Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
5.657e-08	-16.69	cell periphery	cellular component	GO:0071944	6020	34	19108	49	GPC5,NRXN1,RYR3,BMPR1B,CDH20,SLC4A4,ATP1A2,SPARCL1,COL5A3,NKAIN3,AQP4,CTNND2,CKB,CTNNA2,LRIG1,DTNA,PREX2,ATP13A4,GPM6A,PARD3B,SLC1A3,GLUL,TNIK,NTM,SLC1A2,HPSE2,CST3,WWOX,PON2,LSAMP,ITPR2,ERBB4,ZNRF3,CLU
5.733e-08	-16.67	nervous system development	biological process	GO:0007399	2185	21	18204	49	CAMK2G,NTM,SOX5,LRIG1,ATP1A2,ERBB4,RORA,CLU,BMPR1B,SLC1A3,NRXN1,TNIK,SLC1A2,CKB,GPM6A,CTNND2,MSI2,LSAMP,QKI,PREX2,CTNNA2
1.086e-07	-16.04	lymph_node	COSMIC cancer mutations	lymph_node	1703	19	16828	49	LSAMP,PARD3B,GPC5,DTNA,CKB,CAMK2G,SOX5,WWOX,ATP13A4,CTNND2,SFXN5,GPM6A,NEBL,SLC1A3,ARHGAP24,TNIK,ITPR2,RYR3,ERBB4
1.092e-07	-16.03	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	3	10285	32	GLUL,SLC1A3,SLC1A2
1.092e-07	-16.03	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	3	10285	32	SLC1A3,SLC1A2,GLUL
3.509e-07	-14.86	multicellular organism development	biological process	GO:0007275	3957	27	18204	49	CKB,CTNND2,CTNNA2,BMPR1B,SLC1A3,NRXN1,TNIK,SLC1A2,SOX5,LRIG1,WWOX,ARHGAP24,GPM6A,MSI2,LSAMP,QKI,PREX2,NEBL,GLUL,CAMK2G,NTM,ERBB4,ATP1A2,RORA,CLU,ZNRF3,CDH20
6.436e-07	-14.26	plasma membrane	cellular component	GO:0005886	5538	31	19108	49	ATP1A2,NKAIN3,SLC4A4,RYR3,CDH20,BMPR1B,NRXN1,GPC5,GPM6A,ATP13A4,DTNA,PREX2,PARD3B,LRIG1,CTNNA2,CKB,CTNND2,AQP4,PON2,SLC1A2,HPSE2,WWOX,CST3,GLUL,TNIK,NTM,SLC1A3,ERBB4,ZNRF3,LSAMP,ITPR2
6.811e-07	-14.20	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	15	16828	49	FBXL7,HPSE2,ATP1A2,BMPR1B,SOX5,CAMK2G,LSAMP,NPAS3,PREX2,NKAIN3,SLC1A2,RYR3,COL5A3,ERBB4,TNIK
6.811e-07	-14.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	15	16828	49	LSAMP,CAMK2G,SOX5,BMPR1B,ATP1A2,FBXL7,HPSE2,TNIK,RYR3,SLC1A2,COL5A3,ERBB4,NPAS3,PREX2,NKAIN3
6.920e-07	-14.18	system development	biological process	GO:0048731	3533	25	18204	49	NRXN1,TNIK,SLC1A2,BMPR1B,SLC1A3,CTNNA2,CKB,CTNND2,LRIG1,WWOX,SOX5,NEBL,LSAMP,QKI,PREX2,GPM6A,ARHGAP24,MSI2,ATP1A2,ERBB4,RORA,CLU,CAMK2G,NTM,GLUL
1.130e-06	-13.69	brainstem	COSMIC cancer mutations	brainstem	3102	24	16828	49	ZNRF3,SLC1A3,PREX2,NKAIN3,NPAS3,ITPR2,ERBB4,SLC1A2,LSAMP,FBXL7,CDH20,TNIK,GPM6A,RORA,RYR3,QKI,GPC5,ZBTB20,CTNND2,HPSE2,ATP13A4,SFXN5,WWOX,SOX5
1.377e-06	-13.50	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	12	16828	49	ATP1A2,HPSE2,FBXL7,SOX5,LSAMP,GPC5,PREX2,NKAIN3,SLC1A2,COL5A3,RYR3,ERBB4
2.063e-06	-13.09	anatomical structure morphogenesis	biological process	GO:0009653	2225	19	18204	49	SLC1A3,BMPR1B,NEBL,TNIK,NRXN1,ARHGAP24,CTNND2,GPM6A,CTNNA2,PREX2,QKI,SOX5,CDH20,WWOX,CLU,RORA,ERBB4,LRIG1,GLUL
2.644e-06	-12.84	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	21	16828	49	ERBB4,RYR3,ITPR2,NKAIN3,PREX2,SLC1A3,RORA,GPM6A,TNIK,ZNRF3,SOX5,SFXN5,CDH20,CTNND2,FBXL7,HPSE2,ATP13A4,ZBTB20,GPC5,QKI,LSAMP
3.226e-06	-12.64	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	19	16828	49	PREX2,NKAIN3,NPAS3,LRIG1,ITPR2,ERBB4,SLC1A2,RYR3,GPM6A,SLC1A3,FBXL7,HPSE2,CTNND2,ATP13A4,NHSL1,BMPR1B,SOX5,GPC5,LSAMP
3.226e-06	-12.64	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	19	16828	49	NKAIN3,PREX2,NPAS3,ITPR2,LRIG1,ERBB4,SLC1A2,RYR3,GPM6A,SLC1A3,HPSE2,FBXL7,CTNND2,ATP13A4,NHSL1,BMPR1B,SOX5,GPC5,LSAMP
3.494e-06	-12.56	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	FBXL7,CTNND2,HPSE2,SOX5,LSAMP,GPC5,QKI,NKAIN3,PREX2,ITPR2,COL5A3,RYR3,ERBB4,NEBL,RORA,SLC1A3
3.494e-06	-12.56	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	RORA,NEBL,SLC1A3,ITPR2,COL5A3,RYR3,ERBB4,PREX2,NKAIN3,LSAMP,QKI,GPC5,SOX5,HPSE2,CTNND2,FBXL7
3.650e-06	-12.52	MAPT (microtubule associated protein tau)	protein interactions	4137	948	12	19454	50	LSAMP,ATP1A2,CTNND2,NTM,TNIK,GPM6A,SLC1A2,SLC1A3,NEBL,CKB,CTNNA2,CLU
3.755e-06	-12.49	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	49	NEBL,SLC1A3,NKAIN3,PREX2,COL5A3,SLC1A2,ERBB4,ITPR2,NRXN1,LSAMP,FBXL7,TNIK,RORA,GPM6A,SLC4A4,RYR3,ZBTB20,NTM,GPC5,GLIS3,ATP13A4,HPSE2,CTNND2,SOX5,BMPR1B,PAMR1
3.755e-06	-12.49	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	49	FBXL7,LSAMP,NRXN1,ITPR2,ERBB4,COL5A3,SLC1A2,NKAIN3,PREX2,SLC1A3,NEBL,BMPR1B,PAMR1,SOX5,CTNND2,HPSE2,ATP13A4,GLIS3,GPC5,NTM,ZBTB20,RYR3,SLC4A4,GPM6A,RORA,TNIK
7.063e-06	-11.86	multicellular organismal process	biological process	GO:0032501	6177	32	18204	49	CAMK2G,NTM,RORA,CLU,ERBB4,ATP1A2,ZNRF3,CDH20,GLUL,NEBL,MSI2,GPM6A,ARHGAP24,LSAMP,PREX2,QKI,SOX5,LRIG1,WWOX,PTGDS,AQP4,RYR3,DTNA,BMPR1B,SLC1A3,SLC4A4,NRXN1,SLC1A2,TNIK,CKB,CTNND2,CTNNA2
7.103e-06	-11.85	neurogenesis	biological process	GO:0022008	1334	14	18204	49	TNIK,NRXN1,SLC1A3,BMPR1B,QKI,CTNNA2,PREX2,GPM6A,CTNND2,ERBB4,CLU,RORA,NTM,SOX5
7.570e-06	-11.79	anatomical structure development	biological process	GO:0048856	5207	29	18204	49	CTNNA2,CKB,CTNND2,NRXN1,SLC1A2,TNIK,COL5A3,SPARCL1,BMPR1B,SLC1A3,LRIG1,WWOX,SOX5,LSAMP,PREX2,QKI,MSI2,ARHGAP24,GPM6A,NEBL,GLUL,CLU,RORA,ATP1A2,ERBB4,ZNRF3,CDH20,CAMK2G,NTM
1.002e-05	-11.51	cerebellum	COSMIC cancer mutations	cerebellum	769	11	16828	49	NEBL,PARD3B,QKI,GPC5,NPAS3,HPSE2,CTNND2,RYR3,ERBB4,ITPR2,NRXN1
1.189e-05	-11.34	cell morphogenesis	biological process	GO:0000902	687	10	18204	49	PREX2,CTNNA2,GPM6A,CTNND2,TNIK,CDH20,NRXN1,CLU,SLC1A3,BMPR1B
1.584e-05	-11.05	developmental process	biological process	GO:0032502	5716	30	18204	49	ZNRF3,CDH20,RORA,CLU,ERBB4,ATP1A2,NTM,CAMK2G,GLUL,NEBL,NHSL1,PREX2,QKI,LSAMP,MSI2,GPM6A,ARHGAP24,WWOX,LRIG1,SOX5,SLC1A2,TNIK,NRXN1,SLC1A3,SPARCL1,COL5A3,BMPR1B,CTNNA2,CTNND2,CKB
1.766e-05	-10.94	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	3	19454	50	CTNND2,NRXN1,CST3
1.779e-05	-10.94	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	21	16828	49	GPC5,PARD3B,LSAMP,SOX5,CTNND2,FBXL7,HPSE2,ATP13A4,SFXN5,GPM6A,SLC1A3,NEBL,ARHGAP24,ZNRF3,ITPR2,LRIG1,ERBB4,SLC1A2,RYR3,PREX2,NKAIN3
1.881e-05	-10.88	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	17	16828	49	SLC4A4,NPAS3,NRXN1,ITPR2,ERBB4,COL5A3,RYR3,ZNRF3,TNIK,GPM6A,NEBL,RORA,HPSE2,BMPR1B,SOX5,PARD3B,ZBTB20
1.907e-05	-10.87	larynx	COSMIC cancer mutations	larynx	1948	17	16828	49	BMPR1B,SOX5,HPSE2,PARD3B,ZBTB20,ITPR2,NRXN1,RYR3,COL5A3,ERBB4,NPAS3,SLC4A4,GPM6A,NEBL,RORA,ZNRF3,TNIK
1.942e-05	-10.85	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	12	19454	50	SLC1A3,QKI,MSI2,NHSL1,SPARCL1,CLU,AQP4,ATP1A2,LSAMP,GPM6A,CAMK2G,SLC4A4
2.260e-05	-10.70	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	18	16828	49	GPC5,LSAMP,SOX5,CDH20,HPSE2,CTNND2,FBXL7,SLC1A3,NEBL,GPM6A,ARHGAP24,ERBB4,SLC1A2,COL5A3,RYR3,ITPR2,NKAIN3,PREX2
2.260e-05	-10.70	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	18	16828	49	SOX5,CDH20,FBXL7,HPSE2,CTNND2,LSAMP,GPC5,SLC1A2,COL5A3,RYR3,ERBB4,ITPR2,NKAIN3,PREX2,NEBL,SLC1A3,GPM6A,ARHGAP24
2.531e-05	-10.58	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	4	10285	32	ITPR2,CAMK2G,ATP1A2,RYR3
2.544e-05	-10.58	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	18	16828	49	ARHGAP24,GPM6A,SLC1A3,NEBL,PREX2,NKAIN3,ITPR2,ERBB4,COL5A3,RYR3,SLC1A2,GPC5,LSAMP,CTNND2,HPSE2,FBXL7,CDH20,SOX5
3.622e-05	-10.23	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	20	16828	49	HPSE2,FBXL7,CTNND2,SFXN5,SOX5,GPC5,PARD3B,LSAMP,PREX2,NKAIN3,ITPR2,LRIG1,ERBB4,RYR3,SLC1A2,ARHGAP24,ZNRF3,GPM6A,SLC1A3,NEBL
3.634e-05	-10.22	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	40	16828	49	FBXL7,CDH20,PON2,CLU,DTNA,PARD3B,LSAMP,PREX2,NKAIN3,NPAS3,NRXN1,ITPR2,MSI2,ERBB4,SLC1A2,COL5A3,ARHGAP24,ZNRF3,SLC1A3,PITPNC1,NEBL,HPSE2,CTNND2,ATP13A4,GLIS3,SFXN5,NHSL1,BMPR1B,SOX5,QKI,GPC5,NTM,ZBTB20,SPARCL1,SLC4A4,LRIG1,RYR3,TNIK,GPM6A,RORA
3.684e-05	-10.21	mouth	COSMIC cancer mutations	mouth	9004	40	16828	49	ZBTB20,GPC5,QKI,NTM,SFXN5,ATP1A2,HPSE2,CTNND2,ATP13A4,WWOX,SOX5,NHSL1,PAMR1,TNIK,CST3,RORA,GPM6A,SLC4A4,RYR3,LRIG1,CLU,CAMK2G,CKB,DTNA,PARD3B,LSAMP,CDH20,FBXL7,ZNRF3,SLC1A3,PITPNC1,NEBL,GLUL,PREX2,NPAS3,ERBB4,COL5A3,SLC1A2,NRXN1,ITPR2
4.245e-05	-10.07	generation of neurons	biological process	GO:0048699	1158	12	18204	49	NRXN1,TNIK,BMPR1B,SLC1A3,PREX2,CTNNA2,GPM6A,CTNND2,RORA,ERBB4,SOX5,NTM
5.002e-05	-9.90	LRRC7 (leucine rich repeat containing 7)	protein interactions	57554	28	3	19454	50	CAMK2G,CTNND2,ERBB4
6.177e-05	-9.69	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	25	16828	49	SPARCL1,RYR3,TNIK,RORA,GPM6A,ATP1A2,ATP13A4,HPSE2,CTNND2,SOX5,GPC5,QKI,PREX2,NKAIN3,SLC1A2,ERBB4,ITPR2,NEBL,SLC1A3,CDH20,FBXL7,CLU,LSAMP,AQP4,DTNA
6.236e-05	-9.68	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	23	16828	49	FBXL7,CDH20,AQP4,LSAMP,CLU,ITPR2,ERBB4,SLC1A2,NKAIN3,PREX2,NEBL,SOX5,HPSE2,CTNND2,ATP13A4,ATP1A2,GPC5,QKI,RYR3,SPARCL1,GPM6A,RORA,TNIK
6.287e-05	-9.67	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	8	16828	49	SFXN5,ATP13A4,CTNND2,RYR3,ERBB4,LSAMP,GPC5,GPM6A
6.504e-05	-9.64	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	34	16828	49	NTM,GPC5,QKI,ZBTB20,ATP13A4,CTNND2,ATP1A2,SFXN5,PAMR1,NHSL1,SOX5,WWOX,TNIK,GPM6A,RORA,CST3,SLC4A4,LRIG1,RYR3,CAMK2G,PARD3B,LSAMP,DTNA,FBXL7,CDH20,ZNRF3,GLUL,NEBL,PITPNC1,PREX2,ITPR2,NRXN1,SLC1A2,ERBB4
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A3,SLC1A2
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A2,SLC1A3
7.061e-05	-9.56	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	49	SLC1A2,SLC1A3
7.061e-05	-9.56	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	49	SLC1A2,SLC1A3
7.070e-05	-9.56	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	49	SLC1A2,ATP1A2,SLC1A3
7.700e-05	-9.47	cell body	cellular component	GO:0044297	556	8	19108	49	SLC1A3,NRXN1,GLUL,BMPR1B,CTNND2,SLC1A2,ATP1A2,GPM6A
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	GPM6A,LSAMP,NTM
8.305e-05	-9.40	cell junction	cellular component	GO:0030054	2224	16	19108	49	CTNND2,PARD3B,CLU,DTNA,GPM6A,ERBB4,CTNNA2,TNIK,CDH20,NRXN1,QKI,SLC1A3,SPARCL1,ATP1A2,ARHGAP24,SLC1A2
8.364e-05	-9.39	vascular transport	biological process	GO:0010232	86	4	18204	49	SLC1A3,SLC4A4,ATP1A2,SLC1A2
8.364e-05	-9.39	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	49	SLC1A3,SLC4A4,ATP1A2,SLC1A2
9.447e-05	-9.27	response to auditory stimulus	biological process	GO:0010996	33	3	18204	49	NRXN1,ATP1A2,SLC1A3
9.646e-05	-9.25	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	9	16828	49	NEBL,PARD3B,NPAS3,CTNND2,HPSE2,ERBB4,RYR3,NRXN1,ITPR2
9.759e-05	-9.23	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	9	16828	49	PARD3B,NEBL,ITPR2,NRXN1,RYR3,ERBB4,CTNND2,HPSE2,NPAS3
1.057e-04	-9.15	D-amino acid transport	biological process	GO:0042940	6	2	18204	49	SLC1A3,SLC1A2
1.057e-04	-9.15	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	49	SLC1A2,SLC1A3
1.064e-04	-9.15	RIH_assoc-dom	interpro domains	IPR013662	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	Ins145_P3_rcpt	interpro domains	IPR014821	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	RIH_dom	interpro domains	IPR000699	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	2	18521	50	ITPR2,RYR3
1.112e-04	-9.10	neuron differentiation	biological process	GO:0030182	1081	11	18204	49	PREX2,CTNNA2,CTNND2,GPM6A,TNIK,RORA,ERBB4,NRXN1,SLC1A3,NTM,BMPR1B
1.152e-04	-9.07	Ins145_P3_rec	pfam domains	PF08709	6	2	17795	50	RYR3,ITPR2
1.152e-04	-9.07	RYDR_ITPR	pfam domains	PF01365	6	2	17795	50	RYR3,ITPR2
1.152e-04	-9.07	RIH_assoc	pfam domains	PF08454	6	2	17795	50	ITPR2,RYR3
1.158e-04	-9.06	glial cell projection	cellular component	GO:0097386	37	3	19108	49	SLC1A2,AQP4,GLUL
1.173e-04	-9.05	adherens junction	cellular component	GO:0005912	188	5	19108	49	CTNNA2,PARD3B,CDH20,CTNND2,ARHGAP24
1.275e-04	-8.97	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	30	16828	49	ARHGAP24,ZNRF3,NEBL,SLC1A3,NPAS3,NKAIN3,PREX2,ITPR2,COL5A3,SLC1A2,ERBB4,CAMK2G,PON2,CLU,LSAMP,AQP4,PARD3B,FBXL7,CDH20,GPM6A,RORA,SPARCL1,RYR3,GPC5,HPSE2,CTNND2,GLIS3,PAMR1,NHSL1,SOX5
1.345e-04	-8.91	Glutamine synthetase/guanido kinase, catalytic domain	gene3d domains	3.30.590.10	6	2	14470	44	GLUL,CKB
1.345e-04	-8.91	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	2	14470	44	ITPR2,RYR3
1.378e-04	-8.89	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	9	18094	48	SLC1A2,ITPR2,SFXN5,SLC4A4,SLC1A3,GPM6A,RYR3,ATP1A2,ATP13A4
1.398e-04	-8.88	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	8	16828	49	LSAMP,GPM6A,GPC5,CTNND2,SFXN5,NKAIN3,SOX5,RYR3
1.435e-04	-8.85	Salivary secretion	KEGG pathways	hsa04970	90	4	7161	22	RYR3,CST3,ITPR2,ATP1A2
1.435e-04	-8.85	Salivary secretion	KEGG pathways	ko04970	90	4	7161	22	ATP1A2,ITPR2,RYR3,CST3
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.522e-04	-8.79	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	34	16828	49	LSAMP,PARD3B,PON2,FBXL7,PITPNC1,SLC1A3,NEBL,NRXN1,ITPR2,ERBB4,COL5A3,SLC1A2,NKAIN3,PREX2,NPAS3,GPC5,QKI,NTM,ZBTB20,NHSL1,PAMR1,WWOX,SOX5,CTNND2,HPSE2,ATP13A4,SFXN5,GLIS3,GPM6A,RORA,TNIK,LRIG1,RYR3,SLC4A4
1.534e-04	-8.78	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	7	18094	48	RYR3,SLC1A2,ITPR2,SLC1A3,SLC4A4,ATP1A2,GPM6A
1.565e-04	-8.76	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	49	RYR3,SLC1A3,SLC1A2
1.610e-04	-8.73	SDF	pfam domains	PF00375	7	2	17795	50	SLC1A3,SLC1A2
1.625e-04	-8.72	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	34	16828	49	CLU,AQP4,LSAMP,PARD3B,CKB,FBXL7,CDH20,ARHGAP24,ZNRF3,GLUL,PITPNC1,NEBL,PREX2,NPAS3,NRXN1,ITPR2,ERBB4,SLC1A2,COL5A3,QKI,NTM,ZBTB20,HPSE2,CTNND2,ATP13A4,SFXN5,ATP1A2,NHSL1,SOX5,CST3,RORA,SLC4A4,LRIG1,RYR3
1.625e-04	-8.72	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	34	16828	49	ARHGAP24,ZNRF3,GLUL,NEBL,PITPNC1,NPAS3,PREX2,ITPR2,NRXN1,SLC1A2,COL5A3,ERBB4,CLU,AQP4,LSAMP,PARD3B,CKB,FBXL7,CDH20,RORA,CST3,SLC4A4,LRIG1,RYR3,NTM,QKI,ZBTB20,ATP13A4,CTNND2,HPSE2,SFXN5,ATP1A2,NHSL1,SOX5
1.820e-04	-8.61	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	3	19108	49	CAMK2G,ITPR2,RYR3
1.841e-04	-8.60	beta-catenin binding	molecular function	GO:0008013	107	4	18094	48	CTNND2,RORA,CDH20,CTNNA2
1.869e-04	-8.58	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	46	16828	49	COL5A3,SLC1A2,NRXN1,NKAIN3,PREX2,PITPNC1,CDH20,FBXL7,LSAMP,AQP4,DTNA,SPARCL1,RORA,GPM6A,TNIK,NHSL1,GLIS3,ATP1A2,ATP13A4,CTNND2,ZBTB20,ERBB4,MSI2,ITPR2,NPAS3,NEBL,SLC1A3,ZNRF3,ARHGAP24,CKB,PARD3B,PON2,CLU,CAMK2G,RYR3,LRIG1,SLC4A4,SOX5,WWOX,PAMR1,BMPR1B,SFXN5,HPSE2,NTM,QKI,GPC5
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	LSAMP,GPM6A,CTNND2,NKAIN3
1.879e-04	-8.58	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	44	SLC1A2,SLC1A3
1.979e-04	-8.53	Gln_synth/guanido_kin_cat_dom	interpro domains	IPR014746	8	2	18521	50	GLUL,CKB
2.276e-04	-8.39	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	8	18094	48	RYR3,ATP1A2,ATP13A4,ITPR2,SLC1A2,SLC1A3,SLC4A4,GPM6A
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	NTM,LSAMP
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.409e-04	-8.33	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	42	SLC1A2,SLC1A3
2.409e-04	-8.33	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	42	SLC1A3,SLC1A2
2.561e-04	-8.27	monoatomic ion transmembrane transport	biological process	GO:0034220	804	9	18204	49	SFXN5,SLC4A4,ATP1A2,SLC1A2,ATP13A4,SLC1A3,ITPR2,RYR3,GPM6A
2.614e-04	-8.25	transporter activity	molecular function	GO:0005215	1211	11	18094	48	GPM6A,SLC1A3,SLC4A4,SFXN5,AQP4,ITPR2,SLC1A2,ATP13A4,ATP1A2,PITPNC1,RYR3
2.655e-04	-8.23	synapse	cellular component	GO:0045202	1473	12	19108	49	SLC1A2,ERBB4,GPM6A,DTNA,ATP1A2,CLU,SPARCL1,SLC1A3,QKI,NRXN1,CTNND2,TNIK
2.660e-04	-8.23	central nervous system development	biological process	GO:0007417	995	10	18204	49	BMPR1B,SLC1A2,ERBB4,ATP1A2,CLU,RORA,MSI2,CKB,QKI,CTNNA2
2.888e-04	-8.15	EDTRNSPORT	prints domains	PR00173	7	2	5227	20	SLC1A2,SLC1A3
3.013e-04	-8.11	neuron projection morphogenesis	biological process	GO:0048812	486	7	18204	49	GPM6A,CTNND2,PREX2,CTNNA2,BMPR1B,NRXN1,TNIK
3.150e-04	-8.06	cellular response to cocaine	biological process	GO:0071314	10	2	18204	49	SLC1A2,SLC1A3
3.170e-04	-8.06	MIR_motif	interpro domains	IPR016093	10	2	18521	50	ITPR2,RYR3
3.170e-04	-8.06	MIR_dom_sf	interpro domains	IPR036300	10	2	18521	50	RYR3,ITPR2
3.205e-04	-8.05	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	7	18204	49	TNIK,PREX2,CTNNA2,NRXN1,CTNND2,GPM6A,BMPR1B
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	SOX5,RYR3,SLC1A2,PREX2
3.407e-04	-7.98	cell projection morphogenesis	biological process	GO:0048858	496	7	18204	49	BMPR1B,TNIK,NRXN1,GPM6A,CTNND2,PREX2,CTNNA2
3.432e-04	-7.98	MIR	pfam domains	PF02815	10	2	17795	50	RYR3,ITPR2
3.571e-04	-7.94	Glutamatergic synapse	KEGG pathways	ko04724	114	4	7161	22	ITPR2,SLC1A3,SLC1A2,GLUL
3.571e-04	-7.94	Glutamatergic synapse	KEGG pathways	hsa04724	114	4	7161	22	ITPR2,SLC1A2,SLC1A3,GLUL
3.844e-04	-7.86	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	49	SLC1A3,SLC1A2
3.844e-04	-7.86	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	49	SLC1A2,SLC1A3
4.169e-04	-7.78	neuron development	biological process	GO:0048666	859	9	18204	49	NTM,SLC1A3,BMPR1B,TNIK,NRXN1,GPM6A,CTNND2,PREX2,CTNNA2
4.605e-04	-7.68	auditory behavior	biological process	GO:0031223	12	2	18204	49	SLC1A3,NRXN1
4.778e-04	-7.65	sarcolemma	cellular component	GO:0042383	142	4	19108	49	AQP4,DTNA,ATP1A2,RYR3
4.829e-04	-7.64	STRN3 (striatin 3)	protein interactions	29966	142	4	19454	50	TNIK,PON2,ARHGAP24,CAMK2G
4.928e-04	-7.62	NAKATPASE	prints domains	PR00121	9	2	5227	20	ATP13A4,ATP1A2
5.128e-04	-7.58	MIR	prosite domains	PS50919	10	2	12186	42	RYR3,ITPR2
5.266e-04	-7.55	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	8	18094	48	SLC1A2,ITPR2,AQP4,GPM6A,SLC4A4,SLC1A3,RYR3,ATP1A2
5.428e-04	-7.52	neurotransmitter transport	biological process	GO:0006836	140	4	18204	49	ATP1A2,NRXN1,SLC1A2,SLC1A3
5.507e-04	-7.50	cell development	biological process	GO:0048468	2236	15	18204	49	NTM,ERBB4,CLU,RORA,SLC1A3,BMPR1B,TNIK,NEBL,NRXN1,GPM6A,CTNND2,MSI2,QKI,PREX2,CTNNA2
5.584e-04	-7.49	transmembrane transporter activity	molecular function	GO:0022857	1110	10	18094	48	ATP13A4,ATP1A2,RYR3,GPM6A,SLC4A4,SFXN5,SLC1A3,ITPR2,SLC1A2,AQP4
5.776e-04	-7.46	PLXNA4 (plexin A4)	protein interactions	91584	14	2	19454	50	CLU,GPM6A
5.776e-04	-7.46	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	2	19454	50	ZBTB20,CAMK2G
5.787e-04	-7.45	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	11	16828	49	RORA,GPC5,AQP4,LSAMP,TNIK,WWOX,SOX5,ITPR2,NKAIN3,CTNND2,HPSE2
5.895e-04	-7.44	MIR	smart domains	SM00472	10	2	9717	36	RYR3,ITPR2
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A3,SLC1A2
6.327e-04	-7.37	mechanosensory behavior	biological process	GO:0007638	14	2	18204	49	SLC1A3,NRXN1
6.327e-04	-7.37	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	49	SLC4A4,ATP1A2
6.356e-04	-7.36	adult behavior	biological process	GO:0030534	146	4	18204	49	ATP1A2,NRXN1,SLC1A2,PREX2
6.803e-04	-7.29	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	49	CTNNA2,PREX2,CTNND2
6.865e-04	-7.28	cell differentiation	biological process	GO:0030154	3645	20	18204	49	ERBB4,CLU,RORA,WWOX,CAMK2G,NTM,SOX5,QKI,CTNNA2,PREX2,NHSL1,CTNND2,ARHGAP24,GPM6A,MSI2,NRXN1,TNIK,NEBL,BMPR1B,SLC1A3
6.932e-04	-7.27	cell projection	cellular component	GO:0042995	2398	15	19108	49	BMPR1B,GLUL,NRXN1,SLC1A3,ARHGAP24,ATP1A2,WWOX,SLC1A2,CAMK2G,CTNND2,AQP4,CLU,GPM6A,DTNA,CTNNA2
6.941e-04	-7.27	cellular developmental process	biological process	GO:0048869	3648	20	18204	49	NRXN1,NEBL,TNIK,BMPR1B,SLC1A3,NHSL1,CTNNA2,PREX2,QKI,MSI2,CTNND2,ARHGAP24,GPM6A,CLU,RORA,ERBB4,WWOX,CAMK2G,SOX5,NTM
