Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.168e-09	-20.57	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	17	19454	50	ABLIM1,SLC4A4,ATP1A2,LSAMP,TRPS1,GJA1,GPM6A,AHCYL2,MSI2,SORBS1,NHSL1,CPE,SLC1A3,AQP4,MACF1,PTPRZ1,SPARCL1
6.200e-09	-18.90	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	45	16828	49	NEBL,SPON1,PARD3,MACF1,ZBTB20,CTNND2,SLC1A2,PTPRZ1,BMPR1B,FGFR3,PON2,NTM,NPAS3,ABLIM1,NFIA,NKAIN3,LSAMP,SOX5,TNIK,SLC4A4,ZNRF3,MEIS2,ATP13A4,NHSL1,PITPNC1,SFXN5,SORBS1,RFX4,MSI2,GPM6A,GPC5,LRIG1,CPE,FBXL7,SLC1A3,TRPS1,ITPR2,LIFR,CDH20,AHCYL2,PARD3B,RYR3,DTNA,SPARCL1,PREX2
9.497e-09	-18.47	brainstem	COSMIC cancer mutations	brainstem	3102	27	16828	49	TNIK,SOX5,PREX2,RYR3,LSAMP,ITPR2,LIFR,CDH20,AHCYL2,NKAIN3,NPAS3,FBXL7,SLC1A3,CPE,GPM6A,GPC5,SLC1A2,CTNND2,PTPRZ1,FGFR3,SFXN5,ZBTB20,PARD3,ATP13A4,ZNRF3,SPON1,MEIS2
1.086e-08	-18.34	cell periphery	cellular component	GO:0071944	6020	35	19108	49	FGFR3,CTNNA2,LSAMP,TNIK,ATP13A4,GLUL,SORBS1,SPON1,LRIG1,LIFR,AQP4,CPE,PARD3,SPARCL1,MACF1,ITPR2,ATP1A2,GJA1,GPC5,PON2,GPM6A,NTM,DTNA,CTNND2,RYR3,PREX2,NKAIN3,PARD3B,CDH20,PTPRZ1,SLC1A2,BMPR1B,SLC1A3,ZNRF3,SLC4A4
2.195e-08	-17.63	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	24	16828	49	SLC1A3,FBXL7,CPE,GPC5,GPM6A,PREX2,SOX5,TNIK,LSAMP,RYR3,NKAIN3,CDH20,AHCYL2,LIFR,ITPR2,PARD3,ATP13A4,MEIS2,SPON1,ZNRF3,PTPRZ1,CTNND2,SFXN5,ZBTB20
2.351e-08	-17.57	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	22	16828	49	GPC5,SPON1,GPM6A,LRIG1,ATP13A4,SLC1A3,PARD3,CPE,FBXL7,NPAS3,NHSL1,NKAIN3,AHCYL2,ITPR2,LSAMP,RYR3,BMPR1B,PREX2,RFX4,CTNND2,SOX5,SLC1A2
2.351e-08	-17.57	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	22	16828	49	LSAMP,RYR3,PREX2,SOX5,NKAIN3,AHCYL2,ITPR2,FBXL7,CPE,SLC1A3,NPAS3,GPC5,GPM6A,LRIG1,BMPR1B,RFX4,CTNND2,SLC1A2,NHSL1,ATP13A4,PARD3,SPON1
2.942e-08	-17.34	plasma membrane	cellular component	GO:0005886	5538	33	19108	49	SLC1A2,PTPRZ1,ZNRF3,SLC4A4,SLC1A3,BMPR1B,NKAIN3,CDH20,PARD3B,PREX2,NTM,GPM6A,RYR3,CTNND2,DTNA,GJA1,ATP1A2,PON2,GPC5,ITPR2,MACF1,CPE,AQP4,LIFR,LRIG1,PARD3,ATP13A4,LSAMP,TNIK,CTNNA2,FGFR3,SORBS1,GLUL
4.446e-08	-16.93	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	25	16828	49	LRIG1,GPM6A,GPC5,TRPS1,SLC1A3,FBXL7,CPE,NKAIN3,ITPR2,LIFR,RYR3,LSAMP,PARD3B,PREX2,SOX5,NEBL,MEIS2,ZNRF3,SPON1,ATP13A4,PARD3,SFXN5,RFX4,SLC1A2,CTNND2
8.941e-08	-16.23	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	3	10285	30	SLC1A3,GLUL,SLC1A2
8.941e-08	-16.23	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	3	10285	30	SLC1A2,GLUL,SLC1A3
1.027e-07	-16.09	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	24	16828	49	MEIS2,ZNRF3,SPON1,NEBL,PARD3,SFXN5,RFX4,SLC1A2,CTNND2,LRIG1,GPM6A,GPC5,TRPS1,FBXL7,CPE,SLC1A3,NKAIN3,ITPR2,LIFR,PREX2,SOX5,LSAMP,RYR3,PARD3B
1.086e-07	-16.04	lymph_node	COSMIC cancer mutations	lymph_node	1703	19	16828	49	ITPR2,LIFR,SFXN5,PARD3B,LSAMP,DTNA,RYR3,CTNND2,SOX5,TNIK,FGFR3,NEBL,GPC5,GPM6A,MEIS2,ATP13A4,PARD3,SLC1A3,TRPS1
1.245e-07	-15.90	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	9	19454	50	CTNNA2,NEBL,MACF1,DTNA,PARD3,NHSL1,SORBS1,TNIK,ABLIM1
1.551e-07	-15.68	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	39	16828	49	SLC1A2,CTNND2,RFX4,PTPRZ1,FGFR3,SORBS1,SFXN5,MACF1,ZBTB20,NHSL1,PITPNC1,PARD3,ATP13A4,SLC4A4,SPON1,MEIS2,NEBL,TNIK,SOX5,PREX2,PARD3B,RYR3,LSAMP,LIFR,ITPR2,AHCYL2,NKAIN3,NFIA,TRPS1,NPAS3,CPE,FBXL7,SLC1A3,ABLIM1,LRIG1,NTM,GPM6A,GPC5,PON2
2.803e-07	-15.09	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	29	16828	49	ATP13A4,PARD3,NEBL,SPON1,MEIS2,CTNND2,SLC1A2,FGFR3,MACF1,FBXL7,CPE,SLC1A3,TRPS1,GPM6A,GPC5,LSAMP,DTNA,RYR3,SOX5,SPARCL1,TNIK,PREX2,ATP1A2,ITPR2,LIFR,NKAIN3,AQP4,CDH20,AHCYL2
4.615e-07	-14.59	nervous system development	biological process	GO:0007399	2185	20	18204	50	TNIK,RFX4,BMPR1B,LSAMP,SOX5,PTPRZ1,CTNND2,CTNNA2,PARD3,SLC1A2,LRIG1,MEIS2,NTM,NFIA,GJA1,GPM6A,MSI2,ATP1A2,SLC1A3,PREX2
6.051e-07	-14.32	multicellular organism development	biological process	GO:0007275	3957	27	18204	50	NFIA,CPE,LRIG1,MEIS2,CTNNA2,TNIK,RFX4,LSAMP,SLC1A3,ZNRF3,PREX2,FGFR3,ATP1A2,GLUL,TRPS1,GJA1,GPM6A,NTM,SLC1A2,PARD3,NEBL,SOX5,BMPR1B,PTPRZ1,CTNND2,CDH20,MSI2
6.193e-07	-14.29	anatomical structure morphogenesis	biological process	GO:0009653	2225	20	18204	50	LRIG1,MEIS2,CPE,ABLIM1,NFIA,CTNND2,TNIK,NEBL,SOX5,PTPRZ1,BMPR1B,PARD3,CTNNA2,FGFR3,PREX2,SLC1A3,GJA1,GPM6A,GLUL,CDH20
1.129e-06	-13.69	system development	biological process	GO:0048731	3533	25	18204	50	NFIA,CPE,LRIG1,MEIS2,CTNNA2,TNIK,RFX4,LSAMP,SLC1A3,PREX2,FGFR3,ATP1A2,GLUL,TRPS1,GJA1,GPM6A,NTM,SLC1A2,PARD3,NEBL,PTPRZ1,BMPR1B,SOX5,CTNND2,MSI2
1.153e-06	-13.67	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	26	16828	49	RYR3,LSAMP,PREX2,TNIK,SPARCL1,SOX5,CDH20,AHCYL2,NKAIN3,AQP4,LIFR,ITPR2,ATP1A2,FBXL7,CPE,GPM6A,GPC5,FGFR3,SLC1A2,CTNND2,MACF1,ATP13A4,PARD3,NEBL,MEIS2,SPON1
1.475e-06	-13.43	cerebellum	COSMIC cancer mutations	cerebellum	769	12	16828	49	MEIS2,ITPR2,GPC5,NEBL,PTPRZ1,ABLIM1,NPAS3,CPE,CTNND2,PARD3,RYR3,PARD3B
1.990e-06	-13.13	cell morphogenesis	biological process	GO:0000902	687	11	18204	50	NFIA,SLC1A3,PREX2,PTPRZ1,BMPR1B,GPM6A,TNIK,CTNND2,CTNNA2,PARD3,CDH20
2.095e-06	-13.08	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	11	16828	49	NPAS3,CPE,PARD3,CTNND2,PTPRZ1,ABLIM1,PARD3B,RYR3,ITPR2,MEIS2,NEBL
2.127e-06	-13.06	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	11	16828	49	PARD3B,RYR3,CTNND2,PTPRZ1,ITPR2,NPAS3,CPE,PARD3,ABLIM1,NEBL,MEIS2
3.650e-06	-12.52	MAPT (microtubule associated protein tau)	protein interactions	4137	948	12	19454	50	CTNND2,TNIK,NTM,LSAMP,SORBS1,SLC1A2,ATP1A2,ABLIM1,CTNNA2,NEBL,GPM6A,SLC1A3
3.755e-06	-12.49	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	49	ZBTB20,PTPRZ1,BMPR1B,CTNND2,SLC1A2,MEIS2,SPON1,SLC4A4,NEBL,PARD3,ATP13A4,NKAIN3,ITPR2,LIFR,NFIA,PREX2,SOX5,TNIK,LSAMP,RYR3,GPC5,GPM6A,NTM,SLC1A3,FBXL7,CPE
3.755e-06	-12.49	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	26	16828	49	GPC5,GPM6A,NTM,FBXL7,CPE,SLC1A3,NKAIN3,ITPR2,LIFR,NFIA,PREX2,SOX5,TNIK,LSAMP,RYR3,MEIS2,SPON1,SLC4A4,NEBL,PARD3,ATP13A4,ZBTB20,PTPRZ1,BMPR1B,CTNND2,SLC1A2
4.001e-06	-12.43	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	14	16828	49	PARD3,FBXL7,NPAS3,NKAIN3,ATP1A2,NFIA,FGFR3,BMPR1B,PREX2,SOX5,SLC1A2,TNIK,RYR3,LSAMP
4.001e-06	-12.43	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	14	16828	49	LSAMP,RYR3,SOX5,SLC1A2,TNIK,PREX2,FGFR3,BMPR1B,NFIA,ATP1A2,NKAIN3,FBXL7,PARD3,NPAS3
6.091e-06	-12.01	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	19	16828	49	SOX5,CTNND2,SLC1A2,PTPRZ1,PREX2,FGFR3,RYR3,LSAMP,ITPR2,NKAIN3,CDH20,PARD3,FBXL7,SLC1A3,SPON1,GPM6A,GPC5,MEIS2,NEBL
7.143e-06	-11.85	Par3/HAL_N	interpro domains	IPR021922	2	2	18521	50	PARD3B,PARD3
7.737e-06	-11.77	Par3_HAL_N_term	pfam domains	PF12053	2	2	17795	50	PARD3B,PARD3
8.240e-06	-11.71	adherens junction	cellular component	GO:0005912	188	6	19108	49	CTNNA2,SORBS1,CDH20,PARD3B,CTNND2,PARD3
1.014e-05	-11.50	generation of neurons	biological process	GO:0048699	1158	13	18204	50	NTM,NFIA,CTNNA2,PARD3,TNIK,BMPR1B,SOX5,PTPRZ1,CTNND2,SLC1A3,PREX2,GJA1,GPM6A
1.071e-05	-11.44	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	44	16828	49	PON2,NTM,ABLIM1,NPAS3,NFIA,NKAIN3,ATP1A2,LSAMP,TNIK,SOX5,NEBL,SPON1,GLUL,PARD3,ZBTB20,MACF1,PTPRZ1,BMPR1B,FGFR3,SLC1A2,CTNND2,LRIG1,GPC5,GPM6A,TRPS1,SLC1A3,FBXL7,CPE,CDH20,AHCYL2,LIFR,ITPR2,DTNA,RYR3,PARD3B,PREX2,MEIS2,SLC4A4,ZNRF3,ATP13A4,PITPNC1,SORBS1,SFXN5,RFX4
1.071e-05	-11.44	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	44	16828	49	RFX4,PITPNC1,SORBS1,SFXN5,ATP13A4,ZNRF3,SLC4A4,MEIS2,PARD3B,RYR3,DTNA,PREX2,LIFR,ITPR2,AHCYL2,CDH20,TRPS1,CPE,FBXL7,SLC1A3,LRIG1,GPM6A,GPC5,SLC1A2,CTNND2,PTPRZ1,FGFR3,BMPR1B,MACF1,ZBTB20,GLUL,PARD3,NEBL,SPON1,LSAMP,TNIK,SOX5,NFIA,ATP1A2,NKAIN3,NPAS3,ABLIM1,PON2,NTM
1.311e-05	-11.24	anatomical structure development	biological process	GO:0048856	5207	29	18204	50	CDH20,MSI2,PARD3,NEBL,SOX5,BMPR1B,PTPRZ1,CTNND2,NTM,ABLIM1,SLC1A2,GLUL,GJA1,TRPS1,GPM6A,SLC1A3,SPARCL1,PREX2,ZNRF3,FGFR3,ATP1A2,CTNNA2,TNIK,LSAMP,RFX4,NFIA,CPE,LRIG1,MEIS2
1.324e-05	-11.23	multicellular organismal process	biological process	GO:0032501	6177	32	18204	50	FGFR3,ATP1A2,SLC1A3,AQP4,ZNRF3,PREX2,TRPS1,GJA1,GPM6A,GLUL,CPE,LRIG1,MEIS2,NFIA,TNIK,LSAMP,RFX4,CTNNA2,MSI2,RYR3,CDH20,SLC1A2,NTM,DTNA,ABLIM1,NEBL,SLC4A4,SOX5,BMPR1B,PTPRZ1,CTNND2,PARD3
1.886e-05	-10.88	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	35	16828	49	LRIG1,NTM,GPM6A,GPC5,TRPS1,FBXL7,ABLIM1,ITPR2,ATP1A2,CDH20,TNIK,SOX5,PREX2,PARD3B,RYR3,LSAMP,DTNA,ZNRF3,SLC4A4,SPON1,NEBL,PARD3,ATP13A4,GLUL,SORBS1,SFXN5,MACF1,ZBTB20,NHSL1,PITPNC1,SLC1A2,CTNND2,RFX4,FGFR3,PTPRZ1
2.020e-05	-10.81	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	9	16828	49	CTNND2,SOX5,LSAMP,RYR3,GPM6A,GPC5,NKAIN3,SFXN5,AHCYL2
2.057e-05	-10.79	cell junction	cellular component	GO:0030054	2224	17	19108	49	NFIA,PARD3,CTNNA2,GPM6A,FGFR3,TNIK,CTNND2,DTNA,SORBS1,PTPRZ1,GJA1,ATP1A2,SLC1A2,SLC1A3,SPARCL1,PARD3B,CDH20
2.257e-05	-10.70	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	10	18094	48	RYR3,ATP13A4,ITPR2,GPM6A,GJA1,SFXN5,SLC1A2,SLC4A4,ATP1A2,SLC1A3
2.260e-05	-10.70	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	18	16828	49	NEBL,MEIS2,GPM6A,GPC5,SPON1,FBXL7,SLC1A3,PARD3,NKAIN3,CDH20,ITPR2,LSAMP,RYR3,PTPRZ1,PREX2,CTNND2,SOX5,SLC1A2
2.260e-05	-10.70	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	18	16828	49	CTNND2,SOX5,SLC1A2,PREX2,PTPRZ1,RYR3,LSAMP,ITPR2,NKAIN3,CDH20,PARD3,FBXL7,SLC1A3,SPON1,GPC5,GPM6A,MEIS2,NEBL
2.773e-05	-10.49	developmental process	biological process	GO:0032502	5716	30	18204	50	GLUL,TRPS1,GJA1,GPM6A,SPARCL1,NHSL1,PREX2,ZNRF3,SLC1A3,ATP1A2,FGFR3,CTNNA2,TNIK,LSAMP,RFX4,NFIA,LRIG1,MEIS2,CPE,CDH20,MSI2,PARD3,CTNND2,NEBL,SOX5,PTPRZ1,BMPR1B,ABLIM1,NTM,SLC1A2
2.893e-05	-10.45	pharynx	COSMIC cancer mutations	pharynx	2696	20	16828	49	SLC4A4,GPC5,ATP13A4,NPAS3,NFIA,NHSL1,PITPNC1,MACF1,SORBS1,SFXN5,ATP1A2,RYR3,DTNA,PARD3B,RFX4,FGFR3,PTPRZ1,PREX2,SLC1A2,CTNND2
2.973e-05	-10.42	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	47	16828	49	MEIS2,SLC4A4,ZNRF3,ATP13A4,SFXN5,SORBS1,PITPNC1,NHSL1,RFX4,GPC5,GPM6A,LRIG1,MSI2,SLC1A3,FBXL7,CPE,TRPS1,CDH20,AHCYL2,ITPR2,LIFR,PREX2,SPARCL1,DTNA,RYR3,PARD3B,SPON1,NEBL,PARD3,ZBTB20,MACF1,FGFR3,PTPRZ1,BMPR1B,CTNND2,SLC1A2,NTM,PON2,ABLIM1,NPAS3,NKAIN3,AQP4,ATP1A2,NFIA,SOX5,TNIK,LSAMP
3.970e-05	-10.13	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	23	16828	49	PARD3,MEIS2,SPON1,SLC4A4,ZNRF3,PTPRZ1,BMPR1B,CTNND2,PITPNC1,MACF1,SLC1A3,CPE,FBXL7,NPAS3,GPC5,MSI2,PREX2,TNIK,DTNA,RYR3,LSAMP,PARD3B,LIFR
3.970e-05	-10.13	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	23	16828	49	LIFR,RYR3,LSAMP,DTNA,PARD3B,PREX2,TNIK,MSI2,GPC5,NPAS3,SLC1A3,FBXL7,CPE,PITPNC1,MACF1,BMPR1B,PTPRZ1,CTNND2,MEIS2,ZNRF3,SLC4A4,SPON1,PARD3
3.982e-05	-10.13	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	31	16828	49	PARD3,NEBL,MEIS2,ZNRF3,SPON1,PTPRZ1,FGFR3,SLC1A2,GJA1,CTNND2,NHSL1,MACF1,SORBS1,TRPS1,NPAS3,FBXL7,SLC1A3,PON2,GPC5,GPM6A,LSAMP,RYR3,PARD3B,PREX2,SPARCL1,SOX5,NFIA,CDH20,AQP4,NKAIN3,ITPR2
4.105e-05	-10.10	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	33	16828	49	ATP1A2,ITPR2,LIFR,AQP4,SOX5,SPARCL1,TNIK,PREX2,PARD3B,RYR3,GPM6A,GPC5,FBXL7,CPE,TRPS1,NPAS3,ABLIM1,SFXN5,SORBS1,MACF1,PITPNC1,ZBTB20,CTNND2,BMPR1B,FGFR3,PTPRZ1,SPON1,SLC4A4,MEIS2,NEBL,PARD3,ATP13A4,GLUL
4.376e-05	-10.04	cell-cell junction	cellular component	GO:0005911	513	8	19108	49	PARD3,GJA1,ATP1A2,PARD3B,CTNND2,CDH20,SORBS1,CTNNA2
4.540e-05	-10.00	neurogenesis	biological process	GO:0022008	1334	13	18204	50	GPM6A,GJA1,SLC1A3,PREX2,PTPRZ1,SOX5,BMPR1B,TNIK,CTNND2,CTNNA2,PARD3,NFIA,NTM
4.882e-05	-9.93	neuron projection morphogenesis	biological process	GO:0048812	486	8	18204	50	PARD3,CTNNA2,CTNND2,TNIK,BMPR1B,PTPRZ1,GPM6A,PREX2
5.246e-05	-9.86	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	8	18204	50	PREX2,CTNNA2,PARD3,TNIK,BMPR1B,GPM6A,PTPRZ1,CTNND2
5.502e-05	-9.81	monoatomic ion transmembrane transport	biological process	GO:0034220	804	10	18204	50	GPM6A,GJA1,SLC4A4,RYR3,SFXN5,SLC1A2,ATP1A2,ATP13A4,SLC1A3,ITPR2
5.590e-05	-9.79	transporter activity	molecular function	GO:0005215	1211	12	18094	48	PITPNC1,GJA1,SFXN5,ATP13A4,SLC4A4,SLC1A3,ATP1A2,SLC1A2,GPM6A,AQP4,RYR3,ITPR2
5.634e-05	-9.78	cell projection morphogenesis	biological process	GO:0048858	496	8	18204	50	PARD3,CTNNA2,CTNND2,TNIK,GPM6A,PTPRZ1,BMPR1B,PREX2
5.762e-05	-9.76	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	10	16828	49	PREX2,SLC1A2,FBXL7,PARD3,SOX5,LSAMP,RYR3,NKAIN3,ATP1A2,GPC5
6.287e-05	-9.67	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	8	16828	49	CTNND2,ATP13A4,LSAMP,RYR3,GPM6A,GPC5,MEIS2,SFXN5
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A3,SLC1A2
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A2,SLC1A3
6.922e-05	-9.58	plasma membrane region	cellular component	GO:0098590	1278	12	19108	49	GPM6A,TNIK,MACF1,PARD3B,SORBS1,ATP1A2,GJA1,AQP4,SLC1A2,PARD3,SLC1A3,SLC4A4
7.145e-05	-9.55	nodular	COSMIC cancer mutations	nodular	1515	14	16828	49	ATP1A2,CDH20,MACF1,CTNND2,SPARCL1,PREX2,FGFR3,PTPRZ1,SLC4A4,NEBL,NPAS3,CPE,ABLIM1,ATP13A4
7.355e-05	-9.52	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	50	SLC1A3,SLC1A2
7.355e-05	-9.52	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	50	SLC1A2,SLC1A3
7.513e-05	-9.50	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	50	SLC1A3,SLC1A2,ATP1A2
7.567e-05	-9.49	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	14	16828	49	SPON1,GPC5,MEIS2,NEBL,SLC1A3,PARD3,FBXL7,ITPR2,NKAIN3,SOX5,CTNND2,PREX2,RYR3,LSAMP
7.567e-05	-9.49	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	14	16828	49	ITPR2,NKAIN3,SOX5,CTNND2,PREX2,RYR3,LSAMP,SPON1,GPC5,MEIS2,NEBL,PARD3,SLC1A3,FBXL7
7.798e-05	-9.46	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	30	16828	49	SOX5,PARD3B,LSAMP,RYR3,DTNA,ITPR2,LIFR,ATP1A2,CDH20,AHCYL2,NKAIN3,NPAS3,TRPS1,FBXL7,SLC1A3,LRIG1,NTM,GPM6A,GPC5,CTNND2,PTPRZ1,SORBS1,MACF1,PARD3,ATP13A4,SLC4A4,ZNRF3,SPON1,MEIS2,NEBL
7.798e-05	-9.46	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	30	16828	49	SORBS1,MACF1,CTNND2,PTPRZ1,ZNRF3,SLC4A4,SPON1,MEIS2,NEBL,PARD3,ATP13A4,ITPR2,LIFR,ATP1A2,AHCYL2,CDH20,NKAIN3,SOX5,PARD3B,RYR3,DTNA,LSAMP,NTM,LRIG1,GPC5,GPM6A,NPAS3,TRPS1,SLC1A3,FBXL7
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	NTM,LSAMP,GPM6A
9.059e-05	-9.31	vascular transport	biological process	GO:0010232	86	4	18204	50	SLC1A3,ATP1A2,SLC4A4,SLC1A2
9.059e-05	-9.31	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	50	SLC1A3,ATP1A2,SLC1A2,SLC4A4
9.194e-05	-9.29	cell junction organization	biological process	GO:0034330	532	8	18204	50	CTNND2,GPM6A,SORBS1,GJA1,CDH20,PARD3,SPARCL1,NFIA
9.559e-05	-9.26	neuron development	biological process	GO:0048666	859	10	18204	50	NTM,SLC1A3,PREX2,CTNNA2,PARD3,BMPR1B,PTPRZ1,GPM6A,TNIK,CTNND2
9.700e-05	-9.24	EPHA4 (EPH receptor A4)	protein interactions	2043	180	5	19454	50	FGFR3,AHCYL2,PARD3,GJA1,CTNNA2
1.012e-04	-9.20	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	25	16828	49	NFIA,LIFR,ITPR2,CDH20,PARD3B,RYR3,TNIK,SOX5,PREX2,LRIG1,NTM,GPM6A,TRPS1,FBXL7,MACF1,ZBTB20,NHSL1,SORBS1,CTNND2,RFX4,PTPRZ1,FGFR3,SLC4A4,ATP13A4,PARD3
1.064e-04	-9.15	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	2	18521	50	ITPR2,RYR3
1.064e-04	-9.15	RIH_assoc-dom	interpro domains	IPR013662	6	2	18521	50	ITPR2,RYR3
1.064e-04	-9.15	Ins145_P3_rcpt	interpro domains	IPR014821	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	RIH_dom	interpro domains	IPR000699	6	2	18521	50	RYR3,ITPR2
1.080e-04	-9.13	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	24	16828	49	FBXL7,TRPS1,NPAS3,GPM6A,TNIK,PREX2,PARD3B,RYR3,ATP1A2,AQP4,NFIA,PARD3,SLC4A4,ZNRF3,NEBL,CTNND2,GJA1,SLC1A2,PTPRZ1,FGFR3,RFX4,MACF1,NHSL1,PITPNC1
1.101e-04	-9.11	D-amino acid transport	biological process	GO:0042940	6	2	18204	50	SLC1A2,SLC1A3
1.101e-04	-9.11	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	50	SLC1A2,SLC1A3
1.152e-04	-9.07	Ins145_P3_rec	pfam domains	PF08709	6	2	17795	50	RYR3,ITPR2
1.152e-04	-9.07	RIH_assoc	pfam domains	PF08454	6	2	17795	50	RYR3,ITPR2
1.152e-04	-9.07	RYDR_ITPR	pfam domains	PF01365	6	2	17795	50	ITPR2,RYR3
1.158e-04	-9.06	glial cell projection	cellular component	GO:0097386	37	3	19108	49	GLUL,AQP4,SLC1A2
1.167e-04	-9.06	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	4	19454	50	GJA1,SORBS1,PARD3,FGFR3
1.217e-04	-9.01	transmembrane transporter activity	molecular function	GO:0022857	1110	11	18094	48	GJA1,SFXN5,ATP13A4,SLC4A4,ATP1A2,SLC1A3,SLC1A2,GPM6A,AQP4,RYR3,ITPR2
1.219e-04	-9.01	tibia	COSMIC cancer mutations	tibia	836	10	16828	49	NKAIN3,GPM6A,MACF1,ABLIM1,FGFR3,PREX2,CTNND2,CPE,TNIK,LSAMP
1.345e-04	-8.91	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	2	14470	44	ITPR2,RYR3
1.349e-04	-8.91	neuron differentiation	biological process	GO:0030182	1081	11	18204	50	NFIA,NTM,CTNND2,PTPRZ1,BMPR1B,TNIK,PARD3,CTNNA2,PREX2,SLC1A3,GPM6A
1.374e-04	-8.89	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	6	19454	50	TNIK,PARD3,ABLIM1,AHCYL2,DTNA,MACF1
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A3,SLC1A2
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A3,SLC1A2
1.534e-04	-8.78	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	7	18094	48	SLC4A4,ATP1A2,SLC1A3,SLC1A2,GPM6A,RYR3,ITPR2
1.610e-04	-8.73	SDF	pfam domains	PF00375	7	2	17795	50	SLC1A2,SLC1A3
1.625e-04	-8.72	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	34	16828	49	NTM,LRIG1,FBXL7,NPAS3,TRPS1,ATP1A2,LIFR,ITPR2,AQP4,CDH20,NFIA,SOX5,PREX2,PARD3B,LSAMP,RYR3,SPON1,SLC4A4,ZNRF3,MEIS2,NEBL,PARD3,ATP13A4,GLUL,SFXN5,MACF1,PITPNC1,NHSL1,ZBTB20,CTNND2,SLC1A2,FGFR3,PTPRZ1,RFX4
1.625e-04	-8.72	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	34	16828	49	MACF1,ZBTB20,NHSL1,PITPNC1,SFXN5,SLC1A2,CTNND2,RFX4,FGFR3,PTPRZ1,NEBL,SLC4A4,ZNRF3,SPON1,MEIS2,ATP13A4,GLUL,PARD3,NFIA,LIFR,ITPR2,ATP1A2,CDH20,AQP4,PARD3B,LSAMP,RYR3,SOX5,PREX2,LRIG1,NTM,TRPS1,NPAS3,FBXL7
1.627e-04	-8.72	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	5	19454	50	RYR3,GJA1,PARD3,ATP1A2,DTNA
1.628e-04	-8.72	humerus	COSMIC cancer mutations	humerus	546	8	16828	49	GPC5,GPM6A,AHCYL2,NKAIN3,SFXN5,NEBL,SOX5,PARD3B
1.662e-04	-8.70	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	50	RYR3,SLC1A3,SLC1A2
1.841e-04	-8.60	beta-catenin binding	molecular function	GO:0008013	107	4	18094	48	CTNNA2,CTNND2,CDH20,GJA1
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	LSAMP,NKAIN3,CTNND2,GPM6A
1.879e-04	-8.58	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	44	SLC1A2,SLC1A3
1.949e-04	-8.54	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	7	18204	50	SLC1A3,PREX2,CTNNA2,PARD3,BMPR1B,PTPRZ1,CTNND2
2.037e-04	-8.50	cell adhesion	biological process	GO:0007155	942	10	18204	50	CTNND2,SPON1,SORBS1,LSAMP,PARD3B,PARD3,CDH20,CTNNA2,SPARCL1,NTM
2.071e-04	-8.48	cellular response to endogenous stimulus	biological process	GO:0071495	1135	11	18204	50	BMPR1B,SOX5,SORBS1,GJA1,RYR3,ATP1A2,SLC1A2,FGFR3,ITPR2,NFIA,SLC1A3
2.276e-04	-8.39	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	8	18094	48	SLC1A2,SLC1A3,ATP1A2,SLC4A4,ITPR2,ATP13A4,RYR3,GPM6A
2.282e-04	-8.39	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	6	16828	49	SOX5,GPM6A,GPC5,NKAIN3,SFXN5,AHCYL2
2.300e-04	-8.38	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	45	16828	49	MACF1,ZBTB20,CTNND2,SLC1A2,GJA1,FGFR3,BMPR1B,PTPRZ1,NEBL,SPON1,GLUL,PARD3,NFIA,ATP1A2,LSAMP,SOX5,TNIK,PON2,NTM,NPAS3,ABLIM1,NHSL1,PITPNC1,SFXN5,SORBS1,RFX4,SLC4A4,ZNRF3,MEIS2,ATP13A4,ITPR2,LIFR,CDH20,PARD3B,DTNA,RYR3,SPARCL1,PREX2,GPC5,GPM6A,LRIG1,FBXL7,SLC1A3,CPE,TRPS1
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	NTM,LSAMP
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	LSAMP,NTM
2.328e-04	-8.37	cervix	COSMIC cancer mutations	cervix	11793	45	16828	49	TRPS1,SLC1A3,CPE,FBXL7,LRIG1,GPM6A,GPC5,DTNA,RYR3,PARD3B,PREX2,SPARCL1,CDH20,LIFR,ITPR2,ATP13A4,MEIS2,ZNRF3,SLC4A4,RFX4,PITPNC1,NHSL1,SORBS1,SFXN5,ABLIM1,NPAS3,PON2,NTM,LSAMP,TNIK,SOX5,NFIA,ATP1A2,GLUL,PARD3,NEBL,SPON1,FGFR3,BMPR1B,PTPRZ1,GJA1,SLC1A2,CTNND2,ZBTB20,MACF1
2.370e-04	-8.35	RHOB (ras homolog family member B)	protein interactions	388	832	9	19454	50	AHCYL2,DTNA,PARD3B,SLC1A3,MACF1,ABLIM1,GJA1,TNIK,PARD3
2.454e-04	-8.31	monoatomic ion transport	biological process	GO:0006811	964	10	18204	50	SLC4A4,GJA1,GPM6A,SFXN5,RYR3,ATP1A2,SLC1A2,ITPR2,SLC1A3,ATP13A4
2.464e-04	-8.31	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	4	10285	30	SLC4A4,SLC1A2,AHCYL2,SLC1A3
2.531e-04	-8.28	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	12	16828	49	NEBL,ATP13A4,ABLIM1,NPAS3,CPE,MACF1,CDH20,ATP1A2,PREX2,PTPRZ1,SPARCL1,CTNND2
2.551e-04	-8.27	acidic amino acid transport	biological process	GO:0015800	45	3	18204	50	GJA1,SLC1A2,SLC1A3
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	44	SLC1A3,SLC1A2
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	44	SLC1A3,SLC1A2
2.833e-04	-8.17	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	35	16828	49	NHSL1,MACF1,SFXN5,BMPR1B,FGFR3,PTPRZ1,RFX4,CTNND2,SLC1A2,NEBL,MEIS2,SPON1,SLC4A4,ATP13A4,PARD3,NKAIN3,CDH20,AHCYL2,ATP1A2,ITPR2,LIFR,LSAMP,RYR3,PREX2,SOX5,TNIK,PON2,GPM6A,GPC5,LRIG1,ABLIM1,FBXL7,SLC1A3,CPE,TRPS1
2.855e-04	-8.16	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	15	16828	49	GPM6A,ZNRF3,SLC4A4,NEBL,NPAS3,ITPR2,AHCYL2,MACF1,ZBTB20,SOX5,TNIK,FGFR3,BMPR1B,PARD3B,RYR3
2.887e-04	-8.15	larynx	COSMIC cancer mutations	larynx	1948	15	16828	49	TNIK,SOX5,BMPR1B,FGFR3,PARD3B,RYR3,ITPR2,AHCYL2,MACF1,ZBTB20,NPAS3,ZNRF3,SLC4A4,GPM6A,NEBL
2.894e-04	-8.15	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	23	16828	49	RYR3,PARD3B,RFX4,PTPRZ1,PREX2,FGFR3,SLC1A2,GJA1,TNIK,CTNND2,NFIA,PITPNC1,MACF1,AQP4,ATP1A2,TRPS1,NPAS3,FBXL7,PARD3,NEBL,ZNRF3,SLC4A4,GPM6A
2.903e-04	-8.14	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	17	16828	49	PREX2,FGFR3,SPARCL1,RYR3,PARD3B,SORBS1,CDH20,NHSL1,NFIA,MACF1,SLC1A3,PARD3,TRPS1,NPAS3,SPON1,ZNRF3,PON2
2.903e-04	-8.14	alveolar	COSMIC cancer mutations	alveolar	2414	17	16828	49	PON2,ZNRF3,SPON1,TRPS1,NPAS3,SLC1A3,PARD3,NHSL1,NFIA,MACF1,CDH20,SORBS1,RYR3,PARD3B,FGFR3,PREX2,SPARCL1
2.905e-04	-8.14	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	23	16828	49	NPAS3,TRPS1,FBXL7,GPM6A,PREX2,TNIK,RYR3,PARD3B,AQP4,ATP1A2,NFIA,PARD3,ZNRF3,SLC4A4,NEBL,RFX4,FGFR3,PTPRZ1,GJA1,SLC1A2,CTNND2,PITPNC1,MACF1
2.945e-04	-8.13	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	6	19454	50	TNIK,NEBL,GJA1,SORBS1,PARD3,MACF1
2.958e-04	-8.13	Glutamatergic synapse	KEGG pathways	hsa04724	114	4	7161	21	SLC1A2,ITPR2,SLC1A3,GLUL
2.958e-04	-8.13	Glutamatergic synapse	KEGG pathways	ko04724	114	4	7161	21	SLC1A3,GLUL,SLC1A2,ITPR2
3.162e-04	-8.06	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	4	19454	50	PARD3,DTNA,ABLIM1,MACF1
3.170e-04	-8.06	MIR_motif	interpro domains	IPR016093	10	2	18521	50	ITPR2,RYR3
3.170e-04	-8.06	MIR_dom_sf	interpro domains	IPR036300	10	2	18521	50	ITPR2,RYR3
3.190e-04	-8.05	EDTRNSPORT	prints domains	PR00173	7	2	5227	21	SLC1A2,SLC1A3
3.220e-04	-8.04	response to endogenous stimulus	biological process	GO:0009719	1402	12	18204	50	NFIA,MEIS2,SLC1A2,SORBS1,BMPR1B,SOX5,ITPR2,SLC1A3,ATP1A2,FGFR3,RYR3,GJA1
3.272e-04	-8.02	striated muscle contraction	biological process	GO:0006941	120	4	18204	50	RYR3,DTNA,GJA1,ATP1A2
3.281e-04	-8.02	establishment of centrosome localization	biological process	GO:0051660	10	2	18204	50	PARD3,PARD3B
3.281e-04	-8.02	cellular response to cocaine	biological process	GO:0071314	10	2	18204	50	SLC1A2,SLC1A3
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	RYR3,SLC1A2,SOX5,PREX2
3.432e-04	-7.98	MIR	pfam domains	PF02815	10	2	17795	50	ITPR2,RYR3
3.648e-04	-7.92	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	2	10285	30	SLC4A4,AHCYL2
3.702e-04	-7.90	EZR (ezrin)	protein interactions	7430	526	7	19454	50	NEBL,MACF1,DTNA,AHCYL2,SORBS1,TNIK,ABLIM1
