Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
2.235e-13	-29.13	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	31	16828	48	GNA14,PDLIM5,ARHGEF26,TTC28,CTNND2,ITPR2,TRPS1,GRAMD1C,GULP1,CDC14A,SLC1A2,ATP13A4,PLCB4,LUZP2,ATP10B,PREX2,SLC1A3,TRPM3,LSAMP,GLI3,MERTK,RFX4,ZNRF3,MAML2,IGSF11,RPE65,NKAIN3,GPC5,DAAM2,SPAG16,LRIG1
4.176e-11	-23.90	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	28	16828	48	LUZP2,PREX2,ATP10B,CDC14A,GRAMD1C,PLCB4,SLC1A2,ITPR2,TRPS1,ARHGEF26,PDLIM5,GNA14,CTNND2,TTC28,NKAIN3,RPE65,IGSF11,LRIG1,SPAG16,DAAM2,GPC5,MAML2,MERTK,ZNRF3,RFX4,LSAMP,GLI3,SLC1A3
3.431e-10	-21.79	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	24	16828	48	NPAS3,MAML2,NKAIN3,GPC5,SPAG16,LRIG1,LSAMP,GLI3,SLC1A3,RFX4,GULP1,GRAMD1C,SLC1A2,ATP13A4,PLCB4,LUZP2,PREX2,APC,GNA14,PDLIM5,CTNND2,TTC28,ITPR2,PLEKHA7
3.431e-10	-21.79	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	24	16828	48	RFX4,ITPR2,PLEKHA7,TTC28,CTNND2,SLC1A3,LSAMP,GLI3,APC,GNA14,PDLIM5,GPC5,SPAG16,PREX2,LRIG1,LUZP2,NKAIN3,SLC1A2,ATP13A4,MAML2,PLCB4,NPAS3,GRAMD1C,GULP1
5.405e-08	-16.73	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	39	16828	48	FOLH1,LSAMP,GLI3,SLC1A3,TRPM3,PITPNC1,QKI,RFX4,FGFR2,PTPRZ1,MAML2,NPAS3,IGSF11,NKAIN3,RPE65,TNIK,GPC5,DAAM2,LRIG1,SPAG16,GNA14,APC,PDLIM5,CTNND2,TTC28,ITPR2,PLEKHA7,ABLIM1,TRPS1,NFIA,GULP1,GRAMD1C,GLIS3,SLC1A2,ATP13A4,PLCB4,LUZP2,ATP10B,PREX2
1.065e-07	-16.06	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	40	16828	48	ATP10B,PREX2,LUZP2,SLC1A2,GLIS3,ATP13A4,PLCB4,GULP1,GRAMD1C,TRPS1,ITPR2,PLEKHA7,ABLIM1,CTNND2,TTC28,APOE,GNA14,APC,ARHGEF26,PDLIM5,TNIK,GPC5,SPAG16,LRIG1,IGSF11,NKAIN3,RPE65,MAML2,FGFR2,ATP1A2,PTPRZ1,QKI,RFX4,MERTK,GLI3,LSAMP,SLC1A3,TRPM3,CLU,FOLH1
1.389e-07	-15.79	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	13	16828	48	PLCB4,MAML2,SLC1A2,GRAMD1C,ATP1A2,SPAG16,PREX2,GPC5,LUZP2,NKAIN3,LSAMP,PDLIM5,GNA14
1.498e-07	-15.71	cerebellum	COSMIC cancer mutations	cerebellum	769	13	16828	48	QKI,GPC5,SPAG16,IGSF11,ITPR2,ABLIM1,LUZP2,CTNND2,MAML2,NPAS3,GRAMD1C,APC,PTPRZ1
2.080e-07	-15.39	nervous system development	biological process	GO:0007399	2185	20	18204	48	NFIA,CLU,PTPRZ1,MERTK,LSAMP,RFX4,QKI,ATP1A2,LRIG1,SLC1A3,SLC1A2,FGFR2,TNIK,MSI2,APOE,DAAM2,PREX2,APC,GLI3,CTNND2
4.137e-07	-14.70	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	8	18204	48	ZNRF3,CTNND2,FGFR2,GLI3,APC,DAAM2,APOE,GPC5
5.049e-07	-14.50	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	15	16828	48	LSAMP,GNA14,APC,NFIA,MERTK,SLC1A2,NPAS3,ATP1A2,GRAMD1C,FGFR2,TNIK,PREX2,SPAG16,NKAIN3,LUZP2
5.049e-07	-14.50	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	15	16828	48	NFIA,MERTK,LSAMP,APC,GNA14,TNIK,PREX2,SPAG16,NKAIN3,LUZP2,SLC1A2,NPAS3,ATP1A2,GRAMD1C,FGFR2
5.483e-07	-14.42	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	42	16828	48	TRPS1,NFIA,FNBP1,PLEKHA7,ABLIM1,ITPR2,APOE,CTNND2,TTC28,PDLIM5,GNA14,APC,PREX2,ATP10B,LUZP2,MSI2,PLCB4,GLIS3,SLC1A2,ATP13A4,GULP1,ZNRF3,RFX4,QKI,MERTK,LSAMP,GLI3,PITPNC1,SLC1A3,TRPM3,CLU,SPAG16,LRIG1,TNIK,DAAM2,GPC5,NKAIN3,IGSF11,MAML2,NPAS3,PTPRZ1,FGFR2
6.796e-07	-14.20	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	26	16828	48	MAML2,ATP1A2,TNIK,GPC5,SPAG16,NKAIN3,LSAMP,GLI3,CLU,FOLH1,QKI,MERTK,ATP13A4,SLC1A2,PLCB4,GULP1,ATP10B,PREX2,LUZP2,CTNND2,TTC28,GNA14,APC,PDLIM5,ITPR2,PLEKHA7
6.814e-07	-14.20	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	28	16828	48	GULP1,PLCB4,ATP13A4,SLC1A2,LUZP2,PREX2,ATP10B,PDLIM5,APC,GNA14,TTC28,CTNND2,PLEKHA7,ITPR2,TRPS1,ATP1A2,MAML2,NKAIN3,SPAG16,GPC5,TNIK,FOLH1,CLU,SLC1A3,LSAMP,GLI3,MERTK,QKI
6.984e-07	-14.17	brainstem	COSMIC cancer mutations	brainstem	3102	24	16828	48	ITPR2,PDLIM5,GNA14,CTNND2,TTC28,LUZP2,PREX2,ATP10B,ATP13A4,SLC1A2,ZNRF3,QKI,GLI3,LSAMP,SLC1A3,NKAIN3,RPE65,SPAG16,TNIK,GPC5,PTPRZ1,FGFR2,MAML2,NPAS3
7.347e-07	-14.12	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	15	16828	48	PLCB4,TNIK,GPC5,SPAG16,LUZP2,NKAIN3,RPE65,CTNND2,TTC28,LSAMP,GNA14,PDLIM5,FOLH1,ITPR2,MERTK
7.439e-07	-14.11	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	10	16828	48	GULP1,GRAMD1C,ARHGEF26,PDLIM5,CTNND2,ATP13A4,LSAMP,MAML2,TRPM3,GPC5
9.065e-07	-13.91	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	20	16828	48	ITPR2,PLEKHA7,CTNND2,TTC28,LSAMP,GLI3,SLC1A3,APC,FOLH1,GPC5,ATP10B,SPAG16,PREX2,LUZP2,NKAIN3,SLC1A2,MAML2,FGFR2,GRAMD1C,PTPRZ1
1.683e-06	-13.29	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	11	16828	48	CTNND2,NPAS3,MAML2,GRAMD1C,APC,PTPRZ1,SPAG16,IGSF11,ITPR2,ABLIM1,LUZP2
1.709e-06	-13.28	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	11	16828	48	PTPRZ1,GRAMD1C,APC,NPAS3,MAML2,CTNND2,ABLIM1,LUZP2,IGSF11,ITPR2,SPAG16
1.759e-06	-13.25	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	21	16828	48	ATP13A4,MAML2,PTPRZ1,TNIK,GPC5,ATP10B,SPAG16,PREX2,LUZP2,NKAIN3,RPE65,CTNND2,TTC28,GLI3,LSAMP,SLC1A3,GNA14,PDLIM5,QKI,ZNRF3,ITPR2
2.245e-06	-13.01	lymph_node	COSMIC cancer mutations	lymph_node	1703	17	16828	48	ATP13A4,MAML2,GRAMD1C,GULP1,FGFR2,GPC5,TNIK,CTNND2,SLC1A3,TRPM3,LSAMP,APC,PDLIM5,FOLH1,ARHGEF26,TRPS1,ITPR2
2.248e-06	-13.01	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	48	GRAMD1C,ATP13A4,SLC1A2,GLIS3,LUZP2,PREX2,PDLIM5,ARHGEF26,GNA14,APC,TTC28,CTNND2,PLEKHA7,ITPR2,NFIA,PTPRZ1,FGFR2,MAML2,NKAIN3,SPAG16,GPC5,DAAM2,TNIK,SLC1A3,LSAMP,GLI3
2.248e-06	-13.01	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	48	MAML2,FGFR2,PTPRZ1,TNIK,GPC5,DAAM2,SPAG16,NKAIN3,GLI3,LSAMP,SLC1A3,ATP13A4,GLIS3,SLC1A2,GRAMD1C,PREX2,LUZP2,CTNND2,TTC28,APC,GNA14,ARHGEF26,PDLIM5,NFIA,ITPR2,PLEKHA7
2.370e-06	-12.95	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	13	16828	48	PLCB4,RPE65,LUZP2,NKAIN3,GPC5,SPAG16,GNA14,FOLH1,TTC28,CTNND2,LSAMP,ITPR2,MERTK
2.568e-06	-12.87	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	16	16828	48	QKI,PLEKHA7,ITPR2,LSAMP,GLI3,SLC1A3,CTNND2,TTC28,PDLIM5,PREX2,SPAG16,GPC5,NKAIN3,LUZP2,MAML2,PLCB4
2.568e-06	-12.87	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	16	16828	48	MAML2,PLCB4,GPC5,PREX2,SPAG16,LUZP2,NKAIN3,CTNND2,TTC28,LSAMP,GLI3,SLC1A3,PDLIM5,QKI,ITPR2,PLEKHA7
2.626e-06	-12.85	regulation of Wnt signaling pathway	biological process	GO:0030111	339	8	18204	48	APOE,GPC5,ZNRF3,CTNND2,FGFR2,GLI3,APC,DAAM2
3.021e-06	-12.71	mouth	COSMIC cancer mutations	mouth	9004	41	16828	48	ATP10B,PREX2,ATP13A4,SLC1A2,PLCB4,GULP1,CDC14A,FNBP1,TRPS1,ITPR2,ABLIM1,PLEKHA7,TTC28,CTNND2,APOE,APC,PDLIM5,ARHGEF26,GPC5,DAAM2,TNIK,LRIG1,SPAG16,IGSF11,RPE65,MAML2,NPAS3,ATP1A2,FGFR2,PTPRZ1,QKI,RFX4,ZNRF3,MERTK,SLC1A3,PITPNC1,TRPM3,GLI3,LSAMP,FOLH1,CLU
3.365e-06	-12.60	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	13	19454	50	LSAMP,MAML2,TRPM3,SLC1A3,APOE,APC,PTPRZ1,MSI2,CLU,QKI,ATP1A2,TRPS1,ABLIM1
3.733e-06	-12.50	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	19	16828	48	PLEKHA7,ITPR2,SLC1A3,LSAMP,GLI3,TTC28,CTNND2,FOLH1,APC,PREX2,SPAG16,GPC5,ATP10B,NKAIN3,LUZP2,MAML2,SLC1A2,PTPRZ1,GRAMD1C
3.733e-06	-12.50	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	19	16828	48	FOLH1,APC,LSAMP,GLI3,SLC1A3,CTNND2,TTC28,PLEKHA7,ITPR2,PTPRZ1,GRAMD1C,MAML2,SLC1A2,LUZP2,NKAIN3,SPAG16,PREX2,GPC5,ATP10B
4.189e-06	-12.38	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	47	16828	48	ATP10B,GULP1,GRAMD1C,CDC14A,SLC1A2,PLCB4,ITPR2,PLEKHA7,ABLIM1,FNBP1,TRPS1,ARHGEF26,CTNND2,TTC28,NKAIN3,RPE65,GPC5,DAAM2,SPAG16,ATP1A2,NPAS3,MERTK,QKI,ZNRF3,RFX4,FOLH1,GLI3,PITPNC1,TRPM3,LUZP2,PREX2,GLIS3,ATP13A4,MSI2,NFIA,APC,GNA14,PDLIM5,IGSF11,TNIK,LRIG1,FGFR2,PTPRZ1,MAML2,CLU,LSAMP,SLC1A3
6.808e-06	-11.90	mammary gland specification	biological process	GO:0060594	2	2	18204	48	FGFR2,GLI3
6.972e-06	-11.87	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	24	16828	48	PTPRZ1,FGFR2,NPAS3,RPE65,IGSF11,SPAG16,TNIK,GPC5,DAAM2,CLU,GLI3,LSAMP,SLC1A3,PITPNC1,TRPM3,ZNRF3,GULP1,GRAMD1C,MSI2,LUZP2,PREX2,ATP10B,CTNND2,PLEKHA7
6.972e-06	-11.87	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	24	16828	48	MSI2,GULP1,GRAMD1C,PREX2,ATP10B,LUZP2,CTNND2,PLEKHA7,NPAS3,PTPRZ1,FGFR2,SPAG16,TNIK,GPC5,DAAM2,RPE65,IGSF11,LSAMP,GLI3,TRPM3,SLC1A3,PITPNC1,CLU,ZNRF3
7.025e-06	-11.87	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	36	16828	48	SLC1A3,LSAMP,GLI3,FOLH1,CLU,QKI,RFX4,MERTK,MAML2,ATP1A2,FGFR2,GPC5,SPAG16,LRIG1,IGSF11,RPE65,NKAIN3,TTC28,CTNND2,APOE,APC,GNA14,PDLIM5,ARHGEF26,ITPR2,ABLIM1,PLEKHA7,SLC1A2,GLIS3,ATP13A4,PLCB4,GRAMD1C,GULP1,ATP10B,PREX2,LUZP2
7.580e-06	-11.79	system development	biological process	GO:0048731	3533	23	18204	48	ATP1A2,TRPS1,FGFR2,CTNND2,PREX2,MSI2,TNIK,LRIG1,SLC1A2,SLC1A3,RPE65,MERTK,PTPRZ1,NFIA,CLU,QKI,LSAMP,RFX4,GLI3,APC,DAAM2,PDLIM5,APOE
8.486e-06	-11.68	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	5	16828	48	LSAMP,CTNND2,LUZP2,NKAIN3,PLEKHA7
8.945e-06	-11.62	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	35	16828	48	MAML2,PTPRZ1,FGFR2,ATP1A2,SPAG16,LRIG1,TNIK,GPC5,DAAM2,RPE65,IGSF11,GLI3,LSAMP,PITPNC1,TRPM3,FOLH1,ZNRF3,RFX4,QKI,MERTK,PLCB4,ATP13A4,SLC1A2,CDC14A,GULP1,PREX2,CTNND2,TTC28,ARHGEF26,APC,TRPS1,FNBP1,PLEKHA7,ABLIM1,ITPR2
9.792e-06	-11.53	cell morphogenesis	biological process	GO:0000902	687	10	18204	48	PREX2,GLI3,FGFR2,CTNND2,SLC1A3,ARHGEF26,TNIK,CLU,NFIA,PTPRZ1
1.461e-05	-11.13	multicellular organism development	biological process	GO:0007275	3957	24	18204	48	NFIA,CLU,MERTK,PTPRZ1,RFX4,LSAMP,QKI,SLC1A3,SLC1A2,LRIG1,RPE65,PDLIM5,APOE,DAAM2,GLI3,APC,ZNRF3,ATP1A2,FGFR2,TRPS1,MSI2,TNIK,PREX2,CTNND2
1.750e-05	-10.95	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	25	16828	48	GRAMD1C,PLCB4,SLC1A2,GLIS3,LUZP2,PREX2,ATP10B,ARHGEF26,CTNND2,PLEKHA7,TRPS1,NFIA,PTPRZ1,FGFR2,ATP1A2,NPAS3,MAML2,IGSF11,SPAG16,TNIK,GLI3,PITPNC1,MERTK,ZNRF3,RFX4
1.758e-05	-10.95	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	25	16828	48	IGSF11,SPAG16,TNIK,PTPRZ1,FGFR2,ATP1A2,NPAS3,MAML2,MERTK,ZNRF3,RFX4,GLI3,PITPNC1,LUZP2,PREX2,ATP10B,GRAMD1C,PLCB4,GLIS3,SLC1A2,PLEKHA7,NFIA,TRPS1,ARHGEF26,CTNND2
1.776e-05	-10.94	tibia	COSMIC cancer mutations	tibia	836	11	16828	48	TRPM3,LSAMP,CTNND2,PREX2,QKI,TNIK,ABLIM1,PLEKHA7,NKAIN3,LUZP2,IGSF11
1.811e-05	-10.92	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	43	16828	48	TTC28,CTNND2,PDLIM5,ARHGEF26,APC,GNA14,NFIA,FNBP1,ABLIM1,PLEKHA7,ITPR2,PLCB4,MSI2,SLC1A2,GLIS3,ATP13A4,CDC14A,GRAMD1C,GULP1,PREX2,ATP10B,LUZP2,TRPM3,SLC1A3,LSAMP,GLI3,FOLH1,RFX4,QKI,MERTK,MAML2,NPAS3,PTPRZ1,ATP1A2,FGFR2,SPAG16,LRIG1,GPC5,DAAM2,TNIK,RPE65,NKAIN3,IGSF11
1.811e-05	-10.92	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	43	16828	48	GULP1,GRAMD1C,CDC14A,SLC1A2,PLCB4,ATP10B,ARHGEF26,CTNND2,TTC28,ITPR2,PLEKHA7,ABLIM1,FNBP1,ATP1A2,NPAS3,NKAIN3,RPE65,DAAM2,GPC5,SPAG16,FOLH1,GLI3,TRPM3,MERTK,QKI,RFX4,ATP13A4,GLIS3,MSI2,LUZP2,PREX2,GNA14,APC,PDLIM5,NFIA,FGFR2,PTPRZ1,MAML2,IGSF11,TNIK,LRIG1,LSAMP,SLC1A3
2.014e-05	-10.81	pharynx	COSMIC cancer mutations	pharynx	2696	20	16828	48	RFX4,NFIA,QKI,PITPNC1,CTNND2,TTC28,CLU,FOLH1,APC,PREX2,GPC5,DAAM2,LUZP2,NPAS3,ATP13A4,SLC1A2,PTPRZ1,GULP1,FGFR2,ATP1A2
2.057e-05	-10.79	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	25	16828	48	IGSF11,SPAG16,TNIK,PTPRZ1,FGFR2,ATP1A2,NPAS3,MAML2,MERTK,ZNRF3,RFX4,GLI3,PITPNC1,LUZP2,PREX2,ATP10B,GRAMD1C,PLCB4,GLIS3,SLC1A2,PLEKHA7,NFIA,TRPS1,ARHGEF26,CTNND2
2.443e-05	-10.62	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	35	16828	48	ZNRF3,RFX4,QKI,CLU,FOLH1,LSAMP,GLI3,TRPM3,PITPNC1,RPE65,SPAG16,LRIG1,DAAM2,PTPRZ1,FGFR2,ATP1A2,MAML2,NPAS3,ITPR2,TRPS1,NFIA,FNBP1,ARHGEF26,PDLIM5,GNA14,APC,CTNND2,TTC28,PREX2,ATP10B,CDC14A,GRAMD1C,PLCB4,ATP13A4,SLC1A2
2.443e-05	-10.62	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	35	16828	48	QKI,ZNRF3,RFX4,LSAMP,GLI3,PITPNC1,TRPM3,CLU,FOLH1,DAAM2,LRIG1,SPAG16,RPE65,MAML2,NPAS3,FGFR2,ATP1A2,PTPRZ1,FNBP1,TRPS1,NFIA,ITPR2,CTNND2,TTC28,GNA14,APC,ARHGEF26,PDLIM5,ATP10B,PREX2,ATP13A4,SLC1A2,PLCB4,GRAMD1C,CDC14A
2.501e-05	-10.60	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	17	16828	48	IGSF11,GPC5,PREX2,FGFR2,GULP1,GRAMD1C,PTPRZ1,MSI2,PLCB4,ITPR2,ABLIM1,ZNRF3,TRPS1,APC,PDLIM5,LSAMP,TRPM3
3.231e-05	-10.34	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	12	18204	48	TNIK,APOE,RFX4,PTPRZ1,SPAG16,CDC14A,ABLIM1,CTNND2,FGFR2,GLI3,PREX2,ARHGEF26
3.268e-05	-10.33	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	35	16828	48	MERTK,QKI,RFX4,FOLH1,CLU,SLC1A3,GLI3,LSAMP,IGSF11,NKAIN3,GPC5,DAAM2,TNIK,LRIG1,SPAG16,PTPRZ1,MAML2,ITPR2,ABLIM1,PLEKHA7,GNA14,APC,PDLIM5,ARHGEF26,TTC28,CTNND2,LUZP2,ATP10B,PREX2,GRAMD1C,GULP1,ATP13A4,GLIS3,SLC1A2,PLCB4
4.191e-05	-10.08	Ig_3	pfam domains	PF13927	141	5	17795	49	IGSF11,LRIG1,FGFR2,MERTK,LSAMP
4.755e-05	-9.95	face	COSMIC cancer mutations	face	2139	17	16828	48	IGSF11,PREX2,GPC5,PTPRZ1,GRAMD1C,FGFR2,GULP1,PLCB4,MSI2,ABLIM1,ITPR2,TRPS1,ZNRF3,PDLIM5,APC,TRPM3,LSAMP
4.822e-05	-9.94	cell projection organization	biological process	GO:0030030	1200	12	18204	48	ARHGEF26,FGFR2,CTNND2,ABLIM1,GLI3,CDC14A,PREX2,PTPRZ1,SPAG16,APOE,TNIK,RFX4
5.372e-05	-9.83	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	3	14470	43	ATP13A4,ATP10B,ATP1A2
5.477e-05	-9.81	anatomical structure development	biological process	GO:0048856	5207	27	18204	48	PDLIM5,APOE,DAAM2,ZNRF3,APC,GLI3,CLU,NFIA,MERTK,PTPRZ1,LSAMP,RFX4,QKI,LRIG1,SLC1A2,SLC1A3,ARHGEF26,RPE65,SPAG16,TNIK,MSI2,PREX2,CTNND2,ABLIM1,ATP1A2,TRPS1,FGFR2
5.605e-05	-9.79	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	32	SLC1A3,SLC1A2
5.605e-05	-9.79	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	32	SLC1A2,SLC1A3
6.292e-05	-9.67	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	46	SLC1A3,SLC1A2
6.292e-05	-9.67	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	46	SLC1A2,SLC1A3
6.644e-05	-9.62	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	48	SLC1A3,SLC1A2,ATP1A2
6.774e-05	-9.60	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	48	SLC1A2,SLC1A3
6.774e-05	-9.60	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	2	18204	48	CLU,APOE
6.774e-05	-9.60	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	48	SLC1A2,SLC1A3
7.382e-05	-9.51	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	30	16828	48	GRAMD1C,GLIS3,SLC1A2,LUZP2,PREX2,ATP10B,PDLIM5,APC,APOE,CTNND2,TTC28,PLEKHA7,ITPR2,TRPS1,NFIA,PTPRZ1,FGFR2,MAML2,NPAS3,NKAIN3,SPAG16,GPC5,CLU,FOLH1,LSAMP,GLI3,SLC1A3,TRPM3,MERTK,ZNRF3
7.458e-05	-9.50	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	28	16828	48	PTPRZ1,FGFR2,MAML2,NPAS3,LRIG1,TNIK,DAAM2,CLU,GLI3,LSAMP,SLC1A3,PITPNC1,MERTK,QKI,CDC14A,GRAMD1C,MSI2,PLCB4,ATP13A4,PREX2,ATP10B,GNA14,APC,CTNND2,PLEKHA7,ABLIM1,ITPR2,TRPS1
7.458e-05	-9.50	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	28	16828	48	MERTK,QKI,CLU,GLI3,LSAMP,PITPNC1,SLC1A3,TNIK,DAAM2,LRIG1,FGFR2,PTPRZ1,NPAS3,MAML2,ITPR2,PLEKHA7,ABLIM1,TRPS1,GNA14,APC,CTNND2,ATP10B,PREX2,GRAMD1C,CDC14A,ATP13A4,MSI2,PLCB4
9.200e-05	-9.29	Cation_ATPase	pfam domains	PF13246	32	3	17795	49	ATP10B,ATP13A4,ATP1A2
9.521e-05	-9.26	CATATPASE	prints domains	PR00119	35	3	5227	14	ATP1A2,ATP13A4,ATP10B
1.014e-04	-9.20	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	48	SLC1A3,SLC1A2
1.014e-04	-9.20	D-amino acid transport	biological process	GO:0042940	6	2	18204	48	SLC1A3,SLC1A2
1.014e-04	-9.20	mammary gland formation	biological process	GO:0060592	6	2	18204	48	GLI3,FGFR2
1.064e-04	-9.15	GLI-like	interpro domains	IPR043359	6	2	18521	50	GLI3,GLIS3
1.138e-04	-9.08	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	47	16828	48	PDLIM5,GNA14,APC,NFIA,MSI2,GLIS3,ATP13A4,LUZP2,PREX2,CLU,SLC1A3,LSAMP,PTPRZ1,FGFR2,MAML2,IGSF11,LRIG1,TNIK,ARHGEF26,APOE,TTC28,CTNND2,ABLIM1,PLEKHA7,ITPR2,TRPS1,FNBP1,CDC14A,GULP1,PLCB4,SLC1A2,ATP10B,FOLH1,PITPNC1,TRPM3,GLI3,MERTK,RFX4,ZNRF3,QKI,ATP1A2,NPAS3,RPE65,NKAIN3,SPAG16,GPC5,DAAM2
1.203e-04	-9.03	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	8	16828	48	CTNND2,LSAMP,GPC5,SPAG16,IGSF11,NKAIN3,LUZP2,PLEKHA7
1.241e-04	-8.99	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	3	18521	50	ATP1A2,ATP13A4,ATP10B
1.241e-04	-8.99	P_typ_ATPase	interpro domains	IPR001757	36	3	18521	50	ATP10B,ATP1A2,ATP13A4
1.241e-04	-8.99	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	3	18521	50	ATP10B,ATP1A2,ATP13A4
1.241e-04	-8.99	ATPase_P-typ_P_site	interpro domains	IPR018303	36	3	18521	50	ATP10B,ATP13A4,ATP1A2
1.241e-04	-8.99	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	3	18521	50	ATP13A4,ATP1A2,ATP10B
1.259e-04	-8.98	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	13	16828	48	CLU,ATP1A2,GULP1,FGFR2,PITPNC1,ATP13A4,SLC1A2,TTC28,CTNND2,RFX4,PREX2,NFIA,QKI
1.259e-04	-8.98	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	13	16828	48	CLU,TTC28,CTNND2,PITPNC1,QKI,RFX4,NFIA,ATP1A2,GULP1,FGFR2,ATP13A4,SLC1A2,PREX2
1.348e-04	-8.91	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	3	18521	50	ATP13A4,ATP1A2,ATP10B
1.388e-04	-8.88	EDTRNSPORT	prints domains	PR00173	7	2	5227	14	SLC1A3,SLC1A2
1.407e-04	-8.87	gallbladder	COSMIC cancer mutations	gallbladder	2821	19	16828	48	PREX2,LRIG1,TNIK,LUZP2,NKAIN3,PLCB4,PTPRZ1,CDC14A,FGFR2,TRPS1,ZNRF3,ITPR2,TRPM3,PITPNC1,CTNND2,FOLH1,PDLIM5,CLU,APC
1.407e-04	-8.87	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	19	16828	48	ZNRF3,TRPS1,ITPR2,CTNND2,PITPNC1,TRPM3,APC,CLU,FOLH1,PDLIM5,TNIK,LRIG1,PREX2,LUZP2,NKAIN3,PLCB4,FGFR2,CDC14A,PTPRZ1
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A3,SLC1A2
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.546e-04	-8.77	SDF	pfam domains	PF00375	7	2	17795	49	SLC1A3,SLC1A2
1.560e-04	-8.77	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	43	16828	48	PLCB4,SLC1A2,CDC14A,GULP1,GRAMD1C,ATP10B,CTNND2,TTC28,ARHGEF26,FNBP1,PLEKHA7,ABLIM1,ITPR2,NPAS3,ATP1A2,SPAG16,DAAM2,GPC5,NKAIN3,RPE65,GLI3,TRPM3,FOLH1,RFX4,QKI,MERTK,MSI2,GLIS3,ATP13A4,PREX2,LUZP2,PDLIM5,GNA14,APC,NFIA,MAML2,PTPRZ1,FGFR2,LRIG1,TNIK,IGSF11,LSAMP,SLC1A3
1.630e-04	-8.72	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	3	14470	43	ATP10B,ATP1A2,ATP13A4
1.630e-04	-8.72	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	3	14470	43	ATP13A4,ATP10B,ATP1A2
1.794e-04	-8.63	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	43	SLC1A3,SLC1A2
1.795e-04	-8.63	plasma membrane	cellular component	GO:0005886	5538	27	19108	50	RPE65,APOE,NKAIN3,FOLH1,ATP10B,IGSF11,GNA14,ATP1A2,TRPM3,MERTK,SLC1A3,ZNRF3,PTPRZ1,PREX2,SLC1A2,ITPR2,ATP13A4,CTNND2,TNIK,FNBP1,GRAMD1C,LSAMP,LRIG1,GPC5,FGFR2,PLCB4,APC
1.887e-04	-8.58	protein import	biological process	GO:0017038	8	2	18204	48	CLU,APOE
1.993e-04	-8.52	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	21	16828	48	LUZP2,GPC5,DAAM2,ATP10B,PREX2,LRIG1,SPAG16,GRAMD1C,ATP1A2,FGFR2,PTPRZ1,GLIS3,ATP13A4,PLCB4,ITPR2,PLEKHA7,RFX4,APC,CTNND2,TRPM3,PITPNC1
2.170e-04	-8.44	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	18	16828	48	PLEKHA7,MERTK,ZNRF3,NFIA,FOLH1,APOE,GLI3,TRPM3,CTNND2,TTC28,LUZP2,PREX2,SPAG16,PTPRZ1,FGFR2,NPAS3,MAML2,GLIS3
2.170e-04	-8.44	embryonal	COSMIC cancer mutations	embryonal	2659	18	16828	48	NPAS3,MAML2,GLIS3,PTPRZ1,FGFR2,SPAG16,PREX2,LUZP2,GLI3,APOE,TRPM3,CTNND2,TTC28,FOLH1,ZNRF3,NFIA,PLEKHA7,MERTK
2.225e-04	-8.41	central nervous system development	biological process	GO:0007417	995	10	18204	48	DAAM2,FGFR2,GLI3,ATP1A2,SLC1A2,RFX4,QKI,MSI2,CLU,PTPRZ1
2.295e-04	-8.38	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	41	SLC1A3,SLC1A2
2.295e-04	-8.38	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	41	SLC1A2,SLC1A3
2.337e-04	-8.36	ATPASE_E1_E2	prosite domains	PS00154	36	3	12186	41	ATP1A2,ATP13A4,ATP10B
2.373e-04	-8.35	NAKATPASE	prints domains	PR00121	9	2	5227	14	ATP1A2,ATP13A4
2.388e-04	-8.34	platelet dense tubular network membrane	cellular component	GO:0031095	9	2	19108	50	ITPR2,IRAG1
2.412e-04	-8.33	regulation of oligodendrocyte differentiation	biological process	GO:0048713	46	3	18204	48	PTPRZ1,DAAM2,QKI
2.533e-04	-8.28	lipid transport	biological process	GO:0006869	339	6	18204	48	CLU,PITPNC1,ATP10B,APOE,GULP1,GRAMD1C
2.706e-04	-8.21	glial cell differentiation	biological process	GO:0010001	219	5	18204	48	PTPRZ1,NFIA,CLU,QKI,GLI3
2.868e-04	-8.16	cell periphery	cellular component	GO:0071944	6020	28	19108	50	PREX2,PTPRZ1,ZNRF3,SLC1A3,MERTK,TRPM3,ATP1A2,GNA14,IGSF11,ATP10B,FOLH1,NKAIN3,APOE,RPE65,APC,PLCB4,FGFR2,LRIG1,GPC5,LSAMP,CLU,GRAMD1C,FNBP1,TNIK,ATP13A4,CTNND2,SLC1A2,ITPR2
3.023e-04	-8.10	cellular response to cocaine	biological process	GO:0071314	10	2	18204	48	SLC1A3,SLC1A2
3.126e-04	-8.07	developmental process	biological process	GO:0032502	5716	27	18204	48	PDLIM5,APOE,ZNRF3,APC,GLI3,DAAM2,PTPRZ1,MERTK,NFIA,CLU,QKI,RFX4,LSAMP,SLC1A3,SLC1A2,LRIG1,ARHGEF26,RPE65,SPAG16,TNIK,MSI2,ABLIM1,CTNND2,PREX2,ATP1A2,TRPS1,FGFR2
3.193e-04	-8.05	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	24	16828	48	TTC28,CTNND2,SLC1A3,TRPM3,GLI3,APC,FOLH1,PDLIM5,CLU,QKI,RFX4,TRPS1,ZNRF3,ABLIM1,GLIS3,PLCB4,ATP1A2,FGFR2,PTPRZ1,DAAM2,PREX2,SPAG16,RPE65,LUZP2
3.193e-04	-8.05	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	24	16828	48	QKI,ZNRF3,RFX4,GLI3,TRPM3,SLC1A3,CLU,FOLH1,DAAM2,SPAG16,RPE65,FGFR2,ATP1A2,PTPRZ1,TRPS1,ABLIM1,CTNND2,TTC28,APC,PDLIM5,PREX2,LUZP2,GLIS3,PLCB4
3.251e-04	-8.03	synapse	cellular component	GO:0045202	1473	12	19108	50	SLC1A3,CLU,QKI,FGFR2,PTPRZ1,SLC1A2,APOE,ATP1A2,TNIK,PDLIM5,CTNND2,IGSF11
3.571e-04	-7.94	Glutamatergic synapse	KEGG pathways	hsa04724	114	4	7161	22	SLC1A3,PLCB4,ITPR2,SLC1A2
3.571e-04	-7.94	Glutamatergic synapse	KEGG pathways	ko04724	114	4	7161	22	SLC1A2,ITPR2,PLCB4,SLC1A3
3.636e-04	-7.92	platelet dense tubular network	cellular component	GO:0031094	11	2	19108	50	IRAG1,ITPR2
3.688e-04	-7.91	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	48	SLC1A2,SLC1A3
3.688e-04	-7.91	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	48	SLC1A3,SLC1A2
3.879e-04	-7.85	lipid transfer activity	molecular function	GO:0120013	56	3	18094	46	PITPNC1,APOE,GRAMD1C
3.923e-04	-7.84	cell junction	cellular component	GO:0030054	2224	15	19108	50	QKI,CLU,SLC1A3,FGFR2,PTPRZ1,APC,APOE,SLC1A2,PDLIM5,IGSF11,CTNND2,NFIA,TNIK,PLEKHA7,ATP1A2
3.957e-04	-7.83	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	23	16828	48	PREX2,LUZP2,GLIS3,NFIA,TRPS1,PLEKHA7,CTNND2,TTC28,APOE,APC,PDLIM5,SPAG16,MAML2,NPAS3,FGFR2,PTPRZ1,ZNRF3,MERTK,GLI3,TRPM3,SLC1A3,CLU,FOLH1
4.080e-04	-7.80	anatomical structure morphogenesis	biological process	GO:0009653	2225	15	18204	48	CLU,NFIA,PTPRZ1,QKI,ARHGEF26,LRIG1,SLC1A3,FGFR2,APOE,TNIK,PREX2,CTNND2,GLI3,APC,ABLIM1
4.099e-04	-7.80	intermembrane lipid transfer	biological process	GO:0120009	55	3	18204	48	GRAMD1C,APOE,PITPNC1
4.203e-04	-7.77	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	2	19454	50	CLU,APOE
4.246e-04	-7.76	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	28	16828	48	FGFR2,ATP1A2,PTPRZ1,MAML2,NPAS3,NKAIN3,GPC5,LRIG1,CLU,FOLH1,LSAMP,GLI3,SLC1A3,TRPM3,MERTK,ZNRF3,CDC14A,ATP13A4,PLCB4,LUZP2,ATP10B,APC,GNA14,ARHGEF26,CTNND2,ITPR2,PLEKHA7,TRPS1
4.246e-04	-7.76	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	28	16828	48	MERTK,ZNRF3,FOLH1,CLU,SLC1A3,TRPM3,GLI3,LSAMP,NKAIN3,LRIG1,GPC5,PTPRZ1,ATP1A2,FGFR2,NPAS3,MAML2,PLEKHA7,ITPR2,TRPS1,ARHGEF26,APC,GNA14,CTNND2,LUZP2,ATP10B,CDC14A,PLCB4,ATP13A4
4.278e-04	-7.76	lipid localization	biological process	GO:0010876	374	6	18204	48	GRAMD1C,CLU,APOE,ATP10B,PITPNC1,GULP1
4.301e-04	-7.75	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	50	ABLIM1,TNIK,SLC1A3,FGFR2,APC,FNBP1,PLEKHA7,MSI2
4.304e-04	-7.75	cell development	biological process	GO:0048468	2236	15	18204	48	CTNND2,GLI3,PREX2,TNIK,MSI2,APOE,PDLIM5,SPAG16,FGFR2,SLC1A3,ARHGEF26,QKI,MERTK,PTPRZ1,CLU
4.907e-04	-7.62	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	12	16828	48	MAML2,SPAG16,DAAM2,GPC5,LUZP2,IGSF11,TRPM3,PDLIM5,FOLH1,APC,GNA14,PLEKHA7
5.149e-04	-7.57	parietal_lobe	COSMIC cancer mutations	parietal_lobe	55	3	16828	48	QKI,FOLH1,FGFR2
5.163e-04	-7.57	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	2	16828	48	PREX2,APC
5.213e-04	-7.56	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	2	18204	48	APOE,CLU
5.271e-04	-7.55	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	23	16828	48	PLEKHA7,TRPS1,NFIA,PDLIM5,APC,APOE,CTNND2,TTC28,LUZP2,PREX2,GLIS3,MERTK,ZNRF3,CLU,FOLH1,GLI3,SLC1A3,TRPM3,SPAG16,PTPRZ1,FGFR2,NPAS3,MAML2
5.577e-04	-7.49	negative regulation of canonical Wnt signaling pathway	biological process	GO:0090090	144	4	18204	48	APOE,GLI3,APC,ZNRF3
5.643e-04	-7.48	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	46	SLC1A2,SLC1A3
5.679e-04	-7.47	neurogenesis	biological process	GO:0022008	1334	11	18204	48	CLU,NFIA,PTPRZ1,QKI,SLC1A3,FGFR2,APOE,TNIK,PREX2,GLI3,CTNND2
5.776e-04	-7.46	C9 (complement C9)	protein interactions	735	14	2	19454	50	APOE,CLU
5.776e-04	-7.46	HOXC6 (homeobox C6)	protein interactions	3223	14	2	19454	50	APC,FGFR2
6.091e-04	-7.40	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	2	16828	48	PREX2,APC
6.091e-04	-7.40	bone-maxilla-other-ameloblastoma	COSMIC cancer mutations	bone-maxilla-other-ameloblastoma	13	2	16828	48	FGFR2,APC
6.159e-04	-7.39	MAPT (microtubule associated protein tau)	protein interactions	4137	948	9	19454	50	SLC1A3,TNIK,LSAMP,CLU,SLC1A2,ABLIM1,APOE,CTNND2,ATP1A2
6.501e-04	-7.34	phosphatidylglycerol binding	molecular function	GO:1901611	15	2	18094	46	PITPNC1,RPE65
6.543e-04	-7.33	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	30	16828	48	PLCB4,GLIS3,ATP13A4,GRAMD1C,PREX2,ATP10B,TTC28,CTNND2,ARHGEF26,APC,GNA14,TRPS1,FNBP1,ABLIM1,PLEKHA7,ITPR2,MAML2,NPAS3,PTPRZ1,ATP1A2,FGFR2,DAAM2,GPC5,TNIK,RPE65,TRPM3,PITPNC1,GLI3,FOLH1,MERTK
6.662e-04	-7.31	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	21	16828	48	QKI,TRPS1,ITPR2,MERTK,PLEKHA7,CTNND2,PITPNC1,GLI3,APC,GNA14,DAAM2,TNIK,LRIG1,PREX2,SPAG16,MAML2,PLCB4,MSI2,FGFR2,PTPRZ1,CDC14A
6.818e-04	-7.29	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	5	16828	48	GRAMD1C,PLCB4,NPAS3,NFIA,GPC5
6.818e-04	-7.29	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	5	16828	48	GPC5,NFIA,NPAS3,PLCB4,GRAMD1C
6.998e-04	-7.26	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	9	19454	50	ABLIM1,CDC14A,PDLIM5,APC,PLEKHA7,PITPNC1,TTC28,FGFR2,MERTK
7.306e-04	-7.22	RNF43 (ring finger protein 43)	protein interactions	54894	424	6	19454	50	PLEKHA7,GLI3,APC,ABLIM1,QKI,TTC28
7.516e-04	-7.19	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	3	10285	32	ATP1A2,ATP10B,ATP13A4
7.639e-04	-7.18	gliogenesis	biological process	GO:0042063	275	5	18204	48	QKI,GLI3,NFIA,CLU,PTPRZ1
7.713e-04	-7.17	transporter activity	molecular function	GO:0005215	1211	10	18094	46	ATP10B,ATP13A4,TRPM3,GRAMD1C,SLC1A3,SLC1A2,ITPR2,APOE,ATP1A2,PITPNC1
7.979e-04	-7.13	locomotory exploration behavior	biological process	GO:0035641	16	2	18204	48	ATP1A2,APOE
8.069e-04	-7.12	chest	COSMIC cancer mutations	chest	147	4	16828	48	PLCB4,PREX2,APC,FGFR2
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	GRAMD1C,LSAMP
8.157e-04	-7.11	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	9	16828	48	ITPR2,ABLIM1,LRIG1,ATP1A2,FGFR2,APC,PTPRZ1,PDLIM5,NPAS3
8.258e-04	-7.10	lipid transporter activity	molecular function	GO:0005319	166	4	18094	46	APOE,PITPNC1,GRAMD1C,ATP10B
8.688e-04	-7.05	Wnt signaling pathway	biological process	GO:0016055	283	5	18204	48	DAAM2,CTNND2,APC,ZNRF3,TNIK
8.972e-04	-7.02	extraskeletal	COSMIC cancer mutations	extraskeletal	903	9	16828	48	ABLIM1,ITPR2,LRIG1,PTPRZ1,PDLIM5,APC,FGFR2,ATP1A2,NPAS3
9.003e-04	-7.01	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	7	19454	50	FGFR2,TNIK,ABLIM1,ARHGEF26,PLEKHA7,FNBP1,CLU
9.028e-04	-7.01	embryonic digestive tract morphogenesis	biological process	GO:0048557	17	2	18204	48	GLI3,FGFR2
9.028e-04	-7.01	reverse cholesterol transport	biological process	GO:0043691	17	2	18204	48	CLU,APOE
9.028e-04	-7.01	specification of animal organ identity	biological process	GO:0010092	17	2	18204	48	GLI3,FGFR2
