Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.332e-08	-18.13	plasma membrane	cellular component	GO:0005886	5538	33	19108	48	MYO1F,ARHGAP15,RAC2,SLCO2B1,GAS7,ELMO1,CTSB,NCF1,PLXND1,ITGB2,CD74,SH2B3,FYB1,NCAM2,RAPGEF6,PREX1,WDFY3,ZNRF2,CSF1R,PLEK,ITGAX,DAPP1,LPP,ENTPD1,CD68,SMPD4,ITM2B,RGS19,CMTM6,MARCO,P2RY6,NCKAP1L,HCK
2.486e-08	-17.51	cell periphery	cellular component	GO:0071944	6020	34	19108	48	CTSB,PLXND1,NCF1,FYB1,SH2B3,CD74,ITGB2,WDFY3,PREX1,RAPGEF6,NCAM2,RAC2,ARHGAP15,MYO1F,SLCO2B1,ELMO1,GAS7,SMPD4,P2RY6,MARCO,CMTM6,ITM2B,RGS19,HCK,NCKAP1L,PLEK,CSF1R,ZNRF2,DAPP1,ITGAX,ENTPD1,MYO9B,LPP,CD68
8.817e-08	-16.24	membrane	cellular component	GO:0016020	9220	41	19108	48	GCH1,CD68,LPP,MYO9B,ENTPD1,ITGAX,DAPP1,ZNRF2,CSF1R,PLEK,HCK,NCKAP1L,RGS19,ITM2B,QSOX1,CMTM6,TFEB,MARCO,P2RY6,SMPD4,GAS7,ELMO1,ABR,UNC93B1,SLCO2B1,NDUFS2,MYO1F,ARHGAP15,RAC2,RAPGEF6,NCAM2,WDFY3,PREX1,CD74,ITGB2,SH2B3,MFNG,FYB1,NCF1,PLXND1,CTSB
1.876e-07	-15.49	PH-like_dom_sf	interpro domains	IPR011993	431	10	18521	50	PREX1,GULP1,SH2B3,PLEK,WDFY3,GAB1,DAPP1,ABR,ARHGAP15,ELMO1
3.893e-07	-14.76	NHLRC2 (NHL repeat containing 2)	protein interactions	374354	372	9	19454	50	PLEK,ITGAX,ARHGAP15,CTSB,TFEB,MYO1F,RAC2,NCKAP1L,MYO9B
4.960e-07	-14.52	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	gene3d domains	2.30.29.30	431	10	14470	44	GULP1,GAB1,PLEK,WDFY3,SH2B3,DAPP1,ELMO1,ABR,ARHGAP15,PREX1
5.191e-07	-14.47	PH_domain	interpro domains	IPR001849	266	8	18521	50	ABR,ARHGAP15,ELMO1,GAB1,PREX1,SH2B3,DAPP1,PLEK
1.906e-06	-13.17	immune system process	biological process	GO:0002376	1991	18	18204	49	GCH1,FYB1,ZFP36L1,SH2B3,HCK,CSF1R,TFEB,CD74,MARCO,NCF1,MFNG,RAC2,TNFAIP8L2,UNC93B1,NCKAP1L,ITGB2,CD68,PREX1
2.561e-06	-12.88	phagocytosis, engulfment	biological process	GO:0006911	36	4	18204	49	MARCO,ITGB2,GULP1,ELMO1
4.141e-06	-12.39	phagocytosis	biological process	GO:0006909	159	6	18204	49	ELMO1,GULP1,ITGB2,P2RY6,MARCO,HCK
5.827e-06	-12.05	integrin-mediated signaling pathway	biological process	GO:0007229	96	5	18204	49	ITGB2,ITGAX,PLEK,HCK,FYB1
6.179e-06	-11.99	integrin alphaX-beta2 complex	cellular component	GO:0034689	2	2	19108	48	ITGAX,ITGB2
6.364e-06	-11.96	plasma membrane invagination	biological process	GO:0099024	45	4	18204	49	ELMO1,ITGB2,GULP1,MARCO
6.821e-06	-11.90	vacuole	cellular component	GO:0005773	857	11	19108	48	TNFAIP8L2,TFEB,NCF1,CMTM6,ZNRF2,CTSB,WDFY3,CD68,HCK,UNC93B1,CD74
1.055e-05	-11.46	regulation of granulocyte chemotaxis	biological process	GO:0071622	51	4	18204	49	NCKAP1L,RAC2,CD74,CSF1R
1.140e-05	-11.38	membrane invagination	biological process	GO:0010324	52	4	18204	49	MARCO,GULP1,ITGB2,ELMO1
1.186e-05	-11.34	regulation of catalytic activity	biological process	GO:0050790	1395	14	18204	49	CSF1R,ARHGAP15,CD74,NCF1,PLEK,NCKAP1L,ITGB2,PREX1,SPOCK3,ABR,RAPGEF6,GCH1,PLXND1,P2RY6
1.204e-05	-11.33	hemopoiesis	biological process	GO:0030097	688	10	18204	49	PREX1,RBM47,SH2B3,PLEK,NCKAP1L,RAC2,MFNG,ZFP36L1,CSF1R,CD74
1.354e-05	-11.21	response to stimulus	biological process	GO:0050896	7803	36	18204	49	GAB1,PREX1,DAPP1,SMPD4,RAC2,ARHGAP15,CSF1R,MARCO,CD74,ITGB2,CD68,TNFAIP8L2,NCKAP1L,HCK,RGS19,GCH1,FYB1,P2RY6,SLCO2B1,NDUFS2,RAPGEF6,MYO9B,ABR,ELMO1,ITGAX,MFNG,TFEB,NCF1,PLEK,UNC93B1,CTSB,ZFP36L1,ENTPD1,CPN1,SH2B3,PLXND1
1.585e-05	-11.05	lytic vacuole	cellular component	GO:0000323	762	10	19108	48	CMTM6,NCF1,TFEB,TNFAIP8L2,CTSB,ZNRF2,CD68,CD74,UNC93B1,HCK
1.585e-05	-11.05	lysosome	cellular component	GO:0005764	762	10	19108	48	ZNRF2,CTSB,NCF1,CMTM6,TNFAIP8L2,TFEB,CD74,UNC93B1,HCK,CD68
1.927e-05	-10.86	response to external stimulus	biological process	GO:0009605	1882	16	18204	49	HCK,GCH1,ITGAX,PREX1,GAB1,UNC93B1,NCKAP1L,TNFAIP8L2,CD68,ITGB2,NCF1,CD74,MARCO,TFEB,CSF1R,RAC2
1.950e-05	-10.85	cytoplasmic vesicle	cellular component	GO:0031410	2521	18	19108	48	CTSB,CMTM6,QSOX1,ITM2B,NCF1,RGS19,MARCO,ITGB2,CD74,NCKAP1L,HCK,RAPGEF6,ZNRF2,ITGAX,RAC2,UNC93B1,GCH1,CD68
2.015e-05	-10.81	intracellular vesicle	cellular component	GO:0097708	2527	18	19108	48	ZNRF2,RAC2,ITGAX,UNC93B1,GCH1,CD68,CTSB,MARCO,CMTM6,QSOX1,ITM2B,NCF1,RGS19,HCK,NCKAP1L,CD74,ITGB2,RAPGEF6
2.560e-05	-10.57	PH	smart domains	SM00233	259	7	9717	34	ARHGAP15,PREX1,SH2B3,DAPP1,GAB1,PLEK,ABR
3.515e-05	-10.26	regulation of cell shape	biological process	GO:0008360	139	5	18204	49	HCK,CSF1R,ARHGAP15,ITGB2,PLXND1
3.565e-05	-10.24	positive regulation of neutrophil chemotaxis	biological process	GO:0090023	24	3	18204	49	NCKAP1L,CD74,RAC2
3.565e-05	-10.24	respiratory burst	biological process	GO:0045730	24	3	18204	49	RAC2,HCK,NCF1
4.024e-05	-10.12	cellular response to stimulus	biological process	GO:0051716	6307	31	18204	49	PREX1,GAB1,ARHGAP15,CSF1R,CD74,MARCO,DAPP1,RAC2,SMPD4,NCKAP1L,ITGB2,CD68,HCK,RGS19,FYB1,P2RY6,SLCO2B1,NDUFS2,ITGAX,ELMO1,ABR,RAPGEF6,MYO9B,TFEB,NCF1,UNC93B1,PLEK,CTSB,ZFP36L1,PLXND1,SH2B3
4.562e-05	-10.00	positive regulation of granulocyte chemotaxis	biological process	GO:0071624	26	3	18204	49	RAC2,CD74,NCKAP1L
5.420e-05	-9.82	SH3 Domains	gene3d domains	2.30.30.40	223	6	14470	44	FYB1,GAS7,MYO1F,ELMO1,NCF1,HCK
5.427e-05	-9.82	bounding membrane of organelle	cellular component	GO:0098588	2198	16	19108	48	MARCO,TFEB,QSOX1,CMTM6,ITM2B,SMPD4,WDFY3,NCKAP1L,MFNG,ITGB2,CD74,RAC2,ITGAX,ZNRF2,CD68,UNC93B1
6.099e-05	-9.70	phosphatidylinositol-3,4-bisphosphate binding	molecular function	GO:0043325	29	3	18094	48	NCF1,PLEK,DAPP1
6.416e-05	-9.65	small GTPase-mediated signal transduction	biological process	GO:0007264	258	6	18204	49	RGS19,RAC2,ELMO1,ABR,MYO9B,RAPGEF6
6.807e-05	-9.59	EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon)	protein interactions	8893	167	5	19454	50	MYO9B,UNC93B1,P2RY6,CD74,CD68
8.704e-05	-9.35	positive regulation of catalytic activity	biological process	GO:0043085	868	10	18204	49	P2RY6,ITGB2,PLEK,GCH1,CSF1R,NCF1,CD74,RAPGEF6,ABR,PREX1
9.020e-05	-9.31	amyloid-beta binding	molecular function	GO:0001540	89	4	18094	48	CD74,ITGB2,ITM2B,MARCO
9.447e-05	-9.27	positive regulation of neutrophil migration	biological process	GO:1902624	33	3	18204	49	NCKAP1L,RAC2,CD74
9.447e-05	-9.27	regulation of neutrophil chemotaxis	biological process	GO:0090022	33	3	18204	49	NCKAP1L,RAC2,CD74
9.493e-05	-9.26	cell-cell adhesion	biological process	GO:0098609	546	8	18204	49	NCAM2,LPP,ITGAX,RAC2,ZFP36L1,ENTPD1,PLEK,ITGB2
1.012e-04	-9.20	Rho_GTPase_activation_prot	interpro domains	IPR008936	90	4	18521	50	ABR,ARHGAP15,MYO9B,PLXND1
1.088e-04	-9.13	positive regulation of leukocyte chemotaxis	biological process	GO:0002690	92	4	18204	49	NCKAP1L,CD74,CSF1R,RAC2
1.112e-04	-9.10	defense response to symbiont	biological process	GO:0140546	894	10	18204	49	TNFAIP8L2,UNC93B1,GCH1,TFEB,CSF1R,NCF1,MARCO,CD74,ITGAX,HCK
1.191e-04	-9.04	regulation of hydrolase activity	biological process	GO:0051336	726	9	18204	49	ARHGAP15,PLEK,NCKAP1L,PLXND1,P2RY6,PREX1,SPOCK3,ABR,RAPGEF6
1.390e-04	-8.88	innate immune response	biological process	GO:0045087	741	9	18204	49	TNFAIP8L2,UNC93B1,CSF1R,GCH1,TFEB,CD74,MARCO,NCF1,HCK
1.442e-04	-8.84	PH	pfam domains	PF00169	187	5	17795	48	GAB1,PLEK,ARHGAP15,DAPP1,SH2B3
1.658e-04	-8.70	positive regulation of cell migration	biological process	GO:0030335	592	8	18204	49	P2RY6,NCKAP1L,RAC2,CD74,CSF1R,ITGAX,GAB1,PREX1
1.664e-04	-8.70	regulation of molecular function	biological process	GO:0065009	2005	15	18204	49	HCK,PLXND1,P2RY6,GCH1,ABR,SPOCK3,RAPGEF6,PREX1,NCKAP1L,PLEK,ITGB2,NCF1,CD74,ARHGAP15,CSF1R
1.835e-04	-8.60	immune response	biological process	GO:0006955	1349	12	18204	49	FYB1,GCH1,HCK,CD68,UNC93B1,TNFAIP8L2,MFNG,CD74,MARCO,NCF1,TFEB,CSF1R
1.845e-04	-8.60	Rho GTPase cycle	REACTOME pathways	R-HSA-194840	142	5	10285	39	PREX1,ABR,MYO9B,RAC2,ARHGAP15
2.081e-04	-8.48	regulation of immune system process	biological process	GO:0002682	1584	13	18204	49	RBM47,HCK,CSF1R,FYB1,NCF1,CD74,RAC2,ZFP36L1,TNFAIP8L2,NCKAP1L,UNC93B1,ITGB2,CD68
2.093e-04	-8.47	MTOR (mechanistic target of rapamycin kinase)	protein interactions	2475	335	6	19454	50	ZNRF2,PREX1,UNC93B1,P2RY6,CD74,RAC2
2.097e-04	-8.47	erythrocyte development	biological process	GO:0048821	43	3	18204	49	RAC2,NCKAP1L,SH2B3
2.175e-04	-8.43	actin filament-based process	biological process	GO:0030029	616	8	18204	49	MYO9B,ELMO1,PREX1,GAS7,MYO1F,PLEK,NCKAP1L,RAC2
2.247e-04	-8.40	positive regulation of cell motility	biological process	GO:2000147	619	8	18204	49	CSF1R,CD74,RAC2,NCKAP1L,P2RY6,PREX1,GAB1,ITGAX
2.285e-04	-8.38	endocytic vesicle	cellular component	GO:0030139	349	6	19108	48	UNC93B1,CD74,MARCO,RAC2,RAPGEF6,NCF1
2.325e-04	-8.37	actin filament	cellular component	GO:0005884	120	4	19108	48	MYO9B,HCK,GAS7,RAC2
2.363e-04	-8.35	PH_DOMAIN	prosite domains	PS50003	246	6	12186	44	PREX1,GAB1,PLEK,DAPP1,ABR,ARHGAP15
2.402e-04	-8.33	regulation of neutrophil migration	biological process	GO:1902622	45	3	18204	49	NCKAP1L,CD74,RAC2
2.402e-04	-8.33	regulation of leukocyte degranulation	biological process	GO:0043300	45	3	18204	49	RAC2,NCKAP1L,ITGB2
2.473e-04	-8.31	positive regulation of immune system process	biological process	GO:0002684	986	10	18204	49	RBM47,HCK,CSF1R,FYB1,CD74,RAC2,ZFP36L1,NCKAP1L,UNC93B1,ITGB2
2.612e-04	-8.25	SH3-like_dom_sf	interpro domains	IPR036028	212	5	18521	50	MYO1F,GAS7,FYB1,HCK,NCF1
2.615e-04	-8.25	positive regulation of locomotion	biological process	GO:0040017	633	8	18204	49	GAB1,PREX1,ITGAX,RAC2,CSF1R,CD74,P2RY6,NCKAP1L
2.640e-04	-8.24	Immune System	REACTOME pathways	R-HSA-168256	2101	18	10285	39	CD68,CTSB,UNC93B1,HCK,GAB1,ELMO1,CMTM6,FYB1,ITGAX,NCKAP1L,DAPP1,ITGB2,QSOX1,CSF1R,ZNRF2,CD74,NCF1,MYO9B
2.799e-04	-8.18	EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)	protein interactions	8891	123	4	19454	50	GCH1,UNC93B1,P2RY6,CD74
2.875e-04	-8.15	FCER2 (Fc epsilon receptor II)	protein interactions	2208	10	2	19454	50	ITGAX,ITGB2
2.887e-04	-8.15	TM9SF3 (transmembrane 9 superfamily member 3)	protein interactions	56889	124	4	19454	50	P2RY6,UNC93B1,RBM47,RAC2
2.906e-04	-8.14	defense response to other organism	biological process	GO:0098542	1006	10	18204	49	HCK,ITGAX,TFEB,CSF1R,GCH1,CD74,MARCO,NCF1,TNFAIP8L2,UNC93B1
2.917e-04	-8.14	nucleoside-triphosphatase regulator activity	molecular function	GO:0060589	491	7	18094	48	ABR,MYO9B,RAPGEF6,ELMO1,ARHGAP15,PREX1,NCKAP1L
2.917e-04	-8.14	GTPase regulator activity	molecular function	GO:0030695	491	7	18094	48	ARHGAP15,PREX1,NCKAP1L,ABR,ELMO1,MYO9B,RAPGEF6
2.972e-04	-8.12	actin cytoskeleton	cellular component	GO:0015629	520	7	19108	48	RAC2,MYO1F,HCK,FYB1,MYO9B,LPP,GAS7
2.998e-04	-8.11	Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME pathways	R-HSA-2029480	86	4	10285	39	HCK,NCKAP1L,MYO9B,ELMO1
3.150e-04	-8.06	positive regulation of monocyte differentiation	biological process	GO:0045657	10	2	18204	49	CD74,ZFP36L1
3.177e-04	-8.05	defense response	biological process	GO:0006952	1431	12	18204	49	ITGB2,CD68,TNFAIP8L2,UNC93B1,TFEB,CSF1R,CD74,NCF1,MARCO,ITGAX,GCH1,HCK
3.223e-04	-8.04	regulation of leukocyte chemotaxis	biological process	GO:0002688	122	4	18204	49	CD74,CSF1R,RAC2,NCKAP1L
3.231e-04	-8.04	SH3_domain	interpro domains	IPR001452	222	5	18521	50	MYO1F,HCK,NCF1,GAS7,FYB1
3.312e-04	-8.01	signal transduction	biological process	GO:0007165	4637	24	18204	49	GAB1,PREX1,DAPP1,RAC2,CSF1R,ARHGAP15,CD74,MARCO,ITGB2,NCKAP1L,HCK,RGS19,FYB1,P2RY6,MYO9B,RAPGEF6,ITGAX,ELMO1,ABR,UNC93B1,PLEK,ZFP36L1,SH2B3,PLXND1
3.356e-04	-8.00	EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)	protein interactions	8890	129	4	19454	50	UNC93B1,P2RY6,CD74,MFNG
3.534e-04	-7.95	endocytosis	biological process	GO:0006897	499	7	18204	49	P2RY6,ITGB2,MYO1F,GULP1,MARCO,ELMO1,HCK
3.794e-04	-7.88	cellular response to chemical stimulus	biological process	GO:0070887	2411	16	18204	49	NCKAP1L,CD68,ITGB2,CD74,NCF1,CSF1R,SMPD4,PREX1,GAB1,NDUFS2,SLCO2B1,P2RY6,SH2B3,ZFP36L1,CTSB,HCK
3.844e-04	-7.86	regulation of dendritic cell antigen processing and presentation	biological process	GO:0002604	11	2	18204	49	CD68,CD74
3.867e-04	-7.86	Nef and signal transduction	REACTOME pathways	R-HSA-164944	8	2	10285	39	ELMO1,HCK
4.203e-04	-7.77	RWDD1 (RWD domain containing 1)	protein interactions	51389	12	2	19454	50	CD74,P2RY6
4.277e-04	-7.76	Chemokine signaling pathway	KEGG pathways	hsa04062	182	5	7161	26	PREX1,NCF1,HCK,RAC2,ELMO1
4.277e-04	-7.76	Chemokine signaling pathway	KEGG pathways	ko04062	182	5	7161	26	RAC2,HCK,PREX1,NCF1,ELMO1
4.300e-04	-7.75	regulation of response to stimulus	biological process	GO:0048583	4104	22	18204	49	P2RY6,SH2B3,FYB1,RGS19,GCH1,HCK,RBM47,ITGB2,UNC93B1,NCKAP1L,PLEK,TNFAIP8L2,RAC2,MFNG,MARCO,NCF1,CD74,CSF1R,ARHGAP15,MYO9B,ABR,PREX1
4.357e-04	-7.74	neutrophil chemotaxis	biological process	GO:0030593	55	3	18204	49	ITGB2,NCKAP1L,PREX1
4.834e-04	-7.63	ficolin-1-rich granule membrane	cellular component	GO:0101003	61	3	19108	48	ITGAX,NCKAP1L,ITGB2
4.958e-04	-7.61	TMEM209 (transmembrane protein 209)	protein interactions	84928	143	4	19454	50	RBM47,RAC2,P2RY6,UNC93B1
5.080e-04	-7.58	regulation of cell morphogenesis	biological process	GO:0022604	246	5	18204	49	CSF1R,ARHGAP15,HCK,PLXND1,ITGB2
5.576e-04	-7.49	positive regulation of chemotaxis	biological process	GO:0050921	141	4	18204	49	CSF1R,CD74,RAC2,NCKAP1L
5.601e-04	-7.49	cell surface receptor signaling pathway	biological process	GO:0007166	1992	14	18204	49	CSF1R,CD74,MARCO,ITGB2,PLEK,NCKAP1L,GAB1,MYO9B,ITGAX,FYB1,P2RY6,SH2B3,PLXND1,HCK
5.644e-04	-7.48	ATP1B1 (ATPase Na+/K+ transporting subunit beta 1)	protein interactions	481	148	4	19454	50	RAC2,P2RY6,UNC93B1,GCH1
5.960e-04	-7.43	DGKE (diacylglycerol kinase epsilon)	protein interactions	8526	64	3	19454	50	CD74,P2RY6,UNC93B1
5.978e-04	-7.42	Innate Immune System	REACTOME pathways	R-HSA-168249	1285	13	10285	39	MYO9B,NCF1,ITGB2,QSOX1,ELMO1,CMTM6,ITGAX,NCKAP1L,CD68,UNC93B1,CTSB,GAB1,HCK
6.118e-04	-7.40	actin cytoskeleton organization	biological process	GO:0030036	547	7	18204	49	MYO1F,GAS7,PLEK,NCKAP1L,RAC2,ELMO1,PREX1
6.194e-04	-7.39	biological process involved in interspecies interaction between organisms	biological process	GO:0044419	1540	12	18204	49	HCK,CTSB,GCH1,ITGAX,CD68,UNC93B1,TNFAIP8L2,NCF1,CD74,MARCO,CSF1R,TFEB
6.220e-04	-7.38	cytoplasm	cellular component	GO:0005737	12081	41	19108	48	NDUFS2,UNC93B1,GAS7,ABR,ELMO1,MYO1F,RAC2,ARHGAP15,ZFP36L1,CD74,ITGB2,FYB1,MFNG,GAB1,SH2B3,RAPGEF6,WDFY3,PREX1,CTSB,NOL4L,NCF1,MYO9B,LPP,GCH1,CD68,ZNRF2,PLEK,ITGAX,RBM47,DAPP1,NCKAP1L,HCK,GULP1,SMPD4,CMTM6,QSOX1,RGS19,ITM2B,TFEB,TNFAIP8L2,MARCO
6.293e-04	-7.37	SH3	smart domains	SM00326	202	5	9717	34	NCF1,MYO1F,HCK,FYB1,GAS7
6.460e-04	-7.34	cell activation	biological process	GO:0001775	725	8	18204	49	ITGB2,TNFAIP8L2,PLEK,ZFP36L1,ENTPD1,MFNG,CD74,PREX1
6.601e-04	-7.32	regulation of response to external stimulus	biological process	GO:0032101	1116	10	18204	49	TNFAIP8L2,UNC93B1,NCKAP1L,SH2B3,CSF1R,CD74,NCF1,RAC2,RBM47,HCK
6.860e-04	-7.28	positive regulation of leukocyte migration	biological process	GO:0002687	149	4	18204	49	NCKAP1L,CD74,CSF1R,RAC2
6.883e-04	-7.28	regulation of cell motility	biological process	GO:2000145	1122	10	18204	49	PLXND1,NCKAP1L,P2RY6,CSF1R,CD74,RAC2,SPOCK3,ITGAX,PREX1,GAB1
6.971e-04	-7.27	HMOX2 (heme oxygenase 2)	protein interactions	3163	276	5	19454	50	CD74,P2RY6,NDUFS2,UNC93B1,RAC2
7.044e-04	-7.26	PPP6R1 (protein phosphatase 6 regulatory subunit 1)	protein interactions	22870	157	4	19454	50	UNC93B1,P2RY6,ZNRF2,CD74
7.154e-04	-7.24	RhoGAP	pfam domains	PF00620	65	3	17795	48	ARHGAP15,ABR,MYO9B
7.188e-04	-7.24	RhoGAP_dom	interpro domains	IPR000198	65	3	18521	50	ARHGAP15,MYO9B,ABR
7.288e-04	-7.22	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	2	18204	49	P2RY6,PLEK
7.331e-04	-7.22	positive regulation of response to external stimulus	biological process	GO:0032103	564	7	18204	49	RBM47,HCK,CSF1R,CD74,RAC2,NCKAP1L,UNC93B1
7.392e-04	-7.21	regulation of actin polymerization or depolymerization	biological process	GO:0008064	152	4	18204	49	PLEK,NCKAP1L,PREX1,HCK
7.444e-04	-7.20	neutrophil migration	biological process	GO:1990266	66	3	18204	49	ITGB2,NCKAP1L,PREX1
7.585e-04	-7.18	tertiary granule	cellular component	GO:0070820	164	4	19108	48	QSOX1,ITGAX,ITGB2,NCKAP1L
7.595e-04	-7.18	GTPase activator activity	molecular function	GO:0005096	273	5	18094	48	ABR,ARHGAP15,PREX1,MYO9B,NCKAP1L
7.747e-04	-7.16	INPP5D (inositol polyphosphate-5-phosphatase D)	protein interactions	3635	70	3	19454	50	HCK,CSF1R,GAB1
7.952e-04	-7.14	regulation of actin filament length	biological process	GO:0030832	155	4	18204	49	PREX1,HCK,NCKAP1L,PLEK
8.111e-04	-7.12	cell adhesion	biological process	GO:0007155	942	9	18204	49	ITGAX,LPP,NCAM2,HCK,PLEK,ITGB2,RAC2,ZFP36L1,ENTPD1
8.131e-04	-7.11	cytoplasmic vesicle membrane	cellular component	GO:0030659	1230	10	19108	48	CD68,NCKAP1L,ITGB2,CD74,RAC2,MARCO,CMTM6,ITM2B,ITGAX,ZNRF2
8.188e-04	-7.11	response to other organism	biological process	GO:0051707	1363	11	18204	49	TFEB,CSF1R,GCH1,NCF1,CD74,MARCO,CD68,TNFAIP8L2,UNC93B1,HCK,ITGAX
8.224e-04	-7.10	Rap1 signaling pathway	KEGG pathways	ko04015	210	5	7161	26	RAC2,ITGB2,CSF1R,RAPGEF6,FYB1
8.224e-04	-7.10	Rap1 signaling pathway	KEGG pathways	hsa04015	210	5	7161	26	ITGB2,CSF1R,RAC2,RAPGEF6,FYB1
8.339e-04	-7.09	response to external biotic stimulus	biological process	GO:0043207	1366	11	18204	49	GCH1,HCK,CSF1R,TFEB,NCF1,MARCO,CD74,CD68,TNFAIP8L2,UNC93B1,ITGAX
8.673e-04	-7.05	STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A)	protein interactions	3703	166	4	19454	50	RAC2,P2RY6,UNC93B1,TFEB
8.822e-04	-7.03	regulation of GTPase activity	biological process	GO:0043087	278	5	18204	49	PREX1,ARHGAP15,RAPGEF6,PLXND1,ABR
8.822e-04	-7.03	actin filament organization	biological process	GO:0007015	278	5	18204	49	RAC2,PREX1,MYO1F,GAS7,ELMO1
9.145e-04	-7.00	regulation of locomotion	biological process	GO:0040012	1164	10	18204	49	SPOCK3,ITGAX,GAB1,PREX1,P2RY6,PLXND1,NCKAP1L,RAC2,CSF1R,CD74
9.215e-04	-6.99	NADPH oxidase complex	cellular component	GO:0043020	18	2	19108	48	RAC2,NCF1
9.264e-04	-6.98	vesicle membrane	cellular component	GO:0012506	1251	10	19108	48	NCKAP1L,ITGB2,CD74,CD68,ZNRF2,RAC2,MARCO,CMTM6,ITM2B,ITGAX
9.407e-04	-6.97	regulation of respiratory burst	biological process	GO:0060263	17	2	18204	49	RAC2,NCF1
9.442e-04	-6.97	Thyroglobulin_1	pfam domains	PF00086	17	2	17795	48	CD74,SPOCK3
9.466e-04	-6.96	Thyroglobulin_1	interpro domains	IPR000716	17	2	18521	50	CD74,SPOCK3
9.466e-04	-6.96	Thyroglobulin_1_sf	interpro domains	IPR036857	17	2	18521	50	CD74,SPOCK3
9.690e-04	-6.94	Signaling by Rho GTPases	REACTOME pathways	R-HSA-194315	426	7	10285	39	ARHGAP15,PREX1,RAC2,NCKAP1L,NCF1,ABR,MYO9B
9.762e-04	-6.93	response to chemical	biological process	GO:0042221	3743	20	18204	49	GAB1,NDUFS2,PREX1,SMPD4,RAC2,NCF1,CD74,CSF1R,CD68,ITGB2,NCKAP1L,HCK,CTSB,ZFP36L1,CPN1,RGS19,GCH1,SLCO2B1,P2RY6,SH2B3
9.812e-04	-6.93	positive regulation of leukocyte proliferation	biological process	GO:0070665	164	4	18204	49	CSF1R,CD74,RAC2,NCKAP1L
9.825e-04	-6.93	signaling	biological process	GO:0023052	4968	24	18204	49	PREX1,GAB1,ARHGAP15,CSF1R,MARCO,CD74,DAPP1,RAC2,NCKAP1L,ITGB2,HCK,RGS19,FYB1,P2RY6,ELMO1,ABR,ITGAX,RAPGEF6,MYO9B,UNC93B1,PLEK,ZFP36L1,PLXND1,SH2B3
1.050e-03	-6.86	Rho GTPase activation protein	gene3d domains	1.10.555.10	66	3	14470	44	MYO9B,ABR,ARHGAP15
1.064e-03	-6.85	RHO GTPases Activate NADPH Oxidases	REACTOME pathways	R-HSA-5668599	13	2	10285	39	RAC2,NCF1
1.071e-03	-6.84	response to biotic stimulus	biological process	GO:0009607	1408	11	18204	49	TNFAIP8L2,UNC93B1,CD68,GCH1,CSF1R,TFEB,MARCO,CD74,NCF1,ITGAX,HCK
1.091e-03	-6.82	plasma membrane region	cellular component	GO:0098590	1278	10	19108	48	PLEK,CTSB,ZNRF2,P2RY6,PLXND1,HCK,ENTPD1,SLCO2B1,ITGB2,RAPGEF6
1.097e-03	-6.82	positive regulation of molecular function	biological process	GO:0044093	1192	10	18204	49	PREX1,ABR,RAPGEF6,CSF1R,GCH1,NCF1,CD74,PLEK,ITGB2,P2RY6
1.118e-03	-6.80	cell communication	biological process	GO:0007154	5010	24	18204	49	SH2B3,PLXND1,ZFP36L1,UNC93B1,PLEK,RAPGEF6,MYO9B,ELMO1,ITGAX,ABR,P2RY6,RGS19,FYB1,HCK,ITGB2,NCKAP1L,DAPP1,RAC2,ARHGAP15,CSF1R,MARCO,CD74,GAB1,PREX1
1.162e-03	-6.76	secretory granule membrane	cellular component	GO:0030667	317	5	19108	48	ITGB2,NCKAP1L,CD68,CMTM6,ITGAX
1.168e-03	-6.75	SH3	prosite domains	PS50002	222	5	12186	44	GAS7,MYO1F,HCK,NCF1,FYB1
1.184e-03	-6.74	DMWD (DM1 locus, WD repeat containing)	protein interactions	1762	81	3	19454	50	CTSB,NDUFS2,WDFY3
1.187e-03	-6.74	ficolin-1-rich granule	cellular component	GO:0101002	185	4	19108	48	ITGAX,NCKAP1L,ITGB2,CTSB
1.194e-03	-6.73	Thyroglobulin type-1	gene3d domains	4.10.800.10	17	2	14470	44	SPOCK3,CD74
1.194e-03	-6.73	RARRES1 (retinoic acid receptor responder 1)	protein interactions	5918	20	2	19454	50	RAPGEF6,DAPP1
1.194e-03	-6.73	CREB3L2 (cAMP responsive element binding protein 3 like 2)	protein interactions	64764	20	2	19454	50	GULP1,GAS7
1.195e-03	-6.73	SCAMP3 (secretory carrier membrane protein 3)	protein interactions	10067	181	4	19454	50	RBM47,RAC2,UNC93B1,P2RY6
1.239e-03	-6.69	Trafficking and processing of endosomal TLR	REACTOME pathways	R-HSA-1679131	14	2	10285	39	CTSB,UNC93B1
1.255e-03	-6.68	myeloid cell development	biological process	GO:0061515	79	3	18204	49	SH2B3,NCKAP1L,RAC2
1.270e-03	-6.67	SAAL1 (serum amyloid A like 1)	protein interactions	113174	184	4	19454	50	CD68,P2RY6,UNC93B1,QSOX1
1.293e-03	-6.65	regulation of cell adhesion	biological process	GO:0030155	807	8	18204	49	PREX1,RAC2,CD74,ITGB2,SH2B3,TNFAIP8L2,PLXND1,NCKAP1L
1.307e-03	-6.64	regulation of monocyte differentiation	biological process	GO:0045655	20	2	18204	49	ZFP36L1,CD74
1.307e-03	-6.64	regulation of antigen processing and presentation	biological process	GO:0002577	20	2	18204	49	CD68,CD74
