Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
8.718e-14	-30.07	nervous system development	biological process	GO:0007399	2185	28	18204	50	CNTN1,NTM,LSAMP,NTRK2,PLCB1,CTNND2,GPM6A,PRKG1,CTNNA2,CAMK2G,DCLK2,PARD3,SOX5,NAV2,ATP1A2,RORA,NRG3,ERBB4,TNC,RFX4,APOE,TNIK,DGKG,SLC1A2,MSI2,CLU,GFAP,NRXN1
9.732e-11	-23.05	neurogenesis	biological process	GO:0022008	1334	20	18204	50	GFAP,RORA,NAV2,CLU,NRXN1,CTNNA2,PRKG1,CTNND2,GPM6A,PARD3,SOX5,DCLK2,APOE,NTM,NTRK2,TNIK,DGKG,TNC,ERBB4,CNTN1
1.526e-10	-22.60	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	19	16828	48	LSAMP,NKAIN3,NTRK2,SOX5,SLC1A2,HPSE2,DCLK2,NAV2,ERBB4,NRG3,PRKG1,LRP1B,TNIK,PARD3,NPAS3,RYR3,CAMK2G,ATP1A2,ADCY2
1.526e-10	-22.60	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	19	16828	48	ADCY2,ATP1A2,NPAS3,RYR3,CAMK2G,PRKG1,LRP1B,TNIK,PARD3,NRG3,DCLK2,ERBB4,NAV2,HPSE2,LSAMP,NTRK2,NKAIN3,SLC1A2,SOX5
1.611e-10	-22.55	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	16	16828	48	RYR3,GPC5,PARD3,PLCB1,LRP1B,ADCY2,ATP1A2,HPSE2,SLC1A2,SOX5,NTRK2,NKAIN3,LSAMP,NRG3,NAV2,ERBB4
6.566e-10	-21.14	generation of neurons	biological process	GO:0048699	1158	18	18204	50	PARD3,SOX5,DCLK2,PRKG1,CTNNA2,GPM6A,CTNND2,NRXN1,RORA,GFAP,TNC,ERBB4,CNTN1,NTM,DGKG,TNIK,NTRK2,APOE
1.689e-09	-20.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	20	16828	48	LSAMP,RORA,NTRK2,NKAIN3,SOX5,HPSE2,DGKG,ERBB4,NAV2,NRG3,PRKG1,LRP1B,PLCB1,FMN2,PARD3,CTNND2,GPC5,RYR3,NEBL,ADCY2
1.689e-09	-20.20	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	20	16828	48	NEBL,ADCY2,PARD3,FMN2,PLCB1,LRP1B,PRKG1,RYR3,GPC5,CTNND2,ERBB4,NAV2,DGKG,NRG3,SOX5,NTRK2,NKAIN3,RORA,LSAMP,HPSE2
1.832e-09	-20.12	system development	biological process	GO:0048731	3533	29	18204	50	PLCB1,NTM,LSAMP,NTRK2,NEBL,CNTN1,NRG3,ATP1A2,RORA,NAV2,SOX5,PARD3,CAMK2G,DCLK2,PRKG1,CTNNA2,CTNND2,GPM6A,SLC1A2,DGKG,TNIK,RFX4,APOE,TNC,ERBB4,NRXN1,GFAP,CLU,MSI2
1.844e-09	-20.11	cerebellum	COSMIC cancer mutations	cerebellum	769	15	16828	48	PARD3,PLCB1,LRP1B,PRKG1,RYR3,NPAS3,GPC5,CTNND2,NEBL,NTRK2,ABLIM1,NRXN1,HPSE2,ERBB4,NRG3
1.910e-09	-20.08	neuron differentiation	biological process	GO:0030182	1081	17	18204	50	APOE,NTM,TNIK,DGKG,NTRK2,TNC,ERBB4,CNTN1,GFAP,RORA,NRXN1,PRKG1,CTNNA2,CTNND2,GPM6A,PARD3,DCLK2
1.996e-09	-20.03	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	13	16828	48	ADCY2,GPC5,CTNND2,RYR3,LRP1B,PRKG1,PLCB1,GPM6A,FMN2,NRG3,LSAMP,SOX5,NKAIN3
2.172e-09	-19.95	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	14	16828	48	ERBB4,NRG3,NTRK2,ABLIM1,NRXN1,HPSE2,NEBL,PARD3,PLCB1,LRP1B,PRKG1,RYR3,NPAS3,CTNND2
2.215e-09	-19.93	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	14	16828	48	ABLIM1,NTRK2,HPSE2,NRXN1,ERBB4,NRG3,LRP1B,PRKG1,PARD3,PLCB1,NPAS3,CTNND2,RYR3,NEBL
2.339e-09	-19.87	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	23	16828	48	PLCB1,GPM6A,FMN2,LRP1B,RYR3,NKAIN3,NTRK2,SLC1A2,CNTN1,DGKG,ERBB4,NAV2,PARD3,PRKG1,CTNND2,GPC5,NPAS3,ADCY2,SOX5,LSAMP,HPSE2,NRG3,RFX4
2.339e-09	-19.87	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	23	16828	48	RYR3,LRP1B,GPM6A,FMN2,PLCB1,CNTN1,SLC1A2,NKAIN3,NTRK2,ERBB4,DGKG,NAV2,NPAS3,CTNND2,GPC5,PRKG1,PARD3,ADCY2,HPSE2,LSAMP,SOX5,RFX4,NRG3
4.712e-09	-19.17	cell periphery	cellular component	GO:0071944	6020	36	19108	50	NRG3,CLU,MAPK10,RYR3,SORBS1,NKAIN3,TRPM3,CTNNA2,NRXN1,CTNND2,HPSE2,GPC5,LRP1B,APOE,DGKG,DTNA,CNTN1,LSAMP,NTM,FMN2,CST3,ERBB4,TNC,ATP1A2,PARD3,ADCY2,CDH20,TNIK,SLC1A2,NTRK2,SLC4A4,PRKG1,MACF1,SLC14A1,NAV2,GPM6A
4.778e-09	-19.16	central nervous system development	biological process	GO:0007417	995	16	18204	50	PLCB1,SLC1A2,NTRK2,RFX4,CNTN1,ERBB4,NRG3,RORA,GFAP,ATP1A2,CLU,NAV2,DCLK2,CTNNA2,PRKG1,MSI2
5.243e-09	-19.07	multicellular organism development	biological process	GO:0007275	3957	30	18204	50	CDH20,MSI2,GFAP,CLU,NRXN1,TNC,ERBB4,APOE,RFX4,SLC1A2,TNIK,DGKG,PRKG1,CTNNA2,GPM6A,CTNND2,PARD3,SOX5,DCLK2,CAMK2G,ATP1A2,RORA,NAV2,NRG3,CNTN1,NEBL,PLCB1,NTRK2,LSAMP,NTM
5.425e-09	-19.03	neuron development	biological process	GO:0048666	859	15	18204	50	NRXN1,GFAP,DCLK2,PARD3,GPM6A,CTNND2,CTNNA2,PRKG1,NTM,DGKG,TNIK,NTRK2,APOE,CNTN1,TNC
6.314e-09	-18.88	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	12	16828	48	LSAMP,TRPM3,NAV2,ERBB4,NRG3,PRKG1,LRP1B,PLCB1,GPM6A,GPC5,CTNND2,RYR3
1.088e-08	-18.34	mouth	COSMIC cancer mutations	mouth	9004	44	16828	48	DCLK2,CST3,NRG3,RFX4,CLU,LSAMP,ABLIM1,RORA,SLC4A4,SOX5,MACF1,HPSE2,TRPM3,NEBL,CDH20,ADCY2,PRKG1,NTM,PARD3,GPC5,CTNND2,NPAS3,CAMK2G,DTNA,NAV2,ERBB4,DGKG,CNTN1,APOE,NTRK2,TNC,SLC1A2,NRXN1,PITPNC1,ATP1A2,MGAT4C,LRP1B,PLCB1,GPM6A,FMN2,TNIK,SORBS1,GFAP,RYR3
1.676e-08	-17.90	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	39	16828	48	MGAT4C,ATP1A2,PITPNC1,LRP1B,GFAP,PLCB1,FMN2,GPM6A,TNIK,SORBS1,RYR3,ERBB4,NAV2,DGKG,CNTN1,SLC1A2,TNC,NRXN1,NEBL,CDH20,ADCY2,PRKG1,NTM,PARD3,GPC5,CTNND2,DTNA,CAMK2G,DCLK2,CST3,RFX4,NRG3,ABLIM1,RORA,LSAMP,SOX5,SLC4A4,TRPM3,MACF1
2.230e-08	-17.62	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	29	16828	48	NKAIN3,TNC,NTRK2,SLC1A2,CNTN1,NRXN1,NAV2,ERBB4,GLIS3,TNIK,PLCB1,GPM6A,FMN2,LRP1B,RYR3,MGAT4C,SOX5,SLC4A4,LSAMP,RORA,HPSE2,NRG3,NTM,PARD3,PRKG1,CTNND2,GPC5,NEBL,ADCY2
2.230e-08	-17.62	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	29	16828	48	NAV2,ERBB4,GLIS3,NTRK2,NKAIN3,TNC,SLC1A2,CNTN1,NRXN1,MGAT4C,PLCB1,FMN2,GPM6A,TNIK,LRP1B,RYR3,NRG3,SOX5,SLC4A4,LSAMP,RORA,HPSE2,NEBL,ADCY2,NTM,PARD3,PRKG1,CTNND2,GPC5
2.935e-08	-17.34	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	28	16828	48	RORA,CLU,LSAMP,SOX5,HPSE2,MACF1,NRG3,PRKG1,PARD3,GPC5,CTNND2,NEBL,CDH20,ADCY2,CNTN1,SLC1A2,NKAIN3,TNC,NAV2,DGKG,ERBB4,LRP1B,GPM6A,FMN2,TNIK,PLCB1,RYR3,ATP1A2
3.024e-08	-17.31	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	30	16828	48	NRG3,SOX5,RORA,LSAMP,CLU,MACF1,HPSE2,NEBL,ADCY2,CDH20,PARD3,PRKG1,DTNA,GPC5,CTNND2,DGKG,NAV2,ERBB4,SLC1A2,TNC,NTRK2,NKAIN3,CNTN1,ATP1A2,FMN2,PLCB1,TNIK,GPM6A,LRP1B,RYR3
3.501e-08	-17.17	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	35	16828	48	CST3,NRG3,SLC14A1,SLC4A4,SOX5,LSAMP,CLU,MACF1,HPSE2,TRPM3,NEBL,ADCY2,CDH20,NTM,PARD3,PRKG1,DTNA,GPC5,CTNND2,NPAS3,DGKG,NAV2,ERBB4,NTRK2,TNC,NKAIN3,CNTN1,ATP1A2,MGAT4C,SORBS1,PLCB1,FMN2,GPM6A,LRP1B,RYR3
3.501e-08	-17.17	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	35	16828	48	RYR3,LRP1B,FMN2,GPM6A,PLCB1,SORBS1,MGAT4C,ATP1A2,CNTN1,NKAIN3,TNC,NTRK2,ERBB4,NAV2,DGKG,NPAS3,GPC5,CTNND2,DTNA,PRKG1,PARD3,NTM,CDH20,ADCY2,NEBL,TRPM3,MACF1,HPSE2,CLU,LSAMP,SOX5,SLC4A4,NRG3,SLC14A1,CST3
6.243e-08	-16.59	plasma membrane	cellular component	GO:0005886	5538	33	19108	50	NTM,CNTN1,DTNA,LSAMP,DGKG,CST3,FMN2,ATP1A2,ERBB4,CDH20,ADCY2,PARD3,PRKG1,SLC4A4,NTRK2,TNIK,SLC1A2,SLC14A1,MACF1,GPM6A,NRG3,MAPK10,TRPM3,NKAIN3,SORBS1,RYR3,CTNNA2,LRP1B,GPC5,HPSE2,NRXN1,CTNND2,APOE
7.021e-08	-16.47	MAPT (microtubule associated protein tau)	protein interactions	4137	948	14	19454	50	ATP1A2,GPM6A,APOE,ABLIM1,CTNND2,NEBL,TNIK,CLU,MAPK10,LSAMP,SORBS1,CTNNA2,SLC1A2,NTM
7.346e-08	-16.43	lymph_node	COSMIC cancer mutations	lymph_node	1703	19	16828	48	CAMK2G,DTNA,RYR3,CTNND2,GPC5,PARD3,PLCB1,GPM6A,TNIK,LRP1B,PRKG1,NEBL,TRPM3,SOX5,NTRK2,LSAMP,NRG3,ERBB4,NAV2
7.535e-08	-16.40	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	15	19454	50	SLC4A4,APOE,GPM6A,ATP1A2,MSI2,PLCB1,CNTN1,CAMK2G,ABLIM1,TNC,MACF1,TRPM3,CLU,SORBS1,LSAMP
8.476e-08	-16.28	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	43	16828	48	PITPNC1,PLCB1,FMN2,TNIK,GPM6A,SORBS1,LRP1B,RYR3,NAV2,DGKG,ERBB4,GLIS3,SLC1A2,APOE,NTRK2,NKAIN3,TNC,CNTN1,MSI2,NRXN1,NEBL,ADCY2,CDH20,PARD3,NTM,PRKG1,DTNA,NPAS3,CTNND2,GPC5,DCLK2,RFX4,SLC14A1,NRG3,SOX5,SLC4A4,ABLIM1,RORA,CLU,LSAMP,TRPM3,MACF1,HPSE2
1.308e-07	-15.85	cell development	biological process	GO:0048468	2236	21	18204	50	TNC,CNTN1,NEBL,ERBB4,TNIK,DGKG,NTRK2,NTM,APOE,PARD3,FMN2,DCLK2,CTNNA2,PRKG1,GPM6A,CTNND2,MSI2,NRXN1,GFAP,RORA,CLU
1.359e-07	-15.81	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	24	16828	48	RYR3,FMN2,GPM6A,PLCB1,LRP1B,NKAIN3,TNC,NTRK2,SLC1A2,CNTN1,ERBB4,NAV2,CTNND2,GPC5,PARD3,PRKG1,ADCY2,NEBL,HPSE2,TRPM3,SOX5,LSAMP,RFX4,NRG3
1.534e-07	-15.69	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	21	16828	48	ADCY2,CDH20,NEBL,RYR3,GPC5,CTNND2,PARD3,PLCB1,FMN2,GPM6A,LRP1B,PRKG1,NRG3,NAV2,ERBB4,HPSE2,SOX5,SLC1A2,NTRK2,NKAIN3,LSAMP
1.534e-07	-15.69	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	21	16828	48	CDH20,ADCY2,NEBL,GPC5,CTNND2,RYR3,PRKG1,LRP1B,PLCB1,FMN2,GPM6A,PARD3,NRG3,ERBB4,NAV2,HPSE2,LSAMP,NTRK2,NKAIN3,SOX5,SLC1A2
1.781e-07	-15.54	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	21	16828	48	SOX5,SLC1A2,NTRK2,NKAIN3,LSAMP,HPSE2,ERBB4,NAV2,NRG3,PARD3,PLCB1,FMN2,GPM6A,LRP1B,PRKG1,RYR3,GPC5,CTNND2,NEBL,ADCY2,CDH20
2.064e-07	-15.39	anatomical structure development	biological process	GO:0048856	5207	32	18204	50	CNTN1,NEBL,NTRK2,LSAMP,NTM,PLCB1,CTNND2,GPM6A,CTNNA2,PRKG1,DCLK2,CAMK2G,PARD3,SOX5,NAV2,ATP1A2,RORA,NRG3,ABLIM1,ERBB4,TNC,RFX4,APOE,DGKG,TNIK,SLC1A2,MSI2,CDH20,FMN2,CLU,GFAP,NRXN1
2.662e-07	-15.14	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	15	16828	48	SOX5,SLC1A2,ERBB4,NAV2,DGKG,NRG3,PLCB1,FMN2,PARD3,PRKG1,LRP1B,RYR3,GPC5,ADCY2,CDH20
3.141e-07	-14.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	23	16828	48	FMN2,GPM6A,PLCB1,LRP1B,RYR3,ERBB4,NAV2,NTRK2,NKAIN3,TNC,SLC1A2,CNTN1,NEBL,ADCY2,PARD3,PRKG1,GPC5,CTNND2,NRG3,RFX4,SOX5,LSAMP,HPSE2
3.366e-07	-14.90	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	6	16828	48	PLCB1,NKAIN3,GPM6A,LRP1B,LSAMP,CTNND2
4.322e-07	-14.65	brain development	biological process	GO:0007420	724	12	18204	50	RORA,ATP1A2,NRG3,PRKG1,CTNNA2,DCLK2,RFX4,SLC1A2,PLCB1,NTRK2,ERBB4,CNTN1
4.343e-07	-14.65	nodular	COSMIC cancer mutations	nodular	1515	17	16828	48	DCLK2,DGKG,ERBB4,GLIS3,ABLIM1,CNTN1,SLC4A4,NTRK2,MACF1,ATP1A2,NEBL,CDH20,LRP1B,FMN2,PLCB1,NPAS3,CTNND2
6.984e-07	-14.17	brainstem	COSMIC cancer mutations	brainstem	3102	24	16828	48	PRKG1,PARD3,CTNND2,GPC5,NPAS3,CDH20,ADCY2,LSAMP,RORA,SOX5,HPSE2,NRG3,SLC14A1,LRP1B,FMN2,GPM6A,PLCB1,TNIK,RYR3,TNC,NKAIN3,SLC1A2,ERBB4,NAV2
7.803e-07	-14.06	telencephalon development	biological process	GO:0021537	276	8	18204	50	ERBB4,DCLK2,NTRK2,SLC1A2,NRG3,PLCB1,RFX4,ATP1A2
8.774e-07	-13.95	head development	biological process	GO:0060322	774	12	18204	50	CNTN1,ERBB4,PLCB1,SLC1A2,NTRK2,RFX4,DCLK2,PRKG1,CTNNA2,NRG3,RORA,ATP1A2
8.926e-07	-13.93	multicellular organismal process	biological process	GO:0032501	6177	34	18204	50	GFAP,CLU,NRXN1,CDH20,MSI2,RYR3,APOE,RFX4,SLC1A2,DGKG,TNIK,TNC,ERBB4,ATP1A2,RORA,NAV2,ABLIM1,NRG3,CTNNA2,PRKG1,CTNND2,GPM6A,SOX5,PARD3,CAMK2G,DCLK2,DTNA,PLCB1,NTM,LSAMP,NTRK2,SLC4A4,CNTN1,NEBL
1.254e-06	-13.59	Salivary secretion	KEGG pathways	ko04970	90	6	7161	29	CST3,RYR3,PRKG1,ADCY2,ATP1A2,PLCB1
1.254e-06	-13.59	Salivary secretion	KEGG pathways	hsa04970	90	6	7161	29	RYR3,PRKG1,ATP1A2,ADCY2,PLCB1,CST3
1.278e-06	-13.57	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	15	16828	48	MACF1,HPSE2,NTRK2,TNC,ABLIM1,NRG3,RYR3,CTNND2,TNIK,FMN2,GPM6A,NTM,LRP1B,ADCY2,NEBL
1.278e-06	-13.57	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	15	16828	48	LRP1B,GPM6A,FMN2,TNIK,NTM,CTNND2,RYR3,NEBL,ADCY2,ABLIM1,TNC,NTRK2,HPSE2,MACF1,NRG3
1.407e-06	-13.47	cell junction	cellular component	GO:0030054	2224	19	19108	50	SORBS1,ATP1A2,PLCB1,ERBB4,TNC,NRG3,CNTN1,DTNA,CLU,NRXN1,CTNND2,GPM6A,APOE,CDH20,CTNNA2,PARD3,TNIK,SLC1A2,NTRK2
1.452e-06	-13.44	forebrain development	biological process	GO:0030900	408	9	18204	50	PRKG1,DCLK2,ERBB4,RFX4,ATP1A2,NRG3,PLCB1,SLC1A2,NTRK2
1.499e-06	-13.41	cell junction organization	biological process	GO:0034330	532	10	18204	50	TNC,PARD3,ERBB4,CDH20,CTNND2,GPM6A,NRG3,NRXN1,APOE,SORBS1
1.570e-06	-13.36	Htt (huntingtin)	protein interactions	15194	77	5	19454	50	NTM,GFAP,CNTN1,LSAMP,GPM6A
1.623e-06	-13.33	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	8	19454	50	MACF1,TNIK,NEBL,DTNA,ABLIM1,CTNNA2,SORBS1,PARD3
1.713e-06	-13.28	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	25	16828	48	RYR3,LRP1B,FMN2,PLCB1,TNIK,PITPNC1,MGAT4C,MSI2,NTRK2,NAV2,ERBB4,GPC5,CTNND2,NPAS3,DTNA,PRKG1,PARD3,ADCY2,HPSE2,MACF1,TRPM3,LSAMP,CLU,SLC4A4,NRG3
1.713e-06	-13.28	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	25	16828	48	DTNA,GPC5,CTNND2,NPAS3,PARD3,PRKG1,ADCY2,MACF1,HPSE2,TRPM3,SLC4A4,CLU,LSAMP,NRG3,RYR3,PLCB1,TNIK,FMN2,LRP1B,PITPNC1,MGAT4C,MSI2,NTRK2,ERBB4,NAV2
1.759e-06	-13.25	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	21	16828	48	ADCY2,CDH20,RYR3,CTNND2,GPC5,TNIK,FMN2,PLCB1,GPM6A,PARD3,PRKG1,LRP1B,NRG3,SLC14A1,ERBB4,NAV2,HPSE2,NKAIN3,SOX5,LSAMP,RORA
1.935e-06	-13.16	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	8	16828	48	GPC5,ADCY2,PRKG1,LRP1B,FMN2,NKAIN3,GPM6A,SOX5
2.063e-06	-13.09	cell differentiation	biological process	GO:0030154	3645	25	18204	50	PRKG1,CTNNA2,CTNND2,GPM6A,SOX5,PARD3,CAMK2G,DCLK2,RORA,NAV2,CNTN1,NEBL,PLCB1,NTM,NTRK2,MSI2,FMN2,GFAP,CLU,NRXN1,TNC,ERBB4,APOE,TNIK,DGKG
2.083e-06	-13.08	developmental process	biological process	GO:0032502	5716	32	18204	50	APOE,RFX4,DGKG,TNIK,SLC1A2,ERBB4,TNC,CLU,GFAP,NRXN1,MSI2,CDH20,FMN2,NTRK2,NTM,LSAMP,PLCB1,NEBL,CNTN1,NAV2,RORA,ATP1A2,NRG3,ABLIM1,CTNND2,GPM6A,CTNNA2,PRKG1,DCLK2,CAMK2G,SOX5,PARD3
2.096e-06	-13.08	cellular developmental process	biological process	GO:0048869	3648	25	18204	50	PLCB1,NTM,NTRK2,CNTN1,NEBL,RORA,NAV2,CTNNA2,PRKG1,CTNND2,GPM6A,PARD3,SOX5,CAMK2G,DCLK2,APOE,TNIK,DGKG,TNC,ERBB4,GFAP,CLU,NRXN1,MSI2,FMN2
2.098e-06	-13.07	scalp	COSMIC cancer mutations	scalp	2110	19	16828	48	ERBB4,TNC,SOX5,SLC4A4,LSAMP,CNTN1,RORA,NRXN1,MACF1,NEBL,ATP1A2,PLCB1,SORBS1,FMN2,NTM,GFAP,PRKG1,CAMK2G,GPC5
2.165e-06	-13.04	neuron projection development	biological process	GO:0031175	693	11	18204	50	GFAP,NRXN1,CTNND2,GPM6A,PRKG1,CTNNA2,PARD3,APOE,TNIK,CNTN1,TNC
2.853e-06	-12.77	regulation of neuron projection development	biological process	GO:0010975	443	9	18204	50	GFAP,APOE,DGKG,NTRK2,TNIK,MACF1,CTNNA2,CNTN1,CAMK2G
2.948e-06	-12.73	anatomical structure morphogenesis	biological process	GO:0009653	2225	19	18204	50	TNC,CNTN1,NEBL,ERBB4,NTRK2,TNIK,APOE,PARD3,SOX5,PRKG1,CTNNA2,CDH20,GPM6A,CTNND2,NRG3,ABLIM1,NRXN1,RORA,CLU
4.460e-06	-12.32	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	34	16828	48	CDH20,ADCY2,PRKG1,PARD3,NTM,NPAS3,GPC5,CTNND2,RFX4,NRG3,ABLIM1,RORA,CLU,SOX5,SLC4A4,TRPM3,HPSE2,MACF1,MGAT4C,PITPNC1,LRP1B,GFAP,SORBS1,PLCB1,FMN2,GPM6A,RYR3,NAV2,DGKG,ERBB4,CNTN1,SLC1A2,APOE,TNC
5.917e-06	-12.04	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	36	16828	48	CNTN1,SLC1A2,NKAIN3,NTRK2,NRXN1,DGKG,ERBB4,NAV2,GLIS3,LRP1B,TNIK,FMN2,PLCB1,SORBS1,GPM6A,RYR3,PITPNC1,RORA,ABLIM1,LSAMP,SLC4A4,SOX5,TRPM3,HPSE2,MACF1,DCLK2,RFX4,NRG3,PRKG1,NTM,PARD3,NPAS3,GPC5,CTNND2,NEBL,ADCY2
6.387e-06	-11.96	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	36	16828	48	DGKG,ERBB4,NAV2,SLC1A2,TNC,NTRK2,CNTN1,NRXN1,ATP1A2,PITPNC1,GFAP,PLCB1,FMN2,LRP1B,RYR3,CST3,DCLK2,RFX4,SLC14A1,NRG3,SLC4A4,SOX5,RORA,CLU,LSAMP,TRPM3,HPSE2,MACF1,NEBL,ADCY2,CDH20,PARD3,NTM,PRKG1,NPAS3,CTNND2
6.387e-06	-11.96	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	36	16828	48	DGKG,ERBB4,NAV2,CNTN1,SLC1A2,TNC,NTRK2,NRXN1,ATP1A2,PITPNC1,LRP1B,GFAP,PLCB1,FMN2,RYR3,DCLK2,CST3,SLC14A1,RFX4,NRG3,RORA,CLU,LSAMP,SLC4A4,SOX5,TRPM3,HPSE2,MACF1,NEBL,CDH20,ADCY2,PRKG1,NTM,PARD3,NPAS3,CTNND2
7.941e-06	-11.74	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	48	16828	48	DGKG,MSI2,CNTN1,NTRK2,MGAT4C,RYR3,GPM6A,SORBS1,FMN2,GFAP,SLC14A1,DCLK2,TRPM3,ABLIM1,SLC4A4,SOX5,CDH20,ADCY2,CTNND2,NPAS3,PARD3,GLIS3,ERBB4,NAV2,NRXN1,NKAIN3,TNC,APOE,SLC1A2,PITPNC1,ATP1A2,LRP1B,PLCB1,TNIK,RFX4,NRG3,CST3,HPSE2,MACF1,LSAMP,CLU,RORA,NEBL,GPC5,DTNA,CAMK2G,PRKG1,NTM
8.691e-06	-11.65	trunk	COSMIC cancer mutations	trunk	3554	24	16828	48	NEBL,MGAT4C,ATP1A2,CDH20,LRP1B,PARD3,PLCB1,NPAS3,CTNND2,RYR3,DCLK2,DGKG,ERBB4,SLC14A1,NRG3,GLIS3,ABLIM1,LSAMP,SOX5,NTRK2,TNC,HPSE2,MACF1,NRXN1
9.200e-06	-11.60	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	14	16828	48	NEBL,ATP1A2,CDH20,LRP1B,PLCB1,NPAS3,CTNND2,DCLK2,ERBB4,DGKG,GLIS3,ABLIM1,NTRK2,MACF1
9.591e-06	-11.55	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	13	18204	50	TNC,CNTN1,TNIK,APOE,RFX4,PARD3,CTNNA2,PRKG1,CTNND2,GPM6A,ABLIM1,NRXN1,GFAP
1.097e-05	-11.42	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	10	18204	50	DGKG,TNIK,NTRK2,GFAP,APOE,CNTN1,CAMK2G,CTNNA2,MACF1,GPM6A
1.140e-05	-11.38	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	37	16828	48	ADCY2,CDH20,NEBL,CAMK2G,CTNND2,GPC5,PARD3,PRKG1,RFX4,NRG3,DCLK2,TRPM3,HPSE2,MACF1,SOX5,SLC4A4,RORA,ABLIM1,LSAMP,CLU,ATP1A2,RYR3,TNIK,PLCB1,GPM6A,FMN2,LRP1B,GLIS3,ERBB4,NAV2,DGKG,SLC1A2,NKAIN3,NTRK2,TNC,APOE,CNTN1
1.189e-05	-11.34	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	5	16828	48	LRP1B,PRKG1,PARD3,GPC5,NRG3
1.203e-05	-11.33	cell junction assembly	biological process	GO:0034329	285	7	18204	50	NRXN1,NRG3,SORBS1,ERBB4,PARD3,GPM6A,CDH20
1.353e-05	-11.21	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	7	19454	50	DTNA,ABLIM1,TNIK,MACF1,FMN2,PLCB1,PARD3
1.366e-05	-11.20	regulation of cell projection organization	biological process	GO:0031344	683	10	18204	50	CAMK2G,CNTN1,GPM6A,MACF1,CTNNA2,NTRK2,TNIK,DGKG,GFAP,APOE
1.376e-05	-11.19	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	17	16828	48	HPSE2,MACF1,NRXN1,RORA,CNTN1,SLC4A4,SOX5,ERBB4,NPAS3,RYR3,LRP1B,TNIK,GPM6A,PLCB1,FMN2,MGAT4C,NEBL
1.395e-05	-11.18	larynx	COSMIC cancer mutations	larynx	1948	17	16828	48	NEBL,MGAT4C,FMN2,GPM6A,TNIK,PLCB1,LRP1B,RYR3,NPAS3,ERBB4,SOX5,SLC4A4,CNTN1,RORA,NRXN1,HPSE2,MACF1
1.423e-05	-11.16	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	12	16828	48	CTNND2,GPC5,PARD3,PRKG1,LRP1B,ADCY2,HPSE2,NKAIN3,SOX5,LSAMP,RORA,NRG3
1.437e-05	-11.15	cell morphogenesis	biological process	GO:0000902	687	10	18204	50	CNTN1,PARD3,GPM6A,CTNND2,CTNNA2,CDH20,PRKG1,TNIK,NRXN1,CLU
1.487e-05	-11.12	cell projection organization	biological process	GO:0030030	1200	13	18204	50	PARD3,PRKG1,CTNNA2,GPM6A,CTNND2,ABLIM1,NRXN1,GFAP,TNC,CNTN1,TNIK,APOE,RFX4
1.562e-05	-11.07	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	42	16828	48	LRP1B,FMN2,TNIK,GPM6A,PLCB1,SORBS1,RYR3,MGAT4C,ATP1A2,PITPNC1,CNTN1,TNC,NKAIN3,NTRK2,MSI2,NRXN1,DGKG,NAV2,ERBB4,PRKG1,PARD3,NTM,NPAS3,GPC5,CTNND2,DTNA,CAMK2G,NEBL,CDH20,RORA,ABLIM1,CLU,SOX5,SLC4A4,TRPM3,HPSE2,MACF1,DCLK2,CST3,SLC14A1,RFX4,NRG3
1.569e-05	-11.06	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	43	16828	48	DTNA,NPAS3,CTNND2,GPC5,NTM,PARD3,PRKG1,ADCY2,CDH20,NEBL,TRPM3,MACF1,HPSE2,SOX5,SLC4A4,ABLIM1,RORA,LSAMP,NRG3,RFX4,DCLK2,RYR3,GFAP,GPM6A,PLCB1,FMN2,SORBS1,TNIK,LRP1B,MGAT4C,ATP1A2,PITPNC1,NRXN1,SLC1A2,APOE,NKAIN3,NTRK2,TNC,CNTN1,GLIS3,ERBB4,NAV2,DGKG
1.569e-05	-11.06	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	43	16828	48	TRPM3,MACF1,HPSE2,SLC4A4,SOX5,RORA,ABLIM1,LSAMP,RFX4,NRG3,DCLK2,DTNA,NPAS3,CTNND2,GPC5,PARD3,NTM,PRKG1,ADCY2,CDH20,NEBL,NRXN1,SLC1A2,NTRK2,APOE,NKAIN3,TNC,CNTN1,GLIS3,DGKG,ERBB4,NAV2,RYR3,GFAP,TNIK,FMN2,GPM6A,PLCB1,SORBS1,LRP1B,ATP1A2,MGAT4C,PITPNC1
1.570e-05	-11.06	membrane	cellular component	GO:0016020	9220	39	19108	50	CTNNA2,HPSE2,GPC5,LRP1B,CTNND2,NRXN1,CAMK2G,APOE,NRG3,MAPK10,GFAP,CLU,SORBS1,TRPM3,NKAIN3,RYR3,PLCB1,ADCY2,CDH20,PARD3,SLC4A4,PRKG1,TNIK,SLC1A2,NTRK2,MACF1,SLC14A1,GPM6A,NTM,DGKG,LSAMP,CNTN1,DTNA,FMN2,MGAT4C,CST3,ATP1A2,ERBB4,TNC
1.589e-05	-11.05	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	42	16828	48	PITPNC1,ATP1A2,MGAT4C,LRP1B,SORBS1,GPM6A,FMN2,PLCB1,TNIK,RYR3,NAV2,ERBB4,DGKG,CNTN1,NTRK2,TNC,NKAIN3,MSI2,NRXN1,NEBL,CDH20,PRKG1,NTM,PARD3,CTNND2,GPC5,NPAS3,CAMK2G,DTNA,DCLK2,CST3,NRG3,RFX4,SLC14A1,CLU,ABLIM1,RORA,SOX5,SLC4A4,HPSE2,MACF1,TRPM3
1.642e-05	-11.02	synapse	cellular component	GO:0045202	1473	14	19108	50	CLU,NRG3,CNTN1,DTNA,PLCB1,ATP1A2,ERBB4,NTRK2,SLC1A2,TNIK,GPM6A,APOE,CTNND2,NRXN1
1.750e-05	-10.95	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	25	16828	48	PITPNC1,ATP1A2,LRP1B,TNIK,FMN2,PLCB1,GPM6A,RYR3,NAV2,DGKG,ERBB4,GLIS3,NTRK2,TNC,SLC1A2,NEBL,ADCY2,PRKG1,PARD3,CTNND2,NPAS3,CAMK2G,RFX4,SLC4A4,MACF1
1.758e-05	-10.95	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	25	16828	48	RFX4,SLC4A4,MACF1,NEBL,ADCY2,PRKG1,PARD3,CTNND2,NPAS3,CAMK2G,DGKG,NAV2,ERBB4,GLIS3,NTRK2,TNC,SLC1A2,PITPNC1,ATP1A2,LRP1B,PLCB1,GPM6A,TNIK,FMN2,RYR3
1.766e-05	-10.94	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	3	19454	50	NRXN1,CTNND2,CST3
1.776e-05	-10.94	tibia	COSMIC cancer mutations	tibia	836	11	16828	48	PRKG1,LSAMP,LRP1B,ABLIM1,TNIK,PLCB1,GPM6A,NKAIN3,MACF1,CTNND2,TRPM3
1.850e-05	-10.90	FLOT1 (flotillin 1)	protein interactions	10211	453	8	19454	50	MACF1,SOX5,FMN2,ABLIM1,DTNA,SLC14A1,SORBS1,PARD3
1.869e-05	-10.89	cell projection	cellular component	GO:0042995	2398	18	19108	50	PARD3,CTNNA2,ADCY2,NTRK2,SLC1A2,CAMK2G,MACF1,NRXN1,CTNND2,APOE,GPM6A,ABLIM1,CNTN1,DTNA,CLU,GFAP,FMN2,ATP1A2
2.022e-05	-10.81	humerus	COSMIC cancer mutations	humerus	546	9	16828	48	GPC5,GPM6A,FMN2,NKAIN3,SOX5,PRKG1,LRP1B,ADCY2,NEBL
2.057e-05	-10.79	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	25	16828	48	ADCY2,NEBL,NPAS3,CTNND2,CAMK2G,PRKG1,PARD3,RFX4,MACF1,SLC4A4,ATP1A2,PITPNC1,RYR3,LRP1B,PLCB1,TNIK,GPM6A,FMN2,GLIS3,DGKG,ERBB4,NAV2,SLC1A2,NTRK2,TNC
2.187e-05	-10.73	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	31	16828	48	NRG3,TRPM3,HPSE2,MACF1,SOX5,RORA,CLU,LSAMP,ADCY2,CDH20,NEBL,CAMK2G,NPAS3,CTNND2,GPC5,PARD3,PRKG1,GLIS3,ERBB4,NAV2,SLC1A2,TNC,APOE,NTRK2,NKAIN3,RYR3,FMN2,SORBS1,GPM6A,PLCB1,LRP1B
2.291e-05	-10.68	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	13	16828	48	NRG3,NKAIN3,SOX5,LSAMP,RORA,HPSE2,ADCY2,TNIK,PARD3,PRKG1,LRP1B,GPC5,CTNND2
2.334e-05	-10.67	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	9	16828	48	NTRK2,PLCB1,SLC4A4,PRKG1,LRP1B,RYR3,CTNND2,ERBB4,ADCY2
2.401e-05	-10.64	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	9	16828	48	ERBB4,ADCY2,LRP1B,PRKG1,SLC4A4,NTRK2,PLCB1,CTNND2,RYR3
2.463e-05	-10.61	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	5	19454	50	NTRK2,PARD3,ERBB4,DTNA,ABLIM1
2.501e-05	-10.60	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	17	16828	48	MSI2,TRPM3,MACF1,RORA,ABLIM1,LSAMP,NRG3,ERBB4,NAV2,GPC5,PARD3,GFAP,GPM6A,FMN2,PLCB1,LRP1B,NEBL
2.613e-05	-10.55	glial cell development	biological process	GO:0021782	128	5	18204	50	PARD3,CNTN1,NTRK2,GFAP,CLU
2.674e-05	-10.53	neuron projection	cellular component	GO:0043005	1331	13	19108	50	ATP1A2,CNTN1,DTNA,CLU,CAMK2G,CTNND2,GPM6A,APOE,CTNNA2,ADCY2,PARD3,NTRK2,SLC1A2
3.271e-05	-10.33	synapse organization	biological process	GO:0050808	333	7	18204	50	NRXN1,NRG3,APOE,ERBB4,TNC,GPM6A,CTNND2
3.589e-05	-10.24	Circadian entrainment	KEGG pathways	hsa04713	96	5	7161	29	PLCB1,ADCY2,PRKG1,CAMK2G,RYR3
3.589e-05	-10.24	Circadian entrainment	KEGG pathways	ko04713	96	5	7161	29	ADCY2,PLCB1,RYR3,CAMK2G,PRKG1
3.952e-05	-10.14	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	17	19108	50	ADCY2,CTNNA2,PARD3,SLC1A2,NTRK2,CTNND2,MACF1,CAMK2G,GPM6A,ABLIM1,APOE,DTNA,CNTN1,GFAP,CLU,FMN2,ATP1A2
4.604e-05	-9.99	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	5	16828	48	PARD3,LRP1B,PRKG1,GPC5,NRG3
4.700e-05	-9.97	bone	COSMIC cancer mutations	bone	8157	37	16828	48	NEBL,ADCY2,PRKG1,PARD3,GPC5,CTNND2,NPAS3,DTNA,CAMK2G,DCLK2,CST3,NRG3,LSAMP,RORA,ABLIM1,SLC4A4,SOX5,MACF1,HPSE2,TRPM3,ATP1A2,LRP1B,TNIK,PLCB1,FMN2,GPM6A,SORBS1,RYR3,ERBB4,NAV2,DGKG,GLIS3,CNTN1,NTRK2,TNC,NKAIN3,NRXN1
4.755e-05	-9.95	face	COSMIC cancer mutations	face	2139	17	16828	48	FMN2,GPM6A,PLCB1,GFAP,PARD3,LRP1B,GPC5,NEBL,LSAMP,RORA,ABLIM1,MSI2,MACF1,TRPM3,NAV2,ERBB4,NRG3
4.839e-05	-9.94	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	12	16828	48	CTNND2,LRP1B,PRKG1,NTM,PLCB1,SORBS1,ADCY2,MGAT4C,MACF1,SLC4A4,TNC,ERBB4
4.882e-05	-9.93	neuron projection morphogenesis	biological process	GO:0048812	486	8	18204	50	PRKG1,CTNNA2,GPM6A,CTNND2,PARD3,CNTN1,TNIK,NRXN1
5.002e-05	-9.90	LRRC7 (leucine rich repeat containing 7)	protein interactions	57554	28	3	19454	50	CAMK2G,CTNND2,ERBB4
5.199e-05	-9.86	adenoma	COSMIC cancer mutations	adenoma	2873	20	16828	48	ERBB4,DCLK2,HPSE2,MACF1,TRPM3,NTRK2,APOE,TNC,SOX5,ADCY2,CDH20,NEBL,RYR3,CTNND2,GPC5,NPAS3,GPM6A,PARD3,PRKG1,LRP1B
5.246e-05	-9.86	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	8	18204	50	NRXN1,TNIK,CNTN1,PARD3,GPM6A,CTNND2,PRKG1,CTNNA2
5.463e-05	-9.81	cellular component assembly	biological process	GO:0022607	2472	18	18204	50	APOE,RFX4,SLC1A2,TNIK,TRPM3,ERBB4,NEBL,CNTN1,SORBS1,CLU,ABLIM1,NRG3,NRXN1,CDH20,GPM6A,RYR3,FMN2,PARD3
5.634e-05	-9.78	cell projection morphogenesis	biological process	GO:0048858	496	8	18204	50	NRXN1,TNIK,CNTN1,PARD3,CTNND2,GPM6A,PRKG1,CTNNA2
5.838e-05	-9.75	signaling	biological process	GO:0023052	4968	27	18204	50	TNC,ERBB4,APOE,SLC1A2,DGKG,TNIK,RYR3,FMN2,CLU,NRXN1,ADCY2,CNTN1,PLCB1,DTNA,NTRK2,PITPNC1,PRKG1,MACF1,CTNND2,PARD3,DCLK2,CAMK2G,RORA,ATP1A2,SORBS1,NRG3,MAPK10
6.759e-05	-9.60	cellular component organization	biological process	GO:0016043	5636	29	18204	50	FMN2,CDH20,RYR3,NRXN1,GFAP,CLU,TNC,ERBB4,SLC1A2,TNIK,RFX4,APOE,PARD3,HPSE2,DCLK2,CTNNA2,PRKG1,MACF1,GPM6A,CTNND2,NRG3,ABLIM1,NAV2,SORBS1,CST3,CNTN1,NEBL,TRPM3,PITPNC1
6.775e-05	-9.60	negative regulation of amyloid-beta formation	biological process	GO:1902430	29	3	18204	50	APOE,CLU,NTRK2
6.848e-05	-9.59	cell communication	biological process	GO:0007154	5010	27	18204	50	PITPNC1,NTRK2,DTNA,PLCB1,CNTN1,ADCY2,MAPK10,NRG3,SORBS1,ATP1A2,RORA,CAMK2G,DCLK2,PARD3,CTNND2,MACF1,PRKG1,TNIK,DGKG,SLC1A2,APOE,ERBB4,TNC,NRXN1,CLU,FMN2,RYR3
7.047e-05	-9.56	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	6	16828	48	ADCY2,GPC5,HPSE2,NRG3,NPAS3,ERBB4
7.047e-05	-9.56	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	6	16828	48	ERBB4,ADCY2,HPSE2,GPC5,NRG3,NPAS3
7.224e-05	-9.54	Nuclear signaling by ERBB4	REACTOME pathways	R-HSA-1251985	25	3	10285	34	GFAP,NRG3,ERBB4
7.355e-05	-9.52	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	2	18204	50	CLU,APOE
7.355e-05	-9.52	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	50	GFAP,SLC1A2
7.355e-05	-9.52	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	50	GFAP,SLC1A2
7.385e-05	-9.51	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	9	19454	50	DTNA,ABLIM1,ERBB4,TNIK,MACF1,FMN2,MSI2,PARD3,PLCB1
7.526e-05	-9.49	pharynx	COSMIC cancer mutations	pharynx	2696	19	16828	48	RFX4,NRG3,SLC14A1,DGKG,MACF1,CLU,SLC4A4,SLC1A2,NTRK2,ATP1A2,PITPNC1,NPAS3,GPC5,CTNND2,DTNA,RYR3,LRP1B,SORBS1,FMN2
7.616e-05	-9.48	presynaptic membrane	cellular component	GO:0042734	168	5	19108	50	GPM6A,ERBB4,SLC1A2,NRXN1,CNTN1
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	NTM,LSAMP,GPM6A
8.302e-05	-9.40	negative regulation of amyloid precursor protein catabolic process	biological process	GO:1902992	31	3	18204	50	CLU,APOE,NTRK2
8.559e-05	-9.37	plasma membrane region	cellular component	GO:0098590	1278	12	19108	50	CNTN1,PARD3,TNIK,SLC1A2,SLC4A4,MACF1,SLC14A1,NRXN1,SORBS1,ERBB4,GPM6A,ATP1A2
9.242e-05	-9.29	glutamatergic synapse	cellular component	GO:0098978	412	7	19108	50	GPM6A,PLCB1,ERBB4,APOE,TNIK,SLC1A2,NRG3
9.955e-05	-9.21	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	22	16828	48	TRPM3,HPSE2,MACF1,SOX5,SLC4A4,ABLIM1,NRG3,GPC5,CTNND2,PARD3,ADCY2,NEBL,TNC,NAV2,DGKG,RYR3,GFAP,FMN2,GPM6A,TNIK,LRP1B,ATP1A2
1.004e-04	-9.21	middle_third	COSMIC cancer mutations	middle_third	3533	22	16828	48	TNIK,GPM6A,FMN2,PARD3,GFAP,LRP1B,RYR3,GPC5,CTNND2,ATP1A2,NEBL,ADCY2,TNC,SLC4A4,SOX5,ABLIM1,MACF1,HPSE2,TRPM3,DGKG,NAV2,NRG3
1.099e-04	-9.12	negative regulation of amide metabolic process	biological process	GO:0034249	34	3	18204	50	NTRK2,APOE,CLU
1.101e-04	-9.11	D-amino acid transport	biological process	GO:0042940	6	2	18204	50	SLC1A2,GFAP
1.101e-04	-9.11	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	2	18204	50	ERBB4,NRG3
1.108e-04	-9.11	cytoskeleton organization	biological process	GO:0007010	1251	12	18204	50	MACF1,CTNNA2,PRKG1,DCLK2,PARD3,FMN2,SORBS1,GFAP,ABLIM1,NEBL,APOE,TNIK
1.122e-04	-9.10	PLCB3 (phospholipase C beta 3)	protein interactions	5331	97	4	19454	50	PLCB1,PARD3,PRKG1,CAMK2G
1.179e-04	-9.05	cell adhesion molecule binding	molecular function	GO:0050839	560	8	18094	49	TNC,CDH20,NRXN1,CTNNA2,MACF1,CTNND2,CNTN1,GFAP
1.251e-04	-8.99	proteoglycan binding	molecular function	GO:0043394	36	3	18094	49	TNC,APOE,HPSE2
1.293e-04	-8.95	adherens junction	cellular component	GO:0005912	188	5	19108	50	SORBS1,CDH20,CTNNA2,PARD3,CTNND2
1.420e-04	-8.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	13	16828	48	NRXN1,TRPM3,SLC4A4,LSAMP,CNTN1,RYR3,CTNND2,GPC5,FMN2,SORBS1,TNIK,PARD3,LRP1B
1.425e-04	-8.86	cellular component organization or biogenesis	biological process	GO:0071840	5850	29	18204	50	TNC,ERBB4,RFX4,APOE,SLC1A2,TNIK,CDH20,RYR3,FMN2,GFAP,CLU,NRXN1,TRPM3,NEBL,CNTN1,PITPNC1,PRKG1,CTNNA2,CTNND2,GPM6A,MACF1,HPSE2,PARD3,DCLK2,SORBS1,NAV2,CST3,ABLIM1,NRG3
1.476e-04	-8.82	DZIP1 (DAZ interacting zinc finger protein 1)	protein interactions	22873	40	3	19454	50	PARD3,NTRK2,CAMK2G
1.520e-04	-8.79	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	31	16828	48	LRP1B,FMN2,PLCB1,TNIK,RYR3,PITPNC1,ATP1A2,CNTN1,NTRK2,NRXN1,NAV2,ERBB4,DGKG,PRKG1,NTM,PARD3,CTNND2,GPC5,CAMK2G,ADCY2,CLU,ABLIM1,RORA,SLC4A4,SOX5,HPSE2,MACF1,TRPM3,DCLK2,NRG3,RFX4
1.520e-04	-8.79	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	31	16828	48	RFX4,NRG3,DCLK2,HPSE2,MACF1,TRPM3,SLC4A4,SOX5,CLU,ABLIM1,RORA,ADCY2,CAMK2G,CTNND2,GPC5,PARD3,NTM,PRKG1,DGKG,ERBB4,NAV2,NRXN1,NTRK2,CNTN1,PITPNC1,ATP1A2,RYR3,FMN2,PLCB1,TNIK,LRP1B
1.531e-04	-8.78	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	7	19454	50	ERBB4,CTNND2,CAMK2G,DTNA,FMN2,MACF1,PARD3
1.558e-04	-8.77	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	30	16828	48	GPM6A,PLCB1,SORBS1,FMN2,LRP1B,ATP1A2,MGAT4C,NRXN1,TNC,NTRK2,GLIS3,ERBB4,NAV2,DGKG,DTNA,CAMK2G,GPC5,PARD3,PRKG1,ADCY2,CDH20,NEBL,HPSE2,MACF1,TRPM3,SLC4A4,CLU,ABLIM1,NRG3,RFX4
1.569e-04	-8.76	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	30	16828	48	MGAT4C,ATP1A2,LRP1B,FMN2,PLCB1,GPM6A,SORBS1,ERBB4,DGKG,NAV2,GLIS3,TNC,NTRK2,NRXN1,NEBL,CDH20,ADCY2,PRKG1,PARD3,GPC5,CAMK2G,DTNA,RFX4,NRG3,ABLIM1,CLU,SLC4A4,TRPM3,MACF1,HPSE2
1.627e-04	-8.72	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	5	19454	50	DTNA,CAMK2G,ATP1A2,RYR3,PARD3
1.795e-04	-8.63	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	2	19454	50	NTM,GFAP
1.886e-04	-8.58	cellular component biogenesis	biological process	GO:0044085	2716	18	18204	50	NRXN1,NRG3,ABLIM1,SORBS1,CLU,PARD3,FMN2,RYR3,GPM6A,CDH20,TNIK,SLC1A2,RFX4,APOE,NEBL,CNTN1,TRPM3,ERBB4
1.964e-04	-8.54	SH2D1A (SH2 domain containing 1A)	protein interactions	4068	44	3	19454	50	LRP1B,CAMK2G,ERBB4
