Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
6.687e-12	-25.73	nervous system development	biological process	GO:0007399	2185	26	18204	50	LSAMP,RFX4,PRKG1,NRG3,TNIK,CNTN1,NTM,DCLK2,RORA,CTNND2,PARD3,ATP1A2,SOX5,APOE,MSI2,CLU,NFIA,ERBB4,SLC1A3,GJA1,SLC1A2,GPM6A,NTRK2,TNC,CTNNA2,DGKG
7.335e-11	-23.34	generation of neurons	biological process	GO:0048699	1158	19	18204	50	DGKG,CTNNA2,TNC,PARD3,APOE,SOX5,PRKG1,GJA1,ERBB4,SLC1A3,NFIA,CTNND2,NTRK2,DCLK2,RORA,CNTN1,TNIK,NTM,GPM6A
9.732e-11	-23.05	neurogenesis	biological process	GO:0022008	1334	20	18204	50	PRKG1,GJA1,ERBB4,SLC1A3,NFIA,CLU,NTRK2,CTNND2,RORA,DCLK2,NTM,CNTN1,TNIK,GPM6A,DGKG,CTNNA2,TNC,PARD3,APOE,SOX5
1.320e-09	-20.45	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	18	16828	48	PRKG1,NPAS3,TNIK,HPSE2,ATP1A2,DCLK2,NTRK2,SLC1A2,ERBB4,LSAMP,NRG3,NFIA,RYR3,PARD3,SOX5,NKAIN3,ADCY2,LRP1B
1.320e-09	-20.45	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	18	16828	48	SLC1A2,NTRK2,DCLK2,ATP1A2,HPSE2,TNIK,NPAS3,PRKG1,LRP1B,ADCY2,NKAIN3,SOX5,PARD3,NFIA,RYR3,NRG3,LSAMP,ERBB4
1.896e-09	-20.08	cell periphery	cellular component	GO:0071944	6020	36	19108	49	SLC1A2,DTNA,CDH20,DGKG,PARD3,LSAMP,CTNND2,TNC,MAPK10,TNIK,APOE,RYR3,CTNNA2,NTRK2,CNTN1,ATP1A2,HPSE2,CLU,GJA1,NKAIN3,GPM6A,PRKG1,SLC1A3,ADCY2,FMN2,SORBS1,GPC5,AQP4,NTM,NRG3,CST3,ERBB4,SLC14A1,LRP1B,MACF1,TRPM3
1.910e-09	-20.08	neuron differentiation	biological process	GO:0030182	1081	17	18204	50	DCLK2,RORA,CTNND2,NTRK2,GPM6A,TNIK,NTM,CNTN1,PRKG1,NFIA,SLC1A3,ERBB4,APOE,CTNNA2,DGKG,PARD3,TNC
2.339e-09	-19.87	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	23	16828	48	NRG3,RYR3,SLC1A3,DGKG,ERBB4,LRP1B,GPM6A,SOX5,NPAS3,PRKG1,HPSE2,SLC1A2,NTRK2,RFX4,CTNND2,LSAMP,NHSL1,ADCY2,CNTN1,PARD3,NKAIN3,GPC5,FMN2
2.339e-09	-19.87	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	23	16828	48	RFX4,CTNND2,LSAMP,PARD3,NKAIN3,NHSL1,ADCY2,CNTN1,GPC5,FMN2,ERBB4,DGKG,SLC1A3,NRG3,RYR3,SOX5,GPM6A,LRP1B,NPAS3,PRKG1,HPSE2,NTRK2,SLC1A2
5.511e-09	-19.02	plasma membrane	cellular component	GO:0005886	5538	34	19108	49	DTNA,SLC1A2,CDH20,DGKG,PARD3,CTNND2,LSAMP,MAPK10,TNIK,RYR3,APOE,NTRK2,CTNNA2,CNTN1,HPSE2,GJA1,ATP1A2,PRKG1,GPM6A,NKAIN3,SLC1A3,ADCY2,SORBS1,GPC5,FMN2,NTM,AQP4,NRG3,ERBB4,CST3,SLC14A1,TRPM3,MACF1,LRP1B
5.608e-09	-19.00	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	31	16828	48	SLC1A2,TRPS1,NTRK2,NEBL,AQP4,PRKG1,HPSE2,TNIK,LRP1B,GPM6A,RORA,MACF1,TNC,SOX5,RYR3,NRG3,CLU,ERBB4,DGKG,SLC1A3,FMN2,ATP1A2,GPC5,DTNA,ADCY2,CNTN1,PARD3,NKAIN3,LSAMP,CTNND2,CDH20
9.808e-09	-18.44	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	16	19454	50	CNTN1,TRPM3,TNC,APOE,NHSL1,SORBS1,LSAMP,TRPS1,MACF1,SLC1A3,CLU,GJA1,AQP4,ATP1A2,GPM6A,MSI2
1.026e-08	-18.39	system development	biological process	GO:0048731	3533	28	18204	50	NFIA,NEBL,CLU,SLC1A3,ERBB4,GJA1,SLC1A2,GPM6A,NTRK2,TNC,DGKG,CTNNA2,LSAMP,NRG3,PRKG1,RFX4,TNIK,NTM,CNTN1,TRPS1,RORA,DCLK2,CTNND2,PARD3,ATP1A2,SOX5,APOE,MSI2
1.199e-08	-18.24	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	19	16828	48	PRKG1,NEBL,HPSE2,GPC5,NTRK2,FMN2,ERBB4,DGKG,SLC1A3,LSAMP,CTNND2,RYR3,NRG3,RORA,PARD3,SOX5,NKAIN3,ADCY2,LRP1B
1.199e-08	-18.24	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	19	16828	48	NTRK2,FMN2,PRKG1,NEBL,HPSE2,GPC5,PARD3,RORA,SOX5,NKAIN3,ADCY2,LRP1B,DGKG,ERBB4,SLC1A3,CTNND2,LSAMP,RYR3,NRG3
1.608e-08	-17.95	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	14	16828	48	GPC5,HPSE2,SLC1A2,NTRK2,ATP1A2,RYR3,NRG3,LSAMP,ERBB4,LRP1B,ADCY2,NKAIN3,SOX5,PARD3
2.266e-08	-17.60	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	12	16828	48	RYR3,NRG3,LSAMP,CTNND2,NKAIN3,SOX5,LRP1B,GPM6A,ADCY2,PRKG1,GPC5,FMN2
2.762e-08	-17.40	multicellular organism development	biological process	GO:0007275	3957	29	18204	50	GJA1,NFIA,NEBL,CLU,SLC1A3,ERBB4,NTRK2,SLC1A2,GPM6A,DGKG,CTNNA2,TNC,LSAMP,RFX4,PRKG1,NRG3,DCLK2,RORA,CTNND2,CNTN1,TNIK,NTM,TRPS1,PARD3,SOX5,CDH20,MSI2,APOE,ATP1A2
4.684e-08	-16.88	neuron development	biological process	GO:0048666	859	14	18204	50	TNC,PARD3,DGKG,CTNNA2,APOE,SLC1A3,PRKG1,CNTN1,TNIK,NTM,GPM6A,NTRK2,CTNND2,DCLK2
7.021e-08	-16.47	MAPT (microtubule associated protein tau)	protein interactions	4137	948	14	19454	50	CTNNA2,NEBL,NTM,SLC1A2,CLU,MAPK10,ATP1A2,GPM6A,CTNND2,APOE,LSAMP,SORBS1,SLC1A3,TNIK
8.476e-08	-16.28	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	43	16828	48	ERBB4,RYR3,NRG3,TNC,MACF1,GLIS3,LRP1B,NPAS3,PRKG1,TNIK,TRPS1,NTRK2,DCLK2,LSAMP,CDH20,PARD3,NKAIN3,SORBS1,NHSL1,ADCY2,ZBTB20,GPC5,TRPM3,DTNA,PITPNC1,SLC1A3,DGKG,CLU,RORA,MSI2,SOX5,APOE,NTM,GPM6A,NEBL,HPSE2,SLC14A1,SLC1A2,RFX4,CTNND2,NFIA,CNTN1,FMN2
1.127e-07	-16.00	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	28	16828	48	GPC5,ZBTB20,FMN2,NFIA,LSAMP,CTNND2,CNTN1,ADCY2,NKAIN3,PARD3,HPSE2,TNIK,NEBL,PRKG1,MGAT4C,SLC1A2,NTRK2,RYR3,NRG3,SLC1A3,ERBB4,NTM,GPM6A,LRP1B,GLIS3,SOX5,RORA,TNC
1.127e-07	-16.00	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	28	16828	48	CTNND2,LSAMP,NFIA,ADCY2,CNTN1,PARD3,NKAIN3,GPC5,ZBTB20,FMN2,RYR3,NRG3,ERBB4,SLC1A3,GLIS3,LRP1B,GPM6A,NTM,RORA,TNC,SOX5,PRKG1,NEBL,TNIK,HPSE2,SLC1A2,MGAT4C,NTRK2
1.308e-07	-15.85	cell development	biological process	GO:0048468	2236	21	18204	50	FMN2,GJA1,PRKG1,NEBL,CLU,SLC1A3,ERBB4,DCLK2,RORA,CTNND2,NTRK2,NTM,CNTN1,TNIK,GPM6A,DGKG,CTNNA2,PARD3,TNC,MSI2,APOE
1.359e-07	-15.81	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	24	16828	48	FMN2,TRPM3,GPC5,CNTN1,ADCY2,NKAIN3,PARD3,RFX4,LSAMP,CTNND2,SLC1A2,NTRK2,TRPS1,HPSE2,NEBL,PRKG1,LRP1B,GPM6A,SOX5,TNC,RYR3,NRG3,SLC1A3,ERBB4
1.471e-07	-15.73	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	27	16828	48	GPC5,FMN2,ATP1A2,LSAMP,CTNND2,CDH20,ADCY2,CNTN1,PARD3,NKAIN3,AQP4,NEBL,PRKG1,HPSE2,TNIK,SLC1A2,RYR3,NRG3,CLU,ERBB4,DGKG,GPM6A,LRP1B,TNC,MACF1,RORA,SOX5
1.594e-07	-15.65	cell junction organization	biological process	GO:0034330	532	11	18204	50	NFIA,PARD3,ERBB4,TNC,GJA1,SORBS1,NRG3,GPM6A,CDH20,APOE,CTNND2
1.762e-07	-15.55	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	34	16828	48	ATP1A2,FMN2,GPC5,TRPM3,DTNA,PARD3,NKAIN3,SORBS1,ADCY2,CNTN1,LSAMP,CTNND2,CDH20,TRPS1,NTRK2,MGAT4C,NEBL,NPAS3,PRKG1,HPSE2,SLC14A1,CST3,MACF1,TNC,SOX5,NTM,GPM6A,LRP1B,DGKG,SLC1A3,ERBB4,NRG3,RYR3,CLU
1.762e-07	-15.55	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	34	16828	48	CNTN1,ADCY2,SORBS1,NKAIN3,PARD3,CDH20,CTNND2,LSAMP,FMN2,ATP1A2,DTNA,TRPM3,GPC5,LRP1B,GPM6A,NTM,SOX5,MACF1,TNC,CLU,RYR3,NRG3,DGKG,SLC1A3,ERBB4,MGAT4C,NTRK2,TRPS1,CST3,SLC14A1,HPSE2,PRKG1,NPAS3,NEBL
1.885e-07	-15.48	cell junction	cellular component	GO:0030054	2224	20	19108	49	NFIA,CTNND2,SLC1A3,TNC,SLC1A2,DTNA,CDH20,CLU,GJA1,ATP1A2,GPM6A,PARD3,NTRK2,ERBB4,CTNNA2,CNTN1,SORBS1,TNIK,NRG3,APOE
3.141e-07	-14.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	23	16828	48	TNC,PARD3,NKAIN3,SOX5,ADCY2,CNTN1,LRP1B,GPM6A,SLC1A3,ERBB4,RFX4,LSAMP,CTNND2,NRG3,RYR3,TRPS1,NTRK2,FMN2,SLC1A2,NEBL,PRKG1,HPSE2,GPC5
3.347e-07	-14.91	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	34	16828	48	ERBB4,SLC1A3,NRG3,RYR3,CLU,APOE,SOX5,TNC,MACF1,RORA,LRP1B,GPM6A,GLIS3,HPSE2,NPAS3,NEBL,AQP4,PRKG1,NTRK2,TRPS1,SLC1A2,NFIA,CDH20,CTNND2,LSAMP,NKAIN3,SORBS1,PARD3,NHSL1,ADCY2,GJA1,GPC5,TRPM3,FMN2
4.239e-07	-14.67	lymph_node	COSMIC cancer mutations	lymph_node	1703	18	16828	48	SLC1A3,ERBB4,LSAMP,CTNND2,NRG3,RYR3,PARD3,SOX5,GPM6A,LRP1B,NEBL,PRKG1,TNIK,TRPM3,GPC5,DTNA,TRPS1,NTRK2
6.193e-07	-14.29	anatomical structure morphogenesis	biological process	GO:0009653	2225	20	18204	50	APOE,SOX5,CDH20,CTNNA2,TNC,PARD3,CTNND2,NTRK2,RORA,CNTN1,TNIK,GPM6A,PRKG1,NRG3,GJA1,ERBB4,SLC1A3,NFIA,NEBL,CLU
6.984e-07	-14.17	brainstem	COSMIC cancer mutations	brainstem	3102	24	16828	48	ERBB4,SLC1A3,RYR3,NRG3,SOX5,TNC,RORA,LRP1B,GPM6A,HPSE2,TNIK,NPAS3,PRKG1,SLC14A1,SLC1A2,CDH20,LSAMP,CTNND2,NKAIN3,PARD3,ADCY2,ZBTB20,GPC5,FMN2
7.439e-07	-14.11	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	10	16828	48	LSAMP,CTNND2,GPC5,TRPM3,RYR3,NRG3,PRKG1,ERBB4,GPM6A,LRP1B
7.886e-07	-14.05	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	20	16828	48	LRP1B,GPM6A,ADCY2,NKAIN3,SOX5,PARD3,NRG3,RYR3,CDH20,LSAMP,CTNND2,SLC1A3,ERBB4,FMN2,SLC1A2,NTRK2,GPC5,HPSE2,NEBL,PRKG1
7.886e-07	-14.05	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	20	16828	48	ADCY2,GPM6A,LRP1B,PARD3,SOX5,NKAIN3,CTNND2,LSAMP,CDH20,NRG3,RYR3,SLC1A3,ERBB4,SLC1A2,FMN2,NTRK2,GPC5,PRKG1,NEBL,HPSE2
9.065e-07	-13.91	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	20	16828	48	GPC5,NEBL,PRKG1,HPSE2,FMN2,SLC1A2,NTRK2,CTNND2,LSAMP,RYR3,NRG3,CDH20,SLC1A3,ERBB4,ADCY2,LRP1B,GPM6A,PARD3,NKAIN3,SOX5
1.162e-06	-13.67	cerebellum	COSMIC cancer mutations	cerebellum	769	12	16828	48	NRG3,RYR3,GPC5,CTNND2,HPSE2,NEBL,NPAS3,PRKG1,ERBB4,LRP1B,NTRK2,PARD3
1.278e-06	-13.57	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	15	16828	48	NRG3,RYR3,CTNND2,LRP1B,GPM6A,NTM,ADCY2,TNC,MACF1,TNIK,HPSE2,NEBL,FMN2,NTRK2,TRPS1
1.278e-06	-13.57	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	15	16828	48	NEBL,HPSE2,TNIK,TRPS1,NTRK2,FMN2,CTNND2,RYR3,NRG3,TNC,MACF1,ADCY2,NTM,GPM6A,LRP1B
1.623e-06	-13.33	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	8	19454	50	NEBL,PARD3,CTNNA2,TNIK,MACF1,DTNA,NHSL1,SORBS1
1.683e-06	-13.29	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	11	16828	48	HPSE2,NPAS3,NEBL,PRKG1,NTRK2,RYR3,NRG3,CTNND2,ERBB4,LRP1B,PARD3
1.709e-06	-13.28	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	11	16828	48	RYR3,NRG3,CTNND2,HPSE2,NEBL,NPAS3,ERBB4,PRKG1,LRP1B,NTRK2,PARD3
1.759e-06	-13.25	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	21	16828	48	FMN2,SLC14A1,GPC5,PRKG1,HPSE2,ZBTB20,TNIK,ADCY2,LRP1B,GPM6A,RORA,PARD3,NKAIN3,SOX5,LSAMP,CTNND2,RYR3,NRG3,CDH20,SLC1A3,ERBB4
1.926e-06	-13.16	central nervous system development	biological process	GO:0007417	995	13	18204	50	NRG3,RFX4,PRKG1,ERBB4,CLU,NTRK2,RORA,DCLK2,CNTN1,SLC1A2,CTNNA2,MSI2,ATP1A2
1.935e-06	-13.16	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	8	16828	48	LRP1B,GPM6A,FMN2,ADCY2,SOX5,NKAIN3,GPC5,PRKG1
1.990e-06	-13.13	cell morphogenesis	biological process	GO:0000902	687	11	18204	50	CTNND2,CDH20,GPM6A,TNIK,CNTN1,CTNNA2,PRKG1,SLC1A3,CLU,NFIA,PARD3
3.021e-06	-12.71	mouth	COSMIC cancer mutations	mouth	9004	41	16828	48	ATP1A2,FMN2,ZBTB20,DTNA,GPC5,TRPM3,PITPNC1,PARD3,SORBS1,ADCY2,NHSL1,CNTN1,CTNND2,LSAMP,RFX4,CDH20,TRPS1,DCLK2,NTRK2,SLC1A2,MGAT4C,PRKG1,NPAS3,NEBL,TNIK,HPSE2,CST3,RORA,MACF1,TNC,SOX5,APOE,GPM6A,LRP1B,NTM,DGKG,ERBB4,SLC1A3,CLU,NRG3,RYR3
3.302e-06	-12.62	brain development	biological process	GO:0007420	724	11	18204	50	SLC1A2,CNTN1,DCLK2,RORA,NTRK2,ERBB4,PRKG1,RFX4,NRG3,ATP1A2,CTNNA2
3.560e-06	-12.55	anatomical structure development	biological process	GO:0048856	5207	30	18204	50	PARD3,ATP1A2,CDH20,SOX5,APOE,MSI2,LSAMP,FMN2,PRKG1,NRG3,RFX4,TRPS1,NTM,TNIK,CNTN1,RORA,DCLK2,CTNND2,TNC,CTNNA2,DGKG,CLU,NEBL,NFIA,SLC1A3,ERBB4,GJA1,SLC1A2,GPM6A,NTRK2
4.305e-06	-12.36	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	14	16828	48	HPSE2,TNIK,AQP4,PRKG1,GPC5,NKAIN3,SOX5,PARD3,RORA,LRP1B,ADCY2,NRG3,LSAMP,CTNND2
5.503e-06	-12.11	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	26	16828	48	ERBB4,DGKG,RYR3,TNC,MACF1,GLIS3,LRP1B,GPM6A,NEBL,NPAS3,AQP4,PRKG1,TNIK,TRPS1,NTRK2,SLC1A2,RFX4,CTNND2,NFIA,PARD3,NHSL1,ADCY2,GJA1,PITPNC1,ATP1A2,FMN2
5.917e-06	-12.04	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	36	16828	48	NRG3,RYR3,ERBB4,SLC1A3,DGKG,NTM,LRP1B,GPM6A,GLIS3,SOX5,MACF1,RORA,HPSE2,TNIK,NEBL,NPAS3,PRKG1,SLC1A2,NTRK2,DCLK2,TRPS1,NFIA,RFX4,LSAMP,CTNND2,CNTN1,NHSL1,ADCY2,NKAIN3,SORBS1,PARD3,PITPNC1,TRPM3,GPC5,ZBTB20,FMN2
6.102e-06	-12.01	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	7	16828	48	NRG3,NFIA,GPC5,HPSE2,ERBB4,NPAS3,ADCY2
6.102e-06	-12.01	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	7	16828	48	NFIA,NRG3,ADCY2,GPC5,HPSE2,ERBB4,NPAS3
6.254e-06	-11.98	head development	biological process	GO:0060322	774	11	18204	50	CTNNA2,ATP1A2,NRG3,RFX4,PRKG1,ERBB4,RORA,DCLK2,NTRK2,SLC1A2,CNTN1
6.387e-06	-11.96	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	36	16828	48	CLU,NRG3,RYR3,DGKG,ERBB4,LRP1B,NTM,SOX5,RORA,TNC,MACF1,CST3,SLC14A1,HPSE2,PRKG1,NEBL,AQP4,NPAS3,SLC1A2,DCLK2,NTRK2,TRPS1,CDH20,NFIA,LSAMP,CTNND2,RFX4,CNTN1,ADCY2,NHSL1,PARD3,PITPNC1,TRPM3,ZBTB20,FMN2,ATP1A2
6.387e-06	-11.96	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	36	16828	48	ERBB4,DGKG,NRG3,RYR3,CLU,RORA,MACF1,TNC,SOX5,NTM,LRP1B,NPAS3,AQP4,NEBL,PRKG1,HPSE2,SLC14A1,CST3,TRPS1,NTRK2,DCLK2,SLC1A2,RFX4,LSAMP,CTNND2,NFIA,CDH20,PARD3,NHSL1,ADCY2,CNTN1,ZBTB20,TRPM3,PITPNC1,ATP1A2,FMN2
6.905e-06	-11.88	acidic amino acid transport	biological process	GO:0015800	45	4	18204	50	SLC1A3,SLC1A2,NTRK2,GJA1
7.914e-06	-11.75	developmental process	biological process	GO:0032502	5716	31	18204	50	LSAMP,FMN2,PRKG1,RFX4,NRG3,TRPS1,CNTN1,TNIK,NTM,RORA,DCLK2,CTNND2,PARD3,ATP1A2,SOX5,CDH20,APOE,MSI2,CLU,NHSL1,NFIA,NEBL,ERBB4,SLC1A3,GJA1,SLC1A2,GPM6A,NTRK2,TNC,CTNNA2,DGKG
8.161e-06	-11.72	cell differentiation	biological process	GO:0030154	3645	24	18204	50	NTRK2,GPM6A,GJA1,ERBB4,SLC1A3,NEBL,NFIA,NHSL1,CLU,DGKG,CTNNA2,TNC,CTNND2,RORA,DCLK2,CNTN1,NTM,TNIK,PRKG1,FMN2,MSI2,APOE,SOX5,PARD3
8.282e-06	-11.70	cellular developmental process	biological process	GO:0048869	3648	24	18204	50	PARD3,APOE,MSI2,SOX5,PRKG1,FMN2,NTM,CNTN1,TNIK,CTNND2,RORA,DCLK2,TNC,CTNNA2,DGKG,SLC1A3,ERBB4,CLU,NHSL1,NFIA,NEBL,GJA1,GPM6A,NTRK2
8.486e-06	-11.68	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	5	16828	48	CTNND2,LSAMP,GPM6A,LRP1B,NKAIN3
8.945e-06	-11.62	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	35	16828	48	CNTN1,ADCY2,NHSL1,SORBS1,PARD3,CDH20,LSAMP,CTNND2,RFX4,FMN2,ATP1A2,PITPNC1,DTNA,TRPM3,GPC5,ZBTB20,LRP1B,GPM6A,NTM,SOX5,TNC,RORA,MACF1,RYR3,NRG3,ERBB4,DGKG,SLC1A2,MGAT4C,DCLK2,TRPS1,CST3,TNIK,PRKG1,NEBL
9.207e-06	-11.60	beta-catenin binding	molecular function	GO:0008013	107	5	18094	48	CDH20,GJA1,CTNNA2,RORA,CTNND2
9.764e-06	-11.54	telencephalon development	biological process	GO:0021537	276	7	18204	50	DCLK2,NTRK2,SLC1A2,ATP1A2,RFX4,NRG3,ERBB4
9.823e-06	-11.53	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	13	16828	48	PRKG1,GPC5,FMN2,SLC1A2,DGKG,ERBB4,RYR3,NRG3,CDH20,PARD3,SOX5,ADCY2,LRP1B
1.189e-05	-11.34	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	5	16828	48	PARD3,PRKG1,GPC5,NRG3,LRP1B
1.203e-05	-11.33	cell junction assembly	biological process	GO:0034329	285	7	18204	50	PARD3,ERBB4,SORBS1,GJA1,NRG3,GPM6A,CDH20
1.324e-05	-11.23	multicellular organismal process	biological process	GO:0032501	6177	32	18204	50	TRPS1,TNIK,NTM,CNTN1,RORA,DCLK2,CTNND2,DTNA,LSAMP,PRKG1,NRG3,RFX4,ATP1A2,CDH20,SOX5,MSI2,APOE,PARD3,SLC1A2,GPM6A,NTRK2,CLU,NEBL,NFIA,SLC1A3,ERBB4,GJA1,RYR3,AQP4,TNC,CTNNA2,DGKG
1.370e-05	-11.20	plasma membrane region	cellular component	GO:0098590	1278	13	19108	49	SLC1A3,SLC1A2,GJA1,ATP1A2,GPM6A,PARD3,ERBB4,SLC14A1,MACF1,CNTN1,SORBS1,TNIK,AQP4
1.381e-05	-11.19	adenoma	COSMIC cancer mutations	adenoma	2873	21	16828	48	NTRK2,DCLK2,GPC5,TRPM3,ZBTB20,HPSE2,NEBL,NPAS3,PRKG1,GPM6A,LRP1B,ADCY2,APOE,SOX5,PARD3,TNC,MACF1,RYR3,CDH20,CTNND2,ERBB4
1.400e-05	-11.18	forebrain development	biological process	GO:0030900	408	8	18204	50	NTRK2,DCLK2,ATP1A2,SLC1A2,NRG3,RFX4,PRKG1,ERBB4
1.423e-05	-11.16	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	12	16828	48	ADCY2,LRP1B,PARD3,RORA,SOX5,NKAIN3,CTNND2,LSAMP,GPC5,NRG3,PRKG1,HPSE2
1.498e-05	-11.11	Salivary secretion	KEGG pathways	ko04970	90	5	7161	26	CST3,RYR3,ADCY2,PRKG1,ATP1A2
1.498e-05	-11.11	Salivary secretion	KEGG pathways	hsa04970	90	5	7161	26	ATP1A2,PRKG1,ADCY2,CST3,RYR3
1.696e-05	-10.98	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	33	16828	48	TRPS1,MGAT4C,SLC1A2,HPSE2,NPAS3,PRKG1,APOE,SOX5,TNC,MACF1,RORA,NTM,LRP1B,GPM6A,ERBB4,DGKG,SLC1A3,RYR3,NRG3,CLU,FMN2,ZBTB20,PITPNC1,TRPM3,GPC5,SORBS1,PARD3,CNTN1,NHSL1,ADCY2,CDH20,RFX4,CTNND2
1.750e-05	-10.95	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	25	16828	48	PRKG1,NPAS3,NEBL,AQP4,TNIK,TRPS1,NTRK2,SLC1A2,DGKG,ERBB4,RYR3,MACF1,TNC,GLIS3,LRP1B,GPM6A,GJA1,PITPNC1,ATP1A2,FMN2,CTNND2,RFX4,NFIA,PARD3,ADCY2
1.758e-05	-10.95	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	25	16828	48	DGKG,ERBB4,RYR3,TNC,MACF1,GLIS3,LRP1B,GPM6A,PRKG1,AQP4,NPAS3,NEBL,TNIK,TRPS1,NTRK2,SLC1A2,CTNND2,RFX4,NFIA,PARD3,ADCY2,GJA1,PITPNC1,ATP1A2,FMN2
2.014e-05	-10.81	pharynx	COSMIC cancer mutations	pharynx	2696	20	16828	48	SLC1A2,FMN2,ATP1A2,NTRK2,PITPNC1,DTNA,GPC5,SLC14A1,NPAS3,LRP1B,NHSL1,SORBS1,MACF1,CLU,RYR3,NFIA,NRG3,CTNND2,RFX4,DGKG
2.022e-05	-10.81	humerus	COSMIC cancer mutations	humerus	546	9	16828	48	NEBL,PRKG1,NKAIN3,SOX5,GPC5,ADCY2,FMN2,GPM6A,LRP1B
2.112e-05	-10.77	neuron projection	cellular component	GO:0043005	1331	13	19108	49	CTNNA2,NTRK2,CNTN1,APOE,SLC1A3,CTNND2,ADCY2,ATP1A2,CLU,DTNA,SLC1A2,PARD3,GPM6A
2.622e-05	-10.55	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	23	16828	48	CTNND2,LSAMP,RYR3,NRG3,CLU,ERBB4,SLC1A3,ADCY2,LRP1B,PARD3,MACF1,MSI2,GPC5,TRPM3,DTNA,PITPNC1,NPAS3,PRKG1,HPSE2,TNIK,MGAT4C,FMN2,NTRK2
2.622e-05	-10.55	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	23	16828	48	PRKG1,NPAS3,TNIK,HPSE2,MGAT4C,NTRK2,CLU,RYR3,NRG3,SLC1A3,ERBB4,LRP1B,MSI2,MACF1,DTNA,TRPM3,GPC5,PITPNC1,FMN2,CTNND2,LSAMP,ADCY2,PARD3
3.096e-05	-10.38	sarcolemma	cellular component	GO:0042383	142	5	19108	49	AQP4,PRKG1,RYR3,DTNA,ATP1A2
3.219e-05	-10.34	trunk	COSMIC cancer mutations	trunk	3554	23	16828	48	ATP1A2,CDH20,LSAMP,CTNND2,PARD3,HPSE2,NPAS3,NEBL,SLC14A1,DCLK2,NTRK2,TRPS1,MGAT4C,DGKG,SLC1A3,ERBB4,RYR3,NRG3,SOX5,TNC,MACF1,LRP1B,GLIS3
3.271e-05	-10.33	synapse organization	biological process	GO:0050808	333	7	18204	50	NFIA,TNC,ERBB4,NRG3,GPM6A,CTNND2,APOE
3.994e-05	-10.13	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	10	16828	48	LRP1B,NTRK2,SOX5,TRPS1,PARD3,DTNA,CTNND2,NEBL,SLC1A3,PRKG1
4.215e-05	-10.07	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	5	19454	50	CLU,GJA1,MACF1,TNIK,PRKG1
4.389e-05	-10.03	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	6	19454	50	TNIK,GJA1,SORBS1,NHSL1,NTRK2,ERBB4
4.550e-05	-10.00	Htt (huntingtin)	protein interactions	15194	77	4	19454	50	NTM,GPM6A,CNTN1,LSAMP
4.604e-05	-9.99	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	5	16828	48	PRKG1,PARD3,LRP1B,NRG3,GPC5
5.463e-05	-9.81	cellular component assembly	biological process	GO:0022607	2472	18	18204	50	SLC1A2,GPM6A,TNIK,CNTN1,GJA1,FMN2,SORBS1,RYR3,NRG3,RFX4,CLU,NEBL,ERBB4,CDH20,APOE,AQP4,TRPM3,PARD3
5.560e-05	-9.80	nodular	COSMIC cancer mutations	nodular	1515	14	16828	48	CNTN1,LRP1B,GLIS3,MACF1,CDH20,CTNND2,ERBB4,DGKG,FMN2,NTRK2,DCLK2,ATP1A2,NPAS3,NEBL
5.605e-05	-9.79	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	32	SLC1A3,SLC1A2
5.605e-05	-9.79	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	32	SLC1A3,SLC1A2
5.838e-05	-9.75	signaling	biological process	GO:0023052	4968	27	18204	50	PARD3,ATP1A2,APOE,ADCY2,MAPK10,FMN2,SORBS1,NRG3,PRKG1,TNIK,CNTN1,RORA,DCLK2,PITPNC1,DTNA,CTNND2,TNC,DGKG,CLU,NFIA,ERBB4,SLC1A3,GJA1,RYR3,SLC1A2,MACF1,NTRK2
6.103e-05	-9.70	synapse	cellular component	GO:0045202	1473	13	19108	49	TNIK,APOE,NRG3,CNTN1,NTRK2,ERBB4,GPM6A,SLC1A2,DTNA,ATP1A2,CLU,SLC1A3,CTNND2
6.184e-05	-9.69	dicarboxylic acid transport	biological process	GO:0006835	78	4	18204	50	NTRK2,GJA1,SLC1A3,SLC1A2
6.775e-05	-9.60	negative regulation of amyloid-beta formation	biological process	GO:1902430	29	3	18204	50	CLU,NTRK2,APOE
6.848e-05	-9.59	cell communication	biological process	GO:0007154	5010	27	18204	50	NFIA,CLU,ERBB4,SLC1A3,RYR3,GJA1,SLC1A2,MACF1,NTRK2,TNC,DGKG,ADCY2,FMN2,SORBS1,MAPK10,PRKG1,NRG3,TNIK,CNTN1,RORA,DCLK2,DTNA,CTNND2,PITPNC1,PARD3,ATP1A2,APOE
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A2,SLC1A3
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A2,SLC1A3
7.355e-05	-9.52	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	50	SLC1A2,SLC1A3
7.355e-05	-9.52	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	50	SLC1A3,SLC1A2
7.355e-05	-9.52	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	2	18204	50	CLU,APOE
7.513e-05	-9.50	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	50	SLC1A3,ATP1A2,SLC1A2
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	NTM,GPM6A,LSAMP
8.302e-05	-9.40	negative regulation of amyloid precursor protein catabolic process	biological process	GO:1902992	31	3	18204	50	NTRK2,APOE,CLU
9.082e-05	-9.31	membrane	cellular component	GO:0016020	9220	37	19108	49	SLC1A3,ADCY2,ATP1A2,GJA1,CLU,HPSE2,NKAIN3,PRKG1,GPM6A,SLC14A1,CST3,ERBB4,LRP1B,TRPM3,MACF1,FMN2,GPC5,SORBS1,NRG3,AQP4,NTM,LSAMP,CTNND2,TNC,CDH20,DTNA,SLC1A2,PARD3,DGKG,MGAT4C,CTNNA2,NTRK2,CNTN1,MAPK10,RYR3,APOE,TNIK
9.188e-05	-9.30	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	6	19454	50	FMN2,NHSL1,SORBS1,PRKG1,NEBL,PARD3
9.850e-05	-9.23	neuron projection development	biological process	GO:0031175	693	9	18204	50	TNC,PARD3,PRKG1,CTNNA2,GPM6A,CNTN1,TNIK,APOE,CTNND2
1.038e-04	-9.17	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	25	16828	48	FMN2,ATP1A2,DTNA,TRPM3,ADCY2,NHSL1,CNTN1,PARD3,CTNND2,RFX4,MGAT4C,TRPS1,PRKG1,GLIS3,GPM6A,LRP1B,MACF1,TNC,SOX5,CLU,RYR3,NRG3,SLC1A3,ERBB4,DGKG
1.038e-04	-9.17	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	25	16828	48	PARD3,NHSL1,ADCY2,CNTN1,RFX4,CTNND2,ATP1A2,FMN2,TRPM3,DTNA,TNC,MACF1,SOX5,GLIS3,LRP1B,GPM6A,DGKG,ERBB4,SLC1A3,RYR3,NRG3,CLU,TRPS1,MGAT4C,PRKG1
1.099e-04	-9.12	negative regulation of amide metabolic process	biological process	GO:0034249	34	3	18204	50	CLU,NTRK2,APOE
1.101e-04	-9.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	50	SLC1A3,SLC1A2
1.101e-04	-9.11	D-amino acid transport	biological process	GO:0042940	6	2	18204	50	SLC1A3,SLC1A2
1.101e-04	-9.11	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	2	18204	50	ERBB4,NRG3
1.149e-04	-9.07	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	16	19108	49	ADCY2,SLC1A3,CTNND2,PARD3,GPM6A,ATP1A2,CLU,SLC1A2,DTNA,CNTN1,MACF1,CTNNA2,NTRK2,APOE,AQP4,FMN2
1.167e-04	-9.06	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	4	19454	50	SORBS1,GJA1,NTRK2,PARD3
1.173e-04	-9.05	adherens junction	cellular component	GO:0005912	188	5	19108	49	CTNNA2,CTNND2,SORBS1,CDH20,PARD3
1.176e-04	-9.05	proteoglycan binding	molecular function	GO:0043394	36	3	18094	48	TNC,HPSE2,APOE
1.452e-04	-8.84	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	35	16828	48	ERBB4,SLC1A3,DGKG,CLU,NRG3,RYR3,MACF1,RORA,TNC,SOX5,APOE,GLIS3,LRP1B,GPM6A,PRKG1,NEBL,TNIK,HPSE2,TRPS1,DCLK2,NTRK2,SLC1A2,CTNND2,LSAMP,RFX4,CDH20,PARD3,NKAIN3,ADCY2,NHSL1,CNTN1,GPC5,TRPM3,ATP1A2,FMN2
1.476e-04	-8.82	DZIP1 (DAZ interacting zinc finger protein 1)	protein interactions	22873	40	3	19454	50	GJA1,NTRK2,PARD3
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A3,SLC1A2
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A3,SLC1A2
1.490e-04	-8.81	FLOT1 (flotillin 1)	protein interactions	10211	453	7	19454	50	FMN2,MACF1,DTNA,SORBS1,PARD3,SLC14A1,SOX5
1.528e-04	-8.79	scalp	COSMIC cancer mutations	scalp	2110	16	16828	48	PRKG1,NEBL,GPC5,ATP1A2,TRPS1,FMN2,ERBB4,NFIA,LSAMP,SOX5,SORBS1,MACF1,RORA,TNC,CNTN1,NTM
1.546e-04	-8.77	SDF	pfam domains	PF00375	7	2	17795	49	SLC1A2,SLC1A3
1.588e-04	-8.75	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	8	16828	48	CTNND2,RYR3,ERBB4,PRKG1,ADCY2,LRP1B,TRPS1,NTRK2
1.627e-04	-8.72	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	5	19454	50	GJA1,DTNA,RYR3,ATP1A2,PARD3
1.627e-04	-8.72	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	8	16828	48	CTNND2,RYR3,PRKG1,ERBB4,ADCY2,LRP1B,TRPS1,NTRK2
1.662e-04	-8.70	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	50	SLC1A2,SLC1A3,RYR3
1.695e-04	-8.68	cell migration	biological process	GO:0016477	921	10	18204	50	NTRK2,CDH20,GPM6A,NRG3,PRKG1,CTNNA2,GPC5,GJA1,FMN2,ERBB4
1.794e-04	-8.63	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	43	SLC1A3,SLC1A2
1.886e-04	-8.58	cellular component biogenesis	biological process	GO:0044085	2716	18	18204	50	CDH20,AQP4,APOE,PARD3,TRPM3,SLC1A2,CNTN1,TNIK,GPM6A,NEBL,CLU,ERBB4,FMN2,RYR3,SORBS1,GJA1,RFX4,NRG3
1.949e-04	-8.54	regulation of neuron projection development	biological process	GO:0010975	443	7	18204	50	APOE,NTRK2,TNIK,MACF1,CNTN1,CTNNA2,DGKG
2.035e-04	-8.50	cell projection	cellular component	GO:0042995	2398	16	19108	49	NTRK2,CTNNA2,MACF1,CNTN1,FMN2,AQP4,APOE,CTNND2,SLC1A3,ADCY2,SLC1A2,DTNA,CLU,ATP1A2,GPM6A,PARD3
2.048e-04	-8.49	ERBB4 signaling pathway	biological process	GO:0038130	8	2	18204	50	ERBB4,NRG3
2.048e-04	-8.49	protein import	biological process	GO:0017038	8	2	18204	50	APOE,CLU
2.053e-04	-8.49	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	12	16828	48	CDH20,CTNND2,NPAS3,NEBL,DGKG,ERBB4,LRP1B,GLIS3,NTRK2,ATP1A2,DCLK2,MACF1
2.066e-04	-8.48	cellular component organization	biological process	GO:0016043	5636	28	18204	50	DCLK2,PITPNC1,CTNND2,CST3,TNIK,CNTN1,SORBS1,FMN2,NRG3,RFX4,PRKG1,CDH20,APOE,TRPM3,PARD3,HPSE2,SLC1A2,GPM6A,MACF1,GJA1,RYR3,CLU,NEBL,NFIA,ERBB4,AQP4,CTNNA2,TNC
2.071e-04	-8.48	cellular response to endogenous stimulus	biological process	GO:0071495	1135	11	18204	50	NTRK2,SLC1A2,GJA1,RYR3,SORBS1,ERBB4,SLC1A3,NFIA,SOX5,ATP1A2,TNC
2.075e-04	-8.48	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	24	16828	48	CNTN1,NHSL1,ADCY2,SORBS1,PARD3,NFIA,CDH20,RFX4,CTNND2,FMN2,TRPM3,ZBTB20,NTM,LRP1B,GPM6A,SOX5,MACF1,NRG3,RYR3,NTRK2,TRPS1,HPSE2,TNIK,PRKG1
2.215e-04	-8.42	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	15	16828	48	FMN2,MGAT4C,TNIK,HPSE2,ZBTB20,NEBL,NPAS3,SOX5,MACF1,RORA,GPM6A,CNTN1,LRP1B,ERBB4,RYR3
2.241e-04	-8.40	larynx	COSMIC cancer mutations	larynx	1948	15	16828	48	GPM6A,LRP1B,CNTN1,RORA,MACF1,SOX5,RYR3,ERBB4,MGAT4C,FMN2,NEBL,NPAS3,TNIK,HPSE2,ZBTB20
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	NTM,LSAMP
2.392e-04	-8.34	CNTN1 (contactin 1)	protein interactions	1272	47	3	19454	50	TNC,CNTN1,GPM6A
2.526e-04	-8.28	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	43	SLC1A2,SLC1A3
2.526e-04	-8.28	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	43	SLC1A2,SLC1A3
2.564e-04	-8.27	OCLN (occludin)	protein interactions	100506658	495	7	19454	50	PARD3,GJA1,NTRK2,FMN2,TNIK,MACF1,DTNA
2.586e-04	-8.26	cellular response to organic cyclic compound	biological process	GO:0071407	464	7	18204	50	ATP1A2,SLC1A2,RORA,SLC1A3,TNC,ADCY2,RYR3
2.614e-04	-8.25	transporter activity	molecular function	GO:0005215	1211	11	18094	48	SLC1A2,PITPNC1,ATP1A2,SLC14A1,AQP4,GPM6A,TRPM3,GJA1,SLC1A3,RYR3,APOE
2.888e-04	-8.15	EDTRNSPORT	prints domains	PR00173	7	2	5227	20	SLC1A2,SLC1A3
2.903e-04	-8.14	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	41	16828	48	MACF1,TNC,RORA,APOE,SOX5,GLIS3,LRP1B,GPM6A,NTM,SLC1A3,DGKG,ERBB4,RYR3,NRG3,TRPS1,DCLK2,NTRK2,SLC1A2,MGAT4C,PRKG1,NPAS3,NEBL,TNIK,HPSE2,PARD3,SORBS1,NKAIN3,ADCY2,CNTN1,LSAMP,CTNND2,RFX4,CDH20,NFIA,ATP1A2,FMN2,ZBTB20,DTNA,TRPM3,GPC5,PITPNC1
2.903e-04	-8.14	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	41	16828	48	NTRK2,DCLK2,TRPS1,MGAT4C,SLC1A2,HPSE2,TNIK,NPAS3,NEBL,PRKG1,SOX5,APOE,TNC,MACF1,RORA,NTM,LRP1B,GPM6A,GLIS3,DGKG,SLC1A3,ERBB4,RYR3,NRG3,ATP1A2,FMN2,ZBTB20,PITPNC1,GPC5,TRPM3,DTNA,NKAIN3,SORBS1,PARD3,CNTN1,ADCY2,NFIA,CDH20,RFX4,LSAMP,CTNND2
2.945e-04	-8.13	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	6	19454	50	NEBL,PARD3,GJA1,TNIK,MACF1,SORBS1
3.038e-04	-8.10	DST (dystonin)	protein interactions	667	230	5	19454	50	GJA1,NTRK2,PARD3,ATP1A2,TNIK
3.050e-04	-8.10	FAM171B (family with sequence similarity 171 member B)	protein interactions	165215	51	3	19454	50	PARD3,GJA1,NTRK2
3.091e-04	-8.08	regulation of amyloid-beta formation	biological process	GO:1902003	48	3	18204	50	NTRK2,APOE,CLU