4.003e-04	-7.82	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	50	SLC1A3,SLC1A2
4.003e-04	-7.82	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	50	SLC1A2,SLC1A3
4.146e-04	-7.79	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	50	BMPR1B,SOX5,TRPS1
4.185e-04	-7.78	anchoring junction	cellular component	GO:0070161	902	9	19108	49	CTNNA2,FGFR3,CDH20,SORBS1,PARD3B,CTNND2,GJA1,ATP1A2,PARD3
4.352e-04	-7.74	mouth	COSMIC cancer mutations	mouth	9004	38	16828	49	CDH20,ITPR2,LIFR,ATP1A2,PREX2,TNIK,SOX5,DTNA,RYR3,LSAMP,PARD3B,NTM,LRIG1,GPM6A,GPC5,ABLIM1,NPAS3,TRPS1,SLC1A3,FBXL7,SORBS1,SFXN5,ZBTB20,NHSL1,PITPNC1,MACF1,RFX4,FGFR3,PTPRZ1,SLC1A2,CTNND2,SLC4A4,ZNRF3,SPON1,NEBL,PARD3,GLUL,ATP13A4
4.404e-04	-7.73	Ig_I-set	interpro domains	IPR013098	132	4	18521	50	FGFR3,LSAMP,LRIG1,NTM
4.673e-04	-7.67	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	15	16828	49	NEBL,MSI2,ZNRF3,GPM6A,GPC5,TRPS1,PARD3,ABLIM1,MACF1,ITPR2,AQP4,LSAMP,PTPRZ1,FGFR3,PREX2
4.698e-04	-7.66	amino acid transport	biological process	GO:0006865	132	4	18204	50	SLC1A2,GJA1,SLC1A3,SFXN5
4.778e-04	-7.65	sarcolemma	cellular component	GO:0042383	142	4	19108	49	AQP4,ATP1A2,RYR3,DTNA
4.895e-04	-7.62	trunk	COSMIC cancer mutations	trunk	3554	21	16828	49	LSAMP,RYR3,PREX2,PTPRZ1,FGFR3,CTNND2,SPARCL1,SOX5,MACF1,CDH20,LIFR,ATP1A2,ATP13A4,ABLIM1,NPAS3,TRPS1,PARD3,SLC1A3,CPE,NEBL,MEIS2
5.060e-04	-7.59	cell body	cellular component	GO:0044297	556	7	19108	49	GPM6A,CTNND2,GLUL,ATP1A2,SLC1A2,BMPR1B,SLC1A3
5.115e-04	-7.58	I-set	pfam domains	PF07679	132	4	17795	50	NTM,LSAMP,FGFR3,LRIG1
5.139e-04	-7.57	visual behavior	biological process	GO:0007632	57	3	18204	50	MEIS2,ATP1A2,SLC1A2
5.199e-04	-7.56	CTNNB1 (catenin beta 1)	protein interactions	1499	926	9	19454	50	NHSL1,PARD3,SORBS1,GJA1,CTNND2,PARD3B,PTPRZ1,DTNA,CTNNA2
5.223e-04	-7.56	transmembrane transport	biological process	GO:0055085	1264	11	18204	50	ATP1A2,SLC1A2,ITPR2,AQP4,SLC1A3,ATP13A4,SLC4A4,GJA1,GPM6A,SFXN5,RYR3
5.266e-04	-7.55	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	8	18094	48	ITPR2,RYR3,AQP4,GPM6A,SLC1A2,ATP1A2,SLC1A3,SLC4A4
5.403e-04	-7.52	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	8	10285	30	RYR3,ATP1A2,AQP4,AHCYL2,SLC1A3,SLC4A4,SLC1A2,ATP13A4
5.442e-04	-7.52	NAKATPASE	prints domains	PR00121	9	2	5227	21	ATP13A4,ATP1A2
5.522e-04	-7.50	neuron projection development	biological process	GO:0031175	693	8	18204	50	PREX2,PARD3,CTNNA2,CTNND2,PTPRZ1,BMPR1B,GPM6A,TNIK
5.593e-04	-7.49	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	3	10285	30	ITPR2,RYR3,ATP1A2
5.629e-04	-7.48	MIR	prosite domains	PS50919	10	2	12186	44	RYR3,ITPR2
5.976e-04	-7.42	export across plasma membrane	biological process	GO:0140115	60	3	18204	50	GJA1,SLC4A4,ATP1A2
6.089e-04	-7.40	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	40	16828	49	NEBL,MEIS2,ZNRF3,SLC4A4,SPON1,ATP13A4,PARD3,PITPNC1,MACF1,SORBS1,RFX4,BMPR1B,FGFR3,PTPRZ1,GJA1,CTNND2,MSI2,NTM,LRIG1,GPM6A,GPC5,ABLIM1,NPAS3,TRPS1,FBXL7,CPE,NFIA,AHCYL2,CDH20,NKAIN3,ITPR2,LIFR,ATP1A2,DTNA,RYR3,PARD3B,PREX2,TNIK,SOX5,SPARCL1
6.144e-04	-7.39	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	33	16828	49	ATP13A4,PARD3,NEBL,SPON1,MEIS2,CTNND2,SLC1A2,BMPR1B,PTPRZ1,RFX4,MACF1,NHSL1,SFXN5,CPE,FBXL7,SLC1A3,ABLIM1,PON2,GPC5,GPM6A,LRIG1,PARD3B,RYR3,LSAMP,SPARCL1,SOX5,TNIK,PREX2,ITPR2,LIFR,NKAIN3,CDH20,AHCYL2
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A3,SLC1A2
6.176e-04	-7.39	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	40	16828	49	PARD3,ATP13A4,MEIS2,SPON1,ZNRF3,SLC4A4,NEBL,BMPR1B,FGFR3,PTPRZ1,RFX4,CTNND2,GJA1,SORBS1,PITPNC1,MACF1,ABLIM1,CPE,FBXL7,TRPS1,NPAS3,GPM6A,GPC5,NTM,LRIG1,MSI2,PREX2,SPARCL1,SOX5,TNIK,RYR3,DTNA,PARD3B,NKAIN3,CDH20,AHCYL2,ATP1A2,LIFR,ITPR2,NFIA
6.239e-04	-7.38	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	12	16828	49	SLC4A4,ATP13A4,NFIA,PITPNC1,NHSL1,ATP1A2,SFXN5,CTNND2,SLC1A2,FGFR3,PREX2,RFX4
6.239e-04	-7.38	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	12	16828	49	ATP13A4,SLC4A4,SLC1A2,CTNND2,RFX4,PREX2,FGFR3,ATP1A2,SFXN5,NFIA,PITPNC1,NHSL1
6.388e-04	-7.36	CDH1 (cadherin 1)	protein interactions	999	757	8	19454	50	MACF1,NEBL,CTNNA2,ABLIM1,CTNND2,SORBS1,NHSL1,PARD3
6.556e-04	-7.33	Ig_3	pfam domains	PF13927	141	4	17795	50	LRIG1,NTM,FGFR3,LSAMP
6.570e-04	-7.33	MIR	smart domains	SM00472	10	2	9717	38	RYR3,ITPR2
6.588e-04	-7.33	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	50	ATP1A2,SLC4A4
6.642e-04	-7.32	ACTB (actin beta)	protein interactions	60	958	9	19454	50	ABLIM1,SFXN5,SORBS1,NHSL1,DTNA,AHCYL2,MACF1,NEBL,MEIS2
6.654e-04	-7.32	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	2	19454	50	PARD3,TNIK
6.850e-04	-7.29	scalp	COSMIC cancer mutations	scalp	2110	15	16828	49	SOX5,FGFR3,PTPRZ1,PREX2,LSAMP,ATP1A2,SORBS1,MACF1,NFIA,TRPS1,ATP13A4,SLC4A4,NTM,GPC5,NEBL
6.989e-04	-7.27	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	5	18094	48	SLC1A3,SFXN5,GJA1,SLC4A4,SLC1A2
7.220e-04	-7.23	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	50	CTNNA2,PREX2,CTNND2
7.592e-04	-7.18	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	2	19454	50	CPE,MACF1
7.721e-04	-7.17	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	5	18094	48	SLC1A3,ATP1A2,SLC4A4,ATP13A4,SLC1A2
7.916e-04	-7.14	face	COSMIC cancer mutations	face	2139	15	16828	49	ITPR2,AQP4,MACF1,PREX2,PTPRZ1,FGFR3,LSAMP,GPM6A,GPC5,ZNRF3,NEBL,MSI2,PARD3,TRPS1,ABLIM1
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	SLC4A4,SLC1A3,ATP1A2,SLC1A2
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	ZBTB20,LSAMP
8.309e-04	-7.09	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	5	19454	50	GJA1,SORBS1,PARD3,DTNA,PARD3B
8.340e-04	-7.09	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	11	16828	49	MACF1,RYR3,TNIK,CTNND2,FGFR3,NEBL,NTM,GPM6A,ATP13A4,TRPS1,ABLIM1
8.340e-04	-7.09	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	11	16828	49	TNIK,CTNND2,FGFR3,RYR3,MACF1,TRPS1,ABLIM1,ATP13A4,NTM,GPM6A,NEBL
8.632e-04	-7.05	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	7	18094	48	RYR3,ITPR2,GPM6A,SLC1A2,SLC4A4,SLC1A3,ATP1A2
8.657e-04	-7.05	asymmetric cell division	biological process	GO:0008356	16	2	18204	50	PARD3,SOX5
9.003e-04	-7.01	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	7	19454	50	FGFR3,AHCYL2,DTNA,ABLIM1,NHSL1,PARD3,TNIK
9.072e-04	-7.01	prostate	COSMIC cancer mutations	prostate	13883	48	16828	49	LSAMP,TNIK,SOX5,NFIA,AQP4,NKAIN3,ATP1A2,ABLIM1,NPAS3,PON2,NTM,PTPRZ1,FGFR3,BMPR1B,SLC1A2,GJA1,CTNND2,ZBTB20,MACF1,PARD3,NEBL,SPON1,DTNA,RYR3,PARD3B,PREX2,SPARCL1,CDH20,AHCYL2,ITPR2,LIFR,TRPS1,SLC1A3,FBXL7,CPE,MSI2,LRIG1,GPM6A,GPC5,RFX4,PITPNC1,NHSL1,SORBS1,SFXN5,ATP13A4,MEIS2,ZNRF3,SLC4A4
9.332e-04	-6.98	bone	COSMIC cancer mutations	bone	8157	35	16828	49	CTNND2,FGFR3,PTPRZ1,MACF1,ZBTB20,SORBS1,SFXN5,ATP13A4,GLUL,PARD3,NEBL,SLC4A4,SPON1,PARD3B,LSAMP,DTNA,RYR3,TNIK,SOX5,SPARCL1,PREX2,LIFR,ITPR2,ATP1A2,AHCYL2,NKAIN3,NPAS3,TRPS1,SLC1A3,CPE,ABLIM1,PON2,LRIG1,GPM6A,GPC5
9.648e-04	-6.94	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	2	19454	50	FGFR3,PARD3
9.763e-04	-6.93	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	5	16828	49	PREX2,FGFR3,SLC1A2,SOX5,RYR3
9.794e-04	-6.93	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	2	18204	50	ATP1A2,GJA1
9.873e-04	-6.92	intracellular chemical homeostasis	biological process	GO:0055082	581	7	18204	50	AQP4,SLC1A3,ATP13A4,RYR3,ATP1A2,ZBTB20,SLC4A4
9.965e-04	-6.91	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	10	18204	50	ABLIM1,PREX2,CTNNA2,PARD3,BMPR1B,RFX4,GPM6A,PTPRZ1,TNIK,CTNND2
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	GPM6A,LSAMP,NTM
1.026e-03	-6.88	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	2	18094	48	RYR3,ITPR2
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A3,SLC1A2
1.030e-03	-6.88	FLOT1 (flotillin 1)	protein interactions	10211	453	6	19454	50	PARD3,SORBS1,SOX5,ABLIM1,MACF1,DTNA
1.048e-03	-6.86	Wnt signaling pathway	biological process	GO:0016055	283	5	18204	50	TNIK,CPE,MACF1,CTNND2,ZNRF3
1.049e-03	-6.86	HNRNPL (heterogeneous nuclear ribonucleoprotein L)	protein interactions	3191	1958	13	19454	50	ABLIM1,BMPR1B,PARD3,TRPS1,PARD3B,AHCYL2,MSI2,NFIA,PON2,ZBTB20,MACF1,FGFR3,DTNA
1.059e-03	-6.85	regulation of cartilage development	biological process	GO:0061035	73	3	18204	50	TRPS1,BMPR1B,SOX5
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP1A2,ATP13A4
1.071e-03	-6.84	astrocyte projection	cellular component	GO:0097449	19	2	19108	49	SLC1A2,AQP4
1.082e-03	-6.83	cell junction assembly	biological process	GO:0034329	285	5	18204	50	GPM6A,SORBS1,GJA1,PARD3,CDH20
1.093e-03	-6.82	Bile secretion	KEGG pathways	hsa04976	71	3	7161	21	ATP1A2,AQP4,SLC4A4
1.093e-03	-6.82	Bile secretion	KEGG pathways	ko04976	71	3	7161	21	SLC4A4,ATP1A2,AQP4
1.109e-03	-6.80	glutamate dependent acid resistance	BIOCYC pathways	HUMAN_PWY0-1305	1	1	902	1	GLUL
1.109e-03	-6.80	L-glutamine biosynthesis I	BIOCYC pathways	META_GLNSYN-PWY	1	1	902	1	GLUL
1.109e-03	-6.80	glutamine biosynthesis	BIOCYC pathways	HUMAN_GLNSYN-PWY	1	1	902	1	GLUL
1.134e-03	-6.78	spleen	COSMIC cancer mutations	spleen	408	6	16828	49	SORBS1,MEIS2,NTM,PARD3B,PTPRZ1,TNIK
1.138e-03	-6.78	Adherens junction	KEGG pathways	hsa04520	72	3	7161	21	SORBS1,PARD3,CTNNA2
1.138e-03	-6.78	Adherens junction	KEGG pathways	ko04520	72	3	7161	21	PARD3,SORBS1,CTNNA2
1.150e-03	-6.77	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	50	ATP13A4,ATP1A2
1.165e-03	-6.76	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	49	16828	49	SLC4A4,ZNRF3,MEIS2,ATP13A4,PITPNC1,NHSL1,SFXN5,SORBS1,RFX4,MSI2,GPC5,GPM6A,LRIG1,SLC1A3,CPE,FBXL7,TRPS1,LIFR,ITPR2,CDH20,AHCYL2,PARD3B,RYR3,DTNA,SPARCL1,PREX2,NEBL,SPON1,GLUL,PARD3,MACF1,ZBTB20,CTNND2,GJA1,SLC1A2,PTPRZ1,BMPR1B,FGFR3,PON2,NTM,NPAS3,ABLIM1,NFIA,ATP1A2,AQP4,NKAIN3,LSAMP,SOX5,TNIK
1.226e-03	-6.70	GSC (goosecoid homeobox)	protein interactions	145258	82	3	19454	50	NFIA,TRPS1,SOX5
1.227e-03	-6.70	cartilage condensation	biological process	GO:0001502	19	2	18204	50	BMPR1B,SOX5
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC1A2,SLC4A4,SLC1A3
1.271e-03	-6.67	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	20	16828	49	PON2,NEBL,SLC4A4,LRIG1,SPON1,GPC5,GPM6A,ABLIM1,PARD3,ZBTB20,NHSL1,MACF1,ATP1A2,RYR3,PREX2,PTPRZ1,TNIK,SOX5,SPARCL1,CTNND2
1.281e-03	-6.66	middle_third	COSMIC cancer mutations	middle_third	3533	20	16828	49	ATP1A2,ZBTB20,NHSL1,MACF1,PREX2,PTPRZ1,TNIK,SOX5,SPARCL1,CTNND2,RYR3,SLC4A4,LRIG1,SPON1,GPC5,GPM6A,PON2,NEBL,ABLIM1,PARD3
1.283e-03	-6.66	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	50	GJA1,SLC1A2,SLC1A3
1.283e-03	-6.66	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	3	18204	50	ZBTB20,SLC4A4,SORBS1
1.290e-03	-6.65	cartilage development	biological process	GO:0051216	173	4	18204	50	NFIA,FGFR3,BMPR1B,SOX5
1.314e-03	-6.63	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	8	16828	49	NEBL,ITPR2,DTNA,SLC1A3,SOX5,PARD3,CTNND2,TRPS1
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	MACF1,SORBS1
1.318e-03	-6.63	HTR2A (5-hydroxytryptamine receptor 2A)	protein interactions	3356	21	2	19454	50	GLUL,PON2
1.321e-03	-6.63	animal organ morphogenesis	biological process	GO:0009887	988	9	18204	50	CTNNA2,GJA1,SOX5,BMPR1B,ABLIM1,LRIG1,MEIS2,FGFR3,CPE
1.357e-03	-6.60	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	14	19108	49	GPM6A,CTNNA2,GLUL,ABLIM1,DTNA,CTNND2,AQP4,PARD3,MACF1,AHCYL2,SLC1A2,ATP1A2,SLC1A3,BMPR1B
1.359e-03	-6.60	cell projection organization	biological process	GO:0030030	1200	10	18204	50	ABLIM1,PREX2,PARD3,CTNNA2,CTNND2,TNIK,PTPRZ1,RFX4,GPM6A,BMPR1B
1.361e-03	-6.60	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	50	SLC1A3,SLC1A2
1.361e-03	-6.60	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	2	18204	50	BMPR1B,SOX5
1.397e-03	-6.57	contractile actin filament bundle	cellular component	GO:0097517	86	3	19108	49	ABLIM1,NEBL,SORBS1
1.397e-03	-6.57	stress fiber	cellular component	GO:0001725	86	3	19108	49	SORBS1,ABLIM1,NEBL
1.398e-03	-6.57	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	32	16828	49	ABLIM1,CPE,FBXL7,SLC1A3,GPC5,GPM6A,LRIG1,PON2,PREX2,SOX5,RYR3,LSAMP,NKAIN3,CDH20,AHCYL2,ATP1A2,ITPR2,LIFR,PARD3,ATP13A4,MEIS2,SPON1,SLC4A4,NEBL,BMPR1B,FGFR3,RFX4,CTNND2,SLC1A2,SFXN5,NHSL1,MACF1
1.439e-03	-6.54	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	22	16828	49	ATP13A4,TRPS1,PARD3,CPE,LRIG1,ZNRF3,GPC5,RYR3,DTNA,LSAMP,FGFR3,PTPRZ1,TNIK,SOX5,CTNND2,SPARCL1,NFIA,MACF1,AQP4,ITPR2,LIFR,ATP1A2
1.484e-03	-6.51	ROR2 (receptor tyrosine kinase like orphan receptor 2)	protein interactions	4920	327	5	19454	50	DTNA,TNIK,GJA1,SORBS1,PARD3
1.502e-03	-6.50	positive regulation of glycolytic process	biological process	GO:0045821	21	2	18204	50	ZBTB20,SLC4A4
1.502e-03	-6.50	positive regulation of nucleotide catabolic process	biological process	GO:0030813	21	2	18204	50	SLC4A4,ZBTB20
1.502e-03	-6.50	positive regulation of purine nucleotide catabolic process	biological process	GO:0033123	21	2	18204	50	SLC4A4,ZBTB20
1.502e-03	-6.50	cell aggregation	biological process	GO:0098743	21	2	18204	50	SOX5,BMPR1B
1.548e-03	-6.47	SFN (stratifin)	protein interactions	2810	671	7	19454	50	SORBS1,PARD3,TNIK,ABLIM1,NFIA,MACF1,PARD3B
1.582e-03	-6.45	TIMM10B (translocase of inner mitochondrial membrane 10B)	protein interactions	26515	23	2	19454	50	MSI2,MEIS2
1.582e-03	-6.45	ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8)	protein interactions	29801	23	2	19454	50	PARD3,GJA1
1.620e-03	-6.43	OCLN (occludin)	protein interactions	100506658	495	6	19454	50	GJA1,TNIK,PARD3,DTNA,ABLIM1,MACF1
1.644e-03	-6.41	chondrocyte differentiation	biological process	GO:0002062	85	3	18204	50	FGFR3,BMPR1B,SOX5
1.649e-03	-6.41	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	50	ATP1A2,SLC1A3
1.649e-03	-6.41	cell communication by electrical coupling	biological process	GO:0010644	22	2	18204	50	ATP1A2,GJA1
1.664e-03	-6.40	monoatomic cation transmembrane transport	biological process	GO:0098655	636	7	18204	50	RYR3,ATP13A4,SLC1A3,ITPR2,GPM6A,SLC4A4,ATP1A2
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A3,SLC1A2
1.695e-03	-6.38	actomyosin	cellular component	GO:0042641	92	3	19108	49	SORBS1,ABLIM1,NEBL
1.708e-03	-6.37	RLN1 (relaxin 1)	protein interactions	6013	92	3	19454	50	PON2,LRIG1,CPE
1.723e-03	-6.36	LNP1 (leukemia NUP98 fusion partner 1)	protein interactions	348801	24	2	19454	50	AHCYL2,GLUL
1.726e-03	-6.36	Cation_ATPase_N	smart domains	SM00831	16	2	9717	38	ATP1A2,ATP13A4
1.751e-03	-6.35	neuron projection	cellular component	GO:0043005	1331	10	19108	49	DTNA,AHCYL2,CTNND2,CTNNA2,GPM6A,SLC1A3,PARD3,BMPR1B,SLC1A2,ATP1A2
1.792e-03	-6.32	gallbladder	COSMIC cancer mutations	gallbladder	2821	17	16828	49	PARD3,TRPS1,SLC4A4,LRIG1,ZNRF3,RYR3,SPARCL1,CTNND2,TNIK,PTPRZ1,PREX2,FGFR3,MACF1,NHSL1,PITPNC1,ITPR2,NKAIN3
1.792e-03	-6.32	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	17	16828	49	TRPS1,PARD3,SLC4A4,ZNRF3,LRIG1,RYR3,TNIK,CTNND2,SPARCL1,PREX2,PTPRZ1,FGFR3,MACF1,PITPNC1,NHSL1,ITPR2,NKAIN3
1.832e-03	-6.30	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	48	ATP1A2,ATP13A4
1.832e-03	-6.30	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	48	ATP13A4,ATP1A2
1.848e-03	-6.29	cell surface	cellular component	GO:0009986	896	8	19108	49	SLC4A4,SLC1A3,GPC5,SLC1A2,AQP4,LIFR,ATP1A2,FGFR3
1.854e-03	-6.29	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	4	19454	50	DTNA,PARD3B,ABLIM1,GJA1
1.888e-03	-6.27	UTRN (utrophin)	protein interactions	7402	205	4	19454	50	DTNA,FGFR3,GJA1,PARD3
1.909e-03	-6.26	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	12	16828	49	PREX2,FGFR3,PTPRZ1,CTNND2,DTNA,PARD3B,CDH20,SORBS1,LIFR,MACF1,ABLIM1,CPE
1.909e-03	-6.26	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	12	16828	49	LIFR,SORBS1,CDH20,MACF1,CTNND2,PREX2,PTPRZ1,FGFR3,PARD3B,DTNA,CPE,ABLIM1
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.913e-03	-6.26	human chr10p11.22-p11.21	chromosome location	human chr10p11.22-p11.21	1	1	26134	50	PARD3
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.915e-03	-6.26	actin filament bundle	cellular component	GO:0032432	96	3	19108	49	SORBS1,ABLIM1,NEBL
1.997e-03	-6.22	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	21	ATP1A2,SLC4A4
1.997e-03	-6.22	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	21	SLC4A4,ATP1A2
2.021e-03	-6.20	skin-face-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-face-malignant_melanoma-lentigo_maligna	23	2	16828	49	PREX2,FGFR3
2.130e-03	-6.15	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	50	SLC1A2,SLC1A3
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	CDH20,DTNA,CTNNA2
2.161e-03	-6.14	cell projection	cellular component	GO:0042995	2398	14	19108	49	AQP4,PARD3,CTNNA2,GPM6A,GLUL,CTNND2,ABLIM1,DTNA,SLC1A2,ATP1A2,SLC1A3,BMPR1B,AHCYL2,MACF1
2.167e-03	-6.13	Salivary secretion	KEGG pathways	ko04970	90	3	7161	21	RYR3,ATP1A2,ITPR2
2.167e-03	-6.13	Salivary secretion	KEGG pathways	hsa04970	90	3	7161	21	ITPR2,ATP1A2,RYR3
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	ABLIM1,DTNA
2.181e-03	-6.13	HPCAL4 (hippocalcin like 4)	protein interactions	51440	27	2	19454	50	GPM6A,AQP4
2.181e-03	-6.13	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	30	SLC1A2,SLC1A3
2.185e-03	-6.13	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	7	19454	50	MSI2,SLC1A3,MACF1,DTNA,PARD3,TNIK,ABLIM1
2.198e-03	-6.12	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	10	16828	49	LSAMP,TNIK,PARD3,SOX5,CTNND2,NKAIN3,AQP4,ITPR2,SPON1,GPC5
2.217e-03	-6.11	L-glutamate and L-glutamine biosynthesis	BIOCYC pathways	META_PWY-5505	2	1	902	1	GLUL
2.226e-03	-6.11	membrane	cellular component	GO:0016020	9220	34	19108	49	ATP1A2,GJA1,PON2,GPC5,ITPR2,MACF1,CPE,AQP4,LIFR,LRIG1,PARD3,ATP13A4,TNIK,LSAMP,FGFR3,CTNNA2,GLUL,SORBS1,SLC1A2,PTPRZ1,SFXN5,SLC1A3,SLC4A4,ZNRF3,BMPR1B,NKAIN3,CDH20,PARD3B,PREX2,NTM,GPM6A,RYR3,DTNA,CTNND2
2.291e-03	-6.08	CAV1 (caveolin 1)	protein interactions	857	719	7	19454	50	PARD3,TNIK,GJA1,MACF1,SLC1A3,DTNA,AHCYL2
2.304e-03	-6.07	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	50	SLC1A3,SLC1A2
2.317e-03	-6.07	protein binding	molecular function	GO:0005515	13983	45	18094	48	CDH20,GJA1,PITPNC1,LRIG1,SFXN5,ITPR2,GPM6A,MACF1,CTNNA2,TNIK,CTNND2,NTM,RYR3,PARD3B,GLUL,ABLIM1,SPON1,LIFR,BMPR1B,ATP1A2,DTNA,AHCYL2,SORBS1,PTPRZ1,PON2,NPAS3,SPARCL1,AQP4,ZNRF3,GPC5,SLC1A3,LSAMP,PARD3,RFX4,CPE,NFIA,FGFR3,NEBL,FBXL7,MSI2,TRPS1,MEIS2,SOX5,SLC1A2,SLC4A4
2.341e-03	-6.06	actin filament binding	molecular function	GO:0051015	211	4	18094	48	CTNNA2,MACF1,ABLIM1,NEBL
2.362e-03	-6.05	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	48	16828	49	GPC5,GPM6A,LRIG1,SLC1A3,FBXL7,CPE,TRPS1,AHCYL2,CDH20,ITPR2,LIFR,RYR3,DTNA,PARD3B,PREX2,SPARCL1,MEIS2,SLC4A4,ZNRF3,ATP13A4,NHSL1,PITPNC1,SFXN5,SORBS1,RFX4,PON2,NTM,ABLIM1,NPAS3,NFIA,AQP4,NKAIN3,ATP1A2,LSAMP,SOX5,TNIK,NEBL,SPON1,GLUL,PARD3,ZBTB20,MACF1,BMPR1B,PTPRZ1,FGFR3,CTNND2,SLC1A2,GJA1
2.377e-03	-6.04	skeletal system development	biological process	GO:0001501	500	6	18204	50	SOX5,BMPR1B,GJA1,TRPS1,FGFR3,NFIA
2.412e-03	-6.03	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	5	16828	49	PARD3B,NTM,PTPRZ1,MEIS2,SORBS1
2.424e-03	-6.02	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	3	19454	50	ABLIM1,SORBS1,SPARCL1
2.496e-03	-5.99	system process	biological process	GO:0003008	2015	13	18204	50	SLC1A3,DTNA,AQP4,ABLIM1,SLC1A2,ATP1A2,LRIG1,MEIS2,CTNNA2,RYR3,GJA1,SLC4A4,PTPRZ1
2.498e-03	-5.99	cellular response to organonitrogen compound	biological process	GO:0071417	505	6	18204	50	RYR3,GJA1,SORBS1,ITPR2,SLC1A3,SLC1A2
2.514e-03	-5.99	INSC (INSC spindle orientation adaptor protein)	protein interactions	387755	29	2	19454	50	PARD3,PARD3B
2.530e-03	-5.98	Pancreatic secretion	KEGG pathways	ko04972	95	3	7161	21	ITPR2,SLC4A4,ATP1A2
2.530e-03	-5.98	Pancreatic secretion	KEGG pathways	hsa04972	95	3	7161	21	SLC4A4,ITPR2,ATP1A2
2.570e-03	-5.96	Sh2b1 (SH2B adaptor protein 1)	protein interactions	20399	1	1	19454	50	FGFR3
2.570e-03	-5.96	fgf3.L (fibroblast growth factor 3 L homeolog)	protein interactions	373669	1	1	19454	50	FGFR3
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.593e-03	-5.95	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	44	ATP1A2,ATP13A4
2.614e-03	-5.95	response to alkaloid	biological process	GO:0043279	100	3	18204	50	SLC1A2,SLC1A3,RYR3
2.615e-03	-5.95	cellular homeostasis	biological process	GO:0019725	689	7	18204	50	ATP13A4,SLC1A3,AQP4,ATP1A2,RYR3,SLC4A4,ZBTB20
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A2,SLC1A3
2.673e-03	-5.92	ligand-gated calcium channel activity	molecular function	GO:0099604	29	2	18094	48	RYR3,ITPR2
2.681e-03	-5.92	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	5	16828	49	PARD3B,NTM,SORBS1,PTPRZ1,MEIS2
2.698e-03	-5.92	EN1 (engrailed homeobox 1)	protein interactions	2019	108	3	19454	50	AHCYL2,NFIA,TRPS1
2.700e-03	-5.91	Gln_synth_N_conserv_site	interpro domains	IPR027302	1	1	18521	50	GLUL
2.700e-03	-5.91	ZNRF3_Znf_RING	interpro domains	IPR045903	1	1	18521	50	ZNRF3
2.700e-03	-5.91	M14_CPE_CPD	interpro domains	IPR034232	1	1	18521	50	CPE
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	Alpha_helix_dom_sf	interpro domains	IPR035091	1	1	18521	50	GJA1
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	LIFR_N	interpro domains	IPR040901	1	1	18521	50	LIFR
2.700e-03	-5.91	Gln_synth_gly_rich_site	interpro domains	IPR027303	1	1	18521	50	GLUL
2.700e-03	-5.91	TRPS1	interpro domains	IPR028440	1	1	18521	50	TRPS1
2.700e-03	-5.91	Connexin43	interpro domains	IPR002261	1	1	18521	50	GJA1
2.700e-03	-5.91	Connexin43_C	interpro domains	IPR013124	1	1	18521	50	GJA1
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	CTNND2,SLC1A2,GJA1,FGFR3,BMPR1B,PTPRZ1,MACF1,ZBTB20,PARD3,GLUL,SPON1,NEBL,SOX5,TNIK,LSAMP,ATP1A2,AQP4,NKAIN3,NFIA,NPAS3,ABLIM1,NTM,PON2,RFX4,SFXN5,SORBS1,PITPNC1,NHSL1,ATP13A4,ZNRF3,SLC4A4,MEIS2,SPARCL1,PREX2,PARD3B,RYR3,DTNA,LIFR,ITPR2,AHCYL2,CDH20,FBXL7,SLC1A3,CPE,TRPS1,GPC5,GPM6A,LRIG1
2.747e-03	-5.90	atrial ventricular junction remodeling	biological process	GO:0003294	1	1	18204	50	GJA1
2.747e-03	-5.90	olfactory cortex development	biological process	GO:0021989	1	1	18204	50	ATP1A2
2.747e-03	-5.90	milk ejection reflex	biological process	GO:0060156	1	1	18204	50	GJA1
2.747e-03	-5.90	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	50	ATP1A2
2.749e-03	-5.90	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	30	RYR3,ATP1A2,ITPR2,SORBS1
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	SPARCL1,PREX2,PARD3B,RYR3,DTNA,LIFR,ITPR2,CDH20,AHCYL2,TRPS1,SLC1A3,FBXL7,CPE,LRIG1,GPM6A,GPC5,RFX4,SORBS1,SFXN5,NHSL1,PITPNC1,ATP13A4,SLC4A4,ZNRF3,MEIS2,TNIK,SOX5,LSAMP,ATP1A2,AQP4,NKAIN3,NFIA,NPAS3,ABLIM1,NTM,PON2,GJA1,SLC1A2,CTNND2,FGFR3,PTPRZ1,BMPR1B,MACF1,ZBTB20,PARD3,GLUL,SPON1,NEBL
2.810e-03	-5.87	Gln-synt_N	pfam domains	PF03951	1	1	17795	50	GLUL
2.810e-03	-5.87	FGFR3_TM	pfam domains	PF21165	1	1	17795	50	FGFR3
2.810e-03	-5.87	Connexin43	pfam domains	PF03508	1	1	17795	50	GJA1
2.810e-03	-5.87	LIFR_N	pfam domains	PF18207	1	1	17795	50	LIFR
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CTNNA2,CDH20
2.863e-03	-5.86	DST (dystonin)	protein interactions	667	230	4	19454	50	PARD3,GJA1,TNIK,ATP1A2
2.917e-03	-5.84	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	REACTOME pathways	R-HSA-190840	1	1	10285	30	GJA1
2.917e-03	-5.84	t(4;14) translocations of FGFR3	REACTOME pathways	R-HSA-2033515	1	1	10285	30	FGFR3
2.978e-03	-5.82	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	6	19454	50	AHCYL2,DTNA,SLC1A3,MACF1,GJA1,PARD3
2.991e-03	-5.81	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	3	19454	50	TRPS1,NFIA,SOX5
2.993e-03	-5.81	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	8	19454	50	PARD3,NHSL1,SORBS1,PITPNC1,ABLIM1,PARD3B,MACF1,FGFR3
3.041e-03	-5.80	-	gene3d domains	6.10.250.1740	1	1	14470	44	FGFR3
3.041e-03	-5.80	Connexin43	gene3d domains	1.20.5.1130	1	1	14470	44	GJA1
