Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
4.704e-14	-30.69	nucleoside-triphosphatase regulator activity	molecular function	GO:0060589	491	16	18094	47	GIT2,ARHGAP27,AKAP13,DOCK10,DOCK1,TBC1D8,RGS14,GMIP,ELMO1,DOCK8,PREX1,ARHGAP15,ARHGAP33,DOCK2,DENND1B,VAV3
4.704e-14	-30.69	GTPase regulator activity	molecular function	GO:0030695	491	16	18094	47	ELMO1,GMIP,TBC1D8,RGS14,ARHGAP15,ARHGAP33,DOCK8,PREX1,DOCK2,VAV3,DENND1B,GIT2,ARHGAP27,AKAP13,DOCK1,DOCK10
1.909e-13	-29.29	PH-like_dom_sf	interpro domains	IPR011993	431	15	18521	49	ELMO1,PREX1,ARHGAP15,ARHGAP27,DOCK10,IPCEF1,PLCG2,GAB1,VAV3,SKAP1,TBC1D8,AKAP13,CARMIL3,WDFY4,TLN1
3.180e-12	-26.47	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	gene3d domains	2.30.29.30	431	15	14470	47	ARHGAP27,ELMO1,WDFY4,IPCEF1,VAV3,SKAP1,DOCK10,PLCG2,ARHGAP15,PREX1,GAB1,AKAP13,TLN1,CARMIL3,TBC1D8
1.924e-11	-24.67	signal transduction	biological process	GO:0007165	4637	35	18204	49	CD74,HIF1A,SKAP1,SPI1,PIK3R5,DOCK8,BLNK,DOCK10,ARHGAP15,CSF1R,ELMO1,ARHGAP33,STAT6,FYB1,IRF5,ADCY7,GMIP,VAV3,PREX1,IL6R,PRKCD,P2RY6,DOCK1,P2RY2,ARHGAP27,DOCK2,PTPN6,RGS14,AKAP13,GAB1,DENND1B,HCK,APOE,PLCG2,TLN1
2.697e-11	-24.34	regulation of response to stimulus	biological process	GO:0048583	4104	33	18204	49	GSDME,CSF1R,STAT6,ADCY7,FYB1,GMIP,NEK6,SKAP1,SPI1,HIF1A,CD74,BLNK,PIK3R5,DOCK8,ARHGAP15,SBNO2,HCK,DENND1B,RHBDF2,GIT2,APOE,PLCG2,NRK,PREX1,VAV3,PRKCD,P2RY6,IL6R,DOCK2,ARHGAP27,PTPN6,RGS14,AKAP13
3.335e-11	-24.12	cell activation	biological process	GO:0001775	725	16	18204	49	DOCK8,DOCK10,DOCK2,BLNK,PTPN6,PREX1,VAV3,CD74,IL6R,SPI1,PRKCD,WDFY4,TLN1,PLCG2,STAT6,SBNO2
4.424e-11	-23.84	regulation of intracellular signal transduction	biological process	GO:1902531	1832	23	18204	49	VAV3,PREX1,P2RY6,PRKCD,DOCK2,ARHGAP27,PTPN6,AKAP13,RGS14,GIT2,APOE,PLCG2,NRK,NEK6,SPI1,CD74,HIF1A,PIK3R5,DOCK8,ARHGAP15,CSF1R,GSDME,GMIP
7.844e-11	-23.27	PH_domain	interpro domains	IPR001849	266	11	18521	49	GAB1,VAV3,SKAP1,PLCG2,ARHGAP15,ARHGAP27,DOCK10,IPCEF1,ELMO1,AKAP13,PREX1
8.123e-11	-23.23	GTPase activator activity	molecular function	GO:0005096	273	11	18094	47	DOCK1,DOCK2,VAV3,GMIP,TBC1D8,GIT2,ARHGAP27,RGS14,ARHGAP15,ARHGAP33,PREX1
9.740e-11	-23.05	SH3 Domains	gene3d domains	2.30.30.40	223	11	14470	47	VAV3,SKAP1,MYO1F,DOCK2,PLCG2,ARHGAP27,ELMO1,HCK,ARHGAP33,FYB1,DOCK1
1.556e-10	-22.58	signaling	biological process	GO:0023052	4968	35	18204	49	PIK3R5,DOCK8,BLNK,DOCK10,ARHGAP15,CD74,HIF1A,SPI1,SKAP1,FYB1,IRF5,ADCY7,GMIP,CSF1R,ARHGAP33,ELMO1,STAT6,ARHGAP27,DOCK2,AKAP13,RGS14,PTPN6,VAV3,PREX1,IL6R,PRKCD,P2RY6,P2RY2,DOCK1,APOE,PLCG2,TLN1,GAB1,DENND1B,HCK
1.703e-10	-22.49	regulation of immune system process	biological process	GO:0002682	1584	21	18204	49	BLNK,DOCK8,PTPN6,VAV3,SPI1,SKAP1,PRKCD,HIF1A,CD74,IL6R,RHBDF2,ADCY7,IRF5,FYB1,APOE,PLCG2,CSF1R,GSDME,HCK,STAT6,DENND1B
1.739e-10	-22.47	SH3-like_dom_sf	interpro domains	IPR036028	212	10	18521	49	DOCK1,SKAP1,VAV3,FYB1,PLCG2,ARHGAP33,HCK,DOCK2,MYO1F,ARHGAP27
1.756e-10	-22.46	enzyme regulator activity	molecular function	GO:0030234	1305	19	18094	47	VAV3,DENND1B,DOCK2,PRKCD,ARHGAP15,ARHGAP33,PREX1,DOCK8,ELMO1,GMIP,TBC1D8,RGS14,PIK3R5,APOE,DOCK1,DOCK10,AKAP13,GIT2,ARHGAP27
2.005e-10	-22.33	cell communication	biological process	GO:0007154	5010	35	18204	49	DOCK8,PIK3R5,BLNK,DOCK10,ARHGAP15,CD74,HIF1A,SPI1,SKAP1,FYB1,IRF5,ADCY7,GMIP,CSF1R,ELMO1,ARHGAP33,STAT6,ARHGAP27,DOCK2,PTPN6,AKAP13,RGS14,VAV3,PREX1,IL6R,PRKCD,P2RY6,DOCK1,P2RY2,APOE,TLN1,PLCG2,GAB1,DENND1B,HCK
2.380e-10	-22.16	enzyme binding	molecular function	GO:0019899	2086	23	18094	47	PRKCD,CSF1R,PTPN6,RGS14,SKAP1,HIF1A,PREX1,NEK6,DOCK10,GIT2,IL6R,BLNK,DOCK2,DENND1B,IRF5,ARHGAP33,PLCG2,DOCK1,APOE,SPI1,CD74,STAT6,AKAP13
2.385e-10	-22.16	immune system process	biological process	GO:0002376	1991	23	18204	49	IL6R,PRKCD,PREX1,VAV3,PTPN6,DOCK2,HCK,DENND1B,SBNO2,PLCG2,HIF1A,CD74,SKAP1,SPI1,PIK3R5,DOCK8,DOCK10,BLNK,STAT6,CSF1R,WDFY4,FYB1,IRF5
2.527e-10	-22.10	lymphocyte activation	biological process	GO:0046649	476	13	18204	49	PREX1,PRKCD,SPI1,IL6R,CD74,BLNK,DOCK2,DOCK10,DOCK8,PTPN6,STAT6,WDFY4,PLCG2
2.731e-10	-22.02	SH3_domain	interpro domains	IPR001452	222	10	18521	49	DOCK1,SKAP1,VAV3,FYB1,PLCG2,ARHGAP33,HCK,DOCK2,MYO1F,ARHGAP27
3.257e-10	-21.85	positive regulation of immune system process	biological process	GO:0002684	986	17	18204	49	STAT6,HCK,DENND1B,CSF1R,GSDME,PLCG2,FYB1,IRF5,IL6R,CD74,SPI1,SKAP1,PRKCD,VAV3,PTPN6,DOCK8,BLNK
3.502e-10	-21.77	leukocyte activation	biological process	GO:0045321	599	14	18204	49	IL6R,CD74,SPI1,PRKCD,PREX1,PTPN6,DOCK8,DOCK2,DOCK10,BLNK,STAT6,SBNO2,PLCG2,WDFY4
9.670e-10	-20.76	cellular response to stimulus	biological process	GO:0051716	6307	38	18204	49	SPI1,SKAP1,HIF1A,CD74,IPCEF1,DOCK10,BLNK,PIK3R5,DOCK8,ARHGAP15,ELMO1,ARHGAP33,GSDME,CSF1R,STAT6,ADCY7,IRF5,FYB1,GMIP,PREX1,VAV3,DOCK1,P2RY2,PRKCD,P2RY6,IL6R,DOCK2,ARHGAP27,AKAP13,RGS14,PTPN6,GAB1,SBNO2,HCK,DENND1B,APOE,TLN1,PLCG2
1.604e-09	-20.25	regulation of immune response	biological process	GO:0050776	944	16	18204	49	RHBDF2,ADCY7,FYB1,APOE,PLCG2,GSDME,HCK,STAT6,DENND1B,BLNK,PTPN6,VAV3,SPI1,SKAP1,PRKCD,CD74
2.520e-09	-19.80	enzyme activator activity	molecular function	GO:0008047	599	13	18094	47	DOCK2,PRKCD,VAV3,GMIP,TBC1D8,RGS14,ARHGAP33,ARHGAP15,PREX1,DOCK1,APOE,GIT2,ARHGAP27
3.052e-09	-19.61	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	13	19454	49	STAT6,PRKCD,DOCK1,IL6R,HCK,CSF1R,P2RY2,GAB1,HIF1A,SKAP1,TLN1,FYB1,PTPN6
4.072e-09	-19.32	intracellular signal transduction	biological process	GO:0035556	1505	19	18204	49	PLCG2,GMIP,ADCY7,APOE,HCK,ARHGAP33,ELMO1,AKAP13,PTPN6,BLNK,DOCK2,DOCK10,DOCK8,PIK3R5,PRKCD,DOCK1,HIF1A,VAV3,PREX1
4.383e-09	-19.25	LCP2 (lymphocyte cytosolic protein 2)	protein interactions	3937	54	6	19454	49	FYB1,PTPN6,HCK,VAV3,PLCG2,BLNK
4.748e-09	-19.17	SH3	prosite domains	PS50002	222	10	12186	44	ARHGAP27,DOCK1,PLCG2,HCK,MYO1F,FYB1,SKAP1,DOCK2,VAV3,ARHGAP33
5.183e-09	-19.08	immune effector process	biological process	GO:0002252	389	11	18204	49	DOCK10,DOCK2,PTPN6,VAV3,PRKCD,CD74,IL6R,PLCG2,SBNO2,HCK,STAT6
6.149e-09	-18.91	guanyl-nucleotide exchange factor activity	molecular function	GO:0005085	228	9	18094	47	PREX1,DOCK8,AKAP13,ELMO1,DENND1B,VAV3,DOCK2,DOCK10,DOCK1
7.159e-09	-18.75	regulation of small GTPase mediated signal transduction	biological process	GO:0051056	306	10	18204	49	DOCK2,GIT2,DOCK8,ARHGAP27,APOE,AKAP13,GMIP,ARHGAP15,PREX1,VAV3
8.611e-09	-18.57	immune response-activating cell surface receptor signaling pathway	biological process	GO:0002429	228	9	18204	49	BLNK,FYB1,PLCG2,PTPN6,VAV3,SKAP1,PRKCD,HCK,DENND1B
9.091e-09	-18.52	positive regulation of immune response	biological process	GO:0050778	640	13	18204	49	BLNK,PTPN6,VAV3,CD74,PRKCD,SPI1,SKAP1,FYB1,PLCG2,GSDME,DENND1B,STAT6,HCK
1.117e-08	-18.31	cell surface receptor signaling pathway	biological process	GO:0007166	1992	21	18204	49	SPI1,DOCK1,SKAP1,P2RY2,P2RY6,PRKCD,CD74,IL6R,VAV3,RGS14,PTPN6,BLNK,STAT6,HCK,DENND1B,CSF1R,GAB1,TLN1,PLCG2,IRF5,FYB1
1.272e-08	-18.18	PH_DOMAIN	prosite domains	PS50003	246	10	12186	44	VAV3,IPCEF1,SKAP1,AKAP13,GAB1,PLCG2,DOCK10,PREX1,ARHGAP27,ARHGAP15
1.295e-08	-18.16	leukocyte differentiation	biological process	GO:0002521	425	11	18204	49	BLNK,DOCK10,DOCK2,PLCG2,PREX1,CSF1R,SBNO2,SPI1,IL6R,CD74,STAT6
1.407e-08	-18.08	C2_DOCK-type_domain	interpro domains	IPR027007	11	4	18521	49	DOCK1,DOCK10,DOCK8,DOCK2
1.407e-08	-18.08	DOCKER_dom	interpro domains	IPR027357	11	4	18521	49	DOCK2,DOCK8,DOCK10,DOCK1
1.407e-08	-18.08	DOCK_C_lobe_C	interpro domains	IPR043162	11	4	18521	49	DOCK2,DOCK1,DOCK10,DOCK8
1.407e-08	-18.08	DOCK	interpro domains	IPR026791	11	4	18521	49	DOCK1,DOCK10,DOCK8,DOCK2
1.407e-08	-18.08	DOCKER_Lobe_B	interpro domains	IPR046770	11	4	18521	49	DOCK2,DOCK1,DOCK10,DOCK8
1.407e-08	-18.08	DOCKER_Lobe_C	interpro domains	IPR046773	11	4	18521	49	DOCK1,DOCK8,DOCK10,DOCK2
1.407e-08	-18.08	DOCKER_Lobe_A	interpro domains	IPR046769	11	4	18521	49	DOCK2,DOCK8,DOCK10,DOCK1
1.407e-08	-18.08	DOCK_C_lobe_A	interpro domains	IPR043161	11	4	18521	49	DOCK10,DOCK8,DOCK1,DOCK2
1.650e-08	-17.92	DOCK-C2	pfam domains	PF14429	11	4	17795	49	DOCK10,DOCK8,DOCK2,DOCK1
1.650e-08	-17.92	DHR-2_Lobe_C	pfam domains	PF20421	11	4	17795	49	DOCK2,DOCK1,DOCK8,DOCK10
1.650e-08	-17.92	DHR-2_Lobe_B	pfam domains	PF20422	11	4	17795	49	DOCK2,DOCK1,DOCK8,DOCK10
1.650e-08	-17.92	DHR-2_Lobe_A	pfam domains	PF06920	11	4	17795	49	DOCK10,DOCK2,DOCK1,DOCK8
1.910e-08	-17.77	positive regulation of response to stimulus	biological process	GO:0048584	2266	22	18204	49	AKAP13,PTPN6,PIK3R5,BLNK,HIF1A,CD74,IL6R,SPI1,SKAP1,P2RY6,PRKCD,NEK6,VAV3,NRK,PLCG2,FYB1,APOE,HCK,STAT6,DENND1B,GSDME,CSF1R
2.144e-08	-17.66	hemopoiesis	biological process	GO:0030097	688	13	18204	49	CSF1R,STAT6,SBNO2,PLCG2,PREX1,CD74,IL6R,HIF1A,SPI1,BLNK,DOCK2,DOCK10,PTPN6
2.871e-08	-17.37	immune response-regulating cell surface receptor signaling pathway	biological process	GO:0002768	262	9	18204	49	SKAP1,PRKCD,HCK,DENND1B,VAV3,PTPN6,PLCG2,BLNK,FYB1
2.934e-08	-17.34	response to stimulus	biological process	GO:0050896	7803	40	18204	49	CSF1R,GSDME,ARHGAP33,ELMO1,STAT6,WDFY4,FYB1,ADCY7,IRF5,GMIP,HIF1A,CD74,SKAP1,SPI1,DOCK8,PIK3R5,DOCK10,IPCEF1,BLNK,ARHGAP15,GAB1,HCK,DENND1B,SBNO2,APOE,TLN1,PLCG2,PREX1,VAV3,IL6R,DOCK1,P2RY2,P2RY6,PRKCD,ARHGAP27,TBXAS1,DOCK2,PTPN6,AKAP13,RGS14
3.170e-08	-17.27	-	gene3d domains	1.25.40.410	11	4	14470	47	DOCK2,DOCK1,DOCK10,DOCK8
3.170e-08	-17.27	-	gene3d domains	1.20.58.740	11	4	14470	47	DOCK8,DOCK10,DOCK1,DOCK2
3.710e-08	-17.11	mononuclear cell differentiation	biological process	GO:1903131	364	10	18204	49	PLCG2,BLNK,DOCK10,DOCK2,CD74,IL6R,STAT6,SPI1,CSF1R,PREX1
4.015e-08	-17.03	positive regulation of catalytic activity	biological process	GO:0043085	868	14	18204	49	GMIP,APOE,TBC1D8,CSF1R,DOCK10,PIK3R5,DOCK8,ARHGAP27,PRKCD,P2RY6,HIF1A,CD74,IL6R,PREX1
4.789e-08	-16.85	DOCKER	prosite domains	PS51651	11	4	12186	44	DOCK2,DOCK10,DOCK1,DOCK8
4.789e-08	-16.85	C2_DOCK	prosite domains	PS51650	11	4	12186	44	DOCK10,DOCK2,DOCK8,DOCK1
4.896e-08	-16.83	PH	smart domains	SM00233	259	10	9717	39	PREX1,ARHGAP15,AKAP13,VAV3,SKAP1,ARHGAP27,GAB1,IPCEF1,DOCK10,PLCG2
5.961e-08	-16.64	cellular response to chemical stimulus	biological process	GO:0070887	2411	22	18204	49	HCK,SBNO2,GAB1,PLCG2,APOE,IL6R,PRKCD,P2RY6,P2RY2,VAV3,PREX1,PTPN6,STAT6,GSDME,CSF1R,IRF5,ADCY7,CD74,HIF1A,SPI1,DOCK8,IPCEF1
6.027e-08	-16.62	regulation of catalytic activity	biological process	GO:0050790	1395	17	18204	49	ARHGAP27,DOCK8,PIK3R5,DOCK10,ARHGAP15,RGS14,PREX1,VAV3,HIF1A,IL6R,CD74,P2RY6,PRKCD,APOE,GMIP,CSF1R,TBC1D8
6.587e-08	-16.54	molecular function regulator activity	molecular function	GO:0098772	2079	20	18094	47	APOE,PIK3R5,DOCK10,DOCK1,AKAP13,ARHGAP27,GIT2,DENND1B,VAV3,PRKCD,DOCK2,DOCK8,PREX1,ARHGAP33,ARHGAP15,RGS14,TBC1D8,HIF1A,ELMO1,GMIP
6.683e-08	-16.52	endocytosis	biological process	GO:0006897	499	11	18204	49	APOE,ARHGAP27,DOCK2,MYO1F,VAV3,ELMO1,DENND1B,HCK,P2RY6,PRKCD,DOCK1
6.863e-08	-16.49	lymphocyte differentiation	biological process	GO:0030098	290	9	18204	49	PREX1,CD74,IL6R,STAT6,SPI1,BLNK,DOCK2,DOCK10,PLCG2
7.362e-08	-16.42	BLNK (B cell linker)	protein interactions	29760	43	5	19454	49	GAB1,PTPN6,PLCG2,TLN1,VAV3
7.494e-08	-16.41	SH3	smart domains	SM00326	202	9	9717	39	ARHGAP33,PLCG2,HCK,DOCK1,MYO1F,DOCK2,VAV3,FYB1,SKAP1
7.515e-08	-16.40	regulation of molecular function	biological process	GO:0065009	2005	20	18204	49	PLCG2,GMIP,APOE,TBC1D8,HCK,CSF1R,RGS14,ARHGAP15,DOCK10,DOCK8,PIK3R5,ARHGAP27,SPI1,PRKCD,P2RY6,HIF1A,CD74,IL6R,PREX1,VAV3
8.546e-08	-16.28	antigen receptor-mediated signaling pathway	biological process	GO:0050851	139	7	18204	49	FYB1,BLNK,PTPN6,PLCG2,VAV3,DENND1B,SKAP1
9.700e-08	-16.15	immune response-activating signaling pathway	biological process	GO:0002757	302	9	18204	49	SKAP1,PRKCD,HCK,DENND1B,VAV3,PTPN6,PLCG2,BLNK,FYB1
1.388e-07	-15.79	T cell activation	biological process	GO:0042110	315	9	18204	49	DOCK2,WDFY4,DOCK8,PTPN6,PREX1,SPI1,IL6R,CD74,STAT6
1.437e-07	-15.76	plasma membrane	cellular component	GO:0005886	5538	32	19108	49	ADCY7,GMIP,HCK,MYO1F,CARMIL3,PRKCD,ELMO1,PLCG2,PTPN6,BLNK,DOCK8,P2RY6,CSF1R,APOE,PIK3R5,VAV3,DOCK2,PARVG,ARHGAP33,PREX1,TLN1,DOCK1,RHBDF2,FYB1,IL6R,SKAP1,GSDME,IPCEF1,P2RY2,ARHGAP15,RGS14,CD74
1.457e-07	-15.74	regulation of MAPK cascade	biological process	GO:0043408	669	12	18204	49	P2RY6,PRKCD,SPI1,CD74,PIK3R5,RGS14,PTPN6,CSF1R,GSDME,APOE,PLCG2,NRK
2.107e-07	-15.37	cellular response to organic substance	biological process	GO:0071310	1716	18	18204	49	DOCK8,PTPN6,PRKCD,P2RY6,P2RY2,SPI1,CD74,IL6R,HIF1A,IRF5,ADCY7,PLCG2,GAB1,GSDME,CSF1R,SBNO2,STAT6,HCK
2.432e-07	-15.23	immune response	biological process	GO:0006955	1349	16	18204	49	FYB1,IRF5,PLCG2,CSF1R,STAT6,HCK,SBNO2,PIK3R5,DOCK2,DOCK10,BLNK,PTPN6,CD74,IL6R,SKAP1,PRKCD
2.687e-07	-15.13	cell periphery	cellular component	GO:0071944	6020	33	19108	49	MYO1F,HCK,ADCY7,GMIP,CARMIL3,PRKCD,ELMO1,AKAP13,PLCG2,PTPN6,DOCK8,BLNK,CSF1R,P2RY6,APOE,VAV3,PIK3R5,PARVG,DOCK2,ARHGAP33,PREX1,DOCK1,RHBDF2,TLN1,FYB1,IL6R,SKAP1,GSDME,ARHGAP15,P2RY2,IPCEF1,CD74,RGS14
2.741e-07	-15.11	regulation of signal transduction	biological process	GO:0009966	3114	24	18204	49	ARHGAP27,DOCK2,AKAP13,RGS14,PTPN6,PREX1,VAV3,P2RY6,PRKCD,APOE,RHBDF2,GIT2,NRK,PLCG2,DOCK8,PIK3R5,ARHGAP15,NEK6,HIF1A,CD74,SPI1,GMIP,CSF1R,GSDME
3.038e-07	-15.01	positive regulation of molecular function	biological process	GO:0044093	1192	15	18204	49	DOCK10,DOCK8,PIK3R5,ARHGAP27,PREX1,PRKCD,P2RY6,IL6R,CD74,HIF1A,APOE,PLCG2,GMIP,CSF1R,TBC1D8
3.113e-07	-14.98	SH2	pfam domains	PF00017	100	6	17795	49	VAV3,BLNK,PLCG2,HCK,STAT6,PTPN6
3.268e-07	-14.93	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	6	19454	49	HCK,BLNK,PTPN6,CSF1R,VAV3,PLCG2
3.829e-07	-14.78	Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME pathways	R-HSA-2029480	86	6	10285	35	ELMO1,HCK,PRKCD,DOCK1,VAV3,PLCG2
3.945e-07	-14.75	cellular response to cytokine stimulus	biological process	GO:0071345	734	12	18204	49	CSF1R,GSDME,HCK,STAT6,SBNO2,IRF5,HIF1A,CD74,IL6R,SPI1,DOCK8,PTPN6
4.014e-07	-14.73	Rho GTPase cycle	REACTOME pathways	R-HSA-194840	142	7	10285	35	ARHGAP27,VAV3,GMIP,PREX1,ARHGAP33,AKAP13,ARHGAP15
4.117e-07	-14.70	SH2	interpro domains	IPR000980	109	6	18521	49	PLCG2,PTPN6,VAV3,HCK,STAT6,BLNK
4.880e-07	-14.53	cytosol	cellular component	GO:0005829	5475	31	19108	49	GSDME,SKAP1,FYB1,IRF5,ARHGAP15,DOCK2,NEK6,DOCK1,TLN1,PREX1,ARHGAP33,BLNK,DOCK8,VAV3,ARHGAP27,PIK3R5,NRK,ELMO1,STAT6,DOCK10,PRKCD,HCK,MYO1F,GMIP,TBXAS1,PTPN6,GAB1,DENND1B,HIF1A,PLCG2,AKAP13
5.096e-07	-14.49	SH2_dom_sf	interpro domains	IPR036860	113	6	18521	49	HCK,PTPN6,VAV3,BLNK,STAT6,PLCG2
5.146e-07	-14.48	immune response-regulating signaling pathway	biological process	GO:0002764	368	9	18204	49	HCK,DENND1B,SKAP1,PRKCD,VAV3,PTPN6,PLCG2,FYB1,BLNK
5.146e-07	-14.48	activation of immune response	biological process	GO:0002253	368	9	18204	49	FYB1,BLNK,PTPN6,PLCG2,VAV3,HCK,DENND1B,SKAP1,PRKCD
6.317e-07	-14.27	molecular function activator activity	molecular function	GO:0140677	1132	14	18094	47	ARHGAP27,GIT2,APOE,DOCK1,PREX1,ARHGAP15,ARHGAP33,TBC1D8,RGS14,GMIP,HIF1A,VAV3,DOCK2,PRKCD
7.012e-07	-14.17	regulation of GTPase activity	biological process	GO:0043087	278	8	18204	49	ARHGAP27,DOCK8,DOCK10,ARHGAP15,GMIP,VAV3,PREX1,TBC1D8
7.440e-07	-14.11	VAV1 (vav guanine nucleotide exchange factor 1)	protein interactions	7409	204	7	19454	49	PTPN6,HCK,PLCG2,GAB1,BLNK,DOCK2,SPI1
7.483e-07	-14.11	PH	pfam domains	PF00169	187	7	17795	49	GAB1,IPCEF1,DOCK10,SKAP1,VAV3,ARHGAP15,ARHGAP27
7.987e-07	-14.04	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	13	19454	49	GAB1,GIT2,PREX1,ARHGAP27,DOCK8,PRKCD,VAV3,ARHGAP15,DOCK1,DOCK2,ARHGAP33,GMIP,EHBP1L1
9.515e-07	-13.87	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	17	18204	49	IRF5,APOE,PLCG2,CSF1R,GAB1,STAT6,DENND1B,TBXAS1,DOCK8,RGS14,PTPN6,VAV3,P2RY2,SPI1,HIF1A,IL6R,CD74
1.045e-06	-13.77	leukocyte activation involved in immune response	biological process	GO:0002366	201	7	18204	49	DOCK10,DOCK2,PLCG2,STAT6,CD74,IL6R,SBNO2
1.193e-06	-13.64	cell activation involved in immune response	biological process	GO:0002263	205	7	18204	49	SBNO2,CD74,IL6R,STAT6,PLCG2,DOCK10,DOCK2
1.478e-06	-13.42	SH2 domain	gene3d domains	3.30.505.10	111	6	14470	47	PTPN6,STAT6,PLCG2,VAV3,BLNK,HCK
1.522e-06	-13.40	response to cytokine	biological process	GO:0034097	834	12	18204	49	HIF1A,IL6R,CD74,SPI1,PTPN6,DOCK8,HCK,STAT6,SBNO2,GSDME,CSF1R,IRF5
1.580e-06	-13.36	intracellular signaling cassette	biological process	GO:0141124	837	12	18204	49	VAV3,DOCK1,DOCK10,DOCK2,PIK3R5,DOCK8,AKAP13,PTPN6,ELMO1,ARHGAP33,APOE,PLCG2
1.606e-06	-13.34	import into cell	biological process	GO:0098657	687	11	18204	49	DOCK1,P2RY6,PRKCD,HCK,DENND1B,ELMO1,VAV3,MYO1F,DOCK2,ARHGAP27,APOE
1.970e-06	-13.14	Signal Transduction	REACTOME pathways	R-HSA-162582	2547	22	10285	35	AKAP13,STAT6,ADCY7,PREX1,ELMO1,DOCK1,APOE,TLN1,GAB1,VAV3,PIK3R5,IL6R,ARHGAP15,RGS14,ARHGAP27,PTPN6,PRKCD,P2RY2,ARHGAP33,GMIP,P2RY6,HIF1A
1.998e-06	-13.12	Nef and signal transduction	REACTOME pathways	R-HSA-164944	8	3	10285	35	ELMO1,HCK,DOCK2
2.024e-06	-13.11	positive T cell selection	biological process	GO:0043368	34	4	18204	49	DOCK2,STAT6,IL6R,CD74
2.126e-06	-13.06	response to chemical	biological process	GO:0042221	3743	25	18204	49	DOCK2,TBXAS1,PTPN6,VAV3,PREX1,IL6R,PRKCD,P2RY6,P2RY2,APOE,PLCG2,GAB1,HCK,SBNO2,DOCK8,IPCEF1,CD74,HIF1A,SPI1,IRF5,ADCY7,CSF1R,GSDME,ARHGAP33,STAT6
2.143e-06	-13.05	SH2	prosite domains	PS50001	107	6	12186	44	PTPN6,BLNK,VAV3,STAT6,HCK,PLCG2
2.601e-06	-12.86	PLCG2 (phospholipase C gamma 2)	protein interactions	5336	87	5	19454	49	PLCG2,GAB1,HCK,PTPN6,BLNK
2.670e-06	-12.83	positive regulation of intracellular signal transduction	biological process	GO:1902533	1048	13	18204	49	CD74,SPI1,P2RY6,NEK6,VAV3,PTPN6,AKAP13,PIK3R5,GSDME,CSF1R,NRK,PLCG2,APOE
2.971e-06	-12.73	regulation of signaling	biological process	GO:0023051	3534	24	18204	49	GMIP,CSF1R,GSDME,ARHGAP15,DOCK8,PIK3R5,SPI1,CD74,HIF1A,NEK6,PLCG2,NRK,GIT2,RHBDF2,APOE,RGS14,PTPN6,AKAP13,DOCK2,ARHGAP27,P2RY6,PRKCD,VAV3,PREX1
3.010e-06	-12.71	SH2	smart domains	SM00252	103	6	9717	39	BLNK,VAV3,STAT6,PTPN6,PLCG2,HCK
3.081e-06	-12.69	regulation of cell communication	biological process	GO:0010646	3541	24	18204	49	RHBDF2,GIT2,APOE,PLCG2,NRK,PREX1,VAV3,P2RY6,PRKCD,DOCK2,ARHGAP27,RGS14,AKAP13,PTPN6,CSF1R,GSDME,GMIP,NEK6,SPI1,HIF1A,CD74,PIK3R5,DOCK8,ARHGAP15
3.209e-06	-12.65	positive regulation of cell migration	biological process	GO:0030335	592	10	18204	49	HIF1A,CD74,IL6R,DOCK1,P2RY6,CSF1R,GAB1,PREX1,PLCG2,DOCK8
3.249e-06	-12.64	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	5	19454	49	CSF1R,GAB1,HCK,PTPN6,PRKCD
3.296e-06	-12.62	positive regulation of biological process	biological process	GO:0048518	6326	33	18204	49	PLCG2,NRK,APOE,SBNO2,TBC1D8,DENND1B,HCK,GAB1,AKAP13,RGS14,PTPN6,DOCK2,TBXAS1,PRKCD,P2RY6,P2RY2,DOCK1,IL6R,VAV3,PREX1,IRF5,FYB1,STAT6,GSDME,CSF1R,BLNK,DOCK8,PIK3R5,SKAP1,SPI1,CD74,HIF1A,NEK6
3.552e-06	-12.55	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	7	19454	49	PLCG2,TLN1,VAV3,HCK,PTPN6,GAB1,BLNK
4.081e-06	-12.41	positive regulation of MAPK cascade	biological process	GO:0043410	473	9	18204	49	P2RY6,SPI1,CD74,GSDME,CSF1R,PLCG2,NRK,APOE,PIK3R5
4.141e-06	-12.39	phagocytosis	biological process	GO:0006909	159	6	18204	49	HCK,P2RY6,PRKCD,DOCK1,VAV3,ELMO1
4.431e-06	-12.33	regulation of body fluid levels	biological process	GO:0050878	356	8	18204	49	APOE,PTPN6,TLN1,PLCG2,VAV3,PRKCD,P2RY2,HIF1A
4.641e-06	-12.28	Hemostasis	REACTOME pathways	R-HSA-109582	632	11	10285	35	DOCK8,DOCK1,PRKCD,PTPN6,DOCK2,CD74,PLCG2,DOCK10,PIK3R5,VAV3,TLN1
4.764e-06	-12.25	SH3DOMAIN	prints domains	PR00452	83	5	5227	17	MYO1F,HCK,PLCG2,VAV3,SKAP1
4.767e-06	-12.25	positive regulation of cell motility	biological process	GO:2000147	619	10	18204	49	CSF1R,GAB1,PREX1,HIF1A,CD74,IL6R,DOCK1,P2RY6,DOCK8,PLCG2
5.473e-06	-12.12	small GTPase-mediated signal transduction	biological process	GO:0007264	258	7	18204	49	VAV3,ELMO1,ARHGAP33,DOCK1,DOCK2,DOCK10,DOCK8
5.710e-06	-12.07	C2_domain_sf	interpro domains	IPR035892	171	6	18521	49	DOCK2,DOCK8,DOCK10,PRKCD,PLCG2,DOCK1
5.807e-06	-12.06	positive regulation of locomotion	biological process	GO:0040017	633	10	18204	49	PLCG2,DOCK8,DOCK1,P2RY6,HIF1A,IL6R,CD74,PREX1,CSF1R,GAB1
5.810e-06	-12.06	B cell receptor signaling pathway	biological process	GO:0050853	44	4	18204	49	PLCG2,PTPN6,VAV3,BLNK
5.827e-06	-12.05	integrin-mediated signaling pathway	biological process	GO:0007229	96	5	18204	49	FYB1,VAV3,HCK,DOCK1,TLN1
5.904e-06	-12.04	positive regulation of immune effector process	biological process	GO:0002699	261	7	18204	49	SPI1,DENND1B,CD74,STAT6,IRF5,PTPN6,PLCG2
6.324e-06	-11.97	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	31	16828	45	P2RY2,GAB1,ARHGAP15,RGS14,BLNK,IPCEF1,ELMO1,GMIP,PREX1,PARVG,ARHGAP27,TBXAS1,ADCY7,DOCK2,HCK,TLN1,DOCK8,DOCK1,EHBP1L1,VAV3,HIF1A,IRF5,AKAP13,DOCK10,MYO1F,P2RY6,PLCG2,PRKCD,CSF1R,RHBDF2,TBC1D8
7.576e-06	-11.79	Chemokine signaling pathway	KEGG pathways	hsa04062	182	7	7161	30	ELMO1,HCK,VAV3,PREX1,ADCY7,DOCK2,PRKCD
7.576e-06	-11.79	Chemokine signaling pathway	KEGG pathways	ko04062	182	7	7161	30	PRKCD,ADCY7,DOCK2,VAV3,PREX1,ELMO1,HCK
7.588e-06	-11.79	T cell selection	biological process	GO:0045058	47	4	18204	49	DOCK2,STAT6,IL6R,CD74
7.717e-06	-11.77	cytokine-mediated signaling pathway	biological process	GO:0019221	384	8	18204	49	IRF5,PTPN6,CSF1R,CD74,IL6R,STAT6,HCK,SPI1
9.000e-06	-11.62	T cell differentiation	biological process	GO:0030217	182	6	18204	49	DOCK2,PREX1,SPI1,STAT6,IL6R,CD74
9.873e-06	-11.53	Immune System	REACTOME pathways	R-HSA-168256	2101	19	10285	35	FYB1,DOCK1,PRKCD,PTPN6,DOCK2,ELMO1,BLNK,HIF1A,PLCG2,GAB1,VAV3,TLN1,HCK,CSF1R,STAT6,ADCY7,IL6R,IRF5,CD74
9.913e-06	-11.52	T cell receptor signaling pathway	biological process	GO:0050852	107	5	18204	49	FYB1,PTPN6,SKAP1,PLCG2,DENND1B
1.009e-05	-11.50	protein kinase binding	molecular function	GO:0019901	701	10	18094	47	PLCG2,BLNK,NEK6,PRKCD,ARHGAP33,HIF1A,SKAP1,PTPN6,RGS14,IRF5
1.036e-05	-11.48	positive regulation of cell communication	biological process	GO:0010647	1792	16	18204	49	AKAP13,RGS14,PTPN6,PIK3R5,SPI1,PRKCD,P2RY6,HIF1A,CD74,NEK6,VAV3,PLCG2,NRK,APOE,GSDME,CSF1R
1.051e-05	-11.46	positive regulation of signaling	biological process	GO:0023056	1794	16	18204	49	GSDME,CSF1R,PLCG2,NRK,APOE,PRKCD,P2RY6,SPI1,CD74,HIF1A,VAV3,NEK6,RGS14,AKAP13,PTPN6,PIK3R5
1.063e-05	-11.45	C2 domain	gene3d domains	2.60.40.150	156	6	14470	47	DOCK8,PRKCD,DOCK2,PLCG2,DOCK1,DOCK10
1.139e-05	-11.38	positive regulation of signal transduction	biological process	GO:0009967	1593	15	18204	49	GSDME,CSF1R,APOE,PLCG2,NRK,NEK6,VAV3,SPI1,PRKCD,P2RY6,HIF1A,CD74,PIK3R5,AKAP13,PTPN6
1.159e-05	-11.37	response to organic substance	biological process	GO:0010033	2498	19	18204	49	CD74,IL6R,HIF1A,P2RY6,PRKCD,P2RY2,SPI1,PTPN6,DOCK8,TBXAS1,HCK,STAT6,SBNO2,GAB1,GSDME,CSF1R,PLCG2,IRF5,ADCY7
1.428e-05	-11.16	Fc receptor signaling pathway	biological process	GO:0038093	55	4	18204	49	PLCG2,PRKCD,HCK,VAV3
1.437e-05	-11.15	CRKL (CRK like proto-oncogene, adaptor protein)	protein interactions	1399	211	6	19454	49	BLNK,DOCK2,HCK,GAB1,ELMO1,DOCK1
1.570e-05	-11.06	SH3 domain binding	molecular function	GO:0017124	122	5	18094	47	DOCK1,ELMO1,PTPN6,ARHGAP27,SKAP1
1.603e-05	-11.04	positive regulation of cellular process	biological process	GO:0048522	5719	30	18204	49	RGS14,PTPN6,AKAP13,DOCK2,DOCK1,PRKCD,P2RY6,IL6R,PREX1,VAV3,PLCG2,NRK,APOE,TBC1D8,SBNO2,HCK,DENND1B,GAB1,BLNK,PIK3R5,DOCK8,SKAP1,SPI1,HIF1A,CD74,NEK6,IRF5,STAT6,CSF1R,GSDME
1.788e-05	-10.93	regulation of cell migration	biological process	GO:0030334	1061	12	18204	49	DOCK10,DOCK8,APOE,PLCG2,PREX1,CSF1R,GAB1,DOCK1,P2RY6,HIF1A,IL6R,CD74
1.849e-05	-10.90	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	34	16828	45	AKAP13,VAV3,IRF5,HIF1A,DOCK1,EHBP1L1,HCK,TLN1,DOCK8,RHBDF2,TBC1D8,CSF1R,P2RY6,PLCG2,PRKCD,DOCK10,MYO1F,DENND1B,IPCEF1,ELMO1,GMIP,RGS14,BLNK,GAB1,ARHGAP33,ARHGAP15,P2RY2,ADCY7,DOCK2,TBXAS1,PTPN6,PARVG,ARHGAP27,PREX1
1.918e-05	-10.86	regulation of hydrolase activity	biological process	GO:0051336	726	10	18204	49	PREX1,VAV3,TBC1D8,P2RY6,PRKCD,DOCK10,ARHGAP27,DOCK8,GMIP,ARHGAP15
1.927e-05	-10.86	response to external stimulus	biological process	GO:0009605	1882	16	18204	49	PREX1,VAV3,PRKCD,HIF1A,IL6R,CD74,DOCK2,PTPN6,CSF1R,GSDME,GAB1,SBNO2,HCK,IRF5,WDFY4,PLCG2
1.978e-05	-10.83	G protein-coupled UTP receptor activity	molecular function	GO:0045030	3	2	18094	47	P2RY2,P2RY6
2.023e-05	-10.81	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	biological process	GO:0002433	20	3	18204	49	PRKCD,HCK,VAV3
2.023e-05	-10.81	Fc-gamma receptor signaling pathway involved in phagocytosis	biological process	GO:0038096	20	3	18204	49	PRKCD,HCK,VAV3
2.084e-05	-10.78	positive regulation of GTPase activity	biological process	GO:0043547	211	6	18204	49	ARHGAP27,DOCK8,DOCK10,PREX1,GMIP,TBC1D8
2.359e-05	-10.65	SH3_2	pfam domains	PF07653	61	4	17795	49	VAV3,FYB1,ARHGAP33,DOCK2
2.365e-05	-10.65	regulation of B cell activation	biological process	GO:0050864	128	5	18204	49	VAV3,CD74,STAT6,PTPN6,SPI1
2.541e-05	-10.58	kinase binding	molecular function	GO:0019900	780	10	18094	47	PRKCD,NEK6,BLNK,PLCG2,ARHGAP33,HIF1A,RGS14,PTPN6,IRF5,SKAP1
2.562e-05	-10.57	membrane	cellular component	GO:0016020	9220	38	19108	49	CD74,RGS14,ARHGAP15,IPCEF1,P2RY2,GSDME,SKAP1,IL6R,FYB1,DOCK1,RHBDF2,TLN1,PREX1,ARHGAP33,PARVG,DOCK2,ARHGAP27,VAV3,TBC1D8,PIK3R5,APOE,CSF1R,P2RY6,DOCK8,BLNK,PTPN6,PLCG2,AKAP13,ELMO1,PRKCD,DOCK10,CARMIL3,MYO1F,HCK,EHBP1L1,ADCY7,TBXAS1,GMIP
2.578e-05	-10.57	SHC1 (SHC adaptor protein 1)	protein interactions	6464	350	7	19454	49	GAB1,HIF1A,PTPN6,CSF1R,PRKCD,VAV3,PLCG2
2.583e-05	-10.56	cell motility	biological process	GO:0048870	1101	12	18204	49	HIF1A,HCK,IL6R,DOCK1,PRKCD,CARMIL3,GAB1,PREX1,ELMO1,VAV3,DOCK8,DOCK2
2.599e-05	-10.56	cell migration	biological process	GO:0016477	921	11	18204	49	DOCK8,DOCK2,CARMIL3,GAB1,PREX1,VAV3,HIF1A,HCK,IL6R,DOCK1,PRKCD
2.600e-05	-10.56	RhoGAP_dom	interpro domains	IPR000198	65	4	18521	49	ARHGAP27,GMIP,ARHGAP15,ARHGAP33
2.637e-05	-10.54	regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050730	220	6	18204	49	CSF1R,PRKCD,CD74,IL6R,PTPN6,PLCG2
2.723e-05	-10.51	Fc receptor mediated stimulatory signaling pathway	biological process	GO:0002431	22	3	18204	49	VAV3,HCK,PRKCD
2.762e-05	-10.50	PE/DAG-bd	interpro domains	IPR002219	66	4	18521	49	AKAP13,PRKCD,VAV3,GMIP
2.882e-05	-10.45	IL6ST (interleukin 6 cytokine family signal transducer)	protein interactions	3572	70	4	19454	49	PRKCD,PTPN6,HCK,IL6R
2.882e-05	-10.45	INPP5D (inositol polyphosphate-5-phosphatase D)	protein interactions	3635	70	4	19454	49	HCK,GAB1,CSF1R,PRKCD
3.036e-05	-10.40	RhoGAP	pfam domains	PF00620	65	4	17795	49	ARHGAP15,ARHGAP27,ARHGAP33,GMIP
3.056e-05	-10.40	positive regulation of production of molecular mediator of immune response	biological process	GO:0002702	135	5	18204	49	PLCG2,STAT6,CD74,DENND1B,IRF5
3.113e-05	-10.38	regulation of cell motility	biological process	GO:2000145	1122	12	18204	49	APOE,DOCK8,DOCK10,PLCG2,GAB1,CSF1R,PREX1,CD74,IL6R,HIF1A,P2RY6,DOCK1
3.115e-05	-10.38	positive regulation of hydrolase activity	biological process	GO:0051345	466	8	18204	49	TBC1D8,P2RY6,PRKCD,PREX1,GMIP,DOCK8,ARHGAP27,DOCK10
3.118e-05	-10.38	Fc gamma R-mediated phagocytosis	KEGG pathways	hsa04666	90	5	7161	30	HCK,DOCK2,PRKCD,PLCG2,VAV3
3.118e-05	-10.38	Fc gamma R-mediated phagocytosis	KEGG pathways	ko04666	90	5	7161	30	PLCG2,PRKCD,VAV3,HCK,DOCK2
3.150e-05	-10.37	GPVI-mediated activation cascade	REACTOME pathways	R-HSA-114604	54	4	10285	35	PLCG2,PIK3R5,VAV3,PTPN6
3.279e-05	-10.33	lymphocyte activation involved in immune response	biological process	GO:0002285	137	5	18204	49	DOCK10,IL6R,CD74,STAT6,PLCG2
3.801e-05	-10.18	NHLRC2 (NHL repeat containing 2)	protein interactions	374354	372	7	19454	49	DOCK10,MYO1F,PRKCD,TBXAS1,TLN1,AKAP13,ARHGAP15
3.949e-05	-10.14	G protein-coupled pyrimidinergic nucleotide receptor activity	molecular function	GO:0071553	4	2	18094	47	P2RY2,P2RY6
4.166e-05	-10.09	positive regulation of chemokine production	biological process	GO:0032722	72	4	18204	49	HIF1A,CD74,IL6R,CSF1R
4.465e-05	-10.02	regulation of locomotion	biological process	GO:0040012	1164	12	18204	49	DOCK10,DOCK8,PREX1,DOCK1,P2RY6,HIF1A,IL6R,CD74,APOE,PLCG2,CSF1R,GAB1
4.727e-05	-9.96	regulation of cell adhesion	biological process	GO:0030155	807	10	18204	49	DOCK8,PTPN6,TLN1,PREX1,VAV3,CD74,DOCK1,SKAP1,SPI1,PRKCD
5.219e-05	-9.86	Regulation of RAC1 activity	Pathway Interaction DB	rac1_reg_pathway	39	5	2226	25	PREX1,DOCK1,ELMO1,VAV3,DOCK2
5.381e-05	-9.83	-	gene3d domains	3.30.60.20	64	4	14470	47	VAV3,AKAP13,PRKCD,GMIP
5.411e-05	-9.82	bone	COSMIC cancer mutations	bone	8157	35	16828	45	PREX1,PARVG,PTPN6,ARHGAP27,TBXAS1,DOCK2,ADCY7,P2RY2,ARHGAP33,GAB1,ARHGAP15,BLNK,RGS14,ELMO1,GMIP,IPCEF1,DENND1B,MYO1F,DOCK10,P2RY6,PRKCD,PLCG2,CSF1R,WDFY4,TBC1D8,RHBDF2,HCK,TLN1,DOCK8,DOCK1,EHBP1L1,IRF5,HIF1A,VAV3,AKAP13
5.442e-05	-9.82	ZF_DAG_PE_1	prosite domains	PS00479	58	4	12186	44	VAV3,AKAP13,PRKCD,GMIP
5.559e-05	-9.80	leukocyte proliferation	biological process	GO:0070661	153	5	18204	49	DOCK2,DOCK8,CSF1R,PTPN6,PRKCD
5.570e-05	-9.80	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	23	16828	45	TBXAS1,CSF1R,GIT2,RHBDF2,DOCK2,PIK3R5,PREX1,MYO1F,PLCG2,PTPN6,BLNK,VAV3,HIF1A,IRF5,IPCEF1,ELMO1,GMIP,AKAP13,DOCK8,TLN1,STAT6,EHBP1L1,DOCK1
5.594e-05	-9.79	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	23	16828	45	DOCK8,TLN1,STAT6,EHBP1L1,DOCK1,BLNK,VAV3,IRF5,HIF1A,IPCEF1,GMIP,ELMO1,AKAP13,PIK3R5,PREX1,MYO1F,PLCG2,PTPN6,CSF1R,TBXAS1,GIT2,RHBDF2,DOCK2
5.913e-05	-9.74	myeloid leukocyte activation	biological process	GO:0002274	155	5	18204	49	PRKCD,SBNO2,PLCG2,PREX1,DOCK2
6.075e-05	-9.71	Rho GTPase activation protein	gene3d domains	1.10.555.10	66	4	14470	47	ARHGAP15,ARHGAP27,GMIP,ARHGAP33
6.257e-05	-9.68	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	9	19454	49	GAB1,BLNK,PLCG2,SKAP1,PRKCD,CSF1R,TBC1D8,HCK,PTPN6
6.307e-05	-9.67	response to biotic stimulus	biological process	GO:0009607	1408	13	18204	49	PTPN6,CD74,IL6R,HIF1A,PRKCD,SPI1,WDFY4,IRF5,PLCG2,GSDME,CSF1R,HCK,SBNO2
6.346e-05	-9.67	GAB1 (GRB2 associated binding protein 1)	protein interactions	2549	168	5	19454	49	GAB1,HCK,BLNK,PLCG2,VAV3
6.375e-05	-9.66	cellular response to interleukin-6	biological process	GO:0071354	29	3	18204	49	SBNO2,SPI1,IL6R
