Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
6.200e-09	-18.90	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	45	16828	49	TRPS1,PREX2,DTNA,ABLIM1,NTM,HIF3A,NPAS3,PARD3,ZBTB20,PITPNC1,SFXN5,MAML2,LSAMP,NHSL1,SLC1A3,RFX4,PRKG1,SOX5,CTNND2,NKAIN3,FGFR3,ATP13A4,PTPRZ1,ERBB4,GPC5,GLIS3,TNIK,RORA,LRIG1,GPM6A,PARD3B,SPARCL1,NFIA,MACF1,CDH20,RYR3,MSI2,FBXL7,TRPM3,SLC4A4,SORBS1,BMPR1B,ZNRF3,CLU,SLC1A2
9.808e-09	-18.44	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	16	19454	50	SPARCL1,TRPM3,NHSL1,CLU,MACF1,SLC4A4,MAML2,ATP1A2,ABLIM1,TRPS1,PTPRZ1,GPM6A,MSI2,LSAMP,SLC1A3,SORBS1
1.540e-08	-17.99	nervous system development	biological process	GO:0007399	2185	22	18204	50	PTPRZ1,CLU,TNIK,BMPR1B,GPM6A,SLC1A2,CTNNA2,PREX2,SLC1A3,NTM,PARD3,ERBB4,SOX5,PRKG1,ATP1A2,RORA,LSAMP,RFX4,CTNND2,LRIG1,MSI2,NFIA
1.790e-08	-17.84	lymph_node	COSMIC cancer mutations	lymph_node	1703	20	16828	49	SLC1A3,TRPS1,PARD3B,GPM6A,ACSS1,ATP13A4,FGFR3,SOX5,CTNND2,TRPM3,PRKG1,ERBB4,PARD3,DTNA,RYR3,LSAMP,TNIK,MAML2,SFXN5,GPC5
2.751e-08	-17.41	cell morphogenesis	biological process	GO:0000902	687	13	18204	50	GPM6A,CTNND2,CTNNA2,NFIA,PTPRZ1,SLC1A3,PREX2,CDH20,CLU,TNIK,PARD3,BMPR1B,PRKG1
4.928e-08	-16.83	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	39	16828	49	TNIK,SLC1A2,RORA,LRIG1,GPC5,ZNRF3,ERBB4,SORBS1,PTPRZ1,CST3,FGFR3,ATP13A4,SLC4A4,PRKG1,RFX4,TRPM3,CTNND2,SOX5,FBXL7,NHSL1,RYR3,LSAMP,PITPNC1,MAML2,SFXN5,PARD3,ZBTB20,DTNA,HIF3A,NTM,ABLIM1,MACF1,CDH20,PREX2,PARD3B,TRPS1,ACSS1,ATP1A2,GPM6A
9.120e-08	-16.21	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	11	16828	49	ATP13A4,PRKG1,TRPM3,CTNND2,GPM6A,RYR3,LSAMP,GPC5,MAML2,SFXN5,ERBB4
1.057e-07	-16.06	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	16	16828	49	NPAS3,ERBB4,PARD3,BMPR1B,LSAMP,RYR3,SLC1A2,TNIK,ATP1A2,FBXL7,FGFR3,NKAIN3,SOX5,PRKG1,PREX2,NFIA
1.057e-07	-16.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	16	16828	49	FGFR3,NKAIN3,SOX5,PRKG1,NFIA,PREX2,ATP1A2,FBXL7,LSAMP,RYR3,SLC1A2,TNIK,ERBB4,BMPR1B,PARD3,NPAS3
1.314e-07	-15.84	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	21	16828	49	FBXL7,NHSL1,GPM6A,SLC1A3,CTNND2,SOX5,PRKG1,PREX2,RFX4,ATP13A4,NKAIN3,BMPR1B,NPAS3,PARD3,ERBB4,MAML2,GPC5,RYR3,LSAMP,SLC1A2,LRIG1
1.314e-07	-15.84	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	21	16828	49	NKAIN3,ATP13A4,RFX4,PRKG1,PREX2,SOX5,CTNND2,SLC1A3,GPM6A,NHSL1,FBXL7,SLC1A2,LRIG1,LSAMP,RYR3,GPC5,MAML2,BMPR1B,PARD3,NPAS3,ERBB4
2.237e-07	-15.31	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	24	16828	49	MAML2,SFXN5,RYR3,LSAMP,HIF3A,PARD3,PREX2,GPM6A,TRPS1,PARD3B,GPC5,LRIG1,SLC1A2,ZNRF3,ERBB4,CTNND2,TRPM3,SOX5,PRKG1,RFX4,ATP13A4,NKAIN3,FBXL7,SLC1A3
2.486e-07	-15.21	brainstem	COSMIC cancer mutations	brainstem	3102	25	16828	49	PRKG1,CTNND2,SOX5,FGFR3,NKAIN3,ATP13A4,FBXL7,SLC1A3,GPC5,TNIK,SLC1A2,RORA,PTPRZ1,ZNRF3,ERBB4,PREX2,CDH20,GPM6A,MAML2,SFXN5,RYR3,LSAMP,PARD3,NPAS3,ZBTB20
2.687e-07	-15.13	cell periphery	cellular component	GO:0071944	6020	33	19108	49	BMPR1B,GPM6A,SLC4A4,FGFR3,TRPM3,GPC5,SLC1A3,SORBS1,CLU,PRKG1,ATP1A2,ERBB4,CDH20,ZNRF3,PARD3,TNIK,LRIG1,CTNNA2,DTNA,HIF3A,NKAIN3,LSAMP,SLC1A2,CTNND2,RYR3,PARD3B,CST3,MACF1,PTPRZ1,PREX2,NTM,SPARCL1,ATP13A4
2.811e-07	-15.08	generation of neurons	biological process	GO:0048699	1158	15	18204	50	NTM,PTPRZ1,SLC1A3,PREX2,SOX5,PARD3,ERBB4,BMPR1B,TNIK,PRKG1,RORA,GPM6A,CTNND2,CTNNA2,NFIA
2.862e-07	-15.07	neurogenesis	biological process	GO:0022008	1334	16	18204	50	TNIK,BMPR1B,SOX5,PARD3,ERBB4,PRKG1,PREX2,SLC1A3,PTPRZ1,NTM,CLU,CTNNA2,NFIA,GPM6A,RORA,CTNND2
5.795e-07	-14.36	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	22	16828	49	CDH20,PREX2,GPM6A,LSAMP,RYR3,SFXN5,MAML2,ZBTB20,PARD3,ATP13A4,NKAIN3,CTNND2,SOX5,PRKG1,SLC1A3,FBXL7,RORA,TNIK,GPC5,ZNRF3,ERBB4,PTPRZ1
6.051e-07	-14.32	multicellular organism development	biological process	GO:0007275	3957	27	18204	50	ZNRF3,RFX4,CTNND2,LSAMP,RORA,ATP1A2,TRPS1,NFIA,MSI2,FGFR3,LRIG1,CDH20,NTM,PREX2,SLC1A3,PRKG1,PARD3,ERBB4,SOX5,SLC1A2,GPM6A,CTNNA2,CLU,HIF3A,PTPRZ1,BMPR1B,TNIK
6.193e-07	-14.29	anatomical structure morphogenesis	biological process	GO:0009653	2225	20	18204	50	GPM6A,RORA,CTNND2,ABLIM1,LRIG1,CTNNA2,FGFR3,NFIA,SLC1A3,PTPRZ1,PREX2,HIF3A,CDH20,CLU,TNIK,SOX5,PARD3,BMPR1B,ERBB4,PRKG1
6.436e-07	-14.26	plasma membrane	cellular component	GO:0005886	5538	31	19108	49	SORBS1,SLC1A3,LRIG1,TNIK,PARD3,ZNRF3,ERBB4,ATP1A2,CDH20,PRKG1,SLC4A4,FGFR3,GPM6A,BMPR1B,GPC5,TRPM3,PTPRZ1,PARD3B,MACF1,CST3,RYR3,CTNND2,ATP13A4,NTM,PREX2,NKAIN3,HIF3A,DTNA,CTNNA2,SLC1A2,LSAMP
7.587e-07	-14.09	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	38	16828	49	ERBB4,PTPRZ1,SORBS1,SLC1A2,RORA,LRIG1,GLIS3,TNIK,GPC5,SLC1A3,NHSL1,FBXL7,SLC4A4,ATP13A4,NKAIN3,FGFR3,SOX5,TRPM3,CTNND2,RFX4,PRKG1,ZBTB20,NPAS3,PARD3,NTM,ABLIM1,RYR3,LSAMP,SFXN5,MAML2,PITPNC1,TRPS1,PARD3B,GPM6A,ACSS1,MACF1,PREX2,NFIA
7.801e-07	-14.06	neuron differentiation	biological process	GO:0030182	1081	14	18204	50	PRKG1,BMPR1B,ERBB4,PARD3,TNIK,NTM,PTPRZ1,SLC1A3,PREX2,NFIA,CTNNA2,CTNND2,RORA,GPM6A
1.129e-06	-13.69	system development	biological process	GO:0048731	3533	25	18204	50	TNIK,BMPR1B,CLU,PTPRZ1,HIF3A,CTNNA2,SLC1A2,GPM6A,PRKG1,SOX5,ERBB4,PARD3,PREX2,SLC1A3,NTM,NFIA,LRIG1,MSI2,FGFR3,RFX4,CTNND2,ATP1A2,TRPS1,RORA,LSAMP
1.377e-06	-13.50	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	12	16828	49	SLC1A2,RYR3,LSAMP,GPC5,MAML2,PARD3,ERBB4,NKAIN3,PREX2,SOX5,ATP1A2,FBXL7
1.623e-06	-13.33	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	8	19454	50	ABLIM1,NHSL1,CTNNA2,DTNA,PARD3,MACF1,TNIK,SORBS1
1.873e-06	-13.19	mouth	COSMIC cancer mutations	mouth	9004	42	16828	49	TRPS1,PARD3B,ATP1A2,GPM6A,ACSS1,CDH20,MACF1,PREX2,ZBTB20,NPAS3,PARD3,HIF3A,NTM,ABLIM1,DTNA,RYR3,LSAMP,MAML2,SFXN5,PITPNC1,SLC1A3,FBXL7,NHSL1,SLC4A4,ATP13A4,FGFR3,TRPM3,CTNND2,SOX5,PRKG1,RFX4,ZNRF3,ERBB4,CST3,SORBS1,PTPRZ1,SLC1A2,RORA,LRIG1,TNIK,GPC5,CLU
2.220e-06	-13.02	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	28	16828	49	TNIK,LRIG1,PTPRZ1,SORBS1,RFX4,PRKG1,SOX5,CTNND2,TRPM3,FGFR3,ATP13A4,SLC4A4,NHSL1,FBXL7,PTGDS,RYR3,NTM,HIF3A,PARD3,ZBTB20,NFIA,PREX2,MACF1,CDH20,ACSS1,GPM6A,PARD3B,TRPS1
2.259e-06	-13.00	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	22	16828	49	FBXL7,GPM6A,TRPS1,SLC1A3,PARD3B,CTNND2,SOX5,PREX2,PRKG1,RFX4,NKAIN3,HIF3A,ZNRF3,ERBB4,PARD3,MAML2,SFXN5,GPC5,LSAMP,RYR3,SLC1A2,LRIG1
2.341e-06	-12.96	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	27	16828	49	HIF3A,PARD3,NPAS3,PITPNC1,MAML2,RYR3,ACSS1,GPM6A,ATP1A2,PARD3B,TRPS1,NFIA,PREX2,MACF1,PTPRZ1,ERBB4,ZNRF3,TNIK,GLIS3,SLC1A2,NHSL1,FBXL7,RFX4,PRKG1,CTNND2,FGFR3,SLC4A4
3.516e-06	-12.56	tibia	COSMIC cancer mutations	tibia	836	12	16828	49	ABLIM1,TNIK,LSAMP,ACSS1,GPM6A,NKAIN3,MACF1,FGFR3,PRKG1,PREX2,TRPM3,CTNND2
3.650e-06	-12.52	MAPT (microtubule associated protein tau)	protein interactions	4137	948	12	19454	50	NTM,CTNND2,CLU,SLC1A2,CTNNA2,TNIK,ATP1A2,ABLIM1,SLC1A3,GPM6A,LSAMP,SORBS1
3.755e-06	-12.49	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	49	RYR3,LSAMP,MAML2,PARD3,ZBTB20,NTM,HIF3A,PREX2,NFIA,GPM6A,TNIK,GLIS3,SLC1A2,RORA,GPC5,BMPR1B,ERBB4,PTPRZ1,NKAIN3,SLC4A4,ATP13A4,PRKG1,SOX5,CTNND2,SLC1A3,FBXL7
3.755e-06	-12.49	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	49	GPM6A,PREX2,NFIA,PARD3,ZBTB20,NTM,HIF3A,LSAMP,RYR3,MAML2,SLC1A3,FBXL7,NKAIN3,SLC4A4,ATP13A4,PRKG1,SOX5,CTNND2,BMPR1B,ERBB4,PTPRZ1,TNIK,GLIS3,SLC1A2,RORA,GPC5
4.679e-06	-12.27	cell junction	cellular component	GO:0030054	2224	18	19108	49	SLC1A2,GPM6A,FGFR3,CTNNA2,DTNA,SPARCL1,PARD3,TNIK,ERBB4,ATP1A2,CDH20,PARD3B,CLU,SORBS1,PTPRZ1,SLC1A3,CTNND2,NFIA
4.871e-06	-12.23	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	27	16828	49	MACF1,CDH20,PREX2,SPARCL1,TRPS1,ACSS1,ATP1A2,GPM6A,LSAMP,RYR3,MAML2,PARD3,DTNA,FGFR3,NKAIN3,ATP13A4,PRKG1,CTNND2,SOX5,SLC1A3,FBXL7,TNIK,RORA,SLC1A2,GPC5,CLU,ERBB4
6.057e-06	-12.01	neuron projection morphogenesis	biological process	GO:0048812	486	9	18204	50	CTNND2,PTPRZ1,PREX2,GPM6A,PRKG1,TNIK,CTNNA2,PARD3,BMPR1B
6.578e-06	-11.93	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	9	18204	50	PRKG1,TNIK,CTNNA2,BMPR1B,PARD3,CTNND2,GPM6A,PREX2,PTPRZ1
7.138e-06	-11.85	cell projection morphogenesis	biological process	GO:0048858	496	9	18204	50	CTNND2,PREX2,GPM6A,PTPRZ1,PRKG1,PARD3,BMPR1B,TNIK,CTNNA2
7.143e-06	-11.85	Par3/HAL_N	interpro domains	IPR021922	2	2	18521	50	PARD3B,PARD3
7.388e-06	-11.82	pharynx	COSMIC cancer mutations	pharynx	2696	21	16828	49	NPAS3,PTPRZ1,SORBS1,DTNA,SLC1A2,RYR3,CLU,PITPNC1,GPC5,SFXN5,PARD3B,NHSL1,ATP1A2,FGFR3,MACF1,SLC4A4,ATP13A4,RFX4,NFIA,PREX2,CTNND2
7.657e-06	-11.78	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	26	16828	49	PTPRZ1,ERBB4,ZNRF3,SLC1A2,TNIK,GLIS3,FBXL7,CTNND2,RFX4,PRKG1,SLC4A4,FGFR3,HIF3A,PARD3,NPAS3,MAML2,PITPNC1,RYR3,GPM6A,ATP1A2,ACSS1,TRPS1,PARD3B,PREX2,NFIA,MACF1
7.694e-06	-11.78	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	26	16828	49	TRPS1,PARD3B,GPM6A,ATP1A2,ACSS1,MACF1,NFIA,PREX2,PARD3,NPAS3,HIF3A,RYR3,MAML2,PITPNC1,FBXL7,SLC4A4,FGFR3,CTNND2,RFX4,PRKG1,ERBB4,ZNRF3,PTPRZ1,SLC1A2,GLIS3,TNIK
7.737e-06	-11.77	Par3_HAL_N_term	pfam domains	PF12053	2	2	17795	50	PARD3,PARD3B
8.240e-06	-11.71	adherens junction	cellular component	GO:0005912	188	6	19108	49	CTNND2,CTNNA2,CDH20,PARD3B,SORBS1,PARD3
1.002e-05	-11.51	cerebellum	COSMIC cancer mutations	cerebellum	769	11	16828	49	RYR3,MAML2,GPC5,PARD3,ERBB4,NPAS3,ABLIM1,PTPRZ1,CTNND2,PRKG1,PARD3B
1.311e-05	-11.24	anatomical structure development	biological process	GO:0048856	5207	29	18204	50	TNIK,BMPR1B,CLU,PTPRZ1,HIF3A,CTNNA2,SLC1A2,GPM6A,PRKG1,SOX5,ERBB4,PARD3,SLC1A3,PREX2,NTM,CDH20,NFIA,LRIG1,SPARCL1,FGFR3,MSI2,CTNND2,RFX4,ABLIM1,ZNRF3,TRPS1,ATP1A2,RORA,LSAMP
1.324e-05	-11.23	multicellular organismal process	biological process	GO:0032501	6177	32	18204	50	BMPR1B,TNIK,HIF3A,PTPRZ1,CLU,CTNNA2,RYR3,GPM6A,SLC1A2,DTNA,SLC4A4,PARD3,ERBB4,SOX5,PRKG1,NTM,CDH20,PREX2,SLC1A3,MSI2,FGFR3,LRIG1,NFIA,PTGDS,RORA,LSAMP,ATP1A2,TRPS1,ZNRF3,RFX4,ABLIM1,CTNND2
1.509e-05	-11.10	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	10	16828	49	ABLIM1,PTPRZ1,PARD3,ERBB4,PARD3B,NPAS3,CTNND2,MAML2,PRKG1,RYR3
1.529e-05	-11.09	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	10	16828	49	RYR3,PRKG1,MAML2,CTNND2,PARD3,ERBB4,NPAS3,PARD3B,PTPRZ1,ABLIM1
1.598e-05	-11.04	nodular	COSMIC cancer mutations	nodular	1515	15	16828	49	ERBB4,NPAS3,HIF3A,ABLIM1,PTPRZ1,GLIS3,SPARCL1,ATP1A2,ATP13A4,CDH20,SLC4A4,FGFR3,MACF1,CTNND2,PREX2
1.668e-05	-11.00	neuron development	biological process	GO:0048666	859	11	18204	50	PRKG1,TNIK,CTNNA2,BMPR1B,PARD3,CTNND2,SLC1A3,PTPRZ1,PREX2,GPM6A,NTM
1.702e-05	-10.98	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	15	16828	49	NKAIN3,SOX5,CTNND2,PRKG1,PREX2,SLC1A3,FBXL7,ACSS1,RORA,LSAMP,RYR3,MAML2,GPC5,ERBB4,PARD3
1.702e-05	-10.98	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	15	16828	49	RORA,RYR3,LSAMP,GPC5,MAML2,PARD3,ERBB4,NKAIN3,PREX2,PRKG1,SOX5,CTNND2,SLC1A3,ACSS1,FBXL7
1.782e-05	-10.94	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	24	16828	49	ERBB4,TNIK,SLC1A2,RORA,CLU,GPC5,FBXL7,NKAIN3,FGFR3,ATP13A4,PRKG1,SOX5,CTNND2,PARD3,RYR3,LSAMP,MAML2,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,PREX2
2.020e-05	-10.81	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	9	16828	49	GPM6A,NKAIN3,LSAMP,RYR3,PRKG1,GPC5,CTNND2,SFXN5,SOX5
2.529e-05	-10.59	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	8	18204	50	PRKG1,CTNNA2,BMPR1B,PARD3,CTNND2,SLC1A3,PTPRZ1,PREX2
2.544e-05	-10.58	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	18	16828	49	MAML2,GPC5,LSAMP,RYR3,SLC1A2,PTPRZ1,PARD3,ERBB4,CTNND2,SOX5,PRKG1,PREX2,CDH20,FGFR3,NKAIN3,FBXL7,GPM6A,SLC1A3
2.773e-05	-10.49	developmental process	biological process	GO:0032502	5716	30	18204	50	ZNRF3,CTNND2,RFX4,ABLIM1,LSAMP,RORA,TRPS1,ATP1A2,NFIA,FGFR3,MSI2,LRIG1,SPARCL1,CDH20,NTM,SLC1A3,PREX2,PRKG1,SOX5,PARD3,ERBB4,SLC1A2,NHSL1,GPM6A,CTNNA2,CLU,HIF3A,PTPRZ1,BMPR1B,TNIK
2.973e-05	-10.42	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	47	16828	49	RYR3,MSI2,NFIA,MACF1,CDH20,ACSS1,ATP1A2,GPM6A,SPARCL1,PARD3B,CLU,SLC1A2,SORBS1,ZNRF3,BMPR1B,TRPM3,SLC4A4,FBXL7,PITPNC1,SFXN5,MAML2,LSAMP,DTNA,HIF3A,ABLIM1,NTM,NPAS3,PARD3,ZBTB20,PREX2,TRPS1,GPC5,TNIK,GLIS3,RORA,LRIG1,PTPRZ1,ERBB4,PRKG1,RFX4,CTNND2,SOX5,FGFR3,NKAIN3,ATP13A4,NHSL1,SLC1A3
3.292e-05	-10.32	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	33	16828	49	NPAS3,PARD3,ZBTB20,HIF3A,NTM,ABLIM1,RYR3,PITPNC1,MAML2,SFXN5,PARD3B,TRPS1,ACSS1,GPM6A,MACF1,CDH20,PREX2,ERBB4,SORBS1,SLC1A2,RORA,GPC5,CLU,SLC1A3,FBXL7,NHSL1,FGFR3,SLC4A4,PRKG1,RFX4,CTNND2,TRPM3,SOX5
3.970e-05	-10.13	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	23	16828	49	BMPR1B,ERBB4,ZNRF3,PTPRZ1,TNIK,CLU,GPC5,SLC1A3,FBXL7,SLC4A4,PRKG1,TRPM3,CTNND2,PARD3,NPAS3,DTNA,MSI2,LSAMP,RYR3,PITPNC1,PARD3B,MACF1,PREX2
3.970e-05	-10.13	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	23	16828	49	GPC5,CLU,TNIK,PTPRZ1,ZNRF3,BMPR1B,ERBB4,PRKG1,CTNND2,TRPM3,SLC4A4,FBXL7,SLC1A3,PITPNC1,MSI2,LSAMP,RYR3,DTNA,PARD3,NPAS3,PREX2,MACF1,PARD3B
3.982e-05	-10.13	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	31	16828	49	GLIS3,RORA,SLC1A2,GPC5,CLU,ZNRF3,ERBB4,SORBS1,PTPRZ1,FGFR3,NKAIN3,PRKG1,TRPM3,CTNND2,SOX5,SLC1A3,FBXL7,NHSL1,RYR3,LSAMP,MAML2,PARD3,NPAS3,MACF1,CDH20,PREX2,NFIA,SPARCL1,PARD3B,TRPS1,GPM6A
5.020e-05	-9.90	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	35	16828	49	CLU,RORA,LRIG1,SLC1A2,PTPRZ1,CST3,ZNRF3,ERBB4,PRKG1,RFX4,CTNND2,TRPM3,SOX5,FGFR3,SLC4A4,ATP13A4,FBXL7,NHSL1,PITPNC1,SFXN5,MAML2,RYR3,LSAMP,NTM,PARD3,NPAS3,ZBTB20,NFIA,PREX2,MACF1,CDH20,ACSS1,ATP1A2,PARD3B,TRPS1
5.020e-05	-9.90	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	35	16828	49	NHSL1,FBXL7,ATP13A4,SLC4A4,FGFR3,SOX5,TRPM3,CTNND2,RFX4,PRKG1,ERBB4,ZNRF3,CST3,PTPRZ1,LRIG1,SLC1A2,RORA,CLU,TRPS1,PARD3B,ATP1A2,ACSS1,CDH20,MACF1,NFIA,PREX2,ZBTB20,PARD3,NPAS3,NTM,RYR3,LSAMP,MAML2,SFXN5,PITPNC1
5.256e-05	-9.85	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	31	SLC1A3,SLC1A2
5.256e-05	-9.85	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	31	SLC1A2,SLC1A3
5.396e-05	-9.83	scalp	COSMIC cancer mutations	scalp	2110	17	16828	49	TRPS1,ATP1A2,FGFR3,MACF1,ATP13A4,SLC4A4,NFIA,PREX2,PRKG1,SOX5,ERBB4,SORBS1,PTPRZ1,NTM,LSAMP,RORA,GPC5
5.657e-05	-9.78	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	20	16828	49	MACF1,FGFR3,NKAIN3,SLC4A4,PRKG1,PREX2,TRPM3,CTNND2,SPARCL1,TRPS1,NHSL1,TNIK,RYR3,LRIG1,CLU,PITPNC1,ZNRF3,PARD3,ERBB4,PTPRZ1
5.657e-05	-9.78	gallbladder	COSMIC cancer mutations	gallbladder	2821	20	16828	49	SPARCL1,TRPS1,NHSL1,MACF1,FGFR3,NKAIN3,SLC4A4,PRKG1,PREX2,TRPM3,CTNND2,ZNRF3,PARD3,ERBB4,PTPRZ1,TNIK,RYR3,LRIG1,PITPNC1,CLU
5.783e-05	-9.76	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	13	16828	49	ATP13A4,CDH20,MACF1,CTNND2,PREX2,SPARCL1,ATP1A2,GLIS3,NPAS3,ERBB4,HIF3A,ABLIM1,PTPRZ1
6.432e-05	-9.65	central nervous system development	biological process	GO:0007417	995	11	18204	50	RFX4,CLU,SLC1A2,ATP1A2,PTPRZ1,RORA,PRKG1,CTNNA2,MSI2,BMPR1B,ERBB4
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A3,SLC1A2
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A3,SLC1A2
7.355e-05	-9.52	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	50	SLC1A3,SLC1A2
7.355e-05	-9.52	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	50	SLC1A3,SLC1A2
7.513e-05	-9.50	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	50	SLC1A3,ATP1A2,SLC1A2
7.798e-05	-9.46	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	30	16828	49	MAML2,LSAMP,RYR3,DTNA,NTM,PARD3,NPAS3,MACF1,CDH20,ATP1A2,GPM6A,PARD3B,TRPS1,GPC5,CLU,LRIG1,SORBS1,PTPRZ1,CST3,ZNRF3,ERBB4,PRKG1,CTNND2,TRPM3,SOX5,NKAIN3,SLC4A4,ATP13A4,FBXL7,SLC1A3
7.798e-05	-9.46	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	30	16828	49	NPAS3,PARD3,DTNA,NTM,LSAMP,RYR3,MAML2,PARD3B,TRPS1,ATP1A2,GPM6A,MACF1,CDH20,ZNRF3,ERBB4,SORBS1,PTPRZ1,CST3,LRIG1,GPC5,CLU,SLC1A3,FBXL7,NKAIN3,SLC4A4,ATP13A4,PRKG1,TRPM3,CTNND2,SOX5
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	NTM,GPM6A,LSAMP
8.772e-05	-9.34	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	17	16828	49	FBXL7,GPM6A,SLC1A3,CTNND2,SOX5,PRKG1,PREX2,CDH20,NKAIN3,PTPRZ1,ERBB4,PARD3,MAML2,GPC5,LSAMP,RYR3,SLC1A2
8.772e-05	-9.34	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	17	16828	49	CDH20,NKAIN3,SOX5,CTNND2,PREX2,PRKG1,SLC1A3,GPM6A,FBXL7,SLC1A2,LSAMP,RYR3,MAML2,GPC5,PARD3,ERBB4,PTPRZ1
9.059e-05	-9.31	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	50	SLC1A2,SLC4A4,ATP1A2,SLC1A3
9.059e-05	-9.31	vascular transport	biological process	GO:0010232	86	4	18204	50	SLC1A2,ATP1A2,SLC1A3,SLC4A4
9.079e-05	-9.31	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	48	16828	49	RYR3,MSI2,PARD3B,GPM6A,ATP1A2,ACSS1,CDH20,MACF1,NFIA,BMPR1B,ZNRF3,SORBS1,SLC1A2,CLU,FBXL7,SLC4A4,TRPM3,ZBTB20,NPAS3,PARD3,ABLIM1,NTM,HIF3A,DTNA,LSAMP,SFXN5,MAML2,PITPNC1,PTGDS,TRPS1,PREX2,ERBB4,CST3,PTPRZ1,RORA,LRIG1,TNIK,GLIS3,GPC5,SLC1A3,NHSL1,ATP13A4,NKAIN3,FGFR3,SOX5,CTNND2,RFX4,PRKG1
9.194e-05	-9.29	cell junction organization	biological process	GO:0034330	532	8	18204	50	SORBS1,CTNND2,CDH20,GPM6A,NFIA,ERBB4,PARD3,SPARCL1
9.850e-05	-9.23	neuron projection development	biological process	GO:0031175	693	9	18204	50	BMPR1B,PARD3,TNIK,CTNNA2,PRKG1,PTPRZ1,GPM6A,PREX2,CTNND2
1.023e-04	-9.19	bone	COSMIC cancer mutations	bone	8157	37	16828	49	MACF1,PREX2,PARD3B,SPARCL1,TRPS1,ACSS1,GPM6A,ATP1A2,LSAMP,RYR3,PTGDS,MAML2,SFXN5,PARD3,NPAS3,ZBTB20,DTNA,ABLIM1,HIF3A,NKAIN3,FGFR3,ATP13A4,SLC4A4,PRKG1,SOX5,CTNND2,TRPM3,SLC1A3,TNIK,GLIS3,LRIG1,RORA,GPC5,ERBB4,PTPRZ1,SORBS1,CST3
1.101e-04	-9.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	50	SLC1A2,SLC1A3
1.101e-04	-9.11	D-amino acid transport	biological process	GO:0042940	6	2	18204	50	SLC1A3,SLC1A2
1.186e-04	-9.04	Salivary secretion	KEGG pathways	hsa04970	90	4	7161	21	PRKG1,ATP1A2,RYR3,CST3
1.186e-04	-9.04	Salivary secretion	KEGG pathways	ko04970	90	4	7161	21	ATP1A2,PRKG1,RYR3,CST3
1.378e-04	-8.89	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	9	18094	48	GPM6A,ATP1A2,ATP13A4,TRPM3,SLC4A4,SLC1A3,SFXN5,RYR3,SLC1A2
1.427e-04	-8.85	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	5	18204	50	SLC4A4,RORA,PRKG1,SORBS1,ZBTB20
1.469e-04	-8.83	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	4	19454	50	CLU,SORBS1,ABLIM1,SPARCL1
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A2,SLC1A3
1.534e-04	-8.78	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	7	18094	48	GPM6A,ATP1A2,TRPM3,SLC4A4,SLC1A3,SLC1A2,RYR3
1.583e-04	-8.75	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	13	16828	49	ATP1A2,NHSL1,CTNND2,PREX2,NFIA,RFX4,ATP13A4,SLC4A4,FGFR3,SFXN5,PITPNC1,CLU,SLC1A2
1.583e-04	-8.75	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	13	16828	49	PITPNC1,CLU,SFXN5,SLC1A2,NFIA,PREX2,RFX4,CTNND2,FGFR3,SLC4A4,ATP13A4,ATP1A2,NHSL1
1.610e-04	-8.73	SDF	pfam domains	PF00375	7	2	17795	50	SLC1A3,SLC1A2
1.628e-04	-8.72	humerus	COSMIC cancer mutations	humerus	546	8	16828	49	NKAIN3,SOX5,SFXN5,PRKG1,GPC5,PARD3B,GPM6A,HIF3A
1.662e-04	-8.70	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	50	SLC1A3,RYR3,SLC1A2
1.773e-04	-8.64	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	24	16828	49	ATP13A4,FGFR3,SOX5,TRPM3,CTNND2,PRKG1,ERBB4,ZNRF3,PTPRZ1,LRIG1,TNIK,GLIS3,GPC5,TRPS1,SPARCL1,ATP1A2,ACSS1,MACF1,NFIA,PARD3,HIF3A,DTNA,LSAMP,RYR3
1.794e-04	-8.63	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	43	SLC1A2,SLC1A3
1.841e-04	-8.60	beta-catenin binding	molecular function	GO:0008013	107	4	18094	48	CTNNA2,CDH20,RORA,CTNND2
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	NKAIN3,LSAMP,CTNND2,GPM6A
2.276e-04	-8.39	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	8	18094	48	GPM6A,ATP1A2,ATP13A4,TRPM3,SLC4A4,SLC1A3,RYR3,SLC1A2
2.282e-04	-8.39	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	6	16828	49	SFXN5,SOX5,GPC5,PRKG1,NKAIN3,GPM6A
2.300e-04	-8.38	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	45	16828	49	ZNRF3,BMPR1B,ERBB4,CST3,SORBS1,PTPRZ1,SLC1A2,RORA,LRIG1,GLIS3,TNIK,GPC5,SLC1A3,FBXL7,NHSL1,SLC4A4,ATP13A4,FGFR3,CTNND2,TRPM3,SOX5,PRKG1,RFX4,ZBTB20,PARD3,NPAS3,HIF3A,NTM,ABLIM1,DTNA,RYR3,LSAMP,MAML2,SFXN5,PITPNC1,TRPS1,SPARCL1,PARD3B,ATP1A2,GPM6A,ACSS1,CDH20,MACF1,NFIA,PREX2
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	NTM,LSAMP
2.328e-04	-8.37	cervix	COSMIC cancer mutations	cervix	11793	45	16828	49	PTPRZ1,CST3,ERBB4,GPC5,GLIS3,TNIK,RORA,LRIG1,NHSL1,SLC1A3,RFX4,PRKG1,SOX5,CTNND2,FGFR3,ATP13A4,DTNA,ABLIM1,NTM,HIF3A,NPAS3,PARD3,ZBTB20,PITPNC1,MAML2,SFXN5,LSAMP,TRPS1,PREX2,SORBS1,BMPR1B,ZNRF3,SLC1A2,FBXL7,TRPM3,SLC4A4,RYR3,ACSS1,GPM6A,ATP1A2,PARD3B,SPARCL1,NFIA,MACF1,CDH20
2.357e-04	-8.35	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	11	18204	50	RFX4,ABLIM1,CTNND2,GPM6A,CTNNA2,PREX2,PTPRZ1,PRKG1,TNIK,BMPR1B,PARD3
2.526e-04	-8.28	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	43	SLC1A3,SLC1A2
2.526e-04	-8.28	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	43	SLC1A3,SLC1A2
2.601e-04	-8.25	EDTRNSPORT	prints domains	PR00173	7	2	5227	19	SLC1A3,SLC1A2
2.601e-04	-8.25	dendrite development	biological process	GO:0016358	113	4	18204	50	PREX2,CTNNA2,PRKG1,CTNND2
2.644e-04	-8.24	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	30	16828	49	CLU,GPC5,LRIG1,GLIS3,PTPRZ1,SORBS1,ERBB4,TRPM3,RFX4,PRKG1,ATP13A4,SLC4A4,FGFR3,SLC1A3,SFXN5,ABLIM1,HIF3A,DTNA,ZBTB20,PARD3,NFIA,PREX2,CDH20,MACF1,GPM6A,ATP1A2,ACSS1,TRPS1,PARD3B,SPARCL1
2.662e-04	-8.23	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	30	16828	49	SFXN5,ABLIM1,HIF3A,DTNA,ZBTB20,PARD3,NFIA,PREX2,CDH20,MACF1,GPM6A,ATP1A2,ACSS1,TRPS1,PARD3B,SPARCL1,CLU,GPC5,LRIG1,GLIS3,PTPRZ1,SORBS1,ERBB4,TRPM3,RFX4,PRKG1,SLC4A4,ATP13A4,FGFR3,SLC1A3
2.833e-04	-8.17	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	35	16828	49	MAML2,SFXN5,RYR3,LSAMP,ABLIM1,PARD3,PREX2,CDH20,MACF1,ATP1A2,GPM6A,ACSS1,TRPS1,GPC5,CLU,RORA,SLC1A2,LRIG1,TNIK,GLIS3,PTPRZ1,BMPR1B,ERBB4,CTNND2,TRPM3,SOX5,PRKG1,RFX4,ATP13A4,SLC4A4,FGFR3,NKAIN3,FBXL7,NHSL1,SLC1A3
2.855e-04	-8.16	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	15	16828	49	ZBTB20,NPAS3,ERBB4,BMPR1B,ZNRF3,RORA,RYR3,TNIK,MAML2,PARD3B,GPM6A,SLC4A4,MACF1,FGFR3,SOX5
2.887e-04	-8.15	larynx	COSMIC cancer mutations	larynx	1948	15	16828	49	MAML2,TNIK,RYR3,RORA,ZNRF3,ERBB4,NPAS3,BMPR1B,ZBTB20,SOX5,FGFR3,MACF1,SLC4A4,GPM6A,PARD3B
2.903e-04	-8.14	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	17	16828	49	NHSL1,SLC1A3,TRPS1,SPARCL1,PARD3B,TRPM3,NFIA,PREX2,CDH20,MACF1,FGFR3,SORBS1,ZNRF3,NPAS3,PARD3,CLU,RYR3