7.516e-04	-7.19	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	3	10285	32	CAMK2G,ATP1A2,ATP13A4
7.721e-04	-7.17	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	5	18094	48	SLC1A2,SLC1A3,ATP1A2,SLC4A4,ATP13A4
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	SLC1A2,SLC1A3,ATP1A2,SLC4A4
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	LSAMP,ZBTB20
8.111e-04	-7.12	cell adhesion	biological process	GO:0007155	942	9	18204	49	PARD3B,NTM,SPARCL1,COL5A3,CDH20,NRXN1,CTNND2,CTNNA2,LSAMP
8.421e-04	-7.08	membrane	cellular component	GO:0016020	9220	35	19108	49	ITPR2,CAMK2G,LSAMP,CLU,ZNRF3,ERBB4,NTM,TNIK,GLUL,SLC1A3,PON2,WWOX,CST3,HPSE2,SLC1A2,CTNND2,AQP4,PARD3B,PTGDS,ATP13A4,GPM6A,DTNA,PREX2,SFXN5,CTNNA2,LRIG1,CKB,BMPR1B,RYR3,CDH20,NRXN1,GPC5,NKAIN3,ATP1A2,SLC4A4
8.632e-04	-7.05	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	7	18094	48	SLC1A2,ITPR2,GPM6A,SLC4A4,SLC1A3,RYR3,ATP1A2
8.637e-04	-7.05	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	8	10285	32	AQP4,RYR3,ATP1A2,CAMK2G,SLC4A4,SLC1A2,ATP13A4,SLC1A3
8.727e-04	-7.04	intracellular chemical homeostasis	biological process	GO:0055082	581	7	18204	49	ATP13A4,ZBTB20,SLC1A3,ATP1A2,SLC4A4,AQP4,RYR3
8.975e-04	-7.02	presynaptic membrane	cellular component	GO:0042734	168	4	19108	49	NRXN1,SLC1A2,ERBB4,GPM6A
9.275e-04	-6.98	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	4	10285	32	RYR3,ATP1A2,CAMK2G,ITPR2
9.332e-04	-6.98	bone	COSMIC cancer mutations	bone	8157	35	16828	49	LSAMP,PARD3B,DTNA,PON2,PTGDS,CAMK2G,COL5A3,ERBB4,ITPR2,NRXN1,NPAS3,PREX2,NKAIN3,NEBL,SLC1A3,GLUL,SOX5,PAMR1,SFXN5,GLIS3,ATP1A2,ATP13A4,HPSE2,CTNND2,ZBTB20,GPC5,QKI,RYR3,LRIG1,SLC4A4,SPARCL1,RORA,CST3,GPM6A,TNIK
9.557e-04	-6.95	monoatomic ion transport	biological process	GO:0006811	964	9	18204	49	ITPR2,SLC1A3,ATP13A4,SLC1A2,SFXN5,SLC4A4,ATP1A2,RYR3,GPM6A
9.592e-04	-6.95	humerus	COSMIC cancer mutations	humerus	546	7	16828	49	SOX5,NKAIN3,SFXN5,NEBL,GPC5,GPM6A,PARD3B
9.767e-04	-6.93	sarcoplasmic reticulum	cellular component	GO:0016529	76	3	19108	49	ITPR2,CAMK2G,RYR3
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	NTM,LSAMP,GPM6A
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A2,SLC1A3
1.026e-03	-6.88	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	2	18094	48	ITPR2,RYR3
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP13A4,ATP1A2
1.071e-03	-6.84	astrocyte projection	cellular component	GO:0097449	19	2	19108	49	SLC1A2,AQP4
1.077e-03	-6.83	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	2	19454	50	DTNA,ARHGAP24
1.150e-03	-6.77	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	50	ATP1A2,ATP13A4
1.158e-03	-6.76	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	6	18204	49	PREX2,CTNNA2,NRXN1,SLC1A3,CTNND2,BMPR1B
1.179e-03	-6.74	cartilage condensation	biological process	GO:0001502	19	2	18204	49	BMPR1B,SOX5
1.181e-03	-6.74	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	20	16828	49	LSAMP,PARD3B,DTNA,GPC5,CLU,BMPR1B,PAMR1,CTNND2,HPSE2,FBXL7,PITPNC1,SLC1A3,TNIK,ZNRF3,RYR3,ERBB4,MSI2,NPAS3,SLC4A4,PREX2
1.181e-03	-6.74	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	20	16828	49	RYR3,ERBB4,MSI2,NPAS3,SLC4A4,PREX2,SLC1A3,PITPNC1,ZNRF3,TNIK,PAMR1,BMPR1B,CTNND2,HPSE2,FBXL7,LSAMP,PARD3B,GPC5,DTNA,CLU
1.194e-03	-6.73	PON1 (paraoxonase 1)	protein interactions	5444	20	2	19454	50	CLU,SFXN5
1.209e-03	-6.72	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	42	16828	49	CST3,RORA,TNIK,LRIG1,RYR3,SLC4A4,QKI,GPC5,NTM,ZBTB20,NHSL1,PAMR1,BMPR1B,WWOX,SOX5,HPSE2,CTNND2,ATP13A4,SFXN5,ATP1A2,GLIS3,GLUL,SLC1A3,NEBL,ARHGAP24,ZNRF3,NRXN1,ITPR2,MSI2,ERBB4,COL5A3,SLC1A2,PREX2,NPAS3,DTNA,LSAMP,PARD3B,CAMK2G,PTGDS,CLU,FBXL7,CDH20
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC1A2,SLC1A3,SLC4A4
1.257e-03	-6.68	Bile secretion	KEGG pathways	ko04976	71	3	7161	22	SLC4A4,AQP4,ATP1A2
1.257e-03	-6.68	Bile secretion	KEGG pathways	hsa04976	71	3	7161	22	ATP1A2,AQP4,SLC4A4
1.290e-03	-6.65	plasma membrane region	cellular component	GO:0098590	1278	10	19108	49	GPM6A,ATP1A2,PARD3B,SLC1A2,ERBB4,SLC4A4,TNIK,AQP4,SLC1A3,NRXN1
1.307e-03	-6.64	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	49	SLC1A2,SLC1A3
1.307e-03	-6.64	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	49	BMPR1B,SOX5
1.318e-03	-6.63	HTR2A (5-hydroxytryptamine receptor 2A)	protein interactions	3356	21	2	19454	50	PON2,GLUL
1.384e-03	-6.58	extracellular region	cellular component	GO:0005576	4350	21	19108	49	SPARCL1,COL5A3,ATP1A2,PON2,SLC4A4,CST3,HPSE2,PAMR1,NTM,TNIK,GLUL,NEBL,GPC5,PTGDS,CLU,GPM6A,LRIG1,ERBB4,CKB,LSAMP,AQP4
1.443e-03	-6.54	positive regulation of purine nucleotide catabolic process	biological process	GO:0033123	21	2	18204	49	SLC4A4,ZBTB20
1.443e-03	-6.54	cell aggregation	biological process	GO:0098743	21	2	18204	49	BMPR1B,SOX5
1.443e-03	-6.54	positive regulation of glycolytic process	biological process	GO:0045821	21	2	18204	49	SLC4A4,ZBTB20
1.443e-03	-6.54	positive regulation of nucleotide catabolic process	biological process	GO:0030813	21	2	18204	49	ZBTB20,SLC4A4
1.444e-03	-6.54	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	5	19454	50	DTNA,CTNNA2,NEBL,TNIK,NHSL1
1.467e-03	-6.52	cellular response to organic cyclic compound	biological process	GO:0071407	464	6	18204	49	ATP1A2,RORA,SLC1A2,RYR3,SLC1A3,ITPR2
1.473e-03	-6.52	Gastric acid secretion	KEGG pathways	ko04971	75	3	7161	22	ITPR2,ATP1A2,CAMK2G
1.473e-03	-6.52	Gastric acid secretion	KEGG pathways	hsa04971	75	3	7161	22	ITPR2,ATP1A2,CAMK2G
1.474e-03	-6.52	monoatomic cation transmembrane transport	biological process	GO:0098655	636	7	18204	49	SLC1A3,ITPR2,ATP13A4,SLC4A4,ATP1A2,GPM6A,RYR3
1.499e-03	-6.50	neuronal cell body	cellular component	GO:0043025	489	6	19108	49	GPM6A,ATP1A2,BMPR1B,CTNND2,NRXN1,SLC1A3
1.550e-03	-6.47	Cation_ATPase_N	smart domains	SM00831	16	2	9717	36	ATP1A2,ATP13A4
1.582e-03	-6.45	Rbm38 (RNA binding motif protein 38)	protein interactions	56190	23	2	19454	50	QKI,MSI2
1.582e-03	-6.45	TIMM10B (translocase of inner mitochondrial membrane 10B)	protein interactions	26515	23	2	19454	50	HPSE2,MSI2
1.584e-03	-6.45	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	49	SLC1A3,ATP1A2
1.663e-03	-6.40	CAMK2D (calcium/calmodulin dependent protein kinase II delta)	protein interactions	817	198	4	19454	50	ITPR2,PON2,WWOX,CAMK2G
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A2,SLC1A3
1.708e-03	-6.37	transmembrane transport	biological process	GO:0055085	1264	10	18204	49	AQP4,RYR3,GPM6A,ATP13A4,SLC1A3,ITPR2,ATP1A2,SLC4A4,SFXN5,SLC1A2
1.751e-03	-6.35	neuron projection	cellular component	GO:0043005	1331	10	19108	49	BMPR1B,CTNND2,CAMK2G,SLC1A3,DTNA,ATP1A2,GPM6A,CLU,CTNNA2,SLC1A2
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	CAMK2G,DTNA,RYR3,ATP1A2
1.758e-03	-6.34	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	27	16828	49	SLC4A4,LRIG1,RYR3,GPM6A,CST3,CTNND2,HPSE2,ATP13A4,ATP1A2,PAMR1,SOX5,GPC5,NTM,NKAIN3,NPAS3,ITPR2,ERBB4,COL5A3,ZNRF3,SLC1A3,NEBL,FBXL7,CDH20,CLU,DTNA,PARD3B,LSAMP
1.758e-03	-6.34	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	27	16828	49	CDH20,FBXL7,LSAMP,PARD3B,DTNA,CLU,COL5A3,ERBB4,ITPR2,NPAS3,NKAIN3,NEBL,SLC1A3,ZNRF3,SOX5,PAMR1,ATP1A2,ATP13A4,HPSE2,CTNND2,NTM,GPC5,RYR3,LRIG1,SLC4A4,CST3,GPM6A
1.774e-03	-6.33	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	5	16828	49	SOX5,GPC5,GPM6A,SFXN5,NKAIN3
1.781e-03	-6.33	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	49	PAMR1,BMPR1B,NHSL1,SOX5,ATP13A4,HPSE2,CTNND2,ATP1A2,GLIS3,SFXN5,NTM,QKI,GPC5,ZBTB20,LRIG1,RYR3,SLC4A4,RORA,CST3,TNIK,FBXL7,CDH20,PARD3B,LSAMP,DTNA,PTGDS,CAMK2G,CLU,ITPR2,NRXN1,COL5A3,SLC1A2,MSI2,ERBB4,NPAS3,PREX2,GLUL,NEBL,SLC1A3,ARHGAP24,ZNRF3
1.832e-03	-6.30	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	48	ATP1A2,ATP13A4
1.832e-03	-6.30	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	48	ATP13A4,ATP1A2
1.848e-03	-6.29	cell surface	cellular component	GO:0009986	896	8	19108	49	CLU,ATP1A2,SLC4A4,SLC1A2,NRXN1,GPC5,AQP4,SLC1A3
1.866e-03	-6.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	9	16828	49	SOX5,WWOX,ITPR2,NKAIN3,CTNND2,HPSE2,RORA,LSAMP,GPC5
1.898e-03	-6.27	HS-GAG degradation	REACTOME pathways	R-HSA-2024096	21	2	10285	32	GPC5,HPSE2
1.911e-03	-6.26	cell-cell junction	cellular component	GO:0005911	513	6	19108	49	CTNNA2,CTNND2,ARHGAP24,CDH20,ATP1A2,PARD3B
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr4q21.23-q21.3	chromosome location	human chr4q21.23-q21.3	1	1	26134	50	ARHGAP24
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr16q23.1-q23.2	chromosome location	human chr16q23.1-q23.2	1	1	26134	50	WWOX
1.915e-03	-6.26	sarcoplasm	cellular component	GO:0016528	96	3	19108	49	RYR3,ITPR2,CAMK2G
1.960e-03	-6.23	synapse organization	biological process	GO:0050808	333	5	18204	49	SPARCL1,GPM6A,CTNND2,ERBB4,NRXN1
1.987e-03	-6.22	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	3	19454	50	CLU,GLUL,SPARCL1
2.022e-03	-6.20	Calcium signaling pathway	KEGG pathways	hsa04020	181	4	7161	22	CAMK2G,ITPR2,RYR3,ERBB4
2.022e-03	-6.20	Calcium signaling pathway	KEGG pathways	ko04020	181	4	7161	22	CAMK2G,RYR3,ITPR2,ERBB4
2.047e-03	-6.19	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	49	SLC1A3,SLC1A2
2.135e-03	-6.15	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	33	16828	49	SLC1A3,NEBL,ERBB4,COL5A3,SLC1A2,ITPR2,NKAIN3,PREX2,CKB,LSAMP,PON2,CLU,CAMK2G,CDH20,FBXL7,RORA,GPM6A,TNIK,RYR3,LRIG1,SLC4A4,GPC5,QKI,SOX5,NHSL1,BMPR1B,PAMR1,GLIS3,ATP1A2,SFXN5,CTNND2,HPSE2,ATP13A4
2.139e-03	-6.15	scalp	COSMIC cancer mutations	scalp	2110	14	16828	49	COL5A3,ERBB4,NRXN1,SLC4A4,PREX2,RORA,NEBL,SOX5,ATP1A2,ATP13A4,LSAMP,NTM,GPC5,CAMK2G
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	CTNNA2,CDH20,DTNA
2.181e-03	-6.13	HPCAL4 (hippocalcin like 4)	protein interactions	51440	27	2	19454	50	AQP4,GPM6A
2.181e-03	-6.13	MBNL2 (muscleblind like splicing regulator 2)	protein interactions	10150	27	2	19454	50	MSI2,QKI
2.192e-03	-6.12	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	22	SLC4A4,ATP1A2
2.192e-03	-6.12	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	22	SLC4A4,ATP1A2
2.214e-03	-6.11	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	49	SLC1A2,SLC1A3
2.222e-03	-6.11	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	11	16828	49	PITPNC1,QKI,CLU,SLC1A2,NHSL1,PREX2,ATP1A2,SFXN5,SLC4A4,CTNND2,ATP13A4
2.222e-03	-6.11	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	11	16828	49	SLC1A2,NHSL1,SLC4A4,SFXN5,PREX2,ATP1A2,ATP13A4,CTNND2,PITPNC1,QKI,CLU
2.324e-03	-6.06	cellular homeostasis	biological process	GO:0019725	689	7	18204	49	RYR3,AQP4,ZBTB20,SLC1A3,ATP13A4,SLC4A4,ATP1A2
2.345e-03	-6.06	PLAAT4 (phospholipase A and acyltransferase 4)	protein interactions	5920	28	2	19454	50	WWOX,PTGDS
2.401e-03	-6.03	neuron projection development	biological process	GO:0031175	693	7	18204	49	BMPR1B,TNIK,NRXN1,GPM6A,CTNND2,PREX2,CTNNA2
2.467e-03	-6.00	response to alkaloid	biological process	GO:0043279	100	3	18204	49	SLC1A3,RYR3,SLC1A2
2.480e-03	-6.00	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	32	SLC1A3,SLC1A2
2.564e-03	-5.97	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	49	CLU
2.570e-03	-5.96	ZNF780B (zinc finger protein 780B)	protein interactions	163131	1	1	19454	50	ARHGAP24
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	ZNF75D (zinc finger protein 75D)	protein interactions	7626	1	1	19454	50	ARHGAP24
2.570e-03	-5.96	RPS15AP21 (ribosomal protein S15a pseudogene 21)	protein interactions	100271357	1	1	19454	50	WWOX
2.570e-03	-5.96	ZNF880 (zinc finger protein 880)	protein interactions	400713	1	1	19454	50	ARHGAP24
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	ZNF729 (zinc finger protein 729)	protein interactions	100287226	1	1	19454	50	ARHGAP24
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	50	NRXN1
2.570e-03	-5.96	ZNF781 (zinc finger protein 781)	protein interactions	163115	1	1	19454	50	ARHGAP24
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.593e-03	-5.95	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	44	ATP1A2,ATP13A4
2.653e-03	-5.93	internal N(7)-methylguanine-containing RNA reader activity	molecular function	GO:0160089	1	1	18094	48	QKI
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A2,SLC1A3
2.673e-03	-5.92	ligand-gated calcium channel activity	molecular function	GO:0099604	29	2	18094	48	RYR3,ITPR2
2.690e-03	-5.92	CLNK (cytokine dependent hematopoietic cell linker)	protein interactions	116449	30	2	19454	50	GLIS3,WWOX
2.691e-03	-5.92	Nuclear signaling by ERBB4	REACTOME pathways	R-HSA-1251985	25	2	10285	32	WWOX,ERBB4
2.692e-03	-5.92	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	49	CLU
2.692e-03	-5.92	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	49	CLU
2.692e-03	-5.92	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	49	CST3
2.692e-03	-5.92	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	49	ATP1A2
2.692e-03	-5.92	olfactory cortex development	biological process	GO:0021989	1	1	18204	49	ATP1A2
2.692e-03	-5.92	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	49	CST3
2.692e-03	-5.92	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	29	16828	49	GPM6A,TNIK,RYR3,SLC4A4,SPARCL1,ZBTB20,GPC5,WWOX,SOX5,BMPR1B,ATP1A2,GLIS3,SFXN5,HPSE2,CTNND2,ATP13A4,PITPNC1,NEBL,GLUL,ARHGAP24,ERBB4,COL5A3,NRXN1,ITPR2,PREX2,NPAS3,PARD3B,AQP4,FBXL7
2.698e-03	-5.92	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	3	19454	50	ERBB4,MSI2,RYR3
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.700e-03	-5.91	Gln_synth_N_conserv_site	interpro domains	IPR027302	1	1	18521	50	GLUL
2.700e-03	-5.91	WWOX_SDR_c-like	interpro domains	IPR042732	1	1	18521	50	WWOX
2.700e-03	-5.91	STAR_dimer	interpro domains	IPR032377	1	1	18521	50	QKI
2.700e-03	-5.91	Gln_synth_gly_rich_site	interpro domains	IPR027303	1	1	18521	50	GLUL
2.700e-03	-5.91	Quaking_NLS	interpro domains	IPR032367	1	1	18521	50	QKI
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	ZNRF3_Znf_RING	interpro domains	IPR045903	1	1	18521	50	ZNRF3
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	NHSL1,ATP13A4,CTNND2,GLIS3,ATP1A2,ZBTB20,SPARCL1,GPM6A,RORA,TNIK,FBXL7,CDH20,AQP4,LSAMP,DTNA,NRXN1,SLC1A2,COL5A3,PREX2,NKAIN3,GLUL,PITPNC1,BMPR1B,PAMR1,SOX5,WWOX,HPSE2,SFXN5,NTM,GPC5,QKI,LRIG1,RYR3,SLC4A4,CST3,PARD3B,CKB,PTGDS,CAMK2G,CLU,PON2,ITPR2,ERBB4,NPAS3,NEBL,SLC1A3,ARHGAP24,ZNRF3
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	CKB,PARD3B,CLU,PON2,PTGDS,CAMK2G,ERBB4,ITPR2,NPAS3,NEBL,SLC1A3,ZNRF3,ARHGAP24,SOX5,WWOX,BMPR1B,PAMR1,SFXN5,HPSE2,NTM,QKI,GPC5,RYR3,LRIG1,SLC4A4,CST3,CDH20,FBXL7,AQP4,LSAMP,DTNA,COL5A3,SLC1A2,NRXN1,NKAIN3,PREX2,PITPNC1,GLUL,NHSL1,ATP1A2,GLIS3,ATP13A4,CTNND2,ZBTB20,SPARCL1,RORA,GPM6A,TNIK
2.810e-03	-5.87	Quaking_NLS	pfam domains	PF16551	1	1	17795	50	QKI
2.810e-03	-5.87	Gln-synt_N	pfam domains	PF03951	1	1	17795	50	GLUL
2.810e-03	-5.87	STAR_dimer	pfam domains	PF16544	1	1	17795	50	QKI
2.828e-03	-5.87	chemical homeostasis	biological process	GO:0048878	914	8	18204	49	RYR3,AQP4,ZBTB20,SLC1A3,ATP13A4,ATP1A2,RORA,SLC4A4
2.842e-03	-5.86	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	3	19454	50	CKB,BMPR1B,PARD3B
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CDH20,CTNNA2
2.898e-03	-5.84	ErbB4 signaling events	Pathway Interaction DB	erbb4_pathway	32	2	2226	6	WWOX,LRIG1
2.901e-03	-5.84	Pancreatic secretion	KEGG pathways	hsa04972	95	3	7161	22	SLC4A4,ATP1A2,ITPR2
2.901e-03	-5.84	Pancreatic secretion	KEGG pathways	ko04972	95	3	7161	22	ITPR2,ATP1A2,SLC4A4
2.916e-03	-5.84	cell junction organization	biological process	GO:0034330	532	6	18204	49	GPM6A,CTNND2,NRXN1,ERBB4,CDH20,SPARCL1
2.934e-03	-5.83	extracellular matrix	cellular component	GO:0031012	559	6	19108	49	GPC5,HPSE2,LRIG1,CLU,COL5A3,SPARCL1
2.942e-03	-5.83	L-glutamate import	biological process	GO:0051938	30	2	18204	49	SLC1A3,SLC1A2
2.952e-03	-5.83	cellular response to endogenous stimulus	biological process	GO:0071495	1135	9	18204	49	RYR3,BMPR1B,SOX5,ITPR2,SLC1A3,ERBB4,ATP1A2,WWOX,SLC1A2
2.960e-03	-5.82	external encapsulating structure	cellular component	GO:0030312	560	6	19108	49	SPARCL1,CLU,COL5A3,LRIG1,HPSE2,GPC5
3.032e-03	-5.80	pharynx	COSMIC cancer mutations	pharynx	2696	16	16828	49	PITPNC1,PREX2,NPAS3,SLC4A4,SLC1A2,RYR3,CLU,GPC5,QKI,DTNA,PARD3B,CTNND2,ATP13A4,ATP1A2,SFXN5,NHSL1
3.041e-03	-5.80	-	gene3d domains	1.20.5.4010	1	1	14470	44	QKI
3.041e-03	-5.80	-	gene3d domains	6.10.250.880	1	1	14470	44	ERBB4
3.051e-03	-5.79	intracellularly ligand-gated monoatomic ion channel activity	molecular function	GO:0005217	31	2	18094	48	ITPR2,RYR3
3.070e-03	-5.79	Proteoglycans in cancer	KEGG pathways	ko05205	203	4	7161	22	HPSE2,ITPR2,CAMK2G,ERBB4
3.070e-03	-5.79	Proteoglycans in cancer	KEGG pathways	hsa05205	203	4	7161	22	ERBB4,CAMK2G,HPSE2,ITPR2
3.104e-03	-5.78	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	46	16828	49	PTGDS,CAMK2G,CLU,PARD3B,CKB,ARHGAP24,ZNRF3,NEBL,SLC1A3,NPAS3,ITPR2,MSI2,ERBB4,NTM,GPC5,QKI,HPSE2,SFXN5,BMPR1B,PAMR1,SOX5,WWOX,CST3,SLC4A4,LRIG1,RYR3,LSAMP,DTNA,FBXL7,CDH20,GLUL,PITPNC1,NKAIN3,PREX2,NRXN1,COL5A3,SLC1A2,ZBTB20,ATP13A4,CTNND2,ATP1A2,GLIS3,NHSL1,TNIK,GPM6A,RORA
3.188e-03	-5.75	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	4	19454	50	SOX5,GPM6A,CAMK2G,ITPR2
3.219e-03	-5.74	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	4	16828	49	ATP13A4,SLC4A4,NTM,COL5A3
3.224e-03	-5.74	human chr11p13	chromosome location	human chr11p13	44	2	26134	50	SLC1A2,PAMR1
3.249e-03	-5.73	KATNAL1 (katanin catalytic subunit A1 like 1)	protein interactions	84056	33	2	19454	50	PITPNC1,ARHGAP24
3.326e-03	-5.71	L-glutamine biosynthesis I	BIOCYC pathways	META_GLNSYN-PWY	1	1	902	3	GLUL
3.326e-03	-5.71	glutamine biosynthesis	BIOCYC pathways	HUMAN_GLNSYN-PWY	1	1	902	3	GLUL
3.326e-03	-5.71	glutamate dependent acid resistance	BIOCYC pathways	HUMAN_PWY0-1305	1	1	902	3	GLUL
3.336e-03	-5.70	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	6	19454	50	ERBB4,ITPR2,TNIK,DTNA,CKB,WWOX
3.344e-03	-5.70	positive regulation of ATP metabolic process	biological process	GO:1903580	32	2	18204	49	SLC4A4,ZBTB20
3.344e-03	-5.70	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	49	SOX5,BMPR1B
3.344e-03	-5.70	transepithelial transport	biological process	GO:0070633	32	2	18204	49	SLC1A2,SLC1A3
3.415e-03	-5.68	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	50	ATP13A4,ATP1A2
3.441e-03	-5.67	HAX1 (HCLS1 associated protein X-1)	protein interactions	10456	397	5	19454	50	ITPR2,NTM,CLU,GPM6A,CKB
3.447e-03	-5.67	GLNA_1	prosite domains	PS00180	1	1	12186	42	GLUL
3.447e-03	-5.67	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	42	CLU
3.447e-03	-5.67	GLNA_ATP	prosite domains	PS00181	1	1	12186	42	GLUL
3.447e-03	-5.67	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	42	CLU
3.468e-03	-5.66	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	31	16828	49	NEBL,SLC1A3,SLC1A2,COL5A3,ERBB4,ITPR2,NKAIN3,PREX2,CKB,LSAMP,CLU,PON2,CDH20,FBXL7,RORA,GPM6A,RYR3,LRIG1,SLC4A4,QKI,GPC5,SOX5,PAMR1,BMPR1B,NHSL1,ATP1A2,GLIS3,SFXN5,ATP13A4,HPSE2,CTNND2
3.486e-03	-5.66	dendrite development	biological process	GO:0016358	113	3	18204	49	PREX2,CTNNA2,CTNND2
3.497e-03	-5.66	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	32	RYR3,ATP1A2,CAMK2G,ITPR2
3.548e-03	-5.64	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	10	16828	49	GLIS3,PREX2,ATP1A2,NPAS3,CDH20,CTNND2,SPARCL1,ATP13A4,ERBB4,NEBL
3.588e-03	-5.63	nodular	COSMIC cancer mutations	nodular	1515	11	16828	49	GLIS3,ATP1A2,CDH20,CTNND2,ATP13A4,NEBL,ERBB4,PREX2,SLC4A4,NPAS3,SPARCL1