1.993e-04	-8.52	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	21	16828	48	TNC,TRPM3,MACF1,NRXN1,NAV2,DGKG,ERBB4,NRG3,RFX4,GLIS3,LRP1B,PARD3,FMN2,PLCB1,GPC5,CTNND2,NEBL,MGAT4C,ATP1A2,PITPNC1,ADCY2
1.996e-04	-8.52	beta-catenin binding	molecular function	GO:0008013	107	4	18094	49	CDH20,CTNND2,RORA,CTNNA2
2.037e-04	-8.50	cell adhesion	biological process	GO:0007155	942	10	18204	50	SORBS1,NRXN1,NTM,LSAMP,CDH20,CTNNA2,CTNND2,PARD3,TNC,CNTN1
2.048e-04	-8.49	ERBB4 signaling pathway	biological process	GO:0038130	8	2	18204	50	NRG3,ERBB4
2.048e-04	-8.49	protein import	biological process	GO:0017038	8	2	18204	50	APOE,CLU
2.162e-04	-8.44	Gastric acid secretion	KEGG pathways	hsa04971	75	4	7161	29	CAMK2G,PLCB1,ATP1A2,ADCY2
2.162e-04	-8.44	Gastric acid secretion	KEGG pathways	ko04971	75	4	7161	29	PLCB1,ADCY2,ATP1A2,CAMK2G
2.276e-04	-8.39	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	31	16828	48	NRG3,DCLK2,TRPM3,MACF1,HPSE2,ABLIM1,SLC4A4,SOX5,ADCY2,NEBL,NPAS3,CTNND2,GPC5,PRKG1,PARD3,GLIS3,NAV2,ERBB4,NRXN1,CNTN1,TNC,ATP1A2,MGAT4C,PITPNC1,RYR3,LRP1B,PLCB1,GPM6A,FMN2,SORBS1,TNIK
2.276e-04	-8.39	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	9	16828	48	NEBL,DTNA,CTNND2,PLCB1,NTRK2,PARD3,SOX5,PRKG1,LRP1B
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	LSAMP,NTM
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.392e-04	-8.34	CNTN1 (contactin 1)	protein interactions	1272	47	3	19454	50	GPM6A,TNC,CNTN1
2.425e-04	-8.32	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	45	16828	48	DCLK2,ABLIM1,SLC4A4,SOX5,TRPM3,CDH20,ADCY2,PARD3,CTNND2,NPAS3,DGKG,CNTN1,NTRK2,MSI2,MGAT4C,GPM6A,SORBS1,FMN2,GFAP,RYR3,NRG3,RFX4,LSAMP,CLU,RORA,MACF1,HPSE2,NEBL,PRKG1,NTM,GPC5,CAMK2G,DTNA,NAV2,ERBB4,GLIS3,NKAIN3,TNC,SLC1A2,NRXN1,PITPNC1,ATP1A2,LRP1B,TNIK,PLCB1
2.426e-04	-8.32	regulation of localization	biological process	GO:0032879	2028	15	18204	50	DCLK2,CAMK2G,RYR3,PRKG1,CLU,NKAIN3,SORBS1,ATP1A2,GFAP,CNTN1,GPC5,ERBB4,PLCB1,SLC1A2,APOE
2.501e-04	-8.29	postsynapse	cellular component	GO:0098794	646	8	19108	50	CNTN1,NTRK2,TNIK,CTNND2,ERBB4,GPM6A,ATP1A2,PLCB1
2.544e-04	-8.28	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	11	16828	48	NTRK2,RORA,ERBB4,NAV2,RYR3,CAMK2G,CTNND2,TNIK,PRKG1,LRP1B,MGAT4C
2.564e-04	-8.27	OCLN (occludin)	protein interactions	100506658	495	7	19454	50	DTNA,ABLIM1,MACF1,TNIK,FMN2,NTRK2,PARD3
2.586e-04	-8.26	cellular response to organic cyclic compound	biological process	GO:0071407	464	7	18204	50	ATP1A2,RORA,SLC1A2,PLCB1,ADCY2,RYR3,TNC
2.597e-04	-8.26	behavior	biological process	GO:0007610	619	8	18204	50	CNTN1,SLC1A2,PLCB1,NRXN1,NTRK2,ATP1A2,APOE,NAV2
2.863e-04	-8.16	Prot_kinase_dom	interpro domains	IPR000719	480	7	18521	50	DCLK2,PRKG1,MAPK10,NTRK2,TNIK,CAMK2G,ERBB4
2.876e-04	-8.15	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	11	16828	48	ERBB4,MGAT4C,NAV2,CTNND2,RYR3,CAMK2G,PRKG1,RORA,LRP1B,NTRK2,TNIK
2.879e-04	-8.15	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	33	16828	48	NRG3,RFX4,MACF1,HPSE2,SOX5,SLC4A4,ABLIM1,RORA,LSAMP,CLU,ADCY2,CDH20,NEBL,GPC5,CTNND2,PARD3,PRKG1,GLIS3,DGKG,ERBB4,NAV2,SLC1A2,APOE,NKAIN3,NTRK2,TNC,CNTN1,ATP1A2,RYR3,FMN2,PLCB1,GPM6A,LRP1B
3.047e-04	-8.10	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	9	16828	48	PRKG1,SOX5,NTRK2,TNIK,CTNND2,CAMK2G,DCLK2,ERBB4,ADCY2
3.047e-04	-8.10	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	9	16828	48	PRKG1,NTRK2,TNIK,SOX5,CTNND2,CAMK2G,DCLK2,ERBB4,ADCY2
3.069e-04	-8.09	synapse assembly	biological process	GO:0007416	118	4	18204	50	ERBB4,NRXN1,NRG3,GPM6A
3.091e-04	-8.08	regulation of amyloid-beta formation	biological process	GO:1902003	48	3	18204	50	NTRK2,APOE,CLU
3.150e-04	-8.06	mucosal	COSMIC cancer mutations	mucosal	2009	15	16828	48	ATP1A2,NEBL,MGAT4C,CTNND2,SORBS1,FMN2,PLCB1,PARD3,LRP1B,NRG3,NAV2,ERBB4,TNC,ABLIM1,RORA
3.150e-04	-8.06	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	15	16828	48	ABLIM1,RORA,TNC,NAV2,ERBB4,NRG3,LRP1B,PARD3,FMN2,SORBS1,PLCB1,CTNND2,MGAT4C,ATP1A2,NEBL
3.162e-04	-8.06	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	4	19454	50	ABLIM1,DTNA,PARD3,MACF1
3.193e-04	-8.05	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	24	16828	48	NRG3,RFX4,CLU,ABLIM1,SOX5,MACF1,TRPM3,ADCY2,PRKG1,PARD3,CTNND2,DTNA,NAV2,DGKG,ERBB4,GLIS3,CNTN1,TNC,ATP1A2,MGAT4C,LRP1B,GPM6A,FMN2,RYR3
3.193e-04	-8.05	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	24	16828	48	GLIS3,NAV2,DGKG,ERBB4,TNC,CNTN1,MGAT4C,ATP1A2,RYR3,FMN2,GPM6A,LRP1B,RFX4,NRG3,TRPM3,MACF1,SOX5,ABLIM1,CLU,ADCY2,DTNA,CTNND2,PARD3,PRKG1
3.231e-04	-8.04	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	3	19454	50	SORBS1,NTRK2,ERBB4
3.281e-04	-8.02	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	50	NTRK2,ATP1A2
3.281e-04	-8.02	action potential propagation	biological process	GO:0098870	10	2	18204	50	NTRK2,ATP1A2
3.283e-04	-8.02	glial cell differentiation	biological process	GO:0010001	219	5	18204	50	PARD3,NTRK2,CNTN1,GFAP,CLU
3.502e-04	-7.96	ErbB signaling pathway	KEGG pathways	hsa04012	85	4	7161	29	CAMK2G,MAPK10,NRG3,ERBB4
3.502e-04	-7.96	ErbB signaling pathway	KEGG pathways	ko04012	85	4	7161	29	MAPK10,CAMK2G,ERBB4,NRG3
3.502e-04	-7.96	Insulin secretion	KEGG pathways	hsa04911	85	4	7161	29	CAMK2G,PLCB1,ATP1A2,ADCY2
3.613e-04	-7.93	SYNM (synemin)	protein interactions	23336	54	3	19454	50	ERBB4,DTNA,GFAP
3.636e-04	-7.92	interstitial matrix	cellular component	GO:0005614	11	2	19108	50	NAV2,TNC
3.661e-04	-7.91	SNCA (synuclein alpha)	protein interactions	6622	696	8	19454	50	CAMK2G,MACF1,TNIK,GPM6A,APOE,CLU,PLCB1,NTRK2
3.702e-04	-7.90	EZR (ezrin)	protein interactions	7430	526	7	19454	50	ABLIM1,DTNA,TNIK,NEBL,MACF1,MAPK10,SORBS1
3.713e-04	-7.90	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	5	16828	48	NAV2,MGAT4C,PLCB1,RFX4,DTNA
3.722e-04	-7.90	Signaling by ERBB4	REACTOME pathways	R-HSA-1236394	43	3	10285	34	NRG3,ERBB4,GFAP
3.778e-04	-7.88	modulation of chemical synaptic transmission	biological process	GO:0050804	494	7	18204	50	ATP1A2,APOE,GFAP,NRXN1,NTRK2,NRG3,PLCB1
3.824e-04	-7.87	regulation of trans-synaptic signaling	biological process	GO:0099177	495	7	18204	50	GFAP,APOE,ATP1A2,NRXN1,NTRK2,PLCB1,NRG3
3.863e-04	-7.86	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	8	16828	48	ERBB4,NEBL,CAMK2G,TNC,PLCB1,SORBS1,FMN2,NTM
4.182e-04	-7.78	myelination	biological process	GO:0042552	128	4	18204	50	CLU,PARD3,NTRK2,CNTN1
4.203e-04	-7.77	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	2	19454	50	CLU,APOE
4.290e-04	-7.75	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	7	16828	48	MACF1,CAMK2G,PRKG1,NTRK2,TNIK,DCLK2,ERBB4
4.382e-04	-7.73	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	5	16828	48	DTNA,RFX4,NAV2,MGAT4C,PLCB1
4.404e-04	-7.73	Ig_I-set	interpro domains	IPR013098	132	4	18521	50	CNTN1,NTM,NTRK2,LSAMP
4.434e-04	-7.72	ensheathment of neurons	biological process	GO:0007272	130	4	18204	50	CLU,PARD3,CNTN1,NTRK2
4.434e-04	-7.72	axon ensheathment	biological process	GO:0008366	130	4	18204	50	CNTN1,NTRK2,PARD3,CLU
4.561e-04	-7.69	non_seminoma	COSMIC cancer mutations	non_seminoma	492	7	16828	48	ERBB4,DCLK2,CAMK2G,MACF1,TNIK,NTRK2,PRKG1
4.626e-04	-7.68	regulation of amyloid precursor protein catabolic process	biological process	GO:1902991	55	3	18204	50	NTRK2,CLU,APOE
4.667e-04	-7.67	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	8	18094	49	MAPK10,NTRK2,DGKG,DCLK2,ERBB4,TNIK,CAMK2G,PRKG1
4.695e-04	-7.66	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	2	10285	34	ERBB4,NRG3
4.733e-04	-7.66	I-set	pfam domains	PF07679	132	4	17795	49	NTRK2,CNTN1,LSAMP,NTM
4.739e-04	-7.65	GnRH signaling pathway	KEGG pathways	ko04912	92	4	7161	29	MAPK10,CAMK2G,ADCY2,PLCB1
4.739e-04	-7.65	GnRH signaling pathway	KEGG pathways	hsa04912	92	4	7161	29	CAMK2G,MAPK10,PLCB1,ADCY2
4.797e-04	-7.64	Kinase-like_dom_sf	interpro domains	IPR011009	523	7	18521	50	NTRK2,MAPK10,PRKG1,DCLK2,CAMK2G,ERBB4,TNIK
4.907e-04	-7.62	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	12	16828	48	ADCY2,GPC5,RYR3,PRKG1,LRP1B,PLCB1,PARD3,NRG3,ERBB4,NAV2,HPSE2,TRPM3
5.100e-04	-7.58	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	6	18521	50	TNIK,ERBB4,CAMK2G,DCLK2,PRKG1,NTRK2
5.164e-04	-7.57	sarcolemma	cellular component	GO:0042383	142	4	19108	50	ATP1A2,PRKG1,RYR3,DTNA
5.336e-04	-7.54	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	14	16828	48	NEBL,PITPNC1,ADCY2,CDH20,PARD3,FMN2,PLCB1,LRP1B,RYR3,ERBB4,DGKG,TNC,NTRK2,HPSE2
5.354e-04	-7.53	Pancreatic secretion	KEGG pathways	ko04972	95	4	7161	29	PLCB1,SLC4A4,ATP1A2,ADCY2
5.354e-04	-7.53	Pancreatic secretion	KEGG pathways	hsa04972	95	4	7161	29	ATP1A2,ADCY2,SLC4A4,PLCB1
5.365e-04	-7.53	extremity	COSMIC cancer mutations	extremity	1876	14	16828	48	DGKG,ERBB4,NTRK2,TNC,HPSE2,PITPNC1,NEBL,CDH20,ADCY2,LRP1B,PLCB1,FMN2,PARD3,RYR3
5.583e-04	-7.49	regulation of synapse organization	biological process	GO:0050807	246	5	18204	50	GPM6A,CTNNA2,APOE,NTRK2,NRXN1
5.657e-04	-7.48	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	2	18204	50	CLU,APOE
5.739e-04	-7.46	cell body	cellular component	GO:0044297	556	7	19108	50	NRXN1,CTNND2,APOE,GPM6A,ATP1A2,SLC1A2,GFAP
5.776e-04	-7.46	C9 (complement C9)	protein interactions	735	14	2	19454	50	APOE,CLU
5.776e-04	-7.46	PLXNA4 (plexin A4)	protein interactions	91584	14	2	19454	50	GPM6A,CLU
5.795e-04	-7.45	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	4	7161	29	PLCB1,ADCY2,CAMK2G,MAPK10
5.795e-04	-7.45	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	4	7161	29	PLCB1,ADCY2,CAMK2G,MAPK10
6.009e-04	-7.42	regulation of cellular component organization	biological process	GO:0051128	2455	16	18204	50	NTRK2,DGKG,TNIK,PLCB1,APOE,CNTN1,TNC,NRXN1,NRG3,CLU,CST3,GFAP,CAMK2G,GPM6A,MACF1,CTNNA2
6.086e-04	-7.40	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	4	19454	50	MACF1,TNIK,PRKG1,CLU
6.128e-04	-7.40	pancreas-carcinoma-adenocarcinoma	COSMIC cancer mutations	pancreas-carcinoma-adenocarcinoma	517	7	16828	48	LRP1B,DCLK2,TNC,NEBL,MACF1,GPC5,HPSE2
6.132e-04	-7.40	intracellular signal transduction	biological process	GO:0035556	1505	12	18204	50	ADCY2,APOE,DGKG,TNIK,PLCB1,RYR3,PRKG1,DCLK2,FMN2,ATP1A2,MAPK10,NRG3
6.227e-04	-7.38	regulation of synapse structure or activity	biological process	GO:0050803	252	5	18204	50	NRXN1,NTRK2,APOE,CTNNA2,GPM6A
6.388e-04	-7.36	CDH1 (cadherin 1)	protein interactions	999	757	8	19454	50	PARD3,SORBS1,CTNNA2,CTNND2,ABLIM1,NAV2,NEBL,MACF1
6.409e-04	-7.35	EF-hand-dom_pair	interpro domains	IPR011992	258	5	18521	50	DTNA,PLCB1,MACF1,RYR3,DGKG
6.580e-04	-7.33	presynapse	cellular component	GO:0098793	569	7	19108	50	GPM6A,NTRK2,ERBB4,SLC1A2,TNIK,CNTN1,NRXN1
6.588e-04	-7.33	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	50	ATP1A2,SLC4A4
6.623e-04	-7.32	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	17	16828	48	CDH20,NEBL,MGAT4C,ATP1A2,CTNND2,RYR3,LRP1B,PLCB1,PARD3,SLC14A1,NRG3,ERBB4,HPSE2,NRXN1,LSAMP,TNC,SOX5
6.654e-04	-7.32	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	2	19454	50	PARD3,TNIK
7.079e-04	-7.25	Calcium signaling pathway	KEGG pathways	ko04020	181	5	7161	29	CAMK2G,RYR3,PLCB1,ERBB4,ADCY2
7.079e-04	-7.25	Calcium signaling pathway	KEGG pathways	hsa04020	181	5	7161	29	PLCB1,ERBB4,ADCY2,CAMK2G,RYR3
7.271e-04	-7.23	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	7	14470	45	ERBB4,DCLK2,TNIK,CAMK2G,PRKG1,NTRK2,MAPK10
7.565e-04	-7.19	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	48	SOX5,SLC4A4,CLU,LSAMP,RORA,HPSE2,MACF1,TRPM3,CST3,DCLK2,NRG3,PARD3,NTM,PRKG1,CAMK2G,DTNA,CTNND2,GPC5,NPAS3,NEBL,ADCY2,CDH20,TNC,NTRK2,SLC1A2,CNTN1,NRXN1,MSI2,NAV2,DGKG,ERBB4,GLIS3,TNIK,SORBS1,FMN2,PLCB1,GFAP,LRP1B,RYR3,ATP1A2,MGAT4C
7.616e-04	-7.18	kinase activity	molecular function	GO:0016301	739	8	18094	49	PRKG1,TNIK,CAMK2G,DCLK2,ERBB4,MAPK10,NTRK2,DGKG
7.697e-04	-7.17	phosphorylation	biological process	GO:0016310	729	8	18204	50	PRKG1,DCLK2,ERBB4,CAMK2G,DGKG,TNIK,NTRK2,MAPK10
8.047e-04	-7.13	cell migration	biological process	GO:0016477	921	9	18204	50	FMN2,ERBB4,GPC5,CDH20,CTNNA2,PRKG1,GPM6A,NRG3,NTRK2
8.087e-04	-7.12	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	2	10285	34	ERBB4,NRG3
8.118e-04	-7.12	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	3	10285	34	RYR3,CAMK2G,ATP1A2
8.309e-04	-7.09	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	5	19454	50	PARD3,PLCB1,SORBS1,NTRK2,DTNA
8.364e-04	-7.09	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	7	16828	48	NTRK2,FMN2,TNIK,PRKG1,CAMK2G,ERBB4,DCLK2
8.382e-04	-7.08	learning	biological process	GO:0007612	154	4	18204	50	ATP1A2,PLCB1,NTRK2,NRXN1
8.382e-04	-7.08	hindbrain development	biological process	GO:0030902	154	4	18204	50	CNTN1,RORA,CTNNA2,PRKG1
8.440e-04	-7.08	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	5	19454	50	PARD3,FMN2,NEBL,SORBS1,PRKG1
8.454e-04	-7.08	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	7	16828	48	CAMK2G,TNIK,FMN2,NTRK2,PRKG1,ERBB4,DCLK2
8.538e-04	-7.07	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	20	16828	48	ADCY2,ATP1A2,CTNND2,GPC5,NPAS3,RYR3,PRKG1,LRP1B,FMN2,PLCB1,PARD3,DCLK2,ERBB4,NAV2,DGKG,MACF1,HPSE2,TRPM3,CNTN1,SLC4A4
8.657e-04	-7.05	locomotory exploration behavior	biological process	GO:0035641	16	2	18204	50	ATP1A2,APOE
8.657e-04	-7.05	asymmetric cell division	biological process	GO:0008356	16	2	18204	50	SOX5,PARD3
8.683e-04	-7.05	protein kinase activity	molecular function	GO:0004672	577	7	18094	49	CAMK2G,NTRK2,TNIK,MAPK10,ERBB4,DCLK2,PRKG1
8.927e-04	-7.02	vascular process in circulatory system	biological process	GO:0003018	273	5	18204	50	SLC1A2,SLC4A4,PRKG1,APOE,ATP1A2
9.082e-04	-7.00	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	18	16828	48	MSI2,TRPM3,MACF1,SLC4A4,NTRK2,CNTN1,NRG3,ERBB4,NAV2,NPAS3,NTM,PARD3,FMN2,LRP1B,PRKG1,ADCY2,ATP1A2,NEBL
9.082e-04	-7.00	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	18	16828	48	NRG3,ERBB4,NAV2,MSI2,TRPM3,MACF1,SLC4A4,NTRK2,CNTN1,ADCY2,ATP1A2,NEBL,NPAS3,PARD3,NTM,FMN2,LRP1B,PRKG1
9.223e-04	-6.99	gliogenesis	biological process	GO:0042063	275	5	18204	50	CLU,GFAP,NTRK2,CNTN1,PARD3
9.341e-04	-6.98	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	5	16828	48	APOE,SOX5,LRP1B,RYR3,CDH20
9.374e-04	-6.97	learning or memory	biological process	GO:0007611	276	5	18204	50	NTRK2,NRXN1,PLCB1,APOE,ATP1A2
9.416e-04	-6.97	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	2	10285	34	NRG3,ERBB4
9.687e-04	-6.94	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	32	16828	48	MACF1,HPSE2,SOX5,LSAMP,CLU,ABLIM1,RORA,NRG3,RFX4,GPC5,CTNND2,PARD3,PRKG1,ADCY2,CDH20,NEBL,TNC,NTRK2,NKAIN3,SLC1A2,CNTN1,GLIS3,NAV2,DGKG,ERBB4,RYR3,PLCB1,FMN2,GPM6A,TNIK,LRP1B,MGAT4C
9.794e-04	-6.93	regulation of amyloid fibril formation	biological process	GO:1905906	17	2	18204	50	CLU,APOE
9.794e-04	-6.93	reverse cholesterol transport	biological process	GO:0043691	17	2	18204	50	APOE,CLU
9.802e-04	-6.93	axon development	biological process	GO:0061564	420	6	18204	50	TNC,PARD3,CNTN1,PRKG1,CTNNA2,NRXN1
1.043e-03	-6.87	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	12	16828	48	GPC5,RYR3,PRKG1,LRP1B,PLCB1,PARD3,ADCY2,HPSE2,TRPM3,NRG3,ERBB4,NAV2
1.048e-03	-6.86	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	9	16828	48	PLCB1,SORBS1,TNC,LRP1B,CTNND2,MACF1,MGAT4C,ERBB4,ADCY2
1.049e-03	-6.86	animal organ development	biological process	GO:0048513	2846	17	18204	50	RFX4,SLC1A2,PLCB1,NTRK2,TNC,ERBB4,NEBL,CNTN1,RORA,ATP1A2,ABLIM1,NRG3,PRKG1,CTNNA2,GPM6A,SOX5,DCLK2
1.069e-03	-6.84	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	2	18094	49	APOE,HPSE2
1.075e-03	-6.84	actin binding	molecular function	GO:0003779	434	6	18094	49	SORBS1,FMN2,ABLIM1,CTNNA2,NEBL,MACF1
1.084e-03	-6.83	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	2	10285	34	NRG3,ERBB4
1.088e-03	-6.82	dendrite	cellular component	GO:0030425	620	7	19108	50	ADCY2,NTRK2,CLU,CTNND2,GPM6A,ATP1A2,APOE
1.100e-03	-6.81	positive regulation of circadian rhythm	biological process	GO:0042753	18	2	18204	50	PRKG1,RORA
1.100e-03	-6.81	negative regulation of platelet activation	biological process	GO:0010544	18	2	18204	50	PRKG1,APOE
1.108e-03	-6.80	dendritic tree	cellular component	GO:0097447	622	7	19108	50	ATP1A2,GPM6A,APOE,CTNND2,CLU,NTRK2,ADCY2
1.114e-03	-6.80	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	8	16828	48	MACF1,PARD3,TNC,PLCB1,LRP1B,CDH20,NRG3,ERBB4
1.115e-03	-6.80	astrocyte projection	cellular component	GO:0097449	19	2	19108	50	SLC1A2,GFAP
1.155e-03	-6.76	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	5	19454	50	DTNA,PARD3,SORBS1,NRXN1,MACF1
1.181e-03	-6.74	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	6	18094	49	SLC1A2,GPM6A,RYR3,ATP1A2,SLC4A4,TRPM3
1.194e-03	-6.73	cytoskeletal protein binding	molecular function	GO:0008092	989	9	18094	49	MACF1,NEBL,CTNNA2,DCLK2,ABLIM1,SORBS1,CLU,FMN2,APOE
1.227e-03	-6.70	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	2	18204	50	APOE,PRKG1
1.227e-03	-6.70	regulation of amyloid-beta clearance	biological process	GO:1900221	19	2	18204	50	CLU,APOE
1.227e-03	-6.70	regulation of neurotransmitter uptake	biological process	GO:0051580	19	2	18204	50	GFAP,ATP1A2
1.237e-03	-6.70	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	2	10285	34	NRG3,ERBB4
1.237e-03	-6.70	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	2	10285	34	ERBB4,NRG3
1.243e-03	-6.69	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	2	5310	22	RYR3,PLCB1
1.245e-03	-6.69	MAPK9 (mitogen-activated protein kinase 9)	protein interactions	5601	183	4	19454	50	CLU,MAPK10,MACF1,GFAP
1.255e-03	-6.68	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	11	19454	50	APOE,CST3,MAPK10,PLCB1,CTNNA2,MGAT4C,NTRK2,GFAP,SLC1A2,ADCY2,TNC
1.283e-03	-6.66	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	50	NTRK2,SLC1A2,GFAP
1.289e-03	-6.65	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	6	18204	50	NRXN1,CNTN1,PARD3,CTNND2,PRKG1,CTNNA2
1.293e-03	-6.65	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	9	16828	48	GPC5,MACF1,TRPM3,CNTN1,LRP1B,TNC,FMN2,SLC1A2,PARD3
1.293e-03	-6.65	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	9	16828	48	PARD3,SLC1A2,TNC,FMN2,LRP1B,CNTN1,TRPM3,MACF1,GPC5
1.298e-03	-6.65	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	8	16828	48	CAMK2G,TNIK,NTRK2,LRP1B,PRKG1,CDH20,ERBB4,DCLK2
1.298e-03	-6.65	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	8	16828	48	NTRK2,TNIK,PRKG1,LRP1B,CAMK2G,ERBB4,DCLK2,CDH20
1.316e-03	-6.63	signal transduction	biological process	GO:0007165	4637	23	18204	50	CLU,RYR3,FMN2,APOE,DGKG,TNIK,ERBB4,SORBS1,ATP1A2,RORA,NRG3,MAPK10,CTNND2,MACF1,PRKG1,DCLK2,PARD3,PITPNC1,NTRK2,DTNA,PLCB1,ADCY2,CNTN1
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	SORBS1,MACF1
1.318e-03	-6.63	SHC4 (SHC adaptor protein 4)	protein interactions	399694	21	2	19454	50	NTRK2,ERBB4
1.324e-03	-6.63	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	7	12186	43	TNIK,PRKG1,ERBB4,NTRK2,CAMK2G,DCLK2,MAPK10
1.326e-03	-6.63	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	8	10285	34	RYR3,SLC4A4,CAMK2G,SLC1A2,ATP1A2,TRPM3,ADCY2,SLC14A1
1.330e-03	-6.62	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	6	16828	48	DCLK2,ERBB4,CAMK2G,PRKG1,NTRK2,TNIK
1.330e-03	-6.62	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	6	16828	48	DCLK2,ERBB4,PRKG1,NTRK2,TNIK,CAMK2G
1.361e-03	-6.60	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	50	SLC1A2,GFAP
1.380e-03	-6.59	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	32	16828	48	DCLK2,CST3,NRG3,RORA,ABLIM1,SOX5,SLC4A4,TRPM3,MACF1,NEBL,ADCY2,PRKG1,PARD3,NPAS3,CTNND2,DTNA,CAMK2G,ERBB4,DGKG,NAV2,GLIS3,CNTN1,TNC,NKAIN3,NTRK2,NRXN1,ATP1A2,LRP1B,FMN2,SORBS1,TNIK,RYR3
1.394e-03	-6.58	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	12	16828	48	ATP1A2,GPC5,PRKG1,PLCB1,GFAP,MACF1,NRXN1,CNTN1,LSAMP,RORA,SLC4A4,SOX5
1.414e-03	-6.56	Ser/Thr_kinase_AS	interpro domains	IPR008271	308	5	18521	50	MAPK10,CAMK2G,DCLK2,PRKG1,TNIK
1.427e-03	-6.55	somatodendritic compartment	cellular component	GO:0036477	842	8	19108	50	CTNND2,NRXN1,GPM6A,ATP1A2,APOE,ADCY2,NTRK2,CLU
1.429e-03	-6.55	axon	cellular component	GO:0030424	650	7	19108	50	NTRK2,SLC1A2,GPM6A,DTNA,CNTN1,PARD3,CTNNA2
1.431e-03	-6.55	regulation of amide metabolic process	biological process	GO:0034248	81	3	18204	50	CLU,APOE,NTRK2
1.473e-03	-6.52	leg	COSMIC cancer mutations	leg	969	9	16828	48	NEBL,NRG3,LRP1B,PRKG1,CNTN1,SLC4A4,NTM,PLCB1,FMN2
1.481e-03	-6.52	stress fiber	cellular component	GO:0001725	86	3	19108	50	SORBS1,ABLIM1,NEBL
1.481e-03	-6.52	contractile actin filament bundle	cellular component	GO:0097517	86	3	19108	50	ABLIM1,NEBL,SORBS1
1.495e-03	-6.51	EF-hand	gene3d domains	1.10.238.10	272	5	14470	45	DGKG,PLCB1,DTNA,MACF1,RYR3
1.545e-03	-6.47	synaptic signaling	biological process	GO:0099536	459	6	18204	50	APOE,SLC1A2,DTNA,PLCB1,NRXN1,NTRK2
1.546e-03	-6.47	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	298	5	16828	48	ATP1A2,FMN2,TNC,LRP1B,CTNND2
1.548e-03	-6.47	SFN (stratifin)	protein interactions	2810	671	7	19454	50	SORBS1,PARD3,ABLIM1,NAV2,TNIK,MACF1,FMN2
1.571e-03	-6.46	ATP binding	molecular function	GO:0005524	1467	11	18094	49	ERBB4,DCLK2,NTRK2,DGKG,MAPK10,NAV2,ATP1A2,PRKG1,ADCY2,CAMK2G,TNIK
1.578e-03	-6.45	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	9	19454	50	ABLIM1,CAMK2G,NAV2,MACF1,DCLK2,FMN2,PITPNC1,SORBS1,PARD3
1.582e-03	-6.45	TIMM10B (translocase of inner mitochondrial membrane 10B)	protein interactions	26515	23	2	19454	50	HPSE2,MSI2
1.587e-03	-6.45	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	4	18204	50	SLC4A4,SORBS1,PRKG1,RORA
1.589e-03	-6.44	regulation of sodium ion transport	biological process	GO:0002028	84	3	18204	50	CNTN1,ATP1A2,NKAIN3
1.597e-03	-6.44	protein localization to membrane	biological process	GO:0072657	462	6	18204	50	TNIK,ERBB4,NRXN1,PARD3,MACF1,APOE
1.603e-03	-6.44	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	41	16828	48	ATP1A2,MGAT4C,RYR3,LRP1B,GFAP,SORBS1,PLCB1,TNIK,FMN2,GLIS3,ERBB4,DGKG,NAV2,MSI2,NRXN1,CNTN1,SLC1A2,TNC,NTRK2,CDH20,ADCY2,NEBL,NPAS3,GPC5,CTNND2,DTNA,CAMK2G,PRKG1,PARD3,NTM,NRG3,DCLK2,CST3,TRPM3,HPSE2,MACF1,RORA,LSAMP,CLU,SOX5,SLC4A4
1.621e-03	-6.42	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	12	18204	50	ADCY2,ERBB4,PLCB1,TNIK,NTRK2,DGKG,PRKG1,DCLK2,CAMK2G,RORA,ATP1A2,MAPK10
1.644e-03	-6.41	oligodendrocyte differentiation	biological process	GO:0048709	85	3	18204	50	CLU,CNTN1,NTRK2
1.649e-03	-6.41	negative regulation of muscle contraction	biological process	GO:0045932	22	2	18204	50	PRKG1,ATP1A2
1.655e-03	-6.40	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	3	19454	50	GPM6A,NTM,CNTN1
1.663e-03	-6.40	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	22	16828	48	CDH20,ADCY2,PRKG1,PARD3,NTM,CTNND2,RFX4,NRG3,SOX5,SLC4A4,MACF1,HPSE2,TRPM3,LRP1B,GPM6A,TNIK,FMN2,PLCB1,SORBS1,RYR3,CNTN1,NTRK2
1.664e-03	-6.40	cell-cell signaling	biological process	GO:0007267	822	8	18204	50	APOE,PLCB1,SLC1A2,DTNA,NTRK2,NRXN1,TNC,CAMK2G
1.700e-03	-6.38	vascular transport	biological process	GO:0010232	86	3	18204	50	SLC4A4,SLC1A2,ATP1A2
1.700e-03	-6.38	transport across blood-brain barrier	biological process	GO:0150104	86	3	18204	50	SLC4A4,SLC1A2,ATP1A2
1.705e-03	-6.37	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	12	18204	50	ERBB4,NTRK2,PLCB1,APOE,SOX5,PARD3,MACF1,NRXN1,CLU,GFAP,RORA,ATP1A2
1.779e-03	-6.33	cognition	biological process	GO:0050890	319	5	18204	50	NRXN1,NTRK2,PLCB1,APOE,ATP1A2
1.793e-03	-6.32	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	6	16828	48	CAMK2G,ERBB4,TNIK,NTRK2,DCLK2,PRKG1
1.797e-03	-6.32	actomyosin	cellular component	GO:0042641	92	3	19108	50	SORBS1,ABLIM1,NEBL
1.800e-03	-6.32	amyloid-beta binding	molecular function	GO:0001540	89	3	18094	49	APOE,CST3,CLU
1.803e-03	-6.32	relaxation of muscle	biological process	GO:0090075	23	2	18204	50	PRKG1,ATP1A2
1.813e-03	-6.31	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	4	16828	48	LRP1B,RYR3,GPC5,NRG3
1.833e-03	-6.30	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	6	16828	48	TNIK,NTRK2,PRKG1,CAMK2G,ERBB4,DCLK2
1.848e-03	-6.29	phosphorus metabolic process	biological process	GO:0006793	1707	12	18204	50	DGKG,TNIK,NTRK2,PLCB1,ADCY2,ERBB4,RORA,ATP1A2,MAPK10,PRKG1,DCLK2,CAMK2G
1.870e-03	-6.28	TNC (tenascin C)	protein interactions	3371	25	2	19454	50	CLU,CNTN1
1.909e-03	-6.26	low-density lipoprotein particle receptor binding	molecular function	GO:0050750	24	2	18094	49	APOE,CLU
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr10q11.23-q21.1	chromosome location	human chr10q11.23-q21.1	1	1	26134	50	PRKG1
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr12q21.31-q21.32	chromosome location	human chr12q21.31-q21.32	1	1	26134	50	MGAT4C
1.913e-03	-6.26	human chr3q27.2-q27.3	chromosome location	human chr3q27.2-q27.3	1	1	26134	50	DGKG
1.913e-03	-6.26	human chr10p11.22-p11.21	chromosome location	human chr10p11.22-p11.21	1	1	26134	50	PARD3
1.913e-03	-6.26	human chr4q31.23-q31.3	chromosome location	human chr4q31.23-q31.3	1	1	26134	50	DCLK2
1.913e-03	-6.26	human chr2q22.1-q22.2	chromosome location	human chr2q22.1-q22.2	1	1	26134	50	LRP1B
1.950e-03	-6.24	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	6	12186	43	TNIK,PRKG1,ERBB4,NTRK2,CAMK2G,DCLK2
1.957e-03	-6.24	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	6	16828	48	NTRK2,TNIK,PRKG1,CAMK2G,ERBB4,DCLK2
1.987e-03	-6.22	carbohydrate derivative binding	molecular function	GO:0097367	2251	14	18094	49	MAPK10,NAV2,NTRK2,DCLK2,TNC,ADCY2,PRKG1,ATP1A2,APOE,DGKG,ERBB4,HPSE2,TNIK,CAMK2G
2.026e-03	-6.20	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	11	16828	48	NRXN1,RYR3,CTNND2,MACF1,FMN2,CNTN1,LRP1B,RFX4,CDH20,NAV2,NEBL
2.026e-03	-6.20	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	11	16828	48	CNTN1,LRP1B,FMN2,MACF1,CTNND2,RYR3,NRXN1,NAV2,NEBL,RFX4,CDH20
2.030e-03	-6.20	actin filament bundle	cellular component	GO:0032432	96	3	19108	50	SORBS1,NEBL,ABLIM1
2.035e-03	-6.20	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	10	16828	48	ATP1A2,ERBB4,ADCY2,TNC,PLCB1,LRP1B,CNTN1,TRPM3,CTNND2,GPC5
2.047e-03	-6.19	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	3	19454	50	PARD3,NTRK2,SORBS1
2.047e-03	-6.19	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	3	19454	50	CNTN1,LSAMP,GPM6A
2.049e-03	-6.19	localization	biological process	GO:0051179	4474	22	18204	50	ATP1A2,SLC14A1,GPM6A,MACF1,PARD3,CAMK2G,DCLK2,PLCB1,PITPNC1,NTRK2,SLC4A4,TRPM3,GFAP,CLU,NRXN1,RYR3,FMN2,APOE,SLC1A2,TNIK,LRP1B,ERBB4
2.055e-03	-6.19	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	41	16828	48	SLC14A1,NRG3,RFX4,DCLK2,TRPM3,HPSE2,MACF1,RORA,ABLIM1,LSAMP,SLC4A4,SOX5,CDH20,ADCY2,NEBL,NPAS3,CTNND2,GPC5,DTNA,CAMK2G,PRKG1,NTM,PARD3,GLIS3,NAV2,DGKG,ERBB4,MSI2,NRXN1,CNTN1,SLC1A2,NTRK2,TNC,NKAIN3,ATP1A2,RYR3,LRP1B,GFAP,FMN2,PLCB1,TNIK
2.077e-03	-6.18	locomotory behavior	biological process	GO:0007626	197	4	18204	50	NAV2,ATP1A2,APOE,CNTN1
2.090e-03	-6.17	regulation of small molecule metabolic process	biological process	GO:0062012	331	5	18204	50	PRKG1,RORA,APOE,SORBS1,SLC4A4
2.095e-03	-6.17	high-density lipoprotein particle	cellular component	GO:0034364	26	2	19108	50	APOE,CLU
2.123e-03	-6.16	cell-cell junction	cellular component	GO:0005911	513	6	19108	50	ATP1A2,CTNND2,SORBS1,PARD3,CDH20,CTNNA2
2.132e-03	-6.15	establishment of localization	biological process	GO:0051234	3887	20	18204	50	SLC14A1,GPM6A,MACF1,RYR3,FMN2,PARD3,CAMK2G,GFAP,ATP1A2,CLU,NRXN1,LRP1B,SLC4A4,TRPM3,ERBB4,APOE,SLC1A2,PLCB1,PITPNC1,NTRK2
2.136e-03	-6.15	neck	COSMIC cancer mutations	neck	1231	10	16828	48	LRP1B,CNTN1,PLCB1,TNC,TRPM3,CTNND2,GPC5,ATP1A2,ERBB4,ADCY2
2.141e-03	-6.15	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	5	16828	48	ATP1A2,FMN2,TNC,LRP1B,CTNND2
2.142e-03	-6.15	HS-GAG degradation	REACTOME pathways	R-HSA-2024096	21	2	10285	34	GPC5,HPSE2
2.176e-03	-6.13	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	11	18094	49	DGKG,NTRK2,NAV2,MAPK10,ERBB4,DCLK2,CAMK2G,ADCY2,TNIK,ATP1A2,PRKG1
2.178e-03	-6.13	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	5	19454	50	TNIK,MACF1,NEBL,SORBS1,PARD3
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	DTNA,ABLIM1
2.189e-03	-6.12	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	22	19454	50	DCLK2,NTM,LSAMP,CTNNA2,PARD3,CLU,MACF1,TNIK,TNC,CTNND2,DTNA,CAMK2G,CNTN1,GFAP,PLCB1,PITPNC1,ATP1A2,MSI2,CST3,GPM6A,SLC4A4,APOE
2.253e-03	-6.10	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	48	16828	48	NRG3,RFX4,CST3,MACF1,HPSE2,CLU,LSAMP,RORA,NEBL,CAMK2G,DTNA,GPC5,NTM,PRKG1,GLIS3,NAV2,ERBB4,NRXN1,TNC,NKAIN3,APOE,SLC1A2,PITPNC1,ATP1A2,TNIK,PLCB1,LRP1B,SLC14A1,DCLK2,TRPM3,SOX5,SLC4A4,ABLIM1,ADCY2,CDH20,CTNND2,NPAS3,PARD3,DGKG,MSI2,NTRK2,CNTN1,MGAT4C,RYR3,FMN2,SORBS1,GPM6A,GFAP
2.272e-03	-6.09	actin cytoskeleton	cellular component	GO:0015629	520	6	19108	50	CTNNA2,ABLIM1,NEBL,FMN2,MACF1,SORBS1
2.275e-03	-6.09	transport	biological process	GO:0006810	3615	19	18204	50	NRXN1,CLU,ATP1A2,GFAP,CAMK2G,FMN2,GPM6A,MACF1,RYR3,SLC14A1,PITPNC1,NTRK2,SLC1A2,PLCB1,APOE,TRPM3,ERBB4,SLC4A4,LRP1B
2.281e-03	-6.08	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	50	DTNA,CTNNA2,CDH20
2.304e-03	-6.07	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	50	SLC1A2,GFAP
2.304e-03	-6.07	central nervous system myelination	biological process	GO:0022010	26	2	18204	50	CNTN1,CLU
2.304e-03	-6.07	axon ensheathment in central nervous system	biological process	GO:0032291	26	2	18204	50	CLU,CNTN1
2.321e-03	-6.07	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	4	19454	50	RORA,ABLIM1,NKAIN3,GFAP
2.351e-03	-6.05	SHC1 events in ERBB2 signaling	REACTOME pathways	R-HSA-1250196	22	2	10285	34	ERBB4,NRG3
2.370e-03	-6.05	YES1 (YES proto-oncogene 1, Src family tyrosine kinase)	protein interactions	7525	364	5	19454	50	CAMK2G,MSI2,ERBB4,SLC14A1,GFAP
2.399e-03	-6.03	calcium ion transmembrane transport	biological process	GO:0070588	205	4	18204	50	RYR3,GPM6A,TRPM3,PLCB1
2.424e-03	-6.02	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	3	19454	50	SORBS1,CLU,ABLIM1
2.455e-03	-6.01	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	5	19454	50	PARD3,NTRK2,TNIK,ABLIM1,CLU
2.484e-03	-6.00	protein kinase C-activating G protein-coupled receptor signaling pathway	biological process	GO:0007205	27	2	18204	50	PARD3,DGKG
2.496e-03	-5.99	system process	biological process	GO:0003008	2015	13	18204	50	ABLIM1,NRXN1,ATP1A2,NAV2,PRKG1,CTNNA2,RYR3,PLCB1,DTNA,SLC1A2,NTRK2,APOE,SLC4A4
2.499e-03	-5.99	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	21	16828	48	SLC1A2,SLC4A4,TNC,ABLIM1,RORA,CNTN1,MACF1,NAV2,ERBB4,RFX4,NRG3,PARD3,FMN2,PLCB1,LRP1B,CTNND2,GPC5,MGAT4C,ATP1A2,NEBL,CDH20
2.514e-03	-5.99	PLEKHA6 (pleckstrin homology domain containing A6)	protein interactions	22874	29	2	19454	50	APOE,PARD3
