Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
8.096e-09	-18.63	synapse pruning	biological process	GO:0098883	10	4	18204	47	TREM2,C1QA,C1QB,C1QC
1.585e-08	-17.96	complement component C1 complex	cellular component	GO:0005602	3	3	19108	49	C1QC,C1QB,C1QA
1.585e-08	-17.96	complement component C1q complex	cellular component	GO:0062167	3	3	19108	49	C1QA,C1QB,C1QC
3.830e-08	-17.08	cell junction disassembly	biological process	GO:0150146	14	4	18204	47	TREM2,C1QA,C1QC,C1QB
1.607e-07	-15.64	chylomicron remnant clearance	biological process	GO:0034382	5	3	18204	47	APOC1,APOE,APOC2
2.825e-07	-15.08	defense response	biological process	GO:0006952	1431	16	18204	47	TREM2,RNASET2,WNT5A,C1QC,AXL,CSF1R,FOLR2,CXCL12,HAVCR2,CD68,ALPK1,C3AR1,C1QA,CH25H,ADORA3,C1QB
3.209e-07	-14.95	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	3	18204	47	APOC1,APOE,APOC2
4.045e-07	-14.72	response to external stimulus	biological process	GO:0009605	1882	18	18204	47	WNT5A,PDGFA,RNASET2,TREM2,C1QC,CSF1R,AXL,FOLR2,CXCL12,USP53,C3AR1,ALPK1,CD68,HAVCR2,CH25H,MEF2C,C1QA,C1QB
4.142e-07	-14.70	regulation of lipid localization	biological process	GO:1905952	183	7	18204	47	ABCB4,SPP1,APOC2,APOC1,TREM2,APOE,PPARD
8.458e-07	-13.98	cellular response to lipid	biological process	GO:0071396	534	10	18204	47	KCNMB1,SPP1,MEF2C,AXL,ABCB4,PPARD,HAVCR2,CD68,WNT5A,TREM2
1.000e-06	-13.82	Classical antibody-mediated complement activation	REACTOME pathways	R-HSA-173623	6	3	10285	39	C1QC,C1QA,C1QB
1.280e-06	-13.57	inflammatory response	biological process	GO:0006954	559	10	18204	47	C3AR1,HAVCR2,CD68,WNT5A,TREM2,FOLR2,ADORA3,C1QA,AXL,CSF1R
1.585e-06	-13.36	regulation of sterol transport	biological process	GO:0032371	77	5	18204	47	APOC1,TREM2,ABCB4,APOE,APOC2
1.585e-06	-13.36	regulation of cholesterol transport	biological process	GO:0032374	77	5	18204	47	APOC1,ABCB4,TREM2,APOE,APOC2
2.485e-06	-12.91	regulation of lipid transport	biological process	GO:0032368	152	6	18204	47	APOE,SPP1,APOC2,TREM2,APOC1,ABCB4
3.201e-06	-12.65	APOA1 (apolipoprotein A1)	protein interactions	335	159	6	19454	50	C1QC,SPP1,APOC1,C1QA,APOC2,TREM2
3.237e-06	-12.64	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	15	19454	50	ADORA3,APOC1,ITM2B,CXCL12,C1QC,C1QB,FOLR2,ABCB4,WNT5A,DHRS9,GPR34,TREM2,OSBPL1A,APOE,C1QA
3.313e-06	-12.62	cellular response to chemical stimulus	biological process	GO:0070887	2411	19	18204	47	WNT5A,CSF2RA,TREM2,PPARD,APOE,CSF1R,ABCB4,AXL,SPP1,FOLR2,CXCL12,LTC4S,RGS10,P2RY13,CD68,HAVCR2,CH25H,MEF2C,KCNMB1
3.832e-06	-12.47	positive regulation of mononuclear cell migration	biological process	GO:0071677	92	5	18204	47	WNT5A,TREM2,CSF1R,C3AR1,CXCL12
4.105e-06	-12.40	steroid metabolic process	biological process	GO:0008202	258	7	18204	47	CH25H,SPP1,OSBPL1A,APOC1,DHRS9,APOE,PPARD
4.239e-06	-12.37	biological process involved in interspecies interaction between organisms	biological process	GO:0044419	1540	15	18204	47	ALPK1,CD68,HAVCR2,C1QB,CH25H,MEF2C,C1QA,C1QC,APOE,WNT5A,RNASET2,TREM2,CXCL12,CSF1R,AXL
4.451e-06	-12.32	chylomicron	cellular component	GO:0042627	13	3	19108	49	APOC1,APOC2,APOE
4.530e-06	-12.30	phospholipid efflux	biological process	GO:0033700	13	3	18204	47	APOC1,APOE,APOC2
4.655e-06	-12.28	cell periphery	cellular component	GO:0071944	6020	31	19108	49	GPR34,KCNMB1,C3AR1,ACY3,AXL,TSPAN15,CXCL12,OSBPL1A,IFITM10,ITM2B,COL18A1,ADORA3,RGS10,TREM2,WNT5A,SIGLEC8,C1QA,CD68,ADAP2,APOE,FOLR2,RGL3,CSF1R,EPB41L2,C1QB,DCBLD1,HAVCR2,CSF2RA,C1QC,ABCB4,P2RY13
4.703e-06	-12.27	immune response	biological process	GO:0006955	1349	14	18204	47	HAVCR2,CD68,ALPK1,C1QA,MEF2C,CH25H,C1QB,TREM2,WNT5A,RNASET2,C1QC,AXL,CSF1R,CXCL12
5.304e-06	-12.15	response to other organism	biological process	GO:0051707	1363	14	18204	47	TREM2,RNASET2,WNT5A,C1QC,AXL,CSF1R,CXCL12,HAVCR2,ALPK1,CD68,MEF2C,C1QA,CH25H,C1QB
5.350e-06	-12.14	positive regulation of immune system process	biological process	GO:0002684	986	12	18204	47	WNT5A,TREM2,C1QC,CSF1R,AXL,CXCL12,C3AR1,ALPK1,HAVCR2,MEF2C,C1QA,C1QB
5.441e-06	-12.12	response to external biotic stimulus	biological process	GO:0043207	1366	14	18204	47	C1QC,TREM2,WNT5A,RNASET2,CXCL12,CSF1R,AXL,CD68,ALPK1,HAVCR2,C1QB,C1QA,MEF2C,CH25H
7.724e-06	-11.77	response to biotic stimulus	biological process	GO:0009607	1408	14	18204	47	HAVCR2,CD68,ALPK1,C1QB,C1QA,MEF2C,CH25H,C1QC,TREM2,RNASET2,WNT5A,CXCL12,AXL,CSF1R
9.500e-06	-11.56	response to stress	biological process	GO:0006950	3388	22	18204	47	COL18A1,C3AR1,ALPK1,CD68,HAVCR2,ADORA3,CH25H,C1QA,MEF2C,C1QB,KCNMB1,PDGFA,WNT5A,RNASET2,TREM2,PPARD,APOE,C1QC,CSF1R,AXL,CXCL12,FOLR2
1.006e-05	-11.51	negative regulation of lipid metabolic process	biological process	GO:0045833	112	5	18204	47	APOE,APOC2,APOC1,PDGFA,CH25H
1.083e-05	-11.43	Creation of C4 and C2 activators	REACTOME pathways	R-HSA-166786	12	3	10285	39	C1QA,C1QB,C1QC
1.285e-05	-11.26	LETMD1 (LETM1 domain containing 1)	protein interactions	25875	56	4	19454	50	C3AR1,APOC1,TSPAN15,APOC2
1.351e-05	-11.21	cholesterol metabolic process	biological process	GO:0008203	119	5	18204	47	APOE,PPARD,OSBPL1A,APOC1,CH25H
1.380e-05	-11.19	endoplasmic reticulum lumen	cellular component	GO:0005788	312	7	19108	49	RNASET2,TSPAN15,PDGFA,APOE,WNT5A,COL18A1,SPP1
1.551e-05	-11.07	innate immune response	biological process	GO:0045087	741	10	18204	47	WNT5A,RNASET2,HAVCR2,C1QC,ALPK1,AXL,C1QA,CSF1R,CH25H,C1QB
1.583e-05	-11.05	cellular response to organic substance	biological process	GO:0071310	1716	15	18204	47	PPARD,WNT5A,CSF2RA,TREM2,SPP1,CXCL12,FOLR2,ABCB4,CSF1R,AXL,CD68,HAVCR2,P2RY13,KCNMB1,MEF2C
1.752e-05	-10.95	triglyceride-rich plasma lipoprotein particle	cellular component	GO:0034385	20	3	19108	49	APOE,APOC2,APOC1
1.752e-05	-10.95	very-low-density lipoprotein particle	cellular component	GO:0034361	20	3	19108	49	APOC1,APOE,APOC2
1.920e-05	-10.86	regulation of lipid metabolic process	biological process	GO:0019216	327	7	18204	47	APOC2,CH25H,PPARD,APOE,PDGFA,APOC1,TREM2
1.954e-05	-10.84	primary heart field specification	biological process	GO:0003138	3	2	18204	47	MEF2C,WNT5A
1.954e-05	-10.84	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	2	18204	47	APOC1,APOE
2.073e-05	-10.78	secondary alcohol metabolic process	biological process	GO:1902652	130	5	18204	47	APOC1,CH25H,APOE,PPARD,OSBPL1A
2.120e-05	-10.76	cellular response to molecule of bacterial origin	biological process	GO:0071219	221	6	18204	47	CD68,HAVCR2,TREM2,WNT5A,AXL,MEF2C
2.156e-05	-10.74	immune system process	biological process	GO:0002376	1991	16	18204	47	C1QC,TREM2,WNT5A,RNASET2,FOLR2,CXCL12,AXL,CSF1R,HAVCR2,CD68,ALPK1,C3AR1,C1QB,MEF2C,C1QA,CH25H
2.242e-05	-10.71	response to oxygen-containing compound	biological process	GO:1901700	1546	14	18204	47	MEF2C,KCNMB1,COL18A1,CD68,HAVCR2,ABCB4,AXL,SPP1,FOLR2,CXCL12,RGS10,WNT5A,TREM2,APOE
2.315e-05	-10.67	sterol metabolic process	biological process	GO:0016125	133	5	18204	47	CH25H,APOC1,OSBPL1A,PPARD,APOE
2.352e-05	-10.66	Complement cascade	REACTOME pathways	R-HSA-166658	45	4	10285	39	C1QC,C3AR1,C1QB,C1QA
2.353e-05	-10.66	negative regulation of lipid localization	biological process	GO:1905953	65	4	18204	47	TREM2,APOC1,APOC2,PPARD
2.720e-05	-10.51	negative regulation of cell population proliferation	biological process	GO:0008285	791	10	18204	47	CSF1R,MEF2C,ADORA3,TREM2,WNT5A,COL18A1,APOE,WDR77,HAVCR2,PPARD
2.914e-05	-10.44	Classical Complement Pathway	SMPDB pathways	SMP0064047	14	3	1369	7	C1QA,C1QC,C1QB
2.944e-05	-10.43	regulation of immune system process	biological process	GO:0002682	1584	14	18204	47	TREM2,WNT5A,C1QC,APOE,CSF1R,AXL,CXCL12,CD68,ALPK1,HAVCR2,C3AR1,C1QA,MEF2C,C1QB
3.066e-05	-10.39	positive regulation of chemotaxis	biological process	GO:0050921	141	5	18204	47	C3AR1,CXCL12,WNT5A,CSF1R,TREM2
3.143e-05	-10.37	plasma lipoprotein particle clearance	biological process	GO:0034381	24	3	18204	47	APOE,APOC2,APOC1
3.195e-05	-10.35	positive regulation of immune response	biological process	GO:0050778	640	9	18204	47	C1QA,MEF2C,TREM2,WNT5A,HAVCR2,C1QC,ALPK1,C1QB,C3AR1
3.280e-05	-10.33	regulation of mononuclear cell migration	biological process	GO:0071675	143	5	18204	47	CXCL12,C3AR1,CSF1R,TREM2,WNT5A
3.853e-05	-10.16	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	2	19108	49	APOC2,APOE
3.856e-05	-10.16	defense response to other organism	biological process	GO:0098542	1006	11	18204	47	C1QC,WNT5A,RNASET2,TREM2,AXL,CSF1R,HAVCR2,ALPK1,C1QB,CH25H,C1QA
3.902e-05	-10.15	cellular response to bile acid	biological process	GO:1903413	4	2	18204	47	ABCB4,KCNMB1
3.902e-05	-10.15	negative regulation of very-low-density lipoprotein particle clearance	biological process	GO:0010916	4	2	18204	47	APOC1,APOC2
3.902e-05	-10.15	complement-mediated synapse pruning	biological process	GO:0150062	4	2	18204	47	TREM2,C1QA
3.953e-05	-10.14	high-density lipoprotein particle	cellular component	GO:0034364	26	3	19108	49	APOC1,APOC2,APOE
3.957e-05	-10.14	cellular response to biotic stimulus	biological process	GO:0071216	247	6	18204	47	CD68,HAVCR2,WNT5A,TREM2,AXL,MEF2C
3.994e-05	-10.13	positive regulation of leukocyte migration	biological process	GO:0002687	149	5	18204	47	WNT5A,TREM2,CSF1R,C3AR1,CXCL12
4.023e-05	-10.12	positive regulation of macrophage migration	biological process	GO:1905523	26	3	18204	47	CSF1R,TREM2,C3AR1
4.085e-05	-10.11	activation of immune response	biological process	GO:0002253	368	7	18204	47	C1QB,MEF2C,C1QA,C1QC,ALPK1,HAVCR2,C3AR1
4.866e-05	-9.93	response to chemical	biological process	GO:0042221	3743	22	18204	47	MEF2C,HAVCR2,CD68,P2RY13,RGS10,FOLR2,CSF1R,ABCB4,TREM2,KCNMB1,CH25H,C3AR1,COL18A1,SPP1,LTC4S,CXCL12,AXL,APOE,PPARD,CSF2RA,WNT5A,PDGFA
5.050e-05	-9.89	purinergic nucleotide receptor signaling pathway	biological process	GO:0035590	28	3	18204	47	ADORA3,P2RY13,GPR34
5.176e-05	-9.87	negative regulation of multicellular organismal process	biological process	GO:0051241	1237	12	18204	47	SPP1,APOC2,AXL,APOE,C1QC,WDR77,TREM2,PDGFA,WNT5A,MEF2C,HAVCR2,APOC1
5.392e-05	-9.83	ITGAV (integrin subunit alpha V)	protein interactions	3685	159	5	19454	50	CSF1R,CXCL12,SPP1,COL18A1,C1QA
5.551e-05	-9.80	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	11	18204	47	WNT5A,TREM2,HAVCR2,CD68,MEF2C,AXL,ABCB4,KCNMB1,RGS10,FOLR2,SPP1
5.562e-05	-9.80	Staphylococcus aureus infection	KEGG pathways	hsa05150	55	4	7161	28	C3AR1,C1QC,C1QA,C1QB
5.562e-05	-9.80	Staphylococcus aureus infection	KEGG pathways	ko05150	55	4	7161	28	C1QB,C1QA,C3AR1,C1QC
5.623e-05	-9.79	cholesterol efflux	biological process	GO:0033344	29	3	18204	47	APOC1,APOE,APOC2
5.641e-05	-9.78	response to lipid	biological process	GO:0033993	862	10	18204	47	TREM2,WNT5A,CD68,HAVCR2,PPARD,ABCB4,AXL,MEF2C,SPP1,KCNMB1
5.786e-05	-9.76	Collagen	interpro domains	IPR008160	78	4	18521	50	COL18A1,C1QC,C1QA,C1QB
5.979e-05	-9.72	positive regulation of catalytic activity	biological process	GO:0043085	868	10	18204	47	APOC2,RGS10,ADORA3,MEF2C,AXL,CSF1R,APOE,PDGFA,WNT5A,TREM2
6.176e-05	-9.69	C1QC (complement C1q C chain)	protein interactions	714	30	3	19454	50	C1QA,COL18A1,C1QB
6.236e-05	-9.68	positive regulation of macrophage activation	biological process	GO:0043032	30	3	18204	47	HAVCR2,TREM2,WNT5A
6.492e-05	-9.64	CXCL12-activated CXCR4 signaling pathway	biological process	GO:0038160	5	2	18204	47	TREM2,CXCL12
6.492e-05	-9.64	regulation of very-low-density lipoprotein particle clearance	biological process	GO:0010915	5	2	18204	47	APOC1,APOC2
6.749e-05	-9.60	Collagen	pfam domains	PF01391	78	4	17795	50	COL18A1,C1QA,C1QB,C1QC
6.892e-05	-9.58	plasma lipoprotein particle remodeling	biological process	GO:0034369	31	3	18204	47	APOC1,APOC2,APOE
6.892e-05	-9.58	protein-lipid complex remodeling	biological process	GO:0034368	31	3	18204	47	APOC2,APOE,APOC1
6.892e-05	-9.58	complement activation, classical pathway	biological process	GO:0006958	31	3	18204	47	C1QA,C1QC,C1QB
6.943e-05	-9.58	collagen trimer	cellular component	GO:0005581	86	4	19108	49	C1QA,COL18A1,C1QC,C1QB
7.092e-05	-9.55	positive regulation of lipid transport	biological process	GO:0032370	86	4	18204	47	TREM2,ABCB4,APOE,SPP1
7.110e-05	-9.55	lipid binding	molecular function	GO:0008289	861	10	18094	48	PPARD,WNT5A,AXL,OSBPL1A,APOC2,APOE,ADAP2,TREM2,LTC4S,APOC1
7.386e-05	-9.51	Initial triggering of complement	REACTOME pathways	R-HSA-166663	22	3	10285	39	C1QC,C1QA,C1QB
7.585e-05	-9.49	cell surface	cellular component	GO:0009986	896	10	19108	49	PDGFA,FOLR2,AXL,TSPAN15,CSF1R,CXCL12,TREM2,HAVCR2,WNT5A,CSF2RA
7.656e-05	-9.48	defense response to symbiont	biological process	GO:0140546	894	10	18204	47	CH25H,CSF1R,AXL,C1QA,C1QB,WNT5A,RNASET2,C1QC,ALPK1,HAVCR2
8.108e-05	-9.42	regulation of leukocyte apoptotic process	biological process	GO:2000106	89	4	18204	47	WNT5A,AXL,MEF2C,CXCL12
8.348e-05	-9.39	negative regulation of epithelial cell proliferation	biological process	GO:0050680	174	5	18204	47	WNT5A,MEF2C,PPARD,WDR77,APOE
8.876e-05	-9.33	C1q	pfam domains	PF00386	31	3	17795	50	C1QC,C1QA,C1QB
9.007e-05	-9.31	Complement Pathway	SMPDB pathways	SMP0063814	20	3	1369	7	C1QC,C1QA,C1QB
9.020e-05	-9.31	amyloid-beta binding	molecular function	GO:0001540	89	4	18094	48	C1QA,APOE,ITM2B,TREM2
9.125e-05	-9.30	regulation of phospholipid metabolic process	biological process	GO:1903725	34	3	18204	47	APOC2,PDGFA,APOC1
9.125e-05	-9.30	protein-containing complex remodeling	biological process	GO:0034367	34	3	18204	47	APOE,APOC2,APOC1
9.126e-05	-9.30	C1Q	smart domains	SM00110	31	3	9717	28	C1QB,C1QC,C1QA
9.227e-05	-9.29	positive regulation of leukocyte chemotaxis	biological process	GO:0002690	92	4	18204	47	WNT5A,CSF1R,C3AR1,CXCL12
9.332e-05	-9.28	response to organic substance	biological process	GO:0010033	2498	17	18204	47	WNT5A,CSF2RA,TREM2,PPARD,CSF1R,ABCB4,AXL,CXCL12,SPP1,FOLR2,RGS10,P2RY13,CD68,HAVCR2,CH25H,MEF2C,KCNMB1
9.540e-05	-9.26	C1q_dom	interpro domains	IPR001073	33	3	18521	50	C1QB,C1QA,C1QC
9.623e-05	-9.25	regulation of extent of cell growth	biological process	GO:0061387	93	4	18204	47	APOE,CXCL12,SPP1,WNT5A
9.722e-05	-9.24	C-X-C chemokine receptor CXCR4 signaling pathway	biological process	GO:0038159	6	2	18204	47	CXCL12,TREM2
9.722e-05	-9.24	negative regulation of phospholipid metabolic process	biological process	GO:1903726	6	2	18204	47	PDGFA,APOC1
9.866e-05	-9.22	regulation of response to external stimulus	biological process	GO:0032101	1116	11	18204	47	C3AR1,ALPK1,HAVCR2,SPP1,CXCL12,CSF1R,PPARD,APOE,WNT5A,PDGFA,TREM2
1.027e-04	-9.18	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	2	18094	48	APOE,APOC1
1.027e-04	-9.18	collagen-containing extracellular matrix	cellular component	GO:0062023	428	7	19108	49	C1QB,APOE,C1QC,WNT5A,COL18A1,CXCL12,C1QA
1.036e-04	-9.17	Complement Activation	WikiPathways	WP545	22	3	5310	23	C1QC,C1QB,C1QA
1.055e-04	-9.16	negative regulation of response to external stimulus	biological process	GO:0032102	428	7	18204	47	APOE,HAVCR2,PPARD,TREM2,PDGFA,WNT5A,SPP1
1.057e-04	-9.15	regulation of endocytosis	biological process	GO:0030100	295	6	18204	47	AXL,APOC2,APOC1,TREM2,WNT5A,APOE
1.066e-04	-9.15	plasma lipoprotein particle	cellular component	GO:0034358	36	3	19108	49	APOC1,APOC2,APOE
1.066e-04	-9.15	lipoprotein particle	cellular component	GO:1990777	36	3	19108	49	APOC2,APOE,APOC1
1.085e-04	-9.13	positive regulation of cholesterol transport	biological process	GO:0032376	36	3	18204	47	ABCB4,TREM2,APOE
1.085e-04	-9.13	humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002455	36	3	18204	47	C1QC,C1QB,C1QA
1.085e-04	-9.13	regulation of lipoprotein particle clearance	biological process	GO:0010984	36	3	18204	47	APOC1,TREM2,APOC2
1.085e-04	-9.13	positive regulation of sterol transport	biological process	GO:0032373	36	3	18204	47	ABCB4,TREM2,APOE
1.111e-04	-9.10	Complement and Coagulation Cascades	WikiPathways	WP558	60	4	5310	23	C1QA,C1QB,C1QC,C3AR1
1.114e-04	-9.10	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051897	185	5	18204	47	PPARD,CSF1R,TREM2,AXL,PDGFA
1.128e-04	-9.09	regulation of cell population proliferation	biological process	GO:0042127	1790	14	18204	47	APOE,WDR77,PPARD,TREM2,PDGFA,WNT5A,CSF2RA,FOLR2,CXCL12,CSF1R,HAVCR2,COL18A1,MEF2C,ADORA3
1.139e-04	-9.08	plasma membrane	cellular component	GO:0005886	5538	27	19108	49	P2RY13,ABCB4,HAVCR2,CSF2RA,DCBLD1,CSF1R,EPB41L2,RGL3,FOLR2,APOE,CD68,ADAP2,WNT5A,SIGLEC8,TREM2,RGS10,ADORA3,ITM2B,OSBPL1A,IFITM10,TSPAN15,CXCL12,ACY3,AXL,C3AR1,GPR34,KCNMB1
1.203e-04	-9.03	regulation of immune response	biological process	GO:0050776	944	10	18204	47	C1QB,C1QA,MEF2C,ALPK1,C1QC,APOE,HAVCR2,C3AR1,TREM2,WNT5A
1.227e-04	-9.01	phospholipid transport	biological process	GO:0015914	99	4	18204	47	ABCB4,APOC1,APOC2,APOE
1.320e-04	-8.93	C1Q	prosite domains	PS50871	33	3	12186	37	C1QB,C1QC,C1QA
1.357e-04	-8.90	protein-lipid complex	cellular component	GO:0032994	39	3	19108	49	APOC1,APOE,APOC2
1.359e-04	-8.90	chemokine (C-X-C motif) ligand 12 signaling pathway	biological process	GO:0038146	7	2	18204	47	CXCL12,TREM2
1.359e-04	-8.90	regulation of phospholipid catabolic process	biological process	GO:0060696	7	2	18204	47	APOC2,APOC1
1.359e-04	-8.90	high-density lipoprotein particle clearance	biological process	GO:0034384	7	2	18204	47	APOE,APOC2
1.359e-04	-8.90	response to bile acid	biological process	GO:1903412	7	2	18204	47	ABCB4,KCNMB1
1.359e-04	-8.90	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	2	18204	47	APOC2,APOE
1.448e-04	-8.84	molecular function activator activity	molecular function	GO:0140677	1132	11	18094	48	RGS10,APOC1,LTC4S,TREM2,ADAP2,APOE,SPP1,APOC2,WNT5A,PDGFA,CXCL12
1.484e-04	-8.82	regulation of chemokine production	biological process	GO:0032642	104	4	18204	47	WNT5A,CSF1R,TREM2,HAVCR2
1.487e-04	-8.81	regulation of developmental growth	biological process	GO:0048638	314	6	18204	47	MEF2C,SPP1,CXCL12,WNT5A,PPARD,APOE
1.525e-04	-8.79	COL6A1 (collagen type VI alpha 1 chain)	protein interactions	1291	105	4	19454	50	PDGFA,WNT5A,C1QC,COL18A1
1.568e-04	-8.76	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	5	18204	47	HAVCR2,APOE,TREM2,CSF1R,PDGFA
1.640e-04	-8.72	regulation of catalytic activity	biological process	GO:0050790	1395	12	18204	47	APOE,WNT5A,PDGFA,APOC1,TREM2,APOC2,RGS10,ADORA3,ADAP2,MEF2C,AXL,CSF1R
1.704e-04	-8.68	alcohol metabolic process	biological process	GO:0006066	322	6	18204	47	APOE,PPARD,OSBPL1A,APOC1,CH25H,DHRS9
1.739e-04	-8.66	cellular response to organic cyclic compound	biological process	GO:0071407	464	7	18204	47	PPARD,P2RY13,SPP1,FOLR2,KCNMB1,ABCB4,MEF2C
1.806e-04	-8.62	positive regulation of cell population proliferation	biological process	GO:0008284	992	10	18204	47	CSF1R,MEF2C,FOLR2,CXCL12,WNT5A,PDGFA,CSF2RA,WDR77,HAVCR2,PPARD
1.809e-04	-8.62	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	2	18204	47	TREM2,APOE
1.809e-04	-8.62	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	2	18204	47	APOC2,APOE
1.888e-04	-8.57	human chr1p36.12	chromosome location	human chr1p36.12	58	3	26134	50	C1QC,C1QB,C1QA
1.908e-04	-8.56	positive regulation of lipid localization	biological process	GO:1905954	111	4	18204	47	SPP1,APOE,ABCB4,TREM2
1.927e-04	-8.55	cellular response to lipopolysaccharide	biological process	GO:0071222	208	5	18204	47	HAVCR2,CD68,WNT5A,MEF2C,AXL
1.957e-04	-8.54	positive regulation of MAPK cascade	biological process	GO:0043410	473	7	18204	47	MEF2C,CSF1R,HAVCR2,APOE,PDGFA,WNT5A,TREM2
1.971e-04	-8.53	regulation of chemotaxis	biological process	GO:0050920	209	5	18204	47	CXCL12,C3AR1,CSF1R,TREM2,WNT5A
1.979e-04	-8.53	regulation of small molecule metabolic process	biological process	GO:0062012	331	6	18204	47	CH25H,APOC2,APOC1,TREM2,APOE,PPARD
2.044e-04	-8.50	synapse organization	biological process	GO:0050808	333	6	18204	47	WNT5A,TREM2,C1QA,C1QB,APOE,C1QC
2.044e-04	-8.50	response to lipopolysaccharide	biological process	GO:0032496	333	6	18204	47	WNT5A,TREM2,CD68,HAVCR2,AXL,MEF2C
2.121e-04	-8.46	regulation of macrophage migration	biological process	GO:1905521	45	3	18204	47	C3AR1,TREM2,CSF1R
2.199e-04	-8.42	negative regulation of cell activation	biological process	GO:0050866	214	5	18204	47	PDGFA,TREM2,AXL,APOE,HAVCR2
2.265e-04	-8.39	plasma lipoprotein particle organization	biological process	GO:0071827	46	3	18204	47	APOE,APOC2,APOC1
2.297e-04	-8.38	Complement and coagulation cascades	KEGG pathways	ko04610	79	4	7161	28	C1QB,C1QA,C1QC,C3AR1
2.297e-04	-8.38	Complement and coagulation cascades	KEGG pathways	hsa04610	79	4	7161	28	C1QA,C3AR1,C1QC,C1QB
2.322e-04	-8.37	microglial cell proliferation	biological process	GO:0061518	9	2	18204	47	CSF1R,TREM2
2.322e-04	-8.37	negative regulation of dendritic cell apoptotic process	biological process	GO:2000669	9	2	18204	47	CXCL12,AXL
2.322e-04	-8.37	macrophage proliferation	biological process	GO:0061517	9	2	18204	47	CSF1R,TREM2
2.474e-04	-8.30	chemotaxis	biological process	GO:0006935	345	6	18204	47	CH25H,WNT5A,PDGFA,C3AR1,CXCL12,FOLR2
2.552e-04	-8.27	taxis	biological process	GO:0042330	347	6	18204	47	C3AR1,CXCL12,FOLR2,WNT5A,PDGFA,CH25H
2.734e-04	-8.20	protein-lipid complex organization	biological process	GO:0071825	49	3	18204	47	APOC1,APOC2,APOE
2.734e-04	-8.20	complement activation	biological process	GO:0006956	49	3	18204	47	C1QA,C1QC,C1QB
2.741e-04	-8.20	regulation of leukocyte chemotaxis	biological process	GO:0002688	122	4	18204	47	WNT5A,CSF1R,C3AR1,CXCL12
2.817e-04	-8.17	positive regulation of intracellular signal transduction	biological process	GO:1902533	1048	10	18204	47	AXL,MEF2C,CSF1R,PPARD,HAVCR2,APOE,ALPK1,PDGFA,WNT5A,TREM2
2.840e-04	-8.17	response to molecule of bacterial origin	biological process	GO:0002237	354	6	18204	47	MEF2C,AXL,HAVCR2,CD68,TREM2,WNT5A
2.845e-04	-8.16	phospholipid binding	molecular function	GO:0005543	489	7	18094	48	APOC1,TREM2,APOE,ADAP2,WNT5A,OSBPL1A,AXL
2.874e-04	-8.15	COMPLEMNTC1Q	prints domains	PR00007	29	3	5227	24	C1QA,C1QC,C1QB
2.898e-04	-8.15	regulation of behavioral fear response	biological process	GO:2000822	10	2	18204	47	MEF2C,APOE
2.898e-04	-8.15	regulation of fat cell proliferation	biological process	GO:0070344	10	2	18204	47	TREM2,PPARD
2.898e-04	-8.15	vagina development	biological process	GO:0060068	10	2	18204	47	WNT5A,AXL
3.131e-04	-8.07	regulation of leukocyte migration	biological process	GO:0002685	231	5	18204	47	CSF1R,TREM2,WNT5A,CXCL12,C3AR1
3.223e-04	-8.04	Prion diseases	KEGG pathways	ko05020	35	3	7161	28	C1QA,C1QC,C1QB
3.223e-04	-8.04	Prion diseases	KEGG pathways	hsa05020	35	3	7161	28	C1QB,C1QA,C1QC
3.444e-04	-7.97	locomotion	biological process	GO:0040011	367	6	18204	47	FOLR2,CXCL12,CH25H,C3AR1,PDGFA,WNT5A
3.536e-04	-7.95	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	2	18204	47	APOE,CH25H
3.536e-04	-7.95	negative regulation of cholesterol storage	biological process	GO:0010887	11	2	18204	47	PPARD,TREM2
3.536e-04	-7.95	regulation of fear response	biological process	GO:1903365	11	2	18204	47	MEF2C,APOE
3.536e-04	-7.95	secondary heart field specification	biological process	GO:0003139	11	2	18204	47	MEF2C,WNT5A
3.559e-04	-7.94	Statin Pathway	WikiPathways	WP430	33	3	5310	23	APOC1,APOC2,APOE
3.587e-04	-7.93	molecular transducer activity	molecular function	GO:0060089	1474	12	18094	48	FOLR2,DCBLD1,GPR34,P2RY13,AXL,ADORA3,C3AR1,TREM2,SIGLEC8,CSF1R,CSF2RA,PPARD
3.587e-04	-7.93	signaling receptor activity	molecular function	GO:0038023	1474	12	18094	48	FOLR2,DCBLD1,GPR34,P2RY13,ADORA3,AXL,C3AR1,TREM2,SIGLEC8,PPARD,CSF1R,CSF2RA
3.857e-04	-7.86	positive regulation of response to stimulus	biological process	GO:0048584	2266	15	18204	47	WNT5A,PDGFA,TREM2,PPARD,APOE,C1QC,CSF1R,AXL,CXCL12,C3AR1,ALPK1,HAVCR2,MEF2C,C1QA,C1QB
3.944e-04	-7.84	Tumour_necrosis_fac-like_dom	interpro domains	IPR008983	53	3	18521	50	C1QB,C1QA,C1QC
3.993e-04	-7.83	cell junction organization	biological process	GO:0034330	532	7	18204	47	C1QC,APOE,TREM2,WNT5A,C1QB,CSF1R,C1QA
4.184e-04	-7.78	response to stimulus	biological process	GO:0050896	7803	32	18204	47	C3AR1,RGL3,COL18A1,KCNMB1,C1QB,SIGLEC8,C1QA,CH25H,C1QC,APOE,PPARD,CSF2RA,WNT5A,PDGFA,SPP1,CXCL12,LTC4S,AXL,HAVCR2,ALPK1,CD68,USP53,P2RY13,GPR34,MEF2C,ADORA3,TREM2,RNASET2,RGS10,FOLR2,CSF1R,ABCB4
4.203e-04	-7.77	positive regulation of transferase activity	biological process	GO:0051347	381	6	18204	47	AXL,CSF1R,TREM2,PDGFA,WNT5A,APOE
4.206e-04	-7.77	regulation of localization	biological process	GO:0032879	2028	14	18204	47	APOC1,MEF2C,ADORA3,KCNMB1,TREM2,WNT5A,APOE,PPARD,ABCB4,AXL,SPP1,CXCL12,EPB41L2,APOC2
4.236e-04	-7.77	response to macrophage colony-stimulating factor	biological process	GO:0036005	12	2	18204	47	SPP1,CSF1R
4.236e-04	-7.77	heart field specification	biological process	GO:0003128	12	2	18204	47	WNT5A,MEF2C
4.236e-04	-7.77	regulation of dendritic cell apoptotic process	biological process	GO:2000668	12	2	18204	47	CXCL12,AXL
4.239e-04	-7.77	COL2A1 (collagen type II alpha 1 chain)	protein interactions	1280	57	3	19454	50	PDGFA,C1QA,C1QC
4.255e-04	-7.76	humoral immune response	biological process	GO:0006959	247	5	18204	47	C1QB,C1QC,TREM2,C1QA,MEF2C
