Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
6.000e-10	-21.23	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	46	16828	49	AHCYL2,FBXL7,LIFR,SPARCL1,RYR3,BMPR1B,DTNA,LSAMP,GLIS3,HIF3A,ZBTB20,SLC4A4,PITPNC1,SFXN5,FGFR3,PARD3B,NEBL,MSI2,PTPRZ1,FMN2,GPC5,MAML2,CTNND2,SLC1A3,NTM,GLUD1,ATP13A4,MACF1,NHSL1,SOX5,SLC1A2,NKAIN3,NFIA,NRXN1,NPAS3,PCDH9,PREX2,ITPR2,ABLIM1,RORA,CPE,NTRK2,GPM6A,TRPS1,CDH20,TNIK
1.443e-09	-20.36	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	31	16828	49	HIF3A,GLIS3,LSAMP,PREX2,PCDH9,ZBTB20,ITPR2,SLC4A4,NEBL,CPE,RORA,NTRK2,PTPRZ1,GPM6A,CTNND2,SLC1A3,MAML2,FMN2,GPC5,TNIK,NTM,FBXL7,ATP13A4,LIFR,SLC1A2,BMPR1B,SOX5,RYR3,NKAIN3,NFIA,NRXN1
1.443e-09	-20.36	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	31	16828	49	SLC4A4,ITPR2,ZBTB20,PREX2,PCDH9,LSAMP,GLIS3,HIF3A,TNIK,FMN2,MAML2,GPC5,SLC1A3,CTNND2,GPM6A,PTPRZ1,NTRK2,RORA,CPE,NEBL,LIFR,FBXL7,ATP13A4,NTM,NRXN1,NFIA,NKAIN3,SOX5,RYR3,SLC1A2,BMPR1B
9.497e-09	-18.47	brainstem	COSMIC cancer mutations	brainstem	3102	27	16828	49	LIFR,FBXL7,ATP13A4,AHCYL2,NKAIN3,SOX5,RYR3,SLC1A2,FGFR3,SFXN5,ITPR2,PCDH9,PREX2,ZBTB20,NPAS3,LSAMP,SLC1A3,CTNND2,GPC5,FMN2,MAML2,TNIK,CDH20,GPM6A,PTPRZ1,RORA,CPE
9.808e-09	-18.44	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	16	19454	50	PTPRZ1,MACF1,TRPS1,CPE,SLC1A3,GPM6A,SLC4A4,AHCYL2,LSAMP,ABLIM1,ATP1A2,GLUD1,NHSL1,MSI2,SPARCL1,MAML2
1.790e-08	-17.84	lymph_node	COSMIC cancer mutations	lymph_node	1703	20	16828	49	GPM6A,TRPS1,SLC1A3,CTNND2,MAML2,TNIK,GPC5,SOX5,RYR3,NEBL,DTNA,NTRK2,SFXN5,LIFR,ITPR2,PARD3B,FGFR3,LSAMP,ATP13A4,PCDH9
2.195e-08	-17.63	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	24	16828	49	NKAIN3,RYR3,SOX5,LIFR,ATP13A4,FBXL7,AHCYL2,FMN2,MAML2,TNIK,GPC5,CTNND2,SLC1A3,PTPRZ1,GPM6A,CDH20,RORA,CPE,ITPR2,SFXN5,ZBTB20,PCDH9,PREX2,LSAMP
2.342e-08	-17.57	cerebellum	COSMIC cancer mutations	cerebellum	769	14	16828	49	PTPRZ1,MAML2,GPC5,CTNND2,NRXN1,CPE,NEBL,RYR3,NTRK2,ITPR2,ABLIM1,PARD3B,NPAS3,PCDH9
2.351e-08	-17.57	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	22	16828	49	NPAS3,FBXL7,PCDH9,PREX2,ATP13A4,AHCYL2,LSAMP,NHSL1,ITPR2,NKAIN3,NTRK2,CPE,SLC1A2,BMPR1B,SOX5,RYR3,GPC5,MAML2,FMN2,SLC1A3,CTNND2,GPM6A
2.351e-08	-17.57	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	22	16828	49	AHCYL2,FBXL7,ATP13A4,NHSL1,SLC1A2,BMPR1B,SOX5,RYR3,NKAIN3,LSAMP,NPAS3,PREX2,PCDH9,ITPR2,CPE,NTRK2,GPM6A,GPC5,FMN2,MAML2,CTNND2,SLC1A3
2.815e-08	-17.39	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	40	16828	49	MACF1,LIFR,NHSL1,GLUD1,NTM,AHCYL2,FBXL7,ATP13A4,NRXN1,RYR3,SOX5,SLC1A2,NKAIN3,NFIA,SFXN5,SLC4A4,PITPNC1,ITPR2,PARD3B,ABLIM1,FGFR3,GLIS3,LSAMP,PREX2,PCDH9,ZBTB20,NPAS3,PTPRZ1,GPM6A,TRPS1,CTNND2,SLC1A3,GPC5,MAML2,TNIK,FMN2,NEBL,RORA,CPE,NTRK2
2.907e-08	-17.35	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	13	16828	49	ABLIM1,PARD3B,ITPR2,NPAS3,PCDH9,MAML2,CTNND2,NRXN1,PTPRZ1,NTRK2,CPE,NEBL,RYR3
2.960e-08	-17.34	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	13	16828	49	NTRK2,NPAS3,PCDH9,CPE,NEBL,RYR3,MAML2,ABLIM1,PARD3B,CTNND2,NRXN1,ITPR2,PTPRZ1
5.958e-08	-16.64	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	30	16828	49	FBXL7,ATP13A4,AHCYL2,SPARCL1,MACF1,LIFR,NKAIN3,DTNA,SOX5,RYR3,SLC1A2,PREX2,PCDH9,LSAMP,FGFR3,ATP1A2,ITPR2,NTRK2,RORA,CPE,NEBL,FMN2,GPC5,TNIK,MAML2,SLC1A3,CTNND2,GPM6A,TRPS1,CDH20
1.045e-07	-16.07	nodular	COSMIC cancer mutations	nodular	1515	18	16828	49	FMN2,CTNND2,PTPRZ1,CDH20,NTRK2,CPE,NEBL,ABLIM1,SPARCL1,FGFR3,ATP1A2,MACF1,SLC4A4,NPAS3,PREX2,ATP13A4,GLIS3,HIF3A
2.237e-07	-15.31	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	24	16828	49	SOX5,RYR3,SLC1A2,NKAIN3,ATP13A4,FBXL7,LIFR,CPE,NEBL,NTRK2,GPM6A,TRPS1,MAML2,FMN2,GPC5,SLC1A3,CTNND2,LSAMP,HIF3A,PREX2,PCDH9,ITPR2,SFXN5,PARD3B
2.894e-07	-15.06	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	11	16828	49	FMN2,GPC5,CTNND2,GPM6A,SFXN5,NKAIN3,PCDH9,LSAMP,AHCYL2,SOX5,RYR3
4.615e-07	-14.59	nervous system development	biological process	GO:0007399	2185	20	18204	50	CTNND2,PTPRZ1,BMPR1B,NTRK2,SOX5,NFIA,CTNNA2,TNIK,SLC1A2,LSAMP,PREX2,NTM,GLUD1,ATP1A2,NRXN1,MSI2,GPM6A,PCDH9,SLC1A3,RORA
5.011e-07	-14.51	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	23	16828	49	LIFR,ITPR2,SFXN5,PARD3B,LSAMP,HIF3A,PCDH9,PREX2,FBXL7,GPM6A,TRPS1,GPC5,MAML2,FMN2,SLC1A3,CTNND2,CPE,SOX5,RYR3,SLC1A2,NEBL,NKAIN3,NTRK2
6.436e-07	-14.26	plasma membrane	cellular component	GO:0005886	5538	31	19108	49	FGFR3,PREX2,NTRK2,PTPRZ1,CST3,PCDH9,CDH20,ATP1A2,ATP13A4,ITPR2,TNIK,DTNA,BMPR1B,NTM,FMN2,NRXN1,PARD3B,LIFR,CTNNA2,MACF1,NKAIN3,CPE,HIF3A,CTNND2,GPM6A,GPC5,SLC4A4,SLC1A2,RYR3,LSAMP,SLC1A3
8.806e-07	-13.94	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	19	16828	49	SLC4A4,MACF1,ITPR2,PARD3B,FGFR3,AHCYL2,PCDH9,ZBTB20,NPAS3,GPM6A,NRXN1,TNIK,MAML2,FMN2,SOX5,RYR3,BMPR1B,NEBL,RORA
8.947e-07	-13.93	larynx	COSMIC cancer mutations	larynx	1948	19	16828	49	FMN2,TNIK,MAML2,NRXN1,GPM6A,RORA,RYR3,SOX5,BMPR1B,NEBL,FGFR3,PARD3B,SLC4A4,MACF1,ITPR2,ZBTB20,NPAS3,PCDH9,AHCYL2
1.129e-06	-13.69	system development	biological process	GO:0048731	3533	25	18204	50	CTNND2,NEBL,PTPRZ1,HIF3A,TRPS1,CTNNA2,NFIA,GLUD1,NTM,RORA,MSI2,NTRK2,SOX5,BMPR1B,FGFR3,TNIK,SLC1A2,ATP1A2,CPE,LSAMP,PREX2,SLC1A3,GPM6A,PCDH9,NRXN1
1.153e-06	-13.67	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	26	16828	49	FGFR3,ATP1A2,ITPR2,PCDH9,PREX2,LSAMP,GPC5,TNIK,MAML2,FMN2,CTNND2,GPM6A,CDH20,RORA,CPE,NEBL,SPARCL1,MACF1,LIFR,FBXL7,ATP13A4,AHCYL2,NKAIN3,SOX5,RYR3,SLC1A2
1.167e-06	-13.66	cell periphery	cellular component	GO:0071944	6020	32	19108	49	PARD3B,LIFR,NRXN1,BMPR1B,FMN2,NTM,ATP13A4,DTNA,TNIK,ITPR2,PCDH9,ATP1A2,CDH20,CST3,PTPRZ1,FGFR3,PREX2,NTRK2,SPARCL1,RYR3,LSAMP,SLC1A3,GPC5,SLC1A2,SLC4A4,GPM6A,HIF3A,CTNND2,MACF1,CPE,NKAIN3,CTNNA2
1.343e-06	-13.52	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	20	16828	49	NTRK2,NKAIN3,RYR3,SOX5,SLC1A2,NEBL,CTNND2,SLC1A3,FMN2,GPC5,MAML2,CDH20,GPM6A,PTPRZ1,FBXL7,PCDH9,PREX2,LSAMP,FGFR3,ITPR2
1.377e-06	-13.50	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	12	16828	49	SLC1A2,SOX5,RYR3,NKAIN3,NTRK2,MAML2,GPC5,LSAMP,PREX2,FBXL7,PCDH9,ATP1A2
1.771e-06	-13.24	generation of neurons	biological process	GO:0048699	1158	14	18204	50	RORA,SLC1A3,GPM6A,NRXN1,NTM,PREX2,TNIK,CTNNA2,NFIA,NTRK2,SOX5,BMPR1B,CTNND2,PTPRZ1
1.990e-06	-13.13	cell morphogenesis	biological process	GO:0000902	687	11	18204	50	BMPR1B,CTNND2,PTPRZ1,TNIK,NFIA,CTNNA2,CDH20,PREX2,SLC1A3,NRXN1,GPM6A
2.256e-06	-13.00	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	15	16828	49	NEBL,CPE,NTRK2,CDH20,PTPRZ1,CTNND2,HIF3A,GLIS3,ATP13A4,PREX2,NPAS3,MACF1,ATP1A2,ABLIM1,SPARCL1
2.521e-06	-12.89	multicellular organism development	biological process	GO:0007275	3957	26	18204	50	SLC1A3,GPM6A,PCDH9,NRXN1,ATP1A2,CPE,CDH20,LSAMP,PREX2,SLC1A2,TNIK,NTRK2,SOX5,BMPR1B,FGFR3,RORA,MSI2,GLUD1,NTM,HIF3A,TRPS1,CTNNA2,NFIA,CTNND2,PTPRZ1,NEBL
2.948e-06	-12.73	anatomical structure morphogenesis	biological process	GO:0009653	2225	19	18204	50	HIF3A,ABLIM1,TNIK,CTNNA2,NFIA,SOX5,NTRK2,BMPR1B,FGFR3,NEBL,PTPRZ1,CTNND2,RORA,SLC1A3,GPM6A,NRXN1,CPE,PREX2,CDH20
3.130e-06	-12.67	humerus	COSMIC cancer mutations	humerus	546	10	16828	49	NKAIN3,AHCYL2,NEBL,HIF3A,SOX5,FMN2,GPC5,PARD3B,GPM6A,SFXN5
3.494e-06	-12.56	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	FBXL7,PREX2,PCDH9,LSAMP,ITPR2,NTRK2,NKAIN3,SOX5,RYR3,NEBL,RORA,SLC1A3,CTNND2,MAML2,GPC5,FMN2
3.494e-06	-12.56	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	16	16828	49	LSAMP,PREX2,FBXL7,PCDH9,ITPR2,NEBL,RYR3,SOX5,RORA,NKAIN3,NTRK2,CTNND2,SLC1A3,FMN2,GPC5,MAML2
3.540e-06	-12.55	trunk	COSMIC cancer mutations	trunk	3554	25	16828	49	SOX5,RYR3,NRXN1,ATP13A4,MACF1,LIFR,SPARCL1,CPE,NEBL,NTRK2,PTPRZ1,TRPS1,CDH20,MAML2,SLC1A3,CTNND2,LSAMP,GLIS3,HIF3A,NPAS3,PCDH9,PREX2,ABLIM1,FGFR3,ATP1A2
4.001e-06	-12.43	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	14	16828	49	LSAMP,NPAS3,FBXL7,PREX2,FGFR3,ATP1A2,RYR3,SOX5,SLC1A2,BMPR1B,NFIA,NKAIN3,NTRK2,TNIK
4.001e-06	-12.43	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	14	16828	49	NFIA,NKAIN3,NTRK2,SOX5,RYR3,BMPR1B,SLC1A2,TNIK,PREX2,FBXL7,NPAS3,LSAMP,ATP1A2,FGFR3
4.805e-06	-12.25	neuron differentiation	biological process	GO:0030182	1081	13	18204	50	NTM,PREX2,GPM6A,NRXN1,RORA,SLC1A3,CTNND2,PTPRZ1,NTRK2,BMPR1B,CTNNA2,NFIA,TNIK
5.357e-06	-12.14	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	19	16828	49	LSAMP,FBXL7,PREX2,PCDH9,ITPR2,SLC1A2,NEBL,SOX5,RYR3,NTRK2,NKAIN3,CDH20,GPM6A,PTPRZ1,SLC1A3,CTNND2,FMN2,GPC5,MAML2
5.357e-06	-12.14	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	19	16828	49	LSAMP,PREX2,PCDH9,FBXL7,ITPR2,NEBL,SLC1A2,SOX5,RYR3,NTRK2,NKAIN3,CDH20,GPM6A,PTPRZ1,CTNND2,SLC1A3,GPC5,MAML2,FMN2
7.388e-06	-11.82	pharynx	COSMIC cancer mutations	pharynx	2696	21	16828	49	CTNND2,FMN2,GPC5,PTPRZ1,DTNA,NTRK2,NFIA,RYR3,SLC1A2,NHSL1,PARD3B,ATP1A2,FGFR3,SFXN5,SLC4A4,MACF1,PITPNC1,PCDH9,PREX2,ATP13A4,NPAS3
7.407e-06	-11.81	bone	COSMIC cancer mutations	bone	8157	39	16828	49	PTGDS,ATP13A4,AHCYL2,SPARCL1,LIFR,MACF1,NKAIN3,DTNA,SOX5,RYR3,NRXN1,ZBTB20,NPAS3,CST3,PREX2,PCDH9,GLIS3,LSAMP,HIF3A,FGFR3,ABLIM1,ATP1A2,PARD3B,ITPR2,SLC4A4,SFXN5,NTRK2,CPE,RORA,NEBL,MAML2,FMN2,TNIK,GPC5,SLC1A3,CTNND2,TRPS1,PTPRZ1,GPM6A
8.073e-06	-11.73	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	9	16828	49	PCDH9,ATP13A4,LSAMP,RYR3,MAML2,GPC5,CTNND2,GPM6A,SFXN5
9.205e-06	-11.60	neurogenesis	biological process	GO:0022008	1334	14	18204	50	TNIK,NFIA,CTNNA2,BMPR1B,SOX5,NTRK2,PTPRZ1,CTNND2,SLC1A3,RORA,NRXN1,GPM6A,PREX2,NTM
1.167e-05	-11.36	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	34	16828	49	HIF3A,GLIS3,PCDH9,PREX2,NPAS3,ZBTB20,SFXN5,SLC4A4,PITPNC1,ITPR2,PARD3B,ATP1A2,ABLIM1,FGFR3,NEBL,CPE,PTPRZ1,GPM6A,TRPS1,CTNND2,GPC5,FMN2,MAML2,TNIK,GLUD1,ATP13A4,FBXL7,MACF1,LIFR,SPARCL1,SOX5,RYR3,BMPR1B,NRXN1
1.311e-05	-11.24	anatomical structure development	biological process	GO:0048856	5207	29	18204	50	NTM,GLUD1,MSI2,RORA,CTNND2,SPARCL1,NEBL,PTPRZ1,CTNNA2,NFIA,HIF3A,TRPS1,ABLIM1,FMN2,CDH20,LSAMP,PREX2,ATP1A2,CPE,GPM6A,PCDH9,NRXN1,SLC1A3,FGFR3,NTRK2,SOX5,BMPR1B,SLC1A2,TNIK
1.668e-05	-11.00	neuron development	biological process	GO:0048666	859	11	18204	50	TNIK,CTNNA2,NTRK2,BMPR1B,PTPRZ1,CTNND2,SLC1A3,GPM6A,NRXN1,NTM,PREX2
1.766e-05	-10.94	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	3	19454	50	NRXN1,CTNND2,CST3
1.836e-05	-10.91	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	7	19454	50	NEBL,CTNNA2,MACF1,NHSL1,TNIK,DTNA,ABLIM1
1.886e-05	-10.88	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	35	16828	49	NTM,FBXL7,ATP13A4,MACF1,NHSL1,RYR3,SOX5,SLC1A2,DTNA,NRXN1,HIF3A,LSAMP,PCDH9,PREX2,CST3,ZBTB20,SFXN5,SLC4A4,PITPNC1,ITPR2,PARD3B,ATP1A2,ABLIM1,FGFR3,NEBL,RORA,CDH20,GPM6A,PTPRZ1,TRPS1,CTNND2,GPC5,FMN2,MAML2,TNIK
2.057e-05	-10.79	cell junction	cellular component	GO:0030054	2224	17	19108	49	CDH20,ATP1A2,PCDH9,PTPRZ1,CTNND2,NTRK2,FGFR3,CTNNA2,SPARCL1,NFIA,PARD3B,SLC1A3,NRXN1,SLC1A2,GPM6A,TNIK,DTNA
2.256e-05	-10.70	MAPT (microtubule associated protein tau)	protein interactions	4137	948	11	19454	50	ATP1A2,SLC1A2,TNIK,CTNNA2,CTNND2,ABLIM1,LSAMP,GPM6A,NTM,NEBL,SLC1A3
2.465e-05	-10.61	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	7	16828	49	AHCYL2,SOX5,NKAIN3,GPM6A,SFXN5,GPC5,FMN2
2.773e-05	-10.49	developmental process	biological process	GO:0032502	5716	30	18204	50	FMN2,PREX2,CDH20,LSAMP,CPE,ATP1A2,PCDH9,GPM6A,NRXN1,SLC1A3,FGFR3,SOX5,NTRK2,BMPR1B,NHSL1,SLC1A2,TNIK,NTM,GLUD1,MSI2,RORA,SPARCL1,NEBL,PTPRZ1,CTNND2,CTNNA2,NFIA,HIF3A,TRPS1,ABLIM1
2.973e-05	-10.42	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	47	16828	49	NTM,AHCYL2,GLUD1,ATP13A4,FBXL7,MACF1,LIFR,SPARCL1,NHSL1,RYR3,SOX5,BMPR1B,SLC1A2,NFIA,NKAIN3,DTNA,NRXN1,GLIS3,LSAMP,HIF3A,NPAS3,ZBTB20,PREX2,PCDH9,SLC4A4,PITPNC1,ITPR2,SFXN5,ABLIM1,FGFR3,PARD3B,ATP1A2,RORA,CPE,NEBL,NTRK2,MSI2,GPM6A,PTPRZ1,TRPS1,CDH20,MAML2,GPC5,TNIK,FMN2,CTNND2,SLC1A3
3.062e-05	-10.39	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	26	16828	49	NTM,PTGDS,FBXL7,ATP13A4,MACF1,LIFR,NHSL1,RYR3,SOX5,NFIA,HIF3A,ZBTB20,PREX2,PCDH9,SLC4A4,ITPR2,FGFR3,PARD3B,NTRK2,GPM6A,PTPRZ1,TRPS1,CDH20,FMN2,TNIK,CTNND2
3.254e-05	-10.33	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	25	16828	49	RYR3,SLC1A2,NFIA,FBXL7,MACF1,NHSL1,NEBL,NTRK2,PTPRZ1,GPM6A,TRPS1,CTNND2,TNIK,FMN2,MAML2,HIF3A,GLIS3,PREX2,PCDH9,NPAS3,SLC4A4,PITPNC1,PARD3B,ATP1A2,FGFR3
4.501e-05	-10.01	multicellular organismal process	biological process	GO:0032501	6177	31	18204	50	NFIA,CTNNA2,ABLIM1,TRPS1,HIF3A,DTNA,CTNND2,NEBL,PTPRZ1,MSI2,PTGDS,RORA,SLC4A4,NTM,GLUD1,TNIK,SLC1A2,FGFR3,BMPR1B,NTRK2,SOX5,NRXN1,GPM6A,PCDH9,RYR3,SLC1A3,LSAMP,CDH20,PREX2,ATP1A2,CPE
4.590e-05	-9.99	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	29	SLC1A2,SLC1A3
4.590e-05	-9.99	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	29	SLC1A3,SLC1A2
4.606e-05	-9.99	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	13	16828	49	ATP13A4,NTRK2,RYR3,NEBL,NTM,CTNND2,ABLIM1,FMN2,TNIK,FGFR3,GPM6A,MACF1,TRPS1
4.606e-05	-9.99	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	13	16828	49	MACF1,FGFR3,ABLIM1,NTM,ATP13A4,TRPS1,GPM6A,TNIK,FMN2,CTNND2,NEBL,RYR3,NTRK2
4.882e-05	-9.93	neuron projection morphogenesis	biological process	GO:0048812	486	8	18204	50	TNIK,NRXN1,GPM6A,CTNNA2,BMPR1B,PTPRZ1,PREX2,CTNND2
4.916e-05	-9.92	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	3	7161	23	ATP1A2,SLC4A4,GLUD1
4.916e-05	-9.92	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	3	7161	23	SLC4A4,ATP1A2,GLUD1
5.246e-05	-9.86	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	8	18204	50	NRXN1,GPM6A,CTNNA2,TNIK,CTNND2,PREX2,PTPRZ1,BMPR1B
5.396e-05	-9.83	scalp	COSMIC cancer mutations	scalp	2110	17	16828	49	MACF1,SLC4A4,FGFR3,ATP1A2,NTM,LSAMP,ATP13A4,PREX2,PTPRZ1,TRPS1,GPC5,FMN2,NRXN1,RORA,SOX5,NEBL,NFIA
5.634e-05	-9.78	cell projection morphogenesis	biological process	GO:0048858	496	8	18204	50	PREX2,PTPRZ1,CTNND2,BMPR1B,GPM6A,CTNNA2,NRXN1,TNIK
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A2,SLC1A3
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A3,SLC1A2
7.355e-05	-9.52	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	50	SLC1A3,SLC1A2
7.355e-05	-9.52	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	50	SLC1A2,SLC1A3
7.513e-05	-9.50	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	50	SLC1A3,SLC1A2,ATP1A2
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	LSAMP,GPM6A,NTM
9.059e-05	-9.31	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	50	SLC4A4,ATP1A2,SLC1A3,SLC1A2
9.059e-05	-9.31	vascular transport	biological process	GO:0010232	86	4	18204	50	SLC1A3,SLC1A2,ATP1A2,SLC4A4
9.314e-05	-9.28	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	24	16828	49	FBXL7,MACF1,NFIA,SLC1A2,RYR3,NPAS3,PCDH9,PREX2,GLIS3,HIF3A,FGFR3,ATP1A2,PARD3B,PITPNC1,SLC4A4,NTRK2,NEBL,MAML2,TNIK,FMN2,CTNND2,TRPS1,GPM6A,PTPRZ1
9.354e-05	-9.28	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	24	16828	49	MACF1,FBXL7,NFIA,RYR3,SLC1A2,FGFR3,PARD3B,ATP1A2,SLC4A4,PITPNC1,NPAS3,PCDH9,PREX2,GLIS3,HIF3A,FMN2,TNIK,MAML2,CTNND2,PTPRZ1,GPM6A,TRPS1,NTRK2,NEBL
1.004e-04	-9.21	response to auditory stimulus	biological process	GO:0010996	33	3	18204	50	NRXN1,SLC1A3,ATP1A2
1.064e-04	-9.15	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	Ins145_P3_rcpt	interpro domains	IPR014821	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	RIH_dom	interpro domains	IPR000699	6	2	18521	50	ITPR2,RYR3
1.064e-04	-9.15	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	RIH_assoc-dom	interpro domains	IPR013662	6	2	18521	50	ITPR2,RYR3
1.101e-04	-9.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	50	SLC1A2,SLC1A3
1.101e-04	-9.11	D-amino acid transport	biological process	GO:0042940	6	2	18204	50	SLC1A2,SLC1A3
1.152e-04	-9.07	Ins145_P3_rec	pfam domains	PF08709	6	2	17795	50	RYR3,ITPR2
1.152e-04	-9.07	RYDR_ITPR	pfam domains	PF01365	6	2	17795	50	ITPR2,RYR3
1.152e-04	-9.07	RIH_assoc	pfam domains	PF08454	6	2	17795	50	ITPR2,RYR3
1.219e-04	-9.01	tibia	COSMIC cancer mutations	tibia	836	10	16828	49	MACF1,GPM6A,ABLIM1,TNIK,FGFR3,CTNND2,CPE,LSAMP,NKAIN3,PREX2
1.329e-04	-8.93	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	22	16828	49	SLC1A3,CTNND2,TNIK,FMN2,GPC5,PTPRZ1,MSI2,NTRK2,CPE,PARD3B,PITPNC1,SLC4A4,PCDH9,PREX2,NPAS3,LSAMP,DTNA,BMPR1B,RYR3,LIFR,MACF1,FBXL7
1.329e-04	-8.93	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	22	16828	49	NTRK2,MSI2,CPE,TNIK,GPC5,FMN2,CTNND2,SLC1A3,PTPRZ1,NPAS3,PCDH9,PREX2,LSAMP,PARD3B,PITPNC1,SLC4A4,DTNA,BMPR1B,RYR3,FBXL7,LIFR,MACF1
1.342e-04	-8.92	mouth	COSMIC cancer mutations	mouth	9004	39	16828	49	NTRK2,RORA,NEBL,FMN2,GPC5,MAML2,TNIK,SLC1A3,CTNND2,PTPRZ1,GPM6A,TRPS1,CDH20,NPAS3,ZBTB20,CST3,PREX2,PCDH9,LSAMP,HIF3A,ABLIM1,FGFR3,PARD3B,ATP1A2,SLC4A4,PITPNC1,ITPR2,SFXN5,DTNA,SOX5,RYR3,SLC1A2,NRXN1,ATP13A4,FBXL7,NTM,NHSL1,MACF1,LIFR
1.345e-04	-8.91	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	2	14470	44	ITPR2,RYR3
1.374e-04	-8.89	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	6	19454	50	AHCYL2,ABLIM1,DTNA,TNIK,FMN2,MACF1
1.378e-04	-8.89	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	9	18094	48	RYR3,GPM6A,SLC4A4,ITPR2,SLC1A3,ATP1A2,SLC1A2,ATP13A4,SFXN5
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A3,SLC1A2
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A3,SLC1A2
1.534e-04	-8.78	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	7	18094	48	SLC1A3,RYR3,ATP1A2,ITPR2,SLC4A4,SLC1A2,GPM6A
1.583e-04	-8.75	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	13	16828	49	PITPNC1,SLC4A4,SFXN5,FGFR3,ATP1A2,NHSL1,ATP13A4,PREX2,FMN2,CTNND2,SLC1A2,NFIA,NTRK2
1.583e-04	-8.75	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	13	16828	49	FMN2,CTNND2,SLC1A2,NTRK2,NFIA,SLC4A4,PITPNC1,SFXN5,FGFR3,NHSL1,ATP1A2,ATP13A4,PREX2
1.610e-04	-8.73	SDF	pfam domains	PF00375	7	2	17795	50	SLC1A2,SLC1A3
1.662e-04	-8.70	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	50	SLC1A3,RYR3,SLC1A2
1.721e-04	-8.67	Salivary secretion	KEGG pathways	ko04970	90	4	7161	23	CST3,RYR3,ITPR2,ATP1A2
1.721e-04	-8.67	Salivary secretion	KEGG pathways	hsa04970	90	4	7161	23	CST3,RYR3,ITPR2,ATP1A2
1.810e-04	-8.62	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	41	16828	49	NTRK2,MSI2,RORA,CPE,NEBL,GPC5,TNIK,FMN2,MAML2,CTNND2,GPM6A,PTPRZ1,TRPS1,CDH20,CST3,NPAS3,PREX2,PCDH9,HIF3A,ABLIM1,FGFR3,PARD3B,ATP1A2,SLC4A4,PITPNC1,ITPR2,NFIA,NKAIN3,DTNA,RYR3,SOX5,BMPR1B,NRXN1,FBXL7,ATP13A4,NTM,AHCYL2,GLUD1,SPARCL1,MACF1,LIFR
1.838e-04	-8.60	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	41	16828	49	PTPRZ1,GPM6A,TRPS1,CDH20,FMN2,MAML2,GPC5,TNIK,CTNND2,RORA,CPE,NEBL,NTRK2,MSI2,SLC4A4,PITPNC1,ITPR2,ABLIM1,FGFR3,PARD3B,ATP1A2,HIF3A,NPAS3,CST3,PCDH9,PREX2,NRXN1,RYR3,SOX5,BMPR1B,NKAIN3,NFIA,DTNA,MACF1,LIFR,SPARCL1,NTM,AHCYL2,GLUD1,FBXL7,ATP13A4
1.841e-04	-8.60	beta-catenin binding	molecular function	GO:0008013	107	4	18094	48	RORA,CTNNA2,CDH20,CTNND2
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	NKAIN3,CTNND2,GPM6A,LSAMP
1.879e-04	-8.58	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	44	SLC1A2,SLC1A3
1.949e-04	-8.54	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	7	18204	50	PTPRZ1,PREX2,CTNND2,BMPR1B,NRXN1,CTNNA2,SLC1A3
2.071e-04	-8.48	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	42	16828	49	BMPR1B,SLC1A2,RYR3,SOX5,DTNA,NKAIN3,NFIA,NRXN1,AHCYL2,NTM,FBXL7,ATP13A4,LIFR,MACF1,NEBL,CPE,RORA,NTRK2,CDH20,TRPS1,PTPRZ1,GPM6A,CTNND2,SLC1A3,TNIK,FMN2,GPC5,HIF3A,LSAMP,GLIS3,PCDH9,PREX2,NPAS3,ZBTB20,SFXN5,PITPNC1,ITPR2,SLC4A4,ATP1A2,PARD3B,FGFR3,ABLIM1
2.071e-04	-8.48	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	42	16828	49	PITPNC1,ITPR2,SLC4A4,SFXN5,FGFR3,ABLIM1,ATP1A2,PARD3B,GLIS3,LSAMP,HIF3A,ZBTB20,NPAS3,PCDH9,PREX2,TRPS1,GPM6A,PTPRZ1,CDH20,GPC5,FMN2,TNIK,SLC1A3,CTNND2,CPE,RORA,NEBL,NTRK2,LIFR,MACF1,AHCYL2,NTM,FBXL7,ATP13A4,NRXN1,SLC1A2,BMPR1B,SOX5,RYR3,NKAIN3,NFIA,DTNA
2.117e-04	-8.46	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	34	16828	49	ATP13A4,FBXL7,AHCYL2,GLUD1,SPARCL1,NHSL1,MACF1,LIFR,NKAIN3,RYR3,SOX5,BMPR1B,SLC1A2,PCDH9,PREX2,LSAMP,GLIS3,ABLIM1,PARD3B,ITPR2,SFXN5,NTRK2,RORA,CPE,NEBL,MAML2,FMN2,TNIK,GPC5,CTNND2,SLC1A3,PTPRZ1,GPM6A,CDH20
2.152e-04	-8.44	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	4	10285	29	AHCYL2,SLC1A3,SLC1A2,SLC4A4
2.276e-04	-8.39	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	8	18094	48	GPM6A,SLC4A4,RYR3,SLC1A2,ATP13A4,ITPR2,SLC1A3,ATP1A2
2.300e-04	-8.38	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	45	16828	49	SPARCL1,LIFR,FBXL7,DTNA,RYR3,BMPR1B,PARD3B,ATP1A2,FGFR3,SFXN5,SLC4A4,PITPNC1,CST3,ZBTB20,HIF3A,GLIS3,LSAMP,CTNND2,SLC1A3,FMN2,MAML2,GPC5,PTPRZ1,NEBL,NHSL1,MACF1,ATP13A4,GLUD1,NTM,NRXN1,NFIA,SOX5,SLC1A2,ABLIM1,ITPR2,PCDH9,PREX2,NPAS3,TNIK,CDH20,GPM6A,TRPS1,NTRK2,RORA,CPE
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	LSAMP,NTM
2.328e-04	-8.37	cervix	COSMIC cancer mutations	cervix	11793	45	16828	49	ATP13A4,NTM,GLUD1,NHSL1,MACF1,NFIA,SLC1A2,SOX5,NRXN1,NPAS3,PREX2,PCDH9,ABLIM1,ITPR2,NTRK2,CPE,RORA,TNIK,TRPS1,GPM6A,CDH20,FBXL7,SPARCL1,LIFR,DTNA,BMPR1B,RYR3,ZBTB20,CST3,LSAMP,GLIS3,HIF3A,FGFR3,ATP1A2,PARD3B,PITPNC1,SLC4A4,SFXN5,NEBL,MAML2,GPC5,FMN2,SLC1A3,CTNND2,PTPRZ1