2.519e-03	-5.98	Adrenergic signaling in cardiomyocytes	KEGG pathways	hsa04261	144	4	7161	29	CAMK2G,PLCB1,ATP1A2,ADCY2
2.519e-03	-5.98	Adrenergic signaling in cardiomyocytes	KEGG pathways	ko04261	144	4	7161	29	ADCY2,ATP1A2,PLCB1,CAMK2G
2.520e-03	-5.98	PSEN1 (presenilin 1)	protein interactions	5663	222	4	19454	50	APOE,DTNA,CTNND2,GFAP
2.526e-03	-5.98	actin filament binding	molecular function	GO:0051015	211	4	18094	49	ABLIM1,CTNNA2,MACF1,NEBL
2.570e-03	-5.96	Cntnap2 (contactin associated protein-like 2)	protein interactions	66797	1	1	19454	50	CNTN1
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	App (amyloid beta precursor protein)	protein interactions	100689222	1	1	19454	50	LRP1B
2.570e-03	-5.96	IML3 (Iml3p)	protein interactions	852404	1	1	19454	50	GFAP
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Itga7 (integrin subunit alpha 7)	protein interactions	81008	1	1	19454	50	TNC
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	Sytl1 (synaptotagmin-like 1)	protein interactions	269589	1	1	19454	50	NRXN1
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.573e-03	-5.96	circulatory system process	biological process	GO:0003013	508	6	18204	50	SLC4A4,PRKG1,SLC1A2,NAV2,ATP1A2,APOE
2.585e-03	-5.96	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	11	16828	48	SLC14A1,NRG3,DGKG,MACF1,RYR3,DTNA,GPC5,NPAS3,SORBS1,FMN2,LRP1B
2.585e-03	-5.96	Pkinase	pfam domains	PF00069	347	5	17795	49	DCLK2,PRKG1,MAPK10,TNIK,CAMK2G
2.603e-03	-5.95	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	4	19454	50	ABLIM1,GPM6A,NAV2,MACF1
2.617e-03	-5.95	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	50	CLU
2.620e-03	-5.94	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	7	16828	48	LRP1B,PRKG1,TNIK,NTRK2,CAMK2G,DCLK2,ERBB4
2.647e-03	-5.93	organelle organization	biological process	GO:0006996	3091	17	18204	50	DCLK2,FMN2,PARD3,MACF1,CTNNA2,PRKG1,NRXN1,ABLIM1,NAV2,SORBS1,CLU,GFAP,ERBB4,NEBL,TNIK,RFX4,APOE
2.670e-03	-5.93	glial cell proliferation	biological process	GO:0014009	28	2	18204	50	GFAP,CLU
2.677e-03	-5.92	central_nervous_system-brainstem-glioma	COSMIC cancer mutations	central_nervous_system-brainstem-glioma	338	5	16828	48	LRP1B,ERBB4,TNC,GPC5,HPSE2
2.698e-03	-5.92	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	3	19454	50	MSI2,ERBB4,RYR3
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	C1_DGKgamma_rpt2	interpro domains	IPR047475	1	1	18521	50	DGKG
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	Contactin-1_Ig6	interpro domains	IPR047101	1	1	18521	50	CNTN1
2.700e-03	-5.91	Contactin-1_Ig1	interpro domains	IPR036992	1	1	18521	50	CNTN1
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	Contactin-1_Ig3	interpro domains	IPR047100	1	1	18521	50	CNTN1
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	PLC-beta1_EF	interpro domains	IPR028400	1	1	18521	50	PLCB1
2.700e-03	-5.91	PKcGMP_CC	interpro domains	IPR031831	1	1	18521	50	PRKG1
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.708e-03	-5.91	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	49	NTRK2
2.708e-03	-5.91	metal chelating activity	molecular function	GO:0046911	1	1	18094	49	APOE
2.709e-03	-5.91	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	7	16828	48	DCLK2,ERBB4,PRKG1,LRP1B,NTRK2,TNIK,CAMK2G
2.724e-03	-5.91	transferase activity, transferring phosphorus-containing groups	molecular function	GO:0016772	903	8	18094	49	DGKG,NTRK2,MAPK10,ERBB4,DCLK2,CAMK2G,TNIK,PRKG1
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	50	NTRK2
2.747e-03	-5.90	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	50	APOE
2.747e-03	-5.90	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	50	CST3
2.747e-03	-5.90	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	50	FMN2
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.747e-03	-5.90	response to glyceraldehyde	biological process	GO:1905630	1	1	18204	50	PLCB1
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	50	NTRK2
2.747e-03	-5.90	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	50	APOE
2.747e-03	-5.90	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	50	NRG3
2.747e-03	-5.90	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	50	APOE
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.747e-03	-5.90	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	50	APOE
2.747e-03	-5.90	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	50	APOE
2.747e-03	-5.90	regulation of CD24 production	biological process	GO:2000559	1	1	18204	50	PLCB1
2.747e-03	-5.90	cellular response to glyceraldehyde	biological process	GO:1905631	1	1	18204	50	PLCB1
2.747e-03	-5.90	positive regulation of CD24 production	biological process	GO:2000560	1	1	18204	50	PLCB1
2.747e-03	-5.90	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	50	APOE
2.747e-03	-5.90	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	50	CLU
2.747e-03	-5.90	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	50	CLU
2.747e-03	-5.90	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	50	APOE
2.747e-03	-5.90	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	50	CST3
2.747e-03	-5.90	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	50	NRG3
2.747e-03	-5.90	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	50	APOE
2.754e-03	-5.89	PKcGMP_CC	pfam domains	PF16808	1	1	17795	49	PRKG1
2.777e-03	-5.89	cell motility	biological process	GO:0048870	1101	9	18204	50	FMN2,GPC5,ERBB4,CTNNA2,PRKG1,CDH20,GPM6A,NRG3,NTRK2
2.784e-03	-5.88	lipoprotein particle receptor binding	molecular function	GO:0070325	29	2	18094	49	CLU,APOE
2.837e-03	-5.86	Bile secretion	KEGG pathways	hsa04976	71	3	7161	29	ADCY2,ATP1A2,SLC4A4
2.837e-03	-5.86	Bile secretion	KEGG pathways	ko04976	71	3	7161	29	ATP1A2,ADCY2,SLC4A4
2.843e-03	-5.86	cerebellum development	biological process	GO:0021549	103	3	18204	50	CNTN1,RORA,PRKG1
2.863e-03	-5.86	postsynaptic membrane organization	biological process	GO:0001941	29	2	18204	50	APOE,NRXN1
2.863e-03	-5.86	myelination in peripheral nervous system	biological process	GO:0022011	29	2	18204	50	NTRK2,PARD3
2.863e-03	-5.86	cGMP-mediated signaling	biological process	GO:0019934	29	2	18204	50	APOE,PRKG1
2.863e-03	-5.86	peripheral nervous system axon ensheathment	biological process	GO:0032292	29	2	18204	50	PARD3,NTRK2
2.863e-03	-5.86	DST (dystonin)	protein interactions	667	230	4	19454	50	ATP1A2,PARD3,TNIK,NTRK2
2.870e-03	-5.85	RYR1 (ryanodine receptor 1)	protein interactions	6261	31	2	19454	50	PRKG1,CAMK2G
2.870e-03	-5.85	SH2B1 (SH2B adaptor protein 1)	protein interactions	25970	31	2	19454	50	ERBB4,NTRK2
2.870e-03	-5.85	SH2D1B (SH2 domain containing 1B)	protein interactions	117157	31	2	19454	50	ABLIM1,ERBB4
2.888e-03	-5.85	protein serine kinase activity	molecular function	GO:0106310	362	5	18094	49	MAPK10,TNIK,CAMK2G,PRKG1,DCLK2
2.897e-03	-5.84	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	8	16828	48	ERBB4,DCLK2,CAMK2G,MACF1,TNIK,NTRK2,CNTN1,PRKG1
2.901e-03	-5.84	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	6	16828	48	DCLK2,ERBB4,PRKG1,TNIK,NTRK2,CAMK2G
2.922e-03	-5.84	regulation of steroid metabolic process	biological process	GO:0019218	104	3	18204	50	RORA,APOE,PRKG1
2.934e-03	-5.83	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	7	18094	49	SLC4A4,TRPM3,RYR3,ATP1A2,SLC14A1,SLC1A2,GPM6A
2.952e-03	-5.83	Adherens junction	KEGG pathways	ko04520	72	3	7161	29	PARD3,CTNNA2,SORBS1
2.952e-03	-5.83	Adherens junction	KEGG pathways	hsa04520	72	3	7161	29	CTNNA2,SORBS1,PARD3
2.973e-03	-5.82	catenin complex	cellular component	GO:0016342	31	2	19108	50	CDH20,CTNNA2
2.985e-03	-5.81	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	4	16828	48	PRKG1,LRP1B,NTM,SLC4A4
2.986e-03	-5.81	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	27	16828	48	SOX5,SLC4A4,RORA,ABLIM1,TRPM3,MACF1,CST3,DCLK2,NRG3,PARD3,CAMK2G,DTNA,NPAS3,CTNND2,NEBL,ADCY2,NKAIN3,NTRK2,TNC,CNTN1,DGKG,ERBB4,NAV2,GLIS3,LRP1B,RYR3,ATP1A2
2.993e-03	-5.81	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	8	19454	50	CAMK2G,ABLIM1,NAV2,MACF1,DCLK2,PITPNC1,SORBS1,PARD3
3.041e-03	-5.80	positive regulation of cell projection organization	biological process	GO:0031346	361	5	18204	50	CNTN1,NTRK2,APOE,MACF1,GPM6A
3.041e-03	-5.80	regulation of protein catabolic process	biological process	GO:0042176	361	5	18204	50	FMN2,APOE,GFAP,CST3,CLU
3.062e-03	-5.79	neuron projection regeneration	biological process	GO:0031102	30	2	18204	50	GFAP,TNC
3.062e-03	-5.79	neurotransmitter uptake	biological process	GO:0001504	30	2	18204	50	ATP1A2,SLC1A2
3.065e-03	-5.79	Oxytocin signaling pathway	KEGG pathways	hsa04921	152	4	7161	29	RYR3,CAMK2G,ADCY2,PLCB1
3.065e-03	-5.79	Oxytocin signaling pathway	KEGG pathways	ko04921	152	4	7161	29	PLCB1,ADCY2,CAMK2G,RYR3
3.076e-03	-5.78	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	6	16828	48	TNIK,NTRK2,PRKG1,CAMK2G,ERBB4,DCLK2
3.093e-03	-5.78	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	4	19454	50	DTNA,MACF1,NTRK2,PARD3
3.110e-03	-5.77	-	gene3d domains	6.10.250.880	1	1	14470	45	ERBB4
3.145e-03	-5.76	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	47	16828	48	DCLK2,SLC14A1,ABLIM1,SLC4A4,SOX5,TRPM3,CDH20,ADCY2,PARD3,CTNND2,NPAS3,DGKG,CNTN1,NTRK2,MGAT4C,SORBS1,FMN2,GPM6A,GFAP,RYR3,CST3,NRG3,RFX4,CLU,LSAMP,RORA,HPSE2,MACF1,NEBL,PRKG1,NTM,GPC5,DTNA,CAMK2G,ERBB4,NAV2,GLIS3,TNC,APOE,NKAIN3,SLC1A2,NRXN1,PITPNC1,ATP1A2,LRP1B,PLCB1,TNIK
3.188e-03	-5.75	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	4	19454	50	SOX5,GFAP,GPM6A,CAMK2G
3.188e-03	-5.75	CLU (clusterin)	protein interactions	1191	237	4	19454	50	TNC,CLU,LRP1B,TNIK
3.192e-03	-5.75	Thyroid hormone synthesis	KEGG pathways	ko04918	74	3	7161	29	ADCY2,ATP1A2,PLCB1
3.192e-03	-5.75	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	3	7161	29	ATP1A2,ADCY2,PLCB1
3.220e-03	-5.74	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	39	16828	48	SOX5,SLC4A4,LSAMP,ABLIM1,RORA,HPSE2,MACF1,TRPM3,NRG3,RFX4,SLC14A1,NTM,PARD3,PRKG1,CAMK2G,CTNND2,GPC5,NPAS3,NEBL,ADCY2,CDH20,TNC,NTRK2,NKAIN3,SLC1A2,CNTN1,NRXN1,MSI2,DGKG,NAV2,ERBB4,GLIS3,TNIK,FMN2,PLCB1,GFAP,LRP1B,RYR3,ATP1A2
3.220e-03	-5.74	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	39	16828	48	NEBL,CDH20,ADCY2,PRKG1,PARD3,NTM,NPAS3,GPC5,CTNND2,CAMK2G,SLC14A1,NRG3,RFX4,ABLIM1,RORA,LSAMP,SOX5,SLC4A4,TRPM3,MACF1,HPSE2,ATP1A2,LRP1B,GFAP,PLCB1,FMN2,TNIK,RYR3,NAV2,ERBB4,DGKG,GLIS3,CNTN1,SLC1A2,NKAIN3,TNC,NTRK2,NRXN1,MSI2
3.225e-03	-5.74	axonogenesis	biological process	GO:0007409	366	5	18204	50	PRKG1,CTNNA2,NRXN1,CNTN1,PARD3
3.249e-03	-5.73	TRPC3 (transient receptor potential cation channel subfamily C member 3)	protein interactions	7222	33	2	19454	50	PLCB1,PRKG1
3.249e-03	-5.73	VLDLR (very low density lipoprotein receptor)	protein interactions	7436	33	2	19454	50	APOE,CLU
3.253e-03	-5.73	extracellular matrix	cellular component	GO:0031012	559	6	19108	50	CLU,NAV2,GPC5,HPSE2,TNC,APOE
3.253e-03	-5.73	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	14	16828	48	CTNND2,FMN2,LRP1B,ATP1A2,HPSE2,TRPM3,NTRK2,TNC,SOX5,SLC1A2,CNTN1,RFX4,NRG3,DGKG
3.259e-03	-5.73	caecum	COSMIC cancer mutations	caecum	14248	47	16828	48	TRPM3,ABLIM1,SOX5,SLC4A4,SLC14A1,DCLK2,NPAS3,CTNND2,PARD3,CDH20,ADCY2,CNTN1,NTRK2,DGKG,RYR3,GFAP,FMN2,SORBS1,GPM6A,MGAT4C,HPSE2,MACF1,RORA,CLU,LSAMP,RFX4,NRG3,CST3,GPC5,CAMK2G,DTNA,PRKG1,NTM,NEBL,NRXN1,SLC1A2,NKAIN3,APOE,TNC,GLIS3,ERBB4,NAV2,LRP1B,PLCB1,TNIK,ATP1A2,PITPNC1
3.282e-03	-5.72	external encapsulating structure	cellular component	GO:0030312	560	6	19108	50	CLU,APOE,TNC,NAV2,HPSE2,GPC5
3.291e-03	-5.72	atypical	COSMIC cancer mutations	atypical	515	6	16828	48	ERBB4,DCLK2,TNIK,NTRK2,PRKG1,CAMK2G
3.329e-03	-5.71	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	10	16828	48	MACF1,NPAS3,TRPM3,LRP1B,SORBS1,NTM,SLC4A4,NAV2,ATP1A2,ERBB4
3.336e-03	-5.70	postsynapse organization	biological process	GO:0099173	109	3	18204	50	NRXN1,CTNND2,APOE
3.371e-03	-5.69	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	9	19454	50	MACF1,DCLK2,FMN2,ABLIM1,CAMK2G,NAV2,SORBS1,PARD3,PITPNC1
3.404e-03	-5.68	cellular response to endogenous stimulus	biological process	GO:0071495	1135	9	18204	50	SLC1A2,PLCB1,NTRK2,ATP1A2,SORBS1,TNC,SOX5,ERBB4,RYR3
3.441e-03	-5.67	HAX1 (HCLS1 associated protein X-1)	protein interactions	10456	397	5	19454	50	CLU,MAPK10,GPM6A,CNTN1,NTM
3.442e-03	-5.67	adenyl nucleotide binding	molecular function	GO:0030554	1620	11	18094	49	ATP1A2,PRKG1,CAMK2G,ADCY2,TNIK,ERBB4,DCLK2,DGKG,NTRK2,NAV2,MAPK10
3.444e-03	-5.67	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	18	NTRK2
3.485e-03	-5.66	seminoma	COSMIC cancer mutations	seminoma	700	7	16828	48	DCLK2,CNTN1,PRKG1,ERBB4,NTRK2,TNIK,CAMK2G
3.519e-03	-5.65	EGF-like_dom	interpro domains	IPR000742	232	4	18521	50	NRG3,NRXN1,TNC,LRP1B
3.529e-03	-5.65	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	43	CLU
3.529e-03	-5.65	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	43	CLU
3.659e-03	-5.61	tat (Tat)	protein interactions	155871	1718	11	19454	50	SORBS1,RYR3,SLC1A2,GFAP,SLC14A1,PLCB1,APOE,ADCY2,TNC,CAMK2G,PRKG1
3.692e-03	-5.60	dendrite development	biological process	GO:0016358	113	3	18204	50	CTNND2,CTNNA2,PRKG1
3.692e-03	-5.60	metencephalon development	biological process	GO:0022037	113	3	18204	50	RORA,PRKG1,CNTN1
3.697e-03	-5.60	response to auditory stimulus	biological process	GO:0010996	33	2	18204	50	NRXN1,ATP1A2
3.774e-03	-5.58	localization within membrane	biological process	GO:0051668	549	6	18204	50	PARD3,ERBB4,NRXN1,TNIK,APOE,MACF1
3.775e-03	-5.58	arm	COSMIC cancer mutations	arm	1331	10	16828	48	ATP1A2,ERBB4,NAV2,LRP1B,NTM,SLC4A4,SORBS1,NPAS3,TRPM3,MACF1
3.785e-03	-5.58	regulation of circadian rhythm	biological process	GO:0042752	114	3	18204	50	MAPK10,PRKG1,RORA
3.801e-03	-5.57	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	29	ATP1A2,SLC4A4
3.801e-03	-5.57	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	29	SLC4A4,ATP1A2
3.803e-03	-5.57	anion binding	molecular function	GO:0043168	2412	14	18094	49	ADCY2,ATP1A2,PRKG1,NTRK2,MAPK10,NAV2,PLCB1,DCLK2,CAMK2G,TNIK,PITPNC1,DGKG,ERBB4,PARD3
3.808e-03	-5.57	DELLA	smart domains	SM01129	1	1	9717	37	MACF1
3.829e-03	-5.57	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	16	16828	48	RYR3,CTNND2,FMN2,TNIK,PARD3,PRKG1,LRP1B,PITPNC1,MACF1,TRPM3,TNC,NKAIN3,SLC4A4,CLU,NRG3,ERBB4
3.829e-03	-5.57	gallbladder	COSMIC cancer mutations	gallbladder	2821	16	16828	48	PITPNC1,FMN2,TNIK,PARD3,PRKG1,LRP1B,RYR3,CTNND2,ERBB4,NRG3,TNC,NKAIN3,SLC4A4,CLU,MACF1,TRPM3
3.833e-03	-5.56	synaptic membrane	cellular component	GO:0097060	400	5	19108	50	ERBB4,SLC1A2,GPM6A,CNTN1,NRXN1
3.857e-03	-5.56	PTPRB (protein tyrosine phosphatase receptor type B)	protein interactions	5787	36	2	19454	50	CNTN1,TNC
3.897e-03	-5.55	regulation of transport	biological process	GO:0051049	1621	11	18204	50	CAMK2G,PRKG1,CLU,SORBS1,NKAIN3,GFAP,ATP1A2,CNTN1,PLCB1,SLC1A2,APOE
3.910e-03	-5.54	calcium channel activity	molecular function	GO:0005262	117	3	18094	49	TRPM3,GPM6A,RYR3
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	NTRK2,LSAMP,CNTN1,NTM
3.921e-03	-5.54	exploration behavior	biological process	GO:0035640	34	2	18204	50	ATP1A2,APOE
3.942e-03	-5.54	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	4	7161	29	ADCY2,ATP1A2,PLCB1,PRKG1
3.942e-03	-5.54	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	4	7161	29	PRKG1,ATP1A2,ADCY2,PLCB1
3.969e-03	-5.53	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	4	19454	50	ERBB4,TNIK,NTRK2,SORBS1
3.976e-03	-5.53	salivary_gland-submandibular-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-submandibular-carcinoma-adenoid_cystic_carcinoma	33	2	16828	48	LRP1B,NAV2
3.994e-03	-5.52	plasma lipoprotein particle	cellular component	GO:0034358	36	2	19108	50	APOE,CLU
3.994e-03	-5.52	lipoprotein particle	cellular component	GO:1990777	36	2	19108	50	APOE,CLU
4.068e-03	-5.50	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	4	16828	48	CTNND2,HPSE2,LRP1B,ERBB4
4.071e-03	-5.50	HPCA (hippocalcin)	protein interactions	3208	37	2	19454	50	CST3,GPM6A
4.071e-03	-5.50	PRRG4 (proline rich and Gla domain 4)	protein interactions	79056	37	2	19454	50	NEBL,ERBB4
4.071e-03	-5.50	MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2)	protein interactions	9863	37	2	19454	50	CTNND2,ERBB4
4.079e-03	-5.50	regulation of biological quality	biological process	GO:0065008	2936	16	18204	50	ERBB4,SLC4A4,DGKG,NTRK2,PLCB1,APOE,CAMK2G,GPM6A,MACF1,CTNNA2,PRKG1,NRXN1,CLU,NAV2,GFAP,ATP1A2
4.145e-03	-5.49	cellular process	biological process	GO:0009987	14996	48	18204	50	LRP1B,ERBB4,TNC,MGAT4C,TNIK,SLC1A2,RYR3,MSI2,CDH20,CLU,GFAP,NRXN1,ADCY2,CNTN1,NEBL,PLCB1,DTNA,CTNNA2,SLC14A1,DCLK2,CAMK2G,HPSE2,CST3,RORA,ATP1A2,NRG3,ABLIM1,GPC5,RFX4,APOE,DGKG,FMN2,TRPM3,SLC4A4,GLIS3,NTRK2,PITPNC1,NTM,LSAMP,MACF1,CTNND2,GPM6A,PRKG1,SOX5,PARD3,NAV2,SORBS1,MAPK10
4.157e-03	-5.48	organic substance transport	biological process	GO:0071702	1881	12	18204	50	LRP1B,SLC4A4,APOE,NTRK2,PITPNC1,SLC1A2,MACF1,SLC14A1,CAMK2G,FMN2,CLU,GFAP
4.196e-03	-5.47	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	3	16828	48	RYR3,SOX5,SLC1A2
4.215e-03	-5.47	glial cell projection	cellular component	GO:0097386	37	2	19108	50	GFAP,SLC1A2
4.267e-03	-5.46	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	3	7161	29	CAMK2G,ADCY2,PLCB1
4.267e-03	-5.46	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	3	7161	29	PLCB1,ADCY2,CAMK2G
4.290e-03	-5.45	RORA (RAR related orphan receptor A)	protein interactions	6095	38	2	19454	50	GFAP,RORA
4.290e-03	-5.45	MMP3 (matrix metallopeptidase 3)	protein interactions	4314	38	2	19454	50	APOE,CLU
4.354e-03	-5.44	Downregulation of ERBB2 signaling	REACTOME pathways	R-HSA-8863795	30	2	10285	34	NRG3,ERBB4
4.370e-03	-5.43	striated muscle contraction	biological process	GO:0006941	120	3	18204	50	RYR3,ATP1A2,DTNA
4.374e-03	-5.43	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	34	ATP1A2,CAMK2G,SORBS1,RYR3
4.376e-03	-5.43	PROTEIN_KINASE_ST	prosite domains	PS00108	308	5	12186	43	MAPK10,DCLK2,CAMK2G,PRKG1,TNIK
4.481e-03	-5.41	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	13	16828	48	ERBB4,DCLK2,NTRK2,SOX5,SLC4A4,ADCY2,ATP1A2,CAMK2G,DTNA,TNIK,GFAP,PRKG1,LRP1B
4.487e-03	-5.41	testis	COSMIC cancer mutations	testis	733	7	16828	48	PRKG1,NTRK2,TNIK,MACF1,CAMK2G,DCLK2,ERBB4
4.494e-03	-5.41	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	4	19454	50	MACF1,FMN2,PARD3,DTNA
4.530e-03	-5.40	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	8	16828	48	ATP1A2,ERBB4,DCLK2,CAMK2G,MACF1,NTRK2,TNIK,PRKG1
4.569e-03	-5.39	regulation of system process	biological process	GO:0044057	571	6	18204	50	PARD3,CAMK2G,NRXN1,PRKG1,APOE,ATP1A2
4.603e-03	-5.38	organic anion transport	biological process	GO:0015711	398	5	18204	50	APOE,GFAP,SLC4A4,SLC1A2,NTRK2
4.631e-03	-5.38	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	50	SORBS1,SLC1A2
4.674e-03	-5.37	protein-lipid complex	cellular component	GO:0032994	39	2	19108	50	CLU,APOE
4.718e-03	-5.36	submandibular	COSMIC cancer mutations	submandibular	36	2	16828	48	NAV2,LRP1B
4.723e-03	-5.36	transporter activity	molecular function	GO:0005215	1211	9	18094	49	PITPNC1,SLC14A1,ATP1A2,APOE,GPM6A,SLC1A2,TRPM3,SLC4A4,RYR3
4.744e-03	-5.35	SHC2 (SHC adaptor protein 2)	protein interactions	25759	40	2	19454	50	NTRK2,ERBB4
4.766e-03	-5.35	Ion channel transport	REACTOME pathways	R-HSA-983712	209	4	10285	34	RYR3,TRPM3,CAMK2G,ATP1A2
4.825e-03	-5.33	KIF20A (kinesin family member 20A)	protein interactions	10112	1044	8	19454	50	RORA,MSI2,PARD3,GFAP,NAV2,ABLIM1,MACF1,NEBL
4.880e-03	-5.32	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	50	GFAP,SLC1A2
4.907e-03	-5.32	EGF_3	prosite domains	PS50026	196	4	12186	43	LRP1B,NRG3,TNC,NRXN1
4.927e-03	-5.31	response to stimulus	biological process	GO:0050896	7803	31	18204	50	NRXN1,GFAP,CLU,FMN2,RYR3,SLC1A2,TNIK,DGKG,APOE,TNC,ERBB4,MAPK10,NRG3,ATP1A2,RORA,SORBS1,CST3,SOX5,PARD3,DCLK2,PRKG1,CTNNA2,CTNND2,GPM6A,MACF1,DTNA,PLCB1,PITPNC1,NTRK2,CNTN1,ADCY2
4.940e-03	-5.31	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	6	18094	49	TRPM3,SLC4A4,RYR3,ATP1A2,SLC1A2,GPM6A
4.944e-03	-5.31	calcium ion transport	biological process	GO:0006816	251	4	18204	50	RYR3,GPM6A,PLCB1,TRPM3
4.945e-03	-5.31	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	3	19454	50	GPM6A,CNTN1,NTM
4.980e-03	-5.30	RASSF7 (Ras association domain family member 7)	protein interactions	8045	41	2	19454	50	PARD3,CLU
4.995e-03	-5.30	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	6	16828	48	ERBB4,RYR3,CAMK2G,TNIK,NTRK2,LRP1B
5.021e-03	-5.29	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	15	16828	48	HPSE2,TRPM3,CNTN1,TNC,NTRK2,SOX5,SLC1A2,NRG3,RFX4,DGKG,CTNND2,LRP1B,FMN2,ADCY2,ATP1A2
5.038e-03	-5.29	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	11	16828	48	DGKG,CNTN1,RORA,ABLIM1,MACF1,CDH20,PLCB1,FMN2,SORBS1,CTNND2,DTNA
5.038e-03	-5.29	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	11	16828	48	DTNA,CTNND2,PLCB1,FMN2,SORBS1,CDH20,MACF1,ABLIM1,RORA,CNTN1,DGKG
5.099e-03	-5.28	collagen-containing extracellular matrix	cellular component	GO:0062023	428	5	19108	50	CLU,TNC,APOE,GPC5,NAV2
5.127e-03	-5.27	RHOB (ras homolog family member B)	protein interactions	388	832	7	19454	50	PARD3,PLCB1,DTNA,ABLIM1,MACF1,TNIK,FMN2
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	URA1 (dihydroorotate dehydrogenase)	protein interactions	853664	2	1	19454	50	GFAP
5.134e-03	-5.27	EST1 (Est1p)	protein interactions	850934	2	1	19454	50	NAV2
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	TRIM39-RPP21 (TRIM39-RPP21 readthrough)	protein interactions	202658	2	1	19454	50	PRKG1
5.134e-03	-5.27	cdh11.S (cadherin 11 S homeolog)	protein interactions	100337621	2	1	19454	50	ERBB4
5.134e-03	-5.27	positive regulation of nitric oxide biosynthetic process	biological process	GO:0045429	39	2	18204	50	APOE,CLU
5.134e-03	-5.27	olfactory lobe development	biological process	GO:0021988	39	2	18204	50	ATP1A2,ERBB4
5.134e-03	-5.27	cellular response to alkaloid	biological process	GO:0071312	39	2	18204	50	RYR3,SLC1A2
5.198e-03	-5.26	RDX (radixin)	protein interactions	5962	272	4	19454	50	MACF1,NEBL,MAPK10,ABLIM1
5.202e-03	-5.26	Gap junction	KEGG pathways	hsa04540	88	3	7161	29	PRKG1,PLCB1,ADCY2
5.202e-03	-5.26	Gap junction	KEGG pathways	ko04540	88	3	7161	29	PRKG1,PLCB1,ADCY2
5.227e-03	-5.25	chylomicron remnant	cellular component	GO:0034360	2	1	19108	50	APOE
5.227e-03	-5.25	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	50	APOE
5.230e-03	-5.25	Laminin	gene3d domains	2.10.25.10	226	4	14470	45	TNC,NRG3,LRP1B,NRXN1
5.265e-03	-5.25	FLOT2 (flotillin 2)	protein interactions	2319	273	4	19454	50	PARD3,SOX5,SLC14A1,NTRK2
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	cGMP_dep_kinase	interpro domains	IPR002374	2	1	18521	50	PRKG1
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.392e-03	-5.22	STKc_cGK	interpro domains	IPR035014	2	1	18521	50	PRKG1
5.392e-03	-5.22	Par3/HAL_N	interpro domains	IPR021922	2	1	18521	50	PARD3
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	LRP1-like_beta_prop	interpro domains	IPR032485	2	1	18521	50	LRP1B
5.392e-03	-5.22	Urea_transporter	interpro domains	IPR004937	2	1	18521	50	SLC14A1
5.392e-03	-5.22	PLC-beta_CS	interpro domains	IPR009535	2	1	18521	50	PLCB1
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Glyco_hydro_79	interpro domains	IPR005199	2	1	18521	50	HPSE2
5.392e-03	-5.22	Contactin-1_2_Ig1	interpro domains	IPR047102	2	1	18521	50	CNTN1
5.395e-03	-5.22	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	2	18204	50	ADCY2,RORA
5.395e-03	-5.22	positive regulation of nitric oxide metabolic process	biological process	GO:1904407	40	2	18204	50	CLU,APOE
5.402e-03	-5.22	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	11	16828	48	GPC5,NPAS3,PRKG1,LRP1B,PARD3,NEBL,MACF1,TRPM3,SOX5,DCLK2,ERBB4
5.409e-03	-5.22	heparanase activity	molecular function	GO:0030305	2	1	18094	49	HPSE2
5.409e-03	-5.22	cGMP-dependent protein kinase activity	molecular function	GO:0004692	2	1	18094	49	PRKG1
5.410e-03	-5.22	Neuronal System	REACTOME pathways	R-HSA-112316	349	5	10285	34	PLCB1,ADCY2,SLC1A2,CAMK2G,NRXN1
5.443e-03	-5.21	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	4	10285	34	ADCY2,PLCB1,CAMK2G,SLC1A2
5.466e-03	-5.21	C2CD4B (C2 calcium dependent domain containing 4B)	protein interactions	388125	43	2	19454	50	MACF1,LRP1B
5.467e-03	-5.21	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	4	16828	48	NAV2,MGAT4C,GLIS3,MACF1
5.475e-03	-5.21	NEFM (neurofilament medium chain)	protein interactions	4741	139	3	19454	50	TNIK,GFAP,APOE
5.486e-03	-5.21	negative regulation of monocyte extravasation	biological process	GO:2000438	2	1	18204	50	PLCB1
5.486e-03	-5.21	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	50	CST3
5.486e-03	-5.21	mesenchymal-epithelial cell signaling involved in prostate gland development	biological process	GO:0060739	2	1	18204	50	TNC
5.486e-03	-5.21	establishment of planar polarity involved in nephron morphogenesis	biological process	GO:0072046	2	1	18204	50	ERBB4
5.486e-03	-5.21	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	50	CLU
5.486e-03	-5.21	cellular response to fluoride	biological process	GO:1902618	2	1	18204	50	PLCB1
5.486e-03	-5.21	negative regulation of inositol phosphate biosynthetic process	biological process	GO:0010920	2	1	18204	50	PRKG1
5.486e-03	-5.21	phosphatidylinositol catabolic process	biological process	GO:0031161	2	1	18204	50	PLCB1
5.486e-03	-5.21	activation of meiosis involved in egg activation	biological process	GO:0060466	2	1	18204	50	PLCB1
5.486e-03	-5.21	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	50	APOE
5.486e-03	-5.21	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	50	CST3
5.500e-03	-5.20	Clusterin	pfam domains	PF01093	2	1	17795	49	CLU
5.500e-03	-5.20	DUF5050	pfam domains	PF16472	2	1	17795	49	LRP1B
5.500e-03	-5.20	Glyco_hydro_79n	pfam domains	PF03662	2	1	17795	49	HPSE2
5.500e-03	-5.20	Par3_HAL_N_term	pfam domains	PF12053	2	1	17795	49	PARD3
5.500e-03	-5.20	DUF1154	pfam domains	PF06631	2	1	17795	49	PLCB1
5.500e-03	-5.20	UT	pfam domains	PF03253	2	1	17795	49	SLC14A1
5.614e-03	-5.18	embryonal	COSMIC cancer mutations	embryonal	2659	15	16828	48	NPAS3,CTNND2,CAMK2G,RYR3,LRP1B,SORBS1,FMN2,ADCY2,TRPM3,MACF1,RORA,TNC,APOE,GLIS3,NAV2
5.614e-03	-5.18	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	15	16828	48	LRP1B,SORBS1,FMN2,CTNND2,NPAS3,RYR3,CAMK2G,ADCY2,RORA,TNC,APOE,MACF1,TRPM3,NAV2,GLIS3
5.653e-03	-5.18	protein localization	biological process	GO:0008104	1954	12	18204	50	PARD3,FMN2,DCLK2,CAMK2G,MACF1,NRXN1,GFAP,CLU,ERBB4,LRP1B,TNIK,APOE
5.658e-03	-5.17	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	2	19108	50	CAMK2G,RYR3
5.662e-03	-5.17	cyclic nucleotide metabolic process	biological process	GO:0009187	41	2	18204	50	ADCY2,RORA
5.664e-03	-5.17	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	39	16828	48	NEBL,ADCY2,CDH20,PARD3,PRKG1,DTNA,CAMK2G,CTNND2,GPC5,NPAS3,RFX4,NRG3,SOX5,CLU,LSAMP,ABLIM1,RORA,MACF1,HPSE2,TRPM3,MGAT4C,ATP1A2,PLCB1,SORBS1,GPM6A,TNIK,FMN2,GFAP,LRP1B,RYR3,ERBB4,NAV2,DGKG,TNC,NKAIN3,NTRK2,SLC1A2,CNTN1,NRXN1
5.697e-03	-5.17	amino acid transport	biological process	GO:0006865	132	3	18204	50	GFAP,NTRK2,SLC1A2
5.765e-03	-5.16	parotid	COSMIC cancer mutations	parotid	578	6	16828	48	TNIK,NTRK2,LRP1B,CAMK2G,RYR3,ERBB4
5.817e-03	-5.15	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	50	ATP1A2,RYR3,PLCB1
5.840e-03	-5.14	cellular macromolecule localization	biological process	GO:0070727	1962	12	18204	50	PARD3,FMN2,DCLK2,ERBB4,CAMK2G,LRP1B,MACF1,TNIK,NRXN1,GFAP,APOE,CLU
5.867e-03	-5.14	protein serine/threonine kinase activity	molecular function	GO:0004674	428	5	18094	49	TNIK,MAPK10,CAMK2G,DCLK2,PRKG1
5.935e-03	-5.13	regulation of amino acid transport	biological process	GO:0051955	42	2	18204	50	ATP1A2,PRKG1
5.935e-03	-5.13	Schwann cell development	biological process	GO:0014044	42	2	18204	50	PARD3,NTRK2
5.935e-03	-5.13	triglyceride homeostasis	biological process	GO:0070328	42	2	18204	50	APOE,RORA
5.939e-03	-5.13	regulation of growth	biological process	GO:0040008	603	6	18204	50	MACF1,ERBB4,TNC,APOE,NRG3,PLCB1
5.946e-03	-5.13	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	49	TRPM3,RYR3,GPM6A
5.946e-03	-5.12	spleen	COSMIC cancer mutations	spleen	408	5	16828	48	TNIK,SORBS1,NTM,LRP1B,ADCY2
5.997e-03	-5.12	prostate	COSMIC cancer mutations	prostate	13883	46	16828	48	NEBL,NTM,PRKG1,DTNA,GPC5,RFX4,NRG3,RORA,LSAMP,CLU,MACF1,HPSE2,ATP1A2,PITPNC1,TNIK,PLCB1,LRP1B,ERBB4,NAV2,GLIS3,SLC1A2,NKAIN3,APOE,TNC,NRXN1,ADCY2,CDH20,PARD3,NPAS3,CTNND2,DCLK2,SLC14A1,SLC4A4,SOX5,ABLIM1,TRPM3,MGAT4C,GFAP,FMN2,GPM6A,SORBS1,RYR3,DGKG,NTRK2,CNTN1,MSI2
6.037e-03	-5.11	Calml3 (calmodulin-like 3)	protein interactions	70405	144	3	19454	50	MACF1,ABLIM1,CAMK2G
6.044e-03	-5.11	tau protein binding	molecular function	GO:0048156	43	2	18094	49	CLU,APOE
6.087e-03	-5.10	femur	COSMIC cancer mutations	femur	1197	9	16828	48	FMN2,SLC4A4,LRP1B,RYR3,HPSE2,GPC5,NAV2,ADCY2,NRG3
6.090e-03	-5.10	monoatomic ion transmembrane transport	biological process	GO:0034220	804	7	18204	50	TRPM3,SLC4A4,RYR3,GPM6A,PLCB1,SLC1A2,ATP1A2
6.210e-03	-5.08	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	45	CTNNA2
6.210e-03	-5.08	-	gene3d domains	6.20.350.10	2	1	14470	45	RYR3
6.213e-03	-5.08	acylglycerol homeostasis	biological process	GO:0055090	43	2	18204	50	RORA,APOE
6.234e-03	-5.08	EXTL2 (exostosin like glycosyltransferase 2)	protein interactions	2135	46	2	19454	50	CLU,MGAT4C
6.237e-03	-5.08	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	5	18204	50	SORBS1,NRG3,PLCB1,ERBB4,NTRK2
6.391e-03	-5.05	MOB4 (MOB family member 4, phocein)	protein interactions	25843	147	3	19454	50	TNIK,ABLIM1,CAMK2G
6.420e-03	-5.05	trans-synaptic signaling	biological process	GO:0099537	431	5	18204	50	APOE,NTRK2,NRXN1,SLC1A2,DTNA
6.498e-03	-5.04	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	50	SORBS1,SLC1A2
6.512e-03	-5.03	LRP2 (LDL receptor related protein 2)	protein interactions	4036	148	3	19454	50	CLU,APOE,LRP1B
6.590e-03	-5.02	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	20	16828	48	NRXN1,MACF1,TRPM3,SOX5,LSAMP,GLIS3,NAV2,ERBB4,DGKG,RYR3,DTNA,GPC5,CTNND2,PLCB1,TNIK,PARD3,PRKG1,LRP1B,ADCY2,ATP1A2
6.640e-03	-5.01	bone-femur-chondrosarcoma	COSMIC cancer mutations	bone-femur-chondrosarcoma	419	5	16828	48	LRP1B,NAV2,SLC4A4,HPSE2,ADCY2
6.676e-03	-5.01	inorganic cation transmembrane transport	biological process	GO:0098662	618	6	18204	50	RYR3,GPM6A,ATP1A2,TRPM3,PLCB1,SLC4A4
6.702e-03	-5.01	neurotransmitter transport	biological process	GO:0006836	140	3	18204	50	SLC1A2,NRXN1,ATP1A2
6.772e-03	-4.99	HTRA1 (HtrA serine peptidase 1)	protein interactions	5654	48	2	19454	50	MGAT4C,APOE
