Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.790e-08	-17.84	lymph_node	COSMIC cancer mutations	lymph_node	1703	20	16828	49	DTNA,NRG3,TRPS1,PRKG1,CTNND2,NAV2,DCLK1,LSAMP,SOX5,DPP10,LIFR,PCDH9,ERBB4,CAMK2G,TRPM3,SLC39A11,RYR3,WDR49,RPS6KA2,ARAP2
4.446e-08	-16.93	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	25	16828	49	PPP2R2B,ABR,WDR49,RYR3,SLC39A11,RFX4,DST,ADCY2,ERBB4,LIFR,SLC1A2,SOX5,IQCA1,NAV2,HIF3A,PRKG1,NRG3,TRPM3,PCDH9,LSAMP,HPSE2,DAAM2,FMN2,CTNND2,TRPS1
9.120e-08	-16.21	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	11	16828	49	NRG3,RYR3,PRKG1,WDR49,SLC39A11,CTNND2,NAV2,LSAMP,PCDH9,ERBB4,TRPM3
1.057e-07	-16.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	16	16828	49	ERBB4,ADCY2,CAMK2G,LSAMP,DCLK1,SOX5,SLC1A2,BMPR1B,NPAS3,NAV2,HPSE2,NRG3,PRKG1,DCLK2,RPS6KA2,RYR3
1.057e-07	-16.06	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	16	16828	49	LSAMP,DCLK1,NPAS3,BMPR1B,SLC1A2,SOX5,CAMK2G,ADCY2,ERBB4,NRG3,PRKG1,HPSE2,NAV2,RYR3,DCLK2,RPS6KA2
1.451e-07	-15.75	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	27	16828	49	PITPNC1,MGAT4C,DAAM2,HPSE2,CTNND2,FMN2,BMPR1B,NPAS3,PCDH9,LSAMP,DCLK1,TRPM3,RYR3,PPP2R2B,ABR,MSI2,PRKG1,NRG3,DTNA,NAV2,MACF1,LIFR,IQCA1,DST,TNRC6A,ADCY2,ERBB4
1.451e-07	-15.75	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	27	16828	49	RYR3,PPP2R2B,ABR,MSI2,PRKG1,NRG3,DTNA,MACF1,NAV2,LIFR,IQCA1,DST,ADCY2,ERBB4,TNRC6A,PITPNC1,MGAT4C,HPSE2,DAAM2,FMN2,CTNND2,PCDH9,NPAS3,BMPR1B,DCLK1,LSAMP,TRPM3
2.171e-07	-15.34	central nervous system development	biological process	GO:0007417	995	14	18204	49	ERBB4,GFAP,NAV2,PCDH9,DCLK2,NRG3,PRKG1,DCLK1,DAAM2,QKI,RFX4,SLC1A2,MSI2,BMPR1B
2.627e-07	-15.15	SYNM (synemin)	protein interactions	23336	54	5	19454	50	ERBB4,TNRC6A,PPP2R2B,DTNA,GFAP
2.894e-07	-15.06	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	11	16828	49	SLC39A11,PRKG1,RYR3,NRG3,CTNND2,FMN2,SOX5,PCDH9,LSAMP,PPP2R2B,ADCY2
8.499e-07	-13.98	trunk	COSMIC cancer mutations	trunk	3554	26	16828	49	RPS6KA2,ARAP2,MGAT4C,TRPS1,HPSE2,CTNND2,NPAS3,PCDH9,DPP10,LSAMP,DCLK1,RYR3,DCLK2,PPP2R2B,GLIS3,CDH20,ABR,NRG3,MACF1,SLC14A1,HIF3A,LIFR,SOX5,DST,ERBB4,TNRC6A
1.189e-06	-13.64	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	37	16828	49	FMN2,CTNND2,NTM,DAAM2,TRPS1,TRPM3,SORBS1,DCLK1,LSAMP,PCDH9,RPS6KA2,ARAP2,MGAT4C,PITPNC1,HIF3A,MACF1,NAV2,NRG3,GFAP,DTNA,PRKG1,CAMK2G,ADCY2,ERBB4,DST,SOX5,SLC1A2,DCLK2,RFX4,WDR49,RYR3,SLC39A11,ABR,CDH20,QKI,PPP2R2B,SLC25A18
1.565e-06	-13.37	nervous system development	biological process	GO:0007399	2185	19	18204	49	QKI,MSI2,BMPR1B,SOX5,CAMK2G,LSAMP,RFX4,SLC1A2,NAV2,ERBB4,GFAP,PRKG1,CTNND2,DCLK1,DAAM2,PCDH9,DCLK2,NRG3,NTM
1.845e-06	-13.20	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	42	16828	49	FMN2,CTNND2,NTM,HPSE2,DAAM2,TRPS1,SORBS1,TRPM3,DCLK1,LSAMP,NPAS3,PCDH9,DPP10,BMPR1B,RPS6KA2,ARAP2,PITPNC1,HIF3A,MACF1,NAV2,SLC14A1,DTNA,NRG3,MSI2,PRKG1,ADCY2,ERBB4,DST,LIFR,SLC1A2,SOX5,DCLK2,RFX4,RYR3,WDR49,SLC39A11,CDH20,ABR,QKI,GLIS3,PPP2R2B,SLC25A18
2.070e-06	-13.09	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	9	19454	50	ERBB4,ARAP2,FMN2,CTNND2,MACF1,DTNA,SLC25A18,DST,CAMK2G
2.232e-06	-13.01	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	14	16828	49	FMN2,NAV2,NRG3,PRKG1,ERBB4,TNRC6A,ADCY2,DST,SOX5,SLC1A2,RYR3,CDH20,ABR,QKI
2.259e-06	-13.00	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	22	16828	49	IQCA1,SOX5,SLC1A2,LIFR,ERBB4,ADCY2,DST,NRG3,PRKG1,HIF3A,NAV2,ABR,PPP2R2B,RFX4,RYR3,LSAMP,PCDH9,TRPS1,CTNND2,FMN2,DAAM2,HPSE2
3.494e-06	-12.56	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	RYR3,SLC39A11,QKI,PPP2R2B,PRKG1,NRG3,HPSE2,NAV2,FMN2,CTNND2,PCDH9,SOX5,LSAMP,ADCY2,TNRC6A,ERBB4
3.494e-06	-12.56	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	SLC39A11,RYR3,QKI,PPP2R2B,PRKG1,NRG3,NAV2,HPSE2,CTNND2,FMN2,SOX5,PCDH9,LSAMP,TNRC6A,ADCY2,ERBB4
3.596e-06	-12.54	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	37	16828	49	ARAP2,PITPNC1,AQP4,RPS6KA2,TRPM3,DCLK1,LSAMP,PCDH9,NPAS3,DPP10,FMN2,NTM,CTNND2,HPSE2,DAAM2,TRPS1,CDH20,ABR,QKI,DCLK2,RFX4,RYR3,WDR49,TNRC6A,ERBB4,ADCY2,DST,IQCA1,LIFR,SLC1A2,SOX5,MACF1,SLC14A1,NAV2,NRG3,GFAP,PRKG1
3.596e-06	-12.54	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	37	16828	49	TRPM3,DCLK1,LSAMP,DPP10,NPAS3,PCDH9,NTM,CTNND2,FMN2,DAAM2,HPSE2,TRPS1,ARAP2,PITPNC1,AQP4,RPS6KA2,ADCY2,TNRC6A,ERBB4,DST,IQCA1,SLC1A2,SOX5,LIFR,SLC14A1,NAV2,MACF1,NRG3,GFAP,PRKG1,CDH20,ABR,QKI,DCLK2,RFX4,RYR3,WDR49
4.752e-06	-12.26	brainstem	COSMIC cancer mutations	brainstem	3102	23	16828	49	ARAP2,LSAMP,DCLK1,NPAS3,PCDH9,CTNND2,FMN2,HPSE2,CDH20,QKI,PPP2R2B,WDR49,RYR3,TNRC6A,ADCY2,ERBB4,SLC1A2,SOX5,LIFR,SLC14A1,NAV2,NRG3,PRKG1
9.417e-06	-11.57	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	11	16828	49	SOX5,SLC1A2,PCDH9,LSAMP,ERBB4,ADCY2,SLC39A11,RYR3,NRG3,NAV2,HPSE2
1.002e-05	-11.51	cerebellum	COSMIC cancer mutations	cerebellum	769	11	16828	49	HPSE2,CTNND2,PRKG1,RYR3,NRG3,QKI,ERBB4,DPP10,PCDH9,NPAS3,IQCA1
1.114e-05	-11.41	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	20	16828	49	NRG3,PRKG1,CTNND2,FMN2,SLC14A1,NAV2,HPSE2,DCLK1,LSAMP,SOX5,PCDH9,LIFR,ERBB4,ADCY2,WDR49,RYR3,CDH20,ARAP2,PPP2R2B,QKI
1.199e-05	-11.33	forebrain development	biological process	GO:0030900	408	8	18204	49	ERBB4,DCLK1,PRKG1,NRG3,SLC1A2,RFX4,DCLK2,PCDH9
1.413e-05	-11.17	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	18	16828	49	PPP2R2B,RFX4,WDR49,RYR3,LSAMP,NPAS3,PCDH9,SOX5,BMPR1B,SLC1A2,ADCY2,ERBB4,NRG3,PRKG1,FMN2,CTNND2,HPSE2,NAV2
1.413e-05	-11.17	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	18	16828	49	NRG3,PRKG1,CTNND2,FMN2,NAV2,HPSE2,LSAMP,SLC1A2,SOX5,BMPR1B,NPAS3,PCDH9,ADCY2,ERBB4,RFX4,RYR3,WDR49,PPP2R2B
1.450e-05	-11.14	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	27	16828	49	MGAT4C,ARAP2,TRPS1,DAAM2,CTNND2,FMN2,DPP10,PCDH9,DCLK1,TRPM3,SLC39A11,WDR49,RYR3,RFX4,QKI,GLIS3,PRKG1,NRG3,DTNA,NAV2,MACF1,HIF3A,SOX5,LIFR,DST,ERBB4,ADCY2
1.450e-05	-11.14	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	27	16828	49	SOX5,LIFR,ADCY2,ERBB4,DST,DTNA,NRG3,PRKG1,HIF3A,NAV2,MACF1,GLIS3,QKI,RFX4,SLC39A11,RYR3,WDR49,DCLK1,DPP10,PCDH9,TRPM3,TRPS1,CTNND2,FMN2,DAAM2,MGAT4C,ARAP2
1.492e-05	-11.11	astrocyte projection	cellular component	GO:0097449	19	3	19108	49	GFAP,AQP4,SLC1A2
1.509e-05	-11.10	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	10	16828	49	PCDH9,NPAS3,DPP10,IQCA1,ERBB4,RYR3,PRKG1,NRG3,HPSE2,CTNND2
1.529e-05	-11.09	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	10	16828	49	RYR3,PRKG1,NRG3,HPSE2,CTNND2,DPP10,NPAS3,PCDH9,IQCA1,ERBB4
1.804e-05	-10.92	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	26	16828	49	AQP4,ARAP2,TRPS1,HPSE2,FMN2,CTNND2,PCDH9,DPP10,LSAMP,RYR3,WDR49,SLC39A11,QKI,PPP2R2B,CDH20,PRKG1,DTNA,NRG3,MACF1,NAV2,LIFR,SLC1A2,SOX5,DST,ADCY2,ERBB4
2.023e-05	-10.81	aspartate transmembrane transport	biological process	GO:0015810	20	3	18204	49	SLC25A18,SLC1A2,GFAP
2.045e-05	-10.80	SR_plectin_7	pfam domains	PF21097	3	2	17795	47	DST,MACF1
2.198e-05	-10.73	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	20	16828	49	RPS6KA2,RYR3,CDH20,ABR,ARAP2,PPP2R2B,MGAT4C,CTNND2,HPSE2,SLC14A1,NRG3,TRPS1,ERBB4,DST,LSAMP,DCLK1,LIFR,PCDH9,DPP10,SOX5
2.973e-05	-10.42	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	47	16828	49	MGAT4C,ARAP2,NTM,DAAM2,HPSE2,TRPS1,TRPM3,SORBS1,DPP10,BMPR1B,NPAS3,RYR3,WDR49,ABR,CDH20,PPP2R2B,MACF1,GFAP,DTNA,ERBB4,ADCY2,TNRC6A,DST,SLC1A2,LIFR,AQP4,RPS6KA2,PITPNC1,CTNND2,FMN2,LSAMP,DCLK1,PCDH9,DCLK2,RFX4,SLC39A11,GLIS3,QKI,SLC25A18,HIF3A,NAV2,NRG3,PRKG1,MSI2,CAMK2G,IQCA1,SOX5
3.062e-05	-10.39	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	26	16828	49	SORBS1,TRPM3,DCLK1,DPP10,PCDH9,CTNND2,NTM,FMN2,DAAM2,PTGDS,HPSE2,TRPS1,ARAP2,RPS6KA2,ADCY2,TNRC6A,SOX5,LIFR,HIF3A,MACF1,NRG3,PRKG1,CDH20,PPP2R2B,RFX4,RYR3
3.292e-05	-10.32	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	33	16828	49	SLC25A18,CDH20,ABR,QKI,PPP2R2B,RFX4,SLC39A11,RYR3,SLC1A2,SOX5,LIFR,ADCY2,ERBB4,DST,GFAP,NRG3,PRKG1,HIF3A,NAV2,MACF1,PITPNC1,MGAT4C,ARAP2,DCLK1,NPAS3,TRPM3,SORBS1,TRPS1,NTM,CTNND2,FMN2,DAAM2,HPSE2
3.403e-05	-10.29	Prot_kinase_dom	interpro domains	IPR000719	480	8	18521	49	PRKG1,DCLK1,RPS6KA2,DCLK2,BMPR1B,TTN,ERBB4,CAMK2G
3.684e-05	-10.21	mouth	COSMIC cancer mutations	mouth	9004	40	16828	49	DST,ADCY2,ERBB4,CAMK2G,SLC1A2,SOX5,LIFR,NAV2,MACF1,HIF3A,PRKG1,GFAP,DTNA,NRG3,QKI,PPP2R2B,CDH20,ABR,SLC25A18,DCLK2,SLC39A11,RYR3,WDR49,RFX4,SORBS1,TRPM3,NPAS3,PCDH9,DCLK1,LSAMP,DAAM2,HPSE2,NTM,CTNND2,FMN2,TRPS1,MGAT4C,ARAP2,PITPNC1,RPS6KA2
4.062e-05	-10.11	testis	COSMIC cancer mutations	testis	733	10	16828	49	BMPR1B,DCLK1,ABR,CAMK2G,ERBB4,PRKG1,TRPS1,RPS6KA2,MACF1,DCLK2
4.083e-05	-10.11	Spectrin_4	pfam domains	PF21020	4	2	17795	47	MACF1,DST
4.083e-05	-10.11	Spectrin_2	pfam domains	PF18373	4	2	17795	47	DST,MACF1
4.083e-05	-10.11	Spectrin_3	pfam domains	PF21019	4	2	17795	47	MACF1,DST
4.100e-05	-10.10	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	2	18521	49	DST,MACF1
4.100e-05	-10.10	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	2	18521	49	MACF1,DST
4.105e-05	-10.10	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	33	16828	49	DCLK2,RYR3,GLIS3,ABR,SLC25A18,MACF1,NAV2,HIF3A,PRKG1,NRG3,DST,ADCY2,ERBB4,LIFR,SOX5,IQCA1,RPS6KA2,AQP4,ARAP2,MGAT4C,PITPNC1,HPSE2,DAAM2,FMN2,CTNND2,TRPS1,TRPM3,SORBS1,NPAS3,PCDH9,DPP10,BMPR1B,DCLK1
4.265e-05	-10.06	system development	biological process	GO:0048731	3533	22	18204	49	MSI2,BMPR1B,SOX5,CAMK2G,LSAMP,HIF3A,SLC1A2,RFX4,TRPS1,TTN,QKI,CTNND2,DCLK1,PRKG1,DAAM2,PCDH9,NRG3,NTM,DCLK2,NAV2,GFAP,ERBB4
4.447e-05	-10.02	Nuclear signaling by ERBB4	REACTOME pathways	R-HSA-1251985	25	3	10285	29	ERBB4,GFAP,NRG3
4.562e-05	-10.00	C4-dicarboxylate transport	biological process	GO:0015740	26	3	18204	49	GFAP,SLC1A2,SLC25A18
4.681e-05	-9.97	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	35	16828	49	PITPNC1,ARAP2,RPS6KA2,PCDH9,NPAS3,DPP10,LSAMP,TRPM3,SORBS1,TRPS1,HPSE2,DAAM2,FMN2,CTNND2,NTM,PPP2R2B,GLIS3,QKI,ABR,RYR3,WDR49,SLC39A11,RFX4,DCLK2,LIFR,SLC1A2,SOX5,DST,ADCY2,ERBB4,TNRC6A,PRKG1,NRG3,MACF1,NAV2
5.002e-05	-9.90	LRRC7 (leucine rich repeat containing 7)	protein interactions	57554	28	3	19454	50	CTNND2,CAMK2G,ERBB4
5.007e-05	-9.90	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	24	16828	49	GLIS3,PPP2R2B,SLC39A11,RYR3,WDR49,SLC1A2,SOX5,LIFR,DST,ERBB4,ADCY2,PRKG1,NRG3,NAV2,HIF3A,MGAT4C,BMPR1B,PCDH9,LSAMP,DAAM2,HPSE2,CTNND2,NTM,FMN2
5.007e-05	-9.90	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	24	16828	49	MGAT4C,LSAMP,BMPR1B,PCDH9,NTM,CTNND2,FMN2,DAAM2,HPSE2,PPP2R2B,GLIS3,SLC39A11,WDR49,RYR3,ERBB4,ADCY2,DST,SOX5,SLC1A2,LIFR,HIF3A,NAV2,NRG3,PRKG1
5.552e-05	-9.80	KLHL15 (kelch like family member 15)	protein interactions	80311	81	4	19454	50	DCLK2,DCLK1,PPP2R2B,TNRC6A
5.633e-05	-9.78	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	7	18521	49	CAMK2G,DCLK2,RPS6KA2,BMPR1B,DCLK1,PRKG1,ERBB4
6.170e-05	-9.69	-	gene3d domains	1.20.58.1060	4	2	14470	47	DST,MACF1
6.236e-05	-9.68	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	23	16828	49	CDH20,PPP2R2B,QKI,SLC39A11,WDR49,RYR3,ERBB4,ADCY2,DST,SOX5,SLC1A2,LIFR,NAV2,MACF1,NRG3,PRKG1,ARAP2,AQP4,LSAMP,PCDH9,CTNND2,FMN2,HPSE2
6.236e-05	-9.68	Kinase-like_dom_sf	interpro domains	IPR011009	523	8	18521	49	TTN,BMPR1B,DCLK2,RPS6KA2,DCLK1,PRKG1,ERBB4,CAMK2G
6.710e-05	-9.61	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	10	16828	49	DCLK1,SOX5,BMPR1B,ERBB4,ADCY2,CAMK2G,PRKG1,DCLK2,CTNND2,RPS6KA2
6.710e-05	-9.61	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	10	16828	49	DCLK1,BMPR1B,SOX5,ADCY2,ERBB4,CAMK2G,PRKG1,CTNND2,DCLK2,RPS6KA2
6.826e-05	-9.59	RYR1 (ryanodine receptor 1)	protein interactions	6261	31	3	19454	50	CAMK2G,PRKG1,TTN
7.061e-05	-9.56	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	49	SLC1A2,GFAP
7.061e-05	-9.56	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	49	GFAP,SLC1A2
7.377e-05	-9.51	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	8	16828	49	DCLK1,BMPR1B,ERBB4,CAMK2G,PRKG1,DCLK2,RPS6KA2,MACF1
7.827e-05	-9.46	multicellular organism development	biological process	GO:0007275	3957	23	18204	49	ERBB4,NAV2,NRG3,PCDH9,DAAM2,DCLK1,PRKG1,TTN,SLC1A2,RFX4,LSAMP,CAMK2G,SOX5,BMPR1B,MSI2,GFAP,NTM,DCLK2,CTNND2,CDH20,QKI,TRPS1,HIF3A
7.923e-05	-9.44	non_seminoma	COSMIC cancer mutations	non_seminoma	492	8	16828	49	BMPR1B,DCLK1,CAMK2G,ERBB4,PRKG1,MACF1,RPS6KA2,DCLK2
7.933e-05	-9.44	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	6	16828	49	ADCY2,ERBB4,HPSE2,NRG3,PCDH9,NPAS3
7.933e-05	-9.44	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	6	16828	49	ERBB4,ADCY2,PCDH9,NPAS3,HPSE2,NRG3
9.079e-05	-9.31	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	48	16828	49	NPAS3,DPP10,BMPR1B,TRPM3,SORBS1,TRPS1,NTM,HPSE2,PTGDS,DAAM2,ARAP2,MGAT4C,LIFR,SLC1A2,ADCY2,TNRC6A,ERBB4,DST,GFAP,DTNA,MACF1,CDH20,ABR,PPP2R2B,RYR3,WDR49,DCLK1,LSAMP,PCDH9,FMN2,CTNND2,PITPNC1,RPS6KA2,IQCA1,SOX5,CAMK2G,NRG3,PRKG1,MSI2,HIF3A,SLC14A1,NAV2,SLC25A18,GLIS3,QKI,RFX4,SLC39A11,DCLK2
9.096e-05	-9.31	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	9	16828	49	DCLK1,BMPR1B,ABR,CAMK2G,ERBB4,PRKG1,TRPS1,DCLK2,RPS6KA2
9.632e-05	-9.25	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	8	16828	49	MGAT4C,TNRC6A,NPAS3,LIFR,DPP10,RPS6KA2,SLC14A1,PRKG1
1.017e-04	-9.19	GAS2	pfam domains	PF02187	6	2	17795	47	DST,MACF1
1.017e-04	-9.19	SH3_10	pfam domains	PF17902	6	2	17795	47	DST,MACF1
1.017e-04	-9.19	Plectin	pfam domains	PF00681	6	2	17795	47	DST,MACF1
1.022e-04	-9.19	Desmoplakin_SH3	interpro domains	IPR041615	6	2	18521	49	MACF1,DST
1.022e-04	-9.19	GAR_dom	interpro domains	IPR003108	6	2	18521	49	DST,MACF1
1.022e-04	-9.19	GAR_dom_sf	interpro domains	IPR036534	6	2	18521	49	MACF1,DST
1.046e-04	-9.17	pharynx	COSMIC cancer mutations	pharynx	2696	19	16828	49	QKI,PITPNC1,RPS6KA2,RYR3,WDR49,RFX4,DST,SORBS1,DPP10,SLC1A2,PCDH9,NPAS3,SLC14A1,DAAM2,MACF1,CTNND2,FMN2,NRG3,DTNA
1.057e-04	-9.15	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	2	18204	49	ERBB4,NRG3
1.057e-04	-9.15	D-amino acid transport	biological process	GO:0042940	6	2	18204	49	SLC1A2,GFAP
1.158e-04	-9.06	glial cell projection	cellular component	GO:0097386	37	3	19108	49	SLC1A2,AQP4,GFAP
1.317e-04	-8.94	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	16	16828	49	LSAMP,PCDH9,DPP10,ERBB4,DST,TRPM3,NRG3,GFAP,MSI2,TRPS1,FMN2,MACF1,NAV2,PPP2R2B,AQP4,RPS6KA2
1.350e-04	-8.91	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	6	19454	50	DCLK1,SORBS1,DTNA,TNRC6A,MACF1,DST
1.382e-04	-8.89	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	8	12186	40	CAMK2G,RPS6KA2,TTN,PRKG1,DCLK2,ERBB4,DCLK1,BMPR1B
1.428e-04	-8.85	Plectin_repeat	interpro domains	IPR001101	7	2	18521	49	MACF1,DST
1.428e-04	-8.85	Plakin_repeat_sf	interpro domains	IPR035915	7	2	18521	49	MACF1,DST
1.437e-04	-8.85	protein serine/threonine kinase activity	molecular function	GO:0004674	428	7	18094	49	BMPR1B,CAMK2G,DCLK2,PRKG1,TTN,RPS6KA2,DCLK1
1.449e-04	-8.84	protein kinase activity	molecular function	GO:0004672	577	8	18094	49	BMPR1B,DCLK2,CAMK2G,TTN,PRKG1,DCLK1,ERBB4,RPS6KA2
1.490e-04	-8.81	FLOT1 (flotillin 1)	protein interactions	10211	453	7	19454	50	SORBS1,DTNA,SLC14A1,MACF1,FMN2,SOX5,DST
1.495e-04	-8.81	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	43	16828	49	SOX5,IQCA1,CAMK2G,MSI2,PRKG1,NRG3,NAV2,GLIS3,QKI,SLC39A11,DCLK2,PCDH9,DCLK1,LSAMP,FMN2,CTNND2,RPS6KA2,LIFR,SLC1A2,DST,ADCY2,TNRC6A,ERBB4,DTNA,GFAP,MACF1,PPP2R2B,CDH20,ABR,WDR49,RYR3,NPAS3,BMPR1B,DPP10,SORBS1,TRPM3,TRPS1,HPSE2,PTGDS,DAAM2,NTM,ARAP2,MGAT4C
1.536e-04	-8.78	Plakin repeat	gene3d domains	3.90.1290.10	6	2	14470	47	MACF1,DST
1.536e-04	-8.78	Gas2-like domain	gene3d domains	3.30.920.20	6	2	14470	47	MACF1,DST
1.544e-04	-8.78	Ser/Thr_kinase_AS	interpro domains	IPR008271	308	6	18521	49	CAMK2G,PRKG1,DCLK1,BMPR1B,DCLK2,RPS6KA2
1.563e-04	-8.76	GAR	prosite domains	PS51460	6	2	12186	40	DST,MACF1
1.604e-04	-8.74	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	8	14470	47	CAMK2G,DCLK2,TTN,PRKG1,RPS6KA2,BMPR1B,DCLK1,ERBB4
1.608e-04	-8.74	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	8	16828	49	PRKG1,RPS6KA2,FMN2,DCLK2,BMPR1B,DCLK1,CAMK2G,ERBB4
1.627e-04	-8.72	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	5	19454	50	DCLK1,RYR3,CAMK2G,DTNA,DAAM2
1.628e-04	-8.72	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	8	16828	49	RPS6KA2,DCLK2,FMN2,PRKG1,ERBB4,CAMK2G,BMPR1B,DCLK1
1.633e-04	-8.72	seminoma	COSMIC cancer mutations	seminoma	700	9	16828	49	TRPS1,PRKG1,RPS6KA2,DCLK2,BMPR1B,DCLK1,ERBB4,CAMK2G,ABR
1.644e-04	-8.71	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	10	16828	49	PRKG1,TRPS1,DCLK2,MACF1,RPS6KA2,DCLK1,BMPR1B,ABR,CAMK2G,ERBB4
1.767e-04	-8.64	GAS2	smart domains	SM00243	6	2	9717	34	MACF1,DST
1.795e-04	-8.63	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	2	19454	50	NTM,GFAP
1.810e-04	-8.62	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	41	16828	49	DAAM2,HPSE2,CTNND2,NTM,FMN2,TRPS1,SORBS1,TRPM3,DPP10,BMPR1B,NPAS3,PCDH9,DCLK1,RPS6KA2,MGAT4C,ARAP2,PITPNC1,SLC14A1,NAV2,MACF1,HIF3A,PRKG1,MSI2,DTNA,NRG3,DST,ERBB4,TNRC6A,CAMK2G,SOX5,LIFR,DCLK2,SLC39A11,RYR3,WDR49,RFX4,QKI,PPP2R2B,ABR,CDH20,SLC25A18
1.838e-04	-8.60	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	41	16828	49	PITPNC1,ARAP2,MGAT4C,RPS6KA2,PCDH9,NPAS3,DPP10,BMPR1B,DCLK1,TRPM3,SORBS1,TRPS1,HPSE2,DAAM2,FMN2,NTM,CTNND2,SLC25A18,QKI,PPP2R2B,CDH20,ABR,WDR49,RYR3,SLC39A11,RFX4,DCLK2,LIFR,SOX5,DST,CAMK2G,TNRC6A,ERBB4,MSI2,PRKG1,NRG3,DTNA,MACF1,NAV2,SLC14A1,HIF3A
1.844e-04	-8.60	Circadian entrainment	KEGG pathways	ko04713	96	4	7161	22	PRKG1,RYR3,CAMK2G,ADCY2
1.844e-04	-8.60	Circadian entrainment	KEGG pathways	hsa04713	96	4	7161	22	ADCY2,CAMK2G,RYR3,PRKG1
1.893e-04	-8.57	DCX	pfam domains	PF03607	8	2	17795	47	DCLK2,DCLK1
1.901e-04	-8.57	Plakin	interpro domains	IPR043197	8	2	18521	49	DST,MACF1
1.967e-04	-8.53	ERBB4 signaling pathway	biological process	GO:0038130	8	2	18204	49	ERBB4,NRG3
1.980e-04	-8.53	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	7	12186	40	CAMK2G,RPS6KA2,DCLK1,BMPR1B,PRKG1,ERBB4,DCLK2
2.158e-04	-8.44	large_intestine-rectum	COSMIC cancer mutations	large_intestine-rectum	569	8	16828	49	DCLK1,DST,ADCY2,ERBB4,PRKG1,TRPS1,DAAM2,FMN2
2.293e-04	-8.38	astrocyte end-foot	cellular component	GO:0097450	9	2	19108	49	AQP4,GFAP
2.302e-04	-8.38	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	7	16828	49	DCLK1,PRKG1,BMPR1B,CAMK2G,ERBB4,DCLK2,RPS6KA2
2.302e-04	-8.38	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	7	16828	49	RPS6KA2,CAMK2G,ERBB4,DCLK2,PRKG1,BMPR1B,DCLK1
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	NTM,LSAMP
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	LSAMP,NTM
2.306e-04	-8.37	Signaling by ERBB4	REACTOME pathways	R-HSA-1236394	43	3	10285	29	NRG3,GFAP,ERBB4
2.355e-04	-8.35	face	COSMIC cancer mutations	face	2139	16	16828	49	MSI2,TRPS1,GFAP,NRG3,MACF1,NAV2,FMN2,PCDH9,DPP10,LSAMP,DST,TRPM3,ERBB4,RPS6KA2,AQP4,PPP2R2B
2.383e-04	-8.34	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	29	16828	49	SLC25A18,PPP2R2B,CDH20,RYR3,SLC39A11,LIFR,SOX5,ADCY2,TNRC6A,ERBB4,PRKG1,NRG3,DTNA,MACF1,NAV2,SLC14A1,ARAP2,MGAT4C,NPAS3,DPP10,LSAMP,DCLK1,TRPM3,SORBS1,TRPS1,HPSE2,FMN2,CTNND2,NTM
2.383e-04	-8.34	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	29	16828	49	ARAP2,MGAT4C,FMN2,CTNND2,NTM,HPSE2,TRPS1,SORBS1,TRPM3,LSAMP,DCLK1,NPAS3,DPP10,RYR3,SLC39A11,CDH20,PPP2R2B,SLC25A18,MACF1,SLC14A1,NAV2,DTNA,NRG3,PRKG1,TNRC6A,ERBB4,ADCY2,LIFR,SOX5
2.439e-04	-8.32	Doublecortin_dom	interpro domains	IPR003533	9	2	18521	49	DCLK1,DCLK2
2.468e-04	-8.31	PLEC	smart domains	SM00250	7	2	9717	34	MACF1,DST
2.790e-04	-8.18	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	11	16828	49	LIFR,ADCY2,ERBB4,SORBS1,PRKG1,NTM,CTNND2,MACF1,MGAT4C,ARAP2,PPP2R2B
2.829e-04	-8.17	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	7	10285	29	TNRC6A,NRG3,ADCY2,RPS6KA2,CAMK2G,ERBB4,ABR
2.833e-04	-8.17	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	35	16828	49	SOX5,SLC1A2,LIFR,DST,ERBB4,ADCY2,TNRC6A,CAMK2G,PRKG1,NRG3,NAV2,MACF1,SLC25A18,PPP2R2B,GLIS3,QKI,ABR,CDH20,SLC39A11,RYR3,WDR49,RFX4,DCLK2,BMPR1B,DPP10,PCDH9,DCLK1,LSAMP,TRPM3,TRPS1,HPSE2,CTNND2,FMN2,ARAP2,RPS6KA2
2.880e-04	-8.15	Pkinase	pfam domains	PF00069	347	6	17795	47	DCLK2,PRKG1,RPS6KA2,CAMK2G,DCLK1,TTN
2.894e-04	-8.15	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	23	16828	49	PITPNC1,ARAP2,AQP4,PCDH9,NPAS3,DPP10,TRPS1,FMN2,CTNND2,GLIS3,WDR49,RYR3,RFX4,SLC1A2,IQCA1,CAMK2G,ERBB4,TNRC6A,ADCY2,PRKG1,MACF1,NAV2,HIF3A
2.905e-04	-8.14	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	23	16828	49	SLC1A2,IQCA1,CAMK2G,ADCY2,TNRC6A,ERBB4,PRKG1,MACF1,NAV2,HIF3A,GLIS3,RYR3,WDR49,RFX4,PCDH9,NPAS3,DPP10,TRPS1,FMN2,CTNND2,PITPNC1,ARAP2,AQP4
2.977e-04	-8.12	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	10	16828	49	DCLK1,BMPR1B,ERBB4,CAMK2G,DST,PPP2R2B,PRKG1,DCLK2,MACF1,RPS6KA2
3.044e-04	-8.10	Doublecortin_dom_sf	interpro domains	IPR036572	10	2	18521	49	DCLK1,DCLK2
3.085e-04	-8.08	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	11	16828	49	LIFR,DCLK1,MGAT4C,ARAP2,ERBB4,CAMK2G,RYR3,PRKG1,NAV2,RPS6KA2,CTNND2
3.129e-04	-8.07	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	16	16828	49	HPSE2,NAV2,FMN2,CTNND2,PRKG1,NRG3,ERBB4,ADCY2,PCDH9,SOX5,SLC1A2,LSAMP,RYR3,SLC39A11,PPP2R2B,CDH20
3.129e-04	-8.07	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	16	16828	49	SLC39A11,RYR3,PPP2R2B,CDH20,PRKG1,NRG3,NAV2,HPSE2,CTNND2,FMN2,SOX5,SLC1A2,PCDH9,LSAMP,ADCY2,ERBB4
3.267e-04	-8.03	YES1 (YES proto-oncogene 1, Src family tyrosine kinase)	protein interactions	7525	364	6	19454	50	ERBB4,MSI2,CAMK2G,GFAP,SLC14A1,RPS6KA2
3.289e-04	-8.02	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	7	16828	49	BMPR1B,PRKG1,DCLK1,RPS6KA2,ERBB4,DCLK2,CAMK2G
3.318e-04	-8.01	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	23	16828	49	TRPS1,CTNND2,FMN2,DPP10,PCDH9,NPAS3,AQP4,PITPNC1,ARAP2,PRKG1,HIF3A,NAV2,MACF1,IQCA1,SLC1A2,ADCY2,ERBB4,TNRC6A,CAMK2G,RFX4,RYR3,WDR49,GLIS3
3.377e-04	-7.99	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	7	16828	49	RPS6KA2,DCLK2,ERBB4,CAMK2G,BMPR1B,PRKG1,DCLK1
3.407e-04	-7.98	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	2	10285	29	ERBB4,NRG3