2.903e-04	-8.14	alveolar	COSMIC cancer mutations	alveolar	2414	17	16828	49	SORBS1,ZNRF3,NPAS3,PARD3,CLU,RYR3,NHSL1,SLC1A3,TRPS1,SPARCL1,PARD3B,TRPM3,NFIA,PREX2,CDH20,FGFR3,MACF1
3.003e-04	-8.11	monoatomic ion transmembrane transport	biological process	GO:0034220	804	9	18204	50	TRPM3,SFXN5,SLC4A4,RYR3,SLC1A3,GPM6A,ATP1A2,ATP13A4,SLC1A2
3.121e-04	-8.07	cell-cell junction	cellular component	GO:0005911	513	7	19108	49	CTNNA2,CTNND2,PARD3B,SORBS1,ATP1A2,CDH20,PARD3
3.155e-04	-8.06	plasma membrane region	cellular component	GO:0098590	1278	11	19108	49	SLC1A3,PARD3B,MACF1,SORBS1,ERBB4,ATP1A2,PARD3,TNIK,GPM6A,SLC4A4,SLC1A2
3.162e-04	-8.06	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	4	19454	50	DTNA,MACF1,PARD3,ABLIM1
3.281e-04	-8.02	establishment of centrosome localization	biological process	GO:0051660	10	2	18204	50	PARD3,PARD3B
3.281e-04	-8.02	cellular response to cocaine	biological process	GO:0071314	10	2	18204	50	SLC1A3,SLC1A2
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	RYR3,SLC1A2,SOX5,PREX2
3.355e-04	-8.00	cell projection organization	biological process	GO:0030030	1200	11	18204	50	CTNNA2,GPM6A,RFX4,ABLIM1,CTNND2,TNIK,BMPR1B,PARD3,PRKG1,PREX2,PTPRZ1
3.355e-04	-8.00	arm	COSMIC cancer mutations	arm	1331	12	16828	49	ZBTB20,ERBB4,NPAS3,NTM,SORBS1,SLC4A4,MACF1,FGFR3,TRPM3,TRPS1,PARD3B,ATP1A2
3.918e-04	-7.84	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	31	16828	49	FBXL7,PRKG1,SOX5,CTNND2,TRPM3,FGFR3,ATP13A4,SLC4A4,PTPRZ1,SORBS1,ERBB4,BMPR1B,GPC5,TNIK,GLIS3,GPM6A,ATP1A2,PARD3B,SPARCL1,TRPS1,PREX2,MACF1,ABLIM1,HIF3A,PARD3,NPAS3,ZBTB20,PITPNC1,MAML2,SFXN5,RYR3
3.988e-04	-7.83	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	4	19454	50	DTNA,ABLIM1,ERBB4,PARD3
4.003e-04	-7.82	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	50	SLC1A2,SLC1A3
4.003e-04	-7.82	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	50	SLC1A3,SLC1A2
4.146e-04	-7.79	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	50	BMPR1B,SOX5,TRPS1
4.301e-04	-7.75	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	50	TNIK,SLC1A3,PARD3,MACF1,MSI2,DTNA,ERBB4,ABLIM1
4.404e-04	-7.73	Ig_I-set	interpro domains	IPR013098	132	4	18521	50	NTM,LRIG1,LSAMP,FGFR3
4.439e-04	-7.72	NAKATPASE	prints domains	PR00121	9	2	5227	19	ATP13A4,ATP1A2
4.673e-04	-7.67	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	15	16828	49	PTPRZ1,ABLIM1,PARD3,ERBB4,ZNRF3,GPC5,RORA,LSAMP,MSI2,GPM6A,TRPS1,PREX2,TRPM3,MACF1,FGFR3
4.724e-04	-7.66	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	24	16828	49	RYR3,ABLIM1,HIF3A,DTNA,PARD3,PREX2,MACF1,GPM6A,ATP1A2,ACSS1,TRPS1,CLU,GLIS3,PTPRZ1,ERBB4,ZNRF3,SOX5,TRPM3,CTNND2,RFX4,PRKG1,FGFR3,NHSL1,SLC1A3
4.724e-04	-7.66	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	24	16828	49	PARD3,DTNA,ABLIM1,HIF3A,RYR3,TRPS1,ACSS1,GPM6A,ATP1A2,MACF1,PREX2,ERBB4,ZNRF3,PTPRZ1,GLIS3,CLU,SLC1A3,NHSL1,FGFR3,RFX4,PRKG1,SOX5,CTNND2,TRPM3
4.778e-04	-7.65	sarcolemma	cellular component	GO:0042383	142	4	19108	49	PRKG1,ATP1A2,DTNA,RYR3
4.895e-04	-7.62	trunk	COSMIC cancer mutations	trunk	3554	21	16828	49	SLC1A3,TRPS1,SPARCL1,ATP1A2,ATP13A4,CDH20,MACF1,FGFR3,SOX5,CTNND2,PREX2,ERBB4,NPAS3,PARD3,ABLIM1,HIF3A,PTPRZ1,LSAMP,RYR3,GLIS3,MAML2
5.115e-04	-7.58	I-set	pfam domains	PF07679	132	4	17795	50	LRIG1,FGFR3,NTM,LSAMP
5.217e-04	-7.56	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	8	16828	49	ACSS1,ABLIM1,TNIK,FGFR3,MACF1,PRKG1,PREX2,TRPM3
5.776e-04	-7.46	PLXNA4 (plexin A4)	protein interactions	91584	14	2	19454	50	GPM6A,CLU
6.086e-04	-7.40	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	4	19454	50	MACF1,TNIK,PRKG1,CLU
6.089e-04	-7.40	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	40	16828	49	GPM6A,ATP1A2,TRPS1,PARD3B,SPARCL1,PREX2,NFIA,CDH20,MACF1,NTM,ABLIM1,HIF3A,DTNA,NPAS3,PARD3,MAML2,PITPNC1,RYR3,MSI2,FBXL7,SOX5,TRPM3,CTNND2,RFX4,PRKG1,SLC4A4,ATP13A4,NKAIN3,FGFR3,CST3,PTPRZ1,SORBS1,BMPR1B,ERBB4,ZNRF3,CLU,GPC5,LRIG1,RORA,TNIK
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A3,SLC1A2
6.176e-04	-7.39	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	40	16828	49	MAML2,PITPNC1,MSI2,RYR3,HIF3A,NTM,ABLIM1,DTNA,NPAS3,PARD3,PREX2,NFIA,CDH20,MACF1,ATP1A2,GPM6A,TRPS1,SPARCL1,PARD3B,GPC5,CLU,RORA,LRIG1,TNIK,CST3,SORBS1,PTPRZ1,ZNRF3,BMPR1B,ERBB4,CTNND2,TRPM3,SOX5,PRKG1,RFX4,ATP13A4,SLC4A4,FGFR3,NKAIN3,FBXL7
6.556e-04	-7.33	Ig_3	pfam domains	PF13927	141	4	17795	50	LSAMP,LRIG1,FGFR3,NTM
6.588e-04	-7.33	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	50	ATP1A2,SLC4A4
6.654e-04	-7.32	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	2	19454	50	PARD3,TNIK
6.985e-04	-7.27	cell development	biological process	GO:0048468	2236	15	18204	50	CLU,PTPRZ1,SLC1A3,PREX2,NTM,PRKG1,TNIK,ERBB4,PARD3,BMPR1B,CTNND2,GPM6A,RORA,CTNNA2,MSI2
7.080e-04	-7.25	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	4	16828	49	FGFR3,PARD3,GPC5,PRKG1
7.170e-04	-7.24	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	41	16828	49	PITPNC1,SFXN5,RYR3,LSAMP,DTNA,NTM,ABLIM1,HIF3A,PARD3,NPAS3,ZBTB20,PREX2,NFIA,MACF1,CDH20,GPM6A,ATP1A2,PARD3B,TRPS1,GPC5,GLIS3,TNIK,LRIG1,SLC1A2,RORA,PTPRZ1,SORBS1,BMPR1B,ERBB4,ZNRF3,RFX4,PRKG1,SOX5,CTNND2,TRPM3,NKAIN3,FGFR3,ATP13A4,SLC4A4,FBXL7,SLC1A3
7.170e-04	-7.24	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	41	16828	49	PARD3B,TRPS1,GPM6A,ATP1A2,MACF1,CDH20,PREX2,NFIA,NPAS3,PARD3,ZBTB20,DTNA,NTM,ABLIM1,HIF3A,RYR3,LSAMP,PITPNC1,SFXN5,SLC1A3,FBXL7,NKAIN3,FGFR3,SLC4A4,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,TRPM3,BMPR1B,ERBB4,ZNRF3,PTPRZ1,SORBS1,GLIS3,TNIK,LRIG1,RORA,SLC1A2,GPC5
7.220e-04	-7.23	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	50	CTNNA2,PREX2,CTNND2
7.686e-04	-7.17	adenoma	COSMIC cancer mutations	adenoma	2873	18	16828	49	RYR3,GPC5,ZBTB20,PARD3,ERBB4,NPAS3,BMPR1B,HIF3A,PTPRZ1,CDH20,FGFR3,MACF1,SOX5,CTNND2,TRPM3,PRKG1,GPM6A,ACSS1
7.721e-04	-7.17	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	5	18094	48	SLC1A3,SLC1A2,ATP1A2,SLC4A4,ATP13A4
7.916e-04	-7.14	face	COSMIC cancer mutations	face	2139	15	16828	49	FGFR3,MACF1,PREX2,TRPM3,TRPS1,GPM6A,RORA,LSAMP,MSI2,GPC5,ERBB4,PARD3,ZNRF3,PTPRZ1,ABLIM1
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	ATP1A2,SLC4A4,SLC1A3,SLC1A2
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	ZBTB20,LSAMP
8.632e-04	-7.05	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	7	18094	48	SLC4A4,TRPM3,SLC1A2,RYR3,SLC1A3,ATP1A2,GPM6A
8.657e-04	-7.05	asymmetric cell division	biological process	GO:0008356	16	2	18204	50	SOX5,PARD3
8.890e-04	-7.03	cellular response to endogenous stimulus	biological process	GO:0071495	1135	10	18204	50	SLC1A2,SORBS1,ATP1A2,SLC1A3,NFIA,RYR3,SOX5,FGFR3,ERBB4,BMPR1B
8.898e-04	-7.02	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	33	16828	49	TRPM3,CTNND2,SOX5,PRKG1,ATP13A4,SLC4A4,FGFR3,NKAIN3,SLC1A3,RORA,LRIG1,TNIK,GLIS3,CST3,SORBS1,PTPRZ1,ERBB4,PREX2,MACF1,ATP1A2,ACSS1,TRPS1,SPARCL1,PARD3B,MAML2,PTGDS,RYR3,HIF3A,ABLIM1,DTNA,ZBTB20,NPAS3,PARD3
8.927e-04	-7.02	vascular process in circulatory system	biological process	GO:0003018	273	5	18204	50	SLC4A4,SLC1A3,ATP1A2,PRKG1,SLC1A2
9.003e-04	-7.01	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	7	19454	50	PARD3,TNIK,ABLIM1,FGFR3,DTNA,NHSL1,CLU
9.444e-04	-6.96	cell adhesion	biological process	GO:0007155	942	9	18204	50	PARD3,SPARCL1,CTNNA2,SORBS1,CTNND2,NTM,CDH20,LSAMP,PARD3B
9.648e-04	-6.94	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	2	19454	50	PARD3,FGFR3
9.763e-04	-6.93	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	5	16828	49	PREX2,SOX5,FGFR3,RYR3,SLC1A2
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	GPM6A,NTM,LSAMP
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A2,SLC1A3
1.030e-03	-6.88	FLOT1 (flotillin 1)	protein interactions	10211	453	6	19454	50	PARD3,MACF1,ABLIM1,SORBS1,DTNA,SOX5
1.043e-03	-6.87	synapse	cellular component	GO:0045202	1473	11	19108	49	SLC1A2,GPM6A,DTNA,TNIK,SPARCL1,ATP1A2,ERBB4,CLU,PTPRZ1,SLC1A3,CTNND2
1.059e-03	-6.85	regulation of cartilage development	biological process	GO:0061035	73	3	18204	50	TRPS1,BMPR1B,SOX5
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP1A2,ATP13A4
1.066e-03	-6.84	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	7	16828	49	RYR3,SLC4A4,TRPS1,ERBB4,FBXL7,CTNND2,PRKG1
1.082e-03	-6.83	cell junction assembly	biological process	GO:0034329	285	5	18204	50	SORBS1,PARD3,ERBB4,CDH20,GPM6A
1.089e-03	-6.82	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	7	16828	49	RYR3,SLC4A4,CTNND2,PRKG1,TRPS1,ERBB4,FBXL7
1.096e-03	-6.82	transporter activity	molecular function	GO:0005215	1211	10	18094	48	SLC4A4,PITPNC1,TRPM3,RYR3,SLC1A2,SLC1A3,SFXN5,ATP13A4,ATP1A2,GPM6A
1.100e-03	-6.81	positive regulation of circadian rhythm	biological process	GO:0042753	18	2	18204	50	RORA,PRKG1
1.112e-03	-6.80	monoatomic ion transport	biological process	GO:0006811	964	9	18204	50	ATP1A2,GPM6A,SLC1A3,ATP13A4,SLC1A2,TRPM3,SLC4A4,SFXN5,RYR3
1.113e-03	-6.80	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	11	16828	49	ZBTB20,TRPS1,PARD3B,ERBB4,NPAS3,NTM,ATP1A2,SORBS1,SLC4A4,MACF1,TRPM3
1.138e-03	-6.78	Adherens junction	KEGG pathways	ko04520	72	3	7161	21	SORBS1,CTNNA2,PARD3
1.138e-03	-6.78	Adherens junction	KEGG pathways	hsa04520	72	3	7161	21	CTNNA2,SORBS1,PARD3
1.150e-03	-6.77	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	50	ATP1A2,ATP13A4
1.154e-03	-6.76	testis	COSMIC cancer mutations	testis	733	8	16828	49	MACF1,FGFR3,TNIK,PRKG1,PREX2,TRPS1,BMPR1B,ERBB4
1.158e-03	-6.76	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	10	16828	49	FGFR3,MACF1,ATP13A4,SLC4A4,PREX2,PRKG1,CTNND2,ERBB4,SORBS1,NTM
1.172e-03	-6.75	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	5	19454	50	TNIK,ABLIM1,PARD3,MACF1,DTNA
1.186e-03	-6.74	PAS_fold	interpro domains	IPR013767	19	2	18521	50	HIF3A,NPAS3
1.194e-03	-6.73	PDZD2 (PDZ domain containing 2)	protein interactions	23037	20	2	19454	50	CST3,CTNND2
1.194e-03	-6.73	PON1 (paraoxonase 1)	protein interactions	5444	20	2	19454	50	SFXN5,CLU
1.226e-03	-6.70	GSC (goosecoid homeobox)	protein interactions	145258	82	3	19454	50	SOX5,TRPS1,NFIA
1.227e-03	-6.70	cartilage condensation	biological process	GO:0001502	19	2	18204	50	SOX5,BMPR1B
1.235e-03	-6.70	response to endogenous stimulus	biological process	GO:0009719	1402	11	18204	50	NFIA,RYR3,PTGDS,FGFR3,SLC1A2,SORBS1,ATP1A2,ERBB4,SOX5,BMPR1B,SLC1A3
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC4A4,SLC1A2,SLC1A3
1.283e-03	-6.66	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	3	18204	50	SORBS1,ZBTB20,SLC4A4
1.283e-03	-6.66	PAS	pfam domains	PF00989	19	2	17795	50	NPAS3,HIF3A
1.290e-03	-6.65	cartilage development	biological process	GO:0051216	173	4	18204	50	NFIA,SOX5,BMPR1B,FGFR3
1.293e-03	-6.65	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	3	18094	48	FGFR3,BMPR1B,ERBB4
1.314e-03	-6.63	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	8	16828	49	TRPS1,SLC1A3,PARD3,DTNA,ACSS1,CTNND2,SOX5,PRKG1
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	SORBS1,MACF1
1.361e-03	-6.60	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	50	SLC1A3,SLC1A2
1.361e-03	-6.60	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	50	BMPR1B,SOX5
1.502e-03	-6.50	positive regulation of purine nucleotide catabolic process	biological process	GO:0033123	21	2	18204	50	ZBTB20,SLC4A4
1.502e-03	-6.50	positive regulation of nucleotide catabolic process	biological process	GO:0030813	21	2	18204	50	SLC4A4,ZBTB20
1.502e-03	-6.50	positive regulation of glycolytic process	biological process	GO:0045821	21	2	18204	50	ZBTB20,SLC4A4
1.502e-03	-6.50	cell aggregation	biological process	GO:0098743	21	2	18204	50	SOX5,BMPR1B
1.548e-03	-6.47	SFN (stratifin)	protein interactions	2810	671	7	19454	50	MACF1,PARD3,NFIA,TNIK,SORBS1,ABLIM1,PARD3B
1.560e-03	-6.46	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	22	16828	49	PARD3B,SPARCL1,TRPS1,SLC1A3,NHSL1,MACF1,FGFR3,CDH20,NFIA,PREX2,TRPM3,CTNND2,NPAS3,PARD3,ZNRF3,PTPRZ1,SORBS1,GLIS3,RORA,RYR3,CLU,MAML2
1.636e-03	-6.42	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	32	16828	49	GPM6A,ACSS1,PARD3B,SPARCL1,PREX2,CDH20,MACF1,ABLIM1,PARD3,SFXN5,MAML2,RYR3,LSAMP,NHSL1,FBXL7,SLC1A3,SOX5,CTNND2,RFX4,PRKG1,ATP13A4,NKAIN3,PTPRZ1,BMPR1B,ERBB4,CLU,GPC5,LRIG1,SLC1A2,RORA,GLIS3,TNIK
1.637e-03	-6.41	Cation_ATPase_N	smart domains	SM00831	16	2	9717	37	ATP1A2,ATP13A4
1.644e-03	-6.41	chondrocyte differentiation	biological process	GO:0002062	85	3	18204	50	SOX5,BMPR1B,FGFR3
1.649e-03	-6.41	negative regulation of muscle contraction	biological process	GO:0045932	22	2	18204	50	PRKG1,ATP1A2
1.649e-03	-6.41	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	50	SLC1A3,ATP1A2
1.664e-03	-6.40	monoatomic cation transmembrane transport	biological process	GO:0098655	636	7	18204	50	ATP13A4,GPM6A,ATP1A2,SLC1A3,RYR3,SLC4A4,TRPM3
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A2,SLC1A3
1.688e-03	-6.38	forearm	COSMIC cancer mutations	forearm	81	3	16828	49	FGFR3,ERBB4,PREX2
1.689e-03	-6.38	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	12	16828	49	TRPS1,ATP1A2,MACF1,FGFR3,SLC4A4,ATP13A4,PRKG1,SOX5,PTPRZ1,RORA,LSAMP,GPC5
1.748e-03	-6.35	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	5	16828	49	GPC5,PRKG1,RYR3,TRPS1,MACF1
1.751e-03	-6.35	neuron projection	cellular component	GO:0043005	1331	10	19108	49	ATP1A2,SLC1A2,PARD3,DTNA,SLC1A3,CTNND2,BMPR1B,CTNNA2,CLU,GPM6A
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	RYR3,ATP1A2,PARD3,DTNA
1.781e-03	-6.33	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	49	ACSS1,ATP1A2,PARD3B,TRPS1,PREX2,MACF1,CDH20,DTNA,NTM,PARD3,NPAS3,ZBTB20,PTGDS,MAML2,SFXN5,RYR3,LSAMP,MSI2,FBXL7,NHSL1,SLC1A3,PRKG1,CTNND2,TRPM3,SOX5,FGFR3,SLC4A4,ATP13A4,SORBS1,PTPRZ1,CST3,ZNRF3,ERBB4,BMPR1B,GPC5,CLU,GLIS3,TNIK,SLC1A2,RORA,LRIG1
1.803e-03	-6.32	relaxation of muscle	biological process	GO:0090075	23	2	18204	50	ATP1A2,PRKG1
1.832e-03	-6.30	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	48	ATP13A4,ATP1A2
1.832e-03	-6.30	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	48	ATP1A2,ATP13A4
1.913e-03	-6.26	human chr10p11.22-p11.21	chromosome location	human chr10p11.22-p11.21	1	1	26134	50	PARD3
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr10q11.23-q21.1	chromosome location	human chr10q11.23-q21.1	1	1	26134	50	PRKG1
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.928e-03	-6.25	anchoring junction	cellular component	GO:0070161	902	8	19108	49	FGFR3,PARD3,SORBS1,PARD3B,ATP1A2,CDH20,CTNNA2,CTNND2
1.997e-03	-6.22	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	21	ATP1A2,SLC4A4
1.997e-03	-6.22	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	21	SLC4A4,ATP1A2
2.018e-03	-6.21	back	COSMIC cancer mutations	back	310	5	16828	49	PREX2,ATP1A2,ERBB4,TNIK,FGFR3
2.019e-03	-6.21	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	22	16828	49	CLU,RORA,GLIS3,SORBS1,PTPRZ1,ZNRF3,CTNND2,TRPM3,FGFR3,NHSL1,SLC1A3,MAML2,RYR3,NPAS3,PARD3,NFIA,PREX2,CDH20,MACF1,TRPS1,SPARCL1,PARD3B
2.021e-03	-6.20	skin-face-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-face-malignant_melanoma-lentigo_maligna	23	2	16828	49	PREX2,FGFR3
2.047e-03	-6.19	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	3	19454	50	SORBS1,PARD3,FGFR3
2.090e-03	-6.17	regulation of small molecule metabolic process	biological process	GO:0062012	331	5	18204	50	PRKG1,ZBTB20,SORBS1,SLC4A4,RORA
2.130e-03	-6.15	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	50	SLC1A3,SLC1A2
2.146e-03	-6.14	synapse organization	biological process	GO:0050808	333	5	18204	50	NFIA,CTNND2,ERBB4,GPM6A,SPARCL1
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	DTNA,CDH20,CTNNA2
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	DTNA,ABLIM1
2.226e-03	-6.11	membrane	cellular component	GO:0016020	9220	34	19108	49	SLC1A2,LSAMP,NKAIN3,CTNNA2,DTNA,HIF3A,ATP13A4,PREX2,NTM,CST3,MACF1,SFXN5,PARD3B,PTPRZ1,CTNND2,RYR3,GPC5,PTGDS,TRPM3,GPM6A,SLC4A4,FGFR3,BMPR1B,ZNRF3,TNIK,PARD3,LRIG1,PRKG1,CDH20,ERBB4,ATP1A2,CLU,SORBS1,SLC1A3
2.282e-03	-6.08	transmembrane transporter activity	molecular function	GO:0022857	1110	9	18094	48	SFXN5,SLC1A3,RYR3,SLC1A2,TRPM3,SLC4A4,GPM6A,ATP1A2,ATP13A4
2.304e-03	-6.07	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	50	SLC1A2,SLC1A3
2.319e-03	-6.07	CTNNB1 (catenin beta 1)	protein interactions	1499	926	8	19454	50	SORBS1,PARD3,CTNND2,PARD3B,PTPRZ1,NHSL1,CTNNA2,DTNA
2.328e-03	-6.06	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	31	SLC1A2,SLC1A3
2.345e-03	-6.06	LRRC7 (leucine rich repeat containing 7)	protein interactions	57554	28	2	19454	50	CTNND2,ERBB4
2.476e-03	-6.00	parathyroid	COSMIC cancer mutations	parathyroid	476	6	16828	49	TRPS1,GPM6A,RYR3,MACF1,PRKG1,GPC5
2.478e-03	-6.00	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	43	ATP1A2,ATP13A4
2.512e-03	-5.99	cell differentiation	biological process	GO:0030154	3645	19	18204	50	SLC1A3,PTPRZ1,PREX2,NTM,CLU,TNIK,PARD3,ERBB4,BMPR1B,SOX5,PRKG1,GPM6A,RORA,NHSL1,CTNND2,CTNNA2,FGFR3,MSI2,NFIA
2.514e-03	-5.99	INSC (INSC spindle orientation adaptor protein)	protein interactions	387755	29	2	19454	50	PARD3B,PARD3
2.537e-03	-5.98	cellular developmental process	biological process	GO:0048869	3648	19	18204	50	PRKG1,PARD3,BMPR1B,ERBB4,SOX5,TNIK,CLU,NTM,SLC1A3,PTPRZ1,PREX2,NFIA,FGFR3,MSI2,CTNNA2,CTNND2,NHSL1,RORA,GPM6A
2.550e-03	-5.97	non_small_cell_carcinoma	COSMIC cancer mutations	non_small_cell_carcinoma	5198	25	16828	49	FBXL7,TRPS1,SLC1A3,SPARCL1,CTNND2,SOX5,PREX2,PRKG1,ATP13A4,FGFR3,HIF3A,ABLIM1,PTPRZ1,PARD3,NPAS3,BMPR1B,ERBB4,MAML2,CLU,PITPNC1,MSI2,LSAMP,RORA,LRIG1,TNIK
2.550e-03	-5.97	lung-carcinoma-non_small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-non_small_cell_carcinoma	5198	25	16828	49	PRKG1,SOX5,CTNND2,FGFR3,ATP13A4,FBXL7,SLC1A3,CLU,TNIK,RORA,LRIG1,PTPRZ1,BMPR1B,ERBB4,PREX2,SPARCL1,TRPS1,PITPNC1,MAML2,MSI2,LSAMP,ABLIM1,HIF3A,NPAS3,PARD3
2.556e-03	-5.97	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	7	16828	49	FGFR3,TNIK,PREX2,PRKG1,BMPR1B,ERBB4,TRPS1
2.564e-03	-5.97	perinuclear endoplasmic reticulum lumen	cellular component	GO:0099020	1	1	19108	49	CLU
2.570e-03	-5.96	fgf3.L (fibroblast growth factor 3 L homeolog)	protein interactions	373669	1	1	19454	50	FGFR3
2.570e-03	-5.96	Sh2b1 (SH2B adaptor protein 1)	protein interactions	20399	1	1	19454	50	FGFR3
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.577e-03	-5.96	upper_back	COSMIC cancer mutations	upper_back	328	5	16828	49	ERBB4,PARD3B,FGFR3,MACF1,GPC5
2.602e-03	-5.95	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	7	18094	48	ATP1A2,GPM6A,SLC4A4,TRPM3,SLC1A2,RYR3,SLC1A3
2.614e-03	-5.95	response to alkaloid	biological process	GO:0043279	100	3	18204	50	SLC1A3,RYR3,SLC1A2
2.626e-03	-5.94	embryonal	COSMIC cancer mutations	embryonal	2659	16	16828	49	MAML2,RYR3,RORA,GLIS3,SORBS1,PTPRZ1,ZNRF3,NPAS3,CTNND2,TRPM3,NFIA,PREX2,FGFR3,MACF1,SPARCL1,PARD3B
2.626e-03	-5.94	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	16	16828	49	FGFR3,MACF1,PREX2,NFIA,CTNND2,TRPM3,SPARCL1,PARD3B,GLIS3,RYR3,RORA,MAML2,ZNRF3,NPAS3,SORBS1,PTPRZ1
2.670e-03	-5.93	glial cell proliferation	biological process	GO:0014009	28	2	18204	50	NFIA,CLU
2.671e-03	-5.93	human chr20p11.21	chromosome location	human chr20p11.21	40	2	26134	50	CST3,ACSS1
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A3,SLC1A2
2.698e-03	-5.92	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	3	19454	50	MSI2,RYR3,ERBB4
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	Clusterin_CS	interpro domains	IPR033986	1	1	18521	50	CLU
2.700e-03	-5.91	Clusterin	interpro domains	IPR016016	1	1	18521	50	CLU
2.700e-03	-5.91	PKcGMP_CC	interpro domains	IPR031831	1	1	18521	50	PRKG1
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	MAML2_TAD	interpro domains	IPR048452	1	1	18521	50	MAML2
2.700e-03	-5.91	ZNRF3_Znf_RING	interpro domains	IPR045903	1	1	18521	50	ZNRF3
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	ERBB4,PTPRZ1,CST3,GLIS3,TNIK,LRIG1,RORA,GPC5,SLC1A3,NHSL1,NKAIN3,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,NPAS3,PARD3,ZBTB20,DTNA,ABLIM1,NTM,HIF3A,LSAMP,PTGDS,PITPNC1,SFXN5,MAML2,TRPS1,PREX2,BMPR1B,ZNRF3,SORBS1,SLC1A2,CLU,FBXL7,SLC4A4,TRPM3,RYR3,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,NFIA
2.747e-03	-5.90	regulation of neuronal signal transduction	biological process	GO:1902847	1	1	18204	50	CLU
2.747e-03	-5.90	positive regulation of neurofibrillary tangle assembly	biological process	GO:1902998	1	1	18204	50	CLU
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.747e-03	-5.90	negative regulation of elastin catabolic process	biological process	GO:0060311	1	1	18204	50	CST3
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.747e-03	-5.90	negative regulation of collagen catabolic process	biological process	GO:0010711	1	1	18204	50	CST3
2.774e-03	-5.89	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	6	16828	49	FGFR3,MACF1,BMPR1B,ERBB4,TNIK,PRKG1
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	PTPRZ1,CST3,ERBB4,GPC5,TNIK,GLIS3,RORA,LRIG1,NHSL1,SLC1A3,PRKG1,RFX4,CTNND2,SOX5,FGFR3,NKAIN3,ATP13A4,DTNA,HIF3A,ABLIM1,NTM,PARD3,NPAS3,ZBTB20,PTGDS,PITPNC1,SFXN5,MAML2,LSAMP,TRPS1,PREX2,SORBS1,ZNRF3,BMPR1B,CLU,SLC1A2,FBXL7,TRPM3,SLC4A4,RYR3,ACSS1,ATP1A2,GPM6A,SPARCL1,PARD3B,NFIA,MACF1,CDH20
2.810e-03	-5.87	FGFR3_TM	pfam domains	PF21165	1	1	17795	50	FGFR3
2.810e-03	-5.87	PKcGMP_CC	pfam domains	PF16808	1	1	17795	50	PRKG1
2.810e-03	-5.87	MAML2_TAD	pfam domains	PF20804	1	1	17795	50	MAML2
2.853e-03	-5.86	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	5	19454	50	FGFR3,PARD3,MACF1,BMPR1B,PRKG1
2.857e-03	-5.86	cell body	cellular component	GO:0044297	556	6	19108	49	BMPR1B,CTNND2,SLC1A3,ATP1A2,GPM6A,SLC1A2
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CDH20,CTNNA2
2.870e-03	-5.85	SH2B1 (SH2B adaptor protein 1)	protein interactions	25970	31	2	19454	50	FGFR3,ERBB4
2.870e-03	-5.85	SH2D1B (SH2 domain containing 1B)	protein interactions	117157	31	2	19454	50	ERBB4,ABLIM1
2.919e-03	-5.84	non_seminoma	COSMIC cancer mutations	non_seminoma	492	6	16828	49	PRKG1,FGFR3,MACF1,TNIK,ERBB4,BMPR1B
2.972e-03	-5.82	-	gene3d domains	6.10.250.880	1	1	14470	43	ERBB4
2.972e-03	-5.82	-	gene3d domains	6.10.250.1740	1	1	14470	43	FGFR3
2.991e-03	-5.81	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	3	19454	50	NFIA,TRPS1,SOX5
2.993e-03	-5.81	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	8	19454	50	SORBS1,PARD3,MACF1,NHSL1,PARD3B,PITPNC1,ABLIM1,FGFR3