3.637e-03	-5.62	Cation_ATPase	pfam domains	PF13246	32	2	17795	50	ATP13A4,ATP1A2
3.649e-03	-5.61	TPRA1 (transmembrane protein adipocyte associated 1)	protein interactions	131601	35	2	19454	50	ITPR2,BMPR1B
3.653e-03	-5.61	response to endogenous stimulus	biological process	GO:0009719	1402	10	18204	49	RYR3,ITPR2,SOX5,SLC1A3,BMPR1B,PTGDS,WWOX,SLC1A2,ERBB4,ATP1A2
3.688e-03	-5.60	calcium channel activity	molecular function	GO:0005262	117	3	18094	48	GPM6A,ITPR2,RYR3
3.688e-03	-5.60	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	3	18094	48	SLC4A4,SLC1A3,SLC1A2
3.814e-03	-5.57	Ion channel transport	REACTOME pathways	R-HSA-983712	209	4	10285	32	CAMK2G,RYR3,ATP1A2,ATP13A4
3.826e-03	-5.57	AQUAPORIN4	prints domains	PR02016	1	1	5227	20	AQP4
3.857e-03	-5.56	ZNRF1 (zinc and ring finger 1)	protein interactions	84937	36	2	19454	50	GLUL,ATP1A2
3.857e-03	-5.56	SLC5A5 (solute carrier family 5 member 5)	protein interactions	6528	36	2	19454	50	CAMK2G,SFXN5
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A3,SLC1A2
3.913e-03	-5.54	TGFBR1 (transforming growth factor beta receptor 1)	protein interactions	7046	251	4	19454	50	BMPR1B,CLU,WWOX,PREX2
3.937e-03	-5.54	synapse assembly	biological process	GO:0007416	118	3	18204	49	NRXN1,ERBB4,GPM6A
3.979e-03	-5.53	glutamatergic synapse	cellular component	GO:0098978	412	5	19108	49	SLC1A2,ERBB4,SPARCL1,GPM6A,TNIK
4.007e-03	-5.52	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	31	16828	49	GPM6A,RORA,TNIK,LRIG1,RYR3,SPARCL1,QKI,GPC5,NHSL1,PAMR1,BMPR1B,SOX5,HPSE2,CTNND2,ATP13A4,SFXN5,GLIS3,SLC1A3,NEBL,ITPR2,ERBB4,SLC1A2,COL5A3,PREX2,NKAIN3,PARD3B,LSAMP,PON2,CLU,FBXL7,CDH20
4.070e-03	-5.50	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	13	19108	49	AQP4,CTNND2,CAMK2G,CTNNA2,DTNA,GPM6A,CLU,SLC1A3,GLUL,BMPR1B,SLC1A2,WWOX,ATP1A2
4.071e-03	-5.50	TRNAU1AP (tRNA selenocysteine 1 associated protein 1)	protein interactions	54952	37	2	19454	50	ZBTB20,QKI
4.071e-03	-5.50	PRRG4 (proline rich and Gla domain 4)	protein interactions	79056	37	2	19454	50	NEBL,ERBB4
4.071e-03	-5.50	MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2)	protein interactions	9863	37	2	19454	50	CTNND2,ERBB4
4.071e-03	-5.50	TFAP2C (transcription factor AP-2 gamma)	protein interactions	7022	37	2	19454	50	WWOX,ERBB4
4.071e-03	-5.50	HPCA (hippocalcin)	protein interactions	3208	37	2	19454	50	CST3,GPM6A
4.099e-03	-5.50	proteoglycan binding	molecular function	GO:0043394	36	2	18094	48	COL5A3,HPSE2
4.127e-03	-5.49	striated muscle contraction	biological process	GO:0006941	120	3	18204	49	RYR3,DTNA,ATP1A2
4.138e-03	-5.49	Neuronal System	REACTOME pathways	R-HSA-112316	349	5	10285	32	SLC1A2,NRXN1,SLC1A3,CAMK2G,GLUL
4.183e-03	-5.48	monoatomic cation transport	biological process	GO:0006812	766	7	18204	49	GPM6A,RYR3,SLC1A3,ITPR2,ATP13A4,SLC4A4,ATP1A2
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP13A4,ATP1A2
4.258e-03	-5.46	PAX9 (paired box 9)	protein interactions	5083	127	3	19454	50	ARHGAP24,QKI,WWOX
4.290e-03	-5.45	Pcbp1 (poly(rC) binding protein 1)	protein interactions	23983	38	2	19454	50	QKI,MSI2
4.361e-03	-5.44	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	3	10285	32	SLC1A2,SLC1A3,SLC4A4
4.361e-03	-5.44	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	4	10285	32	GLUL,CAMK2G,SLC1A3,SLC1A2
4.451e-03	-5.41	positive regulation of purine nucleotide metabolic process	biological process	GO:1900544	37	2	18204	49	ZBTB20,SLC4A4
4.451e-03	-5.41	positive regulation of nucleotide metabolic process	biological process	GO:0045981	37	2	18204	49	ZBTB20,SLC4A4
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP13A4,ATP1A2
4.691e-03	-5.36	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	49	SLC1A2,SLC1A3
4.753e-03	-5.35	endoplasmic reticulum	cellular component	GO:0005783	2051	12	19108	49	CAMK2G,ITPR2,GLUL,RYR3,NRXN1,SPARCL1,PTGDS,COL5A3,CLU,ATP1A2,ATP13A4,CST3
4.936e-03	-5.31	olfactory lobe development	biological process	GO:0021988	39	2	18204	49	ATP1A2,ERBB4
4.936e-03	-5.31	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	49	ATP1A2,SLC1A3
4.980e-03	-5.30	SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3)	protein interactions	9901	41	2	19454	50	TNIK,ARHGAP24
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	ZNF680 (zinc finger protein 680)	protein interactions	340252	2	1	19454	50	ARHGAP24
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	cdh11.S (cadherin 11 S homeolog)	protein interactions	100337621	2	1	19454	50	ERBB4
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	ZNF658B (zinc finger protein 658B (pseudogene))	protein interactions	401509	2	1	19454	50	ARHGAP24
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.299e-03	-5.24	heparanase activity	molecular function	GO:0030305	2	1	18094	48	HPSE2
5.299e-03	-5.24	ammonia ligase activity	molecular function	GO:0016211	2	1	18094	48	GLUL
5.299e-03	-5.24	glutamine synthetase activity	molecular function	GO:0004356	2	1	18094	48	GLUL
5.329e-03	-5.23	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	21	19454	50	ATP1A2,CTNND2,LSAMP,GLUL,LRIG1,GPM6A,CAMK2G,ITPR2,SLC4A4,NTM,TNIK,CST3,SLC1A3,QKI,MSI2,PON2,DTNA,CLU,CKB,PITPNC1,CTNNA2
5.330e-03	-5.23	CUL1 (cullin 1)	protein interactions	8454	838	7	19454	50	MSI2,FBXL7,ARHGAP24,RYR3,CLU,CKB,ZNRF3
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	44	ATP13A4,ATP1A2
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	44	ATP1A2,ATP13A4
5.376e-03	-5.23	Wnt receptor catabolic process	biological process	GO:0038018	2	1	18204	49	ZNRF3
5.376e-03	-5.23	myofibroblast contraction	biological process	GO:1990764	2	1	18204	49	QKI
5.376e-03	-5.23	negative regulation of 3'-UTR-mediated mRNA stabilization	biological process	GO:1905869	2	1	18204	49	QKI
5.376e-03	-5.23	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	49	CLU
5.376e-03	-5.23	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	49	CST3
5.376e-03	-5.23	glutamine biosynthetic process	biological process	GO:0006542	2	1	18204	49	GLUL
5.376e-03	-5.23	futile creatine cycle	biological process	GO:0140651	2	1	18204	49	CKB
5.376e-03	-5.23	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	49	CST3
5.376e-03	-5.23	establishment of planar polarity involved in nephron morphogenesis	biological process	GO:0072046	2	1	18204	49	ERBB4
5.377e-03	-5.23	somatodendritic compartment	cellular component	GO:0036477	842	7	19108	49	CTNND2,BMPR1B,NRXN1,SLC1A3,CLU,GPM6A,ATP1A2
5.383e-03	-5.22	amino acid transport	biological process	GO:0006865	132	3	18204	49	SLC1A3,SLC1A2,SFXN5
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	ZNRF-3_ecto	interpro domains	IPR040700	2	1	18521	50	ZNRF3
5.392e-03	-5.22	Par3/HAL_N	interpro domains	IPR021922	2	1	18521	50	PARD3B
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	Glyco_hydro_79	interpro domains	IPR005199	2	1	18521	50	HPSE2
5.392e-03	-5.22	Gln_synt_N_sf	interpro domains	IPR036651	2	1	18521	50	GLUL
5.392e-03	-5.22	Gln_synt_N	interpro domains	IPR008147	2	1	18521	50	GLUL
5.392e-03	-5.22	Gln_synth_cat_dom	interpro domains	IPR008146	2	1	18521	50	GLUL
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Paraoxonase2	interpro domains	IPR008364	2	1	18521	50	PON2
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.432e-03	-5.22	Ig_I-set	interpro domains	IPR013098	132	3	18521	50	LSAMP,NTM,LRIG1
5.492e-03	-5.20	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	4	18094	48	SLC1A2,SLC1A3,SFXN5,SLC4A4
5.497e-03	-5.20	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	49	ATP1A2,RYR3,ITPR2
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A2,SLC1A3
5.612e-03	-5.18	ZNRF_3_ecto	pfam domains	PF18212	2	1	17795	50	ZNRF3
5.612e-03	-5.18	Gln-synt_C	pfam domains	PF00120	2	1	17795	50	GLUL
5.612e-03	-5.18	Glyco_hydro_79n	pfam domains	PF03662	2	1	17795	50	HPSE2
5.612e-03	-5.18	Clusterin	pfam domains	PF01093	2	1	17795	50	CLU
5.612e-03	-5.18	Par3_HAL_N_term	pfam domains	PF12053	2	1	17795	50	PARD3B
5.612e-03	-5.18	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	48	GPM6A,ITPR2,RYR3
5.706e-03	-5.17	cellular modified amino acid biosynthetic process	biological process	GO:0042398	42	2	18204	49	CKB,SLC1A2
5.717e-03	-5.16	SH2D1A (SH2 domain containing 1A)	protein interactions	4068	44	2	19454	50	CAMK2G,ERBB4
5.721e-03	-5.16	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	5	18204	49	SLC1A3,RYR3,ATP13A4,SLC4A4,ATP1A2
5.802e-03	-5.15	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	4	16828	49	HPSE2,NPAS3,GPC5,ERBB4
5.802e-03	-5.15	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	4	16828	49	ERBB4,GPC5,NPAS3,HPSE2
6.018e-03	-5.11	carboxylic acid biosynthetic process	biological process	GO:0046394	271	4	18204	49	QKI,PTGDS,GLUL,SLC1A3
6.044e-03	-5.11	inorganic cation transmembrane transport	biological process	GO:0098662	618	6	18204	49	SLC4A4,ATP1A2,ITPR2,SLC1A3,GPM6A,RYR3
6.064e-03	-5.11	I-set	pfam domains	PF07679	132	3	17795	50	LRIG1,NTM,LSAMP
6.073e-03	-5.10	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	44	CTNNA2
6.073e-03	-5.10	-	gene3d domains	6.20.350.10	2	1	14470	44	RYR3
6.073e-03	-5.10	Glutamine synthetase, N-terminal domain	gene3d domains	3.10.20.70	2	1	14470	44	GLUL
6.084e-03	-5.10	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	20	16828	49	ERBB4,SLC1A2,COL5A3,RYR3,PREX2,SLC4A4,NPAS3,GPM6A,PITPNC1,NEBL,ZNRF3,TNIK,NHSL1,CTNND2,FBXL7,ATP1A2,GLIS3,AQP4,PARD3B,CAMK2G
6.174e-03	-5.09	vascular process in circulatory system	biological process	GO:0003018	273	4	18204	49	ATP1A2,SLC4A4,SLC1A2,SLC1A3
6.238e-03	-5.08	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	5	18204	49	SLC1A3,RYR3,ATP13A4,SLC4A4,ATP1A2
6.254e-03	-5.07	organic acid biosynthetic process	biological process	GO:0016053	274	4	18204	49	GLUL,QKI,PTGDS,SLC1A3
6.257e-03	-5.07	active transmembrane transporter activity	molecular function	GO:0022804	444	5	18094	48	SLC1A2,SLC4A4,ATP1A2,SLC1A3,ATP13A4
6.288e-03	-5.07	basal plasma membrane	cellular component	GO:0009925	288	4	19108	49	AQP4,SLC1A3,ERBB4,SLC4A4
6.500e-03	-5.04	LRIG3 (leucine rich repeats and immunoglobulin like domains 3)	protein interactions	121227	47	2	19454	50	LRIG1,ERBB4
6.527e-03	-5.03	acidic amino acid transport	biological process	GO:0015800	45	2	18204	49	SLC1A2,SLC1A3
6.588e-03	-5.02	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	49	SLC1A3,SLC1A2,SLC4A4
6.624e-03	-5.02	metal ion transport	biological process	GO:0030001	630	6	18204	49	SLC4A4,ATP1A2,ITPR2,SLC1A3,GPM6A,RYR3
6.645e-03	-5.01	L-glutamate and L-glutamine biosynthesis	BIOCYC pathways	META_PWY-5505	2	1	902	3	GLUL
6.757e-03	-5.00	CPVL (carboxypeptidase vitellogenic like)	protein interactions	54504	150	3	19454	50	TNIK,WWOX,SOX5
6.783e-03	-4.99	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	42	ATP1A2,ATP13A4
6.882e-03	-4.98	GS_CATALYTIC	prosite domains	PS51987	2	1	12186	42	GLUL
6.882e-03	-4.98	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	42	SPARCL1
6.882e-03	-4.98	GS_BETA_GRASP	prosite domains	PS51986	2	1	12186	42	GLUL
6.882e-03	-4.98	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	42	SPARCL1
6.997e-03	-4.96	Wnt signaling pathway	biological process	GO:0016055	283	4	18204	49	ZNRF3,TNIK,WWOX,CTNND2
7.007e-03	-4.96	CAMK2B (calcium/calmodulin dependent protein kinase II beta)	protein interactions	816	152	3	19454	50	CAMK2G,GPM6A,ITPR2
7.009e-03	-4.96	response to organic cyclic compound	biological process	GO:0014070	843	7	18204	49	RYR3,ITPR2,SLC1A3,ATP1A2,RORA,PTGDS,SLC1A2
7.087e-03	-4.95	symporter activity	molecular function	GO:0015293	148	3	18094	48	SLC1A2,SLC4A4,SLC1A3
7.119e-03	-4.94	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	4	16828	49	PREX2,SLC1A2,SOX5,RYR3
7.170e-03	-4.94	cell junction assembly	biological process	GO:0034329	285	4	18204	49	GPM6A,CDH20,NRXN1,ERBB4
7.253e-03	-4.93	central_nervous_system-brainstem-glioma-astrocytoma_Grade_II	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_II	136	3	16828	49	PREX2,WWOX,ERBB4
7.272e-03	-4.92	Ig_3	pfam domains	PF13927	141	3	17795	50	LSAMP,NTM,LRIG1
7.396e-03	-4.91	CLa	smart domains	SM00035	2	1	9717	36	CLU
7.396e-03	-4.91	CLb	smart domains	SM00030	2	1	9717	36	CLU
7.396e-03	-4.91	Gln-synt_C	smart domains	SM01230	2	1	9717	36	GLUL
7.423e-03	-4.90	IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1)	protein interactions	10642	477	5	19454	50	QKI,MSI2,ARHGAP24,WWOX,SOX5
7.519e-03	-4.89	neuromuscular process	biological process	GO:0050905	149	3	18204	49	SLC1A3,CTNNA2,NRXN1
7.617e-03	-4.88	LINGO1 (leucine rich repeat and Ig domain containing 1)	protein interactions	84894	51	2	19454	50	NTM,PON2
7.639e-03	-4.87	PARAOXONASE2	prints domains	PR01787	2	1	5227	20	PON2
7.657e-03	-4.87	CARM1 (coactivator associated arginine methyltransferase 1)	protein interactions	10498	304	4	19454	50	QKI,RORA,DTNA,CAMK2G
7.674e-03	-4.87	CATATPASE	prints domains	PR00119	35	2	5227	20	ATP1A2,ATP13A4
7.691e-03	-4.87	ZNF716 (zinc finger protein 716)	protein interactions	441234	3	1	19454	50	ARHGAP24
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Lrrc7 (leucine rich repeat containing 7)	protein interactions	117284	3	1	19454	50	CAMK2G
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	ZNF257 (zinc finger protein 257)	protein interactions	113835	3	1	19454	50	ARHGAP24
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	50	NRXN1
7.691e-03	-4.87	NRG3 (neuregulin 3)	protein interactions	10718	3	1	19454	50	ERBB4
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.691e-03	-4.87	ZNF506 (zinc finger protein 506)	protein interactions	440515	3	1	19454	50	ARHGAP24
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Hk2 (hexokinase 2)	protein interactions	25059	3	1	19454	50	PTGDS
7.691e-03	-4.87	ZNF682 (zinc finger protein 682)	protein interactions	91120	3	1	19454	50	ARHGAP24
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	ZNF540 (zinc finger protein 540)	protein interactions	163255	3	1	19454	50	ARHGAP24
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.792e-03	-4.85	NPEPPS (aminopeptidase puromycin sensitive)	protein interactions	9520	158	3	19454	50	CKB,WWOX,ARHGAP24
7.821e-03	-4.85	Signaling by ERBB4	REACTOME pathways	R-HSA-1236394	43	2	10285	32	WWOX,ERBB4
7.847e-03	-4.85	basal part of cell	cellular component	GO:0045178	307	4	19108	49	SLC1A3,AQP4,ERBB4,SLC4A4
7.909e-03	-4.84	SNAP91 (synaptosome associated protein 91)	protein interactions	9892	52	2	19454	50	ERBB4,GPM6A
7.938e-03	-4.84	acyl-L-homoserine-lactone lactonohydrolase activity	molecular function	GO:0102007	3	1	18094	48	PON2
7.938e-03	-4.84	prostaglandin-D synthase activity	molecular function	GO:0004667	3	1	18094	48	PTGDS
7.938e-03	-4.84	epidermal growth factor receptor activity	molecular function	GO:0005006	3	1	18094	48	ERBB4
7.938e-03	-4.84	inositol 1,4,5-trisphosphate-gated calcium channel activity	molecular function	GO:0005220	3	1	18094	48	ITPR2
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.938e-03	-4.84	lactonohydrolase activity	molecular function	GO:0046573	3	1	18094	48	PON2
7.938e-03	-4.84	neuregulin receptor activity	molecular function	GO:0038131	3	1	18094	48	ERBB4
7.938e-03	-4.84	acid-ammonia (or amide) ligase activity	molecular function	GO:0016880	3	1	18094	48	GLUL
8.054e-03	-4.82	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	49	NRXN1
8.054e-03	-4.82	immune complex clearance	biological process	GO:0002434	3	1	18204	49	CLU
8.054e-03	-4.82	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	49	CLU
8.054e-03	-4.82	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	49	SLC1A2
8.054e-03	-4.82	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	49	ATP1A2
8.054e-03	-4.82	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	49	NEBL
8.054e-03	-4.82	cysteine transport	biological process	GO:0042883	3	1	18204	49	SLC1A2
8.054e-03	-4.82	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	49	CTNNA2
8.054e-03	-4.82	central nervous system morphogenesis	biological process	GO:0021551	3	1	18204	49	ERBB4
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	TM_ErbB1	interpro domains	IPR049328	3	1	18521	50	ERBB4
8.078e-03	-4.82	InsP3_rcpt	interpro domains	IPR000493	3	1	18521	50	ITPR2
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	Arylesterase	interpro domains	IPR002640	3	1	18521	50	PON2
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.100e-03	-4.82	ITCH (itchy E3 ubiquitin protein ligase)	protein interactions	83737	309	4	19454	50	WWOX,RORA,GLIS3,ERBB4
8.157e-03	-4.81	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	18	16828	49	NHSL1,PAMR1,SOX5,CTNND2,HPSE2,ATP1A2,GPC5,ZBTB20,PON2,LRIG1,COL5A3,RYR3,SPARCL1,PREX2,SLC4A4,GPM6A,NEBL,TNIK
8.206e-03	-4.80	middle_third	COSMIC cancer mutations	middle_third	3533	18	16828	49	SPARCL1,PREX2,SLC4A4,LRIG1,RYR3,COL5A3,TNIK,GPM6A,NEBL,HPSE2,CTNND2,ATP1A2,NHSL1,PAMR1,SOX5,PON2,GPC5,ZBTB20
8.230e-03	-4.80	calcium-mediated signaling	biological process	GO:0019722	154	3	18204	49	ATP1A2,RYR3,ITPR2
8.295e-03	-4.79	endoplasmic reticulum lumen	cellular component	GO:0005788	312	4	19108	49	SPARCL1,COL5A3,CLU,CST3
8.320e-03	-4.79	neuromuscular process controlling balance	biological process	GO:0050885	51	2	18204	49	SLC1A3,NRXN1
8.320e-03	-4.79	positive regulation of extrinsic apoptotic signaling pathway	biological process	GO:2001238	51	2	18204	49	WWOX,BMPR1B
8.343e-03	-4.79	KLRC1 (killer cell lectin like receptor C1)	protein interactions	3821	162	3	19454	50	SFXN5,PON2,LRIG1
8.373e-03	-4.78	ACTN1 (actinin alpha 1)	protein interactions	87	312	4	19454	50	CLU,CKB,NEBL,ARHGAP24
8.406e-03	-4.78	Arylesterase	pfam domains	PF01731	3	1	17795	50	PON2
8.406e-03	-4.78	Myelin_PLP	pfam domains	PF01275	3	1	17795	50	GPM6A
8.406e-03	-4.78	TM_ErbB1	pfam domains	PF21314	3	1	17795	50	ERBB4
8.406e-03	-4.78	RYDR_Jsol	pfam domains	PF21119	3	1	17795	50	RYR3
8.406e-03	-4.78	RR_TM4-6	pfam domains	PF06459	3	1	17795	50	RYR3
8.406e-03	-4.78	RyR	pfam domains	PF02026	3	1	17795	50	RYR3
8.436e-03	-4.78	protein binding	molecular function	GO:0005515	13983	44	18094	48	FBXL7,DTNA,ITPR2,SLC1A2,WWOX,LRIG1,ERBB4,CDH20,SFXN5,CAMK2G,GPC5,ATP1A2,ZNRF3,SLC1A3,PITPNC1,BMPR1B,NRXN1,PARD3B,SOX5,GPM6A,RYR3,HPSE2,ARHGAP24,NTM,CKB,NEBL,TNIK,CTNND2,SPARCL1,SLC4A4,CTNNA2,COL5A3,PON2,CLU,PTGDS,LSAMP,QKI,RORA,NPAS3,GLUL,AQP4,GLIS3,MSI2,CST3
8.507e-03	-4.77	SYNM (synemin)	protein interactions	23336	54	2	19454	50	DTNA,ERBB4
8.638e-03	-4.75	regulation of nucleotide catabolic process	biological process	GO:0030811	52	2	18204	49	SLC4A4,ZBTB20
8.638e-03	-4.75	regulation of glycolytic process	biological process	GO:0006110	52	2	18204	49	SLC4A4,ZBTB20
8.638e-03	-4.75	regulation of purine nucleotide catabolic process	biological process	GO:0033121	52	2	18204	49	ZBTB20,SLC4A4
8.712e-03	-4.74	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	48	ATP13A4,ATP1A2
8.814e-03	-4.73	SYN1 (synapsin I)	protein interactions	6853	55	2	19454	50	GPM6A,CAMK2G
8.814e-03	-4.73	AMPH (amphiphysin)	protein interactions	273	55	2	19454	50	GLUL,GPM6A
8.836e-03	-4.73	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	4	16828	49	ERBB4,ATP1A2,PREX2,TNIK
8.962e-03	-4.71	neutral amino acid transport	biological process	GO:0015804	53	2	18204	49	SLC1A2,SLC1A3
8.962e-03	-4.71	regulation of chondrocyte differentiation	biological process	GO:0032330	53	2	18204	49	BMPR1B,SOX5
8.979e-03	-4.71	monoatomic anion transport	biological process	GO:0006820	159	3	18204	49	SLC4A4,SLC1A2,SLC1A3