6.788e-03	-4.99	acidic amino acid transport	biological process	GO:0015800	45	2	18204	50	SLC1A2,NTRK2
6.788e-03	-4.99	negative regulation of blood coagulation	biological process	GO:0030195	45	2	18204	50	APOE,PRKG1
6.817e-03	-4.99	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	6	18094	49	TRPM3,SLC4A4,RYR3,ATP1A2,GPM6A,SLC1A2
6.875e-03	-4.98	transmembrane transport	biological process	GO:0055085	1264	9	18204	50	GFAP,ATP1A2,PLCB1,SLC1A2,SLC14A1,RYR3,GPM6A,SLC4A4,TRPM3
6.875e-03	-4.98	Ig_3	pfam domains	PF13927	141	3	17795	49	CNTN1,NTM,LSAMP
6.876e-03	-4.98	FORMIN	prints domains	PR00828	2	1	5227	18	FMN2
6.876e-03	-4.98	CGMPKINASE	prints domains	PR00104	2	1	5227	18	PRKG1
6.919e-03	-4.97	membrane raft	cellular component	GO:0045121	290	4	19108	50	ADCY2,SORBS1,ATP1A2,SLC1A2
6.969e-03	-4.97	neuron migration	biological process	GO:0001764	142	3	18204	50	PRKG1,GPM6A,NTRK2
6.969e-03	-4.97	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	50	APOE,SORBS1,SLC4A4
7.044e-03	-4.96	protein binding	molecular function	GO:0005515	13983	45	18094	49	NPAS3,SOX5,HPSE2,PARD3,GPC5,MSI2,ATP1A2,SLC1A2,CDH20,ABLIM1,SORBS1,PLCB1,NTRK2,CTNND2,CLU,LSAMP,CNTN1,GLIS3,CST3,GFAP,NRG3,RFX4,TNIK,CAMK2G,MACF1,SLC4A4,DTNA,TNC,NAV2,CTNNA2,PITPNC1,FMN2,NRXN1,NTM,LRP1B,ERBB4,RYR3,PRKG1,APOE,GPM6A,ADCY2,RORA,DCLK2,MAPK10,NEBL
7.059e-03	-4.95	nitrogen compound transport	biological process	GO:0071705	1507	10	18204	50	SLC1A2,NTRK2,GFAP,APOE,CLU,FMN2,CAMK2G,SLC14A1,LRP1B,MACF1
7.084e-03	-4.95	negative regulation of hemostasis	biological process	GO:1900047	46	2	18204	50	APOE,PRKG1
7.084e-03	-4.95	receptor clustering	biological process	GO:0043113	46	2	18204	50	NRXN1,APOE
7.086e-03	-4.95	membrane microdomain	cellular component	GO:0098857	292	4	19108	50	ADCY2,SORBS1,ATP1A2,SLC1A2
7.110e-03	-4.95	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	13	16828	48	DCLK2,ERBB4,SOX5,SLC4A4,NTRK2,ATP1A2,ADCY2,LRP1B,PRKG1,GFAP,TNIK,DTNA,CAMK2G
7.295e-03	-4.92	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	48	MACF1,MGAT4C
7.295e-03	-4.92	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	48	MGAT4C,MACF1
7.312e-03	-4.92	metal ion transport	biological process	GO:0030001	630	6	18204	50	ATP1A2,RYR3,GPM6A,PLCB1,SLC4A4,TRPM3
7.366e-03	-4.91	ion binding	molecular function	GO:0043167	6007	25	18094	49	ADCY2,RORA,APOE,GLIS3,PRKG1,MAPK10,DCLK2,PITPNC1,DGKG,RYR3,ERBB4,LRP1B,MGAT4C,NRXN1,SLC1A2,ATP1A2,NTRK2,NAV2,PLCB1,DTNA,ABLIM1,CAMK2G,TNIK,MACF1,PARD3
7.386e-03	-4.91	regulation of neuron migration	biological process	GO:2001222	47	2	18204	50	CTNNA2,NRG3
7.386e-03	-4.91	Schwann cell differentiation	biological process	GO:0014037	47	2	18204	50	PARD3,NTRK2
7.521e-03	-4.89	adult behavior	biological process	GO:0030534	146	3	18204	50	NRXN1,SLC1A2,ATP1A2
7.525e-03	-4.89	CEP19 (centrosomal protein 19)	protein interactions	84984	156	3	19454	50	FMN2,PARD3,ABLIM1
7.542e-03	-4.89	intracellular signaling cassette	biological process	GO:0141124	837	7	18204	50	ADCY2,RYR3,PRKG1,TNIK,MAPK10,ATP1A2,APOE
7.601e-03	-4.88	CLa	smart domains	SM00035	2	1	9717	37	CLU
7.601e-03	-4.88	CLb	smart domains	SM00030	2	1	9717	37	CLU
7.617e-03	-4.88	FAM171B (family with sequence similarity 171 member B)	protein interactions	165215	51	2	19454	50	PARD3,NTRK2
7.626e-03	-4.88	Melanogenesis	KEGG pathways	hsa04916	101	3	7161	29	PLCB1,ADCY2,CAMK2G
7.626e-03	-4.88	Melanogenesis	KEGG pathways	ko04916	101	3	7161	29	CAMK2G,ADCY2,PLCB1
7.626e-03	-4.88	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	3	7161	29	MAPK10,PLCB1,ADCY2
7.626e-03	-4.88	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	3	7161	29	MAPK10,PLCB1,ADCY2
7.646e-03	-4.87	monoatomic cation transmembrane transport	biological process	GO:0098655	636	6	18204	50	SLC4A4,PLCB1,TRPM3,ATP1A2,GPM6A,RYR3
7.691e-03	-4.87	TULP1 (TUB like protein 1)	protein interactions	7287	3	1	19454	50	NRXN1
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.691e-03	-4.87	NRG3 (neuregulin 3)	protein interactions	10718	3	1	19454	50	ERBB4
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Itgb1 (integrin subunit beta 1)	protein interactions	24511	3	1	19454	50	TNC
7.691e-03	-4.87	Lrrc7 (leucine rich repeat containing 7)	protein interactions	117284	3	1	19454	50	CAMK2G
7.749e-03	-4.86	purine ribonucleoside triphosphate binding	molecular function	GO:0035639	1804	11	18094	49	ATP1A2,PRKG1,ADCY2,CAMK2G,TNIK,ERBB4,DCLK2,NTRK2,DGKG,MAPK10,NAV2
7.790e-03	-4.85	calcium channel regulator activity	molecular function	GO:0005246	49	2	18094	49	PRKG1,NRXN1
7.832e-03	-4.85	response to organic cyclic compound	biological process	GO:0014070	843	7	18204	50	TNC,RYR3,ADCY2,PLCB1,SLC1A2,RORA,ATP1A2
7.834e-03	-4.85	cAMP signaling pathway	KEGG pathways	hsa04024	198	4	7161	29	ADCY2,ATP1A2,CAMK2G,MAPK10
7.834e-03	-4.85	cAMP signaling pathway	KEGG pathways	ko04024	198	4	7161	29	ATP1A2,ADCY2,MAPK10,CAMK2G
7.836e-03	-4.85	Glucagon signaling pathway	KEGG pathways	hsa04922	102	3	7161	29	ADCY2,PLCB1,CAMK2G
7.836e-03	-4.85	Glucagon signaling pathway	KEGG pathways	ko04922	102	3	7161	29	CAMK2G,PLCB1,ADCY2
7.847e-03	-4.85	regulation of cell migration	biological process	GO:0030334	1061	8	18204	50	PLCB1,NRG3,APOE,TNC,ERBB4,CTNNA2,PRKG1,MACF1
7.909e-03	-4.84	SNAP91 (synaptosome associated protein 91)	protein interactions	9892	52	2	19454	50	ERBB4,GPM6A
8.007e-03	-4.83	negative regulation of coagulation	biological process	GO:0050819	49	2	18204	50	APOE,PRKG1
8.007e-03	-4.83	oligodendrocyte development	biological process	GO:0014003	49	2	18204	50	CNTN1,CLU
8.012e-03	-4.83	skin-subungual-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-subungual-malignant_melanoma-acral_lentiginous	144	3	16828	48	CDH20,MACF1,LRP1B
8.021e-03	-4.83	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	8	19454	50	PITPNC1,APOE,SORBS1,PARD3,CAMK2G,ABLIM1,NAV2,MACF1
8.045e-03	-4.82	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	5	16828	48	CAMK2G,TNIK,NTRK2,ERBB4,PRKG1
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	TM_ErbB1	interpro domains	IPR049328	3	1	18521	50	ERBB4
8.078e-03	-4.82	DGK_typeI_N_sf	interpro domains	IPR038199	3	1	18521	50	DGKG
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	Nav/unc-53	interpro domains	IPR039041	3	1	18521	50	NAV2
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	DAG_kinase_typeI_N	interpro domains	IPR029477	3	1	18521	50	DGKG
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	MAPK_JNK	interpro domains	IPR008351	3	1	18521	50	MAPK10
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	PLC-beta_C	interpro domains	IPR014815	3	1	18521	50	PLCB1
8.091e-03	-4.82	lipid binding	molecular function	GO:0008289	861	7	18094	49	PITPNC1,ATP1A2,APOE,RORA,PARD3,PLCB1,DGKG
8.097e-03	-4.82	regulation of nervous system development	biological process	GO:0051960	456	5	18204	50	MACF1,GFAP,NTRK2,NRXN1,PARD3
8.103e-03	-4.82	JUN kinase activity	molecular function	GO:0004705	3	1	18094	49	MAPK10
8.103e-03	-4.82	epidermal growth factor receptor activity	molecular function	GO:0005006	3	1	18094	49	ERBB4
8.103e-03	-4.82	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	49	SLC1A2
8.103e-03	-4.82	urea channel activity	molecular function	GO:0015265	3	1	18094	49	SLC14A1
8.103e-03	-4.82	neuregulin receptor activity	molecular function	GO:0038131	3	1	18094	49	ERBB4
8.103e-03	-4.82	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular function	GO:0008454	3	1	18094	49	MGAT4C
8.206e-03	-4.80	GOLGA6A (golgin A6 family member A)	protein interactions	342096	53	2	19454	50	NEBL,GFAP
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.218e-03	-4.80	central nervous system morphogenesis	biological process	GO:0021551	3	1	18204	50	ERBB4
8.218e-03	-4.80	cellular response to ionomycin	biological process	GO:1904637	3	1	18204	50	PLCB1
8.218e-03	-4.80	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	50	CTNNA2
8.218e-03	-4.80	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	50	NTRK2
8.218e-03	-4.80	Schwann cell proliferation	biological process	GO:0014010	3	1	18204	50	GFAP
8.218e-03	-4.80	positive regulation of Schwann cell proliferation	biological process	GO:0010625	3	1	18204	50	GFAP
8.218e-03	-4.80	mammary placode formation	biological process	GO:0060596	3	1	18204	50	NRG3
8.218e-03	-4.80	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	50	APOE
8.218e-03	-4.80	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	50	FMN2
8.218e-03	-4.80	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	50	FMN2
8.218e-03	-4.80	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	50	CLU
8.218e-03	-4.80	vagus nerve development	biological process	GO:0021564	3	1	18204	50	NAV2
8.218e-03	-4.80	neuroligin clustering involved in postsynaptic membrane assembly	biological process	GO:0097118	3	1	18204	50	NRXN1
8.218e-03	-4.80	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	50	APOE
8.218e-03	-4.80	response to ionomycin	biological process	GO:1904636	3	1	18204	50	PLCB1
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.218e-03	-4.80	regulation of retrograde trans-synaptic signaling by endocanabinoid	biological process	GO:0099178	3	1	18204	50	PLCB1
8.218e-03	-4.80	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	50	FMN2
8.218e-03	-4.80	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	50	NEBL
8.218e-03	-4.80	immune complex clearance	biological process	GO:0002434	3	1	18204	50	CLU
8.218e-03	-4.80	bud outgrowth involved in lung branching	biological process	GO:0060447	3	1	18204	50	TNC
8.220e-03	-4.80	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	4	16828	48	LRP1B,ERBB4,ATP1A2,TNIK
8.238e-03	-4.80	SR_plectin_7	pfam domains	PF21097	3	1	17795	49	MACF1
8.238e-03	-4.80	Myelin_PLP	pfam domains	PF01275	3	1	17795	49	GPM6A
8.238e-03	-4.80	DAG_kinase_N	pfam domains	PF14513	3	1	17795	49	DGKG
8.238e-03	-4.80	TM_ErbB1	pfam domains	PF21314	3	1	17795	49	ERBB4
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR3
8.238e-03	-4.80	Sorb	pfam domains	PF02208	3	1	17795	49	SORBS1
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR3
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR3
8.238e-03	-4.80	PLC-beta_C	pfam domains	PF08703	3	1	17795	49	PLCB1
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK2
8.266e-03	-4.80	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	48	2	16828	48	PARD3,RYR3
8.288e-03	-4.79	ear	COSMIC cancer mutations	ear	624	6	16828	48	SLC14A1,NPAS3,TNC,MGAT4C,PRKG1,LRP1B
8.317e-03	-4.79	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	5	10285	34	ERBB4,NTRK2,NRG3,ADCY2,CAMK2G
8.327e-03	-4.79	vasodilation	biological process	GO:0042311	50	2	18204	50	APOE,PRKG1
8.343e-03	-4.79	CCDC57 (coiled-coil domain containing 57)	protein interactions	284001	162	3	19454	50	DCLK2,GFAP,ABLIM1
8.343e-03	-4.79	DSCAM (DS cell adhesion molecule)	protein interactions	1826	162	3	19454	50	GFAP,MACF1,CLU
8.397e-03	-4.78	regulation of tube diameter	biological process	GO:0035296	152	3	18204	50	PRKG1,ATP1A2,APOE
8.397e-03	-4.78	blood vessel diameter maintenance	biological process	GO:0097746	152	3	18204	50	ATP1A2,APOE,PRKG1
8.411e-03	-4.78	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	35	16828	48	CNTN1,APOE,TNC,NKAIN3,NTRK2,MSI2,NAV2,DGKG,ERBB4,GLIS3,LRP1B,SORBS1,FMN2,PLCB1,TNIK,RYR3,PITPNC1,MGAT4C,ATP1A2,CLU,LSAMP,RORA,SOX5,SLC4A4,MACF1,HPSE2,TRPM3,DCLK2,PRKG1,CTNND2,GPC5,CAMK2G,NEBL,CDH20,ADCY2
8.476e-03	-4.77	subungual	COSMIC cancer mutations	subungual	147	3	16828	48	CDH20,MACF1,LRP1B
8.549e-03	-4.76	regulation of tube size	biological process	GO:0035150	153	3	18204	50	APOE,ATP1A2,PRKG1
8.604e-03	-4.76	cellular response to stimulus	biological process	GO:0051716	6307	26	18204	50	PITPNC1,NTRK2,DTNA,PLCB1,ADCY2,CNTN1,SORBS1,RORA,ATP1A2,MAPK10,NRG3,CTNND2,MACF1,PRKG1,DCLK2,PARD3,APOE,DGKG,TNIK,SLC1A2,ERBB4,TNC,CLU,GFAP,RYR3,FMN2
8.667e-03	-4.75	anchoring junction	cellular component	GO:0070161	902	7	19108	50	TNC,ATP1A2,CTNND2,SORBS1,PARD3,CTNNA2,CDH20
8.748e-03	-4.74	ZYX (zyxin)	protein interactions	7791	316	4	19454	50	SORBS1,NEBL,MACF1,ABLIM1
8.771e-03	-4.74	positive regulation of nervous system development	biological process	GO:0051962	296	4	18204	50	GFAP,MACF1,NTRK2,NRXN1
8.814e-03	-4.73	SYN1 (synapsin I)	protein interactions	6853	55	2	19454	50	GPM6A,CAMK2G
8.814e-03	-4.73	PLCB1 (phospholipase C beta 1)	protein interactions	23236	55	2	19454	50	PLCB1,PARD3
8.841e-03	-4.73	neuronal cell body	cellular component	GO:0043025	489	5	19108	50	APOE,GPM6A,ATP1A2,NRXN1,CTNND2
8.857e-03	-4.73	regeneration	biological process	GO:0031099	155	3	18204	50	GFAP,ERBB4,TNC
8.869e-03	-4.73	mannosyl-glycoprotein N-acetylglucosaminyltransferases	BIOCYC pathways	META_PWY-7426	8	1	902	1	MGAT4C
8.873e-03	-4.72	muscle system process	biological process	GO:0003012	297	4	18204	50	DTNA,PRKG1,ATP1A2,RYR3
8.873e-03	-4.72	carboxylic acid transport	biological process	GO:0046942	297	4	18204	50	APOE,GFAP,NTRK2,SLC1A2
8.903e-03	-4.72	endoplasmic reticulum lumen	cellular component	GO:0005788	312	4	19108	50	CST3,CLU,APOE,TNC
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	NEBL,ABLIM1,ATP1A2
8.972e-03	-4.71	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	3	18094	49	SLC1A2,ATP1A2,SLC4A4
8.976e-03	-4.71	organic acid transport	biological process	GO:0015849	298	4	18204	50	GFAP,APOE,SLC1A2,NTRK2
8.985e-03	-4.71	positive regulation of biological process	biological process	GO:0048518	6326	26	18204	50	PARD3,HPSE2,SOX5,GPM6A,MACF1,PRKG1,SORBS1,RORA,ATP1A2,CNTN1,SLC4A4,GLIS3,NTRK2,NPAS3,PLCB1,FMN2,NRXN1,CLU,GFAP,ERBB4,GPC5,TNC,TNIK,SLC1A2,APOE,RFX4
9.013e-03	-4.71	protein autophosphorylation	biological process	GO:0046777	156	3	18204	50	NTRK2,TNIK,ERBB4
9.125e-03	-4.70	SEPTIN3 (septin 3)	protein interactions	55964	56	2	19454	50	PRKG1,GPM6A
9.125e-03	-4.70	L1CAM (L1 cell adhesion molecule)	protein interactions	3897	56	2	19454	50	GPM6A,CNTN1
9.125e-03	-4.70	CSTL1 (cystatin like 1)	protein interactions	128817	56	2	19454	50	APOE,CLU
9.171e-03	-4.69	positive regulation of synaptic transmission	biological process	GO:0050806	157	3	18204	50	NTRK2,NRXN1,GFAP
9.200e-03	-4.69	Retinoid metabolism and transport	REACTOME pathways	R-HSA-975634	44	2	10285	34	GPC5,APOE
9.272e-03	-4.68	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	4	16828	48	SLC1A2,GFAP,PRKG1,NRG3
9.272e-03	-4.68	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	4	16828	48	SLC1A2,GFAP,PRKG1,NRG3
9.301e-03	-4.68	Diacylglycerol kinase alpha	gene3d domains	1.10.238.110	3	1	14470	45	DGKG
9.301e-03	-4.68	-	gene3d domains	6.10.250.2510	3	1	14470	45	CTNNA2
9.301e-03	-4.68	-	gene3d domains	1.10.490.160	3	1	14470	45	RYR3
9.318e-03	-4.68	regulation of platelet activation	biological process	GO:0010543	53	2	18204	50	PRKG1,APOE
9.361e-03	-4.67	PIAS2 (protein inhibitor of activated STAT 2)	protein interactions	9063	169	3	19454	50	GFAP,SOX5,NAV2
9.399e-03	-4.67	positive regulation of MAPK cascade	biological process	GO:0043410	473	5	18204	50	NTRK2,TNIK,ERBB4,PLCB1,APOE
9.401e-03	-4.67	postsynaptic density	cellular component	GO:0014069	317	4	19108	50	CTNND2,TNIK,ERBB4,NTRK2
9.442e-03	-4.66	NXPH3 (neurexophilin 3)	protein interactions	11248	57	2	19454	50	NRXN1,CTNNA2
9.608e-03	-4.65	Non-integrin membrane-ECM interactions	REACTOME pathways	R-HSA-3000171	45	2	10285	34	NRXN1,TNC
9.659e-03	-4.64	regulation of alcohol biosynthetic process	biological process	GO:1902930	54	2	18204	50	APOE,PRKG1
9.724e-03	-4.63	S_TKc	smart domains	SM00220	348	5	9717	37	DCLK2,MAPK10,PRKG1,CAMK2G,TNIK
9.763e-03	-4.63	CILK1 (ciliogenesis associated kinase 1)	protein interactions	22858	58	2	19454	50	MSI2,CAMK2G
9.770e-03	-4.63	regulation of response to stimulus	biological process	GO:0048583	4104	19	18204	50	APOE,DGKG,NTRK2,TNIK,PLCB1,ERBB4,GPC5,TNC,SORBS1,CLU,RORA,NRXN1,MAPK10,CTNND2,MACF1,PRKG1,CTNNA2,CAMK2G,FMN2
9.819e-03	-4.62	positive regulation of neuron projection development	biological process	GO:0010976	161	3	18204	50	CNTN1,NTRK2,APOE
9.819e-03	-4.62	negative regulation of supramolecular fiber organization	biological process	GO:1902904	161	3	18204	50	CLU,APOE,CTNNA2
9.833e-03	-4.62	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	4	19454	50	DTNA,TNIK,SORBS1,PARD3
9.883e-03	-4.62	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	6	16828	48	ERBB4,DCLK2,TNIK,NTRK2,PRKG1,CAMK2G
9.954e-03	-4.61	calcium ion binding	molecular function	GO:0005509	683	6	18094	49	DGKG,RYR3,MACF1,LRP1B,PLCB1,NRXN1
1.001e-02	-4.60	intermembrane lipid transfer	biological process	GO:0120009	55	2	18204	50	PITPNC1,APOE
1.008e-02	-4.60	lipid transfer activity	molecular function	GO:0120013	56	2	18094	49	PITPNC1,APOE
1.009e-02	-4.60	ADAM17 (ADAM metallopeptidase domain 17)	protein interactions	6868	59	2	19454	50	CAMK2G,ERBB4
1.010e-02	-4.59	purine ribonucleotide binding	molecular function	GO:0032555	1871	11	18094	49	TNIK,CAMK2G,ADCY2,PRKG1,ATP1A2,NAV2,MAPK10,DGKG,NTRK2,DCLK2,ERBB4
1.012e-02	-4.59	Cholinergic synapse	KEGG pathways	hsa04725	112	3	7161	29	CAMK2G,ADCY2,PLCB1
1.019e-02	-4.59	macromolecule localization	biological process	GO:0033036	2376	13	18204	50	PITPNC1,TNIK,APOE,ERBB4,LRP1B,NRXN1,GFAP,CLU,FMN2,PARD3,CAMK2G,DCLK2,MACF1
1.024e-02	-4.58	CALML4 (calmodulin like 4)	protein interactions	91860	4	1	19454	50	CAMK2G
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	IGKV@ (immunoglobulin kappa variable cluster)	protein interactions	3519	4	1	19454	50	LRP1B
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.029e-02	-4.58	LRP1 (LDL receptor related protein 1)	protein interactions	4035	175	3	19454	50	CLU,APOE,LRP1B
1.030e-02	-4.58	RYANODINER	prints domains	PR00795	3	1	5227	18	RYR3
1.030e-02	-4.58	NTKRECEPTOR	prints domains	PR01939	3	1	5227	18	NTRK2
1.030e-02	-4.58	RORNUCRECPTR	prints domains	PR01293	3	1	5227	18	RORA
1.030e-02	-4.58	MYELINPLP	prints domains	PR00214	3	1	5227	18	GPM6A
1.030e-02	-4.58	JNKMAPKINASE	prints domains	PR01772	3	1	5227	18	MAPK10
1.031e-02	-4.58	dendritic spine	cellular component	GO:0043197	172	3	19108	50	ATP1A2,GPM6A,NTRK2
1.034e-02	-4.57	positive regulation of cellular process	biological process	GO:0048522	5719	24	18204	50	NTRK2,PLCB1,NPAS3,CNTN1,GLIS3,SLC4A4,SORBS1,RORA,GPM6A,MACF1,SOX5,PARD3,HPSE2,APOE,RFX4,TNIK,SLC1A2,ERBB4,GPC5,TNC,CLU,GFAP,NRXN1,FMN2
1.036e-02	-4.57	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	50	PLCB1,RYR3
1.040e-02	-4.57	export from cell	biological process	GO:0140352	485	5	18204	50	SLC4A4,NTRK2,NRXN1,CAMK2G,ATP1A2
1.041e-02	-4.57	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	48	RYR3,MACF1,GPC5,PRKG1
1.042e-02	-4.56	BTN2A1 (butyrophilin subfamily 2 member A1)	protein interactions	11120	60	2	19454	50	FMN2,PLCB1
1.043e-02	-4.56	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	50	APOE
1.043e-02	-4.56	tenascin complex	cellular component	GO:0090733	4	1	19108	50	TNC
1.043e-02	-4.56	internode region of axon	cellular component	GO:0033269	4	1	19108	50	PARD3
1.045e-02	-4.56	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	2	10285	34	ADCY2,PLCB1
1.045e-02	-4.56	cellular localization	biological process	GO:0051641	2660	14	18204	50	GFAP,CLU,NRXN1,SLC14A1,MACF1,FMN2,PARD3,CAMK2G,DCLK2,APOE,SLC1A2,TNIK,LRP1B,ERBB4
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	GFAP,ATP1A2,SLC1A2
1.053e-02	-4.55	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	22	SLC1A2,CST3
1.053e-02	-4.55	side of membrane	cellular component	GO:0098552	715	6	19108	50	DTNA,LSAMP,CNTN1,NTM,GPC5,GFAP
1.055e-02	-4.55	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	43	GPM6A
1.055e-02	-4.55	VINCULIN_1	prosite domains	PS00663	3	1	12186	43	CTNNA2
1.055e-02	-4.55	SOHO	prosite domains	PS50831	3	1	12186	43	SORBS1
1.055e-02	-4.55	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	43	GPM6A
1.059e-02	-4.55	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	48	16828	48	RYR3,GPM6A,SORBS1,FMN2,GFAP,MGAT4C,MSI2,NTRK2,CNTN1,DGKG,CTNND2,NPAS3,PARD3,ADCY2,CDH20,TRPM3,SLC4A4,SOX5,ABLIM1,SLC14A1,DCLK2,TNIK,PLCB1,LRP1B,PITPNC1,ATP1A2,NRXN1,TNC,NKAIN3,APOE,SLC1A2,GLIS3,ERBB4,NAV2,DTNA,CAMK2G,GPC5,NTM,PRKG1,NEBL,MACF1,HPSE2,LSAMP,CLU,RORA,NRG3,RFX4,CST3
1.062e-02	-4.54	Glutamatergic synapse	KEGG pathways	hsa04724	114	3	7161	29	SLC1A2,ADCY2,PLCB1
1.062e-02	-4.54	Glutamatergic synapse	KEGG pathways	ko04724	114	3	7161	29	PLCB1,ADCY2,SLC1A2
1.063e-02	-4.54	neuron spine	cellular component	GO:0044309	174	3	19108	50	NTRK2,ATP1A2,GPM6A
1.072e-02	-4.54	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	50	RYR3,PLCB1
1.072e-02	-4.54	visual behavior	biological process	GO:0007632	57	2	18204	50	SLC1A2,ATP1A2
1.073e-02	-4.53	regulation of developmental growth	biological process	GO:0048638	314	4	18204	50	ERBB4,PLCB1,MACF1,APOE
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	PLC-beta_C_sf	interpro domains	IPR042531	4	1	18521	50	PLCB1
1.076e-02	-4.53	Glyco_transf_54	interpro domains	IPR006759	4	1	18521	50	MGAT4C
1.076e-02	-4.53	Tyr_kinase_EGF/ERB/XmrK_rcpt	interpro domains	IPR016245	4	1	18521	50	ERBB4
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	ApoA_E	interpro domains	IPR000074	4	1	18521	50	APOE
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	PLC-beta_PH	interpro domains	IPR037862	4	1	18521	50	PLCB1
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	Ca/CaM-dep_prot_kinase-assoc	interpro domains	IPR013543	4	1	18521	50	CAMK2G
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	PLC-beta	interpro domains	IPR016280	4	1	18521	50	PLCB1
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	TNIK,PRKG1
1.077e-02	-4.53	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	4	16828	48	GLIS3,MACF1,MGAT4C,NAV2
1.077e-02	-4.53	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	3	19454	50	NTRK2,NRG3,ERBB4
1.078e-02	-4.53	ribonucleotide binding	molecular function	GO:0032553	1888	11	18094	49	NAV2,MAPK10,DGKG,NTRK2,DCLK2,ERBB4,TNIK,CAMK2G,ADCY2,PRKG1,ATP1A2
1.079e-02	-4.53	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	49	APOE
1.079e-02	-4.53	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	49	RYR3
1.079e-02	-4.53	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	49	NTRK2
1.080e-02	-4.53	ACTB (actin beta)	protein interactions	60	958	7	19454	50	MACF1,NEBL,FMN2,DTNA,ABLIM1,SORBS1,APOE
1.080e-02	-4.53	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	50	DTNA,CTNNA2,CDH20
1.082e-02	-4.53	regulation of cell motility	biological process	GO:2000145	1122	8	18204	50	CTNNA2,PRKG1,MACF1,TNC,ERBB4,APOE,PLCB1,NRG3
1.082e-02	-4.53	positive regulation of cellular component organization	biological process	GO:0051130	1122	8	18204	50	CNTN1,GPM6A,MACF1,PLCB1,NRXN1,NTRK2,APOE,CLU
1.084e-02	-4.52	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	47	16828	48	NEBL,PRKG1,NTM,GPC5,DTNA,CAMK2G,NRG3,RFX4,RORA,LSAMP,CLU,MACF1,HPSE2,ATP1A2,PITPNC1,LRP1B,TNIK,PLCB1,NAV2,ERBB4,GLIS3,SLC1A2,APOE,NKAIN3,TNC,NRXN1,CDH20,ADCY2,PARD3,NPAS3,CTNND2,DCLK2,SLC14A1,ABLIM1,SOX5,SLC4A4,TRPM3,MGAT4C,GFAP,GPM6A,FMN2,SORBS1,RYR3,DGKG,CNTN1,NTRK2,MSI2
1.085e-02	-4.52	adrenal_cortical_adenoma	COSMIC cancer mutations	adrenal_cortical_adenoma	161	3	16828	48	ADCY2,FMN2,LRP1B
1.088e-02	-4.52	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	2	10285	34	ADCY2,PLCB1
1.088e-02	-4.52	FCERI mediated MAPK activation	REACTOME pathways	R-HSA-2871796	265	4	10285	34	NRG3,ERBB4,MAPK10,CAMK2G
1.094e-02	-4.52	negative regulation of protein kinase C signaling	biological process	GO:0090038	4	1	18204	50	DGKG
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.094e-02	-4.52	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	50	NTRK2
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.094e-02	-4.52	response to fluoride	biological process	GO:1902617	4	1	18204	50	PLCB1
1.094e-02	-4.52	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	50	NTRK2
1.094e-02	-4.52	cardiac muscle tissue regeneration	biological process	GO:0061026	4	1	18204	50	ERBB4
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	response to caloric restriction	biological process	GO:0061771	4	1	18204	50	APOE
1.094e-02	-4.52	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	50	CLU
1.094e-02	-4.52	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	50	APOE
1.094e-02	-4.52	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	50	APOE
1.094e-02	-4.52	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	50	APOE
1.094e-02	-4.52	regulation of systemic arterial blood pressure by baroreceptor feedback	biological process	GO:0003025	4	1	18204	50	NAV2
1.094e-02	-4.52	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	50	CST3
1.097e-02	-4.51	Glyco_transf_54	pfam domains	PF04666	4	1	17795	49	MGAT4C
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	Spectrin_3	pfam domains	PF21019	4	1	17795	49	MACF1
1.097e-02	-4.51	Spectrin_2	pfam domains	PF18373	4	1	17795	49	MACF1
1.097e-02	-4.51	PH_14	pfam domains	PF17787	4	1	17795	49	PLCB1
1.097e-02	-4.51	CaMKII_AD	pfam domains	PF08332	4	1	17795	49	CAMK2G
1.097e-02	-4.51	Apolipoprotein	pfam domains	PF01442	4	1	17795	49	APOE
1.097e-02	-4.51	AbLIM_anchor	pfam domains	PF16182	4	1	17795	49	ABLIM1
1.097e-02	-4.51	TRPM_tetra	pfam domains	PF16519	4	1	17795	49	TRPM3
1.097e-02	-4.51	Nebulin	pfam domains	PF00880	4	1	17795	49	NEBL
1.097e-02	-4.51	Spectrin_4	pfam domains	PF21020	4	1	17795	49	MACF1
1.102e-02	-4.51	positive regulation of developmental growth	biological process	GO:0048639	168	3	18204	50	PLCB1,ERBB4,MACF1
1.110e-02	-4.50	ARHGAP29 (Rho GTPase activating protein 29)	protein interactions	9411	62	2	19454	50	CAMK2G,PARD3
1.111e-02	-4.50	asymmetric synapse	cellular component	GO:0032279	333	4	19108	50	CTNND2,TNIK,ERBB4,NTRK2
1.117e-02	-4.49	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	48	PRKG1,GPM6A,GPC5,MACF1,RYR3
1.128e-02	-4.48	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	34	ATP1A2,CAMK2G,RYR3
1.132e-02	-4.48	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	41	16828	48	CNTN1,SLC1A2,TNC,NTRK2,NRXN1,DGKG,NAV2,ERBB4,GLIS3,LRP1B,TNIK,FMN2,GPM6A,PLCB1,SORBS1,RYR3,ATP1A2,MGAT4C,PITPNC1,RORA,ABLIM1,LSAMP,SOX5,SLC4A4,TRPM3,MACF1,HPSE2,DCLK2,CST3,RFX4,NRG3,PRKG1,PARD3,NTM,NPAS3,GPC5,CTNND2,DTNA,NEBL,CDH20,ADCY2
1.137e-02	-4.48	small molecule binding	molecular function	GO:0036094	6197	25	18094	49	MAPK10,DCLK2,ADCY2,RORA,APOE,GLIS3,PRKG1,DGKG,RYR3,LRP1B,ERBB4,MGAT4C,NRXN1,PITPNC1,NTRK2,NAV2,PLCB1,ABLIM1,DTNA,SLC1A2,ATP1A2,MACF1,PARD3,CAMK2G,TNIK
1.138e-02	-4.48	Sorb	smart domains	SM00459	3	1	9717	37	SORBS1
1.138e-02	-4.48	PLP	smart domains	SM00002	3	1	9717	37	GPM6A
1.142e-02	-4.47	cervix	COSMIC cancer mutations	cervix	11793	41	16828	48	RFX4,NRG3,CST3,DCLK2,MACF1,HPSE2,TRPM3,SOX5,SLC4A4,LSAMP,ABLIM1,RORA,ADCY2,CDH20,NEBL,DTNA,GPC5,CTNND2,NPAS3,NTM,PARD3,PRKG1,GLIS3,NAV2,DGKG,ERBB4,NRXN1,NTRK2,TNC,SLC1A2,CNTN1,PITPNC1,MGAT4C,ATP1A2,RYR3,SORBS1,PLCB1,FMN2,GPM6A,TNIK,LRP1B
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.144e-02	-4.47	PRPH (peripherin)	protein interactions	5630	182	3	19454	50	GFAP,SORBS1,ABLIM1
1.144e-02	-4.47	NLGN2 (neuroligin 2)	protein interactions	57555	63	2	19454	50	NRXN1,CLU
1.145e-02	-4.47	protein localization to synapse	biological process	GO:0035418	59	2	18204	50	NRXN1,ERBB4
1.145e-02	-4.47	ALB (albumin)	protein interactions	213	342	4	19454	50	APOE,CST3,DGKG,GFAP
1.163e-02	-4.45	back	COSMIC cancer mutations	back	310	4	16828	48	TNIK,ATP1A2,ERBB4,LRP1B
1.179e-02	-4.44	SYNC (syncoilin, intermediate filament protein)	protein interactions	81493	64	2	19454	50	DTNA,GFAP
1.182e-02	-4.44	regulation of smooth muscle contraction	biological process	GO:0006940	60	2	18204	50	ATP1A2,PRKG1
1.182e-02	-4.44	regulation of glucose import	biological process	GO:0046324	60	2	18204	50	SLC1A2,SORBS1
1.182e-02	-4.44	export across plasma membrane	biological process	GO:0140115	60	2	18204	50	ATP1A2,SLC4A4
1.182e-02	-4.44	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	50	ATP1A2,NTRK2
1.194e-02	-4.43	Neurotrophin signaling pathway	KEGG pathways	ko04722	119	3	7161	29	NTRK2,CAMK2G,MAPK10
1.194e-02	-4.43	Neurotrophin signaling pathway	KEGG pathways	hsa04722	119	3	7161	29	NTRK2,CAMK2G,MAPK10
1.204e-02	-4.42	protein phosphorylation	biological process	GO:0006468	503	5	18204	50	PRKG1,MAPK10,TNIK,NTRK2,ERBB4
1.204e-02	-4.42	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	5	16828	48	SLC4A4,LRP1B,CNTN1,LSAMP,RYR3
1.204e-02	-4.42	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	5	16828	48	RYR3,LSAMP,CNTN1,LRP1B,SLC4A4
1.205e-02	-4.42	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	48	16828	48	NAV2,ERBB4,GLIS3,SLC1A2,APOE,TNC,NKAIN3,NRXN1,ATP1A2,PITPNC1,LRP1B,TNIK,PLCB1,CST3,NRG3,RFX4,RORA,LSAMP,CLU,MACF1,HPSE2,NEBL,PRKG1,NTM,GPC5,CAMK2G,DTNA,DGKG,CNTN1,NTRK2,MSI2,MGAT4C,GFAP,FMN2,SORBS1,GPM6A,RYR3,DCLK2,SLC14A1,ABLIM1,SLC4A4,SOX5,TRPM3,CDH20,ADCY2,PARD3,NPAS3,CTNND2
1.216e-02	-4.41	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME pathways	R-HSA-112314	146	3	10285	34	ADCY2,PLCB1,CAMK2G
1.220e-02	-4.41	regulation of glycoprotein metabolic process	biological process	GO:1903018	61	2	18204	50	CST3,PLCB1
1.222e-02	-4.40	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	2	10285	34	ERBB4,NRG3
1.225e-02	-4.40	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	49	NTRK2,ERBB4
1.230e-02	-4.40	regulation of lipid metabolic process	biological process	GO:0019216	327	4	18204	50	SORBS1,RORA,APOE,PRKG1
1.234e-02	-4.39	salivary_gland-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma-adenoid_cystic_carcinoma	488	5	16828	48	RORA,PRKG1,MGAT4C,CTNND2,RYR3
1.238e-02	-4.39	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	45	TRPM3
1.238e-02	-4.39	-	gene3d domains	1.20.58.1060	4	1	14470	45	MACF1
1.238e-02	-4.39	Phospholipase C beta, distal C-terminal domain	gene3d domains	1.20.1230.10	4	1	14470	45	PLCB1
1.238e-02	-4.39	-	gene3d domains	2.30.29.240	4	1	14470	45	PLCB1
1.247e-02	-4.38	IGc2	smart domains	SM00408	239	4	9717	37	CNTN1,NTM,NTRK2,LSAMP
1.248e-02	-4.38	Vascular smooth muscle contraction	KEGG pathways	hsa04270	121	3	7161	29	PLCB1,ADCY2,PRKG1
1.248e-02	-4.38	Vascular smooth muscle contraction	KEGG pathways	ko04270	121	3	7161	29	PLCB1,ADCY2,PRKG1
1.249e-02	-4.38	central nervous system neuron differentiation	biological process	GO:0021953	176	3	18204	50	DCLK2,NTRK2,RORA
1.250e-02	-4.38	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	2	19454	50	CLU,APOE
1.253e-02	-4.38	postsynaptic specialization	cellular component	GO:0099572	345	4	19108	50	CTNND2,TNIK,ERBB4,NTRK2
1.271e-02	-4.37	cadherin binding	molecular function	GO:0045296	335	4	18094	49	MACF1,CTNNA2,CDH20,CTNND2
1.279e-02	-4.36	SYT13 (synaptotagmin 13)	protein interactions	57586	5	1	19454	50	NRXN1
