,IRF5,SYK,APOE,PIK3R5,NEK6,P2RY6,DOCK2,GAB1,HIF1A,PTAFR,P2RY2,VSIR,NCK1,IL6R,PTPN6,FYB1,BLNK,SKAP1
4.376e-05	-10.04	cell-cell junction	cellular component	GO:0005911	513	8	19108	49	VAV1,GAB1,PTPN6,CDH18,NCK1,TLN1,SKAP1,PRKCD
4.570e-05	-9.99	Cytokine Signaling in Immune system	REACTOME pathways	R-HSA-1280215	756	11	10285	37	CSF1R,HIF1A,VAV1,SYK,TLN1,PTAFR,PTPN6,BLNK,IRF5,PRKCD,IL6R
4.647e-05	-9.98	PTPN6 (protein tyrosine phosphatase non-receptor type 6)	protein interactions	5777	260	6	19454	49	VAV1,SYK,PRKCD,PLCG2,PTPN6,BLNK
4.666e-05	-9.97	positive regulation of signaling	biological process	GO:0023056	1794	15	18204	49	NCK1,AKAP13,PRKCD,CSF1R,HIF1A,CD74,NEK6,P2RY6,PLCG2,SYK,APOE,PIK3R5,ARAP1,GSDME,PTPN6
4.898e-05	-9.92	IL-6 signaling pathway	WikiPathways	WP364	43	4	5310	26	VAV1,IL6R,GAB1,PRKCD
5.038e-05	-9.90	regulation of leukocyte mediated immunity	biological process	GO:0002703	247	6	18204	49	SYK,VAV1,PTPN6,PTAFR,DENND1B,PLCG2
5.249e-05	-9.85	positive regulation of signal transduction	biological process	GO:0009967	1593	14	18204	49	GSDME,PTPN6,APOE,PIK3R5,SYK,PLCG2,NEK6,P2RY6,CD74,HIF1A,CSF1R,PRKCD,NCK1,AKAP13
5.347e-05	-9.84	lung-carcinoma-undifferentiated_carcinoma	COSMIC cancer mutations	lung-carcinoma-undifferentiated_carcinoma	1408	13	16828	45	PTPN6,PIK3R5,VAV1,P2RY2,SYK,PLCG2,RIN3,GAB1,NCK1,CSF1R,TLN1,PRKCD,P2RY6
5.381e-05	-9.83	-	gene3d domains	3.30.60.20	64	4	14470	47	PRKCD,AKAP13,GMIP,VAV1
5.442e-05	-9.82	ZF_DAG_PE_1	prosite domains	PS00479	58	4	12186	44	GMIP,PRKCD,AKAP13,VAV1
5.468e-05	-9.81	PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)	protein interactions	5295	394	7	19454	49	PTPN6,PLCG2,CSF1R,VAV1,SYK,NCK1,GAB1
5.471e-05	-9.81	Hemostasis	REACTOME pathways	R-HSA-109582	632	10	10285	37	PDE11A,PTPN6,VAV1,CD74,SYK,TLN1,PLCG2,PRKCD,PIK3R5,DOCK2
5.496e-05	-9.81	Platelet activation, signaling and aggregation	REACTOME pathways	R-HSA-76002	282	7	10285	37	PTPN6,VAV1,SYK,TLN1,PIK3R5,PLCG2,PRKCD
5.726e-05	-9.77	purinergic nucleotide receptor signaling pathway	biological process	GO:0035590	28	3	18204	49	P2RY6,PTAFR,P2RY2
5.755e-05	-9.76	undifferentiated_carcinoma	COSMIC cancer mutations	undifferentiated_carcinoma	1418	13	16828	45	SYK,VAV1,P2RY2,RIN3,PLCG2,PRKCD,TLN1,P2RY6,GAB1,NCK1,CSF1R,PTPN6,PIK3R5
5.877e-05	-9.74	lipid binding	molecular function	GO:0008289	861	10	18094	47	PREX1,BLNK,ARAP1,FYB1,GSDME,TLN1,ARHGAP33,APOE,DENND1B,PTAFR
6.014e-05	-9.72	positive regulation of T cell activation	biological process	GO:0050870	255	6	18204	49	VSIR,SYK,NCK1,VAV1,CD74,PTPN6
6.235e-05	-9.68	response to cytokine	biological process	GO:0034097	834	10	18204	49	GSDME,PTPN6,SBNO2,CD74,IRF5,ASS1,CSF1R,HIF1A,IL6R,SYK
6.389e-05	-9.66	Regulation of actin dynamics for phagocytic cup formation	REACTOME pathways	R-HSA-2029482	61	4	10285	37	VAV1,NCK1,SYK,ELMO1
6.425e-05	-9.65	intracellular signaling cassette	biological process	GO:0141124	837	10	18204	49	ARHGAP33,APOE,PIK3R5,SYK,AKAP13,PLCG2,PTPN6,ELMO1,PDE11A,DOCK2
6.552e-05	-9.63	T-Cell antigen Receptor (TCR) Signaling Pathway	WikiPathways	WP69	91	5	5310	26	FYB1,PRKCD,SKAP1,VAV1,NCK1
6.614e-05	-9.62	positive regulation of gene expression	biological process	GO:0010628	1212	12	18204	49	BLNK,DENND1B,IRF5,SYK,PLCG2,CD74,HIF1A,CSF1R,PTAFR,VSIR,IL6R,NCK1
6.674e-05	-9.61	phagocytosis	biological process	GO:0006909	159	5	18204	49	P2RY6,VAV1,ELMO1,SYK,PRKCD
6.902e-05	-9.58	PLSCR1 (phospholipid scramblase 1)	protein interactions	5359	171	5	19454	49	ADCY7,PRKCD,P2RY6,DOCK2,VSIR
7.044e-05	-9.56	regulation of actin filament-based process	biological process	GO:0032970	384	7	18204	49	PREX1,CARMIL3,ARAP1,CSF1R,AKAP13,NCK1,PRKCD
7.081e-05	-9.56	positive regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050731	161	5	18204	49	CD74,SYK,IL6R,PLCG2,CSF1R
7.452e-05	-9.50	defense response	biological process	GO:0006952	1431	13	18204	49	IRF5,ASS1,SYK,PTPN6,BLNK,PTAFR,HIF1A,CSF1R,PRKCD,NCK1,IL6R,PLCG2,CD74
7.517e-05	-9.50	regulation of supramolecular fiber organization	biological process	GO:1902903	388	7	18204	49	ARAP1,APOE,PRKCD,NCK1,AKAP13,CARMIL3,PREX1
7.541e-05	-9.49	ZF_DAG_PE_2	prosite domains	PS50081	63	4	12186	44	AKAP13,PRKCD,VAV1,GMIP
7.567e-05	-9.49	Signaling by Interleukins	REACTOME pathways	R-HSA-449147	525	9	10285	37	BLNK,VAV1,PTPN6,HIF1A,CSF1R,IL6R,TLN1,PTAFR,SYK
7.813e-05	-9.46	neutrophil activation	biological process	GO:0042119	31	3	18204	49	PRKCD,SYK,PREX1
8.344e-05	-9.39	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	5	19454	49	VAV1,SYK,NCK1,PTPN6,PLCG2
8.501e-05	-9.37	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	29	16828	45	PREX1,ARHGAP27,MYO1F,IRF5,ARHGAP15,ASS1,PARVG,CDH18,RHBDF2,ELMO1,EHBP1L1,IPCEF1,ADCY7,GAB1,P2RY6,TLN1,PRKCD,DOCK2,ARAP1,P2RY2,VAV1,AKAP13,PLCG2,RIN3,GMIP,CSF1R,PDE11A,BLNK,HIF1A
8.604e-05	-9.36	Fc-gamma receptor signaling pathway	biological process	GO:0038094	32	3	18204	49	VAV1,PRKCD,SYK
8.699e-05	-9.35	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	24	16828	45	RIN3,AKAP13,VAV1,PDE11A,NCK1,BLNK,GMIP,SBNO2,DOCK2,EHBP1L1,P2RY6,TLN1,ADCY7,WDFY4,IPCEF1,ARHGAP15,MYO1F,IRF5,PREX1,RHBDF2,ELMO1,PIK3R5,CDH18,PARVG
8.699e-05	-9.35	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	24	16828	45	ARHGAP15,PREX1,MYO1F,IRF5,RHBDF2,PIK3R5,ELMO1,PARVG,CDH18,EHBP1L1,ADCY7,WDFY4,P2RY6,TLN1,IPCEF1,SBNO2,DOCK2,AKAP13,RIN3,VAV1,PDE11A,NCK1,BLNK,GMIP
8.750e-05	-9.34	cellular response to virus	biological process	GO:0098586	87	4	18204	49	GSDME,IRF5,WDFY4,HIF1A
9.286e-05	-9.28	Mbp (myelin basic protein)	protein interactions	17196	35	3	19454	49	VAV1,FYB1,NCK1
9.459e-05	-9.27	ERBB2 (erb-b2 receptor tyrosine kinase 2)	protein interactions	2064	583	8	19454	49	TLN1,GAB1,BLNK,PLCG2,PTPN6,VAV1,NCK1,SYK
9.614e-05	-9.25	actin cytoskeleton organization	biological process	GO:0030036	547	8	18204	49	PREX1,ELMO1,DOCK2,ARAP1,MYO1F,PARVG,NCK1,TLN1
9.684e-05	-9.24	regulation of GTPase activity	biological process	GO:0043087	278	6	18204	49	GMIP,VAV1,ARHGAP27,PREX1,ARHGAP15,ARAP1
9.849e-05	-9.23	phosphoprotein binding	molecular function	GO:0051219	93	4	18094	47	PTPN6,SYK,VAV1,PLCG2
1.034e-04	-9.18	positive T cell selection	biological process	GO:0043368	34	3	18204	49	CD74,IL6R,DOCK2
1.053e-04	-9.16	Role of phospholipids in phagocytosis	REACTOME pathways	R-HSA-2029485	26	3	10285	37	SYK,PLCG2,PRKCD
1.057e-04	-9.15	inositol trisphosphate metabolic process	biological process	GO:0032957	6	2	18204	49	PLCG2,PTAFR
1.060e-04	-9.15	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	22	16828	45	ARHGAP33,SBNO2,ELMO1,DOCK2,PTPN6,CDH18,ARAP1,ARHGAP15,DENND1B,CSF1R,GAB1,WDFY4,SKAP1,BLNK,PRKCD,IPCEF1,GMIP,AKAP13,PLCG2,GIT2,VAV1,SYK
1.060e-04	-9.15	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	22	16828	45	GMIP,IPCEF1,PRKCD,CSF1R,BLNK,GAB1,WDFY4,SKAP1,SYK,VAV1,GIT2,PLCG2,AKAP13,CDH18,ARAP1,DOCK2,PTPN6,SBNO2,ARHGAP33,ELMO1,ARHGAP15,DENND1B
1.063e-04	-9.15	regulation of cellular process	biological process	GO:0050794	11468	43	18204	49	GSDME,GIT2,SBNO2,PDE11A,ARAP1,IRF5,ARHGAP33,SEMA4A,DENND1B,ASS1,PIK3R5,APOE,SYK,PLCG2,PREX1,CD74,RIN3,VAV1,CSF1R,PRKCD,AKAP13,ADCY7,PTPN6,ELMO1,RHBDF2,BLNK,FYB1,CARMIL3,SKAP1,ARHGAP27,P2RY6,GMIP,NEK6,GAB1,DOCK2,PTAFR,P2RY2,HIF1A,TLN1,ARHGAP15,NCK1,IL6R,VSIR
1.076e-04	-9.14	Chemokine signaling pathway	KEGG pathways	hsa04062	182	6	7161	31	ADCY7,VAV1,DOCK2,ELMO1,PREX1,PRKCD
1.076e-04	-9.14	Chemokine signaling pathway	KEGG pathways	ko04062	182	6	7161	31	ADCY7,VAV1,DOCK2,ELMO1,PRKCD,PREX1
1.078e-04	-9.13	blood coagulation	biological process	GO:0007596	176	5	18204	49	PLCG2,PTPN6,VAV1,TLN1,SYK
1.117e-04	-9.10	inflammatory response	biological process	GO:0006954	559	8	18204	49	BLNK,IRF5,PTAFR,CSF1R,ASS1,HIF1A,IL6R,SYK
1.129e-04	-9.09	granulocyte activation	biological process	GO:0036230	35	3	18204	49	PRKCD,SYK,PREX1
1.129e-04	-9.09	positive regulation of myeloid leukocyte cytokine production involved in immune response	biological process	GO:0061081	35	3	18204	49	PLCG2,SYK,CD74
1.137e-04	-9.08	coagulation	biological process	GO:0050817	178	5	18204	49	TLN1,SYK,PTPN6,PLCG2,VAV1
1.214e-04	-9.02	regulation of protein-containing complex assembly	biological process	GO:0043254	419	7	18204	49	NCK1,SYK,SKAP1,APOE,PRKCD,PREX1,PLCG2
1.258e-04	-8.98	C1	smart domains	SM00109	65	4	9717	39	VAV1,AKAP13,GMIP,PRKCD
1.262e-04	-8.98	hemostasis	biological process	GO:0007599	182	5	18204	49	PLCG2,PTPN6,VAV1,TLN1,SYK
1.278e-04	-8.97	positive regulation of biosynthetic process	biological process	GO:0009891	2697	18	18204	49	SBNO2,BLNK,IRF5,DENND1B,ASS1,APOE,SYK,SKAP1,PLCG2,P2RY6,CD74,PTAFR,CSF1R,HIF1A,PRKCD,NCK1,IL6R,VSIR
1.283e-04	-8.96	integrin-mediated signaling pathway	biological process	GO:0007229	96	4	18204	49	TLN1,SYK,FYB1,VAV1
1.340e-04	-8.92	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	6	18204	49	APOE,CD74,SYK,PTPN6,P2RY6,CSF1R
1.370e-04	-8.90	regulation of protein phosphorylation	biological process	GO:0001932	917	10	18204	49	PTPN6,PLCG2,CD74,CSF1R,PIK3R5,PRKCD,APOE,SYK,NCK1,IL6R
1.384e-04	-8.89	regulation of inflammatory response	biological process	GO:0050727	428	7	18204	49	SBNO2,RHBDF2,PLCG2,PTPN6,SYK,PRKCD,APOE
1.478e-04	-8.82	vascular endothelial growth factor production	biological process	GO:0010573	7	2	18204	49	IL6R,HIF1A
1.506e-04	-8.80	regulation of tumor necrosis factor production	biological process	GO:0032680	189	5	18204	49	VSIR,SYK,PLCG2,PTAFR,PTPN6
1.506e-04	-8.80	regulation of production of molecular mediator of immune response	biological process	GO:0002700	189	5	18204	49	SYK,CD74,IRF5,DENND1B,PLCG2
1.533e-04	-8.78	nef (Nef)	protein interactions	156110	802	9	19454	49	ELMO1,CD74,NCK1,PRKCD,SYK,ADCY7,VAV1,CSF1R,DOCK2
1.609e-04	-8.73	PRAM1 (PML-RARA regulated adaptor molecule 1)	protein interactions	84106	42	3	19454	49	SKAP1,NEK6,APOE
1.628e-04	-8.72	FCERI mediated Ca+2 mobilization	REACTOME pathways	R-HSA-2871809	30	3	10285	37	PLCG2,VAV1,SYK
1.637e-04	-8.72	Platelet activation	KEGG pathways	hsa04611	123	5	7161	31	PIK3R5,PLCG2,SYK,ADCY7,TLN1
1.687e-04	-8.69	response to organic substance	biological process	GO:0010033	2498	17	18204	49	CD74,GAB1,PLCG2,P2RY6,PRKCD,ADCY7,IL6R,P2RY2,PTAFR,HIF1A,CSF1R,GSDME,PTPN6,SBNO2,SYK,IRF5,ASS1
1.704e-04	-8.68	positive regulation of cellular process	biological process	GO:0048522	5719	28	18204	49	GAB1,DOCK2,NEK6,P2RY6,VSIR,NCK1,IL6R,PTAFR,HIF1A,BLNK,PTPN6,SKAP1,CD74,PREX1,PLCG2,PRKCD,AKAP13,CSF1R,VAV1,ARAP1,GSDME,SBNO2,APOE,PIK3R5,SYK,DENND1B,SEMA4A,IRF5
1.743e-04	-8.65	regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903555	195	5	18204	49	PTPN6,PTAFR,PLCG2,SYK,VSIR
1.849e-04	-8.60	ASB9 (ankyrin repeat and SOCS box containing 9)	protein interactions	140462	44	3	19454	49	PLCG2,TLN1,ASS1
1.869e-04	-8.58	LAT (linker for activation of T cells)	protein interactions	27040	113	4	19454	49	VAV1,SYK,PTPN6,PLCG2
1.869e-04	-8.58	positive regulation of cell communication	biological process	GO:0010647	1792	14	18204	49	GSDME,PTPN6,SYK,APOE,PIK3R5,NEK6,P2RY6,PLCG2,CD74,HIF1A,CSF1R,AKAP13,NCK1,PRKCD
1.873e-04	-8.58	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	22	16828	45	GMIP,IPCEF1,TLN1,HIF1A,BLNK,CSF1R,EHBP1L1,VAV1,GIT2,PLCG2,RIN3,AKAP13,ARAP1,CDH18,PTPN6,DOCK2,ELMO1,PIK3R5,RHBDF2,IRF5,MYO1F,PREX1
1.880e-04	-8.58	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	22	16828	45	GIT2,EHBP1L1,TLN1,IPCEF1,PREX1,MYO1F,IRF5,RHBDF2,ELMO1,PIK3R5,PTPN6,CDH18,AKAP13,RIN3,PLCG2,VAV1,CSF1R,BLNK,HIF1A,GMIP,DOCK2,ARAP1
1.961e-04	-8.54	ERBB3 (erb-b2 receptor tyrosine kinase 3)	protein interactions	2065	338	6	19454	49	VAV1,NCK1,SYK,PTPN6,PLCG2,BLNK
1.961e-04	-8.54	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	45	16828	45	GMIP,RIN3,SBNO2,ARAP1,DOCK2,PRKCD,P2RY6,SKAP1,WDFY4,GAB1,IPCEF1,GIT2,PTAFR,SEMA4A,EHBP1L1,APOE,PIK3R5,ELMO1,RHBDF2,CDH18,ASS1,ARHGAP15,CD74,ARHGAP27,IRF5,MYO1F,HIF1A,BLNK,PDE11A,NCK1,CSF1R,PLCG2,AKAP13,VAV1,P2RY2,DENND1B,IL6R,TLN1,ADCY7,SYK,ARHGAP33,PARVG,PTPN6,NEK6,PREX1
1.961e-04	-8.54	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	45	16828	45	BLNK,PDE11A,NCK1,CSF1R,HIF1A,AKAP13,PLCG2,VAV1,P2RY2,DENND1B,IL6R,ADCY7,TLN1,SYK,ARHGAP33,PTPN6,PARVG,NEK6,PREX1,GMIP,RIN3,SBNO2,DOCK2,ARAP1,SKAP1,GAB1,WDFY4,PRKCD,P2RY6,IPCEF1,PTAFR,GIT2,EHBP1L1,APOE,SEMA4A,ELMO1,PIK3R5,RHBDF2,CDH18,ASS1,ARHGAP15,IRF5,MYO1F,CD74,ARHGAP27
1.967e-04	-8.53	regulation of neutrophil degranulation	biological process	GO:0043313	8	2	18204	49	SYK,PTAFR
2.007e-04	-8.51	negative regulation of inflammatory response	biological process	GO:0050728	201	5	18204	49	PRKCD,APOE,SYK,PTPN6,RHBDF2
2.050e-04	-8.49	SH3_1	pfam domains	PF00018	106	4	17795	49	VAV1,NCK1,MYO1F,PLCG2
2.065e-04	-8.49	HACD3 (3-hydroxyacyl-CoA dehydratase 3)	protein interactions	51495	216	5	19454	49	NEK6,RIN3,VAV1,ARHGAP15,P2RY6
2.091e-04	-8.47	signaling adaptor activity	molecular function	GO:0035591	113	4	18094	47	AKAP13,NCK1,BLNK,GAB1
2.097e-04	-8.47	positive regulation of interleukin-12 production	biological process	GO:0032735	43	3	18204	49	SYK,PLCG2,IRF5
2.101e-04	-8.47	negative regulation of cell-cell adhesion	biological process	GO:0022408	203	5	18204	49	VSIR,CD74,PRKCD,ASS1,PTPN6
2.119e-04	-8.46	wound healing	biological process	GO:0042060	321	6	18204	49	TLN1,SYK,PLCG2,PTPN6,HIF1A,VAV1
2.145e-04	-8.45	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	22	16828	45	DOCK2,ARAP1,VAV1,AKAP13,RIN3,PLCG2,GMIP,CSF1R,BLNK,HIF1A,PREX1,IRF5,MYO1F,PTPN6,CDH18,RHBDF2,PIK3R5,ELMO1,EHBP1L1,GIT2,IPCEF1,TLN1
2.175e-04	-8.43	actin filament-based process	biological process	GO:0030029	616	8	18204	49	PREX1,ELMO1,ARAP1,DOCK2,MYO1F,PARVG,TLN1,NCK1
2.212e-04	-8.42	KLRA1P (killer cell lectin like receptor A1, pseudogene)	protein interactions	10748	9	2	19454	49	PTPN6,SYK
2.316e-04	-8.37	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	32	16828	45	EHBP1L1,ADCY7,GAB1,P2RY6,PRKCD,TLN1,IPCEF1,ARHGAP15,ASS1,PREX1,MYO1F,IRF5,ARHGAP27,ARHGAP33,RHBDF2,ELMO1,PARVG,PTPN6,CDH18,AKAP13,PLCG2,RIN3,P2RY2,VAV1,CSF1R,PDE11A,BLNK,HIF1A,GMIP,DENND1B,DOCK2,ARAP1
2.355e-04	-8.35	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	7	10285	37	GAB1,VAV1,SYK,TLN1,PLCG2,ADCY7,PRKCD
2.380e-04	-8.34	positive regulation of lymphocyte activation	biological process	GO:0051251	328	6	18204	49	CD74,NCK1,SYK,VSIR,PTPN6,VAV1
2.407e-04	-8.33	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	39	16828	45	P2RY2,VAV1,RIN3,PLCG2,AKAP13,GMIP,HIF1A,PDE11A,NCK1,CSF1R,BLNK,ARAP1,DOCK2,SYK,EHBP1L1,GIT2,PTAFR,IPCEF1,P2RY6,PRKCD,TLN1,ADCY7,SKAP1,GAB1,WDFY4,CD74,IRF5,MYO1F,PREX1,ARHGAP15,NEK6,ASS1,CDH18,PTPN6,PARVG,ARHGAP33,RHBDF2,PIK3R5,ELMO1
2.407e-04	-8.33	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	39	16828	45	SYK,EHBP1L1,PTAFR,GIT2,IPCEF1,TLN1,PRKCD,P2RY6,SKAP1,GAB1,WDFY4,ADCY7,MYO1F,IRF5,CD74,PREX1,ASS1,NEK6,ARHGAP15,CDH18,PTPN6,PARVG,ELMO1,PIK3R5,ARHGAP33,RHBDF2,VAV1,P2RY2,PLCG2,RIN3,AKAP13,GMIP,HIF1A,BLNK,NCK1,PDE11A,CSF1R,ARAP1,DOCK2
2.532e-04	-8.28	regulation of cell activation	biological process	GO:0050865	630	8	18204	49	PTPN6,CD74,VAV1,APOE,PRKCD,NCK1,SYK,VSIR
2.539e-04	-8.28	regulation of multicellular organismal process	biological process	GO:0051239	3113	19	18204	49	PTPN6,SYK,APOE,DENND1B,SEMA4A,IRF5,CD74,GAB1,PLCG2,VSIR,NCK1,IL6R,ADCY7,PRKCD,HIF1A,CSF1R,VAV1,PTAFR,P2RY2
2.616e-04	-8.25	regulation of transport	biological process	GO:0051049	1621	13	18204	49	RIN3,DOCK2,CD74,P2RY6,PLCG2,PRKCD,HIF1A,P2RY2,PTAFR,RHBDF2,PTPN6,SYK,APOE
2.631e-04	-8.24	breast-carcinoma-ER-PR-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-ER-PR-positive_carcinoma	1881	14	16828	45	TLN1,PRKCD,P2RY6,GAB1,NCK1,CSF1R,SYK,VAV1,P2RY2,RIN3,PLCG2,PTPN6,PIK3R5,ELMO1
2.631e-04	-8.24	ER-PR-positive_carcinoma	COSMIC cancer mutations	ER-PR-positive_carcinoma	1881	14	16828	45	PIK3R5,ELMO1,PTPN6,NCK1,CSF1R,GAB1,P2RY6,TLN1,PRKCD,PLCG2,RIN3,P2RY2,VAV1,SYK
2.639e-04	-8.24	regulation of phosphorylation	biological process	GO:0042325	994	10	18204	49	PIK3R5,PRKCD,APOE,SYK,IL6R,NCK1,CSF1R,CD74,PTPN6,PLCG2
2.641e-04	-8.24	PH_12	pfam domains	PF16457	9	2	17795	49	PLCG2,ELMO1
2.683e-04	-8.22	negative regulation of cell activation	biological process	GO:0050866	214	5	18204	49	PRKCD,CD74,APOE,VSIR,PTPN6
2.708e-04	-8.21	TRIM15 (tripartite motif containing 15)	protein interactions	89870	50	3	19454	49	IRF5,SYK,GAB1
2.794e-04	-8.18	CRK (CRK proto-oncogene, adaptor protein)	protein interactions	1398	361	6	19454	49	ELMO1,GAB1,ARAP1,NCK1,RIN3,VAV1
2.804e-04	-8.18	SH3 domain binding	molecular function	GO:0017124	122	4	18094	47	ELMO1,SKAP1,PTPN6,ARHGAP27
2.906e-04	-8.14	defense response to other organism	biological process	GO:0098542	1006	10	18204	49	PRKCD,SYK,IL6R,NCK1,IRF5,CSF1R,ASS1,CD74,PLCG2,PTPN6
3.031e-04	-8.10	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	7	10285	37	TLN1,SYK,ADCY7,PRKCD,PLCG2,GAB1,VAV1
3.089e-04	-8.08	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	20	16828	45	RIN3,PTAFR,GIT2,PLCG2,AKAP13,VAV1,HIF1A,P2RY6,PRKCD,TLN1,CSF1R,ADCY7,PDE11A,WDFY4,ARHGAP15,MYO1F,ARHGAP33,CDH18,ARAP1,DOCK2
3.095e-04	-8.08	regulation of cell adhesion mediated by integrin	biological process	GO:0033628	49	3	18204	49	PTPN6,SYK,SKAP1
3.146e-04	-8.06	regulation of cellular component biogenesis	biological process	GO:0044087	1016	10	18204	49	SEMA4A,SKAP1,SYK,NCK1,PRKCD,TLN1,APOE,PREX1,PLCG2,ARAP1
3.220e-04	-8.04	CLEC7A (C-type lectin domain containing 7A)	protein interactions	64581	53	3	19454	49	VSIR,SYK,CD74
3.223e-04	-8.04	regulation of leukocyte chemotaxis	biological process	GO:0002688	122	4	18204	49	CD74,RIN3,IL6R,CSF1R
3.268e-04	-8.03	signaling receptor binding	molecular function	GO:0005102	1493	12	18094	47	TLN1,SYK,DOCK2,P2RY2,BLNK,CD74,NCK1,ARAP1,APOE,IL6R,SEMA4A,FYB1
3.369e-04	-8.00	LAT2 (linker for activation of T cells family member 2)	protein interactions	7462	11	2	19454	49	PLCG2,GAB1
3.430e-04	-7.98	Interferon gamma signaling	REACTOME pathways	R-HSA-877300	94	4	10285	37	PRKCD,PTAFR,IRF5,PTPN6
3.474e-04	-7.97	regulation of cellular component size	biological process	GO:0032535	352	6	18204	49	VAV1,NCK1,APOE,PRKCD,PREX1,RIN3
3.478e-04	-7.96	Nef and signal transduction	REACTOME pathways	R-HSA-164944	8	2	10285	37	DOCK2,ELMO1
3.491e-04	-7.96	regulation of anatomical structure size	biological process	GO:0090066	498	7	18204	49	PREX1,RIN3,VAV1,P2RY2,NCK1,PRKCD,APOE
3.505e-04	-7.96	positive regulation of cellular biosynthetic process	biological process	GO:0031328	2652	17	18204	49	NCK1,IL6R,VSIR,PRKCD,CSF1R,HIF1A,PTAFR,CD74,P2RY6,PLCG2,SYK,SKAP1,APOE,IRF5,DENND1B,BLNK,SBNO2
3.530e-04	-7.95	Phospholipase D signaling pathway	KEGG pathways	ko04072	145	5	7161	31	GAB1,ADCY7,PLCG2,PIK3R5,SYK
3.530e-04	-7.95	Phospholipase D signaling pathway	KEGG pathways	hsa04072	145	5	7161	31	ADCY7,GAB1,SYK,PIK3R5,PLCG2
3.664e-04	-7.91	positive regulation of transport	biological process	GO:0051050	844	9	18204	49	PLCG2,P2RY6,DOCK2,P2RY2,PTAFR,HIF1A,PRKCD,APOE,SYK
3.731e-04	-7.89	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	49	PRKCD,SKAP1,SYK,CSF1R,PTPN6,PLCG2,GAB1,BLNK
3.738e-04	-7.89	regulation of protein modification process	biological process	GO:0031399	1242	11	18204	49	NCK1,SYK,IL6R,PIK3R5,APOE,PRKCD,CSF1R,HIF1A,CD74,PTPN6,PLCG2
3.790e-04	-7.88	PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)	protein interactions	5294	56	3	19454	49	GAB1,PIK3R5,SYK
3.801e-04	-7.88	regulation of biological quality	biological process	GO:0065008	2936	18	18204	49	PTPN6,ARAP1,ARHGAP33,SEMA4A,SYK,APOE,PLCG2,PREX1,RIN3,VAV1,HIF1A,CSF1R,P2RY2,PTAFR,NCK1,ARHGAP15,TLN1,PRKCD
3.812e-04	-7.87	regulation of leukocyte migration	biological process	GO:0002685	231	5	18204	49	CSF1R,PTAFR,RIN3,IL6R,CD74
3.816e-04	-7.87	BCR Signaling Pathway	SMPDB pathways	SMP0069871	32	3	1369	7	BLNK,SYK,VAV1
3.869e-04	-7.86	positive regulation of protein metabolic process	biological process	GO:0051247	1247	11	18204	49	APOE,PRKCD,PIK3R5,VSIR,IL6R,SYK,NCK1,PTAFR,CSF1R,CD74,PLCG2
3.902e-04	-7.85	MET (MET proto-oncogene, receptor tyrosine kinase)	protein interactions	4233	248	5	19454	49	PLCG2,VAV1,GAB1,NCK1,SYK
3.906e-04	-7.85	regulation of platelet activation	biological process	GO:0010543	53	3	18204	49	SYK,PRKCD,APOE
3.984e-04	-7.83	response to organophosphorus	biological process	GO:0046683	129	4	18204	49	PTAFR,P2RY2,ASS1,P2RY6
3.993e-04	-7.83	ITK (IL2 inducible T cell kinase)	protein interactions	3702	57	3	19454	49	GAB1,BLNK,PLCG2
3.993e-04	-7.83	PRKCQ (protein kinase C theta)	protein interactions	5588	57	3	19454	49	FYB1,VAV1,PRKCD
3.997e-04	-7.82	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	10	18204	49	PRKCD,ADCY7,PTAFR,P2RY2,ASS1,HIF1A,GAB1,PLCG2,SBNO2,P2RY6
4.032e-04	-7.82	positive regulation of leukocyte activation	biological process	GO:0002696	362	6	18204	49	PTPN6,VAV1,CD74,NCK1,SYK,VSIR
4.036e-04	-7.81	RWDD1 (RWD domain containing 1)	protein interactions	51389	12	2	19454	49	CD74,P2RY6
4.092e-04	-7.80	adaptive immune response	biological process	GO:0002250	363	6	18204	49	SKAP1,IL6R,SYK,CD74,PRKCD,SEMA4A
4.110e-04	-7.80	human chr11q13.4	chromosome location	human chr11q13.4	77	3	26134	49	ARAP1,P2RY6,P2RY2
4.128e-04	-7.79	regulation of alcohol biosynthetic process	biological process	GO:1902930	54	3	18204	49	APOE,PTAFR,P2RY6
4.270e-04	-7.76	response to bacterium	biological process	GO:0009617	681	8	18204	49	ASS1,PTAFR,IRF5,IL6R,SYK,PRKCD,SBNO2,PLCG2
4.357e-04	-7.74	neutrophil chemotaxis	biological process	GO:0030593	55	3	18204	49	SYK,PREX1,VAV1
4.577e-04	-7.69	ATG16L1 (autophagy related 16 like 1)	protein interactions	55054	1138	10	19454	49	VAV1,SYK,DOCK2,AKAP13,ARHGAP15,PLCG2,TLN1,ELMO1,GMIP,GIT2
4.578e-04	-7.69	regulation of cytoskeleton organization	biological process	GO:0051493	521	7	18204	49	CSF1R,AKAP13,NCK1,PRKCD,PREX1,CARMIL3,ARAP1
4.605e-04	-7.68	inositol phosphate biosynthetic process	biological process	GO:0032958	12	2	18204	49	PTAFR,PLCG2
4.605e-04	-7.68	negative thymic T cell selection	biological process	GO:0045060	12	2	18204	49	CD74,DOCK2
4.605e-04	-7.68	positive thymic T cell selection	biological process	GO:0045059	12	2	18204	49	DOCK2,CD74
4.695e-04	-7.66	Regulation of RAC1 activity	Pathway Interaction DB	rac1_reg_pathway	39	4	2226	22	PREX1,DOCK2,ELMO1,VAV1
4.763e-04	-7.65	FCRL3 (Fc receptor like 3)	protein interactions	115352	13	2	19454	49	SYK,PTPN6
4.835e-04	-7.63	KDR (kinase insert domain receptor)	protein interactions	3791	145	4	19454	49	NCK1,P2RY2,PLCG2,PTPN6
5.002e-04	-7.60	lymphocyte activation involved in immune response	biological process	GO:0002285	137	4	18204	49	IL6R,CD74,PLCG2,SEMA4A
5.002e-04	-7.60	myeloid leukocyte migration	biological process	GO:0097529	137	4	18204	49	IL6R,SYK,PREX1,VAV1
5.175e-04	-7.57	cellular response to biotic stimulus	biological process	GO:0071216	247	5	18204	49	SYK,PLCG2,PTAFR,SBNO2,ASS1
5.284e-04	-7.55	regulation of cell shape	biological process	GO:0008360	139	4	18204	49	SEMA4A,CSF1R,ARAP1,ARHGAP15
5.284e-04	-7.55	positive regulation of cell activation	biological process	GO:0050867	381	6	18204	49	CD74,VSIR,SYK,NCK1,PTPN6,VAV1
5.284e-04	-7.55	positive regulation of transferase activity	biological process	GO:0051347	381	6	18204	49	PIK3R5,PRKCD,CD74,APOE,IL6R,CSF1R
5.362e-04	-7.53	PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)	protein interactions	55824	63	3	19454	49	PTPN6,VAV1,SYK
5.432e-04	-7.52	positive regulation of inositol phosphate biosynthetic process	biological process	GO:0060732	13	2	18204	49	PTAFR,P2RY6
5.432e-04	-7.52	negative T cell selection	biological process	GO:0043383	13	2	18204	49	DOCK2,CD74
5.507e-04	-7.50	regulation of T cell activation	biological process	GO:0050863	384	6	18204	49	PTPN6,CD74,VAV1,VSIR,SYK,NCK1
5.507e-04	-7.50	cytokine-mediated signaling pathway	biological process	GO:0019221	384	6	18204	49	PTPN6,CD74,CSF1R,IRF5,IL6R,SYK
5.547e-04	-7.50	LYSMD2 (LysM domain containing 2)	protein interactions	256586	14	2	19454	49	HIF1A,PRKCD
5.623e-04	-7.48	C1-like_sf	interpro domains	IPR046349	61	3	18521	49	AKAP13,GMIP,PRKCD
5.726e-04	-7.47	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	4	18204	49	P2RY6,PTAFR,APOE,CD74
5.867e-04	-7.44	regulation of biological process	biological process	GO:0050789	12079	43	18204	49	ARHGAP27,NEK6,P2RY6,GMIP,GAB1,DOCK2,P2RY2,PTAFR,HIF1A,TLN1,VSIR,NCK1,IL6R,ARHGAP15,ELMO1,PTPN6,RHBDF2,BLNK,CARMIL3,FYB1,SKAP1,PLCG2,PREX1,CD74,RIN3,CSF1R,VAV1,PRKCD,ADCY7,AKAP13,GSDME,PDE11A,SBNO2,GIT2,ARAP1,SEMA4A,DENND1B,IRF5,ARHGAP33,ASS1,APOE,PIK3R5,SYK
5.954e-04	-7.43	receptor complex	cellular component	GO:0043235	409	6	19108	49	SKAP1,CD74,CSF1R,PTPN6,SYK,IL6R
6.035e-04	-7.41	response to purine-containing compound	biological process	GO:0014074	144	4	18204	49	PTAFR,P2RY2,ASS1,P2RY6
6.074e-04	-7.41	bone	COSMIC cancer mutations	bone	8157	33	16828	45	ARHGAP15,ASS1,PREX1,MYO1F,ARHGAP27,IRF5,ARHGAP33,RHBDF2,ELMO1,PARVG,PTPN6,CDH18,EHBP1L1,ADCY7,GAB1,WDFY4,P2RY6,PRKCD,TLN1,IPCEF1,DENND1B,DOCK2,ARAP1,AKAP13,PLCG2,RIN3,P2RY2,VAV1,PDE11A,CSF1R,BLNK,HIF1A,GMIP
6.144e-04	-7.39	transport	biological process	GO:0006810	3615	20	18204	49	ARHGAP27,PLCG2,P2RY6,CD74,RIN3,DOCK2,MYO1F,PTAFR,VAV1,HIF1A,IPCEF1,PRKCD,ELMO1,GSDME,RHBDF2,GIT2,ARHGAP33,DENND1B,APOE,SYK
6.199e-04	-7.39	macrophage activation	biological process	GO:0042116	62	3	18204	49	SYK,SBNO2,PLCG2
6.311e-04	-7.37	SH3_2	pfam domains	PF07653	61	3	17795	49	ARHGAP33,FYB1,DOCK2
6.361e-04	-7.36	functioning	COSMIC cancer mutations	functioning	1803	13	16828	45	SKAP1,WDFY4,BLNK,CSF1R,ADCY7,IPCEF1,RIN3,VAV1,ELMO1,SBNO2,PTPN6,DOCK2,CDH18
6.361e-04	-7.36	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	13	16828	45	PTPN6,DOCK2,CDH18,ELMO1,SBNO2,VAV1,RIN3,IPCEF1,BLNK,SKAP1,WDFY4,ADCY7,CSF1R
6.414e-04	-7.35	response to oxygen-containing compound	biological process	GO:1901700	1546	12	18204	49	ADCY7,PRKCD,APOE,HIF1A,ASS1,P2RY2,PTAFR,IRF5,GAB1,SBNO2,P2RY6,PLCG2
6.497e-04	-7.34	regulation of receptor internalization	biological process	GO:0002090	63	3	18204	49	PLCG2,RIN3,SYK
6.521e-04	-7.34	leukocyte chemotaxis	biological process	GO:0030595	147	4	18204	49	VAV1,PREX1,IL6R,SYK
6.689e-04	-7.31	regulation of reactive oxygen species metabolic process	biological process	GO:2000377	148	4	18204	49	HIF1A,PLCG2,SYK,PRKCD
6.803e-04	-7.29	regulation of interleukin-12 production	biological process	GO:0032655	64	3	18204	49	IRF5,PLCG2,SYK
6.860e-04	-7.28	negative regulation of leukocyte cell-cell adhesion	biological process	GO:1903038	149	4	18204	49	VSIR,CD74,ASS1,PTPN6
6.860e-04	-7.28	positive regulation of leukocyte migration	biological process	GO:0002687	149	4	18204	49	PTAFR,CSF1R,CD74,IL6R
7.119e-04	-7.25	regulation of interleukin-10 production	biological process	GO:0032653	65	3	18204	49	PLCG2,SYK,VSIR
7.212e-04	-7.23	positive regulation of leukocyte mediated immunity	biological process	GO:0002705	151	4	18204	49	VAV1,PTAFR,DENND1B,PLCG2
7.236e-04	-7.23	phosphatidylinositol binding	molecular function	GO:0035091	276	5	18094	47	ARHGAP33,TLN1,GSDME,ARAP1,DENND1B
7.288e-04	-7.22	regulation of phospholipid transport	biological process	GO:2001138	15	2	18204	49	APOE,PRKCD
7.288e-04	-7.22	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	2	18204	49	P2RY6,PTAFR
7.292e-04	-7.22	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	2	19454	49	RIN3,APOE
7.301e-04	-7.22	ITGB3 (integrin subunit beta 3)	protein interactions	3690	70	3	19454	49	SYK,P2RY2,TLN1
7.444e-04	-7.20	neutrophil migration	biological process	GO:1990266	66	3	18204	49	VAV1,PREX1,SYK
7.444e-04	-7.20	peptidyl-tyrosine phosphorylation	biological process	GO:0018108	66	3	18204	49	SYK,PTPN6,CSF1R
7.452e-04	-7.20	innate immune response	biological process	GO:0045087	741	8	18204	49	CD74,PTPN6,PLCG2,NCK1,SYK,IRF5,CSF1R,ASS1
7.484e-04	-7.20	regulation of leukocyte proliferation	biological process	GO:0070663	268	5	18204	49	NCK1,VSIR,CD74,CSF1R,PTPN6
7.519e-04	-7.19	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	4	7161	31	PRKCD,PLCG2,P2RY2,ADCY7
7.519e-04	-7.19	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	4	7161	31	ADCY7,P2RY2,PLCG2,PRKCD
7.575e-04	-7.19	leukocyte proliferation	biological process	GO:0070661	153	4	18204	49	PTPN6,CSF1R,PRKCD,DOCK2
7.611e-04	-7.18	regulation of actin filament organization	biological process	GO:0110053	269	5	18204	49	PREX1,CARMIL3,NCK1,PRKCD,ARAP1
7.764e-04	-7.16	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	16	16828	45	MYO1F,ARHGAP33,DOCK2,CDH18,ARAP1,AKAP13,PTAFR,RIN3,PLCG2,P2RY2,VAV1,SYK,ADCY7,GAB1,P2RY6,PRKCD
7.853e-04	-7.15	RASA1 (RAS p21 protein activator 1)	protein interactions	5921	165	4	19454	49	GAB1,NCK1,SYK,CSF1R
7.926e-04	-7.14	ITGB2 (integrin subunit beta 2)	protein interactions	3689	72	3	19454	49	SYK,PRKCD,TLN1
8.098e-04	-7.12	small GTPase binding	molecular function	GO:0031267	283	5	18094	47	DENND1B,AKAP13,GIT2,DOCK2,RIN3
8.122e-04	-7.12	peptidyl-tyrosine modification	biological process	GO:0018212	68	3	18204	49	SYK,PTPN6,CSF1R
8.125e-04	-7.12	P2Y receptors	REACTOME pathways	R-HSA-417957	12	2	10285	37	P2RY6,P2RY2
8.129e-04	-7.11	positive regulation of protein phosphorylation	biological process	GO:0001934	574	7	18204	49	PRKCD,PIK3R5,SYK,IL6R,CSF1R,CD74,PLCG2
8.304e-04	-7.09	CH	pfam domains	PF00307	67	3	17795	49	EHBP1L1,PARVG,VAV1
8.342e-04	-7.09	positive regulation of endocytosis	biological process	GO:0045807	157	4	18204	49	APOE,SYK,DOCK2,PLCG2
8.410e-04	-7.08	DH-domain	interpro domains	IPR000219	70	3	18521	49	PREX1,AKAP13,VAV1
8.510e-04	-7.07	cellular process	biological process	GO:0009987	14996	48	18204	49	PTPN6,ARHGAP15,IL6R,HIF1A,GAB1,P2RY6,PIK3R5,ASS1,IRF5,ARHGAP33,SEMA4A,ARAP1,GSDME,ADCY7,RIN3,CD74,CDH18,PREX1,PLCG2,SKAP1,WDFY4,PARVG,FYB1,CARMIL3,BLNK,RHBDF2,ELMO1,NCK1,VSIR,IPCEF1,TLN1,P2RY2,MYO1F,PTAFR,DOCK2,GMIP,NEK6,ARHGAP27,SYK,APOE,DENND1B,GIT2,PDE11A,SBNO2,AKAP13,PRKCD,VAV1,CSF1R