9.072e-03	-4.70	TARDBP (TAR DNA binding protein)	protein interactions	23435	501	5	19454	50	MSI2,GLUL,CKB,WWOX,GPM6A
9.095e-03	-4.70	-	gene3d domains	6.10.250.2510	3	1	14470	44	CTNNA2
9.095e-03	-4.70	-	gene3d domains	1.10.490.160	3	1	14470	44	RYR3
9.142e-03	-4.69	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	42	16828	49	GLUL,NEBL,PITPNC1,SLC1A3,ARHGAP24,ZNRF3,ITPR2,NRXN1,SLC1A2,COL5A3,ERBB4,NPAS3,PREX2,LSAMP,PARD3B,DTNA,CKB,PON2,FBXL7,CDH20,GPM6A,RORA,CST3,TNIK,LRIG1,RYR3,SPARCL1,SLC4A4,NTM,GPC5,QKI,ZBTB20,BMPR1B,PAMR1,NHSL1,SOX5,ATP13A4,HPSE2,CTNND2,SFXN5,ATP1A2,GLIS3
9.212e-03	-4.69	POU2F1 (POU class 2 homeobox 1)	protein interactions	5451	168	3	19454	50	GPC5,SOX5,ARHGAP24
9.227e-03	-4.69	cervix	COSMIC cancer mutations	cervix	11793	42	16828	49	CDH20,FBXL7,PON2,CKB,PARD3B,LSAMP,DTNA,NPAS3,PREX2,COL5A3,SLC1A2,ERBB4,ITPR2,NRXN1,ZNRF3,ARHGAP24,NEBL,PITPNC1,SLC1A3,GLUL,GLIS3,SFXN5,ATP1A2,ATP13A4,CTNND2,HPSE2,SOX5,BMPR1B,PAMR1,NHSL1,ZBTB20,NTM,GPC5,QKI,SLC4A4,SPARCL1,RYR3,LRIG1,TNIK,RORA,CST3,GPM6A
9.442e-03	-4.66	NXPH3 (neurexophilin 3)	protein interactions	11248	57	2	19454	50	NRXN1,CTNNA2
9.513e-03	-4.66	SH2D3C (SH2 domain containing 3C)	protein interactions	10044	170	3	19454	50	CKB,PON2,ERBB4
9.565e-03	-4.65	export from cell	biological process	GO:0140352	485	5	18204	49	CAMK2G,ATP1A2,NRXN1,SLC4A4,PTGDS
9.613e-03	-4.64	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	21	SLC1A2,CST3
9.625e-03	-4.64	response to cocaine	biological process	GO:0042220	55	2	18204	49	SLC1A3,SLC1A2
9.634e-03	-4.64	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	49	16828	49	ATP13A4,CTNND2,ATP1A2,GLIS3,NHSL1,ZBTB20,SPARCL1,TNIK,GPM6A,RORA,FBXL7,CDH20,LSAMP,AQP4,DTNA,PREX2,NKAIN3,NRXN1,SLC1A2,COL5A3,GLUL,PITPNC1,HPSE2,SFXN5,BMPR1B,PAMR1,SOX5,WWOX,NTM,GPC5,QKI,SLC4A4,LRIG1,RYR3,CST3,PTGDS,CAMK2G,PON2,CLU,PARD3B,CKB,NPAS3,ITPR2,ERBB4,MSI2,ARHGAP24,ZNRF3,NEBL,SLC1A3
9.763e-03	-4.63	CILK1 (ciliogenesis associated kinase 1)	protein interactions	22858	58	2	19454	50	CAMK2G,MSI2
9.763e-03	-4.63	LRIG1 (leucine rich repeats and immunoglobulin like domains 1)	protein interactions	26018	58	2	19454	50	ERBB4,PON2
9.763e-03	-4.63	ZMAT5 (zinc finger matrin-type 5)	protein interactions	55954	58	2	19454	50	WWOX,QKI
9.814e-03	-4.62	establishment of localization	biological process	GO:0051234	3887	18	18204	49	GPM6A,QKI,PITPNC1,SLC1A3,PARD3B,NRXN1,SLC4A4,SLC1A2,AQP4,RYR3,ATP13A4,CAMK2G,ITPR2,ERBB4,ATP1A2,SFXN5,CLU,PTGDS
9.818e-03	-4.62	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	9	16828	49	NEBL,NTM,GPM6A,TNIK,RYR3,PAMR1,ATP13A4,HPSE2,CTNND2
9.818e-03	-4.62	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	9	16828	49	HPSE2,CTNND2,ATP13A4,RYR3,PAMR1,TNIK,NEBL,GPM6A,NTM
9.929e-03	-4.61	import across plasma membrane	biological process	GO:0098739	165	3	18204	49	SLC1A3,ATP1A2,SLC1A2
9.956e-03	-4.61	GABA shunt	BIOCYC pathways	HUMAN_GLUDEG-I-PWY	3	1	902	3	GLUL
9.964e-03	-4.61	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	49	RYR3,ITPR2
1.009e-02	-4.60	ADAM17 (ADAM metallopeptidase domain 17)	protein interactions	6868	59	2	19454	50	ERBB4,CAMK2G
1.009e-02	-4.60	HBA1 (hemoglobin subunit alpha 1)	protein interactions	3039	59	2	19454	50	ARHGAP24,CLU
1.012e-02	-4.59	tibia	COSMIC cancer mutations	tibia	836	7	16828	49	CTNND2,NKAIN3,PREX2,TNIK,GPM6A,QKI,LSAMP
1.013e-02	-4.59	DUSP14 (dual specificity phosphatase 14)	protein interactions	11072	174	3	19454	50	ERBB4,QKI,SPARCL1
1.013e-02	-4.59	NME2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	4831	174	3	19454	50	WWOX,RORA,ARHGAP24
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	CTNNA2,DTNA,CDH20
1.022e-02	-4.58	collagen type V trimer	cellular component	GO:0005588	4	1	19108	49	COL5A3
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	ZNF749 (zinc finger protein 749)	protein interactions	388567	4	1	19454	50	ARHGAP24
1.024e-02	-4.58	CALML4 (calmodulin like 4)	protein interactions	91860	4	1	19454	50	CAMK2G
1.024e-02	-4.58	ZNF879 (zinc finger protein 879)	protein interactions	345462	4	1	19454	50	ARHGAP24
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	ZNF615 (zinc finger protein 615)	protein interactions	284370	4	1	19454	50	ARHGAP24
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	MYH16 (myosin heavy chain 16 (pseudogene))	protein interactions	84176	4	1	19454	50	WWOX
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.026e-02	-4.58	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	27	16828	49	ZBTB20,GPC5,NTM,ATP1A2,CTNND2,HPSE2,ATP13A4,SOX5,PAMR1,BMPR1B,TNIK,RORA,SLC4A4,RYR3,LRIG1,PON2,CLU,CAMK2G,CKB,ZNRF3,ARHGAP24,PITPNC1,GLUL,PREX2,ERBB4,NRXN1,ITPR2
1.026e-02	-4.58	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	27	16828	49	TNIK,RORA,SLC4A4,RYR3,LRIG1,ZBTB20,NTM,GPC5,ATP1A2,ATP13A4,HPSE2,CTNND2,SOX5,PAMR1,BMPR1B,ZNRF3,ARHGAP24,PITPNC1,GLUL,PREX2,ERBB4,ITPR2,NRXN1,CLU,PON2,CAMK2G,CKB
1.030e-02	-4.58	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	42	GPM6A
1.030e-02	-4.58	VINCULIN_1	prosite domains	PS00663	3	1	12186	42	CTNNA2
1.030e-02	-4.58	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	42	GPM6A
1.031e-02	-4.57	visual behavior	biological process	GO:0007632	57	2	18204	49	SLC1A2,ATP1A2
1.031e-02	-4.57	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	49	ITPR2,RYR3
1.042e-02	-4.56	LRIG2 (leucine rich repeats and immunoglobulin like domains 2)	protein interactions	9860	60	2	19454	50	LRIG1,PON2
1.042e-02	-4.56	ITGA8 (integrin subunit alpha 8)	protein interactions	8516	60	2	19454	50	CLU,ZNRF3
1.054e-02	-4.55	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	156	3	16828	49	ARHGAP24,WWOX,PARD3B
1.057e-02	-4.55	citrate transmembrane transporter activity	molecular function	GO:0015137	4	1	18094	48	SFXN5
1.057e-02	-4.55	tricarboxylic acid transmembrane transporter activity	molecular function	GO:0015142	4	1	18094	48	SFXN5
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.072e-02	-4.54	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	49	BMPR1B
1.072e-02	-4.54	response to glycoside	biological process	GO:1903416	4	1	18204	49	ATP1A2
1.072e-02	-4.54	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	49	ATP1A2
1.072e-02	-4.54	negative regulation of male germ cell proliferation	biological process	GO:2000255	4	1	18204	49	PTGDS
1.072e-02	-4.54	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	49	CST3
1.072e-02	-4.54	negative regulation of germ cell proliferation	biological process	GO:1905937	4	1	18204	49	PTGDS
1.072e-02	-4.54	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	49	ATP1A2
1.072e-02	-4.54	cardiac muscle tissue regeneration	biological process	GO:0061026	4	1	18204	49	ERBB4
1.072e-02	-4.54	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	49	CLU
1.072e-02	-4.54	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	49	SOX5
1.074e-02	-4.53	Oxytocin signaling pathway	KEGG pathways	ko04921	152	3	7161	22	RYR3,ITPR2,CAMK2G
1.074e-02	-4.53	Oxytocin signaling pathway	KEGG pathways	hsa04921	152	3	7161	22	ITPR2,RYR3,CAMK2G
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	ATP-guanido_PTrfase_N	interpro domains	IPR022413	4	1	18521	50	CKB
1.076e-02	-4.53	ATP-guanido_PTrfase_N_sf	interpro domains	IPR036802	4	1	18521	50	CKB
1.076e-02	-4.53	Tyr_kinase_EGF/ERB/XmrK_rcpt	interpro domains	IPR016245	4	1	18521	50	ERBB4
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	Ca/CaM-dep_prot_kinase-assoc	interpro domains	IPR013543	4	1	18521	50	CAMK2G
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	ATP-guanido_PTrfase_AS	interpro domains	IPR022415	4	1	18521	50	CKB
1.076e-02	-4.53	ATP-guanido_PTrfase	interpro domains	IPR000749	4	1	18521	50	CKB
1.076e-02	-4.53	ATP-guanido_PTrfase_cat	interpro domains	IPR022414	4	1	18521	50	CKB
1.076e-02	-4.53	CABP2 (calcium binding protein 2)	protein interactions	51475	61	2	19454	50	CAMK2G,ITPR2
1.077e-02	-4.53	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	3	19454	50	LRIG1,WWOX,ERBB4
1.077e-02	-4.53	transport	biological process	GO:0006810	3615	17	18204	49	AQP4,RYR3,ATP13A4,CAMK2G,ITPR2,ATP1A2,ERBB4,CLU,SFXN5,PTGDS,GPM6A,QKI,PITPNC1,SLC1A3,NRXN1,SLC4A4,SLC1A2
1.087e-02	-4.52	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	32	SLC1A3,SLC1A2
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	NKAIN3,PREX2,SLC1A2,COL5A3,NRXN1,PITPNC1,GLUL,CDH20,FBXL7,AQP4,LSAMP,DTNA,SPARCL1,TNIK,RORA,GPM6A,ATP1A2,GLIS3,ATP13A4,CTNND2,NHSL1,ZBTB20,NPAS3,ERBB4,MSI2,ITPR2,ZNRF3,ARHGAP24,NEBL,SLC1A3,CLU,PON2,PTGDS,CAMK2G,CKB,PARD3B,SLC4A4,RYR3,LRIG1,CST3,SFXN5,HPSE2,SOX5,WWOX,PAMR1,BMPR1B,NTM,GPC5,QKI
1.101e-02	-4.51	protein localization to synapse	biological process	GO:0035418	59	2	18204	49	ERBB4,NRXN1
1.104e-02	-4.51	EZR (ezrin)	protein interactions	7430	526	5	19454	50	DTNA,WWOX,ARHGAP24,NEBL,TNIK
1.107e-02	-4.50	PLP	smart domains	SM00002	3	1	9717	36	GPM6A
1.119e-02	-4.49	CaMKII_AD	pfam domains	PF08332	4	1	17795	50	CAMK2G
1.119e-02	-4.49	P5-ATPase	pfam domains	PF12409	4	1	17795	50	ATP13A4
1.119e-02	-4.49	NKAIN	pfam domains	PF05640	4	1	17795	50	NKAIN3
1.119e-02	-4.49	ATP-gua_Ptrans	pfam domains	PF00217	4	1	17795	50	CKB
1.119e-02	-4.49	Nebulin	pfam domains	PF00880	4	1	17795	50	NEBL
1.119e-02	-4.49	NHS	pfam domains	PF15273	4	1	17795	50	NHSL1
1.119e-02	-4.49	ATP-gua_PtransN	pfam domains	PF02807	4	1	17795	50	CKB
1.126e-02	-4.49	monoatomic cation homeostasis	biological process	GO:0055080	505	5	18204	49	ATP1A2,SLC4A4,RYR3,SLC1A3,ATP13A4
1.137e-02	-4.48	protein homotetramerization	biological process	GO:0051289	60	2	18204	49	AQP4,RYR3
1.137e-02	-4.48	export across plasma membrane	biological process	GO:0140115	60	2	18204	49	SLC4A4,ATP1A2
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.144e-02	-4.47	RYANODINER	prints domains	PR00795	3	1	5227	20	RYR3
1.144e-02	-4.47	INSP3RECEPTR	prints domains	PR00779	3	1	5227	20	ITPR2
1.144e-02	-4.47	PARAOXONASE	prints domains	PR01785	3	1	5227	20	PON2
1.144e-02	-4.47	MYELINPLP	prints domains	PR00214	3	1	5227	20	GPM6A
1.144e-02	-4.47	RORNUCRECPTR	prints domains	PR01293	3	1	5227	20	RORA
1.144e-02	-4.47	PGNDSYNTHASE	prints domains	PR01254	3	1	5227	20	PTGDS
1.144e-02	-4.47	NAXD (NAD(P)HX dehydratase)	protein interactions	55739	63	2	19454	50	PON2,NEBL
1.144e-02	-4.47	NLGN2 (neuroligin 2)	protein interactions	57555	63	2	19454	50	CLU,NRXN1
1.144e-02	-4.47	INTS13 (integrator complex subunit 13)	protein interactions	55726	63	2	19454	50	TNIK,ARHGAP24
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.161e-02	-4.46	GSN (gelsolin)	protein interactions	2934	183	3	19454	50	TNIK,ARHGAP24,DTNA
1.179e-02	-4.44	COL1A2 (collagen type I alpha 2 chain)	protein interactions	1278	64	2	19454	50	ARHGAP24,COL5A3
1.190e-02	-4.43	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	15	16828	49	CLU,CTNND2,NHSL1,ZNRF3,TNIK,PITPNC1,SPARCL1,NKAIN3,PREX2,SLC4A4,ITPR2,LRIG1,ERBB4,COL5A3,RYR3
1.190e-02	-4.43	gallbladder	COSMIC cancer mutations	gallbladder	2821	15	16828	49	PITPNC1,ZNRF3,TNIK,RYR3,COL5A3,ERBB4,LRIG1,ITPR2,SLC4A4,NKAIN3,PREX2,SPARCL1,CLU,NHSL1,CTNND2
1.195e-02	-4.43	inorganic ion transmembrane transport	biological process	GO:0098660	715	6	18204	49	SLC4A4,ATP1A2,ITPR2,SLC1A3,RYR3,GPM6A
1.205e-02	-4.42	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	30	16828	49	ZBTB20,QKI,ATP1A2,GLIS3,CTNND2,ATP13A4,SOX5,PAMR1,TNIK,CST3,RORA,SLC4A4,SPARCL1,RYR3,LRIG1,PON2,CAMK2G,PTGDS,DTNA,PARD3B,SLC1A3,NEBL,GLUL,PREX2,NKAIN3,NPAS3,ERBB4,COL5A3,NRXN1,ITPR2
1.211e-02	-4.41	ATP:guanido phosphotransferase, N-terminal domain	gene3d domains	1.10.135.10	4	1	14470	44	CKB
1.211e-02	-4.41	regulation of carbohydrate catabolic process	biological process	GO:0043470	62	2	18204	49	ZBTB20,SLC4A4
1.212e-02	-4.41	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	12	16828	49	MSI2,ERBB4,ITPR2,PREX2,RORA,NEBL,GPM6A,ZNRF3,ARHGAP24,GPC5,AQP4,LSAMP
1.213e-02	-4.41	Heparan sulfate/heparin (HS-GAG) metabolism	REACTOME pathways	R-HSA-1638091	54	2	10285	32	HPSE2,GPC5
1.218e-02	-4.41	monoatomic ion homeostasis	biological process	GO:0050801	515	5	18204	49	SLC1A3,RYR3,ATP13A4,SLC4A4,ATP1A2
1.249e-02	-4.38	back	COSMIC cancer mutations	back	310	4	16828	49	ERBB4,ATP1A2,PREX2,TNIK
1.250e-02	-4.38	KATNA1 (katanin catalytic subunit A1)	protein interactions	11104	66	2	19454	50	ARHGAP24,CLU
1.250e-02	-4.38	ORM1 (orosomucoid 1)	protein interactions	5004	66	2	19454	50	PTGDS,CLU
1.250e-02	-4.38	PPM1F (protein phosphatase, Mg2+/Mn2+ dependent 1F)	protein interactions	9647	66	2	19454	50	ERBB4,WWOX
1.250e-02	-4.38	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	2	19454	50	CLU,SFXN5
1.254e-02	-4.38	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	19	16828	49	PARD3B,AQP4,CAMK2G,GLIS3,ATP1A2,FBXL7,CTNND2,NEBL,PITPNC1,GPM6A,TNIK,ZNRF3,SLC1A2,COL5A3,RYR3,ERBB4,SLC4A4,NPAS3,PREX2
1.258e-02	-4.38	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	19	16828	49	CAMK2G,PARD3B,AQP4,CTNND2,FBXL7,ATP1A2,GLIS3,ZNRF3,TNIK,GPM6A,PITPNC1,NEBL,PREX2,NPAS3,SLC4A4,ERBB4,RYR3,SLC1A2,COL5A3
1.262e-02	-4.37	bone-pelvis-chondrosarcoma	COSMIC cancer mutations	bone-pelvis-chondrosarcoma	311	4	16828	49	PARD3B,LSAMP,ERBB4,COL5A3
1.265e-02	-4.37	brain development	biological process	GO:0007420	724	6	18204	49	CKB,SLC1A2,CTNNA2,ERBB4,ATP1A2,RORA
1.268e-02	-4.37	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	20	16828	49	GPM6A,TNIK,ITPR2,LRIG1,RYR3,COL5A3,PREX2,SLC4A4,PARD3B,NTM,CKB,ZBTB20,PTGDS,NHSL1,SOX5,CTNND2,HPSE2,FBXL7,ATP13A4,CDH20
1.276e-02	-4.36	calcium- and calmodulin-dependent protein kinase complex	cellular component	GO:0005954	5	1	19108	49	CAMK2G
1.276e-02	-4.36	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	49	CLU
1.279e-02	-4.36	ZNF836 (zinc finger protein 836)	protein interactions	162962	5	1	19454	50	ARHGAP24
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	PTGER2 (prostaglandin E receptor 2)	protein interactions	5732	5	1	19454	50	PTGDS
1.279e-02	-4.36	Hk3 (hexokinase 3)	protein interactions	25060	5	1	19454	50	PTGDS
1.279e-02	-4.36	CAMK2N2 (calcium/calmodulin dependent protein kinase II inhibitor 2)	protein interactions	94032	5	1	19454	50	CAMK2G
1.279e-02	-4.36	NRG2 (neuregulin 2)	protein interactions	9542	5	1	19454	50	ERBB4
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	ARHGAP24
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	50	NRXN1
1.279e-02	-4.36	ZNF93 (zinc finger protein 93)	protein interactions	81931	5	1	19454	50	ARHGAP24
1.279e-02	-4.36	POU2F3 (POU class 2 homeobox 3)	protein interactions	25833	5	1	19454	50	ARHGAP24
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	ZNF571 (zinc finger protein 571)	protein interactions	51276	5	1	19454	50	ARHGAP24
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.279e-02	-4.36	ORF17 (ORF17)	protein interactions	4961478	5	1	19454	50	WWOX
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.281e-02	-4.36	cell population proliferation	biological process	GO:0008283	726	6	18204	49	SOX5,HPSE2,GLUL,ZNRF3,RORA,CLU
1.287e-02	-4.35	SHC3 (SHC adaptor protein 3)	protein interactions	53358	67	2	19454	50	ERBB4,WWOX
1.293e-02	-4.35	stem cell differentiation	biological process	GO:0048863	182	3	18204	49	ERBB4,MSI2,GPM6A
1.296e-02	-4.35	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	49	ZNRF3,WWOX,GPC5,CTNND2
1.312e-02	-4.33	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	3	18204	49	RORA,SLC4A4,ZBTB20
1.317e-02	-4.33	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	3	18094	48	SFXN5,SLC1A3,SLC1A2
1.320e-02	-4.33	neuroligin family protein binding	molecular function	GO:0097109	5	1	18094	48	NRXN1
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.325e-02	-4.32	apoptotic mitochondrial changes	biological process	GO:0008637	65	2	18204	49	ERBB4,CLU
1.326e-02	-4.32	creatine-phosphate biosynthesis	BIOCYC pathways	META_PWY-6158	4	1	902	3	CKB
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A3,SLC1A2
1.328e-02	-4.32	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	10	18204	49	BMPR1B,ZBTB20,SOX5,NRXN1,ERBB4,ATP1A2,SFXN5,RORA,CLU,QKI
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.336e-02	-4.32	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	3	18094	48	SFXN5,SLC1A3,SLC1A2
1.339e-02	-4.31	citrate transport	biological process	GO:0015746	5	1	18204	49	SFXN5
1.339e-02	-4.31	otolith morphogenesis	biological process	GO:0032474	5	1	18204	49	LRIG1
1.339e-02	-4.31	ERBB2-ERBB4 signaling pathway	biological process	GO:0038135	5	1	18204	49	ERBB4
1.339e-02	-4.31	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	49	CLU
1.339e-02	-4.31	tricarboxylic acid transport	biological process	GO:0006842	5	1	18204	49	SFXN5
1.339e-02	-4.31	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	49	NRXN1
1.339e-02	-4.31	phosphocreatine metabolic process	biological process	GO:0006603	5	1	18204	49	CKB
1.339e-02	-4.31	phosphagen metabolic process	biological process	GO:0006599	5	1	18204	49	CKB
1.339e-02	-4.31	phosphocreatine biosynthetic process	biological process	GO:0046314	5	1	18204	49	CKB
1.339e-02	-4.31	amygdala development	biological process	GO:0021764	5	1	18204	49	ATP1A2
1.339e-02	-4.31	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	49	CLU
1.339e-02	-4.31	phosphagen biosynthetic process	biological process	GO:0042396	5	1	18204	49	CKB
1.339e-02	-4.31	negative regulation of Rac protein signal transduction	biological process	GO:0035021	5	1	18204	49	ARHGAP24
1.339e-02	-4.31	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	49	BMPR1B
1.343e-02	-4.31	BBP-like	interpro domains	IPR045071	5	1	18521	50	QKI
1.343e-02	-4.31	Mtc	interpro domains	IPR004686	5	1	18521	50	SFXN5
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.357e-02	-4.30	CNPY3 (canopy FGF signaling regulator 3)	protein interactions	10695	194	3	19454	50	CAMK2G,LRIG1,ITPR2
1.361e-02	-4.30	PABPC3 (poly(A) binding protein cytoplasmic 3)	protein interactions	5042	69	2	19454	50	ARHGAP24,WWOX
1.364e-02	-4.29	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	49	SLC1A3,SLC1A2
1.372e-02	-4.29	NEBULIN	prosite domains	PS51216	4	1	12186	42	NEBL
1.372e-02	-4.29	PHOSPHAGEN_KINASE	prosite domains	PS00112	4	1	12186	42	CKB
1.372e-02	-4.29	PHOSPHAGEN_KINASE_N	prosite domains	PS51509	4	1	12186	42	CKB
1.372e-02	-4.29	PHOSPHAGEN_KINASE_C	prosite domains	PS51510	4	1	12186	42	CKB
1.375e-02	-4.29	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	38	16828	49	ZBTB20,GPC5,NTM,SFXN5,GLIS3,ATP1A2,HPSE2,CTNND2,ATP13A4,SOX5,PAMR1,BMPR1B,TNIK,RORA,GPM6A,SLC4A4,RYR3,LRIG1,PON2,DTNA,PARD3B,LSAMP,CDH20,FBXL7,ZNRF3,ARHGAP24,SLC1A3,PITPNC1,NEBL,GLUL,PREX2,NKAIN3,NPAS3,ERBB4,SLC1A2,COL5A3,NRXN1,ITPR2
1.375e-02	-4.29	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	38	16828	49	ARHGAP24,ZNRF3,GLUL,SLC1A3,PITPNC1,NEBL,NKAIN3,PREX2,NPAS3,NRXN1,ITPR2,ERBB4,COL5A3,SLC1A2,PON2,DTNA,LSAMP,PARD3B,FBXL7,CDH20,TNIK,GPM6A,RORA,SLC4A4,LRIG1,RYR3,GPC5,NTM,ZBTB20,HPSE2,CTNND2,ATP13A4,SFXN5,GLIS3,ATP1A2,PAMR1,BMPR1B,SOX5
1.397e-02	-4.27	IP_trans	pfam domains	PF02121	5	1	17795	50	PITPNC1
1.397e-02	-4.27	FOLN	pfam domains	PF09289	5	1	17795	50	SPARCL1
1.397e-02	-4.27	SFXNs	pfam domains	PF03820	5	1	17795	50	SFXN5
1.397e-02	-4.27	Vinculin	pfam domains	PF01044	5	1	17795	50	CTNNA2
1.399e-02	-4.27	MTMR9 (myotubularin related protein 9)	protein interactions	66036	70	2	19454	50	CLU,ERBB4
1.399e-02	-4.27	PCDH20 (protocadherin 20)	protein interactions	64881	70	2	19454	50	CTNNA2,PON2
1.404e-02	-4.27	collagen binding	molecular function	GO:0005518	68	2	18094	48	COL5A3,SPARCL1