9.028e-04	-7.01	regulation of amyloid fibril formation	biological process	GO:1905906	17	2	18204	48	CLU,APOE
9.320e-04	-6.98	bone-mandible-other-ameloblastoma	COSMIC cancer mutations	bone-mandible-other-ameloblastoma	16	2	16828	48	APC,FGFR2
9.320e-04	-6.98	ameloblastoma	COSMIC cancer mutations	ameloblastoma	16	2	16828	48	APC,FGFR2
9.427e-04	-6.97	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	2	18094	46	PITPNC1,ATP10B
9.427e-04	-6.97	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	46	SLC1A2,SLC1A3
9.780e-04	-6.93	sterol transport	biological process	GO:0015918	74	3	18204	48	GRAMD1C,CLU,APOE
9.906e-04	-6.92	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	7	16828	48	MAML2,PLCB4,FGFR2,APC,PDLIM5,ATP10B,TNIK
1.025e-03	-6.88	plasma membrane bounded cell projection assembly	biological process	GO:0120031	442	6	18204	48	ARHGEF26,ABLIM1,CDC14A,SPAG16,RFX4,TNIK
1.037e-03	-6.87	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	6	18204	48	SLC1A3,PREX2,CTNND2,GLI3,FGFR2,PTPRZ1
1.043e-03	-6.87	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	12	16828	48	GNA14,APC,PDLIM5,FOLH1,TRPM3,PLEKHA7,MAML2,IGSF11,LUZP2,GPC5,DAAM2,SPAG16
1.049e-03	-6.86	HAD_sf	interpro domains	IPR023214	74	3	18521	50	ATP13A4,ATP1A2,ATP10B
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP1A2,ATP13A4
1.071e-03	-6.84	arm	COSMIC cancer mutations	arm	1331	11	16828	48	LUZP2,NPAS3,PLCB4,FGFR2,ATP1A2,GRAMD1C,CDC14A,TRPS1,MERTK,TRPM3,APC
1.076e-03	-6.83	large_intestine-rectum	COSMIC cancer mutations	large_intestine-rectum	569	7	16828	48	GLI3,APC,FGFR2,DAAM2,TRPS1,SPAG16,PLEKHA7
1.080e-03	-6.83	prostate	COSMIC cancer mutations	prostate	13883	47	16828	48	CLU,LSAMP,SLC1A3,PTPRZ1,FGFR2,MAML2,IGSF11,LRIG1,TNIK,PDLIM5,GNA14,APC,NFIA,MSI2,ATP13A4,GLIS3,LUZP2,PREX2,FOLH1,GLI3,TRPM3,PITPNC1,MERTK,ZNRF3,RFX4,QKI,ATP1A2,NPAS3,NKAIN3,RPE65,SPAG16,GPC5,DAAM2,ARHGEF26,APOE,CTNND2,TTC28,PLEKHA7,ABLIM1,ITPR2,TRPS1,FNBP1,GULP1,GRAMD1C,PLCB4,SLC1A2,ATP10B
1.105e-03	-6.81	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	49	ATP1A2,ATP13A4
1.113e-03	-6.80	behavior	biological process	GO:0007610	619	7	18204	48	PREX2,GLI3,ATP1A2,SLC1A3,SLC1A2,APOE,PTPRZ1
1.131e-03	-6.78	regulation of amyloid-beta clearance	biological process	GO:1900221	19	2	18204	48	APOE,CLU
1.178e-03	-6.74	parotid	COSMIC cancer mutations	parotid	578	7	16828	48	TNIK,ATP10B,PLCB4,MAML2,PDLIM5,FGFR2,APC
1.182e-03	-6.74	regulation of glial cell differentiation	biological process	GO:0045685	79	3	18204	48	PTPRZ1,QKI,DAAM2
1.190e-03	-6.73	cell projection assembly	biological process	GO:0030031	455	6	18204	48	ABLIM1,CDC14A,ARHGEF26,RFX4,TNIK,SPAG16
1.194e-03	-6.73	PDLIM2 (PDZ and LIM domain 2)	protein interactions	64236	20	2	19454	50	FGFR2,APC
1.204e-03	-6.72	negative regulation of Wnt signaling pathway	biological process	GO:0030178	177	4	18204	48	ZNRF3,APC,APOE,GLI3
1.221e-03	-6.71	HAD-like_sf	interpro domains	IPR036412	78	3	18521	50	ATP10B,ATP1A2,ATP13A4
1.225e-03	-6.70	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	47	16828	48	ATP1A2,NPAS3,RPE65,NKAIN3,DAAM2,GPC5,SPAG16,FOLH1,PITPNC1,TRPM3,GLI3,MERTK,QKI,ZNRF3,GRAMD1C,GULP1,CDC14A,SLC1A2,PLCB4,ATP10B,ARHGEF26,TTC28,CTNND2,APOE,ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1,FGFR2,PTPRZ1,MAML2,IGSF11,TNIK,LRIG1,CLU,SLC1A3,LSAMP,ATP13A4,GLIS3,MSI2,LUZP2,PREX2,GNA14,APC,PDLIM5,NFIA
1.225e-03	-6.70	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	47	16828	48	CLU,LSAMP,SLC1A3,PTPRZ1,FGFR2,MAML2,IGSF11,LRIG1,TNIK,PDLIM5,APC,GNA14,NFIA,MSI2,GLIS3,ATP13A4,LUZP2,PREX2,FOLH1,GLI3,TRPM3,PITPNC1,MERTK,ZNRF3,QKI,ATP1A2,NPAS3,NKAIN3,RPE65,SPAG16,GPC5,DAAM2,ARHGEF26,APOE,CTNND2,TTC28,PLEKHA7,ABLIM1,ITPR2,TRPS1,FNBP1,CDC14A,GULP1,GRAMD1C,PLCB4,SLC1A2,ATP10B
1.226e-03	-6.70	multicellular organismal process	biological process	GO:0032501	6177	27	18204	48	MSI2,TNIK,SPAG16,CDC14A,CTNND2,ABLIM1,PREX2,TRPS1,FGFR2,ATP1A2,APOE,PDLIM5,ZNRF3,APC,GLI3,DAAM2,QKI,LSAMP,RFX4,PTPRZ1,MERTK,CLU,NFIA,RPE65,SLC1A3,LRIG1,SLC1A2
1.245e-03	-6.69	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	23	16828	48	CDC14A,PLCB4,MSI2,ATP13A4,PREX2,APC,GNA14,CTNND2,PLEKHA7,ITPR2,TRPS1,PTPRZ1,FGFR2,MAML2,LRIG1,DAAM2,TNIK,CLU,PITPNC1,GLI3,MERTK,ZNRF3,QKI
1.255e-03	-6.68	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	48	SLC1A3,SLC1A2
1.288e-03	-6.65	uveal_tract	COSMIC cancer mutations	uveal_tract	587	7	16828	48	APC,FGFR2,TRPM3,PLCB4,CTNND2,TTC28,PREX2
1.314e-03	-6.64	human chr22q12.1	chromosome location	human chr22q12.1	28	2	26134	50	TTC28,ZNRF3
1.316e-03	-6.63	cellular response to organic cyclic compound	biological process	GO:0071407	464	6	18204	48	ATP1A2,GRAMD1C,SLC1A3,SLC1A2,GNA14,ITPR2
1.337e-03	-6.62	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	48	16828	48	GLIS3,ATP13A4,MSI2,LUZP2,PREX2,GNA14,APC,PDLIM5,NFIA,FGFR2,PTPRZ1,MAML2,IGSF11,TNIK,LRIG1,CLU,LSAMP,SLC1A3,GULP1,GRAMD1C,CDC14A,SLC1A2,PLCB4,ATP10B,ARHGEF26,CTNND2,TTC28,APOE,ITPR2,PLEKHA7,ABLIM1,FNBP1,TRPS1,ATP1A2,NPAS3,NKAIN3,RPE65,GPC5,DAAM2,SPAG16,FOLH1,GLI3,TRPM3,PITPNC1,MERTK,QKI,ZNRF3,RFX4
1.368e-03	-6.59	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	3	14470	43	ATP13A4,ATP1A2,ATP10B
1.374e-03	-6.59	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	4	7161	22	PLCB4,IRAG1,ITPR2,ATP1A2
1.374e-03	-6.59	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	4	7161	22	ATP1A2,IRAG1,ITPR2,PLCB4
1.417e-03	-6.56	Thyroid hormone synthesis	KEGG pathways	ko04918	74	3	7161	22	PLCB4,ATP1A2,ITPR2
1.417e-03	-6.56	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	3	7161	22	PLCB4,ITPR2,ATP1A2
1.446e-03	-6.54	appendage development	biological process	GO:0048736	186	4	18204	48	GLI3,FGFR2,ZNRF3,NFIA
1.446e-03	-6.54	limb development	biological process	GO:0060173	186	4	18204	48	ZNRF3,FGFR2,GLI3,NFIA
1.460e-03	-6.53	oligodendrocyte differentiation	biological process	GO:0048709	85	3	18204	48	PTPRZ1,CLU,GLI3
1.468e-03	-6.52	adherens junction	cellular component	GO:0005912	188	4	19108	50	PLEKHA7,APC,CTNND2,PDLIM5
1.473e-03	-6.52	Gastric acid secretion	KEGG pathways	hsa04971	75	3	7161	22	PLCB4,ATP1A2,ITPR2
1.473e-03	-6.52	Gastric acid secretion	KEGG pathways	ko04971	75	3	7161	22	PLCB4,ITPR2,ATP1A2
1.504e-03	-6.50	abdomen	COSMIC cancer mutations	abdomen	603	7	16828	48	PREX2,LRIG1,ITPR2,CTNND2,PLCB4,FGFR2,APC
1.507e-03	-6.50	lower_leg	COSMIC cancer mutations	lower_leg	174	4	16828	48	PREX2,PLCB4,FGFR2,APC
1.510e-03	-6.50	transport across blood-brain barrier	biological process	GO:0150104	86	3	18204	48	SLC1A2,SLC1A3,ATP1A2
1.510e-03	-6.50	vascular transport	biological process	GO:0010232	86	3	18204	48	SLC1A2,SLC1A3,ATP1A2
1.521e-03	-6.49	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	48	ATP1A2,SLC1A3
1.546e-03	-6.47	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	46	SLC1A2,SLC1A3
1.546e-03	-6.47	cholesterol transfer activity	molecular function	GO:0120020	23	2	18094	46	GRAMD1C,APOE
1.547e-03	-6.47	eye	COSMIC cancer mutations	eye	606	7	16828	48	PREX2,PLCB4,TRPM3,TTC28,CTNND2,APC,FGFR2
1.550e-03	-6.47	Cation_ATPase_N	smart domains	SM00831	16	2	9717	36	ATP13A4,ATP1A2
1.582e-03	-6.45	Rbm38 (RNA binding motif protein 38)	protein interactions	56190	23	2	19454	50	MSI2,QKI
1.663e-03	-6.40	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	22	16828	48	PTPRZ1,CDC14A,GRAMD1C,FGFR2,GULP1,ATP13A4,RPE65,IGSF11,LRIG1,PREX2,DAAM2,TNIK,APC,TRPM3,GLI3,TTC28,CTNND2,PLEKHA7,ITPR2,TRPS1,RFX4,NFIA
1.665e-03	-6.40	neuron projection morphogenesis	biological process	GO:0048812	486	6	18204	48	PTPRZ1,CTNND2,GLI3,FGFR2,TNIK,PREX2
1.667e-03	-6.40	cell fate specification	biological process	GO:0001708	89	3	18204	48	NFIA,GLI3,APC
1.676e-03	-6.39	neuron development	biological process	GO:0048666	859	8	18204	48	PTPRZ1,TNIK,APOE,SLC1A3,CTNND2,FGFR2,GLI3,PREX2
1.684e-03	-6.39	sterol transfer activity	molecular function	GO:0120015	24	2	18094	46	APOE,GRAMD1C
1.684e-03	-6.39	low-density lipoprotein particle receptor binding	molecular function	GO:0050750	24	2	18094	46	CLU,APOE
1.684e-03	-6.39	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	46	ATP1A2,ATP13A4
1.684e-03	-6.39	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	46	ATP13A4,ATP1A2
1.754e-03	-6.35	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	6	18204	48	PTPRZ1,TNIK,FGFR2,GLI3,CTNND2,PREX2
1.775e-03	-6.33	endometrium-carcinoma-carcinosarcoma-malignant_mesodermal_mixed_tumour	COSMIC cancer mutations	endometrium-carcinoma-carcinosarcoma-malignant_mesodermal_mixed_tumour	22	2	16828	48	FGFR2,APC
1.826e-03	-6.31	neuron differentiation	biological process	GO:0030182	1081	9	18204	48	NFIA,PTPRZ1,APOE,TNIK,SLC1A3,PREX2,FGFR2,CTNND2,GLI3
1.839e-03	-6.30	back	COSMIC cancer mutations	back	310	5	16828	48	PREX2,PLCB4,TNIK,FGFR2,ATP1A2
1.846e-03	-6.29	cell projection morphogenesis	biological process	GO:0048858	496	6	18204	48	PTPRZ1,PREX2,TNIK,GLI3,FGFR2,CTNND2
1.891e-03	-6.27	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	48	ATP1A2,NPAS3,NKAIN3,RPE65,DAAM2,GPC5,SPAG16,FOLH1,GLI3,TRPM3,PITPNC1,MERTK,QKI,ZNRF3,RFX4,GULP1,GRAMD1C,CDC14A,SLC1A2,PLCB4,ATP10B,ARHGEF26,CTNND2,TTC28,APOE,ITPR2,PLEKHA7,ABLIM1,FNBP1,TRPS1,FGFR2,PTPRZ1,MAML2,IGSF11,TNIK,LRIG1,CLU,LSAMP,SLC1A3,ATP13A4,GLIS3,MSI2,LUZP2,PREX2,APC,GNA14,PDLIM5,NFIA
1.903e-03	-6.26	pleura	COSMIC cancer mutations	pleura	4914	24	16828	48	TRPS1,ITPR2,PLEKHA7,CTNND2,GNA14,ATP10B,PREX2,ATP13A4,MSI2,PLCB4,GRAMD1C,CDC14A,QKI,ZNRF3,MERTK,GLI3,PITPNC1,CLU,TNIK,DAAM2,LRIG1,MAML2,FGFR2,PTPRZ1
1.913e-03	-6.26	human chr20p12.3-p12.2	chromosome location	human chr20p12.3-p12.2	1	1	26134	50	PLCB4
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr2q32.1-q32.2	chromosome location	human chr2q32.1-q32.2	1	1	26134	50	GULP1
1.913e-03	-6.26	human chr11p15.2-p15.1	chromosome location	human chr11p15.2-p15.1	1	1	26134	50	PLEKHA7
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.940e-03	-6.25	skin-face-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-face-malignant_melanoma-lentigo_maligna	23	2	16828	48	FGFR2,PREX2
1.965e-03	-6.23	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	48	SLC1A2,SLC1A3
1.987e-03	-6.22	LIN7C (lin-7 homolog C, crumbs cell polarity complex component)	protein interactions	55327	97	3	19454	50	ABLIM1,ARHGEF26,APC
2.002e-03	-6.21	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	7	16828	48	MERTK,RPE65,NFIA,PREX2,APC,PTPRZ1,PLCB4
2.024e-03	-6.20	import into cell	biological process	GO:0098657	687	7	18204	48	MERTK,FNBP1,GULP1,APOE,ATP1A2,SLC1A2,SLC1A3
2.035e-03	-6.20	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	10	16828	48	ATP13A4,CTNND2,PLCB4,TRPM3,ATP1A2,APC,GPC5,SPAG16,PREX2,PLEKHA7
2.046e-03	-6.19	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	40	16828	48	ATP1A2,PTPRZ1,MAML2,NPAS3,IGSF11,RPE65,NKAIN3,GPC5,DAAM2,TNIK,LRIG1,SPAG16,FOLH1,CLU,TRPM3,SLC1A3,GLI3,LSAMP,MERTK,QKI,RFX4,GRAMD1C,GULP1,CDC14A,SLC1A2,ATP13A4,PLCB4,LUZP2,ATP10B,PREX2,GNA14,APC,PDLIM5,ARHGEF26,TTC28,CTNND2,ITPR2,ABLIM1,PLEKHA7,TRPS1
2.095e-03	-6.17	high-density lipoprotein particle	cellular component	GO:0034364	26	2	19108	50	APOE,CLU
2.107e-03	-6.16	TNKS (tankyrase)	protein interactions	8658	99	3	19454	50	APC,FNBP1,TNIK
2.113e-03	-6.16	soft_tissue-fibrous_tissue_and_uncertain_origin-endometrial_stromal_sarcoma	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-endometrial_stromal_sarcoma	24	2	16828	48	FGFR2,APC
2.113e-03	-6.16	endometrial_stromal_sarcoma	COSMIC cancer mutations	endometrial_stromal_sarcoma	24	2	16828	48	FGFR2,APC
2.123e-03	-6.16	cell-cell junction	cellular component	GO:0005911	513	6	19108	50	IGSF11,CTNND2,PDLIM5,APC,PLEKHA7,ATP1A2
2.125e-03	-6.15	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	48	SLC1A2,SLC1A3
2.126e-03	-6.15	neuron projection development	biological process	GO:0031175	693	7	18204	48	FGFR2,CTNND2,GLI3,PREX2,PTPRZ1,TNIK,APOE
2.132e-03	-6.15	nerve development	biological process	GO:0021675	97	3	18204	48	LRIG1,SLC1A3,GLI3
2.136e-03	-6.15	neck	COSMIC cancer mutations	neck	1231	10	16828	48	PLEKHA7,SPAG16,PREX2,GPC5,ATP1A2,APC,PLCB4,TRPM3,ATP13A4,CTNND2
2.181e-03	-6.13	MBNL2 (muscleblind like splicing regulator 2)	protein interactions	10150	27	2	19454	50	QKI,MSI2
2.260e-03	-6.09	phospholipid transport	biological process	GO:0015914	99	3	18204	48	ATP10B,APOE,PITPNC1
2.284e-03	-6.08	-	gene3d domains	3.50.30.30	24	2	14470	43	FOLH1,ZNRF3
2.291e-03	-6.08	regulation of non-canonical Wnt signaling pathway	biological process	GO:2000050	27	2	18204	48	ZNRF3,DAAM2
2.291e-03	-6.08	cell proliferation in forebrain	biological process	GO:0021846	27	2	18204	48	FGFR2,GLI3
2.424e-03	-6.02	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	3	19454	50	TTC28,ABLIM1,CLU
2.457e-03	-6.01	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	46	SLC1A2,SLC1A3
2.457e-03	-6.01	lipoprotein particle receptor binding	molecular function	GO:0070325	29	2	18094	46	APOE,CLU
2.463e-03	-6.01	positive regulation of oligodendrocyte differentiation	biological process	GO:0048714	28	2	18204	48	QKI,PTPRZ1
2.463e-03	-6.01	glial cell proliferation	biological process	GO:0014009	28	2	18204	48	NFIA,CLU
2.476e-03	-6.00	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	38	16828	48	ATP10B,PREX2,GRAMD1C,GULP1,CDC14A,ATP13A4,PLCB4,MSI2,ITPR2,ABLIM1,PLEKHA7,NFIA,TRPS1,APC,GNA14,CTNND2,IGSF11,RPE65,NKAIN3,DAAM2,GPC5,TNIK,LRIG1,SPAG16,ATP1A2,FGFR2,PTPRZ1,MAML2,NPAS3,MERTK,QKI,RFX4,ZNRF3,FOLH1,CLU,TRPM3,PITPNC1,GLI3
2.480e-03	-6.00	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	32	SLC1A3,SLC1A2
2.487e-03	-6.00	Salivary secretion	KEGG pathways	hsa04970	90	3	7161	22	ITPR2,ATP1A2,PLCB4
2.487e-03	-6.00	Salivary secretion	KEGG pathways	ko04970	90	3	7161	22	PLCB4,ATP1A2,ITPR2
2.495e-03	-5.99	Arm	pfam domains	PF00514	27	2	17795	49	CTNND2,APC
2.507e-03	-5.99	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	38	16828	48	ITPR2,PLEKHA7,ABLIM1,NFIA,TRPS1,APC,GNA14,CTNND2,ATP10B,PREX2,GULP1,GRAMD1C,CDC14A,ATP13A4,MSI2,PLCB4,MERTK,QKI,ZNRF3,RFX4,CLU,FOLH1,GLI3,TRPM3,PITPNC1,IGSF11,NKAIN3,RPE65,TNIK,DAAM2,GPC5,SPAG16,LRIG1,FGFR2,ATP1A2,PTPRZ1,MAML2,NPAS3
2.514e-03	-5.99	CNTF (ciliary neurotrophic factor)	protein interactions	1270	29	2	19454	50	GULP1,APOE
2.537e-03	-5.98	beta-catenin binding	molecular function	GO:0008013	107	3	18094	46	GLI3,APC,CTNND2
2.542e-03	-5.97	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	molecular function	GO:0052885	1	1	18094	46	RPE65
2.542e-03	-5.97	tetrahydrofolyl-poly(glutamate) polymer binding	molecular function	GO:1904493	1	1	18094	46	FOLH1
2.542e-03	-5.97	Ac-Asp-Glu binding	molecular function	GO:1904492	1	1	18094	46	FOLH1
2.542e-03	-5.97	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity	molecular function	GO:0052884	1	1	18094	46	RPE65
2.542e-03	-5.97	ethanolamine-phosphate phospho-lyase activity	molecular function	GO:0050459	1	1	18094	46	ETNPPL
2.542e-03	-5.97	internal N(7)-methylguanine-containing RNA reader activity	molecular function	GO:0160089	1	1	18094	46	QKI
2.542e-03	-5.97	metal chelating activity	molecular function	GO:0046911	1	1	18094	46	APOE
2.570e-03	-5.96	SLC27A1 (solute carrier family 27 member 1)	protein interactions	100037269	1	1	19454	50	RPE65
2.570e-03	-5.96	Ctnna1 (catenin alpha 1)	protein interactions	12385	1	1	19454	50	APC
2.570e-03	-5.96	Usp7 (ubiquitin specific peptidase 7)	protein interactions	252870	1	1	19454	50	APC
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.580e-03	-5.96	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	10	16828	48	TNIK,TRPS1,LUZP2,ABLIM1,CTNND2,TTC28,ATP13A4,GLI3,PLCB4,FOLH1
2.580e-03	-5.96	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	10	16828	48	FOLH1,PLCB4,GLI3,ATP13A4,TTC28,CTNND2,ABLIM1,LUZP2,TRPS1,TNIK
2.617e-03	-5.95	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	50	CLU
2.637e-03	-5.94	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	48	CLU
2.637e-03	-5.94	lambdoid suture morphogenesis	biological process	GO:0060366	1	1	18204	48	GLI3
2.637e-03	-5.94	olfactory cortex development	biological process	GO:0021989	1	1	18204	48	ATP1A2
2.637e-03	-5.94	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow	biological process	GO:0035604	1	1	18204	48	FGFR2
2.637e-03	-5.94	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	48	CLU
2.637e-03	-5.94	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	48	APOE
2.637e-03	-5.94	xanthophyll biosynthetic process	biological process	GO:0016123	1	1	18204	48	RPE65
2.637e-03	-5.94	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	48	APOE
2.637e-03	-5.94	anterior semicircular canal development	biological process	GO:0060873	1	1	18204	48	GLI3
2.637e-03	-5.94	lateral semicircular canal development	biological process	GO:0060875	1	1	18204	48	GLI3
2.637e-03	-5.94	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	48	APOE
2.637e-03	-5.94	sagittal suture morphogenesis	biological process	GO:0060367	1	1	18204	48	GLI3
2.637e-03	-5.94	lateral ganglionic eminence cell proliferation	biological process	GO:0022018	1	1	18204	48	GLI3
2.637e-03	-5.94	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	48	APOE
2.637e-03	-5.94	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell	biological process	GO:0035602	1	1	18204	48	FGFR2
2.637e-03	-5.94	fibroblast growth factor receptor signaling pathway involved in hemopoiesis	biological process	GO:0035603	1	1	18204	48	FGFR2
2.637e-03	-5.94	phospholipase C-activating endothelin receptor signaling pathway	biological process	GO:0160135	1	1	18204	48	PLCB4
2.637e-03	-5.94	zeaxanthin biosynthetic process	biological process	GO:1901827	1	1	18204	48	RPE65
2.637e-03	-5.94	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	48	APOE
2.637e-03	-5.94	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	48	ATP1A2
2.637e-03	-5.94	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	48	APOE
2.637e-03	-5.94	carotenoid biosynthetic process	biological process	GO:0016117	1	1	18204	48	RPE65
2.637e-03	-5.94	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	biological process	GO:0060595	1	1	18204	48	FGFR2
2.637e-03	-5.94	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	48	APOE
2.637e-03	-5.94	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	48	APOE
2.637e-03	-5.94	tetraterpenoid biosynthetic process	biological process	GO:0016109	1	1	18204	48	RPE65
2.637e-03	-5.94	subpallium cell proliferation in forebrain	biological process	GO:0022012	1	1	18204	48	GLI3
2.641e-03	-5.94	negative regulation of amyloid-beta formation	biological process	GO:1902430	29	2	18204	48	APOE,CLU
2.641e-03	-5.94	cGMP-mediated signaling	biological process	GO:0019934	29	2	18204	48	APOE,IRAG1
2.661e-03	-5.93	cell projection	cellular component	GO:0042995	2398	14	19108	50	SLC1A3,CLU,MERTK,ABLIM1,APC,CDC14A,ARHGEF26,SLC1A2,GLI3,SPAG16,APOE,ATP1A2,CTNND2,PDLIM5
2.671e-03	-5.93	neural precursor cell proliferation	biological process	GO:0061351	105	3	18204	48	NFIA,FGFR2,GLI3
2.700e-03	-5.91	APC_15aa_rpt	interpro domains	IPR009240	1	1	18521	50	APC
2.700e-03	-5.91	Luzp2	interpro domains	IPR026718	1	1	18521	50	LUZP2
2.700e-03	-5.91	FNBP1_F-BAR	interpro domains	IPR037449	1	1	18521	50	FNBP1
2.700e-03	-5.91	CHAT_dom	interpro domains	IPR024983	1	1	18521	50	TTC28
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	STAR_dimer	interpro domains	IPR032377	1	1	18521	50	QKI
2.700e-03	-5.91	FNBP1_SH3	interpro domains	IPR035492	1	1	18521	50	FNBP1
2.700e-03	-5.91	ZNRF3_Znf_RING	interpro domains	IPR045903	1	1	18521	50	ZNRF3
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.700e-03	-5.91	Quaking_NLS	interpro domains	IPR032367	1	1	18521	50	QKI
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	MAML2_TAD	interpro domains	IPR048452	1	1	18521	50	MAML2
2.700e-03	-5.91	EB1-bd	interpro domains	IPR009232	1	1	18521	50	APC
2.700e-03	-5.91	IGSF11	interpro domains	IPR042758	1	1	18521	50	IGSF11
2.749e-03	-5.90	trunk	COSMIC cancer mutations	trunk	3554	19	16828	48	ABLIM1,PLEKHA7,TRPS1,APC,SLC1A3,LSAMP,CTNND2,SPAG16,PREX2,ATP10B,PTPRZ1,ATP1A2,GRAMD1C,FGFR2,NPAS3,MAML2,PLCB4,GLIS3,ATP13A4
2.754e-03	-5.89	APC_15aa	pfam domains	PF05972	1	1	17795	49	APC
2.754e-03	-5.89	APC_u5	pfam domains	PF16630	1	1	17795	49	APC
2.754e-03	-5.89	EB1_binding	pfam domains	PF05937	1	1	17795	49	APC
2.754e-03	-5.89	CHAT	pfam domains	PF12770	1	1	17795	49	TTC28
2.754e-03	-5.89	STAR_dimer	pfam domains	PF16544	1	1	17795	49	QKI
2.754e-03	-5.89	APC_u14	pfam domains	PF16635	1	1	17795	49	APC
2.754e-03	-5.89	MAML2_TAD	pfam domains	PF20804	1	1	17795	49	MAML2
2.754e-03	-5.89	APC_u9	pfam domains	PF16633	1	1	17795	49	APC
2.754e-03	-5.89	APC_u13	pfam domains	PF16634	1	1	17795	49	APC
2.754e-03	-5.89	Quaking_NLS	pfam domains	PF16551	1	1	17795	49	QKI
2.754e-03	-5.89	APC_u15	pfam domains	PF16636	1	1	17795	49	APC
2.796e-03	-5.88	BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase)	protein interactions	8945	745	7	19454	50	GLI3,APC,PDLIM5,MSI2,CLU,ZNRF3,MERTK
2.825e-03	-5.87	L-glutamate import	biological process	GO:0051938	30	2	18204	48	SLC1A2,SLC1A3
2.863e-03	-5.86	DST (dystonin)	protein interactions	667	230	4	19454	50	TNIK,FGFR2,APC,ATP1A2
2.872e-03	-5.85	mandible	COSMIC cancer mutations	mandible	28	2	16828	48	FGFR2,APC
2.901e-03	-5.84	Pancreatic secretion	KEGG pathways	hsa04972	95	3	7161	22	ATP1A2,ITPR2,PLCB4
2.901e-03	-5.84	Pancreatic secretion	KEGG pathways	ko04972	95	3	7161	22	ATP1A2,ITPR2,PLCB4
2.917e-03	-5.84	generation of neurons	biological process	GO:0048699	1158	9	18204	48	SLC1A3,PREX2,CTNND2,GLI3,FGFR2,NFIA,PTPRZ1,APOE,TNIK
2.972e-03	-5.82	-	gene3d domains	1.20.5.4010	1	1	14470	43	QKI
2.986e-03	-5.81	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	27	16828	48	MERTK,GLI3,TRPM3,SLC1A3,IGSF11,NKAIN3,RPE65,DAAM2,SPAG16,LRIG1,FGFR2,ATP1A2,PTPRZ1,MAML2,NPAS3,ITPR2,PLEKHA7,ABLIM1,FNBP1,GNA14,APC,PDLIM5,CTNND2,ATP10B,PREX2,ATP13A4,GLIS3
3.015e-03	-5.80	negative regulation of amyloid precursor protein catabolic process	biological process	GO:1902992	31	2	18204	48	APOE,CLU
3.047e-03	-5.79	positive regulation of canonical Wnt signaling pathway	biological process	GO:0090263	110	3	18204	48	GPC5,DAAM2,FGFR2
3.057e-03	-5.79	IL24 (interleukin 24)	protein interactions	11009	32	2	19454	50	CLU,APC
3.111e-03	-5.77	Signaling by FGFR2 amplification mutants	REACTOME pathways	R-HSA-2023837	1	1	10285	32	FGFR2
3.111e-03	-5.77	APC truncation mutants are not K63 polyubiquitinated	REACTOME pathways	R-HSA-5467333	1	1	10285	32	APC
3.111e-03	-5.77	Signaling by FGFR2 fusions	REACTOME pathways	R-HSA-8853333	1	1	10285	32	FGFR2
3.145e-03	-5.76	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	47	16828	48	FOLH1,PITPNC1,TRPM3,GLI3,MERTK,QKI,RFX4,ZNRF3,ATP1A2,NPAS3,RPE65,NKAIN3,GPC5,DAAM2,SPAG16,ARHGEF26,TTC28,CTNND2,APOE,ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1,GRAMD1C,GULP1,CDC14A,SLC1A2,PLCB4,ATP10B,CLU,SLC1A3,LSAMP,FGFR2,PTPRZ1,MAML2,IGSF11,TNIK,LRIG1,APC,GNA14,PDLIM5,NFIA,ATP13A4,GLIS3,LUZP2,PREX2
3.168e-03	-5.75	cell body	cellular component	GO:0044297	556	6	19108	50	SLC1A2,SLC1A3,RPE65,APOE,ATP1A2,CTNND2
3.206e-03	-5.74	regulation of gliogenesis	biological process	GO:0014013	112	3	18204	48	PTPRZ1,QKI,DAAM2
3.211e-03	-5.74	transepithelial transport	biological process	GO:0070633	32	2	18204	48	SLC1A3,SLC1A2
3.249e-03	-5.73	VLDLR (very low density lipoprotein receptor)	protein interactions	7436	33	2	19454	50	APOE,CLU
3.253e-03	-5.73	extracellular matrix	cellular component	GO:0031012	559	6	19108	50	CLU,LRIG1,GPC5,PTPRZ1,FGFR2,APOE
3.259e-03	-5.73	caecum	COSMIC cancer mutations	caecum	14248	47	16828	48	NFIA,GNA14,APC,PDLIM5,PREX2,LUZP2,ATP13A4,GLIS3,SLC1A3,LSAMP,CLU,TNIK,LRIG1,IGSF11,MAML2,FGFR2,PTPRZ1,FNBP1,TRPS1,ITPR2,ABLIM1,PLEKHA7,TTC28,CTNND2,APOE,ARHGEF26,ATP10B,SLC1A2,PLCB4,GRAMD1C,GULP1,CDC14A,QKI,RFX4,ZNRF3,MERTK,TRPM3,PITPNC1,GLI3,FOLH1,DAAM2,GPC5,SPAG16,RPE65,NKAIN3,NPAS3,ATP1A2
3.282e-03	-5.72	external encapsulating structure	cellular component	GO:0030312	560	6	19108	50	CLU,GPC5,LRIG1,APOE,FGFR2,PTPRZ1
3.282e-03	-5.72	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	49	ATP13A4,ATP1A2
3.294e-03	-5.72	skin-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-malignant_melanoma-acral_lentiginous	30	2	16828	48	PREX2,FGFR2
3.294e-03	-5.72	lentigo_maligna	COSMIC cancer mutations	lentigo_maligna	30	2	16828	48	FGFR2,PREX2
3.329e-03	-5.71	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	10	16828	48	TRPS1,MERTK,LUZP2,NPAS3,PLCB4,TRPM3,CDC14A,GRAMD1C,ATP1A2,APC
3.353e-03	-5.70	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	12	19454	50	NFIA,TRPS1,ABLIM1,PDLIM5,QKI,LUZP2,MSI2,FOLH1,ARHGEF26,GULP1,PLCB4,FNBP1
3.365e-03	-5.69	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	41	CLU
3.365e-03	-5.69	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	41	CLU
3.412e-03	-5.68	embryonic digestive tract development	biological process	GO:0048566	33	2	18204	48	GLI3,FGFR2
3.412e-03	-5.68	response to auditory stimulus	biological process	GO:0010996	33	2	18204	48	ATP1A2,SLC1A3
3.475e-03	-5.66	transport	biological process	GO:0006810	3615	18	18204	48	MERTK,CLU,QKI,FNBP1,SLC1A3,GRAMD1C,SLC1A2,ATP1A2,TRPM3,ITPR2,SPAG16,PITPNC1,APOE,ATP10B,PLCB4,GULP1,ATP13A4,GLI3
3.567e-03	-5.64	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	46	SLC1A3,SLC1A2
3.567e-03	-5.64	bone	COSMIC cancer mutations	bone	8157	33	16828	48	MERTK,QKI,SLC1A3,TRPM3,GLI3,LSAMP,IGSF11,RPE65,NKAIN3,DAAM2,GPC5,TNIK,SPAG16,LRIG1,ATP1A2,FGFR2,PTPRZ1,NPAS3,MAML2,ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1,APC,GNA14,PDLIM5,CTNND2,LUZP2,ATP10B,PREX2,ATP13A4,GLIS3
3.619e-03	-5.62	negative regulation of amide metabolic process	biological process	GO:0034249	34	2	18204	48	CLU,APOE
3.619e-03	-5.62	exploration behavior	biological process	GO:0035640	34	2	18204	48	ATP1A2,APOE
3.708e-03	-5.60	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	3	10285	32	GPC5,RPE65,APOE
3.814e-03	-5.57	Ion channel transport	REACTOME pathways	R-HSA-983712	209	4	10285	32	TRPM3,ATP1A2,ATP10B,ATP13A4
3.832e-03	-5.56	neuron fate specification	biological process	GO:0048665	35	2	18204	48	NFIA,GLI3
3.872e-03	-5.55	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	9	16828	48	ATP13A4,SLC1A2,GNA14,GULP1,APC,SPAG16,QKI,GPC5,LUZP2
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	IGSF11,LRIG1,FGFR2,LSAMP
3.976e-03	-5.53	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-cutaneous_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-cutaneous_T_cell_lymphoma	33	2	16828	48	FGFR2,APC
3.976e-03	-5.53	cutaneous_T_cell_lymphoma	COSMIC cancer mutations	cutaneous_T_cell_lymphoma	33	2	16828	48	FGFR2,APC
3.994e-03	-5.52	plasma lipoprotein particle	cellular component	GO:0034358	36	2	19108	50	APOE,CLU
3.994e-03	-5.52	lipoprotein particle	cellular component	GO:1990777	36	2	19108	50	APOE,CLU
4.023e-03	-5.52	lung-carcinoma	COSMIC cancer mutations	lung-carcinoma	4255	21	16828	48	PREX2,LRIG1,TNIK,DAAM2,CDC14A,PTPRZ1,FGFR2,MSI2,MAML2,PLCB4,PLEKHA7,MERTK,ITPR2,TRPS1,QKI,CLU,GNA14,APC,GLI3,PITPNC1,CTNND2
4.048e-03	-5.51	sensory organ development	biological process	GO:0007423	581	6	18204	48	LRIG1,MERTK,NFIA,GLI3,FGFR2,RPE65
4.052e-03	-5.51	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	42	16828	48	ATP1A2,FGFR2,PTPRZ1,MAML2,NPAS3,IGSF11,RPE65,DAAM2,GPC5,TNIK,LRIG1,SPAG16,FOLH1,PITPNC1,SLC1A3,TRPM3,GLI3,LSAMP,MERTK,QKI,RFX4,ZNRF3,GRAMD1C,GULP1,CDC14A,SLC1A2,GLIS3,ATP13A4,PLCB4,LUZP2,ATP10B,PREX2,APC,PDLIM5,TTC28,CTNND2,ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1,NFIA
4.093e-03	-5.50	cervix	COSMIC cancer mutations	cervix	11793	42	16828	48	CTNND2,TTC28,APC,PDLIM5,FNBP1,NFIA,TRPS1,ITPR2,PLEKHA7,ABLIM1,ATP13A4,SLC1A2,GLIS3,PLCB4,GULP1,GRAMD1C,CDC14A,ATP10B,PREX2,LUZP2,GLI3,LSAMP,TRPM3,PITPNC1,SLC1A3,FOLH1,QKI,ZNRF3,RFX4,MERTK,NPAS3,MAML2,FGFR2,ATP1A2,PTPRZ1,TNIK,DAAM2,GPC5,SPAG16,LRIG1,IGSF11,RPE65
4.102e-03	-5.50	Ig_sub	interpro domains	IPR003599	394	5	18521	50	LSAMP,FGFR2,MERTK,LRIG1,IGSF11