3.121e-04	-8.07	cell-cell junction	cellular component	GO:0005911	513	7	19108	49	PARD3,CDH20,GJA1,ATP1A2,SORBS1,CTNND2,CTNNA2
3.231e-04	-8.04	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	3	19454	50	SORBS1,ERBB4,NTRK2
3.272e-04	-8.02	striated muscle contraction	biological process	GO:0006941	120	4	18204	50	ATP1A2,GJA1,RYR3,DTNA
3.281e-04	-8.02	cellular response to cocaine	biological process	GO:0071314	10	2	18204	50	SLC1A2,SLC1A3
3.281e-04	-8.02	action potential propagation	biological process	GO:0098870	10	2	18204	50	ATP1A2,NTRK2
3.281e-04	-8.02	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	50	ATP1A2,NTRK2
3.283e-04	-8.02	glial cell differentiation	biological process	GO:0010001	219	5	18204	50	CLU,PARD3,NFIA,CNTN1,NTRK2
3.342e-04	-8.00	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	16	16828	48	TRPM3,HPSE2,ZBTB20,FMN2,SLC1A2,NTRK2,ATP1A2,RFX4,CTNND2,NRG3,DGKG,NHSL1,CNTN1,LRP1B,TNC,SOX5
3.354e-04	-8.00	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	5	19454	50	GJA1,NTRK2,PARD3,DTNA,MACF1
3.424e-04	-7.98	neuron projection morphogenesis	biological process	GO:0048812	486	7	18204	50	CTNND2,CNTN1,TNIK,GPM6A,PRKG1,CTNNA2,PARD3
3.642e-04	-7.92	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	7	18204	50	GPM6A,CNTN1,TNIK,PARD3,PRKG1,CTNNA2,CTNND2
3.646e-04	-7.92	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	15	16828	48	LSAMP,NRG3,ERBB4,LRP1B,GPM6A,PARD3,MACF1,RORA,MSI2,GPC5,TRPM3,AQP4,NEBL,FMN2,TRPS1
3.870e-04	-7.86	cell projection morphogenesis	biological process	GO:0048858	496	7	18204	50	PARD3,CTNNA2,PRKG1,CNTN1,TNIK,GPM6A,CTNND2
3.988e-04	-7.83	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	4	19454	50	ERBB4,NTRK2,DTNA,PARD3
4.003e-04	-7.82	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	50	SLC1A2,SLC1A3
4.003e-04	-7.82	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	50	SLC1A3,SLC1A2
4.003e-04	-7.82	glutamate secretion	biological process	GO:0014047	11	2	18204	50	NTRK2,GJA1
4.124e-04	-7.79	regulation of body fluid levels	biological process	GO:0050878	356	6	18204	50	GJA1,AQP4,DGKG,APOE,PRKG1,ERBB4
4.135e-04	-7.79	cellular component organization or biogenesis	biological process	GO:0071840	5850	28	18204	50	CDH20,APOE,HPSE2,PARD3,TRPM3,CST3,TNIK,CNTN1,DCLK2,CTNND2,PITPNC1,FMN2,SORBS1,RFX4,NRG3,PRKG1,AQP4,TNC,CTNNA2,SLC1A2,MACF1,GPM6A,NEBL,NFIA,CLU,ERBB4,RYR3,GJA1
4.155e-04	-7.79	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	2	10285	32	NRG3,ERBB4
4.182e-04	-7.78	myelination	biological process	GO:0042552	128	4	18204	50	NTRK2,CNTN1,CLU,PARD3
4.182e-04	-7.78	glial cell development	biological process	GO:0021782	128	4	18204	50	NTRK2,CLU,PARD3,CNTN1
4.203e-04	-7.77	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	2	19454	50	CLU,APOE
4.243e-04	-7.77	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	8	18204	50	CTNNA2,DGKG,APOE,NTRK2,GPM6A,CNTN1,TNIK,MACF1
4.294e-04	-7.75	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	5	5310	22	NTRK2,SLC1A3,RORA,GJA1,AQP4
4.301e-04	-7.75	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	50	PARD3,MSI2,ERBB4,DTNA,MACF1,FMN2,TNIK,SLC1A3
4.404e-04	-7.73	Ig_I-set	interpro domains	IPR013098	132	4	18521	50	NTM,CNTN1,NTRK2,LSAMP
4.434e-04	-7.72	ensheathment of neurons	biological process	GO:0007272	130	4	18204	50	NTRK2,CLU,PARD3,CNTN1
4.434e-04	-7.72	axon ensheathment	biological process	GO:0008366	130	4	18204	50	CLU,PARD3,CNTN1,NTRK2
4.626e-04	-7.68	regulation of amyloid precursor protein catabolic process	biological process	GO:1902991	55	3	18204	50	CLU,APOE,NTRK2
4.698e-04	-7.66	amino acid transport	biological process	GO:0006865	132	4	18204	50	NTRK2,GJA1,SLC1A3,SLC1A2
4.733e-04	-7.66	I-set	pfam domains	PF07679	132	4	17795	49	CNTN1,NTM,LSAMP,NTRK2
4.785e-04	-7.64	cytoskeleton organization	biological process	GO:0007010	1251	11	18204	50	MACF1,TNIK,APOE,DCLK2,NEBL,PARD3,PRKG1,CTNNA2,GJA1,SORBS1,FMN2
4.842e-04	-7.63	signal transduction	biological process	GO:0007165	4637	24	18204	50	DGKG,MACF1,NTRK2,ERBB4,CLU,NFIA,GJA1,RYR3,ATP1A2,APOE,PARD3,TNIK,CNTN1,PITPNC1,DTNA,CTNND2,DCLK2,RORA,ADCY2,PRKG1,NRG3,MAPK10,SORBS1,FMN2
5.016e-04	-7.60	regulation of cell projection organization	biological process	GO:0031344	683	8	18204	50	DGKG,CTNNA2,CNTN1,MACF1,TNIK,GPM6A,NTRK2,APOE
5.158e-04	-7.57	tibia	COSMIC cancer mutations	tibia	836	9	16828	48	PRKG1,TNIK,TRPM3,LSAMP,CTNND2,MACF1,NKAIN3,GPM6A,LRP1B
5.266e-04	-7.55	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	8	18094	48	AQP4,GPM6A,RYR3,SLC14A1,SLC1A3,ATP1A2,SLC1A2,TRPM3
5.644e-04	-7.48	LRP2 (LDL receptor related protein 2)	protein interactions	4036	148	4	19454	50	LRP1B,CLU,APOE,GJA1
5.657e-04	-7.48	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	2	18204	50	APOE,CLU
5.676e-04	-7.47	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	12	16828	48	TNIK,TRPM3,GPC5,TRPS1,FMN2,LSAMP,CTNND2,RYR3,PARD3,SORBS1,LRP1B,CNTN1
5.776e-04	-7.46	C9 (complement C9)	protein interactions	735	14	2	19454	50	APOE,CLU
5.776e-04	-7.46	PLXNA4 (plexin A4)	protein interactions	91584	14	2	19454	50	GPM6A,CLU
6.069e-04	-7.41	cellular response to stimulus	biological process	GO:0051716	6307	29	18204	50	AQP4,DGKG,ZBTB20,TNC,NTRK2,MACF1,SLC1A2,RYR3,GJA1,ERBB4,SLC1A3,NFIA,CLU,APOE,ATP1A2,PARD3,DTNA,CTNND2,PITPNC1,RORA,DCLK2,CNTN1,TNIK,PRKG1,NRG3,SORBS1,FMN2,MAPK10,ADCY2
6.084e-04	-7.40	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	17	16828	48	TNC,SOX5,ADCY2,NHSL1,CNTN1,LRP1B,DGKG,CTNND2,RFX4,NRG3,ATP1A2,NTRK2,SLC1A2,FMN2,ZBTB20,HPSE2,TRPM3
6.128e-04	-7.40	pancreas-carcinoma-adenocarcinoma	COSMIC cancer mutations	pancreas-carcinoma-adenocarcinoma	517	7	16828	48	LRP1B,TNC,MACF1,DCLK2,GPC5,NEBL,HPSE2
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A3,SLC1A2
6.187e-04	-7.39	glutamatergic synapse	cellular component	GO:0098978	412	6	19108	49	NRG3,APOE,GPM6A,TNIK,ERBB4,SLC1A2
6.187e-04	-7.39	neuron migration	biological process	GO:0001764	142	4	18204	50	GPM6A,NTRK2,PRKG1,GJA1
6.214e-04	-7.38	face	COSMIC cancer mutations	face	2139	15	16828	48	GPM6A,LRP1B,MSI2,PARD3,RORA,MACF1,NRG3,LSAMP,ERBB4,FMN2,TRPS1,GPC5,TRPM3,AQP4,NEBL
6.523e-04	-7.34	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	3	19454	50	CLU,APOE,GJA1
6.623e-04	-7.32	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	17	16828	48	ATP1A2,TRPS1,MGAT4C,HPSE2,NEBL,SLC14A1,SOX5,TNC,PARD3,LRP1B,ERBB4,SLC1A3,CDH20,RYR3,NRG3,CTNND2,LSAMP
6.635e-04	-7.32	FLOT2 (flotillin 2)	protein interactions	2319	273	5	19454	50	PARD3,SLC14A1,GJA1,SOX5,NTRK2
6.654e-04	-7.32	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	2	19454	50	PARD3,TNIK
7.028e-04	-7.26	cell motility	biological process	GO:0048870	1101	10	18204	50	CDH20,NTRK2,GPM6A,FMN2,GPC5,GJA1,PRKG1,CTNNA2,NRG3,ERBB4
7.118e-04	-7.25	PLCH1 (phospholipase C eta 1)	protein interactions	23007	68	3	19454	50	PARD3,GJA1,NTRK2
7.161e-04	-7.24	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	2	10285	32	NRG3,ERBB4
8.042e-04	-7.13	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	46	16828	48	NTRK2,DCLK2,TRPS1,TNIK,NPAS3,PRKG1,LRP1B,GLIS3,TNC,MACF1,RYR3,NRG3,ERBB4,PITPNC1,TRPM3,GPC5,DTNA,ZBTB20,NHSL1,ADCY2,NKAIN3,SORBS1,PARD3,CDH20,LSAMP,MGAT4C,SLC1A2,CST3,SLC14A1,HPSE2,NEBL,NTM,GPM6A,SOX5,APOE,RORA,MSI2,CLU,SLC1A3,DGKG,FMN2,ATP1A2,CNTN1,NFIA,RFX4,CTNND2
8.059e-04	-7.12	response to stimulus	biological process	GO:0050896	7803	33	18204	50	NRG3,PRKG1,MAPK10,FMN2,SORBS1,ADCY2,PITPNC1,DTNA,CTNND2,RORA,DCLK2,TNIK,CNTN1,CST3,PARD3,APOE,SOX5,ATP1A2,GJA1,RYR3,ERBB4,SLC1A3,CLU,NFIA,NTRK2,GPM6A,MACF1,SLC1A2,ZBTB20,CTNNA2,DGKG,TNC,AQP4
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	ZBTB20,LSAMP
8.309e-04	-7.09	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	5	19454	50	SORBS1,GJA1,NTRK2,PARD3,DTNA
8.338e-04	-7.09	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	2	10285	32	NRG3,ERBB4
8.382e-04	-7.08	hindbrain development	biological process	GO:0030902	154	4	18204	50	CNTN1,CTNNA2,PRKG1,RORA
8.536e-04	-7.07	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	39	16828	48	GJA1,PITPNC1,GPC5,TRPM3,DTNA,ATP1A2,FMN2,NFIA,CDH20,RFX4,CTNND2,NKAIN3,SORBS1,PARD3,CNTN1,HPSE2,TNIK,NPAS3,NEBL,PRKG1,CST3,SLC14A1,NTRK2,DCLK2,TRPS1,MGAT4C,ERBB4,DGKG,RYR3,NRG3,CLU,SOX5,TNC,RORA,MACF1,MSI2,NTM,GPM6A,LRP1B
8.591e-04	-7.06	membrane raft	cellular component	GO:0045121	290	5	19108	49	SLC1A2,SORBS1,ATP1A2,GJA1,ADCY2
8.637e-04	-7.05	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	8	10285	32	SLC14A1,ADCY2,TRPM3,SLC1A2,SLC1A3,RYR3,ATP1A2,AQP4
8.653e-04	-7.05	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	39	16828	48	SOX5,MSI2,MACF1,RORA,TNC,GPM6A,LRP1B,NTM,DGKG,ERBB4,CLU,RYR3,NRG3,DCLK2,NTRK2,TRPS1,MGAT4C,TNIK,HPSE2,PRKG1,NEBL,NPAS3,CST3,SLC14A1,SORBS1,NKAIN3,PARD3,CNTN1,CDH20,NFIA,CTNND2,RFX4,ATP1A2,FMN2,GJA1,PITPNC1,DTNA,GPC5,TRPM3
8.657e-04	-7.05	asymmetric cell division	biological process	GO:0008356	16	2	18204	50	PARD3,SOX5
8.657e-04	-7.05	locomotory exploration behavior	biological process	GO:0035641	16	2	18204	50	APOE,ATP1A2
8.860e-04	-7.03	membrane microdomain	cellular component	GO:0098857	292	5	19108	49	GJA1,ATP1A2,SORBS1,SLC1A2,ADCY2
8.927e-04	-7.02	vascular process in circulatory system	biological process	GO:0003018	273	5	18204	50	SLC1A3,ATP1A2,SLC1A2,PRKG1,APOE
8.975e-04	-7.02	presynaptic membrane	cellular component	GO:0042734	168	4	19108	49	CNTN1,GPM6A,SLC1A2,ERBB4
9.223e-04	-6.99	gliogenesis	biological process	GO:0042063	275	5	18204	50	CNTN1,NFIA,PARD3,CLU,NTRK2
9.341e-04	-6.98	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	5	16828	48	RYR3,LRP1B,CDH20,SOX5,APOE
9.346e-04	-6.98	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	20	16828	48	FMN2,ATP1A2,TRPM3,GPC5,NEBL,TNIK,HPSE2,ZBTB20,ADCY2,NHSL1,LRP1B,GPM6A,MACF1,PARD3,TNC,SOX5,CTNND2,RYR3,NRG3,DGKG
9.417e-04	-6.97	middle_third	COSMIC cancer mutations	middle_third	3533	20	16828	48	GPC5,TRPM3,NEBL,HPSE2,ZBTB20,TNIK,FMN2,ATP1A2,CTNND2,RYR3,NRG3,DGKG,NHSL1,ADCY2,GPM6A,LRP1B,TNC,MACF1,PARD3,SOX5
9.444e-04	-6.96	cell adhesion	biological process	GO:0007155	942	9	18204	50	CTNNA2,LSAMP,SORBS1,TNC,PARD3,CTNND2,CDH20,CNTN1,NTM
9.602e-04	-6.95	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	2	10285	32	ERBB4,NRG3
9.621e-04	-6.95	dendrite	cellular component	GO:0030425	620	7	19108	49	APOE,ADCY2,GPM6A,CLU,ATP1A2,CTNND2,NTRK2
9.788e-04	-6.93	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	10	16828	48	ADCY2,LRP1B,MGAT4C,NTM,TNC,MACF1,SORBS1,CTNND2,ERBB4,PRKG1
9.794e-04	-6.93	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	2	18204	50	GJA1,ATP1A2
9.794e-04	-6.93	regulation of amyloid fibril formation	biological process	GO:1905906	17	2	18204	50	APOE,CLU
9.794e-04	-6.93	reverse cholesterol transport	biological process	GO:0043691	17	2	18204	50	APOE,CLU
9.803e-04	-6.93	dendritic tree	cellular component	GO:0097447	622	7	19108	49	CTNND2,NTRK2,ADCY2,ATP1A2,CLU,APOE,GPM6A
9.965e-04	-6.91	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	10	18204	50	PRKG1,RFX4,CTNNA2,TNC,PARD3,APOE,CTNND2,GPM6A,TNIK,CNTN1
1.022e-03	-6.89	ADGRL2 (adhesion G protein-coupled receptor L2)	protein interactions	23266	77	3	19454	50	PARD3,GJA1,NTRK2
1.024e-03	-6.88	cytoskeletal protein binding	molecular function	GO:0008092	989	9	18094	48	APOE,DCLK2,NEBL,CLU,CTNNA2,FMN2,SORBS1,GJA1,MACF1
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A3,SLC1A2
1.026e-03	-6.88	heparan sulfate proteoglycan binding	molecular function	GO:0043395	18	2	18094	48	APOE,HPSE2
1.049e-03	-6.86	animal organ development	biological process	GO:0048513	2846	17	18204	50	ERBB4,NFIA,NEBL,PRKG1,NRG3,RFX4,GJA1,GPM6A,CNTN1,SLC1A2,NTRK2,RORA,DCLK2,TNC,CTNNA2,ATP1A2,SOX5
1.053e-03	-6.86	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	6	19454	50	CTNND2,PARD3,FMN2,MACF1,DTNA,ERBB4
1.057e-03	-6.85	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	6	18094	48	GPM6A,ATP1A2,RYR3,SLC1A2,TRPM3,SLC1A3
1.071e-03	-6.84	astrocyte projection	cellular component	GO:0097449	19	2	19108	49	SLC1A2,AQP4
1.080e-03	-6.83	prostate	COSMIC cancer mutations	prostate	13883	47	16828	48	ZBTB20,GPC5,TRPM3,DTNA,PITPNC1,PARD3,NKAIN3,SORBS1,NHSL1,ADCY2,LSAMP,CDH20,TRPS1,NTRK2,DCLK2,NPAS3,PRKG1,TNIK,MACF1,TNC,GLIS3,LRP1B,ERBB4,NRG3,RYR3,ATP1A2,FMN2,GJA1,CNTN1,RFX4,CTNND2,NFIA,MGAT4C,SLC1A2,NEBL,AQP4,HPSE2,SLC14A1,RORA,MSI2,APOE,SOX5,NTM,GPM6A,SLC1A3,DGKG,CLU
1.095e-03	-6.82	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	2	10285	32	ERBB4,NRG3
1.095e-03	-6.82	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	2	10285	32	NRG3,ERBB4
1.100e-03	-6.81	negative regulation of platelet activation	biological process	GO:0010544	18	2	18204	50	PRKG1,APOE
1.100e-03	-6.81	positive regulation of circadian rhythm	biological process	GO:0042753	18	2	18204	50	RORA,PRKG1
1.104e-03	-6.81	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	44	16828	48	AQP4,NPAS3,NEBL,PRKG1,HPSE2,TNIK,TRPS1,NTRK2,DCLK2,MGAT4C,SLC1A2,ERBB4,DGKG,SLC1A3,RYR3,NRG3,CLU,MACF1,TNC,RORA,MSI2,SOX5,GLIS3,NTM,LRP1B,GPM6A,ZBTB20,TRPM3,GPC5,DTNA,PITPNC1,ATP1A2,FMN2,RFX4,CTNND2,LSAMP,NFIA,CDH20,PARD3,NKAIN3,SORBS1,NHSL1,ADCY2,CNTN1
1.114e-03	-6.80	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	8	16828	48	CDH20,NRG3,ERBB4,GJA1,LRP1B,MACF1,PARD3,TNC
1.117e-03	-6.80	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	22	16828	48	GJA1,TRPM3,FMN2,CDH20,NFIA,CTNND2,SORBS1,PARD3,ADCY2,NHSL1,AQP4,NPAS3,TRPS1,SLC1A3,CLU,RYR3,APOE,MACF1,TNC,RORA,LRP1B,GLIS3
1.120e-03	-6.79	response to wounding	biological process	GO:0009611	431	6	18204	50	SLC1A2,MACF1,NFIA,SLC1A3,TNC,DGKG
1.124e-03	-6.79	ERBB4 (erb-b2 receptor tyrosine kinase 4)	protein interactions	2066	178	4	19454	50	ERBB4,NTRK2,GJA1,NRG3
1.145e-03	-6.77	water transmembrane transporter activity	molecular function	GO:0005372	19	2	18094	48	AQP4,SLC14A1
1.172e-03	-6.75	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	5	19454	50	DTNA,MACF1,TNIK,FMN2,PARD3
1.194e-03	-6.73	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	2	19454	50	CTNND2,CST3
1.221e-03	-6.71	postsynapse	cellular component	GO:0098794	646	7	19108	49	CNTN1,NTRK2,ERBB4,CTNND2,TNIK,GPM6A,ATP1A2
1.226e-03	-6.70	GSC (goosecoid homeobox)	protein interactions	145258	82	3	19454	50	SOX5,NFIA,TRPS1
1.227e-03	-6.70	regulation of amyloid-beta clearance	biological process	GO:1900221	19	2	18204	50	APOE,CLU
1.227e-03	-6.70	negative regulation of alcohol biosynthetic process	biological process	GO:1902931	19	2	18204	50	PRKG1,APOE
1.235e-03	-6.70	response to endogenous stimulus	biological process	GO:0009719	1402	11	18204	50	TNC,ERBB4,SLC1A3,NFIA,SORBS1,RYR3,GJA1,ATP1A2,SLC1A2,NTRK2,SOX5
1.246e-03	-6.69	somatodendritic compartment	cellular component	GO:0036477	842	8	19108	49	SLC1A3,NTRK2,CTNND2,ADCY2,ATP1A2,CLU,GPM6A,APOE
1.246e-03	-6.69	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	28	16828	48	ERBB4,SLC1A3,DGKG,NRG3,CLU,TNC,MACF1,GPM6A,LRP1B,GLIS3,HPSE2,NEBL,PRKG1,NTRK2,TRPS1,MGAT4C,NFIA,CDH20,RFX4,SORBS1,PARD3,ADCY2,ZBTB20,GPC5,TRPM3,DTNA,ATP1A2,FMN2
1.254e-03	-6.68	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	28	16828	48	ATP1A2,FMN2,ZBTB20,GPC5,TRPM3,DTNA,PARD3,SORBS1,ADCY2,RFX4,NFIA,CDH20,TRPS1,NTRK2,MGAT4C,NEBL,PRKG1,HPSE2,MACF1,TNC,GLIS3,GPM6A,LRP1B,SLC1A3,ERBB4,DGKG,NRG3,CLU
1.266e-03	-6.67	axon	cellular component	GO:0030424	650	7	19108	49	CNTN1,NTRK2,CTNNA2,GPM6A,PARD3,SLC1A2,DTNA
1.289e-03	-6.65	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	6	18204	50	PARD3,SLC1A3,CNTN1,CTNNA2,PRKG1,CTNND2
1.293e-03	-6.65	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	9	16828	48	FMN2,CNTN1,LRP1B,SLC1A2,MACF1,TNC,PARD3,GPC5,TRPM3
1.293e-03	-6.65	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	9	16828	48	TRPM3,GPC5,SLC1A2,CNTN1,LRP1B,FMN2,TNC,PARD3,MACF1
1.299e-03	-6.65	muscle system process	biological process	GO:0003012	297	5	18204	50	ATP1A2,GJA1,RYR3,PRKG1,DTNA
1.299e-03	-6.65	carboxylic acid transport	biological process	GO:0046942	297	5	18204	50	SLC1A2,SLC1A3,GJA1,NTRK2,APOE
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	SORBS1,MACF1
1.318e-03	-6.63	SHC4 (SHC adaptor protein 4)	protein interactions	399694	21	2	19454	50	NTRK2,ERBB4
1.318e-03	-6.63	organic acid transport	biological process	GO:0015849	298	5	18204	50	NTRK2,APOE,GJA1,SLC1A3,SLC1A2
1.359e-03	-6.60	cell projection organization	biological process	GO:0030030	1200	10	18204	50	GPM6A,CNTN1,TNIK,APOE,CTNND2,TNC,PARD3,RFX4,PRKG1,CTNNA2
1.361e-03	-6.60	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	50	SLC1A3,SLC1A2
1.384e-03	-6.58	gallbladder	COSMIC cancer mutations	gallbladder	2821	17	16828	48	NRG3,RYR3,CLU,CTNND2,ERBB4,LRP1B,NHSL1,NKAIN3,PARD3,MACF1,TNC,PITPNC1,TRPM3,TNIK,PRKG1,FMN2,TRPS1
1.384e-03	-6.58	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	17	16828	48	NHSL1,LRP1B,MACF1,TNC,PARD3,NKAIN3,CTNND2,CLU,RYR3,NRG3,ERBB4,FMN2,TRPS1,TRPM3,PITPNC1,PRKG1,TNIK
1.397e-03	-6.57	bone	COSMIC cancer mutations	bone	8157	34	16828	48	ATP1A2,FMN2,ZBTB20,DTNA,GPC5,TRPM3,SORBS1,NKAIN3,PARD3,CNTN1,ADCY2,LSAMP,CTNND2,DCLK2,NTRK2,TRPS1,TNIK,HPSE2,PRKG1,NEBL,NPAS3,CST3,SOX5,TNC,MACF1,RORA,LRP1B,GPM6A,GLIS3,ERBB4,DGKG,SLC1A3,RYR3,NRG3
1.407e-03	-6.57	FAM171A1 (family with sequence similarity 171 member A1)	protein interactions	221061	86	3	19454	50	PARD3,GJA1,NTRK2
1.431e-03	-6.55	regulation of amide metabolic process	biological process	GO:0034248	81	3	18204	50	NTRK2,APOE,CLU
1.453e-03	-6.53	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	22	16828	48	CTNND2,NFIA,CDH20,NHSL1,ADCY2,PARD3,SORBS1,TRPM3,GJA1,FMN2,RYR3,CLU,SLC1A3,GLIS3,LRP1B,MACF1,RORA,TNC,APOE,NPAS3,AQP4,TRPS1
1.470e-03	-6.52	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	8	16828	48	CTNND2,ERBB4,PRKG1,TNIK,ADCY2,NTRK2,DCLK2,SOX5
1.470e-03	-6.52	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	8	16828	48	NTRK2,DCLK2,SOX5,ADCY2,ERBB4,PRKG1,TNIK,CTNND2
1.484e-03	-6.51	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	5	19454	50	TNIK,DTNA,PARD3,GJA1,SORBS1
1.546e-03	-6.47	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-virilizing_syndrome_producing	298	5	16828	48	ATP1A2,TNC,FMN2,LRP1B,CTNND2
1.582e-03	-6.45	ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8)	protein interactions	29801	23	2	19454	50	GJA1,PARD3
1.582e-03	-6.45	TIMM10B (translocase of inner mitochondrial membrane 10B)	protein interactions	26515	23	2	19454	50	HPSE2,MSI2
1.587e-03	-6.45	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	4	18204	50	ZBTB20,PRKG1,SORBS1,RORA
1.589e-03	-6.44	regulation of sodium ion transport	biological process	GO:0002028	84	3	18204	50	ATP1A2,CNTN1,NKAIN3
1.593e-03	-6.44	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	5	16828	48	TRPS1,MACF1,PRKG1,RYR3,GPC5
1.644e-03	-6.41	oligodendrocyte differentiation	biological process	GO:0048709	85	3	18204	50	CLU,CNTN1,NTRK2
1.649e-03	-6.41	negative regulation of muscle contraction	biological process	GO:0045932	22	2	18204	50	ATP1A2,PRKG1
1.649e-03	-6.41	cell communication by electrical coupling	biological process	GO:0010644	22	2	18204	50	GJA1,ATP1A2
1.649e-03	-6.41	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	50	ATP1A2,SLC1A3
1.655e-03	-6.40	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	3	19454	50	CNTN1,GPM6A,NTM
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A2,SLC1A3
1.696e-03	-6.38	amyloid-beta binding	molecular function	GO:0001540	89	3	18094	48	APOE,CST3,CLU
1.700e-03	-6.38	vascular transport	biological process	GO:0010232	86	3	18204	50	SLC1A2,ATP1A2,SLC1A3
1.700e-03	-6.38	transport across blood-brain barrier	biological process	GO:0150104	86	3	18204	50	ATP1A2,SLC1A3,SLC1A2
1.707e-03	-6.37	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	12	16828	48	MACF1,PARD3,SOX5,LRP1B,ERBB4,DCLK2,PRKG1,NEBL,NPAS3,ZBTB20,TRPM3,GPC5
1.731e-03	-6.36	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	29	16828	48	TNC,MACF1,SOX5,GLIS3,LRP1B,GPM6A,ERBB4,NRG3,RYR3,TRPS1,DCLK2,MGAT4C,PRKG1,NPAS3,NEBL,AQP4,TNIK,HPSE2,PARD3,SORBS1,ADCY2,CNTN1,CTNND2,ATP1A2,FMN2,ZBTB20,GPC5,TRPM3,PITPNC1
1.775e-03	-6.33	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	13	16828	48	FMN2,NTRK2,PITPNC1,NEBL,HPSE2,ADCY2,LRP1B,PARD3,TNC,RYR3,CDH20,DGKG,ERBB4
1.776e-03	-6.33	Prot_kinase_dom	interpro domains	IPR000719	480	6	18521	50	DCLK2,ERBB4,TNIK,NTRK2,MAPK10,PRKG1
1.784e-03	-6.33	extremity	COSMIC cancer mutations	extremity	1876	13	16828	48	TNC,PARD3,ADCY2,LRP1B,ERBB4,DGKG,CDH20,RYR3,NTRK2,FMN2,NEBL,HPSE2,PITPNC1
1.785e-03	-6.33	regulation of lipid biosynthetic process	biological process	GO:0046890	189	4	18204	50	SORBS1,PRKG1,ZBTB20,APOE
1.803e-03	-6.32	relaxation of muscle	biological process	GO:0090075	23	2	18204	50	ATP1A2,PRKG1
1.813e-03	-6.31	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	4	16828	48	NRG3,RYR3,LRP1B,GPC5
1.829e-03	-6.30	ear	COSMIC cancer mutations	ear	624	7	16828	48	MGAT4C,LRP1B,SLC14A1,ZBTB20,NPAS3,TNC,PRKG1
1.832e-03	-6.30	low-density lipoprotein particle receptor binding	molecular function	GO:0050750	24	2	18094	48	APOE,CLU
1.870e-03	-6.28	TNC (tenascin C)	protein interactions	3371	25	2	19454	50	CNTN1,CLU
1.875e-03	-6.28	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	3	18204	50	SORBS1,ZBTB20,APOE
1.898e-03	-6.27	HS-GAG degradation	REACTOME pathways	R-HSA-2024096	21	2	10285	32	HPSE2,GPC5
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr3q27.2-q27.3	chromosome location	human chr3q27.2-q27.3	1	1	26134	50	DGKG
1.913e-03	-6.26	human chr10p11.22-p11.21	chromosome location	human chr10p11.22-p11.21	1	1	26134	50	PARD3
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr12q21.31-q21.32	chromosome location	human chr12q21.31-q21.32	1	1	26134	50	MGAT4C
1.913e-03	-6.26	human chr10q11.23-q21.1	chromosome location	human chr10q11.23-q21.1	1	1	26134	50	PRKG1
1.913e-03	-6.26	human chr2q22.1-q22.2	chromosome location	human chr2q22.1-q22.2	1	1	26134	50	LRP1B
1.913e-03	-6.26	human chr4q31.23-q31.3	chromosome location	human chr4q31.23-q31.3	1	1	26134	50	DCLK2
1.928e-03	-6.25	anchoring junction	cellular component	GO:0070161	902	8	19108	49	CTNNA2,CTNND2,TNC,SORBS1,ATP1A2,GJA1,CDH20,PARD3
1.973e-03	-6.23	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	9	18204	50	SLC1A3,TNC,ADCY2,ZBTB20,GJA1,RYR3,SORBS1,SLC1A2,RORA
1.982e-03	-6.22	regulation of lipid metabolic process	biological process	GO:0019216	327	5	18204	50	PRKG1,ZBTB20,APOE,RORA,SORBS1
2.002e-03	-6.21	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	7	16828	48	SORBS1,TNC,NTM,FMN2,ERBB4,NEBL,NFIA
2.013e-03	-6.21	high-density lipoprotein particle	cellular component	GO:0034364	26	2	19108	49	APOE,CLU
2.022e-03	-6.20	channel activity	molecular function	GO:0015267	502	6	18094	48	TRPM3,GJA1,SLC14A1,AQP4,GPM6A,RYR3
2.042e-03	-6.19	passive transmembrane transporter activity	molecular function	GO:0022803	503	6	18094	48	SLC14A1,TRPM3,GJA1,AQP4,GPM6A,RYR3
2.047e-03	-6.19	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	3	19454	50	CNTN1,GPM6A,LSAMP
2.062e-03	-6.18	protein tetramerization	biological process	GO:0051262	92	3	18204	50	RYR3,AQP4,TRPM3
2.062e-03	-6.18	Bile secretion	KEGG pathways	hsa04976	71	3	7161	26	ATP1A2,AQP4,ADCY2
2.062e-03	-6.18	Bile secretion	KEGG pathways	ko04976	71	3	7161	26	ATP1A2,AQP4,ADCY2
2.077e-03	-6.18	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	7	18094	48	DGKG,TNIK,PRKG1,ERBB4,DCLK2,NTRK2,MAPK10
2.084e-03	-6.17	SHC1 events in ERBB2 signaling	REACTOME pathways	R-HSA-1250196	22	2	10285	32	ERBB4,NRG3
2.090e-03	-6.17	regulation of small molecule metabolic process	biological process	GO:0062012	331	5	18204	50	APOE,PRKG1,ZBTB20,SORBS1,RORA
2.130e-03	-6.15	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	50	SLC1A3,SLC1A2
2.141e-03	-6.15	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	5	16828	48	LRP1B,FMN2,CTNND2,ATP1A2,TNC
2.147e-03	-6.14	Adherens junction	KEGG pathways	ko04520	72	3	7161	26	PARD3,CTNNA2,SORBS1
2.147e-03	-6.14	Adherens junction	KEGG pathways	hsa04520	72	3	7161	26	SORBS1,CTNNA2,PARD3
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	DTNA,CTNNA2,CDH20
2.158e-03	-6.14	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	31	16828	48	GPC5,FMN2,ATP1A2,RFX4,CTNND2,LSAMP,CDH20,NHSL1,ADCY2,CNTN1,PARD3,NKAIN3,NEBL,PRKG1,HPSE2,SLC1A2,NTRK2,RYR3,NRG3,CLU,ERBB4,DGKG,SLC1A3,GLIS3,LRP1B,GPM6A,RORA,TNC,MACF1,SOX5,APOE
2.181e-03	-6.13	HPCAL4 (hippocalcin like 4)	protein interactions	51440	27	2	19454	50	AQP4,GPM6A
2.181e-03	-6.13	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	15	16828	48	NPAS3,TRPM3,TRPS1,FMN2,SLC1A3,CLU,CDH20,RYR3,NFIA,SORBS1,APOE,MACF1,PARD3,LRP1B,NHSL1
2.181e-03	-6.13	alveolar	COSMIC cancer mutations	alveolar	2414	15	16828	48	APOE,SORBS1,PARD3,MACF1,LRP1B,NHSL1,SLC1A3,CLU,CDH20,NFIA,RYR3,TRPS1,FMN2,NPAS3,TRPM3
2.183e-03	-6.13	intracellular signal transduction	biological process	GO:0035556	1505	11	18204	50	DCLK2,TNIK,FMN2,RYR3,MAPK10,PRKG1,NRG3,ADCY2,APOE,ATP1A2,DGKG
2.200e-03	-6.12	EZR (ezrin)	protein interactions	7430	526	6	19454	50	DTNA,TNIK,MACF1,NEBL,SORBS1,MAPK10
2.207e-03	-6.12	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	4	19454	50	NTRK2,ERBB4,NHSL1,TNIK
2.225e-03	-6.11	parathyroid	COSMIC cancer mutations	parathyroid	476	6	16828	48	GPM6A,MACF1,TRPS1,RYR3,GPC5,PRKG1
2.282e-03	-6.08	transmembrane transporter activity	molecular function	GO:0022857	1110	9	18094	48	RYR3,GPM6A,AQP4,SLC1A3,SLC14A1,ATP1A2,GJA1,TRPM3,SLC1A2
2.291e-03	-6.08	CAV1 (caveolin 1)	protein interactions	857	719	7	19454	50	SLC1A3,MACF1,DTNA,TNIK,FMN2,PARD3,GJA1
2.304e-03	-6.07	central nervous system myelination	biological process	GO:0022010	26	2	18204	50	CNTN1,CLU
2.304e-03	-6.07	axon ensheathment in central nervous system	biological process	GO:0032291	26	2	18204	50	CNTN1,CLU
2.304e-03	-6.07	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	50	SLC1A2,SLC1A3
2.319e-03	-6.07	CTNNB1 (catenin beta 1)	protein interactions	1499	926	8	19454	50	SORBS1,NHSL1,APOE,DTNA,CTNNA2,GJA1,PARD3,CTNND2
2.345e-03	-6.06	LRRC7 (leucine rich repeat containing 7)	protein interactions	57554	28	2	19454	50	CTNND2,ERBB4
2.358e-03	-6.05	ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)	protein interactions	25921	103	3	19454	50	PARD3,NTRK2,GJA1
2.368e-03	-6.05	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	40	16828	48	ERBB4,SLC1A3,DGKG,CLU,RYR3,NRG3,SOX5,MSI2,TNC,RORA,MACF1,LRP1B,NTM,GLIS3,TNIK,HPSE2,PRKG1,NPAS3,NEBL,CST3,DCLK2,NTRK2,TRPS1,SLC1A2,MGAT4C,CDH20,CTNND2,LSAMP,SORBS1,PARD3,CNTN1,ADCY2,NHSL1,ZBTB20,GJA1,DTNA,TRPM3,GPC5,ATP1A2,FMN2
2.398e-03	-6.03	DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5)	protein interactions	80331	365	5	19454	50	PARD3,MACF1,DTNA,GJA1,CLU
2.480e-03	-6.00	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	32	SLC1A2,SLC1A3
2.484e-03	-6.00	protein kinase C-activating G protein-coupled receptor signaling pathway	biological process	GO:0007205	27	2	18204	50	DGKG,PARD3
2.495e-03	-5.99	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	6	16828	48	TNIK,PRKG1,ERBB4,NTRK2,DCLK2,MACF1
2.507e-03	-5.99	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	31	16828	48	LSAMP,CTNND2,RFX4,CDH20,ADCY2,NHSL1,CNTN1,PARD3,NKAIN3,GPC5,FMN2,CLU,NRG3,RYR3,DGKG,SLC1A3,ERBB4,GLIS3,LRP1B,GPM6A,MACF1,TNC,RORA,SOX5,PRKG1,NEBL,TNIK,HPSE2,SLC1A2,MGAT4C,NTRK2
2.514e-03	-5.99	PLEKHA6 (pleckstrin homology domain containing A6)	protein interactions	22874	29	2	19454	50	PARD3,APOE
2.559e-03	-5.97	USP6NL (USP6 N-terminal like)	protein interactions	9712	106	3	19454	50	GJA1,NTRK2,PARD3
2.564e-03	-5.97	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	49	CLU
