Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
1.086e-11	-25.25	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	26	16828	49	ADCY2,NHSL1,LSAMP,FBXL7,STON2,ATP13A4,RYR3,CTNND2,CPE,NTRK2,FMN2,GNA14,SHROOM3,PREX2,SLC1A3,SLC1A2,GPM6A,GLI3,GABRB1,RFX4,GPC5,NPAS3,CACHD1,NKAIN3,BMPR1B,SOX5
1.086e-11	-25.25	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	26	16828	49	GPC5,NPAS3,CACHD1,NKAIN3,BMPR1B,SOX5,SLC1A3,PREX2,SLC1A2,GPM6A,GLI3,GABRB1,RFX4,STON2,ATP13A4,RYR3,CTNND2,CPE,NTRK2,FMN2,GNA14,SHROOM3,ADCY2,NHSL1,LSAMP,FBXL7
1.647e-09	-20.22	brainstem	COSMIC cancer mutations	brainstem	3102	28	16828	49	PREX2,SLC1A3,ZNRF3,SLC1A2,GLI3,RORA,GPM6A,GABRB1,NPAS3,GPC5,SOX5,NKAIN3,CACHD1,RANBP3L,ADCY2,LSAMP,FBXL7,SFXN5,TNIK,ATP13A4,STON2,CTNND2,RYR3,FMN2,CPE,SHROOM3,FGFR3,GNA14
3.796e-09	-19.39	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	25	16828	49	GPM6A,RORA,GLI3,GABRB1,ZNRF3,SLC1A3,PREX2,CACHD1,NKAIN3,SOX5,RANBP3L,GPC5,SFXN5,FBXL7,TNIK,ADCY2,LSAMP,CPE,FMN2,GNA14,SHROOM3,STON2,ATP13A4,RYR3,CTNND2
5.459e-09	-19.03	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	29	16828	49	SLC4A4,NPAS3,GPC5,MACF1,BMPR1B,CACHD1,RANBP3L,SLC1A3,PREX2,PAMR1,ZNRF3,GLI3,DTNA,GABRB1,STON2,CTNND2,RYR3,FMN2,NTRK2,CPE,PARD3B,SHROOM3,MGAT4C,PITPNC1,ADCY2,LSAMP,FBXL7,MSI2,TNIK
5.459e-09	-19.03	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	29	16828	49	TNIK,MSI2,FBXL7,LSAMP,MGAT4C,PITPNC1,ADCY2,SHROOM3,PARD3B,FMN2,CPE,NTRK2,CTNND2,RYR3,STON2,GABRB1,GLI3,DTNA,PAMR1,SLC1A3,PREX2,ZNRF3,RANBP3L,BMPR1B,MACF1,CACHD1,NPAS3,SLC4A4,GPC5
8.164e-09	-18.62	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	26	16828	49	LSAMP,HIF3A,ADCY2,FBXL7,SFXN5,CTNND2,RYR3,ATP13A4,SHROOM3,PARD3B,GNA14,FMN2,NTRK2,CPE,SLC1A2,PREX2,SLC1A3,ZNRF3,RFX4,GABRB1,GLI3,GPM6A,GPC5,SOX5,NKAIN3,CACHD1
8.189e-09	-18.62	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	30	16828	49	FBXL7,TNIK,MGAT4C,HIF3A,ADCY2,LSAMP,FMN2,GLIS3,NTRK2,CPE,SHROOM3,GNA14,ATP13A4,CTNND2,RYR3,GLI3,RORA,GPM6A,GABRB1,SLC1A3,PREX2,PAMR1,SLC1A2,SOX5,BMPR1B,NKAIN3,CACHD1,NTM,SLC4A4,GPC5
8.189e-09	-18.62	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	30	16828	49	GABRB1,GPM6A,GLI3,RORA,SLC1A2,PREX2,SLC1A3,PAMR1,NTM,CACHD1,SOX5,NKAIN3,BMPR1B,GPC5,SLC4A4,TNIK,FBXL7,LSAMP,HIF3A,ADCY2,MGAT4C,GNA14,SHROOM3,GLIS3,NTRK2,CPE,FMN2,RYR3,CTNND2,ATP13A4
1.166e-08	-18.27	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	31	16828	49	GPC5,NKAIN3,MACF1,SOX5,CACHD1,ATP1A2,RANBP3L,SLC1A3,PREX2,SPARCL1,SLC1A2,RORA,GLI3,DTNA,GPM6A,GABRB1,STON2,ATP13A4,CTNND2,RYR3,FMN2,CPE,NTRK2,FGFR3,SHROOM3,GNA14,AQP4,ADCY2,LSAMP,FBXL7,TNIK