6.450e-05	-9.65	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	23	16828	45	DOCK2,TBXAS1,PTPN6,PREX1,PIK3R5,GMIP,ELMO1,IPCEF1,BLNK,RHBDF2,CSF1R,GIT2,PLCG2,MYO1F,AKAP13,HIF1A,IRF5,VAV3,DOCK1,EHBP1L1,STAT6,TLN1,DOCK8
6.618e-05	-9.62	positive regulation of cytokine production involved in immune response	biological process	GO:0002720	81	4	18204	49	PLCG2,CD74,DENND1B,IRF5
6.822e-05	-9.59	DOCK_N	interpro domains	IPR032376	5	2	18521	49	DOCK1,DOCK2
6.822e-05	-9.59	DOCK_N_sub1	interpro domains	IPR042455	5	2	18521	49	DOCK2,DOCK1
6.880e-05	-9.58	SH2DOMAIN	prints domains	PR00401	72	4	5227	17	PTPN6,VAV3,PLCG2,HCK
7.281e-05	-9.53	positive regulation of B cell activation	biological process	GO:0050871	83	4	18204	49	VAV3,SPI1,CD74,STAT6
7.389e-05	-9.51	DOCK_N	pfam domains	PF16172	5	2	17795	49	DOCK1,DOCK2
7.494e-05	-9.50	NME2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	4831	174	5	19454	49	DOCK8,GIT2,PREX1,PLCG2,AKAP13
7.541e-05	-9.49	ZF_DAG_PE_2	prosite domains	PS50081	63	4	12186	44	GMIP,PRKCD,AKAP13,VAV3
7.577e-05	-9.49	regulation of multicellular organismal process	biological process	GO:0051239	3113	20	18204	49	DENND1B,STAT6,GAB1,CSF1R,PLCG2,APOE,IRF5,ADCY7,CD74,IL6R,HIF1A,PRKCD,DOCK1,SPI1,P2RY2,VAV3,RGS14,PTPN6,DOCK8,TBXAS1
7.763e-05	-9.46	regulation of immune effector process	biological process	GO:0002697	390	7	18204	49	PTPN6,PLCG2,IRF5,DENND1B,CD74,STAT6,SPI1
8.505e-05	-9.37	ELMO1 (engulfment and cell motility 1)	protein interactions	9844	34	3	19454	49	HCK,DOCK2,DOCK1
8.526e-05	-9.37	RHOGAP	prosite domains	PS50238	65	4	12186	44	ARHGAP15,GMIP,ARHGAP27,ARHGAP33
8.604e-05	-9.36	Fc-gamma receptor signaling pathway	biological process	GO:0038094	32	3	18204	49	HCK,PRKCD,VAV3
8.699e-05	-9.35	small GTPase binding	molecular function	GO:0031267	283	6	18094	47	AKAP13,DENND1B,DOCK1,DOCK2,DOCK10,GIT2
8.699e-05	-9.35	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	24	16828	45	PIK3R5,MYO1F,PREX1,DOCK10,P2RY6,PARVG,WDFY4,TBC1D8,RHBDF2,DOCK2,ADCY7,DOCK8,STAT6,TLN1,EHBP1L1,SBNO2,ARHGAP15,DOCK1,BLNK,IRF5,GMIP,ELMO1,IPCEF1,AKAP13
8.699e-05	-9.35	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	24	16828	45	STAT6,TLN1,DOCK8,DOCK1,SBNO2,EHBP1L1,IRF5,AKAP13,DOCK10,MYO1F,P2RY6,WDFY4,TBC1D8,RHBDF2,ARHGAP15,BLNK,GMIP,ELMO1,IPCEF1,PREX1,PIK3R5,PARVG,DOCK2,ADCY7
8.750e-05	-9.34	cellular response to virus	biological process	GO:0098586	87	4	18204	49	WDFY4,GSDME,IRF5,HIF1A
8.770e-05	-9.34	IL-6 signaling pathway	WikiPathways	WP364	43	4	5310	30	PRKCD,GAB1,IL6R,HCK
9.346e-05	-9.28	Rho_GTPase_activation_prot	interpro domains	IPR008936	90	4	18521	49	ARHGAP33,ARHGAP15,GMIP,ARHGAP27
1.022e-04	-9.19	DOCK_C/D_N	interpro domains	IPR021816	6	2	18521	49	DOCK8,DOCK10
1.026e-04	-9.18	Dedicator of cytokinesis N-terminal subdomain	gene3d domains	1.20.1270.350	5	2	14470	47	DOCK1,DOCK2
1.034e-04	-9.18	response to interleukin-6	biological process	GO:0070741	34	3	18204	49	SBNO2,SPI1,IL6R
1.034e-04	-9.18	regulation of type 2 immune response	biological process	GO:0002828	34	3	18204	49	STAT6,DENND1B,CD74
1.036e-04	-9.17	CBLB (Cbl proto-oncogene B)	protein interactions	868	97	4	19454	49	VAV3,PLCG2,FYB1,BLNK
1.063e-04	-9.15	regulation of cellular process	biological process	GO:0050794	11468	43	18204	49	SBNO2,TBC1D8,DENND1B,HCK,GAB1,CARMIL3,TLN1,PLCG2,NRK,GIT2,RHBDF2,APOE,PRKCD,P2RY6,P2RY2,DOCK1,IL6R,VAV3,PREX1,RGS14,AKAP13,PTPN6,DOCK2,ARHGAP27,STAT6,ELMO1,ARHGAP33,GSDME,CSF1R,GMIP,IRF5,ADCY7,FYB1,SPI1,SKAP1,CD74,HIF1A,NEK6,ARHGAP15,BLNK,DOCK10,DOCK8,PIK3R5
1.106e-04	-9.11	DOCK_C-D_N	pfam domains	PF11878	6	2	17795	49	DOCK10,DOCK8
1.142e-04	-9.08	vesicle-mediated transport	biological process	GO:0016192	1283	12	18204	49	MYO1F,DOCK2,GIT2,APOE,ARHGAP27,PRKCD,P2RY6,DOCK1,DENND1B,HCK,VAV3,ELMO1
1.184e-04	-9.04	RhoGAP	smart domains	SM00324	64	4	9717	39	ARHGAP15,ARHGAP33,ARHGAP27,GMIP
1.229e-04	-9.00	cell-cell fusion	biological process	GO:0140253	36	3	18204	49	SBNO2,DOCK1,DOCK2
1.229e-04	-9.00	syncytium formation by plasma membrane fusion	biological process	GO:0000768	36	3	18204	49	DOCK2,SBNO2,DOCK1
1.242e-04	-8.99	The role of Nef in HIV-1 replication and disease pathogenesis	REACTOME pathways	R-HSA-164952	29	3	10285	35	ELMO1,HCK,DOCK2
1.258e-04	-8.98	C1	smart domains	SM00109	65	4	9717	39	AKAP13,VAV3,GMIP,PRKCD
1.335e-04	-8.92	negative regulation of lymphocyte apoptotic process	biological process	GO:0070229	37	3	18204	49	HIF1A,CD74,DOCK8
1.340e-04	-8.92	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	6	18204	49	PTPN6,RGS14,APOE,CD74,P2RY6,CSF1R
1.343e-04	-8.92	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	7	19454	49	PLCG2,SKAP1,PRKCD,HCK,IL6R,PTPN6,GAB1
1.384e-04	-8.89	regulation of inflammatory response	biological process	GO:0050727	428	7	18204	49	HCK,PRKCD,SBNO2,PLCG2,PTPN6,APOE,RHBDF2
1.392e-04	-8.88	Platelet activation	KEGG pathways	hsa04611	123	5	7161	30	TBXAS1,ADCY7,PIK3R5,PLCG2,TLN1
1.468e-04	-8.83	Cytokine Signaling in Immune system	REACTOME pathways	R-HSA-1280215	756	10	10285	35	CSF1R,IRF5,HIF1A,IL6R,STAT6,PRKCD,BLNK,PTPN6,TLN1,HCK
1.474e-04	-8.82	regulation of response to external stimulus	biological process	GO:0032101	1116	11	18204	49	HCK,SBNO2,CSF1R,PLCG2,APOE,RHBDF2,IL6R,CD74,SPI1,PRKCD,PTPN6
1.478e-04	-8.82	vascular endothelial growth factor production	biological process	GO:0010573	7	2	18204	49	HIF1A,IL6R
1.483e-04	-8.82	regulation of biological process	biological process	GO:0050789	12079	44	18204	49	NEK6,SPI1,DOCK8,DOCK10,ARHGAP15,ARHGAP33,FYB1,ADCY7,IRF5,GMIP,VAV3,TBXAS1,PTPN6,AKAP13,RGS14,CARMIL3,GAB1,GIT2,PLCG2,HIF1A,CD74,SKAP1,PIK3R5,BLNK,CSF1R,GSDME,ELMO1,STAT6,PREX1,IL6R,DOCK1,P2RY2,PRKCD,P2RY6,ARHGAP27,DOCK2,HCK,DENND1B,TBC1D8,SBNO2,APOE,RHBDF2,NRK,TLN1
1.506e-04	-8.80	regulation of production of molecular mediator of immune response	biological process	GO:0002700	189	5	18204	49	IRF5,PLCG2,STAT6,DENND1B,CD74
1.506e-04	-8.80	B cell activation	biological process	GO:0042113	189	5	18204	49	BLNK,DOCK10,PRKCD,PLCG2,STAT6
1.561e-04	-8.76	platelet activation	biological process	GO:0030168	101	4	18204	49	VAV3,PTPN6,TLN1,PLCG2
1.563e-04	-8.76	GTPase binding	molecular function	GO:0051020	315	6	18094	47	DOCK1,DOCK2,DOCK10,GIT2,AKAP13,DENND1B
1.565e-04	-8.76	syncytium formation	biological process	GO:0006949	39	3	18204	49	DOCK2,DOCK1,SBNO2
1.570e-04	-8.76	biological process involved in interspecies interaction between organisms	biological process	GO:0044419	1540	13	18204	49	PTPN6,PRKCD,HIF1A,CD74,IL6R,IRF5,WDFY4,APOE,PLCG2,CSF1R,GSDME,SBNO2,HCK
1.609e-04	-8.73	PRAM1 (PML-RARA regulated adaptor molecule 1)	protein interactions	84106	42	3	19454	49	NEK6,SKAP1,APOE
1.622e-04	-8.73	alpha-beta T cell activation	biological process	GO:0046631	102	4	18204	49	STAT6,IL6R,DOCK2,WDFY4
1.633e-04	-8.72	response to oxygen-containing compound	biological process	GO:1901700	1546	13	18204	49	TBXAS1,HIF1A,PRKCD,P2RY6,P2RY2,PLCG2,APOE,IRF5,ADCY7,STAT6,HCK,SBNO2,GAB1
1.748e-04	-8.65	regulation of chemokine production	biological process	GO:0032642	104	4	18204	49	CSF1R,HIF1A,IL6R,CD74
1.756e-04	-8.65	SH2 domain binding	molecular function	GO:0042169	42	3	18094	47	PTPN6,SKAP1,BLNK
1.828e-04	-8.61	negative regulation of immune response	biological process	GO:0050777	197	5	18204	49	STAT6,HCK,PTPN6,SPI1,RHBDF2
1.831e-04	-8.61	phosphorylation-dependent protein binding	molecular function	GO:0140031	8	2	18094	47	PTPN6,PLCG2
1.875e-04	-8.58	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	33	16828	45	DOCK2,ADCY7,PIK3R5,PREX1,ARHGAP27,PARVG,BLNK,ELMO1,GMIP,IPCEF1,SKAP1,ARHGAP15,ARHGAP33,GAB1,WDFY4,CSF1R,GIT2,TBC1D8,DENND1B,DOCK10,MYO1F,PRKCD,APOE,HIF1A,NEK6,VAV3,AKAP13,DOCK8,STAT6,HCK,TLN1,SBNO2,DOCK1
1.894e-04	-8.57	B cell receptor signaling pathway	KEGG pathways	ko04662	70	4	7161	30	PTPN6,PLCG2,VAV3,BLNK
1.894e-04	-8.57	B cell receptor signaling pathway	KEGG pathways	hsa04662	70	4	7161	30	PTPN6,PLCG2,VAV3,BLNK
1.910e-04	-8.56	B Cell Receptor Signaling Pathway	WikiPathways	WP23	98	5	5310	30	GAB1,PRKCD,PTPN6,PLCG2,BLNK
1.950e-04	-8.54	Rap1 signaling pathway	KEGG pathways	ko04015	210	6	7161	30	TLN1,CSF1R,SKAP1,FYB1,RGS14,ADCY7
1.950e-04	-8.54	Rap1 signaling pathway	KEGG pathways	hsa04015	210	6	7161	30	ADCY7,RGS14,FYB1,SKAP1,TLN1,CSF1R
1.961e-04	-8.54	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	45	16828	45	PRKCD,APOE,DOCK10,TBC1D8,RHBDF2,WDFY4,CSF1R,GIT2,EHBP1L1,SBNO2,DOCK1,STAT6,HCK,AKAP13,IRF5,NEK6,HIF1A,ARHGAP27,PARVG,CD74,PIK3R5,DOCK2,ADCY7,TBXAS1,ARHGAP15,P2RY2,GMIP,PLCG2,P2RY6,IL6R,DENND1B,MYO1F,DOCK8,TLN1,SPI1,VAV3,PTPN6,PREX1,SKAP1,ARHGAP33,GAB1,ELMO1,IPCEF1,BLNK,RGS14
1.961e-04	-8.54	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	45	16828	45	PREX1,PTPN6,SKAP1,GAB1,ARHGAP33,RGS14,BLNK,IPCEF1,ELMO1,IL6R,MYO1F,DENND1B,PLCG2,P2RY6,DOCK8,TLN1,VAV3,SPI1,PIK3R5,ARHGAP27,PARVG,CD74,TBXAS1,ADCY7,DOCK2,P2RY2,ARHGAP15,GMIP,DOCK10,APOE,PRKCD,WDFY4,GIT2,CSF1R,RHBDF2,TBC1D8,HCK,STAT6,EHBP1L1,SBNO2,DOCK1,IRF5,NEK6,HIF1A,AKAP13
1.978e-04	-8.53	SKAP2 (src kinase associated phosphoprotein 2)	protein interactions	8935	45	3	19454	49	HCK,FYB1,SKAP1
1.978e-04	-8.53	EPOR (erythropoietin receptor)	protein interactions	2057	45	3	19454	49	PTPN6,GAB1,PLCG2
1.978e-04	-8.53	SH3BP2 (SH3 domain binding protein 2)	protein interactions	6452	45	3	19454	49	VAV3,PLCG2,MYO1F
1.979e-04	-8.53	regulation of phosphate metabolic process	biological process	GO:0019220	1154	11	18204	49	APOE,PLCG2,CSF1R,PIK3R5,PTPN6,RGS14,CD74,IL6R,HIF1A,P2RY6,PRKCD
1.994e-04	-8.52	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	11	18204	49	P2RY6,PRKCD,CD74,IL6R,HIF1A,CSF1R,PTPN6,RGS14,PLCG2,APOE,PIK3R5
2.007e-04	-8.51	negative regulation of inflammatory response	biological process	GO:0050728	201	5	18204	49	HCK,PTPN6,PRKCD,APOE,RHBDF2
2.022e-04	-8.51	response to other organism	biological process	GO:0051707	1363	12	18204	49	IRF5,WDFY4,PLCG2,CSF1R,GSDME,SBNO2,HCK,PTPN6,PRKCD,IL6R,CD74,HIF1A
2.050e-04	-8.49	SH3_1	pfam domains	PF00018	106	4	17795	49	HCK,DOCK1,PLCG2,MYO1F
2.064e-04	-8.49	response to external biotic stimulus	biological process	GO:0043207	1366	12	18204	49	GSDME,CSF1R,HCK,SBNO2,WDFY4,IRF5,PLCG2,HIF1A,IL6R,CD74,PRKCD,PTPN6
2.091e-04	-8.47	signaling adaptor activity	molecular function	GO:0035591	113	4	18094	47	AKAP13,GAB1,BLNK,RGS14
2.255e-04	-8.40	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	21	16828	45	CSF1R,GIT2,PRKCD,PLCG2,PTPN6,IL6R,PIK3R5,PREX1,AKAP13,SPI1,RGS14,HIF1A,IRF5,NEK6,VAV3,ARHGAP15,DOCK1,ARHGAP33,GAB1,STAT6,HCK
2.344e-04	-8.36	PDGFRB (platelet derived growth factor receptor beta)	protein interactions	5159	222	5	19454	49	HIF1A,CSF1R,GAB1,PTPN6,VAV3
2.380e-04	-8.34	positive regulation of lymphocyte activation	biological process	GO:0051251	328	6	18204	49	STAT6,CD74,SPI1,PTPN6,DOCK8,VAV3
2.405e-04	-8.33	regulation of adaptive immune response	biological process	GO:0002819	209	5	18204	49	STAT6,DENND1B,PTPN6,SKAP1,ADCY7
2.444e-04	-8.32	protein domain specific binding	molecular function	GO:0019904	651	8	18094	47	BLNK,DOCK1,TLN1,ARHGAP27,PTPN6,SKAP1,HIF1A,ELMO1
2.458e-04	-8.31	phosphotyrosine residue binding	molecular function	GO:0001784	47	3	18094	47	HCK,PTPN6,PLCG2
2.532e-04	-8.28	regulation of cell activation	biological process	GO:0050865	630	8	18204	49	STAT6,CD74,SPI1,PTPN6,PRKCD,DOCK8,APOE,VAV3
2.641e-04	-8.24	PH_12	pfam domains	PF16457	9	2	17795	49	PLCG2,ELMO1
2.708e-04	-8.21	DOK1 (docking protein 1)	protein interactions	1796	50	3	19454	49	HCK,PTPN6,TLN1
2.734e-04	-8.20	negative regulation of MAP kinase activity	biological process	GO:0043407	47	3	18204	49	APOE,RGS14,PRKCD
2.800e-04	-8.18	cell chemotaxis	biological process	GO:0060326	216	5	18204	49	PREX1,VAV3,GAB1,PRKCD,IL6R
2.872e-04	-8.16	IL4R (interleukin 4 receptor)	protein interactions	3566	51	3	19454	49	STAT6,RHBDF2,PTPN6
2.978e-04	-8.12	regulation of actin cytoskeleton organization	biological process	GO:0032956	342	6	18204	49	AKAP13,CSF1R,CARMIL3,PREX1,HCK,PRKCD
3.013e-04	-8.11	BTK (Bruton tyrosine kinase)	protein interactions	695	128	4	19454	49	GAB1,BLNK,HCK,PLCG2
3.013e-04	-8.11	positive regulation of cell adhesion	biological process	GO:0045785	486	7	18204	49	CD74,SKAP1,PTPN6,DOCK1,DOCK8,VAV3,PREX1
3.025e-04	-8.10	Signaling by Interleukins	REACTOME pathways	R-HSA-449147	525	8	10285	35	HIF1A,IL6R,STAT6,CSF1R,BLNK,PTPN6,HCK,TLN1
3.026e-04	-8.10	regulation of cytokine production involved in immune response	biological process	GO:0002718	120	4	18204	49	IRF5,DENND1B,CD74,PLCG2
3.034e-04	-8.10	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME pathways	R-HSA-983695	39	3	10285	35	PLCG2,BLNK,PTPN6
3.121e-04	-8.07	chemotaxis	biological process	GO:0006935	345	6	18204	49	GAB1,VAV3,DOCK2,PREX1,IL6R,PRKCD
3.177e-04	-8.05	defense response	biological process	GO:0006952	1431	12	18204	49	PLCG2,IRF5,HCK,STAT6,CSF1R,PTPN6,BLNK,PRKCD,SPI1,CD74,IL6R,HIF1A
3.200e-04	-8.05	lipid binding	molecular function	GO:0008289	861	9	18094	47	TLN1,APOE,DENND1B,BLNK,PREX1,HCK,ARHGAP33,GSDME,FYB1
3.219e-04	-8.04	taxis	biological process	GO:0042330	347	6	18204	49	GAB1,VAV3,PREX1,DOCK2,IL6R,PRKCD
3.220e-04	-8.04	ELMO2 (engulfment and cell motility 2)	protein interactions	63916	53	3	19454	49	DOCK2,DOCK1,ELMO1
3.346e-04	-8.00	Platelet activation, signaling and aggregation	REACTOME pathways	R-HSA-76002	282	6	10285	35	PRKCD,PLCG2,VAV3,PIK3R5,PTPN6,TLN1
3.369e-04	-8.00	LAT2 (linker for activation of T cells family member 2)	protein interactions	7462	11	2	19454	49	PLCG2,GAB1
3.430e-04	-7.98	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	21	16828	45	DENND1B,DOCK10,PTPN6,PRKCD,PLCG2,GIT2,CSF1R,WDFY4,DOCK2,TBC1D8,ARHGAP33,DOCK1,GAB1,SKAP1,SBNO2,ARHGAP15,BLNK,AKAP13,ELMO1,GMIP,IPCEF1
3.430e-04	-7.98	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	21	16828	45	BLNK,AKAP13,ELMO1,GMIP,IPCEF1,DOCK1,ARHGAP33,GAB1,SKAP1,SBNO2,ARHGAP15,GIT2,CSF1R,WDFY4,DOCK2,TBC1D8,DENND1B,DOCK10,PTPN6,PRKCD,PLCG2
3.491e-04	-7.96	regulation of anatomical structure size	biological process	GO:0090066	498	7	18204	49	P2RY2,PRKCD,HCK,PREX1,TBXAS1,VAV3,APOE
3.577e-04	-7.94	positive regulation of cytokine production	biological process	GO:0001819	500	7	18204	49	PLCG2,IRF5,HIF1A,CD74,IL6R,DENND1B,CSF1R
3.658e-04	-7.91	lymph_node	COSMIC cancer mutations	lymph_node	1703	13	16828	45	BLNK,HIF1A,ELMO1,SPI1,AKAP13,HCK,STAT6,DOCK1,CSF1R,DOCK2,DOCK10,PLCG2,CD74
3.993e-04	-7.83	ITK (IL2 inducible T cell kinase)	protein interactions	3702	57	3	19454	49	GAB1,BLNK,PLCG2
3.997e-04	-7.82	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	10	18204	49	PRKCD,SBNO2,P2RY6,P2RY2,HCK,STAT6,HIF1A,GAB1,PLCG2,ADCY7
4.032e-04	-7.82	positive regulation of leukocyte activation	biological process	GO:0002696	362	6	18204	49	DOCK8,PTPN6,VAV3,STAT6,CD74,SPI1
4.036e-04	-7.81	RWDD1 (RWD domain containing 1)	protein interactions	51389	12	2	19454	49	CD74,P2RY6
4.102e-04	-7.80	lymphocyte proliferation	biological process	GO:0046651	130	4	18204	49	DOCK8,DOCK2,PTPN6,PRKCD
4.185e-04	-7.78	anchoring junction	cellular component	GO:0070161	902	9	19108	49	HCK,FYB1,SKAP1,PARVG,PRKCD,GIT2,GAB1,PTPN6,TLN1
4.198e-04	-7.78	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	5	19454	49	BLNK,FYB1,GAB1,GIT2,DOCK1
4.212e-04	-7.77	response to oxidative stress	biological process	GO:0006979	365	6	18204	49	APOE,IPCEF1,STAT6,HIF1A,PRKCD,RGS14
4.248e-04	-7.76	pleura-mesothelioma	COSMIC cancer mutations	pleura-mesothelioma	4189	22	16828	45	VAV3,NEK6,HIF1A,IRF5,SPI1,AKAP13,TLN1,HCK,STAT6,DOCK1,CSF1R,GIT2,IL6R,PLCG2,PRKCD,RGS14,ARHGAP15,GAB1,ARHGAP33,PIK3R5,PREX1,PTPN6
4.312e-04	-7.75	regulation of cytokine production	biological process	GO:0001817	863	9	18204	49	PTPN6,PLCG2,IRF5,ADCY7,DENND1B,CD74,IL6R,HIF1A,CSF1R
4.336e-04	-7.74	locomotion	biological process	GO:0040011	367	6	18204	49	IL6R,PRKCD,GAB1,DOCK2,PREX1,VAV3
4.451e-04	-7.72	PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)	protein interactions	5295	394	6	19454	49	GAB1,CSF1R,PTPN6,HCK,PLCG2,VAV3
4.595e-04	-7.69	negative regulation of leukocyte apoptotic process	biological process	GO:2000107	56	3	18204	49	HIF1A,CD74,DOCK8
4.595e-04	-7.69	B cell activation involved in immune response	biological process	GO:0002312	56	3	18204	49	PLCG2,STAT6,DOCK10
4.601e-04	-7.68	mononuclear cell proliferation	biological process	GO:0032943	134	4	18204	49	PTPN6,PRKCD,DOCK8,DOCK2
4.605e-04	-7.68	positive thymic T cell selection	biological process	GO:0045059	12	2	18204	49	CD74,DOCK2
4.605e-04	-7.68	negative thymic T cell selection	biological process	GO:0045060	12	2	18204	49	DOCK2,CD74
4.790e-04	-7.64	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	23	16828	45	PTPN6,PRKCD,PLCG2,PREX1,IL6R,PIK3R5,DOCK2,CSF1R,GIT2,ARHGAP33,DOCK1,GAB1,ARHGAP15,STAT6,HCK,TLN1,SPI1,AKAP13,NEK6,HIF1A,IRF5,VAV3,RGS14
4.790e-04	-7.64	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	23	16828	45	ARHGAP15,GAB1,ARHGAP33,RGS14,PTPN6,PIK3R5,PREX1,DOCK2,DOCK1,TLN1,HCK,STAT6,SPI1,AKAP13,VAV3,IRF5,HIF1A,NEK6,PLCG2,PRKCD,IL6R,CSF1R,GIT2
4.841e-04	-7.63	PTPN6 (protein tyrosine phosphatase non-receptor type 6)	protein interactions	5777	260	5	19454	49	PLCG2,PRKCD,STAT6,PTPN6,BLNK
4.842e-04	-7.63	regulation of lymphocyte apoptotic process	biological process	GO:0070228	57	3	18204	49	HIF1A,CD74,DOCK8
4.845e-04	-7.63	biological regulation	biological process	GO:0065007	12501	44	18204	49	PREX1,DOCK1,P2RY2,PRKCD,P2RY6,IL6R,DOCK2,ARHGAP27,TBC1D8,SBNO2,HCK,DENND1B,RHBDF2,APOE,TLN1,NRK,SKAP1,HIF1A,CD74,BLNK,PIK3R5,ELMO1,CSF1R,GSDME,STAT6,VAV3,TBXAS1,PTPN6,RGS14,AKAP13,CARMIL3,GAB1,GIT2,PLCG2,NEK6,SPI1,DOCK10,DOCK8,ARHGAP15,ARHGAP33,ADCY7,IRF5,FYB1,GMIP
4.866e-04	-7.63	regulation of MAP kinase activity	biological process	GO:0043405	136	4	18204	49	PIK3R5,APOE,RGS14,PRKCD
4.887e-04	-7.62	Signaling by Rho GTPases	REACTOME pathways	R-HSA-194315	426	7	10285	35	ARHGAP15,ARHGAP33,GMIP,ARHGAP27,AKAP13,PREX1,VAV3
4.987e-04	-7.60	leukocyte migration	biological process	GO:0050900	245	5	18204	49	HCK,IL6R,DOCK8,PREX1,VAV3
5.058e-04	-7.59	G protein-coupled purinergic nucleotide receptor activity	molecular function	GO:0045028	13	2	18094	47	P2RY6,P2RY2
5.067e-04	-7.59	protein phosphorylated amino acid binding	molecular function	GO:0045309	60	3	18094	47	HCK,PLCG2,PTPN6
5.096e-04	-7.58	mammary gland epithelium development	biological process	GO:0061180	58	3	18204	49	HIF1A,STAT6,CSF1R
5.129e-04	-7.58	regulation of kinase activity	biological process	GO:0043549	531	7	18204	49	APOE,PIK3R5,RGS14,CSF1R,IL6R,CD74,PRKCD
5.175e-04	-7.57	regulation of leukocyte mediated immunity	biological process	GO:0002703	247	5	18204	49	DENND1B,STAT6,SPI1,PTPN6,PLCG2
5.176e-04	-7.57	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	30	16828	45	RGS14,ELMO1,GMIP,P2RY2,GAB1,ARHGAP33,TBXAS1,DOCK2,PREX1,PTPN6,PARVG,VAV3,NEK6,IRF5,AKAP13,TLN1,HCK,DOCK1,SBNO2,EHBP1L1,CSF1R,GIT2,WDFY4,RHBDF2,TBC1D8,DOCK10,MYO1F,DENND1B,PLCG2,PRKCD
5.284e-04	-7.55	positive regulation of transferase activity	biological process	GO:0051347	381	6	18204	49	APOE,PIK3R5,PRKCD,IL6R,CD74,CSF1R
5.284e-04	-7.55	positive regulation of cell activation	biological process	GO:0050867	381	6	18204	49	PTPN6,DOCK8,SPI1,STAT6,CD74,VAV3
5.367e-04	-7.53	lung-carcinoma	COSMIC cancer mutations	lung-carcinoma	4255	22	16828	45	IL6R,PIK3R5,PREX1,PRKCD,PLCG2,PTPN6,CSF1R,GIT2,STAT6,HCK,TLN1,ARHGAP15,ARHGAP33,DOCK1,GAB1,RGS14,IRF5,NEK6,HIF1A,VAV3,SPI1,AKAP13
5.432e-04	-7.52	negative T cell selection	biological process	GO:0043383	13	2	18204	49	CD74,DOCK2
5.432e-04	-7.52	G protein-coupled purinergic nucleotide receptor signaling pathway	biological process	GO:0035589	13	2	18204	49	P2RY6,P2RY2
5.507e-04	-7.50	regulation of actin filament-based process	biological process	GO:0032970	384	6	18204	49	AKAP13,PRKCD,HCK,PREX1,CSF1R,CARMIL3
5.547e-04	-7.50	LYSMD2 (LysM domain containing 2)	protein interactions	256586	14	2	19454	49	PRKCD,HIF1A
5.547e-04	-7.50	MS4A2 (membrane spanning 4-domains A2)	protein interactions	2206	14	2	19454	49	PRKCD,PTPN6
5.623e-04	-7.48	C1-like_sf	interpro domains	IPR046349	61	3	18521	49	PRKCD,AKAP13,GMIP
5.778e-04	-7.46	FYN (FYN proto-oncogene, Src family tyrosine kinase)	protein interactions	2534	414	6	19454	49	FYB1,CSF1R,ARHGAP33,PRKCD,PLCG2,SKAP1
5.815e-04	-7.45	regulation of supramolecular fiber organization	biological process	GO:1902903	388	6	18204	49	CARMIL3,APOE,PREX1,HCK,AKAP13,PRKCD
6.032e-04	-7.41	ERBB2 (erb-b2 receptor tyrosine kinase 2)	protein interactions	2064	583	7	19454	49	GAB1,BLNK,HCK,PTPN6,TLN1,PLCG2,VAV3
6.144e-04	-7.39	transport	biological process	GO:0006810	3615	20	18204	49	VAV3,HIF1A,CD74,DOCK1,PRKCD,P2RY6,ARHGAP27,DOCK2,IPCEF1,MYO1F,RGS14,GSDME,ELMO1,ARHGAP33,HCK,DENND1B,APOE,GIT2,RHBDF2,PLCG2
6.159e-04	-7.39	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	8	19454	49	SKAP1,DOCK1,VAV3,CSF1R,PTPN6,GAB1,BLNK,IRF5
6.327e-04	-7.37	immunological synapse formation	biological process	GO:0001771	14	2	18204	49	DOCK2,DOCK8
6.327e-04	-7.37	T-helper cell lineage commitment	biological process	GO:0002295	14	2	18204	49	IL6R,STAT6
6.327e-04	-7.37	interleukin-6-mediated signaling pathway	biological process	GO:0070102	14	2	18204	49	IL6R,SPI1
6.361e-04	-7.36	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	13	16828	45	RGS14,BLNK,WDFY4,CSF1R,IPCEF1,ELMO1,ADCY7,DOCK2,DOCK8,SKAP1,SBNO2,PTPN6,DOCK1
6.361e-04	-7.36	functioning	COSMIC cancer mutations	functioning	1803	13	16828	45	ELMO1,IPCEF1,DOCK2,ADCY7,WDFY4,BLNK,RGS14,CSF1R,SBNO2,SKAP1,DOCK1,PTPN6,DOCK8
6.617e-04	-7.32	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	4	7161	30	ADCY7,P2RY2,PLCG2,PRKCD
6.617e-04	-7.32	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	4	7161	30	PLCG2,PRKCD,ADCY7,P2RY2
6.691e-04	-7.31	regulation of protein phosphorylation	biological process	GO:0001932	917	9	18204	49	CSF1R,IL6R,CD74,PRKCD,APOE,PIK3R5,PTPN6,PLCG2,RGS14
6.711e-04	-7.31	TRAF6 (TNF receptor associated factor 6)	protein interactions	7189	426	6	19454	49	STAT6,PRKCD,VAV3,HIF1A,PTPN6,IRF5
6.860e-04	-7.28	positive regulation of leukocyte migration	biological process	GO:0002687	149	4	18204	49	DOCK8,CSF1R,CD74,IL6R
7.136e-04	-7.25	multicellular organismal process	biological process	GO:0032501	6177	28	18204	49	SBNO2,TBC1D8,GAB1,TLN1,PLCG2,APOE,GIT2,IL6R,PRKCD,P2RY2,VAV3,PREX1,PTPN6,RGS14,AKAP13,TBXAS1,DOCK2,STAT6,CSF1R,GSDME,WDFY4,ADCY7,CD74,HIF1A,SPI1,DOCK8,BLNK,DOCK10
7.212e-04	-7.23	positive regulation of leukocyte mediated immunity	biological process	GO:0002705	151	4	18204	49	SPI1,PLCG2,DENND1B,STAT6
7.242e-04	-7.23	Innate Immune System	REACTOME pathways	R-HSA-168249	1285	12	10285	35	STAT6,ADCY7,GAB1,PLCG2,VAV3,HCK,TLN1,DOCK1,PRKCD,DOCK2,PTPN6,ELMO1
7.268e-04	-7.23	P2Y receptors	REACTOME pathways	R-HSA-417957	12	2	10285	35	P2RY2,P2RY6
7.286e-04	-7.22	angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	angioimmunoblastic_T_cell_lymphoma	269	5	16828	45	PLCG2,STAT6,CSF1R,HCK,BLNK
7.288e-04	-7.22	regulation of phospholipid transport	biological process	GO:2001138	15	2	18204	49	APOE,PRKCD
7.444e-04	-7.20	myeloid cell activation involved in immune response	biological process	GO:0002275	66	3	18204	49	SBNO2,PLCG2,DOCK2
7.444e-04	-7.20	peptidyl-tyrosine phosphorylation	biological process	GO:0018108	66	3	18204	49	CSF1R,PTPN6,HCK
7.484e-04	-7.20	regulation of leukocyte proliferation	biological process	GO:0070663	268	5	18204	49	VAV3,CSF1R,PTPN6,STAT6,CD74
7.555e-04	-7.19	T cell receptor complex	cellular component	GO:0042101	16	2	19108	49	SKAP1,PTPN6
7.848e-04	-7.15	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	38	16828	45	DOCK8,STAT6,TLN1,HCK,SBNO2,DOCK1,IRF5,VAV3,AKAP13,DENND1B,MYO1F,DOCK10,PRKCD,PLCG2,APOE,P2RY6,GIT2,CSF1R,TBC1D8,RHBDF2,P2RY2,SKAP1,ARHGAP15,ARHGAP33,GAB1,BLNK,RGS14,ELMO1,GMIP,IPCEF1,PIK3R5,PREX1,ARHGAP27,PARVG,PTPN6,TBXAS1,DOCK2,ADCY7
7.848e-04	-7.15	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	38	16828	45	DOCK2,ADCY7,TBXAS1,ARHGAP27,PARVG,PTPN6,PIK3R5,PREX1,GMIP,ELMO1,IPCEF1,BLNK,RGS14,SKAP1,ARHGAP15,ARHGAP33,GAB1,P2RY2,TBC1D8,RHBDF2,CSF1R,GIT2,PRKCD,PLCG2,APOE,P2RY6,DENND1B,MYO1F,DOCK10,AKAP13,IRF5,VAV3,SBNO2,DOCK1,DOCK8,STAT6,HCK,TLN1
8.122e-04	-7.12	peptidyl-tyrosine modification	biological process	GO:0018212	68	3	18204	49	CSF1R,HCK,PTPN6
8.251e-04	-7.10	ARL4A (ADP ribosylation factor like GTPase 4A)	protein interactions	10124	17	2	19454	49	DOCK1,ELMO1
8.410e-04	-7.08	DH-domain	interpro domains	IPR000219	70	3	18521	49	VAV3,AKAP13,PREX1
8.571e-04	-7.06	Signal regulatory protein (SIRP) family interactions	REACTOME pathways	R-HSA-391160	13	2	10285	35	PTPN6,FYB1
8.686e-04	-7.05	regulation of protein-containing complex assembly	biological process	GO:0043254	419	6	18204	49	PREX1,HCK,PRKCD,SKAP1,APOE,PLCG2
8.765e-04	-7.04	DBL_dom_sf	interpro domains	IPR035899	71	3	18521	49	AKAP13,PREX1,VAV3
8.776e-04	-7.04	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	38	16828	45	BLNK,GMIP,ELMO1,IPCEF1,P2RY2,SKAP1,ARHGAP15,ARHGAP33,GAB1,TBXAS1,DOCK2,ADCY7,PIK3R5,PREX1,PARVG,CD74,PTPN6,HIF1A,NEK6,IRF5,VAV3,AKAP13,SPI1,DOCK8,STAT6,TLN1,EHBP1L1,DOCK1,WDFY4,CSF1R,GIT2,TBC1D8,RHBDF2,DOCK10,MYO1F,PRKCD,PLCG2,P2RY6
8.776e-04	-7.04	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	38	16828	45	PREX1,PIK3R5,CD74,PARVG,PTPN6,TBXAS1,DOCK2,ADCY7,P2RY2,ARHGAP33,GAB1,SKAP1,ARHGAP15,BLNK,ELMO1,GMIP,IPCEF1,MYO1F,DOCK10,P2RY6,PRKCD,PLCG2,GIT2,CSF1R,WDFY4,TBC1D8,RHBDF2,STAT6,TLN1,DOCK8,DOCK1,EHBP1L1,HIF1A,IRF5,NEK6,VAV3,AKAP13,SPI1
8.972e-04	-7.02	PLSCR1 (phospholipid scramblase 1)	protein interactions	5359	171	4	19454	49	P2RY6,PRKCD,DOCK2,ADCY7
9.162e-04	-7.00	positive regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050731	161	4	18204	49	CSF1R,CD74,IL6R,PLCG2
9.407e-04	-6.97	CD4-positive, alpha-beta T cell lineage commitment	biological process	GO:0043373	17	2	18204	49	IL6R,STAT6
9.434e-04	-6.97	RhoGEF	pfam domains	PF00621	70	3	17795	49	PREX1,VAV3,AKAP13
9.514e-04	-6.96	breast-carcinoma-ER-PR-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-ER-PR-positive_carcinoma	1881	13	16828	45	PLCG2,PRKCD,PTPN6,P2RY6,PIK3R5,DOCK10,CSF1R,GAB1,P2RY2,TLN1,STAT6,ELMO1,VAV3
9.514e-04	-6.96	ER-PR-positive_carcinoma	COSMIC cancer mutations	ER-PR-positive_carcinoma	1881	13	16828	45	PTPN6,P2RY6,PLCG2,PRKCD,DOCK10,PIK3R5,CSF1R,GAB1,TLN1,STAT6,P2RY2,ELMO1,VAV3
9.577e-04	-6.95	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	7	10285	35	PRKCD,GAB1,VAV3,PREX1,AKAP13,TLN1,ADCY7
9.586e-04	-6.95	lung-carcinoma-undifferentiated_carcinoma	COSMIC cancer mutations	lung-carcinoma-undifferentiated_carcinoma	1408	11	16828	45	VAV3,GAB1,P2RY2,TLN1,STAT6,CSF1R,PLCG2,PRKCD,PTPN6,P2RY6,PIK3R5
9.696e-04	-6.94	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	6	18204	49	GAB1,CSF1R,STAT6,HCK,BLNK,RGS14
9.772e-04	-6.93	regulation of transport	biological process	GO:0051049	1621	12	18204	49	CD74,HIF1A,PRKCD,P2RY6,SPI1,P2RY2,PTPN6,DOCK2,HCK,PLCG2,APOE,RHBDF2
1.016e-03	-6.89	undifferentiated_carcinoma	COSMIC cancer mutations	undifferentiated_carcinoma	1418	11	16828	45	STAT6,TLN1,PIK3R5,P2RY2,P2RY6,GAB1,PTPN6,PRKCD,PLCG2,VAV3,CSF1R
1.026e-03	-6.88	lymphocyte mediated immunity	biological process	GO:0002449	166	4	18204	49	STAT6,CD74,PTPN6,PRKCD
1.041e-03	-6.87	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	4	19454	49	HCK,PTPN6,VAV3,PLCG2
1.043e-03	-6.87	negative regulation of intracellular signal transduction	biological process	GO:1902532	599	7	18204	49	APOE,RGS14,PTPN6,PRKCD,SPI1,CD74,HIF1A
1.051e-03	-6.86	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	11	19454	49	SPI1,CD74,APOE,ADCY7,HIF1A,VAV3,PRKCD,SKAP1,PLCG2,HCK,IL6R
1.056e-03	-6.85	positive regulation of type 2 immune response	biological process	GO:0002830	18	2	18204	49	DENND1B,CD74
1.056e-03	-6.85	negative regulation of platelet activation	biological process	GO:0010544	18	2	18204	49	APOE,PRKCD
1.082e-03	-6.83	NRAGE signals death through JNK	REACTOME pathways	R-HSA-193648	60	3	10285	35	AKAP13,PREX1,VAV3
1.115e-03	-6.80	negative regulation of defense response	biological process	GO:0031348	293	5	18204	49	HCK,PTPN6,PRKCD,APOE,RHBDF2
1.121e-03	-6.79	negative regulation of MAPK cascade	biological process	GO:0043409	170	4	18204	49	PRKCD,PTPN6,RGS14,APOE
1.122e-03	-6.79	T cell proliferation	biological process	GO:0042098	76	3	18204	49	DOCK8,DOCK2,PTPN6
1.130e-03	-6.79	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	22	16828	45	PIK3R5,PREX1,PTPN6,RGS14,ARHGAP15,ARHGAP33,GAB1,GIT2,CSF1R,IL6R,PRKCD,PLCG2,IRF5,NEK6,HIF1A,VAV3,SPI1,AKAP13,STAT6,TLN1,HCK,DOCK1
1.135e-03	-6.78	Regulation of actin dynamics for phagocytic cup formation	REACTOME pathways	R-HSA-2029482	61	3	10285	35	ELMO1,DOCK1,VAV3
1.139e-03	-6.78	CDC42 (cell division cycle 42)	protein interactions	998	1280	10	19454	49	TBC1D8,DOCK8,EHBP1L1,PLCG2,NEK6,GMIP,ARHGAP27,DOCK10,PREX1,GIT2
1.143e-03	-6.77	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	6	10285	35	PRKCD,GAB1,PLCG2,VAV3,TLN1,ADCY7
1.154e-03	-6.76	HCK (HCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3055	183	4	19454	49	ELMO1,PLCG2,GAB1,HCK
1.169e-03	-6.75	positive regulation of cell population proliferation	biological process	GO:0008284	992	9	18204	49	PTPN6,CSF1R,VAV3,CD74,IL6R,HCK,HIF1A,P2RY6,TBC1D8
1.171e-03	-6.75	negative regulation of secretion	biological process	GO:0051048	172	4	18204	49	RHBDF2,APOE,SPI1,CD74
1.179e-03	-6.74	macrophage activation involved in immune response	biological process	GO:0002281	19	2	18204	49	SBNO2,PLCG2
1.179e-03	-6.74	alpha-beta T cell lineage commitment	biological process	GO:0002363	19	2	18204	49	IL6R,STAT6
1.186e-03	-6.74	regulation of phosphorylation	biological process	GO:0042325	994	9	18204	49	PRKCD,IL6R,CD74,CSF1R,RGS14,PLCG2,PTPN6,APOE,PIK3R5
1.218e-03	-6.71	nucleotide receptor activity	molecular function	GO:0016502	20	2	18094	47	P2RY6,P2RY2
1.218e-03	-6.71	purinergic nucleotide receptor activity	molecular function	GO:0001614	20	2	18094	47	P2RY2,P2RY6
1.239e-03	-6.69	regulation of epithelial cell migration	biological process	GO:0010632	300	5	18204	49	GAB1,APOE,PLCG2,DOCK1,HIF1A
1.245e-03	-6.69	positive regulation of gene expression	biological process	GO:0010628	1212	10	18204	49	IRF5,BLNK,PLCG2,CSF1R,HIF1A,STAT6,IL6R,DENND1B,CD74,SPI1
1.248e-03	-6.69	regulation of interleukin-6 production	biological process	GO:0032675	175	4	18204	49	CD74,IL6R,PTPN6,PLCG2
1.252e-03	-6.68	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	14	16828	45	AKAP13,ELMO1,VAV3,BLNK,DOCK1,GAB1,SBNO2,SKAP1,ARHGAP15,STAT6,TLN1,DOCK2,WDFY4,DOCK10