3.051e-03	-5.79	intracellularly ligand-gated monoatomic ion channel activity	molecular function	GO:0005217	31	2	18094	48	ITPR2,RYR3
3.062e-03	-5.79	L-glutamate import	biological process	GO:0051938	30	2	18204	50	SLC1A2,SLC1A3
3.093e-03	-5.78	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	4	19454	50	MACF1,DTNA,PARD3,GJA1
3.222e-03	-5.74	SMAD7 (SMAD family member 7)	protein interactions	4092	115	3	19454	50	PARD3,SOX5,BMPR1B
3.289e-03	-5.72	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	22	16828	49	PARD3,GLUL,MEIS2,ZNRF3,SPON1,RFX4,FGFR3,PTPRZ1,CTNND2,NHSL1,MACF1,ABLIM1,TRPS1,SLC1A3,GPM6A,PON2,PREX2,SOX5,RYR3,DTNA,LIFR,ATP1A2
3.289e-03	-5.72	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	22	16828	49	GPM6A,SPON1,ZNRF3,MEIS2,PON2,PARD3,SLC1A3,TRPS1,ABLIM1,GLUL,ATP1A2,LIFR,MACF1,NHSL1,SOX5,CTNND2,PTPRZ1,FGFR3,PREX2,RFX4,DTNA,RYR3
3.302e-03	-5.71	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	3	19454	50	GLUL,SPARCL1,MACF1
3.326e-03	-5.71	GABA shunt	BIOCYC pathways	HUMAN_GLUDEG-I-PWY	3	1	902	1	GLUL
3.336e-03	-5.70	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	6	19454	50	TNIK,ITPR2,GJA1,PARD3,DTNA,MACF1
3.383e-03	-5.69	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	21	16828	49	MACF1,AHCYL2,CDH20,ITPR2,ATP1A2,PARD3B,RFX4,FGFR3,PREX2,SLC1A2,CTNND2,PON2,NEBL,MEIS2,SLC4A4,LRIG1,GPC5,ATP13A4,ABLIM1,TRPS1,PARD3
3.415e-03	-5.68	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	50	ATP1A2,ATP13A4
3.430e-03	-5.68	lentigo_maligna	COSMIC cancer mutations	lentigo_maligna	30	2	16828	49	PREX2,FGFR3
3.430e-03	-5.68	skin-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-malignant_melanoma-acral_lentiginous	30	2	16828	49	FGFR3,PREX2
3.479e-03	-5.66	positive regulation of ATP metabolic process	biological process	GO:1903580	32	2	18204	50	SLC4A4,ZBTB20
3.479e-03	-5.66	microtubule organizing center localization	biological process	GO:0061842	32	2	18204	50	PARD3B,PARD3
3.479e-03	-5.66	transepithelial transport	biological process	GO:0070633	32	2	18204	50	SLC1A3,SLC1A2
3.479e-03	-5.66	centrosome localization	biological process	GO:0051642	32	2	18204	50	PARD3,PARD3B
3.479e-03	-5.66	positive regulation of cartilage development	biological process	GO:0061036	32	2	18204	50	SOX5,BMPR1B
3.482e-03	-5.66	cell adhesion molecule binding	molecular function	GO:0050839	560	6	18094	48	PTPRZ1,CPE,CTNNA2,MACF1,CTNND2,CDH20
3.611e-03	-5.62	GLNA_ATP	prosite domains	PS00181	1	1	12186	44	GLUL
3.611e-03	-5.62	GLNA_1	prosite domains	PS00180	1	1	12186	44	GLUL
3.637e-03	-5.62	Cation_ATPase	pfam domains	PF13246	32	2	17795	50	ATP13A4,ATP1A2
3.649e-03	-5.61	TPRA1 (transmembrane protein adipocyte associated 1)	protein interactions	131601	35	2	19454	50	BMPR1B,ITPR2
3.688e-03	-5.60	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	3	18094	48	SLC1A2,SLC4A4,SLC1A3
3.688e-03	-5.60	calcium channel activity	molecular function	GO:0005262	117	3	18094	48	ITPR2,RYR3,GPM6A
3.692e-03	-5.60	dendrite development	biological process	GO:0016358	113	3	18204	50	CTNND2,CTNNA2,PREX2
3.697e-03	-5.60	response to auditory stimulus	biological process	GO:0010996	33	2	18204	50	SLC1A3,ATP1A2
3.741e-03	-5.59	connective tissue development	biological process	GO:0061448	232	4	18204	50	BMPR1B,SOX5,FGFR3,NFIA
3.827e-03	-5.57	eye development	biological process	GO:0001654	381	5	18204	50	NFIA,MEIS2,GJA1,BMPR1B,GPM6A
3.836e-03	-5.56	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	8	19454	50	MACF1,SLC1A3,DTNA,AHCYL2,PREX2,PON2,PARD3,GJA1
3.857e-03	-5.56	ZNRF1 (zinc and ring finger 1)	protein interactions	84937	36	2	19454	50	ATP1A2,GLUL
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A3,SLC1A2
3.908e-03	-5.54	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	8	16828	49	LRIG1,ITPR2,ATP1A2,ABLIM1,PTPRZ1,FGFR3,NPAS3,SPARCL1
3.911e-03	-5.54	DELLA	smart domains	SM01129	1	1	9717	38	MACF1
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	FGFR3,LSAMP,LRIG1,NTM
3.936e-03	-5.54	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	21	16828	49	SLC1A3,PARD3,TRPS1,NPAS3,PON2,SPON1,ZNRF3,RYR3,PARD3B,PTPRZ1,FGFR3,PREX2,SPARCL1,CTNND2,GJA1,NHSL1,NFIA,MACF1,AQP4,CDH20,SORBS1
3.969e-03	-5.53	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	4	19454	50	TNIK,GJA1,SORBS1,NHSL1
4.001e-03	-5.52	visual system development	biological process	GO:0150063	385	5	18204	50	BMPR1B,GPM6A,GJA1,MEIS2,NFIA
4.005e-03	-5.52	mucosal	COSMIC cancer mutations	mucosal	2009	13	16828	49	ATP1A2,LIFR,SORBS1,CTNND2,SPARCL1,BMPR1B,PREX2,FGFR3,NEBL,CPE,PARD3,ABLIM1,ATP13A4
4.005e-03	-5.52	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	13	16828	49	PREX2,BMPR1B,FGFR3,SPARCL1,CTNND2,SORBS1,LIFR,ATP1A2,ATP13A4,ABLIM1,CPE,PARD3,NEBL
4.018e-03	-5.52	AQUAPORIN4	prints domains	PR02016	1	1	5227	21	AQP4
4.018e-03	-5.52	CONNEXINA1	prints domains	PR01132	1	1	5227	21	GJA1
4.071e-03	-5.50	ROBO2 (roundabout guidance receptor 2)	protein interactions	6092	37	2	19454	50	GJA1,CPE
4.096e-03	-5.50	muscle contraction	biological process	GO:0006936	238	4	18204	50	DTNA,RYR3,ATP1A2,GJA1
4.152e-03	-5.48	plasma membrane protein complex	cellular component	GO:0098797	600	6	19108	49	GJA1,CTNNA2,ATP1A2,BMPR1B,SORBS1,CDH20
4.238e-03	-5.46	extraskeletal	COSMIC cancer mutations	extraskeletal	903	8	16828	49	ATP1A2,LRIG1,ITPR2,ABLIM1,FGFR3,PTPRZ1,SPARCL1,NPAS3
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP13A4,ATP1A2
4.271e-03	-5.46	sensory system development	biological process	GO:0048880	391	5	18204	50	GJA1,BMPR1B,GPM6A,MEIS2,NFIA
4.289e-03	-5.45	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	49	ATP13A4,PREX2,FGFR3,CTNND2,MACF1,SORBS1,NTM,SLC4A4,LIFR
4.310e-03	-5.45	membrane protein complex	cellular component	GO:0098796	1261	9	19108	49	SLC1A2,ATP1A2,GJA1,SLC1A3,BMPR1B,CTNNA2,RYR3,CDH20,SORBS1
4.373e-03	-5.43	MARK2 (microtubule affinity regulating kinase 2)	protein interactions	2011	259	4	19454	50	PARD3,GJA1,PARD3B,DTNA
4.413e-03	-5.42	arm	COSMIC cancer mutations	arm	1331	10	16828	49	ATP1A2,SLC4A4,NTM,SORBS1,MACF1,ZBTB20,TRPS1,NPAS3,FGFR3,PARD3B
4.448e-03	-5.42	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	3	19454	50	ITPR2,ABLIM1,ZBTB20
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP13A4,ATP1A2
4.545e-03	-5.39	DVL1 (dishevelled segment polarity protein 1)	protein interactions	1855	130	3	19454	50	ZNRF3,GJA1,PARD3
4.603e-03	-5.38	organic anion transport	biological process	GO:0015711	398	5	18204	50	SLC1A2,SLC4A4,GJA1,SLC1A3,SFXN5
4.610e-03	-5.38	tight junction	cellular component	GO:0070160	131	3	19108	49	GJA1,PARD3,PARD3B
4.616e-03	-5.38	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	28	16828	49	CTNND2,RFX4,FGFR3,PTPRZ1,BMPR1B,MACF1,ZBTB20,PITPNC1,PARD3,ATP13A4,GLUL,ZNRF3,SLC4A4,SPON1,TNIK,SOX5,PREX2,RYR3,LIFR,ITPR2,ATP1A2,NFIA,CPE,ABLIM1,LRIG1,NTM,GPC5,PON2
4.616e-03	-5.38	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	28	16828	49	ZNRF3,SLC4A4,SPON1,ATP13A4,GLUL,PARD3,MACF1,ZBTB20,PITPNC1,CTNND2,RFX4,FGFR3,PTPRZ1,BMPR1B,PON2,NTM,LRIG1,GPC5,CPE,ABLIM1,NFIA,LIFR,ITPR2,ATP1A2,RYR3,TNIK,SOX5,PREX2
4.631e-03	-5.38	positive regulation of nucleotide metabolic process	biological process	GO:0045981	37	2	18204	50	SLC4A4,ZBTB20
4.631e-03	-5.38	positive regulation of purine nucleotide metabolic process	biological process	GO:1900544	37	2	18204	50	SLC4A4,ZBTB20
4.631e-03	-5.38	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	50	SORBS1,SLC1A2
4.632e-03	-5.37	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	44	16828	49	RYR3,PARD3B,PREX2,SPARCL1,AHCYL2,CDH20,ITPR2,LIFR,TRPS1,CPE,FBXL7,SLC1A3,LRIG1,GPC5,GPM6A,RFX4,NHSL1,PITPNC1,SORBS1,SFXN5,ATP13A4,MEIS2,LSAMP,TNIK,SOX5,NFIA,AQP4,NKAIN3,ATP1A2,ABLIM1,NPAS3,PON2,NTM,BMPR1B,FGFR3,PTPRZ1,SLC1A2,GJA1,CTNND2,ZBTB20,MACF1,PARD3,NEBL,SPON1
4.691e-03	-5.36	monoatomic cation transport	biological process	GO:0006812	766	7	18204	50	ITPR2,ATP13A4,RYR3,SLC1A3,ATP1A2,GPM6A,SLC4A4
4.744e-03	-5.35	DZIP1 (DAZ interacting zinc finger protein 1)	protein interactions	22873	40	2	19454	50	PARD3,GJA1
4.873e-03	-5.32	PDZ	pfam domains	PF00595	122	3	17795	50	PARD3B,PREX2,PARD3
4.880e-03	-5.32	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	50	SLC1A3,SLC1A2
4.928e-03	-5.31	cellular response to nitrogen compound	biological process	GO:1901699	580	6	18204	50	GJA1,SLC1A2,SORBS1,SLC1A3,RYR3,ITPR2
4.945e-03	-5.31	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	3	19454	50	CPE,NTM,GPM6A
4.969e-03	-5.30	sensory organ development	biological process	GO:0007423	581	6	18204	50	GJA1,BMPR1B,GPM6A,LRIG1,MEIS2,NFIA
4.977e-03	-5.30	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	21	16828	49	NFIA,NHSL1,MACF1,CDH20,SORBS1,AQP4,RYR3,PARD3B,FGFR3,PTPRZ1,PREX2,GJA1,SPARCL1,CTNND2,PON2,ZNRF3,SPON1,NPAS3,TRPS1,SLC1A3,PARD3
4.980e-03	-5.30	TAFA2 (TAFA chemokine like family member 2)	protein interactions	338811	41	2	19454	50	CPE,LIFR
5.049e-03	-5.29	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	3	19454	50	PARD3,ABLIM1,DTNA
5.049e-03	-5.29	Myo1c (myosin IC)	protein interactions	17913	135	3	19454	50	TRPS1,ITPR2,ABLIM1
5.118e-03	-5.28	cell-cell junction assembly	biological process	GO:0007043	127	3	18204	50	PARD3,CDH20,GJA1
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	DTNA,MACF1,RYR3,SPARCL1
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	THSD1 (thrombospondin type 1 domain containing 1)	protein interactions	55901	2	1	19454	50	GJA1
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	DEFB126 (defensin beta 126)	protein interactions	81623	2	1	19454	50	GJA1
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	50	SLC1A3,ATP1A2
5.154e-03	-5.27	spindle	COSMIC cancer mutations	spindle	386	5	16828	49	FGFR3,PREX2,CPE,CTNND2,MACF1
5.198e-03	-5.26	RDX (radixin)	protein interactions	5962	272	4	19454	50	MACF1,FGFR3,ABLIM1,NEBL
5.251e-03	-5.25	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	3	16828	49	DTNA,FGFR3,CDH20
5.299e-03	-5.24	leukemia inhibitory factor receptor activity	molecular function	GO:0004923	2	1	18094	48	LIFR
5.299e-03	-5.24	glutamine synthetase activity	molecular function	GO:0004356	2	1	18094	48	GLUL
5.299e-03	-5.24	ammonia ligase activity	molecular function	GO:0016211	2	1	18094	48	GLUL
5.302e-03	-5.24	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	6	16828	49	LIFR,SLC4A4,TRPS1,CTNND2,FBXL7,RYR3
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	44	ATP1A2,ATP13A4
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	44	ATP13A4,ATP1A2
5.366e-03	-5.23	NFIB (nuclear factor I B)	protein interactions	4781	138	3	19454	50	SOX5,TRPS1,NFIA
5.379e-03	-5.23	central nervous system development	biological process	GO:0007417	995	8	18204	50	SLC1A2,ATP1A2,MEIS2,PTPRZ1,RFX4,BMPR1B,MSI2,CTNNA2
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.392e-03	-5.22	LIFR_D2	interpro domains	IPR040817	2	1	18521	50	LIFR
5.392e-03	-5.22	Spondin_N_sf	interpro domains	IPR038678	2	1	18521	50	SPON1
5.392e-03	-5.22	Paraoxonase2	interpro domains	IPR008364	2	1	18521	50	PON2
5.392e-03	-5.22	Gln_synth_cat_dom	interpro domains	IPR008146	2	1	18521	50	GLUL
5.392e-03	-5.22	LIF-R-like_Ig-like	interpro domains	IPR048497	2	1	18521	50	LIFR
5.392e-03	-5.22	Spondin_N	interpro domains	IPR009465	2	1	18521	50	SPON1
5.392e-03	-5.22	ZNRF-3_ecto	interpro domains	IPR040700	2	1	18521	50	ZNRF3
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Gln_synt_N	interpro domains	IPR008147	2	1	18521	50	GLUL
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Gln_synt_N_sf	interpro domains	IPR036651	2	1	18521	50	GLUL
5.394e-03	-5.22	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	6	16828	49	RYR3,SLC4A4,TRPS1,LIFR,CTNND2,FBXL7
5.440e-03	-5.21	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	2	19108	49	ITPR2,RYR3
5.486e-03	-5.21	fibroblast growth factor receptor apoptotic signaling pathway	biological process	GO:1902178	2	1	18204	50	FGFR3
5.486e-03	-5.21	Wnt receptor catabolic process	biological process	GO:0038018	2	1	18204	50	ZNRF3
5.486e-03	-5.21	glutamine biosynthetic process	biological process	GO:0006542	2	1	18204	50	GLUL
5.505e-03	-5.20	acral_lentiginous	COSMIC cancer mutations	acral_lentiginous	745	7	16828	49	ATP13A4,MACF1,PREX2,FGFR3,CDH20,PARD3,GJA1
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A3,SLC1A2
5.585e-03	-5.19	CEP89 (centrosomal protein 89)	protein interactions	84902	140	3	19454	50	GJA1,PARD3,ABLIM1
5.611e-03	-5.18	TJP2 (tight junction protein 2)	protein interactions	9414	278	4	19454	50	GJA1,NEBL,PARD3,SORBS1
5.612e-03	-5.18	LIF-R_Ig-like	pfam domains	PF21177	2	1	17795	50	LIFR
5.612e-03	-5.18	ZNRF_3_ecto	pfam domains	PF18212	2	1	17795	50	ZNRF3
5.612e-03	-5.18	Spond_N	pfam domains	PF06468	2	1	17795	50	SPON1
5.612e-03	-5.18	Gln-synt_C	pfam domains	PF00120	2	1	17795	50	GLUL
5.612e-03	-5.18	Reeler	pfam domains	PF02014	2	1	17795	50	SPON1
5.612e-03	-5.18	LIFR_D2	pfam domains	PF17971	2	1	17795	50	LIFR
5.612e-03	-5.18	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	48	GPM6A,RYR3,ITPR2
5.692e-03	-5.17	actin binding	molecular function	GO:0003779	434	5	18094	48	SORBS1,ABLIM1,NEBL,MACF1,CTNNA2
5.696e-03	-5.17	MAB21L2 (mab-21 like 2)	protein interactions	10586	141	3	19454	50	LIFR,MEIS2,CTNNA2
5.817e-03	-5.15	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	50	ITPR2,RYR3,ATP1A2
5.826e-03	-5.15	Transport of connexons to the plasma membrane	REACTOME pathways	R-HSA-190872	2	1	10285	30	GJA1
5.922e-03	-5.13	SLC6A15 (solute carrier family 6 member 15)	protein interactions	55117	143	3	19454	50	PARD3,SFXN5,GJA1
5.939e-03	-5.13	establishment of cell polarity	biological process	GO:0030010	134	3	18204	50	PARD3,PARD3B,GJA1
5.968e-03	-5.12	small_intestine	COSMIC cancer mutations	small_intestine	250	4	16828	49	MACF1,ZNRF3,TNIK,FGFR3
6.037e-03	-5.11	Calml3 (calmodulin-like 3)	protein interactions	70405	144	3	19454	50	MACF1,ABLIM1,ZBTB20
6.073e-03	-5.10	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	44	CTNNA2
6.073e-03	-5.10	Glutamine synthetase, N-terminal domain	gene3d domains	3.10.20.70	2	1	14470	44	GLUL
6.073e-03	-5.10	F-spondin domain	gene3d domains	2.60.40.2130	2	1	14470	44	SPON1
6.073e-03	-5.10	-	gene3d domains	6.20.350.10	2	1	14470	44	RYR3
6.087e-03	-5.10	phosphatidylinositol binding	molecular function	GO:0035091	276	4	18094	48	PITPNC1,PARD3B,PARD3,ITPR2
6.161e-03	-5.09	cell development	biological process	GO:0048468	2236	13	18204	50	PREX2,SLC1A3,MSI2,GPM6A,GJA1,NTM,CTNND2,BMPR1B,PTPRZ1,TNIK,NEBL,PARD3,CTNNA2
6.237e-03	-5.08	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	5	18204	50	SLC1A3,ATP13A4,RYR3,SLC4A4,ATP1A2
6.257e-03	-5.07	active transmembrane transporter activity	molecular function	GO:0022804	444	5	18094	48	SLC1A2,ATP13A4,ATP1A2,SLC1A3,SLC4A4
6.348e-03	-5.06	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	4	19454	50	NEBL,NHSL1,PARD3,SORBS1
6.435e-03	-5.05	cytoskeleton organization	biological process	GO:0007010	1251	9	18204	50	MACF1,GJA1,NEBL,TNIK,SORBS1,PARD3,PARD3B,CTNNA2,ABLIM1
6.441e-03	-5.05	membrane raft	cellular component	GO:0045121	290	4	19108	49	GJA1,ATP1A2,SLC1A2,SORBS1
6.441e-03	-5.04	regulation of generation of precursor metabolites and energy	biological process	GO:0043467	138	3	18204	50	SORBS1,ZBTB20,SLC4A4
6.498e-03	-5.04	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	50	SORBS1,SLC1A2
6.500e-03	-5.04	CNTN1 (contactin 1)	protein interactions	1272	47	2	19454	50	PTPRZ1,GPM6A
6.500e-03	-5.04	LRIG3 (leucine rich repeats and immunoglobulin like domains 3)	protein interactions	121227	47	2	19454	50	GJA1,LRIG1
6.597e-03	-5.02	membrane microdomain	cellular component	GO:0098857	292	4	19108	49	SORBS1,ATP1A2,GJA1,SLC1A2
6.599e-03	-5.02	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	9	19454	50	SOX5,MACF1,MEIS2,ITPR2,MSI2,NFIA,GJA1,TRPS1,LSAMP
6.634e-03	-5.02	GSE1 (Gse1 coiled-coil protein)	protein interactions	23199	149	3	19454	50	SOX5,TNIK,NFIA
6.634e-03	-5.02	vascular process in circulatory system	biological process	GO:0003018	273	4	18204	50	SLC4A4,SLC1A2,ATP1A2,SLC1A3
6.646e-03	-5.01	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	15	16828	49	CDH20,ATP1A2,LIFR,PTPRZ1,PREX2,SOX5,CTNND2,LSAMP,RYR3,MEIS2,NEBL,PARD3,SLC1A3,TRPS1,ATP13A4
6.676e-03	-5.01	inorganic cation transmembrane transport	biological process	GO:0098662	618	6	18204	50	GPM6A,SLC4A4,ATP1A2,RYR3,SLC1A3,ITPR2
6.702e-03	-5.01	neurotransmitter transport	biological process	GO:0006836	140	3	18204	50	SLC1A3,SLC1A2,ATP1A2
6.709e-03	-5.00	apical junction complex	cellular component	GO:0043296	150	3	19108	49	SORBS1,PARD3,PARD3B
6.728e-03	-5.00	behavior	biological process	GO:0007610	619	6	18204	50	PREX2,SLC1A3,MEIS2,ATP1A2,PTPRZ1,SLC1A2
6.788e-03	-4.99	cell communication involved in cardiac conduction	biological process	GO:0086065	45	2	18204	50	ATP1A2,GJA1
6.798e-03	-4.99	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	5	18204	50	ATP1A2,SLC4A4,SLC1A3,RYR3,ATP13A4
6.881e-03	-4.98	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	3	19454	50	TNIK,GJA1,MACF1
6.932e-03	-4.97	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	15	16828	49	NPAS3,ZNRF3,SPON1,PON2,PTPRZ1,FGFR3,PREX2,SPARCL1,CTNND2,RYR3,PARD3B,SORBS1,AQP4,NFIA,MACF1
6.932e-03	-4.97	embryonal	COSMIC cancer mutations	embryonal	2659	15	16828	49	MACF1,NFIA,PON2,SPON1,ZNRF3,AQP4,SORBS1,PARD3B,RYR3,CTNND2,SPARCL1,NPAS3,PTPRZ1,PREX2,FGFR3
6.939e-03	-4.97	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	8	16828	49	CTNND2,PARD3,SOX5,LSAMP,NKAIN3,GPC5,SPON1,ITPR2
6.969e-03	-4.97	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	50	SORBS1,ZBTB20,SLC4A4
6.969e-03	-4.97	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	50	SLC1A3,SLC1A2,SLC4A4
7.064e-03	-4.95	TJP1 (tight junction protein 1)	protein interactions	7082	297	4	19454	50	GJA1,NEBL,PARD3,DTNA
7.084e-03	-4.95	regulation of myelination	biological process	GO:0031641	46	2	18204	50	PTPRZ1,PARD3
7.087e-03	-4.95	symporter activity	molecular function	GO:0015293	148	3	18094	48	SLC1A2,SLC1A3,SLC4A4
7.135e-03	-4.94	SOX6 (SRY-box transcription factor 6)	protein interactions	55553	153	3	19454	50	SOX5,NFIA,TRPS1
7.175e-03	-4.94	PDZ	interpro domains	IPR001478	146	3	18521	50	PREX2,PARD3B,PARD3
7.209e-03	-4.93	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	44	SPARCL1
7.209e-03	-4.93	SPONDIN	prosite domains	PS51020	2	1	12186	44	SPON1
7.209e-03	-4.93	GS_CATALYTIC	prosite domains	PS51987	2	1	12186	44	GLUL
7.209e-03	-4.93	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	44	SPARCL1
7.209e-03	-4.93	GS_BETA_GRASP	prosite domains	PS51986	2	1	12186	44	GLUL
7.266e-03	-4.92	soft_tissue-striated_muscle-rhabdomyosarcoma	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma	594	6	16828	49	TRPS1,GJA1,CTNND2,PREX2,SPON1,MACF1
7.312e-03	-4.92	metal ion transport	biological process	GO:0030001	630	6	18204	50	GPM6A,SLC4A4,ATP1A2,RYR3,SLC1A3,ITPR2
7.368e-03	-4.91	Signaling pathways regulating pluripotency of stem cells	KEGG pathways	ko04550	139	3	7161	21	FGFR3,BMPR1B,LIFR
7.368e-03	-4.91	Signaling pathways regulating pluripotency of stem cells	KEGG pathways	hsa04550	139	3	7161	21	LIFR,FGFR3,BMPR1B
7.404e-03	-4.91	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	4	16828	49	RYR3,LIFR,SOX5,CDH20
7.426e-03	-4.90	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	44	ATP1A2,ATP13A4
7.521e-03	-4.89	adult behavior	biological process	GO:0030534	146	3	18204	50	SLC1A2,ATP1A2,PREX2
7.581e-03	-4.88	intercalated disc	cellular component	GO:0014704	51	2	19108	49	GJA1,ATP1A2
7.587e-03	-4.88	PDZ_sf	interpro domains	IPR036034	149	3	18521	50	PREX2,PARD3B,PARD3
7.592e-03	-4.88	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	49	ZNRF3,MACF1
7.592e-03	-4.88	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	49	ZNRF3,MACF1
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	NHSL1,MACF1
7.617e-03	-4.88	FAM171B (family with sequence similarity 171 member B)	protein interactions	165215	51	2	19454	50	PARD3,GJA1
7.617e-03	-4.88	LINGO1 (leucine rich repeat and Ig domain containing 1)	protein interactions	84894	51	2	19454	50	NTM,PON2
7.631e-03	-4.88	human chr8q23.3	chromosome location	human chr8q23.3	4	1	26134	50	TRPS1
7.647e-03	-4.87	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	10	16828	49	RFX4,PREX2,FGFR3,PTPRZ1,CTNND2,RYR3,CDH20,LIFR,MACF1,NEBL
7.647e-03	-4.87	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	10	16828	49	LIFR,CDH20,NEBL,MACF1,CTNND2,FGFR3,PTPRZ1,PREX2,RFX4,RYR3
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	DEFB124 (defensin beta 124)	protein interactions	245937	3	1	19454	50	GJA1
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	PIGL (phosphatidylinositol glycan anchor biosynthesis class L)	protein interactions	9487	3	1	19454	50	MEIS2
7.700e-03	-4.87	astrocytoma_Grade_I	COSMIC cancer mutations	astrocytoma_Grade_I	139	3	16828	49	FGFR3,PARD3,GPC5
7.702e-03	-4.87	animal organ development	biological process	GO:0048513	2846	15	18204	50	CTNNA2,NEBL,RFX4,BMPR1B,SOX5,NFIA,ABLIM1,CPE,SLC1A2,LRIG1,MEIS2,GJA1,GPM6A,FGFR3,ATP1A2
7.806e-03	-4.85	Gln-synt_C	smart domains	SM01230	2	1	9717	38	GLUL
7.938e-03	-4.84	adenosylhomocysteinase activity	molecular function	GO:0004013	3	1	18094	48	AHCYL2
7.938e-03	-4.84	acid-ammonia (or amide) ligase activity	molecular function	GO:0016880	3	1	18094	48	GLUL
7.938e-03	-4.84	acyl-L-homoserine-lactone lactonohydrolase activity	molecular function	GO:0102007	3	1	18094	48	PON2
7.938e-03	-4.84	hydrolase activity, acting on carbon-sulfur bonds	molecular function	GO:0046508	3	1	18094	48	AHCYL2
7.938e-03	-4.84	inositol 1,4,5-trisphosphate-gated calcium channel activity	molecular function	GO:0005220	3	1	18094	48	ITPR2
7.938e-03	-4.84	lactonohydrolase activity	molecular function	GO:0046573	3	1	18094	48	PON2
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.938e-03	-4.84	oncostatin-M receptor activity	molecular function	GO:0004924	3	1	18094	48	LIFR
7.964e-03	-4.83	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	30	RYR3,ATP1A2,ITPR2
8.007e-03	-4.83	visual learning	biological process	GO:0008542	49	2	18204	50	ATP1A2,MEIS2
8.020e-03	-4.83	PARAOXONASE2	prints domains	PR01787	2	1	5227	21	PON2
8.021e-03	-4.83	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	8	19454	50	NHSL1,PARD3,SORBS1,GJA1,PITPNC1,ABLIM1,PARD3B,MACF1
8.065e-03	-4.82	PTPN14 (protein tyrosine phosphatase non-receptor type 14)	protein interactions	5784	160	3	19454	50	GJA1,CTNNA2,PARD3
8.065e-03	-4.82	SOX5 (SRY-box transcription factor 5)	protein interactions	6660	160	3	19454	50	TRPS1,NFIA,SOX5
8.078e-03	-4.82	Arylesterase	interpro domains	IPR002640	3	1	18521	50	PON2
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	Adenosylhomocysteinase-like	interpro domains	IPR000043	3	1	18521	50	AHCYL2
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	Connexin_C	interpro domains	IPR034634	3	1	18521	50	GJA1
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	Adenosylhomocyst_ase-like_sf	interpro domains	IPR042172	3	1	18521	50	AHCYL2
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	InsP3_rcpt	interpro domains	IPR000493	3	1	18521	50	ITPR2
8.078e-03	-4.82	Reeler_sf	interpro domains	IPR042307	3	1	18521	50	SPON1
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	Ado_hCys_hydrolase_NAD-bd	interpro domains	IPR015878	3	1	18521	50	AHCYL2
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	S-Ado-L-homoCys_hydrolase_CS	interpro domains	IPR020082	3	1	18521	50	AHCYL2
8.078e-03	-4.82	Reeler_dom	interpro domains	IPR002861	3	1	18521	50	SPON1
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	MACF1,DTNA,PARD3,SORBS1
8.124e-03	-4.81	neuronal cell body	cellular component	GO:0043025	489	5	19108	49	BMPR1B,CTNND2,SLC1A3,GPM6A,ATP1A2
8.183e-03	-4.81	Spinal Cord Injury	WikiPathways	WP2431	119	3	5310	19	AQP4,GJA1,PTPRZ1
8.206e-03	-4.80	FOXF2 (forkhead box F2)	protein interactions	2295	53	2	19454	50	ZBTB20,AHCYL2
8.218e-03	-4.80	cysteine transport	biological process	GO:0042883	3	1	18204	50	SLC1A2