1.279e-02	-4.36	PPP1R17 (protein phosphatase 1 regulatory subunit 17)	protein interactions	10842	5	1	19454	50	PRKG1
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.279e-02	-4.36	CAMK2N2 (calcium/calmodulin dependent protein kinase II inhibitor 2)	protein interactions	94032	5	1	19454	50	CAMK2G
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.279e-02	-4.36	NRG2 (neuregulin 2)	protein interactions	9542	5	1	19454	50	ERBB4
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	RVS161 (amphiphysin-like protein RVS161)	protein interactions	850367	5	1	19454	50	GFAP
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.281e-02	-4.36	skin-upper_back-malignant_melanoma	COSMIC cancer mutations	skin-upper_back-malignant_melanoma	319	4	16828	48	CNTN1,ERBB4,MACF1,GPC5
1.287e-02	-4.35	SHC3 (SHC adaptor protein 3)	protein interactions	53358	67	2	19454	50	NTRK2,ERBB4
1.287e-02	-4.35	PARD6A (par-6 family cell polarity regulator alpha)	protein interactions	50855	67	2	19454	50	PARD3,PLCB1
1.287e-02	-4.35	ARMC1 (armadillo repeat containing 1)	protein interactions	55156	67	2	19454	50	CNTN1,GPM6A
1.298e-02	-4.34	regulation of nitric oxide biosynthetic process	biological process	GO:0045428	63	2	18204	50	APOE,CLU
1.302e-02	-4.34	calcium- and calmodulin-dependent protein kinase complex	cellular component	GO:0005954	5	1	19108	50	CAMK2G
1.302e-02	-4.34	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	50	CLU
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	NEBL,SORBS1
1.305e-02	-4.34	Platelet activation	KEGG pathways	hsa04611	123	3	7161	29	PRKG1,ADCY2,PLCB1
1.310e-02	-4.34	temporoparietal	COSMIC cancer mutations	temporoparietal	61	2	16828	48	PARD3,RYR3
1.310e-02	-4.34	central_nervous_system-cerebrum-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-cerebrum-glioma-astrocytoma_Grade_IV	61	2	16828	48	LRP1B,CNTN1
1.313e-02	-4.33	response to endogenous stimulus	biological process	GO:0009719	1402	9	18204	50	RYR3,SOX5,TNC,ERBB4,ATP1A2,SORBS1,PLCB1,SLC1A2,NTRK2
1.314e-02	-4.33	inorganic ion transmembrane transport	biological process	GO:0098660	715	6	18204	50	PLCB1,SLC4A4,TRPM3,ATP1A2,RYR3,GPM6A
1.316e-02	-4.33	Metabolism of fat-soluble vitamins	REACTOME pathways	R-HSA-6806667	53	2	10285	34	GPC5,APOE
1.316e-02	-4.33	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	1	10285	34	SLC1A2
1.316e-02	-4.33	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	1	10285	34	SLC1A2
1.324e-02	-4.32	PLCH1 (phospholipase C eta 1)	protein interactions	23007	68	2	19454	50	NTRK2,PARD3
1.331e-02	-4.32	regulation of locomotion	biological process	GO:0040012	1164	8	18204	50	PLCB1,NRG3,APOE,TNC,ERBB4,CTNNA2,PRKG1,MACF1
1.332e-02	-4.32	human chr4q21.3	chromosome location	human chr4q21.3	7	1	26134	50	MAPK10
1.336e-02	-4.32	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	4	16828	48	LRP1B,SORBS1,NTM,ADCY2
1.337e-02	-4.31	dendrite morphogenesis	biological process	GO:0048813	64	2	18204	50	CTNNA2,CTNND2
1.337e-02	-4.31	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	50	SORBS1,FMN2
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	EGF_Tenascin	interpro domains	IPR041161	5	1	18521	50	TNC
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.347e-02	-4.31	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	1	18094	49	SLC1A2
1.347e-02	-4.31	neuroligin family protein binding	molecular function	GO:0097109	5	1	18094	49	NRXN1
1.347e-02	-4.31	syndecan binding	molecular function	GO:0045545	5	1	18094	49	TNC
1.347e-02	-4.31	glutamate:sodium symporter activity	molecular function	GO:0015501	5	1	18094	49	SLC1A2
1.347e-02	-4.31	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	49	NTRK2
1.354e-02	-4.30	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	6	19454	50	MSI2,CLU,NTRK2,GFAP,ERBB4,SLC1A2
1.363e-02	-4.30	Heparan sulfate/heparin (HS-GAG) metabolism	REACTOME pathways	R-HSA-1638091	54	2	10285	34	GPC5,HPSE2
1.366e-02	-4.29	stem cell differentiation	biological process	GO:0048863	182	3	18204	50	GPM6A,MSI2,ERBB4
1.366e-02	-4.29	response to prostaglandin D	biological process	GO:0071798	5	1	18204	50	TNC
1.366e-02	-4.29	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	50	APOE
1.366e-02	-4.29	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	50	APOE
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	ERBB2-ERBB4 signaling pathway	biological process	GO:0038135	5	1	18204	50	ERBB4
1.366e-02	-4.29	gephyrin clustering involved in postsynaptic density assembly	biological process	GO:0097116	5	1	18204	50	NRXN1
1.366e-02	-4.29	cellular response to prostaglandin D stimulus	biological process	GO:0071799	5	1	18204	50	TNC
1.366e-02	-4.29	glossopharyngeal nerve development	biological process	GO:0021563	5	1	18204	50	NAV2
1.366e-02	-4.29	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	50	APOE
1.366e-02	-4.29	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	50	CLU
1.366e-02	-4.29	negative regulation of glutamate secretion	biological process	GO:0014050	5	1	18204	50	PRKG1
1.366e-02	-4.29	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	50	NTRK2
1.366e-02	-4.29	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	50	FMN2
1.366e-02	-4.29	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	50	APOE
1.366e-02	-4.29	activation of meiosis	biological process	GO:0090427	5	1	18204	50	PLCB1
1.369e-02	-4.29	EGF_Tenascin	pfam domains	PF18720	5	1	17795	49	TNC
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.369e-02	-4.29	Vinculin	pfam domains	PF01044	5	1	17795	49	CTNNA2
1.369e-02	-4.29	main axon	cellular component	GO:0044304	68	2	19108	50	SLC1A2,PARD3
1.371e-02	-4.29	ALPHACATENIN	prints domains	PR00805	4	1	5227	18	CTNNA2
1.377e-02	-4.29	positive regulation of synapse assembly	biological process	GO:0051965	65	2	18204	50	NRXN1,NTRK2
1.377e-02	-4.29	long-term synaptic potentiation	biological process	GO:0060291	65	2	18204	50	NTRK2,GFAP
1.377e-02	-4.29	regulation of nitric oxide metabolic process	biological process	GO:0080164	65	2	18204	50	APOE,CLU
1.377e-02	-4.29	apoptotic mitochondrial changes	biological process	GO:0008637	65	2	18204	50	CLU,ERBB4
1.389e-02	-4.28	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	50	CTNND2,MACF1,APOE,GPC5
1.399e-02	-4.27	PCDH20 (protocadherin 20)	protein interactions	64881	70	2	19454	50	MGAT4C,CTNNA2
1.399e-02	-4.27	DUSP10 (dual specificity phosphatase 10)	protein interactions	11221	70	2	19454	50	ERBB4,MAPK10
1.399e-02	-4.27	MTMR9 (myotubularin related protein 9)	protein interactions	66036	70	2	19454	50	CLU,ERBB4
1.404e-02	-4.27	NEBULIN	prosite domains	PS51216	4	1	12186	43	NEBL
1.406e-02	-4.26	upper_back	COSMIC cancer mutations	upper_back	328	4	16828	48	CNTN1,ERBB4,GPC5,MACF1
1.407e-02	-4.26	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	5	19454	50	PARD3,PLCB1,FMN2,MACF1,DTNA
1.414e-02	-4.26	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	3	19454	50	ERBB4,NTRK2,NEBL
1.418e-02	-4.26	ERBB signaling pathway	biological process	GO:0038127	66	2	18204	50	ERBB4,NRG3
1.418e-02	-4.26	cardiac muscle cell development	biological process	GO:0055013	66	2	18204	50	NEBL,PRKG1
1.424e-02	-4.25	EGF	pfam domains	PF00008	66	2	17795	49	LRP1B,NRXN1
1.425e-02	-4.25	DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5)	protein interactions	80331	365	4	19454	50	DTNA,CLU,PARD3,MACF1
1.425e-02	-4.25	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	5	16828	48	PRKG1,TNC,MGAT4C,SLC14A1,NPAS3
1.426e-02	-4.25	purine nucleotide binding	molecular function	GO:0017076	1964	11	18094	49	DCLK2,ERBB4,MAPK10,NAV2,NTRK2,DGKG,PRKG1,ATP1A2,TNIK,ADCY2,CAMK2G
1.435e-02	-4.24	skin-ankle-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-ankle-malignant_melanoma-acral_lentiginous	330	4	16828	48	PLCB1,ERBB4,PARD3,NRG3
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	PARD3,MACF1
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	TNIK,GPM6A
1.437e-02	-4.24	Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME pathways	R-HSA-881907	443	5	10285	34	CAMK2G,PLCB1,NRG3,DGKG,ERBB4
1.450e-02	-4.23	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	4	16828	48	ADCY2,LRP1B,SORBS1,NTM
1.458e-02	-4.23	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	47	16828	48	SLC14A1,DCLK2,TRPM3,ABLIM1,SOX5,SLC4A4,CDH20,ADCY2,NPAS3,CTNND2,PARD3,DGKG,MSI2,CNTN1,NTRK2,MGAT4C,RYR3,GFAP,FMN2,GPM6A,SORBS1,NRG3,RFX4,CST3,HPSE2,MACF1,RORA,LSAMP,CLU,NEBL,GPC5,CAMK2G,PRKG1,NTM,GLIS3,ERBB4,NAV2,NRXN1,SLC1A2,APOE,NKAIN3,TNC,ATP1A2,PITPNC1,LRP1B,PLCB1,TNIK
1.459e-02	-4.23	cholesterol transport	biological process	GO:0030301	67	2	18204	50	APOE,CLU
1.466e-02	-4.22	CH	pfam domains	PF00307	67	2	17795	49	MACF1,NAV2
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	47	16828	48	TRPM3,ABLIM1,SOX5,SLC4A4,SLC14A1,DCLK2,CTNND2,NPAS3,PARD3,CDH20,ADCY2,MSI2,CNTN1,NTRK2,DGKG,RYR3,FMN2,GPM6A,SORBS1,GFAP,MGAT4C,MACF1,HPSE2,LSAMP,CLU,RORA,NRG3,RFX4,CST3,GPC5,DTNA,CAMK2G,PRKG1,NTM,NEBL,NRXN1,TNC,APOE,SLC1A2,GLIS3,ERBB4,NAV2,LRP1B,TNIK,PLCB1,PITPNC1,ATP1A2
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	47	16828	48	TNIK,PLCB1,LRP1B,PITPNC1,ATP1A2,NRXN1,TNC,APOE,SLC1A2,GLIS3,NAV2,ERBB4,CAMK2G,DTNA,GPC5,NTM,PRKG1,NEBL,HPSE2,MACF1,CLU,LSAMP,RORA,NRG3,RFX4,CST3,RYR3,SORBS1,GPM6A,FMN2,GFAP,MGAT4C,MSI2,NTRK2,CNTN1,DGKG,CTNND2,NPAS3,PARD3,ADCY2,CDH20,TRPM3,SLC4A4,SOX5,ABLIM1,SLC14A1,DCLK2
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	47	16828	48	DGKG,CNTN1,NTRK2,MSI2,MGAT4C,GPM6A,FMN2,SORBS1,GFAP,RYR3,DCLK2,SLC14A1,ABLIM1,SLC4A4,SOX5,TRPM3,CDH20,ADCY2,PARD3,CTNND2,NPAS3,NAV2,ERBB4,GLIS3,TNC,APOE,SLC1A2,NRXN1,PITPNC1,ATP1A2,LRP1B,PLCB1,TNIK,CST3,RFX4,NRG3,LSAMP,CLU,RORA,HPSE2,MACF1,NEBL,PRKG1,NTM,GPC5,CAMK2G,DTNA
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	47	16828	48	SOX5,SLC4A4,ABLIM1,TRPM3,DCLK2,SLC14A1,PARD3,CTNND2,NPAS3,ADCY2,CDH20,NTRK2,CNTN1,MSI2,DGKG,GPM6A,FMN2,SORBS1,GFAP,RYR3,MGAT4C,LSAMP,CLU,RORA,HPSE2,MACF1,CST3,RFX4,NRG3,NTM,PRKG1,DTNA,CAMK2G,GPC5,NEBL,TNC,APOE,SLC1A2,NRXN1,NAV2,ERBB4,GLIS3,TNIK,PLCB1,LRP1B,PITPNC1,ATP1A2
1.474e-02	-4.22	classic	COSMIC cancer mutations	classic	14774	47	16828	48	PARD3,NPAS3,CTNND2,ADCY2,CDH20,SLC4A4,SOX5,ABLIM1,TRPM3,DCLK2,SLC14A1,GFAP,FMN2,SORBS1,GPM6A,RYR3,MGAT4C,NTRK2,CNTN1,MSI2,DGKG,NTM,PRKG1,CAMK2G,DTNA,GPC5,NEBL,RORA,CLU,LSAMP,HPSE2,MACF1,CST3,NRG3,RFX4,TNIK,PLCB1,LRP1B,ATP1A2,PITPNC1,SLC1A2,APOE,TNC,NRXN1,ERBB4,NAV2,GLIS3
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	TNIK,GPM6A
1.476e-02	-4.22	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	50	PARD3,ABLIM1
1.490e-02	-4.21	medulla	COSMIC cancer mutations	medulla	14778	47	16828	48	PITPNC1,ATP1A2,LRP1B,PLCB1,TNIK,GLIS3,ERBB4,NAV2,NRXN1,APOE,TNC,SLC1A2,NEBL,GPC5,DTNA,CAMK2G,PRKG1,NTM,NRG3,RFX4,CST3,MACF1,HPSE2,CLU,LSAMP,RORA,MGAT4C,RYR3,SORBS1,FMN2,GPM6A,GFAP,DGKG,MSI2,CNTN1,NTRK2,CDH20,ADCY2,CTNND2,NPAS3,PARD3,SLC14A1,DCLK2,TRPM3,ABLIM1,SOX5,SLC4A4
1.495e-02	-4.20	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	47	16828	48	DGKG,NTRK2,CNTN1,MSI2,MGAT4C,GFAP,FMN2,GPM6A,SORBS1,RYR3,DCLK2,SLC14A1,SOX5,SLC4A4,ABLIM1,TRPM3,ADCY2,CDH20,PARD3,NPAS3,CTNND2,NAV2,ERBB4,GLIS3,SLC1A2,APOE,TNC,NRXN1,ATP1A2,PITPNC1,PLCB1,TNIK,LRP1B,CST3,NRG3,RFX4,RORA,CLU,LSAMP,MACF1,HPSE2,NEBL,NTM,PRKG1,CAMK2G,DTNA,GPC5
1.501e-02	-4.20	actin filament bundle organization	biological process	GO:0061572	68	2	18204	50	FMN2,SORBS1
1.502e-02	-4.20	regulation of protein metabolic process	biological process	GO:0051246	2218	12	18204	50	ERBB4,RFX4,APOE,TNIK,NTRK2,PLCB1,MSI2,FMN2,PARD3,CLU,CST3,GFAP
1.510e-02	-4.19	regulation of lipid biosynthetic process	biological process	GO:0046890	189	3	18204	50	APOE,PRKG1,SORBS1
1.512e-02	-4.19	neuron to neuron synapse	cellular component	GO:0098984	365	4	19108	50	CTNND2,NTRK2,TNIK,ERBB4
1.514e-02	-4.19	Dopaminergic synapse	KEGG pathways	ko04728	130	3	7161	29	PLCB1,CAMK2G,MAPK10
1.514e-02	-4.19	Dopaminergic synapse	KEGG pathways	hsa04728	130	3	7161	29	MAPK10,CAMK2G,PLCB1
1.515e-02	-4.19	NEBU	smart domains	SM00227	4	1	9717	37	NEBL
1.526e-02	-4.18	cellular response to lipid	biological process	GO:0071396	534	5	18204	50	RORA,ATP1A2,ADCY2,TNC,PLCB1
1.528e-02	-4.18	neoplasm	COSMIC cancer mutations	neoplasm	14787	47	16828	48	LRP1B,PLCB1,TNIK,ATP1A2,NRXN1,APOE,TNC,NKAIN3,SLC1A2,GLIS3,NAV2,ERBB4,GPC5,DTNA,CAMK2G,PRKG1,NTM,NEBL,HPSE2,MACF1,CLU,LSAMP,RORA,RFX4,NRG3,CST3,RYR3,SORBS1,FMN2,GPM6A,GFAP,MGAT4C,MSI2,CNTN1,NTRK2,DGKG,CTNND2,NPAS3,PARD3,CDH20,ADCY2,TRPM3,ABLIM1,SOX5,SLC4A4,SLC14A1,DCLK2
1.529e-02	-4.18	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	hsa04961	47	2	7161	29	ATP1A2,PLCB1
1.529e-02	-4.18	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	ko04961	47	2	7161	29	PLCB1,ATP1A2
1.531e-02	-4.18	pallium development	biological process	GO:0021543	190	3	18204	50	PLCB1,DCLK2,NTRK2
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	SYTL3 (synaptotagmin like 3)	protein interactions	94120	6	1	19454	50	NRXN1
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	CIBAR2 (CBY1 interacting BAR domain containing 2)	protein interactions	339145	6	1	19454	50	CAMK2G
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	Rara (retinoic acid receptor, alpha)	protein interactions	19401	6	1	19454	50	MAPK10
1.532e-02	-4.18	NRG4 (neuregulin 4)	protein interactions	145957	6	1	19454	50	ERBB4
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	50	APOE
1.532e-02	-4.18	LBX2 (ladybird homeobox 2)	protein interactions	85474	6	1	19454	50	GFAP
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	50	APOE
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	SMOC2 (SPARC related modular calcium binding 2)	protein interactions	64094	6	1	19454	50	TNC
1.535e-02	-4.18	Immunoglobulin	interpro domains	IPR013151	70	2	18521	50	CNTN1,NTM
1.541e-02	-4.17	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	5	19454	50	PARD3,TNIK,MACF1,ERBB4,DTNA
1.543e-02	-4.17	regulation of blood coagulation	biological process	GO:0030193	69	2	18204	50	APOE,PRKG1
1.544e-02	-4.17	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	6	18094	49	ATP1A2,SLC1A2,GPM6A,TRPM3,SLC4A4,RYR3
1.546e-02	-4.17	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	45	APOE
1.546e-02	-4.17	-	gene3d domains	6.10.140.620	5	1	14470	45	CAMK2G
1.550e-02	-4.17	LIM	pfam domains	PF00412	69	2	17795	49	ABLIM1,NEBL
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	NRXN1,ABLIM1,DTNA
1.554e-02	-4.16	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	2	19454	50	ERBB4,MSI2
1.560e-02	-4.16	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	50	APOE
1.560e-02	-4.16	PAR polarity complex	cellular component	GO:0120157	6	1	19108	50	PARD3
1.561e-02	-4.16	monoatomic ion transport	biological process	GO:0006811	964	7	18204	50	ATP1A2,RYR3,GPM6A,PLCB1,SLC4A4,SLC1A2,TRPM3
1.562e-02	-4.16	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	34	CAMK2G,ATP1A2
1.566e-02	-4.16	cerebrum	COSMIC cancer mutations	cerebrum	67	2	16828	48	CNTN1,LRP1B
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	NEBL,ABLIM1
1.585e-02	-4.14	negative regulation of smooth muscle cell proliferation	biological process	GO:0048662	70	2	18204	50	APOE,PRKG1
1.592e-02	-4.14	ig	pfam domains	PF00047	70	2	17795	49	NTM,CNTN1
1.594e-02	-4.14	HDAC9 (histone deacetylase 9)	protein interactions	9734	75	2	19454	50	GFAP,MAPK10
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	GF_recep_IV	interpro domains	IPR032778	6	1	18521	50	ERBB4
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY2
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	Syndecan/Neurexin_dom	interpro domains	IPR027789	6	1	18521	50	NRXN1
1.614e-02	-4.13	steroid hormone binding	molecular function	GO:1990239	6	1	18094	49	ATP1A2
1.614e-02	-4.13	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	49	RYR3
1.614e-02	-4.13	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	49	SLC4A4
1.614e-02	-4.13	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	49	APOE
1.628e-02	-4.12	regulation of hemostasis	biological process	GO:1900046	71	2	18204	50	PRKG1,APOE
1.629e-02	-4.12	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	50	PARD3,CNTN1,MACF1,PRKG1
1.633e-02	-4.11	RYK (receptor like tyrosine kinase)	protein interactions	6259	208	3	19454	50	CLU,CNTN1,CTNNA2
1.633e-02	-4.11	BCL2L1 (BCL2 like 1)	protein interactions	598	208	3	19454	50	RYR3,CLU,ABLIM1
1.634e-02	-4.11	regulation of body fluid levels	biological process	GO:0050878	356	4	18204	50	APOE,PRKG1,ERBB4,DGKG
1.637e-02	-4.11	cellular response to ether	biological process	GO:0071362	6	1	18204	50	PLCB1
1.637e-02	-4.11	vocal learning	biological process	GO:0042297	6	1	18204	50	NRXN1
1.637e-02	-4.11	imitative learning	biological process	GO:0098596	6	1	18204	50	NRXN1
1.637e-02	-4.11	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	50	CST3
1.637e-02	-4.11	mammary gland formation	biological process	GO:0060592	6	1	18204	50	NRG3
1.637e-02	-4.11	relaxation of vascular associated smooth muscle	biological process	GO:0060087	6	1	18204	50	PRKG1
1.637e-02	-4.11	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	50	APOE
1.637e-02	-4.11	inositol trisphosphate metabolic process	biological process	GO:0032957	6	1	18204	50	PLCB1
1.637e-02	-4.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	1	18204	50	SLC1A2
1.637e-02	-4.11	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	50	FMN2
1.637e-02	-4.11	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	50	APOE
1.637e-02	-4.11	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	50	CLU
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	postsynaptic density protein 95 clustering	biological process	GO:0097119	6	1	18204	50	NRXN1
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	RYR3
1.641e-02	-4.11	EF-hand_2	pfam domains	PF09068	6	1	17795	49	DTNA
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	RYR3
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY2
1.641e-02	-4.11	EF-hand_3	pfam domains	PF09069	6	1	17795	49	DTNA
1.641e-02	-4.11	Plectin	pfam domains	PF00681	6	1	17795	49	MACF1
1.641e-02	-4.11	GAS2	pfam domains	PF02187	6	1	17795	49	MACF1
1.641e-02	-4.11	GF_recep_IV	pfam domains	PF14843	6	1	17795	49	ERBB4
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	RYR3
1.641e-02	-4.11	Syndecan	pfam domains	PF01034	6	1	17795	49	NRXN1
1.641e-02	-4.11	SH3_10	pfam domains	PF17902	6	1	17795	49	MACF1
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.642e-02	-4.11	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	34	NTRK2
1.664e-02	-4.10	cell-cell adhesion	biological process	GO:0098609	546	5	18204	50	CTNND2,CDH20,CTNNA2,NRXN1,CNTN1
1.676e-02	-4.09	ADGRL2 (adhesion G protein-coupled receptor L2)	protein interactions	23266	77	2	19454	50	NTRK2,PARD3
1.676e-02	-4.09	actin cytoskeleton organization	biological process	GO:0030036	547	5	18204	50	TNIK,NEBL,FMN2,SORBS1,PRKG1
1.691e-02	-4.08	sarcoplasmic reticulum	cellular component	GO:0016529	76	2	19108	50	CAMK2G,RYR3
1.711e-02	-4.07	PITRANSFER	prints domains	PR00391	5	1	5227	18	PITPNC1
1.711e-02	-4.07	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	18	SLC4A4
1.716e-02	-4.07	negative regulation of wound healing	biological process	GO:0061045	73	2	18204	50	PRKG1,APOE
1.716e-02	-4.07	cardiac cell development	biological process	GO:0055006	73	2	18204	50	NEBL,PRKG1
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	SOX5,MSI2
1.717e-02	-4.06	IFIT3 (interferon induced protein with tetratricopeptide repeats 3)	protein interactions	3437	78	2	19454	50	ATP1A2,APOE
1.717e-02	-4.06	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	50	APOE,CLU
1.717e-02	-4.06	ATOH1 (atonal bHLH transcription factor 1)	protein interactions	474	78	2	19454	50	MACF1,GFAP
1.717e-02	-4.06	regulation of multicellular organismal process	biological process	GO:0051239	3113	15	18204	50	GFAP,RORA,ATP1A2,CST3,CLU,NRXN1,PRKG1,MACF1,PARD3,SOX5,CAMK2G,APOE,PLCB1,NTRK2,ERBB4
1.719e-02	-4.06	Ca2+ pathway	REACTOME pathways	R-HSA-4086398	61	2	10285	34	PLCB1,PRKG1
1.731e-02	-4.06	regulation of developmental process	biological process	GO:0050793	2540	13	18204	50	NRXN1,RORA,GFAP,CST3,SOX5,PARD3,MACF1,PLCB1,DGKG,NTRK2,TNIK,APOE,ERBB4
1.731e-02	-4.06	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	3	18204	50	ERBB4,NTRK2,APOE
1.737e-02	-4.05	regulation of cellular process	biological process	GO:0050794	11468	39	18204	50	ADCY2,SLC4A4,GLIS3,CNTN1,DTNA,NPAS3,PLCB1,PITPNC1,NTRK2,CTNNA2,PRKG1,CTNND2,GPM6A,MACF1,PARD3,HPSE2,SOX5,CAMK2G,DCLK2,ATP1A2,RORA,SORBS1,CST3,NRG3,MAPK10,TNC,ERBB4,GPC5,RFX4,APOE,SLC1A2,DGKG,TNIK,MSI2,RYR3,FMN2,GFAP,CLU,NRXN1
1.744e-02	-4.05	Activation of PKC Through G Protein-Coupled Receptor	SMPDB pathways	SMP0000749	4	1	1369	6	PLCB1
1.759e-02	-4.04	KRTAP3-2 (keratin associated protein 3-2)	protein interactions	83897	79	2	19454	50	GFAP,NTM
1.759e-02	-4.04	chondrosarcoma	COSMIC cancer mutations	chondrosarcoma	1181	8	16828	48	HPSE2,SLC4A4,CNTN1,LSAMP,LRP1B,ADCY2,NAV2,ERBB4
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	ERBB4,TNIK,NTRK2
1.761e-02	-4.04	regulation of coagulation	biological process	GO:0050818	74	2	18204	50	APOE,PRKG1
1.761e-02	-4.04	sterol transport	biological process	GO:0015918	74	2	18204	50	CLU,APOE
1.765e-02	-4.04	animal organ morphogenesis	biological process	GO:0009887	988	7	18204	50	NTRK2,ABLIM1,NRG3,CTNNA2,ERBB4,TNC,SOX5
1.775e-02	-4.03	Apelin signaling pathway	KEGG pathways	hsa04371	138	3	7161	29	PLCB1,ADCY2,RYR3
1.776e-02	-4.03	GABA-ergic synapse	cellular component	GO:0098982	78	2	19108	50	PLCB1,ERBB4
1.783e-02	-4.03	other	COSMIC cancer mutations	other	14843	47	16828	48	NRG3,RFX4,CST3,HPSE2,MACF1,RORA,LSAMP,CLU,NEBL,GPC5,CAMK2G,DTNA,PRKG1,NTM,GLIS3,NAV2,ERBB4,NRXN1,SLC1A2,APOE,TNC,NKAIN3,ATP1A2,LRP1B,PLCB1,TNIK,SLC14A1,DCLK2,TRPM3,ABLIM1,SLC4A4,SOX5,CDH20,ADCY2,NPAS3,CTNND2,PARD3,DGKG,MSI2,CNTN1,NTRK2,MGAT4C,RYR3,GFAP,SORBS1,FMN2,GPM6A
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.791e-02	-4.02	monoatomic cation transport	biological process	GO:0006812	766	6	18204	50	RYR3,GPM6A,ATP1A2,TRPM3,PLCB1,SLC4A4
1.793e-02	-4.02	large_cell	COSMIC cancer mutations	large_cell	14845	47	16828	48	TRPM3,SOX5,SLC4A4,ABLIM1,SLC14A1,DCLK2,NPAS3,CTNND2,PARD3,ADCY2,CDH20,MSI2,NTRK2,CNTN1,DGKG,RYR3,GFAP,SORBS1,FMN2,GPM6A,MGAT4C,HPSE2,MACF1,RORA,CLU,LSAMP,RFX4,NRG3,CST3,CAMK2G,DTNA,GPC5,NTM,PRKG1,NEBL,NRXN1,SLC1A2,APOE,TNC,GLIS3,ERBB4,NAV2,TNIK,PLCB1,LRP1B,ATP1A2,PITPNC1
1.794e-02	-4.02	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	72	2	16828	48	LRP1B,FMN2
1.794e-02	-4.02	cortisol_producing	COSMIC cancer mutations	cortisol_producing	72	2	16828	48	FMN2,LRP1B
1.795e-02	-4.02	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	9	16828	48	ATP1A2,PITPNC1,RFX4,CLU,SLC4A4,SLC1A2,NTRK2,FMN2,CTNND2
1.795e-02	-4.02	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	9	16828	48	CTNND2,CLU,SLC4A4,SLC1A2,FMN2,NTRK2,RFX4,ATP1A2,PITPNC1
1.801e-02	-4.02	MAP2 (microtubule associated protein 2)	protein interactions	4133	80	2	19454	50	APOE,GPM6A
1.825e-02	-4.00	calmodulin binding	molecular function	GO:0005516	206	3	18094	49	RYR3,CAMK2G,PLCB1
1.841e-02	-3.99	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	48	MACF1,NAV2
1.850e-02	-3.99	PRKCA (protein kinase C alpha)	protein interactions	5578	395	4	19454	50	GFAP,PLCB1,GPM6A,PRKG1
1.852e-02	-3.99	regulation of axon extension	biological process	GO:0030516	76	2	18204	50	APOE,MACF1
1.852e-02	-3.99	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	45	MACF1
1.852e-02	-3.99	Single helix bin	gene3d domains	1.20.5.490	6	1	14470	45	PRKG1
1.852e-02	-3.99	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	45	RYR3
1.852e-02	-3.99	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	45	MACF1
1.875e-02	-3.98	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Intermed_filament_DNA-bd	interpro domains	IPR006821	7	1	18521	50	GFAP
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Furin-like_Cys-rich_dom	interpro domains	IPR006211	7	1	18521	50	ERBB4
1.875e-02	-3.98	Rcpt_L-dom_sf	interpro domains	IPR036941	7	1	18521	50	ERBB4
1.875e-02	-3.98	Ammonium/urea_transptr	interpro domains	IPR029020	7	1	18521	50	SLC14A1
1.875e-02	-3.98	Rcpt_L-dom	interpro domains	IPR000494	7	1	18521	50	ERBB4
1.875e-02	-3.98	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	1	18521	50	SLC1A2
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.881e-02	-3.97	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	49	ATP1A2
1.881e-02	-3.97	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	49	PITPNC1
1.881e-02	-3.97	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	49	ATP1A2
1.881e-02	-3.97	mitogen-activated protein kinase p38 binding	molecular function	GO:0048273	7	1	18094	49	PRKG1
1.881e-02	-3.97	calcium-dependent protein serine/threonine phosphatase activity	molecular function	GO:0004723	7	1	18094	49	CAMK2G
1.889e-02	-3.97	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	48	MACF1,NAV2
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.898e-02	-3.96	regulation of organic acid transport	biological process	GO:0032890	77	2	18204	50	ATP1A2,PRKG1
1.898e-02	-3.96	neural retina development	biological process	GO:0003407	77	2	18204	50	NTRK2,GPM6A
1.898e-02	-3.96	cellular response to interleukin-1	biological process	GO:0071347	77	2	18204	50	RORA,PLCB1
1.898e-02	-3.96	regulation of synaptic transmission, glutamatergic	biological process	GO:0051966	77	2	18204	50	ATP1A2,NRXN1
1.898e-02	-3.96	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	50	NTRK2,MACF1
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	50	CLU
1.907e-02	-3.96	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	50	APOE
1.907e-02	-3.96	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	50	APOE
1.907e-02	-3.96	regulation of monocyte extravasation	biological process	GO:2000437	7	1	18204	50	PLCB1
1.907e-02	-3.96	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	50	APOE
1.907e-02	-3.96	observational learning	biological process	GO:0098597	7	1	18204	50	NRXN1
1.907e-02	-3.96	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	50	NRG3
1.907e-02	-3.96	peripheral nervous system axon regeneration	biological process	GO:0014012	7	1	18204	50	TNC
1.907e-02	-3.96	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	50	CTNNA2
1.907e-02	-3.96	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	50	FMN2
1.907e-02	-3.96	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	50	FMN2
1.907e-02	-3.96	relaxation of smooth muscle	biological process	GO:0044557	7	1	18204	50	PRKG1
1.907e-02	-3.96	regulation of testosterone biosynthetic process	biological process	GO:2000224	7	1	18204	50	PRKG1
1.912e-02	-3.96	Recep_L_domain	pfam domains	PF01030	7	1	17795	49	ERBB4
1.912e-02	-3.96	Furin-like	pfam domains	PF00757	7	1	17795	49	ERBB4
1.912e-02	-3.96	Filament_head	pfam domains	PF04732	7	1	17795	49	GFAP
1.912e-02	-3.96	SDF	pfam domains	PF00375	7	1	17795	49	SLC1A2
1.923e-02	-3.95	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	5	10285	34	CAMK2G,NRG3,ERBB4,NTRK2,ADCY2
1.930e-02	-3.95	SYT1 (synaptotagmin 1)	protein interactions	6857	83	2	19454	50	NRXN1,GPM6A
1.937e-02	-3.94	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	34	ERBB4,NRG3
1.944e-02	-3.94	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	2	18204	50	SORBS1,SLC4A4
1.944e-02	-3.94	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	50	SLC1A2,SORBS1
1.947e-02	-3.94	cytoskeleton	cellular component	GO:0005856	2412	12	19108	50	CLU,GFAP,DGKG,DTNA,FMN2,SORBS1,TNIK,PARD3,CTNNA2,NEBL,ABLIM1,MACF1
1.950e-02	-3.94	Wnt signaling pathway	KEGG pathways	hsa04310	143	3	7161	29	PLCB1,CAMK2G,MAPK10
1.950e-02	-3.94	Wnt signaling pathway	KEGG pathways	ko04310	143	3	7161	29	PLCB1,MAPK10,CAMK2G
1.956e-02	-3.93	structural molecule activity	molecular function	GO:0005198	793	6	18094	49	GFAP,APOE,CTNNA2,MACF1,NEBL,TNC
1.968e-02	-3.93	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	34	NTRK2
1.974e-02	-3.93	PSEN2 (presenilin 2)	protein interactions	5664	84	2	19454	50	GFAP,CTNND2
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	ERBB4,NTRK2
1.985e-02	-3.92	solute:sodium symporter activity	molecular function	GO:0015370	80	2	18094	49	SLC1A2,SLC4A4
1.990e-02	-3.92	Regulation of lipolysis in adipocytes	KEGG pathways	hsa04923	54	2	7161	29	PRKG1,ADCY2
1.991e-02	-3.92	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	5	19454	50	TNIK,PARD3,CLU,ABLIM1,DTNA
1.996e-02	-3.91	caveola	cellular component	GO:0005901	83	2	19108	50	SORBS1,ATP1A2
2.015e-02	-3.90	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	48	ERBB4,SLC4A4,PLCB1,FMN2,LRP1B
2.021e-02	-3.90	CH_dom	interpro domains	IPR001715	81	2	18521	50	NAV2,MACF1
2.022e-02	-3.90	Phospholipase D signaling pathway	KEGG pathways	hsa04072	145	3	7161	29	ADCY2,DGKG,PLCB1
2.022e-02	-3.90	Phospholipase D signaling pathway	KEGG pathways	ko04072	145	3	7161	29	ADCY2,PLCB1,DGKG
2.026e-02	-3.90	regulation of cellular component biogenesis	biological process	GO:0044087	1016	7	18204	50	NTRK2,NRXN1,CLU,MACF1,GPM6A,GFAP,APOE
2.032e-02	-3.90	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	49	NTRK2,ERBB4
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.038e-02	-3.89	UBALD2 (UBA like domain containing 2)	protein interactions	283991	8	1	19454	50	GFAP
2.038e-02	-3.89	NKAIN3 (sodium/potassium transporting ATPase interacting 3)	protein interactions	286183	8	1	19454	50	GFAP
2.042e-02	-3.89	negative regulation of cell migration	biological process	GO:0030336	381	4	18204	50	NRG3,PLCB1,PRKG1,APOE
2.051e-02	-3.89	Signaling by PTK6	REACTOME pathways	R-HSA-8848021	67	2	10285	34	NRG3,ERBB4
2.055e-02	-3.88	PRKCD (protein kinase C delta)	protein interactions	5580	227	3	19454	50	CAMK2G,MACF1,PLCB1
2.059e-02	-3.88	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	22	NRG3,ERBB4
2.063e-02	-3.88	FAM171A1 (family with sequence similarity 171 member A1)	protein interactions	221061	86	2	19454	50	PARD3,NTRK2
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	GPM6A,SORBS1
2.068e-02	-3.88	CH_dom_sf	interpro domains	IPR036872	82	2	18521	50	NAV2,MACF1
2.075e-02	-3.88	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	50	CLU
2.075e-02	-3.88	zonula adherens	cellular component	GO:0005915	8	1	19108	50	SORBS1
2.099e-02	-3.86	GLYPICAN	prosite domains	PS01207	6	1	12186	43	GPC5
2.099e-02	-3.86	GAR	prosite domains	PS51460	6	1	12186	43	MACF1
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	RYR3,MACF1,DGKG
2.103e-02	-3.86	VANGL1 (VANGL planar cell polarity protein 1)	protein interactions	81839	229	3	19454	50	NTRK2,PARD3,ERBB4
2.133e-02	-3.85	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	46	16828	48	PITPNC1,ATP1A2,PLCB1,TNIK,LRP1B,ERBB4,NAV2,GLIS3,NKAIN3,TNC,SLC1A2,NRXN1,NEBL,NTM,PRKG1,CAMK2G,DTNA,GPC5,RFX4,NRG3,LSAMP,CLU,RORA,MACF1,HPSE2,MGAT4C,SORBS1,GPM6A,FMN2,GFAP,RYR3,DGKG,NTRK2,CNTN1,MSI2,ADCY2,CDH20,PARD3,CTNND2,NPAS3,DCLK2,SLC14A1,SOX5,SLC4A4,ABLIM1,TRPM3