4.381e-04	-7.73	regulation of multicellular organismal process	biological process	GO:0051239	3113	18	18204	47	AXL,CSF1R,APOC2,SPP1,CXCL12,WNT5A,PDGFA,TREM2,PPARD,C1QC,APOE,WDR77,ADORA3,MEF2C,APOC1,C3AR1,HAVCR2,BHLHE41
4.505e-04	-7.71	maternal process involved in female pregnancy	biological process	GO:0060135	58	3	18204	47	PPARD,SPP1,HAVCR2
4.738e-04	-7.65	regulation of plasma lipoprotein particle levels	biological process	GO:0097006	59	3	18204	47	APOC1,APOC2,APOE
4.879e-04	-7.63	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	4	18204	47	TREM2,APOE,APOC2,PPARD
4.978e-04	-7.61	regulation of macrophage activation	biological process	GO:0043030	60	3	18204	47	TREM2,WNT5A,HAVCR2
4.978e-04	-7.61	positive regulation of cytokine-mediated signaling pathway	biological process	GO:0001961	60	3	18204	47	TREM2,AXL,WNT5A
4.998e-04	-7.60	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	2	18204	47	APOE,TREM2
4.998e-04	-7.60	G protein-coupled purinergic nucleotide receptor signaling pathway	biological process	GO:0035589	13	2	18204	47	GPR34,P2RY13
5.225e-04	-7.56	-	gene3d domains	2.60.120.40	52	3	14470	44	C1QA,C1QC,C1QB
5.225e-04	-7.56	extracellular matrix	cellular component	GO:0031012	559	7	19108	49	C1QB,C1QA,WNT5A,COL18A1,C1QC,APOE,CXCL12
5.276e-04	-7.55	G protein-coupled purinergic nucleotide receptor activity	molecular function	GO:0045028	13	2	18094	48	GPR34,P2RY13
5.281e-04	-7.55	external encapsulating structure	cellular component	GO:0030312	560	7	19108	49	CXCL12,C1QC,APOE,C1QA,COL18A1,WNT5A,C1QB
5.482e-04	-7.51	macrophage activation	biological process	GO:0042116	62	3	18204	47	C1QA,TREM2,HAVCR2
5.483e-04	-7.51	amide binding	molecular function	GO:0033218	254	5	18094	48	C1QA,APOE,ITM2B,TREM2,FOLR2
5.661e-04	-7.48	positive regulation of response to external stimulus	biological process	GO:0032103	564	7	18204	47	ALPK1,HAVCR2,C3AR1,TREM2,WNT5A,CXCL12,CSF1R
5.691e-04	-7.47	PTX3 (pentraxin 3)	protein interactions	5806	63	3	19454	50	C1QB,C1QA,C1QC
5.821e-04	-7.45	positive regulation of phospholipid transport	biological process	GO:2001140	14	2	18204	47	ABCB4,APOE
5.821e-04	-7.45	cellular response to oxidised low-density lipoprotein particle stimulus	biological process	GO:0140052	14	2	18204	47	CD68,TREM2
5.821e-04	-7.45	regulation of lipoprotein lipase activity	biological process	GO:0051004	14	2	18204	47	APOC2,APOC1
6.237e-04	-7.38	COLGALT2 (collagen beta(1-O)galactosyltransferase 2)	protein interactions	23127	65	3	19454	50	C1QA,COL18A1,C1QB
6.377e-04	-7.36	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	biological process	GO:0051896	270	5	18204	47	PPARD,AXL,TREM2,CSF1R,PDGFA
6.461e-04	-7.34	organophosphate ester transport	biological process	GO:0015748	153	4	18204	47	APOC2,APOE,APOC1,ABCB4
6.537e-04	-7.33	regulation of transport	biological process	GO:0051049	1621	12	18204	47	APOC1,KCNMB1,MEF2C,ADORA3,APOE,TREM2,WNT5A,CXCL12,SPP1,APOC2,ABCB4,AXL
6.586e-04	-7.33	response to ischemia	biological process	GO:0002931	66	3	18204	47	CSF1R,TREM2,MEF2C
6.593e-04	-7.32	regulation of epithelial cell proliferation	biological process	GO:0050678	415	6	18204	47	WDR77,CXCL12,APOE,PPARD,MEF2C,WNT5A
6.622e-04	-7.32	low-density lipoprotein particle	cellular component	GO:0034362	15	2	19108	49	APOC2,APOE
6.654e-04	-7.32	C1R (complement C1r)	protein interactions	715	15	2	19454	50	C1QB,C1QA
6.706e-04	-7.31	regulation of phospholipid transport	biological process	GO:2001138	15	2	18204	47	APOE,ABCB4
6.882e-04	-7.28	cholesterol transport	biological process	GO:0030301	67	3	18204	47	APOC1,APOE,APOC2
6.882e-04	-7.28	positive regulation of response to cytokine stimulus	biological process	GO:0060760	67	3	18204	47	AXL,TREM2,WNT5A
7.117e-04	-7.25	positive regulation of endocytosis	biological process	GO:0045807	157	4	18204	47	APOE,AXL,TREM2,WNT5A
7.186e-04	-7.24	negative regulation of lipid biosynthetic process	biological process	GO:0051055	68	3	18204	47	APOE,PDGFA,APOC1
7.651e-04	-7.18	regulation of axon extension involved in axon guidance	biological process	GO:0048841	16	2	18204	47	WNT5A,CXCL12
7.747e-04	-7.16	C1QA (complement C1q A chain)	protein interactions	712	70	3	19454	50	C1QB,C1QC,WNT5A
7.787e-04	-7.16	positive regulation of molecular function	biological process	GO:0044093	1192	10	18204	47	ADORA3,AXL,MEF2C,CSF1R,APOC2,RGS10,WNT5A,PDGFA,TREM2,APOE
8.032e-04	-7.13	response to wounding	biological process	GO:0009611	431	6	18204	47	WNT5A,ADORA3,PDGFA,TREM2,AXL,PPARD
8.076e-04	-7.12	lipase inhibitor activity	molecular function	GO:0055102	16	2	18094	48	APOC1,APOC2
8.377e-04	-7.08	positive regulation of leukocyte proliferation	biological process	GO:0070665	164	4	18204	47	MEF2C,CSF1R,CSF2RA,HAVCR2
8.410e-04	-7.08	NDUFC2 (NADH:ubiquinone oxidoreductase subunit C2)	protein interactions	4718	72	3	19454	50	TSPAN15,C3AR1,GPR34
8.491e-04	-7.07	positive regulation of chemokine production	biological process	GO:0032722	72	3	18204	47	HAVCR2,CSF1R,WNT5A
8.561e-04	-7.06	human chr19q13.32	chromosome location	human chr19q13.32	97	3	26134	50	APOC1,APOE,APOC2
8.657e-04	-7.05	regulation of amyloid fibril formation	biological process	GO:1905906	17	2	18204	47	TREM2,APOE
8.657e-04	-7.05	reverse cholesterol transport	biological process	GO:0043691	17	2	18204	47	APOC2,APOE
8.657e-04	-7.05	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	2	18204	47	APOE,APOC1
8.657e-04	-7.05	specification of animal organ identity	biological process	GO:0010092	17	2	18204	47	MEF2C,WNT5A
8.754e-04	-7.04	GAS6 (growth arrest specific 6)	protein interactions	2621	73	3	19454	50	C1QB,AXL,WNT5A
9.140e-04	-7.00	lipid metabolic process	biological process	GO:0006629	1217	10	18204	47	APOC1,DHRS9,APOE,PPARD,ABCB4,CH25H,SPP1,LTC4S,APOC2,OSBPL1A
9.195e-04	-6.99	sterol transport	biological process	GO:0015918	74	3	18204	47	APOC2,APOE,APOC1
9.470e-04	-6.96	CRP (C-reactive protein)	protein interactions	1401	75	3	19454	50	COL18A1,C1QA,HS3ST1
9.494e-04	-6.96	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	5	18204	47	PDGFA,CSF1R,TREM2,APOE,HAVCR2
9.525e-04	-6.96	enzyme activator activity	molecular function	GO:0008047	599	7	18094	48	APOE,ADAP2,APOC1,TREM2,LTC4S,APOC2,RGS10
9.723e-04	-6.94	negative regulation of platelet activation	biological process	GO:0010544	18	2	18204	47	PDGFA,APOE
9.723e-04	-6.94	heart formation	biological process	GO:0060914	18	2	18204	47	WNT5A,MEF2C
9.936e-04	-6.91	regulation of axon extension	biological process	GO:0030516	76	3	18204	47	WNT5A,APOE,CXCL12
1.022e-03	-6.89	regulation of cell size	biological process	GO:0008361	173	4	18204	47	WNT5A,APOE,CXCL12,SPP1
1.040e-03	-6.87	cell junction	cellular component	GO:0030054	2224	14	19108	49	MEF2C,APOE,EPB41L2,TSPAN15,KCNMB1,C1QA,WNT5A,ABCB4,RGS10,USP53,C1QC,C1QB,ADORA3,HAVCR2
1.054e-03	-6.86	positive regulation of kinase activity	biological process	GO:0033674	302	5	18204	47	CSF1R,TREM2,AXL,WNT5A,PDGFA
1.066e-03	-6.84	epithelial cell proliferation	biological process	GO:0050673	175	4	18204	47	WDR77,PPARD,MEF2C,WNT5A
1.071e-03	-6.84	negative regulation of tumor necrosis factor production	biological process	GO:0032720	78	3	18204	47	AXL,TREM2,HAVCR2
1.081e-03	-6.83	Differentiation Pathway	WikiPathways	WP2848	48	3	5310	23	PDGFA,WNT5A,CSF1R
1.085e-03	-6.83	regulation of cholesterol storage	biological process	GO:0010885	19	2	18204	47	TREM2,PPARD
1.085e-03	-6.83	positive regulation of macrophage chemotaxis	biological process	GO:0010759	19	2	18204	47	CSF1R,C3AR1
1.085e-03	-6.83	macrophage activation involved in immune response	biological process	GO:0002281	19	2	18204	47	TREM2,HAVCR2
1.085e-03	-6.83	female genitalia development	biological process	GO:0030540	19	2	18204	47	WNT5A,AXL
1.085e-03	-6.83	regulation of amyloid-beta clearance	biological process	GO:1900221	19	2	18204	47	TREM2,APOE
1.085e-03	-6.83	notochord development	biological process	GO:0030903	19	2	18204	47	WNT5A,COL18A1
1.085e-03	-6.83	astrocyte activation	biological process	GO:0048143	19	2	18204	47	C1QA,TREM2
1.085e-03	-6.83	regulation of cell activation	biological process	GO:0050865	630	7	18204	47	WNT5A,PDGFA,TREM2,HAVCR2,APOE,MEF2C,AXL
1.089e-03	-6.82	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002460	176	4	18204	47	C1QC,C1QB,C1QA,MEF2C
1.153e-03	-6.77	negative regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903556	80	3	18204	47	HAVCR2,TREM2,AXL
1.159e-03	-6.76	lipid homeostasis	biological process	GO:0055088	179	4	18204	47	APOC2,APOE,ABCB4,TREM2
1.203e-03	-6.72	regulation of antigen processing and presentation	biological process	GO:0002577	20	2	18204	47	CD68,TREM2
1.205e-03	-6.72	response to cytokine	biological process	GO:0034097	834	8	18204	47	CSF2RA,WNT5A,TREM2,CH25H,AXL,CSF1R,SPP1,CXCL12
1.252e-03	-6.68	regulation of cell development	biological process	GO:0060284	839	8	18204	47	SPP1,CXCL12,AXL,MEF2C,C1QC,BHLHE41,WNT5A,TREM2
1.270e-03	-6.67	nucleotide receptor activity	molecular function	GO:0016502	20	2	18094	48	GPR34,P2RY13
1.270e-03	-6.67	purinergic nucleotide receptor activity	molecular function	GO:0001614	20	2	18094	48	GPR34,P2RY13
1.295e-03	-6.65	regulation of molecular function	biological process	GO:0065009	2005	13	18204	47	ADAP2,ADORA3,MEF2C,HAVCR2,APOC1,APOC2,RGS10,AXL,CSF1R,APOE,WNT5A,PDGFA,TREM2
1.301e-03	-6.64	positive regulation of transport	biological process	GO:0051050	844	8	18204	47	KCNMB1,SPP1,CXCL12,AXL,ABCB4,APOE,WNT5A,TREM2
1.328e-03	-6.62	positive regulation by host of viral process	biological process	GO:0044794	21	2	18204	47	APOE,CSF1R
1.328e-03	-6.62	negative regulation of lipoprotein particle clearance	biological process	GO:0010985	21	2	18204	47	APOC1,APOC2
1.336e-03	-6.62	regulation of endothelial cell proliferation	biological process	GO:0001936	186	4	18204	47	MEF2C,WNT5A,CXCL12,APOE
1.374e-03	-6.59	regulation of cell migration	biological process	GO:0030334	1061	9	18204	47	CXCL12,ADORA3,CSF1R,MEF2C,C3AR1,APOE,PDGFA,WNT5A,TREM2
1.384e-03	-6.58	extracellular region	cellular component	GO:0005576	4350	21	19108	49	C1QC,ABCB4,APOC2,CSF2RA,APOC1,COL18A1,OSBPL1A,SPP1,ITM2B,C1QB,RNASET2,ACY3,EPB41L2,AXL,CXCL12,PDGFA,APOE,FOLR2,TREM2,C1QA,WNT5A
1.384e-03	-6.58	organic hydroxy compound metabolic process	biological process	GO:1901615	479	6	18204	47	APOC1,CH25H,DHRS9,APOE,PPARD,OSBPL1A
1.417e-03	-6.56	regulation of tumor necrosis factor production	biological process	GO:0032680	189	4	18204	47	WNT5A,TREM2,AXL,HAVCR2
1.417e-03	-6.56	regulation of lipid biosynthetic process	biological process	GO:0046890	189	4	18204	47	APOC2,APOE,PDGFA,APOC1
1.447e-03	-6.54	TPRG1 (tumor protein p63 regulated 1)	protein interactions	285386	22	2	19454	50	APOC1,APOC2
1.447e-03	-6.54	RSAD2 (radical S-adenosyl methionine domain containing 2)	protein interactions	91543	22	2	19454	50	APOC2,APOC1
1.455e-03	-6.53	C1QB (complement C1q B chain)	protein interactions	713	87	3	19454	50	COL18A1,C1QA,C1QC
1.458e-03	-6.53	negative regulation of lipid storage	biological process	GO:0010888	22	2	18204	47	TREM2,PPARD
1.535e-03	-6.48	regulation of MAPK cascade	biological process	GO:0043408	669	7	18204	47	APOE,HAVCR2,TREM2,PDGFA,WNT5A,CSF1R,MEF2C
1.552e-03	-6.47	endoplasmic reticulum	cellular component	GO:0005783	2051	13	19108	49	WNT5A,DHRS9,CH25H,APOE,PDGFA,TSPAN15,RNASET2,LTC4S,SPP1,OSBPL1A,COL18A1,APOC1,P2RY13
1.589e-03	-6.44	regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903555	195	4	18204	47	WNT5A,TREM2,AXL,HAVCR2
1.626e-03	-6.42	Nucleotide-like (purinergic) receptors	REACTOME pathways	R-HSA-418038	16	2	10285	39	ADORA3,P2RY13
1.708e-03	-6.37	APOA2 (apolipoprotein A2)	protein interactions	336	92	3	19454	50	TREM2,APOC2,APOC1
1.737e-03	-6.36	plasma lipoprotein particle assembly	biological process	GO:0034377	24	2	18204	47	APOC1,APOE
1.756e-03	-6.34	lipid transport	biological process	GO:0006869	339	5	18204	47	APOC1,ABCB4,PPARD,APOC2,APOE
1.757e-03	-6.34	carboxylic acid binding	molecular function	GO:0031406	195	4	18094	48	SIGLEC8,FOLR2,APOC1,PPARD
1.885e-03	-6.27	decidualization	biological process	GO:0046697	25	2	18204	47	SPP1,PPARD
1.885e-03	-6.27	steroid catabolic process	biological process	GO:0006706	25	2	18204	47	APOE,SPP1
1.913e-03	-6.26	human chr6q23.1-q23.2	chromosome location	human chr6q23.1-q23.2	1	1	26134	50	EPB41L2
1.939e-03	-6.25	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	7	18204	47	AXL,MEF2C,CSF1R,APOC2,TREM2,WNT5A,PDGFA
1.939e-03	-6.25	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	7	18204	47	TREM2,WNT5A,PDGFA,APOC2,MEF2C,AXL,CSF1R
1.948e-03	-6.24	negative regulation of response to wounding	biological process	GO:1903035	96	3	18204	47	PDGFA,SPP1,APOE
1.948e-03	-6.24	immunoglobulin mediated immune response	biological process	GO:0016064	96	3	18204	47	C1QB,C1QC,C1QA
2.018e-03	-6.21	regulation of vesicle-mediated transport	biological process	GO:0060627	516	6	18204	47	TREM2,APOC1,WNT5A,APOE,AXL,APOC2
2.023e-03	-6.20	regulation of cell motility	biological process	GO:2000145	1122	9	18204	47	CXCL12,CSF1R,MEF2C,ADORA3,APOE,C3AR1,TREM2,PDGFA,WNT5A
2.038e-03	-6.20	positive regulation of mesenchymal cell proliferation	biological process	GO:0002053	26	2	18204	47	PDGFA,WNT5A
2.047e-03	-6.19	SLC7A2 (solute carrier family 7 member 2)	protein interactions	6542	98	3	19454	50	C3AR1,TSPAN15,ANKRD22
2.073e-03	-6.18	G alpha (i) signalling events	REACTOME pathways	R-HSA-418594	242	5	10285	39	RGS10,ADORA3,C3AR1,CXCL12,P2RY13
2.107e-03	-6.16	DEFA1 (defensin alpha 1)	protein interactions	1667	99	3	19454	50	COL18A1,C1QB,WNT5A
2.127e-03	-6.15	regulation of fatty acid metabolic process	biological process	GO:0019217	99	3	18204	47	PPARD,APOC2,APOC1
2.136e-03	-6.15	negative regulation of cellular component organization	biological process	GO:0051129	709	7	18204	47	CH25H,SPP1,APOC2,TREM2,APOC1,WNT5A,APOE
2.181e-03	-6.13	NSG2 (neuronal vesicle trafficking associated 2)	protein interactions	51617	27	2	19454	50	APOC1,ITM2B
2.184e-03	-6.13	organic acid binding	molecular function	GO:0043177	207	4	18094	48	PPARD,APOC1,FOLR2,SIGLEC8
2.198e-03	-6.12	positive regulation of leukocyte apoptotic process	biological process	GO:2000108	27	2	18204	47	MEF2C,WNT5A
2.198e-03	-6.12	positive regulation of cholesterol efflux	biological process	GO:0010875	27	2	18204	47	APOE,TREM2
2.198e-03	-6.12	regulation of membrane protein ectodomain proteolysis	biological process	GO:0051043	27	2	18204	47	APOE,TSPAN15
2.198e-03	-6.12	protein-lipid complex assembly	biological process	GO:0065005	27	2	18204	47	APOC1,APOE
2.252e-03	-6.10	B cell mediated immunity	biological process	GO:0019724	101	3	18204	47	C1QB,C1QC,C1QA
2.286e-03	-6.08	negative regulation of immune system process	biological process	GO:0002683	529	6	18204	47	TREM2,AXL,C1QC,CXCL12,CD68,HAVCR2
2.330e-03	-6.06	regulation of kinase activity	biological process	GO:0043549	531	6	18204	47	WNT5A,PDGFA,TREM2,APOE,AXL,CSF1R
2.338e-03	-6.06	positive regulation of leukocyte activation	biological process	GO:0002696	362	5	18204	47	WNT5A,TREM2,AXL,MEF2C,HAVCR2
2.347e-03	-6.05	molecular function regulator activity	molecular function	GO:0098772	2079	13	18094	48	RGL3,TREM2,LTC4S,APOC1,RGS10,SPP1,APOE,ADAP2,PDGFA,WNT5A,APOC2,CXCL12,KCNMB1
2.363e-03	-6.05	regulation of macrophage chemotaxis	biological process	GO:0010758	28	2	18204	47	C3AR1,CSF1R
2.363e-03	-6.05	glial cell proliferation	biological process	GO:0014009	28	2	18204	47	CSF1R,TREM2
2.366e-03	-6.05	adaptive immune response	biological process	GO:0002250	363	5	18204	47	C1QA,MEF2C,C1QB,HAVCR2,C1QC
2.413e-03	-6.03	human chr10q23.31	chromosome location	human chr10q23.31	38	2	26134	50	CH25H,ANKRD22
2.451e-03	-6.01	regulation of phosphate metabolic process	biological process	GO:0019220	1154	9	18204	47	TREM2,APOC1,PDGFA,WNT5A,APOE,MEF2C,AXL,CSF1R,APOC2
2.465e-03	-6.01	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	9	18204	47	AXL,MEF2C,CSF1R,APOC2,PDGFA,WNT5A,TREM2,APOC1,APOE
2.472e-03	-6.00	Golgi lumen	cellular component	GO:0005796	105	3	19108	49	PDGFA,HS3ST1,WNT5A
2.503e-03	-5.99	modified amino acid binding	molecular function	GO:0072341	102	3	18094	48	FOLR2,TREM2,AXL
2.514e-03	-5.99	MMP10 (matrix metallopeptidase 10)	protein interactions	4319	29	2	19454	50	HS3ST1,APOE
2.534e-03	-5.98	androgen metabolic process	biological process	GO:0008209	29	2	18204	47	SPP1,DHRS9
2.550e-03	-5.97	HDL-mediated lipid transport	REACTOME pathways	R-HSA-194223	20	2	10285	39	APOC2,APOE
2.559e-03	-5.97	USP30 (ubiquitin specific peptidase 30)	protein interactions	84749	106	3	19454	50	C1QA,C1QC,C1QB
2.570e-03	-5.96	LPL (lipoprotein lipase)	protein interactions	280843	1	1	19454	50	APOC2
2.582e-03	-5.96	regulation of collateral sprouting of intact axon in response to injury	biological process	GO:0048683	1	1	18204	47	SPP1
2.582e-03	-5.96	positive regulation of CD40 signaling pathway	biological process	GO:2000350	1	1	18204	47	TREM2
2.582e-03	-5.96	planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	biological process	GO:0061350	1	1	18204	47	WNT5A
2.582e-03	-5.96	planar cell polarity pathway involved in ventricular septum morphogenesis	biological process	GO:0061348	1	1	18204	47	WNT5A
2.582e-03	-5.96	negative regulation of cell proliferation in midbrain	biological process	GO:1904934	1	1	18204	47	WNT5A
2.582e-03	-5.96	planar cell polarity pathway involved in cardiac right atrium morphogenesis	biological process	GO:0061349	1	1	18204	47	WNT5A
2.582e-03	-5.96	negative regulation of interleukin-3 production	biological process	GO:0032712	1	1	18204	47	HAVCR2
2.582e-03	-5.96	positive regulation of synapse pruning	biological process	GO:1905808	1	1	18204	47	TREM2
2.582e-03	-5.96	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	47	APOE
2.582e-03	-5.96	regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	biological process	GO:0060683	1	1	18204	47	PDGFA
2.582e-03	-5.96	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	47	APOE
2.582e-03	-5.96	non-canonical Wnt signaling pathway involved in heart development	biological process	GO:0061341	1	1	18204	47	WNT5A
2.582e-03	-5.96	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	47	APOE
2.582e-03	-5.96	planar cell polarity pathway involved in heart morphogenesis	biological process	GO:0061346	1	1	18204	47	WNT5A
2.582e-03	-5.96	excitatory synapse pruning	biological process	GO:1905805	1	1	18204	47	TREM2
2.582e-03	-5.96	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	47	APOE
2.582e-03	-5.96	sinoatrial valve morphogenesis	biological process	GO:0003185	1	1	18204	47	MEF2C
2.582e-03	-5.96	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	47	APOE
2.582e-03	-5.96	positive regulation of complement activation, classical pathway	biological process	GO:0045960	1	1	18204	47	TREM2
2.582e-03	-5.96	negative regulation of collateral sprouting of intact axon in response to injury	biological process	GO:0048685	1	1	18204	47	SPP1
2.582e-03	-5.96	negative regulation of granulocyte colony-stimulating factor production	biological process	GO:0071656	1	1	18204	47	HAVCR2
2.582e-03	-5.96	positive regulation of CAMKK-AMPK signaling cascade	biological process	GO:1905291	1	1	18204	47	TREM2
2.582e-03	-5.96	negative regulation of fusion of virus membrane with host plasma membrane	biological process	GO:1903914	1	1	18204	47	CH25H
2.582e-03	-5.96	regulation of fusion of virus membrane with host plasma membrane	biological process	GO:1903913	1	1	18204	47	CH25H
2.582e-03	-5.96	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	47	APOE
2.582e-03	-5.96	regulation of C-C chemokine receptor CCR7 signaling pathway	biological process	GO:1903080	1	1	18204	47	TREM2
2.582e-03	-5.96	detection of lipoteichoic acid	biological process	GO:0070392	1	1	18204	47	TREM2
2.582e-03	-5.96	planar cell polarity pathway involved in outflow tract morphogenesis	biological process	GO:0061347	1	1	18204	47	WNT5A
2.582e-03	-5.96	positive regulation of C-C chemokine receptor CCR7 signaling pathway	biological process	GO:1903082	1	1	18204	47	TREM2
2.582e-03	-5.96	chemoattraction of serotonergic neuron axon	biological process	GO:0036517	1	1	18204	47	WNT5A
2.582e-03	-5.96	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	47	APOE
2.582e-03	-5.96	Wnt signaling pathway involved in heart development	biological process	GO:0003306	1	1	18204	47	WNT5A
2.582e-03	-5.96	regulation of toll-like receptor 6 signaling pathway	biological process	GO:0034151	1	1	18204	47	TREM2
2.582e-03	-5.96	planar cell polarity pathway involved in pericardium morphogenesis	biological process	GO:0061354	1	1	18204	47	WNT5A
2.582e-03	-5.96	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	47	APOE
2.582e-03	-5.96	negative regulation of phosphatidylcholine catabolic process	biological process	GO:0010900	1	1	18204	47	APOC1
2.599e-03	-5.95	regulation of locomotion	biological process	GO:0040012	1164	9	18204	47	TREM2,PDGFA,WNT5A,APOE,C3AR1,CSF1R,MEF2C,ADORA3,CXCL12
2.653e-03	-5.93	linoleic acid binding	molecular function	GO:0070539	1	1	18094	48	PPARD
2.653e-03	-5.93	ribonuclease T2 activity	molecular function	GO:0033897	1	1	18094	48	RNASET2
2.653e-03	-5.93	cholesterol 25-hydroxylase activity	molecular function	GO:0001567	1	1	18094	48	CH25H
2.653e-03	-5.93	receptor tyrosine kinase-like orphan receptor binding	molecular function	GO:0005115	1	1	18094	48	WNT5A
2.653e-03	-5.93	metal chelating activity	molecular function	GO:0046911	1	1	18094	48	APOE
2.653e-03	-5.93	complement component C3a receptor activity	molecular function	GO:0004876	1	1	18094	48	C3AR1
2.692e-03	-5.92	lipid localization	biological process	GO:0010876	374	5	18204	47	APOC2,PPARD,APOE,ABCB4,APOC1
2.700e-03	-5.91	RNase_T2_His_AS_2	interpro domains	IPR033130	1	1	18521	50	RNASET2
2.700e-03	-5.91	ApoC-1_sf	interpro domains	IPR043081	1	1	18521	50	APOC1
2.700e-03	-5.91	RNase_T2-like	interpro domains	IPR001568	1	1	18521	50	RNASET2
2.700e-03	-5.91	1Cnucl_rcpt_B	interpro domains	IPR003075	1	1	18521	50	PPARD
2.700e-03	-5.91	Collagen_XVIII_Fz	interpro domains	IPR035523	1	1	18521	50	COL18A1
2.700e-03	-5.91	DUF959_COL18_N	interpro domains	IPR010363	1	1	18521	50	COL18A1
2.700e-03	-5.91	ANR22	interpro domains	IPR042802	1	1	18521	50	ANKRD22
2.700e-03	-5.91	ALPK1	interpro domains	IPR043529	1	1	18521	50	ALPK1
2.700e-03	-5.91	GPR34_7tmA	interpro domains	IPR048057	1	1	18521	50	GPR34
2.700e-03	-5.91	ApoC-I	interpro domains	IPR006781	1	1	18521	50	APOC1
2.700e-03	-5.91	Osteopontin_CS	interpro domains	IPR019841	1	1	18521	50	SPP1
2.700e-03	-5.91	Osteopontin	interpro domains	IPR002038	1	1	18521	50	SPP1
2.700e-03	-5.91	Ribonuclease_T2_eukaryotic	interpro domains	IPR033697	1	1	18521	50	RNASET2
2.700e-03	-5.91	Adeno_A3_rcpt	interpro domains	IPR000466	1	1	18521	50	ADORA3
2.700e-03	-5.91	RGL3_RA	interpro domains	IPR030750	1	1	18521	50	RGL3
2.700e-03	-5.91	Apo-CII	interpro domains	IPR008019	1	1	18521	50	APOC2
2.700e-03	-5.91	CSF-1_receptor	interpro domains	IPR030658	1	1	18521	50	CSF1R
2.700e-03	-5.91	RNase_T2-like_sf	interpro domains	IPR036430	1	1	18521	50	RNASET2
2.700e-03	-5.91	RNase_H1_euk	interpro domains	IPR017067	1	1	18521	50	RNASEH1
2.700e-03	-5.91	RNase_T2_His_AS_1	interpro domains	IPR018188	1	1	18521	50	RNASET2
2.700e-03	-5.91	RGS10_RGS	interpro domains	IPR037879	1	1	18521	50	RGS10
2.700e-03	-5.91	ApoC-II_dom_sf	interpro domains	IPR023121	1	1	18521	50	APOC2
2.700e-03	-5.91	Anaphtx_C3AR1	interpro domains	IPR001644	1	1	18521	50	C3AR1
2.700e-03	-5.91	KLHL5_BTB/POZ	interpro domains	IPR030606	1	1	18521	50	KLHL5
2.710e-03	-5.91	mammary gland duct morphogenesis	biological process	GO:0060603	30	2	18204	47	WNT5A,CSF1R
2.710e-03	-5.91	negative regulation of sterol transport	biological process	GO:0032372	30	2	18204	47	APOC2,APOC1
2.710e-03	-5.91	negative regulation of cholesterol transport	biological process	GO:0032375	30	2	18204	47	APOC1,APOC2
2.713e-03	-5.91	Lipoprotein metabolism	REACTOME pathways	R-HSA-174824	74	3	10285	39	APOC1,APOC2,APOE
2.786e-03	-5.88	regulation of neurogenesis	biological process	GO:0050767	377	5	18204	47	BHLHE41,SPP1,CXCL12,WNT5A,TREM2
2.796e-03	-5.88	postsynapse organization	biological process	GO:0099173	109	3	18204	47	TREM2,WNT5A,APOE
2.801e-03	-5.88	regulation of secretion by cell	biological process	GO:1903530	551	6	18204	47	TREM2,MEF2C,ADORA3,CXCL12,APOE,SPP1
2.810e-03	-5.87	Osteopontin	pfam domains	PF00865	1	1	17795	50	SPP1
2.810e-03	-5.87	Ribonuclease_T2	pfam domains	PF00445	1	1	17795	50	RNASET2
2.810e-03	-5.87	Apo-CII	pfam domains	PF05355	1	1	17795	50	APOC2
2.810e-03	-5.87	RNase_H	pfam domains	PF00075	1	1	17795	50	RNASEH1
2.810e-03	-5.87	ApoC-I	pfam domains	PF04691	1	1	17795	50	APOC1
2.810e-03	-5.87	DUF959	pfam domains	PF06121	1	1	17795	50	COL18A1
2.882e-03	-5.85	OSTEO	smart domains	SM00017	1	1	9717	28	SPP1
2.892e-03	-5.85	microglial cell activation	biological process	GO:0001774	31	2	18204	47	C1QA,TREM2
2.898e-03	-5.84	cellular response to stimulus	biological process	GO:0051716	6307	26	18204	47	P2RY13,ALPK1,CD68,HAVCR2,ADORA3,MEF2C,GPR34,TREM2,CSF1R,ABCB4,FOLR2,RGS10,RGL3,C3AR1,CH25H,SIGLEC8,KCNMB1,PDGFA,WNT5A,CSF2RA,PPARD,APOE,AXL,LTC4S,CXCL12,SPP1