2.383e-04	-8.34	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	29	16828	49	DTNA,NKAIN3,SOX5,RYR3,ATP13A4,FBXL7,GLUD1,NTM,AHCYL2,MACF1,LIFR,NTRK2,NEBL,SLC1A3,CTNND2,GPC5,MAML2,FMN2,CDH20,GPM6A,PTPRZ1,TRPS1,CST3,NPAS3,LSAMP,PARD3B,ATP1A2,SLC4A4,ITPR2
2.383e-04	-8.34	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	29	16828	49	GLUD1,NTM,AHCYL2,FBXL7,ATP13A4,MACF1,LIFR,SOX5,RYR3,DTNA,NKAIN3,LSAMP,CST3,NPAS3,SLC4A4,ITPR2,PARD3B,ATP1A2,NEBL,NTRK2,CDH20,GPM6A,PTPRZ1,TRPS1,SLC1A3,CTNND2,FMN2,GPC5,MAML2
2.551e-04	-8.27	acidic amino acid transport	biological process	GO:0015800	45	3	18204	50	NTRK2,SLC1A2,SLC1A3
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	44	SLC1A3,SLC1A2
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	44	SLC1A2,SLC1A3
2.833e-04	-8.17	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	35	16828	49	SFXN5,ITPR2,SLC4A4,ATP1A2,FGFR3,ABLIM1,LSAMP,GLIS3,PCDH9,PREX2,CDH20,TRPS1,PTPRZ1,GPM6A,SLC1A3,CTNND2,MAML2,FMN2,TNIK,GPC5,NEBL,CPE,RORA,NTRK2,LIFR,MACF1,NHSL1,AHCYL2,ATP13A4,FBXL7,SLC1A2,BMPR1B,RYR3,SOX5,NKAIN3
3.003e-04	-8.11	monoatomic ion transmembrane transport	biological process	GO:0034220	804	9	18204	50	SLC1A2,SLC1A3,RYR3,ATP13A4,ITPR2,GPM6A,ATP1A2,SFXN5,SLC4A4
3.165e-04	-8.06	central nervous system development	biological process	GO:0007417	995	10	18204	50	SLC1A2,RORA,MSI2,PCDH9,CTNNA2,BMPR1B,GLUD1,NTRK2,ATP1A2,PTPRZ1
3.170e-04	-8.06	MIR_dom_sf	interpro domains	IPR036300	10	2	18521	50	RYR3,ITPR2
3.170e-04	-8.06	MIR_motif	interpro domains	IPR016093	10	2	18521	50	RYR3,ITPR2
3.281e-04	-8.02	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	50	NTRK2,ATP1A2
3.281e-04	-8.02	action potential propagation	biological process	GO:0098870	10	2	18204	50	ATP1A2,NTRK2
3.281e-04	-8.02	cellular response to cocaine	biological process	GO:0071314	10	2	18204	50	SLC1A3,SLC1A2
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	PREX2,RYR3,SOX5,SLC1A2
3.407e-04	-7.98	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	2	10285	29	AHCYL2,SLC4A4
3.432e-04	-7.98	MIR	pfam domains	PF02815	10	2	17795	50	ITPR2,RYR3
3.766e-04	-7.88	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	29	16828	49	TRPS1,PTPRZ1,GPM6A,CDH20,FMN2,MAML2,GPC5,CTNND2,SLC1A3,RORA,NEBL,NTRK2,ITPR2,FGFR3,PARD3B,LSAMP,GLIS3,NPAS3,PREX2,PCDH9,SLC1A2,RYR3,SOX5,NFIA,NKAIN3,MACF1,SPARCL1,NHSL1,FBXL7
3.838e-04	-7.87	EDTRNSPORT	prints domains	PR00173	7	2	5227	23	SLC1A3,SLC1A2
4.003e-04	-7.82	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	50	SLC1A3,SLC1A2
4.003e-04	-7.82	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	50	SLC1A3,SLC1A2
4.146e-04	-7.79	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	50	BMPR1B,TRPS1,SOX5
4.404e-04	-7.73	Ig_I-set	interpro domains	IPR013098	132	4	18521	50	FGFR3,NTRK2,NTM,LSAMP
4.466e-04	-7.71	neuron projection	cellular component	GO:0043005	1331	11	19108	49	CTNND2,SLC1A3,ATP1A2,PCDH9,CTNNA2,GPM6A,DTNA,SLC1A2,AHCYL2,NTRK2,BMPR1B
4.673e-04	-7.67	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	15	16828	49	ITPR2,MACF1,FGFR3,ABLIM1,LSAMP,PREX2,PCDH9,TRPS1,PTPRZ1,GPM6A,FMN2,GPC5,NEBL,RORA,MSI2
4.698e-04	-7.66	amino acid transport	biological process	GO:0006865	132	4	18204	50	SFXN5,NTRK2,SLC1A3,SLC1A2
4.795e-04	-7.64	auditory behavior	biological process	GO:0031223	12	2	18204	50	SLC1A3,NRXN1
4.806e-04	-7.64	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	33	16828	49	LSAMP,ZBTB20,NPAS3,CST3,PREX2,PCDH9,PITPNC1,ITPR2,SLC4A4,SFXN5,FGFR3,ATP1A2,PARD3B,RORA,NEBL,NTRK2,TRPS1,PTPRZ1,CDH20,MAML2,FMN2,CTNND2,NTM,ATP13A4,FBXL7,LIFR,MACF1,NHSL1,SLC1A2,SOX5,RYR3,NFIA,NRXN1
4.806e-04	-7.64	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	33	16828	49	NFIA,SLC1A2,RYR3,SOX5,NRXN1,ATP13A4,FBXL7,NTM,NHSL1,LIFR,MACF1,NTRK2,NEBL,RORA,CTNND2,FMN2,MAML2,CDH20,TRPS1,PTPRZ1,PCDH9,PREX2,NPAS3,ZBTB20,CST3,LSAMP,ATP1A2,PARD3B,FGFR3,SFXN5,PITPNC1,ITPR2,SLC4A4
5.053e-04	-7.59	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	3	10285	29	ATP1A2,ITPR2,RYR3
5.060e-04	-7.59	cell body	cellular component	GO:0044297	556	7	19108	49	GPM6A,CTNND2,SLC1A3,NRXN1,SLC1A2,ATP1A2,BMPR1B
5.115e-04	-7.58	I-set	pfam domains	PF07679	132	4	17795	50	LSAMP,NTM,NTRK2,FGFR3
5.522e-04	-7.50	neuron projection development	biological process	GO:0031175	693	8	18204	50	PTPRZ1,PREX2,CTNND2,BMPR1B,NRXN1,GPM6A,CTNNA2,TNIK
5.545e-04	-7.50	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	13	16828	49	FMN2,CTNND2,PTPRZ1,CDH20,DTNA,CPE,RORA,FGFR3,ABLIM1,PARD3B,LIFR,MACF1,PREX2
5.545e-04	-7.50	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	13	16828	49	PREX2,PARD3B,ABLIM1,FGFR3,MACF1,LIFR,DTNA,RORA,CPE,CTNND2,FMN2,CDH20,PTPRZ1
5.566e-04	-7.49	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	42	16828	49	GLIS3,LSAMP,PCDH9,PREX2,CST3,ZBTB20,NPAS3,SFXN5,ITPR2,SLC4A4,ATP1A2,PARD3B,FGFR3,NEBL,CPE,RORA,MSI2,NTRK2,CDH20,TRPS1,PTPRZ1,SLC1A3,CTNND2,MAML2,FMN2,GPC5,TNIK,GLUD1,AHCYL2,NTM,FBXL7,ATP13A4,PTGDS,LIFR,MACF1,NHSL1,BMPR1B,SLC1A2,SOX5,RYR3,DTNA,NRXN1
5.629e-04	-7.48	MIR	prosite domains	PS50919	10	2	12186	44	ITPR2,RYR3
5.865e-04	-7.44	neurotransmitter transport	biological process	GO:0006836	140	4	18204	50	SLC1A3,SLC1A2,ATP1A2,NRXN1
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A3,SLC1A2
6.412e-04	-7.35	cell adhesion molecule binding	molecular function	GO:0050839	560	7	18094	48	PTPRZ1,NRXN1,CDH20,CPE,CTNNA2,MACF1,CTNND2
6.545e-04	-7.33	NAKATPASE	prints domains	PR00121	9	2	5227	23	ATP1A2,ATP13A4
6.588e-04	-7.33	mechanosensory behavior	biological process	GO:0007638	14	2	18204	50	SLC1A3,NRXN1
6.588e-04	-7.33	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	50	SLC4A4,ATP1A2
6.866e-04	-7.28	adult behavior	biological process	GO:0030534	146	4	18204	50	NRXN1,PREX2,ATP1A2,SLC1A2
6.932e-04	-7.27	cell projection	cellular component	GO:0042995	2398	15	19108	49	NTRK2,MACF1,CTNNA2,ATP1A2,PCDH9,CTNND2,FMN2,AHCYL2,SLC1A2,BMPR1B,ABLIM1,DTNA,GPM6A,SLC1A3,NRXN1
6.985e-04	-7.27	cell development	biological process	GO:0048468	2236	15	18204	50	CTNNA2,TNIK,NEBL,PTPRZ1,CTNND2,BMPR1B,NTRK2,MSI2,NRXN1,GPM6A,SLC1A3,RORA,PREX2,NTM,FMN2
7.220e-04	-7.23	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	50	CTNNA2,PREX2,CTNND2
7.282e-04	-7.22	MIR	smart domains	SM00472	10	2	9717	40	ITPR2,RYR3
7.592e-04	-7.18	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	2	19454	50	MACF1,CPE
7.721e-04	-7.17	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	5	18094	48	SLC1A2,ATP13A4,SLC4A4,SLC1A3,ATP1A2
7.916e-04	-7.14	face	COSMIC cancer mutations	face	2139	15	16828	49	PREX2,PCDH9,LSAMP,ABLIM1,FGFR3,MACF1,ITPR2,MSI2,NEBL,RORA,GPC5,FMN2,PTPRZ1,GPM6A,TRPS1
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	SLC4A4,SLC1A2,ATP1A2,SLC1A3
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	ZBTB20,LSAMP
8.516e-04	-7.07	spindle	COSMIC cancer mutations	spindle	386	6	16828	49	MACF1,FGFR3,CTNND2,CPE,PREX2,PCDH9
8.632e-04	-7.05	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	7	18094	48	GPM6A,SLC1A2,SLC4A4,ATP1A2,SLC1A3,ITPR2,RYR3
8.795e-04	-7.04	retina development in camera-type eye	biological process	GO:0060041	156	4	18204	50	GPM6A,NFIA,NTRK2,BMPR1B
8.890e-04	-7.03	cellular response to endogenous stimulus	biological process	GO:0071495	1135	10	18204	50	RYR3,SLC1A3,SLC1A2,NFIA,ITPR2,BMPR1B,SOX5,NTRK2,ATP1A2,FGFR3
9.444e-04	-6.96	cell adhesion	biological process	GO:0007155	942	9	18204	50	NTM,CTNND2,CDH20,LSAMP,SPARCL1,CTNNA2,PCDH9,PARD3B,NRXN1
9.763e-04	-6.93	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	5	16828	49	SLC1A2,SOX5,RYR3,FGFR3,PREX2
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	LSAMP,NTM,GPM6A
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A2,SLC1A3
1.026e-03	-6.88	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	2	18094	48	ITPR2,RYR3
1.030e-03	-6.88	FLOT1 (flotillin 1)	protein interactions	10211	453	6	19454	50	FMN2,MACF1,SOX5,ABLIM1,DTNA,GLUD1
1.043e-03	-6.87	synapse	cellular component	GO:0045202	1473	11	19108	49	SPARCL1,TNIK,GPM6A,DTNA,NTRK2,SLC1A2,NRXN1,SLC1A3,CTNND2,PTPRZ1,ATP1A2
1.059e-03	-6.85	regulation of cartilage development	biological process	GO:0061035	73	3	18204	50	SOX5,TRPS1,BMPR1B
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP13A4,ATP1A2
1.066e-03	-6.84	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	7	16828	49	RYR3,SLC4A4,LIFR,TRPS1,CTNND2,FBXL7,NTRK2
1.089e-03	-6.82	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	7	16828	49	RYR3,FBXL7,NTRK2,TRPS1,LIFR,SLC4A4,CTNND2
1.096e-03	-6.82	transporter activity	molecular function	GO:0005215	1211	10	18094	48	PITPNC1,ITPR2,ATP1A2,SLC1A3,SFXN5,ATP13A4,SLC1A2,RYR3,SLC4A4,GPM6A
1.112e-03	-6.80	monoatomic ion transport	biological process	GO:0006811	964	9	18204	50	ATP13A4,SLC1A3,RYR3,SLC1A2,ITPR2,GPM6A,SFXN5,ATP1A2,SLC4A4
1.150e-03	-6.77	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	50	ATP13A4,ATP1A2
1.179e-03	-6.74	RHOB (ras homolog family member B)	protein interactions	388	832	8	19454	50	AHCYL2,ABLIM1,DTNA,TNIK,SLC1A3,FMN2,MACF1,PARD3B
1.186e-03	-6.74	PAS_fold	interpro domains	IPR013767	19	2	18521	50	HIF3A,NPAS3
1.209e-03	-6.72	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	42	16828	49	MACF1,LIFR,NHSL1,NTM,AHCYL2,GLUD1,PTGDS,ATP13A4,FBXL7,NRXN1,RYR3,SOX5,BMPR1B,SLC1A2,DTNA,SLC4A4,ITPR2,SFXN5,FGFR3,PARD3B,ATP1A2,GLIS3,LSAMP,NPAS3,CST3,ZBTB20,PREX2,PCDH9,PTPRZ1,TRPS1,CDH20,FMN2,GPC5,MAML2,TNIK,SLC1A3,CTNND2,RORA,CPE,NEBL,NTRK2,MSI2
1.226e-03	-6.70	GSC (goosecoid homeobox)	protein interactions	145258	82	3	19454	50	SOX5,NFIA,TRPS1
1.227e-03	-6.70	cartilage condensation	biological process	GO:0001502	19	2	18204	50	BMPR1B,SOX5
1.235e-03	-6.70	response to endogenous stimulus	biological process	GO:0009719	1402	11	18204	50	NFIA,ITPR2,PTGDS,RYR3,SLC1A3,SLC1A2,FGFR3,BMPR1B,SOX5,ATP1A2,NTRK2
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC1A3,SLC4A4,SLC1A2
1.283e-03	-6.66	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	50	SLC1A2,SLC1A3,NTRK2
1.283e-03	-6.66	PAS	pfam domains	PF00989	19	2	17795	50	HIF3A,NPAS3
1.290e-03	-6.65	cartilage development	biological process	GO:0051216	173	4	18204	50	BMPR1B,SOX5,NFIA,FGFR3
1.293e-03	-6.65	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	3	18094	48	NTRK2,BMPR1B,FGFR3
1.314e-03	-6.63	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	8	16828	49	ITPR2,TRPS1,SLC1A3,CTNND2,SOX5,NEBL,NTRK2,DTNA
1.332e-03	-6.62	mucosal	COSMIC cancer mutations	mucosal	2009	14	16828	49	LIFR,ABLIM1,SPARCL1,FGFR3,ATP1A2,PREX2,ATP13A4,PCDH9,FMN2,CTNND2,RORA,CPE,NEBL,BMPR1B
1.332e-03	-6.62	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	14	16828	49	PREX2,ATP13A4,PCDH9,LIFR,ATP1A2,SPARCL1,ABLIM1,FGFR3,NEBL,BMPR1B,RORA,CPE,CTNND2,FMN2
1.357e-03	-6.60	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	14	19108	49	ATP1A2,PCDH9,CTNND2,NTRK2,MACF1,CTNNA2,SLC1A3,FMN2,SLC1A2,AHCYL2,BMPR1B,ABLIM1,GPM6A,DTNA
1.361e-03	-6.60	adherens junction	cellular component	GO:0005912	188	4	19108	49	CTNND2,CTNNA2,CDH20,PARD3B
1.361e-03	-6.60	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	50	BMPR1B,SOX5
1.361e-03	-6.60	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	50	SLC1A2,SLC1A3
1.398e-03	-6.57	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	32	16828	49	NKAIN3,SLC1A2,BMPR1B,SOX5,RYR3,FBXL7,ATP13A4,AHCYL2,NHSL1,LIFR,MACF1,NTRK2,NEBL,CPE,RORA,SLC1A3,CTNND2,GPC5,MAML2,FMN2,CDH20,GPM6A,PCDH9,PREX2,LSAMP,GLIS3,ATP1A2,FGFR3,ABLIM1,SFXN5,ITPR2,SLC4A4
1.425e-03	-6.55	behavior	biological process	GO:0007610	619	7	18204	50	NRXN1,SLC1A2,SLC1A3,PTPRZ1,PREX2,ATP1A2,NTRK2
1.439e-03	-6.54	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	22	16828	49	CTNND2,NRXN1,TNIK,GPC5,PTPRZ1,TRPS1,DTNA,NFIA,SOX5,RYR3,CPE,ATP1A2,SPARCL1,FGFR3,MACF1,ITPR2,LIFR,ATP13A4,PCDH9,HIF3A,GLIS3,LSAMP
1.499e-03	-6.50	neuronal cell body	cellular component	GO:0043025	489	6	19108	49	NRXN1,GPM6A,SLC1A3,CTNND2,BMPR1B,ATP1A2
1.502e-03	-6.50	positive regulation of glycolytic process	biological process	GO:0045821	21	2	18204	50	SLC4A4,ZBTB20
1.502e-03	-6.50	positive regulation of nucleotide catabolic process	biological process	GO:0030813	21	2	18204	50	ZBTB20,SLC4A4
1.502e-03	-6.50	cell aggregation	biological process	GO:0098743	21	2	18204	50	BMPR1B,SOX5
1.502e-03	-6.50	positive regulation of purine nucleotide catabolic process	biological process	GO:0033123	21	2	18204	50	ZBTB20,SLC4A4
1.563e-03	-6.46	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	42	16828	49	DTNA,NFIA,NKAIN3,BMPR1B,SLC1A2,RYR3,SOX5,NRXN1,ATP13A4,FBXL7,AHCYL2,NTM,NHSL1,SPARCL1,LIFR,MACF1,MSI2,NTRK2,NEBL,CPE,RORA,CTNND2,SLC1A3,FMN2,TNIK,GPC5,MAML2,CDH20,PTPRZ1,PREX2,PCDH9,NPAS3,HIF3A,GLIS3,LSAMP,ATP1A2,PARD3B,FGFR3,ABLIM1,SFXN5,ITPR2,SLC4A4
1.594e-03	-6.44	DEP_dom	interpro domains	IPR000591	22	2	18521	50	FMN2,PREX2
1.620e-03	-6.43	OCLN (occludin)	protein interactions	100506658	495	6	19454	50	TNIK,ABLIM1,DTNA,FMN2,MACF1,NTRK2
1.632e-03	-6.42	cellular response to organic cyclic compound	biological process	GO:0071407	464	6	18204	50	ITPR2,SLC1A2,RYR3,SLC1A3,RORA,ATP1A2
1.644e-03	-6.41	chondrocyte differentiation	biological process	GO:0002062	85	3	18204	50	FGFR3,SOX5,BMPR1B
1.649e-03	-6.41	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	50	SLC1A3,ATP1A2
1.664e-03	-6.40	monoatomic cation transmembrane transport	biological process	GO:0098655	636	7	18204	50	ATP13A4,RYR3,SLC1A3,GPM6A,ITPR2,ATP1A2,SLC4A4
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A3,SLC1A2
1.689e-03	-6.38	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	12	16828	49	PTPRZ1,TRPS1,NRXN1,GPC5,SOX5,RORA,SLC4A4,MACF1,ATP1A2,FGFR3,LSAMP,ATP13A4
1.714e-03	-6.37	leg	COSMIC cancer mutations	leg	969	9	16828	49	ATP13A4,ZBTB20,NEBL,HIF3A,NTM,FGFR3,FMN2,PTPRZ1,SLC4A4
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	DTNA,GLUD1,RYR3,ATP1A2
1.832e-03	-6.30	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	48	ATP1A2,ATP13A4
1.832e-03	-6.30	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	48	ATP1A2,ATP13A4
1.848e-03	-6.29	cell surface	cellular component	GO:0009986	896	8	19108	49	FGFR3,GPC5,SLC1A2,SLC4A4,NRXN1,SLC1A3,LIFR,ATP1A2
1.854e-03	-6.29	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	4	19454	50	NRXN1,PARD3B,ABLIM1,DTNA
1.911e-03	-6.26	cell-cell junction	cellular component	GO:0005911	513	6	19108	49	ATP1A2,CDH20,PARD3B,PCDH9,CTNND2,CTNNA2
1.912e-03	-6.26	Cation_ATPase_N	smart domains	SM00831	16	2	9717	40	ATP1A2,ATP13A4
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
2.021e-03	-6.20	skin-face-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-face-malignant_melanoma-lentigo_maligna	23	2	16828	49	PREX2,FGFR3
2.023e-03	-6.20	NRCAM (neuronal cell adhesion molecule)	protein interactions	4897	26	2	19454	50	GLUD1,MACF1
2.039e-03	-6.20	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	29	SLC1A2,SLC1A3
2.041e-03	-6.19	export from cell	biological process	GO:0140352	485	6	18204	50	SLC4A4,NRXN1,NTRK2,ATP1A2,CPE,PTGDS
2.130e-03	-6.15	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	50	SLC1A2,SLC1A3
2.146e-03	-6.14	synapse organization	biological process	GO:0050808	333	5	18204	50	GPM6A,NFIA,SPARCL1,CTNND2,NRXN1
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	CDH20,DTNA,CTNNA2
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	DTNA,ABLIM1
2.185e-03	-6.13	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	7	19454	50	MACF1,ABLIM1,DTNA,TNIK,SLC1A3,MSI2,FMN2
2.196e-03	-6.12	adenoma	COSMIC cancer mutations	adenoma	2873	17	16828	49	HIF3A,PCDH9,NPAS3,ZBTB20,MACF1,LIFR,FGFR3,SOX5,RYR3,BMPR1B,NEBL,NTRK2,CDH20,GPM6A,PTPRZ1,CTNND2,GPC5
2.200e-03	-6.12	EZR (ezrin)	protein interactions	7430	526	6	19454	50	MACF1,TNIK,DTNA,AHCYL2,ABLIM1,NEBL
2.259e-03	-6.09	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	7	10285	29	ATP1A2,RYR3,SLC1A3,SLC1A2,ATP13A4,SLC4A4,AHCYL2
2.282e-03	-6.08	transmembrane transporter activity	molecular function	GO:0022857	1110	9	18094	48	RYR3,SLC4A4,GPM6A,ITPR2,SLC1A3,ATP1A2,SFXN5,ATP13A4,SLC1A2
2.302e-03	-6.07	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	32	16828	49	SPARCL1,LIFR,MACF1,PTGDS,ATP13A4,NRXN1,NKAIN3,DTNA,SOX5,RYR3,FGFR3,ABLIM1,ATP1A2,PARD3B,ITPR2,SLC4A4,ZBTB20,NPAS3,CST3,PREX2,GLIS3,HIF3A,TNIK,MAML2,FMN2,CTNND2,SLC1A3,TRPS1,PTPRZ1,NTRK2,RORA,NEBL
2.304e-03	-6.07	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	50	SLC1A3,SLC1A2
2.341e-03	-6.06	actin filament binding	molecular function	GO:0051015	211	4	18094	48	CTNNA2,ABLIM1,MACF1,NEBL
2.414e-03	-6.03	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	11	16828	49	RYR3,NEBL,PREX2,CDH20,PTPRZ1,MACF1,LIFR,CTNND2,NRXN1,FGFR3,FMN2
2.414e-03	-6.03	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	11	16828	49	RYR3,NEBL,PREX2,CDH20,MACF1,PTPRZ1,LIFR,CTNND2,NRXN1,FMN2,FGFR3
2.455e-03	-6.01	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	5	19454	50	TNIK,GLUD1,AHCYL2,ABLIM1,NTRK2
2.504e-03	-5.99	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	16	16828	49	ATP1A2,LIFR,ATP13A4,PCDH9,PREX2,LSAMP,NRXN1,SLC1A3,CTNND2,MAML2,CDH20,TRPS1,PTPRZ1,NEBL,RYR3,SOX5
2.512e-03	-5.99	cell differentiation	biological process	GO:0030154	3645	19	18204	50	CTNNA2,NFIA,NHSL1,TNIK,FGFR3,CTNND2,NEBL,PTPRZ1,NTRK2,SOX5,BMPR1B,GPM6A,NRXN1,MSI2,RORA,SLC1A3,FMN2,NTM,PREX2
2.537e-03	-5.98	cellular developmental process	biological process	GO:0048869	3648	19	18204	50	SLC1A3,RORA,MSI2,NRXN1,GPM6A,PREX2,NTM,FMN2,TNIK,NHSL1,NFIA,CTNNA2,BMPR1B,SOX5,NTRK2,PTPRZ1,NEBL,CTNND2,FGFR3
2.570e-03	-5.96	fgf3.L (fibroblast growth factor 3 L homeolog)	protein interactions	373669	1	1	19454	50	FGFR3
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	50	NRXN1
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Sh2b1 (SH2B adaptor protein 1)	protein interactions	20399	1	1	19454	50	FGFR3
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.593e-03	-5.95	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	44	ATP1A2,ATP13A4
2.602e-03	-5.95	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	7	18094	48	ITPR2,SLC1A3,RYR3,ATP1A2,SLC4A4,GPM6A,SLC1A2
2.614e-03	-5.95	response to alkaloid	biological process	GO:0043279	100	3	18204	50	SLC1A3,SLC1A2,RYR3
2.645e-03	-5.93	KLF3 (KLF transcription factor 3)	protein interactions	51274	225	4	19454	50	TRPS1,NFIA,GLUD1,SOX5
2.653e-03	-5.93	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	48	NTRK2
2.673e-03	-5.92	ligand-gated calcium channel activity	molecular function	GO:0099604	29	2	18094	48	ITPR2,RYR3
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A3,SLC1A2
2.698e-03	-5.92	EN1 (engrailed homeobox 1)	protein interactions	2019	108	3	19454	50	TRPS1,NFIA,AHCYL2
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	M14_CPE_CPD	interpro domains	IPR034232	1	1	18521	50	CPE
2.700e-03	-5.91	LIFR_N	interpro domains	IPR040901	1	1	18521	50	LIFR
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	MAML2_TAD	interpro domains	IPR048452	1	1	18521	50	MAML2
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	ATP13A4,GLUD1,NTM,NHSL1,MACF1,NKAIN3,NFIA,SLC1A2,SOX5,NRXN1,PCDH9,PREX2,NPAS3,ABLIM1,ITPR2,NTRK2,CPE,RORA,TNIK,CDH20,TRPS1,GPM6A,FBXL7,PTGDS,AHCYL2,SPARCL1,LIFR,DTNA,BMPR1B,RYR3,CST3,ZBTB20,HIF3A,LSAMP,GLIS3,ATP1A2,PARD3B,FGFR3,SFXN5,PITPNC1,SLC4A4,NEBL,CTNND2,SLC1A3,GPC5,MAML2,FMN2,PTPRZ1
2.747e-03	-5.90	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	50	CST3
2.747e-03	-5.90	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	50	CST3
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	50	NTRK2
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	50	NTRK2
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.747e-03	-5.90	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	50	FMN2
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	NPAS3,PCDH9,PREX2,ABLIM1,ITPR2,NTRK2,RORA,CPE,TNIK,GPM6A,TRPS1,CDH20,ATP13A4,NTM,GLUD1,NHSL1,MACF1,NKAIN3,NFIA,SOX5,SLC1A2,NRXN1,CST3,ZBTB20,GLIS3,LSAMP,HIF3A,FGFR3,PARD3B,ATP1A2,SLC4A4,PITPNC1,SFXN5,NEBL,GPC5,MAML2,FMN2,SLC1A3,CTNND2,PTPRZ1,PTGDS,FBXL7,AHCYL2,SPARCL1,LIFR,DTNA,RYR3,BMPR1B
2.810e-03	-5.87	FGFR3_TM	pfam domains	PF21165	1	1	17795	50	FGFR3
2.810e-03	-5.87	MAML2_TAD	pfam domains	PF20804	1	1	17795	50	MAML2
2.810e-03	-5.87	LIFR_N	pfam domains	PF18207	1	1	17795	50	LIFR
2.820e-03	-5.87	t(4;14) translocations of FGFR3	REACTOME pathways	R-HSA-2033515	1	1	10285	29	FGFR3
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CDH20,CTNNA2
2.862e-03	-5.86	ACTB (actin beta)	protein interactions	60	958	8	19454	50	ABLIM1,AHCYL2,DTNA,FMN2,NEBL,NHSL1,MACF1,SFXN5
2.870e-03	-5.85	SH2B1 (SH2B adaptor protein 1)	protein interactions	25970	31	2	19454	50	FGFR3,NTRK2
2.991e-03	-5.81	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	3	19454	50	TRPS1,SOX5,NFIA
3.002e-03	-5.81	neural precursor cell proliferation	biological process	GO:0061351	105	3	18204	50	SOX5,RORA,NFIA
3.041e-03	-5.80	-	gene3d domains	6.10.250.1740	1	1	14470	44	FGFR3
3.051e-03	-5.79	intracellularly ligand-gated monoatomic ion channel activity	molecular function	GO:0005217	31	2	18094	48	RYR3,ITPR2
3.057e-03	-5.79	NXPH2 (neurexophilin 2)	protein interactions	11249	32	2	19454	50	PCDH9,NRXN1
3.062e-03	-5.79	L-glutamate import	biological process	GO:0051938	30	2	18204	50	SLC1A3,SLC1A2
3.072e-03	-5.79	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	11	16828	49	PTPRZ1,MACF1,PARD3B,FGFR3,GPC5,FMN2,RYR3,PREX2,DTNA,PCDH9,NPAS3