8.585e-04	-7.06	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	3	19454	49	PLCG2,GAB1,VAV1
8.600e-04	-7.06	TOP3B (DNA topoisomerase III beta)	protein interactions	8940	1465	11	19454	49	ARAP1,ADCY7,RIN3,SBNO2,ARHGAP33,IRF5,AKAP13,PREX1,RHBDF2,TLN1,EHBP1L1
8.693e-04	-7.05	PTK2 (protein tyrosine kinase 2)	protein interactions	5747	296	5	19454	49	PTPN6,NCK1,PTAFR,SYK,TLN1
8.765e-04	-7.04	DBL_dom_sf	interpro domains	IPR035899	71	3	18521	49	PREX1,AKAP13,VAV1
8.822e-04	-7.03	actin filament organization	biological process	GO:0007015	278	5	18204	49	ELMO1,MYO1F,PREX1,ARAP1,NCK1
8.838e-04	-7.03	positive regulation of reactive oxygen species metabolic process	biological process	GO:2000379	70	3	18204	49	PRKCD,SYK,PLCG2
8.939e-04	-7.02	positive regulation of protein modification process	biological process	GO:0031401	762	8	18204	49	PRKCD,PIK3R5,IL6R,SYK,NCK1,CSF1R,CD74,PLCG2
9.434e-04	-6.97	RhoGEF	pfam domains	PF00621	70	3	17795	49	PREX1,VAV1,AKAP13
9.566e-04	-6.95	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	18	18204	49	PLCG2,P2RY6,CD74,PTAFR,HIF1A,CSF1R,PRKCD,NCK1,IL6R,VSIR,SBNO2,BLNK,IRF5,DENND1B,PIK3R5,APOE,SYK,SKAP1
9.571e-04	-6.95	NME2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	4831	174	4	19454	49	AKAP13,PLCG2,GIT2,PREX1
9.581e-04	-6.95	Signal regulatory protein (SIRP) family interactions	REACTOME pathways	R-HSA-391160	13	2	10285	37	FYB1,PTPN6
9.696e-04	-6.94	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	6	18204	49	CSF1R,VAV1,NCK1,SYK,BLNK,GAB1
9.696e-04	-6.94	negative regulation of response to external stimulus	biological process	GO:0032102	428	6	18204	49	RIN3,RHBDF2,PTPN6,SYK,APOE,PRKCD
1.002e-03	-6.91	G protein-coupled receptor signaling pathway	biological process	GO:0007186	1178	10	18204	49	ADCY7,AKAP13,PIK3R5,APOE,VAV1,P2RY2,PTAFR,P2RY6,PTPN6,PREX1
1.005e-03	-6.90	response to wounding	biological process	GO:0009611	431	6	18204	49	SYK,TLN1,VAV1,HIF1A,PTPN6,PLCG2
1.043e-03	-6.87	negative regulation of intracellular signal transduction	biological process	GO:1902532	599	7	18204	49	CD74,PTPN6,PDE11A,APOE,PRKCD,NCK1,HIF1A
1.056e-03	-6.85	negative regulation of platelet activation	biological process	GO:0010544	18	2	18204	49	PRKCD,APOE
1.056e-03	-6.85	positive regulation of superoxide anion generation	biological process	GO:0032930	18	2	18204	49	SYK,PRKCD
1.056e-03	-6.85	positive regulation of type 2 immune response	biological process	GO:0002830	18	2	18204	49	DENND1B,CD74
1.080e-03	-6.83	positive regulation of type I interferon production	biological process	GO:0032481	75	3	18204	49	IRF5,PLCG2,SYK
1.105e-03	-6.81	regulation of secretion	biological process	GO:0051046	605	7	18204	49	RHBDF2,CD74,HIF1A,PTAFR,P2RY2,SYK,APOE
1.115e-03	-6.80	negative regulation of defense response	biological process	GO:0031348	293	5	18204	49	RHBDF2,PTPN6,SYK,APOE,PRKCD
1.122e-03	-6.79	alpha-beta T cell differentiation	biological process	GO:0046632	76	3	18204	49	SYK,IL6R,SEMA4A
1.150e-03	-6.77	regulation of endocytosis	biological process	GO:0030100	295	5	18204	49	PLCG2,APOE,SYK,RIN3,DOCK2
1.154e-03	-6.76	SORBS3 (sorbin and SH3 domain containing 3)	protein interactions	10174	183	4	19454	49	NCK1,ARAP1,NEK6,RIN3
1.154e-03	-6.76	HCK (HCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3055	183	4	19454	49	PLCG2,VAV1,GAB1,ELMO1
1.174e-03	-6.75	positive regulation of metabolic process	biological process	GO:0009893	3796	20	18204	49	NCK1,IL6R,VSIR,PRKCD,CSF1R,HIF1A,PTAFR,CD74,P2RY6,PLCG2,SYK,SKAP1,PIK3R5,APOE,ASS1,IRF5,DENND1B,ARAP1,BLNK,SBNO2
1.196e-03	-6.73	regulation of smooth muscle cell proliferation	biological process	GO:0048660	173	4	18204	49	P2RY6,PTAFR,IL6R,APOE
1.234e-03	-6.70	Nucleotide GPCRs	WikiPathways	WP80	11	2	5310	26	P2RY6,P2RY2
1.239e-03	-6.69	regulation of epithelial cell migration	biological process	GO:0010632	300	5	18204	49	HIF1A,PLCG2,SEMA4A,APOE,GAB1
1.247e-03	-6.69	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	5	19454	49	HIF1A,EHBP1L1,PRKCD,VAV1,TLN1
1.261e-03	-6.68	positive regulation of phosphorylation	biological process	GO:0042327	619	7	18204	49	PLCG2,CD74,CSF1R,IL6R,SYK,PRKCD,PIK3R5
1.267e-03	-6.67	Innate Immune System	REACTOME pathways	R-HSA-168249	1285	12	10285	37	NCK1,GAB1,PTPN6,DOCK2,PLCG2,PRKCD,ELMO1,VAV1,ADCY7,SYK,TLN1,PTAFR
1.268e-03	-6.67	Cell-Cell communication	REACTOME pathways	R-HSA-1500931	133	4	10285	37	NCK1,FYB1,PTPN6,CDH18
1.274e-03	-6.67	NRAGE signals death through JNK	REACTOME pathways	R-HSA-193648	60	3	10285	37	PREX1,AKAP13,VAV1
1.274e-03	-6.67	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002460	176	4	18204	49	CD74,PRKCD,IL6R,SEMA4A
1.276e-03	-6.66	positive regulation of kinase activity	biological process	GO:0033674	302	5	18204	49	CSF1R,IL6R,PIK3R5,PRKCD,CD74
1.284e-03	-6.66	CH_dom	interpro domains	IPR001715	81	3	18521	49	PARVG,EHBP1L1,VAV1
1.306e-03	-6.64	GTPase binding	molecular function	GO:0051020	315	5	18094	47	RIN3,AKAP13,GIT2,DENND1B,DOCK2
1.331e-03	-6.62	CH_dom_sf	interpro domains	IPR036872	82	3	18521	49	PARVG,EHBP1L1,VAV1
1.353e-03	-6.61	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	7	10285	37	GAB1,PREX1,VAV1,AKAP13,TLN1,PRKCD,ADCY7
1.390e-03	-6.58	FCGR2B (Fc gamma receptor IIb)	protein interactions	2213	22	2	19454	49	GAB1,PTPN6
1.394e-03	-6.58	GDS_CDC24_CS	interpro domains	IPR001331	21	2	18521	49	VAV1,PREX1
1.398e-03	-6.57	granulocyte chemotaxis	biological process	GO:0071621	82	3	18204	49	VAV1,PREX1,SYK
1.398e-03	-6.57	T cell activation involved in immune response	biological process	GO:0002286	82	3	18204	49	SEMA4A,CD74,IL6R
1.412e-03	-6.56	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	24	16828	45	CSF1R,NCK1,PDE11A,GAB1,WDFY4,HIF1A,TLN1,PRKCD,VAV1,SEMA4A,SYK,AKAP13,PLCG2,GIT2,PTPN6,CDH18,ARAP1,ARHGAP33,PIK3R5,IL6R,PREX1,IRF5,ARHGAP15,NEK6
1.412e-03	-6.56	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	24	16828	45	PRKCD,TLN1,GAB1,WDFY4,GIT2,SEMA4A,SYK,ARHGAP33,PIK3R5,CDH18,PTPN6,ARHGAP15,NEK6,IRF5,PREX1,HIF1A,CSF1R,NCK1,PDE11A,PLCG2,AKAP13,VAV1,ARAP1,IL6R
1.432e-03	-6.55	negative regulation of cell adhesion	biological process	GO:0007162	310	5	18204	49	PTPN6,ASS1,PRKCD,CD74,VSIR
1.442e-03	-6.54	regulation of cytokine-mediated signaling pathway	biological process	GO:0001959	182	4	18204	49	CD74,SYK,PTPN6,HIF1A
1.443e-03	-6.54	plasma membrane signaling receptor complex	cellular component	GO:0098802	191	4	19108	49	SKAP1,IL6R,PTPN6,SYK
1.443e-03	-6.54	regulation of superoxide anion generation	biological process	GO:0032928	21	2	18204	49	PRKCD,SYK
1.443e-03	-6.54	thymic T cell selection	biological process	GO:0045061	21	2	18204	49	DOCK2,CD74
1.443e-03	-6.54	positive regulation by host of viral process	biological process	GO:0044794	21	2	18204	49	CSF1R,APOE
1.450e-03	-6.54	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	29	16828	45	DENND1B,ARAP1,DOCK2,SBNO2,P2RY2,RIN3,PLCG2,AKAP13,GMIP,NCK1,PDE11A,CSF1R,IRF5,MYO1F,PREX1,NEK6,CDH18,PTPN6,PARVG,RHBDF2,ARHGAP33,ELMO1,SYK,EHBP1L1,GIT2,TLN1,PRKCD,GAB1,WDFY4
1.458e-03	-6.53	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	6	10285	37	GAB1,NCK1,VAV1,TLN1,ADCY7,PRKCD
1.464e-03	-6.53	Nucleotide-like (purinergic) receptors	REACTOME pathways	R-HSA-418038	16	2	10285	37	P2RY6,P2RY2
1.472e-03	-6.52	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	39	16828	45	ARAP1,DOCK2,RIN3,PLCG2,AKAP13,VAV1,P2RY2,HIF1A,BLNK,PDE11A,NCK1,CSF1R,GMIP,NEK6,ASS1,ARHGAP15,MYO1F,IRF5,CD74,PREX1,ELMO1,PIK3R5,RHBDF2,ARHGAP33,CDH18,PTPN6,PARVG,GIT2,PTAFR,SYK,EHBP1L1,TLN1,PRKCD,P2RY6,WDFY4,GAB1,SKAP1,ADCY7,IPCEF1
1.489e-03	-6.51	localization	biological process	GO:0051179	4474	22	18204	49	P2RY6,PLCG2,ARHGAP27,DOCK2,RIN3,CD74,VAV1,HIF1A,PTAFR,MYO1F,PRKCD,IPCEF1,RHBDF2,GIT2,ELMO1,GSDME,FYB1,ARHGAP33,DENND1B,SYK,SKAP1,APOE
1.506e-03	-6.50	MTOR (mechanistic target of rapamycin kinase)	protein interactions	2475	335	5	19454	49	PRKCD,PREX1,CD74,P2RY6,HIF1A
1.514e-03	-6.49	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	4	19454	49	NCK1,GAB1,SKAP1,IL6R
1.521e-03	-6.49	lung-carcinoma	COSMIC cancer mutations	lung-carcinoma	4255	21	16828	45	AKAP13,GIT2,PLCG2,VAV1,SEMA4A,SYK,PDE11A,CSF1R,NCK1,GAB1,HIF1A,PRKCD,TLN1,ARHGAP15,NEK6,IL6R,PREX1,IRF5,ARHGAP33,PIK3R5,PTPN6
1.542e-03	-6.47	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	7	16828	45	SYK,RIN3,NEK6,PRKCD,ADCY7,RHBDF2,CSF1R
1.573e-03	-6.46	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	3	14470	47	VAV1,AKAP13,PREX1
1.581e-03	-6.45	cytoskeleton organization	biological process	GO:0007010	1251	10	18204	49	MYO1F,PARVG,NCK1,APOE,TLN1,NEK6,PREX1,ELMO1,DOCK2,ARAP1
1.595e-03	-6.44	establishment of localization	biological process	GO:0051234	3887	20	18204	49	CD74,RIN3,DOCK2,PLCG2,ARHGAP27,P2RY6,IPCEF1,PRKCD,MYO1F,PTAFR,VAV1,HIF1A,ELMO1,GSDME,GIT2,RHBDF2,APOE,SYK,ARHGAP33,DENND1B
1.614e-03	-6.43	phospholipase binding	molecular function	GO:0043274	23	2	18094	47	SYK,BLNK
1.637e-03	-6.41	PDGFR-beta signaling pathway	Pathway Interaction DB	pdgfrbpathway	54	4	2226	22	NCK1,GAB1,HIF1A,PRKCD
1.653e-03	-6.41	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	31	16828	45	AKAP13,RIN3,VAV1,BLNK,PDE11A,CSF1R,HIF1A,GMIP,DENND1B,SBNO2,DOCK2,GIT2,APOE,SYK,SKAP1,WDFY4,GAB1,ADCY7,PRKCD,TLN1,IPCEF1,ASS1,NEK6,ARHGAP15,PREX1,MYO1F,ARHGAP27,PIK3R5,ELMO1,ARHGAP33,PARVG
1.654e-03	-6.40	IL-3 Signaling Pathway	WikiPathways	WP286	49	3	5310	26	VAV1,SYK,PTPN6
1.656e-03	-6.40	regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001242	189	4	18204	49	NCK1,CD74,HIF1A,GSDME
1.656e-03	-6.40	B cell activation	biological process	GO:0042113	189	4	18204	49	SYK,PRKCD,BLNK,PLCG2
1.675e-03	-6.39	EGF receptor (ErbB1) signaling pathway	Pathway Interaction DB	erbb1_receptor_proximal_pathway	25	3	2226	22	TLN1,PTPN6,GAB1
1.707e-03	-6.37	regulation of defense response	biological process	GO:0031347	843	8	18204	49	RHBDF2,SBNO2,PTPN6,PLCG2,SYK,PRKCD,APOE,VAV1
1.732e-03	-6.36	stimulatory C-type lectin receptor signaling pathway	biological process	GO:0002223	23	2	18204	49	SYK,PLCG2
1.732e-03	-6.36	cellular response to lectin	biological process	GO:1990858	23	2	18204	49	SYK,PLCG2
1.732e-03	-6.36	response to lectin	biological process	GO:1990840	23	2	18204	49	PLCG2,SYK
1.738e-03	-6.35	biological regulation	biological process	GO:0065007	12501	43	18204	49	AKAP13,PRKCD,VAV1,CSF1R,SYK,APOE,DENND1B,GIT2,PDE11A,SBNO2,NCK1,VSIR,TLN1,P2RY2,PTAFR,DOCK2,GMIP,NEK6,ARHGAP27,SKAP1,FYB1,CARMIL3,BLNK,RHBDF2,ELMO1,ADCY7,RIN3,CD74,PREX1,PLCG2,PIK3R5,ASS1,ARHGAP33,IRF5,SEMA4A,ARAP1,GSDME,IL6R,ARHGAP15,HIF1A,GAB1,P2RY6,PTPN6
1.752e-03	-6.35	Signaling by PTK6	REACTOME pathways	R-HSA-8848021	67	3	10285	37	HIF1A,ELMO1,ARAP1
1.758e-03	-6.34	cell development	biological process	GO:0048468	2236	14	18204	49	APOE,SYK,SEMA4A,BLNK,PTPN6,SBNO2,IL6R,HIF1A,CSF1R,VAV1,CD74,DOCK2,PREX1,PLCG2
1.769e-03	-6.34	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	3	18204	49	PRKCD,CD74,APOE
1.790e-03	-6.33	brainstem	COSMIC cancer mutations	brainstem	3102	17	16828	45	ARHGAP15,ARHGAP27,PREX1,ELMO1,CDH18,DOCK2,PTPN6,GIT2,AKAP13,VAV1,NCK1,CSF1R,PDE11A,SKAP1,BLNK,WDFY4,GAB1
1.791e-03	-6.33	GPCR downstream signaling	REACTOME pathways	R-HSA-388396	974	10	10285	37	AKAP13,VAV1,P2RY6,PREX1,PDE11A,PIK3R5,PRKCD,ADCY7,PTAFR,P2RY2
1.822e-03	-6.31	regulation of response to cytokine stimulus	biological process	GO:0060759	194	4	18204	49	PTPN6,HIF1A,CD74,SYK
1.855e-03	-6.29	Adaptive Immune System	REACTOME pathways	R-HSA-1280218	810	9	10285	37	FYB1,CD74,SYK,PLCG2,GAB1,PTPN6,BLNK,NCK1,VAV1
1.856e-03	-6.29	multicellular organismal process	biological process	GO:0032501	6177	27	18204	49	AKAP13,ADCY7,PRKCD,CSF1R,VAV1,CD74,CDH18,PREX1,PLCG2,SYK,APOE,ASS1,SEMA4A,SBNO2,GIT2,GSDME,IL6R,NCK1,TLN1,HIF1A,PTAFR,P2RY2,DOCK2,GAB1,WDFY4,BLNK,PTPN6
1.875e-03	-6.28	human chr2q22.2-q22.3	chromosome location	human chr2q22.2-q22.3	1	1	26134	49	ARHGAP15
1.875e-03	-6.28	human chr7p14.2-p14.1	chromosome location	human chr7p14.2-p14.1	1	1	26134	49	ELMO1
1.886e-03	-6.27	Rap1 signaling pathway	KEGG pathways	hsa04015	210	5	7161	31	SKAP1,ADCY7,FYB1,CSF1R,TLN1
1.886e-03	-6.27	Rap1 signaling pathway	KEGG pathways	ko04015	210	5	7161	31	FYB1,ADCY7,SKAP1,TLN1,CSF1R
1.886e-03	-6.27	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	13	16828	45	SYK,VAV1,P2RY2,PLCG2,RIN3,PRKCD,TLN1,P2RY6,GAB1,CSF1R,NCK1,PTPN6,PIK3R5
1.886e-03	-6.27	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	13	16828	45	SYK,VAV1,P2RY2,PLCG2,RIN3,PRKCD,TLN1,P2RY6,GAB1,CSF1R,NCK1,PTPN6,PIK3R5
1.886e-03	-6.27	positive regulation of macrophage cytokine production	biological process	GO:0060907	24	2	18204	49	PLCG2,CD74
1.909e-03	-6.26	regulation of small molecule metabolic process	biological process	GO:0062012	331	5	18204	49	HIF1A,P2RY6,PTAFR,APOE,CD74
1.945e-03	-6.24	positive regulation of leukocyte chemotaxis	biological process	GO:0002690	92	3	18204	49	CSF1R,CD74,IL6R
1.974e-03	-6.23	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	19	16828	45	IL6R,PREX1,IRF5,NEK6,ARHGAP15,PTPN6,PIK3R5,ARHGAP33,VAV1,SYK,SEMA4A,AKAP13,PLCG2,GIT2,GAB1,NCK1,CSF1R,PRKCD,HIF1A
1.999e-03	-6.22	positive regulation of protein-containing complex assembly	biological process	GO:0031334	199	4	18204	49	NCK1,SYK,SKAP1,PLCG2
1.999e-03	-6.22	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	4	18204	49	CD74,APOE,P2RY6,CSF1R
2.014e-03	-6.21	KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1)	protein interactions	10657	358	5	19454	49	PLCG2,PTPN6,DOCK2,NCK1,VAV1
2.031e-03	-6.20	DH_2	prosite domains	PS50010	70	3	12186	44	AKAP13,PREX1,VAV1
2.040e-03	-6.19	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	6	10285	37	ADCY7,PRKCD,VAV1,NCK1,TLN1,GAB1
2.066e-03	-6.18	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	27	16828	45	PDE11A,CSF1R,VAV1,P2RY2,PLCG2,AKAP13,ARAP1,DOCK2,IPCEF1,TLN1,PRKCD,P2RY6,WDFY4,SKAP1,ADCY7,SYK,PTAFR,CDH18,PARVG,ELMO1,ARHGAP33,MYO1F,IRF5,PREX1,ASS1,NEK6,ARHGAP15
2.066e-03	-6.18	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	27	16828	45	MYO1F,IRF5,PREX1,NEK6,ASS1,ARHGAP15,CDH18,PARVG,ELMO1,ARHGAP33,SYK,PTAFR,IPCEF1,PRKCD,TLN1,P2RY6,SKAP1,WDFY4,ADCY7,ARAP1,DOCK2,VAV1,P2RY2,PLCG2,AKAP13,CSF1R,PDE11A
2.095e-03	-6.17	SLC35B1 (solute carrier family 35 member B1)	protein interactions	10237	27	2	19454	49	CD74,VSIR
2.095e-03	-6.17	OLIG1 (oligodendrocyte transcription factor 1)	protein interactions	116448	27	2	19454	49	PTPN6,NCK1
2.114e-03	-6.16	PSMD3 (proteasome 26S subunit, non-ATPase 3)	protein interactions	5709	362	5	19454	49	RIN3,CD74,P2RY6,PTPN6,PLCG2
2.137e-03	-6.15	Calponin-like domain	gene3d domains	1.10.418.10	79	3	14470	47	PARVG,EHBP1L1,VAV1
2.169e-03	-6.13	Osteoclast differentiation	KEGG pathways	ko04380	129	4	7161	31	CSF1R,BLNK,SYK,PLCG2
2.169e-03	-6.13	Osteoclast differentiation	KEGG pathways	hsa04380	129	4	7161	31	CSF1R,BLNK,SYK,PLCG2
2.174e-03	-6.13	regulation of localization	biological process	GO:0032879	2028	13	18204	49	RIN3,DOCK2,CD74,P2RY6,PLCG2,PRKCD,HIF1A,P2RY2,PTAFR,RHBDF2,PTPN6,SYK,APOE
2.191e-03	-6.12	ErbB Signaling Pathway	WikiPathways	WP673	54	3	5310	26	NCK1,GAB1,PIK3R5
2.197e-03	-6.12	negative regulation of response to wounding	biological process	GO:1903035	96	3	18204	49	PTPN6,APOE,PRKCD
2.197e-03	-6.12	granulocyte migration	biological process	GO:0097530	96	3	18204	49	SYK,VAV1,PREX1
2.214e-03	-6.11	positive regulation of alcohol biosynthetic process	biological process	GO:1902932	26	2	18204	49	PTAFR,P2RY6
2.250e-03	-6.10	regulation of lymphocyte activation	biological process	GO:0051249	505	6	18204	49	CD74,PTPN6,SYK,NCK1,VSIR,VAV1
2.250e-03	-6.10	cellular response to organonitrogen compound	biological process	GO:0071417	505	6	18204	49	GAB1,PRKCD,P2RY6,ASS1,P2RY2,PTAFR
2.297e-03	-6.08	CH	smart domains	SM00033	66	3	9717	39	EHBP1L1,PARVG,VAV1
2.307e-03	-6.07	ARFGAP/RecO	interpro domains	IPR037278	27	2	18521	49	ARAP1,GIT2
2.307e-03	-6.07	ArfGAP_dom_sf	interpro domains	IPR038508	27	2	18521	49	GIT2,ARAP1
2.307e-03	-6.07	ArfGAP_dom	interpro domains	IPR001164	27	2	18521	49	ARAP1,GIT2
2.347e-03	-6.05	cellular response to lipopolysaccharide	biological process	GO:0071222	208	4	18204	49	PLCG2,PTAFR,ASS1,SBNO2
2.359e-03	-6.05	Natural killer cell mediated cytotoxicity	KEGG pathways	hsa04650	132	4	7161	31	PLCG2,SYK,PTPN6,VAV1
2.359e-03	-6.05	Natural killer cell mediated cytotoxicity	KEGG pathways	ko04650	132	4	7161	31	VAV1,PTPN6,PLCG2,SYK
2.387e-03	-6.04	positive regulation of receptor internalization	biological process	GO:0002092	27	2	18204	49	PLCG2,SYK
2.387e-03	-6.04	cytokine production	biological process	GO:0001816	27	2	18204	49	HIF1A,IL6R
2.388e-03	-6.04	regulation of adaptive immune response	biological process	GO:0002819	209	4	18204	49	ADCY7,SKAP1,PTPN6,DENND1B
2.388e-03	-6.04	regulation of chemotaxis	biological process	GO:0050920	209	4	18204	49	CSF1R,CD74,RIN3,IL6R
2.391e-03	-6.04	seminoma	COSMIC cancer mutations	seminoma	700	7	16828	45	ADCY7,CSF1R,RHBDF2,PRKCD,SYK,RIN3,NEK6
2.416e-03	-6.03	CNTF (ciliary neurotrophic factor)	protein interactions	1270	29	2	19454	49	APOE,IL6R
2.416e-03	-6.03	CD5 (CD5 molecule)	protein interactions	921	29	2	19454	49	VAV1,PTPN6
2.427e-03	-6.02	TCR signaling in naive CD4+ T cells	Pathway Interaction DB	tcr_pathway	60	4	2226	22	PTPN6,NCK1,VAV1,FYB1
2.466e-03	-6.01	defense response to symbiont	biological process	GO:0140546	894	8	18204	49	SYK,NCK1,IRF5,ASS1,CSF1R,CD74,PTPN6,PLCG2
2.467e-03	-6.00	positive regulation of smooth muscle cell proliferation	biological process	GO:0048661	100	3	18204	49	PTAFR,P2RY6,IL6R
2.472e-03	-6.00	positive regulation of GTPase activity	biological process	GO:0043547	211	4	18204	49	GMIP,ARHGAP27,PREX1,ARAP1
2.480e-03	-6.00	RPL39 (ribosomal protein L39)	protein interactions	6170	107	3	19454	49	SYK,PTPN6,P2RY6
2.480e-03	-6.00	TPP2 (tripeptidyl peptidase 2)	protein interactions	7174	107	3	19454	49	P2RY6,CD74,RIN3
2.482e-03	-6.00	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	6	18204	49	PLCG2,ARAP1,SEMA4A,SKAP1,NCK1,SYK
2.495e-03	-5.99	ArfGap	pfam domains	PF01412	27	2	17795	49	GIT2,ARAP1
2.495e-03	-5.99	PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)	protein interactions	5296	226	4	19454	49	SYK,SKAP1,GAB1,CSF1R
2.502e-03	-5.99	RhoGEF	smart domains	SM00325	68	3	9717	39	AKAP13,VAV1,PREX1
2.506e-03	-5.99	regulation of vesicle-mediated transport	biological process	GO:0060627	516	6	18204	49	PTAFR,APOE,SYK,PLCG2,DOCK2,RIN3
2.515e-03	-5.99	Cell death signalling via NRAGE, NRIF and NADE	REACTOME pathways	R-HSA-204998	76	3	10285	37	PREX1,AKAP13,VAV1
2.519e-03	-5.98	Prkch (protein kinase C, eta)	protein interactions	81749	1	1	19454	49	AKAP13
2.519e-03	-5.98	RPL26P32 (ribosomal protein L26 pseudogene 32)	protein interactions	400055	1	1	19454	49	RIN3
2.519e-03	-5.98	FDPSP4 (farnesyl diphosphate synthase pseudogene 4)	protein interactions	2228	1	1	19454	49	RIN3
2.519e-03	-5.98	Bmal1 (basic helix-loop-helix ARNT like 1)	protein interactions	11865	1	1	19454	49	HIF1A
2.541e-03	-5.98	positive regulation of macromolecule biosynthetic process	biological process	GO:0010557	2592	15	18204	49	CD74,PLCG2,VSIR,IL6R,NCK1,CSF1R,HIF1A,PTAFR,BLNK,SBNO2,SKAP1,SYK,APOE,DENND1B,IRF5
2.556e-03	-5.97	response to molecule of bacterial origin	biological process	GO:0002237	354	5	18204	49	ASS1,SBNO2,PLCG2,PTAFR,IRF5
2.562e-03	-5.97	DH_1	prosite domains	PS00741	21	2	12186	44	VAV1,PREX1
2.564e-03	-5.97	NOS2-CD74 complex	cellular component	GO:0035693	1	1	19108	49	CD74
2.584e-03	-5.96	CSF3R (colony stimulating factor 3 receptor)	protein interactions	1441	30	2	19454	49	SYK,PRKCD
2.594e-03	-5.95	VEGFR1 specific signals	Pathway Interaction DB	vegfr1_pathway	29	3	2226	22	GAB1,NCK1,HIF1A
2.598e-03	-5.95	argininosuccinate synthase activity	molecular function	GO:0004055	1	1	18094	47	ASS1
2.598e-03	-5.95	MHC class II protein binding, via antigen binding groove	molecular function	GO:0042658	1	1	18094	47	CD74
2.598e-03	-5.95	interleukin-15 receptor binding	molecular function	GO:0016170	1	1	18094	47	SYK
2.598e-03	-5.95	metal chelating activity	molecular function	GO:0046911	1	1	18094	47	APOE
2.598e-03	-5.95	ciliary neurotrophic factor binding	molecular function	GO:0070119	1	1	18094	47	IL6R
2.610e-03	-5.95	regulation of phagocytosis	biological process	GO:0050764	102	3	18204	49	SYK,DOCK2,PLCG2
2.614e-03	-5.95	MBP (myelin basic protein)	protein interactions	4155	109	3	19454	49	PTAFR,NCK1,PRKCD
2.624e-03	-5.94	tube development	biological process	GO:0035295	903	8	18204	49	GAB1,PTPN6,APOE,SYK,SEMA4A,CSF1R,ASS1,HIF1A
2.646e-03	-5.93	Arginosuc_synth	interpro domains	IPR001518	1	1	18521	49	ASS1
2.646e-03	-5.93	Arginosuc_syn_N	interpro domains	IPR048267	1	1	18521	49	ASS1
2.646e-03	-5.93	nPKC_delta	interpro domains	IPR034667	1	1	18521	49	PRKCD
2.646e-03	-5.93	CD74_antigen	interpro domains	IPR043530	1	1	18521	49	CD74
2.646e-03	-5.93	SKAP1_SH3	interpro domains	IPR035765	1	1	18521	49	SKAP1
2.646e-03	-5.93	PKC_delta	interpro domains	IPR027436	1	1	18521	49	PRKCD
2.646e-03	-5.93	Arginosuc_syn_C	interpro domains	IPR048268	1	1	18521	49	ASS1
2.646e-03	-5.93	P2Y6_rcpt	interpro domains	IPR001973	1	1	18521	49	P2RY6
2.646e-03	-5.93	VAV1_SH3_2	interpro domains	IPR035729	1	1	18521	49	VAV1
2.646e-03	-5.93	VAV1_SH2	interpro domains	IPR035879	1	1	18521	49	VAV1
2.646e-03	-5.93	Arginosuc_synth_type_1_subfam	interpro domains	IPR023434	1	1	18521	49	ASS1
2.646e-03	-5.93	DHR2_DOCK2	interpro domains	IPR026799	1	1	18521	49	DOCK2
2.646e-03	-5.93	Nck1_SH2	interpro domains	IPR035882	1	1	18521	49	NCK1
2.646e-03	-5.93	CSF-1_receptor	interpro domains	IPR030658	1	1	18521	49	CSF1R
2.646e-03	-5.93	HIF-1_alpha	interpro domains	IPR001321	1	1	18521	49	HIF1A
2.646e-03	-5.93	MHC_II-assoc_invar/CLIP_MHC-bd	interpro domains	IPR015386	1	1	18521	49	CD74
2.646e-03	-5.93	RIN3_SH2	interpro domains	IPR035869	1	1	18521	49	RIN3
2.646e-03	-5.93	AS_cat/multimer_dom_body	interpro domains	IPR024074	1	1	18521	49	ASS1
2.646e-03	-5.93	VISTA	interpro domains	IPR042473	1	1	18521	49	VSIR
2.646e-03	-5.93	Nck1_SH3_2	interpro domains	IPR035564	1	1	18521	49	NCK1
2.646e-03	-5.93	P2Y2_rcpt	interpro domains	IPR000356	1	1	18521	49	P2RY2
2.646e-03	-5.93	Arginosuc_synth_CS	interpro domains	IPR018223	1	1	18521	49	ASS1
2.646e-03	-5.93	MHCII_invariant_trimer_sf	interpro domains	IPR036613	1	1	18521	49	CD74
2.646e-03	-5.93	PAF_rcpt	interpro domains	IPR002282	1	1	18521	49	PTAFR
2.646e-03	-5.93	MHC_II-assoc_invariant_trimer	interpro domains	IPR011988	1	1	18521	49	CD74
2.646e-03	-5.93	PLCgamma2_SH3	interpro domains	IPR035723	1	1	18521	49	PLCG2
2.646e-03	-5.93	MHC_II-assoc_invar_chain	interpro domains	IPR022339	1	1	18521	49	CD74
2.646e-03	-5.93	FYB_hSH3	interpro domains	IPR035540	1	1	18521	49	FYB1
2.646e-03	-5.93	VAV1_SH3_1	interpro domains	IPR035730	1	1	18521	49	VAV1
2.646e-03	-5.93	Nck1_SH3_1	interpro domains	IPR035562	1	1	18521	49	NCK1
2.646e-03	-5.93	Nck1_SH3_3	interpro domains	IPR035565	1	1	18521	49	NCK1
2.675e-03	-5.92	Interleukin-3, 5 and GM-CSF signaling	REACTOME pathways	R-HSA-512988	271	5	10285	37	PTPN6,TLN1,SYK,VAV1,BLNK
2.690e-03	-5.92	regulation of lymphocyte differentiation	biological process	GO:0045619	216	4	18204	49	CD74,SYK,VSIR,PTPN6
2.692e-03	-5.92	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of glucosylceramide catabolic process	biological process	GO:2000753	1	1	18204	49	PRKCD
2.692e-03	-5.92	regulation of maternal process involved in parturition	biological process	GO:1904301	1	1	18204	49	PTAFR
2.692e-03	-5.92	cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	biological process	GO:1904317	1	1	18204	49	PTAFR
2.692e-03	-5.92	positive regulation of phospholipid scramblase activity	biological process	GO:1900163	1	1	18204	49	PRKCD
2.692e-03	-5.92	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	49	APOE
2.692e-03	-5.92	negative regulation of mast cell chemotaxis	biological process	GO:0060755	1	1	18204	49	RIN3
2.692e-03	-5.92	cellular response to gravity	biological process	GO:0071258	1	1	18204	49	PTAFR
2.692e-03	-5.92	regulation of phospholipid scramblase activity	biological process	GO:1900161	1	1	18204	49	PRKCD
2.692e-03	-5.92	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of cap-dependent translational initiation	biological process	GO:1903676	1	1	18204	49	NCK1
2.692e-03	-5.92	regulation of cap-dependent translational initiation	biological process	GO:1903674	1	1	18204	49	NCK1
2.692e-03	-5.92	positive regulation of interleukin-3 production	biological process	GO:0032752	1	1	18204	49	SYK
2.692e-03	-5.92	response to pyrimidine ribonucleotide	biological process	GO:1905834	1	1	18204	49	P2RY6
2.692e-03	-5.92	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of maternal process involved in parturition	biological process	GO:1904303	1	1	18204	49	PTAFR
2.692e-03	-5.92	response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	biological process	GO:1904316	1	1	18204	49	PTAFR
2.692e-03	-5.92	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	49	APOE
2.692e-03	-5.92	argininosuccinate metabolic process	biological process	GO:0000053	1	1	18204	49	ASS1
2.692e-03	-5.92	cellular response to interleukin-11	biological process	GO:0071348	1	1	18204	49	SBNO2
2.692e-03	-5.92	cellular response to pyrimidine ribonucleotide	biological process	GO:1905835	1	1	18204	49	P2RY6
2.692e-03	-5.92	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of collagen catabolic process	biological process	GO:0120158	1	1	18204	49	VSIR
2.692e-03	-5.92	macrophage migration inhibitory factor signaling pathway	biological process	GO:0035691	1	1	18204	49	CD74
2.731e-03	-5.90	positive regulation of cellular component organization	biological process	GO:0051130	1122	9	18204	49	HIF1A,SEMA4A,SYK,NCK1,SKAP1,APOE,PLCG2,DOCK2,ARAP1
2.743e-03	-5.90	PRPS2 (phosphoribosyl pyrophosphate synthetase 2)	protein interactions	5634	232	4	19454	49	NCK1,RIN3,VAV1,GMIP
2.751e-03	-5.90	inositol phosphate metabolic process	biological process	GO:0043647	29	2	18204	49	PTAFR,PLCG2
2.751e-03	-5.90	regulation of platelet aggregation	biological process	GO:0090330	29	2	18204	49	SYK,PRKCD
2.751e-03	-5.90	cellular response to interleukin-6	biological process	GO:0071354	29	2	18204	49	IL6R,SBNO2
2.754e-03	-5.89	Arginosuc_syn_C	pfam domains	PF20979	1	1	17795	49	ASS1
2.754e-03	-5.89	MHCassoc_trimer	pfam domains	PF08831	1	1	17795	49	CD74
2.754e-03	-5.89	MHC2-interact	pfam domains	PF09307	1	1	17795	49	CD74
2.754e-03	-5.89	Arginosuc_synth	pfam domains	PF00764	1	1	17795	49	ASS1
2.758e-03	-5.89	CSF2RB (colony stimulating factor 2 receptor subunit beta)	protein interactions	1439	31	2	19454	49	SYK,PTPN6
2.829e-03	-5.87	JAK1 (Janus kinase 1)	protein interactions	3716	234	4	19454	49	PTPN6,PLCG2,GAB1,SYK
2.836e-03	-5.87	negative regulation of immune system process	biological process	GO:0002683	529	6	18204	49	CD74,SYK,VSIR,RIN3,PTPN6,RHBDF2
2.847e-03	-5.86	response to organonitrogen compound	biological process	GO:0010243	915	8	18204	49	IRF5,P2RY2,PTAFR,ASS1,PRKCD,SYK,P2RY6,GAB1
2.889e-03	-5.85	regulation of kinase activity	biological process	GO:0043549	531	6	18204	49	IL6R,APOE,PRKCD,CD74,PIK3R5,CSF1R
2.907e-03	-5.84	Signaling events mediated by VEGFR1 and VEGFR2	Pathway Interaction DB	vegfr1_2_pathway	63	4	2226	22	PTPN6,HIF1A,NCK1,GAB1
2.918e-03	-5.84	Fc epsilon RI signaling pathway	KEGG pathways	ko04664	67	3	7161	31	VAV1,PLCG2,SYK
2.918e-03	-5.84	Fc epsilon RI signaling pathway	KEGG pathways	hsa04664	67	3	7161	31	PLCG2,SYK,VAV1
2.921e-03	-5.84	cellular response to molecule of bacterial origin	biological process	GO:0071219	221	4	18204	49	SBNO2,ASS1,PLCG2,PTAFR
2.921e-03	-5.84	leukocyte mediated immunity	biological process	GO:0002443	221	4	18204	49	CD74,PRKCD,SYK,PTPN6
2.937e-03	-5.83	CC2D1B (coiled-coil and C2 domain containing 1B)	protein interactions	200014	32	2	19454	49	TLN1,SKAP1
2.942e-03	-5.83	regulation of superoxide metabolic process	biological process	GO:0090322	30	2	18204	49	PRKCD,SYK
2.971e-03	-5.82	cellular response to lipid	biological process	GO:0071396	534	6	18204	49	SBNO2,P2RY6,PLCG2,SYK,ASS1,PTAFR
2.971e-03	-5.82	regulation of response to biotic stimulus	biological process	GO:0002831	534	6	18204	49	SYK,APOE,VAV1,PTPN6,GSDME,PLCG2
2.975e-03	-5.82	positive regulation of macromolecule metabolic process	biological process	GO:0010604	3485	18	18204	49	CD74,PLCG2,VSIR,NCK1,IL6R,PRKCD,CSF1R,HIF1A,PTAFR,BLNK,ARAP1,SBNO2,SKAP1,SYK,APOE,PIK3R5,DENND1B,IRF5
3.080e-03	-5.78	CH	prosite domains	PS50021	81	3	12186	44	VAV1,PARVG,EHBP1L1
3.081e-03	-5.78	PRKCA (protein kinase C alpha)	protein interactions	5578	395	5	19454	49	AKAP13,PTPN6,PLCG2,SYK,PRKCD
3.095e-03	-5.78	testis	COSMIC cancer mutations	testis	733	7	16828	45	RIN3,NEK6,SYK,RHBDF2,ADCY7,CSF1R,PRKCD
3.098e-03	-5.78	SLC1A5 (solute carrier family 1 member 5)	protein interactions	6510	240	4	19454	49	RIN3,RHBDF2,NEK6,P2RY6
3.115e-03	-5.77	MAPK3 (mitogen-activated protein kinase 3)	protein interactions	5595	396	5	19454	49	HIF1A,GAB1,PRKCD,SYK,RIN3
3.149e-03	-5.76	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	3	18204	49	SYK,PLCG2,PTAFR
3.212e-03	-5.74	cell junction	cellular component	GO:0030054	2224	13	19108	49	CDH18,APOE,PTPN6,VAV1,GIT2,SKAP1,PARVG,FYB1,NCK1,GAB1,PRKCD,ARHGAP33,TLN1
3.232e-03	-5.73	phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	GO:0007200	110	3	18204	49	P2RY6,P2RY2,PTAFR
3.243e-03	-5.73	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	16	16828	45	PTPN6,ELMO1,PIK3R5,VAV1,P2RY2,SYK,RIN3,PLCG2,GAB1,PDE11A,CSF1R,NCK1,PRKCD,TLN1,P2RY6,HIF1A