2.916e-03	-5.84	positive regulation of cell activation	biological process	GO:0050867	381	5	18204	47	MEF2C,AXL,TREM2,WNT5A,HAVCR2
3.036e-03	-5.80	RNASE_T2_2	prosite domains	PS00531	1	1	12186	37	RNASET2
3.036e-03	-5.80	OSTEOPONTIN	prosite domains	PS00884	1	1	12186	37	SPP1
3.036e-03	-5.80	RNASE_T2_1	prosite domains	PS00530	1	1	12186	37	RNASET2
3.041e-03	-5.80	Apolipoprotein C-I	gene3d domains	4.10.260.30	1	1	14470	44	APOC1
3.041e-03	-5.80	Ribonuclease T2-like	gene3d domains	3.90.730.10	1	1	14470	44	RNASET2
3.041e-03	-5.80	Apolipoprotein C-II	gene3d domains	1.10.1440.10	1	1	14470	44	APOC2
3.051e-03	-5.79	lipoprotein particle binding	molecular function	GO:0071813	31	2	18094	48	APOE,TREM2
3.051e-03	-5.79	protein-lipid complex binding	molecular function	GO:0071814	31	2	18094	48	TREM2,APOE
3.074e-03	-5.78	regulation of response to stress	biological process	GO:0080134	1431	10	18204	47	PPARD,HAVCR2,APOE,ALPK1,PDGFA,WNT5A,TREM2,CXCL12,SPP1,MEF2C
3.110e-03	-5.77	Pertussis	KEGG pathways	ko05133	76	3	7161	28	C1QB,C1QA,C1QC
3.110e-03	-5.77	Pertussis	KEGG pathways	hsa05133	76	3	7161	28	C1QC,C1QA,C1QB
3.174e-03	-5.75	negative regulation of small molecule metabolic process	biological process	GO:0062014	114	3	18204	47	CH25H,APOC1,APOE
3.188e-03	-5.75	immune effector process	biological process	GO:0002252	389	5	18204	47	C1QC,HAVCR2,C1QB,TREM2,C1QA
3.241e-03	-5.73	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	11	18204	47	APOE,TREM2,WNT5A,CXCL12,SPP1,APOC2,CSF1R,AXL,HAVCR2,C3AR1,MEF2C
3.255e-03	-5.73	signaling	biological process	GO:0023052	4968	22	18204	47	TREM2,RGS10,CSF1R,ALPK1,HAVCR2,P2RY13,GPR34,ADORA3,MEF2C,PPARD,APOE,PDGFA,WNT5A,CSF2RA,SPP1,CXCL12,AXL,C3AR1,RGL3,KCNMB1,C1QA,SIGLEC8
3.274e-03	-5.72	regulation of mesenchymal cell proliferation	biological process	GO:0010464	33	2	18204	47	WNT5A,PDGFA
3.278e-03	-5.72	blood microparticle	cellular component	GO:0072562	116	3	19108	49	C1QB,APOE,C1QC
3.473e-03	-5.66	negative regulation of steroid metabolic process	biological process	GO:0045939	34	2	18204	47	CH25H,APOE
3.473e-03	-5.66	leukocyte activation involved in inflammatory response	biological process	GO:0002269	34	2	18204	47	C1QA,TREM2
3.498e-03	-5.66	regulation of type II interferon production	biological process	GO:0032649	118	3	18204	47	HAVCR2,AXL,WNT5A
3.622e-03	-5.62	Pathways in cancer	KEGG pathways	hsa05200	395	6	7161	28	WNT5A,CSF1R,PPARD,PDGFA,CXCL12,CSF2RA
3.644e-03	-5.61	cell communication	biological process	GO:0007154	5010	22	18204	47	CSF1R,AXL,SPP1,CXCL12,RGS10,WNT5A,PDGFA,CSF2RA,TREM2,PPARD,APOE,ADORA3,C1QA,MEF2C,SIGLEC8,GPR34,KCNMB1,RGL3,P2RY13,C3AR1,ALPK1,HAVCR2
3.677e-03	-5.61	positive regulation of T cell migration	biological process	GO:2000406	35	2	18204	47	CXCL12,WNT5A
3.677e-03	-5.61	maternal placenta development	biological process	GO:0001893	35	2	18204	47	PPARD,SPP1
3.681e-03	-5.60	regulation of synapse organization	biological process	GO:0050807	246	4	18204	47	MEF2C,TREM2,WNT5A,APOE
3.815e-03	-5.57	regulation of developmental process	biological process	GO:0050793	2540	14	18204	47	PPARD,C1QC,WDR77,APOE,PDGFA,WNT5A,TREM2,SPP1,CXCL12,CSF1R,AXL,C3AR1,BHLHE41,MEF2C
3.857e-03	-5.56	CCL3L1 (C-C motif chemokine ligand 3 like 1)	protein interactions	6349	36	2	19454	50	COL18A1,WNT5A
3.857e-03	-5.56	SC5D (sterol-C5-desaturase)	protein interactions	6309	36	2	19454	50	C3AR1,TSPAN15
3.858e-03	-5.56	cell surface receptor signaling pathway	biological process	GO:0007166	1992	12	18204	47	CSF1R,AXL,CXCL12,TREM2,WNT5A,PDGFA,CSF2RA,MEF2C,ADORA3,GPR34,P2RY13,C3AR1
3.887e-03	-5.55	dendritic cell differentiation	biological process	GO:0097028	36	2	18204	47	AXL,TREM2
3.955e-03	-5.53	extracellular space	cellular component	GO:0005615	3443	17	19108	49	COL18A1,APOC1,C1QB,SPP1,OSBPL1A,ITM2B,C1QC,APOC2,ABCB4,WNT5A,AXL,EPB41L2,CXCL12,ACY3,RNASET2,PDGFA,APOE
3.988e-03	-5.52	positive regulation of cell migration	biological process	GO:0030335	592	6	18204	47	C3AR1,TREM2,WNT5A,PDGFA,CXCL12,CSF1R
3.997e-03	-5.52	regulation of multicellular organismal development	biological process	GO:2000026	1484	10	18204	47	AXL,MEF2C,CXCL12,SPP1,WNT5A,TREM2,PPARD,C3AR1,BHLHE41,C1QC
4.010e-03	-5.52	regulation of synapse structure or activity	biological process	GO:0050803	252	4	18204	47	APOE,MEF2C,TREM2,WNT5A
4.020e-03	-5.52	positive regulation of lipid metabolic process	biological process	GO:0045834	124	3	18204	47	APOE,APOC2,PPARD
4.071e-03	-5.50	TMEM68 (transmembrane protein 68)	protein interactions	137695	37	2	19454	50	TSPAN15,C3AR1
4.071e-03	-5.50	DGAT1 (diacylglycerol O-acyltransferase 1)	protein interactions	8694	37	2	19454	50	TSPAN15,C3AR1
4.102e-03	-5.50	regulation of macrophage cytokine production	biological process	GO:0010935	37	2	18204	47	AXL,WNT5A
4.102e-03	-5.50	astrocyte development	biological process	GO:0014002	37	2	18204	47	TREM2,C1QA
4.102e-03	-5.50	cellular response to low-density lipoprotein particle stimulus	biological process	GO:0071404	37	2	18204	47	CD68,TREM2
4.102e-03	-5.50	positive regulation of potassium ion transmembrane transport	biological process	GO:1901381	37	2	18204	47	KCNMB1,TREM2
4.102e-03	-5.50	olfactory bulb development	biological process	GO:0021772	37	2	18204	47	WNT5A,CSF1R
4.102e-03	-5.50	response to lipoprotein particle	biological process	GO:0055094	37	2	18204	47	CD68,TREM2
4.113e-03	-5.49	negative regulation of locomotion	biological process	GO:0040013	413	5	18204	47	CXCL12,APOE,MEF2C,ADORA3,WNT5A
4.290e-03	-5.45	MMP3 (matrix metallopeptidase 3)	protein interactions	4314	38	2	19454	50	APOE,SPP1
4.299e-03	-5.45	negative regulation of neuron projection development	biological process	GO:0010977	127	3	18204	47	SPP1,APOE,WNT5A
4.323e-03	-5.44	negative regulation of receptor-mediated endocytosis	biological process	GO:0048261	38	2	18204	47	APOC2,APOC1
4.362e-03	-5.43	regulation of growth	biological process	GO:0040008	603	6	18204	47	APOE,PPARD,WNT5A,SPP1,CXCL12,MEF2C
4.394e-03	-5.43	regulation of interleukin-1 production	biological process	GO:0032652	128	3	18204	47	WNT5A,TREM2,HAVCR2
4.432e-03	-5.42	regulation of secretion	biological process	GO:0051046	605	6	18204	47	TREM2,APOE,MEF2C,ADORA3,CXCL12,SPP1
4.549e-03	-5.39	blood vessel remodeling	biological process	GO:0001974	39	2	18204	47	MEF2C,AXL
4.549e-03	-5.39	olfactory lobe development	biological process	GO:0021988	39	2	18204	47	WNT5A,CSF1R
4.549e-03	-5.39	regulation of natural killer cell activation	biological process	GO:0032814	39	2	18204	47	HAVCR2,AXL
4.549e-03	-5.39	glial cell activation	biological process	GO:0061900	39	2	18204	47	C1QA,TREM2
4.549e-03	-5.39	animal organ formation	biological process	GO:0048645	39	2	18204	47	WNT5A,MEF2C
4.592e-03	-5.38	C3ANPHYLTXNR	prints domains	PR01060	1	1	5227	24	C3AR1
4.592e-03	-5.38	PROXISOMPABR	prints domains	PR01290	1	1	5227	24	PPARD
4.592e-03	-5.38	OSTEOPONTIN	prints domains	PR00216	1	1	5227	24	SPP1
4.592e-03	-5.38	ADENOSINEA3R	prints domains	PR00555	1	1	5227	24	ADORA3
4.687e-03	-5.36	response to calcium ion	biological process	GO:0051592	131	3	18204	47	KCNMB1,MEF2C,WNT5A
4.744e-03	-5.35	SYT16 (synaptotagmin 16)	protein interactions	83851	40	2	19454	50	APOC1,APOC2
4.781e-03	-5.34	cellular response to lipoprotein particle stimulus	biological process	GO:0071402	40	2	18204	47	CD68,TREM2
4.781e-03	-5.34	positive regulation of fatty acid metabolic process	biological process	GO:0045923	40	2	18204	47	PPARD,APOC2
4.788e-03	-5.34	negative regulation of neurogenesis	biological process	GO:0050768	132	3	18204	47	SPP1,TREM2,WNT5A
4.805e-03	-5.34	peptide binding	molecular function	GO:0042277	258	4	18094	48	C1QA,APOE,ITM2B,TREM2
4.848e-03	-5.33	cell-cell signaling	biological process	GO:0007267	822	7	18204	47	MEF2C,C1QA,KCNMB1,RGS10,WNT5A,PDGFA,APOE
4.876e-03	-5.32	positive regulation of defense response	biological process	GO:0031349	430	5	18204	47	WNT5A,TREM2,MEF2C,ALPK1,HAVCR2
4.951e-03	-5.31	positive regulation of cell motility	biological process	GO:2000147	619	6	18204	47	CSF1R,CXCL12,TREM2,PDGFA,WNT5A,C3AR1
4.977e-03	-5.30	Chylomicron-mediated lipid transport	REACTOME pathways	R-HSA-174800	28	2	10285	39	APOE,APOC2
4.980e-03	-5.30	TCAF2 (TRPM8 channel associated factor 2)	protein interactions	285966	41	2	19454	50	C3AR1,HAVCR2
4.986e-03	-5.30	regulation of leukocyte proliferation	biological process	GO:0070663	268	4	18204	47	CSF2RA,CSF1R,MEF2C,HAVCR2
5.018e-03	-5.29	apoptotic cell clearance	biological process	GO:0043277	41	2	18204	47	TREM2,AXL
5.051e-03	-5.29	negative regulation of cell development	biological process	GO:0010721	269	4	18204	47	WNT5A,TREM2,SPP1,C1QC
5.060e-03	-5.29	positive regulation of cell communication	biological process	GO:0010647	1792	11	18204	47	HAVCR2,ALPK1,MEF2C,TREM2,PDGFA,WNT5A,APOE,PPARD,AXL,CSF1R,SPP1
5.067e-03	-5.29	transmembrane signaling receptor activity	molecular function	GO:0004888	1251	9	18094	48	AXL,ADORA3,P2RY13,CSF2RA,CSF1R,SIGLEC8,GPR34,TREM2,C3AR1
5.103e-03	-5.28	positive regulation of signaling	biological process	GO:0023056	1794	11	18204	47	PPARD,ALPK1,APOE,HAVCR2,PDGFA,WNT5A,TREM2,SPP1,CSF1R,AXL,MEF2C
5.122e-03	-5.27	CSF1-CSF1R complex	cellular component	GO:1990682	2	1	19108	49	CSF1R
5.122e-03	-5.27	platelet-derived growth factor complex	cellular component	GO:1990265	2	1	19108	49	PDGFA
5.122e-03	-5.27	chylomicron remnant	cellular component	GO:0034360	2	1	19108	49	APOE
5.122e-03	-5.27	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	49	APOE
5.134e-03	-5.27	ZNF736 (zinc finger protein 736)	protein interactions	728927	2	1	19454	50	EPB41L2
5.134e-03	-5.27	DBX1 (developing brain homeobox 1)	protein interactions	120237	2	1	19454	50	APOC1
5.134e-03	-5.27	FAM47E (family with sequence similarity 47 member E)	protein interactions	100129583	2	1	19454	50	WDR77
5.134e-03	-5.27	VAPA (VAMP associated protein A)	protein interactions	103222768	2	1	19454	50	OSBPL1A
5.157e-03	-5.27	muscle cell fate determination	biological process	GO:0007521	2	1	18204	47	MEF2C
5.157e-03	-5.27	positive regulation of antigen processing and presentation of peptide antigen	biological process	GO:0002585	2	1	18204	47	TREM2
5.157e-03	-5.27	cervix development	biological process	GO:0060067	2	1	18204	47	WNT5A
5.157e-03	-5.27	cellular response to folic acid	biological process	GO:0071231	2	1	18204	47	FOLR2
5.157e-03	-5.27	response to ultrasound	biological process	GO:1990478	2	1	18204	47	CXCL12
5.157e-03	-5.27	negative regulation of macrophage colony-stimulating factor production	biological process	GO:1901257	2	1	18204	47	HAVCR2
5.157e-03	-5.27	positive regulation of timing of anagen	biological process	GO:0051885	2	1	18204	47	WNT5A
5.157e-03	-5.27	platelet-derived growth factor receptor-alpha signaling pathway	biological process	GO:0035790	2	1	18204	47	PDGFA
5.157e-03	-5.27	chemorepulsion of dopaminergic neuron axon	biological process	GO:0036518	2	1	18204	47	WNT5A
5.157e-03	-5.27	positive regulation of alkaline phosphatase activity	biological process	GO:0010694	2	1	18204	47	MEF2C
5.157e-03	-5.27	response to fenofibrate	biological process	GO:1901557	2	1	18204	47	ABCB4
5.157e-03	-5.27	sinoatrial valve development	biological process	GO:0003172	2	1	18204	47	MEF2C
5.157e-03	-5.27	planar cell polarity pathway involved in gastrula mediolateral intercalation	biological process	GO:0060775	2	1	18204	47	WNT5A
5.157e-03	-5.27	lateral sprouting involved in mammary gland duct morphogenesis	biological process	GO:0060599	2	1	18204	47	WNT5A
5.157e-03	-5.27	mediolateral intercalation	biological process	GO:0060031	2	1	18204	47	WNT5A
5.157e-03	-5.27	detection of peptidoglycan	biological process	GO:0032499	2	1	18204	47	TREM2
5.157e-03	-5.27	nephron tubule epithelial cell differentiation	biological process	GO:0072160	2	1	18204	47	MEF2C
5.157e-03	-5.27	embryonic lung development	biological process	GO:1990401	2	1	18204	47	PDGFA
5.157e-03	-5.27	positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	biological process	GO:0002582	2	1	18204	47	TREM2
5.157e-03	-5.27	hypophysis morphogenesis	biological process	GO:0048850	2	1	18204	47	WNT5A
5.157e-03	-5.27	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	47	APOE
5.157e-03	-5.27	positive regulation of engulfment of apoptotic cell	biological process	GO:1901076	2	1	18204	47	TREM2
5.157e-03	-5.27	response to trichostatin A	biological process	GO:0035983	2	1	18204	47	MEF2C
5.157e-03	-5.27	negative regulation of phosphatidylcholine metabolic process	biological process	GO:0150174	2	1	18204	47	APOC1
5.157e-03	-5.27	cellular response to trichostatin A	biological process	GO:0035984	2	1	18204	47	MEF2C
5.157e-03	-5.27	positive regulation of estradiol secretion	biological process	GO:2000866	2	1	18204	47	SPP1
5.157e-03	-5.27	NMDA selective glutamate receptor signaling pathway	biological process	GO:0098989	2	1	18204	47	MEF2C
5.157e-03	-5.27	negative regulation of phosphatidylinositol biosynthetic process	biological process	GO:0010512	2	1	18204	47	PDGFA
5.157e-03	-5.27	positive regulation of inward rectifier potassium channel activity	biological process	GO:1901980	2	1	18204	47	TREM2
5.157e-03	-5.27	optic cup formation involved in camera-type eye development	biological process	GO:0003408	2	1	18204	47	WNT5A
5.157e-03	-5.27	negative regulation of immunological synapse formation	biological process	GO:2000521	2	1	18204	47	HAVCR2
5.157e-03	-5.27	positive regulation of very-low-density lipoprotein particle remodeling	biological process	GO:0010902	2	1	18204	47	APOC2
5.157e-03	-5.27	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	biological process	GO:0002588	2	1	18204	47	TREM2
5.157e-03	-5.27	regulation of alkaline phosphatase activity	biological process	GO:0010692	2	1	18204	47	MEF2C
5.157e-03	-5.27	AMPA selective glutamate receptor signaling pathway	biological process	GO:0098990	2	1	18204	47	MEF2C
5.157e-03	-5.27	regulation of interleukin-3 production	biological process	GO:0032672	2	1	18204	47	HAVCR2
5.202e-03	-5.26	regulation of MAP kinase activity	biological process	GO:0043405	136	3	18204	47	APOE,PDGFA,WNT5A
5.220e-03	-5.26	COL5A1 (collagen type V alpha 1 chain)	protein interactions	1289	42	2	19454	50	PDGFA,C1QC
5.244e-03	-5.25	P2YPURNOCPTR	prints domains	PR01157	24	2	5227	24	GPR34,P2RY13
5.260e-03	-5.25	regulation of cholesterol metabolic process	biological process	GO:0090181	42	2	18204	47	CH25H,APOE
5.260e-03	-5.25	regulation of catecholamine secretion	biological process	GO:0050433	42	2	18204	47	ADORA3,CXCL12
5.260e-03	-5.25	triglyceride homeostasis	biological process	GO:0070328	42	2	18204	47	APOE,APOC2
5.260e-03	-5.25	positive regulation of lymphocyte migration	biological process	GO:2000403	42	2	18204	47	CXCL12,WNT5A
5.299e-03	-5.24	macrophage colony-stimulating factor receptor activity	molecular function	GO:0005011	2	1	18094	48	CSF1R
5.299e-03	-5.24	chemoattractant activity involved in axon guidance	molecular function	GO:1902379	2	1	18094	48	WNT5A
5.299e-03	-5.24	folic acid receptor activity	molecular function	GO:0061714	2	1	18094	48	FOLR2
5.392e-03	-5.22	RNase_H1_N	interpro domains	IPR011320	2	1	18521	50	RNASEH1
5.392e-03	-5.22	RNase_H1_N_sf	interpro domains	IPR037056	2	1	18521	50	RNASEH1
5.392e-03	-5.22	PDGF_N	interpro domains	IPR006782	2	1	18521	50	PDGFA
5.392e-03	-5.22	IL3Ra_N	interpro domains	IPR040907	2	1	18521	50	CSF2RA
5.392e-03	-5.22	RNaseH_domain	interpro domains	IPR002156	2	1	18521	50	RNASEH1
5.392e-03	-5.22	PH2_ADAP	interpro domains	IPR037851	2	1	18521	50	ADAP2
5.392e-03	-5.22	P2Y13_rcpt	interpro domains	IPR008109	2	1	18521	50	P2RY13
5.392e-03	-5.22	PH1_ADAP	interpro domains	IPR037849	2	1	18521	50	ADAP2
5.392e-03	-5.22	XV/XVIII_trimerization_dom	interpro domains	IPR045463	2	1	18521	50	COL18A1
5.392e-03	-5.22	Collagenase_NC10/endostatin	interpro domains	IPR010515	2	1	18521	50	COL18A1
5.392e-03	-5.22	Ribosomal_bL9/RNase_H1_N	interpro domains	IPR009027	2	1	18521	50	RNASEH1
5.392e-03	-5.22	Aste_AspA	interpro domains	IPR007036	2	1	18521	50	ACY3
5.392e-03	-5.22	Aspartoacylase	interpro domains	IPR016708	2	1	18521	50	ACY3
5.418e-03	-5.22	regulation of axonogenesis	biological process	GO:0050770	138	3	18204	47	WNT5A,CXCL12,SPP1
5.418e-03	-5.22	negative regulation of nervous system development	biological process	GO:0051961	138	3	18204	47	WNT5A,TREM2,SPP1
5.466e-03	-5.21	SLC22A18 (solute carrier family 22 member 18)	protein interactions	5002	43	2	19454	50	HAVCR2,C3AR1
5.466e-03	-5.21	FGF4 (fibroblast growth factor 4)	protein interactions	2249	43	2	19454	50	COL18A1,HS3ST1
5.508e-03	-5.20	acylglycerol homeostasis	biological process	GO:0055090	43	2	18204	47	APOC2,APOE
5.508e-03	-5.20	regulation of bone resorption	biological process	GO:0045124	43	2	18204	47	CSF1R,SPP1
5.514e-03	-5.20	positive regulation of locomotion	biological process	GO:0040017	633	6	18204	47	CSF1R,CXCL12,TREM2,PDGFA,WNT5A,C3AR1
5.527e-03	-5.20	cellular response to hypoxia	biological process	GO:0071456	139	3	18204	47	TREM2,KCNMB1,PPARD
5.557e-03	-5.19	response to organic cyclic compound	biological process	GO:0014070	843	7	18204	47	PPARD,P2RY13,KCNMB1,SPP1,FOLR2,MEF2C,ABCB4
5.557e-03	-5.19	regulation of defense response	biological process	GO:0031347	843	7	18204	47	MEF2C,WNT5A,TREM2,PPARD,APOE,ALPK1,HAVCR2
5.585e-03	-5.19	TNFSF8 (TNF superfamily member 8)	protein interactions	944	140	3	19454	50	ITM2B,HS3ST1,DCBLD1
5.612e-03	-5.18	Collagen_trimer	pfam domains	PF20010	2	1	17795	50	COL18A1
5.612e-03	-5.18	AstE_AspA	pfam domains	PF04952	2	1	17795	50	ACY3
5.612e-03	-5.18	Cauli_VI	pfam domains	PF01693	2	1	17795	50	RNASEH1
5.612e-03	-5.18	IL3Ra_N	pfam domains	PF18611	2	1	17795	50	CSF2RA
5.612e-03	-5.18	Endostatin	pfam domains	PF06482	2	1	17795	50	COL18A1
5.612e-03	-5.18	PDGF_N	pfam domains	PF04692	2	1	17795	50	PDGFA
5.717e-03	-5.16	LPCAT4 (lysophosphatidylcholine acyltransferase 4)	protein interactions	254531	44	2	19454	50	TSPAN15,HAVCR2
5.717e-03	-5.16	COL4A1 (collagen type IV alpha 1 chain)	protein interactions	1282	44	2	19454	50	COL18A1,PDGFA
5.760e-03	-5.16	mammary gland morphogenesis	biological process	GO:0060443	44	2	18204	47	CSF1R,WNT5A
5.760e-03	-5.16	negative regulation of type II interferon production	biological process	GO:0032689	44	2	18204	47	HAVCR2,AXL
5.842e-03	-5.14	regulation of innate immune response	biological process	GO:0045088	449	5	18204	47	WNT5A,TREM2,ALPK1,APOE,HAVCR2
5.864e-03	-5.14	neuron migration	biological process	GO:0001764	142	3	18204	47	MEF2C,AXL,CXCL12
5.915e-03	-5.13	human chr1p13.2	chromosome location	human chr1p13.2	60	2	26134	50	ADORA3,WDR77
5.976e-03	-5.12	regulation of intracellular signal transduction	biological process	GO:1902531	1832	11	18204	47	PPARD,APOE,PDGFA,WNT5A,TREM2,CXCL12,AXL,CSF1R,HAVCR2,ALPK1,MEF2C
5.979e-03	-5.12	regulation of cellular ketone metabolic process	biological process	GO:0010565	143	3	18204	47	APOC2,PPARD,APOC1
6.018e-03	-5.11	positive regulation of potassium ion transport	biological process	GO:0043268	45	2	18204	47	KCNMB1,TREM2
6.018e-03	-5.11	negative regulation of blood coagulation	biological process	GO:0030195	45	2	18204	47	APOE,PDGFA
6.018e-03	-5.11	embryo implantation	biological process	GO:0007566	45	2	18204	47	PPARD,SPP1
6.033e-03	-5.11	regulation of transferase activity	biological process	GO:0051338	645	6	18204	47	APOE,WNT5A,PDGFA,TREM2,CSF1R,AXL
6.064e-03	-5.11	RNASE_H_1	prosite domains	PS50879	2	1	12186	37	RNASEH1
6.073e-03	-5.10	-	gene3d domains	2.20.25.160	2	1	14470	44	ACY3
6.073e-03	-5.10	-	gene3d domains	3.40.1620.70	2	1	14470	44	COL18A1
6.073e-03	-5.10	Ribonuclease H1, N-terminal domain	gene3d domains	3.40.970.10	2	1	14470	44	RNASEH1
6.121e-03	-5.10	P4HA1 (prolyl 4-hydroxylase subunit alpha 1)	protein interactions	5033	285	4	19454	50	COL18A1,APOE,AXL,WDR77
6.174e-03	-5.09	regulation of cellular catabolic process	biological process	GO:0031329	455	5	18204	47	TSPAN15,TREM2,APOC1,APOC2,APOE
6.230e-03	-5.08	regulation of nervous system development	biological process	GO:0051960	456	5	18204	47	TREM2,WNT5A,BHLHE41,SPP1,CXCL12
6.230e-03	-5.08	pattern specification process	biological process	GO:0007389	456	5	18204	47	WNT5A,MEF2C,C1QA,WDR77,BHLHE41
6.234e-03	-5.08	TM9SF1 (transmembrane 9 superfamily member 1)	protein interactions	10548	46	2	19454	50	RNASEH1,TSPAN15
6.282e-03	-5.07	regulation of triglyceride metabolic process	biological process	GO:0090207	46	2	18204	47	APOC2,APOE
6.282e-03	-5.07	negative regulation of hemostasis	biological process	GO:1900047	46	2	18204	47	APOE,PDGFA
6.282e-03	-5.07	negative chemotaxis	biological process	GO:0050919	46	2	18204	47	WNT5A,PDGFA
6.332e-03	-5.06	cellular response to decreased oxygen levels	biological process	GO:0036294	146	3	18204	47	TREM2,PPARD,KCNMB1
6.500e-03	-5.04	PTGER4 (prostaglandin E receptor 4)	protein interactions	5734	47	2	19454	50	SPP1,ACY3
6.502e-03	-5.04	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	3	10285	39	DHRS9,APOE,APOC2
6.550e-03	-5.03	genitalia development	biological process	GO:0048806	47	2	18204	47	AXL,WNT5A
6.550e-03	-5.03	negative regulation of lipid transport	biological process	GO:0032369	47	2	18204	47	APOC1,APOC2
6.587e-03	-5.02	positive regulation of signal transduction	biological process	GO:0009967	1593	10	18204	47	CSF1R,MEF2C,AXL,APOE,ALPK1,HAVCR2,PPARD,TREM2,WNT5A,PDGFA
6.730e-03	-5.00	response to hypoxia	biological process	GO:0001666	292	4	18204	47	KCNMB1,CXCL12,PPARD,TREM2
6.772e-03	-4.99	NACC2 (NACC family member 2)	protein interactions	138151	48	2	19454	50	OSBPL1A,PPARD
6.772e-03	-4.99	NOCT (nocturnin)	protein interactions	25819	48	2	19454	50	C1QB,HAVCR2
6.810e-03	-4.99	negative regulation of defense response	biological process	GO:0031348	293	4	18204	47	TREM2,PPARD,APOE,HAVCR2
6.824e-03	-4.99	negative regulation of axonogenesis	biological process	GO:0050771	48	2	18204	47	SPP1,WNT5A
7.098e-03	-4.95	Chagas disease (American trypanosomiasis)	KEGG pathways	ko05142	102	3	7161	28	C1QA,C1QC,C1QB
7.098e-03	-4.95	Chagas disease (American trypanosomiasis)	KEGG pathways	hsa05142	102	3	7161	28	C1QB,C1QA,C1QC
7.103e-03	-4.95	negative regulation of coagulation	biological process	GO:0050819	49	2	18204	47	PDGFA,APOE
7.103e-03	-4.95	regulation of T cell migration	biological process	GO:2000404	49	2	18204	47	WNT5A,CXCL12
7.138e-03	-4.94	carboxylic acid transport	biological process	GO:0046942	297	4	18204	47	ABCB4,FOLR2,APOE,PPARD
7.203e-03	-4.93	leukocyte proliferation	biological process	GO:0070661	153	3	18204	47	CSF1R,TREM2,MEF2C
7.222e-03	-4.93	organic acid transport	biological process	GO:0015849	298	4	18204	47	PPARD,FOLR2,APOE,ABCB4
7.272e-03	-4.92	Ig_3	pfam domains	PF13927	141	3	17795	50	CSF1R,AXL,SIGLEC8
7.281e-03	-4.92	Synthesis of bile acids and bile salts	REACTOME pathways	R-HSA-192105	34	2	10285	39	OSBPL1A,CH25H
7.304e-03	-4.92	Immune System	REACTOME pathways	R-HSA-168256	2101	15	10285	39	SIGLEC8,CSF1R,C1QA,CD68,C3AR1,PDGFA,MEF2C,C1QB,CSF2RA,RNASET2,OSBPL1A,KLHL5,TREM2,C1QC,HAVCR2
7.330e-03	-4.92	ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13)	protein interactions	54503	50	2	19454	50	C3AR1,TSPAN15
7.333e-03	-4.92	monocarboxylic acid transport	biological process	GO:0015718	154	3	18204	47	PPARD,APOE,ABCB4
7.386e-03	-4.91	modulation by host of viral process	biological process	GO:0044788	50	2	18204	47	APOE,CSF1R
7.386e-03	-4.91	vasodilation	biological process	GO:0042311	50	2	18204	47	APOE,KCNMB1
7.386e-03	-4.91	neuroinflammatory response	biological process	GO:0150076	50	2	18204	47	C1QA,TREM2
7.464e-03	-4.90	myeloid leukocyte activation	biological process	GO:0002274	155	3	18204	47	TREM2,C1QA,HAVCR2
7.472e-03	-4.90	primary lysosome	cellular component	GO:0005766	156	3	19108	49	RNASET2,C3AR1,CD68
7.472e-03	-4.90	azurophil granule	cellular component	GO:0042582	156	3	19108	49	C3AR1,RNASET2,CD68
7.477e-03	-4.90	lipid catabolic process	biological process	GO:0016042	301	4	18204	47	APOE,SPP1,PPARD,APOC2
7.485e-03	-4.89	fatty acid binding	molecular function	GO:0005504	49	2	18094	48	APOC1,PPARD
7.563e-03	-4.88	immune response-activating signaling pathway	biological process	GO:0002757	302	4	18204	47	C3AR1,HAVCR2,ALPK1,MEF2C
7.587e-03	-4.88	extracellular exosome	cellular component	GO:0070062	2175	12	19108	49	ITM2B,SPP1,OSBPL1A,COL18A1,ABCB4,WNT5A,APOE,EPB41L2,AXL,ACY3,CXCL12,RNASET2
7.602e-03	-4.88	regulation of anatomical structure morphogenesis	biological process	GO:0022603	894	7	18204	47	C3AR1,WNT5A,PDGFA,SPP1,CXCL12,MEF2C,CSF1R
7.675e-03	-4.87	regulation of granulocyte chemotaxis	biological process	GO:0071622	51	2	18204	47	C3AR1,CSF1R
7.675e-03	-4.87	regulation of bone remodeling	biological process	GO:0046850	51	2	18204	47	SPP1,CSF1R
7.691e-03	-4.87	ZNF534 (zinc finger protein 534)	protein interactions	147658	3	1	19454	50	C1QC
7.691e-03	-4.87	Pebp1 (phosphatidylethanolamine binding protein 1)	protein interactions	23980	3	1	19454	50	PPARD
7.691e-03	-4.87	NRN1L (neuritin 1 like)	protein interactions	123904	3	1	19454	50	TREM2