3.104e-03	-5.78	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	46	16828	49	DTNA,RYR3,BMPR1B,LIFR,FBXL7,PTGDS,AHCYL2,SLC1A3,CTNND2,MAML2,FMN2,GPC5,PTPRZ1,MSI2,NEBL,PARD3B,ATP1A2,FGFR3,SFXN5,SLC4A4,PITPNC1,CST3,ZBTB20,HIF3A,GLIS3,LSAMP,NRXN1,NKAIN3,NFIA,SOX5,SLC1A2,NHSL1,MACF1,ATP13A4,NTM,TNIK,CDH20,GPM6A,TRPS1,NTRK2,RORA,ABLIM1,ITPR2,PREX2,PCDH9,NPAS3
3.144e-03	-5.76	ORF3b (ORF3b protein)	protein interactions	1489670	114	3	19454	50	MACF1,PCDH9,ZBTB20
3.234e-03	-5.73	cell junction organization	biological process	GO:0034330	532	6	18204	50	CDH20,CTNND2,SPARCL1,GPM6A,NRXN1,NFIA
3.305e-03	-5.71	Pancreatic secretion	KEGG pathways	hsa04972	95	3	7161	23	ATP1A2,SLC4A4,ITPR2
3.305e-03	-5.71	Pancreatic secretion	KEGG pathways	ko04972	95	3	7161	23	ITPR2,SLC4A4,ATP1A2
3.349e-03	-5.70	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	19	16828	49	NHSL1,ATP1A2,ABLIM1,SPARCL1,MACF1,SLC4A4,PCDH9,PREX2,ZBTB20,CTNND2,GPC5,MAML2,TNIK,FMN2,GPM6A,PTPRZ1,RYR3,SOX5,NEBL
3.371e-03	-5.69	middle_third	COSMIC cancer mutations	middle_third	3533	19	16828	49	NEBL,RYR3,SOX5,GPC5,FMN2,TNIK,MAML2,CTNND2,PTPRZ1,GPM6A,ZBTB20,PREX2,PCDH9,ABLIM1,SPARCL1,ATP1A2,NHSL1,SLC4A4,MACF1
3.415e-03	-5.68	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	50	ATP13A4,ATP1A2
3.430e-03	-5.68	lentigo_maligna	COSMIC cancer mutations	lentigo_maligna	30	2	16828	49	PREX2,FGFR3
3.430e-03	-5.68	skin-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-malignant_melanoma-acral_lentiginous	30	2	16828	49	FGFR3,PREX2
3.445e-03	-5.67	brain development	biological process	GO:0007420	724	7	18204	50	RORA,SLC1A2,PCDH9,CTNNA2,ATP1A2,NTRK2,GLUD1
3.479e-03	-5.66	positive regulation of ATP metabolic process	biological process	GO:1903580	32	2	18204	50	ZBTB20,SLC4A4
3.479e-03	-5.66	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	50	SOX5,BMPR1B
3.479e-03	-5.66	transepithelial transport	biological process	GO:0070633	32	2	18204	50	SLC1A3,SLC1A2
3.637e-03	-5.62	Cation_ATPase	pfam domains	PF13246	32	2	17795	50	ATP13A4,ATP1A2
3.649e-03	-5.61	TPRA1 (transmembrane protein adipocyte associated 1)	protein interactions	131601	35	2	19454	50	ITPR2,BMPR1B
3.674e-03	-5.61	cell-cell adhesion	biological process	GO:0098609	546	6	18204	50	CTNNA2,PCDH9,NRXN1,CTNND2,CDH20,SPARCL1
3.688e-03	-5.60	calcium channel activity	molecular function	GO:0005262	117	3	18094	48	GPM6A,RYR3,ITPR2
3.688e-03	-5.60	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	3	18094	48	SLC1A2,SLC4A4,SLC1A3
3.692e-03	-5.60	dendrite development	biological process	GO:0016358	113	3	18204	50	CTNNA2,PREX2,CTNND2
3.724e-03	-5.59	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	3	16828	49	HIF3A,NEBL,PARD3B
3.741e-03	-5.59	connective tissue development	biological process	GO:0061448	232	4	18204	50	SOX5,BMPR1B,FGFR3,NFIA
3.758e-03	-5.58	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	9	18204	50	ABLIM1,TNIK,CTNNA2,GPM6A,NRXN1,BMPR1B,PREX2,PTPRZ1,CTNND2
3.792e-03	-5.57	PAS-like_dom_sf	interpro domains	IPR035965	34	2	18521	50	NPAS3,HIF3A
3.792e-03	-5.57	PAS	interpro domains	IPR000014	34	2	18521	50	NPAS3,HIF3A
3.858e-03	-5.56	receptor complex	cellular component	GO:0043235	409	5	19108	49	BMPR1B,FGFR3,LIFR,NTRK2,ITPR2
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A2,SLC1A3
3.908e-03	-5.54	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	8	16828	49	ITPR2,PTPRZ1,ATP1A2,FGFR3,ABLIM1,SPARCL1,NPAS3,PTGDS
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	NTM,LSAMP,FGFR3,NTRK2
3.978e-03	-5.53	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	5	16828	49	MACF1,CPE,PREX2,CTNND2,PCDH9
4.071e-03	-5.50	HPCA (hippocalcin)	protein interactions	3208	37	2	19454	50	CST3,GPM6A
4.116e-03	-5.49	DELLA	smart domains	SM01129	1	1	9717	40	MACF1
4.238e-03	-5.46	extraskeletal	COSMIC cancer mutations	extraskeletal	903	8	16828	49	ITPR2,PTPRZ1,ATP1A2,FGFR3,SPARCL1,ABLIM1,PTGDS,NPAS3
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP13A4,ATP1A2
4.258e-03	-5.46	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	3	19454	50	MACF1,ABLIM1,DTNA
4.370e-03	-5.43	striated muscle contraction	biological process	GO:0006941	120	3	18204	50	ATP1A2,DTNA,RYR3
4.400e-03	-5.43	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	23	NTRK2
4.448e-03	-5.42	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	3	19454	50	ITPR2,ABLIM1,ZBTB20
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP1A2,ATP13A4
4.602e-03	-5.38	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	6	19454	50	TNIK,AHCYL2,ABLIM1,DTNA,FGFR3,NHSL1
4.603e-03	-5.38	organic anion transport	biological process	GO:0015711	398	5	18204	50	SLC4A4,SLC1A3,SLC1A2,SFXN5,NTRK2
4.605e-03	-5.38	regulation of synapse organization	biological process	GO:0050807	246	4	18204	50	GPM6A,CTNNA2,NRXN1,NTRK2
4.607e-03	-5.38	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	27	16828	49	NRXN1,NFIA,DTNA,SPARCL1,MACF1,ATP13A4,FMN2,GPC5,SLC1A3,TRPS1,PTPRZ1,GPM6A,CDH20,NTRK2,NEBL,FGFR3,ABLIM1,ATP1A2,PARD3B,ITPR2,SLC4A4,SFXN5,ZBTB20,PCDH9,PREX2,GLIS3,HIF3A
4.631e-03	-5.38	positive regulation of purine nucleotide metabolic process	biological process	GO:1900544	37	2	18204	50	ZBTB20,SLC4A4
4.631e-03	-5.38	positive regulation of nucleotide metabolic process	biological process	GO:0045981	37	2	18204	50	ZBTB20,SLC4A4
4.631e-03	-5.37	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	27	16828	49	NEBL,NTRK2,TRPS1,GPM6A,PTPRZ1,CDH20,GPC5,FMN2,SLC1A3,GLIS3,HIF3A,ZBTB20,PCDH9,PREX2,ITPR2,SLC4A4,SFXN5,FGFR3,ABLIM1,ATP1A2,PARD3B,NFIA,DTNA,NRXN1,ATP13A4,MACF1,SPARCL1
4.632e-03	-5.37	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	44	16828	49	CDH20,TRPS1,GPM6A,PTPRZ1,SLC1A3,CTNND2,TNIK,GPC5,FMN2,MAML2,NEBL,CPE,RORA,NTRK2,SFXN5,PITPNC1,ITPR2,ATP1A2,PARD3B,FGFR3,ABLIM1,HIF3A,LSAMP,GLIS3,PCDH9,PREX2,NPAS3,ZBTB20,NRXN1,SLC1A2,BMPR1B,SOX5,RYR3,NFIA,NKAIN3,LIFR,MACF1,NHSL1,SPARCL1,GLUD1,AHCYL2,NTM,ATP13A4,FBXL7
4.669e-03	-5.37	PAS	smart domains	SM00091	25	2	9717	40	HIF3A,NPAS3
4.691e-03	-5.36	monoatomic cation transport	biological process	GO:0006812	766	7	18204	50	ATP1A2,SLC4A4,ATP13A4,RYR3,SLC1A3,GPM6A,ITPR2
4.705e-03	-5.36	plasma membrane region	cellular component	GO:0098590	1278	9	19108	49	NRXN1,SLC1A3,PARD3B,ATP1A2,GPM6A,TNIK,MACF1,SLC4A4,SLC1A2
4.753e-03	-5.35	endoplasmic reticulum	cellular component	GO:0005783	2051	12	19108	49	FMN2,AHCYL2,GLUD1,ITPR2,ATP13A4,RYR3,NRXN1,FGFR3,SPARCL1,ATP1A2,PTGDS,CST3
4.816e-03	-5.34	gallbladder	COSMIC cancer mutations	gallbladder	2821	16	16828	49	TRPS1,PTPRZ1,CTNND2,FMN2,TNIK,RYR3,NKAIN3,ITPR2,PITPNC1,SLC4A4,MACF1,NHSL1,FGFR3,SPARCL1,PREX2,PCDH9
4.816e-03	-5.34	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	16	16828	49	FGFR3,SPARCL1,NHSL1,ITPR2,PITPNC1,SLC4A4,MACF1,PCDH9,PREX2,TNIK,FMN2,CTNND2,TRPS1,PTPRZ1,NKAIN3,RYR3
4.880e-03	-5.32	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	50	SLC1A2,SLC1A3
4.915e-03	-5.32	cell projection organization	biological process	GO:0030030	1200	9	18204	50	ABLIM1,TNIK,NRXN1,GPM6A,CTNNA2,BMPR1B,PTPRZ1,PREX2,CTNND2
4.945e-03	-5.31	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	3	19454	50	NTM,GPM6A,CPE
4.963e-03	-5.31	head development	biological process	GO:0060322	774	7	18204	50	RORA,SLC1A2,CTNNA2,PCDH9,ATP1A2,NTRK2,GLUD1
4.969e-03	-5.30	intracellular chemical homeostasis	biological process	GO:0055082	581	6	18204	50	RYR3,SLC1A3,ATP13A4,ZBTB20,ATP1A2,SLC4A4
4.980e-03	-5.30	TAFA2 (TAFA chemokine like family member 2)	protein interactions	338811	41	2	19454	50	CPE,LIFR
4.988e-03	-5.30	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	5	16828	49	MAML2,FGFR3,NTRK2,TNIK,LIFR
4.988e-03	-5.30	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	5	16828	49	FGFR3,TNIK,NTRK2,MAML2,LIFR
4.988e-03	-5.30	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	5	16828	49	NTRK2,MAML2,FGFR3,TNIK,LIFR
4.988e-03	-5.30	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	5	16828	49	MAML2,FGFR3,NTRK2,TNIK,LIFR
4.988e-03	-5.30	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	5	16828	49	LIFR,FGFR3,TNIK,MAML2,NTRK2
5.014e-03	-5.30	regulation of synapse structure or activity	biological process	GO:0050803	252	4	18204	50	GPM6A,CTNNA2,NRXN1,NTRK2
5.042e-03	-5.29	testis	COSMIC cancer mutations	testis	733	7	16828	49	PREX2,NTRK2,TNIK,FGFR3,BMPR1B,MACF1,TRPS1
5.049e-03	-5.29	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	3	19454	50	DTNA,ABLIM1,NTRK2
5.049e-03	-5.29	Myo1c (myosin IC)	protein interactions	17913	135	3	19454	50	ABLIM1,ITPR2,TRPS1
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	DTNA,MACF1,SPARCL1,RYR3
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	50	SLC1A3,ATP1A2
5.135e-03	-5.27	prostate	COSMIC cancer mutations	prostate	13883	47	16828	49	ATP1A2,PARD3B,FGFR3,SFXN5,PITPNC1,SLC4A4,ZBTB20,HIF3A,GLIS3,LSAMP,SLC1A3,CTNND2,GPC5,FMN2,MAML2,PTPRZ1,MSI2,NEBL,SPARCL1,LIFR,FBXL7,AHCYL2,DTNA,BMPR1B,RYR3,ABLIM1,ITPR2,PREX2,PCDH9,NPAS3,TNIK,CDH20,TRPS1,GPM6A,NTRK2,CPE,RORA,NHSL1,MACF1,ATP13A4,GLUD1,NTM,NRXN1,NKAIN3,NFIA,SLC1A2,SOX5
5.157e-03	-5.27	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	8	16828	49	ATP1A2,TNIK,FGFR3,MACF1,ITPR2,PREX2,NTRK2,BMPR1B
5.198e-03	-5.26	RDX (radixin)	protein interactions	5962	272	4	19454	50	FGFR3,ABLIM1,NEBL,MACF1
5.198e-03	-5.26	PAS	prosite domains	PS50112	30	2	12186	44	HIF3A,NPAS3
5.251e-03	-5.25	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	3	16828	49	CDH20,DTNA,FGFR3
5.299e-03	-5.24	glutamate dehydrogenase (NADP+) activity	molecular function	GO:0004354	2	1	18094	48	GLUD1
5.299e-03	-5.24	glutamate dehydrogenase [NAD(P)+] activity	molecular function	GO:0004353	2	1	18094	48	GLUD1
5.299e-03	-5.24	glutamate dehydrogenase (NAD+) activity	molecular function	GO:0004352	2	1	18094	48	GLUD1
5.299e-03	-5.24	leukemia inhibitory factor receptor activity	molecular function	GO:0004923	2	1	18094	48	LIFR
5.299e-03	-5.24	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	molecular function	GO:0016639	2	1	18094	48	GLUD1
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	44	ATP1A2,ATP13A4
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	44	ATP13A4,ATP1A2
5.366e-03	-5.23	NFIB (nuclear factor I B)	protein interactions	4781	138	3	19454	50	TRPS1,NFIA,SOX5
5.377e-03	-5.23	somatodendritic compartment	cellular component	GO:0036477	842	7	19108	49	NTRK2,BMPR1B,GPM6A,ATP1A2,CTNND2,SLC1A3,NRXN1
5.386e-03	-5.22	membrane	cellular component	GO:0016020	9220	33	19108	49	HIF3A,PTGDS,CTNND2,SFXN5,CTNNA2,MACF1,NKAIN3,CPE,RYR3,SLC1A3,LSAMP,GPM6A,GPC5,SLC4A4,SLC1A2,PTPRZ1,CST3,PCDH9,CDH20,ATP1A2,PREX2,FGFR3,NTRK2,NRXN1,LIFR,PARD3B,ATP13A4,TNIK,ITPR2,DTNA,BMPR1B,NTM,FMN2
5.392e-03	-5.22	Glu/Leu/Phe/Val/Trp_DH_dimer	interpro domains	IPR006097	2	1	18521	50	GLUD1
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	Glu/Leu/Phe/Val/Trp_DH_C	interpro domains	IPR006096	2	1	18521	50	GLUD1
5.392e-03	-5.22	Par3/HAL_N	interpro domains	IPR021922	2	1	18521	50	PARD3B
5.392e-03	-5.22	Glu/Leu/Phe/Val/Trp_DH	interpro domains	IPR006095	2	1	18521	50	GLUD1
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	LIFR_D2	interpro domains	IPR040817	2	1	18521	50	LIFR
5.392e-03	-5.22	LIF-R-like_Ig-like	interpro domains	IPR048497	2	1	18521	50	LIFR
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	NAD_bind_Glu_DH	interpro domains	IPR033922	2	1	18521	50	GLUD1
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	Glu/Leu/Phe/Val_DH_AS	interpro domains	IPR033524	2	1	18521	50	GLUD1
5.440e-03	-5.21	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	2	19108	49	ITPR2,RYR3
5.486e-03	-5.21	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	50	CST3
5.486e-03	-5.21	fibroblast growth factor receptor apoptotic signaling pathway	biological process	GO:1902178	2	1	18204	50	FGFR3
5.486e-03	-5.21	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	50	CST3
5.492e-03	-5.20	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	4	18094	48	SLC1A3,SLC1A2,SFXN5,SLC4A4
5.517e-03	-5.20	Glutamatergic synapse	KEGG pathways	ko04724	114	3	7161	23	SLC1A3,ITPR2,SLC1A2
5.517e-03	-5.20	Glutamatergic synapse	KEGG pathways	hsa04724	114	3	7161	23	SLC1A3,ITPR2,SLC1A2
5.535e-03	-5.20	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	6	16828	49	FGFR3,TNIK,MAML2,LIFR,NTRK2,RYR3
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A3,SLC1A2
5.547e-03	-5.19	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	50	FGFR3,NTRK2,BMPR1B
5.612e-03	-5.18	LIF-R_Ig-like	pfam domains	PF21177	2	1	17795	50	LIFR
5.612e-03	-5.18	LIFR_D2	pfam domains	PF17971	2	1	17795	50	LIFR
5.612e-03	-5.18	ELFV_dehydrog_N	pfam domains	PF02812	2	1	17795	50	GLUD1
5.612e-03	-5.18	ELFV_dehydrog	pfam domains	PF00208	2	1	17795	50	GLUD1
5.612e-03	-5.18	Par3_HAL_N_term	pfam domains	PF12053	2	1	17795	50	PARD3B
5.612e-03	-5.18	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	48	GPM6A,ITPR2,RYR3
5.612e-03	-5.18	growth factor binding	molecular function	GO:0019838	136	3	18094	48	NTRK2,LIFR,FGFR3
5.692e-03	-5.17	actin binding	molecular function	GO:0003779	434	5	18094	48	NEBL,FMN2,ABLIM1,MACF1,CTNNA2
5.752e-03	-5.16	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	10	16828	49	RYR3,CPE,ATP13A4,PCDH9,ITPR2,MACF1,ATP1A2,PARD3B,CTNND2,FGFR3
5.755e-03	-5.16	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	47	16828	49	LIFR,SPARCL1,AHCYL2,PTGDS,FBXL7,BMPR1B,RYR3,DTNA,PITPNC1,SLC4A4,SFXN5,FGFR3,ATP1A2,PARD3B,LSAMP,GLIS3,HIF3A,ZBTB20,PTPRZ1,MAML2,FMN2,GPC5,CTNND2,SLC1A3,NEBL,MSI2,MACF1,NHSL1,GLUD1,ATP13A4,NRXN1,SLC1A2,SOX5,NFIA,NKAIN3,ITPR2,ABLIM1,NPAS3,PCDH9,PREX2,TRPS1,GPM6A,CDH20,TNIK,CPE,RORA,NTRK2
5.755e-03	-5.16	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	47	16828	49	SLC1A2,SOX5,NFIA,NKAIN3,NRXN1,GLUD1,ATP13A4,MACF1,NHSL1,CPE,RORA,NTRK2,CDH20,TRPS1,GPM6A,TNIK,PCDH9,PREX2,NPAS3,ITPR2,ABLIM1,BMPR1B,RYR3,DTNA,AHCYL2,FBXL7,PTGDS,LIFR,SPARCL1,NEBL,MSI2,PTPRZ1,SLC1A3,CTNND2,MAML2,FMN2,GPC5,HIF3A,LSAMP,GLIS3,ZBTB20,SFXN5,PITPNC1,SLC4A4,ATP1A2,PARD3B,FGFR3
5.767e-03	-5.16	sarcolemma	cellular component	GO:0042383	142	3	19108	49	RYR3,DTNA,ATP1A2
5.802e-03	-5.15	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	4	16828	49	NPAS3,GPC5,NFIA,PCDH9
5.802e-03	-5.15	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	4	16828	49	PCDH9,NFIA,GPC5,NPAS3
5.813e-03	-5.15	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	3	17795	50	BMPR1B,NTRK2,FGFR3
5.817e-03	-5.15	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	50	ITPR2,RYR3,ATP1A2
5.885e-03	-5.14	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	4	16828	49	MACF1,PTPRZ1,GLIS3,FGFR3
6.037e-03	-5.11	Calml3 (calmodulin-like 3)	protein interactions	70405	144	3	19454	50	MACF1,ZBTB20,ABLIM1
6.073e-03	-5.10	-	gene3d domains	6.20.350.10	2	1	14470	44	RYR3
6.073e-03	-5.10	-	gene3d domains	1.10.287.140	2	1	14470	44	GLUD1
6.073e-03	-5.10	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	44	CTNNA2
6.107e-03	-5.10	axon	cellular component	GO:0030424	650	6	19108	49	SLC1A2,NTRK2,PCDH9,DTNA,GPM6A,CTNNA2
6.237e-03	-5.08	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	5	18204	50	SLC4A4,ATP1A2,ATP13A4,RYR3,SLC1A3
6.257e-03	-5.07	active transmembrane transporter activity	molecular function	GO:0022804	444	5	18094	48	SLC4A4,SLC1A2,ATP13A4,ATP1A2,SLC1A3
6.372e-03	-5.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	39	16828	49	AHCYL2,NTM,ATP13A4,FBXL7,LIFR,MACF1,NHSL1,SPARCL1,SLC1A2,RYR3,SOX5,NKAIN3,NFIA,NRXN1,HIF3A,LSAMP,GLIS3,PCDH9,PREX2,NPAS3,SFXN5,ITPR2,SLC4A4,ATP1A2,PARD3B,ABLIM1,NEBL,CPE,RORA,MSI2,NTRK2,CDH20,PTPRZ1,CTNND2,SLC1A3,MAML2,GPC5,TNIK,FMN2
6.372e-03	-5.06	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	39	16828	49	ATP1A2,PARD3B,ABLIM1,SFXN5,ITPR2,SLC4A4,PCDH9,PREX2,NPAS3,HIF3A,GLIS3,LSAMP,CTNND2,SLC1A3,TNIK,GPC5,MAML2,FMN2,CDH20,PTPRZ1,MSI2,NTRK2,NEBL,CPE,RORA,NHSL1,SPARCL1,LIFR,MACF1,ATP13A4,FBXL7,AHCYL2,NTM,NRXN1,NKAIN3,NFIA,SLC1A2,RYR3,SOX5
6.384e-03	-5.05	parotid	COSMIC cancer mutations	parotid	578	6	16828	49	NTRK2,RYR3,FGFR3,TNIK,MAML2,LIFR
6.420e-03	-5.05	trans-synaptic signaling	biological process	GO:0099537	431	5	18204	50	NRXN1,NTRK2,DTNA,SLC1A2,SLC1A3
6.429e-03	-5.05	extremity	COSMIC cancer mutations	extremity	1876	12	16828	49	FMN2,FGFR3,CDH20,PTPRZ1,PITPNC1,PCDH9,ATP13A4,FBXL7,PREX2,NTRK2,RYR3,NEBL
6.500e-03	-5.04	CNTN1 (contactin 1)	protein interactions	1272	47	2	19454	50	PTPRZ1,GPM6A
6.500e-03	-5.04	BDNF (brain derived neurotrophic factor)	protein interactions	627	47	2	19454	50	CPE,NTRK2
6.550e-03	-5.03	PAS domain	gene3d domains	3.30.450.20	40	2	14470	44	HIF3A,NPAS3
6.597e-03	-5.02	upper_arm	COSMIC cancer mutations	upper_arm	582	6	16828	49	PREX2,SLC4A4,ITPR2,PARD3B,FGFR3,FMN2
6.634e-03	-5.02	GSE1 (Gse1 coiled-coil protein)	protein interactions	23199	149	3	19454	50	NFIA,SOX5,TNIK
6.634e-03	-5.02	vascular process in circulatory system	biological process	GO:0003018	273	4	18204	50	SLC1A3,SLC1A2,ATP1A2,SLC4A4
6.660e-03	-5.01	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	4	16828	49	ATP13A4,FMN2,SLC4A4,PTPRZ1
6.676e-03	-5.01	inorganic cation transmembrane transport	biological process	GO:0098662	618	6	18204	50	ATP1A2,SLC4A4,RYR3,SLC1A3,GPM6A,ITPR2
6.798e-03	-4.99	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	5	18204	50	ATP1A2,ATP13A4,RYR3,SLC1A3,SLC4A4
6.853e-03	-4.98	cell-cell signaling	biological process	GO:0007267	822	7	18204	50	NRXN1,SLC1A3,SLC1A2,DTNA,FGFR3,CPE,NTRK2
6.870e-03	-4.98	uveal_tract	COSMIC cancer mutations	uveal_tract	587	6	16828	49	MACF1,CPE,FGFR3,PREX2,CTNND2,PCDH9
6.875e-03	-4.98	transmembrane transport	biological process	GO:0055085	1264	9	18204	50	SFXN5,ATP1A2,SLC4A4,ATP13A4,SLC1A3,SLC1A2,RYR3,ITPR2,GPM6A
6.890e-03	-4.98	learning or memory	biological process	GO:0007611	276	4	18204	50	NTRK2,ATP1A2,PTPRZ1,NRXN1
6.939e-03	-4.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	8	16828	49	ITPR2,GPC5,CTNND2,RORA,LSAMP,SOX5,NKAIN3,PCDH9
6.969e-03	-4.97	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	50	SLC1A2,SLC1A3,SLC4A4
7.064e-03	-4.95	SP7 (Sp7 transcription factor)	protein interactions	121340	297	4	19454	50	SOX5,NFIA,GLUD1,TRPS1
7.087e-03	-4.95	symporter activity	molecular function	GO:0015293	148	3	18094	48	SLC4A4,SLC1A2,SLC1A3
7.135e-03	-4.94	SOX6 (SRY-box transcription factor 6)	protein interactions	55553	153	3	19454	50	NFIA,SOX5,TRPS1
7.203e-03	-4.93	SFN (stratifin)	protein interactions	2810	671	6	19454	50	FMN2,PARD3B,MACF1,ABLIM1,NFIA,TNIK
7.209e-03	-4.93	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	44	SPARCL1
7.209e-03	-4.93	GLFV_DEHYDROGENASE	prosite domains	PS00074	2	1	12186	44	GLUD1
7.209e-03	-4.93	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	44	SPARCL1
7.240e-03	-4.93	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	29	ATP1A2,ITPR2,RYR3
7.272e-03	-4.92	Ig_3	pfam domains	PF13927	141	3	17795	50	FGFR3,LSAMP,NTM
7.312e-03	-4.92	metal ion transport	biological process	GO:0030001	630	6	18204	50	SLC4A4,ATP1A2,ITPR2,GPM6A,RYR3,SLC1A3
7.404e-03	-4.91	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	4	16828	49	LIFR,SOX5,RYR3,CDH20
7.426e-03	-4.90	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	44	ATP1A2,ATP13A4
7.456e-03	-4.90	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	9	16828	49	CTNND2,TNIK,GPC5,ITPR2,PCDH9,NKAIN3,SOX5,LSAMP,RORA
7.515e-03	-4.89	Wnt signaling pathway	biological process	GO:0016055	283	4	18204	50	CPE,TNIK,MACF1,CTNND2
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	MACF1,NHSL1
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Hk2 (hexokinase 2)	protein interactions	25059	3	1	19454	50	PTGDS
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	50	NRXN1
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.702e-03	-4.87	animal organ development	biological process	GO:0048513	2846	15	18204	50	GLUD1,CPE,ATP1A2,RORA,PCDH9,GPM6A,BMPR1B,SOX5,NTRK2,NEBL,FGFR3,ABLIM1,SLC1A2,NFIA,CTNNA2
7.761e-03	-4.86	C20 prostanoid biosynthesis	BIOCYC pathways	META_PWY66-374	7	1	902	1	PTGDS
7.761e-03	-4.86	C20 prostanoid biosynthesis	BIOCYC pathways	HUMAN_PWY66-374	7	1	902	1	PTGDS
7.762e-03	-4.86	anchoring junction	cellular component	GO:0070161	902	7	19108	49	CTNND2,CDH20,ATP1A2,PARD3B,PCDH9,CTNNA2,FGFR3
7.832e-03	-4.85	response to organic cyclic compound	biological process	GO:0014070	843	7	18204	50	ATP1A2,RORA,SLC1A2,RYR3,SLC1A3,PTGDS,ITPR2
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.938e-03	-4.84	adenosylhomocysteinase activity	molecular function	GO:0004013	3	1	18094	48	AHCYL2
7.938e-03	-4.84	inositol 1,4,5-trisphosphate-gated calcium channel activity	molecular function	GO:0005220	3	1	18094	48	ITPR2
7.938e-03	-4.84	oncostatin-M receptor activity	molecular function	GO:0004924	3	1	18094	48	LIFR
7.938e-03	-4.84	prostaglandin-D synthase activity	molecular function	GO:0004667	3	1	18094	48	PTGDS
7.938e-03	-4.84	hydrolase activity, acting on carbon-sulfur bonds	molecular function	GO:0046508	3	1	18094	48	AHCYL2
7.952e-03	-4.83	neuromuscular process	biological process	GO:0050905	149	3	18204	50	SLC1A3,NRXN1,CTNNA2
7.984e-03	-4.83	eye	COSMIC cancer mutations	eye	606	6	16828	49	CPE,PREX2,PCDH9,MACF1,FGFR3,CTNND2
8.065e-03	-4.82	SOX5 (SRY-box transcription factor 5)	protein interactions	6660	160	3	19454	50	SOX5,NFIA,TRPS1
8.078e-03	-4.82	Ado_hCys_hydrolase_NAD-bd	interpro domains	IPR015878	3	1	18521	50	AHCYL2
8.078e-03	-4.82	Adenosylhomocysteinase-like	interpro domains	IPR000043	3	1	18521	50	AHCYL2
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	InsP3_rcpt	interpro domains	IPR000493	3	1	18521	50	ITPR2