1.358e-03	-6.60	vacuolar membrane	cellular component	GO:0005774	490	6	19108	48	CMTM6,TFEB,ZNRF2,CD68,WDFY3,CD74
1.396e-03	-6.57	regulation of cell activation	biological process	GO:0050865	630	7	18204	49	CD74,RAC2,ZFP36L1,PLEK,NCKAP1L,TNFAIP8L2,SH2B3
1.398e-03	-6.57	granulocyte chemotaxis	biological process	GO:0071621	82	3	18204	49	PREX1,ITGB2,NCKAP1L
1.401e-03	-6.57	GTP-dependent protein binding	molecular function	GO:0030742	21	2	18094	48	RAPGEF6,GCH1
1.407e-03	-6.57	WAS (WASP actin nucleation promoting factor)	protein interactions	7454	86	3	19454	50	GAS7,FYB1,HCK
1.410e-03	-6.56	RhoGAP	smart domains	SM00324	64	3	9717	34	ABR,MYO9B,ARHGAP15
1.448e-03	-6.54	DEP	pfam domains	PF00610	21	2	17795	48	PLEK,PREX1
1.452e-03	-6.54	GDS_CDC24_CS	interpro domains	IPR001331	21	2	18521	50	ABR,PREX1
1.455e-03	-6.53	PLCG2 (phospholipase C gamma 2)	protein interactions	5336	87	3	19454	50	HCK,DAPP1,GAB1
1.484e-03	-6.51	SH2DOMAIN	prints domains	PR00401	72	3	5227	17	SH2B3,HCK,DAPP1
1.508e-03	-6.50	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	17	16828	46	LPP,NDUFS2,RAC2,ZNRF2,PLXND1,GAS7,MFNG,WDFY3,CSF1R,GAB1,TFEB,ELMO1,NCAM2,RAPGEF6,P2RY6,SPOCK3,RBM47
1.508e-03	-6.50	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	17	16828	46	ZNRF2,RAC2,GAS7,PLXND1,LPP,NDUFS2,SPOCK3,RAPGEF6,P2RY6,RBM47,MFNG,ELMO1,TFEB,GAB1,NCAM2,WDFY3,CSF1R
1.528e-03	-6.48	positive regulation of immune response	biological process	GO:0050778	640	7	18204	49	NCKAP1L,UNC93B1,ITGB2,CD74,FYB1,RBM47,HCK
1.543e-03	-6.47	CNPY3 (canopy FGF signaling regulator 3)	protein interactions	10695	194	4	19454	50	CD74,HCK,CTSB,RGS19
1.558e-03	-6.46	Regulation of actin dynamics for phagocytic cup formation	REACTOME pathways	R-HSA-2029482	61	3	10285	39	ELMO1,NCKAP1L,MYO9B
1.564e-03	-6.46	TY	smart domains	SM00211	17	2	9717	34	SPOCK3,CD74
1.594e-03	-6.44	DEP_dom	interpro domains	IPR000591	22	2	18521	50	PREX1,PLEK
1.604e-03	-6.44	IPO13 (importin 13)	protein interactions	9670	90	3	19454	50	CD74,UNC93B1,P2RY6
1.640e-03	-6.41	lymph_node	COSMIC cancer mutations	lymph_node	1703	12	16828	46	NDUFS2,HCK,CPN1,CD74,NCAM2,ELMO1,ZFP36L1,CSF1R,WDFY3,DAPP1,GULP1,SPOCK3
1.641e-03	-6.41	RHOGAP	prosite domains	PS50238	65	3	12186	44	MYO9B,ARHGAP15,ABR
1.655e-03	-6.40	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	3	19454	50	GAB1,HCK,CSF1R
1.674e-03	-6.39	THYROGLOBULIN_1_1	prosite domains	PS00484	17	2	12186	44	SPOCK3,CD74
1.674e-03	-6.39	THYROGLOBULIN_1_2	prosite domains	PS51162	17	2	12186	44	CD74,SPOCK3
1.723e-03	-6.36	ARHGAP42 (Rho GTPase activating protein 42)	protein interactions	143872	24	2	19454	50	RAC2,GCH1
1.723e-03	-6.36	GSTCD (glutathione S-transferase C-terminal domain containing)	protein interactions	79807	24	2	19454	50	CSF1R,DAPP1
1.732e-03	-6.36	amyloid-beta clearance	biological process	GO:0097242	23	2	18204	49	MARCO,ITGB2
1.752e-03	-6.35	response to organic substance	biological process	GO:0010033	2498	15	18204	49	SH2B3,P2RY6,ZFP36L1,RGS19,GCH1,CPN1,HCK,CTSB,ITGB2,CD68,SMPD4,CSF1R,NCF1,CD74,GAB1
1.758e-03	-6.34	cell development	biological process	GO:0048468	2236	14	18204	49	NCAM2,RBM47,SH2B3,GAS7,PLXND1,ZFP36L1,RAPGEF6,PREX1,NCKAP1L,PLEK,RAC2,MFNG,CSF1R,CD74
1.762e-03	-6.34	MAIP1 (matrix AAA peptidase interacting protein 1)	protein interactions	79568	93	3	19454	50	UNC93B1,NDUFS2,P2RY6
1.762e-03	-6.34	C19orf25 (chromosome 19 open reading frame 25)	protein interactions	148223	93	3	19454	50	UNC93B1,P2RY6,MFNG
1.838e-03	-6.30	intracellular signal transduction	biological process	GO:0035556	1505	11	18204	49	HCK,ZFP36L1,RGS19,SH2B3,PREX1,RAPGEF6,MYO9B,ABR,ELMO1,RAC2,PLEK
1.866e-03	-6.28	regulation of cell migration	biological process	GO:0030334	1061	9	18204	49	P2RY6,NCKAP1L,PLXND1,RAC2,CD74,CSF1R,ITGAX,GAB1,PREX1
1.888e-03	-6.27	ARCN1 (archain 1)	protein interactions	372	205	4	19454	50	P2RY6,UNC93B1,NCF1,CD74
1.911e-03	-6.26	cell differentiation	biological process	GO:0030154	3645	19	18204	49	PLXND1,LRMDA,SH2B3,GAS7,ZFP36L1,CTSB,RBM47,HCK,NCAM2,NCKAP1L,PLEK,ITGB2,CSF1R,CD74,MFNG,RAC2,RAPGEF6,PREX1,NDUFS2
1.913e-03	-6.26	human chr3q27.3-q28	chromosome location	human chr3q27.3-q28	1	1	26134	50	LPP
1.913e-03	-6.26	human chr7p14.2-p14.1	chromosome location	human chr7p14.2-p14.1	1	1	26134	50	ELMO1
1.913e-03	-6.26	human chr2q22.2-q22.3	chromosome location	human chr2q22.2-q22.3	1	1	26134	50	ARHGAP15
1.913e-03	-6.26	human chr12q13.13-q13.2	chromosome location	human chr12q13.13-q13.2	1	1	26134	50	NCKAP1L
1.913e-03	-6.26	human chr2q32.1-q32.2	chromosome location	human chr2q32.1-q32.2	1	1	26134	50	GULP1
1.913e-03	-6.26	human chr10q22.2-q22.3	chromosome location	human chr10q22.2-q22.3	1	1	26134	50	LRMDA
1.925e-03	-6.25	enzyme regulator activity	molecular function	GO:0030234	1305	10	18094	48	ARHGAP15,RAC2,NCKAP1L,SPOCK3,PREX1,ABR,RAPGEF6,MYO9B,ELMO1,NCF1
1.929e-03	-6.25	LMAN2 (lectin, mannose binding 2)	protein interactions	10960	96	3	19454	50	UNC93B1,NDUFS2,P2RY6
1.931e-03	-6.25	cellular developmental process	biological process	GO:0048869	3648	19	18204	49	ZFP36L1,GAS7,SH2B3,LRMDA,PLXND1,NCAM2,HCK,RBM47,CTSB,RAC2,MFNG,CD74,CSF1R,ITGB2,PLEK,NCKAP1L,NDUFS2,PREX1,RAPGEF6
1.956e-03	-6.24	OPALIN (oligodendrocytic myelin paranodal and inner loop protein)	protein interactions	93377	207	4	19454	50	UNC93B1,CMTM6,SMPD4,WDFY3
1.999e-03	-6.22	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	4	18204	49	CSF1R,CD74,MARCO,P2RY6
2.000e-03	-6.21	anatomical structure development	biological process	GO:0048856	5207	24	18204	49	ITM2B,ITGB2,UNC93B1,PLEK,NCKAP1L,MFNG,RAC2,TFEB,CSF1R,CD74,RAPGEF6,MYO9B,ITGAX,NDUFS2,GAB1,PREX1,SH2B3,GAS7,PLXND1,ZFP36L1,HCK,NCAM2,CTSB,RBM47
2.059e-03	-6.19	Integrin_dom_sf	interpro domains	IPR032695	25	2	18521	50	ITGAX,ITGB2
2.061e-03	-6.18	ABI1 (abl interactor 1)	protein interactions	10006	210	4	19454	50	GAS7,RAC2,NCKAP1L,NCF1
2.101e-03	-6.17	Neutrophil degranulation	REACTOME pathways	R-HSA-6798695	487	7	10285	39	CMTM6,CTSB,ITGB2,CD68,QSOX1,ITGAX,NCKAP1L
2.197e-03	-6.12	granulocyte migration	biological process	GO:0097530	96	3	18204	49	ITGB2,NCKAP1L,PREX1
2.201e-03	-6.12	regulation of actin cytoskeleton organization	biological process	GO:0032956	342	5	18204	49	CSF1R,PREX1,HCK,PLEK,NCKAP1L
2.214e-03	-6.11	ruffle organization	biological process	GO:0031529	26	2	18204	49	PLEK,CSF1R
2.217e-03	-6.11	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	9	19454	50	SH2B3,RAPGEF6,CD74,GAB1,ZFP36L1,ITGB2,GCH1,NCAM2,TFEB
2.283e-03	-6.08	HACD3 (3-hydroxyacyl-CoA dehydratase 3)	protein interactions	51495	216	4	19454	50	ARHGAP15,RAC2,UNC93B1,P2RY6
2.286e-03	-6.08	import into cell	biological process	GO:0098657	687	7	18204	49	HCK,ELMO1,MARCO,GULP1,MYO1F,ITGB2,P2RY6
2.286e-03	-6.08	chemotaxis	biological process	GO:0006935	345	5	18204	49	PREX1,GAB1,RAC2,NCKAP1L,ITGB2
2.294e-03	-6.08	FASLG (Fas ligand)	protein interactions	356	102	3	19454	50	NCF1,HCK,FYB1
2.344e-03	-6.06	taxis	biological process	GO:0042330	347	5	18204	49	GAB1,RAC2,PREX1,ITGB2,NCKAP1L
2.379e-03	-6.04	Regulation of RAC1 activity	Pathway Interaction DB	rac1_reg_pathway	39	3	2226	16	ELMO1,PREX1,ABR
2.387e-03	-6.04	positive regulation of protein tyrosine kinase activity	biological process	GO:0061098	27	2	18204	49	NCF1,CSF1R
2.388e-03	-6.04	regulation of chemotaxis	biological process	GO:0050920	209	4	18204	49	CD74,CSF1R,RAC2,NCKAP1L
2.394e-03	-6.03	DEP	smart domains	SM00049	21	2	9717	34	PREX1,PLEK
2.419e-03	-6.02	enzyme binding	molecular function	GO:0019899	2086	13	18094	48	NDUFS2,SH2B3,RAPGEF6,CSF1R,RBM47,PREX1,ITGAX,ITGB2,CD74,MYO9B,GCH1,PLEK,TFEB
2.467e-03	-6.00	hematopoietic progenitor cell differentiation	biological process	GO:0002244	100	3	18204	49	PLEK,SH2B3,RBM47
2.479e-03	-6.00	SH2	pfam domains	PF00017	100	3	17795	48	SH2B3,DAPP1,HCK
2.479e-03	-6.00	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	7	18204	49	NCKAP1L,PLEK,P2RY6,CSF1R,CD74,NCF1,MARCO
2.479e-03	-6.00	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	7	18204	49	P2RY6,NCKAP1L,PLEK,CSF1R,NCF1,MARCO,CD74
2.512e-03	-5.99	NOS2-CD74 complex	cellular component	GO:0035693	1	1	19108	48	CD74
2.514e-03	-5.99	NCF2 (neutrophil cytosolic factor 2)	protein interactions	4688	29	2	19454	50	RAC2,NCF1
2.559e-03	-5.97	SGCA (sarcoglycan alpha)	protein interactions	6442	106	3	19454	50	ITM2B,SMPD4,CMTM6
2.562e-03	-5.97	DEP	prosite domains	PS50186	21	2	12186	44	PREX1,PLEK
2.562e-03	-5.97	DH_1	prosite domains	PS00741	21	2	12186	44	PREX1,ABR
2.570e-03	-5.96	Alox12 (arachidonate 12-lipoxygenase, 12S type)	protein interactions	287454	1	1	19454	50	NCF1
2.570e-03	-5.96	SCGB3A2 (secretoglobin family 3A member 2)	protein interactions	117156	1	1	19454	50	MARCO
2.653e-03	-5.93	ITPase activity	molecular function	GO:0103023	1	1	18094	48	ENTPD1
2.653e-03	-5.93	GTP cyclohydrolase I activity	molecular function	GO:0003934	1	1	18094	48	GCH1
2.653e-03	-5.93	GTP cyclohydrolase activity	molecular function	GO:0003933	1	1	18094	48	GCH1
2.653e-03	-5.93	sphingomyelin phosphodiesterase D activity	molecular function	GO:0050290	1	1	18094	48	SMPD4
2.653e-03	-5.93	MHC class II protein binding, via antigen binding groove	molecular function	GO:0042658	1	1	18094	48	CD74
2.683e-03	-5.92	erythrocyte differentiation	biological process	GO:0030218	103	3	18204	49	SH2B3,NCKAP1L,RAC2
2.688e-03	-5.92	PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)	protein interactions	5296	226	4	19454	50	CSF1R,RAC2,HCK,GAB1
2.690e-03	-5.92	cell chemotaxis	biological process	GO:0060326	216	4	18204	49	PREX1,GAB1,NCKAP1L,ITGB2
2.692e-03	-5.92	phospholipase C-inhibiting G protein-coupled receptor signaling pathway	biological process	GO:0030845	1	1	18204	49	PLEK
2.692e-03	-5.92	response to pyrimidine ribonucleotide	biological process	GO:1905834	1	1	18204	49	P2RY6
2.692e-03	-5.92	cellular response to pyrimidine ribonucleotide	biological process	GO:1905835	1	1	18204	49	P2RY6
2.692e-03	-5.92	positive regulation of endothelial tube morphogenesis	biological process	GO:1905956	1	1	18204	49	ITGAX
2.692e-03	-5.92	regulation of cell diameter	biological process	GO:0060305	1	1	18204	49	PLEK
2.692e-03	-5.92	protein secretion by platelet	biological process	GO:0070560	1	1	18204	49	PLEK
2.692e-03	-5.92	macrophage migration inhibitory factor signaling pathway	biological process	GO:0035691	1	1	18204	49	CD74
2.692e-03	-5.92	ARF protein signal transduction	biological process	GO:0032011	1	1	18204	49	MYO9B
2.692e-03	-5.92	regulation of inositol-polyphosphate 5-phosphatase activity	biological process	GO:0010924	1	1	18204	49	PLEK
2.692e-03	-5.92	positive regulation of inositol-polyphosphate 5-phosphatase activity	biological process	GO:0010925	1	1	18204	49	PLEK
2.697e-03	-5.92	p47_phox_C	pfam domains	PF08944	1	1	17795	48	NCF1
2.697e-03	-5.92	MHC2-interact	pfam domains	PF09307	1	1	17795	48	CD74
2.697e-03	-5.92	Propeptide_C1	pfam domains	PF08127	1	1	17795	48	CTSB
2.697e-03	-5.92	NCF1_PBR_AIR	pfam domains	PF16621	1	1	17795	48	NCF1
2.697e-03	-5.92	MHCassoc_trimer	pfam domains	PF08831	1	1	17795	48	CD74
2.697e-03	-5.92	mit_SMPDase	pfam domains	PF14724	1	1	17795	48	SMPD4
2.697e-03	-5.92	WW_FCH_linker	pfam domains	PF16623	1	1	17795	48	GAS7
2.697e-03	-5.92	GTP_cyclohydroI	pfam domains	PF01227	1	1	17795	48	GCH1
2.697e-03	-5.92	Complex1_49kDa	pfam domains	PF00346	1	1	17795	48	NDUFS2
2.698e-03	-5.92	SLC39A14 (solute carrier family 39 member 14)	protein interactions	23516	108	3	19454	50	RAC2,UNC93B1,P2RY6
2.700e-03	-5.91	NCF1_PBR/AIR	interpro domains	IPR032136	1	1	18521	50	NCF1
2.700e-03	-5.91	NCF1_C	interpro domains	IPR015039	1	1	18521	50	NCF1
2.700e-03	-5.91	Plexin-D1_Sema	interpro domains	IPR042719	1	1	18521	50	PLXND1
2.700e-03	-5.91	Integrin_b-2_sf	interpro domains	IPR015439	1	1	18521	50	ITGB2
2.700e-03	-5.91	NCF1_SH3_1	interpro domains	IPR035756	1	1	18521	50	NCF1
2.700e-03	-5.91	CD74_antigen	interpro domains	IPR043530	1	1	18521	50	CD74
2.700e-03	-5.91	GTP_CycHdrlase_I_dom	interpro domains	IPR020602	1	1	18521	50	GCH1
2.700e-03	-5.91	MHC_II-assoc_invar_chain	interpro domains	IPR022339	1	1	18521	50	CD74
2.700e-03	-5.91	RBM47_RRM3	interpro domains	IPR034445	1	1	18521	50	RBM47
2.700e-03	-5.91	RBM47_RRM1	interpro domains	IPR047044	1	1	18521	50	RBM47
2.700e-03	-5.91	GTP-CH-I_C/QueF	interpro domains	IPR043133	1	1	18521	50	GCH1
2.700e-03	-5.91	MHC_II-assoc_invariant_trimer	interpro domains	IPR011988	1	1	18521	50	CD74
2.700e-03	-5.91	NADH_UbQ_OxRdtase_49kDa_CS	interpro domains	IPR014029	1	1	18521	50	NDUFS2
2.700e-03	-5.91	GTP_CycHdrlase_I_CS	interpro domains	IPR018234	1	1	18521	50	GCH1
2.700e-03	-5.91	PX_p47phox	interpro domains	IPR034909	1	1	18521	50	NCF1
2.700e-03	-5.91	NDH1_su_D/H	interpro domains	IPR022885	1	1	18521	50	NDUFS2
2.700e-03	-5.91	PLEK_DEP	interpro domains	IPR037371	1	1	18521	50	PLEK
2.700e-03	-5.91	M14_CPN	interpro domains	IPR033814	1	1	18521	50	CPN1
2.700e-03	-5.91	bHLHzip_TFEB	interpro domains	IPR024098	1	1	18521	50	TFEB
2.700e-03	-5.91	Sphingomy_SMPD4	interpro domains	IPR024129	1	1	18521	50	SMPD4
2.700e-03	-5.91	CSF-1_receptor	interpro domains	IPR030658	1	1	18521	50	CSF1R
2.700e-03	-5.91	MHCII_invariant_trimer_sf	interpro domains	IPR036613	1	1	18521	50	CD74
2.700e-03	-5.91	MHC_II-assoc_invar/CLIP_MHC-bd	interpro domains	IPR015386	1	1	18521	50	CD74
2.700e-03	-5.91	GTP-CH-I_N	interpro domains	IPR043134	1	1	18521	50	GCH1
2.700e-03	-5.91	RhoGAP_myosin_IXB	interpro domains	IPR028557	1	1	18521	50	MYO9B
2.700e-03	-5.91	DAPP1_SH2	interpro domains	IPR035843	1	1	18521	50	DAPP1
2.700e-03	-5.91	LRMDA	interpro domains	IPR043313	1	1	18521	50	LRMDA
2.700e-03	-5.91	SH2B3_SH2	interpro domains	IPR035059	1	1	18521	50	SH2B3
2.700e-03	-5.91	NiFe-Hase_large	interpro domains	IPR029014	1	1	18521	50	NDUFS2
2.700e-03	-5.91	P2Y6_rcpt	interpro domains	IPR001973	1	1	18521	50	P2RY6
2.700e-03	-5.91	Propeptide_C1A	interpro domains	IPR012599	1	1	18521	50	CTSB
2.700e-03	-5.91	NCF1_SH3_2	interpro domains	IPR035757	1	1	18521	50	NCF1
2.700e-03	-5.91	UNC93B1	interpro domains	IPR043268	1	1	18521	50	UNC93B1
2.700e-03	-5.91	RA_Myosin-IXb	interpro domains	IPR046989	1	1	18521	50	MYO9B
2.700e-03	-5.91	NADH_Q_OxRdtase_suD	interpro domains	IPR001135	1	1	18521	50	NDUFS2
2.700e-03	-5.91	P47PHOX	interpro domains	IPR001655	1	1	18521	50	NCF1
2.700e-03	-5.91	RBM47_RRM2	interpro domains	IPR034440	1	1	18521	50	RBM47
2.700e-03	-5.91	GTP_CycHdrlase_I	interpro domains	IPR001474	1	1	18521	50	GCH1
2.700e-03	-5.91	GAS7_F-BAR	interpro domains	IPR037957	1	1	18521	50	GAS7
2.700e-03	-5.91	ABR_PH	interpro domains	IPR037865	1	1	18521	50	ABR
2.700e-03	-5.91	HCK_SH2	interpro domains	IPR035851	1	1	18521	50	HCK
2.700e-03	-5.91	FYB_hSH3	interpro domains	IPR035540	1	1	18521	50	FYB1
2.743e-03	-5.90	integrin complex	cellular component	GO:0008305	31	2	19108	48	ITGAX,ITGB2
2.751e-03	-5.90	Class I PI3K signaling events	Pathway Interaction DB	pi3kcipathway	41	3	2226	16	HCK,DAPP1,PREX1
2.775e-03	-5.89	TNPO3 (transportin 3)	protein interactions	23534	228	4	19454	50	MFNG,GCH1,P2RY6,UNC93B1
2.795e-03	-5.88	regulation of intracellular signal transduction	biological process	GO:1902531	1832	12	18204	49	ARHGAP15,CSF1R,MARCO,CD74,NCF1,P2RY6,SH2B3,NCKAP1L,PLEK,PREX1,MYO9B,ABR
2.804e-03	-5.88	ntegrin, alpha v. Chain A, domain 3	gene3d domains	2.60.40.1510	26	2	14470	44	ITGAX,ITGB2
2.834e-03	-5.87	positive regulation of myeloid cell differentiation	biological process	GO:0045639	105	3	18204	49	NCKAP1L,CD74,ZFP36L1
2.834e-03	-5.87	response to type II interferon	biological process	GO:0034341	105	3	18204	49	CD74,GCH1,HCK
2.842e-03	-5.86	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	3	19454	50	CSF1R,HCK,SH2B3
2.874e-03	-5.85	regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050730	220	4	18204	49	ITGB2,NCF1,CD74,CSF1R
2.882e-03	-5.85	mononuclear cell differentiation	biological process	GO:1903131	364	5	18204	49	CD74,CSF1R,PREX1,MFNG,ZFP36L1
2.925e-03	-5.83	SH3_1	pfam domains	PF00018	106	3	17795	48	NCF1,HCK,MYO1F
2.942e-03	-5.83	plasma membrane raft	cellular component	GO:0044853	114	3	19108	48	HCK,ENTPD1,ITGB2
2.942e-03	-5.83	regulation of superoxide metabolic process	biological process	GO:0090322	30	2	18204	49	GCH1,ITGB2
2.954e-03	-5.82	HLA-B (major histocompatibility complex, class I, B)	protein interactions	3106	232	4	19454	50	RAC2,SMPD4,ITM2B,WDFY3
2.968e-03	-5.82	organelle membrane	cellular component	GO:0031090	3742	18	19108	48	NDUFS2,UNC93B1,CD68,GCH1,ZNRF2,ITGAX,RAC2,ITGB2,CD74,NCKAP1L,MFNG,WDFY3,SMPD4,CMTM6,QSOX1,ITM2B,TFEB,MARCO
2.985e-03	-5.81	locomotion	biological process	GO:0040011	367	5	18204	49	PREX1,GAB1,RAC2,NCKAP1L,ITGB2
2.993e-03	-5.81	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	8	19454	50	TFEB,NCAM2,P2RY6,ITGB2,GAB1,ZFP36L1,CD74,RAPGEF6
3.041e-03	-5.80	-	gene3d domains	1.10.286.10	1	1	14470	44	GCH1
3.041e-03	-5.80	Cytochrome-c3 Hydrogenase, chain B	gene3d domains	1.10.645.10	1	1	14470	44	NDUFS2
3.041e-03	-5.80	MHC class II-associated invariant chain, trimerisation domain	gene3d domains	1.10.870.10	1	1	14470	44	CD74
3.041e-03	-5.80	-	gene3d domains	6.20.50.10	1	1	14470	44	ITGB2
3.041e-03	-5.80	-	gene3d domains	3.30.1130.10	1	1	14470	44	GCH1
3.057e-03	-5.79	RASA3 (RAS p21 protein activator 3)	protein interactions	22821	32	2	19454	50	HCK,RAC2
3.095e-03	-5.78	guanyl-nucleotide exchange factor activity	molecular function	GO:0005085	228	4	18094	48	ABR,ELMO1,RAPGEF6,PREX1
3.140e-03	-5.76	antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	GO:0019886	31	2	18204	49	CD74,UNC93B1
3.144e-03	-5.76	ATP5MF (ATP synthase membrane subunit f)	protein interactions	9551	114	3	19454	50	P2RY6,UNC93B1,LPP
3.179e-03	-5.75	SH2	interpro domains	IPR000980	109	3	18521	50	DAPP1,HCK,SH2B3
3.180e-03	-5.75	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	11	16828	46	RBM47,P2RY6,ITGAX,NCF1,CSF1R,ITGB2,MYO1F,NCAM2,ELMO1,PREX1,SLCO2B1
3.249e-03	-5.73	HS6ST1 (heparan sulfate 6-O-sulfotransferase 1)	protein interactions	9394	33	2	19454	50	ITM2B,MFNG
3.249e-03	-5.73	ELMO3 (engulfment and cell motility 3)	protein interactions	79767	33	2	19454	50	ELMO1,RAC2
3.252e-03	-5.73	P2Y6PRNOCPTR	prints domains	PR01068	1	1	5227	17	P2RY6
3.252e-03	-5.73	P47PHOX	prints domains	PR00498	1	1	5227	17	NCF1
3.252e-03	-5.73	CD74ANTIGEN	prints domains	PR01990	1	1	5227	17	CD74
3.270e-03	-5.72	developmental process	biological process	GO:0032502	5716	25	18204	49	CTSB,NCAM2,ZFP36L1,LRMDA,PLXND1,GAS7,SH2B3,NDUFS2,ITGAX,MYO9B,RAPGEF6,TFEB,MFNG,PLEK,UNC93B1,RBM47,HCK,PREX1,GAB1,CD74,CSF1R,RAC2,NCKAP1L,ITGB2,ITM2B
3.286e-03	-5.72	RCN1 (reticulocalbin 1)	protein interactions	5954	239	4	19454	50	MYO9B,CTSB,CD74,P2RY6
3.302e-03	-5.71	THEM6 (thioesterase superfamily member 6)	protein interactions	51337	116	3	19454	50	UNC93B1,P2RY6,RAC2
3.381e-03	-5.69	scalp	COSMIC cancer mutations	scalp	2110	13	16828	46	SLCO2B1,ITGB2,MYO1F,CSF1R,NCKAP1L,ELMO1,NCAM2,P2RY6,MARCO,RBM47,PREX1,NCF1,ITGAX
3.400e-03	-5.68	erythrocyte homeostasis	biological process	GO:0034101	112	3	18204	49	SH2B3,NCKAP1L,RAC2
3.423e-03	-5.68	regulation of leukocyte migration	biological process	GO:0002685	231	4	18204	49	CSF1R,CD74,RAC2,NCKAP1L
3.436e-03	-5.67	STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B)	protein interactions	201595	242	4	19454	50	RAC2,CTSB,UNC93B1,P2RY6
3.447e-03	-5.67	regulation of immune response	biological process	GO:0050776	944	8	18204	49	CD74,FYB1,NCF1,ITGB2,NCKAP1L,UNC93B1,HCK,RBM47
3.465e-03	-5.67	GID8 (GID complex subunit 8 homolog)	protein interactions	54994	118	3	19454	50	PREX1,GCH1,CTSB
3.481e-03	-5.66	oxidoreductase complex	cellular component	GO:1990204	121	3	19108	48	RAC2,NCF1,NDUFS2
3.486e-03	-5.66	regulation of regulated secretory pathway	biological process	GO:1903305	113	3	18204	49	NCKAP1L,ITGB2,RAC2
3.519e-03	-5.65	SH2_dom_sf	interpro domains	IPR036860	113	3	18521	50	HCK,DAPP1,SH2B3
3.525e-03	-5.65	receptor complex	cellular component	GO:0043235	409	5	19108	48	PLXND1,ITGAX,CSF1R,CD74,ITGB2
3.548e-03	-5.64	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	3	19454	50	CD74,MYO9B,QSOX1
3.553e-03	-5.64	antigen processing and presentation of peptide antigen via MHC class II	biological process	GO:0002495	33	2	18204	49	CD74,UNC93B1
3.600e-03	-5.63	cytosol	cellular component	GO:0005829	5475	23	19108	48	DAPP1,PLEK,ZNRF2,GCH1,LPP,MYO9B,TFEB,NCKAP1L,HCK,ARHGAP15,ZFP36L1,RAC2,MYO1F,ELMO1,ABR,NCF1,NOL4L,WDFY3,PREX1,RAPGEF6,SH2B3,GAB1,FYB1
3.611e-03	-5.62	COMPLEX1_49K	prosite domains	PS00535	1	1	12186	44	NDUFS2
3.611e-03	-5.62	GTP_CYCLOHYDROL_1_2	prosite domains	PS00860	1	1	12186	44	GCH1
3.611e-03	-5.62	GTP_CYCLOHYDROL_1_1	prosite domains	PS00859	1	1	12186	44	GCH1
3.623e-03	-5.62	regulation of actin filament-based process	biological process	GO:0032970	384	5	18204	49	NCKAP1L,PLEK,HCK,PREX1,CSF1R
3.632e-03	-5.62	PJA1 (praja ring finger ubiquitin ligase 1)	protein interactions	64219	120	3	19454	50	ENTPD1,MYO9B,ABR
3.649e-03	-5.61	GAS7 (growth arrest specific 7)	protein interactions	8522	35	2	19454	50	NCKAP1L,GAS7
3.649e-03	-5.61	C5 (complement C5)	protein interactions	727	35	2	19454	50	CPN1,CTSB
3.649e-03	-5.61	Mbp (myelin basic protein)	protein interactions	17196	35	2	19454	50	FYB1,HCK
3.649e-03	-5.61	JAG1 (jagged canonical Notch ligand 1)	protein interactions	182	35	2	19454	50	MFNG,RAC2
3.740e-03	-5.59	vesicle	cellular component	GO:0031982	4141	19	19108	48	RAPGEF6,HCK,NCKAP1L,CD74,ITGB2,MARCO,ITM2B,NCF1,RGS19,CMTM6,QSOX1,CTSB,CD68,GCH1,ENTPD1,UNC93B1,RAC2,ITGAX,ZNRF2
3.749e-03	-5.59	MET (MET proto-oncogene, receptor tyrosine kinase)	protein interactions	4233	248	4	19454	50	ITM2B,SH2B3,GAB1,HCK
3.769e-03	-5.58	regulation of B cell differentiation	biological process	GO:0045577	34	2	18204	49	ZFP36L1,NCKAP1L
3.769e-03	-5.58	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	biological process	GO:0002504	34	2	18204	49	UNC93B1,CD74