4.196e-03	-5.47	skin-chest-malignant_melanoma	COSMIC cancer mutations	skin-chest-malignant_melanoma	114	3	16828	48	PREX2,PLCB4,APC
4.217e-03	-5.47	central_nervous_system-parietal_lobe-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-parietal_lobe-glioma-astrocytoma_Grade_I	34	2	16828	48	FGFR2,QKI
4.217e-03	-5.47	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-anaplastic_large_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-anaplastic_large_cell_lymphoma	34	2	16828	48	FGFR2,APC
4.234e-03	-5.46	ARM_REPEAT	prosite domains	PS50176	29	2	12186	41	APC,CTNND2
4.258e-03	-5.46	PAX9 (paired box 9)	protein interactions	5083	127	3	19454	50	TRPS1,NFIA,QKI
4.282e-03	-5.45	forebrain development	biological process	GO:0030900	408	5	18204	48	RFX4,FGFR2,GLI3,ATP1A2,SLC1A2
4.290e-03	-5.45	MMP3 (matrix metallopeptidase 3)	protein interactions	4314	38	2	19454	50	APOE,CLU
4.290e-03	-5.45	Pcbp1 (poly(rC) binding protein 1)	protein interactions	23983	38	2	19454	50	QKI,MSI2
4.462e-03	-5.41	limbic system development	biological process	GO:0021761	126	3	18204	48	GLI3,FGFR2,ATP1A2
4.471e-03	-5.41	cellular component organization	biological process	GO:0016043	5636	24	18204	48	PTPRZ1,CLU,NFIA,RFX4,SLC1A2,GRAMD1C,ARHGEF26,TRPM3,PDLIM5,PITPNC1,APOE,ATP10B,GULP1,APC,GLI3,DAAM2,PLEKHA7,FGFR2,SPAG16,TNIK,CDC14A,ABLIM1,CTNND2,PREX2
4.480e-03	-5.41	signaling	biological process	GO:0023052	4968	22	18204	48	TNIK,PITPNC1,APOE,PLCB4,GNA14,ZNRF3,GLI3,APC,CTNND2,DAAM2,PREX2,MERTK,NFIA,CLU,IRAG1,MAML2,FNBP1,SLC1A3,SLC1A2,ATP1A2,ITPR2,FGFR2
4.481e-03	-5.41	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	13	16828	48	GLI3,ATP1A2,APC,FGFR2,FOLH1,PTPRZ1,DAAM2,TNIK,TRPS1,NFIA,PREX2,MERTK,PLEKHA7
4.505e-03	-5.40	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	48	SLC1A3,SLC1A2
4.515e-03	-5.40	TFF1 (trefoil factor 1)	protein interactions	7031	39	2	19454	50	APC,FGFR2
4.563e-03	-5.39	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	5	16828	48	MAML2,TNIK,PDLIM5,APC,FGFR2
4.563e-03	-5.39	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	5	16828	48	APC,FGFR2,PDLIM5,TNIK,MAML2
4.563e-03	-5.39	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	5	16828	48	PDLIM5,APC,FGFR2,MAML2,TNIK
4.563e-03	-5.39	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	5	16828	48	PDLIM5,FGFR2,APC,MAML2,TNIK
4.563e-03	-5.39	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	5	16828	48	FGFR2,APC,PDLIM5,TNIK,MAML2
4.639e-03	-5.37	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	47	16828	48	MERTK,QKI,ZNRF3,RFX4,FOLH1,GLI3,PITPNC1,TRPM3,NKAIN3,RPE65,DAAM2,GPC5,SPAG16,ATP1A2,NPAS3,ITPR2,PLEKHA7,ABLIM1,FNBP1,TRPS1,ARHGEF26,CTNND2,TTC28,ATP10B,GULP1,GRAMD1C,CDC14A,SLC1A2,PLCB4,CLU,LSAMP,SLC1A3,IGSF11,TNIK,LRIG1,FGFR2,PTPRZ1,MAML2,NFIA,APC,GNA14,PDLIM5,LUZP2,PREX2,ATP13A4,GLIS3,MSI2
4.639e-03	-5.37	cell fate commitment	biological process	GO:0045165	257	4	18204	48	GLI3,FGFR2,APC,NFIA
4.674e-03	-5.37	protein-lipid complex	cellular component	GO:0032994	39	2	19108	50	APOE,CLU
4.696e-03	-5.36	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	40	16828	48	LUZP2,ATP10B,PREX2,GULP1,GRAMD1C,CDC14A,ATP13A4,GLIS3,SLC1A2,MSI2,PLCB4,ITPR2,PLEKHA7,TRPS1,APC,GNA14,ARHGEF26,PDLIM5,CTNND2,TTC28,RPE65,TNIK,GPC5,DAAM2,LRIG1,SPAG16,FGFR2,ATP1A2,PTPRZ1,MAML2,NPAS3,MERTK,QKI,ZNRF3,CLU,FOLH1,GLI3,LSAMP,SLC1A3,TRPM3
4.718e-03	-5.36	central_nervous_system-thalamus-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-thalamus-glioma-astrocytoma_Grade_I	36	2	16828	48	QKI,FGFR2
4.718e-03	-5.36	carcinosarcoma-malignant_mesodermal_mixed_tumour	COSMIC cancer mutations	carcinosarcoma-malignant_mesodermal_mixed_tumour	36	2	16828	48	FGFR2,APC
4.741e-03	-5.35	cellular response to alkaloid	biological process	GO:0071312	39	2	18204	48	SLC1A2,SLC1A3
4.741e-03	-5.35	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	48	SLC1A3,ATP1A2
4.741e-03	-5.35	positive regulation of nitric oxide biosynthetic process	biological process	GO:0045429	39	2	18204	48	CLU,APOE
4.741e-03	-5.35	animal organ formation	biological process	GO:0048645	39	2	18204	48	GLI3,FGFR2
4.843e-03	-5.33	monoatomic ion transmembrane transport	biological process	GO:0034220	804	7	18204	48	ATP1A2,TRPM3,SLC1A2,SLC1A3,ITPR2,ATP13A4,PLCB4
4.901e-03	-5.32	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	7	16828	48	PREX2,RPE65,LUZP2,ATP13A4,PLCB4,FGFR2,APC
4.909e-03	-5.32	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	13	19108	50	ABLIM1,MERTK,CLU,SLC1A3,CDC14A,APC,APOE,SPAG16,SLC1A2,GLI3,ARHGEF26,CTNND2,ATP1A2
4.979e-03	-5.30	central_nervous_system-third_ventricle-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-third_ventricle-glioma-astrocytoma_Grade_I	37	2	16828	48	QKI,FGFR2
4.980e-03	-5.30	KIAA1328 (KIAA1328)	protein interactions	57536	41	2	19454	50	APC,CDC14A
4.980e-03	-5.30	LIN7B (lin-7 homolog B, crumbs cell polarity complex component)	protein interactions	64130	41	2	19454	50	ARHGEF26,APC
4.982e-03	-5.30	positive regulation of nitric oxide metabolic process	biological process	GO:1904407	40	2	18204	48	APOE,CLU
4.984e-03	-5.30	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	6	18094	46	ATP1A2,ITPR2,SLC1A2,SLC1A3,TRPM3,ATP13A4
5.003e-03	-5.30	cell communication	biological process	GO:0007154	5010	22	18204	48	ATP1A2,SLC1A3,SLC1A2,ITPR2,FGFR2,NFIA,CLU,MERTK,MAML2,FNBP1,IRAG1,DAAM2,PREX2,ZNRF3,GNA14,CTNND2,GLI3,APC,PLCB4,TNIK,PITPNC1,APOE
5.048e-03	-5.29	scalp	COSMIC cancer mutations	scalp	2110	13	16828	48	PLCB4,ATP13A4,PTPRZ1,ATP1A2,FGFR2,PREX2,GPC5,RPE65,LSAMP,APC,TRPS1,NFIA,MERTK
5.049e-03	-5.29	Myo1c (myosin IC)	protein interactions	17913	135	3	19454	50	ITPR2,ABLIM1,TRPS1
5.078e-03	-5.28	retinol isomerase activity	molecular function	GO:0050251	2	1	18094	46	RPE65
5.080e-03	-5.28	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	48	PREX2,GPC5,ATP10B,ITPR2,GLI3,TRPM3,SLC1A2,ATP13A4
5.080e-03	-5.28	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	8	16828	48	GLI3,TRPM3,ATP13A4,SLC1A2,PREX2,GPC5,ATP10B,ITPR2
5.095e-03	-5.28	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	4	18094	46	SLC1A3,ATP13A4,ATP1A2,SLC1A2
5.099e-03	-5.28	collagen-containing extracellular matrix	cellular component	GO:0062023	428	5	19108	50	CLU,GPC5,PTPRZ1,FGFR2,APOE
5.103e-03	-5.28	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	46	SLC1A2,SLC1A3
5.115e-03	-5.28	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	5	18094	46	SLC1A2,ITPR2,ATP1A2,TRPM3,SLC1A3
5.127e-03	-5.27	RHOB (ras homolog family member B)	protein interactions	388	832	7	19454	50	FNBP1,SLC1A3,ARHGEF26,TNIK,PLEKHA7,ABLIM1,PLCB4
5.134e-03	-5.27	Otud7b (OTU domain containing 7B)	protein interactions	229603	2	1	19454	50	APC
5.134e-03	-5.27	ORF43 (ORF43)	protein interactions	4961497	2	1	19454	50	DAAM2
5.134e-03	-5.27	IGSF11 (immunoglobulin superfamily member 11)	protein interactions	152404	2	1	19454	50	IGSF11
5.134e-03	-5.27	Zranb1 (zinc finger, RAN-binding domain containing 1)	protein interactions	360216	2	1	19454	50	APC
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	SYNGR4 (synaptogyrin 4)	protein interactions	23546	2	1	19454	50	GULP1
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.188e-03	-5.26	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	48	PLCB4,ITPR2,ATP1A2
5.227e-03	-5.25	chylomicron remnant	cellular component	GO:0034360	2	1	19108	50	APOE
5.227e-03	-5.25	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	50	APOE
5.246e-03	-5.25	mediastinum	COSMIC cancer mutations	mediastinum	38	2	16828	48	APC,FGFR2
5.246e-03	-5.25	central_nervous_system-brainstem-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_I	38	2	16828	48	QKI,FGFR2
5.267e-03	-5.25	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	48	CLU
5.267e-03	-5.25	mesenchymal cell differentiation involved in lung development	biological process	GO:0060915	2	1	18204	48	FGFR2
5.267e-03	-5.25	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development	biological process	GO:0060529	2	1	18204	48	FGFR2
5.267e-03	-5.25	larynx morphogenesis	biological process	GO:0120223	2	1	18204	48	GLI3
5.267e-03	-5.25	mammary gland bud formation	biological process	GO:0060615	2	1	18204	48	FGFR2
5.267e-03	-5.25	xanthophyll metabolic process	biological process	GO:0016122	2	1	18204	48	RPE65
5.267e-03	-5.25	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	48	APOE
5.267e-03	-5.25	zeaxanthin metabolic process	biological process	GO:1901825	2	1	18204	48	RPE65
5.267e-03	-5.25	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	biological process	GO:0035607	2	1	18204	48	FGFR2
5.267e-03	-5.25	positive regulation of mini excitatory postsynaptic potential	biological process	GO:0061885	2	1	18204	48	IGSF11
5.267e-03	-5.25	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	biological process	GO:0021776	2	1	18204	48	GLI3
5.267e-03	-5.25	branch elongation involved in salivary gland morphogenesis	biological process	GO:0060667	2	1	18204	48	FGFR2
5.267e-03	-5.25	myofibroblast contraction	biological process	GO:1990764	2	1	18204	48	QKI
5.267e-03	-5.25	negative regulation of 3'-UTR-mediated mRNA stabilization	biological process	GO:1905869	2	1	18204	48	QKI
5.267e-03	-5.25	Wnt receptor catabolic process	biological process	GO:0038018	2	1	18204	48	ZNRF3
5.267e-03	-5.25	larynx development	biological process	GO:0120224	2	1	18204	48	GLI3
5.343e-03	-5.23	tau protein binding	molecular function	GO:0048156	43	2	18094	46	APOE,CLU
5.378e-03	-5.23	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	15	16828	48	PLEKHA7,TRPS1,APC,CTNND2,LSAMP,SLC1A3,ATP10B,SPAG16,PREX2,GRAMD1C,ATP1A2,PTPRZ1,ATP13A4,PLCB4,MAML2
5.392e-03	-5.22	CDC14_C	interpro domains	IPR044506	2	1	18521	50	CDC14A
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.392e-03	-5.22	Apc_fam	interpro domains	IPR026818	2	1	18521	50	APC
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	MRVI1	interpro domains	IPR008677	2	1	18521	50	IRAG1
5.392e-03	-5.22	APC_rep	interpro domains	IPR041257	2	1	18521	50	APC
5.392e-03	-5.22	ZNRF-3_ecto	interpro domains	IPR040700	2	1	18521	50	ZNRF3
5.392e-03	-5.22	DSPn	interpro domains	IPR029260	2	1	18521	50	CDC14A
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	APC_dom	interpro domains	IPR026831	2	1	18521	50	APC
5.392e-03	-5.22	APC_N	interpro domains	IPR032038	2	1	18521	50	APC
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	APC_rpt	interpro domains	IPR009223	2	1	18521	50	APC
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	PLC-beta_CS	interpro domains	IPR009535	2	1	18521	50	PLCB4
5.392e-03	-5.22	SAMP	interpro domains	IPR009224	2	1	18521	50	APC
5.392e-03	-5.22	ARHGEF16/ARHGEF26_SH3	interpro domains	IPR035797	2	1	18521	50	ARHGEF26
5.392e-03	-5.22	APC_N_sf	interpro domains	IPR036149	2	1	18521	50	APC
5.392e-03	-5.22	APC_basic_dom	interpro domains	IPR009234	2	1	18521	50	APC
5.432e-03	-5.22	Ig_I-set	interpro domains	IPR013098	132	3	18521	50	LRIG1,LSAMP,FGFR2
5.500e-03	-5.20	DUF1154	pfam domains	PF06631	2	1	17795	49	PLCB4
5.500e-03	-5.20	APC_basic	pfam domains	PF05956	2	1	17795	49	APC
5.500e-03	-5.20	Arm_APC_u3	pfam domains	PF16629	2	1	17795	49	APC
5.500e-03	-5.20	ZNRF_3_ecto	pfam domains	PF18212	2	1	17795	49	ZNRF3
5.500e-03	-5.20	APC_rep	pfam domains	PF18797	2	1	17795	49	APC
5.500e-03	-5.20	SAMP	pfam domains	PF05924	2	1	17795	49	APC
5.500e-03	-5.20	APC_r	pfam domains	PF05923	2	1	17795	49	APC
5.500e-03	-5.20	MRVI1	pfam domains	PF05781	2	1	17795	49	IRAG1
5.500e-03	-5.20	APC_N_CC	pfam domains	PF16689	2	1	17795	49	APC
5.500e-03	-5.20	Clusterin	pfam domains	PF01093	2	1	17795	49	CLU
5.500e-03	-5.20	DSPn	pfam domains	PF14671	2	1	17795	49	CDC14A
5.538e-03	-5.20	human chr1p31.3	chromosome location	human chr1p31.3	58	2	26134	50	RPE65,NFIA
5.544e-03	-5.20	small_intestine	COSMIC cancer mutations	small_intestine	250	4	16828	48	FGFR2,APC,TNIK,ZNRF3
5.585e-03	-5.19	KIF7 (kinesin family member 7)	protein interactions	374654	140	3	19454	50	TNIK,GLI3,APC
5.611e-03	-5.18	TJP2 (tight junction protein 2)	protein interactions	9414	278	4	19454	50	PDLIM5,TTC28,FNBP1,APC
5.700e-03	-5.17	lipid binding	molecular function	GO:0008289	861	7	18094	46	ATP1A2,PITPNC1,APOE,FNBP1,ITPR2,GRAMD1C,RPE65
5.704e-03	-5.17	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	43	16828	48	FOLH1,CLU,TRPM3,SLC1A3,PITPNC1,GLI3,LSAMP,MERTK,QKI,RFX4,ATP1A2,FGFR2,PTPRZ1,NPAS3,MAML2,IGSF11,RPE65,NKAIN3,DAAM2,GPC5,TNIK,SPAG16,LRIG1,APC,GNA14,PDLIM5,ARHGEF26,TTC28,CTNND2,ITPR2,ABLIM1,PLEKHA7,TRPS1,NFIA,GRAMD1C,GULP1,SLC1A2,GLIS3,ATP13A4,PLCB4,LUZP2,ATP10B,PREX2
5.731e-03	-5.16	I-set	pfam domains	PF07679	132	3	17795	49	LRIG1,FGFR2,LSAMP
5.732e-03	-5.16	Vascular smooth muscle contraction	KEGG pathways	hsa04270	121	3	7161	22	PLCB4,ITPR2,IRAG1
5.732e-03	-5.16	Vascular smooth muscle contraction	KEGG pathways	ko04270	121	3	7161	22	PLCB4,ITPR2,IRAG1
5.737e-03	-5.16	vascular process in circulatory system	biological process	GO:0003018	273	4	18204	48	APOE,ATP1A2,SLC1A2,SLC1A3
5.740e-03	-5.16	Armadillo	interpro domains	IPR000225	42	2	18521	50	CTNND2,APC
5.756e-03	-5.16	anion binding	molecular function	GO:0043168	2412	13	18094	46	ETNPPL,MERTK,ATP10B,FOLH1,FGFR2,SLC1A3,PITPNC1,GNA14,ATP13A4,TNIK,RPE65,ITPR2,ATP1A2
5.959e-03	-5.12	upper_arm	COSMIC cancer mutations	upper_arm	582	6	16828	48	SPAG16,PREX2,ITPR2,APC,FGFR2,FOLH1
5.960e-03	-5.12	telencephalon development	biological process	GO:0021537	276	4	18204	48	GLI3,RFX4,SLC1A2,ATP1A2
5.978e-03	-5.12	PH-like_dom_sf	interpro domains	IPR011993	431	5	18521	50	PLEKHA7,GRAMD1C,PREX2,GULP1,ARHGEF26
5.980e-03	-5.12	neurotransmitter transport	biological process	GO:0006836	140	3	18204	48	SLC1A2,SLC1A3,ATP1A2
6.002e-03	-5.12	mammary gland morphogenesis	biological process	GO:0060443	44	2	18204	48	FGFR2,GLI3
6.035e-03	-5.11	Ig-like_dom	interpro domains	IPR007110	432	5	18521	50	LSAMP,FGFR2,MERTK,LRIG1,IGSF11
6.261e-03	-5.07	monoatomic cation transmembrane transport	biological process	GO:0098655	636	6	18204	48	ATP1A2,TRPM3,SLC1A3,PLCB4,ITPR2,ATP13A4
6.270e-03	-5.07	acidic amino acid transport	biological process	GO:0015800	45	2	18204	48	SLC1A2,SLC1A3
6.270e-03	-5.07	embryonic cranial skeleton morphogenesis	biological process	GO:0048701	45	2	18204	48	GLI3,FGFR2
6.379e-03	-5.05	cervix-carcinoma	COSMIC cancer mutations	cervix-carcinoma	42	2	16828	48	FGFR2,APC
6.467e-03	-5.04	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	39	16828	48	MAML2,NPAS3,ATP1A2,FGFR2,PTPRZ1,DAAM2,GPC5,TNIK,SPAG16,LRIG1,RPE65,TRPM3,SLC1A3,LSAMP,GLI3,FOLH1,CLU,QKI,ZNRF3,MERTK,SLC1A2,ATP13A4,GLIS3,PLCB4,MSI2,GRAMD1C,GULP1,CDC14A,ATP10B,PREX2,LUZP2,CTNND2,GNA14,APC,PDLIM5,ARHGEF26,TRPS1,ITPR2,PLEKHA7
6.544e-03	-5.03	positive regulation of glial cell differentiation	biological process	GO:0045687	46	2	18204	48	PTPRZ1,QKI
6.568e-03	-5.03	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	6	16828	48	CTNND2,SPAG16,TRPS1,PREX2,APC,PLEKHA7
6.590e-03	-5.02	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	20	16828	48	LSAMP,TRPM3,CTNND2,FOLH1,APC,ZNRF3,TRPS1,NFIA,ITPR2,PLCB4,ATP13A4,GLIS3,PTPRZ1,GULP1,FGFR2,ATP1A2,LRIG1,TNIK,GPC5,ATP10B
6.599e-03	-5.02	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	9	19454	50	QKI,CLU,LSAMP,MSI2,GLIS3,TRPS1,GLI3,NFIA,ITPR2
6.715e-03	-5.00	adult behavior	biological process	GO:0030534	146	3	18204	48	PREX2,SLC1A2,ATP1A2
6.715e-03	-5.00	positive regulation of Wnt signaling pathway	biological process	GO:0030177	146	3	18204	48	DAAM2,GPC5,FGFR2
6.782e-03	-4.99	localization	biological process	GO:0051179	4474	20	18204	48	ATP13A4,GLI3,GULP1,PLCB4,TNIK,PITPNC1,APOE,ATP10B,SPAG16,ITPR2,ATP1A2,TRPM3,SLC1A3,GRAMD1C,SLC1A2,IGSF11,FNBP1,QKI,CLU,MERTK
6.824e-03	-4.99	regulation of long-term synaptic potentiation	biological process	GO:1900271	47	2	18204	48	IGSF11,APOE
7.109e-03	-4.95	regulation of amyloid-beta formation	biological process	GO:1902003	48	2	18204	48	CLU,APOE
7.109e-03	-4.95	digestive tract morphogenesis	biological process	GO:0048546	48	2	18204	48	GLI3,FGFR2
7.110e-03	-4.95	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	13	16828	48	APC,FOLH1,GLI3,PLEKHA7,MERTK,NFIA,TRPS1,FGFR2,ATP1A2,PTPRZ1,TNIK,DAAM2,PREX2
7.157e-03	-4.94	sole	COSMIC cancer mutations	sole	269	4	16828	48	FGFR2,APC,LUZP2,PLCB4
7.215e-03	-4.93	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	12	16828	48	NPAS3,PLCB4,MAML2,IGSF11,TNIK,DAAM2,SPAG16,APC,PDLIM5,GLI3,ITPR2,ZNRF3
7.233e-03	-4.93	appendage morphogenesis	biological process	GO:0035107	150	3	18204	48	NFIA,FGFR2,GLI3
7.233e-03	-4.93	limb morphogenesis	biological process	GO:0035108	150	3	18204	48	GLI3,FGFR2,NFIA
7.272e-03	-4.92	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	3	16828	48	QKI,GPC5,FGFR2
7.274e-03	-4.92	larynx	COSMIC cancer mutations	larynx	1948	12	16828	48	ITPR2,ZNRF3,APC,PDLIM5,GLI3,IGSF11,TNIK,DAAM2,SPAG16,NPAS3,PLCB4,MAML2
7.295e-03	-4.92	alveolar_soft_part_sarcoma	COSMIC cancer mutations	alveolar_soft_part_sarcoma	45	2	16828	48	APC,FGFR2
7.295e-03	-4.92	anaplastic_large_cell_lymphoma	COSMIC cancer mutations	anaplastic_large_cell_lymphoma	45	2	16828	48	FGFR2,APC
7.295e-03	-4.92	soft_tissue-fibrous_tissue_and_uncertain_origin-alveolar_soft_part_sarcoma	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-alveolar_soft_part_sarcoma	45	2	16828	48	FGFR2,APC
7.295e-03	-4.92	third_ventricle	COSMIC cancer mutations	third_ventricle	45	2	16828	48	QKI,FGFR2
7.396e-03	-4.91	CLa	smart domains	SM00035	2	1	9717	36	CLU
7.396e-03	-4.91	CLb	smart domains	SM00030	2	1	9717	36	CLU
7.521e-03	-4.89	cellular component organization or biogenesis	biological process	GO:0071840	5850	24	18204	48	RFX4,NFIA,CLU,PTPRZ1,TRPM3,ARHGEF26,SLC1A2,GRAMD1C,GULP1,ATP10B,APOE,PITPNC1,PDLIM5,DAAM2,APC,GLI3,PLEKHA7,FGFR2,TNIK,SPAG16,PREX2,CTNND2,ABLIM1,CDC14A
7.534e-03	-4.89	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	3	18094	46	SLC1A3,ATP1A2,SLC1A2
7.566e-03	-4.88	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	38	16828	48	RPE65,NKAIN3,IGSF11,SPAG16,LRIG1,GPC5,TNIK,PTPRZ1,ATP1A2,FGFR2,NPAS3,MERTK,RFX4,ZNRF3,FOLH1,TRPM3,PITPNC1,SLC1A3,LSAMP,GLI3,LUZP2,PREX2,ATP10B,CDC14A,GRAMD1C,PLCB4,ATP13A4,SLC1A2,GLIS3,ABLIM1,PLEKHA7,ITPR2,NFIA,TRPS1,PDLIM5,APC,APOE,CTNND2
7.566e-03	-4.88	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	38	16828	48	CDC14A,GRAMD1C,PLCB4,ATP13A4,SLC1A2,GLIS3,LUZP2,PREX2,ATP10B,PDLIM5,APC,APOE,CTNND2,ABLIM1,PLEKHA7,ITPR2,NFIA,TRPS1,PTPRZ1,ATP1A2,FGFR2,NPAS3,RPE65,NKAIN3,IGSF11,SPAG16,LRIG1,GPC5,TNIK,FOLH1,SLC1A3,TRPM3,PITPNC1,LSAMP,GLI3,MERTK,RFX4,ZNRF3
7.608e-03	-4.88	beta-carotene 15,15'-dioxygenase activity	molecular function	GO:0003834	3	1	18094	46	RPE65
7.608e-03	-4.88	glycosylceramide flippase activity	molecular function	GO:0140351	3	1	18094	46	ATP10B
7.608e-03	-4.88	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	46	SLC1A2
7.608e-03	-4.88	inositol 1,4,5-trisphosphate-gated calcium channel activity	molecular function	GO:0005220	3	1	18094	46	ITPR2
7.612e-03	-4.88	endometrium-carcinoma	COSMIC cancer mutations	endometrium-carcinoma	46	2	16828	48	APC,FGFR2
7.612e-03	-4.88	vulva	COSMIC cancer mutations	vulva	46	2	16828	48	FGFR2,APC
7.612e-03	-4.88	peritoneum-mesothelioma	COSMIC cancer mutations	peritoneum-mesothelioma	46	2	16828	48	APC,FGFR2
7.617e-03	-4.88	BEX1 (brain expressed X-linked 1)	protein interactions	55859	51	2	19454	50	FGFR2,TNIK
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.636e-03	-4.87	organophosphate ester transport	biological process	GO:0015748	153	3	18204	48	APOE,ATP10B,PITPNC1
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Shh (sonic hedgehog)	protein interactions	20423	3	1	19454	50	GLI3
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	IGFL2 (IGF like family member 2)	protein interactions	147920	3	1	19454	50	PLEKHA7
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.720e-03	-4.86	establishment of localization	biological process	GO:0051234	3887	18	18204	48	GRAMD1C,SLC1A3,SLC1A2,ATP1A2,TRPM3,ITPR2,MERTK,CLU,QKI,FNBP1,ATP13A4,GLI3,SPAG16,PITPNC1,ATP10B,APOE,GULP1,PLCB4
7.830e-03	-4.85	kinociliary basal body	cellular component	GO:1902636	3	1	19108	50	CDC14A
7.871e-03	-4.84	pleura-mesothelioma	COSMIC cancer mutations	pleura-mesothelioma	4189	20	16828	48	TNIK,DAAM2,PREX2,LRIG1,MSI2,MAML2,PLCB4,FGFR2,CDC14A,PTPRZ1,QKI,TRPS1,ITPR2,PLEKHA7,MERTK,CTNND2,GLI3,PITPNC1,GNA14,CLU
7.890e-03	-4.84	cysteine transport	biological process	GO:0042883	3	1	18204	48	SLC1A2
7.890e-03	-4.84	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	48	CLU
7.890e-03	-4.84	tetraterpenoid metabolic process	biological process	GO:0016108	3	1	18204	48	RPE65
7.890e-03	-4.84	ventricular zone neuroblast division	biological process	GO:0021847	3	1	18204	48	FGFR2
7.890e-03	-4.84	carotenoid metabolic process	biological process	GO:0016116	3	1	18204	48	RPE65
7.890e-03	-4.84	mammary gland bud morphogenesis	biological process	GO:0060648	3	1	18204	48	FGFR2
7.890e-03	-4.84	orbitofrontal cortex development	biological process	GO:0021769	3	1	18204	48	FGFR2
7.890e-03	-4.84	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	48	SLC1A2
7.890e-03	-4.84	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	48	APOE
7.890e-03	-4.84	smoothened signaling pathway involved in ventral spinal cord patterning	biological process	GO:0021910	3	1	18204	48	GLI3
7.890e-03	-4.84	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	48	APOE
7.890e-03	-4.84	prostate epithelial cord elongation	biological process	GO:0060523	3	1	18204	48	FGFR2
7.890e-03	-4.84	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	48	ATP1A2
7.890e-03	-4.84	zonula adherens maintenance	biological process	GO:0045218	3	1	18204	48	PLEKHA7
7.890e-03	-4.84	smoothened signaling pathway involved in ventral spinal cord interneuron specification	biological process	GO:0021775	3	1	18204	48	GLI3
7.890e-03	-4.84	immune complex clearance	biological process	GO:0002434	3	1	18204	48	CLU
7.890e-03	-4.84	nose morphogenesis	biological process	GO:0043585	3	1	18204	48	GLI3
7.928e-03	-4.84	TYRO3 (TYRO3 protein tyrosine kinase)	protein interactions	7301	159	3	19454	50	CLU,APOE,SLC1A3
7.936e-03	-4.84	haematopoietic_and_lymphoid_tissue-pharynx-haematopoietic_neoplasm-blastic_plasmacytoid_dendritic_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-pharynx-haematopoietic_neoplasm-blastic_plasmacytoid_dendritic_cell_neoplasm	47	2	16828	48	FGFR2,APC
8.015e-03	-4.83	INSP3RECEPTR	prints domains	PR00779	3	1	5227	14	ITPR2
8.024e-03	-4.83	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	46	ATP1A2,ATP13A4
8.030e-03	-4.82	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	30	16828	48	APC,GNA14,PDLIM5,CTNND2,ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1,GLIS3,ATP13A4,ATP10B,PREX2,SLC1A3,TRPM3,GLI3,MERTK,QKI,ATP1A2,FGFR2,PTPRZ1,NPAS3,MAML2,IGSF11,RPE65,NKAIN3,DAAM2,TNIK,LRIG1,SPAG16
8.053e-03	-4.82	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	48	NFIA,MERTK,RPE65
8.078e-03	-4.82	MAML1-3	interpro domains	IPR046369	3	1	18521	50	MAML2
8.078e-03	-4.82	VASt	interpro domains	IPR031968	3	1	18521	50	GRAMD1C
8.078e-03	-4.82	MAML_N_sf	interpro domains	IPR046370	3	1	18521	50	MAML2
8.078e-03	-4.82	Carotenoid_Oase	interpro domains	IPR004294	3	1	18521	50	RPE65
8.078e-03	-4.82	InsP3_rcpt	interpro domains	IPR000493	3	1	18521	50	ITPR2
8.078e-03	-4.82	Mastermind-like_N	interpro domains	IPR019082	3	1	18521	50	MAML2
8.178e-03	-4.81	Retinoid metabolism and transport	REACTOME pathways	R-HSA-975634	44	2	10285	32	GPC5,APOE
8.195e-03	-4.80	positive regulation of endocytosis	biological process	GO:0045807	157	3	18204	48	APOE,CLU,MERTK
8.200e-03	-4.80	pancreas-carcinoma-acinar_carcinoma	COSMIC cancer mutations	pancreas-carcinoma-acinar_carcinoma	1978	12	16828	48	ATP1A2,FGFR2,PTPRZ1,PLCB4,ATP10B,GNA14,APC,PDLIM5,CTNND2,TRPM3,GLI3,QKI
8.200e-03	-4.80	acinar_carcinoma	COSMIC cancer mutations	acinar_carcinoma	1978	12	16828	48	PTPRZ1,FGFR2,ATP1A2,PLCB4,ATP10B,PDLIM5,GNA14,APC,GLI3,TRPM3,CTNND2,QKI
8.220e-03	-4.80	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	4	16828	48	PREX2,PLCB4,TNIK,ATP1A2
8.238e-03	-4.80	VASt	pfam domains	PF16016	3	1	17795	49	GRAMD1C
8.238e-03	-4.80	RPE65	pfam domains	PF03055	3	1	17795	49	RPE65
8.238e-03	-4.80	MamL-1	pfam domains	PF09596	3	1	17795	49	MAML2
8.266e-03	-4.80	dysplasia-in_situ_neoplasm	COSMIC cancer mutations	dysplasia-in_situ_neoplasm	48	2	16828	48	FGFR2,APC
8.266e-03	-4.80	pancreas-other-dysplasia-in_situ_neoplasm	COSMIC cancer mutations	pancreas-other-dysplasia-in_situ_neoplasm	48	2	16828	48	APC,FGFR2
8.288e-03	-4.79	ear	COSMIC cancer mutations	ear	624	6	16828	48	ATP10B,NPAS3,PLCB4,APC,FGFR2,CDC14A
8.301e-03	-4.79	forebrain generation of neurons	biological process	GO:0021872	52	2	18204	48	FGFR2,GLI3
8.343e-03	-4.79	DSCAM (DS cell adhesion molecule)	protein interactions	1826	162	3	19454	50	CLU,MERTK,PDLIM5
8.369e-03	-4.78	cell surface	cellular component	GO:0009986	896	7	19108	50	FOLH1,CLU,SLC1A3,SLC1A2,GPC5,FGFR2,ATP1A2
8.411e-03	-4.78	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	35	16828	48	ITPR2,PLEKHA7,NFIA,TRPS1,GNA14,APC,PDLIM5,TTC28,CTNND2,APOE,LUZP2,ATP10B,PREX2,CDC14A,GLIS3,PLCB4,MSI2,MERTK,QKI,FOLH1,CLU,TRPM3,PITPNC1,GLI3,LSAMP,NKAIN3,DAAM2,GPC5,TNIK,LRIG1,SPAG16,ATP1A2,FGFR2,PTPRZ1,MAML2
8.533e-03	-4.76	bone-mandible-carcinoma-ameloblastic_carcinoma	COSMIC cancer mutations	bone-mandible-carcinoma-ameloblastic_carcinoma	3	1	16828	48	APC
8.533e-03	-4.76	plantar_superficial_fibromatosis	COSMIC cancer mutations	plantar_superficial_fibromatosis	3	1	16828	48	APC
8.533e-03	-4.76	hyperplastic	COSMIC cancer mutations	hyperplastic	3	1	16828	48	APC
8.533e-03	-4.76	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	3	1	16828	48	APC
8.533e-03	-4.76	bone-cemento-ossifying_fibroma	COSMIC cancer mutations	bone-cemento-ossifying_fibroma	3	1	16828	48	APC
8.533e-03	-4.76	cemento-osseous_dysplasia	COSMIC cancer mutations	cemento-osseous_dysplasia	3	1	16828	48	APC
8.533e-03	-4.76	steroid_cell_tumour	COSMIC cancer mutations	steroid_cell_tumour	3	1	16828	48	APC
8.533e-03	-4.76	labia_major	COSMIC cancer mutations	labia_major	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-colon-serrated_polyp-admixed_hyperplastic_polyp-adenoma	COSMIC cancer mutations	large_intestine-colon-serrated_polyp-admixed_hyperplastic_polyp-adenoma	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-colon-other-juvenile_polyp	COSMIC cancer mutations	large_intestine-colon-other-juvenile_polyp	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-colon-other-Crohn_disease	COSMIC cancer mutations	large_intestine-colon-other-Crohn_disease	3	1	16828	48	APC
8.533e-03	-4.76	ameloblastic_carcinoma	COSMIC cancer mutations	ameloblastic_carcinoma	3	1	16828	48	APC
8.533e-03	-4.76	soft_tissue-fibrous_tissue_and_uncertain_origin-palmar_superficial_fibromatosis	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-palmar_superficial_fibromatosis	3	1	16828	48	APC
8.533e-03	-4.76	desmoplastic_fibroma	COSMIC cancer mutations	desmoplastic_fibroma	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-aberrant_crypt_foci-hyperplastic	COSMIC cancer mutations	large_intestine-aberrant_crypt_foci-hyperplastic	3	1	16828	48	APC
8.533e-03	-4.76	Crohn_disease	COSMIC cancer mutations	Crohn_disease	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-colon-adenoma-mixed_serrated_and_tubulovillous	COSMIC cancer mutations	large_intestine-colon-adenoma-mixed_serrated_and_tubulovillous	3	1	16828	48	APC
8.533e-03	-4.76	bone-fibrous_dysplasia	COSMIC cancer mutations	bone-fibrous_dysplasia	3	1	16828	48	APC
8.533e-03	-4.76	benign_stromal_nodule	COSMIC cancer mutations	benign_stromal_nodule	3	1	16828	48	APC
8.533e-03	-4.76	mixed_serrated_and_tubulovillous	COSMIC cancer mutations	mixed_serrated_and_tubulovillous	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-rectum-adenoma-mixed_serrated_and_tubulovillous	COSMIC cancer mutations	large_intestine-rectum-adenoma-mixed_serrated_and_tubulovillous	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-aberrant_crypt_foci	COSMIC cancer mutations	large_intestine-aberrant_crypt_foci	3	1	16828	48	APC