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	50	HIF3A
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	S-Ado-L-homoCys_hydrolase_CS	interpro domains	IPR020082	3	1	18521	50	AHCYL2
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	MAML1-3	interpro domains	IPR046369	3	1	18521	50	MAML2
8.078e-03	-4.82	Mastermind-like_N	interpro domains	IPR019082	3	1	18521	50	MAML2
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	Adenosylhomocyst_ase-like_sf	interpro domains	IPR042172	3	1	18521	50	AHCYL2
8.078e-03	-4.82	MAML_N_sf	interpro domains	IPR046370	3	1	18521	50	MAML2
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.085e-03	-4.82	signaling	biological process	GO:0023052	4968	22	18204	50	TNIK,SLC1A2,FGFR3,BMPR1B,NTRK2,NRXN1,LIFR,RYR3,SLC1A3,PREX2,FMN2,ATP1A2,CPE,NFIA,PITPNC1,DTNA,CTNND2,SPARCL1,ITPR2,MAML2,RORA,MACF1
8.088e-03	-4.82	amino acid binding	molecular function	GO:0016597	51	2	18094	48	GLUD1,SLC1A3
8.136e-03	-4.81	SLC-mediated transmembrane transport	REACTOME pathways	R-HSA-425407	287	4	10285	29	SLC1A3,AHCYL2,SLC1A2,SLC4A4
8.206e-03	-4.80	FOXF2 (forkhead box F2)	protein interactions	2295	53	2	19454	50	ZBTB20,AHCYL2
8.216e-03	-4.80	ELFV_dehydrog	smart domains	SM00839	2	1	9717	40	GLUD1
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.218e-03	-4.80	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	50	FMN2
8.218e-03	-4.80	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	50	NTRK2
8.218e-03	-4.80	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	50	NRXN1
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.218e-03	-4.80	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	50	NEBL
8.218e-03	-4.80	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	50	FMN2
8.218e-03	-4.80	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	50	FMN2
8.218e-03	-4.80	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	50	CTNNA2
8.317e-03	-4.79	synaptic signaling	biological process	GO:0099536	459	5	18204	50	NRXN1,NTRK2,DTNA,SLC1A2,SLC1A3
8.406e-03	-4.78	RYDR_Jsol	pfam domains	PF21119	3	1	17795	50	RYR3
8.406e-03	-4.78	LRRCT_2	pfam domains	PF16920	3	1	17795	50	NTRK2
8.406e-03	-4.78	Myelin_PLP	pfam domains	PF01275	3	1	17795	50	GPM6A
8.406e-03	-4.78	SR_plectin_7	pfam domains	PF21097	3	1	17795	50	MACF1
8.406e-03	-4.78	AdoHcyase	pfam domains	PF05221	3	1	17795	50	AHCYL2
8.406e-03	-4.78	HIF-1	pfam domains	PF11413	3	1	17795	50	HIF3A
8.406e-03	-4.78	RR_TM4-6	pfam domains	PF06459	3	1	17795	50	RYR3
8.406e-03	-4.78	RyR	pfam domains	PF02026	3	1	17795	50	RYR3
8.406e-03	-4.78	MamL-1	pfam domains	PF09596	3	1	17795	50	MAML2
8.406e-03	-4.78	AdoHcyase_NAD	pfam domains	PF00670	3	1	17795	50	AHCYL2
8.436e-03	-4.78	protein binding	molecular function	GO:0005515	13983	44	18094	48	PITPNC1,MSI2,SLC1A2,GLIS3,NTRK2,SOX5,GPC5,GLUD1,CPE,CDH20,LSAMP,TNIK,FGFR3,MAML2,FBXL7,RORA,PTPRZ1,BMPR1B,HIF3A,ATP1A2,ITPR2,PARD3B,RYR3,NRXN1,GPM6A,NPAS3,SLC1A3,ABLIM1,LIFR,NTM,SLC4A4,SFXN5,FMN2,SPARCL1,DTNA,CTNND2,CTNNA2,NFIA,PTGDS,AHCYL2,MACF1,TRPS1,CST3,NEBL
8.507e-03	-4.77	TAFA4 (TAFA chemokine like family member 4)	protein interactions	151647	54	2	19454	50	LIFR,ITPR2
8.546e-03	-4.76	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	13	16828	49	TNIK,TRPS1,PTPRZ1,NTRK2,NFIA,DTNA,BMPR1B,SOX5,FGFR3,ATP1A2,PARD3B,SLC4A4,PREX2
8.651e-03	-4.75	neuromuscular process controlling balance	biological process	GO:0050885	51	2	18204	50	NRXN1,SLC1A3
8.702e-03	-4.74	learning	biological process	GO:0007612	154	3	18204	50	NRXN1,ATP1A2,NTRK2
8.702e-03	-4.74	calcium-mediated signaling	biological process	GO:0019722	154	3	18204	50	ITPR2,ATP1A2,RYR3
8.711e-03	-4.74	urinary_tract-bladder-papilloma	COSMIC cancer mutations	urinary_tract-bladder-papilloma	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-leg-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-lentigo	COSMIC cancer mutations	skin-trunk-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-lentigo	COSMIC cancer mutations	skin-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-face-lentigo	COSMIC cancer mutations	skin-face-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-forearm-lentigo	COSMIC cancer mutations	skin-forearm-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-trunk-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-hand-lentigo	COSMIC cancer mutations	skin-hand-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-lentigo	COSMIC cancer mutations	skin-leg-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	lentigo	COSMIC cancer mutations	lentigo	3	1	16828	49	FGFR3
8.712e-03	-4.74	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	48	ATP13A4,ATP1A2
8.736e-03	-4.74	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	20	CST3,SLC1A2
8.771e-03	-4.74	EGR2 (early growth response 2)	protein interactions	1959	165	3	19454	50	NFIA,SOX5,TRPS1
8.771e-03	-4.74	positive regulation of nervous system development	biological process	GO:0051962	296	4	18204	50	NTRK2,MACF1,PTPRZ1,NRXN1
8.782e-03	-4.74	FORMIN	prints domains	PR00828	2	1	5227	23	FMN2
8.782e-03	-4.74	GLFDHDRGNASE	prints domains	PR00082	2	1	5227	23	GLUD1
8.873e-03	-4.72	carboxylic acid transport	biological process	GO:0046942	297	4	18204	50	SFXN5,NTRK2,SLC1A3,SLC1A2
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	ATP1A2,NEBL,ABLIM1
8.976e-03	-4.71	organic acid transport	biological process	GO:0015849	298	4	18204	50	SLC1A2,SLC1A3,NTRK2,SFXN5
8.978e-03	-4.71	cell communication	biological process	GO:0007154	5010	22	18204	50	BMPR1B,NTRK2,FGFR3,SLC1A2,TNIK,CPE,ATP1A2,PREX2,FMN2,RYR3,SLC1A3,NRXN1,LIFR,SPARCL1,CTNND2,DTNA,NFIA,PITPNC1,MACF1,MAML2,RORA,ITPR2
8.982e-03	-4.71	regulation of purine nucleotide catabolic process	biological process	GO:0033121	52	2	18204	50	ZBTB20,SLC4A4
8.982e-03	-4.71	regulation of glycolytic process	biological process	GO:0006110	52	2	18204	50	ZBTB20,SLC4A4
8.982e-03	-4.71	regulation of nucleotide catabolic process	biological process	GO:0030811	52	2	18204	50	SLC4A4,ZBTB20
8.986e-03	-4.71	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	29	SLC1A3,SLC1A2
9.015e-03	-4.71	calcium ion binding	molecular function	GO:0005509	683	6	18094	48	RYR3,PCDH9,NRXN1,ITPR2,SPARCL1,MACF1
9.095e-03	-4.70	Adenosylhomocysteinase-like	gene3d domains	3.40.50.1480	3	1	14470	44	AHCYL2
9.095e-03	-4.70	-	gene3d domains	6.10.250.970	3	1	14470	44	MAML2
9.095e-03	-4.70	-	gene3d domains	1.10.490.160	3	1	14470	44	RYR3
9.095e-03	-4.70	-	gene3d domains	6.10.250.2510	3	1	14470	44	CTNNA2
9.147e-03	-4.69	presynaptic membrane	cellular component	GO:0042734	168	3	19108	49	SLC1A2,NRXN1,GPM6A
9.171e-03	-4.69	positive regulation of synaptic transmission	biological process	GO:0050806	157	3	18204	50	NRXN1,NTRK2,SLC1A3
9.191e-03	-4.69	EF-hand	gene3d domains	1.10.238.10	272	4	14470	44	DTNA,MACF1,SPARCL1,RYR3
9.212e-03	-4.69	POU2F1 (POU class 2 homeobox 1)	protein interactions	5451	168	3	19454	50	SOX5,GPC5,LIFR
9.318e-03	-4.68	neutral amino acid transport	biological process	GO:0015804	53	2	18204	50	SLC1A3,SLC1A2
9.442e-03	-4.66	NXPH3 (neurexophilin 3)	protein interactions	11248	57	2	19454	50	CTNNA2,NRXN1
9.492e-03	-4.66	monoatomic anion transport	biological process	GO:0006820	159	3	18204	50	SLC1A2,SLC1A3,SLC4A4
9.538e-03	-4.65	Signaling pathways regulating pluripotency of stem cells	KEGG pathways	hsa04550	139	3	7161	23	BMPR1B,LIFR,FGFR3
9.538e-03	-4.65	Signaling pathways regulating pluripotency of stem cells	KEGG pathways	ko04550	139	3	7161	23	BMPR1B,LIFR,FGFR3
9.616e-03	-4.64	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	48	16828	49	NEBL,MSI2,PTPRZ1,FMN2,GPC5,MAML2,CTNND2,SLC1A3,GLIS3,LSAMP,HIF3A,ZBTB20,SLC4A4,PITPNC1,SFXN5,FGFR3,PARD3B,ATP1A2,RYR3,BMPR1B,DTNA,AHCYL2,PTGDS,FBXL7,LIFR,SPARCL1,RORA,CPE,NTRK2,GPM6A,TRPS1,CDH20,TNIK,NPAS3,PCDH9,PREX2,ITPR2,ABLIM1,SOX5,SLC1A2,NFIA,NKAIN3,NRXN1,NTM,GLUD1,ATP13A4,MACF1,NHSL1
9.634e-03	-4.64	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	49	16828	49	MSI2,NEBL,CTNND2,SLC1A3,MAML2,FMN2,GPC5,PTPRZ1,CST3,ZBTB20,HIF3A,LSAMP,GLIS3,PARD3B,ATP1A2,FGFR3,SFXN5,SLC4A4,PITPNC1,DTNA,RYR3,BMPR1B,FBXL7,PTGDS,AHCYL2,SPARCL1,LIFR,NTRK2,RORA,CPE,TNIK,CDH20,GPM6A,TRPS1,PREX2,PCDH9,NPAS3,ABLIM1,ITPR2,NKAIN3,NFIA,SOX5,SLC1A2,NRXN1,ATP13A4,GLUD1,NTM,NHSL1,MACF1
9.709e-03	-4.63	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	11	19454	50	DTNA,ZBTB20,ABLIM1,AHCYL2,BMPR1B,PARD3B,MACF1,TRPS1,NFIA,FGFR3,MSI2
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	ATP1A2,NTRK2,GPM6A
9.858e-03	-4.62	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	6	16828	49	NFIA,FMN2,PREX2,PTPRZ1,NTM,NEBL
9.950e-03	-4.61	CAV1 (caveolin 1)	protein interactions	857	719	6	19454	50	TNIK,DTNA,AHCYL2,MACF1,FMN2,SLC1A3
1.001e-02	-4.60	response to cocaine	biological process	GO:0042220	55	2	18204	50	SLC1A2,SLC1A3
1.002e-02	-4.60	Znf_NHR/GATA	interpro domains	IPR013088	56	2	18521	50	RORA,TRPS1
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	ATP1A2,NTRK2,GPM6A
1.009e-02	-4.60	CATATPASE	prints domains	PR00119	35	2	5227	23	ATP13A4,ATP1A2
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	CDH20,DTNA,CTNNA2
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.029e-02	-4.58	LHX3 (LIM homeobox 3)	protein interactions	8022	175	3	19454	50	SOX5,NFIA,TRPS1
1.036e-02	-4.57	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	50	RYR3,ITPR2
1.042e-02	-4.56	SNTB1 (syntrophin beta 1)	protein interactions	6641	60	2	19454	50	FGFR3,DTNA
1.043e-02	-4.56	actin cytoskeleton	cellular component	GO:0015629	520	5	19108	49	FMN2,MACF1,CTNNA2,ABLIM1,NEBL
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	SLC1A2,SLC1A3,ATP1A2
1.057e-02	-4.55	ciliary neurotrophic factor receptor activity	molecular function	GO:0004897	4	1	18094	48	LIFR
1.057e-02	-4.55	citrate transmembrane transporter activity	molecular function	GO:0015137	4	1	18094	48	SFXN5
1.057e-02	-4.55	tricarboxylic acid transmembrane transporter activity	molecular function	GO:0015142	4	1	18094	48	SFXN5
1.057e-02	-4.55	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	48	NTRK2
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.072e-02	-4.54	visual behavior	biological process	GO:0007632	57	2	18204	50	SLC1A2,ATP1A2
1.072e-02	-4.54	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	50	ITPR2,RYR3
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	FGF_rcpt_fam	interpro domains	IPR016248	4	1	18521	50	FGFR3
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.079e-02	-4.53	ADOHCYASE_1	prosite domains	PS00738	3	1	12186	44	AHCYL2
1.079e-02	-4.53	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	44	GPM6A
1.079e-02	-4.53	ADOHCYASE_2	prosite domains	PS00739	3	1	12186	44	AHCYL2
1.079e-02	-4.53	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	44	GPM6A
1.079e-02	-4.53	VINCULIN_1	prosite domains	PS00663	3	1	12186	44	CTNNA2
1.090e-02	-4.52	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	6	16828	49	FGFR3,TNIK,NTRK2,PREX2,TRPS1,BMPR1B
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.094e-02	-4.52	negative regulation of germ cell proliferation	biological process	GO:1905937	4	1	18204	50	PTGDS
1.094e-02	-4.52	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	50	NTRK2
1.094e-02	-4.52	oncostatin-M-mediated signaling pathway	biological process	GO:0038165	4	1	18204	50	LIFR
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.094e-02	-4.52	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	50	BMPR1B
1.094e-02	-4.52	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	50	CST3
1.094e-02	-4.52	protein localization to secretory granule	biological process	GO:0033366	4	1	18204	50	CPE
1.094e-02	-4.52	leukemia inhibitory factor signaling pathway	biological process	GO:0048861	4	1	18204	50	LIFR
1.094e-02	-4.52	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	50	NTRK2
1.094e-02	-4.52	glutamate biosynthetic process	biological process	GO:0006537	4	1	18204	50	GLUD1
1.094e-02	-4.52	negative regulation of male germ cell proliferation	biological process	GO:2000255	4	1	18204	50	PTGDS
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	DTNA,RYR3,BMPR1B,SPARCL1,LIFR,FBXL7,PTGDS,AHCYL2,SLC1A3,CTNND2,MAML2,GPC5,FMN2,PTPRZ1,MSI2,NEBL,PARD3B,ATP1A2,FGFR3,SFXN5,SLC4A4,PITPNC1,ZBTB20,CST3,HIF3A,LSAMP,GLIS3,NRXN1,NFIA,NKAIN3,SOX5,SLC1A2,NHSL1,MACF1,ATP13A4,GLUD1,NTM,TNIK,CDH20,GPM6A,TRPS1,NTRK2,RORA,CPE,ABLIM1,ITPR2,PCDH9,PREX2,NPAS3
1.110e-02	-4.50	cellular homeostasis	biological process	GO:0019725	689	6	18204	50	ATP13A4,RYR3,SLC1A3,ZBTB20,ATP1A2,SLC4A4
1.110e-02	-4.50	MYOD1 (myogenic differentiation 1)	protein interactions	4654	180	3	19454	50	TRPS1,RORA,NFIA
1.110e-02	-4.50	EPHA4 (EPH receptor A4)	protein interactions	2043	180	3	19454	50	FGFR3,AHCYL2,CTNNA2
1.118e-02	-4.49	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	49	GPC5,MACF1,TRPS1,RYR3
1.119e-02	-4.49	P5-ATPase	pfam domains	PF12409	4	1	17795	50	ATP13A4
1.119e-02	-4.49	NKAIN	pfam domains	PF05640	4	1	17795	50	NKAIN3
1.119e-02	-4.49	CTF_NFI	pfam domains	PF00859	4	1	17795	50	NFIA
1.119e-02	-4.49	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	50	NFIA
1.119e-02	-4.49	Spectrin_2	pfam domains	PF18373	4	1	17795	50	MACF1
1.119e-02	-4.49	Spectrin_4	pfam domains	PF21020	4	1	17795	50	MACF1
1.119e-02	-4.49	AbLIM_anchor	pfam domains	PF16182	4	1	17795	50	ABLIM1
1.119e-02	-4.49	NHS	pfam domains	PF15273	4	1	17795	50	NHSL1
1.119e-02	-4.49	Nebulin	pfam domains	PF00880	4	1	17795	50	NEBL
1.119e-02	-4.49	Spectrin_3	pfam domains	PF21019	4	1	17795	50	MACF1
1.120e-02	-4.49	cellular response to growth factor stimulus	biological process	GO:0071363	494	5	18204	50	FGFR3,NFIA,NTRK2,SOX5,BMPR1B
1.132e-02	-4.48	cognition	biological process	GO:0050890	319	4	18204	50	NRXN1,PTPRZ1,NTRK2,ATP1A2
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.145e-02	-4.47	endochondral bone morphogenesis	biological process	GO:0060350	59	2	18204	50	FGFR3,BMPR1B
1.151e-02	-4.46	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	29	ATP13A4,ATP1A2
1.156e-02	-4.46	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	4	16828	49	FGFR3,GLIS3,PTPRZ1,MACF1
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.160e-02	-4.46	urinary_tract-bladder-papilloma-inverted	COSMIC cancer mutations	urinary_tract-bladder-papilloma-inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	inverted	COSMIC cancer mutations	inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.160e-02	-4.46	skin-benign_melanocytic_nevus-junctional	COSMIC cancer mutations	skin-benign_melanocytic_nevus-junctional	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-other-normal	COSMIC cancer mutations	urinary_tract-bladder-other-normal	4	1	16828	49	FGFR3
1.166e-02	-4.45	ion binding	molecular function	GO:0043167	6007	24	18094	48	CPE,GLUD1,SLC1A2,ABLIM1,PITPNC1,SLC1A3,NTRK2,GLIS3,TRPS1,MACF1,ZBTB20,ITPR2,ATP1A2,NRXN1,RYR3,PCDH9,ATP13A4,FGFR3,DTNA,TNIK,SPARCL1,RORA,BMPR1B,PTGDS
1.167e-02	-4.45	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	162	3	16828	49	RYR3,ITPR2,MACF1
1.175e-02	-4.44	skeletal system development	biological process	GO:0001501	500	5	18204	50	NFIA,FGFR3,TRPS1,BMPR1B,SOX5
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	FGFR3,NTRK2
1.178e-02	-4.44	cation binding	molecular function	GO:0043169	4341	19	18094	48	ATP13A4,SLC1A2,ABLIM1,SLC1A3,DTNA,SPARCL1,BMPR1B,RORA,GLIS3,CPE,TRPS1,ZBTB20,GLUD1,MACF1,ITPR2,ATP1A2,NRXN1,RYR3,PCDH9
1.179e-02	-4.44	EVA1C (eva-1 homolog C)	protein interactions	59271	64	2	19454	50	PCDH9,BMPR1B
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	NFIA,TRPS1
1.179e-02	-4.44	SYNC (syncoilin, intermediate filament protein)	protein interactions	81493	64	2	19454	50	MAML2,DTNA
1.182e-02	-4.44	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	50	NTRK2,ATP1A2
1.182e-02	-4.44	export across plasma membrane	biological process	GO:0140115	60	2	18204	50	ATP1A2,SLC4A4
1.184e-02	-4.44	cadherin binding	molecular function	GO:0045296	335	4	18094	48	MACF1,CTNNA2,CTNND2,CDH20
1.184e-02	-4.44	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	27	16828	49	PREX2,NPAS3,ZBTB20,HIF3A,PARD3B,FGFR3,ABLIM1,SFXN5,PITPNC1,SLC4A4,RORA,SLC1A3,CTNND2,FMN2,GPC5,MAML2,CDH20,TRPS1,GPM6A,FBXL7,NTM,NHSL1,LIFR,MACF1,SLC1A2,RYR3,SOX5
1.192e-02	-4.43	chemical homeostasis	biological process	GO:0048878	914	7	18204	50	ZBTB20,RORA,ATP13A4,SLC1A3,RYR3,SLC4A4,ATP1A2
1.211e-02	-4.41	-	gene3d domains	1.20.58.1060	4	1	14470	44	MACF1
1.216e-02	-4.41	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	49	RYR3,GPM6A,MACF1,TRPS1,GPC5
1.221e-02	-4.41	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	7	16828	49	TNIK,FGFR3,TRPS1,MACF1,PREX2,NTRK2,BMPR1B
1.223e-02	-4.40	monoatomic cation homeostasis	biological process	GO:0055080	505	5	18204	50	ATP13A4,ATP1A2,RYR3,SLC1A3,SLC4A4
1.228e-02	-4.40	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	6	16828	49	SPARCL1,FGFR3,NTRK2,TNIK,BMPR1B,LIFR
1.230e-02	-4.40	MamL-1	smart domains	SM01275	3	1	9717	40	MAML2
1.230e-02	-4.40	AdoHcyase_NAD	smart domains	SM00997	3	1	9717	40	AHCYL2
1.230e-02	-4.40	AdoHcyase	smart domains	SM00996	3	1	9717	40	AHCYL2
1.230e-02	-4.40	PLP	smart domains	SM00002	3	1	9717	40	GPM6A
1.248e-02	-4.38	HNF1B (HNF1 homeobox B)	protein interactions	6928	188	3	19454	50	TRPS1,NFIA,SOX5
1.249e-02	-4.38	central nervous system neuron differentiation	biological process	GO:0021953	176	3	18204	50	BMPR1B,NTRK2,RORA
1.249e-02	-4.38	back	COSMIC cancer mutations	back	310	4	16828	49	PREX2,ATP1A2,FGFR3,TNIK
1.250e-02	-4.38	ORM1 (orosomucoid 1)	protein interactions	5004	66	2	19454	50	PTGDS,GLUD1
1.250e-02	-4.38	MAML1 (mastermind like transcriptional coactivator 1)	protein interactions	9794	66	2	19454	50	MAML2,NFIA
1.254e-02	-4.38	Erythroid Transcription Factor GATA-1, subunit A	gene3d domains	3.30.50.10	56	2	14470	44	RORA,TRPS1
1.259e-02	-4.38	regulation of carbohydrate catabolic process	biological process	GO:0043470	62	2	18204	50	SLC4A4,ZBTB20
1.261e-02	-4.37	CDH1 (cadherin 1)	protein interactions	999	757	6	19454	50	ABLIM1,NEBL,NHSL1,CTNND2,CTNNA2,MACF1
1.262e-02	-4.37	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	6	16828	49	SPARCL1,NTRK2,FGFR3,TNIK,LIFR,BMPR1B
1.262e-02	-4.37	Ig-like_fold	interpro domains	IPR013783	721	6	18521	50	LIFR,NTM,LSAMP,FGFR3,PTPRZ1,NTRK2
1.266e-02	-4.37	peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	peripheral_T_cell_lymphoma_unspecified	167	3	16828	49	RYR3,ITPR2,MACF1
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	PTGER2 (prostaglandin E receptor 2)	protein interactions	5732	5	1	19454	50	PTGDS
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	TRH (thyrotropin releasing hormone)	protein interactions	7200	5	1	19454	50	CPE
1.279e-02	-4.36	ARSI (arylsulfatase family member I)	protein interactions	340075	5	1	19454	50	AHCYL2
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Hk3 (hexokinase 3)	protein interactions	25060	5	1	19454	50	PTGDS
1.279e-02	-4.36	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	50	NRXN1
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	D-Glutamine and D-glutamate metabolism	KEGG pathways	hsa00471	4	1	7161	23	GLUD1
1.279e-02	-4.36	D-Glutamine and D-glutamate metabolism	KEGG pathways	ko00471	4	1	7161	23	GLUD1
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	MACF1,NHSL1,NTM,GLUD1,ATP13A4,NRXN1,SOX5,SLC1A2,NKAIN3,NFIA,ITPR2,ABLIM1,NPAS3,PCDH9,PREX2,GPM6A,TRPS1,CDH20,TNIK,RORA,CPE,NTRK2,LIFR,SPARCL1,AHCYL2,PTGDS,FBXL7,RYR3,BMPR1B,SLC4A4,PITPNC1,SFXN5,FGFR3,PARD3B,ATP1A2,LSAMP,GLIS3,HIF3A,CST3,ZBTB20,PTPRZ1,FMN2,GPC5,MAML2,SLC1A3,CTNND2,NEBL,MSI2
1.310e-02	-4.34	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	5	16828	49	ATP13A4,PCDH9,SLC4A4,LSAMP,RYR3
1.310e-02	-4.34	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	5	16828	49	PCDH9,ATP13A4,RYR3,SLC4A4,LSAMP
1.314e-02	-4.33	inorganic ion transmembrane transport	biological process	GO:0098660	715	6	18204	50	RYR3,SLC1A3,GPM6A,ITPR2,ATP1A2,SLC4A4
1.315e-02	-4.33	MYELINPLP	prints domains	PR00214	3	1	5227	23	GPM6A
1.315e-02	-4.33	NTKRECEPTOR	prints domains	PR01939	3	1	5227	23	NTRK2
1.315e-02	-4.33	PGNDSYNTHASE	prints domains	PR01254	3	1	5227	23	PTGDS
1.315e-02	-4.33	INSP3RECEPTR	prints domains	PR00779	3	1	5227	23	ITPR2
1.315e-02	-4.33	RORNUCRECPTR	prints domains	PR01293	3	1	5227	23	RORA
1.315e-02	-4.33	RYANODINER	prints domains	PR00795	3	1	5227	23	RYR3
1.317e-02	-4.33	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	3	18094	48	SFXN5,SLC1A2,SLC1A3
1.317e-02	-4.33	upper_leg	COSMIC cancer mutations	upper_leg	880	7	16828	49	FGFR3,FMN2,HIF3A,GLIS3,PCDH9,PREX2,NFIA
1.320e-02	-4.33	fibroblast growth factor receptor activity	molecular function	GO:0005007	5	1	18094	48	FGFR3
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.320e-02	-4.33	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	48	NTRK2
1.320e-02	-4.33	neuroligin family protein binding	molecular function	GO:0097109	5	1	18094	48	NRXN1
1.321e-02	-4.33	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	23	16828	49	SPARCL1,LIFR,FBXL7,ATP13A4,BMPR1B,SOX5,FGFR3,ABLIM1,PITPNC1,ITPR2,PREX2,NPAS3,HIF3A,LSAMP,CTNND2,SLC1A3,MAML2,TNIK,TRPS1,PTPRZ1,MSI2,NTRK2,RORA
1.321e-02	-4.33	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	23	16828	49	MSI2,NTRK2,SOX5,BMPR1B,RORA,CTNND2,SLC1A3,TNIK,MAML2,PTPRZ1,TRPS1,ATP13A4,PREX2,FBXL7,NPAS3,HIF3A,LSAMP,ABLIM1,SPARCL1,FGFR3,ITPR2,PITPNC1,LIFR