2.135e-02	-3.85	regulation of steroid biosynthetic process	biological process	GO:0050810	82	2	18204	50	APOE,PRKG1
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY2
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY2
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.146e-02	-3.84	CDC37 (cell division cycle 37, HSP90 cochaperone)	protein interactions	11140	623	5	19454	50	CAMK2G,APOE,NTRK2,DCLK2,GFAP
2.146e-02	-3.84	cyclic nucleotide-dependent protein kinase activity	molecular function	GO:0004690	8	1	18094	49	PRKG1
2.146e-02	-3.84	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	49	ATP1A2
2.146e-02	-3.84	sodium ion binding	molecular function	GO:0031402	8	1	18094	49	ATP1A2
2.146e-02	-3.84	urea transmembrane transporter activity	molecular function	GO:0015204	8	1	18094	49	SLC14A1
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	NTM,CNTN1,LSAMP,NTRK2
2.157e-02	-3.84	FYN (FYN proto-oncogene, Src family tyrosine kinase)	protein interactions	2534	414	4	19454	50	ERBB4,CTNND2,NTRK2,CNTN1
2.157e-02	-3.84	Receptor L-domain	gene3d domains	3.80.20.20	7	1	14470	45	ERBB4
2.157e-02	-3.84	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	1	14470	45	SLC1A2
2.157e-02	-3.84	Ammonium transporter AmtB like domains	gene3d domains	1.10.3430.10	7	1	14470	45	SLC14A1
2.159e-02	-3.84	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	5	19454	50	GFAP,SLC14A1,SORBS1,ERBB4,MSI2
2.161e-02	-3.83	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	45	NEBL,ABLIM1
2.172e-02	-3.83	regulation of cell junction assembly	biological process	GO:1901888	217	3	18204	50	MACF1,NRXN1,NTRK2
2.175e-02	-3.83	phosphatidylinositol-4,5-bisphosphate binding	molecular function	GO:0005546	84	2	18094	49	PARD3,PLCB1
2.175e-02	-3.83	CTSB (cathepsin B)	protein interactions	1508	232	3	19454	50	MSI2,APOE,CST3
2.175e-02	-3.83	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	6	ADCY2
2.177e-02	-3.83	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	50	RORA
2.177e-02	-3.83	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	50	FMN2
2.177e-02	-3.83	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	50	RORA
2.177e-02	-3.83	central nervous system myelin formation	biological process	GO:0032289	8	1	18204	50	CNTN1
2.177e-02	-3.83	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	50	CTNNA2
2.177e-02	-3.83	cellular response to vasopressin	biological process	GO:1904117	8	1	18204	50	PLCB1
2.177e-02	-3.83	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	50	APOE
2.177e-02	-3.83	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	50	APOE
2.177e-02	-3.83	regulation of chaperone-mediated autophagy	biological process	GO:1904714	8	1	18204	50	GFAP
2.177e-02	-3.83	ion channel modulating, G protein-coupled receptor signaling pathway	biological process	GO:0099105	8	1	18204	50	PLCB1
2.177e-02	-3.83	response to vasopressin	biological process	GO:1904116	8	1	18204	50	PLCB1
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.177e-02	-3.83	phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	biological process	GO:0007207	8	1	18204	50	PLCB1
2.177e-02	-3.83	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	50	RORA
2.177e-02	-3.83	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	50	APOE
2.177e-02	-3.83	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	50	APOE
2.182e-02	-3.82	VHP	pfam domains	PF02209	8	1	17795	49	ABLIM1
2.182e-02	-3.82	DCX	pfam domains	PF03607	8	1	17795	49	DCLK2
2.182e-02	-3.82	LSDAT_euk	pfam domains	PF18139	8	1	17795	49	TRPM3
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY2
2.184e-02	-3.82	regulation of amine transport	biological process	GO:0051952	83	2	18204	50	PRKG1,ATP1A2
2.203e-02	-3.82	SH3_domain	interpro domains	IPR001452	222	3	18521	50	SORBS1,MACF1,NEBL
2.209e-02	-3.81	positive regulation of cell communication	biological process	GO:0010647	1792	10	18204	50	MACF1,GPC5,ERBB4,SORBS1,GFAP,APOE,NTRK2,TNIK,NRXN1,PLCB1
2.216e-02	-3.81	Alzheimers Disease	WikiPathways	WP2059	148	3	5310	22	APOE,PLCB1,RYR3
2.224e-02	-3.81	regulation of synaptic plasticity	biological process	GO:0048167	219	3	18204	50	NTRK2,APOE,GFAP
2.225e-02	-3.81	positive regulation of signaling	biological process	GO:0023056	1794	10	18204	50	SORBS1,GFAP,APOE,NTRK2,TNIK,NRXN1,PLCB1,MACF1,GPC5,ERBB4
2.233e-02	-3.80	stem cell development	biological process	GO:0048864	84	2	18204	50	ERBB4,MSI2
2.233e-02	-3.80	peripheral nervous system development	biological process	GO:0007422	84	2	18204	50	NTRK2,PARD3
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	DTNA,FMN2
2.246e-02	-3.80	FGFR1OP2 (FGFR1 oncogene partner 2)	protein interactions	26127	90	2	19454	50	CAMK2G,TNIK
2.249e-02	-3.79	large_intestine-rectum	COSMIC cancer mutations	large_intestine-rectum	569	5	16828	48	ADCY2,CNTN1,PRKG1,ERBB4,FMN2
2.250e-02	-3.79	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	50	ATP1A2,NRXN1,TNC
2.258e-02	-3.79	regulation of metal ion transport	biological process	GO:0010959	393	4	18204	50	ATP1A2,NKAIN3,CNTN1,CAMK2G
2.260e-02	-3.79	bone-knee-chondrosarcoma-synovial	COSMIC cancer mutations	bone-knee-chondrosarcoma-synovial	8	1	16828	48	CNTN1
2.260e-02	-3.79	synovial	COSMIC cancer mutations	synovial	8	1	16828	48	CNTN1
2.264e-02	-3.79	GAS2	smart domains	SM00243	6	1	9717	37	MACF1
2.289e-02	-3.78	supramolecular fiber organization	biological process	GO:0097435	593	5	18204	50	CST3,SORBS1,GFAP,NEBL,FMN2
2.290e-02	-3.78	MUC4 (mucin 4, cell surface associated)	protein interactions	4585	9	1	19454	50	ERBB4
2.290e-02	-3.78	LSB3 (Lsb3p)	protein interactions	850580	9	1	19454	50	GFAP
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.290e-02	-3.78	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	50	APOE
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1)	protein interactions	55450	9	1	19454	50	CAMK2G
2.290e-02	-3.78	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	50	APOE
2.292e-02	-3.78	Neurofascin interactions	REACTOME pathways	R-HSA-447043	7	1	10285	34	CNTN1
2.292e-02	-3.78	TRIO (trio Rho guanine nucleotide exchange factor)	protein interactions	7204	91	2	19454	50	PARD3,NAV2
2.292e-02	-3.78	PTPN21 (protein tyrosine phosphatase non-receptor type 21)	protein interactions	11099	91	2	19454	50	NRG3,ERBB4
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	TNIK,SORBS1
2.294e-02	-3.77	Flecainide Action Pathway	SMPDB pathways	SMP0000331	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Practolol Action Pathway	SMPDB pathways	SMP0000669	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Metoprolol Action Pathway	SMPDB pathways	SMP0000302	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Bupranolol Action Pathway	SMPDB pathways	SMP0000670	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Acebutolol Action Pathway	SMPDB pathways	SMP0000296	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Bopindolol Action Pathway	SMPDB pathways	SMP0000657	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Nisoldipine Action Pathway	SMPDB pathways	SMP0000381	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Pindolol Action Pathway	SMPDB pathways	SMP0000306	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Arbutamine Action Pathway	SMPDB pathways	SMP0000664	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Timolol Action Pathway	SMPDB pathways	SMP0000659	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Metipranolol Action Pathway	SMPDB pathways	SMP0000667	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Nebivolol Action Pathway	SMPDB pathways	SMP0000366	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Nadolol Action Pathway	SMPDB pathways	SMP0000303	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Fosphenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000326	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Bevantolol Action Pathway	SMPDB pathways	SMP0000668	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Sotalol Action Pathway	SMPDB pathways	SMP0000660	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Amiodarone Action Pathway	SMPDB pathways	SMP0000665	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Carteolol Action Pathway	SMPDB pathways	SMP0000658	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Quinidine Action Pathway	SMPDB pathways	SMP0000323	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Ibutilide Action Pathway	SMPDB pathways	SMP0000332	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Esmolol Action Pathway	SMPDB pathways	SMP0000301	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Nitrendipine Action Pathway	SMPDB pathways	SMP0000382	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Amlodipine Action Pathway	SMPDB pathways	SMP0000376	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Felodipine Action Pathway	SMPDB pathways	SMP0000377	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Atenolol Action Pathway	SMPDB pathways	SMP0000298	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Penbutolol Action Pathway	SMPDB pathways	SMP0000305	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Mexiletine Action Pathway	SMPDB pathways	SMP0000329	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Muscle/Heart Contraction	SMPDB pathways	SMP0000588	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Bisoprolol Action Pathway	SMPDB pathways	SMP0000300	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Procainamide (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000324	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Epinephrine Action Pathway	SMPDB pathways	SMP0000661	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Nifedipine Action Pathway	SMPDB pathways	SMP0000379	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Levobunolol Action Pathway	SMPDB pathways	SMP0000666	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Betaxolol Action Pathway	SMPDB pathways	SMP0000299	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Diltiazem Action Pathway	SMPDB pathways	SMP0000359	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Disopyramide Action Pathway	SMPDB pathways	SMP0000325	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Dobutamine Action Pathway	SMPDB pathways	SMP0000662	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Propranolol Action Pathway	SMPDB pathways	SMP0000307	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Isoprenaline Action Pathway	SMPDB pathways	SMP0000663	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Verapamil Action Pathway	SMPDB pathways	SMP0000375	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Nimodipine Action Pathway	SMPDB pathways	SMP0000380	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Alprenolol Action Pathway	SMPDB pathways	SMP0000297	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Isradipine Action Pathway	SMPDB pathways	SMP0000378	57	2	1369	6	PLCB1,ATP1A2
2.294e-02	-3.77	Oxprenolol Action Pathway	SMPDB pathways	SMP0000304	57	2	1369	6	ATP1A2,PLCB1
2.294e-02	-3.77	Tocainide Action Pathway	SMPDB pathways	SMP0000330	57	2	1369	6	PLCB1,ATP1A2
2.315e-02	-3.77	negative regulation of cell motility	biological process	GO:2000146	396	4	18204	50	NRG3,PLCB1,PRKG1,APOE
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	CLU,LRP1B,MACF1
2.326e-02	-3.76	EGF_1	prosite domains	PS00022	174	3	12186	43	LRP1B,NRG3,TNC
2.331e-02	-3.76	astrocyte end-foot	cellular component	GO:0097450	9	1	19108	50	GFAP
2.331e-02	-3.76	flotillin complex	cellular component	GO:0016600	9	1	19108	50	SORBS1
2.334e-02	-3.76	central nervous system neuron development	biological process	GO:0021954	86	2	18204	50	DCLK2,NTRK2
2.334e-02	-3.76	protein localization to cell junction	biological process	GO:1902414	86	2	18204	50	ERBB4,NRXN1
2.336e-02	-3.76	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	22	ADCY2,RYR3,CAMK2G
2.341e-02	-3.75	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	4	16828	48	ERBB4,NTRK2,TNIK,CAMK2G
2.341e-02	-3.75	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	4	16828	48	TNIK,NTRK2,ERBB4,CAMK2G
2.341e-02	-3.75	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	4	16828	48	CAMK2G,ERBB4,NTRK2,TNIK
2.341e-02	-3.75	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	4	16828	48	CAMK2G,ERBB4,TNIK,NTRK2
2.341e-02	-3.75	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	4	16828	48	TNIK,NTRK2,ERBB4,CAMK2G
2.342e-02	-3.75	establishment of protein localization	biological process	GO:0045184	1291	8	18204	50	GFAP,APOE,CLU,FMN2,PARD3,CAMK2G,MACF1,LRP1B
2.346e-02	-3.75	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	7	18204	50	SORBS1,RORA,PLCB1,SLC1A2,RYR3,ADCY2,TNC
2.346e-02	-3.75	response to oxygen-containing compound	biological process	GO:1901700	1546	9	18204	50	ADCY2,RYR3,TNC,APOE,ATP1A2,RORA,SORBS1,SLC1A2,PLCB1
2.367e-02	-3.74	regulation of signaling	biological process	GO:0023051	3534	16	18204	50	ERBB4,GPC5,PLCB1,TNIK,DGKG,NTRK2,APOE,CTNND2,MACF1,NRG3,NRXN1,ATP1A2,RORA,GFAP,CLU,SORBS1
2.371e-02	-3.74	Labetalol Action Pathway	SMPDB pathways	SMP0000368	58	2	1369	6	PLCB1,ATP1A2
2.371e-02	-3.74	Carvedilol Action Pathway	SMPDB pathways	SMP0000367	58	2	1369	6	PLCB1,ATP1A2
2.387e-02	-3.74	EDTRNSPORT	prints domains	PR00173	7	1	5227	18	SLC1A2
2.401e-02	-3.73	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	50	PARD3,NTRK2,CTNND2
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	Doublecortin_dom	interpro domains	IPR003533	9	1	18521	50	DCLK2
2.404e-02	-3.73	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	50	CST3
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.408e-02	-3.73	regulation of cell communication	biological process	GO:0010646	3541	16	18204	50	APOE,PLCB1,DGKG,TNIK,NTRK2,GPC5,ERBB4,GFAP,ATP1A2,RORA,CLU,SORBS1,NRG3,NRXN1,MACF1,CTNND2
2.410e-02	-3.73	regulation of cell growth	biological process	GO:0001558	401	4	18204	50	MACF1,APOE,TNC,NRG3
2.420e-02	-3.72	ACTG1 (actin gamma 1)	protein interactions	71	429	4	19454	50	FMN2,TNIK,APOE,ABLIM1
2.424e-02	-3.72	Long-term depression	KEGG pathways	hsa04730	60	2	7161	29	PRKG1,PLCB1
2.424e-02	-3.72	Long-term depression	KEGG pathways	ko04730	60	2	7161	29	PRKG1,PLCB1
2.426e-02	-3.72	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	45	16828	48	CLU,LSAMP,RORA,MACF1,HPSE2,NRG3,PRKG1,DTNA,CAMK2G,GPC5,NEBL,TNC,APOE,NKAIN3,SLC1A2,NRXN1,ERBB4,NAV2,GLIS3,TNIK,PLCB1,LRP1B,PITPNC1,ATP1A2,SLC4A4,SOX5,ABLIM1,TRPM3,DCLK2,SLC14A1,PARD3,CTNND2,NPAS3,ADCY2,CDH20,NTRK2,CNTN1,MSI2,DGKG,FMN2,GPM6A,SORBS1,GFAP,RYR3,MGAT4C
2.426e-02	-3.72	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	45	16828	48	LSAMP,CLU,RORA,MACF1,HPSE2,NRG3,PRKG1,DTNA,CAMK2G,GPC5,NEBL,APOE,NKAIN3,TNC,SLC1A2,NRXN1,ERBB4,NAV2,GLIS3,PLCB1,TNIK,LRP1B,PITPNC1,ATP1A2,SOX5,SLC4A4,ABLIM1,TRPM3,DCLK2,SLC14A1,PARD3,CTNND2,NPAS3,ADCY2,CDH20,NTRK2,CNTN1,MSI2,DGKG,GPM6A,FMN2,SORBS1,GFAP,RYR3,MGAT4C
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CLU,CTNND2
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	ABLIM1,TNIK
2.435e-02	-3.72	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	50	CAMK2G,NTRK2
2.445e-02	-3.71	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	1	12186	43	SLC1A2
2.445e-02	-3.71	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	1	12186	43	SLC1A2
2.446e-02	-3.71	sterol catabolic process	biological process	GO:0016127	9	1	18204	50	APOE
2.446e-02	-3.71	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	50	CTNNA2
2.446e-02	-3.71	positive regulation of synapse maturation	biological process	GO:0090129	9	1	18204	50	NRXN1
2.446e-02	-3.71	negative regulation of cellular extravasation	biological process	GO:0002692	9	1	18204	50	PLCB1
2.446e-02	-3.71	macrophage proliferation	biological process	GO:0061517	9	1	18204	50	CLU
2.446e-02	-3.71	microglial cell proliferation	biological process	GO:0061518	9	1	18204	50	CLU
2.446e-02	-3.71	mesenchymal-epithelial cell signaling	biological process	GO:0060638	9	1	18204	50	TNC
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.446e-02	-3.71	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	50	CTNNA2
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.446e-02	-3.71	interleukin-12-mediated signaling pathway	biological process	GO:0035722	9	1	18204	50	PLCB1
2.446e-02	-3.71	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	50	APOE
2.449e-02	-3.71	lower_third	COSMIC cancer mutations	lower_third	7961	30	16828	48	RYR3,LRP1B,SORBS1,PLCB1,FMN2,ATP1A2,MGAT4C,NRXN1,CNTN1,NTRK2,TNC,NAV2,ERBB4,DGKG,GPC5,CTNND2,NPAS3,PRKG1,PARD3,CDH20,ADCY2,NEBL,HPSE2,MACF1,TRPM3,RORA,SOX5,SLC4A4,NRG3,DCLK2
2.450e-02	-3.71	Lidocaine (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000328	59	2	1369	6	PLCB1,ATP1A2
2.450e-02	-3.71	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	48	LRP1B,PLCB1,FMN2,ERBB4,SLC4A4
2.452e-02	-3.71	Band_3_cyto	pfam domains	PF07565	9	1	17795	49	SLC4A4
2.452e-02	-3.71	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	49	RFX4
2.462e-02	-3.70	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	45	ABLIM1
2.464e-02	-3.70	nucleotide binding	molecular function	GO:0000166	2128	11	18094	49	MAPK10,NAV2,NTRK2,DGKG,DCLK2,ERBB4,TNIK,ADCY2,CAMK2G,PRKG1,ATP1A2
2.472e-02	-3.70	nucleoside phosphate binding	molecular function	GO:1901265	2129	11	18094	49	TNIK,CAMK2G,ADCY2,PRKG1,ATP1A2,NAV2,MAPK10,DGKG,NTRK2,DCLK2,ERBB4
2.479e-02	-3.70	DDX31 (DEAD-box helicase 31)	protein interactions	64794	244	3	19454	50	CLU,PRKG1,CST3
2.483e-02	-3.70	STRIP1 (striatin interacting protein 1)	protein interactions	85369	95	2	19454	50	CAMK2G,TNIK
2.487e-02	-3.69	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	2	18204	50	APOE,SORBS1
2.504e-02	-3.69	Calponin-like domain	gene3d domains	1.10.418.10	79	2	14470	45	NAV2,MACF1
2.514e-02	-3.68	intermediate filament cytoskeleton	cellular component	GO:0045111	241	3	19108	50	GFAP,MACF1,DTNA
2.532e-02	-3.68	SOCS2 (suppressor of cytokine signaling 2)	protein interactions	8835	96	2	19454	50	NTRK2,ERBB4
2.541e-02	-3.67	DOA4 (ubiquitin-specific protease DOA4)	protein interactions	851641	10	1	19454	50	NAV2
2.541e-02	-3.67	ZNF563 (zinc finger protein 563)	protein interactions	147837	10	1	19454	50	LRP1B
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	EREG (epiregulin)	protein interactions	2069	10	1	19454	50	ERBB4
2.541e-02	-3.67	PTPRT (protein tyrosine phosphatase receptor type T)	protein interactions	11122	10	1	19454	50	ERBB4
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	CHRDL1 (chordin like 1)	protein interactions	91851	10	1	19454	50	LRP1B
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.546e-02	-3.67	regulation of biological process	biological process	GO:0050789	12079	40	18204	50	DTNA,NPAS3,PLCB1,PITPNC1,NTRK2,GLIS3,SLC4A4,CNTN1,ADCY2,NRG3,MAPK10,RORA,ATP1A2,SORBS1,CST3,HPSE2,SOX5,PARD3,CAMK2G,DCLK2,CTNNA2,PRKG1,GPM6A,CTNND2,MACF1,SLC1A2,TNIK,DGKG,RFX4,APOE,TNC,ERBB4,GPC5,NRXN1,GFAP,NKAIN3,CLU,FMN2,MSI2,RYR3
2.579e-02	-3.66	biological regulation	biological process	GO:0065007	12501	41	18204	50	ADCY2,CNTN1,SLC4A4,GLIS3,PITPNC1,NTRK2,DTNA,PLCB1,NPAS3,CTNND2,GPM6A,MACF1,PRKG1,CTNNA2,CAMK2G,DCLK2,SOX5,HPSE2,PARD3,NAV2,SORBS1,CST3,RORA,ATP1A2,NRG3,MAPK10,ERBB4,GPC5,TNC,APOE,RFX4,DGKG,TNIK,SLC1A2,MSI2,RYR3,FMN2,NKAIN3,CLU,GFAP,NRXN1
2.581e-02	-3.66	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	2	19454	50	CLU,DCLK2
2.585e-02	-3.66	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	3	19454	50	TNIK,SOX5,DGKG
2.585e-02	-3.66	ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)	protein interactions	25	248	3	19454	50	SORBS1,ERBB4,CTNND2
2.592e-02	-3.65	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	43	ABLIM1,NEBL
2.592e-02	-3.65	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	43	NEBL,ABLIM1
2.598e-02	-3.65	CH	smart domains	SM00033	66	2	9717	37	NAV2,MACF1
2.606e-02	-3.65	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	6	ADCY2
2.606e-02	-3.65	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	6	ADCY2
2.606e-02	-3.65	Phospholipase C Signaling Pathway	SMPDB pathways	SMP0063783	6	1	1369	6	PLCB1
2.612e-02	-3.65	GAN (gigaxonin)	protein interactions	8139	249	3	19454	50	GFAP,CTNNA2,PLCB1
2.615e-02	-3.64	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	34	GPC5
2.615e-02	-3.64	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME pathways	R-HSA-434316	8	1	10285	34	PLCB1
2.615e-02	-3.64	Free fatty acids regulate insulin secretion	REACTOME pathways	R-HSA-400451	8	1	10285	34	PLCB1
2.615e-02	-3.64	Downregulation of ERBB4 signaling	REACTOME pathways	R-HSA-1253288	8	1	10285	34	ERBB4
2.617e-02	-3.64	sarcoplasm	cellular component	GO:0016528	96	2	19108	50	RYR3,CAMK2G
2.629e-02	-3.64	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	3	5310	22	ADCY2,RYR3,CAMK2G
2.631e-02	-3.64	FRAS1 (Fraser extracellular matrix complex subunit 1)	protein interactions	80144	98	2	19454	50	HPSE2,MGAT4C
2.636e-02	-3.64	PLEC	smart domains	SM00250	7	1	9717	37	MACF1
2.644e-02	-3.63	actin filament-based process	biological process	GO:0030029	616	5	18204	50	SORBS1,PRKG1,NEBL,TNIK,FMN2
2.645e-02	-3.63	protein tetramerization	biological process	GO:0051262	92	2	18204	50	TRPM3,RYR3
2.646e-02	-3.63	human chr2p16.3	chromosome location	human chr2p16.3	14	1	26134	50	NRXN1
2.646e-02	-3.63	human chr9q33.1	chromosome location	human chr9q33.1	14	1	26134	50	TNC
2.648e-02	-3.63	ankle	COSMIC cancer mutations	ankle	398	4	16828	48	PLCB1,ERBB4,PARD3,NRG3
2.649e-02	-3.63	negative regulation of locomotion	biological process	GO:0040013	413	4	18204	50	APOE,PRKG1,PLCB1,NRG3
2.667e-02	-3.62	Endothelins	Pathway Interaction DB	endothelinpathway	53	2	2226	11	ADCY2,PLCB1
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	Doublecortin_dom_sf	interpro domains	IPR036572	10	1	18521	50	DCLK2
2.668e-02	-3.62	Diacylglycerol_kin_accessory	interpro domains	IPR000756	10	1	18521	50	DGKG
2.668e-02	-3.62	DGK	interpro domains	IPR037607	10	1	18521	50	DGKG
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.676e-02	-3.62	neurotrophin binding	molecular function	GO:0043121	10	1	18094	49	NTRK2
2.676e-02	-3.62	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	49	PITPNC1
2.678e-02	-3.62	YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon)	protein interactions	7531	1150	7	19454	50	NAV2,CAMK2G,ABLIM1,DCLK2,MACF1,SORBS1,PARD3
2.680e-02	-3.62	TPP1 (tripeptidyl peptidase 1)	protein interactions	1200	99	2	19454	50	DGKG,APOE
2.690e-02	-3.62	anterograde trans-synaptic signaling	biological process	GO:0098916	415	4	18204	50	SLC1A2,DTNA,NRXN1,APOE
2.690e-02	-3.62	chemical synaptic transmission	biological process	GO:0007268	415	4	18204	50	APOE,SLC1A2,DTNA,NRXN1
2.699e-02	-3.61	intermediate filament cytoskeleton organization	biological process	GO:0045104	93	2	18204	50	MACF1,GFAP
2.699e-02	-3.61	regulation of extent of cell growth	biological process	GO:0061387	93	2	18204	50	APOE,MACF1
2.714e-02	-3.61	postsynaptic density assembly	biological process	GO:0097107	10	1	18204	50	NRXN1
2.714e-02	-3.61	cellular response to cocaine	biological process	GO:0071314	10	1	18204	50	SLC1A2
2.714e-02	-3.61	establishment of centrosome localization	biological process	GO:0051660	10	1	18204	50	PARD3
2.714e-02	-3.61	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	50	NRG3
2.714e-02	-3.61	postsynaptic membrane assembly	biological process	GO:0097104	10	1	18204	50	NRXN1
2.714e-02	-3.61	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	50	APOE
2.714e-02	-3.61	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	50	APOE
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	50	APOE
2.714e-02	-3.61	urea transmembrane transport	biological process	GO:0071918	10	1	18204	50	SLC14A1
2.714e-02	-3.61	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	50	NRG3
2.714e-02	-3.61	mitochondrial fragmentation involved in apoptotic process	biological process	GO:0043653	10	1	18204	50	ERBB4
2.714e-02	-3.61	retinal rod cell development	biological process	GO:0046548	10	1	18204	50	NTRK2
2.714e-02	-3.61	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	50	ADCY2
2.714e-02	-3.61	learned vocalization behavior or vocal learning	biological process	GO:0098598	10	1	18204	50	NRXN1
2.714e-02	-3.61	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	50	APOE
2.714e-02	-3.61	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	50	NTRK2
2.714e-02	-3.61	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	50	APOE
2.714e-02	-3.61	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	50	NTRK2
2.714e-02	-3.61	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	50	APOE
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	NTRK2,ERBB4
2.719e-02	-3.60	EGF-type_Asp/Asn_hydroxyl_site	interpro domains	IPR000152	95	2	18521	50	LRP1B,NRXN1
2.720e-02	-3.60	HCO3_cotransp	pfam domains	PF00955	10	1	17795	49	SLC4A4
2.720e-02	-3.60	DAGK_acc	pfam domains	PF00609	10	1	17795	49	DGKG
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	RYR3
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	GPM6A,ATP1A2
2.731e-02	-3.60	APBA1 (amyloid beta precursor protein binding family A member 1)	protein interactions	320	100	2	19454	50	ABLIM1,NRXN1
2.731e-02	-3.60	EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2)	protein interactions	55741	100	2	19454	50	CLU,HPSE2
2.733e-02	-3.60	positive regulation of transport	biological process	GO:0051050	844	6	18204	50	APOE,CLU,SORBS1,SLC1A2,PLCB1,CNTN1
2.752e-02	-3.59	intermediate filament-based process	biological process	GO:0045103	94	2	18204	50	MACF1,GFAP
2.753e-02	-3.59	blood circulation	biological process	GO:0008015	418	4	18204	50	NAV2,PRKG1,APOE,ATP1A2
2.756e-02	-3.59	muscle contraction	biological process	GO:0006936	238	3	18204	50	DTNA,ATP1A2,RYR3
2.756e-02	-3.59	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	50	ERBB4,TNIK,MACF1
2.765e-02	-3.59	Doublecortin domain	gene3d domains	3.10.20.230	9	1	14470	45	DCLK2
2.776e-02	-3.58	LMO2 (LIM domain only 2)	protein interactions	4005	255	3	19454	50	SOX5,GFAP,PRKG1
2.777e-02	-3.58	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	91	2	16828	48	LRP1B,ADCY2
2.781e-02	-3.58	PRKCG (protein kinase C gamma)	protein interactions	5582	101	2	19454	50	PARD3,GFAP
2.785e-02	-3.58	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	4	10285	34	CAMK2G,ADCY2,NRG3,ERBB4
2.786e-02	-3.58	positive regulation of signal transduction	biological process	GO:0009967	1593	9	18204	50	ERBB4,GPC5,MACF1,PLCB1,NRXN1,NTRK2,TNIK,APOE,SORBS1
2.789e-02	-3.58	HP	prosite domains	PS51089	8	1	12186	43	ABLIM1
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	SYTL1 (synaptotagmin like 1)	protein interactions	84958	11	1	19454	50	NRXN1
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	SCN3A (sodium voltage-gated channel alpha subunit 3)	protein interactions	6328	11	1	19454	50	CNTN1
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	PRKG1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	1	19454	50	ADCY2
2.796e-02	-3.58	protein transport	biological process	GO:0015031	1086	7	18204	50	FMN2,CAMK2G,MACF1,LRP1B,APOE,GFAP,CLU
2.807e-02	-3.57	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	50	PLCB1,RYR3
2.807e-02	-3.57	cardiac muscle cell differentiation	biological process	GO:0055007	95	2	18204	50	NEBL,PRKG1
2.809e-02	-3.57	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	50	ERBB4,NTRK2,NRG3,PLCB1,SORBS1
2.831e-02	-3.56	Alzheimer's disease	KEGG pathways	hsa05010	165	3	7161	29	PLCB1,RYR3,APOE
2.831e-02	-3.56	Alzheimer's disease	KEGG pathways	ko05010	165	3	7161	29	PLCB1,APOE,RYR3
2.832e-02	-3.56	PDLIM7 (PDZ and LIM domain 7)	protein interactions	9260	257	3	19454	50	ABLIM1,PARD3,GFAP
2.832e-02	-3.56	human chr18q12.3	chromosome location	human chr18q12.3	15	1	26134	50	SLC14A1
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.832e-02	-3.56	GRAP2 (GRB2 related adaptor protein 2)	protein interactions	9402	102	2	19454	50	GFAP,ERBB4
2.832e-02	-3.56	KRTAP6-1 (keratin associated protein 6-1)	protein interactions	337966	102	2	19454	50	CAMK2G,GLIS3
2.842e-02	-3.56	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	50	TNC
2.862e-02	-3.55	negative regulation of response to wounding	biological process	GO:1903035	96	2	18204	50	APOE,PRKG1
2.863e-02	-3.55	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	10	16828	48	HPSE2,TRPM3,CNTN1,NTRK2,FMN2,SOX5,SLC1A2,RFX4,NRG3,DGKG
2.863e-02	-3.55	functioning	COSMIC cancer mutations	functioning	1803	10	16828	48	NRG3,RFX4,DGKG,TRPM3,HPSE2,CNTN1,SOX5,SLC1A2,NTRK2,FMN2
2.869e-02	-3.55	cell surface	cellular component	GO:0009986	896	6	19108	50	GPC5,NRXN1,ATP1A2,SLC4A4,SLC1A2,CLU
2.881e-02	-3.55	developmental growth	biological process	GO:0048589	424	4	18204	50	PRKG1,ERBB4,TNC,SLC1A2
2.881e-02	-3.55	growth	biological process	GO:0040007	424	4	18204	50	TNC,SLC1A2,ERBB4,PRKG1
2.884e-02	-3.55	ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)	protein interactions	25921	103	2	19454	50	NTRK2,PARD3
2.888e-02	-3.54	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	4	10285	34	CAMK2G,NRG3,ERBB4,ADCY2
2.891e-02	-3.54	aldosterone_producing	COSMIC cancer mutations	aldosterone_producing	93	2	16828	48	LRP1B,ADCY2
2.891e-02	-3.54	transmembrane transporter activity	molecular function	GO:0022857	1110	7	18094	49	RYR3,SLC4A4,TRPM3,SLC1A2,GPM6A,ATP1A2,SLC14A1
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	LSAMP,NTRK2,NTM,CNTN1
2.917e-02	-3.53	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	50	SLC1A2,GFAP
2.917e-02	-3.53	positive regulation of JNK cascade	biological process	GO:0046330	97	2	18204	50	TNIK,PLCB1
2.917e-02	-3.53	acylglycerol metabolic process	biological process	GO:0006639	97	2	18204	50	DGKG,APOE
2.929e-02	-3.53	EF-hand_7	pfam domains	PF13499	97	2	17795	49	DGKG,MACF1
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.937e-02	-3.53	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	34	CLU
2.940e-02	-3.53	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	2	12186	43	APOE,GLIS3
2.940e-02	-3.53	acetylcholine receptor binding	molecular function	GO:0033130	11	1	18094	49	NRXN1
2.940e-02	-3.53	ATP-dependent diacylglycerol kinase activity	molecular function	GO:0004143	11	1	18094	49	DGKG
2.940e-02	-3.53	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	49	SLC1A2
2.964e-02	-3.52	basolateral plasma membrane	cellular component	GO:0016323	257	3	19108	50	ERBB4,SLC4A4,SLC14A1
2.968e-02	-3.52	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	4	18204	50	RYR3,APOE,ATP1A2,SLC4A4
2.968e-02	-3.52	negative regulation of response to external stimulus	biological process	GO:0032102	428	4	18204	50	RORA,APOE,PRKG1,CTNNA2