8.533e-03	-4.76	soft_tissue-fibrous_tissue_and_uncertain_origin-plantar_superficial_fibromatosis	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-plantar_superficial_fibromatosis	3	1	16828	48	APC
8.533e-03	-4.76	central_nervous_system-glioma-ependymoma_Grade_III-IV	COSMIC cancer mutations	central_nervous_system-glioma-ependymoma_Grade_III-IV	3	1	16828	48	APC
8.533e-03	-4.76	endometrium-other-benign_stromal_nodule	COSMIC cancer mutations	endometrium-other-benign_stromal_nodule	3	1	16828	48	APC
8.533e-03	-4.76	large_intestine-colon-aberrant_crypt_foci	COSMIC cancer mutations	large_intestine-colon-aberrant_crypt_foci	3	1	16828	48	APC
8.533e-03	-4.76	gastrointestinal_tract_(site_indeterminate)-other-juvenile_polyp	COSMIC cancer mutations	gastrointestinal_tract_(site_indeterminate)-other-juvenile_polyp	3	1	16828	48	APC
8.533e-03	-4.76	ovary-sex_cord-stromal_tumour-steroid_cell_tumour	COSMIC cancer mutations	ovary-sex_cord-stromal_tumour-steroid_cell_tumour	3	1	16828	48	APC
8.533e-03	-4.76	bone-mandible-cemento-osseous_dysplasia	COSMIC cancer mutations	bone-mandible-cemento-osseous_dysplasia	3	1	16828	48	APC
8.533e-03	-4.76	palmar_superficial_fibromatosis	COSMIC cancer mutations	palmar_superficial_fibromatosis	3	1	16828	48	APC
8.533e-03	-4.76	fibro-osseous_lesion_NOS	COSMIC cancer mutations	fibro-osseous_lesion_NOS	3	1	16828	48	APC
8.575e-03	-4.76	organic substance transport	biological process	GO:0071702	1881	11	18204	48	SLC1A2,GRAMD1C,SLC1A3,CLU,QKI,ATP13A4,GLI3,GULP1,APOE,ATP10B,PITPNC1
8.612e-03	-4.75	neutral amino acid transport	biological process	GO:0015804	53	2	18204	48	SLC1A3,SLC1A2
8.612e-03	-4.75	regulation of chondrocyte differentiation	biological process	GO:0032330	53	2	18204	48	TRPS1,GLI3
8.635e-03	-4.75	foot	COSMIC cancer mutations	foot	148	3	16828	48	PREX2,PLCB4,APC
8.690e-03	-4.75	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	gene3d domains	2.30.29.30	431	5	14470	43	GULP1,PREX2,GRAMD1C,PLEKHA7,ARHGEF26
8.777e-03	-4.74	sensory perception of sound	biological process	GO:0007605	161	3	18204	48	SLC1A3,LRIG1,CDC14A
8.777e-03	-4.74	negative regulation of supramolecular fiber organization	biological process	GO:1902904	161	3	18204	48	CLU,APC,APOE
8.794e-03	-4.73	eye-uveal_tract-malignant_melanoma	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma	149	3	16828	48	APC,FGFR2,TTC28
8.854e-03	-4.73	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	21	16828	48	LRIG1,PREX2,DAAM2,TNIK,MAML2,PLCB4,MSI2,PTPRZ1,CDC14A,FGFR2,TRPS1,ZNRF3,QKI,MERTK,PLEKHA7,ITPR2,PITPNC1,GLI3,CTNND2,CLU,GNA14
8.854e-03	-4.73	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	21	16828	48	DAAM2,TNIK,PREX2,LRIG1,PLCB4,MAML2,MSI2,FGFR2,PTPRZ1,CDC14A,QKI,TRPS1,ZNRF3,ITPR2,MERTK,PLEKHA7,CTNND2,PITPNC1,GLI3,GNA14,CLU
8.889e-03	-4.72	Helix hairpin bin	gene3d domains	1.10.287.450	3	1	14470	43	APC
8.889e-03	-4.72	-	gene3d domains	6.10.250.970	3	1	14470	43	MAML2
8.945e-03	-4.72	thyroid-chronic_thyroiditis	COSMIC cancer mutations	thyroid-chronic_thyroiditis	50	2	16828	48	APC,FGFR2
8.945e-03	-4.72	chronic_thyroiditis	COSMIC cancer mutations	chronic_thyroiditis	50	2	16828	48	FGFR2,APC
8.945e-03	-4.72	adrenal_gland-pheochromocytoma	COSMIC cancer mutations	adrenal_gland-pheochromocytoma	50	2	16828	48	APC,FGFR2
8.959e-03	-4.72	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	hsa04961	47	2	7161	22	PLCB4,ATP1A2
8.959e-03	-4.72	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	ko04961	47	2	7161	22	ATP1A2,PLCB4
8.970e-03	-4.71	nervous system process	biological process	GO:0050877	1376	9	18204	48	PTPRZ1,SPAG16,APOE,SLC1A3,LRIG1,ATP1A2,ABLIM1,CDC14A,RPE65
9.054e-03	-4.70	cellular response to endogenous stimulus	biological process	GO:0071495	1135	8	18204	48	APC,FGFR2,ITPR2,GNA14,SLC1A2,SLC1A3,ATP1A2,NFIA
9.074e-03	-4.70	ARM	smart domains	SM00185	39	2	9717	36	CTNND2,APC
9.093e-03	-4.70	Wnt signaling pathway	KEGG pathways	ko04310	143	3	7161	22	DAAM2,APC,PLCB4
9.093e-03	-4.70	Wnt signaling pathway	KEGG pathways	hsa04310	143	3	7161	22	PLCB4,DAAM2,APC
9.109e-03	-4.70	response to light stimulus	biological process	GO:0009416	312	4	18204	48	RPE65,ATP1A2,SLC1A3,SLC1A2
9.125e-03	-4.70	Flot2 (flotillin 2)	protein interactions	14252	56	2	19454	50	ABLIM1,APC
9.125e-03	-4.70	CSTL1 (cystatin like 1)	protein interactions	128817	56	2	19454	50	CLU,APOE
9.212e-03	-4.69	PPL (periplakin)	protein interactions	5493	168	3	19454	50	PLEKHA7,ITPR2,NKAIN3
9.249e-03	-4.68	regulation of amyloid precursor protein catabolic process	biological process	GO:1902991	55	2	18204	48	CLU,APOE
9.249e-03	-4.68	response to cocaine	biological process	GO:0042220	55	2	18204	48	SLC1A3,SLC1A2
9.253e-03	-4.68	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	12	16828	48	PLEKHA7,ABLIM1,CTNND2,PDLIM5,APC,PREX2,LUZP2,PLCB4,ATP13A4,FGFR2,GRAMD1C,ATP1A2
9.253e-03	-4.68	mucosal	COSMIC cancer mutations	mucosal	2009	12	16828	48	ABLIM1,PLEKHA7,CTNND2,PDLIM5,APC,PREX2,LUZP2,PLCB4,ATP13A4,GRAMD1C,ATP1A2,FGFR2
9.291e-03	-4.68	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	2	10285	32	ITPR2,PLCB4
9.293e-03	-4.68	haematopoietic_and_lymphoid_tissue-tonsil-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-tonsil-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	51	2	16828	48	APC,ITPR2
9.293e-03	-4.68	endometrium-carcinoma-adenocarcinoma	COSMIC cancer mutations	endometrium-carcinoma-adenocarcinoma	51	2	16828	48	APC,FGFR2
9.306e-03	-4.68	GLI proteins bind promoters of Hh responsive genes to promote transcription	REACTOME pathways	R-HSA-5635851	3	1	10285	32	GLI3
9.315e-03	-4.68	nodular	COSMIC cancer mutations	nodular	1515	10	16828	48	APC,FGFR2,ATP1A2,PTPRZ1,CTNND2,GLIS3,ATP13A4,NPAS3,ABLIM1,PREX2
9.342e-03	-4.67	cell differentiation	biological process	GO:0030154	3645	17	18204	48	QKI,CLU,NFIA,MERTK,PTPRZ1,FGFR2,ARHGEF26,SLC1A3,APOE,TNIK,MSI2,SPAG16,PDLIM5,PREX2,APC,CTNND2,GLI3
9.383e-03	-4.67	import across plasma membrane	biological process	GO:0098739	165	3	18204	48	ATP1A2,SLC1A3,SLC1A2
9.391e-03	-4.67	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	46	16828	48	ABLIM1,PLEKHA7,ITPR2,TRPS1,FNBP1,ARHGEF26,TTC28,CTNND2,ATP10B,CDC14A,GRAMD1C,GULP1,PLCB4,SLC1A2,MERTK,RFX4,ZNRF3,QKI,FOLH1,PITPNC1,TRPM3,GLI3,RPE65,SPAG16,GPC5,DAAM2,ATP1A2,NPAS3,NFIA,PDLIM5,GNA14,APC,LUZP2,PREX2,MSI2,ATP13A4,GLIS3,CLU,SLC1A3,LSAMP,IGSF11,LRIG1,TNIK,PTPRZ1,FGFR2,MAML2
9.401e-03	-4.67	postsynaptic density	cellular component	GO:0014069	317	4	19108	50	TNIK,CTNND2,IGSF11,PDLIM5
9.419e-03	-4.66	cellular developmental process	biological process	GO:0048869	3648	17	18204	48	CTNND2,APC,GLI3,PREX2,SPAG16,PDLIM5,APOE,TNIK,MSI2,ARHGEF26,SLC1A3,FGFR2,MERTK,PTPRZ1,NFIA,CLU,QKI
9.538e-03	-4.65	organic hydroxy compound transport	biological process	GO:0015850	166	3	18204	48	GRAMD1C,CLU,APOE
9.541e-03	-4.65	Ig-like_dom_sf	interpro domains	IPR036179	483	5	18521	50	FGFR2,LSAMP,LRIG1,IGSF11,MERTK
9.576e-03	-4.65	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	48	ITPR2,PLCB4
9.630e-03	-4.64	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	4	19454	50	APC,PLEKHA7,ABLIM1,TNIK
9.647e-03	-4.64	undifferentiated_adenocarcinoma	COSMIC cancer mutations	undifferentiated_adenocarcinoma	52	2	16828	48	FGFR2,APC
9.647e-03	-4.64	teratoma	COSMIC cancer mutations	teratoma	52	2	16828	48	APC,FGFR2
9.647e-03	-4.64	hyperplasia	COSMIC cancer mutations	hyperplasia	52	2	16828	48	APC,FGFR2
9.647e-03	-4.64	stomach-carcinoma-undifferentiated_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-undifferentiated_adenocarcinoma	52	2	16828	48	APC,FGFR2
9.676e-03	-4.64	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	2	10285	32	ITPR2,PLCB4
9.763e-03	-4.63	ZMAT5 (zinc finger matrin-type 5)	protein interactions	55954	58	2	19454	50	PLEKHA7,QKI
9.834e-03	-4.62	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	9	16828	48	ABLIM1,PREX2,PTPRZ1,FGFR2,ATP1A2,NPAS3,CTNND2,GLIS3,ATP13A4
9.908e-03	-4.61	visual behavior	biological process	GO:0007632	57	2	18204	48	ATP1A2,SLC1A2
9.908e-03	-4.61	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	48	ITPR2,PLCB4
9.908e-03	-4.61	neuroblast proliferation	biological process	GO:0007405	57	2	18204	48	GLI3,FGFR2
9.953e-03	-4.61	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	6	16828	48	TRPM3,TNIK,QKI,PREX2,IGSF11,ABLIM1
1.001e-02	-4.60	mycosis_fungoides-Sezary_syndrome	COSMIC cancer mutations	mycosis_fungoides-Sezary_syndrome	53	2	16828	48	FGFR2,APC
1.001e-02	-4.60	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-mycosis_fungoides-Sezary_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-skin-lymphoid_neoplasm-mycosis_fungoides-Sezary_syndrome	53	2	16828	48	FGFR2,APC
1.006e-02	-4.60	VAST	prosite domains	PS51778	3	1	12186	41	GRAMD1C
1.009e-02	-4.60	VEGFA (vascular endothelial growth factor A)	protein interactions	7422	59	2	19454	50	PTPRZ1,CLU
1.009e-02	-4.60	HBA1 (hemoglobin subunit alpha 1)	protein interactions	3039	59	2	19454	50	CLU,MERTK
1.013e-02	-4.59	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	46	APOE
1.013e-02	-4.59	mediator complex binding	molecular function	GO:0036033	4	1	18094	46	GLI3
1.013e-02	-4.59	carbon-oxygen lyase activity, acting on phosphates	molecular function	GO:0016838	4	1	18094	46	ETNPPL
1.017e-02	-4.59	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	298	4	16828	48	LRIG1,CTNND2,FOLH1,ATP1A2
1.024e-02	-4.58	MEIG1 (meiosis/spermiogenesis associated 1)	protein interactions	644890	4	1	19454	50	SPAG16
1.024e-02	-4.58	Sufu (SUFU negative regulator of hedgehog signaling)	protein interactions	24069	4	1	19454	50	GLI3
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.027e-02	-4.58	signal transduction	biological process	GO:0007165	4637	20	18204	48	MAML2,FNBP1,IRAG1,CLU,NFIA,MERTK,ITPR2,FGFR2,ATP1A2,PLCB4,TNIK,PITPNC1,APOE,DAAM2,PREX2,GNA14,ZNRF3,CTNND2,APC,GLI3
1.029e-02	-4.58	LRP1 (LDL receptor related protein 1)	protein interactions	4035	175	3	19454	50	APOE,CLU,GULP1
1.034e-02	-4.57	cellular response to organonitrogen compound	biological process	GO:0071417	505	5	18204	48	APC,GNA14,ITPR2,SLC1A2,SLC1A3
1.034e-02	-4.57	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	7	19454	50	TTC28,SLC1A3,FNBP1,TRPS1,ATP13A4,CTNND2,NFIA
1.037e-02	-4.57	myeloproliferative_neoplasm	COSMIC cancer mutations	myeloproliferative_neoplasm	54	2	16828	48	APC,DAAM2
1.037e-02	-4.57	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myeloproliferative_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myeloproliferative_neoplasm	54	2	16828	48	APC,DAAM2
1.042e-02	-4.56	ITGA8 (integrin subunit alpha 8)	protein interactions	8516	60	2	19454	50	ZNRF3,CLU
1.043e-02	-4.56	axonemal central apparatus	cellular component	GO:1990716	4	1	19108	50	SPAG16
1.043e-02	-4.56	GLI-SUFU complex	cellular component	GO:1990788	4	1	19108	50	GLI3
1.043e-02	-4.56	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	50	APOE
1.051e-02	-4.56	response to caloric restriction	biological process	GO:0061771	4	1	18204	48	APOE
1.051e-02	-4.56	response to glycoside	biological process	GO:1903416	4	1	18204	48	ATP1A2
1.051e-02	-4.56	regulation of mini excitatory postsynaptic potential	biological process	GO:0061884	4	1	18204	48	IGSF11
1.051e-02	-4.56	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	48	APOE
1.051e-02	-4.56	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	48	ATP1A2
1.051e-02	-4.56	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	biological process	GO:0060831	4	1	18204	48	GLI3
1.051e-02	-4.56	prostate gland morphogenetic growth	biological process	GO:0060737	4	1	18204	48	FGFR2
1.051e-02	-4.56	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	48	CLU
1.051e-02	-4.56	negative regulation of apoptotic process in bone marrow cell	biological process	GO:0071866	4	1	18204	48	FGFR2
1.051e-02	-4.56	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	48	APOE
1.051e-02	-4.56	frontal suture morphogenesis	biological process	GO:0060364	4	1	18204	48	GLI3
1.051e-02	-4.56	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	48	APOE
1.051e-02	-4.56	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	48	ATP1A2
1.053e-02	-4.55	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	4	16828	48	SPAG16,GPC5,NKAIN3,IGSF11
1.061e-02	-4.55	GATA3 (GATA binding protein 3)	protein interactions	2625	177	3	19454	50	NFIA,QKI,TRPS1
1.067e-02	-4.54	GPROTEINAQ	prints domains	PR00442	4	1	5227	14	GNA14
1.076e-02	-4.53	PLC-beta	interpro domains	IPR016280	4	1	18521	50	PLCB4
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.076e-02	-4.53	PLC-beta_C_sf	interpro domains	IPR042531	4	1	18521	50	PLCB4
1.076e-02	-4.53	ApoA_E	interpro domains	IPR000074	4	1	18521	50	APOE
1.076e-02	-4.53	PKHA4-7_PH	interpro domains	IPR040392	4	1	18521	50	PLEKHA7
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	PLC-beta_PH	interpro domains	IPR037862	4	1	18521	50	PLCB4
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	Gprotein_alpha_Q	interpro domains	IPR000654	4	1	18521	50	GNA14
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	TFR-like_dimer_dom	interpro domains	IPR007365	4	1	18521	50	FOLH1
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	FGF_rcpt_fam	interpro domains	IPR016248	4	1	18521	50	FGFR2
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	TNIK,IRAG1
1.077e-02	-4.53	CBY1 (chibby 1, beta catenin antagonist)	protein interactions	25776	178	3	19454	50	CLU,PLEKHA7,ABLIM1
1.085e-02	-4.52	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	46	FGFR2,MERTK
1.087e-02	-4.52	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	32	SLC1A3,SLC1A2
1.097e-02	-4.51	TRPM_tetra	pfam domains	PF16519	4	1	17795	49	TRPM3
1.097e-02	-4.51	Apolipoprotein	pfam domains	PF01442	4	1	17795	49	APOE
1.097e-02	-4.51	PH_14	pfam domains	PF17787	4	1	17795	49	PLCB4
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	TFR_dimer	pfam domains	PF04253	4	1	17795	49	FOLH1
1.097e-02	-4.51	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	49	NFIA
1.097e-02	-4.51	Suppressor_APC	pfam domains	PF11414	4	1	17795	49	APC
1.097e-02	-4.51	P5-ATPase	pfam domains	PF12409	4	1	17795	49	ATP13A4
1.097e-02	-4.51	CTF_NFI	pfam domains	PF00859	4	1	17795	49	NFIA
1.097e-02	-4.51	AbLIM_anchor	pfam domains	PF16182	4	1	17795	49	ABLIM1
1.106e-02	-4.50	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	46	16828	48	ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1,ARHGEF26,TTC28,CTNND2,ATP10B,GRAMD1C,GULP1,CDC14A,SLC1A2,PLCB4,MERTK,QKI,RFX4,ZNRF3,FOLH1,PITPNC1,TRPM3,GLI3,RPE65,DAAM2,GPC5,SPAG16,ATP1A2,NPAS3,NFIA,GNA14,APC,PDLIM5,LUZP2,PREX2,ATP13A4,GLIS3,MSI2,CLU,SLC1A3,LSAMP,IGSF11,TNIK,LRIG1,FGFR2,PTPRZ1,MAML2
1.106e-02	-4.50	bladder	COSMIC cancer mutations	bladder	14112	46	16828	48	ATP10B,SLC1A2,PLCB4,GULP1,GRAMD1C,CDC14A,FNBP1,TRPS1,ITPR2,PLEKHA7,ABLIM1,CTNND2,TTC28,ARHGEF26,DAAM2,GPC5,SPAG16,RPE65,NPAS3,ATP1A2,QKI,ZNRF3,RFX4,MERTK,GLI3,TRPM3,PITPNC1,FOLH1,PREX2,LUZP2,GLIS3,ATP13A4,MSI2,NFIA,APC,GNA14,PDLIM5,TNIK,LRIG1,IGSF11,MAML2,FGFR2,PTPRZ1,LSAMP,SLC1A3,CLU
1.107e-02	-4.50	MamL-1	smart domains	SM01275	3	1	9717	36	MAML2
1.111e-02	-4.50	asymmetric synapse	cellular component	GO:0032279	333	4	19108	50	PDLIM5,IGSF11,CTNND2,TNIK
1.120e-02	-4.49	cell adhesion	biological process	GO:0007155	942	7	18204	48	APC,CTNND2,MERTK,PDLIM5,PLEKHA7,LSAMP,IGSF11
1.134e-02	-4.48	IGc2	smart domains	SM00408	239	4	9717	36	IGSF11,LRIG1,LSAMP,FGFR2
1.136e-02	-4.48	thymus-carcinoid-endocrine_tumour	COSMIC cancer mutations	thymus-carcinoid-endocrine_tumour	4	1	16828	48	APC
1.136e-02	-4.48	central_nervous_system-cerebellum-other-liponeurocytoma	COSMIC cancer mutations	central_nervous_system-cerebellum-other-liponeurocytoma	4	1	16828	48	APC
1.136e-02	-4.48	large_intestine-colon-other-ulcerative_colitis	COSMIC cancer mutations	large_intestine-colon-other-ulcerative_colitis	4	1	16828	48	APC
1.136e-02	-4.48	soft_tissue-fibrous_tissue_and_uncertain_origin-synovial_sarcoma-poorly_differentiated	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-synovial_sarcoma-poorly_differentiated	4	1	16828	48	APC
1.136e-02	-4.48	poorly_differentiated	COSMIC cancer mutations	poorly_differentiated	4	1	16828	48	APC
1.136e-02	-4.48	aberrant_crypt_foci	COSMIC cancer mutations	aberrant_crypt_foci	4	1	16828	48	APC
1.136e-02	-4.48	juvenile_polyp	COSMIC cancer mutations	juvenile_polyp	4	1	16828	48	APC
1.136e-02	-4.48	haematopoietic_and_lymphoid_tissue-mediastinum-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-mediastinum-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	4	1	16828	48	APC
1.136e-02	-4.48	large_intestine-colon-serrated_polyp-hyperplastic_polyp	COSMIC cancer mutations	large_intestine-colon-serrated_polyp-hyperplastic_polyp	4	1	16828	48	APC
1.136e-02	-4.48	bone-frontal-other-ameloblastoma	COSMIC cancer mutations	bone-frontal-other-ameloblastoma	4	1	16828	48	FGFR2
1.136e-02	-4.48	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	48	PREX2
1.136e-02	-4.48	large_intestine-other-hamartoma	COSMIC cancer mutations	large_intestine-other-hamartoma	4	1	16828	48	APC
1.136e-02	-4.48	fibrous_dysplasia	COSMIC cancer mutations	fibrous_dysplasia	4	1	16828	48	APC
1.136e-02	-4.48	gastrointestinal_tract_(site_indeterminate)-other-hamartoma	COSMIC cancer mutations	gastrointestinal_tract_(site_indeterminate)-other-hamartoma	4	1	16828	48	APC
1.136e-02	-4.48	urinary_tract-bladder-other-normal	COSMIC cancer mutations	urinary_tract-bladder-other-normal	4	1	16828	48	APC
1.136e-02	-4.48	large_intestine-caecum-adenoma-tubular	COSMIC cancer mutations	large_intestine-caecum-adenoma-tubular	4	1	16828	48	APC
1.136e-02	-4.48	soft_tissue-fibrous_tissue_and_uncertain_origin-juvenile_angiofibroma	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-juvenile_angiofibroma	4	1	16828	48	APC
1.136e-02	-4.48	central_nervous_system-glioma-ependymoma	COSMIC cancer mutations	central_nervous_system-glioma-ependymoma	4	1	16828	48	APC
1.136e-02	-4.48	large_intestine-colon-carcinoma-neuroendocrine_carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma-neuroendocrine_carcinoma	4	1	16828	48	APC
1.136e-02	-4.48	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	48	PREX2
1.136e-02	-4.48	juvenile_angiofibroma	COSMIC cancer mutations	juvenile_angiofibroma	4	1	16828	48	APC
1.136e-02	-4.48	liponeurocytoma	COSMIC cancer mutations	liponeurocytoma	4	1	16828	48	APC
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.143e-02	-4.47	human chr3q13.32	chromosome location	human chr3q13.32	6	1	26134	50	IGSF11
1.148e-02	-4.47	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	6	18094	46	ATP1A2,ITPR2,SLC1A2,SLC1A3,TRPM3,ATP13A4
1.151e-02	-4.46	thyroid-adenoma-nodule-goitre	COSMIC cancer mutations	thyroid-adenoma-nodule-goitre	57	2	16828	48	APC,FGFR2
1.153e-02	-4.46	phospholipid transporter activity	molecular function	GO:0005548	64	2	18094	46	PITPNC1,ATP10B
1.160e-02	-4.46	camera-type eye development	biological process	GO:0043010	335	4	18204	48	MERTK,NFIA,GLI3,RPE65
1.171e-02	-4.45	Metabolism of fat-soluble vitamins	REACTOME pathways	R-HSA-6806667	53	2	10285	32	APOE,GPC5
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	TRPS1,NFIA
1.179e-02	-4.44	SYNC (syncoilin, intermediate filament protein)	protein interactions	81493	64	2	19454	50	APC,MAML2
1.181e-02	-4.44	Tyr_Pase_cat	interpro domains	IPR003595	61	2	18521	50	CDC14A,PTPRZ1
1.184e-02	-4.44	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	43	TRPM3
1.184e-02	-4.44	-	gene3d domains	2.30.29.240	4	1	14470	43	PLCB4
1.184e-02	-4.44	Phospholipase C beta, distal C-terminal domain	gene3d domains	1.20.1230.10	4	1	14470	43	PLCB4
1.184e-02	-4.44	-	gene3d domains	6.10.140.470	4	1	14470	43	FNBP1
1.190e-02	-4.43	haematopoietic_and_lymphoid_tissue-skin-haematopoietic_neoplasm-blastic_plasmacytoid_dendritic_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-skin-haematopoietic_neoplasm-blastic_plasmacytoid_dendritic_cell_neoplasm	58	2	16828	48	FGFR2,APC
1.198e-02	-4.42	peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	peripheral_T_cell_lymphoma_unspecified	167	3	16828	48	ITPR2,APC,TTC28
1.200e-02	-4.42	regulation of nitric oxide biosynthetic process	biological process	GO:0045428	63	2	18204	48	CLU,APOE
1.213e-02	-4.41	Basal cell carcinoma	KEGG pathways	hsa05217	55	2	7161	22	APC,GLI3
1.213e-02	-4.41	Basal cell carcinoma	KEGG pathways	ko05217	55	2	7161	22	GLI3,APC
1.223e-02	-4.40	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	46	SLC1A3,SLC1A2
1.230e-02	-4.40	KLF5 (KLF transcription factor 5)	protein interactions	688	187	3	19454	50	CLU,NFIA,TRPS1
1.232e-02	-4.40	cilium assembly	biological process	GO:0060271	341	4	18204	48	SPAG16,RFX4,ABLIM1,CDC14A
1.237e-02	-4.39	dendrite morphogenesis	biological process	GO:0048813	64	2	18204	48	CTNND2,PREX2
1.237e-02	-4.39	cranial nerve development	biological process	GO:0021545	64	2	18204	48	GLI3,SLC1A3
1.247e-02	-4.38	head_neck	COSMIC cancer mutations	head_neck	15361	48	16828	48	APOE,TTC28,CTNND2,ARHGEF26,TRPS1,FNBP1,ABLIM1,PLEKHA7,ITPR2,PLCB4,SLC1A2,CDC14A,GRAMD1C,GULP1,ATP10B,PITPNC1,TRPM3,GLI3,FOLH1,RFX4,ZNRF3,QKI,MERTK,NPAS3,ATP1A2,SPAG16,GPC5,DAAM2,RPE65,NKAIN3,PDLIM5,GNA14,APC,NFIA,MSI2,GLIS3,ATP13A4,PREX2,LUZP2,SLC1A3,LSAMP,CLU,MAML2,PTPRZ1,FGFR2,LRIG1,TNIK,IGSF11
1.250e-02	-4.38	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	2	19454	50	APOE,CLU
1.250e-02	-4.38	NFATC2IP (nuclear factor of activated T cells 2 interacting protein)	protein interactions	84901	66	2	19454	50	DAAM2,PDLIM5
1.250e-02	-4.38	MAML1 (mastermind like transcriptional coactivator 1)	protein interactions	9794	66	2	19454	50	NFIA,MAML2
1.253e-02	-4.38	postsynaptic specialization	cellular component	GO:0099572	345	4	19108	50	TNIK,PDLIM5,CTNND2,IGSF11
1.257e-02	-4.38	excitatory synapse	cellular component	GO:0060076	65	2	19108	50	IGSF11,FGFR2
1.260e-02	-4.37	monoatomic ion transport	biological process	GO:0006811	964	7	18204	48	PLCB4,ATP13A4,ITPR2,SLC1A2,SLC1A3,TRPM3,ATP1A2
1.262e-02	-4.37	Ig-like_fold	interpro domains	IPR013783	721	6	18521	50	LSAMP,FGFR2,MERTK,PTPRZ1,IGSF11,LRIG1
1.265e-02	-4.37	phosphatidylcholine flippase activity	molecular function	GO:0140345	5	1	18094	46	ATP10B
1.265e-02	-4.37	fibroblast growth factor receptor activity	molecular function	GO:0005007	5	1	18094	46	FGFR2
1.269e-02	-4.37	central_nervous_system-spinal_cord-atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	central_nervous_system-spinal_cord-atypical_teratoid-rhabdoid_tumour	60	2	16828	48	FGFR2,APC
1.274e-02	-4.36	cell junction organization	biological process	GO:0034330	532	5	18204	48	NFIA,PLEKHA7,APC,APOE,CTNND2
1.274e-02	-4.36	regulation of nitric oxide metabolic process	biological process	GO:0080164	65	2	18204	48	CLU,APOE
1.278e-02	-4.36	sensory perception of mechanical stimulus	biological process	GO:0050954	185	3	18204	48	SLC1A3,LRIG1,CDC14A
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	Axin1 (axin 1)	protein interactions	79257	5	1	19454	50	APC
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	CHRM1 (cholinergic receptor muscarinic 1)	protein interactions	1128	5	1	19454	50	CDC14A
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.291e-02	-4.35	VIRMA (vir like m6A methyltransferase associated)	protein interactions	25962	2914	14	19454	50	CLU,ARHGEF26,TTC28,TNIK,ZNRF3,ITPR2,GLI3,ABLIM1,TRPS1,CDC14A,FNBP1,MAML2,APC,PLEKHA7
1.298e-02	-4.34	ARM-type_fold	interpro domains	IPR016024	338	4	18521	50	APC,ITPR2,CTNND2,DAAM2
1.301e-02	-4.34	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	2	10285	32	ITPR2,ATP1A2
1.302e-02	-4.34	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	50	CLU
1.308e-02	-4.34	lung-carcinoid-endocrine_tumour-typical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-typical	321	4	16828	48	TRPS1,APC,FGFR2,PTPRZ1
1.308e-02	-4.34	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	4	16828	48	FOLH1,ATP1A2,LRIG1,CTNND2
1.308e-02	-4.34	typical	COSMIC cancer mutations	typical	321	4	16828	48	TRPS1,FGFR2,APC,PTPRZ1
1.310e-02	-4.34	thyroid-carcinoma-follicular_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-follicular_carcinoma	61	2	16828	48	APC,FGFR2
1.310e-02	-4.34	Langerhans_cell_histiocytosis	COSMIC cancer mutations	Langerhans_cell_histiocytosis	61	2	16828	48	APC,FGFR2
1.310e-02	-4.34	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Langerhans_cell_histiocytosis	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Langerhans_cell_histiocytosis	61	2	16828	48	APC,FGFR2
1.310e-02	-4.34	follicular_carcinoma	COSMIC cancer mutations	follicular_carcinoma	61	2	16828	48	APC,FGFR2
1.312e-02	-4.33	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	48	APOE
1.312e-02	-4.33	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	48	APOE
1.312e-02	-4.33	mesenchymal cell proliferation involved in lung development	biological process	GO:0060916	5	1	18204	48	FGFR2
1.312e-02	-4.33	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	48	APOE
1.312e-02	-4.33	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	48	CLU
1.312e-02	-4.33	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	48	APOE
1.312e-02	-4.33	epithelial cell proliferation involved in salivary gland morphogenesis	biological process	GO:0060664	5	1	18204	48	FGFR2
1.312e-02	-4.33	amygdala development	biological process	GO:0021764	5	1	18204	48	ATP1A2
1.312e-02	-4.33	positive regulation of epithelial cell proliferation involved in lung morphogenesis	biological process	GO:0060501	5	1	18204	48	FGFR2
1.312e-02	-4.33	regulation of apoptotic process in bone marrow cell	biological process	GO:0071865	5	1	18204	48	FGFR2
1.312e-02	-4.33	otolith morphogenesis	biological process	GO:0032474	5	1	18204	48	LRIG1
1.312e-02	-4.33	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	48	SLC1A3,SLC1A2
1.323e-02	-4.33	kidney	COSMIC cancer mutations	kidney	15380	48	16828	48	MSI2,ATP13A4,GLIS3,LUZP2,PREX2,PDLIM5,GNA14,APC,NFIA,PTPRZ1,FGFR2,MAML2,IGSF11,LRIG1,TNIK,CLU,LSAMP,SLC1A3,CDC14A,GULP1,GRAMD1C,PLCB4,SLC1A2,ATP10B,ARHGEF26,APOE,CTNND2,TTC28,PLEKHA7,ABLIM1,ITPR2,TRPS1,FNBP1,ATP1A2,NPAS3,NKAIN3,RPE65,SPAG16,DAAM2,GPC5,FOLH1,GLI3,PITPNC1,TRPM3,MERTK,ZNRF3,RFX4,QKI
1.328e-02	-4.32	phosphoric ester hydrolase activity	molecular function	GO:0042578	362	4	18094	46	PLCB4,ATP1A2,CDC14A,PTPRZ1
1.331e-02	-4.32	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	8	16828	48	ATP10B,TNIK,PDLIM5,APC,FGFR2,MAML2,PLCB4,CTNND2
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.333e-02	-4.32	PITRANSFER	prints domains	PR00391	5	1	5227	14	PITPNC1
1.339e-02	-4.31	PHIP (pleckstrin homology domain interacting protein)	protein interactions	55023	193	3	19454	50	CLU,GLI3,TRPS1
1.339e-02	-4.31	CTF_NFI_2	prosite domains	PS51080	4	1	12186	41	NFIA
1.339e-02	-4.31	CTF_NFI_1	prosite domains	PS00349	4	1	12186	41	NFIA
1.341e-02	-4.31	Alzheimer's disease	KEGG pathways	ko05010	165	3	7161	22	APOE,PLCB4,ITPR2
1.341e-02	-4.31	Alzheimer's disease	KEGG pathways	hsa05010	165	3	7161	22	ITPR2,APOE,PLCB4
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	Aminotrans_3	interpro domains	IPR005814	5	1	18521	50	ETNPPL
1.343e-02	-4.31	Aminotrans_3_PPA_site	interpro domains	IPR049704	5	1	18521	50	ETNPPL
1.343e-02	-4.31	BBP-like	interpro domains	IPR045071	5	1	18521	50	QKI
1.350e-02	-4.31	cholesterol transport	biological process	GO:0030301	67	2	18204	48	APOE,CLU
1.351e-02	-4.30	Ectoderm Differentiation	WikiPathways	WP2858	143	3	5310	19	FGFR2,GLI3,CTNND2
1.354e-02	-4.30	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	6	19454	50	SLC1A2,MERTK,FGFR2,CLU,PLEKHA7,MSI2
1.358e-02	-4.30	small_intestine-carcinoid-endocrine_tumour	COSMIC cancer mutations	small_intestine-carcinoid-endocrine_tumour	175	3	16828	48	APC,FGFR2,TNIK