3.783e-03	-5.58	RA	pfam domains	PF00788	34	2	17795	48	RAPGEF6,MYO9B
3.794e-03	-5.57	breast-carcinoma-ER-PR-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-ER-PR-positive_carcinoma	1881	12	16828	46	CSF1R,ELMO1,GAB1,TFEB,MFNG,RAPGEF6,P2RY6,LPP,GAS7,ITGAX,RAC2,ZNRF2
3.794e-03	-5.57	ER-PR-positive_carcinoma	COSMIC cancer mutations	ER-PR-positive_carcinoma	1881	12	16828	46	RAPGEF6,P2RY6,MFNG,CSF1R,TFEB,ELMO1,GAB1,ITGAX,ZNRF2,RAC2,GAS7,LPP
3.869e-03	-5.55	regulation of immune effector process	biological process	GO:0002697	390	5	18204	49	ITGB2,NCKAP1L,RAC2,NCF1,CD74
4.049e-03	-5.51	Fc gamma R-mediated phagocytosis	KEGG pathways	hsa04666	90	3	7161	26	NCF1,HCK,RAC2
4.049e-03	-5.51	Fc gamma R-mediated phagocytosis	KEGG pathways	ko04666	90	3	7161	26	RAC2,HCK,NCF1
4.083e-03	-5.50	lung-carcinoma-undifferentiated_carcinoma	COSMIC cancer mutations	lung-carcinoma-undifferentiated_carcinoma	1408	10	16828	46	LPP,MFNG,TFEB,GAB1,CSF1R,ZNRF2,RAC2,P2RY6,RAPGEF6,GAS7
4.200e-03	-5.47	nef (Nef)	protein interactions	156110	802	7	19454	50	TFEB,CSF1R,RAC2,HCK,CD74,ITGAX,ELMO1
4.220e-03	-5.47	leukocyte migration	biological process	GO:0050900	245	4	18204	49	ITGB2,NCKAP1L,HCK,PREX1
4.295e-03	-5.45	undifferentiated_carcinoma	COSMIC cancer mutations	undifferentiated_carcinoma	1418	10	16828	46	RAPGEF6,P2RY6,ZNRF2,RAC2,GAS7,LPP,MFNG,TFEB,GAB1,CSF1R
4.314e-03	-5.45	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	4	19454	50	SH2B3,GAB1,HCK,DAPP1
4.326e-03	-5.44	microfilament motor activity	molecular function	GO:0000146	37	2	18094	48	MYO9B,MYO1F
4.352e-03	-5.44	BTK (Bruton tyrosine kinase)	protein interactions	695	128	3	19454	50	GAB1,DAPP1,HCK
4.429e-03	-5.42	G alpha (12/13) signalling events	REACTOME pathways	R-HSA-416482	88	3	10285	39	RAC2,PREX1,ABR
4.429e-03	-5.42	Focal Adhesion	WikiPathways	WP306	195	4	5310	19	HCK,ITGB2,RAC2,ITGAX
4.451e-03	-5.41	response to lipoprotein particle	biological process	GO:0055094	37	2	18204	49	CD68,ITGB2
4.451e-03	-5.41	cellular response to low-density lipoprotein particle stimulus	biological process	GO:0071404	37	2	18204	49	CD68,ITGB2
4.545e-03	-5.39	YIPF5 (Yip1 domain family member 5)	protein interactions	81555	130	3	19454	50	P2RY6,UNC93B1,RAC2
4.545e-03	-5.39	HM13 (histocompatibility minor 13)	protein interactions	81502	130	3	19454	50	CMTM6,UNC93B1,RAC2
4.547e-03	-5.39	amide binding	molecular function	GO:0033218	254	4	18094	48	ITGB2,CD74,MARCO,ITM2B
4.548e-03	-5.39	RA	smart domains	SM00314	29	2	9717	34	MYO9B,RAPGEF6
4.566e-03	-5.39	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	11	18204	49	GAB1,RBM47,ITGAX,ZFP36L1,GCH1,CSF1R,CD74,PLXND1,NCKAP1L,UNC93B1,PLEK
4.629e-03	-5.38	SH2 domain	gene3d domains	3.30.505.10	111	3	14470	44	SH2B3,HCK,DAPP1
4.645e-03	-5.37	human chr20q11.21	chromosome location	human chr20q11.21	53	2	26134	50	HCK,NOL4L
4.691e-03	-5.36	actin filament polymerization	biological process	GO:0030041	38	2	18204	49	GAS7,PREX1
4.691e-03	-5.36	heterotypic cell-cell adhesion	biological process	GO:0034113	38	2	18204	49	ITGAX,ITGB2
4.708e-03	-5.36	Myosin_head	pfam domains	PF00063	38	2	17795	48	MYO1F,MYO9B
4.719e-03	-5.36	Myosin_head_motor_dom	interpro domains	IPR001609	38	2	18521	50	MYO1F,MYO9B
4.742e-03	-5.35	OSBPL8 (oxysterol binding protein like 8)	protein interactions	114882	265	4	19454	50	P2RY6,UNC93B1,CD74,RAC2
4.766e-03	-5.35	B Cell Receptor Signaling Pathway	WikiPathways	WP23	98	3	5310	19	RAC2,GAB1,DAPP1
4.805e-03	-5.34	peptide binding	molecular function	GO:0042277	258	4	18094	48	CD74,ITGB2,MARCO,ITM2B
4.805e-03	-5.34	COPB1 (COPI coat complex subunit beta 1)	protein interactions	1315	266	4	19454	50	NCF1,CD74,UNC93B1,P2RY6
4.834e-03	-5.33	enzyme activator activity	molecular function	GO:0008047	599	6	18094	48	ABR,ARHGAP15,PREX1,MYO9B,NCKAP1L,NCF1
4.839e-03	-5.33	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	10	16828	46	GAS7,PLEK,SPOCK3,ENTPD1,RAPGEF6,ELMO1,GCH1,SMPD4,WDFY3,HCK
4.942e-03	-5.31	regulation of B cell activation	biological process	GO:0050864	128	3	18204	49	CD74,ZFP36L1,NCKAP1L
4.966e-03	-5.31	RA_dom	interpro domains	IPR000159	39	2	18521	50	RAPGEF6,MYO9B
4.980e-03	-5.30	ATP8 (ATP synthase F0 subunit 8)	protein interactions	4509	41	2	19454	50	P2RY6,UNC93B1
5.018e-03	-5.29	macrophage migration inhibitory factor receptor complex	cellular component	GO:0035692	2	1	19108	48	CD74
5.018e-03	-5.29	integrin alphaL-beta2 complex	cellular component	GO:0034687	2	1	19108	48	ITGB2
5.018e-03	-5.29	integrin alphaM-beta2 complex	cellular component	GO:0034688	2	1	19108	48	ITGB2
5.018e-03	-5.29	CSF1-CSF1R complex	cellular component	GO:1990682	2	1	19108	48	CSF1R
5.049e-03	-5.29	SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase)	protein interactions	6400	135	3	19454	50	P2RY6,UNC93B1,CTSB
5.083e-03	-5.28	lytic vacuole membrane	cellular component	GO:0098852	446	5	19108	48	TFEB,CD68,CMTM6,CD74,ZNRF2
5.083e-03	-5.28	lysosomal membrane	cellular component	GO:0005765	446	5	19108	48	TFEB,CMTM6,CD68,CD74,ZNRF2
5.094e-03	-5.28	cell projection	cellular component	GO:0042995	2398	13	19108	48	HCK,PREX1,WDFY3,NCAM2,PLXND1,NCF1,MYO9B,ABR,GCH1,PLEK,ZNRF2,RAC2,MYO1F
5.104e-03	-5.28	cellular response to organic substance	biological process	GO:0071310	1716	11	18204	49	CSF1R,CD74,NCF1,SMPD4,CD68,GAB1,ZFP36L1,SH2B3,P2RY6,CTSB,HCK
5.134e-03	-5.27	SYNGR4 (synaptogyrin 4)	protein interactions	23546	2	1	19454	50	GULP1
5.187e-03	-5.26	cellular response to lipoprotein particle stimulus	biological process	GO:0071402	40	2	18204	49	ITGB2,CD68
5.204e-03	-5.26	leukocyte activation	biological process	GO:0045321	599	6	18204	49	ZFP36L1,MFNG,CD74,ITGB2,TNFAIP8L2,PREX1
5.220e-03	-5.26	NFE2L1 (NFE2 like bZIP transcription factor 1)	protein interactions	4779	42	2	19454	50	WDFY3,NCF1
5.220e-03	-5.26	DYNC2I1 (dynein 2 intermediate chain 1)	protein interactions	55112	42	2	19454	50	ENTPD1,WDFY3
5.259e-03	-5.25	C3 (complement C3)	protein interactions	718	137	3	19454	50	ITGAX,CPN1,ITGB2
5.299e-03	-5.24	macrophage colony-stimulating factor receptor activity	molecular function	GO:0005011	2	1	18094	48	CSF1R
5.299e-03	-5.24	G protein-coupled UDP receptor activity	molecular function	GO:0045029	2	1	18094	48	P2RY6
5.299e-03	-5.24	macrophage migration inhibitory factor binding	molecular function	GO:0035718	2	1	18094	48	CD74
5.332e-03	-5.23	The role of Nef in HIV-1 replication and disease pathogenesis	REACTOME pathways	R-HSA-164952	29	2	10285	39	ELMO1,HCK
5.337e-03	-5.23	phagocytic vesicle	cellular component	GO:0045335	141	3	19108	48	NCF1,RAC2,UNC93B1
5.366e-03	-5.23	ATP5MG (ATP synthase membrane subunit g)	protein interactions	10632	138	3	19454	50	RBM47,UNC93B1,P2RY6
5.376e-03	-5.23	regulation of prostaglandin-E synthase activity	biological process	GO:2000361	2	1	18204	49	ITGB2
5.376e-03	-5.23	dihydrobiopterin metabolic process	biological process	GO:0051066	2	1	18204	49	GCH1
5.376e-03	-5.23	positive regulation of prostaglandin-E synthase activity	biological process	GO:2000363	2	1	18204	49	ITGB2
5.376e-03	-5.23	negative regulation of inositol phosphate biosynthetic process	biological process	GO:0010920	2	1	18204	49	PLEK
5.376e-03	-5.23	negative regulation of dopamine metabolic process	biological process	GO:0045963	2	1	18204	49	ITGB2
5.376e-03	-5.23	positive regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000448	2	1	18204	49	CD74
5.376e-03	-5.23	synaptic target recognition	biological process	GO:0008039	2	1	18204	49	PLXND1
5.376e-03	-5.23	negative regulation of catecholamine metabolic process	biological process	GO:0045914	2	1	18204	49	ITGB2
5.376e-03	-5.23	negative regulation of Kit signaling pathway	biological process	GO:1900235	2	1	18204	49	SH2B3
5.376e-03	-5.23	regulation of Kit signaling pathway	biological process	GO:1900234	2	1	18204	49	SH2B3
5.388e-03	-5.22	QSOX_Trx1	pfam domains	PF18108	2	1	17795	48	QSOX1
5.388e-03	-5.22	FAD_SOX	pfam domains	PF18371	2	1	17795	48	QSOX1
5.388e-03	-5.22	Bcr-Abl_Oligo	pfam domains	PF09036	2	1	17795	48	ABR
5.388e-03	-5.22	Nckap1	pfam domains	PF09735	2	1	17795	48	NCKAP1L
5.388e-03	-5.22	Tis11B_N	pfam domains	PF04553	2	1	17795	48	ZFP36L1
5.392e-03	-5.22	Bcr-Abl_oncoprot_oligo_sf	interpro domains	IPR036481	2	1	18521	50	ABR
5.392e-03	-5.22	Sulfhydryl_oxidase	interpro domains	IPR039798	2	1	18521	50	QSOX1
5.392e-03	-5.22	Ie/If_SH3	interpro domains	IPR035507	2	1	18521	50	MYO1F
5.392e-03	-5.22	MYSc_Myo9	interpro domains	IPR036023	2	1	18521	50	MYO9B
5.392e-03	-5.22	QSOX_FAD-bd_dom	interpro domains	IPR040986	2	1	18521	50	QSOX1
5.392e-03	-5.22	Nck-associated_protein-1	interpro domains	IPR019137	2	1	18521	50	NCKAP1L
5.392e-03	-5.22	NOL4/NOL4L	interpro domains	IPR039788	2	1	18521	50	NOL4L
5.392e-03	-5.22	Pleckstrin	interpro domains	IPR037370	2	1	18521	50	PLEK
5.392e-03	-5.22	Abr/Bcr	interpro domains	IPR037769	2	1	18521	50	ABR
5.392e-03	-5.22	QSOX_Trx1	interpro domains	IPR041269	2	1	18521	50	QSOX1
5.392e-03	-5.22	QSOX_FAD-bd_sf	interpro domains	IPR042568	2	1	18521	50	QSOX1
5.392e-03	-5.22	Tis11B_N	interpro domains	IPR007635	2	1	18521	50	ZFP36L1
5.392e-03	-5.22	Neural_cell_adh	interpro domains	IPR009138	2	1	18521	50	NCAM2
5.392e-03	-5.22	Myo9	interpro domains	IPR046987	2	1	18521	50	MYO9B
5.392e-03	-5.22	Bcr-Abl_oncoprot_oligo	interpro domains	IPR015123	2	1	18521	50	ABR
5.443e-03	-5.21	antigen processing and presentation of exogenous peptide antigen	biological process	GO:0002478	41	2	18204	49	CD74,UNC93B1
5.443e-03	-5.21	cortical actin cytoskeleton organization	biological process	GO:0030866	41	2	18204	49	PLEK,NCKAP1L
5.443e-03	-5.21	cell adhesion mediated by integrin	biological process	GO:0033627	41	2	18204	49	ITGAX,ITGB2
5.453e-03	-5.21	SH2	smart domains	SM00252	103	3	9717	34	DAPP1,SH2B3,HCK
5.480e-03	-5.21	Integrin-mediated Cell Adhesion	WikiPathways	WP185	103	3	5310	19	RAC2,ITGB2,ITGAX
5.556e-03	-5.19	leukocyte differentiation	biological process	GO:0002521	425	5	18204	49	ZFP36L1,MFNG,PREX1,CSF1R,CD74
5.612e-03	-5.18	regulation of actin filament polymerization	biological process	GO:0030833	134	3	18204	49	NCKAP1L,PREX1,HCK
5.696e-03	-5.17	NCAPD3 (non-SMC condensin II complex subunit D3)	protein interactions	23310	141	3	19454	50	CD74,UNC93B1,P2RY6
5.696e-03	-5.17	WASF2 (WASP family member 2)	protein interactions	10163	141	3	19454	50	GAS7,NCKAP1L,RAC2
5.714e-03	-5.16	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	29	16828	46	GAS7,RAC2,ITGAX,ABR,GCH1,QSOX1,CTSB,SH2B3,MARCO,PLEK,WDFY3,ARHGAP15,CSF1R,NCKAP1L,TFEB,GAB1,NCAM2,MFNG,PLXND1,ZNRF2,CPN1,PREX1,CMTM6,ITGB2,MYO1F,ZFP36L1,ELMO1,GULP1,SLCO2B1
5.739e-03	-5.16	positive regulation of response to stimulus	biological process	GO:0048584	2266	13	18204	49	UNC93B1,NCKAP1L,ITGB2,CSF1R,MARCO,CD74,NCF1,RAC2,MFNG,P2RY6,FYB1,RBM47,HCK
5.740e-03	-5.16	PSI	interpro domains	IPR016201	42	2	18521	50	ITGB2,PLXND1
5.788e-03	-5.15	regulation of leukocyte proliferation	biological process	GO:0070663	268	4	18204	49	NCKAP1L,RAC2,CD74,CSF1R
5.864e-03	-5.14	regulation of actin filament organization	biological process	GO:0110053	269	4	18204	49	PLEK,NCKAP1L,PREX1,HCK
5.922e-03	-5.13	DCAF8 (DDB1 and CUL4 associated factor 8)	protein interactions	50717	143	3	19454	50	UNC93B1,P2RY6,MYO9B
5.922e-03	-5.13	ATP13A3 (ATPase 13A3)	protein interactions	79572	143	3	19454	50	RAC2,P2RY6,UNC93B1
5.926e-03	-5.13	-	gene3d domains	1.10.10.820	38	2	14470	44	MYO1F,MYO9B
5.926e-03	-5.13	-	gene3d domains	1.20.58.530	38	2	14470	44	MYO9B,MYO1F
5.926e-03	-5.13	Myosin VI head, motor domain, U50 subdomain	gene3d domains	1.20.120.720	38	2	14470	44	MYO9B,MYO1F
5.967e-03	-5.12	myeloid leukocyte migration	biological process	GO:0097529	137	3	18204	49	ITGB2,NCKAP1L,PREX1
5.973e-03	-5.12	SKAP2 (src kinase associated phosphoprotein 2)	protein interactions	8935	45	2	19454	50	FYB1,HCK
6.001e-03	-5.12	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	8	19454	50	ZNRF2,GAB1,ZFP36L1,RAPGEF6,LPP,P2RY6,TFEB,NCAM2
6.037e-03	-5.11	COPG2 (COPI coat complex subunit gamma 2)	protein interactions	26958	144	3	19454	50	CD74,UNC93B1,P2RY6
6.053e-03	-5.11	GPR182 (G protein-coupled receptor 182)	protein interactions	11318	454	5	19454	50	SMPD4,CMTM6,UNC93B1,WDFY3,MYO9B
6.073e-03	-5.10	Bcr-Abl oncoprotein oligomerisation domain	gene3d domains	4.10.280.30	2	1	14470	44	ABR
6.073e-03	-5.10	QSOX sulfhydryl oxidase domain	gene3d domains	1.20.120.1960	2	1	14470	44	QSOX1
6.104e-03	-5.10	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	41	16828	46	PREX1,NDUFS2,HCK,CMTM6,PLXND1,CPN1,ENTPD1,ZNRF2,NCF1,CD74,ZFP36L1,ELMO1,MYO1F,ITGB2,ITM2B,SLCO2B1,GULP1,RAPGEF6,TNFAIP8L2,QSOX1,GCH1,GAS7,ABR,RAC2,ITGAX,NCAM2,NCKAP1L,TFEB,GAB1,SMPD4,WDFY3,CSF1R,ARHGAP15,MFNG,RBM47,MYO9B,CTSB,SPOCK3,PLEK,MARCO,SH2B3
6.234e-03	-5.08	ANKRD44 (ankyrin repeat domain 44)	protein interactions	91526	46	2	19454	50	ENTPD1,ZNRF2
6.234e-03	-5.08	TM4SF18 (transmembrane 4 L six family member 18)	protein interactions	116441	46	2	19454	50	UNC93B1,ITGB2
6.335e-03	-5.06	myeloid cell homeostasis	biological process	GO:0002262	140	3	18204	49	RAC2,NCKAP1L,SH2B3
6.391e-03	-5.05	PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha)	protein interactions	8394	147	3	19454	50	GCH1,PREX1,RAC2
6.495e-03	-5.04	NCAMFAMILY	prints domains	PR01838	2	1	5227	17	NCAM2
6.527e-03	-5.03	superoxide metabolic process	biological process	GO:0006801	45	2	18204	49	PREX1,NCF1
6.527e-03	-5.03	positive regulation of B cell proliferation	biological process	GO:0030890	45	2	18204	49	NCKAP1L,CD74
6.532e-03	-5.03	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	26	16828	46	GAS7,ITGAX,RAC2,CTSB,MYO9B,P2RY6,MARCO,RGS19,SH2B3,SPOCK3,WDFY3,NCAM2,TFEB,NCKAP1L,PLXND1,NCF1,CPN1,PREX1,NDUFS2,RAPGEF6,TNFAIP8L2,ITGB2,MYO1F,ELMO1,SLCO2B1,ITM2B
6.534e-03	-5.03	MYOSINHEAVY	prints domains	PR00193	38	2	5227	17	MYO1F,MYO9B
6.581e-03	-5.02	Regulation of actin cytoskeleton	KEGG pathways	hsa04810	211	4	7161	26	RAC2,NCKAP1L,ITGB2,ITGAX
6.581e-03	-5.02	Regulation of actin cytoskeleton	KEGG pathways	ko04810	211	4	7161	26	ITGAX,NCKAP1L,RAC2,ITGB2
6.602e-03	-5.02	vesicle-mediated transport	biological process	GO:0016192	1283	9	18204	49	ELMO1,HCK,P2RY6,ITGB2,GULP1,MYO1F,CMTM6,PLEK,MARCO
6.620e-03	-5.02	response to cytokine	biological process	GO:0034097	834	7	18204	49	HCK,GCH1,CSF1R,CD74,ZFP36L1,SMPD4,SH2B3
6.624e-03	-5.02	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	5	19454	50	RAC2,GAS7,GULP1,GAB1,LRMDA
6.645e-03	-5.01	UTP and CTP dephosphorylation I	BIOCYC pathways	META_PWY-7185	3	1	902	2	ENTPD1
6.645e-03	-5.01	UTP and CTP dephosphorylation II	BIOCYC pathways	META_PWY-7177	3	1	902	2	ENTPD1
6.645e-03	-5.01	tetrahydrobiopterin de novo biosynthesis	BIOCYC pathways	HUMAN_PWY-5663	3	1	902	2	GCH1
6.645e-03	-5.01	tetrahydrobiopterin biosynthesis I	BIOCYC pathways	META_PWY-5663	3	1	902	2	GCH1
6.645e-03	-5.01	tetrahydrobiopterin biosynthesis II	BIOCYC pathways	META_PWY-5664	3	1	902	2	GCH1
6.696e-03	-5.01	Neurotrophic factor-mediated Trk receptor signaling	Pathway Interaction DB	trkrpathway	56	3	2226	16	RGS19,GAB1,ELMO1
6.713e-03	-5.00	SH2	prosite domains	PS50001	107	3	12186	44	HCK,SH2B3,DAPP1
6.726e-03	-5.00	secretory granule	cellular component	GO:0030141	897	7	19108	48	ITGB2,CTSB,NCKAP1L,ITGAX,CD68,CMTM6,QSOX1
6.748e-03	-5.00	intracellular signaling cassette	biological process	GO:0141124	837	7	18204	49	ABR,ELMO1,MYO9B,RAPGEF6,RGS19,RAC2,ZFP36L1
6.812e-03	-4.99	neuron recognition	biological process	GO:0008038	46	2	18204	49	PLXND1,NCAM2
6.840e-03	-4.98	nodular	COSMIC cancer mutations	nodular	1515	10	16828	46	RBM47,TNFAIP8L2,PLEK,SPOCK3,ITGB2,ARHGAP15,WDFY3,NCKAP1L,TFEB,SLCO2B1
6.881e-03	-4.98	IPO11 (importin 11)	protein interactions	51194	151	3	19454	50	UNC93B1,P2RY6,LPP
6.881e-03	-4.98	CYFIP2 (cytoplasmic FMR1 interacting protein 2)	protein interactions	26999	151	3	19454	50	GAS7,RAC2,NCKAP1L
6.890e-03	-4.98	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	12	16828	46	SLCO2B1,MFNG,LPP,WDFY3,CSF1R,GAB1,TFEB,ZNRF2,RAC2,RAPGEF6,P2RY6,GAS7
6.890e-03	-4.98	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	12	16828	46	RAPGEF6,P2RY6,GAB1,TFEB,WDFY3,CSF1R,SLCO2B1,MFNG,GAS7,RAC2,ZNRF2,LPP
6.982e-03	-4.96	Golgi membrane	cellular component	GO:0000139	683	6	19108	48	UNC93B1,CD74,MFNG,SMPD4,ITM2B,QSOX1
7.049e-03	-4.95	MCRIP1 (MAPK regulated corepressor interacting protein 1)	protein interactions	348262	49	2	19454	50	RBM47,P2RY6
7.049e-03	-4.95	GPR173 (G protein-coupled receptor 173)	protein interactions	54328	49	2	19454	50	UNC93B1,CMTM6
7.103e-03	-4.95	regulation of erythrocyte differentiation	biological process	GO:0045646	47	2	18204	49	NCKAP1L,ZFP36L1
7.147e-03	-4.94	UBR4 (ubiquitin protein ligase E3 component n-recognin 4)	protein interactions	23352	298	4	19454	50	UNC93B1,P2RY6,CD74,CTSB
7.147e-03	-4.94	GPR45 (G protein-coupled receptor 45)	protein interactions	11250	298	4	19454	50	WDFY3,SMPD4,CMTM6,NDUFS2
7.224e-03	-4.93	lipid binding	molecular function	GO:0008289	861	7	18094	48	WDFY3,HCK,DAPP1,NCF1,FYB1,RAPGEF6,PREX1
7.246e-03	-4.93	leukocyte chemotaxis	biological process	GO:0030595	147	3	18204	49	PREX1,NCKAP1L,ITGB2
7.330e-03	-4.92	DOK1 (docking protein 1)	protein interactions	1796	50	2	19454	50	HCK,ITGB2
7.382e-03	-4.91	regulation of reactive oxygen species metabolic process	biological process	GO:2000377	148	3	18204	49	RAC2,GCH1,ITGB2
7.443e-03	-4.90	Kazal_dom	interpro domains	IPR002350	48	2	18521	50	SLCO2B1,SPOCK3
7.564e-03	-4.88	specific granule	cellular component	GO:0042581	160	3	19108	48	ITGB2,CMTM6,QSOX1
7.569e-03	-4.88	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	26	16828	46	WDFY3,ARHGAP15,CSF1R,SMPD4,NCAM2,NCKAP1L,P2RY6,SH2B3,SPOCK3,CTSB,RBM47,MYO9B,GCH1,RAC2,ITGAX,ABR,GAS7,SLCO2B1,ITM2B,DAPP1,ITGB2,MYO1F,ELMO1,HCK,PREX1,PLXND1
7.569e-03	-4.88	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	26	16828	46	NCKAP1L,NCAM2,CSF1R,ARHGAP15,SMPD4,WDFY3,SPOCK3,SH2B3,P2RY6,MYO9B,RBM47,CTSB,GCH1,ABR,ITGAX,RAC2,GAS7,DAPP1,ITM2B,SLCO2B1,ELMO1,ITGB2,MYO1F,HCK,PREX1,PLXND1
7.615e-03	-4.88	lymphocyte differentiation	biological process	GO:0030098	290	4	18204	49	CD74,PREX1,MFNG,ZFP36L1
7.627e-03	-4.88	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	25	16828	46	RAPGEF6,ZFP36L1,ELMO1,MYO1F,DAPP1,SLCO2B1,PLXND1,CPN1,ENTPD1,NDUFS2,PREX1,HCK,MYO9B,MARCO,P2RY6,GAB1,NCKAP1L,WDFY3,CSF1R,ARHGAP15,MFNG,CD68,GAS7,ABR,ITGAX
7.658e-03	-4.87	placenta development	biological process	GO:0001890	150	3	18204	49	CTSB,TFEB,ZFP36L1
7.691e-03	-4.87	SRPX2 (sushi repeat containing protein X-linked 2)	protein interactions	27286	3	1	19454	50	CTSB
7.691e-03	-4.87	Sestd1 (SEC14 and spectrin domains 1)	protein interactions	228071	3	1	19454	50	LPP
7.700e-03	-4.87	platelet aggregation	biological process	GO:0070527	49	2	18204	49	ENTPD1,PLEK
7.721e-03	-4.86	MYSc	smart domains	SM00242	38	2	9717	34	MYO9B,MYO1F
7.825e-03	-4.85	Leukocyte transendothelial migration	KEGG pathways	hsa04670	114	3	7161	26	ITGB2,NCF1,RAC2
7.825e-03	-4.85	Leukocyte transendothelial migration	KEGG pathways	ko04670	114	3	7161	26	NCF1,ITGB2,RAC2
7.832e-03	-4.85	RA	prosite domains	PS50200	37	2	12186	44	RAPGEF6,MYO9B
7.885e-03	-4.84	response to lipid	biological process	GO:0033993	862	7	18204	49	HCK,ZFP36L1,CPN1,NCF1,GCH1,CD68,P2RY6
7.909e-03	-4.84	EVI5 (ecotropic viral integration site 5)	protein interactions	7813	52	2	19454	50	UNC93B1,P2RY6
7.909e-03	-4.84	ATP5F1E (ATP synthase F1 subunit epsilon)	protein interactions	514	52	2	19454	50	P2RY6,UNC93B1
7.928e-03	-4.84	STYK1 (serine/threonine/tyrosine kinase 1)	protein interactions	55359	159	3	19454	50	GAB1,MYO1F,SMPD4
7.928e-03	-4.84	COG6 (component of oligomeric golgi complex 6)	protein interactions	57511	159	3	19454	50	UNC93B1,P2RY6,CD68
7.938e-03	-4.84	ICAM-3 receptor activity	molecular function	GO:0030369	3	1	18094	48	ITGB2
7.938e-03	-4.84	G protein-coupled ADP receptor activity	molecular function	GO:0001621	3	1	18094	48	P2RY6
7.938e-03	-4.84	flavin-dependent sulfhydryl oxidase activity	molecular function	GO:0016971	3	1	18094	48	QSOX1
7.938e-03	-4.84	G protein-coupled UTP receptor activity	molecular function	GO:0045030	3	1	18094	48	P2RY6
7.938e-03	-4.84	apyrase activity	molecular function	GO:0004050	3	1	18094	48	ENTPD1
7.938e-03	-4.84	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	molecular function	GO:0033829	3	1	18094	48	MFNG
8.007e-03	-4.83	cortical cytoskeleton organization	biological process	GO:0030865	50	2	18204	49	NCKAP1L,PLEK
8.007e-03	-4.83	antigen processing and presentation of exogenous antigen	biological process	GO:0019884	50	2	18204	49	CD74,UNC93B1
8.054e-03	-4.82	monocyte homeostasis	biological process	GO:0035702	3	1	18204	49	SH2B3
8.054e-03	-4.82	negative regulation of cytotoxic T cell degranulation	biological process	GO:0043318	3	1	18204	49	NCKAP1L
8.054e-03	-4.82	septum transversum development	biological process	GO:0003343	3	1	18204	49	ZFP36L1
8.054e-03	-4.82	positive regulation of intracellular mRNA localization	biological process	GO:1904582	3	1	18204	49	ZFP36L1
8.054e-03	-4.82	regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000446	3	1	18204	49	CD74
8.054e-03	-4.82	leukocyte migration involved in immune response	biological process	GO:0002522	3	1	18204	49	HCK
8.054e-03	-4.82	cellular response to raffinose	biological process	GO:0097403	3	1	18204	49	ZFP36L1
8.054e-03	-4.82	regulation of cytotoxic T cell degranulation	biological process	GO:0043317	3	1	18204	49	NCKAP1L
8.054e-03	-4.82	response to raffinose	biological process	GO:1901545	3	1	18204	49	ZFP36L1
8.054e-03	-4.82	proepicardium development	biological process	GO:0003342	3	1	18204	49	ZFP36L1
8.071e-03	-4.82	MITF_TFEB_C_3_N	pfam domains	PF15951	3	1	17795	48	TFEB
8.071e-03	-4.82	ELMO_ARM	pfam domains	PF11841	3	1	17795	48	ELMO1