1.322e-02	-4.33	monoatomic ion homeostasis	biological process	GO:0050801	515	5	18204	50	SLC1A3,RYR3,ATP1A2,ATP13A4,SLC4A4
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A2,SLC1A3
1.332e-02	-4.32	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	5	16828	49	BMPR1B,MACF1,FGFR3,NTRK2,TNIK
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.332e-02	-4.32	human chr13q21.32	chromosome location	human chr13q21.32	7	1	26134	50	PCDH9
1.335e-02	-4.32	camera-type eye development	biological process	GO:0043010	335	4	18204	50	NTRK2,BMPR1B,GPM6A,NFIA
1.336e-02	-4.32	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	3	18094	48	SFXN5,SLC1A2,SLC1A3
1.343e-02	-4.31	Protocadherin	interpro domains	IPR013585	5	1	18521	50	PCDH9
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	Mtc	interpro domains	IPR004686	5	1	18521	50	SFXN5
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.356e-02	-4.30	arm	COSMIC cancer mutations	arm	1331	9	16828	49	MACF1,SLC4A4,TRPS1,PARD3B,ATP1A2,FGFR3,NTM,ZBTB20,NPAS3
1.366e-02	-4.29	citrate transport	biological process	GO:0015746	5	1	18204	50	SFXN5
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	50	NTRK2
1.366e-02	-4.29	tricarboxylic acid transport	biological process	GO:0006842	5	1	18204	50	SFXN5
1.366e-02	-4.29	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	50	FMN2
1.366e-02	-4.29	ciliary neurotrophic factor-mediated signaling pathway	biological process	GO:0070120	5	1	18204	50	LIFR
1.366e-02	-4.29	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	50	BMPR1B
1.366e-02	-4.29	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	50	NRXN1
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	LIFR,MACF1,NHSL1,SPARCL1,GLUD1,AHCYL2,NTM,FBXL7,ATP13A4,PTGDS,NRXN1,SLC1A2,BMPR1B,SOX5,RYR3,DTNA,NFIA,NKAIN3,SFXN5,ITPR2,SLC4A4,ATP1A2,PARD3B,FGFR3,ABLIM1,HIF3A,LSAMP,GLIS3,PREX2,PCDH9,ZBTB20,CST3,NPAS3,CDH20,TRPS1,PTPRZ1,GPM6A,SLC1A3,CTNND2,TNIK,GPC5,MAML2,FMN2,NEBL,CPE,RORA,MSI2,NTRK2
1.377e-02	-4.29	positive regulation of synapse assembly	biological process	GO:0051965	65	2	18204	50	NTRK2,NRXN1
1.386e-02	-4.28	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	3	18204	50	RORA,ZBTB20,SLC4A4
1.387e-02	-4.28	non_seminoma	COSMIC cancer mutations	non_seminoma	492	5	16828	49	NTRK2,TNIK,FGFR3,MACF1,BMPR1B
1.397e-02	-4.27	Vinculin	pfam domains	PF01044	5	1	17795	50	CTNNA2
1.397e-02	-4.27	IP_trans	pfam domains	PF02121	5	1	17795	50	PITPNC1
1.397e-02	-4.27	SFXNs	pfam domains	PF03820	5	1	17795	50	SFXN5
1.397e-02	-4.27	Protocadherin	pfam domains	PF08374	5	1	17795	50	PCDH9
1.397e-02	-4.27	FOLN	pfam domains	PF09289	5	1	17795	50	SPARCL1
1.398e-02	-4.27	skin-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma	493	5	16828	49	PREX2,FGFR3,MAML2,NTRK2,LIFR
1.402e-02	-4.27	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	29	NTRK2
1.406e-02	-4.26	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	8	16828	49	CTNND2,FGFR3,SLC4A4,MACF1,LIFR,ATP13A4,PREX2,NTM
1.407e-02	-4.26	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	5	19454	50	FMN2,MACF1,SLC1A3,AHCYL2,DTNA
1.418e-02	-4.26	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	49	NTRK2,CPE,RORA,TNIK,TRPS1,GPM6A,CDH20,NPAS3,PCDH9,PREX2,ABLIM1,ITPR2,NKAIN3,NFIA,SLC1A2,SOX5,NRXN1,ATP13A4,NTM,GLUD1,NHSL1,MACF1,NEBL,GPC5,MAML2,FMN2,CTNND2,SLC1A3,PTPRZ1,ZBTB20,CST3,LSAMP,GLIS3,HIF3A,FGFR3,ATP1A2,PARD3B,PITPNC1,SLC4A4,SFXN5,DTNA,BMPR1B,RYR3,PTGDS,FBXL7,AHCYL2,SPARCL1,LIFR
1.418e-02	-4.26	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	49	DTNA,RYR3,BMPR1B,SPARCL1,LIFR,FBXL7,PTGDS,AHCYL2,SLC1A3,CTNND2,MAML2,GPC5,FMN2,PTPRZ1,NEBL,PARD3B,ATP1A2,FGFR3,SFXN5,SLC4A4,PITPNC1,ZBTB20,CST3,HIF3A,GLIS3,LSAMP,NRXN1,NKAIN3,NFIA,SOX5,SLC1A2,NHSL1,MACF1,ATP13A4,GLUD1,NTM,TNIK,CDH20,GPM6A,TRPS1,NTRK2,RORA,CPE,ABLIM1,ITPR2,PREX2,PCDH9,NPAS3
1.418e-02	-4.26	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	50	SLC1A2,SLC1A3
1.427e-02	-4.25	response to growth factor	biological process	GO:0070848	525	5	18204	50	NFIA,FGFR3,BMPR1B,NTRK2,SOX5
1.429e-02	-4.25	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	12	16828	49	SLC4A4,ATP1A2,FGFR3,PREX2,PTPRZ1,TRPS1,TNIK,SOX5,BMPR1B,DTNA,NTRK2,NFIA
1.433e-02	-4.25	NFIX (nuclear factor I X)	protein interactions	4784	198	3	19454	50	NFIA,SOX5,TRPS1
1.437e-02	-4.24	CTF_NFI_2	prosite domains	PS51080	4	1	12186	44	NFIA
1.437e-02	-4.24	NEBULIN	prosite domains	PS51216	4	1	12186	44	NEBL
1.437e-02	-4.24	CTF_NFI_1	prosite domains	PS00349	4	1	12186	44	NFIA
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	GPM6A,TNIK
1.448e-02	-4.24	skin-face-other-nevus_sebaceous	COSMIC cancer mutations	skin-face-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-ear-other-nevus_sebaceous	COSMIC cancer mutations	skin-ear-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-lichenoid_keratosis	COSMIC cancer mutations	skin-breast-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-lichenoid_keratosis	COSMIC cancer mutations	skin-face-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-nevus_sebaceous	COSMIC cancer mutations	skin-breast-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hip-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-hip-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-chest-other-lichenoid_keratosis	COSMIC cancer mutations	skin-chest-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-adnexal_tumour-syringocystadenoma_papilliferum	COSMIC cancer mutations	skin-adnexal_tumour-syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-scalp-other-nevus_sebaceous	COSMIC cancer mutations	skin-scalp-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-forearm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_arm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_arm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-nevus_sebaceous	COSMIC cancer mutations	skin-shoulder-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-flank-other-lichenoid_keratosis	COSMIC cancer mutations	skin-flank-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	syringocystadenoma_papilliferum	COSMIC cancer mutations	syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-forearm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-lichenoid_keratosis	COSMIC cancer mutations	skin-shoulder-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-nevus_sebaceous	COSMIC cancer mutations	skin-lower_back-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-arm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-arm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hand-other-lichenoid_keratosis	COSMIC cancer mutations	skin-hand-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-other-lichenoid_keratosis	COSMIC cancer mutations	skin-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-nevus_sebaceous	COSMIC cancer mutations	skin-neck-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-lichenoid_keratosis	COSMIC cancer mutations	skin-neck-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.448e-02	-4.24	lichenoid_keratosis	COSMIC cancer mutations	lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	TNIK,GPM6A
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	BMPR1B,PARD3B
1.493e-02	-4.20	presynapse	cellular component	GO:0098793	569	5	19108	49	NTRK2,SLC1A2,NRXN1,GPM6A,TNIK
1.493e-02	-4.20	meninges-meningioma	COSMIC cancer mutations	meninges-meningioma	327	4	16828	49	ITPR2,NFIA,FMN2,FGFR3
1.494e-02	-4.20	carboxylic acid binding	molecular function	GO:0031406	195	3	18094	48	SLC1A3,PTGDS,GLUD1
1.500e-02	-4.20	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	8	16828	49	RYR3,RORA,NTRK2,LIFR,CTNND2,TNIK,FGFR3,MAML2
1.508e-02	-4.19	upper_back	COSMIC cancer mutations	upper_back	328	4	16828	49	MACF1,FGFR3,GPC5,PARD3B
1.512e-02	-4.19	FEV (FEV transcription factor, ETS family member)	protein interactions	54738	202	3	19454	50	TRPS1,NFIA,SOX5
1.517e-02	-4.19	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	48	16828	49	ABLIM1,ITPR2,PREX2,PCDH9,NPAS3,TNIK,CDH20,TRPS1,GPM6A,NTRK2,CPE,RORA,MACF1,ATP13A4,GLUD1,NTM,NRXN1,NFIA,NKAIN3,SLC1A2,SOX5,ATP1A2,PARD3B,FGFR3,SFXN5,PITPNC1,SLC4A4,ZBTB20,CST3,HIF3A,GLIS3,LSAMP,CTNND2,SLC1A3,GPC5,MAML2,FMN2,PTPRZ1,MSI2,NEBL,SPARCL1,LIFR,FBXL7,PTGDS,AHCYL2,DTNA,BMPR1B,RYR3
1.526e-02	-4.18	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	10	18204	50	RORA,NRXN1,ZBTB20,BMPR1B,NTRK2,SFXN5,ATP1A2,SOX5,PTPRZ1,MACF1
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	FGF18 (fibroblast growth factor 18)	protein interactions	8817	6	1	19454	50	FGFR3
1.532e-02	-4.18	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	50	NRXN1
1.532e-02	-4.18	FGF6 (fibroblast growth factor 6)	protein interactions	2251	6	1	19454	50	FGFR3
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	Klhl22 (kelch-like 22)	protein interactions	224023	6	1	19454	50	GLUD1
1.532e-02	-4.18	FGF23 (fibroblast growth factor 23)	protein interactions	8074	6	1	19454	50	FGFR3
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	LIF (LIF interleukin 6 family cytokine)	protein interactions	3976	6	1	19454	50	LIFR
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.541e-02	-4.17	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	5	19454	50	TNIK,DTNA,MACF1,PCDH9,ITPR2
1.547e-02	-4.17	cell-cell contact zone	cellular component	GO:0044291	74	2	19108	49	ATP1A2,PCDH9
1.549e-02	-4.17	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	5	16828	49	FGFR3,NPAS3,SPARCL1,ZBTB20,LIFR
1.549e-02	-4.17	seminoma	COSMIC cancer mutations	seminoma	700	6	16828	49	BMPR1B,NTRK2,PREX2,TRPS1,TNIK,FGFR3
1.552e-02	-4.17	NFIC (nuclear factor I C)	protein interactions	4782	204	3	19454	50	NFIA,SOX5,TRPS1
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	NEBL,ABLIM1
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.581e-02	-4.15	ciliary neurotrophic factor receptor binding	molecular function	GO:0005127	6	1	18094	48	LIFR
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.592e-02	-4.14	cellular process	biological process	GO:0009987	14996	47	18204	50	SOX5,FGFR3,GLIS3,NHSL1,PARD3B,CPE,ATP1A2,SFXN5,CDH20,LSAMP,GPC5,GPM6A,NRXN1,SPARCL1,NEBL,DTNA,ABLIM1,CTNNA2,PITPNC1,GLUD1,SLC4A4,AHCYL2,MSI2,NTRK2,BMPR1B,TNIK,SLC1A2,ZBTB20,FMN2,PREX2,ATP13A4,CST3,RYR3,SLC1A3,PCDH9,LIFR,PTPRZ1,CTNND2,FBXL7,HIF3A,NFIA,NTM,MACF1,RORA,PTGDS,MAML2,ITPR2
1.597e-02	-4.14	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	20	SLC1A3,ATP1A2
1.600e-02	-4.13	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	9	16828	49	ATP13A4,PCDH9,CPE,RYR3,ATP1A2,CTNND2,PARD3B,ITPR2,MACF1
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	AHCYL2,FBXL7,PTGDS,LIFR,SPARCL1,BMPR1B,RYR3,DTNA,HIF3A,LSAMP,GLIS3,CST3,ZBTB20,SFXN5,SLC4A4,ATP1A2,PARD3B,FGFR3,NEBL,MSI2,PTPRZ1,SLC1A3,CTNND2,FMN2,GPC5,MAML2,GLUD1,NTM,ATP13A4,MACF1,NHSL1,SLC1A2,SOX5,NFIA,NKAIN3,NRXN1,PREX2,PCDH9,NPAS3,ITPR2,ABLIM1,CPE,RORA,NTRK2,CDH20,TRPS1,GPM6A,TNIK
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	1	18521	50	NRXN1
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.610e-02	-4.13	LIM	pfam domains	PF00412	69	2	17795	50	NEBL,ABLIM1
1.616e-02	-4.13	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	3	16828	49	PCDH9,GPC5,RYR3
1.622e-02	-4.12	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	8	16828	49	RORA,RYR3,NTRK2,LIFR,MAML2,FGFR3,TNIK,CTNND2
1.627e-02	-4.12	sarcoplasmic reticulum	cellular component	GO:0016529	76	2	19108	49	RYR3,ITPR2
1.630e-02	-4.12	IGc2	smart domains	SM00408	239	4	9717	40	NTM,LSAMP,NTRK2,FGFR3
1.637e-02	-4.11	NEBU	smart domains	SM00227	4	1	9717	40	NEBL
1.637e-02	-4.11	vocal learning	biological process	GO:0042297	6	1	18204	50	NRXN1
1.637e-02	-4.11	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	50	CST3
1.637e-02	-4.11	imitative learning	biological process	GO:0098596	6	1	18204	50	NRXN1
1.637e-02	-4.11	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	1	18204	50	NRXN1
1.637e-02	-4.11	fused antrum stage	biological process	GO:0048165	6	1	18204	50	BMPR1B
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	50	FMN2
1.637e-02	-4.11	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	50	SLC1A3
1.647e-02	-4.11	meninges	COSMIC cancer mutations	meninges	514	5	16828	49	FMN2,NFIA,FGFR3,RYR3,ITPR2
1.647e-02	-4.11	meningioma	COSMIC cancer mutations	meningioma	514	5	16828	49	ITPR2,RYR3,NFIA,FMN2,FGFR3
1.672e-02	-4.09	regulation of ATP metabolic process	biological process	GO:1903578	72	2	18204	50	ZBTB20,SLC4A4
1.674e-02	-4.09	SH3_10	pfam domains	PF17902	6	1	17795	50	MACF1
1.674e-02	-4.09	Glypican	pfam domains	PF01153	6	1	17795	50	GPC5
1.674e-02	-4.09	EF-hand_3	pfam domains	PF09069	6	1	17795	50	DTNA
1.674e-02	-4.09	Syndecan	pfam domains	PF01034	6	1	17795	50	NRXN1
1.674e-02	-4.09	Plectin	pfam domains	PF00681	6	1	17795	50	MACF1
1.674e-02	-4.09	EF-hand_2	pfam domains	PF09068	6	1	17795	50	DTNA
1.674e-02	-4.09	GAS2	pfam domains	PF02187	6	1	17795	50	MACF1
1.680e-02	-4.09	embryonal	COSMIC cancer mutations	embryonal	2659	14	16828	49	MACF1,SPARCL1,FGFR3,PARD3B,GLIS3,NPAS3,PREX2,PTPRZ1,FMN2,MAML2,CTNND2,RORA,RYR3,NFIA
1.680e-02	-4.09	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	14	16828	49	CTNND2,FMN2,MAML2,PTPRZ1,NFIA,RYR3,RORA,PARD3B,FGFR3,SPARCL1,MACF1,PREX2,NPAS3,GLIS3
1.680e-02	-4.09	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	29	NTRK2
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP13A4,ATP1A2
1.709e-02	-4.07	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	11	16828	49	NTRK2,NEBL,RYR3,FMN2,PTPRZ1,CDH20,PREX2,FBXL7,PCDH9,ATP13A4,PITPNC1
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.716e-02	-4.07	peptide metabolic process	biological process	GO:0006518	73	2	18204	50	CPE,SLC1A2
1.716e-02	-4.07	MARCKS (myristoylated alanine rich protein kinase C substrate)	protein interactions	4082	588	5	19454	50	DTNA,AHCYL2,ABLIM1,SLC1A3,MACF1
1.717e-02	-4.06	Nedd4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	25489	78	2	19454	50	NTRK2,BMPR1B
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	MSI2,SOX5
1.718e-02	-4.06	DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2)	protein interactions	27000	212	3	19454	50	GLUD1,TNIK,MACF1
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.735e-02	-4.05	collecting_duct_carcinoma	COSMIC cancer mutations	collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-upper_leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-upper_leg-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-actinic_keratosis	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-actinic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-abdomen-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-abdomen-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-Bowen_disease	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-Bowen_disease	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-epidermal_nevus	COSMIC cancer mutations	skin-head_neck-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-epidermal_nevus	COSMIC cancer mutations	skin-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-lower_back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	kidney-carcinoma-collecting_duct_carcinoma	COSMIC cancer mutations	kidney-carcinoma-collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-benign_melanocytic_nevus-lentiginous_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus-lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-arm-epidermal_nevus	COSMIC cancer mutations	skin-arm-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-lower_leg-epidermal_nevus	COSMIC cancer mutations	skin-lower_leg-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-trunk-epidermal_nevus	COSMIC cancer mutations	skin-trunk-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-face-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-face-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-adnexal_tumour-trichoblastoma	COSMIC cancer mutations	skin-adnexal_tumour-trichoblastoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.735e-02	-4.05	lentiginous_nevus	COSMIC cancer mutations	lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-flank-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-flank-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.747e-02	-4.05	small molecule binding	molecular function	GO:0036094	6197	24	18094	48	SLC1A2,ABLIM1,SLC1A3,PITPNC1,NTRK2,GLIS3,CPE,GLUD1,ATP13A4,FGFR3,DTNA,TNIK,SPARCL1,RORA,BMPR1B,PTGDS,TRPS1,MACF1,ZBTB20,ATP1A2,ITPR2,NRXN1,RYR3,PCDH9
1.749e-02	-4.05	ALPHACATENIN	prints domains	PR00805	4	1	5227	23	CTNNA2
1.750e-02	-4.05	organic acid binding	molecular function	GO:0043177	207	3	18094	48	SLC1A3,PTGDS,GLUD1
1.759e-02	-4.04	PRDM1 (PR/SET domain 1)	protein interactions	639	79	2	19454	50	NFIA,TRPS1
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	NTRK2,NHSL1,TNIK
1.765e-02	-4.04	animal organ morphogenesis	biological process	GO:0009887	988	7	18204	50	CPE,SOX5,NTRK2,ABLIM1,BMPR1B,CTNNA2,FGFR3
1.766e-02	-4.04	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	19	16828	49	GPC5,FMN2,CTNND2,TRPS1,CDH20,RORA,SLC1A2,NEBL,FGFR3,ABLIM1,ATP1A2,PARD3B,ITPR2,SLC4A4,MACF1,PCDH9,PREX2,ATP13A4,AHCYL2
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	FGF5 (fibroblast growth factor 5)	protein interactions	2250	7	1	19454	50	FGFR3
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Ahcyl1 (S-adenosylhomocysteine hydrolase-like 1)	protein interactions	229709	7	1	19454	50	AHCYL2
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.790e-02	-4.02	axonogenesis	biological process	GO:0007409	366	4	18204	50	BMPR1B,CTNNA2,PTPRZ1,NRXN1
1.806e-02	-4.01	amino acid biosynthetic process	biological process	GO:0008652	75	2	18204	50	SLC1A3,GLUD1
1.811e-02	-4.01	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	44	MACF1
1.811e-02	-4.01	Leucine Dehydrogenase, chain A, domain 1	gene3d domains	3.40.50.10860	6	1	14470	44	GLUD1
1.811e-02	-4.01	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	44	MACF1
1.815e-02	-4.01	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	13	16828	49	MACF1,TRPS1,CDH20,SPARCL1,FGFR3,FMN2,SLC1A3,PARD3B,NHSL1,RYR3,NPAS3,NFIA,PREX2
1.815e-02	-4.01	alveolar	COSMIC cancer mutations	alveolar	2414	13	16828	49	NFIA,RYR3,FMN2,SLC1A3,TRPS1,CDH20,NPAS3,PREX2,FGFR3,SPARCL1,NHSL1,PARD3B,MACF1
1.826e-02	-4.00	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	3	19454	50	ABLIM1,NKAIN3,RORA
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	L-leucine binding	molecular function	GO:0070728	7	1	18094	48	GLUD1
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	SOX17 (SRY-box transcription factor 17)	protein interactions	64321	81	2	19454	50	TRPS1,NFIA
1.865e-02	-3.98	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	4	18521	50	TNIK,BMPR1B,NTRK2,FGFR3
1.872e-02	-3.98	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	50	ITPR2,GPM6A,RYR3
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	Hematopoietin_rcpt_Gp130_CS	interpro domains	IPR003529	7	1	18521	50	LIFR
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP1A2,ATP13A4
1.889e-02	-3.97	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	47	16828	49	NTM,GLUD1,ATP13A4,MACF1,NHSL1,SOX5,SLC1A2,NFIA,NKAIN3,NRXN1,NPAS3,PCDH9,PREX2,ITPR2,ABLIM1,RORA,CPE,NTRK2,GPM6A,TRPS1,CDH20,TNIK,AHCYL2,FBXL7,LIFR,SPARCL1,RYR3,BMPR1B,DTNA,LSAMP,GLIS3,HIF3A,ZBTB20,SLC4A4,PITPNC1,SFXN5,FGFR3,PARD3B,ATP1A2,NEBL,MSI2,PTPRZ1,GPC5,FMN2,MAML2,SLC1A3,CTNND2
1.891e-02	-3.97	system process	biological process	GO:0003008	2015	11	18204	50	ATP1A2,NTRK2,PTPRZ1,SLC4A4,ABLIM1,SLC1A3,RYR3,SLC1A2,DTNA,NRXN1,CTNNA2
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.897e-02	-3.96	human chr12p11.23	chromosome location	human chr12p11.23	10	1	26134	50	ITPR2
1.898e-02	-3.96	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	2	18204	50	ATP1A2,NRXN1
1.898e-02	-3.96	neural retina development	biological process	GO:0003407	77	2	18204	50	NTRK2,GPM6A
1.898e-02	-3.96	BMP signaling pathway	biological process	GO:0030509	77	2	18204	50	NFIA,BMPR1B
1.898e-02	-3.96	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	50	NTRK2,MACF1
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	S-adenosylmethionine cycle	biological process	GO:0033353	7	1	18204	50	AHCYL2
1.907e-02	-3.96	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	50	FMN2
1.907e-02	-3.96	positive regulation of transcription of Notch receptor target	biological process	GO:0007221	7	1	18204	50	MAML2
1.907e-02	-3.96	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	50	PTPRZ1
1.907e-02	-3.96	regulation of male germ cell proliferation	biological process	GO:2000254	7	1	18204	50	PTGDS
1.907e-02	-3.96	observational learning	biological process	GO:0098597	7	1	18204	50	NRXN1
1.907e-02	-3.96	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	50	CTNNA2
1.907e-02	-3.96	glial cell fate specification	biological process	GO:0021780	7	1	18204	50	NFIA
1.907e-02	-3.96	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	50	FMN2
1.914e-02	-3.96	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	49	MACF1,FGFR3
1.923e-02	-3.95	Muscle contraction	REACTOME pathways	R-HSA-397014	204	3	10285	29	ATP1A2,ITPR2,RYR3
1.929e-02	-3.95	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	15	16828	49	NPAS3,HIF3A,NTM,ATP1A2,SPARCL1,FGFR3,SLC4A4,MACF1,LIFR,MSI2,NTRK2,NEBL,BMPR1B,MAML2,FMN2
