Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
6.000e-10	-21.23	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	46	16828	49	SFXN5,CTNND2,MACF1,ZBTB20,SLC1A3,PARD3B,SPARCL1,RFX4,DTNA,SORBS1,NTM,ADCY2,CDH20,PITPNC1,NTRK2,NPAS3,ZNRF3,ATP13A4,SLC1A2,GPM6A,NEBL,PREX2,TRPS1,NRG3,SLC4A4,FBXL7,PTPRZ1,NFIA,ABLIM1,FGFR3,TNIK,NKAIN3,RYR3,GLIS3,GPC5,FMN2,PARD3,RORA,MSI2,HIF3A,LRIG1,NRXN1,SOX5,BMPR1B,NHSL1,LSAMP
8.425e-09	-18.59	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	40	16828	49	PREX2,NEBL,RFX4,PTPRZ1,FBXL7,RANBP3L,NRG3,SLC4A4,TRPS1,MACF1,CTNND2,SLC1A2,ATP13A4,SFXN5,ZNRF3,PARD3B,GPM6A,ZBTB20,ATP1A2,PITPNC1,SOX5,CDH20,HIF3A,LRIG1,NRXN1,LSAMP,NHSL1,SORBS1,FGFR3,TNIK,DTNA,CST3,ABLIM1,PARD3,RORA,ADCY2,FMN2,GPC5,NTM,RYR3
1.500e-08	-18.01	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	17	16828	49	RYR3,ADCY2,PARD3,NFIA,NKAIN3,FGFR3,TNIK,SLC1A2,NRG3,NPAS3,LSAMP,FBXL7,NTRK2,BMPR1B,ATP1A2,PREX2,SOX5
1.500e-08	-18.01	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	17	16828	49	SOX5,PREX2,NTRK2,BMPR1B,ATP1A2,FBXL7,LSAMP,NPAS3,NRG3,FGFR3,TNIK,SLC1A2,NKAIN3,NFIA,ADCY2,PARD3,RYR3
1.540e-08	-17.99	nervous system development	biological process	GO:0007399	2185	22	18204	50	ATP1A2,PREX2,SOX5,NTRK2,CTNNA2,SLC1A3,GPM6A,SLC1A2,BMPR1B,NTM,RORA,LRIG1,LSAMP,MSI2,NRG3,PTPRZ1,NFIA,RFX4,NRXN1,PARD3,CTNND2,TNIK
2.351e-08	-17.57	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	22	16828	49	NPAS3,NHSL1,LSAMP,LRIG1,BMPR1B,NTRK2,SOX5,RYR3,ADCY2,PARD3,FMN2,GPC5,NKAIN3,NRG3,RFX4,FBXL7,PREX2,SLC1A3,GPM6A,SLC1A2,ATP13A4,CTNND2
2.351e-08	-17.57	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	22	16828	49	PREX2,SOX5,BMPR1B,NTRK2,LRIG1,RFX4,FBXL7,LSAMP,NRG3,NHSL1,NPAS3,ATP13A4,SLC1A2,CTNND2,NKAIN3,GPC5,FMN2,GPM6A,PARD3,ADCY2,RYR3,SLC1A3
2.762e-08	-17.40	multicellular organism development	biological process	GO:0007275	3957	29	18204	50	SLC1A2,BMPR1B,ZNRF3,RORA,NTM,GPM6A,RANBP3L,TRPS1,NEBL,PARD3,NRXN1,NFIA,RFX4,CTNND2,TNIK,LRIG1,LSAMP,PTPRZ1,NRG3,MSI2,CDH20,ATP1A2,PREX2,SOX5,HIF3A,SLC1A3,NTRK2,FGFR3,CTNNA2
2.815e-08	-17.39	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	40	16828	49	SFXN5,MACF1,SLC1A2,CTNND2,ATP13A4,SLC1A3,ZBTB20,GPM6A,PARD3B,NEBL,PREX2,NRG3,SLC4A4,TRPS1,PTPRZ1,FBXL7,RFX4,RANBP3L,ABLIM1,NFIA,NKAIN3,SORBS1,TNIK,FGFR3,RYR3,ADCY2,RORA,PARD3,GPC5,NTM,FMN2,GLIS3,NRXN1,LRIG1,NTRK2,SOX5,PITPNC1,NPAS3,NHSL1,LSAMP
2.942e-08	-17.34	plasma membrane	cellular component	GO:0005886	5538	33	19108	49	CST3,ADCY2,GPM6A,DTNA,PARD3B,PREX2,SLC4A4,GPC5,NRXN1,LRIG1,CDH20,FMN2,ATP13A4,PTPRZ1,RYR3,NTM,SORBS1,PARD3,CTNNA2,CTNND2,NTRK2,NRG3,TNIK,MACF1,ZNRF3,SLC1A2,LSAMP,SLC1A3,ATP1A2,NKAIN3,FGFR3,BMPR1B,HIF3A
4.276e-08	-16.97	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	29	16828	49	PREX2,NEBL,PTPRZ1,FBXL7,NRG3,SLC4A4,ATP13A4,CTNND2,SLC1A2,GPM6A,ZBTB20,SLC1A3,SOX5,BMPR1B,NTRK2,NRXN1,HIF3A,LSAMP,TNIK,NKAIN3,NFIA,GLIS3,GPC5,NTM,FMN2,PARD3,ADCY2,RORA,RYR3
4.276e-08	-16.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	29	16828	49	NRG3,SLC4A4,FBXL7,PTPRZ1,NEBL,PREX2,ZBTB20,SLC1A3,GPM6A,ATP13A4,SLC1A2,CTNND2,LSAMP,NRXN1,HIF3A,SOX5,NTRK2,BMPR1B,RYR3,NTM,FMN2,GPC5,GLIS3,RORA,ADCY2,PARD3,NFIA,TNIK,NKAIN3
4.446e-08	-16.93	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	25	16828	49	SLC1A3,GPM6A,PARD3B,SFXN5,ZNRF3,CTNND2,ATP13A4,SLC1A2,NRG3,TRPS1,RFX4,FBXL7,NEBL,PREX2,RYR3,ADCY2,PARD3,FMN2,GPC5,NKAIN3,LSAMP,HIF3A,LRIG1,NTRK2,SOX5
5.055e-08	-16.80	brainstem	COSMIC cancer mutations	brainstem	3102	26	16828	49	GPM6A,ZBTB20,SLC1A3,SLC1A2,ATP13A4,CTNND2,SFXN5,ZNRF3,RANBP3L,FBXL7,PTPRZ1,NRG3,PREX2,FMN2,GPC5,ADCY2,RORA,PARD3,RYR3,TNIK,FGFR3,NKAIN3,LSAMP,NPAS3,SOX5,CDH20
5.314e-08	-16.75	system development	biological process	GO:0048731	3533	27	18204	50	NEBL,PARD3,NRXN1,NFIA,RFX4,CTNND2,TNIK,LRIG1,LSAMP,PTPRZ1,MSI2,NRG3,SLC1A2,BMPR1B,RORA,NTM,GPM6A,TRPS1,RANBP3L,SLC1A3,NTRK2,FGFR3,CTNNA2,ATP1A2,PREX2,SOX5,HIF3A
5.657e-08	-16.69	cell periphery	cellular component	GO:0071944	6020	34	19108	49	PREX2,DTNA,PARD3B,SLC4A4,ADCY2,CST3,GPM6A,FMN2,ATP13A4,PTPRZ1,NTM,RYR3,SORBS1,SPARCL1,CDH20,LRIG1,GPC5,NRXN1,CTNND2,CTNNA2,TNIK,NRG3,NTRK2,PARD3,ATP1A2,FGFR3,NKAIN3,SLC1A3,HIF3A,BMPR1B,MACF1,LSAMP,ZNRF3,SLC1A2
1.027e-07	-16.09	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	24	16828	49	NEBL,PREX2,NRG3,TRPS1,RFX4,FBXL7,SFXN5,ZNRF3,SLC1A2,CTNND2,SLC1A3,GPM6A,PARD3B,LRIG1,HIF3A,NTRK2,SOX5,LSAMP,NKAIN3,RYR3,PARD3,ADCY2,GPC5,FMN2
1.086e-07	-16.04	lymph_node	COSMIC cancer mutations	lymph_node	1703	19	16828	49	ATP13A4,CTNND2,FGFR3,TNIK,SFXN5,DTNA,PARD3B,GPM6A,GPC5,PARD3,RYR3,SLC1A3,SOX5,NTRK2,NEBL,RANBP3L,LSAMP,TRPS1,NRG3
1.173e-07	-15.96	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	23	16828	49	RYR3,ADCY2,PARD3,RORA,FMN2,GPC5,NKAIN3,TNIK,LSAMP,CDH20,SOX5,SLC1A3,ZBTB20,GPM6A,SFXN5,ZNRF3,CTNND2,ATP13A4,NRG3,PTPRZ1,FBXL7,RANBP3L,PREX2
1.201e-07	-15.93	anatomical structure morphogenesis	biological process	GO:0009653	2225	21	18204	50	TNIK,SLC1A3,CTNND2,NFIA,NRXN1,PARD3,NEBL,CDH20,CTNNA2,NRG3,PTPRZ1,FGFR3,LRIG1,NTRK2,SOX5,RORA,BMPR1B,PREX2,ABLIM1,HIF3A,GPM6A
1.245e-07	-15.90	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	9	19454	50	CTNNA2,DTNA,MACF1,NHSL1,PARD3,SORBS1,NEBL,TNIK,ABLIM1
1.813e-07	-15.52	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	13	16828	49	GPC5,PARD3,ADCY2,RYR3,SLC1A2,NKAIN3,FBXL7,LSAMP,NRG3,SOX5,PREX2,ATP1A2,NTRK2
2.064e-07	-15.39	anatomical structure development	biological process	GO:0048856	5207	32	18204	50	SLC1A2,BMPR1B,ZNRF3,RORA,NTM,GPM6A,TRPS1,RANBP3L,ABLIM1,NEBL,RFX4,NFIA,PARD3,NRXN1,CTNND2,FMN2,TNIK,LRIG1,LSAMP,MSI2,NRG3,PTPRZ1,CDH20,ATP1A2,PREX2,SOX5,HIF3A,SLC1A3,FGFR3,NTRK2,CTNNA2,SPARCL1
2.466e-07	-15.22	cell morphogenesis	biological process	GO:0000902	687	12	18204	50	GPM6A,PTPRZ1,CTNNA2,CDH20,PARD3,NRXN1,PREX2,NFIA,CTNND2,BMPR1B,SLC1A3,TNIK
2.811e-07	-15.08	generation of neurons	biological process	GO:0048699	1158	15	18204	50	PARD3,NRXN1,NFIA,TNIK,CTNND2,SLC1A3,NTRK2,PTPRZ1,CTNNA2,PREX2,SOX5,NTM,RORA,BMPR1B,GPM6A
2.894e-07	-15.06	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	11	16828	49	NRG3,LSAMP,SOX5,RYR3,ADCY2,GPC5,FMN2,GPM6A,SFXN5,NKAIN3,CTNND2
3.377e-07	-14.90	mouth	COSMIC cancer mutations	mouth	9004	43	16828	49	NHSL1,LSAMP,LRIG1,NRXN1,HIF3A,SOX5,RYR3,FMN2,GPC5,PARD3,RORA,ABLIM1,CST3,FGFR3,TNIK,TRPS1,SLC4A4,NRG3,RANBP3L,PTPRZ1,FBXL7,NEBL,PREX2,GPM6A,ZNRF3,SLC1A2,ATP13A4,NPAS3,CDH20,PITPNC1,ATP1A2,NTRK2,NTM,ADCY2,DTNA,SORBS1,RFX4,ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1
3.797e-07	-14.78	pharynx	COSMIC cancer mutations	pharynx	2696	23	16828	49	DTNA,NFIA,SORBS1,FGFR3,RYR3,FMN2,GPC5,ATP1A2,NTRK2,PITPNC1,NPAS3,NHSL1,SFXN5,MACF1,CTNND2,SLC1A2,ATP13A4,PARD3B,PREX2,SLC4A4,NRG3,RFX4,PTPRZ1
5.047e-07	-14.50	developmental process	biological process	GO:0032502	5716	33	18204	50	HIF3A,SOX5,ATP1A2,PREX2,CTNNA2,SPARCL1,FGFR3,NTRK2,SLC1A3,ABLIM1,GPM6A,TRPS1,RANBP3L,NHSL1,BMPR1B,RORA,NTM,ZNRF3,SLC1A2,NRG3,MSI2,PTPRZ1,CDH20,LRIG1,LSAMP,FMN2,CTNND2,TNIK,NEBL,RFX4,NFIA,NRXN1,PARD3
5.309e-07	-14.45	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	29	16828	49	SORBS1,TNIK,FGFR3,NFIA,PARD3,ADCY2,NTM,FMN2,RYR3,NTRK2,SOX5,CDH20,LRIG1,HIF3A,NHSL1,MACF1,ATP13A4,CTNND2,PARD3B,GPM6A,ZBTB20,PREX2,RFX4,FBXL7,PTPRZ1,RANBP3L,NRG3,SLC4A4,TRPS1
6.096e-07	-14.31	nodular	COSMIC cancer mutations	nodular	1515	17	16828	49	NPAS3,SLC4A4,SPARCL1,PTPRZ1,CDH20,HIF3A,NEBL,NTRK2,ATP1A2,PREX2,FMN2,GLIS3,ABLIM1,MACF1,FGFR3,CTNND2,ATP13A4
7.801e-07	-14.06	neuron differentiation	biological process	GO:0030182	1081	14	18204	50	GPM6A,PREX2,RORA,NTM,BMPR1B,NTRK2,PTPRZ1,CTNNA2,PARD3,NRXN1,NFIA,TNIK,CTNND2,SLC1A3
9.787e-07	-13.84	cell junction	cellular component	GO:0030054	2224	19	19108	49	NRG3,NTRK2,TNIK,PARD3B,CTNNA2,DTNA,CTNND2,GPM6A,PARD3,SORBS1,PTPRZ1,NFIA,SLC1A3,FGFR3,ATP1A2,SLC1A2,NRXN1,SPARCL1,CDH20
1.216e-06	-13.62	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	28	16828	49	NKAIN3,FGFR3,TNIK,DTNA,ADCY2,RORA,PARD3,GPC5,FMN2,RYR3,ATP1A2,NTRK2,SOX5,CDH20,LSAMP,MACF1,SLC1A2,ATP13A4,CTNND2,GPM6A,SLC1A3,PREX2,NEBL,FBXL7,RANBP3L,NRG3,TRPS1,SPARCL1
1.343e-06	-13.52	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	20	16828	49	PTPRZ1,LSAMP,FBXL7,NRG3,PREX2,SOX5,NTRK2,NEBL,CDH20,GPC5,GPM6A,FMN2,ADCY2,PARD3,RYR3,SLC1A3,FGFR3,CTNND2,SLC1A2,NKAIN3
1.475e-06	-13.43	cerebellum	COSMIC cancer mutations	cerebellum	769	12	16828	49	ABLIM1,CTNND2,RYR3,GPC5,PARD3B,PARD3,NRXN1,NEBL,NTRK2,NRG3,NPAS3,PTPRZ1
1.699e-06	-13.29	neurogenesis	biological process	GO:0022008	1334	15	18204	50	RORA,NTM,SOX5,BMPR1B,PREX2,GPM6A,TNIK,CTNND2,SLC1A3,NFIA,NRXN1,PARD3,CTNNA2,PTPRZ1,NTRK2
1.715e-06	-13.28	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	15	16828	49	CTNND2,ATP13A4,TNIK,FGFR3,MACF1,ABLIM1,GPM6A,NTM,FMN2,ADCY2,RYR3,NTRK2,NEBL,TRPS1,NRG3
1.715e-06	-13.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	15	16828	49	ADCY2,GPM6A,FMN2,NTM,RYR3,MACF1,TNIK,FGFR3,ATP13A4,CTNND2,ABLIM1,NRG3,TRPS1,NTRK2,NEBL
1.826e-06	-13.21	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	45	16828	49	SLC1A2,ATP13A4,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,PTPRZ1,FBXL7,TRPS1,NRG3,SLC4A4,FGFR3,TNIK,NKAIN3,ABLIM1,NFIA,GLIS3,FMN2,GPC5,RORA,PARD3,RYR3,SOX5,BMPR1B,NRXN1,LRIG1,HIF3A,LSAMP,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SORBS1,DTNA,NTM,ADCY2,PITPNC1,ATP1A2,NTRK2,CDH20,NPAS3
1.826e-06	-13.21	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	45	16828	49	RFX4,SFXN5,CTNND2,MACF1,ZBTB20,SLC1A3,PARD3B,CDH20,PITPNC1,NTRK2,ATP1A2,NPAS3,DTNA,SORBS1,NTM,ADCY2,NEBL,PREX2,TRPS1,NRG3,SLC4A4,RANBP3L,PTPRZ1,FBXL7,ZNRF3,ATP13A4,SLC1A2,GPM6A,HIF3A,LRIG1,NRXN1,SOX5,BMPR1B,LSAMP,NFIA,ABLIM1,FGFR3,TNIK,NKAIN3,RYR3,FMN2,GPC5,GLIS3,RORA,PARD3
2.095e-06	-13.08	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	11	16828	49	PTPRZ1,NRG3,NPAS3,NTRK2,NRXN1,NEBL,PARD3,PARD3B,RYR3,CTNND2,ABLIM1
2.127e-06	-13.06	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	11	16828	49	RYR3,NPAS3,NRG3,PARD3B,PARD3,PTPRZ1,ABLIM1,NRXN1,NEBL,CTNND2,NTRK2
2.341e-06	-12.96	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	27	16828	49	ZNRF3,MACF1,CTNND2,SLC1A2,PARD3B,GPM6A,NEBL,PREX2,SLC4A4,TRPS1,RFX4,FBXL7,PTPRZ1,NFIA,FGFR3,TNIK,RYR3,PARD3,ADCY2,GLIS3,FMN2,HIF3A,ATP1A2,NTRK2,PITPNC1,NPAS3,NHSL1
2.609e-06	-12.86	neuron development	biological process	GO:0048666	859	12	18204	50	NRXN1,PARD3,CTNND2,SLC1A3,TNIK,NTRK2,CTNNA2,PTPRZ1,PREX2,BMPR1B,NTM,GPM6A
3.102e-06	-12.68	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	48	16828	49	ADCY2,NTM,DTNA,SORBS1,NPAS3,CDH20,NTRK2,ATP1A2,PITPNC1,SLC1A3,ZBTB20,PARD3B,SFXN5,MACF1,CTNND2,SPARCL1,RFX4,RYR3,RORA,PARD3,FMN2,GPC5,GLIS3,ABLIM1,NFIA,NKAIN3,FGFR3,TNIK,NHSL1,LSAMP,HIF3A,LRIG1,NRXN1,MSI2,BMPR1B,SOX5,GPM6A,ZNRF3,ATP13A4,SLC1A2,SLC4A4,NRG3,TRPS1,FBXL7,PTPRZ1,RANBP3L,NEBL,PREX2
3.130e-06	-12.67	humerus	COSMIC cancer mutations	humerus	546	10	16828	49	ADCY2,GPM6A,GPC5,FMN2,PARD3B,SFXN5,HIF3A,NEBL,NKAIN3,SOX5
3.365e-06	-12.60	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	13	19454	50	PTPRZ1,ATP1A2,SLC4A4,LSAMP,ABLIM1,SORBS1,NHSL1,MSI2,GPM6A,TRPS1,SPARCL1,MACF1,SLC1A3
3.494e-06	-12.56	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	PARD3,ADCY2,RORA,FMN2,GPC5,SLC1A3,RYR3,NKAIN3,CTNND2,LSAMP,FBXL7,NRG3,NTRK2,PREX2,SOX5,NEBL
3.494e-06	-12.56	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	NEBL,NTRK2,SOX5,PREX2,NRG3,LSAMP,FBXL7,NKAIN3,CTNND2,SLC1A3,RYR3,ADCY2,RORA,PARD3,FMN2,GPC5
3.587e-06	-12.54	multicellular organismal process	biological process	GO:0032501	6177	33	18204	50	NTRK2,FGFR3,CTNNA2,SLC1A3,SLC4A4,HIF3A,ATP1A2,PREX2,RYR3,SOX5,LRIG1,LSAMP,PTPRZ1,MSI2,NRG3,CDH20,NEBL,PARD3,NRXN1,RFX4,DTNA,NFIA,CTNND2,TNIK,GPM6A,TRPS1,RANBP3L,ABLIM1,SLC1A2,BMPR1B,RORA,NTM,ZNRF3
3.650e-06	-12.52	MAPT (microtubule associated protein tau)	protein interactions	4137	948	12	19454	50	LSAMP,NEBL,ABLIM1,SORBS1,CTNND2,ATP1A2,TNIK,SLC1A3,NTM,GPM6A,CTNNA2,SLC1A2
5.357e-06	-12.14	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	19	16828	49	CTNND2,SLC1A2,NKAIN3,GPC5,GPM6A,FMN2,ADCY2,PARD3,RYR3,SLC1A3,SOX5,PREX2,NTRK2,NEBL,CDH20,FBXL7,LSAMP,PTPRZ1,NRG3
5.357e-06	-12.14	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	19	16828	49	SLC1A2,CTNND2,NKAIN3,GPC5,GPM6A,FMN2,ADCY2,PARD3,RYR3,SLC1A3,PREX2,SOX5,NTRK2,NEBL,CDH20,LSAMP,FBXL7,PTPRZ1,NRG3
6.057e-06	-12.01	neuron projection morphogenesis	biological process	GO:0048812	486	9	18204	50	BMPR1B,CTNND2,TNIK,PREX2,NRXN1,PARD3,PTPRZ1,CTNNA2,GPM6A
6.186e-06	-11.99	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	47	16828	49	NTRK2,ATP1A2,PITPNC1,CDH20,NPAS3,SORBS1,DTNA,ADCY2,NTM,RFX4,SPARCL1,MACF1,CTNND2,SFXN5,PARD3B,SLC1A3,ZBTB20,BMPR1B,SOX5,LRIG1,HIF3A,NRXN1,LSAMP,NHSL1,FGFR3,TNIK,CST3,ABLIM1,NFIA,PARD3,RORA,GPC5,FMN2,GLIS3,RYR3,PREX2,NEBL,PTPRZ1,FBXL7,RANBP3L,SLC4A4,NRG3,TRPS1,SLC1A2,ATP13A4,ZNRF3,GPM6A
6.276e-06	-11.98	cervix	COSMIC cancer mutations	cervix	11793	47	16828	49	SFXN5,MACF1,CTNND2,SLC1A3,ZBTB20,PARD3B,SPARCL1,RFX4,DTNA,SORBS1,ADCY2,NTM,CDH20,NTRK2,ATP1A2,PITPNC1,NPAS3,ZNRF3,SLC1A2,ATP13A4,GPM6A,NEBL,PREX2,SLC4A4,NRG3,TRPS1,FBXL7,PTPRZ1,RANBP3L,CST3,NFIA,ABLIM1,FGFR3,TNIK,RYR3,RORA,PARD3,GPC5,FMN2,GLIS3,LRIG1,NRXN1,HIF3A,BMPR1B,SOX5,NHSL1,LSAMP
6.578e-06	-11.93	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	9	18204	50	GPM6A,PTPRZ1,CTNNA2,NRXN1,PARD3,PREX2,CTNND2,BMPR1B,TNIK
7.138e-06	-11.85	cell projection morphogenesis	biological process	GO:0048858	496	9	18204	50	CTNNA2,PTPRZ1,GPM6A,CTNND2,BMPR1B,TNIK,PARD3,NRXN1,PREX2
7.143e-06	-11.85	Par3/HAL_N	interpro domains	IPR021922	2	2	18521	50	PARD3B,PARD3
7.428e-06	-11.81	Par3_HAL_N_term	pfam domains	PF12053	2	2	17795	49	PARD3,PARD3B
7.657e-06	-11.78	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	26	16828	49	NPAS3,NTRK2,ATP1A2,PITPNC1,HIF3A,ADCY2,PARD3,FMN2,GLIS3,RYR3,FGFR3,TNIK,NFIA,FBXL7,PTPRZ1,RFX4,SLC4A4,TRPS1,PREX2,NEBL,PARD3B,GPM6A,MACF1,CTNND2,SLC1A2,ZNRF3
7.694e-06	-11.78	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	26	16828	49	SLC4A4,TRPS1,PTPRZ1,FBXL7,RFX4,NEBL,PREX2,GPM6A,PARD3B,ZNRF3,MACF1,SLC1A2,CTNND2,NPAS3,HIF3A,NTRK2,ATP1A2,PITPNC1,RYR3,ADCY2,PARD3,FMN2,GLIS3,NFIA,TNIK,FGFR3
8.240e-06	-11.71	adherens junction	cellular component	GO:0005912	188	6	19108	49	PARD3,CDH20,SORBS1,CTNNA2,PARD3B,CTNND2
1.097e-05	-11.42	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	24	16828	49	PTPRZ1,FBXL7,RANBP3L,NRG3,SLC4A4,PREX2,PARD3B,SLC1A3,MACF1,CTNND2,ZNRF3,LSAMP,NPAS3,NTRK2,BMPR1B,PITPNC1,MSI2,ADCY2,PARD3,FMN2,GPC5,RYR3,TNIK,DTNA
1.097e-05	-11.42	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	24	16828	49	RYR3,FMN2,GPC5,PARD3,ADCY2,DTNA,TNIK,NPAS3,LSAMP,MSI2,PITPNC1,BMPR1B,NTRK2,SLC1A3,PARD3B,ZNRF3,CTNND2,MACF1,SLC4A4,NRG3,RANBP3L,PTPRZ1,FBXL7,PREX2
1.198e-05	-11.33	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	14	16828	49	GLIS3,ABLIM1,MACF1,ATP13A4,CTNND2,NPAS3,SPARCL1,PTPRZ1,CDH20,HIF3A,NEBL,NTRK2,ATP1A2,PREX2
1.251e-05	-11.29	cell junction organization	biological process	GO:0034330	532	9	18204	50	GPM6A,SORBS1,NRG3,SPARCL1,CDH20,NRXN1,PARD3,NFIA,CTNND2
1.332e-05	-11.23	scalp	COSMIC cancer mutations	scalp	2110	18	16828	49	RORA,GPC5,NTM,FMN2,SORBS1,MACF1,ATP13A4,FGFR3,NFIA,LSAMP,PTPRZ1,SLC4A4,TRPS1,ATP1A2,SOX5,PREX2,NEBL,NRXN1
1.412e-05	-11.17	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	36	16828	49	FGFR3,NFIA,CST3,FMN2,NTM,PARD3,RORA,ADCY2,RYR3,SOX5,PITPNC1,NTRK2,ATP1A2,LRIG1,NRXN1,CDH20,LSAMP,NHSL1,NPAS3,ATP13A4,SLC1A2,CTNND2,MACF1,ZNRF3,SFXN5,PARD3B,ZBTB20,PREX2,NEBL,RANBP3L,FBXL7,PTPRZ1,RFX4,TRPS1,NRG3,SLC4A4
1.412e-05	-11.17	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	36	16828	49	SLC1A2,CTNND2,ATP13A4,MACF1,ZNRF3,SFXN5,PARD3B,ZBTB20,PREX2,NEBL,RANBP3L,PTPRZ1,FBXL7,RFX4,TRPS1,NRG3,SLC4A4,FGFR3,NFIA,CST3,NTM,FMN2,PARD3,RORA,ADCY2,RYR3,SOX5,PITPNC1,NTRK2,ATP1A2,NRXN1,LRIG1,CDH20,LSAMP,NPAS3,NHSL1
1.766e-05	-10.94	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	3	19454	50	NRXN1,CST3,CTNND2
1.782e-05	-10.94	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	24	16828	49	CDH20,SOX5,ATP1A2,LSAMP,FGFR3,TNIK,NKAIN3,RYR3,GPC5,FMN2,RORA,ADCY2,PARD3,NEBL,PREX2,SPARCL1,NRG3,RANBP3L,FBXL7,ATP13A4,CTNND2,SLC1A2,MACF1,GPM6A
2.465e-05	-10.61	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	7	16828	49	SOX5,NKAIN3,SFXN5,GPC5,FMN2,GPM6A,ADCY2
2.529e-05	-10.59	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	8	18204	50	PTPRZ1,CTNNA2,NRXN1,PARD3,PREX2,BMPR1B,SLC1A3,CTNND2
2.792e-05	-10.49	Ig_I-set	interpro domains	IPR013098	132	5	18521	50	LSAMP,LRIG1,NTM,NTRK2,FGFR3
2.908e-05	-10.45	bone	COSMIC cancer mutations	bone	8157	38	16828	49	LSAMP,NPAS3,SOX5,ATP1A2,NTRK2,LRIG1,NRXN1,HIF3A,GLIS3,GPC5,FMN2,PARD3,ADCY2,RORA,RYR3,FGFR3,TNIK,SORBS1,NKAIN3,ABLIM1,CST3,DTNA,RANBP3L,PTPRZ1,TRPS1,SPARCL1,SLC4A4,NRG3,PREX2,NEBL,PARD3B,GPM6A,ZBTB20,SLC1A3,ATP13A4,CTNND2,MACF1,SFXN5
3.055e-05	-10.40	I-set	pfam domains	PF07679	132	5	17795	49	LRIG1,FGFR3,NTRK2,NTM,LSAMP
3.641e-05	-10.22	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	14	16828	49	ATP1A2,NTRK2,PITPNC1,PREX2,RFX4,SLC4A4,NHSL1,ATP13A4,CTNND2,SLC1A2,FGFR3,SFXN5,NFIA,FMN2
3.641e-05	-10.22	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	14	16828	49	SLC1A2,ATP13A4,CTNND2,FGFR3,NFIA,SFXN5,FMN2,PITPNC1,PREX2,ATP1A2,NTRK2,RFX4,NHSL1,SLC4A4
3.982e-05	-10.13	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	31	16828	49	SPARCL1,TRPS1,NRG3,FBXL7,PTPRZ1,NEBL,PREX2,SLC1A3,PARD3B,GPM6A,ZNRF3,SLC1A2,CTNND2,MACF1,NHSL1,NPAS3,LSAMP,CDH20,SOX5,NTRK2,RYR3,GLIS3,FMN2,GPC5,ADCY2,PARD3,RORA,NFIA,FGFR3,SORBS1,NKAIN3
4.105e-05	-10.10	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	33	16828	49	NPAS3,ATP1A2,BMPR1B,SOX5,PITPNC1,NRXN1,HIF3A,PARD3,ADCY2,FMN2,GPC5,GLIS3,RYR3,SORBS1,TNIK,FGFR3,ABLIM1,PTPRZ1,FBXL7,RANBP3L,NRG3,SLC4A4,TRPS1,SPARCL1,PREX2,NEBL,GPM6A,PARD3B,ZBTB20,MACF1,ATP13A4,CTNND2,SFXN5
4.274e-05	-10.06	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	28	SLC1A3,SLC1A2
4.274e-05	-10.06	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	28	SLC1A3,SLC1A2
4.861e-05	-9.93	trunk	COSMIC cancer mutations	trunk	3554	23	16828	49	PTPRZ1,SPARCL1,TRPS1,NRG3,PREX2,NEBL,SLC1A3,CTNND2,ATP13A4,MACF1,LSAMP,NPAS3,SOX5,ATP1A2,NTRK2,HIF3A,NRXN1,CDH20,GLIS3,PARD3,RYR3,FGFR3,ABLIM1
6.287e-05	-9.67	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	8	16828	49	CTNND2,ATP13A4,SFXN5,GPM6A,GPC5,LSAMP,RYR3,NRG3
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A3,SLC1A2
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A3,SLC1A2
7.355e-05	-9.52	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	50	SLC1A2,SLC1A3
7.355e-05	-9.52	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	50	SLC1A3,SLC1A2
7.513e-05	-9.50	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	50	SLC1A2,ATP1A2,SLC1A3
7.654e-05	-9.48	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	16	16828	49	ZNRF3,MACF1,TNIK,FGFR3,RYR3,ZBTB20,RORA,FMN2,PARD3B,GPM6A,NRXN1,NEBL,BMPR1B,SOX5,SLC4A4,NPAS3
7.750e-05	-9.47	larynx	COSMIC cancer mutations	larynx	1948	16	16828	49	NRXN1,NEBL,BMPR1B,SOX5,SLC4A4,NPAS3,ZNRF3,MACF1,FGFR3,TNIK,RYR3,ZBTB20,RORA,PARD3B,GPM6A,FMN2
7.798e-05	-9.46	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	30	16828	49	NPAS3,LSAMP,LRIG1,CDH20,SOX5,NTRK2,ATP1A2,RYR3,FMN2,NTM,GPC5,ADCY2,PARD3,CST3,DTNA,NKAIN3,SORBS1,TRPS1,NRG3,SLC4A4,PTPRZ1,FBXL7,NEBL,SLC1A3,PARD3B,GPM6A,ZNRF3,ATP13A4,CTNND2,MACF1
7.798e-05	-9.46	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	30	16828	49	LSAMP,NPAS3,SOX5,NTRK2,ATP1A2,LRIG1,CDH20,FMN2,NTM,GPC5,PARD3,ADCY2,RYR3,NKAIN3,SORBS1,DTNA,CST3,PTPRZ1,FBXL7,TRPS1,NRG3,SLC4A4,NEBL,GPM6A,PARD3B,SLC1A3,ATP13A4,CTNND2,MACF1,ZNRF3
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	NTM,GPM6A,LSAMP
8.705e-05	-9.35	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	31	16828	49	FGFR3,SORBS1,NFIA,ABLIM1,DTNA,GLIS3,FMN2,GPC5,ADCY2,PARD3,ATP1A2,NTRK2,LRIG1,NRXN1,HIF3A,CDH20,ATP13A4,MACF1,SFXN5,GPM6A,PARD3B,ZBTB20,SLC1A3,PREX2,NEBL,RFX4,PTPRZ1,SPARCL1,TRPS1,NRG3,SLC4A4
8.767e-05	-9.34	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	31	16828	49	CDH20,LRIG1,HIF3A,NRXN1,ATP1A2,NTRK2,PARD3,ADCY2,GLIS3,FMN2,GPC5,DTNA,ABLIM1,NFIA,SORBS1,FGFR3,NRG3,SLC4A4,SPARCL1,TRPS1,RFX4,PTPRZ1,NEBL,PREX2,SLC1A3,ZBTB20,GPM6A,PARD3B,SFXN5,MACF1,ATP13A4
9.059e-05	-9.31	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	50	ATP1A2,SLC1A2,SLC4A4,SLC1A3
9.059e-05	-9.31	vascular transport	biological process	GO:0010232	86	4	18204	50	SLC1A3,SLC4A4,SLC1A2,ATP1A2
9.079e-05	-9.31	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	48	16828	49	RFX4,SFXN5,CTNND2,MACF1,ZBTB20,SLC1A3,PARD3B,CDH20,PITPNC1,ATP1A2,NTRK2,NPAS3,DTNA,SORBS1,NTM,ADCY2,NEBL,PREX2,TRPS1,SLC4A4,NRG3,RANBP3L,PTPRZ1,FBXL7,ZNRF3,ATP13A4,SLC1A2,GPM6A,MSI2,NRXN1,HIF3A,LRIG1,SOX5,BMPR1B,NHSL1,LSAMP,NFIA,ABLIM1,CST3,TNIK,FGFR3,NKAIN3,RYR3,GLIS3,FMN2,GPC5,PARD3,RORA
9.692e-05	-9.24	Salivary secretion	KEGG pathways	hsa04970	90	4	7161	20	ADCY2,RYR3,ATP1A2,CST3
9.692e-05	-9.24	Salivary secretion	KEGG pathways	ko04970	90	4	7161	20	RYR3,CST3,ATP1A2,ADCY2
9.850e-05	-9.23	neuron projection development	biological process	GO:0031175	693	9	18204	50	CTNND2,BMPR1B,TNIK,PARD3,PREX2,NRXN1,CTNNA2,PTPRZ1,GPM6A
1.004e-04	-9.21	response to auditory stimulus	biological process	GO:0010996	33	3	18204	50	ATP1A2,NRXN1,SLC1A3
1.101e-04	-9.11	D-amino acid transport	biological process	GO:0042940	6	2	18204	50	SLC1A3,SLC1A2
1.101e-04	-9.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	50	SLC1A2,SLC1A3
1.167e-04	-9.06	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	4	19454	50	FGFR3,NTRK2,PARD3,SORBS1