3.409e-04	-7.98	plasma membrane	cellular component	GO:0005886	5538	26	19108	49	RYR3,SLC39A11,NRG3,TRPM3,SLC14A1,LIFR,PCDH9,DTNA,CTNND2,LSAMP,NTM,DCLK1,SLC1A2,MACF1,ADCY2,DPP10,SORBS1,AQP4,ERBB4,PRKG1,FMN2,DST,HPSE2,BMPR1B,CDH20,HIF3A
3.456e-04	-7.97	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	16	16828	49	ERBB4,ADCY2,PCDH9,SOX5,SLC1A2,LSAMP,HPSE2,NAV2,FMN2,CTNND2,PRKG1,NRG3,PPP2R2B,CDH20,RYR3,SLC39A11
3.471e-04	-7.97	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	43	16828	49	IQCA1,SOX5,CAMK2G,NRG3,PRKG1,MSI2,NAV2,QKI,GLIS3,SLC39A11,DCLK2,DCLK1,LSAMP,PCDH9,CTNND2,FMN2,RPS6KA2,SLC1A2,LIFR,ADCY2,ERBB4,TNRC6A,DST,GFAP,DTNA,MACF1,ABR,CDH20,PPP2R2B,WDR49,RYR3,DPP10,BMPR1B,NPAS3,SORBS1,TRPM3,TRPS1,NTM,PTGDS,DAAM2,HPSE2,MGAT4C,ARAP2
3.484e-04	-7.96	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	11	16828	49	CTNND2,NAV2,PRKG1,ERBB4,CAMK2G,DCLK1,LIFR,RPS6KA2,RYR3,MGAT4C,ARAP2
3.653e-04	-7.91	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	7	16828	49	BMPR1B,PRKG1,DCLK1,RPS6KA2,ERBB4,DCLK2,CAMK2G
3.664e-04	-7.91	Doublecortin domain	gene3d domains	3.10.20.230	9	2	14470	47	DCLK1,DCLK2
3.669e-04	-7.91	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	10	19454	50	DCLK1,NAV2,ARAP2,SORBS1,FMN2,MACF1,PITPNC1,DCLK2,CAMK2G,DST
3.727e-04	-7.89	DC	prosite domains	PS50309	9	2	12186	40	DCLK2,DCLK1
3.766e-04	-7.88	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	29	16828	49	MACF1,NAV2,NRG3,PRKG1,CAMK2G,ADCY2,TNRC6A,ERBB4,DST,SLC1A2,SOX5,RYR3,SLC39A11,CDH20,PPP2R2B,GLIS3,FMN2,CTNND2,HPSE2,TRPS1,SORBS1,TRPM3,LSAMP,DCLK1,PCDH9,NPAS3,DPP10,AQP4,ARAP2
3.844e-04	-7.86	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	49	SLC1A2,SLC25A18
3.906e-04	-7.85	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	49	SOX5,BMPR1B,TRPS1
4.018e-04	-7.82	ear	COSMIC cancer mutations	ear	624	8	16828	49	DPP10,LIFR,NPAS3,TNRC6A,MGAT4C,PRKG1,SLC14A1,RPS6KA2
4.044e-04	-7.81	mucosal	COSMIC cancer mutations	mucosal	2009	15	16828	49	WDR49,ABR,MGAT4C,ARAP2,PPP2R2B,NRG3,CTNND2,FMN2,NAV2,DCLK1,BMPR1B,PCDH9,LIFR,ERBB4,SORBS1
4.044e-04	-7.81	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	15	16828	49	NRG3,NAV2,FMN2,CTNND2,LIFR,PCDH9,BMPR1B,DCLK1,SORBS1,ERBB4,WDR49,ARAP2,PPP2R2B,MGAT4C,ABR
4.163e-04	-7.78	protein serine kinase activity	molecular function	GO:0106310	362	6	18094	49	DCLK2,DCLK1,CAMK2G,RPS6KA2,PRKG1,TTN
4.201e-04	-7.77	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	8	10285	29	RYR3,SLC1A2,CAMK2G,SLC14A1,ADCY2,AQP4,SLC25A18,TRPM3
4.213e-04	-7.77	DCX	smart domains	SM00537	9	2	9717	34	DCLK1,DCLK2
4.467e-04	-7.71	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	8	16828	49	DCLK1,ERBB4,CAMK2G,SORBS1,PPP2R2B,NTM,FMN2,RPS6KA2
4.618e-04	-7.68	PROTEIN_KINASE_ST	prosite domains	PS00108	308	6	12186	40	RPS6KA2,CAMK2G,PRKG1,DCLK2,DCLK1,BMPR1B
4.667e-04	-7.67	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	8	18094	49	BMPR1B,DCLK2,CAMK2G,TTN,PRKG1,DCLK1,RPS6KA2,ERBB4
4.778e-04	-7.65	sarcolemma	cellular component	GO:0042383	142	4	19108	49	DTNA,AQP4,PRKG1,RYR3
5.195e-04	-7.56	cell periphery	cellular component	GO:0071944	6020	27	19108	49	NAV2,HPSE2,CDH20,HIF3A,BMPR1B,SORBS1,AQP4,ERBB4,DPP10,ADCY2,MACF1,FMN2,DST,PRKG1,CTNND2,LSAMP,NTM,SLC1A2,DCLK1,LIFR,TRPM3,SLC14A1,SLC39A11,NRG3,RYR3,DTNA,PCDH9
5.849e-04	-7.44	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	7	16828	49	DCLK2,ERBB4,CAMK2G,RPS6KA2,DCLK1,BMPR1B,PRKG1
5.874e-04	-7.44	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	2	10285	29	NRG3,ERBB4
6.126e-04	-7.40	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	8	16828	49	DCLK2,RPS6KA2,PRKG1,ERBB4,CAMK2G,DCLK1,BMPR1B,LIFR
6.212e-04	-7.38	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	6	10285	29	ERBB4,CAMK2G,NRG3,TNRC6A,ADCY2,RPS6KA2
6.276e-04	-7.37	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	7	16828	49	DCLK2,RPS6KA2,PRKG1,CAMK2G,ERBB4,DCLK1,BMPR1B
6.372e-04	-7.36	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	8	16828	49	CAMK2G,ERBB4,LIFR,BMPR1B,DCLK1,RPS6KA2,DCLK2,PRKG1
6.401e-04	-7.35	brain development	biological process	GO:0007420	724	8	18204	49	ERBB4,NRG3,SLC1A2,DCLK2,RFX4,PCDH9,DCLK1,PRKG1
6.403e-04	-7.35	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	49	SLC1A2,SLC25A18
6.697e-04	-7.31	phosphorylation	biological process	GO:0016310	729	8	18204	49	DCLK2,RPS6KA2,ERBB4,CAMK2G,BMPR1B,TTN,PRKG1,DCLK1
6.754e-04	-7.30	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	9	16828	49	DCLK1,LIFR,BMPR1B,DPP10,CAMK2G,ERBB4,PRKG1,DCLK2,RPS6KA2
6.754e-04	-7.30	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	9	16828	49	PRKG1,RPS6KA2,DCLK2,LIFR,BMPR1B,DPP10,DCLK1,CAMK2G,ERBB4
6.805e-04	-7.29	atypical	COSMIC cancer mutations	atypical	515	7	16828	49	DCLK1,PRKG1,BMPR1B,CAMK2G,DCLK2,ERBB4,RPS6KA2
6.841e-04	-7.29	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	2	10285	29	NRG3,ERBB4
6.844e-04	-7.29	neurogenesis	biological process	GO:0022008	1334	11	18204	49	ERBB4,GFAP,NAV2,DCLK2,NTM,PRKG1,DCLK1,CTNND2,QKI,BMPR1B,SOX5
6.850e-04	-7.29	scalp	COSMIC cancer mutations	scalp	2110	15	16828	49	PPP2R2B,RPS6KA2,DCLK1,LSAMP,SOX5,CAMK2G,ERBB4,SORBS1,DST,GFAP,PRKG1,TRPS1,FMN2,NTM,MACF1
6.998e-04	-7.26	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	9	19454	50	DCLK2,PITPNC1,DST,CAMK2G,DCLK1,ARAP2,NAV2,SORBS1,MACF1
7.014e-04	-7.26	FH2	pfam domains	PF02181	15	2	17795	47	DAAM2,FMN2
7.043e-04	-7.26	FH2_Formin_sf	interpro domains	IPR042201	15	2	18521	49	FMN2,DAAM2
7.043e-04	-7.26	FH2_Formin	interpro domains	IPR015425	15	2	18521	49	DAAM2,FMN2
7.348e-04	-7.22	CH	pfam domains	PF00307	67	3	17795	47	DST,MACF1,NAV2
7.616e-04	-7.18	kinase activity	molecular function	GO:0016301	739	8	18094	49	BMPR1B,DCLK2,CAMK2G,PRKG1,TTN,DCLK1,ERBB4,RPS6KA2
7.643e-04	-7.18	anatomical structure development	biological process	GO:0048856	5207	25	18204	49	HIF3A,CDH20,QKI,TRPS1,TNRC6A,NTM,DCLK2,CTNND2,GFAP,FMN2,SLC1A2,RFX4,LSAMP,CAMK2G,BMPR1B,SOX5,MSI2,TTN,NRG3,PCDH9,DAAM2,DCLK1,PRKG1,ERBB4,NAV2
7.686e-04	-7.17	adenoma	COSMIC cancer mutations	adenoma	2873	18	16828	49	BMPR1B,SOX5,LIFR,NPAS3,PCDH9,TRPM3,DST,ERBB4,ADCY2,PRKG1,HPSE2,MACF1,CTNND2,HIF3A,CDH20,RYR3,WDR49,DCLK2
7.879e-04	-7.15	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	2	10285	29	NRG3,ERBB4
8.340e-04	-7.09	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	11	16828	49	ABR,ADCY2,MACF1,RPS6KA2,HPSE2,FMN2,CTNND2,NTM,RYR3,TRPS1,NRG3
8.340e-04	-7.09	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	11	16828	49	MACF1,HPSE2,RPS6KA2,FMN2,CTNND2,NTM,RYR3,TRPS1,NRG3,ABR,ADCY2
8.541e-04	-7.07	telencephalon development	biological process	GO:0021537	276	5	18204	49	ERBB4,NRG3,SLC1A2,DCLK2,RFX4
8.793e-04	-7.04	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	10	19454	50	DCLK1,ARAP2,NAV2,SORBS1,MACF1,FMN2,PITPNC1,DCLK2,CAMK2G,DST
8.989e-04	-7.01	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	2	10285	29	ERBB4,NRG3
8.989e-04	-7.01	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	2	10285	29	ERBB4,NRG3
9.010e-04	-7.01	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	12	16828	49	RYR3,WDR49,DST,SORBS1,NPAS3,PCDH9,SLC14A1,DAAM2,MACF1,FMN2,NRG3,DTNA
9.736e-04	-6.93	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	14	16828	49	BMPR1B,SOX5,PCDH9,NPAS3,DST,TNRC6A,ERBB4,DAAM2,MACF1,HPSE2,FMN2,MGAT4C,SLC39A11,RYR3
9.835e-04	-6.92	larynx	COSMIC cancer mutations	larynx	1948	14	16828	49	SLC39A11,RYR3,MGAT4C,FMN2,DAAM2,HPSE2,MACF1,TNRC6A,ERBB4,DST,BMPR1B,SOX5,PCDH9,NPAS3
9.860e-04	-6.92	cell junction assembly	biological process	GO:0034329	285	5	18204	49	CDH20,NRG3,ERBB4,DST,SORBS1
9.890e-04	-6.92	head development	biological process	GO:0060322	774	8	18204	49	ERBB4,PCDH9,SLC1A2,NRG3,RFX4,DCLK2,DCLK1,PRKG1
9.985e-04	-6.91	regulation of cartilage development	biological process	GO:0061035	73	3	18204	49	TRPS1,SOX5,BMPR1B
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	LSAMP,GFAP,NTM
1.055e-03	-6.85	PPP1R9B (protein phosphatase 1 regulatory subunit 9B)	protein interactions	84687	175	4	19454	50	RPS6KA2,DCLK2,NAV2,DCLK1
1.055e-03	-6.85	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	2	14470	47	FMN2,DAAM2
1.061e-03	-6.85	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	3	19454	50	MSI2,SLC25A18,SOX5
1.066e-03	-6.84	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	7	16828	49	CTNND2,RYR3,PRKG1,TRPS1,ADCY2,ERBB4,LIFR
1.069e-03	-6.84	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	49	SLC1A2,SLC25A18
1.074e-03	-6.84	FH2	prosite domains	PS51444	15	2	12186	40	DAAM2,FMN2
1.075e-03	-6.84	nodular	COSMIC cancer mutations	nodular	1515	12	16828	49	NPAS3,ERBB4,TNRC6A,CTNND2,HIF3A,FMN2,MACF1,CDH20,GLIS3,ARAP2,WDR49,DCLK2
1.075e-03	-6.84	actin binding	molecular function	GO:0003779	434	6	18094	49	MACF1,FMN2,SORBS1,DST,DAAM2,TTN
1.077e-03	-6.83	OSM (oncostatin M)	protein interactions	5008	19	2	19454	50	TRPM3,LIFR
1.089e-03	-6.82	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	7	16828	49	TRPS1,RYR3,PRKG1,CTNND2,LIFR,ADCY2,ERBB4
1.135e-03	-6.78	PAS	pfam domains	PF00989	19	2	17795	47	HIF3A,NPAS3
1.139e-03	-6.78	PAS_fold	interpro domains	IPR013767	19	2	18521	49	NPAS3,HIF3A
1.162e-03	-6.76	S_TKc	smart domains	SM00220	348	6	9717	34	DCLK1,CAMK2G,RPS6KA2,BMPR1B,PRKG1,DCLK2
1.165e-03	-6.76	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	49	16828	49	CTNND2,FMN2,DCLK1,LSAMP,PCDH9,AQP4,RPS6KA2,PITPNC1,NRG3,MSI2,PRKG1,HIF3A,NAV2,SLC14A1,IQCA1,SOX5,CAMK2G,RFX4,SLC39A11,DCLK2,SLC25A18,QKI,GLIS3,TRPS1,NTM,DAAM2,PTGDS,HPSE2,DPP10,BMPR1B,NPAS3,SORBS1,TRPM3,MGAT4C,ARAP2,GFAP,DTNA,MACF1,SLC1A2,LIFR,ERBB4,ADCY2,TNRC6A,DST,WDR49,RYR3,ABR,CDH20,PPP2R2B
1.172e-03	-6.75	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	5	19454	50	DST,DTNA,FMN2,MACF1,ARAP2
1.179e-03	-6.74	cartilage condensation	biological process	GO:0001502	19	2	18204	49	SOX5,BMPR1B
1.193e-03	-6.73	water transmembrane transporter activity	molecular function	GO:0005372	19	2	18094	49	SLC14A1,AQP4
1.201e-03	-6.72	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	18	16828	49	DST,TRPM3,ADCY2,ERBB4,DPP10,BMPR1B,LIFR,NPAS3,NAV2,MACF1,NTM,FMN2,HIF3A,PRKG1,MSI2,NRG3,PPP2R2B,RPS6KA2
1.201e-03	-6.72	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	18	16828	49	LIFR,NPAS3,DPP10,BMPR1B,ERBB4,ADCY2,DST,TRPM3,NRG3,PRKG1,MSI2,FMN2,HIF3A,NTM,MACF1,NAV2,PPP2R2B,RPS6KA2
1.210e-03	-6.72	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	49	SLC25A18,GFAP,SLC1A2
1.213e-03	-6.71	FH2	smart domains	SM00498	15	2	9717	34	FMN2,DAAM2
1.220e-03	-6.71	PRPH (peripherin)	protein interactions	5630	182	4	19454	50	TNRC6A,PPP2R2B,GFAP,SORBS1
1.222e-03	-6.71	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	9	16828	49	ERBB4,ADCY2,PPP2R2B,ARAP2,SORBS1,MGAT4C,LIFR,CTNND2,MACF1
1.284e-03	-6.66	CH_dom	interpro domains	IPR001715	81	3	18521	49	DST,MACF1,NAV2
1.307e-03	-6.64	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	49	BMPR1B,SOX5
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	MACF1,SORBS1
1.331e-03	-6.62	CH_dom_sf	interpro domains	IPR036872	82	3	18521	49	DST,NAV2,MACF1
1.357e-03	-6.60	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	14	19108	49	CTNND2,IQCA1,GFAP,SLC1A2,BMPR1B,AQP4,MACF1,ADCY2,FMN2,DTNA,ABR,PCDH9,DST,CAMK2G
1.443e-03	-6.54	cell aggregation	biological process	GO:0098743	21	2	18204	49	SOX5,BMPR1B
1.491e-03	-6.51	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	8	16828	49	RPS6KA2,DCLK2,PRKG1,ERBB4,CAMK2G,CDH20,BMPR1B,DCLK1
1.491e-03	-6.51	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	8	16828	49	ERBB4,CDH20,CAMK2G,DCLK1,BMPR1B,DCLK2,RPS6KA2,PRKG1
1.530e-03	-6.48	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	48	16828	49	SLC39A11,RFX4,DCLK2,SLC25A18,GLIS3,QKI,MSI2,PRKG1,NRG3,SLC14A1,NAV2,HIF3A,SOX5,IQCA1,CAMK2G,RPS6KA2,PITPNC1,CTNND2,FMN2,PCDH9,DCLK1,LSAMP,WDR49,RYR3,PPP2R2B,ABR,CDH20,GFAP,DTNA,MACF1,SLC1A2,LIFR,DST,ERBB4,ADCY2,TNRC6A,MGAT4C,ARAP2,TRPS1,DAAM2,PTGDS,HPSE2,NTM,BMPR1B,DPP10,NPAS3,TRPM3,SORBS1
1.541e-03	-6.48	CH	smart domains	SM00033	66	3	9717	34	DST,NAV2,MACF1
1.548e-03	-6.47	SFN (stratifin)	protein interactions	2810	671	7	19454	50	DST,PPP2R2B,FMN2,MACF1,NAV2,ARAP2,SORBS1
1.571e-03	-6.46	ATP binding	molecular function	GO:0005524	1467	11	18094	49	IQCA1,TTN,ERBB4,BMPR1B,NAV2,CAMK2G,DCLK2,ADCY2,PRKG1,RPS6KA2,DCLK1
1.581e-03	-6.45	cytoskeleton organization	biological process	GO:0007010	1251	10	18204	49	DST,IQCA1,MACF1,DCLK2,PRKG1,DAAM2,GFAP,FMN2,TTN,SORBS1
1.582e-03	-6.45	Rbm38 (RNA binding motif protein 38)	protein interactions	56190	23	2	19454	50	MSI2,QKI
1.582e-03	-6.45	TIMM10B (translocase of inner mitochondrial membrane 10B)	protein interactions	26515	23	2	19454	50	MSI2,HPSE2
1.584e-03	-6.45	protein kinase A signaling	biological process	GO:0010737	22	2	18204	49	TTN,PRKG1
1.620e-03	-6.43	OCLN (occludin)	protein interactions	100506658	495	6	19454	50	RPS6KA2,MACF1,FMN2,DTNA,DST,ARAP2
1.648e-03	-6.41	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	6	16828	49	PRKG1,BMPR1B,DCLK1,RPS6KA2,CAMK2G,ERBB4
1.674e-03	-6.39	Actinin_actin-bd_CS	interpro domains	IPR001589	23	2	18521	49	MACF1,DST
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	49	16828	49	SLC39A11,RFX4,DCLK2,SLC25A18,QKI,GLIS3,PRKG1,MSI2,NRG3,SLC14A1,NAV2,HIF3A,SOX5,IQCA1,CAMK2G,RPS6KA2,AQP4,PITPNC1,FMN2,CTNND2,PCDH9,LSAMP,DCLK1,RYR3,WDR49,PPP2R2B,ABR,CDH20,GFAP,DTNA,MACF1,LIFR,SLC1A2,DST,ADCY2,ERBB4,TNRC6A,ARAP2,MGAT4C,TRPS1,HPSE2,PTGDS,DAAM2,NTM,NPAS3,DPP10,BMPR1B,TRPM3,SORBS1
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	49	16828	49	PPP2R2B,CDH20,ABR,WDR49,RYR3,SLC1A2,LIFR,DST,ADCY2,TNRC6A,ERBB4,DTNA,GFAP,MACF1,MGAT4C,ARAP2,BMPR1B,DPP10,NPAS3,TRPM3,SORBS1,TRPS1,PTGDS,DAAM2,HPSE2,NTM,SLC25A18,QKI,GLIS3,SLC39A11,RFX4,DCLK2,SOX5,IQCA1,CAMK2G,PRKG1,MSI2,NRG3,SLC14A1,NAV2,HIF3A,PITPNC1,RPS6KA2,AQP4,PCDH9,LSAMP,DCLK1,CTNND2,FMN2
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	49	16828	49	ERBB4,ADCY2,TNRC6A,DST,SLC1A2,LIFR,MACF1,GFAP,DTNA,ABR,CDH20,PPP2R2B,WDR49,RYR3,TRPM3,SORBS1,BMPR1B,DPP10,NPAS3,NTM,PTGDS,DAAM2,HPSE2,TRPS1,MGAT4C,ARAP2,CAMK2G,IQCA1,SOX5,HIF3A,SLC14A1,NAV2,NRG3,PRKG1,MSI2,GLIS3,QKI,SLC25A18,DCLK2,RFX4,SLC39A11,LSAMP,DCLK1,PCDH9,CTNND2,FMN2,PITPNC1,AQP4,RPS6KA2
1.675e-03	-6.39	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	49	16828	49	ARAP2,MGAT4C,SORBS1,TRPM3,NPAS3,DPP10,BMPR1B,HPSE2,DAAM2,PTGDS,NTM,TRPS1,PPP2R2B,CDH20,ABR,WDR49,RYR3,DST,ERBB4,TNRC6A,ADCY2,LIFR,SLC1A2,MACF1,GFAP,DTNA,PITPNC1,RPS6KA2,AQP4,PCDH9,DCLK1,LSAMP,FMN2,CTNND2,GLIS3,QKI,SLC25A18,DCLK2,SLC39A11,RFX4,CAMK2G,SOX5,IQCA1,SLC14A1,NAV2,HIF3A,PRKG1,MSI2,NRG3
1.681e-03	-6.39	classic	COSMIC cancer mutations	classic	14774	49	16828	49	SORBS1,TRPM3,NPAS3,BMPR1B,DPP10,HPSE2,DAAM2,PTGDS,NTM,TRPS1,ARAP2,MGAT4C,DST,TNRC6A,ADCY2,ERBB4,LIFR,SLC1A2,MACF1,GFAP,DTNA,PPP2R2B,ABR,CDH20,RYR3,WDR49,PCDH9,DCLK1,LSAMP,FMN2,CTNND2,PITPNC1,RPS6KA2,AQP4,CAMK2G,SOX5,IQCA1,NAV2,SLC14A1,HIF3A,PRKG1,MSI2,NRG3,GLIS3,QKI,SLC25A18,DCLK2,SLC39A11,RFX4
1.704e-03	-6.38	medulla	COSMIC cancer mutations	medulla	14778	49	16828	49	DST,ADCY2,TNRC6A,ERBB4,LIFR,SLC1A2,MACF1,GFAP,DTNA,PPP2R2B,ABR,CDH20,RYR3,WDR49,SORBS1,TRPM3,NPAS3,DPP10,BMPR1B,HPSE2,PTGDS,DAAM2,NTM,TRPS1,ARAP2,MGAT4C,CAMK2G,SOX5,IQCA1,SLC14A1,NAV2,HIF3A,PRKG1,MSI2,NRG3,QKI,GLIS3,SLC25A18,DCLK2,SLC39A11,RFX4,PCDH9,LSAMP,DCLK1,FMN2,CTNND2,PITPNC1,RPS6KA2,AQP4
1.709e-03	-6.37	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	49	16828	49	PITPNC1,AQP4,RPS6KA2,DCLK1,LSAMP,PCDH9,CTNND2,FMN2,SLC25A18,GLIS3,QKI,RFX4,SLC39A11,DCLK2,IQCA1,SOX5,CAMK2G,NRG3,MSI2,PRKG1,HIF3A,SLC14A1,NAV2,MGAT4C,ARAP2,BMPR1B,DPP10,NPAS3,SORBS1,TRPM3,TRPS1,NTM,PTGDS,DAAM2,HPSE2,CDH20,ABR,PPP2R2B,RYR3,WDR49,SLC1A2,LIFR,ADCY2,ERBB4,TNRC6A,DST,DTNA,GFAP,MACF1
1.712e-03	-6.37	SHC1 events in ERBB2 signaling	REACTOME pathways	R-HSA-1250196	22	2	10285	29	NRG3,ERBB4
1.762e-03	-6.34	DMRTB1 (DMRT like family B with proline rich C-terminal 1)	protein interactions	63948	93	3	19454	50	MSI2,QKI,TNRC6A
1.774e-03	-6.33	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	5	16828	49	FMN2,ADCY2,PPP2R2B,PRKG1,SOX5
1.816e-03	-6.31	Spectrin	pfam domains	PF00435	24	2	17795	47	MACF1,DST
1.823e-03	-6.31	Spectrin_repeat	interpro domains	IPR002017	24	2	18521	49	MACF1,DST
1.854e-03	-6.29	bladder	COSMIC cancer mutations	bladder	14112	48	16828	49	SLC25A18,GLIS3,QKI,RFX4,SLC39A11,DCLK2,IQCA1,SOX5,CAMK2G,NRG3,PRKG1,MSI2,HIF3A,NAV2,SLC14A1,PITPNC1,RPS6KA2,LSAMP,DCLK1,PCDH9,FMN2,CTNND2,CDH20,ABR,PPP2R2B,WDR49,RYR3,LIFR,SLC1A2,ERBB4,ADCY2,TNRC6A,DST,GFAP,DTNA,MACF1,ARAP2,MGAT4C,NPAS3,BMPR1B,DPP10,SORBS1,TRPM3,TRPS1,NTM,HPSE2,DAAM2,PTGDS
1.854e-03	-6.29	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	48	16828	49	NRG3,MSI2,PRKG1,HIF3A,SLC14A1,NAV2,IQCA1,SOX5,CAMK2G,RFX4,SLC39A11,DCLK2,SLC25A18,QKI,GLIS3,CTNND2,FMN2,DCLK1,LSAMP,PCDH9,RPS6KA2,PITPNC1,GFAP,DTNA,MACF1,SLC1A2,LIFR,ERBB4,ADCY2,TNRC6A,DST,RYR3,WDR49,CDH20,ABR,PPP2R2B,TRPS1,NTM,DAAM2,PTGDS,HPSE2,BMPR1B,DPP10,NPAS3,SORBS1,TRPM3,MGAT4C,ARAP2
1.856e-03	-6.29	multicellular organismal process	biological process	GO:0032501	6177	27	18204	49	PCDH9,NRG3,DCLK1,PRKG1,DAAM2,ERBB4,NAV2,PTGDS,CAMK2G,LSAMP,SLC1A2,RFX4,MSI2,BMPR1B,SOX5,TTN,NTM,DCLK2,CTNND2,GFAP,RYR3,HIF3A,AQP4,QKI,DTNA,CDH20,TRPS1
1.874e-03	-6.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	14	16828	49	DCLK1,BMPR1B,SOX5,ERBB4,ADCY2,CAMK2G,GFAP,DTNA,TRPS1,PRKG1,DAAM2,SLC25A18,DCLK2,RPS6KA2
1.913e-03	-6.26	human chr2q37.2-q37.3	chromosome location	human chr2q37.2-q37.3	1	1	26134	50	IQCA1
1.913e-03	-6.26	human chr10q11.23-q21.1	chromosome location	human chr10q11.23-q21.1	1	1	26134	50	PRKG1
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr12q21.31-q21.32	chromosome location	human chr12q21.31-q21.32	1	1	26134	50	MGAT4C
1.913e-03	-6.26	human chr17q24.3-q25.1	chromosome location	human chr17q24.3-q25.1	1	1	26134	50	SLC39A11
1.913e-03	-6.26	human chr4q31.23-q31.3	chromosome location	human chr4q31.23-q31.3	1	1	26134	50	DCLK2
1.945e-03	-6.24	protein tetramerization	biological process	GO:0051262	92	3	18204	49	AQP4,TRPM3,RYR3
1.957e-03	-6.24	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	4	16828	49	NRG3,RYR3,PCDH9,SLC39A11
1.964e-03	-6.23	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	9	19454	50	MSI2,AQP4,CAMK2G,TRPM3,SORBS1,LSAMP,QKI,MACF1,TRPS1
1.984e-03	-6.22	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	49	16828	49	HIF3A,NAV2,SLC14A1,NRG3,PRKG1,MSI2,CAMK2G,IQCA1,SOX5,DCLK2,RFX4,SLC39A11,QKI,GLIS3,SLC25A18,CTNND2,FMN2,DCLK1,LSAMP,PCDH9,AQP4,RPS6KA2,PITPNC1,MACF1,DTNA,GFAP,ADCY2,ERBB4,TNRC6A,DST,SLC1A2,LIFR,WDR49,RYR3,ABR,CDH20,PPP2R2B,NTM,DAAM2,PTGDS,HPSE2,TRPS1,TRPM3,SORBS1,DPP10,BMPR1B,NPAS3,MGAT4C,ARAP2
2.006e-03	-6.21	intermediate filament cytoskeleton organization	biological process	GO:0045104	93	3	18204	49	GFAP,DST,MACF1
2.022e-03	-6.20	Calcium signaling pathway	KEGG pathways	hsa04020	181	4	7161	22	ADCY2,CAMK2G,RYR3,ERBB4
2.022e-03	-6.20	Calcium signaling pathway	KEGG pathways	ko04020	181	4	7161	22	ERBB4,RYR3,ADCY2,CAMK2G
2.047e-03	-6.19	MED27 (mediator complex subunit 27)	protein interactions	9442	98	3	19454	50	SOX5,QKI,TNRC6A
2.047e-03	-6.19	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	49	SLC1A2,SLC25A18
2.069e-03	-6.18	intermediate filament-based process	biological process	GO:0045103	94	3	18204	49	MACF1,GFAP,DST
2.112e-03	-6.16	ErbB signaling pathway	KEGG pathways	ko04012	85	3	7161	22	NRG3,CAMK2G,ERBB4
2.112e-03	-6.16	ErbB signaling pathway	KEGG pathways	hsa04012	85	3	7161	22	NRG3,CAMK2G,ERBB4
2.127e-03	-6.15	large_cell	COSMIC cancer mutations	large_cell	14845	49	16828	49	SOX5,IQCA1,CAMK2G,MSI2,PRKG1,NRG3,SLC14A1,NAV2,HIF3A,SLC25A18,QKI,GLIS3,SLC39A11,RFX4,DCLK2,PCDH9,LSAMP,DCLK1,CTNND2,FMN2,PITPNC1,RPS6KA2,AQP4,SLC1A2,LIFR,DST,ERBB4,ADCY2,TNRC6A,DTNA,GFAP,MACF1,PPP2R2B,ABR,CDH20,WDR49,RYR3,BMPR1B,DPP10,NPAS3,SORBS1,TRPM3,TRPS1,DAAM2,PTGDS,HPSE2,NTM,MGAT4C,ARAP2
2.137e-03	-6.15	Calponin-like domain	gene3d domains	1.10.418.10	79	3	14470	47	DST,MACF1,NAV2
2.161e-03	-6.14	cell projection	cellular component	GO:0042995	2398	14	19108	49	BMPR1B,SLC1A2,GFAP,CTNND2,IQCA1,CAMK2G,FMN2,ABR,DTNA,PCDH9,DST,ADCY2,MACF1,AQP4
2.176e-03	-6.13	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	11	18094	49	RPS6KA2,DCLK1,PRKG1,ADCY2,CAMK2G,DCLK2,BMPR1B,NAV2,ERBB4,TTN,IQCA1
2.181e-03	-6.13	MBNL2 (muscleblind like splicing regulator 2)	protein interactions	10150	27	2	19454	50	MSI2,QKI
2.181e-03	-6.13	ANKRD1 (ankyrin repeat domain 1)	protein interactions	27063	27	2	19454	50	TTN,DST
2.185e-03	-6.13	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	7	19454	50	ERBB4,MSI2,ARAP2,FMN2,MACF1,DST,DTNA
2.198e-03	-6.12	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	10	16828	49	PRKG1,NRG3,HPSE2,CTNND2,AQP4,PCDH9,SOX5,DPP10,LSAMP,ADCY2
2.262e-03	-6.09	amino acid transmembrane transport	biological process	GO:0003333	97	3	18204	49	SLC1A2,GFAP,SLC25A18
2.342e-03	-6.06	CH	prosite domains	PS50021	81	3	12186	40	DST,MACF1,NAV2
2.419e-03	-6.02	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	29	TTN,SORBS1,RYR3,CAMK2G
2.487e-03	-6.00	Salivary secretion	KEGG pathways	hsa04970	90	3	7161	22	ADCY2,RYR3,PRKG1
2.487e-03	-6.00	Salivary secretion	KEGG pathways	ko04970	90	3	7161	22	PRKG1,RYR3,ADCY2
2.495e-03	-5.99	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	37	16828	49	TRPM3,SORBS1,DCLK1,LSAMP,PCDH9,BMPR1B,FMN2,CTNND2,HPSE2,DAAM2,PTGDS,TRPS1,MGAT4C,PITPNC1,RPS6KA2,CAMK2G,ERBB4,ADCY2,TNRC6A,DST,IQCA1,LIFR,SOX5,HIF3A,MACF1,NAV2,MSI2,PRKG1,ABR,CDH20,PPP2R2B,QKI,GLIS3,DCLK2,WDR49,RYR3,SLC39A11
2.535e-03	-5.98	signaling	biological process	GO:0023052	4968	23	18204	49	ADCY2,ARAP2,NRG3,MACF1,ABR,DST,DAAM2,PRKG1,DCLK1,ERBB4,SLC1A2,CAMK2G,PITPNC1,BMPR1B,RPS6KA2,TTN,DCLK2,CTNND2,FMN2,LIFR,RYR3,DTNA,SORBS1
2.545e-03	-5.97	ACTININ_2	prosite domains	PS00020	23	2	12186	40	MACF1,DST
2.545e-03	-5.97	ACTININ_1	prosite domains	PS00019	23	2	12186	40	MACF1,DST
2.564e-03	-5.97	H zone	cellular component	GO:0031673	1	1	19108	49	DST
2.566e-03	-5.97	water transport	biological process	GO:0006833	28	2	18204	49	SLC14A1,AQP4
2.570e-03	-5.96	IML3 (Iml3p)	protein interactions	852404	1	1	19454	50	GFAP
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	AGO4 (Argonaute family protein)	protein interactions	817246	1	1	19454	50	TNRC6A