3.002e-03	-5.81	neural precursor cell proliferation	biological process	GO:0061351	105	3	18204	50	NFIA,SOX5,RORA
3.014e-03	-5.80	t(4;14) translocations of FGFR3	REACTOME pathways	R-HSA-2033515	1	1	10285	31	FGFR3
3.028e-03	-5.80	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	10	16828	49	CTNND2,ATP13A4,RYR3,TNIK,FGFR3,MACF1,ABLIM1,NTM,GPM6A,TRPS1
3.028e-03	-5.80	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	10	16828	49	ABLIM1,NTM,GPM6A,TRPS1,CTNND2,ATP13A4,RYR3,FGFR3,MACF1,TNIK
3.044e-03	-5.79	glial cell differentiation	biological process	GO:0010001	219	4	18204	50	CLU,NFIA,PTPRZ1,PARD3
3.055e-03	-5.79	CDH1 (cadherin 1)	protein interactions	999	757	7	19454	50	SORBS1,MACF1,PARD3,CTNND2,NHSL1,CTNNA2,ABLIM1
3.062e-03	-5.79	L-glutamate import	biological process	GO:0051938	30	2	18204	50	SLC1A2,SLC1A3
3.132e-03	-5.77	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	14	16828	49	SLC4A4,FGFR3,SOX5,PREX2,PRKG1,NFIA,TRPS1,PARD3B,ATP1A2,TNIK,BMPR1B,ERBB4,PTPRZ1,DTNA
3.219e-03	-5.74	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	4	16828	49	PRKG1,NTM,ATP13A4,SLC4A4
3.222e-03	-5.74	SMAD7 (SMAD family member 7)	protein interactions	4092	115	3	19454	50	PARD3,BMPR1B,SOX5
3.225e-03	-5.74	axonogenesis	biological process	GO:0007409	366	5	18204	50	PARD3,BMPR1B,CTNNA2,PTPRZ1,PRKG1
3.309e-03	-5.71	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	8	16828	49	PREX2,PRKG1,MACF1,FGFR3,TNIK,TRPS1,ERBB4,BMPR1B
3.349e-03	-5.70	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	19	16828	49	GPC5,MAML2,TNIK,LRIG1,RYR3,PTPRZ1,ABLIM1,PARD3,ZBTB20,PREX2,SOX5,TRPM3,CTNND2,MACF1,SLC4A4,GPM6A,NHSL1,ATP1A2,SPARCL1
3.371e-03	-5.69	middle_third	COSMIC cancer mutations	middle_third	3533	19	16828	49	CTNND2,TRPM3,SOX5,PREX2,SLC4A4,MACF1,ATP1A2,GPM6A,NHSL1,SPARCL1,MAML2,GPC5,RYR3,LRIG1,TNIK,ABLIM1,PTPRZ1,ZBTB20,PARD3
3.391e-03	-5.69	Ion channel transport	REACTOME pathways	R-HSA-983712	209	4	10285	31	TRPM3,ATP13A4,ATP1A2,RYR3
3.394e-03	-5.69	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	7	10285	31	ATP13A4,ATP1A2,SLC4A4,SLC1A3,TRPM3,RYR3,SLC1A2
3.401e-03	-5.68	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	5	18521	50	TNIK,FGFR3,PRKG1,ERBB4,BMPR1B
3.415e-03	-5.68	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	50	ATP13A4,ATP1A2
3.430e-03	-5.68	skin-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-malignant_melanoma-acral_lentiginous	30	2	16828	49	PREX2,FGFR3
3.430e-03	-5.68	lentigo_maligna	COSMIC cancer mutations	lentigo_maligna	30	2	16828	49	FGFR3,PREX2
3.445e-03	-5.67	brain development	biological process	GO:0007420	724	7	18204	50	SLC1A2,RFX4,RORA,ATP1A2,PRKG1,ERBB4,CTNNA2
3.468e-03	-5.66	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	31	16828	49	NHSL1,FBXL7,SLC1A3,RFX4,PRKG1,SOX5,CTNND2,NKAIN3,FGFR3,ATP13A4,SLC4A4,ERBB4,BMPR1B,CLU,GPC5,GLIS3,LRIG1,SLC1A2,RORA,ACSS1,GPM6A,ATP1A2,PREX2,MACF1,CDH20,ABLIM1,PARD3,MAML2,SFXN5,LSAMP,RYR3
3.479e-03	-5.66	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	50	SOX5,BMPR1B
3.479e-03	-5.66	centrosome localization	biological process	GO:0051642	32	2	18204	50	PARD3,PARD3B
3.479e-03	-5.66	transepithelial transport	biological process	GO:0070633	32	2	18204	50	SLC1A3,SLC1A2
3.479e-03	-5.66	positive regulation of ATP metabolic process	biological process	GO:1903580	32	2	18204	50	ZBTB20,SLC4A4
3.479e-03	-5.66	microtubule organizing center localization	biological process	GO:0061842	32	2	18204	50	PARD3,PARD3B
3.529e-03	-5.65	CLUSTERIN_2	prosite domains	PS00493	1	1	12186	43	CLU
3.529e-03	-5.65	CLUSTERIN_1	prosite domains	PS00492	1	1	12186	43	CLU
3.531e-03	-5.65	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	3	16828	49	PARD3,GPC5,PRKG1
3.621e-03	-5.62	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	41	16828	49	MACF1,CDH20,PREX2,PARD3B,TRPS1,ACSS1,ATP1A2,LSAMP,RYR3,MSI2,PTGDS,MAML2,SFXN5,PARD3,NPAS3,ZBTB20,DTNA,NTM,FGFR3,ATP13A4,SLC4A4,PRKG1,SOX5,CTNND2,TRPM3,SLC1A3,NHSL1,FBXL7,GLIS3,TNIK,SLC1A2,RORA,LRIG1,CLU,GPC5,BMPR1B,ERBB4,ZNRF3,PTPRZ1,SORBS1,CST3
3.624e-03	-5.62	upper_leg	COSMIC cancer mutations	upper_leg	880	8	16828	49	ERBB4,ACSS1,HIF3A,FGFR3,GLIS3,LRIG1,PREX2,NFIA
3.637e-03	-5.62	Cation_ATPase	pfam domains	PF13246	32	2	17795	50	ATP13A4,ATP1A2
3.688e-03	-5.60	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	3	18094	48	SLC4A4,SLC1A3,SLC1A2
3.688e-03	-5.60	calcium channel activity	molecular function	GO:0005262	117	3	18094	48	TRPM3,GPM6A,RYR3
3.697e-03	-5.60	response to auditory stimulus	biological process	GO:0010996	33	2	18204	50	SLC1A3,ATP1A2
3.741e-03	-5.59	connective tissue development	biological process	GO:0061448	232	4	18204	50	NFIA,SOX5,BMPR1B,FGFR3
3.785e-03	-5.58	regulation of circadian rhythm	biological process	GO:0042752	114	3	18204	50	RORA,PTGDS,PRKG1
3.792e-03	-5.57	PAS	interpro domains	IPR000014	34	2	18521	50	NPAS3,HIF3A
3.792e-03	-5.57	PAS-like_dom_sf	interpro domains	IPR035965	34	2	18521	50	HIF3A,NPAS3
3.808e-03	-5.57	DELLA	smart domains	SM01129	1	1	9717	37	MACF1
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A2,SLC1A3
3.908e-03	-5.54	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	8	16828	49	PTPRZ1,ABLIM1,ATP1A2,NPAS3,SPARCL1,PTGDS,FGFR3,LRIG1
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	NTM,LSAMP,LRIG1,FGFR3
3.923e-03	-5.54	seminoma	COSMIC cancer mutations	seminoma	700	7	16828	49	TRPS1,ERBB4,BMPR1B,TNIK,FGFR3,PREX2,PRKG1
3.969e-03	-5.53	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	4	19454	50	ERBB4,TNIK,NHSL1,SORBS1
3.979e-03	-5.53	glutamatergic synapse	cellular component	GO:0098978	412	5	19108	49	ERBB4,SLC1A2,TNIK,GPM6A,SPARCL1
3.982e-03	-5.53	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	3	10285	31	SLC4A4,SLC1A3,SLC1A2
4.005e-03	-5.52	PAS	smart domains	SM00091	25	2	9717	37	NPAS3,HIF3A
4.071e-03	-5.50	HPCA (hippocalcin)	protein interactions	3208	37	2	19454	50	CST3,GPM6A
4.071e-03	-5.50	MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2)	protein interactions	9863	37	2	19454	50	ERBB4,CTNND2
4.238e-03	-5.46	extraskeletal	COSMIC cancer mutations	extraskeletal	903	8	16828	49	SPARCL1,NPAS3,PTPRZ1,ATP1A2,ABLIM1,FGFR3,LRIG1,PTGDS
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP13A4,ATP1A2
4.370e-03	-5.43	striated muscle contraction	biological process	GO:0006941	120	3	18204	50	ATP1A2,DTNA,RYR3
4.470e-03	-5.41	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	9	16828	49	GPC5,PRKG1,SOX5,ATP13A4,RYR3,CDH20,SLC1A2,ERBB4,PARD3
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP13A4,ATP1A2
4.616e-03	-5.38	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	28	16828	49	PREX2,NFIA,MACF1,ATP1A2,MAML2,PITPNC1,RYR3,ABLIM1,NTM,ZBTB20,PARD3,SOX5,TRPM3,CTNND2,RFX4,PRKG1,ATP13A4,SLC4A4,FGFR3,CLU,GPC5,LRIG1,RORA,TNIK,PTPRZ1,ERBB4,BMPR1B,ZNRF3
4.616e-03	-5.38	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	28	16828	49	ATP13A4,SLC4A4,FGFR3,CTNND2,TRPM3,SOX5,PRKG1,RFX4,ZNRF3,ERBB4,BMPR1B,PTPRZ1,LRIG1,RORA,TNIK,GPC5,CLU,ATP1A2,MACF1,PREX2,NFIA,ZBTB20,PARD3,ABLIM1,NTM,RYR3,MAML2,PITPNC1
4.631e-03	-5.38	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	50	SORBS1,SLC1A2
4.631e-03	-5.38	positive regulation of purine nucleotide metabolic process	biological process	GO:1900544	37	2	18204	50	SLC4A4,ZBTB20
4.631e-03	-5.38	positive regulation of nucleotide metabolic process	biological process	GO:0045981	37	2	18204	50	ZBTB20,SLC4A4
4.691e-03	-5.36	monoatomic cation transport	biological process	GO:0006812	766	7	18204	50	RYR3,TRPM3,SLC4A4,GPM6A,ATP1A2,SLC1A3,ATP13A4
4.873e-03	-5.32	PDZ	pfam domains	PF00595	122	3	17795	50	PARD3B,PREX2,PARD3
4.880e-03	-5.32	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	50	SLC1A3,SLC1A2
4.915e-03	-5.32	transcription cis-regulatory region binding	molecular function	GO:0000976	1485	10	18094	48	SOX5,NPAS3,GLIS3,RFX4,HIF3A,ZBTB20,ERBB4,NFIA,RORA,TRPS1
4.962e-03	-5.31	transcription regulatory region nucleic acid binding	molecular function	GO:0001067	1487	10	18094	48	RFX4,HIF3A,ZBTB20,NPAS3,SOX5,GLIS3,NFIA,RORA,TRPS1,ERBB4
4.963e-03	-5.31	head development	biological process	GO:0060322	774	7	18204	50	SLC1A2,RFX4,RORA,ATP1A2,PRKG1,ERBB4,CTNNA2
4.969e-03	-5.30	intracellular chemical homeostasis	biological process	GO:0055082	581	6	18204	50	ZBTB20,SLC1A3,ATP1A2,ATP13A4,RYR3,SLC4A4
4.969e-03	-5.30	PAS	prosite domains	PS50112	30	2	12186	43	HIF3A,NPAS3
4.980e-03	-5.30	RASSF7 (Ras association domain family member 7)	protein interactions	8045	41	2	19454	50	CLU,PARD3
5.097e-03	-5.28	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	43	ATP13A4,ATP1A2
5.097e-03	-5.28	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	43	ATP13A4,ATP1A2
5.109e-03	-5.28	forebrain development	biological process	GO:0030900	408	5	18204	50	SLC1A2,PRKG1,RFX4,ERBB4,ATP1A2
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	RYR3,MACF1,SPARCL1,DTNA
5.127e-03	-5.27	RHOB (ras homolog family member B)	protein interactions	388	832	7	19454	50	PARD3,MACF1,TNIK,SLC1A3,ABLIM1,DTNA,PARD3B
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	cdh11.S (cadherin 11 S homeolog)	protein interactions	100337621	2	1	19454	50	ERBB4
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	TRIM39-RPP21 (TRIM39-RPP21 readthrough)	protein interactions	202658	2	1	19454	50	PRKG1
5.134e-03	-5.27	olfactory lobe development	biological process	GO:0021988	39	2	18204	50	ATP1A2,ERBB4
5.134e-03	-5.27	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	50	ATP1A2,SLC1A3
5.135e-03	-5.27	prostate	COSMIC cancer mutations	prostate	13883	47	16828	49	RYR3,MSI2,NFIA,CDH20,MACF1,ATP1A2,GPM6A,ACSS1,SPARCL1,PARD3B,CLU,SLC1A2,SORBS1,ZNRF3,BMPR1B,TRPM3,SLC4A4,FBXL7,SFXN5,MAML2,PITPNC1,LSAMP,HIF3A,NTM,ABLIM1,DTNA,ZBTB20,PARD3,NPAS3,PREX2,TRPS1,GPC5,RORA,LRIG1,TNIK,GLIS3,PTPRZ1,ERBB4,CTNND2,SOX5,PRKG1,RFX4,ATP13A4,FGFR3,NKAIN3,NHSL1,SLC1A3
5.154e-03	-5.27	spindle	COSMIC cancer mutations	spindle	386	5	16828	49	TRPM3,CTNND2,PREX2,FGFR3,MACF1
5.157e-03	-5.27	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	8	16828	49	PRKG1,PREX2,TNIK,FGFR3,MACF1,ATP1A2,BMPR1B,ERBB4
5.251e-03	-5.25	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	3	16828	49	DTNA,FGFR3,CDH20
5.299e-03	-5.24	cGMP-dependent protein kinase activity	molecular function	GO:0004692	2	1	18094	48	PRKG1
5.366e-03	-5.23	NFIB (nuclear factor I B)	protein interactions	4781	138	3	19454	50	TRPS1,SOX5,NFIA
5.373e-03	-5.23	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	11	18204	50	ATP1A2,RORA,ZBTB20,MACF1,SFXN5,PTPRZ1,CLU,PARD3,SOX5,BMPR1B,ERBB4
5.392e-03	-5.22	STKc_cGK	interpro domains	IPR035014	2	1	18521	50	PRKG1
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	Ac_CoA_lig	interpro domains	IPR011904	2	1	18521	50	ACSS1
5.392e-03	-5.22	ZNRF-3_ecto	interpro domains	IPR040700	2	1	18521	50	ZNRF3
5.392e-03	-5.22	cGMP_dep_kinase	interpro domains	IPR002374	2	1	18521	50	PRKG1
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Clusterin_C	interpro domains	IPR016015	2	1	18521	50	CLU
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Clusterin_N	interpro domains	IPR016014	2	1	18521	50	CLU
5.392e-03	-5.22	Clusterin-like	interpro domains	IPR000753	2	1	18521	50	CLU
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.422e-03	-5.22	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	13	16828	49	TNIK,DTNA,PTPRZ1,ERBB4,BMPR1B,NFIA,PRKG1,PREX2,SOX5,FGFR3,SLC4A4,ATP1A2,TRPS1
5.486e-03	-5.21	acetyl-CoA biosynthetic process from acetate	biological process	GO:0019427	2	1	18204	50	ACSS1
5.486e-03	-5.21	Wnt receptor catabolic process	biological process	GO:0038018	2	1	18204	50	ZNRF3
5.486e-03	-5.21	negative regulation of blood vessel remodeling	biological process	GO:0060313	2	1	18204	50	CST3
5.486e-03	-5.21	regulation of neurofibrillary tangle assembly	biological process	GO:1902996	2	1	18204	50	CLU
5.486e-03	-5.21	fibroblast growth factor receptor apoptotic signaling pathway	biological process	GO:1902178	2	1	18204	50	FGFR3
5.486e-03	-5.21	negative regulation of inositol phosphate biosynthetic process	biological process	GO:0010920	2	1	18204	50	PRKG1
5.486e-03	-5.21	regulation of elastin catabolic process	biological process	GO:0060310	2	1	18204	50	CST3
5.486e-03	-5.21	propionate biosynthetic process	biological process	GO:0019542	2	1	18204	50	ACSS1
5.486e-03	-5.21	acetate biosynthetic process	biological process	GO:0019413	2	1	18204	50	ACSS1
5.486e-03	-5.21	establishment of planar polarity involved in nephron morphogenesis	biological process	GO:0072046	2	1	18204	50	ERBB4
5.492e-03	-5.20	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	4	18094	48	SLC4A4,SLC1A2,SFXN5,SLC1A3
5.505e-03	-5.20	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	7	16828	49	PARD3,ERBB4,PREX2,CDH20,ATP13A4,FGFR3,MACF1
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A2,SLC1A3
5.547e-03	-5.19	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	50	ERBB4,BMPR1B,FGFR3
5.612e-03	-5.18	Clusterin	pfam domains	PF01093	2	1	17795	50	CLU
5.612e-03	-5.18	ZNRF_3_ecto	pfam domains	PF18212	2	1	17795	50	ZNRF3
5.612e-03	-5.18	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	48	RYR3,GPM6A,TRPM3
5.696e-03	-5.17	SNTB2 (syntrophin beta 2)	protein interactions	6645	141	3	19454	50	FGFR3,ERBB4,DTNA
5.697e-03	-5.17	amino acid transport	biological process	GO:0006865	132	3	18204	50	SLC1A2,SLC1A3,SFXN5
5.766e-03	-5.16	axon development	biological process	GO:0061564	420	5	18204	50	PRKG1,PTPRZ1,CTNNA2,BMPR1B,PARD3
5.802e-03	-5.15	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	4	16828	49	NPAS3,ERBB4,GPC5,NFIA
5.802e-03	-5.15	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	4	16828	49	GPC5,NFIA,NPAS3,ERBB4
5.813e-03	-5.15	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	3	17795	50	ERBB4,BMPR1B,FGFR3
5.885e-03	-5.14	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	4	16828	49	FGFR3,MACF1,GLIS3,PTPRZ1
5.935e-03	-5.13	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	43	CTNNA2
5.935e-03	-5.13	-	gene3d domains	6.20.350.10	2	1	14470	43	RYR3
5.935e-03	-5.13	regulation of amino acid transport	biological process	GO:0051955	42	2	18204	50	PRKG1,ATP1A2
5.944e-03	-5.13	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	11	16828	49	PARD3B,ABLIM1,DTNA,SORBS1,PTPRZ1,CDH20,RORA,MACF1,FGFR3,CTNND2,PREX2
5.944e-03	-5.13	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	11	16828	49	RORA,ABLIM1,PTPRZ1,DTNA,SORBS1,CDH20,FGFR3,MACF1,CTNND2,PREX2,PARD3B
5.968e-03	-5.12	small_intestine	COSMIC cancer mutations	small_intestine	250	4	16828	49	MACF1,ZNRF3,FGFR3,TNIK
5.998e-03	-5.12	growth	biological process	GO:0040007	424	5	18204	50	PRKG1,SLC1A2,BMPR1B,ERBB4,FGFR3
5.998e-03	-5.12	developmental growth	biological process	GO:0048589	424	5	18204	50	PRKG1,SLC1A2,ERBB4,FGFR3,BMPR1B
6.037e-03	-5.11	Calml3 (calmodulin-like 3)	protein interactions	70405	144	3	19454	50	ABLIM1,ZBTB20,MACF1
6.108e-03	-5.10	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	5	19454	50	CTNND2,DTNA,ERBB4,MACF1,PARD3
6.237e-03	-5.08	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	5	18204	50	RYR3,ATP13A4,SLC4A4,ATP1A2,SLC1A3
6.257e-03	-5.07	active transmembrane transporter activity	molecular function	GO:0022804	444	5	18094	48	SLC1A3,SLC1A2,ATP1A2,SLC4A4,ATP13A4
6.263e-03	-5.07	PAS domain	gene3d domains	3.30.450.20	40	2	14470	43	HIF3A,NPAS3
6.272e-03	-5.07	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	4	19454	50	SORBS1,DTNA,PARD3B,PARD3
6.272e-03	-5.07	DSCR9 (Down syndrome critical region 9)	protein interactions	257203	146	3	19454	50	SPARCL1,MACF1,CLU
6.348e-03	-5.06	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	4	19454	50	PARD3,NHSL1,SORBS1,PRKG1
6.368e-03	-5.06	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	11	16828	49	MACF1,SOX5,TRPM3,PRKG1,GPC5,ZBTB20,ERBB4,PARD3,NPAS3,HIF3A,PTPRZ1
6.441e-03	-5.04	regulation of generation of precursor metabolites and energy	biological process	GO:0043467	138	3	18204	50	SLC4A4,SORBS1,ZBTB20
6.454e-03	-5.04	leg	COSMIC cancer mutations	leg	969	8	16828	49	ATP13A4,SLC4A4,FGFR3,PRKG1,ZBTB20,NTM,HIF3A,PTPRZ1
6.493e-03	-5.04	spleen	COSMIC cancer mutations	spleen	408	5	16828	49	SORBS1,PTPRZ1,NTM,PARD3B,TNIK
6.498e-03	-5.04	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	50	SORBS1,SLC1A2
6.500e-03	-5.04	CNTN1 (contactin 1)	protein interactions	1272	47	2	19454	50	PTPRZ1,GPM6A
6.500e-03	-5.04	LRIG3 (leucine rich repeats and immunoglobulin like domains 3)	protein interactions	121227	47	2	19454	50	LRIG1,ERBB4
6.545e-03	-5.03	sequence-specific double-stranded DNA binding	molecular function	GO:1990837	1547	10	18094	48	ZBTB20,HIF3A,RFX4,GLIS3,NPAS3,SOX5,RORA,TRPS1,NFIA,ERBB4
6.634e-03	-5.02	GSE1 (Gse1 coiled-coil protein)	protein interactions	23199	149	3	19454	50	NFIA,TNIK,SOX5
6.676e-03	-5.01	inorganic cation transmembrane transport	biological process	GO:0098662	618	6	18204	50	SLC1A3,ATP1A2,GPM6A,TRPM3,SLC4A4,RYR3
6.702e-03	-5.01	neurotransmitter transport	biological process	GO:0006836	140	3	18204	50	SLC1A3,ATP1A2,SLC1A2
6.709e-03	-5.00	apical junction complex	cellular component	GO:0043296	150	3	19108	49	PARD3,SORBS1,PARD3B
6.788e-03	-4.99	acidic amino acid transport	biological process	GO:0015800	45	2	18204	50	SLC1A2,SLC1A3
6.798e-03	-4.99	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	5	18204	50	RYR3,ATP1A2,SLC1A3,SLC4A4,ATP13A4
6.804e-03	-4.99	gliogenesis	biological process	GO:0042063	275	4	18204	50	PTPRZ1,PARD3,NFIA,CLU
6.875e-03	-4.98	transmembrane transport	biological process	GO:0055085	1264	9	18204	50	ATP13A4,ATP1A2,GPM6A,SLC1A3,SLC1A2,SLC4A4,SFXN5,TRPM3,RYR3
6.890e-03	-4.98	telencephalon development	biological process	GO:0021537	276	4	18204	50	RFX4,SLC1A2,ATP1A2,ERBB4
6.935e-03	-4.97	CATATPASE	prints domains	PR00119	35	2	5227	19	ATP13A4,ATP1A2
6.939e-03	-4.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	8	16828	49	GPC5,PRKG1,SOX5,CTNND2,NKAIN3,PARD3,RORA,LSAMP
6.941e-03	-4.97	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	7	16828	49	PRKG1,CTNND2,SOX5,FGFR3,ERBB4,TNIK,BMPR1B
6.941e-03	-4.97	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	7	16828	49	ERBB4,BMPR1B,FGFR3,TNIK,PRKG1,CTNND2,SOX5
6.969e-03	-4.97	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	50	SLC4A4,ZBTB20,SORBS1
6.969e-03	-4.97	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	50	SLC1A3,SLC4A4,SLC1A2
7.045e-03	-4.96	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	43	SPARCL1
7.045e-03	-4.96	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	43	SPARCL1
7.084e-03	-4.95	regulation of myelination	biological process	GO:0031641	46	2	18204	50	PARD3,PTPRZ1
7.087e-03	-4.95	symporter activity	molecular function	GO:0015293	148	3	18094	48	SLC4A4,SLC1A2,SLC1A3
7.101e-03	-4.95	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	43	ATP13A4,ATP1A2
7.135e-03	-4.94	SOX6 (SRY-box transcription factor 6)	protein interactions	55553	153	3	19454	50	SOX5,TRPS1,NFIA
7.175e-03	-4.94	PDZ	interpro domains	IPR001478	146	3	18521	50	PARD3B,PARD3,PREX2
7.257e-03	-4.93	CGMPKINASE	prints domains	PR00104	2	1	5227	19	PRKG1
7.312e-03	-4.92	metal ion transport	biological process	GO:0030001	630	6	18204	50	TRPM3,SLC4A4,RYR3,SLC1A3,ATP1A2,GPM6A
7.456e-03	-4.90	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	9	16828	49	LSAMP,RORA,NKAIN3,TNIK,CTNND2,SOX5,GPC5,PRKG1,PARD3
7.493e-03	-4.89	cell surface	cellular component	GO:0009986	896	7	19108	49	SLC1A3,SLC4A4,FGFR3,CLU,ATP1A2,SLC1A2,GPC5
7.515e-03	-4.89	Wnt signaling pathway	biological process	GO:0016055	283	4	18204	50	MACF1,TNIK,CTNND2,ZNRF3
7.521e-03	-4.89	adult behavior	biological process	GO:0030534	146	3	18204	50	PREX2,ATP1A2,SLC1A2
7.587e-03	-4.88	PDZ_sf	interpro domains	IPR036034	149	3	18521	50	PARD3B,PARD3,PREX2
7.592e-03	-4.88	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	49	MACF1,ZNRF3
7.592e-03	-4.88	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	49	ZNRF3,MACF1
7.601e-03	-4.88	CLa	smart domains	SM00035	2	1	9717	37	CLU
7.601e-03	-4.88	CLb	smart domains	SM00030	2	1	9717	37	CLU
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	NHSL1,MACF1
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Hk2 (hexokinase 2)	protein interactions	25059	3	1	19454	50	PTGDS
7.691e-03	-4.87	NRG3 (neuregulin 3)	protein interactions	10718	3	1	19454	50	ERBB4
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Lep (leptin)	protein interactions	16846	3	1	19454	50	CLU
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.720e-03	-4.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	10	16828	49	SORBS1,PARD3,TRPS1,GPC5,CTNND2,TRPM3,TNIK,RYR3,SLC4A4,LSAMP
7.761e-03	-4.86	C20 prostanoid biosynthesis	BIOCYC pathways	META_PWY66-374	7	1	902	1	PTGDS
7.761e-03	-4.86	C20 prostanoid biosynthesis	BIOCYC pathways	HUMAN_PWY66-374	7	1	902	1	PTGDS
7.909e-03	-4.84	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	50	ERBB4,SORBS1
7.909e-03	-4.84	SNAP91 (synaptosome associated protein 91)	protein interactions	9892	52	2	19454	50	ERBB4,GPM6A
7.938e-03	-4.84	epidermal growth factor receptor activity	molecular function	GO:0005006	3	1	18094	48	ERBB4
7.938e-03	-4.84	prostaglandin-D synthase activity	molecular function	GO:0004667	3	1	18094	48	PTGDS
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.938e-03	-4.84	neuregulin receptor activity	molecular function	GO:0038131	3	1	18094	48	ERBB4
8.061e-03	-4.82	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	5	16828	49	PRKG1,FGFR3,BMPR1B,ERBB4,TNIK
8.061e-03	-4.82	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	5	16828	49	PRKG1,BMPR1B,ERBB4,TNIK,FGFR3
8.065e-03	-4.82	SOX5 (SRY-box transcription factor 5)	protein interactions	6660	160	3	19454	50	NFIA,TRPS1,SOX5
8.078e-03	-4.82	MAML_N_sf	interpro domains	IPR046370	3	1	18521	50	MAML2
8.078e-03	-4.82	MAML1-3	interpro domains	IPR046369	3	1	18521	50	MAML2
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	50	HIF3A
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	TM_ErbB1	interpro domains	IPR049328	3	1	18521	50	ERBB4
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	Mastermind-like_N	interpro domains	IPR019082	3	1	18521	50	MAML2
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.085e-03	-4.82	signaling	biological process	GO:0023052	4968	22	18204	50	PREX2,SLC1A3,CLU,MAML2,PARD3,ERBB4,BMPR1B,TNIK,PRKG1,RORA,ATP1A2,SLC1A2,ZNRF3,PITPNC1,SORBS1,DTNA,CTNND2,FGFR3,SPARCL1,MACF1,NFIA,RYR3
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	PARD3,MACF1,DTNA,SORBS1