1.359e-02	-4.30	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	46	16828	48	FGFR2,PTPRZ1,MAML2,IGSF11,TNIK,LRIG1,CLU,SLC1A3,LSAMP,GLIS3,ATP13A4,LUZP2,PREX2,APC,GNA14,PDLIM5,NFIA,ATP1A2,NPAS3,RPE65,NKAIN3,GPC5,DAAM2,SPAG16,FOLH1,PITPNC1,TRPM3,GLI3,MERTK,QKI,RFX4,ZNRF3,GRAMD1C,GULP1,CDC14A,SLC1A2,PLCB4,ATP10B,ARHGEF26,TTC28,CTNND2,ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1
1.361e-02	-4.30	MARCHF1 (membrane associated ring-CH-type finger 1)	protein interactions	55016	69	2	19454	50	ZNRF3,FGFR2
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.369e-02	-4.29	Aminotran_3	pfam domains	PF00202	5	1	17795	49	ETNPPL
1.399e-02	-4.27	MTMR9 (myotubularin related protein 9)	protein interactions	66036	70	2	19454	50	CLU,FGFR2
1.403e-02	-4.27	system process	biological process	GO:0003008	2015	11	18204	48	SPAG16,PDLIM5,PTPRZ1,APOE,ATP1A2,SLC1A2,SLC1A3,LRIG1,RPE65,ABLIM1,CDC14A
1.408e-02	-4.26	IG_LIKE	prosite domains	PS50835	430	5	12186	41	MERTK,LRIG1,IGSF11,FGFR2,LSAMP
1.418e-02	-4.26	large_intestine-caecum-serrated_polyp-serrated_adenoma	COSMIC cancer mutations	large_intestine-caecum-serrated_polyp-serrated_adenoma	5	1	16828	48	APC
1.418e-02	-4.26	admixed_hyperplastic_polyp-adenoma	COSMIC cancer mutations	admixed_hyperplastic_polyp-adenoma	5	1	16828	48	APC
1.418e-02	-4.26	stomach-other-dysplasia	COSMIC cancer mutations	stomach-other-dysplasia	5	1	16828	48	APC
1.418e-02	-4.26	cemento-ossifying_fibroma	COSMIC cancer mutations	cemento-ossifying_fibroma	5	1	16828	48	APC
1.418e-02	-4.26	frontal	COSMIC cancer mutations	frontal	5	1	16828	48	FGFR2
1.418e-02	-4.26	central_nervous_system-glioma-ependymoma_Grade_II	COSMIC cancer mutations	central_nervous_system-glioma-ependymoma_Grade_II	5	1	16828	48	APC
1.418e-02	-4.26	large_intestine-adenoma-villous	COSMIC cancer mutations	large_intestine-adenoma-villous	5	1	16828	48	APC
1.418e-02	-4.26	malignant_histiocytosis	COSMIC cancer mutations	malignant_histiocytosis	5	1	16828	48	APC
1.418e-02	-4.26	large_intestine-rectum-serrated_polyp-serrated_adenoma	COSMIC cancer mutations	large_intestine-rectum-serrated_polyp-serrated_adenoma	5	1	16828	48	APC
1.418e-02	-4.26	bone-osteosarcoma-chondroblastic	COSMIC cancer mutations	bone-osteosarcoma-chondroblastic	5	1	16828	48	APC
1.418e-02	-4.26	Peutz-Jeghers_polyp	COSMIC cancer mutations	Peutz-Jeghers_polyp	5	1	16828	48	APC
1.418e-02	-4.26	large_intestine-rectum-carcinoid-endocrine_tumour	COSMIC cancer mutations	large_intestine-rectum-carcinoid-endocrine_tumour	5	1	16828	48	APC
1.418e-02	-4.26	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	48	PREX2
1.418e-02	-4.26	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	5	1	16828	48	APC
1.418e-02	-4.26	large_intestine-other-neoplasm	COSMIC cancer mutations	large_intestine-other-neoplasm	5	1	16828	48	APC
1.418e-02	-4.26	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-malignant_histiocytosis	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-malignant_histiocytosis	5	1	16828	48	APC
1.430e-02	-4.25	IG	smart domains	SM00409	394	5	9717	36	LRIG1,IGSF11,FGFR2,LSAMP,MERTK
1.432e-02	-4.25	Long-term depression	KEGG pathways	hsa04730	60	2	7161	22	PLCB4,ITPR2
1.432e-02	-4.25	Long-term depression	KEGG pathways	ko04730	60	2	7161	22	PLCB4,ITPR2
1.435e-02	-4.24	adenoma-nodule-goitre	COSMIC cancer mutations	adenoma-nodule-goitre	64	2	16828	48	APC,FGFR2
1.440e-02	-4.24	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	8	16828	48	TNIK,ATP10B,PDLIM5,FGFR2,APC,PLCB4,MAML2,CTNND2
1.440e-02	-4.24	membrane organization	biological process	GO:0061024	761	6	18204	48	GRAMD1C,ATP10B,APOE,PITPNC1,GULP1,CLU
1.441e-02	-4.24	the visual cycle I (vertebrates)	BIOCYC pathways	META_PWY-6861	13	1	902	1	RPE65
1.446e-02	-4.24	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	19	ATP1A2,SLC1A3
1.447e-02	-4.24	Signal Transduction	REACTOME pathways	R-HSA-162582	2547	14	10285	32	GNA14,GPC5,ZNRF3,LRIG1,PLCB4,APOE,FGFR2,GLI3,APC,RPE65,CDC14A,ITPR2,ARHGEF26,MAML2
1.449e-02	-4.23	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	10	16828	48	PREX2,QKI,ABLIM1,GLI3,CTNND2,FOLH1,PTPRZ1,CDC14A,FGFR2,APC
1.449e-02	-4.23	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	10	16828	48	PREX2,QKI,ABLIM1,GLI3,CTNND2,FOLH1,PTPRZ1,CDC14A,FGFR2,APC
1.451e-02	-4.23	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	50	FNBP1,CLU,ABLIM1,TNIK
1.453e-02	-4.23	NUP107 (nucleoporin 107)	protein interactions	57122	199	3	19454	50	APC,ITPR2,GLI3
1.468e-02	-4.22	regulation of localization	biological process	GO:0032879	2028	11	18204	48	GPC5,PLCB4,APOE,APC,GLI3,CLU,MERTK,ATP1A2,NKAIN3,SLC1A2,ITPR2
1.470e-02	-4.22	inner ear development	biological process	GO:0048839	195	3	18204	48	LRIG1,GLI3,FGFR2
1.477e-02	-4.22	PH	pfam domains	PF00169	187	3	17795	49	ARHGEF26,PREX2,PLEKHA7
1.477e-02	-4.22	-	gene3d domains	1.20.5.10	5	1	14470	43	APC
1.477e-02	-4.22	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	43	APOE
1.477e-02	-4.22	Formin, FH3 diaphanous domain	gene3d domains	1.10.238.150	5	1	14470	43	DAAM2
1.478e-02	-4.21	maxilla	COSMIC cancer mutations	maxilla	65	2	16828	48	FGFR2,APC
1.482e-02	-4.21	Alzheimers Disease	WikiPathways	WP2059	148	3	5310	19	PLCB4,ITPR2,APOE
1.484e-02	-4.21	monoatomic cation transport	biological process	GO:0006812	766	6	18204	48	TRPM3,ATP1A2,SLC1A3,PLCB4,ATP13A4,ITPR2
1.492e-02	-4.21	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	3	19454	50	PLEKHA7,ATP1A2,DAAM2
1.511e-02	-4.19	locomotory behavior	biological process	GO:0007626	197	3	18204	48	PREX2,APOE,ATP1A2
1.512e-02	-4.19	neuron to neuron synapse	cellular component	GO:0098984	365	4	19108	50	PDLIM5,CTNND2,IGSF11,TNIK
1.516e-02	-4.19	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	46	APOE
1.516e-02	-4.19	steroid hormone binding	molecular function	GO:1990239	6	1	18094	46	ATP1A2
1.528e-02	-4.18	neoplasm	COSMIC cancer mutations	neoplasm	14787	47	16828	48	PREX2,LUZP2,MSI2,GLIS3,ATP13A4,NFIA,PDLIM5,APC,GNA14,LRIG1,TNIK,IGSF11,MAML2,PTPRZ1,FGFR2,LSAMP,SLC1A3,CLU,ATP10B,PLCB4,SLC1A2,CDC14A,GULP1,GRAMD1C,TRPS1,FNBP1,PLEKHA7,ABLIM1,ITPR2,APOE,CTNND2,TTC28,ARHGEF26,SPAG16,DAAM2,GPC5,NKAIN3,RPE65,NPAS3,ATP1A2,ZNRF3,RFX4,QKI,MERTK,GLI3,TRPM3,FOLH1
1.529e-02	-4.18	alveolar	COSMIC cancer mutations	alveolar	2414	13	16828	48	NPAS3,FGFR2,PREX2,APOE,TRPM3,SLC1A3,TTC28,CLU,FOLH1,PDLIM5,ZNRF3,NFIA,TRPS1
1.529e-02	-4.18	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	13	16828	48	APOE,SLC1A3,TRPM3,TTC28,CLU,PDLIM5,FOLH1,ZNRF3,NFIA,TRPS1,NPAS3,FGFR2,PREX2
1.532e-02	-4.18	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	50	APOE
1.532e-02	-4.18	FGF23 (fibroblast growth factor 23)	protein interactions	8074	6	1	19454	50	FGFR2
1.532e-02	-4.18	FGF6 (fibroblast growth factor 6)	protein interactions	2251	6	1	19454	50	FGFR2
1.532e-02	-4.18	SSPOP (SCO-spondin, pseudogene)	protein interactions	23145	6	1	19454	50	TTC28
1.532e-02	-4.18	RSPO3 (R-spondin 3)	protein interactions	84870	6	1	19454	50	ZNRF3
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	FGF18 (fibroblast growth factor 18)	protein interactions	8817	6	1	19454	50	FGFR2
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	DAZ4 (deleted in azoospermia 4)	protein interactions	57135	6	1	19454	50	QKI
1.532e-02	-4.18	PBP2 (Pbp2p)	protein interactions	852533	6	1	19454	50	QKI
1.532e-02	-4.18	Hdac1 (histone deacetylase 1)	protein interactions	433759	6	1	19454	50	FOLH1
1.532e-02	-4.18	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	50	APOE
1.535e-02	-4.18	DH-domain	interpro domains	IPR000219	70	2	18521	50	PREX2,ARHGEF26
1.538e-02	-4.17	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	26	16828	48	GLI3,TRPM3,PITPNC1,CLU,ZNRF3,RFX4,MERTK,MAML2,PTPRZ1,FGFR2,ATP1A2,SPAG16,LRIG1,TNIK,GPC5,CTNND2,TTC28,PDLIM5,APC,NFIA,ABLIM1,ITPR2,PLCB4,ATP13A4,PREX2,ATP10B
1.538e-02	-4.17	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	26	16828	48	LRIG1,SPAG16,TNIK,GPC5,PTPRZ1,FGFR2,ATP1A2,MAML2,MERTK,ZNRF3,RFX4,CLU,GLI3,TRPM3,PITPNC1,PREX2,ATP10B,PLCB4,ATP13A4,ABLIM1,ITPR2,NFIA,PDLIM5,APC,CTNND2,TTC28
1.548e-02	-4.17	stem cell proliferation	biological process	GO:0072089	72	2	18204	48	ZNRF3,GLI3
1.550e-02	-4.17	LIM	pfam domains	PF00412	69	2	17795	49	PDLIM5,ABLIM1
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	APC,ARHGEF26,ABLIM1
1.560e-02	-4.16	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	50	APOE
1.562e-02	-4.16	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	25	16828	48	ATP13A4,GLIS3,CDC14A,ATP10B,PREX2,LUZP2,APC,GNA14,NFIA,TRPS1,ITPR2,ABLIM1,PLEKHA7,ATP1A2,FGFR2,PTPRZ1,GPC5,LRIG1,RPE65,TRPM3,SLC1A3,GLI3,CLU,RFX4,MERTK
1.566e-02	-4.16	blastic_plasmacytoid_dendritic_cell_neoplasm	COSMIC cancer mutations	blastic_plasmacytoid_dendritic_cell_neoplasm	67	2	16828	48	APC,FGFR2
1.569e-02	-4.16	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	25	16828	48	SLC1A3,TRPM3,GLI3,CLU,RFX4,MERTK,ATP1A2,FGFR2,PTPRZ1,GPC5,LRIG1,RPE65,APC,GNA14,TRPS1,NFIA,ITPR2,ABLIM1,PLEKHA7,ATP13A4,GLIS3,CDC14A,ATP10B,PREX2,LUZP2
1.572e-02	-4.15	positive regulation of cell proliferation in bone marrow	biological process	GO:0071864	6	1	18204	48	FGFR2
1.572e-02	-4.15	forebrain neuroblast division	biological process	GO:0021873	6	1	18204	48	FGFR2
1.572e-02	-4.15	C-terminal protein deglutamylation	biological process	GO:0035609	6	1	18204	48	FOLH1
1.572e-02	-4.15	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	48	CLU
1.572e-02	-4.15	branching morphogenesis of a nerve	biological process	GO:0048755	6	1	18204	48	FGFR2
1.572e-02	-4.15	optic nerve morphogenesis	biological process	GO:0021631	6	1	18204	48	GLI3
1.572e-02	-4.15	neutrophil clearance	biological process	GO:0097350	6	1	18204	48	MERTK
1.572e-02	-4.15	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	biological process	GO:0060527	6	1	18204	48	FGFR2
1.572e-02	-4.15	forebrain ventricular zone progenitor cell division	biological process	GO:0021869	6	1	18204	48	FGFR2
1.572e-02	-4.15	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	48	SLC1A3
1.572e-02	-4.15	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	48	APOE
1.572e-02	-4.15	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	48	APOE
1.572e-02	-4.15	prostate glandular acinus morphogenesis	biological process	GO:0060526	6	1	18204	48	FGFR2
1.576e-02	-4.15	DBL_dom_sf	interpro domains	IPR035899	71	2	18521	50	ARHGEF26,PREX2
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	ABLIM1,PDLIM5
1.584e-02	-4.15	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	47	16828	48	TRPM3,PITPNC1,GLI3,FOLH1,QKI,RFX4,ZNRF3,MERTK,NPAS3,ATP1A2,GPC5,DAAM2,SPAG16,RPE65,NKAIN3,TTC28,CTNND2,APOE,ARHGEF26,FNBP1,TRPS1,ITPR2,ABLIM1,PLEKHA7,SLC1A2,PLCB4,GRAMD1C,GULP1,CDC14A,ATP10B,SLC1A3,LSAMP,CLU,MAML2,FGFR2,PTPRZ1,TNIK,LRIG1,IGSF11,APC,GNA14,PDLIM5,NFIA,ATP13A4,GLIS3,PREX2,LUZP2
1.584e-02	-4.15	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	47	16828	48	PDLIM5,APC,GNA14,NFIA,GLIS3,ATP13A4,PREX2,LUZP2,LSAMP,SLC1A3,CLU,MAML2,PTPRZ1,FGFR2,LRIG1,TNIK,IGSF11,APOE,CTNND2,TTC28,ARHGEF26,TRPS1,FNBP1,PLEKHA7,ABLIM1,ITPR2,PLCB4,SLC1A2,CDC14A,GULP1,GRAMD1C,ATP10B,GLI3,TRPM3,PITPNC1,FOLH1,ZNRF3,RFX4,QKI,MERTK,NPAS3,ATP1A2,SPAG16,DAAM2,GPC5,NKAIN3,RPE65
1.588e-02	-4.14	neuron fate commitment	biological process	GO:0048663	73	2	18204	48	GLI3,NFIA
1.588e-02	-4.14	regulation of cartilage development	biological process	GO:0061035	73	2	18204	48	TRPS1,GLI3
1.588e-02	-4.14	cranial skeletal system development	biological process	GO:1904888	73	2	18204	48	GLI3,FGFR2
1.589e-02	-4.14	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	7	16828	48	ATP1A2,FGFR2,APC,MERTK,ITPR2,PREX2,TNIK
1.590e-02	-4.14	Arf6 signaling events	Pathway Interaction DB	arf6_pathway	34	2	2226	13	GULP1,GNA14
1.592e-02	-4.14	RhoGEF	pfam domains	PF00621	70	2	17795	49	PREX2,ARHGEF26
1.594e-02	-4.14	CLRN2 (clarin 2)	protein interactions	645104	75	2	19454	50	LRIG1,GRAMD1C
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	ITPR2
1.609e-02	-4.13	TFR-like_dimer_dom_sf	interpro domains	IPR036757	6	1	18521	50	FOLH1
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	ITPR2
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	PH_ephexin	interpro domains	IPR047270	6	1	18521	50	ARHGEF26
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	Ephexin-like	interpro domains	IPR047271	6	1	18521	50	ARHGEF26
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	ITPR2
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	ITPR2
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	ITPR2
1.609e-02	-4.13	Peptidase_M28B	interpro domains	IPR039373	6	1	18521	50	FOLH1
1.630e-02	-4.12	positive regulation of gliogenesis	biological process	GO:0014015	74	2	18204	48	PTPRZ1,QKI
1.635e-02	-4.11	MRAP2 (melanocortin 2 receptor accessory protein 2)	protein interactions	112609	76	2	19454	50	FGFR2,ZNRF3
1.635e-02	-4.11	MIR200A (microRNA 200a)	protein interactions	406983	76	2	19454	50	MSI2,QKI
1.641e-02	-4.11	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	5	18094	46	SLC1A2,ITPR2,ATP1A2,TRPM3,SLC1A3
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	ITPR2
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	ITPR2
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	ITPR2
1.656e-02	-4.10	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	6	10285	32	ATP13A4,ATP10B,SLC1A3,ATP1A2,SLC1A2,TRPM3
1.657e-02	-4.10	positive regulation of protein catabolic process	biological process	GO:0045732	204	3	18204	48	APOE,APC,CLU
1.662e-02	-4.10	cilium organization	biological process	GO:0044782	373	4	18204	48	RFX4,CDC14A,ABLIM1,SPAG16
1.663e-02	-4.10	the visual cycle I (vertebrates)	BIOCYC pathways	HUMAN_PWY-6861	15	1	902	1	RPE65
1.667e-02	-4.09	Renin secretion	KEGG pathways	hsa04924	65	2	7161	22	PLCB4,ITPR2
1.667e-02	-4.09	Renin secretion	KEGG pathways	ko04924	65	2	7161	22	ITPR2,PLCB4
1.671e-02	-4.09	AA_TRANSFER_CLASS_3	prosite domains	PS00600	5	1	12186	41	ETNPPL
1.675e-02	-4.09	ZNF326 (zinc finger protein 326)	protein interactions	284695	210	3	19454	50	FGFR2,MERTK,NFIA
1.679e-02	-4.09	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	48	TRPM3,ITPR2,PLCB4
1.691e-02	-4.08	sarcoplasmic reticulum	cellular component	GO:0016529	76	2	19108	50	IRAG1,ITPR2
1.700e-02	-4.07	genital_tract-germ_cell_tumour-teratoma	COSMIC cancer mutations	genital_tract-germ_cell_tumour-teratoma	6	1	16828	48	APC
1.700e-02	-4.07	endometrium-carcinoma-mixed_endometrioid_and_clear_cell_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-mixed_endometrioid_and_clear_cell_carcinoma	6	1	16828	48	FGFR2
1.700e-02	-4.07	stomach-other-hamartoma	COSMIC cancer mutations	stomach-other-hamartoma	6	1	16828	48	APC
1.700e-02	-4.07	chondroblastic	COSMIC cancer mutations	chondroblastic	6	1	16828	48	APC
1.700e-02	-4.07	pancreas-carcinoid-endocrine_tumour-somatostatinoma	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour-somatostatinoma	6	1	16828	48	APC
1.700e-02	-4.07	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	48	PREX2
1.700e-02	-4.07	large_intestine-serrated_polyp-hyperplastic_polyp	COSMIC cancer mutations	large_intestine-serrated_polyp-hyperplastic_polyp	6	1	16828	48	APC
1.700e-02	-4.07	central_nervous_system-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-primitive_neuroectodermal_tumour-medulloblastoma	6	1	16828	48	APC
1.700e-02	-4.07	hyperplastic_polyp	COSMIC cancer mutations	hyperplastic_polyp	6	1	16828	48	APC
1.700e-02	-4.07	large_intestine-appendix-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-appendix-carcinoma-adenocarcinoma	6	1	16828	48	APC
1.700e-02	-4.07	liver-other-hyperplasia	COSMIC cancer mutations	liver-other-hyperplasia	6	1	16828	48	APC
1.700e-02	-4.07	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	48	PREX2
1.700e-02	-4.07	pituitary-adenoma-ACTH_non_functioning	COSMIC cancer mutations	pituitary-adenoma-ACTH_non_functioning	6	1	16828	48	APC
1.700e-02	-4.07	somatostatinoma	COSMIC cancer mutations	somatostatinoma	6	1	16828	48	APC
1.705e-02	-4.07	Tyr_Pase_AS	interpro domains	IPR016130	74	2	18521	50	PTPRZ1,CDC14A
1.709e-02	-4.07	human chr11p11.12	chromosome location	human chr11p11.12	9	1	26134	50	FOLH1
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	PDLIM5
1.709e-02	-4.07	human chr11p14.3	chromosome location	human chr11p14.3	9	1	26134	50	LUZP2
1.717e-02	-4.06	MIR34C (microRNA 34c)	protein interactions	407042	78	2	19454	50	MSI2,QKI
1.717e-02	-4.06	IFIT3 (interferon induced protein with tetratricopeptide repeats 3)	protein interactions	3437	78	2	19454	50	APOE,ATP1A2
1.717e-02	-4.06	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	50	CLU,APOE
1.718e-02	-4.06	Calcium signaling pathway	KEGG pathways	hsa04020	181	3	7161	22	PLCB4,ITPR2,GNA14
1.718e-02	-4.06	Calcium signaling pathway	KEGG pathways	ko04020	181	3	7161	22	GNA14,ITPR2,PLCB4
1.721e-02	-4.06	regulation of neurogenesis	biological process	GO:0050767	377	4	18204	48	DAAM2,GLI3,QKI,PTPRZ1
1.731e-02	-4.06	testis	COSMIC cancer mutations	testis	733	6	16828	48	FGFR2,APC,MERTK,TNIK,TRPS1,PREX2
1.744e-02	-4.05	Bile Acid Indirect Signalling Pathway	SMPDB pathways	SMP0086851	8	1	1369	3	FGFR2
1.759e-02	-4.04	PRDM1 (PR/SET domain 1)	protein interactions	639	79	2	19454	50	NFIA,TRPS1
1.759e-02	-4.04	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	26	16828	48	APC,CTNND2,TTC28,APOE,PLEKHA7,ABLIM1,FNBP1,TRPS1,CDC14A,SLC1A2,PLCB4,ATP10B,PREX2,CLU,GLI3,SLC1A3,TRPM3,PITPNC1,MERTK,QKI,RFX4,FGFR2,NPAS3,MAML2,GPC5,DAAM2
1.762e-02	-4.04	solute:sodium symporter activity	molecular function	GO:0015370	80	2	18094	46	SLC1A3,SLC1A2
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	22	PLCB4,ITPR2
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	22	PLCB4,ITPR2
1.766e-02	-4.04	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	46	PITPNC1
1.766e-02	-4.04	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	46	ATP1A2
1.766e-02	-4.04	retinyl-palmitate esterase activity	molecular function	GO:0050253	7	1	18094	46	RPE65
1.766e-02	-4.04	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	46	ATP1A2
1.770e-02	-4.03	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	43	ITPR2
1.770e-02	-4.03	Transferrin receptor-like, dimerisation domain	gene3d domains	1.20.930.40	6	1	14470	43	FOLH1
1.782e-02	-4.03	eye development	biological process	GO:0001654	381	4	18204	48	RPE65,GLI3,NFIA,MERTK
1.783e-02	-4.03	other	COSMIC cancer mutations	other	14843	47	16828	48	CLU,LSAMP,SLC1A3,PTPRZ1,FGFR2,MAML2,IGSF11,LRIG1,TNIK,PDLIM5,APC,GNA14,NFIA,MSI2,ATP13A4,GLIS3,LUZP2,PREX2,FOLH1,GLI3,TRPM3,MERTK,ZNRF3,RFX4,QKI,ATP1A2,NPAS3,NKAIN3,RPE65,SPAG16,DAAM2,GPC5,ARHGEF26,APOE,CTNND2,TTC28,PLEKHA7,ABLIM1,ITPR2,TRPS1,FNBP1,CDC14A,GULP1,GRAMD1C,PLCB4,SLC1A2,ATP10B
1.786e-02	-4.03	Pum2 (pumilio RNA-binding family member 2)	protein interactions	80913	7	1	19454	50	QKI
1.786e-02	-4.03	RP1 (RP1 axonemal microtubule associated)	protein interactions	6101	7	1	19454	50	APC
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.786e-02	-4.03	FGF5 (fibroblast growth factor 5)	protein interactions	2250	7	1	19454	50	FGFR2
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.789e-02	-4.02	cellular response to nitrogen compound	biological process	GO:1901699	580	5	18204	48	SLC1A3,SLC1A2,APC,ITPR2,GNA14
1.795e-02	-4.02	acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_T_cell_leukaemia	739	6	16828	48	FGFR2,APC,PREX2,TRPS1,ZNRF3,FNBP1
1.795e-02	-4.02	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	739	6	16828	48	APC,FGFR2,ZNRF3,TRPS1,PREX2,FNBP1
1.800e-02	-4.02	dicarboxylic acid transport	biological process	GO:0006835	78	2	18204	48	SLC1A2,SLC1A3
1.804e-02	-4.02	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	46	FGFR2,MERTK
1.828e-02	-4.00	response to oxygen-containing compound	biological process	GO:1901700	1546	9	18204	48	APOE,GNA14,ITPR2,APC,FGFR2,SLC1A3,GRAMD1C,SLC1A2,ATP1A2
1.832e-02	-4.00	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	48	PTPRZ1
1.832e-02	-4.00	bud elongation involved in lung branching	biological process	GO:0060449	7	1	18204	48	FGFR2
1.832e-02	-4.00	forebrain dorsal/ventral pattern formation	biological process	GO:0021798	7	1	18204	48	GLI3
1.832e-02	-4.00	podocyte cell migration	biological process	GO:0090521	7	1	18204	48	DAAM2
1.832e-02	-4.00	adherens junction maintenance	biological process	GO:0034334	7	1	18204	48	PLEKHA7
1.832e-02	-4.00	regulation of 3'-UTR-mediated mRNA stabilization	biological process	GO:1905868	7	1	18204	48	QKI
1.832e-02	-4.00	morphogenesis of an epithelial bud	biological process	GO:0060572	7	1	18204	48	FGFR2
1.832e-02	-4.00	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	48	APOE
1.832e-02	-4.00	glial cell fate specification	biological process	GO:0021780	7	1	18204	48	NFIA
1.832e-02	-4.00	positive regulation of transcription of Notch receptor target	biological process	GO:0007221	7	1	18204	48	MAML2
1.832e-02	-4.00	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	48	APOE
1.832e-02	-4.00	positive regulation of protein localization to centrosome	biological process	GO:1904781	7	1	18204	48	APC
1.832e-02	-4.00	cell fate specification involved in pattern specification	biological process	GO:0060573	7	1	18204	48	GLI3
1.832e-02	-4.00	hindgut morphogenesis	biological process	GO:0007442	7	1	18204	48	GLI3
1.832e-02	-4.00	lung lobe morphogenesis	biological process	GO:0060463	7	1	18204	48	FGFR2
1.832e-02	-4.00	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	48	CLU
1.832e-02	-4.00	regulation of epithelial cell proliferation involved in lung morphogenesis	biological process	GO:2000794	7	1	18204	48	FGFR2
1.832e-02	-4.00	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	48	APOE
1.832e-02	-4.00	lung lobe development	biological process	GO:0060462	7	1	18204	48	FGFR2
1.832e-02	-4.00	negative regulation of non-canonical Wnt signaling pathway	biological process	GO:2000051	7	1	18204	48	ZNRF3
1.832e-02	-4.00	ventral spinal cord interneuron specification	biological process	GO:0021521	7	1	18204	48	GLI3
1.832e-02	-4.00	lacrimal gland development	biological process	GO:0032808	7	1	18204	48	FGFR2
1.832e-02	-4.00	forebrain radial glial cell differentiation	biological process	GO:0021861	7	1	18204	48	GLI3
1.832e-02	-4.00	protein deglutamylation	biological process	GO:0035608	7	1	18204	48	FOLH1
1.832e-02	-4.00	mucociliary clearance	biological process	GO:0120197	7	1	18204	48	SPAG16
1.843e-02	-3.99	SOX17 (SRY-box transcription factor 17)	protein interactions	64321	81	2	19454	50	NFIA,TRPS1
1.844e-02	-3.99	visual system development	biological process	GO:0150063	385	4	18204	48	RPE65,GLI3,NFIA,MERTK
1.855e-02	-3.99	ORF6 (ORF6 protein)	protein interactions	43740572	825	6	19454	50	ITPR2,CLU,APC,SLC1A3,FOLH1,ABLIM1
1.861e-02	-3.98	HDAC1 (histone deacetylase 1)	protein interactions	3065	1067	7	19454	50	FOLH1,TTC28,TRPS1,PDLIM5,FNBP1,APC,GLI3
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.880e-02	-3.97	negative regulation of cell activation	biological process	GO:0050866	214	3	18204	48	MERTK,APOE,GLI3
1.883e-02	-3.97	Dbl homology (DH) domain	gene3d domains	1.20.900.10	71	2	14470	43	PREX2,ARHGEF26
1.886e-02	-3.97	GSC (goosecoid homeobox)	protein interactions	145258	82	2	19454	50	TRPS1,NFIA
1.889e-02	-3.97	genital_tract-extragonadal-germ_cell_tumour-yolk_sac_tumour	COSMIC cancer mutations	genital_tract-extragonadal-germ_cell_tumour-yolk_sac_tumour	74	2	16828	48	MERTK,APC
1.892e-02	-3.97	regulation of supramolecular fiber organization	biological process	GO:1902903	388	4	18204	48	APOE,APC,DAAM2,CLU
1.894e-02	-3.97	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	6	16828	48	CTNND2,SLC1A3,APC,FOLH1,TRPS1,ITPR2
1.896e-02	-3.97	Immunoglobulins	gene3d domains	2.60.40.10	721	6	14470	43	FGFR2,LSAMP,LRIG1,IGSF11,PTPRZ1,MERTK
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.897e-02	-3.96	human chr9q21.2	chromosome location	human chr9q21.2	10	1	26134	50	GNA14
1.897e-02	-3.96	human chr12p11.23	chromosome location	human chr12p11.23	10	1	26134	50	ITPR2
1.908e-02	-3.96	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	7	18204	48	GRAMD1C,SLC1A2,SLC1A3,GNA14,ITPR2,FGFR2,APC
1.912e-02	-3.96	TPR_7	pfam domains	PF13176	7	1	17795	49	TTC28
1.926e-02	-3.95	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	9	16828	48	FGFR2,TTC28,CTNND2,TRPM3,LSAMP,GPC5,TNIK,SPAG16,TRPS1
1.930e-02	-3.95	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	50	TRPS1,NFIA
1.932e-02	-3.95	adult locomotory behavior	biological process	GO:0008344	81	2	18204	48	ATP1A2,PREX2
1.932e-02	-3.95	regulation of amide metabolic process	biological process	GO:0034248	81	2	18204	48	APOE,CLU
1.940e-02	-3.94	sensory system development	biological process	GO:0048880	391	4	18204	48	NFIA,MERTK,RPE65,GLI3
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	MERTK,FGFR2
1.975e-02	-3.92	small molecule binding	molecular function	GO:0036094	6197	23	18094	46	RPE65,GLIS3,TNIK,TRPS1,ITPR2,ATP1A2,GRAMD1C,PLCB4,FOLH1,ABLIM1,SLC1A3,ATP13A4,ZNRF3,PDLIM5,FGFR2,GLI3,ATP10B,ETNPPL,MERTK,SLC1A2,GNA14,APOE,PITPNC1
1.980e-02	-3.92	pancreas-ampulla_of_Vater-other-adenoma	COSMIC cancer mutations	pancreas-ampulla_of_Vater-other-adenoma	7	1	16828	48	APC
1.980e-02	-3.92	large_intestine-appendix-carcinoid-endocrine_tumour	COSMIC cancer mutations	large_intestine-appendix-carcinoid-endocrine_tumour	7	1	16828	48	APC
1.980e-02	-3.92	nasal_cavity	COSMIC cancer mutations	nasal_cavity	7	1	16828	48	FGFR2
1.980e-02	-3.92	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma	7	1	16828	48	APC
1.980e-02	-3.92	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	7	1	16828	48	APC
1.980e-02	-3.92	pituitary-adenoma-multihormonal	COSMIC cancer mutations	pituitary-adenoma-multihormonal	7	1	16828	48	APC
1.980e-02	-3.92	salivary_gland-nasal_cavity-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-nasal_cavity-carcinoma-adenoid_cystic_carcinoma	7	1	16828	48	FGFR2
1.980e-02	-3.92	ulcerative_colitis	COSMIC cancer mutations	ulcerative_colitis	7	1	16828	48	APC
1.980e-02	-3.92	small_intestine-other-hamartoma	COSMIC cancer mutations	small_intestine-other-hamartoma	7	1	16828	48	APC
1.980e-02	-3.92	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	48	PREX2
1.980e-02	-3.92	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	48	PREX2
1.980e-02	-3.92	dysplastic	COSMIC cancer mutations	dysplastic	7	1	16828	48	APC
1.980e-02	-3.92	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-classic	7	1	16828	48	APC
1.980e-02	-3.92	bone-osteosarcoma-osteoblastic	COSMIC cancer mutations	bone-osteosarcoma-osteoblastic	7	1	16828	48	APC
1.980e-02	-3.92	central_nervous_system-parietal_lobe-glioma-ependymoma	COSMIC cancer mutations	central_nervous_system-parietal_lobe-glioma-ependymoma	7	1	16828	48	FOLH1
1.980e-02	-3.92	small_intestine-duodenum-adenoma	COSMIC cancer mutations	small_intestine-duodenum-adenoma	7	1	16828	48	APC
1.984e-02	-3.92	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	43	PDLIM5,ABLIM1
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	TTC28,ABLIM1,APC
2.002e-02	-3.91	GLYPICAN	prosite domains	PS01207	6	1	12186	41	GPC5
2.015e-02	-3.90	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	48	PREX2,SPAG16,ITPR2,APC,FOLH1
2.016e-02	-3.90	sodium ion binding	molecular function	GO:0031402	8	1	18094	46	ATP1A2
2.016e-02	-3.90	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	46	ATP1A2
2.016e-02	-3.90	glutamate binding	molecular function	GO:0016595	8	1	18094	46	SLC1A3
2.018e-02	-3.90	CCND3 (cyclin D3)	protein interactions	896	85	2	19454	50	CLU,QKI
2.038e-02	-3.89	ZFP14 (ZFP14 zinc finger protein)	protein interactions	57677	8	1	19454	50	MERTK
2.038e-02	-3.89	DEPP1 (DEPP autophagy regulator 1)	protein interactions	11067	8	1	19454	50	QKI
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.069e-02	-3.88	L-amino acid transport	biological process	GO:0015807	84	2	18204	48	SLC1A3,SLC1A2