8.071e-03	-4.82	Phe_ZIP	pfam domains	PF08916	3	1	17795	48	SH2B3
8.071e-03	-4.82	hSH3	pfam domains	PF14603	3	1	17795	48	FYB1
8.071e-03	-4.82	ITGAX-like_Ig_3	pfam domains	PF21520	3	1	17795	48	ITGAX
8.071e-03	-4.82	Evr1_Alr	pfam domains	PF04777	3	1	17795	48	QSOX1
8.077e-03	-4.82	myeloid cell differentiation	biological process	GO:0030099	295	4	18204	49	CSF1R,RAC2,NCKAP1L,SH2B3
8.077e-03	-4.82	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	4	18204	49	P2RY6,CD74,MARCO,CSF1R
8.078e-03	-4.82	ELMO_ARM	interpro domains	IPR024574	3	1	18521	50	ELMO1
8.078e-03	-4.82	ZFP36-like	interpro domains	IPR045877	3	1	18521	50	ZFP36L1
8.078e-03	-4.82	ERV/ALR_sulphydryl_oxidase	interpro domains	IPR017905	3	1	18521	50	QSOX1
8.078e-03	-4.82	LAMP_CS	interpro domains	IPR018134	3	1	18521	50	CD68
8.078e-03	-4.82	Fringe	interpro domains	IPR017374	3	1	18521	50	MFNG
8.078e-03	-4.82	ITGAX-like_Ig_3	interpro domains	IPR048633	3	1	18521	50	ITGAX
8.078e-03	-4.82	ERV/ALR_sulphydryl_oxid_sf	interpro domains	IPR036774	3	1	18521	50	QSOX1
8.078e-03	-4.82	FYB1/2-like	interpro domains	IPR043443	3	1	18521	50	FYB1
8.078e-03	-4.82	SH2B	interpro domains	IPR030523	3	1	18521	50	SH2B3
8.078e-03	-4.82	ITM2	interpro domains	IPR040145	3	1	18521	50	ITM2B
8.078e-03	-4.82	hSH3	interpro domains	IPR029294	3	1	18521	50	FYB1
8.078e-03	-4.82	Phe_ZIP	interpro domains	IPR015012	3	1	18521	50	SH2B3
8.078e-03	-4.82	Phe_ZIP_sf	interpro domains	IPR036290	3	1	18521	50	SH2B3
8.078e-03	-4.82	MiT/TFE_N	interpro domains	IPR031867	3	1	18521	50	TFEB
8.129e-03	-4.81	positive regulation of hydrolase activity	biological process	GO:0051345	466	5	18204	49	PREX1,P2RY6,RAPGEF6,PLEK,ABR
8.206e-03	-4.80	ELMO2 (engulfment and cell motility 2)	protein interactions	63916	53	2	19454	50	ELMO1,RAC2
8.248e-03	-4.80	MYOSIN_MOTOR	prosite domains	PS51456	38	2	12186	44	MYO1F,MYO9B
8.320e-03	-4.79	regulation of protein tyrosine kinase activity	biological process	GO:0061097	51	2	18204	49	NCF1,CSF1R
8.390e-03	-4.78	regulation of biological quality	biological process	GO:0065008	2936	15	18204	49	PREX1,ARHGAP15,CSF1R,ITGB2,CMTM6,PLEK,NCKAP1L,HCK,CTSB,RBM47,ZFP36L1,ENTPD1,GCH1,SH2B3,PLXND1
8.461e-03	-4.77	anion binding	molecular function	GO:0043168	2412	13	18094	48	CSF1R,NCF1,RAPGEF6,HCK,DAPP1,RAC2,MYO1F,ENTPD1,MYO9B,QSOX1,ITM2B,PLEK,GCH1
8.484e-03	-4.77	DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12)	protein interactions	54788	163	3	19454	50	CD74,UNC93B1,P2RY6
8.484e-03	-4.77	GRAMD1A (GRAM domain containing 1A)	protein interactions	57655	163	3	19454	50	CD74,P2RY6,UNC93B1
8.507e-03	-4.77	LCP2 (lymphocyte cytosolic protein 2)	protein interactions	3937	54	2	19454	50	HCK,FYB1
8.638e-03	-4.75	positive regulation of actin filament polymerization	biological process	GO:0030838	52	2	18204	49	HCK,NCKAP1L
8.639e-03	-4.75	positive regulation of MAPK cascade	biological process	GO:0043410	473	5	18204	49	P2RY6,CSF1R,CD74,MARCO,NCF1
8.660e-03	-4.75	side of membrane	cellular component	GO:0098552	715	6	19108	48	CD74,ITGB2,HCK,NCF1,ITGAX,CTSB
8.729e-03	-4.74	myosin complex	cellular component	GO:0016459	56	2	19108	48	MYO9B,MYO1F
8.755e-03	-4.74	immune response-activating signaling pathway	biological process	GO:0002757	302	4	18204	49	HCK,FYB1,NCKAP1L,UNC93B1
8.771e-03	-4.74	RASA1 (RAS p21 protein activator 1)	protein interactions	5921	165	3	19454	50	GAB1,CSF1R,HCK
8.789e-03	-4.73	regulation of MAPK cascade	biological process	GO:0043408	669	6	18204	49	CD74,MARCO,NCF1,CSF1R,P2RY6,SH2B3
8.791e-03	-4.73	Hemostasis	REACTOME pathways	R-HSA-109582	632	7	10285	39	QSOX1,PLEK,ITGB2,RAC2,CD74,ITGAX,SH2B3
8.814e-03	-4.73	DOCK1 (dedicator of cytokinesis 1)	protein interactions	1793	55	2	19454	50	RAC2,ELMO1
8.843e-03	-4.73	LGALS1 (galectin 1)	protein interactions	3956	317	4	19454	50	PLXND1,CD68,RAC2,HCK
8.854e-03	-4.73	UTP and CTP dephosphorylation II	BIOCYC pathways	HUMAN_PWY-7177	4	1	902	2	ENTPD1
8.864e-03	-4.73	lymphocyte activation	biological process	GO:0046649	476	5	18204	49	TNFAIP8L2,PREX1,CD74,MFNG,ZFP36L1
8.917e-03	-4.72	TBL2 (transducin beta like 2)	protein interactions	26608	166	3	19454	50	RAC2,P2RY6,UNC93B1
8.917e-03	-4.72	CPD (carboxypeptidase D)	protein interactions	1362	166	3	19454	50	CPN1,CSF1R,RAC2
8.939e-03	-4.72	RHOT2 (ras homolog family member T2)	protein interactions	89941	318	4	19454	50	P2RY6,SMPD4,WDFY3,CD74
8.962e-03	-4.71	regulation of platelet activation	biological process	GO:0010543	53	2	18204	49	PLEK,SH2B3
9.032e-03	-4.71	protein complex involved in cell adhesion	cellular component	GO:0098636	57	2	19108	48	ITGB2,ITGAX
9.063e-03	-4.70	MACO1 (macoilin 1)	protein interactions	55219	167	3	19454	50	UNC93B1,P2RY6,RAC2
9.063e-03	-4.70	CIP2A (cellular inhibitor of PP2A)	protein interactions	57650	167	3	19454	50	MFNG,UNC93B1,P2RY6
9.095e-03	-4.70	ERV/ALR sulfhydryl oxidase domain	gene3d domains	1.20.120.310	3	1	14470	44	QSOX1
9.095e-03	-4.70	-	gene3d domains	6.10.250.810	3	1	14470	44	ELMO1
9.095e-03	-4.70	-	gene3d domains	6.10.140.110	3	1	14470	44	SH2B3
9.159e-03	-4.69	regulation of small GTPase mediated signal transduction	biological process	GO:0051056	306	4	18204	49	ABR,MYO9B,ARHGAP15,PREX1
9.177e-03	-4.69	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	18	16828	46	NDUFS2,QSOX1,CMTM6,GAS7,PLXND1,GAB1,NCKAP1L,ELMO1,NCAM2,ITGB2,WDFY3,ARHGAP15,CSF1R,SLCO2B1,MYO9B,SH2B3,MARCO,RAPGEF6
9.177e-03	-4.69	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	18	16828	46	QSOX1,NDUFS2,CMTM6,PLXND1,GAS7,CSF1R,WDFY3,ARHGAP15,ITGB2,NCAM2,GAB1,ELMO1,NCKAP1L,SLCO2B1,MYO9B,MARCO,RAPGEF6,SH2B3
9.212e-03	-4.69	KLK10 (kallikrein related peptidase 10)	protein interactions	5655	168	3	19454	50	RAC2,ITGB2,MYO1F
9.290e-03	-4.68	positive regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050731	161	3	18204	49	CSF1R,CD74,NCF1
9.290e-03	-4.68	regulation of alcohol biosynthetic process	biological process	GO:1902930	54	2	18204	49	P2RY6,PLEK
9.300e-03	-4.68	phospholipid binding	molecular function	GO:0005543	489	5	18094	48	PREX1,NCF1,RAPGEF6,DAPP1,WDFY3
9.361e-03	-4.67	NUP210 (nucleoporin 210)	protein interactions	23225	169	3	19454	50	UNC93B1,P2RY6,CTSB
9.374e-03	-4.67	PSI	smart domains	SM00423	42	2	9717	34	ITGB2,PLXND1
9.442e-03	-4.66	EVI5L (ecotropic viral integration site 5 like)	protein interactions	115704	57	2	19454	50	UNC93B1,P2RY6
9.442e-03	-4.66	KNG1 (kininogen 1)	protein interactions	3827	57	2	19454	50	ITGB2,CPN1
9.442e-03	-4.66	FXN (frataxin)	protein interactions	2395	57	2	19454	50	CTSB,DAPP1
9.442e-03	-4.66	ICAM2 (intercellular adhesion molecule 2)	protein interactions	3384	57	2	19454	50	ITGB2,ITM2B
9.513e-03	-4.66	PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)	protein interactions	5286	170	3	19454	50	P2RY6,RBM47,RAC2
9.513e-03	-4.66	BZW1 (basic leucine zipper and W2 domains 1)	protein interactions	9689	170	3	19454	50	PREX1,P2RY6,UNC93B1
9.544e-03	-4.65	regulation of anatomical structure morphogenesis	biological process	GO:0022603	894	7	18204	49	PLXND1,ITGAX,ITGB2,CSF1R,ARHGAP15,HCK,GAB1
9.575e-03	-4.65	negative regulation of cell adhesion	biological process	GO:0007162	310	4	18204	49	CD74,SH2B3,TNFAIP8L2,PLXND1
9.579e-03	-4.65	human chr11q13.4	chromosome location	human chr11q13.4	77	2	26134	50	SLCO2B1,P2RY6
9.652e-03	-4.64	azurophil granule membrane	cellular component	GO:0035577	59	2	19108	48	CMTM6,CD68
9.763e-03	-4.63	SELENOF (selenoprotein F)	protein interactions	9403	58	2	19454	50	P2RY6,UNC93B1
9.819e-03	-4.62	Adaptive Immune System	REACTOME pathways	R-HSA-1280218	810	8	10285	39	DAPP1,CTSB,ITGB2,GAB1,ZNRF2,FYB1,CD74,NCF1
9.964e-03	-4.61	leukocyte cell-cell adhesion	biological process	GO:0007159	56	2	18204	49	ITGB2,RAC2
1.004e-02	-4.60	IL-6 signaling pathway	WikiPathways	WP364	43	2	5310	19	HCK,GAB1
1.009e-02	-4.60	CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4)	protein interactions	26504	59	2	19454	50	UNC93B1,P2RY6
1.011e-02	-4.59	T cell activation	biological process	GO:0042110	315	4	18204	49	ZFP36L1,PREX1,CD74,TNFAIP8L2
1.024e-02	-4.58	Map6 (microtubule-associated protein 6)	protein interactions	29457	4	1	19454	50	PLXND1
1.024e-02	-4.58	UBC1 (E2 ubiquitin-conjugating protein UBC1)	protein interactions	851757	4	1	19454	50	ZNRF2
1.031e-02	-4.57	regulation of myeloid leukocyte mediated immunity	biological process	GO:0002886	57	2	18204	49	RAC2,ITGB2
1.035e-02	-4.57	SEC63 (SEC63 homolog, protein translocation regulator)	protein interactions	11231	332	4	19454	50	SMPD4,P2RY6,UNC93B1,RBM47
1.042e-02	-4.56	DOCK2 (dedicator of cytokinesis 2)	protein interactions	1794	60	2	19454	50	RAC2,ELMO1
1.057e-02	-4.55	stem cell factor receptor binding	molecular function	GO:0005173	4	1	18094	48	SH2B3
1.057e-02	-4.55	CDP phosphatase activity	molecular function	GO:0036384	4	1	18094	48	ENTPD1
1.057e-02	-4.55	IDP phosphatase activity	molecular function	GO:1990003	4	1	18094	48	ENTPD1
1.057e-02	-4.55	G protein-coupled pyrimidinergic nucleotide receptor activity	molecular function	GO:0071553	4	1	18094	48	P2RY6
1.064e-02	-4.54	regulation of anatomical structure size	biological process	GO:0090066	498	5	18204	49	NCKAP1L,PLEK,PREX1,GCH1,HCK
1.066e-02	-4.54	regulation of phosphatase activity	biological process	GO:0010921	58	2	18204	49	PLEK,NCKAP1L
1.072e-02	-4.54	macrophage colony-stimulating factor signaling pathway	biological process	GO:0038145	4	1	18204	49	CSF1R
1.072e-02	-4.54	regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032960	4	1	18204	49	P2RY6
1.072e-02	-4.54	erythrocyte enucleation	biological process	GO:0043131	4	1	18204	49	RAC2
1.072e-02	-4.54	negative regulation of mature B cell apoptotic process	biological process	GO:0002906	4	1	18204	49	CD74
1.072e-02	-4.54	positive regulation of TORC2 signaling	biological process	GO:1904515	4	1	18204	49	NCKAP1L
1.072e-02	-4.54	positive regulation of mast cell proliferation	biological process	GO:0070668	4	1	18204	49	RAC2
1.072e-02	-4.54	enucleate erythrocyte maturation	biological process	GO:0043354	4	1	18204	49	RAC2
1.072e-02	-4.54	mast cell proliferation	biological process	GO:0070662	4	1	18204	49	RAC2
1.072e-02	-4.54	respiratory burst after phagocytosis	biological process	GO:0045728	4	1	18204	49	HCK
1.072e-02	-4.54	positive regulation of neutrophil degranulation	biological process	GO:0043315	4	1	18204	49	ITGB2
1.072e-02	-4.54	regulation of mature B cell apoptotic process	biological process	GO:0002905	4	1	18204	49	CD74
1.072e-02	-4.54	enucleation	biological process	GO:0090601	4	1	18204	49	RAC2
1.072e-02	-4.54	regulation of intracellular mRNA localization	biological process	GO:1904580	4	1	18204	49	ZFP36L1
1.072e-02	-4.54	positive regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032962	4	1	18204	49	P2RY6
1.072e-02	-4.54	dichotomous subdivision of terminal units involved in salivary gland branching	biological process	GO:0060666	4	1	18204	49	PLXND1
1.072e-02	-4.54	negative regulation of dendritic cell antigen processing and presentation	biological process	GO:0002605	4	1	18204	49	CD68
1.072e-02	-4.54	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031587	4	1	18204	49	P2RY6
1.072e-02	-4.54	positive regulation of epidermal growth factor-activated receptor activity	biological process	GO:0045741	4	1	18204	49	NCF1
1.075e-02	-4.53	DUF758	pfam domains	PF05527	4	1	17795	48	TNFAIP8L2
1.075e-02	-4.53	DUF3371	pfam domains	PF11851	4	1	17795	48	TFEB
1.076e-02	-4.53	TNFAIP8-like	interpro domains	IPR008477	4	1	18521	50	TNFAIP8L2
1.076e-02	-4.53	Gab1-4-like	interpro domains	IPR046355	4	1	18521	50	GAB1
1.076e-02	-4.53	MiT/TFE_C	interpro domains	IPR021802	4	1	18521	50	TFEB
1.076e-02	-4.53	TNFAIP8_sf	interpro domains	IPR038355	4	1	18521	50	TNFAIP8L2
1.076e-02	-4.53	VPS8 (VPS8 subunit of CORVET complex)	protein interactions	23355	61	2	19454	50	UNC93B1,P2RY6
1.076e-02	-4.53	PTPN18 (protein tyrosine phosphatase non-receptor type 18)	protein interactions	26469	61	2	19454	50	CTSB,GAB1
1.079e-02	-4.53	ERV_ALR	prosite domains	PS51324	3	1	12186	44	QSOX1
1.079e-02	-4.53	LAMP_2	prosite domains	PS00311	3	1	12186	44	CD68
1.080e-02	-4.53	GTPase activity	molecular function	GO:0003924	326	4	18094	48	RGS19,ENTPD1,RAC2,GCH1
1.081e-02	-4.53	human chr22q13.1	chromosome location	human chr22q13.1	82	2	26134	50	RAC2,MFNG
1.082e-02	-4.53	regulation of cell-cell adhesion	biological process	GO:0022407	500	5	18204	49	CD74,ITGB2,SH2B3,NCKAP1L,TNFAIP8L2
1.089e-02	-4.52	haematopoietic_and_lymphoid_tissue-other-idiopathic_erythrocytosis	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-other-idiopathic_erythrocytosis	4	1	16828	46	SH2B3
1.089e-02	-4.52	idiopathic_erythrocytosis	COSMIC cancer mutations	idiopathic_erythrocytosis	4	1	16828	46	SH2B3
1.094e-02	-4.52	regulation of exocytosis	biological process	GO:0017157	171	3	18204	49	RAC2,ITGB2,NCKAP1L
1.094e-02	-4.52	NDUFAF4 (NADH:ubiquinone oxidoreductase complex assembly factor 4)	protein interactions	29078	179	3	19454	50	P2RY6,NDUFS2,UNC93B1
1.110e-02	-4.50	IL1R2 (interleukin 1 receptor type 2)	protein interactions	7850	62	2	19454	50	QSOX1,ITM2B
1.110e-02	-4.50	GCH1 (GTP cyclohydrolase 1)	protein interactions	2643	62	2	19454	50	GCH1,RGS19
1.110e-02	-4.50	SLC39A7 (solute carrier family 39 member 7)	protein interactions	7922	180	3	19454	50	RGS19,RAC2,P2RY6
1.110e-02	-4.50	CYFIP1 (cytoplasmic FMR1 interacting protein 1)	protein interactions	23191	180	3	19454	50	NCKAP1L,RAC2,GAS7
1.126e-02	-4.49	regulation of lymphocyte activation	biological process	GO:0051249	505	5	18204	49	CD74,RAC2,ZFP36L1,TNFAIP8L2,NCKAP1L
1.126e-02	-4.49	regulation of phosphate metabolic process	biological process	GO:0019220	1154	8	18204	49	NCF1,CD74,MARCO,CSF1R,P2RY6,ITGB2,PLEK,NCKAP1L
1.131e-02	-4.48	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	8	18204	49	CSF1R,NCF1,CD74,MARCO,PLEK,NCKAP1L,ITGB2,P2RY6
1.133e-02	-4.48	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	28	16828	46	ITM2B,GULP1,ELMO1,ZFP36L1,MYO1F,CPN1,ZNRF2,PLXND1,PREX1,PLEK,SPOCK3,SH2B3,MARCO,CTSB,MFNG,NCKAP1L,GAB1,NCAM2,ARHGAP15,CSF1R,WDFY3,SMPD4,ABR,ITGAX,RAC2,GAS7,GCH1,QSOX1
1.137e-02	-4.48	positive regulation of cytokine-mediated signaling pathway	biological process	GO:0001961	60	2	18204	49	CD74,RBM47
1.144e-02	-4.47	NOXA1 (NADPH oxidase activator 1)	protein interactions	10811	63	2	19454	50	NCF1,RAC2
1.144e-02	-4.47	RAB32 (RAB32, member RAS oncogene family)	protein interactions	10981	63	2	19454	50	RAC2,LRMDA
1.145e-02	-4.47	TOP3B (DNA topoisomerase III beta)	protein interactions	8940	1465	9	19454	50	ABR,MYO9B,RBM47,TFEB,WDFY3,RAPGEF6,SH2B3,PREX1,PLXND1
1.145e-02	-4.47	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	8	19454	50	RAPGEF6,GAB1,ZFP36L1,ZNRF2,NCAM2,TFEB,P2RY6,RAC2
1.161e-02	-4.46	HCK (HCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3055	183	3	19454	50	HCK,ELMO1,GAB1
1.164e-02	-4.45	regulation of interleukin-6 production	biological process	GO:0032675	175	3	18204	49	UNC93B1,NCKAP1L,CD74
1.164e-02	-4.45	positive regulation of supramolecular fiber organization	biological process	GO:1902905	175	3	18204	49	HCK,PLEK,NCKAP1L
1.164e-02	-4.45	ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)	protein interactions	476	533	5	19454	50	RAC2,ZNRF2,UNC93B1,P2RY6,NDUFS2
1.166e-02	-4.45	ion binding	molecular function	GO:0043167	6007	24	18094	48	GCH1,PLEK,ITGB2,ZNRF2,MYO9B,LPP,MYO1F,RAC2,DAPP1,SPOCK3,CPN1,NDUFS2,HCK,WDFY3,RAPGEF6,ITM2B,QSOX1,ITGAX,MFNG,ENTPD1,SMPD4,NCF1,CSF1R,ZFP36L1
1.166e-02	-4.45	DOPA-Responsive Dystonia	SMPDB pathways	SMP0000486	8	1	1369	2	GCH1
1.166e-02	-4.45	Hyperphenylalaninemia Due to DHPR-Deficiency	SMPDB pathways	SMP0000489	8	1	1369	2	GCH1
1.166e-02	-4.45	Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps)	SMPDB pathways	SMP0000488	8	1	1369	2	GCH1
1.166e-02	-4.45	Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency	SMPDB pathways	SMP0000487	8	1	1369	2	GCH1
1.166e-02	-4.45	Sepiapterin Reductase Deficiency	SMPDB pathways	SMP0000491	8	1	1369	2	GCH1
1.166e-02	-4.45	Pterine Biosynthesis	SMPDB pathways	SMP0000005	8	1	1369	2	GCH1
1.166e-02	-4.45	Segawa Syndrome	SMPDB pathways	SMP0000490	8	1	1369	2	GCH1
1.174e-02	-4.44	negative regulation of G protein-coupled receptor signaling pathway	biological process	GO:0045744	61	2	18204	49	PLEK,SH2B3
1.179e-02	-4.44	AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2)	protein interactions	10555	64	2	19454	50	UNC93B1,P2RY6
1.195e-02	-4.43	NPLOC4 (NPL4 homolog, ubiquitin recognition factor)	protein interactions	55666	185	3	19454	50	LPP,NDUFS2,P2RY6
1.211e-02	-4.41	Tumor necrosis factor alpha-induced protein 8-like	gene3d domains	1.20.1440.160	4	1	14470	44	TNFAIP8L2
1.211e-02	-4.41	positive regulation of myeloid leukocyte differentiation	biological process	GO:0002763	62	2	18204	49	ZFP36L1,CD74
1.215e-02	-4.41	COG5 (component of oligomeric golgi complex 5)	protein interactions	10466	65	2	19454	50	P2RY6,UNC93B1
1.226e-02	-4.40	HLA-C (major histocompatibility complex, class I, C)	protein interactions	3107	349	4	19454	50	ITM2B,QSOX1,CTSB,RAC2
1.238e-02	-4.39	EPHA2 (EPH receptor A2)	protein interactions	1969	350	4	19454	50	CSF1R,RAC2,HCK,GAB1
1.250e-02	-4.38	apolipoprotein B mRNA editing enzyme complex	cellular component	GO:0030895	5	1	19108	48	RBM47
1.250e-02	-4.38	endolysosome lumen	cellular component	GO:0036021	5	1	19108	48	CTSB
1.250e-02	-4.38	HLA-DRB3 (major histocompatibility complex, class II, DR beta 3)	protein interactions	3125	66	2	19454	50	ITM2B,CD74
1.274e-02	-4.36	ESYT2 (extended synaptotagmin 2)	protein interactions	57488	353	4	19454	50	SMPD4,UNC93B1,P2RY6,RAC2
1.275e-02	-4.36	regulation of cytoskeleton organization	biological process	GO:0051493	521	5	18204	49	NCKAP1L,PLEK,HCK,PREX1,CSF1R
1.279e-02	-4.36	SAMD8 (sterile alpha motif domain containing 8)	protein interactions	142891	5	1	19454	50	MFNG
1.279e-02	-4.36	CPN2 (carboxypeptidase N subunit 2)	protein interactions	1370	5	1	19454	50	CPN1
1.284e-02	-4.36	RMND1 (required for meiotic nuclear division 1 homolog)	protein interactions	55005	190	3	19454	50	MFNG,CTSB,NDUFS2
1.287e-02	-4.35	actin polymerization or depolymerization	biological process	GO:0008154	64	2	18204	49	PREX1,GAS7
1.287e-02	-4.35	regulation of B cell proliferation	biological process	GO:0030888	64	2	18204	49	CD74,NCKAP1L
1.293e-02	-4.35	T cell differentiation	biological process	GO:0030217	182	3	18204	49	PREX1,CD74,ZFP36L1
1.293e-02	-4.35	regulation of cytokine-mediated signaling pathway	biological process	GO:0001959	182	3	18204	49	RBM47,CD74,SH2B3
1.294e-02	-4.35	KAZAL_2	prosite domains	PS51465	48	2	12186	44	SLCO2B1,SPOCK3
1.295e-02	-4.35	LYSASSOCTDMP	prints domains	PR00336	4	1	5227	17	CD68
1.302e-02	-4.34	UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1)	protein interactions	56886	191	3	19454	50	CTSB,UNC93B1,P2RY6
1.311e-02	-4.33	DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1)	protein interactions	64215	356	4	19454	50	P2RY6,UNC93B1,SMPD4,RAC2
1.312e-02	-4.33	response to tumor necrosis factor	biological process	GO:0034612	183	3	18204	49	GCH1,SMPD4,ZFP36L1
1.320e-02	-4.33	cyclohydrolase activity	molecular function	GO:0019238	5	1	18094	48	GCH1
1.320e-02	-4.33	oxygen sensor activity	molecular function	GO:0019826	5	1	18094	48	NDUFS2
1.320e-02	-4.33	TORC2 complex binding	molecular function	GO:1904841	5	1	18094	48	NCKAP1L
1.320e-02	-4.33	UBE3C (ubiquitin protein ligase E3C)	protein interactions	9690	192	3	19454	50	P2RY6,UNC93B1,CD74
1.324e-02	-4.32	CA6 (carbonic anhydrase 6)	protein interactions	765	68	2	19454	50	MYO9B,QSOX1
1.324e-02	-4.32	GEMIN6 (gem nuclear organelle associated protein 6)	protein interactions	79833	68	2	19454	50	P2RY6,UNC93B1
1.325e-02	-4.32	T cell differentiation in thymus	biological process	GO:0033077	65	2	18204	49	ZFP36L1,CD74
1.327e-02	-4.32	response to stress	biological process	GO:0006950	3388	16	18204	49	ENTPD1,ZFP36L1,GCH1,HCK,CD68,ITGB2,PLEK,UNC93B1,TNFAIP8L2,MARCO,CD74,NCF1,TFEB,CSF1R,ITGAX,NDUFS2
1.328e-02	-4.32	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	9	19454	50	HCK,ABR,SMPD4,ITM2B,CTSB,ITGB2,GULP1,CD74,ITGAX
1.331e-02	-4.32	positive regulation of cytoskeleton organization	biological process	GO:0051495	184	3	18204	49	PLEK,NCKAP1L,HCK
1.335e-02	-4.32	PGRMC1 (progesterone receptor membrane component 1)	protein interactions	10857	358	4	19454	50	CD74,P2RY6,UNC93B1,ARHGAP15
1.339e-02	-4.31	LTN1 (listerin E3 ubiquitin protein ligase 1)	protein interactions	26046	193	3	19454	50	CD74,UNC93B1,P2RY6
1.339e-02	-4.31	toll-like receptor 7 signaling pathway	biological process	GO:0034154	5	1	18204	49	UNC93B1
1.339e-02	-4.31	Roundabout signaling pathway	biological process	GO:0035385	5	1	18204	49	MYO9B
1.339e-02	-4.31	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031585	5	1	18204	49	P2RY6
1.339e-02	-4.31	T cell antigen processing and presentation	biological process	GO:0002457	5	1	18204	49	UNC93B1
1.339e-02	-4.31	regulation of lung blood pressure	biological process	GO:0014916	5	1	18204	49	GCH1
1.339e-02	-4.31	positive regulation of CD8-positive, alpha-beta T cell differentiation	biological process	GO:0043378	5	1	18204	49	NCKAP1L
1.339e-02	-4.31	thrombopoietin-mediated signaling pathway	biological process	GO:0038163	5	1	18204	49	SH2B3
1.339e-02	-4.31	negative regulation of myosin-light-chain-phosphatase activity	biological process	GO:0035509	5	1	18204	49	NCKAP1L
1.339e-02	-4.31	lymphocyte aggregation	biological process	GO:0071593	5	1	18204	49	RAC2
1.342e-02	-4.31	Fringe	pfam domains	PF02434	5	1	17795	48	MFNG
1.342e-02	-4.31	PH_19	pfam domains	PF19057	5	1	17795	48	ABR
1.342e-02	-4.31	Lamp	pfam domains	PF01299	5	1	17795	48	CD68
1.343e-02	-4.31	Lysosome-assoc_membr_glycop	interpro domains	IPR002000	5	1	18521	50	CD68
1.343e-02	-4.31	Lamp2-like_luminal	interpro domains	IPR048528	5	1	18521	50	CD68