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	EB1a (microtubule end binding protein EB1A)	protein interactions	823923	1	1	19454	50	DST
2.570e-03	-5.96	mal3 (EB1 family Mal3)	protein interactions	2542123	1	1	19454	50	DST
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.603e-03	-5.95	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	4	19454	50	DST,MACF1,DCLK1,NAV2
2.641e-03	-5.94	STAR_dimer	pfam domains	PF16544	1	1	17795	47	QKI
2.641e-03	-5.94	Quaking_NLS	pfam domains	PF16551	1	1	17795	47	QKI
2.641e-03	-5.94	LIFR_N	pfam domains	PF18207	1	1	17795	47	LIFR
2.641e-03	-5.94	PKcGMP_CC	pfam domains	PF16808	1	1	17795	47	PRKG1
2.641e-03	-5.94	Titin_Z	pfam domains	PF09042	1	1	17795	47	TTN
2.641e-03	-5.94	PPAK	pfam domains	PF02818	1	1	17795	47	TTN
2.645e-03	-5.94	tibia	COSMIC cancer mutations	tibia	836	8	16828	49	MACF1,CTNND2,PRKG1,QKI,TRPM3,DST,LSAMP,DCLK1
2.646e-03	-5.93	RSK3_STKc	interpro domains	IPR042766	1	1	18521	49	RPS6KA2
2.646e-03	-5.93	LIFR_N	interpro domains	IPR040901	1	1	18521	49	LIFR
2.646e-03	-5.93	PKcGMP_CC	interpro domains	IPR031831	1	1	18521	49	PRKG1
2.646e-03	-5.93	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	49	SORBS1
2.646e-03	-5.93	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	49	SORBS1
2.646e-03	-5.93	TRPS1	interpro domains	IPR028440	1	1	18521	49	TRPS1
2.646e-03	-5.93	STAR_dimer	interpro domains	IPR032377	1	1	18521	49	QKI
2.646e-03	-5.93	Titin_Z_rpt	interpro domains	IPR015129	1	1	18521	49	TTN
2.646e-03	-5.93	TNRC6A_RRM	interpro domains	IPR034924	1	1	18521	49	TNRC6A
2.646e-03	-5.93	Quaking_NLS	interpro domains	IPR032367	1	1	18521	49	QKI
2.646e-03	-5.93	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	49	SORBS1
2.646e-03	-5.93	PPAK_motif	interpro domains	IPR004168	1	1	18521	49	TTN
2.646e-03	-5.93	ABR_PH	interpro domains	IPR037865	1	1	18521	49	ABR
2.692e-03	-5.92	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	49	NRG3
2.692e-03	-5.92	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	49	NRG3
2.692e-03	-5.92	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	49	FMN2
2.698e-03	-5.92	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	3	19454	50	ERBB4,MSI2,RYR3
2.708e-03	-5.91	internal N(7)-methylguanine-containing RNA reader activity	molecular function	GO:0160089	1	1	18094	49	QKI
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	PITPNC1,AQP4,RPS6KA2,LSAMP,DCLK1,PCDH9,FMN2,CTNND2,GLIS3,QKI,SLC25A18,DCLK2,RFX4,SLC39A11,CAMK2G,IQCA1,SOX5,HIF3A,NAV2,SLC14A1,NRG3,PRKG1,ARAP2,MGAT4C,TRPM3,SORBS1,NPAS3,BMPR1B,DPP10,NTM,HPSE2,DAAM2,PTGDS,TRPS1,CDH20,ABR,PPP2R2B,RYR3,WDR49,TNRC6A,ADCY2,ERBB4,DST,LIFR,SLC1A2,MACF1,GFAP,DTNA
2.724e-03	-5.91	transferase activity, transferring phosphorus-containing groups	molecular function	GO:0016772	903	8	18094	49	ERBB4,RPS6KA2,CAMK2G,DCLK1,DCLK2,TTN,PRKG1,BMPR1B
2.752e-03	-5.90	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	5	10285	29	ERBB4,CAMK2G,NRG3,TNRC6A,ADCY2
2.784e-03	-5.88	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	49	SLC25A18,SLC1A2
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	RYR3,WDR49,ABR,CDH20,PPP2R2B,DTNA,GFAP,MACF1,SLC1A2,LIFR,ERBB4,ADCY2,TNRC6A,DST,MGAT4C,ARAP2,TRPS1,NTM,PTGDS,DAAM2,HPSE2,BMPR1B,DPP10,NPAS3,SORBS1,TRPM3,RFX4,SLC39A11,DCLK2,SLC25A18,GLIS3,QKI,NRG3,PRKG1,HIF3A,SLC14A1,NAV2,IQCA1,SOX5,CAMK2G,AQP4,RPS6KA2,PITPNC1,CTNND2,FMN2,LSAMP,DCLK1,PCDH9
2.845e-03	-5.86	Spectrin/alpha-actinin	interpro domains	IPR018159	30	2	18521	49	MACF1,DST
2.853e-03	-5.86	cell communication	biological process	GO:0007154	5010	23	18204	49	ERBB4,DAAM2,PRKG1,DCLK1,ADCY2,ARAP2,NRG3,MACF1,ABR,DST,TTN,RPS6KA2,PITPNC1,BMPR1B,SLC1A2,CAMK2G,LIFR,FMN2,CTNND2,DCLK2,SORBS1,DTNA,RYR3
2.890e-03	-5.85	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	5	10285	29	ADCY2,TNRC6A,NRG3,CAMK2G,ERBB4
2.916e-03	-5.84	cell junction organization	biological process	GO:0034330	532	6	18204	49	ERBB4,DST,CDH20,NRG3,CTNND2,SORBS1
2.934e-03	-5.83	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	7	18094	49	SLC39A11,AQP4,SLC1A2,RYR3,TRPM3,SLC25A18,SLC14A1
2.942e-03	-5.83	L-glutamate import	biological process	GO:0051938	30	2	18204	49	SLC25A18,SLC1A2
2.973e-03	-5.82	CREB phosphorylation through the activation of Ras	REACTOME pathways	R-HSA-442742	29	2	10285	29	CAMK2G,RPS6KA2
3.026e-03	-5.80	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	4	10285	29	CAMK2G,SLC1A2,ADCY2,RPS6KA2
3.132e-03	-5.77	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	14	16828	49	CAMK2G,ERBB4,ADCY2,DCLK1,SOX5,BMPR1B,DAAM2,DTNA,GFAP,PRKG1,TRPS1,SLC25A18,DCLK2,RPS6KA2
3.180e-03	-5.75	Downregulation of ERBB2 signaling	REACTOME pathways	R-HSA-8863795	30	2	10285	29	NRG3,ERBB4
3.182e-03	-5.75	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	5	10285	29	ERBB4,CAMK2G,ADCY2,NRG3,TNRC6A
3.204e-03	-5.74	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	43	16828	49	HIF3A,NAV2,MACF1,DTNA,NRG3,PRKG1,TNRC6A,ERBB4,ADCY2,DST,IQCA1,SLC1A2,SOX5,LIFR,DCLK2,RFX4,SLC39A11,RYR3,WDR49,CDH20,ABR,GLIS3,QKI,PPP2R2B,SLC25A18,NTM,CTNND2,FMN2,DAAM2,HPSE2,TRPS1,TRPM3,SORBS1,LSAMP,DCLK1,BMPR1B,DPP10,PCDH9,NPAS3,RPS6KA2,MGAT4C,ARAP2,PITPNC1
3.212e-03	-5.74	cell junction	cellular component	GO:0030054	2224	13	19108	49	CTNND2,QKI,CDH20,RPS6KA2,SLC1A2,DCLK1,SORBS1,ERBB4,NRG3,DTNA,ABR,DST,PCDH9
3.237e-03	-5.73	cervix	COSMIC cancer mutations	cervix	11793	43	16828	49	PCDH9,DCLK1,LSAMP,CTNND2,FMN2,PITPNC1,RPS6KA2,SOX5,IQCA1,NAV2,HIF3A,PRKG1,NRG3,QKI,GLIS3,SLC25A18,DCLK2,SLC39A11,RFX4,TRPM3,SORBS1,DPP10,BMPR1B,NPAS3,DAAM2,HPSE2,NTM,TRPS1,MGAT4C,ARAP2,DST,ERBB4,ADCY2,TNRC6A,SLC1A2,LIFR,MACF1,DTNA,PPP2R2B,CDH20,ABR,WDR49,RYR3
3.248e-03	-5.73	-	gene3d domains	6.10.250.880	1	1	14470	47	ERBB4
3.248e-03	-5.73	-	gene3d domains	1.20.5.4010	1	1	14470	47	QKI
3.249e-03	-5.73	NTM (neurotrimin)	protein interactions	50863	33	2	19454	50	LSAMP,NTM
3.252e-03	-5.73	AQUAPORIN4	prints domains	PR02016	1	1	5227	17	AQP4
3.270e-03	-5.72	developmental process	biological process	GO:0032502	5716	25	18204	49	CTNND2,DCLK2,NTM,FMN2,GFAP,HIF3A,TRPS1,TNRC6A,CDH20,QKI,DAAM2,PRKG1,DCLK1,NRG3,PCDH9,NAV2,ERBB4,SOX5,BMPR1B,MSI2,RFX4,SLC1A2,CAMK2G,LSAMP,TTN
3.336e-03	-5.70	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	6	19454	50	ARAP2,ERBB4,DTNA,PCDH9,DST,MACF1
3.344e-03	-5.70	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	49	BMPR1B,SOX5
3.349e-03	-5.70	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	19	16828	49	NRG3,GFAP,FMN2,CTNND2,MACF1,HPSE2,NAV2,IQCA1,PCDH9,SOX5,DPP10,ADCY2,TNRC6A,TRPM3,DST,RYR3,SLC39A11,RPS6KA2,ARAP2
3.352e-03	-5.70	intermediate filament cytoskeleton	cellular component	GO:0045111	241	4	19108	49	DTNA,DST,MACF1,GFAP
3.371e-03	-5.69	middle_third	COSMIC cancer mutations	middle_third	3533	19	16828	49	TNRC6A,ADCY2,DST,TRPM3,IQCA1,SOX5,DPP10,PCDH9,CTNND2,FMN2,NAV2,HPSE2,MACF1,NRG3,GFAP,ARAP2,RPS6KA2,SLC39A11,RYR3
3.376e-03	-5.69	generation of neurons	biological process	GO:0048699	1158	9	18204	49	ERBB4,GFAP,DCLK2,NTM,PRKG1,CTNND2,DCLK1,SOX5,BMPR1B
3.390e-03	-5.69	PAS	smart domains	SM00091	25	2	9717	34	HIF3A,NPAS3
3.400e-03	-5.68	regulation of gliogenesis	biological process	GO:0014013	112	3	18204	49	QKI,GFAP,DAAM2
3.442e-03	-5.67	adenyl nucleotide binding	molecular function	GO:0030554	1620	11	18094	49	ADCY2,TTN,PRKG1,ERBB4,RPS6KA2,DCLK1,BMPR1B,NAV2,IQCA1,CAMK2G,DCLK2
3.454e-03	-5.67	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	5	10285	29	CAMK2G,ERBB4,TNRC6A,NRG3,ADCY2
3.465e-03	-5.67	TTC3 (tetratricopeptide repeat domain 3)	protein interactions	7267	118	3	19454	50	TTN,DST,DAAM2
3.486e-03	-5.66	dendrite development	biological process	GO:0016358	113	3	18204	49	PRKG1,DCLK1,CTNND2
3.499e-03	-5.66	DELLA	smart domains	SM01129	1	1	9717	34	MACF1
3.531e-03	-5.65	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	3	16828	49	PRKG1,NRG3,QKI
3.548e-03	-5.64	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	10	16828	49	NPAS3,GLIS3,ARAP2,ERBB4,TNRC6A,CDH20,MACF1,CTNND2,DCLK2,HIF3A
3.619e-03	-5.62	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	4	16828	49	NAV2,MGAT4C,DTNA,RFX4
3.644e-03	-5.61	PAS	interpro domains	IPR000014	34	2	18521	49	NPAS3,HIF3A
3.644e-03	-5.61	PAS-like_dom_sf	interpro domains	IPR035965	34	2	18521	49	NPAS3,HIF3A
3.656e-03	-5.61	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	21	16828	49	AQP4,RYR3,WDR49,ARAP2,GLIS3,ABR,NAV2,MACF1,CTNND2,HIF3A,TRPS1,PRKG1,DTNA,TRPM3,DST,ADCY2,ERBB4,SOX5,PCDH9,LIFR,LSAMP
3.658e-03	-5.61	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	5	10285	29	CAMK2G,ERBB4,TNRC6A,NRG3,ADCY2
3.803e-03	-5.57	anion binding	molecular function	GO:0043168	2412	14	18094	49	IQCA1,PITPNC1,TTN,ERBB4,BMPR1B,NAV2,DCLK2,PTGDS,ARAP2,CAMK2G,PRKG1,ADCY2,DCLK1,RPS6KA2
3.857e-03	-5.56	C1QTNF9 (C1q and TNF related 9)	protein interactions	338872	36	2	19454	50	DST,TTN
3.897e-03	-5.55	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	10	16828	49	ERBB4,SORBS1,TRPM3,ARAP2,DPP10,NPAS3,NTM,NAV2,MACF1,TRPS1
4.032e-03	-5.51	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	48	16828	49	SORBS1,TRPM3,DPP10,BMPR1B,NPAS3,DAAM2,HPSE2,NTM,TRPS1,MGAT4C,ARAP2,DST,ERBB4,ADCY2,TNRC6A,SLC1A2,LIFR,MACF1,GFAP,DTNA,PPP2R2B,ABR,CDH20,WDR49,RYR3,PCDH9,DCLK1,LSAMP,CTNND2,FMN2,PITPNC1,RPS6KA2,AQP4,CAMK2G,SOX5,IQCA1,SLC14A1,NAV2,HIF3A,PRKG1,MSI2,NRG3,QKI,GLIS3,SLC25A18,DCLK2,SLC39A11,RFX4
4.071e-03	-5.50	MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2)	protein interactions	9863	37	2	19454	50	CTNND2,ERBB4
4.071e-03	-5.50	TH (tyrosine hydroxylase)	protein interactions	7054	37	2	19454	50	CAMK2G,DAAM2
4.073e-03	-5.50	SOCS6 (suppressor of cytokine signaling 6)	protein interactions	9306	125	3	19454	50	DST,BMPR1B,ERBB4
4.117e-03	-5.49	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	4	16828	49	RFX4,DTNA,NAV2,MGAT4C
4.127e-03	-5.49	striated muscle contraction	biological process	GO:0006941	120	3	18204	49	RYR3,DTNA,TTN
4.258e-03	-5.46	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	3	19454	50	MACF1,DTNA,DST
4.290e-03	-5.45	Pcbp1 (poly(rC) binding protein 1)	protein interactions	23983	38	2	19454	50	QKI,MSI2
4.312e-03	-5.45	PAS	prosite domains	PS50112	30	2	12186	40	HIF3A,NPAS3
4.413e-03	-5.42	arm	COSMIC cancer mutations	arm	1331	10	16828	49	DPP10,NPAS3,SORBS1,TRPM3,ARAP2,ERBB4,TRPS1,NAV2,MACF1,NTM
4.448e-03	-5.42	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	3	16828	49	SOX5,SLC1A2,RYR3
4.451e-03	-5.41	cardiac muscle hypertrophy	biological process	GO:0003300	37	2	18204	49	PRKG1,TTN
4.451e-03	-5.41	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	49	SLC1A2,SORBS1
4.451e-03	-5.41	negative regulation of protein localization to nucleus	biological process	GO:1900181	37	2	18204	49	DCLK1,DCLK2
4.493e-03	-5.41	A band	cellular component	GO:0031672	39	2	19108	49	TTN,DST
4.494e-03	-5.41	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	4	19454	50	MACF1,FMN2,DTNA,DST
4.512e-03	-5.40	Z disc	cellular component	GO:0030018	130	3	19108	49	DST,TTN,RYR3
4.515e-03	-5.40	MYBPC2 (myosin binding protein C2)	protein interactions	4606	39	2	19454	50	TTN,DST
4.548e-03	-5.39	SPEC	smart domains	SM00150	29	2	9717	34	DST,MACF1
4.576e-03	-5.39	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	41	16828	49	TRPM3,BMPR1B,DPP10,PCDH9,NPAS3,LSAMP,DCLK1,DAAM2,HPSE2,CTNND2,NTM,FMN2,ARAP2,RPS6KA2,DST,ERBB4,ADCY2,TNRC6A,CAMK2G,SOX5,SLC1A2,LIFR,IQCA1,NAV2,SLC14A1,MACF1,HIF3A,PRKG1,MSI2,GFAP,DTNA,NRG3,QKI,GLIS3,PPP2R2B,CDH20,DCLK2,SLC39A11,RYR3,WDR49,RFX4
4.691e-03	-5.36	fluid transport	biological process	GO:0042044	38	2	18204	49	SLC14A1,AQP4
4.691e-03	-5.36	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	49	SLC1A2,GFAP
4.691e-03	-5.36	striated muscle hypertrophy	biological process	GO:0014897	38	2	18204	49	PRKG1,TTN
4.768e-03	-5.35	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	49	MACF1,RYR3,DST,DTNA
4.810e-03	-5.34	Post NMDA receptor activation events	REACTOME pathways	R-HSA-438064	37	2	10285	29	RPS6KA2,CAMK2G
4.852e-03	-5.33	cellular process	biological process	GO:0009987	14996	47	18204	49	DCLK2,LIFR,FMN2,GFAP,HPSE2,PPP2R2B,TNRC6A,SLC14A1,PRKG1,ABR,MACF1,NRG3,ADCY2,ERBB4,BMPR1B,PITPNC1,SOX5,RFX4,TTN,RPS6KA2,CTNND2,MGAT4C,SLC25A18,NTM,AQP4,GLIS3,HIF3A,RYR3,SORBS1,DPP10,QKI,CDH20,DTNA,DCLK1,DAAM2,PCDH9,DST,ARAP2,SLC39A11,PTGDS,NAV2,MSI2,IQCA1,CAMK2G,LSAMP,TRPM3,SLC1A2
4.858e-03	-5.33	humerus	COSMIC cancer mutations	humerus	546	6	16828	49	PRKG1,SOX5,HIF3A,FMN2,ADCY2,PPP2R2B
4.929e-03	-5.31	protein complex oligomerization	biological process	GO:0051259	256	4	18204	49	AQP4,TRPM3,SLC1A2,RYR3
4.936e-03	-5.31	cellular response to alkaloid	biological process	GO:0071312	39	2	18204	49	SLC1A2,RYR3
4.945e-03	-5.31	ARL4C (ADP ribosylation factor like GTPase 4C)	protein interactions	10123	134	3	19454	50	PCDH9,ARAP2,TTN
4.988e-03	-5.30	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	5	16828	49	LIFR,DCLK1,RPS6KA2,CAMK2G,ERBB4
4.988e-03	-5.30	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	5	16828	49	CAMK2G,ERBB4,RPS6KA2,DCLK1,LIFR
4.988e-03	-5.30	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	5	16828	49	LIFR,DCLK1,RPS6KA2,CAMK2G,ERBB4
4.988e-03	-5.30	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	5	16828	49	DCLK1,LIFR,ERBB4,CAMK2G,RPS6KA2
4.988e-03	-5.30	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	5	16828	49	LIFR,DCLK1,RPS6KA2,ERBB4,CAMK2G
5.049e-03	-5.29	Myo1c (myosin IC)	protein interactions	17913	135	3	19454	50	TRPS1,CAMK2G,DST
5.049e-03	-5.29	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	3	19454	50	ERBB4,DTNA,DST
5.085e-03	-5.28	PIP3 activates AKT signaling	REACTOME pathways	R-HSA-1257604	125	3	10285	29	ERBB4,NRG3,TNRC6A
5.098e-03	-5.28	I-set	pfam domains	PF07679	132	3	17795	47	TTN,LSAMP,NTM
5.131e-03	-5.27	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	3	16828	49	DST,CTNND2,FMN2
5.133e-03	-5.27	Ig_I-set	interpro domains	IPR013098	132	3	18521	49	NTM,TTN,LSAMP
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	ORF43 (ORF43)	protein interactions	4961497	2	1	19454	50	DAAM2
5.134e-03	-5.27	cdh11.S (cadherin 11 S homeolog)	protein interactions	100337621	2	1	19454	50	ERBB4
5.134e-03	-5.27	TRIM39-RPP21 (TRIM39-RPP21 readthrough)	protein interactions	202658	2	1	19454	50	PRKG1
5.134e-03	-5.27	URA1 (dihydroorotate dehydrogenase)	protein interactions	853664	2	1	19454	50	GFAP
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	EST1 (Est1p)	protein interactions	850934	2	1	19454	50	NAV2
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.187e-03	-5.26	muscle hypertrophy	biological process	GO:0014896	40	2	18204	49	PRKG1,TTN
5.271e-03	-5.25	carboxylic acid transmembrane transport	biological process	GO:1905039	131	3	18204	49	SLC1A2,GFAP,SLC25A18
5.276e-03	-5.24	LIFR_D2	pfam domains	PF17971	2	1	17795	47	LIFR
5.276e-03	-5.24	LIF-R_Ig-like	pfam domains	PF21177	2	1	17795	47	LIFR
5.276e-03	-5.24	UT	pfam domains	PF03253	2	1	17795	47	SLC14A1
5.276e-03	-5.24	Bcr-Abl_Oligo	pfam domains	PF09036	2	1	17795	47	ABR
5.276e-03	-5.24	Glyco_hydro_79n	pfam domains	PF03662	2	1	17795	47	HPSE2
5.284e-03	-5.24	cGMP_dep_kinase	interpro domains	IPR002374	2	1	18521	49	PRKG1
5.284e-03	-5.24	Bcr-Abl_oncoprot_oligo	interpro domains	IPR015123	2	1	18521	49	ABR
5.284e-03	-5.24	MSI_RRM2	interpro domains	IPR034126	2	1	18521	49	MSI2
5.284e-03	-5.24	LIF-R-like_Ig-like	interpro domains	IPR048497	2	1	18521	49	LIFR
5.284e-03	-5.24	Abr/Bcr	interpro domains	IPR037769	2	1	18521	49	ABR
5.284e-03	-5.24	DCX_chordates	interpro domains	IPR017302	2	1	18521	49	DCLK1
5.284e-03	-5.24	Bcr-Abl_oncoprot_oligo_sf	interpro domains	IPR036481	2	1	18521	49	ABR
5.284e-03	-5.24	Urea_transporter	interpro domains	IPR004937	2	1	18521	49	SLC14A1
5.284e-03	-5.24	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	49	FMN2
5.284e-03	-5.24	Distrobrevin	interpro domains	IPR017432	2	1	18521	49	DTNA
5.284e-03	-5.24	STKc_cGK	interpro domains	IPR035014	2	1	18521	49	PRKG1
5.284e-03	-5.24	LIFR_D2	interpro domains	IPR040817	2	1	18521	49	LIFR
5.284e-03	-5.24	Glyco_hydro_79	interpro domains	IPR005199	2	1	18521	49	HPSE2
5.356e-03	-5.23	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	10	16828	49	TNRC6A,ERBB4,TRPM3,DCLK1,PCDH9,CTNND2,HPSE2,MACF1,RYR3,WDR49
5.376e-03	-5.23	myofibroblast contraction	biological process	GO:1990764	2	1	18204	49	QKI
5.376e-03	-5.23	negative regulation of 3'-UTR-mediated mRNA stabilization	biological process	GO:1905869	2	1	18204	49	QKI
5.376e-03	-5.23	negative regulation of inositol phosphate biosynthetic process	biological process	GO:0010920	2	1	18204	49	PRKG1
5.376e-03	-5.23	establishment of planar polarity involved in nephron morphogenesis	biological process	GO:0072046	2	1	18204	49	ERBB4
5.383e-03	-5.22	amino acid transport	biological process	GO:0006865	132	3	18204	49	SLC25A18,SLC1A2,GFAP
5.386e-03	-5.22	membrane	cellular component	GO:0016020	9220	33	19108	49	CAMK2G,DTNA,PCDH9,TRPM3,SLC14A1,SLC25A18,SLC39A11,RYR3,NRG3,LIFR,DCLK1,PTGDS,SLC1A2,PPP2R2B,GFAP,NTM,LSAMP,CTNND2,PRKG1,ABR,DST,FMN2,DPP10,ADCY2,MACF1,ERBB4,AQP4,SORBS1,BMPR1B,HIF3A,CDH20,MGAT4C,HPSE2
5.409e-03	-5.22	heparanase activity	molecular function	GO:0030305	2	1	18094	49	HPSE2
5.409e-03	-5.22	cGMP-dependent protein kinase activity	molecular function	GO:0004692	2	1	18094	49	PRKG1
5.409e-03	-5.22	leukemia inhibitory factor receptor activity	molecular function	GO:0004923	2	1	18094	49	LIFR
5.432e-03	-5.22	GAB1 signalosome	REACTOME pathways	R-HSA-180292	128	3	10285	29	ERBB4,TNRC6A,NRG3
5.432e-03	-5.22	PI3K/AKT activation	REACTOME pathways	R-HSA-198203	128	3	10285	29	ERBB4,NRG3,TNRC6A
5.440e-03	-5.21	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	2	19108	49	RYR3,CAMK2G
5.443e-03	-5.21	cell-substrate junction assembly	biological process	GO:0007044	41	2	18204	49	DST,SORBS1
5.462e-03	-5.21	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	49	16828	49	WDR49,RYR3,ABR,CDH20,PPP2R2B,GFAP,DTNA,MACF1,LIFR,SLC1A2,ERBB4,ADCY2,TNRC6A,DST,ARAP2,MGAT4C,TRPS1,NTM,HPSE2,DAAM2,PTGDS,NPAS3,DPP10,BMPR1B,SORBS1,TRPM3,RFX4,SLC39A11,DCLK2,SLC25A18,QKI,GLIS3,NRG3,PRKG1,MSI2,HIF3A,SLC14A1,NAV2,IQCA1,SOX5,CAMK2G,AQP4,RPS6KA2,PITPNC1,FMN2,CTNND2,DCLK1,LSAMP,PCDH9
5.501e-03	-5.20	growth	biological process	GO:0040007	424	5	18204	49	BMPR1B,DCLK1,PRKG1,SLC1A2,ERBB4
5.501e-03	-5.20	developmental growth	biological process	GO:0048589	424	5	18204	49	DCLK1,PRKG1,BMPR1B,ERBB4,SLC1A2
5.535e-03	-5.20	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	6	16828	49	RPS6KA2,ERBB4,CAMK2G,RYR3,LIFR,DCLK1
5.601e-03	-5.18	Oocyte meiosis	KEGG pathways	ko04114	120	3	7161	22	CAMK2G,ADCY2,RPS6KA2
5.601e-03	-5.18	Oocyte meiosis	KEGG pathways	hsa04114	120	3	7161	22	RPS6KA2,ADCY2,CAMK2G
5.625e-03	-5.18	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	7	16828	49	DPP10,SOX5,ARAP2,DTNA,TRPS1,PRKG1,CTNND2
5.717e-03	-5.16	SH2D1A (SH2 domain containing 1A)	protein interactions	4068	44	2	19454	50	CAMK2G,ERBB4
5.729e-03	-5.16	organic acid transmembrane transport	biological process	GO:1903825	135	3	18204	49	SLC1A2,GFAP,SLC25A18
5.739e-03	-5.16	-	gene3d domains	1.20.58.60	35	2	14470	47	DST,MACF1
5.752e-03	-5.16	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	10	16828	49	WDR49,RYR3,HPSE2,MACF1,CTNND2,PCDH9,DCLK1,TRPM3,ERBB4,TNRC6A
5.755e-03	-5.16	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	47	16828	49	DAAM2,PTGDS,HPSE2,TRPS1,TRPM3,SORBS1,DPP10,BMPR1B,NPAS3,MGAT4C,ARAP2,MACF1,DTNA,GFAP,DST,TNRC6A,ADCY2,ERBB4,SLC1A2,LIFR,WDR49,RYR3,PPP2R2B,ABR,CDH20,CTNND2,FMN2,PCDH9,DCLK1,LSAMP,RPS6KA2,AQP4,PITPNC1,SLC14A1,NAV2,HIF3A,MSI2,PRKG1,NRG3,CAMK2G,SOX5,IQCA1,DCLK2,SLC39A11,QKI,GLIS3,SLC25A18
5.755e-03	-5.16	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	47	16828	49	TRPS1,PTGDS,DAAM2,HPSE2,BMPR1B,DPP10,NPAS3,SORBS1,TRPM3,MGAT4C,ARAP2,GFAP,DTNA,MACF1,SLC1A2,LIFR,ADCY2,ERBB4,TNRC6A,DST,RYR3,WDR49,CDH20,ABR,PPP2R2B,CTNND2,FMN2,LSAMP,DCLK1,PCDH9,AQP4,RPS6KA2,PITPNC1,NRG3,MSI2,PRKG1,HIF3A,NAV2,SLC14A1,IQCA1,SOX5,CAMK2G,SLC39A11,DCLK2,SLC25A18,GLIS3,QKI
5.771e-03	-5.15	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	49	16828	49	BMPR1B,DPP10,NPAS3,TRPM3,SORBS1,TRPS1,PTGDS,DAAM2,HPSE2,NTM,MGAT4C,ARAP2,SLC1A2,LIFR,DST,ADCY2,ERBB4,TNRC6A,GFAP,DTNA,MACF1,PPP2R2B,ABR,CDH20,RYR3,WDR49,PCDH9,LSAMP,DCLK1,CTNND2,FMN2,PITPNC1,RPS6KA2,AQP4,SOX5,IQCA1,CAMK2G,MSI2,PRKG1,NRG3,SLC14A1,NAV2,HIF3A,SLC25A18,GLIS3,QKI,SLC39A11,RFX4,DCLK2
5.775e-03	-5.15	YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)	protein interactions	10971	1076	8	19454	50	DCLK2,DST,SORBS1,TTN,NAV2,DCLK1,ARAP2,MACF1
5.776e-03	-5.15	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	39	16828	49	DCLK2,RYR3,WDR49,RFX4,PPP2R2B,GLIS3,ABR,CDH20,SLC25A18,MACF1,NAV2,HIF3A,PRKG1,NRG3,GFAP,DTNA,DST,ERBB4,ADCY2,TNRC6A,LIFR,SOX5,SLC1A2,IQCA1,ARAP2,MGAT4C,PITPNC1,HPSE2,FMN2,CTNND2,NTM,TRPS1,TRPM3,SORBS1,NPAS3,PCDH9,BMPR1B,DCLK1,LSAMP
5.776e-03	-5.15	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	39	16828	49	SLC25A18,CDH20,ABR,GLIS3,PPP2R2B,RFX4,RYR3,WDR49,DCLK2,IQCA1,SLC1A2,SOX5,LIFR,TNRC6A,ADCY2,ERBB4,DST,NRG3,GFAP,DTNA,PRKG1,HIF3A,NAV2,MACF1,PITPNC1,MGAT4C,ARAP2,LSAMP,DCLK1,BMPR1B,NPAS3,PCDH9,TRPM3,SORBS1,TRPS1,NTM,CTNND2,FMN2,HPSE2
5.784e-03	-5.15	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	18	16828	49	ADCY2,ERBB4,TRPM3,DCLK1,PCDH9,LIFR,CTNND2,FMN2,DAAM2,NAV2,MACF1,NRG3,MGAT4C,GLIS3,PITPNC1,RPS6KA2,RFX4,WDR49
5.793e-03	-5.15	Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME pathways	R-HSA-2730905	131	3	10285	29	ERBB4,TNRC6A,NRG3
5.875e-03	-5.14	bone	COSMIC cancer mutations	bone	8157	33	16828	49	ARAP2,PTGDS,DAAM2,HPSE2,CTNND2,FMN2,TRPS1,TRPM3,SORBS1,PCDH9,NPAS3,LSAMP,DCLK1,DCLK2,SLC39A11,RYR3,GLIS3,QKI,PPP2R2B,ABR,NAV2,MACF1,HIF3A,PRKG1,NRG3,DTNA,DST,ERBB4,TNRC6A,ADCY2,CAMK2G,SOX5,LIFR
5.880e-03	-5.14	Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME pathways	R-HSA-442755	41	2	10285	29	RPS6KA2,CAMK2G
5.885e-03	-5.14	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	4	16828	49	GLIS3,MACF1,MGAT4C,NAV2
5.908e-03	-5.13	signal transduction	biological process	GO:0007165	4637	21	18204	49	PITPNC1,BMPR1B,RYR3,TTN,SORBS1,DTNA,RPS6KA2,DAAM2,PRKG1,DCLK1,CTNND2,DCLK2,ADCY2,NRG3,ARAP2,ABR,MACF1,DST,LIFR,ERBB4,FMN2
5.952e-03	-5.12	actin filament-based process	biological process	GO:0030029	616	6	18204	49	SORBS1,TTN,QKI,FMN2,PRKG1,DAAM2