1.252e-03	-6.68	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	14	16828	45	GAB1,DOCK1,ARHGAP15,SKAP1,SBNO2,TLN1,STAT6,AKAP13,ELMO1,VAV3,BLNK,DOCK10,DOCK2,WDFY4
1.274e-03	-6.67	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002460	176	4	18204	49	PRKCD,STAT6,IL6R,CD74
1.274e-03	-6.67	blood coagulation	biological process	GO:0007596	176	4	18204	49	VAV3,PLCG2,TLN1,PTPN6
1.276e-03	-6.66	positive regulation of kinase activity	biological process	GO:0033674	302	5	18204	49	CD74,IL6R,PRKCD,PIK3R5,CSF1R
1.284e-03	-6.66	CH_dom	interpro domains	IPR001715	81	3	18521	49	PARVG,EHBP1L1,VAV3
1.310e-03	-6.64	Nucleotide-like (purinergic) receptors	REACTOME pathways	R-HSA-418038	16	2	10285	35	P2RY2,P2RY6
1.327e-03	-6.62	WAS (WASP actin nucleation promoting factor)	protein interactions	7454	86	3	19454	49	FYB1,HCK,RGS14
1.329e-03	-6.62	coagulation	biological process	GO:0050817	178	4	18204	49	PTPN6,TLN1,PLCG2,VAV3
1.331e-03	-6.62	CH_dom_sf	interpro domains	IPR036872	82	3	18521	49	PARVG,VAV3,EHBP1L1
1.356e-03	-6.60	positive regulation of epithelial cell migration	biological process	GO:0010634	179	4	18204	49	HIF1A,PLCG2,DOCK1,GAB1
1.363e-03	-6.60	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	14	16828	45	AKAP13,ELMO1,VAV3,BLNK,GAB1,DOCK1,ARHGAP15,SKAP1,SBNO2,TLN1,STAT6,DOCK2,WDFY4,DOCK10
1.390e-03	-6.58	FCGR2B (Fc gamma receptor IIb)	protein interactions	2213	22	2	19454	49	PTPN6,GAB1
1.394e-03	-6.58	GDS_CDC24_CS	interpro domains	IPR001331	21	2	18521	49	PREX1,VAV3
1.398e-03	-6.57	T cell activation involved in immune response	biological process	GO:0002286	82	3	18204	49	IL6R,CD74,STAT6
1.412e-03	-6.56	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	24	16828	45	DOCK1,STAT6,TLN1,HCK,SPI1,AKAP13,NEK6,IRF5,HIF1A,VAV3,PRKCD,PLCG2,DOCK10,IL6R,CSF1R,GIT2,WDFY4,ARHGAP33,GAB1,ARHGAP15,RGS14,PTPN6,PREX1,PIK3R5
1.412e-03	-6.56	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	24	16828	45	PRKCD,PLCG2,DOCK10,IL6R,GIT2,CSF1R,WDFY4,DOCK1,STAT6,TLN1,HCK,AKAP13,SPI1,IRF5,NEK6,HIF1A,VAV3,PTPN6,PREX1,PIK3R5,ARHGAP33,GAB1,ARHGAP15,RGS14
1.413e-03	-6.56	response to reactive oxygen species	biological process	GO:0000302	181	4	18204	49	HIF1A,STAT6,PRKCD,APOE
1.414e-03	-6.56	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	6	10285	35	VAV3,GAB1,PLCG2,PRKCD,ADCY7,TLN1
1.442e-03	-6.54	hemostasis	biological process	GO:0007599	182	4	18204	49	VAV3,PTPN6,TLN1,PLCG2
1.443e-03	-6.54	prostanoid biosynthetic process	biological process	GO:0046457	21	2	18204	49	CD74,TBXAS1
1.443e-03	-6.54	thymic T cell selection	biological process	GO:0045061	21	2	18204	49	CD74,DOCK2
1.443e-03	-6.54	positive regulation by host of viral process	biological process	GO:0044794	21	2	18204	49	APOE,CSF1R
1.443e-03	-6.54	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	biological process	GO:0043369	21	2	18204	49	STAT6,IL6R
1.443e-03	-6.54	prostaglandin biosynthetic process	biological process	GO:0001516	21	2	18204	49	TBXAS1,CD74
1.468e-03	-6.52	regulation of cellular component organization	biological process	GO:0051128	2455	15	18204	49	NEK6,PREX1,PRKCD,SKAP1,HIF1A,DOCK2,AKAP13,ARHGAP33,CARMIL3,CSF1R,TBC1D8,HCK,APOE,TLN1,PLCG2
1.472e-03	-6.52	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	39	16828	45	WDFY4,GIT2,CSF1R,RHBDF2,TBC1D8,DOCK10,MYO1F,PLCG2,PRKCD,P2RY6,VAV3,NEK6,IRF5,HIF1A,SPI1,AKAP13,DOCK8,HCK,TLN1,STAT6,EHBP1L1,DOCK1,TBXAS1,ADCY7,DOCK2,PIK3R5,PREX1,PTPN6,CD74,PARVG,BLNK,IPCEF1,GMIP,ELMO1,P2RY2,ARHGAP15,SKAP1,GAB1,ARHGAP33
1.487e-03	-6.51	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	43	16828	45	DOCK1,SBNO2,EHBP1L1,STAT6,TLN1,HCK,DOCK8,SPI1,AKAP13,NEK6,IRF5,HIF1A,VAV3,P2RY6,PRKCD,APOE,PLCG2,DENND1B,DOCK10,MYO1F,IL6R,TBC1D8,RHBDF2,GIT2,CSF1R,WDFY4,ARHGAP33,GAB1,SKAP1,ARHGAP15,P2RY2,ELMO1,GMIP,BLNK,RGS14,CD74,PARVG,PTPN6,PREX1,PIK3R5,DOCK2,ADCY7,TBXAS1
1.489e-03	-6.51	localization	biological process	GO:0051179	4474	22	18204	49	RGS14,DOCK2,ARHGAP27,P2RY6,PRKCD,DOCK1,VAV3,PLCG2,GIT2,RHBDF2,APOE,DENND1B,HCK,MYO1F,IPCEF1,SKAP1,CD74,HIF1A,FYB1,ELMO1,ARHGAP33,GSDME
1.490e-03	-6.51	Signaling by PTK6	REACTOME pathways	R-HSA-8848021	67	3	10285	35	DOCK1,HIF1A,ELMO1
1.498e-03	-6.50	regulation of protein modification process	biological process	GO:0031399	1242	10	18204	49	CSF1R,PRKCD,IL6R,CD74,HIF1A,APOE,PIK3R5,PLCG2,PTPN6,RGS14
1.506e-03	-6.50	MTOR (mechanistic target of rapamycin kinase)	protein interactions	2475	335	5	19454	49	PRKCD,PREX1,P2RY6,CD74,HIF1A
1.514e-03	-6.49	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	4	19454	49	IL6R,HCK,GAB1,SKAP1
1.517e-03	-6.49	CBL (Cbl proto-oncogene)	protein interactions	867	499	6	19454	49	HCK,FYB1,PTPN6,CSF1R,BLNK,HIF1A
1.518e-03	-6.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	7	19454	49	GAB1,PREX1,FYB1,DOCK8,PRKCD,EHBP1L1,RHBDF2
1.531e-03	-6.48	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051897	185	4	18204	49	PIK3R5,CSF1R,VAV3,PTPN6
1.550e-03	-6.47	regulation of protein kinase activity	biological process	GO:0045859	469	6	18204	49	APOE,CSF1R,PIK3R5,PRKCD,RGS14,IL6R
1.566e-03	-6.46	ERBB3 (erb-b2 receptor tyrosine kinase 3)	protein interactions	2065	338	5	19454	49	BLNK,PTPN6,HCK,VAV3,PLCG2
1.573e-03	-6.46	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	3	14470	47	VAV3,PREX1,AKAP13
1.573e-03	-6.45	T-Cell antigen Receptor (TCR) Signaling Pathway	WikiPathways	WP69	91	4	5310	30	SKAP1,PRKCD,VAV3,FYB1
1.575e-03	-6.45	guanyl-nucleotide exchange factor complex	cellular component	GO:0032045	23	2	19108	49	DOCK1,ELMO1
1.584e-03	-6.45	positive regulation of cell adhesion mediated by integrin	biological process	GO:0033630	22	2	18204	49	PTPN6,SKAP1
1.586e-03	-6.45	phospholipid binding	molecular function	GO:0005543	489	6	18094	47	GSDME,ARHGAP33,PREX1,TLN1,DENND1B,APOE
1.595e-03	-6.44	establishment of localization	biological process	GO:0051234	3887	20	18204	49	RHBDF2,GIT2,APOE,PLCG2,ARHGAP33,ELMO1,GSDME,DENND1B,HCK,DOCK2,IPCEF1,ARHGAP27,RGS14,MYO1F,VAV3,PRKCD,P2RY6,DOCK1,CD74,HIF1A
1.598e-03	-6.44	regulation of transferase activity	biological process	GO:0051338	645	7	18204	49	RGS14,PIK3R5,APOE,PRKCD,CD74,IL6R,CSF1R
1.644e-03	-6.41	Nucleotide GPCRs	WikiPathways	WP80	11	2	5310	30	P2RY2,P2RY6
1.656e-03	-6.40	Crebbp (CREB binding protein)	protein interactions	12914	24	2	19454	49	HIF1A,SPI1
1.663e-03	-6.40	Regulation of signaling by CBL	REACTOME pathways	R-HSA-912631	18	2	10285	35	HCK,BLNK
1.669e-03	-6.40	wound healing	biological process	GO:0042060	321	5	18204	49	VAV3,HIF1A,PTPN6,TLN1,PLCG2
1.707e-03	-6.37	regulation of defense response	biological process	GO:0031347	843	8	18204	49	PTPN6,PLCG2,RHBDF2,APOE,SBNO2,PRKCD,SPI1,HCK
1.758e-03	-6.34	cell development	biological process	GO:0048468	2236	14	18204	49	PTPN6,BLNK,DOCK10,DOCK2,CD74,IL6R,HIF1A,SPI1,PREX1,PLCG2,APOE,STAT6,SBNO2,CSF1R
1.769e-03	-6.34	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	3	18204	49	CD74,PRKCD,APOE
1.769e-03	-6.34	regulation of leukocyte apoptotic process	biological process	GO:2000106	89	3	18204	49	CD74,HIF1A,DOCK8
1.810e-03	-6.31	phosphoprotein binding	molecular function	GO:0051219	93	3	18094	47	PLCG2,PTPN6,HCK
1.820e-03	-6.31	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	11	16828	45	ARHGAP15,SKAP1,DOCK1,DOCK10,PREX1,IPCEF1,ELMO1,AKAP13,DOCK2,WDFY4,VAV3
1.820e-03	-6.31	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	11	16828	45	DOCK1,ARHGAP15,SKAP1,VAV3,AKAP13,IPCEF1,ELMO1,DOCK10,PREX1,WDFY4,DOCK2
1.849e-03	-6.29	Factors involved in megakaryocyte development and platelet production	REACTOME pathways	R-HSA-983231	156	4	10285	35	DOCK8,DOCK2,DOCK1,DOCK10
1.875e-03	-6.28	human chr7p14.2-p14.1	chromosome location	human chr7p14.2-p14.1	1	1	26134	49	ELMO1
1.875e-03	-6.28	human chr2q22.2-q22.3	chromosome location	human chr2q22.2-q22.3	1	1	26134	49	ARHGAP15
1.886e-03	-6.27	negative regulation of T cell apoptotic process	biological process	GO:0070233	24	2	18204	49	HIF1A,DOCK8
1.886e-03	-6.27	positive regulation of macrophage cytokine production	biological process	GO:0060907	24	2	18204	49	PLCG2,CD74
1.916e-03	-6.26	Osteoclast differentiation	KEGG pathways	ko04380	129	4	7161	30	CSF1R,PLCG2,BLNK,SPI1
1.916e-03	-6.26	Osteoclast differentiation	KEGG pathways	hsa04380	129	4	7161	30	SPI1,BLNK,CSF1R,PLCG2
1.931e-03	-6.25	PTK2B (protein tyrosine kinase 2 beta)	protein interactions	2185	98	3	19454	49	PRKCD,TLN1,PTPN6
1.941e-03	-6.24	ARM-type_fold	interpro domains	IPR016024	338	5	18521	49	ELMO1,WDFY4,DOCK1,DOCK8,DOCK2
1.945e-03	-6.24	positive regulation of leukocyte chemotaxis	biological process	GO:0002690	92	3	18204	49	CSF1R,IL6R,CD74
1.950e-03	-6.24	mouth	COSMIC cancer mutations	mouth	9004	34	16828	45	DOCK2,ADCY7,TBXAS1,PARVG,CD74,PTPN6,PREX1,ELMO1,GMIP,RGS14,ARHGAP33,GAB1,P2RY2,TBC1D8,RHBDF2,GIT2,CSF1R,WDFY4,PRKCD,APOE,PLCG2,DENND1B,MYO1F,DOCK10,AKAP13,IRF5,NEK6,VAV3,DOCK1,SBNO2,EHBP1L1,TLN1,HCK,DOCK8
1.999e-03	-6.22	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	4	18204	49	CD74,P2RY6,CSF1R,APOE
2.031e-03	-6.20	DH_2	prosite domains	PS50010	70	3	12186	44	VAV3,PREX1,AKAP13
2.045e-03	-6.19	actin cytoskeleton	cellular component	GO:0015629	520	6	19108	49	PARVG,HCK,MYO1F,FYB1,AKAP13,ARHGAP33
2.047e-03	-6.19	Fc-epsilon receptor signaling pathway	biological process	GO:0038095	25	2	18204	49	PLCG2,VAV3
2.066e-03	-6.18	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	27	16828	45	P2RY2,ARHGAP33,SKAP1,ARHGAP15,RGS14,ELMO1,IPCEF1,PREX1,PARVG,DOCK2,ADCY7,STAT6,TLN1,HCK,DOCK8,DOCK1,IRF5,NEK6,AKAP13,DOCK10,MYO1F,P2RY6,PRKCD,PLCG2,CSF1R,WDFY4,TBC1D8
2.066e-03	-6.18	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	27	16828	45	DOCK8,TLN1,HCK,STAT6,DOCK1,NEK6,IRF5,AKAP13,DOCK10,MYO1F,PLCG2,PRKCD,P2RY6,WDFY4,CSF1R,TBC1D8,P2RY2,ARHGAP15,SKAP1,ARHGAP33,RGS14,IPCEF1,ELMO1,PREX1,PARVG,ADCY7,DOCK2
2.069e-03	-6.18	negative regulation of protein serine/threonine kinase activity	biological process	GO:0071901	94	3	18204	49	RGS14,PRKCD,APOE
2.095e-03	-6.17	OLIG1 (oligodendrocyte transcription factor 1)	protein interactions	116448	27	2	19454	49	HCK,PTPN6
2.095e-03	-6.17	CD72 (CD72 molecule)	protein interactions	971	27	2	19454	49	BLNK,PTPN6
2.137e-03	-6.15	Calponin-like domain	gene3d domains	1.10.418.10	79	3	14470	47	VAV3,PARVG,EHBP1L1
2.141e-03	-6.15	regulation of cell-cell adhesion	biological process	GO:0022407	500	6	18204	49	CD74,PRKCD,SKAP1,SPI1,PTPN6,DOCK8
2.141e-03	-6.15	Cell death signalling via NRAGE, NRIF and NADE	REACTOME pathways	R-HSA-204998	76	3	10285	35	VAV3,AKAP13,PREX1
2.149e-03	-6.14	negative regulation of cell-cell adhesion	biological process	GO:0022408	203	4	18204	49	SPI1,PTPN6,PRKCD,CD74
2.164e-03	-6.14	GRAP2 (GRB2 related adaptor protein 2)	protein interactions	9402	102	3	19454	49	BLNK,CSF1R,GAB1
2.164e-03	-6.14	DOCK5 (dedicator of cytokinesis 5)	protein interactions	80005	102	3	19454	49	ELMO1,DOCK1,GIT2
2.197e-03	-6.12	negative regulation of response to wounding	biological process	GO:1903035	96	3	18204	49	PTPN6,PRKCD,APOE
2.197e-03	-6.12	immunoglobulin mediated immune response	biological process	GO:0016064	96	3	18204	49	CD74,STAT6,PRKCD
2.203e-03	-6.12	programmed cell death	biological process	GO:0012501	1087	9	18204	49	PLCG2,HIF1A,IL6R,SPI1,DOCK1,PRKCD,GSDME,ELMO1,NEK6
2.250e-03	-6.10	regulation of lymphocyte activation	biological process	GO:0051249	505	6	18204	49	CD74,STAT6,SPI1,PTPN6,DOCK8,VAV3
2.259e-03	-6.09	cell death	biological process	GO:0008219	1091	9	18204	49	GSDME,NEK6,ELMO1,IL6R,HIF1A,PRKCD,DOCK1,SPI1,PLCG2
2.291e-03	-6.08	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	36	16828	45	P2RY2,ARHGAP15,SKAP1,GAB1,ARHGAP33,RGS14,ELMO1,PIK3R5,PREX1,PTPN6,PARVG,ADCY7,DOCK2,DOCK8,TLN1,HCK,STAT6,DOCK1,VAV3,HIF1A,IRF5,NEK6,SPI1,AKAP13,IL6R,MYO1F,DOCK10,DENND1B,PLCG2,PRKCD,P2RY6,WDFY4,CSF1R,GIT2,RHBDF2,TBC1D8
2.297e-03	-6.08	CH	smart domains	SM00033	66	3	9717	39	EHBP1L1,VAV3,PARVG
2.300e-03	-6.07	regulation of cell population proliferation	biological process	GO:0042127	1790	12	18204	49	CSF1R,GSDME,TBC1D8,HCK,STAT6,APOE,VAV3,P2RY6,HIF1A,IL6R,CD74,PTPN6
2.319e-03	-6.07	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	36	16828	45	PIK3R5,PREX1,PTPN6,PARVG,ADCY7,DOCK2,P2RY2,ARHGAP15,SKAP1,GAB1,ARHGAP33,RGS14,ELMO1,IL6R,DOCK10,MYO1F,DENND1B,PLCG2,PRKCD,P2RY6,WDFY4,GIT2,CSF1R,RHBDF2,TBC1D8,DOCK8,HCK,TLN1,STAT6,DOCK1,VAV3,IRF5,HIF1A,NEK6,AKAP13,SPI1
2.387e-03	-6.04	cytokine production	biological process	GO:0001816	27	2	18204	49	HIF1A,IL6R
2.387e-03	-6.04	mature B cell differentiation involved in immune response	biological process	GO:0002313	27	2	18204	49	DOCK10,PLCG2
2.387e-03	-6.04	T cell lineage commitment	biological process	GO:0002360	27	2	18204	49	STAT6,IL6R
2.416e-03	-6.03	CNTF (ciliary neurotrophic factor)	protein interactions	1270	29	2	19454	49	APOE,IL6R
2.435e-03	-6.02	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	27	16828	45	TLN1,HCK,DOCK8,SBNO2,NEK6,IRF5,AKAP13,DOCK10,MYO1F,PLCG2,APOE,PRKCD,GIT2,WDFY4,RHBDF2,TBC1D8,P2RY2,ARHGAP33,RGS14,GMIP,ELMO1,PREX1,PTPN6,CD74,TBXAS1,ADCY7,DOCK2
2.447e-03	-6.01	EGF receptor (ErbB1) signaling pathway	Pathway Interaction DB	erbb1_receptor_proximal_pathway	25	3	2226	25	PTPN6,GAB1,TLN1
2.456e-03	-6.01	JPH1 (junctophilin 1)	protein interactions	56704	225	4	19454	49	RHBDF2,SKAP1,CSF1R,TBC1D8
2.467e-03	-6.00	positive regulation of interleukin-6 production	biological process	GO:0032755	100	3	18204	49	PLCG2,IL6R,CD74
2.479e-03	-6.00	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	7	18204	49	CSF1R,CD74,IL6R,PRKCD,P2RY6,PIK3R5,PLCG2
2.479e-03	-6.00	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	7	18204	49	CSF1R,PRKCD,P2RY6,CD74,IL6R,PIK3R5,PLCG2
2.483e-03	-6.00	Integrin-mediated Cell Adhesion	WikiPathways	WP185	103	4	5310	30	TLN1,VAV3,GIT2,DOCK1
2.494e-03	-5.99	regulation of cellular component size	biological process	GO:0032535	352	5	18204	49	PREX1,VAV3,APOE,PRKCD,HCK
2.495e-03	-5.99	PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)	protein interactions	5296	226	4	19454	49	HCK,GAB1,CSF1R,SKAP1
2.502e-03	-5.99	RhoGEF	smart domains	SM00325	68	3	9717	39	AKAP13,VAV3,PREX1
2.519e-03	-5.98	Prkch (protein kinase C, eta)	protein interactions	81749	1	1	19454	49	AKAP13
2.519e-03	-5.98	Bmal1 (basic helix-loop-helix ARNT like 1)	protein interactions	11865	1	1	19454	49	HIF1A
2.519e-03	-5.98	NTA1 (amidase)	protein interactions	853525	1	1	19454	49	DOCK8
2.519e-03	-5.98	EUC1 (Euc1p)	protein interactions	855138	1	1	19454	49	DOCK8
2.538e-03	-5.98	B cell mediated immunity	biological process	GO:0019724	101	3	18204	49	CD74,STAT6,PRKCD
2.562e-03	-5.97	DH_1	prosite domains	PS00741	21	2	12186	44	PREX1,VAV3
2.564e-03	-5.97	NOS2-CD74 complex	cellular component	GO:0035693	1	1	19108	49	CD74
2.566e-03	-5.97	purinergic nucleotide receptor signaling pathway	biological process	GO:0035590	28	2	18204	49	P2RY2,P2RY6
2.584e-03	-5.96	PECAM1 (platelet and endothelial cell adhesion molecule 1)	protein interactions	5175	30	2	19454	49	PTPN6,HCK
2.584e-03	-5.96	CSF3R (colony stimulating factor 3 receptor)	protein interactions	1441	30	2	19454	49	PRKCD,HCK
2.598e-03	-5.95	MHC class II protein binding, via antigen binding groove	molecular function	GO:0042658	1	1	18094	47	CD74
2.598e-03	-5.95	metal chelating activity	molecular function	GO:0046911	1	1	18094	47	APOE
2.598e-03	-5.95	ciliary neurotrophic factor binding	molecular function	GO:0070119	1	1	18094	47	IL6R
2.601e-03	-5.95	negative regulation of cell activation	biological process	GO:0050866	214	4	18204	49	APOE,PRKCD,PTPN6,CD74
2.610e-03	-5.95	regulation of phagocytosis	biological process	GO:0050764	102	3	18204	49	HCK,PLCG2,DOCK2
2.629e-03	-5.94	regulation of cytoskeleton organization	biological process	GO:0051493	521	6	18204	49	PREX1,CARMIL3,CSF1R,PRKCD,AKAP13,HCK
2.635e-03	-5.94	P2YPURNOCPTR	prints domains	PR01157	24	2	5227	17	P2RY2,P2RY6
2.637e-03	-5.94	CREBBP (CREB binding protein)	protein interactions	1387	557	6	19454	49	SPI1,PRKCD,STAT6,HIF1A,IRF5,HCK
2.646e-03	-5.93	RGS14_RGS	interpro domains	IPR037881	1	1	18521	49	RGS14
2.646e-03	-5.93	SKAP1_SH3	interpro domains	IPR035765	1	1	18521	49	SKAP1
2.646e-03	-5.93	HIF-1_alpha	interpro domains	IPR001321	1	1	18521	49	HIF1A
2.646e-03	-5.93	MHC_II-assoc_invar_chain	interpro domains	IPR022339	1	1	18521	49	CD74
2.646e-03	-5.93	HCK_SH2	interpro domains	IPR035851	1	1	18521	49	HCK
2.646e-03	-5.93	RBD2_RGS14	interpro domains	IPR046993	1	1	18521	49	RGS14
2.646e-03	-5.93	VAV3_SH3_2	interpro domains	IPR035734	1	1	18521	49	VAV3
2.646e-03	-5.93	nPKC_delta	interpro domains	IPR034667	1	1	18521	49	PRKCD
2.646e-03	-5.93	DOCK1_C2	interpro domains	IPR047026	1	1	18521	49	DOCK1
2.646e-03	-5.93	VAV3_SH3_1	interpro domains	IPR047015	1	1	18521	49	VAV3
2.646e-03	-5.93	STAT6_C	interpro domains	IPR028187	1	1	18521	49	STAT6
2.646e-03	-5.93	PLCgamma2_SH3	interpro domains	IPR035723	1	1	18521	49	PLCG2
2.646e-03	-5.93	CSF-1_receptor	interpro domains	IPR030658	1	1	18521	49	CSF1R
2.646e-03	-5.93	MHCII_invariant_trimer_sf	interpro domains	IPR036613	1	1	18521	49	CD74
2.646e-03	-5.93	P2Y6_rcpt	interpro domains	IPR001973	1	1	18521	49	P2RY6
2.646e-03	-5.93	PKC_delta	interpro domains	IPR027436	1	1	18521	49	PRKCD
2.646e-03	-5.93	DHR2_DOCK2	interpro domains	IPR026799	1	1	18521	49	DOCK2
2.646e-03	-5.93	FYB_hSH3	interpro domains	IPR035540	1	1	18521	49	FYB1
2.646e-03	-5.93	MHC_II-assoc_invariant_trimer	interpro domains	IPR011988	1	1	18521	49	CD74
2.646e-03	-5.93	TBC1D8_PH-GRAM1	interpro domains	IPR036009	1	1	18521	49	TBC1D8
2.646e-03	-5.93	VAV3_SH2	interpro domains	IPR035881	1	1	18521	49	VAV3
2.646e-03	-5.93	RBD1_RGS14	interpro domains	IPR046992	1	1	18521	49	RGS14
2.646e-03	-5.93	P2Y2_rcpt	interpro domains	IPR000356	1	1	18521	49	P2RY2
2.646e-03	-5.93	CD74_antigen	interpro domains	IPR043530	1	1	18521	49	CD74
2.646e-03	-5.93	TBC1D8_PH-GRAM2	interpro domains	IPR036016	1	1	18521	49	TBC1D8
2.646e-03	-5.93	STAT6_SH2	interpro domains	IPR035857	1	1	18521	49	STAT6
2.646e-03	-5.93	MHC_II-assoc_invar/CLIP_MHC-bd	interpro domains	IPR015386	1	1	18521	49	CD74
2.682e-03	-5.92	Signaling events mediated by focal adhesion kinase	Pathway Interaction DB	fak_pathway	54	4	2226	25	DOCK1,TLN1,ELMO1,GIT2
2.682e-03	-5.92	PDGFR-beta signaling pathway	Pathway Interaction DB	pdgfrbpathway	54	4	2226	25	HIF1A,GAB1,HCK,PRKCD
2.692e-03	-5.92	cellular response to pyrimidine ribonucleotide	biological process	GO:1905835	1	1	18204	49	P2RY6
2.692e-03	-5.92	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of glucosylceramide catabolic process	biological process	GO:2000753	1	1	18204	49	PRKCD
2.692e-03	-5.92	memory T cell proliferation	biological process	GO:0061485	1	1	18204	49	DOCK8
2.692e-03	-5.92	response to pyrimidine ribonucleotide	biological process	GO:1905834	1	1	18204	49	P2RY6
2.692e-03	-5.92	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	49	APOE
2.692e-03	-5.92	zygote asymmetric cell division	biological process	GO:0010070	1	1	18204	49	RGS14
2.692e-03	-5.92	positive regulation of phospholipid scramblase activity	biological process	GO:1900163	1	1	18204	49	PRKCD
2.692e-03	-5.92	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	49	APOE
2.692e-03	-5.92	regulation of phospholipid scramblase activity	biological process	GO:1900161	1	1	18204	49	PRKCD
2.692e-03	-5.92	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	49	APOE
2.692e-03	-5.92	macrophage migration inhibitory factor signaling pathway	biological process	GO:0035691	1	1	18204	49	CD74
2.692e-03	-5.92	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	49	APOE
2.692e-03	-5.92	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	49	APOE
2.692e-03	-5.92	cellular response to interleukin-11	biological process	GO:0071348	1	1	18204	49	SBNO2
2.751e-03	-5.90	myoblast fusion	biological process	GO:0007520	29	2	18204	49	DOCK2,DOCK1
2.754e-03	-5.89	MHCassoc_trimer	pfam domains	PF08831	1	1	17795	49	CD74
2.754e-03	-5.89	STAT6_C	pfam domains	PF14596	1	1	17795	49	STAT6
2.754e-03	-5.89	MHC2-interact	pfam domains	PF09307	1	1	17795	49	CD74
2.758e-03	-5.89	CSF2RB (colony stimulating factor 2 receptor subunit beta)	protein interactions	1439	31	2	19454	49	PTPN6,HCK
2.829e-03	-5.87	JAK1 (Janus kinase 1)	protein interactions	3716	234	4	19454	49	PLCG2,STAT6,GAB1,PTPN6
2.836e-03	-5.87	negative regulation of immune system process	biological process	GO:0002683	529	6	18204	49	CD74,STAT6,HCK,SPI1,PTPN6,RHBDF2
2.848e-03	-5.86	adaptive immune response	biological process	GO:0002250	363	5	18204	49	SKAP1,PRKCD,STAT6,IL6R,CD74
2.921e-03	-5.84	regulation of cell-substrate adhesion	biological process	GO:0010810	221	4	18204	49	PREX1,SKAP1,DOCK1,TLN1
2.921e-03	-5.84	leukocyte mediated immunity	biological process	GO:0002443	221	4	18204	49	PTPN6,PRKCD,STAT6,CD74
2.935e-03	-5.83	Phospholipase D signaling pathway	KEGG pathways	ko04072	145	4	7161	30	PIK3R5,PLCG2,GAB1,ADCY7
2.935e-03	-5.83	Phospholipase D signaling pathway	KEGG pathways	hsa04072	145	4	7161	30	GAB1,ADCY7,PIK3R5,PLCG2
2.937e-03	-5.83	CC2D1B (coiled-coil and C2 domain containing 1B)	protein interactions	200014	32	2	19454	49	SKAP1,TLN1
2.937e-03	-5.83	AAMDC (adipogenesis associated Mth938 domain containing)	protein interactions	28971	32	2	19454	49	VAV3,GMIP
2.971e-03	-5.82	regulation of response to biotic stimulus	biological process	GO:0002831	534	6	18204	49	GSDME,APOE,HCK,PTPN6,PLCG2,SPI1
3.080e-03	-5.78	CH	prosite domains	PS50021	81	3	12186	44	PARVG,VAV3,EHBP1L1
3.112e-03	-5.77	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	5	18521	49	NRK,CSF1R,HCK,NEK6,PRKCD
3.113e-03	-5.77	cell population proliferation	biological process	GO:0008283	726	7	18204	49	CSF1R,STAT6,HIF1A,PRKCD,DOCK8,DOCK2,PTPN6
3.122e-03	-5.77	ELMO3 (engulfment and cell motility 3)	protein interactions	79767	33	2	19454	49	DOCK1,ELMO1
3.140e-03	-5.76	neutrophil activation	biological process	GO:0042119	31	2	18204	49	PREX1,PRKCD
3.140e-03	-5.76	B cell homeostasis	biological process	GO:0001782	31	2	18204	49	DOCK10,HIF1A
3.186e-03	-5.75	positive regulation of cellular biosynthetic process	biological process	GO:0031328	2652	15	18204	49	PLCG2,IRF5,APOE,SBNO2,STAT6,DENND1B,CSF1R,BLNK,SPI1,SKAP1,PRKCD,P2RY6,HIF1A,CD74,IL6R
3.212e-03	-5.74	cell junction	cellular component	GO:0030054	2224	13	19108	49	SKAP1,APOE,FYB1,GIT2,RGS14,DOCK10,PRKCD,PARVG,HCK,GAB1,TLN1,PTPN6,ARHGAP33
3.217e-03	-5.74	KRTAP10-8 (keratin associated protein 10-8)	protein interactions	386681	399	5	19454	49	HCK,DOCK2,ARHGAP33,NEK6,P2RY6
3.228e-03	-5.74	transcription coregulator binding	molecular function	GO:0001221	114	3	18094	47	STAT6,NEK6,HIF1A
3.248e-03	-5.73	MHC class II-associated invariant chain, trimerisation domain	gene3d domains	1.10.870.10	1	1	14470	47	CD74
3.251e-03	-5.73	G alpha (12/13) signalling events	REACTOME pathways	R-HSA-416482	88	3	10285	35	VAV3,PREX1,AKAP13
3.252e-03	-5.73	CD74ANTIGEN	prints domains	PR01990	1	1	5227	17	CD74
3.252e-03	-5.73	P2Y2PRNOCPTR	prints domains	PR00594	1	1	5227	17	P2RY2
3.252e-03	-5.73	HYPOXIAIF1A	prints domains	PR01080	1	1	5227	17	HIF1A
3.252e-03	-5.73	P2Y6PRNOCPTR	prints domains	PR01068	1	1	5227	17	P2RY6
3.312e-03	-5.71	ITGB7 (integrin subunit beta 7)	protein interactions	3695	34	2	19454	49	PRKCD,TLN1
3.344e-03	-5.70	lipopolysaccharide-mediated signaling pathway	biological process	GO:0031663	32	2	18204	49	PLCG2,HCK
3.345e-03	-5.70	actin cytoskeleton organization	biological process	GO:0030036	547	6	18204	49	PREX1,ELMO1,DOCK2,TLN1,MYO1F,PARVG
3.406e-03	-5.68	localization within membrane	biological process	GO:0051668	549	6	18204	49	DENND1B,SKAP1,FYB1,APOE,RHBDF2,DOCK2
3.421e-03	-5.68	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	9	16828	45	HCK,PRKCD,ARHGAP15,GAB1,BLNK,NEK6,CSF1R,DOCK2,SPI1
3.421e-03	-5.68	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	9	16828	45	DOCK2,SPI1,NEK6,CSF1R,BLNK,GAB1,PRKCD,ARHGAP15,HCK
3.423e-03	-5.68	regulation of leukocyte migration	biological process	GO:0002685	231	4	18204	49	IL6R,CD74,DOCK8,CSF1R
3.474e-03	-5.66	Role of phospholipids in phagocytosis	REACTOME pathways	R-HSA-2029485	26	2	10285	35	PRKCD,PLCG2
3.484e-03	-5.66	SYK (spleen associated tyrosine kinase)	protein interactions	6850	248	4	19454	49	PLCG2,GAB1,PTPN6,BLNK
3.484e-03	-5.66	MET (MET proto-oncogene, receptor tyrosine kinase)	protein interactions	4233	248	4	19454	49	GAB1,HCK,PLCG2,VAV3
3.507e-03	-5.65	Mbp (myelin basic protein)	protein interactions	17196	35	2	19454	49	FYB1,HCK
3.553e-03	-5.64	negative regulation of inflammatory response to antigenic stimulus	biological process	GO:0002862	33	2	18204	49	HCK,RHBDF2
3.553e-03	-5.64	mature B cell differentiation	biological process	GO:0002335	33	2	18204	49	PLCG2,DOCK10
3.649e-03	-5.61	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	34	16828	45	PREX1,PIK3R5,PARVG,PTPN6,DOCK2,ADCY7,ARHGAP33,GAB1,SKAP1,ARHGAP15,BLNK,RGS14,MYO1F,DOCK10,IL6R,PRKCD,PLCG2,APOE,CSF1R,GIT2,WDFY4,STAT6,TLN1,HCK,DOCK8,DOCK1,SBNO2,EHBP1L1,HIF1A,IRF5,NEK6,VAV3,AKAP13,SPI1
3.721e-03	-5.59	inflammatory response	biological process	GO:0006954	559	6	18204	49	IRF5,BLNK,CSF1R,HIF1A,HCK,IL6R
3.742e-03	-5.59	nef (Nef)	protein interactions	156110	802	7	19454	49	ELMO1,CD74,PRKCD,ADCY7,CSF1R,DOCK2,HCK
3.744e-03	-5.59	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	REACTOME pathways	R-HSA-8849471	27	2	10285	35	ELMO1,DOCK1
3.756e-03	-5.58	positive regulation of biosynthetic process	biological process	GO:0009891	2697	15	18204	49	P2RY6,PRKCD,SKAP1,SPI1,IL6R,CD74,HIF1A,BLNK,CSF1R,SBNO2,DENND1B,STAT6,IRF5,APOE,PLCG2
3.769e-03	-5.58	regulation of B cell differentiation	biological process	GO:0045577	34	2	18204	49	PTPN6,SPI1
3.783e-03	-5.58	G protein-coupled receptor signaling pathway	biological process	GO:0007186	1178	9	18204	49	PREX1,P2RY2,P2RY6,PIK3R5,APOE,ADCY7,RGS14,PTPN6,AKAP13
3.796e-03	-5.57	Bacterial invasion of epithelial cells	KEGG pathways	ko05100	76	3	7161	30	GAB1,ELMO1,DOCK1
3.796e-03	-5.57	Bacterial invasion of epithelial cells	KEGG pathways	hsa05100	76	3	7161	30	ELMO1,DOCK1,GAB1
3.858e-03	-5.56	receptor complex	cellular component	GO:0043235	409	5	19108	49	IL6R,CD74,CSF1R,SKAP1,PTPN6
3.887e-03	-5.55	positive regulation of response to external stimulus	biological process	GO:0032103	564	6	18204	49	PLCG2,CSF1R,SPI1,HCK,IL6R,CD74
3.913e-03	-5.54	CARD11 (caspase recruitment domain family member 11)	protein interactions	84433	37	2	19454	49	FYB1,PRKCD
3.916e-03	-5.54	Interferon gamma signaling	REACTOME pathways	R-HSA-877300	94	3	10285	35	PRKCD,IRF5,PTPN6
3.933e-03	-5.54	UQCRH (ubiquinol-cytochrome c reductase hinge protein)	protein interactions	7388	126	3	19454	49	GSDME,P2RY6,APOE
3.933e-03	-5.54	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-follicular_lymphoma	35	2	16828	45	RHBDF2,STAT6
3.990e-03	-5.52	granulocyte activation	biological process	GO:0036230	35	2	18204	49	PREX1,PRKCD
3.990e-03	-5.52	positive regulation of myeloid leukocyte cytokine production involved in immune response	biological process	GO:0061081	35	2	18204	49	CD74,PLCG2
4.023e-03	-5.52	CaM pathway	REACTOME pathways	R-HSA-111997	28	2	10285	35	PRKCD,ADCY7
4.023e-03	-5.52	Calmodulin induced events	REACTOME pathways	R-HSA-111933	28	2	10285	35	ADCY7,PRKCD
4.036e-03	-5.51	membrane organization	biological process	GO:0061024	761	7	18204	49	DOCK2,APOE,VAV3,ELMO1,NEK6,PRKCD,DOCK1
4.111e-03	-5.49	GAB2 (GRB2 associated binding protein 2)	protein interactions	9846	128	3	19454	49	PLCG2,PTPN6,GAB1
4.123e-03	-5.49	STK33 (serine/threonine kinase 33)	protein interactions	65975	38	2	19454	49	HCK,TLN1
4.127e-03	-5.49	pleura	COSMIC cancer mutations	pleura	4914	22	16828	45	ARHGAP15,GAB1,ARHGAP33,RGS14,PTPN6,PIK3R5,PREX1,DOCK1,TLN1,HCK,STAT6,AKAP13,SPI1,VAV3,HIF1A,NEK6,IRF5,PLCG2,PRKCD,IL6R,CSF1R,GIT2
4.137e-03	-5.49	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	20	16828	45	AKAP13,ELMO1,GMIP,VAV3,BLNK,ARHGAP33,DOCK1,HCK,TLN1,P2RY2,DOCK8,DOCK2,TBC1D8,RHBDF2,CSF1R,WDFY4,MYO1F,DOCK10,PREX1,PIK3R5
4.163e-03	-5.48	regulation of leukocyte activation	biological process	GO:0002694	572	6	18204	49	PTPN6,DOCK8,SPI1,CD74,STAT6,VAV3
4.200e-03	-5.47	cytoplasm	cellular component	GO:0005737	12081	40	19108	49	ARHGAP33,PREX1,TLN1,DOCK1,RHBDF2,NEK6,DOCK2,PARVG,IPCEF1,ARHGAP15,RGS14,CD74,IRF5,WDFY4,FYB1,SKAP1,GSDME,AKAP13,HIF1A,PLCG2,DENND1B,GAB1,PTPN6,TBXAS1,GMIP,MYO1F,EHBP1L1,HCK,CARMIL3,PRKCD,DOCK10,STAT6,ELMO1,NRK,PIK3R5,ARHGAP27,VAV3,DOCK8,BLNK,APOE
4.218e-03	-5.47	phagocytosis, engulfment	biological process	GO:0006911	36	2	18204	49	ELMO1,DOCK1
4.234e-03	-5.46	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	hsa01521	79	3	7161	30	IL6R,GAB1,PLCG2
4.234e-03	-5.46	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	ko01521	79	3	7161	30	PLCG2,IL6R,GAB1
4.234e-03	-5.46	positive regulation of protein phosphorylation	biological process	GO:0001934	574	6	18204	49	CSF1R,IL6R,CD74,PRKCD,PIK3R5,PLCG2
4.277e-03	-5.45	p75 NTR receptor-mediated signalling	REACTOME pathways	R-HSA-193704	97	3	10285	35	AKAP13,PREX1,VAV3
4.292e-03	-5.45	STAT3 (signal transducer and activator of transcription 3)	protein interactions	6774	427	5	19454	49	PRKCD,STAT6,HCK,IL6R,HIF1A
4.299e-03	-5.45	regulation of organelle organization	biological process	GO:0033043	1201	9	18204	49	AKAP13,HCK,HIF1A,TBC1D8,PRKCD,CSF1R,CARMIL3,NEK6,PREX1
4.322e-03	-5.44	regulation of leukocyte chemotaxis	biological process	GO:0002688	122	3	18204	49	CSF1R,CD74,IL6R
4.334e-03	-5.44	GPCR downstream signaling	REACTOME pathways	R-HSA-388396	974	9	10285	35	RGS14,P2RY6,P2RY2,ADCY7,PRKCD,VAV3,PIK3R5,AKAP13,PREX1
4.357e-03	-5.44	signaling receptor binding	molecular function	GO:0005102	1493	10	18094	47	TLN1,APOE,VAV3,DOCK2,BLNK,IL6R,P2RY2,HCK,CD74,FYB1
4.451e-03	-5.41	regulation of macrophage cytokine production	biological process	GO:0010935	37	2	18204	49	PLCG2,CD74
4.523e-03	-5.40	positive regulation of cell-substrate adhesion	biological process	GO:0010811	124	3	18204	49	PREX1,SKAP1,DOCK1
4.523e-03	-5.40	positive regulation of lipid metabolic process	biological process	GO:0045834	124	3	18204	49	CD74,PRKCD,APOE
4.575e-03	-5.39	PLD2 (phospholipase D2)	protein interactions	5338	133	3	19454	49	PRKCD,SKAP1,HIF1A
4.610e-03	-5.38	Ca-dependent events	REACTOME pathways	R-HSA-111996	30	2	10285	35	ADCY7,PRKCD
4.610e-03	-5.38	FCERI mediated Ca+2 mobilization	REACTOME pathways	R-HSA-2871809	30	2	10285	35	VAV3,PLCG2
4.626e-03	-5.38	mammary gland development	biological process	GO:0030879	125	3	18204	49	CSF1R,STAT6,HIF1A
4.691e-03	-5.36	unsaturated fatty acid biosynthetic process	biological process	GO:0006636	38	2	18204	49	TBXAS1,CD74