1.219e-04	-9.01	tibia	COSMIC cancer mutations	tibia	836	10	16828	49	RANBP3L,GPM6A,LSAMP,TNIK,PREX2,FGFR3,CTNND2,MACF1,NKAIN3,ABLIM1
1.245e-04	-8.99	cell junction assembly	biological process	GO:0034329	285	6	18204	50	NRG3,CDH20,SORBS1,GPM6A,PARD3,NRXN1
1.317e-04	-8.94	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	16	16828	49	MACF1,FGFR3,ZNRF3,ABLIM1,PARD3,RORA,GPC5,GPM6A,FMN2,PREX2,NEBL,MSI2,PTPRZ1,LSAMP,NRG3,TRPS1
1.374e-04	-8.89	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	6	19454	50	ABLIM1,TNIK,FMN2,DTNA,PARD3,MACF1
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.490e-04	-8.81	FLOT1 (flotillin 1)	protein interactions	10211	453	7	19454	50	DTNA,FMN2,SOX5,MACF1,PARD3,SORBS1,ABLIM1
1.546e-04	-8.77	SDF	pfam domains	PF00375	7	2	17795	49	SLC1A2,SLC1A3
1.662e-04	-8.70	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	50	SLC1A2,SLC1A3,RYR3
1.810e-04	-8.62	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	41	16828	49	RYR3,RORA,PARD3,NTM,FMN2,GPC5,CST3,DTNA,NFIA,ABLIM1,NKAIN3,SORBS1,FGFR3,TNIK,NPAS3,CDH20,LRIG1,NRXN1,HIF3A,MSI2,NTRK2,ATP1A2,BMPR1B,SOX5,PITPNC1,PARD3B,GPM6A,ZNRF3,MACF1,ATP13A4,CTNND2,NRG3,SLC4A4,SPARCL1,TRPS1,PTPRZ1,FBXL7,RFX4,RANBP3L,NEBL,PREX2
1.838e-04	-8.60	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	41	16828	49	PREX2,NEBL,RFX4,PTPRZ1,FBXL7,RANBP3L,SLC4A4,NRG3,SPARCL1,TRPS1,MACF1,ATP13A4,CTNND2,ZNRF3,GPM6A,PARD3B,ATP1A2,BMPR1B,NTRK2,PITPNC1,SOX5,CDH20,MSI2,LRIG1,NRXN1,HIF3A,NPAS3,SORBS1,NKAIN3,TNIK,FGFR3,CST3,DTNA,ABLIM1,NFIA,RORA,PARD3,FMN2,NTM,GPC5,RYR3
1.841e-04	-8.60	beta-catenin binding	molecular function	GO:0008013	107	4	18094	48	CTNNA2,CTNND2,CDH20,RORA
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	LSAMP,NKAIN3,CTNND2,GPM6A
1.879e-04	-8.58	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	44	SLC1A2,SLC1A3
2.037e-04	-8.50	cell adhesion	biological process	GO:0007155	942	10	18204	50	CTNND2,NTM,NRXN1,PARD3,SPARCL1,CTNNA2,CDH20,SORBS1,LSAMP,PARD3B
2.059e-04	-8.49	cell development	biological process	GO:0048468	2236	16	18204	50	PTPRZ1,CTNNA2,MSI2,NTRK2,TNIK,FMN2,CTNND2,SLC1A3,PARD3,NRXN1,NEBL,GPM6A,RORA,NTM,BMPR1B,PREX2
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	LSAMP,NTM
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.355e-04	-8.35	face	COSMIC cancer mutations	face	2139	16	16828	49	NEBL,MSI2,PREX2,NRG3,TRPS1,LSAMP,PTPRZ1,ZNRF3,ABLIM1,MACF1,FGFR3,PARD3,RORA,FMN2,GPM6A,GPC5
2.357e-04	-8.35	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	11	18204	50	TNIK,BMPR1B,CTNND2,RFX4,NRXN1,PARD3,PREX2,ABLIM1,CTNNA2,PTPRZ1,GPM6A
2.551e-04	-8.27	acidic amino acid transport	biological process	GO:0015800	45	3	18204	50	SLC1A3,SLC1A2,NTRK2
2.564e-04	-8.27	OCLN (occludin)	protein interactions	100506658	495	7	19454	50	NTRK2,DTNA,FMN2,ABLIM1,TNIK,PARD3,MACF1
2.601e-04	-8.25	EDTRNSPORT	prints domains	PR00173	7	2	5227	19	SLC1A3,SLC1A2
2.655e-04	-8.23	synapse	cellular component	GO:0045202	1473	12	19108	49	GPM6A,NRG3,NTRK2,TNIK,DTNA,CTNND2,SLC1A2,NRXN1,SPARCL1,PTPRZ1,SLC1A3,ATP1A2
2.680e-04	-8.22	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	9	16828	49	SLC1A3,TRPS1,PARD3,RANBP3L,DTNA,NEBL,NTRK2,SOX5,CTNND2
2.767e-04	-8.19	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	45	SLC1A3,SLC1A2
2.767e-04	-8.19	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	45	SLC1A3,SLC1A2
2.833e-04	-8.17	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	35	16828	49	RANBP3L,RFX4,FBXL7,PTPRZ1,TRPS1,NRG3,SLC4A4,PREX2,NEBL,GPM6A,SLC1A3,SLC1A2,ATP13A4,CTNND2,MACF1,SFXN5,LSAMP,NHSL1,SOX5,BMPR1B,ATP1A2,NTRK2,LRIG1,CDH20,GLIS3,GPC5,FMN2,PARD3,RORA,ADCY2,RYR3,FGFR3,TNIK,NKAIN3,ABLIM1
2.864e-04	-8.16	SFN (stratifin)	protein interactions	2810	671	8	19454	50	FMN2,PARD3B,TNIK,NFIA,ABLIM1,MACF1,PARD3,SORBS1
2.889e-04	-8.15	synapse organization	biological process	GO:0050808	333	6	18204	50	GPM6A,SPARCL1,NRG3,NRXN1,NFIA,CTNND2
3.121e-04	-8.07	cell-cell junction	cellular component	GO:0005911	513	7	19108	49	PARD3B,CTNNA2,CTNND2,ATP1A2,SORBS1,PARD3,CDH20
3.155e-04	-8.06	plasma membrane region	cellular component	GO:0098590	1278	11	19108	49	SLC4A4,TNIK,PARD3B,GPM6A,PARD3,SORBS1,SLC1A3,ATP1A2,SLC1A2,NRXN1,MACF1
3.162e-04	-8.06	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	4	19454	50	PARD3,MACF1,ABLIM1,DTNA
3.165e-04	-8.06	central nervous system development	biological process	GO:0007417	995	10	18204	50	RORA,BMPR1B,SLC1A2,RFX4,ATP1A2,PTPRZ1,NRG3,CTNNA2,MSI2,NTRK2
3.195e-04	-8.05	cell differentiation	biological process	GO:0030154	3645	21	18204	50	PREX2,BMPR1B,NHSL1,SOX5,NTM,RORA,GPM6A,RANBP3L,NEBL,PARD3,NRXN1,NFIA,CTNND2,SLC1A3,FMN2,TNIK,NTRK2,FGFR3,PTPRZ1,MSI2,CTNNA2
3.233e-04	-8.04	cellular developmental process	biological process	GO:0048869	3648	21	18204	50	PTPRZ1,CTNNA2,MSI2,NTRK2,FGFR3,TNIK,FMN2,CTNND2,SLC1A3,PARD3,NRXN1,NFIA,NEBL,RANBP3L,GPM6A,SOX5,RORA,NTM,BMPR1B,NHSL1,PREX2
3.281e-04	-8.02	action potential propagation	biological process	GO:0098870	10	2	18204	50	ATP1A2,NTRK2
3.281e-04	-8.02	cellular response to cocaine	biological process	GO:0071314	10	2	18204	50	SLC1A3,SLC1A2
3.281e-04	-8.02	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	50	NTRK2,ATP1A2
3.281e-04	-8.02	establishment of centrosome localization	biological process	GO:0051660	10	2	18204	50	PARD3B,PARD3
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	SLC1A2,PREX2,SOX5,RYR3
3.355e-04	-8.00	cell projection organization	biological process	GO:0030030	1200	11	18204	50	RFX4,PREX2,PARD3,NRXN1,TNIK,CTNND2,BMPR1B,GPM6A,ABLIM1,CTNNA2,PTPRZ1
3.988e-04	-7.83	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	4	19454	50	DTNA,NTRK2,ABLIM1,PARD3
4.003e-04	-7.82	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	50	SLC1A3,SLC1A2
4.003e-04	-7.82	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	50	SLC1A2,SLC1A3
4.026e-04	-7.82	leg	COSMIC cancer mutations	leg	969	10	16828	49	NEBL,HIF3A,FGFR3,ATP13A4,ZBTB20,SLC4A4,NRG3,FMN2,NTM,PTPRZ1
4.146e-04	-7.79	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	50	SOX5,BMPR1B,TRPS1
4.301e-04	-7.75	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	50	MSI2,DTNA,FMN2,MACF1,PARD3,SLC1A3,TNIK,ABLIM1
4.439e-04	-7.72	NAKATPASE	prints domains	PR00121	9	2	5227	19	ATP13A4,ATP1A2
4.465e-04	-7.71	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	21	16828	49	MACF1,CTNND2,TNIK,ABLIM1,PARD3,ADCY2,GPC5,GPM6A,FMN2,RYR3,ZBTB20,ATP1A2,PREX2,SOX5,NEBL,LRIG1,PTPRZ1,NHSL1,SLC4A4,NRG3,SPARCL1
4.466e-04	-7.71	neuron projection	cellular component	GO:0043005	1331	11	19108	49	DTNA,CTNNA2,CTNND2,NTRK2,PARD3,ADCY2,GPM6A,SLC1A3,ATP1A2,BMPR1B,SLC1A2
4.501e-04	-7.71	middle_third	COSMIC cancer mutations	middle_third	3533	21	16828	49	RYR3,ZBTB20,PARD3,ADCY2,FMN2,GPC5,GPM6A,ABLIM1,MACF1,CTNND2,TNIK,NRG3,NHSL1,SLC4A4,SPARCL1,PTPRZ1,NEBL,LRIG1,ATP1A2,SOX5,PREX2
4.529e-04	-7.70	Ig_sub2	interpro domains	IPR003598	239	5	18521	50	FGFR3,LSAMP,LRIG1,NTRK2,NTM
4.698e-04	-7.66	amino acid transport	biological process	GO:0006865	132	4	18204	50	SLC1A3,NTRK2,SLC1A2,SFXN5
4.795e-04	-7.64	auditory behavior	biological process	GO:0031223	12	2	18204	50	SLC1A3,NRXN1
5.060e-04	-7.59	cell body	cellular component	GO:0044297	556	7	19108	49	NRXN1,GPM6A,SLC1A2,CTNND2,ATP1A2,SLC1A3,BMPR1B
5.787e-04	-7.45	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	11	16828	49	NKAIN3,SOX5,TNIK,CTNND2,NRG3,RORA,LSAMP,PARD3,ADCY2,RANBP3L,GPC5
5.865e-04	-7.44	neurotransmitter transport	biological process	GO:0006836	140	4	18204	50	SLC1A2,NRXN1,ATP1A2,SLC1A3
6.069e-04	-7.41	Ig_3	pfam domains	PF13927	141	4	17795	49	LSAMP,NTM,FGFR3,LRIG1
6.143e-04	-7.40	gallbladder	COSMIC cancer mutations	gallbladder	2821	18	16828	49	PITPNC1,PREX2,LRIG1,PTPRZ1,SPARCL1,TRPS1,NHSL1,NRG3,SLC4A4,CTNND2,TNIK,FGFR3,MACF1,NKAIN3,ZNRF3,FMN2,PARD3,RYR3
6.143e-04	-7.40	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	18	16828	49	LRIG1,PREX2,PITPNC1,NRG3,SLC4A4,NHSL1,TRPS1,SPARCL1,PTPRZ1,ZNRF3,NKAIN3,MACF1,FGFR3,TNIK,CTNND2,RYR3,PARD3,FMN2
6.144e-04	-7.39	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	33	16828	49	GPM6A,PARD3B,SLC1A3,MACF1,ATP13A4,CTNND2,SLC1A2,SFXN5,RFX4,PTPRZ1,FBXL7,RANBP3L,NRG3,SPARCL1,PREX2,NEBL,ADCY2,RORA,PARD3,GLIS3,GPC5,FMN2,RYR3,NKAIN3,TNIK,ABLIM1,LSAMP,NHSL1,BMPR1B,NTRK2,SOX5,CDH20,LRIG1
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A2,SLC1A3
6.388e-04	-7.36	CDH1 (cadherin 1)	protein interactions	999	757	8	19454	50	CTNNA2,CTNND2,MACF1,PARD3,SORBS1,NHSL1,NEBL,ABLIM1
6.588e-04	-7.33	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	50	SLC4A4,ATP1A2
6.588e-04	-7.33	mechanosensory behavior	biological process	GO:0007638	14	2	18204	50	SLC1A3,NRXN1
6.654e-04	-7.32	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	2	19454	50	TNIK,PARD3
6.866e-04	-7.28	adult behavior	biological process	GO:0030534	146	4	18204	50	ATP1A2,PREX2,SLC1A2,NRXN1
6.932e-04	-7.27	cell projection	cellular component	GO:0042995	2398	15	19108	49	CTNNA2,DTNA,CTNND2,NTRK2,PARD3,ADCY2,GPM6A,ABLIM1,SLC1A3,ATP1A2,FMN2,BMPR1B,NRXN1,MACF1,SLC1A2
7.080e-04	-7.25	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	4	16828	49	PARD3,FGFR3,GPC5,NRG3
7.220e-04	-7.23	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	50	PREX2,CTNNA2,CTNND2
7.405e-04	-7.21	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	8	18094	48	ATP1A2,SLC1A2,SFXN5,SLC4A4,GPM6A,SLC1A3,ATP13A4,RYR3
7.502e-04	-7.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	5	16828	49	NFIA,NRG3,NPAS3,GPC5,ADCY2
7.502e-04	-7.20	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	5	16828	49	NFIA,NRG3,NPAS3,GPC5,ADCY2
7.721e-04	-7.17	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	5	18094	48	SLC4A4,SLC1A3,ATP13A4,SLC1A2,ATP1A2
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	SLC1A2,ATP1A2,SLC4A4,SLC1A3
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	ZBTB20,LSAMP
8.309e-04	-7.09	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	5	19454	50	NTRK2,DTNA,PARD3B,PARD3,SORBS1
8.440e-04	-7.08	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	5	19454	50	NHSL1,SORBS1,PARD3,FMN2,NEBL
8.657e-04	-7.05	asymmetric cell division	biological process	GO:0008356	16	2	18204	50	PARD3,SOX5
8.795e-04	-7.04	retina development in camera-type eye	biological process	GO:0060041	156	4	18204	50	GPM6A,NTRK2,NFIA,BMPR1B
8.890e-04	-7.03	cellular response to endogenous stimulus	biological process	GO:0071495	1135	10	18204	50	BMPR1B,SLC1A3,SOX5,RYR3,ATP1A2,NFIA,SLC1A2,SORBS1,FGFR3,NTRK2
8.898e-04	-7.02	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	33	16828	49	CST3,DTNA,ABLIM1,NKAIN3,SORBS1,FGFR3,TNIK,RYR3,ADCY2,RORA,PARD3,FMN2,GLIS3,LRIG1,NRXN1,HIF3A,NTRK2,ATP1A2,SOX5,NPAS3,MACF1,ATP13A4,CTNND2,SLC1A3,ZBTB20,PARD3B,NEBL,PREX2,NRG3,SLC4A4,SPARCL1,TRPS1,PTPRZ1
8.949e-04	-7.02	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	30	16828	49	HIF3A,CDH20,PITPNC1,SOX5,NHSL1,NPAS3,ABLIM1,FGFR3,SORBS1,RYR3,GPC5,FMN2,NTM,PARD3,ADCY2,RORA,PREX2,TRPS1,SLC4A4,NRG3,RFX4,FBXL7,SFXN5,SLC1A2,CTNND2,MACF1,ZBTB20,SLC1A3,GPM6A,PARD3B
9.010e-04	-7.01	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	12	16828	49	DTNA,FGFR3,SORBS1,MACF1,RYR3,GPC5,FMN2,PARD3B,PREX2,NRG3,NPAS3,PTPRZ1
9.072e-04	-7.01	prostate	COSMIC cancer mutations	prostate	13883	48	16828	49	CDH20,NTRK2,ATP1A2,PITPNC1,NPAS3,DTNA,SORBS1,ADCY2,NTM,SPARCL1,RFX4,SFXN5,MACF1,CTNND2,SLC1A3,ZBTB20,PARD3B,LRIG1,HIF3A,NRXN1,MSI2,BMPR1B,SOX5,NHSL1,LSAMP,ABLIM1,NFIA,NKAIN3,TNIK,FGFR3,RYR3,PARD3,RORA,GPC5,FMN2,GLIS3,NEBL,PREX2,SLC4A4,NRG3,TRPS1,FBXL7,PTPRZ1,RANBP3L,ZNRF3,SLC1A2,ATP13A4,GPM6A
9.296e-04	-6.98	alveolar	COSMIC cancer mutations	alveolar	2414	16	16828	49	PREX2,CDH20,NHSL1,NPAS3,TRPS1,SPARCL1,MACF1,SORBS1,FGFR3,ZNRF3,NFIA,PARD3,PARD3B,FMN2,SLC1A3,RYR3
9.296e-04	-6.98	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	16	16828	49	NPAS3,NHSL1,SPARCL1,TRPS1,CDH20,PREX2,SLC1A3,RYR3,PARD3,PARD3B,FMN2,ZNRF3,NFIA,MACF1,SORBS1,FGFR3
9.374e-04	-6.97	telencephalon development	biological process	GO:0021537	276	5	18204	50	NRG3,RFX4,SLC1A2,ATP1A2,NTRK2
9.435e-04	-6.97	Bile secretion	KEGG pathways	hsa04976	71	3	7161	20	ATP1A2,SLC4A4,ADCY2
9.435e-04	-6.97	Bile secretion	KEGG pathways	ko04976	71	3	7161	20	ATP1A2,SLC4A4,ADCY2
9.623e-04	-6.95	actin binding	molecular function	GO:0003779	434	6	18094	48	CTNNA2,ABLIM1,MACF1,FMN2,NEBL,SORBS1
9.648e-04	-6.94	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	2	19454	50	PARD3,FGFR3
9.763e-04	-6.93	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	5	16828	49	RYR3,SLC1A2,SOX5,PREX2,FGFR3
9.828e-04	-6.93	Adherens junction	KEGG pathways	hsa04520	72	3	7161	20	SORBS1,CTNNA2,PARD3
9.828e-04	-6.93	Adherens junction	KEGG pathways	ko04520	72	3	7161	20	SORBS1,CTNNA2,PARD3
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	NTM,LSAMP,GPM6A
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A2,SLC1A3
1.057e-03	-6.85	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	6	18094	48	SLC1A2,GPM6A,ATP1A2,SLC4A4,RYR3,SLC1A3
1.059e-03	-6.85	regulation of cartilage development	biological process	GO:0061035	73	3	18204	50	TRPS1,BMPR1B,SOX5
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP13A4,ATP1A2
1.066e-03	-6.84	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	7	16828	49	ADCY2,FBXL7,TRPS1,RYR3,SLC4A4,CTNND2,NTRK2
1.089e-03	-6.82	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	7	16828	49	NTRK2,CTNND2,FBXL7,ADCY2,SLC4A4,RYR3,TRPS1
1.105e-03	-6.81	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	49	ATP1A2,ATP13A4
1.134e-03	-6.78	spleen	COSMIC cancer mutations	spleen	408	6	16828	49	TNIK,SORBS1,PARD3B,NTM,ADCY2,PTPRZ1
1.155e-03	-6.76	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	5	19454	50	MACF1,SORBS1,PARD3,DTNA,NRXN1
1.179e-03	-6.74	RHOB (ras homolog family member B)	protein interactions	388	832	8	19454	50	PARD3,SLC1A3,MACF1,ABLIM1,TNIK,PARD3B,FMN2,DTNA
1.186e-03	-6.74	PAS_fold	interpro domains	IPR013767	19	2	18521	50	NPAS3,HIF3A
1.215e-03	-6.71	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	10	16828	49	CDH20,SLC1A2,ATP13A4,SOX5,RYR3,NRG3,GPC5,FMN2,PARD3,ADCY2
1.226e-03	-6.70	GSC (goosecoid homeobox)	protein interactions	145258	82	3	19454	50	SOX5,TRPS1,NFIA
1.227e-03	-6.70	cartilage condensation	biological process	GO:0001502	19	2	18204	50	SOX5,BMPR1B
1.233e-03	-6.70	PAS	pfam domains	PF00989	19	2	17795	49	NPAS3,HIF3A
1.246e-03	-6.69	somatodendritic compartment	cellular component	GO:0036477	842	8	19108	49	ADCY2,NRXN1,GPM6A,CTNND2,ATP1A2,SLC1A3,BMPR1B,NTRK2
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC1A2,SLC1A3,SLC4A4
1.277e-03	-6.66	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	7	18094	48	GPM6A,ATP13A4,SLC1A3,RYR3,ATP1A2,SLC1A2,SLC4A4
1.283e-03	-6.66	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	3	18204	50	SLC4A4,SORBS1,ZBTB20
1.283e-03	-6.66	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	50	NTRK2,SLC1A2,SLC1A3
1.290e-03	-6.65	cartilage development	biological process	GO:0051216	173	4	18204	50	NFIA,FGFR3,SOX5,BMPR1B
1.293e-03	-6.65	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	3	18094	48	NTRK2,FGFR3,BMPR1B
1.295e-03	-6.65	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	23	16828	49	FGFR3,CTNND2,MACF1,ABLIM1,ZNRF3,DTNA,GPM6A,FMN2,GLIS3,ADCY2,PARD3,RYR3,SLC1A3,SOX5,PREX2,ATP1A2,HIF3A,RANBP3L,PTPRZ1,RFX4,TRPS1,NHSL1,NRG3
1.295e-03	-6.65	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	23	16828	49	ATP1A2,SOX5,PREX2,HIF3A,PTPRZ1,RFX4,RANBP3L,NHSL1,NRG3,TRPS1,MACF1,FGFR3,CTNND2,ZNRF3,DTNA,ABLIM1,ADCY2,PARD3,GPM6A,FMN2,GLIS3,SLC1A3,RYR3
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	SORBS1,MACF1
1.332e-03	-6.62	mucosal	COSMIC cancer mutations	mucosal	2009	14	16828	49	SPARCL1,NRG3,PREX2,ATP1A2,BMPR1B,NEBL,FMN2,PARD3,RORA,FGFR3,CTNND2,ATP13A4,SORBS1,ABLIM1
1.332e-03	-6.62	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	14	16828	49	NEBL,ATP1A2,BMPR1B,PREX2,NRG3,SPARCL1,ABLIM1,SORBS1,FGFR3,ATP13A4,CTNND2,RORA,PARD3,FMN2
1.357e-03	-6.60	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	14	19108	49	ADCY2,PARD3,GPM6A,ABLIM1,CTNND2,CTNNA2,DTNA,NTRK2,MACF1,SLC1A2,ATP1A2,FMN2,SLC1A3,BMPR1B
1.361e-03	-6.60	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	50	BMPR1B,SOX5
1.361e-03	-6.60	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	50	SLC1A3,SLC1A2
1.397e-03	-6.57	stress fiber	cellular component	GO:0001725	86	3	19108	49	ABLIM1,NEBL,SORBS1
1.397e-03	-6.57	contractile actin filament bundle	cellular component	GO:0097517	86	3	19108	49	NEBL,ABLIM1,SORBS1
1.398e-03	-6.57	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	32	16828	49	GLIS3,GPC5,FMN2,ADCY2,PARD3,RORA,RYR3,FGFR3,NKAIN3,ABLIM1,LSAMP,NHSL1,SOX5,BMPR1B,ATP1A2,NTRK2,LRIG1,CDH20,GPM6A,SLC1A3,ATP13A4,CTNND2,SLC1A2,MACF1,SFXN5,RANBP3L,RFX4,FBXL7,NRG3,SLC4A4,PREX2,NEBL
1.425e-03	-6.55	behavior	biological process	GO:0007610	619	7	18204	50	NTRK2,PTPRZ1,ATP1A2,NRXN1,SLC1A2,PREX2,SLC1A3
1.439e-03	-6.54	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	22	16828	49	LSAMP,SOX5,ATP1A2,NRXN1,HIF3A,LRIG1,GPC5,GLIS3,PARD3,ADCY2,RYR3,TNIK,FGFR3,NFIA,DTNA,PTPRZ1,TRPS1,SPARCL1,CTNND2,ATP13A4,MACF1,ZNRF3
1.446e-03	-6.54	monoatomic ion transmembrane transport	biological process	GO:0034220	804	8	18204	50	SLC4A4,SLC1A3,RYR3,ATP1A2,SFXN5,SLC1A2,ATP13A4,GPM6A
1.499e-03	-6.50	neuronal cell body	cellular component	GO:0043025	489	6	19108	49	ATP1A2,CTNND2,SLC1A3,BMPR1B,NRXN1,GPM6A
1.502e-03	-6.50	positive regulation of nucleotide catabolic process	biological process	GO:0030813	21	2	18204	50	SLC4A4,ZBTB20
1.502e-03	-6.50	cell aggregation	biological process	GO:0098743	21	2	18204	50	BMPR1B,SOX5
1.502e-03	-6.50	positive regulation of glycolytic process	biological process	GO:0045821	21	2	18204	50	ZBTB20,SLC4A4
1.502e-03	-6.50	positive regulation of purine nucleotide catabolic process	biological process	GO:0033123	21	2	18204	50	SLC4A4,ZBTB20
1.563e-03	-6.46	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	42	16828	49	SFXN5,MACF1,ATP13A4,CTNND2,SLC1A2,SLC1A3,PARD3B,NEBL,PREX2,NRG3,SLC4A4,SPARCL1,RFX4,PTPRZ1,FBXL7,RANBP3L,DTNA,NFIA,ABLIM1,NKAIN3,TNIK,FGFR3,RYR3,RORA,ADCY2,PARD3,GLIS3,GPC5,FMN2,NTM,CDH20,MSI2,NRXN1,HIF3A,LRIG1,ATP1A2,BMPR1B,NTRK2,SOX5,NPAS3,NHSL1,LSAMP
1.587e-03	-6.45	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	4	18204	50	SORBS1,ZBTB20,SLC4A4,RORA
1.594e-03	-6.44	DEP_dom	interpro domains	IPR000591	22	2	18521	50	PREX2,FMN2
1.632e-03	-6.42	cellular response to organic cyclic compound	biological process	GO:0071407	464	6	18204	50	SLC1A2,ADCY2,ATP1A2,RYR3,RORA,SLC1A3
1.644e-03	-6.41	chondrocyte differentiation	biological process	GO:0002062	85	3	18204	50	BMPR1B,SOX5,FGFR3
1.649e-03	-6.41	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	50	ATP1A2,SLC1A3
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A2,SLC1A3
1.689e-03	-6.38	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	12	16828	49	SOX5,ATP1A2,NRXN1,LSAMP,PTPRZ1,TRPS1,SLC4A4,FGFR3,ATP13A4,MACF1,GPC5,RORA
1.695e-03	-6.38	actomyosin	cellular component	GO:0042641	92	3	19108	49	SORBS1,ABLIM1,NEBL
1.715e-03	-6.37	human chr5p13.2	chromosome location	human chr5p13.2	32	2	26134	50	RANBP3L,SLC1A3
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	RYR3,ATP1A2,PARD3,DTNA
1.781e-03	-6.33	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	49	LSAMP,NHSL1,NPAS3,NTRK2,BMPR1B,ATP1A2,SOX5,CDH20,NRXN1,LRIG1,MSI2,ADCY2,PARD3,RORA,FMN2,NTM,GPC5,GLIS3,RYR3,SORBS1,TNIK,FGFR3,DTNA,CST3,PTPRZ1,FBXL7,RANBP3L,SLC4A4,NRG3,TRPS1,PREX2,NEBL,PARD3B,SLC1A3,ZBTB20,MACF1,SLC1A2,CTNND2,ATP13A4,ZNRF3,SFXN5
1.810e-03	-6.31	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	20	SLC4A4,ATP1A2
1.810e-03	-6.31	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	20	ATP1A2,SLC4A4
1.815e-03	-6.31	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	7	10285	28	SLC1A3,SLC1A2,SLC4A4,ATP1A2,ADCY2,RYR3,ATP13A4
1.818e-03	-6.31	Cation_ATPase_N	smart domains	SM00831	16	2	9717	39	ATP1A2,ATP13A4
1.832e-03	-6.30	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	48	ATP13A4,ATP1A2
1.832e-03	-6.30	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	48	ATP1A2,ATP13A4
1.854e-03	-6.29	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	4	19454	50	DTNA,PARD3B,ABLIM1,NRXN1
1.866e-03	-6.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	9	16828	49	NRG3,GPC5,ADCY2,RORA,LSAMP,PARD3,CTNND2,SOX5,NKAIN3
1.901e-03	-6.27	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	28	SLC1A2,SLC1A3
1.909e-03	-6.26	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	12	16828	49	PTPRZ1,RORA,PARD3B,FMN2,MACF1,SORBS1,FGFR3,PREX2,CTNND2,CDH20,DTNA,ABLIM1
1.909e-03	-6.26	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	12	16828	49	PREX2,CDH20,PTPRZ1,CTNND2,FGFR3,SORBS1,MACF1,ABLIM1,DTNA,FMN2,PARD3B,RORA
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr10p11.22-p11.21	chromosome location	human chr10p11.22-p11.21	1	1	26134	50	PARD3
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.915e-03	-6.26	actin filament bundle	cellular component	GO:0032432	96	3	19108	49	SORBS1,ABLIM1,NEBL
1.928e-03	-6.25	anchoring junction	cellular component	GO:0070161	902	8	19108	49	CDH20,PARD3,FGFR3,ATP1A2,CTNND2,PARD3B,CTNNA2,SORBS1
2.021e-03	-6.20	skin-face-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-face-malignant_melanoma-lentigo_maligna	23	2	16828	49	PREX2,FGFR3
2.045e-03	-6.19	actin cytoskeleton	cellular component	GO:0015629	520	6	19108	49	NEBL,ABLIM1,SORBS1,FMN2,MACF1,CTNNA2
2.130e-03	-6.15	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	50	SLC1A3,SLC1A2
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	CTNNA2,DTNA,CDH20
2.178e-03	-6.13	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	5	19454	50	TNIK,NEBL,MACF1,SORBS1,PARD3
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	ABLIM1,DTNA