2.971e-02	-3.52	response to abiotic stimulus	biological process	GO:0009628	1100	7	18204	50	FMN2,TNC,RORA,ATP1A2,NRXN1,SLC1A2,MAPK10
2.972e-02	-3.52	neutral lipid metabolic process	biological process	GO:0006638	98	2	18204	50	APOE,DGKG
2.974e-02	-3.52	LIM	smart domains	SM00132	71	2	9717	37	NEBL,ABLIM1
2.976e-02	-3.51	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	29	PLCB1,CAMK2G
2.976e-02	-3.51	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	29	PLCB1,CAMK2G
2.981e-02	-3.51	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	50	NRG3
2.981e-02	-3.51	L-aspartate transmembrane transport	biological process	GO:0070778	11	1	18204	50	SLC1A2
2.981e-02	-3.51	regulation of Schwann cell proliferation	biological process	GO:0010624	11	1	18204	50	GFAP
2.981e-02	-3.51	physiological cardiac muscle hypertrophy	biological process	GO:0003301	11	1	18204	50	PRKG1
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	lipid phosphorylation	biological process	GO:0046834	11	1	18204	50	DGKG
2.981e-02	-3.51	ectodermal placode formation	biological process	GO:0060788	11	1	18204	50	NRG3
2.981e-02	-3.51	cellular response to interleukin-12	biological process	GO:0071349	11	1	18204	50	PLCB1
2.981e-02	-3.51	glutamate secretion	biological process	GO:0014047	11	1	18204	50	NTRK2
2.981e-02	-3.51	positive regulation of acrosome reaction	biological process	GO:2000344	11	1	18204	50	PLCB1
2.981e-02	-3.51	cell growth involved in cardiac muscle cell development	biological process	GO:0061049	11	1	18204	50	PRKG1
2.981e-02	-3.51	L-glutamate import across plasma membrane	biological process	GO:0098712	11	1	18204	50	SLC1A2
2.981e-02	-3.51	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	50	NRG3
2.981e-02	-3.51	regulation of fear response	biological process	GO:1903365	11	1	18204	50	APOE
2.981e-02	-3.51	interleukin-15-mediated signaling pathway	biological process	GO:0035723	11	1	18204	50	PLCB1
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	50	PRKG1
2.981e-02	-3.51	cellular response to interleukin-15	biological process	GO:0071350	11	1	18204	50	PLCB1
2.981e-02	-3.51	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	50	APOE
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.981e-02	-3.51	Bergmann glial cell differentiation	biological process	GO:0060020	11	1	18204	50	GFAP
2.981e-02	-3.51	physiological muscle hypertrophy	biological process	GO:0003298	11	1	18204	50	PRKG1
2.981e-02	-3.51	pyramidal neuron development	biological process	GO:0021860	11	1	18204	50	DCLK2
2.981e-02	-3.51	egg activation	biological process	GO:0007343	11	1	18204	50	PLCB1
2.981e-02	-3.51	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	50	APOE
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.999e-02	-3.51	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	50	MACF1,GFAP,NTRK2
3.007e-02	-3.50	VHP	smart domains	SM00153	8	1	9717	37	ABLIM1
3.028e-02	-3.50	phospholipid transport	biological process	GO:0015914	99	2	18204	50	PITPNC1,APOE
3.028e-02	-3.50	regulation of neurotransmitter transport	biological process	GO:0051588	99	2	18204	50	ATP1A2,GFAP
3.034e-02	-3.50	response to wounding	biological process	GO:0009611	431	4	18204	50	DGKG,TNC,SLC1A2,MACF1
3.034e-02	-3.50	G-Protein Signaling Through Tubby Proteins	SMPDB pathways	SMP0089843	7	1	1369	6	PLCB1
3.034e-02	-3.50	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	6	ADCY2
3.034e-02	-3.50	g-Secretase Mediated ErbB4 Signalling Pathway	SMPDB pathways	SMP0089975	7	1	1369	6	ERBB4
3.036e-02	-3.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	5	19454	50	FMN2,PLCB1,TNIK,MACF1,NAV2
3.040e-02	-3.49	USP6NL (USP6 N-terminal like)	protein interactions	9712	106	2	19454	50	NTRK2,PARD3
3.042e-02	-3.49	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	50	ERBB4
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	INTS4P2 (integrator complex subunit 4 pseudogene 2)	protein interactions	644619	12	1	19454	50	GFAP
3.042e-02	-3.49	SMIM20 (small integral membrane protein 20)	protein interactions	389203	12	1	19454	50	ERBB4
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	OAS2 (2'-5'-oligoadenylate synthetase 2)	protein interactions	4939	12	1	19454	50	PRKG1
3.042e-02	-3.49	Pard6b (par-6 family cell polarity regulator beta)	protein interactions	58220	12	1	19454	50	PARD3
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	KIF26A (kinesin family member 26A)	protein interactions	26153	12	1	19454	50	MAPK10
3.042e-02	-3.49	PROK2 (prokineticin 2)	protein interactions	60675	12	1	19454	50	LRP1B
3.042e-02	-3.49	MYBPHL (myosin binding protein H like)	protein interactions	343263	12	1	19454	50	GFAP
3.058e-02	-3.49	CTNNB1 (catenin beta 1)	protein interactions	1499	926	6	19454	50	PARD3,CTNNA2,SORBS1,APOE,DTNA,CTNND2
3.059e-02	-3.49	NAKATPASE	prints domains	PR00121	9	1	5227	18	ATP1A2
3.068e-02	-3.48	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	45	SLC4A4
3.085e-02	-3.48	regulation of dendrite development	biological process	GO:0050773	100	2	18204	50	DGKG,TNIK
3.085e-02	-3.48	response to alkaloid	biological process	GO:0043279	100	2	18204	50	SLC1A2,RYR3
3.093e-02	-3.48	regulation of muscle system process	biological process	GO:0090257	249	3	18204	50	ATP1A2,PRKG1,CAMK2G
3.096e-02	-3.48	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	50	TNC
3.096e-02	-3.48	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	50	ATP1A2
3.097e-02	-3.47	HSPA5 (heat shock protein family A (Hsp70) member 5)	protein interactions	3309	1455	8	19454	50	CLU,GPC5,HPSE2,DTNA,APOE,GFAP,LRP1B,PARD3
3.099e-02	-3.47	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	4	10285	34	CAMK2G,NRG3,ERBB4,ADCY2
3.107e-02	-3.47	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	4	19454	50	CTNNA2,TNIK,CNTN1,PLCB1
3.132e-02	-3.46	RFX_DBD	prosite domains	PS51526	9	1	12186	43	RFX4
3.132e-02	-3.46	DC	prosite domains	PS50309	9	1	12186	43	DCLK2
3.132e-02	-3.46	CYSTATIN	prosite domains	PS00287	9	1	12186	43	CST3
3.137e-02	-3.46	amide binding	molecular function	GO:0033218	254	3	18094	49	CST3,CLU,APOE
3.139e-02	-3.46	regulation of protein localization	biological process	GO:0032880	872	6	18204	50	APOE,SORBS1,PLCB1,ERBB4,GPC5,DCLK2
3.142e-02	-3.46	cholesterol homeostasis	biological process	GO:0042632	101	2	18204	50	APOE,RORA
3.142e-02	-3.46	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	50	SORBS1,RORA
3.142e-02	-3.46	regulation of carbohydrate biosynthetic process	biological process	GO:0043255	101	2	18204	50	SORBS1,PRKG1
3.147e-02	-3.46	CLASP1 (cytoplasmic linker associated protein 1)	protein interactions	23332	108	2	19454	50	MACF1,DCLK2
3.147e-02	-3.46	ALDH3B1 (aldehyde dehydrogenase 3 family member B1)	protein interactions	221	108	2	19454	50	GFAP,FMN2
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	GPM6A,CLU
3.149e-02	-3.46	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	50	MACF1,FMN2,ABLIM1,CAMK2G
3.151e-02	-3.46	VCL (vinculin)	protein interactions	7414	268	3	19454	50	NEBL,MACF1,SORBS1
3.165e-02	-3.45	Human Thyroid Stimulating Hormone (TSH) signaling pathway	WikiPathways	WP2032	68	2	5310	22	PLCB1,ADCY2
3.169e-02	-3.45	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	4	18204	50	SLC4A4,RYR3,ATP1A2,APOE
3.189e-02	-3.45	SH3 Domains	gene3d domains	2.30.30.40	223	3	14470	45	MACF1,NEBL,SORBS1
3.192e-02	-3.44	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	2	10285	34	ADCY2,PLCB1
3.193e-02	-3.44	MAP_kinase_CS	interpro domains	IPR003527	12	1	18521	50	MAPK10
3.193e-02	-3.44	PLC_EF-hand-like	interpro domains	IPR015359	12	1	18521	50	PLCB1
3.199e-02	-3.44	sterol homeostasis	biological process	GO:0055092	102	2	18204	50	APOE,RORA
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	SOX5,TRPM3
3.200e-02	-3.44	SIPA1L3 (signal induced proliferation associated 1 like 3)	protein interactions	23094	109	2	19454	50	PARD3,GFAP
3.203e-02	-3.44	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	49	ADCY2
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.233e-02	-3.43	SH3DOMAIN	prints domains	PR00452	83	2	5227	18	SORBS1,NEBL
3.240e-02	-3.43	EGF	smart domains	SM00181	184	3	9717	37	LRP1B,TNC,NRXN1
3.243e-02	-3.43	Axon guidance	KEGG pathways	ko04360	174	3	7161	29	CAMK2G,PARD3,ABLIM1
3.243e-02	-3.43	Axon guidance	KEGG pathways	hsa04360	174	3	7161	29	ABLIM1,PARD3,CAMK2G
3.246e-02	-3.43	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	45	16828	48	TNC,SLC1A2,NRXN1,NAV2,ERBB4,GLIS3,PLCB1,TNIK,LRP1B,PITPNC1,ATP1A2,CLU,LSAMP,RORA,HPSE2,MACF1,NRG3,RFX4,NTM,PRKG1,CAMK2G,DTNA,GPC5,NEBL,NTRK2,CNTN1,MSI2,DGKG,GPM6A,FMN2,SORBS1,GFAP,RYR3,MGAT4C,SLC4A4,SOX5,ABLIM1,TRPM3,DCLK2,SLC14A1,PARD3,CTNND2,NPAS3,ADCY2,CDH20
3.248e-02	-3.43	auditory behavior	biological process	GO:0031223	12	1	18204	50	NRXN1
3.248e-02	-3.43	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	50	APOE
3.248e-02	-3.43	urea transport	biological process	GO:0015840	12	1	18204	50	SLC14A1
3.248e-02	-3.43	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	50	SLC1A2
3.248e-02	-3.43	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	50	CST3
3.248e-02	-3.43	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	50	CST3
3.248e-02	-3.43	response to interleukin-15	biological process	GO:0070672	12	1	18204	50	PLCB1
3.248e-02	-3.43	negative regulation of smooth muscle contraction	biological process	GO:0045986	12	1	18204	50	PRKG1
3.248e-02	-3.43	response to interleukin-12	biological process	GO:0070671	12	1	18204	50	PLCB1
3.256e-02	-3.42	EF-hand_like	pfam domains	PF09279	12	1	17795	49	PLCB1
3.258e-02	-3.42	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	34	ADCY2
3.258e-02	-3.42	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	34	SLC4A4
3.258e-02	-3.42	Activation of the AP-1 family of transcription factors	REACTOME pathways	R-HSA-450341	10	1	10285	34	MAPK10
3.258e-02	-3.42	Acetylcholine regulates insulin secretion	REACTOME pathways	R-HSA-399997	10	1	10285	34	PLCB1
3.263e-02	-3.42	peptide binding	molecular function	GO:0042277	258	3	18094	49	APOE,CLU,CST3
3.270e-02	-3.42	nervous system process	biological process	GO:0050877	1376	8	18204	50	ATP1A2,APOE,NAV2,ABLIM1,PLCB1,NRXN1,NTRK2,CTNNA2
3.272e-02	-3.42	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	48	TNIK,NTRK2,PRKG1,CAMK2G,ERBB4,DCLK2
3.272e-02	-3.42	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	48	DCLK2,ERBB4,PRKG1,TNIK,NTRK2,CAMK2G
3.273e-02	-3.42	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	18	16828	48	NAV2,GLIS3,APOE,TNC,RORA,CLU,TRPM3,MACF1,ADCY2,CDH20,PARD3,SORBS1,FMN2,LRP1B,CAMK2G,RYR3,NPAS3,CTNND2
3.287e-02	-3.42	Axon guidance	REACTOME pathways	R-HSA-422475	549	5	10285	34	ABLIM1,NRG3,ERBB4,CNTN1,CAMK2G
3.291e-02	-3.41	NCAN (neurocan)	protein interactions	1463	13	1	19454	50	TNC
3.291e-02	-3.41	RNASE4 (ribonuclease A family member 4)	protein interactions	6038	13	1	19454	50	LRP1B
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	JAM2 (junctional adhesion molecule 2)	protein interactions	58494	13	1	19454	50	PARD3
3.291e-02	-3.41	NPR2 (natriuretic peptide receptor 2)	protein interactions	4882	13	1	19454	50	CAMK2G
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	50	APOE
3.291e-02	-3.41	MYO16 (myosin XVI)	protein interactions	23026	13	1	19454	50	NRXN1
3.292e-02	-3.41	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	4	10285	34	NRG3,ERBB4,ADCY2,CAMK2G
3.305e-02	-3.41	CH	prosite domains	PS50021	81	2	12186	43	NAV2,MACF1
3.318e-02	-3.41	positive regulation of growth	biological process	GO:0045927	256	3	18204	50	ERBB4,PLCB1,MACF1
3.318e-02	-3.41	protein complex oligomerization	biological process	GO:0051259	256	3	18204	50	TRPM3,SLC1A2,RYR3
3.320e-02	-3.41	Fc epsilon receptor (FCERI) signaling	REACTOME pathways	R-HSA-2454202	372	4	10285	34	CAMK2G,MAPK10,NRG3,ERBB4
3.331e-02	-3.40	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	34	NRG3,ERBB4
3.350e-02	-3.40	cytoplasmic side of lysosomal membrane	cellular component	GO:0098574	13	1	19108	50	GFAP
3.350e-02	-3.40	chylomicron	cellular component	GO:0042627	13	1	19108	50	APOE
3.350e-02	-3.40	postsynaptic cytosol	cellular component	GO:0099524	13	1	19108	50	PLCB1
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	GPM6A,ERBB4
3.363e-02	-3.39	TSC22D4 (TSC22 domain family member 4)	protein interactions	81628	112	2	19454	50	ABLIM1,CLU
3.373e-02	-3.39	neural precursor cell proliferation	biological process	GO:0061351	105	2	18204	50	SOX5,RORA
3.373e-02	-3.39	gland morphogenesis	biological process	GO:0022612	105	2	18204	50	TNC,NRG3
3.373e-02	-3.39	response to interleukin-1	biological process	GO:0070555	105	2	18204	50	PLCB1,RORA
3.373e-02	-3.39	cellular response to alcohol	biological process	GO:0097306	105	2	18204	50	ADCY2,TNC
3.377e-02	-3.39	DCX	smart domains	SM00537	9	1	9717	37	DCLK2
3.381e-02	-3.39	positive regulation of developmental process	biological process	GO:0051094	1385	8	18204	50	ERBB4,SOX5,MACF1,NTRK2,NRXN1,PLCB1,GFAP,APOE
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.394e-02	-3.38	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	18	SLC4A4
3.402e-02	-3.38	steroid binding	molecular function	GO:0005496	107	2	18094	49	ATP1A2,RORA
3.432e-02	-3.37	cellular response to ketone	biological process	GO:1901655	106	2	18204	50	ADCY2,TNC
3.432e-02	-3.37	small_intestine	COSMIC cancer mutations	small_intestine	250	3	16828	48	MACF1,TNIK,MGAT4C
3.434e-02	-3.37	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	4	10285	34	ADCY2,ERBB4,NRG3,CAMK2G
3.457e-02	-3.36	TJP2 (tight junction protein 2)	protein interactions	9414	278	3	19454	50	PARD3,SORBS1,NEBL
3.460e-02	-3.36	phosphatidylinositol bisphosphate binding	molecular function	GO:1902936	108	2	18094	49	PARD3,PLCB1
3.462e-02	-3.36	Dimetindene H1-Antihistamine Action	SMPDB pathways	SMP0057582	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058923	8	1	1369	6	PLCB1
3.462e-02	-3.36	Phenbenzamine H1-Antihistamine Action	SMPDB pathways	SMP0059702	8	1	1369	6	PLCB1
3.462e-02	-3.36	Azatadine H1-Antihistamine Action	SMPDB pathways	SMP0059865	8	1	1369	6	PLCB1
3.462e-02	-3.36	Quetiapine H1-Antihistamine Action	SMPDB pathways	SMP0062884	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chlorphenamine H1-Antihistamine Action	SMPDB pathways	SMP0056661	8	1	1369	6	PLCB1
3.462e-02	-3.36	Tolpropamine H1-Antihistamine Action	SMPDB pathways	SMP0062621	8	1	1369	6	PLCB1
3.462e-02	-3.36	Quifenadine H1-Antihistamine Action	SMPDB pathways	SMP0060743	8	1	1369	6	PLCB1
3.462e-02	-3.36	Hydroxyzine H1-Antihistamine Action	SMPDB pathways	SMP0058936	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mebhydrolin H1-Antihistamine Action	SMPDB pathways	SMP0061052	8	1	1369	6	PLCB1
3.462e-02	-3.36	Talastine H1-Antihistamine Action	SMPDB pathways	SMP0057586	8	1	1369	6	PLCB1
3.462e-02	-3.36	Histapyrrodine H1-Antihistamine Action	SMPDB pathways	SMP0058732	8	1	1369	6	PLCB1
3.462e-02	-3.36	Pyrrobutamine H1-Antihistamine Action	SMPDB pathways	SMP0062887	8	1	1369	6	PLCB1
3.462e-02	-3.36	Astemizole H1-Antihistamine Action	SMPDB pathways	SMP0059897	8	1	1369	6	PLCB1
3.462e-02	-3.36	Promethazine H1-Antihistamine Action	SMPDB pathways	SMP0059211	8	1	1369	6	PLCB1
3.462e-02	-3.36	Ketotifen H1-Antihistamine Action	SMPDB pathways	SMP0059868	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thenalidine H1-Antihistamine Action	SMPDB pathways	SMP0062894	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thiazinamium H1-Antihistamine Action	SMPDB pathways	SMP0060742	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bromodiphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058813	8	1	1369	6	PLCB1
3.462e-02	-3.36	Emedastine H1-Antihistamine Action	SMPDB pathways	SMP0061040	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mepyramine H1-Antihistamine Action	SMPDB pathways	SMP0057583	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059058	8	1	1369	6	PLCB1
3.462e-02	-3.36	Azelastine H1-Antihistamine Action	SMPDB pathways	SMP0060741	8	1	1369	6	PLCB1
3.462e-02	-3.36	Latrepirdine H1-Antihistamine Action	SMPDB pathways	SMP0062623	8	1	1369	6	PLCB1
3.462e-02	-3.36	Dexchlorpheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056811	8	1	1369	6	PLCB1
3.462e-02	-3.36	Orphenadrine H1-Antihistamine Action	SMPDB pathways	SMP0058808	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chlorphenoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058903	8	1	1369	6	PLCB1
3.462e-02	-3.36	Desloratadine H1-Antihistamine Action	SMPDB pathways	SMP0060201	8	1	1369	6	PLCB1
3.462e-02	-3.36	Flunarizine H1-Antihistamine Action	SMPDB pathways	SMP0061047	8	1	1369	6	PLCB1
3.462e-02	-3.36	Tritoqualine H1-Antihistamine Action	SMPDB pathways	SMP0062895	8	1	1369	6	PLCB1
3.462e-02	-3.36	Hydroxyethylpromethazine H1-Antihistamine Action	SMPDB pathways	SMP0059710	8	1	1369	6	PLCB1
3.462e-02	-3.36	Fexofenadine H1-Antihistamine Action	SMPDB pathways	SMP0060218	8	1	1369	6	PLCB1
3.462e-02	-3.36	Pheniramine H1-Antihistamine Action	SMPDB pathways	SMP0056662	8	1	1369	6	PLCB1
3.462e-02	-3.36	Temelastine H1-Antihistamine Action	SMPDB pathways	SMP0062880	8	1	1369	6	PLCB1
3.462e-02	-3.36	Triprolidine H1-Antihistamine Action	SMPDB pathways	SMP0057581	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0058931	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mirtazapine H1-Antihistamine Action	SMPDB pathways	SMP0062885	8	1	1369	6	PLCB1
3.462e-02	-3.36	Embramine H1-Antihistamine Action	SMPDB pathways	SMP0062622	8	1	1369	6	PLCB1
3.462e-02	-3.36	Meclizine H1-Antihistamine Action	SMPDB pathways	SMP0058956	8	1	1369	6	PLCB1
3.462e-02	-3.36	Epinastine H1-Antihistamine Action	SMPDB pathways	SMP0061191	8	1	1369	6	PLCB1
3.462e-02	-3.36	Lysophosphatidic Acid LPA3 Signalling	SMPDB pathways	SMP0063755	8	1	1369	6	PLCB1
3.462e-02	-3.36	Phenindamine H1-Antihistamine Action	SMPDB pathways	SMP0061190	8	1	1369	6	PLCB1
3.462e-02	-3.36	Diphenhydramine H1-Antihistamine Action	SMPDB pathways	SMP0058785	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bilastine H1-Antihistamine Action	SMPDB pathways	SMP0060170	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thenyldiamine H1-Antihistamine Action	SMPDB pathways	SMP0062624	8	1	1369	6	PLCB1
3.462e-02	-3.36	Chloropyramine H1-Antihistamine Action	SMPDB pathways	SMP0057585	8	1	1369	6	PLCB1
3.462e-02	-3.36	Thonzylamine H1-Antihistamine Action	SMPDB pathways	SMP0058769	8	1	1369	6	PLCB1
3.462e-02	-3.36	Dexbrompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057580	8	1	1369	6	PLCB1
3.462e-02	-3.36	Alcaftadine H1-Antihistamine Action	SMPDB pathways	SMP0062881	8	1	1369	6	PLCB1
3.462e-02	-3.36	Levocabastine H1-Antihistamine Action	SMPDB pathways	SMP0060224	8	1	1369	6	PLCB1
3.462e-02	-3.36	Alimemazine H1-Antihistamine Action	SMPDB pathways	SMP0059689	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cyproheptadine H1-Antihistamine Action	SMPDB pathways	SMP0059694	8	1	1369	6	PLCB1
3.462e-02	-3.36	Cinnarizine H1-Antihistamine Action	SMPDB pathways	SMP0059110	8	1	1369	6	PLCB1
3.462e-02	-3.36	Terfenadine H1-Antihistamine Action	SMPDB pathways	SMP0060208	8	1	1369	6	PLCB1
3.462e-02	-3.36	Loratadine H1-Antihistamine Action	SMPDB pathways	SMP0060195	8	1	1369	6	PLCB1
3.462e-02	-3.36	Methapyrilene H1-Antihistamine Action	SMPDB pathways	SMP0058741	8	1	1369	6	PLCB1
3.462e-02	-3.36	Buclizine H1-Antihistamine Action	SMPDB pathways	SMP0058964	8	1	1369	6	PLCB1
3.462e-02	-3.36	Olopatadine H1-Antihistamine Action	SMPDB pathways	SMP0060740	8	1	1369	6	PLCB1
3.462e-02	-3.36	Phenyltoloxamine H1-Antihistamine Action	SMPDB pathways	SMP0058916	8	1	1369	6	PLCB1
3.462e-02	-3.36	Acrivastine H1-Antihistamine Action	SMPDB pathways	SMP0059881	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bepotastine H1-Antihistamine Action	SMPDB pathways	SMP0060058	8	1	1369	6	PLCB1
3.462e-02	-3.36	Clocinizine H1-Antihistamine Action	SMPDB pathways	SMP0062788	8	1	1369	6	PLCB1
3.462e-02	-3.36	Carbinoxamine H1-Antihistamine Action	SMPDB pathways	SMP0058797	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mequitazine H1-Antihistamine Action	SMPDB pathways	SMP0059720	8	1	1369	6	PLCB1
3.462e-02	-3.36	Deptropine H1-Antihistamine Action	SMPDB pathways	SMP0062883	8	1	1369	6	PLCB1
3.462e-02	-3.36	Brompheniramine H1-Antihistamine Action	SMPDB pathways	SMP0057579	8	1	1369	6	PLCB1
3.462e-02	-3.36	Mizolastine H1-Antihistamine Action	SMPDB pathways	SMP0060230	8	1	1369	6	PLCB1
3.462e-02	-3.36	Levocetirizine H1-Antihistamine Action	SMPDB pathways	SMP0059114	8	1	1369	6	PLCB1
3.462e-02	-3.36	Doxepin H1-Antihistamine Action	SMPDB pathways	SMP0059872	8	1	1369	6	PLCB1
3.462e-02	-3.36	Ebastine H1-Antihistamine Action	SMPDB pathways	SMP0060204	8	1	1369	6	PLCB1
3.462e-02	-3.36	Isothipendyl H1-Antihistamine Action	SMPDB pathways	SMP0059716	8	1	1369	6	PLCB1
3.462e-02	-3.36	Rupatadine H1-Antihistamine Action	SMPDB pathways	SMP0060235	8	1	1369	6	PLCB1
3.462e-02	-3.36	Betahistine H1-Antihistamine Action	SMPDB pathways	SMP0060744	8	1	1369	6	PLCB1
3.462e-02	-3.36	Clemastine H1-Antihistamine Action	SMPDB pathways	SMP0058891	8	1	1369	6	PLCB1
3.462e-02	-3.36	Pimethixene H1-Antihistamine Action	SMPDB pathways	SMP0062886	8	1	1369	6	PLCB1
3.462e-02	-3.36	Fenethazine H1-Antihistamine Action	SMPDB pathways	SMP0059707	8	1	1369	6	PLCB1
3.462e-02	-3.36	Histamine H1 Receptor Activation	SMPDB pathways	SMP0063452	8	1	1369	6	PLCB1
3.462e-02	-3.36	Doxylamine H1-Antihistamine Action	SMPDB pathways	SMP0058803	8	1	1369	6	PLCB1
3.462e-02	-3.36	Tripelennamine H1-Antihistamine Action	SMPDB pathways	SMP0057587	8	1	1369	6	PLCB1
3.462e-02	-3.36	Homochlorcyclizine H1-Antihistamine Action	SMPDB pathways	SMP0062795	8	1	1369	6	PLCB1
3.462e-02	-3.36	Antazoline H1-Antihistamine Action	SMPDB pathways	SMP0057584	8	1	1369	6	PLCB1
3.462e-02	-3.36	Propiomazine H1-Antihistamine Action	SMPDB pathways	SMP0062625	8	1	1369	6	PLCB1
3.462e-02	-3.36	Oxomemazine H1-Antihistamine Action	SMPDB pathways	SMP0059738	8	1	1369	6	PLCB1
3.462e-02	-3.36	Bamipine H1-Antihistamine Action	SMPDB pathways	SMP0062882	8	1	1369	6	PLCB1
3.462e-02	-3.36	Oxatomide H1-Antihistamine Action	SMPDB pathways	SMP0059044	8	1	1369	6	PLCB1
3.462e-02	-3.36	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	6	ADCY2
3.462e-02	-3.36	Methdilazine H1-Antihistamine Action	SMPDB pathways	SMP0059730	8	1	1369	6	PLCB1
3.462e-02	-3.36	Diphenylpyraline H1-Antihistamine Action	SMPDB pathways	SMP0058908	8	1	1369	6	PLCB1
3.465e-02	-3.36	potassium ion binding	molecular function	GO:0030955	13	1	18094	49	ATP1A2
3.465e-02	-3.36	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	49	SLC4A4
3.469e-02	-3.36	negative regulation of protein metabolic process	biological process	GO:0051248	893	6	18204	50	APOE,CLU,CST3,FMN2,PARD3,NTRK2
3.474e-02	-3.36	MIR	prosite domains	PS50919	10	1	12186	43	RYR3
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	RYR3,TRPM3
3.514e-02	-3.35	phospholipid efflux	biological process	GO:0033700	13	1	18204	50	APOE
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	postsynaptic specialization assembly	biological process	GO:0098698	13	1	18204	50	NRXN1
3.514e-02	-3.35	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	50	RORA
3.514e-02	-3.35	nervous system process involved in regulation of systemic arterial blood pressure	biological process	GO:0001976	13	1	18204	50	NAV2
3.514e-02	-3.35	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	50	APOE
3.514e-02	-3.35	ectodermal placode development	biological process	GO:0071696	13	1	18204	50	NRG3
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	50	PRKG1
3.514e-02	-3.35	cellular response to vitamin D	biological process	GO:0071305	13	1	18204	50	TNC
3.514e-02	-3.35	prepulse inhibition	biological process	GO:0060134	13	1	18204	50	CTNNA2
3.514e-02	-3.35	olfactory bulb interneuron differentiation	biological process	GO:0021889	13	1	18204	50	ERBB4
3.514e-02	-3.35	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	50	RORA
3.514e-02	-3.35	bile_duct	COSMIC cancer mutations	bile_duct	15095	47	16828	48	DGKG,CNTN1,NTRK2,MSI2,MGAT4C,GFAP,SORBS1,FMN2,GPM6A,RYR3,DCLK2,SLC14A1,ABLIM1,SOX5,SLC4A4,TRPM3,CDH20,ADCY2,PARD3,NPAS3,CTNND2,ERBB4,NAV2,GLIS3,SLC1A2,TNC,APOE,NRXN1,ATP1A2,PITPNC1,LRP1B,PLCB1,TNIK,CST3,NRG3,RFX4,RORA,LSAMP,CLU,MACF1,HPSE2,NEBL,PRKG1,NTM,GPC5,CAMK2G,DTNA
3.514e-02	-3.35	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	47	16828	48	RFX4,NRG3,CST3,HPSE2,MACF1,RORA,CLU,LSAMP,NEBL,GPC5,DTNA,CAMK2G,PRKG1,NTM,GLIS3,NAV2,ERBB4,NRXN1,SLC1A2,TNC,APOE,ATP1A2,PITPNC1,LRP1B,TNIK,PLCB1,SLC14A1,DCLK2,TRPM3,ABLIM1,SOX5,SLC4A4,CDH20,ADCY2,NPAS3,CTNND2,PARD3,DGKG,MSI2,CNTN1,NTRK2,MGAT4C,RYR3,GFAP,GPM6A,SORBS1,FMN2
3.522e-02	-3.35	Ldl_recept_b	pfam domains	PF00058	13	1	17795	49	LRP1B
3.530e-02	-3.34	CDH2 (cadherin 2)	protein interactions	1000	115	2	19454	50	CTNND2,PARD3
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	SOX5,PARD3
3.530e-02	-3.34	DTNA (dystrobrevin alpha)	protein interactions	1837	115	2	19454	50	PARD3,NTRK2
3.539e-02	-3.34	HRAS (HRas proto-oncogene, GTPase)	protein interactions	3265	712	5	19454	50	NAV2,MAPK10,PLCB1,PARD3,TNIK
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	GAGE1 (G antigen 1)	protein interactions	2543	14	1	19454	50	PRKG1
3.540e-02	-3.34	SYT5 (synaptotagmin 5)	protein interactions	6861	14	1	19454	50	NRXN1
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	50	CST3
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	CAMK2G
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	LRP1B
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	CAMK2G
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	TPSAB1 (tryptase alpha/beta 1)	protein interactions	7177	14	1	19454	50	CAMK2G
3.540e-02	-3.34	CABS1 (calcium binding protein, spermatid associated 1)	protein interactions	85438	14	1	19454	50	GFAP
3.540e-02	-3.34	CFAP58 (cilia and flagella associated protein 58)	protein interactions	159686	14	1	19454	50	NAV2
3.540e-02	-3.34	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	50	APOE
3.540e-02	-3.34	SH3YL1 (SH3 and SYLF domain containing 1)	protein interactions	26751	14	1	19454	50	GFAP
3.544e-02	-3.34	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	34	NRG3,ERBB4
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.578e-02	-3.33	structural constituent of cytoskeleton	molecular function	GO:0005200	110	2	18094	49	CTNNA2,GFAP
3.586e-02	-3.33	RBBP8 (RB binding protein 8, endonuclease)	protein interactions	5932	116	2	19454	50	CTNNA2,CLU
3.586e-02	-3.33	FCGRT (Fc gamma receptor and transporter)	protein interactions	2217	116	2	19454	50	CLU,CNTN1
3.588e-02	-3.33	cGMP signaling	KEGG pathways	hsa_M00694	9	1	7161	29	PRKG1
3.588e-02	-3.33	cGMP signaling	KEGG pathways	M00694	9	1	7161	29	PRKG1
3.588e-02	-3.33	Heparan sulfate degradation	KEGG pathways	M00078	9	1	7161	29	HPSE2
3.588e-02	-3.33	Heparan sulfate degradation	KEGG pathways	hsa_M00078	9	1	7161	29	HPSE2
3.589e-02	-3.33	plasma membrane raft	cellular component	GO:0044853	114	2	19108	50	SORBS1,ATP1A2
3.592e-02	-3.33	regulation of MAPK cascade	biological process	GO:0043408	669	5	18204	50	APOE,PLCB1,ERBB4,NTRK2,TNIK
3.592e-02	-3.33	PRKACA (protein kinase cAMP-activated catalytic subunit alpha)	protein interactions	5566	486	4	19454	50	PARD3,GFAP,TNIK,SLC4A4
3.603e-02	-3.32	chromaffin granule	cellular component	GO:0042583	14	1	19108	50	CLU
3.620e-02	-3.32	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	50	GPC5,APOE,CTNND2
3.627e-02	-3.32	Ion_trans	pfam domains	PF00520	109	2	17795	49	TRPM3,RYR3
3.635e-02	-3.31	Chemokine signaling pathway	KEGG pathways	ko04062	182	3	7161	29	ADCY2,PLCB1,PARD3
3.635e-02	-3.31	Chemokine signaling pathway	KEGG pathways	hsa04062	182	3	7161	29	ADCY2,PLCB1,PARD3
3.647e-02	-3.31	Dppa3 (developmental pluripotency-associated 3)	protein interactions	73708	284	3	19454	50	ATP1A2,MSI2,CAMK2G
3.668e-02	-3.31	CAV1 (caveolin 1)	protein interactions	857	719	5	19454	50	DTNA,TNIK,MACF1,PARD3,FMN2
3.670e-02	-3.30	-	gene3d domains	3.10.450.50	12	1	14470	45	CAMK2G
3.670e-02	-3.30	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	45	CTNNA2
3.670e-02	-3.30	EV release from cardiac cells and their functional effects	WikiPathways	WP3297	9	1	5310	22	ERBB4
3.672e-02	-3.30	positive regulation of cell junction assembly	biological process	GO:1901890	110	2	18204	50	NTRK2,NRXN1
3.676e-02	-3.30	heterocyclic compound binding	molecular function	GO:1901363	2263	11	18094	49	DCLK2,ERBB4,NAV2,MAPK10,DGKG,NTRK2,PRKG1,ATP1A2,TNIK,CAMK2G,ADCY2
3.677e-02	-3.30	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	5	16828	48	TNIK,ABLIM1,PRKG1,TRPM3,MACF1
3.689e-02	-3.30	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	34	LSAMP,NTM
3.694e-02	-3.30	sulfur compound binding	molecular function	GO:1901681	271	3	18094	49	APOE,HPSE2,NAV2
3.699e-02	-3.30	SIPA1L2 (signal induced proliferation associated 1 like 2)	protein interactions	57568	118	2	19454	50	PARD3,GFAP
3.699e-02	-3.30	CEACAM8 (CEA cell adhesion molecule 8)	protein interactions	1088	118	2	19454	50	APOE,CLU
3.702e-02	-3.30	TyrKc	smart domains	SM00219	80	2	9717	37	NTRK2,ERBB4
3.704e-02	-3.30	blood microparticle	cellular component	GO:0072562	116	2	19108	50	APOE,CLU
3.715e-02	-3.29	LDLR_classB_rpt	interpro domains	IPR000033	14	1	18521	50	LRP1B
3.715e-02	-3.29	Neurexin-like	interpro domains	IPR003585	14	1	18521	50	NRXN1
3.715e-02	-3.29	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	48	FMN2,SLC4A4,CNTN1
3.717e-02	-3.29	regulation of phosphate metabolic process	biological process	GO:0019220	1154	7	18204	50	APOE,NTRK2,TNIK,PRKG1,PARD3,SLC4A4,ERBB4
3.727e-02	-3.29	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	49	MACF1
3.727e-02	-3.29	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	1	18094	49	SLC1A2
3.732e-02	-3.29	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	7	18204	50	PRKG1,ERBB4,PARD3,SLC4A4,APOE,TNIK,NTRK2
3.735e-02	-3.29	bladder	COSMIC cancer mutations	bladder	14112	45	16828	48	CTNND2,NPAS3,PARD3,ADCY2,CDH20,TRPM3,SLC4A4,SOX5,ABLIM1,SLC14A1,DCLK2,RYR3,FMN2,SORBS1,GPM6A,GFAP,MGAT4C,MSI2,NTRK2,CNTN1,DGKG,CAMK2G,DTNA,GPC5,NTM,PRKG1,NEBL,HPSE2,MACF1,CLU,LSAMP,RORA,NRG3,RFX4,TNIK,PLCB1,LRP1B,PITPNC1,ATP1A2,NRXN1,TNC,SLC1A2,GLIS3,NAV2,ERBB4
3.735e-02	-3.29	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	45	16828	48	PITPNC1,ATP1A2,PLCB1,TNIK,LRP1B,GLIS3,ERBB4,NAV2,NRXN1,TNC,SLC1A2,NEBL,CAMK2G,DTNA,GPC5,NTM,PRKG1,RFX4,NRG3,MACF1,HPSE2,LSAMP,CLU,RORA,MGAT4C,RYR3,GPM6A,SORBS1,FMN2,GFAP,DGKG,MSI2,NTRK2,CNTN1,ADCY2,CDH20,CTNND2,NPAS3,PARD3,SLC14A1,DCLK2,TRPM3,SLC4A4,SOX5,ABLIM1
3.745e-02	-3.28	DAGKa	smart domains	SM00045	10	1	9717	37	DGKG
3.745e-02	-3.28	MIR	smart domains	SM00472	10	1	9717	37	RYR3
3.756e-02	-3.28	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	50	CLU,APOE
3.756e-02	-3.28	ANKRD26 (ankyrin repeat domain containing 26)	protein interactions	22852	119	2	19454	50	PARD3,NTRK2