1.343e-02	-4.31	Fringe-like_glycosylTrfase	interpro domains	IPR003378	5	1	18521	50	MFNG
1.343e-02	-4.31	HnRNP_R/Q_splicing_fac	interpro domains	IPR006535	5	1	18521	50	RBM47
1.347e-02	-4.31	cellular response to cytokine stimulus	biological process	GO:0071345	734	6	18204	49	CSF1R,CD74,HCK,ZFP36L1,SMPD4,SH2B3
1.348e-02	-4.31	ST7 (suppression of tumorigenicity 7)	protein interactions	7982	359	4	19454	50	SMPD4,P2RY6,UNC93B1,CTSB
1.355e-02	-4.30	negative regulation of immune system process	biological process	GO:0002683	529	5	18204	49	HCK,CD74,CD68,NCKAP1L,TNFAIP8L2
1.357e-02	-4.30	ATP5PF (ATP synthase peripheral stalk subunit F6)	protein interactions	522	194	3	19454	50	P2RY6,UNC93B1,TFEB
1.361e-02	-4.30	EVL (Enah/Vasp-like)	protein interactions	51466	69	2	19454	50	FYB1,HCK
1.361e-02	-4.30	YIF1B (Yip1 interacting factor homolog B, membrane trafficking protein)	protein interactions	90522	69	2	19454	50	P2RY6,UNC93B1
1.364e-02	-4.29	peptidyl-tyrosine phosphorylation	biological process	GO:0018108	66	2	18204	49	CSF1R,HCK
1.364e-02	-4.29	homotypic cell-cell adhesion	biological process	GO:0034109	66	2	18204	49	PLEK,ENTPD1
1.373e-02	-4.29	DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)	protein interactions	1650	361	4	19454	50	P2RY6,UNC93B1,RAC2,CTSB
1.376e-02	-4.29	RPUSD3 (RNA pseudouridine synthase D3)	protein interactions	285367	195	3	19454	50	NDUFS2,RBM47,RAC2
1.376e-02	-4.29	SGPL1 (sphingosine-1-phosphate lyase 1)	protein interactions	8879	195	3	19454	50	P2RY6,UNC93B1,CD74
1.395e-02	-4.27	CALM2 (calmodulin 2)	protein interactions	805	196	3	19454	50	RAC2,CTSB,MYO9B
1.399e-02	-4.27	IL6ST (interleukin 6 cytokine family signal transducer)	protein interactions	3572	70	2	19454	50	HCK,RAC2
1.403e-02	-4.27	cell projection organization	biological process	GO:0030030	1200	8	18204	49	MYO9B,RAPGEF6,NCAM2,GAS7,NCKAP1L,PLEK,RAC2,CSF1R
1.404e-02	-4.27	positive regulation of response to cytokine stimulus	biological process	GO:0060760	67	2	18204	49	CD74,RBM47
1.406e-02	-4.26	cellular response to lipid	biological process	GO:0071396	534	5	18204	49	CD68,P2RY6,NCF1,ZFP36L1,HCK
1.412e-02	-4.26	YES1 (YES proto-oncogene 1, Src family tyrosine kinase)	protein interactions	7525	364	4	19454	50	CSF1R,RAC2,HCK,GAB1
1.414e-02	-4.26	TMEM237 (transmembrane protein 237)	protein interactions	65062	197	3	19454	50	RAC2,UNC93B1,CMTM6
1.414e-02	-4.26	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	3	19454	50	HCK,WDFY3,GAB1
1.421e-02	-4.25	regulation of multicellular organismal process	biological process	GO:0051239	3113	15	18204	49	TNFAIP8L2,NCKAP1L,PLEK,UNC93B1,CSF1R,CD74,NCF1,RAC2,ITGAX,GAB1,PLXND1,SH2B3,GCH1,ZFP36L1,RBM47
1.425e-02	-4.25	regulation of signal transduction	biological process	GO:0009966	3114	15	18204	49	RBM47,RGS19,SH2B3,P2RY6,PREX1,MYO9B,ABR,MFNG,ARHGAP15,CSF1R,CD74,NCF1,MARCO,PLEK,NCKAP1L
1.433e-02	-4.25	NDC1 (NDC1 transmembrane nucleoporin)	protein interactions	55706	198	3	19454	50	UNC93B1,P2RY6,RAC2
1.437e-02	-4.24	LAMP_3	prosite domains	PS51407	4	1	12186	44	CD68
1.437e-02	-4.24	HIGD1A (HIG1 hypoxia inducible domain family member 1A)	protein interactions	25994	71	2	19454	50	UNC93B1,P2RY6
1.439e-02	-4.24	lamellipodium	cellular component	GO:0030027	203	3	19108	48	MYO9B,PLXND1,RAC2
1.439e-02	-4.24	endocytic vesicle membrane	cellular component	GO:0030666	203	3	19108	48	CD74,MARCO,RAC2
1.444e-02	-4.24	peptidyl-tyrosine modification	biological process	GO:0018212	68	2	18204	49	HCK,CSF1R
1.450e-02	-4.23	tertiary granule membrane	cellular component	GO:0070821	73	2	19108	48	ITGAX,ITGB2
1.461e-02	-4.23	Cell surface interactions at the vascular wall	REACTOME pathways	R-HSA-202733	136	3	10285	39	ITGB2,CD74,ITGAX
1.470e-02	-4.22	regulation of cellular component size	biological process	GO:0032535	352	4	18204	49	PLEK,NCKAP1L,HCK,PREX1
1.476e-02	-4.22	ITGB2 (integrin subunit beta 2)	protein interactions	3689	72	2	19454	50	ITGB2,ITGAX
1.476e-02	-4.22	FAM234B (family with sequence similarity 234 member B)	protein interactions	57613	72	2	19454	50	ITM2B,RAC2
1.492e-02	-4.21	PTDSS1 (phosphatidylserine synthase 1)	protein interactions	9791	201	3	19454	50	RAC2,CTSB,RBM47
1.498e-02	-4.20	Atg12-Atg5-Atg16 complex	cellular component	GO:0034274	6	1	19108	48	WDFY3
1.498e-02	-4.20	mRNA editing complex	cellular component	GO:0045293	6	1	19108	48	RBM47
1.512e-02	-4.19	positive regulation of leukocyte differentiation	biological process	GO:1902107	193	3	18204	49	NCKAP1L,ZFP36L1,CD74
1.512e-02	-4.19	positive regulation of hemopoiesis	biological process	GO:1903708	193	3	18204	49	CD74,ZFP36L1,NCKAP1L
1.518e-02	-4.19	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	29	16828	46	NCKAP1L,GAB1,NCAM2,ARHGAP15,SMPD4,CSF1R,WDFY3,MFNG,CTSB,PLEK,SPOCK3,SH2B3,MARCO,GCH1,QSOX1,GAS7,ABR,ITGAX,RAC2,ZFP36L1,ELMO1,MYO1F,ITM2B,GULP1,PREX1,HCK,PLXND1,CPN1,ZNRF2
1.526e-02	-4.18	antigen processing and presentation of peptide antigen	biological process	GO:0048002	70	2	18204	49	UNC93B1,CD74
1.530e-02	-4.18	CKAP4 (cytoskeleton associated protein 4)	protein interactions	10970	571	5	19454	50	UNC93B1,P2RY6,SMPD4,RAC2,CTSB
1.531e-02	-4.18	RhoGEF	pfam domains	PF00621	70	2	17795	48	ABR,PREX1
1.531e-02	-4.18	CERS2 (ceramide synthase 2)	protein interactions	29956	203	3	19454	50	UNC93B1,P2RY6,RAC2
1.532e-02	-4.18	CGB1 (chorionic gonadotropin subunit beta 1)	protein interactions	114335	6	1	19454	50	ZNRF2
1.532e-02	-4.18	ITGAX (integrin subunit alpha X)	protein interactions	3687	6	1	19454	50	ITGB2
1.533e-02	-4.18	regulation of response to cytokine stimulus	biological process	GO:0060759	194	3	18204	49	SH2B3,CD74,RBM47
1.535e-02	-4.18	DH-domain	interpro domains	IPR000219	70	2	18521	50	ABR,PREX1
1.538e-02	-4.17	signaling receptor binding	molecular function	GO:0005102	1493	9	18094	48	MARCO,FYB1,UNC93B1,MYO9B,SH2B3,CD74,ITGB2,ITGAX,HCK
1.554e-02	-4.16	KCNK1 (potassium two pore domain channel subfamily K member 1)	protein interactions	3775	74	2	19454	50	UNC93B1,CMTM6
1.554e-02	-4.16	COG1 (component of oligomeric golgi complex 1)	protein interactions	9382	74	2	19454	50	UNC93B1,P2RY6
1.554e-02	-4.16	COG7 (component of oligomeric golgi complex 7)	protein interactions	91949	74	2	19454	50	UNC93B1,P2RY6
1.557e-02	-4.16	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	6	16828	46	WDFY3,ELMO1,ZFP36L1,CD74,CPN1,HCK
1.568e-02	-4.16	localization within membrane	biological process	GO:0051668	549	5	18204	49	ITGB2,RAPGEF6,CMTM6,FYB1,NCF1
1.573e-02	-4.15	CALR (calreticulin)	protein interactions	811	376	4	19454	50	NDUFS2,P2RY6,CTSB,LPP
1.576e-02	-4.15	DBL_dom_sf	interpro domains	IPR035899	71	2	18521	50	PREX1,ABR
1.581e-02	-4.15	CTPase activity	molecular function	GO:0043273	6	1	18094	48	ENTPD1
1.581e-02	-4.15	ADP phosphatase activity	molecular function	GO:0043262	6	1	18094	48	ENTPD1
1.581e-02	-4.15	thiol oxidase activity	molecular function	GO:0016972	6	1	18094	48	QSOX1
1.592e-02	-4.14	CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1)	protein interactions	54901	206	3	19454	50	RAC2,UNC93B1,P2RY6
1.594e-02	-4.14	CHP1 (calcineurin like EF-hand protein 1)	protein interactions	11261	75	2	19454	50	UNC93B1,P2RY6
1.594e-02	-4.14	SPTLC2 (serine palmitoyltransferase long chain base subunit 2)	protein interactions	9517	75	2	19454	50	UNC93B1,P2RY6
1.604e-02	-4.13	positive regulation of macrophage proliferation	biological process	GO:0120041	6	1	18204	49	CSF1R
1.604e-02	-4.13	regulation of endothelial tube morphogenesis	biological process	GO:1901509	6	1	18204	49	ITGAX
1.604e-02	-4.13	enucleate erythrocyte development	biological process	GO:0048822	6	1	18204	49	RAC2
1.604e-02	-4.13	sphingomyelin catabolic process	biological process	GO:0006685	6	1	18204	49	SMPD4
1.604e-02	-4.13	negative regulation of amine metabolic process	biological process	GO:0033239	6	1	18204	49	ITGB2
1.604e-02	-4.13	positive regulation of prostaglandin biosynthetic process	biological process	GO:0031394	6	1	18204	49	CD74
1.607e-02	-4.13	cargo receptor activity	molecular function	GO:0038024	73	2	18094	48	MARCO,ITGB2
1.608e-02	-4.13	PH_BEACH	pfam domains	PF14844	6	1	17795	48	WDFY3
1.608e-02	-4.13	Integrin_b_cyt	pfam domains	PF08725	6	1	17795	48	ITGB2
1.608e-02	-4.13	ELMO_CED12	pfam domains	PF04727	6	1	17795	48	ELMO1
1.608e-02	-4.13	Integrin_B_tail	pfam domains	PF07965	6	1	17795	48	ITGB2
1.609e-02	-4.13	Integrin_bsu_cyt_dom	interpro domains	IPR014836	6	1	18521	50	ITGB2
1.609e-02	-4.13	ELMO_dom	interpro domains	IPR006816	6	1	18521	50	ELMO1
1.609e-02	-4.13	positive regulation of chemokine production	biological process	GO:0032722	72	2	18204	49	CSF1R,CD74
1.623e-02	-4.12	positive regulation of cell population proliferation	biological process	GO:0008284	992	7	18204	49	NCKAP1L,P2RY6,CSF1R,CD74,RAC2,ITGAX,HCK
1.627e-02	-4.12	protein-containing complex binding	molecular function	GO:0044877	1772	10	18094	48	NCKAP1L,FYB1,GCH1,MYO1F,MYO9B,CTSB,CD74,ITGB2,ITGAX,GAS7
1.633e-02	-4.11	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	protein interactions	51144	208	3	19454	50	CTSB,UNC93B1,P2RY6
1.640e-02	-4.11	positive regulation of protein-containing complex assembly	biological process	GO:0031334	199	3	18204	49	NCKAP1L,PLEK,HCK
1.648e-02	-4.11	endosome	cellular component	GO:0005768	1067	7	19108	48	ITM2B,CMTM6,ZNRF2,CTSB,CD68,CD74,UNC93B1
1.652e-02	-4.10	endothelial cell migration	biological process	GO:0043542	73	2	18204	49	PLXND1,GAB1
1.654e-02	-4.10	ATP1B3 (ATPase Na+/K+ transporting subunit beta 3)	protein interactions	483	209	3	19454	50	P2RY6,UNC93B1,RAC2
1.657e-02	-4.10	COPA (COPI coat complex subunit alpha)	protein interactions	1314	382	4	19454	50	NCF1,CD74,P2RY6,UNC93B1
1.676e-02	-4.09	ADGRL2 (adhesion G protein-coupled receptor L2)	protein interactions	23266	77	2	19454	50	RAC2,UNC93B1
1.676e-02	-4.09	DYM (dymeclin)	protein interactions	54808	77	2	19454	50	UNC93B1,P2RY6
1.676e-02	-4.09	TNS3 (tensin 3)	protein interactions	64759	77	2	19454	50	RAC2,GAB1
1.676e-02	-4.09	PALD1 (phosphatase domain containing paladin 1)	protein interactions	27143	77	2	19454	50	P2RY6,RAC2
1.691e-02	-4.08	plasma membrane protein complex	cellular component	GO:0098797	600	5	19108	48	CD74,ITGB2,RAC2,ITGAX,NCF1
1.696e-02	-4.08	CRKL (CRK like proto-oncogene, adaptor protein)	protein interactions	1399	211	3	19454	50	HCK,ELMO1,GAB1
1.697e-02	-4.08	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	14	16828	46	MYO9B,PLEK,SPOCK3,MYO1F,WDFY3,ELMO1,TFEB,GAB1,NCAM2,GULP1,GAS7,ABR,GCH1,PREX1
1.703e-02	-4.07	immune response-regulating signaling pathway	biological process	GO:0002764	368	4	18204	49	HCK,FYB1,UNC93B1,NCKAP1L
1.703e-02	-4.07	activation of immune response	biological process	GO:0002253	368	4	18204	49	FYB1,HCK,UNC93B1,NCKAP1L
1.705e-02	-4.07	Phagosome	KEGG pathways	ko04145	152	3	7161	26	MARCO,ITGB2,NCF1
1.705e-02	-4.07	Phagosome	KEGG pathways	hsa04145	152	3	7161	26	NCF1,MARCO,ITGB2
1.706e-02	-4.07	regulation of protein polymerization	biological process	GO:0032271	202	3	18204	49	NCKAP1L,PREX1,HCK
1.709e-02	-4.07	human chr12q24.12	chromosome location	human chr12q24.12	9	1	26134	50	SH2B3
1.709e-02	-4.07	human chr14q22.2	chromosome location	human chr14q22.2	9	1	26134	50	GCH1
1.718e-02	-4.06	OS9 (OS9 endoplasmic reticulum lectin)	protein interactions	10956	212	3	19454	50	P2RY6,UNC93B1,CTSB
1.719e-02	-4.06	secretory vesicle	cellular component	GO:0099503	1076	7	19108	48	NCKAP1L,ITGB2,CTSB,ITGAX,QSOX1,CD68,CMTM6
1.726e-02	-4.06	external side of plasma membrane	cellular component	GO:0009897	396	4	19108	48	CD74,ITGB2,CTSB,ITGAX
1.728e-02	-4.06	negative regulation of cell-cell adhesion	biological process	GO:0022408	203	3	18204	49	CD74,TNFAIP8L2,SH2B3
1.739e-02	-4.05	PPP6C (protein phosphatase 6 catalytic subunit)	protein interactions	5537	213	3	19454	50	ZNRF2,P2RY6,UNC93B1
1.747e-02	-4.05	small molecule binding	molecular function	GO:0036094	6197	24	18094	48	RAPGEF6,NDUFS2,HCK,WDFY3,CPN1,SPOCK3,DAPP1,LPP,MYO1F,RAC2,MYO9B,ZNRF2,ITGB2,GCH1,PLEK,ZFP36L1,CSF1R,NCF1,SMPD4,ENTPD1,MFNG,ITGAX,QSOX1,ITM2B
1.759e-02	-4.04	CANT1 (calcium activated nucleotidase 1)	protein interactions	124583	79	2	19454	50	ITM2B,MFNG
1.759e-02	-4.04	ATAD1 (ATPase family AAA domain containing 1)	protein interactions	84896	79	2	19454	50	RAC2,UNC93B1
1.761e-02	-4.04	NCAPD2 (non-SMC condensin I complex subunit D2)	protein interactions	9918	214	3	19454	50	CD74,UNC93B1,P2RY6
1.782e-02	-4.03	XPO5 (exportin 5)	protein interactions	57510	215	3	19454	50	UNC93B1,P2RY6,CTSB
1.786e-02	-4.03	ZCCHC24 (zinc finger CCHC-type containing 24)	protein interactions	219654	7	1	19454	50	RBM47
1.786e-02	-4.03	TLR8 (toll like receptor 8)	protein interactions	51311	7	1	19454	50	UNC93B1
1.804e-02	-4.01	ATP2B1 (ATPase plasma membrane Ca2+ transporting 1)	protein interactions	490	216	3	19454	50	RAC2,UNC93B1,P2RY6
1.811e-02	-4.01	-	gene3d domains	2.40.160.110	6	1	14470	44	CD68
1.829e-02	-4.00	cellular process	biological process	GO:0009987	14996	46	18204	49	RGS19,LPP,ITGB2,CD68,MYO1F,NCKAP1L,SMPD4,ARHGAP15,CSF1R,QSOX1,GAB1,PREX1,SH2B3,GAS7,PLXND1,ENTPD1,ZFP36L1,PLEK,UNC93B1,MFNG,NCF1,WDFY3,P2RY6,SLCO2B1,GCH1,FYB1,HCK,RBM47,CMTM6,TNFAIP8L2,DAPP1,RAC2,MARCO,CD74,LRMDA,CPN1,NCAM2,CTSB,GULP1,TFEB,MYO9B,RAPGEF6,ABR,ITGAX,ELMO1,NDUFS2
1.835e-02	-4.00	PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)	protein interactions	5295	394	4	19454	50	RAC2,HCK,CSF1R,GAB1
1.840e-02	-4.00	actin filament binding	molecular function	GO:0051015	211	3	18094	48	MYO9B,GAS7,MYO1F
1.840e-02	-4.00	regulation of leukocyte activation	biological process	GO:0002694	572	5	18204	49	NCKAP1L,TNFAIP8L2,ZFP36L1,RAC2,CD74
1.843e-02	-3.99	sphingomyelin phosphodiesterase activity	molecular function	GO:0004767	7	1	18094	48	SMPD4
1.843e-02	-3.99	MHC class II protein binding	molecular function	GO:0042289	7	1	18094	48	CD74
1.843e-02	-3.99	CAND2 (cullin associated and neddylation dissociated 2 (putative))	protein interactions	23066	81	2	19454	50	P2RY6,UNC93B1
1.848e-02	-3.99	caveola	cellular component	GO:0005901	83	2	19108	48	HCK,ENTPD1
1.849e-02	-3.99	TNPO2 (transportin 2)	protein interactions	30000	218	3	19454	50	UNC93B1,GCH1,CD68
1.850e-02	-3.99	Viral myocarditis	KEGG pathways	hsa05416	58	2	7161	26	RAC2,ITGB2
1.858e-02	-3.99	apical plasma membrane	cellular component	GO:0016324	405	4	19108	48	RAPGEF6,P2RY6,SLCO2B1,CTSB
1.864e-02	-3.98	regulation of apoptotic process	biological process	GO:0042981	1518	9	18204	49	HCK,CTSB,ZFP36L1,CD74,CSF1R,GCH1,NCKAP1L,TNFAIP8L2,PLXND1
1.865e-02	-3.98	oxidoreductase activity, acting on NAD(P)H	molecular function	GO:0016651	79	2	18094	48	NDUFS2,NCF1
1.867e-02	-3.98	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	18	16828	46	ITGAX,GAS7,PREX1,QSOX1,SPOCK3,PLEK,P2RY6,MARCO,ITM2B,NCAM2,NCKAP1L,TFEB,ZFP36L1,GAB1,ELMO1,WDFY3,SMPD4,MYO1F
1.869e-02	-3.98	response to interleukin-3	biological process	GO:0036015	7	1	18204	49	SH2B3
1.869e-02	-3.98	lamellipodium morphogenesis	biological process	GO:0072673	7	1	18204	49	MYO9B
1.869e-02	-3.98	regulation of isomerase activity	biological process	GO:0010911	7	1	18204	49	ITGB2
1.869e-02	-3.98	positive regulation of dendritic cell antigen processing and presentation	biological process	GO:0002606	7	1	18204	49	CD74
1.869e-02	-3.98	actin polymerization-dependent cell motility	biological process	GO:0070358	7	1	18204	49	NCKAP1L
1.869e-02	-3.98	tetrahydrofolate biosynthetic process	biological process	GO:0046654	7	1	18204	49	GCH1
1.869e-02	-3.98	platelet degranulation	biological process	GO:0002576	7	1	18204	49	PLEK
1.869e-02	-3.98	regulation of macrophage proliferation	biological process	GO:0120040	7	1	18204	49	CSF1R
1.869e-02	-3.98	chorio-allantoic fusion	biological process	GO:0060710	7	1	18204	49	ZFP36L1
1.869e-02	-3.98	regulation of removal of superoxide radicals	biological process	GO:2000121	7	1	18204	49	GCH1
1.869e-02	-3.98	regulation of mast cell proliferation	biological process	GO:0070666	7	1	18204	49	RAC2
1.869e-02	-3.98	regulation of TORC2 signaling	biological process	GO:1903939	7	1	18204	49	NCKAP1L
1.869e-02	-3.98	tetrahydrobiopterin biosynthetic process	biological process	GO:0006729	7	1	18204	49	GCH1
1.869e-02	-3.98	positive regulation of isomerase activity	biological process	GO:0010912	7	1	18204	49	ITGB2
1.869e-02	-3.98	cellular response to interleukin-3	biological process	GO:0036016	7	1	18204	49	SH2B3
1.869e-02	-3.98	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	biological process	GO:0031086	7	1	18204	49	ZFP36L1
1.869e-02	-3.98	bradykinin catabolic process	biological process	GO:0010815	7	1	18204	49	CPN1
1.869e-02	-3.98	regulation of myosin-light-chain-phosphatase activity	biological process	GO:0035507	7	1	18204	49	NCKAP1L
1.869e-02	-3.98	positive regulation of gamma-delta T cell differentiation	biological process	GO:0045588	7	1	18204	49	NCKAP1L
1.873e-02	-3.98	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	48	SPOCK3
1.875e-02	-3.98	Integrin_bsu_tail	interpro domains	IPR012896	7	1	18521	50	ITGB2
1.875e-02	-3.98	Integrin_bsu_tail_dom_sf	interpro domains	IPR036349	7	1	18521	50	ITGB2
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPOCK3
1.875e-02	-3.98	MYSc_Myo1	interpro domains	IPR036072	7	1	18521	50	MYO1F
1.882e-02	-3.97	MET activates PTPN11	REACTOME pathways	R-HSA-8865999	5	1	10285	39	GAB1
1.886e-02	-3.97	ANKRD52 (ankyrin repeat domain 52)	protein interactions	283373	82	2	19454	50	ZNRF2,ENTPD1
1.886e-02	-3.97	OSBPL9 (oxysterol binding protein like 9)	protein interactions	114883	82	2	19454	50	GCH1,RAC2
1.893e-02	-3.97	SCFD1 (sec1 family domain containing 1)	protein interactions	23256	220	3	19454	50	RAC2,P2RY6,UNC93B1
1.913e-02	-3.96	positive regulation of GTPase activity	biological process	GO:0043547	211	3	18204	49	PREX1,RAPGEF6,ABR
1.916e-02	-3.95	ERLIN2 (ER lipid raft associated 2)	protein interactions	11160	221	3	19454	50	UNC93B1,P2RY6,CTSB
1.917e-02	-3.95	regulation of protein targeting	biological process	GO:1903533	79	2	18204	49	ITGB2,RAC2
1.929e-02	-3.95	localization	biological process	GO:0051179	4474	19	18204	49	NDUFS2,RAPGEF6,ELMO1,TFEB,CD74,NCF1,MARCO,ITGB2,CD68,GULP1,MYO1F,CMTM6,PLEK,UNC93B1,HCK,ZFP36L1,FYB1,P2RY6,SLCO2B1
1.939e-02	-3.94	PDGFRB (platelet derived growth factor receptor beta)	protein interactions	5159	222	3	19454	50	GAB1,CSF1R,RAC2
1.939e-02	-3.94	YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)	protein interactions	10971	1076	7	19454	50	TFEB,ZNRF2,RAPGEF6,CD74,ZFP36L1,GAB1,NCF1
1.944e-02	-3.94	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	32	16828	46	SPOCK3,P2RY6,MARCO,RGS19,RBM47,CTSB,MFNG,NCAM2,GAB1,NCKAP1L,TFEB,CSF1R,SMPD4,ARHGAP15,WDFY3,ABR,RAC2,ITGAX,GAS7,LPP,RAPGEF6,SLCO2B1,GULP1,ELMO1,ZFP36L1,MYO1F,ENTPD1,ZNRF2,PLXND1,HCK,PREX1,NDUFS2
1.959e-02	-3.93	regulation of T cell activation	biological process	GO:0050863	384	4	18204	49	RAC2,CD74,TNFAIP8L2,NCKAP1L
1.959e-02	-3.93	cytokine-mediated signaling pathway	biological process	GO:0019221	384	4	18204	49	HCK,CSF1R,CD74,SH2B3
1.959e-02	-3.93	regulation of leukocyte cell-cell adhesion	biological process	GO:1903037	384	4	18204	49	CD74,ITGB2,NCKAP1L,TNFAIP8L2
1.960e-02	-3.93	EMC2 (ER membrane protein complex subunit 2)	protein interactions	9694	402	4	19454	50	P2RY6,UNC93B1,NDUFS2,RAC2
1.966e-02	-3.93	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	2	14470	44	ABR,PREX1
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	CSF1R,HCK
1.985e-02	-3.92	negative regulation of cell activation	biological process	GO:0050866	214	3	18204	49	SH2B3,TNFAIP8L2,CD74
1.992e-02	-3.92	phagolysosome	cellular component	GO:0032010	8	1	19108	48	NCF1
1.995e-02	-3.91	Toll-Like Receptors Cascades	REACTOME pathways	R-HSA-168898	153	3	10285	39	ITGB2,UNC93B1,CTSB
2.000e-02	-3.91	receptor tyrosine kinase binding	molecular function	GO:0030971	82	2	18094	48	ITGAX,SH2B3
2.008e-02	-3.91	RINT1 (RAD50 interactor 1)	protein interactions	60561	225	3	19454	50	RAC2,UNC93B1,P2RY6
2.018e-02	-3.90	ATP5ME (ATP synthase membrane subunit e)	protein interactions	521	85	2	19454	50	P2RY6,UNC93B1
2.018e-02	-3.90	WSB2 (WD repeat and SOCS box containing 2)	protein interactions	55884	85	2	19454	50	PREX1,SMPD4
2.026e-02	-3.90	regulation of supramolecular fiber organization	biological process	GO:1902903	388	4	18204	49	PLEK,NCKAP1L,PREX1,HCK
2.032e-02	-3.90	AUP1 (AUP1 lipid droplet regulating VLDL assembly factor)	protein interactions	550	226	3	19454	50	UNC93B1,P2RY6,RAC2
2.034e-02	-3.90	regulation of lymphocyte differentiation	biological process	GO:0045619	216	3	18204	49	NCKAP1L,ZFP36L1,CD74
2.034e-02	-3.90	regulation of myeloid cell differentiation	biological process	GO:0045637	216	3	18204	49	NCKAP1L,CD74,ZFP36L1
2.038e-02	-3.89	CALML6 (calmodulin like 6)	protein interactions	163688	8	1	19454	50	GCH1
2.038e-02	-3.89	NCF1C (neutrophil cytosolic factor 1C (pseudogene))	protein interactions	654817	8	1	19454	50	NCF1
2.038e-02	-3.89	CD1D (CD1d molecule)	protein interactions	912	8	1	19454	50	CD74
2.038e-02	-3.89	MGAM (maltase-glucoamylase)	protein interactions	8972	8	1	19454	50	NCF1
2.043e-02	-3.89	immune effector process	biological process	GO:0002252	389	4	18204	49	UNC93B1,HCK,MFNG,CD74
2.056e-02	-3.88	endoderm development	biological process	GO:0007492	82	2	18204	49	ITGB2,ZFP36L1
2.057e-02	-3.88	ESYT1 (extended synaptotagmin 1)	protein interactions	23344	408	4	19454	50	RAC2,ARHGAP15,SMPD4,P2RY6
2.068e-02	-3.88	IQ_motif_EF-hand-BS	interpro domains	IPR000048	82	2	18521	50	MYO9B,MYO1F
2.068e-02	-3.88	Kinesin_motor_dom_sf	interpro domains	IPR036961	82	2	18521	50	MYO1F,MYO9B
2.073e-02	-3.88	EMC1 (ER membrane protein complex subunit 1)	protein interactions	23065	409	4	19454	50	UNC93B1,NDUFS2,P2RY6,RAC2
2.079e-02	-3.87	GRN (granulin precursor)	protein interactions	2896	228	3	19454	50	CTSB,RAPGEF6,CD68