1.412e-02	-4.26	YES1 (YES proto-oncogene 1, Src family tyrosine kinase)	protein interactions	7525	364	4	19454	50	CAMK2G,GLUL,ERBB4,MSI2
1.437e-02	-4.24	Arachidonic acid metabolism	REACTOME pathways	R-HSA-2142753	59	2	10285	32	PTGDS,PON2
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	GPM6A,TNIK
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.457e-02	-4.23	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	8	16828	49	GPC5,QKI,ATP13A4,CDH20,ERBB4,SOX5,SLC1A2,RYR3
1.474e-02	-4.22	NEBU	smart domains	SM00227	4	1	9717	36	NEBL
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	BMPR1B,PARD3B
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	GPM6A,TNIK
1.480e-02	-4.21	EGF	pfam domains	PF00008	66	2	17795	50	NRXN1,PAMR1
1.493e-02	-4.20	presynapse	cellular component	GO:0098793	569	5	19108	49	GPM6A,TNIK,NRXN1,SLC1A2,ERBB4
1.511e-02	-4.19	-	gene3d domains	6.10.140.620	5	1	14470	44	CAMK2G
1.520e-02	-4.19	ORF3a (ORF3a protein)	protein interactions	43740569	789	6	19454	50	ZNRF3,CKB,CLU,PARD3B,BMPR1B,SLC4A4
1.522e-02	-4.19	ALPHACATENIN	prints domains	PR00805	4	1	5227	20	CTNNA2
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	TAT (tyrosine aminotransferase)	protein interactions	6898	6	1	19454	50	GLUL
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.532e-02	-4.18	RSPO3 (R-spondin 3)	protein interactions	84870	6	1	19454	50	ZNRF3
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	DAZ4 (deleted in azoospermia 4)	protein interactions	57135	6	1	19454	50	QKI
1.532e-02	-4.18	PBP2 (Pbp2p)	protein interactions	852533	6	1	19454	50	QKI
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	NRG4 (neuregulin 4)	protein interactions	145957	6	1	19454	50	ERBB4
1.532e-02	-4.18	ZNF311 (zinc finger protein 311)	protein interactions	282890	6	1	19454	50	ARHGAP24
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	CIBAR2 (CBY1 interacting BAR domain containing 2)	protein interactions	339145	6	1	19454	50	CAMK2G
1.532e-02	-4.18	CYP39A1 (cytochrome P450 family 39 subfamily A member 1)	protein interactions	51302	6	1	19454	50	GLUL
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	50	NRXN1
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	SMR3A (submaxillary gland androgen regulated protein 3A)	protein interactions	26952	6	1	19454	50	WWOX
1.533e-02	-4.18	protein homooligomerization	biological process	GO:0051260	194	3	18204	49	SLC1A2,RYR3,AQP4
1.535e-02	-4.18	cell-cell adhesion	biological process	GO:0098609	546	5	18204	49	CTNNA2,CDH20,NRXN1,CTNND2,SPARCL1
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	DTNA,PARD3B,NRXN1
1.554e-02	-4.16	CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1)	protein interactions	781	74	2	19454	50	GPM6A,PON2
1.554e-02	-4.16	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	2	19454	50	ERBB4,MSI2
1.581e-02	-4.15	arylesterase activity	molecular function	GO:0004064	6	1	18094	48	PON2
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.581e-02	-4.15	creatine kinase activity	molecular function	GO:0004111	6	1	18094	48	CKB
1.600e-02	-4.13	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	9	16828	49	ATP13A4,HPSE2,CTNND2,ATP1A2,ITPR2,RYR3,ERBB4,PARD3B,CKB
1.600e-02	-4.13	PDGFRA (platelet derived growth factor receptor alpha)	protein interactions	5156	378	4	19454	50	LRIG1,CLU,DTNA,WWOX
1.604e-02	-4.13	imitative learning	biological process	GO:0098596	6	1	18204	49	NRXN1
1.604e-02	-4.13	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	49	SLC1A3
1.604e-02	-4.13	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	49	CLU
1.604e-02	-4.13	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	1	18204	49	NRXN1
1.604e-02	-4.13	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	49	SOX5
1.604e-02	-4.13	intracellular water homeostasis	biological process	GO:0009992	6	1	18204	49	AQP4
1.604e-02	-4.13	vocal learning	biological process	GO:0042297	6	1	18204	49	NRXN1
1.604e-02	-4.13	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	49	CST3
1.604e-02	-4.13	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	49	ERBB4
1.604e-02	-4.13	fused antrum stage	biological process	GO:0048165	6	1	18204	49	BMPR1B
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	GF_recep_IV	interpro domains	IPR032778	6	1	18521	50	ERBB4
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	1	18521	50	NRXN1
1.609e-02	-4.13	regulation of ATP metabolic process	biological process	GO:1903578	72	2	18204	49	SLC4A4,ZBTB20
1.613e-02	-4.13	MAGEA9 (MAGE family member A9)	protein interactions	4108	207	3	19454	50	CAMK2G,ITPR2,NHSL1
1.635e-02	-4.11	PGM3 (phosphoglucomutase 3)	protein interactions	5238	76	2	19454	50	ARHGAP24,GLUL
1.635e-02	-4.11	MIR200A (microRNA 200a)	protein interactions	406983	76	2	19454	50	QKI,MSI2
1.652e-02	-4.10	regulation of cartilage development	biological process	GO:0061035	73	2	18204	49	BMPR1B,SOX5
1.674e-02	-4.09	EF-hand_2	pfam domains	PF09068	6	1	17795	50	DTNA
1.674e-02	-4.09	Glypican	pfam domains	PF01153	6	1	17795	50	GPC5
1.674e-02	-4.09	GF_recep_IV	pfam domains	PF14843	6	1	17795	50	ERBB4
1.674e-02	-4.09	Syndecan	pfam domains	PF01034	6	1	17795	50	NRXN1
1.674e-02	-4.09	EF-hand_3	pfam domains	PF09069	6	1	17795	50	DTNA
1.701e-02	-4.07	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	9	16828	49	CTNND2,HPSE2,ATP13A4,ATP1A2,ITPR2,ERBB4,RYR3,PARD3B,CKB
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP13A4,ATP1A2
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.710e-02	-4.07	head development	biological process	GO:0060322	774	6	18204	49	ERBB4,ATP1A2,RORA,SLC1A2,CTNNA2,CKB
1.717e-02	-4.06	MIR34C (microRNA 34c)	protein interactions	407042	78	2	19454	50	QKI,MSI2
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	MSI2,SOX5
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.738e-02	-4.05	amino acid biosynthetic process	biological process	GO:0008652	75	2	18204	49	GLUL,SLC1A3
1.751e-02	-4.05	face	COSMIC cancer mutations	face	2139	12	16828	49	LSAMP,AQP4,GPC5,ARHGAP24,ZNRF3,GPM6A,NEBL,RORA,PREX2,ITPR2,MSI2,ERBB4
1.754e-02	-4.04	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	21	ATP1A2,SLC1A3
1.759e-02	-4.04	NUCB2 (nucleobindin 2)	protein interactions	4925	79	2	19454	50	CLU,GLUL
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	TNIK,NHSL1,ERBB4
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	22	ITPR2,CAMK2G
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	22	CAMK2G,ITPR2
1.768e-02	-4.04	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	7	16828	49	ATP1A2,PREX2,ERBB4,ITPR2,BMPR1B,TNIK,CAMK2G
1.774e-02	-4.03	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	49	ITPR2,GPM6A,RYR3
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	CYYR1 (cysteine and tyrosine rich 1)	protein interactions	116159	7	1	19454	50	WWOX
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Pum2 (pumilio RNA-binding family member 2)	protein interactions	80913	7	1	19454	50	QKI
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	ZNF701 (zinc finger protein 701)	protein interactions	55762	7	1	19454	50	ARHGAP24
1.786e-02	-4.03	ZNF501 (zinc finger protein 501)	protein interactions	115560	7	1	19454	50	ARHGAP24
1.801e-02	-4.02	PIAS3 (protein inhibitor of activated STAT 3)	protein interactions	10401	80	2	19454	50	GLUL,ERBB4
1.804e-02	-4.01	CAMK2G (calcium/calmodulin dependent protein kinase II gamma)	protein interactions	818	216	3	19454	50	PON2,ITPR2,CAMK2G
1.827e-02	-4.00	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	2	18204	49	NRXN1,ATP1A2
1.843e-02	-3.99	phosphotransferase activity, nitrogenous group as acceptor	molecular function	GO:0016775	7	1	18094	48	CKB
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.843e-02	-3.99	calcium-dependent protein serine/threonine phosphatase activity	molecular function	GO:0004723	7	1	18094	48	CAMK2G
1.865e-02	-3.98	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	4	18521	50	ERBB4,TNIK,BMPR1B,CAMK2G
1.869e-02	-3.98	regulation of 3'-UTR-mediated mRNA stabilization	biological process	GO:1905868	7	1	18204	49	QKI
1.869e-02	-3.98	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	49	RYR3
1.869e-02	-3.98	negative regulation of ruffle assembly	biological process	GO:1900028	7	1	18204	49	ARHGAP24
1.869e-02	-3.98	observational learning	biological process	GO:0098597	7	1	18204	49	NRXN1
1.869e-02	-3.98	regulation of male germ cell proliferation	biological process	GO:2000254	7	1	18204	49	PTGDS
1.869e-02	-3.98	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	49	CLU
1.869e-02	-3.98	negative regulation of non-canonical Wnt signaling pathway	biological process	GO:2000051	7	1	18204	49	ZNRF3
1.869e-02	-3.98	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	49	CTNNA2
1.872e-02	-3.98	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	2	18204	49	ZBTB20,SLC4A4
1.872e-02	-3.98	dicarboxylic acid transport	biological process	GO:0006835	78	2	18204	49	SLC1A2,SLC1A3
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	Rcpt_L-dom	interpro domains	IPR000494	7	1	18521	50	ERBB4
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Rcpt_L-dom_sf	interpro domains	IPR036941	7	1	18521	50	ERBB4
1.875e-02	-3.98	Aquaporin_transptr	interpro domains	IPR034294	7	1	18521	50	AQP4
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.875e-02	-3.98	Furin-like_Cys-rich_dom	interpro domains	IPR006211	7	1	18521	50	ERBB4
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP13A4,ATP1A2
1.886e-02	-3.97	HYAL2 (hyaluronidase 2)	protein interactions	8692	82	2	19454	50	WWOX,PON2
1.897e-02	-3.96	human chr12p11.23	chromosome location	human chr12p11.23	10	1	26134	50	ITPR2
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.899e-02	-3.96	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	20	SLC4A4
1.899e-02	-3.96	PITRANSFER	prints domains	PR00391	5	1	5227	20	PITPNC1
1.911e-02	-3.96	synaptic membrane	cellular component	GO:0097060	400	4	19108	49	NRXN1,SLC1A2,ERBB4,GPM6A
1.929e-02	-3.95	localization	biological process	GO:0051179	4474	19	18204	49	PTGDS,ERBB4,ATP1A2,SFXN5,CLU,ITPR2,ATP13A4,CAMK2G,RYR3,AQP4,TNIK,SLC1A2,NRXN1,SLC4A4,PARD3B,SLC1A3,QKI,PITPNC1,GPM6A
1.930e-02	-3.95	SYT1 (synaptotagmin 1)	protein interactions	6857	83	2	19454	50	GPM6A,NRXN1
1.951e-02	-3.94	Furin-like	pfam domains	PF00757	7	1	17795	50	ERBB4
1.951e-02	-3.94	TGF_beta_GS	pfam domains	PF08515	7	1	17795	50	BMPR1B
1.951e-02	-3.94	Recep_L_domain	pfam domains	PF01030	7	1	17795	50	ERBB4
1.951e-02	-3.94	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	50	SPARCL1
1.954e-02	-3.94	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	48	BMPR1B,ERBB4
1.962e-02	-3.93	KIF2A (kinesin family member 2A)	protein interactions	3796	223	3	19454	50	ARHGAP24,WWOX,GPM6A
1.974e-02	-3.93	ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)	protein interactions	7903	84	2	19454	50	PON2,LRIG1
2.009e-02	-3.91	adult locomotory behavior	biological process	GO:0008344	81	2	18204	49	PREX2,ATP1A2
2.018e-02	-3.90	CCND3 (cyclin D3)	protein interactions	896	85	2	19454	50	CLU,QKI
2.020e-02	-3.90	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	8	19454	50	LSAMP,GLIS3,QKI,MSI2,ITPR2,CKB,CLU,SOX5
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.034e-02	-3.90	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	49	CLU
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	PTGER1 (prostaglandin E receptor 1)	protein interactions	5731	8	1	19454	50	PTGDS
2.038e-02	-3.89	DEPP1 (DEPP autophagy regulator 1)	protein interactions	11067	8	1	19454	50	QKI
2.038e-02	-3.89	ZNF568 (zinc finger protein 568)	protein interactions	374900	8	1	19454	50	ARHGAP24
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.038e-02	-3.89	ZNF236 (zinc finger protein 236)	protein interactions	7776	8	1	19454	50	ARHGAP24
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.038e-02	-3.89	CATSPERE (catsper channel auxiliary subunit epsilon)	protein interactions	257044	8	1	19454	50	WWOX
2.038e-02	-3.89	ZNF28 (zinc finger protein 28)	protein interactions	7576	8	1	19454	50	ARHGAP24
2.051e-02	-3.89	GLYPICAN	prosite domains	PS01207	6	1	12186	42	GPC5
2.059e-02	-3.88	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	21	RYR3,ITPR2,CAMK2G
2.079e-02	-3.87	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	6	16828	49	SLC1A3,NEBL,DTNA,CTNND2,SOX5,ITPR2
2.084e-02	-3.87	dendrite	cellular component	GO:0030425	620	5	19108	49	CLU,GPM6A,CTNND2,BMPR1B,ATP1A2
2.090e-02	-3.87	PDIA3 (protein disulfide isomerase family A member 3)	protein interactions	2923	410	4	19454	50	WWOX,CKB,CLU,DTNA
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.108e-02	-3.86	MIR141 (microRNA 141)	protein interactions	406933	87	2	19454	50	QKI,MSI2
2.110e-02	-3.86	Receptor L-domain	gene3d domains	3.80.20.20	7	1	14470	44	ERBB4
2.110e-02	-3.86	dendritic tree	cellular component	GO:0097447	622	5	19108	49	ATP1A2,BMPR1B,CTNND2,GPM6A,CLU
2.111e-02	-3.86	anion binding	molecular function	GO:0043168	2412	12	18094	48	BMPR1B,PITPNC1,PTGDS,ATP13A4,GLUL,ERBB4,CAMK2G,TNIK,CKB,ATP1A2,ITPR2,SLC1A3
2.120e-02	-3.85	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	25	16828	49	ERBB4,COL5A3,NRXN1,ITPR2,PREX2,SLC1A3,NEBL,CDH20,CKB,DTNA,PARD3B,CLU,PON2,CAMK2G,LRIG1,SLC4A4,SPARCL1,GPM6A,ATP1A2,SFXN5,GLIS3,HPSE2,ATP13A4,ZBTB20,GPC5
2.125e-02	-3.85	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	44	ATP1A2,ATP13A4
2.125e-02	-3.85	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	12	16828	49	DTNA,PARD3B,CAMK2G,BMPR1B,WWOX,SOX5,ATP1A2,ARHGAP24,TNIK,ERBB4,PREX2,SLC4A4
2.127e-02	-3.85	ConA-like_dom_sf	interpro domains	IPR013320	219	3	18521	50	RYR3,COL5A3,NRXN1
2.129e-02	-3.85	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	25	16828	49	LRIG1,SLC4A4,SPARCL1,GPM6A,GLIS3,ATP1A2,SFXN5,HPSE2,ATP13A4,ZBTB20,GPC5,ERBB4,COL5A3,NRXN1,ITPR2,PREX2,SLC1A3,NEBL,CDH20,CKB,DTNA,PARD3B,PON2,CLU,CAMK2G
2.129e-02	-3.85	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	2	7161	22	ITPR2,ATP1A2
2.129e-02	-3.85	Thyroid hormone synthesis	KEGG pathways	ko04918	74	2	7161	22	ITPR2,ATP1A2
2.132e-02	-3.85	Creatine pathway	KEGG pathways	M00047	7	1	7161	22	CKB
2.132e-02	-3.85	Creatine pathway	KEGG pathways	hsa_M00047	7	1	7161	22	CKB
2.134e-02	-3.85	regulation of germ cell proliferation	biological process	GO:1905936	8	1	18204	49	PTGDS
2.134e-02	-3.85	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	49	CTNNA2
2.134e-02	-3.85	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	49	RORA
2.134e-02	-3.85	glutamate catabolic process	biological process	GO:0006538	8	1	18204	49	GLUL
2.134e-02	-3.85	protein import	biological process	GO:0017038	8	1	18204	49	CLU
2.134e-02	-3.85	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	49	ATP1A2
2.134e-02	-3.85	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	49	SLC1A3
2.134e-02	-3.85	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	49	RORA
2.134e-02	-3.85	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	49	ERBB4
2.134e-02	-3.85	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	49	RORA
2.134e-02	-3.85	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	49	SLC1A3,NRXN1,ATP1A2
2.151e-02	-3.84	L-amino acid transport	biological process	GO:0015807	84	2	18204	49	SLC1A2,SLC1A3
2.151e-02	-3.84	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	49	ATP1A2,NKAIN3
2.151e-02	-3.84	stem cell development	biological process	GO:0048864	84	2	18204	49	MSI2,ERBB4
2.151e-02	-3.84	SLC15A3 (solute carrier family 15 member 3)	protein interactions	51296	231	3	19454	50	PON2,ITPR2,CKB
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	BMPR1B,TNIK
2.175e-02	-3.83	SEC23A (SEC23 homolog A, COPII coat complex component)	protein interactions	10484	232	3	19454	50	WWOX,DTNA,ARHGAP24
2.186e-02	-3.82	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	49	ERBB4,PARD3B,ITPR2,PREX2,SLC4A4
2.199e-02	-3.82	chondrocyte differentiation	biological process	GO:0002062	85	2	18204	49	BMPR1B,SOX5
2.200e-02	-3.82	TNS2 (tensin 2)	protein interactions	23371	233	3	19454	50	ERBB4,DTNA,GLUL
2.201e-02	-3.82	organic anion transport	biological process	GO:0015711	398	4	18204	49	SLC1A2,SLC4A4,SFXN5,SLC1A3
2.232e-02	-3.80	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	5	16828	49	SLC4A4,FBXL7,CTNND2,ERBB4,RYR3
2.246e-02	-3.80	TXNDC11 (thioredoxin domain containing 11)	protein interactions	51061	90	2	19454	50	CLU,WWOX
2.246e-02	-3.80	MED25 (mediator complex subunit 25)	protein interactions	81857	90	2	19454	50	WWOX,QKI
2.246e-02	-3.80	FGFR1OP2 (FGFR1 oncogene partner 2)	protein interactions	26127	90	2	19454	50	TNIK,CAMK2G
2.247e-02	-3.80	protein localization to cell junction	biological process	GO:1902414	86	2	18204	49	NRXN1,ERBB4
2.262e-02	-3.79	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	5	16828	49	RYR3,ERBB4,SLC4A4,FBXL7,CTNND2
2.267e-02	-3.79	PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha)	protein interactions	5518	632	5	19454	50	NHSL1,ARHGAP24,CKB,CTNNA2,CAMK2G
2.272e-02	-3.78	human chr6q26	chromosome location	human chr6q26	12	1	26134	50	QKI
2.274e-02	-3.78	CTSL (cathepsin L)	protein interactions	1514	236	3	19454	50	CST3,PON2,CLU
2.275e-02	-3.78	ACTIVIN2R	prints domains	PR00653	6	1	5227	20	BMPR1B
2.285e-02	-3.78	platelet dense tubular network membrane	cellular component	GO:0031095	9	1	19108	49	ITPR2
2.285e-02	-3.78	astrocyte end-foot	cellular component	GO:0097450	9	1	19108	49	AQP4
2.290e-02	-3.78	MUC4 (mucin 4, cell surface associated)	protein interactions	4585	9	1	19454	50	ERBB4
2.290e-02	-3.78	ZNF766 (zinc finger protein 766)	protein interactions	90321	9	1	19454	50	ARHGAP24
2.290e-02	-3.78	CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1)	protein interactions	55450	9	1	19454	50	CAMK2G
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	ARHGAP24
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	Ywhag (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide)	protein interactions	22628	9	1	19454	50	QKI
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	NTM,GPM6A
2.306e-02	-3.77	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-chiasm-glioma-astrocytoma_Grade_I	8	1	16828	49	QKI
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.309e-02	-3.77	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	5	16828	49	CKB,ERBB4,RYR3,TNIK,CAMK2G
2.313e-02	-3.77	C20 prostanoid biosynthesis	BIOCYC pathways	HUMAN_PWY66-374	7	1	902	3	PTGDS
2.313e-02	-3.77	C20 prostanoid biosynthesis	BIOCYC pathways	META_PWY66-374	7	1	902	3	PTGDS
2.320e-02	-3.76	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	3	5310	21	RYR3,ITPR2,CAMK2G
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	CLU,GLUL,SPARCL1
2.325e-02	-3.76	forearm	COSMIC cancer mutations	forearm	81	2	16828	49	ERBB4,PREX2
2.331e-02	-3.76	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	48	CST3,CLU
2.339e-02	-3.76	RLN1 (relaxin 1)	protein interactions	6013	92	2	19454	50	PON2,LRIG1
2.341e-02	-3.75	skeletal system morphogenesis	biological process	GO:0048705	228	3	18204	49	SOX5,BMPR1B,WWOX
2.381e-02	-3.74	collagen-containing extracellular matrix	cellular component	GO:0062023	428	4	19108	49	CLU,COL5A3,SPARCL1,GPC5
2.387e-02	-3.74	TEX11 (testis expressed 11)	protein interactions	56159	93	2	19454	50	QKI,SOX5
2.387e-02	-3.74	DMRTB1 (DMRT like family B with proline rich C-terminal 1)	protein interactions	63948	93	2	19454	50	QKI,MSI2
2.387e-02	-3.74	ODR4 (odr-4 GPCR localization factor homolog)	protein interactions	54953	93	2	19454	50	LRIG1,GPM6A
2.387e-02	-3.74	FKBP15 (FKBP prolyl isomerase family member 15)	protein interactions	23307	93	2	19454	50	TNIK,WWOX