7.721e-03	-4.86	regulation of cellular component organization	biological process	GO:0051128	2455	13	18204	47	WNT5A,PDGFA,TREM2,APOE,AXL,CSF1R,ABCB4,APOC2,CXCL12,SPP1,APOC1,CH25H,MEF2C
7.726e-03	-4.86	positive regulation of phospholipid catabolic process	biological process	GO:0060697	3	1	18204	47	APOC2
7.726e-03	-4.86	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	47	APOE
7.726e-03	-4.86	regulation of tolerance induction dependent upon immune response	biological process	GO:0002652	3	1	18204	47	HAVCR2
7.726e-03	-4.86	regulation of cell proliferation in midbrain	biological process	GO:1904933	3	1	18204	47	WNT5A
7.726e-03	-4.86	cardiac right atrium morphogenesis	biological process	GO:0003213	3	1	18204	47	WNT5A
7.726e-03	-4.86	mesodermal to mesenchymal transition involved in gastrulation	biological process	GO:0060809	3	1	18204	47	WNT5A
7.726e-03	-4.86	regulation of phosphatidylcholine catabolic process	biological process	GO:0010899	3	1	18204	47	APOC1
7.726e-03	-4.86	positive regulation of chemokine-mediated signaling pathway	biological process	GO:0070101	3	1	18204	47	TREM2
7.726e-03	-4.86	regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	biological process	GO:1900238	3	1	18204	47	PDGFA
7.726e-03	-4.86	complement component C5a signaling pathway	biological process	GO:0038178	3	1	18204	47	C3AR1
7.726e-03	-4.86	positive regulation of low-density lipoprotein particle clearance	biological process	GO:1905581	3	1	18204	47	TREM2
7.726e-03	-4.86	positive regulation of metanephric mesenchymal cell migration	biological process	GO:2000591	3	1	18204	47	PDGFA
7.726e-03	-4.86	vertebrate eye-specific patterning	biological process	GO:0150064	3	1	18204	47	C1QA
7.726e-03	-4.86	diencephalon morphogenesis	biological process	GO:0048852	3	1	18204	47	WNT5A
7.726e-03	-4.86	chemoattraction of axon	biological process	GO:0061642	3	1	18204	47	WNT5A
7.726e-03	-4.86	regulation of estradiol secretion	biological process	GO:2000864	3	1	18204	47	SPP1
7.726e-03	-4.86	negative regulation of natural killer cell mediated immune response to tumor cell	biological process	GO:0002856	3	1	18204	47	HAVCR2
7.726e-03	-4.86	regulation of engulfment of apoptotic cell	biological process	GO:1901074	3	1	18204	47	TREM2
7.726e-03	-4.86	positive regulation of macrophage apoptotic process	biological process	GO:2000111	3	1	18204	47	MEF2C
7.726e-03	-4.86	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	biological process	GO:2001189	3	1	18204	47	HAVCR2
7.726e-03	-4.86	regulation of synaptic activity	biological process	GO:0060025	3	1	18204	47	MEF2C
7.726e-03	-4.86	outer hair cell apoptotic process	biological process	GO:1905584	3	1	18204	47	USP53
7.726e-03	-4.86	negative regulation of autophagic cell death	biological process	GO:1904093	3	1	18204	47	TREM2
7.726e-03	-4.86	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	biological process	GO:0035793	3	1	18204	47	PDGFA
7.726e-03	-4.86	negative regulation of myeloid dendritic cell activation	biological process	GO:0030886	3	1	18204	47	HAVCR2
7.726e-03	-4.86	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	biological process	GO:0002859	3	1	18204	47	HAVCR2
7.726e-03	-4.86	negative regulation of macrophage colony-stimulating factor signaling pathway	biological process	GO:1902227	3	1	18204	47	TREM2
7.726e-03	-4.86	ceramide translocation	biological process	GO:0099040	3	1	18204	47	ABCB4
7.726e-03	-4.86	chylomicron remodeling	biological process	GO:0034371	3	1	18204	47	APOC2
7.726e-03	-4.86	regulation of CAMKK-AMPK signaling cascade	biological process	GO:1905289	3	1	18204	47	TREM2
7.726e-03	-4.86	natural killer cell tolerance induction	biological process	GO:0002519	3	1	18204	47	HAVCR2
7.726e-03	-4.86	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	biological process	GO:0060528	3	1	18204	47	WDR77
7.736e-03	-4.86	7tm_1	pfam domains	PF00001	279	4	17795	50	GPR34,C3AR1,P2RY13,ADORA3
7.792e-03	-4.85	APOE (apolipoprotein E)	protein interactions	348	158	3	19454	50	APOE,TREM2,APOC2
7.805e-03	-4.85	response to bacterium	biological process	GO:0009617	681	6	18204	47	WNT5A,TREM2,CD68,HAVCR2,AXL,MEF2C
7.832e-03	-4.85	signal transduction	biological process	GO:0007165	4637	20	18204	47	PDGFA,WNT5A,CSF2RA,TREM2,PPARD,APOE,CSF1R,AXL,CXCL12,SPP1,RGS10,P2RY13,RGL3,C3AR1,ALPK1,HAVCR2,ADORA3,MEF2C,SIGLEC8,GPR34
7.914e-03	-4.84	response to decreased oxygen levels	biological process	GO:0036293	306	4	18204	47	TREM2,KCNMB1,CXCL12,PPARD
7.928e-03	-4.84	TYRO3 (TYRO3 protein tyrosine kinase)	protein interactions	7301	159	3	19454	50	AXL,APOE,ITM2B
7.928e-03	-4.84	EPB41L1 (erythrocyte membrane protein band 4.1 like 1)	protein interactions	2036	159	3	19454	50	AXL,WDR77,EPB41L2
7.938e-03	-4.84	complement component C5a receptor activity	molecular function	GO:0004878	3	1	18094	48	C3AR1
7.938e-03	-4.84	C-4 methylsterol oxidase activity	molecular function	GO:0000254	3	1	18094	48	CH25H
7.938e-03	-4.84	ceramide floppase activity	molecular function	GO:0099038	3	1	18094	48	ABCB4
7.969e-03	-4.83	negative regulation of cellular process	biological process	GO:0048523	5320	22	18204	47	MEF2C,ADORA3,HAVCR2,RGS10,APOC2,CSF1R,TREM2,CH25H,BHLHE41,APOC1,COL18A1,SPP1,CXCL12,AXL,TSPAN15,C1QC,APOE,WDR77,PPARD,ITM2B,WNT5A,PDGFA
8.023e-03	-4.83	tube morphogenesis	biological process	GO:0035239	685	6	18204	47	CSF1R,MEF2C,APOE,PDGFA,WNT5A,COL18A1
8.034e-03	-4.82	response to nutrient levels	biological process	GO:0031667	485	5	18204	47	SPP1,APOE,CD68,FOLR2,PPARD
8.078e-03	-4.82	LAMP_CS	interpro domains	IPR018134	3	1	18521	50	CD68
8.078e-03	-4.82	RGS10/12/14-like	interpro domains	IPR046995	3	1	18521	50	RGS10
8.078e-03	-4.82	FLAP/GST2/LTC4S_CS	interpro domains	IPR018295	3	1	18521	50	LTC4S
8.078e-03	-4.82	1Cnucl_rcpt	interpro domains	IPR003074	3	1	18521	50	PPARD
8.078e-03	-4.82	ITM2	interpro domains	IPR040145	3	1	18521	50	ITM2B
8.078e-03	-4.82	5_LipOase_AP	interpro domains	IPR001446	3	1	18521	50	LTC4S
8.078e-03	-4.82	Anphylx_rcpt_C3a/C5a1-2	interpro domains	IPR002234	3	1	18521	50	C3AR1
8.206e-03	-4.80	NFU1 (NFU1 iron-sulfur cluster scaffold)	protein interactions	27247	53	2	19454	50	APOC1,APOC2
8.268e-03	-4.80	regulation of platelet activation	biological process	GO:0010543	53	2	18204	47	APOE,PDGFA
8.281e-03	-4.79	cellular response to oxygen levels	biological process	GO:0071453	161	3	18204	47	PPARD,KCNMB1,TREM2
8.295e-03	-4.79	late endosome	cellular component	GO:0005770	312	4	19108	49	TSPAN15,APOE,OSBPL1A,CD68
8.572e-03	-4.76	regulation of morphogenesis of a branching structure	biological process	GO:0060688	54	2	18204	47	WNT5A,PDGFA
8.572e-03	-4.76	regulation of fatty acid biosynthetic process	biological process	GO:0042304	54	2	18204	47	APOC1,APOC2
8.572e-03	-4.76	regulation of cholesterol efflux	biological process	GO:0010874	54	2	18204	47	APOE,TREM2
8.572e-03	-4.76	regulation of lipid storage	biological process	GO:0010883	54	2	18204	47	TREM2,PPARD
8.572e-03	-4.76	positive regulation of ossification	biological process	GO:0045778	54	2	18204	47	MEF2C,WNT5A
8.772e-03	-4.74	V-set	pfam domains	PF07686	151	3	17795	50	TREM2,SIGLEC8,HAVCR2
8.814e-03	-4.73	ARV1 (ARV1 homolog, fatty acid homeostasis modulator)	protein interactions	64801	55	2	19454	50	TSPAN15,C3AR1
8.854e-03	-4.73	monocarboxylic acid biosynthetic process	biological process	GO:0072330	165	3	18204	47	LTC4S,OSBPL1A,DHRS9
8.881e-03	-4.72	positive regulation of fibroblast proliferation	biological process	GO:0048146	55	2	18204	47	PDGFA,WNT5A
8.881e-03	-4.72	response to axon injury	biological process	GO:0048678	55	2	18204	47	TREM2,AXL
8.890e-03	-4.72	cell migration	biological process	GO:0016477	921	7	18204	47	MEF2C,AXL,CH25H,FOLR2,CXCL12,WNT5A,PPARD
8.950e-03	-4.72	regulation of anatomical structure size	biological process	GO:0090066	498	5	18204	47	WNT5A,APOE,CXCL12,SPP1,KCNMB1
9.001e-03	-4.71	lymphocyte mediated immunity	biological process	GO:0002449	166	3	18204	47	C1QA,C1QC,C1QB
9.001e-03	-4.71	organic hydroxy compound transport	biological process	GO:0015850	166	3	18204	47	APOC2,APOE,APOC1
9.082e-03	-4.70	LAMP_2	prosite domains	PS00311	3	1	12186	37	CD68
9.082e-03	-4.70	FLAP_GST2_LTC4S	prosite domains	PS01297	3	1	12186	37	LTC4S
9.097e-03	-4.70	positive regulation of cytokine production	biological process	GO:0001819	500	5	18204	47	HAVCR2,C3AR1,CSF1R,TREM2,WNT5A
9.125e-03	-4.70	LRFN3 (leucine rich repeat and fibronectin type III domain containing 3)	protein interactions	79414	56	2	19454	50	ITM2B,C1QB
9.163e-03	-4.69	ANPHYLATOXNR	prints domains	PR01104	2	1	5227	24	C3AR1
9.163e-03	-4.69	BKCHANNELB	prints domains	PR01450	2	1	5227	24	KCNMB1
9.163e-03	-4.69	P2Y13PRNCPTR	prints domains	PR01735	2	1	5227	24	P2RY13
9.195e-03	-4.69	negative regulation of leukocyte apoptotic process	biological process	GO:2000107	56	2	18204	47	AXL,CXCL12
9.288e-03	-4.68	Lipid digestion, mobilization, and transport	REACTOME pathways	R-HSA-73923	115	3	10285	39	APOC1,APOC2,APOE
9.299e-03	-4.68	positive regulation of developmental growth	biological process	GO:0048639	168	3	18204	47	MEF2C,PPARD,CXCL12
9.328e-03	-4.67	wound healing	biological process	GO:0042060	321	4	18204	47	PPARD,WNT5A,PDGFA,AXL
9.378e-03	-4.67	negative regulation of biological process	biological process	GO:0048519	5737	23	18204	47	CH25H,COL18A1,APOC1,BHLHE41,TSPAN15,AXL,SPP1,CXCL12,PDGFA,WNT5A,ITM2B,PPARD,APOE,WDR77,C1QC,ADORA3,MEF2C,CD68,HAVCR2,CSF1R,APOC2,RGS10,TREM2
9.472e-03	-4.66	response to inorganic substance	biological process	GO:0010035	505	5	18204	47	KCNMB1,MEF2C,AXL,COL18A1,WNT5A
9.514e-03	-4.66	osteoclast differentiation	biological process	GO:0030316	57	2	18204	47	TREM2,CSF1R
9.541e-03	-4.65	Ig-like_dom_sf	interpro domains	IPR036179	483	5	18521	50	AXL,CSF1R,SIGLEC8,HAVCR2,TREM2
9.757e-03	-4.63	female pregnancy	biological process	GO:0007565	171	3	18204	47	PPARD,SPP1,HAVCR2
9.763e-03	-4.63	MFSD8 (major facilitator superfamily domain containing 8)	protein interactions	256471	58	2	19454	50	C3AR1,TSPAN15
9.763e-03	-4.63	FZD2 (frizzled class receptor 2)	protein interactions	2535	58	2	19454	50	WNT5A,TSPAN15
9.791e-03	-4.63	Nuclear Receptors in Lipid Metabolism and Toxicity	WikiPathways	WP299	35	2	5310	23	ABCB4,PPARD
9.838e-03	-4.62	mammary gland epithelium development	biological process	GO:0061180	58	2	18204	47	WNT5A,CSF1R
9.864e-03	-4.62	negative regulation of cell differentiation	biological process	GO:0045596	716	6	18204	47	WNT5A,TREM2,PPARD,C1QC,BHLHE41,SPP1
9.878e-03	-4.62	G protein-coupled receptor signaling pathway	biological process	GO:0007186	1178	8	18204	47	TREM2,P2RY13,C3AR1,APOE,ADORA3,GPR34,RGS10,CXCL12
9.999e-03	-4.61	cell adhesion	biological process	GO:0007155	942	7	18204	47	COL18A1,PPARD,SIGLEC8,AXL,CXCL12,SPP1,FOLR2
1.003e-02	-4.60	Metabolism of lipids and lipoproteins	REACTOME pathways	R-HSA-556833	813	8	10285	39	ABCB4,APOE,PPARD,OSBPL1A,LTC4S,CH25H,APOC2,APOC1
1.004e-02	-4.60	azurophil granule membrane	cellular component	GO:0035577	59	2	19108	49	CD68,C3AR1
1.009e-02	-4.60	CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4)	protein interactions	26504	59	2	19454	50	WNT5A,TSPAN15
1.009e-02	-4.60	HRG (histidine rich glycoprotein)	protein interactions	3273	59	2	19454	50	C1QB,C1QA
1.017e-02	-4.59	regulation of dendritic spine development	biological process	GO:0060998	59	2	18204	47	MEF2C,APOE
1.022e-02	-4.58	granulocyte macrophage colony-stimulating factor receptor complex	cellular component	GO:0030526	4	1	19108	49	CSF2RA
1.024e-02	-4.58	VGLL2 (vestigial like family member 2)	protein interactions	245806	4	1	19454	50	MEF2C
1.024e-02	-4.58	CREG2 (cellular repressor of E1A stimulated genes 2)	protein interactions	200407	4	1	19454	50	USP53
1.024e-02	-4.58	Nrip1 (nuclear receptor interacting protein 1)	protein interactions	268903	4	1	19454	50	PPARD
1.024e-02	-4.58	CLCA1 (chloride channel accessory 1)	protein interactions	1179	4	1	19454	50	KCNMB1
1.024e-02	-4.58	WNT5B (Wnt family member 5B)	protein interactions	81029	4	1	19454	50	WNT5A
1.029e-02	-4.58	regulation of metanephric mesenchymal cell migration	biological process	GO:2000589	4	1	18204	47	PDGFA
1.029e-02	-4.58	respiratory burst after phagocytosis	biological process	GO:0045728	4	1	18204	47	TREM2
1.029e-02	-4.58	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	47	APOE
1.029e-02	-4.58	regulation of branching involved in mammary gland duct morphogenesis	biological process	GO:0060762	4	1	18204	47	WNT5A
1.029e-02	-4.58	positive regulation of fat cell proliferation	biological process	GO:0070346	4	1	18204	47	PPARD
1.029e-02	-4.58	regulation of antigen processing and presentation of peptide antigen via MHC class II	biological process	GO:0002586	4	1	18204	47	TREM2
1.029e-02	-4.58	9-cis-retinoic acid biosynthetic process	biological process	GO:0042904	4	1	18204	47	DHRS9
1.029e-02	-4.58	macrophage colony-stimulating factor signaling pathway	biological process	GO:0038145	4	1	18204	47	CSF1R
1.029e-02	-4.58	epithelial cell proliferation involved in mammary gland duct elongation	biological process	GO:0060750	4	1	18204	47	WNT5A
1.029e-02	-4.58	epithelial cell proliferation involved in renal tubule morphogenesis	biological process	GO:2001013	4	1	18204	47	MEF2C
1.029e-02	-4.58	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	47	APOE
1.029e-02	-4.58	regulation of autophagic cell death	biological process	GO:1904092	4	1	18204	47	TREM2
1.029e-02	-4.58	positive regulation of thymocyte apoptotic process	biological process	GO:0070245	4	1	18204	47	WNT5A
1.029e-02	-4.58	regulation of macrophage colony-stimulating factor signaling pathway	biological process	GO:1902226	4	1	18204	47	TREM2
1.029e-02	-4.58	urinary bladder development	biological process	GO:0060157	4	1	18204	47	WNT5A
1.029e-02	-4.58	negative regulation of prostatic bud formation	biological process	GO:0060686	4	1	18204	47	WNT5A
1.029e-02	-4.58	response to caloric restriction	biological process	GO:0061771	4	1	18204	47	APOE
1.029e-02	-4.58	regulation of immunological synapse formation	biological process	GO:2000520	4	1	18204	47	HAVCR2
1.029e-02	-4.58	negative regulation of dendritic cell antigen processing and presentation	biological process	GO:0002605	4	1	18204	47	CD68
1.029e-02	-4.58	negative regulation of leukocyte tethering or rolling	biological process	GO:1903237	4	1	18204	47	CXCL12
1.029e-02	-4.58	DNA replication, removal of RNA primer	biological process	GO:0043137	4	1	18204	47	RNASEH1
1.029e-02	-4.58	9-cis-retinoic acid metabolic process	biological process	GO:0042905	4	1	18204	47	DHRS9
1.029e-02	-4.58	Wnt signaling pathway, calcium modulating pathway	biological process	GO:0007223	4	1	18204	47	WNT5A
1.029e-02	-4.58	granulocyte-macrophage colony-stimulating factor signaling pathway	biological process	GO:0038157	4	1	18204	47	CSF2RA
1.029e-02	-4.58	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	47	APOE
1.029e-02	-4.58	GPC1 (glypican 1)	protein interactions	2817	175	3	19454	50	PDGFA,WDR77,COL18A1
1.036e-02	-4.57	response to oxygen levels	biological process	GO:0070482	331	4	18204	47	TREM2,KCNMB1,CXCL12,PPARD
1.039e-02	-4.57	regulation of interleukin-6 production	biological process	GO:0032675	175	3	18204	47	WNT5A,TREM2,HAVCR2
1.042e-02	-4.56	COX1 (cytochrome c oxidase subunit I)	protein interactions	4512	60	2	19454	50	KCNMB1,TSPAN15
1.044e-02	-4.56	endomembrane system	cellular component	GO:0012505	4764	20	19108	49	WNT5A,DHRS9,CH25H,TSPAN15,RNASET2,C3AR1,LTC4S,APOE,PDGFA,WDR77,CD68,COL18A1,HAVCR2,APOC1,HS3ST1,ITM2B,OSBPL1A,SPP1,P2RY13,APOC2
1.045e-02	-4.56	cell activation	biological process	GO:0001775	725	6	18204	47	C1QA,MEF2C,AXL,PDGFA,TREM2,HAVCR2
1.052e-02	-4.55	cell population proliferation	biological process	GO:0008283	726	6	18204	47	PPARD,WDR77,WNT5A,MEF2C,TREM2,CSF1R
1.054e-02	-4.55	S (surface glycoprotein)	protein interactions	43740568	728	6	19454	50	USP53,C1QB,AXL,C1QA,APOE,C1QC
1.057e-02	-4.55	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	48	APOE
1.057e-02	-4.55	sphingolipid floppase activity	molecular function	GO:0046623	4	1	18094	48	ABCB4
1.057e-02	-4.55	very-low-density lipoprotein particle binding	molecular function	GO:0034189	4	1	18094	48	TREM2
1.057e-02	-4.55	lipoprotein lipase activator activity	molecular function	GO:0060230	4	1	18094	48	APOC2
1.069e-02	-4.54	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	39	16828	50	HAVCR2,FILIP1L,SPP1,C3AR1,KLHL5,DCBLD1,EPB41L2,ABCB4,C1QA,ADORA3,ANKRD22,KCNMB1,MEF2C,PPARD,COL18A1,WNT5A,APOC1,GPR34,RNASEH1,C1QB,SIGLEC8,APOE,RGL3,LTC4S,WDR77,DHRS9,TREM2,HS3ST1,OSBPL1A,AXL,ALPK1,ITM2B,ADAP2,CSF1R,C1QC,CSF2RA,FOLR2,CH25H,P2RY13
1.069e-02	-4.54	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	39	16828	50	C1QA,ABCB4,EPB41L2,KLHL5,DCBLD1,C3AR1,FILIP1L,HAVCR2,SPP1,GPR34,APOC1,RNASEH1,C1QB,WNT5A,COL18A1,MEF2C,PPARD,KCNMB1,ADORA3,ANKRD22,OSBPL1A,TREM2,HS3ST1,DHRS9,WDR77,LTC4S,APOE,RGL3,SIGLEC8,CH25H,P2RY13,FOLR2,C1QC,CSF2RA,CSF1R,ADAP2,ITM2B,AXL,ALPK1
1.073e-02	-4.53	regulation of response to stimulus	biological process	GO:0048583	4104	18	18204	47	SPP1,CXCL12,RGS10,CSF1R,AXL,TSPAN15,C1QC,APOE,PPARD,TREM2,PDGFA,WNT5A,C1QB,MEF2C,C1QA,ALPK1,HAVCR2,C3AR1
1.076e-02	-4.53	Cortactin-binding_p2_N	interpro domains	IPR019131	4	1	18521	50	FILIP1L
1.076e-02	-4.53	MADS_MEF2-like	interpro domains	IPR033896	4	1	18521	50	MEF2C
1.076e-02	-4.53	ApoA_E	interpro domains	IPR000074	4	1	18521	50	APOE
1.076e-02	-4.53	K_chnl_Ca-activ_BK_bsu	interpro domains	IPR003930	4	1	18521	50	KCNMB1
1.076e-02	-4.53	SAB_dom	interpro domains	IPR007477	4	1	18521	50	EPB41L2
1.076e-02	-4.53	Band_4	interpro domains	IPR008379	4	1	18521	50	EPB41L2
1.076e-02	-4.53	Adenosn_rcpt	interpro domains	IPR001634	4	1	18521	50	ADORA3
1.076e-02	-4.53	HJURP_C	interpro domains	IPR022102	4	1	18521	50	MEF2C
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	WDR77,SPP1
1.084e-02	-4.52	cellular component maintenance	biological process	GO:0043954	61	2	18204	47	CSF1R,TREM2
1.085e-02	-4.52	extracellular vesicle	cellular component	GO:1903561	2278	12	19108	49	COL18A1,OSBPL1A,SPP1,ITM2B,ABCB4,WNT5A,RNASET2,AXL,ACY3,EPB41L2,CXCL12,APOE
1.089e-02	-4.52	extracellular organelle	cellular component	GO:0043230	2279	12	19108	49	APOE,EPB41L2,AXL,CXCL12,ACY3,RNASET2,WNT5A,ABCB4,SPP1,OSBPL1A,ITM2B,COL18A1
1.089e-02	-4.52	extracellular membrane-bounded organelle	cellular component	GO:0065010	2279	12	19108	49	SPP1,ITM2B,OSBPL1A,COL18A1,ABCB4,WNT5A,APOE,RNASET2,AXL,ACY3,CXCL12,EPB41L2
1.094e-02	-4.52	SCCPDH (saccharopine dehydrogenase (putative))	protein interactions	51097	179	3	19454	50	C3AR1,USP53,APOE
1.104e-02	-4.51	regulation of response to wounding	biological process	GO:1903034	179	3	18204	47	APOE,SPP1,PDGFA
1.106e-02	-4.50	cellular response to cytokine stimulus	biological process	GO:0071345	734	6	18204	47	WNT5A,CSF2RA,TREM2,CSF1R,AXL,CXCL12
1.110e-02	-4.50	IL1R2 (interleukin 1 receptor type 2)	protein interactions	7850	62	2	19454	50	RGS10,ITM2B
1.111e-02	-4.50	homeostatic process	biological process	GO:0042592	1456	9	18204	47	APOE,PPARD,TREM2,WNT5A,CXCL12,APOC2,ABCB4,MEF2C,AXL
1.119e-02	-4.49	SAB	pfam domains	PF04382	4	1	17795	50	EPB41L2
1.119e-02	-4.49	CaKB	pfam domains	PF03185	4	1	17795	50	KCNMB1
1.119e-02	-4.49	4_1_CTD	pfam domains	PF05902	4	1	17795	50	EPB41L2
1.119e-02	-4.49	Apolipoprotein	pfam domains	PF01442	4	1	17795	50	APOE
1.119e-02	-4.49	HJURP_C	pfam domains	PF12347	4	1	17795	50	MEF2C
1.119e-02	-4.49	CortBP2	pfam domains	PF09727	4	1	17795	50	FILIP1L
1.138e-02	-4.48	negative regulation of cell projection organization	biological process	GO:0031345	181	3	18204	47	APOE,SPP1,WNT5A
1.138e-02	-4.48	Ig_V-set	interpro domains	IPR013106	173	3	18521	50	SIGLEC8,HAVCR2,TREM2
1.144e-02	-4.47	SPARC (secreted protein acidic and cysteine rich)	protein interactions	6678	63	2	19454	50	PDGFA,COL18A1
1.144e-02	-4.47	TSC22D2 (TSC22 domain family member 2)	protein interactions	9819	63	2	19454	50	OSBPL1A,WDR77
1.144e-02	-4.47	FITM2 (fat storage inducing transmembrane protein 2)	protein interactions	128486	63	2	19454	50	TSPAN15,C3AR1
1.144e-02	-4.47	HSDL1 (hydroxysteroid dehydrogenase like 1)	protein interactions	83693	63	2	19454	50	TSPAN15,C3AR1
1.146e-02	-4.47	vesicle	cellular component	GO:0031982	4141	18	19108	49	HAVCR2,COL18A1,OSBPL1A,SPP1,ITM2B,APOC2,ABCB4,WNT5A,RNASET2,EPB41L2,ACY3,CXCL12,TSPAN15,AXL,C3AR1,APOE,CD68,PDGFA
1.147e-02	-4.47	Bile acid and bile salt metabolism	REACTOME pathways	R-HSA-194068	43	2	10285	39	OSBPL1A,CH25H
1.147e-02	-4.47	Signaling by Retinoic Acid	REACTOME pathways	R-HSA-5362517	43	2	10285	39	PPARD,DHRS9
1.153e-02	-4.46	glandular epithelial cell differentiation	biological process	GO:0002067	63	2	18204	47	WDR77,WNT5A
1.155e-02	-4.46	regulation of cytokine-mediated signaling pathway	biological process	GO:0001959	182	3	18204	47	WNT5A,TREM2,AXL
1.160e-02	-4.46	synapse	cellular component	GO:0045202	1473	9	19108	49	APOE,MEF2C,RGS10,C1QC,WNT5A,ADORA3,C1QA,C1QB,KCNMB1
1.162e-02	-4.46	positive regulation of gene expression	biological process	GO:0010628	1212	8	18204	47	MEF2C,CSF1R,HAVCR2,WDR77,PPARD,C3AR1,TREM2,WNT5A
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	CSF1R,AXL
1.179e-02	-4.44	NAT14 (N-acetyltransferase 14 (putative))	protein interactions	57106	64	2	19454	50	C3AR1,TSPAN15
1.179e-02	-4.44	MICOS13 (mitochondrial contact site and cristae organizing system subunit 13)	protein interactions	125988	64	2	19454	50	APOC2,APOC1
1.179e-02	-4.44	ND5 (NADH dehydrogenase subunit 5)	protein interactions	4540	64	2	19454	50	TSPAN15,GPR34
1.179e-02	-4.44	SLC25A17 (solute carrier family 25 member 17)	protein interactions	10478	64	2	19454	50	TSPAN15,C3AR1
1.186e-02	-4.43	regulation of response to biotic stimulus	biological process	GO:0002831	534	5	18204	47	HAVCR2,APOE,ALPK1,TREM2,WNT5A
1.198e-02	-4.42	membrane	cellular component	GO:0016020	9220	32	19108	49	P2RY13,ABCB4,CSF2RA,HAVCR2,DCBLD1,CSF1R,EPB41L2,RGL3,FOLR2,APOE,ADAP2,CD68,CH25H,DHRS9,SIGLEC8,WNT5A,TREM2,RGS10,ADORA3,ITM2B,IFITM10,OSBPL1A,ACY3,CXCL12,AXL,TSPAN15,LTC4S,C3AR1,PDGFA,FILIP1L,KCNMB1,GPR34
1.199e-02	-4.42	Retinoid metabolism and transport	REACTOME pathways	R-HSA-975634	44	2	10285	39	APOC2,APOE
1.209e-02	-4.42	LAMP_3	prosite domains	PS51407	4	1	12186	37	CD68
1.214e-02	-4.41	CCR1 (C-C motif chemokine receptor 1)	protein interactions	1230	348	4	19454	50	ANKRD22,C1QC,DHRS9,C1QB
1.224e-02	-4.40	heart looping	biological process	GO:0001947	65	2	18204	47	MEF2C,WNT5A
1.224e-02	-4.40	forebrain cell migration	biological process	GO:0021885	65	2	18204	47	AXL,CXCL12
1.242e-02	-4.39	cell maturation	biological process	GO:0048469	187	3	18204	47	AXL,C1QA,WDR77
1.250e-02	-4.38	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	2	19454	50	DHRS9,APOE
1.250e-02	-4.38	AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4)	protein interactions	56895	66	2	19454	50	TSPAN15,C3AR1
1.250e-02	-4.38	LCN6 (lipocalin 6)	protein interactions	158062	66	2	19454	50	HS3ST1,WNT5A
1.250e-02	-4.38	COL4A2 (collagen type IV alpha 2 chain)	protein interactions	1284	66	2	19454	50	C1QC,C1QB
1.260e-02	-4.37	intracellular receptor signaling pathway	biological process	GO:0030522	188	3	18204	47	HAVCR2,ALPK1,PPARD
1.260e-02	-4.37	astrocyte differentiation	biological process	GO:0048708	66	2	18204	47	TREM2,C1QA
1.260e-02	-4.37	positive regulation of non-canonical NF-kappaB signal transduction	biological process	GO:1901224	66	2	18204	47	TREM2,HAVCR2
1.260e-02	-4.37	regulation of lipid catabolic process	biological process	GO:0050994	66	2	18204	47	APOC1,APOC2
1.260e-02	-4.37	myeloid cell activation involved in immune response	biological process	GO:0002275	66	2	18204	47	HAVCR2,TREM2
1.260e-02	-4.37	animal organ regeneration	biological process	GO:0031100	66	2	18204	47	AXL,CXCL12
1.260e-02	-4.37	regulation of morphogenesis of an epithelium	biological process	GO:1905330	66	2	18204	47	WNT5A,PDGFA
1.262e-02	-4.37	Ig-like_fold	interpro domains	IPR013783	721	6	18521	50	SIGLEC8,CSF2RA,AXL,CSF1R,HAVCR2,TREM2
1.275e-02	-4.36	regulation of cellular component size	biological process	GO:0032535	352	4	18204	47	WNT5A,APOE,CXCL12,SPP1
1.278e-02	-4.36	positive regulation of vasculature development	biological process	GO:1904018	189	3	18204	47	WNT5A,CXCL12,C3AR1
1.279e-02	-4.36	Cdkn2a (cyclin dependent kinase inhibitor 2A)	protein interactions	12578	5	1	19454	50	PDGFA
1.279e-02	-4.36	DSEL (dermatan sulfate epimerase like)	protein interactions	92126	5	1	19454	50	SPP1
1.279e-02	-4.36	SLC25A47 (solute carrier family 25 member 47)	protein interactions	283600	5	1	19454	50	C1QA
1.284e-02	-4.35	negative regulation of fat cell proliferation	biological process	GO:0070345	5	1	18204	47	TREM2
1.284e-02	-4.35	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	47	APOE
1.284e-02	-4.35	toll-like receptor 7 signaling pathway	biological process	GO:0034154	5	1	18204	47	HAVCR2
1.284e-02	-4.35	mammary gland branching involved in thelarche	biological process	GO:0060744	5	1	18204	47	WNT5A