2.570e-03	-5.96	Cntnap2 (contactin associated protein-like 2)	protein interactions	66797	1	1	19454	50	CNTN1
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Itga7 (integrin subunit alpha 7)	protein interactions	81008	1	1	19454	50	TNC
2.570e-03	-5.96	App (amyloid beta precursor protein)	protein interactions	100689222	1	1	19454	50	LRP1B
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.573e-03	-5.96	circulatory system process	biological process	GO:0003013	508	6	18204	50	APOE,ATP1A2,SLC1A2,PRKG1,GJA1,SLC1A3
2.585e-03	-5.96	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	11	16828	48	SLC14A1,GPC5,DTNA,NPAS3,FMN2,NRG3,RYR3,DGKG,LRP1B,MACF1,SORBS1
2.614e-03	-5.95	response to alkaloid	biological process	GO:0043279	100	3	18204	50	SLC1A3,SLC1A2,RYR3
2.625e-03	-5.94	non_seminoma	COSMIC cancer mutations	non_seminoma	492	6	16828	48	PRKG1,ERBB4,MACF1,TNIK,DCLK2,NTRK2
2.643e-03	-5.94	regulation of localization	biological process	GO:0032879	2028	13	18204	50	DCLK2,CNTN1,SLC1A2,PRKG1,SORBS1,RYR3,GJA1,ERBB4,CLU,APOE,ATP1A2,NKAIN3,GPC5
2.653e-03	-5.93	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	48	NTRK2
2.653e-03	-5.93	metal chelating activity	molecular function	GO:0046911	1	1	18094	48	APOE
2.670e-03	-5.93	glial cell proliferation	biological process	GO:0014009	28	2	18204	50	NFIA,CLU
2.670e-03	-5.93	water transport	biological process	GO:0006833	28	2	18204	50	AQP4,SLC14A1
2.673e-03	-5.92	lipoprotein particle receptor binding	molecular function	GO:0070325	29	2	18094	48	CLU,APOE
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A3,SLC1A2
2.677e-03	-5.92	central_nervous_system-brainstem-glioma	COSMIC cancer mutations	central_nervous_system-brainstem-glioma	338	5	16828	48	ERBB4,TNC,HPSE2,GPC5,LRP1B
2.691e-03	-5.92	Nuclear signaling by ERBB4	REACTOME pathways	R-HSA-1251985	25	2	10285	32	ERBB4,NRG3
2.698e-03	-5.92	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	3	19454	50	RYR3,MSI2,ERBB4
2.698e-03	-5.92	response to oxygen-containing compound	biological process	GO:1901700	1546	11	18204	50	ATP1A2,SLC1A2,APOE,RORA,SLC1A3,TNC,ADCY2,ZBTB20,GJA1,RYR3,SORBS1
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	PKcGMP_CC	interpro domains	IPR031831	1	1	18521	50	PRKG1
2.700e-03	-5.91	Contactin-1_Ig6	interpro domains	IPR047101	1	1	18521	50	CNTN1
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.700e-03	-5.91	Connexin43	interpro domains	IPR002261	1	1	18521	50	GJA1
2.700e-03	-5.91	Alpha_helix_dom_sf	interpro domains	IPR035091	1	1	18521	50	GJA1
2.700e-03	-5.91	Contactin-1_Ig1	interpro domains	IPR036992	1	1	18521	50	CNTN1
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	C1_DGKgamma_rpt2	interpro domains	IPR047475	1	1	18521	50	DGKG
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	Contactin-1_Ig3	interpro domains	IPR047100	1	1	18521	50	CNTN1
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	Connexin43_C	interpro domains	IPR013124	1	1	18521	50	GJA1
2.730e-03	-5.90	Kinase-like_dom_sf	interpro domains	IPR011009	523	6	18521	50	PRKG1,MAPK10,TNIK,NTRK2,ERBB4,DCLK2
2.747e-03	-5.90	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	50	CST3
2.747e-03	-5.90	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	50	CLU
2.747e-03	-5.90	atrial ventricular junction remodeling	biological process	GO:0003294	1	1	18204	50	GJA1
2.747e-03	-5.90	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	50	FMN2
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	50	NTRK2
2.747e-03	-5.90	regulation of transport across blood-brain barrier	biological process	GO:0150200	1	1	18204	50	APOE
2.747e-03	-5.90	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	50	CST3
2.747e-03	-5.90	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	50	CLU
2.747e-03	-5.90	positive regulation of heparan sulfate proteoglycan binding	biological process	GO:1905860	1	1	18204	50	APOE
2.747e-03	-5.90	milk ejection reflex	biological process	GO:0060156	1	1	18204	50	GJA1
2.747e-03	-5.90	positive regulation of lipid transport across blood-brain barrier	biological process	GO:1903002	1	1	18204	50	APOE
2.747e-03	-5.90	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	50	NRG3
2.747e-03	-5.90	regulation of cellular response to very-low-density lipoprotein particle stimulus	biological process	GO:1905890	1	1	18204	50	APOE
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.747e-03	-5.90	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	50	NTRK2
2.747e-03	-5.90	intermediate-density lipoprotein particle clearance	biological process	GO:0071831	1	1	18204	50	APOE
2.747e-03	-5.90	positive regulation of transport across blood-brain barrier	biological process	GO:0150201	1	1	18204	50	APOE
2.747e-03	-5.90	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	50	NRG3
2.747e-03	-5.90	regulation of lipid transport across blood-brain barrier	biological process	GO:1903000	1	1	18204	50	APOE
2.747e-03	-5.90	regulation of heparan sulfate proteoglycan binding	biological process	GO:1905858	1	1	18204	50	APOE
2.754e-03	-5.89	PKcGMP_CC	pfam domains	PF16808	1	1	17795	49	PRKG1
2.754e-03	-5.89	Connexin43	pfam domains	PF03508	1	1	17795	49	GJA1
2.819e-03	-5.87	VANGL1 (VANGL planar cell polarity protein 1)	protein interactions	81839	229	4	19454	50	GJA1,NTRK2,ERBB4,PARD3
2.843e-03	-5.86	cerebellum development	biological process	GO:0021549	103	3	18204	50	RORA,PRKG1,CNTN1
2.857e-03	-5.86	cell body	cellular component	GO:0044297	556	6	19108	49	ATP1A2,SLC1A3,SLC1A2,CTNND2,APOE,GPM6A
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CTNNA2,CDH20
2.863e-03	-5.86	cGMP-mediated signaling	biological process	GO:0019934	29	2	18204	50	APOE,PRKG1
2.863e-03	-5.86	myelination in peripheral nervous system	biological process	GO:0022011	29	2	18204	50	NTRK2,PARD3
2.863e-03	-5.86	peripheral nervous system axon ensheathment	biological process	GO:0032292	29	2	18204	50	NTRK2,PARD3
2.870e-03	-5.85	SH2B1 (SH2B adaptor protein 1)	protein interactions	25970	31	2	19454	50	NTRK2,ERBB4
2.897e-03	-5.84	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	8	16828	48	ERBB4,PRKG1,TNIK,CNTN1,MACF1,TRPS1,DCLK2,NTRK2
2.922e-03	-5.84	regulation of steroid metabolic process	biological process	GO:0019218	104	3	18204	50	RORA,APOE,PRKG1
2.972e-03	-5.82	Connexin43	gene3d domains	1.20.5.1130	1	1	14470	43	GJA1
2.972e-03	-5.82	-	gene3d domains	6.10.250.880	1	1	14470	43	ERBB4
2.978e-03	-5.82	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	6	19454	50	PARD3,SLC1A3,MACF1,FMN2,DTNA,GJA1
2.991e-03	-5.81	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	3	19454	50	TRPS1,NFIA,SOX5
3.002e-03	-5.81	neural precursor cell proliferation	biological process	GO:0061351	105	3	18204	50	SOX5,RORA,NFIA
3.017e-03	-5.80	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	6	16828	48	ZBTB20,PRKG1,NPAS3,TNC,MGAT4C,SLC14A1
3.041e-03	-5.80	positive regulation of cell projection organization	biological process	GO:0031346	361	5	18204	50	MACF1,CNTN1,GPM6A,NTRK2,APOE
3.055e-03	-5.79	CDH1 (cadherin 1)	protein interactions	999	757	7	19454	50	CTNNA2,CTNND2,PARD3,NEBL,SORBS1,NHSL1,MACF1
3.062e-03	-5.79	L-glutamate import	biological process	GO:0051938	30	2	18204	50	SLC1A3,SLC1A2
3.076e-03	-5.78	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	6	14470	43	MAPK10,NTRK2,PRKG1,TNIK,DCLK2,ERBB4
3.111e-03	-5.77	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	REACTOME pathways	R-HSA-190840	1	1	10285	32	GJA1
3.145e-03	-5.76	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	47	16828	48	CDH20,LSAMP,ADCY2,NHSL1,SORBS1,NKAIN3,PARD3,PITPNC1,DTNA,GPC5,TRPM3,ZBTB20,NRG3,RYR3,ERBB4,LRP1B,GLIS3,TNC,MACF1,TNIK,PRKG1,NPAS3,DCLK2,NTRK2,TRPS1,NFIA,CTNND2,RFX4,CNTN1,GJA1,FMN2,ATP1A2,CLU,DGKG,SLC1A3,GPM6A,NTM,SOX5,APOE,RORA,CST3,SLC14A1,HPSE2,NEBL,AQP4,SLC1A2,MGAT4C
3.152e-03	-5.76	kinase activity	molecular function	GO:0016301	739	7	18094	48	PRKG1,NTRK2,DCLK2,ERBB4,MAPK10,DGKG,TNIK
3.188e-03	-5.75	CLU (clusterin)	protein interactions	1191	237	4	19454	50	LRP1B,CLU,TNC,TNIK
3.202e-03	-5.74	presynapse	cellular component	GO:0098793	569	6	19108	49	ERBB4,NTRK2,CNTN1,SLC1A2,TNIK,GPM6A
3.222e-03	-5.74	DTNA (dystrobrevin alpha)	protein interactions	1837	115	3	19454	50	PARD3,GJA1,NTRK2
3.249e-03	-5.73	VLDLR (very low density lipoprotein receptor)	protein interactions	7436	33	2	19454	50	CLU,APOE
3.259e-03	-5.73	caecum	COSMIC cancer mutations	caecum	14248	47	16828	48	ERBB4,RYR3,NRG3,MACF1,TNC,GLIS3,LRP1B,PRKG1,NPAS3,TNIK,TRPS1,DCLK2,NTRK2,LSAMP,CDH20,PARD3,SORBS1,NKAIN3,ADCY2,NHSL1,ZBTB20,DTNA,GPC5,TRPM3,PITPNC1,DGKG,SLC1A3,CLU,RORA,SOX5,APOE,GPM6A,NTM,AQP4,NEBL,HPSE2,SLC14A1,CST3,SLC1A2,MGAT4C,CTNND2,RFX4,NFIA,CNTN1,GJA1,ATP1A2,FMN2
3.329e-03	-5.71	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	10	16828	48	TRPM3,ZBTB20,NPAS3,ERBB4,NTM,LRP1B,SORBS1,ATP1A2,TRPS1,MACF1
3.336e-03	-5.70	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	6	19454	50	ERBB4,GJA1,MACF1,TNIK,DTNA,PARD3
3.385e-03	-5.69	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	4	19454	50	GJA1,NTRK2,PARD3,CTNND2
3.401e-03	-5.68	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	5	18521	50	ERBB4,PRKG1,DCLK2,TNIK,NTRK2
3.441e-03	-5.67	HAX1 (HCLS1 associated protein X-1)	protein interactions	10456	397	5	19454	50	CNTN1,NTM,GPM6A,MAPK10,CLU
3.446e-03	-5.67	ErbB signaling pathway	KEGG pathways	ko04012	85	3	7161	26	ERBB4,MAPK10,NRG3
3.446e-03	-5.67	ErbB signaling pathway	KEGG pathways	hsa04012	85	3	7161	26	ERBB4,NRG3,MAPK10
3.472e-03	-5.66	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	7	18094	48	GJA1,GPM6A,ATP1A2,RYR3,SLC1A2,TRPM3,SLC1A3
3.479e-03	-5.66	transepithelial transport	biological process	GO:0070633	32	2	18204	50	SLC1A2,SLC1A3
3.482e-03	-5.66	cell adhesion molecule binding	molecular function	GO:0050839	560	6	18094	48	CDH20,CTNND2,CNTN1,CTNNA2,TNC,MACF1
3.485e-03	-5.66	seminoma	COSMIC cancer mutations	seminoma	700	7	16828	48	TNIK,ERBB4,PRKG1,CNTN1,NTRK2,DCLK2,TRPS1
3.529e-03	-5.65	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	43	CLU
3.529e-03	-5.65	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	43	CLU
3.548e-03	-5.64	ANKRD26 (ankyrin repeat domain containing 26)	protein interactions	22852	119	3	19454	50	PARD3,NTRK2,GJA1
3.578e-03	-5.63	phosphorylation	biological process	GO:0016310	729	7	18204	50	ERBB4,TNIK,DCLK2,MAPK10,PRKG1,NTRK2,DGKG
3.602e-03	-5.63	DELLA	smart domains	SM01129	1	1	9717	35	MACF1
3.662e-03	-5.61	amide transmembrane transporter activity	molecular function	GO:0042887	34	2	18094	48	SLC14A1,GJA1
3.688e-03	-5.60	calcium channel activity	molecular function	GO:0005262	117	3	18094	48	GPM6A,RYR3,TRPM3
3.692e-03	-5.60	dendrite development	biological process	GO:0016358	113	3	18204	50	CTNND2,PRKG1,CTNNA2
3.692e-03	-5.60	metencephalon development	biological process	GO:0022037	113	3	18204	50	RORA,PRKG1,CNTN1
3.697e-03	-5.60	response to auditory stimulus	biological process	GO:0010996	33	2	18204	50	SLC1A3,ATP1A2
3.749e-03	-5.59	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	4	19454	50	DGKG,TNIK,NFIA,SOX5
3.775e-03	-5.58	arm	COSMIC cancer mutations	arm	1331	10	16828	48	TRPM3,ZBTB20,NPAS3,ERBB4,NTM,LRP1B,SORBS1,ATP1A2,TRPS1,MACF1
3.785e-03	-5.58	regulation of circadian rhythm	biological process	GO:0042752	114	3	18204	50	PRKG1,MAPK10,RORA
3.801e-03	-5.57	Gap junction	KEGG pathways	ko04540	88	3	7161	26	PRKG1,ADCY2,GJA1
3.801e-03	-5.57	Gap junction	KEGG pathways	hsa04540	88	3	7161	26	GJA1,PRKG1,ADCY2
3.826e-03	-5.57	CONNEXINA1	prints domains	PR01132	1	1	5227	20	GJA1
3.826e-03	-5.57	AQUAPORIN4	prints domains	PR02016	1	1	5227	20	AQP4
3.826e-03	-5.57	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	20	NTRK2
3.839e-03	-5.56	lipoprotein particle	cellular component	GO:1990777	36	2	19108	49	CLU,APOE
3.839e-03	-5.56	plasma lipoprotein particle	cellular component	GO:0034358	36	2	19108	49	APOE,CLU
3.857e-03	-5.56	PTPRB (protein tyrosine phosphatase receptor type B)	protein interactions	5787	36	2	19454	50	TNC,CNTN1
3.864e-03	-5.56	Downregulation of ERBB2 signaling	REACTOME pathways	R-HSA-8863795	30	2	10285	32	NRG3,ERBB4
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A3,SLC1A2
3.904e-03	-5.55	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	12	16828	48	ZBTB20,HPSE2,TRPM3,NTRK2,SLC1A2,FMN2,DGKG,NRG3,RFX4,SOX5,CNTN1,NHSL1
3.904e-03	-5.55	functioning	COSMIC cancer mutations	functioning	1803	12	16828	48	NTRK2,FMN2,SLC1A2,HPSE2,ZBTB20,TRPM3,SOX5,CNTN1,NHSL1,DGKG,NRG3,RFX4
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	CNTN1,NTM,LSAMP,NTRK2
3.921e-03	-5.54	exploration behavior	biological process	GO:0035640	34	2	18204	50	APOE,ATP1A2
4.012e-03	-5.52	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	9	16828	48	LRP1B,MGAT4C,RORA,NTRK2,CTNND2,RYR3,ERBB4,PRKG1,TNIK
4.031e-03	-5.51	protein kinase activity	molecular function	GO:0004672	577	6	18094	48	TNIK,DCLK2,NTRK2,ERBB4,MAPK10,PRKG1
4.052e-03	-5.51	glial cell projection	cellular component	GO:0097386	37	2	19108	49	SLC1A2,AQP4
4.052e-03	-5.51	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	42	16828	48	SLC1A2,MGAT4C,TRPS1,DCLK2,NTRK2,CST3,PRKG1,NPAS3,NEBL,TNIK,HPSE2,GLIS3,LRP1B,GPM6A,NTM,MACF1,TNC,RORA,SOX5,RYR3,NRG3,SLC1A3,DGKG,ERBB4,FMN2,ATP1A2,DTNA,GPC5,TRPM3,PITPNC1,GJA1,ZBTB20,ADCY2,NHSL1,CNTN1,PARD3,SORBS1,CTNND2,LSAMP,RFX4,CDH20,NFIA
4.068e-03	-5.50	large_intestine-caecum-adenoma	COSMIC cancer mutations	large_intestine-caecum-adenoma	229	4	16828	48	ERBB4,HPSE2,CTNND2,LRP1B
4.071e-03	-5.50	MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2)	protein interactions	9863	37	2	19454	50	ERBB4,CTNND2
4.071e-03	-5.50	HPCA (hippocalcin)	protein interactions	3208	37	2	19454	50	GPM6A,CST3
4.071e-03	-5.50	PRRG4 (proline rich and Gla domain 4)	protein interactions	79056	37	2	19454	50	ERBB4,NEBL
4.093e-03	-5.50	cervix	COSMIC cancer mutations	cervix	11793	42	16828	48	NHSL1,ADCY2,CNTN1,PARD3,SORBS1,RFX4,CTNND2,LSAMP,NFIA,CDH20,FMN2,ATP1A2,GPC5,TRPM3,DTNA,PITPNC1,GJA1,ZBTB20,GLIS3,NTM,LRP1B,GPM6A,TNC,RORA,MACF1,SOX5,NRG3,RYR3,DGKG,ERBB4,SLC1A3,MGAT4C,SLC1A2,TRPS1,NTRK2,DCLK2,CST3,NPAS3,NEBL,PRKG1,HPSE2,TNIK
4.096e-03	-5.50	muscle contraction	biological process	GO:0006936	238	4	18204	50	DTNA,GJA1,RYR3,ATP1A2
4.169e-03	-5.48	synapse assembly	biological process	GO:0007416	118	3	18204	50	NRG3,ERBB4,GPM6A
4.196e-03	-5.47	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	3	16828	48	SOX5,SLC1A2,RYR3
4.245e-03	-5.46	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	8	16828	48	SORBS1,MACF1,TNC,MGAT4C,LRP1B,ADCY2,ERBB4,CTNND2
4.258e-03	-5.46	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	3	19454	50	DTNA,MACF1,PARD3
4.290e-03	-5.45	MMP3 (matrix metallopeptidase 3)	protein interactions	4314	38	2	19454	50	CLU,APOE
4.342e-03	-5.44	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	6	16828	48	TNIK,ERBB4,PRKG1,FMN2,NTRK2,DCLK2
4.380e-03	-5.43	cellular response to chemical stimulus	biological process	GO:0070887	2411	14	18204	50	ZBTB20,TNC,APOE,AQP4,ATP1A2,GJA1,SORBS1,FMN2,RYR3,ADCY2,SLC1A3,RORA,NTRK2,SLC1A2
4.380e-03	-5.43	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	6	16828	48	PRKG1,ERBB4,NTRK2,TNIK,DCLK2,FMN2
4.404e-03	-5.43	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	9	16828	48	CTNND2,RYR3,ERBB4,PRKG1,TNIK,LRP1B,MGAT4C,RORA,NTRK2
4.455e-03	-5.41	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	6	18094	48	ATP1A2,RYR3,GPM6A,SLC1A3,SLC1A2,TRPM3
4.487e-03	-5.41	testis	COSMIC cancer mutations	testis	733	7	16828	48	PRKG1,ERBB4,TNIK,TRPS1,MACF1,DCLK2,NTRK2
4.493e-03	-5.41	protein-lipid complex	cellular component	GO:0032994	39	2	19108	49	APOE,CLU
4.494e-03	-5.41	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	4	19454	50	MACF1,DTNA,FMN2,PARD3
4.500e-03	-5.40	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	18	16828	48	DGKG,ERBB4,CTNND2,RFX4,NRG3,MACF1,TNC,PARD3,ADCY2,GLIS3,LRP1B,NEBL,TRPM3,GPC5,PITPNC1,ATP1A2,MGAT4C,FMN2
4.603e-03	-5.38	organic anion transport	biological process	GO:0015711	398	5	18204	50	GJA1,APOE,NTRK2,SLC1A2,SLC1A3
4.605e-03	-5.38	regulation of synapse organization	biological process	GO:0050807	246	4	18204	50	NTRK2,CTNNA2,APOE,GPM6A
4.631e-03	-5.38	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	50	SLC1A2,SORBS1
4.696e-03	-5.36	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	40	16828	48	PARD3,SORBS1,ADCY2,NHSL1,CNTN1,CTNND2,LSAMP,CDH20,ATP1A2,FMN2,GJA1,ZBTB20,DTNA,TRPM3,GPC5,MSI2,RORA,TNC,MACF1,SOX5,GLIS3,LRP1B,NTM,SLC1A3,DGKG,ERBB4,CLU,NRG3,RYR3,TRPS1,DCLK2,NTRK2,SLC1A2,MGAT4C,PRKG1,NPAS3,NEBL,TNIK,HPSE2,CST3
4.744e-03	-5.35	SHC2 (SHC adaptor protein 2)	protein interactions	25759	40	2	19454	50	NTRK2,ERBB4
4.751e-03	-5.35	regulation of cell growth	biological process	GO:0001558	401	5	18204	50	APOE,NRG3,GJA1,MACF1,TNC
4.788e-03	-5.34	positive regulation of lipid metabolic process	biological process	GO:0045834	124	3	18204	50	ZBTB20,APOE,SORBS1
4.788e-03	-5.34	action potential	biological process	GO:0001508	124	3	18204	50	ATP1A2,GJA1,NTRK2
4.855e-03	-5.33	Circadian entrainment	KEGG pathways	ko04713	96	3	7161	26	RYR3,PRKG1,ADCY2
4.855e-03	-5.33	Circadian entrainment	KEGG pathways	hsa04713	96	3	7161	26	RYR3,ADCY2,PRKG1
4.880e-03	-5.32	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	50	SLC1A3,SLC1A2
4.880e-03	-5.32	fluid transport	biological process	GO:0042044	38	2	18204	50	AQP4,SLC14A1
4.897e-03	-5.32	mammary gland development	biological process	GO:0030879	125	3	18204	50	ERBB4,GJA1,NRG3
4.945e-03	-5.31	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	3	19454	50	NTM,GPM6A,CNTN1
4.969e-03	-5.30	intracellular chemical homeostasis	biological process	GO:0055082	581	6	18204	50	SLC1A3,ATP1A2,RYR3,ZBTB20,APOE,AQP4
4.980e-03	-5.30	RASSF7 (Ras association domain family member 7)	protein interactions	8045	41	2	19454	50	CLU,PARD3
5.014e-03	-5.30	regulation of synapse structure or activity	biological process	GO:0050803	252	4	18204	50	GPM6A,NTRK2,CTNNA2,APOE
5.118e-03	-5.28	cell-cell junction assembly	biological process	GO:0007043	127	3	18204	50	PARD3,CDH20,GJA1
5.122e-03	-5.27	discoidal high-density lipoprotein particle	cellular component	GO:0034365	2	1	19108	49	APOE
5.122e-03	-5.27	chylomicron remnant	cellular component	GO:0034360	2	1	19108	49	APOE
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	DTNA,RYR3,DGKG,MACF1
5.127e-03	-5.27	RHOB (ras homolog family member B)	protein interactions	388	832	7	19454	50	TNIK,MACF1,FMN2,DTNA,SLC1A3,GJA1,PARD3
5.134e-03	-5.27	THSD1 (thrombospondin type 1 domain containing 1)	protein interactions	55901	2	1	19454	50	GJA1
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	TRIM39-RPP21 (TRIM39-RPP21 readthrough)	protein interactions	202658	2	1	19454	50	PRKG1
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	DEFB126 (defensin beta 126)	protein interactions	81623	2	1	19454	50	GJA1
5.134e-03	-5.27	cdh11.S (cadherin 11 S homeolog)	protein interactions	100337621	2	1	19454	50	ERBB4
5.134e-03	-5.27	positive regulation of nitric oxide biosynthetic process	biological process	GO:0045429	39	2	18204	50	CLU,APOE
5.134e-03	-5.27	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	50	ATP1A2,SLC1A3
5.134e-03	-5.27	lactation	biological process	GO:0007595	39	2	18204	50	ERBB4,GJA1
5.134e-03	-5.27	olfactory lobe development	biological process	GO:0021988	39	2	18204	50	ERBB4,ATP1A2
5.259e-03	-5.25	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	3	19454	50	NFIA,SOX5,DGKG
5.299e-03	-5.24	cGMP-dependent protein kinase activity	molecular function	GO:0004692	2	1	18094	48	PRKG1
5.299e-03	-5.24	heparanase activity	molecular function	GO:0030305	2	1	18094	48	HPSE2
5.299e-03	-5.24	protein complex oligomerization	biological process	GO:0051259	256	4	18204	50	SLC1A2,AQP4,TRPM3,RYR3
5.347e-03	-5.23	large_intestine-rectum	COSMIC cancer mutations	large_intestine-rectum	569	6	16828	48	ADCY2,CNTN1,FMN2,TRPS1,PRKG1,ERBB4
5.366e-03	-5.23	NFIB (nuclear factor I B)	protein interactions	4781	138	3	19454	50	NFIA,TRPS1,SOX5
5.373e-03	-5.23	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	11	18204	50	RORA,SOX5,APOE,NTRK2,MACF1,ATP1A2,GJA1,ZBTB20,CLU,PARD3,ERBB4
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	Glyco_hydro_79	interpro domains	IPR005199	2	1	18521	50	HPSE2
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Urea_transporter	interpro domains	IPR004937	2	1	18521	50	SLC14A1
5.392e-03	-5.22	LRP1-like_beta_prop	interpro domains	IPR032485	2	1	18521	50	LRP1B
5.392e-03	-5.22	Contactin-1_2_Ig1	interpro domains	IPR047102	2	1	18521	50	CNTN1
5.392e-03	-5.22	Par3/HAL_N	interpro domains	IPR021922	2	1	18521	50	PARD3
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	cGMP_dep_kinase	interpro domains	IPR002374	2	1	18521	50	PRKG1
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.392e-03	-5.22	STKc_cGK	interpro domains	IPR035014	2	1	18521	50	PRKG1
5.395e-03	-5.22	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	2	18204	50	RORA,ADCY2
5.395e-03	-5.22	positive regulation of nitric oxide metabolic process	biological process	GO:1904407	40	2	18204	50	APOE,CLU
5.466e-03	-5.21	GPRIN3 (GPRIN family member 3)	protein interactions	285513	43	2	19454	50	NTRK2,GJA1
5.466e-03	-5.21	C2CD4B (C2 calcium dependent domain containing 4B)	protein interactions	388125	43	2	19454	50	MACF1,LRP1B
5.486e-03	-5.21	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	50	CST3
5.486e-03	-5.21	lipid transport involved in lipid storage	biological process	GO:0010877	2	1	18204	50	APOE
5.486e-03	-5.21	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	50	CST3
5.486e-03	-5.21	negative regulation of inositol phosphate biosynthetic process	biological process	GO:0010920	2	1	18204	50	PRKG1
5.486e-03	-5.21	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	50	CLU
5.486e-03	-5.21	establishment of planar polarity involved in nephron morphogenesis	biological process	GO:0072046	2	1	18204	50	ERBB4
5.486e-03	-5.21	mesenchymal-epithelial cell signaling involved in prostate gland development	biological process	GO:0060739	2	1	18204	50	TNC
5.500e-03	-5.20	Par3_HAL_N_term	pfam domains	PF12053	2	1	17795	49	PARD3
5.500e-03	-5.20	DUF5050	pfam domains	PF16472	2	1	17795	49	LRP1B
5.500e-03	-5.20	Glyco_hydro_79n	pfam domains	PF03662	2	1	17795	49	HPSE2
5.500e-03	-5.20	UT	pfam domains	PF03253	2	1	17795	49	SLC14A1
5.500e-03	-5.20	Clusterin	pfam domains	PF01093	2	1	17795	49	CLU
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A2,SLC1A3
5.576e-03	-5.19	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	7	16828	48	NTRK2,DCLK2,LRP1B,PRKG1,ERBB4,TNIK,CDH20
5.576e-03	-5.19	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	7	16828	48	CDH20,TNIK,ERBB4,PRKG1,LRP1B,NTRK2,DCLK2
5.611e-03	-5.18	TJP2 (tight junction protein 2)	protein interactions	9414	278	4	19454	50	GJA1,SORBS1,NEBL,PARD3
5.612e-03	-5.18	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	48	RYR3,GPM6A,TRPM3
5.614e-03	-5.18	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	15	16828	48	TRPM3,NPAS3,AQP4,FMN2,CTNND2,RYR3,NFIA,ADCY2,GLIS3,LRP1B,MACF1,TNC,RORA,APOE,SORBS1
5.614e-03	-5.18	embryonal	COSMIC cancer mutations	embryonal	2659	15	16828	48	FMN2,TRPM3,NPAS3,AQP4,ADCY2,GLIS3,LRP1B,RORA,MACF1,TNC,APOE,SORBS1,CTNND2,NFIA,RYR3
5.662e-03	-5.17	cyclic nucleotide metabolic process	biological process	GO:0009187	41	2	18204	50	RORA,ADCY2
5.681e-03	-5.17	leg	COSMIC cancer mutations	leg	969	8	16828	48	LRP1B,CNTN1,FMN2,NTM,ZBTB20,PRKG1,NEBL,NRG3
5.692e-03	-5.17	actin binding	molecular function	GO:0003779	434	5	18094	48	FMN2,SORBS1,CTNNA2,MACF1,NEBL
5.696e-03	-5.17	LLGL1 (LLGL scribble cell polarity complex component 1)	protein interactions	3996	141	3	19454	50	NTRK2,GJA1,PARD3
5.696e-03	-5.17	ARHGAP32 (Rho GTPase activating protein 32)	protein interactions	9743	141	3	19454	50	NTRK2,GJA1,PARD3
5.704e-03	-5.17	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	43	16828	48	NTRK2,TRPS1,MGAT4C,SLC1A2,HPSE2,TNIK,AQP4,NEBL,NPAS3,PRKG1,SLC14A1,SOX5,MACF1,RORA,TNC,NTM,GPM6A,LRP1B,GLIS3,DGKG,SLC1A3,ERBB4,NRG3,RYR3,CLU,ATP1A2,FMN2,ZBTB20,GJA1,PITPNC1,TRPM3,GPC5,NKAIN3,SORBS1,PARD3,CNTN1,NHSL1,ADCY2,NFIA,CDH20,RFX4,LSAMP,CTNND2
5.717e-03	-5.16	SDK2 (sidekick cell adhesion molecule 2)	protein interactions	54549	44	2	19454	50	CLU,GJA1
5.717e-03	-5.16	SH2D1A (SH2 domain containing 1A)	protein interactions	4068	44	2	19454	50	ERBB4,LRP1B
5.766e-03	-5.16	axon development	biological process	GO:0061564	420	5	18204	50	PARD3,CNTN1,TNC,CTNNA2,PRKG1
5.806e-03	-5.15	tau protein binding	molecular function	GO:0048156	43	2	18094	48	CLU,APOE
5.922e-03	-5.13	SLC6A15 (solute carrier family 6 member 15)	protein interactions	55117	143	3	19454	50	PARD3,NTRK2,GJA1
5.934e-03	-5.13	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	18	16828	48	TRPM3,GPC5,ZBTB20,HPSE2,NPAS3,PRKG1,FMN2,DCLK2,ATP1A2,RYR3,CTNND2,DGKG,ERBB4,CNTN1,LRP1B,ADCY2,PARD3,MACF1
5.935e-03	-5.13	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	43	CTNNA2
5.935e-03	-5.13	-	gene3d domains	6.20.350.10	2	1	14470	43	RYR3
5.935e-03	-5.13	Schwann cell development	biological process	GO:0014044	42	2	18204	50	PARD3,NTRK2
5.935e-03	-5.13	triglyceride homeostasis	biological process	GO:0070328	42	2	18204	50	RORA,APOE
5.935e-03	-5.13	regulation of amino acid transport	biological process	GO:0051955	42	2	18204	50	ATP1A2,PRKG1
5.939e-03	-5.13	regulation of growth	biological process	GO:0040008	603	6	18204	50	MACF1,TNC,ERBB4,GJA1,NRG3,APOE
5.939e-03	-5.13	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	10	16828	48	LRP1B,ADCY2,PARD3,NRG3,RYR3,GPC5,TRPM3,HPSE2,ERBB4,PRKG1
5.946e-03	-5.12	spleen	COSMIC cancer mutations	spleen	408	5	16828	48	LRP1B,NTM,ADCY2,TNIK,SORBS1
5.998e-03	-5.12	cellular response to organic substance	biological process	GO:0071310	1716	11	18204	50	ZBTB20,GJA1,SORBS1,RYR3,SLC1A3,TNC,ADCY2,AQP4,RORA,ATP1A2,SLC1A2
5.998e-03	-5.12	developmental growth	biological process	GO:0048589	424	5	18204	50	GJA1,PRKG1,SLC1A2,TNC,ERBB4
5.998e-03	-5.12	growth	biological process	GO:0040007	424	5	18204	50	GJA1,PRKG1,SLC1A2,ERBB4,TNC
6.031e-03	-5.11	response to organic substance	biological process	GO:0010033	2498	14	18204	50	ZBTB20,TNC,AQP4,ATP1A2,GJA1,SORBS1,RYR3,CLU,ADCY2,SLC1A3,RORA,NTRK2,SLC1A2,TNIK
6.037e-03	-5.11	USP8 (ubiquitin specific peptidase 8)	protein interactions	9101	144	3	19454	50	NTRK2,ERBB4,GJA1
6.090e-03	-5.10	monoatomic ion transmembrane transport	biological process	GO:0034220	804	7	18204	50	GJA1,RYR3,TRPM3,SLC1A3,SLC1A2,GPM6A,ATP1A2
6.117e-03	-5.10	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	10	16828	48	FMN2,SLC1A2,NHSL1,NTRK2,ATP1A2,NFIA,CLU,PITPNC1,RFX4,CTNND2
6.117e-03	-5.10	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	10	16828	48	NFIA,PITPNC1,CLU,RFX4,CTNND2,FMN2,SLC1A2,NHSL1,NTRK2,ATP1A2
6.159e-03	-5.09	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	6	18094	48	RYR3,ATP1A2,GPM6A,SLC1A3,TRPM3,SLC1A2
6.213e-03	-5.08	Transport of connexons to the plasma membrane	REACTOME pathways	R-HSA-190872	2	1	10285	32	GJA1
6.213e-03	-5.08	acylglycerol homeostasis	biological process	GO:0055090	43	2	18204	50	APOE,RORA
6.234e-03	-5.08	EXTL2 (exostosin like glycosyltransferase 2)	protein interactions	2135	46	2	19454	50	MGAT4C,CLU
6.288e-03	-5.07	basal plasma membrane	cellular component	GO:0009925	288	4	19108	49	SLC1A3,ERBB4,SLC14A1,AQP4
6.400e-03	-5.05	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	6	12186	43	ERBB4,NTRK2,PRKG1,DCLK2,MAPK10,TNIK
6.420e-03	-5.05	trans-synaptic signaling	biological process	GO:0099537	431	5	18204	50	SLC1A3,SLC1A2,APOE,DTNA,NTRK2
6.498e-03	-5.04	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	50	SLC1A2,SORBS1