2.069e-02	-3.88	hair cycle process	biological process	GO:0022405	84	2	18204	48	FGFR2,LRIG1
2.069e-02	-3.88	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	48	ATP1A2,NKAIN3
2.069e-02	-3.88	molting cycle process	biological process	GO:0022404	84	2	18204	48	LRIG1,FGFR2
2.069e-02	-3.88	ear development	biological process	GO:0043583	222	3	18204	48	FGFR2,GLI3,LRIG1
2.075e-02	-3.88	zonula adherens	cellular component	GO:0005915	8	1	19108	50	PLEKHA7
2.075e-02	-3.88	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	50	CLU
2.085e-02	-3.87	human chr5q22.2	chromosome location	human chr5q22.2	11	1	26134	50	APC
2.085e-02	-3.87	human chr3q25.2	chromosome location	human chr3q25.2	11	1	26134	50	ARHGEF26
2.086e-02	-3.87	ATP hydrolysis activity	molecular function	GO:0016887	415	4	18094	46	ATP13A4,ATP10B,CLU,ATP1A2
2.090e-02	-3.87	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	48	APOE
2.090e-02	-3.87	lateral sprouting from an epithelium	biological process	GO:0060601	8	1	18204	48	FGFR2
2.090e-02	-3.87	hindgut development	biological process	GO:0061525	8	1	18204	48	GLI3
2.090e-02	-3.87	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	48	APOE
2.090e-02	-3.87	otic vesicle formation	biological process	GO:0030916	8	1	18204	48	FGFR2
2.090e-02	-3.87	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	48	APOE
2.090e-02	-3.87	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	48	APOE
2.090e-02	-3.87	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	48	SLC1A3
2.090e-02	-3.87	vitamin A metabolic process	biological process	GO:0006776	8	1	18204	48	RPE65
2.090e-02	-3.87	membranous septum morphogenesis	biological process	GO:0003149	8	1	18204	48	FGFR2
2.090e-02	-3.87	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	48	ATP1A2
2.108e-02	-3.86	MIR141 (microRNA 141)	protein interactions	406933	87	2	19454	50	QKI,MSI2
2.108e-02	-3.86	NHLH1 (nescient helix-loop-helix 1)	protein interactions	4807	87	2	19454	50	TRPS1,NFIA
2.108e-02	-3.86	Kctd5 (potassium channel tetramerisation domain containing 5)	protein interactions	69259	87	2	19454	50	SLC1A3,TRPS1
2.115e-02	-3.86	regulation of smoothened signaling pathway	biological process	GO:0008589	85	2	18204	48	GLI3,FGFR2
2.124e-02	-3.85	GATAZNFINGER	prints domains	PR00619	8	1	5227	14	TRPS1
2.127e-02	-3.85	BICD1 (BICD cargo adaptor 1)	protein interactions	636	230	3	19454	50	TTC28,TNIK,PDLIM5
2.128e-02	-3.85	neuron projection	cellular component	GO:0043005	1331	8	19108	50	ATP1A2,CDC14A,CTNND2,SLC1A2,SLC1A3,CLU,MERTK,APOE
2.130e-02	-3.85	PTPc_motif	smart domains	SM00404	61	2	9717	36	CDC14A,PTPRZ1
2.133e-02	-3.85	stress fiber	cellular component	GO:0001725	86	2	19108	50	PDLIM5,ABLIM1
2.133e-02	-3.85	contractile actin filament bundle	cellular component	GO:0097517	86	2	19108	50	PDLIM5,ABLIM1
2.135e-02	-3.85	G alpha (q) signalling events	REACTOME pathways	R-HSA-416476	192	3	10285	32	ITPR2,GNA14,PLCB4
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	DAD_dom	interpro domains	IPR014767	8	1	18521	50	DAAM2
2.152e-02	-3.84	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	46	CLU,APOE
2.153e-02	-3.84	HSPG2 (heparan sulfate proteoglycan 2)	protein interactions	3339	88	2	19454	50	GPC5,GLI3
2.153e-02	-3.84	SCARA3 (scavenger receptor class A member 3)	protein interactions	51435	88	2	19454	50	LRIG1,GRAMD1C
2.182e-02	-3.82	VHP	pfam domains	PF02209	8	1	17795	49	ABLIM1
2.182e-02	-3.82	LSDAT_euk	pfam domains	PF18139	8	1	17795	49	TRPM3
2.196e-02	-3.82	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	3	16828	48	PLCB4,ATP13A4,APC
2.198e-02	-3.82	alcohol binding	molecular function	GO:0043178	90	2	18094	46	GRAMD1C,ITPR2
2.198e-02	-3.82	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	12	16828	48	SLC1A2,MAML2,ATP1A2,PTPRZ1,LRIG1,CTNND2,TRPM3,GLI3,APC,FOLH1,RFX4,ZNRF3
2.199e-02	-3.82	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	48	ATP1A2,PREX2,APOE,TNIK,ITPR2,IRAG1
2.199e-02	-3.82	SOX10 (SRY-box transcription factor 10)	protein interactions	6663	89	2	19454	50	TRPS1,NFIA
2.237e-02	-3.80	forearm	COSMIC cancer mutations	forearm	81	2	16828	48	APC,PREX2
2.251e-02	-3.79	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	6	16828	48	MERTK,TNIK,PDLIM5,APC,FGFR2,CTNND2
2.251e-02	-3.79	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	6	16828	48	MERTK,TNIK,APC,FGFR2,PDLIM5,CTNND2
2.257e-02	-3.79	ureteric bud development	biological process	GO:0001657	88	2	18204	48	FGFR2,GLI3
2.260e-02	-3.79	skin-neck-malignant_melanoma-nodular	COSMIC cancer mutations	skin-neck-malignant_melanoma-nodular	8	1	16828	48	APC
2.260e-02	-3.79	mixed_cell_carcinoma	COSMIC cancer mutations	mixed_cell_carcinoma	8	1	16828	48	FGFR2
2.260e-02	-3.79	skin-neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-neck-malignant_melanoma-superficial_spreading	8	1	16828	48	APC
2.260e-02	-3.79	endometrium-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-small_cell_carcinoma	8	1	16828	48	APC
2.260e-02	-3.79	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	48	PREX2
2.260e-02	-3.79	endometrium-carcinoma-mixed_cell_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-mixed_cell_carcinoma	8	1	16828	48	FGFR2
2.260e-02	-3.79	testis-germ_cell_tumour-yolk_sac_tumour	COSMIC cancer mutations	testis-germ_cell_tumour-yolk_sac_tumour	8	1	16828	48	APC
2.260e-02	-3.79	multihormonal	COSMIC cancer mutations	multihormonal	8	1	16828	48	APC
2.260e-02	-3.79	large_intestine-serrated_polyp-serrated_adenoma	COSMIC cancer mutations	large_intestine-serrated_polyp-serrated_adenoma	8	1	16828	48	APC
2.260e-02	-3.79	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	8	1	16828	48	QKI
2.260e-02	-3.79	Tyr_Pase_dom	interpro domains	IPR000387	86	2	18521	50	CDC14A,PTPRZ1
2.265e-02	-3.79	delta-catenin binding	molecular function	GO:0070097	9	1	18094	46	PLEKHA7
2.268e-02	-3.79	response to organic cyclic compound	biological process	GO:0014070	843	6	18204	48	SLC1A3,GRAMD1C,SLC1A2,ATP1A2,ITPR2,GNA14
2.272e-02	-3.78	human chr6q26	chromosome location	human chr6q26	12	1	26134	50	QKI
2.274e-02	-3.78	SAFB (scaffold attachment factor B)	protein interactions	6294	236	3	19454	50	MERTK,FGFR2,SLC1A3
2.285e-02	-3.78	inorganic cation transmembrane transport	biological process	GO:0098662	618	5	18204	48	ATP1A2,TRPM3,SLC1A3,PLCB4,ITPR2
2.288e-02	-3.78	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	9	16828	48	APC,FGFR2,FOLH1,PTPRZ1,NPAS3,LUZP2,DAAM2,GPC5,PREX2
2.289e-02	-3.78	yolk_sac_tumour	COSMIC cancer mutations	yolk_sac_tumour	82	2	16828	48	MERTK,APC
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	FGFR2
2.290e-02	-3.78	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	50	APOE
2.290e-02	-3.78	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	1	19454	50	LSAMP
2.290e-02	-3.78	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	1	19454	50	LSAMP
2.290e-02	-3.78	Ywhag (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide)	protein interactions	22628	9	1	19454	50	QKI
2.290e-02	-3.78	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	50	APOE
2.290e-02	-3.78	IL22 (interleukin 22)	protein interactions	50616	9	1	19454	50	APC
2.292e-02	-3.78	FOXI1 (forkhead box I1)	protein interactions	2299	91	2	19454	50	NFIA,TRPS1
2.305e-02	-3.77	mesonephric tubule development	biological process	GO:0072164	89	2	18204	48	GLI3,FGFR2
2.305e-02	-3.77	mesonephric epithelium development	biological process	GO:0072163	89	2	18204	48	FGFR2,GLI3
2.309e-02	-3.77	DH_2	prosite domains	PS50010	70	2	12186	41	ARHGEF26,PREX2
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	CLU,MERTK,FOLH1
2.339e-02	-3.76	RLN1 (relaxin 1)	protein interactions	6013	92	2	19454	50	GULP1,LRIG1
2.339e-02	-3.76	SOX9 (SRY-box transcription factor 9)	protein interactions	6662	92	2	19454	50	NFIA,TRPS1
2.349e-02	-3.75	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	48	ATP1A2
2.349e-02	-3.75	microglial cell proliferation	biological process	GO:0061518	9	1	18204	48	CLU
2.349e-02	-3.75	limb bud formation	biological process	GO:0060174	9	1	18204	48	FGFR2
2.349e-02	-3.75	semicircular canal development	biological process	GO:0060872	9	1	18204	48	GLI3
2.349e-02	-3.75	cranial suture morphogenesis	biological process	GO:0060363	9	1	18204	48	GLI3
2.349e-02	-3.75	sterol catabolic process	biological process	GO:0016127	9	1	18204	48	APOE
2.349e-02	-3.75	lung-associated mesenchyme development	biological process	GO:0060484	9	1	18204	48	FGFR2
2.349e-02	-3.75	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	48	APOE
2.349e-02	-3.75	regulation of cell proliferation in bone marrow	biological process	GO:0071863	9	1	18204	48	FGFR2
2.349e-02	-3.75	phospholipase C-activating dopamine receptor signaling pathway	biological process	GO:0060158	9	1	18204	48	GNA14
2.349e-02	-3.75	macrophage proliferation	biological process	GO:0061517	9	1	18204	48	CLU
2.349e-02	-3.75	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	48	ATP13A4
2.349e-02	-3.75	otic vesicle morphogenesis	biological process	GO:0071600	9	1	18204	48	FGFR2
2.349e-02	-3.75	embryonic neurocranium morphogenesis	biological process	GO:0048702	9	1	18204	48	GLI3
2.353e-02	-3.75	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	43	ABLIM1
2.371e-02	-3.74	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	41	ABLIM1,PDLIM5
2.371e-02	-3.74	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	41	PDLIM5,ABLIM1
2.387e-02	-3.74	MIR19B2 (microRNA 19b-2)	protein interactions	406981	93	2	19454	50	MSI2,QKI
2.387e-02	-3.74	DMRTB1 (DMRT like family B with proline rich C-terminal 1)	protein interactions	63948	93	2	19454	50	QKI,MSI2
2.401e-02	-3.73	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	50	CTNND2,APC,FGFR2
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	GTPase-bd	interpro domains	IPR010473	9	1	18521	50	DAAM2
2.404e-02	-3.73	FH3_dom	interpro domains	IPR010472	9	1	18521	50	DAAM2
2.410e-02	-3.73	cellular component assembly	biological process	GO:0022607	2472	12	18204	48	RFX4,APOE,TNIK,SPAG16,PLEKHA7,CLU,ABLIM1,APC,CDC14A,TRPM3,ARHGEF26,SLC1A2
2.418e-02	-3.72	actomyosin	cellular component	GO:0042641	92	2	19108	50	PDLIM5,ABLIM1
2.420e-02	-3.72	shoulder	COSMIC cancer mutations	shoulder	387	4	16828	48	APC,PDLIM5,PREX2,PLCB4
2.434e-02	-3.72	TYR_PHOSPHATASE_1	prosite domains	PS00383	72	2	12186	41	CDC14A,PTPRZ1
2.435e-02	-3.72	ZNF785 (zinc finger protein 785)	protein interactions	146540	94	2	19454	50	APC,PDLIM5
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	ABLIM1,TNIK
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CLU,CTNND2
2.452e-02	-3.71	Drf_GBD	pfam domains	PF06371	9	1	17795	49	DAAM2
2.452e-02	-3.71	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	49	RFX4
2.452e-02	-3.71	Drf_FH3	pfam domains	PF06367	9	1	17795	49	DAAM2
2.458e-02	-3.71	metal ion transport	biological process	GO:0030001	630	5	18204	48	SLC1A3,TRPM3,ATP1A2,ITPR2,PLCB4
2.463e-02	-3.70	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME pathways	R-HSA-434316	8	1	10285	32	GNA14
2.463e-02	-3.70	Free fatty acids regulate insulin secretion	REACTOME pathways	R-HSA-400451	8	1	10285	32	GNA14
2.463e-02	-3.70	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	32	GPC5
2.470e-02	-3.70	ARM-like	interpro domains	IPR011989	232	3	18521	50	CTNND2,DAAM2,APC
2.478e-02	-3.70	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	46	ATP1A2,ATP13A4
2.479e-02	-3.70	RBPJ (recombination signal binding protein for immunoglobulin kappa J region)	protein interactions	3516	244	3	19454	50	NFIA,MAML2,FNBP1
2.485e-02	-3.70	response to radiation	biological process	GO:0009314	422	4	18204	48	ATP1A2,SLC1A2,SLC1A3,RPE65
2.501e-02	-3.69	mesonephros development	biological process	GO:0001823	93	2	18204	48	FGFR2,GLI3
2.505e-02	-3.69	TAF1 (TATA-box binding protein associated factor 1)	protein interactions	6872	245	3	19454	50	GLI3,APC,ZNRF3
2.505e-02	-3.69	SCRIB (scribble planar cell polarity protein)	protein interactions	23513	245	3	19454	50	LRIG1,APC,ARHGEF26
2.514e-02	-3.68	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	46	ATP13A4
2.514e-02	-3.68	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	46	PITPNC1
2.523e-02	-3.68	developmental growth	biological process	GO:0048589	424	4	18204	48	GLI3,FGFR2,PDLIM5,SLC1A2
2.523e-02	-3.68	growth	biological process	GO:0040007	424	4	18204	48	GLI3,FGFR2,SLC1A2,PDLIM5
2.539e-02	-3.67	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	48	PREX2
2.539e-02	-3.67	hamartoma	COSMIC cancer mutations	hamartoma	9	1	16828	48	APC
2.539e-02	-3.67	extramammary	COSMIC cancer mutations	extramammary	9	1	16828	48	APC
2.539e-02	-3.67	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	48	PREX2
2.539e-02	-3.67	mixed_endometrioid_and_clear_cell_carcinoma	COSMIC cancer mutations	mixed_endometrioid_and_clear_cell_carcinoma	9	1	16828	48	FGFR2
2.539e-02	-3.67	skin-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-other-seborrhoeic_keratosis	9	1	16828	48	APC
2.539e-02	-3.67	breast-extramammary-carcinoma_in_situ-ductal_carcinoma_in_situ	COSMIC cancer mutations	breast-extramammary-carcinoma_in_situ-ductal_carcinoma_in_situ	9	1	16828	48	APC
2.539e-02	-3.67	ACTH_non_functioning	COSMIC cancer mutations	ACTH_non_functioning	9	1	16828	48	APC
2.541e-02	-3.67	Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1)	protein interactions	15519	10	1	19454	50	QKI
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	Mrpl13 (mitochondrial ribosomal protein L13)	protein interactions	68537	10	1	19454	50	QKI
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	BANK1 (B cell scaffold protein with ankyrin repeats 1)	protein interactions	55024	10	1	19454	50	ITPR2
2.541e-02	-3.67	ANGPTL3 (angiopoietin like 3)	protein interactions	27329	10	1	19454	50	GULP1
2.544e-02	-3.67	cell leading edge	cellular component	GO:0031252	428	4	19108	50	ABLIM1,APC,ARHGEF26,SLC1A2
2.547e-02	-3.67	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	7	19454	50	PITPNC1,APOE,PLEKHA7,APC,CDC14A,ABLIM1,TTC28
2.549e-02	-3.67	Regulation of insulin secretion	REACTOME pathways	R-HSA-422356	80	2	10285	32	ITPR2,GNA14
2.551e-02	-3.67	negative regulation of protein serine/threonine kinase activity	biological process	GO:0071901	94	2	18204	48	APC,APOE
2.551e-02	-3.67	embryonic skeletal system morphogenesis	biological process	GO:0048704	94	2	18204	48	FGFR2,GLI3
2.577e-02	-3.66	thyroid-other-neoplasm	COSMIC cancer mutations	thyroid-other-neoplasm	7637	29	16828	48	FGFR2,ATP1A2,PTPRZ1,MAML2,DAAM2,LRIG1,CLU,FOLH1,GLI3,LSAMP,TRPM3,MERTK,ZNRF3,GRAMD1C,GLIS3,LUZP2,ATP10B,PREX2,APC,ARHGEF26,PDLIM5,CTNND2,TTC28,ITPR2,PLEKHA7,ABLIM1,FNBP1,NFIA,TRPS1
2.580e-02	-3.66	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	2	7161	22	ITPR2,PLCB4
2.580e-02	-3.66	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	2	7161	22	ITPR2,PLCB4
2.581e-02	-3.66	SYNE1 (spectrin repeat containing nuclear envelope protein 1)	protein interactions	23345	97	2	19454	50	TNIK,APC
2.587e-02	-3.65	kinocilium	cellular component	GO:0060091	10	1	19108	50	CDC14A
2.587e-02	-3.65	9+2 non-motile cilium	cellular component	GO:0097732	10	1	19108	50	CDC14A
2.587e-02	-3.65	perineuronal net	cellular component	GO:0072534	10	1	19108	50	PTPRZ1
2.595e-02	-3.65	active transmembrane transporter activity	molecular function	GO:0022804	444	4	18094	46	SLC1A3,ATP13A4,ATP1A2,SLC1A2
2.600e-02	-3.65	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	4	18204	48	ATP1A2,SLC1A3,APOE,ATP13A4
2.602e-02	-3.65	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	48	PLCB4,ITPR2
2.606e-02	-3.65	spinal cord motor neuron cell fate specification	biological process	GO:0021520	10	1	18204	48	GLI3
2.606e-02	-3.65	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	48	APOE
2.606e-02	-3.65	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	48	APOE
2.606e-02	-3.65	vagina development	biological process	GO:0060068	10	1	18204	48	MERTK
2.606e-02	-3.65	endothelial cell morphogenesis	biological process	GO:0001886	10	1	18204	48	ARHGEF26
2.606e-02	-3.65	regulation of bone development	biological process	GO:1903010	10	1	18204	48	GLI3
2.606e-02	-3.65	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	48	APOE
2.606e-02	-3.65	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	48	APOE
2.606e-02	-3.65	action potential propagation	biological process	GO:0098870	10	1	18204	48	ATP1A2
2.606e-02	-3.65	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	48	APOE
2.606e-02	-3.65	prostate glandular acinus development	biological process	GO:0060525	10	1	18204	48	FGFR2
2.606e-02	-3.65	otolith development	biological process	GO:0048840	10	1	18204	48	LRIG1
2.606e-02	-3.65	neuronal action potential propagation	biological process	GO:0019227	10	1	18204	48	ATP1A2
2.606e-02	-3.65	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	48	APOE
2.609e-02	-3.65	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	3	ATP1A2
2.609e-02	-3.65	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	3	ATP1A2
2.609e-02	-3.65	RhoGEF	smart domains	SM00325	68	2	9717	36	ARHGEF26,PREX2
2.617e-02	-3.64	actin filament bundle	cellular component	GO:0032432	96	2	19108	50	ABLIM1,PDLIM5
2.617e-02	-3.64	sarcoplasm	cellular component	GO:0016528	96	2	19108	50	IRAG1,ITPR2
2.624e-02	-3.64	SYNE3 (spectrin repeat containing nuclear envelope family member 3)	protein interactions	161176	440	4	19454	50	ABLIM1,APC,PLEKHA7,GLI3
2.636e-02	-3.64	postsynapse	cellular component	GO:0098794	646	5	19108	50	TNIK,ATP1A2,PDLIM5,IGSF11,CTNND2
2.653e-02	-3.63	Diseases of signal transduction	REACTOME pathways	R-HSA-5663202	369	4	10285	32	FGFR2,QKI,MAML2,APC
2.653e-02	-3.63	hair cycle	biological process	GO:0042633	96	2	18204	48	FGFR2,LRIG1
2.653e-02	-3.63	molting cycle	biological process	GO:0042303	96	2	18204	48	LRIG1,FGFR2
2.659e-02	-3.63	response to wounding	biological process	GO:0009611	431	4	18204	48	NFIA,SLC1A3,MERTK,SLC1A2
2.661e-02	-3.63	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	41	TRPS1
2.661e-02	-3.63	HP	prosite domains	PS51089	8	1	12186	41	ABLIM1
2.661e-02	-3.63	DAD	prosite domains	PS51231	8	1	12186	41	DAAM2
2.664e-02	-3.63	amide binding	molecular function	GO:0033218	254	3	18094	46	CLU,APOE,FOLH1
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	ITPR2
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	ITPR2
2.673e-02	-3.62	protein tyrosine phosphatase activity	molecular function	GO:0004725	100	2	18094	46	CDC14A,PTPRZ1
2.673e-02	-3.62	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	46	SLC1A3,SLC1A2
2.680e-02	-3.62	LANCL1 (LanC like glutathione S-transferase 1)	protein interactions	10314	99	2	19454	50	FGFR2,MERTK
2.691e-02	-3.62	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	2	12186	41	APOE,GLIS3
2.698e-02	-3.61	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	48	ATP13A4,APOE,SLC1A3,ATP1A2
2.699e-02	-3.61	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	48	QKI,GLI3,PTPRZ1
2.704e-02	-3.61	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	48	SLC1A3,SLC1A2
2.711e-02	-3.61	metal ion binding	molecular function	GO:0046872	4239	17	18094	46	ZNRF3,ITPR2,ATP1A2,TRPS1,ATP13A4,RPE65,GLIS3,SLC1A3,APOE,GNA14,SLC1A2,ABLIM1,GLI3,ATP10B,FOLH1,PDLIM5,PLCB4
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	FGFR2,MERTK
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	ITPR2
2.731e-02	-3.60	MIDEAS (mitotic deacetylase associated SANT domain protein)	protein interactions	91748	100	2	19454	50	PDLIM5,NFIA
2.731e-02	-3.60	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	50	ABLIM1,ARHGEF26
2.731e-02	-3.60	SUFU (SUFU negative regulator of hedgehog signaling)	protein interactions	51684	100	2	19454	50	GLI3,GLIS3
2.735e-02	-3.60	TYRKINASE	prints domains	PR00109	98	2	5227	14	MERTK,FGFR2
2.756e-02	-3.59	positive regulation of cell division	biological process	GO:0051781	98	2	18204	48	FGFR2,CDC14A
2.758e-02	-3.59	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	22	PLCB4,ATP1A2
2.762e-02	-3.59	oligopeptide binding	molecular function	GO:1900750	11	1	18094	46	FOLH1
2.762e-02	-3.59	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	46	SLC1A2
2.762e-02	-3.59	cardiolipin binding	molecular function	GO:1901612	11	1	18094	46	RPE65
2.767e-02	-3.59	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	32	CLU
2.767e-02	-3.59	ion binding	molecular function	GO:0043167	6007	22	18094	46	ABLIM1,FOLH1,PLCB4,SLC1A3,TRPS1,TNIK,RPE65,GLIS3,ITPR2,ATP1A2,MERTK,ETNPPL,GLI3,ATP10B,PDLIM5,FGFR2,APOE,PITPNC1,SLC1A2,GNA14,ATP13A4,ZNRF3
2.778e-02	-3.58	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	4	18204	48	SLC1A3,ATP1A2,ATP13A4,APOE
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	IL7 (interleukin 7)	protein interactions	3574	11	1	19454	50	QKI
2.792e-02	-3.58	NOSTRIN (nitric oxide synthase trafficking)	protein interactions	115677	11	1	19454	50	APC
2.792e-02	-3.58	DAZ1 (deleted in azoospermia 1)	protein interactions	1617	11	1	19454	50	QKI
2.792e-02	-3.58	GAL3ST1 (galactose-3-O-sulfotransferase 1)	protein interactions	9514	11	1	19454	50	LRIG1
2.792e-02	-3.58	CACNA1D (calcium voltage-gated channel subunit alpha1 D)	protein interactions	776	11	1	19454	50	FGFR2
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.792e-02	-3.58	ATOSA (atos homolog A)	protein interactions	56204	11	1	19454	50	APC
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2)	protein interactions	10003	11	1	19454	50	FOLH1
2.792e-02	-3.58	C19orf18 (chromosome 19 open reading frame 18)	protein interactions	147685	11	1	19454	50	FGFR2
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	ITPR2
2.793e-02	-3.58	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	13	16828	48	APC,TRPM3,SLC1A3,MERTK,ITPR2,TRPS1,PTPRZ1,FGFR2,GRAMD1C,LRIG1,PREX2,GPC5,ATP10B
2.808e-02	-3.57	spinal cord development	biological process	GO:0021510	99	2	18204	48	GLI3,DAAM2
2.808e-02	-3.57	bone morphogenesis	biological process	GO:0060349	99	2	18204	48	FGFR2,GLI3
2.810e-02	-3.57	Protein tyrosine phosphatase superfamily	gene3d domains	3.90.190.10	88	2	14470	43	CDC14A,PTPRZ1
2.817e-02	-3.57	testis-germ_cell_tumour-teratoma	COSMIC cancer mutations	testis-germ_cell_tumour-teratoma	10	1	16828	48	FGFR2
2.817e-02	-3.57	central_nervous_system-supratentorial-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-supratentorial-primitive_neuroectodermal_tumour-medulloblastoma	10	1	16828	48	APC
2.817e-02	-3.57	large_intestine-left-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-left-carcinoma-adenocarcinoma	10	1	16828	48	APC
2.817e-02	-3.57	chiasm	COSMIC cancer mutations	chiasm	10	1	16828	48	QKI
2.817e-02	-3.57	large_intestine-right-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-right-carcinoma-adenocarcinoma	10	1	16828	48	APC
2.817e-02	-3.57	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	10	1	16828	48	APC
2.817e-02	-3.57	osteoblastic	COSMIC cancer mutations	osteoblastic	10	1	16828	48	APC
2.817e-02	-3.57	upper_aerodigestive_tract-sinonasal_and_nasal_cavity-carcinoma-adenocarcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-sinonasal_and_nasal_cavity-carcinoma-adenocarcinoma	10	1	16828	48	APC
2.817e-02	-3.57	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	48	PREX2
2.817e-02	-3.57	stomach-carcinoid-endocrine_tumour	COSMIC cancer mutations	stomach-carcinoid-endocrine_tumour	10	1	16828	48	APC
2.817e-02	-3.57	large_intestine-colon-carcinoid-endocrine_tumour	COSMIC cancer mutations	large_intestine-colon-carcinoid-endocrine_tumour	10	1	16828	48	APC
2.817e-02	-3.57	ovary-germ_cell_tumour-mixed	COSMIC cancer mutations	ovary-germ_cell_tumour-mixed	10	1	16828	48	APC
2.822e-02	-3.57	extrinsic component of plasma membrane	cellular component	GO:0019897	100	2	19108	50	GNA14,APC
2.824e-02	-3.57	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	3	ATP1A2
2.826e-02	-3.57	LIM	smart domains	SM00132	71	2	9717	36	PDLIM5,ABLIM1
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	MIR7-1 (microRNA 7-1)	protein interactions	407043	102	2	19454	50	QKI,MSI2
2.832e-02	-3.56	DOCK5 (dedicator of cytokinesis 5)	protein interactions	80005	102	2	19454	50	TTC28,ATP1A2
2.842e-02	-3.56	calcium ion transport	biological process	GO:0006816	251	3	18204	48	TRPM3,PLCB4,ITPR2
2.842e-02	-3.56	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	50	PTPRZ1
2.842e-02	-3.56	SFN (stratifin)	protein interactions	2810	671	5	19454	50	NFIA,PLEKHA7,APC,TNIK,ABLIM1
2.852e-02	-3.56	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	2	10285	32	ITPR2,PLCB4
2.861e-02	-3.55	response to alkaloid	biological process	GO:0043279	100	2	18204	48	SLC1A2,SLC1A3
2.863e-02	-3.55	intracellular mRNA localization	biological process	GO:0008298	11	1	18204	48	QKI
2.863e-02	-3.55	pyramidal neuron development	biological process	GO:0021860	11	1	18204	48	FGFR2
2.863e-02	-3.55	lactone metabolic process	biological process	GO:1901334	11	1	18204	48	ATP1A2
2.863e-02	-3.55	prostate gland growth	biological process	GO:0060736	11	1	18204	48	FGFR2
2.863e-02	-3.55	cell fate commitment involved in pattern specification	biological process	GO:0060581	11	1	18204	48	GLI3
2.863e-02	-3.55	physiological muscle hypertrophy	biological process	GO:0003298	11	1	18204	48	PDLIM5
2.863e-02	-3.55	cell growth involved in cardiac muscle cell development	biological process	GO:0061049	11	1	18204	48	PDLIM5
2.863e-02	-3.55	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	48	ATP1A2
2.863e-02	-3.55	epithelial cell differentiation involved in prostate gland development	biological process	GO:0060742	11	1	18204	48	FGFR2
2.863e-02	-3.55	physiological cardiac muscle hypertrophy	biological process	GO:0003301	11	1	18204	48	PDLIM5
2.863e-02	-3.55	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	48	APOE
2.863e-02	-3.55	polyamine transport	biological process	GO:0015846	11	1	18204	48	ATP13A4
2.863e-02	-3.55	branching involved in prostate gland morphogenesis	biological process	GO:0060442	11	1	18204	48	FGFR2
2.863e-02	-3.55	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	48	APOE
2.863e-02	-3.55	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	48	ATP1A2
2.863e-02	-3.55	regulation of fear response	biological process	GO:1903365	11	1	18204	48	APOE
2.863e-02	-3.55	thymocyte apoptotic process	biological process	GO:0070242	11	1	18204	48	GLI3
2.863e-02	-3.55	ventral spinal cord interneuron fate commitment	biological process	GO:0060579	11	1	18204	48	GLI3
2.891e-02	-3.54	ductal_carcinoma_in_situ	COSMIC cancer mutations	ductal_carcinoma_in_situ	93	2	16828	48	APC,FGFR2
2.891e-02	-3.54	carcinoma_in_situ	COSMIC cancer mutations	carcinoma_in_situ	93	2	16828	48	FGFR2,APC
2.891e-02	-3.54	breast-carcinoma_in_situ-ductal_carcinoma_in_situ	COSMIC cancer mutations	breast-carcinoma_in_situ-ductal_carcinoma_in_situ	93	2	16828	48	FGFR2,APC
2.893e-02	-3.54	response to endogenous stimulus	biological process	GO:0009719	1402	8	18204	48	ATP1A2,SLC1A2,SLC1A3,APC,FGFR2,GNA14,ITPR2,NFIA
2.896e-02	-3.54	thyroid	COSMIC cancer mutations	thyroid	9867	35	16828	48	MERTK,ZNRF3,FOLH1,CLU,TRPM3,GLI3,LSAMP,DAAM2,GPC5,TNIK,LRIG1,ATP1A2,FGFR2,PTPRZ1,MAML2,ITPR2,ABLIM1,PLEKHA7,FNBP1,TRPS1,NFIA,APC,PDLIM5,ARHGEF26,TTC28,CTNND2,LUZP2,ATP10B,PREX2,GRAMD1C,GULP1,SLC1A2,ATP13A4,GLIS3,PLCB4
2.922e-02	-3.53	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	13	16828	48	ATP1A2,FGFR2,PTPRZ1,SLC1A2,MAML2,LRIG1,APC,FOLH1,CTNND2,TRPM3,GLI3,RFX4,ZNRF3
2.927e-02	-3.53	VHP	smart domains	SM00153	8	1	9717	36	ABLIM1
2.928e-02	-3.53	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	18	16828	48	CDC14A,ATP1A2,SLC1A2,ATP13A4,RPE65,LRIG1,PREX2,SPAG16,GPC5,FOLH1,APC,GLI3,CTNND2,ABLIM1,ITPR2,RFX4,TRPS1,QKI
2.931e-02	-3.53	GBD/FH3_dom	interpro domains	IPR014768	11	1	18521	50	DAAM2
2.931e-02	-3.53	Peptidase_M28	interpro domains	IPR007484	11	1	18521	50	FOLH1
2.936e-02	-3.53	AGFG1 (ArfGAP with FG repeats 1)	protein interactions	3267	104	2	19454	50	FGFR2,APC
2.940e-02	-3.53	GSK3A (glycogen synthase kinase 3 alpha)	protein interactions	2931	456	4	19454	50	GLI3,APC,TTC28,TNIK