2.387e-02	-3.74	MIR19B2 (microRNA 19b-2)	protein interactions	406981	93	2	19454	50	MSI2,QKI
2.388e-02	-3.73	GS	prosite domains	PS51256	7	1	12186	42	BMPR1B
2.397e-02	-3.73	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	49	CTNNA2
2.397e-02	-3.73	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	49	ATP1A2
2.397e-02	-3.73	macrophage proliferation	biological process	GO:0061517	9	1	18204	49	CLU
2.397e-02	-3.73	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	49	CTNNA2
2.397e-02	-3.73	regulation of protein localization to nucleolus	biological process	GO:1904749	9	1	18204	49	GLUL
2.397e-02	-3.73	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	49	RYR3
2.397e-02	-3.73	cyclooxygenase pathway	biological process	GO:0019371	9	1	18204	49	PTGDS
2.397e-02	-3.73	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	49	ATP13A4
2.397e-02	-3.73	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	49	NRXN1
2.397e-02	-3.73	microglial cell proliferation	biological process	GO:0061518	9	1	18204	49	CLU
2.401e-02	-3.73	-	gene3d domains	2.80.10.50	79	2	14470	44	RYR3,ITPR2
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.404e-02	-3.73	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	50	CST3
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.408e-02	-3.73	ion binding	molecular function	GO:0043167	6007	23	18094	48	SLC1A3,ZNRF3,ATP1A2,GLIS3,GLUL,NRXN1,RORA,BMPR1B,PITPNC1,ITPR2,SLC1A2,SPARCL1,DTNA,TNIK,CKB,PAMR1,RYR3,CAMK2G,ERBB4,PTGDS,ATP13A4,ZBTB20,PON2
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CTNND2,CLU
2.438e-02	-3.71	postsynapse	cellular component	GO:0098794	646	5	19108	49	ERBB4,CTNND2,GPM6A,TNIK,ATP1A2
2.446e-02	-3.71	regulation of purine nucleotide metabolic process	biological process	GO:1900542	90	2	18204	49	ZBTB20,SLC4A4
2.451e-02	-3.71	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	36	16828	49	ATP13A4,HPSE2,CTNND2,ATP1A2,PAMR1,BMPR1B,SOX5,NTM,QKI,GPC5,SPARCL1,SLC4A4,LRIG1,RYR3,TNIK,GPM6A,RORA,CST3,FBXL7,CDH20,CAMK2G,CLU,PARD3B,DTNA,NPAS3,PREX2,NKAIN3,ITPR2,NRXN1,COL5A3,MSI2,ERBB4,ARHGAP24,ZNRF3,NEBL,PITPNC1
2.459e-02	-3.71	human chr5p15.1	chromosome location	human chr5p15.1	13	1	26134	50	FBXL7
2.463e-02	-3.70	Downregulation of ERBB4 signaling	REACTOME pathways	R-HSA-1253288	8	1	10285	32	ERBB4
2.463e-02	-3.70	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	32	GPC5
2.468e-02	-3.70	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	6	16828	49	ERBB4,SOX5,BMPR1B,TNIK,CTNND2,CAMK2G
2.468e-02	-3.70	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	6	16828	49	CTNND2,CAMK2G,TNIK,BMPR1B,ERBB4,SOX5
2.475e-02	-3.70	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	36	16828	49	GPC5,QKI,NTM,ATP1A2,CTNND2,HPSE2,ATP13A4,SOX5,PAMR1,BMPR1B,TNIK,CST3,RORA,GPM6A,SLC4A4,SPARCL1,RYR3,LRIG1,CLU,CAMK2G,DTNA,PARD3B,CDH20,FBXL7,ZNRF3,ARHGAP24,PITPNC1,NEBL,NKAIN3,PREX2,NPAS3,MSI2,ERBB4,COL5A3,NRXN1,ITPR2
2.476e-02	-3.70	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	21	SLC1A3,AQP4,RORA
2.483e-02	-3.70	H2BC13 (H2B clustered histone 13)	protein interactions	8340	95	2	19454	50	ARHGAP24,GPM6A
2.483e-02	-3.70	STRIP1 (striatin interacting protein 1)	protein interactions	85369	95	2	19454	50	TNIK,CAMK2G
2.483e-02	-3.70	DDX3Y (DEAD-box helicase 3 Y-linked)	protein interactions	8653	95	2	19454	50	WWOX,ARHGAP24
2.484e-02	-3.70	vesicle	cellular component	GO:0031982	4141	17	19108	49	SLC4A4,CST3,SLC1A2,ATP1A2,NRXN1,SLC1A3,GLUL,TNIK,NEBL,CKB,PTGDS,CLU,ATP13A4,GPM6A,AQP4,CAMK2G,ITPR2
2.491e-02	-3.69	behavior	biological process	GO:0007610	619	5	18204	49	NRXN1,ATP1A2,PREX2,SLC1A2,SLC1A3
2.496e-02	-3.69	regulation of nucleotide metabolic process	biological process	GO:0006140	91	2	18204	49	SLC4A4,ZBTB20
2.501e-02	-3.69	Band_3_cyto	pfam domains	PF07565	9	1	17795	50	SLC4A4
2.501e-02	-3.69	Activin_recp	pfam domains	PF01064	9	1	17795	50	BMPR1B
2.504e-02	-3.69	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	CKB,ERBB4,CAMK2G,TNIK
2.504e-02	-3.69	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	4	16828	49	ERBB4,CKB,TNIK,CAMK2G
2.504e-02	-3.69	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	CAMK2G,TNIK,ERBB4,CKB
2.504e-02	-3.69	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	TNIK,CAMK2G,ERBB4,CKB
2.504e-02	-3.69	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	4	16828	49	TNIK,CAMK2G,ERBB4,CKB
2.519e-02	-3.68	chemical synaptic transmission	biological process	GO:0007268	415	4	18204	49	SLC1A3,SLC1A2,DTNA,NRXN1
2.519e-02	-3.68	anterograde trans-synaptic signaling	biological process	GO:0098916	415	4	18204	49	SLC1A3,NRXN1,SLC1A2,DTNA
2.532e-02	-3.68	DUSP19 (dual specificity phosphatase 19)	protein interactions	142679	96	2	19454	50	CKB,ERBB4
2.532e-02	-3.68	PDIA5 (protein disulfide isomerase family A member 5)	protein interactions	10954	96	2	19454	50	ARHGAP24,NTM
2.532e-02	-3.68	SOCS2 (suppressor of cytokine signaling 2)	protein interactions	8835	96	2	19454	50	ERBB4,GLUL
2.534e-02	-3.68	g-Secretase Mediated ErbB4 Signalling Pathway	SMPDB pathways	SMP0089975	7	1	1369	5	ERBB4
2.537e-02	-3.67	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	10	19454	50	DTNA,CKB,ARHGAP24,PARD3B,BMPR1B,WWOX,MSI2,QKI,ZBTB20,PON2
2.539e-02	-3.67	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	4	10285	32	LRIG1,ERBB4,CAMK2G,ITPR2
2.541e-02	-3.67	PTPRT (protein tyrosine phosphatase receptor type T)	protein interactions	11122	10	1	19454	50	ERBB4
2.541e-02	-3.67	EREG (epiregulin)	protein interactions	2069	10	1	19454	50	ERBB4
2.541e-02	-3.67	Mrpl13 (mitochondrial ribosomal protein L13)	protein interactions	68537	10	1	19454	50	QKI
2.541e-02	-3.67	Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1)	protein interactions	15519	10	1	19454	50	QKI
2.541e-02	-3.67	BANK1 (B cell scaffold protein with ankyrin repeats 1)	protein interactions	55024	10	1	19454	50	ITPR2
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	ZNF135 (zinc finger protein 135)	protein interactions	7694	10	1	19454	50	WWOX
2.541e-02	-3.67	ALKAL2 (ALK and LTK ligand 2)	protein interactions	285016	10	1	19454	50	PON2
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	ZNF852 (zinc finger protein 852)	protein interactions	285346	10	1	19454	50	ARHGAP24
2.541e-02	-3.67	ZNF606 (zinc finger protein 606)	protein interactions	80095	10	1	19454	50	ARHGAP24
2.548e-02	-3.67	protein tetramerization	biological process	GO:0051262	92	2	18204	49	AQP4,RYR3
2.551e-02	-3.67	lipid binding	molecular function	GO:0008289	861	6	18094	48	ATP1A2,PARD3B,PTGDS,PITPNC1,ITPR2,RORA
2.566e-02	-3.66	GS	smart domains	SM00467	7	1	9717	36	BMPR1B
2.580e-02	-3.66	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	2	7161	22	CAMK2G,ITPR2
2.580e-02	-3.66	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	2	7161	22	CAMK2G,ITPR2
2.586e-02	-3.66	parotid	COSMIC cancer mutations	parotid	578	5	16828	49	RYR3,CKB,ERBB4,CAMK2G,TNIK
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.616e-02	-3.64	muscle contraction	biological process	GO:0006936	238	3	18204	49	RYR3,ATP1A2,DTNA
2.621e-02	-3.64	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	44	16828	49	NEBL,SLC1A3,ARHGAP24,ZNRF3,ITPR2,ERBB4,NPAS3,PARD3B,CKB,PTGDS,CAMK2G,PON2,CLU,CST3,LRIG1,RYR3,SLC4A4,NTM,GPC5,QKI,BMPR1B,PAMR1,SOX5,HPSE2,SFXN5,NRXN1,COL5A3,SLC1A2,NKAIN3,PREX2,LSAMP,AQP4,FBXL7,CDH20,GPM6A,RORA,TNIK,SPARCL1,ZBTB20,NHSL1,ATP13A4,CTNND2,GLIS3,ATP1A2
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.622e-02	-3.64	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	48	ATP13A4
2.631e-02	-3.64	MED27 (mediator complex subunit 27)	protein interactions	9442	98	2	19454	50	QKI,SOX5
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	LSAMP,GPM6A
2.646e-02	-3.63	human chr2p13.2	chromosome location	human chr2p13.2	14	1	26134	50	SFXN5
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.653e-02	-3.63	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	39	16828	49	RORA,TNIK,LRIG1,RYR3,SPARCL1,SLC4A4,GPC5,QKI,NTM,NHSL1,PAMR1,BMPR1B,WWOX,SOX5,CTNND2,HPSE2,ATP13A4,SFXN5,ATP1A2,GLIS3,SLC1A3,NEBL,ARHGAP24,NRXN1,ITPR2,ERBB4,MSI2,SLC1A2,COL5A3,NKAIN3,PREX2,NPAS3,DTNA,PARD3B,LSAMP,CAMK2G,PON2,FBXL7,CDH20
2.654e-02	-3.63	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	49	ERBB4,PARD3B,ITPR2,SLC4A4,PREX2
2.660e-02	-3.63	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	49	SOX5
2.660e-02	-3.63	neuronal action potential propagation	biological process	GO:0019227	10	1	18204	49	ATP1A2
2.660e-02	-3.63	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	1	18204	49	NRXN1
2.660e-02	-3.63	establishment of centrosome localization	biological process	GO:0051660	10	1	18204	49	PARD3B
2.660e-02	-3.63	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	49	NRXN1
2.660e-02	-3.63	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	49	RYR3
2.660e-02	-3.63	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	49	NRXN1
2.660e-02	-3.63	action potential propagation	biological process	GO:0098870	10	1	18204	49	ATP1A2
2.660e-02	-3.63	otolith development	biological process	GO:0048840	10	1	18204	49	LRIG1
2.660e-02	-3.63	mitochondrial fragmentation involved in apoptotic process	biological process	GO:0043653	10	1	18204	49	ERBB4
2.666e-02	-3.62	Ig_sub2	interpro domains	IPR003598	239	3	18521	50	NTM,LRIG1,LSAMP
2.668e-02	-3.62	MIP_CS	interpro domains	IPR022357	10	1	18521	50	AQP4
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.683e-02	-3.62	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	48	ATP1A2,ATP13A4
2.693e-02	-3.61	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	3	19454	50	ERBB4,TNIK,NHSL1
2.695e-02	-3.61	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	22	16828	49	RORA,TNIK,LRIG1,SPARCL1,QKI,SOX5,BMPR1B,ATP13A4,CTNND2,PITPNC1,SLC1A3,ARHGAP24,COL5A3,ERBB4,MSI2,ITPR2,NPAS3,PREX2,LSAMP,CLU,CAMK2G,FBXL7
2.695e-02	-3.61	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	22	16828	49	RORA,TNIK,LRIG1,SPARCL1,QKI,BMPR1B,SOX5,ATP13A4,CTNND2,PITPNC1,SLC1A3,ARHGAP24,ITPR2,COL5A3,MSI2,ERBB4,NPAS3,PREX2,LSAMP,CAMK2G,CLU,FBXL7
2.701e-02	-3.61	anchoring junction	cellular component	GO:0070161	902	6	19108	49	CTNNA2,ATP1A2,CDH20,CTNND2,ARHGAP24,PARD3B
2.704e-02	-3.61	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	49	ITPR2,RYR3
2.731e-02	-3.60	EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2)	protein interactions	55741	100	2	19454	50	HPSE2,CLU
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	ATP1A2,GPM6A
2.733e-02	-3.60	Heparan sulfate degradation	KEGG pathways	M00078	9	1	7161	22	HPSE2
2.733e-02	-3.60	Heparan sulfate degradation	KEGG pathways	hsa_M00078	9	1	7161	22	HPSE2
2.758e-02	-3.59	ErbB signaling pathway	KEGG pathways	ko04012	85	2	7161	22	ERBB4,CAMK2G
2.758e-02	-3.59	ErbB signaling pathway	KEGG pathways	hsa04012	85	2	7161	22	CAMK2G,ERBB4
2.758e-02	-3.59	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	22	CAMK2G,ATP1A2
2.767e-02	-3.59	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	32	CLU
2.767e-02	-3.59	Synthesis of 5-eicosatetraenoic acids	REACTOME pathways	R-HSA-2142688	9	1	10285	32	PON2
2.775e-02	-3.58	HCO3_cotransp	pfam domains	PF00955	10	1	17795	50	SLC4A4
2.775e-02	-3.58	PAS_3	pfam domains	PF08447	10	1	17795	50	NPAS3
2.780e-02	-3.58	signaling	biological process	GO:0023052	4968	20	18204	49	SPARCL1,BMPR1B,SLC1A3,NRXN1,TNIK,SLC1A2,CTNND2,ARHGAP24,PITPNC1,PREX2,CAMK2G,ITPR2,ATP1A2,ERBB4,CLU,RORA,WWOX,ZNRF3,RYR3,DTNA
2.786e-02	-3.58	platelet dense tubular network	cellular component	GO:0031094	11	1	19108	49	ITPR2
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.792e-02	-3.58	VOPP1 (VOPP1 WW domain binding protein)	protein interactions	81552	11	1	19454	50	WWOX
2.792e-02	-3.58	IL7 (interleukin 7)	protein interactions	3574	11	1	19454	50	QKI
2.792e-02	-3.58	PTGDR (prostaglandin D2 receptor)	protein interactions	5729	11	1	19454	50	PTGDS
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	ZNF726 (zinc finger protein 726)	protein interactions	730087	11	1	19454	50	ARHGAP24
2.792e-02	-3.58	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	50	NRXN1
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	ITPR2
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	GAL3ST1 (galactose-3-O-sulfotransferase 1)	protein interactions	9514	11	1	19454	50	LRIG1
2.792e-02	-3.58	DAZ1 (deleted in azoospermia 1)	protein interactions	1617	11	1	19454	50	QKI
2.810e-02	-3.57	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	49	SLC1A3,SLC1A2
2.810e-02	-3.57	nerve development	biological process	GO:0021675	97	2	18204	49	SLC1A3,LRIG1
2.814e-02	-3.57	basolateral plasma membrane	cellular component	GO:0016323	257	3	19108	49	SLC4A4,AQP4,ERBB4
2.819e-02	-3.57	PRMT5 (protein arginine methyltransferase 5)	protein interactions	10419	450	4	19454	50	GLIS3,ARHGAP24,WWOX,RORA
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	MIR7-1 (microRNA 7-1)	protein interactions	407043	102	2	19454	50	QKI,MSI2
2.832e-02	-3.56	KRTAP6-1 (keratin associated protein 6-1)	protein interactions	337966	102	2	19454	50	CAMK2G,GLIS3
2.842e-02	-3.56	trans-synaptic signaling	biological process	GO:0099537	431	4	18204	49	SLC1A3,SLC1A2,DTNA,NRXN1
2.847e-02	-3.56	regulation of synapse organization	biological process	GO:0050807	246	3	18204	49	GPM6A,CTNNA2,NRXN1
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.875e-02	-3.55	chiasm	COSMIC cancer mutations	chiasm	10	1	16828	49	QKI
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.880e-02	-3.55	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	48	NRXN1
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	GPM6A,BMPR1B
2.885e-02	-3.55	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	49	ATP13A4,SLC1A3,RYR3,ATP1A2
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A3,SLC1A2
2.897e-02	-3.54	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	3	16828	49	HPSE2,CTNND2,ERBB4
2.906e-02	-3.54	HNRNPK (heterogeneous nuclear ribonucleoprotein K)	protein interactions	3190	675	5	19454	50	QKI,ARHGAP24,DTNA,WWOX,CKB
2.920e-02	-3.53	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	4	19454	50	DTNA,CAMK2G,ERBB4,CTNND2
2.922e-02	-3.53	cellular response to caffeine	biological process	GO:0071313	11	1	18204	49	RYR3
2.922e-02	-3.53	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	49	ATP1A2
2.922e-02	-3.53	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	biological process	GO:2001241	11	1	18204	49	WWOX
2.922e-02	-3.53	lactone metabolic process	biological process	GO:1901334	11	1	18204	49	ATP1A2
2.922e-02	-3.53	polyamine transport	biological process	GO:0015846	11	1	18204	49	ATP13A4
2.922e-02	-3.53	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	49	BMPR1B
2.922e-02	-3.53	intracellular mRNA localization	biological process	GO:0008298	11	1	18204	49	QKI
2.922e-02	-3.53	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	49	ATP1A2
2.927e-02	-3.53	blood vessel morphogenesis	biological process	GO:0048514	435	4	18204	49	ARHGAP24,RORA,GLUL,QKI
2.931e-02	-3.53	Fib_collagen_C	interpro domains	IPR000885	11	1	18521	50	COL5A3
2.936e-02	-3.53	CYP2C9 (cytochrome P450 family 2 subfamily C member 9)	protein interactions	1559	104	2	19454	50	ITPR2,WWOX
2.936e-02	-3.53	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	2	19454	50	CLU,SPARCL1
2.997e-02	-3.51	calcium ion transport	biological process	GO:0006816	251	3	18204	49	ITPR2,RYR3,GPM6A
3.000e-02	-3.51	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	44	SLC4A4
3.003e-02	-3.51	Protein digestion and absorption	KEGG pathways	hsa04974	89	2	7161	22	ATP1A2,COL5A3
3.003e-02	-3.51	Protein digestion and absorption	KEGG pathways	ko04974	89	2	7161	22	COL5A3,ATP1A2
3.021e-02	-3.50	response to organic substance	biological process	GO:0010033	2498	12	18204	49	ITPR2,PTGDS,ATP1A2,CLU,RORA,RYR3,AQP4,GLUL,SLC1A3,ZBTB20,TNIK,SLC1A2
3.022e-02	-3.50	LIPOCALIN	prints domains	PR00179	8	1	5227	20	PTGDS
3.027e-02	-3.50	regulation of synapse structure or activity	biological process	GO:0050803	252	3	18204	49	CTNNA2,NRXN1,GPM6A
3.030e-02	-3.50	cell communication	biological process	GO:0007154	5010	20	18204	49	RORA,CLU,ATP1A2,ERBB4,ZNRF3,WWOX,CAMK2G,ITPR2,DTNA,RYR3,NRXN1,SLC1A2,TNIK,BMPR1B,SPARCL1,SLC1A3,PREX2,PITPNC1,ARHGAP24,CTNND2
3.030e-02	-3.50	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	49	PREX2,CTNND2,ERBB4,LRIG1,ITPR2
3.035e-02	-3.49	banded collagen fibril	cellular component	GO:0098643	12	1	19108	49	COL5A3
3.035e-02	-3.49	fibrillar collagen trimer	cellular component	GO:0005583	12	1	19108	49	COL5A3
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	LOC102724560 (cystathionine beta-synthase like)	protein interactions	102724560	12	1	19454	50	ARHGAP24
3.042e-02	-3.49	LGR5 (leucine rich repeat containing G protein-coupled receptor 5)	protein interactions	8549	12	1	19454	50	ZNRF3
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	SMIM20 (small integral membrane protein 20)	protein interactions	389203	12	1	19454	50	ERBB4
3.042e-02	-3.49	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	50	ERBB4
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	ZNF91 (zinc finger protein 91)	protein interactions	7644	12	1	19454	50	ARHGAP24
3.042e-02	-3.49	ORF17.5 (ORF17.5)	protein interactions	4961482	12	1	19454	50	WWOX
3.042e-02	-3.49	IL15 (interleukin 15)	protein interactions	3600	12	1	19454	50	LRIG1
3.042e-02	-3.49	ZNF235 (zinc finger protein 235)	protein interactions	9310	12	1	19454	50	ARHGAP24
3.042e-02	-3.49	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	50	CLU
3.042e-02	-3.49	UGT1A9 (UDP glucuronosyltransferase family 1 member A9)	protein interactions	54600	12	1	19454	50	PON2
3.049e-02	-3.49	LRRCT	pfam domains	PF01463	11	1	17795	50	LRIG1
3.049e-02	-3.49	COLFI	pfam domains	PF01410	11	1	17795	50	COL5A3
3.058e-02	-3.49	CTNNB1 (catenin beta 1)	protein interactions	1499	926	6	19454	50	CTNNA2,DTNA,NHSL1,PARD3B,ARHGAP24,CTNND2
3.060e-02	-3.49	CYSTATIN	prosite domains	PS00287	9	1	12186	42	CST3
3.069e-02	-3.48	Negative regulation of activity of TFAP2 (AP-2) family transcription factors	REACTOME pathways	R-HSA-8866904	10	1	10285	32	WWOX
3.069e-02	-3.48	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	32	SLC4A4
3.069e-02	-3.48	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	32	ERBB4
3.083e-02	-3.48	response to stimulus	biological process	GO:0050896	7803	28	18204	49	SPARCL1,BMPR1B,SLC1A3,NRXN1,TNIK,SLC1A2,CTNND2,CTNNA2,ITPR2,SOX5,WWOX,PTGDS,AQP4,CST3,RYR3,DTNA,ZBTB20,GPM6A,ARHGAP24,PON2,PREX2,PITPNC1,ATP1A2,ERBB4,CLU,RORA,ZNRF3,GLUL
3.092e-02	-3.48	POMK (protein O-mannose kinase)	protein interactions	84197	266	3	19454	50	PON2,BMPR1B,CLU
3.122e-02	-3.47	Phase I biotransformations, non P450	WikiPathways	WP136	8	1	5310	21	PON2
3.138e-02	-3.46	inositol 1,4,5 trisphosphate binding	molecular function	GO:0070679	12	1	18094	48	ITPR2
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	CLU,GPM6A
3.149e-02	-3.46	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	50	ARHGAP24,NHSL1,CKB,CAMK2G
3.151e-02	-3.46	RET (ret proto-oncogene)	protein interactions	5979	268	3	19454	50	PTGDS,CLU,CKB
3.151e-02	-3.46	protein complex oligomerization	biological process	GO:0051259	256	3	18204	49	RYR3,AQP4,SLC1A2
3.155e-02	-3.46	regulation of multicellular organismal process	biological process	GO:0051239	3113	14	18204	49	SFXN5,CLU,RORA,ERBB4,ATP1A2,PTGDS,CAMK2G,SOX5,GLUL,CST3,NRXN1,BMPR1B,ZBTB20,QKI