1.500e-08	-18.01	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	17	16828	49	FGFR3,GNA14,NKAIN3,BMPR1B,SOX5,CACHD1,NTRK2,ATP1A2,RYR3,NPAS3,TNIK,GABRB1,FBXL7,LSAMP,SLC1A2,PREX2,ADCY2
1.500e-08	-18.01	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	17	16828	49	SLC1A2,LSAMP,ADCY2,PREX2,GABRB1,TNIK,FBXL7,RYR3,NPAS3,GNA14,FGFR3,ATP1A2,NTRK2,CACHD1,SOX5,BMPR1B,NKAIN3
1.947e-08	-17.75	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	25	16828	49	GPC5,SOX5,NKAIN3,CACHD1,SLC1A2,PREX2,SLC1A3,ZNRF3,RFX4,GABRB1,GLI3,GPM6A,CTNND2,RYR3,SHROOM3,PARD3B,GNA14,FMN2,NTRK2,CPE,LSAMP,HIF3A,ADCY2,FBXL7,SFXN5
2.157e-08	-17.65	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	14	16828	49	FBXL7,GABRB1,ADCY2,PREX2,SLC1A2,LSAMP,ATP1A2,NTRK2,CACHD1,SOX5,NKAIN3,GNA14,GPC5,RYR3
2.815e-08	-17.39	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	40	16828	49	FMN2,CPE,NTRK2,GLIS3,FGFR3,SHROOM3,PARD3B,ABLIM1,GNA14,STON2,ATP13A4,CTNND2,SORBS1,RYR3,SFXN5,FBXL7,GLUD1,TNIK,NHSL1,PITPNC1,ADCY2,LSAMP,NKAIN3,SOX5,MACF1,CACHD1,NTM,RANBP3L,SLC4A4,NPAS3,GPC5,RORA,GLI3,GPM6A,RFX4,GABRB1,PAMR1,PREX2,SLC1A3,SLC1A2
2.942e-08	-17.34	plasma membrane	cellular component	GO:0005886	5538	33	19108	49	ATP13A4,NTM,GNA14,NKAIN3,TNIK,NTRK2,CTNND2,CTNNA2,BMPR1B,ZNRF3,FMN2,FGFR3,SORBS1,GPM6A,CACHD1,RYR3,STON2,HIF3A,GPC5,GABRB1,SLC1A3,DTNA,SHROOM3,AQP4,PARD3B,ATP1A2,ADCY2,CPE,PREX2,LSAMP,SLC4A4,MACF1,SLC1A2
5.023e-08	-16.81	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	44	16828	49	ATP13A4,RYR3,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,ADCY2,PITPNC1,NPAS3,BMPR1B,SLC1A3,GPM6A,STON2,SORBS1,CTNND2,NTRK2,CPE,ABLIM1,FGFR3,HIF3A,NHSL1,LSAMP,FBXL7,GLUD1,SFXN5,MSI2,TNIK,GPC5,SLC4A4,CACHD1,MACF1,SOX5,NKAIN3,NTM,SPARCL1,ZNRF3,PREX2,SLC1A2,DTNA,GLI3,RORA,GABRB1,RFX4
5.448e-08	-16.73	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	28	16828	49	GPC5,RANBP3L,SOX5,MACF1,NKAIN3,ATP1A2,CACHD1,SLC1A2,PREX2,SPARCL1,GABRB1,GLI3,RORA,GPM6A,CTNND2,RYR3,ATP13A4,STON2,SHROOM3,FGFR3,GNA14,FMN2,CPE,LSAMP,AQP4,ADCY2,TNIK,FBXL7
5.657e-08	-16.69	cell periphery	cellular component	GO:0071944	6020	34	19108	49	CPE,PREX2,ADCY2,MACF1,SLC1A2,LSAMP,SLC4A4,SLC1A3,DTNA,AQP4,PARD3B,ATP1A2,SHROOM3,GPM6A,SORBS1,CACHD1,RYR3,BMPR1B,FMN2,ZNRF3,FGFR3,HIF3A,GPC5,GABRB1,STON2,GNA14,ATP13A4,NTM,NTRK2,CTNND2,CTNNA2,NKAIN3,TNIK,SPARCL1
1.593e-07	-15.65	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	49	16828	49	RYR3,ATP13A4,SHROOM3,PARD3B,GNA14,FMN2,GLIS3,AQP4,PITPNC1,ADCY2,NPAS3,RANBP3L,BMPR1B,ATP1A2,PAMR1,SLC1A3,GPM6A,CTNND2,SORBS1,STON2,FGFR3,ABLIM1,CPE,NTRK2,LSAMP,NHSL1,MGAT4C,HIF3A,TNIK,MSI2,SFXN5,FBXL7,GLUD1,SLC4A4,GPC5,NTM,NKAIN3,SOX5,MACF1,CACHD1,SLC1A2,PREX2,ZNRF3,SPARCL1,RFX4,GABRB1,RORA,DTNA,GLI3