2.941e-02	-3.53	Gap junction	KEGG pathways	ko04540	88	2	7161	22	PLCB4,ITPR2
2.941e-02	-3.53	Gap junction	KEGG pathways	hsa04540	88	2	7161	22	ITPR2,PLCB4
2.946e-02	-3.52	LGR4 (leucine rich repeat containing G protein-coupled receptor 4)	protein interactions	55366	261	3	19454	50	ZNRF3,DAAM2,ATP1A2
2.952e-02	-3.52	anchoring junction	cellular component	GO:0070161	902	6	19108	50	APC,PDLIM5,CTNND2,IGSF11,PLEKHA7,ATP1A2
2.967e-02	-3.52	artery development	biological process	GO:0060840	102	2	18204	48	APOE,GLI3
2.988e-02	-3.51	BEND3 (BEN domain containing 3)	protein interactions	57673	105	2	19454	50	TRPS1,TNIK
2.988e-02	-3.51	Peptidase_M28	pfam domains	PF04389	11	1	17795	49	FOLH1
2.988e-02	-3.51	LRRCT	pfam domains	PF01463	11	1	17795	49	LRIG1
2.989e-02	-3.51	RFX_DBD	prosite domains	PS51526	9	1	12186	41	RFX4
2.994e-02	-3.51	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	16	16828	48	GLI3,TRPM3,CTNND2,TTC28,FOLH1,APC,LRIG1,PREX2,GPC5,DAAM2,IGSF11,PLCB4,NPAS3,PTPRZ1,GRAMD1C,ATP1A2
3.009e-02	-3.50	gamma-catenin binding	molecular function	GO:0045295	12	1	18094	46	APC
3.009e-02	-3.50	inositol 1,4,5 trisphosphate binding	molecular function	GO:0070679	12	1	18094	46	ITPR2
3.021e-02	-3.50	vitamin metabolic process	biological process	GO:0006766	103	2	18204	48	RPE65,ATP1A2
3.021e-02	-3.50	regulation of neural precursor cell proliferation	biological process	GO:2000177	103	2	18204	48	PTPRZ1,GLI3
3.026e-02	-3.50	Pathways in cancer	KEGG pathways	hsa05200	395	4	7161	22	FGFR2,GLI3,PLCB4,APC
3.028e-02	-3.50	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	48	PDLIM5,DAAM2,TNIK,APC,APOE
3.028e-02	-3.50	steroid binding	molecular function	GO:0005496	107	2	18094	46	GRAMD1C,ATP1A2
3.040e-02	-3.49	USP30 (ubiquitin specific peptidase 30)	protein interactions	84749	106	2	19454	50	APC,QKI
3.042e-02	-3.49	SOWAHB (sosondowah ankyrin repeat domain family member B)	protein interactions	345079	12	1	19454	50	PLEKHA7
3.042e-02	-3.49	SNX22 (sorting nexin 22)	protein interactions	79856	12	1	19454	50	FGFR2
3.042e-02	-3.49	IL15 (interleukin 15)	protein interactions	3600	12	1	19454	50	LRIG1
3.042e-02	-3.49	C8orf74 (chromosome 8 open reading frame 74)	protein interactions	203076	12	1	19454	50	FGFR2
3.042e-02	-3.49	SSTR2 (somatostatin receptor 2)	protein interactions	6752	12	1	19454	50	GNA14
3.042e-02	-3.49	PDE6G (phosphodiesterase 6G)	protein interactions	5148	12	1	19454	50	FNBP1
3.042e-02	-3.49	LGR5 (leucine rich repeat containing G protein-coupled receptor 5)	protein interactions	8549	12	1	19454	50	ZNRF3
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.044e-02	-3.49	Prot-tyrosine_phosphatase-like	interpro domains	IPR029021	101	2	18521	50	CDC14A,PTPRZ1
3.058e-02	-3.49	CTNNB1 (catenin beta 1)	protein interactions	1499	926	6	19454	50	PLEKHA7,APOE,APC,CTNND2,PDLIM5,PTPRZ1
3.069e-02	-3.48	Acetylcholine regulates insulin secretion	REACTOME pathways	R-HSA-399997	10	1	10285	32	GNA14
3.069e-02	-3.48	FGFR2b ligand binding and activation	REACTOME pathways	R-HSA-190377	10	1	10285	32	FGFR2
3.094e-02	-3.48	metaplastic_carcinoma	COSMIC cancer mutations	metaplastic_carcinoma	11	1	16828	48	APC
3.094e-02	-3.48	kidney-other-oncocytoma	COSMIC cancer mutations	kidney-other-oncocytoma	11	1	16828	48	APC
3.094e-02	-3.48	oncocytoma	COSMIC cancer mutations	oncocytoma	11	1	16828	48	APC
3.094e-02	-3.48	gastrointestinal_tract_(site_indeterminate)-carcinoid-endocrine_tumour	COSMIC cancer mutations	gastrointestinal_tract_(site_indeterminate)-carcinoid-endocrine_tumour	11	1	16828	48	APC
3.094e-02	-3.48	breast-carcinoma-metaplastic_carcinoma	COSMIC cancer mutations	breast-carcinoma-metaplastic_carcinoma	11	1	16828	48	APC
3.094e-02	-3.48	adrenal_gland-adrenal_gland-adrenal_cortical_hyperplasia	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_hyperplasia	11	1	16828	48	APC
3.094e-02	-3.48	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	48	PREX2
3.094e-02	-3.48	skin-foot-malignant_melanoma-nodular	COSMIC cancer mutations	skin-foot-malignant_melanoma-nodular	11	1	16828	48	APC
3.094e-02	-3.48	small_intestine-ileum-carcinoid-endocrine_tumour	COSMIC cancer mutations	small_intestine-ileum-carcinoid-endocrine_tumour	11	1	16828	48	APC
3.094e-02	-3.48	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	48	PREX2
3.094e-02	-3.48	seborrhoeic_keratosis	COSMIC cancer mutations	seborrhoeic_keratosis	11	1	16828	48	APC
3.096e-02	-3.48	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	50	ATP1A2
3.096e-02	-3.48	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	50	PTPRZ1
3.096e-02	-3.48	beta-catenin destruction complex	cellular component	GO:0030877	12	1	19108	50	APC
3.096e-02	-3.48	endoplasmic reticulum-plasma membrane contact site	cellular component	GO:0140268	12	1	19108	50	GRAMD1C
3.120e-02	-3.47	negative thymic T cell selection	biological process	GO:0045060	12	1	18204	48	GLI3
3.120e-02	-3.47	endothelin receptor signaling pathway	biological process	GO:0086100	12	1	18204	48	PLCB4
3.120e-02	-3.47	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	48	SLC1A2
3.120e-02	-3.47	regulation of protein localization to centrosome	biological process	GO:1904779	12	1	18204	48	APC
3.120e-02	-3.47	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	48	APOE
3.120e-02	-3.47	auditory behavior	biological process	GO:0031223	12	1	18204	48	SLC1A3
3.120e-02	-3.47	microglia differentiation	biological process	GO:0014004	12	1	18204	48	QKI
3.129e-02	-3.46	cellular response to alcohol	biological process	GO:0097306	105	2	18204	48	GRAMD1C,ITPR2
3.129e-02	-3.46	inner ear morphogenesis	biological process	GO:0042472	105	2	18204	48	FGFR2,LRIG1
3.129e-02	-3.46	regulation of postsynapse organization	biological process	GO:0099175	105	2	18204	48	PDLIM5,APOE
3.129e-02	-3.46	gland morphogenesis	biological process	GO:0022612	105	2	18204	48	GLI3,FGFR2
3.137e-02	-3.46	Leucine-rich Repeat Variant	gene3d domains	1.25.10.10	232	3	14470	43	DAAM2,CTNND2,APC
3.147e-02	-3.46	EN1 (engrailed homeobox 1)	protein interactions	2019	108	2	19454	50	TRPS1,NFIA
3.147e-02	-3.46	PAX8 (paired box 8)	protein interactions	7849	108	2	19454	50	NFIA,TRPS1
3.170e-02	-3.45	response to alcohol	biological process	GO:0097305	262	3	18204	48	FGFR2,ITPR2,GRAMD1C
3.173e-02	-3.45	phosphatase activity	molecular function	GO:0016791	272	3	18094	46	ATP1A2,CDC14A,PTPRZ1
3.177e-02	-3.45	Tgif disruption of Shh signaling	WikiPathways	WP3674	9	1	5310	19	GLI3
3.179e-02	-3.45	regulation of nervous system development	biological process	GO:0051960	456	4	18204	48	GLI3,QKI,DAAM2,PTPRZ1
3.179e-02	-3.45	pattern specification process	biological process	GO:0007389	456	4	18204	48	APC,GLI3,FGFR2,DAAM2
3.184e-02	-3.45	pigmentation	biological process	GO:0043473	106	2	18204	48	APOE,GLI3
3.184e-02	-3.45	organ growth	biological process	GO:0035265	106	2	18204	48	FGFR2,PDLIM5
3.192e-02	-3.44	GnRH signaling pathway	KEGG pathways	hsa04912	92	2	7161	22	PLCB4,ITPR2
3.192e-02	-3.44	GnRH signaling pathway	KEGG pathways	ko04912	92	2	7161	22	ITPR2,PLCB4
3.193e-02	-3.44	PLC_EF-hand-like	interpro domains	IPR015359	12	1	18521	50	PLCB4
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.200e-02	-3.44	MIR34B (microRNA 34b)	protein interactions	407041	109	2	19454	50	MSI2,QKI
3.213e-02	-3.44	FBXW11 (F-box and WD repeat domain containing 11)	protein interactions	23291	469	4	19454	50	GLI3,QKI,APC,MERTK
3.222e-02	-3.44	response to organonitrogen compound	biological process	GO:0010243	915	6	18204	48	ITPR2,GNA14,APC,SLC1A3,SLC1A2,TNIK
3.234e-02	-3.43	Platelet homeostasis	REACTOME pathways	R-HSA-418346	91	2	10285	32	IRAG1,ITPR2
3.236e-02	-3.43	TYR_PHOSPHATASE_2	prosite domains	PS50056	84	2	12186	41	PTPRZ1,CDC14A
3.256e-02	-3.42	EF-hand_like	pfam domains	PF09279	12	1	17795	49	PLCB4
3.256e-02	-3.42	MH1	pfam domains	PF03165	12	1	17795	49	NFIA
3.256e-02	-3.42	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	48	DAAM2,APC,GLI3,FGFR2,CTNND2,ZNRF3,NFIA,MERTK,MAML2,TNIK
3.256e-02	-3.42	glycerophospholipid flippase activity	molecular function	GO:0140333	13	1	18094	46	ATP10B
3.256e-02	-3.42	potassium ion binding	molecular function	GO:0030955	13	1	18094	46	ATP1A2
3.272e-02	-3.42	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	48	PTPRZ1,APC,FGFR2,LRIG1,TNIK,MERTK
3.272e-02	-3.42	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	48	MERTK,LRIG1,TNIK,PTPRZ1,FGFR2,APC
3.287e-02	-3.42	Drf_FH3	smart domains	SM01139	9	1	9717	36	DAAM2
3.287e-02	-3.42	Drf_GBD	smart domains	SM01140	9	1	9717	36	DAAM2
3.291e-02	-3.41	PLPPR4 (phospholipid phosphatase related 4)	protein interactions	9890	13	1	19454	50	ZNRF3
3.291e-02	-3.41	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	50	APOE
3.291e-02	-3.41	FGF10 (fibroblast growth factor 10)	protein interactions	2255	13	1	19454	50	FGFR2
3.291e-02	-3.41	Rbm47 (RNA binding motif protein 47)	protein interactions	245945	13	1	19454	50	QKI
3.291e-02	-3.41	Pias1 (protein inhibitor of activated STAT 1)	protein interactions	56469	13	1	19454	50	GLI3
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.298e-02	-3.41	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	42	16828	48	LUZP2,ATP10B,PREX2,GULP1,GRAMD1C,CDC14A,SLC1A2,GLIS3,ATP13A4,MSI2,PLCB4,ITPR2,PLEKHA7,ABLIM1,TRPS1,GNA14,APC,ARHGEF26,PDLIM5,CTNND2,TTC28,APOE,IGSF11,NKAIN3,RPE65,TNIK,GPC5,DAAM2,SPAG16,LRIG1,FGFR2,ATP1A2,MAML2,MERTK,QKI,RFX4,CLU,FOLH1,GLI3,LSAMP,SLC1A3,TRPM3
3.309e-02	-3.41	DLG3 (discs large MAGUK scaffold protein 3)	protein interactions	1741	111	2	19454	50	ARHGEF26,APC
3.315e-02	-3.41	MIR	prosite domains	PS50919	10	1	12186	41	ITPR2
3.321e-02	-3.40	Amoebiasis	KEGG pathways	hsa05146	94	2	7161	22	GNA14,PLCB4
3.321e-02	-3.40	Amoebiasis	KEGG pathways	ko05146	94	2	7161	22	GNA14,PLCB4
3.325e-02	-3.40	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	48	APOE,APC,TNIK,DAAM2,PDLIM5
3.330e-02	-3.40	Hedgehog signaling	KEGG pathways	M00678	11	1	7161	22	GLI3
3.330e-02	-3.40	Hedgehog signaling	KEGG pathways	hsa_M00678	11	1	7161	22	GLI3
3.350e-02	-3.40	chylomicron	cellular component	GO:0042627	13	1	19108	50	APOE
3.350e-02	-3.40	Wnt signalosome	cellular component	GO:1990909	13	1	19108	50	APC
3.351e-02	-3.40	postsynapse organization	biological process	GO:0099173	109	2	18204	48	APOE,CTNND2
3.363e-02	-3.39	cation binding	molecular function	GO:0043169	4341	17	18094	46	ZNRF3,ITPR2,ATP1A2,TRPS1,ATP13A4,RPE65,GLIS3,SLC1A3,APOE,GNA14,SLC1A2,ABLIM1,GLI3,ATP10B,FOLH1,PDLIM5,PLCB4
3.363e-02	-3.39	TSC22D4 (TSC22 domain family member 4)	protein interactions	81628	112	2	19454	50	CLU,ABLIM1
3.363e-02	-3.39	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	2	19454	50	TRPS1,NFIA
3.371e-02	-3.39	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma	12	1	16828	48	APC
3.371e-02	-3.39	soft_tissue-fibrous_tissue_and_uncertain_origin-desmoid_tumour-fibromatosis	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-desmoid_tumour-fibromatosis	12	1	16828	48	APC
3.371e-02	-3.39	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-classic	12	1	16828	48	APC
3.371e-02	-3.39	left	COSMIC cancer mutations	left	12	1	16828	48	APC
3.371e-02	-3.39	pituitary-adenoma-GH-PRL	COSMIC cancer mutations	pituitary-adenoma-GH-PRL	12	1	16828	48	APC
3.371e-02	-3.39	desmoid_tumour-fibromatosis	COSMIC cancer mutations	desmoid_tumour-fibromatosis	12	1	16828	48	APC
3.371e-02	-3.39	FSH-LH	COSMIC cancer mutations	FSH-LH	12	1	16828	48	APC
3.371e-02	-3.39	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	12	1	16828	48	QKI
3.371e-02	-3.39	pituitary-adenoma-FSH-LH	COSMIC cancer mutations	pituitary-adenoma-FSH-LH	12	1	16828	48	APC
3.371e-02	-3.39	GH-PRL	COSMIC cancer mutations	GH-PRL	12	1	16828	48	APC
3.375e-02	-3.39	ventral spinal cord interneuron differentiation	biological process	GO:0021514	13	1	18204	48	GLI3
3.375e-02	-3.39	negative T cell selection	biological process	GO:0043383	13	1	18204	48	GLI3
3.375e-02	-3.39	regulation of pseudopodium assembly	biological process	GO:0031272	13	1	18204	48	APC
3.375e-02	-3.39	branching involved in labyrinthine layer morphogenesis	biological process	GO:0060670	13	1	18204	48	FGFR2
3.375e-02	-3.39	phospholipid efflux	biological process	GO:0033700	13	1	18204	48	APOE
3.375e-02	-3.39	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	48	APOE
3.375e-02	-3.39	glial cell fate commitment	biological process	GO:0021781	13	1	18204	48	NFIA
3.375e-02	-3.39	ruffle assembly	biological process	GO:0097178	13	1	18204	48	ARHGEF26
3.375e-02	-3.39	positive regulation of pseudopodium assembly	biological process	GO:0031274	13	1	18204	48	APC
3.375e-02	-3.39	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	48	ATP1A2
3.375e-02	-3.39	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	48	ATP1A2
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.398e-02	-3.38	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	3	16828	48	GLIS3,PTPRZ1,APC
3.408e-02	-3.38	phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	GO:0007200	110	2	18204	48	GNA14,PLCB4
3.410e-02	-3.38	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	5	18094	46	SLC1A3,TRPM3,ITPR2,ATP1A2,SLC1A2
3.415e-02	-3.38	hemopoiesis	biological process	GO:0030097	688	5	18204	48	PTPRZ1,MERTK,GLI3,FGFR2,QKI
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	PDLIM5,ZNRF3
3.425e-02	-3.37	RBFOX2 (RNA binding fox-1 homolog 2)	protein interactions	23543	277	3	19454	50	QKI,APC,MSI2
3.437e-02	-3.37	regulation of signaling	biological process	GO:0023051	3534	15	18204	48	ATP1A2,SLC1A3,FGFR2,CLU,MERTK,IGSF11,PREX2,DAAM2,CTNND2,GLI3,APC,ZNRF3,GPC5,APOE,TNIK
3.447e-02	-3.37	SH3_1	pfam domains	PF00018	106	2	17795	49	ARHGEF26,FNBP1
3.454e-02	-3.37	HR1_rho-bd	interpro domains	IPR011072	13	1	18521	50	FNBP1
3.492e-02	-3.35	regulation of cell communication	biological process	GO:0010646	3541	15	18204	48	ATP1A2,SLC1A3,DAAM2,PREX2,ZNRF3,CTNND2,GLI3,FGFR2,APC,CLU,MERTK,IGSF11,GPC5,TNIK,APOE
3.497e-02	-3.35	circulatory system development	biological process	GO:0072359	933	6	18204	48	APOE,QKI,PDLIM5,FGFR2,GLI3,APC
3.500e-02	-3.35	PH_domain	interpro domains	IPR001849	266	3	18521	50	ARHGEF26,PREX2,PLEKHA7
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	TRPM3,ITPR2
3.518e-02	-3.35	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	2	7161	22	ITPR2,PLCB4
3.518e-02	-3.35	Phosphatidylinositol signaling system	KEGG pathways	hsa04070	97	2	7161	22	PLCB4,ITPR2
3.518e-02	-3.35	Phosphatidylinositol signaling system	KEGG pathways	ko04070	97	2	7161	22	ITPR2,PLCB4
3.518e-02	-3.35	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	2	7161	22	PLCB4,ITPR2
3.520e-02	-3.35	membrane	cellular component	GO:0016020	9220	31	19108	50	PDLIM5,IGSF11,GNA14,ATP1A2,IRAG1,RPE65,NKAIN3,APOE,FOLH1,ATP10B,PTPRZ1,PREX2,TRPM3,MERTK,ZNRF3,SLC1A3,ATP13A4,CTNND2,TNIK,PLEKHA7,ITPR2,SLC1A2,FGFR2,PLCB4,APC,FNBP1,GRAMD1C,CLU,LSAMP,LRIG1,GPC5
3.520e-02	-3.35	TyrKc	smart domains	SM00219	80	2	9717	36	FGFR2,MERTK
3.521e-02	-3.35	phospholipid binding	molecular function	GO:0005543	489	4	18094	46	PITPNC1,ITPR2,APOE,RPE65
3.524e-02	-3.35	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	19	APOE
3.530e-02	-3.34	PLEKHA7 (pleckstrin homology domain containing A7)	protein interactions	144100	115	2	19454	50	CDC14A,PLEKHA7
3.530e-02	-3.34	TBXT (T-box transcription factor T)	protein interactions	6862	115	2	19454	50	NFIA,TRPS1
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	ZNRF3
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	50	APOE
3.540e-02	-3.34	FGF7 (fibroblast growth factor 7)	protein interactions	2252	14	1	19454	50	FGFR2
3.540e-02	-3.34	PLXNA4 (plexin A4)	protein interactions	91584	14	1	19454	50	CLU
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.540e-02	-3.34	MB (myoglobin)	protein interactions	4151	14	1	19454	50	MAML2
3.567e-02	-3.33	calcium channel activity	molecular function	GO:0005262	117	2	18094	46	ITPR2,TRPM3
3.567e-02	-3.33	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	2	18094	46	SLC1A2,SLC1A3
3.572e-02	-3.33	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	6	16828	48	APC,FGFR2,TNIK,PREX2,TRPS1,MERTK
3.572e-02	-3.33	skin-sole-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-sole-malignant_melanoma-acral_lentiginous	254	3	16828	48	LUZP2,APC,PLCB4
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.579e-02	-3.33	dendrite development	biological process	GO:0016358	113	2	18204	48	PREX2,CTNND2
3.585e-02	-3.33	Estrogen signaling pathway	KEGG pathways	ko04915	98	2	7161	22	ITPR2,PLCB4
3.585e-02	-3.33	Estrogen signaling pathway	KEGG pathways	hsa04915	98	2	7161	22	ITPR2,PLCB4
3.586e-02	-3.33	FCGRT (Fc gamma receptor and transporter)	protein interactions	2217	116	2	19454	50	FGFR2,CLU
3.603e-02	-3.32	chromaffin granule	cellular component	GO:0042583	14	1	19108	50	CLU
3.603e-02	-3.32	phospholipid-translocating ATPase complex	cellular component	GO:1990531	14	1	19108	50	ATP10B
3.611e-02	-3.32	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	2	16828	48	GPC5,QKI
3.615e-02	-3.32	sensory organ morphogenesis	biological process	GO:0090596	276	3	18204	48	LRIG1,FGFR2,GLI3
3.615e-02	-3.32	learning or memory	biological process	GO:0007611	276	3	18204	48	ATP1A2,PTPRZ1,APOE
3.615e-02	-3.32	RCOR1 (REST corepressor 1)	protein interactions	23186	487	4	19454	50	TRPS1,TTC28,APC,FNBP1
3.627e-02	-3.32	Ion_trans	pfam domains	PF00520	109	2	17795	49	ITPR2,TRPM3
3.630e-02	-3.32	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	48	SLC1A2
3.630e-02	-3.32	sodium ion export across plasma membrane	biological process	GO:0036376	14	1	18204	48	ATP1A2
3.630e-02	-3.32	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	48	APOE
3.630e-02	-3.32	layer formation in cerebral cortex	biological process	GO:0021819	14	1	18204	48	GLI3
3.630e-02	-3.32	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	48	ATP1A2
3.630e-02	-3.32	mechanosensory behavior	biological process	GO:0007638	14	1	18204	48	SLC1A3
3.630e-02	-3.32	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	48	SPAG16
3.630e-02	-3.32	otic vesicle development	biological process	GO:0071599	14	1	18204	48	FGFR2
3.630e-02	-3.32	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	48	ATP1A2
3.630e-02	-3.32	cellular response to ethanol	biological process	GO:0071361	14	1	18204	48	ITPR2
3.630e-02	-3.32	radial glial cell differentiation	biological process	GO:0060019	14	1	18204	48	GLI3
3.630e-02	-3.32	terpenoid biosynthetic process	biological process	GO:0016114	14	1	18204	48	RPE65
3.630e-02	-3.32	negative regulation of oligodendrocyte differentiation	biological process	GO:0048715	14	1	18204	48	DAAM2
3.630e-02	-3.32	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	48	APOE
3.641e-02	-3.31	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	41	TRPS1
3.641e-02	-3.31	GBD_FH3	prosite domains	PS51232	11	1	12186	41	DAAM2
3.642e-02	-3.31	ELK3 (ETS transcription factor ELK3)	protein interactions	2004	117	2	19454	50	NFIA,TRPS1
3.645e-02	-3.31	MIR	smart domains	SM00472	10	1	9717	36	ITPR2
3.647e-02	-3.31	skin-head_neck-carcinoma-Merkel_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-Merkel_cell_carcinoma	13	1	16828	48	APC
3.647e-02	-3.31	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	48	PREX2
3.647e-02	-3.31	stomach-adenoma	COSMIC cancer mutations	stomach-adenoma	13	1	16828	48	APC
3.647e-02	-3.31	skin-lower_extremity-carcinoma-Merkel_cell_carcinoma	COSMIC cancer mutations	skin-lower_extremity-carcinoma-Merkel_cell_carcinoma	13	1	16828	48	APC
3.647e-02	-3.31	skin-upper_extremity-carcinoma-Merkel_cell_carcinoma	COSMIC cancer mutations	skin-upper_extremity-carcinoma-Merkel_cell_carcinoma	13	1	16828	48	APC
3.647e-02	-3.31	skin-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-malignant_melanoma-lentigo_maligna	13	1	16828	48	FGFR2
3.647e-02	-3.31	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	13	1	16828	48	QKI
3.656e-02	-3.31	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	5	16828	48	PREX2,TRPS1,TNIK,MERTK,FGFR2
3.661e-02	-3.31	SNX27 (sorting nexin 27)	protein interactions	81609	489	4	19454	50	CLU,FNBP1,ABLIM1,SLC1A3
3.672e-02	-3.30	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	32	GPC5
3.672e-02	-3.30	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	32	GPC5
3.675e-02	-3.30	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	7	16828	48	FGFR2,APC,GLI3,PLCB4,CTNND2,ATP13A4,PREX2
3.699e-02	-3.30	CEACAM8 (CEA cell adhesion molecule 8)	protein interactions	1088	118	2	19454	50	APOE,CLU
3.699e-02	-3.30	MAPRE2 (microtubule associated protein RP/EB family member 2)	protein interactions	10982	118	2	19454	50	APC,CDC14A
3.704e-02	-3.30	blood microparticle	cellular component	GO:0072562	116	2	19108	50	APOE,CLU
3.715e-02	-3.29	P-type_ATPase_N	interpro domains	IPR032631	14	1	18521	50	ATP10B
3.715e-02	-3.29	P-type_ATPase_IV	interpro domains	IPR006539	14	1	18521	50	ATP10B
3.715e-02	-3.29	P_typ_ATPase_c	interpro domains	IPR032630	14	1	18521	50	ATP10B
3.715e-02	-3.29	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	48	ATP13A4,APC,PTPRZ1
3.748e-02	-3.28	muscle alpha-actinin binding	molecular function	GO:0051371	15	1	18094	46	PDLIM5
3.756e-02	-3.28	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	50	APOE,CLU
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.777e-02	-3.28	DDX27 (DEAD-box helicase 27)	protein interactions	55661	288	3	19454	50	MERTK,FGFR2,CDC14A
3.779e-02	-3.28	NEDD4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	4734	494	4	19454	50	FGFR2,TNIK,GLIS3,MAML2
3.788e-02	-3.27	KHDC1 (KH domain containing 1)	protein interactions	80759	15	1	19454	50	TTC28
3.788e-02	-3.27	ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1)	protein interactions	953	15	1	19454	50	APC
3.788e-02	-3.27	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	50	TNIK
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CLU
3.788e-02	-3.27	FGF9 (fibroblast growth factor 9)	protein interactions	2254	15	1	19454	50	FGFR2
3.788e-02	-3.27	TESPA1 (thymocyte expressed, positive selection associated 1)	protein interactions	9840	15	1	19454	50	ITPR2
3.788e-02	-3.27	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	2	7161	22	PLCB4,ITPR2
3.788e-02	-3.27	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	2	7161	22	ITPR2,PLCB4
3.788e-02	-3.27	GATA	pfam domains	PF00320	14	1	17795	49	TRPS1
3.788e-02	-3.27	PhoLip_ATPase_N	pfam domains	PF16209	14	1	17795	49	ATP10B
3.788e-02	-3.27	PhoLip_ATPase_C	pfam domains	PF16212	14	1	17795	49	ATP10B
3.800e-02	-3.27	upper_leg	COSMIC cancer mutations	upper_leg	880	6	16828	48	NFIA,PREX2,LRIG1,FGFR2,PLCB4,GLIS3
3.802e-02	-3.27	OCLN (occludin)	protein interactions	100506658	495	4	19454	50	APC,PLEKHA7,TNIK,ABLIM1
3.809e-02	-3.27	cytoskeletal protein binding	molecular function	GO:0008092	989	6	18094	46	APOE,CLU,PDLIM5,DAAM2,APC,ABLIM1
3.810e-02	-3.27	YTHDF1 (YTH N6-methyladenosine RNA binding protein F1)	protein interactions	54915	289	3	19454	50	MERTK,QKI,GLI3
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	APC,ABLIM1,PDLIM5
3.811e-02	-3.27	ribonucleoside triphosphate phosphatase activity	molecular function	GO:0017111	736	5	18094	46	CLU,ATP1A2,GNA14,ATP13A4,ATP10B
3.855e-02	-3.26	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	50	APOE
3.855e-02	-3.26	axolemma	cellular component	GO:0030673	15	1	19108	50	SLC1A2
3.857e-02	-3.26	Chagas disease (American trypanosomiasis)	KEGG pathways	ko05142	102	2	7161	22	PLCB4,GNA14
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	ko04922	102	2	7161	22	PLCB4,ITPR2
3.857e-02	-3.26	Chagas disease (American trypanosomiasis)	KEGG pathways	hsa05142	102	2	7161	22	PLCB4,GNA14
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	hsa04922	102	2	7161	22	PLCB4,ITPR2
3.865e-02	-3.25	lung-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	lung-carcinoma-mixed_adenosquamous_carcinoma	109	2	16828	48	APC,FGFR2
3.870e-02	-3.25	neuronal cell body	cellular component	GO:0043025	489	4	19108	50	APOE,CTNND2,SLC1A3,ATP1A2
3.872e-02	-3.25	MED15 (mediator complex subunit 15)	protein interactions	51586	121	2	19454	50	NFIA,QKI
3.884e-02	-3.25	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	47	16828	48	NFIA,PDLIM5,APC,GNA14,LUZP2,PREX2,MSI2,ATP13A4,GLIS3,CLU,LSAMP,SLC1A3,IGSF11,LRIG1,TNIK,PTPRZ1,FGFR2,MAML2,PLEKHA7,ABLIM1,ITPR2,TRPS1,ARHGEF26,APOE,CTNND2,TTC28,ATP10B,CDC14A,GULP1,GRAMD1C,PLCB4,SLC1A2,MERTK,ZNRF3,RFX4,QKI,FOLH1,GLI3,TRPM3,PITPNC1,NKAIN3,RPE65,SPAG16,DAAM2,GPC5,ATP1A2,NPAS3
3.884e-02	-3.25	synapse maturation	biological process	GO:0060074	15	1	18204	48	NFIA
3.884e-02	-3.25	protein homotrimerization	biological process	GO:0070207	15	1	18204	48	SLC1A2
3.884e-02	-3.25	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	48	APOE
3.884e-02	-3.25	lysosomal membrane organization	biological process	GO:0097212	15	1	18204	48	ATP10B
3.884e-02	-3.25	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	48	ATP1A2
3.884e-02	-3.25	neuroblast division	biological process	GO:0055057	15	1	18204	48	FGFR2
3.884e-02	-3.25	regulation of phospholipid transport	biological process	GO:2001138	15	1	18204	48	APOE
3.884e-02	-3.25	exit from mitosis	biological process	GO:0010458	15	1	18204	48	NFIA
3.884e-02	-3.25	dorsal/ventral neural tube patterning	biological process	GO:0021904	15	1	18204	48	GLI3
3.884e-02	-3.25	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	48	ATP1A2
3.884e-02	-3.25	pyramidal neuron differentiation	biological process	GO:0021859	15	1	18204	48	FGFR2
3.884e-02	-3.25	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	48	APOE
3.898e-02	-3.24	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	3	16828	48	PREX2,SLC1A2,APC
3.922e-02	-3.24	adrenal_cortical_hyperplasia	COSMIC cancer mutations	adrenal_cortical_hyperplasia	14	1	16828	48	APC
3.922e-02	-3.24	chondroid	COSMIC cancer mutations	chondroid	14	1	16828	48	APC
3.922e-02	-3.24	fallopian_tube-carcinoma-carcinosarcoma-malignant_mesodermal_mixed_tumour	COSMIC cancer mutations	fallopian_tube-carcinoma-carcinosarcoma-malignant_mesodermal_mixed_tumour	14	1	16828	48	APC
3.922e-02	-3.24	large_intestine-rectum-adenoma-tubulovillous	COSMIC cancer mutations	large_intestine-rectum-adenoma-tubulovillous	14	1	16828	48	APC
3.922e-02	-3.24	large_intestine-rectum-adenoma-tubular	COSMIC cancer mutations	large_intestine-rectum-adenoma-tubular	14	1	16828	48	APC
3.922e-02	-3.24	vagina-carcinoma-carcinosarcoma-malignant_mesodermal_mixed_tumour	COSMIC cancer mutations	vagina-carcinoma-carcinosarcoma-malignant_mesodermal_mixed_tumour	14	1	16828	48	APC
3.922e-02	-3.24	bone-vertebrae-chordoma-chondroid	COSMIC cancer mutations	bone-vertebrae-chordoma-chondroid	14	1	16828	48	APC
3.930e-02	-3.24	mixed_adenosquamous_carcinoma	COSMIC cancer mutations	mixed_adenosquamous_carcinoma	110	2	16828	48	APC,FGFR2
3.931e-02	-3.24	inorganic ion transmembrane transport	biological process	GO:0098660	715	5	18204	48	TRPM3,ATP1A2,SLC1A3,PLCB4,ITPR2
3.941e-02	-3.23	cellular response to stimulus	biological process	GO:0051716	6307	23	18204	48	ITPR2,FGFR2,GRAMD1C,SLC1A2,SLC1A3,ATP1A2,IRAG1,MAML2,FNBP1,MERTK,CLU,NFIA,GNA14,ZNRF3,APC,CTNND2,GLI3,DAAM2,PREX2,PITPNC1,TNIK,APOE,PLCB4
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.948e-02	-3.23	PHPHLIPASEC	prints domains	PR00390	15	1	5227	14	PLCB4
3.972e-02	-3.23	FGFR2c ligand binding and activation	REACTOME pathways	R-HSA-190375	13	1	10285	32	FGFR2
3.972e-02	-3.23	Notch-HLH transcription pathway	REACTOME pathways	R-HSA-350054	13	1	10285	32	MAML2
3.972e-02	-3.23	NOTCH2 intracellular domain regulates transcription	REACTOME pathways	R-HSA-2197563	13	1	10285	32	MAML2
3.972e-02	-3.23	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	32	ITPR2
3.973e-02	-3.23	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-angioimmunoblastic_T_cell_lymphoma	265	3	16828	48	ITPR2,APC,TTC28
3.974e-02	-3.23	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	41	MERTK,FGFR2