3.243e-03	-5.73	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	16	16828	45	PLCG2,RIN3,VAV1,P2RY2,SYK,GAB1,CSF1R,PDE11A,NCK1,TLN1,PRKCD,P2RY6,HIF1A,ELMO1,PIK3R5,PTPN6
3.248e-03	-5.73	MHC class II-associated invariant chain, trimerisation domain	gene3d domains	1.10.870.10	1	1	14470	47	CD74
3.248e-03	-5.73	Single helix bin	gene3d domains	1.20.5.470	1	1	14470	47	ASS1
3.248e-03	-5.73	Argininosuccinate synthetase, chain A, domain 2	gene3d domains	3.90.1260.10	1	1	14470	47	ASS1
3.271e-03	-5.72	pleura-mesothelioma	COSMIC cancer mutations	pleura-mesothelioma	4189	20	16828	45	ARHGAP33,PIK3R5,PTPN6,ARHGAP15,NEK6,IL6R,PREX1,IRF5,NCK1,CSF1R,GAB1,HIF1A,PRKCD,TLN1,AKAP13,GIT2,PLCG2,VAV1,SEMA4A,SYK
3.295e-03	-5.72	P2YPURNOCPTR	prints domains	PR01157	24	2	5227	19	P2RY2,P2RY6
3.312e-03	-5.71	ITGB7 (integrin subunit beta 7)	protein interactions	3695	34	2	19454	49	PRKCD,TLN1
3.344e-03	-5.70	lipopolysaccharide-mediated signaling pathway	biological process	GO:0031663	32	2	18204	49	PLCG2,PTAFR
3.406e-03	-5.68	localization within membrane	biological process	GO:0051668	549	6	18204	49	RHBDF2,DENND1B,FYB1,DOCK2,SKAP1,APOE
3.421e-03	-5.68	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	9	16828	45	NEK6,ARHGAP15,SYK,GAB1,BLNK,CSF1R,PDE11A,PRKCD,DOCK2
3.421e-03	-5.68	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	9	16828	45	DOCK2,PRKCD,PDE11A,CSF1R,BLNK,GAB1,SYK,ARHGAP15,NEK6
3.442e-03	-5.67	Arf GTPase activating protein	gene3d domains	1.10.220.150	27	2	14470	47	ARAP1,GIT2
3.449e-03	-5.67	BCR signaling pathway	Pathway Interaction DB	bcr_5pathway	66	4	2226	22	PLCG2,SYK,BLNK,PTPN6
3.486e-03	-5.66	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	3	18204	49	SYK,PTAFR,PLCG2
3.507e-03	-5.65	IL2RB (interleukin 2 receptor subunit beta)	protein interactions	3560	35	2	19454	49	SYK,PTPN6
3.507e-03	-5.65	PAK3 (p21 (RAC1) activated kinase 3)	protein interactions	5063	35	2	19454	49	NCK1,GIT2
3.507e-03	-5.65	MT2A (metallothionein 2A)	protein interactions	4502	35	2	19454	49	ASS1,RIN3
3.534e-03	-5.65	NUP93 (nucleoporin 93)	protein interactions	9688	249	4	19454	49	HIF1A,RIN3,VAV1,NEK6
3.551e-03	-5.64	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	21	16828	45	TLN1,PRKCD,HIF1A,GAB1,CSF1R,NCK1,PLCG2,GIT2,AKAP13,SYK,SEMA4A,VAV1,PIK3R5,ARHGAP33,PTPN6,DOCK2,NEK6,ARHGAP15,IRF5,IL6R,PREX1
3.551e-03	-5.64	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	21	16828	45	AKAP13,PLCG2,GIT2,VAV1,SEMA4A,SYK,NCK1,CSF1R,GAB1,HIF1A,PRKCD,TLN1,ARHGAP15,NEK6,PREX1,IL6R,IRF5,ARHGAP33,PIK3R5,DOCK2,PTPN6
3.553e-03	-5.64	negative regulation of inflammatory response to antigenic stimulus	biological process	GO:0002862	33	2	18204	49	SYK,RHBDF2
3.583e-03	-5.63	response to virus	biological process	GO:0009615	383	5	18204	49	NCK1,HIF1A,WDFY4,GSDME,IRF5
3.611e-03	-5.62	ARGININOSUCCIN_SYN_1	prosite domains	PS00564	1	1	12186	44	ASS1
3.611e-03	-5.62	ARGININOSUCCIN_SYN_2	prosite domains	PS00565	1	1	12186	44	ASS1
3.635e-03	-5.62	CD74ANTIGEN	prints domains	PR01990	1	1	5227	19	CD74
3.635e-03	-5.62	P2Y2PRNOCPTR	prints domains	PR00594	1	1	5227	19	P2RY2
3.635e-03	-5.62	HYPOXIAIF1A	prints domains	PR01080	1	1	5227	19	HIF1A
3.635e-03	-5.62	PAFRECEPTOR	prints domains	PR01153	1	1	5227	19	PTAFR
3.635e-03	-5.62	P2Y6PRNOCPTR	prints domains	PR01068	1	1	5227	19	P2RY6
3.648e-03	-5.61	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	10	16828	45	VAV1,CD74,ARHGAP15,RIN3,ASS1,PTAFR,DOCK2,WDFY4,ELMO1,SKAP1
3.649e-03	-5.61	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	34	16828	45	CDH18,PTPN6,PARVG,PIK3R5,ARHGAP33,IRF5,MYO1F,PREX1,NEK6,ARHGAP15,TLN1,PRKCD,WDFY4,SKAP1,GAB1,ADCY7,SYK,SEMA4A,APOE,EHBP1L1,GIT2,ARAP1,DOCK2,SBNO2,IL6R,HIF1A,BLNK,NCK1,CSF1R,PDE11A,VAV1,PLCG2,RIN3,AKAP13
3.676e-03	-5.61	EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)	protein interactions	8891	123	3	19454	49	CD74,PTAFR,P2RY6
3.688e-03	-5.60	DCAF15 (DDB1 and CUL4 associated factor 15)	protein interactions	90379	252	4	19454	49	NCK1,TLN1,EHBP1L1,DOCK2
3.694e-03	-5.60	regulation of endothelial cell migration	biological process	GO:0010594	236	4	18204	49	APOE,GAB1,HIF1A,SEMA4A
3.751e-03	-5.59	regulation of lymphocyte proliferation	biological process	GO:0050670	237	4	18204	49	PTPN6,VSIR,NCK1,CD74
3.769e-03	-5.58	regulation of type 2 immune response	biological process	GO:0002828	34	2	18204	49	CD74,DENND1B
3.769e-03	-5.58	response to interleukin-6	biological process	GO:0070741	34	2	18204	49	IL6R,SBNO2
3.769e-03	-5.58	cellular response to fatty acid	biological process	GO:0071398	34	2	18204	49	PTAFR,ASS1
3.769e-03	-5.58	regulation of B cell differentiation	biological process	GO:0045577	34	2	18204	49	SYK,PTPN6
3.775e-03	-5.58	EPO signaling pathway	Pathway Interaction DB	epopathway	33	3	2226	22	PTPN6,GAB1,PLCG2
3.812e-03	-5.57	G alpha (12/13) signalling events	REACTOME pathways	R-HSA-416482	88	3	10285	37	VAV1,AKAP13,PREX1
3.887e-03	-5.55	positive regulation of response to external stimulus	biological process	GO:0032103	564	6	18204	49	PLCG2,CSF1R,VAV1,CD74,IL6R,SYK
3.894e-03	-5.55	femur	COSMIC cancer mutations	femur	1197	9	16828	45	CDH18,WDFY4,BLNK,RHBDF2,PREX1,P2RY2,AKAP13,RIN3,ARHGAP15
3.913e-03	-5.54	CARD11 (caspase recruitment domain family member 11)	protein interactions	84433	37	2	19454	49	PRKCD,FYB1
3.913e-03	-5.54	CD22 (CD22 molecule)	protein interactions	933	37	2	19454	49	PTPN6,SYK
3.933e-03	-5.54	UQCRH (ubiquinol-cytochrome c reductase hinge protein)	protein interactions	7388	126	3	19454	49	GSDME,APOE,P2RY6
3.937e-03	-5.54	regulation of receptor-mediated endocytosis	biological process	GO:0048259	118	3	18204	49	PLCG2,SYK,RIN3
4.040e-03	-5.51	regulation of mononuclear cell proliferation	biological process	GO:0032944	242	4	18204	49	CD74,VSIR,NCK1,PTPN6
4.111e-03	-5.49	MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)	protein interactions	11184	128	3	19454	49	NCK1,BLNK,SYK
4.128e-03	-5.49	regulation of apoptotic signaling pathway	biological process	GO:2001233	396	5	18204	49	CD74,PRKCD,NCK1,GSDME,HIF1A
4.152e-03	-5.48	plasma membrane protein complex	cellular component	GO:0098797	600	6	19108	49	SKAP1,CD74,SYK,CDH18,PTPN6,IL6R
4.163e-03	-5.48	REVINTRACTNG	prints domains	PR00405	27	2	5227	19	GIT2,ARAP1
4.163e-03	-5.48	regulation of leukocyte activation	biological process	GO:0002694	572	6	18204	49	NCK1,SYK,VSIR,CD74,VAV1,PTPN6
4.182e-03	-5.48	protein tyrosine kinase binding	molecular function	GO:1990782	125	3	18094	47	NCK1,PLCG2,BLNK
4.201e-03	-5.47	EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)	protein interactions	8890	129	3	19454	49	P2RY6,CD74,PTAFR
4.218e-03	-5.47	syncytium formation by plasma membrane fusion	biological process	GO:0000768	36	2	18204	49	DOCK2,SBNO2
4.218e-03	-5.47	regulation of homotypic cell-cell adhesion	biological process	GO:0034110	36	2	18204	49	PRKCD,SYK
4.218e-03	-5.47	cell-cell fusion	biological process	GO:0140253	36	2	18204	49	SBNO2,DOCK2
4.220e-03	-5.47	leukocyte migration	biological process	GO:0050900	245	4	18204	49	IL6R,SYK,VAV1,PREX1
4.223e-03	-5.47	ARFGAP	prosite domains	PS50115	27	2	12186	44	ARAP1,GIT2
4.224e-03	-5.47	positive regulation of T cell differentiation	biological process	GO:0045582	121	3	18204	49	CD74,VSIR,SYK
4.227e-03	-5.47	CDC42 (cell division cycle 42)	protein interactions	998	1280	9	19454	49	PREX1,ARHGAP27,GIT2,EHBP1L1,GMIP,ARAP1,NEK6,VAV1,PLCG2
4.229e-03	-5.47	regulation of response to stress	biological process	GO:0080134	1431	10	18204	49	PTPN6,PLCG2,RHBDF2,SBNO2,CD74,VAV1,APOE,PRKCD,NCK1,SYK
4.249e-03	-5.46	TRAF6 (TNF receptor associated factor 6)	protein interactions	7189	426	5	19454	49	PRKCD,SYK,IRF5,PTPN6,HIF1A
4.281e-03	-5.45	regulation of cell morphogenesis	biological process	GO:0022604	246	4	18204	49	ARHGAP15,ARAP1,CSF1R,SEMA4A
4.281e-03	-5.45	response to toxic substance	biological process	GO:0009636	246	4	18204	49	ASS1,ARHGAP33,IPCEF1,APOE
4.299e-03	-5.45	regulation of organelle organization	biological process	GO:0033043	1201	9	18204	49	ARAP1,CARMIL3,PREX1,NEK6,PRKCD,AKAP13,NCK1,HIF1A,CSF1R
4.377e-03	-5.43	lymph_node	COSMIC cancer mutations	lymph_node	1703	11	16828	45	CD74,CDH18,DOCK2,ELMO1,SYK,PLCG2,AKAP13,HIF1A,BLNK,PDE11A,CSF1R
4.377e-03	-5.43	ACTG1 (actin gamma 1)	protein interactions	71	429	5	19454	49	GIT2,ARHGAP27,APOE,GSDME,RIN3
4.451e-03	-5.41	negative regulation of lymphocyte apoptotic process	biological process	GO:0070229	37	2	18204	49	HIF1A,CD74
4.451e-03	-5.41	regulation of macrophage cytokine production	biological process	GO:0010935	37	2	18204	49	PLCG2,CD74
4.454e-03	-5.41	cellular response to nitrogen compound	biological process	GO:1901699	580	6	18204	49	GAB1,PRKCD,P2RY2,PTAFR,P2RY6,ASS1
4.488e-03	-5.41	CaM pathway	REACTOME pathways	R-HSA-111997	28	2	10285	37	ADCY7,PRKCD
4.488e-03	-5.41	Calmodulin induced events	REACTOME pathways	R-HSA-111933	28	2	10285	37	ADCY7,PRKCD
4.488e-03	-5.41	Dectin-2 family	REACTOME pathways	R-HSA-5621480	28	2	10285	37	SYK,PLCG2
4.488e-03	-5.41	Integrin alphaIIb beta3 signaling	REACTOME pathways	R-HSA-354192	28	2	10285	37	TLN1,SYK
4.523e-03	-5.40	positive regulation of lipid metabolic process	biological process	GO:0045834	124	3	18204	49	APOE,PRKCD,CD74
4.575e-03	-5.39	PLD2 (phospholipase D2)	protein interactions	5338	133	3	19454	49	PRKCD,SKAP1,HIF1A
4.648e-03	-5.37	skin-sole-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-sole-malignant_melanoma-acral_lentiginous	254	4	16828	45	PDE11A,AKAP13,ARHGAP27,CDH18
4.651e-03	-5.37	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	ko01521	79	3	7161	31	GAB1,PLCG2,IL6R
4.651e-03	-5.37	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	hsa01521	79	3	7161	31	GAB1,PLCG2,IL6R
4.655e-03	-5.37	positive regulation of cell population proliferation	biological process	GO:0008284	992	8	18204	49	CD74,P2RY6,PTPN6,IL6R,NCK1,CSF1R,HIF1A,PTAFR
4.672e-03	-5.37	GIT2 (GIT ArfGAP 2)	protein interactions	9815	134	3	19454	49	GIT2,NCK1,ASS1
4.682e-03	-5.36	Signaling by GPCR	REACTOME pathways	R-HSA-372790	1299	11	10285	37	AKAP13,P2RY2,PIK3R5,PRKCD,P2RY6,PDE11A,PREX1,VAV1,PTAFR,TLN1,ADCY7
4.730e-03	-5.35	regulation of type I interferon production	biological process	GO:0032479	126	3	18204	49	PLCG2,IRF5,SYK
4.773e-03	-5.34	RA_dom	interpro domains	IPR000159	39	2	18521	49	RIN3,ARAP1
4.780e-03	-5.34	regulation of protein metabolic process	biological process	GO:0051246	2218	13	18204	49	PTAFR,CSF1R,HIF1A,PRKCD,NCK1,IL6R,VSIR,PLCG2,CD74,PIK3R5,APOE,SYK,PTPN6
4.803e-03	-5.34	G alpha (q) signalling events	REACTOME pathways	R-HSA-416476	192	4	10285	37	PRKCD,P2RY2,PTAFR,P2RY6
4.810e-03	-5.34	The role of Nef in HIV-1 replication and disease pathogenesis	REACTOME pathways	R-HSA-164952	29	2	10285	37	DOCK2,ELMO1
4.869e-03	-5.32	NEFL (neurofilament light chain)	protein interactions	4747	136	3	19454	49	GMIP,NEK6,SKAP1
4.923e-03	-5.31	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	13	16828	45	CDH18,DOCK2,PTPN6,SBNO2,ELMO1,VAV1,RIN3,IPCEF1,CSF1R,ADCY7,WDFY4,BLNK,SKAP1
4.929e-03	-5.31	positive regulation of protein kinase activity	biological process	GO:0045860	256	4	18204	49	PIK3R5,PRKCD,IL6R,CSF1R
4.936e-03	-5.31	syncytium formation	biological process	GO:0006949	39	2	18204	49	DOCK2,SBNO2
4.936e-03	-5.31	positive regulation of nitric oxide biosynthetic process	biological process	GO:0045429	39	2	18204	49	APOE,ASS1
4.936e-03	-5.31	acute-phase response	biological process	GO:0006953	39	2	18204	49	IL6R,ASS1
4.942e-03	-5.31	regulation of B cell activation	biological process	GO:0050864	128	3	18204	49	PTPN6,SYK,CD74
4.995e-03	-5.30	Regulation of toll-like receptor signaling pathway	WikiPathways	WP1449	145	4	5310	26	SYK,IRF5,PIK3R5,PTPN6
5.009e-03	-5.30	p75 NTR receptor-mediated signalling	REACTOME pathways	R-HSA-193704	97	3	10285	37	AKAP13,VAV1,PREX1
5.015e-03	-5.30	Type II diabetes mellitus	WikiPathways	WP1584	22	2	5310	26	PRKCD,PIK3R5
5.031e-03	-5.29	KIR2DL5A (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A)	protein interactions	57292	2	1	19454	49	PTPN6
5.031e-03	-5.29	Per1 (period circadian clock 1)	protein interactions	18626	2	1	19454	49	HIF1A
5.031e-03	-5.29	CUZD1 (CUB and zona pellucida like domains 1)	protein interactions	50624	2	1	19454	49	PTPN6
5.031e-03	-5.29	Siglece (sialic acid binding Ig-like lectin E)	protein interactions	83382	2	1	19454	49	PTPN6
5.031e-03	-5.29	HIF1A-AS2 (HIF1A antisense RNA 2)	protein interactions	100750247	2	1	19454	49	HIF1A
5.031e-03	-5.29	Arnt (aryl hydrocarbon receptor nuclear translocator)	protein interactions	11863	2	1	19454	49	HIF1A
5.031e-03	-5.29	MPIG6B (megakaryocyte and platelet inhibitory receptor G6b)	protein interactions	80739	2	1	19454	49	PTPN6
5.077e-03	-5.28	molecular condensate scaffold activity	molecular function	GO:0140693	41	2	18094	47	NCK1,BLNK
5.122e-03	-5.27	mouth	COSMIC cancer mutations	mouth	9004	33	16828	45	GIT2,SYK,APOE,EHBP1L1,PRKCD,TLN1,GAB1,WDFY4,ADCY7,NEK6,CD74,MYO1F,IRF5,PREX1,ELMO1,RHBDF2,ARHGAP33,CDH18,PARVG,PTPN6,RIN3,PLCG2,AKAP13,VAV1,P2RY2,PDE11A,CSF1R,NCK1,GMIP,DENND1B,SBNO2,ARAP1,DOCK2
5.122e-03	-5.27	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	49	APOE
5.122e-03	-5.27	chylomicron remnant	cellular component	GO:0034360	2	1	19108	49	APOE
5.122e-03	-5.27	macrophage migration inhibitory factor receptor complex	cellular component	GO:0035692	2	1	19108	49	CD74
5.122e-03	-5.27	CSF1-CSF1R complex	cellular component	GO:1990682	2	1	19108	49	CSF1R
5.141e-03	-5.27	Ca-dependent events	REACTOME pathways	R-HSA-111996	30	2	10285	37	ADCY7,PRKCD
5.160e-03	-5.27	B cell differentiation	biological process	GO:0030183	130	3	18204	49	PLCG2,BLNK,SYK
5.160e-03	-5.27	lymphocyte proliferation	biological process	GO:0046651	130	3	18204	49	DOCK2,PRKCD,PTPN6
5.160e-03	-5.27	negative regulation of T cell activation	biological process	GO:0050868	130	3	18204	49	PTPN6,VSIR,CD74
5.171e-03	-5.26	ArfGap	smart domains	SM00105	27	2	9717	39	ARAP1,GIT2
5.173e-03	-5.26	HOMEZ (homeobox and leucine zipper encoding)	protein interactions	57594	139	3	19454	49	NCK1,NEK6,PARVG
5.187e-03	-5.26	positive regulation of nitric oxide metabolic process	biological process	GO:1904407	40	2	18204	49	ASS1,APOE
5.188e-03	-5.26	interleukin-6 receptor activity	molecular function	GO:0004915	2	1	18094	47	IL6R
5.188e-03	-5.26	G protein-coupled UDP receptor activity	molecular function	GO:0045029	2	1	18094	47	P2RY6
5.188e-03	-5.26	interleukin-6 binding	molecular function	GO:0019981	2	1	18094	47	IL6R
5.188e-03	-5.26	eukaryotic initiation factor eIF2 binding	molecular function	GO:0071074	2	1	18094	47	NCK1
5.188e-03	-5.26	macrophage migration inhibitory factor binding	molecular function	GO:0035718	2	1	18094	47	CD74
5.188e-03	-5.26	macrophage colony-stimulating factor receptor activity	molecular function	GO:0005011	2	1	18094	47	CSF1R
5.216e-03	-5.26	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	17	16828	45	SBNO2,CDH18,DOCK2,PTPN6,ARHGAP15,DENND1B,TLN1,CSF1R,PDE11A,WDFY4,SKAP1,GAB1,PLCG2,RIN3,AKAP13,P2RY2,VAV1
5.241e-03	-5.25	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	49	CSF1R,SYK,NEK6
5.254e-03	-5.25	ITGA1 (integrin subunit alpha 1)	protein interactions	3672	43	2	19454	49	TLN1,PTPN6
5.284e-03	-5.24	iRhom1_2_N	interpro domains	IPR022241	2	1	18521	49	RHBDF2
5.284e-03	-5.24	Talin_R4	interpro domains	IPR049108	2	1	18521	49	TLN1
5.284e-03	-5.24	Vinculin-bd_dom	interpro domains	IPR015009	2	1	18521	49	TLN1
5.284e-03	-5.24	HIF-1_CTAD	interpro domains	IPR014887	2	1	18521	49	HIF1A
5.284e-03	-5.24	GIT_SHD	interpro domains	IPR013724	2	1	18521	49	GIT2
5.284e-03	-5.24	SNO	interpro domains	IPR026741	2	1	18521	49	SBNO2
5.284e-03	-5.24	GIT1/2_CC	interpro domains	IPR032352	2	1	18521	49	GIT2
5.284e-03	-5.24	GIT1_C	interpro domains	IPR022018	2	1	18521	49	GIT2
5.284e-03	-5.24	SBNO_Helicase_C_dom	interpro domains	IPR026937	2	1	18521	49	SBNO2
5.284e-03	-5.24	Tyr_Pase_non-rcpt_typ-6/11	interpro domains	IPR012152	2	1	18521	49	PTPN6
5.284e-03	-5.24	Tyr_kinase_non-rcpt_SYK/ZAP70	interpro domains	IPR012234	2	1	18521	49	SYK
5.284e-03	-5.24	PLC-gamma_C-SH2	interpro domains	IPR035023	2	1	18521	49	PLCG2
5.284e-03	-5.24	GIT-like	interpro domains	IPR047161	2	1	18521	49	GIT2
5.284e-03	-5.24	SKAP_fam	interpro domains	IPR037781	2	1	18521	49	SKAP1
5.284e-03	-5.24	PIK3R5/6	interpro domains	IPR019522	2	1	18521	49	PIK3R5
5.284e-03	-5.24	Kinase_SYK/ZAP-70_inter-SH2_sf	interpro domains	IPR023420	2	1	18521	49	SYK
5.284e-03	-5.24	PLC-gamma_N-SH2	interpro domains	IPR035024	2	1	18521	49	PLCG2
5.284e-03	-5.24	GSDME	interpro domains	IPR042377	2	1	18521	49	GSDME
5.284e-03	-5.24	Talin1/2-RS	interpro domains	IPR037438	2	1	18521	49	TLN1
5.284e-03	-5.24	SNO_AAA	interpro domains	IPR039187	2	1	18521	49	SBNO2
5.284e-03	-5.24	NCK	interpro domains	IPR017304	2	1	18521	49	NCK1
5.284e-03	-5.24	SYK/ZAP-70_N_SH2	interpro domains	IPR035838	2	1	18521	49	SYK
5.284e-03	-5.24	Talin_cent_sf	interpro domains	IPR036476	2	1	18521	49	TLN1
5.284e-03	-5.24	PLC-gamma	interpro domains	IPR016279	2	1	18521	49	PLCG2
5.284e-03	-5.24	Talin_cent	interpro domains	IPR015224	2	1	18521	49	TLN1
5.284e-03	-5.24	Ie/If_SH3	interpro domains	IPR035507	2	1	18521	49	MYO1F
5.290e-03	-5.24	growth factor binding	molecular function	GO:0019838	136	3	18094	47	CSF1R,RHBDF2,IL6R
5.293e-03	-5.24	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	8	19454	49	AKAP13,P2RY6,DENND1B,GIT2,RIN3,GAB1,RHBDF2,ASS1
5.376e-03	-5.23	hepatic immune response	biological process	GO:0002384	2	1	18204	49	IL6R
5.376e-03	-5.23	regulation of interleukin-3 production	biological process	GO:0032672	2	1	18204	49	SYK
5.376e-03	-5.23	positive regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000448	2	1	18204	49	CD74
5.376e-03	-5.23	positive regulation of sphingomyelin catabolic process	biological process	GO:2000755	2	1	18204	49	PRKCD
5.376e-03	-5.23	positive regulation of lipid transporter activity	biological process	GO:0110113	2	1	18204	49	PRKCD
5.376e-03	-5.23	positive regulation of transcytosis	biological process	GO:1904300	2	1	18204	49	PTAFR
5.376e-03	-5.23	positive regulation of inhibitory synapse assembly	biological process	GO:1905704	2	1	18204	49	SEMA4A
5.376e-03	-5.23	regulation of sphingomyelin catabolic process	biological process	GO:2000754	2	1	18204	49	PRKCD
5.376e-03	-5.23	serotonin secretion by platelet	biological process	GO:0002554	2	1	18204	49	SYK
5.376e-03	-5.23	regulation of transcytosis	biological process	GO:1904298	2	1	18204	49	PTAFR
5.376e-03	-5.23	negative regulation of CD8-positive, alpha-beta T cell proliferation	biological process	GO:2000565	2	1	18204	49	VSIR
5.376e-03	-5.23	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	49	APOE
5.376e-03	-5.23	response to interleukin-11	biological process	GO:0071105	2	1	18204	49	SBNO2
5.382e-03	-5.22	NCAPD3 (non-SMC condensin II complex subunit D3)	protein interactions	23310	141	3	19454	49	SKAP1,CD74,P2RY6
5.496e-03	-5.20	SH2D1A (SH2 domain containing 1A)	protein interactions	4068	44	2	19454	49	FYB1,NCK1
5.497e-03	-5.20	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	49	P2RY6,PLCG2,PTPN6
5.500e-03	-5.20	Helicase_C_4	pfam domains	PF13871	2	1	17795	49	SBNO2
5.500e-03	-5.20	HIF-1a_CTAD	pfam domains	PF08778	2	1	17795	49	HIF1A
5.500e-03	-5.20	PKC_C2	pfam domains	PF21494	2	1	17795	49	PRKCD
5.500e-03	-5.20	VBS	pfam domains	PF08913	2	1	17795	49	TLN1
5.500e-03	-5.20	GIT_CC	pfam domains	PF16559	2	1	17795	49	GIT2
5.500e-03	-5.20	iRhom1-2_N	pfam domains	PF12595	2	1	17795	49	RHBDF2
5.500e-03	-5.20	GIT1_C	pfam domains	PF12205	2	1	17795	49	GIT2
5.500e-03	-5.20	AAA_34	pfam domains	PF13872	2	1	17795	49	SBNO2
5.500e-03	-5.20	PI3K_1B_p101	pfam domains	PF10486	2	1	17795	49	PIK3R5
5.500e-03	-5.20	Talin_R4	pfam domains	PF21692	2	1	17795	49	TLN1
5.500e-03	-5.20	Talin_middle	pfam domains	PF09141	2	1	17795	49	TLN1
5.500e-03	-5.20	GIT_SHD	pfam domains	PF08518	2	1	17795	49	GIT2
5.529e-03	-5.20	response to nitrogen compound	biological process	GO:1901698	1021	8	18204	49	PRKCD,SYK,PTAFR,P2RY2,IRF5,ASS1,GAB1,P2RY6
5.556e-03	-5.19	regulation of hemopoiesis	biological process	GO:1903706	425	5	18204	49	PTPN6,HIF1A,CD74,SYK,VSIR
5.564e-03	-5.19	response to stress	biological process	GO:0006950	3388	17	18204	49	PTAFR,HIF1A,CSF1R,VAV1,PRKCD,IPCEF1,TLN1,IL6R,NCK1,PLCG2,CD74,IRF5,ASS1,APOE,SYK,PTPN6,BLNK
5.603e-03	-5.18	FGFR4 (fibroblast growth factor receptor 4)	protein interactions	2264	455	5	19454	49	P2RY6,HIF1A,PTPN6,GAB1,NCK1
5.606e-03	-5.18	CLEC7A (Dectin-1) signaling	REACTOME pathways	R-HSA-5607764	101	3	10285	37	SYK,PRKCD,PLCG2
5.612e-03	-5.18	regulation of actin filament polymerization	biological process	GO:0030833	134	3	18204	49	PRKCD,NCK1,PREX1
5.612e-03	-5.18	mononuclear cell proliferation	biological process	GO:0032943	134	3	18204	49	DOCK2,PRKCD,PTPN6
5.646e-03	-5.18	Interferon Signaling	REACTOME pathways	R-HSA-913531	201	4	10285	37	PRKCD,IRF5,PTPN6,PTAFR
5.688e-03	-5.17	sole	COSMIC cancer mutations	sole	269	4	16828	45	AKAP13,PDE11A,ARHGAP27,CDH18
5.688e-03	-5.17	angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	angioimmunoblastic_T_cell_lymphoma	269	4	16828	45	SYK,PLCG2,BLNK,CSF1R
5.706e-03	-5.17	positive regulation of interleukin-10 production	biological process	GO:0032733	42	2	18204	49	SYK,PLCG2
5.706e-03	-5.17	COPG2 (COPI coat complex subunit gamma 2)	protein interactions	26958	144	3	19454	49	RHBDF2,CD74,P2RY6
5.706e-03	-5.17	PTPN12 (protein tyrosine phosphatase non-receptor type 12)	protein interactions	5782	144	3	19454	49	PTPN6,EHBP1L1,NCK1
5.708e-03	-5.17	ErbB signaling pathway	KEGG pathways	hsa04012	85	3	7161	31	PLCG2,NCK1,GAB1
5.708e-03	-5.17	ErbB signaling pathway	KEGG pathways	ko04012	85	3	7161	31	PLCG2,NCK1,GAB1
5.729e-03	-5.16	positive regulation of lymphocyte differentiation	biological process	GO:0045621	135	3	18204	49	SYK,VSIR,CD74
5.742e-03	-5.16	PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma)	protein interactions	23396	45	2	19454	49	VAV1,TLN1
5.742e-03	-5.16	SKAP2 (src kinase associated phosphoprotein 2)	protein interactions	8935	45	2	19454	49	FYB1,SKAP1
5.760e-03	-5.16	regulation of developmental process	biological process	GO:0050793	2540	14	18204	49	HIF1A,CSF1R,IL6R,ARHGAP15,VSIR,PREX1,GAB1,CD74,ARHGAP33,SEMA4A,SYK,APOE,PTPN6,ARAP1
5.766e-03	-5.16	PRDX2 (peroxiredoxin 2)	protein interactions	7001	286	4	19454	49	AKAP13,RIN3,ASS1,APOE
5.847e-03	-5.14	regulation of MAP kinase activity	biological process	GO:0043405	136	3	18204	49	APOE,PRKCD,PIK3R5
5.932e-03	-5.13	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	26	16828	45	IRF5,CD74,MYO1F,PREX1,NEK6,CDH18,PTPN6,RHBDF2,ARHGAP33,ELMO1,SYK,APOE,GIT2,TLN1,PRKCD,ADCY7,WDFY4,ARAP1,DOCK2,SBNO2,P2RY2,VAV1,RIN3,PLCG2,AKAP13,GMIP
5.958e-03	-5.12	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	12	16828	45	PIK3R5,CDH18,DOCK2,ASS1,NEK6,TLN1,CSF1R,PDE11A,GAB1,IPCEF1,SEMA4A,VAV1
5.962e-03	-5.12	protein tyrosine kinase activity	molecular function	GO:0004713	142	3	18094	47	SYK,CSF1R,PRKCD
5.974e-03	-5.12	T-helper cell differentiation	biological process	GO:0042093	43	2	18204	49	IL6R,SEMA4A
5.974e-03	-5.12	CD4-positive, alpha-beta T cell differentiation involved in immune response	biological process	GO:0002294	43	2	18204	49	IL6R,SEMA4A
5.974e-03	-5.12	regulation of bone resorption	biological process	GO:0045124	43	2	18204	49	CSF1R,SYK
6.041e-03	-5.11	UBASH3B (ubiquitin associated and SH3 domain containing B)	protein interactions	84959	147	3	19454	49	ARAP1,SYK,NCK1
6.089e-03	-5.10	non-membrane spanning protein tyrosine kinase activity	molecular function	GO:0004715	45	2	18094	47	SYK,PRKCD
6.121e-03	-5.10	blood vessel morphogenesis	biological process	GO:0048514	435	5	18204	49	GAB1,APOE,SYK,SEMA4A,HIF1A
6.178e-03	-5.09	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	35	16828	45	ARAP1,DOCK2,DENND1B,IL6R,HIF1A,NCK1,CSF1R,PDE11A,PLCG2,RIN3,AKAP13,P2RY2,VAV1,ARHGAP33,RHBDF2,PIK3R5,ELMO1,CDH18,PARVG,PTPN6,ARHGAP15,NEK6,IRF5,MYO1F,PREX1,P2RY6,TLN1,PRKCD,ADCY7,WDFY4,GAB1,SKAP1,GIT2,SEMA4A,SYK
6.186e-03	-5.09	VEGFA-VEGFR2 Pathway	REACTOME pathways	R-HSA-4420097	330	5	10285	37	PRKCD,NCK1,VAV1,ELMO1,TLN1
6.198e-03	-5.08	Generation of second messenger molecules	REACTOME pathways	R-HSA-202433	33	2	10285	37	NCK1,FYB1
6.247e-03	-5.08	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	35	16828	45	SEMA4A,SYK,GIT2,P2RY6,TLN1,PRKCD,ADCY7,GAB1,WDFY4,SKAP1,MYO1F,IRF5,PREX1,ARHGAP15,NEK6,CDH18,PARVG,PTPN6,RHBDF2,ARHGAP33,ELMO1,PIK3R5,P2RY2,VAV1,PLCG2,RIN3,AKAP13,HIF1A,NCK1,CSF1R,PDE11A,IL6R,DENND1B,ARAP1,DOCK2
6.247e-03	-5.08	alpha-beta T cell differentiation involved in immune response	biological process	GO:0002293	44	2	18204	49	IL6R,SEMA4A
6.247e-03	-5.08	alpha-beta T cell activation involved in immune response	biological process	GO:0002287	44	2	18204	49	IL6R,SEMA4A
6.247e-03	-5.08	positive regulation of protein dephosphorylation	biological process	GO:0035307	44	2	18204	49	PRKCD,NCK1
6.247e-03	-5.08	T cell costimulation	biological process	GO:0031295	44	2	18204	49	PTPN6,VAV1
6.250e-03	-5.08	C14orf180 (chromosome 14 open reading frame 180)	protein interactions	400258	47	2	19454	49	VSIR,CD74
6.270e-03	-5.07	IVNS1ABP (influenza virus NS1A binding protein)	protein interactions	10625	149	3	19454	49	RIN3,VAV1,NCK1
6.426e-03	-5.05	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	6	18204	49	NCK1,SYK,BLNK,GAB1,CSF1R,VAV1
6.438e-03	-5.05	cytokine binding	molecular function	GO:0019955	146	3	18094	47	CD74,CSF1R,IL6R
6.461e-03	-5.04	positive regulation of chemotaxis	biological process	GO:0050921	141	3	18204	49	CSF1R,IL6R,CD74
6.486e-03	-5.04	-	gene3d domains	6.10.250.220	2	1	14470	47	SKAP1
6.527e-03	-5.03	polyol biosynthetic process	biological process	GO:0046173	45	2	18204	49	PTAFR,PLCG2
6.527e-03	-5.03	negative regulation of blood coagulation	biological process	GO:0030195	45	2	18204	49	PRKCD,APOE
6.527e-03	-5.03	response to dexamethasone	biological process	GO:0071548	45	2	18204	49	PTAFR,ASS1
6.527e-03	-5.03	lymphocyte costimulation	biological process	GO:0031294	45	2	18204	49	PTPN6,VAV1
6.527e-03	-5.03	negative regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050732	45	2	18204	49	PRKCD,PTPN6
6.527e-03	-5.03	regulation of leukocyte degranulation	biological process	GO:0043300	45	2	18204	49	PTAFR,SYK
6.527e-03	-5.03	negative regulation of insulin receptor signaling pathway	biological process	GO:0046627	45	2	18204	49	PRKCD,NCK1
6.571e-03	-5.03	DAG and IP3 signaling	REACTOME pathways	R-HSA-1489509	34	2	10285	37	ADCY7,PRKCD
6.634e-03	-5.02	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	10	16828	45	WDFY4,SKAP1,ELMO1,DOCK2,PTAFR,RIN3,ASS1,ARHGAP15,VAV1,CD74
6.716e-03	-5.00	positive regulation of apoptotic signaling pathway	biological process	GO:2001235	143	3	18204	49	GSDME,PRKCD,NCK1
6.777e-03	-4.99	ALDH1A3 (aldehyde dehydrogenase 1 family member A3)	protein interactions	220	49	2	19454	49	VAV1,HIF1A
6.777e-03	-4.99	CYTH1 (cytohesin 1)	protein interactions	9267	49	2	19454	49	IPCEF1,PRKCD
6.777e-03	-4.99	PGAP4 (post-GPI attachment to proteins GalNAc transferase 4)	protein interactions	84302	49	2	19454	49	PTAFR,P2RY2
6.812e-03	-4.99	negative regulation of cellular response to insulin stimulus	biological process	GO:1900077	46	2	18204	49	PRKCD,NCK1
6.812e-03	-4.99	negative regulation of hemostasis	biological process	GO:1900047	46	2	18204	49	PRKCD,APOE
6.814e-03	-4.99	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	36	16828	45	DOCK2,ARAP1,SBNO2,DENND1B,GMIP,BLNK,CSF1R,PDE11A,VAV1,P2RY2,AKAP13,PLCG2,RIN3,PARVG,PTPN6,CDH18,ELMO1,PIK3R5,RHBDF2,ARHGAP33,PREX1,ARHGAP27,IRF5,MYO1F,ARHGAP15,IPCEF1,GAB1,SKAP1,ADCY7,TLN1,PRKCD,P2RY6,APOE,SYK,PTAFR,GIT2
6.814e-03	-4.99	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	36	16828	45	PREX1,IRF5,ARHGAP27,MYO1F,ARHGAP15,PTPN6,PARVG,CDH18,ELMO1,PIK3R5,ARHGAP33,RHBDF2,APOE,SYK,GIT2,PTAFR,IPCEF1,GAB1,SKAP1,ADCY7,PRKCD,TLN1,P2RY6,DENND1B,DOCK2,ARAP1,SBNO2,VAV1,P2RY2,AKAP13,PLCG2,RIN3,GMIP,BLNK,CSF1R,PDE11A
6.834e-03	-4.99	Signaling by VEGF	REACTOME pathways	R-HSA-194138	338	5	10285	37	PRKCD,VAV1,NCK1,TLN1,ELMO1
6.978e-03	-4.97	regulation of innate immune response	biological process	GO:0045088	449	5	18204	49	APOE,SYK,PTPN6,PLCG2,VAV1
6.998e-03	-4.96	regulation of cell population proliferation	biological process	GO:0042127	1790	11	18204	49	CD74,PTPN6,GSDME,P2RY6,APOE,IL6R,NCK1,VSIR,PTAFR,CSF1R,HIF1A
7.006e-03	-4.96	Class I PI3K signaling events	Pathway Interaction DB	pi3kcipathway	41	3	2226	22	PREX1,PLCG2,VAV1
7.049e-03	-4.95	GHR (growth hormone receptor)	protein interactions	2690	50	2	19454	49	PTPN6,NCK1
7.096e-03	-4.95	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	6	19454	49	EHBP1L1,FYB1,PRKCD,GAB1,RHBDF2,PREX1
7.103e-03	-4.95	negative regulation of MAP kinase activity	biological process	GO:0043407	47	2	18204	49	APOE,PRKCD
7.130e-03	-4.94	SH3KBP1 (SH3 domain containing kinase binding protein 1)	protein interactions	30011	304	4	19454	49	RIN3,ARHGAP27,BLNK,ARAP1
7.241e-03	-4.93	PPP6R1 (protein phosphatase 6 regulatory subunit 1)	protein interactions	22870	157	3	19454	49	IRF5,P2RY6,CD74
7.325e-03	-4.92	SH2D2A (SH2 domain containing 2A)	protein interactions	9047	51	2	19454	49	SYK,GAB1
7.325e-03	-4.92	IL4R (interleukin 4 receptor)	protein interactions	3566	51	2	19454	49	PTPN6,RHBDF2
7.325e-03	-4.92	CD247 (CD247 molecule)	protein interactions	919	51	2	19454	49	PTPN6,DOCK2
7.346e-03	-4.91	regulation of canonical NF-kappaB signal transduction	biological process	GO:0043122	287	4	18204	49	NEK6,PLCG2,AKAP13,CD74
7.346e-03	-4.91	PLC-gamma1 signalling	REACTOME pathways	R-HSA-167021	36	2	10285	37	ADCY7,PRKCD
7.346e-03	-4.91	EGFR interacts with phospholipase C-gamma	REACTOME pathways	R-HSA-212718	36	2	10285	37	ADCY7,PRKCD