6.500e-03	-5.04	LRIG3 (leucine rich repeats and immunoglobulin like domains 3)	protein interactions	121227	47	2	19454	50	GJA1,ERBB4
6.574e-03	-5.02	actin filament-based process	biological process	GO:0030029	616	6	18204	50	NEBL,FMN2,SORBS1,GJA1,PRKG1,TNIK
6.590e-03	-5.02	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	20	16828	48	GPC5,TRPM3,DTNA,AQP4,PRKG1,TNIK,TRPS1,ATP1A2,CTNND2,LSAMP,RYR3,NFIA,ERBB4,DGKG,GLIS3,ADCY2,LRP1B,MACF1,PARD3,SOX5
6.599e-03	-5.02	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	9	19454	50	TRPS1,NFIA,LSAMP,GLIS3,MACF1,GJA1,CLU,SOX5,MSI2
6.634e-03	-5.02	GSE1 (Gse1 coiled-coil protein)	protein interactions	23199	149	3	19454	50	TNIK,NFIA,SOX5
6.665e-03	-5.01	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	16	16828	48	FMN2,NTRK2,ATP1A2,TRPM3,NEBL,NPAS3,PRKG1,NTM,LRP1B,CNTN1,ADCY2,MACF1,PARD3,MSI2,NRG3,ERBB4
6.665e-03	-5.01	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	16	16828	48	FMN2,NTRK2,ATP1A2,TRPM3,NEBL,NPAS3,PRKG1,ADCY2,NTM,LRP1B,CNTN1,MACF1,PARD3,MSI2,NRG3,ERBB4
6.702e-03	-5.01	neurotransmitter transport	biological process	GO:0006836	140	3	18204	50	SLC1A2,ATP1A2,SLC1A3
6.728e-03	-5.00	behavior	biological process	GO:0007610	619	6	18204	50	APOE,NTRK2,SLC1A3,ATP1A2,CNTN1,SLC1A2
6.772e-03	-4.99	HTRA1 (HtrA serine peptidase 1)	protein interactions	5654	48	2	19454	50	MGAT4C,APOE
6.788e-03	-4.99	cell communication involved in cardiac conduction	biological process	GO:0086065	45	2	18204	50	GJA1,ATP1A2
6.788e-03	-4.99	negative regulation of blood coagulation	biological process	GO:0030195	45	2	18204	50	PRKG1,APOE
6.853e-03	-4.98	cell-cell signaling	biological process	GO:0007267	822	7	18204	50	NTRK2,DTNA,APOE,SLC1A2,GJA1,TNC,SLC1A3
6.875e-03	-4.98	transmembrane transport	biological process	GO:0055085	1264	9	18204	50	GJA1,RYR3,TRPM3,SLC1A3,SLC14A1,AQP4,SLC1A2,GPM6A,ATP1A2
6.875e-03	-4.98	Ig_3	pfam domains	PF13927	141	3	17795	49	NTM,CNTN1,LSAMP
6.969e-03	-4.97	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	50	SORBS1,ZBTB20,APOE
6.987e-03	-4.96	skin-neck-malignant_melanoma	COSMIC cancer mutations	skin-neck-malignant_melanoma	1223	9	16828	48	CTNND2,GPC5,TRPM3,ERBB4,CNTN1,LRP1B,ADCY2,ATP1A2,TNC
7.059e-03	-4.95	nitrogen compound transport	biological process	GO:0071705	1507	10	18204	50	GJA1,FMN2,CLU,SLC1A3,SLC14A1,APOE,LRP1B,NTRK2,SLC1A2,MACF1
7.064e-03	-4.95	TJP1 (tight junction protein 1)	protein interactions	7082	297	4	19454	50	GJA1,DTNA,NEBL,PARD3
7.084e-03	-4.95	negative regulation of hemostasis	biological process	GO:1900047	46	2	18204	50	APOE,PRKG1
7.135e-03	-4.94	SOX6 (SRY-box transcription factor 6)	protein interactions	55553	153	3	19454	50	TRPS1,NFIA,SOX5
7.150e-03	-4.94	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	27	16828	48	RORA,MACF1,SOX5,NTM,LRP1B,ERBB4,DGKG,RYR3,NRG3,CLU,NTRK2,DCLK2,PRKG1,HPSE2,TNIK,PARD3,ADCY2,CNTN1,RFX4,CTNND2,NFIA,ATP1A2,FMN2,ZBTB20,TRPM3,GPC5,PITPNC1
7.150e-03	-4.94	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	27	16828	48	ERBB4,DGKG,RYR3,NRG3,CLU,RORA,MACF1,SOX5,NTM,LRP1B,PRKG1,HPSE2,TNIK,NTRK2,DCLK2,RFX4,CTNND2,NFIA,PARD3,ADCY2,CNTN1,ZBTB20,GPC5,TRPM3,PITPNC1,ATP1A2,FMN2
7.191e-03	-4.93	CLb	smart domains	SM00030	2	1	9717	35	CLU
7.191e-03	-4.93	CLa	smart domains	SM00035	2	1	9717	35	CLU
7.203e-03	-4.93	SFN (stratifin)	protein interactions	2810	671	6	19454	50	SORBS1,NFIA,MACF1,TNIK,FMN2,PARD3
7.284e-03	-4.92	neck	COSMIC cancer mutations	neck	1231	9	16828	48	CNTN1,LRP1B,ADCY2,ATP1A2,TNC,CTNND2,GPC5,TRPM3,ERBB4
7.295e-03	-4.92	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	48	MGAT4C,MACF1
7.295e-03	-4.92	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	48	MACF1,MGAT4C
7.386e-03	-4.91	regulation of neuron migration	biological process	GO:2001222	47	2	18204	50	CTNNA2,NRG3
7.386e-03	-4.91	Schwann cell differentiation	biological process	GO:0014037	47	2	18204	50	PARD3,NTRK2
7.390e-03	-4.91	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	5	16828	48	PRKG1,ERBB4,DCLK2,TNIK,NTRK2
7.390e-03	-4.91	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	5	16828	48	DCLK2,TNIK,NTRK2,PRKG1,ERBB4
7.542e-03	-4.89	intracellular signaling cassette	biological process	GO:0141124	837	7	18204	50	ADCY2,PRKG1,MAPK10,RYR3,TNIK,ATP1A2,APOE
7.581e-03	-4.88	intercalated disc	cellular component	GO:0014704	51	2	19108	49	ATP1A2,GJA1
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	NHSL1,MACF1
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.639e-03	-4.87	CGMPKINASE	prints domains	PR00104	2	1	5227	20	PRKG1
7.639e-03	-4.87	FORMIN	prints domains	PR00828	2	1	5227	20	FMN2
7.691e-03	-4.87	DEFB124 (defensin beta 124)	protein interactions	245937	3	1	19454	50	GJA1
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Itgb1 (integrin subunit beta 1)	protein interactions	24511	3	1	19454	50	TNC
7.691e-03	-4.87	NRG3 (neuregulin 3)	protein interactions	10718	3	1	19454	50	ERBB4
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.821e-03	-4.85	Signaling by ERBB4	REACTOME pathways	R-HSA-1236394	43	2	10285	32	NRG3,ERBB4
7.821e-03	-4.85	Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME pathways	R-HSA-432040	43	2	10285	32	ADCY2,AQP4
7.825e-03	-4.85	Glutamatergic synapse	KEGG pathways	ko04724	114	3	7161	26	SLC1A2,ADCY2,SLC1A3
7.825e-03	-4.85	Glutamatergic synapse	KEGG pathways	hsa04724	114	3	7161	26	ADCY2,SLC1A3,SLC1A2
7.832e-03	-4.85	response to organic cyclic compound	biological process	GO:0014070	843	7	18204	50	RORA,ATP1A2,SLC1A2,RYR3,SLC1A3,TNC,ADCY2
7.847e-03	-4.85	basal part of cell	cellular component	GO:0045178	307	4	19108	49	SLC14A1,ERBB4,SLC1A3,AQP4
7.847e-03	-4.85	regulation of cell migration	biological process	GO:0030334	1061	8	18204	50	MACF1,APOE,ERBB4,TNC,GJA1,NRG3,CTNNA2,PRKG1
7.909e-03	-4.84	SNAP91 (synaptosome associated protein 91)	protein interactions	9892	52	2	19454	50	GPM6A,ERBB4
7.928e-03	-4.84	APOA1 (apolipoprotein A1)	protein interactions	335	159	3	19454	50	CLU,GJA1,MACF1
7.928e-03	-4.84	TYRO3 (TYRO3 protein tyrosine kinase)	protein interactions	7301	159	3	19454	50	SLC1A3,APOE,CLU
7.938e-03	-4.84	urea channel activity	molecular function	GO:0015265	3	1	18094	48	SLC14A1
7.938e-03	-4.84	JUN kinase activity	molecular function	GO:0004705	3	1	18094	48	MAPK10
7.938e-03	-4.84	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular function	GO:0008454	3	1	18094	48	MGAT4C
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.938e-03	-4.84	neuregulin receptor activity	molecular function	GO:0038131	3	1	18094	48	ERBB4
7.938e-03	-4.84	epidermal growth factor receptor activity	molecular function	GO:0005006	3	1	18094	48	ERBB4
8.007e-03	-4.83	negative regulation of coagulation	biological process	GO:0050819	49	2	18204	50	PRKG1,APOE
8.007e-03	-4.83	oligodendrocyte development	biological process	GO:0014003	49	2	18204	50	CNTN1,CLU
8.012e-03	-4.83	skin-subungual-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-subungual-malignant_melanoma-acral_lentiginous	144	3	16828	48	MACF1,CDH20,LRP1B
8.030e-03	-4.82	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	30	16828	48	FMN2,ATP1A2,DTNA,TRPM3,ZBTB20,CNTN1,ADCY2,SORBS1,NKAIN3,PARD3,CTNND2,DCLK2,NTRK2,TRPS1,CST3,TNIK,PRKG1,NEBL,NPAS3,LRP1B,GLIS3,SOX5,TNC,MACF1,RORA,RYR3,NRG3,DGKG,ERBB4,SLC1A3
8.065e-03	-4.82	PTPN14 (protein tyrosine phosphatase non-receptor type 14)	protein interactions	5784	160	3	19454	50	PARD3,GJA1,CTNNA2
8.065e-03	-4.82	SOX5 (SRY-box transcription factor 5)	protein interactions	6660	160	3	19454	50	SOX5,TRPS1,NFIA
8.078e-03	-4.82	Connexin_C	interpro domains	IPR034634	3	1	18521	50	GJA1
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	DAG_kinase_typeI_N	interpro domains	IPR029477	3	1	18521	50	DGKG
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	TM_ErbB1	interpro domains	IPR049328	3	1	18521	50	ERBB4
8.078e-03	-4.82	DGK_typeI_N_sf	interpro domains	IPR038199	3	1	18521	50	DGKG
8.078e-03	-4.82	MAPK_JNK	interpro domains	IPR008351	3	1	18521	50	MAPK10
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	PARD3,MACF1,DTNA,SORBS1
8.100e-03	-4.82	ITCH (itchy E3 ubiquitin protein ligase)	protein interactions	83737	309	4	19454	50	RORA,GLIS3,GJA1,ERBB4
8.124e-03	-4.81	neuronal cell body	cellular component	GO:0043025	489	5	19108	49	GPM6A,APOE,SLC1A3,CTNND2,ATP1A2
8.178e-03	-4.81	Retinoid metabolism and transport	REACTOME pathways	R-HSA-975634	44	2	10285	32	GPC5,APOE
8.218e-03	-4.80	cell communication by chemical coupling	biological process	GO:0010643	3	1	18204	50	GJA1
8.218e-03	-4.80	very-low-density lipoprotein particle clearance	biological process	GO:0034447	3	1	18204	50	APOE
8.218e-03	-4.80	central nervous system morphogenesis	biological process	GO:0021551	3	1	18204	50	ERBB4
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.218e-03	-4.80	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	50	CLU
8.218e-03	-4.80	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	50	NEBL
8.218e-03	-4.80	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	50	FMN2
8.218e-03	-4.80	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	50	FMN2
8.218e-03	-4.80	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	50	FMN2
8.218e-03	-4.80	positive regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032805	3	1	18204	50	APOE
8.218e-03	-4.80	mammary placode formation	biological process	GO:0060596	3	1	18204	50	NRG3
8.218e-03	-4.80	bud outgrowth involved in lung branching	biological process	GO:0060447	3	1	18204	50	TNC
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.218e-03	-4.80	immune complex clearance	biological process	GO:0002434	3	1	18204	50	CLU
8.218e-03	-4.80	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	50	CTNNA2
8.218e-03	-4.80	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	50	NTRK2
8.220e-03	-4.80	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	4	16828	48	LRP1B,ERBB4,TNIK,ATP1A2
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR3
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK2
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR3
8.238e-03	-4.80	SR_plectin_7	pfam domains	PF21097	3	1	17795	49	MACF1
8.238e-03	-4.80	DAG_kinase_N	pfam domains	PF14513	3	1	17795	49	DGKG
8.238e-03	-4.80	Myelin_PLP	pfam domains	PF01275	3	1	17795	49	GPM6A
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR3
8.238e-03	-4.80	Sorb	pfam domains	PF02208	3	1	17795	49	SORBS1
8.238e-03	-4.80	TM_ErbB1	pfam domains	PF21314	3	1	17795	49	ERBB4
8.247e-03	-4.80	negative regulation of secretion by cell	biological process	GO:1903531	151	3	18204	50	GJA1,PRKG1,APOE
8.266e-03	-4.80	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	48	2	16828	48	PARD3,RYR3
8.295e-03	-4.79	endoplasmic reticulum lumen	cellular component	GO:0005788	312	4	19108	49	APOE,TNC,CLU,CST3
8.317e-03	-4.79	synaptic signaling	biological process	GO:0099536	459	5	18204	50	NTRK2,DTNA,APOE,SLC1A2,SLC1A3
8.327e-03	-4.79	vasodilation	biological process	GO:0042311	50	2	18204	50	PRKG1,APOE
8.355e-03	-4.78	positive regulation of macromolecule biosynthetic process	biological process	GO:0010557	2592	14	18204	50	CNTN1,NTRK2,RORA,ERBB4,NFIA,CLU,RFX4,SORBS1,GJA1,GLIS3,NPAS3,APOE,TNC,ZBTB20
8.397e-03	-4.78	blood vessel diameter maintenance	biological process	GO:0097746	152	3	18204	50	APOE,PRKG1,ATP1A2
8.397e-03	-4.78	regulation of tube diameter	biological process	GO:0035296	152	3	18204	50	ATP1A2,PRKG1,APOE
8.476e-03	-4.77	subungual	COSMIC cancer mutations	subungual	147	3	16828	48	MACF1,LRP1B,CDH20
8.476e-03	-4.77	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	3	18094	48	ATP1A2,SLC1A3,SLC1A2
8.478e-03	-4.77	EF-hand	gene3d domains	1.10.238.10	272	4	14470	43	DGKG,DTNA,MACF1,RYR3
8.507e-03	-4.77	SYNM (synemin)	protein interactions	23336	54	2	19454	50	DTNA,ERBB4
8.541e-03	-4.76	protein localization to membrane	biological process	GO:0072657	462	5	18204	50	TNIK,MACF1,ERBB4,PARD3,APOE
8.549e-03	-4.76	regulation of tube size	biological process	GO:0035150	153	3	18204	50	APOE,PRKG1,ATP1A2
8.554e-03	-4.76	SNCA (synuclein alpha)	protein interactions	6622	696	6	19454	50	APOE,MACF1,TNIK,NTRK2,CLU,GPM6A
8.627e-03	-4.75	LRBA (LPS responsive beige-like anchor protein)	protein interactions	987	164	3	19454	50	MACF1,GJA1,NTRK2
8.761e-03	-4.74	postsynaptic density	cellular component	GO:0014069	317	4	19108	49	TNIK,NTRK2,CTNND2,ERBB4
8.771e-03	-4.74	EGR2 (early growth response 2)	protein interactions	1959	165	3	19454	50	SOX5,NFIA,TRPS1
8.857e-03	-4.73	regeneration	biological process	GO:0031099	155	3	18204	50	TNC,ERBB4,GJA1
8.869e-03	-4.73	mannosyl-glycoprotein N-acetylglucosaminyltransferases	BIOCYC pathways	META_PWY-7426	8	1	902	1	MGAT4C
8.889e-03	-4.72	-	gene3d domains	1.10.490.160	3	1	14470	43	RYR3
8.889e-03	-4.72	Diacylglycerol kinase alpha	gene3d domains	1.10.238.110	3	1	14470	43	DGKG
8.889e-03	-4.72	-	gene3d domains	6.10.250.2510	3	1	14470	43	CTNNA2
8.985e-03	-4.71	positive regulation of biological process	biological process	GO:0048518	6326	26	18204	50	HPSE2,PARD3,GPC5,GLIS3,ATP1A2,SOX5,APOE,NPAS3,FMN2,SORBS1,RFX4,PRKG1,TNIK,CNTN1,RORA,TNC,ZBTB20,CLU,NFIA,SLC1A3,ERBB4,GJA1,SLC1A2,GPM6A,MACF1,NTRK2
9.013e-03	-4.71	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	50	NTRK2,NFIA,GPM6A
9.013e-03	-4.71	protein autophosphorylation	biological process	GO:0046777	156	3	18204	50	NTRK2,TNIK,ERBB4
9.125e-03	-4.70	CSTL1 (cystatin like 1)	protein interactions	128817	56	2	19454	50	CLU,APOE
9.125e-03	-4.70	SEPTIN3 (septin 3)	protein interactions	55964	56	2	19454	50	GPM6A,PRKG1
9.125e-03	-4.70	L1CAM (L1 cell adhesion molecule)	protein interactions	3897	56	2	19454	50	GPM6A,CNTN1
9.212e-03	-4.69	GAB1 (GRB2 associated binding protein 1)	protein interactions	2549	168	3	19454	50	PARD3,NTRK2,GJA1
9.253e-03	-4.68	mucosal	COSMIC cancer mutations	mucosal	2009	12	16828	48	LRP1B,SORBS1,PARD3,RORA,TNC,NRG3,CTNND2,ERBB4,MGAT4C,FMN2,ATP1A2,NEBL
9.253e-03	-4.68	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	12	16828	48	LRP1B,SORBS1,PARD3,TNC,RORA,NRG3,CTNND2,ERBB4,MGAT4C,FMN2,ATP1A2,NEBL
9.280e-03	-4.68	transferase activity, transferring phosphorus-containing groups	molecular function	GO:0016772	903	7	18094	48	NTRK2,DCLK2,TNIK,DGKG,MAPK10,ERBB4,PRKG1
9.306e-03	-4.68	Transport of connexins along the secretory pathway	REACTOME pathways	R-HSA-190827	3	1	10285	32	GJA1
9.306e-03	-4.68	Oligomerization of connexins into connexons	REACTOME pathways	R-HSA-190704	3	1	10285	32	GJA1
9.306e-03	-4.68	c-src mediated regulation of Cx43 function and closure of gap junctions	REACTOME pathways	R-HSA-191647	3	1	10285	32	GJA1
9.306e-03	-4.68	Regulation of gap junction activity	REACTOME pathways	R-HSA-191650	3	1	10285	32	GJA1
9.318e-03	-4.68	regulation of chondrocyte differentiation	biological process	GO:0032330	53	2	18204	50	TRPS1,SOX5
9.318e-03	-4.68	regulation of platelet activation	biological process	GO:0010543	53	2	18204	50	PRKG1,APOE
9.318e-03	-4.68	neutral amino acid transport	biological process	GO:0015804	53	2	18204	50	SLC1A2,SLC1A3
9.361e-03	-4.67	DLG5 (discs large MAGUK scaffold protein 5)	protein interactions	9231	169	3	19454	50	PARD3,NTRK2,GJA1
9.393e-03	-4.67	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	5	16828	48	ERBB4,PRKG1,NTRK2,DCLK2,TNIK
9.475e-03	-4.66	Ser/Thr_kinase_AS	interpro domains	IPR008271	308	4	18521	50	TNIK,PRKG1,MAPK10,DCLK2
9.561e-03	-4.65	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	5	16828	48	TNIK,DCLK2,NTRK2,PRKG1,ERBB4
9.564e-03	-4.65	side of membrane	cellular component	GO:0098552	715	6	19108	49	DTNA,GPC5,AQP4,NTM,LSAMP,CNTN1
9.634e-03	-4.64	LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)	protein interactions	55004	714	6	19454	50	SLC1A3,FMN2,TNIK,DTNA,PARD3,GJA1
9.659e-03	-4.64	regulation of alcohol biosynthetic process	biological process	GO:1902930	54	2	18204	50	APOE,PRKG1
9.663e-03	-4.64	response to abiotic stimulus	biological process	GO:0009628	1100	8	18204	50	RORA,SLC1A2,ATP1A2,FMN2,MAPK10,GJA1,TNC,SLC1A3
9.665e-03	-4.64	PPFIBP1 (PPFIA binding protein 1)	protein interactions	8496	171	3	19454	50	NTRK2,GJA1,PARD3
9.687e-03	-4.64	lipid transfer activity	molecular function	GO:0120013	56	2	18094	48	PITPNC1,APOE
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	ATP1A2,NTRK2,GPM6A
9.819e-03	-4.62	negative regulation of supramolecular fiber organization	biological process	GO:1902904	161	3	18204	50	APOE,CTNNA2,CLU
9.819e-03	-4.62	positive regulation of neuron projection development	biological process	GO:0010976	161	3	18204	50	APOE,NTRK2,CNTN1
9.883e-03	-4.62	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	6	16828	48	TNIK,PRKG1,ERBB4,DCLK2,NTRK2,TRPS1
9.975e-03	-4.61	LSR (lipolysis stimulated lipoprotein receptor)	protein interactions	51599	173	3	19454	50	PARD3,GJA1,NTRK2
1.001e-02	-4.60	response to cocaine	biological process	GO:0042220	55	2	18204	50	SLC1A3,SLC1A2
1.001e-02	-4.60	intermembrane lipid transfer	biological process	GO:0120009	55	2	18204	50	PITPNC1,APOE
1.002e-02	-4.60	Znf_NHR/GATA	interpro domains	IPR013088	56	2	18521	50	TRPS1,RORA
1.004e-02	-4.60	NCOR1 (nuclear receptor corepressor 1)	protein interactions	9611	329	4	19454	50	NFIA,SOX5,ERBB4,DGKG
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	NTRK2,ATP1A2,GPM6A
1.008e-02	-4.60	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	5	16828	48	NTRK2,DCLK2,TNIK,ERBB4,PRKG1
1.009e-02	-4.60	MARVELD2 (MARVEL domain containing 2)	protein interactions	153562	59	2	19454	50	GJA1,PARD3
1.012e-02	-4.59	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	5	12186	43	PRKG1,ERBB4,NTRK2,TNIK,DCLK2
1.018e-02	-4.59	positive regulation of cellular biosynthetic process	biological process	GO:0031328	2652	14	18204	50	CNTN1,NTRK2,RORA,ERBB4,CLU,NFIA,RFX4,GJA1,SORBS1,GLIS3,APOE,NPAS3,TNC,ZBTB20
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	CDH20,CTNNA2,DTNA
1.022e-02	-4.58	tenascin complex	cellular component	GO:0090733	4	1	19108	49	TNC
1.022e-02	-4.58	intermediate-density lipoprotein particle	cellular component	GO:0034363	4	1	19108	49	APOE
1.022e-02	-4.58	internode region of axon	cellular component	GO:0033269	4	1	19108	49	PARD3
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	IGKV@ (immunoglobulin kappa variable cluster)	protein interactions	3519	4	1	19454	50	LRP1B
1.027e-02	-4.58	IGc2	smart domains	SM00408	239	4	9717	35	CNTN1,NTRK2,NTM,LSAMP
1.029e-02	-4.58	LRP1 (LDL receptor related protein 1)	protein interactions	4035	175	3	19454	50	CLU,APOE,LRP1B
1.029e-02	-4.58	LHX3 (LIM homeobox 3)	protein interactions	8022	175	3	19454	50	SOX5,TRPS1,NFIA
1.034e-02	-4.57	positive regulation of cellular process	biological process	GO:0048522	5719	24	18204	50	TNC,ZBTB20,GPM6A,MACF1,SLC1A2,NTRK2,SLC1A3,ERBB4,CLU,NFIA,GJA1,GLIS3,APOE,NPAS3,SOX5,HPSE2,PARD3,GPC5,TNIK,CNTN1,RORA,RFX4,FMN2,SORBS1
1.034e-02	-4.57	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	7	19454	50	TNC,CTNND2,ZBTB20,ADCY2,SLC1A3,NFIA,TRPS1
1.036e-02	-4.57	cardiac muscle cell action potential	biological process	GO:0086001	56	2	18204	50	GJA1,ATP1A2
1.036e-02	-4.57	asymmetric synapse	cellular component	GO:0032279	333	4	19108	49	ERBB4,CTNND2,NTRK2,TNIK
1.043e-02	-4.56	actin cytoskeleton	cellular component	GO:0015629	520	5	19108	49	NEBL,MACF1,CTNNA2,FMN2,SORBS1
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	ATP1A2,SLC1A3,SLC1A2
1.050e-02	-4.56	response to light stimulus	biological process	GO:0009416	312	4	18204	50	SLC1A2,ATP1A2,SLC1A3,MAPK10
1.053e-02	-4.55	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	22	CST3,SLC1A2
1.055e-02	-4.55	SOHO	prosite domains	PS50831	3	1	12186	43	SORBS1
1.055e-02	-4.55	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	43	GPM6A
1.055e-02	-4.55	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	43	GPM6A
1.055e-02	-4.55	VINCULIN_1	prosite domains	PS00663	3	1	12186	43	CTNNA2
1.057e-02	-4.55	very-low-density lipoprotein particle receptor binding	molecular function	GO:0070326	4	1	18094	48	APOE
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.057e-02	-4.55	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	48	NTRK2
1.058e-02	-4.55	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	10	16828	48	ADCY2,LRP1B,PARD3,GPC5,TRPM3,RYR3,NRG3,ERBB4,PRKG1,HPSE2
1.059e-02	-4.55	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	48	16828	48	HPSE2,AQP4,NEBL,CST3,SLC14A1,SLC1A2,MGAT4C,SLC1A3,DGKG,CLU,SOX5,APOE,MSI2,RORA,GPM6A,NTM,GJA1,ATP1A2,FMN2,NFIA,CTNND2,RFX4,CNTN1,TNIK,PRKG1,NPAS3,DCLK2,NTRK2,TRPS1,ERBB4,NRG3,RYR3,TNC,MACF1,LRP1B,GLIS3,ZBTB20,PITPNC1,DTNA,TRPM3,GPC5,CDH20,LSAMP,SORBS1,NKAIN3,PARD3,ADCY2,NHSL1
1.071e-02	-4.54	sulfur compound transmembrane transporter activity	molecular function	GO:1901682	59	2	18094	48	GJA1,SLC1A2
1.072e-02	-4.54	visual behavior	biological process	GO:0007632	57	2	18204	50	ATP1A2,SLC1A2
1.072e-02	-4.54	establishment of spindle localization	biological process	GO:0051293	57	2	18204	50	GJA1,FMN2
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	Tyr_kinase_EGF/ERB/XmrK_rcpt	interpro domains	IPR016245	4	1	18521	50	ERBB4
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	Glyco_transf_54	interpro domains	IPR006759	4	1	18521	50	MGAT4C
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.076e-02	-4.53	ApoA_E	interpro domains	IPR000074	4	1	18521	50	APOE
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	PRKG1,TNIK
1.077e-02	-4.53	Sorb	smart domains	SM00459	3	1	9717	35	SORBS1
1.077e-02	-4.53	PLP	smart domains	SM00002	3	1	9717	35	GPM6A
1.077e-02	-4.53	KIDINS220 (kinase D interacting substrate 220)	protein interactions	57498	178	3	19454	50	PARD3,GJA1,NTRK2
1.080e-02	-4.53	ACTB (actin beta)	protein interactions	60	958	7	19454	50	FMN2,DTNA,MACF1,NHSL1,SORBS1,APOE,NEBL
1.082e-02	-4.53	regulation of cell motility	biological process	GO:2000145	1122	8	18204	50	APOE,MACF1,NRG3,PRKG1,CTNNA2,GJA1,TNC,ERBB4
1.084e-02	-4.52	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	47	16828	48	ZBTB20,DTNA,GPC5,TRPM3,PITPNC1,LSAMP,CDH20,PARD3,SORBS1,NKAIN3,ADCY2,NHSL1,PRKG1,NPAS3,TNIK,TRPS1,DCLK2,NTRK2,ERBB4,NRG3,RYR3,MACF1,TNC,GLIS3,LRP1B,GJA1,ATP1A2,FMN2,CTNND2,RFX4,NFIA,CNTN1,NEBL,AQP4,HPSE2,SLC14A1,SLC1A2,MGAT4C,DGKG,SLC1A3,CLU,MSI2,RORA,APOE,SOX5,GPM6A,NTM
1.085e-02	-4.52	adrenal_cortical_adenoma	COSMIC cancer mutations	adrenal_cortical_adenoma	161	3	16828	48	FMN2,LRP1B,ADCY2
1.087e-02	-4.52	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	2	10285	32	NRG3,ERBB4
1.087e-02	-4.52	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	32	SLC1A2,SLC1A3
1.094e-02	-4.52	MINK1 (misshapen like kinase 1)	protein interactions	50488	179	3	19454	50	TNIK,NTRK2,GJA1
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.094e-02	-4.52	NMDA glutamate receptor clustering	biological process	GO:0097114	4	1	18204	50	APOE
1.094e-02	-4.52	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	50	CLU
1.094e-02	-4.52	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	50	NTRK2
1.094e-02	-4.52	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	50	NTRK2
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	50	CST3
1.094e-02	-4.52	positive regulation of phospholipid efflux	biological process	GO:1902995	4	1	18204	50	APOE
1.094e-02	-4.52	cardiac muscle tissue regeneration	biological process	GO:0061026	4	1	18204	50	ERBB4
1.094e-02	-4.52	positive regulation of striated muscle tissue development	biological process	GO:0045844	4	1	18204	50	GJA1
1.094e-02	-4.52	negative regulation of protein kinase C signaling	biological process	GO:0090038	4	1	18204	50	DGKG
1.094e-02	-4.52	positive regulation of mesodermal cell differentiation	biological process	GO:1905772	4	1	18204	50	GJA1
1.094e-02	-4.52	response to caloric restriction	biological process	GO:0061771	4	1	18204	50	APOE
1.094e-02	-4.52	regulation of phospholipid efflux	biological process	GO:1902994	4	1	18204	50	APOE
1.094e-02	-4.52	positive regulation of muscle organ development	biological process	GO:0048636	4	1	18204	50	GJA1
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.097e-02	-4.51	Nebulin	pfam domains	PF00880	4	1	17795	49	NEBL
1.097e-02	-4.51	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	49	NFIA
1.097e-02	-4.51	CTF_NFI	pfam domains	PF00859	4	1	17795	49	NFIA
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	Glyco_transf_54	pfam domains	PF04666	4	1	17795	49	MGAT4C
1.097e-02	-4.51	Apolipoprotein	pfam domains	PF01442	4	1	17795	49	APOE
1.097e-02	-4.51	Spectrin_4	pfam domains	PF21020	4	1	17795	49	MACF1
1.097e-02	-4.51	Spectrin_3	pfam domains	PF21019	4	1	17795	49	MACF1
1.097e-02	-4.51	Spectrin_2	pfam domains	PF18373	4	1	17795	49	MACF1
1.097e-02	-4.51	TRPM_tetra	pfam domains	PF16519	4	1	17795	49	TRPM3
1.097e-02	-4.51	NHS	pfam domains	PF15273	4	1	17795	49	NHSL1
1.110e-02	-4.50	cellular homeostasis	biological process	GO:0019725	689	6	18204	50	AQP4,ZBTB20,APOE,RYR3,ATP1A2,SLC1A3
1.110e-02	-4.50	PTPN13 (protein tyrosine phosphatase non-receptor type 13)	protein interactions	5783	180	3	19454	50	PARD3,NTRK2,GJA1
1.110e-02	-4.50	MYOD1 (myogenic differentiation 1)	protein interactions	4654	180	3	19454	50	RORA,NFIA,TRPS1
1.110e-02	-4.50	EPHA4 (EPH receptor A4)	protein interactions	2043	180	3	19454	50	PARD3,GJA1,CTNNA2
1.114e-02	-4.50	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	6	16828	48	LRP1B,ERBB4,PRKG1,DCLK2,TNIK,NTRK2
1.120e-02	-4.49	modulation of chemical synaptic transmission	biological process	GO:0050804	494	5	18204	50	NTRK2,APOE,NRG3,ATP1A2,SLC1A3
1.129e-02	-4.48	Aquaporin-mediated transport	REACTOME pathways	R-HSA-445717	52	2	10285	32	ADCY2,AQP4
1.129e-02	-4.48	regulation of trans-synaptic signaling	biological process	GO:0099177	495	5	18204	50	NTRK2,APOE,NRG3,ATP1A2,SLC1A3
1.142e-02	-4.47	localization	biological process	GO:0051179	4474	20	18204	50	NTRK2,PITPNC1,SLC14A1,DCLK2,MACF1,TNIK,GPM6A,SLC1A2,RYR3,FMN2,GJA1,SLC1A3,ERBB4,CLU,AQP4,APOE,LRP1B,ATP1A2,TRPM3,PARD3
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.144e-02	-4.47	RYANODINER	prints domains	PR00795	3	1	5227	20	RYR3
1.144e-02	-4.47	NTKRECEPTOR	prints domains	PR01939	3	1	5227	20	NTRK2
1.144e-02	-4.47	RORNUCRECPTR	prints domains	PR01293	3	1	5227	20	RORA
1.144e-02	-4.47	MYELINPLP	prints domains	PR00214	3	1	5227	20	GPM6A
1.144e-02	-4.47	JNKMAPKINASE	prints domains	PR01772	3	1	5227	20	MAPK10
1.145e-02	-4.47	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	6	16828	48	LRP1B,NTRK2,TNIK,DCLK2,ERBB4,PRKG1
1.157e-02	-4.46	regulation of anatomical structure size	biological process	GO:0090066	498	5	18204	50	ATP1A2,MACF1,AQP4,PRKG1,APOE
1.161e-02	-4.46	MAPK9 (mitogen-activated protein kinase 9)	protein interactions	5601	183	3	19454	50	CLU,MAPK10,MACF1
1.163e-02	-4.45	back	COSMIC cancer mutations	back	310	4	16828	48	LRP1B,ERBB4,TNIK,ATP1A2
1.169e-02	-4.45	postsynaptic specialization	cellular component	GO:0099572	345	4	19108	49	TNIK,ERBB4,CTNND2,NTRK2
1.171e-02	-4.45	Metabolism of fat-soluble vitamins	REACTOME pathways	R-HSA-6806667	53	2	10285	32	APOE,GPC5
1.171e-02	-4.45	organic substance transport	biological process	GO:0071702	1881	11	18204	50	SLC14A1,NTRK2,PITPNC1,LRP1B,APOE,SLC1A2,MACF1,FMN2,GJA1,CLU,SLC1A3
1.174e-02	-4.44	negative regulation of secretion	biological process	GO:0051048	172	3	18204	50	PRKG1,APOE,GJA1
1.176e-02	-4.44	positive regulation of biosynthetic process	biological process	GO:0009891	2697	14	18204	50	CNTN1,NTRK2,RORA,ERBB4,NFIA,CLU,RFX4,SORBS1,GJA1,GLIS3,NPAS3,APOE,TNC,ZBTB20
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	ERBB4,NTRK2
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	TRPS1,NFIA
1.182e-02	-4.44	protein homotetramerization	biological process	GO:0051289	60	2	18204	50	AQP4,RYR3