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	DAAM2
3.975e-02	-3.23	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	1	18521	50	PLCB4
3.975e-02	-3.23	PI-PLC_fam	interpro domains	IPR001192	15	1	18521	50	PLCB4
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	DAAM2
3.977e-02	-3.22	KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)	protein interactions	10008	294	3	19454	50	TNIK,ZNRF3,MERTK
3.988e-02	-3.22	PAX7 (paired box 7)	protein interactions	5081	123	2	19454	50	TRPS1,NFIA
3.993e-02	-3.22	flippase activity	molecular function	GO:0140327	16	1	18094	46	ATP10B
3.993e-02	-3.22	misfolded protein binding	molecular function	GO:0051787	16	1	18094	46	CLU
4.010e-02	-3.22	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	3	16828	48	APC,APOE,GLI3
4.017e-02	-3.21	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	5	16828	48	FOLH1,MERTK,FGFR2,APC,TNIK
4.035e-02	-3.21	METTL6 (methyltransferase 6, tRNA N3-cytidine)	protein interactions	131965	16	1	19454	50	PDLIM5
4.035e-02	-3.21	Sumo3 (small ubiquitin-like modifier 3)	protein interactions	20610	16	1	19454	50	ITPR2
4.035e-02	-3.21	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	50	APOE
4.035e-02	-3.21	APC2 (APC regulator of WNT signaling pathway 2)	protein interactions	10297	16	1	19454	50	APC
4.035e-02	-3.21	BOK (BCL2 family apoptosis regulator BOK)	protein interactions	666	16	1	19454	50	IRAG1
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	IFFO2 (intermediate filament family orphan 2)	protein interactions	126917	16	1	19454	50	FGFR2
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	ZNRF3
4.035e-02	-3.21	NBL1 (NBL1, DAN family BMP antagonist)	protein interactions	4681	16	1	19454	50	LRIG1
4.036e-02	-3.21	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	48	16828	48	NFIA,PDLIM5,APC,GNA14,LUZP2,PREX2,MSI2,ATP13A4,GLIS3,CLU,LSAMP,SLC1A3,IGSF11,LRIG1,TNIK,PTPRZ1,FGFR2,MAML2,PLEKHA7,ABLIM1,ITPR2,TRPS1,FNBP1,ARHGEF26,APOE,CTNND2,TTC28,ATP10B,CDC14A,GULP1,GRAMD1C,PLCB4,SLC1A2,MERTK,ZNRF3,RFX4,QKI,FOLH1,GLI3,TRPM3,PITPNC1,NKAIN3,RPE65,SPAG16,DAAM2,GPC5,ATP1A2,NPAS3
4.053e-02	-3.21	PI-PLC-Y	pfam domains	PF00387	15	1	17795	49	PLCB4
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	DAAM2
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.059e-02	-3.20	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	48	APC,FGFR2,MERTK,TNIK
4.060e-02	-3.20	thyroid-carcinoma-papillary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-papillary_carcinoma	112	2	16828	48	APC,FGFR2
4.060e-02	-3.20	papillary_carcinoma	COSMIC cancer mutations	papillary_carcinoma	112	2	16828	48	APC,FGFR2
4.079e-02	-3.20	SP7 (Sp7 transcription factor)	protein interactions	121340	297	3	19454	50	NFIA,QKI,TRPS1
4.079e-02	-3.20	modulation of chemical synaptic transmission	biological process	GO:0050804	494	4	18204	48	ATP1A2,SLC1A3,IGSF11,APOE
4.105e-02	-3.19	regulation of trans-synaptic signaling	biological process	GO:0099177	495	4	18204	48	SLC1A3,ATP1A2,APOE,IGSF11
4.105e-02	-3.19	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	5	16828	48	TNIK,FGFR2,APC,MERTK,FOLH1
4.107e-02	-3.19	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	50	TNIK
4.113e-02	-3.19	brain development	biological process	GO:0007420	724	5	18204	48	ATP1A2,SLC1A2,RFX4,FGFR2,GLI3
4.113e-02	-3.19	odontogenesis	biological process	GO:0042476	122	2	18204	48	GLI3,FGFR2
4.114e-02	-3.19	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	48	TNIK,MERTK,APC,FGFR2
4.123e-02	-3.19	angioimmunoblastic_T_cell_lymphoma	COSMIC cancer mutations	angioimmunoblastic_T_cell_lymphoma	269	3	16828	48	APC,ITPR2,TTC28
4.138e-02	-3.18	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	48	SLC1A3
4.138e-02	-3.18	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	48	ZNRF3
4.138e-02	-3.18	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	48	SLC1A2
4.138e-02	-3.18	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	48	APOE
4.138e-02	-3.18	neutrophil homeostasis	biological process	GO:0001780	16	1	18204	48	MERTK
4.138e-02	-3.18	natural killer cell differentiation	biological process	GO:0001779	16	1	18204	48	MERTK
4.138e-02	-3.18	nose development	biological process	GO:0043584	16	1	18204	48	GLI3
4.138e-02	-3.18	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	48	ATP1A2
4.138e-02	-3.18	epithelial cell-cell adhesion	biological process	GO:0090136	16	1	18204	48	PLEKHA7
4.138e-02	-3.18	branching involved in salivary gland morphogenesis	biological process	GO:0060445	16	1	18204	48	FGFR2
4.138e-02	-3.18	spinal cord dorsal/ventral patterning	biological process	GO:0021513	16	1	18204	48	GLI3
4.138e-02	-3.18	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	48	ATP1A2
4.138e-02	-3.18	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	48	APOE
4.138e-02	-3.18	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	48	ATP1A2
4.154e-02	-3.18	cell population proliferation	biological process	GO:0008283	726	5	18204	48	ZNRF3,GLI3,FGFR2,NFIA,CLU
4.158e-02	-3.18	intracellular signal transduction	biological process	GO:0035556	1505	8	18204	48	APOE,IRAG1,TNIK,PLCB4,APC,ITPR2,PREX2,ATP1A2
4.166e-02	-3.18	NTPCR (nucleoside-triphosphatase, cancer-related)	protein interactions	84284	126	2	19454	50	FGFR2,MERTK
4.192e-02	-3.17	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	2	16828	48	PREX2,SLC1A2
4.196e-02	-3.17	pituitary-adenoma	COSMIC cancer mutations	pituitary-adenoma	15	1	16828	48	APC
4.196e-02	-3.17	skin-axilla-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-axilla-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	skin-vulva-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-vulva-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	ovary-germ_cell_tumour-yolk_sac_tumour	COSMIC cancer mutations	ovary-germ_cell_tumour-yolk_sac_tumour	15	1	16828	48	APC
4.196e-02	-3.17	skin-hand-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-hand-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	ovary-germ_cell_tumour-dysgerminoma	COSMIC cancer mutations	ovary-germ_cell_tumour-dysgerminoma	15	1	16828	48	APC
4.196e-02	-3.17	right	COSMIC cancer mutations	right	15	1	16828	48	APC
4.196e-02	-3.17	skin-shoulder-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-shoulder-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	tubulovillous	COSMIC cancer mutations	tubulovillous	15	1	16828	48	APC
4.196e-02	-3.17	monophasic	COSMIC cancer mutations	monophasic	15	1	16828	48	APC
4.196e-02	-3.17	skin-foot-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-foot-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	hypothalamus	COSMIC cancer mutations	hypothalamus	15	1	16828	48	QKI
4.196e-02	-3.17	soft_tissue-fibrous_tissue_and_uncertain_origin-synovial_sarcoma-biphasic	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-synovial_sarcoma-biphasic	15	1	16828	48	APC
4.196e-02	-3.17	large_intestine-adenoma-tubulovillous	COSMIC cancer mutations	large_intestine-adenoma-tubulovillous	15	1	16828	48	APC
4.196e-02	-3.17	villous	COSMIC cancer mutations	villous	15	1	16828	48	APC
4.196e-02	-3.17	testis-germ_cell_tumour-embryonal_carcinoma	COSMIC cancer mutations	testis-germ_cell_tumour-embryonal_carcinoma	15	1	16828	48	FGFR2
4.196e-02	-3.17	skin-adnexal_tumour-adenoid_cystic_carcinoma	COSMIC cancer mutations	skin-adnexal_tumour-adenoid_cystic_carcinoma	15	1	16828	48	APC
4.196e-02	-3.17	skin-lower_leg-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-lower_leg-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	large_intestine-adenoma-tubular	COSMIC cancer mutations	large_intestine-adenoma-tubular	15	1	16828	48	APC
4.196e-02	-3.17	soft_tissue-fibrous_tissue_and_uncertain_origin-synovial_sarcoma-monophasic	COSMIC cancer mutations	soft_tissue-fibrous_tissue_and_uncertain_origin-synovial_sarcoma-monophasic	15	1	16828	48	APC
4.196e-02	-3.17	dysgerminoma	COSMIC cancer mutations	dysgerminoma	15	1	16828	48	APC
4.196e-02	-3.17	large_intestine-rectum-adenoma-villous	COSMIC cancer mutations	large_intestine-rectum-adenoma-villous	15	1	16828	48	APC
4.196e-02	-3.17	testis-germ_cell_tumour-mixed	COSMIC cancer mutations	testis-germ_cell_tumour-mixed	15	1	16828	48	APC
4.196e-02	-3.17	large_intestine-colon-adenoma-villous	COSMIC cancer mutations	large_intestine-colon-adenoma-villous	15	1	16828	48	APC
4.196e-02	-3.17	large_intestine-colon-adenoma-tubulovillous	COSMIC cancer mutations	large_intestine-colon-adenoma-tubulovillous	15	1	16828	48	APC
4.196e-02	-3.17	skin-groin-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-groin-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	skin-chest-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-chest-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	lipoma	COSMIC cancer mutations	lipoma	15	1	16828	48	APC
4.196e-02	-3.17	skin-ear-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-ear-adnexal_tumour-malignant_adnexal_tumour	15	1	16828	48	APC
4.196e-02	-3.17	large_intestine-colon-adenoma-tubular	COSMIC cancer mutations	large_intestine-colon-adenoma-tubular	15	1	16828	48	APC
4.206e-02	-3.17	GPROTEINA	prints domains	PR00318	16	1	5227	14	GNA14
4.208e-02	-3.17	endocytosis	biological process	GO:0006897	499	4	18204	48	MERTK,APOE,FNBP1,GULP1
4.219e-02	-3.17	HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)	protein interactions	9146	512	4	19454	50	LRIG1,APC,FGFR2,DAAM2
4.226e-02	-3.16	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	2	19454	50	ABLIM1,APC
4.233e-02	-3.16	skeletal system development	biological process	GO:0001501	500	4	18204	48	TRPS1,GLI3,FGFR2,NFIA
4.235e-02	-3.16	GproteinA_insert	interpro domains	IPR011025	16	1	18521	50	GNA14
4.235e-02	-3.16	Gprotein_alpha_su	interpro domains	IPR001019	16	1	18521	50	GNA14
4.236e-02	-3.16	action potential	biological process	GO:0001508	124	2	18204	48	ATP1A2,GNA14
4.237e-02	-3.16	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	46	PTPRZ1
4.237e-02	-3.16	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	46	PTPRZ1
4.237e-02	-3.16	dipeptidase activity	molecular function	GO:0016805	17	1	18094	46	FOLH1
4.268e-02	-3.15	embryonic organ morphogenesis	biological process	GO:0048562	295	3	18204	48	FGFR2,GLI3,LRIG1
4.268e-02	-3.15	regulation of endocytosis	biological process	GO:0030100	295	3	18204	48	APOE,CLU,MERTK
4.271e-02	-3.15	APC truncation mutants have impaired AXIN binding	REACTOME pathways	R-HSA-5467337	14	1	10285	32	APC
4.271e-02	-3.15	AXIN missense mutants destabilize the destruction complex	REACTOME pathways	R-HSA-5467340	14	1	10285	32	APC
4.271e-02	-3.15	Truncations of AMER1 destabilize the destruction complex	REACTOME pathways	R-HSA-5467348	14	1	10285	32	APC
4.271e-02	-3.15	AXIN mutants destabilize the destruction complex, activating WNT signaling	REACTOME pathways	R-HSA-4839735	14	1	10285	32	APC
4.271e-02	-3.15	AMER1 mutants destabilize the destruction complex	REACTOME pathways	R-HSA-4839748	14	1	10285	32	APC
4.271e-02	-3.15	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	32	ABLIM1
4.271e-02	-3.15	Synthesis of PE	REACTOME pathways	R-HSA-1483213	14	1	10285	32	ETNPPL
4.271e-02	-3.15	truncated APC mutants destabilize the destruction complex	REACTOME pathways	R-HSA-4839744	14	1	10285	32	APC
4.282e-02	-3.15	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	48	TNIK,MERTK,APC,FGFR2
4.282e-02	-3.15	PSD4 (pleckstrin and Sec7 domain containing 4)	protein interactions	23550	17	1	19454	50	GULP1
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1)	protein interactions	3292	17	1	19454	50	PDLIM5
4.282e-02	-3.15	Ctnnb1 (catenin beta 1)	protein interactions	12387	17	1	19454	50	APC
4.282e-02	-3.15	NOTCH4 (notch receptor 4)	protein interactions	4855	17	1	19454	50	MAML2
4.282e-02	-3.15	Pef1 (penta-EF hand domain containing 1)	protein interactions	67898	17	1	19454	50	QKI
4.282e-02	-3.15	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	50	APOE
4.286e-02	-3.15	MYB (MYB proto-oncogene, transcription factor)	protein interactions	4602	128	2	19454	50	TRPS1,NFIA
4.289e-02	-3.15	REM_1	prosite domains	PS51860	13	1	12186	41	FNBP1
4.297e-02	-3.15	mammary gland development	biological process	GO:0030879	125	2	18204	48	GLI3,FGFR2
4.300e-02	-3.15	hydrolase activity, acting on ester bonds	molecular function	GO:0016788	761	5	18094	46	ATP1A2,PLCB4,RPE65,PTPRZ1,CDC14A
4.303e-02	-3.15	positive regulation of nervous system development	biological process	GO:0051962	296	3	18204	48	PTPRZ1,QKI,GLI3
4.311e-02	-3.14	human chr2q34	chromosome location	human chr2q34	23	1	26134	50	SPAG16
4.318e-02	-3.14	G-alpha	pfam domains	PF00503	16	1	17795	49	GNA14
4.321e-02	-3.14	C3orf52 (chromosome 3 open reading frame 52)	protein interactions	79669	304	3	19454	50	FOLH1,ZNRF3,ITPR2
4.340e-02	-3.14	carboxylic acid transport	biological process	GO:0046942	297	3	18204	48	SLC1A2,SLC1A3,APOE
4.344e-02	-3.14	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	2	10285	32	SLC1A2,SLC1A3
4.346e-02	-3.14	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	2	19454	50	ABLIM1,ITPR2
4.358e-02	-3.13	apical dendrite	cellular component	GO:0097440	17	1	19108	50	CLU
4.359e-02	-3.13	ZnF_GATA	smart domains	SM00401	12	1	9717	36	TRPS1
4.359e-02	-3.13	DWA	smart domains	SM00523	12	1	9717	36	NFIA
4.360e-02	-3.13	ear morphogenesis	biological process	GO:0042471	126	2	18204	48	LRIG1,FGFR2
4.360e-02	-3.13	response to ethanol	biological process	GO:0045471	126	2	18204	48	FGFR2,ITPR2
4.364e-02	-3.13	monoatomic cation homeostasis	biological process	GO:0055080	505	4	18204	48	ATP13A4,APOE,SLC1A3,ATP1A2
4.368e-02	-3.13	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	43	DAAM2
4.376e-02	-3.13	organic acid transport	biological process	GO:0015849	298	3	18204	48	SLC1A3,SLC1A2,APOE
4.380e-02	-3.13	Hemostasis	REACTOME pathways	R-HSA-109582	632	5	10285	32	ITPR2,MERTK,IRAG1,CLU,GNA14
4.391e-02	-3.13	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	48	ATP1A2
4.391e-02	-3.13	branch elongation of an epithelium	biological process	GO:0060602	17	1	18204	48	FGFR2
4.391e-02	-3.13	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	48	APOE
4.391e-02	-3.13	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	48	CLU
4.391e-02	-3.13	C-terminal protein amino acid modification	biological process	GO:0018410	17	1	18204	48	FOLH1
4.391e-02	-3.13	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	48	APOE
4.391e-02	-3.13	viral genome replication	biological process	GO:0019079	17	1	18204	48	NFIA
4.391e-02	-3.13	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	48	APOE
4.391e-02	-3.13	microvillus assembly	biological process	GO:0030033	17	1	18204	48	TNIK
4.391e-02	-3.13	protein trimerization	biological process	GO:0070206	17	1	18204	48	SLC1A2
4.391e-02	-3.13	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	48	ATP1A2
4.391e-02	-3.13	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	48	APOE
4.391e-02	-3.13	ureter development	biological process	GO:0072189	17	1	18204	48	NFIA
4.409e-02	-3.12	CDC42 (cell division cycle 42)	protein interactions	998	1280	7	19454	50	SLC1A3,ARHGEF26,FNBP1,PLCB4,PREX2,ITPR2,PLEKHA7
4.436e-02	-3.12	cytoskeleton organization	biological process	GO:0007010	1251	7	18204	48	ABLIM1,CDC14A,DAAM2,PDLIM5,SPAG16,APOE,TNIK
4.444e-02	-3.11	circulatory system process	biological process	GO:0003013	508	4	18204	48	APOE,SLC1A3,SLC1A2,ATP1A2
4.448e-02	-3.11	PDZ	pfam domains	PF00595	122	2	17795	49	PREX2,PDLIM5
4.448e-02	-3.11	cytoskeleton	cellular component	GO:0005856	2412	11	19108	50	GLI3,SPAG16,CLU,ABLIM1,FNBP1,PLEKHA7,TNIK,APC,CDC14A,TTC28,PDLIM5
4.469e-02	-3.11	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-precursor_T_cell_lymphoblastic_lymphoma	16	1	16828	48	APC
4.469e-02	-3.11	embryonal_carcinoma	COSMIC cancer mutations	embryonal_carcinoma	16	1	16828	48	FGFR2
4.469e-02	-3.11	skin-other-neurocristic_hamartoma	COSMIC cancer mutations	skin-other-neurocristic_hamartoma	16	1	16828	48	APC
4.469e-02	-3.11	central_nervous_system-brain-glioma-gliosarcoma	COSMIC cancer mutations	central_nervous_system-brain-glioma-gliosarcoma	16	1	16828	48	APC
4.469e-02	-3.11	serrated_polyp	COSMIC cancer mutations	serrated_polyp	16	1	16828	48	APC
4.469e-02	-3.11	serrated_adenoma	COSMIC cancer mutations	serrated_adenoma	16	1	16828	48	APC
4.469e-02	-3.11	urinary_tract-carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma	16	1	16828	48	APC
4.469e-02	-3.11	large_intestine-colon-serrated_polyp-serrated_adenoma	COSMIC cancer mutations	large_intestine-colon-serrated_polyp-serrated_adenoma	16	1	16828	48	APC
4.469e-02	-3.11	neurocristic_hamartoma	COSMIC cancer mutations	neurocristic_hamartoma	16	1	16828	48	APC
4.469e-02	-3.11	tubular	COSMIC cancer mutations	tubular	16	1	16828	48	APC
4.469e-02	-3.11	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm	16	1	16828	48	APC
4.469e-02	-3.11	skin-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-adnexal_tumour-malignant_adnexal_tumour	16	1	16828	48	APC
4.469e-02	-3.11	skin-leg-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-leg-adnexal_tumour-malignant_adnexal_tumour	16	1	16828	48	APC
4.469e-02	-3.11	vagina	COSMIC cancer mutations	vagina	16	1	16828	48	APC
4.469e-02	-3.11	normal	COSMIC cancer mutations	normal	16	1	16828	48	APC
4.481e-02	-3.11	cadherin binding involved in cell-cell adhesion	molecular function	GO:0098641	18	1	18094	46	PDLIM5
4.481e-02	-3.11	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	46	ITPR2
4.481e-02	-3.11	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	46	APOE
4.485e-02	-3.10	myelination	biological process	GO:0042552	128	2	18204	48	CLU,QKI
4.485e-02	-3.10	embryonic skeletal system development	biological process	GO:0048706	128	2	18204	48	GLI3,FGFR2
4.493e-02	-3.10	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	1	18521	50	PLCB4
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.494e-02	-3.10	human chr1p21.2	chromosome location	human chr1p21.2	24	1	26134	50	CDC14A
4.498e-02	-3.10	protein-folding chaperone binding	molecular function	GO:0051087	133	2	18094	46	CLU,ATP1A2
4.529e-02	-3.09	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	50	APOE
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	FGFR2
4.529e-02	-3.09	Tnks2 (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2)	protein interactions	74493	18	1	19454	50	APC
4.529e-02	-3.09	Csnk1d (casein kinase 1, delta)	protein interactions	104318	18	1	19454	50	APC
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.529e-02	-3.09	DCDC1 (doublecortin domain containing 1)	protein interactions	341019	18	1	19454	50	PDLIM5
4.529e-02	-3.09	CYP17A1 (cytochrome P450 family 17 subfamily A member 1)	protein interactions	1586	18	1	19454	50	APC
4.529e-02	-3.09	MAMDC4 (MAM domain containing 4)	protein interactions	158056	18	1	19454	50	TTC28
4.530e-02	-3.09	STRN (striatin)	protein interactions	6801	132	2	19454	50	APC,TNIK
4.530e-02	-3.09	COPZ1 (COPI coat complex subunit zeta 1)	protein interactions	22818	132	2	19454	50	FGFR2,APC
4.535e-02	-3.09	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	3	19454	50	PLEKHA7,ABLIM1,TNIK
4.569e-02	-3.09	Cholinergic synapse	KEGG pathways	hsa04725	112	2	7161	22	PLCB4,ITPR2
4.569e-02	-3.09	Serotonergic synapse	KEGG pathways	hsa04726	112	2	7161	22	PLCB4,ITPR2
4.570e-02	-3.09	S45 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358751	15	1	10285	32	APC
4.570e-02	-3.09	T41 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358752	15	1	10285	32	APC
4.570e-02	-3.09	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	REACTOME pathways	R-HSA-4839743	15	1	10285	32	APC
4.570e-02	-3.09	Misspliced GSK3beta mutants stabilize beta-catenin	REACTOME pathways	R-HSA-5339716	15	1	10285	32	APC
4.570e-02	-3.09	S33 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358747	15	1	10285	32	APC
4.570e-02	-3.09	S37 mutants of beta-catenin aren't phosphorylated	REACTOME pathways	R-HSA-5358749	15	1	10285	32	APC
4.581e-02	-3.08	PI-PLC-X	pfam domains	PF00388	17	1	17795	49	PLCB4
4.581e-02	-3.08	Carb_anhydrase	pfam domains	PF00194	17	1	17795	49	PTPRZ1
4.591e-02	-3.08	cellular component biogenesis	biological process	GO:0044085	2716	12	18204	48	CDC14A,ABLIM1,APC,TNIK,APOE,SPAG16,SLC1A2,ARHGEF26,TRPM3,RFX4,CLU,PLEKHA7
4.591e-02	-3.08	CDC25B (cell division cycle 25B)	protein interactions	994	133	2	19454	50	CDC14A,PLEKHA7
4.598e-02	-3.08	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	48	CTNND2,PLCB4
4.607e-02	-3.08	ACTN1 (actinin alpha 1)	protein interactions	87	312	3	19454	50	CLU,APC,PDLIM5
4.611e-02	-3.08	axon ensheathment	biological process	GO:0008366	130	2	18204	48	CLU,QKI
4.611e-02	-3.08	ensheathment of neurons	biological process	GO:0007272	130	2	18204	48	CLU,QKI
4.633e-02	-3.07	monoatomic ion homeostasis	biological process	GO:0050801	515	4	18204	48	ATP1A2,SLC1A3,APOE,ATP13A4
4.640e-02	-3.07	Integration of energy metabolism	REACTOME pathways	R-HSA-163685	111	2	10285	32	ITPR2,GNA14
4.643e-02	-3.07	response to misfolded protein	biological process	GO:0051788	18	1	18204	48	CLU
4.643e-02	-3.07	myelin maintenance	biological process	GO:0043217	18	1	18204	48	CLU
4.643e-02	-3.07	morphogenesis of an epithelial fold	biological process	GO:0060571	18	1	18204	48	FGFR2
4.643e-02	-3.07	cell-cell junction maintenance	biological process	GO:0045217	18	1	18204	48	PLEKHA7
4.643e-02	-3.07	regulation of exit from mitosis	biological process	GO:0007096	18	1	18204	48	CDC14A
4.643e-02	-3.07	spinal cord patterning	biological process	GO:0021511	18	1	18204	48	GLI3
4.643e-02	-3.07	receptor catabolic process	biological process	GO:0032801	18	1	18204	48	ZNRF3
4.643e-02	-3.07	negative regulation of platelet activation	biological process	GO:0010544	18	1	18204	48	APOE
4.643e-02	-3.07	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	48	ATP1A2
4.643e-02	-3.07	retinal metabolic process	biological process	GO:0042574	18	1	18204	48	RPE65
4.643e-02	-3.07	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	48	CTNND2
4.648e-02	-3.07	transmembrane transport	biological process	GO:0055085	1264	7	18204	48	ATP13A4,ITPR2,TRPM3,ATP1A2,SLC1A2,SLC1A3,PLCB4
4.653e-02	-3.07	GI Alpha 1, domain 2-like	gene3d domains	1.10.400.10	16	1	14470	43	GNA14
4.653e-02	-3.07	MME (membrane metalloendopeptidase)	protein interactions	4311	134	2	19454	50	FOLH1,IRAG1
4.661e-02	-3.07	cell division	biological process	GO:0051301	516	4	18204	48	TTC28,CDC14A,APC,FGFR2
4.675e-02	-3.06	digestive tract development	biological process	GO:0048565	131	2	18204	48	GLI3,FGFR2
4.675e-02	-3.06	carboxylic acid transmembrane transport	biological process	GO:1905039	131	2	18204	48	SLC1A2,SLC1A3
4.677e-02	-3.06	human chr5q34	chromosome location	human chr5q34	25	1	26134	50	ATP10B
4.681e-02	-3.06	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	2	18094	46	ITPR2,TRPM3
4.710e-02	-3.06	Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME pathways	R-HSA-881907	443	4	10285	32	GNA14,PLCB4,ITPR2,FGFR2
4.716e-02	-3.05	SOX15 (SRY-box transcription factor 15)	protein interactions	6665	135	2	19454	50	NFIA,TRPS1
4.724e-02	-3.05	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	46	ATP1A2
4.739e-02	-3.05	amino acid transport	biological process	GO:0006865	132	2	18204	48	SLC1A2,SLC1A3
4.742e-02	-3.05	lower_extremity	COSMIC cancer mutations	lower_extremity	17	1	16828	48	APC
4.742e-02	-3.05	optic_nerve	COSMIC cancer mutations	optic_nerve	17	1	16828	48	QKI
4.742e-02	-3.05	jejunum	COSMIC cancer mutations	jejunum	17	1	16828	48	APC
4.742e-02	-3.05	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	17	1	16828	48	QKI
4.742e-02	-3.05	NS-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	NS-carcinoma-squamous_cell_carcinoma	17	1	16828	48	APC
4.742e-02	-3.05	small_intestine-jejunum-carcinoma-adenocarcinoma	COSMIC cancer mutations	small_intestine-jejunum-carcinoma-adenocarcinoma	17	1	16828	48	APC
4.742e-02	-3.05	thymoma	COSMIC cancer mutations	thymoma	17	1	16828	48	APC
4.742e-02	-3.05	thymus-thymoma	COSMIC cancer mutations	thymus-thymoma	17	1	16828	48	APC
4.742e-02	-3.05	upper_extremity	COSMIC cancer mutations	upper_extremity	17	1	16828	48	APC
4.742e-02	-3.05	bone-sacrum-chordoma	COSMIC cancer mutations	bone-sacrum-chordoma	17	1	16828	48	APC
4.742e-02	-3.05	liver-other-adenoma	COSMIC cancer mutations	liver-other-adenoma	17	1	16828	48	APC
4.752e-02	-3.05	Leu-rich_rpt_4	interpro domains	IPR025875	18	1	18521	50	LRIG1
4.754e-02	-3.05	ZYX (zyxin)	protein interactions	7791	316	3	19454	50	APC,PDLIM5,ABLIM1
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	CACNA1B (calcium voltage-gated channel subunit alpha1 B)	protein interactions	774	19	1	19454	50	PDLIM5
4.814e-02	-3.03	late endosome	cellular component	GO:0005770	312	3	19108	50	ATP10B,ATP13A4,APOE
4.828e-02	-3.03	seminoma	COSMIC cancer mutations	seminoma	700	5	16828	48	TNIK,PREX2,TRPS1,FGFR2,MERTK
4.844e-02	-3.03	LRR_4	pfam domains	PF12799	18	1	17795	49	LRIG1
4.852e-02	-3.03	cell cortex	cellular component	GO:0005938	313	3	19108	50	ITPR2,FNBP1,FGFR2
4.859e-02	-3.02	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	50	TNIK
4.859e-02	-3.02	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	50	ATP1A2
4.859e-02	-3.02	astrocyte projection	cellular component	GO:0097449	19	1	19108	50	SLC1A2
4.867e-02	-3.02	Thyroid hormone signaling pathway	KEGG pathways	hsa04919	116	2	7161	22	PLCB4,ATP1A2
4.876e-02	-3.02	skin-ear-malignant_melanoma	COSMIC cancer mutations	skin-ear-malignant_melanoma	124	2	16828	48	APC,PLCB4
4.895e-02	-3.02	vocalization behavior	biological process	GO:0071625	19	1	18204	48	GLI3
4.895e-02	-3.02	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	1	18204	48	APOE
4.895e-02	-3.02	female genitalia development	biological process	GO:0030540	19	1	18204	48	MERTK
4.895e-02	-3.02	regulation of neurotransmitter uptake	biological process	GO:0051580	19	1	18204	48	ATP1A2
4.895e-02	-3.02	response to potassium ion	biological process	GO:0035864	19	1	18204	48	ATP1A2
4.895e-02	-3.02	vascular associated smooth muscle cell differentiation	biological process	GO:0035886	19	1	18204	48	QKI
4.895e-02	-3.02	craniofacial suture morphogenesis	biological process	GO:0097094	19	1	18204	48	GLI3
4.895e-02	-3.02	microvillus organization	biological process	GO:0032528	19	1	18204	48	TNIK
4.900e-02	-3.02	Irinotecan Pathway	WikiPathways	WP229	14	1	5310	19	APC
4.905e-02	-3.01	NFIB (nuclear factor I B)	protein interactions	4781	138	2	19454	50	NFIA,TRPS1
4.931e-02	-3.01	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	18	19454	50	MSI2,CLU,QKI,TTC28,TNIK,ITPR2,ATP1A2,CTNND2,GNA14,PDLIM5,LRIG1,LSAMP,FNBP1,SLC1A3,APOE,PITPNC1,APC,PTPRZ1
4.932e-02	-3.01	FH2	prosite domains	PS51444	15	1	12186	41	DAAM2
4.932e-02	-3.01	CNH	prosite domains	PS50219	15	1	12186	41	TNIK
4.932e-02	-3.01	PIPLC_Y_DOMAIN	prosite domains	PS50008	15	1	12186	41	PLCB4
4.934e-02	-3.01	organic acid transmembrane transport	biological process	GO:1903825	135	2	18204	48	SLC1A2,SLC1A3
4.936e-02	-3.01	Alpha carbonic anhydrase	gene3d domains	3.10.200.10	17	1	14470	43	PTPRZ1
4.939e-02	-3.01	PH_DOMAIN	prosite domains	PS50003	246	3	12186	41	ARHGEF26,PLEKHA7,PREX2
4.946e-02	-3.01	ovary-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-small_cell_carcinoma	125	2	16828	48	FGFR2,APC
4.963e-02	-3.00	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	3	16828	48	APC,FGFR2,SLC1A2
4.963e-02	-3.00	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	3	16828	48	SLC1A2,APC,FGFR2
4.966e-02	-3.00	sphingolipid transporter activity	molecular function	GO:0046624	20	1	18094	46	ATP10B
4.968e-02	-3.00	NEFM (neurofilament medium chain)	protein interactions	4741	139	2	19454	50	TNIK,APOE
4.968e-02	-3.00	DUSP22 (dual specificity phosphatase 22)	protein interactions	56940	139	2	19454	50	QKI,GNA14
4.977e-02	-3.00	TRA2A (transformer 2 alpha homolog)	protein interactions	29896	322	3	19454	50	MERTK,FGFR2,NFIA
4.983e-02	-3.00	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	49	FGFR2,MERTK