4.852e-03	-5.33	cellular process	biological process	GO:0009987	14996	47	18204	49	SPI1,NEK6,ARHGAP15,DOCK10,DOCK8,ARHGAP33,GMIP,IRF5,ADCY7,FYB1,VAV3,AKAP13,RGS14,PTPN6,TBXAS1,GAB1,CARMIL3,PLCG2,GIT2,SKAP1,CD74,HIF1A,MYO1F,BLNK,IPCEF1,PIK3R5,STAT6,ELMO1,GSDME,CSF1R,WDFY4,P2RY6,PRKCD,P2RY2,DOCK1,IL6R,PREX1,DOCK2,ARHGAP27,SBNO2,DENND1B,HCK,TLN1,PARVG,NRK,RHBDF2,APOE
4.853e-03	-5.33	VEGFA-VEGFR2 Pathway	REACTOME pathways	R-HSA-4420097	330	5	10285	35	ELMO1,TLN1,PRKCD,DOCK1,VAV3
4.869e-03	-5.32	NEFL (neurofilament light chain)	protein interactions	4747	136	3	19454	49	NEK6,GMIP,SKAP1
4.881e-03	-5.32	brainstem	COSMIC cancer mutations	brainstem	3102	16	16828	45	PTPN6,ARHGAP27,PREX1,DOCK10,DOCK2,CSF1R,GIT2,WDFY4,GAB1,DOCK1,ARHGAP15,SKAP1,AKAP13,ELMO1,VAV3,BLNK
4.918e-03	-5.31	cell differentiation	biological process	GO:0030154	3645	18	18204	49	DOCK10,DOCK2,BLNK,PTPN6,AKAP13,PREX1,SPI1,DOCK1,HIF1A,CD74,IL6R,APOE,PLCG2,GSDME,CSF1R,SBNO2,HCK,STAT6
4.923e-03	-5.31	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	13	16828	45	CSF1R,WDFY4,ADCY7,DOCK2,PTPN6,RGS14,BLNK,IPCEF1,ELMO1,DOCK8,DOCK1,SKAP1,SBNO2
4.929e-03	-5.31	positive regulation of protein kinase activity	biological process	GO:0045860	256	4	18204	49	PIK3R5,CSF1R,IL6R,PRKCD
4.936e-03	-5.31	long-term memory	biological process	GO:0007616	39	2	18204	49	RGS14,APOE
4.936e-03	-5.31	regulation of T cell apoptotic process	biological process	GO:0070232	39	2	18204	49	HIF1A,DOCK8
4.963e-03	-5.31	cellular developmental process	biological process	GO:0048869	3648	18	18204	49	AKAP13,PTPN6,DOCK2,DOCK10,BLNK,HIF1A,IL6R,CD74,SPI1,DOCK1,PREX1,PLCG2,APOE,STAT6,HCK,SBNO2,CSF1R,GSDME
5.031e-03	-5.29	KIR2DL5A (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A)	protein interactions	57292	2	1	19454	49	PTPN6
5.031e-03	-5.29	Per1 (period circadian clock 1)	protein interactions	18626	2	1	19454	49	HIF1A
5.031e-03	-5.29	HIF1A-AS2 (HIF1A antisense RNA 2)	protein interactions	100750247	2	1	19454	49	HIF1A
5.031e-03	-5.29	MPIG6B (megakaryocyte and platelet inhibitory receptor G6b)	protein interactions	80739	2	1	19454	49	PTPN6
5.031e-03	-5.29	CUZD1 (CUB and zona pellucida like domains 1)	protein interactions	50624	2	1	19454	49	PTPN6
5.031e-03	-5.29	Siglece (sialic acid binding Ig-like lectin E)	protein interactions	83382	2	1	19454	49	PTPN6
5.031e-03	-5.29	IGHE (immunoglobulin heavy constant epsilon)	protein interactions	3497	2	1	19454	49	STAT6
5.031e-03	-5.29	Arnt (aryl hydrocarbon receptor nuclear translocator)	protein interactions	11863	2	1	19454	49	HIF1A
5.062e-03	-5.29	defense response to other organism	biological process	GO:0098542	1006	8	18204	49	HCK,CD74,IL6R,PRKCD,CSF1R,PTPN6,PLCG2,IRF5
5.085e-03	-5.28	central_nervous_system-brain-glioma-astrocytoma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_II	420	5	16828	45	SBNO2,RGS14,WDFY4,PREX1,TLN1
5.122e-03	-5.27	chylomicron remnant	cellular component	GO:0034360	2	1	19108	49	APOE
5.122e-03	-5.27	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	49	APOE
5.122e-03	-5.27	CSF1-CSF1R complex	cellular component	GO:1990682	2	1	19108	49	CSF1R
5.122e-03	-5.27	macrophage migration inhibitory factor receptor complex	cellular component	GO:0035692	2	1	19108	49	CD74
5.160e-03	-5.27	B cell differentiation	biological process	GO:0030183	130	3	18204	49	BLNK,DOCK10,PLCG2
5.187e-03	-5.26	prostaglandin metabolic process	biological process	GO:0006693	40	2	18204	49	TBXAS1,CD74
5.188e-03	-5.26	G protein-coupled UDP receptor activity	molecular function	GO:0045029	2	1	18094	47	P2RY6
5.188e-03	-5.26	interleukin-6 receptor activity	molecular function	GO:0004915	2	1	18094	47	IL6R
5.188e-03	-5.26	macrophage migration inhibitory factor binding	molecular function	GO:0035718	2	1	18094	47	CD74
5.188e-03	-5.26	interleukin-6 binding	molecular function	GO:0019981	2	1	18094	47	IL6R
5.188e-03	-5.26	macrophage colony-stimulating factor receptor activity	molecular function	GO:0005011	2	1	18094	47	CSF1R
5.188e-03	-5.26	thromboxane-A synthase activity	molecular function	GO:0004796	2	1	18094	47	TBXAS1
5.241e-03	-5.25	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	49	HCK,CSF1R,NEK6
5.254e-03	-5.25	ITGA1 (integrin subunit alpha 1)	protein interactions	3672	43	2	19454	49	TLN1,PTPN6
5.284e-03	-5.24	PIK3R5/6	interpro domains	IPR019522	2	1	18521	49	PIK3R5
5.284e-03	-5.24	SNO	interpro domains	IPR026741	2	1	18521	49	SBNO2
5.284e-03	-5.24	SNO_AAA	interpro domains	IPR039187	2	1	18521	49	SBNO2
5.284e-03	-5.24	Talin_R4	interpro domains	IPR049108	2	1	18521	49	TLN1
5.284e-03	-5.24	GSDME	interpro domains	IPR042377	2	1	18521	49	GSDME
5.284e-03	-5.24	PLC-gamma_C-SH2	interpro domains	IPR035023	2	1	18521	49	PLCG2
5.284e-03	-5.24	GIT-like	interpro domains	IPR047161	2	1	18521	49	GIT2
5.284e-03	-5.24	GIT1/2_CC	interpro domains	IPR032352	2	1	18521	49	GIT2
5.284e-03	-5.24	Tyr_Pase_non-rcpt_typ-6/11	interpro domains	IPR012152	2	1	18521	49	PTPN6
5.284e-03	-5.24	GIT1_C	interpro domains	IPR022018	2	1	18521	49	GIT2
5.284e-03	-5.24	Ie/If_SH3	interpro domains	IPR035507	2	1	18521	49	MYO1F
5.284e-03	-5.24	Vinculin-bd_dom	interpro domains	IPR015009	2	1	18521	49	TLN1
5.284e-03	-5.24	HIF-1_CTAD	interpro domains	IPR014887	2	1	18521	49	HIF1A
5.284e-03	-5.24	DOCK1_5_SH3	interpro domains	IPR047025	2	1	18521	49	DOCK1
5.284e-03	-5.24	SBNO_Helicase_C_dom	interpro domains	IPR026937	2	1	18521	49	SBNO2
5.284e-03	-5.24	Talin1/2-RS	interpro domains	IPR037438	2	1	18521	49	TLN1
5.284e-03	-5.24	iRhom1_2_N	interpro domains	IPR022241	2	1	18521	49	RHBDF2
5.284e-03	-5.24	Talin_cent_sf	interpro domains	IPR036476	2	1	18521	49	TLN1
5.284e-03	-5.24	SKAP_fam	interpro domains	IPR037781	2	1	18521	49	SKAP1
5.284e-03	-5.24	PLC-gamma_N-SH2	interpro domains	IPR035024	2	1	18521	49	PLCG2
5.284e-03	-5.24	PLC-gamma	interpro domains	IPR016279	2	1	18521	49	PLCG2
5.284e-03	-5.24	Talin_cent	interpro domains	IPR015224	2	1	18521	49	TLN1
5.284e-03	-5.24	GIT_SHD	interpro domains	IPR013724	2	1	18521	49	GIT2
5.290e-03	-5.24	growth factor binding	molecular function	GO:0019838	136	3	18094	47	CSF1R,RHBDF2,IL6R
5.369e-03	-5.23	Signaling by VEGF	REACTOME pathways	R-HSA-194138	338	5	10285	35	PRKCD,DOCK1,VAV3,ELMO1,TLN1
5.370e-03	-5.23	regulation of cellular component biogenesis	biological process	GO:0044087	1016	8	18204	49	APOE,TLN1,PLCG2,PREX1,HCK,SKAP1,TBC1D8,PRKCD
5.376e-03	-5.23	positive regulation of lipid transporter activity	biological process	GO:0110113	2	1	18204	49	PRKCD
5.376e-03	-5.23	hepatic immune response	biological process	GO:0002384	2	1	18204	49	IL6R
5.376e-03	-5.23	pro-T cell differentiation	biological process	GO:0002572	2	1	18204	49	SPI1
5.376e-03	-5.23	negative regulation of neutrophil degranulation	biological process	GO:0043314	2	1	18204	49	SPI1
5.376e-03	-5.23	inositol trisphosphate biosynthetic process	biological process	GO:0032959	2	1	18204	49	PLCG2
5.376e-03	-5.23	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	49	APOE
5.376e-03	-5.23	response to interleukin-11	biological process	GO:0071105	2	1	18204	49	SBNO2
5.376e-03	-5.23	regulation of sphingomyelin catabolic process	biological process	GO:2000754	2	1	18204	49	PRKCD
5.376e-03	-5.23	positive regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000448	2	1	18204	49	CD74
5.376e-03	-5.23	positive regulation of sphingomyelin catabolic process	biological process	GO:2000755	2	1	18204	49	PRKCD
5.382e-03	-5.22	NCAPD3 (non-SMC condensin II complex subunit D3)	protein interactions	23310	141	3	19454	49	CD74,SKAP1,P2RY6
5.397e-03	-5.22	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	265	4	16828	45	STAT6,HCK,BLNK,PLCG2
5.443e-03	-5.21	prostanoid metabolic process	biological process	GO:0006692	41	2	18204	49	TBXAS1,CD74
5.460e-03	-5.21	regulation of secretion	biological process	GO:0051046	605	6	18204	49	SPI1,P2RY2,HIF1A,CD74,RHBDF2,APOE
5.469e-03	-5.21	EPO signaling pathway	Pathway Interaction DB	epopathway	33	3	2226	25	PTPN6,GAB1,PLCG2
5.496e-03	-5.20	ASB9 (ankyrin repeat and SOCS box containing 9)	protein interactions	140462	44	2	19454	49	TLN1,PLCG2
5.496e-03	-5.20	HOXA10 (homeobox A10)	protein interactions	3206	44	2	19454	49	PTPN6,SPI1
5.497e-03	-5.20	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	49	PTPN6,PLCG2,P2RY6
5.497e-03	-5.20	positive regulation of adaptive immune response	biological process	GO:0002821	133	3	18204	49	SKAP1,STAT6,DENND1B
5.500e-03	-5.20	PI3K_1B_p101	pfam domains	PF10486	2	1	17795	49	PIK3R5
5.500e-03	-5.20	GIT_SHD	pfam domains	PF08518	2	1	17795	49	GIT2
5.500e-03	-5.20	iRhom1-2_N	pfam domains	PF12595	2	1	17795	49	RHBDF2
5.500e-03	-5.20	Helicase_C_4	pfam domains	PF13871	2	1	17795	49	SBNO2
5.500e-03	-5.20	GIT1_C	pfam domains	PF12205	2	1	17795	49	GIT2
5.500e-03	-5.20	HIF-1a_CTAD	pfam domains	PF08778	2	1	17795	49	HIF1A
5.500e-03	-5.20	Talin_middle	pfam domains	PF09141	2	1	17795	49	TLN1
5.500e-03	-5.20	Talin_R4	pfam domains	PF21692	2	1	17795	49	TLN1
5.500e-03	-5.20	PKC_C2	pfam domains	PF21494	2	1	17795	49	PRKCD
5.500e-03	-5.20	VBS	pfam domains	PF08913	2	1	17795	49	TLN1
5.500e-03	-5.20	AAA_34	pfam domains	PF13872	2	1	17795	49	SBNO2
5.500e-03	-5.20	GIT_CC	pfam domains	PF16559	2	1	17795	49	GIT2
5.564e-03	-5.19	response to stress	biological process	GO:0006950	3388	17	18204	49	RGS14,PTPN6,IPCEF1,BLNK,HIF1A,IL6R,CD74,SPI1,PRKCD,VAV3,TLN1,PLCG2,APOE,IRF5,STAT6,HCK,CSF1R
5.611e-03	-5.18	cytoskeleton organization	biological process	GO:0007010	1251	9	18204	49	ELMO1,PREX1,NEK6,PARVG,MYO1F,TLN1,RGS14,APOE,DOCK2
5.612e-03	-5.18	regulation of actin filament polymerization	biological process	GO:0030833	134	3	18204	49	PRKCD,HCK,PREX1
5.646e-03	-5.18	phosphatidylinositol binding	molecular function	GO:0035091	276	4	18094	47	TLN1,DENND1B,ARHGAP33,GSDME
5.704e-03	-5.17	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	12	16828	45	PIK3R5,P2RY6,PTPN6,PRKCD,PLCG2,CSF1R,STAT6,TLN1,P2RY2,DOCK8,GAB1,VAV3
5.704e-03	-5.17	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	12	16828	45	PIK3R5,PRKCD,PLCG2,P2RY6,PTPN6,CSF1R,P2RY2,DOCK8,STAT6,TLN1,GAB1,VAV3
5.706e-03	-5.17	COPG2 (COPI coat complex subunit gamma 2)	protein interactions	26958	144	3	19454	49	RHBDF2,CD74,P2RY6
5.713e-03	-5.16	regulation of protein serine/threonine kinase activity	biological process	GO:0071900	267	4	18204	49	PIK3R5,APOE,RGS14,PRKCD
5.721e-03	-5.16	negative regulation of response to external stimulus	biological process	GO:0032102	428	5	18204	49	HCK,PRKCD,PTPN6,APOE,RHBDF2
5.760e-03	-5.16	regulation of developmental process	biological process	GO:0050793	2540	14	18204	49	ARHGAP15,RGS14,PTPN6,PREX1,HIF1A,CD74,IL6R,SPI1,APOE,CSF1R,GAB1,ARHGAP33,HCK,STAT6
5.816e-03	-5.15	KDR (kinase insert domain receptor)	protein interactions	3791	145	3	19454	49	PLCG2,P2RY2,PTPN6
5.828e-03	-5.15	transcription coactivator binding	molecular function	GO:0001223	44	2	18094	47	HIF1A,STAT6
5.864e-03	-5.14	regulation of actin filament organization	biological process	GO:0110053	269	4	18204	49	HCK,PRKCD,CARMIL3,PREX1
5.890e-03	-5.13	response to wounding	biological process	GO:0009611	431	5	18204	49	TLN1,PTPN6,PLCG2,HIF1A,VAV3
5.895e-03	-5.13	DAG and IP3 signaling	REACTOME pathways	R-HSA-1489509	34	2	10285	35	ADCY7,PRKCD
5.941e-03	-5.13	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051896	270	4	18204	49	PTPN6,VAV3,PIK3R5,CSF1R
5.945e-03	-5.13	immunological synapse	cellular component	GO:0001772	45	2	19108	49	SKAP1,VAV3
5.952e-03	-5.12	actin filament-based process	biological process	GO:0030029	616	6	18204	49	PREX1,ELMO1,DOCK2,TLN1,PARVG,MYO1F
5.962e-03	-5.12	protein phosphatase binding	molecular function	GO:0019903	142	3	18094	47	STAT6,CSF1R,SKAP1
5.962e-03	-5.12	protein tyrosine kinase activity	molecular function	GO:0004713	142	3	18094	47	HCK,CSF1R,PRKCD
5.967e-03	-5.12	myeloid leukocyte migration	biological process	GO:0097529	137	3	18204	49	IL6R,PREX1,VAV3
5.974e-03	-5.12	T-helper cell differentiation	biological process	GO:0042093	43	2	18204	49	STAT6,IL6R
5.974e-03	-5.12	CD4-positive, alpha-beta T cell differentiation involved in immune response	biological process	GO:0002294	43	2	18204	49	STAT6,IL6R
5.974e-03	-5.12	positive regulation of substrate adhesion-dependent cell spreading	biological process	GO:1900026	43	2	18204	49	PREX1,DOCK1
5.974e-03	-5.12	positive regulation of interleukin-12 production	biological process	GO:0032735	43	2	18204	49	PLCG2,IRF5
5.994e-03	-5.12	adenoma	COSMIC cancer mutations	adenoma	2873	15	16828	45	DOCK8,HCK,TLN1,STAT6,SKAP1,HIF1A,IPCEF1,DOCK10,PREX1,PLCG2,APOE,PRKCD,WDFY4,TBC1D8,DOCK2
6.089e-03	-5.10	non-membrane spanning protein tyrosine kinase activity	molecular function	GO:0004715	45	2	18094	47	HCK,PRKCD
6.091e-03	-5.10	positive regulation of phosphorylation	biological process	GO:0042327	619	6	18204	49	PLCG2,PRKCD,CD74,IL6R,PIK3R5,CSF1R
6.211e-03	-5.08	regulation of cell shape	biological process	GO:0008360	139	3	18204	49	HCK,ARHGAP15,CSF1R
6.229e-03	-5.08	Interleukin-4 and 13 signaling	REACTOME pathways	R-HSA-6785807	111	3	10285	35	STAT6,HIF1A,IL6R
6.247e-03	-5.08	alpha-beta T cell differentiation involved in immune response	biological process	GO:0002293	44	2	18204	49	IL6R,STAT6
6.247e-03	-5.08	alpha-beta T cell activation involved in immune response	biological process	GO:0002287	44	2	18204	49	IL6R,STAT6
6.247e-03	-5.08	mammary gland morphogenesis	biological process	GO:0060443	44	2	18204	49	CSF1R,STAT6
6.364e-03	-5.06	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	5	10285	35	PRKCD,GAB1,TLN1,STAT6,ADCY7
6.400e-03	-5.05	regulation of localization	biological process	GO:0032879	2028	12	18204	49	CD74,HIF1A,P2RY6,PRKCD,SPI1,P2RY2,DOCK2,PTPN6,HCK,APOE,RHBDF2,PLCG2
6.426e-03	-5.05	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	6	18204	49	RGS14,BLNK,HCK,STAT6,CSF1R,GAB1
6.438e-03	-5.05	cytokine binding	molecular function	GO:0019955	146	3	18094	47	CD74,CSF1R,IL6R
6.461e-03	-5.04	positive regulation of chemotaxis	biological process	GO:0050921	141	3	18204	49	CD74,IL6R,CSF1R
6.486e-03	-5.04	-	gene3d domains	6.10.250.220	2	1	14470	47	SKAP1
6.500e-03	-5.04	PTK2 (protein tyrosine kinase 2)	protein interactions	5747	296	4	19454	49	TLN1,DOCK1,HCK,PTPN6
6.511e-03	-5.03	CYTH2 (cytohesin 2)	protein interactions	9266	48	2	19454	49	IPCEF1,DOCK1
6.527e-03	-5.03	negative regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050732	45	2	18204	49	PRKCD,PTPN6
6.527e-03	-5.03	plasma membrane invagination	biological process	GO:0099024	45	2	18204	49	DOCK1,ELMO1
6.527e-03	-5.03	negative regulation of blood coagulation	biological process	GO:0030195	45	2	18204	49	PRKCD,APOE
6.527e-03	-5.03	positive regulation of B cell proliferation	biological process	GO:0030890	45	2	18204	49	CD74,VAV3
6.588e-03	-5.02	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	49	APOE,CD74,P2RY6
6.592e-03	-5.02	PLC-gamma1 signalling	REACTOME pathways	R-HSA-167021	36	2	10285	35	ADCY7,PRKCD
6.592e-03	-5.02	EGFR interacts with phospholipase C-gamma	REACTOME pathways	R-HSA-212718	36	2	10285	35	PRKCD,ADCY7
6.645e-03	-5.01	Type II diabetes mellitus	WikiPathways	WP1584	22	2	5310	30	PIK3R5,PRKCD
6.660e-03	-5.01	positive regulation of leukocyte cell-cell adhesion	biological process	GO:1903039	279	4	18204	49	DOCK8,CD74,PTPN6,SKAP1
6.777e-03	-4.99	CYTH1 (cytohesin 1)	protein interactions	9267	49	2	19454	49	IPCEF1,PRKCD
6.812e-03	-4.99	negative regulation of hemostasis	biological process	GO:1900047	46	2	18204	49	APOE,PRKCD
6.903e-03	-4.98	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	16	18204	49	PIK3R5,BLNK,HIF1A,CD74,IL6R,SPI1,SKAP1,P2RY6,PRKCD,PLCG2,APOE,IRF5,STAT6,DENND1B,SBNO2,CSF1R
6.978e-03	-4.97	regulation of innate immune response	biological process	GO:0045088	449	5	18204	49	HCK,PTPN6,PLCG2,SPI1,APOE
7.000e-03	-4.96	Signaling events mediated by TCPTP	Pathway Interaction DB	tcptp_pathway	36	3	2226	25	CSF1R,GAB1,STAT6
7.049e-03	-4.95	TRIM15 (tripartite motif containing 15)	protein interactions	89870	50	2	19454	49	IRF5,GAB1
7.053e-03	-4.95	positive regulation of transport	biological process	GO:0051050	844	7	18204	49	HIF1A,P2RY6,PRKCD,P2RY2,APOE,DOCK2,PLCG2
7.092e-03	-4.95	ATG16L1 (autophagy related 16 like 1)	protein interactions	55054	1138	8	19454	49	DOCK2,ELMO1,GMIP,GIT2,ARHGAP15,PLCG2,AKAP13,TLN1
7.103e-03	-4.95	regulation of erythrocyte differentiation	biological process	GO:0045646	47	2	18204	49	SPI1,HIF1A
7.226e-03	-4.93	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	6	16828	45	CSF1R,HCK,NEK6,RHBDF2,PRKCD,ADCY7
7.241e-03	-4.93	PPP6R1 (protein phosphatase 6 regulatory subunit 1)	protein interactions	22870	157	3	19454	49	IRF5,CD74,P2RY6
7.246e-03	-4.93	leukocyte chemotaxis	biological process	GO:0030595	147	3	18204	49	IL6R,PREX1,VAV3
7.295e-03	-4.92	Signaling by the B Cell Receptor (BCR)	REACTOME pathways	R-HSA-983705	229	4	10285	35	PLCG2,GAB1,PTPN6,BLNK
7.325e-03	-4.92	CD247 (CD247 molecule)	protein interactions	919	51	2	19454	49	DOCK2,PTPN6
7.346e-03	-4.91	regulation of canonical NF-kappaB signal transduction	biological process	GO:0043122	287	4	18204	49	PLCG2,AKAP13,CD74,NEK6
7.382e-03	-4.91	regulation of reactive oxygen species metabolic process	biological process	GO:2000377	148	3	18204	49	PLCG2,PRKCD,HIF1A
7.399e-03	-4.91	icosanoid biosynthetic process	biological process	GO:0046456	48	2	18204	49	CD74,TBXAS1
7.399e-03	-4.91	regulation of inflammatory response to antigenic stimulus	biological process	GO:0002861	48	2	18204	49	HCK,RHBDF2
7.399e-03	-4.91	T cell differentiation involved in immune response	biological process	GO:0002292	48	2	18204	49	STAT6,IL6R
7.475e-03	-4.90	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	28	16828	45	WDFY4,GIT2,CSF1R,APOE,PRKCD,MYO1F,DOCK10,DENND1B,AKAP13,VAV3,HIF1A,SBNO2,DOCK1,TLN1,STAT6,ADCY7,DOCK2,ARHGAP27,PARVG,PIK3R5,PREX1,IPCEF1,GMIP,ELMO1,BLNK,ARHGAP15,SKAP1,GAB1
7.479e-03	-4.90	human chr2q36.2	chromosome location	human chr2q36.2	4	1	26134	49	DOCK10
7.496e-03	-4.89	COG6 (component of oligomeric golgi complex 6)	protein interactions	57511	159	3	19454	49	DOCK8,NEK6,P2RY6
7.538e-03	-4.89	Cops5 (COP9 signalosome subunit 5)	protein interactions	26754	3	1	19454	49	HIF1A
7.538e-03	-4.89	SIGLEC11 (sialic acid binding Ig like lectin 11)	protein interactions	114132	3	1	19454	49	PTPN6
7.538e-03	-4.89	EPYC (epiphycan)	protein interactions	1833	3	1	19454	49	PLCG2
7.538e-03	-4.89	FAM220A (family with sequence similarity 220 member A)	protein interactions	84792	3	1	19454	49	NEK6
7.538e-03	-4.89	ORF34 (ORF34;ORF36)	protein interactions	4961504	3	1	19454	49	HIF1A
7.538e-03	-4.89	Ahr (aryl-hydrocarbon receptor)	protein interactions	11622	3	1	19454	49	HIF1A
7.538e-03	-4.89	CX3CR1 (C-X3-C motif chemokine receptor 1)	protein interactions	1524	3	1	19454	49	HIF1A
7.538e-03	-4.89	SSX4B (SSX family member 4B)	protein interactions	548313	3	1	19454	49	HIF1A
7.557e-03	-4.89	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	40	16828	45	ADCY7,DOCK2,TBXAS1,PTPN6,PARVG,CD74,PIK3R5,PREX1,IPCEF1,ELMO1,GMIP,RGS14,BLNK,ARHGAP15,SKAP1,GAB1,ARHGAP33,P2RY2,RHBDF2,TBC1D8,WDFY4,CSF1R,GIT2,PLCG2,PRKCD,DOCK10,MYO1F,DENND1B,SPI1,AKAP13,VAV3,NEK6,IRF5,HIF1A,SBNO2,EHBP1L1,DOCK1,DOCK8,HCK,STAT6
7.605e-03	-4.88	CEBPE (CCAAT enhancer binding protein epsilon)	protein interactions	1053	52	2	19454	49	SPI1,STAT6
7.674e-03	-4.87	ciliary neurotrophic factor receptor complex	cellular component	GO:0070110	3	1	19108	49	IL6R
7.674e-03	-4.87	interleukin-6 receptor complex	cellular component	GO:0005896	3	1	19108	49	IL6R
7.700e-03	-4.87	platelet aggregation	biological process	GO:0070527	49	2	18204	49	TLN1,PTPN6
7.700e-03	-4.87	regulation of cell adhesion mediated by integrin	biological process	GO:0033628	49	2	18204	49	PTPN6,SKAP1
7.700e-03	-4.87	negative regulation of coagulation	biological process	GO:0050819	49	2	18204	49	APOE,PRKCD
7.700e-03	-4.87	visual learning	biological process	GO:0008542	49	2	18204	49	HIF1A,RGS14
7.765e-03	-4.86	signaling receptor complex adaptor activity	molecular function	GO:0030159	51	2	18094	47	BLNK,RGS14
7.773e-03	-4.86	interleukin-11 binding	molecular function	GO:0019970	3	1	18094	47	IL6R
7.773e-03	-4.86	diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	molecular function	GO:0004699	3	1	18094	47	PRKCD
7.773e-03	-4.86	interleukin-11 receptor activity	molecular function	GO:0004921	3	1	18094	47	IL6R
7.773e-03	-4.86	G protein-coupled ADP receptor activity	molecular function	GO:0001621	3	1	18094	47	P2RY6
7.773e-03	-4.86	A1 adenosine receptor binding	molecular function	GO:0031686	3	1	18094	47	P2RY2
7.773e-03	-4.86	12-hydroxyheptadecatrienoic acid synthase activity	molecular function	GO:0036134	3	1	18094	47	TBXAS1
7.798e-03	-4.85	negative regulation of protein phosphorylation	biological process	GO:0001933	292	4	18204	49	APOE,RGS14,PTPN6,PRKCD
7.799e-03	-4.85	negative regulation of secretion by cell	biological process	GO:1903531	151	3	18204	49	APOE,RHBDF2,SPI1
7.891e-03	-4.84	GNA12 (G protein subunit alpha 12)	protein interactions	2768	53	2	19454	49	AKAP13,PRKCD
7.891e-03	-4.84	VAV3 (vav guanine nucleotide exchange factor 3)	protein interactions	10451	53	2	19454	49	GAB1,BLNK
7.916e-03	-4.84	Parvin	interpro domains	IPR028433	3	1	18521	49	PARVG
7.916e-03	-4.84	CARMIL_PH	interpro domains	IPR041245	3	1	18521	49	CARMIL3
7.916e-03	-4.84	FYB1/2-like	interpro domains	IPR043443	3	1	18521	49	FYB1
7.916e-03	-4.84	PH_Vav	interpro domains	IPR037832	3	1	18521	49	VAV3
7.916e-03	-4.84	C2_Dock-C	interpro domains	IPR037808	3	1	18521	49	DOCK8
7.916e-03	-4.84	RGS10/12/14-like	interpro domains	IPR046995	3	1	18521	49	RGS14
7.916e-03	-4.84	ELMO_ARM	interpro domains	IPR024574	3	1	18521	49	ELMO1
7.916e-03	-4.84	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	49	HIF1A
7.916e-03	-4.84	C2_Dock-D	interpro domains	IPR037809	3	1	18521	49	DOCK10
7.916e-03	-4.84	FERM_f0	interpro domains	IPR032425	3	1	18521	49	TLN1
7.916e-03	-4.84	CARMIL_C	interpro domains	IPR031943	3	1	18521	49	CARMIL3
7.916e-03	-4.84	RII-bd_1	interpro domains	IPR018459	3	1	18521	49	AKAP13
7.916e-03	-4.84	DENND1A/B/C	interpro domains	IPR040032	3	1	18521	49	DENND1B
7.916e-03	-4.84	hSH3	interpro domains	IPR029294	3	1	18521	49	FYB1
7.941e-03	-4.84	regulation of actin polymerization or depolymerization	biological process	GO:0008064	152	3	18204	49	PREX1,HCK,PRKCD
7.941e-03	-4.84	blood vessel diameter maintenance	biological process	GO:0097746	152	3	18204	49	P2RY2,TBXAS1,APOE
7.941e-03	-4.84	regulation of tube diameter	biological process	GO:0035296	152	3	18204	49	P2RY2,TBXAS1,APOE
7.974e-03	-4.83	ATP5PO (ATP synthase peripheral stalk subunit OSCP)	protein interactions	539	314	4	19454	49	P2RY6,PREX1,APOE,DOCK8
8.007e-03	-4.83	modulation by host of viral process	biological process	GO:0044788	50	2	18204	49	CSF1R,APOE
8.011e-03	-4.83	GIT	smart domains	SM00555	2	1	9717	39	GIT2
8.040e-03	-4.82	regulation of programmed cell death	biological process	GO:0043067	1569	10	18204	49	CD74,HCK,HIF1A,PRKCD,CSF1R,GSDME,PLCG2,PTPN6,DOCK8,IRF5
8.054e-03	-4.82	positive regulation of antifungal innate immune response	biological process	GO:1905036	3	1	18204	49	SPI1
8.054e-03	-4.82	positive regulation of chemokine-mediated signaling pathway	biological process	GO:0070101	3	1	18204	49	HIF1A
8.054e-03	-4.82	leukocyte migration involved in immune response	biological process	GO:0002522	3	1	18204	49	HCK
8.054e-03	-4.82	adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process	biological process	GO:0086023	3	1	18204	49	AKAP13
8.054e-03	-4.82	myeloid dendritic cell activation involved in immune response	biological process	GO:0002277	3	1	18204	49	DOCK2
8.054e-03	-4.82	regulation of myeloid progenitor cell differentiation	biological process	GO:1905453	3	1	18204	49	SPI1
8.054e-03	-4.82	follicular B cell differentiation	biological process	GO:0002316	3	1	18204	49	PLCG2
8.054e-03	-4.82	membrane raft polarization	biological process	GO:0001766	3	1	18204	49	DOCK2
8.054e-03	-4.82	negative regulation of synaptic plasticity	biological process	GO:0031914	3	1	18204	49	RGS14
8.054e-03	-4.82	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	49	APOE
8.054e-03	-4.82	isotype switching to IgE isotypes	biological process	GO:0048289	3	1	18204	49	STAT6
8.054e-03	-4.82	neural fold elevation formation	biological process	GO:0021502	3	1	18204	49	HIF1A
8.054e-03	-4.82	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	49	APOE
8.054e-03	-4.82	positive regulation of phospholipid catabolic process	biological process	GO:0060697	3	1	18204	49	PRKCD
8.054e-03	-4.82	endothelial to hematopoietic transition	biological process	GO:0098508	3	1	18204	49	SPI1
8.054e-03	-4.82	regulation of macrophage migration inhibitory factor signaling pathway	biological process	GO:2000446	3	1	18204	49	CD74
8.054e-03	-4.82	termination of signal transduction	biological process	GO:0023021	3	1	18204	49	PRKCD
8.077e-03	-4.82	myeloid cell differentiation	biological process	GO:0030099	295	4	18204	49	CSF1R,SBNO2,SPI1,PTPN6
8.077e-03	-4.82	regulation of endocytosis	biological process	GO:0030100	295	4	18204	49	HCK,PLCG2,APOE,DOCK2
8.085e-03	-4.82	myeloid leukocyte differentiation	biological process	GO:0002573	153	3	18204	49	CSF1R,SBNO2,SPI1
8.085e-03	-4.82	regulation of tube size	biological process	GO:0035150	153	3	18204	49	P2RY2,TBXAS1,APOE
8.238e-03	-4.80	HIF-1	pfam domains	PF11413	3	1	17795	49	HIF1A
8.238e-03	-4.80	hSH3	pfam domains	PF14603	3	1	17795	49	FYB1
8.238e-03	-4.80	ELMO_ARM	pfam domains	PF11841	3	1	17795	49	ELMO1
8.238e-03	-4.80	Carm_PH	pfam domains	PF17888	3	1	17795	49	CARMIL3
8.238e-03	-4.80	FERM_f0	pfam domains	PF16511	3	1	17795	49	TLN1
8.238e-03	-4.80	CARMIL_C	pfam domains	PF16000	3	1	17795	49	CARMIL3
8.238e-03	-4.80	RII_binding_1	pfam domains	PF10522	3	1	17795	49	AKAP13
8.296e-03	-4.79	RASA1 (RAS p21 protein activator 1)	protein interactions	5921	165	3	19454	49	HCK,CSF1R,GAB1
8.320e-03	-4.79	regulation of granulocyte chemotaxis	biological process	GO:0071622	51	2	18204	49	CSF1R,CD74
8.328e-03	-4.79	upper_leg	COSMIC cancer mutations	upper_leg	880	7	16828	45	DOCK8,ARHGAP15,CSF1R,VAV3,NEK6,DOCK2,ELMO1
8.340e-03	-4.79	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	156	3	16828	45	HCK,BLNK,SPI1
8.362e-03	-4.78	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	45	16828	45	IPCEF1,ELMO1,GMIP,RGS14,BLNK,GAB1,ARHGAP33,ARHGAP15,SKAP1,P2RY2,ADCY7,DOCK2,TBXAS1,PTPN6,CD74,PARVG,ARHGAP27,PREX1,PIK3R5,AKAP13,SPI1,VAV3,IRF5,HIF1A,NEK6,DOCK1,SBNO2,EHBP1L1,TLN1,HCK,STAT6,DOCK8,RHBDF2,TBC1D8,CSF1R,GIT2,WDFY4,P2RY6,APOE,PLCG2,PRKCD,MYO1F,DOCK10,DENND1B,IL6R
8.362e-03	-4.78	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	5	10285	35	ADCY7,STAT6,TLN1,PRKCD,GAB1
8.377e-03	-4.78	regulation of actin filament length	biological process	GO:0030832	155	3	18204	49	PRKCD,HCK,PREX1
8.377e-03	-4.78	regulation of G protein-coupled receptor signaling pathway	biological process	GO:0008277	155	3	18204	49	HIF1A,RGS14,GIT2
8.388e-03	-4.78	HIF-1 signaling pathway	KEGG pathways	hsa04066	101	3	7161	30	HIF1A,PLCG2,IL6R
8.390e-03	-4.78	regulation of biological quality	biological process	GO:0065008	2936	15	18204	49	PLCG2,TLN1,APOE,HCK,CSF1R,ARHGAP33,ARHGAP15,PTPN6,RGS14,TBXAS1,HIF1A,P2RY2,PRKCD,PREX1,VAV3
8.477e-03	-4.77	DOCK1 (dedicator of cytokinesis 1)	protein interactions	1793	55	2	19454	49	IPCEF1,ELMO1
8.477e-03	-4.77	POLK (DNA polymerase kappa)	protein interactions	51426	55	2	19454	49	PARVG,STAT6
8.525e-03	-4.76	protein autophosphorylation	biological process	GO:0046777	156	3	18204	49	HCK,NEK6,CSF1R
8.550e-03	-4.76	Prot_kinase_dom	interpro domains	IPR000719	480	5	18521	49	PRKCD,NEK6,NRK,CSF1R,HCK
8.573e-03	-4.76	TP73 (tumor protein p73)	protein interactions	7161	167	3	19454	49	PRKCD,HCK,HIF1A
8.602e-03	-4.76	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	4	19454	49	HIF1A,PRKCD,TLN1,EHBP1L1
8.638e-03	-4.75	membrane invagination	biological process	GO:0010324	52	2	18204	49	DOCK1,ELMO1
8.675e-03	-4.75	positive regulation of endocytosis	biological process	GO:0045807	157	3	18204	49	PLCG2,APOE,DOCK2
8.713e-03	-4.74	KLK10 (kallikrein related peptidase 10)	protein interactions	5655	168	3	19454	49	MYO1F,PTPN6,APOE
8.776e-03	-4.74	PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma)	protein interactions	5294	56	2	19454	49	GAB1,PIK3R5
8.776e-03	-4.74	EML3 (EMAP like 3)	protein interactions	256364	56	2	19454	49	NEK6,SKAP1
8.826e-03	-4.73	regulation of blood vessel endothelial cell migration	biological process	GO:0043535	158	3	18204	49	APOE,GAB1,HIF1A
8.847e-03	-4.73	Focal adhesion	KEGG pathways	ko04510	198	4	7161	30	TLN1,VAV3,DOCK1,PARVG
8.847e-03	-4.73	Focal adhesion	KEGG pathways	hsa04510	198	4	7161	30	DOCK1,PARVG,TLN1,VAV3
8.962e-03	-4.71	regulation of platelet activation	biological process	GO:0010543	53	2	18204	49	PRKCD,APOE
9.081e-03	-4.70	PTPRC (protein tyrosine phosphatase receptor type C)	protein interactions	5788	57	2	19454	49	SKAP1,PTPN6
9.081e-03	-4.70	DOCK9 (dedicator of cytokinesis 9)	protein interactions	23348	57	2	19454	49	DOCK10,DOCK1
9.081e-03	-4.70	PRKCQ (protein kinase C theta)	protein interactions	5588	57	2	19454	49	PRKCD,FYB1
9.098e-03	-4.70	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	17	16828	45	WDFY4,DOCK2,DOCK10,DENND1B,PLCG2,CD74,BLNK,VAV3,HIF1A,ELMO1,AKAP13,HCK,STAT6,ARHGAP15,SKAP1,GAB1,DOCK1
9.213e-03	-4.69	human chr11q13.4	chromosome location	human chr11q13.4	77	2	26134	49	P2RY6,P2RY2
9.290e-03	-4.68	regulation of alcohol biosynthetic process	biological process	GO:1902930	54	2	18204	49	APOE,P2RY6
9.317e-03	-4.68	Signaling by GPCR	REACTOME pathways	R-HSA-372790	1299	10	10285	35	PRKCD,PIK3R5,VAV3,AKAP13,PREX1,TLN1,RGS14,P2RY6,P2RY2,ADCY7
9.390e-03	-4.67	KDM3A (lysine demethylase 3A)	protein interactions	55818	58	2	19454	49	STAT6,HIF1A
9.548e-03	-4.65	response to bacterium	biological process	GO:0009617	681	6	18204	49	PLCG2,IRF5,PRKCD,SBNO2,HCK,IL6R
9.575e-03	-4.65	negative regulation of cell adhesion	biological process	GO:0007162	310	4	18204	49	CD74,SPI1,PTPN6,PRKCD
9.586e-03	-4.65	GYPA (glycophorin A (MNS blood group))	protein interactions	2993	174	3	19454	49	DOCK1,NEK6,GSDME
9.586e-03	-4.65	SURF4 (surfeit 4)	protein interactions	6836	174	3	19454	49	P2RY2,P2RY6,DOCK1
9.625e-03	-4.64	neutrophil chemotaxis	biological process	GO:0030593	55	2	18204	49	PREX1,VAV3
9.625e-03	-4.64	CD4-positive, alpha-beta T cell differentiation	biological process	GO:0043367	55	2	18204	49	IL6R,STAT6
9.642e-03	-4.64	Proteoglycans in cancer	KEGG pathways	ko05205	203	4	7161	30	HIF1A,PLCG2,GAB1,PTPN6
9.642e-03	-4.64	Proteoglycans in cancer	KEGG pathways	hsa05205	203	4	7161	30	PLCG2,HIF1A,PTPN6,GAB1
9.703e-03	-4.64	C1_1	pfam domains	PF00130	54	2	17795	49	VAV3,PRKCD