5.974e-03	-5.12	cell-substrate junction organization	biological process	GO:0150115	43	2	18204	49	DST,SORBS1
5.994e-03	-5.12	I band	cellular component	GO:0031674	144	3	19108	49	TTN,RYR3,DST
6.032e-03	-5.11	intracellular signal transduction	biological process	GO:0035556	1505	10	18204	49	TTN,RPS6KA2,FMN2,DCLK1,PRKG1,NRG3,ADCY2,DCLK2,RYR3,ABR
6.037e-03	-5.11	Calml3 (calmodulin-like 3)	protein interactions	70405	144	3	19454	50	MACF1,CAMK2G,DST
6.126e-03	-5.10	neuron projection	cellular component	GO:0043005	1331	9	19108	49	ABR,DTNA,DST,SLC1A2,PCDH9,BMPR1B,CAMK2G,CTNND2,ADCY2
6.220e-03	-5.08	DCTN1 (dynactin subunit 1)	protein interactions	1639	457	5	19454	50	MACF1,DST,TTN,DCLK2,DCLK1
6.224e-03	-5.08	cellular component organization	biological process	GO:0016043	5636	24	18204	49	CDH20,SORBS1,RYR3,AQP4,HPSE2,GFAP,FMN2,DCLK2,CTNND2,TTN,SLC1A2,TRPM3,RFX4,IQCA1,BMPR1B,PITPNC1,ERBB4,NAV2,NRG3,DST,MACF1,DAAM2,DCLK1,PRKG1
6.234e-03	-5.08	CLIP4 (CAP-Gly domain containing linker protein family member 4)	protein interactions	79745	46	2	19454	50	TTN,DST
6.247e-03	-5.08	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	49	SLC1A2,SORBS1
6.272e-03	-5.07	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	4	19454	50	DTNA,DST,SORBS1,TTN
6.288e-03	-5.07	basal plasma membrane	cellular component	GO:0009925	288	4	19108	49	ERBB4,DST,AQP4,SLC14A1
6.348e-03	-5.06	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	4	19454	50	SORBS1,TNRC6A,FMN2,PRKG1
6.384e-03	-5.05	parotid	COSMIC cancer mutations	parotid	578	6	16828	49	CAMK2G,ERBB4,RPS6KA2,DCLK1,RYR3,LIFR
6.453e-03	-5.04	Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME pathways	R-HSA-432040	43	2	10285	29	ADCY2,AQP4
6.486e-03	-5.04	-	gene3d domains	6.20.350.10	2	1	14470	47	RYR3
6.486e-03	-5.04	Bcr-Abl oncoprotein oligomerisation domain	gene3d domains	4.10.280.30	2	1	14470	47	ABR
6.495e-03	-5.04	FORMIN	prints domains	PR00828	2	1	5227	17	FMN2
6.495e-03	-5.04	CGMPKINASE	prints domains	PR00104	2	1	5227	17	PRKG1
6.500e-03	-5.04	PTGER4 (prostaglandin E receptor 4)	protein interactions	5734	47	2	19454	50	DST,CTNND2
6.527e-03	-5.03	acidic amino acid transport	biological process	GO:0015800	45	2	18204	49	SLC25A18,SLC1A2
6.599e-03	-5.02	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	9	19454	50	MACF1,TRPS1,QKI,TNRC6A,LSAMP,NAV2,GLIS3,MSI2,SOX5
6.812e-03	-4.99	regulation of oligodendrocyte differentiation	biological process	GO:0048713	46	2	18204	49	DAAM2,QKI
6.870e-03	-4.98	uveal_tract	COSMIC cancer mutations	uveal_tract	587	6	16828	49	CTNND2,MACF1,ADCY2,TNRC6A,TRPM3,PCDH9
6.881e-03	-4.98	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	3	19454	50	DST,MACF1,PRKG1
6.939e-03	-4.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	8	16828	49	PRKG1,NRG3,HPSE2,CTNND2,PCDH9,SOX5,LSAMP,ADCY2
7.049e-03	-4.95	FBLIM1 (filamin binding LIM protein 1)	protein interactions	54751	49	2	19454	50	DCLK2,DCLK1
7.119e-03	-4.94	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	4	16828	49	SOX5,SLC1A2,WDR49,RYR3
7.404e-03	-4.91	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	4	16828	49	CDH20,SOX5,RYR3,LIFR
7.446e-03	-4.90	PAS domain	gene3d domains	3.30.450.20	40	2	14470	47	HIF3A,NPAS3
7.585e-03	-4.88	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	18	16828	49	RYR3,DCLK2,DPP10,NPAS3,LIFR,PCDH9,ADCY2,TNRC6A,ERBB4,DST,TRPM3,PRKG1,CTNND2,FMN2,DAAM2,NAV2,MACF1,HPSE2
7.592e-03	-4.88	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	49	MGAT4C,MACF1
7.592e-03	-4.88	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	49	MACF1,MGAT4C
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.691e-03	-4.87	Lrrc7 (leucine rich repeat containing 7)	protein interactions	117284	3	1	19454	50	CAMK2G
7.691e-03	-4.87	NRG3 (neuregulin 3)	protein interactions	10718	3	1	19454	50	ERBB4
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	EBLN1 (endogenous Bornavirus like nucleoprotein 1)	protein interactions	340900	3	1	19454	50	TTN
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Hk2 (hexokinase 2)	protein interactions	25059	3	1	19454	50	PTGDS
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.700e-03	-4.87	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	3	16828	49	QKI,PRKG1,NRG3
7.720e-03	-4.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	10	16828	49	TRPS1,RYR3,WDR49,CTNND2,FMN2,LSAMP,DST,SORBS1,TRPM3,ARAP2
7.736e-03	-4.86	neuron differentiation	biological process	GO:0030182	1081	8	18204	49	DCLK2,NTM,BMPR1B,PRKG1,CTNND2,DCLK1,ERBB4,GFAP
7.742e-03	-4.86	neuron development	biological process	GO:0048666	859	7	18204	49	BMPR1B,CTNND2,DCLK1,PRKG1,NTM,DCLK2,GFAP
7.749e-03	-4.86	purine ribonucleoside triphosphate binding	molecular function	GO:0035639	1804	11	18094	49	IQCA1,TTN,ERBB4,BMPR1B,NAV2,CAMK2G,DCLK2,ADCY2,PRKG1,RPS6KA2,DCLK1
7.815e-03	-4.85	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME pathways	R-HSA-112314	146	3	10285	29	ADCY2,RPS6KA2,CAMK2G
7.847e-03	-4.85	basal part of cell	cellular component	GO:0045178	307	4	19108	49	SLC14A1,DST,AQP4,ERBB4
7.903e-03	-4.84	RR_TM4-6	pfam domains	PF06459	3	1	17795	47	RYR3
7.903e-03	-4.84	TM_ErbB1	pfam domains	PF21314	3	1	17795	47	ERBB4
7.903e-03	-4.84	Ago_hook	pfam domains	PF10427	3	1	17795	47	TNRC6A
7.903e-03	-4.84	Sorb	pfam domains	PF02208	3	1	17795	47	SORBS1
7.903e-03	-4.84	RyR	pfam domains	PF02026	3	1	17795	47	RYR3
7.903e-03	-4.84	TNRC6-PABC_bdg	pfam domains	PF16608	3	1	17795	47	TNRC6A
7.903e-03	-4.84	HIF-1	pfam domains	PF11413	3	1	17795	47	HIF3A
7.903e-03	-4.84	RYDR_Jsol	pfam domains	PF21119	3	1	17795	47	RYR3
7.909e-03	-4.84	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	50	SORBS1,ERBB4
7.909e-03	-4.84	AMHR2 (anti-Mullerian hormone receptor type 2)	protein interactions	269	52	2	19454	50	RPS6KA2,BMPR1B
7.916e-03	-4.84	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	49	RYR3
7.916e-03	-4.84	Neuregulin	interpro domains	IPR040180	3	1	18521	49	NRG3
7.916e-03	-4.84	Ryan_recept	interpro domains	IPR013333	3	1	18521	49	RYR3
7.916e-03	-4.84	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	49	RYR3
7.916e-03	-4.84	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	49	RYR3
7.916e-03	-4.84	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	49	RYR3
7.916e-03	-4.84	TM_ErbB1	interpro domains	IPR049328	3	1	18521	49	ERBB4
7.916e-03	-4.84	RhoGAP_ARAP	interpro domains	IPR037858	3	1	18521	49	ARAP2
7.916e-03	-4.84	SoHo_dom	interpro domains	IPR003127	3	1	18521	49	SORBS1
7.916e-03	-4.84	TNRC6_PABC-bd	interpro domains	IPR032226	3	1	18521	49	TNRC6A
7.916e-03	-4.84	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	49	HIF3A
7.916e-03	-4.84	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	49	RYR3
7.916e-03	-4.84	Argonaute_hook_dom	interpro domains	IPR019486	3	1	18521	49	TNRC6A
7.916e-03	-4.84	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	49	RYR3
7.916e-03	-4.84	Nav/unc-53	interpro domains	IPR039041	3	1	18521	49	NAV2
7.928e-03	-4.84	DTNBP1 (dystrobrevin binding protein 1)	protein interactions	84062	159	3	19454	50	MACF1,DTNA,DST
7.984e-03	-4.83	eye	COSMIC cancer mutations	eye	606	6	16828	49	TNRC6A,ADCY2,TRPM3,PCDH9,CTNND2,MACF1
8.021e-03	-4.83	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	8	19454	50	MACF1,DCLK1,NAV2,ARAP2,SORBS1,CAMK2G,DST,PITPNC1
8.054e-03	-4.82	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	49	SLC1A2
8.054e-03	-4.82	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	49	FMN2
8.054e-03	-4.82	mammary placode formation	biological process	GO:0060596	3	1	18204	49	NRG3
8.054e-03	-4.82	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	49	FMN2
8.054e-03	-4.82	striated muscle myosin thick filament assembly	biological process	GO:0071688	3	1	18204	49	TTN
8.054e-03	-4.82	vagus nerve development	biological process	GO:0021564	3	1	18204	49	NAV2
8.054e-03	-4.82	cysteine transport	biological process	GO:0042883	3	1	18204	49	SLC1A2
8.054e-03	-4.82	positive regulation of Schwann cell proliferation	biological process	GO:0010625	3	1	18204	49	GFAP
8.054e-03	-4.82	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	49	FMN2
8.054e-03	-4.82	central nervous system morphogenesis	biological process	GO:0021551	3	1	18204	49	ERBB4
8.054e-03	-4.82	skeletal muscle myosin thick filament assembly	biological process	GO:0030241	3	1	18204	49	TTN
8.054e-03	-4.82	Schwann cell proliferation	biological process	GO:0014010	3	1	18204	49	GFAP
8.054e-03	-4.82	sarcomerogenesis	biological process	GO:0048769	3	1	18204	49	TTN
8.103e-03	-4.82	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular function	GO:0008454	3	1	18094	49	MGAT4C
8.103e-03	-4.82	prostaglandin-D synthase activity	molecular function	GO:0004667	3	1	18094	49	PTGDS
8.103e-03	-4.82	oncostatin-M receptor activity	molecular function	GO:0004924	3	1	18094	49	LIFR
8.103e-03	-4.82	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	49	SLC1A2
8.103e-03	-4.82	urea channel activity	molecular function	GO:0015265	3	1	18094	49	SLC14A1
8.103e-03	-4.82	neuregulin receptor activity	molecular function	GO:0038131	3	1	18094	49	ERBB4
8.103e-03	-4.82	epidermal growth factor receptor activity	molecular function	GO:0005006	3	1	18094	49	ERBB4
8.267e-03	-4.80	muscle system process	biological process	GO:0003012	297	4	18204	49	RYR3,DTNA,PRKG1,TTN
8.343e-03	-4.79	DSCAM (DS cell adhesion molecule)	protein interactions	1826	162	3	19454	50	MACF1,DST,GFAP
8.434e-03	-4.78	MAPK family signaling cascades	REACTOME pathways	R-HSA-5683057	290	4	10285	29	ERBB4,CAMK2G,NRG3,TNRC6A
8.523e-03	-4.77	YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)	protein interactions	7531	1150	8	19454	50	DCLK2,CAMK2G,DST,SORBS1,DCLK1,NAV2,ARAP2,MACF1
8.604e-03	-4.76	cell motility	biological process	GO:0048870	1101	8	18204	49	CDH20,ERBB4,FMN2,NRG3,DST,DAAM2,DCLK1,PRKG1
8.986e-03	-4.71	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	2	10285	29	NRG3,ERBB4
9.212e-03	-4.69	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	45	16828	49	CTNND2,FMN2,LSAMP,DCLK1,PCDH9,AQP4,RPS6KA2,NRG3,PRKG1,HIF3A,NAV2,IQCA1,SOX5,CAMK2G,RFX4,SLC39A11,DCLK2,SLC25A18,GLIS3,QKI,TRPS1,NTM,DAAM2,PTGDS,HPSE2,DPP10,BMPR1B,NPAS3,SORBS1,TRPM3,MGAT4C,ARAP2,GFAP,MACF1,SLC1A2,LIFR,TNRC6A,ADCY2,ERBB4,DST,RYR3,WDR49,ABR,CDH20,PPP2R2B
9.231e-03	-4.69	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	4	19454	50	SORBS1,TTN,DTNA,MACF1
9.268e-03	-4.68	Adrenergic signaling in cardiomyocytes	KEGG pathways	ko04261	144	3	7161	22	ADCY2,CAMK2G,PPP2R2B
9.268e-03	-4.68	Adrenergic signaling in cardiomyocytes	KEGG pathways	hsa04261	144	3	7161	22	PPP2R2B,CAMK2G,ADCY2
9.312e-03	-4.68	AGC-kinase_C	interpro domains	IPR000961	55	2	18521	49	RPS6KA2,PRKG1
9.329e-03	-4.67	Aquaporin-mediated transport	REACTOME pathways	R-HSA-445717	52	2	10285	29	AQP4,ADCY2
9.361e-03	-4.67	PIAS2 (protein inhibitor of activated STAT 2)	protein interactions	9063	169	3	19454	50	NAV2,SOX5,GFAP
9.564e-03	-4.65	side of membrane	cellular component	GO:0098552	715	6	19108	49	DTNA,LSAMP,LIFR,NTM,AQP4,GFAP
9.713e-03	-4.63	-	gene3d domains	1.10.490.160	3	1	14470	47	RYR3
9.727e-03	-4.63	PGNDSYNTHASE	prints domains	PR01254	3	1	5227	17	PTGDS
9.727e-03	-4.63	RYANODINER	prints domains	PR00795	3	1	5227	17	RYR3
9.763e-03	-4.63	CILK1 (ciliogenesis associated kinase 1)	protein interactions	22858	58	2	19454	50	CAMK2G,MSI2
9.816e-03	-4.62	SOHO	prosite domains	PS50831	3	1	12186	40	SORBS1
9.929e-03	-4.61	import across plasma membrane	biological process	GO:0098739	165	3	18204	49	SLC1A2,GFAP,SLC39A11
9.962e-03	-4.61	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	4	16828	49	SLC1A2,PRKG1,GFAP,NRG3
9.962e-03	-4.61	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	4	16828	49	NRG3,GFAP,PRKG1,SLC1A2
1.009e-02	-4.60	ADAM17 (ADAM metallopeptidase domain 17)	protein interactions	6868	59	2	19454	50	ERBB4,CAMK2G
1.010e-02	-4.59	purine ribonucleotide binding	molecular function	GO:0032555	1871	11	18094	49	BMPR1B,NAV2,IQCA1,CAMK2G,DCLK2,PRKG1,ADCY2,TTN,RPS6KA2,ERBB4,DCLK1
1.023e-02	-4.58	MAPT (microtubule associated protein tau)	protein interactions	4137	948	7	19454	50	PPP2R2B,LSAMP,NTM,CTNND2,DCLK1,SORBS1,SLC1A2
1.024e-02	-4.58	Ubr5 (ubiquitin protein ligase E3 component n-recognin 5)	protein interactions	117060	4	1	19454	50	TNRC6A
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	CALML4 (calmodulin like 4)	protein interactions	91860	4	1	19454	50	CAMK2G
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	IER5L (immediate early response 5 like)	protein interactions	389792	4	1	19454	50	PPP2R2B
1.026e-02	-4.58	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	27	16828	49	PRKG1,NRG3,MACF1,NAV2,LIFR,SOX5,IQCA1,DST,CAMK2G,ADCY2,ERBB4,TNRC6A,RYR3,RFX4,DCLK2,ABR,HPSE2,FMN2,NTM,CTNND2,DPP10,BMPR1B,DCLK1,TRPM3,RPS6KA2,PITPNC1,ARAP2
1.026e-02	-4.58	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	27	16828	49	NAV2,MACF1,PRKG1,NRG3,DST,TNRC6A,ERBB4,ADCY2,CAMK2G,SOX5,LIFR,IQCA1,DCLK2,RYR3,RFX4,ABR,HPSE2,NTM,CTNND2,FMN2,TRPM3,DPP10,BMPR1B,DCLK1,RPS6KA2,ARAP2,PITPNC1
1.032e-02	-4.57	cellular component organization or biogenesis	biological process	GO:0071840	5850	24	18204	49	TTN,BMPR1B,PITPNC1,RFX4,SLC1A2,TRPM3,IQCA1,NAV2,ERBB4,DAAM2,PRKG1,DCLK1,NRG3,MACF1,DST,SORBS1,CDH20,AQP4,RYR3,HPSE2,FMN2,GFAP,CTNND2,DCLK2
1.046e-02	-4.56	Sorb	smart domains	SM00459	3	1	9717	34	SORBS1
1.052e-02	-4.55	TRPM_tetra	pfam domains	PF16519	4	1	17795	47	TRPM3
1.052e-02	-4.55	CaMKII_AD	pfam domains	PF08332	4	1	17795	47	CAMK2G
1.052e-02	-4.55	Glyco_transf_54	pfam domains	PF04666	4	1	17795	47	MGAT4C
1.054e-02	-4.55	PP2A_PR55	interpro domains	IPR000009	4	1	18521	49	PPP2R2B
1.054e-02	-4.55	RSK_N	interpro domains	IPR041906	4	1	18521	49	RPS6KA2
1.054e-02	-4.55	PP2A_PR55_CS	interpro domains	IPR018067	4	1	18521	49	PPP2R2B
1.054e-02	-4.55	TRPM_tetra	interpro domains	IPR032415	4	1	18521	49	TRPM3
1.054e-02	-4.55	Tyr_kinase_EGF/ERB/XmrK_rcpt	interpro domains	IPR016245	4	1	18521	49	ERBB4
1.054e-02	-4.55	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	49	TRPM3
1.054e-02	-4.55	Ca/CaM-dep_prot_kinase-assoc	interpro domains	IPR013543	4	1	18521	49	CAMK2G
1.054e-02	-4.55	Glyco_transf_54	interpro domains	IPR006759	4	1	18521	49	MGAT4C
1.072e-02	-4.54	leukemia inhibitory factor signaling pathway	biological process	GO:0048861	4	1	18204	49	LIFR
1.072e-02	-4.54	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	49	BMPR1B
1.072e-02	-4.54	myosin filament assembly	biological process	GO:0031034	4	1	18204	49	TTN
1.072e-02	-4.54	malate-aspartate shuttle	biological process	GO:0043490	4	1	18204	49	SLC25A18
1.072e-02	-4.54	regulation of systemic arterial blood pressure by baroreceptor feedback	biological process	GO:0003025	4	1	18204	49	NAV2
1.072e-02	-4.54	negative regulation of germ cell proliferation	biological process	GO:1905937	4	1	18204	49	PTGDS
1.072e-02	-4.54	cardiac muscle tissue regeneration	biological process	GO:0061026	4	1	18204	49	ERBB4
1.072e-02	-4.54	oncostatin-M-mediated signaling pathway	biological process	GO:0038165	4	1	18204	49	LIFR
1.072e-02	-4.54	negative regulation of male germ cell proliferation	biological process	GO:2000255	4	1	18204	49	PTGDS
1.072e-02	-4.54	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	49	SOX5
1.074e-02	-4.53	Oxytocin signaling pathway	KEGG pathways	ko04921	152	3	7161	22	CAMK2G,ADCY2,RYR3
1.074e-02	-4.53	Oxytocin signaling pathway	KEGG pathways	hsa04921	152	3	7161	22	RYR3,CAMK2G,ADCY2
1.076e-02	-4.53	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	2	10285	29	RYR3,CAMK2G
1.077e-02	-4.53	transport	biological process	GO:0006810	3615	17	18204	49	SLC39A11,PTGDS,GFAP,FMN2,ERBB4,DCLK1,SLC25A18,DST,MACF1,QKI,SLC14A1,PITPNC1,AQP4,CAMK2G,RYR3,SLC1A2,TRPM3
1.078e-02	-4.53	ribonucleotide binding	molecular function	GO:0032553	1888	11	18094	49	ERBB4,TTN,IQCA1,DCLK1,RPS6KA2,ADCY2,PRKG1,DCLK2,CAMK2G,BMPR1B,NAV2
1.079e-02	-4.53	ciliary neurotrophic factor receptor activity	molecular function	GO:0004897	4	1	18094	49	LIFR
1.079e-02	-4.53	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	49	RYR3
1.095e-02	-4.51	tat (Tat)	protein interactions	155871	1718	10	19454	50	PRKG1,RYR3,SLC14A1,SLC1A2,BMPR1B,SORBS1,PPP2R2B,CAMK2G,GFAP,ADCY2
1.098e-02	-4.51	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	6	16828	49	PRKG1,MACF1,DCLK1,DST,TRPM3,QKI
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	NRG3,PRKG1,MSI2,HIF3A,NAV2,SLC14A1,IQCA1,SOX5,CAMK2G,RFX4,SLC39A11,DCLK2,SLC25A18,GLIS3,QKI,CTNND2,FMN2,LSAMP,DCLK1,PCDH9,AQP4,RPS6KA2,PITPNC1,GFAP,DTNA,MACF1,SLC1A2,LIFR,ADCY2,ERBB4,TNRC6A,DST,RYR3,WDR49,ABR,CDH20,PPP2R2B,TRPS1,NTM,DAAM2,PTGDS,HPSE2,BMPR1B,DPP10,NPAS3,TRPM3,SORBS1,MGAT4C,ARAP2
1.100e-02	-4.51	PHF21A (PHD finger protein 21A)	protein interactions	51317	338	4	19454	50	TRPS1,TNRC6A,CAMK2G,DST
1.104e-02	-4.51	EZR (ezrin)	protein interactions	7430	526	5	19454	50	DTNA,DST,MACF1,SORBS1,ABR
1.108e-02	-4.50	protein phosphorylation	biological process	GO:0006468	503	5	18204	49	ERBB4,RPS6KA2,PRKG1,DCLK1,BMPR1B
1.110e-02	-4.50	ZKSCAN1 (zinc finger with KRAB and SCAN domains 1)	protein interactions	7586	62	2	19454	50	QKI,PRKG1
1.113e-02	-4.50	cell migration	biological process	GO:0016477	921	7	18204	49	DCLK1,PRKG1,DAAM2,FMN2,ERBB4,NRG3,CDH20
1.118e-02	-4.49	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	49	TRPS1,RYR3,PRKG1,MACF1
1.123e-02	-4.49	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	1	10285	29	SLC1A2
1.123e-02	-4.49	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	1	10285	29	SLC1A2
1.137e-02	-4.48	regulation of glucose import	biological process	GO:0046324	60	2	18204	49	SLC1A2,SORBS1
1.137e-02	-4.48	protein homotetramerization	biological process	GO:0051289	60	2	18204	49	RYR3,AQP4
1.138e-02	-4.48	head_neck	COSMIC cancer mutations	head_neck	15361	49	16828	49	PPP2R2B,CDH20,ABR,RYR3,WDR49,LIFR,SLC1A2,DST,TNRC6A,ERBB4,ADCY2,DTNA,GFAP,MACF1,ARAP2,MGAT4C,NPAS3,DPP10,BMPR1B,TRPM3,SORBS1,TRPS1,HPSE2,PTGDS,DAAM2,NTM,SLC25A18,GLIS3,QKI,SLC39A11,RFX4,DCLK2,SOX5,IQCA1,CAMK2G,MSI2,PRKG1,NRG3,NAV2,SLC14A1,HIF3A,PITPNC1,RPS6KA2,AQP4,PCDH9,DCLK1,LSAMP,FMN2,CTNND2
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.156e-02	-4.46	EF-hand	gene3d domains	1.10.238.10	272	4	14470	47	DST,DTNA,RYR3,MACF1
1.156e-02	-4.46	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	4	16828	49	MGAT4C,NAV2,MACF1,GLIS3
1.160e-02	-4.46	synapse	cellular component	GO:0045202	1473	9	19108	49	DCLK1,SLC1A2,DTNA,ABR,RPS6KA2,QKI,NRG3,ERBB4,CTNND2
1.161e-02	-4.46	QKI (QKI, KH domain containing RNA binding)	protein interactions	9444	183	3	19454	50	TNRC6A,QKI,MSI2
1.171e-02	-4.45	Regulation of lipolysis in adipocytes	KEGG pathways	hsa04923	54	2	7161	22	PRKG1,ADCY2
1.179e-02	-4.44	SYNC (syncoilin, intermediate filament protein)	protein interactions	81493	64	2	19454	50	GFAP,DTNA
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	DST,TRPS1
1.179e-02	-4.44	EVA1C (eva-1 homolog C)	protein interactions	59271	64	2	19454	50	BMPR1B,PCDH9
1.182e-02	-4.44	central nervous system neuron differentiation	biological process	GO:0021953	176	3	18204	49	DCLK2,DCLK1,BMPR1B
1.188e-02	-4.43	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	47	16828	49	SOX5,IQCA1,CAMK2G,PRKG1,NRG3,SLC14A1,NAV2,HIF3A,SLC25A18,GLIS3,QKI,SLC39A11,RFX4,DCLK2,PCDH9,LSAMP,DCLK1,CTNND2,FMN2,PITPNC1,RPS6KA2,AQP4,SLC1A2,LIFR,DST,ERBB4,ADCY2,TNRC6A,GFAP,DTNA,MACF1,PPP2R2B,CDH20,ABR,WDR49,RYR3,DPP10,BMPR1B,NPAS3,SORBS1,TRPM3,TRPS1,DAAM2,HPSE2,NTM,MGAT4C,ARAP2
1.209e-02	-4.42	kidney	COSMIC cancer mutations	kidney	15380	49	16828	49	SOX5,IQCA1,CAMK2G,PRKG1,MSI2,NRG3,SLC14A1,NAV2,HIF3A,SLC25A18,QKI,GLIS3,SLC39A11,RFX4,DCLK2,PCDH9,LSAMP,DCLK1,FMN2,CTNND2,PITPNC1,RPS6KA2,AQP4,LIFR,SLC1A2,DST,TNRC6A,ERBB4,ADCY2,DTNA,GFAP,MACF1,PPP2R2B,ABR,CDH20,WDR49,RYR3,NPAS3,BMPR1B,DPP10,TRPM3,SORBS1,TRPS1,HPSE2,DAAM2,PTGDS,NTM,ARAP2,MGAT4C
1.211e-02	-4.41	positive regulation of protein localization to plasma membrane	biological process	GO:1903078	62	2	18204	49	DPP10,SORBS1
1.223e-02	-4.40	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	10	16828	49	ERBB4,ADCY2,TNRC6A,TRPM3,NRG3,PRKG1,RYR3,HPSE2,DAAM2,NAV2
1.228e-02	-4.40	Signaling by BRAF and RAF fusions	REACTOME pathways	R-HSA-6802952	60	2	10285	29	MACF1,QKI
1.239e-02	-4.39	adherens junction	cellular component	GO:0005912	188	3	19108	49	CDH20,SORBS1,CTNND2
1.250e-02	-4.38	cell adhesion	biological process	GO:0007155	942	7	18204	49	CDH20,SORBS1,NTM,PCDH9,LSAMP,DST,CTNND2
1.261e-02	-4.37	CDH1 (cadherin 1)	protein interactions	999	757	6	19454	50	DST,MACF1,CTNND2,NAV2,SORBS1,TTN
1.261e-02	-4.37	S_TK_X	smart domains	SM00133	49	2	9717	34	RPS6KA2,PRKG1
1.262e-02	-4.37	bone-pelvis-chondrosarcoma	COSMIC cancer mutations	bone-pelvis-chondrosarcoma	311	4	16828	49	DCLK1,LSAMP,DAAM2,ERBB4
1.267e-02	-4.37	Ca2+ pathway	REACTOME pathways	R-HSA-4086398	61	2	10285	29	PRKG1,TNRC6A
1.276e-02	-4.36	calcium- and calmodulin-dependent protein kinase complex	cellular component	GO:0005954	5	1	19108	49	CAMK2G
1.278e-02	-4.36	RhoGAP	pfam domains	PF00620	65	2	17795	47	ARAP2,ABR
1.279e-02	-4.36	CAMK2N2 (calcium/calmodulin dependent protein kinase II inhibitor 2)	protein interactions	94032	5	1	19454	50	CAMK2G
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	GANC (glucosidase alpha, neutral C)	protein interactions	2595	5	1	19454	50	TTN
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	RVS161 (amphiphysin-like protein RVS161)	protein interactions	850367	5	1	19454	50	GFAP
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	Hk3 (hexokinase 3)	protein interactions	25060	5	1	19454	50	PTGDS
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	KY (kyphoscoliosis peptidase)	protein interactions	339855	5	1	19454	50	TTN
1.279e-02	-4.36	PTGER2 (prostaglandin E receptor 2)	protein interactions	5732	5	1	19454	50	PTGDS
1.279e-02	-4.36	NRG2 (neuregulin 2)	protein interactions	9542	5	1	19454	50	ERBB4
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	DPP10 (dipeptidyl peptidase like 10)	protein interactions	57628	5	1	19454	50	DPP10
1.279e-02	-4.36	PPP1R17 (protein phosphatase 1 regulatory subunit 17)	protein interactions	10842	5	1	19454	50	PRKG1
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.283e-02	-4.36	RhoGAP_dom	interpro domains	IPR000198	65	2	18521	49	ABR,ARAP2