7.352e-03	-4.91	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	20	16828	45	SYK,SEMA4A,VAV1,PLCG2,GIT2,AKAP13,PRKCD,TLN1,HIF1A,GAB1,CSF1R,NCK1,IRF5,IL6R,PREX1,NEK6,ARHGAP15,PTPN6,PIK3R5,ARHGAP33
7.368e-03	-4.91	TYK2 (tyrosine kinase 2)	protein interactions	7297	158	3	19454	49	PTPN6,PTAFR,VAV1
7.387e-03	-4.91	EGF/EGFR Signaling Pathway	WikiPathways	WP437	162	4	5310	26	NCK1,VAV1,GAB1,PRKCD
7.388e-03	-4.91	Signaling Pathways in Glioblastoma	WikiPathways	WP2261	83	3	5310	26	PLCG2,GAB1,PRKCD
7.399e-03	-4.91	T cell differentiation involved in immune response	biological process	GO:0002292	48	2	18204	49	IL6R,SEMA4A
7.399e-03	-4.91	icosanoid biosynthetic process	biological process	GO:0046456	48	2	18204	49	SYK,CD74
7.399e-03	-4.91	regulation of inflammatory response to antigenic stimulus	biological process	GO:0002861	48	2	18204	49	RHBDF2,SYK
7.404e-03	-4.91	regulation of transferase activity	biological process	GO:0051338	645	6	18204	49	CSF1R,PRKCD,APOE,CD74,PIK3R5,IL6R
7.475e-03	-4.90	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	28	16828	45	ASS1,ARHGAP15,ARHGAP27,MYO1F,PREX1,PIK3R5,ELMO1,PARVG,GIT2,APOE,PRKCD,TLN1,SKAP1,WDFY4,GAB1,ADCY7,IPCEF1,DENND1B,SBNO2,DOCK2,RIN3,AKAP13,VAV1,HIF1A,BLNK,PDE11A,CSF1R,GMIP
7.479e-03	-4.90	human chr5p14.3	chromosome location	human chr5p14.3	4	1	26134	49	CDH18
7.538e-03	-4.89	LGI2 (leucine rich repeat LGI family member 2)	protein interactions	55203	3	1	19454	49	ASS1
7.538e-03	-4.89	SIGLEC11 (sialic acid binding Ig like lectin 11)	protein interactions	114132	3	1	19454	49	PTPN6
7.538e-03	-4.89	MPEG1 (macrophage expressed 1)	protein interactions	219972	3	1	19454	49	RIN3
7.538e-03	-4.89	Cops5 (COP9 signalosome subunit 5)	protein interactions	26754	3	1	19454	49	HIF1A
7.538e-03	-4.89	ORF34 (ORF34;ORF36)	protein interactions	4961504	3	1	19454	49	HIF1A
7.538e-03	-4.89	FAM220A (family with sequence similarity 220 member A)	protein interactions	84792	3	1	19454	49	NEK6
7.538e-03	-4.89	Ahr (aryl-hydrocarbon receptor)	protein interactions	11622	3	1	19454	49	HIF1A
7.538e-03	-4.89	EPYC (epiphycan)	protein interactions	1833	3	1	19454	49	PLCG2
7.538e-03	-4.89	CX3CR1 (C-X3-C motif chemokine receptor 1)	protein interactions	1524	3	1	19454	49	HIF1A
7.538e-03	-4.89	RAB6D (RAB6D, member RAS oncogene family)	protein interactions	150786	3	1	19454	49	RIN3
7.538e-03	-4.89	Cbl (Casitas B-lineage lymphoma)	protein interactions	12402	3	1	19454	49	SYK
7.538e-03	-4.89	Mta3 (metastasis associated 3)	protein interactions	116871	3	1	19454	49	NCK1
7.538e-03	-4.89	SSX4B (SSX family member 4B)	protein interactions	548313	3	1	19454	49	HIF1A
7.547e-03	-4.89	NF-kappa B signaling pathway	KEGG pathways	hsa04064	94	3	7161	31	BLNK,PLCG2,SYK
7.547e-03	-4.89	NF-kappa B signaling pathway	KEGG pathways	ko04064	94	3	7161	31	BLNK,PLCG2,SYK
7.548e-03	-4.89	TUBA1A (tubulin alpha 1a)	protein interactions	7846	692	6	19454	49	HIF1A,TLN1,CD74,VAV1,SYK,NCK1
7.640e-03	-4.87	small molecule biosynthetic process	biological process	GO:0044283	459	5	18204	49	SYK,CD74,ASS1,PTAFR,PLCG2
7.674e-03	-4.87	interleukin-6 receptor complex	cellular component	GO:0005896	3	1	19108	49	IL6R
7.674e-03	-4.87	ciliary neurotrophic factor receptor complex	cellular component	GO:0070110	3	1	19108	49	IL6R
7.677e-03	-4.87	HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha)	protein interactions	3030	491	5	19454	49	P2RY6,CD74,SYK,APOE,RIN3
7.699e-03	-4.87	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	7	16828	45	SYK,RIN3,NEK6,ADCY7,CSF1R,RHBDF2,PRKCD
7.700e-03	-4.87	negative regulation of coagulation	biological process	GO:0050819	49	2	18204	49	PRKCD,APOE
7.700e-03	-4.87	regulation of filopodium assembly	biological process	GO:0051489	49	2	18204	49	PRKCD,ARAP1
7.700e-03	-4.87	platelet aggregation	biological process	GO:0070527	49	2	18204	49	PTPN6,TLN1
7.765e-03	-4.86	signaling receptor complex adaptor activity	molecular function	GO:0030159	51	2	18094	47	BLNK,NCK1
7.773e-03	-4.86	A1 adenosine receptor binding	molecular function	GO:0031686	3	1	18094	47	P2RY2
7.773e-03	-4.86	platelet activating factor receptor activity	molecular function	GO:0004992	3	1	18094	47	PTAFR
7.773e-03	-4.86	interleukin-11 receptor activity	molecular function	GO:0004921	3	1	18094	47	IL6R
7.773e-03	-4.86	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	molecular function	GO:0004699	3	1	18094	47	PRKCD
7.773e-03	-4.86	G protein-coupled ADP receptor activity	molecular function	GO:0001621	3	1	18094	47	P2RY6
7.773e-03	-4.86	interleukin-11 binding	molecular function	GO:0019970	3	1	18094	47	IL6R
7.773e-03	-4.86	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	molecular function	GO:0004118	3	1	18094	47	PDE11A
7.798e-03	-4.85	negative regulation of protein phosphorylation	biological process	GO:0001933	292	4	18204	49	NCK1,APOE,PRKCD,PTPN6
7.806e-03	-4.85	MAPK1 (mitogen-activated protein kinase 1)	protein interactions	5594	493	5	19454	49	HIF1A,VAV1,RIN3,GAB1,PRKCD
7.832e-03	-4.85	RA	prosite domains	PS50200	37	2	12186	44	RIN3,ARAP1
7.871e-03	-4.84	VDAC1 (voltage dependent anion channel 1)	protein interactions	7416	494	5	19454	49	P2RY6,RIN3,VAV1,CD74,APOE
7.891e-03	-4.84	DOK3 (docking protein 3)	protein interactions	79930	53	2	19454	49	RIN3,BLNK
7.891e-03	-4.84	ELMO2 (engulfment and cell motility 2)	protein interactions	63916	53	2	19454	49	ELMO1,DOCK2
7.891e-03	-4.84	GNA12 (G protein subunit alpha 12)	protein interactions	2768	53	2	19454	49	AKAP13,PRKCD
7.891e-03	-4.84	VAV3 (vav guanine nucleotide exchange factor 3)	protein interactions	10451	53	2	19454	49	GAB1,BLNK
7.916e-03	-4.84	hSH3	interpro domains	IPR029294	3	1	18521	49	FYB1
7.916e-03	-4.84	CARMIL_PH	interpro domains	IPR041245	3	1	18521	49	CARMIL3
7.916e-03	-4.84	ELMO_ARM	interpro domains	IPR024574	3	1	18521	49	ELMO1
7.916e-03	-4.84	RhoGAP_ARAP	interpro domains	IPR037858	3	1	18521	49	ARAP1
7.916e-03	-4.84	RII-bd_1	interpro domains	IPR018459	3	1	18521	49	AKAP13
7.916e-03	-4.84	FERM_f0	interpro domains	IPR032425	3	1	18521	49	TLN1
7.916e-03	-4.84	DENND1A/B/C	interpro domains	IPR040032	3	1	18521	49	DENND1B
7.916e-03	-4.84	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	49	HIF1A
7.916e-03	-4.84	PH_Vav	interpro domains	IPR037832	3	1	18521	49	VAV1
7.916e-03	-4.84	Parvin	interpro domains	IPR028433	3	1	18521	49	PARVG
7.916e-03	-4.84	CARMIL_C	interpro domains	IPR031943	3	1	18521	49	CARMIL3
7.916e-03	-4.84	FYB1/2-like	interpro domains	IPR043443	3	1	18521	49	FYB1
7.941e-03	-4.84	regulation of actin polymerization or depolymerization	biological process	GO:0008064	152	3	18204	49	PRKCD,NCK1,PREX1
7.941e-03	-4.84	regulation of lipid transport	biological process	GO:0032368	152	3	18204	49	SYK,PRKCD,APOE
7.974e-03	-4.83	ATP5PO (ATP synthase peripheral stalk subunit OSCP)	protein interactions	539	314	4	19454	49	VAV1,PREX1,APOE,P2RY6
8.007e-03	-4.83	modulation by host of viral process	biological process	GO:0044788	50	2	18204	49	CSF1R,APOE
8.007e-03	-4.83	cellular response to cAMP	biological process	GO:0071320	50	2	18204	49	ASS1,PTAFR
8.008e-03	-4.83	IL6-mediated signaling events	Pathway Interaction DB	il6_7pathway	43	3	2226	22	IL6R,PRKCD,VAV1
8.011e-03	-4.83	GIT	smart domains	SM00555	2	1	9717	39	GIT2
8.024e-03	-4.83	SOCS1 (suppressor of cytokine signaling 1)	protein interactions	8651	163	3	19454	49	CSF1R,VAV1,NCK1
8.040e-03	-4.82	regulation of programmed cell death	biological process	GO:0043067	1569	10	18204	49	CSF1R,HIF1A,IRF5,SYK,NCK1,PRKCD,PLCG2,GSDME,PTPN6,CD74
8.054e-03	-4.82	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	49	APOE
8.054e-03	-4.82	myeloid dendritic cell activation involved in immune response	biological process	GO:0002277	3	1	18204	49	DOCK2
8.054e-03	-4.82	follicular B cell differentiation	biological process	GO:0002316	3	1	18204	49	PLCG2
8.054e-03	-4.82	positive regulation of phospholipid catabolic process	biological process	GO:0060697	3	1	18204	49	PRKCD
8.054e-03	-4.82	cellular response to oleic acid	biological process	GO:0071400	3	1	18204	49	ASS1
8.054e-03	-4.82	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	49	APOE
8.054e-03	-4.82	serotonin secretion involved in inflammatory response	biological process	GO:0002442	3	1	18204	49	SYK
8.054e-03	-4.82	cellular response to amine stimulus	biological process	GO:0071418	3	1	18204	49	ASS1
8.054e-03	-4.82	neural fold elevation formation	biological process	GO:0021502	3	1	18204	49	HIF1A
8.054e-03	-4.82	response to mycotoxin	biological process	GO:0010046	3	1	18204	49	ASS1
8.054e-03	-4.82	serotonin production involved in inflammatory response	biological process	GO:0002351	3	1	18204	49	SYK
8.054e-03	-4.82	positive regulation of chemokine-mediated signaling pathway	biological process	GO:0070101	3	1	18204	49	HIF1A
8.054e-03	-4.82	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	biological process	GO:0086023	3	1	18204	49	AKAP13
8.054e-03	-4.82	positive regulation of cap-independent translational initiation	biological process	GO:1903679	3	1	18204	49	NCK1
8.054e-03	-4.82	regulation of cap-independent translational initiation	biological process	GO:1903677	3	1	18204	49	NCK1
8.054e-03	-4.82	membrane raft polarization	biological process	GO:0001766	3	1	18204	49	DOCK2
8.054e-03	-4.82	regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000446	3	1	18204	49	CD74
8.054e-03	-4.82	serotonin secretion	biological process	GO:0001820	3	1	18204	49	SYK
8.054e-03	-4.82	positive regulation of excitatory synapse assembly	biological process	GO:1904891	3	1	18204	49	SEMA4A
8.054e-03	-4.82	termination of signal transduction	biological process	GO:0023021	3	1	18204	49	PRKCD
8.054e-03	-4.82	beta selection	biological process	GO:0043366	3	1	18204	49	SYK
8.160e-03	-4.81	Platelet Aggregation (Plug Formation)	REACTOME pathways	R-HSA-76009	38	2	10285	37	TLN1,SYK
8.238e-03	-4.80	ELMO_ARM	pfam domains	PF11841	3	1	17795	49	ELMO1
8.238e-03	-4.80	CARMIL_C	pfam domains	PF16000	3	1	17795	49	CARMIL3
8.238e-03	-4.80	RII_binding_1	pfam domains	PF10522	3	1	17795	49	AKAP13
8.238e-03	-4.80	Carm_PH	pfam domains	PF17888	3	1	17795	49	CARMIL3
8.238e-03	-4.80	hSH3	pfam domains	PF14603	3	1	17795	49	FYB1
8.238e-03	-4.80	FERM_f0	pfam domains	PF16511	3	1	17795	49	TLN1
8.238e-03	-4.80	HIF-1	pfam domains	PF11413	3	1	17795	49	HIF1A
8.310e-03	-4.79	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	11	19454	49	RIN3,ARAP1,IL6R,RHBDF2,ASS1,BLNK,SBNO2,NEK6,AKAP13,DENND1B,HIF1A
8.320e-03	-4.79	regulation of granulocyte chemotaxis	biological process	GO:0071622	51	2	18204	49	CD74,CSF1R
8.320e-03	-4.79	regulation of bone remodeling	biological process	GO:0046850	51	2	18204	49	CSF1R,SYK
8.328e-03	-4.79	upper_leg	COSMIC cancer mutations	upper_leg	880	7	16828	45	ELMO1,CSF1R,DOCK2,NEK6,ASS1,ARHGAP15,SEMA4A
8.345e-03	-4.79	regulation of protein kinase activity	biological process	GO:0045859	469	5	18204	49	CSF1R,IL6R,APOE,PRKCD,PIK3R5
8.362e-03	-4.78	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	45	16828	45	ARAP1,DOCK2,SBNO2,GMIP,RIN3,CDH18,RHBDF2,ELMO1,PIK3R5,MYO1F,CD74,ARHGAP27,IRF5,ARHGAP15,ASS1,IPCEF1,P2RY6,PRKCD,GAB1,WDFY4,SKAP1,SEMA4A,EHBP1L1,APOE,GIT2,PTAFR,IL6R,DENND1B,HIF1A,PDE11A,CSF1R,NCK1,BLNK,P2RY2,VAV1,PLCG2,AKAP13,PTPN6,PARVG,ARHGAP33,PREX1,NEK6,TLN1,ADCY7,SYK
8.377e-03	-4.78	regulation of actin filament length	biological process	GO:0030832	155	3	18204	49	PREX1,PRKCD,NCK1
8.434e-03	-4.78	TBL2 (transducin beta like 2)	protein interactions	26608	166	3	19454	49	P2RY6,PTAFR,SKAP1
8.477e-03	-4.77	DOCK1 (dedicator of cytokinesis 1)	protein interactions	1793	55	2	19454	49	ELMO1,IPCEF1
8.573e-03	-4.76	EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon)	protein interactions	8893	167	3	19454	49	P2RY6,CD74,PTAFR
8.607e-03	-4.76	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	6	18204	49	ARHGAP33,PREX1,NCK1,APOE,PRKCD,ARAP1
8.713e-03	-4.74	KLK10 (kallikrein related peptidase 10)	protein interactions	5655	168	3	19454	49	APOE,PTPN6,MYO1F
8.752e-03	-4.74	RHOU (ras homolog family member U)	protein interactions	58480	507	5	19454	49	GIT2,EHBP1L1,GAB1,NCK1,SYK
8.776e-03	-4.74	EML3 (EMAP like 3)	protein interactions	256364	56	2	19454	49	NEK6,SKAP1
8.804e-03	-4.73	face	COSMIC cancer mutations	face	2139	12	16828	45	SEMA4A,VAV1,TLN1,GAB1,CSF1R,PDE11A,IPCEF1,ASS1,NEK6,PIK3R5,CDH18,DOCK2
8.826e-03	-4.73	regulation of blood vessel endothelial cell migration	biological process	GO:0043535	158	3	18204	49	HIF1A,APOE,GAB1
8.962e-03	-4.71	positive regulation of calcium-mediated signaling	biological process	GO:0050850	53	2	18204	49	SYK,PLCG2
9.070e-03	-4.70	PXN (paxillin)	protein interactions	5829	326	4	19454	49	TLN1,SYK,NCK1,GIT2
9.081e-03	-4.70	PTPRC (protein tyrosine phosphatase receptor type C)	protein interactions	5788	57	2	19454	49	PTPN6,SKAP1
9.193e-03	-4.69	HIF-1 signaling pathway	KEGG pathways	hsa04066	101	3	7161	31	HIF1A,PLCG2,IL6R
9.273e-03	-4.68	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	5	10285	37	ADCY7,PRKCD,VAV1,TLN1,GAB1
9.290e-03	-4.68	negative regulation of supramolecular fiber organization	biological process	GO:1902904	161	3	18204	49	APOE,ARAP1,PRKCD
9.290e-03	-4.68	positive regulation of receptor-mediated endocytosis	biological process	GO:0048260	54	2	18204	49	PLCG2,SYK
9.290e-03	-4.68	positive regulation of dephosphorylation	biological process	GO:0035306	54	2	18204	49	PRKCD,NCK1
9.444e-03	-4.66	T cell receptor signaling pathway	KEGG pathways	hsa04660	102	3	7161	31	PTPN6,VAV1,NCK1
9.444e-03	-4.66	T cell receptor signaling pathway	KEGG pathways	ko04660	102	3	7161	31	VAV1,PTPN6,NCK1
9.544e-03	-4.65	regulation of anatomical structure morphogenesis	biological process	GO:0022603	894	7	18204	49	HIF1A,CSF1R,ARHGAP33,SEMA4A,ARHGAP15,GAB1,ARAP1
9.606e-03	-4.65	receptor-mediated endocytosis	biological process	GO:0006898	163	3	18204	49	APOE,SYK,ARHGAP27
9.625e-03	-4.64	CD4-positive, alpha-beta T cell differentiation	biological process	GO:0043367	55	2	18204	49	SEMA4A,IL6R
9.625e-03	-4.64	neural crest cell migration	biological process	GO:0001755	55	2	18204	49	SEMA4A,HIF1A
9.662e-03	-4.64	Regulation of RhoA activity	Pathway Interaction DB	rhoa_reg_pathway	46	3	2226	22	ARAP1,AKAP13,VAV1
9.679e-03	-4.64	regulation of cell projection organization	biological process	GO:0031344	683	6	18204	49	ARAP1,PREX1,NCK1,PRKCD,APOE,ARHGAP33
9.703e-03	-4.64	C1_1	pfam domains	PF00130	54	2	17795	49	VAV1,PRKCD
9.713e-03	-4.63	-	gene3d domains	6.10.140.1000	3	1	14470	47	DENND1B
9.713e-03	-4.63	-	gene3d domains	6.10.250.810	3	1	14470	47	ELMO1
9.721e-03	-4.63	pleura	COSMIC cancer mutations	pleura	4914	21	16828	45	PLCG2,GIT2,AKAP13,SYK,SEMA4A,VAV1,PRKCD,TLN1,HIF1A,GAB1,NCK1,CSF1R,NEK6,ARHGAP15,IRF5,IL6R,PREX1,PIK3R5,ARHGAP33,CDH18,PTPN6
9.767e-03	-4.63	negative regulation of lymphocyte activation	biological process	GO:0051250	164	3	18204	49	VSIR,CD74,PTPN6
9.767e-03	-4.63	positive regulation of leukocyte proliferation	biological process	GO:0070665	164	3	18204	49	CSF1R,NCK1,CD74
9.811e-03	-4.62	tube morphogenesis	biological process	GO:0035239	685	6	18204	49	SEMA4A,HIF1A,CSF1R,APOE,GAB1,SYK
9.887e-03	-4.62	DSG1 (desmoglein 1)	protein interactions	1828	176	3	19454	49	NCK1,GAB1,VAV1
9.895e-03	-4.62	negative regulation of phosphorylation	biological process	GO:0042326	313	4	18204	49	PTPN6,PRKCD,APOE,NCK1
9.964e-03	-4.61	response to fatty acid	biological process	GO:0070542	56	2	18204	49	ASS1,PTAFR
9.964e-03	-4.61	negative regulation of leukocyte apoptotic process	biological process	GO:2000107	56	2	18204	49	CD74,HIF1A
1.000e-02	-4.60	positive regulation of response to biotic stimulus	biological process	GO:0002833	314	4	18204	49	SYK,VAV1,GSDME,PLCG2
1.002e-02	-4.60	DOCK2 (dedicator of cytokinesis 2)	protein interactions	1794	60	2	19454	49	VAV1,ELMO1
1.004e-02	-4.60	H1-10-AS1 (H1-10 antisense RNA 1)	protein interactions	339942	4	1	19454	49	PTPN6
1.004e-02	-4.60	CYP46A1 (cytochrome P450 family 46 subfamily A member 1)	protein interactions	10858	4	1	19454	49	RIN3
1.004e-02	-4.60	ANKRD42 (ankyrin repeat domain 42)	protein interactions	338699	4	1	19454	49	RIN3
1.004e-02	-4.60	PLEKHD1 (pleckstrin homology and coiled-coil domain containing D1)	protein interactions	400224	4	1	19454	49	SYK
1.004e-02	-4.60	Ocln (occludin)	protein interactions	18260	4	1	19454	49	PRKCD
1.004e-02	-4.60	CD34 (CD34 molecule)	protein interactions	947	4	1	19454	49	PRKCD
1.004e-02	-4.60	Mapk1 (mitogen activated protein kinase 1)	protein interactions	116590	4	1	19454	49	HIF1A
1.006e-02	-4.60	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	7	19454	49	AKAP13,RIN3,PRKCD,P2RY6,DENND1B,GAB1,CD74
1.009e-02	-4.60	lymphocyte mediated immunity	biological process	GO:0002449	166	3	18204	49	PRKCD,CD74,PTPN6
1.013e-02	-4.59	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	5	10285	37	SYK,TLN1,GAB1,PLCG2,VAV1
1.019e-02	-4.59	IPO8 (importin 8)	protein interactions	10526	178	3	19454	49	P2RY2,RIN3,P2RY6
1.022e-02	-4.58	phosphatidylinositol 3-kinase complex, class IB	cellular component	GO:0005944	4	1	19108	49	PIK3R5
1.022e-02	-4.58	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	49	APOE
1.031e-02	-4.57	mesenchymal cell migration	biological process	GO:0090497	57	2	18204	49	SEMA4A,HIF1A
1.031e-02	-4.57	regulation of lymphocyte apoptotic process	biological process	GO:0070228	57	2	18204	49	HIF1A,CD74
1.031e-02	-4.57	regulation of myeloid leukocyte mediated immunity	biological process	GO:0002886	57	2	18204	49	PTAFR,SYK
1.031e-02	-4.57	osteoclast differentiation	biological process	GO:0030316	57	2	18204	49	CSF1R,SBNO2
1.035e-02	-4.57	ciliary neurotrophic factor receptor activity	molecular function	GO:0004897	4	1	18094	47	IL6R
1.035e-02	-4.57	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	47	APOE
1.043e-02	-4.56	actin cytoskeleton	cellular component	GO:0015629	520	5	19108	49	FYB1,AKAP13,PARVG,ARHGAP33,MYO1F
1.044e-02	-4.56	C2_domain_sf	interpro domains	IPR035892	171	3	18521	49	PRKCD,DOCK2,PLCG2
1.054e-02	-4.55	ILWEQ_dom	interpro domains	IPR002558	4	1	18521	49	TLN1
1.054e-02	-4.55	Prot_kin_PKC_delta	interpro domains	IPR014376	4	1	18521	49	PRKCD
1.054e-02	-4.55	Gab1-4-like	interpro domains	IPR046355	4	1	18521	49	GAB1
1.054e-02	-4.55	I/LWEQ_dom_sf	interpro domains	IPR035964	4	1	18521	49	TLN1
1.054e-02	-4.55	NT-C2	interpro domains	IPR019448	4	1	18521	49	EHBP1L1
1.054e-02	-4.55	ApoA_E	interpro domains	IPR000074	4	1	18521	49	APOE
1.054e-02	-4.55	cytoplasm	cellular component	GO:0005737	12081	39	19108	49	IPCEF1,RHBDF2,PTAFR,ASS1,DOCK2,APOE,AKAP13,ARHGAP33,GMIP,CARMIL3,TLN1,PREX1,WDFY4,PARVG,CD74,ELMO1,PDE11A,ARHGAP27,GSDME,SKAP1,ARHGAP15,PLCG2,IRF5,VAV1,PRKCD,MYO1F,DENND1B,ARAP1,NCK1,SYK,RIN3,PIK3R5,EHBP1L1,NEK6,PTPN6,BLNK,HIF1A,FYB1,GAB1
1.066e-02	-4.54	mammary gland epithelium development	biological process	GO:0061180	58	2	18204	49	CSF1R,HIF1A
1.067e-02	-4.54	PRKD1 (protein kinase D1)	protein interactions	5587	181	3	19454	49	SYK,AKAP13,PLCG2
1.071e-02	-4.54	G Protein Signaling Pathways	WikiPathways	WP35	95	3	5310	26	ADCY7,PRKCD,AKAP13
1.072e-02	-4.54	positive regulation of peptidyl-serine dephosphorylation	biological process	GO:1902310	4	1	18204	49	NCK1
1.072e-02	-4.54	regulation of inhibitory synapse assembly	biological process	GO:1905702	4	1	18204	49	SEMA4A
1.072e-02	-4.54	negative regulation of mast cell activation involved in immune response	biological process	GO:0033007	4	1	18204	49	PTPN6
1.072e-02	-4.54	response to caloric restriction	biological process	GO:0061771	4	1	18204	49	APOE
1.072e-02	-4.54	regulation of mature B cell apoptotic process	biological process	GO:0002905	4	1	18204	49	CD74
1.072e-02	-4.54	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	49	APOE
1.072e-02	-4.54	arginine biosynthetic process	biological process	GO:0006526	4	1	18204	49	ASS1
1.072e-02	-4.54	positive regulation of endodeoxyribonuclease activity	biological process	GO:0032079	4	1	18204	49	PRKCD
1.072e-02	-4.54	response to oleic acid	biological process	GO:0034201	4	1	18204	49	ASS1
1.072e-02	-4.54	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	49	VSIR
1.072e-02	-4.54	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	biological process	GO:1903912	4	1	18204	49	NCK1
1.072e-02	-4.54	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	49	APOE
1.072e-02	-4.54	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031587	4	1	18204	49	P2RY6
1.072e-02	-4.54	positive regulation of neutrophil degranulation	biological process	GO:0043315	4	1	18204	49	PTAFR
1.072e-02	-4.54	macrophage colony-stimulating factor signaling pathway	biological process	GO:0038145	4	1	18204	49	CSF1R
1.072e-02	-4.54	epithelial cell differentiation involved in mammary gland alveolus development	biological process	GO:0061030	4	1	18204	49	HIF1A
1.072e-02	-4.54	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	49	APOE
1.072e-02	-4.54	B-1 B cell homeostasis	biological process	GO:0001922	4	1	18204	49	HIF1A
1.072e-02	-4.54	cellular response to molecule of fungal origin	biological process	GO:0071226	4	1	18204	49	SYK
1.072e-02	-4.54	regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032960	4	1	18204	49	P2RY6
1.072e-02	-4.54	negative regulation of mature B cell apoptotic process	biological process	GO:0002906	4	1	18204	49	CD74
1.072e-02	-4.54	positive regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032962	4	1	18204	49	P2RY6
1.072e-02	-4.54	positive regulation of mast cell cytokine production	biological process	GO:0032765	4	1	18204	49	SYK
1.075e-02	-4.53	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME pathways	R-HSA-1234162	3	1	10285	37	HIF1A
1.076e-02	-4.53	negative regulation of MAPK cascade	biological process	GO:0043409	170	3	18204	49	APOE,PRKCD,PTPN6
1.083e-02	-4.53	PRPS1 (phosphoribosyl pyrophosphate synthetase 1)	protein interactions	5631	182	3	19454	49	P2RY6,NCK1,VAV1
1.083e-02	-4.53	Proteoglycans in cancer	KEGG pathways	hsa05205	203	4	7161	31	PTPN6,GAB1,PLCG2,HIF1A
1.083e-02	-4.53	Proteoglycans in cancer	KEGG pathways	ko05205	203	4	7161	31	GAB1,PTPN6,PLCG2,HIF1A
1.089e-02	-4.52	INSR (insulin receptor)	protein interactions	3643	344	4	19454	49	PRKCD,GAB1,VAV1,PTPN6
1.097e-02	-4.51	Apolipoprotein	pfam domains	PF01442	4	1	17795	49	APOE
1.097e-02	-4.51	NT-C2	pfam domains	PF10358	4	1	17795	49	EHBP1L1
1.097e-02	-4.51	I_LWEQ	pfam domains	PF01608	4	1	17795	49	TLN1
1.101e-02	-4.51	CD3E (CD3 epsilon subunit of T-cell receptor complex)	protein interactions	916	63	2	19454	49	SYK,NCK1
1.104e-02	-4.51	specific granule lumen	cellular component	GO:0035580	62	2	19108	49	DOCK2,PTPN6
1.108e-02	-4.50	protein phosphorylation	biological process	GO:0006468	503	5	18204	49	PTPN6,NEK6,CSF1R,PRKCD,SYK
1.111e-02	-4.50	negative regulation of secretion	biological process	GO:0051048	172	3	18204	49	RHBDF2,CD74,APOE
1.115e-02	-4.50	SDHB (succinate dehydrogenase complex iron sulfur subunit B)	protein interactions	6390	184	3	19454	49	PIK3R5,RIN3,P2RY6
1.122e-02	-4.49	phosphatidylinositol phosphate binding	molecular function	GO:1901981	179	3	18094	47	GSDME,DENND1B,ARAP1
1.126e-02	-4.49	response to inorganic substance	biological process	GO:0010035	505	5	18204	49	PRKCD,ADCY7,PLCG2,HIF1A,ASS1
1.134e-02	-4.48	DGKE (diacylglycerol kinase epsilon)	protein interactions	8526	64	2	19454	49	CD74,P2RY6
1.137e-02	-4.48	positive regulation of cytokine-mediated signaling pathway	biological process	GO:0001961	60	2	18204	49	HIF1A,CD74
1.144e-02	-4.47	Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME pathways	R-HSA-2730905	131	3	10285	37	GAB1,SYK,VAV1
1.148e-02	-4.47	regulation of lipid metabolic process	biological process	GO:0019216	327	4	18204	49	PLCG2,APOE,PRKCD,CD74
1.167e-02	-4.45	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	9	19454	49	VAV1,ADCY7,PRKCD,SKAP1,PLCG2,IL6R,CD74,APOE,HIF1A
1.168e-02	-4.45	ESRRA (estrogen related receptor alpha)	protein interactions	2101	65	2	19454	49	HIF1A,PRKCD
1.169e-02	-4.45	APP (amyloid beta precursor protein)	protein interactions	351	2342	12	19454	49	PRKCD,ARHGAP15,AKAP13,APOE,PARVG,ARAP1,SYK,SKAP1,P2RY2,ASS1,PIK3R5,CD74
1.172e-02	-4.45	regulation of leukocyte differentiation	biological process	GO:1902105	329	4	18204	49	SYK,VSIR,CD74,PTPN6
1.174e-02	-4.44	bone mineralization	biological process	GO:0030282	61	2	18204	49	SBNO2,HIF1A
1.189e-02	-4.43	DDX54 (DEAD-box helicase 54)	protein interactions	79039	353	4	19454	49	SYK,SEMA4A,MYO1F,PTPN6
1.189e-02	-4.43	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	5	10285	37	VAV1,PRKCD,ADCY7,GAB1,TLN1
1.189e-02	-4.43	BCAR1 (BCAR1 scaffold protein, Cas family member)	protein interactions	9564	547	5	19454	49	DOCK2,ASS1,NCK1,TLN1,FYB1
1.200e-02	-4.42	SP1 (Sp1 transcription factor)	protein interactions	6667	354	4	19454	49	SYK,PRKCD,TLN1,HIF1A
1.215e-02	-4.41	endocytic vesicle	cellular component	GO:0030139	349	4	19108	49	CD74,SYK,APOE,RIN3
1.221e-02	-4.41	response to lipopolysaccharide	biological process	GO:0032496	333	4	18204	49	ASS1,SBNO2,PLCG2,PTAFR
1.230e-02	-4.40	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	2	10285	37	PRKCD,ADCY7
1.235e-02	-4.39	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	23	16828	45	PREX1,MYO1F,NEK6,ASS1,DOCK2,PARVG,CDH18,ARHGAP33,ELMO1,VAV1,EHBP1L1,SYK,AKAP13,PLCG2,PTAFR,GMIP,CSF1R,NCK1,PDE11A,ADCY7,GAB1,P2RY6,TLN1
1.235e-02	-4.39	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	23	16828	45	PREX1,MYO1F,ASS1,NEK6,PARVG,CDH18,ELMO1,ARHGAP33,EHBP1L1,SYK,PTAFR,GAB1,ADCY7,TLN1,P2RY6,DOCK2,VAV1,AKAP13,PLCG2,GMIP,CSF1R,NCK1,PDE11A
1.237e-02	-4.39	positive regulation of epithelial cell migration	biological process	GO:0010634	179	3	18204	49	PLCG2,HIF1A,GAB1
1.237e-02	-4.39	regulation of response to wounding	biological process	GO:1903034	179	3	18204	49	PTPN6,APOE,PRKCD
1.242e-02	-4.39	Alpha 6 Beta 4 signaling pathway	WikiPathways	WP244	35	2	5310	26	GAB1,PRKCD
1.246e-02	-4.39	peptidyl-amino acid modification	biological process	GO:0018193	518	5	18204	49	SYK,PRKCD,NEK6,CSF1R,PTPN6
1.246e-02	-4.39	PGRMC1 (progesterone receptor membrane component 1)	protein interactions	10857	358	4	19454	49	P2RY6,ARHGAP15,RIN3,CD74
1.247e-02	-4.38	central_nervous_system-brainstem-glioma	COSMIC cancer mutations	central_nervous_system-brainstem-glioma	338	4	16828	45	WDFY4,PDE11A,GIT2,ARHGAP27
1.247e-02	-4.38	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	COSMIC cancer mutations	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	181	3	16828	45	CDH18,WDFY4,ELMO1
1.249e-02	-4.38	positive regulation of interleukin-8 production	biological process	GO:0032757	63	2	18204	49	CD74,SYK
1.249e-02	-4.38	regulation of nitric oxide biosynthetic process	biological process	GO:0045428	63	2	18204	49	ASS1,APOE
1.249e-02	-4.38	response to fungus	biological process	GO:0009620	63	2	18204	49	PLCG2,SYK
1.250e-02	-4.38	UBE3C (ubiquitin protein ligase E3C)	protein interactions	9690	192	3	19454	49	HIF1A,P2RY6,CD74
1.253e-02	-4.38	SNHG11 (small nucleolar RNA host gene 11)	protein interactions	128439	5	1	19454	49	HIF1A
1.253e-02	-4.38	LINC01139 (long intergenic non-protein coding RNA 1139)	protein interactions	339535	5	1	19454	49	HIF1A
1.253e-02	-4.38	VHLL (VHL like)	protein interactions	391104	5	1	19454	49	HIF1A
1.253e-02	-4.38	NBPF6 (NBPF member 6)	protein interactions	653149	5	1	19454	49	PARVG
1.253e-02	-4.38	ANGPTL2 (angiopoietin like 2)	protein interactions	23452	5	1	19454	49	RIN3
1.253e-02	-4.38	NBR2 (neighbor of BRCA1 lncRNA 2)	protein interactions	10230	5	1	19454	49	GMIP
1.253e-02	-4.38	Vhl (von Hippel-Lindau tumor suppressor)	protein interactions	24874	5	1	19454	49	HIF1A
1.258e-02	-4.38	DNAJB6 (DnaJ heat shock protein family (Hsp40) member B6)	protein interactions	10049	359	4	19454	49	ARAP1,RIN3,HIF1A,P2RY6
1.266e-02	-4.37	WNT_subtype	COSMIC cancer mutations	WNT_subtype	182	3	16828	45	CDH18,WDFY4,ELMO1
1.274e-02	-4.36	MYOG (myogenin)	protein interactions	4656	68	2	19454	49	CDH18,NEK6
1.274e-02	-4.36	response to reactive oxygen species	biological process	GO:0000302	181	3	18204	49	PRKCD,APOE,HIF1A
1.274e-02	-4.36	cell-cell junction organization	biological process	GO:0045216	181	3	18204	49	CDH18,TLN1,CSF1R
1.274e-02	-4.36	regulation of T cell proliferation	biological process	GO:0042129	181	3	18204	49	NCK1,VSIR,PTPN6
1.276e-02	-4.36	alpha-beta T cell receptor complex	cellular component	GO:0042105	5	1	19108	49	PTPN6
1.276e-02	-4.36	B cell receptor complex	cellular component	GO:0019815	5	1	19108	49	SYK
1.280e-02	-4.36	gallbladder	COSMIC cancer mutations	gallbladder	2821	14	16828	45	PTPN6,DOCK2,ARAP1,CDH18,ELMO1,SBNO2,VAV1,AKAP13,IPCEF1,NCK1,CSF1R,ADCY7,PDE11A,TLN1
1.280e-02	-4.36	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	14	16828	45	ELMO1,SBNO2,ARAP1,CDH18,PTPN6,DOCK2,AKAP13,VAV1,TLN1,NCK1,ADCY7,PDE11A,CSF1R,IPCEF1
1.280e-02	-4.36	G alpha (z) signalling events	REACTOME pathways	R-HSA-418597	48	2	10285	37	ADCY7,PRKCD
1.280e-02	-4.36	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	2	10285	37	ADCY7,PRKCD
1.280e-02	-4.36	phosphatase binding	molecular function	GO:0019902	188	3	18094	47	CSF1R,SKAP1,SYK
1.281e-02	-4.36	multivesicular body	cellular component	GO:0005771	67	2	19108	49	APOE,CD74
1.285e-02	-4.35	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	13	16828	45	VAV1,AKAP13,PDE11A,CSF1R,NCK1,SKAP1,WDFY4,GAB1,BLNK,PREX1,ARHGAP15,DOCK2,ELMO1
1.285e-02	-4.35	SORT1 (sortilin 1)	protein interactions	6272	194	3	19454	49	P2RY6,ASS1,TLN1
1.287e-02	-4.35	positive regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001244	64	2	18204	49	GSDME,NCK1
1.293e-02	-4.35	Talin, central domain	gene3d domains	1.20.1420.10	4	1	14470	47	TLN1
1.299e-02	-4.34	modification-dependent protein binding	molecular function	GO:0140030	189	3	18094	47	PTPN6,VAV1,PLCG2