9.713e-03	-4.63	-	gene3d domains	6.10.140.1000	3	1	14470	47	DENND1B
9.713e-03	-4.63	-	gene3d domains	6.10.250.810	3	1	14470	47	ELMO1
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	RGS14,ARHGAP33,DOCK10
9.767e-03	-4.63	positive regulation of leukocyte proliferation	biological process	GO:0070665	164	3	18204	49	CD74,CSF1R,VAV3
9.823e-03	-4.62	Th17 cell differentiation	KEGG pathways	hsa04659	107	3	7161	30	STAT6,HIF1A,IL6R
9.823e-03	-4.62	Th17 cell differentiation	KEGG pathways	ko04659	107	3	7161	30	HIF1A,STAT6,IL6R
9.871e-03	-4.62	cell-cell junction	cellular component	GO:0005911	513	5	19108	49	PRKCD,SKAP1,GAB1,PTPN6,TLN1
9.895e-03	-4.62	negative regulation of phosphorylation	biological process	GO:0042326	313	4	18204	49	APOE,PRKCD,PTPN6,RGS14
9.964e-03	-4.61	positive regulation of miRNA transcription	biological process	GO:1902895	56	2	18204	49	HIF1A,SPI1
1.000e-02	-4.60	positive regulation of response to biotic stimulus	biological process	GO:0002833	314	4	18204	49	HCK,PLCG2,SPI1,GSDME
1.004e-02	-4.60	Mapk1 (mitogen activated protein kinase 1)	protein interactions	116590	4	1	19454	49	HIF1A
1.004e-02	-4.60	Ocln (occludin)	protein interactions	18260	4	1	19454	49	PRKCD
1.004e-02	-4.60	CD34 (CD34 molecule)	protein interactions	947	4	1	19454	49	PRKCD
1.004e-02	-4.60	H1-10-AS1 (H1-10 antisense RNA 1)	protein interactions	339942	4	1	19454	49	PTPN6
1.004e-02	-4.60	TOP3B (DNA topoisomerase III beta)	protein interactions	8940	1465	9	19454	49	ARHGAP33,PREX1,IRF5,ADCY7,TLN1,AKAP13,EHBP1L1,RHBDF2,SBNO2
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	RGS14,ARHGAP33,DOCK10
1.007e-02	-4.60	Class I PI3K signaling events	Pathway Interaction DB	pi3kcipathway	41	3	2226	25	PLCG2,PREX1,HCK
1.018e-02	-4.59	STAT6-mediated induction of chemokines	REACTOME pathways	R-HSA-3249367	3	1	10285	35	STAT6
1.018e-02	-4.59	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	REACTOME pathways	R-HSA-1234162	3	1	10285	35	HIF1A
1.022e-02	-4.58	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	49	APOE
1.022e-02	-4.58	phosphatidylinositol 3-kinase complex, class IB	cellular component	GO:0005944	4	1	19108	49	PIK3R5
1.031e-02	-4.57	osteoclast differentiation	biological process	GO:0030316	57	2	18204	49	SBNO2,CSF1R
1.031e-02	-4.57	visual behavior	biological process	GO:0007632	57	2	18204	49	HIF1A,RGS14
1.035e-02	-4.57	FBXL12 (F-box and leucine rich repeat protein 12)	protein interactions	54850	61	2	19454	49	APOE,DOCK8
1.035e-02	-4.57	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	47	APOE
1.035e-02	-4.57	ciliary neurotrophic factor receptor activity	molecular function	GO:0004897	4	1	18094	47	IL6R
1.037e-02	-4.57	seminoma	COSMIC cancer mutations	seminoma	700	6	16828	45	ADCY7,PRKCD,RHBDF2,NEK6,CSF1R,HCK
1.044e-02	-4.56	Host Interactions of HIV factors	REACTOME pathways	R-HSA-162909	134	3	10285	35	DOCK2,HCK,ELMO1
1.054e-02	-4.55	Gab1-4-like	interpro domains	IPR046355	4	1	18521	49	GAB1
1.054e-02	-4.55	Prot_kin_PKC_delta	interpro domains	IPR014376	4	1	18521	49	PRKCD
1.054e-02	-4.55	ApoA_E	interpro domains	IPR000074	4	1	18521	49	APOE
1.054e-02	-4.55	ILWEQ_dom	interpro domains	IPR002558	4	1	18521	49	TLN1
1.054e-02	-4.55	I/LWEQ_dom_sf	interpro domains	IPR035964	4	1	18521	49	TLN1
1.054e-02	-4.55	NT-C2	interpro domains	IPR019448	4	1	18521	49	EHBP1L1
1.059e-02	-4.55	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	5	16828	45	TBC1D8,PRKCD,NEK6,CSF1R,HCK
1.072e-02	-4.54	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	49	APOE
1.072e-02	-4.54	positive regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032962	4	1	18204	49	P2RY6
1.072e-02	-4.54	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	49	APOE
1.072e-02	-4.54	positive regulation of establishment of T cell polarity	biological process	GO:1903905	4	1	18204	49	DOCK8
1.072e-02	-4.54	positive regulation of isotype switching to IgE isotypes	biological process	GO:0048295	4	1	18204	49	STAT6
1.072e-02	-4.54	negative regulation of mast cell activation involved in immune response	biological process	GO:0033007	4	1	18204	49	PTPN6
1.072e-02	-4.54	B-1 B cell homeostasis	biological process	GO:0001922	4	1	18204	49	HIF1A
1.072e-02	-4.54	respiratory burst after phagocytosis	biological process	GO:0045728	4	1	18204	49	HCK
1.072e-02	-4.54	macrophage colony-stimulating factor signaling pathway	biological process	GO:0038145	4	1	18204	49	CSF1R
1.072e-02	-4.54	response to caloric restriction	biological process	GO:0061771	4	1	18204	49	APOE
1.072e-02	-4.54	T-helper 1 cell lineage commitment	biological process	GO:0002296	4	1	18204	49	STAT6
1.072e-02	-4.54	positive regulation of endodeoxyribonuclease activity	biological process	GO:0032079	4	1	18204	49	PRKCD
1.072e-02	-4.54	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	49	APOE
1.072e-02	-4.54	regulation of inositol trisphosphate biosynthetic process	biological process	GO:0032960	4	1	18204	49	P2RY6
1.072e-02	-4.54	regulation of mature B cell apoptotic process	biological process	GO:0002905	4	1	18204	49	CD74
1.072e-02	-4.54	negative regulation of mature B cell apoptotic process	biological process	GO:0002906	4	1	18204	49	CD74
1.072e-02	-4.54	positive regulation of microglial cell mediated cytotoxicity	biological process	GO:1904151	4	1	18204	49	SPI1
1.072e-02	-4.54	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031587	4	1	18204	49	P2RY6
1.072e-02	-4.54	epithelial cell differentiation involved in mammary gland alveolus development	biological process	GO:0061030	4	1	18204	49	HIF1A
1.076e-02	-4.53	negative regulation of protein kinase activity	biological process	GO:0006469	170	3	18204	49	APOE,PRKCD,RGS14
1.089e-02	-4.52	INSR (insulin receptor)	protein interactions	3643	344	4	19454	49	PTPN6,GAB1,VAV3,PRKCD
1.097e-02	-4.51	I_LWEQ	pfam domains	PF01608	4	1	17795	49	TLN1
1.097e-02	-4.51	NT-C2	pfam domains	PF10358	4	1	17795	49	EHBP1L1
1.097e-02	-4.51	Apolipoprotein	pfam domains	PF01442	4	1	17795	49	APOE
1.101e-02	-4.51	IFNAR1 (interferon alpha and beta receptor subunit 1)	protein interactions	3454	63	2	19454	49	PTPN6,STAT6
1.103e-02	-4.51	leading edge membrane	cellular component	GO:0031256	180	3	19108	49	TLN1,PLCG2,DOCK8
1.103e-02	-4.51	Signaling Pathways in Glioblastoma	WikiPathways	WP2261	83	3	5310	30	PRKCD,PLCG2,GAB1
1.104e-02	-4.51	specific granule lumen	cellular component	GO:0035580	62	2	19108	49	DOCK2,PTPN6
1.105e-02	-4.51	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	2	10285	35	ADCY7,PRKCD
1.108e-02	-4.50	protein phosphorylation	biological process	GO:0006468	503	5	18204	49	CSF1R,NEK6,HCK,PRKCD,PTPN6
1.113e-02	-4.50	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	5	12186	44	HCK,NEK6,NRK,CSF1R,PRKCD
1.126e-02	-4.49	response to inorganic substance	biological process	GO:0010035	505	5	18204	49	ADCY7,PLCG2,PRKCD,HIF1A,STAT6
1.126e-02	-4.49	cellular response to organonitrogen compound	biological process	GO:0071417	505	5	18204	49	GAB1,P2RY6,PRKCD,P2RY2,STAT6
1.128e-02	-4.48	regulation of smooth muscle cell proliferation	biological process	GO:0048660	173	3	18204	49	APOE,P2RY6,IL6R
1.131e-02	-4.48	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	4	5310	30	ADCY7,PLCG2,PRKCD,RGS14
1.134e-02	-4.48	LRCH2 (leucine rich repeats and calponin homology domain containing 2)	protein interactions	57631	64	2	19454	49	DOCK8,DOCK2
1.134e-02	-4.48	DGKE (diacylglycerol kinase epsilon)	protein interactions	8526	64	2	19454	49	P2RY6,CD74
1.137e-02	-4.48	positive regulation of cytokine-mediated signaling pathway	biological process	GO:0001961	60	2	18204	49	HIF1A,CD74
1.148e-02	-4.47	regulation of lipid metabolic process	biological process	GO:0019216	327	4	18204	49	PRKCD,PLCG2,CD74,APOE
1.149e-02	-4.47	IL6-mediated signaling events	Pathway Interaction DB	il6_7pathway	43	3	2226	25	IL6R,HCK,PRKCD
1.151e-02	-4.46	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	2	10285	35	ADCY7,PRKCD
1.151e-02	-4.46	G alpha (z) signalling events	REACTOME pathways	R-HSA-418597	48	2	10285	35	ADCY7,PRKCD
1.153e-02	-4.46	circulatory system process	biological process	GO:0003013	508	5	18204	49	TBXAS1,APOE,P2RY2,TBC1D8,AKAP13
1.155e-02	-4.46	EPHA2 (EPH receptor A2)	protein interactions	1969	350	4	19454	49	GAB1,CSF1R,HIF1A,HCK
1.160e-02	-4.46	positive regulation of cell-cell adhesion	biological process	GO:0022409	328	4	18204	49	DOCK8,CD74,SKAP1,PTPN6
1.160e-02	-4.46	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	9	16828	45	WDFY4,VAV3,ELMO1,DOCK2,DOCK10,ARHGAP15,SKAP1,CD74,DOCK1
1.168e-02	-4.45	ESRRA (estrogen related receptor alpha)	protein interactions	2101	65	2	19454	49	HIF1A,PRKCD
1.174e-02	-4.44	bone mineralization	biological process	GO:0030282	61	2	18204	49	SBNO2,HIF1A
1.189e-02	-4.43	BCAR1 (BCAR1 scaffold protein, Cas family member)	protein interactions	9564	547	5	19454	49	FYB1,DOCK2,HCK,DOCK1,TLN1
1.196e-02	-4.43	regulation of small molecule metabolic process	biological process	GO:0062012	331	4	18204	49	P2RY6,HIF1A,CD74,APOE
1.209e-02	-4.42	Kinase-like_dom_sf	interpro domains	IPR011009	523	5	18521	49	PRKCD,NEK6,CSF1R,NRK,HCK
1.211e-02	-4.41	regulation of substrate adhesion-dependent cell spreading	biological process	GO:1900024	62	2	18204	49	PREX1,DOCK1
1.211e-02	-4.41	regulation of B cell mediated immunity	biological process	GO:0002712	62	2	18204	49	PTPN6,STAT6
1.211e-02	-4.41	regulation of immunoglobulin mediated immune response	biological process	GO:0002889	62	2	18204	49	PTPN6,STAT6
1.211e-02	-4.41	macrophage activation	biological process	GO:0042116	62	2	18204	49	PLCG2,SBNO2
1.227e-02	-4.40	regulation of vesicle-mediated transport	biological process	GO:0060627	516	5	18204	49	PLCG2,SPI1,HCK,DOCK2,APOE
1.237e-02	-4.39	regulation of response to wounding	biological process	GO:1903034	179	3	18204	49	APOE,PRKCD,PTPN6
1.246e-02	-4.39	peptidyl-amino acid modification	biological process	GO:0018193	518	5	18204	49	NEK6,CSF1R,PRKCD,PTPN6,HCK
1.246e-02	-4.39	KHDRBS1 (KH RNA binding domain containing, signal transduction associated 1)	protein interactions	10657	358	4	19454	49	PLCG2,HCK,PTPN6,DOCK2
1.247e-02	-4.38	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	COSMIC cancer mutations	central_nervous_system-brainstem-primitive_neuroectodermal_tumour-medulloblastoma-WNT_subtype	181	3	16828	45	ELMO1,VAV3,WDFY4
1.250e-02	-4.38	UBE3C (ubiquitin protein ligase E3C)	protein interactions	9690	192	3	19454	49	HIF1A,P2RY6,CD74
1.253e-02	-4.38	NBR2 (neighbor of BRCA1 lncRNA 2)	protein interactions	10230	5	1	19454	49	GMIP
1.253e-02	-4.38	VHLL (VHL like)	protein interactions	391104	5	1	19454	49	HIF1A
1.253e-02	-4.38	NBPF6 (NBPF member 6)	protein interactions	653149	5	1	19454	49	PARVG
1.253e-02	-4.38	LINC01139 (long intergenic non-protein coding RNA 1139)	protein interactions	339535	5	1	19454	49	HIF1A
1.253e-02	-4.38	Vhl (von Hippel-Lindau tumor suppressor)	protein interactions	24874	5	1	19454	49	HIF1A
1.253e-02	-4.38	SNHG11 (small nucleolar RNA host gene 11)	protein interactions	128439	5	1	19454	49	HIF1A
1.266e-02	-4.37	WNT_subtype	COSMIC cancer mutations	WNT_subtype	182	3	16828	45	VAV3,WDFY4,ELMO1
1.270e-02	-4.37	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	16	16828	45	TLN1,HCK,P2RY2,GAB1,DOCK1,ARHGAP15,SKAP1,SBNO2,VAV3,AKAP13,DENND1B,PTPN6,PLCG2,CSF1R,WDFY4,DOCK2
1.274e-02	-4.36	negative regulation of kinase activity	biological process	GO:0033673	181	3	18204	49	APOE,RGS14,PRKCD
1.276e-02	-4.36	alpha-beta T cell receptor complex	cellular component	GO:0042105	5	1	19108	49	PTPN6
1.277e-02	-4.36	negative regulation of programmed cell death	biological process	GO:0043069	946	7	18204	49	PRKCD,HCK,HIF1A,CD74,CSF1R,PLCG2,DOCK8
1.280e-02	-4.36	phosphatase binding	molecular function	GO:0019902	188	3	18094	47	STAT6,SKAP1,CSF1R
1.281e-02	-4.36	multivesicular body	cellular component	GO:0005771	67	2	19108	49	APOE,CD74
1.281e-02	-4.36	testis	COSMIC cancer mutations	testis	733	6	16828	45	PRKCD,HCK,RHBDF2,ADCY7,NEK6,CSF1R
1.285e-02	-4.35	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	13	16828	45	DOCK10,PREX1,WDFY4,CSF1R,DOCK2,SKAP1,ARHGAP15,DOCK1,GAB1,BLNK,VAV3,ELMO1,AKAP13
1.285e-02	-4.35	SORT1 (sortilin 1)	protein interactions	6272	194	3	19454	49	TBC1D8,P2RY6,TLN1
1.287e-02	-4.35	regulation of B cell proliferation	biological process	GO:0030888	64	2	18204	49	VAV3,CD74
1.287e-02	-4.35	cellular senescence	biological process	GO:0090398	64	2	18204	49	PRKCD,SPI1
1.287e-02	-4.35	regulation of interleukin-12 production	biological process	GO:0032655	64	2	18204	49	IRF5,PLCG2
1.292e-02	-4.35	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	2	10285	35	GAB1,PRKCD
1.293e-02	-4.35	Talin, central domain	gene3d domains	1.20.1420.10	4	1	14470	47	TLN1
1.293e-02	-4.35	plasma membrane signaling receptor complex	cellular component	GO:0098802	191	3	19108	49	SKAP1,PTPN6,IL6R
1.293e-02	-4.35	regulation of cytokine-mediated signaling pathway	biological process	GO:0001959	182	3	18204	49	HIF1A,CD74,PTPN6
1.294e-02	-4.35	PSMD3 (proteasome 26S subunit, non-ATPase 3)	protein interactions	5709	362	4	19454	49	PTPN6,P2RY6,PLCG2,CD74
1.299e-02	-4.34	Interleukin-3, 5 and GM-CSF signaling	REACTOME pathways	R-HSA-512988	271	4	10285	35	BLNK,HCK,PTPN6,TLN1
1.303e-02	-4.34	CD2AP (CD2 associated protein)	protein interactions	23607	195	3	19454	49	HCK,BLNK,RHBDF2
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	SKAP1,ARHGAP33
1.304e-02	-4.34	femur	COSMIC cancer mutations	femur	1197	8	16828	45	WDFY4,BLNK,AKAP13,RHBDF2,DOCK10,PREX1,P2RY2,ARHGAP15
1.306e-02	-4.34	phosphorylation	biological process	GO:0016310	729	6	18204	49	NRK,HCK,PRKCD,PTPN6,CSF1R,NEK6
1.307e-02	-4.34	regulation of response to stress	biological process	GO:0080134	1431	9	18204	49	SPI1,SBNO2,PRKCD,HCK,CD74,RHBDF2,APOE,PTPN6,PLCG2
1.310e-02	-4.34	EVL (Enah/Vasp-like)	protein interactions	51466	69	2	19454	49	FYB1,HCK
1.310e-02	-4.34	anatomical structure morphogenesis	biological process	GO:0009653	2225	12	18204	49	VAV3,HIF1A,SPI1,DOCK1,DOCK10,DOCK2,PTPN6,GAB1,CSF1R,STAT6,SBNO2,APOE
1.310e-02	-4.33	Neurotrophin signaling pathway	KEGG pathways	ko04722	119	3	7161	30	GAB1,PLCG2,PRKCD
1.310e-02	-4.33	Neurotrophin signaling pathway	KEGG pathways	hsa04722	119	3	7161	30	PLCG2,PRKCD,GAB1
1.316e-02	-4.33	Gasdermin_PUB	interpro domains	IPR041263	5	1	18521	49	GSDME
1.316e-02	-4.33	Hematopoietin_rcpt_L_F3_CS	interpro domains	IPR003530	5	1	18521	49	IL6R
1.321e-02	-4.33	BLK (BLK proto-oncogene, Src family tyrosine kinase)	protein interactions	640	196	3	19454	49	HCK,GAB1,PLCG2
1.325e-02	-4.32	T cell differentiation in thymus	biological process	GO:0033077	65	2	18204	49	DOCK2,CD74
1.339e-02	-4.31	hypoxia-inducible factor-1alpha signaling pathway	biological process	GO:0097411	5	1	18204	49	HIF1A
1.339e-02	-4.31	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	49	APOE
1.339e-02	-4.31	regulation of mast cell activation involved in immune response	biological process	GO:0033006	5	1	18204	49	PTPN6
1.339e-02	-4.31	connective tissue replacement involved in inflammatory response wound healing	biological process	GO:0002248	5	1	18204	49	HIF1A
1.339e-02	-4.31	negative regulation of filopodium assembly	biological process	GO:0051490	5	1	18204	49	PRKCD
1.339e-02	-4.31	regulation of microglial cell mediated cytotoxicity	biological process	GO:1904149	5	1	18204	49	SPI1
1.339e-02	-4.31	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	49	APOE
1.339e-02	-4.31	epididymis development	biological process	GO:1905867	5	1	18204	49	PTPN6
1.339e-02	-4.31	regulation of glucosylceramide catabolic process	biological process	GO:2000752	5	1	18204	49	PRKCD
1.339e-02	-4.31	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	49	APOE
1.339e-02	-4.31	negative regulation of adipose tissue development	biological process	GO:1904178	5	1	18204	49	SPI1
1.339e-02	-4.31	positive regulation of deoxyribonuclease activity	biological process	GO:0032077	5	1	18204	49	PRKCD
1.339e-02	-4.31	regulation of antifungal innate immune response	biological process	GO:1905034	5	1	18204	49	SPI1
1.339e-02	-4.31	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	49	APOE
1.339e-02	-4.31	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	49	APOE
1.339e-02	-4.31	ciliary neurotrophic factor-mediated signaling pathway	biological process	GO:0070120	5	1	18204	49	IL6R
1.339e-02	-4.31	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	biological process	GO:0031585	5	1	18204	49	P2RY6
1.346e-02	-4.31	ITGB3 (integrin subunit beta 3)	protein interactions	3690	70	2	19454	49	TLN1,P2RY2
1.356e-02	-4.30	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	5	16828	45	VAV3,PREX1,WDFY4,DOCK2,ARHGAP15
1.361e-02	-4.30	parathyroid-adenoma	COSMIC cancer mutations	parathyroid-adenoma	187	3	16828	45	PLCG2,TBC1D8,PRKCD
1.364e-02	-4.29	positive regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042531	66	2	18204	49	CSF1R,IL6R
1.364e-02	-4.29	neutrophil migration	biological process	GO:1990266	66	2	18204	49	PREX1,VAV3
1.364e-02	-4.29	homotypic cell-cell adhesion	biological process	GO:0034109	66	2	18204	49	PTPN6,TLN1
1.369e-02	-4.29	Gasdermin_C	pfam domains	PF17708	5	1	17795	49	GSDME
1.382e-02	-4.28	Integrins in angiogenesis	Pathway Interaction DB	avb3_integrin_pathway	46	3	2226	25	TLN1,CSF1R,VAV3
1.390e-02	-4.28	regulation of lymphocyte mediated immunity	biological process	GO:0002706	187	3	18204	49	PTPN6,DENND1B,STAT6
1.394e-02	-4.27	FANCI (FA complementation group I)	protein interactions	55215	200	3	19454	49	NEK6,P2RY6,HIF1A
1.404e-02	-4.27	positive regulation of response to cytokine stimulus	biological process	GO:0060760	67	2	18204	49	CD74,HIF1A
1.404e-02	-4.27	positive regulation of miRNA metabolic process	biological process	GO:2000630	67	2	18204	49	SPI1,HIF1A
1.405e-02	-4.27	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	6	16828	45	PLCG2,ELMO1,DOCK1,CD74,HCK,STAT6
1.405e-02	-4.27	anatomical structure formation involved in morphogenesis	biological process	GO:0048646	964	7	18204	49	GAB1,VAV3,DOCK2,HIF1A,SBNO2,DOCK1,PTPN6
1.406e-02	-4.26	innate immune response	biological process	GO:0045087	741	6	18204	49	IRF5,CSF1R,PTPN6,PLCG2,CD74,HCK
1.420e-02	-4.25	FANCL (FA complementation group L)	protein interactions	55120	72	2	19454	49	IL6R,DOCK8
1.420e-02	-4.25	ITGB2 (integrin subunit beta 2)	protein interactions	3689	72	2	19454	49	PRKCD,TLN1
1.430e-02	-4.25	regulation of lipid biosynthetic process	biological process	GO:0046890	189	3	18204	49	APOE,CD74,PRKCD
1.430e-02	-4.25	regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001242	189	3	18204	49	CD74,HIF1A,GSDME
1.437e-02	-4.24	I_LWEQ	prosite domains	PS50945	4	1	12186	44	TLN1
1.437e-02	-4.24	C2_NT	prosite domains	PS51840	4	1	12186	44	EHBP1L1
1.444e-02	-4.24	cellular response to hydrogen peroxide	biological process	GO:0070301	68	2	18204	49	STAT6,PRKCD
1.444e-02	-4.24	cell-cell recognition	biological process	GO:0009988	68	2	18204	49	DOCK8,DOCK2
1.444e-02	-4.24	negative regulation of leukocyte mediated immunity	biological process	GO:0002704	68	2	18204	49	SPI1,PTPN6
1.444e-02	-4.24	CD4-positive, alpha-beta T cell activation	biological process	GO:0035710	68	2	18204	49	STAT6,IL6R
1.458e-02	-4.23	PANK4 (pantothenate kinase 4 (inactive))	protein interactions	55229	73	2	19454	49	GMIP,PTPN6
1.466e-02	-4.22	CH	pfam domains	PF00307	67	2	17795	49	EHBP1L1,PARVG
1.470e-02	-4.22	INPPL1 (inositol polyphosphate phosphatase like 1)	protein interactions	3636	204	3	19454	49	CSF1R,GAB1,STAT6
1.477e-02	-4.22	Immunoglobulin	interpro domains	IPR013151	70	2	18521	49	IL6R,CSF1R
1.485e-02	-4.21	regulation of blood coagulation	biological process	GO:0030193	69	2	18204	49	PRKCD,APOE
1.496e-02	-4.20	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	2	19454	49	GAB1,PLCG2
1.496e-02	-4.20	NGEF (neuronal guanine nucleotide exchange factor)	protein interactions	25791	74	2	19454	49	HCK,PRKCD
1.498e-02	-4.20	response to molecule of bacterial origin	biological process	GO:0002237	354	4	18204	49	IRF5,PLCG2,SBNO2,HCK
1.502e-02	-4.20	CD300LF (CD300 molecule like family member f)	protein interactions	146722	6	1	19454	49	PTPN6
1.502e-02	-4.20	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	49	APOE
1.502e-02	-4.20	EBNA-2 (nuclear antigen EBNA-2)	protein interactions	3783761	6	1	19454	49	SPI1
1.502e-02	-4.20	SETD9 (SET domain containing 9)	protein interactions	133383	6	1	19454	49	PLCG2
1.502e-02	-4.20	NBPF22P (NBPF member 22, pseudogene)	protein interactions	285622	6	1	19454	49	PARVG
1.502e-02	-4.20	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	49	APOE
1.502e-02	-4.20	echA1 (enoyl-CoA hydratase EchA1)	protein interactions	886723	6	1	19454	49	PTPN6
1.509e-02	-4.19	superpathway of inositol phosphate compounds	BIOCYC pathways	HUMAN_PWY-6371	66	2	902	3	PLCG2,PIK3R5
1.526e-02	-4.18	positive regulation of reactive oxygen species metabolic process	biological process	GO:2000379	70	2	18204	49	PLCG2,PRKCD
1.529e-02	-4.18	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	49	APOE
1.533e-02	-4.18	regulation of response to cytokine stimulus	biological process	GO:0060759	194	3	18204	49	PTPN6,CD74,HIF1A
1.533e-02	-4.18	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002822	194	3	18204	49	PTPN6,DENND1B,STAT6
1.537e-02	-4.18	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	6	16828	45	GMIP,CSF1R,NEK6,WDFY4,PRKCD,HCK
1.537e-02	-4.18	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	6	16828	45	GMIP,PRKCD,WDFY4,HCK,CSF1R,NEK6
1.547e-02	-4.17	PAK2 (p21 (RAC1) activated kinase 2)	protein interactions	5062	208	3	19454	49	DOCK2,HCK,GIT2
1.548e-02	-4.17	Signaling of Hepatocyte Growth Factor Receptor	WikiPathways	WP313	34	2	5310	30	GAB1,DOCK1
1.549e-02	-4.17	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	47	APOE
1.549e-02	-4.17	NFAT protein binding	molecular function	GO:0051525	6	1	18094	47	SPI1
1.549e-02	-4.17	LIM domain binding	molecular function	GO:0030274	6	1	18094	47	TLN1
1.567e-02	-4.16	regulation of hemostasis	biological process	GO:1900046	71	2	18204	49	APOE,PRKCD
1.567e-02	-4.16	lymphocyte homeostasis	biological process	GO:0002260	71	2	18204	49	HIF1A,DOCK10
1.573e-02	-4.15	RUNX2 (RUNX family transcription factor 2)	protein interactions	860	76	2	19454	49	HIF1A,PRKCD
1.577e-02	-4.15	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	49	ADCY7
1.577e-02	-4.15	ELMO_dom	interpro domains	IPR006816	6	1	18521	49	ELMO1
1.577e-02	-4.15	Gasdermin_pore	interpro domains	IPR040460	6	1	18521	49	GSDME
1.577e-02	-4.15	CAMSAP-like_CH_dom	interpro domains	IPR022613	6	1	18521	49	VAV3
1.587e-02	-4.14	clathrin-coated endocytic vesicle membrane	cellular component	GO:0030669	75	2	19108	49	CD74,APOE
1.588e-02	-4.14	G Protein Signaling Pathways	WikiPathways	WP35	95	3	5310	30	ADCY7,AKAP13,PRKCD
1.592e-02	-4.14	cerebellum	COSMIC cancer mutations	cerebellum	769	6	16828	45	SKAP1,ELMO1,DOCK2,WDFY4,STAT6,DOCK10
1.592e-02	-4.14	ig	pfam domains	PF00047	70	2	17795	49	IL6R,CSF1R
1.595e-02	-4.14	positive regulation of protein modification process	biological process	GO:0031401	762	6	18204	49	CSF1R,PIK3R5,CD74,IL6R,PLCG2,PRKCD
1.595e-02	-4.14	cell projection	cellular component	GO:0042995	2398	12	19108	49	RGS14,APOE,DOCK8,PREX1,TLN1,PLCG2,HIF1A,ARHGAP33,DOCK10,HCK,MYO1F,CARMIL3
1.596e-02	-4.14	ILWEQ	smart domains	SM00307	4	1	9717	39	TLN1
1.597e-02	-4.14	protein localization to plasma membrane	biological process	GO:0072659	197	3	18204	49	SKAP1,RHBDF2,FYB1
1.604e-02	-4.13	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	49	APOE
1.604e-02	-4.13	regulation of phospholipid translocation	biological process	GO:0061091	6	1	18204	49	PRKCD
1.604e-02	-4.13	negative regulation of protein localization to chromatin	biological process	GO:0120186	6	1	18204	49	SPI1
1.604e-02	-4.13	membrane raft distribution	biological process	GO:0031580	6	1	18204	49	DOCK2
1.604e-02	-4.13	positive regulation of nuclease activity	biological process	GO:0032075	6	1	18204	49	PRKCD
1.604e-02	-4.13	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	49	APOE
1.604e-02	-4.13	inositol trisphosphate metabolic process	biological process	GO:0032957	6	1	18204	49	PLCG2
1.604e-02	-4.13	osteoclast fusion	biological process	GO:0072675	6	1	18204	49	SBNO2
1.604e-02	-4.13	oncogene-induced cell senescence	biological process	GO:0090402	6	1	18204	49	SPI1
1.604e-02	-4.13	positive regulation of prostaglandin biosynthetic process	biological process	GO:0031394	6	1	18204	49	CD74
1.604e-02	-4.13	regulation of defense response to fungus	biological process	GO:1900150	6	1	18204	49	SPI1
1.604e-02	-4.13	regulation of lipid transporter activity	biological process	GO:0110112	6	1	18204	49	PRKCD
1.604e-02	-4.13	interleukin-11-mediated signaling pathway	biological process	GO:0038154	6	1	18204	49	IL6R
1.604e-02	-4.13	positive regulation of I-kappaB phosphorylation	biological process	GO:1903721	6	1	18204	49	PLCG2
1.604e-02	-4.13	elastin metabolic process	biological process	GO:0051541	6	1	18204	49	HIF1A
1.604e-02	-4.13	positive regulation of mucus secretion	biological process	GO:0070257	6	1	18204	49	P2RY2
1.604e-02	-4.13	positive regulation of macrophage proliferation	biological process	GO:0120041	6	1	18204	49	CSF1R
1.604e-02	-4.13	hemoglobin biosynthetic process	biological process	GO:0042541	6	1	18204	49	HIF1A
1.604e-02	-4.13	regulation of establishment of T cell polarity	biological process	GO:1903903	6	1	18204	49	DOCK8
1.604e-02	-4.13	intestinal epithelial cell maturation	biological process	GO:0060574	6	1	18204	49	HIF1A
1.604e-02	-4.13	positive regulation of cell-cell adhesion mediated by integrin	biological process	GO:0033634	6	1	18204	49	SKAP1
1.607e-02	-4.13	HEATR1 (HEAT repeat containing 1)	protein interactions	55127	211	3	19454	49	P2RY2,P2RY6,HIF1A
1.613e-02	-4.13	DYM (dymeclin)	protein interactions	54808	77	2	19454	49	P2RY2,P2RY6
1.614e-02	-4.13	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	47	APOE
1.636e-02	-4.11	Alpha 6 Beta 4 signaling pathway	WikiPathways	WP244	35	2	5310	30	GAB1,PRKCD
1.640e-02	-4.11	positive regulation of protein-containing complex assembly	biological process	GO:0031334	199	3	18204	49	PLCG2,SKAP1,HCK
1.640e-02	-4.11	head_neck	COSMIC cancer mutations	head_neck	15361	45	16828	45	IPCEF1,ELMO1,RGS14,BLNK,SKAP1,GAB1,ARHGAP33,PTPN6,PREX1,SPI1,VAV3,DOCK8,TLN1,PLCG2,P2RY6,IL6R,MYO1F,DENND1B,GMIP,ARHGAP15,P2RY2,ADCY7,DOCK2,TBXAS1,ARHGAP27,PARVG,CD74,PIK3R5,AKAP13,IRF5,HIF1A,NEK6,EHBP1L1,SBNO2,DOCK1,HCK,STAT6,RHBDF2,TBC1D8,WDFY4,GIT2,CSF1R,APOE,PRKCD,DOCK10
1.641e-02	-4.11	ELMO_CED12	pfam domains	PF04727	6	1	17795	49	ELMO1
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY7
1.641e-02	-4.11	Gasdermin	pfam domains	PF04598	6	1	17795	49	GSDME
1.641e-02	-4.11	CAMSAP_CH	pfam domains	PF11971	6	1	17795	49	VAV3
1.641e-02	-4.11	RBD	pfam domains	PF02196	6	1	17795	49	RGS14
1.650e-02	-4.10	protein kinase activity	molecular function	GO:0004672	577	5	18094	47	NEK6,PRKCD,CSF1R,HCK,NRK
1.652e-02	-4.10	negative regulation of wound healing	biological process	GO:0061045	73	2	18204	49	APOE,PRKCD
1.652e-02	-4.10	positive regulation of phagocytosis	biological process	GO:0050766	73	2	18204	49	PLCG2,DOCK2
1.668e-02	-4.09	GNAI3 (G protein subunit alpha i3)	protein interactions	2773	214	3	19454	49	RHBDF2,RGS14,GAB1
1.668e-02	-4.09	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	49	BLNK,GAB1,GIT2
1.689e-02	-4.08	XPO5 (exportin 5)	protein interactions	57510	215	3	19454	49	NEK6,P2RY6,HIF1A
1.690e-02	-4.08	MET activates PTPN11	REACTOME pathways	R-HSA-8865999	5	1	10285	35	GAB1
1.690e-02	-4.08	PTK6 Expression	REACTOME pathways	R-HSA-8849473	5	1	10285	35	HIF1A
1.693e-02	-4.08	IRF4 (interferon regulatory factor 4)	protein interactions	3662	79	2	19454	49	STAT6,SPI1
1.695e-02	-4.08	regulation of coagulation	biological process	GO:0050818	74	2	18204	49	PRKCD,APOE
1.706e-02	-4.07	regulation of protein polymerization	biological process	GO:0032271	202	3	18204	49	HCK,PRKCD,PREX1
1.710e-02	-4.07	HACD3 (3-hydroxyacyl-CoA dehydratase 3)	protein interactions	51495	216	3	19454	49	ARHGAP15,NEK6,P2RY6
1.714e-02	-4.07	positive regulation of macromolecule biosynthetic process	biological process	GO:0010557	2592	13	18204	49	PLCG2,APOE,BLNK,IRF5,HIF1A,STAT6,DENND1B,CD74,IL6R,SPI1,SKAP1,SBNO2,CSF1R
1.722e-02	-4.06	negative regulation of response to stimulus	biological process	GO:0048585	1760	10	18204	49	APOE,RHBDF2,PTPN6,RGS14,CD74,HIF1A,HCK,STAT6,PRKCD,SPI1
1.729e-02	-4.06	Natural killer cell mediated cytotoxicity	KEGG pathways	ko04650	132	3	7161	30	PTPN6,VAV3,PLCG2
1.729e-02	-4.06	Natural killer cell mediated cytotoxicity	KEGG pathways	hsa04650	132	3	7161	30	VAV3,PLCG2,PTPN6
1.729e-02	-4.06	PRKCA (protein kinase C alpha)	protein interactions	5578	395	4	19454	49	PTPN6,PLCG2,AKAP13,PRKCD
1.732e-02	-4.06	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	13	16828	45	PTPN6,DOCK1,SKAP1,SBNO2,DOCK8,ADCY7,DOCK2,IPCEF1,ELMO1,CSF1R,RGS14,BLNK,WDFY4
1.734e-02	-4.05	kidney	COSMIC cancer mutations	kidney	15380	45	16828	45	WDFY4,GIT2,CSF1R,RHBDF2,TBC1D8,IL6R,MYO1F,DOCK10,DENND1B,APOE,PLCG2,PRKCD,P2RY6,VAV3,NEK6,HIF1A,IRF5,SPI1,AKAP13,DOCK8,HCK,TLN1,STAT6,SBNO2,EHBP1L1,DOCK1,TBXAS1,ADCY7,DOCK2,PIK3R5,PREX1,ARHGAP27,PTPN6,CD74,PARVG,RGS14,BLNK,IPCEF1,ELMO1,GMIP,P2RY2,ARHGAP15,SKAP1,GAB1,ARHGAP33
1.738e-02	-4.05	positive regulation of type I interferon production	biological process	GO:0032481	75	2	18204	49	IRF5,PLCG2
1.738e-02	-4.05	negative regulation of protein secretion	biological process	GO:0050709	75	2	18204	49	APOE,RHBDF2
1.750e-02	-4.05	LAIR1 (leukocyte associated immunoglobulin like receptor 1)	protein interactions	3903	7	1	19454	49	PTPN6
1.750e-02	-4.05	HGD (homogentisate 1,2-dioxygenase)	protein interactions	3081	7	1	19454	49	GIT2
1.750e-02	-4.05	SIGLEC9 (sialic acid binding Ig like lectin 9)	protein interactions	27180	7	1	19454	49	PTPN6
1.750e-02	-4.05	KCNJ1 (potassium inwardly rectifying channel subfamily J member 1)	protein interactions	3758	7	1	19454	49	PRKCD
1.750e-02	-4.05	ERCC6L2 (ERCC excision repair 6 like 2)	protein interactions	375748	7	1	19454	49	NEK6
1.750e-02	-4.05	CDHR3 (cadherin related family member 3)	protein interactions	222256	7	1	19454	49	PARVG
1.750e-02	-4.05	NSUN7 (NOP2/Sun RNA methyltransferase family member 7)	protein interactions	79730	7	1	19454	49	PTPN6
1.750e-02	-4.05	DNAI1 (dynein axonemal intermediate chain 1)	protein interactions	27019	7	1	19454	49	HIF1A
1.752e-02	-4.04	KRTAP1-1 (keratin associated protein 1-1)	protein interactions	81851	218	3	19454	49	P2RY6,HCK,DOCK2
1.774e-02	-4.03	KRTAP3-3 (keratin associated protein 3-3)	protein interactions	85293	81	2	19454	49	P2RY6,DOCK2