2.185e-03	-6.13	extremity	COSMIC cancer mutations	extremity	1876	13	16828	49	CDH20,NEBL,NTRK2,PITPNC1,PREX2,FBXL7,PTPRZ1,ATP13A4,FGFR3,RYR3,PARD3,ADCY2,FMN2
2.189e-03	-6.12	Pancreatic secretion	KEGG pathways	ko04972	95	3	7161	20	ATP1A2,ADCY2,SLC4A4
2.189e-03	-6.12	Pancreatic secretion	KEGG pathways	hsa04972	95	3	7161	20	ATP1A2,ADCY2,SLC4A4
2.196e-03	-6.12	adenoma	COSMIC cancer mutations	adenoma	2873	17	16828	49	PTPRZ1,NPAS3,NTRK2,BMPR1B,SOX5,CDH20,HIF3A,NEBL,PARD3,ADCY2,GPC5,GPM6A,RYR3,ZBTB20,MACF1,FGFR3,CTNND2
2.200e-03	-6.12	EZR (ezrin)	protein interactions	7430	526	6	19454	50	NEBL,DTNA,TNIK,ABLIM1,MACF1,SORBS1
2.226e-03	-6.11	membrane	cellular component	GO:0016020	9220	34	19108	49	TNIK,NTRK2,NRG3,CTNND2,CTNNA2,PARD3,HIF3A,BMPR1B,ATP1A2,FGFR3,NKAIN3,SLC1A3,LSAMP,ZNRF3,SLC1A2,MACF1,SLC4A4,PREX2,DTNA,PARD3B,GPM6A,ADCY2,CST3,PTPRZ1,NTM,RYR3,SORBS1,FMN2,ATP13A4,SFXN5,CDH20,LRIG1,GPC5,NRXN1
2.261e-03	-6.09	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	7	16828	49	PREX2,SORBS1,NFIA,NEBL,FMN2,NTM,PTPRZ1
2.304e-03	-6.07	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	50	SLC1A3,SLC1A2
2.317e-03	-6.07	protein binding	molecular function	GO:0005515	13983	45	18094	48	GPM6A,HIF3A,BMPR1B,ABLIM1,NFIA,RORA,MSI2,CST3,ZNRF3,LRIG1,GPC5,SORBS1,PITPNC1,PARD3,PARD3B,CDH20,NRXN1,TRPS1,NRG3,CTNND2,TNIK,FMN2,GLIS3,CTNNA2,SLC1A2,SFXN5,NTRK2,PTPRZ1,RANBP3L,SPARCL1,LSAMP,FBXL7,ADCY2,SLC4A4,FGFR3,NTM,SOX5,NEBL,RFX4,RYR3,SLC1A3,MACF1,DTNA,ATP1A2,NPAS3
2.319e-03	-6.07	CTNNB1 (catenin beta 1)	protein interactions	1499	926	8	19454	50	DTNA,PTPRZ1,CTNND2,CTNNA2,PARD3B,SORBS1,PARD3,NHSL1
2.341e-03	-6.06	actin filament binding	molecular function	GO:0051015	211	4	18094	48	NEBL,ABLIM1,CTNNA2,MACF1
2.377e-03	-6.04	skeletal system development	biological process	GO:0001501	500	6	18204	50	BMPR1B,SOX5,FGFR3,RANBP3L,NFIA,TRPS1
2.412e-03	-6.03	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	5	16828	49	SORBS1,ADCY2,PTPRZ1,PARD3B,NTM
2.414e-03	-6.03	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	11	16828	49	RFX4,PTPRZ1,FMN2,RYR3,MACF1,CTNND2,PREX2,FGFR3,CDH20,NRXN1,NEBL
2.414e-03	-6.03	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	11	16828	49	RFX4,PTPRZ1,NRXN1,NEBL,CDH20,PREX2,RYR3,FMN2,CTNND2,FGFR3,MACF1
2.424e-03	-6.02	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	3	19454	50	ABLIM1,SPARCL1,SORBS1
2.440e-03	-6.02	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	11	16828	49	NRXN1,CTNND2,TNIK,SORBS1,RYR3,TRPS1,SLC4A4,FMN2,GPC5,PARD3,LSAMP
2.511e-03	-5.99	IGc2	smart domains	SM00408	239	5	9717	39	NTRK2,LSAMP,FGFR3,LRIG1,NTM
2.514e-03	-5.99	INSC (INSC spindle orientation adaptor protein)	protein interactions	387755	29	2	19454	50	PARD3B,PARD3
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	50	NRXN1
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Sh2b1 (SH2B adaptor protein 1)	protein interactions	20399	1	1	19454	50	FGFR3
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	fgf3.L (fibroblast growth factor 3 L homeolog)	protein interactions	373669	1	1	19454	50	FGFR3
2.593e-03	-5.95	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	44	ATP1A2,ATP13A4
2.614e-03	-5.95	response to alkaloid	biological process	GO:0043279	100	3	18204	50	SLC1A3,RYR3,SLC1A2
2.626e-03	-5.94	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	16	16828	49	RYR3,PARD3B,FMN2,GLIS3,ADCY2,RORA,NFIA,ZNRF3,FGFR3,CTNND2,MACF1,SORBS1,SPARCL1,NPAS3,PTPRZ1,PREX2
2.626e-03	-5.94	embryonal	COSMIC cancer mutations	embryonal	2659	16	16828	49	PREX2,SPARCL1,NPAS3,PTPRZ1,NFIA,ZNRF3,CTNND2,FGFR3,SORBS1,MACF1,RYR3,GLIS3,FMN2,PARD3B,RORA,ADCY2
2.653e-03	-5.93	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	48	NTRK2
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A2,SLC1A3
2.681e-03	-5.92	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	5	16828	49	SORBS1,PTPRZ1,ADCY2,NTM,PARD3B
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	ZNRF3_Znf_RING	interpro domains	IPR045903	1	1	18521	50	ZNRF3
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	NPAS3,PITPNC1,NTRK2,ATP1A2,CDH20,NTM,ADCY2,SORBS1,DTNA,RFX4,SPARCL1,PARD3B,ZBTB20,SLC1A3,CTNND2,MACF1,SFXN5,LSAMP,NHSL1,SOX5,BMPR1B,LRIG1,HIF3A,NRXN1,GPC5,FMN2,GLIS3,RORA,PARD3,RYR3,TNIK,FGFR3,NKAIN3,NFIA,ABLIM1,CST3,RANBP3L,FBXL7,PTPRZ1,TRPS1,NRG3,SLC4A4,PREX2,NEBL,GPM6A,ATP13A4,SLC1A2,ZNRF3
2.722e-03	-5.91	t(4;14) translocations of FGFR3	REACTOME pathways	R-HSA-2033515	1	1	10285	28	FGFR3
2.747e-03	-5.90	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	50	CST3
2.747e-03	-5.90	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	50	FMN2
2.747e-03	-5.90	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	50	NRG3
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	50	NTRK2
2.747e-03	-5.90	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	50	NRG3
2.747e-03	-5.90	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	50	CST3
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	50	NTRK2
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.754e-03	-5.89	FGFR3_TM	pfam domains	PF21165	1	1	17795	49	FGFR3
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	GPM6A,ZNRF3,SLC1A2,ATP13A4,SLC4A4,NRG3,TRPS1,FBXL7,PTPRZ1,RANBP3L,NEBL,PREX2,RYR3,RORA,PARD3,GLIS3,GPC5,FMN2,CST3,NFIA,ABLIM1,NKAIN3,TNIK,FGFR3,NHSL1,LSAMP,NRXN1,HIF3A,LRIG1,BMPR1B,SOX5,SLC1A3,ZBTB20,PARD3B,SFXN5,MACF1,CTNND2,SPARCL1,RFX4,ADCY2,NTM,DTNA,SORBS1,NPAS3,CDH20,ATP1A2,NTRK2,PITPNC1
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CTNNA2,CDH20
2.862e-03	-5.86	ACTB (actin beta)	protein interactions	60	958	8	19454	50	NEBL,SFXN5,ABLIM1,MACF1,NHSL1,SORBS1,DTNA,FMN2
2.863e-03	-5.86	myelination in peripheral nervous system	biological process	GO:0022011	29	2	18204	50	PARD3,NTRK2
2.863e-03	-5.86	peripheral nervous system axon ensheathment	biological process	GO:0032292	29	2	18204	50	NTRK2,PARD3
2.863e-03	-5.86	DST (dystonin)	protein interactions	667	230	4	19454	50	NTRK2,TNIK,PARD3,ATP1A2
2.870e-03	-5.85	SH2B1 (SH2B adaptor protein 1)	protein interactions	25970	31	2	19454	50	FGFR3,NTRK2
2.964e-03	-5.82	animal organ development	biological process	GO:0048513	2846	16	18204	50	RORA,SOX5,BMPR1B,SLC1A2,ATP1A2,ABLIM1,RANBP3L,GPM6A,RFX4,NFIA,NEBL,CTNNA2,NRG3,FGFR3,LRIG1,NTRK2
2.968e-03	-5.82	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	3	10285	28	SLC4A4,SLC1A2,SLC1A3
2.991e-03	-5.81	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	3	19454	50	NFIA,SOX5,TRPS1
2.993e-03	-5.81	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	8	19454	50	PITPNC1,FGFR3,NHSL1,SORBS1,PARD3,MACF1,ABLIM1,PARD3B
3.002e-03	-5.81	neural precursor cell proliferation	biological process	GO:0061351	105	3	18204	50	NFIA,RORA,SOX5
3.041e-03	-5.80	-	gene3d domains	6.10.250.1740	1	1	14470	44	FGFR3
3.044e-03	-5.79	glial cell differentiation	biological process	GO:0010001	219	4	18204	50	PTPRZ1,PARD3,NFIA,NTRK2
3.062e-03	-5.79	L-glutamate import	biological process	GO:0051938	30	2	18204	50	SLC1A3,SLC1A2
3.093e-03	-5.78	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	4	19454	50	DTNA,NTRK2,PARD3,MACF1
3.132e-03	-5.77	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	14	16828	49	DTNA,NFIA,TNIK,FGFR3,ADCY2,PARD3B,ATP1A2,BMPR1B,NTRK2,PREX2,SOX5,SLC4A4,TRPS1,PTPRZ1
3.222e-03	-5.74	SMAD7 (SMAD family member 7)	protein interactions	4092	115	3	19454	50	BMPR1B,PARD3,SOX5
3.225e-03	-5.74	axonogenesis	biological process	GO:0007409	366	5	18204	50	BMPR1B,PTPRZ1,CTNNA2,NRXN1,PARD3
3.282e-03	-5.72	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	49	ATP1A2,ATP13A4
3.353e-03	-5.70	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	12	19454	50	MACF1,PARD3B,TRPS1,NFIA,FGFR3,MSI2,ZBTB20,BMPR1B,PARD3,ABLIM1,NRG3,DTNA
3.430e-03	-5.68	skin-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-malignant_melanoma-acral_lentiginous	30	2	16828	49	PREX2,FGFR3
3.430e-03	-5.68	lentigo_maligna	COSMIC cancer mutations	lentigo_maligna	30	2	16828	49	FGFR3,PREX2
3.445e-03	-5.67	brain development	biological process	GO:0007420	724	7	18204	50	RORA,NRG3,CTNNA2,RFX4,SLC1A2,ATP1A2,NTRK2
3.479e-03	-5.66	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	50	BMPR1B,SOX5
3.479e-03	-5.66	microtubule organizing center localization	biological process	GO:0061842	32	2	18204	50	PARD3,PARD3B
3.479e-03	-5.66	positive regulation of ATP metabolic process	biological process	GO:1903580	32	2	18204	50	SLC4A4,ZBTB20
3.479e-03	-5.66	centrosome localization	biological process	GO:0051642	32	2	18204	50	PARD3B,PARD3
3.479e-03	-5.66	transepithelial transport	biological process	GO:0070633	32	2	18204	50	SLC1A2,SLC1A3
3.482e-03	-5.66	cell adhesion molecule binding	molecular function	GO:0050839	560	6	18094	48	PTPRZ1,CTNND2,CTNNA2,MACF1,CDH20,NRXN1
3.495e-03	-5.66	Cation_ATPase	pfam domains	PF13246	32	2	17795	49	ATP1A2,ATP13A4
3.497e-03	-5.66	signaling	biological process	GO:0023052	4968	23	18204	50	SLC1A3,SPARCL1,FGFR3,NTRK2,ADCY2,RYR3,ATP1A2,PREX2,SORBS1,FMN2,CTNND2,TNIK,NFIA,DTNA,PARD3,NRXN1,NRG3,BMPR1B,RORA,ZNRF3,SLC1A2,PITPNC1,MACF1
3.531e-03	-5.65	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	3	16828	49	PARD3,GPC5,NRG3
3.621e-03	-5.62	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	41	16828	49	MACF1,CTNND2,ATP13A4,SLC1A2,SFXN5,ZNRF3,PARD3B,SLC1A3,ZBTB20,PREX2,NEBL,PTPRZ1,FBXL7,RANBP3L,SLC4A4,NRG3,TRPS1,SORBS1,TNIK,FGFR3,DTNA,CST3,PARD3,RORA,ADCY2,GLIS3,FMN2,GPC5,NTM,RYR3,ATP1A2,BMPR1B,NTRK2,SOX5,CDH20,MSI2,LRIG1,NRXN1,LSAMP,NHSL1,NPAS3
3.635e-03	-5.62	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	19	NTRK2
3.677e-03	-5.61	Glutamatergic synapse	KEGG pathways	hsa04724	114	3	7161	20	SLC1A2,ADCY2,SLC1A3
3.677e-03	-5.61	Glutamatergic synapse	KEGG pathways	ko04724	114	3	7161	20	SLC1A2,ADCY2,SLC1A3
3.688e-03	-5.60	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	3	18094	48	SLC1A3,SLC4A4,SLC1A2
3.692e-03	-5.60	dendrite development	biological process	GO:0016358	113	3	18204	50	CTNNA2,CTNND2,PREX2
3.724e-03	-5.59	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	3	16828	49	NEBL,HIF3A,PARD3B
3.741e-03	-5.59	connective tissue development	biological process	GO:0061448	232	4	18204	50	FGFR3,NFIA,BMPR1B,SOX5
3.792e-03	-5.57	PAS-like_dom_sf	interpro domains	IPR035965	34	2	18521	50	HIF3A,NPAS3
3.792e-03	-5.57	PAS	interpro domains	IPR000014	34	2	18521	50	NPAS3,HIF3A
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A3,SLC1A2
3.925e-03	-5.54	cell communication	biological process	GO:0007154	5010	23	18204	50	RYR3,ZNRF3,RORA,BMPR1B,SLC1A2,PREX2,ATP1A2,MACF1,PITPNC1,SORBS1,TNIK,SLC1A3,FMN2,CTNND2,PARD3,NRXN1,NFIA,DTNA,SPARCL1,NRG3,ADCY2,NTRK2,FGFR3
3.936e-03	-5.54	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	21	16828	49	CDH20,PREX2,NPAS3,NHSL1,SPARCL1,TRPS1,PTPRZ1,ZNRF3,NFIA,MACF1,SORBS1,FGFR3,CTNND2,SLC1A3,RYR3,PARD3,RORA,ADCY2,PARD3B,FMN2,GLIS3
3.969e-03	-5.53	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	4	19454	50	TNIK,NTRK2,NHSL1,SORBS1
3.979e-03	-5.53	glutamatergic synapse	cellular component	GO:0098978	412	5	19108	49	SPARCL1,NRG3,SLC1A2,GPM6A,TNIK
4.014e-03	-5.52	DELLA	smart domains	SM01129	1	1	9717	39	MACF1
4.032e-03	-5.51	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	48	16828	49	NHSL1,LSAMP,HIF3A,LRIG1,NRXN1,MSI2,SOX5,BMPR1B,RYR3,FMN2,GPC5,GLIS3,PARD3,RORA,ABLIM1,NFIA,TNIK,FGFR3,NKAIN3,TRPS1,SLC4A4,NRG3,RANBP3L,PTPRZ1,FBXL7,NEBL,PREX2,GPM6A,ZNRF3,ATP13A4,SLC1A2,NPAS3,CDH20,PITPNC1,NTRK2,ATP1A2,NTM,ADCY2,DTNA,SORBS1,SPARCL1,RFX4,ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1
4.071e-03	-5.50	HPCA (hippocalcin)	protein interactions	3208	37	2	19454	50	GPM6A,CST3
4.094e-03	-5.50	transporter activity	molecular function	GO:0005215	1211	9	18094	48	SLC4A4,ATP1A2,PITPNC1,SFXN5,SLC1A2,ATP13A4,SLC1A3,RYR3,GPM6A
4.102e-03	-5.50	Ig_sub	interpro domains	IPR003599	394	5	18521	50	FGFR3,NTM,LRIG1,NTRK2,LSAMP
4.169e-03	-5.48	synapse assembly	biological process	GO:0007416	118	3	18204	50	NRXN1,GPM6A,NRG3
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP13A4,ATP1A2
4.257e-03	-5.46	response to endogenous stimulus	biological process	GO:0009719	1402	10	18204	50	NFIA,SLC1A2,ATP1A2,SOX5,RYR3,BMPR1B,SLC1A3,SORBS1,FGFR3,NTRK2
4.289e-03	-5.45	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	49	PREX2,FGFR3,ATP13A4,CTNND2,MACF1,SORBS1,SLC4A4,NTM,ADCY2
4.370e-03	-5.43	striated muscle contraction	biological process	GO:0006941	120	3	18204	50	DTNA,ATP1A2,RYR3
4.413e-03	-5.42	arm	COSMIC cancer mutations	arm	1331	10	16828	49	NTM,PARD3B,TRPS1,ZBTB20,NPAS3,SLC4A4,FGFR3,ATP1A2,SORBS1,MACF1
4.442e-03	-5.42	PAS	smart domains	SM00091	25	2	9717	39	NPAS3,HIF3A
4.451e-03	-5.41	monoatomic ion transport	biological process	GO:0006811	964	8	18204	50	ATP1A2,SFXN5,SLC1A2,SLC1A3,SLC4A4,RYR3,GPM6A,ATP13A4
4.455e-03	-5.41	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	6	18094	48	ATP1A2,SLC1A2,GPM6A,SLC1A3,SLC4A4,RYR3
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP13A4,ATP1A2
4.494e-03	-5.41	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	4	19454	50	DTNA,FMN2,PARD3,MACF1
4.602e-03	-5.38	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	6	19454	50	ABLIM1,TNIK,PARD3,NHSL1,FGFR3,DTNA
4.603e-03	-5.38	organic anion transport	biological process	GO:0015711	398	5	18204	50	SLC1A2,SFXN5,NTRK2,SLC4A4,SLC1A3
4.604e-03	-5.38	PDZ	pfam domains	PF00595	122	3	17795	49	PARD3,PARD3B,PREX2
4.605e-03	-5.38	regulation of synapse organization	biological process	GO:0050807	246	4	18204	50	NRXN1,NTRK2,GPM6A,CTNNA2
4.616e-03	-5.38	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	28	16828	49	NTRK2,ATP1A2,BMPR1B,SOX5,PITPNC1,NRXN1,LRIG1,RORA,PARD3,ADCY2,GPC5,FMN2,NTM,RYR3,TNIK,FGFR3,ABLIM1,NFIA,PTPRZ1,RFX4,NRG3,SLC4A4,PREX2,ZBTB20,MACF1,ATP13A4,CTNND2,ZNRF3
4.616e-03	-5.38	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	28	16828	49	NTRK2,BMPR1B,ATP1A2,SOX5,PITPNC1,NRXN1,LRIG1,FGFR3,TNIK,NFIA,ABLIM1,RORA,PARD3,ADCY2,NTM,FMN2,GPC5,RYR3,PREX2,PTPRZ1,RFX4,SLC4A4,NRG3,MACF1,ATP13A4,CTNND2,ZNRF3,ZBTB20
4.631e-03	-5.38	positive regulation of nucleotide metabolic process	biological process	GO:0045981	37	2	18204	50	ZBTB20,SLC4A4
4.631e-03	-5.38	positive regulation of purine nucleotide metabolic process	biological process	GO:1900544	37	2	18204	50	SLC4A4,ZBTB20
4.631e-03	-5.38	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	50	SORBS1,SLC1A2
4.632e-03	-5.37	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	44	16828	49	NPAS3,PITPNC1,NTRK2,ATP1A2,CDH20,NTM,ADCY2,SORBS1,RFX4,SPARCL1,PARD3B,ZBTB20,SLC1A3,CTNND2,MACF1,SFXN5,LSAMP,NHSL1,SOX5,BMPR1B,HIF3A,NRXN1,LRIG1,GPC5,FMN2,GLIS3,RORA,PARD3,RYR3,FGFR3,TNIK,NKAIN3,NFIA,ABLIM1,RANBP3L,PTPRZ1,FBXL7,TRPS1,NRG3,PREX2,NEBL,GPM6A,SLC1A2,ATP13A4
4.744e-03	-5.35	DZIP1 (DAZ interacting zinc finger protein 1)	protein interactions	22873	40	2	19454	50	NTRK2,PARD3
4.868e-03	-5.33	dendrite	cellular component	GO:0030425	620	6	19108	49	GPM6A,ADCY2,BMPR1B,NTRK2,ATP1A2,CTNND2
4.880e-03	-5.32	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	50	SLC1A2,SLC1A3
4.944e-03	-5.31	dendritic tree	cellular component	GO:0097447	622	6	19108	49	ATP1A2,CTNND2,ADCY2,BMPR1B,NTRK2,GPM6A
4.963e-03	-5.31	head development	biological process	GO:0060322	774	7	18204	50	RORA,CTNNA2,NRG3,RFX4,SLC1A2,ATP1A2,NTRK2
4.969e-03	-5.30	intracellular chemical homeostasis	biological process	GO:0055082	581	6	18204	50	RYR3,SLC4A4,ATP13A4,SLC1A3,ZBTB20,ATP1A2
4.977e-03	-5.30	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	21	16828	49	PTPRZ1,TRPS1,SPARCL1,NPAS3,NHSL1,PREX2,CDH20,GLIS3,FMN2,PARD3B,ADCY2,RORA,PARD3,RYR3,SLC1A3,CTNND2,FGFR3,SORBS1,MACF1,NFIA,ZNRF3
5.014e-03	-5.30	regulation of synapse structure or activity	biological process	GO:0050803	252	4	18204	50	NRXN1,NTRK2,GPM6A,CTNNA2
5.042e-03	-5.29	testis	COSMIC cancer mutations	testis	733	7	16828	49	TRPS1,BMPR1B,NTRK2,MACF1,FGFR3,PREX2,TNIK
5.109e-03	-5.28	forebrain development	biological process	GO:0030900	408	5	18204	50	RFX4,SLC1A2,ATP1A2,NTRK2,NRG3
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	DTNA,SPARCL1,MACF1,RYR3
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	50	ATP1A2,SLC1A3
5.157e-03	-5.27	animal organ morphogenesis	biological process	GO:0009887	988	8	18204	50	BMPR1B,SOX5,NTRK2,LRIG1,FGFR3,NRG3,CTNNA2,ABLIM1
5.198e-03	-5.26	RDX (radixin)	protein interactions	5962	272	4	19454	50	ABLIM1,NEBL,FGFR3,MACF1
5.251e-03	-5.25	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	3	16828	49	DTNA,CDH20,FGFR3
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	44	ATP13A4,ATP1A2
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	44	ATP13A4,ATP1A2
5.366e-03	-5.23	NFIB (nuclear factor I B)	protein interactions	4781	138	3	19454	50	TRPS1,SOX5,NFIA
5.373e-03	-5.23	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	11	18204	50	ATP1A2,NRXN1,SFXN5,PARD3,BMPR1B,SOX5,RORA,NTRK2,MACF1,ZBTB20,PTPRZ1
5.392e-03	-5.22	ZNRF-3_ecto	interpro domains	IPR040700	2	1	18521	50	ZNRF3
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.395e-03	-5.22	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	2	18204	50	ADCY2,RORA
5.422e-03	-5.22	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	13	16828	49	PTPRZ1,TRPS1,SLC4A4,PREX2,SOX5,ATP1A2,BMPR1B,NTRK2,ADCY2,FGFR3,TNIK,NFIA,DTNA
5.431e-03	-5.22	PAS	prosite domains	PS50112	30	2	12186	45	HIF3A,NPAS3
5.486e-03	-5.21	Wnt receptor catabolic process	biological process	GO:0038018	2	1	18204	50	ZNRF3
5.486e-03	-5.21	mesenchymal cell differentiation involved in bone development	biological process	GO:1901706	2	1	18204	50	RANBP3L
5.486e-03	-5.21	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	50	CST3
5.486e-03	-5.21	fibroblast growth factor receptor apoptotic signaling pathway	biological process	GO:1902178	2	1	18204	50	FGFR3
5.486e-03	-5.21	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	50	CST3
5.492e-03	-5.20	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	4	18094	48	SFXN5,SLC1A2,SLC4A4,SLC1A3
5.493e-03	-5.20	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	3	17795	49	FGFR3,BMPR1B,NTRK2
5.500e-03	-5.20	ZNRF_3_ecto	pfam domains	PF18212	2	1	17795	49	ZNRF3
5.505e-03	-5.20	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	7	16828	49	NRG3,PARD3,CDH20,FGFR3,PREX2,ATP13A4,MACF1
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A3,SLC1A2
5.547e-03	-5.19	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	50	NTRK2,FGFR3,BMPR1B
5.662e-03	-5.17	cyclic nucleotide metabolic process	biological process	GO:0009187	41	2	18204	50	RORA,ADCY2
5.766e-03	-5.16	axon development	biological process	GO:0061564	420	5	18204	50	CTNNA2,PTPRZ1,BMPR1B,PARD3,NRXN1
5.767e-03	-5.16	sarcolemma	cellular component	GO:0042383	142	3	19108	49	DTNA,ATP1A2,RYR3
5.784e-03	-5.15	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	18	16828	49	MACF1,FGFR3,ATP13A4,CTNND2,PARD3,ADCY2,FMN2,GPC5,GLIS3,LRIG1,NEBL,NRXN1,ATP1A2,PREX2,PITPNC1,NRG3,PTPRZ1,RFX4
5.885e-03	-5.14	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	4	16828	49	PTPRZ1,MACF1,FGFR3,GLIS3
5.922e-03	-5.13	SLC6A15 (solute carrier family 6 member 15)	protein interactions	55117	143	3	19454	50	SFXN5,NTRK2,PARD3
5.935e-03	-5.13	Schwann cell development	biological process	GO:0014044	42	2	18204	50	PARD3,NTRK2
5.968e-03	-5.12	small_intestine	COSMIC cancer mutations	small_intestine	250	4	16828	49	TNIK,FGFR3,MACF1,ZNRF3
6.001e-03	-5.12	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	8	19454	50	FMN2,PITPNC1,PARD3B,ABLIM1,MACF1,NHSL1,SORBS1,PARD3
6.035e-03	-5.11	Ig-like_dom	interpro domains	IPR007110	432	5	18521	50	NTM,NTRK2,LRIG1,LSAMP,FGFR3
6.037e-03	-5.11	Calml3 (calmodulin-like 3)	protein interactions	70405	144	3	19454	50	ABLIM1,ZBTB20,MACF1
6.073e-03	-5.10	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	44	CTNNA2
6.073e-03	-5.10	-	gene3d domains	6.20.350.10	2	1	14470	44	RYR3
6.107e-03	-5.10	axon	cellular component	GO:0030424	650	6	19108	49	NTRK2,SLC1A2,GPM6A,CTNNA2,DTNA,PARD3
6.108e-03	-5.10	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	5	19454	50	CTNND2,DTNA,FMN2,MACF1,PARD3
6.211e-03	-5.08	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	15	16828	49	NTRK2,ATP1A2,SOX5,LRIG1,PTPRZ1,RFX4,NRG3,NHSL1,FGFR3,CTNND2,SLC1A2,ZNRF3,ADCY2,FMN2,ZBTB20
6.237e-03	-5.08	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	5	18204	50	ATP1A2,RYR3,SLC4A4,SLC1A3,ATP13A4
6.257e-03	-5.07	active transmembrane transporter activity	molecular function	GO:0022804	444	5	18094	48	SLC1A3,ATP13A4,SLC4A4,ATP1A2,SLC1A2
6.338e-03	-5.06	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	17	CST3,SLC1A2
6.372e-03	-5.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	39	16828	49	NEBL,PREX2,SLC4A4,NRG3,SPARCL1,PTPRZ1,FBXL7,RFX4,RANBP3L,SFXN5,MACF1,CTNND2,SLC1A2,ATP13A4,SLC1A3,PARD3B,CDH20,HIF3A,NRXN1,LRIG1,MSI2,NTRK2,ATP1A2,SOX5,NPAS3,NHSL1,LSAMP,ABLIM1,NFIA,NKAIN3,TNIK,RYR3,RORA,ADCY2,PARD3,GPC5,FMN2,NTM,GLIS3
6.372e-03	-5.06	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	39	16828	49	SLC1A3,PARD3B,SFXN5,MACF1,CTNND2,ATP13A4,SLC1A2,NRG3,SLC4A4,SPARCL1,PTPRZ1,FBXL7,RFX4,RANBP3L,NEBL,PREX2,RYR3,ADCY2,PARD3,RORA,GPC5,NTM,FMN2,GLIS3,NFIA,ABLIM1,NKAIN3,TNIK,NPAS3,NHSL1,LSAMP,CDH20,LRIG1,HIF3A,NRXN1,MSI2,NTRK2,ATP1A2,SOX5
6.402e-03	-5.05	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	12	16828	49	FMN2,FBXL7,PTPRZ1,PARD3,ADCY2,RYR3,ATP13A4,PITPNC1,PREX2,NTRK2,NEBL,CDH20
6.420e-03	-5.05	trans-synaptic signaling	biological process	GO:0099537	431	5	18204	50	NTRK2,SLC1A2,NRXN1,DTNA,SLC1A3
6.435e-03	-5.05	cytoskeleton organization	biological process	GO:0007010	1251	9	18204	50	FMN2,TNIK,NEBL,PARD3,CTNNA2,ABLIM1,SORBS1,MACF1,PARD3B
6.441e-03	-5.05	membrane raft	cellular component	GO:0045121	290	4	19108	49	SORBS1,SLC1A2,ATP1A2,ADCY2