1.303e-02	-4.34	CD2AP (CD2 associated protein)	protein interactions	23607	195	3	19454	49	RIN3,RHBDF2,BLNK
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	SKAP1,ARHGAP33
1.312e-02	-4.33	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	3	18204	49	HIF1A,P2RY6,PTAFR
1.312e-02	-4.33	regulation of lipid localization	biological process	GO:1905952	183	3	18204	49	SYK,PRKCD,APOE
1.316e-02	-4.33	Hematopoietin_rcpt_L_F3_CS	interpro domains	IPR003530	5	1	18521	49	IL6R
1.316e-02	-4.33	DOCK_N	interpro domains	IPR032376	5	1	18521	49	DOCK2
1.316e-02	-4.33	Gasdermin_PUB	interpro domains	IPR041263	5	1	18521	49	GSDME
1.316e-02	-4.33	DOCK_N_sub1	interpro domains	IPR042455	5	1	18521	49	DOCK2
1.325e-02	-4.32	T cell differentiation in thymus	biological process	GO:0033077	65	2	18204	49	CD74,DOCK2
1.325e-02	-4.32	regulation of nitric oxide metabolic process	biological process	GO:0080164	65	2	18204	49	ASS1,APOE
1.326e-02	-4.32	urea cycle	BIOCYC pathways	HUMAN_PWY-4984	4	1	902	3	ASS1
1.335e-02	-4.32	angiogenesis	biological process	GO:0001525	342	4	18204	49	SYK,GAB1,HIF1A,SEMA4A
1.339e-02	-4.31	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	49	APOE
1.339e-02	-4.31	regulation of glucosylceramide catabolic process	biological process	GO:2000752	5	1	18204	49	PRKCD
1.339e-02	-4.31	negative regulation of filopodium assembly	biological process	GO:0051490	5	1	18204	49	PRKCD
1.339e-02	-4.31	connective tissue replacement involved in inflammatory response wound healing	biological process	GO:0002248	5	1	18204	49	HIF1A
1.339e-02	-4.31	cellular response to ammonium ion	biological process	GO:0071242	5	1	18204	49	ASS1
1.339e-02	-4.31	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	49	APOE
1.339e-02	-4.31	positive regulation of deoxyribonuclease activity	biological process	GO:0032077	5	1	18204	49	PRKCD
1.339e-02	-4.31	regulation of mast cell activation involved in immune response	biological process	GO:0033006	5	1	18204	49	PTPN6
1.339e-02	-4.31	positive regulation of translation in response to endoplasmic reticulum stress	biological process	GO:0036493	5	1	18204	49	NCK1
1.339e-02	-4.31	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	49	APOE
1.339e-02	-4.31	epididymis development	biological process	GO:1905867	5	1	18204	49	PTPN6
1.339e-02	-4.31	hypoxia-inducible factor-1alpha signaling pathway	biological process	GO:0097411	5	1	18204	49	HIF1A
1.339e-02	-4.31	response to molecule of fungal origin	biological process	GO:0002238	5	1	18204	49	SYK
1.339e-02	-4.31	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	49	APOE
1.339e-02	-4.31	positive regulation of cytoplasmic translational initiation	biological process	GO:1904690	5	1	18204	49	NCK1
1.339e-02	-4.31	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031585	5	1	18204	49	P2RY6
1.339e-02	-4.31	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	49	APOE
1.339e-02	-4.31	positive regulation of gastro-intestinal system smooth muscle contraction	biological process	GO:1904306	5	1	18204	49	PTAFR
1.339e-02	-4.31	regulation of gastro-intestinal system smooth muscle contraction	biological process	GO:1904304	5	1	18204	49	PTAFR
1.339e-02	-4.31	ciliary neurotrophic factor-mediated signaling pathway	biological process	GO:0070120	5	1	18204	49	IL6R
1.348e-02	-4.31	response to metal ion	biological process	GO:0010038	343	4	18204	49	ADCY7,ASS1,HIF1A,PLCG2
1.351e-02	-4.30	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051897	185	3	18204	49	PTPN6,CSF1R,PIK3R5
1.351e-02	-4.30	regulation of T cell differentiation	biological process	GO:0045580	185	3	18204	49	CD74,VSIR,SYK
1.354e-02	-4.30	Signaling events mediated by Stem cell factor receptor (c-Kit)	Pathway Interaction DB	kitpathway	52	3	2226	22	VAV1,GAB1,PTPN6
1.361e-02	-4.30	parathyroid-adenoma	COSMIC cancer mutations	parathyroid-adenoma	187	3	16828	45	PDE11A,PLCG2,PRKCD
1.364e-02	-4.29	positive regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042531	66	2	18204	49	IL6R,CSF1R
1.364e-02	-4.29	homotypic cell-cell adhesion	biological process	GO:0034109	66	2	18204	49	TLN1,PTPN6
1.365e-02	-4.29	blood vessel development	biological process	GO:0001568	530	5	18204	49	SYK,GAB1,APOE,HIF1A,SEMA4A
1.369e-02	-4.29	DOCK_N	pfam domains	PF16172	5	1	17795	49	DOCK2
1.369e-02	-4.29	Gasdermin_C	pfam domains	PF17708	5	1	17795	49	GSDME
1.390e-02	-4.28	regulation of lymphocyte mediated immunity	biological process	GO:0002706	187	3	18204	49	VAV1,PTPN6,DENND1B
1.394e-02	-4.27	FANCI (FA complementation group I)	protein interactions	55215	200	3	19454	49	NEK6,P2RY6,HIF1A
1.404e-02	-4.27	innate immune response activating cell surface receptor signaling pathway	biological process	GO:0002220	67	2	18204	49	PLCG2,SYK
1.404e-02	-4.27	positive regulation of response to cytokine stimulus	biological process	GO:0060760	67	2	18204	49	CD74,HIF1A
1.405e-02	-4.27	anatomical structure formation involved in morphogenesis	biological process	GO:0048646	964	7	18204	49	GAB1,DOCK2,SYK,SEMA4A,PTPN6,HIF1A,SBNO2
1.409e-02	-4.26	C2 domain	gene3d domains	2.60.40.150	156	3	14470	47	DOCK2,PRKCD,PLCG2
1.420e-02	-4.25	RPL22L1 (ribosomal protein L22 like 1)	protein interactions	200916	72	2	19454	49	VAV1,PTPN6
1.426e-02	-4.25	scaffold protein binding	molecular function	GO:0097110	70	2	18094	47	SYK,PLCG2
1.430e-02	-4.25	regulation of lipid biosynthetic process	biological process	GO:0046890	189	3	18204	49	CD74,APOE,PRKCD
1.432e-02	-4.25	SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta)	protein interactions	54557	202	3	19454	49	ASS1,TLN1,IL6R
1.433e-02	-4.25	Neurotrophin signaling pathway	KEGG pathways	hsa04722	119	3	7161	31	PLCG2,PRKCD,GAB1
1.433e-02	-4.25	Neurotrophin signaling pathway	KEGG pathways	ko04722	119	3	7161	31	PRKCD,PLCG2,GAB1
1.437e-02	-4.24	C2_NT	prosite domains	PS51840	4	1	12186	44	EHBP1L1
1.437e-02	-4.24	I_LWEQ	prosite domains	PS50945	4	1	12186	44	TLN1
1.437e-02	-4.24	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	2	10285	37	GAB1,PRKCD
1.444e-02	-4.24	CD4-positive, alpha-beta T cell activation	biological process	GO:0035710	68	2	18204	49	SEMA4A,IL6R
1.458e-02	-4.23	PANK4 (pantothenate kinase 4 (inactive))	protein interactions	55229	73	2	19454	49	GMIP,PTPN6
1.458e-02	-4.23	TLR9 (toll like receptor 9)	protein interactions	54106	73	2	19454	49	PRKCD,SYK
1.460e-02	-4.23	FCERI mediated MAPK activation	REACTOME pathways	R-HSA-2871796	265	4	10285	37	VAV1,PLCG2,TLN1,SYK
1.467e-02	-4.22	cell adhesion molecule binding	molecular function	GO:0050839	560	5	18094	47	TLN1,CDH18,PTPN6,SYK,NCK1
1.471e-02	-4.22	negative regulation of leukocyte activation	biological process	GO:0002695	191	3	18204	49	PTPN6,CD74,VSIR
1.475e-02	-4.22	C-type lectin receptors (CLRs)	REACTOME pathways	R-HSA-5621481	144	3	10285	37	SYK,PLCG2,PRKCD
1.477e-02	-4.22	Immunoglobulin	interpro domains	IPR013151	70	2	18521	49	CSF1R,IL6R
1.485e-02	-4.21	regulation of blood coagulation	biological process	GO:0030193	69	2	18204	49	APOE,PRKCD
1.485e-02	-4.21	acute inflammatory response	biological process	GO:0002526	69	2	18204	49	IL6R,ASS1
1.489e-02	-4.21	TNFRSF1A (TNF receptor superfamily member 1A)	protein interactions	7132	205	3	19454	49	PRKCD,SYK,PTPN6
1.489e-02	-4.21	POLRMT (RNA polymerase mitochondrial)	protein interactions	5442	205	3	19454	49	SKAP1,SYK,HIF1A
1.500e-02	-4.20	Signaling events mediated by focal adhesion kinase	Pathway Interaction DB	fak_pathway	54	3	2226	22	ELMO1,GIT2,TLN1
1.502e-02	-4.20	SETD9 (SET domain containing 9)	protein interactions	133383	6	1	19454	49	PLCG2
1.502e-02	-4.20	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	49	APOE
1.502e-02	-4.20	CD300LF (CD300 molecule like family member f)	protein interactions	146722	6	1	19454	49	PTPN6
1.502e-02	-4.20	NBPF22P (NBPF member 22, pseudogene)	protein interactions	285622	6	1	19454	49	PARVG
1.502e-02	-4.20	echA1 (enoyl-CoA hydratase EchA1)	protein interactions	886723	6	1	19454	49	PTPN6
1.502e-02	-4.20	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	49	APOE
1.509e-02	-4.19	superpathway of inositol phosphate compounds	BIOCYC pathways	HUMAN_PWY-6371	66	2	902	3	PIK3R5,PLCG2
1.512e-02	-4.19	positive regulation of leukocyte differentiation	biological process	GO:1902107	193	3	18204	49	SYK,VSIR,CD74
1.512e-02	-4.19	positive regulation of hemopoiesis	biological process	GO:1903708	193	3	18204	49	VSIR,SYK,CD74
1.529e-02	-4.18	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	49	APOE
1.534e-02	-4.18	SPTLC2 (serine palmitoyltransferase long chain base subunit 2)	protein interactions	9517	75	2	19454	49	P2RY6,RIN3
1.534e-02	-4.18	CHP1 (calcineurin like EF-hand protein 1)	protein interactions	11261	75	2	19454	49	VAV1,P2RY6
1.535e-02	-4.18	lower_third	COSMIC cancer mutations	lower_third	7961	29	16828	45	HIF1A,PDE11A,NCK1,CSF1R,RIN3,PLCG2,AKAP13,VAV1,ARAP1,DOCK2,TLN1,PRKCD,P2RY6,WDFY4,SKAP1,ADCY7,GIT2,PTAFR,SYK,PIK3R5,ELMO1,ARHGAP33,CDH18,PARVG,ASS1,ARHGAP15,ARHGAP27,MYO1F,PREX1
1.537e-02	-4.18	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	6	16828	45	NEK6,SYK,CSF1R,WDFY4,PRKCD,GMIP
1.537e-02	-4.18	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	6	16828	45	GMIP,SYK,PRKCD,NEK6,CSF1R,WDFY4
1.546e-02	-4.17	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	6	16828	45	DOCK2,PDE11A,BLNK,GAB1,ARHGAP15,RIN3
1.547e-02	-4.17	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	protein interactions	51144	208	3	19454	49	P2RY6,HIF1A,VAV1
1.547e-02	-4.17	PAK2 (p21 (RAC1) activated kinase 2)	protein interactions	5062	208	3	19454	49	DOCK2,GIT2,NCK1
1.549e-02	-4.17	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	47	APOE
1.549e-02	-4.17	LIM domain binding	molecular function	GO:0030274	6	1	18094	47	TLN1
1.549e-02	-4.17	lipopolysaccharide immune receptor activity	molecular function	GO:0001875	6	1	18094	47	PTAFR
1.549e-02	-4.17	type 1 angiotensin receptor binding	molecular function	GO:0031702	6	1	18094	47	ARAP1
1.562e-02	-4.16	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	27	16828	45	PDE11A,CSF1R,BLNK,P2RY2,VAV1,AKAP13,RIN3,DOCK2,ARAP1,SBNO2,IPCEF1,ADCY7,GAB1,WDFY4,P2RY6,TLN1,EHBP1L1,SYK,CDH18,ELMO1,PIK3R5,PREX1,CD74,IRF5,MYO1F,ARHGAP27,ASS1
1.562e-02	-4.16	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	27	16828	45	SYK,EHBP1L1,TLN1,P2RY6,GAB1,WDFY4,ADCY7,IPCEF1,ASS1,ARHGAP27,IRF5,MYO1F,CD74,PREX1,PIK3R5,ELMO1,CDH18,RIN3,AKAP13,VAV1,P2RY2,BLNK,CSF1R,PDE11A,SBNO2,ARAP1,DOCK2
1.567e-02	-4.16	regulation of hemostasis	biological process	GO:1900046	71	2	18204	49	PRKCD,APOE
1.573e-02	-4.15	RUNX2 (RUNX family transcription factor 2)	protein interactions	860	76	2	19454	49	HIF1A,PRKCD
1.577e-02	-4.15	Gasdermin_pore	interpro domains	IPR040460	6	1	18521	49	GSDME
1.577e-02	-4.15	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	49	ADCY7
1.577e-02	-4.15	ELMO_dom	interpro domains	IPR006816	6	1	18521	49	ELMO1
1.577e-02	-4.15	CAMSAP-like_CH_dom	interpro domains	IPR022613	6	1	18521	49	VAV1
1.579e-02	-4.15	vasculature development	biological process	GO:0001944	550	5	18204	49	HIF1A,SEMA4A,SYK,GAB1,APOE
1.587e-02	-4.14	clathrin-coated endocytic vesicle membrane	cellular component	GO:0030669	75	2	19108	49	APOE,CD74
1.587e-02	-4.14	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	49	TLN1,RIN3,NCK1
1.591e-02	-4.14	regulation of secretion by cell	biological process	GO:1903530	551	5	18204	49	HIF1A,RHBDF2,PTAFR,SYK,APOE
1.592e-02	-4.14	ig	pfam domains	PF00047	70	2	17795	49	CSF1R,IL6R
1.596e-02	-4.14	ILWEQ	smart domains	SM00307	4	1	9717	39	TLN1
1.597e-02	-4.14	negative regulation of immune response	biological process	GO:0050777	197	3	18204	49	SYK,RHBDF2,PTPN6
1.597e-02	-4.14	protein localization to plasma membrane	biological process	GO:0072659	197	3	18204	49	FYB1,SKAP1,RHBDF2
1.604e-02	-4.13	positive regulation of nuclease activity	biological process	GO:0032075	6	1	18204	49	PRKCD
1.604e-02	-4.13	cellular response to ether	biological process	GO:0071362	6	1	18204	49	PTAFR
1.604e-02	-4.13	positive regulation of macrophage proliferation	biological process	GO:0120041	6	1	18204	49	CSF1R
1.604e-02	-4.13	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	49	APOE
1.604e-02	-4.13	interleukin-11-mediated signaling pathway	biological process	GO:0038154	6	1	18204	49	IL6R
1.604e-02	-4.13	positive regulation of mucus secretion	biological process	GO:0070257	6	1	18204	49	P2RY2
1.604e-02	-4.13	positive regulation of cell-cell adhesion mediated by integrin	biological process	GO:0033634	6	1	18204	49	SKAP1
1.604e-02	-4.13	regulation of phospholipid translocation	biological process	GO:0061091	6	1	18204	49	PRKCD
1.604e-02	-4.13	hemoglobin biosynthetic process	biological process	GO:0042541	6	1	18204	49	HIF1A
1.604e-02	-4.13	negative regulation of cGMP-mediated signaling	biological process	GO:0010754	6	1	18204	49	PDE11A
1.604e-02	-4.13	elastin metabolic process	biological process	GO:0051541	6	1	18204	49	HIF1A
1.604e-02	-4.13	regulation of lipid transporter activity	biological process	GO:0110112	6	1	18204	49	PRKCD
1.604e-02	-4.13	regulation of mast cell cytokine production	biological process	GO:0032763	6	1	18204	49	SYK
1.604e-02	-4.13	intestinal epithelial cell maturation	biological process	GO:0060574	6	1	18204	49	HIF1A
1.604e-02	-4.13	osteoclast fusion	biological process	GO:0072675	6	1	18204	49	SBNO2
1.604e-02	-4.13	membrane raft distribution	biological process	GO:0031580	6	1	18204	49	DOCK2
1.604e-02	-4.13	negative regulation of PERK-mediated unfolded protein response	biological process	GO:1903898	6	1	18204	49	NCK1
1.604e-02	-4.13	positive regulation of translation in response to stress	biological process	GO:0032056	6	1	18204	49	NCK1
1.604e-02	-4.13	response to ammonium ion	biological process	GO:0060359	6	1	18204	49	ASS1
1.604e-02	-4.13	positive regulation of prostaglandin biosynthetic process	biological process	GO:0031394	6	1	18204	49	CD74
1.604e-02	-4.13	positive regulation of I-kappaB phosphorylation	biological process	GO:1903721	6	1	18204	49	PLCG2
1.604e-02	-4.13	response to symbiont	biological process	GO:0009608	6	1	18204	49	PTAFR
1.604e-02	-4.13	response to symbiotic bacterium	biological process	GO:0009609	6	1	18204	49	PTAFR
1.604e-02	-4.13	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	49	APOE
1.607e-02	-4.13	EPHB2 (EPH receptor B2)	protein interactions	2048	211	3	19454	49	NCK1,GAB1,CSF1R
1.607e-02	-4.13	HEATR1 (HEAT repeat containing 1)	protein interactions	55127	211	3	19454	49	HIF1A,P2RY6,P2RY2
1.613e-02	-4.13	NQO1 (NAD(P)H quinone dehydrogenase 1)	protein interactions	1728	77	2	19454	49	ASS1,HIF1A
1.613e-02	-4.13	DYM (dymeclin)	protein interactions	54808	77	2	19454	49	P2RY2,P2RY6
1.614e-02	-4.13	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	47	APOE
1.614e-02	-4.13	Dedicator of cytokinesis N-terminal subdomain	gene3d domains	1.20.1270.350	5	1	14470	47	DOCK2
1.640e-02	-4.11	ameboidal-type cell migration	biological process	GO:0001667	199	3	18204	49	SEMA4A,HIF1A,GAB1
1.640e-02	-4.11	head_neck	COSMIC cancer mutations	head_neck	15361	45	16828	45	AKAP13,PLCG2,P2RY2,VAV1,NCK1,PDE11A,CSF1R,BLNK,HIF1A,DENND1B,IL6R,SYK,ADCY7,TLN1,NEK6,PREX1,ARHGAP33,PARVG,PTPN6,RIN3,GMIP,SBNO2,DOCK2,ARAP1,GIT2,PTAFR,EHBP1L1,APOE,SEMA4A,SKAP1,WDFY4,GAB1,P2RY6,PRKCD,IPCEF1,ARHGAP15,ASS1,ARHGAP27,CD74,MYO1F,IRF5,RHBDF2,PIK3R5,ELMO1,CDH18
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY7
1.641e-02	-4.11	CAMSAP_CH	pfam domains	PF11971	6	1	17795	49	VAV1
1.641e-02	-4.11	ELMO_CED12	pfam domains	PF04727	6	1	17795	49	ELMO1
1.641e-02	-4.11	Gasdermin	pfam domains	PF04598	6	1	17795	49	GSDME
1.652e-02	-4.10	positive regulation of phagocytosis	biological process	GO:0050766	73	2	18204	49	DOCK2,PLCG2
1.652e-02	-4.10	negative regulation of wound healing	biological process	GO:0061045	73	2	18204	49	PRKCD,APOE
1.652e-02	-4.10	regulation of insulin receptor signaling pathway	biological process	GO:0046626	73	2	18204	49	PRKCD,NCK1
1.652e-02	-4.10	APBB2 (amyloid beta precursor protein binding family B member 2)	protein interactions	323	78	2	19454	49	VAV1,NCK1
1.656e-02	-4.10	urea cycle	BIOCYC pathways	META_PWY-4984	5	1	902	3	ASS1
1.656e-02	-4.10	L-citrulline-nitric oxide cycle	BIOCYC pathways	META_PWY-4983	5	1	902	3	ASS1
1.656e-02	-4.10	citrulline-nitric oxide cycle	BIOCYC pathways	HUMAN_PWY-4983	5	1	902	3	ASS1
1.658e-02	-4.10	response to oxidative stress	biological process	GO:0006979	365	4	18204	49	HIF1A,APOE,IPCEF1,PRKCD
1.659e-02	-4.10	negative regulation of multicellular organismal process	biological process	GO:0051241	1237	8	18204	49	APOE,PRKCD,CD74,VSIR,ADCY7,SEMA4A,PTPN6,HIF1A
1.668e-02	-4.09	GOLGA5 (golgin A5)	protein interactions	9950	214	3	19454	49	PTAFR,P2RY2,GIT2
1.689e-02	-4.08	XPO5 (exportin 5)	protein interactions	57510	215	3	19454	49	NEK6,P2RY6,HIF1A
1.695e-02	-4.08	regulation of coagulation	biological process	GO:0050818	74	2	18204	49	APOE,PRKCD
1.695e-02	-4.08	negative regulation of T cell proliferation	biological process	GO:0042130	74	2	18204	49	PTPN6,VSIR
1.700e-02	-4.07	RPS27A (ribosomal protein S27a)	protein interactions	6233	393	4	19454	49	GAB1,NCK1,RIN3,P2RY6
1.706e-02	-4.07	regulation of protein polymerization	biological process	GO:0032271	202	3	18204	49	PREX1,NCK1,PRKCD
1.715e-02	-4.07	soft_tissue-fibrous_tissue_and_uncertain_origin-gastrointestinal_stromal_tumour	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-gastrointestinal_stromal_tumour	75	2	16828	45	CSF1R,NCK1
1.722e-02	-4.06	negative regulation of response to stimulus	biological process	GO:0048585	1760	10	18204	49	HIF1A,APOE,PRKCD,NCK1,SYK,PTPN6,RHBDF2,PDE11A,CD74,RIN3
1.731e-02	-4.06	PLS3 (plastin 3)	protein interactions	5358	217	3	19454	49	TLN1,RIN3,PRKCD
1.732e-02	-4.06	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	13	16828	45	PTPN6,DOCK2,CDH18,ELMO1,SBNO2,IPCEF1,WDFY4,SKAP1,BLNK,ADCY7,CSF1R,VAV1,RIN3
1.733e-02	-4.06	PIR (pirin)	protein interactions	8544	80	2	19454	49	RIN3,ASS1
1.734e-02	-4.05	kidney	COSMIC cancer mutations	kidney	15380	45	16828	45	DOCK2,ARAP1,SBNO2,GMIP,RIN3,CDH18,ELMO1,PIK3R5,RHBDF2,ARHGAP27,MYO1F,IRF5,CD74,ASS1,ARHGAP15,IPCEF1,GAB1,WDFY4,SKAP1,PRKCD,P2RY6,EHBP1L1,APOE,SEMA4A,GIT2,PTAFR,IL6R,DENND1B,BLNK,NCK1,PDE11A,CSF1R,HIF1A,VAV1,P2RY2,AKAP13,PLCG2,PTPN6,PARVG,ARHGAP33,PREX1,NEK6,ADCY7,TLN1,SYK
1.738e-02	-4.05	negative regulation of protein secretion	biological process	GO:0050709	75	2	18204	49	APOE,RHBDF2
1.738e-02	-4.05	regulation of cellular response to insulin stimulus	biological process	GO:1900076	75	2	18204	49	PRKCD,NCK1
1.743e-02	-4.05	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	4	18521	49	CSF1R,NEK6,PRKCD,SYK
1.750e-02	-4.05	HGD (homogentisate 1,2-dioxygenase)	protein interactions	3081	7	1	19454	49	GIT2
1.750e-02	-4.05	NSUN7 (NOP2/Sun RNA methyltransferase family member 7)	protein interactions	79730	7	1	19454	49	PTPN6
1.750e-02	-4.05	KCNJ1 (potassium inwardly rectifying channel subfamily J member 1)	protein interactions	3758	7	1	19454	49	PRKCD
1.750e-02	-4.05	LAIR1 (leukocyte associated immunoglobulin like receptor 1)	protein interactions	3903	7	1	19454	49	PTPN6
1.750e-02	-4.05	CDHR3 (cadherin related family member 3)	protein interactions	222256	7	1	19454	49	PARVG
1.750e-02	-4.05	SIGLEC9 (sialic acid binding Ig like lectin 9)	protein interactions	27180	7	1	19454	49	PTPN6
1.750e-02	-4.05	ERCC6L2 (ERCC excision repair 6 like 2)	protein interactions	375748	7	1	19454	49	NEK6
1.750e-02	-4.05	CDH18 (cadherin 18)	protein interactions	1016	7	1	19454	49	CDH18
1.750e-02	-4.05	DNAI1 (dynein axonemal intermediate chain 1)	protein interactions	27019	7	1	19454	49	HIF1A
1.752e-02	-4.04	LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)	protein interactions	3954	218	3	19454	49	ASS1,APOE,RIN3
1.773e-02	-4.03	PAK1 (p21 (RAC1) activated kinase 1)	protein interactions	5058	219	3	19454	49	NCK1,PRKCD,GIT2
1.774e-02	-4.03	MRS2 (magnesium transporter MRS2)	protein interactions	57380	81	2	19454	49	P2RY2,GSDME
1.774e-02	-4.03	KRTAP3-3 (keratin associated protein 3-3)	protein interactions	85293	81	2	19454	49	DOCK2,P2RY6
1.774e-02	-4.03	TENT5A (terminal nucleotidyltransferase 5A)	protein interactions	55603	81	2	19454	49	RIN3,SYK
1.782e-02	-4.03	T cell proliferation	biological process	GO:0042098	76	2	18204	49	DOCK2,PTPN6
1.782e-02	-4.03	regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042509	76	2	18204	49	CSF1R,IL6R
1.783e-02	-4.03	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	9	16828	45	ARHGAP15,AKAP13,PREX1,PDE11A,SKAP1,WDFY4,ELMO1,DOCK2,IPCEF1
1.783e-02	-4.03	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	9	16828	45	PREX1,ARHGAP15,AKAP13,IPCEF1,DOCK2,WDFY4,ELMO1,SKAP1,PDE11A
1.786e-02	-4.03	MET activates PTPN11	REACTOME pathways	R-HSA-8865999	5	1	10285	37	GAB1
1.786e-02	-4.03	PTK6 Expression	REACTOME pathways	R-HSA-8849473	5	1	10285	37	HIF1A
1.788e-02	-4.02	KRTAP10-8 (keratin associated protein 10-8)	protein interactions	386681	399	4	19454	49	NEK6,ARHGAP33,DOCK2,P2RY6
1.793e-02	-4.02	HEMATOPO_REC_L_F3	prosite domains	PS01354	5	1	12186	44	IL6R
1.802e-02	-4.02	gastrointestinal_stromal_tumour	COSMIC cancer mutations	gastrointestinal_stromal_tumour	77	2	16828	45	NCK1,CSF1R
1.804e-02	-4.01	MHC class II protein binding	molecular function	GO:0042289	7	1	18094	47	CD74
1.804e-02	-4.01	interleukin-6 receptor binding	molecular function	GO:0005138	7	1	18094	47	IL6R
1.816e-02	-4.01	BLVRA (biliverdin reductase A)	protein interactions	644	82	2	19454	49	TLN1,PRKCD
1.816e-02	-4.01	GTF3C1 (general transcription factor IIIC subunit 1)	protein interactions	2975	221	3	19454	49	CD74,SYK,SKAP1
1.827e-02	-4.00	positive regulation of cell killing	biological process	GO:0031343	77	2	18204	49	VAV1,SYK
1.838e-02	-4.00	GAF	interpro domains	IPR003018	7	1	18521	49	PDE11A
1.838e-02	-4.00	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	49	TLN1
1.838e-02	-4.00	PH_16	interpro domains	IPR041020	7	1	18521	49	AKAP13
1.838e-02	-4.00	Vps9-like	interpro domains	IPR045046	7	1	18521	49	RIN3
1.838e-02	-4.00	Interferon_reg_factor-3	interpro domains	IPR019471	7	1	18521	49	IRF5
1.838e-02	-4.00	MYSc_Myo1	interpro domains	IPR036072	7	1	18521	49	MYO1F
1.838e-02	-4.00	CLTC (clathrin heavy chain)	protein interactions	1213	611	5	19454	49	RIN3,TLN1,PTAFR,APOE,EHBP1L1
1.844e-02	-3.99	negative regulation of phosphate metabolic process	biological process	GO:0045936	377	4	18204	49	PTPN6,NCK1,PRKCD,APOE
1.853e-02	-3.99	positive regulation of programmed cell death	biological process	GO:0043068	573	5	18204	49	PRKCD,SYK,NCK1,GSDME,IRF5
1.859e-02	-3.98	TGM1 (transglutaminase 1)	protein interactions	7051	223	3	19454	49	RIN3,TLN1,DOCK2
1.860e-02	-3.98	negative regulation of phosphorus metabolic process	biological process	GO:0010563	378	4	18204	49	PTPN6,NCK1,APOE,PRKCD
1.866e-02	-3.98	positive regulation of canonical NF-kappaB signal transduction	biological process	GO:0043123	209	3	18204	49	NEK6,AKAP13,CD74
1.869e-02	-3.98	positive regulation of interleukin-23 production	biological process	GO:0032747	7	1	18204	49	PLCG2
1.869e-02	-3.98	interleukin-3-mediated signaling pathway	biological process	GO:0038156	7	1	18204	49	SYK
1.869e-02	-3.98	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	49	APOE
1.869e-02	-3.98	positive regulation of sphingolipid biosynthetic process	biological process	GO:0090154	7	1	18204	49	PRKCD
1.869e-02	-3.98	regulation of macrophage proliferation	biological process	GO:0120040	7	1	18204	49	CSF1R
1.869e-02	-3.98	positive regulation of ceramide biosynthetic process	biological process	GO:2000304	7	1	18204	49	PRKCD
1.869e-02	-3.98	regulation of peptidyl-serine dephosphorylation	biological process	GO:1902308	7	1	18204	49	NCK1
1.869e-02	-3.98	neural fold formation	biological process	GO:0001842	7	1	18204	49	HIF1A
1.869e-02	-3.98	regulation of phospholipid catabolic process	biological process	GO:0060696	7	1	18204	49	PRKCD
1.869e-02	-3.98	positive regulation of glomerular mesangial cell proliferation	biological process	GO:0072126	7	1	18204	49	IL6R
1.869e-02	-3.98	positive regulation of gamma-delta T cell differentiation	biological process	GO:0045588	7	1	18204	49	SYK
1.869e-02	-3.98	citrulline metabolic process	biological process	GO:0000052	7	1	18204	49	ASS1
1.869e-02	-3.98	regulation of arachidonic acid secretion	biological process	GO:0090237	7	1	18204	49	SYK
1.869e-02	-3.98	response to yeast	biological process	GO:0001878	7	1	18204	49	PLCG2
1.869e-02	-3.98	positive regulation of dendritic cell antigen processing and presentation	biological process	GO:0002606	7	1	18204	49	CD74
1.869e-02	-3.98	wound healing involved in inflammatory response	biological process	GO:0002246	7	1	18204	49	HIF1A
1.869e-02	-3.98	platelet degranulation	biological process	GO:0002576	7	1	18204	49	SYK
1.869e-02	-3.98	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	49	APOE
1.869e-02	-3.98	connective tissue replacement	biological process	GO:0097709	7	1	18204	49	HIF1A
1.869e-02	-3.98	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	49	APOE
1.869e-02	-3.98	membrane raft localization	biological process	GO:0051665	7	1	18204	49	DOCK2
1.869e-02	-3.98	positive regulation of activation of Janus kinase activity	biological process	GO:0010536	7	1	18204	49	IL6R
1.869e-02	-3.98	macropinocytosis	biological process	GO:0044351	7	1	18204	49	DOCK2
1.872e-02	-3.98	negative regulation of tumor necrosis factor production	biological process	GO:0032720	78	2	18204	49	PTPN6,VSIR
1.872e-02	-3.98	regulation of protein dephosphorylation	biological process	GO:0035304	78	2	18204	49	NCK1,PRKCD
1.872e-02	-3.98	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	2	18204	49	P2RY6,PTAFR
1.872e-02	-3.98	neural crest cell development	biological process	GO:0014032	78	2	18204	49	HIF1A,SEMA4A
1.877e-02	-3.98	PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2)	protein interactions	5708	405	4	19454	49	P2RY6,PTPN6,VAV1,NEK6
1.881e-02	-3.97	clathrin-coated vesicle	cellular component	GO:0030136	220	3	19108	49	CD74,DENND1B,APOE
1.900e-02	-3.96	PER1 (period circadian regulator 1)	protein interactions	5187	84	2	19454	49	HIF1A,SKAP1
1.900e-02	-3.96	PPARA (peroxisome proliferator activated receptor alpha)	protein interactions	5465	84	2	19454	49	PRKCD,AKAP13
1.900e-02	-3.96	PHLDB3 (pleckstrin homology like domain family B member 3)	protein interactions	653583	84	2	19454	49	SKAP1,GIT2
1.900e-02	-3.96	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	49	SYK,CSF1R
1.904e-02	-3.96	JPH1 (junctophilin 1)	protein interactions	56704	225	3	19454	49	RHBDF2,SKAP1,CSF1R
1.912e-02	-3.96	IRF-3	pfam domains	PF10401	7	1	17795	49	IRF5
1.912e-02	-3.96	PH_16	pfam domains	PF17838	7	1	17795	49	AKAP13
1.912e-02	-3.96	GAF	pfam domains	PF01590	7	1	17795	49	PDE11A
1.917e-02	-3.95	positive regulation of blood vessel endothelial cell migration	biological process	GO:0043536	79	2	18204	49	GAB1,HIF1A
1.922e-02	-3.95	receptor tyrosine kinase binding	molecular function	GO:0030971	82	2	18094	47	BLNK,NCK1
1.933e-02	-3.95	I/LWEQ domain	gene3d domains	1.20.1410.10	6	1	14470	47	TLN1
1.943e-02	-3.94	MYD88 (MYD88 innate immune signal transduction adaptor)	protein interactions	4615	85	2	19454	49	IRF5,SYK
1.943e-02	-3.94	ZAP70 (zeta chain of T cell receptor associated protein kinase 70)	protein interactions	7535	85	2	19454	49	VAV1,PTPN6
1.948e-02	-3.94	PRKCD (protein kinase C delta)	protein interactions	5580	227	3	19454	49	ADCY7,PRKCD,PTPN6
1.963e-02	-3.93	regulation of cytokine production involved in inflammatory response	biological process	GO:1900015	80	2	18204	49	ADCY7,HIF1A
1.963e-02	-3.93	negative regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903556	80	2	18204	49	PTPN6,VSIR
1.986e-02	-3.92	WAS (WASP actin nucleation promoting factor)	protein interactions	7454	86	2	19454	49	FYB1,NCK1
1.993e-02	-3.92	PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)	protein interactions	5110	229	3	19454	49	AKAP13,RIN3,APOE
1.998e-02	-3.91	vIRF-3 (vIRF-3)	protein interactions	4961493	8	1	19454	49	HIF1A
1.998e-02	-3.91	SSX4 (SSX family member 4)	protein interactions	6759	8	1	19454	49	HIF1A
1.998e-02	-3.91	CD1D (CD1d molecule)	protein interactions	912	8	1	19454	49	CD74
1.998e-02	-3.91	TREML1 (triggering receptor expressed on myeloid cells like 1)	protein interactions	340205	8	1	19454	49	PTPN6
1.998e-02	-3.91	HIF3A (hypoxia inducible factor 3 subunit alpha)	protein interactions	64344	8	1	19454	49	HIF1A
1.998e-02	-3.91	RNPEPL1 (arginyl aminopeptidase like 1)	protein interactions	57140	8	1	19454	49	RIN3
1.998e-02	-3.91	LILRB1 (leukocyte immunoglobulin like receptor B1)	protein interactions	10859	8	1	19454	49	PTPN6
1.998e-02	-3.91	Dok1 (docking protein 1)	protein interactions	13448	8	1	19454	49	NCK1
1.998e-02	-3.91	Marcks (myristoylated alanine rich protein kinase C substrate)	protein interactions	17118	8	1	19454	49	PRKCD
1.998e-02	-3.91	MPC1 (mitochondrial pyruvate carrier 1)	protein interactions	51660	8	1	19454	49	ASS1
1.998e-02	-3.91	CDH6 (cadherin 6)	protein interactions	1004	8	1	19454	49	CDH18
1.998e-02	-3.91	Prkca (protein kinase C, alpha)	protein interactions	24680	8	1	19454	49	AKAP13
2.009e-02	-3.91	regulation of amide metabolic process	biological process	GO:0034248	81	2	18204	49	APOE,PRKCD
2.027e-02	-3.90	Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME pathways	R-HSA-881907	443	5	10285	37	PRKCD,P2RY2,P2RY6,PTAFR,TLN1
2.034e-02	-3.90	cell body fiber	cellular component	GO:0070852	8	1	19108	49	ASS1
2.056e-02	-3.88	antioxidant activity	molecular function	GO:0016209	85	2	18094	47	APOE,IPCEF1
2.059e-02	-3.88	positive regulation of cellular catabolic process	biological process	GO:0031331	217	3	18204	49	HIF1A,APOE,PRKCD