8.218e-03	-4.80	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	50	CTNNA2
8.218e-03	-4.80	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	50	NEBL
8.218e-03	-4.80	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	50	ATP1A2
8.218e-03	-4.80	cell communication by chemical coupling	biological process	GO:0010643	3	1	18204	50	GJA1
8.218e-03	-4.80	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	50	SLC1A2
8.343e-03	-4.79	KLRC1 (killer cell lectin like receptor C1)	protein interactions	3821	162	3	19454	50	LRIG1,PON2,SFXN5
8.406e-03	-4.78	Sorb	pfam domains	PF02208	3	1	17795	50	SORBS1
8.406e-03	-4.78	RR_TM4-6	pfam domains	PF06459	3	1	17795	50	RYR3
8.406e-03	-4.78	RyR	pfam domains	PF02026	3	1	17795	50	RYR3
8.406e-03	-4.78	RYDR_Jsol	pfam domains	PF21119	3	1	17795	50	RYR3
8.406e-03	-4.78	SR_plectin_7	pfam domains	PF21097	3	1	17795	50	MACF1
8.406e-03	-4.78	Myelin_PLP	pfam domains	PF01275	3	1	17795	50	GPM6A
8.406e-03	-4.78	AdoHcyase_NAD	pfam domains	PF00670	3	1	17795	50	AHCYL2
8.406e-03	-4.78	AdoHcyase	pfam domains	PF05221	3	1	17795	50	AHCYL2
8.406e-03	-4.78	Arylesterase	pfam domains	PF01731	3	1	17795	50	PON2
8.446e-03	-4.77	CATATPASE	prints domains	PR00119	35	2	5227	21	ATP13A4,ATP1A2
8.507e-03	-4.77	TAFA4 (TAFA chemokine like family member 4)	protein interactions	151647	54	2	19454	50	LIFR,ITPR2
8.603e-03	-4.76	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-temporoparietal-glioma-astrocytoma_Grade_IV	48	2	16828	49	PARD3,RYR3
8.627e-03	-4.75	SCYL1 (SCY1 like pseudokinase 1)	protein interactions	57410	164	3	19454	50	MACF1,GJA1,MEIS2
8.693e-03	-4.75	cellular response to organic cyclic compound	biological process	GO:0071407	464	5	18204	50	SLC1A2,ATP1A2,SLC1A3,RYR3,ITPR2
8.702e-03	-4.74	calcium-mediated signaling	biological process	GO:0019722	154	3	18204	50	ATP1A2,RYR3,ITPR2
8.711e-03	-4.74	skin-leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-leg-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-lentigo	COSMIC cancer mutations	skin-leg-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-hand-lentigo	COSMIC cancer mutations	skin-hand-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-lentigo	COSMIC cancer mutations	skin-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-trunk-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-lentigo	COSMIC cancer mutations	skin-trunk-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	urinary_tract-bladder-papilloma	COSMIC cancer mutations	urinary_tract-bladder-papilloma	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-face-lentigo	COSMIC cancer mutations	skin-face-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-forearm-lentigo	COSMIC cancer mutations	skin-forearm-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	lentigo	COSMIC cancer mutations	lentigo	3	1	16828	49	FGFR3
8.712e-03	-4.74	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	48	ATP1A2,ATP13A4
8.726e-03	-4.74	c-src mediated regulation of Cx43 function and closure of gap junctions	REACTOME pathways	R-HSA-191647	3	1	10285	30	GJA1
8.726e-03	-4.74	Oligomerization of connexins into connexons	REACTOME pathways	R-HSA-190704	3	1	10285	30	GJA1
8.726e-03	-4.74	Transport of connexins along the secretory pathway	REACTOME pathways	R-HSA-190827	3	1	10285	30	GJA1
8.726e-03	-4.74	Regulation of gap junction activity	REACTOME pathways	R-HSA-191650	3	1	10285	30	GJA1
8.748e-03	-4.74	ZYX (zyxin)	protein interactions	7791	316	4	19454	50	NEBL,SORBS1,MACF1,ABLIM1
8.771e-03	-4.74	EGR2 (early growth response 2)	protein interactions	1959	165	3	19454	50	TRPS1,NFIA,SOX5
8.814e-03	-4.73	AMPH (amphiphysin)	protein interactions	273	55	2	19454	50	GLUL,GPM6A
8.873e-03	-4.72	muscle system process	biological process	GO:0003012	297	4	18204	50	DTNA,RYR3,ATP1A2,GJA1
8.873e-03	-4.72	carboxylic acid transport	biological process	GO:0046942	297	4	18204	50	GJA1,SLC1A2,SFXN5,SLC1A3
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	ABLIM1,ATP1A2,NEBL
8.976e-03	-4.71	organic acid transport	biological process	GO:0015849	298	4	18204	50	GJA1,SLC1A2,SLC1A3,SFXN5
8.982e-03	-4.71	regulation of nucleotide catabolic process	biological process	GO:0030811	52	2	18204	50	ZBTB20,SLC4A4
8.982e-03	-4.71	regulation of glycolytic process	biological process	GO:0006110	52	2	18204	50	ZBTB20,SLC4A4
8.982e-03	-4.71	regulation of purine nucleotide catabolic process	biological process	GO:0033121	52	2	18204	50	ZBTB20,SLC4A4
9.013e-03	-4.71	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	50	GPM6A,BMPR1B,NFIA
9.095e-03	-4.70	-	gene3d domains	1.10.490.160	3	1	14470	44	RYR3
9.095e-03	-4.70	Reeler domain	gene3d domains	2.60.40.4060	3	1	14470	44	SPON1
9.095e-03	-4.70	-	gene3d domains	6.10.250.2510	3	1	14470	44	CTNNA2
9.095e-03	-4.70	Adenosylhomocysteinase-like	gene3d domains	3.40.50.1480	3	1	14470	44	AHCYL2
9.185e-03	-4.69	SLC-mediated transmembrane transport	REACTOME pathways	R-HSA-425407	287	4	10285	30	SLC1A3,AHCYL2,SLC4A4,SLC1A2
9.191e-03	-4.69	EF-hand	gene3d domains	1.10.238.10	272	4	14470	44	RYR3,MACF1,SPARCL1,DTNA
9.212e-03	-4.69	POU2F1 (POU class 2 homeobox 1)	protein interactions	5451	168	3	19454	50	LIFR,SOX5,GPC5
9.318e-03	-4.68	EGFR (epidermal growth factor receptor)	protein interactions	1956	3105	15	19454	50	PON2,SORBS1,GLUL,CTNND2,DTNA,LIFR,CTNNA2,SPARCL1,ABLIM1,TRPS1,PARD3,LRIG1,GJA1,TNIK,AHCYL2
9.318e-03	-4.68	neutral amino acid transport	biological process	GO:0015804	53	2	18204	50	SLC1A2,SLC1A3
9.428e-03	-4.66	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	10	16828	49	SORBS1,GPC5,MACF1,PTPRZ1,PREX2,FGFR3,NPAS3,DTNA,RYR3,PARD3B
9.492e-03	-4.66	monoatomic anion transport	biological process	GO:0006820	159	3	18204	50	SLC4A4,SLC1A2,SLC1A3
9.564e-03	-4.65	side of membrane	cellular component	GO:0098552	715	6	19108	49	GPC5,DTNA,LIFR,NTM,AQP4,LSAMP
9.597e-03	-4.65	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	30	SLC1A2,SLC1A3
9.665e-03	-4.64	PPFIBP1 (PPFIA binding protein 1)	protein interactions	8496	171	3	19454	50	PARD3,MEIS2,GJA1
9.665e-03	-4.64	TLX1 (T cell leukemia homeobox 1)	protein interactions	3195	171	3	19454	50	TRPS1,NFIA,MEIS2
9.762e-03	-4.63	Hippo signaling pathway	KEGG pathways	hsa04390	154	3	7161	21	BMPR1B,PARD3,CTNNA2
9.762e-03	-4.63	Hippo signaling pathway	KEGG pathways	ko04390	154	3	7161	21	CTNNA2,BMPR1B,PARD3
9.763e-03	-4.63	CACHD1 (cache domain containing 1)	protein interactions	57685	58	2	19454	50	GJA1,PON2
9.763e-03	-4.63	HOXB6 (homeobox B6)	protein interactions	3216	58	2	19454	50	AHCYL2,GLUL
9.858e-03	-4.62	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	6	16828	49	NFIA,NEBL,PREX2,PTPRZ1,SORBS1,NTM
1.001e-02	-4.60	establishment or maintenance of epithelial cell apical/basal polarity	biological process	GO:0045197	55	2	18204	50	PARD3B,PARD3
1.001e-02	-4.60	response to cocaine	biological process	GO:0042220	55	2	18204	50	SLC1A2,SLC1A3
1.009e-02	-4.60	MARVELD2 (MARVEL domain containing 2)	protein interactions	153562	59	2	19454	50	GJA1,PARD3
1.017e-02	-4.59	RHOA (ras homolog family member A)	protein interactions	387	1186	8	19454	50	MACF1,PARD3B,PREX2,PON2,PARD3,ITPR2,CTNNA2,GJA1
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	DTNA,CDH20,CTNNA2
1.022e-02	-4.58	internode region of axon	cellular component	GO:0033269	4	1	19108	49	PARD3
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ctbp2 (C-terminal binding protein 2)	protein interactions	13017	4	1	19454	50	TRPS1
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.025e-02	-4.58	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	26	16828	49	ABLIM1,SLC1A3,TRPS1,GPC5,GPM6A,LRIG1,PON2,PREX2,SPARCL1,DTNA,PARD3B,CDH20,ATP1A2,ITPR2,NFIA,PARD3,ATP13A4,SLC4A4,NEBL,FGFR3,PTPRZ1,RFX4,SFXN5,SORBS1,ZBTB20,MACF1
1.029e-02	-4.58	LHX3 (LIM homeobox 3)	protein interactions	8022	175	3	19454	50	SOX5,NFIA,TRPS1
1.030e-02	-4.58	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	26	16828	49	TRPS1,SLC1A3,ABLIM1,LRIG1,GPC5,GPM6A,PON2,SPARCL1,PREX2,PARD3B,DTNA,ITPR2,ATP1A2,CDH20,NFIA,PARD3,ATP13A4,SLC4A4,NEBL,RFX4,FGFR3,PTPRZ1,SORBS1,SFXN5,MACF1,ZBTB20
1.034e-02	-4.57	NR3C1 (nuclear receptor subfamily 3 group C member 1)	protein interactions	2908	950	7	19454	50	ZBTB20,SLC1A3,NFIA,ATP13A4,TRPS1,PON2,CTNND2
1.034e-02	-4.57	channel activity	molecular function	GO:0015267	502	5	18094	48	GJA1,GPM6A,AQP4,RYR3,ITPR2
1.036e-02	-4.57	cardiac muscle cell action potential	biological process	GO:0086001	56	2	18204	50	ATP1A2,GJA1
1.036e-02	-4.57	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	50	ITPR2,RYR3
1.041e-02	-4.56	-	gene3d domains	2.30.42.10	149	3	14470	44	PREX2,PARD3,PARD3B
1.042e-02	-4.56	SNTB1 (syntrophin beta 1)	protein interactions	6641	60	2	19454	50	DTNA,FGFR3
1.042e-02	-4.56	LRIG2 (leucine rich repeats and immunoglobulin like domains 2)	protein interactions	9860	60	2	19454	50	PON2,LRIG1
1.042e-02	-4.56	passive transmembrane transporter activity	molecular function	GO:0022803	503	5	18094	48	AQP4,GPM6A,GJA1,ITPR2,RYR3
1.043e-02	-4.56	actin cytoskeleton	cellular component	GO:0015629	520	5	19108	49	ABLIM1,MACF1,NEBL,SORBS1,CTNNA2
1.049e-02	-4.56	import across plasma membrane	biological process	GO:0098739	165	3	18204	50	SLC1A3,ATP1A2,SLC1A2
1.050e-02	-4.56	response to light stimulus	biological process	GO:0009416	312	4	18204	50	SLC1A3,SLC1A2,MEIS2,ATP1A2
1.057e-02	-4.55	tricarboxylic acid transmembrane transporter activity	molecular function	GO:0015142	4	1	18094	48	SFXN5
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.057e-02	-4.55	ciliary neurotrophic factor receptor activity	molecular function	GO:0004897	4	1	18094	48	LIFR
1.057e-02	-4.55	citrate transmembrane transporter activity	molecular function	GO:0015137	4	1	18094	48	SFXN5
1.071e-02	-4.54	sulfur compound transmembrane transporter activity	molecular function	GO:1901682	59	2	18094	48	GJA1,SLC1A2
1.072e-02	-4.54	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	50	ITPR2,RYR3
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	PKNOX/Meis_N	interpro domains	IPR032453	4	1	18521	50	MEIS2
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	FGF_rcpt_fam	interpro domains	IPR016248	4	1	18521	50	FGFR3
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.079e-02	-4.53	ADOHCYASE_1	prosite domains	PS00738	3	1	12186	44	AHCYL2
1.079e-02	-4.53	ADOHCYASE_2	prosite domains	PS00739	3	1	12186	44	AHCYL2
1.079e-02	-4.53	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	44	GPM6A
1.079e-02	-4.53	SOHO	prosite domains	PS50831	3	1	12186	44	SORBS1
1.079e-02	-4.53	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	44	GPM6A
1.079e-02	-4.53	REELIN	prosite domains	PS51019	3	1	12186	44	SPON1
1.079e-02	-4.53	VINCULIN_1	prosite domains	PS00663	3	1	12186	44	CTNNA2
1.085e-02	-4.52	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	39	16828	49	PON2,LRIG1,GPM6A,GPC5,TRPS1,NPAS3,SLC1A3,CPE,FBXL7,ABLIM1,ITPR2,ATP1A2,AHCYL2,CDH20,NKAIN3,AQP4,LSAMP,DTNA,RYR3,TNIK,SOX5,SPARCL1,PREX2,NEBL,SPON1,MEIS2,ATP13A4,GLUL,PARD3,MACF1,ZBTB20,NHSL1,SORBS1,SFXN5,SLC1A2,CTNND2,RFX4,PTPRZ1,FGFR3
1.094e-02	-4.52	positive regulation of striated muscle tissue development	biological process	GO:0045844	4	1	18204	50	GJA1
1.094e-02	-4.52	response to glycoside	biological process	GO:1903416	4	1	18204	50	ATP1A2
1.094e-02	-4.52	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	50	ATP1A2
1.094e-02	-4.52	oncostatin-M-mediated signaling pathway	biological process	GO:0038165	4	1	18204	50	LIFR
1.094e-02	-4.52	positive regulation of muscle organ development	biological process	GO:0048636	4	1	18204	50	GJA1
1.094e-02	-4.52	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	50	SOX5
1.094e-02	-4.52	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	50	BMPR1B
1.094e-02	-4.52	protein localization to secretory granule	biological process	GO:0033366	4	1	18204	50	CPE
1.094e-02	-4.52	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	50	ATP1A2
1.094e-02	-4.52	positive regulation of cardiac muscle myoblast proliferation	biological process	GO:0110024	4	1	18204	50	MEIS2
1.094e-02	-4.52	leukemia inhibitory factor signaling pathway	biological process	GO:0048861	4	1	18204	50	LIFR
1.094e-02	-4.52	positive regulation of mesodermal cell differentiation	biological process	GO:1905772	4	1	18204	50	GJA1
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	PREX2,SPARCL1,DTNA,RYR3,PARD3B,AHCYL2,CDH20,ITPR2,LIFR,TRPS1,CPE,SLC1A3,FBXL7,LRIG1,GPM6A,GPC5,MSI2,RFX4,SORBS1,SFXN5,PITPNC1,NHSL1,ATP13A4,MEIS2,ZNRF3,SLC4A4,TNIK,SOX5,LSAMP,AQP4,NKAIN3,ATP1A2,NFIA,ABLIM1,NPAS3,NTM,PON2,PTPRZ1,FGFR3,BMPR1B,SLC1A2,GJA1,CTNND2,ZBTB20,MACF1,PARD3,GLUL,SPON1,NEBL
1.118e-02	-4.49	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	49	GPC5,TRPS1,RYR3,MACF1
1.119e-02	-4.49	Spectrin_2	pfam domains	PF18373	4	1	17795	50	MACF1
1.119e-02	-4.49	NHS	pfam domains	PF15273	4	1	17795	50	NHSL1
1.119e-02	-4.49	Spectrin_4	pfam domains	PF21020	4	1	17795	50	MACF1
1.119e-02	-4.49	Nebulin	pfam domains	PF00880	4	1	17795	50	NEBL
1.119e-02	-4.49	AbLIM_anchor	pfam domains	PF16182	4	1	17795	50	ABLIM1
1.119e-02	-4.49	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	50	NFIA
1.119e-02	-4.49	NKAIN	pfam domains	PF05640	4	1	17795	50	NKAIN3
1.119e-02	-4.49	Spectrin_3	pfam domains	PF21019	4	1	17795	50	MACF1
1.119e-02	-4.49	P5-ATPase	pfam domains	PF12409	4	1	17795	50	ATP13A4
1.119e-02	-4.49	Meis_PKNOX_N	pfam domains	PF16493	4	1	17795	50	MEIS2
1.119e-02	-4.49	CTF_NFI	pfam domains	PF00859	4	1	17795	50	NFIA
1.138e-02	-4.48	head_neck	COSMIC cancer mutations	head_neck	15361	49	16828	49	SPON1,NEBL,PARD3,GLUL,MACF1,ZBTB20,GJA1,SLC1A2,CTNND2,PTPRZ1,BMPR1B,FGFR3,NTM,PON2,NPAS3,ABLIM1,ATP1A2,NKAIN3,AQP4,NFIA,TNIK,SOX5,LSAMP,SLC4A4,ZNRF3,MEIS2,ATP13A4,SORBS1,SFXN5,PITPNC1,NHSL1,RFX4,LRIG1,GPM6A,GPC5,MSI2,TRPS1,CPE,SLC1A3,FBXL7,ITPR2,LIFR,CDH20,AHCYL2,SPARCL1,PREX2,PARD3B,DTNA,RYR3
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.144e-02	-4.47	NAXD (NAD(P)HX dehydratase)	protein interactions	55739	63	2	19454	50	NEBL,PON2
1.145e-02	-4.47	establishment or maintenance of apical/basal cell polarity	biological process	GO:0035088	59	2	18204	50	PARD3,PARD3B
1.145e-02	-4.47	endochondral bone morphogenesis	biological process	GO:0060350	59	2	18204	50	FGFR3,BMPR1B
1.145e-02	-4.47	establishment or maintenance of bipolar cell polarity	biological process	GO:0061245	59	2	18204	50	PARD3B,PARD3
1.160e-02	-4.46	inverted	COSMIC cancer mutations	inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-benign_melanocytic_nevus-junctional	COSMIC cancer mutations	skin-benign_melanocytic_nevus-junctional	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-papilloma-inverted	COSMIC cancer mutations	urinary_tract-bladder-papilloma-inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.160e-02	-4.46	urinary_tract-bladder-other-normal	COSMIC cancer mutations	urinary_tract-bladder-other-normal	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.160e-02	-4.46	synapse	cellular component	GO:0045202	1473	9	19108	49	TNIK,SLC1A2,SPARCL1,PTPRZ1,GPM6A,ATP1A2,SLC1A3,CTNND2,DTNA
1.166e-02	-4.45	Bile Acid Indirect Signalling Pathway	SMPDB pathways	SMP0086851	8	1	1369	2	FGFR3
1.167e-02	-4.45	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	162	3	16828	49	ITPR2,RYR3,MACF1
1.169e-02	-4.45	AdoHcyase	smart domains	SM00996	3	1	9717	38	AHCYL2
1.169e-02	-4.45	Sorb	smart domains	SM00459	3	1	9717	38	SORBS1
1.169e-02	-4.45	AdoHcyase_NAD	smart domains	SM00997	3	1	9717	38	AHCYL2
1.169e-02	-4.45	PLP	smart domains	SM00002	3	1	9717	38	GPM6A
1.171e-02	-4.45	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	40	16828	49	TNIK,SPARCL1,SOX5,PREX2,PARD3B,LSAMP,RYR3,DTNA,LIFR,ITPR2,ATP1A2,AHCYL2,CDH20,NKAIN3,NFIA,NPAS3,CPE,FBXL7,SLC1A3,ABLIM1,LRIG1,NTM,GPC5,PON2,MSI2,SLC1A2,CTNND2,RFX4,PTPRZ1,BMPR1B,FGFR3,SFXN5,MACF1,NHSL1,PARD3,ATP13A4,SLC4A4,SPON1,MEIS2,NEBL
1.178e-02	-4.44	TMEM87A (transmembrane protein 87A)	protein interactions	25963	184	3	19454	50	FGFR3,CPE,GJA1
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	TRPS1,NFIA
1.182e-02	-4.44	protein homotetramerization	biological process	GO:0051289	60	2	18204	50	RYR3,AQP4
1.182e-02	-4.44	regulation of glucose import	biological process	GO:0046324	60	2	18204	50	SORBS1,SLC1A2
1.184e-02	-4.44	cadherin binding	molecular function	GO:0045296	335	4	18094	48	CDH20,CTNND2,MACF1,CTNNA2
1.184e-02	-4.44	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	27	16828	49	LIFR,CDH20,PARD3B,RYR3,SOX5,PREX2,NTM,GPC5,GPM6A,TRPS1,NPAS3,SLC1A3,FBXL7,ABLIM1,MACF1,ZBTB20,PITPNC1,NHSL1,SORBS1,SFXN5,SLC1A2,CTNND2,RFX4,FGFR3,SLC4A4,SPON1,PARD3
1.192e-02	-4.43	chemical homeostasis	biological process	GO:0048878	914	7	18204	50	SLC4A4,ZBTB20,RYR3,ATP1A2,SLC1A3,ATP13A4,AQP4
1.199e-02	-4.42	response to organonitrogen compound	biological process	GO:0010243	915	7	18204	50	RYR3,SORBS1,GJA1,TNIK,ITPR2,SLC1A3,SLC1A2
1.201e-02	-4.42	MYELINPLP	prints domains	PR00214	3	1	5227	21	GPM6A
1.201e-02	-4.42	RYANODINER	prints domains	PR00795	3	1	5227	21	RYR3
1.201e-02	-4.42	INSP3RECEPTR	prints domains	PR00779	3	1	5227	21	ITPR2
1.201e-02	-4.42	PARAOXONASE	prints domains	PR01785	3	1	5227	21	PON2
1.205e-02	-4.42	TRIM67 (tripartite motif containing 67)	protein interactions	440730	4804	20	19454	50	GLUL,PITPNC1,CTNND2,NTM,PON2,CTNNA2,DTNA,SLC1A3,PTPRZ1,MACF1,TNIK,LSAMP,PARD3,LRIG1,SLC4A4,ATP1A2,ITPR2,MSI2,AHCYL2,GPM6A
1.209e-02	-4.42	kidney	COSMIC cancer mutations	kidney	15380	49	16828	49	CDH20,AHCYL2,ITPR2,LIFR,PREX2,SPARCL1,DTNA,RYR3,PARD3B,GPC5,GPM6A,LRIG1,MSI2,CPE,SLC1A3,FBXL7,TRPS1,SFXN5,SORBS1,PITPNC1,NHSL1,RFX4,MEIS2,SLC4A4,ZNRF3,ATP13A4,NKAIN3,AQP4,ATP1A2,NFIA,SOX5,TNIK,LSAMP,NTM,PON2,ABLIM1,NPAS3,ZBTB20,MACF1,BMPR1B,FGFR3,PTPRZ1,CTNND2,GJA1,SLC1A2,SPON1,NEBL,PARD3,GLUL
1.211e-02	-4.41	-	gene3d domains	1.20.58.1060	4	1	14470	44	MACF1
1.216e-02	-4.41	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	49	RYR3,MACF1,TRPS1,GPM6A,GPC5
1.219e-02	-4.41	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	9	16828	49	ATP1A2,NTM,SLC4A4,SORBS1,MACF1,ZBTB20,TRPS1,NPAS3,PARD3B
1.223e-02	-4.40	monoatomic cation homeostasis	biological process	GO:0055080	505	5	18204	50	ATP13A4,RYR3,SLC1A3,SLC4A4,ATP1A2
1.229e-02	-4.40	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	30	ATP1A2,ATP13A4
1.229e-02	-4.40	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	39	16828	49	GLUL,ATP13A4,PARD3,NEBL,MEIS2,SLC4A4,ZNRF3,PTPRZ1,FGFR3,BMPR1B,GJA1,SLC1A2,CTNND2,ZBTB20,NHSL1,MACF1,SORBS1,SFXN5,TRPS1,NPAS3,FBXL7,CPE,SLC1A3,MSI2,NTM,LRIG1,GPC5,RYR3,LSAMP,DTNA,PARD3B,PREX2,TNIK,SOX5,CDH20,AHCYL2,ITPR2,LIFR,ATP1A2
1.248e-02	-4.38	HNF1B (HNF1 homeobox B)	protein interactions	6928	188	3	19454	50	SOX5,NFIA,TRPS1
1.249e-02	-4.38	back	COSMIC cancer mutations	back	310	4	16828	49	FGFR3,PREX2,ATP1A2,TNIK
1.250e-02	-4.38	MICB (MHC class I polypeptide-related sequence B)	protein interactions	4277	66	2	19454	50	GJA1,SFXN5
1.252e-02	-4.38	circulatory system process	biological process	GO:0003013	508	5	18204	50	SLC4A4,GJA1,SLC1A2,ATP1A2,SLC1A3
1.259e-02	-4.38	regulation of carbohydrate catabolic process	biological process	GO:0043470	62	2	18204	50	SLC4A4,ZBTB20
1.259e-02	-4.38	sulfur compound transport	biological process	GO:0072348	62	2	18204	50	GJA1,SLC1A2
1.262e-02	-4.37	Ig-like_fold	interpro domains	IPR013783	721	6	18521	50	LRIG1,LIFR,FGFR3,LSAMP,PTPRZ1,NTM
1.266e-02	-4.37	peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	peripheral_T_cell_lymphoma_unspecified	167	3	16828	49	RYR3,MACF1,ITPR2
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	TRH (thyrotropin releasing hormone)	protein interactions	7200	5	1	19454	50	CPE
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	ARSI (arylsulfatase family member I)	protein interactions	340075	5	1	19454	50	AHCYL2
1.287e-02	-4.35	EFR3B (EFR3 homolog B)	protein interactions	22979	67	2	19454	50	PARD3,GJA1
1.291e-02	-4.35	VIRMA (vir like m6A methyltransferase associated)	protein interactions	25962	2914	14	19454	50	ZBTB20,MACF1,ZNRF3,LIFR,GLUL,NHSL1,SORBS1,PON2,PARD3B,ITPR2,ABLIM1,TNIK,PARD3,TRPS1
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	PREX2,SPARCL1,RYR3,PARD3B,CDH20,AHCYL2,LIFR,ITPR2,FBXL7,CPE,SLC1A3,TRPS1,GPM6A,GPC5,LRIG1,MSI2,RFX4,SFXN5,SORBS1,NHSL1,PITPNC1,ATP13A4,MEIS2,SLC4A4,ZNRF3,SOX5,TNIK,LSAMP,NKAIN3,AQP4,ATP1A2,NFIA,ABLIM1,NPAS3,NTM,PON2,FGFR3,BMPR1B,PTPRZ1,CTNND2,SLC1A2,GJA1,ZBTB20,MACF1,PARD3,GLUL,SPON1,NEBL
1.308e-02	-4.34	synapse organization	biological process	GO:0050808	333	4	18204	50	CTNND2,GPM6A,SPARCL1,NFIA
1.314e-02	-4.33	inorganic ion transmembrane transport	biological process	GO:0098660	715	6	18204	50	ITPR2,RYR3,SLC1A3,ATP1A2,GPM6A,SLC4A4
1.317e-02	-4.33	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	3	18094	48	SLC1A2,SFXN5,SLC1A3
1.318e-02	-4.33	main axon	cellular component	GO:0044304	68	2	19108	49	PARD3,SLC1A2
1.320e-02	-4.33	gap junction channel activity involved in cardiac conduction electrical coupling	molecular function	GO:0086075	5	1	18094	48	GJA1
1.320e-02	-4.33	glutathione transmembrane transporter activity	molecular function	GO:0034634	5	1	18094	48	GJA1
1.320e-02	-4.33	fibroblast growth factor receptor activity	molecular function	GO:0005007	5	1	18094	48	FGFR3
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.322e-02	-4.33	monoatomic ion homeostasis	biological process	GO:0050801	515	5	18204	50	RYR3,ATP13A4,SLC1A3,SLC4A4,ATP1A2
1.324e-02	-4.32	MARK1 (microtubule affinity regulating kinase 1)	protein interactions	4139	68	2	19454	50	GJA1,DTNA
1.324e-02	-4.32	PLCH1 (phospholipase C eta 1)	protein interactions	23007	68	2	19454	50	PARD3,GJA1
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A3,SLC1A2
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.335e-02	-4.32	camera-type eye development	biological process	GO:0043010	335	4	18204	50	NFIA,GJA1,BMPR1B,GPM6A
1.336e-02	-4.32	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	3	18094	48	SFXN5,SLC1A3,SLC1A2
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.343e-02	-4.31	Mtc	interpro domains	IPR004686	5	1	18521	50	SFXN5
1.346e-02	-4.31	cell-cell junction organization	biological process	GO:0045216	181	3	18204	50	GJA1,PARD3,CDH20
1.352e-02	-4.30	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	17	16828	49	ATP13A4,PARD3,NEBL,SPON1,GPC5,LRIG1,MEIS2,CTNND2,FGFR3,PREX2,PTPRZ1,RFX4,MACF1,PITPNC1,ATP1A2,LIFR,ITPR2
1.355e-02	-4.30	SH3_9	pfam domains	PF14604	63	2	17795	50	NEBL,SORBS1
1.359e-02	-4.30	Axon guidance	KEGG pathways	ko04360	174	3	7161	21	BMPR1B,PARD3,ABLIM1
1.359e-02	-4.30	Axon guidance	KEGG pathways	hsa04360	174	3	7161	21	ABLIM1,PARD3,BMPR1B
1.363e-02	-4.30	temporoparietal	COSMIC cancer mutations	temporoparietal	61	2	16828	49	RYR3,PARD3
1.366e-02	-4.29	amygdala development	biological process	GO:0021764	5	1	18204	50	ATP1A2
1.366e-02	-4.29	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	50	BMPR1B
1.366e-02	-4.29	ciliary neurotrophic factor-mediated signaling pathway	biological process	GO:0070120	5	1	18204	50	LIFR
1.366e-02	-4.29	tricarboxylic acid transport	biological process	GO:0006842	5	1	18204	50	SFXN5
1.366e-02	-4.29	citrate transport	biological process	GO:0015746	5	1	18204	50	SFXN5
1.366e-02	-4.29	otolith morphogenesis	biological process	GO:0032474	5	1	18204	50	LRIG1
1.368e-02	-4.29	IGc2	smart domains	SM00408	239	4	9717	38	LRIG1,LSAMP,FGFR3,NTM
1.377e-02	-4.29	regulation of protein processing	biological process	GO:0070613	65	2	18204	50	SPON1,RFX4
1.386e-02	-4.28	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	3	18204	50	SORBS1,SLC4A4,ZBTB20
1.389e-02	-4.28	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	50	ZNRF3,GPC5,MACF1,CTNND2
1.392e-02	-4.27	extracellular matrix	cellular component	GO:0031012	559	5	19108	49	SPON1,SPARCL1,PTPRZ1,LRIG1,GPC5
1.397e-02	-4.27	IP_trans	pfam domains	PF02121	5	1	17795	50	PITPNC1
1.397e-02	-4.27	SFXNs	pfam domains	PF03820	5	1	17795	50	SFXN5
1.397e-02	-4.27	Vinculin	pfam domains	PF01044	5	1	17795	50	CTNNA2