6.441e-03	-5.04	regulation of generation of precursor metabolites and energy	biological process	GO:0043467	138	3	18204	50	SORBS1,ZBTB20,SLC4A4
6.498e-03	-5.04	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	50	SLC1A2,SORBS1
6.500e-03	-5.04	CNTN1 (contactin 1)	protein interactions	1272	47	2	19454	50	PTPRZ1,GPM6A
6.550e-03	-5.03	PAS domain	gene3d domains	3.30.450.20	40	2	14470	44	HIF3A,NPAS3
6.597e-03	-5.02	membrane microdomain	cellular component	GO:0098857	292	4	19108	49	ADCY2,ATP1A2,SLC1A2,SORBS1
6.634e-03	-5.02	GSE1 (Gse1 coiled-coil protein)	protein interactions	23199	149	3	19454	50	TNIK,SOX5,NFIA
6.634e-03	-5.02	vascular process in circulatory system	biological process	GO:0003018	273	4	18204	50	SLC1A2,ATP1A2,SLC4A4,SLC1A3
6.646e-03	-5.01	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	15	16828	49	NRG3,TRPS1,PTPRZ1,LSAMP,CDH20,NRXN1,NEBL,ATP1A2,SOX5,PREX2,SLC1A3,RYR3,PARD3,ATP13A4,CTNND2
6.660e-03	-5.01	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	4	16828	49	FMN2,ATP13A4,PTPRZ1,SLC4A4
6.709e-03	-5.00	apical junction complex	cellular component	GO:0043296	150	3	19108	49	PARD3B,PARD3,SORBS1
6.770e-03	-5.00	ErbB4 signaling events	Pathway Interaction DB	erbb4_pathway	32	2	2226	9	LRIG1,NRG3
6.798e-03	-4.99	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	5	18204	50	RYR3,ATP13A4,SLC1A3,SLC4A4,ATP1A2
6.804e-03	-4.99	gliogenesis	biological process	GO:0042063	275	4	18204	50	NTRK2,NFIA,PARD3,PTPRZ1
6.870e-03	-4.98	uveal_tract	COSMIC cancer mutations	uveal_tract	587	6	16828	49	RANBP3L,ADCY2,FGFR3,PREX2,CTNND2,MACF1
6.890e-03	-4.98	learning or memory	biological process	GO:0007611	276	4	18204	50	PTPRZ1,NTRK2,ATP1A2,NRXN1
6.935e-03	-4.97	CATATPASE	prints domains	PR00119	35	2	5227	19	ATP13A4,ATP1A2
6.941e-03	-4.97	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	7	16828	49	FGFR3,TNIK,SOX5,CTNND2,NTRK2,BMPR1B,ADCY2
6.941e-03	-4.97	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	7	16828	49	ADCY2,SOX5,FGFR3,TNIK,CTNND2,NTRK2,BMPR1B
6.969e-03	-4.97	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	50	SLC4A4,SLC1A3,SLC1A2
6.969e-03	-4.97	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	50	SLC4A4,ZBTB20,SORBS1
7.084e-03	-4.95	regulation of myelination	biological process	GO:0031641	46	2	18204	50	PARD3,PTPRZ1
7.087e-03	-4.95	symporter activity	molecular function	GO:0015293	148	3	18094	48	SLC1A2,SLC1A3,SLC4A4
7.095e-03	-4.95	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	6	18204	50	NTRK2,SORBS1,FGFR3,NFIA,BMPR1B,NRG3
7.135e-03	-4.94	SOX6 (SRY-box transcription factor 6)	protein interactions	55553	153	3	19454	50	NFIA,TRPS1,SOX5
7.175e-03	-4.94	PDZ	interpro domains	IPR001478	146	3	18521	50	PARD3B,PREX2,PARD3
7.213e-03	-4.93	system process	biological process	GO:0003008	2015	12	18204	50	SLC4A4,SLC1A3,RYR3,ATP1A2,DTNA,NRXN1,SLC1A2,CTNNA2,PTPRZ1,ABLIM1,LRIG1,NTRK2
7.257e-03	-4.93	FORMIN	prints domains	PR00828	2	1	5227	19	FMN2
7.372e-03	-4.91	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	45	SPARCL1
7.372e-03	-4.91	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	45	SPARCL1
7.386e-03	-4.91	regulation of neuron migration	biological process	GO:2001222	47	2	18204	50	NRG3,CTNNA2
7.386e-03	-4.91	Schwann cell differentiation	biological process	GO:0014037	47	2	18204	50	PARD3,NTRK2
7.493e-03	-4.89	cell surface	cellular component	GO:0009986	896	7	19108	49	SLC4A4,FGFR3,ATP1A2,SLC1A3,SLC1A2,GPC5,NRXN1
7.515e-03	-4.89	Wnt signaling pathway	biological process	GO:0016055	283	4	18204	50	CTNND2,TNIK,ZNRF3,MACF1
7.525e-03	-4.89	CEP19 (centrosomal protein 19)	protein interactions	84984	156	3	19454	50	PARD3,ABLIM1,FMN2
7.587e-03	-4.88	PDZ_sf	interpro domains	IPR036034	149	3	18521	50	PARD3,PREX2,PARD3B
7.592e-03	-4.88	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	49	ZNRF3,MACF1
7.592e-03	-4.88	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	49	MACF1,ZNRF3
7.617e-03	-4.88	FAM171B (family with sequence similarity 171 member B)	protein interactions	165215	51	2	19454	50	PARD3,NTRK2
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	NHSL1,MACF1
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.646e-03	-4.87	monoatomic cation transmembrane transport	biological process	GO:0098655	636	6	18204	50	SLC4A4,SLC1A3,RYR3,ATP1A2,ATP13A4,GPM6A
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	50	NRXN1
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.757e-03	-4.86	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	45	ATP1A2,ATP13A4
7.800e-03	-4.85	abdomen	COSMIC cancer mutations	abdomen	603	6	16828	49	RANBP3L,FMN2,LRIG1,PREX2,FGFR3,CTNND2
7.909e-03	-4.84	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	50	SORBS1,NTRK2
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.952e-03	-4.83	neuromuscular process	biological process	GO:0050905	149	3	18204	50	SLC1A3,CTNNA2,NRXN1
7.984e-03	-4.83	eye	COSMIC cancer mutations	eye	606	6	16828	49	CTNND2,PREX2,FGFR3,MACF1,RANBP3L,ADCY2
8.029e-03	-4.82	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	20	16828	49	GPC5,FMN2,PARD3B,PARD3,RORA,FGFR3,SLC1A2,CTNND2,ATP13A4,MACF1,ABLIM1,RFX4,TRPS1,NRG3,SLC4A4,PREX2,ATP1A2,LRIG1,NEBL,CDH20
8.065e-03	-4.82	SOX5 (SRY-box transcription factor 5)	protein interactions	6660	160	3	19454	50	NFIA,TRPS1,SOX5
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	50	HIF3A
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.097e-03	-4.82	regulation of nervous system development	biological process	GO:0051960	456	5	18204	50	NTRK2,NRXN1,PARD3,MACF1,PTPRZ1
8.218e-03	-4.80	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	50	FMN2
8.218e-03	-4.80	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	50	CTNNA2
8.218e-03	-4.80	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	50	NRXN1
8.218e-03	-4.80	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	50	FMN2
8.218e-03	-4.80	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	50	FMN2
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.218e-03	-4.80	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	50	NEBL
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.218e-03	-4.80	mammary placode formation	biological process	GO:0060596	3	1	18204	50	NRG3
8.218e-03	-4.80	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	50	NTRK2
8.238e-03	-4.80	SR_plectin_7	pfam domains	PF21097	3	1	17795	49	MACF1
8.238e-03	-4.80	Myelin_PLP	pfam domains	PF01275	3	1	17795	49	GPM6A
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR3
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR3
8.238e-03	-4.80	Sorb	pfam domains	PF02208	3	1	17795	49	SORBS1
8.238e-03	-4.80	HIF-1	pfam domains	PF11413	3	1	17795	49	HIF3A
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK2
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR3
8.244e-03	-4.80	transmembrane transporter activity	molecular function	GO:0022857	1110	8	18094	48	RYR3,SLC1A3,ATP13A4,GPM6A,SLC4A4,SLC1A2,SFXN5,ATP1A2
8.301e-03	-4.79	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	16	16828	49	FMN2,NTM,ADCY2,PARD3,FGFR3,MACF1,SPARCL1,NRG3,NPAS3,SLC4A4,BMPR1B,ATP1A2,NTRK2,MSI2,NEBL,HIF3A
8.301e-03	-4.79	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	16	16828	49	ADCY2,PARD3,NTM,FMN2,MACF1,FGFR3,NRG3,SLC4A4,NPAS3,SPARCL1,NTRK2,BMPR1B,ATP1A2,NEBL,HIF3A,MSI2
8.317e-03	-4.79	synaptic signaling	biological process	GO:0099536	459	5	18204	50	SLC1A3,DTNA,NRXN1,SLC1A2,NTRK2
8.392e-03	-4.78	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	28	SLC1A2,SLC1A3
8.458e-03	-4.77	DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	GO:0000981	1355	9	18094	48	RFX4,HIF3A,GLIS3,TRPS1,RORA,ZBTB20,SOX5,NPAS3,NFIA
8.500e-03	-4.77	Hippo signaling pathway	KEGG pathways	ko04390	154	3	7161	20	CTNNA2,BMPR1B,PARD3
8.500e-03	-4.77	Hippo signaling pathway	KEGG pathways	hsa04390	154	3	7161	20	CTNNA2,PARD3,BMPR1B
8.508e-03	-4.77	cellular component organization	biological process	GO:0016043	5636	24	18204	50	ABLIM1,GPM6A,PARD3B,MACF1,PITPNC1,BMPR1B,SLC1A2,PTPRZ1,NRG3,CDH20,CTNND2,FMN2,TNIK,CST3,NEBL,PARD3,NRXN1,NFIA,RFX4,SORBS1,RYR3,PREX2,CTNNA2,SPARCL1
8.603e-03	-4.76	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	48	2	16828	49	RYR3,PARD3
8.651e-03	-4.75	neuromuscular process controlling balance	biological process	GO:0050885	51	2	18204	50	SLC1A3,NRXN1
8.702e-03	-4.74	learning	biological process	GO:0007612	154	3	18204	50	ATP1A2,NTRK2,NRXN1
8.711e-03	-4.74	skin-hand-lentigo	COSMIC cancer mutations	skin-hand-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-lentigo	COSMIC cancer mutations	skin-leg-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-forearm-lentigo	COSMIC cancer mutations	skin-forearm-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-lentigo	COSMIC cancer mutations	skin-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-lentigo	COSMIC cancer mutations	skin-trunk-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	urinary_tract-bladder-papilloma	COSMIC cancer mutations	urinary_tract-bladder-papilloma	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-leg-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-trunk-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	lentigo	COSMIC cancer mutations	lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-face-lentigo	COSMIC cancer mutations	skin-face-lentigo	3	1	16828	49	FGFR3
8.712e-03	-4.74	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	48	ATP1A2,ATP13A4
8.748e-03	-4.74	ZYX (zyxin)	protein interactions	7791	316	4	19454	50	SORBS1,MACF1,ABLIM1,NEBL
8.771e-03	-4.74	EGR2 (early growth response 2)	protein interactions	1959	165	3	19454	50	SOX5,TRPS1,NFIA
8.771e-03	-4.74	positive regulation of nervous system development	biological process	GO:0051962	296	4	18204	50	PTPRZ1,NTRK2,MACF1,NRXN1
8.873e-03	-4.72	carboxylic acid transport	biological process	GO:0046942	297	4	18204	50	SLC1A3,SFXN5,SLC1A2,NTRK2
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	ABLIM1,NEBL,ATP1A2
8.976e-03	-4.71	organic acid transport	biological process	GO:0015849	298	4	18204	50	SLC1A3,NTRK2,SLC1A2,SFXN5
8.982e-03	-4.71	regulation of purine nucleotide catabolic process	biological process	GO:0033121	52	2	18204	50	ZBTB20,SLC4A4
8.982e-03	-4.71	regulation of glycolytic process	biological process	GO:0006110	52	2	18204	50	SLC4A4,ZBTB20
8.982e-03	-4.71	regulation of nucleotide catabolic process	biological process	GO:0030811	52	2	18204	50	SLC4A4,ZBTB20
9.095e-03	-4.70	-	gene3d domains	1.10.490.160	3	1	14470	44	RYR3
9.095e-03	-4.70	-	gene3d domains	6.10.250.2510	3	1	14470	44	CTNNA2
9.147e-03	-4.69	presynaptic membrane	cellular component	GO:0042734	168	3	19108	49	NRXN1,SLC1A2,GPM6A
9.171e-03	-4.69	positive regulation of synaptic transmission	biological process	GO:0050806	157	3	18204	50	NRXN1,NTRK2,SLC1A3
9.191e-03	-4.69	EF-hand	gene3d domains	1.10.238.10	272	4	14470	44	DTNA,MACF1,SPARCL1,RYR3
9.318e-03	-4.68	neutral amino acid transport	biological process	GO:0015804	53	2	18204	50	SLC1A3,SLC1A2
9.346e-03	-4.67	LRRNT	interpro domains	IPR000372	54	2	18521	50	LRIG1,NTRK2
9.442e-03	-4.66	NXPH3 (neurexophilin 3)	protein interactions	11248	57	2	19454	50	NRXN1,CTNNA2
9.492e-03	-4.66	monoatomic anion transport	biological process	GO:0006820	159	3	18204	50	SLC1A3,SLC4A4,SLC1A2
9.541e-03	-4.65	Ig-like_dom_sf	interpro domains	IPR036179	483	5	18521	50	LSAMP,NTRK2,LRIG1,NTM,FGFR3
9.616e-03	-4.64	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	48	16828	49	TNIK,FGFR3,NKAIN3,ABLIM1,NFIA,GLIS3,GPC5,FMN2,PARD3,RORA,RYR3,SOX5,BMPR1B,MSI2,NRXN1,LRIG1,HIF3A,LSAMP,NHSL1,SLC1A2,ATP13A4,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,FBXL7,PTPRZ1,TRPS1,SLC4A4,NRG3,SORBS1,DTNA,NTM,ADCY2,PITPNC1,ATP1A2,NTRK2,CDH20,NPAS3,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SPARCL1
9.634e-03	-4.64	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	49	16828	49	SORBS1,DTNA,NTM,ADCY2,PITPNC1,NTRK2,ATP1A2,CDH20,NPAS3,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SPARCL1,TNIK,FGFR3,NKAIN3,NFIA,ABLIM1,CST3,FMN2,GPC5,GLIS3,RORA,PARD3,RYR3,SOX5,BMPR1B,HIF3A,NRXN1,LRIG1,MSI2,LSAMP,NHSL1,ATP13A4,SLC1A2,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,PTPRZ1,FBXL7,TRPS1,SLC4A4,NRG3
9.704e-03	-4.64	RNA polymerase II transcription regulatory region sequence-specific DNA binding	molecular function	GO:0000977	1385	9	18094	48	GLIS3,HIF3A,RFX4,TRPS1,SOX5,NPAS3,NFIA,RORA,ZBTB20
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	ATP1A2,GPM6A,NTRK2
9.833e-03	-4.62	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	4	19454	50	TNIK,DTNA,PARD3,SORBS1
9.847e-03	-4.62	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	26	16828	49	GLIS3,RORA,ADCY2,PARD3,RYR3,FGFR3,NKAIN3,ABLIM1,DTNA,CST3,NPAS3,SOX5,NTRK2,ATP1A2,LRIG1,ZBTB20,SLC1A3,ATP13A4,CTNND2,MACF1,PTPRZ1,SPARCL1,NRG3,SLC4A4,PREX2,NEBL
9.950e-03	-4.61	CAV1 (caveolin 1)	protein interactions	857	719	6	19454	50	FMN2,DTNA,TNIK,PARD3,SLC1A3,MACF1
9.962e-03	-4.61	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	4	16828	49	NRG3,FGFR3,PARD3B,SLC1A2
9.962e-03	-4.61	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	4	16828	49	NRG3,PARD3B,FGFR3,SLC1A2
1.001e-02	-4.60	response to cocaine	biological process	GO:0042220	55	2	18204	50	SLC1A3,SLC1A2
1.001e-02	-4.60	establishment or maintenance of epithelial cell apical/basal polarity	biological process	GO:0045197	55	2	18204	50	PARD3,PARD3B
1.002e-02	-4.60	Znf_NHR/GATA	interpro domains	IPR013088	56	2	18521	50	RORA,TRPS1
1.005e-02	-4.60	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	2	10285	28	RYR3,ATP1A2
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	GPM6A,NTRK2,ATP1A2
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	CTNNA2,DTNA,CDH20
1.022e-02	-4.58	internode region of axon	cellular component	GO:0033269	4	1	19108	49	PARD3
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.029e-02	-4.58	LHX3 (LIM homeobox 3)	protein interactions	8022	175	3	19454	50	SOX5,TRPS1,NFIA
1.034e-02	-4.57	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	7	19454	50	CTNND2,ZBTB20,ATP13A4,ADCY2,NFIA,TRPS1,SLC1A3
1.041e-02	-4.56	-	gene3d domains	2.30.42.10	149	3	14470	44	PREX2,PARD3B,PARD3
1.042e-02	-4.56	SNTB1 (syntrophin beta 1)	protein interactions	6641	60	2	19454	50	FGFR3,DTNA
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	ATP1A2,SLC1A2,SLC1A3
1.057e-02	-4.55	citrate transmembrane transporter activity	molecular function	GO:0015137	4	1	18094	48	SFXN5
1.057e-02	-4.55	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	48	NTRK2
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.057e-02	-4.55	tricarboxylic acid transmembrane transporter activity	molecular function	GO:0015142	4	1	18094	48	SFXN5
1.061e-02	-4.55	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	13	16828	49	NRG3,NHSL1,RFX4,PTPRZ1,LRIG1,SOX5,ATP1A2,NTRK2,ZBTB20,FMN2,ZNRF3,CTNND2,SLC1A2
1.072e-02	-4.54	visual behavior	biological process	GO:0007632	57	2	18204	50	SLC1A2,ATP1A2
1.075e-02	-4.53	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	28	ATP1A2,ATP13A4
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	FGF_rcpt_fam	interpro domains	IPR016248	4	1	18521	50	FGFR3
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.077e-02	-4.53	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	3	19454	50	LRIG1,NTRK2,NRG3
1.087e-02	-4.52	RYANODINER	prints domains	PR00795	3	1	5227	19	RYR3
1.087e-02	-4.52	RORNUCRECPTR	prints domains	PR01293	3	1	5227	19	RORA
1.087e-02	-4.52	MYELINPLP	prints domains	PR00214	3	1	5227	19	GPM6A
1.087e-02	-4.52	NTKRECEPTOR	prints domains	PR01939	3	1	5227	19	NTRK2
1.090e-02	-4.52	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	6	16828	49	TNIK,FGFR3,PREX2,NTRK2,BMPR1B,TRPS1
1.093e-02	-4.52	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	298	4	16828	49	LRIG1,ATP1A2,CTNND2,FMN2
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	50	NTRK2
1.094e-02	-4.52	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	50	BMPR1B
1.094e-02	-4.52	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	50	NTRK2
1.094e-02	-4.52	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	50	CST3
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.097e-02	-4.51	Nebulin	pfam domains	PF00880	4	1	17795	49	NEBL
1.097e-02	-4.51	NHS	pfam domains	PF15273	4	1	17795	49	NHSL1
1.097e-02	-4.51	AbLIM_anchor	pfam domains	PF16182	4	1	17795	49	ABLIM1
1.097e-02	-4.51	Spectrin_4	pfam domains	PF21020	4	1	17795	49	MACF1
1.097e-02	-4.51	P5-ATPase	pfam domains	PF12409	4	1	17795	49	ATP13A4
1.097e-02	-4.51	Spectrin_2	pfam domains	PF18373	4	1	17795	49	MACF1
1.097e-02	-4.51	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	49	NFIA
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	CTF_NFI	pfam domains	PF00859	4	1	17795	49	NFIA
1.097e-02	-4.51	Spectrin_3	pfam domains	PF21019	4	1	17795	49	MACF1
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	RYR3,GLIS3,FMN2,GPC5,RORA,PARD3,ABLIM1,NFIA,CST3,TNIK,FGFR3,NKAIN3,NHSL1,LSAMP,MSI2,HIF3A,NRXN1,LRIG1,SOX5,BMPR1B,GPM6A,ZNRF3,SLC1A2,ATP13A4,TRPS1,NRG3,SLC4A4,RANBP3L,PTPRZ1,FBXL7,NEBL,PREX2,NTM,ADCY2,DTNA,SORBS1,NPAS3,CDH20,PITPNC1,ATP1A2,NTRK2,ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1,SPARCL1,RFX4
1.104e-02	-4.51	VINCULIN_1	prosite domains	PS00663	3	1	12186	45	CTNNA2
1.104e-02	-4.51	SOHO	prosite domains	PS50831	3	1	12186	45	SORBS1
1.104e-02	-4.51	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	45	GPM6A
1.104e-02	-4.51	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	45	GPM6A
1.107e-02	-4.50	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	6	18094	48	RYR3,SLC4A4,SLC1A3,SLC1A2,GPM6A,ATP1A2
1.110e-02	-4.50	cellular homeostasis	biological process	GO:0019725	689	6	18204	50	RYR3,SLC1A3,ATP13A4,SLC4A4,ZBTB20,ATP1A2
1.110e-02	-4.50	MYOD1 (myogenic differentiation 1)	protein interactions	4654	180	3	19454	50	TRPS1,NFIA,RORA
1.110e-02	-4.50	EPHA4 (EPH receptor A4)	protein interactions	2043	180	3	19454	50	FGFR3,CTNNA2,PARD3
1.118e-02	-4.49	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	49	MACF1,GPC5,RYR3,TRPS1
1.120e-02	-4.49	cellular response to growth factor stimulus	biological process	GO:0071363	494	5	18204	50	SOX5,BMPR1B,NFIA,FGFR3,NTRK2
1.120e-02	-4.49	modulation of chemical synaptic transmission	biological process	GO:0050804	494	5	18204	50	ATP1A2,NTRK2,NRXN1,NRG3,SLC1A3
1.129e-02	-4.48	regulation of trans-synaptic signaling	biological process	GO:0099177	495	5	18204	50	SLC1A3,NRG3,NTRK2,ATP1A2,NRXN1
1.132e-02	-4.48	cognition	biological process	GO:0050890	319	4	18204	50	NRXN1,NTRK2,ATP1A2,PTPRZ1
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.145e-02	-4.47	establishment or maintenance of apical/basal cell polarity	biological process	GO:0035088	59	2	18204	50	PARD3B,PARD3
1.145e-02	-4.47	endochondral bone morphogenesis	biological process	GO:0060350	59	2	18204	50	FGFR3,BMPR1B
1.145e-02	-4.47	establishment or maintenance of bipolar cell polarity	biological process	GO:0061245	59	2	18204	50	PARD3,PARD3B
1.145e-02	-4.47	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	8	19454	50	SORBS1,PARD3,NHSL1,MACF1,ABLIM1,PARD3B,PITPNC1,FMN2
1.156e-02	-4.46	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	4	16828	49	GLIS3,FGFR3,PTPRZ1,MACF1
1.160e-02	-4.46	skin-benign_melanocytic_nevus-junctional	COSMIC cancer mutations	skin-benign_melanocytic_nevus-junctional	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-other-normal	COSMIC cancer mutations	urinary_tract-bladder-other-normal	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.160e-02	-4.46	inverted	COSMIC cancer mutations	inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-papilloma-inverted	COSMIC cancer mutations	urinary_tract-bladder-papilloma-inverted	4	1	16828	49	FGFR3
1.165e-02	-4.45	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	17	SLC1A3,ATP1A2
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	NTRK2,FGFR3
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	NFIA,TRPS1
1.182e-02	-4.44	export across plasma membrane	biological process	GO:0140115	60	2	18204	50	SLC4A4,ATP1A2
1.182e-02	-4.44	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	50	NTRK2,ATP1A2
1.182e-02	-4.44	regulation of glucose import	biological process	GO:0046324	60	2	18204	50	SORBS1,SLC1A2
1.184e-02	-4.44	cadherin binding	molecular function	GO:0045296	335	4	18094	48	CTNND2,MACF1,CTNNA2,CDH20
1.186e-02	-4.43	Axon guidance	KEGG pathways	ko04360	174	3	7161	20	ABLIM1,BMPR1B,PARD3
1.186e-02	-4.43	Axon guidance	KEGG pathways	hsa04360	174	3	7161	20	ABLIM1,PARD3,BMPR1B
1.188e-02	-4.43	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	47	16828	49	ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1,SPARCL1,RFX4,NTM,ADCY2,DTNA,SORBS1,NPAS3,CDH20,PITPNC1,ATP1A2,NTRK2,GPM6A,ZNRF3,SLC1A2,ATP13A4,TRPS1,NRG3,SLC4A4,RANBP3L,FBXL7,PTPRZ1,NEBL,PREX2,RYR3,GLIS3,FMN2,GPC5,RORA,PARD3,ABLIM1,NFIA,FGFR3,TNIK,NKAIN3,NHSL1,LSAMP,HIF3A,LRIG1,NRXN1,SOX5,BMPR1B
1.192e-02	-4.43	chemical homeostasis	biological process	GO:0048878	914	7	18204	50	RORA,RYR3,SLC4A4,ATP13A4,SLC1A3,ZBTB20,ATP1A2
1.199e-02	-4.42	Sorb	smart domains	SM00459	3	1	9717	39	SORBS1
1.199e-02	-4.42	PLP	smart domains	SM00002	3	1	9717	39	GPM6A
1.211e-02	-4.41	-	gene3d domains	1.20.58.1060	4	1	14470	44	MACF1
1.216e-02	-4.41	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	49	RYR3,TRPS1,MACF1,GPM6A,GPC5
1.219e-02	-4.41	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	9	16828	49	MACF1,SORBS1,ATP1A2,NTM,PARD3B,ZBTB20,TRPS1,NPAS3,SLC4A4
1.221e-02	-4.41	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	7	16828	49	TRPS1,BMPR1B,NTRK2,MACF1,PREX2,FGFR3,TNIK
1.223e-02	-4.40	monoatomic cation homeostasis	biological process	GO:0055080	505	5	18204	50	RYR3,ATP13A4,SLC1A3,SLC4A4,ATP1A2