2.060e-02	-3.88	CD4 receptor binding	molecular function	GO:0042609	8	1	18094	47	CD74
2.060e-02	-3.88	transcription regulator activator activity	molecular function	GO:0140537	8	1	18094	47	HIF1A
2.060e-02	-3.88	adenosine receptor binding	molecular function	GO:0031685	8	1	18094	47	P2RY2
2.062e-02	-3.88	BCR (BCR activator of RhoGEF and GTPase)	protein interactions	613	232	3	19454	49	VAV1,HIF1A,PTPN6
2.084e-02	-3.87	response to ketone	biological process	GO:1901654	218	3	18204	49	PTAFR,P2RY6,ASS1
2.088e-02	-3.87	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	39	16828	45	RIN3,PLCG2,AKAP13,VAV1,P2RY2,HIF1A,BLNK,CSF1R,NCK1,PDE11A,GMIP,DENND1B,SBNO2,ARAP1,DOCK2,PTAFR,GIT2,SYK,EHBP1L1,PRKCD,WDFY4,GAB1,SKAP1,ADCY7,IPCEF1,ASS1,NEK6,ARHGAP15,CD74,MYO1F,IRF5,PREX1,PIK3R5,ELMO1,RHBDF2,ARHGAP33,CDH18,PARVG,PTPN6
2.097e-02	-3.86	Adcy	interpro domains	IPR030672	8	1	18521	49	ADCY7
2.097e-02	-3.86	Tyr_kinase_rcpt_3_CS	interpro domains	IPR001824	8	1	18521	49	CSF1R
2.097e-02	-3.86	Myosin_TH1	interpro domains	IPR010926	8	1	18521	49	MYO1F
2.097e-02	-3.86	GAF-like_dom_sf	interpro domains	IPR029016	8	1	18521	49	PDE11A
2.097e-02	-3.86	PH-BEACH_dom	interpro domains	IPR023362	8	1	18521	49	WDFY4
2.097e-02	-3.86	bMERB_dom	interpro domains	IPR022735	8	1	18521	49	EHBP1L1
2.097e-02	-3.86	AC_N	interpro domains	IPR032628	8	1	18521	49	ADCY7
2.097e-02	-3.86	TypeI_recpt_CBD	interpro domains	IPR015321	8	1	18521	49	IL6R
2.103e-02	-3.86	positive regulation of B cell activation	biological process	GO:0050871	83	2	18204	49	SYK,CD74
2.114e-02	-3.86	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	41	16828	45	GMIP,BLNK,NCK1,PDE11A,CSF1R,HIF1A,VAV1,P2RY2,AKAP13,RIN3,PLCG2,DOCK2,ARAP1,SBNO2,IL6R,DENND1B,GAB1,WDFY4,SKAP1,ADCY7,TLN1,PRKCD,P2RY6,APOE,EHBP1L1,SYK,SEMA4A,GIT2,PTPN6,PARVG,CDH18,PIK3R5,ELMO1,RHBDF2,ARHGAP33,PREX1,CD74,MYO1F,IRF5,NEK6,ARHGAP15
2.115e-02	-3.86	supramolecular fiber organization	biological process	GO:0097435	593	5	18204	49	PREX1,MYO1F,ELMO1,NCK1,ARAP1
2.117e-02	-3.85	FCER1G (Fc epsilon receptor Ig)	protein interactions	2207	89	2	19454	49	PLCG2,SYK
2.117e-02	-3.85	INSRR (insulin receptor related receptor)	protein interactions	3645	89	2	19454	49	RHBDF2,PRKCD
2.120e-02	-3.85	haematopoietic_and_lymphoid_tissue-other-normal	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-other-normal	8	1	16828	45	CSF1R
2.134e-02	-3.85	regulation of endodeoxyribonuclease activity	biological process	GO:0032071	8	1	18204	49	PRKCD
2.134e-02	-3.85	positive regulation of killing of cells of another organism	biological process	GO:0051712	8	1	18204	49	SYK
2.134e-02	-3.85	negative regulation of CD8-positive, alpha-beta T cell activation	biological process	GO:2001186	8	1	18204	49	VSIR
2.134e-02	-3.85	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	49	APOE
2.134e-02	-3.85	regulation of transforming growth factor beta2 production	biological process	GO:0032909	8	1	18204	49	HIF1A
2.134e-02	-3.85	cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:0036006	8	1	18204	49	CSF1R
2.134e-02	-3.85	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	49	APOE
2.134e-02	-3.85	regulation of CD8-positive, alpha-beta T cell proliferation	biological process	GO:2000564	8	1	18204	49	VSIR
2.134e-02	-3.85	aspartate metabolic process	biological process	GO:0006531	8	1	18204	49	ASS1
2.134e-02	-3.85	positive regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001280	8	1	18204	49	CD74
2.134e-02	-3.85	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	49	APOE
2.134e-02	-3.85	regulation of mast cell chemotaxis	biological process	GO:0060753	8	1	18204	49	RIN3
2.134e-02	-3.85	cellular response to laminar fluid shear stress	biological process	GO:0071499	8	1	18204	49	ASS1
2.134e-02	-3.85	multinuclear osteoclast differentiation	biological process	GO:0072674	8	1	18204	49	SBNO2
2.134e-02	-3.85	mitotic nuclear membrane disassembly	biological process	GO:0007077	8	1	18204	49	NEK6
2.134e-02	-3.85	regulation of activation of Janus kinase activity	biological process	GO:0010533	8	1	18204	49	IL6R
2.134e-02	-3.85	G protein-coupled receptor signaling pathway involved in heart process	biological process	GO:0086103	8	1	18204	49	AKAP13
2.134e-02	-3.85	signal complex assembly	biological process	GO:0007172	8	1	18204	49	NCK1
2.134e-02	-3.85	protein import	biological process	GO:0017038	8	1	18204	49	APOE
2.134e-02	-3.85	regulation of I-kappaB phosphorylation	biological process	GO:1903719	8	1	18204	49	PLCG2
2.134e-02	-3.85	regulation of cytoplasmic translational initiation	biological process	GO:1904688	8	1	18204	49	NCK1
2.134e-02	-3.85	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	49	APOE
2.134e-02	-3.85	intracellular oxygen homeostasis	biological process	GO:0032364	8	1	18204	49	HIF1A
2.140e-02	-3.84	CD22 mediated BCR regulation	REACTOME pathways	R-HSA-5690714	6	1	10285	37	PTPN6
2.140e-02	-3.84	PTK6 promotes HIF1A stabilization	REACTOME pathways	R-HSA-8857538	6	1	10285	37	HIF1A
2.140e-02	-3.84	MET activates PI3K/AKT signaling	REACTOME pathways	R-HSA-8851907	6	1	10285	37	GAB1
2.147e-02	-3.84	ELMO	prosite domains	PS51335	6	1	12186	44	ELMO1
2.151e-02	-3.84	stem cell development	biological process	GO:0048864	84	2	18204	49	HIF1A,SEMA4A
2.151e-02	-3.84	regulation of release of sequestered calcium ion into cytosol	biological process	GO:0051279	84	2	18204	49	P2RY6,PTPN6
2.159e-02	-3.84	regulation of cell-substrate adhesion	biological process	GO:0010810	221	3	18204	49	PREX1,SKAP1,TLN1
2.162e-02	-3.83	IPO13 (importin 13)	protein interactions	9670	90	2	19454	49	CD74,P2RY6
2.180e-02	-3.83	PPP6R3 (protein phosphatase 6 regulatory subunit 3)	protein interactions	55291	237	3	19454	49	IRF5,P2RY6,CD74
2.182e-02	-3.82	Myosin_TH1	pfam domains	PF06017	8	1	17795	49	MYO1F
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY7
2.182e-02	-3.82	bMERB_dom	pfam domains	PF12130	8	1	17795	49	EHBP1L1
2.182e-02	-3.82	IL6Ra-bind	pfam domains	PF09240	8	1	17795	49	IL6R
2.207e-02	-3.81	KDELR1 (KDEL endoplasmic reticulum protein retention receptor 1)	protein interactions	10945	91	2	19454	49	P2RY2,NEK6
2.207e-02	-3.81	TKFC (triokinase and FMN cyclase)	protein interactions	26007	91	2	19454	49	ASS1,AKAP13
2.207e-02	-3.81	TMEM259 (transmembrane protein 259)	protein interactions	91304	91	2	19454	49	PTAFR,P2RY2
2.227e-02	-3.80	human chr6q25.2	chromosome location	human chr6q25.2	12	1	26134	49	IPCEF1
2.230e-02	-3.80	STAT3 (signal transducer and activator of transcription 3)	protein interactions	6774	427	4	19454	49	IL6R,SYK,PRKCD,HIF1A
2.241e-02	-3.80	phosphoric diester hydrolase activity	molecular function	GO:0008081	89	2	18094	47	PDE11A,PLCG2
2.241e-02	-3.80	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	47	CD74,APOE
2.245e-02	-3.80	LILRB2 (leukocyte immunoglobulin like receptor B2)	protein interactions	10288	9	1	19454	49	PTPN6
2.245e-02	-3.80	ARHGAP33 (Rho GTPase activating protein 33)	protein interactions	115703	9	1	19454	49	NEK6
2.245e-02	-3.80	DUX3 (double homeobox 3)	protein interactions	26582	9	1	19454	49	PRKCD
2.245e-02	-3.80	RWDD3 (RWD domain containing 3)	protein interactions	25950	9	1	19454	49	HIF1A
2.245e-02	-3.80	PEAR1 (platelet endothelial aggregation receptor 1)	protein interactions	375033	9	1	19454	49	SYK
2.245e-02	-3.80	HLA-DMA (major histocompatibility complex, class II, DM alpha)	protein interactions	3108	9	1	19454	49	CD74
2.245e-02	-3.80	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	49	APOE
2.245e-02	-3.80	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	49	APOE
2.245e-02	-3.80	ADCY7 (adenylate cyclase 7)	protein interactions	113	9	1	19454	49	PRKCD
2.247e-02	-3.80	response to cAMP	biological process	GO:0051591	86	2	18204	49	ASS1,PTAFR
2.247e-02	-3.80	positive regulation of lipid transport	biological process	GO:0032370	86	2	18204	49	APOE,PRKCD
2.247e-02	-3.80	HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta)	protein interactions	3032	428	4	19454	49	P2RY6,SYK,APOE,CD74
2.253e-02	-3.79	MLEC (malectin)	protein interactions	9761	92	2	19454	49	P2RY6,RIN3
2.253e-02	-3.79	ARHGEF16 (Rho guanine nucleotide exchange factor 16)	protein interactions	27237	92	2	19454	49	PRKCD,ELMO1
2.265e-02	-3.79	Differentiation Pathway	WikiPathways	WP2848	48	2	5310	26	IL6R,CSF1R
2.272e-02	-3.78	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	37	GAB1,VAV1
2.277e-02	-3.78	TIMM50 (translocase of inner mitochondrial membrane 50)	protein interactions	92609	241	3	19454	49	HIF1A,VAV1,RIN3
2.285e-02	-3.78	unconventional myosin complex	cellular component	GO:0016461	9	1	19108	49	MYO1F
2.285e-02	-3.78	phosphatidylinositol 3-kinase complex, class I	cellular component	GO:0097651	9	1	19108	49	PIK3R5
2.285e-02	-3.78	phosphatidylinositol 3-kinase complex, class IA	cellular component	GO:0005943	9	1	19108	49	PIK3R5
2.296e-02	-3.77	modulation by host of symbiont process	biological process	GO:0051851	87	2	18204	49	CSF1R,APOE
2.299e-02	-3.77	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	49	NCK1,GIT2
2.299e-02	-3.77	RTEL1 (regulator of telomere elongation helicase 1)	protein interactions	51750	93	2	19454	49	SKAP1,NCK1
2.299e-02	-3.77	USP25 (ubiquitin specific peptidase 25)	protein interactions	29761	93	2	19454	49	SYK,HIF1A
2.302e-02	-3.77	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	7	19454	49	GAB1,APOE,CD74,DENND1B,PRKCD,RIN3,AKAP13
2.314e-02	-3.77	angiotensin receptor binding	molecular function	GO:0031701	9	1	18094	47	ARAP1
2.316e-02	-3.77	SMAD3 (SMAD family member 3)	protein interactions	4088	432	4	19454	49	VSIR,HIF1A,PTPN6,GIT2
2.332e-02	-3.76	intracellular vesicle	cellular component	GO:0097708	2527	12	19108	49	PTPN6,APOE,PTAFR,EHBP1L1,CD74,DOCK2,PLCG2,RIN3,SYK,WDFY4,PRKCD,DENND1B
2.345e-02	-3.75	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	49	PTAFR,ELMO1
2.346e-02	-3.75	regulation of tissue remodeling	biological process	GO:0034103	88	2	18204	49	SYK,CSF1R
2.357e-02	-3.75	Interferon_reg_fac_CS	interpro domains	IPR019817	9	1	18521	49	IRF5
2.357e-02	-3.75	BEACH_dom_sf	interpro domains	IPR036372	9	1	18521	49	WDFY4
2.357e-02	-3.75	Peptidase_S54_rhomboid_dom	interpro domains	IPR022764	9	1	18521	49	RHBDF2
2.357e-02	-3.75	BEACH_dom	interpro domains	IPR000409	9	1	18521	49	WDFY4
2.357e-02	-3.75	Interferon_reg_fact_DNA-bd_dom	interpro domains	IPR001346	9	1	18521	49	IRF5
2.376e-02	-3.74	clathrin-coated endocytic vesicle	cellular component	GO:0045334	93	2	19108	49	CD74,APOE
2.395e-02	-3.73	regulation of leukocyte apoptotic process	biological process	GO:2000106	89	2	18204	49	HIF1A,CD74
2.395e-02	-3.73	negative regulation of lymphocyte proliferation	biological process	GO:0050672	89	2	18204	49	PTPN6,VSIR
2.397e-02	-3.73	regulation of gamma-delta T cell differentiation	biological process	GO:0045586	9	1	18204	49	SYK
2.397e-02	-3.73	iris morphogenesis	biological process	GO:0061072	9	1	18204	49	HIF1A
2.397e-02	-3.73	positive regulation of T-helper 2 cell cytokine production	biological process	GO:2000553	9	1	18204	49	DENND1B
2.397e-02	-3.73	transepithelial chloride transport	biological process	GO:0030321	9	1	18204	49	P2RY6
2.397e-02	-3.73	gamma-delta T cell differentiation	biological process	GO:0042492	9	1	18204	49	SYK
2.397e-02	-3.73	sterol catabolic process	biological process	GO:0016127	9	1	18204	49	APOE
2.397e-02	-3.73	positive regulation of hormone biosynthetic process	biological process	GO:0046886	9	1	18204	49	HIF1A
2.397e-02	-3.73	establishment of T cell polarity	biological process	GO:0001768	9	1	18204	49	DOCK2
2.397e-02	-3.73	macrophage proliferation	biological process	GO:0061517	9	1	18204	49	CSF1R
2.397e-02	-3.73	microglial cell proliferation	biological process	GO:0061518	9	1	18204	49	CSF1R
2.397e-02	-3.73	regulation of mucus secretion	biological process	GO:0070255	9	1	18204	49	P2RY2
2.397e-02	-3.73	positive regulation of antigen processing and presentation	biological process	GO:0002579	9	1	18204	49	CD74
2.397e-02	-3.73	glandular epithelial cell maturation	biological process	GO:0002071	9	1	18204	49	HIF1A
2.397e-02	-3.73	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	biological process	GO:1902237	9	1	18204	49	NCK1
2.397e-02	-3.73	cellular response to hydroperoxide	biological process	GO:0071447	9	1	18204	49	PRKCD
2.397e-02	-3.73	regulation of killing of cells of another organism	biological process	GO:0051709	9	1	18204	49	SYK
2.397e-02	-3.73	substrate-dependent cell migration, cell extension	biological process	GO:0006930	9	1	18204	49	NCK1
2.397e-02	-3.73	negative regulation of cAMP-mediated signaling	biological process	GO:0043951	9	1	18204	49	PDE11A
2.397e-02	-3.73	regulation of sarcomere organization	biological process	GO:0060297	9	1	18204	49	AKAP13
2.397e-02	-3.73	positive regulation of cell proliferation involved in kidney development	biological process	GO:1901724	9	1	18204	49	IL6R
2.397e-02	-3.73	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	49	APOE
2.397e-02	-3.73	negative regulation of inflammatory response to wounding	biological process	GO:0106015	9	1	18204	49	PTPN6
2.397e-02	-3.73	negative regulation of thymocyte apoptotic process	biological process	GO:0070244	9	1	18204	49	HIF1A
2.397e-02	-3.73	diaphragm development	biological process	GO:0060539	9	1	18204	49	ASS1
2.397e-02	-3.73	T-helper 17 cell lineage commitment	biological process	GO:0072540	9	1	18204	49	IL6R
2.397e-02	-3.73	positive regulation of gamma-delta T cell activation	biological process	GO:0046645	9	1	18204	49	SYK
2.397e-02	-3.73	response to gravity	biological process	GO:0009629	9	1	18204	49	PTAFR
2.438e-02	-3.71	KCTD5 (potassium channel tetramerization domain containing 5)	protein interactions	54442	96	2	19454	49	GIT2,NEK6
2.439e-02	-3.71	GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)	protein interactions	8729	439	4	19454	49	HIF1A,PTPN6,GSDME,TLN1
2.446e-02	-3.71	regulation of Rho protein signal transduction	biological process	GO:0035023	90	2	18204	49	APOE,AKAP13
2.452e-02	-3.71	Beach	pfam domains	PF02138	9	1	17795	49	WDFY4
2.452e-02	-3.71	Rhomboid	pfam domains	PF01694	9	1	17795	49	RHBDF2
2.452e-02	-3.71	IRF	pfam domains	PF00605	9	1	17795	49	IRF5
2.452e-02	-3.71	ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)	protein interactions	25	248	3	19454	49	VAV1,NCK1,PTPN6
2.462e-02	-3.70	LPA receptor mediated events	Pathway Interaction DB	lysophospholipid_pathway	65	3	2226	22	GAB1,PRKCD,ADCY7
2.472e-02	-3.70	Semaphorin interactions	REACTOME pathways	R-HSA-373755	68	2	10285	37	SEMA4A,TLN1
2.476e-02	-3.70	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	6	16828	45	ASS1,NEK6,ARHGAP15,SEMA4A,ELMO1,DOCK2
2.486e-02	-3.69	SOCS3 (suppressor of cytokine signaling 3)	protein interactions	9021	97	2	19454	49	GAB1,CSF1R
2.491e-02	-3.69	NRAP (nebulin related anchoring protein)	protein interactions	4892	10	1	19454	49	TLN1
2.491e-02	-3.69	RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1)	protein interactions	9649	10	1	19454	49	NCK1
2.491e-02	-3.69	PGA4 (pepsinogen A4)	protein interactions	643847	10	1	19454	49	CD74
2.491e-02	-3.69	IL11 (interleukin 11)	protein interactions	3589	10	1	19454	49	HIF1A
2.491e-02	-3.69	GPLD1 (glycosylphosphatidylinositol specific phospholipase D1)	protein interactions	2822	10	1	19454	49	HIF1A
2.491e-02	-3.69	SIGLEC7 (sialic acid binding Ig like lectin 7)	protein interactions	27036	10	1	19454	49	PTPN6
2.491e-02	-3.69	SIGLEC10 (sialic acid binding Ig like lectin 10)	protein interactions	89790	10	1	19454	49	PTPN6
2.492e-02	-3.69	Activation of NIMA Kinases NEK9, NEK6, NEK7	REACTOME pathways	R-HSA-2980767	7	1	10285	37	NEK6
2.496e-02	-3.69	negative regulation of mononuclear cell proliferation	biological process	GO:0032945	91	2	18204	49	VSIR,PTPN6
2.496e-02	-3.69	cellular oxidant detoxification	biological process	GO:0098869	91	2	18204	49	APOE,IPCEF1
2.496e-02	-3.69	neural crest cell differentiation	biological process	GO:0014033	91	2	18204	49	SEMA4A,HIF1A
2.530e-02	-3.68	protein transport	biological process	GO:0015031	1086	7	18204	49	APOE,CD74,SYK,ARHGAP33,DENND1B,RHBDF2,HIF1A
2.534e-02	-3.68	TM9SF4 (transmembrane 9 superfamily member 4)	protein interactions	9777	98	2	19454	49	PTAFR,P2RY2
2.534e-02	-3.68	SERPINA12 (serpin family A member 12)	protein interactions	145264	98	2	19454	49	DENND1B,VAV1
2.534e-02	-3.68	EPHX1 (epoxide hydrolase 1)	protein interactions	2052	98	2	19454	49	PTAFR,ASS1
2.534e-02	-3.68	PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2)	protein interactions	5636	98	2	19454	49	VAV1,NCK1
2.534e-02	-3.68	NUDT16L1 (nudix hydrolase 16 like 1)	protein interactions	84309	98	2	19454	49	NEK6,RIN3
2.534e-02	-3.68	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	2	19454	49	GAB1,NCK1
2.534e-02	-3.68	VAV2 (vav guanine nucleotide exchange factor 2)	protein interactions	7410	98	2	19454	49	SYK,GAB1
2.534e-02	-3.68	Ion Channel and Phorbal Esters Signaling Pathway	SMPDB pathways	SMP0090032	5	1	1369	7	P2RY2
2.536e-02	-3.67	immunoglobulin complex	cellular component	GO:0019814	10	1	19108	49	SYK
2.538e-02	-3.67	Hepatitis C and Hepatocellular Carcinoma	WikiPathways	WP3646	51	2	5310	26	HIF1A,IL6R
2.540e-02	-3.67	Interferon alpha/beta signaling	REACTOME pathways	R-HSA-909733	69	2	10285	37	PTPN6,IRF5
2.540e-02	-3.67	Costimulation by the CD28 family	REACTOME pathways	R-HSA-388841	69	2	10285	37	PTPN6,VAV1
2.542e-02	-3.67	programmed cell death	biological process	GO:0012501	1087	7	18204	49	NEK6,HIF1A,ELMO1,GSDME,PLCG2,IL6R,PRKCD
2.548e-02	-3.67	positive regulation of transporter activity	biological process	GO:0032411	92	2	18204	49	P2RY6,PRKCD
2.548e-02	-3.67	alcohol biosynthetic process	biological process	GO:0046165	92	2	18204	49	PLCG2,PTAFR
2.548e-02	-3.67	central_nervous_system-brain-glioma-astrocytoma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_II	420	4	16828	45	WDFY4,SBNO2,TLN1,PREX1
2.555e-02	-3.67	CSDE1 (cold shock domain containing E1)	protein interactions	7812	252	3	19454	49	RHBDF2,RIN3,P2RY6
2.555e-02	-3.67	PSMD7 (proteasome 26S subunit, non-ATPase 7)	protein interactions	5713	252	3	19454	49	PREX1,P2RY6,PTPN6
2.555e-02	-3.67	CXCR4 (C-X-C motif chemokine receptor 4)	protein interactions	7852	252	3	19454	49	HIF1A,PTPN6,VAV1
2.566e-02	-3.66	cell differentiation	biological process	GO:0030154	3645	16	18204	49	DOCK2,CD74,PREX1,PLCG2,AKAP13,IL6R,VAV1,CSF1R,HIF1A,BLNK,SBNO2,PTPN6,GSDME,SYK,APOE,SEMA4A
2.568e-02	-3.66	toxic substance binding	molecular function	GO:0015643	10	1	18094	47	ASS1
2.570e-02	-3.66	-	gene3d domains	3.30.450.40	8	1	14470	47	PDE11A
2.570e-02	-3.66	Urea cycle	KEGG pathways	M00029	6	1	7161	31	ASS1
2.570e-02	-3.66	Urea cycle	KEGG pathways	hsa_M00029	6	1	7161	31	ASS1
2.582e-02	-3.66	PRPSAP1 (phosphoribosyl pyrophosphate synthetase associated protein 1)	protein interactions	5635	99	2	19454	49	NCK1,VAV1
2.582e-02	-3.66	XPO4 (exportin 4)	protein interactions	64328	99	2	19454	49	P2RY6,P2RY2
2.584e-02	-3.66	cellular developmental process	biological process	GO:0048869	3648	16	18204	49	SEMA4A,APOE,SYK,GSDME,PTPN6,SBNO2,BLNK,HIF1A,CSF1R,VAV1,IL6R,AKAP13,PLCG2,PREX1,CD74,DOCK2
2.587e-02	-3.65	cell death	biological process	GO:0008219	1091	7	18204	49	NEK6,ELMO1,GSDME,PLCG2,IL6R,PRKCD,HIF1A
2.589e-02	-3.65	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	31	16828	45	PLCG2,RIN3,AKAP13,VAV1,P2RY2,BLNK,CSF1R,PDE11A,NCK1,DOCK2,SYK,APOE,PRKCD,TLN1,P2RY6,WDFY4,GAB1,SKAP1,ADCY7,IPCEF1,NEK6,ARHGAP15,IRF5,MYO1F,PREX1,ELMO1,PIK3R5,ARHGAP33,RHBDF2,CDH18,PTPN6
2.594e-02	-3.65	human chr9q22.2	chromosome location	human chr9q22.2	14	1	26134	49	SYK
2.599e-02	-3.65	polyol metabolic process	biological process	GO:0019751	93	2	18204	49	PLCG2,PTAFR
2.615e-02	-3.64	VPS9	interpro domains	IPR003123	10	1	18521	49	RIN3
2.615e-02	-3.64	VPS9_dom_sf	interpro domains	IPR037191	10	1	18521	49	RIN3
2.615e-02	-3.64	PAS_fold_3	interpro domains	IPR013655	10	1	18521	49	HIF1A
2.616e-02	-3.64	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	49	RHBDF2,SKAP1,FYB1
2.619e-02	-3.64	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	49	SYK,CSF1R
2.621e-02	-3.64	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	633	5	16828	45	RHBDF2,AKAP13,CDH18,PREX1,P2RY2
2.630e-02	-3.64	cytokine receptor activity	molecular function	GO:0004896	97	2	18094	47	CD74,IL6R
2.630e-02	-3.64	PTK6 (protein tyrosine kinase 6)	protein interactions	5753	100	2	19454	49	HIF1A,GAB1
2.630e-02	-3.64	SKAP1 (src kinase associated phosphoprotein 1)	protein interactions	8631	100	2	19454	49	FYB1,SKAP1
2.634e-02	-3.64	CD79A (CD79a molecule)	protein interactions	973	255	3	19454	49	SYK,BLNK,PTPN6
2.634e-02	-3.64	MSH6 (mutS homolog 6)	protein interactions	2956	255	3	19454	49	HIF1A,P2RY6,RIN3
2.638e-02	-3.64	negative regulation of protein modification process	biological process	GO:0031400	421	4	18204	49	PTPN6,NCK1,PRKCD,APOE
2.651e-02	-3.63	regulation of calcium-mediated signaling	biological process	GO:0050848	94	2	18204	49	SYK,PLCG2
2.651e-02	-3.63	negative regulation of protein serine/threonine kinase activity	biological process	GO:0071901	94	2	18204	49	APOE,PRKCD
2.660e-02	-3.63	endothelial cell chemotaxis	biological process	GO:0035767	10	1	18204	49	GAB1
2.660e-02	-3.63	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	49	ADCY7
2.660e-02	-3.63	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	49	APOE
2.660e-02	-3.63	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	49	APOE
2.660e-02	-3.63	hemoglobin metabolic process	biological process	GO:0020027	10	1	18204	49	HIF1A
2.660e-02	-3.63	establishment of lymphocyte polarity	biological process	GO:0001767	10	1	18204	49	DOCK2
2.660e-02	-3.63	integrin activation	biological process	GO:0033622	10	1	18204	49	TLN1
2.660e-02	-3.63	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	49	APOE
2.660e-02	-3.63	regulation of deoxyribonuclease activity	biological process	GO:0032070	10	1	18204	49	PRKCD
2.660e-02	-3.63	negative regulation of mast cell activation	biological process	GO:0033004	10	1	18204	49	PTPN6
2.660e-02	-3.63	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	49	APOE
2.660e-02	-3.63	regulation of interleukin-23 production	biological process	GO:0032667	10	1	18204	49	PLCG2
2.660e-02	-3.63	regulation of translation in response to endoplasmic reticulum stress	biological process	GO:0036490	10	1	18204	49	NCK1
2.660e-02	-3.63	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	49	APOE
2.660e-02	-3.63	negative regulation of glial cell apoptotic process	biological process	GO:0034351	10	1	18204	49	PRKCD
2.660e-02	-3.63	positive regulation of monocyte differentiation	biological process	GO:0045657	10	1	18204	49	CD74
2.660e-02	-3.63	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	49	APOE
2.674e-02	-3.62	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	11	16828	45	DOCK2,ELMO1,SBNO2,ARHGAP15,SKAP1,GAB1,BLNK,WDFY4,NCK1,TLN1,AKAP13
2.674e-02	-3.62	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	11	16828	45	AKAP13,ARHGAP15,DOCK2,BLNK,ELMO1,SKAP1,GAB1,WDFY4,SBNO2,NCK1,TLN1
2.679e-02	-3.62	FBXO28 (F-box protein 28)	protein interactions	23219	101	2	19454	49	GIT2,HIF1A
2.679e-02	-3.62	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	49	RHBDF2,PTPN6
2.679e-02	-3.62	BMAL1 (basic helix-loop-helix ARNT like 1)	protein interactions	406	101	2	19454	49	GIT2,HIF1A
2.679e-02	-3.62	MYO9B (myosin IXB)	protein interactions	4650	101	2	19454	49	HIF1A,SKAP1
2.697e-02	-3.61	JUP (junction plakoglobin)	protein interactions	3728	453	4	19454	49	HIF1A,GAB1,NCK1,TLN1
2.715e-02	-3.61	SMC4 (structural maintenance of chromosomes 4)	protein interactions	10051	258	3	19454	49	P2RY6,VAV1,RIN3
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	HIF1A
2.720e-02	-3.60	VPS9	pfam domains	PF02204	10	1	17795	49	RIN3
2.728e-02	-3.60	DOCK5 (dedicator of cytokinesis 5)	protein interactions	80005	102	2	19454	49	GIT2,ELMO1
2.728e-02	-3.60	TMEM97 (transmembrane protein 97)	protein interactions	27346	102	2	19454	49	CD74,VSIR
2.728e-02	-3.60	FASLG (Fas ligand)	protein interactions	356	102	2	19454	49	NCK1,FYB1
2.737e-02	-3.60	CYP1A2 (cytochrome P450 family 1 subfamily A member 2)	protein interactions	1544	11	1	19454	49	HIF1A
2.737e-02	-3.60	SPATA12 (spermatogenesis associated 12)	protein interactions	353324	11	1	19454	49	RIN3
2.737e-02	-3.60	RPS10-NUDT3 (RPS10-NUDT3 readthrough)	protein interactions	100529239	11	1	19454	49	RIN3
2.737e-02	-3.60	GHSR (growth hormone secretagogue receptor)	protein interactions	2693	11	1	19454	49	P2RY6
2.737e-02	-3.60	ADGRG2 (adhesion G protein-coupled receptor G2)	protein interactions	10149	11	1	19454	49	GMIP
2.737e-02	-3.60	Caskin1 (CASK interacting protein 1)	protein interactions	140722	11	1	19454	49	NCK1
2.737e-02	-3.60	FERRY3 (FERRY endosomal RAB5 effector complex subunit 3)	protein interactions	57102	11	1	19454	49	IL6R
2.737e-02	-3.60	LAX1 (lymphocyte transmembrane adaptor 1)	protein interactions	54900	11	1	19454	49	SYK
2.737e-02	-3.60	FMO1 (flavin containing dimethylaniline monoxygenase 1)	protein interactions	2326	11	1	19454	49	TLN1
2.737e-02	-3.60	RGCC (regulator of cell cycle)	protein interactions	28984	11	1	19454	49	TLN1
2.737e-02	-3.60	KLHL32 (kelch like family member 32)	protein interactions	114792	11	1	19454	49	PARVG
2.737e-02	-3.60	NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1)	protein interactions	222950	11	1	19454	49	TLN1
2.737e-02	-3.60	response to lipid	biological process	GO:0033993	862	6	18204	49	PLCG2,PTAFR,P2RY6,SBNO2,ASS1,SYK
2.748e-02	-3.59	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	45	SYK,NEK6,PRKCD,CSF1R
2.748e-02	-3.59	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	45	CSF1R,PRKCD,NEK6,SYK
2.756e-02	-3.59	immunoglobulin mediated immune response	biological process	GO:0016064	96	2	18204	49	CD74,PRKCD
2.769e-02	-3.59	ruffle membrane	cellular component	GO:0032587	101	2	19108	49	PLCG2,TLN1
2.777e-02	-3.58	human chr14q23.2	chromosome location	human chr14q23.2	15	1	26134	49	HIF1A
2.777e-02	-3.58	GAF	smart domains	SM00065	7	1	9717	39	PDE11A
2.777e-02	-3.58	IRF-3	smart domains	SM01243	7	1	9717	39	IRF5
2.778e-02	-3.58	PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1)	protein interactions	54704	103	2	19454	49	HIF1A,PRKCD
2.791e-02	-3.58	RIGI (RNA sensor RIG-I)	protein interactions	23586	1739	9	19454	49	RHBDF2,GIT2,GMIP,ARAP1,RIN3,SBNO2,PLCG2,PTPN6,MYO1F
2.821e-02	-3.57	nitric-oxide synthase binding	molecular function	GO:0050998	11	1	18094	47	CD74
2.821e-02	-3.57	T cell receptor binding	molecular function	GO:0042608	11	1	18094	47	DOCK2
2.821e-02	-3.57	cardiolipin binding	molecular function	GO:1901612	11	1	18094	47	GSDME
2.828e-02	-3.57	SLC25A22 (solute carrier family 25 member 22)	protein interactions	79751	104	2	19454	49	VAV1,HIF1A
2.828e-02	-3.57	GRK2 (G protein-coupled receptor kinase 2)	protein interactions	156	104	2	19454	49	PRKCD,GIT2
2.830e-02	-3.56	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	11	16828	45	AKAP13,NCK1,GAB1,BLNK,SKAP1,WDFY4,TLN1,ARHGAP15,DOCK2,SBNO2,ELMO1
2.832e-02	-3.56	IGF1R (insulin like growth factor 1 receptor)	protein interactions	3480	460	4	19454	49	PTPN6,PRKCD,GAB1,NCK1
2.843e-02	-3.56	HuR (ELAVL1) binds and stabilizes mRNA	REACTOME pathways	R-HSA-450520	8	1	10285	37	PRKCD
2.847e-02	-3.56	regulation of synapse organization	biological process	GO:0050807	246	3	18204	49	APOE,SEMA4A,ARHGAP33
2.849e-02	-3.56	protein binding	molecular function	GO:0005515	13983	42	18094	47	RIN3,PREX1,NEK6,FYB1,SEMA4A,PLCG2,IPCEF1,ARHGAP33,APOE,ASS1,GIT2,DENND1B,PRKCD,CD74,BLNK,AKAP13,IRF5,GAB1,SKAP1,MYO1F,SBNO2,ELMO1,PARVG,HIF1A,SYK,GMIP,RHBDF2,VSIR,IL6R,GSDME,P2RY6,CDH18,ARHGAP27,VAV1,PTAFR,P2RY2,CSF1R,PTPN6,ARAP1,NCK1,TLN1,DOCK2
2.853e-02	-3.56	RECEPTOR_TYR_KIN_III	prosite domains	PS00240	8	1	12186	44	CSF1R
2.853e-02	-3.56	PH_BEACH	prosite domains	PS51783	8	1	12186	44	WDFY4
2.853e-02	-3.56	BMERB	prosite domains	PS51848	8	1	12186	44	EHBP1L1
2.853e-02	-3.56	TH1	prosite domains	PS51757	8	1	12186	44	MYO1F
2.873e-02	-3.55	SM22_calponin	interpro domains	IPR003096	11	1	18521	49	VAV1
2.873e-02	-3.55	DOCKER_Lobe_C	interpro domains	IPR046773	11	1	18521	49	DOCK2
2.873e-02	-3.55	DOCK	interpro domains	IPR026791	11	1	18521	49	DOCK2
2.873e-02	-3.55	DOCKER_dom	interpro domains	IPR027357	11	1	18521	49	DOCK2
2.873e-02	-3.55	DOCKER_Lobe_A	interpro domains	IPR046769	11	1	18521	49	DOCK2
2.873e-02	-3.55	DOCK_C_lobe_A	interpro domains	IPR043161	11	1	18521	49	DOCK2
2.873e-02	-3.55	C2_DOCK-type_domain	interpro domains	IPR027007	11	1	18521	49	DOCK2
2.873e-02	-3.55	DOCKER_Lobe_B	interpro domains	IPR046770	11	1	18521	49	DOCK2
2.873e-02	-3.55	DOCK_C_lobe_C	interpro domains	IPR043162	11	1	18521	49	DOCK2
2.879e-02	-3.55	PCBP2 (poly(rC) binding protein 2)	protein interactions	5094	264	3	19454	49	HIF1A,P2RY6,RIN3
2.879e-02	-3.55	RCN2 (reticulocalbin 2)	protein interactions	5955	264	3	19454	49	P2RY6,RIN3,APOE
2.885e-02	-3.55	regulation of protein transport	biological process	GO:0051223	433	4	18204	49	RHBDF2,HIF1A,APOE,PRKCD
2.886e-02	-3.55	Nucleotidyltransferases domain 2	gene3d domains	1.20.120.330	9	1	14470	47	GIT2
2.886e-02	-3.55	BEACH domain	gene3d domains	1.10.1540.10	9	1	14470	47	WDFY4
2.907e-02	-3.54	OSBPL8 (oxysterol binding protein like 8)	protein interactions	114882	265	3	19454	49	SYK,CD74,P2RY6
2.908e-02	-3.54	small_intestine	COSMIC cancer mutations	small_intestine	250	3	16828	45	PREX1,CSF1R,ARHGAP33
2.917e-02	-3.53	regulation of signaling receptor activity	biological process	GO:0010469	99	2	18204	49	HIF1A,PRKCD
2.917e-02	-3.53	negative regulation of leukocyte proliferation	biological process	GO:0070664	99	2	18204	49	PTPN6,VSIR
2.921e-02	-3.53	Interferon type I signaling pathways	WikiPathways	WP585	55	2	5310	26	PTPN6,VAV1