1.397e-02	-4.27	FOLN	pfam domains	PF09289	5	1	17795	50	SPARCL1
1.399e-02	-4.27	PCDH20 (protocadherin 20)	protein interactions	64881	70	2	19454	50	CTNNA2,PON2
1.400e-02	-4.27	adenoma	COSMIC cancer mutations	adenoma	2873	15	16828	49	NEBL,GPM6A,GPC5,PARD3,NPAS3,ZBTB20,MACF1,CDH20,LIFR,RYR3,FGFR3,BMPR1B,PTPRZ1,CTNND2,SOX5
1.402e-02	-4.27	external encapsulating structure	cellular component	GO:0030312	560	5	19108	49	GPC5,LRIG1,PTPRZ1,SPARCL1,SPON1
1.408e-02	-4.26	cell population proliferation	biological process	GO:0008283	726	6	18204	50	GLUL,ZNRF3,NFIA,FGFR3,GJA1,SOX5
1.418e-02	-4.26	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	49	SLC4A4,ZNRF3,MEIS2,ATP13A4,SORBS1,SFXN5,NHSL1,PITPNC1,RFX4,LRIG1,GPC5,GPM6A,TRPS1,SLC1A3,FBXL7,CPE,LIFR,ITPR2,AHCYL2,CDH20,SPARCL1,PREX2,PARD3B,DTNA,RYR3,SPON1,NEBL,PARD3,GLUL,MACF1,ZBTB20,GJA1,SLC1A2,CTNND2,BMPR1B,PTPRZ1,FGFR3,NTM,PON2,NPAS3,ABLIM1,ATP1A2,AQP4,NKAIN3,NFIA,TNIK,SOX5,LSAMP
1.418e-02	-4.26	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	49	GLUL,PARD3,NEBL,SPON1,GJA1,SLC1A2,CTNND2,PTPRZ1,FGFR3,BMPR1B,MACF1,ZBTB20,NPAS3,ABLIM1,PON2,NTM,LSAMP,TNIK,SOX5,NFIA,ATP1A2,AQP4,NKAIN3,ATP13A4,SLC4A4,ZNRF3,MEIS2,RFX4,NHSL1,PITPNC1,SORBS1,SFXN5,TRPS1,CPE,FBXL7,SLC1A3,LRIG1,GPM6A,GPC5,PARD3B,RYR3,DTNA,SPARCL1,PREX2,LIFR,ITPR2,AHCYL2,CDH20
1.418e-02	-4.26	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	50	SLC1A3,SLC1A2
1.425e-02	-4.25	DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5)	protein interactions	80331	365	4	19454	50	DTNA,MACF1,GJA1,PARD3
1.427e-02	-4.25	response to growth factor	biological process	GO:0070848	525	5	18204	50	NFIA,FGFR3,SOX5,BMPR1B,MEIS2
1.433e-02	-4.25	NFIX (nuclear factor I X)	protein interactions	4784	198	3	19454	50	NFIA,TRPS1,SOX5
1.433e-02	-4.25	CAMK2D (calcium/calmodulin dependent protein kinase II delta)	protein interactions	817	198	3	19454	50	PON2,ITPR2,FGFR3
1.437e-02	-4.24	CTF_NFI_1	prosite domains	PS00349	4	1	12186	44	NFIA
1.437e-02	-4.24	CTF_NFI_2	prosite domains	PS51080	4	1	12186	44	NFIA
1.437e-02	-4.24	NEBULIN	prosite domains	PS51216	4	1	12186	44	NEBL
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	PARD3,MACF1
1.437e-02	-4.24	TSPAN17 (tetraspanin 17)	protein interactions	26262	71	2	19454	50	GJA1,GPM6A
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	GPM6A,TNIK
1.446e-02	-4.24	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	19	SLC1A3,ATP1A2
1.447e-02	-4.24	limb development	biological process	GO:0060173	186	3	18204	50	NFIA,ZNRF3,GJA1
1.447e-02	-4.24	appendage development	biological process	GO:0048736	186	3	18204	50	GJA1,ZNRF3,NFIA
1.448e-02	-4.24	syringocystadenoma_papilliferum	COSMIC cancer mutations	syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-lichenoid_keratosis	COSMIC cancer mutations	skin-shoulder-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-nevus_sebaceous	COSMIC cancer mutations	skin-shoulder-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	lichenoid_keratosis	COSMIC cancer mutations	lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-nevus_sebaceous	COSMIC cancer mutations	skin-breast-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-ear-other-nevus_sebaceous	COSMIC cancer mutations	skin-ear-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_arm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_arm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-lichenoid_keratosis	COSMIC cancer mutations	skin-face-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-adnexal_tumour-syringocystadenoma_papilliferum	COSMIC cancer mutations	skin-adnexal_tumour-syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-lichenoid_keratosis	COSMIC cancer mutations	skin-breast-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-lichenoid_keratosis	COSMIC cancer mutations	skin-neck-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-arm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-arm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-forearm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-flank-other-lichenoid_keratosis	COSMIC cancer mutations	skin-flank-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.448e-02	-4.24	skin-upper_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-nevus_sebaceous	COSMIC cancer mutations	skin-neck-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-nevus_sebaceous	COSMIC cancer mutations	skin-lower_back-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-other-lichenoid_keratosis	COSMIC cancer mutations	skin-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-scalp-other-nevus_sebaceous	COSMIC cancer mutations	skin-scalp-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hip-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-hip-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hand-other-lichenoid_keratosis	COSMIC cancer mutations	skin-hand-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-forearm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-nevus_sebaceous	COSMIC cancer mutations	skin-face-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-chest-other-lichenoid_keratosis	COSMIC cancer mutations	skin-chest-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.23	cell differentiation	biological process	GO:0030154	3645	17	18204	50	FGFR3,NHSL1,PREX2,SLC1A3,MSI2,GJA1,GPM6A,NTM,NFIA,CTNND2,NEBL,TNIK,SOX5,PTPRZ1,BMPR1B,PARD3,CTNNA2
1.451e-02	-4.23	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	50	AHCYL2,ABLIM1,TNIK,PARD3
1.460e-02	-4.23	cellular developmental process	biological process	GO:0048869	3648	17	18204	50	FGFR3,NHSL1,PREX2,SLC1A3,MSI2,GJA1,GPM6A,NTM,NFIA,CTNND2,TNIK,NEBL,SOX5,PTPRZ1,BMPR1B,PARD3,CTNNA2
1.475e-02	-4.22	PDZ	prosite domains	PS50106	143	3	12186	44	PREX2,PARD3B,PARD3
1.476e-02	-4.22	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	50	ABLIM1,PARD3
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	TNIK,GPM6A
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	BMPR1B,PARD3B
1.484e-02	-4.21	scaffold protein binding	molecular function	GO:0097110	70	2	18094	48	GJA1,ITPR2
1.508e-02	-4.19	upper_back	COSMIC cancer mutations	upper_back	328	4	16828	49	MACF1,PARD3B,FGFR3,GPC5
1.512e-02	-4.19	FEV (FEV transcription factor, ETS family member)	protein interactions	54738	202	3	19454	50	SOX5,TRPS1,NFIA
1.520e-02	-4.19	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	10	16828	49	LSAMP,ATP13A4,FGFR3,PTPRZ1,SOX5,TRPS1,MACF1,GPC5,ATP1A2,SLC4A4
1.529e-02	-4.18	PAR polarity complex	cellular component	GO:0120157	6	1	19108	49	PARD3
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	CYP39A1 (cytochrome P450 family 39 subfamily A member 1)	protein interactions	51302	6	1	19454	50	GLUL
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	FGF18 (fibroblast growth factor 18)	protein interactions	8817	6	1	19454	50	FGFR3
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	FGF6 (fibroblast growth factor 6)	protein interactions	2251	6	1	19454	50	FGFR3
1.532e-02	-4.18	TAT (tyrosine aminotransferase)	protein interactions	6898	6	1	19454	50	GLUL
1.532e-02	-4.18	FGF23 (fibroblast growth factor 23)	protein interactions	8074	6	1	19454	50	FGFR3
1.532e-02	-4.18	LIF (LIF interleukin 6 family cytokine)	protein interactions	3976	6	1	19454	50	LIFR
1.532e-02	-4.18	SAA4 (serum amyloid A4, constitutive)	protein interactions	6291	6	1	19454	50	GJA1
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	RSPO3 (R-spondin 3)	protein interactions	84870	6	1	19454	50	ZNRF3
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.543e-02	-4.17	regulation of protein maturation	biological process	GO:1903317	69	2	18204	50	RFX4,SPON1
1.547e-02	-4.17	cell-cell contact zone	cellular component	GO:0044291	74	2	19108	49	ATP1A2,GJA1
1.549e-02	-4.17	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	5	16828	49	FGFR3,SPARCL1,LIFR,NPAS3,ZBTB20
1.552e-02	-4.17	NFIC (nuclear factor I C)	protein interactions	4782	204	3	19454	50	SOX5,TRPS1,NFIA
1.554e-02	-4.16	CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1)	protein interactions	781	74	2	19454	50	GPM6A,PON2
1.555e-02	-4.16	NEBU	smart domains	SM00227	4	1	9717	38	NEBL
1.564e-02	-4.16	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	3	5310	19	RYR3,GJA1,ITPR2
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	NEBL,ABLIM1
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.581e-02	-4.15	gap junction hemi-channel activity	molecular function	GO:0055077	6	1	18094	48	GJA1
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.581e-02	-4.15	ciliary neurotrophic factor receptor binding	molecular function	GO:0005127	6	1	18094	48	LIFR
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.581e-02	-4.15	arylesterase activity	molecular function	GO:0004064	6	1	18094	48	PON2
1.585e-02	-4.14	cardiac conduction	biological process	GO:0061337	70	2	18204	50	ATP1A2,GJA1
1.594e-02	-4.14	UNC5B (unc-5 netrin receptor B)	protein interactions	219699	75	2	19454	50	GJA1,PARD3
1.594e-02	-4.14	CLRN2 (clarin 2)	protein interactions	645104	75	2	19454	50	GJA1,LRIG1
1.598e-02	-4.14	ALPHACATENIN	prints domains	PR00805	4	1	5227	21	CTNNA2
1.609e-02	-4.13	TSP1_spondin_dom	interpro domains	IPR044004	6	1	18521	50	SPON1
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.610e-02	-4.13	LIM	pfam domains	PF00412	69	2	17795	50	ABLIM1,NEBL
1.613e-02	-4.13	SNX6 (sorting nexin 6)	protein interactions	58533	207	3	19454	50	BMPR1B,GJA1,TNIK
1.613e-02	-4.13	MAGEA9 (MAGE family member A9)	protein interactions	4108	207	3	19454	50	NHSL1,ITPR2,MEIS2
1.618e-02	-4.12	protein homooligomerization	biological process	GO:0051260	194	3	18204	50	RYR3,AQP4,SLC1A2
1.627e-02	-4.12	sarcoplasmic reticulum	cellular component	GO:0016529	76	2	19108	49	RYR3,ITPR2
1.629e-02	-4.12	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	50	PARD3,FGFR3,BMPR1B,MACF1
1.635e-02	-4.11	KIAA1549 (KIAA1549)	protein interactions	57670	76	2	19454	50	PARD3,GJA1
1.637e-02	-4.11	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	50	SOX5
1.637e-02	-4.11	neuroblast migration	biological process	GO:0097402	6	1	18204	50	GJA1
1.637e-02	-4.11	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	50	SLC1A3
1.637e-02	-4.11	fused antrum stage	biological process	GO:0048165	6	1	18204	50	BMPR1B
1.637e-02	-4.11	intracellular water homeostasis	biological process	GO:0009992	6	1	18204	50	AQP4
1.640e-02	-4.11	bone development	biological process	GO:0060348	195	3	18204	50	FGFR3,GJA1,BMPR1B
1.672e-02	-4.09	regulation of ATP metabolic process	biological process	GO:1903578	72	2	18204	50	SLC4A4,ZBTB20
1.674e-02	-4.09	GAS2	pfam domains	PF02187	6	1	17795	50	MACF1
1.674e-02	-4.09	SH3_10	pfam domains	PF17902	6	1	17795	50	MACF1
1.674e-02	-4.09	Glypican	pfam domains	PF01153	6	1	17795	50	GPC5
1.674e-02	-4.09	TSP1_spondin	pfam domains	PF19028	6	1	17795	50	SPON1
1.674e-02	-4.09	EF-hand_3	pfam domains	PF09069	6	1	17795	50	DTNA
1.674e-02	-4.09	Plectin	pfam domains	PF00681	6	1	17795	50	MACF1
1.674e-02	-4.09	EF-hand_2	pfam domains	PF09068	6	1	17795	50	DTNA
1.675e-02	-4.09	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	50	NHSL1,SORBS1,SLC1A3
1.675e-02	-4.09	GOLGA4 (golgin A4)	protein interactions	2803	210	3	19454	50	MACF1,TNIK,GJA1
1.676e-02	-4.09	ADGRL2 (adhesion G protein-coupled receptor L2)	protein interactions	23266	77	2	19454	50	GJA1,PARD3
1.677e-02	-4.09	cellular response to organic substance	biological process	GO:0071310	1716	10	18204	50	SLC1A2,ATP1A2,SLC1A3,AQP4,ITPR2,ZBTB20,GJA1,LIFR,SORBS1,RYR3
1.696e-02	-4.08	CDK6 (cyclin dependent kinase 6)	protein interactions	1021	211	3	19454	50	SORBS1,FGFR3,SOX5
1.701e-02	-4.07	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	9	16828	49	FGFR3,CPE,CTNND2,RYR3,ATP13A4,PARD3B,ITPR2,ATP1A2,MACF1
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP13A4,ATP1A2
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.716e-02	-4.07	peptide metabolic process	biological process	GO:0006518	73	2	18204	50	SLC1A2,CPE
1.716e-02	-4.07	MARCKS (myristoylated alanine rich protein kinase C substrate)	protein interactions	4082	588	5	19454	50	AHCYL2,DTNA,ABLIM1,SLC1A3,MACF1
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	MSI2,SOX5
1.735e-02	-4.05	skin-arm-epidermal_nevus	COSMIC cancer mutations	skin-arm-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-face-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-face-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-benign_melanocytic_nevus-lentiginous_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus-lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	kidney-carcinoma-collecting_duct_carcinoma	COSMIC cancer mutations	kidney-carcinoma-collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-flank-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-flank-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_leg-epidermal_nevus	COSMIC cancer mutations	skin-lower_leg-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-upper_leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-upper_leg-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-abdomen-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-abdomen-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.735e-02	-4.05	skin-head_neck-epidermal_nevus	COSMIC cancer mutations	skin-head_neck-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-lower_back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-epidermal_nevus	COSMIC cancer mutations	skin-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	lentiginous_nevus	COSMIC cancer mutations	lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-adnexal_tumour-trichoblastoma	COSMIC cancer mutations	skin-adnexal_tumour-trichoblastoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	collecting_duct_carcinoma	COSMIC cancer mutations	collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-trunk-epidermal_nevus	COSMIC cancer mutations	skin-trunk-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-Bowen_disease	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-Bowen_disease	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-actinic_keratosis	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-actinic_keratosis	6	1	16828	49	FGFR3
1.738e-02	-4.05	signaling	biological process	GO:0023052	4968	21	18204	50	RYR3,GJA1,ZNRF3,PREX2,SPARCL1,ITPR2,SLC1A3,ATP1A2,FGFR3,PARD3,MACF1,CTNND2,BMPR1B,SORBS1,LIFR,TNIK,PITPNC1,DTNA,NFIA,SLC1A2,CPE
1.746e-02	-4.05	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	2	ATP1A2
1.746e-02	-4.05	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	2	ATP1A2
1.759e-02	-4.04	PRDM1 (PR/SET domain 1)	protein interactions	639	79	2	19454	50	NFIA,TRPS1
1.759e-02	-4.04	CANT1 (calcium activated nucleotidase 1)	protein interactions	124583	79	2	19454	50	GJA1,LRIG1
1.765e-02	-4.04	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	3	5310	19	RYR3,ITPR2,GJA1
1.768e-02	-4.04	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	7	16828	49	PREX2,BMPR1B,FGFR3,TNIK,MACF1,ATP1A2,ITPR2
1.776e-02	-4.03	M (membrane glycoprotein)	protein interactions	43740571	1057	7	19454	50	MACF1,PARD3B,GJA1,PON2,PARD3,ATP1A2,ABLIM1
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	FGF5 (fibroblast growth factor 5)	protein interactions	2250	7	1	19454	50	FGFR3
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Ahcyl1 (S-adenosylhomocysteine hydrolase-like 1)	protein interactions	229709	7	1	19454	50	AHCYL2
1.790e-02	-4.02	axonogenesis	biological process	GO:0007409	366	4	18204	50	CTNNA2,PARD3,BMPR1B,PTPRZ1
1.801e-02	-4.02	GPRIN1 (G protein regulated inducer of neurite outgrowth 1)	protein interactions	114787	80	2	19454	50	FGFR3,GJA1
1.804e-02	-4.01	ATP2B1 (ATPase plasma membrane Ca2+ transporting 1)	protein interactions	490	216	3	19454	50	FGFR3,GJA1,PARD3
1.806e-02	-4.01	amino acid biosynthetic process	biological process	GO:0008652	75	2	18204	50	GLUL,SLC1A3
1.808e-02	-4.01	PDZ	smart domains	SM00228	143	3	9717	38	PREX2,PARD3B,PARD3
1.811e-02	-4.01	Glutamine synthetase/guanido kinase, catalytic domain	gene3d domains	3.30.590.10	6	1	14470	44	GLUL
1.811e-02	-4.01	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	44	MACF1
1.811e-02	-4.01	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	44	MACF1
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	LBD domain binding	molecular function	GO:0050693	7	1	18094	48	SPON1
1.843e-02	-3.99	tripeptide transmembrane transporter activity	molecular function	GO:0042937	7	1	18094	48	GJA1
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	FAM135A (family with sequence similarity 135 member A)	protein interactions	57579	81	2	19454	50	GLUL,GJA1
1.843e-02	-3.99	SOX17 (SRY-box transcription factor 17)	protein interactions	64321	81	2	19454	50	TRPS1,NFIA
1.843e-02	-3.99	ARNT2 (aryl hydrocarbon receptor nuclear translocator 2)	protein interactions	9915	81	2	19454	50	MEIS2,NPAS3
1.847e-02	-3.99	regulation of multicellular organismal development	biological process	GO:2000026	1484	9	18204	50	GLUL,PARD3,MACF1,GJA1,TRPS1,SOX5,PTPRZ1,BMPR1B,MEIS2
1.851e-02	-3.99	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	hsa05412	72	2	7161	21	GJA1,CTNNA2
1.851e-02	-3.99	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	KEGG pathways	ko05412	72	2	7161	21	CTNNA2,GJA1
1.872e-02	-3.98	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	50	RYR3,ITPR2,GPM6A
1.872e-02	-3.98	establishment or maintenance of cell polarity	biological process	GO:0007163	205	3	18204	50	GJA1,PARD3,PARD3B
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	Aquaporin_transptr	interpro domains	IPR034294	7	1	18521	50	AQP4
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	Hematopoietin_rcpt_Gp130_CS	interpro domains	IPR003529	7	1	18521	50	LIFR
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP13A4,ATP1A2
1.884e-02	-3.97	extracellular region	cellular component	GO:0005576	4350	18	19108	49	PTPRZ1,ATP1A2,SLC4A4,PON2,GPC5,NEBL,SPARCL1,AQP4,CPE,LIFR,LRIG1,SPON1,TNIK,LSAMP,NTM,GPM6A,FGFR3,GLUL
1.886e-02	-3.97	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	19	GJA1,SLC1A3,AQP4
1.889e-02	-3.97	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	47	16828	49	NTM,PON2,ABLIM1,NPAS3,AQP4,NKAIN3,ATP1A2,NFIA,TNIK,SOX5,LSAMP,SPON1,NEBL,PARD3,ZBTB20,MACF1,PTPRZ1,BMPR1B,FGFR3,SLC1A2,CTNND2,LRIG1,GPM6A,GPC5,MSI2,TRPS1,CPE,FBXL7,SLC1A3,CDH20,AHCYL2,ITPR2,LIFR,PREX2,SPARCL1,DTNA,RYR3,PARD3B,MEIS2,SLC4A4,ZNRF3,ATP13A4,SORBS1,SFXN5,NHSL1,PITPNC1,RFX4
1.891e-02	-3.97	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	2	ATP1A2
1.897e-02	-3.96	human chr12p11.23	chromosome location	human chr12p11.23	10	1	26134	50	ITPR2
1.898e-02	-3.96	BMP signaling pathway	biological process	GO:0030509	77	2	18204	50	BMPR1B,NFIA
1.902e-02	-3.96	testis	COSMIC cancer mutations	testis	733	6	16828	49	FGFR3,BMPR1B,PREX2,TNIK,TRPS1,MACF1
1.907e-02	-3.96	S-adenosylmethionine cycle	biological process	GO:0033353	7	1	18204	50	AHCYL2
1.907e-02	-3.96	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	50	RYR3
1.907e-02	-3.96	regulation of cardiac muscle myoblast proliferation	biological process	GO:0110022	7	1	18204	50	MEIS2
1.907e-02	-3.96	glutathione transmembrane transport	biological process	GO:0034775	7	1	18204	50	GJA1
1.907e-02	-3.96	glial cell fate specification	biological process	GO:0021780	7	1	18204	50	NFIA
1.907e-02	-3.96	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	50	PTPRZ1
1.907e-02	-3.96	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	50	CTNNA2
1.907e-02	-3.96	negative regulation of non-canonical Wnt signaling pathway	biological process	GO:2000051	7	1	18204	50	ZNRF3
1.909e-02	-3.96	cell communication	biological process	GO:0007154	5010	21	18204	50	RYR3,GJA1,SLC1A3,PREX2,ZNRF3,SPARCL1,ITPR2,FGFR3,ATP1A2,PARD3,BMPR1B,SORBS1,LIFR,TNIK,MACF1,CTNND2,NFIA,DTNA,PITPNC1,SLC1A2,CPE
1.914e-02	-3.96	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	49	MACF1,FGFR3
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	SORBS1,ATP1A2
1.930e-02	-3.95	TM2D3 (TM2 domain containing 3)	protein interactions	80213	83	2	19454	50	FGFR3,PON2
1.930e-02	-3.95	PAX2 (paired box 2)	protein interactions	5076	83	2	19454	50	TRPS1,NFIA
1.930e-02	-3.95	DNM3 (dynamin 3)	protein interactions	26052	83	2	19454	50	GPM6A,FGFR3
1.939e-02	-3.94	YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)	protein interactions	10971	1076	7	19454	50	ABLIM1,GJA1,PARD3,NHSL1,SORBS1,PARD3B,MACF1
1.943e-02	-3.94	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	MACF1,ITPR2,GPC5,ATP13A4,SLC1A2,PARD3,PREX2
1.943e-02	-3.94	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	PREX2,SLC1A2,PARD3,ATP13A4,ITPR2,GPC5,MACF1
1.944e-02	-3.94	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	50	SORBS1,SLC1A2
1.949e-02	-3.94	Thyroid hormone synthesis	KEGG pathways	ko04918	74	2	7161	21	ATP1A2,ITPR2
1.949e-02	-3.94	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	2	7161	21	ATP1A2,ITPR2
1.951e-02	-3.94	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	50	SPARCL1
1.951e-02	-3.94	TGF_beta_GS	pfam domains	PF08515	7	1	17795	50	BMPR1B
1.954e-02	-3.94	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	48	FGFR3,BMPR1B
1.962e-02	-3.93	UBE2A (ubiquitin conjugating enzyme E2 A)	protein interactions	7319	223	3	19454	50	GJA1,CTNNA2,TNIK
1.964e-02	-3.93	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	49	FGFR3,MACF1
1.974e-02	-3.93	ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)	protein interactions	7903	84	2	19454	50	PON2,LRIG1
1.976e-02	-3.92	FBXO2 (F-box protein 2)	protein interactions	26232	403	4	19454	50	LIFR,LRIG1,NTM,FGFR3
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	GPM6A,ABLIM1,MACF1
1.991e-02	-3.92	apical plasma membrane	cellular component	GO:0016324	405	4	19108	49	PARD3B,PARD3,TNIK,GJA1
1.993e-02	-3.92	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	21	SLC4A4
1.993e-02	-3.92	PITRANSFER	prints domains	PR00391	5	1	5227	21	PITPNC1
1.999e-02	-3.91	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	21	ATP1A2,ITPR2
1.999e-02	-3.91	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	21	ITPR2,ATP1A2
2.002e-02	-3.91	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	7	19454	50	ABLIM1,PITPNC1,SORBS1,NHSL1,PARD3,MACF1,PARD3B
2.003e-02	-3.91	metal ion binding	molecular function	GO:0046872	4239	18	18094	48	CPE,ZBTB20,DTNA,ATP13A4,SPARCL1,TRPS1,SPON1,ABLIM1,ITPR2,GLUL,RYR3,PON2,ATP1A2,SLC1A3,ZNRF3,BMPR1B,MACF1,SLC1A2
2.008e-02	-3.91	KLF3 (KLF transcription factor 3)	protein interactions	51274	225	3	19454	50	TRPS1,NFIA,SOX5
2.021e-02	-3.90	skin-shoulder-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-shoulder-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-face-adnexal_tumour-malignant_adnexal_tumour	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-neck-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-neck-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	urinary_tract-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma-transitional_cell_carcinoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	nevus_sebaceous	COSMIC cancer mutations	nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-adnexal_tumour-trichilemmoma	COSMIC cancer mutations	skin-adnexal_tumour-trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-compound	COSMIC cancer mutations	skin-benign_melanocytic_nevus-compound	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-benign_melanocytic_nevus-intradermal	COSMIC cancer mutations	skin-benign_melanocytic_nevus-intradermal	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-other-nevus_sebaceous	COSMIC cancer mutations	skin-other-nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-chest-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-chest-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	trichilemmoma	COSMIC cancer mutations	trichilemmoma	7	1	16828	49	FGFR3