8.124e-03	-4.81	neuronal cell body	cellular component	GO:0043025	489	5	19108	49	GPM6A,ATP1A2,CTNND2,SLC1A3,BMPR1B
8.218e-03	-4.80	acetate metabolic process	biological process	GO:0006083	3	1	18204	50	ACSS1
8.218e-03	-4.80	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	50	CTNNA2
8.218e-03	-4.80	protein targeting to lysosome involved in chaperone-mediated autophagy	biological process	GO:0061740	3	1	18204	50	CLU
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.218e-03	-4.80	immune complex clearance	biological process	GO:0002434	3	1	18204	50	CLU
8.218e-03	-4.80	central nervous system morphogenesis	biological process	GO:0021551	3	1	18204	50	ERBB4
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.327e-03	-4.79	cell surface receptor signaling pathway via JAK-STAT	biological process	GO:0007259	50	2	18204	50	FGFR3,ERBB4
8.406e-03	-4.78	RyR	pfam domains	PF02026	3	1	17795	50	RYR3
8.406e-03	-4.78	SR_plectin_7	pfam domains	PF21097	3	1	17795	50	MACF1
8.406e-03	-4.78	RYDR_Jsol	pfam domains	PF21119	3	1	17795	50	RYR3
8.406e-03	-4.78	RR_TM4-6	pfam domains	PF06459	3	1	17795	50	RYR3
8.406e-03	-4.78	Myelin_PLP	pfam domains	PF01275	3	1	17795	50	GPM6A
8.406e-03	-4.78	Sorb	pfam domains	PF02208	3	1	17795	50	SORBS1
8.406e-03	-4.78	HIF-1	pfam domains	PF11413	3	1	17795	50	HIF3A
8.406e-03	-4.78	MamL-1	pfam domains	PF09596	3	1	17795	50	MAML2
8.406e-03	-4.78	TM_ErbB1	pfam domains	PF21314	3	1	17795	50	ERBB4
8.436e-03	-4.78	protein binding	molecular function	GO:0005515	13983	44	18094	48	CLU,FBXL7,CST3,SLC1A3,LSAMP,CTNNA2,CDH20,PARD3,ZNRF3,PTGDS,SORBS1,SPARCL1,MAML2,LRIG1,NPAS3,ATP1A2,GPC5,NFIA,MSI2,SOX5,NTM,ABLIM1,SFXN5,PRKG1,RORA,ACSS1,PTPRZ1,ERBB4,BMPR1B,RYR3,TNIK,HIF3A,TRPS1,CTNND2,FGFR3,RFX4,DTNA,SLC1A2,MACF1,SLC4A4,PITPNC1,GLIS3,PARD3B,GPM6A
8.458e-03	-4.77	DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	GO:0000981	1355	9	18094	48	HIF3A,RFX4,ZBTB20,GLIS3,SOX5,NPAS3,RORA,TRPS1,NFIA
8.478e-03	-4.77	EF-hand	gene3d domains	1.10.238.10	272	4	14470	43	SPARCL1,RYR3,MACF1,DTNA
8.507e-03	-4.77	SYNM (synemin)	protein interactions	23336	54	2	19454	50	ERBB4,DTNA
8.508e-03	-4.77	cellular component organization	biological process	GO:0016043	5636	24	18204	50	NFIA,SPARCL1,RFX4,ABLIM1,CTNND2,CST3,PRKG1,ERBB4,PARD3,PREX2,PARD3B,CDH20,RYR3,CTNNA2,MACF1,SLC1A2,PITPNC1,SORBS1,GPM6A,TNIK,TRPM3,BMPR1B,CLU,PTPRZ1
8.567e-03	-4.76	NEDD4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	4734	494	5	19454	50	FGFR3,ERBB4,TNIK,MAML2,GLIS3
8.603e-03	-4.76	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	48	2	16828	49	RYR3,PARD3
8.638e-03	-4.75	OCLN (occludin)	protein interactions	100506658	495	5	19454	50	TNIK,ABLIM1,MACF1,PARD3,DTNA
8.693e-03	-4.75	cellular response to organic cyclic compound	biological process	GO:0071407	464	5	18204	50	SLC1A2,RYR3,RORA,SLC1A3,ATP1A2
8.702e-03	-4.74	hindbrain development	biological process	GO:0030902	154	3	18204	50	PRKG1,CTNNA2,RORA
8.711e-03	-4.74	skin-trunk-lentigo	COSMIC cancer mutations	skin-trunk-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-forearm-lentigo	COSMIC cancer mutations	skin-forearm-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-hand-lentigo	COSMIC cancer mutations	skin-hand-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	urinary_tract-bladder-papilloma	COSMIC cancer mutations	urinary_tract-bladder-papilloma	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-lentigo	COSMIC cancer mutations	skin-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	lentigo	COSMIC cancer mutations	lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-leg-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-trunk-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-face-lentigo	COSMIC cancer mutations	skin-face-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-lentigo	COSMIC cancer mutations	skin-leg-lentigo	3	1	16828	49	FGFR3
8.712e-03	-4.74	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	48	ATP1A2,ATP13A4
8.736e-03	-4.74	Amyotrophic lateral sclerosis (ALS)	WikiPathways	WP2447	38	2	5310	20	SLC1A2,CST3
8.771e-03	-4.74	EGR2 (early growth response 2)	protein interactions	1959	165	3	19454	50	TRPS1,SOX5,NFIA
8.772e-03	-4.74	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	5	16828	49	PRKG1,FGFR3,BMPR1B,ERBB4,TNIK
8.836e-03	-4.73	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	4	16828	49	ERBB4,TNIK,ATP1A2,PREX2
8.873e-03	-4.72	muscle system process	biological process	GO:0003012	297	4	18204	50	ATP1A2,PRKG1,RYR3,DTNA
8.889e-03	-4.72	-	gene3d domains	1.10.490.160	3	1	14470	43	RYR3
8.889e-03	-4.72	-	gene3d domains	6.10.250.2510	3	1	14470	43	CTNNA2
8.889e-03	-4.72	-	gene3d domains	6.10.250.970	3	1	14470	43	MAML2
8.972e-03	-4.71	chest	COSMIC cancer mutations	chest	147	3	16828	49	ERBB4,FGFR3,PREX2
8.978e-03	-4.71	cell communication	biological process	GO:0007154	5010	22	18204	50	SLC1A3,PREX2,MAML2,CLU,TNIK,BMPR1B,ERBB4,PARD3,PRKG1,ATP1A2,RORA,CTNND2,DTNA,PITPNC1,SORBS1,SLC1A2,ZNRF3,MACF1,SPARCL1,FGFR3,RYR3,NFIA
8.982e-03	-4.71	regulation of nucleotide catabolic process	biological process	GO:0030811	52	2	18204	50	ZBTB20,SLC4A4
8.982e-03	-4.71	regulation of purine nucleotide catabolic process	biological process	GO:0033121	52	2	18204	50	SLC4A4,ZBTB20
8.982e-03	-4.71	regulation of glycolytic process	biological process	GO:0006110	52	2	18204	50	ZBTB20,SLC4A4
9.013e-03	-4.71	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	50	NFIA,GPM6A,BMPR1B
9.125e-03	-4.70	SEPTIN3 (septin 3)	protein interactions	55964	56	2	19454	50	GPM6A,PRKG1
9.147e-03	-4.69	presynaptic membrane	cellular component	GO:0042734	168	3	19108	49	ERBB4,GPM6A,SLC1A2
9.303e-03	-4.68	Prot_kinase_dom	interpro domains	IPR000719	480	5	18521	50	ERBB4,BMPR1B,TNIK,FGFR3,PRKG1
9.318e-03	-4.68	neutral amino acid transport	biological process	GO:0015804	53	2	18204	50	SLC1A2,SLC1A3
9.428e-03	-4.66	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	10	16828	49	PTPRZ1,SORBS1,DTNA,PARD3B,NPAS3,PREX2,GPC5,MACF1,FGFR3,RYR3
9.492e-03	-4.66	monoatomic anion transport	biological process	GO:0006820	159	3	18204	50	SLC4A4,SLC1A3,SLC1A2
9.616e-03	-4.64	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	48	16828	49	NFIA,MACF1,CDH20,ACSS1,GPM6A,ATP1A2,PARD3B,SPARCL1,RYR3,MSI2,TRPM3,SLC4A4,FBXL7,CLU,SLC1A2,SORBS1,BMPR1B,ZNRF3,PREX2,TRPS1,PTGDS,PITPNC1,SFXN5,MAML2,LSAMP,DTNA,ABLIM1,NTM,HIF3A,NPAS3,PARD3,ZBTB20,RFX4,PRKG1,SOX5,CTNND2,NKAIN3,FGFR3,ATP13A4,NHSL1,SLC1A3,GPC5,GLIS3,TNIK,RORA,LRIG1,PTPRZ1,ERBB4
9.634e-03	-4.64	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	49	16828	49	FBXL7,SLC4A4,TRPM3,BMPR1B,ZNRF3,SORBS1,SLC1A2,CLU,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,NFIA,RYR3,MSI2,SLC1A3,NHSL1,NKAIN3,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,ERBB4,PTPRZ1,CST3,TNIK,GLIS3,LRIG1,RORA,GPC5,TRPS1,PREX2,PARD3,NPAS3,ZBTB20,DTNA,NTM,ABLIM1,HIF3A,LSAMP,PITPNC1,PTGDS,SFXN5,MAML2
9.659e-03	-4.64	cell surface receptor signaling pathway via STAT	biological process	GO:0097696	54	2	18204	50	ERBB4,FGFR3
9.704e-03	-4.64	RNA polymerase II transcription regulatory region sequence-specific DNA binding	molecular function	GO:0000977	1385	9	18094	48	NFIA,RORA,TRPS1,NPAS3,SOX5,GLIS3,ZBTB20,RFX4,HIF3A
9.709e-03	-4.63	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	11	19454	50	PARD3B,BMPR1B,DTNA,TRPS1,ABLIM1,FGFR3,MSI2,NFIA,ZBTB20,MACF1,PARD3
9.762e-03	-4.63	Hippo signaling pathway	KEGG pathways	hsa04390	154	3	7161	21	PARD3,CTNNA2,BMPR1B
9.762e-03	-4.63	Hippo signaling pathway	KEGG pathways	ko04390	154	3	7161	21	PARD3,CTNNA2,BMPR1B
9.773e-03	-4.63	-	gene3d domains	2.30.42.10	149	3	14470	43	PARD3,PREX2,PARD3B
9.833e-03	-4.62	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	4	19454	50	PARD3,TNIK,DTNA,SORBS1
9.858e-03	-4.62	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	6	16828	49	ERBB4,SORBS1,PTPRZ1,NTM,PREX2,NFIA
9.877e-03	-4.62	double-stranded DNA binding	molecular function	GO:0003690	1643	10	18094	48	NFIA,RORA,TRPS1,ERBB4,ZBTB20,RFX4,HIF3A,SOX5,NPAS3,GLIS3
9.962e-03	-4.61	medullary_carcinoma	COSMIC cancer mutations	medullary_carcinoma	290	4	16828	49	PRKG1,PARD3B,FGFR3,SLC1A2
9.962e-03	-4.61	thyroid-carcinoma-medullary_carcinoma	COSMIC cancer mutations	thyroid-carcinoma-medullary_carcinoma	290	4	16828	49	SLC1A2,PARD3B,FGFR3,PRKG1
1.001e-02	-4.60	establishment or maintenance of epithelial cell apical/basal polarity	biological process	GO:0045197	55	2	18204	50	PARD3,PARD3B
1.001e-02	-4.60	response to cocaine	biological process	GO:0042220	55	2	18204	50	SLC1A3,SLC1A2
1.002e-02	-4.60	Znf_NHR/GATA	interpro domains	IPR013088	56	2	18521	50	RORA,TRPS1
1.009e-02	-4.60	VEGFA (vascular endothelial growth factor A)	protein interactions	7422	59	2	19454	50	CLU,PTPRZ1
1.012e-02	-4.59	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	5	12186	43	PRKG1,BMPR1B,TNIK,FGFR3,ERBB4
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	CTNNA2,DTNA,CDH20
1.022e-02	-4.58	internode region of axon	cellular component	GO:0033269	4	1	19108	49	PARD3
1.023e-02	-4.58	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	31	SLC1A3,SLC1A2
1.023e-02	-4.58	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	5	16828	49	PRKG1,BMPR1B,ERBB4,TNIK,FGFR3
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.025e-02	-4.58	sequence-specific DNA binding	molecular function	GO:0043565	1652	10	18094	48	ERBB4,NFIA,RORA,TRPS1,SOX5,NPAS3,GLIS3,ZBTB20,RFX4,HIF3A
1.029e-02	-4.58	LHX3 (LIM homeobox 3)	protein interactions	8022	175	3	19454	50	NFIA,SOX5,TRPS1
1.042e-02	-4.56	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	5	16828	49	FGFR3,ERBB4,TNIK,BMPR1B,PRKG1
1.042e-02	-4.56	ITGA8 (integrin subunit alpha 8)	protein interactions	8516	60	2	19454	50	CLU,ZNRF3
1.042e-02	-4.56	SNTB1 (syntrophin beta 1)	protein interactions	6641	60	2	19454	50	DTNA,FGFR3
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	ATP1A2,SLC1A3,SLC1A2
1.055e-02	-4.55	VINCULIN_1	prosite domains	PS00663	3	1	12186	43	CTNNA2
1.055e-02	-4.55	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	43	GPM6A
1.055e-02	-4.55	SOHO	prosite domains	PS50831	3	1	12186	43	SORBS1
1.055e-02	-4.55	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	43	GPM6A
1.057e-02	-4.55	acetate-CoA ligase activity	molecular function	GO:0003987	4	1	18094	48	ACSS1
1.057e-02	-4.55	propionate-CoA ligase activity	molecular function	GO:0050218	4	1	18094	48	ACSS1
1.057e-02	-4.55	tricarboxylic acid transmembrane transporter activity	molecular function	GO:0015142	4	1	18094	48	SFXN5
1.057e-02	-4.55	short-chain fatty acid-CoA ligase activity	molecular function	GO:0031955	4	1	18094	48	ACSS1
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.057e-02	-4.55	citrate transmembrane transporter activity	molecular function	GO:0015137	4	1	18094	48	SFXN5
1.072e-02	-4.54	visual behavior	biological process	GO:0007632	57	2	18204	50	ATP1A2,SLC1A2
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	Tyr_kinase_EGF/ERB/XmrK_rcpt	interpro domains	IPR016245	4	1	18521	50	ERBB4
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	FGF_rcpt_fam	interpro domains	IPR016248	4	1	18521	50	FGFR3
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	ACAS_N	interpro domains	IPR032387	4	1	18521	50	ACSS1
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	TNIK,PRKG1
1.087e-02	-4.52	RORNUCRECPTR	prints domains	PR01293	3	1	5227	19	RORA
1.087e-02	-4.52	MYELINPLP	prints domains	PR00214	3	1	5227	19	GPM6A
1.087e-02	-4.52	RYANODINER	prints domains	PR00795	3	1	5227	19	RYR3
1.087e-02	-4.52	PGNDSYNTHASE	prints domains	PR01254	3	1	5227	19	PTGDS
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	regulation of collagen catabolic process	biological process	GO:0010710	4	1	18204	50	CST3
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.094e-02	-4.52	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	50	BMPR1B
1.094e-02	-4.52	negative regulation of germ cell proliferation	biological process	GO:1905937	4	1	18204	50	PTGDS
1.094e-02	-4.52	positive regulation of inclusion body assembly	biological process	GO:0090261	4	1	18204	50	CLU
1.094e-02	-4.52	negative regulation of male germ cell proliferation	biological process	GO:2000255	4	1	18204	50	PTGDS
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.094e-02	-4.52	short-chain fatty acid biosynthetic process	biological process	GO:0051790	4	1	18204	50	ACSS1
1.094e-02	-4.52	cardiac muscle tissue regeneration	biological process	GO:0061026	4	1	18204	50	ERBB4
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.096e-02	-4.51	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	12	16828	49	ATP13A4,FGFR3,CTNND2,PREX2,SPARCL1,ATP1A2,RORA,PARD3,BMPR1B,ERBB4,ABLIM1,SORBS1
1.096e-02	-4.51	mucosal	COSMIC cancer mutations	mucosal	2009	12	16828	49	SPARCL1,ERBB4,BMPR1B,PARD3,SORBS1,ATP1A2,ABLIM1,FGFR3,ATP13A4,RORA,PREX2,CTNND2
1.096e-02	-4.51	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	7	16828	49	FGFR3,BMPR1B,ERBB4,TNIK,LRIG1,PRKG1,PTPRZ1
1.096e-02	-4.51	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	7	16828	49	ERBB4,BMPR1B,PTPRZ1,LRIG1,TNIK,FGFR3,PRKG1
1.098e-02	-4.51	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	5	16828	49	FGFR3,ERBB4,TNIK,BMPR1B,PRKG1
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	DTNA,HIF3A,NTM,ABLIM1,PARD3,NPAS3,ZBTB20,PITPNC1,PTGDS,MAML2,SFXN5,LSAMP,TRPS1,PREX2,PTPRZ1,CST3,ERBB4,GPC5,GLIS3,TNIK,RORA,LRIG1,NHSL1,SLC1A3,PRKG1,RFX4,CTNND2,SOX5,FGFR3,NKAIN3,ATP13A4,RYR3,MSI2,ACSS1,ATP1A2,GPM6A,SPARCL1,PARD3B,NFIA,MACF1,CDH20,SORBS1,ZNRF3,BMPR1B,CLU,SLC1A2,FBXL7,TRPM3,SLC4A4
1.103e-02	-4.51	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	7	16828	49	HIF3A,ACSS1,ERBB4,PREX2,NFIA,LRIG1,GLIS3
1.104e-02	-4.51	EZR (ezrin)	protein interactions	7430	526	5	19454	50	MACF1,TNIK,ABLIM1,SORBS1,DTNA
1.110e-02	-4.50	cellular homeostasis	biological process	GO:0019725	689	6	18204	50	ZBTB20,ATP13A4,ATP1A2,SLC1A3,RYR3,SLC4A4
1.110e-02	-4.50	MYOD1 (myogenic differentiation 1)	protein interactions	4654	180	3	19454	50	RORA,NFIA,TRPS1
1.110e-02	-4.50	EPHA4 (EPH receptor A4)	protein interactions	2043	180	3	19454	50	PARD3,FGFR3,CTNNA2
1.111e-02	-4.50	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	12	19108	49	SLC1A2,GPM6A,DTNA,CTNNA2,BMPR1B,PARD3,ABLIM1,ATP1A2,CLU,MACF1,CTNND2,SLC1A3
1.119e-02	-4.49	Spectrin_3	pfam domains	PF21019	4	1	17795	50	MACF1
1.119e-02	-4.49	Spectrin_4	pfam domains	PF21020	4	1	17795	50	MACF1
1.119e-02	-4.49	P5-ATPase	pfam domains	PF12409	4	1	17795	50	ATP13A4
1.119e-02	-4.49	CTF_NFI	pfam domains	PF00859	4	1	17795	50	NFIA
1.119e-02	-4.49	NKAIN	pfam domains	PF05640	4	1	17795	50	NKAIN3
1.119e-02	-4.49	Spectrin_2	pfam domains	PF18373	4	1	17795	50	MACF1
1.119e-02	-4.49	AbLIM_anchor	pfam domains	PF16182	4	1	17795	50	ABLIM1
1.119e-02	-4.49	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	50	NFIA
1.119e-02	-4.49	TRPM_tetra	pfam domains	PF16519	4	1	17795	50	TRPM3
1.119e-02	-4.49	ACAS_N	pfam domains	PF16177	4	1	17795	50	ACSS1
1.119e-02	-4.49	NHS	pfam domains	PF15273	4	1	17795	50	NHSL1
1.120e-02	-4.49	cellular response to growth factor stimulus	biological process	GO:0071363	494	5	18204	50	NFIA,FGFR3,BMPR1B,ERBB4,SOX5
1.138e-02	-4.48	Sorb	smart domains	SM00459	3	1	9717	37	SORBS1
1.138e-02	-4.48	MamL-1	smart domains	SM01275	3	1	9717	37	MAML2
1.138e-02	-4.48	PLP	smart domains	SM00002	3	1	9717	37	GPM6A
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.145e-02	-4.47	establishment or maintenance of bipolar cell polarity	biological process	GO:0061245	59	2	18204	50	PARD3,PARD3B
1.145e-02	-4.47	establishment or maintenance of apical/basal cell polarity	biological process	GO:0035088	59	2	18204	50	PARD3B,PARD3
1.145e-02	-4.47	endochondral bone morphogenesis	biological process	GO:0060350	59	2	18204	50	BMPR1B,FGFR3
1.156e-02	-4.46	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	4	16828	49	PTPRZ1,GLIS3,FGFR3,MACF1
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.160e-02	-4.46	inverted	COSMIC cancer mutations	inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-benign_melanocytic_nevus-junctional	COSMIC cancer mutations	skin-benign_melanocytic_nevus-junctional	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-other-normal	COSMIC cancer mutations	urinary_tract-bladder-other-normal	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-papilloma-inverted	COSMIC cancer mutations	urinary_tract-bladder-papilloma-inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.171e-02	-4.45	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	40	16828	49	GPC5,LRIG1,SLC1A2,RORA,GLIS3,TNIK,PTPRZ1,ERBB4,BMPR1B,SOX5,CTNND2,TRPM3,RFX4,PRKG1,SLC4A4,ATP13A4,NKAIN3,FGFR3,NHSL1,FBXL7,SLC1A3,MAML2,SFXN5,LSAMP,MSI2,RYR3,NTM,ABLIM1,HIF3A,DTNA,PARD3,NPAS3,PREX2,NFIA,CDH20,MACF1,ATP1A2,ACSS1,PARD3B,SPARCL1
1.175e-02	-4.44	skeletal system development	biological process	GO:0001501	500	5	18204	50	TRPS1,FGFR3,SOX5,BMPR1B,NFIA
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	FGFR3,ERBB4
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	NFIA,TRPS1
1.179e-02	-4.44	SYNC (syncoilin, intermediate filament protein)	protein interactions	81493	64	2	19454	50	MAML2,DTNA
1.182e-02	-4.44	regulation of glucose import	biological process	GO:0046324	60	2	18204	50	SORBS1,SLC1A2
1.182e-02	-4.44	export across plasma membrane	biological process	GO:0140115	60	2	18204	50	SLC4A4,ATP1A2
1.182e-02	-4.44	regulation of smooth muscle contraction	biological process	GO:0006940	60	2	18204	50	ATP1A2,PRKG1
1.184e-02	-4.44	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	43	TRPM3
1.184e-02	-4.44	-	gene3d domains	1.20.58.1060	4	1	14470	43	MACF1
1.184e-02	-4.44	cadherin binding	molecular function	GO:0045296	335	4	18094	48	CTNNA2,CDH20,MACF1,CTNND2
1.192e-02	-4.43	chemical homeostasis	biological process	GO:0048878	914	7	18204	50	RYR3,ZBTB20,SLC1A3,ATP1A2,RORA,ATP13A4,SLC4A4
1.200e-02	-4.42	Erythroid Transcription Factor GATA-1, subunit A	gene3d domains	3.30.50.10	56	2	14470	43	TRPS1,RORA
1.223e-02	-4.40	monoatomic cation homeostasis	biological process	GO:0055080	505	5	18204	50	SLC4A4,ATP13A4,SLC1A3,ATP1A2,RYR3
1.224e-02	-4.40	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	2	10285	31	ATP1A2,RYR3
1.228e-02	-4.40	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	6	16828	49	SPARCL1,ERBB4,BMPR1B,PRKG1,FGFR3,TNIK
1.230e-02	-4.40	KLF5 (KLF transcription factor 5)	protein interactions	688	187	3	19454	50	CLU,TRPS1,NFIA
1.230e-02	-4.40	regulation of lipid metabolic process	biological process	GO:0019216	327	4	18204	50	SORBS1,ZBTB20,PRKG1,RORA
1.240e-02	-4.39	DNA-binding transcription factor activity	molecular function	GO:0003700	1441	9	18094	48	NFIA,RORA,TRPS1,NPAS3,SOX5,GLIS3,RFX4,HIF3A,ZBTB20
1.247e-02	-4.38	IGc2	smart domains	SM00408	239	4	9717	37	LSAMP,FGFR3,NTM,LRIG1
1.248e-02	-4.38	HNF1B (HNF1 homeobox B)	protein interactions	6928	188	3	19454	50	NFIA,TRPS1,SOX5
1.250e-02	-4.38	MAML1 (mastermind like transcriptional coactivator 1)	protein interactions	9794	66	2	19454	50	NFIA,MAML2
1.250e-02	-4.38	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	2	19454	50	SFXN5,CLU
1.250e-02	-4.38	ORM1 (orosomucoid 1)	protein interactions	5004	66	2	19454	50	CLU,PTGDS
1.252e-02	-4.38	circulatory system process	biological process	GO:0003013	508	5	18204	50	SLC4A4,SLC1A3,ATP1A2,PRKG1,SLC1A2
1.259e-02	-4.38	regulation of carbohydrate catabolic process	biological process	GO:0043470	62	2	18204	50	SLC4A4,ZBTB20
1.262e-02	-4.37	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	6	16828	49	ERBB4,BMPR1B,SPARCL1,PRKG1,TNIK,FGFR3
1.276e-02	-4.36	neurofibrillary tangle	cellular component	GO:0097418	5	1	19108	49	CLU
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	PPP1R17 (protein phosphatase 1 regulatory subunit 17)	protein interactions	10842	5	1	19454	50	PRKG1
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	NRG2 (neuregulin 2)	protein interactions	9542	5	1	19454	50	ERBB4
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	EPPIN (epididymal peptidase inhibitor)	protein interactions	57119	5	1	19454	50	CLU
1.279e-02	-4.36	ADCYAP1R1 (ADCYAP receptor type I)	protein interactions	117	5	1	19454	50	CLU
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	PTGER2 (prostaglandin E receptor 2)	protein interactions	5732	5	1	19454	50	PTGDS
1.279e-02	-4.36	Hk3 (hexokinase 3)	protein interactions	25060	5	1	19454	50	PTGDS
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	SFXN5,MAML2,PITPNC1,PTGDS,LSAMP,HIF3A,ABLIM1,NTM,ZBTB20,NPAS3,PARD3,PREX2,TRPS1,GPC5,LRIG1,RORA,TNIK,GLIS3,CST3,PTPRZ1,ERBB4,CTNND2,SOX5,PRKG1,RFX4,ATP13A4,FGFR3,NKAIN3,NHSL1,SLC1A3,RYR3,MSI2,NFIA,CDH20,MACF1,ATP1A2,GPM6A,ACSS1,SPARCL1,PARD3B,CLU,SLC1A2,SORBS1,ZNRF3,BMPR1B,TRPM3,SLC4A4,FBXL7
1.309e-02	-4.34	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	31	ATP1A2,ATP13A4
1.313e-02	-4.33	Kinase-like_dom_sf	interpro domains	IPR011009	523	5	18521	50	BMPR1B,ERBB4,PRKG1,TNIK,FGFR3
1.314e-02	-4.33	inorganic ion transmembrane transport	biological process	GO:0098660	715	6	18204	50	GPM6A,ATP1A2,SLC1A3,RYR3,TRPM3,SLC4A4
1.317e-02	-4.33	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	3	18094	48	SLC1A2,SLC1A3,SFXN5
1.318e-02	-4.33	main axon	cellular component	GO:0044304	68	2	19108	49	SLC1A2,PARD3
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.320e-02	-4.33	fibroblast growth factor receptor activity	molecular function	GO:0005007	5	1	18094	48	FGFR3
1.322e-02	-4.33	monoatomic ion homeostasis	biological process	GO:0050801	515	5	18204	50	SLC1A3,ATP1A2,ATP13A4,SLC4A4,RYR3
1.323e-02	-4.33	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	4	19454	50	SORBS1,PARD3,MACF1,TNIK
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A2,SLC1A3
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.336e-02	-4.32	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	3	18094	48	SLC1A3,SFXN5,SLC1A2
1.339e-02	-4.31	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	43	16828	49	TRPS1,PREX2,NPAS3,PARD3,ZBTB20,NTM,ABLIM1,HIF3A,LSAMP,PITPNC1,SFXN5,MAML2,SLC1A3,NHSL1,NKAIN3,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,ERBB4,PTPRZ1,GLIS3,TNIK,RORA,LRIG1,GPC5,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,NFIA,RYR3,FBXL7,TRPM3,BMPR1B,SORBS1,SLC1A2,CLU
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	Mtc	interpro domains	IPR004686	5	1	18521	50	SFXN5
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.359e-02	-4.30	Axon guidance	KEGG pathways	ko04360	174	3	7161	21	PARD3,BMPR1B,ABLIM1