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.184e-02	-3.45	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	49	CST3
3.184e-02	-3.45	microglia differentiation	biological process	GO:0014004	12	1	18204	49	QKI
3.184e-02	-3.45	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	49	BMPR1B
3.184e-02	-3.45	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	49	CST3
3.184e-02	-3.45	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	49	BMPR1B
3.184e-02	-3.45	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	49	SLC1A2
3.192e-02	-3.44	GnRH signaling pathway	KEGG pathways	hsa04912	92	2	7161	22	CAMK2G,ITPR2
3.192e-02	-3.44	GnRH signaling pathway	KEGG pathways	ko04912	92	2	7161	22	CAMK2G,ITPR2
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.193e-02	-3.44	Lipocalin_CS	interpro domains	IPR022272	12	1	18521	50	PTGDS
3.193e-02	-3.44	Lipocalin	interpro domains	IPR002345	12	1	18521	50	PTGDS
3.193e-02	-3.44	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	37	16828	49	SLC1A3,NEBL,ARHGAP24,NRXN1,ITPR2,ERBB4,MSI2,COL5A3,SLC1A2,NKAIN3,PREX2,NPAS3,LSAMP,PARD3B,CAMK2G,PON2,FBXL7,CDH20,RORA,TNIK,LRIG1,RYR3,SPARCL1,SLC4A4,GPC5,QKI,NTM,NHSL1,PAMR1,WWOX,SOX5,HPSE2,CTNND2,ATP13A4,ATP1A2,GLIS3,SFXN5
3.193e-02	-3.44	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	37	16828	49	WWOX,SOX5,NHSL1,PAMR1,SFXN5,ATP1A2,GLIS3,HPSE2,CTNND2,ATP13A4,QKI,GPC5,NTM,RYR3,LRIG1,SLC4A4,SPARCL1,RORA,TNIK,CDH20,FBXL7,LSAMP,PARD3B,PON2,CAMK2G,ERBB4,MSI2,COL5A3,SLC1A2,NRXN1,ITPR2,NKAIN3,PREX2,NPAS3,SLC1A3,NEBL,ARHGAP24
3.200e-02	-3.44	ZNRF4 (zinc and ring finger 4)	protein interactions	148066	109	2	19454	50	PON2,ITPR2
3.200e-02	-3.44	MIR34B (microRNA 34b)	protein interactions	407041	109	2	19454	50	MSI2,QKI
3.200e-02	-3.44	NHSL3 (NHS like 3)	protein interactions	57648	109	2	19454	50	WWOX,NHSL1
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	RORA,GPM6A,TNIK,SPARCL1,ZBTB20,NHSL1,GLIS3,ATP1A2,CTNND2,ATP13A4,PITPNC1,GLUL,COL5A3,SLC1A2,NRXN1,PREX2,DTNA,AQP4,LSAMP,CDH20,FBXL7,CST3,RYR3,LRIG1,SLC4A4,GPC5,QKI,NTM,WWOX,SOX5,PAMR1,BMPR1B,SFXN5,HPSE2,SLC1A3,NEBL,ZNRF3,ARHGAP24,ERBB4,MSI2,ITPR2,NPAS3,CKB,PARD3B,CLU,PON2,CAMK2G,PTGDS
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	QKI,GPC5,NTM,WWOX,SOX5,BMPR1B,PAMR1,SFXN5,HPSE2,CST3,RYR3,LRIG1,SLC4A4,CKB,PARD3B,PON2,CLU,CAMK2G,PTGDS,SLC1A3,NEBL,ZNRF3,ARHGAP24,ERBB4,MSI2,ITPR2,NPAS3,ZBTB20,NHSL1,GLIS3,ATP1A2,CTNND2,ATP13A4,RORA,GPM6A,TNIK,SPARCL1,DTNA,LSAMP,AQP4,CDH20,FBXL7,PITPNC1,GLUL,COL5A3,SLC1A2,NRXN1,PREX2
3.240e-02	-3.43	EF-hand-dom_pair	interpro domains	IPR011992	258	3	18521	50	DTNA,RYR3,SPARCL1
3.251e-02	-3.43	neural precursor cell proliferation	biological process	GO:0061351	105	2	18204	49	RORA,SOX5
3.254e-02	-3.43	ZNF581 (zinc finger protein 581)	protein interactions	51545	110	2	19454	50	WWOX,SOX5
3.256e-02	-3.42	SNCA (synuclein alpha)	protein interactions	6622	696	5	19454	50	CKB,CAMK2G,GPM6A,CLU,TNIK
3.271e-02	-3.42	HSPE1 (heat shock protein family E (Hsp10) member 1)	protein interactions	3336	272	3	19454	50	CKB,ERBB4,ARHGAP24
3.275e-02	-3.42	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	49	CTNNA2,TNIK,GPM6A,ARHGAP24,CAMK2G
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	ATP1A2,RORA
3.287e-02	-3.42	FOLN	smart domains	SM00274	9	1	9717	36	SPARCL1
3.291e-02	-3.41	ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5)	protein interactions	8869	13	1	19454	50	PON2
3.291e-02	-3.41	Rbm47 (RNA binding motif protein 47)	protein interactions	245945	13	1	19454	50	QKI
3.291e-02	-3.41	NPR2 (natriuretic peptide receptor 2)	protein interactions	4882	13	1	19454	50	CAMK2G
3.291e-02	-3.41	ZNF718 (zinc finger protein 718)	protein interactions	255403	13	1	19454	50	ARHGAP24
3.291e-02	-3.41	PLPPR4 (phospholipid phosphatase related 4)	protein interactions	9890	13	1	19454	50	ZNRF3
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	50	NRXN1
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.299e-02	-3.41	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	32	NTM,LSAMP
3.347e-02	-3.40	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	7	18204	49	BMPR1B,TNIK,NRXN1,GPM6A,CTNND2,CTNNA2,PREX2
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	GPM6A,ERBB4
3.363e-02	-3.39	ENAH (ENAH actin regulator)	protein interactions	55740	112	2	19454	50	WWOX,ARHGAP24
3.371e-02	-3.39	Creatine metabolism	REACTOME pathways	R-HSA-71288	11	1	10285	32	CKB
3.387e-02	-3.39	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	8	16828	49	PARD3B,NTM,ZBTB20,ERBB4,COL5A3,ATP1A2,NPAS3,SLC4A4
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.395e-02	-3.38	MIP	prosite domains	PS00221	10	1	12186	42	AQP4
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.400e-02	-3.38	calcium ion binding	molecular function	GO:0005509	683	5	18094	48	SPARCL1,ITPR2,RYR3,NRXN1,PAMR1
3.405e-02	-3.38	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	6	19454	50	CTNND2,PON2,ATP13A4,ZBTB20,SLC1A3,CAMK2G
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	DTNA,ZNRF3
3.425e-02	-3.37	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	50	NEBL,GPM6A,SLC1A3
3.439e-02	-3.37	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	49	GPC5,CTNND2,ZNRF3
3.440e-02	-3.37	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-fourth_ventricle-glioma-astrocytoma_Grade_I	12	1	16828	49	QKI
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.444e-02	-3.37	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	49	ATP1A2
3.444e-02	-3.37	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	49	ATP1A2
3.444e-02	-3.37	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	1	18204	49	CLU
3.444e-02	-3.37	prepulse inhibition	biological process	GO:0060134	13	1	18204	49	CTNNA2
3.444e-02	-3.37	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	49	NRXN1
3.444e-02	-3.37	olfactory bulb interneuron differentiation	biological process	GO:0021889	13	1	18204	49	ERBB4
3.444e-02	-3.37	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	49	RORA
3.444e-02	-3.37	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	49	RORA
3.452e-02	-3.37	Circadian entrainment	KEGG pathways	hsa04713	96	2	7161	22	CAMK2G,RYR3
3.452e-02	-3.37	Circadian entrainment	KEGG pathways	ko04713	96	2	7161	22	RYR3,CAMK2G
3.456e-02	-3.37	animal organ development	biological process	GO:0048513	2846	13	18204	49	SOX5,ERBB4,LRIG1,ATP1A2,RORA,WWOX,CKB,GPM6A,CTNNA2,BMPR1B,COL5A3,NEBL,SLC1A2
3.459e-02	-3.36	small molecule binding	molecular function	GO:0036094	6197	23	18094	48	SLC1A3,ZNRF3,ATP1A2,GLIS3,GLUL,NRXN1,RORA,BMPR1B,PITPNC1,SPARCL1,SLC1A2,ITPR2,DTNA,TNIK,CKB,PAMR1,RYR3,CAMK2G,ERBB4,PTGDS,ATP13A4,ZBTB20,PON2
3.466e-02	-3.36	synaptic signaling	biological process	GO:0099536	459	4	18204	49	NRXN1,SLC1A2,DTNA,SLC1A3
3.466e-02	-3.36	small molecule biosynthetic process	biological process	GO:0044283	459	4	18204	49	SLC1A3,QKI,PTGDS,GLUL
3.481e-02	-3.36	long-chain fatty acid metabolic process	biological process	GO:0001676	109	2	18204	49	PTGDS,QKI
3.481e-02	-3.36	postsynapse organization	biological process	GO:0099173	109	2	18204	49	NRXN1,CTNND2
3.481e-02	-3.36	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	2	18204	49	CLU,ZBTB20
3.488e-02	-3.36	PXMP2 (peroxisomal membrane protein 2)	protein interactions	5827	279	3	19454	50	WWOX,GPM6A,ITPR2
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	ITPR2,RYR3
3.506e-02	-3.35	EV release from cardiac cells and their functional effects	WikiPathways	WP3297	9	1	5310	21	ERBB4
3.518e-02	-3.35	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	2	7161	22	CAMK2G,ITPR2
3.518e-02	-3.35	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	2	7161	22	ITPR2,CAMK2G
3.520e-02	-3.35	TSG101 (tumor susceptibility 101)	protein interactions	7251	280	3	19454	50	WWOX,QKI,GLIS3
3.527e-02	-3.34	ACTB (actin beta)	protein interactions	60	958	6	19454	50	NHSL1,SFXN5,ARHGAP24,NEBL,CKB,DTNA
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	SOX5,BMPR1B
3.530e-02	-3.34	LYZ (lysozyme)	protein interactions	4069	115	2	19454	50	CLU,WWOX
3.532e-02	-3.34	chromaffin granule	cellular component	GO:0042583	14	1	19108	49	CLU
3.540e-02	-3.34	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	50	CST3
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	ZNRF3
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.540e-02	-3.34	Plekhg5 (pleckstrin homology domain containing, family G (with RhoGef domain) member 5)	protein interactions	269608	14	1	19454	50	CKB
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	SYT5 (synaptotagmin 5)	protein interactions	6861	14	1	19454	50	NRXN1
3.540e-02	-3.34	C9 (complement C9)	protein interactions	735	14	1	19454	50	CLU
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	CAMK2G
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	50	CAMK2G
3.558e-02	-3.34	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	5	19454	50	DTNA,SLC1A3,ERBB4,MSI2,TNIK
3.559e-02	-3.34	side of membrane	cellular component	GO:0098552	715	5	19108	49	NTM,DTNA,LSAMP,GPC5,AQP4
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.576e-02	-3.33	LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)	protein interactions	55004	714	5	19454	50	CKB,WWOX,DTNA,SLC1A3,TNIK
3.586e-02	-3.33	RBBP8 (RB binding protein 8, endonuclease)	protein interactions	5932	116	2	19454	50	CLU,CTNNA2
3.586e-02	-3.33	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	2	19454	50	GLUL,SPARCL1
3.590e-02	-3.33	-	gene3d domains	3.10.450.50	12	1	14470	44	CAMK2G
3.590e-02	-3.33	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	44	CTNNA2
3.593e-02	-3.33	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	49	GPM6A,ARHGAP24,CAMK2G,CTNNA2,TNIK
3.603e-02	-3.32	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	18	16828	49	PAMR1,CDH20,ATP1A2,ATP13A4,CTNND2,PARD3B,GPC5,QKI,PON2,SLC1A2,COL5A3,ERBB4,LRIG1,ITPR2,SLC4A4,PREX2,RORA,NEBL
3.610e-02	-3.32	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	13	16828	49	LSAMP,CDH20,ATP1A2,ATP13A4,HPSE2,CTNND2,SOX5,NEBL,SLC1A3,PREX2,RYR3,ERBB4,NRXN1
3.612e-02	-3.32	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	49	BMPR1B,ERBB4,CAMK2G,TNIK
3.612e-02	-3.32	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	49	BMPR1B,ERBB4,CAMK2G,TNIK
3.619e-02	-3.32	cell migration	biological process	GO:0016477	921	6	18204	49	GPM6A,ARHGAP24,CTNNA2,GPC5,ERBB4,CDH20
3.642e-02	-3.31	ZBTB33 (zinc finger and BTB domain containing 33)	protein interactions	10009	117	2	19454	50	CTNND2,WWOX
3.646e-02	-3.31	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	5	16828	49	PREX2,CAMK2G,ERBB4,NEBL,NTM
3.647e-02	-3.31	TNPO1 (transportin 1)	protein interactions	3842	284	3	19454	50	WWOX,ARHGAP24,QKI
3.647e-02	-3.31	Dppa3 (developmental pluripotency-associated 3)	protein interactions	73708	284	3	19454	50	CAMK2G,MSI2,ATP1A2
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	ITPR2,PITPNC1,PARD3B
3.672e-02	-3.30	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	32	GPC5
3.672e-02	-3.30	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	32	GPC5
3.680e-02	-3.30	P4HA1 (prolyl 4-hydroxylase subunit alpha 1)	protein interactions	5033	285	3	19454	50	DTNA,WWOX,PON2
3.699e-02	-3.30	DDR1 (discoidin domain receptor tyrosine kinase 1)	protein interactions	780	118	2	19454	50	CLU,WWOX
3.702e-02	-3.30	arm	COSMIC cancer mutations	arm	1331	8	16828	49	ATP1A2,SLC4A4,NPAS3,ERBB4,COL5A3,NTM,PARD3B,ZBTB20
3.704e-02	-3.30	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	49	SLC1A2
3.704e-02	-3.30	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	49	AQP4
3.704e-02	-3.30	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	49	ATP1A2
3.704e-02	-3.30	protein localization to postsynaptic specialization membrane	biological process	GO:0099633	14	1	18204	49	ERBB4
3.704e-02	-3.30	neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0099645	14	1	18204	49	ERBB4
3.704e-02	-3.30	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	49	ATP1A2
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	RYR3
3.704e-02	-3.30	cellular response to ethanol	biological process	GO:0071361	14	1	18204	49	ITPR2
3.704e-02	-3.30	regulation of skeletal muscle adaptation	biological process	GO:0014733	14	1	18204	49	CAMK2G
3.715e-02	-3.29	Neurexin-like	interpro domains	IPR003585	14	1	18521	50	NRXN1
3.715e-02	-3.29	Aquaporin-like	interpro domains	IPR023271	14	1	18521	50	AQP4
3.715e-02	-3.29	MIP	interpro domains	IPR000425	14	1	18521	50	AQP4
3.717e-02	-3.29	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	2	18204	49	CLU,ZBTB20
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-hypothalamus-glioma-astrocytoma_Grade_I	13	1	16828	49	QKI
3.728e-02	-3.29	NC1_FIB	prosite domains	PS51461	11	1	12186	42	COL5A3
3.728e-02	-3.29	LIPOCALIN	prosite domains	PS00213	11	1	12186	42	PTGDS
3.729e-02	-3.29	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	13	16828	49	PARD3B,AQP4,PON2,CAMK2G,GLIS3,CTNND2,RORA,ZNRF3,COL5A3,RYR3,NPAS3,PREX2,SPARCL1
3.729e-02	-3.29	embryonal	COSMIC cancer mutations	embryonal	2659	13	16828	49	CAMK2G,PON2,AQP4,PARD3B,CTNND2,GLIS3,ZNRF3,RORA,SPARCL1,PREX2,NPAS3,RYR3,COL5A3
3.745e-02	-3.28	DHFR2 (dihydrofolate reductase 2)	protein interactions	200895	287	3	19454	50	WWOX,SLC1A3,ITPR2
3.750e-02	-3.28	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	2	16828	49	GPC5,QKI
3.756e-02	-3.28	ENTREP3 (endosomal transmembrane epsin interactor 3)	protein interactions	10712	119	2	19454	50	GPM6A,WWOX
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.764e-02	-3.28	Ion_trans	pfam domains	PF00520	109	2	17795	50	RYR3,ITPR2
3.764e-02	-3.28	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	20	SLC4A4
3.768e-02	-3.28	ATP binding	molecular function	GO:0005524	1467	8	18094	48	BMPR1B,GLUL,ATP1A2,ATP13A4,TNIK,CKB,ERBB4,CAMK2G
3.777e-02	-3.28	regulation of circadian rhythm	biological process	GO:0042752	114	2	18204	49	RORA,PTGDS
3.779e-02	-3.28	NEDD4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	4734	494	4	19454	50	ERBB4,GLIS3,TNIK,CKB
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	ZNF813 (zinc finger protein 813)	protein interactions	126017	15	1	19454	50	ARHGAP24
3.788e-02	-3.27	TESPA1 (thymocyte expressed, positive selection associated 1)	protein interactions	9840	15	1	19454	50	ITPR2
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CLU
3.788e-02	-3.27	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	50	TNIK
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	ZNF616 (zinc finger protein 616)	protein interactions	90317	15	1	19454	50	ARHGAP24
3.788e-02	-3.27	ZNF714 (zinc finger protein 714)	protein interactions	148206	15	1	19454	50	ARHGAP24
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.808e-02	-3.27	telencephalon development	biological process	GO:0021537	276	3	18204	49	SLC1A2,ATP1A2,ERBB4
3.809e-02	-3.27	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	18	16828	49	ATP13A4,CTNND2,ATP1A2,GLIS3,SOX5,AQP4,LSAMP,DTNA,GPC5,SPARCL1,LRIG1,ITPR2,NRXN1,COL5A3,RYR3,ERBB4,TNIK,ZNRF3
3.819e-02	-3.27	circulatory system development	biological process	GO:0072359	933	6	18204	49	NEBL,ERBB4,RORA,ARHGAP24,QKI,GLUL
3.837e-02	-3.26	fatty acid biosynthetic process	biological process	GO:0006633	115	2	18204	49	PTGDS,QKI
3.851e-02	-3.26	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	49	BMPR1B,ERBB4,CAMK2G,TNIK
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	ko04922	102	2	7161	22	ITPR2,CAMK2G
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	hsa04922	102	2	7161	22	CAMK2G,ITPR2
3.864e-02	-3.25	MIP	pfam domains	PF00230	14	1	17795	50	AQP4
3.880e-02	-3.25	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	9	16828	49	RORA,GPC5,LSAMP,ATP1A2,SLC4A4,ATP13A4,COL5A3,SOX5,NRXN1
3.881e-02	-3.25	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	2	16828	49	NEBL,PARD3B
3.908e-02	-3.24	filamin binding	molecular function	GO:0031005	15	1	18094	48	NEBL
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.908e-02	-3.24	tropomyosin binding	molecular function	GO:0005523	15	1	18094	48	NEBL
3.919e-02	-3.24	homeostatic process	biological process	GO:0042592	1456	8	18204	49	ATP1A2,RORA,SLC4A4,ATP13A4,ZBTB20,SLC1A3,AQP4,RYR3
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	DTNA,NHSL1
3.930e-02	-3.24	HK2 (hexokinase 2)	protein interactions	3099	122	2	19454	50	WWOX,PTGDS
3.930e-02	-3.24	SLMAP (sarcolemma associated protein)	protein interactions	7871	122	2	19454	50	TNIK,CAMK2G
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.947e-02	-3.23	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	5	16828	49	CAMK2G,TNIK,PREX2,BMPR1B,ERBB4
3.948e-02	-3.23	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	24	16828	49	DTNA,PON2,CAMK2G,SLC1A3,NEBL,ERBB4,COL5A3,ITPR2,PREX2,NKAIN3,NPAS3,ZBTB20,SOX5,PAMR1,GLIS3,ATP1A2,CTNND2,ATP13A4,CST3,RORA,RYR3,LRIG1,SLC4A4,SPARCL1
3.959e-02	-3.23	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	5	RORA
3.963e-02	-3.23	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	47	16828	49	SPARCL1,TNIK,RORA,GPM6A,GLIS3,ATP1A2,CTNND2,ATP13A4,NHSL1,ZBTB20,NKAIN3,PREX2,SLC1A2,COL5A3,NRXN1,PITPNC1,GLUL,CDH20,FBXL7,DTNA,AQP4,LSAMP,SLC4A4,RYR3,LRIG1,SFXN5,HPSE2,WWOX,SOX5,BMPR1B,PAMR1,GPC5,QKI,NTM,NPAS3,ERBB4,MSI2,ITPR2,ZNRF3,ARHGAP24,SLC1A3,NEBL,CLU,PON2,CAMK2G,PTGDS,PARD3B
3.964e-02	-3.23	system process	biological process	GO:0003008	2015	10	18204	49	AQP4,RYR3,DTNA,CTNNA2,SLC1A3,SLC4A4,ATP1A2,NRXN1,LRIG1,SLC1A2
3.964e-02	-3.23	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	49	ATP1A2
3.964e-02	-3.23	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	49	ATP1A2
3.964e-02	-3.23	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	49	RYR3
3.964e-02	-3.23	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	49	RORA
3.964e-02	-3.23	regulation of circadian sleep/wake cycle, sleep	biological process	GO:0045187	15	1	18204	49	PTGDS
3.964e-02	-3.23	protein homotrimerization	biological process	GO:0070207	15	1	18204	49	SLC1A2
3.964e-02	-3.23	neuroblast division	biological process	GO:0055057	15	1	18204	49	SOX5
3.964e-02	-3.23	response to caffeine	biological process	GO:0031000	15	1	18204	49	RYR3
3.967e-02	-3.23	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	46	16828	49	FBXL7,CDH20,LSAMP,AQP4,DTNA,NRXN1,SLC1A2,COL5A3,NKAIN3,PREX2,GLUL,PITPNC1,NHSL1,ATP13A4,CTNND2,ATP1A2,GLIS3,ZBTB20,SPARCL1,GPM6A,RORA,TNIK,PARD3B,CKB,CAMK2G,PON2,CLU,ITPR2,ERBB4,NPAS3,NEBL,SLC1A3,ARHGAP24,ZNRF3,BMPR1B,PAMR1,SOX5,WWOX,HPSE2,SFXN5,NTM,GPC5,QKI,LRIG1,RYR3,SLC4A4
3.972e-02	-3.23	Passive transport by Aquaporins	REACTOME pathways	R-HSA-432047	13	1	10285	32	AQP4
3.972e-02	-3.23	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	32	ERBB4
3.972e-02	-3.23	Activation of the TFAP2 (AP-2) family of transcription factors	REACTOME pathways	R-HSA-8866907	13	1	10285	32	WWOX
3.972e-02	-3.23	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	32	ITPR2
3.975e-02	-3.23	NTF2-like_dom_sf	interpro domains	IPR032710	15	1	18521	50	CAMK2G
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
4.003e-02	-3.22	COLFI	smart domains	SM00038	11	1	9717	36	COL5A3
4.008e-02	-3.22	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	4	12186	42	ERBB4,CAMK2G,BMPR1B,TNIK
4.015e-02	-3.22	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	18	16828	49	SLC1A3,RORA,ZNRF3,RYR3,COL5A3,PREX2,NPAS3,SPARCL1,AQP4,PARD3B,PON2,CLU,CAMK2G,NHSL1,PAMR1,GLIS3,CDH20,CTNND2
4.023e-02	-3.21	Prot_kinase_dom	interpro domains	IPR000719	480	4	18521	50	TNIK,ERBB4,CAMK2G,BMPR1B