2.025e-02	-3.90	FGFR3b ligand binding and activation	REACTOME pathways	R-HSA-190371	7	1	10285	30	FGFR3
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	SCT (secretin)	protein interactions	6343	8	1	19454	50	MEIS2
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	DEFB104A (defensin beta 104A)	protein interactions	140596	8	1	19454	50	GJA1
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.038e-02	-3.89	CCK (cholecystokinin)	protein interactions	885	8	1	19454	50	CPE
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.055e-02	-3.88	MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)	protein interactions	9448	227	3	19454	50	GJA1,TNIK,PARD3
2.055e-02	-3.88	receptor complex	cellular component	GO:0043235	409	4	19108	49	ITPR2,BMPR1B,FGFR3,LIFR
2.063e-02	-3.88	FAM171A1 (family with sequence similarity 171 member A1)	protein interactions	221061	86	2	19454	50	PARD3,GJA1
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	SORBS1,GPM6A
2.072e-02	-3.88	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	44	NEBL,ABLIM1
2.076e-02	-3.87	response to nitrogen compound	biological process	GO:1901698	1021	7	18204	50	SORBS1,TNIK,GJA1,RYR3,SLC1A2,SLC1A3,ITPR2
2.087e-02	-3.87	adult locomotory behavior	biological process	GO:0008344	81	2	18204	50	ATP1A2,PREX2
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	MACF1,SPARCL1,RYR3
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.103e-02	-3.86	gap junction channel activity involved in cell communication by electrical coupling	molecular function	GO:1903763	8	1	18094	48	GJA1
2.105e-02	-3.86	glutamatergic synapse	cellular component	GO:0098978	412	4	19108	49	SLC1A2,TNIK,SPARCL1,GPM6A
2.106e-02	-3.86	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	4	16828	49	MACF1,PREX2,CPE,CTNND2
2.106e-02	-3.86	Immunoglobulins	gene3d domains	2.60.40.10	721	6	14470	44	NTM,LSAMP,PTPRZ1,LIFR,LRIG1,FGFR3
2.108e-02	-3.86	Kctd5 (potassium channel tetramerisation domain containing 5)	protein interactions	69259	87	2	19454	50	SLC1A3,TRPS1
2.108e-02	-3.86	ZNF608 (zinc finger protein 608)	protein interactions	57507	87	2	19454	50	NFIA,SOX5
2.108e-02	-3.86	NHLH1 (nescient helix-loop-helix 1)	protein interactions	4807	87	2	19454	50	TRPS1,NFIA
2.123e-02	-3.85	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	46	16828	49	ABLIM1,NPAS3,LSAMP,TNIK,SOX5,NFIA,AQP4,NKAIN3,ATP1A2,GLUL,PARD3,NEBL,SPON1,BMPR1B,FGFR3,PTPRZ1,GJA1,SLC1A2,CTNND2,ZBTB20,MACF1,TRPS1,FBXL7,CPE,SLC1A3,MSI2,LRIG1,GPM6A,GPC5,RYR3,DTNA,PARD3B,PREX2,SPARCL1,AHCYL2,CDH20,LIFR,ITPR2,ATP13A4,MEIS2,ZNRF3,SLC4A4,PITPNC1,NHSL1,SORBS1,SFXN5
2.123e-02	-3.85	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	46	16828	49	BMPR1B,FGFR3,PTPRZ1,SLC1A2,GJA1,CTNND2,ZBTB20,MACF1,PARD3,GLUL,SPON1,NEBL,TNIK,SOX5,LSAMP,AQP4,NKAIN3,ATP1A2,NFIA,ABLIM1,NPAS3,SORBS1,SFXN5,PITPNC1,NHSL1,ATP13A4,MEIS2,SLC4A4,ZNRF3,PREX2,SPARCL1,RYR3,DTNA,PARD3B,AHCYL2,CDH20,ITPR2,LIFR,TRPS1,CPE,SLC1A3,FBXL7,LRIG1,GPC5,GPM6A,MSI2
2.125e-02	-3.85	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	44	ATP13A4,ATP1A2
2.125e-02	-3.85	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	12	16828	49	ATP1A2,NFIA,BMPR1B,PTPRZ1,FGFR3,PREX2,SOX5,TNIK,DTNA,PARD3B,SLC4A4,TRPS1
2.126e-02	-3.85	femur	COSMIC cancer mutations	femur	1197	8	16828	49	RYR3,GLUL,PTPRZ1,PON2,SPON1,GPC5,LRIG1,SLC4A4
2.130e-02	-3.85	leg	COSMIC cancer mutations	leg	969	7	16828	49	NTM,SLC4A4,ZBTB20,NEBL,FGFR3,PTPRZ1,ATP13A4
2.135e-02	-3.85	regulation of bone mineralization	biological process	GO:0030500	82	2	18204	50	BMPR1B,GJA1
2.140e-02	-3.84	Gln_synth/guanido_kin_cat_dom	interpro domains	IPR014746	8	1	18521	50	GLUL
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.147e-02	-3.84	GAR	prosite domains	PS51460	6	1	12186	44	MACF1
2.147e-02	-3.84	GLYPICAN	prosite domains	PS01207	6	1	12186	44	GPC5
2.151e-02	-3.84	SLC15A3 (solute carrier family 15 member 3)	protein interactions	51296	231	3	19454	50	ITPR2,GJA1,PON2
2.153e-02	-3.84	TMEM128 (transmembrane protein 128)	protein interactions	85013	88	2	19454	50	GJA1,SLC1A3
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	TNIK,BMPR1B
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	NTM,LRIG1,LSAMP,FGFR3
2.177e-02	-3.83	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	50	ATP1A2
2.177e-02	-3.83	gap junction assembly	biological process	GO:0016264	8	1	18204	50	GJA1
2.177e-02	-3.83	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	50	CTNNA2
2.177e-02	-3.83	glutamate catabolic process	biological process	GO:0006538	8	1	18204	50	GLUL
2.177e-02	-3.83	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	50	SLC1A3
2.177e-02	-3.83	regulation of ventricular cardiac muscle cell membrane depolarization	biological process	GO:0060373	8	1	18204	50	GJA1
2.177e-02	-3.83	negative regulation of gonadotropin secretion	biological process	GO:0032277	8	1	18204	50	GJA1
2.177e-02	-3.83	insulin processing	biological process	GO:0030070	8	1	18204	50	CPE
2.177e-02	-3.83	negative regulation of trophoblast cell migration	biological process	GO:1901164	8	1	18204	50	GJA1
2.184e-02	-3.82	cardiac muscle contraction	biological process	GO:0060048	83	2	18204	50	ATP1A2,GJA1
2.185e-02	-3.82	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	9	16828	49	SLC4A4,GPC5,SORBS1,LSAMP,RYR3,TNIK,TRPS1,CTNND2,PARD3
2.195e-02	-3.82	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	39	16828	49	MACF1,NHSL1,ZBTB20,SFXN5,SORBS1,CTNND2,GJA1,SLC1A2,FGFR3,BMPR1B,PTPRZ1,NEBL,SLC4A4,ZNRF3,MEIS2,ATP13A4,GLUL,PARD3,ATP1A2,ITPR2,LIFR,CDH20,AHCYL2,PARD3B,LSAMP,RYR3,DTNA,SOX5,TNIK,PREX2,MSI2,GPC5,LRIG1,NTM,FBXL7,SLC1A3,CPE,TRPS1,NPAS3
2.199e-02	-3.82	PLEKHA2 (pleckstrin homology domain containing A2)	protein interactions	59339	89	2	19454	50	DTNA,AHCYL2
2.199e-02	-3.82	SOX10 (SRY-box transcription factor 10)	protein interactions	6663	89	2	19454	50	TRPS1,NFIA
2.203e-02	-3.82	SH3_domain	interpro domains	IPR001452	222	3	18521	50	NEBL,SORBS1,MACF1
2.207e-02	-3.81	Endochondral Ossification	WikiPathways	WP474	65	2	5310	19	SOX5,FGFR3
2.210e-02	-3.81	response to stimulus	biological process	GO:0050896	7803	29	18204	50	CTNNA2,PON2,ZBTB20,TNIK,PITPNC1,NFIA,MEIS2,CPE,GLUL,GPM6A,GJA1,ZNRF3,PREX2,SPARCL1,AQP4,SLC1A3,ATP1A2,FGFR3,PARD3,CTNND2,MACF1,SORBS1,BMPR1B,SOX5,LIFR,DTNA,SLC1A2,RYR3,ITPR2
2.212e-02	-3.81	RHOJ (ras homolog family member J)	protein interactions	57381	628	5	19454	50	MACF1,SLC1A3,BMPR1B,GJA1,PARD3
2.224e-02	-3.81	glial cell differentiation	biological process	GO:0010001	219	3	18204	50	PTPRZ1,PARD3,NFIA
2.224e-02	-3.81	HMG20A (high mobility group 20A)	protein interactions	10363	234	3	19454	50	DTNA,SOX5,NFIA
2.226e-02	-3.80	VHP	pfam domains	PF02209	8	1	17795	50	ABLIM1
2.233e-02	-3.80	L-amino acid transport	biological process	GO:0015807	84	2	18204	50	SLC1A3,SLC1A2
2.233e-02	-3.80	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	50	ATP1A2,NKAIN3
2.244e-02	-3.80	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	30	ATP13A4,ATP1A2,RYR3
2.246e-02	-3.80	STXBP2 (syntaxin binding protein 2)	protein interactions	6813	90	2	19454	50	GLUL,GJA1
2.250e-02	-3.79	response to mechanical stimulus	biological process	GO:0009612	220	3	18204	50	ATP1A2,MEIS2,SLC1A3
2.272e-02	-3.78	human chr11p15.2	chromosome location	human chr11p15.2	12	1	26134	50	SPON1
2.274e-02	-3.78	CREB3 (cAMP responsive element binding protein 3)	protein interactions	10488	236	3	19454	50	AQP4,GJA1,GLUL
2.285e-02	-3.78	astrocyte end-foot	cellular component	GO:0097450	9	1	19108	49	AQP4
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.285e-02	-3.78	platelet dense tubular network membrane	cellular component	GO:0031095	9	1	19108	49	ITPR2
2.285e-02	-3.78	fascia adherens	cellular component	GO:0005916	9	1	19108	49	GJA1
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	FGFR3
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	GUSBP1 (GUSB pseudogene 1)	protein interactions	728411	9	1	19454	50	FGFR3
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	TNIK,SORBS1
2.292e-02	-3.78	FOXI1 (forkhead box I1)	protein interactions	2299	91	2	19454	50	NFIA,TRPS1
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	NTM,GPM6A
2.292e-02	-3.78	TRIO (trio Rho guanine nucleotide exchange factor)	protein interactions	7204	91	2	19454	50	GJA1,PARD3
2.299e-02	-3.77	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	3	19454	50	ITPR2,GPM6A,SOX5
2.306e-02	-3.77	cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	trichoblastoma	COSMIC cancer mutations	trichoblastoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	junctional	COSMIC cancer mutations	junctional	8	1	16828	49	FGFR3
2.306e-02	-3.77	actinic_keratosis	COSMIC cancer mutations	actinic_keratosis	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.306e-02	-3.77	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	8	1	16828	49	FGFR3
2.311e-02	-3.77	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	30	GPC5
2.312e-02	-3.77	STX4 (syntaxin 4)	protein interactions	6810	423	4	19454	50	DTNA,PARD3,LIFR,GJA1
2.318e-02	-3.76	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	3	16828	49	NTM,SLC4A4,ATP13A4
2.324e-02	-3.76	LCOR (ligand dependent nuclear receptor corepressor)	protein interactions	84458	238	3	19454	50	GLUL,SPARCL1,MACF1
2.324e-02	-3.76	GAS2	smart domains	SM00243	6	1	9717	38	MACF1
2.325e-02	-3.76	forearm	COSMIC cancer mutations	forearm	81	2	16828	49	FGFR3,PREX2
2.339e-02	-3.76	GPR12 (G protein-coupled receptor 12)	protein interactions	2835	92	2	19454	50	GJA1,SFXN5
2.339e-02	-3.76	POTEI (POTE ankyrin domain family member I)	protein interactions	653269	92	2	19454	50	FGFR3,DTNA
2.339e-02	-3.76	FNTA (farnesyltransferase, CAAX box, subunit alpha)	protein interactions	2339	92	2	19454	50	TNIK,FGFR3
2.339e-02	-3.76	ADGRG5 (adhesion G protein-coupled receptor G5)	protein interactions	221188	92	2	19454	50	GPM6A,GJA1
2.339e-02	-3.76	SOX9 (SRY-box transcription factor 9)	protein interactions	6662	92	2	19454	50	TRPS1,NFIA
2.346e-02	-3.75	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	7	18204	50	SORBS1,GJA1,ZBTB20,RYR3,SLC1A2,ITPR2,SLC1A3
2.346e-02	-3.75	response to oxygen-containing compound	biological process	GO:1901700	1546	9	18204	50	SLC1A2,ATP1A2,SLC1A3,ITPR2,GJA1,ZBTB20,SORBS1,RYR3,GLUL
2.381e-02	-3.74	collagen-containing extracellular matrix	cellular component	GO:0062023	428	4	19108	49	SPON1,PTPRZ1,SPARCL1,GPC5
2.384e-02	-3.74	associative learning	biological process	GO:0008306	87	2	18204	50	ATP1A2,MEIS2
2.385e-02	-3.74	intermediate filament cytoskeleton	cellular component	GO:0045111	241	3	19108	49	GJA1,DTNA,MACF1
2.387e-02	-3.74	MPDZ (multiple PDZ domain crumbs cell polarity complex component)	protein interactions	8777	93	2	19454	50	FGFR3,PARD3
2.387e-02	-3.74	ODR4 (odr-4 GPCR localization factor homolog)	protein interactions	54953	93	2	19454	50	LRIG1,GPM6A
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	ABLIM1,BMPR1B
2.387e-02	-3.74	PTPRG (protein tyrosine phosphatase receptor type G)	protein interactions	5793	93	2	19454	50	GJA1,PARD3
2.388e-02	-3.73	ACTIVIN2R	prints domains	PR00653	6	1	5227	21	BMPR1B
2.401e-02	-3.73	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	50	PARD3,GJA1,CTNND2
2.401e-02	-3.73	-	gene3d domains	2.80.10.50	79	2	14470	44	ITPR2,RYR3
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.407e-02	-3.73	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	44	ABLIM1
2.435e-02	-3.72	KIAA1217 (KIAA1217)	protein interactions	56243	94	2	19454	50	GJA1,PARD3
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	ABLIM1,TNIK
2.435e-02	-3.72	QSER1 (glutamine and serine rich 1)	protein interactions	79832	94	2	19454	50	SOX5,NFIA
2.435e-02	-3.72	TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1)	protein interactions	85461	94	2	19454	50	GJA1,PARD3
2.435e-02	-3.72	FOXP4 (forkhead box P4)	protein interactions	116113	94	2	19454	50	SOX5,NFIA
2.440e-02	-3.71	cell-cell signaling	biological process	GO:0007267	822	6	18204	50	SLC1A3,DTNA,GJA1,CPE,FGFR3,SLC1A2
2.446e-02	-3.71	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	50	CTNNA2
2.446e-02	-3.71	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	50	CTNNA2
2.446e-02	-3.71	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	50	RYR3
2.446e-02	-3.71	glutathione transport	biological process	GO:0034635	9	1	18204	50	GJA1
2.446e-02	-3.71	tripeptide transmembrane transport	biological process	GO:0035443	9	1	18204	50	GJA1
2.446e-02	-3.71	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	50	ATP1A2
2.446e-02	-3.71	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	50	ATP13A4
2.446e-02	-3.71	regulation of protein localization to nucleolus	biological process	GO:1904749	9	1	18204	50	GLUL
2.459e-02	-3.71	human chr5p15.1	chromosome location	human chr5p15.1	13	1	26134	50	FBXL7
2.468e-02	-3.70	skeletal system morphogenesis	biological process	GO:0048705	228	3	18204	50	FGFR3,BMPR1B,SOX5
2.474e-02	-3.70	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	3	10285	30	GLUL,SLC1A2,SLC1A3
2.483e-02	-3.70	MPP7 (MAGUK p55 scaffold protein 7)	protein interactions	143098	95	2	19454	50	MEIS2,GJA1
2.487e-02	-3.69	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	2	18204	50	SORBS1,ZBTB20
2.495e-02	-3.69	axon	cellular component	GO:0030424	650	5	19108	49	CTNNA2,GPM6A,SLC1A2,PARD3,DTNA
2.501e-02	-3.69	HEMATOPO_REC_L_F2	prosite domains	PS01353	7	1	12186	44	LIFR
2.501e-02	-3.69	GS	prosite domains	PS51256	7	1	12186	44	BMPR1B
2.501e-02	-3.69	Band_3_cyto	pfam domains	PF07565	9	1	17795	50	SLC4A4
2.501e-02	-3.69	Activin_recp	pfam domains	PF01064	9	1	17795	50	BMPR1B
2.501e-02	-3.69	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	50	RFX4
2.505e-02	-3.69	SCRIB (scribble planar cell polarity protein)	protein interactions	23513	245	3	19454	50	GJA1,LRIG1,PARD3
2.521e-02	-3.68	sarcoplasm	cellular component	GO:0016528	96	2	19108	49	ITPR2,RYR3
2.523e-02	-3.68	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	3	16828	49	PON2,DTNA,RFX4
2.523e-02	-3.68	cation binding	molecular function	GO:0043169	4341	18	18094	48	MACF1,SLC1A2,ATP1A2,SLC1A3,ZNRF3,BMPR1B,ITPR2,ABLIM1,RYR3,GLUL,PON2,SPARCL1,TRPS1,SPON1,ZBTB20,DTNA,ATP13A4,CPE
2.528e-02	-3.68	Diseases of glycosylation	REACTOME pathways	R-HSA-3781865	85	2	10285	30	GPC5,SPON1
2.536e-02	-3.67	perineuronal net	cellular component	GO:0072534	10	1	19108	49	PTPRZ1
2.539e-02	-3.67	regulation of purine nucleotide metabolic process	biological process	GO:1900542	90	2	18204	50	SLC4A4,ZBTB20
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	BANK1 (B cell scaffold protein with ankyrin repeats 1)	protein interactions	55024	10	1	19454	50	ITPR2
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	SERPINB11 (serpin family B member 11)	protein interactions	89778	10	1	19454	50	CPE
2.541e-02	-3.67	ALKAL2 (ALK and LTK ligand 2)	protein interactions	285016	10	1	19454	50	PON2
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.541e-02	-3.67	TSHZ1 (teashirt zinc finger homeobox 1)	protein interactions	10194	10	1	19454	50	MEIS2
2.581e-02	-3.66	BTG3 (BTG anti-proliferation factor 3)	protein interactions	10950	97	2	19454	50	GLUL,SPARCL1
2.585e-02	-3.66	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	3	19454	50	SOX5,TNIK,NFIA
2.585e-02	-3.66	MET (MET proto-oncogene, receptor tyrosine kinase)	protein interactions	4233	248	3	19454	50	LRIG1,GJA1,ZNRF3
2.589e-02	-3.65	shoulder	COSMIC cancer mutations	shoulder	387	4	16828	49	FGFR3,PREX2,CPE,MACF1
2.591e-02	-3.65	epidermal_nevus	COSMIC cancer mutations	epidermal_nevus	9	1	16828	49	FGFR3
2.591e-02	-3.65	compound	COSMIC cancer mutations	compound	9	1	16828	49	FGFR3
2.591e-02	-3.65	in_situ_epithelial_neoplasm	COSMIC cancer mutations	in_situ_epithelial_neoplasm	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	skin-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-other-seborrhoeic_keratosis	9	1	16828	49	FGFR3
2.591e-02	-3.65	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	COSMIC cancer mutations	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	Bowen_disease	COSMIC cancer mutations	Bowen_disease	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-benign_melanocytic_nevus-congenital	COSMIC cancer mutations	skin-benign_melanocytic_nevus-congenital	9	1	16828	49	FGFR3
2.592e-02	-3.65	regulation of nucleotide metabolic process	biological process	GO:0006140	91	2	18204	50	SLC4A4,ZBTB20
2.592e-02	-3.65	response to BMP	biological process	GO:0071772	91	2	18204	50	BMPR1B,NFIA
2.592e-02	-3.65	cellular response to BMP stimulus	biological process	GO:0071773	91	2	18204	50	BMPR1B,NFIA
2.595e-02	-3.65	contractile muscle fiber	cellular component	GO:0043292	249	3	19108	49	GJA1,RYR3,NEBL
2.596e-02	-3.65	Synthesis of 5-eicosatetraenoic acids	REACTOME pathways	R-HSA-2142688	9	1	10285	30	PON2
2.596e-02	-3.65	Formation of annular gap junctions	REACTOME pathways	R-HSA-196025	9	1	10285	30	GJA1
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.622e-02	-3.64	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	48	ATP13A4
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	GPM6A,LSAMP
2.637e-02	-3.64	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	50	ATP1A2,FGFR3,ITPR2,PREX2,TNIK,RYR3
2.645e-02	-3.63	protein tetramerization	biological process	GO:0051262	92	2	18204	50	RYR3,AQP4
2.646e-02	-3.63	human chr2p13.2	chromosome location	human chr2p13.2	14	1	26134	50	SFXN5
2.654e-02	-3.63	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	49	SLC4A4,ITPR2,FGFR3,PREX2,PARD3B
2.666e-02	-3.62	TCF7L2 (transcription factor 7 like 2)	protein interactions	6934	251	3	19454	50	NFIA,LIFR,CTNNA2
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIP_CS	interpro domains	IPR022357	10	1	18521	50	AQP4
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.680e-02	-3.62	DEFA1 (defensin alpha 1)	protein interactions	1667	99	2	19454	50	LIFR,LRIG1
2.680e-02	-3.62	ZFHX3 (zinc finger homeobox 3)	protein interactions	463	99	2	19454	50	SOX5,TRPS1
2.683e-02	-3.62	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	48	ATP13A4,ATP1A2
2.693e-02	-3.61	CRX (cone-rod homeobox)	protein interactions	1406	252	3	19454	50	SOX5,TRPS1,NFIA
2.695e-02	-3.61	Gap junction	KEGG pathways	ko04540	88	2	7161	21	ITPR2,GJA1
2.695e-02	-3.61	Gap junction	KEGG pathways	hsa04540	88	2	7161	21	GJA1,ITPR2
2.705e-02	-3.61	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	44	NEBL,ABLIM1
2.705e-02	-3.61	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	44	NEBL,ABLIM1
2.706e-02	-3.61	peritoneum-appendix-other-pseudomyxoma_peritonei	COSMIC cancer mutations	peritoneum-appendix-other-pseudomyxoma_peritonei	585	5	16828	49	TRPS1,FBXL7,FGFR3,MEIS2,MACF1
2.706e-02	-3.61	pseudomyxoma_peritonei	COSMIC cancer mutations	pseudomyxoma_peritonei	585	5	16828	49	MACF1,MEIS2,FGFR3,FBXL7,TRPS1
2.706e-02	-3.61	PLEC	smart domains	SM00250	7	1	9717	38	MACF1
2.706e-02	-3.61	GS	smart domains	SM00467	7	1	9717	38	BMPR1B
2.714e-02	-3.61	neuronal action potential propagation	biological process	GO:0019227	10	1	18204	50	ATP1A2
2.714e-02	-3.61	regulation of mesodermal cell differentiation	biological process	GO:1905770	10	1	18204	50	GJA1
2.714e-02	-3.61	action potential propagation	biological process	GO:0098870	10	1	18204	50	ATP1A2
2.714e-02	-3.61	otolith development	biological process	GO:0048840	10	1	18204	50	LRIG1
2.714e-02	-3.61	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	50	RYR3
2.714e-02	-3.61	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	50	SOX5
2.714e-02	-3.61	regulation of atrial cardiac muscle cell membrane depolarization	biological process	GO:0060371	10	1	18204	50	GJA1
2.723e-02	-3.60	appendix	COSMIC cancer mutations	appendix	586	5	16828	49	FBXL7,TRPS1,MEIS2,FGFR3,MACF1
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	ATP1A2,GPM6A
2.741e-02	-3.60	uveal_tract	COSMIC cancer mutations	uveal_tract	587	5	16828	49	CTNND2,CPE,PREX2,FGFR3,MACF1
2.741e-02	-3.60	peritoneum	COSMIC cancer mutations	peritoneum	587	5	16828	49	MEIS2,FGFR3,FBXL7,TRPS1,MACF1
2.769e-02	-3.59	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	3	16828	49	RFX4,PON2,DTNA
2.775e-02	-3.58	HCO3_cotransp	pfam domains	PF00955	10	1	17795	50	SLC4A4
2.775e-02	-3.58	PAS_3	pfam domains	PF08447	10	1	17795	50	NPAS3
2.776e-02	-3.58	DYNLL2 (dynein light chain LC8-type 2)	protein interactions	140735	255	3	19454	50	NHSL1,TRPS1,NFIA
2.781e-02	-3.58	STAMBP (STAM binding protein)	protein interactions	10617	101	2	19454	50	BMPR1B,GJA1
2.781e-02	-3.58	PRKCG (protein kinase C gamma)	protein interactions	5582	101	2	19454	50	GJA1,PARD3
2.781e-02	-3.58	CPNE8 (copine 8)	protein interactions	144402	101	2	19454	50	PARD3,GJA1
2.781e-02	-3.58	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	50	FGFR3,CTNNA2
2.786e-02	-3.58	platelet dense tubular network	cellular component	GO:0031094	11	1	19108	49	ITPR2
2.786e-02	-3.58	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	49	PTPRZ1
2.792e-02	-3.58	cellular component organization or biogenesis	biological process	GO:0071840	5850	23	18204	50	CTNND2,MACF1,SORBS1,PTPRZ1,BMPR1B,NEBL,PARD3,SLC1A2,ABLIM1,CDH20,RYR3,RFX4,TNIK,CTNNA2,PITPNC1,NFIA,GPM6A,GJA1,PARD3B,GLUL,PREX2,AQP4,SPARCL1
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	ITPR2
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	GAL3ST1 (galactose-3-O-sulfotransferase 1)	protein interactions	9514	11	1	19454	50	LRIG1
2.792e-02	-3.58	NTS (neurotensin)	protein interactions	4922	11	1	19454	50	CPE
2.792e-02	-3.58	CCDC17 (coiled-coil domain containing 17)	protein interactions	149483	11	1	19454	50	FGFR3
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.795e-02	-3.58	axon development	biological process	GO:0061564	420	4	18204	50	BMPR1B,PTPRZ1,PARD3,CTNNA2
2.807e-02	-3.57	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	50	RYR3,ITPR2
2.809e-02	-3.57	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	50	FGFR3,LIFR,SORBS1,BMPR1B,NFIA
2.829e-02	-3.57	Phase I biotransformations, non P450	WikiPathways	WP136	8	1	5310	19	PON2
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.832e-02	-3.56	TMPRSS13 (transmembrane serine protease 13)	protein interactions	84000	102	2	19454	50	SPON1,CPE
2.838e-02	-3.56	response to radiation	biological process	GO:0009314	422	4	18204	50	SLC1A3,MEIS2,ATP1A2,SLC1A2
2.853e-02	-3.56	HP	prosite domains	PS51089	8	1	12186	44	ABLIM1
2.853e-02	-3.56	GATA_ZN_FINGER_1	prosite domains	PS00344	8	1	12186	44	TRPS1
2.872e-02	-3.55	cellular component biogenesis	biological process	GO:0044085	2716	13	18204	50	SLC1A2,ABLIM1,SORBS1,RFX4,NEBL,TNIK,PARD3,AQP4,GPM6A,GJA1,RYR3,CDH20,GLUL
2.875e-02	-3.55	kidney-carcinoma-renal_cell_carcinoma_unclassified	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	renal_cell_carcinoma_unclassified	COSMIC cancer mutations	renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.875e-02	-3.55	cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	lung-carcinoma-pleomorphic_carcinoma	COSMIC cancer mutations	lung-carcinoma-pleomorphic_carcinoma	10	1	16828	49	FGFR3
2.875e-02	-3.55	intradermal	COSMIC cancer mutations	intradermal	10	1	16828	49	FGFR3
2.880e-02	-3.55	Gap junction degradation	REACTOME pathways	R-HSA-190873	10	1	10285	30	GJA1
2.880e-02	-3.55	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	30	FGFR3
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.880e-02	-3.55	oligopeptide transmembrane transporter activity	molecular function	GO:0035673	11	1	18094	48	GJA1
2.881e-02	-3.55	growth	biological process	GO:0040007	424	4	18204	50	FGFR3,GJA1,SLC1A2,BMPR1B
2.881e-02	-3.55	developmental growth	biological process	GO:0048589	424	4	18204	50	GJA1,FGFR3,SLC1A2,BMPR1B
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	GPM6A,BMPR1B
2.884e-02	-3.55	PLEKHA1 (pleckstrin homology domain containing A1)	protein interactions	59338	103	2	19454	50	PARD3,GJA1
2.884e-02	-3.55	ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)	protein interactions	25921	103	2	19454	50	PARD3,GJA1