2.082e-02	-3.87	Integrin_b_cyt	smart domains	SM01241	6	1	9717	34	ITGB2
2.085e-02	-3.87	PHB1 (prohibitin 1)	protein interactions	5245	1092	7	19454	50	PREX1,CD74,CTSB,UNC93B1,P2RY6,NDUFS2,RAC2
2.103e-02	-3.86	positive regulation of B cell activation	biological process	GO:0050871	83	2	18204	49	NCKAP1L,CD74
2.103e-02	-3.86	CD4 receptor binding	molecular function	GO:0042609	8	1	18094	48	CD74
2.103e-02	-3.86	Roundabout binding	molecular function	GO:0048495	8	1	18094	48	MYO9B
2.103e-02	-3.86	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	45	16828	46	WDFY3,SMPD4,GAB1,TFEB,NCAM2,SH2B3,RGS19,MARCO,PLEK,SPOCK3,CTSB,LPP,RAC2,ABR,CD68,GULP1,DAPP1,ITM2B,MYO1F,ELMO1,CMTM6,HCK,NCF1,ENTPD1,CPN1,PLXND1,MFNG,ARHGAP15,CSF1R,NCKAP1L,P2RY6,MYO9B,GCH1,QSOX1,ITGAX,GAS7,SLCO2B1,ITGB2,ZFP36L1,CD74,TNFAIP8L2,RAPGEF6,NDUFS2,PREX1,ZNRF2
2.115e-02	-3.86	supramolecular fiber organization	biological process	GO:0097435	593	5	18204	49	MYO1F,GAS7,ELMO1,RAC2,PREX1
2.122e-02	-3.85	macromolecule localization	biological process	GO:0033036	2376	12	18204	49	FYB1,ZFP36L1,SLCO2B1,CD74,NCF1,CMTM6,PLEK,UNC93B1,ITGB2,GULP1,CD68,RAPGEF6
2.127e-02	-3.85	FFAR1 (free fatty acid receptor 1)	protein interactions	2864	230	3	19454	50	WDFY3,CMTM6,UNC93B1
2.134e-02	-3.85	regulation of respiratory burst involved in inflammatory response	biological process	GO:0060264	8	1	18204	49	NCF1
2.134e-02	-3.85	regulation of neutrophil degranulation	biological process	GO:0043313	8	1	18204	49	ITGB2
2.134e-02	-3.85	negative regulation of erythrocyte differentiation	biological process	GO:0045647	8	1	18204	49	ZFP36L1
2.134e-02	-3.85	regulation of keratinocyte apoptotic process	biological process	GO:1902172	8	1	18204	49	ZFP36L1
2.134e-02	-3.85	positive regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001280	8	1	18204	49	CD74
2.134e-02	-3.85	dichotomous subdivision of an epithelial terminal unit	biological process	GO:0060600	8	1	18204	49	PLXND1
2.134e-02	-3.85	regulation of CD8-positive, alpha-beta T cell differentiation	biological process	GO:0043376	8	1	18204	49	NCKAP1L
2.134e-02	-3.85	cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:0036006	8	1	18204	49	CSF1R
2.134e-02	-3.85	regulation of mast cell chemotaxis	biological process	GO:0060753	8	1	18204	49	RAC2
2.134e-02	-3.85	tetrahydrobiopterin metabolic process	biological process	GO:0046146	8	1	18204	49	GCH1
2.134e-02	-3.85	positive regulation of CD8-positive, alpha-beta T cell activation	biological process	GO:2001187	8	1	18204	49	NCKAP1L
2.138e-02	-3.85	Myosin_TH1	pfam domains	PF06017	8	1	17795	48	MYO1F
2.138e-02	-3.85	PSI_integrin	pfam domains	PF17205	8	1	17795	48	ITGB2
2.138e-02	-3.85	Integrin_alpha	pfam domains	PF00357	8	1	17795	48	ITGAX
2.138e-02	-3.85	TIG_plexin	pfam domains	PF17960	8	1	17795	48	PLXND1
2.138e-02	-3.85	Integrin_beta	pfam domains	PF00362	8	1	17795	48	ITGB2
2.138e-02	-3.85	GDA1_CD39	pfam domains	PF01150	8	1	17795	48	ENTPD1
2.140e-02	-3.84	Integrin_bsu_VWA	interpro domains	IPR002369	8	1	18521	50	ITGB2
2.140e-02	-3.84	Integrin_beta_N	interpro domains	IPR033760	8	1	18521	50	ITGB2
2.140e-02	-3.84	PH-BEACH_dom	interpro domains	IPR023362	8	1	18521	50	WDFY3
2.140e-02	-3.84	TIG1_plexin	interpro domains	IPR041019	8	1	18521	50	PLXND1
2.140e-02	-3.84	Tyr_kinase_rcpt_3_CS	interpro domains	IPR001824	8	1	18521	50	CSF1R
2.140e-02	-3.84	Myosin_TH1	interpro domains	IPR010926	8	1	18521	50	MYO1F
2.140e-02	-3.84	GDA1_CD39_NTPase	interpro domains	IPR000407	8	1	18521	50	ENTPD1
2.147e-02	-3.84	ELMO	prosite domains	PS51335	6	1	12186	44	ELMO1
2.151e-02	-3.84	NBPF19 (NBPF member 19)	protein interactions	101060226	231	3	19454	50	P2RY6,HCK,ITGB2
2.153e-02	-3.84	TAP2 (transporter 2, ATP binding cassette subfamily B member)	protein interactions	6891	88	2	19454	50	UNC93B1,P2RY6
2.159e-02	-3.84	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	5	19454	50	DAPP1,FYB1,HCK,CSF1R,GAB1
2.160e-02	-3.84	NRAGE signals death through JNK	REACTOME pathways	R-HSA-193648	60	2	10285	39	ABR,PREX1
2.166e-02	-3.83	haematopoietic_and_lymphoid_tissue-other-normal	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-other-normal	8	1	16828	46	CSF1R
2.196e-02	-3.82	specific granule membrane	cellular component	GO:0035579	91	2	19108	48	ITGB2,CMTM6
2.199e-02	-3.82	ACKR2 (atypical chemokine receptor 2)	protein interactions	1238	89	2	19454	50	CMTM6,UNC93B1
2.199e-02	-3.82	FMNL1 (formin like 1)	protein interactions	752	89	2	19454	50	GAS7,RAC2
2.208e-02	-3.81	focal adhesion	cellular component	GO:0005925	427	4	19108	48	LPP,ITGB2,HCK,RAC2
2.225e-02	-3.81	cell leading edge	cellular component	GO:0031252	428	4	19108	48	MYO9B,PLEK,PLXND1,RAC2
2.239e-02	-3.80	unconventional myosin complex	cellular component	GO:0016461	9	1	19108	48	MYO1F
2.241e-02	-3.80	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	8	16828	46	RBM47,TFEB,NCKAP1L,ARHGAP15,ITGB2,SPOCK3,PLEK,TNFAIP8L2
2.247e-02	-3.80	EPO signaling pathway	Pathway Interaction DB	epopathway	33	2	2226	16	SH2B3,GAB1
2.254e-02	-3.79	MET activates PI3K/AKT signaling	REACTOME pathways	R-HSA-8851907	6	1	10285	39	GAB1
2.262e-02	-3.79	regulation of programmed cell death	biological process	GO:0043067	1569	9	18204	49	ZFP36L1,GCH1,CSF1R,CD74,PLXND1,TNFAIP8L2,NCKAP1L,HCK,CTSB
2.272e-02	-3.78	human chr4q21.23	chromosome location	human chr4q21.23	12	1	26134	50	WDFY3
2.290e-02	-3.78	MCTP2 (multiple C2 and transmembrane domain containing 2)	protein interactions	55784	9	1	19454	50	RAC2
2.290e-02	-3.78	RBM46 (RNA binding motif protein 46)	protein interactions	166863	9	1	19454	50	RBM47
2.290e-02	-3.78	FHAD1 (forkhead associated phosphopeptide binding domain 1)	protein interactions	114827	9	1	19454	50	RAC2
2.290e-02	-3.78	HLA-DMA (major histocompatibility complex, class II, DM alpha)	protein interactions	3108	9	1	19454	50	CD74
2.292e-02	-3.78	APAF1 (apoptotic peptidase activating factor 1)	protein interactions	317	91	2	19454	50	WDFY3,NDUFS2
2.292e-02	-3.78	PTPRJ (protein tyrosine phosphatase receptor type J)	protein interactions	5795	91	2	19454	50	P2RY6,RAC2
2.296e-02	-3.77	embryonic placenta development	biological process	GO:0001892	87	2	18204	49	ZFP36L1,TFEB
2.299e-02	-3.77	PPP6R3 (protein phosphatase 6 regulatory subunit 3)	protein interactions	55291	237	3	19454	50	CD74,P2RY6,ZNRF2
2.300e-02	-3.77	lower_third	COSMIC cancer mutations	lower_third	7961	29	16828	46	NCAM2,TFEB,NCKAP1L,ARHGAP15,WDFY3,CSF1R,MYO9B,CTSB,SPOCK3,MARCO,P2RY6,RGS19,SH2B3,GAS7,ITGAX,RAC2,ELMO1,MYO1F,ITGB2,ITM2B,DAPP1,SLCO2B1,RAPGEF6,TNFAIP8L2,PREX1,NDUFS2,PLXND1,CPN1,NCF1
2.303e-02	-3.77	axon	cellular component	GO:0030424	650	5	19108	48	WDFY3,PREX1,ABR,NCAM2,PLXND1
2.312e-02	-3.77	STX4 (syntaxin 4)	protein interactions	6810	423	4	19454	50	ITM2B,SMPD4,GAB1,RAC2
2.324e-02	-3.76	YTHDF3 (YTH N6-methyladenosine RNA binding protein F3)	protein interactions	253943	238	3	19454	50	CSF1R,RBM47,CTSB
2.324e-02	-3.76	AQP3 (aquaporin 3 (Gill blood group))	protein interactions	360	238	3	19454	50	UNC93B1,SMPD4,WDFY3
2.339e-02	-3.76	WASF1 (WASP family member 1)	protein interactions	8936	92	2	19454	50	NCF1,RAC2
2.339e-02	-3.76	MLEC (malectin)	protein interactions	9761	92	2	19454	50	UNC93B1,P2RY6
2.341e-02	-3.75	immune response-activating cell surface receptor signaling pathway	biological process	GO:0002429	228	3	18204	49	NCKAP1L,FYB1,HCK
2.344e-02	-3.75	RhoGEF	smart domains	SM00325	68	2	9717	34	PREX1,ABR
2.348e-02	-3.75	RANBP9 (RAN binding protein 9)	protein interactions	10048	425	4	19454	50	ENTPD1,GCH1,QSOX1,ITGB2
2.350e-02	-3.75	DNAJC10 (DnaJ heat shock protein family (Hsp40) member C10)	protein interactions	54431	239	3	19454	50	UNC93B1,P2RY6,CTSB
2.363e-02	-3.75	UDP phosphatase activity	molecular function	GO:0045134	9	1	18094	48	ENTPD1
2.363e-02	-3.75	NADH dehydrogenase activity	molecular function	GO:0003954	9	1	18094	48	NDUFS2
2.375e-02	-3.74	SLC1A5 (solute carrier family 1 member 5)	protein interactions	6510	240	3	19454	50	RAC2,UNC93B1,P2RY6
2.380e-02	-3.74	cell-substrate junction	cellular component	GO:0030055	437	4	19108	48	HCK,LPP,ITGB2,RAC2
2.383e-02	-3.74	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	11	19108	48	PLEK,NCF1,MYO1F,PLXND1,RAC2,MYO9B,NCAM2,GCH1,WDFY3,PREX1,ABR
2.387e-02	-3.74	FOXG1 (forkhead box G1)	protein interactions	2290	93	2	19454	50	SMPD4,MYO9B
2.387e-02	-3.74	WDR75 (WD repeat domain 75)	protein interactions	84128	93	2	19454	50	WDFY3,PLEK
2.397e-02	-3.73	marginal zone B cell differentiation	biological process	GO:0002315	9	1	18204	49	MFNG
2.397e-02	-3.73	negative regulation of antigen processing and presentation	biological process	GO:0002578	9	1	18204	49	CD68
2.397e-02	-3.73	mesendoderm development	biological process	GO:0048382	9	1	18204	49	ZFP36L1
2.397e-02	-3.73	positive regulation of antigen processing and presentation	biological process	GO:0002579	9	1	18204	49	CD74
2.397e-02	-3.73	antibacterial innate immune response	biological process	GO:0140367	9	1	18204	49	TFEB
2.397e-02	-3.73	transepithelial chloride transport	biological process	GO:0030321	9	1	18204	49	P2RY6
2.397e-02	-3.73	positive regulation of gamma-delta T cell activation	biological process	GO:0046645	9	1	18204	49	NCKAP1L
2.397e-02	-3.73	negative regulation of chemokine-mediated signaling pathway	biological process	GO:0070100	9	1	18204	49	SH2B3
2.397e-02	-3.73	regulation of mRNA 3'-end processing	biological process	GO:0031440	9	1	18204	49	ZFP36L1
2.397e-02	-3.73	toll-like receptor 9 signaling pathway	biological process	GO:0034162	9	1	18204	49	UNC93B1
2.397e-02	-3.73	respiratory burst involved in defense response	biological process	GO:0002679	9	1	18204	49	HCK
2.397e-02	-3.73	macrophage proliferation	biological process	GO:0061517	9	1	18204	49	CSF1R
2.397e-02	-3.73	microglial cell proliferation	biological process	GO:0061518	9	1	18204	49	CSF1R
2.397e-02	-3.73	folic acid-containing compound biosynthetic process	biological process	GO:0009396	9	1	18204	49	GCH1
2.397e-02	-3.73	regulation of gamma-delta T cell differentiation	biological process	GO:0045586	9	1	18204	49	NCKAP1L
2.397e-02	-3.73	dopamine biosynthetic process	biological process	GO:0042416	9	1	18204	49	GCH1
2.402e-02	-3.73	CCDC47 (coiled-coil domain containing 47)	protein interactions	57003	428	4	19454	50	RAC2,UNC93B1,P2RY6,SMPD4
2.402e-02	-3.73	BRICHOS	pfam domains	PF04089	9	1	17795	48	ITM2B
2.402e-02	-3.73	Beach	pfam domains	PF02138	9	1	17795	48	WDFY3
2.402e-02	-3.73	Plexin_RBD	pfam domains	PF20170	9	1	17795	48	PLXND1
2.402e-02	-3.73	Plexin_cytopl	pfam domains	PF08337	9	1	17795	48	PLXND1
2.402e-02	-3.73	PH_12	pfam domains	PF16457	9	1	17795	48	ELMO1
2.404e-02	-3.73	BRICHOS_dom	interpro domains	IPR007084	9	1	18521	50	ITM2B
2.404e-02	-3.73	Plexin_RBD	interpro domains	IPR046800	9	1	18521	50	PLXND1
2.404e-02	-3.73	Integrin_bsu	interpro domains	IPR015812	9	1	18521	50	ITGB2
2.404e-02	-3.73	BEACH_dom_sf	interpro domains	IPR036372	9	1	18521	50	WDFY3
2.404e-02	-3.73	Plexin_cytoplasmic_RasGAP_dom	interpro domains	IPR013548	9	1	18521	50	PLXND1
2.404e-02	-3.73	BEACH_dom	interpro domains	IPR000409	9	1	18521	50	WDFY3
2.407e-02	-3.73	Exopolyphosphatase. Domain 2	gene3d domains	3.30.420.150	8	1	14470	44	ENTPD1
2.424e-02	-3.72	Integrin_B_tail	smart domains	SM01242	7	1	9717	34	ITGB2
2.466e-02	-3.70	anchoring junction	cellular component	GO:0070161	902	6	19108	48	GAB1,FYB1,HCK,ITGB2,LPP,RAC2
2.469e-02	-3.70	Doxorubicin Metabolism Pathway	SMPDB pathways	SMP0000650	17	1	1369	2	NDUFS2
2.491e-02	-3.69	positive regulation of phosphorylation	biological process	GO:0042327	619	5	18204	49	CSF1R,NCF1,CD74,MARCO,NCKAP1L
2.496e-02	-3.69	positive regulation of protein polymerization	biological process	GO:0032273	91	2	18204	49	NCKAP1L,HCK
2.507e-02	-3.69	Extracellular matrix organization	REACTOME pathways	R-HSA-1474244	296	4	10285	39	ITGAX,CTSB,ITGB2,SPOCK3
2.520e-02	-3.68	lysosomal lumen	cellular component	GO:0043202	98	2	19108	48	CTSB,CD74
2.541e-02	-3.67	PGA4 (pepsinogen A4)	protein interactions	643847	10	1	19454	50	CD74
2.541e-02	-3.67	ATRAID (all-trans retinoic acid induced differentiation factor)	protein interactions	51374	10	1	19454	50	LPP
2.541e-02	-3.67	MYO18B (myosin XVIIIB)	protein interactions	84700	10	1	19454	50	RAC2
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	ITGB2
2.541e-02	-3.67	ANGPTL3 (angiopoietin like 3)	protein interactions	27329	10	1	19454	50	GULP1
2.548e-02	-3.67	phenol-containing compound metabolic process	biological process	GO:0018958	92	2	18204	49	CTSB,GCH1
2.558e-02	-3.67	PICALM (phosphatidylinositol binding clathrin assembly protein)	protein interactions	8301	247	3	19454	50	LPP,RAC2,RBM47
2.573e-02	-3.66	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	16	16828	46	GAS7,PLXND1,HCK,MARCO,ITM2B,SLCO2B1,GULP1,CD74,NCAM2,ELMO1,NCKAP1L,ZFP36L1,GAB1,WDFY3,ARHGAP15,SMPD4
2.573e-02	-3.66	Kinesin motor domain	gene3d domains	3.40.850.10	82	2	14470	44	MYO9B,MYO1F
2.574e-02	-3.66	INTEGRINB	prints domains	PR01186	8	1	5227	17	ITGB2
2.580e-02	-3.66	Tuberculosis	KEGG pathways	ko05152	178	3	7161	26	ITGB2,CD74,ITGAX
2.580e-02	-3.66	Tuberculosis	KEGG pathways	hsa05152	178	3	7161	26	CD74,ITGAX,ITGB2
2.581e-02	-3.66	SOCS3 (suppressor of cytokine signaling 3)	protein interactions	9021	97	2	19454	50	CSF1R,GAB1
2.581e-02	-3.66	ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase)	protein interactions	27	97	2	19454	50	RAC2,HCK
2.581e-02	-3.66	CLPTM1L (CLPTM1 like)	protein interactions	81037	97	2	19454	50	P2RY6,UNC93B1
2.587e-02	-3.65	regulation of lymphocyte proliferation	biological process	GO:0050670	237	3	18204	49	CD74,RAC2,NCKAP1L
2.595e-02	-3.65	myelofibrosis	COSMIC cancer mutations	myelofibrosis	413	4	16828	46	CSF1R,CD74,SH2B3,GULP1
2.595e-02	-3.65	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosis	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelofibrosis	413	4	16828	46	GULP1,SH2B3,CSF1R,CD74
2.598e-02	-3.65	regulation of protein-containing complex assembly	biological process	GO:0043254	419	4	18204	49	PLEK,NCKAP1L,PREX1,HCK
2.622e-02	-3.64	superoxide-generating NAD(P)H oxidase activity	molecular function	GO:0016175	10	1	18094	48	NCF1
2.622e-02	-3.64	GDP phosphatase activity	molecular function	GO:0004382	10	1	18094	48	ENTPD1
2.622e-02	-3.64	superoxide-generating NADPH oxidase activator activity	molecular function	GO:0016176	10	1	18094	48	NCF1
2.631e-02	-3.64	PTK2B (protein tyrosine kinase 2 beta)	protein interactions	2185	98	2	19454	50	ITGB2,NCF1
2.631e-02	-3.64	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	2	19454	50	RAC2,GAB1
2.632e-02	-3.64	B cell receptor signaling pathway	KEGG pathways	hsa04662	70	2	7161	26	DAPP1,RAC2
2.632e-02	-3.64	B cell receptor signaling pathway	KEGG pathways	ko04662	70	2	7161	26	DAPP1,RAC2
2.635e-02	-3.64	DH_2	prosite domains	PS50010	70	2	12186	44	PREX1,ABR
2.647e-02	-3.63	Signaling events mediated by TCPTP	Pathway Interaction DB	tcptp_pathway	36	2	2226	16	GAB1,CSF1R
2.660e-02	-3.63	cellular response to testosterone stimulus	biological process	GO:0071394	10	1	18204	49	NCF1
2.660e-02	-3.63	cellular response to salt stress	biological process	GO:0071472	10	1	18204	49	ZFP36L1
2.660e-02	-3.63	thrombin-activated receptor signaling pathway	biological process	GO:0070493	10	1	18204	49	PLEK
2.660e-02	-3.63	endothelial cell chemotaxis	biological process	GO:0035767	10	1	18204	49	GAB1
2.660e-02	-3.63	negative regulation of T cell mediated cytotoxicity	biological process	GO:0001915	10	1	18204	49	NCKAP1L
2.660e-02	-3.63	aggrephagy	biological process	GO:0035973	10	1	18204	49	WDFY3
2.666e-02	-3.62	TGFBR1 (transforming growth factor beta receptor 1)	protein interactions	7046	251	3	19454	50	PLEK,RGS19,ARHGAP15
2.668e-02	-3.62	Pept_asp_AS	interpro domains	IPR025661	10	1	18521	50	CTSB
2.668e-02	-3.62	Plexin	interpro domains	IPR031148	10	1	18521	50	PLXND1
2.678e-02	-3.62	YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)	protein interactions	7531	1150	7	19454	50	TFEB,NCAM2,SH2B3,ZFP36L1,GAB1,RAPGEF6,CD74
2.680e-02	-3.62	XPO4 (exportin 4)	protein interactions	64328	99	2	19454	50	P2RY6,UNC93B1
2.686e-02	-3.62	PRKDC (protein kinase, DNA-activated, catalytic subunit)	protein interactions	5591	661	5	19454	50	CTSB,CPN1,UNC93B1,P2RY6,NCF1
2.702e-02	-3.61	cell motility	biological process	GO:0048870	1101	7	18204	49	ELMO1,HCK,GAB1,PREX1,ITGB2,PLXND1,NCKAP1L
2.704e-02	-3.61	BEACH domain	gene3d domains	1.10.1540.10	9	1	14470	44	WDFY3
2.715e-02	-3.61	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	44	16828	46	MFNG,NCKAP1L,ARHGAP15,CSF1R,P2RY6,MYO9B,QSOX1,GCH1,ITGAX,GAS7,SLCO2B1,CD74,ZFP36L1,ITGB2,RAPGEF6,TNFAIP8L2,NDUFS2,PREX1,ZNRF2,NCAM2,GAB1,TFEB,SMPD4,WDFY3,SPOCK3,PLEK,MARCO,SH2B3,RBM47,CTSB,ABR,RAC2,CD68,ITM2B,DAPP1,GULP1,ELMO1,MYO1F,HCK,CMTM6,CPN1,ENTPD1,NCF1,PLXND1
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	HCK,CSF1R
2.727e-02	-3.60	Semaphorin interactions	REACTOME pathways	R-HSA-373755	68	2	10285	39	PLXND1,RAC2
2.727e-02	-3.60	Integrin cell surface interactions	REACTOME pathways	R-HSA-216083	68	2	10285	39	ITGAX,ITGB2
2.729e-02	-3.60	peptidase inhibitor complex	cellular component	GO:1904090	11	1	19108	48	CTSB
2.730e-02	-3.60	regulation of mononuclear cell proliferation	biological process	GO:0032944	242	3	18204	49	RAC2,CD74,NCKAP1L
2.731e-02	-3.60	SKAP1 (src kinase associated phosphoprotein 1)	protein interactions	8631	100	2	19454	50	MYO9B,FYB1
2.731e-02	-3.60	TTC27 (tetratricopeptide repeat domain 27)	protein interactions	55622	100	2	19454	50	UNC93B1,P2RY6
2.731e-02	-3.60	OPRL1 (opioid related nociceptin receptor 1)	protein interactions	4987	100	2	19454	50	RGS19,WDFY3
2.731e-02	-3.60	SYNGR1 (synaptogyrin 1)	protein interactions	9145	100	2	19454	50	UNC93B1,CMTM6
2.766e-02	-3.59	INB	smart domains	SM00187	8	1	9717	34	ITGB2
2.767e-02	-3.59	cellular component organization	biological process	GO:0016043	5636	22	18204	49	GCH1,GAS7,PLXND1,NCAM2,HCK,RAC2,SMPD4,QSOX1,MARCO,CD74,TFEB,CSF1R,MYO1F,GULP1,ITGB2,NCKAP1L,PLEK,NDUFS2,PREX1,MYO9B,RAPGEF6,ELMO1
2.772e-02	-3.59	vWFA_dom_sf	interpro domains	IPR036465	96	2	18521	50	ITGAX,ITGB2
2.773e-02	-3.59	Leishmaniasis	KEGG pathways	ko05140	72	2	7161	26	NCF1,ITGB2
2.773e-02	-3.59	Leishmaniasis	KEGG pathways	hsa05140	72	2	7161	26	ITGB2,NCF1
2.780e-02	-3.58	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	49	HCK,GAB1,CSF1R,SH2B3
2.781e-02	-3.58	FAR1 (fatty acyl-CoA reductase 1)	protein interactions	84188	101	2	19454	50	P2RY6,UNC93B1
2.781e-02	-3.58	CGRRF1 (cell growth regulator with ring finger domain 1)	protein interactions	10668	101	2	19454	50	ITGB2,NDUFS2
2.781e-02	-3.58	NBAS (NBAS subunit of NRZ tethering complex)	protein interactions	51594	101	2	19454	50	P2RY6,UNC93B1
2.792e-02	-3.58	PLEK (pleckstrin)	protein interactions	5341	11	1	19454	50	PLEK
2.792e-02	-3.58	LCN15 (lipocalin 15)	protein interactions	389812	11	1	19454	50	MYO9B
2.792e-02	-3.58	MS4A7 (membrane spanning 4-domains A7)	protein interactions	58475	11	1	19454	50	ITGB2
2.792e-02	-3.58	LAT2 (linker for activation of T cells family member 2)	protein interactions	7462	11	1	19454	50	GAB1
2.792e-02	-3.58	RBP7 (retinol binding protein 7)	protein interactions	116362	11	1	19454	50	DAPP1
2.792e-02	-3.58	GHSR (growth hormone secretagogue receptor)	protein interactions	2693	11	1	19454	50	P2RY6
2.792e-02	-3.58	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	50	NCF1
2.810e-02	-3.57	leukocyte homeostasis	biological process	GO:0001776	97	2	18204	49	NCKAP1L,SH2B3
2.825e-02	-3.57	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	13	16828	46	SPOCK3,PLEK,MYO9B,NCAM2,GAB1,TFEB,ELMO1,WDFY3,MYO1F,ABR,GAS7,PREX1,GCH1
2.832e-02	-3.56	DOCK5 (dedicator of cytokinesis 5)	protein interactions	80005	102	2	19454	50	RAC2,ELMO1
2.832e-02	-3.56	GRAP2 (GRB2 related adaptor protein 2)	protein interactions	9402	102	2	19454	50	CSF1R,GAB1
2.832e-02	-3.56	TMX3 (thioredoxin related transmembrane protein 3)	protein interactions	54495	102	2	19454	50	P2RY6,UNC93B1
2.853e-02	-3.56	PH_BEACH	prosite domains	PS51783	8	1	12186	44	WDFY3
2.853e-02	-3.56	TH1	prosite domains	PS51757	8	1	12186	44	MYO1F
2.853e-02	-3.56	GDA1_CD39_NTPASE	prosite domains	PS01238	8	1	12186	44	ENTPD1
2.853e-02	-3.56	RECEPTOR_TYR_KIN_III	prosite domains	PS00240	8	1	12186	44	CSF1R
2.875e-02	-3.55	human chr17p13.1	chromosome location	human chr17p13.1	138	2	26134	50	GAS7,CD68
2.877e-02	-3.55	regulation of leukocyte mediated immunity	biological process	GO:0002703	247	3	18204	49	ITGB2,NCKAP1L,RAC2
2.880e-02	-3.55	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	molecular function	GO:0016670	11	1	18094	48	QSOX1
2.880e-02	-3.55	complement component C3b binding	molecular function	GO:0001851	11	1	18094	48	ITGB2
2.880e-02	-3.55	nitric-oxide synthase binding	molecular function	GO:0050998	11	1	18094	48	CD74
2.884e-02	-3.55	SERPINB2 (serpin family B member 2)	protein interactions	5055	103	2	19454	50	LPP,RAPGEF6
2.903e-02	-3.54	SH3DOMAIN	prints domains	PR00452	83	2	5227	17	HCK,MYO1F
2.920e-02	-3.53	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	4	19454	50	SH2B3,GAB1,DAPP1,HCK
2.922e-02	-3.53	positive regulation of chemokine (C-X-C motif) ligand 2 production	biological process	GO:2000343	11	1	18204	49	CD74
2.922e-02	-3.53	positive regulation of integrin activation	biological process	GO:0033625	11	1	18204	49	PLEK
2.922e-02	-3.53	regulation of response to reactive oxygen species	biological process	GO:1901031	11	1	18204	49	GCH1
2.922e-02	-3.53	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	49	SH2B3
2.922e-02	-3.53	regulation of gamma-delta T cell activation	biological process	GO:0046643	11	1	18204	49	NCKAP1L
2.922e-02	-3.53	heme catabolic process	biological process	GO:0042167	11	1	18204	49	SLCO2B1
2.922e-02	-3.53	leukocyte aggregation	biological process	GO:0070486	11	1	18204	49	RAC2