1.287e-02	-4.35	dendrite morphogenesis	biological process	GO:0048813	64	2	18204	49	CTNND2,DCLK1
1.287e-02	-4.35	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	49	FMN2,SORBS1
1.293e-02	-4.35	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	47	TRPM3
1.295e-02	-4.35	PP2APR55	prints domains	PR00600	4	1	5227	17	PPP2R2B
1.298e-02	-4.34	TLE3 (TLE family member 3, transcriptional corepressor)	protein interactions	7090	355	4	19454	50	TRPS1,TNRC6A,QKI,TTN
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	PPP2R2B,CDH20,ABR,RYR3,WDR49,SLC1A2,LIFR,DST,ADCY2,ERBB4,TNRC6A,GFAP,MACF1,MGAT4C,ARAP2,BMPR1B,DPP10,NPAS3,TRPM3,SORBS1,TRPS1,DAAM2,PTGDS,HPSE2,NTM,SLC25A18,GLIS3,QKI,SLC39A11,RFX4,DCLK2,SOX5,IQCA1,CAMK2G,MSI2,PRKG1,NRG3,SLC14A1,NAV2,HIF3A,PITPNC1,RPS6KA2,AQP4,PCDH9,DCLK1,LSAMP,CTNND2,FMN2
1.307e-02	-4.34	PR55_1	prosite domains	PS01024	4	1	12186	40	PPP2R2B
1.307e-02	-4.34	PR55_2	prosite domains	PS01025	4	1	12186	40	PPP2R2B
1.314e-02	-4.33	PH_19	pfam domains	PF19057	5	1	17795	47	ABR
1.314e-02	-4.33	Protocadherin	pfam domains	PF08374	5	1	17795	47	PCDH9
1.314e-02	-4.33	IP_trans	pfam domains	PF02121	5	1	17795	47	PITPNC1
1.316e-02	-4.33	PI_transfer	interpro domains	IPR001666	5	1	18521	49	PITPNC1
1.316e-02	-4.33	Protocadherin	interpro domains	IPR013585	5	1	18521	49	PCDH9
1.316e-02	-4.33	DCX/DCDC2-like	interpro domains	IPR049626	5	1	18521	49	DCLK1
1.316e-02	-4.33	BBP-like	interpro domains	IPR045071	5	1	18521	49	QKI
1.323e-02	-4.33	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	4	19454	50	DST,RPS6KA2,MACF1,SORBS1
1.330e-02	-4.32	cellular response to stimulus	biological process	GO:0051716	6307	25	18204	49	TTN,RPS6KA2,BMPR1B,PITPNC1,SLC1A2,ERBB4,DAAM2,DCLK1,PRKG1,ADCY2,NRG3,ARAP2,DST,ABR,MACF1,SORBS1,TNRC6A,DTNA,AQP4,RYR3,LIFR,GFAP,FMN2,CTNND2,DCLK2
1.332e-02	-4.32	human chr13q21.32	chromosome location	human chr13q21.32	7	1	26134	50	PCDH9
1.339e-02	-4.31	ERBB2-ERBB4 signaling pathway	biological process	GO:0038135	5	1	18204	49	ERBB4
1.339e-02	-4.31	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	49	BMPR1B
1.339e-02	-4.31	ciliary neurotrophic factor-mediated signaling pathway	biological process	GO:0070120	5	1	18204	49	LIFR
1.339e-02	-4.31	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	49	FMN2
1.339e-02	-4.31	glossopharyngeal nerve development	biological process	GO:0021563	5	1	18204	49	NAV2
1.339e-02	-4.31	myosin filament organization	biological process	GO:0031033	5	1	18204	49	TTN
1.339e-02	-4.31	negative regulation of glutamate secretion	biological process	GO:0014050	5	1	18204	49	PRKG1
1.342e-02	-4.31	salivary_gland-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma-adenoid_cystic_carcinoma	488	5	16828	49	RYR3,PRKG1,CTNND2,MGAT4C,ARAP2
1.347e-02	-4.31	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	49	BMPR1B
1.347e-02	-4.31	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	1	18094	49	SLC1A2
1.347e-02	-4.31	glutamate:sodium symporter activity	molecular function	GO:0015501	5	1	18094	49	SLC1A2
1.359e-02	-4.30	cell development	biological process	GO:0048468	2236	12	18204	49	FMN2,ERBB4,GFAP,PRKG1,DCLK1,CTNND2,DCLK2,NTM,TTN,QKI,MSI2,BMPR1B
1.364e-02	-4.29	cardiac muscle cell development	biological process	GO:0055013	66	2	18204	49	PRKG1,TTN
1.364e-02	-4.29	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	49	SLC25A18,SLC1A2
1.364e-02	-4.29	ERBB signaling pathway	biological process	GO:0038127	66	2	18204	49	ERBB4,NRG3
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	CTNND2,FMN2,DCLK1,LSAMP,PCDH9,AQP4,RPS6KA2,NRG3,PRKG1,MSI2,HIF3A,SLC14A1,NAV2,IQCA1,SOX5,CAMK2G,RFX4,SLC39A11,DCLK2,SLC25A18,QKI,GLIS3,TRPS1,NTM,DAAM2,PTGDS,HPSE2,DPP10,BMPR1B,NPAS3,SORBS1,TRPM3,MGAT4C,ARAP2,GFAP,DTNA,MACF1,SLC1A2,LIFR,ADCY2,ERBB4,TNRC6A,DST,WDR49,RYR3,ABR,CDH20,PPP2R2B
1.380e-02	-4.28	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	49	SLC1A2,SLC25A18
1.398e-02	-4.27	AGC_KINASE_CTER	prosite domains	PS51285	55	2	12186	40	PRKG1,RPS6KA2
1.399e-02	-4.27	PTPDC1 (protein tyrosine phosphatase domain containing 1)	protein interactions	138639	70	2	19454	50	ERBB4,PPP2R2B
1.408e-02	-4.26	Signaling by SCF-KIT	REACTOME pathways	R-HSA-1433557	337	4	10285	29	TNRC6A,NRG3,CAMK2G,ERBB4
1.426e-02	-4.25	purine nucleotide binding	molecular function	GO:0017076	1964	11	18094	49	PRKG1,TTN,ADCY2,ERBB4,RPS6KA2,DCLK1,BMPR1B,NAV2,IQCA1,CAMK2G,DCLK2
1.431e-02	-4.25	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	29	NRG3,ERBB4
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	MACF1,DST
1.444e-02	-4.24	actin filament bundle organization	biological process	GO:0061572	68	2	18204	49	SORBS1,FMN2
1.455e-02	-4.23	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	4	ADCY2
1.491e-02	-4.21	DBN1 (drebrin 1)	protein interactions	1627	370	4	19454	50	SOX5,DST,PPP2R2B,CAMK2G
1.495e-02	-4.20	carbohydrate derivative binding	molecular function	GO:0097367	2251	12	18094	49	HPSE2,PRKG1,TTN,ADCY2,DCLK1,ERBB4,RPS6KA2,NAV2,BMPR1B,DCLK2,CAMK2G,IQCA1
1.503e-02	-4.20	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	38	16828	49	CDH20,PPP2R2B,GLIS3,QKI,RFX4,WDR49,RYR3,SLC39A11,CAMK2G,ERBB4,ADCY2,TNRC6A,DST,IQCA1,LIFR,SOX5,SLC1A2,HIF3A,MACF1,NAV2,SLC14A1,GFAP,NRG3,PRKG1,MSI2,ARAP2,RPS6KA2,TRPM3,DCLK1,LSAMP,NPAS3,PCDH9,DPP10,FMN2,CTNND2,NTM,HPSE2,DAAM2
1.503e-02	-4.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	38	16828	49	MSI2,PRKG1,GFAP,NRG3,SLC14A1,NAV2,MACF1,HIF3A,SLC1A2,SOX5,LIFR,IQCA1,DST,TNRC6A,ERBB4,ADCY2,CAMK2G,SLC39A11,WDR49,RYR3,RFX4,QKI,GLIS3,PPP2R2B,CDH20,DAAM2,HPSE2,NTM,CTNND2,FMN2,DPP10,PCDH9,NPAS3,DCLK1,LSAMP,TRPM3,RPS6KA2,ARAP2
1.516e-02	-4.19	Signaling by PTK6	REACTOME pathways	R-HSA-8848021	67	2	10285	29	ERBB4,NRG3
1.526e-02	-4.18	transporter activity	molecular function	GO:0005215	1211	8	18094	49	AQP4,SLC39A11,SLC14A1,SLC25A18,TRPM3,PITPNC1,RYR3,SLC1A2
1.531e-02	-4.18	RBMS1 (RNA binding motif single stranded interacting protein 1)	protein interactions	5937	203	3	19454	50	QKI,TNRC6A,MSI2
1.532e-02	-4.18	DAZ4 (deleted in azoospermia 4)	protein interactions	57135	6	1	19454	50	QKI
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	LIF (LIF interleukin 6 family cytokine)	protein interactions	3976	6	1	19454	50	LIFR
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	LBX2 (ladybird homeobox 2)	protein interactions	85474	6	1	19454	50	GFAP
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	PBP2 (Pbp2p)	protein interactions	852533	6	1	19454	50	QKI
1.532e-02	-4.18	CIBAR2 (CBY1 interacting BAR domain containing 2)	protein interactions	339145	6	1	19454	50	CAMK2G
1.532e-02	-4.18	ANKDD1A (ankyrin repeat and death domain containing 1A)	protein interactions	348094	6	1	19454	50	TTN
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	NRG4 (neuregulin 4)	protein interactions	145957	6	1	19454	50	ERBB4
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.532e-02	-4.18	TPPP3 (tubulin polymerization promoting protein family member 3)	protein interactions	51673	6	1	19454	50	PPP2R2B
1.533e-02	-4.18	protein homooligomerization	biological process	GO:0051260	194	3	18204	49	SLC1A2,RYR3,AQP4
1.546e-02	-4.17	actin cytoskeleton organization	biological process	GO:0030036	547	5	18204	49	FMN2,SORBS1,DAAM2,TTN,PRKG1
1.547e-02	-4.17	C20 prostanoid biosynthesis	BIOCYC pathways	HUMAN_PWY66-374	7	1	902	2	PTGDS
1.547e-02	-4.17	C20 prostanoid biosynthesis	BIOCYC pathways	META_PWY66-374	7	1	902	2	PTGDS
1.552e-02	-4.17	INPPL1 (inositol polyphosphate phosphatase like 1)	protein interactions	3636	204	3	19454	50	ARAP2,SORBS1,ERBB4
1.554e-02	-4.16	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	2	19454	50	MSI2,ERBB4
1.561e-02	-4.16	intermediate filament	cellular component	GO:0005882	205	3	19108	49	DST,GFAP,MACF1
1.575e-02	-4.15	GF_recep_IV	pfam domains	PF14843	6	1	17795	47	ERBB4
1.575e-02	-4.15	RYDR_ITPR	pfam domains	PF01365	6	1	17795	47	RYR3
1.575e-02	-4.15	EF-hand_3	pfam domains	PF09069	6	1	17795	47	DTNA
1.575e-02	-4.15	RIH_assoc	pfam domains	PF08454	6	1	17795	47	RYR3
1.575e-02	-4.15	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	47	ADCY2
1.575e-02	-4.15	THB	pfam domains	PF18362	6	1	17795	47	TTN
1.575e-02	-4.15	DPPIV_N	pfam domains	PF00930	6	1	17795	47	DPP10
1.575e-02	-4.15	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	47	RYR3
1.575e-02	-4.15	EF-hand_2	pfam domains	PF09068	6	1	17795	47	DTNA
1.577e-02	-4.15	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	49	ADCY2
1.577e-02	-4.15	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	49	RYR3
1.577e-02	-4.15	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	49	RYR3
1.577e-02	-4.15	Ribosomal_S6_kinase_II	interpro domains	IPR016239	6	1	18521	49	RPS6KA2
1.577e-02	-4.15	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	49	RYR3
1.577e-02	-4.15	GF_recep_IV	interpro domains	IPR032778	6	1	18521	49	ERBB4
1.577e-02	-4.15	RIH_dom	interpro domains	IPR000699	6	1	18521	49	RYR3
1.577e-02	-4.15	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	49	RYR3
1.577e-02	-4.15	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	49	DTNA
1.577e-02	-4.15	MyBP-C_THB	interpro domains	IPR040849	6	1	18521	49	TTN
1.577e-02	-4.15	Peptidase_S9B_N	interpro domains	IPR002469	6	1	18521	49	DPP10
1.577e-02	-4.15	GLI-like	interpro domains	IPR043359	6	1	18521	49	GLIS3
1.577e-02	-4.15	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	49	DTNA
1.583e-02	-4.15	Neuronal System	REACTOME pathways	R-HSA-112316	349	4	10285	29	RPS6KA2,ADCY2,CAMK2G,SLC1A2
1.594e-02	-4.14	TXNL4A (thioredoxin like 4A)	protein interactions	10907	75	2	19454	50	QKI,TNRC6A
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	DCLK2,RFX4,SLC39A11,GLIS3,QKI,SLC25A18,HIF3A,NAV2,SLC14A1,NRG3,MSI2,PRKG1,CAMK2G,IQCA1,SOX5,AQP4,RPS6KA2,FMN2,CTNND2,DCLK1,LSAMP,PCDH9,RYR3,WDR49,CDH20,ABR,PPP2R2B,MACF1,GFAP,DTNA,ERBB4,TNRC6A,ADCY2,DST,LIFR,SLC1A2,ARAP2,MGAT4C,NTM,HPSE2,DAAM2,PTGDS,TRPS1,TRPM3,SORBS1,NPAS3,DPP10,BMPR1B
1.604e-02	-4.13	intracellular water homeostasis	biological process	GO:0009992	6	1	18204	49	AQP4
1.604e-02	-4.13	fused antrum stage	biological process	GO:0048165	6	1	18204	49	BMPR1B
1.604e-02	-4.13	L-aspartate import across plasma membrane	biological process	GO:0140009	6	1	18204	49	SLC1A2
1.604e-02	-4.13	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	49	SOX5
1.604e-02	-4.13	mammary gland formation	biological process	GO:0060592	6	1	18204	49	NRG3
1.604e-02	-4.13	relaxation of vascular associated smooth muscle	biological process	GO:0060087	6	1	18204	49	PRKG1
1.604e-02	-4.13	hemidesmosome assembly	biological process	GO:0031581	6	1	18204	49	DST
1.604e-02	-4.13	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	49	FMN2
1.610e-02	-4.13	central_nervous_system-brain-glioma	COSMIC cancer mutations	central_nervous_system-brain-glioma	15470	49	16828	49	PPP2R2B,CDH20,ABR,WDR49,RYR3,LIFR,SLC1A2,DST,ADCY2,TNRC6A,ERBB4,GFAP,DTNA,MACF1,ARAP2,MGAT4C,NPAS3,BMPR1B,DPP10,TRPM3,SORBS1,TRPS1,HPSE2,DAAM2,PTGDS,NTM,SLC25A18,GLIS3,QKI,SLC39A11,RFX4,DCLK2,SOX5,IQCA1,CAMK2G,MSI2,PRKG1,NRG3,NAV2,SLC14A1,HIF3A,PITPNC1,RPS6KA2,AQP4,PCDH9,DCLK1,LSAMP,FMN2,CTNND2
1.614e-02	-4.13	-	gene3d domains	6.10.140.620	5	1	14470	47	CAMK2G
1.614e-02	-4.13	Formin, FH3 diaphanous domain	gene3d domains	1.10.238.150	5	1	14470	47	DAAM2
1.614e-02	-4.13	ciliary neurotrophic factor receptor binding	molecular function	GO:0005127	6	1	18094	49	LIFR
1.614e-02	-4.13	amino acid:proton symporter activity	molecular function	GO:0005280	6	1	18094	49	SLC25A18
1.614e-02	-4.13	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	49	RYR3
1.616e-02	-4.13	PITRANSFER	prints domains	PR00391	5	1	5227	17	PITPNC1
1.627e-02	-4.12	sarcoplasmic reticulum	cellular component	GO:0016529	76	2	19108	49	CAMK2G,RYR3
1.628e-02	-4.12	germ cell development	biological process	GO:0007281	363	4	18204	49	BMPR1B,PRKG1,FMN2,QKI
1.628e-02	-4.12	haematopoietic_and_lymphoid_tissue-soft_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-soft_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	67	2	16828	49	DST,PCDH9
1.629e-02	-4.12	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	50	TNRC6A,PRKG1,MACF1,BMPR1B
1.633e-02	-4.11	GATAD2A (GATA zinc finger domain containing 2A)	protein interactions	54815	208	3	19454	50	TRPS1,TNRC6A,SOX5
1.635e-02	-4.11	MIR200A (microRNA 200a)	protein interactions	406983	76	2	19454	50	QKI,MSI2
1.647e-02	-4.11	meninges	COSMIC cancer mutations	meninges	514	5	16828	49	SLC25A18,RYR3,FMN2,NAV2,RPS6KA2
1.647e-02	-4.11	meningioma	COSMIC cancer mutations	meningioma	514	5	16828	49	NAV2,RPS6KA2,FMN2,SLC25A18,RYR3
1.647e-02	-4.11	cytoskeletal protein binding	molecular function	GO:0008092	989	7	18094	49	FMN2,SORBS1,DCLK2,MACF1,DAAM2,TTN,DST
1.652e-02	-4.10	cardiac cell development	biological process	GO:0055006	73	2	18204	49	PRKG1,TTN
1.668e-02	-4.09	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	10	16828	49	DPP10,LIFR,SORBS1,QKI,CDH20,WDR49,DTNA,MACF1,CTNND2,FMN2
1.668e-02	-4.09	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	10	16828	49	CDH20,SORBS1,QKI,DPP10,LIFR,CTNND2,FMN2,MACF1,DTNA,WDR49
1.675e-02	-4.09	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	50	SORBS1,RPS6KA2,DST
1.680e-02	-4.09	RSK activation	REACTOME pathways	R-HSA-444257	6	1	10285	29	RPS6KA2
1.695e-02	-4.08	positive regulation of gliogenesis	biological process	GO:0014015	74	2	18204	49	GFAP,QKI
1.695e-02	-4.08	positive regulation of protein localization to cell periphery	biological process	GO:1904377	74	2	18204	49	DPP10,SORBS1
1.708e-02	-4.07	regulation of localization	biological process	GO:0032879	2028	11	18204	49	DCLK2,PRKG1,DCLK1,ERBB4,GFAP,CAMK2G,RYR3,SLC1A2,DPP10,SORBS1,TTN
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.717e-02	-4.06	MIR34C (microRNA 34c)	protein interactions	407042	78	2	19454	50	QKI,MSI2
1.717e-02	-4.06	ATOH1 (atonal bHLH transcription factor 1)	protein interactions	474	78	2	19454	50	GFAP,MACF1
1.735e-02	-4.05	cell adhesion molecule binding	molecular function	GO:0050839	560	5	18094	49	DST,GFAP,CDH20,MACF1,CTNND2
1.744e-02	-4.05	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	4	ADCY2
1.744e-02	-4.05	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	4	ADCY2
1.754e-02	-4.04	Downstream signaling events of B Cell Receptor (BCR)	REACTOME pathways	R-HSA-1168372	197	3	10285	29	ERBB4,TNRC6A,NRG3
1.759e-02	-4.04	KRTAP3-2 (keratin associated protein 3-2)	protein interactions	83897	79	2	19454	50	NTM,GFAP
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	22	CAMK2G,RPS6KA2
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	22	RPS6KA2,CAMK2G
1.767e-02	-4.04	mannosyl-glycoprotein N-acetylglucosaminyltransferases	BIOCYC pathways	META_PWY-7426	8	1	902	2	MGAT4C
1.769e-02	-4.03	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	10	16828	49	DST,TRPM3,ERBB4,NPAS3,SOX5,MACF1,HIF3A,DCLK2,PRKG1,WDR49
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Pum2 (pumilio RNA-binding family member 2)	protein interactions	80913	7	1	19454	50	QKI
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.801e-02	-4.02	MED13 (mediator complex subunit 13)	protein interactions	9969	80	2	19454	50	TNRC6A,QKI
1.825e-02	-4.00	calmodulin binding	molecular function	GO:0005516	206	3	18094	49	CAMK2G,RYR3,TTN
1.829e-02	-4.00	Oncogenic MAPK signaling	REACTOME pathways	R-HSA-6802957	74	2	10285	29	QKI,MACF1
1.835e-02	-4.00	Recep_L_domain	pfam domains	PF01030	7	1	17795	47	ERBB4
1.835e-02	-4.00	TGF_beta_GS	pfam domains	PF08515	7	1	17795	47	BMPR1B
1.835e-02	-4.00	SDF	pfam domains	PF00375	7	1	17795	47	SLC1A2
1.835e-02	-4.00	Filament_head	pfam domains	PF04732	7	1	17795	47	GFAP
1.835e-02	-4.00	Furin-like	pfam domains	PF00757	7	1	17795	47	ERBB4
1.836e-02	-4.00	sarcomere	cellular component	GO:0030017	218	3	19108	49	RYR3,TTN,DST
1.838e-02	-4.00	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	49	CTNND2
1.838e-02	-4.00	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	1	18521	49	SLC1A2
1.838e-02	-4.00	Rcpt_L-dom_sf	interpro domains	IPR036941	7	1	18521	49	ERBB4
1.838e-02	-4.00	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	1	18521	49	SLC1A2
1.838e-02	-4.00	GS_dom	interpro domains	IPR003605	7	1	18521	49	BMPR1B
1.838e-02	-4.00	Intermed_filament_DNA-bd	interpro domains	IPR006821	7	1	18521	49	GFAP
1.838e-02	-4.00	Furin-like_Cys-rich_dom	interpro domains	IPR006211	7	1	18521	49	ERBB4
1.838e-02	-4.00	Ammonium/urea_transptr	interpro domains	IPR029020	7	1	18521	49	SLC14A1
1.838e-02	-4.00	Aquaporin_transptr	interpro domains	IPR034294	7	1	18521	49	AQP4
1.838e-02	-4.00	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	1	18521	49	SLC1A2
1.838e-02	-4.00	Hematopoietin_rcpt_Gp130_CS	interpro domains	IPR003529	7	1	18521	49	LIFR
1.838e-02	-4.00	Rcpt_L-dom	interpro domains	IPR000494	7	1	18521	49	ERBB4
1.844e-02	-3.99	regulation of neurogenesis	biological process	GO:0050767	377	4	18204	49	MACF1,GFAP,QKI,DAAM2
1.866e-02	-3.98	KRT8 (keratin 8)	protein interactions	3856	396	4	19454	50	GFAP,DTNA,TNRC6A,TTN
1.867e-02	-3.98	transmembrane transport	biological process	GO:0055085	1264	8	18204	49	SLC39A11,SLC14A1,GFAP,AQP4,SLC25A18,TRPM3,SLC1A2,RYR3
1.869e-02	-3.98	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	49	RYR3
1.869e-02	-3.98	regulation of male germ cell proliferation	biological process	GO:2000254	7	1	18204	49	PTGDS
1.869e-02	-3.98	relaxation of smooth muscle	biological process	GO:0044557	7	1	18204	49	PRKG1
1.869e-02	-3.98	regulation of 3'-UTR-mediated mRNA stabilization	biological process	GO:1905868	7	1	18204	49	QKI
1.869e-02	-3.98	podocyte cell migration	biological process	GO:0090521	7	1	18204	49	DAAM2
1.869e-02	-3.98	regulation of testosterone biosynthetic process	biological process	GO:2000224	7	1	18204	49	PRKG1
1.869e-02	-3.98	detection of muscle stretch	biological process	GO:0035995	7	1	18204	49	TTN
1.869e-02	-3.98	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	49	FMN2
1.869e-02	-3.98	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	49	FMN2
1.869e-02	-3.98	skeletal muscle thin filament assembly	biological process	GO:0030240	7	1	18204	49	TTN
1.869e-02	-3.98	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	49	NRG3
1.872e-02	-3.98	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	49	SORBS1,SLC1A2
1.881e-02	-3.97	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	49	PITPNC1
1.881e-02	-3.97	copper ion transmembrane transporter activity	molecular function	GO:0005375	7	1	18094	49	SLC39A11
1.881e-02	-3.97	calcium-dependent protein serine/threonine phosphatase activity	molecular function	GO:0004723	7	1	18094	49	CAMK2G
1.881e-02	-3.97	telethonin binding	molecular function	GO:0031433	7	1	18094	49	TTN
1.881e-02	-3.97	mitogen-activated protein kinase p38 binding	molecular function	GO:0048273	7	1	18094	49	PRKG1
1.881e-02	-3.97	ribosomal protein S6 kinase activity	molecular function	GO:0004711	7	1	18094	49	RPS6KA2
1.884e-02	-3.97	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	21	ERBB4,NRG3
1.886e-02	-3.97	GSC (goosecoid homeobox)	protein interactions	145258	82	2	19454	50	TRPS1,SOX5
1.886e-02	-3.97	TNNT1 (troponin T1, slow skeletal type)	protein interactions	7138	82	2	19454	50	BMPR1B,PRKG1
1.896e-02	-3.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	29	16828	49	PCDH9,BMPR1B,DPP10,LSAMP,HPSE2,DAAM2,FMN2,CTNND2,ARAP2,MGAT4C,TNRC6A,ADCY2,ERBB4,LIFR,SLC1A2,SOX5,MACF1,NAV2,PRKG1,NRG3,PPP2R2B,GLIS3,QKI,ABR,CDH20,WDR49,RYR3,SLC39A11,RFX4
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.905e-02	-3.96	Diseases of signal transduction	REACTOME pathways	R-HSA-5663202	369	4	10285	29	NRG3,ERBB4,MACF1,QKI
1.914e-02	-3.96	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	49	NAV2,MACF1
1.917e-02	-3.95	regulation of glial cell differentiation	biological process	GO:0045685	79	2	18204	49	QKI,DAAM2
1.918e-02	-3.95	RHOGAP	prosite domains	PS50238	65	2	12186	40	ARAP2,ABR
1.922e-02	-3.95	prostate	COSMIC cancer mutations	prostate	13883	46	16828	49	RYR3,WDR49,CDH20,ABR,PPP2R2B,DTNA,GFAP,MACF1,SLC1A2,LIFR,TNRC6A,ADCY2,ERBB4,DST,MGAT4C,ARAP2,TRPS1,NTM,DAAM2,HPSE2,DPP10,BMPR1B,NPAS3,TRPM3,SORBS1,RFX4,SLC39A11,DCLK2,SLC25A18,QKI,GLIS3,NRG3,PRKG1,MSI2,HIF3A,NAV2,SLC14A1,SOX5,AQP4,RPS6KA2,PITPNC1,CTNND2,FMN2,DCLK1,LSAMP,PCDH9
1.929e-02	-3.95	localization	biological process	GO:0051179	4474	19	18204	49	DPP10,QKI,SLC14A1,SLC1A2,TRPM3,RYR3,CAMK2G,AQP4,PITPNC1,GFAP,FMN2,ERBB4,PTGDS,SLC39A11,DCLK2,DST,MACF1,SLC25A18,DCLK1
1.933e-02	-3.95	Single helix bin	gene3d domains	1.20.5.490	6	1	14470	47	PRKG1
1.933e-02	-3.95	Dipeptidylpeptidase IV, N-terminal domain	gene3d domains	2.140.10.30	6	1	14470	47	DPP10
1.933e-02	-3.95	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	47	RYR3
1.937e-02	-3.94	ACTIVIN2R	prints domains	PR00653	6	1	5227	17	BMPR1B
1.939e-02	-3.94	PSEN1 (presenilin 1)	protein interactions	5663	222	3	19454	50	DTNA,GFAP,CTNND2
1.941e-02	-3.94	Rho GTPase activation protein	gene3d domains	1.10.555.10	66	2	14470	47	ARAP2,ABR
1.956e-02	-3.93	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	4	10285	29	NRG3,TNRC6A,ERBB4,CAMK2G
1.958e-02	-3.93	CREB phosphorylation	REACTOME pathways	R-HSA-199920	7	1	10285	29	RPS6KA2
1.958e-02	-3.93	Post-transcriptional silencing by small RNAs	REACTOME pathways	R-HSA-426496	7	1	10285	29	TNRC6A
1.964e-02	-3.93	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	49	NAV2,MACF1
1.970e-02	-3.93	Bile secretion	KEGG pathways	hsa04976	71	2	7161	22	ADCY2,AQP4
1.970e-02	-3.93	Bile secretion	KEGG pathways	ko04976	71	2	7161	22	AQP4,ADCY2
1.974e-02	-3.93	PSEN2 (presenilin 2)	protein interactions	5664	84	2	19454	50	GFAP,CTNND2
1.976e-02	-3.92	AP2M1 (adaptor related protein complex 2 subunit mu 1)	protein interactions	1173	403	4	19454	50	RPS6KA2,TNRC6A,GFAP,AQP4
1.989e-02	-3.92	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	9	16828	49	ADCY2,ERBB4,TRPM3,NRG3,RYR3,PRKG1,NAV2,DAAM2,HPSE2
1.992e-02	-3.92	EF_hand_dom	interpro domains	IPR002048	218	3	18521	49	DST,MACF1,RYR3
2.018e-02	-3.90	CFAP298 (cilia and flagella associated protein 298)	protein interactions	56683	85	2	19454	50	TRPS1,FMN2
2.032e-02	-3.90	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	49	BMPR1B,ERBB4
2.032e-02	-3.90	g-Secretase Mediated ErbB4 Signalling Pathway	SMPDB pathways	SMP0089975	7	1	1369	4	ERBB4