1.774e-02	-4.03	MRS2 (magnesium transporter MRS2)	protein interactions	57380	81	2	19454	49	P2RY2,GSDME
1.782e-02	-4.03	alpha-beta T cell differentiation	biological process	GO:0046632	76	2	18204	49	IL6R,STAT6
1.782e-02	-4.03	regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042509	76	2	18204	49	CSF1R,IL6R
1.782e-02	-4.03	regulation of miRNA transcription	biological process	GO:1902893	76	2	18204	49	SPI1,HIF1A
1.782e-02	-4.03	myotube differentiation	biological process	GO:0014902	76	2	18204	49	DOCK2,DOCK1
1.793e-02	-4.02	HEMATOPO_REC_L_F3	prosite domains	PS01354	5	1	12186	44	IL6R
1.804e-02	-4.01	MHC class II protein binding	molecular function	GO:0042289	7	1	18094	47	CD74
1.804e-02	-4.01	hydroperoxy icosatetraenoate dehydratase activity	molecular function	GO:0106256	7	1	18094	47	TBXAS1
1.804e-02	-4.01	interleukin-6 receptor binding	molecular function	GO:0005138	7	1	18094	47	IL6R
1.816e-02	-4.01	BLVRA (biliverdin reductase A)	protein interactions	644	82	2	19454	49	TLN1,PRKCD
1.816e-02	-4.01	STAT6 (signal transducer and activator of transcription 6)	protein interactions	6778	82	2	19454	49	STAT6,PTPN6
1.818e-02	-4.01	Type II interferon signaling (IFNG)	WikiPathways	WP619	37	2	5310	30	SPI1,PRKCD
1.829e-02	-4.00	WH_DNA-bd_sf	interpro domains	IPR036390	211	3	18521	49	SPI1,PREX1,IRF5
1.838e-02	-4.00	STAT_linker	interpro domains	IPR048988	7	1	18521	49	STAT6
1.838e-02	-4.00	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	49	TLN1
1.838e-02	-4.00	Interferon_reg_factor-3	interpro domains	IPR019471	7	1	18521	49	IRF5
1.838e-02	-4.00	STAT_N_sf	interpro domains	IPR036535	7	1	18521	49	STAT6
1.838e-02	-4.00	STAT_TF_prot_interaction	interpro domains	IPR013799	7	1	18521	49	STAT6
1.838e-02	-4.00	GoLoco_motif	interpro domains	IPR003109	7	1	18521	49	RGS14
1.838e-02	-4.00	STAT_TF_DNA-bd_N	interpro domains	IPR012345	7	1	18521	49	STAT6
1.838e-02	-4.00	RBD_dom	interpro domains	IPR003116	7	1	18521	49	RGS14
1.838e-02	-4.00	STAT	interpro domains	IPR001217	7	1	18521	49	STAT6
1.838e-02	-4.00	STAT_TF_alpha	interpro domains	IPR013800	7	1	18521	49	STAT6
1.838e-02	-4.00	STAT_TF_coiled-coil	interpro domains	IPR015988	7	1	18521	49	STAT6
1.838e-02	-4.00	STAT_TF_DNA-bd	interpro domains	IPR013801	7	1	18521	49	STAT6
1.838e-02	-4.00	MYSc_Myo1	interpro domains	IPR036072	7	1	18521	49	MYO1F
1.838e-02	-4.00	PH_16	interpro domains	IPR041020	7	1	18521	49	AKAP13
1.843e-02	-3.99	Paxillin-dependent events mediated by a4b1	Pathway Interaction DB	a4b1_paxdep_pathway	19	2	2226	25	TLN1,DOCK1
1.843e-02	-3.99	cellular response to lipopolysaccharide	biological process	GO:0071222	208	3	18204	49	SBNO2,PLCG2,HCK
1.844e-02	-3.99	negative regulation of phosphate metabolic process	biological process	GO:0045936	377	4	18204	49	PRKCD,RGS14,PTPN6,APOE
1.860e-02	-3.98	negative regulation of phosphorus metabolic process	biological process	GO:0010563	378	4	18204	49	APOE,PRKCD,PTPN6,RGS14
1.864e-02	-3.98	regulation of apoptotic process	biological process	GO:0042981	1518	9	18204	49	GSDME,CSF1R,PRKCD,HIF1A,HCK,CD74,IRF5,DOCK8,PTPN6
1.866e-02	-3.98	positive regulation of canonical NF-kappaB signal transduction	biological process	GO:0043123	209	3	18204	49	NEK6,CD74,AKAP13
1.866e-02	-3.98	regulation of chemotaxis	biological process	GO:0050920	209	3	18204	49	CSF1R,IL6R,CD74
1.869e-02	-3.98	positive regulation of interleukin-23 production	biological process	GO:0032747	7	1	18204	49	PLCG2
1.869e-02	-3.98	macropinocytosis	biological process	GO:0044351	7	1	18204	49	DOCK2
1.869e-02	-3.98	wound healing involved in inflammatory response	biological process	GO:0002246	7	1	18204	49	HIF1A
1.869e-02	-3.98	neural fold formation	biological process	GO:0001842	7	1	18204	49	HIF1A
1.869e-02	-3.98	positive regulation of dendritic cell antigen processing and presentation	biological process	GO:0002606	7	1	18204	49	CD74
1.869e-02	-3.98	interleukin-4-mediated signaling pathway	biological process	GO:0035771	7	1	18204	49	STAT6
1.869e-02	-3.98	positive regulation of activation of Janus kinase activity	biological process	GO:0010536	7	1	18204	49	IL6R
1.869e-02	-3.98	delamination	biological process	GO:0060232	7	1	18204	49	SPI1
1.869e-02	-3.98	positive regulation of glomerular mesangial cell proliferation	biological process	GO:0072126	7	1	18204	49	IL6R
1.869e-02	-3.98	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	49	APOE
1.869e-02	-3.98	regulation of mast cell proliferation	biological process	GO:0070666	7	1	18204	49	STAT6
1.869e-02	-3.98	positive regulation of sphingolipid biosynthetic process	biological process	GO:0090154	7	1	18204	49	PRKCD
1.869e-02	-3.98	regulation of macrophage proliferation	biological process	GO:0120040	7	1	18204	49	CSF1R
1.869e-02	-3.98	positive regulation of ceramide biosynthetic process	biological process	GO:2000304	7	1	18204	49	PRKCD
1.869e-02	-3.98	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	49	APOE
1.869e-02	-3.98	connective tissue replacement	biological process	GO:0097709	7	1	18204	49	HIF1A
1.869e-02	-3.98	response to yeast	biological process	GO:0001878	7	1	18204	49	PLCG2
1.869e-02	-3.98	membrane raft localization	biological process	GO:0051665	7	1	18204	49	DOCK2
1.869e-02	-3.98	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	49	APOE
1.869e-02	-3.98	regulation of phospholipid catabolic process	biological process	GO:0060696	7	1	18204	49	PRKCD
1.869e-02	-3.98	TRAIL-activated apoptotic signaling pathway	biological process	GO:0036462	7	1	18204	49	SPI1
1.869e-02	-3.98	regulation of isotype switching to IgE isotypes	biological process	GO:0048293	7	1	18204	49	STAT6
1.881e-02	-3.97	clathrin-coated vesicle	cellular component	GO:0030136	220	3	19108	49	APOE,DENND1B,CD74
1.900e-02	-3.96	PHLDB3 (pleckstrin homology like domain family B member 3)	protein interactions	653583	84	2	19454	49	SKAP1,GIT2
1.900e-02	-3.96	PPARA (peroxisome proliferator activated receptor alpha)	protein interactions	5465	84	2	19454	49	PRKCD,AKAP13
1.900e-02	-3.96	PER1 (period circadian regulator 1)	protein interactions	5187	84	2	19454	49	SKAP1,HIF1A
1.900e-02	-3.96	KRTAP3-1 (keratin associated protein 3-1)	protein interactions	83896	84	2	19454	49	HCK,DOCK2
1.900e-02	-3.96	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	49	CSF1R,HCK
1.904e-02	-3.96	RINT1 (RAD50 interactor 1)	protein interactions	60561	225	3	19454	49	VAV3,P2RY2,P2RY6
1.912e-02	-3.96	STAT_alpha	pfam domains	PF01017	7	1	17795	49	STAT6
1.912e-02	-3.96	STAT_linker	pfam domains	PF21354	7	1	17795	49	STAT6
1.912e-02	-3.96	IRF-3	pfam domains	PF10401	7	1	17795	49	IRF5
1.912e-02	-3.96	STAT_bind	pfam domains	PF02864	7	1	17795	49	STAT6
1.912e-02	-3.96	STAT_int	pfam domains	PF02865	7	1	17795	49	STAT6
1.912e-02	-3.96	PH_16	pfam domains	PF17838	7	1	17795	49	AKAP13
1.912e-02	-3.96	GoLoco	pfam domains	PF02188	7	1	17795	49	RGS14
1.917e-02	-3.95	positive regulation of blood vessel endothelial cell migration	biological process	GO:0043536	79	2	18204	49	GAB1,HIF1A
1.933e-02	-3.95	I/LWEQ domain	gene3d domains	1.20.1410.10	6	1	14470	47	TLN1
1.934e-02	-3.95	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	9	16828	45	ELMO1,DOCK2,WDFY4,VAV3,SKAP1,ARHGAP15,DOCK1,CD74,DOCK10
1.942e-02	-3.94	cellular response to nitrogen compound	biological process	GO:1901699	580	5	18204	49	P2RY2,PRKCD,P2RY6,STAT6,GAB1
1.942e-02	-3.94	response to virus	biological process	GO:0009615	383	4	18204	49	HIF1A,WDFY4,GSDME,IRF5
1.948e-02	-3.94	PRKCD (protein kinase C delta)	protein interactions	5580	227	3	19454	49	PRKCD,ADCY7,PTPN6
1.959e-02	-3.93	regulation of leukocyte cell-cell adhesion	biological process	GO:1903037	384	4	18204	49	DOCK8,CD74,SKAP1,PTPN6
1.961e-02	-3.93	negative regulation of transferase activity	biological process	GO:0051348	213	3	18204	49	RGS14,PRKCD,APOE
1.963e-02	-3.93	regulation of cytokine production involved in inflammatory response	biological process	GO:1900015	80	2	18204	49	ADCY7,HIF1A
1.980e-02	-3.92	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	8	16828	45	PREX1,TLN1,PLCG2,ARHGAP27,PTPN6,DOCK1,ADCY7,DOCK2
1.993e-02	-3.92	PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase)	protein interactions	5110	229	3	19454	49	DOCK8,APOE,AKAP13
1.998e-02	-3.91	Prkca (protein kinase C, alpha)	protein interactions	24680	8	1	19454	49	AKAP13
1.998e-02	-3.91	HIF3A (hypoxia inducible factor 3 subunit alpha)	protein interactions	64344	8	1	19454	49	HIF1A
1.998e-02	-3.91	TREML1 (triggering receptor expressed on myeloid cells like 1)	protein interactions	340205	8	1	19454	49	PTPN6
1.998e-02	-3.91	Marcks (myristoylated alanine rich protein kinase C substrate)	protein interactions	17118	8	1	19454	49	PRKCD
1.998e-02	-3.91	LILRB1 (leukocyte immunoglobulin like receptor B1)	protein interactions	10859	8	1	19454	49	PTPN6
1.998e-02	-3.91	SSX4 (SSX family member 4)	protein interactions	6759	8	1	19454	49	HIF1A
1.998e-02	-3.91	CD1D (CD1d molecule)	protein interactions	912	8	1	19454	49	CD74
1.998e-02	-3.91	vIRF-3 (vIRF-3)	protein interactions	4961493	8	1	19454	49	HIF1A
2.009e-02	-3.91	regulation of amide metabolic process	biological process	GO:0034248	81	2	18204	49	PRKCD,APOE
2.021e-02	-3.90	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	43	16828	45	PREX1,PTPN6,BLNK,RGS14,ELMO1,IPCEF1,SKAP1,ARHGAP33,GAB1,DENND1B,MYO1F,PLCG2,P2RY6,VAV3,SPI1,DOCK8,TLN1,TBXAS1,DOCK2,ADCY7,PIK3R5,ARHGAP27,PARVG,CD74,GMIP,P2RY2,ARHGAP15,WDFY4,GIT2,CSF1R,TBC1D8,RHBDF2,DOCK10,PRKCD,HIF1A,NEK6,IRF5,AKAP13,STAT6,HCK,EHBP1L1,SBNO2,DOCK1
2.025e-02	-3.90	PTK6 promotes HIF1A stabilization	REACTOME pathways	R-HSA-8857538	6	1	10285	35	HIF1A
2.025e-02	-3.90	CD22 mediated BCR regulation	REACTOME pathways	R-HSA-5690714	6	1	10285	35	PTPN6
2.025e-02	-3.90	MET activates PI3K/AKT signaling	REACTOME pathways	R-HSA-8851907	6	1	10285	35	GAB1
2.027e-02	-3.90	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	14	16828	45	TBXAS1,CSF1R,PIK3R5,PLCG2,PRKCD,PTPN6,P2RY6,VAV3,HIF1A,ELMO1,P2RY2,TLN1,STAT6,GAB1
2.027e-02	-3.90	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	14	16828	45	ELMO1,VAV3,HIF1A,GAB1,TLN1,STAT6,P2RY2,TBXAS1,CSF1R,PTPN6,P2RY6,PLCG2,PRKCD,PIK3R5
2.031e-02	-3.90	apoptotic process	biological process	GO:0006915	1038	7	18204	49	PRKCD,SPI1,DOCK1,IL6R,HIF1A,NEK6,ELMO1
2.034e-02	-3.90	regulation of lymphocyte differentiation	biological process	GO:0045619	216	3	18204	49	SPI1,PTPN6,CD74
2.034e-02	-3.90	regulation of myeloid cell differentiation	biological process	GO:0045637	216	3	18204	49	SPI1,CD74,HIF1A
2.039e-02	-3.89	NBPF19 (NBPF member 19)	protein interactions	101060226	231	3	19454	49	HCK,DOCK2,P2RY6
2.041e-02	-3.89	ovary	COSMIC cancer mutations	ovary	14770	44	16828	45	GMIP,ARHGAP15,P2RY2,ADCY7,DOCK2,TBXAS1,ARHGAP27,CD74,PARVG,PIK3R5,AKAP13,HIF1A,NEK6,IRF5,EHBP1L1,SBNO2,DOCK1,HCK,STAT6,RHBDF2,TBC1D8,WDFY4,CSF1R,GIT2,APOE,PRKCD,DOCK10,IPCEF1,ELMO1,RGS14,BLNK,SKAP1,GAB1,ARHGAP33,PTPN6,PREX1,SPI1,VAV3,DOCK8,TLN1,PLCG2,P2RY6,IL6R,MYO1F
2.044e-02	-3.89	RHOJ (ras homolog family member J)	protein interactions	57381	628	5	19454	49	DOCK8,TBC1D8,GAB1,DOCK10,GIT2
2.056e-02	-3.88	granulocyte chemotaxis	biological process	GO:0071621	82	2	18204	49	PREX1,VAV3
2.056e-02	-3.88	antioxidant activity	molecular function	GO:0016209	85	2	18094	47	IPCEF1,APOE
2.059e-02	-3.88	positive regulation of cellular catabolic process	biological process	GO:0031331	217	3	18204	49	APOE,HIF1A,PRKCD
2.059e-02	-3.88	negative regulation of protein localization	biological process	GO:1903828	217	3	18204	49	RHBDF2,APOE,SPI1
2.060e-02	-3.88	transcription regulator activator activity	molecular function	GO:0140537	8	1	18094	47	HIF1A
2.060e-02	-3.88	adenosine receptor binding	molecular function	GO:0031685	8	1	18094	47	P2RY2
2.060e-02	-3.88	CD4 receptor binding	molecular function	GO:0042609	8	1	18094	47	CD74
2.062e-02	-3.88	BCR (BCR activator of RhoGEF and GTPase)	protein interactions	613	232	3	19454	49	HIF1A,PTPN6,HCK
2.073e-02	-3.88	PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta)	protein interactions	5291	88	2	19454	49	PRKCD,HCK
2.079e-02	-3.87	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	5	14470	47	NRK,CSF1R,HCK,NEK6,PRKCD
2.084e-02	-3.87	dendrite	cellular component	GO:0030425	620	5	19108	49	ARHGAP33,RGS14,APOE,PREX1,DOCK10
2.097e-02	-3.86	Adcy	interpro domains	IPR030672	8	1	18521	49	ADCY7
2.097e-02	-3.86	AC_N	interpro domains	IPR032628	8	1	18521	49	ADCY7
2.097e-02	-3.86	Myosin_TH1	interpro domains	IPR010926	8	1	18521	49	MYO1F
2.097e-02	-3.86	Tyr_kinase_rcpt_3_CS	interpro domains	IPR001824	8	1	18521	49	CSF1R
2.097e-02	-3.86	bMERB_dom	interpro domains	IPR022735	8	1	18521	49	EHBP1L1
2.097e-02	-3.86	TypeI_recpt_CBD	interpro domains	IPR015321	8	1	18521	49	IL6R
2.097e-02	-3.86	PH-BEACH_dom	interpro domains	IPR023362	8	1	18521	49	WDFY4
2.110e-02	-3.86	dendritic tree	cellular component	GO:0097447	622	5	19108	49	APOE,PREX1,DOCK10,ARHGAP33,RGS14
2.117e-02	-3.85	INSRR (insulin receptor related receptor)	protein interactions	3645	89	2	19454	49	RHBDF2,PRKCD
2.120e-02	-3.85	haematopoietic_and_lymphoid_tissue-other-normal	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-other-normal	8	1	16828	45	CSF1R
2.130e-02	-3.85	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	11	16828	45	GAB1,DOCK1,ARHGAP15,SKAP1,VAV3,AKAP13,IPCEF1,GMIP,ELMO1,DOCK10,DOCK2
2.130e-02	-3.85	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	11	16828	45	VAV3,AKAP13,DOCK2,IPCEF1,GMIP,ELMO1,DOCK10,GAB1,DOCK1,ARHGAP15,SKAP1
2.134e-02	-3.85	intracellular oxygen homeostasis	biological process	GO:0032364	8	1	18204	49	HIF1A
2.134e-02	-3.85	G protein-coupled receptor signaling pathway involved in heart process	biological process	GO:0086103	8	1	18204	49	AKAP13
2.134e-02	-3.85	positive regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001280	8	1	18204	49	CD74
2.134e-02	-3.85	cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:0036006	8	1	18204	49	CSF1R
2.134e-02	-3.85	multinuclear osteoclast differentiation	biological process	GO:0072674	8	1	18204	49	SBNO2
2.134e-02	-3.85	mitotic nuclear membrane disassembly	biological process	GO:0007077	8	1	18204	49	NEK6
2.134e-02	-3.85	regulation of I-kappaB phosphorylation	biological process	GO:1903719	8	1	18204	49	PLCG2
2.134e-02	-3.85	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	49	APOE
2.134e-02	-3.85	protein import	biological process	GO:0017038	8	1	18204	49	APOE
2.134e-02	-3.85	regulation of endodeoxyribonuclease activity	biological process	GO:0032071	8	1	18204	49	PRKCD
2.134e-02	-3.85	regulation of activation of Janus kinase activity	biological process	GO:0010533	8	1	18204	49	IL6R
2.134e-02	-3.85	regulation of neutrophil degranulation	biological process	GO:0043313	8	1	18204	49	SPI1
2.134e-02	-3.85	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	49	APOE
2.134e-02	-3.85	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	49	APOE
2.134e-02	-3.85	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	49	APOE
2.134e-02	-3.85	regulation of transforming growth factor beta2 production	biological process	GO:0032909	8	1	18204	49	HIF1A
2.138e-02	-3.85	nuclear speck	cellular component	GO:0016607	414	4	19108	49	NEK6,HIF1A,DENND1B,DOCK1
2.147e-02	-3.84	ELMO	prosite domains	PS51335	6	1	12186	44	ELMO1
2.151e-02	-3.84	regulation of release of sequestered calcium ion into cytosol	biological process	GO:0051279	84	2	18204	49	P2RY6,PTPN6
2.152e-02	-3.84	astrocytoma_Grade_II	COSMIC cancer mutations	astrocytoma_Grade_II	601	5	16828	45	SBNO2,PREX1,TLN1,RGS14,WDFY4
2.159e-02	-3.84	cellular response to molecule of bacterial origin	biological process	GO:0071219	221	3	18204	49	SBNO2,PLCG2,HCK
2.162e-02	-3.83	IPO13 (importin 13)	protein interactions	9670	90	2	19454	49	CD74,P2RY6
2.165e-02	-3.83	regulation of apoptotic signaling pathway	biological process	GO:2001233	396	4	18204	49	PRKCD,HIF1A,CD74,GSDME
2.180e-02	-3.83	PPP6R3 (protein phosphatase 6 regulatory subunit 3)	protein interactions	55291	237	3	19454	49	IRF5,P2RY6,CD74
2.182e-02	-3.82	Myosin_TH1	pfam domains	PF06017	8	1	17795	49	MYO1F
2.182e-02	-3.82	IL6Ra-bind	pfam domains	PF09240	8	1	17795	49	IL6R
2.182e-02	-3.82	bMERB_dom	pfam domains	PF12130	8	1	17795	49	EHBP1L1
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY7
2.207e-02	-3.81	KDELR1 (KDEL endoplasmic reticulum protein retention receptor 1)	protein interactions	10945	91	2	19454	49	NEK6,P2RY2
2.227e-02	-3.80	human chr6q25.2	chromosome location	human chr6q25.2	12	1	26134	49	IPCEF1
2.241e-02	-3.80	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	47	APOE,CD74
2.245e-02	-3.80	ARHGAP33 (Rho GTPase activating protein 33)	protein interactions	115703	9	1	19454	49	NEK6
2.245e-02	-3.80	ADCY7 (adenylate cyclase 7)	protein interactions	113	9	1	19454	49	PRKCD
2.245e-02	-3.80	HLA-DMA (major histocompatibility complex, class II, DM alpha)	protein interactions	3108	9	1	19454	49	CD74
2.245e-02	-3.80	KLRA1P (killer cell lectin like receptor A1, pseudogene)	protein interactions	10748	9	1	19454	49	PTPN6
2.245e-02	-3.80	RWDD3 (RWD domain containing 3)	protein interactions	25950	9	1	19454	49	HIF1A
2.245e-02	-3.80	LILRB2 (leukocyte immunoglobulin like receptor B2)	protein interactions	10288	9	1	19454	49	PTPN6
2.245e-02	-3.80	DUX3 (double homeobox 3)	protein interactions	26582	9	1	19454	49	PRKCD
2.245e-02	-3.80	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	49	APOE
2.245e-02	-3.80	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	49	APOE
2.247e-02	-3.80	positive regulation of lipid transport	biological process	GO:0032370	86	2	18204	49	APOE,PRKCD
2.252e-02	-3.79	STAT transcription factor, all-alpha domain	gene3d domains	1.20.1050.20	7	1	14470	47	STAT6
2.252e-02	-3.79	STAT transcription factor, DNA-binding domain	gene3d domains	2.60.40.630	7	1	14470	47	STAT6
2.253e-02	-3.79	SLC1A5 (solute carrier family 1 member 5)	protein interactions	6510	240	3	19454	49	P2RY6,NEK6,RHBDF2
2.253e-02	-3.79	ARHGEF16 (Rho guanine nucleotide exchange factor 16)	protein interactions	27237	92	2	19454	49	ELMO1,PRKCD
2.262e-02	-3.79	striated muscle cell differentiation	biological process	GO:0051146	225	3	18204	49	DOCK2,DOCK1,AKAP13
2.264e-02	-3.79	ACTG1 (actin gamma 1)	protein interactions	71	429	4	19454	49	ARHGAP27,GSDME,GIT2,APOE
2.266e-02	-3.79	Pathways in cancer	KEGG pathways	hsa05200	395	5	7161	30	CSF1R,PLCG2,SPI1,HIF1A,ADCY7
2.285e-02	-3.78	phosphatidylinositol 3-kinase complex, class I	cellular component	GO:0097651	9	1	19108	49	PIK3R5
2.285e-02	-3.78	phosphatidylinositol 3-kinase complex, class IA	cellular component	GO:0005943	9	1	19108	49	PIK3R5
2.285e-02	-3.78	unconventional myosin complex	cellular component	GO:0016461	9	1	19108	49	MYO1F
2.288e-02	-3.78	anatomical structure development	biological process	GO:0048856	5207	21	18204	49	VAV3,PREX1,DOCK1,SPI1,CD74,IL6R,HIF1A,BLNK,DOCK2,DOCK10,AKAP13,PTPN6,GAB1,GSDME,CSF1R,SBNO2,STAT6,HCK,GIT2,APOE,PLCG2
2.288e-02	-3.78	Focal Adhesion	WikiPathways	WP306	195	4	5310	30	HCK,TLN1,DOCK1,PIK3R5
2.289e-02	-3.78	Interferon alpha/beta signaling	REACTOME pathways	R-HSA-909733	69	2	10285	35	IRF5,PTPN6
2.296e-02	-3.77	modulation by host of symbiont process	biological process	GO:0051851	87	2	18204	49	APOE,CSF1R
2.296e-02	-3.77	associative learning	biological process	GO:0008306	87	2	18204	49	RGS14,HIF1A
2.313e-02	-3.77	C20 prostanoid biosynthesis	BIOCYC pathways	HUMAN_PWY66-374	7	1	902	3	TBXAS1
2.313e-02	-3.77	C20 prostanoid biosynthesis	BIOCYC pathways	META_PWY66-374	7	1	902	3	TBXAS1
2.316e-02	-3.77	KRT40 (keratin 40)	protein interactions	125115	432	4	19454	49	DOCK8,HCK,DOCK2,NEK6
2.334e-02	-3.76	arm	COSMIC cancer mutations	arm	1331	8	16828	45	CSF1R,MYO1F,STAT6,DOCK8,BLNK,ADCY7,ARHGAP33,PRKCD
2.341e-02	-3.75	cellular response to oxidative stress	biological process	GO:0034599	228	3	18204	49	STAT6,HIF1A,PRKCD
2.342e-02	-3.75	WH-like_DNA-bd_sf	interpro domains	IPR036388	232	3	18521	49	PREX1,SPI1,IRF5
2.344e-02	-3.75	Neurotrophic factor-mediated Trk receptor signaling	Pathway Interaction DB	trkrpathway	56	3	2226	25	DOCK1,GAB1,ELMO1
2.345e-02	-3.75	ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase)	protein interactions	6098	94	2	19454	49	VAV3,PTPN6
2.345e-02	-3.75	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	49	ELMO1,DOCK1
2.345e-02	-3.75	NUAK1 (NUAK family kinase 1)	protein interactions	9891	94	2	19454	49	DOCK1,ELMO1
2.357e-02	-3.75	Interferon_reg_fact_DNA-bd_dom	interpro domains	IPR001346	9	1	18521	49	IRF5
2.357e-02	-3.75	BEACH_dom_sf	interpro domains	IPR036372	9	1	18521	49	WDFY4
2.357e-02	-3.75	Peptidase_S54_rhomboid_dom	interpro domains	IPR022764	9	1	18521	49	RHBDF2
2.357e-02	-3.75	Interferon_reg_fac_CS	interpro domains	IPR019817	9	1	18521	49	IRF5
2.357e-02	-3.75	BEACH_dom	interpro domains	IPR000409	9	1	18521	49	WDFY4
2.359e-02	-3.75	Activation of NIMA Kinases NEK9, NEK6, NEK7	REACTOME pathways	R-HSA-2980767	7	1	10285	35	NEK6
2.363e-02	-3.75	focal adhesion	cellular component	GO:0005925	427	4	19108	49	TLN1,PARVG,GIT2,HCK
2.376e-02	-3.74	clathrin-coated endocytic vesicle	cellular component	GO:0045334	93	2	19108	49	CD74,APOE
2.381e-02	-3.74	cell leading edge	cellular component	GO:0031252	428	4	19108	49	DOCK8,CARMIL3,PLCG2,TLN1
2.397e-02	-3.73	sterol catabolic process	biological process	GO:0016127	9	1	18204	49	APOE
2.397e-02	-3.73	regulation of sarcomere organization	biological process	GO:0060297	9	1	18204	49	AKAP13
2.397e-02	-3.73	cellular response to hydroperoxide	biological process	GO:0071447	9	1	18204	49	PRKCD
2.397e-02	-3.73	iris morphogenesis	biological process	GO:0061072	9	1	18204	49	HIF1A
2.397e-02	-3.73	establishment of T cell polarity	biological process	GO:0001768	9	1	18204	49	DOCK2
2.397e-02	-3.73	transepithelial chloride transport	biological process	GO:0030321	9	1	18204	49	P2RY6
2.397e-02	-3.73	marginal zone B cell differentiation	biological process	GO:0002315	9	1	18204	49	DOCK10
2.397e-02	-3.73	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	49	APOE
2.397e-02	-3.73	negative regulation of inflammatory response to wounding	biological process	GO:0106015	9	1	18204	49	PTPN6
2.397e-02	-3.73	T-helper 17 cell lineage commitment	biological process	GO:0072540	9	1	18204	49	IL6R
2.397e-02	-3.73	respiratory burst involved in defense response	biological process	GO:0002679	9	1	18204	49	HCK
2.397e-02	-3.73	positive regulation of cell proliferation involved in kidney development	biological process	GO:1901724	9	1	18204	49	IL6R
2.397e-02	-3.73	regulation of mucus secretion	biological process	GO:0070255	9	1	18204	49	P2RY2
2.397e-02	-3.73	regulation of protein localization to chromatin	biological process	GO:1905634	9	1	18204	49	SPI1
2.397e-02	-3.73	cyclooxygenase pathway	biological process	GO:0019371	9	1	18204	49	TBXAS1
2.397e-02	-3.73	positive regulation of hormone biosynthetic process	biological process	GO:0046886	9	1	18204	49	HIF1A
2.397e-02	-3.73	macrophage proliferation	biological process	GO:0061517	9	1	18204	49	CSF1R
2.397e-02	-3.73	positive regulation of antigen processing and presentation	biological process	GO:0002579	9	1	18204	49	CD74
2.397e-02	-3.73	negative regulation of thymocyte apoptotic process	biological process	GO:0070244	9	1	18204	49	HIF1A
2.397e-02	-3.73	microglial cell proliferation	biological process	GO:0061518	9	1	18204	49	CSF1R
2.397e-02	-3.73	positive regulation of T-helper 2 cell cytokine production	biological process	GO:2000553	9	1	18204	49	DENND1B
2.397e-02	-3.73	glandular epithelial cell maturation	biological process	GO:0002071	9	1	18204	49	HIF1A
2.438e-02	-3.71	KCTD5 (potassium channel tetramerization domain containing 5)	protein interactions	54442	96	2	19454	49	NEK6,GIT2
2.438e-02	-3.71	RLIM (ring finger protein, LIM domain interacting)	protein interactions	51132	96	2	19454	49	STAT6,HIF1A
2.439e-02	-3.71	GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)	protein interactions	8729	439	4	19454	49	TLN1,GSDME,HIF1A,PTPN6
2.446e-02	-3.71	regulation of Rho protein signal transduction	biological process	GO:0035023	90	2	18204	49	APOE,AKAP13
2.452e-02	-3.71	Rhomboid	pfam domains	PF01694	9	1	17795	49	RHBDF2
2.452e-02	-3.71	IRF	pfam domains	PF00605	9	1	17795	49	IRF5
2.452e-02	-3.71	Beach	pfam domains	PF02138	9	1	17795	49	WDFY4
2.476e-02	-3.70	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	6	16828	45	DOCK2,ELMO1,ARHGAP15,NEK6,VAV3,DOCK8
2.486e-02	-3.69	SOCS3 (suppressor of cytokine signaling 3)	protein interactions	9021	97	2	19454	49	GAB1,CSF1R
2.491e-02	-3.69	PGA4 (pepsinogen A4)	protein interactions	643847	10	1	19454	49	CD74
2.491e-02	-3.69	GPLD1 (glycosylphosphatidylinositol specific phospholipase D1)	protein interactions	2822	10	1	19454	49	HIF1A
2.491e-02	-3.69	SIGLEC7 (sialic acid binding Ig like lectin 7)	protein interactions	27036	10	1	19454	49	PTPN6
2.491e-02	-3.69	IPCEF1 (interaction protein for cytohesin exchange factors 1)	protein interactions	26034	10	1	19454	49	DOCK1
2.491e-02	-3.69	SIGLEC10 (sialic acid binding Ig like lectin 10)	protein interactions	89790	10	1	19454	49	PTPN6
2.491e-02	-3.69	NRAP (nebulin related anchoring protein)	protein interactions	4892	10	1	19454	49	TLN1
2.491e-02	-3.69	IL11 (interleukin 11)	protein interactions	3589	10	1	19454	49	HIF1A
2.491e-02	-3.69	FCER2 (Fc epsilon receptor II)	protein interactions	2208	10	1	19454	49	STAT6
2.496e-02	-3.69	regulation of miRNA metabolic process	biological process	GO:2000628	91	2	18204	49	SPI1,HIF1A
2.496e-02	-3.69	cellular oxidant detoxification	biological process	GO:0098869	91	2	18204	49	IPCEF1,APOE
2.501e-02	-3.69	RBD	prosite domains	PS50898	7	1	12186	44	RGS14
2.501e-02	-3.69	GOLOCO	prosite domains	PS50877	7	1	12186	44	RGS14
2.534e-02	-3.68	Ion Channel and Phorbal Esters Signaling Pathway	SMPDB pathways	SMP0090032	5	1	1369	7	P2RY2
2.546e-02	-3.67	cell-substrate junction	cellular component	GO:0030055	437	4	19108	49	HCK,GIT2,PARVG,TLN1
2.548e-02	-3.67	positive regulation of transporter activity	biological process	GO:0032411	92	2	18204	49	PRKCD,P2RY6
2.548e-02	-3.67	positive regulation of mononuclear cell migration	biological process	GO:0071677	92	2	18204	49	CSF1R,DOCK8
2.555e-02	-3.67	DCAF15 (DDB1 and CUL4 associated factor 15)	protein interactions	90379	252	3	19454	49	TLN1,EHBP1L1,DOCK2
2.555e-02	-3.67	PSMD7 (proteasome 26S subunit, non-ATPase 7)	protein interactions	5713	252	3	19454	49	PTPN6,PREX1,P2RY6
2.559e-02	-3.67	regulation of endothelial cell migration	biological process	GO:0010594	236	3	18204	49	GAB1,APOE,HIF1A
2.578e-02	-3.66	blood circulation	biological process	GO:0008015	418	4	18204	49	TBXAS1,APOE,P2RY2,TBC1D8
2.582e-02	-3.66	XPO4 (exportin 4)	protein interactions	64328	99	2	19454	49	P2RY6,P2RY2
2.582e-02	-3.66	FHL5 (four and a half LIM domains 5)	protein interactions	9457	99	2	19454	49	NEK6,HCK
2.587e-02	-3.65	regulation of lymphocyte proliferation	biological process	GO:0050670	237	3	18204	49	VAV3,PTPN6,CD74
2.589e-02	-3.65	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	31	16828	45	RHBDF2,CSF1R,WDFY4,P2RY6,APOE,PLCG2,PRKCD,DOCK10,MYO1F,AKAP13,VAV3,NEK6,IRF5,DOCK1,HCK,TLN1,STAT6,DOCK8,ADCY7,DOCK2,PTPN6,PREX1,PIK3R5,IPCEF1,ELMO1,BLNK,GAB1,ARHGAP33,ARHGAP15,SKAP1,P2RY2
2.615e-02	-3.64	PAS_fold_3	interpro domains	IPR013655	10	1	18521	49	HIF1A
2.616e-02	-3.64	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	49	FYB1,RHBDF2,SKAP1
2.619e-02	-3.64	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	49	CSF1R,HCK
2.621e-02	-3.64	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-femur-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	633	5	16828	45	DOCK10,PREX1,P2RY2,AKAP13,RHBDF2
2.630e-02	-3.64	cytokine receptor activity	molecular function	GO:0004896	97	2	18094	47	CD74,IL6R
2.630e-02	-3.64	PTK6 (protein tyrosine kinase 6)	protein interactions	5753	100	2	19454	49	HIF1A,GAB1
2.630e-02	-3.64	SKAP1 (src kinase associated phosphoprotein 1)	protein interactions	8631	100	2	19454	49	SKAP1,FYB1
2.630e-02	-3.64	MUL1 (mitochondrial E3 ubiquitin protein ligase 1)	protein interactions	79594	100	2	19454	49	TBC1D8,GSDME
2.638e-02	-3.64	negative regulation of protein modification process	biological process	GO:0031400	421	4	18204	49	PRKCD,RGS14,PTPN6,APOE
2.660e-02	-3.63	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	49	APOE
2.660e-02	-3.63	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	49	APOE
2.660e-02	-3.63	endothelial cell chemotaxis	biological process	GO:0035767	10	1	18204	49	GAB1
2.660e-02	-3.63	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	49	APOE
2.660e-02	-3.63	establishment of lymphocyte polarity	biological process	GO:0001767	10	1	18204	49	DOCK2
2.660e-02	-3.63	regulation of interleukin-23 production	biological process	GO:0032667	10	1	18204	49	PLCG2
2.660e-02	-3.63	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	49	APOE
2.660e-02	-3.63	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	49	APOE
2.660e-02	-3.63	negative regulation of mast cell activation	biological process	GO:0033004	10	1	18204	49	PTPN6
2.660e-02	-3.63	intracellular monoatomic anion homeostasis	biological process	GO:0030002	10	1	18204	49	TBXAS1
2.660e-02	-3.63	regulation of deoxyribonuclease activity	biological process	GO:0032070	10	1	18204	49	PRKCD
2.660e-02	-3.63	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	49	APOE
2.660e-02	-3.63	negative regulation of glial cell apoptotic process	biological process	GO:0034351	10	1	18204	49	PRKCD
2.660e-02	-3.63	intracellular chloride ion homeostasis	biological process	GO:0030644	10	1	18204	49	TBXAS1
2.660e-02	-3.63	growth hormone receptor signaling pathway via JAK-STAT	biological process	GO:0060397	10	1	18204	49	STAT6
2.660e-02	-3.63	integrin activation	biological process	GO:0033622	10	1	18204	49	TLN1
2.660e-02	-3.63	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	49	ADCY7
2.660e-02	-3.63	positive regulation of monocyte differentiation	biological process	GO:0045657	10	1	18204	49	CD74
2.660e-02	-3.63	hemoglobin metabolic process	biological process	GO:0020027	10	1	18204	49	HIF1A
2.678e-02	-3.62	Jak-STAT signaling pathway	KEGG pathways	ko04630	156	3	7161	30	PTPN6,IL6R,STAT6
2.678e-02	-3.62	Jak-STAT signaling pathway	KEGG pathways	hsa04630	156	3	7161	30	STAT6,PTPN6,IL6R
2.679e-02	-3.62	FBXO28 (F-box protein 28)	protein interactions	23219	101	2	19454	49	GIT2,HIF1A
2.679e-02	-3.62	BMAL1 (basic helix-loop-helix ARNT like 1)	protein interactions	406	101	2	19454	49	GIT2,HIF1A
2.679e-02	-3.62	MYO9B (myosin IXB)	protein interactions	4650	101	2	19454	49	SKAP1,HIF1A
2.679e-02	-3.62	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	49	PTPN6,RHBDF2