1.240e-02	-4.39	cell migration	biological process	GO:0016477	921	7	18204	50	CTNNA2,NRG3,FMN2,CDH20,GPM6A,NTRK2,GPC5
1.240e-02	-4.39	DNA-binding transcription factor activity	molecular function	GO:0003700	1441	9	18094	48	RORA,ZBTB20,SOX5,NPAS3,NFIA,GLIS3,RFX4,HIF3A,TRPS1
1.248e-02	-4.38	HNF1B (HNF1 homeobox B)	protein interactions	6928	188	3	19454	50	NFIA,TRPS1,SOX5
1.249e-02	-4.38	central nervous system neuron differentiation	biological process	GO:0021953	176	3	18204	50	NTRK2,BMPR1B,RORA
1.249e-02	-4.38	back	COSMIC cancer mutations	back	310	4	16828	49	TNIK,FGFR3,PREX2,ATP1A2
1.254e-02	-4.38	Erythroid Transcription Factor GATA-1, subunit A	gene3d domains	3.30.50.10	56	2	14470	44	TRPS1,RORA
1.259e-02	-4.38	regulation of carbohydrate catabolic process	biological process	GO:0043470	62	2	18204	50	ZBTB20,SLC4A4
1.262e-02	-4.37	Ig-like_fold	interpro domains	IPR013783	721	6	18521	50	LSAMP,NTM,FGFR3,PTPRZ1,NTRK2,LRIG1
1.279e-02	-4.36	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	50	NRXN1
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.282e-02	-4.36	regulation of small molecule metabolic process	biological process	GO:0062012	331	4	18204	50	SLC4A4,RORA,SORBS1,ZBTB20
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	MACF1,CTNND2,SFXN5,PARD3B,SLC1A3,ZBTB20,RFX4,SPARCL1,SORBS1,ADCY2,NTM,ATP1A2,NTRK2,PITPNC1,CDH20,NPAS3,SLC1A2,ATP13A4,ZNRF3,GPM6A,PREX2,NEBL,PTPRZ1,FBXL7,RANBP3L,SLC4A4,NRG3,TRPS1,NKAIN3,FGFR3,TNIK,CST3,NFIA,ABLIM1,RORA,PARD3,GLIS3,FMN2,GPC5,RYR3,BMPR1B,SOX5,MSI2,LRIG1,NRXN1,HIF3A,LSAMP,NHSL1
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	NEBL,SORBS1
1.313e-02	-4.33	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	48	16828	49	PREX2,NEBL,RANBP3L,PTPRZ1,FBXL7,TRPS1,NRG3,SLC4A4,SLC1A2,ATP13A4,ZNRF3,GPM6A,SOX5,BMPR1B,HIF3A,LRIG1,NRXN1,MSI2,LSAMP,NHSL1,FGFR3,TNIK,NFIA,ABLIM1,CST3,FMN2,GPC5,GLIS3,PARD3,RORA,RYR3,RFX4,SPARCL1,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,PITPNC1,NTRK2,ATP1A2,CDH20,NPAS3,SORBS1,DTNA,NTM,ADCY2
1.313e-02	-4.33	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	48	16828	49	SPARCL1,RFX4,SLC1A3,ZBTB20,PARD3B,SFXN5,MACF1,CTNND2,NPAS3,CDH20,NTRK2,ATP1A2,PITPNC1,ADCY2,NTM,DTNA,SORBS1,NRG3,SLC4A4,TRPS1,FBXL7,PTPRZ1,RANBP3L,NEBL,PREX2,GPM6A,ZNRF3,ATP13A4,SLC1A2,NHSL1,LSAMP,HIF3A,LRIG1,NRXN1,MSI2,BMPR1B,SOX5,RYR3,PARD3,RORA,FMN2,GPC5,GLIS3,CST3,ABLIM1,NFIA,TNIK,FGFR3
1.313e-02	-4.33	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	48	16828	49	RYR3,GLIS3,FMN2,GPC5,RORA,PARD3,NFIA,ABLIM1,CST3,TNIK,FGFR3,NHSL1,LSAMP,MSI2,NRXN1,HIF3A,LRIG1,SOX5,BMPR1B,GPM6A,ZNRF3,ATP13A4,SLC1A2,TRPS1,NRG3,SLC4A4,RANBP3L,FBXL7,PTPRZ1,NEBL,PREX2,NTM,ADCY2,DTNA,SORBS1,NPAS3,CDH20,PITPNC1,ATP1A2,NTRK2,ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1,SPARCL1,RFX4
1.313e-02	-4.33	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	48	16828	49	PITPNC1,ATP1A2,NTRK2,CDH20,NPAS3,SORBS1,DTNA,NTM,ADCY2,RFX4,SPARCL1,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,SOX5,BMPR1B,MSI2,HIF3A,NRXN1,LRIG1,LSAMP,NHSL1,FGFR3,TNIK,ABLIM1,NFIA,CST3,GLIS3,GPC5,FMN2,RORA,PARD3,RYR3,PREX2,NEBL,RANBP3L,FBXL7,PTPRZ1,TRPS1,NRG3,SLC4A4,SLC1A2,ATP13A4,ZNRF3,GPM6A
1.317e-02	-4.33	classic	COSMIC cancer mutations	classic	14774	48	16828	49	CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SPARCL1,SORBS1,DTNA,NTM,ADCY2,PITPNC1,ATP1A2,NTRK2,CDH20,NPAS3,SLC1A2,ATP13A4,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,FBXL7,PTPRZ1,TRPS1,SLC4A4,NRG3,TNIK,FGFR3,ABLIM1,NFIA,CST3,GLIS3,FMN2,GPC5,PARD3,RORA,RYR3,SOX5,BMPR1B,MSI2,HIF3A,LRIG1,NRXN1,LSAMP,NHSL1
1.317e-02	-4.33	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	3	18094	48	SLC1A3,SLC1A2,SFXN5
1.317e-02	-4.33	upper_leg	COSMIC cancer mutations	upper_leg	880	7	16828	49	NFIA,HIF3A,LRIG1,FGFR3,PREX2,GLIS3,FMN2
1.318e-02	-4.33	main axon	cellular component	GO:0044304	68	2	19108	49	SLC1A2,PARD3
1.320e-02	-4.33	fibroblast growth factor receptor activity	molecular function	GO:0005007	5	1	18094	48	FGFR3
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.320e-02	-4.33	neuroligin family protein binding	molecular function	GO:0097109	5	1	18094	48	NRXN1
1.320e-02	-4.33	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	48	NTRK2
1.321e-02	-4.33	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	23	16828	49	PREX2,PTPRZ1,FBXL7,SPARCL1,TRPS1,ATP13A4,CTNND2,SLC1A3,SOX5,PITPNC1,NTRK2,BMPR1B,LRIG1,HIF3A,MSI2,LSAMP,NPAS3,FGFR3,TNIK,ABLIM1,PARD3,RORA,ADCY2
1.321e-02	-4.33	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	23	16828	49	ATP13A4,CTNND2,SLC1A3,PREX2,SPARCL1,TRPS1,PTPRZ1,FBXL7,ABLIM1,FGFR3,TNIK,ADCY2,RORA,PARD3,MSI2,HIF3A,LRIG1,BMPR1B,NTRK2,PITPNC1,SOX5,NPAS3,LSAMP
1.322e-02	-4.33	monoatomic ion homeostasis	biological process	GO:0050801	515	5	18204	50	SLC4A4,ATP13A4,SLC1A3,RYR3,ATP1A2
1.324e-02	-4.32	PLCH1 (phospholipase C eta 1)	protein interactions	23007	68	2	19454	50	NTRK2,PARD3
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A3,SLC1A2
1.332e-02	-4.32	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	5	16828	49	TNIK,FGFR3,BMPR1B,NTRK2,MACF1
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.332e-02	-4.32	medulla	COSMIC cancer mutations	medulla	14778	48	16828	49	NTM,ADCY2,DTNA,SORBS1,NPAS3,CDH20,PITPNC1,NTRK2,ATP1A2,ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1,SPARCL1,RFX4,RYR3,GPC5,FMN2,GLIS3,RORA,PARD3,NFIA,ABLIM1,CST3,TNIK,FGFR3,NHSL1,LSAMP,LRIG1,NRXN1,HIF3A,MSI2,SOX5,BMPR1B,GPM6A,ZNRF3,SLC1A2,ATP13A4,TRPS1,NRG3,SLC4A4,RANBP3L,FBXL7,PTPRZ1,NEBL,PREX2
1.332e-02	-4.32	cell division	biological process	GO:0051301	516	5	18204	50	FBXL7,PARD3,PARD3B,FMN2,SOX5
1.335e-02	-4.32	camera-type eye development	biological process	GO:0043010	335	4	18204	50	NFIA,GPM6A,NTRK2,BMPR1B
1.336e-02	-4.32	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	48	16828	49	SORBS1,DTNA,NTM,ADCY2,PITPNC1,NTRK2,ATP1A2,CDH20,NPAS3,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SPARCL1,TNIK,FGFR3,ABLIM1,NFIA,CST3,FMN2,GPC5,GLIS3,RORA,PARD3,RYR3,SOX5,BMPR1B,LRIG1,NRXN1,HIF3A,MSI2,LSAMP,NHSL1,SLC1A2,ATP13A4,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,PTPRZ1,FBXL7,TRPS1,NRG3,SLC4A4
1.336e-02	-4.32	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	3	18094	48	SLC1A2,SFXN5,SLC1A3
1.337e-02	-4.31	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	50	SORBS1,FMN2
1.337e-02	-4.31	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	28	FGFR3,NRG3
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	Mtc	interpro domains	IPR004686	5	1	18521	50	SFXN5
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.354e-02	-4.30	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	28	NTRK2
1.363e-02	-4.30	temporoparietal	COSMIC cancer mutations	temporoparietal	61	2	16828	49	RYR3,PARD3
1.366e-02	-4.29	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	50	BMPR1B
1.366e-02	-4.29	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	50	FMN2
1.366e-02	-4.29	otolith morphogenesis	biological process	GO:0032474	5	1	18204	50	LRIG1
1.366e-02	-4.29	citrate transport	biological process	GO:0015746	5	1	18204	50	SFXN5
1.366e-02	-4.29	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	50	NRXN1
1.366e-02	-4.29	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	50	NTRK2
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	tricarboxylic acid transport	biological process	GO:0006842	5	1	18204	50	SFXN5
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	NTM,ADCY2,DTNA,SORBS1,NPAS3,CDH20,NTRK2,ATP1A2,ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1,SPARCL1,RFX4,RYR3,GPC5,FMN2,GLIS3,RORA,PARD3,NFIA,ABLIM1,CST3,TNIK,FGFR3,NKAIN3,NHSL1,LSAMP,LRIG1,HIF3A,NRXN1,MSI2,SOX5,BMPR1B,GPM6A,ZNRF3,ATP13A4,SLC1A2,TRPS1,NRG3,SLC4A4,RANBP3L,FBXL7,PTPRZ1,NEBL,PREX2
1.369e-02	-4.29	SFXNs	pfam domains	PF03820	5	1	17795	49	SFXN5
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.369e-02	-4.29	Vinculin	pfam domains	PF01044	5	1	17795	49	CTNNA2
1.369e-02	-4.29	FOLN	pfam domains	PF09289	5	1	17795	49	SPARCL1
1.377e-02	-4.29	positive regulation of synapse assembly	biological process	GO:0051965	65	2	18204	50	NTRK2,NRXN1
1.384e-02	-4.28	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	17	RORA,NTRK2,SLC1A3
1.387e-02	-4.28	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	6	16828	49	MACF1,PARD3,PARD3B,NRG3,NRXN1,ZBTB20
1.387e-02	-4.28	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	6	16828	49	PARD3,MACF1,PARD3B,NRG3,NRXN1,ZBTB20
1.387e-02	-4.28	non_seminoma	COSMIC cancer mutations	non_seminoma	492	5	16828	49	MACF1,NTRK2,BMPR1B,TNIK,FGFR3
1.389e-02	-4.28	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	50	ZNRF3,CTNND2,MACF1,GPC5
1.390e-02	-4.28	cellular component organization or biogenesis	biological process	GO:0071840	5850	24	18204	50	CTNNA2,SPARCL1,SORBS1,PREX2,RYR3,CDH20,PTPRZ1,NRG3,NRXN1,PARD3,RFX4,NFIA,NEBL,TNIK,CST3,FMN2,CTNND2,PARD3B,MACF1,PITPNC1,GPM6A,ABLIM1,SLC1A2,BMPR1B
1.399e-02	-4.27	cellular component assembly	biological process	GO:0022607	2472	13	18204	50	RYR3,SLC1A2,ABLIM1,GPM6A,SORBS1,FMN2,TNIK,NEBL,NRXN1,PARD3,RFX4,NRG3,CDH20
1.401e-02	-4.27	Neuronal System	REACTOME pathways	R-HSA-112316	349	4	10285	28	NRXN1,SLC1A3,SLC1A2,ADCY2
1.403e-02	-4.27	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	7	16828	49	LRIG1,ABLIM1,SPARCL1,NPAS3,FGFR3,PTPRZ1,ATP1A2
1.404e-02	-4.27	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	4	16828	49	ATP1A2,FMN2,CTNND2,LRIG1
1.407e-02	-4.26	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	5	19454	50	SLC1A3,PARD3,MACF1,FMN2,DTNA
1.412e-02	-4.26	membrane protein complex	cellular component	GO:0098796	1261	8	19108	49	ATP1A2,SLC1A3,CTNNA2,RYR3,SORBS1,BMPR1B,CDH20,SLC1A2
1.418e-02	-4.26	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	49	ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1,SPARCL1,RFX4,NTM,ADCY2,DTNA,SORBS1,NPAS3,CDH20,PITPNC1,NTRK2,ATP1A2,GPM6A,ZNRF3,ATP13A4,SLC1A2,TRPS1,NRG3,SLC4A4,RANBP3L,FBXL7,PTPRZ1,NEBL,PREX2,RYR3,FMN2,GPC5,GLIS3,RORA,PARD3,ABLIM1,NFIA,CST3,TNIK,FGFR3,NKAIN3,NHSL1,LSAMP,LRIG1,NRXN1,HIF3A,SOX5,BMPR1B
1.418e-02	-4.26	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	49	ZNRF3,SLC1A2,ATP13A4,GPM6A,NEBL,PREX2,TRPS1,NRG3,SLC4A4,RANBP3L,FBXL7,PTPRZ1,NFIA,ABLIM1,CST3,FGFR3,TNIK,NKAIN3,RYR3,GPC5,FMN2,GLIS3,PARD3,RORA,LRIG1,NRXN1,HIF3A,SOX5,BMPR1B,NHSL1,LSAMP,SFXN5,CTNND2,MACF1,ZBTB20,SLC1A3,PARD3B,SPARCL1,RFX4,DTNA,SORBS1,NTM,ADCY2,CDH20,PITPNC1,NTRK2,ATP1A2,NPAS3
1.418e-02	-4.26	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	50	SLC1A2,SLC1A3
1.427e-02	-4.25	response to growth factor	biological process	GO:0070848	525	5	18204	50	FGFR3,NTRK2,NFIA,BMPR1B,SOX5
1.433e-02	-4.25	NFIX (nuclear factor I X)	protein interactions	4784	198	3	19454	50	NFIA,TRPS1,SOX5
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	TNIK,GPM6A
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	PARD3,MACF1
1.446e-02	-4.24	ALPHACATENIN	prints domains	PR00805	4	1	5227	19	CTNNA2
1.448e-02	-4.24	skin-arm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-arm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-nevus_sebaceous	COSMIC cancer mutations	skin-neck-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-ear-other-nevus_sebaceous	COSMIC cancer mutations	skin-ear-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-nevus_sebaceous	COSMIC cancer mutations	skin-breast-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.448e-02	-4.24	skin-hand-other-lichenoid_keratosis	COSMIC cancer mutations	skin-hand-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-adnexal_tumour-syringocystadenoma_papilliferum	COSMIC cancer mutations	skin-adnexal_tumour-syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-flank-other-lichenoid_keratosis	COSMIC cancer mutations	skin-flank-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-lichenoid_keratosis	COSMIC cancer mutations	skin-shoulder-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_arm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_arm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-nevus_sebaceous	COSMIC cancer mutations	skin-face-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	lichenoid_keratosis	COSMIC cancer mutations	lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hip-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-hip-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	syringocystadenoma_papilliferum	COSMIC cancer mutations	syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-nevus_sebaceous	COSMIC cancer mutations	skin-shoulder-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-forearm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-lichenoid_keratosis	COSMIC cancer mutations	skin-neck-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-chest-other-lichenoid_keratosis	COSMIC cancer mutations	skin-chest-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-lichenoid_keratosis	COSMIC cancer mutations	skin-face-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-forearm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-scalp-other-nevus_sebaceous	COSMIC cancer mutations	skin-scalp-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-lichenoid_keratosis	COSMIC cancer mutations	skin-breast-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-nevus_sebaceous	COSMIC cancer mutations	skin-lower_back-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-other-lichenoid_keratosis	COSMIC cancer mutations	skin-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.451e-02	-4.23	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	50	ABLIM1,NTRK2,TNIK,PARD3
1.455e-02	-4.23	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	4	ADCY2
1.469e-02	-4.22	NEBULIN	prosite domains	PS51216	4	1	12186	45	NEBL
1.469e-02	-4.22	CTF_NFI_1	prosite domains	PS00349	4	1	12186	45	NFIA
1.469e-02	-4.22	CTF_NFI_2	prosite domains	PS51080	4	1	12186	45	NFIA
1.476e-02	-4.22	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	50	ABLIM1,PARD3
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	TNIK,GPM6A
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	PARD3B,BMPR1B
1.489e-02	-4.21	transcription cis-regulatory region binding	molecular function	GO:0000976	1485	9	18094	48	RFX4,GLIS3,HIF3A,TRPS1,RORA,ZBTB20,SOX5,NPAS3,NFIA
1.493e-02	-4.20	presynapse	cellular component	GO:0098793	569	5	19108	49	NTRK2,SLC1A2,TNIK,GPM6A,NRXN1
1.501e-02	-4.20	actin filament bundle organization	biological process	GO:0061572	68	2	18204	50	FMN2,SORBS1
1.501e-02	-4.20	extraskeletal	COSMIC cancer mutations	extraskeletal	903	7	16828	49	PTPRZ1,ATP1A2,FGFR3,NPAS3,LRIG1,ABLIM1,SPARCL1
1.501e-02	-4.20	transcription regulatory region nucleic acid binding	molecular function	GO:0001067	1487	9	18094	48	NPAS3,SOX5,NFIA,ZBTB20,RORA,HIF3A,RFX4,GLIS3,TRPS1
1.508e-02	-4.19	upper_back	COSMIC cancer mutations	upper_back	328	4	16828	49	GPC5,FGFR3,PARD3B,MACF1
1.512e-02	-4.19	FEV (FEV transcription factor, ETS family member)	protein interactions	54738	202	3	19454	50	TRPS1,SOX5,NFIA
1.529e-02	-4.18	PAR polarity complex	cellular component	GO:0120157	6	1	19108	49	PARD3
1.532e-02	-4.18	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	50	NRXN1
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	FGF6 (fibroblast growth factor 6)	protein interactions	2251	6	1	19454	50	FGFR3
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	RSPO3 (R-spondin 3)	protein interactions	84870	6	1	19454	50	ZNRF3
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	FGF23 (fibroblast growth factor 23)	protein interactions	8074	6	1	19454	50	FGFR3
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	FGF18 (fibroblast growth factor 18)	protein interactions	8817	6	1	19454	50	FGFR3
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.539e-02	-4.17	skin-ankle-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-ankle-malignant_melanoma-acral_lentiginous	330	4	16828	49	NRG3,PREX2,ATP13A4,PARD3
1.549e-02	-4.17	seminoma	COSMIC cancer mutations	seminoma	700	6	16828	49	TRPS1,NTRK2,BMPR1B,PREX2,FGFR3,TNIK
1.550e-02	-4.17	LIM	pfam domains	PF00412	69	2	17795	49	NEBL,ABLIM1
1.552e-02	-4.17	NFIC (nuclear factor I C)	protein interactions	4782	204	3	19454	50	NFIA,TRPS1,SOX5
1.567e-02	-4.16	PDZ	prosite domains	PS50106	143	3	12186	45	PARD3B,PARD3,PREX2
1.572e-02	-4.15	UTRN (utrophin)	protein interactions	7402	205	3	19454	50	DTNA,FGFR3,PARD3
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	NEBL,ABLIM1
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.596e-02	-4.14	NEBU	smart domains	SM00227	4	1	9717	39	NEBL
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	BMPR1B,SOX5,LRIG1,HIF3A,NRXN1,MSI2,LSAMP,NHSL1,NKAIN3,FGFR3,TNIK,CST3,NFIA,ABLIM1,PARD3,RORA,GPC5,FMN2,GLIS3,RYR3,PREX2,NEBL,FBXL7,PTPRZ1,RANBP3L,SLC4A4,NRG3,TRPS1,SLC1A2,ATP13A4,ZNRF3,GPM6A,NTRK2,ATP1A2,CDH20,NPAS3,SORBS1,DTNA,ADCY2,NTM,RFX4,SPARCL1,MACF1,CTNND2,SFXN5,PARD3B,SLC1A3,ZBTB20
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	1	18521	50	NRXN1
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY2
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	large_cell	COSMIC cancer mutations	large_cell	14845	48	16828	49	ZNRF3,ATP13A4,SLC1A2,GPM6A,NEBL,PREX2,SLC4A4,NRG3,TRPS1,FBXL7,PTPRZ1,RANBP3L,CST3,NFIA,ABLIM1,FGFR3,TNIK,RYR3,PARD3,RORA,GLIS3,GPC5,FMN2,MSI2,LRIG1,NRXN1,HIF3A,BMPR1B,SOX5,NHSL1,LSAMP,SFXN5,MACF1,CTNND2,SLC1A3,ZBTB20,PARD3B,SPARCL1,RFX4,DTNA,SORBS1,ADCY2,NTM,CDH20,ATP1A2,NTRK2,PITPNC1,NPAS3
1.614e-02	-4.13	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	4	10285	28	ADCY2,LRIG1,FGFR3,NRG3
1.616e-02	-4.13	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	3	16828	49	GPC5,NRG3,RYR3
1.623e-02	-4.12	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	28	NTRK2
1.629e-02	-4.12	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	50	FGFR3,PARD3,MACF1,BMPR1B
1.637e-02	-4.11	imitative learning	biological process	GO:0098596	6	1	18204	50	NRXN1
1.637e-02	-4.11	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	50	SLC1A3
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	vocal learning	biological process	GO:0042297	6	1	18204	50	NRXN1
1.637e-02	-4.11	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	1	18204	50	NRXN1
1.637e-02	-4.11	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	50	NRG3
1.637e-02	-4.11	fused antrum stage	biological process	GO:0048165	6	1	18204	50	BMPR1B
1.637e-02	-4.11	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	50	FMN2
1.637e-02	-4.11	mammary gland formation	biological process	GO:0060592	6	1	18204	50	NRG3
1.637e-02	-4.11	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	50	CST3
1.640e-02	-4.11	bone development	biological process	GO:0060348	195	3	18204	50	BMPR1B,RANBP3L,FGFR3
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.641e-02	-4.11	SH3_10	pfam domains	PF17902	6	1	17795	49	MACF1
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY2
1.641e-02	-4.11	Syndecan	pfam domains	PF01034	6	1	17795	49	NRXN1
1.641e-02	-4.11	GAS2	pfam domains	PF02187	6	1	17795	49	MACF1
1.641e-02	-4.11	EF-hand_2	pfam domains	PF09068	6	1	17795	49	DTNA
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	RYR3
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	RYR3
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	RYR3
1.641e-02	-4.11	Plectin	pfam domains	PF00681	6	1	17795	49	MACF1
1.641e-02	-4.11	EF-hand_3	pfam domains	PF09069	6	1	17795	49	DTNA
1.664e-02	-4.10	cell-cell adhesion	biological process	GO:0098609	546	5	18204	50	NRXN1,CDH20,CTNNA2,SPARCL1,CTNND2
1.672e-02	-4.09	regulation of ATP metabolic process	biological process	GO:1903578	72	2	18204	50	ZBTB20,SLC4A4
1.675e-02	-4.09	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	50	SORBS1,NHSL1,SLC1A3
1.676e-02	-4.09	ADGRL2 (adhesion G protein-coupled receptor L2)	protein interactions	23266	77	2	19454	50	NTRK2,PARD3
1.694e-02	-4.08	signal transduction	biological process	GO:0007165	4637	20	18204	50	TNIK,FMN2,CTNND2,PARD3,DTNA,NFIA,NRG3,SPARCL1,NTRK2,ADCY2,FGFR3,RYR3,ZNRF3,RORA,BMPR1B,PREX2,ATP1A2,MACF1,PITPNC1,SORBS1
1.696e-02	-4.08	CDK6 (cyclin dependent kinase 6)	protein interactions	1021	211	3	19454	50	FGFR3,SOX5,SORBS1
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP13A4,ATP1A2
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.717e-02	-4.06	Nedd4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	25489	78	2	19454	50	NTRK2,BMPR1B
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	MSI2,SOX5
1.731e-02	-4.06	regulation of developmental process	biological process	GO:0050793	2540	13	18204	50	RANBP3L,TRPS1,MACF1,RORA,SOX5,BMPR1B,FGFR3,NTRK2,PTPRZ1,PARD3,NRXN1,CST3,TNIK