2.922e-02	-3.53	pigment catabolic process	biological process	GO:0046149	11	1	18204	49	SLCO2B1
2.928e-02	-3.53	OATP	pfam domains	PF03137	11	1	17795	48	SLCO2B1
2.931e-02	-3.53	Pept_his_AS	interpro domains	IPR025660	11	1	18521	50	CTSB
2.931e-02	-3.53	OATP	interpro domains	IPR004156	11	1	18521	50	SLCO2B1
2.936e-02	-3.53	CTDSP1 (CTD small phosphatase 1)	protein interactions	58190	104	2	19454	50	CSF1R,RAC2
2.936e-02	-3.53	COG4 (component of oligomeric golgi complex 4)	protein interactions	25839	104	2	19454	50	UNC93B1,NDUFS2
2.972e-02	-3.52	positive regulation of interleukin-6 production	biological process	GO:0032755	100	2	18204	49	CD74,UNC93B1
2.974e-02	-3.52	SCAR complex	cellular component	GO:0031209	12	1	19108	48	NCKAP1L
2.988e-02	-3.51	SLC27A4 (solute carrier family 27 member 4)	protein interactions	10999	105	2	19454	50	UNC93B1,P2RY6
2.988e-02	-3.51	CIAO2B (cytosolic iron-sulfur assembly component 2B)	protein interactions	51647	105	2	19454	50	P2RY6,UNC93B1
2.988e-02	-3.51	AKTIP (AKT interacting protein)	protein interactions	64400	105	2	19454	50	ZNRF2,NDUFS2
2.995e-02	-3.51	Cross-presentation of particulate exogenous antigens (phagosomes)	REACTOME pathways	R-HSA-1236973	8	1	10285	39	NCF1
2.995e-02	-3.51	Phosphate bond hydrolysis by NTPDase proteins	REACTOME pathways	R-HSA-8850843	8	1	10285	39	ENTPD1
3.000e-02	-3.51	Cytochrome c1, transmembrane anchor, C-terminal	gene3d domains	1.20.5.100	10	1	14470	44	ITGB2
3.023e-02	-3.50	apical part of cell	cellular component	GO:0045177	471	4	19108	48	CTSB,SLCO2B1,RAPGEF6,P2RY6
3.027e-02	-3.50	platelet activation	biological process	GO:0030168	101	2	18204	49	PLEK,ENTPD1
3.027e-02	-3.50	regulation of carbohydrate biosynthetic process	biological process	GO:0043255	101	2	18204	49	P2RY6,PLEK
3.036e-02	-3.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	5	19454	50	FYB1,PREX1,ITM2B,GAB1,RAPGEF6
3.042e-02	-3.49	AMPD3 (adenosine monophosphate deaminase 3)	protein interactions	272	12	1	19454	50	ITGB2
3.042e-02	-3.49	Ppp2r3a (protein phosphatase 2, regulatory subunit B'', alpha)	protein interactions	235542	12	1	19454	50	LPP
3.042e-02	-3.49	PNMT (phenylethanolamine N-methyltransferase)	protein interactions	5409	12	1	19454	50	HCK
3.042e-02	-3.49	ADGRB3 (adhesion G protein-coupled receptor B3)	protein interactions	577	12	1	19454	50	ELMO1
3.042e-02	-3.49	SOWAHB (sosondowah ankyrin repeat domain family member B)	protein interactions	345079	12	1	19454	50	RAPGEF6
3.042e-02	-3.49	FUT4 (fucosyltransferase 4)	protein interactions	2526	12	1	19454	50	ITGB2
3.042e-02	-3.49	ROPN1L (rhophilin associated tail protein 1 like)	protein interactions	83853	12	1	19454	50	CD74
3.042e-02	-3.49	NCF4 (neutrophil cytosolic factor 4)	protein interactions	4689	12	1	19454	50	NCF1
3.065e-02	-3.49	Bacterial invasion of epithelial cells	KEGG pathways	ko05100	76	2	7161	26	GAB1,ELMO1
3.065e-02	-3.49	Bacterial invasion of epithelial cells	KEGG pathways	hsa05100	76	2	7161	26	GAB1,ELMO1
3.078e-02	-3.48	small_intestine	COSMIC cancer mutations	small_intestine	250	3	16828	46	PLXND1,CSF1R,PREX1
3.082e-02	-3.48	regulation of phagocytosis	biological process	GO:0050764	102	2	18204	49	NCKAP1L,HCK
3.092e-02	-3.48	GEMIN4 (gem nuclear organelle associated protein 4)	protein interactions	50628	266	3	19454	50	UNC93B1,P2RY6,CD74
3.093e-02	-3.48	IQGAP2 (IQ motif containing GTPase activating protein 2)	protein interactions	10788	107	2	19454	50	UNC93B1,CD74
3.093e-02	-3.48	TPP2 (tripeptidyl peptidase 2)	protein interactions	7174	107	2	19454	50	CD74,P2RY6
3.100e-02	-3.47	RHOA (ras homolog family member A)	protein interactions	387	1186	7	19454	50	PREX1,GAB1,SMPD4,NDUFS2,RAC2,MYO9B,ABR
3.107e-02	-3.47	BRICHOS	smart domains	SM01039	9	1	9717	34	ITM2B
3.107e-02	-3.47	Beach	smart domains	SM01026	9	1	9717	34	WDFY3
3.109e-02	-3.47	electron transfer activity	molecular function	GO:0009055	104	2	18094	48	NCF1,NDUFS2
3.122e-02	-3.47	catabolic process	biological process	GO:0009056	1936	10	18204	49	ZFP36L1,ENTPD1,SMPD4,RGS19,TFEB,CPN1,SLCO2B1,WDFY3,CTSB,ZNRF2
3.138e-02	-3.46	prostaglandin transmembrane transporter activity	molecular function	GO:0015132	12	1	18094	48	SLCO2B1
3.138e-02	-3.46	semaphorin receptor activity	molecular function	GO:0017154	12	1	18094	48	PLXND1
3.140e-02	-3.46	Antigen processing and presentation	KEGG pathways	hsa04612	77	2	7161	26	CD74,CTSB
3.140e-02	-3.46	Antigen processing and presentation	KEGG pathways	ko04612	77	2	7161	26	CTSB,CD74
3.168e-02	-3.45	TyrKc	smart domains	SM00219	80	2	9717	34	CSF1R,HCK
3.172e-02	-3.45	anatomical structure morphogenesis	biological process	GO:0009653	2225	11	18204	49	GAB1,ITGAX,MYO9B,CSF1R,MFNG,ZFP36L1,PLXND1,UNC93B1,NCKAP1L,ITGB2,GAS7
3.181e-02	-3.45	PGRMC2 (progesterone receptor membrane component 2)	protein interactions	10424	269	3	19454	50	CD74,P2RY6,RAC2
3.184e-02	-3.45	regulation of chemokine-mediated signaling pathway	biological process	GO:0070099	12	1	18204	49	SH2B3
3.184e-02	-3.45	positive thymic T cell selection	biological process	GO:0045059	12	1	18204	49	CD74
3.184e-02	-3.45	response to macrophage colony-stimulating factor	biological process	GO:0036005	12	1	18204	49	CSF1R
3.184e-02	-3.45	cellular response to thyroid hormone stimulus	biological process	GO:0097067	12	1	18204	49	CTSB
3.184e-02	-3.45	cytidine to uridine editing	biological process	GO:0016554	12	1	18204	49	RBM47
3.184e-02	-3.45	negative thymic T cell selection	biological process	GO:0045060	12	1	18204	49	CD74
3.184e-02	-3.45	regulation of prostaglandin biosynthetic process	biological process	GO:0031392	12	1	18204	49	CD74
3.190e-02	-3.45	CarboxypepD_reg	pfam domains	PF13620	12	1	17795	48	CPN1
3.194e-02	-3.44	epithelial cell migration	biological process	GO:0010631	104	2	18204	49	GAB1,PLXND1
3.194e-02	-3.44	protein polymerization	biological process	GO:0051258	104	2	18204	49	PREX1,GAS7
3.194e-02	-3.44	regulation of chemokine production	biological process	GO:0032642	104	2	18204	49	CD74,CSF1R
3.194e-02	-3.44	regulation of dephosphorylation	biological process	GO:0035303	104	2	18204	49	PLEK,NCKAP1L
3.200e-02	-3.44	COQ8B (coenzyme Q8B)	protein interactions	79934	109	2	19454	50	P2RY6,UNC93B1
3.200e-02	-3.44	B4GAT1 (beta-1,4-glucuronyltransferase 1)	protein interactions	11041	109	2	19454	50	UNC93B1,CMTM6
3.200e-02	-3.44	TMEM109 (transmembrane protein 109)	protein interactions	79073	109	2	19454	50	RAC2,UNC93B1
3.204e-02	-3.44	BEACH	prosite domains	PS50197	9	1	12186	44	WDFY3
3.204e-02	-3.44	BRICHOS	prosite domains	PS50869	9	1	12186	44	ITM2B
3.204e-02	-3.44	INTEGRIN_BETA	prosite domains	PS00243	9	1	12186	44	ITGB2
3.218e-02	-3.44	semaphorin receptor complex	cellular component	GO:0002116	13	1	19108	48	PLXND1
3.218e-02	-3.44	early phagosome	cellular component	GO:0032009	13	1	19108	48	UNC93B1
3.232e-02	-3.43	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	12	1	16828	46	CSF1R
3.235e-02	-3.43	regulation of innate immune response	biological process	GO:0045088	449	4	18204	49	NCF1,RBM47,HCK,UNC93B1
3.251e-02	-3.43	antigen processing and presentation	biological process	GO:0019882	105	2	18204	49	CD74,UNC93B1
3.251e-02	-3.43	gland morphogenesis	biological process	GO:0022612	105	2	18204	49	PLXND1,CSF1R
3.254e-02	-3.43	DKKL1 (dickkopf like acrosomal protein 1)	protein interactions	27120	110	2	19454	50	ITM2B,QSOX1
3.254e-02	-3.43	ARHGAP39 (Rho GTPase activating protein 39)	protein interactions	80728	110	2	19454	50	NCAM2,RAC2
3.254e-02	-3.43	SLC27A2 (solute carrier family 27 member 2)	protein interactions	11001	110	2	19454	50	P2RY6,UNC93B1
3.254e-02	-3.43	PLXNA1 (plexin A1)	protein interactions	5361	110	2	19454	50	RAC2,PLXND1
3.271e-02	-3.42	RDX (radixin)	protein interactions	5962	272	3	19454	50	RAC2,ITGB2,LPP
3.291e-02	-3.41	CST7 (cystatin F)	protein interactions	8530	13	1	19454	50	CTSB
3.291e-02	-3.41	C1orf74 (chromosome 1 open reading frame 74)	protein interactions	148304	13	1	19454	50	HCK
3.291e-02	-3.41	SEMA4A (semaphorin 4A)	protein interactions	64218	13	1	19454	50	PLXND1
3.291e-02	-3.41	SCG3 (secretogranin III)	protein interactions	29106	13	1	19454	50	NCAM2
3.291e-02	-3.41	MYBPC3 (myosin binding protein C3)	protein interactions	4607	13	1	19454	50	NCF1
3.291e-02	-3.41	KCNQ4 (potassium voltage-gated channel subfamily Q member 4)	protein interactions	9132	13	1	19454	50	CSF1R
3.292e-02	-3.41	Complement and coagulation cascades	KEGG pathways	ko04610	79	2	7161	26	ITGAX,ITGB2
3.292e-02	-3.41	Complement and coagulation cascades	KEGG pathways	hsa04610	79	2	7161	26	ITGAX,ITGB2
3.296e-02	-3.41	Carboxypeptidase-like, regulatory domain	gene3d domains	2.60.40.1120	11	1	14470	44	CPN1
3.307e-02	-3.41	cellular response to ketone	biological process	GO:1901655	106	2	18204	49	NCF1,P2RY6
3.307e-02	-3.41	cellular response to carbohydrate stimulus	biological process	GO:0071322	106	2	18204	49	ZFP36L1,NCF1
3.309e-02	-3.41	GIPC1 (GIPC PDZ domain containing family member 1)	protein interactions	10755	111	2	19454	50	RGS19,GULP1
3.341e-02	-3.40	immune response-regulating cell surface receptor signaling pathway	biological process	GO:0002768	262	3	18204	49	NCKAP1L,HCK,FYB1
3.347e-02	-3.40	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	7	18204	49	RAPGEF6,MYO9B,NCAM2,NCKAP1L,PLEK,GAS7,CSF1R
3.348e-02	-3.40	Cell death signalling via NRAGE, NRIF and NADE	REACTOME pathways	R-HSA-204998	76	2	10285	39	ABR,PREX1
3.350e-02	-3.40	brainstem	COSMIC cancer mutations	brainstem	3102	14	16828	46	CSF1R,ARHGAP15,WDFY3,SMPD4,NCAM2,GAB1,ELMO1,SLCO2B1,RBM47,SPOCK3,GCH1,PREX1,GAS7,ITGAX
3.363e-02	-3.39	C10orf88 (chromosome 10 open reading frame 88)	protein interactions	80007	112	2	19454	50	GULP1,RBM47
3.363e-02	-3.39	SIGLECL1 (SIGLEC family like 1)	protein interactions	284369	112	2	19454	50	CMTM6,ITM2B
3.363e-02	-3.39	UBE2V1 (ubiquitin conjugating enzyme E2 V1)	protein interactions	7335	112	2	19454	50	P2RY6,ZNRF2
3.365e-02	-3.39	epithelium migration	biological process	GO:0090132	107	2	18204	49	GAB1,PLXND1
3.395e-02	-3.38	G protein-coupled purinergic nucleotide receptor activity	molecular function	GO:0045028	13	1	18094	48	P2RY6
3.395e-02	-3.38	icosanoid transmembrane transporter activity	molecular function	GO:0071714	13	1	18094	48	SLCO2B1
3.405e-02	-3.38	CANX (calnexin)	protein interactions	821	1210	7	19454	50	CD74,ITM2B,SMPD4,NDUFS2,P2RY6,UNC93B1,RAC2
3.443e-02	-3.37	positive regulation of cell development	biological process	GO:0010720	458	4	18204	49	PLXND1,NCKAP1L,CD74,ZFP36L1
3.444e-02	-3.37	negative regulation of leukocyte degranulation	biological process	GO:0043301	13	1	18204	49	NCKAP1L
3.444e-02	-3.37	negative T cell selection	biological process	GO:0043383	13	1	18204	49	CD74
3.444e-02	-3.37	positive regulation of phagocytosis, engulfment	biological process	GO:0060100	13	1	18204	49	NCKAP1L
3.444e-02	-3.37	positive regulation of nitric-oxide synthase activity	biological process	GO:0051000	13	1	18204	49	GCH1
3.444e-02	-3.37	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	49	SH2B3
3.444e-02	-3.37	positive regulation of membrane invagination	biological process	GO:1905155	13	1	18204	49	NCKAP1L
3.444e-02	-3.37	type II interferon-mediated signaling pathway	biological process	GO:0060333	13	1	18204	49	HCK
3.444e-02	-3.37	tetrapyrrole catabolic process	biological process	GO:0033015	13	1	18204	49	SLCO2B1
3.444e-02	-3.37	positive regulation of platelet activation	biological process	GO:0010572	13	1	18204	49	PLEK
3.444e-02	-3.37	enucleate erythrocyte differentiation	biological process	GO:0043353	13	1	18204	49	RAC2
3.444e-02	-3.37	G protein-coupled purinergic nucleotide receptor signaling pathway	biological process	GO:0035589	13	1	18204	49	P2RY6
3.444e-02	-3.37	porphyrin-containing compound catabolic process	biological process	GO:0006787	13	1	18204	49	SLCO2B1
3.444e-02	-3.37	positive regulation of inositol phosphate biosynthetic process	biological process	GO:0060732	13	1	18204	49	P2RY6
3.444e-02	-3.37	positive regulation of actin filament depolymerization	biological process	GO:0030836	13	1	18204	49	PLEK
3.448e-02	-3.37	IQ	prosite domains	PS50096	81	2	12186	44	MYO9B,MYO1F
3.452e-02	-3.37	Peptidase_C1	pfam domains	PF00112	13	1	17795	48	CTSB
3.454e-02	-3.37	Peptidase_C1A	interpro domains	IPR013128	13	1	18521	50	CTSB
3.454e-02	-3.37	Peptidase_C1A_C	interpro domains	IPR000668	13	1	18521	50	CTSB
3.457e-02	-3.36	TJP2 (tight junction protein 2)	protein interactions	9414	278	3	19454	50	RAPGEF6,CD74,LPP
3.481e-02	-3.36	reactive oxygen species metabolic process	biological process	GO:0072593	109	2	18204	49	PREX1,NCF1
3.488e-02	-3.36	CYB5B (cytochrome b5 type B)	protein interactions	80777	279	3	19454	50	QSOX1,RAC2,P2RY6
3.506e-02	-3.35	negative regulation of apoptotic process	biological process	GO:0043066	914	6	18204	49	HCK,NCKAP1L,PLXND1,CD74,CSF1R,GCH1
3.520e-02	-3.35	SMC2 (structural maintenance of chromosomes 2)	protein interactions	10592	280	3	19454	50	P2RY6,UNC93B1,GULP1
3.520e-02	-3.35	SNRPE (small nuclear ribonucleoprotein polypeptide E)	protein interactions	6635	280	3	19454	50	CD74,P2RY6,UNC93B1
3.523e-02	-3.35	PAPAIN	prints domains	PR00705	11	1	5227	17	CTSB
3.524e-02	-3.35	Steroid Biosynthesis	WikiPathways	WP496	10	1	5310	19	CPN1
3.537e-02	-3.34	protein localization to membrane	biological process	GO:0072657	462	4	18204	49	FYB1,NCF1,ITGB2,RAPGEF6
3.540e-02	-3.34	FFAR3 (free fatty acid receptor 3)	protein interactions	2865	14	1	19454	50	UNC93B1
3.540e-02	-3.34	CYP1B1 (cytochrome P450 family 1 subfamily B member 1)	protein interactions	1545	14	1	19454	50	RAC2
3.540e-02	-3.34	HHLA2 (HHLA2 member of B7 family)	protein interactions	11148	14	1	19454	50	UNC93B1
3.540e-02	-3.34	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	50	P2RY6
3.540e-02	-3.34	SCGB3A1 (secretoglobin family 3A member 1)	protein interactions	92304	14	1	19454	50	MARCO
3.540e-02	-3.34	CPN1 (carboxypeptidase N subunit 1)	protein interactions	1369	14	1	19454	50	CPN1
3.540e-02	-3.34	TFEC (transcription factor EC)	protein interactions	22797	14	1	19454	50	TFEB
3.540e-02	-3.34	ITGAL (integrin subunit alpha L)	protein interactions	3683	14	1	19454	50	ITGB2
3.540e-02	-3.34	Tecpr2 (tectonin beta-propeller repeat containing 2)	protein interactions	104859	14	1	19454	50	WDFY3
3.546e-02	-3.34	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	18	16828	46	PLXND1,CPN1,NDUFS2,PREX1,MYO9B,RBM47,SH2B3,RAPGEF6,MARCO,P2RY6,ELMO1,NCKAP1L,NCAM2,MYO1F,ITGB2,ARHGAP15,WDFY3,MFNG
3.546e-02	-3.34	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	18	16828	46	RAPGEF6,P2RY6,MARCO,SH2B3,RBM47,MYO9B,MFNG,WDFY3,ARHGAP15,ITGB2,MYO1F,NCAM2,NCKAP1L,ELMO1,CPN1,PLXND1,PREX1,NDUFS2
3.554e-02	-3.34	THIOL_PROTEASE_ASN	prosite domains	PS00640	10	1	12186	44	CTSB
3.558e-02	-3.34	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	5	19454	50	DAPP1,RAC2,HCK,CSF1R,GAB1
3.561e-02	-3.34	cytoskeletal motor activity	molecular function	GO:0003774	112	2	18094	48	MYO1F,MYO9B
3.587e-02	-3.33	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	12	16828	46	SMPD4,CSF1R,WDFY3,ARHGAP15,GAB1,ELMO1,NCAM2,SLCO2B1,GCH1,PREX1,GAS7,ITGAX
3.590e-02	-3.33	regulation of response to stress	biological process	GO:0080134	1431	8	18204	49	HCK,RBM47,NCF1,CD74,GCH1,SH2B3,UNC93B1,TNFAIP8L2
3.601e-02	-3.32	nuclear envelope	cellular component	GO:0005635	498	4	19108	48	WDFY3,RAC2,GCH1,SMPD4
3.604e-02	-3.32	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051896	270	3	18204	49	SH2B3,NCF1,CSF1R
3.615e-02	-3.32	HLA-A (major histocompatibility complex, class I, A)	protein interactions	3105	283	3	19454	50	ITM2B,CTSB,RAC2
3.619e-02	-3.32	signaling adaptor activity	molecular function	GO:0035591	113	2	18094	48	SH2B3,GAB1
3.619e-02	-3.32	cell migration	biological process	GO:0016477	921	6	18204	49	PREX1,GAB1,HCK,NCKAP1L,PLXND1,ITGB2
3.624e-02	-3.32	endomembrane system	cellular component	GO:0012505	4764	18	19108	48	CD74,ITGB2,HCK,NCKAP1L,MFNG,WDFY3,SMPD4,CTSB,CMTM6,QSOX1,RGS19,ITM2B,UNC93B1,GCH1,CD68,ZNRF2,ITGAX,RAC2
3.625e-02	-3.32	membrane raft	cellular component	GO:0045121	290	3	19108	48	ITGB2,ENTPD1,HCK
3.642e-02	-3.31	EMC3 (ER membrane protein complex subunit 3)	protein interactions	55831	117	2	19454	50	RAC2,P2RY6
3.652e-02	-3.31	metalloendopeptidase inhibitor activity	molecular function	GO:0008191	14	1	18094	48	SPOCK3
3.652e-02	-3.31	Toll-like receptor binding	molecular function	GO:0035325	14	1	18094	48	UNC93B1
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	WDFY3,DAPP1,NCF1
3.670e-02	-3.30	cell morphogenesis	biological process	GO:0000902	687	5	18204	49	NCKAP1L,UNC93B1,GAS7,MYO9B,CSF1R
3.674e-02	-3.30	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	8	16828	46	RAC2,PLEK,QSOX1,ARHGAP15,SMPD4,CD74,NCAM2,ELMO1
3.680e-02	-3.30	CIAO1 (cytosolic iron-sulfur assembly component 1)	protein interactions	9391	285	3	19454	50	SMPD4,UNC93B1,P2RY6
3.688e-02	-3.30	membrane microdomain	cellular component	GO:0098857	292	3	19108	48	ITGB2,HCK,ENTPD1
3.699e-02	-3.30	DNASE1L1 (deoxyribonuclease 1 like 1)	protein interactions	1774	118	2	19454	50	PLXND1,QSOX1
3.703e-02	-3.30	angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	angioimmunoblastic_T_cell_lymphoma	269	3	16828	46	CSF1R,SH2B3,HCK
3.704e-02	-3.30	pteridine-containing compound biosynthetic process	biological process	GO:0042559	14	1	18204	49	GCH1
3.704e-02	-3.30	cellular response to oxidised low-density lipoprotein particle stimulus	biological process	GO:0140052	14	1	18204	49	CD68
3.704e-02	-3.30	positive regulation of viral entry into host cell	biological process	GO:0046598	14	1	18204	49	CD74
3.704e-02	-3.30	toll-like receptor 3 signaling pathway	biological process	GO:0034138	14	1	18204	49	UNC93B1
3.704e-02	-3.30	regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001279	14	1	18204	49	CD74
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	P2RY6
3.704e-02	-3.30	positive regulation by symbiont of entry into host	biological process	GO:0075294	14	1	18204	49	CD74
3.704e-02	-3.30	regulation of podosome assembly	biological process	GO:0071801	14	1	18204	49	HCK
3.713e-02	-3.29	G protein-coupled receptor signaling pathway	biological process	GO:0007186	1178	7	18204	49	PREX1,SH2B3,P2RY6,PLEK,RAC2,RGS19,MARCO
3.717e-02	-3.29	tissue migration	biological process	GO:0090130	113	2	18204	49	PLXND1,GAB1
3.729e-02	-3.29	MET receptor recycling	REACTOME pathways	R-HSA-8875656	10	1	10285	39	GAB1
3.729e-02	-3.29	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	39	GAB1
3.740e-02	-3.29	protein kinase binding	molecular function	GO:0019901	701	5	18094	48	PLEK,SH2B3,GCH1,ITGB2,ITGAX
3.745e-02	-3.28	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	3	19454	50	RAC2,GAB1,RAPGEF6
3.755e-02	-3.28	SEC62 (SEC62 homolog, preprotein translocation factor)	protein interactions	7095	493	4	19454	50	SMPD4,UNC93B1,P2RY6,MFNG
3.756e-02	-3.28	NOP9 (NOP9 nucleolar protein)	protein interactions	161424	119	2	19454	50	P2RY6,RBM47
3.757e-02	-3.28	myelodysplastic-myeloproliferative_neoplasm-unclassifiable	COSMIC cancer mutations	myelodysplastic-myeloproliferative_neoplasm-unclassifiable	112	2	16828	46	SH2B3,CSF1R
3.757e-02	-3.28	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic-myeloproliferative_neoplasm-unclassifiable	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic-myeloproliferative_neoplasm-unclassifiable	112	2	16828	46	CSF1R,SH2B3
3.759e-02	-3.28	human chr3p22.3	chromosome location	human chr3p22.3	20	1	26134	50	CMTM6
3.779e-02	-3.28	VDAC1 (voltage dependent anion channel 1)	protein interactions	7416	494	4	19454	50	CD74,P2RY6,NDUFS2,UNC93B1
3.788e-02	-3.27	GP6 (glycoprotein VI platelet)	protein interactions	51206	15	1	19454	50	NCF1
3.788e-02	-3.27	GLIPR1 (GLI pathogenesis related 1)	protein interactions	11010	15	1	19454	50	CMTM6
3.788e-02	-3.27	GALNT3 (polypeptide N-acetylgalactosaminyltransferase 3)	protein interactions	2591	15	1	19454	50	UNC93B1
3.788e-02	-3.27	PTPRCAP (protein tyrosine phosphatase receptor type C associated protein)	protein interactions	5790	15	1	19454	50	CMTM6
3.788e-02	-3.27	UCP3 (uncoupling protein 3)	protein interactions	7352	15	1	19454	50	RBM47
3.788e-02	-3.27	NCKAP1L (NCK associated protein 1 like)	protein interactions	3071	15	1	19454	50	GAS7
3.788e-02	-3.27	AANAT (aralkylamine N-acetyltransferase)	protein interactions	15	15	1	19454	50	P2RY6
3.814e-02	-3.27	CLPTM1 (CLPTM1 regulator of GABA type A receptor forward trafficking)	protein interactions	1209	120	2	19454	50	MFNG,UNC93B1
3.814e-02	-3.27	ANKRD13A (ankyrin repeat domain 13A)	protein interactions	88455	120	2	19454	50	UNC93B1,P2RY6
3.870e-02	-3.25	Nucleotide GPCRs	WikiPathways	WP80	11	1	5310	19	P2RY6
3.872e-02	-3.25	EIF3J (eukaryotic translation initiation factor 3 subunit J)	protein interactions	8669	121	2	19454	50	CD74,P2RY6
3.883e-02	-3.25	-	gene3d domains	6.20.240.20	13	1	14470	44	MYO9B
3.902e-02	-3.24	THIOL_PROTEASE_HIS	prosite domains	PS00639	11	1	12186	44	CTSB
3.908e-02	-3.24	1-phosphatidylinositol binding	molecular function	GO:0005545	15	1	18094	48	WDFY3
3.908e-02	-3.24	quinone binding	molecular function	GO:0048038	15	1	18094	48	NDUFS2
3.913e-02	-3.24	positive regulation of leukocyte cell-cell adhesion	biological process	GO:1903039	279	3	18204	49	CD74,ITGB2,NCKAP1L
3.925e-02	-3.24	NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria	KEGG pathways	M00143	11	1	7161	26	NDUFS2
3.925e-02	-3.24	NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria	KEGG pathways	hsa_M00143	11	1	7161	26	NDUFS2
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	RAC2,NCKAP1L
3.943e-02	-3.23	human chr2q14.2	chromosome location	human chr2q14.2	21	1	26134	50	MARCO
3.943e-02	-3.23	human chr21q21.1	chromosome location	human chr21q21.1	21	1	26134	50	NCAM2