1.182e-02	-4.44	regulation of smooth muscle contraction	biological process	GO:0006940	60	2	18204	50	ATP1A2,PRKG1
1.182e-02	-4.44	export across plasma membrane	biological process	GO:0140115	60	2	18204	50	ATP1A2,GJA1
1.182e-02	-4.44	regulation of glucose import	biological process	GO:0046324	60	2	18204	50	SORBS1,SLC1A2
1.182e-02	-4.44	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	50	ATP1A2,NTRK2
1.184e-02	-4.44	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	43	TRPM3
1.184e-02	-4.44	-	gene3d domains	1.20.58.1060	4	1	14470	43	MACF1
1.184e-02	-4.44	cadherin binding	molecular function	GO:0045296	335	4	18094	48	CTNND2,CTNNA2,MACF1,CDH20
1.192e-02	-4.43	chemical homeostasis	biological process	GO:0048878	914	7	18204	50	SLC1A3,ATP1A2,ZBTB20,APOE,AQP4,RORA,RYR3
1.192e-02	-4.43	regulation of cell size	biological process	GO:0008361	173	3	18204	50	AQP4,APOE,MACF1
1.192e-02	-4.43	regulation of smooth muscle cell proliferation	biological process	GO:0048660	173	3	18204	50	APOE,PRKG1,GJA1
1.200e-02	-4.42	Erythroid Transcription Factor GATA-1, subunit A	gene3d domains	3.30.50.10	56	2	14470	43	TRPS1,RORA
1.204e-02	-4.42	protein phosphorylation	biological process	GO:0006468	503	5	18204	50	TNIK,ERBB4,NTRK2,PRKG1,MAPK10
1.205e-02	-4.42	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	48	16828	48	MGAT4C,SLC1A2,NEBL,AQP4,HPSE2,SLC14A1,CST3,RORA,MSI2,APOE,SOX5,NTM,GPM6A,SLC1A3,DGKG,CLU,ATP1A2,FMN2,GJA1,CNTN1,RFX4,CTNND2,NFIA,TRPS1,NTRK2,DCLK2,NPAS3,PRKG1,TNIK,TNC,MACF1,GLIS3,LRP1B,ERBB4,RYR3,NRG3,ZBTB20,TRPM3,GPC5,DTNA,PITPNC1,PARD3,NKAIN3,SORBS1,NHSL1,ADCY2,LSAMP,CDH20
1.212e-02	-4.41	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	12	16828	48	NFIA,ERBB4,ADCY2,LRP1B,SOX5,DTNA,PRKG1,TNIK,TRPS1,NTRK2,ATP1A2,DCLK2
1.213e-02	-4.41	Heparan sulfate/heparin (HS-GAG) metabolism	REACTOME pathways	R-HSA-1638091	54	2	10285	32	GPC5,HPSE2
1.223e-02	-4.40	cellular response to organonitrogen compound	biological process	GO:0071417	505	5	18204	50	SLC1A3,SLC1A2,SORBS1,RYR3,GJA1
1.230e-02	-4.40	KLF5 (KLF transcription factor 5)	protein interactions	688	187	3	19454	50	CLU,TRPS1,NFIA
1.234e-02	-4.40	establishment of localization	biological process	GO:0051234	3887	18	18204	50	PARD3,TRPM3,ATP1A2,AQP4,LRP1B,APOE,ERBB4,SLC1A3,CLU,FMN2,RYR3,GJA1,MACF1,GPM6A,SLC1A2,NTRK2,PITPNC1,SLC14A1
1.234e-02	-4.39	salivary_gland-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma-adenoid_cystic_carcinoma	488	5	16828	48	PRKG1,RORA,CTNND2,MGAT4C,RYR3
1.248e-02	-4.38	HNF1B (HNF1 homeobox B)	protein interactions	6928	188	3	19454	50	TRPS1,NFIA,SOX5
1.249e-02	-4.38	central nervous system neuron differentiation	biological process	GO:0021953	176	3	18204	50	NTRK2,DCLK2,RORA
1.259e-02	-4.38	sulfur compound transport	biological process	GO:0072348	62	2	18204	50	GJA1,SLC1A2
1.259e-02	-4.38	spindle localization	biological process	GO:0051653	62	2	18204	50	GJA1,FMN2
1.269e-02	-4.37	carbohydrate derivative binding	molecular function	GO:0097367	2251	12	18094	48	ADCY2,PRKG1,ATP1A2,TNC,ERBB4,MAPK10,DGKG,TNIK,APOE,DCLK2,NTRK2,HPSE2
1.276e-02	-4.36	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	49	CLU
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	PPP1R17 (protein phosphatase 1 regulatory subunit 17)	protein interactions	10842	5	1	19454	50	PRKG1
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	NRG2 (neuregulin 2)	protein interactions	9542	5	1	19454	50	ERBB4
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.281e-02	-4.36	skin-upper_back-malignant_melanoma	COSMIC cancer mutations	skin-upper_back-malignant_melanoma	319	4	16828	48	ERBB4,MACF1,GPC5,CNTN1
1.287e-02	-4.35	SHC3 (SHC adaptor protein 3)	protein interactions	53358	67	2	19454	50	NTRK2,ERBB4
1.287e-02	-4.35	ARMC1 (armadillo repeat containing 1)	protein interactions	55156	67	2	19454	50	CNTN1,GPM6A
1.287e-02	-4.35	EFR3B (EFR3 homolog B)	protein interactions	22979	67	2	19454	50	GJA1,PARD3
1.298e-02	-4.34	regulation of nitric oxide biosynthetic process	biological process	GO:0045428	63	2	18204	50	APOE,CLU
1.301e-02	-4.34	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	2	10285	32	ATP1A2,RYR3
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	NEBL,SORBS1
1.306e-02	-4.34	lipid homeostasis	biological process	GO:0055088	179	3	18204	50	RORA,ZBTB20,APOE
1.310e-02	-4.34	central_nervous_system-cerebrum-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-cerebrum-glioma-astrocytoma_Grade_IV	61	2	16828	48	LRP1B,CNTN1
1.310e-02	-4.34	temporoparietal	COSMIC cancer mutations	temporoparietal	61	2	16828	48	PARD3,RYR3
1.318e-02	-4.33	main axon	cellular component	GO:0044304	68	2	19108	49	SLC1A2,PARD3
1.320e-02	-4.33	glutathione transmembrane transporter activity	molecular function	GO:0034634	5	1	18094	48	GJA1
1.320e-02	-4.33	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	48	NTRK2
1.320e-02	-4.33	gap junction channel activity involved in cardiac conduction electrical coupling	molecular function	GO:0086075	5	1	18094	48	GJA1
1.320e-02	-4.33	syndecan binding	molecular function	GO:0045545	5	1	18094	48	TNC
1.324e-02	-4.32	MARK1 (microtubule affinity regulating kinase 1)	protein interactions	4139	68	2	19454	50	GJA1,DTNA
1.324e-02	-4.32	circulatory system development	biological process	GO:0072359	933	7	18204	50	RORA,NTRK2,APOE,GJA1,PRKG1,NEBL,ERBB4
1.325e-02	-4.32	regulation of cellular component organization	biological process	GO:0051128	2455	13	18204	50	DGKG,CTNNA2,NRG3,GJA1,TNC,CLU,NTRK2,APOE,CNTN1,MACF1,CST3,TNIK,GPM6A
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A3,SLC1A2
1.328e-02	-4.32	env (Envelope surface glycoprotein gp160, precursor)	protein interactions	155971	1501	9	19454	50	CTNNA2,MGAT4C,MAPK10,NTRK2,TNC,CST3,APOE,ADCY2,SLC1A2
1.331e-02	-4.32	regulation of locomotion	biological process	GO:0040012	1164	8	18204	50	MACF1,APOE,TNC,ERBB4,GJA1,PRKG1,CTNNA2,NRG3
1.332e-02	-4.32	human chr4q21.3	chromosome location	human chr4q21.3	7	1	26134	50	MAPK10
1.335e-02	-4.32	camera-type eye development	biological process	GO:0043010	335	4	18204	50	NTRK2,GJA1,GPM6A,NFIA
1.336e-02	-4.32	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	4	16828	48	LRP1B,NTM,ADCY2,SORBS1
1.337e-02	-4.31	transport	biological process	GO:0006810	3615	17	18204	50	LRP1B,APOE,AQP4,ATP1A2,TRPM3,SLC14A1,PITPNC1,NTRK2,SLC1A2,GPM6A,MACF1,GJA1,RYR3,FMN2,CLU,SLC1A3,ERBB4
1.337e-02	-4.31	dendrite morphogenesis	biological process	GO:0048813	64	2	18204	50	CTNNA2,CTNND2
1.337e-02	-4.31	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	50	FMN2,SORBS1
1.341e-02	-4.31	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	26	16828	48	CTNND2,CDH20,PARD3,SORBS1,ADCY2,CNTN1,GJA1,ZBTB20,TRPM3,GPC5,FMN2,DGKG,ERBB4,RYR3,NRG3,TNC,MACF1,RORA,SOX5,LRP1B,AQP4,NEBL,NPAS3,TRPS1,NTRK2,MGAT4C
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	EGF_Tenascin	interpro domains	IPR041161	5	1	18521	50	TNC
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.346e-02	-4.31	cell-cell junction organization	biological process	GO:0045216	181	3	18204	50	PARD3,CDH20,GJA1
1.366e-02	-4.29	stem cell differentiation	biological process	GO:0048863	182	3	18204	50	MSI2,GPM6A,ERBB4
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	50	FMN2
1.366e-02	-4.29	cellular response to prostaglandin D stimulus	biological process	GO:0071799	5	1	18204	50	TNC
1.366e-02	-4.29	glutamate receptor clustering	biological process	GO:0097688	5	1	18204	50	APOE
1.366e-02	-4.29	response to prostaglandin D	biological process	GO:0071798	5	1	18204	50	TNC
1.366e-02	-4.29	positive regulation of dendritic spine maintenance	biological process	GO:1902952	5	1	18204	50	APOE
1.366e-02	-4.29	negative regulation of glutamate secretion	biological process	GO:0014050	5	1	18204	50	PRKG1
1.366e-02	-4.29	AMPA glutamate receptor clustering	biological process	GO:0097113	5	1	18204	50	APOE
1.366e-02	-4.29	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	50	NTRK2
1.366e-02	-4.29	chylomicron remnant clearance	biological process	GO:0034382	5	1	18204	50	APOE
1.366e-02	-4.29	ERBB2-ERBB4 signaling pathway	biological process	GO:0038135	5	1	18204	50	ERBB4
1.366e-02	-4.29	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	50	CLU
1.369e-02	-4.29	EGF_Tenascin	pfam domains	PF18720	5	1	17795	49	TNC
1.369e-02	-4.29	Vinculin	pfam domains	PF01044	5	1	17795	49	CTNNA2
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.377e-02	-4.29	apoptotic mitochondrial changes	biological process	GO:0008637	65	2	18204	50	CLU,ERBB4
1.377e-02	-4.29	tissue regeneration	biological process	GO:0042246	65	2	18204	50	ERBB4,GJA1
1.377e-02	-4.29	regulation of nitric oxide metabolic process	biological process	GO:0080164	65	2	18204	50	APOE,CLU
1.381e-02	-4.28	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	5	16828	48	DCLK2,TNIK,NTRK2,ERBB4,PRKG1
1.383e-02	-4.28	ATP binding	molecular function	GO:0005524	1467	9	18094	48	DGKG,TNIK,DCLK2,NTRK2,ADCY2,PRKG1,ATP1A2,MAPK10,ERBB4
1.386e-02	-4.28	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	38	16828	48	ZBTB20,TRPM3,GPC5,DTNA,ATP1A2,FMN2,RFX4,CTNND2,LSAMP,CDH20,PARD3,NKAIN3,SORBS1,NHSL1,ADCY2,CNTN1,NPAS3,AQP4,NEBL,PRKG1,HPSE2,TNIK,TRPS1,NTRK2,MGAT4C,SLC1A2,SLC1A3,DGKG,ERBB4,RYR3,NRG3,CLU,MACF1,RORA,TNC,SOX5,GPM6A,LRP1B
1.389e-02	-4.28	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	50	MACF1,CTNND2,APOE,GPC5
1.392e-02	-4.27	extracellular matrix	cellular component	GO:0031012	559	5	19108	49	TNC,APOE,GPC5,HPSE2,CLU
1.399e-02	-4.27	DUSP10 (dual specificity phosphatase 10)	protein interactions	11221	70	2	19454	50	MAPK10,ERBB4
1.399e-02	-4.27	PCDH20 (protocadherin 20)	protein interactions	64881	70	2	19454	50	CTNNA2,MGAT4C
1.399e-02	-4.27	MTMR9 (myotubularin related protein 9)	protein interactions	66036	70	2	19454	50	ERBB4,CLU
1.402e-02	-4.27	external encapsulating structure	cellular component	GO:0030312	560	5	19108	49	HPSE2,CLU,GPC5,APOE,TNC
1.404e-02	-4.27	CTF_NFI_1	prosite domains	PS00349	4	1	12186	43	NFIA
1.404e-02	-4.27	NEBULIN	prosite domains	PS51216	4	1	12186	43	NEBL
1.404e-02	-4.27	CTF_NFI_2	prosite domains	PS51080	4	1	12186	43	NFIA
1.406e-02	-4.26	upper_back	COSMIC cancer mutations	upper_back	328	4	16828	48	GPC5,CNTN1,ERBB4,MACF1
1.408e-02	-4.26	cell population proliferation	biological process	GO:0008283	726	6	18204	50	GJA1,RORA,SOX5,CLU,NFIA,HPSE2
1.412e-02	-4.26	YES1 (YES proto-oncogene 1, Src family tyrosine kinase)	protein interactions	7525	364	4	19454	50	ERBB4,GJA1,SLC14A1,MSI2
1.412e-02	-4.26	membrane protein complex	cellular component	GO:0098796	1261	8	19108	49	RYR3,SLC1A2,SORBS1,ATP1A2,GJA1,CDH20,SLC1A3,CTNNA2
1.412e-02	-4.26	neuron to neuron synapse	cellular component	GO:0098984	365	4	19108	49	TNIK,NTRK2,CTNND2,ERBB4
1.414e-02	-4.26	PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3)	protein interactions	8503	197	3	19454	50	NEBL,ERBB4,NTRK2
1.418e-02	-4.26	cardiac muscle cell development	biological process	GO:0055013	66	2	18204	50	PRKG1,NEBL
1.418e-02	-4.26	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	50	SLC1A2,SLC1A3
1.418e-02	-4.26	ERBB signaling pathway	biological process	GO:0038127	66	2	18204	50	NRG3,ERBB4
1.427e-02	-4.25	response to growth factor	biological process	GO:0070848	525	5	18204	50	ERBB4,TNC,NFIA,NTRK2,SOX5
1.433e-02	-4.25	NEBU	smart domains	SM00227	4	1	9717	35	NEBL
1.433e-02	-4.25	NFIX (nuclear factor I X)	protein interactions	4784	198	3	19454	50	TRPS1,NFIA,SOX5
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	PARD3,MACF1
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	TNIK,GPM6A
1.437e-02	-4.24	TSPAN17 (tetraspanin 17)	protein interactions	26262	71	2	19454	50	GPM6A,GJA1
1.447e-02	-4.24	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	5	16828	48	ERBB4,PRKG1,NTRK2,TNIK,DCLK2
1.450e-02	-4.23	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	4	16828	48	SORBS1,NTM,LRP1B,ADCY2
1.451e-02	-4.23	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	50	TNIK,PARD3,NTRK2,CLU
1.458e-02	-4.23	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	47	16828	48	PITPNC1,GPC5,TRPM3,ZBTB20,CDH20,LSAMP,ADCY2,NHSL1,SORBS1,NKAIN3,PARD3,TNIK,PRKG1,NPAS3,DCLK2,NTRK2,TRPS1,NRG3,RYR3,ERBB4,LRP1B,GLIS3,TNC,MACF1,GJA1,FMN2,ATP1A2,NFIA,CTNND2,RFX4,CNTN1,CST3,SLC14A1,HPSE2,AQP4,NEBL,SLC1A2,MGAT4C,CLU,DGKG,SLC1A3,GPM6A,NTM,SOX5,APOE,MSI2,RORA
1.459e-02	-4.23	cholesterol transport	biological process	GO:0030301	67	2	18204	50	APOE,CLU
1.468e-02	-4.22	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	10	18204	50	DCLK2,RORA,NTRK2,TNIK,ATP1A2,MAPK10,DGKG,PRKG1,ADCY2,ERBB4
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	14773	47	16828	48	TRPS1,DCLK2,NTRK2,PRKG1,NPAS3,TNIK,TNC,MACF1,GLIS3,LRP1B,ERBB4,RYR3,NRG3,ZBTB20,DTNA,TRPM3,GPC5,PITPNC1,PARD3,SORBS1,ADCY2,NHSL1,LSAMP,CDH20,SLC1A2,MGAT4C,NEBL,AQP4,HPSE2,SLC14A1,CST3,MSI2,RORA,APOE,SOX5,GPM6A,NTM,DGKG,SLC1A3,CLU,ATP1A2,FMN2,GJA1,CNTN1,CTNND2,RFX4,NFIA
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-desmoplastic	14773	47	16828	48	MSI2,RORA,APOE,SOX5,GPM6A,NTM,SLC1A3,DGKG,CLU,SLC1A2,MGAT4C,NEBL,AQP4,HPSE2,SLC14A1,CST3,CNTN1,CTNND2,RFX4,NFIA,ATP1A2,FMN2,GJA1,TNC,MACF1,GLIS3,LRP1B,ERBB4,RYR3,NRG3,TRPS1,DCLK2,NTRK2,PRKG1,NPAS3,TNIK,PARD3,SORBS1,ADCY2,NHSL1,LSAMP,CDH20,ZBTB20,DTNA,TRPM3,GPC5,PITPNC1
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma	14773	47	16828	48	GPM6A,NTM,APOE,SOX5,MSI2,RORA,CLU,DGKG,SLC1A3,SLC1A2,MGAT4C,CST3,SLC14A1,HPSE2,AQP4,NEBL,CNTN1,NFIA,CTNND2,RFX4,FMN2,ATP1A2,GJA1,LRP1B,GLIS3,MACF1,TNC,NRG3,RYR3,ERBB4,DCLK2,NTRK2,TRPS1,TNIK,PRKG1,NPAS3,ADCY2,NHSL1,SORBS1,PARD3,CDH20,LSAMP,PITPNC1,DTNA,TRPM3,GPC5,ZBTB20
1.470e-02	-4.22	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	COSMIC cancer mutations	central_nervous_system-medulla-primitive_neuroectodermal_tumour-medulloblastoma-classic	14773	47	16828	48	MACF1,TNC,GLIS3,LRP1B,ERBB4,RYR3,NRG3,TRPS1,NTRK2,DCLK2,NPAS3,PRKG1,TNIK,PARD3,SORBS1,NHSL1,ADCY2,LSAMP,CDH20,ZBTB20,TRPM3,GPC5,DTNA,PITPNC1,RORA,MSI2,SOX5,APOE,NTM,GPM6A,SLC1A3,DGKG,CLU,MGAT4C,SLC1A2,AQP4,NEBL,HPSE2,SLC14A1,CST3,CNTN1,RFX4,CTNND2,NFIA,ATP1A2,FMN2,GJA1
1.474e-02	-4.22	classic	COSMIC cancer mutations	classic	14774	47	16828	48	TRPS1,NTRK2,DCLK2,NPAS3,PRKG1,TNIK,MACF1,TNC,GLIS3,LRP1B,ERBB4,NRG3,RYR3,ZBTB20,GPC5,TRPM3,DTNA,PITPNC1,PARD3,SORBS1,NHSL1,ADCY2,LSAMP,CDH20,MGAT4C,SLC1A2,NEBL,AQP4,HPSE2,SLC14A1,CST3,RORA,MSI2,APOE,SOX5,NTM,GPM6A,SLC1A3,DGKG,CLU,ATP1A2,FMN2,GJA1,CNTN1,RFX4,CTNND2,NFIA
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	GPM6A,TNIK
1.477e-02	-4.22	Apolipoprotein	gene3d domains	1.20.120.20	5	1	14470	43	APOE
1.489e-02	-4.21	transcription cis-regulatory region binding	molecular function	GO:0000976	1485	9	18094	48	GLIS3,NFIA,RORA,RFX4,NPAS3,TRPS1,SOX5,ZBTB20,ERBB4
1.490e-02	-4.21	medulla	COSMIC cancer mutations	medulla	14778	47	16828	48	CLU,DGKG,SLC1A3,NTM,GPM6A,APOE,SOX5,RORA,MSI2,CST3,SLC14A1,HPSE2,AQP4,NEBL,MGAT4C,SLC1A2,NFIA,RFX4,CTNND2,CNTN1,GJA1,FMN2,ATP1A2,NRG3,RYR3,ERBB4,LRP1B,GLIS3,MACF1,TNC,TNIK,NPAS3,PRKG1,NTRK2,DCLK2,TRPS1,CDH20,LSAMP,NHSL1,ADCY2,SORBS1,PARD3,PITPNC1,GPC5,TRPM3,DTNA,ZBTB20
1.495e-02	-4.20	desmoplastic	COSMIC cancer mutations	desmoplastic	14779	47	16828	48	CST3,SLC14A1,HPSE2,AQP4,NEBL,MGAT4C,SLC1A2,CLU,DGKG,SLC1A3,NTM,GPM6A,SOX5,APOE,RORA,MSI2,GJA1,FMN2,ATP1A2,NFIA,RFX4,CTNND2,CNTN1,TNIK,NPAS3,PRKG1,NTRK2,DCLK2,TRPS1,RYR3,NRG3,ERBB4,LRP1B,GLIS3,MACF1,TNC,PITPNC1,GPC5,TRPM3,DTNA,ZBTB20,CDH20,LSAMP,NHSL1,ADCY2,SORBS1,PARD3
1.499e-02	-4.20	ARF6 (ADP ribosylation factor 6)	protein interactions	382	568	5	19454	50	GJA1,SLC1A3,TNIK,FMN2,PARD3
1.501e-02	-4.20	actin filament bundle organization	biological process	GO:0061572	68	2	18204	50	SORBS1,FMN2
1.501e-02	-4.20	transcription regulatory region nucleic acid binding	molecular function	GO:0001067	1487	9	18094	48	ZBTB20,ERBB4,SOX5,RORA,RFX4,NPAS3,TRPS1,GLIS3,NFIA
1.504e-02	-4.20	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	25	16828	48	NTRK2,DCLK2,NEBL,NPAS3,CST3,RORA,MACF1,TNC,SOX5,GLIS3,LRP1B,DGKG,SLC1A3,ERBB4,NRG3,RYR3,ATP1A2,ZBTB20,TRPM3,DTNA,PARD3,NKAIN3,ADCY2,CNTN1,CTNND2
1.511e-02	-4.19	Pkinase	pfam domains	PF00069	347	4	17795	49	PRKG1,MAPK10,DCLK2,TNIK
1.512e-02	-4.19	FEV (FEV transcription factor, ETS family member)	protein interactions	54738	202	3	19454	50	TRPS1,NFIA,SOX5
1.522e-02	-4.19	ALPHACATENIN	prints domains	PR00805	4	1	5227	20	CTNNA2
1.528e-02	-4.18	atypical	COSMIC cancer mutations	atypical	515	5	16828	48	NTRK2,TNIK,DCLK2,PRKG1,ERBB4
1.529e-02	-4.18	multivesicular body, internal vesicle	cellular component	GO:0097487	6	1	19108	49	APOE
1.529e-02	-4.18	PAR polarity complex	cellular component	GO:0120157	6	1	19108	49	PARD3
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	LCAT (lecithin-cholesterol acyltransferase)	protein interactions	3931	6	1	19454	50	APOE
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	SMOC2 (SPARC related modular calcium binding 2)	protein interactions	64094	6	1	19454	50	TNC
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	NRG4 (neuregulin 4)	protein interactions	145957	6	1	19454	50	ERBB4
1.532e-02	-4.18	Rara (retinoic acid receptor, alpha)	protein interactions	19401	6	1	19454	50	MAPK10
1.532e-02	-4.18	FXYD7 (FXYD domain containing ion transport regulator 7)	protein interactions	53822	6	1	19454	50	APOE
1.532e-02	-4.18	SAA4 (serum amyloid A4, constitutive)	protein interactions	6291	6	1	19454	50	GJA1
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.535e-02	-4.18	Immunoglobulin	interpro domains	IPR013151	70	2	18521	50	NTM,CNTN1
1.535e-02	-4.18	protein serine kinase activity	molecular function	GO:0106310	362	4	18094	48	TNIK,DCLK2,MAPK10,PRKG1
1.543e-02	-4.17	regulation of blood coagulation	biological process	GO:0030193	69	2	18204	50	PRKG1,APOE
1.546e-02	-4.17	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	32	NTRK2
1.547e-02	-4.17	cell-cell contact zone	cellular component	GO:0044291	74	2	19108	49	ATP1A2,GJA1
1.552e-02	-4.17	NFIC (nuclear factor I C)	protein interactions	4782	204	3	19454	50	SOX5,NFIA,TRPS1
1.554e-02	-4.16	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	2	19454	50	MSI2,ERBB4
1.554e-02	-4.16	CBARP (CACN subunit beta associated regulatory protein)	protein interactions	255057	74	2	19454	50	GJA1,NTRK2
1.561e-02	-4.16	monoatomic ion transport	biological process	GO:0006811	964	7	18204	50	GJA1,RYR3,TRPM3,SLC1A2,GPM6A,SLC1A3,ATP1A2
1.566e-02	-4.16	cerebrum	COSMIC cancer mutations	cerebrum	67	2	16828	48	CNTN1,LRP1B
1.572e-02	-4.15	UTRN (utrophin)	protein interactions	7402	205	3	19454	50	PARD3,DTNA,GJA1
1.581e-02	-4.15	phosphatidylcholine-sterol O-acyltransferase activator activity	molecular function	GO:0060228	6	1	18094	48	APOE
1.581e-02	-4.15	gap junction hemi-channel activity	molecular function	GO:0055077	6	1	18094	48	GJA1
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.584e-02	-4.15	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	47	16828	48	CNTN1,RFX4,CTNND2,NFIA,ATP1A2,FMN2,GJA1,RORA,SOX5,APOE,NTM,GPM6A,SLC1A3,DGKG,CLU,MGAT4C,SLC1A2,NEBL,AQP4,HPSE2,SLC14A1,CST3,PARD3,NKAIN3,SORBS1,NHSL1,ADCY2,LSAMP,CDH20,ZBTB20,TRPM3,GPC5,DTNA,PITPNC1,MACF1,TNC,GLIS3,LRP1B,ERBB4,RYR3,NRG3,TRPS1,NTRK2,DCLK2,NPAS3,PRKG1,TNIK
1.584e-02	-4.15	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	47	16828	48	CLU,SLC1A3,DGKG,GPM6A,NTM,SOX5,APOE,RORA,CST3,SLC14A1,HPSE2,NEBL,AQP4,SLC1A2,MGAT4C,NFIA,CTNND2,RFX4,CNTN1,GJA1,FMN2,ATP1A2,NRG3,RYR3,ERBB4,LRP1B,GLIS3,TNC,MACF1,TNIK,PRKG1,NPAS3,DCLK2,NTRK2,TRPS1,CDH20,LSAMP,ADCY2,NHSL1,SORBS1,NKAIN3,PARD3,PITPNC1,DTNA,TRPM3,GPC5,ZBTB20
1.585e-02	-4.14	cardiac conduction	biological process	GO:0061337	70	2	18204	50	GJA1,ATP1A2
1.585e-02	-4.14	negative regulation of smooth muscle cell proliferation	biological process	GO:0048662	70	2	18204	50	APOE,PRKG1
1.589e-02	-4.14	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	7	16828	48	TNIK,ERBB4,PRKG1,NTRK2,DCLK2,ATP1A2,MACF1
1.592e-02	-4.14	cellular process	biological process	GO:0009987	14996	47	18204	50	TNC,ZBTB20,SLC1A3,RYR3,GPM6A,NTRK2,PARD3,GPC5,GLIS3,LRP1B,MSI2,APOE,SOX5,CDH20,PRKG1,RFX4,FMN2,LSAMP,CNTN1,SLC14A1,DGKG,CTNNA2,AQP4,ERBB4,NFIA,NEBL,NHSL1,CLU,GJA1,MACF1,SLC1A2,HPSE2,TRPM3,ATP1A2,MGAT4C,ADCY2,NRG3,SORBS1,MAPK10,TNIK,CST3,NTM,DTNA,CTNND2,PITPNC1,DCLK2,RORA
1.592e-02	-4.14	ig	pfam domains	PF00047	70	2	17795	49	NTM,CNTN1
1.594e-02	-4.14	UNC5B (unc-5 netrin receptor B)	protein interactions	219699	75	2	19454	50	PARD3,GJA1
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	GF_recep_IV	interpro domains	IPR032778	6	1	18521	50	ERBB4
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY2
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.615e-02	-4.13	organelle organization	biological process	GO:0006996	3091	15	18204	50	DCLK2,MACF1,TNIK,FMN2,SORBS1,GJA1,RFX4,PRKG1,NEBL,NFIA,CLU,ERBB4,APOE,CTNNA2,PARD3
1.616e-02	-4.13	Regulation of lipolysis in adipocytes	KEGG pathways	hsa04923	54	2	7161	26	PRKG1,ADCY2
1.618e-02	-4.12	protein homooligomerization	biological process	GO:0051260	194	3	18204	50	RYR3,AQP4,SLC1A2
1.622e-02	-4.12	phosphorus metabolic process	biological process	GO:0006793	1707	10	18204	50	ERBB4,ADCY2,PRKG1,DGKG,MAPK10,TNIK,ATP1A2,NTRK2,RORA,DCLK2
1.628e-02	-4.12	regulation of hemostasis	biological process	GO:1900046	71	2	18204	50	PRKG1,APOE
1.629e-02	-4.12	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	50	MACF1,PRKG1,PARD3,CNTN1
1.633e-02	-4.11	RYK (receptor like tyrosine kinase)	protein interactions	6259	208	3	19454	50	CNTN1,CTNNA2,CLU
1.635e-02	-4.11	SHB (SH2 domain containing adaptor protein B)	protein interactions	6461	76	2	19454	50	ERBB4,GJA1
1.635e-02	-4.11	KIAA1549 (KIAA1549)	protein interactions	57670	76	2	19454	50	GJA1,PARD3
1.637e-02	-4.11	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	50	FMN2
1.637e-02	-4.11	triglyceride-rich lipoprotein particle clearance	biological process	GO:0071830	6	1	18204	50	APOE
1.637e-02	-4.11	regulation of low-density lipoprotein particle receptor catabolic process	biological process	GO:0032803	6	1	18204	50	APOE
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	intracellular water homeostasis	biological process	GO:0009992	6	1	18204	50	AQP4
1.637e-02	-4.11	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	50	CST3
1.637e-02	-4.11	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	50	SLC1A3
1.637e-02	-4.11	relaxation of vascular associated smooth muscle	biological process	GO:0060087	6	1	18204	50	PRKG1
1.637e-02	-4.11	mammary gland formation	biological process	GO:0060592	6	1	18204	50	NRG3
1.637e-02	-4.11	neuroblast migration	biological process	GO:0097402	6	1	18204	50	GJA1
1.637e-02	-4.11	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	50	CLU
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	RYR3
1.641e-02	-4.11	SH3_10	pfam domains	PF17902	6	1	17795	49	MACF1
1.641e-02	-4.11	GF_recep_IV	pfam domains	PF14843	6	1	17795	49	ERBB4
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	RYR3
1.641e-02	-4.11	EF-hand_2	pfam domains	PF09068	6	1	17795	49	DTNA
1.641e-02	-4.11	GAS2	pfam domains	PF02187	6	1	17795	49	MACF1
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	RYR3
1.641e-02	-4.11	Plectin	pfam domains	PF00681	6	1	17795	49	MACF1
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY2
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.641e-02	-4.11	EF-hand_3	pfam domains	PF09069	6	1	17795	49	DTNA
1.675e-02	-4.09	GOLGA4 (golgin A4)	protein interactions	2803	210	3	19454	50	TNIK,MACF1,GJA1
1.675e-02	-4.09	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	50	NHSL1,SORBS1,SLC1A3
1.676e-02	-4.09	actin cytoskeleton organization	biological process	GO:0030036	547	5	18204	50	NEBL,TNIK,SORBS1,FMN2,PRKG1
1.685e-02	-4.08	locomotory behavior	biological process	GO:0007626	197	3	18204	50	ATP1A2,CNTN1,APOE
1.692e-02	-4.08	breast-carcinoma-ductal_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductal_carcinoma	14824	47	16828	48	DTNA,TRPM3,GPC5,PITPNC1,ZBTB20,LSAMP,CDH20,ADCY2,PARD3,SORBS1,NKAIN3,PRKG1,NPAS3,TNIK,TRPS1,DCLK2,NTRK2,RYR3,NRG3,ERBB4,GLIS3,LRP1B,MACF1,TNC,GJA1,FMN2,ATP1A2,CTNND2,RFX4,NFIA,CNTN1,SLC14A1,CST3,AQP4,NEBL,HPSE2,SLC1A2,MGAT4C,CLU,SLC1A3,DGKG,GPM6A,NTM,MSI2,RORA,APOE,SOX5
1.696e-02	-4.08	CCDC88A (coiled-coil domain containing 88A)	protein interactions	55704	211	3	19454	50	PARD3,NTRK2,GJA1
1.700e-02	-4.07	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	48	NHSL1
1.700e-02	-4.07	localization within membrane	biological process	GO:0051668	549	5	18204	50	PARD3,MACF1,TNIK,ERBB4,APOE
1.711e-02	-4.07	regulation of protein catabolic process	biological process	GO:0042176	361	4	18204	50	CST3,CLU,APOE,FMN2
1.716e-02	-4.07	regulation of cartilage development	biological process	GO:0061035	73	2	18204	50	TRPS1,SOX5
1.716e-02	-4.07	cardiac cell development	biological process	GO:0055006	73	2	18204	50	PRKG1,NEBL
1.716e-02	-4.07	negative regulation of wound healing	biological process	GO:0061045	73	2	18204	50	APOE,PRKG1
1.717e-02	-4.06	APBB2 (amyloid beta precursor protein binding family B member 2)	protein interactions	323	78	2	19454	50	FMN2,GJA1
1.717e-02	-4.06	IFIT3 (interferon induced protein with tetratricopeptide repeats 3)	protein interactions	3437	78	2	19454	50	ATP1A2,APOE
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	SOX5,MSI2
1.717e-02	-4.06	LRP8 (LDL receptor related protein 8)	protein interactions	7804	78	2	19454	50	CLU,APOE
1.727e-02	-4.06	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	32	ERBB4,NRG3
1.731e-02	-4.06	cardiac muscle tissue development	biological process	GO:0048738	199	3	18204	50	NEBL,PRKG1,GJA1
1.731e-02	-4.06	positive regulation of ERK1 and ERK2 cascade	biological process	GO:0070374	199	3	18204	50	APOE,NTRK2,ERBB4
1.737e-02	-4.05	regulation of cellular process	biological process	GO:0050794	11468	39	18204	50	TRPS1,CNTN1,CST3,TNIK,RORA,DCLK2,PITPNC1,CTNND2,DTNA,ADCY2,MAPK10,FMN2,SORBS1,RFX4,PRKG1,NRG3,GLIS3,ATP1A2,SOX5,MSI2,APOE,NPAS3,PARD3,HPSE2,GPC5,SLC1A2,GPM6A,MACF1,NTRK2,CLU,NFIA,ERBB4,SLC1A3,GJA1,RYR3,TNC,ZBTB20,CTNNA2,DGKG
1.759e-02	-4.04	PRDM1 (PR/SET domain 1)	protein interactions	639	79	2	19454	50	NFIA,TRPS1
1.761e-02	-4.04	DLG1 (discs large MAGUK scaffold protein 1)	protein interactions	1739	214	3	19454	50	GJA1,ERBB4,PARD3
1.761e-02	-4.04	sterol transport	biological process	GO:0015918	74	2	18204	50	CLU,APOE
1.761e-02	-4.04	regulation of coagulation	biological process	GO:0050818	74	2	18204	50	APOE,PRKG1
1.765e-02	-4.04	animal organ morphogenesis	biological process	GO:0009887	988	7	18204	50	TNC,ERBB4,SOX5,GJA1,NTRK2,CTNNA2,NRG3
1.767e-02	-4.04	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	9	18094	48	ADCY2,PRKG1,ATP1A2,MAPK10,ERBB4,DGKG,TNIK,DCLK2,NTRK2
1.770e-02	-4.03	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	43	MACF1
1.770e-02	-4.03	Single helix bin	gene3d domains	1.20.5.490	6	1	14470	43	PRKG1
1.770e-02	-4.03	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	43	RYR3
1.770e-02	-4.03	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	43	MACF1
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.790e-02	-4.02	axonogenesis	biological process	GO:0007409	366	4	18204	50	PARD3,CNTN1,PRKG1,CTNNA2
1.793e-02	-4.02	large_cell	COSMIC cancer mutations	large_cell	14845	47	16828	48	SLC1A3,DGKG,CLU,APOE,SOX5,RORA,MSI2,NTM,GPM6A,HPSE2,AQP4,NEBL,CST3,SLC14A1,MGAT4C,SLC1A2,NFIA,RFX4,CTNND2,CNTN1,GJA1,ATP1A2,FMN2,ERBB4,RYR3,NRG3,TNC,MACF1,LRP1B,GLIS3,TNIK,NPAS3,PRKG1,NTRK2,DCLK2,TRPS1,CDH20,LSAMP,SORBS1,PARD3,NHSL1,ADCY2,ZBTB20,PITPNC1,GPC5,TRPM3,DTNA
1.794e-02	-4.02	cortisol_producing	COSMIC cancer mutations	cortisol_producing	72	2	16828	48	FMN2,LRP1B