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-Bowen_disease	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-Bowen_disease	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-lower_back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.735e-02	-4.05	skin-adnexal_tumour-trichoblastoma	COSMIC cancer mutations	skin-adnexal_tumour-trichoblastoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-face-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-face-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_leg-epidermal_nevus	COSMIC cancer mutations	skin-lower_leg-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-flank-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-flank-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	collecting_duct_carcinoma	COSMIC cancer mutations	collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-trunk-epidermal_nevus	COSMIC cancer mutations	skin-trunk-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-abdomen-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-abdomen-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-epidermal_nevus	COSMIC cancer mutations	skin-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-epidermal_nevus	COSMIC cancer mutations	skin-head_neck-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	kidney-carcinoma-collecting_duct_carcinoma	COSMIC cancer mutations	kidney-carcinoma-collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-upper_leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-upper_leg-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-actinic_keratosis	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-actinic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	lentiginous_nevus	COSMIC cancer mutations	lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-arm-epidermal_nevus	COSMIC cancer mutations	skin-arm-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-benign_melanocytic_nevus-lentiginous_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus-lentiginous_nevus	6	1	16828	49	FGFR3
1.744e-02	-4.05	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	4	ADCY2
1.744e-02	-4.05	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	4	ADCY2
1.749e-02	-4.05	Muscle contraction	REACTOME pathways	R-HSA-397014	204	3	10285	28	ATP1A2,SORBS1,RYR3
1.759e-02	-4.04	PRDM1 (PR/SET domain 1)	protein interactions	639	79	2	19454	50	TRPS1,NFIA
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	NHSL1,NTRK2,TNIK
1.768e-02	-4.04	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	7	16828	49	MACF1,NTRK2,BMPR1B,ATP1A2,TNIK,FGFR3,PREX2
1.775e-02	-4.03	Thyroid hormone synthesis	KEGG pathways	ko04918	74	2	7161	20	ATP1A2,ADCY2
1.775e-02	-4.03	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	2	7161	20	ATP1A2,ADCY2
1.783e-02	-4.03	Endochondral Ossification	WikiPathways	WP474	65	2	5310	17	SOX5,FGFR3
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	FGF5 (fibroblast growth factor 5)	protein interactions	2250	7	1	19454	50	FGFR3
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.791e-02	-4.02	monoatomic cation transport	biological process	GO:0006812	766	6	18204	50	GPM6A,ATP1A2,RYR3,SLC1A3,ATP13A4,SLC4A4
1.804e-02	-4.01	ATP2B1 (ATPase plasma membrane Ca2+ transporting 1)	protein interactions	490	216	3	19454	50	FGFR3,NTRK2,PARD3
1.805e-02	-4.01	PITRANSFER	prints domains	PR00391	5	1	5227	19	PITPNC1
1.805e-02	-4.01	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	19	SLC4A4
1.811e-02	-4.01	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	44	MACF1
1.811e-02	-4.01	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	44	MACF1
1.811e-02	-4.01	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	44	RYR3
1.820e-02	-4.01	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	20	ADCY2,ATP1A2
1.820e-02	-4.01	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	20	ATP1A2,ADCY2
1.821e-02	-4.01	SMAD binding	molecular function	GO:0046332	78	2	18094	48	RANBP3L,BMPR1B
1.826e-02	-4.00	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	3	19454	50	RORA,ABLIM1,NKAIN3
1.836e-02	-4.00	plasma membrane protein complex	cellular component	GO:0098797	600	5	19108	49	SORBS1,BMPR1B,ATP1A2,CDH20,CTNNA2
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	SOX17 (SRY-box transcription factor 17)	protein interactions	64321	81	2	19454	50	TRPS1,NFIA
1.865e-02	-3.98	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	28	RYR3,ATP13A4,ATP1A2
1.865e-02	-3.98	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	4	18521	50	NTRK2,BMPR1B,TNIK,FGFR3
1.871e-02	-3.98	positive regulation of biological process	biological process	GO:0048518	6326	25	18204	50	SLC1A3,SLC4A4,NTRK2,FGFR3,GPC5,SOX5,ATP1A2,NPAS3,SORBS1,FMN2,TNIK,NRXN1,SFXN5,PARD3,NFIA,GLIS3,RFX4,PTPRZ1,BMPR1B,RORA,SLC1A2,GPM6A,MACF1,RANBP3L,ZBTB20
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP1A2,ATP13A4
1.891e-02	-3.97	FGFR3b ligand binding and activation	REACTOME pathways	R-HSA-190371	7	1	10285	28	FGFR3
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.898e-02	-3.96	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	50	MACF1,NTRK2
1.898e-02	-3.96	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	2	18204	50	NRXN1,ATP1A2
1.898e-02	-3.96	neural retina development	biological process	GO:0003407	77	2	18204	50	NTRK2,GPM6A
1.898e-02	-3.96	BMP signaling pathway	biological process	GO:0030509	77	2	18204	50	NFIA,BMPR1B
1.902e-02	-3.96	sequence-specific double-stranded DNA binding	molecular function	GO:1990837	1547	9	18094	48	RFX4,HIF3A,GLIS3,TRPS1,SOX5,NPAS3,NFIA,RORA,ZBTB20
1.907e-02	-3.96	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	50	FMN2
1.907e-02	-3.96	observational learning	biological process	GO:0098597	7	1	18204	50	NRXN1
1.907e-02	-3.96	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	50	CTNNA2
1.907e-02	-3.96	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	50	PTPRZ1
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	glial cell fate specification	biological process	GO:0021780	7	1	18204	50	NFIA
1.907e-02	-3.96	negative regulation of non-canonical Wnt signaling pathway	biological process	GO:2000051	7	1	18204	50	ZNRF3
1.907e-02	-3.96	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	50	NRG3
1.907e-02	-3.96	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	50	FMN2
1.912e-02	-3.96	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	49	SPARCL1
1.912e-02	-3.96	TGF_beta_GS	pfam domains	PF08515	7	1	17795	49	BMPR1B
1.914e-02	-3.96	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	49	MACF1,FGFR3
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	ATP1A2,SORBS1
1.930e-02	-3.95	SYT1 (synaptotagmin 1)	protein interactions	6857	83	2	19454	50	NRXN1,GPM6A
1.930e-02	-3.95	DNM3 (dynamin 3)	protein interactions	26052	83	2	19454	50	GPM6A,FGFR3
1.930e-02	-3.95	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	50	TRPS1,NFIA
1.938e-02	-3.94	PDZ	smart domains	SM00228	143	3	9717	39	PARD3,PARD3B,PREX2
1.943e-02	-3.94	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	PARD3,FMN2,GPC5,MACF1,SLC1A2,ATP13A4,PREX2
1.943e-02	-3.94	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	PREX2,ATP13A4,SLC1A2,MACF1,GPC5,FMN2,PARD3
1.944e-02	-3.94	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	50	SORBS1,SLC1A2
1.961e-02	-3.93	Rap1 signaling pathway	KEGG pathways	ko04015	210	3	7161	20	ADCY2,FGFR3,PARD3
1.961e-02	-3.93	Rap1 signaling pathway	KEGG pathways	hsa04015	210	3	7161	20	FGFR3,PARD3,ADCY2
1.964e-02	-3.93	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	49	MACF1,FGFR3
1.970e-02	-3.93	LRRNT	smart domains	SM00013	54	2	9717	39	LRIG1,NTRK2
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	FGFR3,NTRK2
1.977e-02	-3.92	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	4	10285	28	ADCY2,NTRK2,FGFR3,NRG3
1.979e-02	-3.92	IG	smart domains	SM00409	394	5	9717	39	FGFR3,LSAMP,NTRK2,NTM,LRIG1
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	GPM6A,ABLIM1,MACF1
2.008e-02	-3.91	KLF3 (KLF transcription factor 3)	protein interactions	51274	225	3	19454	50	NFIA,SOX5,TRPS1
2.018e-02	-3.90	CFAP298 (cilia and flagella associated protein 298)	protein interactions	56683	85	2	19454	50	FMN2,TRPS1
2.021e-02	-3.90	skin-neck-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-neck-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-other-nevus_sebaceous	COSMIC cancer mutations	skin-other-nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-intradermal	COSMIC cancer mutations	skin-benign_melanocytic_nevus-intradermal	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-adnexal_tumour-trichilemmoma	COSMIC cancer mutations	skin-adnexal_tumour-trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	urinary_tract-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma-transitional_cell_carcinoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-compound	COSMIC cancer mutations	skin-benign_melanocytic_nevus-compound	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-chest-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-chest-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-shoulder-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-shoulder-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	nevus_sebaceous	COSMIC cancer mutations	nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-face-adnexal_tumour-malignant_adnexal_tumour	7	1	16828	49	FGFR3
2.021e-02	-3.90	trichilemmoma	COSMIC cancer mutations	trichilemmoma	7	1	16828	49	FGFR3
2.032e-02	-3.90	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	4	ADCY2
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.042e-02	-3.89	eye development	biological process	GO:0001654	381	4	18204	50	GPM6A,NTRK2,NFIA,BMPR1B
2.048e-02	-3.89	IG_LIKE	prosite domains	PS50835	430	5	12186	45	LRIG1,LSAMP,NTRK2,FGFR3,NTM
2.058e-02	-3.88	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	3	10285	28	SLC1A3,SLC1A2,ADCY2
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	GPM6A,SORBS1
2.063e-02	-3.88	FAM171A1 (family with sequence similarity 171 member A1)	protein interactions	221061	86	2	19454	50	NTRK2,PARD3
2.063e-02	-3.88	EGLN1 (egl-9 family hypoxia inducible factor 1)	protein interactions	54583	86	2	19454	50	FGFR3,HIF3A
2.067e-02	-3.88	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	5	16828	49	FGFR3,FMN2,TNIK,BMPR1B,NTRK2
2.072e-02	-3.88	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	44	ABLIM1,NEBL
2.082e-02	-3.87	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	5	16828	49	FGFR3,FMN2,TNIK,NTRK2,BMPR1B
2.087e-02	-3.87	adult locomotory behavior	biological process	GO:0008344	81	2	18204	50	ATP1A2,PREX2
2.087e-02	-3.87	pleura-mesothelioma-epithelial	COSMIC cancer mutations	pleura-mesothelioma-epithelial	362	4	16828	49	LRIG1,ZNRF3,ATP13A4,FMN2
2.092e-02	-3.87	transmembrane transport	biological process	GO:0055085	1264	8	18204	50	ATP13A4,GPM6A,SLC1A3,SLC4A4,RYR3,ATP1A2,SLC1A2,SFXN5
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	SPARCL1,MACF1,RYR3
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.106e-02	-3.86	Immunoglobulins	gene3d domains	2.60.40.10	721	6	14470	44	NTRK2,NTM,LSAMP,FGFR3,PTPRZ1,LRIG1
2.108e-02	-3.86	NHLH1 (nescient helix-loop-helix 1)	protein interactions	4807	87	2	19454	50	NFIA,TRPS1
2.108e-02	-3.86	ZNF608 (zinc finger protein 608)	protein interactions	57507	87	2	19454	50	SOX5,NFIA
2.108e-02	-3.86	Kctd5 (potassium channel tetramerisation domain containing 5)	protein interactions	69259	87	2	19454	50	TRPS1,SLC1A3
2.113e-02	-3.86	visual system development	biological process	GO:0150063	385	4	18204	50	NTRK2,GPM6A,NFIA,BMPR1B
2.115e-02	-3.86	Cys-rich_flank_reg_C	interpro domains	IPR000483	83	2	18521	50	LRIG1,NTRK2
2.117e-02	-3.86	sensory organ development	biological process	GO:0007423	581	5	18204	50	BMPR1B,GPM6A,LRIG1,NTRK2,NFIA
2.123e-02	-3.85	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	46	16828	49	DTNA,SORBS1,ADCY2,CDH20,ATP1A2,NTRK2,PITPNC1,NPAS3,SFXN5,MACF1,CTNND2,SLC1A3,ZBTB20,PARD3B,SPARCL1,NFIA,ABLIM1,NKAIN3,TNIK,FGFR3,RYR3,PARD3,RORA,GLIS3,FMN2,GPC5,MSI2,LRIG1,HIF3A,NRXN1,BMPR1B,SOX5,NHSL1,LSAMP,ZNRF3,SLC1A2,ATP13A4,GPM6A,NEBL,PREX2,NRG3,SLC4A4,TRPS1,PTPRZ1,FBXL7,RANBP3L
2.123e-02	-3.85	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	46	16828	49	NPAS3,PITPNC1,ATP1A2,NTRK2,CDH20,ADCY2,SORBS1,DTNA,SPARCL1,PARD3B,ZBTB20,SLC1A3,CTNND2,MACF1,SFXN5,LSAMP,NHSL1,SOX5,BMPR1B,MSI2,HIF3A,LRIG1,NRXN1,GLIS3,FMN2,GPC5,PARD3,RORA,RYR3,TNIK,FGFR3,NKAIN3,NFIA,ABLIM1,RANBP3L,FBXL7,PTPRZ1,TRPS1,NRG3,SLC4A4,PREX2,NEBL,GPM6A,ATP13A4,SLC1A2,ZNRF3
2.125e-02	-3.85	epithelial	COSMIC cancer mutations	epithelial	364	4	16828	49	ATP13A4,FMN2,LRIG1,ZNRF3
2.125e-02	-3.85	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	44	ATP1A2,ATP13A4
2.126e-02	-3.85	femur	COSMIC cancer mutations	femur	1197	8	16828	49	LRIG1,PTPRZ1,ADCY2,FMN2,GPC5,SLC4A4,NRG3,RYR3
2.126e-02	-3.85	skin-leg-malignant_melanoma	COSMIC cancer mutations	skin-leg-malignant_melanoma	549	5	16828	49	PTPRZ1,ZBTB20,HIF3A,NEBL,NRG3
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY2
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY2
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.140e-02	-3.84	positive regulation of cellular process	biological process	GO:0048522	5719	23	18204	50	GPC5,NTRK2,FGFR3,SLC1A3,SLC4A4,NPAS3,SORBS1,SOX5,PTPRZ1,TNIK,FMN2,PARD3,NRXN1,NFIA,RFX4,GLIS3,MACF1,ZBTB20,RANBP3L,GPM6A,RORA,BMPR1B,SLC1A2
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	BMPR1B,TNIK
2.158e-02	-3.84	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	28	GPC5
2.162e-02	-3.83	ACTIVIN2R	prints domains	PR00653	6	1	5227	19	BMPR1B
2.172e-02	-3.83	regulation of cell junction assembly	biological process	GO:1901888	217	3	18204	50	NTRK2,MACF1,NRXN1
2.177e-02	-3.83	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	50	SLC1A3
2.177e-02	-3.83	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	50	RORA
2.177e-02	-3.83	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	50	NRG3
2.177e-02	-3.83	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	50	CTNNA2
2.177e-02	-3.83	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	50	RORA
2.177e-02	-3.83	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	50	FMN2
2.177e-02	-3.83	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	50	RORA
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.182e-02	-3.82	VHP	pfam domains	PF02209	8	1	17795	49	ABLIM1
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY2
2.196e-02	-3.82	GAR	prosite domains	PS51460	6	1	12186	45	MACF1
2.196e-02	-3.82	GLYPICAN	prosite domains	PS01207	6	1	12186	45	GPC5
2.199e-02	-3.82	SOX10 (SRY-box transcription factor 10)	protein interactions	6663	89	2	19454	50	NFIA,TRPS1
2.203e-02	-3.82	SH3_domain	interpro domains	IPR001452	222	3	18521	50	NEBL,SORBS1,MACF1
2.221e-02	-3.81	sensory system development	biological process	GO:0048880	391	4	18204	50	BMPR1B,NFIA,NTRK2,GPM6A
2.224e-02	-3.81	HMG20A (high mobility group 20A)	protein interactions	10363	234	3	19454	50	NFIA,DTNA,SOX5
2.233e-02	-3.80	peripheral nervous system development	biological process	GO:0007422	84	2	18204	50	NTRK2,PARD3
2.233e-02	-3.80	L-amino acid transport	biological process	GO:0015807	84	2	18204	50	SLC1A2,SLC1A3
2.233e-02	-3.80	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	50	NKAIN3,ATP1A2
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	FMN2,DTNA
2.250e-02	-3.79	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	50	SLC1A3,ATP1A2,NRXN1
2.283e-02	-3.78	oligodendrocyte differentiation	biological process	GO:0048709	85	2	18204	50	PTPRZ1,NTRK2
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.290e-02	-3.78	GUSBP1 (GUSB pseudogene 1)	protein interactions	728411	9	1	19454	50	FGFR3
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	FGFR3
2.292e-02	-3.78	FOXI1 (forkhead box I1)	protein interactions	2299	91	2	19454	50	TRPS1,NFIA
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	NTM,GPM6A
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	SORBS1,TNIK
2.303e-02	-3.77	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	20	ADCY2,ATP1A2
2.306e-02	-3.77	actinic_keratosis	COSMIC cancer mutations	actinic_keratosis	8	1	16828	49	FGFR3
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.306e-02	-3.77	trichoblastoma	COSMIC cancer mutations	trichoblastoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	junctional	COSMIC cancer mutations	junctional	8	1	16828	49	FGFR3
2.318e-02	-3.76	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	3	16828	49	ATP13A4,NTM,SLC4A4
2.319e-02	-3.76	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	28	NRG3,FGFR3
2.320e-02	-3.76	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	4	ADCY2
2.320e-02	-3.76	Bile Acid Indirect Signalling Pathway	SMPDB pathways	SMP0086851	8	1	1369	4	FGFR3
2.325e-02	-3.76	forearm	COSMIC cancer mutations	forearm	81	2	16828	49	PREX2,FGFR3
2.339e-02	-3.76	FNTA (farnesyltransferase, CAAX box, subunit alpha)	protein interactions	2339	92	2	19454	50	FGFR3,TNIK
2.339e-02	-3.76	POTEI (POTE ankyrin domain family member I)	protein interactions	653269	92	2	19454	50	FGFR3,DTNA
2.339e-02	-3.76	SOX9 (SRY-box transcription factor 9)	protein interactions	6662	92	2	19454	50	NFIA,TRPS1
2.346e-02	-3.75	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	7	18204	50	SLC1A3,RYR3,RORA,ADCY2,SORBS1,SLC1A2,ZBTB20
2.385e-02	-3.74	GAS2	smart domains	SM00243	6	1	9717	39	MACF1
2.387e-02	-3.74	MPDZ (multiple PDZ domain crumbs cell polarity complex component)	protein interactions	8777	93	2	19454	50	PARD3,FGFR3
2.387e-02	-3.74	ODR4 (odr-4 GPCR localization factor homolog)	protein interactions	54953	93	2	19454	50	LRIG1,GPM6A
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	ABLIM1,BMPR1B
2.401e-02	-3.73	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	50	PARD3,NTRK2,CTNND2
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	50	CST3
2.407e-02	-3.73	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	44	ABLIM1
2.426e-02	-3.72	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	38	16828	49	CTNND2,ATP13A4,SLC1A2,MACF1,SFXN5,GPM6A,ZBTB20,SLC1A3,PREX2,NEBL,RANBP3L,RFX4,FBXL7,PTPRZ1,TRPS1,SPARCL1,NRG3,FGFR3,TNIK,SORBS1,NKAIN3,ABLIM1,DTNA,GPC5,FMN2,PARD3,ADCY2,RORA,RYR3,SOX5,ATP1A2,NTRK2,NRXN1,LRIG1,CDH20,LSAMP,NHSL1,NPAS3
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	ABLIM1,TNIK
2.435e-02	-3.72	QSER1 (glutamine and serine rich 1)	protein interactions	79832	94	2	19454	50	NFIA,SOX5
2.435e-02	-3.72	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	50	NTRK2,FGFR3
2.435e-02	-3.72	FOXP4 (forkhead box P4)	protein interactions	116113	94	2	19454	50	NFIA,SOX5
2.438e-02	-3.71	postsynapse	cellular component	GO:0098794	646	5	19108	49	CTNND2,ATP1A2,NTRK2,GPM6A,TNIK
2.440e-02	-3.71	cell-cell signaling	biological process	GO:0007267	822	6	18204	50	SLC1A3,NRXN1,SLC1A2,DTNA,NTRK2,FGFR3
2.446e-02	-3.71	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	50	NRXN1
2.446e-02	-3.71	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	50	CTNNA2
2.446e-02	-3.71	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	50	ATP13A4
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.446e-02	-3.71	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	50	CTNNA2
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.452e-02	-3.71	Activin_recp	pfam domains	PF01064	9	1	17795	49	BMPR1B
2.452e-02	-3.71	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	49	RFX4
2.452e-02	-3.71	Band_3_cyto	pfam domains	PF07565	9	1	17795	49	SLC4A4
2.459e-02	-3.71	human chr5p15.1	chromosome location	human chr5p15.1	13	1	26134	50	FBXL7
2.468e-02	-3.70	skeletal system morphogenesis	biological process	GO:0048705	228	3	18204	50	FGFR3,BMPR1B,SOX5
2.470e-02	-3.70	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	28	NRG3,FGFR3
2.487e-02	-3.69	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	2	18204	50	ZBTB20,SORBS1
2.536e-02	-3.67	perineuronal net	cellular component	GO:0072534	10	1	19108	49	PTPRZ1
2.539e-02	-3.67	regulation of purine nucleotide metabolic process	biological process	GO:1900542	90	2	18204	50	ZBTB20,SLC4A4
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.546e-02	-3.67	regulation of biological process	biological process	GO:0050789	12079	40	18204	50	PTPRZ1,NRG3,MSI2,PARD3,SFXN5,NRXN1,NFIA,DTNA,RFX4,GLIS3,TNIK,CST3,CTNND2,FMN2,MACF1,ZBTB20,RANBP3L,PITPNC1,TRPS1,GPM6A,SLC1A2,ZNRF3,RORA,BMPR1B,GPC5,ADCY2,NTRK2,FGFR3,CTNNA2,SPARCL1,NKAIN3,SLC1A3,SLC4A4,SORBS1,NPAS3,HIF3A,PREX2,ATP1A2,RYR3,SOX5
2.547e-02	-3.67	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	7	19454	50	PITPNC1,PARD3B,ABLIM1,MACF1,SORBS1,PARD3,NHSL1
2.557e-02	-3.67	GS	prosite domains	PS51256	7	1	12186	45	BMPR1B
2.568e-02	-3.66	spindle	COSMIC cancer mutations	spindle	386	4	16828	49	MACF1,CTNND2,FGFR3,PREX2
2.573e-02	-3.66	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	28	LSAMP,NTM
2.585e-02	-3.66	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	3	19454	50	TNIK,SOX5,NFIA
2.591e-02	-3.65	in_situ_epithelial_neoplasm	COSMIC cancer mutations	in_situ_epithelial_neoplasm	9	1	16828	49	FGFR3
2.591e-02	-3.65	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	COSMIC cancer mutations	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	9	1	16828	49	FGFR3
2.591e-02	-3.65	compound	COSMIC cancer mutations	compound	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	skin-benign_melanocytic_nevus-congenital	COSMIC cancer mutations	skin-benign_melanocytic_nevus-congenital	9	1	16828	49	FGFR3
2.591e-02	-3.65	Bowen_disease	COSMIC cancer mutations	Bowen_disease	9	1	16828	49	FGFR3
2.591e-02	-3.65	epidermal_nevus	COSMIC cancer mutations	epidermal_nevus	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-other-seborrhoeic_keratosis	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.592e-02	-3.65	regulation of nucleotide metabolic process	biological process	GO:0006140	91	2	18204	50	ZBTB20,SLC4A4
2.592e-02	-3.65	response to BMP	biological process	GO:0071772	91	2	18204	50	BMPR1B,NFIA
2.592e-02	-3.65	cellular response to BMP stimulus	biological process	GO:0071773	91	2	18204	50	NFIA,BMPR1B
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	4	ADCY2
2.607e-02	-3.65	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	4	ADCY2
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	4	ADCY2
2.607e-02	-3.65	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	4	ADCY2
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	4	ADCY2