2.691e-02	-3.62	HuR (ELAVL1) binds and stabilizes mRNA	REACTOME pathways	R-HSA-450520	8	1	10285	35	PRKCD
2.696e-02	-3.61	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	6	16828	45	ADCY7,PRKCD,RHBDF2,NEK6,HCK,CSF1R
2.706e-02	-3.61	G alpha (q) signalling events	REACTOME pathways	R-HSA-416476	192	3	10285	35	PRKCD,P2RY2,P2RY6
2.714e-02	-3.61	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	11	16828	45	SPI1,BLNK,RGS14,NEK6,GIT2,CSF1R,PRKCD,DOCK1,P2RY2,STAT6,HCK
2.718e-02	-3.61	regulation of hemopoiesis	biological process	GO:1903706	425	4	18204	49	PTPN6,SPI1,CD74,HIF1A
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	HIF1A
2.728e-02	-3.60	FASLG (Fas ligand)	protein interactions	356	102	2	19454	49	FYB1,HCK
2.730e-02	-3.60	regulation of mononuclear cell proliferation	biological process	GO:0032944	242	3	18204	49	PTPN6,CD74,VAV3
2.735e-02	-3.60	FGFR4 (fibroblast growth factor receptor 4)	protein interactions	2264	455	4	19454	49	P2RY6,HIF1A,GAB1,PTPN6
2.737e-02	-3.60	ADGRG2 (adhesion G protein-coupled receptor G2)	protein interactions	10149	11	1	19454	49	GMIP
2.737e-02	-3.60	GHSR (growth hormone secretagogue receptor)	protein interactions	2693	11	1	19454	49	P2RY6
2.737e-02	-3.60	ZNF407 (zinc finger protein 407)	protein interactions	55628	11	1	19454	49	STAT6
2.737e-02	-3.60	FERRY3 (FERRY endosomal RAB5 effector complex subunit 3)	protein interactions	57102	11	1	19454	49	IL6R
2.737e-02	-3.60	FMO1 (flavin containing dimethylaniline monoxygenase 1)	protein interactions	2326	11	1	19454	49	TLN1
2.737e-02	-3.60	NYAP1 (neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1)	protein interactions	222950	11	1	19454	49	TLN1
2.737e-02	-3.60	KLHL32 (kelch like family member 32)	protein interactions	114792	11	1	19454	49	PARVG
2.737e-02	-3.60	RGCC (regulator of cell cycle)	protein interactions	28984	11	1	19454	49	TLN1
2.737e-02	-3.60	CYP1A2 (cytochrome P450 family 1 subfamily A member 2)	protein interactions	1544	11	1	19454	49	HIF1A
2.748e-02	-3.59	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	45	NEK6,HCK,CSF1R,PRKCD
2.748e-02	-3.59	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	45	PRKCD,HCK,CSF1R,NEK6
2.752e-02	-3.59	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	11	19108	49	RGS14,APOE,DOCK8,TLN1,PREX1,HIF1A,PLCG2,ARHGAP33,DOCK10,CARMIL3,MYO1F
2.756e-02	-3.59	granulocyte migration	biological process	GO:0097530	96	2	18204	49	PREX1,VAV3
2.769e-02	-3.59	ruffle membrane	cellular component	GO:0032587	101	2	19108	49	TLN1,PLCG2
2.777e-02	-3.58	human chr14q23.2	chromosome location	human chr14q23.2	15	1	26134	49	HIF1A
2.777e-02	-3.58	human chr9p24.3	chromosome location	human chr9p24.3	15	1	26134	49	DOCK8
2.777e-02	-3.58	GoLoco	smart domains	SM00390	7	1	9717	39	RGS14
2.777e-02	-3.58	RBD	smart domains	SM00455	7	1	9717	39	RGS14
2.777e-02	-3.58	STAT_int	smart domains	SM00964	7	1	9717	39	STAT6
2.777e-02	-3.58	IRF-3	smart domains	SM01243	7	1	9717	39	IRF5
2.778e-02	-3.58	PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1)	protein interactions	54704	103	2	19454	49	HIF1A,PRKCD
2.809e-02	-3.57	IL4-mediated signaling events	Pathway Interaction DB	il4_2pathway	60	3	2226	25	PTPN6,SPI1,STAT6
2.810e-02	-3.57	leukocyte homeostasis	biological process	GO:0001776	97	2	18204	49	HIF1A,DOCK10
2.821e-02	-3.57	nitric-oxide synthase binding	molecular function	GO:0050998	11	1	18094	47	CD74
2.821e-02	-3.57	GTPase activating protein binding	molecular function	GO:0032794	11	1	18094	47	RGS14
2.821e-02	-3.57	cardiolipin binding	molecular function	GO:1901612	11	1	18094	47	GSDME
2.821e-02	-3.57	T cell receptor binding	molecular function	GO:0042608	11	1	18094	47	DOCK2
2.821e-02	-3.57	STAT family protein binding	molecular function	GO:0097677	11	1	18094	47	SPI1
2.828e-02	-3.57	GRK2 (G protein-coupled receptor kinase 2)	protein interactions	156	104	2	19454	49	GIT2,PRKCD
2.832e-02	-3.56	IGF1R (insulin like growth factor 1 receptor)	protein interactions	3480	460	4	19454	49	VAV3,PRKCD,PTPN6,GAB1
2.847e-02	-3.56	regulation of cell morphogenesis	biological process	GO:0022604	246	3	18204	49	ARHGAP15,HCK,CSF1R
2.847e-02	-3.56	response to toxic substance	biological process	GO:0009636	246	3	18204	49	APOE,IPCEF1,ARHGAP33
2.850e-02	-3.56	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway	WikiPathways	WP2203	47	2	5310	30	STAT6,HCK
2.851e-02	-3.56	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	5	12186	44	NEK6,HCK,CSF1R,PRKCD,NRK
2.853e-02	-3.56	RECEPTOR_TYR_KIN_III	prosite domains	PS00240	8	1	12186	44	CSF1R
2.853e-02	-3.56	TH1	prosite domains	PS51757	8	1	12186	44	MYO1F
2.853e-02	-3.56	BMERB	prosite domains	PS51848	8	1	12186	44	EHBP1L1
2.853e-02	-3.56	PH_BEACH	prosite domains	PS51783	8	1	12186	44	WDFY4
2.863e-02	-3.55	response to hydrogen peroxide	biological process	GO:0042542	98	2	18204	49	STAT6,PRKCD
2.873e-02	-3.55	SM22_calponin	interpro domains	IPR003096	11	1	18521	49	VAV3
2.875e-02	-3.55	APP (amyloid beta precursor protein)	protein interactions	351	2342	11	19454	49	APOE,P2RY2,HCK,PIK3R5,ARHGAP15,PRKCD,RGS14,CD74,PARVG,AKAP13,SKAP1
2.877e-02	-3.55	cellular response to biotic stimulus	biological process	GO:0071216	247	3	18204	49	HCK,PLCG2,SBNO2
2.885e-02	-3.55	regulation of protein transport	biological process	GO:0051223	433	4	18204	49	PRKCD,HIF1A,RHBDF2,APOE
2.886e-02	-3.55	BEACH domain	gene3d domains	1.10.1540.10	9	1	14470	47	WDFY4
2.886e-02	-3.55	Nucleotidyltransferases domain 2	gene3d domains	1.20.120.330	9	1	14470	47	GIT2
2.892e-02	-3.54	INTFRNREGFCT	prints domains	PR00267	9	1	5227	17	IRF5
2.908e-02	-3.54	small_intestine	COSMIC cancer mutations	small_intestine	250	3	16828	45	PREX1,CSF1R,ARHGAP33
2.913e-02	-3.54	Renal cell carcinoma	KEGG pathways	hsa05211	64	2	7161	30	GAB1,HIF1A
2.913e-02	-3.54	Shigellosis	KEGG pathways	hsa05131	64	2	7161	30	DOCK1,ELMO1
2.913e-02	-3.54	Renal cell carcinoma	KEGG pathways	ko05211	64	2	7161	30	GAB1,HIF1A
2.917e-02	-3.53	activation of GTPase activity	biological process	GO:0090630	99	2	18204	49	GMIP,TBC1D8
2.917e-02	-3.53	regulation of signaling receptor activity	biological process	GO:0010469	99	2	18204	49	PRKCD,HIF1A
2.922e-02	-3.53	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	49	APOE
2.922e-02	-3.53	pinocytosis	biological process	GO:0006907	11	1	18204	49	DOCK2
2.922e-02	-3.53	negative regulation of mesenchymal cell apoptotic process	biological process	GO:2001054	11	1	18204	49	HIF1A
2.922e-02	-3.53	regulation of cell-cell adhesion mediated by integrin	biological process	GO:0033632	11	1	18204	49	SKAP1
2.922e-02	-3.53	regulation of dendritic cell antigen processing and presentation	biological process	GO:0002604	11	1	18204	49	CD74
2.922e-02	-3.53	CD8-positive, alpha-beta T cell activation	biological process	GO:0036037	11	1	18204	49	WDFY4
2.922e-02	-3.53	negative regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002924	11	1	18204	49	PTPN6
2.922e-02	-3.53	pericyte cell differentiation	biological process	GO:1904238	11	1	18204	49	SPI1
2.922e-02	-3.53	positive regulation of integrin activation	biological process	GO:0033625	11	1	18204	49	SKAP1
2.922e-02	-3.53	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	49	APOE
2.922e-02	-3.53	regulation of fear response	biological process	GO:1903365	11	1	18204	49	APOE
2.922e-02	-3.53	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	49	PRKCD
2.922e-02	-3.53	negative regulation of myeloid leukocyte mediated immunity	biological process	GO:0002887	11	1	18204	49	SPI1
2.922e-02	-3.53	positive regulation of chemokine (C-X-C motif) ligand 2 production	biological process	GO:2000343	11	1	18204	49	CD74
2.927e-02	-3.53	blood vessel morphogenesis	biological process	GO:0048514	435	4	18204	49	VAV3,APOE,GAB1,HIF1A
2.929e-02	-3.53	PTN (pleiotrophin)	protein interactions	5764	106	2	19454	49	GSDME,NEK6
2.935e-02	-3.53	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	45	NEK6,HCK,CSF1R,PRKCD
2.946e-02	-3.52	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	5	16828	45	DOCK10,STAT6,WDFY4,SKAP1,ELMO1
2.951e-02	-3.52	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	49	DOCK8,AKAP13,DOCK1,GIT2
2.963e-02	-3.52	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	5	16828	45	SKAP1,ELMO1,WDFY4,STAT6,DOCK10
2.964e-02	-3.52	Differentiation Pathway	WikiPathways	WP2848	48	2	5310	30	CSF1R,IL6R
2.967e-02	-3.52	cellular response to peptide hormone stimulus	biological process	GO:0071375	250	3	18204	49	STAT6,PRKCD,GAB1
2.967e-02	-3.52	D-myo-inositol-5-phosphate metabolism	BIOCYC pathways	META_PWY-6367	9	1	902	3	PLCG2
2.970e-02	-3.52	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	4	18204	49	P2RY2,HIF1A,TBXAS1,APOE
2.972e-02	-3.52	hematopoietic progenitor cell differentiation	biological process	GO:0002244	100	2	18204	49	SPI1,PTPN6
2.972e-02	-3.52	positive regulation of smooth muscle cell proliferation	biological process	GO:0048661	100	2	18204	49	P2RY6,IL6R
2.980e-02	-3.51	RPL39 (ribosomal protein L39)	protein interactions	6170	107	2	19454	49	P2RY6,PTPN6
2.980e-02	-3.51	TPP2 (tripeptidyl peptidase 2)	protein interactions	7174	107	2	19454	49	P2RY6,CD74
2.982e-02	-3.51	NCF4 (neutrophil cytosolic factor 4)	protein interactions	4689	12	1	19454	49	PRKCD
2.982e-02	-3.51	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	49	APOE
2.982e-02	-3.51	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	49	PTPN6
2.982e-02	-3.51	ADGRB3 (adhesion G protein-coupled receptor B3)	protein interactions	577	12	1	19454	49	ELMO1
2.982e-02	-3.51	FBXO8 (F-box protein 8)	protein interactions	26269	12	1	19454	49	HIF1A
2.982e-02	-3.51	Cep350 (centrosomal protein 350)	protein interactions	74081	12	1	19454	49	TLN1
2.982e-02	-3.51	SSTR2 (somatostatin receptor 2)	protein interactions	6752	12	1	19454	49	PTPN6
2.982e-02	-3.51	PNMT (phenylethanolamine N-methyltransferase)	protein interactions	5409	12	1	19454	49	HCK
2.982e-02	-3.51	ROPN1L (rhophilin associated tail protein 1 like)	protein interactions	83853	12	1	19454	49	CD74
2.982e-02	-3.51	TENM4 (teneurin transmembrane protein 4)	protein interactions	26011	12	1	19454	49	DOCK2
3.020e-02	-3.50	PGRMC2 (progesterone receptor membrane component 2)	protein interactions	10424	269	3	19454	49	P2RY6,RHBDF2,CD74
3.023e-02	-3.50	MAPK1 (ERK2) activation	REACTOME pathways	R-HSA-112411	9	1	10285	35	IL6R
3.031e-02	-3.50	SLC39A14 (solute carrier family 39 member 14)	protein interactions	23516	108	2	19454	49	P2RY6,P2RY2
3.034e-02	-3.50	Succinate Signalling	SMPDB pathways	SMP0083294	6	1	1369	7	HIF1A
3.035e-02	-3.49	positive regulation of developmental process	biological process	GO:0051094	1385	8	18204	49	GAB1,SPI1,IL6R,CD74,HIF1A,STAT6,APOE,RGS14
3.043e-02	-3.49	Interferon Signaling	REACTOME pathways	R-HSA-913531	201	3	10285	35	PTPN6,IRF5,PRKCD
3.074e-02	-3.48	vinculin binding	molecular function	GO:0017166	12	1	18094	47	TLN1
3.074e-02	-3.48	non-membrane spanning protein tyrosine phosphatase activity	molecular function	GO:0004726	12	1	18094	47	PTPN6
3.074e-02	-3.48	MAP-kinase scaffold activity	molecular function	GO:0005078	12	1	18094	47	AKAP13
3.079e-02	-3.48	IL-3 Signaling Pathway	WikiPathways	WP286	49	2	5310	30	PTPN6,HCK
3.089e-02	-3.48	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	24	16828	45	WDFY4,CSF1R,TBC1D8,MYO1F,DOCK10,PRKCD,NEK6,HIF1A,VAV3,SPI1,AKAP13,DOCK8,STAT6,HCK,TLN1,SBNO2,DOCK1,DOCK2,PIK3R5,PARVG,GMIP,SKAP1,ARHGAP15,GAB1
3.120e-02	-3.47	positive regulation of T cell activation	biological process	GO:0050870	255	3	18204	49	DOCK8,CD74,PTPN6
3.135e-02	-3.46	TIPRL (TOR signaling pathway regulator)	protein interactions	261726	110	2	19454	49	TLN1,RHBDF2
3.135e-02	-3.46	SLC27A2 (solute carrier family 27 member 2)	protein interactions	11001	110	2	19454	49	P2RY6,GSDME
3.138e-02	-3.46	unsaturated fatty acid metabolic process	biological process	GO:0033559	103	2	18204	49	CD74,TBXAS1
3.141e-02	-3.46	human chr16q23.3	chromosome location	human chr16q23.3	17	1	26134	49	PLCG2
3.141e-02	-3.46	human chr1q31.3	chromosome location	human chr1q31.3	17	1	26134	49	DENND1B
3.145e-02	-3.46	negative regulation of catalytic activity	biological process	GO:0043086	445	4	18204	49	PRKCD,RGS14,GMIP,APOE
3.163e-02	-3.45	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	12	1	16828	45	CSF1R
3.167e-02	-3.45	DUF3585	smart domains	SM01203	8	1	9717	39	EHBP1L1
3.170e-02	-3.45	Fc epsilon RI signaling pathway	KEGG pathways	hsa04664	67	2	7161	30	VAV3,PLCG2
3.170e-02	-3.45	Fc epsilon RI signaling pathway	KEGG pathways	ko04664	67	2	7161	30	PLCG2,VAV3
3.184e-02	-3.45	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	49	APOE
3.184e-02	-3.45	regulation of glomerular mesangial cell proliferation	biological process	GO:0072124	12	1	18204	49	IL6R
3.184e-02	-3.45	response to macrophage colony-stimulating factor	biological process	GO:0036005	12	1	18204	49	CSF1R
3.184e-02	-3.45	inositol phosphate biosynthetic process	biological process	GO:0032958	12	1	18204	49	PLCG2
3.184e-02	-3.45	lymphoid progenitor cell differentiation	biological process	GO:0002320	12	1	18204	49	SPI1
3.184e-02	-3.45	insulin secretion involved in cellular response to glucose stimulus	biological process	GO:0035773	12	1	18204	49	HIF1A
3.184e-02	-3.45	mesenchymal cell apoptotic process	biological process	GO:0097152	12	1	18204	49	HIF1A
3.184e-02	-3.45	positive regulation of dendritic cell cytokine production	biological process	GO:0002732	12	1	18204	49	PLCG2
3.184e-02	-3.45	regulation of chemokine-mediated signaling pathway	biological process	GO:0070099	12	1	18204	49	HIF1A
3.184e-02	-3.45	regulation of glial cell apoptotic process	biological process	GO:0034350	12	1	18204	49	PRKCD
3.184e-02	-3.45	nuclear membrane disassembly	biological process	GO:0051081	12	1	18204	49	NEK6
3.184e-02	-3.45	regulation of prostaglandin biosynthetic process	biological process	GO:0031392	12	1	18204	49	CD74
3.184e-02	-3.45	bone trabecula morphogenesis	biological process	GO:0061430	12	1	18204	49	SBNO2
3.184e-02	-3.45	regulation of inflammatory response to wounding	biological process	GO:0106014	12	1	18204	49	PTPN6
3.189e-02	-3.45	Signaling events mediated by VEGFR1 and VEGFR2	Pathway Interaction DB	vegfr1_2_pathway	63	3	2226	25	PTPN6,GAB1,HIF1A
3.191e-02	-3.44	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	5	18094	47	CSF1R,NEK6,PRKCD,HCK,NRK
3.195e-02	-3.44	regulation of anatomical structure morphogenesis	biological process	GO:0022603	894	6	18204	49	ARHGAP15,HCK,HIF1A,ARHGAP33,GAB1,CSF1R
3.195e-02	-3.44	defense response to symbiont	biological process	GO:0140546	894	6	18204	49	IRF5,CSF1R,PTPN6,PLCG2,CD74,HCK
3.202e-02	-3.44	Rhomboid-like	gene3d domains	1.20.1540.10	10	1	14470	47	RHBDF2
3.204e-02	-3.44	IRF_1	prosite domains	PS00601	9	1	12186	44	IRF5
3.204e-02	-3.44	IRF_2	prosite domains	PS51507	9	1	12186	44	IRF5
3.204e-02	-3.44	BEACH	prosite domains	PS50197	9	1	12186	44	WDFY4
3.224e-02	-3.43	HMOX2 (heme oxygenase 2)	protein interactions	3163	276	3	19454	49	P2RY6,APOE,CD74
3.226e-02	-3.43	FCRL3 (Fc receptor like 3)	protein interactions	115352	13	1	19454	49	PTPN6
3.226e-02	-3.43	C1orf74 (chromosome 1 open reading frame 74)	protein interactions	148304	13	1	19454	49	HCK
3.226e-02	-3.43	IL6 (interleukin 6)	protein interactions	3569	13	1	19454	49	IL6R
3.226e-02	-3.43	KCNQ4 (potassium voltage-gated channel subfamily Q member 4)	protein interactions	9132	13	1	19454	49	CSF1R
3.226e-02	-3.43	RTL10 (retrotransposon Gag like 10)	protein interactions	79680	13	1	19454	49	PLCG2
3.226e-02	-3.43	EEIG1 (estrogen-induced osteoclastogenesis regulator 1)	protein interactions	399665	13	1	19454	49	SKAP1
3.226e-02	-3.43	MYBPC3 (myosin binding protein C3)	protein interactions	4607	13	1	19454	49	BLNK
3.226e-02	-3.43	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	49	APOE
3.226e-02	-3.43	GABPB2 (GA binding protein transcription factor subunit beta 2)	protein interactions	126626	13	1	19454	49	PLCG2
3.241e-02	-3.43	UBE2V1 (ubiquitin conjugating enzyme E2 V1)	protein interactions	7335	112	2	19454	49	RHBDF2,P2RY6
3.251e-02	-3.43	positive regulation of myeloid cell differentiation	biological process	GO:0045639	105	2	18204	49	HIF1A,CD74
3.251e-02	-3.43	gland morphogenesis	biological process	GO:0022612	105	2	18204	49	STAT6,CSF1R
3.251e-02	-3.43	biomineral tissue development	biological process	GO:0031214	105	2	18204	49	HIF1A,SBNO2
3.251e-02	-3.43	cellular response to alcohol	biological process	GO:0097306	105	2	18204	49	ADCY7,P2RY6
3.251e-02	-3.43	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	49	ARHGAP33,APOE
3.251e-02	-3.43	antigen processing and presentation	biological process	GO:0019882	105	2	18204	49	CD74,WDFY4
3.251e-02	-3.43	response to type II interferon	biological process	GO:0034341	105	2	18204	49	CD74,HCK
3.256e-02	-3.42	dDENN	pfam domains	PF03455	12	1	17795	49	DENND1B
3.275e-02	-3.42	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	49	TBC1D8,PRKCD,PREX1,ARHGAP33,APOE
3.284e-02	-3.42	chylomicron	cellular component	GO:0042627	13	1	19108	49	APOE
3.294e-02	-3.41	LAT (linker for activation of T cells)	protein interactions	27040	113	2	19454	49	PLCG2,PTPN6
3.294e-02	-3.41	CTAG1B (cancer/testis antigen 1B)	protein interactions	1485	113	2	19454	49	HCK,GMIP
3.301e-02	-3.41	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	17	16828	45	GMIP,ELMO1,SPI1,AKAP13,IRF5,HIF1A,VAV3,EHBP1L1,P2RY2,DOCK8,STAT6,DOCK2,ADCY7,CD74,PIK3R5,DOCK10,PREX1
3.309e-02	-3.41	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	45	CSF1R,HCK,NEK6,PRKCD
3.315e-02	-3.41	Hepatitis C and Hepatocellular Carcinoma	WikiPathways	WP3646	51	2	5310	30	HIF1A,IL6R
3.326e-02	-3.40	insulin receptor substrate binding	molecular function	GO:0043560	13	1	18094	47	PRKCD
3.332e-02	-3.40	tube development	biological process	GO:0035295	903	6	18204	49	HIF1A,CSF1R,GAB1,VAV3,PTPN6,APOE
3.334e-02	-3.40	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	6	19454	49	AKAP13,PRKCD,GAB1,CD74,P2RY6,DENND1B
3.340e-02	-3.40	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	8	16828	45	GMIP,TBC1D8,AKAP13,DOCK2,EHBP1L1,DOCK1,P2RY6,DOCK10
3.340e-02	-3.40	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	8	16828	45	AKAP13,DOCK2,GMIP,TBC1D8,DOCK1,P2RY6,EHBP1L1,DOCK10
3.341e-02	-3.40	response to alcohol	biological process	GO:0097305	262	3	18204	49	TBXAS1,ADCY7,P2RY6
3.349e-02	-3.40	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	9	18204	49	NEK6,CSF1R,PRKCD,HCK,ADCY7,PIK3R5,PTPN6,PLCG2,NRK
3.353e-02	-3.40	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	35	GAB1
3.353e-02	-3.40	MAPK3 (ERK1) activation	REACTOME pathways	R-HSA-110056	10	1	10285	35	IL6R
3.353e-02	-3.40	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	35	ADCY7
3.353e-02	-3.40	MET receptor recycling	REACTOME pathways	R-HSA-8875656	10	1	10285	35	GAB1
3.355e-02	-3.39	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	45	PRKCD,HCK,CSF1R,NEK6
3.367e-02	-3.39	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	2	10285	35	ADCY7,PRKCD
3.369e-02	-3.39	PRKACA (protein kinase cAMP-activated catalytic subunit alpha)	protein interactions	5566	486	4	19454	49	AKAP13,DOCK1,HIF1A,RGS14
3.385e-02	-3.39	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	22	16828	45	DOCK8,STAT6,TLN1,SBNO2,EHBP1L1,DOCK1,VAV3,AKAP13,DOCK10,APOE,PLCG2,WDFY4,CSF1R,TBC1D8,SKAP1,ARHGAP15,GAB1,BLNK,ELMO1,PARVG,PTPN6,DOCK2
3.404e-02	-3.38	KRT34 (keratin 34)	protein interactions	3885	282	3	19454	49	HCK,DOCK2,NEK6
3.405e-02	-3.38	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	4	10285	35	TLN1,ADCY7,GAB1,PRKCD
3.434e-02	-3.37	PRDX3 (peroxiredoxin 3)	protein interactions	10935	283	3	19454	49	DOCK8,APOE,NEK6
3.439e-02	-3.37	regulation of protein secretion	biological process	GO:0050708	265	3	18204	49	APOE,RHBDF2,HIF1A
3.443e-02	-3.37	positive regulation of cell development	biological process	GO:0010720	458	4	18204	49	CD74,HIF1A,SPI1,RGS14
3.444e-02	-3.37	regulation of ceramide biosynthetic process	biological process	GO:2000303	13	1	18204	49	PRKCD
3.444e-02	-3.37	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	49	PRKCD
3.444e-02	-3.37	regulation of sphingolipid biosynthetic process	biological process	GO:0090153	13	1	18204	49	PRKCD
3.444e-02	-3.37	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	biological process	GO:1903377	13	1	18204	49	HIF1A
3.444e-02	-3.37	positive regulation of membrane invagination	biological process	GO:1905155	13	1	18204	49	PLCG2
3.444e-02	-3.37	positive regulation of inositol phosphate biosynthetic process	biological process	GO:0060732	13	1	18204	49	P2RY6
3.444e-02	-3.37	positive regulation of mitophagy	biological process	GO:1901526	13	1	18204	49	HIF1A
3.444e-02	-3.37	response to peptidoglycan	biological process	GO:0032494	13	1	18204	49	IRF5
3.444e-02	-3.37	regulation of thymocyte apoptotic process	biological process	GO:0070243	13	1	18204	49	HIF1A
3.444e-02	-3.37	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	1	18204	49	APOE
3.444e-02	-3.37	membrane disassembly	biological process	GO:0030397	13	1	18204	49	NEK6
3.444e-02	-3.37	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	49	APOE
3.444e-02	-3.37	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	49	IL6R
3.444e-02	-3.37	phospholipid efflux	biological process	GO:0033700	13	1	18204	49	APOE
3.444e-02	-3.37	positive regulation of nitric-oxide synthase activity	biological process	GO:0051000	13	1	18204	49	HIF1A
3.444e-02	-3.37	negative regulation of leukocyte degranulation	biological process	GO:0043301	13	1	18204	49	SPI1
3.444e-02	-3.37	positive regulation of phagocytosis, engulfment	biological process	GO:0060100	13	1	18204	49	PLCG2
3.444e-02	-3.37	defense response to tumor cell	biological process	GO:0002357	13	1	18204	49	SPI1
3.444e-02	-3.37	type II interferon-mediated signaling pathway	biological process	GO:0060333	13	1	18204	49	HCK
3.444e-02	-3.37	regulation of T-helper 2 cell cytokine production	biological process	GO:2000551	13	1	18204	49	DENND1B
3.456e-02	-3.36	LPA receptor mediated events	Pathway Interaction DB	lysophospholipid_pathway	65	3	2226	25	PRKCD,ADCY7,GAB1
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	HCK,SKAP1
3.470e-02	-3.36	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	49	PRKCD
3.470e-02	-3.36	Fez2 (fasciculation and elongation protein zeta 2)	protein interactions	225020	14	1	19454	49	DENND1B
3.470e-02	-3.36	C9 (complement C9)	protein interactions	735	14	1	19454	49	APOE
3.470e-02	-3.36	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	49	APOE
3.470e-02	-3.36	AZIN2 (antizyme inhibitor 2)	protein interactions	113451	14	1	19454	49	TLN1
3.470e-02	-3.36	RHBDF1 (rhomboid 5 homolog 1)	protein interactions	64285	14	1	19454	49	HIF1A
3.470e-02	-3.36	CSF3 (colony stimulating factor 3)	protein interactions	1440	14	1	19454	49	PARVG
3.470e-02	-3.36	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	49	P2RY6
3.481e-02	-3.36	postsynapse organization	biological process	GO:0099173	109	2	18204	49	DOCK10,APOE
3.485e-02	-3.36	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	17	16828	45	SKAP1,ARHGAP15,DOCK1,GAB1,STAT6,HCK,ELMO1,AKAP13,BLNK,HIF1A,VAV3,PLCG2,CD74,DENND1B,DOCK10,DOCK2,WDFY4
3.489e-02	-3.36	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	15	16828	45	ADCY7,DOCK2,WDFY4,GIT2,CSF1R,PLCG2,PRKCD,P2RY6,DOCK10,MYO1F,AKAP13,HIF1A,ARHGAP15,ARHGAP33,TLN1
3.490e-02	-3.36	negative regulation of transport	biological process	GO:0051051	460	4	18204	49	APOE,RHBDF2,CD74,SPI1
3.494e-02	-3.35	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	45	PRKCD,CSF1R,HCK,NEK6
3.504e-02	-3.35	human chr15q25.3	chromosome location	human chr15q25.3	19	1	26134	49	AKAP13
3.506e-02	-3.35	negative regulation of apoptotic process	biological process	GO:0043066	914	6	18204	49	DOCK8,PRKCD,CD74,HCK,HIF1A,CSF1R
3.510e-02	-3.35	ETS1 (ETS proto-oncogene 1, transcription factor)	protein interactions	2113	117	2	19454	49	STAT6,SPI1
3.512e-02	-3.35	DNA-binding transcription activator activity	molecular function	GO:0001216	478	4	18094	47	STAT6,HIF1A,SPI1,IRF5
3.521e-02	-3.35	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	15	16828	45	GMIP,AKAP13,VAV3,ARHGAP33,DOCK1,P2RY2,DOCK8,STAT6,HCK,TBC1D8,WDFY4,GIT2,PARVG,CD74,DOCK10
3.521e-02	-3.35	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	15	16828	45	AKAP13,GMIP,VAV3,DOCK1,ARHGAP33,HCK,STAT6,DOCK8,P2RY2,TBC1D8,GIT2,WDFY4,PARVG,CD74,DOCK10
3.522e-02	-3.35	response to organonitrogen compound	biological process	GO:0010243	915	6	18204	49	P2RY6,PRKCD,P2RY2,STAT6,IRF5,GAB1
3.523e-02	-3.35	SM22CALPONIN	prints domains	PR00888	11	1	5227	17	VAV3
3.537e-02	-3.34	protein localization to membrane	biological process	GO:0072657	462	4	18204	49	SKAP1,APOE,FYB1,RHBDF2
3.539e-02	-3.34	phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	GO:0007200	110	2	18204	49	P2RY6,P2RY2
3.556e-02	-3.34	IRF	smart domains	SM00348	9	1	9717	39	IRF5
3.556e-02	-3.34	Beach	smart domains	SM01026	9	1	9717	39	WDFY4
3.558e-02	-3.34	PSMD13 (proteasome 26S subunit, non-ATPase 13)	protein interactions	5719	287	3	19454	49	PTPN6,PREX1,P2RY6
3.577e-02	-3.33	oxygen carrier activity	molecular function	GO:0005344	14	1	18094	47	IPCEF1
3.593e-02	-3.33	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	49	ARHGAP33,PREX1,APOE,PRKCD,TBC1D8
3.594e-02	-3.33	BCR signaling pathway	Pathway Interaction DB	bcr_5pathway	66	3	2226	25	PTPN6,PLCG2,BLNK
3.598e-02	-3.32	positive regulation of lipid localization	biological process	GO:1905954	111	2	18204	49	PRKCD,APOE
3.609e-02	-3.32	myelodysplastic-myeloproliferative_neoplasm-unclassifiable	COSMIC cancer mutations	myelodysplastic-myeloproliferative_neoplasm-unclassifiable	112	2	16828	45	SPI1,CSF1R
3.609e-02	-3.32	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic-myeloproliferative_neoplasm-unclassifiable	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic-myeloproliferative_neoplasm-unclassifiable	112	2	16828	45	SPI1,CSF1R
3.620e-02	-3.32	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	49	APOE,CD74
3.630e-02	-3.32	positive regulation of metabolic process	biological process	GO:0009893	3796	16	18204	49	PLCG2,IRF5,APOE,SBNO2,STAT6,DENND1B,CSF1R,BLNK,PIK3R5,SPI1,SKAP1,P2RY6,PRKCD,HIF1A,CD74,IL6R
3.631e-02	-3.32	tube morphogenesis	biological process	GO:0035239	685	5	18204	49	VAV3,GAB1,APOE,CSF1R,HIF1A
3.642e-02	-3.31	Rhomboid-like_sf	interpro domains	IPR035952	14	1	18521	49	RHBDF2
3.645e-02	-3.31	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	4	10285	35	VAV3,GAB1,PLCG2,TLN1
3.647e-02	-3.31	phosphorus metabolic process	biological process	GO:0006793	1707	9	18204	49	CSF1R,NEK6,HCK,PRKCD,PIK3R5,ADCY7,NRK,PLCG2,PTPN6
3.648e-02	-3.31	protein-containing complex binding	molecular function	GO:0044877	1772	9	18094	47	SPI1,FYB1,CD74,SBNO2,MYO1F,DOCK2,PIK3R5,APOE,TLN1
3.657e-02	-3.31	extrinsic apoptotic signaling pathway	biological process	GO:0097191	112	2	18204	49	IL6R,SPI1
3.657e-02	-3.31	mononuclear cell migration	biological process	GO:0071674	112	2	18204	49	IL6R,DOCK8
3.664e-02	-3.31	positive regulation of macromolecule metabolic process	biological process	GO:0010604	3485	15	18204	49	IRF5,APOE,PLCG2,CSF1R,SBNO2,STAT6,DENND1B,BLNK,PIK3R5,SKAP1,SPI1,PRKCD,HIF1A,IL6R,CD74
3.676e-02	-3.30	ELP3 (elongator acetyltransferase complex subunit 3)	protein interactions	55140	120	2	19454	49	HIF1A,SKAP1
3.682e-02	-3.30	Signaling by FGFR4 in disease	REACTOME pathways	R-HSA-5655291	11	1	10285	35	GAB1
3.682e-02	-3.30	MET activates RAP1 and RAC1	REACTOME pathways	R-HSA-8875555	11	1	10285	35	GAB1
3.682e-02	-3.30	Interleukin-6 signaling	REACTOME pathways	R-HSA-1059683	11	1	10285	35	IL6R
3.682e-02	-3.30	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	30	PIK3R5,GAB1
3.682e-02	-3.30	Apoptosis-related network due to altered Notch3 in ovarian cancer	WikiPathways	WP2864	54	2	5310	30	APOE,VAV3
3.683e-02	-3.30	GOPC (golgi associated PDZ and coiled-coil motif containing)	protein interactions	57120	291	3	19454	49	CSF1R,HCK,RHBDF2
3.690e-02	-3.30	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	26	16828	45	DOCK10,MYO1F,PLCG2,PRKCD,WDFY4,GIT2,CSF1R,RHBDF2,DOCK8,STAT6,SBNO2,DOCK1,VAV3,HIF1A,AKAP13,PIK3R5,PREX1,TBXAS1,ADCY7,DOCK2,ARHGAP15,SKAP1,GAB1,BLNK,IPCEF1,ELMO1
3.704e-02	-3.30	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	49	APOE
3.704e-02	-3.30	mammary gland epithelial cell proliferation	biological process	GO:0033598	14	1	18204	49	STAT6
3.704e-02	-3.30	positive regulation by symbiont of entry into host	biological process	GO:0075294	14	1	18204	49	CD74
3.704e-02	-3.30	regulation of podosome assembly	biological process	GO:0071801	14	1	18204	49	HCK
3.704e-02	-3.30	T-helper 1 cell differentiation	biological process	GO:0045063	14	1	18204	49	STAT6
3.704e-02	-3.30	regulation of unsaturated fatty acid biosynthetic process	biological process	GO:2001279	14	1	18204	49	CD74
3.704e-02	-3.30	positive regulation of phospholipid metabolic process	biological process	GO:1903727	14	1	18204	49	PRKCD
3.704e-02	-3.30	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	49	APOE
3.704e-02	-3.30	inflammatory response to wounding	biological process	GO:0090594	14	1	18204	49	HIF1A
3.704e-02	-3.30	positive regulation of viral entry into host cell	biological process	GO:0046598	14	1	18204	49	CD74
3.704e-02	-3.30	regulation of mesenchymal cell apoptotic process	biological process	GO:2001053	14	1	18204	49	HIF1A
3.704e-02	-3.30	positive regulation of heterotypic cell-cell adhesion	biological process	GO:0034116	14	1	18204	49	SKAP1
3.704e-02	-3.30	cellular response to lithium ion	biological process	GO:0071285	14	1	18204	49	ADCY7
3.704e-02	-3.30	cellular response to ethanol	biological process	GO:0071361	14	1	18204	49	ADCY7
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	P2RY6
3.704e-02	-3.30	alpha-beta T cell proliferation	biological process	GO:0046633	14	1	18204	49	DOCK2
3.706e-02	-3.30	vascular process in circulatory system	biological process	GO:0003018	273	3	18204	49	P2RY2,TBXAS1,APOE
3.714e-02	-3.29	NBEAL1 (neurobeachin like 1)	protein interactions	65065	15	1	19454	49	HIF1A
3.714e-02	-3.29	IRF6 (interferon regulatory factor 6)	protein interactions	3664	15	1	19454	49	IRF5
3.714e-02	-3.29	AANAT (aralkylamine N-acetyltransferase)	protein interactions	15	15	1	19454	49	P2RY6
3.714e-02	-3.29	GCK (glucokinase)	protein interactions	2645	15	1	19454	49	GMIP
3.714e-02	-3.29	MEP1B (meprin A subunit beta)	protein interactions	4225	15	1	19454	49	PRKCD
3.714e-02	-3.29	EBI3 (Epstein-Barr virus induced 3)	protein interactions	10148	15	1	19454	49	PRKCD