2.032e-02	-3.90	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	4	ADCY2
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.034e-02	-3.90	hemidesmosome	cellular component	GO:0030056	8	1	19108	49	DST
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	NKAIN3 (sodium/potassium transporting ATPase interacting 3)	protein interactions	286183	8	1	19454	50	GFAP
2.038e-02	-3.89	DEPP1 (DEPP autophagy regulator 1)	protein interactions	11067	8	1	19454	50	QKI
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	Mrps31 (mitochondrial ribosomal protein S31)	protein interactions	57312	8	1	19454	50	DST
2.038e-02	-3.89	UBALD2 (UBA like domain containing 2)	protein interactions	283991	8	1	19454	50	GFAP
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	PTGER1 (prostaglandin E receptor 1)	protein interactions	5731	8	1	19454	50	PTGDS
2.039e-02	-3.89	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	9	16828	49	QKI,DST,SLC1A2,DPP10,PITPNC1,RPS6KA2,FMN2,CTNND2,RFX4
2.039e-02	-3.89	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	9	16828	49	DST,QKI,SLC1A2,PITPNC1,DPP10,CTNND2,FMN2,RPS6KA2,RFX4
2.049e-02	-3.89	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	29	CAMK2G,TRPM3,RYR3
2.053e-02	-3.89	contractile actin filament bundle	cellular component	GO:0097517	86	2	19108	49	DST,SORBS1
2.053e-02	-3.89	stress fiber	cellular component	GO:0001725	86	2	19108	49	SORBS1,DST
2.055e-02	-3.88	TOMM20 (translocase of outer mitochondrial membrane 20)	protein interactions	9804	227	3	19454	50	ABR,DST,TNRC6A
2.059e-02	-3.88	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	21	ADCY2,RYR3,CAMK2G
2.073e-02	-3.88	stomach	COSMIC cancer mutations	stomach	15550	49	16828	49	DST,TNRC6A,ERBB4,ADCY2,SLC1A2,LIFR,MACF1,DTNA,GFAP,PPP2R2B,ABR,CDH20,RYR3,WDR49,SORBS1,TRPM3,DPP10,BMPR1B,NPAS3,PTGDS,DAAM2,HPSE2,NTM,TRPS1,MGAT4C,ARAP2,CAMK2G,SOX5,IQCA1,NAV2,SLC14A1,HIF3A,PRKG1,MSI2,NRG3,QKI,GLIS3,SLC25A18,DCLK2,SLC39A11,RFX4,PCDH9,LSAMP,DCLK1,CTNND2,FMN2,PITPNC1,RPS6KA2,AQP4
2.089e-02	-3.87	SH3_domain	interpro domains	IPR001452	222	3	18521	49	MACF1,SORBS1,DST
2.092e-02	-3.87	RhoGAP	smart domains	SM00324	64	2	9717	34	ABR,ARAP2
2.092e-02	-3.87	cellular localization	biological process	GO:0051641	2660	13	18204	49	CAMK2G,SLC1A2,SLC14A1,QKI,DPP10,MACF1,DST,DCLK2,DCLK1,ERBB4,FMN2,GFAP,PTGDS
2.094e-02	-3.87	LSDAT_euk	pfam domains	PF18139	8	1	17795	47	TRPM3
2.094e-02	-3.87	AC_N	pfam domains	PF16214	8	1	17795	47	ADCY2
2.097e-02	-3.86	Adcy	interpro domains	IPR030672	8	1	18521	49	ADCY2
2.097e-02	-3.86	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	49	TRPM3
2.097e-02	-3.86	AC_N	interpro domains	IPR032628	8	1	18521	49	ADCY2
2.097e-02	-3.86	RFX-like	interpro domains	IPR039779	8	1	18521	49	RFX4
2.097e-02	-3.86	DAD_dom	interpro domains	IPR014767	8	1	18521	49	DAAM2
2.105e-02	-3.86	glutamatergic synapse	cellular component	GO:0098978	412	4	19108	49	ERBB4,SLC1A2,ABR,NRG3
2.106e-02	-3.86	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	4	16828	49	PCDH9,CTNND2,MACF1,TRPM3
2.108e-02	-3.86	FGR (FGR proto-oncogene, Src family tyrosine kinase)	protein interactions	2268	87	2	19454	50	SLC25A18,ERBB4
2.108e-02	-3.86	MIR141 (microRNA 141)	protein interactions	406933	87	2	19454	50	QKI,MSI2
2.109e-02	-3.86	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	5	18094	49	SLC39A11,RYR3,SLC1A2,SLC25A18,TRPM3
2.120e-02	-3.85	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	25	16828	49	RFX4,SLC39A11,ABR,CDH20,GLIS3,NRG3,DTNA,PRKG1,HIF3A,NAV2,MACF1,ERBB4,ADCY2,TNRC6A,CAMK2G,DST,MGAT4C,ARAP2,TRPS1,FMN2,HPSE2,DPP10,PCDH9,TRPM3,SORBS1
2.126e-02	-3.85	femur	COSMIC cancer mutations	femur	1197	8	16828	49	RYR3,SLC39A11,NRG3,HPSE2,NAV2,FMN2,PCDH9,ADCY2
2.129e-02	-3.85	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	25	16828	49	DST,CAMK2G,TNRC6A,ERBB4,ADCY2,MACF1,NAV2,HIF3A,PRKG1,NRG3,DTNA,GLIS3,ABR,CDH20,SLC39A11,RFX4,TRPM3,SORBS1,PCDH9,DPP10,HPSE2,FMN2,TRPS1,ARAP2,MGAT4C
2.134e-02	-3.85	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	49	FMN2
2.134e-02	-3.85	regulation of germ cell proliferation	biological process	GO:1905936	8	1	18204	49	PTGDS
2.134e-02	-3.85	regulation of chaperone-mediated autophagy	biological process	GO:1904714	8	1	18204	49	GFAP
2.134e-02	-3.85	copper ion transmembrane transport	biological process	GO:0035434	8	1	18204	49	SLC39A11
2.146e-02	-3.84	urea transmembrane transporter activity	molecular function	GO:0015204	8	1	18094	49	SLC14A1
2.146e-02	-3.84	cyclic nucleotide-dependent protein kinase activity	molecular function	GO:0004690	8	1	18094	49	PRKG1
2.146e-02	-3.84	BMP receptor activity	molecular function	GO:0098821	8	1	18094	49	BMPR1B
2.151e-02	-3.84	stem cell development	biological process	GO:0048864	84	2	18204	49	ERBB4,MSI2
2.151e-02	-3.84	L-amino acid transport	biological process	GO:0015807	84	2	18204	49	SLC1A2,SLC25A18
2.153e-02	-3.84	FAM241B (family with sequence similarity 241 member B)	protein interactions	219738	88	2	19454	50	SLC39A11,ERBB4
2.159e-02	-3.84	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	5	19454	50	ERBB4,SORBS1,MSI2,SLC14A1,GFAP
2.165e-02	-3.83	establishment of localization	biological process	GO:0051234	3887	17	18204	49	CAMK2G,RYR3,SLC1A2,TRPM3,AQP4,PITPNC1,SLC14A1,QKI,MACF1,DST,DCLK1,SLC25A18,FMN2,ERBB4,GFAP,SLC39A11,PTGDS
2.168e-02	-3.83	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	9	16828	49	CDH20,DST,LIFR,FMN2,CTNND2,MACF1,NAV2,RFX4,RYR3
2.168e-02	-3.83	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	9	16828	49	DST,CDH20,LIFR,MACF1,NAV2,FMN2,CTNND2,RYR3,RFX4
2.175e-02	-3.83	CDC23 (cell division cycle 23)	protein interactions	8697	232	3	19454	50	DCLK1,SOX5,TNRC6A
2.184e-02	-3.82	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	22	CAMK2G,ADCY2
2.184e-02	-3.82	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	22	ADCY2,CAMK2G
2.199e-02	-3.82	chondrocyte differentiation	biological process	GO:0002062	85	2	18204	49	BMPR1B,SOX5
2.199e-02	-3.82	MTMR6 (myotubularin related protein 6)	protein interactions	9107	89	2	19454	50	ERBB4,TTN
2.201e-02	-3.82	cellular process involved in reproduction in multicellular organism	biological process	GO:0022412	398	4	18204	49	PRKG1,BMPR1B,FMN2,QKI
2.221e-02	-3.81	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-polycythaemia_vera	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-polycythaemia_vera	369	4	16828	49	CTNND2,ARAP2,DST,DCLK1
2.221e-02	-3.81	polycythaemia_vera	COSMIC cancer mutations	polycythaemia_vera	369	4	16828	49	DCLK1,CTNND2,DST,ARAP2
2.224e-02	-3.81	EPHA1 (EPH receptor A1)	protein interactions	2041	234	3	19454	50	SLC39A11,DST,TTN
2.234e-02	-3.80	Downregulation of ERBB4 signaling	REACTOME pathways	R-HSA-1253288	8	1	10285	29	ERBB4
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	DTNA,FMN2
2.247e-02	-3.80	central nervous system neuron development	biological process	GO:0021954	86	2	18204	49	DCLK1,DCLK2
2.249e-02	-3.79	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	3	19454	50	MACF1,PPP2R2B,DTNA
2.252e-02	-3.79	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	1	14470	47	SLC1A2
2.252e-02	-3.79	Receptor L-domain	gene3d domains	3.80.20.20	7	1	14470	47	ERBB4
2.252e-02	-3.79	Ammonium transporter AmtB like domains	gene3d domains	1.10.3430.10	7	1	14470	47	SLC14A1
2.256e-02	-3.79	EDTRNSPORT	prints domains	PR00173	7	1	5227	17	SLC1A2
2.272e-02	-3.78	human chr6q26	chromosome location	human chr6q26	12	1	26134	50	QKI
2.276e-02	-3.78	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	1	12186	40	SLC1A2
2.276e-02	-3.78	GS	prosite domains	PS51256	7	1	12186	40	BMPR1B
2.276e-02	-3.78	HEMATOPO_REC_L_F2	prosite domains	PS01353	7	1	12186	40	LIFR
2.276e-02	-3.78	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	1	12186	40	SLC1A2
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.290e-02	-3.78	LSB3 (Lsb3p)	protein interactions	850580	9	1	19454	50	GFAP
2.290e-02	-3.78	Ywhag (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide)	protein interactions	22628	9	1	19454	50	QKI
2.290e-02	-3.78	MUC4 (mucin 4, cell surface associated)	protein interactions	4585	9	1	19454	50	ERBB4
2.290e-02	-3.78	ADAM2 (ADAM metallopeptidase domain 2)	protein interactions	2515	9	1	19454	50	TTN
2.290e-02	-3.78	IER5 (immediate early response 5)	protein interactions	51278	9	1	19454	50	PPP2R2B
2.290e-02	-3.78	PI3 (peptidase inhibitor 3)	protein interactions	5266	9	1	19454	50	PPP2R2B
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1)	protein interactions	55450	9	1	19454	50	CAMK2G
2.292e-02	-3.78	NEIL3 (nei like DNA glycosylase 3)	protein interactions	55247	91	2	19454	50	QKI,GFAP
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	DCLK1,NTM
2.292e-02	-3.78	PTPN21 (protein tyrosine phosphatase non-receptor type 21)	protein interactions	11099	91	2	19454	50	NRG3,ERBB4
2.292e-02	-3.78	THUMPD3 (THUMP domain containing 3)	protein interactions	25917	91	2	19454	50	CTNND2,RPS6KA2
2.299e-02	-3.77	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	3	19454	50	CAMK2G,GFAP,SOX5
2.306e-02	-3.77	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	8	1	16828	49	QKI
2.320e-02	-3.76	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	4	ADCY2
2.320e-02	-3.76	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	3	5310	21	CAMK2G,RYR3,ADCY2
2.324e-02	-3.76	Proteoglycans in cancer	KEGG pathways	hsa05205	203	3	7161	22	HPSE2,CAMK2G,ERBB4
2.324e-02	-3.76	Proteoglycans in cancer	KEGG pathways	ko05205	203	3	7161	22	CAMK2G,HPSE2,ERBB4
2.329e-02	-3.76	actomyosin	cellular component	GO:0042641	92	2	19108	49	DST,SORBS1
2.330e-02	-3.76	RNF43 (ring finger protein 43)	protein interactions	54894	424	4	19454	50	TTN,MACF1,TNRC6A,QKI
2.334e-02	-3.76	myofibril	cellular component	GO:0030016	239	3	19108	49	DST,TTN,RYR3
2.353e-02	-3.75	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	47	RFX4
2.353e-02	-3.75	Peptidase_S9	pfam domains	PF00326	9	1	17795	47	DPP10
2.353e-02	-3.75	Activin_recp	pfam domains	PF01064	9	1	17795	47	BMPR1B
2.353e-02	-3.75	Drf_GBD	pfam domains	PF06371	9	1	17795	47	DAAM2
2.353e-02	-3.75	Drf_FH3	pfam domains	PF06367	9	1	17795	47	DAAM2
2.357e-02	-3.75	Activin_recp	interpro domains	IPR000472	9	1	18521	49	BMPR1B
2.357e-02	-3.75	FH3_dom	interpro domains	IPR010472	9	1	18521	49	DAAM2
2.357e-02	-3.75	Peptidase_S9	interpro domains	IPR001375	9	1	18521	49	DPP10
2.357e-02	-3.75	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	49	RFX4
2.357e-02	-3.75	GTPase-bd	interpro domains	IPR010473	9	1	18521	49	DAAM2
2.369e-02	-3.74	Rho_GTPase_activation_prot	interpro domains	IPR008936	90	2	18521	49	ABR,ARAP2
2.385e-02	-3.74	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	8	16828	49	CTNND2,ADCY2,ERBB4,ARAP2,TRPM3,DCLK1,WDR49,DPP10
2.387e-02	-3.74	TEX11 (testis expressed 11)	protein interactions	56159	93	2	19454	50	QKI,SOX5
2.387e-02	-3.74	MIR19B2 (microRNA 19b-2)	protein interactions	406981	93	2	19454	50	MSI2,QKI
2.397e-02	-3.73	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	49	RYR3
2.397e-02	-3.73	cyclooxygenase pathway	biological process	GO:0019371	9	1	18204	49	PTGDS
2.397e-02	-3.73	zinc ion import across plasma membrane	biological process	GO:0071578	9	1	18204	49	SLC39A11
2.401e-02	-3.73	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	50	DST,CTNND2,ABR
2.412e-02	-3.72	microtubule severing ATPase activity	molecular function	GO:0008568	9	1	18094	49	IQCA1
2.412e-02	-3.72	L-aspartate transmembrane transporter activity	molecular function	GO:0015183	9	1	18094	49	SLC25A18
2.412e-02	-3.72	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	19	16828	49	ARAP2,PPP2R2B,GLIS3,CDH20,RYR3,AQP4,DPP10,NPAS3,DCLK1,SORBS1,TRPM3,TNRC6A,ADCY2,CAMK2G,TRPS1,NAV2,MACF1,CTNND2,FMN2
2.424e-02	-3.72	GS	smart domains	SM00467	7	1	9717	34	BMPR1B
2.435e-02	-3.72	TRAF3IP1 (TRAF3 interacting protein 1)	protein interactions	26146	94	2	19454	50	MACF1,DST
2.453e-02	-3.71	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	29	16828	49	ARAP2,NPAS3,DCLK1,TRPM3,SORBS1,TRPS1,DAAM2,PTGDS,FMN2,CTNND2,QKI,GLIS3,PPP2R2B,ABR,RYR3,DCLK2,LIFR,SOX5,DST,CAMK2G,ADCY2,ERBB4,TNRC6A,PRKG1,DTNA,NRG3,MACF1,NAV2,HIF3A
2.464e-02	-3.70	nucleotide binding	molecular function	GO:0000166	2128	11	18094	49	ADCY2,PRKG1,DCLK1,RPS6KA2,NAV2,BMPR1B,DCLK2,CAMK2G,TTN,ERBB4,IQCA1
2.469e-02	-3.70	neck	COSMIC cancer mutations	neck	1231	8	16828	49	DCLK1,DPP10,ERBB4,ADCY2,TRPM3,ARAP2,WDR49,CTNND2
2.472e-02	-3.70	nucleoside phosphate binding	molecular function	GO:1901265	2129	11	18094	49	CAMK2G,IQCA1,DCLK2,BMPR1B,NAV2,ERBB4,RPS6KA2,DCLK1,PRKG1,ADCY2,TTN
2.477e-02	-3.70	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	29	ERBB4,NRG3
2.495e-02	-3.69	axon	cellular component	GO:0030424	650	5	19108	49	SLC1A2,PCDH9,DST,DTNA,ABR
2.521e-02	-3.68	sarcoplasm	cellular component	GO:0016528	96	2	19108	49	CAMK2G,RYR3
2.521e-02	-3.68	actin filament bundle	cellular component	GO:0032432	96	2	19108	49	DST,SORBS1
2.529e-02	-3.68	Ig_sub2	interpro domains	IPR003598	239	3	18521	49	LSAMP,NTM,TTN
2.531e-02	-3.68	PRKD2 (protein kinase D2)	protein interactions	25865	246	3	19454	50	CAMK2G,PPP2R2B,DST
2.537e-02	-3.67	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	10	19454	50	RPS6KA2,DCLK2,MSI2,TRPS1,MACF1,NRG3,QKI,DTNA,ABR,BMPR1B
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	DEFA1B (defensin alpha 1B)	protein interactions	728358	10	1	19454	50	PPP2R2B
2.541e-02	-3.67	MYBPH (myosin binding protein H)	protein interactions	4608	10	1	19454	50	TTN
2.541e-02	-3.67	DOA4 (ubiquitin-specific protease DOA4)	protein interactions	851641	10	1	19454	50	NAV2
2.541e-02	-3.67	Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1)	protein interactions	15519	10	1	19454	50	QKI
2.541e-02	-3.67	EREG (epiregulin)	protein interactions	2069	10	1	19454	50	ERBB4
2.541e-02	-3.67	PTPRT (protein tyrosine phosphatase receptor type T)	protein interactions	11122	10	1	19454	50	ERBB4
2.541e-02	-3.67	Mrpl13 (mitochondrial ribosomal protein L13)	protein interactions	68537	10	1	19454	50	QKI
2.568e-02	-3.66	spindle	COSMIC cancer mutations	spindle	386	4	16828	49	CTNND2,MACF1,TRPM3,PCDH9
2.574e-02	-3.66	LIPOCALIN	prints domains	PR00179	8	1	5227	17	PTGDS
2.574e-02	-3.66	GATAZNFINGER	prints domains	PR00619	8	1	5227	17	TRPS1
2.580e-02	-3.66	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	2	7161	22	ADCY2,CAMK2G
2.580e-02	-3.66	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	2	7161	22	ADCY2,CAMK2G
2.581e-02	-3.66	PLCB3 (phospholipase C beta 3)	protein interactions	5331	97	2	19454	50	PRKG1,CAMK2G
2.581e-02	-3.66	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	2	19454	50	DCLK2,TNRC6A
2.585e-02	-3.66	ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)	protein interactions	25	248	3	19454	50	CTNND2,SORBS1,ERBB4
2.595e-02	-3.65	contractile muscle fiber	cellular component	GO:0043292	249	3	19108	49	DST,RYR3,TTN
2.597e-02	-3.65	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	40	TRPS1
2.597e-02	-3.65	DAD	prosite domains	PS51231	8	1	12186	40	DAAM2
2.599e-02	-3.65	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	49	NRG3,ERBB4,BMPR1B,SORBS1,LIFR
2.600e-02	-3.65	Signaling by the B Cell Receptor (BCR)	REACTOME pathways	R-HSA-983705	229	3	10285	29	NRG3,TNRC6A,ERBB4
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	4	ADCY2
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	4	ADCY2
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	4	ADCY2
2.607e-02	-3.65	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	4	ADCY2
2.607e-02	-3.65	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	4	ADCY2
2.611e-02	-3.65	PAS_3	pfam domains	PF08447	10	1	17795	47	NPAS3
2.611e-02	-3.65	MIR	pfam domains	PF02815	10	1	17795	47	RYR3
2.612e-02	-3.65	GAN (gigaxonin)	protein interactions	8139	249	3	19454	50	DST,GFAP,TTN
2.615e-02	-3.64	PAS_fold_3	interpro domains	IPR013655	10	1	18521	49	NPAS3
2.615e-02	-3.64	MIR_motif	interpro domains	IPR016093	10	1	18521	49	RYR3
2.615e-02	-3.64	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	49	RYR3
2.615e-02	-3.64	MIP_CS	interpro domains	IPR022357	10	1	18521	49	AQP4
2.616e-02	-3.64	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	49	MACF1,ERBB4,DPP10
2.616e-02	-3.64	muscle contraction	biological process	GO:0006936	238	3	18204	49	RYR3,DTNA,TTN
2.619e-02	-3.64	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	49	TTN,ERBB4
2.624e-02	-3.64	SYNE3 (spectrin repeat containing nuclear envelope family member 3)	protein interactions	161176	440	4	19454	50	SORBS1,TNRC6A,DST,MACF1
2.631e-02	-3.64	VAV2 (vav guanine nucleotide exchange factor 2)	protein interactions	7410	98	2	19454	50	TTN,ERBB4
2.631e-02	-3.64	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	2	19454	50	SORBS1,RPS6KA2
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	DCLK1,LSAMP
2.631e-02	-3.64	FRAS1 (Fraser extracellular matrix complex subunit 1)	protein interactions	80144	98	2	19454	50	MGAT4C,HPSE2
2.638e-02	-3.64	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	29	NRG3,ERBB4
2.660e-02	-3.63	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	49	NRG3
2.660e-02	-3.63	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	49	RYR3
2.660e-02	-3.63	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	49	ADCY2
2.660e-02	-3.63	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	49	SOX5
2.660e-02	-3.63	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	49	NRG3
2.660e-02	-3.63	mitochondrial fragmentation involved in apoptotic process	biological process	GO:0043653	10	1	18204	49	ERBB4
2.660e-02	-3.63	skeletal myofibril assembly	biological process	GO:0014866	10	1	18204	49	TTN
2.660e-02	-3.63	cellular response to cocaine	biological process	GO:0071314	10	1	18204	49	SLC1A2
2.660e-02	-3.63	urea transmembrane transport	biological process	GO:0071918	10	1	18204	49	SLC14A1
2.676e-02	-3.62	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	49	PITPNC1
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	SOX5,TRPS1
2.702e-02	-3.61	gallbladder	COSMIC cancer mutations	gallbladder	2821	14	16828	49	SLC39A11,RYR3,PITPNC1,CTNND2,FMN2,MACF1,NRG3,TRPS1,PRKG1,ERBB4,TRPM3,DCLK1,DPP10,PCDH9
2.702e-02	-3.61	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	14	16828	49	PCDH9,DPP10,DCLK1,TRPM3,ERBB4,PRKG1,TRPS1,NRG3,MACF1,FMN2,CTNND2,PITPNC1,RYR3,SLC39A11
2.704e-02	-3.61	cardiac muscle cell differentiation	biological process	GO:0055007	95	2	18204	49	TTN,PRKG1
2.706e-02	-3.61	peritoneum-appendix-other-pseudomyxoma_peritonei	COSMIC cancer mutations	peritoneum-appendix-other-pseudomyxoma_peritonei	585	5	16828	49	DCLK1,TRPS1,WDR49,DST,MACF1
2.706e-02	-3.61	pseudomyxoma_peritonei	COSMIC cancer mutations	pseudomyxoma_peritonei	585	5	16828	49	DCLK1,TRPS1,WDR49,DST,MACF1
2.712e-02	-3.61	EF-hand_7	pfam domains	PF13499	97	2	17795	47	DST,MACF1
2.719e-02	-3.61	extrinsic component of plasma membrane	cellular component	GO:0019897	100	2	19108	49	DTNA,CDH20
2.723e-02	-3.60	appendix	COSMIC cancer mutations	appendix	586	5	16828	49	DST,MACF1,DCLK1,TRPS1,WDR49
2.723e-02	-3.60	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	5	18094	49	SLC1A2,RYR3,SLC39A11,TRPM3,SLC25A18
2.733e-02	-3.60	Heparan sulfate degradation	KEGG pathways	hsa_M00078	9	1	7161	22	HPSE2
2.733e-02	-3.60	cGMP signaling	KEGG pathways	M00694	9	1	7161	22	PRKG1
2.733e-02	-3.60	cGMP signaling	KEGG pathways	hsa_M00694	9	1	7161	22	PRKG1
2.733e-02	-3.60	Heparan sulfate degradation	KEGG pathways	M00078	9	1	7161	22	HPSE2
2.737e-02	-3.60	pancreas-other-adenoma	COSMIC cancer mutations	pancreas-other-adenoma	224	3	16828	49	CTNND2,PCDH9,BMPR1B
2.741e-02	-3.60	peritoneum	COSMIC cancer mutations	peritoneum	587	5	16828	49	MACF1,DST,DCLK1,WDR49,TRPS1
2.748e-02	-3.59	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	29	NTM,LSAMP
2.758e-02	-3.59	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	22	ADCY2,CAMK2G
2.776e-02	-3.58	LMO2 (LIM domain only 2)	protein interactions	4005	255	3	19454	50	SOX5,PRKG1,GFAP
2.785e-02	-3.58	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	29	ADCY2
2.785e-02	-3.58	Organic anion transporters	REACTOME pathways	R-HSA-428643	10	1	10285	29	SLC25A18
2.786e-02	-3.58	interstitial matrix	cellular component	GO:0005614	11	1	19108	49	NAV2
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	DAZ1 (deleted in azoospermia 1)	protein interactions	1617	11	1	19454	50	QKI
2.792e-02	-3.58	PTGDR (prostaglandin D2 receptor)	protein interactions	5729	11	1	19454	50	PTGDS
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	PRKG1
2.792e-02	-3.58	IL7 (interleukin 7)	protein interactions	3574	11	1	19454	50	QKI
2.792e-02	-3.58	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	1	19454	50	ADCY2
2.809e-02	-3.57	cellular component assembly	biological process	GO:0022607	2472	12	18204	49	FMN2,ERBB4,NRG3,DST,TTN,SORBS1,CDH20,AQP4,RFX4,TRPM3,SLC1A2,RYR3
2.814e-02	-3.57	basolateral plasma membrane	cellular component	GO:0016323	257	3	19108	49	AQP4,ERBB4,SLC14A1
2.832e-02	-3.56	human chr18q12.3	chromosome location	human chr18q12.3	15	1	26134	50	SLC14A1
2.832e-02	-3.56	MIR7-1 (microRNA 7-1)	protein interactions	407043	102	2	19454	50	MSI2,QKI
2.832e-02	-3.56	KRTAP6-1 (keratin associated protein 6-1)	protein interactions	337966	102	2	19454	50	GLIS3,CAMK2G
2.832e-02	-3.56	GRAP2 (GRB2 related adaptor protein 2)	protein interactions	9402	102	2	19454	50	ERBB4,GFAP
2.847e-02	-3.56	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	49	MACF1,QKI,GFAP
2.859e-02	-3.55	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	29	ERBB4,NRG3
2.868e-02	-3.55	PAS_11	pfam domains	PF14598	11	1	17795	47	HIF3A
2.873e-02	-3.55	GBD/FH3_dom	interpro domains	IPR014768	11	1	18521	49	DAAM2
2.875e-02	-3.55	chiasm	COSMIC cancer mutations	chiasm	10	1	16828	49	QKI
2.875e-02	-3.55	regulation of protein localization	biological process	GO:0032880	872	6	18204	49	DPP10,ERBB4,DCLK2,DCLK1,SORBS1,TTN
2.884e-02	-3.55	ID2 (inhibitor of DNA binding 2)	protein interactions	3398	103	2	19454	50	DST,MACF1
2.891e-02	-3.54	transmembrane transporter activity	molecular function	GO:0022857	1110	7	18094	49	SLC39A11,AQP4,RYR3,SLC1A2,SLC25A18,SLC14A1,TRPM3
2.893e-02	-3.54	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	4	ADCY2
2.897e-02	-3.54	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	3	16828	49	ERBB4,CTNND2,HPSE2