2.621e-02	-3.64	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	44	16828	49	GPM6A,ATP13A4,SLC1A2,ZNRF3,RANBP3L,PTPRZ1,FBXL7,TRPS1,SLC4A4,NRG3,PREX2,NEBL,FMN2,GPC5,GLIS3,RORA,PARD3,RYR3,TNIK,FGFR3,NKAIN3,CST3,LSAMP,NHSL1,SOX5,BMPR1B,HIF3A,LRIG1,NRXN1,PARD3B,ZBTB20,SLC1A3,CTNND2,MACF1,SFXN5,RFX4,SPARCL1,NTM,ADCY2,SORBS1,NPAS3,NTRK2,ATP1A2,CDH20
2.622e-02	-3.64	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	48	ATP13A4
2.622e-02	-3.64	neurotrophin binding	molecular function	GO:0043121	10	1	18094	48	NTRK2
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	GPM6A,LSAMP
2.637e-02	-3.64	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	50	ADCY2,FGFR3,PREX2,ATP1A2,RYR3,TNIK
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.646e-02	-3.63	human chr2p13.2	chromosome location	human chr2p13.2	14	1	26134	50	SFXN5
2.654e-02	-3.63	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	49	SLC4A4,FGFR3,PREX2,FMN2,PARD3B
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.676e-02	-3.62	inorganic cation transmembrane transport	biological process	GO:0098662	618	5	18204	50	RYR3,SLC4A4,SLC1A3,ATP1A2,GPM6A
2.678e-02	-3.62	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	28	NRG3,FGFR3
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	TRPS1,SOX5
2.683e-02	-3.62	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	48	ATP13A4,ATP1A2
2.690e-02	-3.62	chemical synaptic transmission	biological process	GO:0007268	415	4	18204	50	DTNA,SLC1A2,NRXN1,SLC1A3
2.690e-02	-3.62	anterograde trans-synaptic signaling	biological process	GO:0098916	415	4	18204	50	DTNA,NRXN1,SLC1A2,SLC1A3
2.690e-02	-3.62	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	28	ADCY2
2.690e-02	-3.62	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	28	NRG3
2.690e-02	-3.62	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	28	SLC4A4
2.690e-02	-3.62	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	28	FGFR3
2.693e-02	-3.61	CRX (cone-rod homeobox)	protein interactions	1406	252	3	19454	50	NFIA,SOX5,TRPS1
2.698e-02	-3.61	double-stranded DNA binding	molecular function	GO:0003690	1643	9	18094	48	TRPS1,GLIS3,HIF3A,RFX4,ZBTB20,RORA,NFIA,NPAS3,SOX5
2.714e-02	-3.61	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	1	18204	50	NRXN1
2.714e-02	-3.61	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	50	NRG3
2.714e-02	-3.61	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	50	ADCY2
2.714e-02	-3.61	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	50	NTRK2
2.714e-02	-3.61	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	50	NRG3
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	50	NRXN1
2.714e-02	-3.61	otolith development	biological process	GO:0048840	10	1	18204	50	LRIG1
2.714e-02	-3.61	retinal rod cell development	biological process	GO:0046548	10	1	18204	50	NTRK2
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	50	NRXN1
2.714e-02	-3.61	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	50	NTRK2
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	NTRK2,FGFR3
2.719e-02	-3.60	response to organic cyclic compound	biological process	GO:0014070	843	6	18204	50	ATP1A2,ADCY2,SLC1A2,SLC1A3,RORA,RYR3
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	RYR3
2.720e-02	-3.60	HCO3_cotransp	pfam domains	PF00955	10	1	17795	49	SLC4A4
2.731e-02	-3.60	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	50	NRXN1,ABLIM1
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	ATP1A2,GPM6A
2.756e-02	-3.59	muscle contraction	biological process	GO:0006936	238	3	18204	50	RYR3,DTNA,ATP1A2
2.776e-02	-3.58	DYNLL2 (dynein light chain LC8-type 2)	protein interactions	140735	255	3	19454	50	NHSL1,TRPS1,NFIA
2.777e-02	-3.58	PLEC	smart domains	SM00250	7	1	9717	39	MACF1
2.777e-02	-3.58	GS	smart domains	SM00467	7	1	9717	39	BMPR1B
2.781e-02	-3.58	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	50	CTNNA2,FGFR3
2.784e-02	-3.58	sequence-specific DNA binding	molecular function	GO:0043565	1652	9	18094	48	RFX4,HIF3A,GLIS3,TRPS1,ZBTB20,RORA,NPAS3,SOX5,NFIA
2.786e-02	-3.58	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	49	PTPRZ1
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	GAL3ST1 (galactose-3-O-sulfotransferase 1)	protein interactions	9514	11	1	19454	50	LRIG1
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	CCDC17 (coiled-coil domain containing 17)	protein interactions	149483	11	1	19454	50	FGFR3
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.792e-02	-3.58	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	1	19454	50	ADCY2
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	50	NRXN1
2.820e-02	-3.57	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	45	ABLIM1,NEBL
2.820e-02	-3.57	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	45	NEBL,ABLIM1
2.831e-02	-3.56	ankle	COSMIC cancer mutations	ankle	398	4	16828	49	PARD3,PREX2,ATP13A4,NRG3
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.865e-02	-3.55	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	46	16828	49	ATP1A2,NTRK2,PITPNC1,CDH20,NPAS3,SORBS1,DTNA,ADCY2,NTM,RFX4,SPARCL1,MACF1,CTNND2,SFXN5,PARD3B,SLC1A3,ZBTB20,BMPR1B,SOX5,MSI2,HIF3A,NRXN1,LRIG1,LSAMP,TNIK,FGFR3,NFIA,ABLIM1,RORA,PARD3,GLIS3,GPC5,FMN2,RYR3,PREX2,NEBL,FBXL7,PTPRZ1,RANBP3L,NRG3,SLC4A4,TRPS1,SLC1A2,ATP13A4,ZNRF3,GPM6A
2.872e-02	-3.55	cellular component biogenesis	biological process	GO:0044085	2716	13	18204	50	CDH20,NRG3,PARD3,NRXN1,RFX4,NEBL,TNIK,FMN2,GPM6A,SORBS1,ABLIM1,SLC1A2,RYR3
2.873e-02	-3.55	GATAZNFINGER	prints domains	PR00619	8	1	5227	19	TRPS1
2.875e-02	-3.55	cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	kidney-carcinoma-renal_cell_carcinoma_unclassified	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.875e-02	-3.55	lung-carcinoma-pleomorphic_carcinoma	COSMIC cancer mutations	lung-carcinoma-pleomorphic_carcinoma	10	1	16828	49	FGFR3
2.875e-02	-3.55	renal_cell_carcinoma_unclassified	COSMIC cancer mutations	renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	intradermal	COSMIC cancer mutations	intradermal	10	1	16828	49	FGFR3
2.876e-02	-3.55	metal ion transport	biological process	GO:0030001	630	5	18204	50	RYR3,SLC1A3,SLC4A4,GPM6A,ATP1A2
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.880e-02	-3.55	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	48	NRXN1
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	BMPR1B,GPM6A
2.884e-02	-3.55	ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)	protein interactions	25921	103	2	19454	50	NTRK2,PARD3
2.889e-02	-3.54	MARK2 (microtubule affinity regulating kinase 2)	protein interactions	2011	259	3	19454	50	PARD3,DTNA,PARD3B
2.889e-02	-3.54	Circadian entrainment	KEGG pathways	hsa04713	96	2	7161	20	ADCY2,RYR3
2.889e-02	-3.54	Circadian entrainment	KEGG pathways	ko04713	96	2	7161	20	RYR3,ADCY2
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A3,SLC1A2
2.893e-02	-3.54	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	4	ADCY2
2.917e-02	-3.53	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	50	SLC1A3,SLC1A2
2.917e-02	-3.53	nerve development	biological process	GO:0021675	97	2	18204	50	LRIG1,SLC1A3
2.917e-02	-3.53	HP	prosite domains	PS51089	8	1	12186	45	ABLIM1
2.917e-02	-3.53	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	45	TRPS1
2.931e-02	-3.53	RanBP1-like	interpro domains	IPR045255	11	1	18521	50	RANBP3L
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.931e-02	-3.53	Ran_bind_dom	interpro domains	IPR000156	11	1	18521	50	RANBP3L
2.968e-02	-3.52	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	50	NRG3,FGFR3,SORBS1,NTRK2
2.980e-02	-3.51	organic substance transport	biological process	GO:0071702	1881	10	18204	50	SLC4A4,FMN2,SLC1A3,SLC1A2,SFXN5,ATP13A4,RANBP3L,PITPNC1,MACF1,NTRK2
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.981e-02	-3.51	polyamine transport	biological process	GO:0015846	11	1	18204	50	ATP13A4
2.981e-02	-3.51	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	50	BMPR1B
2.981e-02	-3.51	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	50	NRG3
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	50	NRG3
2.981e-02	-3.51	ectodermal placode formation	biological process	GO:0060788	11	1	18204	50	NRG3
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	glutamate secretion	biological process	GO:0014047	11	1	18204	50	NTRK2
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.984e-02	-3.51	cell motility	biological process	GO:0048870	1101	7	18204	50	NTRK2,GPM6A,GPC5,FMN2,CTNNA2,NRG3,CDH20
2.988e-02	-3.51	BEND3 (BEN domain containing 3)	protein interactions	57673	105	2	19454	50	TRPS1,TNIK
2.988e-02	-3.51	Ran_BP1	pfam domains	PF00638	11	1	17795	49	RANBP3L
2.988e-02	-3.51	PAS_11	pfam domains	PF14598	11	1	17795	49	HIF3A
2.988e-02	-3.51	LRRCT	pfam domains	PF01463	11	1	17795	49	LRIG1
2.999e-02	-3.51	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	50	NTRK2,MACF1,PTPRZ1
3.000e-02	-3.51	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	44	SLC4A4
3.010e-02	-3.50	SH3 Domains	gene3d domains	2.30.30.40	223	3	14470	44	MACF1,SORBS1,NEBL
3.028e-02	-3.50	bone morphogenesis	biological process	GO:0060349	99	2	18204	50	BMPR1B,FGFR3
3.034e-02	-3.50	response to wounding	biological process	GO:0009611	431	4	18204	50	SLC1A3,SLC1A2,MACF1,NFIA
3.035e-02	-3.49	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	49	PTPRZ1
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.040e-02	-3.49	USP6NL (USP6 N-terminal like)	protein interactions	9712	106	2	19454	50	NTRK2,PARD3
3.042e-02	-3.49	IL15 (interleukin 15)	protein interactions	3600	12	1	19454	50	LRIG1
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	LGR5 (leucine rich repeat containing G protein-coupled receptor 5)	protein interactions	8549	12	1	19454	50	ZNRF3
3.042e-02	-3.49	Pard6b (par-6 family cell polarity regulator beta)	protein interactions	58220	12	1	19454	50	PARD3
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.079e-02	-3.48	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	50	ATP1A2,RYR3,SLC1A3,ATP13A4
3.114e-02	-3.47	Leu-rich_rpt	interpro domains	IPR001611	254	3	18521	50	NTRK2,LRIG1,FBXL7
3.138e-02	-3.46	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	48	ADCY2
3.142e-02	-3.46	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	50	RORA,SORBS1
3.147e-02	-3.46	EN1 (engrailed homeobox 1)	protein interactions	2019	108	2	19454	50	TRPS1,NFIA
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	MSI2,RYR3
3.147e-02	-3.46	PAX8 (paired box 8)	protein interactions	7849	108	2	19454	50	NFIA,TRPS1
3.149e-02	-3.46	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	50	ABLIM1,FMN2,NHSL1,MACF1
3.151e-02	-3.46	VCL (vinculin)	protein interactions	7414	268	3	19454	50	SORBS1,MACF1,NEBL
3.158e-02	-3.46	congenital	COSMIC cancer mutations	congenital	11	1	16828	49	FGFR3
3.158e-02	-3.46	seborrhoeic_keratosis	COSMIC cancer mutations	seborrhoeic_keratosis	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.158e-02	-3.46	skin-neck-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-neck-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	pleomorphic_carcinoma	COSMIC cancer mutations	pleomorphic_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	kidney-other-oncocytoma	COSMIC cancer mutations	kidney-other-oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	prostate-hyperplasia	COSMIC cancer mutations	prostate-hyperplasia	11	1	16828	49	FGFR3
3.158e-02	-3.46	oncocytoma	COSMIC cancer mutations	oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-scalp-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.167e-02	-3.45	VHP	smart domains	SM00153	8	1	9717	39	ABLIM1
3.179e-02	-3.45	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	4	RORA
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	RYR3,GPC5,FMN2,GLIS3,RORA,PARD3,NFIA,ABLIM1,CST3,FGFR3,TNIK,NHSL1,LSAMP,NRXN1,HIF3A,LRIG1,MSI2,SOX5,BMPR1B,GPM6A,ZNRF3,ATP13A4,SLC1A2,TRPS1,NRG3,SLC4A4,RANBP3L,FBXL7,PTPRZ1,NEBL,PREX2,NTM,ADCY2,DTNA,SORBS1,NPAS3,CDH20,PITPNC1,NTRK2,ATP1A2,ZBTB20,SLC1A3,PARD3B,SFXN5,CTNND2,MACF1,SPARCL1,RFX4
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	ZNRF3,ATP13A4,SLC1A2,GPM6A,NEBL,PREX2,SLC4A4,NRG3,TRPS1,PTPRZ1,FBXL7,RANBP3L,CST3,NFIA,ABLIM1,TNIK,FGFR3,RYR3,PARD3,RORA,FMN2,GPC5,GLIS3,HIF3A,LRIG1,NRXN1,MSI2,BMPR1B,SOX5,NHSL1,LSAMP,SFXN5,MACF1,CTNND2,SLC1A3,ZBTB20,PARD3B,SPARCL1,RFX4,DTNA,SORBS1,ADCY2,NTM,CDH20,NTRK2,ATP1A2,PITPNC1,NPAS3
3.220e-02	-3.44	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	28	GPC5
3.220e-02	-3.44	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	28	HIF3A
3.220e-02	-3.44	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	28	GPC5
3.220e-02	-3.44	FGFR3 mutant receptor activation	REACTOME pathways	R-HSA-2033514	12	1	10285	28	FGFR3
3.220e-02	-3.44	Signaling by activated point mutants of FGFR3	REACTOME pathways	R-HSA-1839130	12	1	10285	28	FGFR3
3.248e-02	-3.43	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	50	BMPR1B
3.248e-02	-3.43	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	50	BMPR1B
3.248e-02	-3.43	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	50	CST3
3.248e-02	-3.43	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	50	CST3
3.248e-02	-3.43	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	50	SLC1A2
3.250e-02	-3.43	DNA-binding transcription repressor activity, RNA polymerase II-specific	molecular function	GO:0001227	263	3	18094	48	ZBTB20,GLIS3,TRPS1
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	PARD3B,BMPR1B
3.256e-02	-3.42	MH1	pfam domains	PF03165	12	1	17795	49	NFIA
3.264e-02	-3.42	functioning	COSMIC cancer mutations	functioning	1803	10	16828	49	ZBTB20,NRG3,NHSL1,FMN2,PTPRZ1,RFX4,ZNRF3,SOX5,SLC1A2,NTRK2
3.264e-02	-3.42	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	10	16828	49	NRG3,NHSL1,ZBTB20,RFX4,PTPRZ1,FMN2,ZNRF3,NTRK2,SLC1A2,SOX5
3.270e-02	-3.42	nervous system process	biological process	GO:0050877	1376	8	18204	50	NTRK2,LRIG1,ABLIM1,PTPRZ1,CTNNA2,NRXN1,ATP1A2,SLC1A3
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	ATP1A2,RORA
3.276e-02	-3.42	CYSTATIN	prosite domains	PS00287	9	1	12186	45	CST3
3.276e-02	-3.42	RFX_DBD	prosite domains	PS51526	9	1	12186	45	RFX4
3.278e-02	-3.42	LIM	smart domains	SM00132	71	2	9717	39	ABLIM1,NEBL
3.279e-02	-3.42	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	13	16828	49	NRG3,TRPS1,PTPRZ1,NRXN1,LRIG1,PREX2,SLC1A3,ADCY2,PARD3,RORA,FMN2,GPC5,MACF1
3.291e-02	-3.41	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	50	NRXN1
3.291e-02	-3.41	PLPPR4 (phospholipid phosphatase related 4)	protein interactions	9890	13	1	19454	50	ZNRF3
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.291e-02	-3.41	JAM2 (junctional adhesion molecule 2)	protein interactions	58494	13	1	19454	50	PARD3
3.302e-02	-3.41	FLOT2 (flotillin 2)	protein interactions	2319	273	3	19454	50	NTRK2,SOX5,PARD3
3.308e-02	-3.41	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	50	CTNNA2,TNIK,NTRK2,MACF1
3.310e-02	-3.41	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	46	16828	49	TNIK,FGFR3,NFIA,ABLIM1,FMN2,GPC5,GLIS3,PARD3,RORA,RYR3,SOX5,BMPR1B,LRIG1,NRXN1,HIF3A,MSI2,LSAMP,ATP13A4,SLC1A2,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,FBXL7,PTPRZ1,TRPS1,SLC4A4,NRG3,SORBS1,DTNA,NTM,ADCY2,PITPNC1,NTRK2,ATP1A2,CDH20,NPAS3,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SPARCL1
3.310e-02	-3.41	bladder	COSMIC cancer mutations	bladder	14112	46	16828	49	SLC1A3,ZBTB20,PARD3B,SFXN5,MACF1,CTNND2,SPARCL1,RFX4,ADCY2,NTM,DTNA,SORBS1,NPAS3,CDH20,ATP1A2,NTRK2,PITPNC1,GPM6A,ZNRF3,ATP13A4,SLC1A2,SLC4A4,NRG3,TRPS1,FBXL7,PTPRZ1,RANBP3L,NEBL,PREX2,RYR3,PARD3,RORA,GLIS3,FMN2,GPC5,NFIA,ABLIM1,FGFR3,TNIK,LSAMP,MSI2,LRIG1,HIF3A,NRXN1,BMPR1B,SOX5
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	MACF1,TRPS1
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	ZNRF3,DTNA
3.425e-02	-3.37	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	50	NEBL,GPM6A,SLC1A3
3.432e-02	-3.37	oogenesis	biological process	GO:0048477	106	2	18204	50	BMPR1B,FMN2
3.440e-02	-3.37	skin-face-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-basal_cell_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-benign_melanocytic_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.440e-02	-3.37	cervix-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	cervix-carcinoma-mixed_adenosquamous_carcinoma	12	1	16828	49	FGFR3
3.457e-02	-3.36	TJP2 (tight junction protein 2)	protein interactions	9414	278	3	19454	50	SORBS1,PARD3,NEBL
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	ATP1A2,SORBS1
3.464e-02	-3.36	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	4	ATP1A2
3.464e-02	-3.36	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	4	ATP1A2
3.474e-02	-3.36	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	50	ZBTB20,MACF1
3.484e-02	-3.36	Phospholipase C-mediated cascade; FGFR3	REACTOME pathways	R-HSA-5654227	13	1	10285	28	FGFR3
3.484e-02	-3.36	FGFR3c ligand binding and activation	REACTOME pathways	R-HSA-190372	13	1	10285	28	FGFR3
3.484e-02	-3.36	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	28	NRG3
3.484e-02	-3.36	FGFR3 ligand binding and activation	REACTOME pathways	R-HSA-190239	13	1	10285	28	FGFR3
3.487e-02	-3.36	RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	GO:0000978	1180	7	18094	48	NFIA,SOX5,ZBTB20,RORA,GLIS3,HIF3A,RFX4
3.514e-02	-3.35	prepulse inhibition	biological process	GO:0060134	13	1	18204	50	CTNNA2
3.514e-02	-3.35	ectodermal placode development	biological process	GO:0071696	13	1	18204	50	NRG3
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	50	NRXN1
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	50	RORA
3.514e-02	-3.35	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	50	RORA
3.514e-02	-3.35	glial cell fate commitment	biological process	GO:0021781	13	1	18204	50	NFIA
3.530e-02	-3.34	DTNA (dystrobrevin alpha)	protein interactions	1837	115	2	19454	50	PARD3,NTRK2
3.530e-02	-3.34	TBXT (T-box transcription factor T)	protein interactions	6862	115	2	19454	50	NFIA,TRPS1
3.530e-02	-3.34	CDH2 (cadherin 2)	protein interactions	1000	115	2	19454	50	PARD3,CTNND2
3.533e-02	-3.34	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	50	TNIK,CTNNA2,MACF1,NTRK2,GPM6A
3.538e-02	-3.34	DNA-binding transcription repressor activity	molecular function	GO:0001217	272	3	18094	48	TRPS1,GLIS3,ZBTB20
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	SYT5 (synaptotagmin 5)	protein interactions	6861	14	1	19454	50	NRXN1
3.540e-02	-3.34	PLXNA4 (plexin A4)	protein interactions	91584	14	1	19454	50	GPM6A
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	ZBTB20
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	ZNRF3
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	50	CST3
3.540e-02	-3.34	FGF7 (fibroblast growth factor 7)	protein interactions	2252	14	1	19454	50	FGFR3
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.553e-02	-3.34	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	48	16828	49	SORBS1,DTNA,NTM,ADCY2,PITPNC1,NTRK2,ATP1A2,CDH20,NPAS3,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SPARCL1,TNIK,FGFR3,NKAIN3,NFIA,ABLIM1,GPC5,FMN2,GLIS3,PARD3,RORA,RYR3,SOX5,BMPR1B,LRIG1,HIF3A,NRXN1,MSI2,LSAMP,NHSL1,ATP13A4,SLC1A2,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,PTPRZ1,FBXL7,TRPS1,SLC4A4,NRG3
3.556e-02	-3.34	FOLN	smart domains	SM00274	9	1	9717	39	SPARCL1
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.575e-02	-3.33	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	49	LRIG1,FGFR3,TNIK,BMPR1B,PTPRZ1,NTRK2
3.575e-02	-3.33	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	49	LRIG1,NTRK2,PTPRZ1,BMPR1B,TNIK,FGFR3
3.576e-02	-3.33	LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)	protein interactions	55004	714	5	19454	50	PARD3,SLC1A3,TNIK,DTNA,FMN2
3.577e-02	-3.33	SH3DOMAIN	prints domains	PR00452	83	2	5227	19	SORBS1,NEBL
3.579e-02	-3.33	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	19	SLC4A4
3.586e-02	-3.33	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	2	19454	50	SPARCL1,MACF1
3.590e-02	-3.33	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	44	CTNNA2
3.593e-02	-3.33	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	6	16828	49	FMN2,GLIS3,PREX2,HIF3A,LRIG1,NFIA
3.612e-02	-3.32	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	49	FGFR3,TNIK,NTRK2,BMPR1B
3.612e-02	-3.32	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	49	NTRK2,BMPR1B,TNIK,FGFR3
3.612e-02	-3.32	postsynapse organization	biological process	GO:0099173	109	2	18204	50	NRXN1,CTNND2
3.620e-02	-3.32	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	50	ZNRF3,CTNND2,GPC5
3.623e-02	-3.32	regulation of cellular process	biological process	GO:0050794	11468	38	18204	50	BMPR1B,RORA,ZNRF3,SLC1A2,GPM6A,MACF1,ZBTB20,RANBP3L,PITPNC1,TRPS1,FMN2,CTNND2,TNIK,CST3,NRXN1,PARD3,DTNA,RFX4,GLIS3,NFIA,PTPRZ1,NRG3,MSI2,RYR3,SOX5,ATP1A2,PREX2,HIF3A,NPAS3,SORBS1,SLC1A3,SLC4A4,CTNNA2,SPARCL1,ADCY2,NTRK2,FGFR3,GPC5
3.633e-02	-3.32	MIR	prosite domains	PS50919	10	1	12186	45	RYR3
3.642e-02	-3.31	ELK3 (ETS transcription factor ELK3)	protein interactions	2004	117	2	19454	50	NFIA,TRPS1
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	PARD3,PARD3B,PITPNC1
3.672e-02	-3.30	positive regulation of cell junction assembly	biological process	GO:1901890	110	2	18204	50	NRXN1,NTRK2
3.678e-02	-3.30	bHLH_dom	interpro domains	IPR011598	112	2	18521	50	HIF3A,NPAS3
3.678e-02	-3.30	HLH_DNA-bd_sf	interpro domains	IPR036638	112	2	18521	50	HIF3A,NPAS3
3.684e-02	-3.30	positive regulation of cell differentiation	biological process	GO:0045597	906	6	18204	50	MACF1,RANBP3L,NTRK2,SOX5,PTPRZ1,BMPR1B
3.715e-02	-3.29	Neurexin-like	interpro domains	IPR003585	14	1	18521	50	NRXN1
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	endometrium-ovary-endometriosis	COSMIC cancer mutations	endometrium-ovary-endometriosis	13	1	16828	49	FGFR3