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.033e-02	-3.21	trunk	COSMIC cancer mutations	trunk	3554	16	16828	49	NEBL,SLC1A3,SPARCL1,NPAS3,PREX2,NRXN1,RYR3,ERBB4,LSAMP,ATP13A4,CTNND2,HPSE2,CDH20,ATP1A2,GLIS3,SOX5
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	DUS1L (dihydrouridine synthase 1 like)	protein interactions	64118	16	1	19454	50	CAMK2G
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	50	NRXN1
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	50	NRXN1
4.035e-02	-3.21	TMEM134 (transmembrane protein 134)	protein interactions	80194	16	1	19454	50	ERBB4
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	ZNRF3
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	CAMK1G (calcium/calmodulin dependent protein kinase IG)	protein interactions	57172	16	1	19454	50	CAMK2G
4.035e-02	-3.21	NBL1 (NBL1, DAN family BMP antagonist)	protein interactions	4681	16	1	19454	50	LRIG1
4.035e-02	-3.21	SYT4 (synaptotagmin 4)	protein interactions	6860	16	1	19454	50	NRXN1
4.035e-02	-3.21	TMEM92 (transmembrane protein 92)	protein interactions	162461	16	1	19454	50	WWOX
4.035e-02	-3.21	GMPR2 (guanosine monophosphate reductase 2)	protein interactions	51292	16	1	19454	50	ARHGAP24
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	Sumo3 (small ubiquitin-like modifier 3)	protein interactions	20610	16	1	19454	50	ITPR2
4.043e-02	-3.21	cell projection organization	biological process	GO:0030030	1200	7	18204	49	TNIK,PREX2,CTNNA2,NRXN1,GPM6A,CTNND2,BMPR1B
4.053e-02	-3.21	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	7	16828	49	COL5A3,ERBB4,NTM,SLC4A4,PREX2,ATP13A4,CTNND2
4.065e-02	-3.20	membrane protein complex	cellular component	GO:0098796	1261	7	19108	49	CTNNA2,SLC1A2,ATP1A2,SLC1A3,CDH20,RYR3,BMPR1B
4.079e-02	-3.20	H2BC9 (H2B clustered histone 9)	protein interactions	8345	297	3	19454	50	ARHGAP24,HPSE2,PREX2
4.082e-02	-3.20	metal ion binding	molecular function	GO:0046872	4239	17	18094	48	GLUL,NRXN1,ATP13A4,ZBTB20,PON2,RORA,BMPR1B,GLIS3,ATP1A2,PAMR1,ZNRF3,RYR3,SLC1A3,DTNA,SPARCL1,SLC1A2,ITPR2
4.083e-02	-3.20	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	12	16828	49	SLC1A3,PARD3B,ZNRF3,CLU,PON2,RYR3,PAMR1,NHSL1,NPAS3,CDH20,PREX2,SPARCL1
4.083e-02	-3.20	alveolar	COSMIC cancer mutations	alveolar	2414	12	16828	49	SLC1A3,ZNRF3,RYR3,SPARCL1,NPAS3,PREX2,PARD3B,CLU,PON2,PAMR1,NHSL1,CDH20
4.106e-02	-3.19	SOCS6 (suppressor of cytokine signaling 6)	protein interactions	9306	125	2	19454	50	BMPR1B,ERBB4
4.106e-02	-3.19	TCHP (trichoplein keratin filament binding)	protein interactions	84260	125	2	19454	50	WWOX,GLUL
4.116e-02	-3.19	regulation of localization	biological process	GO:0032879	2028	10	18204	49	SLC1A2,ERBB4,ATP1A2,NKAIN3,CLU,GPC5,ITPR2,CAMK2G,GLUL,RYR3
4.117e-02	-3.19	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	48	SLC1A2,SLC4A4,SLC1A3
4.118e-02	-3.19	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	10	16828	49	HPSE2,FBXL7,ATP13A4,PREX2,CDH20,ERBB4,RYR3,COL5A3,PITPNC1,NEBL
4.131e-02	-3.19	extremity	COSMIC cancer mutations	extremity	1876	10	16828	49	PITPNC1,NEBL,ERBB4,COL5A3,RYR3,PREX2,CDH20,FBXL7,HPSE2,ATP13A4
4.134e-02	-3.19	CNH	pfam domains	PF00780	15	1	17795	50	TNIK
4.134e-02	-3.19	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	50	ATP1A2
4.163e-02	-3.18	misfolded protein binding	molecular function	GO:0051787	16	1	18094	48	CLU
4.163e-02	-3.18	water channel activity	molecular function	GO:0015250	16	1	18094	48	AQP4
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.166e-02	-3.18	RNF115 (ring finger protein 115)	protein interactions	27246	126	2	19454	50	CST3,GLUL
4.176e-02	-3.18	Glycerol uptake facilitator protein	gene3d domains	1.20.1080.10	14	1	14470	44	AQP4
4.223e-02	-3.16	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	49	ZNRF3
4.223e-02	-3.16	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	49	ATP1A2
4.223e-02	-3.16	asymmetric cell division	biological process	GO:0008356	16	1	18204	49	SOX5
4.223e-02	-3.16	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	49	SLC1A2
4.223e-02	-3.16	glutamine family amino acid biosynthetic process	biological process	GO:0009084	16	1	18204	49	GLUL
4.223e-02	-3.16	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	49	ATP1A2
4.223e-02	-3.16	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	49	SLC1A3
4.223e-02	-3.16	neuron cell-cell adhesion	biological process	GO:0007158	16	1	18204	49	NRXN1
4.223e-02	-3.16	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	49	ATP1A2
4.223e-02	-3.16	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	49	ATP1A2
4.223e-02	-3.16	wound healing, spreading of epidermal cells	biological process	GO:0035313	16	1	18204	49	ARHGAP24
4.223e-02	-3.16	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	3	16828	49	CDH20,SOX5,RYR3
4.271e-02	-3.15	muscle cell differentiation	biological process	GO:0042692	289	3	18204	49	NEBL,QKI,RORA
4.271e-02	-3.15	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	32	ERBB4
4.273e-02	-3.15	apical dendrite	cellular component	GO:0097440	17	1	19108	49	CLU
4.274e-02	-3.15	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	7	16828	49	RORA,CKB,CAMK2G,TNIK,RYR3,ERBB4,CTNND2
4.282e-02	-3.15	hypothalamus	COSMIC cancer mutations	hypothalamus	15	1	16828	49	QKI
4.282e-02	-3.15	SHD (Src homology 2 domain containing transforming protein D)	protein interactions	56961	17	1	19454	50	ERBB4
4.282e-02	-3.15	ZNF557 (zinc finger protein 557)	protein interactions	79230	17	1	19454	50	ARHGAP24
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	FAM163B (family with sequence similarity 163 member B)	protein interactions	642968	17	1	19454	50	CAMK2G
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	KRTAP19-3 (keratin associated protein 19-3)	protein interactions	337970	17	1	19454	50	CAMK2G
4.282e-02	-3.15	Pef1 (penta-EF hand domain containing 1)	protein interactions	67898	17	1	19454	50	QKI
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.286e-02	-3.15	PPIB (peptidylprolyl isomerase B)	protein interactions	5479	303	3	19454	50	ARHGAP24,CKB,WWOX
4.311e-02	-3.14	human chr2q34	chromosome location	human chr2q34	23	1	26134	50	ERBB4
4.313e-02	-3.14	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	5	ATP1A2
4.313e-02	-3.14	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	5	ATP1A2
4.329e-02	-3.14	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	49	ERBB4,BMPR1B,TNIK,CAMK2G
4.334e-02	-3.14	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	5	16828	49	ERBB4,BMPR1B,TNIK,SPARCL1,CAMK2G
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	SOX5,ZBTB20
4.346e-02	-3.14	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	2	19454	50	ZBTB20,ITPR2
4.350e-02	-3.13	cellular response to growth factor stimulus	biological process	GO:0071363	494	4	18204	49	BMPR1B,SOX5,ERBB4,WWOX
4.352e-02	-3.13	skin-chest-malignant_melanoma	COSMIC cancer mutations	skin-chest-malignant_melanoma	114	2	16828	49	ERBB4,PREX2
4.356e-02	-3.13	ATAD3A (ATPase family AAA domain containing 3A)	protein interactions	55210	305	3	19454	50	ARHGAP24,WWOX,SOX5
4.362e-02	-3.13	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	6	16828	49	ITPR2,LRIG1,PTGDS,SPARCL1,NPAS3,ATP1A2
4.366e-02	-3.13	channel activity	molecular function	GO:0015267	502	4	18094	48	GPM6A,RYR3,AQP4,ITPR2
4.388e-02	-3.13	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	49	CAMK2G,TNIK,BMPR1B,ERBB4
4.388e-02	-3.13	Z disc	cellular component	GO:0030018	130	2	19108	49	RYR3,NEBL
4.392e-02	-3.13	passive transmembrane transporter activity	molecular function	GO:0022803	503	4	18094	48	GPM6A,ITPR2,AQP4,RYR3
4.407e-02	-3.12	RSPH1 (radial spoke head component 1)	protein interactions	89765	130	2	19454	50	GLUL,CLU
4.407e-02	-3.12	DVL1 (dishevelled segment polarity protein 1)	protein interactions	1855	130	2	19454	50	WWOX,ZNRF3
4.419e-02	-3.12	CDH1 (cadherin 1)	protein interactions	999	757	5	19454	50	CTNNA2,WWOX,NHSL1,CTNND2,NEBL
4.428e-02	-3.12	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	5	16828	49	SPARCL1,CAMK2G,TNIK,BMPR1B,ERBB4
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	SLC1A2
4.481e-02	-3.11	cGMP metabolic process	biological process	GO:0046068	17	1	18204	49	RORA
4.481e-02	-3.11	reverse cholesterol transport	biological process	GO:0043691	17	1	18204	49	CLU
4.481e-02	-3.11	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	49	CTNNA2
4.481e-02	-3.11	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	49	RORA
4.481e-02	-3.11	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	49	CLU
4.481e-02	-3.11	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	49	ATP1A2
4.481e-02	-3.11	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	49	ERBB4
4.481e-02	-3.11	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	49	ATP1A2
4.481e-02	-3.11	microvillus assembly	biological process	GO:0030033	17	1	18204	49	TNIK
4.481e-02	-3.11	regulation of amyloid fibril formation	biological process	GO:1905906	17	1	18204	49	CLU
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	RYR3
4.493e-02	-3.10	Cystatin_dom	interpro domains	IPR000010	17	1	18521	50	CST3
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	CKB,PARD3B,PON2,CLU,PTGDS,CAMK2G,NEBL,SLC1A3,ZNRF3,ARHGAP24,MSI2,ERBB4,ITPR2,NPAS3,NTM,QKI,GPC5,SOX5,WWOX,PAMR1,BMPR1B,SFXN5,HPSE2,CST3,RYR3,LRIG1,SLC4A4,AQP4,LSAMP,DTNA,CDH20,FBXL7,PITPNC1,GLUL,COL5A3,SLC1A2,NRXN1,NKAIN3,PREX2,ZBTB20,NHSL1,GLIS3,ATP1A2,ATP13A4,CTNND2,RORA,GPM6A,TNIK,SPARCL1
4.525e-02	-3.10	kinase activity	molecular function	GO:0016301	739	5	18094	48	BMPR1B,ERBB4,CAMK2G,TNIK,CKB
4.529e-02	-3.09	AK9 (adenylate kinase 9)	protein interactions	221264	18	1	19454	50	ARHGAP24
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	ZNF100 (zinc finger protein 100)	protein interactions	163227	18	1	19454	50	ARHGAP24
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	PTGFR (prostaglandin F receptor)	protein interactions	5737	18	1	19454	50	PTGDS
4.530e-02	-3.09	STRN (striatin)	protein interactions	6801	132	2	19454	50	CAMK2G,TNIK
4.530e-02	-3.09	DDR2 (discoidin domain receptor tyrosine kinase 2)	protein interactions	4921	132	2	19454	50	CLU,CKB
4.534e-02	-3.09	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	3	10285	32	ERBB4,CAMK2G,ITPR2
4.547e-02	-3.09	phosphorylation	biological process	GO:0016310	729	5	18204	49	CKB,CAMK2G,BMPR1B,ERBB4,TNIK
4.557e-02	-3.09	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	7	16828	49	RYR3,ERBB4,CTNND2,RORA,CKB,TNIK,CAMK2G
4.563e-02	-3.09	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	25	16828	49	CDH20,FBXL7,PARD3B,CLU,ERBB4,COL5A3,SLC1A2,PREX2,NPAS3,SLC1A3,PITPNC1,SOX5,NHSL1,PAMR1,SFXN5,CTNND2,HPSE2,ZBTB20,GPC5,QKI,NTM,RYR3,SLC4A4,RORA,GPM6A
4.565e-02	-3.09	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	49	BMPR1B,ERBB4,CAMK2G,TNIK
4.569e-02	-3.09	carboxylic acid transport	biological process	GO:0046942	297	3	18204	49	SFXN5,SLC1A2,SLC1A3
4.569e-02	-3.09	muscle system process	biological process	GO:0003012	297	3	18204	49	RYR3,DTNA,ATP1A2
4.569e-02	-3.09	Cholinergic synapse	KEGG pathways	hsa04725	112	2	7161	22	ITPR2,CAMK2G
4.570e-02	-3.09	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	32	ERBB4
4.570e-02	-3.09	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME pathways	R-HSA-2162123	15	1	10285	32	PTGDS
4.606e-02	-3.08	extraskeletal	COSMIC cancer mutations	extraskeletal	903	6	16828	49	ITPR2,LRIG1,PTGDS,SPARCL1,NPAS3,ATP1A2
4.607e-02	-3.08	organic acid transport	biological process	GO:0015849	298	3	18204	49	SFXN5,SLC1A2,SLC1A3
4.613e-02	-3.08	PDZ	pfam domains	PF00595	122	2	17795	50	PARD3B,PREX2
4.621e-02	-3.07	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	8	18094	48	BMPR1B,ATP13A4,CKB,TNIK,ATP1A2,GLUL,ERBB4,CAMK2G
4.629e-02	-3.07	Circadian rythm related genes	WikiPathways	WP3594	207	3	5310	21	PTGDS,CST3,RORA
4.649e-02	-3.07	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	21	RYR3
4.649e-02	-3.07	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	21	BMPR1B
4.652e-02	-3.07	cellular response to organonitrogen compound	biological process	GO:0071417	505	4	18204	49	ITPR2,SLC1A3,RYR3,SLC1A2
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	NTM,GPM6A
4.655e-02	-3.07	myelination	biological process	GO:0042552	128	2	18204	49	CLU,QKI
4.662e-02	-3.07	ENO1 (enolase 1)	protein interactions	2023	529	4	19454	50	CKB,WWOX,ARHGAP24,GLIS3
4.665e-02	-3.07	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	5	ATP1A2
4.671e-02	-3.06	GABA receptor binding	molecular function	GO:0050811	18	1	18094	48	ERBB4
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.671e-02	-3.06	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	1	18094	48	HPSE2
4.673e-02	-3.06	ZZ	pfam domains	PF00569	17	1	17795	50	DTNA
4.673e-02	-3.06	Cystatin	pfam domains	PF00031	17	1	17795	50	CST3
4.674e-02	-3.06	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	5	19454	50	PON2,ERBB4,MSI2,CLU,SLC1A2
4.680e-02	-3.06	ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2)	protein interactions	10425	314	3	19454	50	WWOX,CKB,GLUL
4.716e-02	-3.05	BMP4 (bone morphogenetic protein 4)	protein interactions	652	135	2	19454	50	BMPR1B,CLU
4.716e-02	-3.05	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	2	19454	50	DTNA,ERBB4
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	ITPR2,CAMK2G
4.720e-02	-3.05	response to organophosphorus	biological process	GO:0046683	129	2	18204	49	ITPR2,RYR3
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	AQP4,LSAMP,DTNA,CDH20,FBXL7,PITPNC1,GLUL,SLC1A2,COL5A3,NRXN1,PREX2,NKAIN3,ZBTB20,NHSL1,GLIS3,ATP1A2,ATP13A4,CTNND2,RORA,GPM6A,TNIK,SPARCL1,CKB,PARD3B,PON2,CLU,PTGDS,CAMK2G,NEBL,SLC1A3,ZNRF3,ARHGAP24,ERBB4,MSI2,ITPR2,NPAS3,NTM,GPC5,QKI,SOX5,WWOX,BMPR1B,PAMR1,SFXN5,HPSE2,CST3,RYR3,LRIG1,SLC4A4
4.737e-02	-3.05	circulatory system process	biological process	GO:0003013	508	4	18204	49	SLC1A3,ATP1A2,SLC4A4,SLC1A2
4.738e-02	-3.05	receptor catabolic process	biological process	GO:0032801	18	1	18204	49	ZNRF3
4.738e-02	-3.05	myelin maintenance	biological process	GO:0043217	18	1	18204	49	CLU
4.738e-02	-3.05	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	49	RORA
4.738e-02	-3.05	dicarboxylic acid catabolic process	biological process	GO:0043649	18	1	18204	49	GLUL
4.738e-02	-3.05	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	49	CST3
4.738e-02	-3.05	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	49	ATP1A2
4.738e-02	-3.05	response to misfolded protein	biological process	GO:0051788	18	1	18204	49	CLU
4.738e-02	-3.05	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	49	CTNND2
4.738e-02	-3.05	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	49	NEBL
4.743e-02	-3.05	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	18	16828	49	COL5A3,RYR3,SPARCL1,PREX2,NPAS3,SLC1A3,RORA,ZNRF3,NHSL1,PAMR1,CTNND2,GLIS3,CDH20,AQP4,PARD3B,CAMK2G,CLU,PON2
4.752e-02	-3.05	Furin_repeat	interpro domains	IPR006212	18	1	18521	50	ERBB4
4.752e-02	-3.05	Leu-rich_rpt_Cys-con_subtyp	interpro domains	IPR006553	18	1	18521	50	FBXL7
4.752e-02	-3.05	Leu-rich_rpt_4	interpro domains	IPR025875	18	1	18521	50	LRIG1
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	ERBB4,TNIK,CTNND2
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	HBEGF (heparin binding EGF like growth factor)	protein interactions	1839	19	1	19454	50	ERBB4
4.774e-02	-3.04	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	50	NRXN1
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	ZNF138 (zinc finger protein 138)	protein interactions	7697	19	1	19454	50	ARHGAP24
4.774e-02	-3.04	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	50	CAMK2G
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	ZNF532 (zinc finger protein 532)	protein interactions	55205	19	1	19454	50	ERBB4
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)	protein interactions	6236	19	1	19454	50	CAMK2G
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	MYOZ2 (myozenin 2)	protein interactions	51778	19	1	19454	50	WWOX
4.774e-02	-3.04	Mtx1 (metaxin 1)	protein interactions	17827	19	1	19454	50	CAMK2G
4.774e-02	-3.04	NLGN1 (neuroligin 1)	protein interactions	22871	19	1	19454	50	NRXN1
4.779e-02	-3.04	NIBAN2 (niban apoptosis regulator 2)	protein interactions	64855	136	2	19454	50	ARHGAP24,GLUL
4.786e-02	-3.04	ensheathment of neurons	biological process	GO:0007272	130	2	18204	49	QKI,CLU
4.786e-02	-3.04	axon ensheathment	biological process	GO:0008366	130	2	18204	49	QKI,CLU
4.824e-02	-3.03	animal organ morphogenesis	biological process	GO:0009887	988	6	18204	49	BMPR1B,SOX5,ERBB4,LRIG1,CTNNA2,WWOX
4.839e-02	-3.03	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-optic_nerve-glioma-astrocytoma_Grade_I	17	1	16828	49	QKI
4.839e-02	-3.03	optic_nerve	COSMIC cancer mutations	optic_nerve	17	1	16828	49	QKI
4.843e-02	-3.03	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	49	DTNA,CDH20
4.852e-02	-3.03	carboxylic acid transmembrane transport	biological process	GO:1905039	131	2	18204	49	SLC1A3,SLC1A2
4.856e-02	-3.02	protein-folding chaperone binding	molecular function	GO:0051087	133	2	18094	48	CLU,ATP1A2
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.867e-02	-3.02	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	1	10285	32	ERBB4
4.867e-02	-3.02	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	32	ERBB4
4.893e-02	-3.02	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	37	16828	49	CDH20,FBXL7,PON2,CLU,CAMK2G,DTNA,AQP4,LSAMP,NKAIN3,PREX2,NPAS3,ERBB4,SLC1A2,COL5A3,NRXN1,ITPR2,ARHGAP24,SLC1A3,NEBL,GLUL,SFXN5,ATP1A2,CTNND2,HPSE2,ATP13A4,SOX5,NHSL1,PAMR1,ZBTB20,QKI,GPC5,SPARCL1,RYR3,LRIG1,TNIK,RORA,GPM6A
4.924e-02	-3.01	water transmembrane transporter activity	molecular function	GO:0005372	19	1	18094	48	AQP4
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.933e-02	-3.01	parathyroid	COSMIC cancer mutations	parathyroid	476	4	16828	49	RYR3,GPC5,GPM6A,PAMR1
4.941e-02	-3.01	LRR_4	pfam domains	PF12799	18	1	17795	50	LRIG1
4.946e-02	-3.01	EF-hand	gene3d domains	1.10.238.10	272	3	14470	44	DTNA,RYR3,SPARCL1
4.968e-02	-3.00	PTPRA (protein tyrosine phosphatase receptor type A)	protein interactions	5786	139	2	19454	50	CKB,NHSL1
4.968e-02	-3.00	DUSP22 (dual specificity phosphatase 22)	protein interactions	56940	139	2	19454	50	QKI,CTNNA2
4.977e-02	-3.00	DNM1L (dynamin 1 like)	protein interactions	10059	322	3	19454	50	GPM6A,WWOX,CKB
4.987e-02	-3.00	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	2	18094	48	RYR3,ITPR2
4.989e-02	-3.00	CCT7 (chaperonin containing TCP1 subunit 7)	protein interactions	10574	541	4	19454	50	ATP1A2,ARHGAP24,GLUL,WWOX
4.995e-02	-3.00	response to potassium ion	biological process	GO:0035864	19	1	18204	49	ATP1A2
4.995e-02	-3.00	regulation of amyloid-beta clearance	biological process	GO:1900221	19	1	18204	49	CLU
4.995e-02	-3.00	regulation of neurotransmitter uptake	biological process	GO:0051580	19	1	18204	49	ATP1A2
4.995e-02	-3.00	regulation of circadian sleep/wake cycle	biological process	GO:0042749	19	1	18204	49	PTGDS
4.995e-02	-3.00	excitatory synapse assembly	biological process	GO:1904861	19	1	18204	49	NRXN1
4.995e-02	-3.00	cerebellar Purkinje cell layer morphogenesis	biological process	GO:0021692	19	1	18204	49	RORA
4.995e-02	-3.00	microvillus organization	biological process	GO:0032528	19	1	18204	49	TNIK
4.995e-02	-3.00	vascular associated smooth muscle cell differentiation	biological process	GO:0035886	19	1	18204	49	QKI
4.995e-02	-3.00	vocalization behavior	biological process	GO:0071625	19	1	18204	49	NRXN1