1.284e-02	-4.35	negative regulation of response to tumor cell	biological process	GO:0002835	5	1	18204	47	HAVCR2
1.284e-02	-4.35	regulation of protein kinase C activity	biological process	GO:1900019	5	1	18204	47	WNT5A
1.284e-02	-4.35	positive regulation of hair follicle maturation	biological process	GO:0048818	5	1	18204	47	WNT5A
1.284e-02	-4.35	regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	biological process	GO:0002580	5	1	18204	47	TREM2
1.284e-02	-4.35	positive regulation of macrophage fusion	biological process	GO:0034241	5	1	18204	47	TREM2
1.284e-02	-4.35	convergent extension involved in organogenesis	biological process	GO:0060029	5	1	18204	47	WNT5A
1.284e-02	-4.35	epithelial-mesenchymal cell signaling	biological process	GO:0060684	5	1	18204	47	PDGFA
1.284e-02	-4.35	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	47	APOE
1.284e-02	-4.35	convergent extension involved in axis elongation	biological process	GO:0060028	5	1	18204	47	WNT5A
1.284e-02	-4.35	branch elongation involved in mammary gland duct branching	biological process	GO:0060751	5	1	18204	47	WNT5A
1.284e-02	-4.35	microglial cell activation involved in immune response	biological process	GO:0002282	5	1	18204	47	TREM2
1.284e-02	-4.35	regulation of macrophage fusion	biological process	GO:0034239	5	1	18204	47	TREM2
1.284e-02	-4.35	regulation of hippocampal neuron apoptotic process	biological process	GO:0110089	5	1	18204	47	TREM2
1.284e-02	-4.35	androgen catabolic process	biological process	GO:0006710	5	1	18204	47	SPP1
1.284e-02	-4.35	regulation of myeloid dendritic cell activation	biological process	GO:0030885	5	1	18204	47	HAVCR2
1.284e-02	-4.35	regulation of phosphatidylinositol biosynthetic process	biological process	GO:0010511	5	1	18204	47	PDGFA
1.284e-02	-4.35	negative regulation of melanin biosynthetic process	biological process	GO:0048022	5	1	18204	47	WNT5A
1.284e-02	-4.35	negative regulation of secondary metabolite biosynthetic process	biological process	GO:1900377	5	1	18204	47	WNT5A
1.284e-02	-4.35	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	47	APOE
1.284e-02	-4.35	regulation of timing of anagen	biological process	GO:0051884	5	1	18204	47	WNT5A
1.284e-02	-4.35	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	47	APOE
1.284e-02	-4.35	detection of lipopolysaccharide	biological process	GO:0032497	5	1	18204	47	TREM2
1.284e-02	-4.35	negative regulation of phospholipid biosynthetic process	biological process	GO:0071072	5	1	18204	47	PDGFA
1.284e-02	-4.35	thelarche	biological process	GO:0042695	5	1	18204	47	WNT5A
1.284e-02	-4.35	negative regulation of defense response to bacterium	biological process	GO:1900425	5	1	18204	47	HAVCR2
1.284e-02	-4.35	positive regulation of skeletal muscle tissue regeneration	biological process	GO:0043415	5	1	18204	47	PPARD
1.284e-02	-4.35	sphingolipid translocation	biological process	GO:0099039	5	1	18204	47	ABCB4
1.284e-02	-4.35	positive regulation of protein kinase C activity	biological process	GO:1900020	5	1	18204	47	WNT5A
1.284e-02	-4.35	serotonergic neuron axon guidance	biological process	GO:0036515	5	1	18204	47	WNT5A
1.284e-02	-4.35	negative regulation of astrocyte activation	biological process	GO:0061889	5	1	18204	47	TREM2
1.284e-02	-4.35	positive regulation of phospholipid translocation	biological process	GO:0061092	5	1	18204	47	ABCB4
1.284e-02	-4.35	negative regulation of immune response to tumor cell	biological process	GO:0002838	5	1	18204	47	HAVCR2
1.284e-02	-4.35	regulation of granulocyte colony-stimulating factor production	biological process	GO:0071655	5	1	18204	47	HAVCR2
1.284e-02	-4.35	melanocyte proliferation	biological process	GO:0097325	5	1	18204	47	WNT5A
1.294e-02	-4.35	negative regulation of response to stimulus	biological process	GO:0048585	1760	10	18204	47	PPARD,HAVCR2,APOE,WNT5A,PDGFA,TREM2,RGS10,SPP1,CXCL12,TSPAN15
1.320e-02	-4.33	apolipoprotein A-I binding	molecular function	GO:0034186	5	1	18094	48	TREM2
1.320e-02	-4.33	aminoacylase activity	molecular function	GO:0004046	5	1	18094	48	ACY3
1.320e-02	-4.33	inositol 1,3,4,5 tetrakisphosphate binding	molecular function	GO:0043533	5	1	18094	48	ADAP2
1.320e-02	-4.33	lipoteichoic acid binding	molecular function	GO:0070891	5	1	18094	48	TREM2
1.320e-02	-4.33	leukotriene-C4 synthase activity	molecular function	GO:0004464	5	1	18094	48	LTC4S
1.320e-02	-4.33	G protein-coupled adenosine receptor activity	molecular function	GO:0001609	5	1	18094	48	ADORA3
1.320e-02	-4.33	MRF binding	molecular function	GO:0043426	5	1	18094	48	BHLHE41
1.320e-02	-4.33	opsonin receptor activity	molecular function	GO:0001847	5	1	18094	48	C3AR1
1.324e-02	-4.32	SLC19A2 (solute carrier family 19 member 2)	protein interactions	10560	68	2	19454	50	TSPAN15,C3AR1
1.333e-02	-4.32	multi-organism reproductive process	biological process	GO:0044703	192	3	18204	47	PPARD,HAVCR2,SPP1
1.343e-02	-4.31	Short_hematopoietin_rcpt_2_CS	interpro domains	IPR003532	5	1	18521	50	CSF2RA
1.343e-02	-4.31	TF_MADSbox	interpro domains	IPR002100	5	1	18521	50	MEF2C
1.343e-02	-4.31	Lamp2-like_luminal	interpro domains	IPR048528	5	1	18521	50	CD68
1.343e-02	-4.31	TF_MADSbox_sf	interpro domains	IPR036879	5	1	18521	50	MEF2C
1.343e-02	-4.31	Lysosome-assoc_membr_glycop	interpro domains	IPR002000	5	1	18521	50	CD68
1.343e-02	-4.31	Folate_rcpt	interpro domains	IPR004269	5	1	18521	50	FOLR2
1.359e-02	-4.30	negative regulation of developmental process	biological process	GO:0051093	1000	7	18204	47	PPARD,WDR77,C1QC,BHLHE41,WNT5A,TREM2,SPP1
1.362e-02	-4.30	cellular component disassembly	biological process	GO:0022411	359	4	18204	47	C1QA,TREM2,C1QC,C1QB
1.370e-02	-4.29	regulation of response to cytokine stimulus	biological process	GO:0060759	194	3	18204	47	WNT5A,TREM2,AXL
1.370e-02	-4.29	regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	biological process	GO:0002822	194	3	18204	47	MEF2C,TREM2,HAVCR2
1.371e-02	-4.29	regulation of lymphocyte migration	biological process	GO:2000401	69	2	18204	47	WNT5A,CXCL12
1.371e-02	-4.29	regulation of blood coagulation	biological process	GO:0030193	69	2	18204	47	PDGFA,APOE
1.371e-02	-4.29	regulation of lipase activity	biological process	GO:0060191	69	2	18204	47	APOC1,APOC2
1.371e-02	-4.29	triglyceride metabolic process	biological process	GO:0006641	69	2	18204	47	APOE,APOC1
1.371e-02	-4.29	cytoplasmic pattern recognition receptor signaling pathway	biological process	GO:0002753	69	2	18204	47	HAVCR2,ALPK1
1.371e-02	-4.29	PROXISOMEPAR	prints domains	PR01288	3	1	5227	24	PPARD
1.371e-02	-4.29	5LPOXGNASEAP	prints domains	PR00488	3	1	5227	24	LTC4S
1.374e-02	-4.29	regulation of biological quality	biological process	GO:0065008	2936	14	18204	47	MEF2C,KCNMB1,USP53,DHRS9,C3AR1,ABCB4,CSF1R,AXL,SPP1,CXCL12,TREM2,PDGFA,WNT5A,APOE
1.388e-02	-4.28	regulation of protein catabolic process	biological process	GO:0042176	361	4	18204	47	APOE,TREM2,TSPAN15,WNT5A
1.397e-02	-4.27	SRF-TF	pfam domains	PF00319	5	1	17795	50	MEF2C
1.397e-02	-4.27	Lamp	pfam domains	PF01299	5	1	17795	50	CD68
1.399e-02	-4.27	MANBA (mannosidase beta)	protein interactions	4126	70	2	19454	50	C1QB,C1QA
1.409e-02	-4.26	negative regulation of smooth muscle cell proliferation	biological process	GO:0048662	70	2	18204	47	APOE,MEF2C
1.409e-02	-4.26	determination of heart left/right asymmetry	biological process	GO:0061371	70	2	18204	47	WNT5A,MEF2C
1.433e-02	-4.25	Systemic lupus erythematosus	KEGG pathways	ko05322	132	3	7161	28	C1QA,C1QC,C1QB
1.433e-02	-4.25	Systemic lupus erythematosus	KEGG pathways	hsa05322	132	3	7161	28	C1QC,C1QA,C1QB
1.433e-02	-4.25	MADS	smart domains	SM00432	5	1	9717	28	MEF2C
1.437e-02	-4.24	SLC35F2 (solute carrier family 35 member F2)	protein interactions	54733	71	2	19454	50	TSPAN15,C3AR1
1.448e-02	-4.24	embryonic heart tube morphogenesis	biological process	GO:0003143	71	2	18204	47	MEF2C,WNT5A
1.448e-02	-4.24	regulation of hemostasis	biological process	GO:1900046	71	2	18204	47	APOE,PDGFA
1.479e-02	-4.21	immune response-regulating signaling pathway	biological process	GO:0002764	368	4	18204	47	MEF2C,ALPK1,HAVCR2,C3AR1
1.486e-02	-4.21	multi-multicellular organism process	biological process	GO:0044706	200	3	18204	47	PPARD,HAVCR2,SPP1
1.487e-02	-4.21	cellular response to calcium ion	biological process	GO:0071277	72	2	18204	47	WNT5A,MEF2C
1.487e-02	-4.21	positive regulation of interleukin-1 production	biological process	GO:0032732	72	2	18204	47	WNT5A,HAVCR2
1.506e-02	-4.20	negative regulation of inflammatory response	biological process	GO:0050728	201	3	18204	47	APOE,PPARD,TREM2
1.508e-02	-4.19	Adenosine P1 receptors	REACTOME pathways	R-HSA-417973	4	1	10285	39	ADORA3
1.509e-02	-4.19	HEMATOPO_REC_S_F2	prosite domains	PS01356	5	1	12186	37	CSF2RA
1.509e-02	-4.19	MADS_BOX_2	prosite domains	PS50066	5	1	12186	37	MEF2C
1.509e-02	-4.19	MADS_BOX_1	prosite domains	PS00350	5	1	12186	37	MEF2C
1.511e-02	-4.19	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	44	APOE
1.511e-02	-4.19	Transcription factor, MADS-box	gene3d domains	3.40.1810.10	5	1	14470	44	MEF2C
1.512e-02	-4.19	SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta)	protein interactions	54557	202	3	19454	50	SPP1,C1QA,CD68
1.515e-02	-4.19	MMP2 (matrix metallopeptidase 2)	protein interactions	4313	73	2	19454	50	CXCL12,COL18A1
1.521e-02	-4.19	human chr3q12.1	chromosome location	human chr3q12.1	8	1	26134	50	FILIP1L
1.524e-02	-4.18	phosphatidylserine binding	molecular function	GO:0001786	71	2	18094	48	AXL,TREM2
1.524e-02	-4.18	RNA endonuclease activity	molecular function	GO:0004521	71	2	18094	48	RNASET2,RNASEH1
1.526e-02	-4.18	intracellular calcium ion homeostasis	biological process	GO:0006874	202	3	18204	47	WNT5A,CXCL12,APOE
1.526e-02	-4.18	regulation of myoblast differentiation	biological process	GO:0045661	73	2	18204	47	PPARD,MEF2C
1.526e-02	-4.18	negative regulation of wound healing	biological process	GO:0061045	73	2	18204	47	PDGFA,APOE
1.526e-02	-4.18	negative regulation of reproductive process	biological process	GO:2000242	73	2	18204	47	WDR77,WNT5A
1.529e-02	-4.18	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	49	APOE
1.529e-02	-4.18	intercellular canaliculus	cellular component	GO:0046581	6	1	19108	49	ABCB4
1.529e-02	-4.18	Cul4B-RING E3 ubiquitin ligase complex	cellular component	GO:0031465	6	1	19108	49	WDR77
1.531e-02	-4.18	CERS2 (ceramide synthase 2)	protein interactions	29956	203	3	19454	50	TSPAN15,EPB41L2,C3AR1
1.532e-02	-4.18	Ncoa2 (nuclear receptor coactivator 2)	protein interactions	17978	6	1	19454	50	PPARD
1.532e-02	-4.18	PIGY (phosphatidylinositol glycan anchor biosynthesis class Y)	protein interactions	84992	6	1	19454	50	ABCB4
1.532e-02	-4.18	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	50	APOE
1.532e-02	-4.18	STAG3L4 (STAG3 cohesin complex component like 4 (pseudogene))	protein interactions	64940	6	1	19454	50	TSPAN15
1.532e-02	-4.18	FOLR3 (folate receptor gamma)	protein interactions	2352	6	1	19454	50	FOLR2
1.532e-02	-4.18	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	50	APOE
1.532e-02	-4.18	Dock11 (dedicator of cytokinesis 11)	protein interactions	75974	6	1	19454	50	EPB41L2
1.532e-02	-4.18	ZNF804A (zinc finger protein 804A)	protein interactions	91752	6	1	19454	50	SPP1
1.535e-02	-4.18	Immunoglobulin	interpro domains	IPR013151	70	2	18521	50	CSF1R,SIGLEC8
1.539e-02	-4.17	negative regulation of epithelial cell proliferation involved in prostate gland development	biological process	GO:0060770	6	1	18204	47	WDR77
1.539e-02	-4.17	neutrophil clearance	biological process	GO:0097350	6	1	18204	47	AXL
1.539e-02	-4.17	regulation of CD40 signaling pathway	biological process	GO:2000348	6	1	18204	47	TREM2
1.539e-02	-4.17	negative regulation of interferon-alpha production	biological process	GO:0032687	6	1	18204	47	HAVCR2
1.539e-02	-4.17	regulation of macrophage inflammatory protein 1 alpha production	biological process	GO:0071640	6	1	18204	47	TREM2
1.539e-02	-4.17	regulation of response to macrophage colony-stimulating factor	biological process	GO:1903969	6	1	18204	47	TREM2
1.539e-02	-4.17	bile acid secretion	biological process	GO:0032782	6	1	18204	47	ABCB4
1.539e-02	-4.17	cellular response to peptidoglycan	biological process	GO:0071224	6	1	18204	47	TREM2
1.539e-02	-4.17	dopaminergic neuron axon guidance	biological process	GO:0036514	6	1	18204	47	WNT5A
1.539e-02	-4.17	positive regulation of dopamine secretion	biological process	GO:0033603	6	1	18204	47	CXCL12
1.539e-02	-4.17	positive regulation of protein localization to synapse	biological process	GO:1902474	6	1	18204	47	WNT5A
1.539e-02	-4.17	planar cell polarity pathway involved in axis elongation	biological process	GO:0003402	6	1	18204	47	WNT5A
1.539e-02	-4.17	positive regulation of macrophage proliferation	biological process	GO:0120041	6	1	18204	47	CSF1R
1.539e-02	-4.17	negative regulation of sequestering of triglyceride	biological process	GO:0010891	6	1	18204	47	TREM2
1.539e-02	-4.17	regulation of antigen processing and presentation of peptide antigen	biological process	GO:0002583	6	1	18204	47	TREM2
1.539e-02	-4.17	positive regulation of protein localization to cell cortex	biological process	GO:1904778	6	1	18204	47	EPB41L2
1.539e-02	-4.17	chemorepulsion of axon	biological process	GO:0061643	6	1	18204	47	WNT5A
1.539e-02	-4.17	regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	biological process	GO:2001188	6	1	18204	47	HAVCR2
1.539e-02	-4.17	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	47	APOE
1.539e-02	-4.17	regulation of phospholipid translocation	biological process	GO:0061091	6	1	18204	47	ABCB4
1.539e-02	-4.17	regulation of cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:1903972	6	1	18204	47	TREM2
1.539e-02	-4.17	cell surface receptor signaling pathway involved in heart development	biological process	GO:0061311	6	1	18204	47	WNT5A
1.539e-02	-4.17	regulation of synapse pruning	biological process	GO:1905806	6	1	18204	47	TREM2
1.539e-02	-4.17	keratinocyte migration	biological process	GO:0051546	6	1	18204	47	PPARD
1.539e-02	-4.17	regulation of prostatic bud formation	biological process	GO:0060685	6	1	18204	47	WNT5A
1.539e-02	-4.17	B cell chemotaxis	biological process	GO:0035754	6	1	18204	47	CH25H
1.539e-02	-4.17	regulation of very-low-density lipoprotein particle remodeling	biological process	GO:0010901	6	1	18204	47	APOC2
1.552e-02	-4.17	LPAR1 (lysophosphatidic acid receptor 1)	protein interactions	1902	204	3	19454	50	AXL,C3AR1,TSPAN15
1.554e-02	-4.16	LPCAT3 (lysophosphatidylcholine acyltransferase 3)	protein interactions	10162	74	2	19454	50	TSPAN15,C3AR1
1.554e-02	-4.16	NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1)	protein interactions	4707	74	2	19454	50	C3AR1,GPR34
1.554e-02	-4.16	SYNGR2 (synaptogyrin 2)	protein interactions	9144	74	2	19454	50	ANKRD22,TSPAN15
1.558e-02	-4.16	regulation of leukocyte activation	biological process	GO:0002694	572	5	18204	47	MEF2C,AXL,TREM2,WNT5A,HAVCR2
1.566e-02	-4.16	regulation of coagulation	biological process	GO:0050818	74	2	18204	47	PDGFA,APOE
1.566e-02	-4.16	positive regulation of protein localization to cell periphery	biological process	GO:1904377	74	2	18204	47	EPB41L2,TREM2
1.566e-02	-4.16	positive regulation of protein catabolic process	biological process	GO:0045732	204	3	18204	47	APOE,WNT5A,TREM2
1.581e-02	-4.15	RNA-DNA hybrid ribonuclease activity	molecular function	GO:0004523	6	1	18094	48	RNASEH1
1.581e-02	-4.15	sulfatide binding	molecular function	GO:0120146	6	1	18094	48	TREM2
1.587e-02	-4.14	clathrin-coated endocytic vesicle membrane	cellular component	GO:0030669	75	2	19108	49	APOE,WNT5A
1.594e-02	-4.14	NPTX1 (neuronal pentraxin 1)	protein interactions	4884	75	2	19454	50	WNT5A,C1QA
1.594e-02	-4.14	ATP9A (ATPase phospholipid transporting 9A (putative))	protein interactions	10079	75	2	19454	50	C3AR1,TSPAN15
1.600e-02	-4.13	PDGFRA (platelet derived growth factor receptor alpha)	protein interactions	5156	378	4	19454	50	PDGFA,WNT5A,HS3ST1,COL18A1
1.606e-02	-4.13	regulation of behavior	biological process	GO:0050795	75	2	18204	47	MEF2C,APOE
1.609e-02	-4.13	LCCL	interpro domains	IPR004043	6	1	18521	50	DCBLD1
1.609e-02	-4.13	MAPEG-like_dom_sf	interpro domains	IPR023352	6	1	18521	50	LTC4S
1.609e-02	-4.13	LCCL_sf	interpro domains	IPR036609	6	1	18521	50	DCBLD1
1.609e-02	-4.13	a-kinase_dom	interpro domains	IPR004166	6	1	18521	50	ALPK1
1.609e-02	-4.13	Fatty_acid_hydroxylase	interpro domains	IPR006694	6	1	18521	50	CH25H
1.609e-02	-4.13	Membr-assoc_MAPEG	interpro domains	IPR001129	6	1	18521	50	LTC4S
1.635e-02	-4.11	LMBR1 (limb development membrane protein 1)	protein interactions	64327	76	2	19454	50	TSPAN15,C3AR1
1.635e-02	-4.11	BCL2L2 (BCL2 like 2)	protein interactions	599	76	2	19454	50	APOC2,APOC1
1.635e-02	-4.11	CD1B (CD1b molecule)	protein interactions	910	76	2	19454	50	ALPK1,ITM2B
1.647e-02	-4.11	positive regulation of type II interferon production	biological process	GO:0032729	76	2	18204	47	WNT5A,HAVCR2
1.655e-02	-4.10	ig	pfam domains	PF00047	70	2	17795	50	SIGLEC8,CSF1R
1.656e-02	-4.10	leukotriene biosynthesis	BIOCYC pathways	META_PWY66-375	5	1	902	3	LTC4S
1.656e-02	-4.10	leukotriene biosynthesis	BIOCYC pathways	HUMAN_PWY66-375	5	1	902	3	LTC4S
1.660e-02	-4.10	negative regulation of cell migration	biological process	GO:0030336	381	4	18204	47	APOE,CXCL12,ADORA3,MEF2C
1.670e-02	-4.09	regulation of adaptive immune response	biological process	GO:0002819	209	3	18204	47	MEF2C,TREM2,HAVCR2
1.672e-02	-4.09	multicellular organism development	biological process	GO:0007275	3957	17	18204	47	MEF2C,C1QA,ADAP2,COL18A1,BHLHE41,HAVCR2,CSF1R,AXL,SPP1,CXCL12,TREM2,PDGFA,WNT5A,ITM2B,WDR77,APOE,PPARD
1.674e-02	-4.09	MAPEG	pfam domains	PF01124	6	1	17795	50	LTC4S
1.674e-02	-4.09	Alpha_kinase	pfam domains	PF02816	6	1	17795	50	ALPK1
1.674e-02	-4.09	LCCL	pfam domains	PF03815	6	1	17795	50	DCBLD1
1.674e-02	-4.09	FA_hydroxylase	pfam domains	PF04116	6	1	17795	50	CH25H
1.676e-02	-4.09	LRRC8A (leucine rich repeat containing 8 VRAC subunit A)	protein interactions	56262	77	2	19454	50	TSPAN15,C3AR1
1.676e-02	-4.09	FKBP2 (FKBP prolyl isomerase 2)	protein interactions	2286	77	2	19454	50	EPB41L2,C1QC
1.688e-02	-4.08	negative regulation of endocytosis	biological process	GO:0045806	77	2	18204	47	APOC2,APOC1
1.692e-02	-4.08	Integrins in angiogenesis	Pathway Interaction DB	avb3_integrin_pathway	46	2	2226	10	CSF1R,SPP1
1.704e-02	-4.07	cytokine-mediated signaling pathway	biological process	GO:0019221	384	4	18204	47	TREM2,CSF1R,CSF2RA,CXCL12
1.709e-02	-4.07	Metabolism of fat-soluble vitamins	REACTOME pathways	R-HSA-6806667	53	2	10285	39	APOE,APOC2
1.717e-02	-4.06	Nedd4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	25489	78	2	19454	50	PPARD,ADAP2
1.717e-02	-4.06	Alpha_kinase	smart domains	SM00811	6	1	9717	28	ALPK1
1.717e-02	-4.06	LCCL	smart domains	SM00603	6	1	9717	28	DCBLD1
1.730e-02	-4.06	negative regulation of endothelial cell proliferation	biological process	GO:0001937	78	2	18204	47	APOE,MEF2C
1.734e-02	-4.05	positive regulation of monoatomic ion transport	biological process	GO:0043270	212	3	18204	47	KCNMB1,CXCL12,TREM2
1.759e-02	-4.04	NUCB2 (nucleobindin 2)	protein interactions	4925	79	2	19454	50	TREM2,AXL
1.759e-02	-4.04	CIB2 (calcium and integrin binding family member 2)	protein interactions	10518	79	2	19454	50	RGL3,AXL
1.759e-02	-4.04	NCS1 (neuronal calcium sensor 1)	protein interactions	23413	79	2	19454	50	SPP1,RNASEH1
1.772e-02	-4.03	energy homeostasis	biological process	GO:0097009	79	2	18204	47	PPARD,APOE
1.786e-02	-4.03	MFSD9 (major facilitator superfamily domain containing 9)	protein interactions	84804	7	1	19454	50	TSPAN15
1.786e-02	-4.03	SLC5A1 (solute carrier family 5 member 1)	protein interactions	6523	7	1	19454	50	AXL
1.786e-02	-4.03	SLC25A52 (solute carrier family 25 member 52)	protein interactions	147407	7	1	19454	50	TSPAN15
1.786e-02	-4.03	CR1 (complement C3b/C4b receptor 1 (Knops blood group))	protein interactions	1378	7	1	19454	50	C1QA
1.786e-02	-4.03	Rtf2 (replication termination factor 2)	protein interactions	66404	7	1	19454	50	BHLHE41
1.786e-02	-4.03	ALG1L1P (ALG1 like 1, pseudogene)	protein interactions	200810	7	1	19454	50	RGL3
1.786e-02	-4.03	RIMS4 (regulating synaptic membrane exocytosis 4)	protein interactions	140730	7	1	19454	50	SPP1
1.786e-02	-4.03	CIMIP2A (ciliary microtubule inner protein 2A)	protein interactions	401565	7	1	19454	50	ACY3
1.786e-02	-4.03	Gadd45b (growth arrest and DNA-damage-inducible 45 beta)	protein interactions	17873	7	1	19454	50	PPARD
1.786e-02	-4.03	SOX18 (SRY-box transcription factor 18)	protein interactions	54345	7	1	19454	50	MEF2C
1.793e-02	-4.02	regulation of immune effector process	biological process	GO:0002697	390	4	18204	47	HAVCR2,WNT5A,AXL,TREM2
1.794e-02	-4.02	development of secondary female sexual characteristics	biological process	GO:0046543	7	1	18204	47	WNT5A
1.794e-02	-4.02	negative regulation of lipoprotein lipase activity	biological process	GO:0051005	7	1	18204	47	APOC1
1.794e-02	-4.02	platelet-derived growth factor receptor-beta signaling pathway	biological process	GO:0035791	7	1	18204	47	PDGFA
1.794e-02	-4.02	retinoic acid biosynthetic process	biological process	GO:0002138	7	1	18204	47	DHRS9
1.794e-02	-4.02	positive regulation of complement activation	biological process	GO:0045917	7	1	18204	47	TREM2
1.794e-02	-4.02	positive regulation of microglial cell migration	biological process	GO:1904141	7	1	18204	47	TREM2
1.794e-02	-4.02	optic cup morphogenesis involved in camera-type eye development	biological process	GO:0002072	7	1	18204	47	WNT5A
1.794e-02	-4.02	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	47	APOE
1.794e-02	-4.02	fat cell proliferation	biological process	GO:0070341	7	1	18204	47	PPARD
1.794e-02	-4.02	positive regulation of lipoprotein lipase activity	biological process	GO:0051006	7	1	18204	47	APOC2
1.794e-02	-4.02	regulation of macrophage colony-stimulating factor production	biological process	GO:1901256	7	1	18204	47	HAVCR2
1.794e-02	-4.02	positive regulation of high-density lipoprotein particle clearance	biological process	GO:0010983	7	1	18204	47	TREM2
1.794e-02	-4.02	regulation of macrophage proliferation	biological process	GO:0120040	7	1	18204	47	CSF1R
1.794e-02	-4.02	paraxial mesoderm formation	biological process	GO:0048341	7	1	18204	47	WNT5A
1.794e-02	-4.02	positive regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002925	7	1	18204	47	TREM2
1.794e-02	-4.02	positive regulation of skeletal muscle cell differentiation	biological process	GO:2001016	7	1	18204	47	MEF2C
1.794e-02	-4.02	positive regulation of pinocytosis	biological process	GO:0048549	7	1	18204	47	AXL
1.794e-02	-4.02	convergent extension involved in gastrulation	biological process	GO:0060027	7	1	18204	47	WNT5A
1.794e-02	-4.02	regulation of inward rectifier potassium channel activity	biological process	GO:1901979	7	1	18204	47	TREM2
1.794e-02	-4.02	positive regulation of axon extension involved in axon guidance	biological process	GO:0048842	7	1	18204	47	CXCL12
1.794e-02	-4.02	response to hydrostatic pressure	biological process	GO:0051599	7	1	18204	47	COL18A1
1.794e-02	-4.02	hindgut morphogenesis	biological process	GO:0007442	7	1	18204	47	WNT5A
1.794e-02	-4.02	negative regulation of mesenchymal cell proliferation	biological process	GO:0072201	7	1	18204	47	WNT5A
1.794e-02	-4.02	negative regulation of toll-like receptor 2 signaling pathway	biological process	GO:0034136	7	1	18204	47	TREM2
1.794e-02	-4.02	positive regulation of behavioral fear response	biological process	GO:2000987	7	1	18204	47	MEF2C
1.801e-02	-4.02	COL6A2 (collagen type VI alpha 2 chain)	protein interactions	1292	80	2	19454	50	C1QB,C1QC
1.801e-02	-4.02	CEACAM21 (CEA cell adhesion molecule 21)	protein interactions	90273	80	2	19454	50	ITM2B,HS3ST1
1.808e-02	-4.01	ALPHA_KINASE	prosite domains	PS51158	6	1	12186	37	ALPK1
1.808e-02	-4.01	LCCL	prosite domains	PS50820	6	1	12186	37	DCBLD1
1.811e-02	-4.01	MHCK/EF2 kinase	gene3d domains	3.20.200.10	6	1	14470	44	ALPK1
1.811e-02	-4.01	LCCL-like domain	gene3d domains	2.170.130.20	6	1	14470	44	DCBLD1
1.811e-02	-4.01	Membrane associated eicosanoid/glutathione metabolism-like domain	gene3d domains	1.20.120.550	6	1	14470	44	LTC4S
1.811e-02	-4.01	-	gene3d domains	2.40.160.110	6	1	14470	44	CD68
1.814e-02	-4.01	negative regulation of NF-kappaB transcription factor activity	biological process	GO:0032088	80	2	18204	47	HAVCR2,ADORA3
1.821e-02	-4.01	cell chemotaxis	biological process	GO:0060326	216	3	18204	47	CH25H,FOLR2,CXCL12
1.821e-02	-4.01	regulation of myeloid cell differentiation	biological process	GO:0045637	216	3	18204	47	TREM2,MEF2C,C1QC
1.825e-02	-4.00	LYSASSOCTDMP	prints domains	PR00336	4	1	5227	24	CD68
1.825e-02	-4.00	ADENOSINER	prints domains	PR00424	4	1	5227	24	ADORA3
1.833e-02	-4.00	endosome	cellular component	GO:0005768	1067	7	19108	49	ITM2B,OSBPL1A,HAVCR2,APOC2,APOE,CD68,TSPAN15
1.835e-02	-4.00	PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)	protein interactions	5295	394	4	19454	50	HAVCR2,CSF1R,CSF2RA,AXL