1.794e-02	-4.02	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-cortisol_producing	72	2	16828	48	LRP1B,FMN2
1.801e-02	-4.02	MAP2 (microtubule associated protein 2)	protein interactions	4133	80	2	19454	50	GPM6A,APOE
1.804e-02	-4.01	ATP2B1 (ATPase plasma membrane Ca2+ transporting 1)	protein interactions	490	216	3	19454	50	NTRK2,GJA1,PARD3
1.806e-02	-4.01	body fluid secretion	biological process	GO:0007589	75	2	18204	50	GJA1,ERBB4
1.814e-02	-4.01	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	12	16828	48	TNIK,PRKG1,DTNA,DCLK2,ATP1A2,NTRK2,TRPS1,ERBB4,NFIA,SOX5,LRP1B,ADCY2
1.815e-02	-4.01	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	5	ADCY2
1.828e-02	-4.00	Signaling by PTK6	REACTOME pathways	R-HSA-8848021	67	2	10285	32	NRG3,ERBB4
1.836e-02	-4.00	plasma membrane protein complex	cellular component	GO:0098797	600	5	19108	49	CTNNA2,SORBS1,ATP1A2,GJA1,CDH20
1.840e-02	-4.00	actin filament binding	molecular function	GO:0051015	211	3	18094	48	MACF1,NEBL,CTNNA2
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	tripeptide transmembrane transporter activity	molecular function	GO:0042937	7	1	18094	48	GJA1
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.843e-02	-3.99	mitogen-activated protein kinase p38 binding	molecular function	GO:0048273	7	1	18094	48	PRKG1
1.843e-02	-3.99	FAM135A (family with sequence similarity 135 member A)	protein interactions	57579	81	2	19454	50	GJA1,NTRK2
1.843e-02	-3.99	SPRY4 (sprouty RTK signaling antagonist 4)	protein interactions	81848	81	2	19454	50	GJA1,NTRK2
1.843e-02	-3.99	SOX17 (SRY-box transcription factor 17)	protein interactions	64321	81	2	19454	50	NFIA,TRPS1
1.851e-02	-3.99	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	34	16828	48	FMN2,ATP1A2,GPC5,TRPM3,PITPNC1,ADCY2,NHSL1,CNTN1,SORBS1,NKAIN3,LSAMP,CTNND2,CDH20,NFIA,MGAT4C,TRPS1,DCLK2,NTRK2,PRKG1,NEBL,TNIK,HPSE2,GLIS3,LRP1B,MSI2,RORA,MACF1,TNC,APOE,SOX5,CLU,RYR3,ERBB4,DGKG
1.852e-02	-3.99	regulation of axon extension	biological process	GO:0030516	76	2	18204	50	MACF1,APOE
1.853e-02	-3.99	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	32	NTRK2
1.865e-02	-3.98	response to chemical	biological process	GO:0042221	3743	17	18204	50	ATP1A2,APOE,AQP4,TNC,ZBTB20,TNIK,SLC1A2,NTRK2,RORA,SLC1A3,CLU,ADCY2,NRG3,GJA1,FMN2,SORBS1,RYR3
1.872e-02	-3.98	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	50	TRPM3,RYR3,GPM6A
1.872e-02	-3.98	striated muscle tissue development	biological process	GO:0014706	205	3	18204	50	NEBL,PRKG1,GJA1
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Aquaporin_transptr	interpro domains	IPR034294	7	1	18521	50	AQP4
1.875e-02	-3.98	Furin-like_Cys-rich_dom	interpro domains	IPR006211	7	1	18521	50	ERBB4
1.875e-02	-3.98	Rcpt_L-dom_sf	interpro domains	IPR036941	7	1	18521	50	ERBB4
1.875e-02	-3.98	Ammonium/urea_transptr	interpro domains	IPR029020	7	1	18521	50	SLC14A1
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	Rcpt_L-dom	interpro domains	IPR000494	7	1	18521	50	ERBB4
1.891e-02	-3.97	system process	biological process	GO:0003008	2015	11	18204	50	SLC1A3,RYR3,GJA1,PRKG1,SLC1A2,NTRK2,DTNA,CTNNA2,ATP1A2,AQP4,APOE
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.898e-02	-3.96	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	50	NTRK2,MACF1
1.898e-02	-3.96	regulation of organic acid transport	biological process	GO:0032890	77	2	18204	50	PRKG1,ATP1A2
1.898e-02	-3.96	neural retina development	biological process	GO:0003407	77	2	18204	50	GPM6A,NTRK2
1.899e-02	-3.96	PITRANSFER	prints domains	PR00391	5	1	5227	20	PITPNC1
1.902e-02	-3.96	sequence-specific double-stranded DNA binding	molecular function	GO:1990837	1547	9	18094	48	ERBB4,ZBTB20,SOX5,TRPS1,RORA,RFX4,NPAS3,NFIA,GLIS3
1.907e-02	-3.96	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	50	CLU
1.907e-02	-3.96	very-low-density lipoprotein particle remodeling	biological process	GO:0034372	7	1	18204	50	APOE
1.907e-02	-3.96	high-density lipoprotein particle clearance	biological process	GO:0034384	7	1	18204	50	APOE
1.907e-02	-3.96	positive regulation of receptor catabolic process	biological process	GO:2000646	7	1	18204	50	APOE
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	50	NRG3
1.907e-02	-3.96	peripheral nervous system axon regeneration	biological process	GO:0014012	7	1	18204	50	TNC
1.907e-02	-3.96	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	50	FMN2
1.907e-02	-3.96	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	50	FMN2
1.907e-02	-3.96	glial cell fate specification	biological process	GO:0021780	7	1	18204	50	NFIA
1.907e-02	-3.96	glutathione transmembrane transport	biological process	GO:0034775	7	1	18204	50	GJA1
1.907e-02	-3.96	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	50	CTNNA2
1.907e-02	-3.96	relaxation of smooth muscle	biological process	GO:0044557	7	1	18204	50	PRKG1
1.907e-02	-3.96	regulation of testosterone biosynthetic process	biological process	GO:2000224	7	1	18204	50	PRKG1
1.909e-02	-3.96	solute:sodium symporter activity	molecular function	GO:0015370	80	2	18094	48	SLC1A3,SLC1A2
1.910e-02	-3.96	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	9	16828	48	MACF1,CNTN1,LRP1B,FMN2,NEBL,CDH20,RYR3,CTNND2,RFX4
1.910e-02	-3.96	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	9	16828	48	RFX4,CTNND2,RYR3,CDH20,NEBL,FMN2,LRP1B,CNTN1,MACF1
1.911e-02	-3.96	synaptic membrane	cellular component	GO:0097060	400	4	19108	49	ERBB4,SLC1A2,GPM6A,CNTN1
1.912e-02	-3.96	Recep_L_domain	pfam domains	PF01030	7	1	17795	49	ERBB4
1.912e-02	-3.96	Furin-like	pfam domains	PF00757	7	1	17795	49	ERBB4
1.917e-02	-3.95	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	22	SLC1A3,ATP1A2
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	ATP1A2,SORBS1
1.930e-02	-3.95	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	50	NFIA,TRPS1
1.930e-02	-3.95	ARHGEF10 (Rho guanine nucleotide exchange factor 10)	protein interactions	9639	83	2	19454	50	NTRK2,GJA1
1.939e-02	-3.94	PSEN1 (presenilin 1)	protein interactions	5663	222	3	19454	50	APOE,DTNA,CTNND2
1.939e-02	-3.94	PKP2 (plakophilin 2)	protein interactions	5318	222	3	19454	50	PARD3,NTRK2,GJA1
1.944e-02	-3.94	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	50	SORBS1,SLC1A2
1.944e-02	-3.94	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	2	18204	50	ZBTB20,SORBS1
1.954e-02	-3.94	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	48	NTRK2,ERBB4
1.962e-02	-3.93	UBE2A (ubiquitin conjugating enzyme E2 A)	protein interactions	7319	223	3	19454	50	GJA1,CTNNA2,TNIK
1.974e-02	-3.93	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	15	18204	50	RORA,NTRK2,TNIK,CNTN1,SORBS1,GJA1,RFX4,NFIA,CLU,ERBB4,NPAS3,APOE,GLIS3,ZBTB20,TNC
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	ERBB4,NTRK2
1.980e-02	-3.92	regulation of system process	biological process	GO:0044057	571	5	18204	50	ATP1A2,PARD3,APOE,PRKG1,GJA1
1.991e-02	-3.92	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	5	19454	50	NHSL1,CLU,PARD3,DTNA,TNIK
2.002e-02	-3.91	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	7	19454	50	SORBS1,NHSL1,MACF1,FMN2,PITPNC1,DCLK2,PARD3
2.008e-02	-3.91	KLF3 (KLF transcription factor 3)	protein interactions	51274	225	3	19454	50	SOX5,NFIA,TRPS1
2.018e-02	-3.90	CFAP298 (cilia and flagella associated protein 298)	protein interactions	56683	85	2	19454	50	FMN2,TRPS1
2.032e-02	-3.90	PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2)	protein interactions	5296	226	3	19454	50	NTRK2,ERBB4,GJA1
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.034e-02	-3.90	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	49	CLU
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	DEFB104A (defensin beta 104A)	protein interactions	140596	8	1	19454	50	GJA1
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.042e-02	-3.89	RAC3 (Rac family small GTPase 3)	protein interactions	5881	615	5	19454	50	FMN2,MACF1,GPM6A,PARD3,GJA1
2.042e-02	-3.89	negative regulation of cell migration	biological process	GO:0030336	381	4	18204	50	GJA1,NRG3,APOE,PRKG1
2.042e-02	-3.89	eye development	biological process	GO:0001654	381	4	18204	50	NTRK2,GJA1,GPM6A,NFIA
2.051e-02	-3.89	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	3	7161	26	ADCY2,PRKG1,ATP1A2
2.051e-02	-3.89	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	3	7161	26	ATP1A2,ADCY2,PRKG1
2.053e-02	-3.89	contractile actin filament bundle	cellular component	GO:0097517	86	2	19108	49	NEBL,SORBS1
2.053e-02	-3.89	stress fiber	cellular component	GO:0001725	86	2	19108	49	SORBS1,NEBL
2.055e-02	-3.88	MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)	protein interactions	9448	227	3	19454	50	PARD3,TNIK,GJA1
2.059e-02	-3.88	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	22	NRG3,ERBB4
2.062e-02	-3.88	Receptor L-domain	gene3d domains	3.80.20.20	7	1	14470	43	ERBB4
2.062e-02	-3.88	Ammonium transporter AmtB like domains	gene3d domains	1.10.3430.10	7	1	14470	43	SLC14A1
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	GPM6A,SORBS1
2.063e-02	-3.88	ATP7A (ATPase copper transporting alpha)	protein interactions	538	86	2	19454	50	GJA1,CLU
2.073e-02	-3.88	NOTCH2 (notch receptor 2)	protein interactions	4853	409	4	19454	50	PARD3,CNTN1,GJA1,NTRK2
2.092e-02	-3.87	positive regulation of macromolecule metabolic process	biological process	GO:0010604	3485	16	18204	50	APOE,NPAS3,GLIS3,ZBTB20,TNC,NTRK2,RORA,CNTN1,TNIK,RFX4,GJA1,SORBS1,FMN2,ERBB4,CLU,NFIA
2.099e-02	-3.86	GLYPICAN	prosite domains	PS01207	6	1	12186	43	GPC5
2.099e-02	-3.86	GAR	prosite domains	PS51460	6	1	12186	43	MACF1
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	MACF1,RYR3,DGKG
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	gap junction channel activity involved in cell communication by electrical coupling	molecular function	GO:1903763	8	1	18094	48	GJA1
2.103e-02	-3.86	cyclic nucleotide-dependent protein kinase activity	molecular function	GO:0004690	8	1	18094	48	PRKG1
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.103e-02	-3.86	urea transmembrane transporter activity	molecular function	GO:0015204	8	1	18094	48	SLC14A1
2.103e-02	-3.86	cellular response to nitrogen compound	biological process	GO:1901699	580	5	18204	50	GJA1,SORBS1,RYR3,SLC1A2,SLC1A3
2.108e-02	-3.86	KIAA0319L (KIAA0319 like)	protein interactions	79932	87	2	19454	50	MGAT4C,GJA1
2.108e-02	-3.86	NHLH1 (nescient helix-loop-helix 1)	protein interactions	4807	87	2	19454	50	TRPS1,NFIA
2.108e-02	-3.86	Kctd5 (potassium channel tetramerisation domain containing 5)	protein interactions	69259	87	2	19454	50	TRPS1,SLC1A3
2.108e-02	-3.86	ZNF608 (zinc finger protein 608)	protein interactions	57507	87	2	19454	50	SOX5,NFIA
2.111e-02	-3.86	anion binding	molecular function	GO:0043168	2412	12	18094	48	ADCY2,ERBB4,TNIK,SLC1A3,PARD3,PITPNC1,MAPK10,PRKG1,ATP1A2,DGKG,NTRK2,DCLK2
2.113e-02	-3.86	visual system development	biological process	GO:0150063	385	4	18204	50	NTRK2,GJA1,GPM6A,NFIA
2.130e-02	-3.85	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	5	16828	48	LRP1B,RYR3,ERBB4,TNIK,NTRK2
2.135e-02	-3.85	regulation of steroid biosynthetic process	biological process	GO:0050810	82	2	18204	50	APOE,PRKG1
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY2
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY2
2.142e-02	-3.84	GAS2	smart domains	SM00243	6	1	9717	35	MACF1
2.153e-02	-3.84	FGA (fibrinogen alpha chain)	protein interactions	2243	88	2	19454	50	LRP1B,GJA1
2.153e-02	-3.84	BTN2A2 (butyrophilin subfamily 2 member A2)	protein interactions	10385	88	2	19454	50	SLC14A1,SLC1A3
2.153e-02	-3.84	TMEM128 (transmembrane protein 128)	protein interactions	85013	88	2	19454	50	GJA1,SLC1A3
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	CNTN1,NTM,NTRK2,LSAMP
2.157e-02	-3.84	FYN (FYN proto-oncogene, Src family tyrosine kinase)	protein interactions	2534	414	4	19454	50	CNTN1,CTNND2,NTRK2,ERBB4
2.158e-02	-3.84	Neurofascin interactions	REACTOME pathways	R-HSA-447043	7	1	10285	32	CNTN1
2.159e-02	-3.84	SRC (SRC proto-oncogene, non-receptor tyrosine kinase)	protein interactions	6714	624	5	19454	50	SLC14A1,MSI2,ERBB4,SORBS1,GJA1
2.175e-02	-3.83	CTSB (cathepsin B)	protein interactions	1508	232	3	19454	50	MSI2,CST3,APOE
2.175e-02	-3.83	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	5	ADCY2
2.175e-02	-3.83	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	5	ADCY2
2.177e-02	-3.83	positive regulation of amyloid-beta clearance	biological process	GO:1900223	8	1	18204	50	APOE
2.177e-02	-3.83	gap junction assembly	biological process	GO:0016264	8	1	18204	50	GJA1
2.177e-02	-3.83	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	50	RORA
2.177e-02	-3.83	central nervous system myelin formation	biological process	GO:0032289	8	1	18204	50	CNTN1
2.177e-02	-3.83	triglyceride-rich lipoprotein particle remodeling	biological process	GO:0034370	8	1	18204	50	APOE
2.177e-02	-3.83	regulation of Cdc42 protein signal transduction	biological process	GO:0032489	8	1	18204	50	APOE
2.177e-02	-3.83	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	50	RORA
2.177e-02	-3.83	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	50	RORA
2.177e-02	-3.83	negative regulation of gonadotropin secretion	biological process	GO:0032277	8	1	18204	50	GJA1
2.177e-02	-3.83	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	50	SLC1A3
2.177e-02	-3.83	positive regulation of CoA-transferase activity	biological process	GO:1905920	8	1	18204	50	APOE
2.177e-02	-3.83	negative regulation of trophoblast cell migration	biological process	GO:1901164	8	1	18204	50	GJA1
2.177e-02	-3.83	regulation of ventricular cardiac muscle cell membrane depolarization	biological process	GO:0060373	8	1	18204	50	GJA1
2.177e-02	-3.83	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	50	FMN2
2.177e-02	-3.83	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	50	CTNNA2
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY2
2.182e-02	-3.82	LSDAT_euk	pfam domains	PF18139	8	1	17795	49	TRPM3
2.182e-02	-3.82	DCX	pfam domains	PF03607	8	1	17795	49	DCLK2
2.184e-02	-3.82	regulation of amine transport	biological process	GO:0051952	83	2	18204	50	ATP1A2,PRKG1
2.184e-02	-3.82	cardiac muscle contraction	biological process	GO:0060048	83	2	18204	50	ATP1A2,GJA1
2.196e-02	-3.82	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	3	16828	48	LRP1B,NTM,PRKG1
2.199e-02	-3.82	SOX10 (SRY-box transcription factor 10)	protein interactions	6663	89	2	19454	50	NFIA,TRPS1
2.203e-02	-3.82	SH3_domain	interpro domains	IPR001452	222	3	18521	50	NEBL,SORBS1,MACF1
2.221e-02	-3.81	sensory system development	biological process	GO:0048880	391	4	18204	50	NFIA,GPM6A,GJA1,NTRK2
2.224e-02	-3.81	HMG20A (high mobility group 20A)	protein interactions	10363	234	3	19454	50	SOX5,NFIA,DTNA
2.233e-02	-3.80	stem cell development	biological process	GO:0048864	84	2	18204	50	MSI2,ERBB4
2.233e-02	-3.80	peripheral nervous system development	biological process	GO:0007422	84	2	18204	50	PARD3,NTRK2
2.233e-02	-3.80	L-amino acid transport	biological process	GO:0015807	84	2	18204	50	SLC1A3,SLC1A2
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	DTNA,FMN2
2.250e-02	-3.79	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	50	ATP1A2,TNC,SLC1A3
2.260e-02	-3.79	synovial	COSMIC cancer mutations	synovial	8	1	16828	48	CNTN1
2.260e-02	-3.79	bone-knee-chondrosarcoma-synovial	COSMIC cancer mutations	bone-knee-chondrosarcoma-synovial	8	1	16828	48	CNTN1
2.279e-02	-3.78	PROTEIN_KINASE_ST	prosite domains	PS00108	308	4	12186	43	TNIK,MAPK10,DCLK2,PRKG1
2.285e-02	-3.78	astrocyte end-foot	cellular component	GO:0097450	9	1	19108	49	AQP4
2.285e-02	-3.78	fascia adherens	cellular component	GO:0005916	9	1	19108	49	GJA1
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.290e-02	-3.78	LINC02582 (long intergenic non-protein coding RNA 2582)	protein interactions	100505817	9	1	19454	50	APOE
2.290e-02	-3.78	MUC4 (mucin 4, cell surface associated)	protein interactions	4585	9	1	19454	50	ERBB4
2.290e-02	-3.78	CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3)	protein interactions	55799	9	1	19454	50	APOE
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.292e-02	-3.78	FOXI1 (forkhead box I1)	protein interactions	2299	91	2	19454	50	NFIA,TRPS1
2.292e-02	-3.78	PTPN21 (protein tyrosine phosphatase non-receptor type 21)	protein interactions	11099	91	2	19454	50	NRG3,ERBB4
2.292e-02	-3.78	TRIO (trio Rho guanine nucleotide exchange factor)	protein interactions	7204	91	2	19454	50	GJA1,PARD3
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	SORBS1,TNIK
2.308e-02	-3.77	LAMP1 (lysosomal associated membrane protein 1)	protein interactions	3916	635	5	19454	50	SLC1A3,FMN2,TNIK,MACF1,GJA1
2.315e-02	-3.77	negative regulation of cell motility	biological process	GO:2000146	396	4	18204	50	NRG3,PRKG1,APOE,GJA1
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	CLU,LRP1B,MACF1
2.326e-02	-3.76	EGF_1	prosite domains	PS00022	174	3	12186	43	LRP1B,NRG3,TNC
2.329e-02	-3.76	actomyosin	cellular component	GO:0042641	92	2	19108	49	NEBL,SORBS1
2.334e-02	-3.76	central nervous system neuron development	biological process	GO:0021954	86	2	18204	50	NTRK2,DCLK2
2.336e-02	-3.76	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	22	ADCY2,RYR3,GJA1
2.339e-02	-3.76	SOX9 (SRY-box transcription factor 9)	protein interactions	6662	92	2	19454	50	TRPS1,NFIA
2.339e-02	-3.76	ADGRG5 (adhesion G protein-coupled receptor G5)	protein interactions	221188	92	2	19454	50	GJA1,GPM6A
2.339e-02	-3.76	EPN2 (epsin 2)	protein interactions	22905	92	2	19454	50	APOE,GJA1
2.381e-02	-3.74	collagen-containing extracellular matrix	cellular component	GO:0062023	428	4	19108	49	CLU,GPC5,APOE,TNC
2.385e-02	-3.74	intermediate filament cytoskeleton	cellular component	GO:0045111	241	3	19108	49	GJA1,DTNA,MACF1
2.387e-02	-3.74	PTPRG (protein tyrosine phosphatase receptor type G)	protein interactions	5793	93	2	19454	50	GJA1,PARD3
2.387e-02	-3.74	parotid	COSMIC cancer mutations	parotid	578	5	16828	48	RYR3,LRP1B,ERBB4,NTRK2,TNIK
2.391e-02	-3.73	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	3	16828	48	DTNA,RFX4,MGAT4C
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	Doublecortin_dom	interpro domains	IPR003533	9	1	18521	50	DCLK2
2.404e-02	-3.73	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	50	CST3
2.408e-02	-3.73	ion binding	molecular function	GO:0043167	6007	23	18094	48	GLIS3,LRP1B,DTNA,SLC1A2,MAPK10,SLC1A3,TNIK,APOE,TRPS1,ADCY2,ZBTB20,MGAT4C,ERBB4,DGKG,NTRK2,DCLK2,PITPNC1,ATP1A2,PRKG1,PARD3,RYR3,RORA,MACF1
2.426e-02	-3.72	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	45	16828	48	SLC1A2,MGAT4C,SLC14A1,HPSE2,NEBL,AQP4,GPM6A,SOX5,APOE,MSI2,RORA,CLU,DGKG,SLC1A3,FMN2,ATP1A2,GJA1,CNTN1,NFIA,CTNND2,DCLK2,NTRK2,TRPS1,TNIK,PRKG1,NPAS3,LRP1B,GLIS3,TNC,MACF1,RYR3,NRG3,ERBB4,PITPNC1,DTNA,TRPM3,GPC5,ZBTB20,ADCY2,NHSL1,SORBS1,NKAIN3,PARD3,CDH20,LSAMP
2.426e-02	-3.72	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	45	16828	48	FMN2,ATP1A2,PITPNC1,GPC5,TRPM3,DTNA,ZBTB20,GJA1,CNTN1,NHSL1,ADCY2,NKAIN3,SORBS1,PARD3,NFIA,CDH20,CTNND2,LSAMP,MGAT4C,SLC1A2,NTRK2,DCLK2,TRPS1,SLC14A1,HPSE2,TNIK,NPAS3,AQP4,NEBL,PRKG1,LRP1B,GPM6A,GLIS3,APOE,SOX5,MACF1,RORA,TNC,MSI2,RYR3,NRG3,CLU,DGKG,ERBB4,SLC1A3
2.430e-02	-3.72	protein binding	molecular function	GO:0005515	13983	43	18094	48	PITPNC1,NTM,NRG3,CDH20,CLU,DCLK2,GPM6A,RORA,RYR3,PARD3,CST3,LSAMP,MAPK10,LRP1B,GLIS3,CTNNA2,ERBB4,TNC,SLC1A3,RFX4,ATP1A2,PRKG1,SORBS1,NTRK2,GPC5,AQP4,MSI2,MACF1,SOX5,CTNND2,HPSE2,SLC1A2,FMN2,NEBL,DTNA,NPAS3,ADCY2,CNTN1,GJA1,TNIK,NFIA,APOE,TRPS1
2.435e-02	-3.72	QSER1 (glutamine and serine rich 1)	protein interactions	79832	94	2	19454	50	NFIA,SOX5
2.435e-02	-3.72	KIAA1217 (KIAA1217)	protein interactions	56243	94	2	19454	50	PARD3,GJA1
2.435e-02	-3.72	FOXP4 (forkhead box P4)	protein interactions	116113	94	2	19454	50	SOX5,NFIA
2.435e-02	-3.72	TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1)	protein interactions	85461	94	2	19454	50	PARD3,GJA1
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CLU,CTNND2
2.436e-02	-3.71	regulation of tissue remodeling	biological process	GO:0034103	88	2	18204	50	GJA1,CST3
2.446e-02	-3.71	cholesterol catabolic process	biological process	GO:0006707	9	1	18204	50	APOE
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.446e-02	-3.71	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	50	CTNNA2
2.446e-02	-3.71	glutathione transport	biological process	GO:0034635	9	1	18204	50	GJA1
2.446e-02	-3.71	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	50	CTNNA2
2.446e-02	-3.71	tripeptide transmembrane transport	biological process	GO:0035443	9	1	18204	50	GJA1
2.446e-02	-3.71	macrophage proliferation	biological process	GO:0061517	9	1	18204	50	CLU
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.446e-02	-3.71	mesenchymal-epithelial cell signaling	biological process	GO:0060638	9	1	18204	50	TNC
2.446e-02	-3.71	sterol catabolic process	biological process	GO:0016127	9	1	18204	50	APOE
2.446e-02	-3.71	microglial cell proliferation	biological process	GO:0061518	9	1	18204	50	CLU
2.449e-02	-3.71	lower_third	COSMIC cancer mutations	lower_third	7961	30	16828	48	MACF1,RORA,TNC,SOX5,LRP1B,ERBB4,DGKG,NRG3,RYR3,TRPS1,NTRK2,DCLK2,MGAT4C,AQP4,NEBL,NPAS3,PRKG1,HPSE2,PARD3,SORBS1,ADCY2,CNTN1,CTNND2,CDH20,ATP1A2,FMN2,GJA1,ZBTB20,TRPM3,GPC5
2.452e-02	-3.71	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	49	RFX4
2.463e-02	-3.70	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	32	GPC5
2.463e-02	-3.70	Downregulation of ERBB4 signaling	REACTOME pathways	R-HSA-1253288	8	1	10285	32	ERBB4
2.470e-02	-3.70	EGF-like_dom	interpro domains	IPR000742	232	3	18521	50	NRG3,TNC,LRP1B
2.479e-02	-3.70	DDX31 (DEAD-box helicase 31)	protein interactions	64794	244	3	19454	50	PRKG1,CST3,CLU
2.489e-02	-3.69	adenyl nucleotide binding	molecular function	GO:0030554	1620	9	18094	48	ADCY2,ATP1A2,PRKG1,ERBB4,MAPK10,DGKG,TNIK,NTRK2,DCLK2
2.495e-02	-3.69	PLEC	smart domains	SM00250	7	1	9717	35	MACF1
2.496e-02	-3.69	DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	GO:0000981	1355	8	18094	48	RFX4,RORA,NPAS3,TRPS1,GLIS3,NFIA,ZBTB20,SOX5
2.500e-02	-3.69	Muscle contraction	REACTOME pathways	R-HSA-397014	204	3	10285	32	SORBS1,RYR3,ATP1A2
2.521e-02	-3.68	actin filament bundle	cellular component	GO:0032432	96	2	19108	49	SORBS1,NEBL
2.529e-02	-3.68	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	19	19454	50	MSI2,ATP1A2,GPM6A,CTNND2,CLU,SLC1A3,DTNA,MACF1,TNIK,LSAMP,APOE,TNC,PARD3,DCLK2,CTNNA2,PITPNC1,CNTN1,NTM,CST3
2.532e-02	-3.68	SOCS2 (suppressor of cytokine signaling 2)	protein interactions	8835	96	2	19454	50	ERBB4,NTRK2
2.534e-02	-3.68	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	5	ADCY2
2.534e-02	-3.68	g-Secretase Mediated ErbB4 Signalling Pathway	SMPDB pathways	SMP0089975	7	1	1369	5	ERBB4
2.541e-02	-3.67	PTPRT (protein tyrosine phosphatase receptor type T)	protein interactions	11122	10	1	19454	50	ERBB4
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	ZNF563 (zinc finger protein 563)	protein interactions	147837	10	1	19454	50	LRP1B
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	CHRDL1 (chordin like 1)	protein interactions	91851	10	1	19454	50	LRP1B
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	EREG (epiregulin)	protein interactions	2069	10	1	19454	50	ERBB4
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.546e-02	-3.67	regulation of biological process	biological process	GO:0050789	12079	40	18204	50	TRPS1,TNIK,CNTN1,CST3,PITPNC1,DTNA,CTNND2,DCLK2,RORA,ADCY2,PRKG1,RFX4,NRG3,MAPK10,SORBS1,FMN2,ATP1A2,GLIS3,MSI2,APOE,NPAS3,SOX5,HPSE2,PARD3,GPC5,NKAIN3,GPM6A,MACF1,SLC1A2,NTRK2,ERBB4,SLC1A3,CLU,NFIA,GJA1,RYR3,TNC,ZBTB20,CTNNA2,DGKG
2.547e-02	-3.67	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	7	19454	50	MACF1,APOE,NHSL1,SORBS1,PARD3,PITPNC1,GJA1
2.551e-02	-3.67	lipid binding	molecular function	GO:0008289	861	6	18094	48	RORA,APOE,PARD3,DGKG,ATP1A2,PITPNC1
2.579e-02	-3.66	biological regulation	biological process	GO:0065007	12501	41	18204	50	RYR3,GJA1,NFIA,CLU,ERBB4,SLC1A3,NTRK2,SLC1A2,MACF1,GPM6A,DGKG,CTNNA2,ZBTB20,TNC,AQP4,SORBS1,FMN2,MAPK10,PRKG1,RFX4,NRG3,ADCY2,DCLK2,RORA,CTNND2,DTNA,PITPNC1,CST3,TNIK,CNTN1,TRPS1,NKAIN3,GPC5,PARD3,HPSE2,SOX5,NPAS3,APOE,MSI2,GLIS3,ATP1A2
2.581e-02	-3.66	PLCB3 (phospholipase C beta 3)	protein interactions	5331	97	2	19454	50	PARD3,PRKG1
2.581e-02	-3.66	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	2	19454	50	DCLK2,CLU
2.585e-02	-3.66	ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)	protein interactions	25	248	3	19454	50	CTNND2,SORBS1,ERBB4
2.595e-02	-3.65	contractile muscle fiber	cellular component	GO:0043292	249	3	19108	49	GJA1,NEBL,RYR3
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.622e-02	-3.64	neurotrophin binding	molecular function	GO:0043121	10	1	18094	48	NTRK2
2.625e-02	-3.64	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	3	16828	48	MGAT4C,RFX4,DTNA
2.625e-02	-3.64	cell surface	cellular component	GO:0009986	896	6	19108	49	AQP4,SLC1A2,GPC5,ATP1A2,CLU,SLC1A3
2.629e-02	-3.64	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	3	5310	22	ADCY2,RYR3,GJA1
2.631e-02	-3.64	FRAS1 (Fraser extracellular matrix complex subunit 1)	protein interactions	80144	98	2	19454	50	HPSE2,MGAT4C
2.631e-02	-3.64	MB21D2 (Mab-21 domain containing 2)	protein interactions	151963	98	2	19454	50	NTRK2,GJA1
2.644e-02	-3.63	Doublecortin domain	gene3d domains	3.10.20.230	9	1	14470	43	DCLK2
2.646e-02	-3.63	human chr9q33.1	chromosome location	human chr9q33.1	14	1	26134	50	TNC
2.647e-02	-3.63	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	5	16828	48	LRP1B,CTNND2,TRPS1,MACF1,GJA1
2.649e-02	-3.63	negative regulation of locomotion	biological process	GO:0040013	413	4	18204	50	PRKG1,APOE,NRG3,GJA1
2.651e-02	-3.63	protein serine/threonine kinase activity	molecular function	GO:0004674	428	4	18094	48	PRKG1,MAPK10,DCLK2,TNIK
2.661e-02	-3.63	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	32	ATP1A2,RYR3,TRPM3
2.668e-02	-3.62	Diacylglycerol_kin_accessory	interpro domains	IPR000756	10	1	18521	50	DGKG
2.668e-02	-3.62	Doublecortin_dom_sf	interpro domains	IPR036572	10	1	18521	50	DCLK2
2.668e-02	-3.62	MIP_CS	interpro domains	IPR022357	10	1	18521	50	AQP4
2.668e-02	-3.62	DGK	interpro domains	IPR037607	10	1	18521	50	DGKG
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.676e-02	-3.62	inorganic cation transmembrane transport	biological process	GO:0098662	618	5	18204	50	RYR3,TRPM3,ATP1A2,SLC1A3,GPM6A
2.680e-02	-3.62	TPP1 (tripeptidyl peptidase 1)	protein interactions	1200	99	2	19454	50	APOE,DGKG
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	TRPS1,SOX5
2.690e-02	-3.62	chemical synaptic transmission	biological process	GO:0007268	415	4	18204	50	DTNA,APOE,SLC1A3,SLC1A2
2.690e-02	-3.62	anterograde trans-synaptic signaling	biological process	GO:0098916	415	4	18204	50	SLC1A2,SLC1A3,DTNA,APOE
2.693e-02	-3.61	CRX (cone-rod homeobox)	protein interactions	1406	252	3	19454	50	NFIA,TRPS1,SOX5
2.695e-02	-3.61	Calcium signaling pathway	KEGG pathways	ko04020	181	3	7161	26	ERBB4,RYR3,ADCY2
2.695e-02	-3.61	Calcium signaling pathway	KEGG pathways	hsa04020	181	3	7161	26	RYR3,ADCY2,ERBB4
2.698e-02	-3.61	double-stranded DNA binding	molecular function	GO:0003690	1643	9	18094	48	RFX4,RORA,NPAS3,TRPS1,GLIS3,NFIA,ZBTB20,ERBB4,SOX5
2.699e-02	-3.61	regulation of vascular associated smooth muscle cell proliferation	biological process	GO:1904705	93	2	18204	50	GJA1,PRKG1
2.699e-02	-3.61	regulation of extent of cell growth	biological process	GO:0061387	93	2	18204	50	APOE,MACF1