3.714e-02	-3.29	ADRA2A (adrenoceptor alpha 2A)	protein interactions	150	15	1	19454	49	PRKCD
3.715e-02	-3.29	NFKB1 (nuclear factor kappa B subunit 1)	protein interactions	4790	292	3	19454	49	SPI1,STAT6,RGS14
3.715e-02	-3.29	KRTAP10-7 (keratin associated protein 10-7)	protein interactions	386675	292	3	19454	49	DOCK2,HCK,P2RY6
3.717e-02	-3.29	negative regulation of intrinsic apoptotic signaling pathway	biological process	GO:2001243	113	2	18204	49	HIF1A,CD74
3.732e-02	-3.29	EIF3J (eukaryotic translation initiation factor 3 subunit J)	protein interactions	8669	121	2	19454	49	CD74,P2RY6
3.732e-02	-3.29	POLR3B (RNA polymerase III subunit B)	protein interactions	55703	121	2	19454	49	SKAP1,CD74
3.777e-02	-3.28	icosanoid metabolic process	biological process	GO:0006690	114	2	18204	49	CD74,TBXAS1
3.780e-02	-3.28	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	49	APOE
3.784e-02	-3.27	parathyroid	COSMIC cancer mutations	parathyroid	476	4	16828	45	PLCG2,PRKCD,TBC1D8,DOCK2
3.788e-02	-3.27	ELK1 (ETS transcription factor ELK1)	protein interactions	2002	122	2	19454	49	HIF1A,PLCG2
3.808e-02	-3.27	IL-4 Signaling Pathway	WikiPathways	WP395	55	2	5310	30	STAT6,PTPN6
3.808e-02	-3.27	learning or memory	biological process	GO:0007611	276	3	18204	49	APOE,RGS14,HIF1A
3.819e-02	-3.27	membrane raft	cellular component	GO:0045121	290	3	19108	49	SKAP1,PLCG2,HCK
3.828e-02	-3.26	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	47	GSDME
3.828e-02	-3.26	1-phosphatidylinositol-3-kinase regulator activity	molecular function	GO:0046935	15	1	18094	47	PIK3R5
3.830e-02	-3.26	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	47	TLN1
3.837e-02	-3.26	fatty acid biosynthetic process	biological process	GO:0006633	115	2	18204	49	TBXAS1,CD74
3.843e-02	-3.26	RHOU (ras homolog family member U)	protein interactions	58480	507	4	19454	49	GAB1,TBC1D8,EHBP1L1,GIT2
3.844e-02	-3.26	HHV8GK18_gp81 (ORF73)	protein interactions	4961527	123	2	19454	49	HIF1A,RGS14
3.844e-02	-3.26	EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)	protein interactions	8891	123	2	19454	49	P2RY6,CD74
3.866e-02	-3.25	human chr10q26.2	chromosome location	human chr10q26.2	21	1	26134	49	DOCK1
3.878e-02	-3.25	actin filament organization	biological process	GO:0007015	278	3	18204	49	MYO1F,ELMO1,PREX1
3.885e-02	-3.25	membrane microdomain	cellular component	GO:0098857	292	3	19108	49	SKAP1,HCK,PLCG2
3.897e-02	-3.24	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	1	18521	49	PLCG2
3.897e-02	-3.24	SMAD-like_dom_sf	interpro domains	IPR017855	15	1	18521	49	IRF5
3.897e-02	-3.24	CNH_dom	interpro domains	IPR001180	15	1	18521	49	NRK
3.897e-02	-3.24	PI-PLC_fam	interpro domains	IPR001192	15	1	18521	49	PLCG2
3.898e-02	-3.24	cytoskeleton	cellular component	GO:0005856	2412	11	19108	49	TLN1,AKAP13,ARHGAP33,PARVG,DOCK2,HCK,MYO1F,NEK6,PIK3R5,RGS14,FYB1
3.901e-02	-3.24	TNK2 (tyrosine kinase non receptor 2)	protein interactions	10188	124	2	19454	49	NEK6,HCK
3.901e-02	-3.24	CEBPB (CCAAT enhancer binding protein beta)	protein interactions	1051	124	2	19454	49	SPI1,STAT6
3.901e-02	-3.24	CEBPA (CCAAT enhancer binding protein alpha)	protein interactions	1050	124	2	19454	49	SPI1,HIF1A
3.901e-02	-3.24	RNF5 (ring finger protein 5)	protein interactions	6048	124	2	19454	49	HIF1A,P2RY2
3.901e-02	-3.24	TM9SF3 (transmembrane 9 superfamily member 3)	protein interactions	56889	124	2	19454	49	P2RY6,P2RY2
3.936e-02	-3.24	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	gene3d domains	1.10.10.10	232	3	14470	47	SPI1,PREX1,IRF5
3.941e-02	-3.23	TYRKINASE	prints domains	PR00109	98	2	5227	17	HCK,NEK6
3.956e-02	-3.23	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	49	APOE
3.956e-02	-3.23	TAMALIN (trafficking regulator and scaffold protein tamalin)	protein interactions	160622	16	1	19454	49	DOCK1
3.956e-02	-3.23	KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)	protein interactions	3761	16	1	19454	49	PRKCD
3.956e-02	-3.23	TNFRSF25 (TNF receptor superfamily member 25)	protein interactions	8718	16	1	19454	49	PTPN6
3.956e-02	-3.23	EPO (erythropoietin)	protein interactions	2056	16	1	19454	49	HIF1A
3.956e-02	-3.23	PRICKLE4 (prickle planar cell polarity protein 4)	protein interactions	29964	16	1	19454	49	NEK6
3.956e-02	-3.23	IL1RL2 (interleukin 1 receptor like 2)	protein interactions	8808	16	1	19454	49	MYO1F
3.956e-02	-3.23	ZSCAN4 (zinc finger and SCAN domain containing 4)	protein interactions	201516	16	1	19454	49	HCK
3.956e-02	-3.23	RASGRP3 (RAS guanyl releasing protein 3)	protein interactions	25780	16	1	19454	49	PRKCD
3.956e-02	-3.23	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	49	PLCG2
3.959e-02	-3.23	cellular detoxification	biological process	GO:1990748	117	2	18204	49	APOE,IPCEF1
3.964e-02	-3.23	positive regulation of hormone metabolic process	biological process	GO:0032352	15	1	18204	49	HIF1A
3.964e-02	-3.23	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	49	APOE
3.964e-02	-3.23	negative regulation of B cell mediated immunity	biological process	GO:0002713	15	1	18204	49	PTPN6
3.964e-02	-3.23	negative regulation of type 2 immune response	biological process	GO:0002829	15	1	18204	49	STAT6
3.964e-02	-3.23	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902166	15	1	18204	49	CD74
3.964e-02	-3.23	regulation of phagocytosis, engulfment	biological process	GO:0060099	15	1	18204	49	PLCG2
3.964e-02	-3.23	negative regulation of B cell apoptotic process	biological process	GO:0002903	15	1	18204	49	CD74
3.964e-02	-3.23	negative regulation of DNA damage response, signal transduction by p53 class mediator	biological process	GO:0043518	15	1	18204	49	CD74
3.964e-02	-3.23	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	49	APOE
3.964e-02	-3.23	oxygen transport	biological process	GO:0015671	15	1	18204	49	IPCEF1
3.964e-02	-3.23	columnar/cuboidal epithelial cell maturation	biological process	GO:0002069	15	1	18204	49	HIF1A
3.964e-02	-3.23	negative regulation of immunoglobulin mediated immune response	biological process	GO:0002890	15	1	18204	49	PTPN6
3.964e-02	-3.23	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	1	18204	49	P2RY6
3.964e-02	-3.23	regulation of membrane invagination	biological process	GO:1905153	15	1	18204	49	PLCG2
3.975e-02	-3.23	PPM1G (protein phosphatase, Mg2+/Mn2+ dependent 1G)	protein interactions	5496	300	3	19454	49	P2RY6,STAT6,IRF5
4.008e-02	-3.22	ARRB1 (arrestin beta 1)	protein interactions	408	301	3	19454	49	HIF1A,HCK,NEK6
4.009e-02	-3.22	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	4	16828	45	WDFY4,DOCK8,ELMO1,IPCEF1
4.009e-02	-3.22	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	4	16828	45	WDFY4,DOCK8,ELMO1,IPCEF1
4.010e-02	-3.22	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	35	HIF1A
4.010e-02	-3.22	PECAM1 interactions	REACTOME pathways	R-HSA-210990	12	1	10285	35	PTPN6
4.010e-02	-3.22	Eicosanoids	REACTOME pathways	R-HSA-211979	12	1	10285	35	TBXAS1
4.020e-02	-3.21	biological process involved in interaction with symbiont	biological process	GO:0051702	118	2	18204	49	CSF1R,APOE
4.041e-02	-3.21	TRAF1 (TNF receptor associated factor 1)	protein interactions	7185	302	3	19454	49	GIT2,VAV3,TBC1D8
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	NRK
4.053e-02	-3.21	PI-PLC-Y	pfam domains	PF00387	15	1	17795	49	PLCG2
4.061e-02	-3.20	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	4	16828	45	CSF1R,HCK,NEK6,PRKCD
4.074e-02	-3.20	PPIB (peptidylprolyl isomerase B)	protein interactions	5479	303	3	19454	49	PREX1,IRF5,DOCK8
4.076e-02	-3.20	TyrKc	smart domains	SM00219	80	2	9717	39	CSF1R,HCK
4.078e-02	-3.20	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	47	ADCY7
4.078e-02	-3.20	diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004697	16	1	18094	47	PRKCD
4.082e-02	-3.20	negative regulation of protein transport	biological process	GO:0051224	119	2	18204	49	APOE,RHBDF2
4.086e-02	-3.20	VEGFR1 specific signals	Pathway Interaction DB	vegfr1_pathway	29	2	2226	25	GAB1,HIF1A
4.108e-02	-3.19	SH3KBP1 (SH3 domain containing kinase binding protein 1)	protein interactions	30011	304	3	19454	49	ARHGAP27,BLNK,HCK
4.123e-02	-3.19	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	4	10285	35	PRKCD,GAB1,TLN1,ADCY7
4.126e-02	-3.19	cellular response to chemical stress	biological process	GO:0062197	285	3	18204	49	PRKCD,HIF1A,STAT6
4.132e-02	-3.19	TACSTD2 (tumor associated calcium signal transducer 2)	protein interactions	4070	128	2	19454	49	GSDME,TBC1D8
4.143e-02	-3.18	-	gene3d domains	3.30.450.200	13	1	14470	47	DENND1B
4.152e-02	-3.18	dDENN_dom	interpro domains	IPR005112	16	1	18521	49	DENND1B
4.152e-02	-3.18	DENN_C	interpro domains	IPR043153	16	1	18521	49	DENND1B
4.152e-02	-3.18	uDENN_dom	interpro domains	IPR005113	16	1	18521	49	DENND1B
4.173e-02	-3.18	cytoskeletal protein binding	molecular function	GO:0008092	989	6	18094	47	RGS14,APOE,TLN1,NEK6,PARVG,MYO1F
4.182e-02	-3.17	protein tyrosine kinase binding	molecular function	GO:1990782	125	2	18094	47	PLCG2,BLNK
4.188e-02	-3.17	kinase activity	molecular function	GO:0016301	739	5	18094	47	PRKCD,CSF1R,NEK6,HCK,NRK
4.190e-02	-3.17	EIF2B4 (eukaryotic translation initiation factor 2B subunit delta)	protein interactions	8890	129	2	19454	49	P2RY6,CD74
4.190e-02	-3.17	PLD1 (phospholipase D1)	protein interactions	5337	129	2	19454	49	PLCG2,HIF1A
4.190e-02	-3.17	non_seminoma	COSMIC cancer mutations	non_seminoma	492	4	16828	45	PRKCD,HCK,CSF1R,NEK6
4.196e-02	-3.17	normal	COSMIC cancer mutations	normal	16	1	16828	45	CSF1R
4.198e-02	-3.17	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	49	APOE
4.198e-02	-3.17	SAT2 (spermidine/spermine N1-acetyltransferase family member 2)	protein interactions	112483	17	1	19454	49	HIF1A
4.198e-02	-3.17	RIMBP3C (RIMS binding protein 3C)	protein interactions	150221	17	1	19454	49	NEK6
4.198e-02	-3.17	FAM131C (family with sequence similarity 131 member C)	protein interactions	348487	17	1	19454	49	RHBDF2
4.198e-02	-3.17	SLAMF6 (SLAM family member 6)	protein interactions	114836	17	1	19454	49	PTPN6
4.198e-02	-3.17	CITED2 (Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2)	protein interactions	10370	17	1	19454	49	HIF1A
4.207e-02	-3.17	negative regulation of immune effector process	biological process	GO:0002698	121	2	18204	49	PTPN6,SPI1
4.207e-02	-3.17	centriolar satellite	cellular component	GO:0034451	127	2	19108	49	NEK6,PIK3R5
4.223e-02	-3.16	response to lithium ion	biological process	GO:0010226	16	1	18204	49	ADCY7
4.223e-02	-3.16	lactate metabolic process	biological process	GO:0006089	16	1	18204	49	HIF1A
4.223e-02	-3.16	positive regulation of autophagy of mitochondrion	biological process	GO:1903599	16	1	18204	49	HIF1A
4.223e-02	-3.16	regulation of cell proliferation involved in kidney development	biological process	GO:1901722	16	1	18204	49	IL6R
4.223e-02	-3.16	asymmetric cell division	biological process	GO:0008356	16	1	18204	49	RGS14
4.223e-02	-3.16	regulation of adipose tissue development	biological process	GO:1904177	16	1	18204	49	SPI1
4.223e-02	-3.16	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	49	APOE
4.223e-02	-3.16	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	49	APOE
4.223e-02	-3.16	intestinal epithelial cell development	biological process	GO:0060576	16	1	18204	49	HIF1A
4.223e-02	-3.16	positive regulation of immune response to tumor cell	biological process	GO:0002839	16	1	18204	49	GSDME
4.223e-02	-3.16	positive regulation of B cell differentiation	biological process	GO:0045579	16	1	18204	49	SPI1
4.223e-02	-3.16	positive regulation of response to tumor cell	biological process	GO:0002836	16	1	18204	49	GSDME
4.223e-02	-3.16	cellular response to prostaglandin E stimulus	biological process	GO:0071380	16	1	18204	49	P2RY6
4.223e-02	-3.16	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	49	APOE
4.234e-02	-3.16	positive regulation of innate immune response	biological process	GO:0045089	288	3	18204	49	SPI1,PLCG2,HCK
4.249e-02	-3.16	YIPF5 (Yip1 domain family member 5)	protein interactions	81555	130	2	19454	49	P2RY6,P2RY2
4.266e-02	-3.15	D-myo-inositol (1,4,5)-trisphosphate biosynthesis	BIOCYC pathways	META_PWY-6351	13	1	902	3	PLCG2
4.271e-02	-3.15	muscle cell differentiation	biological process	GO:0042692	289	3	18204	49	DOCK2,DOCK1,AKAP13
4.273e-02	-3.15	MHC class II protein complex	cellular component	GO:0042613	17	1	19108	49	CD74
4.278e-02	-3.15	embryonal	COSMIC cancer mutations	embryonal	2659	12	16828	45	EHBP1L1,APOE,PLCG2,PARVG,DOCK1,PTPN6,DOCK8,DOCK10,ELMO1,AKAP13,WDFY4,VAV3
4.278e-02	-3.15	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	12	16828	45	APOE,PLCG2,EHBP1L1,PTPN6,DOCK1,PARVG,DOCK8,DOCK10,ELMO1,AKAP13,WDFY4,VAV3
4.308e-02	-3.14	LGALS7 (galectin 7)	protein interactions	3963	131	2	19454	49	DOCK8,GAB1
4.308e-02	-3.14	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	49	HIF1A,STAT6
4.318e-02	-3.14	uDENN	pfam domains	PF03456	16	1	17795	49	DENND1B
4.321e-02	-3.14	plasma membrane region	cellular component	GO:0098590	1278	7	19108	49	P2RY6,IL6R,PLCG2,HCK,DOCK8,TLN1,SKAP1
4.327e-02	-3.14	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	47	PTPN6
4.327e-02	-3.14	transmembrane receptor protein tyrosine kinase adaptor activity	molecular function	GO:0005068	17	1	18094	47	BLNK
4.327e-02	-3.14	GDP-dissociation inhibitor activity	molecular function	GO:0005092	17	1	18094	47	RGS14
4.327e-02	-3.14	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	47	PTPN6
4.337e-02	-3.14	FCGR activation	REACTOME pathways	R-HSA-2029481	13	1	10285	35	HCK
4.348e-02	-3.14	Regulation of CDC42 activity	Pathway Interaction DB	cdc42_reg_pathway	30	2	2226	25	DOCK10,VAV3
4.365e-02	-3.13	histone deacetylase binding	molecular function	GO:0042826	128	2	18094	47	SPI1,HIF1A
4.367e-02	-3.13	TXNDC12 (thioredoxin domain containing 12)	protein interactions	51060	132	2	19454	49	TLN1,HCK
4.381e-02	-3.13	ACTN1 (actinin alpha 1)	protein interactions	87	312	3	19454	49	PTPN6,TLN1,GIT2
4.406e-02	-3.12	RGS_subdom1/3	interpro domains	IPR024066	17	1	18521	49	RGS14
4.406e-02	-3.12	Thyroglobulin_1	interpro domains	IPR000716	17	1	18521	49	CD74
4.406e-02	-3.12	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	1	18521	49	PLCG2
4.406e-02	-3.12	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	49	ADCY7
4.406e-02	-3.12	PAC	interpro domains	IPR001610	17	1	18521	49	HIF1A
4.406e-02	-3.12	Thyroglobulin_1_sf	interpro domains	IPR036857	17	1	18521	49	CD74
4.406e-02	-3.12	cDENN_dom	interpro domains	IPR001194	17	1	18521	49	DENND1B
4.440e-02	-3.11	DCAF17 (DDB1 and CUL4 associated factor 17)	protein interactions	80067	18	1	19454	49	PREX1
4.440e-02	-3.11	TM4SF20 (transmembrane 4 L six family member 20)	protein interactions	79853	18	1	19454	49	CD74
4.440e-02	-3.11	BEX4 (brain expressed X-linked 4)	protein interactions	56271	18	1	19454	49	PRKCD
4.440e-02	-3.11	ZKSCAN7 (zinc finger with KRAB and SCAN domains 7)	protein interactions	55888	18	1	19454	49	PLCG2
4.440e-02	-3.11	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	49	APOE
4.440e-02	-3.11	Chmp6 (charged multivesicular body protein 6)	protein interactions	208092	18	1	19454	49	PTPN6
4.440e-02	-3.11	GALM (galactose mutarotase)	protein interactions	130589	18	1	19454	49	AKAP13
4.461e-02	-3.11	regulation of cell-matrix adhesion	biological process	GO:0001952	125	2	18204	49	TLN1,SKAP1
4.461e-02	-3.11	memory	biological process	GO:0007613	125	2	18204	49	RGS14,APOE
4.481e-02	-3.11	reverse cholesterol transport	biological process	GO:0043691	17	1	18204	49	APOE
4.481e-02	-3.11	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	49	APOE
4.481e-02	-3.11	regulation of dendritic cell cytokine production	biological process	GO:0002730	17	1	18204	49	PLCG2
4.481e-02	-3.11	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	49	APOE
4.481e-02	-3.11	monocyte differentiation	biological process	GO:0030224	17	1	18204	49	CSF1R
4.481e-02	-3.11	regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	biological process	GO:1902165	17	1	18204	49	CD74
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	CD74
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	P2RY2
4.481e-02	-3.11	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	49	APOE
4.481e-02	-3.11	regulation of amyloid fibril formation	biological process	GO:1905906	17	1	18204	49	APOE
4.481e-02	-3.11	cellular response to reactive nitrogen species	biological process	GO:1902170	17	1	18204	49	STAT6
4.481e-02	-3.11	axonal transport of mitochondrion	biological process	GO:0019896	17	1	18204	49	HIF1A
4.481e-02	-3.11	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	49	APOE
4.481e-02	-3.11	negative regulation of humoral immune response	biological process	GO:0002921	17	1	18204	49	PTPN6
4.481e-02	-3.11	response to hepatocyte growth factor	biological process	GO:0035728	17	1	18204	49	GAB1
4.481e-02	-3.11	regulation of integrin activation	biological process	GO:0033623	17	1	18204	49	SKAP1
4.481e-02	-3.11	regulation of plasma membrane organization	biological process	GO:1903729	17	1	18204	49	PRKCD
4.481e-02	-3.11	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	49	HIF1A
4.481e-02	-3.11	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	49	IL6R
4.486e-02	-3.10	DARS1 (aspartyl-tRNA synthetase 1)	protein interactions	1615	315	3	19454	49	PTPN6,TLN1,PRKCD
4.503e-02	-3.10	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	10	16828	45	BLNK,RGS14,NEK6,GIT2,CSF1R,PRKCD,DOCK1,P2RY2,STAT6,HCK
4.517e-02	-3.10	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	44	HCK,CSF1R
4.525e-02	-3.10	regulation of type I interferon production	biological process	GO:0032479	126	2	18204	49	PLCG2,IRF5
4.525e-02	-3.10	response to ethanol	biological process	GO:0045471	126	2	18204	49	TBXAS1,ADCY7
4.547e-02	-3.09	JAK3 (Janus kinase 3)	protein interactions	3718	135	2	19454	49	PTPN6,STAT6
4.556e-02	-3.09	HIV Infection	REACTOME pathways	R-HSA-162906	236	3	10285	35	ELMO1,HCK,DOCK2
4.576e-02	-3.08	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	47	APOE
4.581e-02	-3.08	DENN	pfam domains	PF02141	17	1	17795	49	DENND1B
4.581e-02	-3.08	PI-PLC-X	pfam domains	PF00388	17	1	17795	49	PLCG2
4.581e-02	-3.08	Thyroglobulin_1	pfam domains	PF00086	17	1	17795	49	CD74
4.590e-02	-3.08	positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002824	127	2	18204	49	DENND1B,STAT6
4.590e-02	-3.08	cellular response to toxic substance	biological process	GO:0097237	127	2	18204	49	APOE,IPCEF1
4.592e-02	-3.08	TRIM54 (tripartite motif containing 54)	protein interactions	57159	318	3	19454	49	ELMO1,PARVG,NEK6
4.606e-02	-3.08	CLEC7A (Dectin-1) signaling	REACTOME pathways	R-HSA-5607764	101	2	10285	35	PRKCD,PLCG2
4.608e-02	-3.08	PYGB (glycogen phosphorylase B)	protein interactions	5834	136	2	19454	49	PRKCD,FYB1
4.608e-02	-3.08	ITGB5 (integrin subunit beta 5)	protein interactions	3693	136	2	19454	49	P2RY2,TLN1
4.608e-02	-3.08	IRS1 (insulin receptor substrate 1)	protein interactions	3667	136	2	19454	49	PRKCD,PLCG2
4.608e-02	-3.08	ROCK2 (Rho associated coiled-coil containing protein kinase 2)	protein interactions	9475	136	2	19454	49	AKAP13,TLN1
4.616e-02	-3.08	cellular localization	biological process	GO:0051641	2660	12	18204	49	HCK,HIF1A,CD74,DENND1B,SKAP1,ARHGAP33,RGS14,FYB1,APOE,GIT2,RHBDF2,DOCK2
4.616e-02	-3.08	EPHA forward signaling	Pathway Interaction DB	epha_fwdpathway	31	2	2226	25	HCK,VAV3
4.621e-02	-3.07	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	4	16828	45	PRKCD,NEK6,CSF1R,HCK
4.624e-02	-3.07	cellular response to hormone stimulus	biological process	GO:0032870	504	4	18204	49	GAB1,STAT6,P2RY6,PRKCD
4.627e-02	-3.07	GCN1 (GCN1 activator of EIF2AK4)	protein interactions	10985	319	3	19454	49	HIF1A,P2RY6,NEK6
4.630e-02	-3.07	acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_T_cell_leukaemia	739	5	16828	45	CSF1R,PLCG2,PTPN6,DOCK1,DOCK2
4.630e-02	-3.07	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	739	5	16828	45	DOCK1,DOCK2,PTPN6,PLCG2,CSF1R
4.633e-02	-3.07	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	3	16828	45	WDFY4,DOCK2,ARHGAP15
4.641e-02	-3.07	negative regulation of multicellular organismal process	biological process	GO:0051241	1237	7	18204	49	APOE,ADCY7,PTPN6,CD74,HIF1A,PRKCD,SPI1
4.655e-02	-3.07	regulation of protein binding	biological process	GO:0043393	128	2	18204	49	APOE,PRKCD
4.659e-02	-3.07	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	49	ADCY7
4.659e-02	-3.07	A/G_cyclase	interpro domains	IPR001054	18	1	18521	49	ADCY7
4.663e-02	-3.07	Regulation of IFNG signaling	REACTOME pathways	R-HSA-877312	14	1	10285	35	PTPN6
4.663e-02	-3.07	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	35	DOCK1
4.681e-02	-3.06	PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2)	protein interactions	57546	19	1	19454	49	PRKCD
4.681e-02	-3.06	SLITRK3 (SLIT and NTRK like family member 3)	protein interactions	22865	19	1	19454	49	RHBDF2
4.681e-02	-3.06	PEX2 (peroxisomal biogenesis factor 2)	protein interactions	5828	19	1	19454	49	PTPN6
4.681e-02	-3.06	ZNF197 (zinc finger protein 197)	protein interactions	10168	19	1	19454	49	HIF1A
4.681e-02	-3.06	PPRC1 (PPARG related coactivator 1)	protein interactions	23082	19	1	19454	49	PRKCD
4.681e-02	-3.06	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	49	PRKCD
4.681e-02	-3.06	RCVRN (recoverin)	protein interactions	5957	19	1	19454	49	GIT2
4.681e-02	-3.06	CSF1 (colony stimulating factor 1)	protein interactions	1435	19	1	19454	49	CSF1R
4.715e-02	-3.05	intracellular anatomical structure	cellular component	GO:0005622	15205	44	19108	49	ARHGAP27,VAV3,PIK3R5,GIT2,NRK,APOE,CSF1R,DOCK8,BLNK,PTPN6,GAB1,DENND1B,PLCG2,HIF1A,AKAP13,ELMO1,STAT6,DOCK10,PRKCD,CARMIL3,EHBP1L1,HCK,SPI1,MYO1F,GMIP,TBXAS1,WDFY4,IRF5,CD74,RGS14,ARHGAP15,IPCEF1,SBNO2,GSDME,SKAP1,FYB1,RHBDF2,DOCK1,TLN1,PREX1,ARHGAP33,PARVG,DOCK2,NEK6
4.720e-02	-3.05	response to organophosphorus	biological process	GO:0046683	129	2	18204	49	P2RY2,P2RY6
4.720e-02	-3.05	positive regulation of lymphocyte mediated immunity	biological process	GO:0002708	129	2	18204	49	STAT6,DENND1B
4.730e-02	-3.05	Regulation of toll-like receptor signaling pathway	WikiPathways	WP1449	145	3	5310	30	PIK3R5,PTPN6,IRF5
4.730e-02	-3.05	AKAP12 (A-kinase anchoring protein 12)	protein interactions	9590	138	2	19454	49	HCK,RHBDF2
4.730e-02	-3.05	NCOA1 (nuclear receptor coactivator 1)	protein interactions	8648	138	2	19454	49	STAT6,HIF1A
4.735e-02	-3.05	ITGB1 (integrin subunit beta 1)	protein interactions	3688	322	3	19454	49	P2RY6,TLN1,RHBDF2
4.738e-02	-3.05	positive regulation of superoxide anion generation	biological process	GO:0032930	18	1	18204	49	PRKCD
4.738e-02	-3.05	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	49	DOCK10
4.738e-02	-3.05	positive regulation of vascular endothelial growth factor receptor signaling pathway	biological process	GO:0030949	18	1	18204	49	HIF1A
4.738e-02	-3.05	morphogenesis of an epithelial fold	biological process	GO:0060571	18	1	18204	49	HIF1A
4.738e-02	-3.05	cell-cell junction maintenance	biological process	GO:0045217	18	1	18204	49	CSF1R
4.738e-02	-3.05	regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002923	18	1	18204	49	PTPN6
4.738e-02	-3.05	positive regulation of neuroinflammatory response	biological process	GO:0150078	18	1	18204	49	PLCG2
4.738e-02	-3.05	antifungal innate immune response	biological process	GO:0061760	18	1	18204	49	PLCG2
4.765e-02	-3.04	-	gene3d domains	2.60.200.10	15	1	14470	47	IRF5
4.775e-02	-3.04	PHPHLIPASEC	prints domains	PR00390	15	1	5227	17	PLCG2
4.786e-02	-3.04	negative regulation of T cell activation	biological process	GO:0050868	130	2	18204	49	CD74,PTPN6
4.789e-02	-3.04	Ser/Thr_kinase_AS	interpro domains	IPR008271	308	3	18521	49	NEK6,NRK,PRKCD
4.792e-02	-3.04	PTPRA (protein tyrosine phosphatase receptor type A)	protein interactions	5786	139	2	19454	49	PRKCD,GAB1
4.792e-02	-3.04	HOMEZ (homeobox and leucine zipper encoding)	protein interactions	57594	139	2	19454	49	NEK6,PARVG
4.792e-02	-3.04	MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking)	protein interactions	23041	139	2	19454	49	HIF1A,P2RY6
4.812e-02	-3.03	positive regulation of protein metabolic process	biological process	GO:0051247	1247	7	18204	49	IL6R,CD74,PRKCD,CSF1R,PLCG2,APOE,PIK3R5
4.817e-02	-3.03	atypical	COSMIC cancer mutations	atypical	515	4	16828	45	PRKCD,NEK6,HCK,CSF1R
4.835e-02	-3.03	coated vesicle	cellular component	GO:0030135	319	3	19108	49	CD74,DENND1B,APOE
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY7
4.853e-02	-3.03	USP19 (ubiquitin specific peptidase 19)	protein interactions	10869	140	2	19454	49	HIF1A,TLN1
4.880e-02	-3.02	PXN (paxillin)	protein interactions	5829	326	3	19454	49	GIT2,TLN1,HCK
4.884e-02	-3.02	clathrin-coated vesicle membrane	cellular component	GO:0030665	138	2	19108	49	CD74,APOE
4.887e-02	-3.02	ErbB signaling pathway	KEGG pathways	hsa04012	85	2	7161	30	PLCG2,GAB1
4.887e-02	-3.02	ErbB signaling pathway	KEGG pathways	ko04012	85	2	7161	30	GAB1,PLCG2
4.889e-02	-3.02	negative regulation of molecular function	biological process	GO:0044092	744	5	18204	49	APOE,SPI1,RGS14,PRKCD,GMIP
4.891e-02	-3.02	Trk receptor signaling mediated by PI3K and PLC-gamma	Pathway Interaction DB	pi3kplctrkpathway	32	2	2226	25	PRKCD,GAB1
4.891e-02	-3.02	Alpha-synuclein signaling	Pathway Interaction DB	alphasynuclein_pathway	32	2	2226	25	PRKCD,HCK
4.910e-02	-3.01	secretory granule lumen	cellular component	GO:0034774	321	3	19108	49	PRKCD,DOCK2,PTPN6
4.911e-02	-3.01	GRAM	interpro domains	IPR004182	19	1	18521	49	TBC1D8
4.911e-02	-3.01	PAS_fold	interpro domains	IPR013767	19	1	18521	49	HIF1A
4.916e-02	-3.01	PELO (pelota mRNA surveillance and ribosome rescue factor)	protein interactions	53918	141	2	19454	49	P2RY6,HIF1A
4.916e-02	-3.01	ATP5IF1 (ATP synthase inhibitory factor subunit 1)	protein interactions	93974	141	2	19454	49	P2RY6,P2RY2
4.921e-02	-3.01	ATG9B (autophagy related 9B)	protein interactions	285973	20	1	19454	49	TLN1
4.921e-02	-3.01	SPIB (Spi-B transcription factor)	protein interactions	6689	20	1	19454	49	SPI1
4.921e-02	-3.01	SAXO5 (stabilizer of axonemal microtubules 5)	protein interactions	374877	20	1	19454	49	NEK6
4.921e-02	-3.01	H2BC12L (H2B clustered histone 12 like)	protein interactions	54145	20	1	19454	49	PRKCD
4.921e-02	-3.01	IFNG (interferon gamma)	protein interactions	3458	20	1	19454	49	STAT6
4.922e-02	-3.01	skin-axilla-malignant_melanoma	COSMIC cancer mutations	skin-axilla-malignant_melanoma	133	2	16828	45	ELMO1,IPCEF1
4.934e-02	-3.01	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	45	16828	45	DOCK10,PRKCD,APOE,CSF1R,GIT2,WDFY4,TBC1D8,RHBDF2,STAT6,HCK,DOCK1,EHBP1L1,SBNO2,NEK6,HIF1A,IRF5,AKAP13,PIK3R5,PARVG,CD74,ARHGAP27,TBXAS1,DOCK2,ADCY7,P2RY2,ARHGAP15,GMIP,DENND1B,MYO1F,IL6R,P2RY6,PLCG2,TLN1,DOCK8,VAV3,SPI1,PREX1,PTPN6,ARHGAP33,GAB1,SKAP1,BLNK,RGS14,ELMO1,IPCEF1
4.937e-02	-3.01	monoatomic ion homeostasis	biological process	GO:0050801	515	4	18204	49	P2RY2,HIF1A,TBXAS1,APOE
4.943e-02	-3.01	human chr10q11.23	chromosome location	human chr10q11.23	27	1	26134	49	WDFY4
4.943e-02	-3.01	human chr5p13.1	chromosome location	human chr5p13.1	27	1	26134	49	FYB1
4.963e-02	-3.00	skin-chest-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-chest-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	genital	COSMIC cancer mutations	genital	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-back-other-keratoacanthoma	COSMIC cancer mutations	skin-back-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-upper_leg-other-keratoacanthoma	COSMIC cancer mutations	skin-upper_leg-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-genital-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-genital-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-upper_arm-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-upper_arm-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-lip-other-keratoacanthoma	COSMIC cancer mutations	skin-lip-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-lower_leg-other-keratoacanthoma	COSMIC cancer mutations	skin-lower_leg-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-chest-other-keratoacanthoma	COSMIC cancer mutations	skin-chest-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-arm-other-keratoacanthoma	COSMIC cancer mutations	skin-arm-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-face-other-keratoacanthoma	COSMIC cancer mutations	skin-face-other-keratoacanthoma	19	1	16828	45	CSF1R
4.963e-02	-3.00	skin-leg-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-leg-carcinoma-squamous_cell_carcinoma	19	1	16828	45	CSF1R
4.975e-02	-3.00	miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma	WikiPathways	WP3593	9	1	5310	30	HIF1A
4.978e-02	-3.00	SACM1L (SAC1 like phosphatidylinositide phosphatase)	protein interactions	22908	142	2	19454	49	P2RY6,P2RY2
4.983e-02	-3.00	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	49	HCK,CSF1R
4.985e-02	-3.00	positive regulation of endothelial cell migration	biological process	GO:0010595	133	2	18204	49	GAB1,HIF1A
4.988e-02	-3.00	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME pathways	R-HSA-2162123	15	1	10285	35	TBXAS1
4.988e-02	-3.00	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME pathways	R-HSA-399955	15	1	10285	35	TLN1
4.988e-02	-3.00	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	35	ADCY7
4.988e-02	-3.00	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	35	ADCY7
4.994e-02	-3.00	growth factor receptor binding	molecular function	GO:0070851	138	2	18094	47	IL6R,VAV3
4.995e-02	-3.00	regulation of protein neddylation	biological process	GO:2000434	19	1	18204	49	HIF1A
4.995e-02	-3.00	response to hydroperoxide	biological process	GO:0033194	19	1	18204	49	PRKCD
4.995e-02	-3.00	chloride ion homeostasis	biological process	GO:0055064	19	1	18204	49	TBXAS1
4.995e-02	-3.00	positive regulation of macrophage chemotaxis	biological process	GO:0010759	19	1	18204	49	CSF1R
4.995e-02	-3.00	regulation of B cell apoptotic process	biological process	GO:0002902	19	1	18204	49	CD74
4.995e-02	-3.00	adenylate cyclase-activating adrenergic receptor signaling pathway	biological process	GO:0071880	19	1	18204	49	AKAP13
4.995e-02	-3.00	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	49	APOE
4.995e-02	-3.00	positive regulation of reactive oxygen species biosynthetic process	biological process	GO:1903428	19	1	18204	49	PLCG2
4.995e-02	-3.00	regulation of mast cell activation	biological process	GO:0033003	19	1	18204	49	PTPN6
4.995e-02	-3.00	regulation of amyloid-beta clearance	biological process	GO:1900221	19	1	18204	49	APOE