1.843e-02	-3.99	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	molecular function	GO:0008467	7	1	18094	48	HS3ST1
1.843e-02	-3.99	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen	molecular function	GO:0016716	7	1	18094	48	CH25H
1.843e-02	-3.99	SLC30A7 (solute carrier family 30 member 7)	protein interactions	148867	81	2	19454	50	WNT5A,TSPAN15
1.857e-02	-3.99	outflow tract morphogenesis	biological process	GO:0003151	81	2	18204	47	MEF2C,WNT5A
1.865e-02	-3.98	leukocyte activation	biological process	GO:0045321	599	5	18204	47	TREM2,MEF2C,AXL,C1QA,HAVCR2
1.875e-02	-3.98	PD_growth_factor_CS	interpro domains	IPR023581	7	1	18521	50	PDGFA
1.881e-02	-3.97	clathrin-coated vesicle	cellular component	GO:0030136	220	3	19108	49	ABCB4,APOE,WNT5A
1.882e-02	-3.97	VLDL biosynthesis	REACTOME pathways	R-HSA-8866423	5	1	10285	39	APOC1
1.885e-02	-3.97	negative regulation of cell motility	biological process	GO:2000146	396	4	18204	47	ADORA3,MEF2C,APOE,CXCL12
1.886e-02	-3.97	Innate Immune System	REACTOME pathways	R-HSA-168249	1285	10	10285	39	PDGFA,C3AR1,C1QA,RNASET2,CD68,C1QC,CSF2RA,C1QB,MEF2C,TREM2
1.886e-02	-3.97	MSMO1 (methylsterol monooxygenase 1)	protein interactions	6307	82	2	19454	50	TSPAN15,C3AR1
1.901e-02	-3.96	response to vitamin	biological process	GO:0033273	82	2	18204	47	SPP1,FOLR2
1.901e-02	-3.96	negative regulation of blood vessel endothelial cell migration	biological process	GO:0043537	82	2	18204	47	MEF2C,APOE
1.911e-02	-3.96	regulation of peptidyl-tyrosine phosphorylation	biological process	GO:0050730	220	3	18204	47	PDGFA,CSF1R,TREM2
1.916e-02	-3.95	SCGB2A2 (secretoglobin family 2A member 2)	protein interactions	4250	221	3	19454	50	COL18A1,TREM2,WNT5A
1.917e-02	-3.95	organic anion transport	biological process	GO:0015711	398	4	18204	47	ABCB4,PPARD,APOE,FOLR2
1.934e-02	-3.95	leukocyte mediated immunity	biological process	GO:0002443	221	3	18204	47	C1QA,C1QC,C1QB
1.944e-02	-3.94	regulation of amine transport	biological process	GO:0051952	83	2	18204	47	CXCL12,ADORA3
1.944e-02	-3.94	positive regulation of MAP kinase activity	biological process	GO:0043406	83	2	18204	47	PDGFA,WNT5A
1.954e-02	-3.94	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	48	AXL,CSF1R
1.964e-02	-3.93	regulation of cell growth	biological process	GO:0001558	401	4	18204	47	SPP1,APOE,CXCL12,WNT5A
1.974e-02	-3.93	IQSEC1 (IQ motif and Sec7 domain ArfGEF 1)	protein interactions	9922	84	2	19454	50	HAVCR2,APOE
1.974e-02	-3.93	P3H3 (prolyl 3-hydroxylase 3)	protein interactions	10536	84	2	19454	50	C1QB,C1QA
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	CSF1R,AXL
1.976e-02	-3.92	neurogenesis	biological process	GO:0022008	1334	8	18204	47	CSF1R,MEF2C,AXL,C1QA,CXCL12,WNT5A,TREM2,APOE
1.983e-02	-3.92	Cytokine-cytokine receptor interaction	KEGG pathways	hsa04060	270	4	7161	28	CXCL12,PDGFA,CSF2RA,CSF1R
1.983e-02	-3.92	Cytokine-cytokine receptor interaction	KEGG pathways	ko04060	270	4	7161	28	CSF2RA,PDGFA,CXCL12,CSF1R
1.989e-02	-3.92	chemokine-mediated signaling pathway	biological process	GO:0070098	84	2	18204	47	TREM2,CXCL12
1.999e-02	-3.91	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	47	WNT5A,MEF2C,RGL3,PPARD,C3AR1,APOE
2.004e-02	-3.91	neuron projection guidance	biological process	GO:0097485	224	3	18204	47	CSF1R,WNT5A,CXCL12
2.004e-02	-3.91	axon guidance	biological process	GO:0007411	224	3	18204	47	CXCL12,CSF1R,WNT5A
2.032e-02	-3.90	ECSIT (ECSIT signaling integrator)	protein interactions	51295	226	3	19454	50	APOE,TSPAN15,C3AR1
2.032e-02	-3.90	PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)	protein interactions	5296	226	3	19454	50	HAVCR2,CSF1R,AXL
2.033e-02	-3.90	embryonic heart tube development	biological process	GO:0035050	85	2	18204	47	MEF2C,WNT5A
2.034e-02	-3.90	growth factor complex	cellular component	GO:0036454	8	1	19108	49	PDGFA
2.034e-02	-3.90	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	49	APOC2
2.038e-02	-3.89	SLC38A3 (solute carrier family 38 member 3)	protein interactions	10991	8	1	19454	50	TSPAN15
2.038e-02	-3.89	SFTPA1 (surfactant protein A1)	protein interactions	653509	8	1	19454	50	C1QA
2.038e-02	-3.89	ASPA (aspartoacylase)	protein interactions	443	8	1	19454	50	ACY3
2.042e-02	-3.89	enzyme regulator activity	molecular function	GO:0030234	1305	8	18094	48	RGS10,LTC4S,TREM2,RGL3,APOC1,ADAP2,APOE,APOC2
2.047e-02	-3.89	negative regulation of macrophage differentiation	biological process	GO:0045650	8	1	18204	47	C1QC
2.047e-02	-3.89	positive regulation of triglyceride catabolic process	biological process	GO:0010898	8	1	18204	47	APOC2
2.047e-02	-3.89	positive regulation of natural killer cell differentiation	biological process	GO:0032825	8	1	18204	47	AXL
2.047e-02	-3.89	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	47	APOE
2.047e-02	-3.89	pericardium morphogenesis	biological process	GO:0003344	8	1	18204	47	WNT5A
2.047e-02	-3.89	cellular response to interferon-alpha	biological process	GO:0035457	8	1	18204	47	AXL
2.047e-02	-3.89	positive regulation of neuron projection arborization	biological process	GO:0150012	8	1	18204	47	WNT5A
2.047e-02	-3.89	positive regulation of triglyceride lipase activity	biological process	GO:0061365	8	1	18204	47	APOC2
2.047e-02	-3.89	positive regulation of apoptotic cell clearance	biological process	GO:2000427	8	1	18204	47	TREM2
2.047e-02	-3.89	cellular response to macrophage colony-stimulating factor stimulus	biological process	GO:0036006	8	1	18204	47	CSF1R
2.047e-02	-3.89	macrophage derived foam cell differentiation	biological process	GO:0010742	8	1	18204	47	WNT5A
2.047e-02	-3.89	G protein-coupled adenosine receptor signaling pathway	biological process	GO:0001973	8	1	18204	47	ADORA3
2.047e-02	-3.89	diterpenoid biosynthetic process	biological process	GO:0016102	8	1	18204	47	DHRS9
2.047e-02	-3.89	amyloid-beta clearance by cellular catabolic process	biological process	GO:0150094	8	1	18204	47	TREM2
2.047e-02	-3.89	regulation of microglial cell migration	biological process	GO:1904139	8	1	18204	47	TREM2
2.047e-02	-3.89	protein import	biological process	GO:0017038	8	1	18204	47	APOE
2.047e-02	-3.89	hindgut development	biological process	GO:0061525	8	1	18204	47	WNT5A
2.047e-02	-3.89	positive regulation of fear response	biological process	GO:1903367	8	1	18204	47	MEF2C
2.047e-02	-3.89	regulation of skeletal muscle tissue regeneration	biological process	GO:0043416	8	1	18204	47	PPARD
2.047e-02	-3.89	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	47	APOE
2.047e-02	-3.89	negative regulation of synapse assembly	biological process	GO:0051964	8	1	18204	47	WNT5A
2.047e-02	-3.89	oocyte axis specification	biological process	GO:0007309	8	1	18204	47	WDR77
2.047e-02	-3.89	regulation of astrocyte activation	biological process	GO:0061888	8	1	18204	47	TREM2
2.047e-02	-3.89	lateral sprouting from an epithelium	biological process	GO:0060601	8	1	18204	47	WNT5A
2.047e-02	-3.89	negative regulation of T-helper 1 type immune response	biological process	GO:0002826	8	1	18204	47	HAVCR2
2.047e-02	-3.89	regulation of germinal center formation	biological process	GO:0002634	8	1	18204	47	MEF2C
2.047e-02	-3.89	olfactory bulb interneuron development	biological process	GO:0021891	8	1	18204	47	WNT5A
2.047e-02	-3.89	negative regulation of p38MAPK cascade	biological process	GO:1903753	8	1	18204	47	TREM2
2.047e-02	-3.89	negative regulation of granulocyte differentiation	biological process	GO:0030853	8	1	18204	47	C1QC
2.047e-02	-3.89	oocyte construction	biological process	GO:0007308	8	1	18204	47	WDR77
2.047e-02	-3.89	negative regulation of morphogenesis of an epithelium	biological process	GO:1905331	8	1	18204	47	WNT5A
2.047e-02	-3.89	G protein-coupled purinergic receptor signaling pathway	biological process	GO:0035588	8	1	18204	47	ADORA3
2.047e-02	-3.89	cardiac ventricle formation	biological process	GO:0003211	8	1	18204	47	MEF2C
2.047e-02	-3.89	notochord morphogenesis	biological process	GO:0048570	8	1	18204	47	WNT5A
2.063e-02	-3.88	COL14A1 (collagen type XIV alpha 1 chain)	protein interactions	7373	86	2	19454	50	C1QC,PDGFA
2.078e-02	-3.87	regulation of potassium ion transmembrane transport	biological process	GO:1901379	86	2	18204	47	KCNMB1,TREM2
2.078e-02	-3.87	forebrain development	biological process	GO:0030900	408	4	18204	47	CXCL12,CSF1R,AXL,WNT5A
2.087e-02	-3.87	biological regulation	biological process	GO:0065007	12501	39	18204	47	COL18A1,RGL3,APOC1,C3AR1,BHLHE41,CH25H,C1QA,SIGLEC8,C1QB,KCNMB1,ITM2B,CSF2RA,PDGFA,WNT5A,PPARD,C1QC,APOE,WDR77,TSPAN15,AXL,SPP1,CXCL12,DHRS9,USP53,P2RY13,HAVCR2,CD68,ALPK1,ADAP2,ADORA3,MEF2C,GPR34,TREM2,CSF1R,ABCB4,APOC2,EPB41L2,RGS10,FOLR2
2.095e-02	-3.87	regionalization	biological process	GO:0003002	409	4	18204	47	BHLHE41,C1QA,MEF2C,WNT5A
2.103e-02	-3.86	phosphatidylcholine floppase activity	molecular function	GO:0090554	8	1	18094	48	ABCB4
2.103e-02	-3.86	PH domain binding	molecular function	GO:0042731	8	1	18094	48	EPB41L2
2.103e-02	-3.86	androsterone dehydrogenase activity	molecular function	GO:0047023	8	1	18094	48	DHRS9
2.103e-02	-3.86	testosterone dehydrogenase (NAD+) activity	molecular function	GO:0047035	8	1	18094	48	DHRS9
2.106e-02	-3.86	Immunoglobulins	gene3d domains	2.60.40.10	721	6	14470	44	HAVCR2,AXL,CSF1R,SIGLEC8,CSF2RA,TREM2
2.107e-02	-3.86	PDGF_1	prosite domains	PS00249	7	1	12186	37	PDGFA
2.108e-02	-3.86	MICA (MHC class I polypeptide-related sequence A)	protein interactions	100507436	87	2	19454	50	ITM2B,ADAP2
2.117e-02	-3.86	positive regulation of phosphorylation	biological process	GO:0042327	619	5	18204	47	PDGFA,WNT5A,CSF1R,TREM2,AXL
2.124e-02	-3.85	modulation by host of symbiont process	biological process	GO:0051851	87	2	18204	47	CSF1R,APOE
2.127e-02	-3.85	epithelium development	biological process	GO:0060429	1094	7	18204	47	MEF2C,CSF1R,WDR77,COL18A1,DHRS9,WNT5A,PDGFA
2.130e-02	-3.85	regulation of cell differentiation	biological process	GO:0045595	1622	9	18204	47	WNT5A,TREM2,PPARD,C1QC,BHLHE41,MEF2C,AXL,CXCL12,SPP1
2.139e-02	-3.84	antioxidant activity	molecular function	GO:0016209	85	2	18094	48	APOE,LTC4S
2.140e-02	-3.84	Folate_rcpt-like	interpro domains	IPR018143	8	1	18521	50	FOLR2
2.140e-02	-3.84	Tyr_kinase_rcpt_3_CS	interpro domains	IPR001824	8	1	18521	50	CSF1R
2.140e-02	-3.84	TypeI_recpt_CBD	interpro domains	IPR015321	8	1	18521	50	CSF2RA
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	CSF1R,AXL,HAVCR2,SIGLEC8
2.169e-02	-3.83	regulation of tissue remodeling	biological process	GO:0034103	88	2	18204	47	CSF1R,SPP1
2.171e-02	-3.83	cellular response to nutrient levels	biological process	GO:0031669	231	3	18204	47	PPARD,FOLR2,CD68
2.171e-02	-3.83	calcium ion homeostasis	biological process	GO:0055074	231	3	18204	47	CXCL12,APOE,WNT5A
2.194e-02	-3.82	cell motility	biological process	GO:0048870	1101	7	18204	47	CH25H,AXL,MEF2C,FOLR2,CXCL12,WNT5A,PPARD
2.196e-02	-3.82	connective tissue development	biological process	GO:0061448	232	3	18204	47	PPARD,WNT5A,MEF2C
2.203e-02	-3.82	TyrKc	smart domains	SM00219	80	2	9717	28	AXL,CSF1R
2.216e-02	-3.81	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	2	18204	47	APOE,APOC2
2.226e-02	-3.80	IL6Ra-bind	pfam domains	PF09240	8	1	17795	50	CSF2RA
2.226e-02	-3.80	Folate_rec	pfam domains	PF03024	8	1	17795	50	FOLR2
2.240e-02	-3.80	neuron development	biological process	GO:0048666	859	6	18204	47	APOE,WNT5A,CXCL12,MEF2C,C1QA,CSF1R
2.248e-02	-3.79	blood circulation	biological process	GO:0008015	418	4	18204	47	C3AR1,CXCL12,APOE,KCNMB1
2.254e-02	-3.79	Synthesis of Lipoxins (LX)	REACTOME pathways	R-HSA-2142700	6	1	10285	39	LTC4S
2.262e-02	-3.79	regulation of animal organ morphogenesis	biological process	GO:2000027	90	2	18204	47	WNT5A,PDGFA
2.272e-02	-3.78	human chr4p15.33	chromosome location	human chr4p15.33	12	1	26134	50	HS3ST1
2.276e-02	-3.78	MADSDOMAIN	prints domains	PR00404	5	1	5227	24	MEF2C
2.282e-02	-3.78	monocarboxylic acid binding	molecular function	GO:0033293	88	2	18094	48	PPARD,APOC1
2.283e-02	-3.78	PDGF	smart domains	SM00141	8	1	9717	28	PDGFA
2.285e-02	-3.78	spectrin	cellular component	GO:0008091	9	1	19108	49	EPB41L2
2.285e-02	-3.78	regulation of cytokine production	biological process	GO:0001817	863	6	18204	47	C3AR1,HAVCR2,WNT5A,CSF1R,TREM2,AXL
2.290e-02	-3.78	GNRHR (gonadotropin releasing hormone receptor)	protein interactions	2798	9	1	19454	50	RGS10
2.290e-02	-3.78	Prmt5 (protein arginine N-methyltransferase 5)	protein interactions	27374	9	1	19454	50	WDR77
2.290e-02	-3.78	Hnrnph1 (heterogeneous nuclear ribonucleoprotein H1)	protein interactions	59013	9	1	19454	50	WDR77
2.290e-02	-3.78	ALPK1 (alpha kinase 1)	protein interactions	80216	9	1	19454	50	ALPK1
2.290e-02	-3.78	IFI27 (interferon alpha inducible protein 27)	protein interactions	3429	9	1	19454	50	APOC2
2.290e-02	-3.78	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	50	APOE
2.290e-02	-3.78	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	50	APOE
2.290e-02	-3.78	RDH8 (retinol dehydrogenase 8)	protein interactions	50700	9	1	19454	50	PDGFA
2.293e-02	-3.78	cytoplasmic vesicle	cellular component	GO:0031410	2521	12	19108	49	TSPAN15,RNASET2,C3AR1,APOE,PDGFA,CD68,WNT5A,ABCB4,APOC2,HAVCR2,OSBPL1A,ITM2B
2.295e-02	-3.77	regulation of endothelial cell migration	biological process	GO:0010594	236	3	18204	47	WNT5A,MEF2C,APOE
2.300e-02	-3.77	foam cell differentiation	biological process	GO:0090077	9	1	18204	47	WNT5A
2.300e-02	-3.77	regulation of hair follicle maturation	biological process	GO:0048819	9	1	18204	47	WNT5A
2.300e-02	-3.77	negative regulation of axon extension involved in axon guidance	biological process	GO:0048843	9	1	18204	47	WNT5A
2.300e-02	-3.77	sterol catabolic process	biological process	GO:0016127	9	1	18204	47	APOE
2.300e-02	-3.77	negative regulation of cellular extravasation	biological process	GO:0002692	9	1	18204	47	CXCL12
2.300e-02	-3.77	regulation of complement activation, classical pathway	biological process	GO:0030450	9	1	18204	47	TREM2
2.300e-02	-3.77	regulation of protein localization to cell cortex	biological process	GO:1904776	9	1	18204	47	EPB41L2
2.300e-02	-3.77	epithelial cell proliferation involved in prostate gland development	biological process	GO:0060767	9	1	18204	47	WDR77
2.300e-02	-3.77	positive regulation of antigen processing and presentation	biological process	GO:0002579	9	1	18204	47	TREM2
2.300e-02	-3.77	positive regulation of protein kinase C signaling	biological process	GO:0090037	9	1	18204	47	WNT5A
2.300e-02	-3.77	negative regulation of antigen processing and presentation	biological process	GO:0002578	9	1	18204	47	CD68
2.300e-02	-3.77	regulation of branching involved in salivary gland morphogenesis	biological process	GO:0060693	9	1	18204	47	PDGFA
2.300e-02	-3.77	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	47	APOE
2.300e-02	-3.77	positive regulation of myeloid cell apoptotic process	biological process	GO:0033034	9	1	18204	47	MEF2C
2.300e-02	-3.77	toll-like receptor 9 signaling pathway	biological process	GO:0034162	9	1	18204	47	HAVCR2
2.300e-02	-3.77	mesenchymal-epithelial cell signaling	biological process	GO:0060638	9	1	18204	47	WNT5A
2.300e-02	-3.77	glomerulus morphogenesis	biological process	GO:0072102	9	1	18204	47	MEF2C
2.300e-02	-3.77	positive regulation of hematopoietic stem cell proliferation	biological process	GO:1902035	9	1	18204	47	WNT5A
2.300e-02	-3.77	respiratory burst involved in defense response	biological process	GO:0002679	9	1	18204	47	TREM2
2.300e-02	-3.77	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	biological process	GO:0002858	9	1	18204	47	HAVCR2
2.309e-02	-3.77	regulation of fibroblast proliferation	biological process	GO:0048145	91	2	18204	47	WNT5A,PDGFA
2.309e-02	-3.77	cellular oxidant detoxification	biological process	GO:0098869	91	2	18204	47	LTC4S,APOE
2.309e-02	-3.77	regulation of smooth muscle cell migration	biological process	GO:0014910	91	2	18204	47	MEF2C,PDGFA
2.320e-02	-3.76	epithelial cell differentiation	biological process	GO:0030855	634	5	18204	47	WDR77,COL18A1,DHRS9,WNT5A,MEF2C
2.320e-02	-3.76	anatomical structure maturation	biological process	GO:0071695	237	3	18204	47	WDR77,AXL,C1QA
2.332e-02	-3.76	intracellular vesicle	cellular component	GO:0097708	2527	12	19108	49	C3AR1,TSPAN15,RNASET2,CD68,PDGFA,APOE,WNT5A,APOC2,ABCB4,HAVCR2,ITM2B,OSBPL1A
2.339e-02	-3.76	COL18A1 (collagen type XVIII alpha 1 chain)	protein interactions	80781	92	2	19454	50	C1QB,C1QC
2.348e-02	-3.75	RANBP9 (RAN binding protein 9)	protein interactions	10048	425	4	19454	50	AXL,PPARD,SPP1,ADAP2
2.353e-02	-3.75	haematopoietic_and_lymphoid_tissue-other-normal	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-other-normal	8	1	16828	50	CSF1R
2.353e-02	-3.75	GPCRs, Class A Rhodopsin-like	WikiPathways	WP455	259	4	5310	23	ADORA3,P2RY13,C3AR1,GPR34
2.357e-02	-3.75	cellular response to chemokine	biological process	GO:1990869	92	2	18204	47	TREM2,CXCL12
2.357e-02	-3.75	response to chemokine	biological process	GO:1990868	92	2	18204	47	CXCL12,TREM2
2.363e-02	-3.75	androstan-3-alpha,17-beta-diol dehydrogenase activity	molecular function	GO:0047044	9	1	18094	48	DHRS9
2.372e-02	-3.74	regulation of hemopoiesis	biological process	GO:1903706	425	4	18204	47	TREM2,MEF2C,AXL,C1QC
2.376e-02	-3.74	clathrin-coated endocytic vesicle	cellular component	GO:0045334	93	2	19108	49	APOE,WNT5A
2.376e-02	-3.74	Schaffer collateral - CA1 synapse	cellular component	GO:0098685	93	2	19108	49	ADORA3,WNT5A
2.380e-02	-3.74	alcohol binding	molecular function	GO:0043178	90	2	18094	48	ADAP2,OSBPL1A
2.387e-02	-3.74	MAIP1 (matrix AAA peptidase interacting protein 1)	protein interactions	79568	93	2	19454	50	APOC2,APOC1
2.387e-02	-3.74	ADAM10 (ADAM metallopeptidase domain 10)	protein interactions	102	93	2	19454	50	AXL,TSPAN15
2.404e-02	-3.73	RECEPTOR_TYR_KIN_III	prosite domains	PS00240	8	1	12186	37	CSF1R
2.404e-02	-3.73	PDGF/VEGF_dom	interpro domains	IPR000072	9	1	18521	50	PDGFA
2.404e-02	-3.73	BRICHOS_dom	interpro domains	IPR007084	9	1	18521	50	ITM2B
2.405e-02	-3.73	fatty acid transport	biological process	GO:0015908	93	2	18204	47	PPARD,APOE
2.405e-02	-3.73	positive regulation of cellular component organization	biological process	GO:0051130	1122	7	18204	47	TREM2,WNT5A,APOE,AXL,ABCB4,CXCL12,APOC2
2.417e-02	-3.72	positive regulation of developmental process	biological process	GO:0051094	1385	8	18204	47	MEF2C,AXL,CXCL12,WNT5A,TREM2,PPARD,C3AR1,APOE
2.427e-02	-3.72	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	47	CSF1R,AXL,PDGFA,WNT5A
2.427e-02	-3.72	regulation of inflammatory response	biological process	GO:0050727	428	4	18204	47	TREM2,WNT5A,APOE,PPARD
2.435e-02	-3.72	NDUFB3 (NADH:ubiquinone oxidoreductase subunit B3)	protein interactions	4709	94	2	19454	50	GPR34,C3AR1
2.438e-02	-3.71	postsynapse	cellular component	GO:0098794	646	5	19108	49	C1QC,C1QB,MEF2C,WNT5A,C1QA
2.438e-02	-3.71	BAG6 (BAG cochaperone 6)	protein interactions	7917	430	4	19454	50	HAVCR2,AXL,SPP1,C1QA
2.453e-02	-3.71	positive regulation of neuron differentiation	biological process	GO:0045666	94	2	18204	47	MEF2C,CXCL12
2.456e-02	-3.71	TUBB3 (tubulin beta 3 class III)	protein interactions	10381	431	4	19454	50	PPARD,C1QA,WDR77,EPB41L2
2.500e-02	-3.69	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	3	7161	28	MEF2C,ADORA3,KCNMB1
2.500e-02	-3.69	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	3	7161	28	MEF2C,KCNMB1,ADORA3
2.501e-02	-3.69	BRICHOS	pfam domains	PF04089	9	1	17795	50	ITM2B
2.501e-02	-3.69	PDGF	pfam domains	PF00341	9	1	17795	50	PDGFA
2.502e-02	-3.69	regulation of neuron apoptotic process	biological process	GO:0043523	244	3	18204	47	TREM2,MEF2C,AXL
2.518e-02	-3.68	cytokine activity	molecular function	GO:0005125	238	3	18094	48	SPP1,CXCL12,WNT5A
2.523e-02	-3.68	IG	smart domains	SM00409	394	4	9717	28	AXL,HAVCR2,SIGLEC8,CSF1R
2.536e-02	-3.67	tetraspanin-enriched microdomain	cellular component	GO:0097197	10	1	19108	49	TSPAN15
2.541e-02	-3.67	ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2)	protein interactions	8128	10	1	19454	50	HS3ST1
2.541e-02	-3.67	C1RL (complement C1r subcomponent like)	protein interactions	51279	10	1	19454	50	SPP1
2.541e-02	-3.67	TMEM204 (transmembrane protein 204)	protein interactions	79652	10	1	19454	50	AXL
2.541e-02	-3.67	TNP1 (transition protein 1)	protein interactions	7141	10	1	19454	50	PPARD
2.541e-02	-3.67	C1S (complement C1s)	protein interactions	716	10	1	19454	50	C1QA
2.541e-02	-3.67	HMCN1 (hemicentin 1)	protein interactions	83872	10	1	19454	50	WDR77
2.541e-02	-3.67	DSCR4 (Down syndrome critical region 4)	protein interactions	10281	10	1	19454	50	APOC2
2.551e-02	-3.67	negative regulation of developmental growth	biological process	GO:0048640	96	2	18204	47	WNT5A,SPP1
2.553e-02	-3.67	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	47	APOE
2.553e-02	-3.67	germinal center formation	biological process	GO:0002467	10	1	18204	47	MEF2C
2.553e-02	-3.67	prostate glandular acinus development	biological process	GO:0060525	10	1	18204	47	WDR77
2.553e-02	-3.67	regulation of natural killer cell mediated immune response to tumor cell	biological process	GO:0002855	10	1	18204	47	HAVCR2
2.553e-02	-3.67	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	47	APOE
2.553e-02	-3.67	regulation of apoptotic cell clearance	biological process	GO:2000425	10	1	18204	47	TREM2
2.553e-02	-3.67	regulation of phosphatidylcholine metabolic process	biological process	GO:0150172	10	1	18204	47	APOC1
2.553e-02	-3.67	positive regulation of microglial cell activation	biological process	GO:1903980	10	1	18204	47	TREM2
2.553e-02	-3.67	planar cell polarity pathway involved in neural tube closure	biological process	GO:0090179	10	1	18204	47	WNT5A
2.553e-02	-3.67	cellular response to lipoteichoic acid	biological process	GO:0071223	10	1	18204	47	TREM2
2.553e-02	-3.67	regulation of resting membrane potential	biological process	GO:0060075	10	1	18204	47	TREM2
2.553e-02	-3.67	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	47	APOE
2.553e-02	-3.67	negative regulation of natural killer cell activation	biological process	GO:0032815	10	1	18204	47	HAVCR2
2.553e-02	-3.67	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	47	APOE
2.553e-02	-3.67	paraxial mesoderm morphogenesis	biological process	GO:0048340	10	1	18204	47	WNT5A
2.553e-02	-3.67	response to folic acid	biological process	GO:0051593	10	1	18204	47	FOLR2
2.553e-02	-3.67	integrin activation	biological process	GO:0033622	10	1	18204	47	CXCL12
2.553e-02	-3.67	positive regulation of ATP biosynthetic process	biological process	GO:2001171	10	1	18204	47	TREM2
2.553e-02	-3.67	development of secondary sexual characteristics	biological process	GO:0045136	10	1	18204	47	WNT5A
2.553e-02	-3.67	cellular response to testosterone stimulus	biological process	GO:0071394	10	1	18204	47	SPP1
2.553e-02	-3.67	negative regulation of glial cell apoptotic process	biological process	GO:0034351	10	1	18204	47	TREM2
2.553e-02	-3.67	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	47	APOE
2.553e-02	-3.67	regulation of postsynaptic cytosolic calcium ion concentration	biological process	GO:0099566	10	1	18204	47	WNT5A
2.553e-02	-3.67	folic acid transport	biological process	GO:0015884	10	1	18204	47	FOLR2
2.553e-02	-3.67	endothelial cell morphogenesis	biological process	GO:0001886	10	1	18204	47	COL18A1
2.553e-02	-3.67	cellular response to parathyroid hormone stimulus	biological process	GO:0071374	10	1	18204	47	MEF2C
2.553e-02	-3.67	response to lipoteichoic acid	biological process	GO:0070391	10	1	18204	47	TREM2
2.553e-02	-3.67	regulation of epithelial cell proliferation involved in prostate gland development	biological process	GO:0060768	10	1	18204	47	WDR77
2.565e-02	-3.66	BRICHOS	smart domains	SM01039	9	1	9717	28	ITM2B
2.565e-02	-3.66	ORANGE	smart domains	SM00511	9	1	9717	28	BHLHE41
2.579e-02	-3.66	response to endogenous stimulus	biological process	GO:0009719	1402	8	18204	47	WNT5A,TREM2,PPARD,CD68,MEF2C,SPP1,FOLR2,CXCL12
2.581e-02	-3.66	GSDMA (gasdermin A)	protein interactions	284110	97	2	19454	50	APOC2,APOC1
2.581e-02	-3.66	ATP13A2 (ATPase cation transporting 13A2)	protein interactions	23400	97	2	19454	50	HAVCR2,TSPAN15
2.600e-02	-3.65	leukocyte homeostasis	biological process	GO:0001776	97	2	18204	47	AXL,MEF2C
2.600e-02	-3.65	acylglycerol metabolic process	biological process	GO:0006639	97	2	18204	47	APOE,APOC1
2.622e-02	-3.64	minor groove of adenine-thymine-rich DNA binding	molecular function	GO:0003680	10	1	18094	48	MEF2C
2.646e-02	-3.63	human chr7q21.12	chromosome location	human chr7q21.12	14	1	26134	50	ABCB4
2.650e-02	-3.63	regulation of striated muscle cell differentiation	biological process	GO:0051153	98	2	18204	47	MEF2C,BHLHE41
2.650e-02	-3.63	neutral lipid metabolic process	biological process	GO:0006638	98	2	18204	47	APOC1,APOE
2.671e-02	-3.62	organic cyclic compound catabolic process	biological process	GO:1901361	441	4	18204	47	RNASET2,RNASEH1,APOE,SPP1