2.884e-02	-3.55	C1orf94 (chromosome 1 open reading frame 94)	protein interactions	84970	103	2	19454	50	MEIS2,GLUL
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A3,SLC1A2
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	NTM,LSAMP,FGFR3,LRIG1
2.896e-02	-3.54	Methionine degradation	KEGG pathways	hsa_M00035	10	1	7161	21	AHCYL2
2.896e-02	-3.54	Methionine degradation	KEGG pathways	M00035	10	1	7161	21	AHCYL2
2.917e-02	-3.53	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	50	SLC1A2,SLC1A3
2.917e-02	-3.53	nerve development	biological process	GO:0021675	97	2	18204	50	SLC1A3,LRIG1
2.920e-02	-3.53	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	4	19454	50	DTNA,MACF1,CTNND2,PARD3
2.927e-02	-3.53	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	30	NTM,LSAMP
2.946e-02	-3.52	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	3	19454	50	PARD3,DTNA,MACF1
2.954e-02	-3.52	Arrhythmogenic Right Ventricular Cardiomyopathy	WikiPathways	WP2118	76	2	5310	19	CTNNA2,GJA1
2.981e-02	-3.51	polyamine transport	biological process	GO:0015846	11	1	18204	50	ATP13A4
2.981e-02	-3.51	glutamate secretion	biological process	GO:0014047	11	1	18204	50	GJA1
2.981e-02	-3.51	cellular response to caffeine	biological process	GO:0071313	11	1	18204	50	RYR3
2.981e-02	-3.51	tripeptide transport	biological process	GO:0042939	11	1	18204	50	GJA1
2.981e-02	-3.51	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	50	ATP1A2
2.981e-02	-3.51	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	50	ATP1A2
2.981e-02	-3.51	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	50	BMPR1B
2.981e-02	-3.51	lactone metabolic process	biological process	GO:1901334	11	1	18204	50	ATP1A2
2.988e-02	-3.51	BEND3 (BEN domain containing 3)	protein interactions	57673	105	2	19454	50	TRPS1,TNIK
2.988e-02	-3.51	ABCA2 (ATP binding cassette subfamily A member 2)	protein interactions	20	105	2	19454	50	PON2,FGFR3
2.988e-02	-3.51	ANP32E (acidic nuclear phosphoprotein 32 family member E)	protein interactions	81611	105	2	19454	50	AHCYL2,PARD3
3.000e-02	-3.51	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	44	SLC4A4
3.010e-02	-3.50	SH3 Domains	gene3d domains	2.30.30.40	223	3	14470	44	NEBL,MACF1,SORBS1
3.028e-02	-3.50	bone morphogenesis	biological process	GO:0060349	99	2	18204	50	FGFR3,BMPR1B
3.028e-02	-3.50	heart contraction	biological process	GO:0060047	99	2	18204	50	GJA1,ATP1A2
3.030e-02	-3.50	abdomen	COSMIC cancer mutations	abdomen	603	5	16828	49	FGFR3,PREX2,ITPR2,LRIG1,CTNND2
3.034e-02	-3.50	response to wounding	biological process	GO:0009611	431	4	18204	50	NFIA,SLC1A3,SLC1A2,MACF1
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.035e-02	-3.49	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	49	PTPRZ1
3.040e-02	-3.49	PHACTR4 (phosphatase and actin regulator 4)	protein interactions	65979	106	2	19454	50	GJA1,PARD3
3.040e-02	-3.49	USP6NL (USP6 N-terminal like)	protein interactions	9712	106	2	19454	50	GJA1,PARD3
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	UGT1A9 (UDP glucuronosyltransferase family 1 member A9)	protein interactions	54600	12	1	19454	50	PON2
3.042e-02	-3.49	LGR5 (leucine rich repeat containing G protein-coupled receptor 5)	protein interactions	8549	12	1	19454	50	ZNRF3
3.042e-02	-3.49	FAM222A (family with sequence similarity 222 member A)	protein interactions	84915	12	1	19454	50	MEIS2
3.042e-02	-3.49	CTF1 (cardiotrophin 1)	protein interactions	1489	12	1	19454	50	LIFR
3.042e-02	-3.49	IL15 (interleukin 15)	protein interactions	3600	12	1	19454	50	LRIG1
3.042e-02	-3.49	Pard6b (par-6 family cell polarity regulator beta)	protein interactions	58220	12	1	19454	50	PARD3
3.042e-02	-3.49	PROK2 (prokineticin 2)	protein interactions	60675	12	1	19454	50	CPE
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.049e-02	-3.49	LRRCT	pfam domains	PF01463	11	1	17795	50	LRIG1
3.079e-02	-3.48	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	50	ATP1A2,SLC1A3,ATP13A4,RYR3
3.087e-02	-3.48	eye	COSMIC cancer mutations	eye	606	5	16828	49	FGFR3,PREX2,CTNND2,CPE,MACF1
3.087e-02	-3.48	VHP	smart domains	SM00153	8	1	9717	38	ABLIM1
3.093e-02	-3.48	EFR3A (EFR3 homolog A)	protein interactions	23167	107	2	19454	50	GJA1,PARD3
3.093e-02	-3.48	HTR3A (5-hydroxytryptamine receptor 3A)	protein interactions	3359	107	2	19454	50	GPM6A,GJA1
3.093e-02	-3.48	EPHA3 (EPH receptor A3)	protein interactions	2042	107	2	19454	50	PARD3,GJA1
3.093e-02	-3.48	TMEM86B (transmembrane protein 86B)	protein interactions	255043	107	2	19454	50	GJA1,SFXN5
3.107e-02	-3.47	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	4	19454	50	CTNNA2,GJA1,TNIK,PARD3B
3.124e-02	-3.47	LIM	smart domains	SM00132	71	2	9717	38	NEBL,ABLIM1
3.138e-02	-3.46	inositol 1,4,5 trisphosphate binding	molecular function	GO:0070679	12	1	18094	48	ITPR2
3.142e-02	-3.46	positive regulation of cold-induced thermogenesis	biological process	GO:0120162	101	2	18204	50	SFXN5,GJA1
3.147e-02	-3.46	CAMKV (CaM kinase like vesicle associated)	protein interactions	79012	108	2	19454	50	AHCYL2,GPM6A
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	MSI2,RYR3
3.147e-02	-3.46	SLC39A14 (solute carrier family 39 member 14)	protein interactions	23516	108	2	19454	50	GJA1,PARD3
3.147e-02	-3.46	PAX8 (paired box 8)	protein interactions	7849	108	2	19454	50	NFIA,TRPS1
3.151e-02	-3.46	VCL (vinculin)	protein interactions	7414	268	3	19454	50	MACF1,NEBL,SORBS1
3.157e-02	-3.46	calcium ion transport	biological process	GO:0006816	251	3	18204	50	GPM6A,RYR3,ITPR2
3.158e-02	-3.46	skin-neck-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-neck-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.158e-02	-3.46	skin-scalp-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	prostate-hyperplasia	COSMIC cancer mutations	prostate-hyperplasia	11	1	16828	49	FGFR3
3.158e-02	-3.46	seborrhoeic_keratosis	COSMIC cancer mutations	seborrhoeic_keratosis	11	1	16828	49	FGFR3
3.158e-02	-3.46	congenital	COSMIC cancer mutations	congenital	11	1	16828	49	FGFR3
3.158e-02	-3.46	pleomorphic_carcinoma	COSMIC cancer mutations	pleomorphic_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	kidney-other-oncocytoma	COSMIC cancer mutations	kidney-other-oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	oncocytoma	COSMIC cancer mutations	oncocytoma	11	1	16828	49	FGFR3
3.171e-02	-3.45	GATAZNFINGER	prints domains	PR00619	8	1	5227	21	TRPS1
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.193e-02	-3.44	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	37	16828	49	SLC4A4,SPON1,MEIS2,NEBL,PARD3,ATP13A4,SFXN5,MACF1,NHSL1,SLC1A2,CTNND2,RFX4,PTPRZ1,NTM,LRIG1,GPC5,PON2,MSI2,NPAS3,SLC1A3,CPE,FBXL7,ABLIM1,LIFR,ITPR2,ATP1A2,CDH20,AHCYL2,NKAIN3,NFIA,TNIK,SPARCL1,SOX5,PREX2,PARD3B,LSAMP,RYR3
3.193e-02	-3.44	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	37	16828	49	RFX4,PTPRZ1,SLC1A2,CTNND2,SFXN5,NHSL1,MACF1,PARD3,ATP13A4,MEIS2,SLC4A4,SPON1,NEBL,PREX2,TNIK,SPARCL1,SOX5,RYR3,LSAMP,PARD3B,AHCYL2,CDH20,NKAIN3,ITPR2,LIFR,ATP1A2,NFIA,ABLIM1,NPAS3,SLC1A3,CPE,FBXL7,LRIG1,NTM,GPC5,PON2,MSI2
3.200e-02	-3.44	ZNRF4 (zinc and ring finger 4)	protein interactions	148066	109	2	19454	50	PON2,ITPR2
3.204e-02	-3.44	RFX_DBD	prosite domains	PS51526	9	1	12186	44	RFX4
3.230e-02	-3.43	apical part of cell	cellular component	GO:0045177	471	4	19108	49	GJA1,TNIK,PARD3B,PARD3
3.248e-02	-3.43	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	50	BMPR1B
3.248e-02	-3.43	auditory behavior	biological process	GO:0031223	12	1	18204	50	SLC1A3
3.248e-02	-3.43	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	50	BMPR1B
3.248e-02	-3.43	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	50	SLC1A2
3.248e-02	-3.43	oligopeptide transmembrane transport	biological process	GO:0035672	12	1	18204	50	GJA1
3.248e-02	-3.43	regulation of gonadotropin secretion	biological process	GO:0032276	12	1	18204	50	GJA1
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	PARD3B,BMPR1B
3.255e-02	-3.43	cellular component assembly	biological process	GO:0022607	2472	12	18204	50	PARD3,RFX4,SORBS1,TNIK,NEBL,ABLIM1,SLC1A2,RYR3,CDH20,GPM6A,GJA1,AQP4
3.257e-02	-3.42	regulation of biomineral tissue development	biological process	GO:0070167	103	2	18204	50	GJA1,BMPR1B
3.270e-02	-3.42	nervous system process	biological process	GO:0050877	1376	8	18204	50	PTPRZ1,CTNNA2,ATP1A2,LRIG1,MEIS2,SLC1A3,AQP4,ABLIM1
3.291e-02	-3.41	ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5)	protein interactions	8869	13	1	19454	50	PON2
3.291e-02	-3.41	PLPPR4 (phospholipid phosphatase related 4)	protein interactions	9890	13	1	19454	50	ZNRF3
3.291e-02	-3.41	TAS1R3 (taste 1 receptor member 3)	protein interactions	83756	13	1	19454	50	GJA1
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	MAB21L1 (mab-21 like 1)	protein interactions	4081	13	1	19454	50	MEIS2
3.291e-02	-3.41	JAM2 (junctional adhesion molecule 2)	protein interactions	58494	13	1	19454	50	PARD3
3.296e-02	-3.41	Carboxypeptidase-like, regulatory domain	gene3d domains	2.60.40.1120	11	1	14470	44	CPE
3.302e-02	-3.41	endoplasmic reticulum	cellular component	GO:0005783	2051	10	19108	49	GLUL,RYR3,ITPR2,AHCYL2,ATP13A4,FGFR3,SPARCL1,SPON1,ATP1A2,GJA1
3.302e-02	-3.41	FLOT2 (flotillin 2)	protein interactions	2319	273	3	19454	50	SOX5,GJA1,PARD3
3.318e-02	-3.41	protein complex oligomerization	biological process	GO:0051259	256	3	18204	50	SLC1A2,RYR3,AQP4
3.321e-02	-3.40	CarboxypepD_reg	pfam domains	PF13620	12	1	17795	50	CPE
3.321e-02	-3.40	MH1	pfam domains	PF03165	12	1	17795	50	NFIA
3.363e-02	-3.39	CEP170P1 (centrosomal protein 170 pseudogene 1)	protein interactions	645455	112	2	19454	50	MACF1,TRPS1
3.373e-02	-3.39	neural precursor cell proliferation	biological process	GO:0061351	105	2	18204	50	NFIA,SOX5
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.418e-02	-3.38	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	7	19454	50	PITPNC1,NHSL1,PARD3,SORBS1,ABLIM1,PARD3B,MACF1
3.418e-02	-3.38	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	11	16828	49	ATP1A2,SLC4A4,NFIA,SOX5,TRPS1,TNIK,BMPR1B,FGFR3,PTPRZ1,PREX2,DTNA
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	DTNA,ZNRF3
3.418e-02	-3.38	KIRREL1 (kirre like nephrin family adhesion molecule 1)	protein interactions	55243	113	2	19454	50	PARD3,GJA1
3.425e-02	-3.37	signal transduction	biological process	GO:0007165	4637	19	18204	50	RYR3,GJA1,SPARCL1,ITPR2,PREX2,ZNRF3,FGFR3,ATP1A2,PARD3,TNIK,LIFR,BMPR1B,SORBS1,CTNND2,MACF1,NFIA,DTNA,PITPNC1,CPE
3.425e-02	-3.37	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	50	NEBL,GPM6A,SLC1A3
3.439e-02	-3.37	ear	COSMIC cancer mutations	ear	624	5	16828	49	ZBTB20,FGFR3,SPARCL1,LIFR,NPAS3
3.440e-02	-3.37	skin-face-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-basal_cell_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.440e-02	-3.37	cervix-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	cervix-carcinoma-mixed_adenosquamous_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-benign_melanocytic_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus	12	1	16828	49	FGFR3
3.446e-02	-3.37	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	30	GPC5
3.446e-02	-3.37	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	30	GPC5
3.446e-02	-3.37	FGFR3 mutant receptor activation	REACTOME pathways	R-HSA-2033514	12	1	10285	30	FGFR3
3.446e-02	-3.37	Signaling by activated point mutants of FGFR3	REACTOME pathways	R-HSA-1839130	12	1	10285	30	FGFR3
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	SORBS1,ATP1A2
3.466e-02	-3.36	FOLN	smart domains	SM00274	9	1	9717	38	SPARCL1
3.474e-02	-3.36	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	50	MACF1,ZBTB20
3.496e-02	-3.35	response to organic substance	biological process	GO:0010033	2498	12	18204	50	ZBTB20,TNIK,LIFR,SORBS1,SLC1A2,GLUL,RYR3,GJA1,ITPR2,AQP4,SLC1A3,ATP1A2
3.500e-02	-3.35	Ion_trans_dom	interpro domains	IPR005821	109	2	18521	50	ITPR2,RYR3
3.505e-02	-3.35	cellular response to stimulus	biological process	GO:0051716	6307	24	18204	50	GLUL,GJA1,SLC1A3,ZNRF3,PREX2,AQP4,SPARCL1,FGFR3,ATP1A2,ZBTB20,TNIK,NFIA,PITPNC1,CPE,RYR3,ITPR2,PARD3,SORBS1,BMPR1B,LIFR,MACF1,CTNND2,DTNA,SLC1A2
3.514e-02	-3.35	glial cell fate commitment	biological process	GO:0021781	13	1	18204	50	NFIA
3.514e-02	-3.35	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	50	ATP1A2
3.514e-02	-3.35	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	50	ATP1A2
3.514e-02	-3.35	prepulse inhibition	biological process	GO:0060134	13	1	18204	50	CTNNA2
3.529e-02	-3.34	cellular component organization	biological process	GO:0016043	5636	22	18204	50	PARD3B,GPM6A,GJA1,PREX2,AQP4,SPARCL1,CTNNA2,RFX4,TNIK,PITPNC1,NFIA,CDH20,RYR3,PARD3,CTNND2,MACF1,PTPRZ1,SORBS1,BMPR1B,NEBL,ABLIM1,SLC1A2
3.530e-02	-3.34	DTNA (dystrobrevin alpha)	protein interactions	1837	115	2	19454	50	GJA1,PARD3
3.530e-02	-3.34	CDH2 (cadherin 2)	protein interactions	1000	115	2	19454	50	CTNND2,PARD3
3.530e-02	-3.34	SULF2 (sulfatase 2)	protein interactions	55959	115	2	19454	50	PON2,SPON1
3.530e-02	-3.34	PLEKHA7 (pleckstrin homology domain containing A7)	protein interactions	144100	115	2	19454	50	PARD3,GJA1
3.530e-02	-3.34	TBXT (T-box transcription factor T)	protein interactions	6862	115	2	19454	50	NFIA,TRPS1
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	ZBTB20
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	ZNRF3
3.540e-02	-3.34	PLXNA4 (plexin A4)	protein interactions	91584	14	1	19454	50	GPM6A
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	KRTAP22-1 (keratin associated protein 22-1)	protein interactions	337979	14	1	19454	50	MEIS2
3.540e-02	-3.34	FGF7 (fibroblast growth factor 7)	protein interactions	2252	14	1	19454	50	FGFR3
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	VSX2 (visual system homeobox 2)	protein interactions	338917	14	1	19454	50	AHCYL2
3.545e-02	-3.34	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	3	16828	49	GPC5,NPAS3,NFIA
3.545e-02	-3.34	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	3	16828	49	NPAS3,GPC5,NFIA
3.553e-02	-3.34	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	48	16828	49	NPAS3,ABLIM1,NTM,SOX5,TNIK,LSAMP,ATP1A2,NKAIN3,AQP4,NFIA,PARD3,GLUL,SPON1,NEBL,CTNND2,SLC1A2,GJA1,FGFR3,PTPRZ1,BMPR1B,MACF1,ZBTB20,FBXL7,SLC1A3,CPE,TRPS1,GPC5,GPM6A,LRIG1,MSI2,SPARCL1,PREX2,PARD3B,RYR3,DTNA,ITPR2,LIFR,CDH20,AHCYL2,ATP13A4,ZNRF3,SLC4A4,MEIS2,RFX4,SFXN5,SORBS1,PITPNC1,NHSL1
3.554e-02	-3.34	MIP	prosite domains	PS00221	10	1	12186	44	AQP4
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.575e-02	-3.33	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	49	LRIG1,LIFR,FGFR3,BMPR1B,PTPRZ1,TNIK
3.575e-02	-3.33	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	49	PTPRZ1,FGFR3,BMPR1B,TNIK,LIFR,LRIG1
3.576e-02	-3.33	LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)	protein interactions	55004	714	5	19454	50	SLC1A3,DTNA,PARD3,TNIK,GJA1
3.581e-02	-3.33	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	3	16828	49	FGFR3,PTPRZ1,MACF1
3.590e-02	-3.33	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	44	CTNNA2
3.592e-02	-3.33	PRKACA (protein kinase cAMP-activated catalytic subunit alpha)	protein interactions	5566	486	4	19454	50	TNIK,ITPR2,PARD3,SLC4A4
3.610e-02	-3.32	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	16	16828	49	ATP1A2,LIFR,ZBTB20,MACF1,PTPRZ1,PREX2,CTNND2,RYR3,PARD3B,MEIS2,GPC5,SPON1,SLC4A4,LRIG1,PARD3,NPAS3
3.612e-02	-3.32	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	25	16828	49	PREX2,SOX5,RYR3,PARD3B,AHCYL2,CDH20,AQP4,ITPR2,NPAS3,TRPS1,CPE,GPC5,PON2,PTPRZ1,GJA1,CTNND2,SORBS1,ZBTB20,MACF1,PARD3,ATP13A4,MEIS2,ZNRF3,SPON1,NEBL
3.620e-02	-3.32	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	50	ZNRF3,GPC5,CTNND2
3.642e-02	-3.31	ELK3 (ETS transcription factor ELK3)	protein interactions	2004	117	2	19454	50	TRPS1,NFIA
3.642e-02	-3.31	ZMYND19 (zinc finger MYND-type containing 19)	protein interactions	116225	117	2	19454	50	SPON1,CTNND2
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.699e-02	-3.30	SIPA1L2 (signal induced proliferation associated 1 like 2)	protein interactions	57568	118	2	19454	50	PARD3,GJA1
3.699e-02	-3.30	PLCD3 (phospholipase C delta 3)	protein interactions	113026	118	2	19454	50	TNIK,AHCYL2
3.715e-02	-3.29	MIP	interpro domains	IPR000425	14	1	18521	50	AQP4
3.715e-02	-3.29	Aquaporin-like	interpro domains	IPR023271	14	1	18521	50	AQP4
3.721e-02	-3.29	skin-back-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-back-carcinoma-basal_cell_carcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	Brenner_tumour	COSMIC cancer mutations	Brenner_tumour	13	1	16828	49	FGFR3
3.721e-02	-3.29	endometrium-ovary-endometriosis	COSMIC cancer mutations	endometrium-ovary-endometriosis	13	1	16828	49	FGFR3
3.721e-02	-3.29	cervix-carcinoma-adenocarcinoma	COSMIC cancer mutations	cervix-carcinoma-adenocarcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.728e-02	-3.29	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	30	ITPR2
3.728e-02	-3.29	Passive transport by Aquaporins	REACTOME pathways	R-HSA-432047	13	1	10285	30	AQP4
3.728e-02	-3.29	FGFR3c ligand binding and activation	REACTOME pathways	R-HSA-190372	13	1	10285	30	FGFR3
3.728e-02	-3.29	FGFR3 ligand binding and activation	REACTOME pathways	R-HSA-190239	13	1	10285	30	FGFR3
3.728e-02	-3.29	Phospholipase C-mediated cascade; FGFR3	REACTOME pathways	R-HSA-5654227	13	1	10285	30	FGFR3
3.745e-02	-3.28	DHFR2 (dihydrofolate reductase 2)	protein interactions	200895	287	3	19454	50	SLC1A3,CPE,ITPR2
3.750e-02	-3.28	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	2	16828	49	GPC5,PARD3
3.754e-02	-3.28	basal plasma membrane	cellular component	GO:0009925	288	3	19108	49	AQP4,SLC1A3,SLC4A4
3.756e-02	-3.28	ANKRD26 (ankyrin repeat domain containing 26)	protein interactions	22852	119	2	19454	50	PARD3,GJA1
3.764e-02	-3.28	Ion_trans	pfam domains	PF00520	109	2	17795	50	RYR3,ITPR2
3.764e-02	-3.28	Carfentanil Action Pathway	SMPDB pathways	SMP0000414	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Remifentanil Action Pathway	SMPDB pathways	SMP0000416	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Pentazocine Action Pathway	SMPDB pathways	SMP0000686	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Buprenorphine Action Pathway	SMPDB pathways	SMP0000684	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Alvimopan Action Pathway	SMPDB pathways	SMP0000685	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Levomethadyl Acetate Action Action Pathway	SMPDB pathways	SMP0000677	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Methadyl Acetate Action Pathway	SMPDB pathways	SMP0000678	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Fentanyl Action Pathway	SMPDB pathways	SMP0000415	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Ketobemidone Action Pathway	SMPDB pathways	SMP0000690	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Dimethylthiambutene Action Pathway	SMPDB pathways	SMP0000680	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Procaine Action Pathway	SMPDB pathways	SMP0000402	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Hydromorphone Action Pathway	SMPDB pathways	SMP0000410	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Oxycodone Action Pathway	SMPDB pathways	SMP0000409	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Proparacaine Action Pathway	SMPDB pathways	SMP0000403	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Anileridine Action Pathway	SMPDB pathways	SMP0000674	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Dezocine Action Pathway	SMPDB pathways	SMP0000676	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Benzocaine Action Pathway	SMPDB pathways	SMP0000392	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Prilocaine Action Pathway	SMPDB pathways	SMP0000401	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Naltrexone Action Pathway	SMPDB pathways	SMP0000687	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Bupivacaine Action Pathway	SMPDB pathways	SMP0000393	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Mepivacaine Action Pathway	SMPDB pathways	SMP0000399	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Naloxone Action Pathway	SMPDB pathways	SMP0000688	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Diphenoxylate Action Pathway	SMPDB pathways	SMP0000675	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Sufentanil Action Pathway	SMPDB pathways	SMP0000417	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Alfentanil Action Pathway	SMPDB pathways	SMP0000413	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Levallorphan Action Pathway	SMPDB pathways	SMP0000683	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Levobupivacaine Action Pathway	SMPDB pathways	SMP0000397	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Dihydromorphine Action Pathway	SMPDB pathways	SMP0000689	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Oxybuprocaine Action Pathway	SMPDB pathways	SMP0000400	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Oxymorphone Action Pathway	SMPDB pathways	SMP0000412	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Hydrocodone Action Pathway	SMPDB pathways	SMP0000411	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Ethylmorphine Action Pathway	SMPDB pathways	SMP0000681	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Escitalopram Action Pathway	SMPDB pathways	SMP0000425	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Tramadol Action Action Pathway	SMPDB pathways	SMP0000671	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Ropivacaine Action Pathway	SMPDB pathways	SMP0000404	26	1	1369	2	ATP1A2
3.764e-02	-3.28	3-Methylthiofentanyl Action Pathway	SMPDB pathways	SMP0000679	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Levorphanol Action Pathway	SMPDB pathways	SMP0000673	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Cocaine Action Pathway	SMPDB pathways	SMP0000395	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Chloroprocaine Action Pathway	SMPDB pathways	SMP0000394	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Propoxyphene Action Pathway	SMPDB pathways	SMP0000672	26	1	1369	2	ATP1A2
3.764e-02	-3.28	Dibucaine Action Pathway	SMPDB pathways	SMP0000396	26	1	1369	2	ATP1A2
3.771e-02	-3.28	protein localization to membrane	biological process	GO:0072657	462	4	18204	50	PARD3,CPE,TNIK,MACF1
3.779e-02	-3.28	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	50	ATP1A2
3.779e-02	-3.28	atrial cardiac muscle cell to AV node cell signaling	biological process	GO:0086026	14	1	18204	50	GJA1
3.779e-02	-3.28	oligopeptide transport	biological process	GO:0006857	14	1	18204	50	GJA1
3.779e-02	-3.28	cellular response to ethanol	biological process	GO:0071361	14	1	18204	50	ITPR2
3.779e-02	-3.28	adult heart development	biological process	GO:0007512	14	1	18204	50	GJA1
3.779e-02	-3.28	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	50	ATP1A2
3.779e-02	-3.28	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	50	RYR3
3.779e-02	-3.28	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	50	SLC1A2
3.779e-02	-3.28	mechanosensory behavior	biological process	GO:0007638	14	1	18204	50	SLC1A3
3.779e-02	-3.28	atrial cardiac muscle cell action potential	biological process	GO:0086014	14	1	18204	50	GJA1
3.779e-02	-3.28	positive regulation of myoblast proliferation	biological process	GO:2000288	14	1	18204	50	MEIS2
3.779e-02	-3.28	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	50	AQP4
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	FGF9 (fibroblast growth factor 9)	protein interactions	2254	15	1	19454	50	FGFR3
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CPE
3.788e-02	-3.27	TESPA1 (thymocyte expressed, positive selection associated 1)	protein interactions	9840	15	1	19454	50	ITPR2
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	NEBL,SORBS1,ABLIM1