1.359e-02	-4.30	Axon guidance	KEGG pathways	hsa04360	174	3	7161	21	ABLIM1,BMPR1B,PARD3
1.363e-02	-4.30	temporoparietal	COSMIC cancer mutations	temporoparietal	61	2	16828	49	RYR3,PARD3
1.366e-02	-4.29	stem cell differentiation	biological process	GO:0048863	182	3	18204	50	MSI2,ERBB4,GPM6A
1.366e-02	-4.29	otolith morphogenesis	biological process	GO:0032474	5	1	18204	50	LRIG1
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	tricarboxylic acid transport	biological process	GO:0006842	5	1	18204	50	SFXN5
1.366e-02	-4.29	propionate metabolic process	biological process	GO:0019541	5	1	18204	50	ACSS1
1.366e-02	-4.29	ERBB2-ERBB4 signaling pathway	biological process	GO:0038135	5	1	18204	50	ERBB4
1.366e-02	-4.29	positive regulation of amyloid fibril formation	biological process	GO:1905908	5	1	18204	50	CLU
1.366e-02	-4.29	negative regulation of glutamate secretion	biological process	GO:0014050	5	1	18204	50	PRKG1
1.366e-02	-4.29	citrate transport	biological process	GO:0015746	5	1	18204	50	SFXN5
1.366e-02	-4.29	central nervous system myelin maintenance	biological process	GO:0032286	5	1	18204	50	CLU
1.366e-02	-4.29	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	50	BMPR1B
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	CST3,PTPRZ1,ERBB4,GPC5,LRIG1,RORA,GLIS3,TNIK,NHSL1,SLC1A3,CTNND2,SOX5,PRKG1,RFX4,ATP13A4,FGFR3,NKAIN3,HIF3A,ABLIM1,NTM,DTNA,ZBTB20,NPAS3,PARD3,SFXN5,MAML2,PTGDS,LSAMP,TRPS1,PREX2,SORBS1,ZNRF3,BMPR1B,CLU,SLC1A2,FBXL7,TRPM3,SLC4A4,RYR3,MSI2,ATP1A2,GPM6A,ACSS1,SPARCL1,PARD3B,NFIA,CDH20,MACF1
1.375e-02	-4.29	skin-upper_back-malignant_melanoma	COSMIC cancer mutations	skin-upper_back-malignant_melanoma	319	4	16828	49	GPC5,PARD3B,ERBB4,MACF1
1.377e-02	-4.29	apoptotic mitochondrial changes	biological process	GO:0008637	65	2	18204	50	CLU,ERBB4
1.386e-02	-4.28	PDZ	prosite domains	PS50106	143	3	12186	43	PARD3,PARD3B,PREX2
1.389e-02	-4.28	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	50	CTNND2,ZNRF3,MACF1,GPC5
1.390e-02	-4.28	cellular component organization or biogenesis	biological process	GO:0071840	5850	24	18204	50	BMPR1B,TRPM3,TNIK,PTPRZ1,CLU,MACF1,CTNNA2,RYR3,GPM6A,SORBS1,PITPNC1,SLC1A2,ERBB4,PARD3,CST3,PRKG1,CDH20,PARD3B,PREX2,SPARCL1,NFIA,CTNND2,ABLIM1,RFX4
1.392e-02	-4.27	extracellular matrix	cellular component	GO:0031012	559	5	19108	49	LRIG1,PTPRZ1,CLU,GPC5,SPARCL1
1.397e-02	-4.27	FOLN	pfam domains	PF09289	5	1	17795	50	SPARCL1
1.397e-02	-4.27	IP_trans	pfam domains	PF02121	5	1	17795	50	PITPNC1
1.397e-02	-4.27	SFXNs	pfam domains	PF03820	5	1	17795	50	SFXN5
1.397e-02	-4.27	Vinculin	pfam domains	PF01044	5	1	17795	50	CTNNA2
1.397e-02	-4.27	VHL (von Hippel-Lindau tumor suppressor)	protein interactions	7428	558	5	19454	50	PRKG1,HIF3A,CLU,PARD3,FGFR3
1.399e-02	-4.27	MTMR9 (myotubularin related protein 9)	protein interactions	66036	70	2	19454	50	CLU,ERBB4
1.402e-02	-4.27	external encapsulating structure	cellular component	GO:0030312	560	5	19108	49	SPARCL1,GPC5,CLU,PTPRZ1,LRIG1
1.404e-02	-4.27	CTF_NFI_1	prosite domains	PS00349	4	1	12186	43	NFIA
1.404e-02	-4.27	CTF_NFI_2	prosite domains	PS51080	4	1	12186	43	NFIA
1.408e-02	-4.26	cell population proliferation	biological process	GO:0008283	726	6	18204	50	NFIA,FGFR3,SOX5,CLU,ZNRF3,RORA
1.412e-02	-4.26	membrane protein complex	cellular component	GO:0098796	1261	8	19108	49	RYR3,BMPR1B,CTNNA2,SLC1A3,SORBS1,ATP1A2,CDH20,SLC1A2
1.413e-02	-4.26	lower_leg	COSMIC cancer mutations	lower_leg	174	3	16828	49	PREX2,ERBB4,FGFR3
1.418e-02	-4.26	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	49	RFX4,PRKG1,SOX5,CTNND2,NKAIN3,FGFR3,ATP13A4,NHSL1,SLC1A3,GPC5,TNIK,GLIS3,LRIG1,RORA,PTPRZ1,CST3,ERBB4,PREX2,TRPS1,PTGDS,PITPNC1,MAML2,SFXN5,LSAMP,DTNA,ABLIM1,NTM,HIF3A,PARD3,NPAS3,ZBTB20,TRPM3,SLC4A4,FBXL7,CLU,SLC1A2,SORBS1,BMPR1B,ZNRF3,NFIA,MACF1,CDH20,ACSS1,GPM6A,ATP1A2,PARD3B,SPARCL1,RYR3
1.418e-02	-4.26	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	49	SLC1A3,NHSL1,NKAIN3,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,ERBB4,PTPRZ1,CST3,TNIK,GLIS3,RORA,LRIG1,GPC5,TRPS1,PREX2,NPAS3,PARD3,ZBTB20,DTNA,NTM,ABLIM1,HIF3A,LSAMP,PTGDS,PITPNC1,SFXN5,MAML2,FBXL7,SLC4A4,TRPM3,BMPR1B,ZNRF3,SORBS1,SLC1A2,CLU,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,NFIA,RYR3
1.418e-02	-4.26	positive regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042531	66	2	18204	50	ERBB4,FGFR3
1.418e-02	-4.26	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	50	SLC1A2,SLC1A3
1.425e-02	-4.25	DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5)	protein interactions	80331	365	4	19454	50	CLU,DTNA,PARD3,MACF1
1.427e-02	-4.25	response to growth factor	biological process	GO:0070848	525	5	18204	50	BMPR1B,FGFR3,SOX5,ERBB4,NFIA
1.433e-02	-4.25	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	4	16828	49	PARD3B,PTPRZ1,SORBS1,NTM
1.433e-02	-4.25	NFIX (nuclear factor I X)	protein interactions	4784	198	3	19454	50	SOX5,TRPS1,NFIA
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	TNIK,GPM6A
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	MACF1,PARD3
1.446e-02	-4.24	ALPHACATENIN	prints domains	PR00805	4	1	5227	19	CTNNA2
1.448e-02	-4.24	lichenoid_keratosis	COSMIC cancer mutations	lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-arm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-arm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-nevus_sebaceous	COSMIC cancer mutations	skin-shoulder-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-lichenoid_keratosis	COSMIC cancer mutations	skin-shoulder-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-adnexal_tumour-syringocystadenoma_papilliferum	COSMIC cancer mutations	skin-adnexal_tumour-syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-nevus_sebaceous	COSMIC cancer mutations	skin-neck-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hip-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-hip-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-flank-other-lichenoid_keratosis	COSMIC cancer mutations	skin-flank-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-nevus_sebaceous	COSMIC cancer mutations	skin-lower_back-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hand-other-lichenoid_keratosis	COSMIC cancer mutations	skin-hand-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_arm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_arm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-lichenoid_keratosis	COSMIC cancer mutations	skin-breast-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-lichenoid_keratosis	COSMIC cancer mutations	skin-neck-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-ear-other-nevus_sebaceous	COSMIC cancer mutations	skin-ear-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	syringocystadenoma_papilliferum	COSMIC cancer mutations	syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-forearm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-forearm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-lichenoid_keratosis	COSMIC cancer mutations	skin-face-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-other-lichenoid_keratosis	COSMIC cancer mutations	skin-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.448e-02	-4.24	skin-breast-other-nevus_sebaceous	COSMIC cancer mutations	skin-breast-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-nevus_sebaceous	COSMIC cancer mutations	skin-face-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-chest-other-lichenoid_keratosis	COSMIC cancer mutations	skin-chest-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-scalp-other-nevus_sebaceous	COSMIC cancer mutations	skin-scalp-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.451e-02	-4.23	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	50	CLU,ABLIM1,TNIK,PARD3
1.456e-02	-4.23	Transferase(Phosphotransferase) domain 1	gene3d domains	1.10.510.10	490	5	14470	43	BMPR1B,ERBB4,FGFR3,TNIK,PRKG1
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	GPM6A,TNIK
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	BMPR1B,PARD3B
1.476e-02	-4.22	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	50	ABLIM1,PARD3
1.500e-02	-4.20	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	8	16828	49	ERBB4,RYR3,RORA,FGFR3,TNIK,MAML2,CTNND2,PRKG1
1.501e-02	-4.20	lung-carcinoid-endocrine_tumour	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour	502	5	16828	49	PRKG1,FGFR3,TNIK,BMPR1B,ERBB4
1.510e-02	-4.19	regulation of lipid biosynthetic process	biological process	GO:0046890	189	3	18204	50	PRKG1,SORBS1,ZBTB20
1.512e-02	-4.19	FEV (FEV transcription factor, ETS family member)	protein interactions	54738	202	3	19454	50	NFIA,TRPS1,SOX5
1.520e-02	-4.19	ORF3a (ORF3a protein)	protein interactions	43740569	789	6	19454	50	CLU,PARD3B,BMPR1B,ZNRF3,SLC4A4,PARD3
1.529e-02	-4.18	PAR polarity complex	cellular component	GO:0120157	6	1	19108	49	PARD3
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	Taok2 (TAO kinase 2)	protein interactions	381921	6	1	19454	50	CLU
1.532e-02	-4.18	FGF23 (fibroblast growth factor 23)	protein interactions	8074	6	1	19454	50	FGFR3
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	RSPO3 (R-spondin 3)	protein interactions	84870	6	1	19454	50	ZNRF3
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	FGF6 (fibroblast growth factor 6)	protein interactions	2251	6	1	19454	50	FGFR3
1.532e-02	-4.18	FGF18 (fibroblast growth factor 18)	protein interactions	8817	6	1	19454	50	FGFR3
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	NRG4 (neuregulin 4)	protein interactions	145957	6	1	19454	50	ERBB4
1.539e-02	-4.17	skin-ankle-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-ankle-malignant_melanoma-acral_lentiginous	330	4	16828	49	PREX2,ATP13A4,PARD3,ERBB4
1.541e-02	-4.17	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	5	19454	50	DTNA,TNIK,ERBB4,MACF1,PARD3
1.549e-02	-4.17	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	5	16828	49	PRKG1,ZBTB20,NPAS3,SPARCL1,FGFR3
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	ABLIM1,DTNA,PARD3B
1.552e-02	-4.17	NFIC (nuclear factor I C)	protein interactions	4782	204	3	19454	50	NFIA,SOX5,TRPS1
1.554e-02	-4.16	TEC (tec protein tyrosine kinase)	protein interactions	7006	74	2	19454	50	MSI2,ERBB4
1.555e-02	-4.16	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	4	16828	49	PTPRZ1,SORBS1,NTM,PARD3B
1.572e-02	-4.15	UTRN (utrophin)	protein interactions	7402	205	3	19454	50	PARD3,FGFR3,DTNA
1.573e-02	-4.15	lung-carcinoid-endocrine_tumour-atypical	COSMIC cancer mutations	lung-carcinoid-endocrine_tumour-atypical	508	5	16828	49	FGFR3,BMPR1B,TNIK,ERBB4,PRKG1
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.595e-02	-4.14	cell projection	cellular component	GO:0042995	2398	12	19108	49	CTNND2,SLC1A3,MACF1,CLU,ATP1A2,ABLIM1,PARD3,BMPR1B,CTNNA2,DTNA,GPM6A,SLC1A2
1.597e-02	-4.14	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	20	ATP1A2,SLC1A3
1.598e-02	-4.14	cell adhesion molecule binding	molecular function	GO:0050839	560	5	18094	48	PTPRZ1,CTNNA2,CDH20,CTNND2,MACF1
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	TRPS1,PREX2,ZBTB20,PARD3,NPAS3,HIF3A,NTM,ABLIM1,DTNA,LSAMP,SFXN5,MAML2,PTGDS,SLC1A3,NHSL1,ATP13A4,FGFR3,NKAIN3,CTNND2,SOX5,PRKG1,RFX4,ERBB4,CST3,PTPRZ1,LRIG1,RORA,GLIS3,TNIK,GPC5,SPARCL1,PARD3B,ATP1A2,GPM6A,ACSS1,CDH20,MACF1,NFIA,RYR3,MSI2,FBXL7,SLC4A4,TRPM3,ZNRF3,BMPR1B,SORBS1,SLC1A2,CLU
1.600e-02	-4.13	PDGFRA (platelet derived growth factor receptor alpha)	protein interactions	5156	378	4	19454	50	LRIG1,FGFR3,CLU,DTNA
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	GF_recep_IV	interpro domains	IPR032778	6	1	18521	50	ERBB4
1.609e-02	-4.13	GLI-like	interpro domains	IPR043359	6	1	18521	50	GLIS3
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.618e-02	-4.12	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	14	16828	49	SOX5,CTNND2,PREX2,ATP13A4,CDH20,ATP1A2,SLC1A3,TRPS1,MAML2,LSAMP,RYR3,PTPRZ1,ERBB4,PARD3
1.622e-02	-4.12	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	8	16828	49	ERBB4,TNIK,FGFR3,RORA,RYR3,PRKG1,CTNND2,MAML2
1.625e-02	-4.12	Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME pathways	R-HSA-2219530	65	2	10285	31	ERBB4,FGFR3
1.633e-02	-4.11	BCL2L1 (BCL2 like 1)	protein interactions	598	208	3	19454	50	RYR3,ABLIM1,CLU
1.637e-02	-4.11	negative regulation of extracellular matrix disassembly	biological process	GO:0010716	6	1	18204	50	CST3
1.637e-02	-4.11	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	50	SLC1A3
1.637e-02	-4.11	protein targeting to vacuole involved in autophagy	biological process	GO:0071211	6	1	18204	50	CLU
1.637e-02	-4.11	fused antrum stage	biological process	GO:0048165	6	1	18204	50	BMPR1B
1.637e-02	-4.11	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	50	ERBB4
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	relaxation of vascular associated smooth muscle	biological process	GO:0060087	6	1	18204	50	PRKG1
1.660e-02	-4.10	atypical	COSMIC cancer mutations	atypical	515	5	16828	49	FGFR3,ERBB4,BMPR1B,TNIK,PRKG1
1.672e-02	-4.09	regulation of ATP metabolic process	biological process	GO:1903578	72	2	18204	50	SLC4A4,ZBTB20
1.674e-02	-4.09	Plectin	pfam domains	PF00681	6	1	17795	50	MACF1
1.674e-02	-4.09	GF_recep_IV	pfam domains	PF14843	6	1	17795	50	ERBB4
1.674e-02	-4.09	SH3_10	pfam domains	PF17902	6	1	17795	50	MACF1
1.674e-02	-4.09	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	50	RYR3
1.674e-02	-4.09	RYDR_ITPR	pfam domains	PF01365	6	1	17795	50	RYR3
1.674e-02	-4.09	RIH_assoc	pfam domains	PF08454	6	1	17795	50	RYR3
1.674e-02	-4.09	GAS2	pfam domains	PF02187	6	1	17795	50	MACF1
1.674e-02	-4.09	EF-hand_2	pfam domains	PF09068	6	1	17795	50	DTNA
1.674e-02	-4.09	Glypican	pfam domains	PF01153	6	1	17795	50	GPC5
1.674e-02	-4.09	EF-hand_3	pfam domains	PF09069	6	1	17795	50	DTNA
1.675e-02	-4.09	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	50	SORBS1,NHSL1,SLC1A3
1.683e-02	-4.08	PDZ	smart domains	SM00228	143	3	9717	37	PREX2,PARD3B,PARD3
1.694e-02	-4.08	signal transduction	biological process	GO:0007165	4637	20	18204	50	ZNRF3,SORBS1,PITPNC1,DTNA,CTNND2,RORA,ATP1A2,NFIA,RYR3,FGFR3,SPARCL1,MACF1,CLU,MAML2,PREX2,PRKG1,BMPR1B,ERBB4,PARD3,TNIK
1.696e-02	-4.08	CDK6 (cyclin dependent kinase 6)	protein interactions	1021	211	3	19454	50	FGFR3,SORBS1,SOX5
1.701e-02	-4.07	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	9	16828	49	ATP1A2,PARD3B,ERBB4,CTNND2,TRPM3,MACF1,FGFR3,RYR3,ATP13A4
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP1A2,ATP13A4
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.715e-02	-4.07	extremity	COSMIC cancer mutations	extremity	1876	11	16828	49	PREX2,ATP13A4,CDH20,FGFR3,FBXL7,ACSS1,PITPNC1,RYR3,PTPRZ1,ERBB4,PARD3
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	SOX5,MSI2
1.717e-02	-4.06	regulation of multicellular organismal process	biological process	GO:0051239	3113	15	18204	50	MACF1,SFXN5,PTGDS,TRPS1,ATP1A2,RORA,ZBTB20,BMPR1B,SOX5,ERBB4,PARD3,PRKG1,CST3,PTPRZ1,CLU
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-adnexal_tumour-trichoblastoma	COSMIC cancer mutations	skin-adnexal_tumour-trichoblastoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_leg-epidermal_nevus	COSMIC cancer mutations	skin-lower_leg-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-lower_back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-upper_leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-upper_leg-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-abdomen-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-abdomen-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-flank-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-flank-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	kidney-carcinoma-collecting_duct_carcinoma	COSMIC cancer mutations	kidney-carcinoma-collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-actinic_keratosis	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-actinic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-epidermal_nevus	COSMIC cancer mutations	skin-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-Bowen_disease	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-Bowen_disease	6	1	16828	49	FGFR3
1.735e-02	-4.05	lentiginous_nevus	COSMIC cancer mutations	lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-face-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-face-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-arm-epidermal_nevus	COSMIC cancer mutations	skin-arm-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-epidermal_nevus	COSMIC cancer mutations	skin-head_neck-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.735e-02	-4.05	skin-trunk-epidermal_nevus	COSMIC cancer mutations	skin-trunk-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	collecting_duct_carcinoma	COSMIC cancer mutations	collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-benign_melanocytic_nevus-lentiginous_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus-lentiginous_nevus	6	1	16828	49	FGFR3
1.759e-02	-4.04	PRDM1 (PR/SET domain 1)	protein interactions	639	79	2	19454	50	NFIA,TRPS1
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	NHSL1,TNIK,ERBB4
1.765e-02	-4.04	animal organ morphogenesis	biological process	GO:0009887	988	7	18204	50	ERBB4,SOX5,BMPR1B,FGFR3,CTNNA2,LRIG1,ABLIM1
1.766e-02	-4.04	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	19	16828	49	ACSS1,ATP1A2,PARD3B,TRPS1,PREX2,RFX4,CTNND2,MACF1,FGFR3,ATP13A4,SLC4A4,CDH20,ABLIM1,PARD3,ERBB4,GPC5,LRIG1,RORA,SLC1A2
1.770e-02	-4.03	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	43	MACF1
1.770e-02	-4.03	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	43	MACF1
1.770e-02	-4.03	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	43	RYR3
1.770e-02	-4.03	Single helix bin	gene3d domains	1.20.5.490	6	1	14470	43	PRKG1
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	C7 (complement C7)	protein interactions	730	7	1	19454	50	CLU
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	CYP4F8 (cytochrome P450 family 4 subfamily F member 8)	protein interactions	11283	7	1	19454	50	CLU
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SOAT2 (sterol O-acyltransferase 2)	protein interactions	8435	7	1	19454	50	CLU
1.786e-02	-4.03	C8B (complement C8 beta chain)	protein interactions	732	7	1	19454	50	CLU
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	FGF5 (fibroblast growth factor 5)	protein interactions	2250	7	1	19454	50	FGFR3
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.795e-02	-4.02	protein kinase activity	molecular function	GO:0004672	577	5	18094	48	PRKG1,FGFR3,TNIK,ERBB4,BMPR1B
1.802e-02	-4.02	Bile secretion	KEGG pathways	ko04976	71	2	7161	21	SLC4A4,ATP1A2
1.802e-02	-4.02	Bile secretion	KEGG pathways	hsa04976	71	2	7161	21	SLC4A4,ATP1A2
1.805e-02	-4.01	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	19	SLC4A4
1.805e-02	-4.01	PITRANSFER	prints domains	PR00391	5	1	5227	19	PITPNC1
1.826e-02	-4.00	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	3	19454	50	NKAIN3,ABLIM1,RORA
1.836e-02	-4.00	plasma membrane protein complex	cellular component	GO:0098797	600	5	19108	49	CDH20,ATP1A2,BMPR1B,CTNNA2,SORBS1
1.838e-02	-4.00	animal organ development	biological process	GO:0048513	2846	14	18204	50	BMPR1B,ERBB4,SOX5,PRKG1,RORA,GPM6A,ATP1A2,SLC1A2,ABLIM1,RFX4,FGFR3,LRIG1,CTNNA2,NFIA
1.840e-02	-4.00	actin filament binding	molecular function	GO:0051015	211	3	18094	48	CTNNA2,ABLIM1,MACF1
1.843e-02	-3.99	mitogen-activated protein kinase p38 binding	molecular function	GO:0048273	7	1	18094	48	PRKG1
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	SOX17 (SRY-box transcription factor 17)	protein interactions	64321	81	2	19454	50	NFIA,TRPS1
1.852e-02	-3.99	regulation of tyrosine phosphorylation of STAT protein	biological process	GO:0042509	76	2	18204	50	ERBB4,FGFR3
1.871e-02	-3.98	positive regulation of biological process	biological process	GO:0048518	6326	25	18204	50	SLC1A3,SLC4A4,ERBB4,PARD3,SOX5,NPAS3,PRKG1,GLIS3,ATP1A2,GPC5,RORA,RFX4,FGFR3,NFIA,PTPRZ1,MAML2,CLU,TNIK,BMPR1B,GPM6A,SLC1A2,ZBTB20,SORBS1,MACF1,SFXN5
1.872e-02	-3.98	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	50	RYR3,GPM6A,TRPM3
1.875e-02	-3.98	Rcpt_L-dom	interpro domains	IPR000494	7	1	18521	50	ERBB4
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	Furin-like_Cys-rich_dom	interpro domains	IPR006211	7	1	18521	50	ERBB4
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	Rcpt_L-dom_sf	interpro domains	IPR036941	7	1	18521	50	ERBB4
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP13A4,ATP1A2
1.886e-02	-3.97	TNNT1 (troponin T1, slow skeletal type)	protein interactions	7138	82	2	19454	50	BMPR1B,PRKG1
1.889e-02	-3.97	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	47	16828	49	FBXL7,TRPM3,SLC4A4,SORBS1,BMPR1B,ZNRF3,CLU,SLC1A2,ACSS1,GPM6A,ATP1A2,PARD3B,SPARCL1,NFIA,MACF1,CDH20,RYR3,MSI2,NHSL1,SLC1A3,RFX4,PRKG1,SOX5,CTNND2,NKAIN3,FGFR3,ATP13A4,PTPRZ1,ERBB4,GPC5,GLIS3,TNIK,RORA,LRIG1,TRPS1,PREX2,DTNA,ABLIM1,NTM,HIF3A,NPAS3,PARD3,ZBTB20,PITPNC1,MAML2,SFXN5,LSAMP
1.891e-02	-3.97	system process	biological process	GO:0003008	2015	11	18204	50	DTNA,ABLIM1,SLC1A2,ATP1A2,RYR3,CTNNA2,LRIG1,PTPRZ1,SLC1A3,PRKG1,SLC4A4
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.898e-02	-3.96	regulation of organic acid transport	biological process	GO:0032890	77	2	18204	50	PRKG1,ATP1A2
1.898e-02	-3.96	BMP signaling pathway	biological process	GO:0030509	77	2	18204	50	NFIA,BMPR1B
1.907e-02	-3.96	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	50	PTPRZ1
1.907e-02	-3.96	chaperone-mediated autophagy	biological process	GO:0061684	7	1	18204	50	CLU
1.907e-02	-3.96	glial cell fate specification	biological process	GO:0021780	7	1	18204	50	NFIA
1.907e-02	-3.96	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	50	CTNNA2
1.907e-02	-3.96	relaxation of smooth muscle	biological process	GO:0044557	7	1	18204	50	PRKG1
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	regulation of testosterone biosynthetic process	biological process	GO:2000224	7	1	18204	50	PRKG1
1.907e-02	-3.96	regulation of male germ cell proliferation	biological process	GO:2000254	7	1	18204	50	PTGDS
1.907e-02	-3.96	positive regulation of transcription of Notch receptor target	biological process	GO:0007221	7	1	18204	50	MAML2
1.907e-02	-3.96	negative regulation of non-canonical Wnt signaling pathway	biological process	GO:2000051	7	1	18204	50	ZNRF3
1.914e-02	-3.96	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	49	MACF1,FGFR3