1.929e-02	-3.95	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	15	16828	49	ATP1A2,SPARCL1,FGFR3,SLC4A4,MACF1,LIFR,NPAS3,HIF3A,NTM,MAML2,FMN2,MSI2,NTRK2,BMPR1B,NEBL
1.930e-02	-3.95	DNM3 (dynamin 3)	protein interactions	26052	83	2	19454	50	GPM6A,FGFR3
1.930e-02	-3.95	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	50	NFIA,TRPS1
1.930e-02	-3.95	SYT1 (synaptotagmin 1)	protein interactions	6857	83	2	19454	50	NRXN1,GPM6A
1.943e-02	-3.94	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	GPC5,FMN2,MACF1,ITPR2,ATP13A4,PREX2,SLC1A2
1.943e-02	-3.94	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	ATP13A4,PREX2,SLC1A2,GPC5,FMN2,ITPR2,MACF1
1.944e-02	-3.94	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	2	18204	50	ZBTB20,SLC4A4
1.951e-02	-3.94	TGF_beta_GS	pfam domains	PF08515	7	1	17795	50	BMPR1B
1.951e-02	-3.94	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	50	SPARCL1
1.958e-02	-3.93	FGFR3b ligand binding and activation	REACTOME pathways	R-HSA-190371	7	1	10285	29	FGFR3
1.964e-02	-3.93	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	49	FGFR3,MACF1
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	NTRK2,FGFR3
1.976e-02	-3.92	FBXO2 (F-box protein 2)	protein interactions	26232	403	4	19454	50	FGFR3,NTM,LIFR,PCDH9
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	MACF1,GPM6A,ABLIM1
2.003e-02	-3.91	metal ion binding	molecular function	GO:0046872	4239	18	18094	48	MACF1,ZBTB20,TRPS1,CPE,ITPR2,ATP1A2,NRXN1,PCDH9,RYR3,ABLIM1,SLC1A2,ATP13A4,SPARCL1,DTNA,SLC1A3,RORA,BMPR1B,GLIS3
2.018e-02	-3.90	CFAP298 (cilia and flagella associated protein 298)	protein interactions	56683	85	2	19454	50	TRPS1,FMN2
2.020e-02	-3.90	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	8	19454	50	ITPR2,MSI2,LSAMP,TRPS1,MACF1,GLIS3,NFIA,SOX5
2.021e-02	-3.90	skin-benign_melanocytic_nevus-compound	COSMIC cancer mutations	skin-benign_melanocytic_nevus-compound	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-shoulder-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-shoulder-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	nevus_sebaceous	COSMIC cancer mutations	nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-face-adnexal_tumour-malignant_adnexal_tumour	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-intradermal	COSMIC cancer mutations	skin-benign_melanocytic_nevus-intradermal	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-other-nevus_sebaceous	COSMIC cancer mutations	skin-other-nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-neck-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-neck-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-chest-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-chest-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-adnexal_tumour-trichilemmoma	COSMIC cancer mutations	skin-adnexal_tumour-trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	trichilemmoma	COSMIC cancer mutations	trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	urinary_tract-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma-transitional_cell_carcinoma	7	1	16828	49	FGFR3
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.038e-02	-3.89	CCK (cholecystokinin)	protein interactions	885	8	1	19454	50	CPE
2.038e-02	-3.89	PTGER1 (prostaglandin E receptor 1)	protein interactions	5731	8	1	19454	50	PTGDS
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.042e-02	-3.89	eye development	biological process	GO:0001654	381	4	18204	50	BMPR1B,NTRK2,NFIA,GPM6A
2.044e-02	-3.89	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	25	16828	49	NTRK2,RORA,NEBL,MAML2,CTNND2,SLC1A3,PTPRZ1,ZBTB20,CST3,NPAS3,PREX2,GLIS3,ABLIM1,FGFR3,ATP1A2,SLC4A4,ITPR2,NKAIN3,DTNA,RYR3,SOX5,ATP13A4,SPARCL1,MACF1,LIFR
2.049e-02	-3.89	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	29	RYR3,ATP13A4,ATP1A2
2.053e-02	-3.89	contractile actin filament bundle	cellular component	GO:0097517	86	2	19108	49	NEBL,ABLIM1
2.053e-02	-3.89	stress fiber	cellular component	GO:0001725	86	2	19108	49	NEBL,ABLIM1
2.063e-02	-3.88	EGLN1 (egl-9 family hypoxia inducible factor 1)	protein interactions	54583	86	2	19454	50	FGFR3,HIF3A
2.067e-02	-3.88	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	5	16828	49	BMPR1B,FGFR3,NTRK2,FMN2,TNIK
2.072e-02	-3.88	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	44	NEBL,ABLIM1
2.082e-02	-3.87	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	5	16828	49	BMPR1B,NTRK2,FMN2,TNIK,FGFR3
2.084e-02	-3.87	dendrite	cellular component	GO:0030425	620	5	19108	49	GPM6A,CTNND2,ATP1A2,NTRK2,BMPR1B
2.087e-02	-3.87	adult locomotory behavior	biological process	GO:0008344	81	2	18204	50	PREX2,ATP1A2
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	SPARCL1,RYR3,MACF1
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.105e-02	-3.86	glutamatergic synapse	cellular component	GO:0098978	412	4	19108	49	SLC1A2,SPARCL1,GPM6A,TNIK
2.106e-02	-3.86	Immunoglobulins	gene3d domains	2.60.40.10	721	6	14470	44	LSAMP,NTRK2,LIFR,FGFR3,NTM,PTPRZ1
2.108e-02	-3.86	Kctd5 (potassium channel tetramerisation domain containing 5)	protein interactions	69259	87	2	19454	50	TRPS1,SLC1A3
2.108e-02	-3.86	ZNF608 (zinc finger protein 608)	protein interactions	57507	87	2	19454	50	SOX5,NFIA
2.108e-02	-3.86	NHLH1 (nescient helix-loop-helix 1)	protein interactions	4807	87	2	19454	50	TRPS1,NFIA
2.110e-02	-3.86	dendritic tree	cellular component	GO:0097447	622	5	19108	49	BMPR1B,ATP1A2,NTRK2,CTNND2,GPM6A
2.113e-02	-3.86	visual system development	biological process	GO:0150063	385	4	18204	50	NFIA,GPM6A,BMPR1B,NTRK2
2.118e-02	-3.85	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	26	16828	49	ITPR2,PITPNC1,SLC4A4,FGFR3,ABLIM1,ATP1A2,ZBTB20,PREX2,PTPRZ1,FMN2,MAML2,TNIK,GPC5,CTNND2,CPE,RORA,NTRK2,LIFR,MACF1,NTM,ATP13A4,NRXN1,BMPR1B,SOX5,RYR3,NFIA
2.118e-02	-3.85	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	26	16828	49	SLC4A4,ITPR2,PITPNC1,ATP1A2,ABLIM1,FGFR3,PREX2,ZBTB20,PTPRZ1,CTNND2,MAML2,GPC5,FMN2,TNIK,RORA,CPE,NTRK2,MACF1,LIFR,NTM,ATP13A4,NRXN1,RYR3,SOX5,BMPR1B,NFIA
2.125e-02	-3.85	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	44	ATP1A2,ATP13A4
2.127e-02	-3.85	DST (dystonin)	protein interactions	667	230	3	19454	50	NTRK2,ATP1A2,TNIK
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.144e-02	-3.84	Bile secretion	KEGG pathways	ko04976	71	2	7161	23	ATP1A2,SLC4A4
2.144e-02	-3.84	Bile secretion	KEGG pathways	hsa04976	71	2	7161	23	SLC4A4,ATP1A2
2.147e-02	-3.84	GAR	prosite domains	PS51460	6	1	12186	44	MACF1
2.147e-02	-3.84	GLYPICAN	prosite domains	PS01207	6	1	12186	44	GPC5
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	BMPR1B,TNIK
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	NTRK2,FGFR3,NTM,LSAMP
2.170e-02	-3.83	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	20	NTRK2,RORA,SLC1A3
2.172e-02	-3.83	regulation of cell junction assembly	biological process	GO:1901888	217	3	18204	50	NTRK2,MACF1,NRXN1
2.177e-02	-3.83	glutamate catabolic process	biological process	GO:0006538	8	1	18204	50	GLUD1
2.177e-02	-3.83	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	50	RORA
2.177e-02	-3.83	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	50	RORA
2.177e-02	-3.83	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	50	FMN2
2.177e-02	-3.83	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	50	SLC1A3
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.177e-02	-3.83	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	50	RORA
2.177e-02	-3.83	insulin processing	biological process	GO:0030070	8	1	18204	50	CPE
2.177e-02	-3.83	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	50	CTNNA2
2.177e-02	-3.83	regulation of germ cell proliferation	biological process	GO:1905936	8	1	18204	50	PTGDS
2.182e-02	-3.83	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	23	SLC4A4
2.182e-02	-3.83	PITRANSFER	prints domains	PR00391	5	1	5227	23	PITPNC1
2.185e-02	-3.82	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	9	16828	49	CTNND2,NRXN1,GPC5,FMN2,TNIK,TRPS1,SLC4A4,RYR3,LSAMP
2.186e-02	-3.82	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	49	PREX2,PARD3B,FMN2,SLC4A4,ITPR2
2.199e-02	-3.82	SOX10 (SRY-box transcription factor 10)	protein interactions	6663	89	2	19454	50	TRPS1,NFIA
2.199e-02	-3.82	PLEKHA2 (pleckstrin homology domain containing A2)	protein interactions	59339	89	2	19454	50	DTNA,AHCYL2
2.221e-02	-3.81	sensory system development	biological process	GO:0048880	391	4	18204	50	BMPR1B,NTRK2,NFIA,GPM6A
2.224e-02	-3.81	glial cell differentiation	biological process	GO:0010001	219	3	18204	50	NFIA,PTPRZ1,NTRK2
2.224e-02	-3.81	HMG20A (high mobility group 20A)	protein interactions	10363	234	3	19454	50	SOX5,NFIA,DTNA
2.226e-02	-3.80	VHP	pfam domains	PF02209	8	1	17795	50	ABLIM1
2.233e-02	-3.80	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	50	NKAIN3,ATP1A2
2.233e-02	-3.80	L-amino acid transport	biological process	GO:0015807	84	2	18204	50	SLC1A2,SLC1A3
2.234e-02	-3.80	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	29	GPC5
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	FMN2,DTNA
2.249e-02	-3.79	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	3	19454	50	MACF1,NTRK2,DTNA
2.250e-02	-3.79	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	50	NRXN1,ATP1A2,SLC1A3
2.283e-02	-3.78	oligodendrocyte differentiation	biological process	GO:0048709	85	2	18204	50	NTRK2,PTPRZ1
2.285e-02	-3.78	platelet dense tubular network membrane	cellular component	GO:0031095	9	1	19108	49	ITPR2
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	FGFR3
2.290e-02	-3.78	GUSBP1 (GUSB pseudogene 1)	protein interactions	728411	9	1	19454	50	FGFR3
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	GPM6A,NTM
2.292e-02	-3.78	FOXI1 (forkhead box I1)	protein interactions	2299	91	2	19454	50	TRPS1,NFIA
2.299e-02	-3.77	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	3	19454	50	SOX5,GPM6A,ITPR2
2.306e-02	-3.77	trichoblastoma	COSMIC cancer mutations	trichoblastoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.306e-02	-3.77	actinic_keratosis	COSMIC cancer mutations	actinic_keratosis	8	1	16828	49	FGFR3
2.306e-02	-3.77	junctional	COSMIC cancer mutations	junctional	8	1	16828	49	FGFR3
2.317e-02	-3.76	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	2	7161	23	ATP1A2,ITPR2
2.317e-02	-3.76	Thyroid hormone synthesis	KEGG pathways	ko04918	74	2	7161	23	ATP1A2,ITPR2
2.318e-02	-3.76	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	3	16828	49	ATP13A4,NTM,SLC4A4
2.325e-02	-3.76	forearm	COSMIC cancer mutations	forearm	81	2	16828	49	PREX2,FGFR3
2.329e-02	-3.76	actomyosin	cellular component	GO:0042641	92	2	19108	49	ABLIM1,NEBL
2.339e-02	-3.76	POTEI (POTE ankyrin domain family member I)	protein interactions	653269	92	2	19454	50	FGFR3,DTNA
2.339e-02	-3.76	SOX9 (SRY-box transcription factor 9)	protein interactions	6662	92	2	19454	50	TRPS1,NFIA
2.339e-02	-3.76	FNTA (farnesyltransferase, CAAX box, subunit alpha)	protein interactions	2339	92	2	19454	50	TNIK,FGFR3
2.376e-02	-3.74	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	23	ATP1A2,ITPR2
2.376e-02	-3.74	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	23	ATP1A2,ITPR2
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	ABLIM1,BMPR1B
2.401e-02	-3.73	-	gene3d domains	2.80.10.50	79	2	14470	44	ITPR2,RYR3
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.404e-02	-3.73	Aminoacid_DH-like_N_sf	interpro domains	IPR046346	9	1	18521	50	GLUD1
2.404e-02	-3.73	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	50	CST3
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.405e-02	-3.73	central_nervous_system-brain-atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	central_nervous_system-brain-atypical_teratoid-rhabdoid_tumour	213	3	16828	49	PCDH9,FGFR3,FMN2
2.405e-02	-3.73	atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	atypical_teratoid-rhabdoid_tumour	213	3	16828	49	FMN2,FGFR3,PCDH9
2.407e-02	-3.73	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	44	ABLIM1
2.433e-02	-3.72	Endochondral Ossification	WikiPathways	WP474	65	2	5310	20	FGFR3,SOX5
2.435e-02	-3.72	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	50	FGFR3,NTRK2
2.435e-02	-3.72	QSER1 (glutamine and serine rich 1)	protein interactions	79832	94	2	19454	50	NFIA,SOX5
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	ABLIM1,TNIK
2.435e-02	-3.72	FOXP4 (forkhead box P4)	protein interactions	116113	94	2	19454	50	NFIA,SOX5
2.437e-02	-3.71	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	20	16828	49	LIFR,PITPNC1,ITPR2,MACF1,FGFR3,HIF3A,FBXL7,PREX2,PCDH9,TRPS1,PTPRZ1,NRXN1,CTNND2,TNIK,MAML2,BMPR1B,SOX5,RORA,MSI2,NTRK2
2.437e-02	-3.71	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	20	16828	49	TNIK,MAML2,CTNND2,NRXN1,TRPS1,PTPRZ1,NTRK2,MSI2,RORA,BMPR1B,SOX5,FGFR3,LIFR,ITPR2,PITPNC1,MACF1,PREX2,PCDH9,FBXL7,HIF3A
2.438e-02	-3.71	postsynapse	cellular component	GO:0098794	646	5	19108	49	NTRK2,ATP1A2,GPM6A,TNIK,CTNND2
2.445e-02	-3.71	GAS2	smart domains	SM00243	6	1	9717	40	MACF1
2.446e-02	-3.71	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	50	CTNNA2
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.446e-02	-3.71	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	50	NRXN1
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.446e-02	-3.71	cyclooxygenase pathway	biological process	GO:0019371	9	1	18204	50	PTGDS
2.446e-02	-3.71	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	50	CTNNA2
2.446e-02	-3.71	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	50	ATP13A4
2.459e-02	-3.71	human chr5p15.1	chromosome location	human chr5p15.1	13	1	26134	50	FBXL7
2.468e-02	-3.70	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	6	16828	49	FGFR3,TNIK,CTNND2,NTRK2,SOX5,BMPR1B
2.468e-02	-3.70	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	6	16828	49	SOX5,BMPR1B,NTRK2,TNIK,FGFR3,CTNND2
2.468e-02	-3.70	skeletal system morphogenesis	biological process	GO:0048705	228	3	18204	50	FGFR3,BMPR1B,SOX5
2.484e-02	-3.70	vesicle	cellular component	GO:0031982	4141	17	19108	49	FGFR3,CPE,NTRK2,PTGDS,CST3,ATP1A2,ATP13A4,NEBL,ITPR2,GPM6A,TNIK,SLC4A4,SLC1A2,FMN2,NRXN1,SLC1A3,LIFR
2.496e-02	-3.69	DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	GO:0000981	1355	8	18094	48	RORA,NFIA,GLIS3,TRPS1,ZBTB20,HIF3A,SOX5,NPAS3
2.501e-02	-3.69	GS	prosite domains	PS51256	7	1	12186	44	BMPR1B
2.501e-02	-3.69	HEMATOPO_REC_L_F2	prosite domains	PS01353	7	1	12186	44	LIFR
2.501e-02	-3.69	Band_3_cyto	pfam domains	PF07565	9	1	17795	50	SLC4A4
2.501e-02	-3.69	Activin_recp	pfam domains	PF01064	9	1	17795	50	BMPR1B
2.521e-02	-3.68	actin filament bundle	cellular component	GO:0032432	96	2	19108	49	NEBL,ABLIM1
2.521e-02	-3.68	sarcoplasm	cellular component	GO:0016528	96	2	19108	49	RYR3,ITPR2
2.536e-02	-3.67	perineuronal net	cellular component	GO:0072534	10	1	19108	49	PTPRZ1
2.539e-02	-3.67	regulation of purine nucleotide metabolic process	biological process	GO:1900542	90	2	18204	50	SLC4A4,ZBTB20
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	BANK1 (B cell scaffold protein with ankyrin repeats 1)	protein interactions	55024	10	1	19454	50	ITPR2
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	SERPINB11 (serpin family B member 11)	protein interactions	89778	10	1	19454	50	CPE
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.548e-02	-3.67	forebrain development	biological process	GO:0030900	408	4	18204	50	PCDH9,NTRK2,ATP1A2,SLC1A2
2.551e-02	-3.67	lipid binding	molecular function	GO:0008289	861	6	18094	48	PTGDS,RORA,ATP1A2,ITPR2,PITPNC1,PARD3B
2.585e-02	-3.66	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	3	19454	50	SOX5,TNIK,NFIA
2.589e-02	-3.65	shoulder	COSMIC cancer mutations	shoulder	387	4	16828	49	MACF1,CPE,FGFR3,PREX2
2.591e-02	-3.65	skin-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-other-seborrhoeic_keratosis	9	1	16828	49	FGFR3
2.591e-02	-3.65	epidermal_nevus	COSMIC cancer mutations	epidermal_nevus	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-benign_melanocytic_nevus-congenital	COSMIC cancer mutations	skin-benign_melanocytic_nevus-congenital	9	1	16828	49	FGFR3
2.591e-02	-3.65	Bowen_disease	COSMIC cancer mutations	Bowen_disease	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	COSMIC cancer mutations	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	in_situ_epithelial_neoplasm	COSMIC cancer mutations	in_situ_epithelial_neoplasm	9	1	16828	49	FGFR3
2.591e-02	-3.65	compound	COSMIC cancer mutations	compound	9	1	16828	49	FGFR3
2.592e-02	-3.65	regulation of nucleotide metabolic process	biological process	GO:0006140	91	2	18204	50	ZBTB20,SLC4A4
2.592e-02	-3.65	cellular response to BMP stimulus	biological process	GO:0071773	91	2	18204	50	BMPR1B,NFIA
2.592e-02	-3.65	response to BMP	biological process	GO:0071772	91	2	18204	50	NFIA,BMPR1B
2.613e-02	-3.64	ACTIVIN2R	prints domains	PR00653	6	1	5227	23	BMPR1B
2.621e-02	-3.64	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	44	16828	49	MACF1,LIFR,NHSL1,SPARCL1,GLUD1,NTM,AHCYL2,ATP13A4,FBXL7,PTGDS,NRXN1,SOX5,RYR3,SLC1A2,BMPR1B,NKAIN3,SFXN5,SLC4A4,ITPR2,PARD3B,ATP1A2,FGFR3,HIF3A,GLIS3,LSAMP,PREX2,PCDH9,NPAS3,ZBTB20,CST3,CDH20,GPM6A,PTPRZ1,TRPS1,CTNND2,SLC1A3,GPC5,TNIK,FMN2,MAML2,NEBL,RORA,CPE,NTRK2
2.622e-02	-3.64	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	48	ATP13A4
2.622e-02	-3.64	neurotrophin binding	molecular function	GO:0043121	10	1	18094	48	NTRK2
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	LSAMP,GPM6A
2.631e-02	-3.64	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	2	19454	50	NTRK2,FGFR3
2.637e-02	-3.64	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	50	PREX2,FGFR3,ITPR2,TNIK,RYR3,ATP1A2
2.645e-02	-3.63	establishment of localization	biological process	GO:0051234	3887	17	18204	50	PARD3B,PITPNC1,SLC1A2,NTRK2,GPM6A,ITPR2,NRXN1,ATP13A4,RYR3,SLC1A3,PTGDS,MACF1,SLC4A4,FMN2,ATP1A2,SFXN5,CPE
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.646e-02	-3.63	human chr2p13.2	chromosome location	human chr2p13.2	14	1	26134	50	SFXN5
2.666e-02	-3.62	TCF7L2 (transcription factor 7 like 2)	protein interactions	6934	251	3	19454	50	CTNNA2,LIFR,NFIA
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.680e-02	-3.62	TNKS (tankyrase)	protein interactions	8658	99	2	19454	50	PCDH9,TNIK
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	TRPS1,SOX5
2.683e-02	-3.62	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	48	ATP1A2,ATP13A4
2.690e-02	-3.62	anterograde trans-synaptic signaling	biological process	GO:0098916	415	4	18204	50	NRXN1,SLC1A2,SLC1A3,DTNA
2.690e-02	-3.62	chemical synaptic transmission	biological process	GO:0007268	415	4	18204	50	SLC1A3,SLC1A2,DTNA,NRXN1
2.693e-02	-3.61	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	3	19454	50	NHSL1,TNIK,NTRK2
2.693e-02	-3.61	CRX (cone-rod homeobox)	protein interactions	1406	252	3	19454	50	TRPS1,NFIA,SOX5
2.705e-02	-3.61	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	44	NEBL,ABLIM1
2.705e-02	-3.61	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	44	NEBL,ABLIM1
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	1	18204	50	NRXN1
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	50	NRXN1
2.714e-02	-3.61	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	50	NRXN1
2.714e-02	-3.61	establishment of centrosome localization	biological process	GO:0051660	10	1	18204	50	PARD3B
2.714e-02	-3.61	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	50	NTRK2
2.714e-02	-3.61	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	50	NTRK2
2.714e-02	-3.61	retinal rod cell development	biological process	GO:0046548	10	1	18204	50	NTRK2
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	NTRK2,FGFR3
2.731e-02	-3.60	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	50	ABLIM1,NRXN1
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	GPM6A,ATP1A2
2.737e-02	-3.60	pancreas-other-adenoma	COSMIC cancer mutations	pancreas-other-adenoma	224	3	16828	49	PCDH9,CTNND2,BMPR1B
2.748e-02	-3.59	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	29	NTM,LSAMP
2.756e-02	-3.59	muscle contraction	biological process	GO:0006936	238	3	18204	50	ATP1A2,DTNA,RYR3
2.775e-02	-3.58	PAS_3	pfam domains	PF08447	10	1	17795	50	NPAS3
2.775e-02	-3.58	HCO3_cotransp	pfam domains	PF00955	10	1	17795	50	SLC4A4
2.776e-02	-3.58	DYNLL2 (dynein light chain LC8-type 2)	protein interactions	140735	255	3	19454	50	TRPS1,NFIA,NHSL1
2.781e-02	-3.58	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	50	FGFR3,CTNNA2
2.785e-02	-3.58	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	29	FGFR3
2.786e-02	-3.58	platelet dense tubular network	cellular component	GO:0031094	11	1	19108	49	ITPR2
2.786e-02	-3.58	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	49	PTPRZ1
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	ITPR2
2.792e-02	-3.58	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	50	NRXN1
2.792e-02	-3.58	CCDC17 (coiled-coil domain containing 17)	protein interactions	149483	11	1	19454	50	FGFR3
2.792e-02	-3.58	PTGDR (prostaglandin D2 receptor)	protein interactions	5729	11	1	19454	50	PTGDS
2.792e-02	-3.58	NTS (neurotensin)	protein interactions	4922	11	1	19454	50	CPE
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.795e-02	-3.58	secretion by cell	biological process	GO:0032940	420	4	18204	50	NRXN1,PTGDS,NTRK2,CPE