2.680e-02	-3.62	TLCD4 (TLC domain containing 4)	protein interactions	148534	99	2	19454	50	C3AR1,TSPAN15
2.701e-02	-3.61	axis specification	biological process	GO:0009798	99	2	18204	47	WNT5A,WDR77
2.701e-02	-3.61	BRICHOS	prosite domains	PS50869	9	1	12186	37	ITM2B
2.701e-02	-3.61	PDGF_2	prosite domains	PS50278	9	1	12186	37	PDGFA
2.704e-02	-3.61	-	gene3d domains	6.10.250.980	9	1	14470	44	BHLHE41
2.710e-02	-3.61	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	47	WNT5A,CXCL12,SPP1,APOE
2.710e-02	-3.61	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	4	18204	47	WNT5A,CSF1R,MEF2C,CXCL12
2.718e-02	-3.61	GPCR ligand binding	REACTOME pathways	R-HSA-500792	453	5	10285	39	P2RY13,CXCL12,C3AR1,WNT5A,ADORA3
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	AXL,CSF1R
2.727e-02	-3.60	Integrin cell surface interactions	REACTOME pathways	R-HSA-216083	68	2	10285	39	SPP1,COL18A1
2.731e-02	-3.60	SYNE4 (spectrin repeat containing nuclear envelope family member 4)	protein interactions	163183	100	2	19454	50	ITM2B,TSPAN15
2.779e-02	-3.58	tube development	biological process	GO:0035295	903	6	18204	47	APOE,CSF1R,MEF2C,PDGFA,WNT5A,COL18A1
2.781e-02	-3.58	FAM241A (family with sequence similarity 241 member A)	protein interactions	132720	101	2	19454	50	C3AR1,TSPAN15
2.781e-02	-3.58	TMEM11 (transmembrane protein 11)	protein interactions	8834	101	2	19454	50	RNASEH1,ADORA3
2.786e-02	-3.58	Metabolism of vitamins and cofactors	REACTOME pathways	R-HSA-196854	174	3	10285	39	APOE,APOC2,FOLR2
2.792e-02	-3.58	NUDT2 (nudix hydrolase 2)	protein interactions	318	11	1	19454	50	ANKRD22
2.792e-02	-3.58	TMEM168 (transmembrane protein 168)	protein interactions	64418	11	1	19454	50	SPP1
2.792e-02	-3.58	MEF2B (myocyte enhancer factor 2B)	protein interactions	100271849	11	1	19454	50	MEF2C
2.792e-02	-3.58	FAM200A (family with sequence similarity 200 member A)	protein interactions	221786	11	1	19454	50	RGL3
2.792e-02	-3.58	ALOX5AP (arachidonate 5-lipoxygenase activating protein)	protein interactions	241	11	1	19454	50	LTC4S
2.792e-02	-3.58	C2orf50 (chromosome 2 open reading frame 50)	protein interactions	130813	11	1	19454	50	SPP1
2.794e-02	-3.58	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	47	TREM2,WNT5A,APOE,CXCL12,SPP1
2.799e-02	-3.58	generation of neurons	biological process	GO:0048699	1158	7	18204	47	WNT5A,APOE,MEF2C,C1QA,AXL,CSF1R,CXCL12
2.802e-02	-3.57	negative regulation of endothelial cell migration	biological process	GO:0010596	101	2	18204	47	APOE,MEF2C
2.802e-02	-3.57	cholesterol homeostasis	biological process	GO:0042632	101	2	18204	47	APOE,APOC2
2.802e-02	-3.57	regulation of potassium ion transport	biological process	GO:0043266	101	2	18204	47	TREM2,KCNMB1
2.804e-02	-3.57	neuron projection extension involved in neuron projection guidance	biological process	GO:1902284	11	1	18204	47	WNT5A
2.804e-02	-3.57	thymocyte apoptotic process	biological process	GO:0070242	11	1	18204	47	WNT5A
2.804e-02	-3.57	positive regulation of voltage-gated potassium channel activity	biological process	GO:1903818	11	1	18204	47	TREM2
2.804e-02	-3.57	positive regulation of cardiac muscle cell differentiation	biological process	GO:2000727	11	1	18204	47	MEF2C
2.804e-02	-3.57	primitive streak formation	biological process	GO:0090009	11	1	18204	47	WNT5A
2.804e-02	-3.57	regulation of macrophage apoptotic process	biological process	GO:2000109	11	1	18204	47	MEF2C
2.804e-02	-3.57	negative regulation of collateral sprouting	biological process	GO:0048671	11	1	18204	47	SPP1
2.804e-02	-3.57	embryonic camera-type eye formation	biological process	GO:0060900	11	1	18204	47	WNT5A
2.804e-02	-3.57	regulation of dendritic cell antigen processing and presentation	biological process	GO:0002604	11	1	18204	47	CD68
2.804e-02	-3.57	positive regulation of steroid hormone secretion	biological process	GO:2000833	11	1	18204	47	SPP1
2.804e-02	-3.57	negative regulation of synapse organization	biological process	GO:1905809	11	1	18204	47	WNT5A
2.804e-02	-3.57	regulation of establishment of planar polarity involved in neural tube closure	biological process	GO:0090178	11	1	18204	47	WNT5A
2.804e-02	-3.57	positive regulation of lipoprotein particle clearance	biological process	GO:0010986	11	1	18204	47	TREM2
2.804e-02	-3.57	regulation of high-density lipoprotein particle clearance	biological process	GO:0010982	11	1	18204	47	TREM2
2.804e-02	-3.57	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	47	APOE
2.804e-02	-3.57	cardiac chamber formation	biological process	GO:0003207	11	1	18204	47	MEF2C
2.804e-02	-3.57	dendritic spine maintenance	biological process	GO:0097062	11	1	18204	47	TREM2
2.804e-02	-3.57	positive regulation of cell-cell adhesion mediated by cadherin	biological process	GO:2000049	11	1	18204	47	WNT5A
2.804e-02	-3.57	epithelial cell differentiation involved in prostate gland development	biological process	GO:0060742	11	1	18204	47	WDR77
2.804e-02	-3.57	axon extension involved in axon guidance	biological process	GO:0048846	11	1	18204	47	WNT5A
2.830e-02	-3.56	positive regulation of growth	biological process	GO:0045927	256	3	18204	47	MEF2C,CXCL12,PPARD
2.830e-02	-3.56	positive regulation of protein kinase activity	biological process	GO:0045860	256	3	18204	47	CSF1R,PDGFA,WNT5A
2.854e-02	-3.56	sterol homeostasis	biological process	GO:0055092	102	2	18204	47	APOC2,APOE
2.855e-02	-3.56	system development	biological process	GO:0048731	3533	15	18204	47	ITM2B,WNT5A,PDGFA,TREM2,PPARD,APOE,WDR77,AXL,CSF1R,CXCL12,COL18A1,HAVCR2,ADAP2,MEF2C,C1QA
2.860e-02	-3.55	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	3	19454	50	PDGFA,EPB41L2,AXL
2.861e-02	-3.55	regulation of signaling	biological process	GO:0023051	3534	15	18204	47	HAVCR2,ALPK1,ADORA3,MEF2C,PDGFA,WNT5A,TREM2,PPARD,APOE,TSPAN15,AXL,CSF1R,RGS10,SPP1,CXCL12
2.880e-02	-3.55	complement receptor activity	molecular function	GO:0004875	11	1	18094	48	C3AR1
2.880e-02	-3.55	platelet-derived growth factor binding	molecular function	GO:0048407	11	1	18094	48	PDGFA
2.880e-02	-3.55	testosterone dehydrogenase [NAD(P)] activity	molecular function	GO:0030283	11	1	18094	48	DHRS9
2.884e-02	-3.55	KLRG2 (killer cell lectin like receptor G2)	protein interactions	346689	103	2	19454	50	WNT5A,HS3ST1
2.884e-02	-3.55	CERS6 (ceramide synthase 6)	protein interactions	253782	103	2	19454	50	C3AR1,TSPAN15
2.884e-02	-3.55	ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)	protein interactions	25921	103	2	19454	50	AXL,HAVCR2
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	HAVCR2,SIGLEC8,AXL,CSF1R
2.908e-02	-3.54	regulation of cell communication	biological process	GO:0010646	3541	15	18204	47	ADORA3,MEF2C,ALPK1,HAVCR2,TSPAN15,CSF1R,AXL,CXCL12,SPP1,RGS10,WNT5A,PDGFA,TREM2,PPARD,APOE
2.926e-02	-3.53	negative regulation of apoptotic process	biological process	GO:0043066	914	6	18204	47	WNT5A,TREM2,CXCL12,CSF1R,MEF2C,AXL
2.926e-02	-3.53	chemical homeostasis	biological process	GO:0048878	914	6	18204	47	APOC2,CXCL12,APOE,WNT5A,TREM2,ABCB4
2.930e-02	-3.53	embryonic organ development	biological process	GO:0048568	454	4	18204	47	COL18A1,PDGFA,WNT5A,MEF2C
2.931e-02	-3.53	NST/OST	interpro domains	IPR037359	11	1	18521	50	HS3ST1
2.931e-02	-3.53	Type_1_exporter	interpro domains	IPR039421	11	1	18521	50	ABCB4
2.936e-02	-3.53	KLHL12 (kelch like family member 12)	protein interactions	59349	104	2	19454	50	KLHL5,RGL3
2.946e-02	-3.52	LGR4 (leucine rich repeat containing G protein-coupled receptor 4)	protein interactions	55366	261	3	19454	50	HS3ST1,HAVCR2,TSPAN15
2.954e-02	-3.52	Circadian Clock	REACTOME pathways	R-HSA-400253	71	2	10285	39	MEF2C,BHLHE41
2.958e-02	-3.52	regulation of steroid metabolic process	biological process	GO:0019218	104	2	18204	47	CH25H,APOE
2.958e-02	-3.52	epithelial cell migration	biological process	GO:0010631	104	2	18204	47	PPARD,WNT5A
2.987e-02	-3.51	Lung fibrosis	WikiPathways	WP3624	63	2	5310	23	PDGFA,SPP1
2.995e-02	-3.51	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	REACTOME pathways	R-HSA-5688890	8	1	10285	39	CSF2RA
2.995e-02	-3.51	Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	REACTOME pathways	R-HSA-5688849	8	1	10285	39	CSF2RA
3.000e-02	-3.51	-	gene3d domains	3.30.70.3490	10	1	14470	44	OSBPL1A
3.002e-02	-3.51	biological process involved in symbiotic interaction	biological process	GO:0044403	262	3	18204	47	APOE,CSF1R,AXL
3.010e-02	-3.50	gland morphogenesis	biological process	GO:0022612	105	2	18204	47	CSF1R,WNT5A
3.010e-02	-3.50	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	47	WNT5A,APOE
3.033e-02	-3.50	synaptic signaling	biological process	GO:0099536	459	4	18204	47	MEF2C,APOE,RGS10,KCNMB1
3.036e-02	-3.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	5	19454	50	DCBLD1,RGL3,ITM2B,WDR77,EPB41L2
3.042e-02	-3.49	SIRPB1 (signal regulatory protein beta 1)	protein interactions	10326	12	1	19454	50	APOC1
3.042e-02	-3.49	RSC1A1 (regulator of solute carriers 1)	protein interactions	6248	12	1	19454	50	SPP1
3.042e-02	-3.49	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	50	APOE
3.042e-02	-3.49	PORCN (porcupine O-acyltransferase)	protein interactions	64840	12	1	19454	50	APOC2
3.042e-02	-3.49	TM7SF2 (transmembrane 7 superfamily member 2)	protein interactions	7108	12	1	19454	50	TSPAN15
3.049e-02	-3.49	Hairy_orange	pfam domains	PF07527	11	1	17795	50	BHLHE41
3.056e-02	-3.49	cellular response to antibiotic	biological process	GO:0071236	12	1	18204	47	MEF2C
3.056e-02	-3.49	heparan sulfate proteoglycan biosynthetic process, enzymatic modification	biological process	GO:0015015	12	1	18204	47	HS3ST1
3.056e-02	-3.49	hormone catabolic process	biological process	GO:0042447	12	1	18204	47	SPP1
3.056e-02	-3.49	regulation of skeletal muscle satellite cell proliferation	biological process	GO:0014842	12	1	18204	47	PPARD
3.056e-02	-3.49	negative regulation of transcription by competitive promoter binding	biological process	GO:0010944	12	1	18204	47	BHLHE41
3.056e-02	-3.49	regulation of glomerular mesangial cell proliferation	biological process	GO:0072124	12	1	18204	47	PDGFA
3.056e-02	-3.49	positive regulation of hair follicle development	biological process	GO:0051798	12	1	18204	47	WNT5A
3.056e-02	-3.49	negative regulation of macrophage cytokine production	biological process	GO:0010936	12	1	18204	47	AXL
3.056e-02	-3.49	very-low-density lipoprotein particle assembly	biological process	GO:0034379	12	1	18204	47	APOC1
3.056e-02	-3.49	regulation of pinocytosis	biological process	GO:0048548	12	1	18204	47	AXL
3.056e-02	-3.49	regulation of chemokine-mediated signaling pathway	biological process	GO:0070099	12	1	18204	47	TREM2
3.056e-02	-3.49	regulation of glial cell apoptotic process	biological process	GO:0034350	12	1	18204	47	TREM2
3.056e-02	-3.49	regulation of toll-like receptor 2 signaling pathway	biological process	GO:0034135	12	1	18204	47	TREM2
3.056e-02	-3.49	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	47	APOE
3.056e-02	-3.49	midgut development	biological process	GO:0007494	12	1	18204	47	WNT5A
3.056e-02	-3.49	positive regulation of catecholamine secretion	biological process	GO:0033605	12	1	18204	47	CXCL12
3.063e-02	-3.49	pigmentation	biological process	GO:0043473	106	2	18204	47	MEF2C,APOE
3.070e-02	-3.48	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	47	SPP1,APOE,CXCL12,TREM2,WNT5A
3.116e-02	-3.47	neuron apoptotic process	biological process	GO:0051402	107	2	18204	47	USP53,AXL
3.116e-02	-3.47	columnar/cuboidal epithelial cell differentiation	biological process	GO:0002065	107	2	18204	47	WDR77,WNT5A
3.116e-02	-3.47	epithelium migration	biological process	GO:0090132	107	2	18204	47	PPARD,WNT5A
3.129e-02	-3.46	positive regulation of biological process	biological process	GO:0048518	6326	23	18204	47	ALPK1,HAVCR2,MEF2C,TREM2,FOLR2,EPB41L2,APOC2,ABCB4,CSF1R,C3AR1,KCNMB1,C1QB,C1QA,APOE,WDR77,C1QC,PPARD,WNT5A,PDGFA,CSF2RA,CXCL12,SPP1,AXL
3.137e-02	-3.46	cell morphogenesis	biological process	GO:0000902	687	5	18204	47	CXCL12,COL18A1,WNT5A,MEF2C,CSF1R
3.138e-02	-3.46	phospholipase inhibitor activity	molecular function	GO:0004859	12	1	18094	48	APOC1
3.147e-02	-3.46	CAMKV (CaM kinase like vesicle associated)	protein interactions	79012	108	2	19454	50	COL18A1,EPB41L2
3.150e-02	-3.46	regulation of protein serine/threonine kinase activity	biological process	GO:0071900	267	3	18204	47	APOE,WNT5A,PDGFA
3.154e-02	-3.46	hemopoiesis	biological process	GO:0030097	688	5	18204	47	WNT5A,MEF2C,AXL,TREM2,CSF1R
3.164e-02	-3.45	Endochondral Ossification	WikiPathways	WP474	65	2	5310	23	MEF2C,SPP1
3.170e-02	-3.45	tissue remodeling	biological process	GO:0048771	108	2	18204	47	AXL,MEF2C
3.182e-02	-3.45	Transcriptional misregulation in cancer	KEGG pathways	hsa05202	179	3	7161	28	CSF1R,PDGFA,MEF2C
3.182e-02	-3.45	Transcriptional misregulation in cancer	KEGG pathways	ko05202	179	3	7161	28	MEF2C,PDGFA,CSF1R
3.193e-02	-3.44	circulatory system development	biological process	GO:0072359	933	6	18204	47	MEF2C,PDGFA,WNT5A,ADAP2,COL18A1,APOE
3.193e-02	-3.44	Formyl_rcpt-rel	interpro domains	IPR000826	12	1	18521	50	C3AR1
3.193e-02	-3.44	OSBP_sf	interpro domains	IPR037239	12	1	18521	50	OSBPL1A
3.193e-02	-3.44	Oxysterol-bd	interpro domains	IPR000648	12	1	18521	50	OSBPL1A
3.193e-02	-3.44	Orange_dom	interpro domains	IPR003650	12	1	18521	50	BHLHE41
3.193e-02	-3.44	Oxysterol-bd_CS	interpro domains	IPR018494	12	1	18521	50	OSBPL1A
3.221e-02	-3.44	bone-calcaneus-chondrosarcoma	COSMIC cancer mutations	bone-calcaneus-chondrosarcoma	11	1	16828	50	ALPK1
3.224e-02	-3.43	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	2	18204	47	HAVCR2,WNT5A
3.224e-02	-3.43	regulation of non-canonical NF-kappaB signal transduction	biological process	GO:1901222	109	2	18204	47	TREM2,HAVCR2
3.247e-02	-3.43	regulation of protein kinase activity	biological process	GO:0045859	469	4	18204	47	APOE,WNT5A,PDGFA,CSF1R
3.249e-02	-3.43	HIF-1-alpha transcription factor network	Pathway Interaction DB	hif1_tfpathway	65	2	2226	10	CXCL12,BHLHE41
3.254e-02	-3.43	BBS1 (Bardet-Biedl syndrome 1)	protein interactions	582	110	2	19454	50	RGS10,HAVCR2
3.254e-02	-3.43	KIT (KIT proto-oncogene, receptor tyrosine kinase)	protein interactions	3815	110	2	19454	50	CSF1R,CSF2RA
3.254e-02	-3.43	SPACA1 (sperm acrosome associated 1)	protein interactions	81833	110	2	19454	50	ITM2B,TSPAN15
3.254e-02	-3.43	DKKL1 (dickkopf like acrosomal protein 1)	protein interactions	27120	110	2	19454	50	ITM2B,HS3ST1
3.271e-02	-3.42	carboxylic acid biosynthetic process	biological process	GO:0046394	271	3	18204	47	OSBPL1A,LTC4S,DHRS9
3.278e-02	-3.42	positive regulation of endothelial cell proliferation	biological process	GO:0001938	110	2	18204	47	CXCL12,WNT5A
3.278e-02	-3.42	regulation of interleukin-1 beta production	biological process	GO:0032651	110	2	18204	47	WNT5A,TREM2
3.280e-02	-3.42	Class A/1 (Rhodopsin-like receptors)	REACTOME pathways	R-HSA-373076	322	4	10285	39	P2RY13,CXCL12,C3AR1,ADORA3
3.284e-02	-3.42	methylosome	cellular component	GO:0034709	13	1	19108	49	WDR77
3.291e-02	-3.41	Nfya (nuclear transcription factor-Y alpha)	protein interactions	18044	13	1	19454	50	OSBPL1A
3.291e-02	-3.41	TECPR1 (tectonin beta-propeller repeat containing 1)	protein interactions	25851	13	1	19454	50	COL18A1
3.291e-02	-3.41	KCNQ4 (potassium voltage-gated channel subfamily Q member 4)	protein interactions	9132	13	1	19454	50	CSF1R
3.291e-02	-3.41	TEX44 (testis expressed 44)	protein interactions	165100	13	1	19454	50	APOC1
3.291e-02	-3.41	CCL20 (C-C motif chemokine ligand 20)	protein interactions	6364	13	1	19454	50	CXCL12
3.291e-02	-3.41	CSF2RA (colony stimulating factor 2 receptor subunit alpha)	protein interactions	1438	13	1	19454	50	CSF2RA
3.291e-02	-3.41	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	50	APOE
3.291e-02	-3.41	PRKG2 (protein kinase cGMP-dependent 2)	protein interactions	5593	13	1	19454	50	WDR77
3.292e-02	-3.41	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	37	AXL,CSF1R
3.306e-02	-3.41	response to peptidoglycan	biological process	GO:0032494	13	1	18204	47	TREM2
3.306e-02	-3.41	detection of calcium ion	biological process	GO:0005513	13	1	18204	47	KCNMB1
3.306e-02	-3.41	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	47	APOE
3.306e-02	-3.41	response to water	biological process	GO:0009415	13	1	18204	47	COL18A1
3.306e-02	-3.41	positive regulation of T cell apoptotic process	biological process	GO:0070234	13	1	18204	47	WNT5A
3.306e-02	-3.41	positive regulation of phagocytosis, engulfment	biological process	GO:0060100	13	1	18204	47	TREM2
3.306e-02	-3.41	regulation of triglyceride catabolic process	biological process	GO:0010896	13	1	18204	47	APOC2
3.306e-02	-3.41	olfactory bulb interneuron differentiation	biological process	GO:0021889	13	1	18204	47	WNT5A
3.306e-02	-3.41	negative regulation of leukocyte adhesion to vascular endothelial cell	biological process	GO:1904995	13	1	18204	47	CXCL12
3.306e-02	-3.41	forebrain morphogenesis	biological process	GO:0048853	13	1	18204	47	WNT5A
3.306e-02	-3.41	regulation of natural killer cell differentiation	biological process	GO:0032823	13	1	18204	47	AXL
3.306e-02	-3.41	positive regulation of glial cell migration	biological process	GO:1903977	13	1	18204	47	TREM2
3.306e-02	-3.41	progesterone metabolic process	biological process	GO:0042448	13	1	18204	47	DHRS9
3.306e-02	-3.41	regulation of thymocyte apoptotic process	biological process	GO:0070243	13	1	18204	47	WNT5A
3.306e-02	-3.41	response to parathyroid hormone	biological process	GO:0071107	13	1	18204	47	MEF2C
3.306e-02	-3.41	detection of molecule of bacterial origin	biological process	GO:0032490	13	1	18204	47	TREM2
3.306e-02	-3.41	regulation of norepinephrine secretion	biological process	GO:0014061	13	1	18204	47	ADORA3
3.306e-02	-3.41	midbrain dopaminergic neuron differentiation	biological process	GO:1904948	13	1	18204	47	WNT5A
3.306e-02	-3.41	convergent extension	biological process	GO:0060026	13	1	18204	47	WNT5A
3.306e-02	-3.41	positive regulation of membrane invagination	biological process	GO:1905155	13	1	18204	47	TREM2
3.309e-02	-3.41	KIAA2013 (KIAA2013)	protein interactions	90231	111	2	19454	50	TSPAN15,GPR34
3.309e-02	-3.41	TMEM120B (transmembrane protein 120B)	protein interactions	144404	111	2	19454	50	C3AR1,TSPAN15
3.313e-02	-3.41	cell projection organization	biological process	GO:0030030	1200	7	18204	47	APOE,ALPK1,WNT5A,PDGFA,TREM2,CXCL12,CSF1R
3.321e-02	-3.40	Oxysterol_BP	pfam domains	PF01237	12	1	17795	50	OSBPL1A
3.363e-02	-3.39	Ca2+ activated K+ channels	REACTOME pathways	R-HSA-1296052	9	1	10285	39	KCNMB1
3.363e-02	-3.39	Synthesis of 5-eicosatetraenoic acids	REACTOME pathways	R-HSA-2142688	9	1	10285	39	LTC4S
3.363e-02	-3.39	COPS8 (COP9 signalosome subunit 8)	protein interactions	10920	112	2	19454	50	WDR77,EPB41L2
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	C3AR1,AXL
3.363e-02	-3.39	SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha)	protein interactions	6449	275	3	19454	50	C1QA,SPP1,AXL
3.364e-02	-3.39	organic acid biosynthetic process	biological process	GO:0016053	274	3	18204	47	DHRS9,LTC4S,OSBPL1A
3.364e-02	-3.39	tissue development	biological process	GO:0009888	1757	9	18204	47	PPARD,WDR77,PDGFA,WNT5A,DHRS9,COL18A1,SPP1,CSF1R,MEF2C
3.384e-02	-3.39	negative regulation of programmed cell death	biological process	GO:0043069	946	6	18204	47	WNT5A,TREM2,AXL,MEF2C,CSF1R,CXCL12
3.388e-02	-3.38	mononuclear cell migration	biological process	GO:0071674	112	2	18204	47	FOLR2,CH25H
3.388e-02	-3.38	female sex differentiation	biological process	GO:0046660	112	2	18204	47	AXL,WNT5A
3.394e-02	-3.38	HMOX2 (heme oxygenase 2)	protein interactions	3163	276	3	19454	50	C3AR1,TSPAN15,APOE
3.395e-02	-3.38	gliogenesis	biological process	GO:0042063	275	3	18204	47	C1QA,CSF1R,TREM2
3.395e-02	-3.38	myosin heavy chain binding	molecular function	GO:0032036	13	1	18094	48	AXL
3.395e-02	-3.38	folic acid binding	molecular function	GO:0005542	13	1	18094	48	FOLR2
3.395e-02	-3.38	calcium-activated potassium channel activity	molecular function	GO:0015269	13	1	18094	48	KCNMB1
3.395e-02	-3.38	high-density lipoprotein particle binding	molecular function	GO:0008035	13	1	18094	48	TREM2
3.426e-02	-3.37	telencephalon development	biological process	GO:0021537	276	3	18204	47	CXCL12,WNT5A,CSF1R
3.426e-02	-3.37	learning or memory	biological process	GO:0007611	276	3	18204	47	TREM2,MEF2C,APOE
3.444e-02	-3.37	tissue migration	biological process	GO:0090130	113	2	18204	47	PPARD,WNT5A
3.444e-02	-3.37	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	2	18204	47	WNT5A,HAVCR2
3.454e-02	-3.37	CD225/Dispanin_fam	interpro domains	IPR007593	13	1	18521	50	IFITM10
3.454e-02	-3.37	FA	interpro domains	IPR014847	13	1	18521	50	EPB41L2
3.457e-02	-3.36	BASP1 (brain abundant membrane attached signal protein 1)	protein interactions	10409	278	3	19454	50	EPB41L2,WDR77,AXL
3.474e-02	-3.36	COL1A1 (collagen type I alpha 1 chain)	protein interactions	1277	114	2	19454	50	COL18A1,PDGFA
3.500e-02	-3.35	steroid biosynthetic process	biological process	GO:0006694	114	2	18204	47	CH25H,OSBPL1A
3.509e-02	-3.35	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	12	1	16828	50	CSF1R
3.530e-02	-3.34	PPARD (peroxisome proliferator activated receptor delta)	protein interactions	5467	115	2	19454	50	PPARD,RGL3
3.530e-02	-3.34	CNTNAP3 (contactin associated protein family member 3)	protein interactions	79937	115	2	19454	50	C1QB,C1QA
3.530e-02	-3.34	NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5)	protein interactions	4711	115	2	19454	50	C3AR1,GPR34
3.539e-02	-3.34	HRAS (HRas proto-oncogene, GTPase)	protein interactions	3265	712	5	19454	50	WDR77,ITM2B,USP53,EPB41L2,DCBLD1
3.540e-02	-3.34	CCL25 (C-C motif chemokine ligand 25)	protein interactions	6370	14	1	19454	50	CXCL12
3.540e-02	-3.34	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	50	APOE
3.540e-02	-3.34	PLA2G12A (phospholipase A2 group XIIA)	protein interactions	81579	14	1	19454	50	MEF2C
3.540e-02	-3.34	CROCCP2 (CROCC pseudogene 2)	protein interactions	84809	14	1	19454	50	APOC2
3.540e-02	-3.34	FFAR3 (free fatty acid receptor 3)	protein interactions	2865	14	1	19454	50	LTC4S
3.540e-02	-3.34	C9 (complement C9)	protein interactions	735	14	1	19454	50	APOE
3.540e-02	-3.34	BAALC (BAALC binder of MAP3K1 and KLF4)	protein interactions	79870	14	1	19454	50	OSBPL1A
3.540e-02	-3.34	Pten (phosphatase and tensin homolog)	protein interactions	19211	14	1	19454	50	PDGFA
3.540e-02	-3.34	CES3 (carboxylesterase 3)	protein interactions	23491	14	1	19454	50	C1QA
3.540e-02	-3.34	ADAP2 (ArfGAP with dual PH domains 2)	protein interactions	55803	14	1	19454	50	ADAP2
3.540e-02	-3.34	BORCS8-MEF2B (BORCS8-MEF2B readthrough)	protein interactions	4207	14	1	19454	50	MEF2C
3.551e-02	-3.34	EPHA7 (EPH receptor A7)	protein interactions	2045	281	3	19454	50	COL18A1,WNT5A,CSF1R
3.556e-02	-3.34	positive regulation of T cell chemotaxis	biological process	GO:0010820	14	1	18204	47	WNT5A
3.556e-02	-3.34	mammary gland epithelial cell proliferation	biological process	GO:0033598	14	1	18204	47	WNT5A
3.556e-02	-3.34	positive regulation of myoblast proliferation	biological process	GO:2000288	14	1	18204	47	PPARD
3.556e-02	-3.34	positive regulation of purine nucleotide biosynthetic process	biological process	GO:1900373	14	1	18204	47	TREM2
3.556e-02	-3.34	neuron remodeling	biological process	GO:0016322	14	1	18204	47	C1QA
3.556e-02	-3.34	complement receptor mediated signaling pathway	biological process	GO:0002430	14	1	18204	47	C3AR1
3.556e-02	-3.34	cellular response to ethanol	biological process	GO:0071361	14	1	18204	47	KCNMB1
3.556e-02	-3.34	toll-like receptor 3 signaling pathway	biological process	GO:0034138	14	1	18204	47	HAVCR2
3.556e-02	-3.34	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	47	APOE
3.556e-02	-3.34	positive regulation of defense response to bacterium	biological process	GO:1900426	14	1	18204	47	HAVCR2
3.556e-02	-3.34	regulation of establishment of planar polarity	biological process	GO:0090175	14	1	18204	47	WNT5A
3.556e-02	-3.34	ventricular cardiac muscle cell differentiation	biological process	GO:0055012	14	1	18204	47	MEF2C
3.556e-02	-3.34	positive regulation of nucleotide biosynthetic process	biological process	GO:0030810	14	1	18204	47	TREM2
3.556e-02	-3.34	terpenoid biosynthetic process	biological process	GO:0016114	14	1	18204	47	DHRS9
3.556e-02	-3.34	positive regulation of phospholipid metabolic process	biological process	GO:1903727	14	1	18204	47	APOC2
3.556e-02	-3.34	induction of positive chemotaxis	biological process	GO:0050930	14	1	18204	47	CXCL12
3.583e-02	-3.33	multicellular organismal reproductive process	biological process	GO:0048609	959	6	18204	47	PPARD,HAVCR2,WDR77,FOLR2,SPP1,AXL
3.585e-02	-3.33	ORANGE	prosite domains	PS51054	12	1	12186	37	BHLHE41
3.585e-02	-3.33	OSBP	prosite domains	PS01013	12	1	12186	37	OSBPL1A
3.586e-02	-3.33	GPR89A (G protein-coupled receptor 89A)	protein interactions	653519	116	2	19454	50	C3AR1,TSPAN15