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.779e-02	-3.28	cellular response to forskolin	biological process	GO:1904322	14	1	18204	50	ADCY2
3.779e-02	-3.28	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	50	APOE
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.779e-02	-3.28	mechanosensory behavior	biological process	GO:0007638	14	1	18204	50	NRXN1
3.779e-02	-3.28	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	50	APOE
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	response to forskolin	biological process	GO:1904321	14	1	18204	50	ADCY2
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	protein localization to postsynaptic specialization membrane	biological process	GO:0099633	14	1	18204	50	ERBB4
3.779e-02	-3.28	neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0099645	14	1	18204	50	ERBB4
3.779e-02	-3.28	regulation of skeletal muscle adaptation	biological process	GO:0014733	14	1	18204	50	CAMK2G
3.788e-02	-3.27	NPR1 (natriuretic peptide receptor 1)	protein interactions	4881	15	1	19454	50	PRKG1
3.788e-02	-3.27	DEFB123 (defensin beta 123)	protein interactions	245936	15	1	19454	50	LRP1B
3.788e-02	-3.27	PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	27344	15	1	19454	50	MGAT4C
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CLU
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	OLFM3 (olfactomedin 3)	protein interactions	118427	15	1	19454	50	LRP1B
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.794e-02	-3.27	rhythmic process	biological process	GO:0048511	270	3	18204	50	MAPK10,NTRK2,RORA
3.796e-02	-3.27	regulation of membrane potential	biological process	GO:0042391	463	4	18204	50	NRXN1,NTRK2,SLC4A4,ATP1A2
3.797e-02	-3.27	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	3	18094	49	ATP1A2,SLC4A4,SLC1A2
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	SORBS1,NEBL,ABLIM1
3.815e-02	-3.27	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	43	NTRK2
3.818e-02	-3.27	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	8	16828	48	RYR3,CTNND2,HPSE2,MACF1,TRPM3,LRP1B,ATP1A2,ERBB4
3.837e-02	-3.26	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	34	ERBB4,NRG3
3.855e-02	-3.26	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	50	APOE
3.855e-02	-3.26	axolemma	cellular component	GO:0030673	15	1	19108	50	SLC1A2
3.866e-02	-3.25	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	49	PLCB1,PITPNC1,PARD3
3.873e-02	-3.25	regulation of monoatomic ion transport	biological process	GO:0043269	466	4	18204	50	CAMK2G,CNTN1,ATP1A2,NKAIN3
3.873e-02	-3.25	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	41	16828	48	NTM,PARD3,PRKG1,NPAS3,CTNND2,GPC5,NEBL,ADCY2,CDH20,SOX5,RORA,ABLIM1,LSAMP,CLU,TRPM3,HPSE2,MACF1,SLC14A1,NRG3,RFX4,GFAP,PLCB1,GPM6A,FMN2,TNIK,SORBS1,LRP1B,RYR3,MGAT4C,ATP1A2,PITPNC1,SLC1A2,NTRK2,NKAIN3,TNC,CNTN1,NRXN1,ERBB4,NAV2,DGKG,GLIS3
3.884e-02	-3.25	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	47	16828	48	ATP1A2,PITPNC1,LRP1B,PLCB1,TNIK,NAV2,ERBB4,GLIS3,SLC1A2,APOE,NKAIN3,TNC,NRXN1,NEBL,PRKG1,NTM,GPC5,DTNA,CAMK2G,RFX4,NRG3,RORA,LSAMP,CLU,MACF1,HPSE2,MGAT4C,GFAP,SORBS1,GPM6A,FMN2,RYR3,DGKG,CNTN1,NTRK2,MSI2,CDH20,ADCY2,PARD3,NPAS3,CTNND2,DCLK2,SLC14A1,ABLIM1,SLC4A4,SOX5,TRPM3
3.887e-02	-3.25	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	18	16828	48	GLIS3,NAV2,MACF1,TRPM3,CLU,RORA,TNC,APOE,CDH20,ADCY2,CTNND2,NPAS3,RYR3,CAMK2G,LRP1B,FMN2,SORBS1,PARD3
3.887e-02	-3.25	Lysophosphatidic Acid LPA1 Signalling	SMPDB pathways	SMP0063746	9	1	1369	6	PLCB1
3.887e-02	-3.25	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	6	ADCY2
3.887e-02	-3.25	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	6	ADCY2
3.887e-02	-3.25	Lysophosphatidic Acid LPA2 Signalling	SMPDB pathways	SMP0063753	9	1	1369	6	PLCB1
3.887e-02	-3.25	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	6	ADCY2
3.887e-02	-3.25	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	6	ADCY2
3.887e-02	-3.25	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	6	ADCY2
3.896e-02	-3.25	EGF_2	prosite domains	PS01186	213	3	12186	43	TNC,NRG3,LRP1B
3.898e-02	-3.24	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	34	GPC5
3.898e-02	-3.24	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	34	GPC5
3.898e-02	-3.24	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	3	16828	48	RYR3,SLC1A2,SOX5
3.918e-02	-3.24	negative regulation of protein catabolic process	biological process	GO:0042177	114	2	18204	50	FMN2,CST3
3.918e-02	-3.24	negative regulation of small molecule metabolic process	biological process	GO:0062014	114	2	18204	50	PRKG1,APOE
3.930e-02	-3.24	SLMAP (sarcolemma associated protein)	protein interactions	7871	122	2	19454	50	CAMK2G,TNIK
3.935e-02	-3.24	skin-acral-malignant_melanoma	COSMIC cancer mutations	skin-acral-malignant_melanoma	264	3	16828	48	FMN2,PARD3,CDH20
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.950e-02	-3.23	basal plasma membrane	cellular component	GO:0009925	288	3	19108	50	ERBB4,SLC4A4,SLC14A1
3.956e-02	-3.23	import into cell	biological process	GO:0098657	687	5	18204	50	LRP1B,GFAP,ATP1A2,APOE,SLC1A2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	NTF2-like_dom_sf	interpro domains	IPR032710	15	1	18521	50	CAMK2G
3.975e-02	-3.23	Diacylglycerol_kinase_cat_dom	interpro domains	IPR001206	15	1	18521	50	DGKG
3.975e-02	-3.23	PLipase_C_Pinositol-sp_Y	interpro domains	IPR001711	15	1	18521	50	PLCB1
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.975e-02	-3.23	PI-PLC_fam	interpro domains	IPR001192	15	1	18521	50	PLCB1
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.988e-02	-3.22	tropomyosin binding	molecular function	GO:0005523	15	1	18094	49	NEBL
3.988e-02	-3.22	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	49	PITPNC1
3.988e-02	-3.22	low-density lipoprotein particle receptor activity	molecular function	GO:0005041	15	1	18094	49	LRP1B
3.988e-02	-3.22	filamin binding	molecular function	GO:0031005	15	1	18094	49	NEBL
3.988e-02	-3.22	3'-5' DNA helicase activity	molecular function	GO:0043138	15	1	18094	49	NAV2
3.988e-02	-3.22	EF_HAND_2	prosite domains	PS50222	215	3	12186	43	RYR3,DGKG,MACF1
3.988e-02	-3.22	ITPR1 (inositol 1,4,5-trisphosphate receptor type 1)	protein interactions	3708	123	2	19454	50	PRKG1,CAMK2G
3.988e-02	-3.22	GNAQ (G protein subunit alpha q)	protein interactions	2776	123	2	19454	50	GPM6A,PLCB1
4.002e-02	-3.22	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	2	18094	49	SLC1A2,SLC4A4
4.019e-02	-3.21	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	8	16828	48	RYR3,HPSE2,CTNND2,MACF1,TRPM3,LRP1B,ERBB4,ATP1A2
4.020e-02	-3.21	MAPRE1 (microtubule associated protein RP/EB family member 1)	protein interactions	22919	504	4	19454	50	MACF1,CAMK2G,ABLIM1,NAV2
4.035e-02	-3.21	DUS1L (dihydrouridine synthase 1 like)	protein interactions	64118	16	1	19454	50	CAMK2G
4.035e-02	-3.21	CAMK1G (calcium/calmodulin dependent protein kinase IG)	protein interactions	57172	16	1	19454	50	CAMK2G
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKG1
4.035e-02	-3.21	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	50	APOE
4.035e-02	-3.21	TMEM134 (transmembrane protein 134)	protein interactions	80194	16	1	19454	50	ERBB4
4.035e-02	-3.21	SYTL2 (synaptotagmin like 2)	protein interactions	54843	16	1	19454	50	NRXN1
4.035e-02	-3.21	SYT9 (synaptotagmin 9)	protein interactions	143425	16	1	19454	50	NRXN1
4.035e-02	-3.21	SYT4 (synaptotagmin 4)	protein interactions	6860	16	1	19454	50	NRXN1
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	IFFO2 (intermediate filament family orphan 2)	protein interactions	126917	16	1	19454	50	GFAP
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	MACF1
4.036e-02	-3.21	skin-malignant_melanoma	COSMIC cancer mutations	skin-malignant_melanoma	15741	48	16828	48	CST3,RFX4,NRG3,RORA,LSAMP,CLU,HPSE2,MACF1,NEBL,NTM,PRKG1,CAMK2G,DTNA,GPC5,ERBB4,NAV2,GLIS3,SLC1A2,NKAIN3,APOE,TNC,NRXN1,ATP1A2,PITPNC1,PLCB1,TNIK,LRP1B,DCLK2,SLC14A1,SOX5,SLC4A4,ABLIM1,TRPM3,ADCY2,CDH20,PARD3,NPAS3,CTNND2,DGKG,NTRK2,CNTN1,MSI2,MGAT4C,GFAP,SORBS1,GPM6A,FMN2,RYR3
4.042e-02	-3.21	Phenytoin (Antiarrhythmic) Action Pathway	SMPDB pathways	SMP0000327	77	2	1369	6	ATP1A2,PLCB1
4.043e-02	-3.21	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	50	APOE
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	50	SORBS1
4.043e-02	-3.21	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	50	RORA
4.043e-02	-3.21	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	50	APOE
4.043e-02	-3.21	pyramidal neuron differentiation	biological process	GO:0021859	15	1	18204	50	DCLK2
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	negative regulation of amino acid transport	biological process	GO:0051956	15	1	18204	50	PRKG1
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	1	18204	50	PRKG1
4.043e-02	-3.21	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	50	NTRK2
4.043e-02	-3.21	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	50	NTRK2
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.043e-02	-3.21	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	50	MACF1
4.043e-02	-3.21	regulation of phospholipid transport	biological process	GO:2001138	15	1	18204	50	APOE
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	collateral sprouting	biological process	GO:0048668	15	1	18204	50	PRKG1
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.047e-02	-3.21	CEBPA (CCAAT enhancer binding protein alpha)	protein interactions	1050	124	2	19454	50	MACF1,GFAP
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	FMN2
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	PI-PLC-Y	pfam domains	PF00387	15	1	17795	49	PLCB1
4.053e-02	-3.21	DAGK_cat	pfam domains	PF00781	15	1	17795	49	DGKG
4.061e-02	-3.20	stomach-carcinoma-adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-adenocarcinoma	15150	47	16828	48	ATP1A2,PITPNC1,TNIK,PLCB1,LRP1B,ERBB4,NAV2,GLIS3,SLC1A2,APOE,TNC,NRXN1,NEBL,NTM,PRKG1,CAMK2G,DTNA,GPC5,CST3,NRG3,RFX4,RORA,LSAMP,CLU,MACF1,HPSE2,MGAT4C,GFAP,GPM6A,FMN2,SORBS1,RYR3,DGKG,NTRK2,CNTN1,MSI2,ADCY2,CDH20,PARD3,NPAS3,CTNND2,DCLK2,SLC14A1,SOX5,SLC4A4,ABLIM1,TRPM3
4.069e-02	-3.20	LZTS2 (leucine zipper tumor suppressor 2)	protein interactions	84445	506	4	19454	50	PARD3,NEBL,GFAP,SORBS1
4.070e-02	-3.20	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	22	APOE
4.077e-02	-3.20	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	21	16828	48	PRKG1,LRP1B,PLCB1,TNIK,PARD3,CTNND2,NPAS3,CAMK2G,PITPNC1,ADCY2,CLU,LSAMP,CNTN1,ABLIM1,RORA,NTRK2,SOX5,MSI2,DCLK2,DGKG,ERBB4
4.077e-02	-3.20	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	21	16828	48	MSI2,SOX5,NTRK2,RORA,ABLIM1,CNTN1,LSAMP,CLU,ERBB4,DGKG,DCLK2,CAMK2G,NPAS3,CTNND2,PARD3,PLCB1,TNIK,LRP1B,PRKG1,ADCY2,PITPNC1
4.077e-02	-3.20	positive regulation of response to stimulus	biological process	GO:0048584	2266	11	18204	50	MACF1,ERBB4,GPC5,FMN2,CLU,SORBS1,APOE,NRXN1,TNIK,NTRK2,PLCB1
4.079e-02	-3.20	TJP1 (tight junction protein 1)	protein interactions	7082	297	3	19454	50	PARD3,NEBL,DTNA
4.080e-02	-3.20	actin filament organization	biological process	GO:0007015	278	3	18204	50	FMN2,NEBL,SORBS1
4.085e-02	-3.20	acral	COSMIC cancer mutations	acral	268	3	16828	48	PARD3,FMN2,CDH20
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	NTM,CNTN1,LSAMP,NTRK2
4.106e-02	-3.19	TCHP (trichoplein keratin filament binding)	protein interactions	84260	125	2	19454	50	PARD3,GFAP
4.107e-02	-3.19	regulation of synapse assembly	biological process	GO:0051963	117	2	18204	50	NRXN1,NTRK2
4.107e-02	-3.19	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	50	TNIK
4.127e-02	-3.19	human chr3q13.31	chromosome location	human chr3q13.31	22	1	26134	50	LSAMP
4.155e-02	-3.18	CNMP_BINDING_2	prosite domains	PS00889	12	1	12186	43	PRKG1
4.155e-02	-3.18	MAPK	prosite domains	PS01351	12	1	12186	43	MAPK10
4.159e-02	-3.18	circulatory system development	biological process	GO:0072359	933	6	18204	50	NTRK2,RORA,APOE,ERBB4,NEBL,PRKG1
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.193e-02	-3.17	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	50	NRG3,PLCB1,MAPK10,TNIK,NTRK2,SORBS1,CNTN1,ERBB4,MACF1,CTNND2
4.195e-02	-3.17	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	14	18204	50	ERBB4,CNTN1,GLIS3,SLC4A4,TNC,APOE,RFX4,NTRK2,TNIK,NPAS3,PLCB1,SORBS1,CLU,RORA
4.216e-02	-3.17	ARRB1 (arrestin beta 1)	protein interactions	408	301	3	19454	50	LRP1B,MAPK10,DGKG
4.226e-02	-3.16	DES (desmin)	protein interactions	1674	127	2	19454	50	DTNA,GFAP
4.235e-02	-3.16	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	50	PRKG1
4.248e-02	-3.16	MAP kinase activity	molecular function	GO:0004707	16	1	18094	49	MAPK10
4.248e-02	-3.16	misfolded protein binding	molecular function	GO:0051787	16	1	18094	49	CLU
4.248e-02	-3.16	cGMP binding	molecular function	GO:0030553	16	1	18094	49	PRKG1
4.248e-02	-3.16	oxysterol binding	molecular function	GO:0008142	16	1	18094	49	RORA
4.248e-02	-3.16	MAP kinase kinase activity	molecular function	GO:0004708	16	1	18094	49	MAPK10
4.248e-02	-3.16	lamin binding	molecular function	GO:0005521	16	1	18094	49	PLCB1
4.248e-02	-3.16	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	49	ADCY2
4.265e-02	-3.15	Wnt signaling pathway	biological process	GO:0016055	283	3	18204	50	TNIK,CTNND2,MACF1
4.269e-02	-3.15	-	gene3d domains	2.20.25.10	14	1	14470	45	TNC
4.269e-02	-3.15	-	gene3d domains	2.60.200.40	14	1	14470	45	DGKG
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	CNTN2 (contactin 2)	protein interactions	6900	17	1	19454	50	CNTN1
4.282e-02	-3.15	CLEC4M (C-type lectin domain family 4 member M)	protein interactions	10332	17	1	19454	50	GFAP
4.282e-02	-3.15	SCN1B (sodium voltage-gated channel beta subunit 1)	protein interactions	6324	17	1	19454	50	CNTN1
4.282e-02	-3.15	SHD (Src homology 2 domain containing transforming protein D)	protein interactions	56961	17	1	19454	50	ERBB4
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	50	APOE
4.282e-02	-3.15	KRTAP19-3 (keratin associated protein 19-3)	protein interactions	337970	17	1	19454	50	CAMK2G
4.282e-02	-3.15	FAM163B (family with sequence similarity 163 member B)	protein interactions	642968	17	1	19454	50	CAMK2G
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.296e-02	-3.15	phospholipid binding	molecular function	GO:0005543	489	4	18094	49	APOE,PLCB1,PITPNC1,PARD3
4.299e-02	-3.15	regulation of nervous system process	biological process	GO:0031644	120	2	18204	50	PARD3,NRXN1
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	50	APOE
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.307e-02	-3.14	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	50	APOE
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	response to ether	biological process	GO:0045472	16	1	18204	50	PLCB1
4.307e-02	-3.14	neuron cell-cell adhesion	biological process	GO:0007158	16	1	18204	50	NRXN1
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.311e-02	-3.14	human chr2q34	chromosome location	human chr2q34	23	1	26134	50	ERBB4
4.311e-02	-3.14	Lysophosphatidic Acid LPA5 Signalling	SMPDB pathways	SMP0063757	10	1	1369	6	PLCB1
4.311e-02	-3.14	Lysophosphatidic Acid LPA4 Signalling	SMPDB pathways	SMP0063756	10	1	1369	6	PLCB1
4.311e-02	-3.14	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	6	ADCY2
4.319e-02	-3.14	SH3	prosite domains	PS50002	222	3	12186	43	NEBL,MACF1,SORBS1
4.321e-02	-3.14	CARM1 (coactivator associated arginine methyltransferase 1)	protein interactions	10498	304	3	19454	50	RORA,CAMK2G,DTNA
4.333e-02	-3.14	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	43	NTRK2,ERBB4
4.358e-02	-3.13	protein complex involved in cell-matrix adhesion	cellular component	GO:0098637	17	1	19108	50	TNC
4.358e-02	-3.13	apical dendrite	cellular component	GO:0097440	17	1	19108	50	CLU
4.370e-02	-3.13	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	2	10285	34	GPC5,APOE
4.381e-02	-3.13	TYRKINASE	prints domains	PR00109	98	2	5227	18	ERBB4,NTRK2
4.423e-02	-3.12	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	5	16828	48	PARD3,LRP1B,NRXN1,MACF1,NRG3
4.423e-02	-3.12	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	5	16828	48	MACF1,NRG3,NRXN1,LRP1B,PARD3
4.424e-02	-3.12	Ig-like_fold	interpro domains	IPR013783	721	5	18521	50	TNC,LSAMP,NTRK2,NTM,CNTN1
4.426e-02	-3.12	neuron projection terminus	cellular component	GO:0044306	128	2	19108	50	SLC1A2,NTRK2
4.432e-02	-3.12	negative regulation of cellular component organization	biological process	GO:0051129	709	5	18204	50	CST3,CLU,CTNNA2,GFAP,APOE
4.451e-02	-3.11	identical protein binding	molecular function	GO:0042802	2043	10	18094	49	PLCB1,ERBB4,SLC4A4,NTRK2,CST3,MSI2,APOE,PRKG1,GFAP,CAMK2G
4.453e-02	-3.11	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	45	16828	48	NRXN1,NKAIN3,TNC,SLC1A2,GLIS3,NAV2,ERBB4,TNIK,PLCB1,LRP1B,PITPNC1,ATP1A2,MACF1,HPSE2,CLU,LSAMP,RORA,RFX4,NRG3,DTNA,CAMK2G,GPC5,NTM,PRKG1,NEBL,NTRK2,CNTN1,DGKG,RYR3,SORBS1,FMN2,GPM6A,GFAP,MGAT4C,TRPM3,SLC4A4,SOX5,ABLIM1,SLC14A1,DCLK2,CTNND2,NPAS3,PARD3,ADCY2,CDH20
4.475e-02	-3.11	positive regulation of macromolecule biosynthetic process	biological process	GO:0010557	2592	12	18204	50	CNTN1,ERBB4,TNC,GLIS3,NTRK2,NPAS3,PLCB1,SORBS1,CLU,RFX4,APOE,RORA
4.476e-02	-3.11	FBXO22 (F-box protein 22)	protein interactions	26263	522	4	19454	50	SORBS1,RYR3,NAV2,APOE
4.492e-02	-3.10	muscle cell differentiation	biological process	GO:0042692	289	3	18204	50	NEBL,RORA,PRKG1
4.493e-02	-3.10	ATP-NAD_kinase_N	interpro domains	IPR017438	17	1	18521	50	DGKG
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY2
4.493e-02	-3.10	Cystatin_dom	interpro domains	IPR000010	17	1	18521	50	CST3
4.493e-02	-3.10	NAD/diacylglycerol_kinase_sf	interpro domains	IPR016064	17	1	18521	50	DGKG
4.493e-02	-3.10	PLipase_C_PInositol-sp_X_dom	interpro domains	IPR000909	17	1	18521	50	PLCB1
4.494e-02	-3.10	LDLRB	prosite domains	PS51120	13	1	12186	43	LRP1B
4.499e-02	-3.10	ITCH (itchy E3 ubiquitin protein ligase)	protein interactions	83737	309	3	19454	50	RORA,ERBB4,GLIS3
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	ZNF224 (zinc finger protein 224)	protein interactions	7767	18	1	19454	50	LRP1B
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKG1
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	PARD3
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	50	APOE
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.529e-02	-3.09	ADAT2 (adenosine deaminase tRNA specific 2)	protein interactions	134637	18	1	19454	50	NAV2
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.530e-02	-3.09	STRN (striatin)	protein interactions	6801	132	2	19454	50	TNIK,CAMK2G
4.533e-02	-3.09	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	34	ABLIM1
4.551e-02	-3.09	Z disc	cellular component	GO:0030018	130	2	19108	50	NEBL,RYR3
4.560e-02	-3.09	cardiocyte differentiation	biological process	GO:0035051	124	2	18204	50	PRKG1,NEBL
4.560e-02	-3.09	positive regulation of lipid metabolic process	biological process	GO:0045834	124	2	18204	50	APOE,SORBS1
4.560e-02	-3.09	action potential	biological process	GO:0001508	124	2	18204	50	ATP1A2,NTRK2
4.567e-02	-3.09	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	45	FMN2
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	TNIK
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	50	NTRK2
4.570e-02	-3.09	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	50	RORA
4.570e-02	-3.09	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	50	APOE
4.570e-02	-3.09	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	50	ATP1A2
4.570e-02	-3.09	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	50	APOE
4.570e-02	-3.09	positive regulation of meiotic nuclear division	biological process	GO:0045836	17	1	18204	50	PLCB1
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	cGMP metabolic process	biological process	GO:0046068	17	1	18204	50	RORA
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	50	APOE
4.570e-02	-3.09	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	50	CTNNA2
4.570e-02	-3.09	branch elongation of an epithelium	biological process	GO:0060602	17	1	18204	50	TNC
4.570e-02	-3.09	preganglionic parasympathetic fiber development	biological process	GO:0021783	17	1	18204	50	NAV2
4.570e-02	-3.09	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	50	CLU
4.570e-02	-3.09	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	50	SORBS1
4.570e-02	-3.09	regulation of fertilization	biological process	GO:0080154	17	1	18204	50	PLCB1
4.570e-02	-3.09	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	50	ERBB4
4.570e-02	-3.09	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	50	APOE
4.579e-02	-3.08	signaling receptor binding	molecular function	GO:0005102	1493	8	18094	49	GFAP,APOE,NRG3,NRXN1,SORBS1,TNC,CLU,ERBB4
4.581e-02	-3.08	Cystatin	pfam domains	PF00031	17	1	17795	49	CST3
4.581e-02	-3.08	PI-PLC-X	pfam domains	PF00388	17	1	17795	49	PLCB1
4.581e-02	-3.08	ZZ	pfam domains	PF00569	17	1	17795	49	DTNA
4.598e-02	-3.08	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	48	CTNND2,FMN2
4.606e-02	-3.08	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	34	RYR3,TRPM3
4.626e-02	-3.07	actomyosin structure organization	biological process	GO:0031032	125	2	18204	50	SORBS1,NEBL
4.626e-02	-3.07	cellular component assembly involved in morphogenesis	biological process	GO:0010927	125	2	18204	50	NEBL,CNTN1
4.626e-02	-3.07	memory	biological process	GO:0007613	125	2	18204	50	PLCB1,APOE
4.626e-02	-3.07	cerebral cortex development	biological process	GO:0021987	125	2	18204	50	PLCB1,NTRK2
4.626e-02	-3.07	mammary gland development	biological process	GO:0030879	125	2	18204	50	NRG3,ERBB4
4.626e-02	-3.07	cellular anatomical entity morphogenesis	biological process	GO:0032989	125	2	18204	50	CNTN1,NEBL
4.627e-02	-3.07	basal part of cell	cellular component	GO:0045178	307	3	19108	50	SLC14A1,ERBB4,SLC4A4
4.642e-02	-3.07	extracellular region	cellular component	GO:0005576	4350	17	19108	50	GPC5,HPSE2,APOE,GPM6A,NEBL,TNIK,SLC4A4,CST3,ERBB4,TNC,ATP1A2,PLCB1,CNTN1,LSAMP,NTM,NRG3,CLU
4.647e-02	-3.07	SOS-mediated signalling	REACTOME pathways	R-HSA-112412	245	3	10285	34	NRG3,ERBB4,CAMK2G
4.647e-02	-3.07	SHC1 events in EGFR signaling	REACTOME pathways	R-HSA-180336	245	3	10285	34	CAMK2G,ERBB4,NRG3
4.647e-02	-3.07	GRB2 events in EGFR signaling	REACTOME pathways	R-HSA-179812	245	3	10285	34	ERBB4,NRG3,CAMK2G
4.647e-02	-3.07	RAF/MAP kinase cascade	REACTOME pathways	R-HSA-5673001	245	3	10285	34	CAMK2G,NRG3,ERBB4
4.653e-02	-3.07	EGFR (epidermal growth factor receptor)	protein interactions	1956	3105	13	19454	50	CLU,PARD3,SORBS1,CTNNA2,NTRK2,ABLIM1,CTNND2,DTNA,CAMK2G,ERBB4,TNC,TRPM3,TNIK
4.654e-02	-3.07	channel activity	molecular function	GO:0015267	502	4	18094	49	GPM6A,RYR3,SLC14A1,TRPM3
4.667e-02	-3.06	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	48	DTNA,CDH20
4.677e-02	-3.06	human chr20p12.3	chromosome location	human chr20p12.3	25	1	26134	50	PLCB1
4.682e-02	-3.06	passive transmembrane transporter activity	molecular function	GO:0022803	503	4	18094	49	RYR3,GPM6A,SLC14A1,TRPM3
4.693e-02	-3.06	limbic system development	biological process	GO:0021761	126	2	18204	50	DCLK2,ATP1A2
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	CAMK2G,ABLIM1
4.725e-02	-3.05	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	3	18204	50	NTRK2,ERBB4,APOE
4.734e-02	-3.05	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	6	RORA
4.746e-02	-3.05	regulation of anatomical structure size	biological process	GO:0090066	498	4	18204	50	ATP1A2,APOE,PRKG1,MACF1
4.746e-02	-3.05	Growth_fac_rcpt_cys_sf	interpro domains	IPR009030	129	2	18521	50	LRP1B,ERBB4
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY2
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY2
4.752e-02	-3.05	Furin_repeat	interpro domains	IPR006212	18	1	18521	50	ERBB4
4.752e-02	-3.05	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	1	18521	50	ATP1A2
4.760e-02	-3.05	negative regulation of neuron projection development	biological process	GO:0010977	127	2	18204	50	GFAP,APOE
4.760e-02	-3.05	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	50	PARD3,CDH20
4.760e-02	-3.05	response to amino acid	biological process	GO:0043200	127	2	18204	50	NTRK2,SLC1A2
4.766e-02	-3.04	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	1	18094	49	SLC1A2
4.766e-02	-3.04	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	49	PITPNC1
4.766e-02	-3.04	lipoprotein particle receptor activity	molecular function	GO:0030228	18	1	18094	49	LRP1B
4.766e-02	-3.04	GABA receptor binding	molecular function	GO:0050811	18	1	18094	49	ERBB4
4.766e-02	-3.04	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	49	RYR3
4.766e-02	-3.04	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	49	NRG3
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	CNTN1
4.774e-02	-3.04	HBEGF (heparin binding EGF like growth factor)	protein interactions	1839	19	1	19454	50	ERBB4
4.774e-02	-3.04	RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)	protein interactions	6236	19	1	19454	50	CAMK2G
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	ZNF532 (zinc finger protein 532)	protein interactions	55205	19	1	19454	50	ERBB4
4.774e-02	-3.04	LTC4S (leukotriene C4 synthase)	protein interactions	4056	19	1	19454	50	CAMK2G
4.774e-02	-3.04	Trp53 (transformation related protein 53)	protein interactions	22059	19	1	19454	50	MAPK10
4.774e-02	-3.04	EGFL6 (EGF like domain multiple 6)	protein interactions	25975	19	1	19454	50	LRP1B
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	NLGN1 (neuroligin 1)	protein interactions	22871	19	1	19454	50	NRXN1
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	PLCB2 (phospholipase C beta 2)	protein interactions	5330	19	1	19454	50	PLCB1
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	Mtx1 (metaxin 1)	protein interactions	17827	19	1	19454	50	CAMK2G
4.774e-02	-3.04	PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2)	protein interactions	57546	19	1	19454	50	GFAP
4.774e-02	-3.04	SYT7 (synaptotagmin 7)	protein interactions	9066	19	1	19454	50	NRXN1
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	KCNF1 (potassium voltage-gated channel modifier subfamily F member 1)	protein interactions	3754	19	1	19454	50	GFAP
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.776e-02	-3.04	Proteoglycans in cancer	KEGG pathways	ko05205	203	3	7161	29	CAMK2G,HPSE2,ERBB4
4.776e-02	-3.04	Proteoglycans in cancer	KEGG pathways	hsa05205	203	3	7161	29	CAMK2G,HPSE2,ERBB4
4.782e-02	-3.04	regulation of multicellular organismal development	biological process	GO:2000026	1484	8	18204	50	MACF1,PARD3,SOX5,ERBB4,GFAP,PLCB1,NTRK2,NRXN1
4.802e-02	-3.04	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	48	16828	48	SLC14A1,DCLK2,TRPM3,ABLIM1,SLC4A4,SOX5,CDH20,ADCY2,NPAS3,CTNND2,PARD3,DGKG,MSI2,CNTN1,NTRK2,MGAT4C,RYR3,GFAP,FMN2,GPM6A,SORBS1,NRG3,RFX4,CST3,HPSE2,MACF1,RORA,CLU,LSAMP,NEBL,GPC5,DTNA,CAMK2G,PRKG1,NTM,GLIS3,ERBB4,NAV2,NRXN1,SLC1A2,TNC,APOE,NKAIN3,ATP1A2,PITPNC1,LRP1B,PLCB1,TNIK
4.822e-02	-3.03	cell population proliferation	biological process	GO:0008283	726	5	18204	50	GFAP,RORA,CLU,HPSE2,SOX5
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.832e-02	-3.03	regulation of establishment of endothelial barrier	biological process	GO:1903140	18	1	18204	50	PLCB1
4.832e-02	-3.03	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	50	NEBL
4.832e-02	-3.03	response to misfolded protein	biological process	GO:0051788	18	1	18204	50	CLU
4.832e-02	-3.03	positive regulation of myelination	biological process	GO:0031643	18	1	18204	50	PARD3
4.832e-02	-3.03	myelin maintenance	biological process	GO:0043217	18	1	18204	50	CLU
4.832e-02	-3.03	regulation of endothelial cell development	biological process	GO:1901550	18	1	18204	50	PLCB1
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	regulation of protein kinase C signaling	biological process	GO:0090036	18	1	18204	50	DGKG
4.832e-02	-3.03	regulation of acrosome reaction	biological process	GO:0060046	18	1	18204	50	PLCB1
4.832e-02	-3.03	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	50	NTRK2
4.832e-02	-3.03	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	50	CST3
4.836e-02	-3.03	Signalling to p38 via RIT and RIN	REACTOME pathways	R-HSA-187706	249	3	10285	34	NRG3,ERBB4,CAMK2G
4.836e-02	-3.03	ARMS-mediated activation	REACTOME pathways	R-HSA-170984	249	3	10285	34	NRG3,ERBB4,CAMK2G
4.842e-02	-3.03	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	2	19454	50	DGKG,SOX5
4.843e-02	-3.03	ASX_HYDROXYL	prosite domains	PS00010	100	2	12186	43	LRP1B,NRXN1
4.844e-02	-3.03	Cation_ATPase_N	pfam domains	PF00690	18	1	17795	49	ATP1A2
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY2
4.848e-02	-3.03	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	2	10285	34	SLC1A2,SLC4A4
4.849e-02	-3.03	N-Glycan antennae elongation	REACTOME pathways	R-HSA-975577	15	1	10285	34	MGAT4C
4.849e-02	-3.03	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	34	ADCY2
4.849e-02	-3.03	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	34	ADCY2
4.859e-02	-3.02	cytosolic region	cellular component	GO:0099522	19	1	19108	50	PLCB1
4.859e-02	-3.02	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	50	TNIK
4.859e-02	-3.02	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	50	GPM6A
4.859e-02	-3.02	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	50	ATP1A2
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.865e-02	-3.02	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	22	RYR3
4.884e-02	-3.02	Frs2-mediated activation	REACTOME pathways	R-HSA-170968	250	3	10285	34	NRG3,ERBB4,CAMK2G
4.906e-02	-3.01	FXR1 (FMR1 autosomal homolog 1)	protein interactions	8087	538	4	19454	50	CLU,CAMK2G,GFAP,SOX5
4.921e-02	-3.01	cellular response to hormone stimulus	biological process	GO:0032870	504	4	18204	50	SORBS1,ATP1A2,PLCB1,TNC
4.932e-02	-3.01	MAPK1/MAPK3 signaling	REACTOME pathways	R-HSA-5684996	251	3	10285	34	CAMK2G,ERBB4,NRG3
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	SORBS1,MACF1,DTNA
4.946e-02	-3.01	knee	COSMIC cancer mutations	knee	125	2	16828	48	CNTN1,ERBB4
4.951e-02	-3.01	monoatomic cation homeostasis	biological process	GO:0055080	505	4	18204	50	SLC4A4,ATP1A2,APOE,RYR3
4.951e-02	-3.01	cellular response to organonitrogen compound	biological process	GO:0071417	505	4	18204	50	SORBS1,RYR3,SLC1A2,PLCB1
4.968e-02	-3.00	SPCS2 (signal peptidase complex subunit 2)	protein interactions	9789	139	2	19454	50	MGAT4C,GPC5
4.980e-02	-3.00	Prolonged ERK activation events	REACTOME pathways	R-HSA-169893	252	3	10285	34	NRG3,ERBB4,CAMK2G
4.983e-02	-3.00	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	49	NTRK2,ERBB4