2.795e-02	-3.58	axon development	biological process	GO:0061564	420	4	18204	50	CTNNA2,NRXN1,PTPRZ1,BMPR1B
2.802e-02	-3.58	RNA polymerase II transcription regulatory region sequence-specific DNA binding	molecular function	GO:0000977	1385	8	18094	48	GLIS3,NFIA,RORA,SOX5,NPAS3,HIF3A,ZBTB20,TRPS1
2.807e-02	-3.57	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	50	RYR3,ITPR2
2.809e-02	-3.57	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	50	NTRK2,BMPR1B,FGFR3,LIFR,NFIA
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.847e-02	-3.56	GS	smart domains	SM00467	7	1	9717	40	BMPR1B
2.847e-02	-3.56	PLEC	smart domains	SM00250	7	1	9717	40	MACF1
2.853e-02	-3.56	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	44	TRPS1
2.853e-02	-3.56	HP	prosite domains	PS51089	8	1	12186	44	ABLIM1
2.860e-02	-3.55	PLCG1 (phospholipase C gamma 1)	protein interactions	5335	258	3	19454	50	FGFR3,NTRK2,LIFR
2.862e-02	-3.55	pleura	COSMIC cancer mutations	pleura	4914	21	16828	49	FMN2,MAML2,TNIK,CTNND2,TRPS1,PTPRZ1,NTRK2,MSI2,RORA,BMPR1B,NEBL,SOX5,FGFR3,PITPNC1,ITPR2,LIFR,PREX2,FBXL7,ATP13A4,NTM,HIF3A
2.865e-02	-3.55	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	46	16828	49	FGFR3,ATP1A2,PARD3B,PITPNC1,SLC4A4,SFXN5,ZBTB20,LSAMP,GLIS3,HIF3A,FMN2,GPC5,MAML2,SLC1A3,CTNND2,PTPRZ1,MSI2,NEBL,SPARCL1,LIFR,PTGDS,FBXL7,AHCYL2,DTNA,BMPR1B,RYR3,ABLIM1,ITPR2,NPAS3,PCDH9,PREX2,TNIK,TRPS1,GPM6A,CDH20,NTRK2,CPE,RORA,MACF1,ATP13A4,NTM,GLUD1,NRXN1,NFIA,SLC1A2,SOX5
2.875e-02	-3.55	intradermal	COSMIC cancer mutations	intradermal	10	1	16828	49	FGFR3
2.875e-02	-3.55	lung-carcinoma-pleomorphic_carcinoma	COSMIC cancer mutations	lung-carcinoma-pleomorphic_carcinoma	10	1	16828	49	FGFR3
2.875e-02	-3.55	renal_cell_carcinoma_unclassified	COSMIC cancer mutations	renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.875e-02	-3.55	cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	kidney-carcinoma-renal_cell_carcinoma_unclassified	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.880e-02	-3.55	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	48	NRXN1
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.881e-02	-3.55	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	34	16828	49	NHSL1,MACF1,LIFR,PTGDS,FBXL7,AHCYL2,NKAIN3,NFIA,RYR3,SOX5,BMPR1B,FGFR3,PARD3B,ATP1A2,SLC4A4,ITPR2,PITPNC1,PCDH9,PREX2,LSAMP,GLIS3,HIF3A,MAML2,TNIK,GPC5,FMN2,CTNND2,PTPRZ1,TRPS1,CDH20,NTRK2,MSI2,RORA,NEBL
2.881e-02	-3.55	transport	biological process	GO:0006810	3615	16	18204	50	NTRK2,PITPNC1,SLC1A2,FMN2,MACF1,SLC4A4,SFXN5,ATP1A2,CPE,NRXN1,ITPR2,GPM6A,RYR3,SLC1A3,PTGDS,ATP13A4
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	BMPR1B,GPM6A
2.892e-02	-3.54	Bile Acid Indirect Signalling Pathway	SMPDB pathways	SMP0086851	8	1	1369	5	FGFR3
2.892e-02	-3.54	Glucose-Alanine Cycle	SMPDB pathways	SMP0000127	8	1	1369	5	GLUD1
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A2,SLC1A3
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	NTM,LSAMP,FGFR3,NTRK2
2.917e-02	-3.53	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	50	SLC1A3,SLC1A2
2.917e-02	-3.53	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	16	16828	49	GLIS3,PREX2,PCDH9,ATP13A4,PITPNC1,LIFR,ITPR2,MACF1,FGFR3,ATP1A2,NEBL,PTPRZ1,GPC5,FMN2,NRXN1,CTNND2
2.920e-02	-3.53	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	4	19454	50	DTNA,MACF1,FMN2,CTNND2
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.936e-02	-3.53	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	2	19454	50	SPARCL1,ABLIM1
2.940e-02	-3.53	GSK3A (glycogen synthase kinase 3 alpha)	protein interactions	2931	456	4	19454	50	MACF1,NHSL1,TNIK,GLUD1
2.946e-02	-3.52	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	3	19454	50	FMN2,MACF1,DTNA
2.971e-02	-3.52	response to abiotic stimulus	biological process	GO:0009628	1100	7	18204	50	FMN2,ATP1A2,NRXN1,ITPR2,SLC1A2,SLC1A3,RORA
2.972e-02	-3.52	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	17	16828	49	SOX5,BMPR1B,RORA,MSI2,NTRK2,PTPRZ1,TRPS1,CTNND2,MAML2,TNIK,HIF3A,PREX2,FBXL7,LIFR,ITPR2,PITPNC1,FGFR3
2.980e-02	-3.51	organic substance transport	biological process	GO:0071702	1881	10	18204	50	NTRK2,SFXN5,CPE,FMN2,SLC4A4,MACF1,SLC1A2,SLC1A3,ATP13A4,PITPNC1
2.981e-02	-3.51	polyamine transport	biological process	GO:0015846	11	1	18204	50	ATP13A4
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.981e-02	-3.51	glutamate secretion	biological process	GO:0014047	11	1	18204	50	NTRK2
2.981e-02	-3.51	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	50	BMPR1B
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.988e-02	-3.51	BEND3 (BEN domain containing 3)	protein interactions	57673	105	2	19454	50	TRPS1,TNIK
2.999e-02	-3.51	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	50	NTRK2,MACF1,PTPRZ1
3.000e-02	-3.51	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	44	SLC4A4
3.028e-02	-3.50	bone morphogenesis	biological process	GO:0060349	99	2	18204	50	FGFR3,BMPR1B
3.030e-02	-3.50	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	49	PREX2,CTNND2,FMN2,FGFR3,ITPR2
3.034e-02	-3.50	response to wounding	biological process	GO:0009611	431	4	18204	50	SLC1A2,SLC1A3,MACF1,NFIA
3.035e-02	-3.49	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	49	PTPRZ1
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.036e-02	-3.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	5	19454	50	SLC1A3,MACF1,PCDH9,FMN2,TNIK
3.042e-02	-3.49	CTF1 (cardiotrophin 1)	protein interactions	1489	12	1	19454	50	LIFR
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	PROK2 (prokineticin 2)	protein interactions	60675	12	1	19454	50	CPE
3.049e-02	-3.49	PAS_11	pfam domains	PF14598	11	1	17795	50	HIF3A
3.058e-02	-3.49	CTNNB1 (catenin beta 1)	protein interactions	1499	926	6	19454	50	PTPRZ1,CTNND2,CTNNA2,PARD3B,NHSL1,DTNA
3.063e-02	-3.49	spleen	COSMIC cancer mutations	spleen	408	4	16828	49	PARD3B,TNIK,NTM,PTPRZ1
3.067e-02	-3.48	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	2	12186	44	CPE,GLIS3
3.079e-02	-3.48	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	50	ATP13A4,ATP1A2,RYR3,SLC1A3
3.100e-02	-3.47	RHOA (ras homolog family member A)	protein interactions	387	1186	7	19454	50	FMN2,ITPR2,MACF1,PARD3B,CTNNA2,PREX2,GLUD1
3.138e-02	-3.46	inositol 1,4,5 trisphosphate binding	molecular function	GO:0070679	12	1	18094	48	ITPR2
3.147e-02	-3.46	PAX8 (paired box 8)	protein interactions	7849	108	2	19454	50	TRPS1,NFIA
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	MSI2,RYR3
3.147e-02	-3.46	CAMKV (CaM kinase like vesicle associated)	protein interactions	79012	108	2	19454	50	AHCYL2,GPM6A
3.149e-02	-3.46	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	50	ABLIM1,NHSL1,MACF1,FMN2
3.157e-02	-3.46	calcium ion transport	biological process	GO:0006816	251	3	18204	50	GPM6A,ITPR2,RYR3
3.158e-02	-3.46	kidney-other-oncocytoma	COSMIC cancer mutations	kidney-other-oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-scalp-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	congenital	COSMIC cancer mutations	congenital	11	1	16828	49	FGFR3
3.158e-02	-3.46	pleomorphic_carcinoma	COSMIC cancer mutations	pleomorphic_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	prostate-hyperplasia	COSMIC cancer mutations	prostate-hyperplasia	11	1	16828	49	FGFR3
3.158e-02	-3.46	oncocytoma	COSMIC cancer mutations	oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	seborrhoeic_keratosis	COSMIC cancer mutations	seborrhoeic_keratosis	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.158e-02	-3.46	skin-neck-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-neck-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.168e-02	-3.45	Methionine degradation	KEGG pathways	M00035	10	1	7161	23	AHCYL2
3.168e-02	-3.45	Methionine degradation	KEGG pathways	hsa_M00035	10	1	7161	23	AHCYL2
3.193e-02	-3.44	Lipocalin_CS	interpro domains	IPR022272	12	1	18521	50	PTGDS
3.193e-02	-3.44	Lipocalin	interpro domains	IPR002345	12	1	18521	50	PTGDS
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.204e-02	-3.44	CYSTATIN	prosite domains	PS00287	9	1	12186	44	CST3
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	SPARCL1,NHSL1,LIFR,MACF1,PTGDS,FBXL7,ATP13A4,AHCYL2,NTM,GLUD1,NRXN1,NFIA,DTNA,BMPR1B,SLC1A2,RYR3,SOX5,FGFR3,ABLIM1,ATP1A2,PARD3B,ITPR2,PITPNC1,SLC4A4,SFXN5,NPAS3,ZBTB20,CST3,PCDH9,PREX2,GLIS3,LSAMP,HIF3A,MAML2,TNIK,GPC5,FMN2,SLC1A3,CTNND2,TRPS1,PTPRZ1,GPM6A,CDH20,NTRK2,MSI2,CPE,RORA,NEBL
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	NRXN1,NFIA,DTNA,SLC1A2,BMPR1B,SOX5,RYR3,SPARCL1,NHSL1,LIFR,MACF1,PTGDS,ATP13A4,FBXL7,AHCYL2,NTM,GLUD1,FMN2,TNIK,GPC5,MAML2,SLC1A3,CTNND2,TRPS1,PTPRZ1,GPM6A,CDH20,NTRK2,MSI2,CPE,RORA,NEBL,FGFR3,ABLIM1,ATP1A2,PARD3B,ITPR2,PITPNC1,SLC4A4,SFXN5,ZBTB20,NPAS3,CST3,PREX2,PCDH9,GLIS3,LSAMP,HIF3A
3.247e-02	-3.43	VHP	smart domains	SM00153	8	1	9717	40	ABLIM1
3.248e-02	-3.43	dicarboxylic acid biosynthetic process	biological process	GO:0043650	12	1	18204	50	GLUD1
3.248e-02	-3.43	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	50	CST3
3.248e-02	-3.43	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	50	BMPR1B
3.248e-02	-3.43	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	50	BMPR1B
3.248e-02	-3.43	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	50	CST3
3.248e-02	-3.43	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	50	SLC1A2
3.250e-02	-3.43	DNA-binding transcription repressor activity, RNA polymerase II-specific	molecular function	GO:0001227	263	3	18094	48	GLIS3,ZBTB20,TRPS1
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	BMPR1B,PARD3B
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	ATP1A2,RORA
3.279e-02	-3.42	large_intestine-colon-carcinoma	COSMIC cancer mutations	large_intestine-colon-carcinoma	2612	13	16828	49	ITPR2,MACF1,AHCYL2,PREX2,PCDH9,TRPS1,PTPRZ1,GPC5,FMN2,NRXN1,SLC1A3,CPE,RORA
3.281e-02	-3.42	distal axon	cellular component	GO:0150034	273	3	19108	49	NTRK2,PCDH9,GPM6A
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.291e-02	-3.41	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	50	NRXN1
3.296e-02	-3.41	Carboxypeptidase-like, regulatory domain	gene3d domains	2.60.40.1120	11	1	14470	44	CPE
3.308e-02	-3.41	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	50	MACF1,CTNNA2,NTRK2,TNIK
3.310e-02	-3.41	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	46	16828	49	ITPR2,ABLIM1,NPAS3,PCDH9,PREX2,GPM6A,TRPS1,CDH20,TNIK,RORA,CPE,NTRK2,MACF1,NTM,GLUD1,ATP13A4,NRXN1,SOX5,SLC1A2,NFIA,SLC4A4,PITPNC1,SFXN5,FGFR3,PARD3B,ATP1A2,LSAMP,GLIS3,HIF3A,ZBTB20,PTPRZ1,GPC5,FMN2,MAML2,CTNND2,SLC1A3,NEBL,MSI2,LIFR,SPARCL1,AHCYL2,PTGDS,FBXL7,RYR3,BMPR1B,DTNA
3.310e-02	-3.41	bladder	COSMIC cancer mutations	bladder	14112	46	16828	49	NPAS3,ZBTB20,PREX2,PCDH9,GLIS3,LSAMP,HIF3A,ABLIM1,FGFR3,PARD3B,ATP1A2,SLC4A4,ITPR2,PITPNC1,SFXN5,NTRK2,MSI2,RORA,CPE,NEBL,TNIK,GPC5,FMN2,MAML2,CTNND2,SLC1A3,PTPRZ1,GPM6A,TRPS1,CDH20,PTGDS,FBXL7,ATP13A4,NTM,AHCYL2,GLUD1,SPARCL1,MACF1,LIFR,NFIA,DTNA,RYR3,SOX5,BMPR1B,SLC1A2,NRXN1
3.321e-02	-3.40	MH1	pfam domains	PF03165	12	1	17795	50	NFIA
3.321e-02	-3.40	CarboxypepD_reg	pfam domains	PF13620	12	1	17795	50	CPE
3.333e-02	-3.40	Signaling by activated point mutants of FGFR3	REACTOME pathways	R-HSA-1839130	12	1	10285	29	FGFR3
3.333e-02	-3.40	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	29	HIF3A
3.333e-02	-3.40	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	29	GPC5
3.333e-02	-3.40	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	29	GPC5
3.333e-02	-3.40	FGFR3 mutant receptor activation	REACTOME pathways	R-HSA-2033514	12	1	10285	29	FGFR3
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	TRPS1,MACF1
3.368e-02	-3.39	large_intestine-rectum-adenoma	COSMIC cancer mutations	large_intestine-rectum-adenoma	99	2	16828	49	LIFR,NTRK2
3.387e-02	-3.39	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	8	16828	49	ZBTB20,NPAS3,NTM,PARD3B,ATP1A2,SLC4A4,MACF1,TRPS1
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.405e-02	-3.38	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	6	19454	50	NFIA,ZBTB20,ATP13A4,SLC1A3,CTNND2,TRPS1
3.425e-02	-3.37	signal transduction	biological process	GO:0007165	4637	19	18204	50	NTRK2,BMPR1B,FGFR3,CTNND2,SPARCL1,DTNA,TNIK,NFIA,PITPNC1,ATP1A2,CPE,MACF1,FMN2,PREX2,RORA,RYR3,MAML2,LIFR,ITPR2
3.425e-02	-3.37	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	50	SLC1A3,GPM6A,NEBL
3.432e-02	-3.37	oogenesis	biological process	GO:0048477	106	2	18204	50	BMPR1B,FMN2
3.435e-02	-3.37	LIM	smart domains	SM00132	71	2	9717	40	ABLIM1,NEBL
3.438e-02	-3.37	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	19	16828	49	PREX2,PCDH9,GLIS3,HIF3A,ABLIM1,FGFR3,NHSL1,ATP1A2,MACF1,LIFR,DTNA,SOX5,RYR3,FMN2,CTNND2,SLC1A3,PTPRZ1,GPM6A,TRPS1
3.438e-02	-3.37	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	19	16828	49	DTNA,SOX5,RYR3,CTNND2,SLC1A3,FMN2,PTPRZ1,GPM6A,TRPS1,PCDH9,PREX2,HIF3A,GLIS3,NHSL1,ATP1A2,ABLIM1,FGFR3,MACF1,LIFR
3.439e-02	-3.37	ear	COSMIC cancer mutations	ear	624	5	16828	49	LIFR,FGFR3,ZBTB20,SPARCL1,NPAS3
3.440e-02	-3.37	skin-face-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-basal_cell_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.440e-02	-3.37	cervix-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	cervix-carcinoma-mixed_adenosquamous_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-benign_melanocytic_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus	12	1	16828	49	FGFR3
3.440e-02	-3.37	DNA-binding transcription factor activity	molecular function	GO:0003700	1441	8	18094	48	RORA,NFIA,GLIS3,ZBTB20,TRPS1,HIF3A,NPAS3,SOX5
3.469e-02	-3.36	GATAZNFINGER	prints domains	PR00619	8	1	5227	23	TRPS1
3.469e-02	-3.36	LIPOCALIN	prints domains	PR00179	8	1	5227	23	PTGDS
3.484e-02	-3.36	cell-cell adhesion via plasma-membrane adhesion molecules	biological process	GO:0098742	261	3	18204	50	CDH20,SPARCL1,PCDH9
3.500e-02	-3.35	Cadherin_CS	interpro domains	IPR020894	109	2	18521	50	PCDH9,CDH20
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	ITPR2,RYR3
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	50	RORA
3.514e-02	-3.35	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	50	NRXN1
3.514e-02	-3.35	prepulse inhibition	biological process	GO:0060134	13	1	18204	50	CTNNA2
3.514e-02	-3.35	glial cell fate commitment	biological process	GO:0021781	13	1	18204	50	NFIA
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	50	RORA
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	BMPR1B,SOX5
3.530e-02	-3.34	TBXT (T-box transcription factor T)	protein interactions	6862	115	2	19454	50	NFIA,TRPS1
3.533e-02	-3.34	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	50	CTNNA2,MACF1,GPM6A,TNIK,NTRK2
3.538e-02	-3.34	DNA-binding transcription repressor activity	molecular function	GO:0001217	272	3	18094	48	GLIS3,ZBTB20,TRPS1
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	MB (myoglobin)	protein interactions	4151	14	1	19454	50	MAML2
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	PLXNA4 (plexin A4)	protein interactions	91584	14	1	19454	50	GPM6A
3.540e-02	-3.34	FGF7 (fibroblast growth factor 7)	protein interactions	2252	14	1	19454	50	FGFR3
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	ZBTB20
3.540e-02	-3.34	VSX2 (visual system homeobox 2)	protein interactions	338917	14	1	19454	50	AHCYL2
3.540e-02	-3.34	SYT5 (synaptotagmin 5)	protein interactions	6861	14	1	19454	50	NRXN1
3.540e-02	-3.34	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	50	CST3
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.553e-02	-3.34	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	48	16828	49	CPE,RORA,NTRK2,TRPS1,GPM6A,CDH20,TNIK,NPAS3,PREX2,PCDH9,ITPR2,ABLIM1,SLC1A2,SOX5,NKAIN3,NFIA,NRXN1,NTM,GLUD1,ATP13A4,MACF1,NHSL1,NEBL,MSI2,PTPRZ1,GPC5,MAML2,FMN2,SLC1A3,CTNND2,LSAMP,GLIS3,HIF3A,ZBTB20,PITPNC1,SLC4A4,SFXN5,FGFR3,ATP1A2,PARD3B,BMPR1B,RYR3,DTNA,AHCYL2,PTGDS,FBXL7,LIFR,SPARCL1
3.559e-02	-3.34	side of membrane	cellular component	GO:0098552	715	5	19108	49	LIFR,GPC5,NTM,DTNA,LSAMP
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.574e-02	-3.33	human chr10q23.2	chromosome location	human chr10q23.2	19	1	26134	50	GLUD1
3.575e-02	-3.33	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	49	BMPR1B,NTRK2,LIFR,PTPRZ1,TNIK,FGFR3
3.575e-02	-3.33	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	49	NTRK2,TNIK,FGFR3,PTPRZ1,LIFR,BMPR1B
3.586e-02	-3.33	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	2	19454	50	MACF1,SPARCL1
3.590e-02	-3.33	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	44	CTNNA2
3.593e-02	-3.33	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	6	16828	49	GLIS3,HIF3A,FMN2,NFIA,PCDH9,PREX2
3.606e-02	-3.32	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	29	ITPR2
3.606e-02	-3.32	FGFR3c ligand binding and activation	REACTOME pathways	R-HSA-190372	13	1	10285	29	FGFR3
3.606e-02	-3.32	Phospholipase C-mediated cascade; FGFR3	REACTOME pathways	R-HSA-5654227	13	1	10285	29	FGFR3
3.606e-02	-3.32	FGFR3 ligand binding and activation	REACTOME pathways	R-HSA-190239	13	1	10285	29	FGFR3
3.606e-02	-3.32	NOTCH2 intracellular domain regulates transcription	REACTOME pathways	R-HSA-2197563	13	1	10285	29	MAML2
3.606e-02	-3.32	Notch-HLH transcription pathway	REACTOME pathways	R-HSA-350054	13	1	10285	29	MAML2
3.612e-02	-3.32	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	49	BMPR1B,FGFR3,NTRK2,TNIK
3.612e-02	-3.32	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	49	NTRK2,FGFR3,TNIK,BMPR1B
3.612e-02	-3.32	postsynapse organization	biological process	GO:0099173	109	2	18204	50	CTNND2,NRXN1
3.617e-02	-3.32	small_intestine	COSMIC cancer mutations	small_intestine	250	3	16828	49	MACF1,TNIK,FGFR3
3.621e-02	-3.32	regulation of nervous system development	biological process	GO:0051960	456	4	18204	50	NTRK2,MACF1,PTPRZ1,NRXN1
3.630e-02	-3.32	positive regulation of biological process	biological process	GO:0048518	6326	24	18204	50	PTPRZ1,NFIA,MACF1,SLC4A4,GLUD1,NPAS3,RORA,MAML2,FGFR3,GLIS3,NTRK2,SOX5,BMPR1B,ZBTB20,SLC1A2,TNIK,FMN2,SFXN5,ATP1A2,GPM6A,LIFR,NRXN1,SLC1A3,GPC5
3.635e-02	-3.31	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	6	19454	50	PARD3B,MACF1,PITPNC1,FGFR3,NHSL1,ABLIM1
3.642e-02	-3.31	ELK3 (ETS transcription factor ELK3)	protein interactions	2004	117	2	19454	50	NFIA,TRPS1
3.642e-02	-3.31	SYT6 (synaptotagmin 6)	protein interactions	148281	117	2	19454	50	AHCYL2,NRXN1
3.646e-02	-3.31	FOLN	smart domains	SM00274	9	1	9717	40	SPARCL1
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	PITPNC1,ITPR2,PARD3B
3.672e-02	-3.30	positive regulation of cell junction assembly	biological process	GO:1901890	110	2	18204	50	NTRK2,NRXN1
3.678e-02	-3.30	bHLH_dom	interpro domains	IPR011598	112	2	18521	50	NPAS3,HIF3A
3.678e-02	-3.30	HLH_DNA-bd_sf	interpro domains	IPR036638	112	2	18521	50	HIF3A,NPAS3
3.699e-02	-3.30	PLCD3 (phospholipase C delta 3)	protein interactions	113026	118	2	19454	50	AHCYL2,TNIK
3.715e-02	-3.29	Neurexin-like	interpro domains	IPR003585	14	1	18521	50	NRXN1
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	cervix-carcinoma-adenocarcinoma	COSMIC cancer mutations	cervix-carcinoma-adenocarcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	skin-back-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-back-carcinoma-basal_cell_carcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	endometrium-ovary-endometriosis	COSMIC cancer mutations	endometrium-ovary-endometriosis	13	1	16828	49	FGFR3
3.721e-02	-3.29	Brenner_tumour	COSMIC cancer mutations	Brenner_tumour	13	1	16828	49	FGFR3
3.745e-02	-3.28	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	3	19454	50	DTNA,PARD3B,NTRK2
3.745e-02	-3.28	DHFR2 (dihydrofolate reductase 2)	protein interactions	200895	287	3	19454	50	ITPR2,SLC1A3,CPE
3.764e-02	-3.28	Ion_trans	pfam domains	PF00520	109	2	17795	50	ITPR2,RYR3
3.771e-02	-3.28	protein localization to membrane	biological process	GO:0072657	462	4	18204	50	CPE,TNIK,MACF1,NRXN1
3.777e-02	-3.28	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	3	19454	50	NEBL,FMN2,NHSL1
3.779e-02	-3.28	NEDD4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	4734	494	4	19454	50	MAML2,GLIS3,TNIK,FGFR3
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	cellular response to ethanol	biological process	GO:0071361	14	1	18204	50	ITPR2
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	50	TNIK
3.788e-02	-3.27	FGF9 (fibroblast growth factor 9)	protein interactions	2254	15	1	19454	50	FGFR3
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	TESPA1 (thymocyte expressed, positive selection associated 1)	protein interactions	9840	15	1	19454	50	ITPR2
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CPE
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.794e-02	-3.27	rhythmic process	biological process	GO:0048511	270	3	18204	50	NTRK2,RORA,BMPR1B
3.796e-02	-3.27	regulation of membrane potential	biological process	GO:0042391	463	4	18204	50	SLC4A4,NRXN1,ATP1A2,NTRK2
3.798e-02	-3.27	Cadherin-like_dom	interpro domains	IPR002126	114	2	18521	50	CDH20,PCDH9
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	NEBL,GLUD1,ABLIM1
3.814e-02	-3.27	HOXB9 (homeobox B9)	protein interactions	3219	120	2	19454	50	NFIA,AHCYL2
3.829e-02	-3.26	carboxylic acid biosynthetic process	biological process	GO:0046394	271	3	18204	50	SLC1A3,GLUD1,PTGDS