3.721e-02	-3.29	cervix-carcinoma-adenocarcinoma	COSMIC cancer mutations	cervix-carcinoma-adenocarcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-back-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-back-carcinoma-basal_cell_carcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	Brenner_tumour	COSMIC cancer mutations	Brenner_tumour	13	1	16828	49	FGFR3
3.747e-02	-3.28	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	28	NRG3
3.747e-02	-3.28	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	28	ABLIM1
3.749e-02	-3.28	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	4	ATP1A2
3.756e-02	-3.28	ANKRD26 (ankyrin repeat domain containing 26)	protein interactions	22852	119	2	19454	50	PARD3,NTRK2
3.771e-02	-3.28	protein localization to membrane	biological process	GO:0072657	462	4	18204	50	PARD3,MACF1,NRXN1,TNIK
3.779e-02	-3.28	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	17	BMPR1B
3.779e-02	-3.28	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	17	RYR3
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	cellular response to forskolin	biological process	GO:1904322	14	1	18204	50	ADCY2
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	response to forskolin	biological process	GO:1904321	14	1	18204	50	ADCY2
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	FGF9 (fibroblast growth factor 9)	protein interactions	2254	15	1	19454	50	FGFR3
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	GATA	pfam domains	PF00320	14	1	17795	49	TRPS1
3.794e-02	-3.27	rhythmic process	biological process	GO:0048511	270	3	18204	50	RORA,BMPR1B,NTRK2
3.796e-02	-3.27	regulation of membrane potential	biological process	GO:0042391	463	4	18204	50	SLC4A4,NRXN1,NTRK2,ATP1A2
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	SORBS1,NEBL,ABLIM1
3.814e-02	-3.27	cis-regulatory region sequence-specific DNA binding	molecular function	GO:0000987	1203	7	18094	48	NFIA,SOX5,ZBTB20,RORA,RFX4,HIF3A,GLIS3
3.851e-02	-3.26	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	49	NTRK2,BMPR1B,FGFR3,TNIK
3.855e-02	-3.26	calcium channel activity	molecular function	GO:0005262	117	2	18094	48	RYR3,GPM6A
3.871e-02	-3.25	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	4	10285	28	FGFR3,NRG3,ADCY2,NTRK2
3.873e-02	-3.25	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	50	MACF1,GPM6A,NTRK2,TNIK,CTNNA2
3.908e-02	-3.24	filamin binding	molecular function	GO:0031005	15	1	18094	48	NEBL
3.908e-02	-3.24	tropomyosin binding	molecular function	GO:0005523	15	1	18094	48	NEBL
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.918e-02	-3.24	negative regulation of protein catabolic process	biological process	GO:0042177	114	2	18204	50	FMN2,CST3
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	DTNA,NHSL1
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.944e-02	-3.23	MIR	smart domains	SM00472	10	1	9717	39	RYR3
3.947e-02	-3.23	pulmonary_blastoma	COSMIC cancer mutations	pulmonary_blastoma	648	5	16828	49	NEBL,TRPS1,BMPR1B,NTM,ATP13A4
3.947e-02	-3.23	pleura-pulmonary_blastoma	COSMIC cancer mutations	pleura-pulmonary_blastoma	648	5	16828	49	ATP13A4,NTM,BMPR1B,TRPS1,NEBL
3.970e-02	-3.23	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	5	16828	49	MACF1,PREX2,FGFR3,TNIK,ABLIM1
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.988e-02	-3.22	PAX7 (paired box 7)	protein interactions	5081	123	2	19454	50	TRPS1,NFIA
3.989e-02	-3.22	RANBD1	prosite domains	PS50196	11	1	12186	45	RANBP3L
3.989e-02	-3.22	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	45	TRPS1
3.989e-02	-3.22	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	45	NTRK2
4.002e-02	-3.22	soft_tissue-small_round_cell_tumour	COSMIC cancer mutations	soft_tissue-small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	small_round_cell_tumour	COSMIC cancer mutations	small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	in_situ_neoplasm	COSMIC cancer mutations	in_situ_neoplasm	14	1	16828	49	FGFR3
4.002e-02	-3.22	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	14	1	16828	49	FGFR3
4.002e-02	-3.22	endometriosis	COSMIC cancer mutations	endometriosis	14	1	16828	49	FGFR3
4.009e-02	-3.22	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	28	ADCY2
4.009e-02	-3.22	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	28	ADCY2
4.009e-02	-3.22	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	28	NRG3
4.023e-02	-3.21	Prot_kinase_dom	interpro domains	IPR000719	480	4	18521	50	FGFR3,TNIK,BMPR1B,NTRK2
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.035e-02	-3.21	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	50	NRXN1
4.035e-02	-3.21	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	50	NRXN1
4.035e-02	-3.21	HLA-H (major histocompatibility complex, class I, H (pseudogene))	protein interactions	3136	16	1	19454	50	FGFR3
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	ZNRF3
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	SYT4 (synaptotagmin 4)	protein interactions	6860	16	1	19454	50	NRXN1
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	CTSK (cathepsin K)	protein interactions	1513	16	1	19454	50	FGFR3
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	MACF1
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	NBL1 (NBL1, DAN family BMP antagonist)	protein interactions	4681	16	1	19454	50	LRIG1
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.043e-02	-3.21	synapse maturation	biological process	GO:0060074	15	1	18204	50	NFIA
4.043e-02	-3.21	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	50	NTRK2
4.043e-02	-3.21	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	50	MACF1
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	chondrocyte proliferation	biological process	GO:0035988	15	1	18204	50	FGFR3
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	50	SORBS1
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	exit from mitosis	biological process	GO:0010458	15	1	18204	50	NFIA
4.043e-02	-3.21	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	50	RORA
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	50	NTRK2
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	FMN2
4.076e-02	-3.20	TyrKc	smart domains	SM00219	80	2	9717	39	FGFR3,NTRK2
4.079e-02	-3.20	TJP1 (tight junction protein 1)	protein interactions	7082	297	3	19454	50	PARD3,DTNA,NEBL
4.079e-02	-3.20	SP7 (Sp7 transcription factor)	protein interactions	121340	297	3	19454	50	TRPS1,SOX5,NFIA
4.080e-02	-3.20	actin filament organization	biological process	GO:0007015	278	3	18204	50	FMN2,NEBL,SORBS1
4.082e-02	-3.20	metal ion binding	molecular function	GO:0046872	4239	17	18094	48	SLC1A2,MACF1,ATP1A2,DTNA,NRXN1,ADCY2,ZNRF3,GLIS3,RYR3,SLC1A3,ABLIM1,ZBTB20,SPARCL1,RORA,TRPS1,BMPR1B,ATP13A4
4.087e-02	-3.20	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	1	5310	17	RYR3
4.107e-02	-3.19	regulation of synapse assembly	biological process	GO:0051963	117	2	18204	50	NRXN1,NTRK2
4.117e-02	-3.19	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	48	SLC4A4,SLC1A3,SLC1A2
4.120e-02	-3.19	Neural Crest Differentiation	WikiPathways	WP2064	102	2	5310	17	FGFR3,SOX5
4.145e-02	-3.18	skin-acral-malignant_melanoma	COSMIC cancer mutations	skin-acral-malignant_melanoma	264	3	16828	49	CDH20,FMN2,PARD3
4.148e-02	-3.18	bicellular tight junction	cellular component	GO:0005923	126	2	19108	49	PARD3B,PARD3
4.163e-02	-3.18	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	48	ADCY2
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.168e-02	-3.18	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	5	18204	50	ZBTB20,FGFR3,NTRK2,TNIK,SLC4A4
4.168e-02	-3.18	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	5	18204	50	FGFR3,NTRK2,ZBTB20,SLC4A4,TNIK
4.193e-02	-3.17	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	50	NRG3,MACF1,SORBS1,FGFR3,NTRK2,ZNRF3,TNIK,BMPR1B,CTNND2,NFIA
4.193e-02	-3.17	response to stimulus	biological process	GO:0050896	7803	28	18204	50	SLC1A2,BMPR1B,RORA,ZNRF3,GPM6A,MACF1,PITPNC1,ZBTB20,PARD3,NRXN1,NFIA,DTNA,FMN2,CTNND2,TNIK,CST3,NRG3,ATP1A2,PREX2,RYR3,SOX5,SORBS1,SLC1A3,NTRK2,ADCY2,FGFR3,SPARCL1,CTNNA2
4.212e-02	-3.17	SLC-mediated transmembrane transport	REACTOME pathways	R-HSA-425407	287	3	10285	28	SLC4A4,SLC1A3,SLC1A2
4.223e-02	-3.16	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	3	16828	49	SOX5,RYR3,CDH20
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	NFIA,TRPS1
4.267e-02	-3.15	neuron projection terminus	cellular component	GO:0044306	128	2	19108	49	SLC1A2,NTRK2
4.271e-02	-3.15	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	1	10285	28	NRG3
4.271e-02	-3.15	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	28	NRG3
4.271e-02	-3.15	PKA activation	REACTOME pathways	R-HSA-163615	16	1	10285	28	ADCY2
4.282e-02	-3.15	ureter	COSMIC cancer mutations	ureter	15	1	16828	49	FGFR3
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.286e-02	-3.15	TEAD2 (TEA domain transcription factor 2)	protein interactions	8463	128	2	19454	50	ZBTB20,TRPS1
4.286e-02	-3.15	MYB (MYB proto-oncogene, transcription factor)	protein interactions	4602	128	2	19454	50	TRPS1,NFIA
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	MACF1,SOX5
4.297e-02	-3.15	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	6	19454	50	DTNA,FMN2,PARD3,SLC1A3,PREX2,MACF1
4.299e-02	-3.15	regulation of nervous system process	biological process	GO:0031644	120	2	18204	50	NRXN1,PARD3
4.302e-02	-3.15	acral	COSMIC cancer mutations	acral	268	3	16828	49	PARD3,FMN2,CDH20
4.307e-02	-3.14	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	50	ATP1A2
4.307e-02	-3.14	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	50	SLC1A3
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	50	ZNRF3
4.307e-02	-3.14	neuron cell-cell adhesion	biological process	GO:0007158	16	1	18204	50	NRXN1
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.329e-02	-3.14	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	49	TNIK,FGFR3,BMPR1B,NTRK2
4.330e-02	-3.14	RanBD	smart domains	SM00160	11	1	9717	39	RANBP3L
4.334e-02	-3.14	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	5	16828	49	SPARCL1,TNIK,FGFR3,BMPR1B,NTRK2
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	SOX5,ZBTB20
4.346e-02	-3.14	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	2	19454	50	ABLIM1,ZBTB20
4.357e-02	-3.13	LRRCT	smart domains	SM00082	83	2	9717	39	LRIG1,NTRK2
4.379e-02	-3.13	export from cell	biological process	GO:0140352	485	4	18204	50	NRXN1,NTRK2,ATP1A2,SLC4A4
4.381e-02	-3.13	cAMP signaling	KEGG pathways	hsa_M00695	16	1	7161	20	ADCY2
4.381e-02	-3.13	cAMP signaling	KEGG pathways	M00695	16	1	7161	20	ADCY2
4.388e-02	-3.13	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	49	BMPR1B,NTRK2,TNIK,FGFR3
4.388e-02	-3.13	Z disc	cellular component	GO:0030018	130	2	19108	49	NEBL,RYR3
4.395e-02	-3.12	ERK Pathway in Huntington's Disease	WikiPathways	WP3853	14	1	5310	17	NTRK2
4.407e-02	-3.12	DVL1 (dishevelled segment polarity protein 1)	protein interactions	1855	130	2	19454	50	ZNRF3,PARD3
4.410e-02	-3.12	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	9	16828	49	GPC5,PTPRZ1,PARD3,ZBTB20,NPAS3,SOX5,MACF1,NEBL,HIF3A
4.417e-02	-3.12	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	48	PTPRZ1
4.417e-02	-3.12	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	48	PTPRZ1
4.428e-02	-3.12	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	5	16828	49	SPARCL1,FGFR3,TNIK,BMPR1B,NTRK2
4.449e-02	-3.11	tight junction	cellular component	GO:0070160	131	2	19108	49	PARD3,PARD3B
4.467e-02	-3.11	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	44	FMN2
4.468e-02	-3.11	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	50	NFIA,RORA
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	NFIA,SOX5
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	SOX5,NFIA
4.470e-02	-3.11	EF_HAND_2	prosite domains	PS50222	215	3	12186	45	RYR3,MACF1,SPARCL1
4.477e-02	-3.11	Helix-loop-helix DNA-binding domain	gene3d domains	4.10.280.10	111	2	14470	44	HIF3A,NPAS3
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY2
4.493e-02	-3.10	PAC	interpro domains	IPR001610	17	1	18521	50	HIF3A
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	Cystatin_dom	interpro domains	IPR000010	17	1	18521	50	CST3
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	SLC1A2,ATP13A4,ZNRF3,GPM6A,PREX2,NEBL,RANBP3L,FBXL7,PTPRZ1,TRPS1,SLC4A4,NRG3,FGFR3,TNIK,NKAIN3,ABLIM1,NFIA,CST3,GLIS3,FMN2,GPC5,PARD3,RORA,RYR3,SOX5,BMPR1B,MSI2,LRIG1,HIF3A,NRXN1,LSAMP,NHSL1,CTNND2,MACF1,SFXN5,PARD3B,ZBTB20,SLC1A3,RFX4,SPARCL1,SORBS1,DTNA,NTM,ADCY2,PITPNC1,ATP1A2,NTRK2,CDH20,NPAS3
4.509e-02	-3.10	PIP3 activates AKT signaling	REACTOME pathways	R-HSA-1257604	125	2	10285	28	FGFR3,NRG3
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.532e-02	-3.09	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	REACTOME pathways	R-HSA-2173791	17	1	10285	28	PARD3
4.532e-02	-3.09	PKA activation in glucagon signalling	REACTOME pathways	R-HSA-164378	17	1	10285	28	ADCY2
4.532e-02	-3.09	PKA-mediated phosphorylation of CREB	REACTOME pathways	R-HSA-111931	17	1	10285	28	ADCY2
4.557e-02	-3.09	cytoskeletal protein binding	molecular function	GO:0008092	989	6	18094	48	FMN2,NEBL,MACF1,CTNNA2,ABLIM1,SORBS1
4.558e-02	-3.09	cellular process	biological process	GO:0009987	14996	46	18204	50	PTPRZ1,LSAMP,CST3,TNIK,FMN2,DTNA,RFX4,NFIA,PARD3,NRXN1,NEBL,PITPNC1,PARD3B,GPM6A,RORA,NTM,BMPR1B,SPARCL1,NTRK2,SLC4A4,ATP13A4,SORBS1,SOX5,PREX2,ATP1A2,CDH20,NRG3,MSI2,CTNND2,GLIS3,FBXL7,SFXN5,ABLIM1,ZBTB20,RANBP3L,MACF1,ZNRF3,NHSL1,SLC1A2,CTNNA2,GPC5,FGFR3,ADCY2,SLC1A3,HIF3A,RYR3
4.560e-02	-3.09	action potential	biological process	GO:0001508	124	2	18204	50	NTRK2,ATP1A2
4.560e-02	-3.09	positive regulation of lipid metabolic process	biological process	GO:0045834	124	2	18204	50	ZBTB20,SORBS1
4.561e-02	-3.09	flank	COSMIC cancer mutations	flank	16	1	16828	49	FGFR3
4.561e-02	-3.09	normal	COSMIC cancer mutations	normal	16	1	16828	49	FGFR3
4.561e-02	-3.09	urinary_tract-carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma	16	1	16828	49	FGFR3
4.561e-02	-3.09	renal_pelvis	COSMIC cancer mutations	renal_pelvis	16	1	16828	49	FGFR3
4.565e-02	-3.09	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	49	FGFR3,TNIK,NTRK2,BMPR1B
4.567e-02	-3.09	inorganic ion transmembrane transport	biological process	GO:0098660	715	5	18204	50	RYR3,SLC1A3,SLC4A4,ATP1A2,GPM6A
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	TNIK
4.570e-02	-3.09	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	50	NTRK2
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	cGMP metabolic process	biological process	GO:0046068	17	1	18204	50	RORA
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	50	SORBS1
4.570e-02	-3.09	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	50	CTNNA2
4.570e-02	-3.09	ureter development	biological process	GO:0072189	17	1	18204	50	NFIA
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	viral genome replication	biological process	GO:0019079	17	1	18204	50	NFIA
4.570e-02	-3.09	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	50	RORA
4.570e-02	-3.09	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	50	ATP1A2
4.581e-02	-3.08	Cystatin	pfam domains	PF00031	17	1	17795	49	CST3
4.581e-02	-3.08	ZZ	pfam domains	PF00569	17	1	17795	49	DTNA
4.581e-02	-3.08	Carb_anhydrase	pfam domains	PF00194	17	1	17795	49	PTPRZ1
4.615e-02	-3.08	cell cortex	cellular component	GO:0005938	313	3	19108	49	FMN2,PARD3,PARD3B
4.623e-02	-3.07	ion binding	molecular function	GO:0043167	6007	22	18094	48	ABLIM1,RORA,SPARCL1,NTRK2,BMPR1B,PITPNC1,FGFR3,PARD3,ADCY2,NRXN1,ZNRF3,ZBTB20,TRPS1,ATP13A4,TNIK,DTNA,ATP1A2,MACF1,SLC1A2,GLIS3,SLC1A3,RYR3
4.626e-02	-3.07	actomyosin structure organization	biological process	GO:0031032	125	2	18204	50	NEBL,SORBS1
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	GPM6A,NTM
4.671e-02	-3.06	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	48	NRG3
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.671e-02	-3.06	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	48	RYR3
4.704e-02	-3.06	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	45	NTRK2,FGFR3
4.706e-02	-3.06	GAB1 signalosome	REACTOME pathways	R-HSA-180292	128	2	10285	28	NRG3,FGFR3
4.706e-02	-3.06	PI3K/AKT activation	REACTOME pathways	R-HSA-198203	128	2	10285	28	NRG3,FGFR3
4.714e-02	-3.05	ZnF_GATA	smart domains	SM00401	12	1	9717	39	TRPS1
4.714e-02	-3.05	DWA	smart domains	SM00523	12	1	9717	39	NFIA
4.716e-02	-3.05	FOXP1 (forkhead box P1)	protein interactions	27086	135	2	19454	50	NFIA,SOX5
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	TRPS1,ABLIM1
4.716e-02	-3.05	SOX15 (SRY-box transcription factor 15)	protein interactions	6665	135	2	19454	50	TRPS1,NFIA
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	CDH20,PITPNC1,NTRK2,ATP1A2,NPAS3,DTNA,SORBS1,NTM,ADCY2,SPARCL1,RFX4,SFXN5,CTNND2,MACF1,ZBTB20,SLC1A3,PARD3B,LRIG1,HIF3A,NRXN1,MSI2,SOX5,BMPR1B,NHSL1,LSAMP,ABLIM1,NFIA,CST3,TNIK,FGFR3,NKAIN3,RYR3,FMN2,GPC5,GLIS3,RORA,PARD3,NEBL,PREX2,TRPS1,NRG3,SLC4A4,RANBP3L,PTPRZ1,FBXL7,ZNRF3,SLC1A2,ATP13A4,GPM6A
4.752e-02	-3.05	Leu-rich_rpt_4	interpro domains	IPR025875	18	1	18521	50	LRIG1
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY2
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY2
4.752e-02	-3.05	Leu-rich_rpt_Cys-con_subtyp	interpro domains	IPR006553	18	1	18521	50	FBXL7
4.760e-02	-3.05	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	50	PARD3,CDH20
4.760e-02	-3.05	response to amino acid	biological process	GO:0043200	127	2	18204	50	SLC1A2,NTRK2
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	TNIK,NTRK2,CTNND2
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.764e-02	-3.04	astrocyte projection	cellular component	GO:0097449	19	1	19108	49	SLC1A2
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.772e-02	-3.04	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	49	CTNND2,FMN2
4.774e-02	-3.04	NLGN1 (neuroligin 1)	protein interactions	22871	19	1	19454	50	NRXN1
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	50	NRXN1
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.782e-02	-3.04	regulation of multicellular organismal development	biological process	GO:2000026	1484	8	18204	50	TRPS1,MACF1,NTRK2,PTPRZ1,PARD3,NRXN1,SOX5,BMPR1B
4.792e-02	-3.04	PI-3K cascade:FGFR3	REACTOME pathways	R-HSA-5654710	18	1	10285	28	FGFR3
4.792e-02	-3.04	SHC-mediated cascade:FGFR3	REACTOME pathways	R-HSA-5654704	18	1	10285	28	FGFR3
4.793e-02	-3.04	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	3	16828	49	PREX2,TNIK,ATP1A2
4.804e-02	-3.04	muscle system process	biological process	GO:0003012	297	3	18204	50	RYR3,ATP1A2,DTNA
4.822e-02	-3.03	cell population proliferation	biological process	GO:0008283	726	5	18204	50	SOX5,RORA,ZNRF3,NFIA,FGFR3
4.827e-02	-3.03	myelination	biological process	GO:0042552	128	2	18204	50	NTRK2,PARD3
4.827e-02	-3.03	glial cell development	biological process	GO:0021782	128	2	18204	50	NTRK2,PARD3
4.831e-02	-3.03	regulation of signaling	biological process	GO:0023051	3534	15	18204	50	FGFR3,NTRK2,GPC5,NRG3,NRXN1,CTNND2,SLC1A3,TNIK,SORBS1,MACF1,ATP1A2,PREX2,BMPR1B,RORA,ZNRF3
4.832e-02	-3.03	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	50	NTRK2
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.832e-02	-3.03	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	50	RORA
4.832e-02	-3.03	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	50	CST3
4.832e-02	-3.03	receptor catabolic process	biological process	GO:0032801	18	1	18204	50	ZNRF3
4.832e-02	-3.03	positive regulation of myelination	biological process	GO:0031643	18	1	18204	50	PARD3
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	50	NEBL
4.837e-02	-3.03	SH3	prosite domains	PS50002	222	3	12186	45	NEBL,MACF1,SORBS1
4.838e-02	-3.03	TYRKINASE	prints domains	PR00109	98	2	5227	19	FGFR3,NTRK2
4.839e-02	-3.03	skin-non_chronically_sun_exposed_site-malignant_melanoma	COSMIC cancer mutations	skin-non_chronically_sun_exposed_site-malignant_melanoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	breast-carcinoma-neuroendocrine_carcinoma	COSMIC cancer mutations	breast-carcinoma-neuroendocrine_carcinoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-other-verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	skin-other-verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	non_chronically_sun_exposed_site	COSMIC cancer mutations	non_chronically_sun_exposed_site	17	1	16828	49	FGFR3
4.839e-02	-3.03	verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.842e-02	-3.03	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	2	19454	50	NFIA,SOX5
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY2
4.844e-02	-3.03	LRR_4	pfam domains	PF12799	18	1	17795	49	LRIG1
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.905e-02	-3.01	regulation of cell communication	biological process	GO:0010646	3541	15	18204	50	NRXN1,SLC1A3,CTNND2,TNIK,NTRK2,FGFR3,GPC5,NRG3,ATP1A2,PREX2,BMPR1B,RORA,ZNRF3,SORBS1,MACF1
4.906e-02	-3.01	Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME pathways	R-HSA-2730905	131	2	10285	28	FGFR3,NRG3
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	SORBS1,MACF1,DTNA
4.951e-02	-3.01	cellular response to organonitrogen compound	biological process	GO:0071417	505	4	18204	50	SLC1A3,RYR3,SORBS1,SLC1A2
4.962e-02	-3.00	ensheathment of neurons	biological process	GO:0007272	130	2	18204	50	NTRK2,PARD3
4.962e-02	-3.00	axon ensheathment	biological process	GO:0008366	130	2	18204	50	PARD3,NTRK2
4.969e-02	-3.00	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	4	12186	45	NTRK2,TNIK,BMPR1B,FGFR3