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	ATP1A2,SORBS1
1.929e-02	-3.95	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	15	16828	49	NPAS3,PARD3,BMPR1B,ERBB4,HIF3A,NTM,MSI2,MAML2,SPARCL1,ATP1A2,SLC4A4,MACF1,FGFR3,TRPM3,PRKG1
1.929e-02	-3.95	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	15	16828	49	MSI2,MAML2,NPAS3,PARD3,BMPR1B,ERBB4,HIF3A,NTM,SLC4A4,FGFR3,MACF1,TRPM3,PRKG1,SPARCL1,ATP1A2
1.930e-02	-3.95	DNM3 (dynamin 3)	protein interactions	26052	83	2	19454	50	GPM6A,FGFR3
1.930e-02	-3.95	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	50	NFIA,TRPS1
1.943e-02	-3.94	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	MACF1,PARD3,ATP13A4,SLC1A2,PREX2,GPC5,TRPM3
1.943e-02	-3.94	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	PREX2,GPC5,TRPM3,PARD3,MACF1,SLC1A2,ATP13A4
1.944e-02	-3.94	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	50	SORBS1,SLC1A2
1.944e-02	-3.94	dicarboxylic acid transport	biological process	GO:0006835	78	2	18204	50	SLC1A3,SLC1A2
1.951e-02	-3.94	Recep_L_domain	pfam domains	PF01030	7	1	17795	50	ERBB4
1.951e-02	-3.94	Furin-like	pfam domains	PF00757	7	1	17795	50	ERBB4
1.951e-02	-3.94	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	50	SPARCL1
1.951e-02	-3.94	TGF_beta_GS	pfam domains	PF08515	7	1	17795	50	BMPR1B
1.964e-02	-3.93	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	49	MACF1,FGFR3
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	ERBB4,FGFR3
1.978e-02	-3.92	cytoskeleton organization	biological process	GO:0007010	1251	8	18204	50	MACF1,CTNNA2,TNIK,PARD3,PRKG1,PARD3B,ABLIM1,SORBS1
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	ABLIM1,MACF1,GPM6A
2.002e-02	-3.91	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	7	19454	50	PARD3B,NHSL1,ABLIM1,PITPNC1,SORBS1,MACF1,PARD3
2.004e-02	-3.91	somatodendritic compartment	cellular component	GO:0036477	842	6	19108	49	ATP1A2,BMPR1B,CTNND2,SLC1A3,CLU,GPM6A
2.008e-02	-3.91	KLF3 (KLF transcription factor 3)	protein interactions	51274	225	3	19454	50	SOX5,TRPS1,NFIA
2.020e-02	-3.90	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	8	19454	50	CLU,TRPS1,LSAMP,MSI2,MACF1,NFIA,SOX5,GLIS3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-intradermal	COSMIC cancer mutations	skin-benign_melanocytic_nevus-intradermal	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-other-nevus_sebaceous	COSMIC cancer mutations	skin-other-nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	urinary_tract-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma-transitional_cell_carcinoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-face-adnexal_tumour-malignant_adnexal_tumour	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-adnexal_tumour-trichilemmoma	COSMIC cancer mutations	skin-adnexal_tumour-trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-shoulder-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-shoulder-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	nevus_sebaceous	COSMIC cancer mutations	nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-chest-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-chest-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	trichilemmoma	COSMIC cancer mutations	trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-compound	COSMIC cancer mutations	skin-benign_melanocytic_nevus-compound	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-neck-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-neck-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.034e-02	-3.90	spherical high-density lipoprotein particle	cellular component	GO:0034366	8	1	19108	49	CLU
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.035e-02	-3.89	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	43	ATP1A2,ATP13A4
2.038e-02	-3.89	Chmp2a (charged multivesicular body protein 2A)	protein interactions	68953	8	1	19454	50	CLU
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	PTGER1 (prostaglandin E receptor 1)	protein interactions	5731	8	1	19454	50	PTGDS
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.044e-02	-3.89	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	25	16828	49	ERBB4,PTPRZ1,CST3,GLIS3,LRIG1,RORA,SLC1A3,NKAIN3,FGFR3,ATP13A4,SLC4A4,SOX5,TRPM3,CTNND2,NPAS3,PARD3,ZBTB20,DTNA,ABLIM1,RYR3,MAML2,SPARCL1,ATP1A2,MACF1,PREX2
2.053e-02	-3.89	stress fiber	cellular component	GO:0001725	86	2	19108	49	SORBS1,ABLIM1
2.053e-02	-3.89	contractile actin filament bundle	cellular component	GO:0097517	86	2	19108	49	ABLIM1,SORBS1
2.062e-02	-3.88	Receptor L-domain	gene3d domains	3.80.20.20	7	1	14470	43	ERBB4
2.063e-02	-3.88	EGLN1 (egl-9 family hypoxia inducible factor 1)	protein interactions	54583	86	2	19454	50	FGFR3,HIF3A
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	GPM6A,SORBS1
2.067e-02	-3.88	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	5	16828	49	BMPR1B,ERBB4,TNIK,FGFR3,PRKG1
2.082e-02	-3.87	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	5	16828	49	PRKG1,FGFR3,TNIK,ERBB4,BMPR1B
2.084e-02	-3.87	dendrite	cellular component	GO:0030425	620	5	19108	49	ATP1A2,BMPR1B,CTNND2,CLU,GPM6A
2.087e-02	-3.87	adult locomotory behavior	biological process	GO:0008344	81	2	18204	50	ATP1A2,PREX2
2.091e-02	-3.87	FGFR3b ligand binding and activation	REACTOME pathways	R-HSA-190371	7	1	10285	31	FGFR3
2.099e-02	-3.86	GAR	prosite domains	PS51460	6	1	12186	43	MACF1
2.099e-02	-3.86	GLYPICAN	prosite domains	PS01207	6	1	12186	43	GPC5
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	MACF1,SPARCL1,RYR3
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.103e-02	-3.86	cyclic nucleotide-dependent protein kinase activity	molecular function	GO:0004690	8	1	18094	48	PRKG1
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.106e-02	-3.86	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	4	16828	49	MACF1,CTNND2,TRPM3,PREX2
2.108e-02	-3.86	NHLH1 (nescient helix-loop-helix 1)	protein interactions	4807	87	2	19454	50	TRPS1,NFIA
2.108e-02	-3.86	Kctd5 (potassium channel tetramerisation domain containing 5)	protein interactions	69259	87	2	19454	50	TRPS1,SLC1A3
2.108e-02	-3.86	ZNF608 (zinc finger protein 608)	protein interactions	57507	87	2	19454	50	SOX5,NFIA
2.110e-02	-3.86	dendritic tree	cellular component	GO:0097447	622	5	19108	49	CTNND2,BMPR1B,ATP1A2,GPM6A,CLU
2.111e-02	-3.86	anion binding	molecular function	GO:0043168	2412	12	18094	48	ACSS1,PARD3,ATP13A4,FGFR3,ATP1A2,PTGDS,BMPR1B,ERBB4,SLC1A3,PRKG1,TNIK,PITPNC1
2.123e-02	-3.85	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	46	16828	49	MSI2,RYR3,SPARCL1,PARD3B,ACSS1,ATP1A2,GPM6A,MACF1,CDH20,NFIA,ZNRF3,BMPR1B,SORBS1,SLC1A2,CLU,FBXL7,SLC4A4,TRPM3,NPAS3,PARD3,ZBTB20,DTNA,HIF3A,ABLIM1,LSAMP,PTGDS,PITPNC1,MAML2,SFXN5,TRPS1,PREX2,ERBB4,PTPRZ1,TNIK,GLIS3,RORA,LRIG1,GPC5,SLC1A3,NHSL1,FGFR3,NKAIN3,ATP13A4,PRKG1,CTNND2,SOX5
2.123e-02	-3.85	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	46	16828	49	SLC4A4,TRPM3,FBXL7,SLC1A2,CLU,BMPR1B,ZNRF3,SORBS1,MACF1,CDH20,NFIA,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MSI2,RYR3,NKAIN3,FGFR3,ATP13A4,PRKG1,SOX5,CTNND2,SLC1A3,NHSL1,TNIK,GLIS3,RORA,LRIG1,GPC5,ERBB4,PTPRZ1,PREX2,TRPS1,LSAMP,PTGDS,PITPNC1,MAML2,SFXN5,NPAS3,PARD3,ZBTB20,DTNA,ABLIM1,HIF3A
2.127e-02	-3.85	DST (dystonin)	protein interactions	667	230	3	19454	50	TNIK,ATP1A2,PARD3
2.128e-02	-3.85	mesothelioma	COSMIC cancer mutations	mesothelioma	4477	20	16828	49	ZNRF3,ERBB4,BMPR1B,HIF3A,PTPRZ1,MSI2,RORA,LRIG1,TNIK,MAML2,PITPNC1,CLU,TRPS1,FBXL7,ATP13A4,FGFR3,CTNND2,SOX5,PRKG1,PREX2
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	TNIK,BMPR1B
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	NTM,FGFR3,LSAMP,LRIG1
2.162e-02	-3.83	ACTIVIN2R	prints domains	PR00653	6	1	5227	19	BMPR1B
2.174e-02	-3.83	EGFR (epidermal growth factor receptor)	protein interactions	1956	3105	14	19454	50	PARD3,TNIK,TRPM3,SPARCL1,ERBB4,CTNNA2,CTNND2,CLU,LRIG1,SORBS1,ABLIM1,TRPS1,DTNA,PTGDS
2.177e-02	-3.83	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	50	ERBB4
2.177e-02	-3.83	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	50	RORA
2.177e-02	-3.83	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	50	CTNNA2
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.177e-02	-3.83	regulation of germ cell proliferation	biological process	GO:1905936	8	1	18204	50	PTGDS
2.177e-02	-3.83	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	50	RORA
2.177e-02	-3.83	protein import	biological process	GO:0017038	8	1	18204	50	CLU
2.177e-02	-3.83	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	50	SLC1A3
2.177e-02	-3.83	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	50	RORA
2.184e-02	-3.82	regulation of amine transport	biological process	GO:0051952	83	2	18204	50	PRKG1,ATP1A2
2.199e-02	-3.82	SOX10 (SRY-box transcription factor 10)	protein interactions	6663	89	2	19454	50	TRPS1,NFIA
2.224e-02	-3.81	HMG20A (high mobility group 20A)	protein interactions	10363	234	3	19454	50	SOX5,DTNA,NFIA
2.226e-02	-3.80	VHP	pfam domains	PF02209	8	1	17795	50	ABLIM1
2.226e-02	-3.80	LSDAT_euk	pfam domains	PF18139	8	1	17795	50	TRPM3
2.233e-02	-3.80	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	50	ATP1A2,NKAIN3
2.233e-02	-3.80	L-amino acid transport	biological process	GO:0015807	84	2	18204	50	SLC1A2,SLC1A3
2.233e-02	-3.80	stem cell development	biological process	GO:0048864	84	2	18204	50	MSI2,ERBB4
2.249e-02	-3.79	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	3	19454	50	PARD3,MACF1,DTNA
2.262e-02	-3.79	thyroid	COSMIC cancer mutations	thyroid	9867	36	16828	49	CLU,GPC5,GLIS3,TNIK,RORA,SLC1A2,LRIG1,PTPRZ1,CST3,ERBB4,ZNRF3,PRKG1,SOX5,CTNND2,TRPM3,FGFR3,SLC4A4,ATP13A4,NHSL1,PTGDS,MAML2,RYR3,LSAMP,DTNA,ABLIM1,HIF3A,PARD3,NFIA,PREX2,MACF1,CDH20,ACSS1,ATP1A2,PARD3B,SPARCL1,TRPS1
2.264e-02	-3.79	GAS2	smart domains	SM00243	6	1	9717	37	MACF1
2.268e-02	-3.79	breast-carcinoma-lobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-lobular_carcinoma	763	6	16828	49	PRKG1,CDH20,FGFR3,ERBB4,BMPR1B,TNIK
2.268e-02	-3.79	lobular_carcinoma	COSMIC cancer mutations	lobular_carcinoma	763	6	16828	49	ERBB4,BMPR1B,TNIK,FGFR3,CDH20,PRKG1
2.283e-02	-3.78	oligodendrocyte differentiation	biological process	GO:0048709	85	2	18204	50	PTPRZ1,CLU
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.290e-02	-3.78	MUC4 (mucin 4, cell surface associated)	protein interactions	4585	9	1	19454	50	ERBB4
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	FGFR3
2.290e-02	-3.78	GUSBP1 (GUSB pseudogene 1)	protein interactions	728411	9	1	19454	50	FGFR3
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	SORBS1,TNIK
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	NTM,GPM6A
2.292e-02	-3.78	FOXI1 (forkhead box I1)	protein interactions	2299	91	2	19454	50	NFIA,TRPS1
2.298e-02	-3.77	Muscle contraction	REACTOME pathways	R-HSA-397014	204	3	10285	31	ATP1A2,RYR3,SORBS1
2.306e-02	-3.77	trichoblastoma	COSMIC cancer mutations	trichoblastoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	junctional	COSMIC cancer mutations	junctional	8	1	16828	49	FGFR3
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.306e-02	-3.77	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	actinic_keratosis	COSMIC cancer mutations	actinic_keratosis	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.309e-02	-3.77	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	5	16828	49	MAML2,TNIK,ERBB4,FGFR3,RYR3
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	CLU,SPARCL1,MACF1
2.329e-02	-3.76	actomyosin	cellular component	GO:0042641	92	2	19108	49	SORBS1,ABLIM1
2.331e-02	-3.76	amyloid-beta binding	molecular function	GO:0001540	89	2	18094	48	CST3,CLU
2.339e-02	-3.76	FNTA (farnesyltransferase, CAAX box, subunit alpha)	protein interactions	2339	92	2	19454	50	FGFR3,TNIK
2.339e-02	-3.76	SOX9 (SRY-box transcription factor 9)	protein interactions	6662	92	2	19454	50	NFIA,TRPS1
2.339e-02	-3.76	POTEI (POTE ankyrin domain family member I)	protein interactions	653269	92	2	19454	50	DTNA,FGFR3
2.352e-02	-3.75	organic anion transport	biological process	GO:0015711	398	4	18204	50	SLC1A3,SLC4A4,SFXN5,SLC1A2
2.353e-02	-3.75	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	43	ABLIM1
2.381e-02	-3.74	collagen-containing extracellular matrix	cellular component	GO:0062023	428	4	19108	49	PTPRZ1,CLU,GPC5,SPARCL1
2.384e-02	-3.74	DISC1 (DISC1 scaffold protein)	protein interactions	27185	427	4	19454	50	CLU,SPARCL1,MACF1,TNIK
2.387e-02	-3.74	Diseases of signal transduction	REACTOME pathways	R-HSA-5663202	369	4	10285	31	ERBB4,MAML2,FGFR3,MACF1
2.387e-02	-3.74	Downregulation of ERBB4 signaling	REACTOME pathways	R-HSA-1253288	8	1	10285	31	ERBB4
2.387e-02	-3.74	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	31	GPC5
2.387e-02	-3.74	MPDZ (multiple PDZ domain crumbs cell polarity complex component)	protein interactions	8777	93	2	19454	50	PARD3,FGFR3
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	ABLIM1,BMPR1B
2.387e-02	-3.74	ODR4 (odr-4 GPCR localization factor homolog)	protein interactions	54953	93	2	19454	50	LRIG1,GPM6A
2.388e-02	-3.73	hand	COSMIC cancer mutations	hand	566	5	16828	49	FGFR3,ERBB4,SLC4A4,PREX2,HIF3A
2.404e-02	-3.73	Prot_inh_cystat_CS	interpro domains	IPR018073	9	1	18521	50	CST3
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.408e-02	-3.73	ion binding	molecular function	GO:0043167	6007	23	18094	48	DTNA,SLC1A2,MACF1,PITPNC1,GLIS3,TRPS1,ATP1A2,FGFR3,RYR3,ERBB4,BMPR1B,SPARCL1,TNIK,SLC1A3,ABLIM1,RORA,PRKG1,PARD3,ACSS1,PTGDS,ZBTB20,ZNRF3,ATP13A4
2.433e-02	-3.72	Endochondral Ossification	WikiPathways	WP474	65	2	5310	20	SOX5,FGFR3
2.435e-02	-3.72	QSER1 (glutamine and serine rich 1)	protein interactions	79832	94	2	19454	50	SOX5,NFIA
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	TNIK,ABLIM1
2.435e-02	-3.72	FOXP4 (forkhead box P4)	protein interactions	116113	94	2	19454	50	NFIA,SOX5
2.435e-02	-3.72	TTR (transthyretin)	protein interactions	7276	94	2	19454	50	CLU,CTNND2
2.437e-02	-3.71	renal_cell_carcinoma	COSMIC cancer mutations	renal_cell_carcinoma	4535	20	16828	49	TRPS1,FBXL7,FGFR3,MACF1,PREX2,PRKG1,CTNND2,SOX5,ZNRF3,BMPR1B,ERBB4,PTPRZ1,HIF3A,TNIK,MSI2,RORA,LRIG1,PITPNC1,CLU,MAML2
2.437e-02	-3.71	kidney-carcinoma-renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma	4535	20	16828	49	FBXL7,TRPS1,CTNND2,SOX5,PREX2,PRKG1,FGFR3,MACF1,HIF3A,PTPRZ1,ZNRF3,BMPR1B,ERBB4,MAML2,PITPNC1,CLU,MSI2,RORA,LRIG1,TNIK
2.438e-02	-3.71	postsynapse	cellular component	GO:0098794	646	5	19108	49	ATP1A2,ERBB4,CTNND2,TNIK,GPM6A
2.445e-02	-3.71	GS	prosite domains	PS51256	7	1	12186	43	BMPR1B
2.446e-02	-3.71	microglial cell proliferation	biological process	GO:0061518	9	1	18204	50	CLU
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.446e-02	-3.71	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	50	ATP13A4
2.446e-02	-3.71	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	50	CTNNA2
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.446e-02	-3.71	macrophage proliferation	biological process	GO:0061517	9	1	18204	50	CLU
2.446e-02	-3.71	cyclooxygenase pathway	biological process	GO:0019371	9	1	18204	50	PTGDS
2.446e-02	-3.71	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	50	CTNNA2
2.459e-02	-3.71	human chr5p15.1	chromosome location	human chr5p15.1	13	1	26134	50	FBXL7
2.468e-02	-3.70	skeletal system morphogenesis	biological process	GO:0048705	228	3	18204	50	BMPR1B,SOX5,FGFR3
2.469e-02	-3.70	neck	COSMIC cancer mutations	neck	1231	8	16828	49	GPC5,PREX2,CTNND2,TRPM3,FGFR3,ATP13A4,ATP1A2,ERBB4
2.479e-02	-3.70	DDX31 (DEAD-box helicase 31)	protein interactions	64794	244	3	19454	50	PRKG1,CLU,CST3
2.487e-02	-3.69	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	2	18204	50	SORBS1,ZBTB20
2.495e-02	-3.69	axon	cellular component	GO:0030424	650	5	19108	49	GPM6A,SLC1A2,PARD3,CTNNA2,DTNA
2.501e-02	-3.69	Band_3_cyto	pfam domains	PF07565	9	1	17795	50	SLC4A4
2.501e-02	-3.69	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	50	RFX4
2.501e-02	-3.69	Activin_recp	pfam domains	PF01064	9	1	17795	50	BMPR1B
2.504e-02	-3.69	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	4	16828	49	FGFR3,TNIK,ERBB4,MAML2
2.504e-02	-3.69	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	FGFR3,ERBB4,TNIK,MAML2
2.504e-02	-3.69	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	ERBB4,TNIK,FGFR3,MAML2
2.504e-02	-3.69	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	MAML2,ERBB4,TNIK,FGFR3
2.504e-02	-3.69	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	4	16828	49	FGFR3,ERBB4,TNIK,MAML2
2.521e-02	-3.68	actin filament bundle	cellular component	GO:0032432	96	2	19108	49	ABLIM1,SORBS1
2.529e-02	-3.68	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	19	19454	50	SLC4A4,TNIK,PARD3,MACF1,CTNND2,CLU,CTNNA2,ACSS1,CST3,NTM,SLC1A3,LRIG1,LSAMP,MSI2,GPM6A,PTPRZ1,DTNA,ATP1A2,PITPNC1
2.536e-02	-3.67	perineuronal net	cellular component	GO:0072534	10	1	19108	49	PTPRZ1
2.539e-02	-3.67	regulation of purine nucleotide metabolic process	biological process	GO:1900542	90	2	18204	50	SLC4A4,ZBTB20
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	PTPRT (protein tyrosine phosphatase receptor type T)	protein interactions	11122	10	1	19454	50	ERBB4
2.541e-02	-3.67	EREG (epiregulin)	protein interactions	2069	10	1	19454	50	ERBB4
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.547e-02	-3.67	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	7	19454	50	SORBS1,MACF1,PARD3,PARD3B,NHSL1,ABLIM1,PITPNC1
2.551e-02	-3.67	lipid binding	molecular function	GO:0008289	861	6	18094	48	PARD3,PARD3B,ATP1A2,PITPNC1,RORA,PTGDS
2.566e-02	-3.66	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	12	16828	49	NHSL1,ATP1A2,SOX5,CTNND2,TRPM3,RFX4,ZBTB20,ZNRF3,PTPRZ1,SLC1A2,LRIG1,MAML2
2.581e-02	-3.66	PLCB3 (phospholipase C beta 3)	protein interactions	5331	97	2	19454	50	PRKG1,PARD3
2.581e-02	-3.66	SOCS3 (suppressor of cytokine signaling 3)	protein interactions	9021	97	2	19454	50	ERBB4,FGFR3
2.581e-02	-3.66	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	2	19454	50	SPARCL1,CLU
2.585e-02	-3.66	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	3	19454	50	TNIK,NFIA,SOX5
2.585e-02	-3.66	ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)	protein interactions	25	248	3	19454	50	ERBB4,CTNND2,SORBS1
2.586e-02	-3.66	parotid	COSMIC cancer mutations	parotid	578	5	16828	49	MAML2,FGFR3,ERBB4,TNIK,RYR3
2.589e-02	-3.65	shoulder	COSMIC cancer mutations	shoulder	387	4	16828	49	ERBB4,MACF1,FGFR3,PREX2
2.591e-02	-3.65	Bowen_disease	COSMIC cancer mutations	Bowen_disease	9	1	16828	49	FGFR3
2.591e-02	-3.65	compound	COSMIC cancer mutations	compound	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-other-seborrhoeic_keratosis	9	1	16828	49	FGFR3
2.591e-02	-3.65	in_situ_epithelial_neoplasm	COSMIC cancer mutations	in_situ_epithelial_neoplasm	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	skin-benign_melanocytic_nevus-congenital	COSMIC cancer mutations	skin-benign_melanocytic_nevus-congenital	9	1	16828	49	FGFR3
2.591e-02	-3.65	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	COSMIC cancer mutations	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	9	1	16828	49	FGFR3
2.591e-02	-3.65	epidermal_nevus	COSMIC cancer mutations	epidermal_nevus	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.592e-02	-3.65	cellular response to BMP stimulus	biological process	GO:0071773	91	2	18204	50	NFIA,BMPR1B
2.592e-02	-3.65	regulation of nucleotide metabolic process	biological process	GO:0006140	91	2	18204	50	ZBTB20,SLC4A4
2.592e-02	-3.65	response to BMP	biological process	GO:0071772	91	2	18204	50	NFIA,BMPR1B
2.609e-02	-3.65	PROTEIN_KINASE_DOM	prosite domains	PS50011	480	5	12186	43	TNIK,PRKG1,BMPR1B,ERBB4,FGFR3
2.610e-02	-3.65	cGMP signaling	KEGG pathways	hsa_M00694	9	1	7161	21	PRKG1
2.610e-02	-3.65	cGMP signaling	KEGG pathways	M00694	9	1	7161	21	PRKG1
2.621e-02	-3.64	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	44	16828	49	NHSL1,FBXL7,SLC1A3,SOX5,TRPM3,CTNND2,RFX4,PRKG1,SLC4A4,ATP13A4,NKAIN3,FGFR3,CST3,PTPRZ1,SORBS1,ERBB4,BMPR1B,ZNRF3,CLU,GPC5,RORA,SLC1A2,LRIG1,GLIS3,TNIK,GPM6A,ATP1A2,ACSS1,TRPS1,PARD3B,SPARCL1,PREX2,CDH20,MACF1,NTM,HIF3A,ZBTB20,PARD3,NPAS3,MAML2,SFXN5,PTGDS,RYR3,LSAMP
2.622e-02	-3.64	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	48	ATP13A4
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	GPM6A,LSAMP
2.636e-02	-3.64	PLEC	smart domains	SM00250	7	1	9717	37	MACF1
2.636e-02	-3.64	GS	smart domains	SM00467	7	1	9717	37	BMPR1B
2.637e-02	-3.64	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	50	TNIK,FGFR3,RYR3,PRKG1,PREX2,ATP1A2
2.645e-02	-3.63	protein tetramerization	biological process	GO:0051262	92	2	18204	50	TRPM3,RYR3
2.646e-02	-3.63	human chr2p13.2	chromosome location	human chr2p13.2	14	1	26134	50	SFXN5
2.654e-02	-3.63	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	49	PREX2,SLC4A4,FGFR3,PARD3B,ERBB4
2.666e-02	-3.62	TGFBR1 (transforming growth factor beta receptor 1)	protein interactions	7046	251	3	19454	50	CLU,BMPR1B,PREX2
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	SOX5,TRPS1
2.681e-02	-3.62	Terminal pathway of complement	REACTOME pathways	R-HSA-166665	9	1	10285	31	CLU
2.683e-02	-3.62	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	48	ATP13A4,ATP1A2
2.693e-02	-3.61	behavior	biological process	GO:0007610	619	5	18204	50	SLC1A3,PTPRZ1,PREX2,ATP1A2,SLC1A2
2.693e-02	-3.61	CRX (cone-rod homeobox)	protein interactions	1406	252	3	19454	50	NFIA,SOX5,TRPS1
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	neuronal action potential propagation	biological process	GO:0019227	10	1	18204	50	ATP1A2
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	otolith development	biological process	GO:0048840	10	1	18204	50	LRIG1
2.714e-02	-3.61	action potential propagation	biological process	GO:0098870	10	1	18204	50	ATP1A2
2.714e-02	-3.61	mitochondrial fragmentation involved in apoptotic process	biological process	GO:0043653	10	1	18204	50	ERBB4
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	ERBB4,FGFR3
2.719e-02	-3.60	response to organic cyclic compound	biological process	GO:0014070	843	6	18204	50	RYR3,PTGDS,SLC1A2,ATP1A2,SLC1A3,RORA
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	ATP1A2,GPM6A
2.741e-02	-3.60	uveal_tract	COSMIC cancer mutations	uveal_tract	587	5	16828	49	CTNND2,TRPM3,PREX2,FGFR3,MACF1
2.756e-02	-3.59	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	50	ERBB4,TNIK,MACF1