3.851e-02	-3.26	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	49	BMPR1B,NTRK2,TNIK,FGFR3
3.864e-02	-3.25	GATA	pfam domains	PF00320	14	1	17795	50	TRPS1
3.873e-02	-3.25	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	50	NTRK2,TNIK,CTNNA2,MACF1,GPM6A
3.878e-02	-3.25	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	29	ABLIM1
3.902e-02	-3.24	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	44	TRPS1
3.902e-02	-3.24	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	44	NTRK2
3.902e-02	-3.24	LIPOCALIN	prosite domains	PS00213	11	1	12186	44	PTGDS
3.908e-02	-3.24	neurexin family protein binding	molecular function	GO:0042043	15	1	18094	48	CPE
3.908e-02	-3.24	tropomyosin binding	molecular function	GO:0005523	15	1	18094	48	NEBL
3.908e-02	-3.24	filamin binding	molecular function	GO:0031005	15	1	18094	48	NEBL
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.918e-02	-3.24	regulation of circadian rhythm	biological process	GO:0042752	114	2	18204	50	PTGDS,RORA
3.918e-02	-3.24	negative regulation of protein catabolic process	biological process	GO:0042177	114	2	18204	50	FMN2,CST3
3.920e-02	-3.24	Cadherin-like_sf	interpro domains	IPR015919	116	2	18521	50	CDH20,PCDH9
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	NHSL1,DTNA
3.936e-02	-3.24	organic acid biosynthetic process	biological process	GO:0016053	274	3	18204	50	PTGDS,GLUD1,SLC1A3
3.943e-02	-3.23	human chr4q32.3	chromosome location	human chr4q32.3	21	1	26134	50	CPE
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.943e-02	-3.23	cell migration	biological process	GO:0016477	921	6	18204	50	GPC5,GPM6A,CTNNA2,NTRK2,CDH20,FMN2
3.947e-02	-3.23	pulmonary_blastoma	COSMIC cancer mutations	pulmonary_blastoma	648	5	16828	49	NTM,TRPS1,BMPR1B,NEBL,ATP13A4
3.947e-02	-3.23	pleura-pulmonary_blastoma	COSMIC cancer mutations	pleura-pulmonary_blastoma	648	5	16828	49	TRPS1,NTM,NEBL,BMPR1B,ATP13A4
3.954e-02	-3.23	Cadherin	pfam domains	PF00028	112	2	17795	50	PCDH9,CDH20
3.959e-02	-3.23	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	5	RORA
3.959e-02	-3.23	Ammonia Recycling	SMPDB pathways	SMP0000009	11	1	1369	5	GLUD1
3.967e-02	-3.23	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	46	16828	49	BMPR1B,RYR3,DTNA,LIFR,SPARCL1,AHCYL2,FBXL7,PTPRZ1,CTNND2,SLC1A3,FMN2,GPC5,MAML2,NEBL,SFXN5,PITPNC1,SLC4A4,ATP1A2,PARD3B,FGFR3,HIF3A,GLIS3,LSAMP,ZBTB20,NRXN1,SLC1A2,SOX5,NKAIN3,NFIA,MACF1,NHSL1,GLUD1,NTM,ATP13A4,CDH20,TRPS1,GPM6A,TNIK,CPE,RORA,NTRK2,ITPR2,ABLIM1,PCDH9,PREX2,NPAS3
3.970e-02	-3.23	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	5	16828	49	MACF1,ABLIM1,FGFR3,TNIK,PREX2
3.971e-02	-3.23	gliogenesis	biological process	GO:0042063	275	3	18204	50	NTRK2,NFIA,PTPRZ1
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.988e-02	-3.22	PAX7 (paired box 7)	protein interactions	5081	123	2	19454	50	NFIA,TRPS1
4.002e-02	-3.22	endometriosis	COSMIC cancer mutations	endometriosis	14	1	16828	49	FGFR3
4.002e-02	-3.22	soft_tissue-small_round_cell_tumour	COSMIC cancer mutations	soft_tissue-small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	in_situ_neoplasm	COSMIC cancer mutations	in_situ_neoplasm	14	1	16828	49	FGFR3
4.002e-02	-3.22	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	14	1	16828	49	FGFR3
4.002e-02	-3.22	small_round_cell_tumour	COSMIC cancer mutations	small_round_cell_tumour	14	1	16828	49	FGFR3
4.008e-02	-3.22	telencephalon development	biological process	GO:0021537	276	3	18204	50	SLC1A2,ATP1A2,NTRK2
4.008e-02	-3.22	transcription cis-regulatory region binding	molecular function	GO:0000976	1485	8	18094	48	ZBTB20,TRPS1,HIF3A,SOX5,NPAS3,RORA,NFIA,GLIS3
4.015e-02	-3.22	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	18	16828	49	MACF1,NHSL1,PARD3B,SPARCL1,FGFR3,GLIS3,PREX2,NPAS3,CDH20,PTPRZ1,TRPS1,SLC1A3,CTNND2,FMN2,MAML2,RYR3,RORA,NFIA
4.023e-02	-3.21	Prot_kinase_dom	interpro domains	IPR000719	480	4	18521	50	BMPR1B,TNIK,NTRK2,FGFR3
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.035e-02	-3.21	transcription regulatory region nucleic acid binding	molecular function	GO:0001067	1487	8	18094	48	NFIA,GLIS3,RORA,HIF3A,NPAS3,SOX5,ZBTB20,TRPS1
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	Sumo3 (small ubiquitin-like modifier 3)	protein interactions	20610	16	1	19454	50	ITPR2
4.035e-02	-3.21	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	50	NRXN1
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	CTSK (cathepsin K)	protein interactions	1513	16	1	19454	50	FGFR3
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	HLA-H (major histocompatibility complex, class I, H (pseudogene))	protein interactions	3136	16	1	19454	50	FGFR3
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	CNTFR (ciliary neurotrophic factor receptor)	protein interactions	1271	16	1	19454	50	LIFR
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	50	NRXN1
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	SYT4 (synaptotagmin 4)	protein interactions	6860	16	1	19454	50	NRXN1
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	50	RORA
4.043e-02	-3.21	chondrocyte proliferation	biological process	GO:0035988	15	1	18204	50	FGFR3
4.043e-02	-3.21	exit from mitosis	biological process	GO:0010458	15	1	18204	50	NFIA
4.043e-02	-3.21	regulation of circadian sleep/wake cycle, sleep	biological process	GO:0045187	15	1	18204	50	PTGDS
4.043e-02	-3.21	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	50	NTRK2
4.043e-02	-3.21	synapse maturation	biological process	GO:0060074	15	1	18204	50	NFIA
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	50	MACF1
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	50	NTRK2
4.065e-02	-3.20	membrane protein complex	cellular component	GO:0098796	1261	7	19108	49	SLC1A2,CDH20,ATP1A2,BMPR1B,CTNNA2,SLC1A3,RYR3
4.081e-02	-3.20	Circadian rythm related genes	WikiPathways	WP3594	207	3	5310	20	PTGDS,CST3,RORA
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	FGFR3,NTRK2,LSAMP,NTM
4.106e-02	-3.19	SLAMF1 (signaling lymphocytic activation molecule family member 1)	protein interactions	6504	125	2	19454	50	CPE,LIFR
4.106e-02	-3.19	SCGB1D1 (secretoglobin family 1D member 1)	protein interactions	10648	125	2	19454	50	CPE,LIFR
4.107e-02	-3.19	regulation of synapse assembly	biological process	GO:0051963	117	2	18204	50	NTRK2,NRXN1
4.117e-02	-3.19	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	48	SLC4A4,SLC1A2,SLC1A3
4.128e-02	-3.19	positive regulation of cellular process	biological process	GO:0048522	5719	22	18204	50	FGFR3,GLIS3,PTPRZ1,NTRK2,SOX5,BMPR1B,ZBTB20,NFIA,TNIK,SLC1A2,MACF1,SLC4A4,FMN2,GLUD1,GPM6A,LIFR,NPAS3,NRXN1,RORA,MAML2,SLC1A3,GPC5
4.134e-02	-3.19	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	50	ATP1A2
4.134e-02	-3.19	CNH	pfam domains	PF00780	15	1	17795	50	TNIK
4.134e-02	-3.19	FH2	pfam domains	PF02181	15	1	17795	50	FMN2
4.150e-02	-3.18	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME pathways	R-HSA-2162123	15	1	10285	29	PTGDS
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	GPM6A,PITPNC1
4.168e-02	-3.18	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	5	18204	50	NTRK2,TNIK,FGFR3,SLC4A4,ZBTB20
4.168e-02	-3.18	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	5	18204	50	NTRK2,TNIK,SLC4A4,FGFR3,ZBTB20
4.170e-02	-3.18	synapse assembly	biological process	GO:0007416	118	2	18204	50	GPM6A,NRXN1
4.171e-02	-3.18	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	7	16828	49	ATP13A4,RYR3,SOX5,SLC1A2,FMN2,GPC5,CDH20
4.193e-02	-3.17	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	50	MAML2,TNIK,LIFR,NFIA,CPE,NTRK2,BMPR1B,MACF1,FGFR3,CTNND2
4.193e-02	-3.17	response to stimulus	biological process	GO:0050896	7803	28	18204	50	SPARCL1,CTNND2,DTNA,CTNNA2,PITPNC1,NFIA,MACF1,RORA,PTGDS,MAML2,ITPR2,SOX5,NTRK2,BMPR1B,FGFR3,TNIK,SLC1A2,ZBTB20,CPE,ATP1A2,FMN2,PREX2,CST3,RYR3,SLC1A3,LIFR,GPM6A,NRXN1
4.208e-02	-3.17	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	19	16828	49	SOX5,BMPR1B,RORA,MSI2,NTRK2,PTPRZ1,TRPS1,CTNND2,TNIK,MAML2,FMN2,HIF3A,PREX2,ATP13A4,FBXL7,ITPR2,PITPNC1,LIFR,FGFR3
4.225e-02	-3.16	EF_HAND_2	prosite domains	PS50222	215	3	12186	44	RYR3,MACF1,SPARCL1
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	TRPS1,NFIA
4.235e-02	-3.16	CarboxyPept-like_regulatory	interpro domains	IPR008969	16	1	18521	50	CPE
4.267e-02	-3.15	neuron projection terminus	cellular component	GO:0044306	128	2	19108	49	SLC1A2,NTRK2
4.268e-02	-3.15	TyrKc	smart domains	SM00219	80	2	9717	40	FGFR3,NTRK2
4.282e-02	-3.15	ureter	COSMIC cancer mutations	ureter	15	1	16828	49	FGFR3
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	NOTCH4 (notch receptor 4)	protein interactions	4855	17	1	19454	50	MAML2
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.286e-02	-3.15	SYT2 (synaptotagmin 2)	protein interactions	127833	128	2	19454	50	NRXN1,AHCYL2
4.286e-02	-3.15	MYB (MYB proto-oncogene, transcription factor)	protein interactions	4602	128	2	19454	50	NFIA,TRPS1
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	MACF1,SOX5
4.286e-02	-3.15	TEAD2 (TEA domain transcription factor 2)	protein interactions	8463	128	2	19454	50	TRPS1,ZBTB20
4.297e-02	-3.15	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	6	19454	50	AHCYL2,DTNA,PREX2,FMN2,MACF1,SLC1A3
4.307e-02	-3.14	asymmetric cell division	biological process	GO:0008356	16	1	18204	50	SOX5
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.307e-02	-3.14	neuron cell-cell adhesion	biological process	GO:0007158	16	1	18204	50	NRXN1
4.307e-02	-3.14	tricarboxylic acid metabolic process	biological process	GO:0072350	16	1	18204	50	GLUD1
4.307e-02	-3.14	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	50	SLC1A3
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	S-adenosylmethionine metabolic process	biological process	GO:0046500	16	1	18204	50	AHCYL2
4.307e-02	-3.14	insulin metabolic process	biological process	GO:1901142	16	1	18204	50	CPE
4.307e-02	-3.14	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	50	ATP1A2
4.307e-02	-3.14	glutamine family amino acid biosynthetic process	biological process	GO:0009084	16	1	18204	50	GLUD1
4.307e-02	-3.14	cardiac left ventricle morphogenesis	biological process	GO:0003214	16	1	18204	50	CPE
4.313e-02	-3.14	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	5	ATP1A2
4.313e-02	-3.14	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	5	ATP1A2
4.318e-02	-3.14	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	23	SLC4A4
4.329e-02	-3.14	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	49	TNIK,NTRK2,FGFR3,BMPR1B
4.340e-02	-3.14	cell junction assembly	biological process	GO:0034329	285	3	18204	50	GPM6A,CDH20,NRXN1
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	SOX5,ZBTB20
4.346e-02	-3.14	POLA2 (DNA polymerase alpha 2, accessory subunit)	protein interactions	23649	129	2	19454	50	CPE,FGFR3
4.388e-02	-3.13	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	49	BMPR1B,NTRK2,FGFR3,TNIK
4.388e-02	-3.13	Z disc	cellular component	GO:0030018	130	2	19108	49	NEBL,RYR3
4.417e-02	-3.12	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	48	PTPRZ1
4.417e-02	-3.12	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	48	PTPRZ1
4.432e-02	-3.12	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	20	RYR3
4.432e-02	-3.12	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	20	BMPR1B
4.432e-02	-3.12	endomembrane system	cellular component	GO:0012505	4764	18	19108	49	MACF1,FGFR3,CPE,NTRK2,SPARCL1,ATP1A2,CST3,PTGDS,GLUD1,GPC5,AHCYL2,FMN2,ATP13A4,TNIK,ITPR2,PARD3B,NRXN1,RYR3
4.467e-02	-3.11	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	44	FMN2
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	SOX5,NFIA
4.468e-02	-3.11	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	50	RORA,NFIA
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	SOX5,NFIA
4.477e-02	-3.11	Helix-loop-helix DNA-binding domain	gene3d domains	4.10.280.10	111	2	14470	44	NPAS3,HIF3A
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	PAC	interpro domains	IPR001610	17	1	18521	50	HIF3A
4.493e-02	-3.10	Cystatin_dom	interpro domains	IPR000010	17	1	18521	50	CST3
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.499e-02	-3.10	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	3	19454	50	DTNA,NRXN1,MACF1
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	GLIS3,LSAMP,HIF3A,ZBTB20,CST3,PITPNC1,SLC4A4,SFXN5,FGFR3,ATP1A2,PARD3B,NEBL,MSI2,PTPRZ1,FMN2,MAML2,GPC5,CTNND2,SLC1A3,AHCYL2,PTGDS,FBXL7,LIFR,SPARCL1,BMPR1B,RYR3,DTNA,NPAS3,PREX2,PCDH9,ITPR2,ABLIM1,CPE,RORA,NTRK2,TRPS1,GPM6A,CDH20,TNIK,NTM,GLUD1,ATP13A4,MACF1,NHSL1,SLC1A2,SOX5,NFIA,NKAIN3,NRXN1
4.517e-02	-3.10	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	44	FGFR3,NTRK2
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	FGFR3
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	PTGFR (prostaglandin F receptor)	protein interactions	5737	18	1	19454	50	PTGDS
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.530e-02	-3.09	GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1)	protein interactions	338328	132	2	19454	50	FGFR3,CPE
4.560e-02	-3.09	action potential	biological process	GO:0001508	124	2	18204	50	NTRK2,ATP1A2
4.561e-02	-3.09	renal_pelvis	COSMIC cancer mutations	renal_pelvis	16	1	16828	49	FGFR3
4.561e-02	-3.09	normal	COSMIC cancer mutations	normal	16	1	16828	49	FGFR3
4.561e-02	-3.09	flank	COSMIC cancer mutations	flank	16	1	16828	49	FGFR3
4.561e-02	-3.09	urinary_tract-carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma	16	1	16828	49	FGFR3
4.565e-02	-3.09	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	49	BMPR1B,FGFR3,NTRK2,TNIK
4.570e-02	-3.09	cGMP metabolic process	biological process	GO:0046068	17	1	18204	50	RORA
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	50	CTNNA2
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	TNIK
4.570e-02	-3.09	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	50	RORA
4.570e-02	-3.09	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	50	ATP1A2
4.570e-02	-3.09	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	50	NTRK2
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	viral genome replication	biological process	GO:0019079	17	1	18204	50	NFIA
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	ureter development	biological process	GO:0072189	17	1	18204	50	NFIA
4.596e-02	-3.08	CARBOXYPEPT_ZN_2	prosite domains	PS00133	13	1	12186	44	CPE
4.596e-02	-3.08	CARBOXYPEPT_ZN_1	prosite domains	PS00132	13	1	12186	44	CPE
4.607e-02	-3.08	response to hypoxia	biological process	GO:0001666	292	3	18204	50	RORA,ITPR2,FMN2
4.613e-02	-3.08	PDZ	pfam domains	PF00595	122	2	17795	50	PARD3B,PREX2
4.615e-02	-3.08	cell cortex	cellular component	GO:0005938	313	3	19108	49	PARD3B,FMN2,ITPR2
4.629e-02	-3.07	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	Pathway Interaction DB	hif1apathway	15	1	2226	7	HIF3A
4.631e-02	-3.07	modulation of chemical synaptic transmission	biological process	GO:0050804	494	4	18204	50	ATP1A2,NTRK2,SLC1A3,NRXN1
4.636e-02	-3.07	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	4	12186	44	BMPR1B,TNIK,FGFR3,NTRK2
4.660e-02	-3.07	regulation of trans-synaptic signaling	biological process	GO:0099177	495	4	18204	50	NRXN1,SLC1A3,ATP1A2,NTRK2
4.665e-02	-3.07	Argininemia	SMPDB pathways	SMP0000357	13	1	1369	5	GLUD1
4.665e-02	-3.07	Citrullinemia Type I	SMPDB pathways	SMP0000001	13	1	1369	5	GLUD1
4.665e-02	-3.07	Ornithine Transcarbamylase Deficiency (OTC Deficiency)	SMPDB pathways	SMP0000205	13	1	1369	5	GLUD1
4.665e-02	-3.07	Carbamoyl Phosphate Synthetase Deficiency	SMPDB pathways	SMP0000002	13	1	1369	5	GLUD1
4.665e-02	-3.07	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	5	ATP1A2
4.665e-02	-3.07	Urea Cycle	SMPDB pathways	SMP0000059	13	1	1369	5	GLUD1
4.665e-02	-3.07	Argininosuccinic Aciduria	SMPDB pathways	SMP0000003	13	1	1369	5	GLUD1
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.671e-02	-3.06	NAD+ binding	molecular function	GO:0070403	18	1	18094	48	GLUD1
4.673e-02	-3.06	Carb_anhydrase	pfam domains	PF00194	17	1	17795	50	PTPRZ1
4.673e-02	-3.06	ZZ	pfam domains	PF00569	17	1	17795	50	DTNA
4.673e-02	-3.06	Cystatin	pfam domains	PF00031	17	1	17795	50	CST3
4.690e-02	-3.06	Elevation of cytosolic Ca2+ levels	REACTOME pathways	R-HSA-139853	17	1	10285	29	ITPR2
4.696e-02	-3.06	Cadherins	gene3d domains	2.60.40.60	114	2	14470	44	CDH20,PCDH9
4.716e-02	-3.05	FOXP1 (forkhead box P1)	protein interactions	27086	135	2	19454	50	SOX5,NFIA
4.716e-02	-3.05	SOX15 (SRY-box transcription factor 15)	protein interactions	6665	135	2	19454	50	TRPS1,NFIA
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	HIF3A,GLIS3,LSAMP,ZBTB20,CST3,SFXN5,PITPNC1,SLC4A4,ATP1A2,PARD3B,FGFR3,NEBL,MSI2,PTPRZ1,SLC1A3,CTNND2,MAML2,FMN2,GPC5,AHCYL2,FBXL7,PTGDS,LIFR,SPARCL1,BMPR1B,RYR3,DTNA,PCDH9,PREX2,NPAS3,ITPR2,ABLIM1,CPE,RORA,NTRK2,CDH20,TRPS1,GPM6A,TNIK,GLUD1,NTM,ATP13A4,MACF1,NHSL1,SLC1A2,SOX5,NKAIN3,NFIA,NRXN1
4.728e-02	-3.05	localization	biological process	GO:0051179	4474	18	18204	50	PITPNC1,PARD3B,SLC1A2,TNIK,NTRK2,ITPR2,GPM6A,NRXN1,ATP13A4,PTGDS,SLC1A3,RYR3,SLC4A4,MACF1,FMN2,CPE,SFXN5,ATP1A2
4.743e-02	-3.05	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	18	16828	49	NFIA,RORA,RYR3,MAML2,FMN2,SLC1A3,CTNND2,TRPS1,PTPRZ1,CDH20,NPAS3,PREX2,GLIS3,FGFR3,SPARCL1,NHSL1,PARD3B,MACF1
4.752e-02	-3.05	Leu-rich_rpt_Cys-con_subtyp	interpro domains	IPR006553	18	1	18521	50	FBXL7
4.754e-02	-3.05	ZYX (zyxin)	protein interactions	7791	316	3	19454	50	MACF1,NEBL,ABLIM1
4.760e-02	-3.05	response to amino acid	biological process	GO:0043200	127	2	18204	50	SLC1A2,NTRK2
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	TNIK,CTNND2,NTRK2
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.764e-02	-3.04	astrocyte projection	cellular component	GO:0097449	19	1	19108	49	SLC1A2
4.772e-02	-3.04	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	49	CTNND2,FMN2
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	LIFR
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	50	NRXN1
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	NLGN1 (neuroligin 1)	protein interactions	22871	19	1	19454	50	NRXN1
4.785e-02	-3.04	anion binding	molecular function	GO:0043168	2412	11	18094	48	ATP13A4,GLUD1,FGFR3,TNIK,ITPR2,ATP1A2,SLC1A3,PITPNC1,BMPR1B,NTRK2,PTGDS
4.793e-02	-3.04	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	1	5310	20	RYR3
4.793e-02	-3.04	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	3	16828	49	TNIK,ATP1A2,PREX2
4.804e-02	-3.04	muscle system process	biological process	GO:0003012	297	3	18204	50	RYR3,DTNA,ATP1A2
4.832e-02	-3.03	DWA	smart domains	SM00523	12	1	9717	40	NFIA
4.832e-02	-3.03	ZnF_GATA	smart domains	SM00401	12	1	9717	40	TRPS1
4.832e-02	-3.03	dicarboxylic acid catabolic process	biological process	GO:0043649	18	1	18204	50	GLUD1
4.832e-02	-3.03	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	50	NTRK2
4.832e-02	-3.03	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	50	RORA
4.832e-02	-3.03	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	50	NEBL
4.832e-02	-3.03	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	50	CST3
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.839e-02	-3.03	non_chronically_sun_exposed_site	COSMIC cancer mutations	non_chronically_sun_exposed_site	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-non_chronically_sun_exposed_site-malignant_melanoma	COSMIC cancer mutations	skin-non_chronically_sun_exposed_site-malignant_melanoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	breast-carcinoma-neuroendocrine_carcinoma	COSMIC cancer mutations	breast-carcinoma-neuroendocrine_carcinoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-other-verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	skin-other-verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.842e-02	-3.03	Bmpr1a (bone morphogenetic protein receptor, type 1A)	protein interactions	12166	137	2	19454	50	LIFR,GLUD1
4.842e-02	-3.03	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	2	19454	50	NFIA,SOX5
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.893e-02	-3.02	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	37	16828	49	ITPR2,SFXN5,ABLIM1,FGFR3,ATP1A2,LSAMP,NPAS3,ZBTB20,PREX2,PCDH9,GPM6A,PTPRZ1,TRPS1,CDH20,FMN2,TNIK,MAML2,GPC5,SLC1A3,CTNND2,RORA,CPE,NEBL,NTRK2,MACF1,SPARCL1,NHSL1,AHCYL2,GLUD1,FBXL7,ATP13A4,NRXN1,SOX5,RYR3,SLC1A2,NKAIN3,DTNA
4.894e-02	-3.02	response to organophosphorus	biological process	GO:0046683	129	2	18204	50	RYR3,ITPR2
4.911e-02	-3.01	sequence-specific double-stranded DNA binding	molecular function	GO:1990837	1547	8	18094	48	HIF3A,NPAS3,SOX5,TRPS1,ZBTB20,NFIA,GLIS3,RORA
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.931e-02	-3.01	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	18	19454	50	PITPNC1,ATP1A2,GLUD1,MSI2,TNIK,PTPRZ1,CTNND2,MACF1,CTNNA2,CST3,SLC1A3,GPM6A,NTM,ITPR2,DTNA,SLC4A4,LSAMP,AHCYL2
4.951e-02	-3.01	cellular response to organonitrogen compound	biological process	GO:0071417	505	4	18204	50	ITPR2,SLC1A3,RYR3,SLC1A2
4.960e-02	-3.00	PI-3K cascade:FGFR3	REACTOME pathways	R-HSA-5654710	18	1	10285	29	FGFR3
4.960e-02	-3.00	SHC-mediated cascade:FGFR3	REACTOME pathways	R-HSA-5654704	18	1	10285	29	FGFR3
4.987e-02	-3.00	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	2	18094	48	RYR3,ITPR2