2.917e-02	-3.53	RFX_DBD	prosite domains	PS51526	9	1	12186	40	RFX4
2.922e-02	-3.53	Bergmann glial cell differentiation	biological process	GO:0060020	11	1	18204	49	GFAP
2.922e-02	-3.53	ectodermal placode formation	biological process	GO:0060788	11	1	18204	49	NRG3
2.922e-02	-3.53	physiological cardiac muscle hypertrophy	biological process	GO:0003301	11	1	18204	49	PRKG1
2.922e-02	-3.53	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	49	PRKG1
2.922e-02	-3.53	L-glutamate import across plasma membrane	biological process	GO:0098712	11	1	18204	49	SLC1A2
2.922e-02	-3.53	intracellular mRNA localization	biological process	GO:0008298	11	1	18204	49	QKI
2.922e-02	-3.53	pyramidal neuron development	biological process	GO:0021860	11	1	18204	49	DCLK2
2.922e-02	-3.53	regulation of Schwann cell proliferation	biological process	GO:0010624	11	1	18204	49	GFAP
2.922e-02	-3.53	physiological muscle hypertrophy	biological process	GO:0003298	11	1	18204	49	PRKG1
2.922e-02	-3.53	cellular response to caffeine	biological process	GO:0071313	11	1	18204	49	RYR3
2.922e-02	-3.53	cell growth involved in cardiac muscle cell development	biological process	GO:0061049	11	1	18204	49	PRKG1
2.922e-02	-3.53	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	49	NRG3
2.922e-02	-3.53	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	49	NRG3
2.922e-02	-3.53	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	49	BMPR1B
2.936e-02	-3.53	ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough)	protein interactions	404734	104	2	19454	50	TNRC6A,HPSE2
2.936e-02	-3.53	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	2	19454	50	DST,SORBS1
2.940e-02	-3.53	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	49	SLC1A2
2.941e-02	-3.53	Gap junction	KEGG pathways	ko04540	88	2	7161	22	ADCY2,PRKG1
2.941e-02	-3.53	Gap junction	KEGG pathways	hsa04540	88	2	7161	22	ADCY2,PRKG1
2.972e-02	-3.52	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	17	16828	49	DCLK2,RPS6KA2,PITPNC1,QKI,PPP2R2B,TRPS1,MSI2,PRKG1,CTNND2,HIF3A,DAAM2,DCLK1,BMPR1B,SOX5,LIFR,ERBB4,CAMK2G
2.972e-02	-3.52	response to alkaloid	biological process	GO:0043279	100	2	18204	49	SLC1A2,RYR3
3.003e-02	-3.51	Dilated cardiomyopathy	KEGG pathways	ko05414	89	2	7161	22	TTN,ADCY2
3.003e-02	-3.51	Dilated cardiomyopathy	KEGG pathways	hsa05414	89	2	7161	22	TTN,ADCY2
3.005e-02	-3.50	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	49	SLC1A2,SLC25A18
3.027e-02	-3.50	regulation of carbohydrate biosynthetic process	biological process	GO:0043255	101	2	18204	49	SORBS1,PRKG1
3.030e-02	-3.50	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	49	DPP10,FMN2,ERBB4,CTNND2,DST
3.040e-02	-3.49	MELK (maternal embryonic leucine zipper kinase)	protein interactions	9833	106	2	19454	50	CAMK2G,DCLK1
3.042e-02	-3.49	CTF1 (cardiotrophin 1)	protein interactions	1489	12	1	19454	50	LIFR
3.042e-02	-3.49	ANKRD2 (ankyrin repeat domain 2)	protein interactions	26287	12	1	19454	50	TTN
3.042e-02	-3.49	INTS4P2 (integrator complex subunit 4 pseudogene 2)	protein interactions	644619	12	1	19454	50	GFAP
3.042e-02	-3.49	OAS2 (2'-5'-oligoadenylate synthetase 2)	protein interactions	4939	12	1	19454	50	PRKG1
3.042e-02	-3.49	SMIM20 (small integral membrane protein 20)	protein interactions	389203	12	1	19454	50	ERBB4
3.042e-02	-3.49	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	50	ERBB4
3.042e-02	-3.49	ABLIM2 (actin binding LIM protein family member 2)	protein interactions	84448	12	1	19454	50	TTN
3.042e-02	-3.49	CDHR2 (cadherin related family member 2)	protein interactions	54825	12	1	19454	50	RPS6KA2
3.042e-02	-3.49	MYBPHL (myosin binding protein H like)	protein interactions	343263	12	1	19454	50	GFAP
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.060e-02	-3.49	Type I hemidesmosome assembly	REACTOME pathways	R-HSA-446107	11	1	10285	29	DST
3.092e-02	-3.48	GRB2 events in EGFR signaling	REACTOME pathways	R-HSA-179812	245	3	10285	29	ERBB4,CAMK2G,NRG3
3.092e-02	-3.48	SHC1 events in EGFR signaling	REACTOME pathways	R-HSA-180336	245	3	10285	29	NRG3,ERBB4,CAMK2G
3.092e-02	-3.48	SOS-mediated signalling	REACTOME pathways	R-HSA-112412	245	3	10285	29	NRG3,ERBB4,CAMK2G
3.092e-02	-3.48	RAF/MAP kinase cascade	REACTOME pathways	R-HSA-5673001	245	3	10285	29	NRG3,ERBB4,CAMK2G
3.101e-02	-3.47	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	4	18204	49	DCLK1,CTNND2,PRKG1,BMPR1B
3.107e-02	-3.47	Drf_GBD	smart domains	SM01140	9	1	9717	34	DAAM2
3.107e-02	-3.47	Drf_FH3	smart domains	SM01139	9	1	9717	34	DAAM2
3.122e-02	-3.47	ESR1 (estrogen receptor 1)	protein interactions	2099	2322	11	19454	50	MSI2,ERBB4,RFX4,TRPS1,TNRC6A,SLC39A11,DST,TTN,DCLK1,CTNND2,MACF1
3.129e-02	-3.46	mRNA surveillance pathway	KEGG pathways	ko03015	91	2	7161	22	MSI2,PPP2R2B
3.129e-02	-3.46	mRNA surveillance pathway	KEGG pathways	hsa03015	91	2	7161	22	PPP2R2B,MSI2
3.130e-02	-3.46	Lipocalin_CS	interpro domains	IPR022272	12	1	18521	49	PTGDS
3.130e-02	-3.46	TGFB_receptor	interpro domains	IPR000333	12	1	18521	49	BMPR1B
3.130e-02	-3.46	Lipocalin	interpro domains	IPR002345	12	1	18521	49	PTGDS
3.138e-02	-3.46	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	4	18094	49	RYR3,SLC39A11,SLC1A2,TRPM3
3.142e-02	-3.46	ion binding	molecular function	GO:0043167	6007	23	18094	49	SLC1A2,ERBB4,RYR3,IQCA1,PCDH9,GLIS3,RPS6KA2,MGAT4C,DCLK1,PRKG1,DTNA,TRPS1,CAMK2G,ARAP2,PTGDS,BMPR1B,NAV2,PITPNC1,TTN,MACF1,ADCY2,DCLK2,DST
3.147e-02	-3.46	CLASP1 (cytoplasmic linker associated protein 1)	protein interactions	23332	108	2	19454	50	DCLK2,MACF1
3.147e-02	-3.46	ALDH3B1 (aldehyde dehydrogenase 3 family member B1)	protein interactions	221	108	2	19454	50	GFAP,FMN2
3.151e-02	-3.46	VCL (vinculin)	protein interactions	7414	268	3	19454	50	DST,MACF1,SORBS1
3.167e-02	-3.45	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	8	16828	49	DPP10,ARAP2,DST,ADCY2,ERBB4,NAV2,DAAM2,FMN2
3.172e-02	-3.45	anatomical structure morphogenesis	biological process	GO:0009653	2225	11	18204	49	HIF3A,NRG3,PRKG1,CTNND2,DCLK1,SOX5,BMPR1B,ERBB4,QKI,CDH20,TTN
3.184e-02	-3.45	microglia differentiation	biological process	GO:0014004	12	1	18204	49	QKI
3.184e-02	-3.45	urea transport	biological process	GO:0015840	12	1	18204	49	SLC14A1
3.184e-02	-3.45	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	49	BMPR1B
3.184e-02	-3.45	negative regulation of smooth muscle contraction	biological process	GO:0045986	12	1	18204	49	PRKG1
3.184e-02	-3.45	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	49	SLC1A2
3.184e-02	-3.45	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	49	BMPR1B
3.192e-02	-3.44	Progesterone-mediated oocyte maturation	KEGG pathways	hsa04914	92	2	7161	22	ADCY2,RPS6KA2
3.192e-02	-3.44	GnRH signaling pathway	KEGG pathways	hsa04912	92	2	7161	22	CAMK2G,ADCY2
3.192e-02	-3.44	Progesterone-mediated oocyte maturation	KEGG pathways	ko04914	92	2	7161	22	ADCY2,RPS6KA2
3.192e-02	-3.44	GnRH signaling pathway	KEGG pathways	ko04912	92	2	7161	22	CAMK2G,ADCY2
3.200e-02	-3.44	MIR34B (microRNA 34b)	protein interactions	407041	109	2	19454	50	QKI,MSI2
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	SOX5,TRPM3
3.203e-02	-3.44	dipeptidyl-peptidase activity	molecular function	GO:0008239	12	1	18094	49	DPP10
3.203e-02	-3.44	structural molecule activity conferring elasticity	molecular function	GO:0097493	12	1	18094	49	TTN
3.203e-02	-3.44	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	49	ADCY2
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	PITPNC1,AQP4,RPS6KA2,LSAMP,DCLK1,PCDH9,FMN2,CTNND2,SLC25A18,GLIS3,QKI,RFX4,SLC39A11,DCLK2,SOX5,CAMK2G,NRG3,MSI2,PRKG1,HIF3A,NAV2,SLC14A1,ARAP2,MGAT4C,NPAS3,BMPR1B,DPP10,TRPM3,SORBS1,TRPS1,NTM,HPSE2,PTGDS,DAAM2,CDH20,ABR,PPP2R2B,RYR3,WDR49,LIFR,SLC1A2,TNRC6A,ERBB4,ADCY2,DST,DTNA,GFAP,MACF1
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	NTM,HPSE2,DAAM2,PTGDS,TRPS1,SORBS1,TRPM3,NPAS3,BMPR1B,DPP10,ARAP2,MGAT4C,MACF1,GFAP,DTNA,ADCY2,TNRC6A,ERBB4,DST,LIFR,SLC1A2,WDR49,RYR3,ABR,CDH20,PPP2R2B,FMN2,CTNND2,DCLK1,LSAMP,PCDH9,AQP4,RPS6KA2,PITPNC1,HIF3A,NAV2,SLC14A1,NRG3,PRKG1,MSI2,CAMK2G,SOX5,DCLK2,RFX4,SLC39A11,GLIS3,QKI,SLC25A18
3.223e-02	-3.43	ARMS-mediated activation	REACTOME pathways	R-HSA-170984	249	3	10285	29	CAMK2G,ERBB4,NRG3
3.223e-02	-3.43	Signalling to p38 via RIT and RIN	REACTOME pathways	R-HSA-187706	249	3	10285	29	NRG3,CAMK2G,ERBB4
3.236e-02	-3.43	MIP	prosite domains	PS00221	10	1	12186	40	AQP4
3.236e-02	-3.43	MIR	prosite domains	PS50919	10	1	12186	40	RYR3
3.251e-02	-3.43	positive regulation of protein localization to membrane	biological process	GO:1905477	105	2	18204	49	DPP10,SORBS1
3.256e-02	-3.42	Frs2-mediated activation	REACTOME pathways	R-HSA-170968	250	3	10285	29	NRG3,ERBB4,CAMK2G
3.276e-02	-3.42	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	42	16828	49	ABR,CDH20,QKI,PPP2R2B,GLIS3,SLC25A18,RFX4,RYR3,WDR49,SLC39A11,ADCY2,ERBB4,TNRC6A,DST,LIFR,SOX5,SLC1A2,HIF3A,MACF1,SLC14A1,NAV2,NRG3,GFAP,PRKG1,ARAP2,MGAT4C,PITPNC1,AQP4,TRPM3,SORBS1,DCLK1,LSAMP,PCDH9,NPAS3,DPP10,BMPR1B,FMN2,NTM,CTNND2,HPSE2,DAAM2,TRPS1
3.284e-02	-3.42	cytoplasmic side of lysosomal membrane	cellular component	GO:0098574	13	1	19108	49	GFAP
3.289e-02	-3.41	MAPK1/MAPK3 signaling	REACTOME pathways	R-HSA-5684996	251	3	10285	29	NRG3,CAMK2G,ERBB4
3.291e-02	-3.41	CEACAM16 (CEA cell adhesion molecule 16, tectorial membrane component)	protein interactions	388551	13	1	19454	50	DST
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	NPR2 (natriuretic peptide receptor 2)	protein interactions	4882	13	1	19454	50	CAMK2G
3.291e-02	-3.41	MYBPC3 (myosin binding protein C3)	protein interactions	4607	13	1	19454	50	TTN
3.291e-02	-3.41	Rbm47 (RNA binding motif protein 47)	protein interactions	245945	13	1	19454	50	QKI
3.302e-02	-3.41	FLOT2 (flotillin 2)	protein interactions	2319	273	3	19454	50	SLC14A1,RPS6KA2,SOX5
3.306e-02	-3.41	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	28	16828	49	LSAMP,PCDH9,BMPR1B,DPP10,FMN2,CTNND2,HPSE2,ARAP2,LIFR,SOX5,SLC1A2,ADCY2,ERBB4,TNRC6A,NRG3,PRKG1,MACF1,NAV2,SLC25A18,ABR,CDH20,GLIS3,QKI,PPP2R2B,RFX4,WDR49,RYR3,SLC39A11
3.306e-02	-3.41	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	2	16828	49	CTNND2,LSAMP
3.307e-02	-3.41	oogenesis	biological process	GO:0048477	106	2	18204	49	FMN2,BMPR1B
3.316e-02	-3.41	EF_HAND_2	prosite domains	PS50222	215	3	12186	40	RYR3,DST,MACF1
3.322e-02	-3.40	Prolonged ERK activation events	REACTOME pathways	R-HSA-169893	252	3	10285	29	ERBB4,CAMK2G,NRG3
3.333e-02	-3.40	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	29	HIF3A
3.349e-02	-3.40	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	9	18204	49	TTN,ERBB4,RPS6KA2,PRKG1,DCLK1,BMPR1B,CAMK2G,DCLK2,ADCY2
3.356e-02	-3.39	Signaling by Leptin	REACTOME pathways	R-HSA-2586552	253	3	10285	29	NRG3,CAMK2G,ERBB4
3.361e-02	-3.39	Ion_trans	pfam domains	PF00520	109	2	17795	47	RYR3,TRPM3
3.363e-02	-3.39	MPP1 (MAGUK p55 scaffold protein 1)	protein interactions	4354	112	2	19454	50	TRPS1,RPS6KA2
3.363e-02	-3.39	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	2	19454	50	TRPS1,SOX5
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	MACF1,TRPS1
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	RPS6KA2,ERBB4
3.373e-02	-3.39	Cadherin_CS	interpro domains	IPR020894	109	2	18521	49	CDH20,PCDH9
3.373e-02	-3.39	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	49	TRPM3,RYR3
3.389e-02	-3.38	human chr3q26.1	chromosome location	human chr3q26.1	18	1	26134	50	WDR49
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.394e-02	-3.38	ACTR3 (actin related protein 3)	protein interactions	10096	276	3	19454	50	TNRC6A,DST,SORBS1
3.396e-02	-3.38	regulation of nervous system development	biological process	GO:0051960	456	4	18204	49	MACF1,GFAP,QKI,DAAM2
3.396e-02	-3.38	pattern specification process	biological process	GO:0007389	456	4	18204	49	ERBB4,NRG3,DAAM2,BMPR1B
3.402e-02	-3.38	beta-catenin binding	molecular function	GO:0008013	107	2	18094	49	CTNND2,CDH20
3.405e-02	-3.38	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	6	19454	50	TRPS1,CTNND2,PPP2R2B,CAMK2G,TTN,ADCY2
3.424e-02	-3.37	Interleukin receptor SHC signaling	REACTOME pathways	R-HSA-912526	255	3	10285	29	NRG3,ERBB4,CAMK2G
3.425e-02	-3.37	RBFOX2 (RNA binding fox-1 homolog 2)	protein interactions	23543	277	3	19454	50	TNRC6A,QKI,MSI2
3.438e-02	-3.37	Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME pathways	R-HSA-881907	443	4	10285	29	NRG3,RPS6KA2,ERBB4,CAMK2G
3.440e-02	-3.37	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	12	1	16828	49	QKI
3.444e-02	-3.37	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	29	RYR3,TRPM3
3.444e-02	-3.37	nervous system process involved in regulation of systemic arterial blood pressure	biological process	GO:0001976	13	1	18204	49	NAV2
3.444e-02	-3.37	olfactory bulb interneuron differentiation	biological process	GO:0021889	13	1	18204	49	ERBB4
3.444e-02	-3.37	ectodermal placode development	biological process	GO:0071696	13	1	18204	49	NRG3
3.444e-02	-3.37	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	biological process	GO:0060213	13	1	18204	49	TNRC6A
3.444e-02	-3.37	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	49	PRKG1
3.446e-02	-3.37	MIR	smart domains	SM00472	10	1	9717	34	RYR3
3.458e-02	-3.36	Signalling to RAS	REACTOME pathways	R-HSA-167044	256	3	10285	29	NRG3,CAMK2G,ERBB4
3.465e-02	-3.36	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	49	BMPR1B
3.474e-02	-3.36	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	50	PCDH9,MACF1
3.481e-02	-3.36	long-chain fatty acid metabolic process	biological process	GO:0001676	109	2	18204	49	PTGDS,QKI
3.481e-02	-3.36	regulation of protein localization to plasma membrane	biological process	GO:1903076	109	2	18204	49	DPP10,SORBS1
3.501e-02	-3.35	lower_third	COSMIC cancer mutations	lower_third	7961	30	16828	49	MGAT4C,AQP4,RPS6KA2,DCLK1,DPP10,PCDH9,NPAS3,SORBS1,TRPM3,TRPS1,CTNND2,FMN2,DAAM2,HPSE2,CDH20,QKI,SLC39A11,WDR49,RYR3,DCLK2,SOX5,LIFR,ADCY2,TNRC6A,ERBB4,DST,NRG3,PRKG1,NAV2,MACF1
3.506e-02	-3.35	EV release from cardiac cells and their functional effects	WikiPathways	WP3297	9	1	5310	21	ERBB4
3.518e-02	-3.35	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	2	7161	22	CAMK2G,ADCY2
3.518e-02	-3.35	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	2	7161	22	ADCY2,CAMK2G
3.527e-02	-3.34	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	3	10285	29	ERBB4,CAMK2G,NRG3
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	SOX5,BMPR1B
3.531e-02	-3.34	Cadherin	pfam domains	PF00028	112	2	17795	47	CDH20,PCDH9
3.540e-02	-3.34	SH3YL1 (SH3 and SYLF domain containing 1)	protein interactions	26751	14	1	19454	50	GFAP
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	FCGBP (Fc gamma binding protein)	protein interactions	8857	14	1	19454	50	PPP2R2B
3.540e-02	-3.34	CABS1 (calcium binding protein, spermatid associated 1)	protein interactions	85438	14	1	19454	50	GFAP
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	CFAP58 (cilia and flagella associated protein 58)	protein interactions	159686	14	1	19454	50	NAV2
3.540e-02	-3.34	GAGE1 (G antigen 1)	protein interactions	2543	14	1	19454	50	PRKG1
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	CAMK2G
3.540e-02	-3.34	SPRR2D (small proline rich protein 2D)	protein interactions	6703	14	1	19454	50	PPP2R2B
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	CAMK2G
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	JMJD7-PLA2G4B (JMJD7-PLA2G4B readthrough)	protein interactions	8681	14	1	19454	50	PPP2R2B
3.540e-02	-3.34	Ssbp1 (single-stranded DNA binding protein 1)	protein interactions	381760	14	1	19454	50	TNRC6A
3.540e-02	-3.34	Tecpr2 (tectonin beta-propeller repeat containing 2)	protein interactions	104859	14	1	19454	50	DST
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	50	CAMK2G
3.544e-02	-3.34	bHLH_dom	interpro domains	IPR011598	112	2	18521	49	NPAS3,HIF3A
3.544e-02	-3.34	HLH_DNA-bd_sf	interpro domains	IPR036638	112	2	18521	49	HIF3A,NPAS3
3.553e-02	-3.34	GBD_FH3	prosite domains	PS51232	11	1	12186	40	DAAM2
3.553e-02	-3.34	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	40	TRPS1
3.553e-02	-3.34	LIPOCALIN	prosite domains	PS00213	11	1	12186	40	PTGDS
3.564e-02	-3.33	SH3 Domains	gene3d domains	2.30.30.40	223	3	14470	47	MACF1,DST,SORBS1
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.593e-02	-3.33	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	6	16828	49	PCDH9,DCLK1,GLIS3,HIF3A,FMN2,ERBB4
3.596e-02	-3.33	SH3	prosite domains	PS50002	222	3	12186	40	MACF1,DST,SORBS1
3.603e-02	-3.32	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	18	16828	49	ERBB4,DST,DCLK1,PCDH9,SLC1A2,FMN2,CTNND2,MACF1,NAV2,NRG3,TRPS1,CDH20,QKI,PPP2R2B,ARAP2,MGAT4C,RFX4,WDR49
3.606e-02	-3.32	Passive transport by Aquaporins	REACTOME pathways	R-HSA-432047	13	1	10285	29	AQP4
3.627e-02	-3.32	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	2	10285	29	SLC1A2,SLC25A18
3.636e-02	-3.31	GATA	pfam domains	PF00320	14	1	17795	47	TRPS1
3.636e-02	-3.31	MIP	pfam domains	PF00230	14	1	17795	47	AQP4
3.636e-02	-3.31	Zip	pfam domains	PF02535	14	1	17795	47	SLC39A11
3.637e-02	-3.31	Cellular responses to stress	REACTOME pathways	R-HSA-2262752	451	4	10285	29	CAMK2G,RPS6KA2,HIF3A,TNRC6A
3.642e-02	-3.31	MIP	interpro domains	IPR000425	14	1	18521	49	AQP4
3.642e-02	-3.31	ZIP	interpro domains	IPR003689	14	1	18521	49	SLC39A11
3.642e-02	-3.31	Aquaporin-like	interpro domains	IPR023271	14	1	18521	49	AQP4
3.642e-02	-3.31	PPP1R9A (protein phosphatase 1 regulatory subunit 9A)	protein interactions	55607	117	2	19454	50	DCLK1,DCLK2
3.647e-02	-3.31	phosphorus metabolic process	biological process	GO:0006793	1707	9	18204	49	RPS6KA2,ERBB4,TTN,ADCY2,DCLK2,CAMK2G,BMPR1B,DCLK1,PRKG1
3.660e-02	-3.31	Cadherin-like_dom	interpro domains	IPR002126	114	2	18521	49	CDH20,PCDH9
3.666e-02	-3.31	Interleukin-2 signaling	REACTOME pathways	R-HSA-451927	262	3	10285	29	NRG3,CAMK2G,ERBB4
3.668e-02	-3.31	CAV1 (caveolin 1)	protein interactions	857	719	5	19454	50	DST,DTNA,FMN2,MACF1,RPS6KA2
3.670e-02	-3.30	cell morphogenesis	biological process	GO:0000902	687	5	18204	49	CDH20,BMPR1B,DCLK1,CTNND2,PRKG1
3.673e-02	-3.30	calcium ion binding	molecular function	GO:0005509	683	5	18094	49	PCDH9,DST,TTN,MACF1,RYR3
3.676e-02	-3.30	heterocyclic compound binding	molecular function	GO:1901363	2263	11	18094	49	DCLK2,CAMK2G,NAV2,BMPR1B,DCLK1,RPS6KA2,ADCY2,PRKG1,IQCA1,ERBB4,TTN
3.702e-02	-3.30	Signalling to ERKs	REACTOME pathways	R-HSA-187687	263	3	10285	29	NRG3,ERBB4,CAMK2G
3.704e-02	-3.30	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	49	AQP4
3.704e-02	-3.30	negative regulation of oligodendrocyte differentiation	biological process	GO:0048715	14	1	18204	49	DAAM2
3.704e-02	-3.30	neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0099645	14	1	18204	49	ERBB4
3.704e-02	-3.30	regulation of skeletal muscle adaptation	biological process	GO:0014733	14	1	18204	49	CAMK2G
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	RYR3
3.704e-02	-3.30	protein localization to postsynaptic specialization membrane	biological process	GO:0099633	14	1	18204	49	ERBB4
3.704e-02	-3.30	cellular response to forskolin	biological process	GO:1904322	14	1	18204	49	ADCY2
3.704e-02	-3.30	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	49	SLC1A2
3.704e-02	-3.30	response to forskolin	biological process	GO:1904321	14	1	18204	49	ADCY2
3.717e-02	-3.29	developmental cell growth	biological process	GO:0048588	113	2	18204	49	DCLK1,PRKG1
3.721e-02	-3.29	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	13	1	16828	49	QKI
3.727e-02	-3.29	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	49	MACF1
3.729e-02	-3.29	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	13	16828	49	AQP4,RYR3,ARAP2,GLIS3,CTNND2,FMN2,NAV2,MACF1,ADCY2,CAMK2G,TRPM3,SORBS1,NPAS3
3.729e-02	-3.29	embryonal	COSMIC cancer mutations	embryonal	2659	13	16828	49	CTNND2,FMN2,NAV2,MACF1,ADCY2,CAMK2G,TRPM3,SORBS1,NPAS3,AQP4,RYR3,ARAP2,GLIS3
3.755e-02	-3.28	MAPK1 (mitogen-activated protein kinase 1)	protein interactions	5594	493	4	19454	50	RPS6KA2,TRPS1,LIFR,TTN
3.756e-02	-3.28	RBM7 (RNA binding motif protein 7)	protein interactions	10179	119	2	19454	50	PPP2R2B,QKI
3.756e-02	-3.28	ITGB4 (integrin subunit beta 4)	protein interactions	3691	119	2	19454	50	TNRC6A,DST
3.773e-02	-3.28	FCERI mediated MAPK activation	REACTOME pathways	R-HSA-2871796	265	3	10285	29	NRG3,CAMK2G,ERBB4
3.775e-02	-3.28	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	49	16828	49	MGAT4C,ARAP2,TRPS1,PTGDS,DAAM2,HPSE2,NTM,DPP10,BMPR1B,NPAS3,SORBS1,TRPM3,RYR3,WDR49,PPP2R2B,CDH20,ABR,GFAP,DTNA,MACF1,SLC1A2,LIFR,DST,ADCY2,ERBB4,TNRC6A,RPS6KA2,AQP4,PITPNC1,CTNND2,FMN2,PCDH9,LSAMP,DCLK1,SLC39A11,RFX4,DCLK2,SLC25A18,QKI,GLIS3,MSI2,PRKG1,NRG3,NAV2,SLC14A1,HIF3A,SOX5,IQCA1,CAMK2G
3.777e-02	-3.28	regulation of circadian rhythm	biological process	GO:0042752	114	2	18204	49	PTGDS,PRKG1
3.778e-02	-3.28	Cadherin-like_sf	interpro domains	IPR015919	116	2	18521	49	CDH20,PCDH9
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	27344	15	1	19454	50	MGAT4C
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	NPR1 (natriuretic peptide receptor 1)	protein interactions	4881	15	1	19454	50	PRKG1
3.788e-02	-3.27	Melanogenesis	KEGG pathways	hsa04916	101	2	7161	22	ADCY2,CAMK2G
3.788e-02	-3.27	Melanogenesis	KEGG pathways	ko04916	101	2	7161	22	CAMK2G,ADCY2
3.788e-02	-3.27	neuron projection development	biological process	GO:0031175	693	5	18204	49	GFAP,BMPR1B,DCLK1,CTNND2,PRKG1
3.799e-02	-3.27	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	40	ERBB4,TTN
3.810e-02	-3.27	YTHDF1 (YTH N6-methyladenosine RNA binding protein F1)	protein interactions	54915	289	3	19454	50	TNRC6A,QKI,RPS6KA2
3.814e-02	-3.27	EYA2 (EYA transcriptional coactivator and phosphatase 2)	protein interactions	2139	120	2	19454	50	TRPS1,TNRC6A
3.814e-02	-3.27	PJA1 (praja ring finger ubiquitin ligase 1)	protein interactions	64219	120	2	19454	50	ABR,SLC25A18
3.814e-02	-3.27	FHL1 (four and a half LIM domains 1)	protein interactions	2273	120	2	19454	50	TTN,MACF1
3.814e-02	-3.27	HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2)	protein interactions	144983	120	2	19454	50	TTN,MGAT4C
3.819e-02	-3.27	membrane raft	cellular component	GO:0045121	290	3	19108	49	SLC1A2,SORBS1,ADCY2