3.590e-02	-3.33	-	gene3d domains	2.40.160.120	12	1	14470	44	OSBPL1A
3.593e-02	-3.33	CD225	pfam domains	PF04505	13	1	17795	50	IFITM10
3.593e-02	-3.33	FA	pfam domains	PF08736	13	1	17795	50	EPB41L2
3.642e-02	-3.31	ABCF3 (ATP binding cassette subfamily F member 3)	protein interactions	55324	117	2	19454	50	PPARD,SPP1
3.652e-02	-3.31	platelet-derived growth factor receptor binding	molecular function	GO:0005161	14	1	18094	48	PDGFA
3.669e-02	-3.31	cellular detoxification	biological process	GO:1990748	117	2	18204	47	LTC4S,APOE
3.669e-02	-3.31	regulation of synapse assembly	biological process	GO:0051963	117	2	18204	47	MEF2C,WNT5A
3.684e-02	-3.30	FA	smart domains	SM01195	13	1	9717	28	EPB41L2
3.699e-02	-3.30	NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8)	protein interactions	4714	118	2	19454	50	GPR34,APOE
3.699e-02	-3.30	CEACAM8 (CEA cell adhesion molecule 8)	protein interactions	1088	118	2	19454	50	HS3ST1,APOE
3.699e-02	-3.30	DNM1 (dynamin 1)	protein interactions	1759	118	2	19454	50	ANKRD22,USP53
3.715e-02	-3.29	CXC_Chemokine_domain	interpro domains	IPR033899	14	1	18521	50	CXCL12
3.715e-02	-3.29	Ras_G-nucl-exch_fac_CS	interpro domains	IPR019804	14	1	18521	50	RGL3
3.726e-02	-3.29	negative regulation of epithelial cell migration	biological process	GO:0010633	118	2	18204	47	MEF2C,APOE
3.726e-02	-3.29	regulation of receptor-mediated endocytosis	biological process	GO:0048259	118	2	18204	47	APOC1,APOC2
3.726e-02	-3.29	biological process involved in interaction with symbiont	biological process	GO:0051702	118	2	18204	47	CSF1R,APOE
3.729e-02	-3.29	Diseases associated with surfactant metabolism	REACTOME pathways	R-HSA-5687613	10	1	10285	39	CSF2RA
3.746e-02	-3.28	developmental maturation	biological process	GO:0021700	286	3	18204	47	AXL,C1QA,WDR77
3.756e-02	-3.28	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	50	APOE,DCBLD1
3.775e-02	-3.28	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	ko01521	79	2	7161	28	PDGFA,AXL
3.775e-02	-3.28	EGFR tyrosine kinase inhibitor resistance	KEGG pathways	hsa01521	79	2	7161	28	PDGFA,AXL
3.779e-02	-3.28	regulation of canonical NF-kappaB signal transduction	biological process	GO:0043122	287	3	18204	47	ALPK1,TREM2,WNT5A
3.784e-02	-3.27	negative regulation of cellular catabolic process	biological process	GO:0031330	119	2	18204	47	TREM2,APOC1
3.788e-02	-3.27	TMEM181 (transmembrane protein 181)	protein interactions	57583	15	1	19454	50	TSPAN15
3.788e-02	-3.27	GH1 (growth hormone 1)	protein interactions	2688	15	1	19454	50	TREM2
3.788e-02	-3.27	Cenpf (centromere protein F)	protein interactions	108000	15	1	19454	50	OSBPL1A
3.788e-02	-3.27	FZD1 (frizzled class receptor 1)	protein interactions	8321	15	1	19454	50	WNT5A
3.788e-02	-3.27	FN3K (fructosamine 3 kinase)	protein interactions	64122	15	1	19454	50	AXL
3.805e-02	-3.27	cell migration involved in gastrulation	biological process	GO:0042074	15	1	18204	47	WNT5A
3.805e-02	-3.27	regulation of secondary metabolic process	biological process	GO:0043455	15	1	18204	47	WNT5A
3.805e-02	-3.27	phagocytosis, recognition	biological process	GO:0006910	15	1	18204	47	TREM2
3.805e-02	-3.27	regulation of membrane invagination	biological process	GO:1905153	15	1	18204	47	TREM2
3.805e-02	-3.27	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	47	APOE
3.805e-02	-3.27	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	47	WNT5A
3.805e-02	-3.27	negative regulation of NLRP3 inflammasome complex assembly	biological process	GO:1900226	15	1	18204	47	TREM2
3.805e-02	-3.27	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	47	APOE
3.805e-02	-3.27	regulation of melanin biosynthetic process	biological process	GO:0048021	15	1	18204	47	WNT5A
3.805e-02	-3.27	regulation of sequestering of triglyceride	biological process	GO:0010889	15	1	18204	47	TREM2
3.805e-02	-3.27	regulation of phagocytosis, engulfment	biological process	GO:0060099	15	1	18204	47	TREM2
3.805e-02	-3.27	regulation of T cell chemotaxis	biological process	GO:0010819	15	1	18204	47	WNT5A
3.805e-02	-3.27	regulation of secondary metabolite biosynthetic process	biological process	GO:1900376	15	1	18204	47	WNT5A
3.805e-02	-3.27	positive regulation of non-canonical Wnt signaling pathway	biological process	GO:2000052	15	1	18204	47	WNT5A
3.805e-02	-3.27	negative regulation of lipase activity	biological process	GO:0060192	15	1	18204	47	APOC1
3.805e-02	-3.27	detection of mechanical stimulus involved in sensory perception of pain	biological process	GO:0050966	15	1	18204	47	CXCL12
3.805e-02	-3.27	negative regulation of axon regeneration	biological process	GO:0048681	15	1	18204	47	SPP1
3.812e-02	-3.27	positive regulation of innate immune response	biological process	GO:0045089	288	3	18204	47	ALPK1,HAVCR2,WNT5A
3.814e-02	-3.27	ITGA5 (integrin subunit alpha 5)	protein interactions	3678	120	2	19454	50	SPP1,COL18A1
3.818e-02	-3.27	modulation of chemical synaptic transmission	biological process	GO:0050804	494	4	18204	47	MEF2C,ADORA3,WNT5A,APOE
3.834e-02	-3.26	EV release from cardiac cells and their functional effects	WikiPathways	WP3297	9	1	5310	23	CXCL12
3.842e-02	-3.26	regulation of cytokine production involved in immune response	biological process	GO:0002718	120	2	18204	47	WNT5A,AXL
3.842e-02	-3.26	regulation of trans-synaptic signaling	biological process	GO:0099177	495	4	18204	47	ADORA3,WNT5A,MEF2C,APOE
3.843e-02	-3.26	regulation of hydrolase activity	biological process	GO:0051336	726	5	18204	47	APOC2,RGS10,ADAP2,APOC1,MEF2C
3.846e-02	-3.26	positive regulation of secretion by cell	biological process	GO:1903532	289	3	18204	47	TREM2,SPP1,CXCL12
3.883e-02	-3.25	-	gene3d domains	1.20.5.1700	13	1	14470	44	FILIP1L
3.900e-02	-3.24	negative regulation of immune effector process	biological process	GO:0002698	121	2	18204	47	AXL,HAVCR2
3.908e-02	-3.24	heparan sulfate sulfotransferase activity	molecular function	GO:0034483	15	1	18094	48	HS3ST1
3.908e-02	-3.24	carbon-sulfur lyase activity	molecular function	GO:0016846	15	1	18094	48	LTC4S
3.930e-02	-3.24	CYB5R1 (cytochrome b5 reductase 1)	protein interactions	51706	122	2	19454	50	APOE,TSPAN15
3.943e-02	-3.23	retinol biosynthesis	BIOCYC pathways	META_PWY-6857	12	1	902	3	DHRS9
3.943e-02	-3.23	human chrX;Y	chromosome location	human chrX;Y	21	1	26134	50	CSF2RA
3.943e-02	-3.23	human chr10q26.11	chromosome location	human chr10q26.11	21	1	26134	50	RGS10
3.959e-02	-3.23	lipoprotein metabolic process	biological process	GO:0042157	122	2	18204	47	APOC1,APOE
3.961e-02	-3.23	skin-sole-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-sole-malignant_melanoma-acral_lentiginous	254	3	16828	50	ALPK1,USP53,DCBLD1
3.988e-02	-3.22	TMEM132A (transmembrane protein 132A)	protein interactions	54972	123	2	19454	50	C1QA,C1QB
3.988e-02	-3.22	NAMPT (nicotinamide phosphoribosyltransferase)	protein interactions	10135	123	2	19454	50	WDR77,AXL
4.034e-02	-3.21	Signal Transduction	REACTOME pathways	R-HSA-162582	2547	15	10285	39	DHRS9,AXL,APOE,SPP1,WNT5A,C3AR1,PDGFA,ADORA3,PPARD,CXCL12,CSF2RA,RGS10,P2RY13,APOC2,MEF2C
4.034e-02	-3.21	IG_LIKE	prosite domains	PS50835	430	4	12186	37	AXL,HAVCR2,SIGLEC8,CSF1R
4.035e-02	-3.21	CXCL17 (C-X-C motif chemokine ligand 17)	protein interactions	284340	16	1	19454	50	CXCL12
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	MEF2C
4.035e-02	-3.21	ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4)	protein interactions	9583	16	1	19454	50	TSPAN15
4.035e-02	-3.21	IL20 (interleukin 20)	protein interactions	50604	16	1	19454	50	HS3ST1
4.035e-02	-3.21	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	50	APOE
4.035e-02	-3.21	DGKQ (diacylglycerol kinase theta)	protein interactions	1609	16	1	19454	50	HAVCR2
4.035e-02	-3.21	Rab5b (RAB5B, member RAS oncogene family)	protein interactions	19344	16	1	19454	50	OSBPL1A
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	TSPAN15
4.047e-02	-3.21	IL5RA (interleukin 5 receptor subunit alpha)	protein interactions	3568	124	2	19454	50	COL18A1,HS3ST1
4.047e-02	-3.21	ACACB (acetyl-CoA carboxylase beta)	protein interactions	32	124	2	19454	50	PPARD,USP53
4.048e-02	-3.21	myeloid cell differentiation	biological process	GO:0030099	295	3	18204	47	TREM2,CSF1R,MEF2C
4.054e-02	-3.21	regulation of granulocyte differentiation	biological process	GO:0030852	16	1	18204	47	C1QC
4.054e-02	-3.21	response to ether	biological process	GO:0045472	16	1	18204	47	ABCB4
4.054e-02	-3.21	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	47	APOE
4.054e-02	-3.21	heparan sulfate proteoglycan metabolic process	biological process	GO:0030201	16	1	18204	47	HS3ST1
4.054e-02	-3.21	regulation of ATP biosynthetic process	biological process	GO:2001169	16	1	18204	47	TREM2
4.054e-02	-3.21	regulation of cell proliferation involved in kidney development	biological process	GO:1901722	16	1	18204	47	PDGFA
4.054e-02	-3.21	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	47	APOE
4.054e-02	-3.21	positive regulation of lymphocyte apoptotic process	biological process	GO:0070230	16	1	18204	47	WNT5A
4.054e-02	-3.21	neutrophil homeostasis	biological process	GO:0001780	16	1	18204	47	AXL
4.054e-02	-3.21	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	47	APOE
4.054e-02	-3.21	natural killer cell differentiation	biological process	GO:0001779	16	1	18204	47	AXL
4.054e-02	-3.21	negative regulation of astrocyte differentiation	biological process	GO:0048712	16	1	18204	47	TREM2
4.054e-02	-3.21	regulation of skeletal muscle cell proliferation	biological process	GO:0014857	16	1	18204	47	PPARD
4.054e-02	-3.21	negative regulation of neuron projection regeneration	biological process	GO:0070571	16	1	18204	47	SPP1
4.054e-02	-3.21	negative regulation of inflammasome-mediated signaling pathway	biological process	GO:0141086	16	1	18204	47	TREM2
4.054e-02	-3.21	regulation of phospholipid biosynthetic process	biological process	GO:0071071	16	1	18204	47	PDGFA
4.077e-02	-3.20	regulation of ossification	biological process	GO:0030278	124	2	18204	47	MEF2C,WNT5A
4.082e-02	-3.20	reproductive structure development	biological process	GO:0048608	296	3	18204	47	WDR77,WNT5A,AXL
4.095e-02	-3.20	Import of palmitoyl-CoA into the mitochondrial matrix	REACTOME pathways	R-HSA-200425	11	1	10285	39	PPARD
4.106e-02	-3.19	UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats)	protein interactions	55075	125	2	19454	50	RNASEH1,WDR77
4.137e-02	-3.19	pattern recognition receptor signaling pathway	biological process	GO:0002221	125	2	18204	47	ALPK1,HAVCR2
4.137e-02	-3.19	memory	biological process	GO:0007613	125	2	18204	47	APOE,TREM2
4.137e-02	-3.19	mammary gland development	biological process	GO:0030879	125	2	18204	47	WNT5A,CSF1R
4.155e-02	-3.18	regulation of phosphorylation	biological process	GO:0042325	994	6	18204	47	TREM2,PDGFA,WNT5A,APOE,CSF1R,AXL
4.162e-02	-3.18	circulatory system process	biological process	GO:0003013	508	4	18204	47	C3AR1,CXCL12,APOE,KCNMB1
4.163e-02	-3.18	floppase activity	molecular function	GO:0140328	16	1	18094	48	ABCB4
4.170e-02	-3.18	RASGEF	prosite domains	PS00720	14	1	12186	37	RGL3
4.173e-02	-3.18	central nervous system development	biological process	GO:0007417	995	6	18204	47	WNT5A,TREM2,CSF1R,AXL,C1QA,CXCL12
4.220e-02	-3.17	reproductive system development	biological process	GO:0061458	300	3	18204	47	AXL,WNT5A,WDR77
4.220e-02	-3.17	regulation of epithelial cell migration	biological process	GO:0010632	300	3	18204	47	APOE,WNT5A,MEF2C
4.235e-02	-3.16	Ez/rad/moesin-like	interpro domains	IPR000798	16	1	18521	50	EPB41L2
4.251e-02	-3.16	SDF2L1 (stromal cell derived factor 2 like 1)	protein interactions	23753	302	3	19454	50	WNT5A,COL18A1,AXL
4.252e-02	-3.16	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	23	APOE
4.257e-02	-3.16	cellular response to toxic substance	biological process	GO:0097237	127	2	18204	47	APOE,LTC4S
4.257e-02	-3.16	cardiac ventricle development	biological process	GO:0003231	127	2	18204	47	WNT5A,MEF2C
4.257e-02	-3.16	regulation of myeloid leukocyte differentiation	biological process	GO:0002761	127	2	18204	47	C1QC,TREM2
4.257e-02	-3.16	cardiac chamber morphogenesis	biological process	GO:0003206	127	2	18204	47	WNT5A,MEF2C
4.257e-02	-3.16	positive regulation of protein serine/threonine kinase activity	biological process	GO:0071902	127	2	18204	47	WNT5A,PDGFA
4.266e-02	-3.15	the visual cycle I (vertebrates)	BIOCYC pathways	META_PWY-6861	13	1	902	3	DHRS9
4.282e-02	-3.15	endonuclease activity	molecular function	GO:0004519	124	2	18094	48	RNASEH1,RNASET2
4.282e-02	-3.15	TMEM45A (transmembrane protein 45A)	protein interactions	55076	17	1	19454	50	WNT5A
4.282e-02	-3.15	KCNG4 (potassium voltage-gated channel modifier subfamily G member 4)	protein interactions	93107	17	1	19454	50	AXL
4.282e-02	-3.15	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	50	APOE
4.282e-02	-3.15	Aurkb (aurora kinase B)	protein interactions	20877	17	1	19454	50	OSBPL1A
4.282e-02	-3.15	AFD1 (acrofacial dysostosis 1, Nager type)	protein interactions	171	17	1	19454	50	AXL
4.282e-02	-3.15	BMP8A (bone morphogenetic protein 8a)	protein interactions	353500	17	1	19454	50	C1QB
4.282e-02	-3.15	FOXD4L3 (forkhead box D4 like 3)	protein interactions	286380	17	1	19454	50	APOC1
4.282e-02	-3.15	GYPC (glycophorin C (Gerbich blood group))	protein interactions	2995	17	1	19454	50	TSPAN15
4.282e-02	-3.15	HIGD1C (HIG1 hypoxia inducible domain family member 1C)	protein interactions	613227	17	1	19454	50	APOC1
4.286e-02	-3.15	TIMELESS (timeless circadian regulator)	protein interactions	8914	128	2	19454	50	WDR77,EPB41L2
4.301e-02	-3.15	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	47	APOE
4.301e-02	-3.15	type B pancreatic cell development	biological process	GO:0003323	17	1	18204	47	WNT5A
4.301e-02	-3.15	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	47	APOE
4.301e-02	-3.15	positive regulation of meiotic nuclear division	biological process	GO:0045836	17	1	18204	47	WNT5A
4.301e-02	-3.15	regulation of hematopoietic stem cell proliferation	biological process	GO:1902033	17	1	18204	47	WNT5A
4.301e-02	-3.15	negative regulation of neuroinflammatory response	biological process	GO:0150079	17	1	18204	47	TREM2
4.301e-02	-3.15	muscle cell fate commitment	biological process	GO:0042693	17	1	18204	47	MEF2C
4.301e-02	-3.15	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	47	APOE
4.301e-02	-3.15	monocyte differentiation	biological process	GO:0030224	17	1	18204	47	CSF1R
4.301e-02	-3.15	branch elongation of an epithelium	biological process	GO:0060602	17	1	18204	47	WNT5A
4.311e-02	-3.14	human chr2p25.3	chromosome location	human chr2p25.3	23	1	26134	50	RNASEH1
4.317e-02	-3.14	glial cell development	biological process	GO:0021782	128	2	18204	47	C1QA,TREM2
4.367e-02	-3.13	calcaneus	COSMIC cancer mutations	calcaneus	15	1	16828	50	ALPK1
4.417e-02	-3.12	phospholipase activator activity	molecular function	GO:0016004	17	1	18094	48	APOC2
4.417e-02	-3.12	long-chain fatty acid binding	molecular function	GO:0036041	17	1	18094	48	PPARD
4.417e-02	-3.12	apolipoprotein binding	molecular function	GO:0034185	17	1	18094	48	TREM2
4.417e-02	-3.12	low-density lipoprotein particle binding	molecular function	GO:0030169	17	1	18094	48	TREM2
4.417e-02	-3.12	phosphatidylethanolamine binding	molecular function	GO:0008429	17	1	18094	48	TREM2
4.418e-02	-3.12	monocarboxylic acid metabolic process	biological process	GO:0032787	518	4	18204	47	DHRS9,OSBPL1A,PPARD,LTC4S
4.459e-02	-3.11	P2Y receptors	REACTOME pathways	R-HSA-417957	12	1	10285	39	P2RY13
4.468e-02	-3.11	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	50	MEF2C,PPARD
4.473e-02	-3.11	receptor ligand activity	molecular function	GO:0048018	506	4	18094	48	WNT5A,PDGFA,SPP1,CXCL12
4.493e-02	-3.10	RGS_subdom1/3	interpro domains	IPR024066	17	1	18521	50	RGS10
4.494e-02	-3.10	human chr6q22.1	chromosome location	human chr6q22.1	24	1	26134	50	DCBLD1
4.502e-02	-3.10	KELCHREPEAT	prints domains	PR00501	10	1	5227	24	KLHL5
4.529e-02	-3.09	LRRC4 (leucine rich repeat containing 4)	protein interactions	64101	18	1	19454	50	SPP1
4.529e-02	-3.09	NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2)	protein interactions	254827	18	1	19454	50	ITM2B
4.529e-02	-3.09	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	50	APOE
4.529e-02	-3.09	SNX25 (sorting nexin 25)	protein interactions	83891	18	1	19454	50	TSPAN15
4.529e-02	-3.09	CSF2 (colony stimulating factor 2)	protein interactions	1437	18	1	19454	50	CSF2RA
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	KLHL5
4.534e-02	-3.09	histone deacetylase binding	molecular function	GO:0042826	128	2	18094	48	MEF2C,BHLHE41
4.534e-02	-3.09	RNA nuclease activity	molecular function	GO:0004540	128	2	18094	48	RNASEH1,RNASET2
4.549e-02	-3.09	regulation of protein kinase C signaling	biological process	GO:0090036	18	1	18204	47	WNT5A
4.549e-02	-3.09	cell-cell junction maintenance	biological process	GO:0045217	18	1	18204	47	CSF1R
4.549e-02	-3.09	response to interferon-alpha	biological process	GO:0035455	18	1	18204	47	AXL
4.549e-02	-3.09	positive regulation of neuroinflammatory response	biological process	GO:0150078	18	1	18204	47	TREM2
4.549e-02	-3.09	regulation of leukocyte tethering or rolling	biological process	GO:1903236	18	1	18204	47	CXCL12
4.549e-02	-3.09	negative regulation of myotube differentiation	biological process	GO:0010832	18	1	18204	47	BHLHE41
4.549e-02	-3.09	positive regulation of cardiocyte differentiation	biological process	GO:1905209	18	1	18204	47	MEF2C
4.549e-02	-3.09	regulation of humoral immune response mediated by circulating immunoglobulin	biological process	GO:0002923	18	1	18204	47	TREM2
4.549e-02	-3.09	ceramide transport	biological process	GO:0035627	18	1	18204	47	ABCB4
4.567e-02	-3.09	multicellular organismal process	biological process	GO:0032501	6177	22	18204	47	C1QA,MEF2C,ADAP2,KCNMB1,USP53,APOC1,COL18A1,HAVCR2,BHLHE41,C3AR1,AXL,CSF1R,SPP1,CXCL12,APOC2,TREM2,ITM2B,PDGFA,WNT5A,WDR77,APOE,PPARD
4.567e-02	-3.09	sole	COSMIC cancer mutations	sole	269	3	16828	50	ALPK1,USP53,DCBLD1
4.613e-02	-3.08	positive regulation of secretion	biological process	GO:0051047	311	3	18204	47	SPP1,CXCL12,TREM2
4.635e-02	-3.07	response to nitrogen compound	biological process	GO:1901698	1021	6	18204	47	RGS10,FOLR2,CXCL12,CD68,MEF2C,TREM2
4.636e-02	-3.07	signaling receptor activator activity	molecular function	GO:0030546	512	4	18094	48	WNT5A,PDGFA,CXCL12,SPP1
4.652e-02	-3.07	normal	COSMIC cancer mutations	normal	16	1	16828	50	CSF1R
4.654e-02	-3.07	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	10	16828	50	RNASEH1,HS3ST1,C1QA,EPB41L2,USP53,CSF2RA,C1QC,KLHL5,ANKRD22,SPP1
4.667e-02	-3.06	Nucleotide GPCRs	WikiPathways	WP80	11	1	5310	23	ADORA3
4.668e-02	-3.06	extremity	COSMIC cancer mutations	extremity	1876	10	16828	50	SPP1,ANKRD22,KLHL5,USP53,C1QC,CSF2RA,EPB41L2,HS3ST1,RNASEH1,C1QA
4.671e-02	-3.06	peptidoglycan binding	molecular function	GO:0042834	18	1	18094	48	TREM2
4.671e-02	-3.06	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	48	APOE
4.671e-02	-3.06	CXCR chemokine receptor binding	molecular function	GO:0045236	18	1	18094	48	CXCL12
4.671e-02	-3.06	racemase and epimerase activity	molecular function	GO:0016854	18	1	18094	48	DHRS9
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	ABCB4
4.674e-02	-3.06	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	5	19454	50	AXL,USP53,WDR77,CSF1R,EPB41L2
4.686e-02	-3.06	epithelial tube morphogenesis	biological process	GO:0060562	313	3	18204	47	MEF2C,CSF1R,WNT5A
4.716e-02	-3.05	HDAC7 (histone deacetylase 7)	protein interactions	51564	135	2	19454	50	PPARD,MEF2C
4.723e-02	-3.05	positive regulation of response to biotic stimulus	biological process	GO:0002833	314	3	18204	47	WNT5A,HAVCR2,ALPK1
4.737e-02	-3.05	blood vessel development	biological process	GO:0001568	530	4	18204	47	APOE,PDGFA,COL18A1,MEF2C
4.743e-02	-3.05	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	27	16828	50	C1QA,EPB41L2,ABCB4,USP53,DCBLD1,KLHL5,ACY3,FILIP1L,HAVCR2,RNASEH1,TSPAN15,WNT5A,COL18A1,PPARD,MEF2C,BHLHE41,OSBPL1A,WDR77,DHRS9,RGL3,FOLR2,P2RY13,CSF1R,C1QC,CSF2RA,ALPK1,ADAP2
4.751e-02	-3.05	determination of left/right symmetry	biological process	GO:0007368	135	2	18204	47	MEF2C,WNT5A
4.774e-02	-3.04	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	50	LTC4S
4.774e-02	-3.04	Trp53 (transformation related protein 53)	protein interactions	22059	19	1	19454	50	PDGFA
4.774e-02	-3.04	XCL2 (X-C motif chemokine ligand 2)	protein interactions	6846	19	1	19454	50	CXCL12
4.774e-02	-3.04	DRD1 (dopamine receptor D1)	protein interactions	1812	19	1	19454	50	EPB41L2
4.774e-02	-3.04	CSF1 (colony stimulating factor 1)	protein interactions	1435	19	1	19454	50	CSF1R
4.774e-02	-3.04	C14orf178 (chromosome 14 open reading frame 178)	protein interactions	283579	19	1	19454	50	WDR77
4.774e-02	-3.04	ICOSLG (inducible T cell costimulator ligand)	protein interactions	23308	19	1	19454	50	AXL
4.774e-02	-3.04	SCGB1D2 (secretoglobin family 1D member 2)	protein interactions	10647	19	1	19454	50	ALPK1
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	RGL3
4.774e-02	-3.04	MFSD4B (major facilitator superfamily domain containing 4B)	protein interactions	91749	19	1	19454	50	DHRS9
4.779e-02	-3.04	DNTTIP2 (deoxynucleotidyltransferase terminal interacting protein 2)	protein interactions	30836	136	2	19454	50	USP53,SPP1
4.779e-02	-3.04	ITGB5 (integrin subunit beta 5)	protein interactions	3693	136	2	19454	50	PPARD,SPP1
4.779e-02	-3.04	PYGB (glycogen phosphorylase B)	protein interactions	5834	136	2	19454	50	USP53,AXL
4.787e-02	-3.04	regulation of signal transduction	biological process	GO:0009966	3114	13	18204	47	HAVCR2,ALPK1,MEF2C,TREM2,WNT5A,PDGFA,APOE,PPARD,AXL,CSF1R,TSPAN15,RGS10,CXCL12
4.795e-02	-3.04	positive regulation of lymphocyte chemotaxis	biological process	GO:0140131	19	1	18204	47	WNT5A
4.795e-02	-3.04	excitatory synapse assembly	biological process	GO:1904861	19	1	18204	47	WNT5A
4.795e-02	-3.04	leukotriene biosynthetic process	biological process	GO:0019370	19	1	18204	47	LTC4S
4.795e-02	-3.04	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	47	APOE
4.795e-02	-3.04	establishment of epithelial cell apical/basal polarity	biological process	GO:0045198	19	1	18204	47	WNT5A
4.795e-02	-3.04	paraxial mesoderm development	biological process	GO:0048339	19	1	18204	47	WNT5A
4.795e-02	-3.04	tolerance induction	biological process	GO:0002507	19	1	18204	47	HAVCR2
4.795e-02	-3.04	regulation of skeletal muscle cell differentiation	biological process	GO:2001014	19	1	18204	47	MEF2C
4.795e-02	-3.04	regulation of microglial cell activation	biological process	GO:1903978	19	1	18204	47	TREM2
4.795e-02	-3.04	negative regulation of toll-like receptor 4 signaling pathway	biological process	GO:0034144	19	1	18204	47	TREM2
4.795e-02	-3.04	negative regulation of amyloid precursor protein biosynthetic process	biological process	GO:0042985	19	1	18204	47	ITM2B
4.795e-02	-3.04	regulation of hair follicle development	biological process	GO:0051797	19	1	18204	47	WNT5A
4.795e-02	-3.04	post-anal tail morphogenesis	biological process	GO:0036342	19	1	18204	47	WNT5A
4.795e-02	-3.04	presynapse assembly	biological process	GO:0099054	19	1	18204	47	WNT5A
4.795e-02	-3.04	detection of temperature stimulus involved in sensory perception of pain	biological process	GO:0050965	19	1	18204	47	CXCL12
4.795e-02	-3.04	positive regulation of bone resorption	biological process	GO:0045780	19	1	18204	47	SPP1
4.795e-02	-3.04	pericardium development	biological process	GO:0060039	19	1	18204	47	WNT5A
4.822e-02	-3.03	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	REACTOME pathways	R-HSA-5140745	13	1	10285	39	WNT5A
4.828e-02	-3.03	ATP5PB (ATP synthase peripheral stalk-membrane subunit b)	protein interactions	515	318	3	19454	50	C3AR1,WDR77,SPP1
4.835e-02	-3.03	coated vesicle	cellular component	GO:0030135	319	3	19108	49	WNT5A,ABCB4,APOE
4.842e-02	-3.03	TTF2 (transcription termination factor 2)	protein interactions	8458	137	2	19454	50	PPARD,HAVCR2
4.877e-02	-3.02	cell recognition	biological process	GO:0008037	137	2	18204	47	TREM2,FOLR2
4.884e-02	-3.02	clathrin-coated vesicle membrane	cellular component	GO:0030665	138	2	19108	49	WNT5A,APOE
4.910e-02	-3.01	cognition	biological process	GO:0050890	319	3	18204	47	APOE,TREM2,MEF2C
4.912e-02	-3.01	the visual cycle I (vertebrates)	BIOCYC pathways	HUMAN_PWY-6861	15	1	902	3	DHRS9
4.930e-02	-3.01	nervous system development	biological process	GO:0007399	2185	10	18204	47	TREM2,ITM2B,WNT5A,APOE,PPARD,C1QA,AXL,MEF2C,CSF1R,CXCL12
4.941e-02	-3.01	regulation of wound healing	biological process	GO:0061041	138	2	18204	47	APOE,PDGFA
4.941e-02	-3.01	regulation of protein localization to cell periphery	biological process	GO:1904375	138	2	18204	47	TREM2,EPB41L2
4.968e-02	-3.00	CDCA5 (cell division cycle associated 5)	protein interactions	113130	139	2	19454	50	WDR77,BHLHE41
4.977e-02	-3.00	ITGB1 (integrin subunit beta 1)	protein interactions	3688	322	3	19454	50	COL18A1,SPP1,AXL