2.922e-02	-3.53	CD8-positive, alpha-beta T cell activation	biological process	GO:0036037	11	1	18204	49	WDFY4
2.922e-02	-3.53	positive regulation of integrin activation	biological process	GO:0033625	11	1	18204	49	SKAP1
2.922e-02	-3.53	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	49	PRKCD
2.922e-02	-3.53	collagen-activated tyrosine kinase receptor signaling pathway	biological process	GO:0038063	11	1	18204	49	SYK
2.922e-02	-3.53	positive regulation of chemokine (C-X-C motif) ligand 2 production	biological process	GO:2000343	11	1	18204	49	CD74
2.922e-02	-3.53	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	49	APOE
2.922e-02	-3.53	regulation of gamma-delta T cell activation	biological process	GO:0046643	11	1	18204	49	SYK
2.922e-02	-3.53	negative regulation of mesenchymal cell apoptotic process	biological process	GO:2001054	11	1	18204	49	HIF1A
2.922e-02	-3.53	urea cycle	biological process	GO:0000050	11	1	18204	49	ASS1
2.922e-02	-3.53	regulation of PERK-mediated unfolded protein response	biological process	GO:1903897	11	1	18204	49	NCK1
2.922e-02	-3.53	regulation of dendritic cell antigen processing and presentation	biological process	GO:0002604	11	1	18204	49	CD74
2.922e-02	-3.53	negative regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002924	11	1	18204	49	PTPN6
2.922e-02	-3.53	regulation of cell-cell adhesion mediated by integrin	biological process	GO:0033632	11	1	18204	49	SKAP1
2.922e-02	-3.53	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	49	APOE
2.922e-02	-3.53	pinocytosis	biological process	GO:0006907	11	1	18204	49	DOCK2
2.922e-02	-3.53	regulation of cGMP-mediated signaling	biological process	GO:0010752	11	1	18204	49	PDE11A
2.922e-02	-3.53	regulation of fear response	biological process	GO:1903365	11	1	18204	49	APOE
2.929e-02	-3.53	PTN (pleiotrophin)	protein interactions	5764	106	2	19454	49	NEK6,GSDME
2.935e-02	-3.53	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	45	SYK,CSF1R,NEK6,PRKCD
2.967e-02	-3.52	cellular response to peptide hormone stimulus	biological process	GO:0071375	250	3	18204	49	GAB1,PRKCD,ASS1
2.967e-02	-3.52	D-myo-inositol-5-phosphate metabolism	BIOCYC pathways	META_PWY-6367	9	1	902	3	PLCG2
2.982e-02	-3.51	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	49	APOE
2.982e-02	-3.51	ROPN1L (rhophilin associated tail protein 1 like)	protein interactions	83853	12	1	19454	49	CD74
2.982e-02	-3.51	NCF4 (neutrophil cytosolic factor 4)	protein interactions	4689	12	1	19454	49	PRKCD
2.982e-02	-3.51	SIRPB1 (signal regulatory protein beta 1)	protein interactions	10326	12	1	19454	49	SYK
2.982e-02	-3.51	Cep350 (centrosomal protein 350)	protein interactions	74081	12	1	19454	49	TLN1
2.982e-02	-3.51	SSTR2 (somatostatin receptor 2)	protein interactions	6752	12	1	19454	49	PTPN6
2.982e-02	-3.51	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	49	PTPN6
2.982e-02	-3.51	CDH9 (cadherin 9)	protein interactions	1007	12	1	19454	49	CDH18
2.982e-02	-3.51	FBXO8 (F-box protein 8)	protein interactions	26269	12	1	19454	49	HIF1A
2.982e-02	-3.51	RTL8B (retrotransposon Gag like 8B)	protein interactions	441518	12	1	19454	49	RIN3
2.982e-02	-3.51	ADGRB3 (adhesion G protein-coupled receptor B3)	protein interactions	577	12	1	19454	49	ELMO1
2.982e-02	-3.51	TENM4 (teneurin transmembrane protein 4)	protein interactions	26011	12	1	19454	49	DOCK2
2.982e-02	-3.51	RPL17-C18orf32 (RPL17-C18orf32 readthrough)	protein interactions	100526842	12	1	19454	49	RIN3
2.988e-02	-3.51	DHR-2_Lobe_C	pfam domains	PF20421	11	1	17795	49	DOCK2
2.988e-02	-3.51	DOCK-C2	pfam domains	PF14429	11	1	17795	49	DOCK2
2.988e-02	-3.51	DHR-2_Lobe_A	pfam domains	PF06920	11	1	17795	49	DOCK2
2.988e-02	-3.51	DHR-2_Lobe_B	pfam domains	PF20422	11	1	17795	49	DOCK2
2.992e-02	-3.51	RET (ret proto-oncogene)	protein interactions	5979	268	3	19454	49	NCK1,GAB1,TLN1
3.020e-02	-3.50	PGRMC2 (progesterone receptor membrane component 2)	protein interactions	10424	269	3	19454	49	P2RY6,CD74,RHBDF2
3.027e-02	-3.50	B cell mediated immunity	biological process	GO:0019724	101	2	18204	49	PRKCD,CD74
3.027e-02	-3.50	regulation of carbohydrate biosynthetic process	biological process	GO:0043255	101	2	18204	49	PTAFR,P2RY6
3.027e-02	-3.50	regulation of synapse structure or activity	biological process	GO:0050803	252	3	18204	49	SEMA4A,ARHGAP33,APOE
3.030e-02	-3.50	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	6	16828	45	VAV1,MYO1F,ARHGAP33,ADCY7,BLNK,DENND1B
3.031e-02	-3.50	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	49	EHBP1L1,RIN3
3.031e-02	-3.50	SLC39A14 (solute carrier family 39 member 14)	protein interactions	23516	108	2	19454	49	P2RY2,P2RY6
3.034e-02	-3.50	Succinate Signalling	SMPDB pathways	SMP0083294	6	1	1369	7	HIF1A
3.034e-02	-3.50	Phospholipase C Signaling Pathway	SMPDB pathways	SMP0063783	6	1	1369	7	VAV1
3.035e-02	-3.49	positive regulation of developmental process	biological process	GO:0051094	1385	8	18204	49	VSIR,IL6R,SYK,APOE,HIF1A,SEMA4A,CD74,GAB1
3.074e-02	-3.48	non-membrane spanning protein tyrosine phosphatase activity	molecular function	GO:0004726	12	1	18094	47	PTPN6
3.074e-02	-3.48	vinculin binding	molecular function	GO:0017166	12	1	18094	47	TLN1
3.074e-02	-3.48	MAP-kinase scaffold activity	molecular function	GO:0005078	12	1	18094	47	AKAP13
3.082e-02	-3.48	regulation of interleukin-8 production	biological process	GO:0032677	102	2	18204	49	CD74,SYK
3.096e-02	-3.48	Renal cell carcinoma	KEGG pathways	ko05211	64	2	7161	31	GAB1,HIF1A
3.096e-02	-3.48	Renal cell carcinoma	KEGG pathways	hsa05211	64	2	7161	31	HIF1A,GAB1
3.101e-02	-3.47	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	49	APOE,NCK1,ARHGAP33,PREX1
3.135e-02	-3.46	TIPRL (TOR signaling pathway regulator)	protein interactions	261726	110	2	19454	49	RHBDF2,TLN1
3.135e-02	-3.46	SLC27A2 (solute carrier family 27 member 2)	protein interactions	11001	110	2	19454	49	GSDME,P2RY6
3.141e-02	-3.46	human chr16q23.3	chromosome location	human chr16q23.3	17	1	26134	49	PLCG2
3.141e-02	-3.46	human chr1q31.3	chromosome location	human chr1q31.3	17	1	26134	49	DENND1B
3.163e-02	-3.45	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	12	1	16828	45	CSF1R
3.167e-02	-3.45	DUF3585	smart domains	SM01203	8	1	9717	39	EHBP1L1
3.167e-02	-3.45	VPS9	smart domains	SM00167	8	1	9717	39	RIN3
3.184e-02	-3.45	nuclear membrane disassembly	biological process	GO:0051081	12	1	18204	49	NEK6
3.184e-02	-3.45	regulation of prostaglandin biosynthetic process	biological process	GO:0031392	12	1	18204	49	CD74
3.184e-02	-3.45	serotonin transport	biological process	GO:0006837	12	1	18204	49	SYK
3.184e-02	-3.45	regulation of inflammatory response to wounding	biological process	GO:0106014	12	1	18204	49	PTPN6
3.184e-02	-3.45	nitrogen cycle metabolic process	biological process	GO:0071941	12	1	18204	49	ASS1
3.184e-02	-3.45	mesenchymal cell apoptotic process	biological process	GO:0097152	12	1	18204	49	HIF1A
3.184e-02	-3.45	regulation of chemokine-mediated signaling pathway	biological process	GO:0070099	12	1	18204	49	HIF1A
3.184e-02	-3.45	positive regulation of dendritic cell cytokine production	biological process	GO:0002732	12	1	18204	49	PLCG2
3.184e-02	-3.45	insulin secretion involved in cellular response to glucose stimulus	biological process	GO:0035773	12	1	18204	49	HIF1A
3.184e-02	-3.45	midgut development	biological process	GO:0007494	12	1	18204	49	ASS1
3.184e-02	-3.45	bone trabecula morphogenesis	biological process	GO:0061430	12	1	18204	49	SBNO2
3.184e-02	-3.45	regulation of glomerular mesangial cell proliferation	biological process	GO:0072124	12	1	18204	49	IL6R
3.184e-02	-3.45	cellular response to glucagon stimulus	biological process	GO:0071377	12	1	18204	49	ASS1
3.184e-02	-3.45	regulation of glial cell apoptotic process	biological process	GO:0034350	12	1	18204	49	PRKCD
3.184e-02	-3.45	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	49	APOE
3.184e-02	-3.45	negative regulation of CD4-positive, alpha-beta T cell proliferation	biological process	GO:2000562	12	1	18204	49	VSIR
3.184e-02	-3.45	response to macrophage colony-stimulating factor	biological process	GO:0036005	12	1	18204	49	CSF1R
3.184e-02	-3.45	urea metabolic process	biological process	GO:0019627	12	1	18204	49	ASS1
3.188e-02	-3.45	KIAA2013 (KIAA2013)	protein interactions	90231	111	2	19454	49	P2RY2,PTAFR
3.193e-02	-3.44	MAPK1 (ERK2) activation	REACTOME pathways	R-HSA-112411	9	1	10285	37	IL6R
3.193e-02	-3.44	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	REACTOME pathways	R-HSA-8849469	9	1	10285	37	ARAP1
3.194e-02	-3.44	regulation of dephosphorylation	biological process	GO:0035303	104	2	18204	49	NCK1,PRKCD
3.194e-02	-3.44	regulation of actomyosin structure organization	biological process	GO:0110020	104	2	18204	49	ARAP1,AKAP13
3.195e-02	-3.44	Signaling by SCF-KIT	REACTOME pathways	R-HSA-1433557	337	4	10285	37	VAV1,TLN1,PTPN6,GAB1
3.202e-02	-3.44	Rhomboid-like	gene3d domains	1.20.1540.10	10	1	14470	47	RHBDF2
3.202e-02	-3.44	VPS9 domain	gene3d domains	1.20.1050.80	10	1	14470	47	RIN3
3.204e-02	-3.44	IRF_1	prosite domains	PS00601	9	1	12186	44	IRF5
3.204e-02	-3.44	IRF_2	prosite domains	PS51507	9	1	12186	44	IRF5
3.204e-02	-3.44	BEACH	prosite domains	PS50197	9	1	12186	44	WDFY4
3.206e-02	-3.44	extraskeletal	COSMIC cancer mutations	extraskeletal	903	6	16828	45	BLNK,ARHGAP33,ADCY7,VAV1,MYO1F,DENND1B
3.214e-02	-3.44	small GTPase-mediated signal transduction	biological process	GO:0007264	258	3	18204	49	ARHGAP33,ELMO1,DOCK2
3.224e-02	-3.43	HMOX2 (heme oxygenase 2)	protein interactions	3163	276	3	19454	49	P2RY6,CD74,APOE
3.226e-02	-3.43	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	49	APOE
3.226e-02	-3.43	EEIG1 (estrogen-induced osteoclastogenesis regulator 1)	protein interactions	399665	13	1	19454	49	SKAP1
3.226e-02	-3.43	RINL (Ras and Rab interactor like)	protein interactions	126432	13	1	19454	49	RIN3
3.226e-02	-3.43	MYBPC3 (myosin binding protein C3)	protein interactions	4607	13	1	19454	49	BLNK
3.226e-02	-3.43	SEMA4A (semaphorin 4A)	protein interactions	64218	13	1	19454	49	SEMA4A
3.226e-02	-3.43	GABPB2 (GA binding protein transcription factor subunit beta 2)	protein interactions	126626	13	1	19454	49	PLCG2
3.226e-02	-3.43	NFAM1 (NFAT activating protein with ITAM motif 1)	protein interactions	150372	13	1	19454	49	SYK
3.226e-02	-3.43	IL6 (interleukin 6)	protein interactions	3569	13	1	19454	49	IL6R
3.226e-02	-3.43	RTL10 (retrotransposon Gag like 10)	protein interactions	79680	13	1	19454	49	PLCG2
3.226e-02	-3.43	KCNQ4 (potassium voltage-gated channel subfamily Q member 4)	protein interactions	9132	13	1	19454	49	CSF1R
3.227e-02	-3.43	INTFRNREGFCT	prints domains	PR00267	9	1	5227	19	IRF5
3.241e-02	-3.43	CAV2 (caveolin 2)	protein interactions	858	112	2	19454	49	NCK1,P2RY2
3.241e-02	-3.43	UBE2V1 (ubiquitin conjugating enzyme E2 V1)	protein interactions	7335	112	2	19454	49	P2RY6,RHBDF2
3.241e-02	-3.43	HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)	protein interactions	3157	112	2	19454	49	RIN3,TLN1
3.251e-02	-3.43	positive regulation of myeloid cell differentiation	biological process	GO:0045639	105	2	18204	49	CD74,HIF1A
3.251e-02	-3.43	biomineral tissue development	biological process	GO:0031214	105	2	18204	49	HIF1A,SBNO2
3.251e-02	-3.43	cellular response to alcohol	biological process	GO:0097306	105	2	18204	49	ADCY7,P2RY6
3.251e-02	-3.43	response to type II interferon	biological process	GO:0034341	105	2	18204	49	CD74,ASS1
3.251e-02	-3.43	antigen processing and presentation	biological process	GO:0019882	105	2	18204	49	CD74,WDFY4
3.251e-02	-3.43	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	49	ARHGAP33,APOE
3.256e-02	-3.42	dDENN	pfam domains	PF03455	12	1	17795	49	DENND1B
3.284e-02	-3.42	early phagosome	cellular component	GO:0032009	13	1	19108	49	SYK
3.284e-02	-3.42	chylomicron	cellular component	GO:0042627	13	1	19108	49	APOE
3.294e-02	-3.41	ARHGEF7 (Rho guanine nucleotide exchange factor 7)	protein interactions	8874	113	2	19454	49	NCK1,GIT2
3.307e-02	-3.41	cellular response to ketone	biological process	GO:1901655	106	2	18204	49	ASS1,P2RY6
3.309e-02	-3.41	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	45	SYK,CSF1R,PRKCD,NEK6
3.326e-02	-3.40	insulin receptor substrate binding	molecular function	GO:0043560	13	1	18094	47	PRKCD
3.347e-02	-3.40	ATP5MF (ATP synthase membrane subunit f)	protein interactions	9551	114	2	19454	49	P2RY6,VAV1
3.349e-02	-3.40	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	9	18204	49	PTAFR,CSF1R,PRKCD,PIK3R5,ADCY7,SYK,PLCG2,PTPN6,NEK6
3.355e-02	-3.39	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	45	SYK,CSF1R,PRKCD,NEK6
3.372e-02	-3.39	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	265	3	16828	45	SYK,PLCG2,BLNK
3.399e-02	-3.38	adenoma	COSMIC cancer mutations	adenoma	2873	13	16828	45	TLN1,PRKCD,HIF1A,WDFY4,SKAP1,PDE11A,CDH18,IPCEF1,DOCK2,PLCG2,SYK,APOE,PREX1
3.430e-02	-3.37	Kit receptor signaling pathway	WikiPathways	WP304	60	2	5310	26	PTPN6,VAV1
3.439e-02	-3.37	regulation of protein secretion	biological process	GO:0050708	265	3	18204	49	RHBDF2,HIF1A,APOE
3.443e-02	-3.37	positive regulation of cell development	biological process	GO:0010720	458	4	18204	49	VSIR,SYK,CD74,HIF1A
3.444e-02	-3.37	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	biological process	GO:1903377	13	1	18204	49	HIF1A
3.444e-02	-3.37	positive regulation of nitric-oxide synthase activity	biological process	GO:0051000	13	1	18204	49	HIF1A
3.444e-02	-3.37	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	49	IL6R
3.444e-02	-3.37	membrane disassembly	biological process	GO:0030397	13	1	18204	49	NEK6
3.444e-02	-3.37	regulation of thymocyte apoptotic process	biological process	GO:0070243	13	1	18204	49	HIF1A
3.444e-02	-3.37	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	1	18204	49	APOE
3.444e-02	-3.37	positive regulation of leukocyte tethering or rolling	biological process	GO:1903238	13	1	18204	49	PTAFR
3.444e-02	-3.37	phospholipid efflux	biological process	GO:0033700	13	1	18204	49	APOE
3.444e-02	-3.37	regulation of T-helper 2 cell cytokine production	biological process	GO:2000551	13	1	18204	49	DENND1B
3.444e-02	-3.37	positive regulation of mitophagy	biological process	GO:1901526	13	1	18204	49	HIF1A
3.444e-02	-3.37	response to peptidoglycan	biological process	GO:0032494	13	1	18204	49	IRF5
3.444e-02	-3.37	regulation of sphingolipid biosynthetic process	biological process	GO:0090153	13	1	18204	49	PRKCD
3.444e-02	-3.37	modulation of process of another organism	biological process	GO:0035821	13	1	18204	49	SYK
3.444e-02	-3.37	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	49	APOE
3.444e-02	-3.37	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	49	PRKCD
3.444e-02	-3.37	positive regulation of phagocytosis, engulfment	biological process	GO:0060100	13	1	18204	49	PLCG2
3.444e-02	-3.37	positive regulation of membrane invagination	biological process	GO:1905155	13	1	18204	49	PLCG2
3.444e-02	-3.37	regulation of ceramide biosynthetic process	biological process	GO:2000303	13	1	18204	49	PRKCD
3.470e-02	-3.36	WIPF3 (WAS/WASL interacting protein family member 3)	protein interactions	644150	14	1	19454	49	NCK1
3.470e-02	-3.36	AZIN2 (antizyme inhibitor 2)	protein interactions	113451	14	1	19454	49	TLN1
3.470e-02	-3.36	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	49	P2RY6
3.470e-02	-3.36	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	49	PRKCD
3.470e-02	-3.36	CSF3 (colony stimulating factor 3)	protein interactions	1440	14	1	19454	49	PARVG
3.470e-02	-3.36	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	49	APOE
3.470e-02	-3.36	C9 (complement C9)	protein interactions	735	14	1	19454	49	APOE
3.470e-02	-3.36	RHBDF1 (rhomboid 5 homolog 1)	protein interactions	64285	14	1	19454	49	HIF1A
3.470e-02	-3.36	Fez2 (fasciculation and elongation protein zeta 2)	protein interactions	225020	14	1	19454	49	DENND1B
3.481e-02	-3.36	reactive oxygen species metabolic process	biological process	GO:0072593	109	2	18204	49	VAV1,PREX1
3.490e-02	-3.36	negative regulation of transport	biological process	GO:0051051	460	4	18204	49	RHBDF2,RIN3,CD74,APOE
3.494e-02	-3.35	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	45	PRKCD,NEK6,CSF1R,SYK
3.496e-02	-3.35	IPO7 (importin 7)	protein interactions	10527	285	3	19454	49	RIN3,RHBDF2,P2RY6
3.504e-02	-3.35	human chr15q25.3	chromosome location	human chr15q25.3	19	1	26134	49	AKAP13
3.504e-02	-3.35	regulation of protein serine/threonine kinase activity	biological process	GO:0071900	267	3	18204	49	PIK3R5,PRKCD,APOE
3.517e-02	-3.35	-	gene3d domains	1.25.40.410	11	1	14470	47	DOCK2
3.517e-02	-3.35	-	gene3d domains	1.20.58.740	11	1	14470	47	DOCK2
3.527e-02	-3.34	LDHB (lactate dehydrogenase B)	protein interactions	3945	286	3	19454	49	RIN3,VAV1,ASS1
3.537e-02	-3.34	protein localization to membrane	biological process	GO:0072657	462	4	18204	49	FYB1,SKAP1,APOE,RHBDF2
3.538e-02	-3.34	transcription coregulator binding	molecular function	GO:0001221	114	2	18094	47	HIF1A,NEK6
3.541e-02	-3.34	MET receptor recycling	REACTOME pathways	R-HSA-8875656	10	1	10285	37	GAB1
3.541e-02	-3.34	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	37	ADCY7
3.541e-02	-3.34	MAPK3 (ERK1) activation	REACTOME pathways	R-HSA-110056	10	1	10285	37	IL6R
3.541e-02	-3.34	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	37	GAB1
3.541e-02	-3.34	Urea cycle	REACTOME pathways	R-HSA-70635	10	1	10285	37	ASS1
3.554e-02	-3.34	VPS9	prosite domains	PS51205	10	1	12186	44	RIN3
3.556e-02	-3.34	Beach	smart domains	SM01026	9	1	9717	39	WDFY4
3.556e-02	-3.34	IRF	smart domains	SM00348	9	1	9717	39	IRF5
3.558e-02	-3.34	PSMD13 (proteasome 26S subunit, non-ATPase 13)	protein interactions	5719	287	3	19454	49	PREX1,PTPN6,P2RY6
3.565e-02	-3.33	NCKIPSD (NCK interacting protein with SH3 domain)	protein interactions	51517	118	2	19454	49	NCK1,GIT2
3.577e-02	-3.33	Toll-like receptor binding	molecular function	GO:0035325	14	1	18094	47	SYK
3.577e-02	-3.33	oxygen carrier activity	molecular function	GO:0005344	14	1	18094	47	IPCEF1
3.585e-02	-3.33	cellular response to organic cyclic compound	biological process	GO:0071407	464	4	18204	49	P2RY2,PTAFR,P2RY6,ASS1
3.598e-02	-3.32	positive regulation of lipid localization	biological process	GO:1905954	111	2	18204	49	PRKCD,APOE
3.604e-02	-3.32	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051896	270	3	18204	49	CSF1R,PTPN6,PIK3R5
3.618e-02	-3.32	superpathway of L-citrulline metabolism	BIOCYC pathways	META_PWY-5004	11	1	902	3	ASS1
3.620e-02	-3.32	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	49	APOE,CD74
3.620e-02	-3.32	UXT (ubiquitously expressed prefoldin like chaperone)	protein interactions	8409	119	2	19454	49	SKAP1,NCK1
3.638e-02	-3.31	carboxylic acid biosynthetic process	biological process	GO:0046394	271	3	18204	49	ASS1,CD74,SYK
3.642e-02	-3.31	Rhomboid-like_sf	interpro domains	IPR035952	14	1	18521	49	RHBDF2
3.643e-02	-3.31	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection	WikiPathways	WP3863	62	2	5310	26	NCK1,PTPN6
3.647e-02	-3.31	phosphorus metabolic process	biological process	GO:0006793	1707	9	18204	49	PTPN6,PLCG2,NEK6,PTAFR,CSF1R,PIK3R5,PRKCD,SYK,ADCY7
3.648e-02	-3.31	protein-containing complex binding	molecular function	GO:0044877	1772	9	18094	47	MYO1F,SBNO2,TLN1,SYK,APOE,DOCK2,CD74,FYB1,PIK3R5
3.676e-02	-3.30	CD79B (CD79b molecule)	protein interactions	974	120	2	19454	49	SYK,PTPN6
3.676e-02	-3.30	ELP3 (elongator acetyltransferase complex subunit 3)	protein interactions	55140	120	2	19454	49	HIF1A,SKAP1
3.704e-02	-3.30	TUBA4A (tubulin alpha 4a)	protein interactions	7277	501	4	19454	49	VAV1,RIN3,SYK,RHBDF2
3.704e-02	-3.30	regulation of mesenchymal cell apoptotic process	biological process	GO:2001053	14	1	18204	49	HIF1A
3.704e-02	-3.30	positive regulation of heterotypic cell-cell adhesion	biological process	GO:0034116	14	1	18204	49	SKAP1
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	P2RY6
3.704e-02	-3.30	T-helper 1 cell differentiation	biological process	GO:0045063	14	1	18204	49	SEMA4A
3.704e-02	-3.30	T-helper cell lineage commitment	biological process	GO:0002295	14	1	18204	49	IL6R
3.704e-02	-3.30	cellular response to ethanol	biological process	GO:0071361	14	1	18204	49	ADCY7
3.704e-02	-3.30	cellular response to lithium ion	biological process	GO:0071285	14	1	18204	49	ADCY7
3.704e-02	-3.30	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	49	APOE
3.704e-02	-3.30	regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001279	14	1	18204	49	CD74
3.704e-02	-3.30	alpha-beta T cell proliferation	biological process	GO:0046633	14	1	18204	49	DOCK2
3.704e-02	-3.30	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	49	APOE
3.704e-02	-3.30	positive regulation of receptor recycling	biological process	GO:0001921	14	1	18204	49	ARAP1
3.704e-02	-3.30	positive regulation of viral entry into host cell	biological process	GO:0046598	14	1	18204	49	CD74
3.704e-02	-3.30	positive regulation by symbiont of entry into host	biological process	GO:0075294	14	1	18204	49	CD74
3.704e-02	-3.30	inflammatory response to wounding	biological process	GO:0090594	14	1	18204	49	HIF1A
3.704e-02	-3.30	immunological synapse formation	biological process	GO:0001771	14	1	18204	49	DOCK2
3.704e-02	-3.30	positive regulation of phospholipid metabolic process	biological process	GO:1903727	14	1	18204	49	PRKCD
3.704e-02	-3.30	interleukin-6-mediated signaling pathway	biological process	GO:0070102	14	1	18204	49	IL6R
3.714e-02	-3.29	IRAK1BP1 (interleukin 1 receptor associated kinase 1 binding protein 1)	protein interactions	134728	15	1	19454	49	RIN3
3.714e-02	-3.29	AANAT (aralkylamine N-acetyltransferase)	protein interactions	15	15	1	19454	49	P2RY6
3.714e-02	-3.29	MEP1B (meprin A subunit beta)	protein interactions	4225	15	1	19454	49	PRKCD
3.714e-02	-3.29	ADRA2A (adrenoceptor alpha 2A)	protein interactions	150	15	1	19454	49	PRKCD
3.714e-02	-3.29	NBEAL1 (neurobeachin like 1)	protein interactions	65065	15	1	19454	49	HIF1A
3.714e-02	-3.29	GCK (glucokinase)	protein interactions	2645	15	1	19454	49	GMIP
3.714e-02	-3.29	EBI3 (Epstein-Barr virus induced 3)	protein interactions	10148	15	1	19454	49	PRKCD
3.714e-02	-3.29	IRF6 (interferon regulatory factor 6)	protein interactions	3664	15	1	19454	49	IRF5
3.717e-02	-3.29	regulation of regulated secretory pathway	biological process	GO:1903305	113	2	18204	49	PTAFR,SYK
3.717e-02	-3.29	negative regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001243	113	2	18204	49	HIF1A,CD74
3.729e-02	-3.29	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	2	10285	37	PRKCD,ADCY7
3.732e-02	-3.29	CDSN (corneodesmosin)	protein interactions	1041	121	2	19454	49	PARVG,VAV1
3.732e-02	-3.29	MED15 (mediator complex subunit 15)	protein interactions	51586	121	2	19454	49	RIN3,HIF1A
3.732e-02	-3.29	EIF3J (eukaryotic translation initiation factor 3 subunit J)	protein interactions	8669	121	2	19454	49	CD74,P2RY6
3.732e-02	-3.29	POLR3B (RNA polymerase III subunit B)	protein interactions	55703	121	2	19454	49	SKAP1,CD74
3.740e-02	-3.29	organic acid biosynthetic process	biological process	GO:0016053	274	3	18204	49	ASS1,SYK,CD74
3.747e-02	-3.28	NUDC (nuclear distribution C, dynein complex regulator)	protein interactions	10726	293	3	19454	49	P2RY6,TLN1,RIN3
3.776e-02	-3.28	Prot_kinase_dom	interpro domains	IPR000719	480	4	18521	49	CSF1R,NEK6,SYK,PRKCD
3.777e-02	-3.28	regulation of cell killing	biological process	GO:0031341	114	2	18204	49	VAV1,SYK
3.777e-02	-3.28	icosanoid metabolic process	biological process	GO:0006690	114	2	18204	49	CD74,SYK
3.780e-02	-3.28	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	49	APOE
3.784e-02	-3.27	parathyroid	COSMIC cancer mutations	parathyroid	476	4	16828	45	PLCG2,PRKCD,PDE11A,DOCK2
3.788e-02	-3.27	ELK1 (ETS transcription factor ELK1)	protein interactions	2002	122	2	19454	49	PLCG2,HIF1A
3.796e-02	-3.27	DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	3301	505	4	19454	49	HIF1A,P2RY6,RIN3,VAV1
3.796e-02	-3.27	ATP5F1A (ATP synthase F1 subunit alpha)	protein interactions	498	505	4	19454	49	P2RY6,APOE,RIN3,VAV1
3.819e-02	-3.27	circulatory system development	biological process	GO:0072359	933	6	18204	49	GAB1,APOE,SYK,AKAP13,SEMA4A,HIF1A
3.828e-02	-3.26	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	47	GSDME
3.828e-02	-3.26	1-phosphatidylinositol-3-kinase regulator activity	molecular function	GO:0046935	15	1	18094	47	PIK3R5
3.830e-02	-3.26	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	47	TLN1
3.844e-02	-3.26	NAMPT (nicotinamide phosphoribosyltransferase)	protein interactions	10135	123	2	19454	49	P2RY6,ASS1
3.852e-02	-3.26	Axon guidance	KEGG pathways	hsa04360	174	3	7161	31	NCK1,SEMA4A,PLCG2
3.852e-02	-3.26	Axon guidance	KEGG pathways	ko04360	174	3	7161	31	NCK1,PLCG2,SEMA4A
3.867e-02	-3.25	Alpha-synuclein signaling	Pathway Interaction DB	alphasynuclein_pathway	32	2	2226	22	PRKCD,SYK
3.867e-02	-3.25	Trk receptor signaling mediated by PI3K and PLC-gamma	Pathway Interaction DB	pi3kplctrkpathway	32	2	2226	22	GAB1,PRKCD
3.883e-02	-3.25	trunk	COSMIC cancer mutations	trunk	3554	15	16828	45	GIT2,RIN3,EHBP1L1,VAV1,SYK,BLNK,WDFY4,SKAP1,PDE11A,TLN1,GMIP,ARHGAP15,MYO1F,ARHGAP27,DOCK2
3.889e-02	-3.25	MET activates RAP1 and RAC1	REACTOME pathways	R-HSA-8875555	11	1	10285	37	GAB1
3.889e-02	-3.25	Interleukin-6 signaling	REACTOME pathways	R-HSA-1059683	11	1	10285	37	IL6R
3.889e-02	-3.25	Signaling by FGFR4 in disease	REACTOME pathways	R-HSA-5655291	11	1	10285	37	GAB1
3.891e-02	-3.25	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	37	VAV1,GAB1
3.897e-02	-3.24	PI-PLC_fam	interpro domains	IPR001192	15	1	18521	49	PLCG2
3.897e-02	-3.24	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	1	18521	49	PLCG2
3.897e-02	-3.24	SMAD-like_dom_sf	interpro domains	IPR017855	15	1	18521	49	IRF5
3.898e-02	-3.24	regulation of alpha-beta T cell activation	biological process	GO:0046634	116	2	18204	49	SYK,VSIR
3.901e-02	-3.24	TM9SF3 (transmembrane 9 superfamily member 3)	protein interactions	56889	124	2	19454	49	P2RY6,P2RY2
3.901e-02	-3.24	RNF5 (ring finger protein 5)	protein interactions	6048	124	2	19454	49	HIF1A,P2RY2
3.901e-02	-3.24	TNK2 (tyrosine kinase non receptor 2)	protein interactions	10188	124	2	19454	49	NEK6,NCK1
3.901e-02	-3.24	ERLEC1 (endoplasmic reticulum lectin 1)	protein interactions	27248	124	2	19454	49	SEMA4A,P2RY6
3.902e-02	-3.24	DOCKER	prosite domains	PS51651	11	1	12186	44	DOCK2
3.902e-02	-3.24	C2_DOCK	prosite domains	PS51650	11	1	12186	44	DOCK2
3.909e-02	-3.24	ALDH3A2 (aldehyde dehydrogenase 3 family member A2)	protein interactions	224	298	3	19454	49	RHBDF2,RIN3,P2RY6
3.909e-02	-3.24	UBR4 (ubiquitin protein ligase E3 component n-recognin 4)	protein interactions	23352	298	3	19454	49	CD74,NCK1,P2RY6
3.930e-02	-3.24	SM22CALPONIN	prints domains	PR00888	11	1	5227	19	VAV1
3.956e-02	-3.23	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	49	CDH18
3.956e-02	-3.23	RASGRP3 (RAS guanyl releasing protein 3)	protein interactions	25780	16	1	19454	49	PRKCD
3.956e-02	-3.23	TNFRSF25 (TNF receptor superfamily member 25)	protein interactions	8718	16	1	19454	49	PTPN6
3.956e-02	-3.23	KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)	protein interactions	3761	16	1	19454	49	PRKCD
3.956e-02	-3.23	PRICKLE4 (prickle planar cell polarity protein 4)	protein interactions	29964	16	1	19454	49	NEK6
3.956e-02	-3.23	NEUROG1 (neurogenin 1)	protein interactions	4762	16	1	19454	49	ASS1
3.956e-02	-3.23	EPO (erythropoietin)	protein interactions	2056	16	1	19454	49	HIF1A
3.956e-02	-3.23	SELPLG (selectin P ligand)	protein interactions	6404	16	1	19454	49	SYK
3.956e-02	-3.23	IL1RL2 (interleukin 1 receptor like 2)	protein interactions	8808	16	1	19454	49	MYO1F
3.956e-02	-3.23	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	49	PLCG2
3.956e-02	-3.23	TAMALIN (trafficking regulator and scaffold protein tamalin)	protein interactions	160622	16	1	19454	49	SYK
3.957e-02	-3.23	organic hydroxy compound metabolic process	biological process	GO:1901615	479	4	18204	49	APOE,HIF1A,PTAFR,PLCG2
3.958e-02	-3.23	SCAMP2 (secretory carrier membrane protein 2)	protein interactions	10066	125	2	19454	49	PTAFR,P2RY2
3.959e-02	-3.23	cellular detoxification	biological process	GO:1990748	117	2	18204	49	IPCEF1,APOE
3.964e-02	-3.23	negative regulation of immunoglobulin mediated immune response	biological process	GO:0002890	15	1	18204	49	PTPN6
3.964e-02	-3.23	positive regulation of granulocyte macrophage colony-stimulating factor production	biological process	GO:0032725	15	1	18204	49	SYK
3.964e-02	-3.23	negative regulation of DNA damage response, signal transduction by p53 class mediator	biological process	GO:0043518	15	1	18204	49	CD74
3.964e-02	-3.23	neutrophil activation involved in immune response	biological process	GO:0002283	15	1	18204	49	SYK
3.964e-02	-3.23	regulation of phagocytosis, engulfment	biological process	GO:0060099	15	1	18204	49	PLCG2
3.964e-02	-3.23	negative regulation of B cell apoptotic process	biological process	GO:0002903	15	1	18204	49	CD74
3.964e-02	-3.23	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902166	15	1	18204	49	CD74
3.964e-02	-3.23	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	49	APOE
3.964e-02	-3.23	negative regulation of B cell mediated immunity	biological process	GO:0002713	15	1	18204	49	PTPN6
3.964e-02	-3.23	regulation of membrane invagination	biological process	GO:1905153	15	1	18204	49	PLCG2
3.964e-02	-3.23	response to laminar fluid shear stress	biological process	GO:0034616	15	1	18204	49	ASS1
3.964e-02	-3.23	oxygen transport	biological process	GO:0015671	15	1	18204	49	IPCEF1