2.756e-02	-3.59	muscle contraction	biological process	GO:0006936	238	3	18204	50	DTNA,RYR3,ATP1A2
2.771e-02	-3.59	actin binding	molecular function	GO:0003779	434	4	18094	48	SORBS1,CTNNA2,MACF1,ABLIM1
2.775e-02	-3.58	HCO3_cotransp	pfam domains	PF00955	10	1	17795	50	SLC4A4
2.775e-02	-3.58	MIR	pfam domains	PF02815	10	1	17795	50	RYR3
2.775e-02	-3.58	PAS_3	pfam domains	PF08447	10	1	17795	50	NPAS3
2.776e-02	-3.58	DYNLL2 (dynein light chain LC8-type 2)	protein interactions	140735	255	3	19454	50	TRPS1,NHSL1,NFIA
2.781e-02	-3.58	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	50	FGFR3,CTNNA2
2.781e-02	-3.58	ILKAP (ILK associated serine/threonine phosphatase)	protein interactions	80895	101	2	19454	50	FGFR3,ERBB4
2.786e-02	-3.58	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	49	PTPRZ1
2.789e-02	-3.58	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	43	TRPS1
2.789e-02	-3.58	HP	prosite domains	PS51089	8	1	12186	43	ABLIM1
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.792e-02	-3.58	MSRB1 (methionine sulfoxide reductase B1)	protein interactions	51734	11	1	19454	50	CLU
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	PRKG1
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	CCDC17 (coiled-coil domain containing 17)	protein interactions	149483	11	1	19454	50	FGFR3
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	GAL3ST1 (galactose-3-O-sulfotransferase 1)	protein interactions	9514	11	1	19454	50	LRIG1
2.792e-02	-3.58	PTGDR (prostaglandin D2 receptor)	protein interactions	5729	11	1	19454	50	PTGDS
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.806e-02	-3.57	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME pathways	R-HSA-6811558	87	2	10285	31	ERBB4,FGFR3
2.809e-02	-3.57	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	50	ERBB4,FGFR3,BMPR1B,NFIA,SORBS1
2.831e-02	-3.56	ankle	COSMIC cancer mutations	ankle	398	4	16828	49	PREX2,PARD3,ERBB4,ATP13A4
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.849e-02	-3.56	transcription regulator activity	molecular function	GO:0140110	1937	10	18094	48	SOX5,NPAS3,GLIS3,ZBTB20,RFX4,HIF3A,MAML2,NFIA,TRPS1,RORA
2.862e-02	-3.55	pleura	COSMIC cancer mutations	pleura	4914	21	16828	49	NTM,HIF3A,PTPRZ1,ERBB4,BMPR1B,ZNRF3,MAML2,CLU,PITPNC1,RORA,LRIG1,MSI2,TNIK,FBXL7,TRPS1,SOX5,CTNND2,PREX2,PRKG1,ATP13A4,FGFR3
2.865e-02	-3.55	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	46	16828	49	CTNND2,SOX5,PRKG1,RFX4,ATP13A4,FGFR3,SLC1A3,GPC5,LRIG1,RORA,TNIK,GLIS3,PTPRZ1,ERBB4,PREX2,TRPS1,SFXN5,MAML2,PTGDS,PITPNC1,LSAMP,HIF3A,NTM,ABLIM1,DTNA,ZBTB20,PARD3,NPAS3,TRPM3,SLC4A4,FBXL7,CLU,SLC1A2,SORBS1,ZNRF3,BMPR1B,NFIA,CDH20,MACF1,ATP1A2,GPM6A,ACSS1,SPARCL1,PARD3B,RYR3,MSI2
2.873e-02	-3.55	LIPOCALIN	prints domains	PR00179	8	1	5227	19	PTGDS
2.873e-02	-3.55	GATAZNFINGER	prints domains	PR00619	8	1	5227	19	TRPS1
2.875e-02	-3.55	intradermal	COSMIC cancer mutations	intradermal	10	1	16828	49	FGFR3
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.875e-02	-3.55	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	kidney-carcinoma-renal_cell_carcinoma_unclassified	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	renal_cell_carcinoma_unclassified	COSMIC cancer mutations	renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	lung-carcinoma-pleomorphic_carcinoma	COSMIC cancer mutations	lung-carcinoma-pleomorphic_carcinoma	10	1	16828	49	FGFR3
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	BMPR1B,GPM6A
2.889e-02	-3.54	MARK2 (microtubule affinity regulating kinase 2)	protein interactions	2011	259	3	19454	50	PARD3,PARD3B,DTNA
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A2,SLC1A3
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	NTM,LSAMP,LRIG1,FGFR3
2.917e-02	-3.53	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	50	SLC1A2,SLC1A3
2.917e-02	-3.53	nerve development	biological process	GO:0021675	97	2	18204	50	LRIG1,SLC1A3
2.933e-02	-3.53	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	43	SLC4A4
2.946e-02	-3.52	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	3	19454	50	MACF1,PARD3,DTNA
2.972e-02	-3.52	kidney-carcinoma	COSMIC cancer mutations	kidney-carcinoma	3720	17	16828	49	MAML2,PITPNC1,LRIG1,RORA,MSI2,TNIK,HIF3A,PTPRZ1,ERBB4,BMPR1B,SOX5,CTNND2,PREX2,PRKG1,FGFR3,FBXL7,TRPS1
2.975e-02	-3.51	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	31	FGFR3
2.975e-02	-3.51	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	31	SLC4A4
2.975e-02	-3.51	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	31	ERBB4
2.981e-02	-3.51	polyamine transport	biological process	GO:0015846	11	1	18204	50	ATP13A4
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.981e-02	-3.51	negative regulation of platelet aggregation	biological process	GO:0090331	11	1	18204	50	PRKG1
2.981e-02	-3.51	physiological muscle hypertrophy	biological process	GO:0003298	11	1	18204	50	PRKG1
2.981e-02	-3.51	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	50	BMPR1B
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.981e-02	-3.51	physiological cardiac muscle hypertrophy	biological process	GO:0003301	11	1	18204	50	PRKG1
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	cell growth involved in cardiac muscle cell development	biological process	GO:0061049	11	1	18204	50	PRKG1
2.988e-02	-3.51	PI3K/AKT Signaling in Cancer	REACTOME pathways	R-HSA-2219528	90	2	10285	31	FGFR3,ERBB4
2.988e-02	-3.51	IRF2BP2 (interferon regulatory factor 2 binding protein 2)	protein interactions	359948	105	2	19454	50	ERBB4,NFIA
2.988e-02	-3.51	BEND3 (BEN domain containing 3)	protein interactions	57673	105	2	19454	50	TRPS1,TNIK
3.007e-02	-3.50	VHP	smart domains	SM00153	8	1	9717	37	ABLIM1
3.028e-02	-3.50	bone morphogenesis	biological process	GO:0060349	99	2	18204	50	BMPR1B,FGFR3
3.030e-02	-3.50	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	49	CTNND2,PREX2,LRIG1,ERBB4,FGFR3
3.034e-02	-3.50	response to wounding	biological process	GO:0009611	431	4	18204	50	MACF1,SLC1A3,NFIA,SLC1A2
3.035e-02	-3.49	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	49	PTPRZ1
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.039e-02	-3.49	skin-hand-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-hand-carcinoma-squamous_cell_carcinoma	407	4	16828	49	SLC4A4,FGFR3,ERBB4,HIF3A
3.042e-02	-3.49	OAS2 (2'-5'-oligoadenylate synthetase 2)	protein interactions	4939	12	1	19454	50	PRKG1
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	TREM2 (triggering receptor expressed on myeloid cells 2)	protein interactions	54209	12	1	19454	50	CLU
3.042e-02	-3.49	LGR5 (leucine rich repeat containing G protein-coupled receptor 5)	protein interactions	8549	12	1	19454	50	ZNRF3
3.042e-02	-3.49	IL15 (interleukin 15)	protein interactions	3600	12	1	19454	50	LRIG1
3.042e-02	-3.49	PTPN20 (protein tyrosine phosphatase non-receptor type 20)	protein interactions	26095	12	1	19454	50	ERBB4
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	MMP25 (matrix metallopeptidase 25)	protein interactions	64386	12	1	19454	50	CLU
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	Pard6b (par-6 family cell polarity regulator beta)	protein interactions	58220	12	1	19454	50	PARD3
3.042e-02	-3.49	SMIM20 (small integral membrane protein 20)	protein interactions	389203	12	1	19454	50	ERBB4
3.049e-02	-3.49	PAS_11	pfam domains	PF14598	11	1	17795	50	HIF3A
3.049e-02	-3.49	LRRCT	pfam domains	PF01463	11	1	17795	50	LRIG1
3.079e-02	-3.48	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	50	RYR3,ATP13A4,SLC1A3,ATP1A2
3.087e-02	-3.48	eye	COSMIC cancer mutations	eye	606	5	16828	49	PREX2,TRPM3,CTNND2,MACF1,FGFR3
3.105e-02	-3.47	Pancreatic secretion	KEGG pathways	hsa04972	95	2	7161	21	SLC4A4,ATP1A2
3.105e-02	-3.47	Pancreatic secretion	KEGG pathways	ko04972	95	2	7161	21	ATP1A2,SLC4A4
3.111e-02	-3.47	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	31	NTM,LSAMP
3.132e-02	-3.46	RFX_DBD	prosite domains	PS51526	9	1	12186	43	RFX4
3.132e-02	-3.46	CYSTATIN	prosite domains	PS00287	9	1	12186	43	CST3
3.142e-02	-3.46	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	50	SORBS1,RORA
3.142e-02	-3.46	regulation of carbohydrate biosynthetic process	biological process	GO:0043255	101	2	18204	50	PRKG1,SORBS1
3.147e-02	-3.46	PAX8 (paired box 8)	protein interactions	7849	108	2	19454	50	NFIA,TRPS1
3.147e-02	-3.46	EN1 (engrailed homeobox 1)	protein interactions	2019	108	2	19454	50	TRPS1,NFIA
3.147e-02	-3.46	BIN1 (bridging integrator 1)	protein interactions	274	108	2	19454	50	GPM6A,CLU
3.157e-02	-3.46	calcium ion transport	biological process	GO:0006816	251	3	18204	50	RYR3,GPM6A,TRPM3
3.158e-02	-3.46	skin-scalp-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-neck-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-neck-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.158e-02	-3.46	oncocytoma	COSMIC cancer mutations	oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	seborrhoeic_keratosis	COSMIC cancer mutations	seborrhoeic_keratosis	11	1	16828	49	FGFR3
3.158e-02	-3.46	prostate-hyperplasia	COSMIC cancer mutations	prostate-hyperplasia	11	1	16828	49	FGFR3
3.158e-02	-3.46	kidney-other-oncocytoma	COSMIC cancer mutations	kidney-other-oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	pleomorphic_carcinoma	COSMIC cancer mutations	pleomorphic_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	congenital	COSMIC cancer mutations	congenital	11	1	16828	49	FGFR3
3.166e-02	-3.45	Circadian entrainment	KEGG pathways	hsa04713	96	2	7161	21	PRKG1,RYR3
3.166e-02	-3.45	Circadian entrainment	KEGG pathways	ko04713	96	2	7161	21	RYR3,PRKG1
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.193e-02	-3.44	Lipocalin	interpro domains	IPR002345	12	1	18521	50	PTGDS
3.193e-02	-3.44	Lipocalin_CS	interpro domains	IPR022272	12	1	18521	50	PTGDS
3.193e-02	-3.44	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	37	16828	49	ERBB4,PTPRZ1,GLIS3,TNIK,SLC1A2,LRIG1,RORA,GPC5,SLC1A3,NHSL1,FBXL7,NKAIN3,SLC4A4,ATP13A4,RFX4,PRKG1,SOX5,TRPM3,CTNND2,NPAS3,PARD3,NTM,ABLIM1,HIF3A,MSI2,RYR3,LSAMP,MAML2,SFXN5,PARD3B,SPARCL1,ACSS1,ATP1A2,MACF1,CDH20,PREX2,NFIA
3.193e-02	-3.44	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	37	16828	49	NFIA,PREX2,CDH20,MACF1,ATP1A2,ACSS1,SPARCL1,PARD3B,MAML2,SFXN5,RYR3,LSAMP,MSI2,HIF3A,NTM,ABLIM1,PARD3,NPAS3,TRPM3,CTNND2,SOX5,PRKG1,RFX4,ATP13A4,SLC4A4,NKAIN3,FBXL7,NHSL1,SLC1A3,GPC5,RORA,LRIG1,SLC1A2,GLIS3,TNIK,PTPRZ1,ERBB4
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	SOX5,TRPM3
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	SLC1A3,NHSL1,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,ERBB4,PTPRZ1,CST3,GLIS3,TNIK,RORA,LRIG1,GPC5,TRPS1,PREX2,PARD3,NPAS3,ZBTB20,DTNA,NTM,ABLIM1,HIF3A,LSAMP,PITPNC1,PTGDS,MAML2,SFXN5,FBXL7,SLC4A4,TRPM3,BMPR1B,ZNRF3,SORBS1,SLC1A2,CLU,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,NFIA,MSI2,RYR3
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	RYR3,MSI2,ATP1A2,GPM6A,ACSS1,SPARCL1,PARD3B,NFIA,CDH20,MACF1,SORBS1,ZNRF3,BMPR1B,CLU,SLC1A2,FBXL7,TRPM3,SLC4A4,HIF3A,NTM,ABLIM1,DTNA,ZBTB20,NPAS3,PARD3,MAML2,SFXN5,PITPNC1,PTGDS,LSAMP,TRPS1,PREX2,CST3,PTPRZ1,ERBB4,GPC5,RORA,LRIG1,GLIS3,TNIK,NHSL1,SLC1A3,CTNND2,SOX5,PRKG1,RFX4,ATP13A4,FGFR3
3.237e-02	-3.43	Negative regulation of the PI3K/AKT network	REACTOME pathways	R-HSA-199418	94	2	10285	31	FGFR3,ERBB4
3.248e-02	-3.43	auditory behavior	biological process	GO:0031223	12	1	18204	50	SLC1A3
3.248e-02	-3.43	negative regulation of smooth muscle contraction	biological process	GO:0045986	12	1	18204	50	PRKG1
3.248e-02	-3.43	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	50	SLC1A2
3.248e-02	-3.43	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	50	BMPR1B
3.248e-02	-3.43	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	50	BMPR1B
3.248e-02	-3.43	regulation of blood vessel remodeling	biological process	GO:0060312	12	1	18204	50	CST3
3.248e-02	-3.43	negative regulation of collagen metabolic process	biological process	GO:0010713	12	1	18204	50	CST3
3.250e-02	-3.43	DNA-binding transcription repressor activity, RNA polymerase II-specific	molecular function	GO:0001227	263	3	18094	48	TRPS1,ZBTB20,GLIS3
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	BMPR1B,PARD3B
3.255e-02	-3.43	cellular component assembly	biological process	GO:0022607	2472	12	18204	50	CDH20,CLU,ERBB4,PARD3,TNIK,TRPM3,GPM6A,SLC1A2,SORBS1,ABLIM1,RFX4,RYR3
3.257e-02	-3.42	cerebellum development	biological process	GO:0021549	103	2	18204	50	PRKG1,RORA
3.271e-02	-3.42	RDX (radixin)	protein interactions	5962	272	3	19454	50	MACF1,ABLIM1,FGFR3
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	RORA,ATP1A2
3.291e-02	-3.41	JAM2 (junctional adhesion molecule 2)	protein interactions	58494	13	1	19454	50	PARD3
3.291e-02	-3.41	PLPPR4 (phospholipid phosphatase related 4)	protein interactions	9890	13	1	19454	50	ZNRF3
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.310e-02	-3.41	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	46	16828	49	SLC1A3,RFX4,PRKG1,SOX5,CTNND2,FGFR3,ATP13A4,PTPRZ1,ERBB4,GPC5,TNIK,GLIS3,RORA,LRIG1,TRPS1,PREX2,DTNA,ABLIM1,NTM,HIF3A,PARD3,NPAS3,ZBTB20,PITPNC1,PTGDS,MAML2,SFXN5,LSAMP,FBXL7,TRPM3,SLC4A4,SORBS1,BMPR1B,ZNRF3,CLU,SLC1A2,ACSS1,GPM6A,ATP1A2,PARD3B,SPARCL1,NFIA,MACF1,CDH20,RYR3,MSI2
3.310e-02	-3.41	bladder	COSMIC cancer mutations	bladder	14112	46	16828	49	BMPR1B,ZNRF3,SORBS1,SLC1A2,CLU,FBXL7,SLC4A4,TRPM3,MSI2,RYR3,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,NFIA,ERBB4,PTPRZ1,TNIK,GLIS3,RORA,LRIG1,GPC5,SLC1A3,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,PARD3,NPAS3,ZBTB20,DTNA,NTM,ABLIM1,HIF3A,LSAMP,PTGDS,PITPNC1,MAML2,SFXN5,TRPS1,PREX2
3.315e-02	-3.41	regulation of steroid metabolic process	biological process	GO:0019218	104	2	18204	50	PRKG1,RORA
3.318e-02	-3.41	protein complex oligomerization	biological process	GO:0051259	256	3	18204	50	TRPM3,RYR3,SLC1A2
3.321e-02	-3.40	MH1	pfam domains	PF03165	12	1	17795	50	NFIA
3.342e-02	-3.40	EV release from cardiac cells and their functional effects	WikiPathways	WP3297	9	1	5310	20	ERBB4
3.351e-02	-3.40	cell fate commitment	biological process	GO:0045165	257	3	18204	50	ERBB4,SOX5,NFIA
3.363e-02	-3.39	TSC22D4 (TSC22 domain family member 4)	protein interactions	81628	112	2	19454	50	ABLIM1,CLU
3.363e-02	-3.39	EDA (ectodysplasin A)	protein interactions	1896	112	2	19454	50	GPM6A,ERBB4
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	MACF1,TRPS1
3.377e-02	-3.39	FOLN	smart domains	SM00274	9	1	9717	37	SPARCL1
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.405e-02	-3.38	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	6	19454	50	ATP13A4,SLC1A3,NFIA,ZBTB20,CTNND2,TRPS1
3.418e-02	-3.38	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	7	19454	50	PARD3,MACF1,SORBS1,ABLIM1,PITPNC1,PARD3B,NHSL1
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	DTNA,ZNRF3
3.427e-02	-3.37	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	13	16828	49	NHSL1,ATP1A2,FGFR3,RFX4,SOX5,CTNND2,TRPM3,ZNRF3,ZBTB20,PTPRZ1,SLC1A2,LRIG1,MAML2
3.432e-02	-3.37	organ growth	biological process	GO:0035265	106	2	18204	50	PRKG1,FGFR3
3.439e-02	-3.37	ear	COSMIC cancer mutations	ear	624	5	16828	49	PRKG1,ZBTB20,SPARCL1,FGFR3,NPAS3
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.440e-02	-3.37	skin-benign_melanocytic_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus	12	1	16828	49	FGFR3
3.440e-02	-3.37	cervix-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	cervix-carcinoma-mixed_adenosquamous_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-face-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-basal_cell_carcinoma	12	1	16828	49	FGFR3
3.455e-02	-3.37	phosphotransferase activity, alcohol group as acceptor	molecular function	GO:0016773	686	5	18094	48	ERBB4,BMPR1B,PRKG1,TNIK,FGFR3
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	ATP1A2,SORBS1
3.459e-02	-3.36	small molecule binding	molecular function	GO:0036094	6197	23	18094	48	ATP1A2,FGFR3,TRPS1,GLIS3,PITPNC1,MACF1,DTNA,SLC1A2,PTGDS,ATP13A4,ZNRF3,ZBTB20,PARD3,ACSS1,RORA,PRKG1,SLC1A3,ABLIM1,SPARCL1,TNIK,BMPR1B,ERBB4,RYR3
3.474e-02	-3.36	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	50	ZBTB20,MACF1
3.474e-02	-3.36	MIR	prosite domains	PS50919	10	1	12186	43	RYR3
3.487e-02	-3.36	RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	GO:0000978	1180	7	18094	48	HIF3A,RFX4,ZBTB20,GLIS3,SOX5,RORA,NFIA
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	TRPM3,RYR3
3.510e-02	-3.35	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	43	CTNNA2
3.514e-02	-3.35	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	50	RORA
3.514e-02	-3.35	negative regulation of homotypic cell-cell adhesion	biological process	GO:0034111	13	1	18204	50	PRKG1
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	prepulse inhibition	biological process	GO:0060134	13	1	18204	50	CTNNA2
3.514e-02	-3.35	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	50	RORA
3.514e-02	-3.35	olfactory bulb interneuron differentiation	biological process	GO:0021889	13	1	18204	50	ERBB4
3.514e-02	-3.35	negative regulation of amyloid fibril formation	biological process	GO:1905907	13	1	18204	50	CLU
3.514e-02	-3.35	glial cell fate commitment	biological process	GO:0021781	13	1	18204	50	NFIA
3.527e-02	-3.34	ACTB (actin beta)	protein interactions	60	958	6	19454	50	SORBS1,SFXN5,MACF1,DTNA,NHSL1,ABLIM1
3.530e-02	-3.34	TBXT (T-box transcription factor T)	protein interactions	6862	115	2	19454	50	TRPS1,NFIA
3.530e-02	-3.34	CDH2 (cadherin 2)	protein interactions	1000	115	2	19454	50	CTNND2,PARD3
3.532e-02	-3.34	chromaffin granule	cellular component	GO:0042583	14	1	19108	49	CLU
3.532e-02	-3.34	Ethanol Degradation	SMPDB pathways	SMP0000449	7	1	1369	7	ACSS1
3.532e-02	-3.34	g-Secretase Mediated ErbB4 Signalling Pathway	SMPDB pathways	SMP0089975	7	1	1369	7	ERBB4
3.538e-02	-3.34	DNA-binding transcription repressor activity	molecular function	GO:0001217	272	3	18094	48	TRPS1,ZBTB20,GLIS3
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	MB (myoglobin)	protein interactions	4151	14	1	19454	50	MAML2
3.540e-02	-3.34	FGF7 (fibroblast growth factor 7)	protein interactions	2252	14	1	19454	50	FGFR3
3.540e-02	-3.34	GAGE1 (G antigen 1)	protein interactions	2543	14	1	19454	50	PRKG1
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	ZBTB20
3.540e-02	-3.34	CTSO (cathepsin O)	protein interactions	1519	14	1	19454	50	CST3
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	Stag2 (STAG2 cohesin complex component)	protein interactions	20843	14	1	19454	50	CLU
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	ZNRF3
3.540e-02	-3.34	Aifm1 (apoptosis-inducing factor, mitochondrion-associated 1)	protein interactions	26926	14	1	19454	50	CLU
3.540e-02	-3.34	C9 (complement C9)	protein interactions	735	14	1	19454	50	CLU
3.553e-02	-3.34	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	48	16828	49	ERBB4,PTPRZ1,TNIK,GLIS3,RORA,LRIG1,GPC5,SLC1A3,NHSL1,NKAIN3,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,NPAS3,PARD3,ZBTB20,DTNA,ABLIM1,NTM,HIF3A,LSAMP,PITPNC1,PTGDS,MAML2,SFXN5,TRPS1,PREX2,BMPR1B,ZNRF3,SORBS1,SLC1A2,CLU,FBXL7,SLC4A4,TRPM3,RYR3,MSI2,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,MACF1,CDH20,NFIA
3.559e-02	-3.34	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	31	GPC5
3.559e-02	-3.34	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	31	GPC5
3.559e-02	-3.34	Signaling by activated point mutants of FGFR3	REACTOME pathways	R-HSA-1839130	12	1	10285	31	FGFR3
3.559e-02	-3.34	FGFR3 mutant receptor activation	REACTOME pathways	R-HSA-2033514	12	1	10285	31	FGFR3
3.559e-02	-3.34	Ethanol oxidation	REACTOME pathways	R-HSA-71384	12	1	10285	31	ACSS1
3.559e-02	-3.34	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	31	HIF3A
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.579e-02	-3.33	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	19	SLC4A4
3.586e-02	-3.33	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	2	19454	50	SPARCL1,MACF1
3.586e-02	-3.33	RBBP8 (RB binding protein 8, endonuclease)	protein interactions	5932	116	2	19454	50	CTNNA2,CLU
3.610e-02	-3.32	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	16	16828	49	ATP1A2,PARD3B,PRKG1,PREX2,CTNND2,TRPM3,MACF1,SLC4A4,PTPRZ1,PARD3,NPAS3,ERBB4,ZBTB20,GPC5,RYR3,LRIG1
3.612e-02	-3.32	positive regulation of tumor necrosis factor production	biological process	GO:0032760	109	2	18204	50	CLU,ZBTB20
3.620e-02	-3.32	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	50	ZNRF3,CTNND2,GPC5
3.642e-02	-3.31	ELK3 (ETS transcription factor ELK3)	protein interactions	2004	117	2	19454	50	NFIA,TRPS1
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.668e-02	-3.31	CAV1 (caveolin 1)	protein interactions	857	719	5	19454	50	DTNA,TNIK,SLC1A3,PARD3,MACF1
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	PARD3,PARD3B,PITPNC1
3.678e-02	-3.30	bHLH_dom	interpro domains	IPR011598	112	2	18521	50	HIF3A,NPAS3
3.678e-02	-3.30	HLH_DNA-bd_sf	interpro domains	IPR036638	112	2	18521	50	HIF3A,NPAS3
3.702e-02	-3.30	TyrKc	smart domains	SM00219	80	2	9717	37	ERBB4,FGFR3
3.717e-02	-3.29	regulation of phosphate metabolic process	biological process	GO:0019220	1154	7	18204	50	TNIK,SLC4A4,PARD3,FGFR3,ERBB4,PRKG1,ZBTB20
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	endometrium-ovary-endometriosis	COSMIC cancer mutations	endometrium-ovary-endometriosis	13	1	16828	49	FGFR3
3.721e-02	-3.29	cervix-carcinoma-adenocarcinoma	COSMIC cancer mutations	cervix-carcinoma-adenocarcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	Brenner_tumour	COSMIC cancer mutations	Brenner_tumour	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	skin-back-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-back-carcinoma-basal_cell_carcinoma	13	1	16828	49	FGFR3
3.732e-02	-3.29	regulation of phosphorus metabolic process	biological process	GO:0051174	1155	7	18204	50	ZBTB20,PRKG1,TNIK,SLC4A4,ERBB4,PARD3,FGFR3
3.745e-02	-3.28	MIR	smart domains	SM00472	10	1	9717	37	RYR3
3.754e-02	-3.28	basal plasma membrane	cellular component	GO:0009925	288	3	19108	49	SLC1A3,ERBB4,SLC4A4
3.759e-02	-3.28	human chr8p21.1	chromosome location	human chr8p21.1	20	1	26134	50	CLU
3.762e-02	-3.28	phosphate-containing compound metabolic process	biological process	GO:0006796	1681	9	18204	50	ACSS1,ERBB4,BMPR1B,FGFR3,TNIK,PRKG1,RORA,ATP1A2,PTPRZ1
3.764e-02	-3.28	Ion_trans	pfam domains	PF00520	109	2	17795	50	TRPM3,RYR3
3.768e-02	-3.28	ATP binding	molecular function	GO:0005524	1467	8	18094	48	FGFR3,ATP13A4,ATP1A2,ACSS1,TNIK,PRKG1,ERBB4,BMPR1B