3.943e-02	-3.23	human chr4q32.3	chromosome location	human chr4q32.3	21	1	26134	50	SPOCK3
3.964e-02	-3.23	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902166	15	1	18204	49	CD74
3.964e-02	-3.23	negative regulation of B cell apoptotic process	biological process	GO:0002903	15	1	18204	49	CD74
3.964e-02	-3.23	negative regulation of DNA damage response, signal transduction by p53 class mediator	biological process	GO:0043518	15	1	18204	49	CD74
3.964e-02	-3.23	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	biological process	GO:1900153	15	1	18204	49	ZFP36L1
3.964e-02	-3.23	p38MAPK cascade	biological process	GO:0038066	15	1	18204	49	ZFP36L1
3.964e-02	-3.23	sodium-independent organic anion transport	biological process	GO:0043252	15	1	18204	49	SLCO2B1
3.964e-02	-3.23	regulation of phagocytosis, engulfment	biological process	GO:0060099	15	1	18204	49	NCKAP1L
3.964e-02	-3.23	regulation of membrane invagination	biological process	GO:1905153	15	1	18204	49	NCKAP1L
3.964e-02	-3.23	establishment of endothelial intestinal barrier	biological process	GO:0090557	15	1	18204	49	RAPGEF6
4.018e-02	-3.21	homeostasis of number of cells	biological process	GO:0048872	282	3	18204	49	SH2B3,NCKAP1L,RAC2
4.021e-02	-3.21	multicellular organismal process	biological process	GO:0032501	6177	23	18204	49	SLCO2B1,GCH1,PREX1,GAB1,TNFAIP8L2,NCKAP1L,ITM2B,ITGB2,CSF1R,CD74,MARCO,RAC2,CTSB,NCAM2,PLXND1,SH2B3,GAS7,ZFP36L1,ENTPD1,NDUFS2,PLEK,TFEB,MFNG
4.035e-02	-3.21	SLCO3A1 (solute carrier organic anion transporter family member 3A1)	protein interactions	28232	16	1	19454	50	RAC2
4.035e-02	-3.21	GPNMB (glycoprotein nmb)	protein interactions	10457	16	1	19454	50	TFEB
4.035e-02	-3.21	REN (renin)	protein interactions	5972	16	1	19454	50	CTSB
4.035e-02	-3.21	IL1RL2 (interleukin 1 receptor like 2)	protein interactions	8808	16	1	19454	50	MYO1F
4.035e-02	-3.21	APOA5 (apolipoprotein A5)	protein interactions	116519	16	1	19454	50	CMTM6
4.035e-02	-3.21	ZSCAN4 (zinc finger and SCAN domain containing 4)	protein interactions	201516	16	1	19454	50	HCK
4.035e-02	-3.21	BGLAP (bone gamma-carboxyglutamate protein)	protein interactions	632	16	1	19454	50	CTSB
4.035e-02	-3.21	ESM1 (endothelial cell specific molecule 1)	protein interactions	11082	16	1	19454	50	ITGB2
4.035e-02	-3.21	BEST2 (bestrophin 2)	protein interactions	54831	16	1	19454	50	UNC93B1
4.043e-02	-3.21	negative regulation of programmed cell death	biological process	GO:0043069	946	6	18204	49	PLXND1,NCKAP1L,CSF1R,GCH1,CD74,HCK
4.047e-02	-3.21	ERLEC1 (endoplasmic reticulum lectin 1)	protein interactions	27248	124	2	19454	50	UNC93B1,P2RY6
4.055e-02	-3.21	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	4	16828	46	NCAM2,WDFY3,SPOCK3,GULP1
4.074e-02	-3.20	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	17	16828	46	SH2B3,RAPGEF6,PLEK,SPOCK3,MYO9B,RBM47,GULP1,SLCO2B1,WDFY3,NCKAP1L,ELMO1,CD74,NCAM2,ITGAX,ABR,PLXND1,PREX1
4.092e-02	-3.20	regulation of signaling	biological process	GO:0023051	3534	15	18204	49	RGS19,SH2B3,P2RY6,RBM47,NCF1,MARCO,CD74,CSF1R,ARHGAP15,MFNG,PLEK,NCKAP1L,PREX1,ABR,MYO9B
4.095e-02	-3.20	Signaling by FGFR4 in disease	REACTOME pathways	R-HSA-5655291	11	1	10285	39	GAB1
4.095e-02	-3.20	MET activates RAP1 and RAC1	REACTOME pathways	R-HSA-8875555	11	1	10285	39	GAB1
4.106e-02	-3.19	FAM234A (family with sequence similarity 234 member A)	protein interactions	83986	125	2	19454	50	RAC2,WDFY3
4.112e-02	-3.19	T-Cell antigen Receptor (TCR) Signaling Pathway	WikiPathways	WP69	91	2	5310	19	FYB1,SH2B3
4.113e-02	-3.19	ALDH3A2 (aldehyde dehydrogenase 3 family member A2)	protein interactions	224	298	3	19454	50	P2RY6,UNC93B1,RAC2
4.127e-02	-3.19	human chr4q23	chromosome location	human chr4q23	22	1	26134	50	DAPP1
4.138e-02	-3.18	positive regulation of cell adhesion	biological process	GO:0045785	486	4	18204	49	ITGB2,NCKAP1L,CD74,PREX1
4.156e-02	-3.18	cellular component organization or biogenesis	biological process	GO:0071840	5850	22	18204	49	MARCO,CD74,QSOX1,CSF1R,RAC2,SMPD4,NCKAP1L,MYO1F,ITGB2,PREX1,GCH1,HCK,TFEB,PLEK,GULP1,NDUFS2,ELMO1,MYO9B,RAPGEF6,PLXND1,GAS7,NCAM2
4.156e-02	-3.18	regulation of cell communication	biological process	GO:0010646	3541	15	18204	49	CSF1R,ARHGAP15,NCF1,MARCO,CD74,MFNG,NCKAP1L,PLEK,PREX1,ABR,MYO9B,RGS19,P2RY6,SH2B3,RBM47
4.158e-02	-3.18	SH3 domain binding	molecular function	GO:0017124	122	2	18094	48	NCF1,ELMO1
4.163e-02	-3.18	sodium-independent organic anion transmembrane transporter activity	molecular function	GO:0015347	16	1	18094	48	SLCO2B1
4.163e-02	-3.18	oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor	molecular function	GO:0050664	16	1	18094	48	NCF1
4.171e-02	-3.18	Regulation of RhoA activity	Pathway Interaction DB	rhoa_reg_pathway	46	2	2226	16	ABR,MYO9B
4.182e-02	-3.17	PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)	protein interactions	5496	300	3	19454	50	TFEB,P2RY6,MYO9B
4.187e-02	-3.17	MHC class II protein complex	cellular component	GO:0042613	17	1	19108	48	CD74
4.207e-02	-3.17	positive regulation of T cell differentiation	biological process	GO:0045582	121	2	18204	49	CD74,NCKAP1L
4.215e-02	-3.17	RalA downstream regulated genes	WikiPathways	WP2290	12	1	5310	19	RAC2
4.219e-02	-3.17	KPNB1 (karyopherin subunit beta 1)	protein interactions	3837	512	4	19454	50	SMPD4,UNC93B1,P2RY6,CD74
4.223e-02	-3.16	thyroid hormone generation	biological process	GO:0006590	16	1	18204	49	CTSB
4.223e-02	-3.16	positive regulation of B cell differentiation	biological process	GO:0045579	16	1	18204	49	NCKAP1L
4.223e-02	-3.16	cellular response to prostaglandin E stimulus	biological process	GO:0071380	16	1	18204	49	P2RY6
4.223e-02	-3.16	reactive oxygen species biosynthetic process	biological process	GO:1903409	16	1	18204	49	NCF1
4.223e-02	-3.16	neuron cell-cell adhesion	biological process	GO:0007158	16	1	18204	49	NCAM2
4.223e-02	-3.16	prostaglandin transport	biological process	GO:0015732	16	1	18204	49	SLCO2B1
4.223e-02	-3.16	branching involved in salivary gland morphogenesis	biological process	GO:0060445	16	1	18204	49	PLXND1
4.223e-02	-3.16	neutrophil homeostasis	biological process	GO:0001780	16	1	18204	49	SH2B3
4.226e-02	-3.16	RRM1 (ribonucleotide reductase catalytic subunit M1)	protein interactions	6240	127	2	19454	50	GCH1,NCF1
4.226e-02	-3.16	GOLPH3 (golgi phosphoprotein 3)	protein interactions	64083	127	2	19454	50	P2RY6,UNC93B1
4.231e-02	-3.16	Integrin_A_Ig_1	pfam domains	PF08441	16	1	17795	48	ITGAX
4.234e-02	-3.16	positive regulation of innate immune response	biological process	GO:0045089	288	3	18204	49	UNC93B1,HCK,RBM47
4.235e-02	-3.16	Integrin_alpha_Ig-like_1	interpro domains	IPR013649	16	1	18521	50	ITGAX
4.235e-02	-3.16	Integrin_alpha_C_CS	interpro domains	IPR018184	16	1	18521	50	ITGAX
4.235e-02	-3.16	CarboxyPept-like_regulatory	interpro domains	IPR008969	16	1	18521	50	CPN1
4.248e-02	-3.16	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	15	16828	46	MYO9B,RBM47,SPOCK3,WDFY3,TFEB,ZFP36L1,NCKAP1L,NCAM2,CD74,SLCO2B1,GULP1,GAS7,NCF1,ABR,HCK
4.248e-02	-3.16	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	15	16828	46	HCK,GAS7,NCF1,ABR,WDFY3,NCKAP1L,ZFP36L1,TFEB,NCAM2,CD74,GULP1,SLCO2B1,MYO9B,RBM47,SPOCK3
4.270e-02	-3.15	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	4	18204	49	CSF1R,NCKAP1L,MYO9B,GAS7
4.282e-02	-3.15	TMEM95 (transmembrane protein 95)	protein interactions	339168	17	1	19454	50	CMTM6
4.282e-02	-3.15	Lrr1 (leucine rich repeat protein 1)	protein interactions	69706	17	1	19454	50	WDFY3
4.282e-02	-3.15	MRAS (muscle RAS oncogene homolog)	protein interactions	22808	17	1	19454	50	RAPGEF6
4.282e-02	-3.15	PSD4 (pleckstrin and Sec7 domain containing 4)	protein interactions	23550	17	1	19454	50	GULP1
4.282e-02	-3.15	ARL4A (ADP ribosylation factor like GTPase 4A)	protein interactions	10124	17	1	19454	50	ELMO1
4.282e-02	-3.15	SMIM11 (small integral membrane protein 11)	protein interactions	54065	17	1	19454	50	UNC93B1
4.282e-02	-3.15	SYNDIG1 (synapse differentiation inducing 1)	protein interactions	79953	17	1	19454	50	UNC93B1
4.286e-02	-3.15	RAB18 (RAB18, member RAS oncogene family)	protein interactions	22931	128	2	19454	50	P2RY6,UNC93B1
4.286e-02	-3.15	FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1)	protein interactions	10160	128	2	19454	50	RAC2,RBM47
4.286e-02	-3.15	ASPH (aspartate beta-hydroxylase)	protein interactions	444	303	3	19454	50	UNC93B1,CMTM6,P2RY6
4.287e-02	-3.15	normal	COSMIC cancer mutations	normal	16	1	16828	46	CSF1R
4.293e-02	-3.15	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	17	16828	46	MARCO,SMPD4,ARHGAP15,WDFY3,GAB1,ELMO1,ZFP36L1,NCKAP1L,CD74,NCAM2,SLCO2B1,GULP1,ITM2B,PLXND1,GAS7,CPN1,HCK
4.297e-02	-3.15	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	6	19454	50	NCF1,GAB1,PREX1,ARHGAP15,NDUFS2,RAC2
4.311e-02	-3.14	human chr14q24.1	chromosome location	human chr14q24.1	23	1	26134	50	ZFP36L1
4.345e-02	-3.14	protein tyrosine kinase binding	molecular function	GO:1990782	125	2	18094	48	SH2B3,ITGAX
4.346e-02	-3.14	SCD (stearoyl-CoA desaturase)	protein interactions	6319	129	2	19454	50	RAC2,ARHGAP15
4.348e-02	-3.14	molecular function regulator activity	molecular function	GO:0098772	2079	10	18094	48	ARHGAP15,RAC2,NCKAP1L,SPOCK3,PREX1,ABR,RAPGEF6,MYO9B,ELMO1,NCF1
4.404e-02	-3.12	cell projection morphogenesis	biological process	GO:0048858	496	4	18204	49	NCKAP1L,MYO9B,GAS7,CSF1R
4.407e-02	-3.12	ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group))	protein interactions	4363	130	2	19454	50	UNC93B1,RAC2
4.415e-02	-3.12	establishment of localization	biological process	GO:0051234	3887	16	18204	49	P2RY6,SLCO2B1,ZFP36L1,HCK,CMTM6,PLEK,UNC93B1,ITGB2,GULP1,MYO1F,CD68,MARCO,CD74,NCF1,ELMO1,NDUFS2
4.417e-02	-3.12	transmembrane receptor protein tyrosine kinase adaptor activity	molecular function	GO:0005068	17	1	18094	48	SH2B3
4.417e-02	-3.12	nucleoside diphosphate phosphatase activity	molecular function	GO:0017110	17	1	18094	48	ENTPD1
4.418e-02	-3.12	nuclear membrane	cellular component	GO:0031965	314	3	19108	48	GCH1,WDFY3,SMPD4
4.457e-02	-3.11	Pept_C1	smart domains	SM00645	13	1	9717	34	CTSB
4.459e-02	-3.11	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	REACTOME pathways	R-HSA-1474151	12	1	10285	39	GCH1
4.459e-02	-3.11	Transport of organic anions	REACTOME pathways	R-HSA-879518	12	1	10285	39	SLCO2B1
4.459e-02	-3.11	P2Y receptors	REACTOME pathways	R-HSA-417957	12	1	10285	39	P2RY6
4.459e-02	-3.11	ribonucleoside triphosphate phosphatase activity	molecular function	GO:0017111	736	5	18094	48	ENTPD1,RGS19,MYO9B,GCH1,RAC2
4.468e-02	-3.11	ATP6V1H (ATPase H+ transporting V1 subunit H)	protein interactions	51606	131	2	19454	50	P2RY6,UNC93B1
4.468e-02	-3.11	EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)	protein interactions	1967	131	2	19454	50	UNC93B1,RBM47
4.481e-02	-3.11	monocyte differentiation	biological process	GO:0030224	17	1	18204	49	CSF1R
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	CD74
4.481e-02	-3.11	microvillus assembly	biological process	GO:0030033	17	1	18204	49	RAPGEF6
4.481e-02	-3.11	protein kinase C signaling	biological process	GO:0070528	17	1	18204	49	PLEK
4.481e-02	-3.11	response to hepatocyte growth factor	biological process	GO:0035728	17	1	18204	49	GAB1
4.481e-02	-3.11	regulation of integrin activation	biological process	GO:0033623	17	1	18204	49	PLEK
4.481e-02	-3.11	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902165	17	1	18204	49	CD74
4.493e-02	-3.10	RGS_subdom1/3	interpro domains	IPR024066	17	1	18521	50	RGS19
4.509e-02	-3.10	amb2 Integrin signaling	Pathway Interaction DB	amb2_neutrophils_pathway	48	2	2226	16	ITGB2,HCK
4.514e-02	-3.10	positive regulation of cytokine production	biological process	GO:0001819	500	4	18204	49	UNC93B1,CSF1R,CD74,RBM47
4.517e-02	-3.10	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	44	CSF1R,HCK
4.524e-02	-3.10	RPN2 (ribophorin II)	protein interactions	6185	762	5	19454	50	CTSB,RAC2,SMPD4,P2RY6,UNC93B1
4.529e-02	-3.09	PMF1-BGLAP (PMF1-BGLAP readthrough)	protein interactions	100527963	18	1	19454	50	CMTM6
4.529e-02	-3.09	NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2)	protein interactions	254827	18	1	19454	50	ITM2B
4.529e-02	-3.09	SLC2A14 (solute carrier family 2 member 14)	protein interactions	144195	18	1	19454	50	RAC2
4.529e-02	-3.09	PDE8A (phosphodiesterase 8A)	protein interactions	5151	18	1	19454	50	RAC2
4.529e-02	-3.09	SECTM1 (secreted and transmembrane 1)	protein interactions	6398	18	1	19454	50	GCH1
4.529e-02	-3.09	DCAF17 (DDB1 and CUL4 associated factor 17)	protein interactions	80067	18	1	19454	50	PREX1
4.529e-02	-3.09	TM4SF20 (transmembrane 4 L six family member 20)	protein interactions	79853	18	1	19454	50	CD74
4.529e-02	-3.09	FKBP8 (FKBP prolyl isomerase 8)	protein interactions	23770	524	4	19454	50	CD74,SMPD4,P2RY6,RAC2
4.530e-02	-3.09	TINF2 (TERF1 interacting nuclear factor 2)	protein interactions	26277	132	2	19454	50	ZFP36L1,LPP
4.530e-02	-3.09	TXNDC12 (thioredoxin domain containing 12)	protein interactions	51060	132	2	19454	50	CTSB,HCK
4.531e-02	-3.09	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	40	16828	46	RAPGEF6,ELMO1,ZFP36L1,CD74,ITGB2,MYO1F,ITM2B,GULP1,SLCO2B1,PLXND1,CPN1,ZNRF2,NCF1,NDUFS2,PREX1,HCK,CMTM6,MYO9B,RBM47,PLEK,SH2B3,RGS19,P2RY6,MARCO,NCKAP1L,GAB1,TFEB,NCAM2,ARHGAP15,CSF1R,SMPD4,WDFY3,MFNG,GAS7,ABR,RAC2,ITGAX,GCH1,QSOX1,LPP
4.549e-02	-3.09	chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	COSMIC cancer mutations	chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	17	1	16828	46	SH2B3
4.549e-02	-3.09	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-chronic_eosinophilic_leukaemia-hypereosinophilic_syndrome	17	1	16828	46	SH2B3
4.590e-02	-3.08	regulation of myeloid leukocyte differentiation	biological process	GO:0002761	127	2	18204	49	ZFP36L1,CD74
4.591e-02	-3.08	PIGS (phosphatidylinositol glycan anchor biosynthesis class S)	protein interactions	94005	133	2	19454	50	RAC2,UNC93B1
4.591e-02	-3.08	PLAUR (plasminogen activator, urokinase receptor)	protein interactions	5329	133	2	19454	50	HCK,ITGB2
4.596e-02	-3.08	CARBOXYPEPT_ZN_2	prosite domains	PS00133	13	1	12186	44	CPN1
4.596e-02	-3.08	CARBOXYPEPT_ZN_1	prosite domains	PS00132	13	1	12186	44	CPN1
4.597e-02	-3.08	positive regulation of organelle organization	biological process	GO:0010638	503	4	18204	49	HCK,GCH1,NCKAP1L,PLEK
4.624e-02	-3.07	cellular response to hormone stimulus	biological process	GO:0032870	504	4	18204	49	P2RY6,CTSB,GAB1,ZFP36L1
4.653e-02	-3.07	GIT2 (GIT ArfGAP 2)	protein interactions	9815	134	2	19454	50	RAC2,GCH1
4.653e-02	-3.07	FDFT1 (farnesyl-diphosphate farnesyltransferase 1)	protein interactions	2222	134	2	19454	50	UNC93B1,CD74
4.673e-02	-3.06	trunk	COSMIC cancer mutations	trunk	3554	15	16828	46	TNFAIP8L2,PLEK,SPOCK3,RBM47,ITGB2,MYO1F,ARHGAP15,WDFY3,SMPD4,NCKAP1L,TFEB,ITGAX,ABR,HCK,QSOX1
4.674e-02	-3.06	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	5	19454	50	GAB1,NCF1,WDFY3,SH2B3,CSF1R
4.680e-02	-3.06	ATP5PO (ATP synthase peripheral stalk subunit OSCP)	protein interactions	539	314	3	19454	50	P2RY6,PREX1,UNC93B1
4.716e-02	-3.05	neuron projection	cellular component	GO:0043005	1331	7	19108	48	PLXND1,NCF1,GCH1,NCAM2,ABR,PREX1,WDFY3
4.717e-02	-3.05	VDAC3 (voltage dependent anion channel 3)	protein interactions	7419	315	3	19454	50	UNC93B1,P2RY6,NDUFS2
4.720e-02	-3.05	response to organophosphorus	biological process	GO:0046683	129	2	18204	49	ZFP36L1,P2RY6
4.721e-02	-3.05	regulation of cell population proliferation	biological process	GO:0042127	1790	9	18204	49	ITGAX,HCK,SH2B3,P2RY6,NCKAP1L,RAC2,ZFP36L1,CD74,CSF1R
4.728e-02	-3.05	Ras signaling pathway	KEGG pathways	hsa04014	226	3	7161	26	GAB1,RAC2,CSF1R
4.738e-02	-3.05	maintenance of cell polarity	biological process	GO:0030011	18	1	18204	49	NCKAP1L
4.738e-02	-3.05	cell-cell junction maintenance	biological process	GO:0045217	18	1	18204	49	CSF1R
4.738e-02	-3.05	positive regulation of myelination	biological process	GO:0031643	18	1	18204	49	ITGAX
4.738e-02	-3.05	positive regulation of superoxide anion generation	biological process	GO:0032930	18	1	18204	49	ITGB2
4.738e-02	-3.05	negative regulation of platelet activation	biological process	GO:0010544	18	1	18204	49	SH2B3
4.738e-02	-3.05	regulation of dopamine metabolic process	biological process	GO:0042053	18	1	18204	49	ITGB2
4.738e-02	-3.05	positive regulation of type 2 immune response	biological process	GO:0002830	18	1	18204	49	CD74
4.738e-02	-3.05	tetrahydrofolate metabolic process	biological process	GO:0046653	18	1	18204	49	GCH1
4.738e-02	-3.05	regulation of catecholamine metabolic process	biological process	GO:0042069	18	1	18204	49	ITGB2
4.738e-02	-3.05	regulation of epidermal growth factor-activated receptor activity	biological process	GO:0007176	18	1	18204	49	NCF1
4.738e-02	-3.05	regulation of hydrogen peroxide metabolic process	biological process	GO:0010310	18	1	18204	49	RAC2
4.748e-02	-3.05	SRCR	pfam domains	PF00530	18	1	17795	48	MARCO
4.748e-02	-3.05	Integrin_A_Ig_2	pfam domains	PF20805	18	1	17795	48	ITGAX
4.752e-02	-3.05	Integrin_alpha	interpro domains	IPR000413	18	1	18521	50	ITGAX
4.752e-02	-3.05	Integrin_alpha_Ig-like_2	interpro domains	IPR048285	18	1	18521	50	ITGAX
4.760e-02	-3.04	positive regulation of kinase activity	biological process	GO:0033674	302	3	18204	49	CD74,NCF1,CSF1R
4.774e-02	-3.04	RAB26 (RAB26, member RAS oncogene family)	protein interactions	25837	19	1	19454	50	GCH1
4.774e-02	-3.04	CABLES2 (Cdk5 and Abl enzyme substrate 2)	protein interactions	81928	19	1	19454	50	GCH1
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	GCH1
4.774e-02	-3.04	CSF1 (colony stimulating factor 1)	protein interactions	1435	19	1	19454	50	CSF1R
4.774e-02	-3.04	SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2)	protein interactions	9806	19	1	19454	50	SPOCK3
4.786e-02	-3.04	negative regulation of T cell activation	biological process	GO:0050868	130	2	18204	49	CD74,TNFAIP8L2
4.802e-02	-3.04	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	48	CSF1R,HCK
4.822e-02	-3.03	FCGR activation	REACTOME pathways	R-HSA-2029481	13	1	10285	39	HCK
4.822e-02	-3.03	Signal regulatory protein (SIRP) family interactions	REACTOME pathways	R-HSA-391160	13	1	10285	39	FYB1
4.828e-02	-3.03	ATP5PB (ATP synthase peripheral stalk-membrane subunit b)	protein interactions	515	318	3	19454	50	P2RY6,NDUFS2,UNC93B1
4.842e-02	-3.03	TNFRSF10A (TNF receptor superfamily member 10a)	protein interactions	8797	137	2	19454	50	NDUFS2,RAC2
4.842e-02	-3.03	SPINT2 (serine peptidase inhibitor, Kunitz type 2)	protein interactions	10653	137	2	19454	50	CMTM6,CTSB
4.852e-02	-3.03	mesoderm development	biological process	GO:0007498	131	2	18204	49	HCK,ZFP36L1
4.856e-02	-3.03	Signaling events mediated by PTP1B	Pathway Interaction DB	ptp1bpathway	50	2	2226	16	CSF1R,HCK
4.871e-02	-3.02	RPN1 (ribophorin I)	protein interactions	6184	778	5	19454	50	SMPD4,P2RY6,UNC93B1,CTSB,RAC2
4.881e-02	-3.02	cytoskeleton organization	biological process	GO:0007010	1251	7	18204	49	RAC2,PREX1,MYO1F,GAS7,ELMO1,NCKAP1L,PLEK
4.905e-02	-3.01	AKAP12 (A-kinase anchoring protein 12)	protein interactions	9590	138	2	19454	50	HCK,RAC2
4.905e-02	-3.01	ZW10 (zw10 kinetochore protein)	protein interactions	9183	138	2	19454	50	UNC93B1,RAC2
4.918e-02	-3.01	regulation of mRNA processing	biological process	GO:0050684	132	2	18204	49	RBM47,ZFP36L1
4.937e-02	-3.01	positive regulation of cellular component biogenesis	biological process	GO:0044089	515	4	18204	49	PLEK,NCKAP1L,RAC2,HCK
4.943e-02	-3.01	regulation of phosphorylation	biological process	GO:0042325	994	6	18204	49	ITGB2,NCKAP1L,CSF1R,MARCO,NCF1,CD74
4.966e-02	-3.00	regulation of vesicle-mediated transport	biological process	GO:0060627	516	4	18204	49	NCKAP1L,ITGB2,HCK,RAC2
4.968e-02	-3.00	MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking)	protein interactions	23041	139	2	19454	50	UNC93B1,P2RY6
4.974e-02	-3.00	nucleotide binding	molecular function	GO:0000166	2128	10	18094	48	QSOX1,ITM2B,GCH1,MYO1F,RAC2,ENTPD1,MYO9B,CSF1R,HCK,NDUFS2
4.988e-02	-3.00	nucleoside phosphate binding	molecular function	GO:1901265	2129	10	18094	48	QSOX1,ITM2B,GCH1,RAC2,MYO1F,ENTPD1,CSF1R,MYO9B,NDUFS2,HCK
4.991e-02	-3.00	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	33	16828	46	PREX1,HCK,PLXND1,ZNRF2,CPN1,MYO1F,ITGB2,ELMO1,SLCO2B1,GULP1,RAPGEF6,QSOX1,LPP,GAS7,ITGAX,RAC2,ABR,CSF1R,SMPD4,ARHGAP15,WDFY3,NCAM2,GAB1,TFEB,NCKAP1L,MFNG,RBM47,MYO9B,P2RY6,MARCO,SH2B3,RGS19,SPOCK3
4.995e-02	-3.00	positive regulation of macrophage chemotaxis	biological process	GO:0010759	19	1	18204	49	CSF1R
4.995e-02	-3.00	catechol-containing compound biosynthetic process	biological process	GO:0009713	19	1	18204	49	GCH1
4.995e-02	-3.00	3'-UTR-mediated mRNA destabilization	biological process	GO:0061158	19	1	18204	49	ZFP36L1
4.995e-02	-3.00	microvillus organization	biological process	GO:0032528	19	1	18204	49	RAPGEF6
4.995e-02	-3.00	positive regulation of protein depolymerization	biological process	GO:1901881	19	1	18204	49	PLEK
4.995e-02	-3.00	negative regulation of amyloid precursor protein biosynthetic process	biological process	GO:0042985	19	1	18204	49	ITM2B
4.995e-02	-3.00	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	49	PLEK
4.995e-02	-3.00	regulation of B cell apoptotic process	biological process	GO:0002902	19	1	18204	49	CD74
4.995e-02	-3.00	catecholamine biosynthetic process	biological process	GO:0042423	19	1	18204	49	GCH1
4.995e-02	-3.00	sphingomyelin metabolic process	biological process	GO:0006684	19	1	18204	49	SMPD4
4.995e-02	-3.00	neuromuscular process controlling posture	biological process	GO:0050884	19	1	18204	49	GCH1
4.995e-02	-3.00	base conversion or substitution editing	biological process	GO:0016553	19	1	18204	49	RBM47