3.964e-02	-3.23	parturition	biological process	GO:0007567	15	1	18204	49	PTAFR
3.964e-02	-3.23	columnar/cuboidal epithelial cell maturation	biological process	GO:0002069	15	1	18204	49	HIF1A
3.964e-02	-3.23	positive regulation of monocyte chemotactic protein-1 production	biological process	GO:0071639	15	1	18204	49	SYK
3.964e-02	-3.23	positive regulation of hormone metabolic process	biological process	GO:0032352	15	1	18204	49	HIF1A
3.964e-02	-3.23	arginine metabolic process	biological process	GO:0006525	15	1	18204	49	ASS1
3.964e-02	-3.23	collagen-activated signaling pathway	biological process	GO:0038065	15	1	18204	49	SYK
3.964e-02	-3.23	negative regulation of endoplasmic reticulum unfolded protein response	biological process	GO:1900102	15	1	18204	49	NCK1
3.964e-02	-3.23	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	49	APOE
4.008e-02	-3.22	ARRB1 (arrestin beta 1)	protein interactions	408	301	3	19454	49	HIF1A,NEK6,PTAFR
4.016e-02	-3.21	KCTD17 (potassium channel tetramerization domain containing 17)	protein interactions	79734	126	2	19454	49	RIN3,PLCG2
4.016e-02	-3.21	DAG1 (dystroglycan 1)	protein interactions	1605	126	2	19454	49	TLN1,NCK1
4.020e-02	-3.21	biological process involved in interaction with symbiont	biological process	GO:0051702	118	2	18204	49	CSF1R,APOE
4.046e-02	-3.21	human chr2q31.2	chromosome location	human chr2q31.2	22	1	26134	49	PDE11A
4.053e-02	-3.21	PI-PLC-Y	pfam domains	PF00387	15	1	17795	49	PLCG2
4.055e-02	-3.21	RAB GEFs exchange GTP for GDP on RABs	REACTOME pathways	R-HSA-8876198	89	2	10285	37	RIN3,DENND1B
4.061e-02	-3.20	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	4	16828	45	CSF1R,NEK6,PRKCD,SYK
4.065e-02	-3.20	membrane protein complex	cellular component	GO:0098796	1261	7	19108	49	SKAP1,PIK3R5,CD74,PTPN6,CDH18,SYK,IL6R
4.072e-02	-3.20	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	3	5310	26	PRKCD,ADCY7,PLCG2
4.074e-02	-3.20	TUBA3C (tubulin alpha 3c)	protein interactions	7278	127	2	19454	49	VAV1,PLCG2
4.074e-02	-3.20	ASPH (aspartate beta-hydroxylase)	protein interactions	444	303	3	19454	49	VAV1,RHBDF2,P2RY6
4.074e-02	-3.20	PPIB (peptidylprolyl isomerase B)	protein interactions	5479	303	3	19454	49	PREX1,VAV1,IRF5
4.074e-02	-3.20	EBNA1BP2 (EBNA1 binding protein 2)	protein interactions	10969	303	3	19454	49	SYK,PTPN6,GMIP
4.076e-02	-3.20	TyrKc	smart domains	SM00219	80	2	9717	39	CSF1R,SYK
4.078e-02	-3.20	diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004697	16	1	18094	47	PRKCD
4.078e-02	-3.20	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	47	ADCY7
4.078e-02	-3.20	cGMP binding	molecular function	GO:0030553	16	1	18094	47	PDE11A
4.082e-02	-3.20	negative regulation of protein transport	biological process	GO:0051224	119	2	18204	49	RHBDF2,APOE
4.083e-02	-3.20	Oncostatin M Signaling Pathway	WikiPathways	WP2374	66	2	5310	26	HIF1A,PRKCD
4.083e-02	-3.20	AGE/RAGE pathway	WikiPathways	WP2324	66	2	5310	26	HIF1A,PRKCD
4.131e-02	-3.19	transmembrane signaling receptor activity	molecular function	GO:0004888	1251	7	18094	47	PTAFR,P2RY6,PTPN6,IL6R,P2RY2,CD74,CSF1R
4.132e-02	-3.19	EIF2B2 (eukaryotic translation initiation factor 2B subunit beta)	protein interactions	8892	128	2	19454	49	PTAFR,NCK1
4.138e-02	-3.19	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	37	GAB1,VAV1
4.140e-02	-3.18	7tm_1	pfam domains	PF00001	279	3	17795	49	P2RY2,PTAFR,P2RY6
4.143e-02	-3.18	-	gene3d domains	3.30.450.200	13	1	14470	47	DENND1B
4.152e-02	-3.18	uDENN_dom	interpro domains	IPR005113	16	1	18521	49	DENND1B
4.152e-02	-3.18	DENN_C	interpro domains	IPR043153	16	1	18521	49	DENND1B
4.152e-02	-3.18	dDENN_dom	interpro domains	IPR005112	16	1	18521	49	DENND1B
4.155e-02	-3.18	DNAJA2 (DnaJ heat shock protein family (Hsp40) member A2)	protein interactions	10294	520	4	19454	49	HIF1A,P2RY6,RIN3,VAV1
4.190e-02	-3.17	PLD1 (phospholipase D1)	protein interactions	5337	129	2	19454	49	PLCG2,HIF1A
4.190e-02	-3.17	non_seminoma	COSMIC cancer mutations	non_seminoma	492	4	16828	45	SYK,NEK6,PRKCD,CSF1R
4.196e-02	-3.17	normal	COSMIC cancer mutations	normal	16	1	16828	45	CSF1R
4.198e-02	-3.17	ARL4A (ADP ribosylation factor like GTPase 4A)	protein interactions	10124	17	1	19454	49	ELMO1
4.198e-02	-3.17	SAT2 (spermidine/spermine N1-acetyltransferase family member 2)	protein interactions	112483	17	1	19454	49	HIF1A
4.198e-02	-3.17	SLAMF6 (SLAM family member 6)	protein interactions	114836	17	1	19454	49	PTPN6
4.198e-02	-3.17	PLB1 (phospholipase B1)	protein interactions	151056	17	1	19454	49	RIN3
4.198e-02	-3.17	CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2)	protein interactions	10370	17	1	19454	49	HIF1A
4.198e-02	-3.17	RAD54L (RAD54 like)	protein interactions	8438	17	1	19454	49	NCK1
4.198e-02	-3.17	FAM131C (family with sequence similarity 131 member C)	protein interactions	348487	17	1	19454	49	RHBDF2
4.198e-02	-3.17	RIMBP3C (RIMS binding protein 3C)	protein interactions	150221	17	1	19454	49	NEK6
4.198e-02	-3.17	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	49	APOE
4.207e-02	-3.17	centriolar satellite	cellular component	GO:0034451	127	2	19108	49	PIK3R5,NEK6
4.216e-02	-3.17	skin-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma	493	4	16828	45	SYK,ARHGAP33,CSF1R,HIF1A
4.221e-02	-3.17	Platelet homeostasis	REACTOME pathways	R-HSA-418346	91	2	10285	37	PTPN6,PDE11A
4.223e-02	-3.16	regulation of cell proliferation involved in kidney development	biological process	GO:1901722	16	1	18204	49	IL6R
4.223e-02	-3.16	response to lithium ion	biological process	GO:0010226	16	1	18204	49	ADCY7
4.223e-02	-3.16	glutamine family amino acid biosynthetic process	biological process	GO:0009084	16	1	18204	49	ASS1
4.223e-02	-3.16	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	49	APOE
4.223e-02	-3.16	positive regulation of response to tumor cell	biological process	GO:0002836	16	1	18204	49	GSDME
4.223e-02	-3.16	tricarboxylic acid metabolic process	biological process	GO:0072350	16	1	18204	49	ASS1
4.223e-02	-3.16	intestinal epithelial cell development	biological process	GO:0060576	16	1	18204	49	HIF1A
4.223e-02	-3.16	negative regulation of alpha-beta T cell proliferation	biological process	GO:0046642	16	1	18204	49	VSIR
4.223e-02	-3.16	response to ether	biological process	GO:0045472	16	1	18204	49	PTAFR
4.223e-02	-3.16	cellular response to prostaglandin E stimulus	biological process	GO:0071380	16	1	18204	49	P2RY6
4.223e-02	-3.16	lactate metabolic process	biological process	GO:0006089	16	1	18204	49	HIF1A
4.223e-02	-3.16	positive regulation of B cell differentiation	biological process	GO:0045579	16	1	18204	49	SYK
4.223e-02	-3.16	positive regulation of autophagy of mitochondrion	biological process	GO:1903599	16	1	18204	49	HIF1A
4.223e-02	-3.16	positive regulation of immune response to tumor cell	biological process	GO:0002839	16	1	18204	49	GSDME
4.223e-02	-3.16	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	49	APOE
4.223e-02	-3.16	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	49	APOE
4.226e-02	-3.16	human chr3q22.3	chromosome location	human chr3q22.3	23	1	26134	49	NCK1
4.234e-02	-3.16	positive regulation of innate immune response	biological process	GO:0045089	288	3	18204	49	PLCG2,VAV1,SYK
4.235e-02	-3.16	CD28 dependent Vav1 pathway	REACTOME pathways	R-HSA-389359	12	1	10285	37	VAV1
4.235e-02	-3.16	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	37	HIF1A
4.235e-02	-3.16	PECAM1 interactions	REACTOME pathways	R-HSA-210990	12	1	10285	37	PTPN6
4.239e-02	-3.16	Bacterial invasion of epithelial cells	KEGG pathways	hsa05100	76	2	7161	31	GAB1,ELMO1
4.239e-02	-3.16	Bacterial invasion of epithelial cells	KEGG pathways	ko05100	76	2	7161	31	GAB1,ELMO1
4.243e-02	-3.16	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	23	16828	45	PARVG,CDH18,ELMO1,PIK3R5,ARHGAP33,PREX1,MYO1F,ARHGAP27,ASS1,SKAP1,WDFY4,ADCY7,PRKCD,P2RY6,SYK,DOCK2,ARAP1,PDE11A,NCK1,VAV1,AKAP13,RIN3,PLCG2
4.249e-02	-3.16	YIPF5 (Yip1 domain family member 5)	protein interactions	81555	130	2	19454	49	P2RY2,P2RY6
4.252e-02	-3.16	Calcium signaling pathway	KEGG pathways	ko04020	181	3	7161	31	ADCY7,PTAFR,PLCG2
4.252e-02	-3.16	Calcium signaling pathway	KEGG pathways	hsa04020	181	3	7161	31	PTAFR,ADCY7,PLCG2
4.266e-02	-3.15	D-myo-inositol (1,4,5)-trisphosphate biosynthesis	BIOCYC pathways	META_PWY-6351	13	1	902	3	PLCG2
4.269e-02	-3.15	Insulin Signaling	WikiPathways	WP481	161	3	5310	26	PRKCD,ARHGAP33,GAB1
4.273e-02	-3.15	MHC class II protein complex	cellular component	GO:0042613	17	1	19108	49	CD74
4.299e-02	-3.15	leg	COSMIC cancer mutations	leg	969	6	16828	45	VAV1,CDH18,SKAP1,PIK3R5,AKAP13,CSF1R
4.308e-02	-3.14	TBCD (tubulin folding cofactor D)	protein interactions	6904	131	2	19454	49	HIF1A,RIN3
4.318e-02	-3.14	uDENN	pfam domains	PF03456	16	1	17795	49	DENND1B
4.323e-02	-3.14	Arf6 signaling events	Pathway Interaction DB	arf6_pathway	34	2	2226	22	IPCEF1,NCK1
4.325e-02	-3.14	miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma	WikiPathways	WP3593	9	1	5310	26	HIF1A
4.327e-02	-3.14	transmembrane receptor protein tyrosine kinase adaptor activity	molecular function	GO:0005068	17	1	18094	47	BLNK
4.327e-02	-3.14	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	47	PTPN6
4.327e-02	-3.14	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	47	PTPN6
4.377e-02	-3.13	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	15	16828	45	DOCK2,ELMO1,CD74,ASS1,DENND1B,ARHGAP15,HIF1A,WDFY4,BLNK,GAB1,SKAP1,PDE11A,RIN3,PLCG2,AKAP13
4.381e-02	-3.13	ACTN1 (actinin alpha 1)	protein interactions	87	312	3	19454	49	TLN1,GIT2,PTPN6
4.397e-02	-3.12	positive regulation of cell-substrate adhesion	biological process	GO:0010811	124	2	18204	49	PREX1,SKAP1
4.406e-02	-3.12	Thyroglobulin_1_sf	interpro domains	IPR036857	17	1	18521	49	CD74
4.406e-02	-3.12	PAC	interpro domains	IPR001610	17	1	18521	49	HIF1A
4.406e-02	-3.12	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	49	ADCY7
4.406e-02	-3.12	Thyroglobulin_1	interpro domains	IPR000716	17	1	18521	49	CD74
4.406e-02	-3.12	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	1	18521	49	PLCG2
4.406e-02	-3.12	cDENN_dom	interpro domains	IPR001194	17	1	18521	49	DENND1B
4.416e-02	-3.12	ECPAS (Ecm29 proteasome adaptor and scaffold)	protein interactions	23392	313	3	19454	49	VAV1,HIF1A,P2RY6
4.440e-02	-3.11	MFSD3 (major facilitator superfamily domain containing 3)	protein interactions	113655	18	1	19454	49	PTAFR
4.440e-02	-3.11	PCDHA11 (protocadherin alpha 11)	protein interactions	56138	18	1	19454	49	RIN3
4.440e-02	-3.11	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	49	APOE
4.440e-02	-3.11	CSRP3 (cysteine and glycine rich protein 3)	protein interactions	8048	18	1	19454	49	RIN3
4.440e-02	-3.11	ZKSCAN7 (zinc finger with KRAB and SCAN domains 7)	protein interactions	55888	18	1	19454	49	PLCG2
4.440e-02	-3.11	DCAF17 (DDB1 and CUL4 associated factor 17)	protein interactions	80067	18	1	19454	49	PREX1
4.440e-02	-3.11	BEX4 (brain expressed X-linked 4)	protein interactions	56271	18	1	19454	49	PRKCD
4.440e-02	-3.11	GALM (galactose mutarotase)	protein interactions	130589	18	1	19454	49	AKAP13
4.440e-02	-3.11	Chmp6 (charged multivesicular body protein 6)	protein interactions	208092	18	1	19454	49	PTPN6
4.440e-02	-3.11	TM4SF20 (transmembrane 4 L six family member 20)	protein interactions	79853	18	1	19454	49	CD74
4.451e-02	-3.11	anatomical structure development	biological process	GO:0048856	5207	20	18204	49	SEMA4A,ASS1,APOE,SYK,PTPN6,GSDME,GIT2,SBNO2,BLNK,VAV1,CSF1R,HIF1A,AKAP13,IL6R,PLCG2,PREX1,GAB1,CDH18,CD74,DOCK2
4.457e-02	-3.11	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	4	16828	45	SYK,CSF1R,PRKCD,NEK6
4.461e-02	-3.11	mammary gland development	biological process	GO:0030879	125	2	18204	49	HIF1A,CSF1R
4.461e-02	-3.11	regulation of cell-matrix adhesion	biological process	GO:0001952	125	2	18204	49	TLN1,SKAP1
4.476e-02	-3.11	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	37	VAV1,GAB1
4.481e-02	-3.11	cell population proliferation	biological process	GO:0008283	726	5	18204	49	PRKCD,DOCK2,PTPN6,HIF1A,CSF1R
4.481e-02	-3.11	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	49	APOE
4.481e-02	-3.11	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	49	IL6R
4.481e-02	-3.11	negative regulation of humoral immune response	biological process	GO:0002921	17	1	18204	49	PTPN6
4.481e-02	-3.11	axonal transport of mitochondrion	biological process	GO:0019896	17	1	18204	49	HIF1A
4.481e-02	-3.11	regulation of integrin activation	biological process	GO:0033623	17	1	18204	49	SKAP1
4.481e-02	-3.11	reverse cholesterol transport	biological process	GO:0043691	17	1	18204	49	APOE
4.481e-02	-3.11	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	49	APOE
4.481e-02	-3.11	negative regulation of receptor internalization	biological process	GO:0002091	17	1	18204	49	RIN3
4.481e-02	-3.11	monocyte differentiation	biological process	GO:0030224	17	1	18204	49	CSF1R
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	P2RY2
4.481e-02	-3.11	regulation of excitatory synapse assembly	biological process	GO:1904889	17	1	18204	49	SEMA4A
4.481e-02	-3.11	regulation of dendritic cell cytokine production	biological process	GO:0002730	17	1	18204	49	PLCG2
4.481e-02	-3.11	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	49	HIF1A
4.481e-02	-3.11	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	49	APOE
4.481e-02	-3.11	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902165	17	1	18204	49	CD74
4.481e-02	-3.11	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	49	APOE
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	CD74
4.481e-02	-3.11	regulation of plasma membrane organization	biological process	GO:1903729	17	1	18204	49	PRKCD
4.481e-02	-3.11	response to hepatocyte growth factor	biological process	GO:0035728	17	1	18204	49	GAB1
4.481e-02	-3.11	regulation of amyloid fibril formation	biological process	GO:1905906	17	1	18204	49	APOE
4.481e-02	-3.11	CD4-positive, alpha-beta T cell lineage commitment	biological process	GO:0043373	17	1	18204	49	IL6R
4.481e-02	-3.11	ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)	protein interactions	476	533	4	19454	49	P2RY6,VAV1,TLN1,RIN3
4.486e-02	-3.10	DARS1 (aspartyl-tRNA synthetase 1)	protein interactions	1615	315	3	19454	49	PRKCD,TLN1,PTPN6
4.493e-02	-3.10	myeloid cell differentiation	biological process	GO:0030099	295	3	18204	49	PTPN6,SBNO2,CSF1R
4.507e-02	-3.10	RPL6 (ribosomal protein L6)	protein interactions	6128	534	4	19454	49	PTPN6,RIN3,APOE,NCK1
4.517e-02	-3.10	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	44	SYK,CSF1R
4.547e-02	-3.09	phosphorylation	biological process	GO:0016310	729	5	18204	49	SYK,PRKCD,CSF1R,NEK6,PTPN6
4.547e-02	-3.09	GLUL (glutamate-ammonia ligase)	protein interactions	2752	135	2	19454	49	TLN1,RIN3
4.547e-02	-3.09	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	2	19454	49	NCK1,GAB1
4.554e-02	-3.09	nodular	COSMIC cancer mutations	nodular	1515	8	16828	45	AKAP13,BLNK,ARHGAP15,RIN3,DOCK2,CDH18,ARHGAP27,SYK
4.556e-02	-3.09	LDHA (lactate dehydrogenase A)	protein interactions	3939	317	3	19454	49	ASS1,RIN3,HIF1A
4.576e-02	-3.08	endopeptidase activator activity	molecular function	GO:0061133	18	1	18094	47	VSIR
4.576e-02	-3.08	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	47	APOE
4.580e-02	-3.08	FCGR activation	REACTOME pathways	R-HSA-2029481	13	1	10285	37	SYK
4.581e-02	-3.08	Thyroglobulin_1	pfam domains	PF00086	17	1	17795	49	CD74
4.581e-02	-3.08	PI-PLC-X	pfam domains	PF00388	17	1	17795	49	PLCG2
4.581e-02	-3.08	DENN	pfam domains	PF02141	17	1	17795	49	DENND1B
4.590e-02	-3.08	cellular response to toxic substance	biological process	GO:0097237	127	2	18204	49	IPCEF1,APOE
4.590e-02	-3.08	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	49	TLN1,CDH18
4.592e-02	-3.08	TRIM54 (tripartite motif containing 54)	protein interactions	57159	318	3	19454	49	NEK6,ELMO1,PARVG
4.592e-02	-3.08	SRPRB (SRP receptor subunit beta)	protein interactions	58477	318	3	19454	49	HIF1A,RIN3,VAV1
4.608e-02	-3.08	PYGB (glycogen phosphorylase B)	protein interactions	5834	136	2	19454	49	PRKCD,FYB1
4.608e-02	-3.08	IRS1 (insulin receptor substrate 1)	protein interactions	3667	136	2	19454	49	PLCG2,PRKCD
4.608e-02	-3.08	ROCK2 (Rho associated coiled-coil containing protein kinase 2)	protein interactions	9475	136	2	19454	49	TLN1,AKAP13
4.608e-02	-3.08	ITGB5 (integrin subunit beta 5)	protein interactions	3693	136	2	19454	49	TLN1,P2RY2
4.608e-02	-3.08	NAF1 (nuclear assembly factor 1 ribonucleoprotein)	protein interactions	92345	136	2	19454	49	RIN3,SYK
4.615e-02	-3.08	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	44	16828	45	PTAFR,GIT2,SEMA4A,EHBP1L1,APOE,PRKCD,P2RY6,SKAP1,GAB1,WDFY4,IPCEF1,ASS1,ARHGAP15,IRF5,CD74,ARHGAP27,MYO1F,PIK3R5,ELMO1,RHBDF2,CDH18,RIN3,GMIP,SBNO2,ARAP1,DOCK2,SYK,TLN1,ADCY7,NEK6,PREX1,ARHGAP33,PTPN6,PARVG,PLCG2,AKAP13,VAV1,P2RY2,HIF1A,BLNK,CSF1R,PDE11A,NCK1,IL6R
4.615e-02	-3.08	bile_duct	COSMIC cancer mutations	bile_duct	15095	44	16828	45	IPCEF1,P2RY6,PRKCD,SKAP1,WDFY4,GAB1,SEMA4A,APOE,EHBP1L1,PTAFR,GIT2,CDH18,RHBDF2,PIK3R5,ELMO1,CD74,ARHGAP27,IRF5,MYO1F,ARHGAP15,ASS1,GMIP,RIN3,ARAP1,DOCK2,SBNO2,TLN1,ADCY7,SYK,PTPN6,PARVG,ARHGAP33,PREX1,NEK6,HIF1A,PDE11A,NCK1,CSF1R,BLNK,P2RY2,VAV1,PLCG2,AKAP13,IL6R
4.621e-02	-3.07	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	4	16828	45	SYK,CSF1R,PRKCD,NEK6
4.624e-02	-3.07	cellular response to hormone stimulus	biological process	GO:0032870	504	4	18204	49	PRKCD,GAB1,ASS1,P2RY6
4.627e-02	-3.07	GCN1 (GCN1 activator of EIF2AK4)	protein interactions	10985	319	3	19454	49	P2RY6,HIF1A,NEK6
4.627e-02	-3.07	UBXN6 (UBX domain protein 6)	protein interactions	80700	319	3	19454	49	EHBP1L1,GIT2,ARAP1
4.630e-02	-3.07	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	739	5	16828	45	PLCG2,CSF1R,CDH18,PTPN6,DOCK2
4.630e-02	-3.07	acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_T_cell_leukaemia	739	5	16828	45	PLCG2,CSF1R,CDH18,DOCK2,PTPN6
4.633e-02	-3.07	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	3	16828	45	DOCK2,ARHGAP15,WDFY4
4.636e-02	-3.07	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	4	12186	44	CSF1R,NEK6,PRKCD,SYK
4.655e-02	-3.07	regulation of protein binding	biological process	GO:0043393	128	2	18204	49	PRKCD,APOE
4.659e-02	-3.07	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	49	ADCY7
4.659e-02	-3.07	A/G_cyclase	interpro domains	IPR001054	18	1	18521	49	ADCY7
4.663e-02	-3.07	SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2)	protein interactions	6595	320	3	19454	49	HIF1A,ASS1,ARHGAP33
4.681e-02	-3.06	ZNF197 (zinc finger protein 197)	protein interactions	10168	19	1	19454	49	HIF1A
4.681e-02	-3.06	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	49	PRKCD
4.681e-02	-3.06	RCVRN (recoverin)	protein interactions	5957	19	1	19454	49	GIT2
4.681e-02	-3.06	PPRC1 (PPARG related coactivator 1)	protein interactions	23082	19	1	19454	49	PRKCD
4.681e-02	-3.06	PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2)	protein interactions	57546	19	1	19454	49	PRKCD
4.681e-02	-3.06	SLITRK3 (SLIT and NTRK like family member 3)	protein interactions	22865	19	1	19454	49	RHBDF2
4.681e-02	-3.06	PEX2 (peroxisomal biogenesis factor 2)	protein interactions	5828	19	1	19454	49	PTPN6
4.681e-02	-3.06	SIT1 (signaling threshold regulating transmembrane adaptor 1)	protein interactions	27240	19	1	19454	49	SYK
4.681e-02	-3.06	CSF1 (colony stimulating factor 1)	protein interactions	1435	19	1	19454	49	CSF1R
4.699e-02	-3.06	TXN (thioredoxin)	protein interactions	7295	321	3	19454	49	PTPN6,ASS1,RIN3
4.720e-02	-3.05	positive regulation of lymphocyte mediated immunity	biological process	GO:0002708	129	2	18204	49	VAV1,DENND1B
4.735e-02	-3.05	ITGB1 (integrin subunit beta 1)	protein interactions	3688	322	3	19454	49	RHBDF2,TLN1,P2RY6
4.737e-02	-3.05	circulatory system process	biological process	GO:0003013	508	4	18204	49	APOE,AKAP13,PTAFR,P2RY2
4.738e-02	-3.05	positive regulation of neuroinflammatory response	biological process	GO:0150078	18	1	18204	49	PLCG2
4.738e-02	-3.05	regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002923	18	1	18204	49	PTPN6
4.738e-02	-3.05	regulation of granulocyte macrophage colony-stimulating factor production	biological process	GO:0032645	18	1	18204	49	SYK
4.738e-02	-3.05	morphogenesis of an epithelial fold	biological process	GO:0060571	18	1	18204	49	HIF1A
4.738e-02	-3.05	positive regulation of vascular endothelial growth factor receptor signaling pathway	biological process	GO:0030949	18	1	18204	49	HIF1A
4.738e-02	-3.05	cell-cell junction maintenance	biological process	GO:0045217	18	1	18204	49	CSF1R
4.738e-02	-3.05	antifungal innate immune response	biological process	GO:0061760	18	1	18204	49	PLCG2
4.738e-02	-3.05	gamma-delta T cell activation	biological process	GO:0046629	18	1	18204	49	SYK
4.738e-02	-3.05	regulation of leukocyte tethering or rolling	biological process	GO:1903236	18	1	18204	49	PTAFR
4.764e-02	-3.04	protein phosphatase type 1 complex	cellular component	GO:0000164	19	1	19108	49	NCK1
4.765e-02	-3.04	-	gene3d domains	2.60.200.10	15	1	14470	47	IRF5
4.765e-02	-3.04	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	5	16828	45	CDH18,ARHGAP27,HIF1A,PDE11A,AKAP13
4.768e-02	-3.04	HAPSTR1 (HUWE1 associated protein modifying stress responses)	protein interactions	29035	544	4	19454	49	TLN1,VAV1,CD74,ASS1
4.771e-02	-3.04	ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2)	protein interactions	488	323	3	19454	49	APOE,RIN3,P2RY6
4.771e-02	-3.04	COPE (COPI coat complex subunit epsilon)	protein interactions	11316	323	3	19454	49	P2RY6,VAV1,CD74
4.792e-02	-3.04	MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking)	protein interactions	23041	139	2	19454	49	P2RY6,HIF1A
4.792e-02	-3.04	ACADM (acyl-CoA dehydrogenase medium chain)	protein interactions	34	139	2	19454	49	ASS1,P2RY6
4.792e-02	-3.04	PTPRA (protein tyrosine phosphatase receptor type A)	protein interactions	5786	139	2	19454	49	GAB1,PRKCD
4.794e-02	-3.04	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	26	APOE
4.797e-02	-3.04	Signaling events mediated by TCPTP	Pathway Interaction DB	tcptp_pathway	36	2	2226	22	GAB1,CSF1R
4.817e-02	-3.03	atypical	COSMIC cancer mutations	atypical	515	4	16828	45	SYK,PRKCD,NEK6,CSF1R
4.824e-02	-3.03	regulation of apoptotic process	biological process	GO:0042981	1518	8	18204	49	IRF5,HIF1A,CSF1R,PRKCD,NCK1,GSDME,PTPN6,CD74
4.835e-02	-3.03	coated vesicle	cellular component	GO:0030135	319	3	19108	49	APOE,DENND1B,CD74
4.838e-02	-3.03	TYRKINASE	prints domains	PR00109	98	2	5227	19	SYK,NEK6
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY7
4.852e-02	-3.03	digestive tract development	biological process	GO:0048565	131	2	18204	49	HIF1A,ASS1
4.853e-02	-3.03	USP19 (ubiquitin specific peptidase 19)	protein interactions	10869	140	2	19454	49	HIF1A,TLN1
4.853e-02	-3.03	RPS6KB1 (ribosomal protein S6 kinase B1)	protein interactions	6198	140	2	19454	49	NEK6,SYK
4.884e-02	-3.02	clathrin-coated vesicle membrane	cellular component	GO:0030665	138	2	19108	49	CD74,APOE
4.910e-02	-3.01	secretory granule lumen	cellular component	GO:0034774	321	3	19108	49	PRKCD,DOCK2,PTPN6
4.910e-02	-3.01	Kinase-like_dom_sf	interpro domains	IPR011009	523	4	18521	49	NEK6,PRKCD,SYK,CSF1R
4.911e-02	-3.01	PDEase	interpro domains	IPR023088	19	1	18521	49	PDE11A
4.911e-02	-3.01	PAS_fold	interpro domains	IPR013767	19	1	18521	49	HIF1A
4.916e-02	-3.01	PELO (pelota mRNA surveillance and ribosome rescue factor)	protein interactions	53918	141	2	19454	49	HIF1A,P2RY6
4.916e-02	-3.01	ATP5IF1 (ATP synthase inhibitory factor subunit 1)	protein interactions	93974	141	2	19454	49	P2RY6,P2RY2
4.916e-02	-3.01	ARHGAP32 (Rho GTPase activating protein 32)	protein interactions	9743	141	2	19454	49	NCK1,GAB1
4.916e-02	-3.01	defense response to bacterium	biological process	GO:0042742	306	3	18204	49	PRKCD,SYK,IL6R
4.917e-02	-3.01	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	3	19454	49	PTPN6,NCK1,RHBDF2
4.921e-02	-3.01	RGS4 (regulator of G protein signaling 4)	protein interactions	5999	20	1	19454	49	PTAFR
4.921e-02	-3.01	ATG9B (autophagy related 9B)	protein interactions	285973	20	1	19454	49	TLN1
4.921e-02	-3.01	NUTM2F (NUT family member 2F)	protein interactions	54754	20	1	19454	49	NCK1
4.921e-02	-3.01	SAXO5 (stabilizer of axonemal microtubules 5)	protein interactions	374877	20	1	19454	49	NEK6
4.921e-02	-3.01	H2BC12L (H2B clustered histone 12 like)	protein interactions	54145	20	1	19454	49	PRKCD
4.922e-02	-3.01	skin-axilla-malignant_melanoma	COSMIC cancer mutations	skin-axilla-malignant_melanoma	133	2	16828	45	IPCEF1,ELMO1
4.923e-02	-3.01	Regulation of IFNG signaling	REACTOME pathways	R-HSA-877312	14	1	10285	37	PTPN6
4.923e-02	-3.01	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	37	NCK1
4.923e-02	-3.01	Activation of Rac	REACTOME pathways	R-HSA-428540	14	1	10285	37	NCK1
4.934e-02	-3.01	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	45	16828	45	PIK3R5,ELMO1,RHBDF2,CDH18,ASS1,ARHGAP15,CD74,IRF5,ARHGAP27,MYO1F,GAB1,SKAP1,WDFY4,PRKCD,P2RY6,IPCEF1,GIT2,PTAFR,APOE,EHBP1L1,SEMA4A,SBNO2,DOCK2,ARAP1,GMIP,RIN3,ARHGAP33,PARVG,PTPN6,NEK6,PREX1,ADCY7,TLN1,SYK,DENND1B,IL6R,BLNK,PDE11A,CSF1R,NCK1,HIF1A,AKAP13,PLCG2,VAV1,P2RY2
4.943e-02	-3.01	human chr5p13.1	chromosome location	human chr5p13.1	27	1	26134	49	FYB1
4.943e-02	-3.01	human chr10q11.23	chromosome location	human chr10q11.23	27	1	26134	49	WDFY4
4.963e-02	-3.00	skin-genital-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-genital-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-lower_leg-other-keratoacanthoma	COSMIC cancer mutations	skin-lower_leg-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-arm-other-keratoacanthoma	COSMIC cancer mutations	skin-arm-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-back-other-keratoacanthoma	COSMIC cancer mutations	skin-back-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-chest-other-keratoacanthoma	COSMIC cancer mutations	skin-chest-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	genital	COSMIC cancer mutations	genital	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-chest-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-chest-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-leg-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-leg-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-upper_leg-other-keratoacanthoma	COSMIC cancer mutations	skin-upper_leg-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-upper_arm-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-upper_arm-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-face-other-keratoacanthoma	COSMIC cancer mutations	skin-face-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-lip-other-keratoacanthoma	COSMIC cancer mutations	skin-lip-other-keratoacanthoma	19	1	16828	45	CSF1R
4.978e-02	-3.00	SACM1L (SAC1 like phosphatidylinositide phosphatase)	protein interactions	22908	142	2	19454	49	P2RY6,P2RY2
4.978e-02	-3.00	GIT1 (GIT ArfGAP 1)	protein interactions	28964	142	2	19454	49	GIT2,NCK1
4.983e-02	-3.00	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	49	CSF1R,SYK
4.985e-02	-3.00	positive regulation of adaptive immune response	biological process	GO:0002821	133	2	18204	49	DENND1B,SKAP1
4.985e-02	-3.00	positive regulation of endothelial cell migration	biological process	GO:0010595	133	2	18204	49	GAB1,HIF1A
4.985e-02	-3.00	positive regulation of translation	biological process	GO:0045727	133	2	18204	49	NCK1,PTAFR
4.995e-02	-3.00	adenylate cyclase-activating adrenergic receptor signaling pathway	biological process	GO:0071880	19	1	18204	49	AKAP13
4.995e-02	-3.00	response to hydroperoxide	biological process	GO:0033194	19	1	18204	49	PRKCD
4.995e-02	-3.00	regulation of mast cell activation	biological process	GO:0033003	19	1	18204	49	PTPN6
4.995e-02	-3.00	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	49	APOE
4.995e-02	-3.00	alpha-beta T cell lineage commitment	biological process	GO:0002363	19	1	18204	49	IL6R
4.995e-02	-3.00	regulation of protein neddylation	biological process	GO:2000434	19	1	18204	49	HIF1A
4.995e-02	-3.00	regulation of translation in response to stress	biological process	GO:0043555	19	1	18204	49	NCK1
4.995e-02	-3.00	regulation of B cell apoptotic process	biological process	GO:0002902	19	1	18204	49	CD74
4.995e-02	-3.00	positive regulation of cellular extravasation	biological process	GO:0002693	19	1	18204	49	PTAFR
4.995e-02	-3.00	regulation of amyloid-beta clearance	biological process	GO:1900221	19	1	18204	49	APOE
4.995e-02	-3.00	leukotriene biosynthetic process	biological process	GO:0019370	19	1	18204	49	SYK
4.995e-02	-3.00	positive regulation of reactive oxygen species biosynthetic process	biological process	GO:1903428	19	1	18204	49	PLCG2
4.995e-02	-3.00	production of molecular mediator involved in inflammatory response	biological process	GO:0002532	19	1	18204	49	SYK
4.995e-02	-3.00	positive regulation of bone resorption	biological process	GO:0045780	19	1	18204	49	SYK
4.995e-02	-3.00	positive regulation of macrophage chemotaxis	biological process	GO:0010759	19	1	18204	49	CSF1R
4.997e-02	-3.00	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	22	16828	45	VAV1,AKAP13,GIT2,PLCG2,PTAFR,GMIP,ADCY7,SKAP1,BLNK,TLN1,PREX1,IRF5,MYO1F,ARHGAP15,DENND1B,DOCK2,CDH18,ARAP1,RHBDF2,ARHGAP33,PIK3R5,ELMO1
5.000e-02	-3.00	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	10	16828	45	PDE11A,ELMO1,SKAP1,GAB1,GMIP,DOCK2,IPCEF1,ARHGAP15,RIN3,AKAP13
5.000e-02	-3.00	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	10	16828	45	AKAP13,ARHGAP15,RIN3,PDE11A,GAB1,SKAP1,ELMO1,DOCK2,IPCEF1,GMIP