3.830e-02	-3.26	-	gene3d domains	3.10.450.50	12	1	14470	47	CAMK2G
3.837e-02	-3.26	cell growth	biological process	GO:0016049	115	2	18204	49	PRKG1,DCLK1
3.837e-02	-3.26	fatty acid biosynthetic process	biological process	GO:0006633	115	2	18204	49	PTGDS,QKI
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	ko04922	102	2	7161	22	ADCY2,CAMK2G
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	hsa04922	102	2	7161	22	ADCY2,CAMK2G
3.870e-02	-3.25	CNMP_BINDING_2	prosite domains	PS00889	12	1	12186	40	PRKG1
3.878e-02	-3.25	actin filament organization	biological process	GO:0007015	278	3	18204	49	FMN2,TTN,SORBS1
3.885e-02	-3.25	membrane microdomain	cellular component	GO:0098857	292	3	19108	49	SORBS1,SLC1A2,ADCY2
3.897e-02	-3.24	NTF2-like_dom_sf	interpro domains	IPR032710	15	1	18521	49	CAMK2G
3.897e-02	-3.24	Znf_GATA	interpro domains	IPR000679	15	1	18521	49	TRPS1
3.930e-02	-3.24	A2ML1 (alpha-2-macroglobulin like 1)	protein interactions	144568	122	2	19454	50	PPP2R2B,SLC39A11
3.943e-02	-3.23	EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1)	protein interactions	56478	293	3	19454	50	TNRC6A,DST,QKI
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.954e-02	-3.23	RET signaling	REACTOME pathways	R-HSA-8853659	270	3	10285	29	ERBB4,CAMK2G,NRG3
3.964e-02	-3.23	pyramidal neuron differentiation	biological process	GO:0021859	15	1	18204	49	DCLK2
3.964e-02	-3.23	neuroblast division	biological process	GO:0055057	15	1	18204	49	SOX5
3.964e-02	-3.23	negative regulation of amino acid transport	biological process	GO:0051956	15	1	18204	49	PRKG1
3.964e-02	-3.23	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	49	MACF1
3.964e-02	-3.23	response to caffeine	biological process	GO:0031000	15	1	18204	49	RYR3
3.964e-02	-3.23	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	49	SORBS1
3.964e-02	-3.23	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	49	RYR3
3.964e-02	-3.23	regulation of circadian sleep/wake cycle, sleep	biological process	GO:0045187	15	1	18204	49	PTGDS
3.964e-02	-3.23	protein homotrimerization	biological process	GO:0070207	15	1	18204	49	SLC1A2
3.964e-02	-3.23	regulation of nuclear-transcribed mRNA poly(A) tail shortening	biological process	GO:0060211	15	1	18204	49	TNRC6A
3.964e-02	-3.23	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	1	18204	49	PRKG1
3.964e-02	-3.23	collateral sprouting	biological process	GO:0048668	15	1	18204	49	PRKG1
3.972e-02	-3.23	microtubule binding	molecular function	GO:0008017	279	3	18094	49	MACF1,DCLK2,DST
3.983e-02	-3.22	positive regulation of protein localization	biological process	GO:1903829	480	4	18204	49	TTN,SORBS1,DPP10,ERBB4
3.988e-02	-3.22	C4-dicarboxylate transmembrane transporter activity	molecular function	GO:0015556	15	1	18094	49	SLC25A18
3.988e-02	-3.22	3'-5' DNA helicase activity	molecular function	GO:0043138	15	1	18094	49	NAV2
3.988e-02	-3.22	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	49	PITPNC1
3.988e-02	-3.22	protein-containing complex destabilizing activity	molecular function	GO:0140776	15	1	18094	49	IQCA1
3.988e-02	-3.22	muscle alpha-actinin binding	molecular function	GO:0051371	15	1	18094	49	TTN
3.988e-02	-3.22	ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)	protein interactions	3708	123	2	19454	50	CAMK2G,PRKG1
3.991e-02	-3.22	Interleukin-3, 5 and GM-CSF signaling	REACTOME pathways	R-HSA-512988	271	3	10285	29	CAMK2G,ERBB4,NRG3
4.002e-02	-3.22	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	2	18094	49	SLC25A18,SLC1A2
4.002e-02	-3.22	calcium channel activity	molecular function	GO:0005262	117	2	18094	49	TRPM3,RYR3
4.015e-02	-3.22	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	18	16828	49	NPAS3,DCLK1,TRPM3,SORBS1,ADCY2,TNRC6A,CAMK2G,TRPS1,NAV2,MACF1,CTNND2,FMN2,GLIS3,PPP2R2B,ARAP2,CDH20,RYR3,AQP4
4.020e-02	-3.21	MAPRE1 (microtubule associated protein RP/EB family member 1)	protein interactions	22919	504	4	19454	50	NAV2,MACF1,DST,CAMK2G
4.020e-02	-3.21	synapse assembly	biological process	GO:0007416	118	2	18204	49	NRG3,ERBB4
4.022e-02	-3.21	ErbB receptor signaling network	Pathway Interaction DB	erbb_network_pathway	13	1	2226	7	NRG3
4.035e-02	-3.21	ADAM18 (ADAM metallopeptidase domain 18)	protein interactions	8749	16	1	19454	50	RPS6KA2
4.035e-02	-3.21	CNTFR (ciliary neurotrophic factor receptor)	protein interactions	1271	16	1	19454	50	LIFR
4.035e-02	-3.21	KLHL25 (kelch like family member 25)	protein interactions	64410	16	1	19454	50	RPS6KA2
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKG1
4.035e-02	-3.21	TMEM134 (transmembrane protein 134)	protein interactions	80194	16	1	19454	50	ERBB4
4.035e-02	-3.21	Prkcz (protein kinase C, zeta)	protein interactions	18762	16	1	19454	50	DST
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	CAMK1G (calcium/calmodulin dependent protein kinase IG)	protein interactions	57172	16	1	19454	50	CAMK2G
4.035e-02	-3.21	IFFO2 (intermediate filament family orphan 2)	protein interactions	126917	16	1	19454	50	GFAP
4.035e-02	-3.21	CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2)	protein interactions	729438	16	1	19454	50	DST
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	MACF1
4.035e-02	-3.21	ORM2 (orosomucoid 2)	protein interactions	5005	16	1	19454	50	PPP2R2B
4.035e-02	-3.21	DUS1L (dihydrouridine synthase 1 like)	protein interactions	64118	16	1	19454	50	CAMK2G
4.047e-02	-3.21	CEBPA (CCAAT enhancer binding protein alpha)	protein interactions	1050	124	2	19454	50	MACF1,GFAP
4.054e-02	-3.21	Wnt signaling pathway	biological process	GO:0016055	283	3	18204	49	CTNND2,DAAM2,MACF1
4.079e-02	-3.20	SP7 (Sp7 transcription factor)	protein interactions	121340	297	3	19454	50	QKI,TRPS1,SOX5
4.106e-02	-3.19	TCHP (trichoplein keratin filament binding)	protein interactions	84260	125	2	19454	50	TNRC6A,GFAP
4.106e-02	-3.19	SLAMF1 (signaling lymphocytic activation molecule family member 1)	protein interactions	6504	125	2	19454	50	LIFR,SLC39A11
4.106e-02	-3.19	CARD10 (caspase recruitment domain family member 10)	protein interactions	29775	125	2	19454	50	GFAP,PTGDS
4.118e-02	-3.19	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	10	16828	49	HPSE2,FMN2,RYR3,WDR49,ARAP2,ERBB4,ADCY2,CDH20,PITPNC1,PCDH9
4.121e-02	-3.19	ZnF_GATA	smart domains	SM00401	12	1	9717	34	TRPS1
4.127e-02	-3.19	human chr2q31.2	chromosome location	human chr2q31.2	22	1	26134	50	TTN
4.127e-02	-3.19	human chr3q13.31	chromosome location	human chr3q13.31	22	1	26134	50	LSAMP
4.131e-02	-3.19	extremity	COSMIC cancer mutations	extremity	1876	10	16828	49	PCDH9,PITPNC1,CDH20,ERBB4,ADCY2,ARAP2,WDR49,RYR3,FMN2,HPSE2
4.138e-02	-3.18	neuron projection morphogenesis	biological process	GO:0048812	486	4	18204	49	BMPR1B,PRKG1,DCLK1,CTNND2
4.146e-02	-3.18	upper_leg	COSMIC cancer mutations	upper_leg	880	6	16828	49	HIF3A,FMN2,PCDH9,DCLK1,GLIS3,ERBB4
4.150e-02	-3.18	N-Glycan antennae elongation	REACTOME pathways	R-HSA-975577	15	1	10285	29	MGAT4C
4.150e-02	-3.18	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	29	ADCY2
4.150e-02	-3.18	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME pathways	R-HSA-2162123	15	1	10285	29	PTGDS
4.150e-02	-3.18	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	29	ADCY2
4.152e-02	-3.18	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	49	PRKG1
4.178e-02	-3.18	NCAM signaling for neurite out-growth	REACTOME pathways	R-HSA-375165	276	3	10285	29	NRG3,CAMK2G,ERBB4
4.207e-02	-3.17	catalytic activity, acting on a protein	molecular function	GO:0140096	2312	11	18094	49	CAMK2G,IQCA1,DCLK2,DPP10,BMPR1B,MGAT4C,ERBB4,RPS6KA2,DCLK1,PRKG1,TTN
4.208e-02	-3.17	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	19	16828	49	RPS6KA2,DCLK2,PPP2R2B,QKI,PITPNC1,DAAM2,HIF3A,FMN2,CTNND2,PRKG1,MSI2,TRPS1,DST,CAMK2G,ERBB4,LIFR,BMPR1B,SOX5,DCLK1
4.211e-02	-3.17	cell-cell junction	cellular component	GO:0005911	513	4	19108	49	SORBS1,CTNND2,CDH20,PCDH9
4.223e-02	-3.16	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	49	SLC1A2
4.223e-02	-3.16	asymmetric cell division	biological process	GO:0008356	16	1	18204	49	SOX5
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	QKI,TRPS1
4.226e-02	-3.16	DES (desmin)	protein interactions	1674	127	2	19454	50	DTNA,GFAP
4.248e-02	-3.16	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	49	ADCY2
4.248e-02	-3.16	cGMP binding	molecular function	GO:0030553	16	1	18094	49	PRKG1
4.248e-02	-3.16	water channel activity	molecular function	GO:0015250	16	1	18094	49	AQP4
4.270e-02	-3.15	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	4	18204	49	PRKG1,CTNND2,DCLK1,BMPR1B
4.271e-02	-3.15	muscle cell differentiation	biological process	GO:0042692	289	3	18204	49	QKI,PRKG1,TTN
4.282e-02	-3.15	hypothalamus	COSMIC cancer mutations	hypothalamus	15	1	16828	49	QKI
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	KRTAP19-3 (keratin associated protein 19-3)	protein interactions	337970	17	1	19454	50	CAMK2G
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	SHD (Src homology 2 domain containing transforming protein D)	protein interactions	56961	17	1	19454	50	ERBB4
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	Pef1 (penta-EF hand domain containing 1)	protein interactions	67898	17	1	19454	50	QKI
4.282e-02	-3.15	CLEC4M (C-type lectin domain family 4 member M)	protein interactions	10332	17	1	19454	50	GFAP
4.282e-02	-3.15	FAM163B (family with sequence similarity 163 member B)	protein interactions	642968	17	1	19454	50	CAMK2G
4.283e-02	-3.15	central_nervous_system-brainstem-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_III	113	2	16828	49	TNRC6A,ADCY2
4.286e-02	-3.15	CDCA8 (cell division cycle associated 8)	protein interactions	55143	128	2	19454	50	PPP2R2B,DCLK1
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.297e-02	-3.15	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	6	19454	50	DTNA,DST,PPP2R2B,MACF1,FMN2,ARAP2
4.311e-02	-3.14	human chr2q34	chromosome location	human chr2q34	23	1	26134	50	ERBB4
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.312e-02	-3.14	regulation of multicellular organismal development	biological process	GO:2000026	1484	8	18204	49	QKI,GFAP,ERBB4,TRPS1,MACF1,DAAM2,BMPR1B,SOX5
4.321e-02	-3.14	plasma membrane region	cellular component	GO:0098590	1278	7	19108	49	SORBS1,AQP4,ERBB4,SLC14A1,MACF1,DST,SLC1A2
4.321e-02	-3.14	CARM1 (coactivator associated arginine methyltransferase 1)	protein interactions	10498	304	3	19454	50	QKI,CAMK2G,DTNA
4.389e-02	-3.13	actin cytoskeleton	cellular component	GO:0015629	520	4	19108	49	FMN2,SORBS1,DST,MACF1
4.397e-02	-3.12	cardiocyte differentiation	biological process	GO:0035051	124	2	18204	49	PRKG1,TTN
4.398e-02	-3.12	ZZ	pfam domains	PF00569	17	1	17795	47	DTNA
4.404e-02	-3.12	cell projection morphogenesis	biological process	GO:0048858	496	4	18204	49	PRKG1,CTNND2,DCLK1,BMPR1B
4.406e-02	-3.12	PAC	interpro domains	IPR001610	17	1	18521	49	HIF3A
4.406e-02	-3.12	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	49	ADCY2
4.420e-02	-3.12	Rap1 signalling	REACTOME pathways	R-HSA-392517	16	1	10285	29	PRKG1
4.420e-02	-3.12	PKA activation	REACTOME pathways	R-HSA-163615	16	1	10285	29	ADCY2
4.455e-02	-3.11	Glycerol uptake facilitator protein	gene3d domains	1.20.1080.10	14	1	14470	47	AQP4
4.456e-02	-3.11	small molecule binding	molecular function	GO:0036094	6197	23	18094	49	NAV2,BMPR1B,CAMK2G,PTGDS,ARAP2,PRKG1,DTNA,TRPS1,GLIS3,RPS6KA2,MGAT4C,DCLK1,PCDH9,IQCA1,ERBB4,SLC1A2,RYR3,DST,DCLK2,ADCY2,MACF1,TTN,PITPNC1
4.459e-02	-3.11	regulation of anatomical structure size	biological process	GO:0090066	498	4	18204	49	PRKG1,DAAM2,AQP4,MACF1
4.461e-02	-3.11	actomyosin structure organization	biological process	GO:0031032	125	2	18204	49	TTN,SORBS1
4.461e-02	-3.11	mammary gland development	biological process	GO:0030879	125	2	18204	49	ERBB4,NRG3
4.464e-02	-3.11	MINTRINSICP	prints domains	PR00783	14	1	5227	17	AQP4
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	SLC1A2
4.481e-02	-3.11	preganglionic parasympathetic fiber development	biological process	GO:0021783	17	1	18204	49	NAV2
4.481e-02	-3.11	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	49	SORBS1
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	RYR3
4.481e-02	-3.11	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	49	ERBB4
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	SLC25A18,QKI,GLIS3,SLC39A11,RFX4,DCLK2,SOX5,IQCA1,CAMK2G,MSI2,PRKG1,NRG3,NAV2,SLC14A1,HIF3A,PITPNC1,RPS6KA2,AQP4,PCDH9,DCLK1,LSAMP,CTNND2,FMN2,PPP2R2B,ABR,CDH20,WDR49,RYR3,SLC1A2,LIFR,DST,ADCY2,ERBB4,TNRC6A,GFAP,DTNA,MACF1,MGAT4C,ARAP2,BMPR1B,DPP10,NPAS3,TRPM3,SORBS1,TRPS1,PTGDS,DAAM2,HPSE2,NTM
4.519e-02	-3.10	protein phosphatase type 2A complex	cellular component	GO:0000159	18	1	19108	49	PPP2R2B
4.529e-02	-3.09	ADAT2 (adenosine deaminase tRNA specific 2)	protein interactions	134637	18	1	19454	50	NAV2
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	SERTAD4 (SERTA domain containing 4)	protein interactions	56256	18	1	19454	50	PPP2R2B
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	PTGFR (prostaglandin F receptor)	protein interactions	5737	18	1	19454	50	PTGDS
4.529e-02	-3.09	ORF45 (ORF45)	protein interactions	4961474	18	1	19454	50	RPS6KA2
4.529e-02	-3.09	IRGC (immunity related GTPase cinema)	protein interactions	56269	18	1	19454	50	RPS6KA2
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKG1
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.530e-02	-3.09	SUDS3 (SDS3 homolog, SIN3A corepressor complex component)	protein interactions	64426	132	2	19454	50	RPS6KA2,PPP2R2B
4.530e-02	-3.09	HAL (histidine ammonia-lyase)	protein interactions	3034	132	2	19454	50	SLC39A11,PPP2R2B
4.531e-02	-3.09	positive regulation of nervous system development	biological process	GO:0051962	296	3	18204	49	QKI,GFAP,MACF1
4.561e-02	-3.09	eye-uveal_tract-malignant_melanoma-epithelioid	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-epithelioid	16	1	16828	49	TNRC6A
4.569e-02	-3.09	carboxylic acid transport	biological process	GO:0046942	297	3	18204	49	SLC25A18,SLC1A2,GFAP
4.569e-02	-3.09	Cholinergic synapse	KEGG pathways	hsa04725	112	2	7161	22	ADCY2,CAMK2G
4.591e-02	-3.08	NES (nestin)	protein interactions	10763	133	2	19454	50	TNRC6A,GFAP
4.604e-02	-3.08	SLC-mediated transmembrane transport	REACTOME pathways	R-HSA-425407	287	3	10285	29	SLC14A1,SLC1A2,SLC25A18
4.607e-02	-3.08	organic acid transport	biological process	GO:0015849	298	3	18204	49	SLC1A2,GFAP,SLC25A18
4.624e-02	-3.07	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	47	ERBB4,BMPR1B
4.629e-02	-3.07	LPA4-mediated signaling events	Pathway Interaction DB	lpa4_pathway	15	1	2226	7	ADCY2
4.629e-02	-3.07	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	Pathway Interaction DB	hif1apathway	15	1	2226	7	HIF3A
4.649e-02	-3.07	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	21	RYR3
4.649e-02	-3.07	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	21	BMPR1B
4.651e-02	-3.07	Guanylate_cyc	pfam domains	PF00211	18	1	17795	47	ADCY2
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	DCLK1,NTM
4.654e-02	-3.07	channel activity	molecular function	GO:0015267	502	4	18094	49	SLC14A1,TRPM3,AQP4,RYR3
4.654e-02	-3.07	nitrogen compound transport	biological process	GO:0071705	1507	8	18204	49	SLC1A2,CAMK2G,MACF1,SLC25A18,QKI,GFAP,FMN2,SLC14A1
4.659e-02	-3.07	A/G_cyclase	interpro domains	IPR001054	18	1	18521	49	ADCY2
4.659e-02	-3.07	Furin_repeat	interpro domains	IPR006212	18	1	18521	49	ERBB4
4.659e-02	-3.07	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	49	ADCY2
4.682e-02	-3.06	passive transmembrane transporter activity	molecular function	GO:0022803	503	4	18094	49	SLC14A1,TRPM3,AQP4,RYR3
4.690e-02	-3.06	PKA activation in glucagon signalling	REACTOME pathways	R-HSA-164378	17	1	10285	29	ADCY2
4.690e-02	-3.06	Unblocking of NMDA receptor, glutamate binding and activation	REACTOME pathways	R-HSA-438066	17	1	10285	29	CAMK2G
4.690e-02	-3.06	CREB phosphorylation through the activation of CaMKII	REACTOME pathways	R-HSA-442729	17	1	10285	29	CAMK2G
4.690e-02	-3.06	PKA-mediated phosphorylation of CREB	REACTOME pathways	R-HSA-111931	17	1	10285	29	ADCY2
4.716e-02	-3.05	MTNR1B (melatonin receptor 1B)	protein interactions	4544	135	2	19454	50	DST,MACF1
4.716e-02	-3.05	FAM83H (family with sequence similarity 83 member H)	protein interactions	286077	135	2	19454	50	GFAP,PPP2R2B
4.718e-02	-3.05	Glutamatergic synapse	KEGG pathways	ko04724	114	2	7161	22	ADCY2,SLC1A2
4.718e-02	-3.05	Glutamatergic synapse	KEGG pathways	hsa04724	114	2	7161	22	SLC1A2,ADCY2
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	CAMK2G,SOX5,IQCA1,SLC14A1,NAV2,HIF3A,PRKG1,MSI2,NRG3,QKI,GLIS3,SLC25A18,DCLK2,SLC39A11,RFX4,PCDH9,LSAMP,DCLK1,FMN2,CTNND2,PITPNC1,RPS6KA2,AQP4,DST,ERBB4,ADCY2,TNRC6A,LIFR,SLC1A2,MACF1,DTNA,GFAP,PPP2R2B,CDH20,ABR,WDR49,RYR3,TRPM3,SORBS1,NPAS3,DPP10,BMPR1B,HPSE2,DAAM2,PTGDS,NTM,TRPS1,ARAP2,MGAT4C
4.727e-02	-3.05	regulation of cellular localization	biological process	GO:0060341	983	6	18204	49	DCLK2,ERBB4,DPP10,TTN,SORBS1,DCLK1
4.737e-02	-3.05	circulatory system process	biological process	GO:0003013	508	4	18204	49	SLC1A2,NAV2,TTN,PRKG1
4.738e-02	-3.05	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	49	PRKG1
4.738e-02	-3.05	negative regulation of platelet activation	biological process	GO:0010544	18	1	18204	49	PRKG1
4.738e-02	-3.05	copper ion transport	biological process	GO:0006825	18	1	18204	49	SLC39A11
4.738e-02	-3.05	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	49	CTNND2
4.738e-02	-3.05	maintenance of cell polarity	biological process	GO:0030011	18	1	18204	49	DST
4.738e-02	-3.05	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	49	TTN
4.738e-02	-3.05	mitotic chromosome condensation	biological process	GO:0007076	18	1	18204	49	TTN
4.744e-02	-3.05	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	19	16828	49	PITPNC1,QKI,PPP2R2B,DCLK2,RPS6KA2,DCLK1,PCDH9,LIFR,BMPR1B,SOX5,CAMK2G,ERBB4,PRKG1,MSI2,TRPS1,HIF3A,CTNND2,MACF1,DAAM2
4.744e-02	-3.05	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	19	16828	49	DCLK2,RPS6KA2,PITPNC1,QKI,PPP2R2B,TRPS1,MSI2,PRKG1,CTNND2,HIF3A,DAAM2,MACF1,DCLK1,SOX5,BMPR1B,PCDH9,LIFR,ERBB4,CAMK2G
4.754e-02	-3.05	ZYX (zyxin)	protein interactions	7791	316	3	19454	50	TNRC6A,MACF1,SORBS1
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	CTNND2,ERBB4,DCLK1
4.766e-02	-3.04	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	49	HPSE2
4.766e-02	-3.04	GABA receptor binding	molecular function	GO:0050811	18	1	18094	49	ERBB4
4.766e-02	-3.04	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	49	NRG3
4.766e-02	-3.04	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	49	RYR3
4.766e-02	-3.04	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	49	PITPNC1
4.774e-02	-3.04	HBEGF (heparin binding EGF like growth factor)	protein interactions	1839	19	1	19454	50	ERBB4
4.774e-02	-3.04	Mtx1 (metaxin 1)	protein interactions	17827	19	1	19454	50	CAMK2G
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)	protein interactions	6236	19	1	19454	50	CAMK2G
4.774e-02	-3.04	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	50	CAMK2G
4.774e-02	-3.04	ZNF532 (zinc finger protein 532)	protein interactions	55205	19	1	19454	50	ERBB4
4.774e-02	-3.04	PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2)	protein interactions	57546	19	1	19454	50	GFAP
4.774e-02	-3.04	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	protein interactions	3754	19	1	19454	50	GFAP
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	PLA2G4E (phospholipase A2 group IVE)	protein interactions	123745	19	1	19454	50	PPP2R2B
4.809e-02	-3.03	N-glycan biosynthesis, complex type	KEGG pathways	M00075	16	1	7161	22	MGAT4C
4.809e-02	-3.03	N-glycan biosynthesis, complex type	KEGG pathways	hsa_M00075	16	1	7161	22	MGAT4C
4.809e-02	-3.03	cAMP signaling	KEGG pathways	hsa_M00695	16	1	7161	22	ADCY2
4.809e-02	-3.03	cAMP signaling	KEGG pathways	M00695	16	1	7161	22	ADCY2
4.834e-02	-3.03	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	2	18521	49	BMPR1B,ERBB4
4.839e-02	-3.03	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	17	1	16828	49	QKI
4.839e-02	-3.03	optic_nerve	COSMIC cancer mutations	optic_nerve	17	1	16828	49	QKI
4.843e-02	-3.03	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	49	DTNA,CDH20
4.852e-02	-3.03	response to calcium ion	biological process	GO:0051592	131	2	18204	49	RYR3,TTN
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.881e-02	-3.02	Ion Channels and Their Functional Role in Vascular Endothelium	SMPDB pathways	SMP0063778	17	1	1369	4	PRKG1
4.886e-02	-3.02	IRS-mediated signalling	REACTOME pathways	R-HSA-112399	294	3	10285	29	ERBB4,CAMK2G,NRG3
4.905e-02	-3.01	EXOC1 (exocyst complex component 1)	protein interactions	55763	138	2	19454	50	MACF1,DST
4.905e-02	-3.01	NFIB (nuclear factor I B)	protein interactions	4781	138	2	19454	50	SOX5,TRPS1
4.911e-02	-3.01	Znf_ZZ	interpro domains	IPR000433	19	1	18521	49	DTNA
4.911e-02	-3.01	Znf_ZZ_sf	interpro domains	IPR043145	19	1	18521	49	DTNA
4.933e-02	-3.01	parathyroid	COSMIC cancer mutations	parathyroid	476	4	16828	49	TRPS1,RYR3,PRKG1,MACF1
4.960e-02	-3.00	cGMP effects	REACTOME pathways	R-HSA-418457	18	1	10285	29	PRKG1
4.961e-02	-3.00	CADHERIN_1	prosite domains	PS00232	109	2	12186	40	CDH20,PCDH9
4.962e-02	-3.00	thalamus	COSMIC cancer mutations	thalamus	284	3	16828	49	TNRC6A,QKI,DTNA
4.968e-02	-3.00	KRTAP9-3 (keratin associated protein 9-3)	protein interactions	83900	139	2	19454	50	SLC25A18,NTM
4.968e-02	-3.00	MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)	protein interactions	9223	139	2	19454	50	RPS6KA2,DCLK1
4.995e-02	-3.00	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	49	PRKG1
4.995e-02	-3.00	parasympathetic nervous system development	biological process	GO:0048486	19	1	18204	49	NAV2
4.995e-02	-3.00	vascular associated smooth muscle cell differentiation	biological process	GO:0035886	19	1	18204	49	QKI
4.995e-02	-3.00	regulation of circadian sleep/wake cycle	biological process	GO:0042749	19	1	18204	49	PTGDS
4.995e-02	-3.00	regulation of glutamate secretion	biological process	GO:0014048	19	1	18204	49	PRKG1
4.995e-02	-3.00	regulation of neurotransmitter uptake	biological process	GO:0051580	19	1	18204	49	GFAP