2.714e-02	-3.61	establishment of centrosome localization	biological process	GO:0051660	10	1	18204	50	PARD3
2.714e-02	-3.61	nitric oxide-cGMP-mediated signaling	biological process	GO:0038060	10	1	18204	50	APOE
2.714e-02	-3.61	regulation of CoA-transferase activity	biological process	GO:1905918	10	1	18204	50	APOE
2.714e-02	-3.61	regulation of behavioral fear response	biological process	GO:2000822	10	1	18204	50	APOE
2.714e-02	-3.61	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	50	ADCY2
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	50	NRG3
2.714e-02	-3.61	regulation of atrial cardiac muscle cell membrane depolarization	biological process	GO:0060371	10	1	18204	50	GJA1
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	negative regulation of sterol biosynthetic process	biological process	GO:0106119	10	1	18204	50	APOE
2.714e-02	-3.61	high-density lipoprotein particle assembly	biological process	GO:0034380	10	1	18204	50	APOE
2.714e-02	-3.61	regulation of mesodermal cell differentiation	biological process	GO:1905770	10	1	18204	50	GJA1
2.714e-02	-3.61	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	50	NTRK2
2.714e-02	-3.61	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	50	NTRK2
2.714e-02	-3.61	mitochondrial fragmentation involved in apoptotic process	biological process	GO:0043653	10	1	18204	50	ERBB4
2.714e-02	-3.61	retinal rod cell development	biological process	GO:0046548	10	1	18204	50	NTRK2
2.714e-02	-3.61	negative regulation of cholesterol biosynthetic process	biological process	GO:0045541	10	1	18204	50	APOE
2.714e-02	-3.61	urea transmembrane transport	biological process	GO:0071918	10	1	18204	50	SLC14A1
2.714e-02	-3.61	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	50	NRG3
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	NTRK2,ERBB4
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	RYR3
2.720e-02	-3.60	DAGK_acc	pfam domains	PF00609	10	1	17795	49	DGKG
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	GPM6A,ATP1A2
2.731e-02	-3.60	EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2)	protein interactions	55741	100	2	19454	50	HPSE2,CLU
2.753e-02	-3.59	blood circulation	biological process	GO:0008015	418	4	18204	50	ATP1A2,GJA1,PRKG1,APOE
2.756e-02	-3.59	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	50	MACF1,TNIK,ERBB4
2.767e-02	-3.59	Formation of annular gap junctions	REACTOME pathways	R-HSA-196025	9	1	10285	32	GJA1
2.767e-02	-3.59	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	32	CLU
2.773e-02	-3.59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	hsa05412	72	2	7161	26	CTNNA2,GJA1
2.773e-02	-3.59	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	ko05412	72	2	7161	26	CTNNA2,GJA1
2.776e-02	-3.58	DYNLL2 (dynein light chain LC8-type 2)	protein interactions	140735	255	3	19454	50	NFIA,TRPS1,NHSL1
2.777e-02	-3.58	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-aldosterone_producing	91	2	16828	48	ADCY2,LRP1B
2.781e-02	-3.58	CPNE8 (copine 8)	protein interactions	144402	101	2	19454	50	PARD3,GJA1
2.781e-02	-3.58	PRKCG (protein kinase C gamma)	protein interactions	5582	101	2	19454	50	PARD3,GJA1
2.781e-02	-3.58	FAM171A2 (family with sequence similarity 171 member A2)	protein interactions	284069	101	2	19454	50	NTRK2,GJA1
2.784e-02	-3.58	sequence-specific DNA binding	molecular function	GO:0043565	1652	9	18094	48	SOX5,ZBTB20,ERBB4,GLIS3,NFIA,NPAS3,RORA,RFX4,TRPS1
2.786e-02	-3.58	interstitial matrix	cellular component	GO:0005614	11	1	19108	49	TNC
2.786e-02	-3.58	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	49	TNC
2.789e-02	-3.58	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	43	TRPS1
2.792e-02	-3.58	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	1	19454	50	ADCY2
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	PRKG1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	SCN3A (sodium voltage-gated channel alpha subunit 3)	protein interactions	6328	11	1	19454	50	CNTN1
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.802e-02	-3.58	RNA polymerase II transcription regulatory region sequence-specific DNA binding	molecular function	GO:0000977	1385	8	18094	48	SOX5,ZBTB20,NFIA,GLIS3,TRPS1,RFX4,RORA,NPAS3
2.807e-02	-3.57	cardiac muscle cell differentiation	biological process	GO:0055007	95	2	18204	50	PRKG1,NEBL
2.809e-02	-3.57	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	50	SORBS1,NTRK2,NRG3,NFIA,ERBB4
2.814e-02	-3.57	basolateral plasma membrane	cellular component	GO:0016323	257	3	19108	49	AQP4,ERBB4,SLC14A1
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	human chr18q12.3	chromosome location	human chr18q12.3	15	1	26134	50	SLC14A1
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.836e-02	-3.56	SH3 Domains	gene3d domains	2.30.30.40	223	3	14470	43	MACF1,SORBS1,NEBL
2.838e-02	-3.56	response to radiation	biological process	GO:0009314	422	4	18204	50	ATP1A2,SLC1A3,SLC1A2,MAPK10
2.862e-02	-3.55	negative regulation of response to wounding	biological process	GO:1903035	96	2	18204	50	APOE,PRKG1
2.876e-02	-3.55	metal ion transport	biological process	GO:0030001	630	5	18204	50	RYR3,TRPM3,SLC1A3,GPM6A,ATP1A2
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.880e-02	-3.55	oligopeptide transmembrane transporter activity	molecular function	GO:0035673	11	1	18094	48	GJA1
2.880e-02	-3.55	ATP-dependent diacylglycerol kinase activity	molecular function	GO:0004143	11	1	18094	48	DGKG
2.881e-02	-3.55	gland development	biological process	GO:0048732	424	4	18204	50	NRG3,GJA1,TNC,ERBB4
2.884e-02	-3.55	PLEKHA1 (pleckstrin homology domain containing A1)	protein interactions	59338	103	2	19454	50	PARD3,GJA1
2.884e-02	-3.55	ZFYVE9 (zinc finger FYVE-type containing 9)	protein interactions	9372	103	2	19454	50	GJA1,NTRK2
2.889e-02	-3.54	MARK2 (microtubule affinity regulating kinase 2)	protein interactions	2011	259	3	19454	50	GJA1,DTNA,PARD3
2.891e-02	-3.54	aldosterone_producing	COSMIC cancer mutations	aldosterone_producing	93	2	16828	48	ADCY2,LRP1B
2.892e-02	-3.54	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	5	ADCY2
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A3,SLC1A2
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	CNTN1,NTM,LSAMP,NTRK2
2.907e-02	-3.54	viral process	biological process	GO:0016032	243	3	18204	50	NFIA,MGAT4C,APOE
2.917e-02	-3.53	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	50	SLC1A3,SLC1A2
2.917e-02	-3.53	acylglycerol metabolic process	biological process	GO:0006639	97	2	18204	50	APOE,DGKG
2.918e-02	-3.53	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	2	7161	26	ADCY2,ATP1A2
2.918e-02	-3.53	Thyroid hormone synthesis	KEGG pathways	ko04918	74	2	7161	26	ATP1A2,ADCY2
2.928e-02	-3.53	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	18	16828	48	RFX4,CTNND2,NRG3,CDH20,ERBB4,LRP1B,CNTN1,PARD3,MACF1,RORA,TNC,GPC5,NEBL,MGAT4C,FMN2,SLC1A2,TRPS1,ATP1A2
2.929e-02	-3.53	EF-hand_7	pfam domains	PF13499	97	2	17795	49	DGKG,MACF1
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.931e-02	-3.53	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	3	10285	32	SLC1A3,ADCY2,SLC1A2
2.935e-02	-3.53	Laminin	gene3d domains	2.10.25.10	226	3	14470	43	NRG3,LRP1B,TNC
2.935e-02	-3.53	tat (Tat)	protein interactions	155871	1718	9	19454	50	TNC,SLC14A1,PRKG1,GJA1,SLC1A2,ADCY2,RYR3,SORBS1,APOE
2.936e-02	-3.53	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	2	19454	50	CLU,SORBS1
2.940e-02	-3.53	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	2	12186	43	GLIS3,APOE
2.968e-02	-3.52	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	4	18204	50	RYR3,APOE,ATP1A2,SLC1A3
2.968e-02	-3.52	negative regulation of response to external stimulus	biological process	GO:0032102	428	4	18204	50	APOE,CTNNA2,PRKG1,RORA
2.968e-02	-3.52	cell surface receptor protein tyrosine kinase signaling pathway	biological process	GO:0007169	428	4	18204	50	ERBB4,SORBS1,NTRK2,NRG3
2.972e-02	-3.52	neutral lipid metabolic process	biological process	GO:0006638	98	2	18204	50	APOE,DGKG
2.975e-02	-3.52	amide binding	molecular function	GO:0033218	254	3	18094	48	CLU,CST3,APOE
2.977e-02	-3.51	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	32	ERBB4,NRG3
2.980e-02	-3.51	monoatomic cation transmembrane transport	biological process	GO:0098655	636	5	18204	50	ATP1A2,SLC1A3,GPM6A,RYR3,TRPM3
2.981e-02	-3.51	negative regulation of cholesterol metabolic process	biological process	GO:0090206	11	1	18204	50	APOE
2.981e-02	-3.51	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	50	NRG3
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	lipid phosphorylation	biological process	GO:0046834	11	1	18204	50	DGKG
2.981e-02	-3.51	physiological muscle hypertrophy	biological process	GO:0003298	11	1	18204	50	PRKG1
2.981e-02	-3.51	physiological cardiac muscle hypertrophy	biological process	GO:0003301	11	1	18204	50	PRKG1
2.981e-02	-3.51	pyramidal neuron development	biological process	GO:0021860	11	1	18204	50	DCLK2
2.981e-02	-3.51	tripeptide transport	biological process	GO:0042939	11	1	18204	50	GJA1
2.981e-02	-3.51	regulation of fear response	biological process	GO:1903365	11	1	18204	50	APOE
2.981e-02	-3.51	regulation of receptor catabolic process	biological process	GO:2000644	11	1	18204	50	APOE
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.981e-02	-3.51	ectodermal placode formation	biological process	GO:0060788	11	1	18204	50	NRG3
2.981e-02	-3.51	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	50	NRG3
2.981e-02	-3.51	cell growth involved in cardiac muscle cell development	biological process	GO:0061049	11	1	18204	50	PRKG1
2.981e-02	-3.51	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	50	PRKG1
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.988e-02	-3.51	IRF2BP2 (interferon regulatory factor 2 binding protein 2)	protein interactions	359948	105	2	19454	50	NFIA,ERBB4
2.988e-02	-3.51	BEND3 (BEN domain containing 3)	protein interactions	57673	105	2	19454	50	TRPS1,TNIK
2.991e-02	-3.51	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	26	ADCY2,ATP1A2
2.991e-02	-3.51	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	26	ATP1A2,ADCY2
3.022e-02	-3.50	GATAZNFINGER	prints domains	PR00619	8	1	5227	20	TRPS1
3.028e-02	-3.50	heart contraction	biological process	GO:0060047	99	2	18204	50	GJA1,ATP1A2
3.028e-02	-3.50	phospholipid transport	biological process	GO:0015914	99	2	18204	50	PITPNC1,APOE
3.035e-02	-3.49	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	49	TNC
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.036e-02	-3.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	5	19454	50	GJA1,SLC1A3,MACF1,FMN2,TNIK
3.040e-02	-3.49	PHACTR4 (phosphatase and actin regulator 4)	protein interactions	65979	106	2	19454	50	PARD3,GJA1
3.042e-02	-3.49	KIF26A (kinesin family member 26A)	protein interactions	26153	12	1	19454	50	MAPK10
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	PROK2 (prokineticin 2)	protein interactions	60675	12	1	19454	50	LRP1B
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	OAS2 (2'-5'-oligoadenylate synthetase 2)	protein interactions	4939	12	1	19454	50	PRKG1
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	SMIM20 (small integral membrane protein 20)	protein interactions	389203	12	1	19454	50	ERBB4
3.042e-02	-3.49	Pard6b (par-6 family cell polarity regulator beta)	protein interactions	58220	12	1	19454	50	PARD3
3.042e-02	-3.49	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	50	ERBB4
3.069e-02	-3.48	Activation of the AP-1 family of transcription factors	REACTOME pathways	R-HSA-450341	10	1	10285	32	MAPK10
3.069e-02	-3.48	Gap junction degradation	REACTOME pathways	R-HSA-190873	10	1	10285	32	GJA1
3.069e-02	-3.48	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	32	ADCY2
3.074e-02	-3.48	regulation of transport	biological process	GO:0051049	1621	9	18204	50	CLU,PRKG1,SORBS1,NKAIN3,GJA1,CNTN1,ATP1A2,SLC1A2,APOE
3.079e-02	-3.48	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	50	ATP1A2,SLC1A3,APOE,RYR3
3.085e-02	-3.48	regulation of dendrite development	biological process	GO:0050773	100	2	18204	50	DGKG,TNIK
3.089e-02	-3.48	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	4	10285	32	ADCY2,NTRK2,ERBB4,NRG3
3.093e-02	-3.48	EFR3A (EFR3 homolog A)	protein interactions	23167	107	2	19454	50	PARD3,GJA1
3.093e-02	-3.48	HTR3A (5-hydroxytryptamine receptor 3A)	protein interactions	3359	107	2	19454	50	GJA1,GPM6A
3.093e-02	-3.48	EPHA3 (EPH receptor A3)	protein interactions	2042	107	2	19454	50	PARD3,GJA1
3.095e-02	-3.48	peptide binding	molecular function	GO:0042277	258	3	18094	48	APOE,CST3,CLU
3.107e-02	-3.47	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	4	19454	50	TNIK,CNTN1,GJA1,CTNNA2
3.124e-02	-3.47	blood vessel morphogenesis	biological process	GO:0048514	435	4	18204	50	GJA1,RORA,APOE,NTRK2
3.132e-02	-3.46	DC	prosite domains	PS50309	9	1	12186	43	DCLK2
3.132e-02	-3.46	CYSTATIN	prosite domains	PS00287	9	1	12186	43	CST3
3.132e-02	-3.46	RFX_DBD	prosite domains	PS51526	9	1	12186	43	RFX4
3.138e-02	-3.46	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	48	ADCY2
3.142e-02	-3.46	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	50	RORA,SORBS1
3.142e-02	-3.46	cholesterol homeostasis	biological process	GO:0042632	101	2	18204	50	RORA,APOE
3.142e-02	-3.46	regulation of carbohydrate biosynthetic process	biological process	GO:0043255	101	2	18204	50	SORBS1,PRKG1
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	GPM6A,CLU
3.147e-02	-3.46	PAX8 (paired box 8)	protein interactions	7849	108	2	19454	50	TRPS1,NFIA
3.147e-02	-3.46	CLASP1 (cytoplasmic linker associated protein 1)	protein interactions	23332	108	2	19454	50	MACF1,DCLK2
3.147e-02	-3.46	EN1 (engrailed homeobox 1)	protein interactions	2019	108	2	19454	50	TRPS1,NFIA
3.147e-02	-3.46	SLC39A14 (solute carrier family 39 member 14)	protein interactions	23516	108	2	19454	50	PARD3,GJA1
3.151e-02	-3.46	VCL (vinculin)	protein interactions	7414	268	3	19454	50	MACF1,NEBL,SORBS1
3.157e-02	-3.46	calcium ion transport	biological process	GO:0006816	251	3	18204	50	RYR3,TRPM3,GPM6A
3.158e-02	-3.46	EGF_3	prosite domains	PS50026	196	3	12186	43	LRP1B,NRG3,TNC
3.169e-02	-3.45	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	32	ERBB4,NRG3
3.169e-02	-3.45	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	4	18204	50	ATP1A2,SLC1A3,APOE,RYR3
3.193e-02	-3.44	MAP_kinase_CS	interpro domains	IPR003527	12	1	18521	50	MAPK10
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.197e-02	-3.44	DCX	smart domains	SM00537	9	1	9717	35	DCLK2
3.199e-02	-3.44	sterol homeostasis	biological process	GO:0055092	102	2	18204	50	RORA,APOE
3.200e-02	-3.44	CLSTN1 (calsyntenin 1)	protein interactions	22883	109	2	19454	50	SLC1A3,MGAT4C
3.200e-02	-3.44	NOS1AP (nitric oxide synthase 1 adaptor protein)	protein interactions	9722	109	2	19454	50	NTRK2,GJA1
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	TRPM3,SOX5
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.211e-02	-3.44	WDR6 (WD repeat domain 6)	protein interactions	11180	270	3	19454	50	PARD3,GJA1,NTRK2
3.222e-02	-3.44	cGMP signaling	KEGG pathways	M00694	9	1	7161	26	PRKG1
3.222e-02	-3.44	cGMP signaling	KEGG pathways	hsa_M00694	9	1	7161	26	PRKG1
3.222e-02	-3.44	Heparan sulfate degradation	KEGG pathways	M00078	9	1	7161	26	HPSE2
3.222e-02	-3.44	Heparan sulfate degradation	KEGG pathways	hsa_M00078	9	1	7161	26	HPSE2
3.248e-02	-3.43	oligopeptide transmembrane transport	biological process	GO:0035672	12	1	18204	50	GJA1
3.248e-02	-3.43	regulation of gonadotropin secretion	biological process	GO:0032276	12	1	18204	50	GJA1
3.248e-02	-3.43	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	50	CST3
3.248e-02	-3.43	urea transport	biological process	GO:0015840	12	1	18204	50	SLC14A1
3.248e-02	-3.43	auditory behavior	biological process	GO:0031223	12	1	18204	50	SLC1A3
3.248e-02	-3.43	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	50	CST3
3.248e-02	-3.43	neurotransmitter-gated ion channel clustering	biological process	GO:0072578	12	1	18204	50	APOE
3.248e-02	-3.43	negative regulation of smooth muscle contraction	biological process	GO:0045986	12	1	18204	50	PRKG1
3.248e-02	-3.43	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	50	SLC1A2
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	5	ADCY2
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	5	ADCY2
3.249e-02	-3.43	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	5	ADCY2
3.249e-02	-3.43	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	5	ADCY2
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	5	ADCY2
3.250e-02	-3.43	DNA-binding transcription repressor activity, RNA polymerase II-specific	molecular function	GO:0001227	263	3	18094	48	ZBTB20,TRPS1,GLIS3
3.254e-02	-3.43	UBIAD1 (UbiA prenyltransferase domain containing 1)	protein interactions	29914	110	2	19454	50	GJA1,NTRK2
3.256e-02	-3.42	MH1	pfam domains	PF03165	12	1	17795	49	NFIA
3.271e-02	-3.42	RDX (radixin)	protein interactions	5962	272	3	19454	50	NEBL,MACF1,MAPK10
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	RORA,ATP1A2
3.284e-02	-3.42	chylomicron	cellular component	GO:0042627	13	1	19108	49	APOE
3.291e-02	-3.41	ANKH (ANKH inorganic pyrophosphate transport regulator)	protein interactions	56172	13	1	19454	50	APOE
3.291e-02	-3.41	TAS1R3 (taste 1 receptor member 3)	protein interactions	83756	13	1	19454	50	GJA1
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	NCAN (neurocan)	protein interactions	1463	13	1	19454	50	TNC
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.291e-02	-3.41	RNASE4 (ribonuclease A family member 4)	protein interactions	6038	13	1	19454	50	LRP1B
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	JAM2 (junctional adhesion molecule 2)	protein interactions	58494	13	1	19454	50	PARD3
3.299e-02	-3.41	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	32	NTM,LSAMP
3.342e-02	-3.40	TyrKc	smart domains	SM00219	80	2	9717	35	NTRK2,ERBB4
3.351e-02	-3.40	cell fate commitment	biological process	GO:0045165	257	3	18204	50	SOX5,NFIA,ERBB4
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	MACF1,TRPS1
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	GPM6A,ERBB4
3.373e-02	-3.39	cellular response to alcohol	biological process	GO:0097306	105	2	18204	50	TNC,ADCY2
3.373e-02	-3.39	gland morphogenesis	biological process	GO:0022612	105	2	18204	50	NRG3,TNC
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.392e-02	-3.38	cAMP signaling pathway	KEGG pathways	hsa04024	198	3	7161	26	MAPK10,ADCY2,ATP1A2
3.392e-02	-3.38	cAMP signaling pathway	KEGG pathways	ko04024	198	3	7161	26	ADCY2,MAPK10,ATP1A2
3.394e-02	-3.38	NAKATPASE	prints domains	PR00121	9	1	5227	20	ATP1A2
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.398e-02	-3.38	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	3	16828	48	MACF1,GLIS3,MGAT4C
3.408e-02	-3.38	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	3	18094	48	SLC1A2,SLC1A3,GJA1
3.418e-02	-3.38	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	7	19454	50	SORBS1,NHSL1,MACF1,FMN2,PITPNC1,DCLK2,PARD3
3.418e-02	-3.38	KIRREL1 (kirre like nephrin family adhesion molecule 1)	protein interactions	55243	113	2	19454	50	PARD3,GJA1
3.425e-02	-3.37	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	50	NEBL,SLC1A3,GPM6A
3.432e-02	-3.37	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	32	ERBB4,NRG3
3.432e-02	-3.37	cellular response to ketone	biological process	GO:1901655	106	2	18204	50	ADCY2,TNC
3.432e-02	-3.37	small_intestine	COSMIC cancer mutations	small_intestine	250	3	16828	48	MGAT4C,TNIK,MACF1
3.440e-02	-3.37	DNA-binding transcription factor activity	molecular function	GO:0003700	1441	8	18094	48	SOX5,ZBTB20,NFIA,GLIS3,TRPS1,NPAS3,RORA,RFX4
3.447e-02	-3.37	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	9	16828	48	GPC5,LSAMP,PRKG1,CNTN1,SOX5,ATP1A2,TRPS1,RORA,MACF1
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	SORBS1,ATP1A2
3.459e-02	-3.36	small molecule binding	molecular function	GO:0036094	6197	23	18094	48	PRKG1,ATP1A2,PITPNC1,DCLK2,NTRK2,DGKG,MACF1,RYR3,PARD3,RORA,MAPK10,SLC1A2,DTNA,GLIS3,LRP1B,ERBB4,MGAT4C,ZBTB20,ADCY2,TRPS1,APOE,TNIK,SLC1A3
3.469e-02	-3.36	negative regulation of protein metabolic process	biological process	GO:0051248	893	6	18204	50	CST3,PARD3,CLU,NTRK2,APOE,FMN2
3.474e-02	-3.36	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	50	ZBTB20,MACF1
3.474e-02	-3.36	MIP	prosite domains	PS00221	10	1	12186	43	AQP4
3.474e-02	-3.36	MIR	prosite domains	PS50919	10	1	12186	43	RYR3
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	TRPM3,RYR3
3.510e-02	-3.35	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	43	CTNNA2
3.514e-02	-3.35	glial cell fate commitment	biological process	GO:0021781	13	1	18204	50	NFIA
3.514e-02	-3.35	phospholipid efflux	biological process	GO:0033700	13	1	18204	50	APOE
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	50	PRKG1
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	50	RORA
3.514e-02	-3.35	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	50	RORA
3.514e-02	-3.35	prepulse inhibition	biological process	GO:0060134	13	1	18204	50	CTNNA2
3.514e-02	-3.35	ectodermal placode development	biological process	GO:0071696	13	1	18204	50	NRG3
3.514e-02	-3.35	olfactory bulb interneuron differentiation	biological process	GO:0021889	13	1	18204	50	ERBB4
3.514e-02	-3.35	regulation of dendritic spine maintenance	biological process	GO:1902950	13	1	18204	50	APOE
3.514e-02	-3.35	cellular response to vitamin D	biological process	GO:0071305	13	1	18204	50	TNC
3.514e-02	-3.35	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	47	16828	48	NRG3,RYR3,ERBB4,GLIS3,LRP1B,MACF1,TNC,PRKG1,NPAS3,TNIK,TRPS1,DCLK2,NTRK2,LSAMP,CDH20,ADCY2,NHSL1,PARD3,SORBS1,DTNA,TRPM3,GPC5,PITPNC1,ZBTB20,CLU,DGKG,SLC1A3,GPM6A,NTM,MSI2,RORA,SOX5,APOE,SLC14A1,CST3,NEBL,AQP4,HPSE2,SLC1A2,MGAT4C,CTNND2,RFX4,NFIA,CNTN1,GJA1,FMN2,ATP1A2
3.514e-02	-3.35	bile_duct	COSMIC cancer mutations	bile_duct	15095	47	16828	48	LSAMP,CDH20,NHSL1,ADCY2,PARD3,SORBS1,TRPM3,GPC5,DTNA,PITPNC1,ZBTB20,NRG3,RYR3,ERBB4,GLIS3,LRP1B,MACF1,TNC,NPAS3,PRKG1,TNIK,TRPS1,NTRK2,DCLK2,RFX4,CTNND2,NFIA,CNTN1,GJA1,FMN2,ATP1A2,CLU,SLC1A3,DGKG,NTM,GPM6A,RORA,MSI2,SOX5,APOE,SLC14A1,CST3,AQP4,NEBL,HPSE2,MGAT4C,SLC1A2
3.522e-02	-3.35	Ldl_recept_b	pfam domains	PF00058	13	1	17795	49	LRP1B
3.530e-02	-3.34	TBXT (T-box transcription factor T)	protein interactions	6862	115	2	19454	50	TRPS1,NFIA
3.530e-02	-3.34	CDH2 (cadherin 2)	protein interactions	1000	115	2	19454	50	PARD3,CTNND2
3.530e-02	-3.34	PLEKHA7 (pleckstrin homology domain containing A7)	protein interactions	144100	115	2	19454	50	PARD3,GJA1
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	PARD3,SOX5
3.532e-02	-3.34	chromaffin granule	cellular component	GO:0042583	14	1	19108	49	CLU
3.533e-02	-3.34	S_TKc	smart domains	SM00220	348	4	9717	35	DCLK2,TNIK,MAPK10,PRKG1
3.538e-02	-3.34	DNA-binding transcription repressor activity	molecular function	GO:0001217	272	3	18094	48	GLIS3,TRPS1,ZBTB20
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	IFNA8 (interferon alpha 8)	protein interactions	3445	14	1	19454	50	APOE
3.540e-02	-3.34	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	50	CST3
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	GAGE1 (G antigen 1)	protein interactions	2543	14	1	19454	50	PRKG1
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	ZBTB20
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	LRP1B
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.546e-02	-3.34	DAGKa	smart domains	SM00045	10	1	9717	35	DGKG
3.546e-02	-3.34	MIR	smart domains	SM00472	10	1	9717	35	RYR3
3.570e-02	-3.33	blood microparticle	cellular component	GO:0072562	116	2	19108	49	CLU,APOE
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.586e-02	-3.33	FCGRT (Fc gamma receptor and transporter)	protein interactions	2217	116	2	19454	50	CLU,CNTN1
3.586e-02	-3.33	RBBP8 (RB binding protein 8, endonuclease)	protein interactions	5932	116	2	19454	50	CLU,CTNNA2
3.603e-02	-3.32	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	3	18094	48	SLC1A2,SLC1A3,ATP1A2
3.605e-02	-3.32	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	5	ADCY2
3.609e-02	-3.32	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	48	ERBB4,PRKG1,TNIK,NTRK2
3.612e-02	-3.32	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	2	18204	50	ZBTB20,CLU
3.612e-02	-3.32	postsynapse organization	biological process	GO:0099173	109	2	18204	50	CTNND2,APOE
3.620e-02	-3.32	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	50	APOE,CTNND2,GPC5
3.627e-02	-3.32	Ion_trans	pfam domains	PF00520	109	2	17795	49	RYR3,TRPM3
3.634e-02	-3.31	tube development	biological process	GO:0035295	903	6	18204	50	APOE,NTRK2,GJA1,RORA,TNC,NFIA
3.635e-02	-3.31	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	6	19454	50	DCLK2,PARD3,MACF1,NHSL1,SORBS1,PITPNC1
3.642e-02	-3.31	ELK3 (ETS transcription factor ELK3)	protein interactions	2004	117	2	19454	50	NFIA,TRPS1
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.670e-02	-3.30	EV release from cardiac cells and their functional effects	WikiPathways	WP3297	9	1	5310	22	ERBB4
3.672e-02	-3.30	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	32	GPC5
3.672e-02	-3.30	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	32	GPC5
3.699e-02	-3.30	SIPA1L2 (signal induced proliferation associated 1 like 2)	protein interactions	57568	118	2	19454	50	GJA1,PARD3
3.699e-02	-3.30	CEACAM8 (CEA cell adhesion molecule 8)	protein interactions	1088	118	2	19454	50	CLU,APOE
3.715e-02	-3.29	regulation of multicellular organismal process	biological process	GO:0051239	3113	14	18204	50	TRPS1,MACF1,CST3,RORA,NTRK2,CLU,ERBB4,GJA1,PRKG1,ATP1A2,SOX5,APOE,PARD3,ZBTB20
3.715e-02	-3.29	LDLR_classB_rpt	interpro domains	IPR000033	14	1	18521	50	LRP1B
3.715e-02	-3.29	Aquaporin-like	interpro domains	IPR023271	14	1	18521	50	AQP4
3.715e-02	-3.29	MIP	interpro domains	IPR000425	14	1	18521	50	AQP4
3.717e-02	-3.29	regulation of phosphate metabolic process	biological process	GO:0019220	1154	7	18204	50	PRKG1,ZBTB20,PARD3,ERBB4,APOE,NTRK2,TNIK
3.720e-02	-3.29	negative regulation of transport	biological process	GO:0051051	460	4	18204	50	ATP1A2,PRKG1,APOE,GJA1
3.731e-02	-3.29	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	9	16828	48	RORA,MACF1,SORBS1,CNTN1,FMN2,DGKG,CTNND2,DTNA,CDH20
3.731e-02	-3.29	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	9	16828	48	DGKG,CDH20,DTNA,CTNND2,SORBS1,RORA,MACF1,CNTN1,FMN2
3.732e-02	-3.29	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	7	18204	50	TNIK,NTRK2,APOE,PARD3,ERBB4,ZBTB20,PRKG1
3.744e-02	-3.29	protein localization	biological process	GO:0008104	1954	10	18204	50	MACF1,TNIK,LRP1B,APOE,DCLK2,ERBB4,PARD3,CLU,FMN2,GJA1
3.756e-02	-3.28	HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1)	protein interactions	3113	119	2	19454	50	CLU,APOE
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.764e-02	-3.28	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	26	ADCY2,ATP1A2
3.779e-02	-3.28	NEDD4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	4734	494	4	19454	50	GJA1,ERBB4,TNIK,GLIS3
3.779e-02	-3.28	sodium ion export across plasma membrane	biological process	GO:0036376	14	1	18204	50	ATP1A2
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	atrial cardiac muscle cell action potential	biological process	GO:0086014	14	1	18204	50	GJA1
3.779e-02	-3.28	cellular response to forskolin	biological process	GO:1904322	14	1	18204	50	ADCY2
3.779e-02	-3.28	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	50	AQP4