3.814e-02	-3.27	LRP6 (LDL receptor related protein 6)	protein interactions	4040	120	2	19454	50	GJA1,ZNRF3
3.814e-02	-3.27	HOXB9 (homeobox B9)	protein interactions	3219	120	2	19454	50	NFIA,AHCYL2
3.840e-02	-3.26	KIF14 (kinesin family member 14)	protein interactions	9928	1803	9	19454	50	SOX5,SLC1A3,MACF1,NEBL,ITPR2,MSI2,ABLIM1,PARD3,SORBS1
3.843e-02	-3.26	SREBF2 (sterol regulatory element binding transcription factor 2)	protein interactions	6721	290	3	19454	50	GLUL,ABLIM1,SLC4A4
3.856e-02	-3.26	heart process	biological process	GO:0003015	113	2	18204	50	ATP1A2,GJA1
3.864e-02	-3.25	MIP	pfam domains	PF00230	14	1	17795	50	AQP4
3.864e-02	-3.25	GATA	pfam domains	PF00320	14	1	17795	50	TRPS1
3.881e-02	-3.25	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	2	16828	49	PARD3B,NEBL
3.887e-02	-3.25	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	9	18204	50	PARD3,SFXN5,MACF1,BMPR1B,PTPRZ1,SOX5,ZBTB20,GJA1,ATP1A2
3.900e-02	-3.24	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	6	16828	49	MACF1,TRPS1,TNIK,FGFR3,PREX2,BMPR1B
3.902e-02	-3.24	GATA_ZN_FINGER_2	prosite domains	PS50114	11	1	12186	44	TRPS1
3.907e-02	-3.24	Desipramine Action Pathway	SMPDB pathways	SMP0000423	27	1	1369	2	ATP1A2
3.907e-02	-3.24	Nalbuphine Action Pathway	SMPDB pathways	SMP0000691	27	1	1369	2	ATP1A2
3.908e-02	-3.24	neurexin family protein binding	molecular function	GO:0042043	15	1	18094	48	CPE
3.908e-02	-3.24	tropomyosin binding	molecular function	GO:0005523	15	1	18094	48	NEBL
3.908e-02	-3.24	filamin binding	molecular function	GO:0031005	15	1	18094	48	NEBL
3.908e-02	-3.24	efflux transmembrane transporter activity	molecular function	GO:0015562	15	1	18094	48	GJA1
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.914e-02	-3.24	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	49	SLC4A4,PTPRZ1,ATP13A4
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	NHSL1,DTNA
3.941e-02	-3.23	SQSTM1 (sequestosome 1)	protein interactions	8878	984	6	19454	50	PARD3,MEIS2,GJA1,BMPR1B,FGFR3,ABLIM1
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.943e-02	-3.23	human chr4q32.3	chromosome location	human chr4q32.3	21	1	26134	50	CPE
3.947e-02	-3.23	pleura-pulmonary_blastoma	COSMIC cancer mutations	pleura-pulmonary_blastoma	648	5	16828	49	BMPR1B,NTM,TRPS1,NEBL,ATP13A4
3.947e-02	-3.23	pulmonary_blastoma	COSMIC cancer mutations	pulmonary_blastoma	648	5	16828	49	NTM,TRPS1,BMPR1B,ATP13A4,NEBL
3.947e-02	-3.23	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	5	16828	49	PREX2,FGFR3,BMPR1B,TRPS1,TNIK
3.949e-02	-3.23	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	21	SLC4A4
3.970e-02	-3.23	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	5	16828	49	TNIK,FGFR3,ABLIM1,PREX2,MACF1
3.971e-02	-3.23	gliogenesis	biological process	GO:0042063	275	3	18204	50	PTPRZ1,NFIA,PARD3
3.975e-02	-3.23	Znf_GATA	interpro domains	IPR000679	15	1	18521	50	TRPS1
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.988e-02	-3.22	PAX7 (paired box 7)	protein interactions	5081	123	2	19454	50	NFIA,TRPS1
4.002e-02	-3.22	endometriosis	COSMIC cancer mutations	endometriosis	14	1	16828	49	FGFR3
4.002e-02	-3.22	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	14	1	16828	49	FGFR3
4.002e-02	-3.22	soft_tissue-small_round_cell_tumour	COSMIC cancer mutations	soft_tissue-small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	small_round_cell_tumour	COSMIC cancer mutations	small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	in_situ_neoplasm	COSMIC cancer mutations	in_situ_neoplasm	14	1	16828	49	FGFR3
4.008e-02	-3.22	learning or memory	biological process	GO:0007611	276	3	18204	50	MEIS2,ATP1A2,PTPRZ1
4.008e-02	-3.22	telencephalon development	biological process	GO:0021537	276	3	18204	50	RFX4,SLC1A2,ATP1A2
4.010e-02	-3.22	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	30	ABLIM1
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.028e-02	-3.21	phospholipid binding	molecular function	GO:0005543	489	4	18094	48	PITPNC1,ITPR2,PARD3,PARD3B
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	ZNRF3
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	Sumo3 (small ubiquitin-like modifier 3)	protein interactions	20610	16	1	19454	50	ITPR2
4.035e-02	-3.21	HLA-H (major histocompatibility complex, class I, H (pseudogene))	protein interactions	3136	16	1	19454	50	FGFR3
4.035e-02	-3.21	CTSK (cathepsin K)	protein interactions	1513	16	1	19454	50	FGFR3
4.035e-02	-3.21	VGLL1 (vestigial like family member 1)	protein interactions	51442	16	1	19454	50	MEIS2
4.035e-02	-3.21	NBL1 (NBL1, DAN family BMP antagonist)	protein interactions	4681	16	1	19454	50	LRIG1
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	CNTFR (ciliary neurotrophic factor receptor)	protein interactions	1271	16	1	19454	50	LIFR
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.043e-02	-3.21	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	50	ATP1A2
4.043e-02	-3.21	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	50	SORBS1
4.043e-02	-3.21	protein homotrimerization	biological process	GO:0070207	15	1	18204	50	SLC1A2
4.043e-02	-3.21	synapse maturation	biological process	GO:0060074	15	1	18204	50	NFIA
4.043e-02	-3.21	chondrocyte proliferation	biological process	GO:0035988	15	1	18204	50	FGFR3
4.043e-02	-3.21	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	50	RYR3
4.043e-02	-3.21	response to caffeine	biological process	GO:0031000	15	1	18204	50	RYR3
4.043e-02	-3.21	exit from mitosis	biological process	GO:0010458	15	1	18204	50	NFIA
4.043e-02	-3.21	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	50	ATP1A2
4.043e-02	-3.21	columnar/cuboidal epithelial cell maturation	biological process	GO:0002069	15	1	18204	50	GJA1
4.043e-02	-3.21	atrial cardiac muscle cell to AV node cell communication	biological process	GO:0086066	15	1	18204	50	GJA1
4.043e-02	-3.21	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	50	MACF1
4.043e-02	-3.21	neuroblast division	biological process	GO:0055057	15	1	18204	50	SOX5
4.050e-02	-3.21	Lidocaine (Local Anaesthetic) Action Pathway	SMPDB pathways	SMP0000398	28	1	1369	2	ATP1A2
4.069e-02	-3.20	LZTS2 (leucine zipper tumor suppressor 2)	protein interactions	84445	506	4	19454	50	PARD3,SORBS1,GJA1,NEBL
4.079e-02	-3.20	SP7 (Sp7 transcription factor)	protein interactions	121340	297	3	19454	50	NFIA,TRPS1,SOX5
4.094e-02	-3.20	RHOU (ras homolog family member U)	protein interactions	58480	507	4	19454	50	MACF1,AHCYL2,PARD3,GJA1
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	NTM,LRIG1,LSAMP,FGFR3
4.106e-02	-3.19	SLAMF1 (signaling lymphocytic activation molecule family member 1)	protein interactions	6504	125	2	19454	50	CPE,LIFR
4.106e-02	-3.19	SCGB1D1 (secretoglobin family 1D member 1)	protein interactions	10648	125	2	19454	50	CPE,LIFR
4.106e-02	-3.19	STXBP1 (syntaxin binding protein 1)	protein interactions	6812	125	2	19454	50	GJA1,GPM6A
4.106e-02	-3.19	UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats)	protein interactions	55075	125	2	19454	50	PARD3,GJA1
4.106e-02	-3.19	TCHP (trichoplein keratin filament binding)	protein interactions	84260	125	2	19454	50	GLUL,PARD3
4.117e-02	-3.19	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	48	SLC1A2,SLC1A3,SLC4A4
4.121e-02	-3.19	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	14	16828	49	MACF1,LIFR,ATP1A2,BMPR1B,FGFR3,SPARCL1,PON2,MSI2,NEBL,MEIS2,NTM,SLC4A4,NPAS3,PARD3
4.121e-02	-3.19	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	14	16828	49	PARD3,NPAS3,MEIS2,SLC4A4,NTM,MSI2,PON2,NEBL,FGFR3,BMPR1B,SPARCL1,ATP1A2,LIFR,MACF1
4.131e-02	-3.19	extremity	COSMIC cancer mutations	extremity	1876	10	16828	49	RYR3,ATP13A4,FGFR3,PREX2,PTPRZ1,PARD3,FBXL7,PITPNC1,NEBL,CDH20
4.134e-02	-3.19	CNH	pfam domains	PF00780	15	1	17795	50	TNIK
4.134e-02	-3.19	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	50	ATP1A2
4.148e-02	-3.18	bicellular tight junction	cellular component	GO:0005923	126	2	19108	49	PARD3B,PARD3
4.163e-02	-3.18	water channel activity	molecular function	GO:0015250	16	1	18094	48	AQP4
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.166e-02	-3.18	HTR2C (5-hydroxytryptamine receptor 2C)	protein interactions	3358	126	2	19454	50	SFXN5,GJA1
4.171e-02	-3.18	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	7	16828	49	ATP13A4,RYR3,SOX5,PARD3,SLC1A2,GPC5,CDH20
4.176e-02	-3.18	Glycerol uptake facilitator protein	gene3d domains	1.20.1080.10	14	1	14470	44	AQP4
4.193e-02	-3.17	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	50	TNIK,LIFR,SORBS1,BMPR1B,CTNND2,MACF1,FGFR3,CPE,NFIA,ZNRF3
4.193e-02	-3.17	Codeine Action Pathway	SMPDB pathways	SMP0000405	29	1	1369	2	ATP1A2
4.215e-02	-3.17	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	19	BMPR1B
4.215e-02	-3.17	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	19	RYR3
4.225e-02	-3.16	EF_HAND_2	prosite domains	PS50222	215	3	12186	44	SPARCL1,RYR3,MACF1
4.226e-02	-3.16	PAX9 (paired box 9)	protein interactions	5083	127	2	19454	50	TRPS1,NFIA
4.235e-02	-3.16	CarboxyPept-like_regulatory	interpro domains	IPR008969	16	1	18521	50	CPE
4.250e-02	-3.16	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	8	16828	49	CTNND2,CPE,ATP13A4,PARD3B,RYR3,ATP1A2,ITPR2,MACF1
4.282e-02	-3.15	ureter	COSMIC cancer mutations	ureter	15	1	16828	49	FGFR3
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	FLRT3 (fibronectin leucine rich transmembrane protein 3)	protein interactions	23767	17	1	19454	50	GJA1
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	DENND5B (DENN domain containing 5B)	protein interactions	160518	17	1	19454	50	GJA1
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.286e-02	-3.15	FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1)	protein interactions	10160	128	2	19454	50	PARD3,GJA1
4.286e-02	-3.15	TEAD2 (TEA domain transcription factor 2)	protein interactions	8463	128	2	19454	50	TRPS1,ZBTB20
4.286e-02	-3.15	ATG5 (autophagy related 5)	protein interactions	9474	128	2	19454	50	GJA1,FGFR3
4.286e-02	-3.15	MYB (MYB proto-oncogene, transcription factor)	protein interactions	4602	128	2	19454	50	NFIA,TRPS1
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.286e-02	-3.15	SH3BP4 (SH3 domain binding protein 4)	protein interactions	23677	128	2	19454	50	PARD3,GJA1
4.304e-02	-3.15	SH3DOMAIN	prints domains	PR00452	83	2	5227	21	NEBL,SORBS1
4.307e-02	-3.14	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	50	ATP1A2
4.307e-02	-3.14	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	50	ATP1A2
4.307e-02	-3.14	insulin metabolic process	biological process	GO:1901142	16	1	18204	50	CPE
4.307e-02	-3.14	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	50	ATP1A2
4.307e-02	-3.14	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	50	ATP1A2
4.307e-02	-3.14	S-adenosylmethionine metabolic process	biological process	GO:0046500	16	1	18204	50	AHCYL2
4.307e-02	-3.14	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	50	SLC1A2
4.307e-02	-3.14	cardiac left ventricle morphogenesis	biological process	GO:0003214	16	1	18204	50	CPE
4.307e-02	-3.14	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	50	SLC1A3
4.307e-02	-3.14	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	50	ZNRF3
4.307e-02	-3.14	glutamine family amino acid biosynthetic process	biological process	GO:0009084	16	1	18204	50	GLUL
4.321e-02	-3.14	C3orf52 (chromosome 3 open reading frame 52)	protein interactions	79669	304	3	19454	50	GJA1,ITPR2,ZNRF3
4.334e-02	-3.14	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	5	16828	49	SPARCL1,LIFR,TNIK,FGFR3,BMPR1B
4.336e-02	-3.14	Imipramine Action Pathway	SMPDB pathways	SMP0000422	30	1	1369	2	ATP1A2
4.346e-02	-3.14	SLC38A2 (solute carrier family 38 member 2)	protein interactions	54407	129	2	19454	50	GJA1,PARD3
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	ZBTB20,SOX5
4.346e-02	-3.14	POLA2 (DNA polymerase alpha 2, accessory subunit)	protein interactions	23649	129	2	19454	50	CPE,FGFR3
4.352e-02	-3.13	homeostatic process	biological process	GO:0042592	1456	8	18204	50	SLC1A3,ATP13A4,AQP4,ATP1A2,RYR3,ZBTB20,GJA1,SLC4A4
4.377e-02	-3.13	developmental maturation	biological process	GO:0021700	286	3	18204	50	NFIA,GJA1,FGFR3
4.379e-02	-3.13	export from cell	biological process	GO:0140352	485	4	18204	50	CPE,GJA1,SLC4A4,ATP1A2
4.388e-02	-3.13	Z disc	cellular component	GO:0030018	130	2	19108	49	RYR3,NEBL
4.400e-02	-3.12	basal part of cell	cellular component	GO:0045178	307	3	19108	49	AQP4,SLC4A4,SLC1A3
4.415e-02	-3.12	ossification	biological process	GO:0001503	287	3	18204	50	FGFR3,GJA1,BMPR1B
4.417e-02	-3.12	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	48	PTPRZ1
4.417e-02	-3.12	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	48	PTPRZ1
4.428e-02	-3.12	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	5	16828	49	SPARCL1,LIFR,TNIK,FGFR3,BMPR1B
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	SOX5,NFIA
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	SOX5,NFIA
4.479e-02	-3.11	Fluoxetine Action Pathway	SMPDB pathways	SMP0000426	31	1	1369	2	ATP1A2
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	LRIG1,GPM6A,GPC5,MSI2,TRPS1,FBXL7,SLC1A3,CPE,CDH20,AHCYL2,ITPR2,LIFR,PREX2,SPARCL1,RYR3,DTNA,PARD3B,MEIS2,SLC4A4,ZNRF3,ATP13A4,SORBS1,SFXN5,PITPNC1,NHSL1,RFX4,NTM,PON2,ABLIM1,NPAS3,AQP4,NKAIN3,ATP1A2,NFIA,TNIK,SOX5,LSAMP,SPON1,NEBL,PARD3,GLUL,ZBTB20,MACF1,BMPR1B,FGFR3,PTPRZ1,GJA1,SLC1A2,CTNND2
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	SHISA2 (shisa family member 2)	protein interactions	387914	18	1	19454	50	GJA1
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.530e-02	-3.09	PHLDB2 (pleckstrin homology like domain family B member 2)	protein interactions	90102	132	2	19454	50	GJA1,PARD3
4.530e-02	-3.09	GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1)	protein interactions	338328	132	2	19454	50	CPE,FGFR3
4.557e-02	-3.09	cytoskeletal protein binding	molecular function	GO:0008092	989	6	18094	48	ABLIM1,NEBL,SORBS1,CTNNA2,MACF1,GJA1
4.558e-02	-3.09	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	1	5310	19	RYR3
4.560e-02	-3.09	action potential	biological process	GO:0001508	124	2	18204	50	ATP1A2,GJA1
4.560e-02	-3.09	positive regulation of lipid metabolic process	biological process	GO:0045834	124	2	18204	50	SORBS1,ZBTB20
4.560e-02	-3.09	regulation of ossification	biological process	GO:0030278	124	2	18204	50	BMPR1B,GJA1
4.561e-02	-3.09	normal	COSMIC cancer mutations	normal	16	1	16828	49	FGFR3
4.561e-02	-3.09	renal_pelvis	COSMIC cancer mutations	renal_pelvis	16	1	16828	49	FGFR3
4.561e-02	-3.09	flank	COSMIC cancer mutations	flank	16	1	16828	49	FGFR3
4.561e-02	-3.09	urinary_tract-carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma	16	1	16828	49	FGFR3
4.570e-02	-3.09	protein trimerization	biological process	GO:0070206	17	1	18204	50	SLC1A2
4.570e-02	-3.09	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	50	ATP1A2
4.570e-02	-3.09	regulation of trophoblast cell migration	biological process	GO:1901163	17	1	18204	50	GJA1
4.570e-02	-3.09	viral genome replication	biological process	GO:0019079	17	1	18204	50	NFIA
4.570e-02	-3.09	cellular response to ATP	biological process	GO:0071318	17	1	18204	50	RYR3
4.570e-02	-3.09	ureter development	biological process	GO:0072189	17	1	18204	50	NFIA
4.570e-02	-3.09	microvillus assembly	biological process	GO:0030033	17	1	18204	50	TNIK
4.570e-02	-3.09	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	50	SORBS1
4.570e-02	-3.09	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	50	CTNNA2
4.574e-02	-3.08	SH3	prosite domains	PS50002	222	3	12186	44	MACF1,NEBL,SORBS1
4.596e-02	-3.08	ZnF_GATA	smart domains	SM00401	12	1	9717	38	TRPS1
4.596e-02	-3.08	DWA	smart domains	SM00523	12	1	9717	38	NFIA
4.596e-02	-3.08	CARBOXYPEPT_ZN_1	prosite domains	PS00132	13	1	12186	44	CPE
4.596e-02	-3.08	CARBOXYPEPT_ZN_2	prosite domains	PS00133	13	1	12186	44	CPE
4.615e-02	-3.08	cell cortex	cellular component	GO:0005938	313	3	19108	49	PARD3,PARD3B,ITPR2
4.622e-02	-3.07	Methadone Action Pathway	SMPDB pathways	SMP0000408	32	1	1369	2	ATP1A2
4.622e-02	-3.07	Nicotine Action Pathway	SMPDB pathways	SMP0000431	32	1	1369	2	ATP1A2
4.622e-02	-3.07	Citalopram Action Pathway	SMPDB pathways	SMP0000424	32	1	1369	2	ATP1A2
4.623e-02	-3.07	ion binding	molecular function	GO:0043167	6007	22	18094	48	PON2,RYR3,GLUL,ITPR2,ABLIM1,SPON1,TRPS1,SPARCL1,SLC1A2,MACF1,BMPR1B,ZNRF3,SLC1A3,ATP1A2,PARD3,ATP13A4,DTNA,ZBTB20,TNIK,PITPNC1,CPE,FGFR3
4.626e-02	-3.07	actomyosin structure organization	biological process	GO:0031032	125	2	18204	50	NEBL,SORBS1
4.631e-02	-3.07	cellular response to growth factor stimulus	biological process	GO:0071363	494	4	18204	50	NFIA,SOX5,BMPR1B,FGFR3
4.634e-02	-3.07	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	28	16828	49	PON2,LRIG1,NPAS3,TRPS1,SLC1A3,ABLIM1,ITPR2,LIFR,ATP1A2,NKAIN3,PARD3B,DTNA,RYR3,TNIK,SOX5,SPARCL1,PREX2,NEBL,SLC4A4,ATP13A4,GLUL,PARD3,MACF1,ZBTB20,SORBS1,CTNND2,PTPRZ1,FGFR3
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.673e-02	-3.06	ZZ	pfam domains	PF00569	17	1	17795	50	DTNA
4.673e-02	-3.06	Carb_anhydrase	pfam domains	PF00194	17	1	17795	50	PTPRZ1
4.715e-02	-3.05	DVL2 (dishevelled segment polarity protein 2)	protein interactions	1856	531	4	19454	50	MACF1,ZNRF3,PARD3,LIFR
4.716e-02	-3.05	FOXP1 (forkhead box P1)	protein interactions	27086	135	2	19454	50	SOX5,NFIA
4.716e-02	-3.05	SOX15 (SRY-box transcription factor 15)	protein interactions	6665	135	2	19454	50	TRPS1,NFIA
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	AHCYL2,CDH20,ITPR2,LIFR,DTNA,RYR3,PARD3B,PREX2,SPARCL1,MSI2,GPC5,GPM6A,LRIG1,CPE,SLC1A3,FBXL7,TRPS1,PITPNC1,NHSL1,SFXN5,SORBS1,RFX4,MEIS2,ZNRF3,SLC4A4,ATP13A4,NFIA,NKAIN3,AQP4,ATP1A2,LSAMP,SOX5,TNIK,PON2,NTM,ABLIM1,NPAS3,ZBTB20,MACF1,BMPR1B,PTPRZ1,FGFR3,CTNND2,SLC1A2,GJA1,NEBL,SPON1,GLUL,PARD3
4.752e-02	-3.05	Leu-rich_rpt_4	interpro domains	IPR025875	18	1	18521	50	LRIG1
4.752e-02	-3.05	Leu-rich_rpt_Cys-con_subtyp	interpro domains	IPR006553	18	1	18521	50	FBXL7
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.774e-02	-3.04	PCDH19 (protocadherin 19)	protein interactions	57526	19	1	19454	50	GJA1
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	DEFB125 (defensin beta 125)	protein interactions	245938	19	1	19454	50	GJA1
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	LIFR
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.775e-02	-3.04	brain development	biological process	GO:0007420	724	5	18204	50	SLC1A2,RFX4,ATP1A2,MEIS2,CTNNA2
4.779e-02	-3.04	NIBAN2 (niban apoptosis regulator 2)	protein interactions	64855	136	2	19454	50	GJA1,GLUL
4.793e-02	-3.04	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	3	16828	49	PREX2,ATP1A2,TNIK
4.832e-02	-3.03	dicarboxylic acid catabolic process	biological process	GO:0043649	18	1	18204	50	GLUL
4.832e-02	-3.03	positive regulation of myelination	biological process	GO:0031643	18	1	18204	50	PARD3
4.832e-02	-3.03	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	50	ATP1A2
4.832e-02	-3.03	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	50	CTNND2
4.832e-02	-3.03	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	50	NEBL
4.832e-02	-3.03	receptor catabolic process	biological process	GO:0032801	18	1	18204	50	ZNRF3
4.839e-02	-3.03	skin-other-verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	skin-other-verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	breast-carcinoma-neuroendocrine_carcinoma	COSMIC cancer mutations	breast-carcinoma-neuroendocrine_carcinoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	non_chronically_sun_exposed_site	COSMIC cancer mutations	non_chronically_sun_exposed_site	17	1	16828	49	FGFR3
4.839e-02	-3.03	verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-non_chronically_sun_exposed_site-malignant_melanoma	COSMIC cancer mutations	skin-non_chronically_sun_exposed_site-malignant_melanoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.842e-02	-3.03	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	2	19454	50	NFIA,SOX5
4.842e-02	-3.03	CDC42BPA (CDC42 binding protein kinase alpha)	protein interactions	8476	137	2	19454	50	GJA1,PARD3
4.848e-02	-3.03	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	REACTOME pathways	R-HSA-2173791	17	1	10285	30	PARD3
4.848e-02	-3.03	Elevation of cytosolic Ca2+ levels	REACTOME pathways	R-HSA-139853	17	1	10285	30	ITPR2
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.875e-02	-3.02	Nitrogen metabolism	KEGG pathways	hsa00910	17	1	7161	21	GLUL
4.875e-02	-3.02	Nitrogen metabolism	KEGG pathways	ko00910	17	1	7161	21	GLUL
4.894e-02	-3.02	response to organophosphorus	biological process	GO:0046683	129	2	18204	50	RYR3,ITPR2
4.907e-02	-3.01	Trichlormethiazide Action Pathway	SMPDB pathways	SMP0000121	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Torsemide Action Pathway	SMPDB pathways	SMP0000118	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Hartnup Disorder	SMPDB pathways	SMP0000189	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Methyclothiazide Action Pathway	SMPDB pathways	SMP0000081	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Indapamide Action Pathway	SMPDB pathways	SMP0000110	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Chlorthalidone Action Pathway	SMPDB pathways	SMP0000122	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Cystinuria	SMPDB pathways	SMP0000723	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Cyclothiazide Action Pathway	SMPDB pathways	SMP0000103	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Quinethazone Action Pathway	SMPDB pathways	SMP0000091	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Iminoglycinuria	SMPDB pathways	SMP0000193	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Lysinuric Protein Intolerance (LPI)	SMPDB pathways	SMP0000585	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Spironolactone Action Pathway	SMPDB pathways	SMP0000134	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Furosemide Action Pathway	SMPDB pathways	SMP0000115	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Eplerenone Action Pathway	SMPDB pathways	SMP0000135	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Kidney Function	SMPDB pathways	SMP0000483	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Chlorothiazide Action Pathway	SMPDB pathways	SMP0000078	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Ethacrynic Acid Action Pathway	SMPDB pathways	SMP0000097	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Lysinuric Protein Intolerance	SMPDB pathways	SMP0000197	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Glucose Transporter Defect (SGLT2)	SMPDB pathways	SMP0000184	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Bendroflumethiazide Action Pathway	SMPDB pathways	SMP0000090	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Metolazone Action Pathway	SMPDB pathways	SMP0000105	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Hydroflumethiazide Action Pathway	SMPDB pathways	SMP0000108	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Polythiazide Action Pathway	SMPDB pathways	SMP0000080	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Bumetanide Action Pathway	SMPDB pathways	SMP0000088	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Amiloride Action Pathway	SMPDB pathways	SMP0000133	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Hydrochlorothiazide Action Pathway	SMPDB pathways	SMP0000100	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Blue Diaper Syndrome	SMPDB pathways	SMP0000583	34	1	1369	2	ATP1A2
4.907e-02	-3.01	Triamterene Action Pathway	SMPDB pathways	SMP0000132	34	1	1369	2	ATP1A2
4.924e-02	-3.01	water transmembrane transporter activity	molecular function	GO:0005372	19	1	18094	48	AQP4
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	SORBS1,DTNA,MACF1
4.941e-02	-3.01	LRR_4	pfam domains	PF12799	18	1	17795	50	LRIG1
4.987e-02	-3.00	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	2	18094	48	ITPR2,RYR3