3.771e-02	-3.28	protein localization to membrane	biological process	GO:0072657	462	4	18204	50	TNIK,MACF1,ERBB4,PARD3
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	neurotransmitter receptor localization to postsynaptic specialization membrane	biological process	GO:0099645	14	1	18204	50	ERBB4
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	protein localization to postsynaptic specialization membrane	biological process	GO:0099633	14	1	18204	50	ERBB4
3.779e-02	-3.28	acetyl-CoA biosynthetic process	biological process	GO:0006085	14	1	18204	50	ACSS1
3.779e-02	-3.28	mechanosensory behavior	biological process	GO:0007638	14	1	18204	50	SLC1A3
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	FGF9 (fibroblast growth factor 9)	protein interactions	2254	15	1	19454	50	FGFR3
3.788e-02	-3.27	NPR1 (natriuretic peptide receptor 1)	protein interactions	4881	15	1	19454	50	PRKG1
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CLU
3.814e-02	-3.27	cis-regulatory region sequence-specific DNA binding	molecular function	GO:0000987	1203	7	18094	48	SOX5,GLIS3,RFX4,HIF3A,ZBTB20,NFIA,RORA
3.815e-02	-3.27	LIPOCALIN	prosite domains	PS00213	11	1	12186	43	PTGDS
3.815e-02	-3.27	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	43	TRPS1
3.819e-02	-3.27	membrane raft	cellular component	GO:0045121	290	3	19108	49	SLC1A2,SORBS1,ATP1A2
3.829e-02	-3.26	carboxylic acid biosynthetic process	biological process	GO:0046394	271	3	18204	50	PTGDS,SLC1A3,ACSS1
3.850e-02	-3.26	FGFR3c ligand binding and activation	REACTOME pathways	R-HSA-190372	13	1	10285	31	FGFR3
3.850e-02	-3.26	Phospholipase C-mediated cascade; FGFR3	REACTOME pathways	R-HSA-5654227	13	1	10285	31	FGFR3
3.850e-02	-3.26	FGFR3 ligand binding and activation	REACTOME pathways	R-HSA-190239	13	1	10285	31	FGFR3
3.850e-02	-3.26	Notch-HLH transcription pathway	REACTOME pathways	R-HSA-350054	13	1	10285	31	MAML2
3.850e-02	-3.26	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	31	ERBB4
3.850e-02	-3.26	NOTCH2 intracellular domain regulates transcription	REACTOME pathways	R-HSA-2197563	13	1	10285	31	MAML2
3.856e-02	-3.26	metencephalon development	biological process	GO:0022037	113	2	18204	50	RORA,PRKG1
3.856e-02	-3.26	positive regulation of tumor necrosis factor superfamily cytokine production	biological process	GO:1903557	113	2	18204	50	ZBTB20,CLU
3.864e-02	-3.25	GATA	pfam domains	PF00320	14	1	17795	50	TRPS1
3.881e-02	-3.25	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	2	16828	49	PARD3B,HIF3A
3.881e-02	-3.25	Endocytosis	KEGG pathways	ko04144	260	3	7161	21	ERBB4,FGFR3,PARD3
3.881e-02	-3.25	Endocytosis	KEGG pathways	hsa04144	260	3	7161	21	ERBB4,FGFR3,PARD3
3.885e-02	-3.25	membrane microdomain	cellular component	GO:0098857	292	3	19108	49	SLC1A2,SORBS1,ATP1A2
3.893e-02	-3.25	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	31	TRPM3,RYR3
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.908e-02	-3.24	AMP binding	molecular function	GO:0016208	15	1	18094	48	ACSS1
3.914e-02	-3.24	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	49	PTPRZ1,SLC4A4,ATP13A4
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	DTNA,NHSL1
3.936e-02	-3.24	organic acid biosynthetic process	biological process	GO:0016053	274	3	18204	50	ACSS1,SLC1A3,PTGDS
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.943e-02	-3.23	cell migration	biological process	GO:0016477	921	6	18204	50	PRKG1,ERBB4,CTNNA2,CDH20,GPC5,GPM6A
3.967e-02	-3.23	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	46	16828	49	NKAIN3,FGFR3,ATP13A4,RFX4,PRKG1,SOX5,CTNND2,SLC1A3,NHSL1,TNIK,GLIS3,LRIG1,RORA,GPC5,ERBB4,PTPRZ1,PREX2,TRPS1,LSAMP,PITPNC1,MAML2,SFXN5,NPAS3,PARD3,ZBTB20,DTNA,ABLIM1,NTM,HIF3A,SLC4A4,TRPM3,FBXL7,SLC1A2,CLU,BMPR1B,ZNRF3,SORBS1,MACF1,CDH20,NFIA,PARD3B,SPARCL1,ACSS1,GPM6A,ATP1A2,RYR3
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.981e-02	-3.22	fatty acid biosynthetic process	biological process	GO:0006633	115	2	18204	50	PTGDS,ACSS1
3.988e-02	-3.22	EF_HAND_2	prosite domains	PS50222	215	3	12186	43	SPARCL1,RYR3,MACF1
3.988e-02	-3.22	PAX7 (paired box 7)	protein interactions	5081	123	2	19454	50	TRPS1,NFIA
4.002e-02	-3.22	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	14	1	16828	49	FGFR3
4.002e-02	-3.22	small_round_cell_tumour	COSMIC cancer mutations	small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	endometriosis	COSMIC cancer mutations	endometriosis	14	1	16828	49	FGFR3
4.002e-02	-3.22	in_situ_neoplasm	COSMIC cancer mutations	in_situ_neoplasm	14	1	16828	49	FGFR3
4.002e-02	-3.22	soft_tissue-small_round_cell_tumour	COSMIC cancer mutations	soft_tissue-small_round_cell_tumour	14	1	16828	49	FGFR3
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.028e-02	-3.21	Bile Acid Indirect Signalling Pathway	SMPDB pathways	SMP0086851	8	1	1369	7	FGFR3
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKG1
4.035e-02	-3.21	CTSK (cathepsin K)	protein interactions	1513	16	1	19454	50	FGFR3
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	ZNRF3
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	HLA-H (major histocompatibility complex, class I, H (pseudogene))	protein interactions	3136	16	1	19454	50	FGFR3
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	MACF1
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	TMEM134 (transmembrane protein 134)	protein interactions	80194	16	1	19454	50	ERBB4
4.035e-02	-3.21	NBL1 (NBL1, DAN family BMP antagonist)	protein interactions	4681	16	1	19454	50	LRIG1
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	collateral sprouting	biological process	GO:0048668	15	1	18204	50	PRKG1
4.043e-02	-3.21	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	50	SORBS1
4.043e-02	-3.21	synapse maturation	biological process	GO:0060074	15	1	18204	50	NFIA
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.043e-02	-3.21	chondrocyte proliferation	biological process	GO:0035988	15	1	18204	50	FGFR3
4.043e-02	-3.21	regulation of circadian sleep/wake cycle, sleep	biological process	GO:0045187	15	1	18204	50	PTGDS
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	regulation of inositol phosphate biosynthetic process	biological process	GO:0010919	15	1	18204	50	PRKG1
4.043e-02	-3.21	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	50	RORA
4.043e-02	-3.21	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	50	MACF1
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	negative regulation of amino acid transport	biological process	GO:0051956	15	1	18204	50	PRKG1
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.043e-02	-3.21	exit from mitosis	biological process	GO:0010458	15	1	18204	50	NFIA
4.079e-02	-3.20	SP7 (Sp7 transcription factor)	protein interactions	121340	297	3	19454	50	NFIA,TRPS1,SOX5
4.081e-02	-3.20	Circadian rythm related genes	WikiPathways	WP3594	207	3	5310	20	PTGDS,RORA,CST3
4.092e-02	-3.20	phosphorus metabolic process	biological process	GO:0006793	1707	9	18204	50	PRKG1,TNIK,ACSS1,BMPR1B,FGFR3,ERBB4,ATP1A2,PTPRZ1,RORA
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	LRIG1,LSAMP,FGFR3,NTM
4.106e-02	-3.19	SOCS6 (suppressor of cytokine signaling 6)	protein interactions	9306	125	2	19454	50	BMPR1B,ERBB4
4.117e-02	-3.19	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	48	SLC1A2,SLC1A3,SLC4A4
4.118e-02	-3.19	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	10	16828	49	PARD3,ERBB4,FBXL7,ACSS1,PTPRZ1,ATP13A4,CDH20,RYR3,PREX2,PITPNC1
4.128e-02	-3.19	positive regulation of cellular process	biological process	GO:0048522	5719	22	18204	50	RORA,GPC5,GPM6A,GLIS3,SORBS1,ZBTB20,SLC1A2,RFX4,FGFR3,MACF1,NFIA,PTPRZ1,SLC1A3,CLU,MAML2,BMPR1B,ERBB4,SOX5,PARD3,SLC4A4,TNIK,NPAS3
4.134e-02	-3.19	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	50	ATP1A2
4.134e-02	-3.19	CNH	pfam domains	PF00780	15	1	17795	50	TNIK
4.141e-02	-3.18	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	31	ERBB4
4.141e-02	-3.18	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	31	ABLIM1
4.148e-02	-3.18	bicellular tight junction	cellular component	GO:0005923	126	2	19108	49	PARD3,PARD3B
4.155e-02	-3.18	CNMP_BINDING_2	prosite domains	PS00889	12	1	12186	43	PRKG1
4.163e-02	-3.18	cGMP binding	molecular function	GO:0030553	16	1	18094	48	PRKG1
4.163e-02	-3.18	misfolded protein binding	molecular function	GO:0051787	16	1	18094	48	CLU
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.168e-02	-3.18	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	5	18204	50	ZBTB20,TNIK,SLC4A4,FGFR3,ERBB4
4.168e-02	-3.18	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	5	18204	50	ZBTB20,ERBB4,FGFR3,SLC4A4,TNIK
4.170e-02	-3.18	synapse assembly	biological process	GO:0007416	118	2	18204	50	GPM6A,ERBB4
4.193e-02	-3.17	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	50	SORBS1,ZNRF3,CTNND2,MAML2,NFIA,BMPR1B,FGFR3,ERBB4,MACF1,TNIK
4.193e-02	-3.17	response to stimulus	biological process	GO:0050896	7803	28	18204	50	DTNA,SLC1A2,SORBS1,ZBTB20,PITPNC1,GPM6A,RYR3,CTNNA2,MACF1,MAML2,CLU,TNIK,BMPR1B,CTNND2,ZNRF3,ATP1A2,RORA,PTGDS,NFIA,SPARCL1,FGFR3,PREX2,SLC1A3,PRKG1,CST3,PARD3,ERBB4,SOX5
4.195e-02	-3.17	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	14	18204	50	CLU,SORBS1,ZBTB20,RFX4,MAML2,RORA,GLIS3,NFIA,NPAS3,SLC4A4,BMPR1B,FGFR3,ERBB4,TNIK
4.223e-02	-3.16	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	3	16828	49	RYR3,CDH20,SOX5
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	NFIA,TRPS1
4.235e-02	-3.16	cNMP-bd_CS	interpro domains	IPR018488	16	1	18521	50	PRKG1
4.250e-02	-3.16	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	8	16828	49	CTNND2,TRPM3,RYR3,ATP13A4,MACF1,ATP1A2,ERBB4,PARD3B
4.273e-02	-3.15	apical dendrite	cellular component	GO:0097440	17	1	19108	49	CLU
4.282e-02	-3.15	ureter	COSMIC cancer mutations	ureter	15	1	16828	49	FGFR3
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	NOTCH4 (notch receptor 4)	protein interactions	4855	17	1	19454	50	MAML2
4.282e-02	-3.15	SHD (Src homology 2 domain containing transforming protein D)	protein interactions	56961	17	1	19454	50	ERBB4
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.286e-02	-3.15	TEAD2 (TEA domain transcription factor 2)	protein interactions	8463	128	2	19454	50	TRPS1,ZBTB20
4.286e-02	-3.15	MYB (MYB proto-oncogene, transcription factor)	protein interactions	4602	128	2	19454	50	TRPS1,NFIA
4.294e-02	-3.15	Helix-loop-helix DNA-binding domain	gene3d domains	4.10.280.10	111	2	14470	43	NPAS3,HIF3A
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	short-chain fatty acid metabolic process	biological process	GO:0046459	16	1	18204	50	ACSS1
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.307e-02	-3.14	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	50	SLC1A3
4.307e-02	-3.14	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	50	ZNRF3
4.311e-02	-3.14	human chr2q34	chromosome location	human chr2q34	23	1	26134	50	ERBB4
4.333e-02	-3.14	Glutamatergic synapse	KEGG pathways	hsa04724	114	2	7161	21	SLC1A3,SLC1A2
4.333e-02	-3.14	Glutamatergic synapse	KEGG pathways	ko04724	114	2	7161	21	SLC1A2,SLC1A3
4.333e-02	-3.14	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	43	FGFR3,ERBB4
4.346e-02	-3.14	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	2	19454	50	ZBTB20,ABLIM1
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	SOX5,ZBTB20
4.352e-02	-3.13	skin-chest-malignant_melanoma	COSMIC cancer mutations	skin-chest-malignant_melanoma	114	2	16828	49	ERBB4,PREX2
4.368e-02	-3.13	pleura-mesothelioma	COSMIC cancer mutations	pleura-mesothelioma	4189	18	16828	49	PTPRZ1,HIF3A,BMPR1B,ERBB4,CLU,PITPNC1,MAML2,TNIK,MSI2,LRIG1,RORA,FBXL7,TRPS1,PRKG1,PREX2,CTNND2,SOX5,FGFR3
4.389e-02	-3.13	actin cytoskeleton	cellular component	GO:0015629	520	4	19108	49	MACF1,ABLIM1,SORBS1,CTNNA2
4.400e-02	-3.12	basal part of cell	cellular component	GO:0045178	307	3	19108	49	SLC4A4,ERBB4,SLC1A3
4.407e-02	-3.12	DVL1 (dishevelled segment polarity protein 1)	protein interactions	1855	130	2	19454	50	PARD3,ZNRF3
4.417e-02	-3.12	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	48	PTPRZ1
4.417e-02	-3.12	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	48	PTPRZ1
4.424e-02	-3.12	Ig-like_fold	interpro domains	IPR013783	721	5	18521	50	NTM,FGFR3,LRIG1,PTPRZ1,LSAMP
4.430e-02	-3.12	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	REACTOME pathways	R-HSA-2162123	15	1	10285	31	PTGDS
4.430e-02	-3.12	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	31	ERBB4
4.432e-02	-3.12	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	20	RYR3
4.432e-02	-3.12	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	20	BMPR1B
4.449e-02	-3.11	tight junction	cellular component	GO:0070160	131	2	19108	49	PARD3B,PARD3
4.468e-02	-3.11	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	50	RORA,NFIA
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	NFIA,SOX5
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	SOX5,NFIA
4.477e-02	-3.11	ZnF_GATA	smart domains	SM00401	12	1	9717	37	TRPS1
4.477e-02	-3.11	DWA	smart domains	SM00523	12	1	9717	37	NFIA
4.493e-02	-3.10	AMP-bd_C	interpro domains	IPR025110	17	1	18521	50	ACSS1
4.493e-02	-3.10	Cystatin_dom	interpro domains	IPR000010	17	1	18521	50	CST3
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	PAC	interpro domains	IPR001610	17	1	18521	50	HIF3A
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.499e-02	-3.10	ITCH (itchy E3 ubiquitin protein ligase)	protein interactions	83737	309	3	19454	50	ERBB4,RORA,GLIS3
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	ACSS1,ATP1A2,GPM6A,SPARCL1,PARD3B,NFIA,MACF1,CDH20,RYR3,MSI2,FBXL7,TRPM3,SLC4A4,SORBS1,ZNRF3,BMPR1B,CLU,SLC1A2,TRPS1,PREX2,DTNA,HIF3A,NTM,ABLIM1,NPAS3,PARD3,ZBTB20,PTGDS,PITPNC1,SFXN5,MAML2,LSAMP,NHSL1,SLC1A3,PRKG1,RFX4,CTNND2,SOX5,FGFR3,NKAIN3,ATP13A4,PTPRZ1,CST3,ERBB4,GPC5,GLIS3,TNIK,RORA,LRIG1
4.525e-02	-3.10	kinase activity	molecular function	GO:0016301	739	5	18094	48	ERBB4,BMPR1B,FGFR3,TNIK,PRKG1
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	PTGFR (prostaglandin F receptor)	protein interactions	5737	18	1	19454	50	PTGDS
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	CYP2E1 (cytochrome P450 family 2 subfamily E member 1)	protein interactions	1571	18	1	19454	50	CLU
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKG1
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.558e-02	-3.09	cellular process	biological process	GO:0009987	14996	46	18204	50	CTNND2,ABLIM1,ZNRF3,GLIS3,LSAMP,RORA,GPC5,ATP13A4,PTGDS,MSI2,SLC1A3,PREX2,NTM,PARD3,SLC4A4,NHSL1,DTNA,PITPNC1,GPM6A,RYR3,FBXL7,CTNNA2,SFXN5,MAML2,PTPRZ1,TRPM3,BMPR1B,RFX4,ATP1A2,NFIA,SPARCL1,FGFR3,PARD3B,CDH20,CST3,PRKG1,SOX5,ERBB4,ACSS1,ZBTB20,SORBS1,SLC1A2,MACF1,CLU,HIF3A,TNIK
4.560e-02	-3.09	positive regulation of lipid metabolic process	biological process	GO:0045834	124	2	18204	50	SORBS1,ZBTB20
4.561e-02	-3.09	urinary_tract-carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma	16	1	16828	49	FGFR3
4.561e-02	-3.09	normal	COSMIC cancer mutations	normal	16	1	16828	49	FGFR3
4.561e-02	-3.09	renal_pelvis	COSMIC cancer mutations	renal_pelvis	16	1	16828	49	FGFR3
4.561e-02	-3.09	flank	COSMIC cancer mutations	flank	16	1	16828	49	FGFR3
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	ureter development	biological process	GO:0072189	17	1	18204	50	NFIA
4.570e-02	-3.09	reverse cholesterol transport	biological process	GO:0043691	17	1	18204	50	CLU
4.570e-02	-3.09	mammary gland epithelial cell differentiation	biological process	GO:0060644	17	1	18204	50	ERBB4
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	50	CTNNA2
4.570e-02	-3.09	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	50	SORBS1
4.570e-02	-3.09	viral genome replication	biological process	GO:0019079	17	1	18204	50	NFIA
4.570e-02	-3.09	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	50	RORA
4.570e-02	-3.09	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	50	ATP1A2
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	TNIK
4.570e-02	-3.09	regulation of inclusion body assembly	biological process	GO:0090083	17	1	18204	50	CLU
4.570e-02	-3.09	cGMP metabolic process	biological process	GO:0046068	17	1	18204	50	RORA
4.570e-02	-3.09	regulation of amyloid fibril formation	biological process	GO:1905906	17	1	18204	50	CLU
4.579e-02	-3.08	endoplasmic reticulum lumen	cellular component	GO:0005788	312	3	19108	49	CST3,SPARCL1,CLU
4.621e-02	-3.07	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	8	18094	48	ERBB4,BMPR1B,TNIK,PRKG1,ACSS1,FGFR3,ATP13A4,ATP1A2
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	GPM6A,NTM
4.671e-02	-3.06	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	48	RYR3
4.671e-02	-3.06	GABA receptor binding	molecular function	GO:0050811	18	1	18094	48	ERBB4
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.673e-02	-3.06	Carb_anhydrase	pfam domains	PF00194	17	1	17795	50	PTPRZ1
4.673e-02	-3.06	ZZ	pfam domains	PF00569	17	1	17795	50	DTNA
4.673e-02	-3.06	Cystatin	pfam domains	PF00031	17	1	17795	50	CST3
4.673e-02	-3.06	AMP-binding_C	pfam domains	PF13193	17	1	17795	50	ACSS1
4.674e-02	-3.06	GRB2 (growth factor receptor bound protein 2)	protein interactions	2885	769	5	19454	50	ERBB4,FGFR3,MSI2,SLC1A2,CLU
4.716e-02	-3.05	FOXP1 (forkhead box P1)	protein interactions	27086	135	2	19454	50	NFIA,SOX5
4.716e-02	-3.05	BMP4 (bone morphogenetic protein 4)	protein interactions	652	135	2	19454	50	BMPR1B,CLU
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	TRPS1,ABLIM1
4.716e-02	-3.05	SOX15 (SRY-box transcription factor 15)	protein interactions	6665	135	2	19454	50	NFIA,TRPS1
4.718e-02	-3.05	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	1	10285	31	ERBB4
4.718e-02	-3.05	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	31	ERBB4
4.718e-02	-3.05	Rap1 signalling	REACTOME pathways	R-HSA-392517	16	1	10285	31	PRKG1
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	SORBS1,BMPR1B,ZNRF3,CLU,SLC1A2,FBXL7,TRPM3,SLC4A4,MSI2,RYR3,GPM6A,ATP1A2,ACSS1,PARD3B,SPARCL1,NFIA,CDH20,MACF1,CST3,PTPRZ1,ERBB4,GPC5,RORA,LRIG1,TNIK,GLIS3,NHSL1,SLC1A3,SOX5,CTNND2,RFX4,PRKG1,ATP13A4,NKAIN3,FGFR3,NTM,ABLIM1,HIF3A,DTNA,ZBTB20,PARD3,NPAS3,SFXN5,MAML2,PTGDS,PITPNC1,LSAMP,TRPS1,PREX2
4.752e-02	-3.05	Leu-rich_rpt_4	interpro domains	IPR025875	18	1	18521	50	LRIG1
4.752e-02	-3.05	Leu-rich_rpt_Cys-con_subtyp	interpro domains	IPR006553	18	1	18521	50	FBXL7
4.752e-02	-3.05	Furin_repeat	interpro domains	IPR006212	18	1	18521	50	ERBB4
4.754e-02	-3.05	ZYX (zyxin)	protein interactions	7791	316	3	19454	50	MACF1,ABLIM1,SORBS1
4.760e-02	-3.05	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	50	PARD3,CDH20
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	ERBB4,CTNND2,TNIK
4.764e-02	-3.04	astrocyte projection	cellular component	GO:0097449	19	1	19108	49	SLC1A2
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	FBXO27 (F-box protein 27)	protein interactions	126433	19	1	19454	50	CLU
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	ZNF532 (zinc finger protein 532)	protein interactions	55205	19	1	19454	50	ERBB4
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	HBEGF (heparin binding EGF like growth factor)	protein interactions	1839	19	1	19454	50	ERBB4
4.793e-02	-3.04	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	1	5310	20	RYR3
4.804e-02	-3.04	carboxylic acid transport	biological process	GO:0046942	297	3	18204	50	SLC1A3,SFXN5,SLC1A2
4.827e-02	-3.03	myelination	biological process	GO:0042552	128	2	18204	50	CLU,PARD3
4.827e-02	-3.03	glial cell development	biological process	GO:0021782	128	2	18204	50	PARD3,CLU
4.832e-02	-3.03	response to misfolded protein	biological process	GO:0051788	18	1	18204	50	CLU
4.832e-02	-3.03	receptor catabolic process	biological process	GO:0032801	18	1	18204	50	ZNRF3
4.832e-02	-3.03	regulation of extracellular matrix disassembly	biological process	GO:0010715	18	1	18204	50	CST3
4.832e-02	-3.03	myelin maintenance	biological process	GO:0043217	18	1	18204	50	CLU
4.832e-02	-3.03	negative regulation of platelet activation	biological process	GO:0010544	18	1	18204	50	PRKG1
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	positive regulation of myelination	biological process	GO:0031643	18	1	18204	50	PARD3
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.838e-02	-3.03	TYRKINASE	prints domains	PR00109	98	2	5227	19	ERBB4,FGFR3
4.839e-02	-3.03	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-non_chronically_sun_exposed_site-malignant_melanoma	COSMIC cancer mutations	skin-non_chronically_sun_exposed_site-malignant_melanoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	breast-carcinoma-neuroendocrine_carcinoma	COSMIC cancer mutations	breast-carcinoma-neuroendocrine_carcinoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-other-verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	skin-other-verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	non_chronically_sun_exposed_site	COSMIC cancer mutations	non_chronically_sun_exposed_site	17	1	16828	49	FGFR3
4.842e-02	-3.03	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	2	19454	50	NFIA,SOX5
4.843e-02	-3.03	organic acid transport	biological process	GO:0015849	298	3	18204	50	SLC1A2,SFXN5,SLC1A3
4.856e-02	-3.02	protein-folding chaperone binding	molecular function	GO:0051087	133	2	18094	48	CLU,ATP1A2
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.892e-02	-3.02	protein phosphorylation	biological process	GO:0006468	503	4	18204	50	BMPR1B,ERBB4,TNIK,PRKG1
4.893e-02	-3.02	phosphorylation	biological process	GO:0016310	729	5	18204	50	BMPR1B,FGFR3,ERBB4,TNIK,PRKG1
4.893e-02	-3.02	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	37	16828	49	ZBTB20,PARD3,NPAS3,ABLIM1,DTNA,RYR3,LSAMP,SFXN5,MAML2,TRPS1,SPARCL1,ATP1A2,GPM6A,ACSS1,CDH20,MACF1,PREX2,ERBB4,SORBS1,PTPRZ1,RORA,SLC1A2,LRIG1,TNIK,GPC5,CLU,SLC1A3,FBXL7,NHSL1,ATP13A4,FGFR3,NKAIN3,TRPM3,CTNND2,SOX5,PRKG1,RFX4
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.936e-02	-3.01	Alpha carbonic anhydrase	gene3d domains	3.10.200.10	17	1	14470	43	PTPRZ1
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	MACF1,DTNA,SORBS1
4.941e-02	-3.01	LRR_4	pfam domains	PF12799	18	1	17795	50	LRIG1
4.951e-02	-3.01	cellular response to organonitrogen compound	biological process	GO:0071417	505	4	18204	50	SLC1A2,SORBS1,RYR3,SLC1A3
4.962e-02	-3.00	ensheathment of neurons	biological process	GO:0007272	130	2	18204	50	CLU,PARD3
4.962e-02	-3.00	axon ensheathment	biological process	GO:0008366	130	2	18204	50	PARD3,CLU