3.779e-02	-3.28	neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0099645	14	1	18204	50	ERBB4
3.779e-02	-3.28	negative regulation of long-term synaptic potentiation	biological process	GO:1900272	14	1	18204	50	APOE
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	positive regulation of phospholipid transport	biological process	GO:2001140	14	1	18204	50	APOE
3.779e-02	-3.28	atrial cardiac muscle cell to AV node cell signaling	biological process	GO:0086026	14	1	18204	50	GJA1
3.779e-02	-3.28	protein localization to postsynaptic specialization membrane	biological process	GO:0099633	14	1	18204	50	ERBB4
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.779e-02	-3.28	oligopeptide transport	biological process	GO:0006857	14	1	18204	50	GJA1
3.779e-02	-3.28	adult heart development	biological process	GO:0007512	14	1	18204	50	GJA1
3.779e-02	-3.28	response to forskolin	biological process	GO:1904321	14	1	18204	50	ADCY2
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	mechanosensory behavior	biological process	GO:0007638	14	1	18204	50	SLC1A3
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.780e-02	-3.28	low-density lipoprotein particle	cellular component	GO:0034362	15	1	19108	49	APOE
3.788e-02	-3.27	DEFB123 (defensin beta 123)	protein interactions	245936	15	1	19454	50	LRP1B
3.788e-02	-3.27	PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	27344	15	1	19454	50	MGAT4C
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	NPR1 (natriuretic peptide receptor 1)	protein interactions	4881	15	1	19454	50	PRKG1
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CLU
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	OLFM3 (olfactomedin 3)	protein interactions	118427	15	1	19454	50	LRP1B
3.788e-02	-3.27	MIP	pfam domains	PF00230	14	1	17795	49	AQP4
3.788e-02	-3.27	GATA	pfam domains	PF00320	14	1	17795	49	TRPS1
3.794e-02	-3.27	rhythmic process	biological process	GO:0048511	270	3	18204	50	RORA,MAPK10,NTRK2
3.814e-02	-3.27	LRP6 (LDL receptor related protein 6)	protein interactions	4040	120	2	19454	50	GJA1,MGAT4C
3.815e-02	-3.27	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	43	TRPS1
3.815e-02	-3.27	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	43	NTRK2
3.818e-02	-3.27	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	8	16828	48	CTNND2,TRPM3,LRP1B,RYR3,ERBB4,MACF1,ATP1A2,HPSE2
3.836e-02	-3.26	cellular macromolecule localization	biological process	GO:0070727	1962	10	18204	50	CLU,PARD3,ERBB4,GJA1,FMN2,MACF1,TNIK,DCLK2,APOE,LRP1B
3.838e-02	-3.26	response to organonitrogen compound	biological process	GO:0010243	915	6	18204	50	SLC1A2,SLC1A3,TNIK,GJA1,RYR3,SORBS1
3.855e-02	-3.26	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	2	18094	48	SLC1A3,SLC1A2
3.856e-02	-3.26	heart process	biological process	GO:0003015	113	2	18204	50	ATP1A2,GJA1
3.856e-02	-3.26	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	2	18204	50	ZBTB20,CLU
3.882e-02	-3.25	Arrhythmogenic Right Ventricular Cardiomyopathy	WikiPathways	WP2118	76	2	5310	22	CTNNA2,GJA1
3.884e-02	-3.25	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	47	16828	48	LSAMP,CDH20,NHSL1,ADCY2,PARD3,NKAIN3,SORBS1,TRPM3,GPC5,DTNA,PITPNC1,ZBTB20,NRG3,RYR3,ERBB4,GLIS3,LRP1B,MACF1,TNC,NPAS3,PRKG1,TNIK,TRPS1,NTRK2,DCLK2,RFX4,CTNND2,NFIA,CNTN1,GJA1,FMN2,ATP1A2,CLU,DGKG,SLC1A3,NTM,GPM6A,RORA,MSI2,SOX5,APOE,SLC14A1,NEBL,AQP4,HPSE2,MGAT4C,SLC1A2
3.896e-02	-3.25	EGF_2	prosite domains	PS01186	213	3	12186	43	TNC,LRP1B,NRG3
3.898e-02	-3.24	cytoskeleton	cellular component	GO:0005856	2412	11	19108	49	MACF1,CTNNA2,NEBL,TNIK,FMN2,SORBS1,PARD3,DGKG,CLU,GJA1,DTNA
3.898e-02	-3.24	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	3	16828	48	SOX5,RYR3,SLC1A2
3.908e-02	-3.24	low-density lipoprotein particle receptor activity	molecular function	GO:0005041	15	1	18094	48	LRP1B
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.908e-02	-3.24	filamin binding	molecular function	GO:0031005	15	1	18094	48	NEBL
3.908e-02	-3.24	efflux transmembrane transporter activity	molecular function	GO:0015562	15	1	18094	48	GJA1
3.908e-02	-3.24	tropomyosin binding	molecular function	GO:0005523	15	1	18094	48	NEBL
3.910e-02	-3.24	EPB41L5 (erythrocyte membrane protein band 4.1 like 5)	protein interactions	57669	292	3	19454	50	GJA1,NTRK2,PARD3
3.912e-02	-3.24	regulation of developmental process	biological process	GO:0050793	2540	12	18204	50	NTRK2,APOE,SOX5,RORA,TNIK,CST3,MACF1,TRPS1,DGKG,GJA1,ERBB4,PARD3
3.913e-02	-3.24	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	2	10285	32	GPC5,APOE
3.915e-02	-3.24	tube morphogenesis	biological process	GO:0035239	685	5	18204	50	TNC,RORA,GJA1,APOE,NTRK2
3.918e-02	-3.24	negative regulation of protein catabolic process	biological process	GO:0042177	114	2	18204	50	FMN2,CST3
3.918e-02	-3.24	negative regulation of small molecule metabolic process	biological process	GO:0062014	114	2	18204	50	APOE,PRKG1
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	DTNA,NHSL1
3.934e-02	-3.24	SH3DOMAIN	prints domains	PR00452	83	2	5227	20	SORBS1,NEBL
3.935e-02	-3.24	skin-acral-malignant_melanoma	COSMIC cancer mutations	skin-acral-malignant_melanoma	264	3	16828	48	PARD3,CDH20,FMN2
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.956e-02	-3.23	import into cell	biological process	GO:0098657	687	5	18204	50	LRP1B,APOE,SLC1A3,ATP1A2,SLC1A2
3.959e-02	-3.23	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	5	RORA
3.972e-02	-3.23	Passive transport by Aquaporins	REACTOME pathways	R-HSA-432047	13	1	10285	32	AQP4
3.975e-02	-3.23	Diacylglycerol_kinase_cat_dom	interpro domains	IPR001206	15	1	18521	50	DGKG
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.988e-02	-3.22	EF_HAND_2	prosite domains	PS50222	215	3	12186	43	DGKG,MACF1,RYR3
3.988e-02	-3.22	PAX7 (paired box 7)	protein interactions	5081	123	2	19454	50	NFIA,TRPS1
4.008e-02	-3.22	learning or memory	biological process	GO:0007611	276	3	18204	50	ATP1A2,APOE,NTRK2
4.019e-02	-3.21	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	8	16828	48	RYR3,LRP1B,TRPM3,CTNND2,HPSE2,ATP1A2,MACF1,ERBB4
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	MACF1
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKG1
4.035e-02	-3.21	TMEM134 (transmembrane protein 134)	protein interactions	80194	16	1	19454	50	ERBB4
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	CYP2C8 (cytochrome P450 family 2 subfamily C member 8)	protein interactions	1558	16	1	19454	50	APOE
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.043e-02	-3.21	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	50	RORA
4.043e-02	-3.21	negative regulation of amino acid transport	biological process	GO:0051956	15	1	18204	50	PRKG1
4.043e-02	-3.21	pyramidal neuron differentiation	biological process	GO:0021859	15	1	18204	50	DCLK2
4.043e-02	-3.21	columnar/cuboidal epithelial cell maturation	biological process	GO:0002069	15	1	18204	50	GJA1
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	collateral sprouting	biological process	GO:0048668	15	1	18204	50	PRKG1
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	exit from mitosis	biological process	GO:0010458	15	1	18204	50	NFIA
4.043e-02	-3.21	synapse maturation	biological process	GO:0060074	15	1	18204	50	NFIA
4.043e-02	-3.21	atrial cardiac muscle cell to AV node cell communication	biological process	GO:0086066	15	1	18204	50	GJA1
4.043e-02	-3.21	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	50	SORBS1
4.043e-02	-3.21	lipoprotein catabolic process	biological process	GO:0042159	15	1	18204	50	APOE
4.043e-02	-3.21	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	50	MACF1
4.043e-02	-3.21	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	50	NTRK2
4.043e-02	-3.21	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	1	18204	50	PRKG1
4.043e-02	-3.21	regulation of phospholipid transport	biological process	GO:2001138	15	1	18204	50	APOE
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	50	NTRK2
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	positive regulation of cholesterol metabolic process	biological process	GO:0090205	15	1	18204	50	APOE
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	FMN2
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	DAGK_cat	pfam domains	PF00781	15	1	17795	49	DGKG
4.055e-02	-3.21	positive regulation of MAPK cascade	biological process	GO:0043410	473	4	18204	50	TNIK,ERBB4,NTRK2,APOE
4.069e-02	-3.20	LZTS2 (leucine zipper tumor suppressor 2)	protein interactions	84445	506	4	19454	50	PARD3,NEBL,SORBS1,GJA1
4.070e-02	-3.20	Composition of Lipid Particles	WikiPathways	WP3601	10	1	5310	22	APOE
4.079e-02	-3.20	SP7 (Sp7 transcription factor)	protein interactions	121340	297	3	19454	50	SOX5,NFIA,TRPS1
4.080e-02	-3.20	actin filament organization	biological process	GO:0007015	278	3	18204	50	SORBS1,FMN2,NEBL
4.083e-02	-3.20	-	gene3d domains	2.60.200.40	14	1	14470	43	DGKG
4.083e-02	-3.20	-	gene3d domains	2.20.25.10	14	1	14470	43	TNC
4.083e-02	-3.20	Glycerol uptake facilitator protein	gene3d domains	1.20.1080.10	14	1	14470	43	AQP4
4.085e-02	-3.20	acral	COSMIC cancer mutations	acral	268	3	16828	48	PARD3,FMN2,CDH20
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	NTM,CNTN1,LSAMP,NTRK2
4.106e-02	-3.19	STXBP1 (syntaxin binding protein 1)	protein interactions	6812	125	2	19454	50	GJA1,GPM6A
4.106e-02	-3.19	UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats)	protein interactions	55075	125	2	19454	50	PARD3,GJA1
4.126e-02	-3.19	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	32	RYR3,TRPM3
4.155e-02	-3.18	MAPK	prosite domains	PS01351	12	1	12186	43	MAPK10
4.155e-02	-3.18	CNMP_BINDING_2	prosite domains	PS00889	12	1	12186	43	PRKG1
4.163e-02	-3.18	MAP kinase kinase activity	molecular function	GO:0004708	16	1	18094	48	MAPK10
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.163e-02	-3.18	cGMP binding	molecular function	GO:0030553	16	1	18094	48	PRKG1
4.163e-02	-3.18	MAP kinase activity	molecular function	GO:0004707	16	1	18094	48	MAPK10
4.163e-02	-3.18	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	48	ADCY2
4.163e-02	-3.18	water channel activity	molecular function	GO:0015250	16	1	18094	48	AQP4
4.163e-02	-3.18	misfolded protein binding	molecular function	GO:0051787	16	1	18094	48	CLU
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.193e-02	-3.17	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	50	MAPK10,SORBS1,NRG3,NFIA,ERBB4,NTRK2,CTNND2,CNTN1,TNIK,MACF1
4.216e-02	-3.17	ARRB1 (arrestin beta 1)	protein interactions	408	301	3	19454	50	MAPK10,LRP1B,DGKG
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	NFIA,TRPS1
4.235e-02	-3.16	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	50	PRKG1
4.240e-02	-3.16	ZnF_GATA	smart domains	SM00401	12	1	9717	35	TRPS1
4.240e-02	-3.16	DWA	smart domains	SM00523	12	1	9717	35	NFIA
4.265e-02	-3.15	Wnt signaling pathway	biological process	GO:0016055	283	3	18204	50	TNIK,MACF1,CTNND2
4.267e-02	-3.15	neuron projection terminus	cellular component	GO:0044306	128	2	19108	49	NTRK2,SLC1A2
4.271e-02	-3.15	regulation of response to stimulus	biological process	GO:0048583	4104	17	18204	50	PRKG1,GJA1,MAPK10,SORBS1,FMN2,ERBB4,CLU,CTNND2,NTRK2,RORA,MACF1,TNIK,CTNNA2,DGKG,GPC5,TNC,APOE
4.273e-02	-3.15	apical dendrite	cellular component	GO:0097440	17	1	19108	49	CLU
4.273e-02	-3.15	protein complex involved in cell-matrix adhesion	cellular component	GO:0098637	17	1	19108	49	TNC
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	C16orf92 (chromosome 16 open reading frame 92)	protein interactions	146378	17	1	19454	50	APOE
4.282e-02	-3.15	DENND5B (DENN domain containing 5B)	protein interactions	160518	17	1	19454	50	GJA1
4.282e-02	-3.15	CNTN2 (contactin 2)	protein interactions	6900	17	1	19454	50	CNTN1
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	SHD (Src homology 2 domain containing transforming protein D)	protein interactions	56961	17	1	19454	50	ERBB4
4.282e-02	-3.15	SCN1B (sodium voltage-gated channel beta subunit 1)	protein interactions	6324	17	1	19454	50	CNTN1
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	FLRT3 (fibronectin leucine rich transmembrane protein 3)	protein interactions	23767	17	1	19454	50	GJA1
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.286e-02	-3.15	MYB (MYB proto-oncogene, transcription factor)	protein interactions	4602	128	2	19454	50	TRPS1,NFIA
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.286e-02	-3.15	TEAD2 (TEA domain transcription factor 2)	protein interactions	8463	128	2	19454	50	ZBTB20,TRPS1
4.286e-02	-3.15	STIM2 (stromal interaction molecule 2)	protein interactions	57620	128	2	19454	50	GJA1,PRKG1
4.286e-02	-3.15	SH3BP4 (SH3 domain binding protein 4)	protein interactions	23677	128	2	19454	50	GJA1,PARD3
4.286e-02	-3.15	FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1)	protein interactions	10160	128	2	19454	50	GJA1,PARD3
4.297e-02	-3.15	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	6	19454	50	GJA1,PARD3,SLC1A3,FMN2,MACF1,DTNA
4.307e-02	-3.14	positive regulation of membrane protein ectodomain proteolysis	biological process	GO:0051044	16	1	18204	50	APOE
4.307e-02	-3.14	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	50	SLC1A3
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	low-density lipoprotein particle remodeling	biological process	GO:0034374	16	1	18204	50	APOE
4.311e-02	-3.14	human chr2q34	chromosome location	human chr2q34	23	1	26134	50	ERBB4
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.313e-02	-3.14	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	5	ATP1A2
4.313e-02	-3.14	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	5	ATP1A2
4.319e-02	-3.14	SH3	prosite domains	PS50002	222	3	12186	43	NEBL,MACF1,SORBS1
4.333e-02	-3.14	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	43	ERBB4,NTRK2
4.337e-02	-3.14	positive regulation of metabolic process	biological process	GO:0009893	3796	16	18204	50	NPAS3,APOE,GLIS3,ZBTB20,TNC,NTRK2,RORA,TNIK,CNTN1,RFX4,SORBS1,FMN2,GJA1,ERBB4,NFIA,CLU
4.344e-02	-3.14	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	2	10285	32	SLC1A2,SLC1A3
4.345e-02	-3.14	protein tyrosine kinase binding	molecular function	GO:1990782	125	2	18094	48	NRG3,GJA1
4.346e-02	-3.14	Progesterone-mediated oocyte maturation	KEGG pathways	hsa04914	92	2	7161	26	MAPK10,ADCY2
4.346e-02	-3.14	Progesterone-mediated oocyte maturation	KEGG pathways	ko04914	92	2	7161	26	ADCY2,MAPK10
4.346e-02	-3.14	GnRH signaling pathway	KEGG pathways	hsa04912	92	2	7161	26	MAPK10,ADCY2
4.346e-02	-3.14	GnRH signaling pathway	KEGG pathways	ko04912	92	2	7161	26	MAPK10,ADCY2
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	ZBTB20,SOX5
4.346e-02	-3.14	SLC38A2 (solute carrier family 38 member 2)	protein interactions	54407	129	2	19454	50	PARD3,GJA1
4.352e-02	-3.13	homeostatic process	biological process	GO:0042592	1456	8	18204	50	SLC1A3,GJA1,RYR3,ZBTB20,ATP1A2,RORA,APOE,AQP4
4.368e-02	-3.13	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	43	FMN2
4.388e-02	-3.13	Z disc	cellular component	GO:0030018	130	2	19108	49	RYR3,NEBL
4.407e-02	-3.12	DVL1 (dishevelled segment polarity protein 1)	protein interactions	1855	130	2	19454	50	GJA1,PARD3
4.423e-02	-3.12	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	5	16828	48	MACF1,PARD3,ZBTB20,LRP1B,NRG3
4.423e-02	-3.12	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	5	16828	48	LRP1B,NRG3,ZBTB20,MACF1,PARD3
4.424e-02	-3.12	Ig-like_fold	interpro domains	IPR013783	721	5	18521	50	TNC,CNTN1,NTM,NTRK2,LSAMP
4.449e-02	-3.11	tight junction	cellular component	GO:0070160	131	2	19108	49	PARD3,GJA1
4.453e-02	-3.11	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	45	16828	48	ATP1A2,FMN2,GJA1,CNTN1,NFIA,RFX4,CTNND2,MGAT4C,SLC1A2,HPSE2,AQP4,NEBL,SLC14A1,SOX5,RORA,NTM,GPM6A,SLC1A3,DGKG,CLU,ZBTB20,PITPNC1,GPC5,TRPM3,DTNA,NKAIN3,SORBS1,PARD3,NHSL1,ADCY2,CDH20,LSAMP,NTRK2,DCLK2,TRPS1,TNIK,NPAS3,PRKG1,TNC,MACF1,LRP1B,GLIS3,ERBB4,RYR3,NRG3
4.468e-02	-3.11	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	50	NFIA,RORA
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	SOX5,NFIA
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	NFIA,SOX5
4.492e-02	-3.10	muscle cell differentiation	biological process	GO:0042692	289	3	18204	50	NEBL,PRKG1,RORA
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY2
4.493e-02	-3.10	NAD/diacylglycerol_kinase_sf	interpro domains	IPR016064	17	1	18521	50	DGKG
4.493e-02	-3.10	ATP-NAD_kinase_N	interpro domains	IPR017438	17	1	18521	50	DGKG
4.493e-02	-3.10	Cystatin_dom	interpro domains	IPR000010	17	1	18521	50	CST3
4.494e-02	-3.10	LDLRB	prosite domains	PS51120	13	1	12186	43	LRP1B
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	ZNF224 (zinc finger protein 224)	protein interactions	7767	18	1	19454	50	LRP1B
4.529e-02	-3.09	Lck (lymphocyte protein tyrosine kinase)	protein interactions	16818	18	1	19454	50	APOE
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	PARD3
4.529e-02	-3.09	SHISA2 (shisa family member 2)	protein interactions	387914	18	1	19454	50	GJA1
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKG1
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.530e-02	-3.09	PHLDB2 (pleckstrin homology like domain family B member 2)	protein interactions	90102	132	2	19454	50	PARD3,GJA1
4.533e-02	-3.09	purine ribonucleoside triphosphate binding	molecular function	GO:0035639	1804	9	18094	48	ADCY2,ERBB4,MAPK10,ATP1A2,PRKG1,TNIK,DGKG,NTRK2,DCLK2
4.560e-02	-3.09	cardiocyte differentiation	biological process	GO:0035051	124	2	18204	50	PRKG1,NEBL
4.567e-02	-3.09	inorganic ion transmembrane transport	biological process	GO:0098660	715	5	18204	50	ATP1A2,GPM6A,SLC1A3,TRPM3,RYR3
4.570e-02	-3.09	N-Glycan antennae elongation	REACTOME pathways	R-HSA-975577	15	1	10285	32	MGAT4C
4.570e-02	-3.09	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	32	ADCY2
4.570e-02	-3.09	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	32	ADCY2
4.570e-02	-3.09	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	50	ERBB4
4.570e-02	-3.09	viral genome replication	biological process	GO:0019079	17	1	18204	50	NFIA
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	TNIK
4.570e-02	-3.09	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	50	CLU
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	50	NTRK2
4.570e-02	-3.09	regulation of trophoblast cell migration	biological process	GO:1901163	17	1	18204	50	GJA1
4.570e-02	-3.09	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	50	RORA
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	high-density lipoprotein particle remodeling	biological process	GO:0034375	17	1	18204	50	APOE
4.570e-02	-3.09	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	50	SORBS1
4.570e-02	-3.09	branch elongation of an epithelium	biological process	GO:0060602	17	1	18204	50	TNC
4.570e-02	-3.09	positive regulation of vascular permeability	biological process	GO:0043117	17	1	18204	50	APOE
4.570e-02	-3.09	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	50	CTNNA2
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	negative regulation of triglyceride metabolic process	biological process	GO:0090209	17	1	18204	50	APOE
4.570e-02	-3.09	ureter development	biological process	GO:0072189	17	1	18204	50	NFIA
4.570e-02	-3.09	cGMP metabolic process	biological process	GO:0046068	17	1	18204	50	RORA
4.570e-02	-3.09	fatty acid homeostasis	biological process	GO:0055089	17	1	18204	50	APOE
4.581e-02	-3.08	ZZ	pfam domains	PF00569	17	1	17795	49	DTNA
4.581e-02	-3.08	Cystatin	pfam domains	PF00031	17	1	17795	49	CST3
4.598e-02	-3.08	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	48	CTNND2,FMN2
4.605e-02	-3.08	Pancreatic secretion	KEGG pathways	ko04972	95	2	7161	26	ATP1A2,ADCY2
4.605e-02	-3.08	Pancreatic secretion	KEGG pathways	hsa04972	95	2	7161	26	ADCY2,ATP1A2
4.605e-02	-3.08	Endocrine resistance	KEGG pathways	hsa01522	95	2	7161	26	ADCY2,MAPK10
4.605e-02	-3.08	Endocrine resistance	KEGG pathways	ko01522	95	2	7161	26	ADCY2,MAPK10
4.607e-02	-3.08	ACTN1 (actinin alpha 1)	protein interactions	87	312	3	19454	50	GJA1,CLU,NEBL
4.626e-02	-3.07	cellular anatomical entity morphogenesis	biological process	GO:0032989	125	2	18204	50	NEBL,CNTN1
4.626e-02	-3.07	cellular component assembly involved in morphogenesis	biological process	GO:0010927	125	2	18204	50	CNTN1,NEBL
4.626e-02	-3.07	actomyosin structure organization	biological process	GO:0031032	125	2	18204	50	SORBS1,NEBL
4.631e-02	-3.07	cellular response to growth factor stimulus	biological process	GO:0071363	494	4	18204	50	NTRK2,SOX5,ERBB4,NFIA
4.649e-02	-3.07	positive regulation of gene expression	biological process	GO:0010628	1212	7	18204	50	GJA1,ZBTB20,CLU,TNC,RORA,NTRK2,CNTN1
4.653e-02	-3.07	EGFR (epidermal growth factor receptor)	protein interactions	1956	3105	13	19454	50	CLU,NTRK2,GJA1,CTNND2,TRPS1,SORBS1,TNIK,DTNA,TRPM3,CTNNA2,TNC,PARD3,ERBB4
4.665e-02	-3.07	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	5	ATP1A2
4.667e-02	-3.06	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	48	CDH20,DTNA
4.671e-02	-3.06	lipoprotein particle receptor activity	molecular function	GO:0030228	18	1	18094	48	LRP1B
4.671e-02	-3.06	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	48	NRG3
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.671e-02	-3.06	GABA receptor binding	molecular function	GO:0050811	18	1	18094	48	ERBB4
4.671e-02	-3.06	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	48	RYR3
4.674e-02	-3.06	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	5	19454	50	SLC1A2,MSI2,CLU,ERBB4,NTRK2
4.693e-02	-3.06	limbic system development	biological process	GO:0021761	126	2	18204	50	ATP1A2,DCLK2
4.716e-02	-3.05	FOXP1 (forkhead box P1)	protein interactions	27086	135	2	19454	50	SOX5,NFIA
4.716e-02	-3.05	SOX15 (SRY-box transcription factor 15)	protein interactions	6665	135	2	19454	50	TRPS1,NFIA
4.725e-02	-3.05	regulation of ERK1 and ERK2 cascade	biological process	GO:0070372	295	3	18204	50	APOE,NTRK2,ERBB4
4.746e-02	-3.05	Growth_fac_rcpt_cys_sf	interpro domains	IPR009030	129	2	18521	50	ERBB4,LRP1B
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY2
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY2
4.752e-02	-3.05	Furin_repeat	interpro domains	IPR006212	18	1	18521	50	ERBB4
4.752e-02	-3.05	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	1	18521	50	ATP1A2
4.754e-02	-3.05	ZYX (zyxin)	protein interactions	7791	316	3	19454	50	MACF1,NEBL,SORBS1
4.760e-02	-3.05	response to amino acid	biological process	GO:0043200	127	2	18204	50	NTRK2,SLC1A2
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.774e-02	-3.04	HBEGF (heparin binding EGF like growth factor)	protein interactions	1839	19	1	19454	50	ERBB4
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	EGFL6 (EGF like domain multiple 6)	protein interactions	25975	19	1	19454	50	LRP1B
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	CNTN1
4.774e-02	-3.04	Trp53 (transformation related protein 53)	protein interactions	22059	19	1	19454	50	MAPK10
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	DEFB125 (defensin beta 125)	protein interactions	245938	19	1	19454	50	GJA1
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	PCDH19 (protocadherin 19)	protein interactions	57526	19	1	19454	50	GJA1
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	ZNF532 (zinc finger protein 532)	protein interactions	55205	19	1	19454	50	ERBB4
4.781e-02	-3.04	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	2	7161	26	MAPK10,ADCY2
4.781e-02	-3.04	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	2	7161	26	ADCY2,MAPK10
4.802e-02	-3.04	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	48	16828	48	NFIA,RFX4,CTNND2,CNTN1,GJA1,ATP1A2,FMN2,DGKG,SLC1A3,CLU,SOX5,APOE,RORA,MSI2,NTM,GPM6A,HPSE2,NEBL,AQP4,CST3,SLC14A1,MGAT4C,SLC1A2,CDH20,LSAMP,NKAIN3,SORBS1,PARD3,NHSL1,ADCY2,ZBTB20,PITPNC1,TRPM3,GPC5,DTNA,ERBB4,RYR3,NRG3,TNC,MACF1,LRP1B,GLIS3,TNIK,NPAS3,PRKG1,NTRK2,DCLK2,TRPS1
4.804e-02	-3.04	skeletal system development	biological process	GO:0001501	500	4	18204	50	TRPS1,NFIA,GJA1,SOX5
4.831e-02	-3.03	regulation of signaling	biological process	GO:0023051	3534	15	18204	50	GPC5,DGKG,ATP1A2,APOE,CLU,SLC1A3,ERBB4,SORBS1,GJA1,NRG3,TNIK,MACF1,RORA,NTRK2,CTNND2
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.832e-02	-3.03	positive regulation of myelination	biological process	GO:0031643	18	1	18204	50	PARD3
4.832e-02	-3.03	myelin maintenance	biological process	GO:0043217	18	1	18204	50	CLU
4.832e-02	-3.03	regulation of protein kinase C signaling	biological process	GO:0090036	18	1	18204	50	DGKG
4.832e-02	-3.03	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	50	CST3
4.832e-02	-3.03	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	50	NEBL
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	response to misfolded protein	biological process	GO:0051788	18	1	18204	50	CLU
4.832e-02	-3.03	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	50	NTRK2
4.842e-02	-3.03	CDC42BPA (CDC42 binding protein kinase alpha)	protein interactions	8476	137	2	19454	50	GJA1,PARD3
4.844e-02	-3.03	FCERI mediated MAPK activation	REACTOME pathways	R-HSA-2871796	265	3	10285	32	ERBB4,MAPK10,NRG3
4.844e-02	-3.03	Cation_ATPase_N	pfam domains	PF00690	18	1	17795	49	ATP1A2
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY2
4.856e-02	-3.02	protein-folding chaperone binding	molecular function	GO:0051087	133	2	18094	48	CLU,ATP1A2
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.865e-02	-3.02	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	22	RYR3
4.867e-02	-3.02	Rap1 signalling	REACTOME pathways	R-HSA-392517	16	1	10285	32	PRKG1
4.867e-02	-3.02	PKA activation	REACTOME pathways	R-HSA-163615	16	1	10285	32	ADCY2
4.900e-02	-3.02	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-medullomyoblastoma	485	4	16828	48	LSAMP,LRP1B,CNTN1,RYR3
4.900e-02	-3.02	medullomyoblastoma	COSMIC cancer mutations	medullomyoblastoma	485	4	16828	48	RYR3,CNTN1,LRP1B,LSAMP
4.905e-02	-3.01	STAM2 (signal transducing adaptor molecule 2)	protein interactions	10254	138	2	19454	50	GJA1,NTRK2
4.905e-02	-3.01	regulation of cell communication	biological process	GO:0010646	3541	15	18204	50	NRG3,SORBS1,GJA1,ERBB4,SLC1A3,CLU,CTNND2,NTRK2,RORA,MACF1,TNIK,DGKG,GPC5,APOE,ATP1A2
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.930e-02	-3.01	LY	smart domains	SM00135	14	1	9717	35	LRP1B
4.930e-02	-3.01	DAGKc	smart domains	SM00046	14	1	9717	35	DGKG
4.930e-02	-3.01	CNH	smart domains	SM00036	14	1	9717	35	TNIK
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	SORBS1,MACF1,DTNA
4.946e-02	-3.01	knee	COSMIC cancer mutations	knee	125	2	16828	48	CNTN1,ERBB4
4.951e-02	-3.01	monoatomic cation homeostasis	biological process	GO:0055080	505	4	18204	50	ATP1A2,SLC1A3,RYR3,APOE
4.959e-02	-3.00	Choline metabolism in cancer	KEGG pathways	hsa05231	99	2	7161	26	MAPK10,DGKG
4.959e-02	-3.00	Choline metabolism in cancer	KEGG pathways	ko05231	99	2	7161	26	DGKG,MAPK10
4.963e-02	-3.00	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	3	16828	48	PRKG1,NRG3,SLC1A2
4.963e-02	-3.00	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	3	16828	48	SLC1A2,NRG3,PRKG1
4.968e-02	-3.00	NEFM (neurofilament medium chain)	protein interactions	4741	139	2	19454	50	APOE,TNIK
4.968e-02	-3.00	SPCS2 (signal peptidase complex subunit 2)	protein interactions	9789	139	2	19454	50	GPC5,MGAT4C
4.968e-02	-3.00	ULK1 (unc-51 like autophagy activating kinase 1)	protein interactions	8408	139	2	19454	50	CLU,GJA1
4.983e-02	-3.00	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	49	ERBB4,NTRK2