2.894e-07	-15.06	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	11	16828	49	ADCY2,LSAMP,GPM6A,SFXN5,GABRB1,GPC5,CTNND2,RYR3,SOX5,NKAIN3,FMN2
5.280e-07	-14.45	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	14	19454	50	GLUD1,MACF1,SLC4A4,CPE,ATP1A2,SORBS1,NHSL1,SPARCL1,ABLIM1,LSAMP,GPM6A,MSI2,AQP4,SLC1A3
6.069e-07	-14.31	lymph_node	COSMIC cancer mutations	lymph_node	1703	18	16828	49	FGFR3,RANBP3L,PARD3B,SHROOM3,SOX5,NTRK2,CTNND2,RYR3,STON2,ATP13A4,GPC5,TNIK,GABRB1,DTNA,GPM6A,SFXN5,LSAMP,SLC1A3
6.567e-07	-14.24	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	17	16828	49	CACHD1,NTRK2,FMN2,NKAIN3,SOX5,SHROOM3,GPC5,RYR3,CTNND2,FBXL7,RORA,GLI3,GABRB1,ADCY2,SLC1A3,PREX2,LSAMP
6.567e-07	-14.24	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	17	16828	49	CTNND2,RYR3,GPC5,SHROOM3,FMN2,NKAIN3,SOX5,CACHD1,NTRK2,LSAMP,PREX2,SLC1A3,ADCY2,GABRB1,RORA,GLI3,FBXL7
1.565e-06	-13.37	nervous system development	biological process	GO:0007399	2185	19	18204	49	GLUD1,RORA,GLI3,GABRB1,SOX5,RFX4,SLC1A3,NTM,TNIK,LSAMP,CTNND2,CTNNA2,NTRK2,BMPR1B,PREX2,GPM6A,ATP1A2,MSI2,SLC1A2
1.742e-06	-13.26	pharynx	COSMIC cancer mutations	pharynx	2696	22	16828	49	SORBS1,CTNND2,RYR3,SLC4A4,ATP13A4,NPAS3,GPC5,SHROOM3,PARD3B,FGFR3,MACF1,FMN2,NTRK2,ATP1A2,SLC1A2,PREX2,PITPNC1,NHSL1,RFX4,GABRB1,DTNA,SFXN5
2.277e-06	-12.99	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	8	16828	49	GABRB1,SFXN5,GPM6A,SOX5,NKAIN3,FMN2,GPC5,ADCY2
3.130e-06	-12.67	humerus	COSMIC cancer mutations	humerus	546	10	16828	49	GPM6A,SFXN5,SOX5,NKAIN3,FMN2,GABRB1,PARD3B,HIF3A,GPC5,ADCY2
4.959e-06	-12.21	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	37	16828	49	GLUD1,FBXL7,SFXN5,TNIK,MGAT4C,NHSL1,ADCY2,LSAMP,FMN2,GLIS3,NTRK2,CPE,PARD3B,SHROOM3,ABLIM1,GNA14,ATP13A4,STON2,CTNND2,RYR3,GLI3,RORA,GPM6A,RFX4,GABRB1,SLC1A3,PREX2,PAMR1,SPARCL1,SLC1A2,MACF1,SOX5,BMPR1B,NKAIN3,CACHD1,RANBP3L,GPC5
5.631e-06	-12.09	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	14	16828	49	SOX5,NKAIN3,CACHD1,RANBP3L,GNA14,STON2,GPC5,CTNND2,RORA,TNIK,GABRB1,AQP4,ADCY2,LSAMP
6.125e-06	-12.00	multicellular organism development	biological process	GO:0007275	3957	25	18204	49	RFX4,NTM,TNIK,CPE,NTRK2,GPM6A,HIF3A,ATP1A2,SLC1A2,LSAMP,SHROOM3,SLC1A3,FGFR3,GLUD1,RORA,SOX5,GABRB1,GLI3,BMPR1B,CTNNA2,PREX2,ZNRF3,MSI2,RANBP3L,CTNND2
7.967e-06	-11.74	generation of neurons	biological process	GO:0048699	1158	13	18204	49	PREX2,GPM6A,CTNNA2,BMPR1B,NTRK2,CTNND2,TNIK,SLC1A3,NTM,GLI3,GABRB1,SOX5,RORA
9.320e-06	-11.58	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	14	16828	49	NTRK2,FMN2,MACF1,ABLIM1,NTM,FGFR3,ATP13A4,RYR3,CTNND2,GPM6A,GLI3,TNIK,ADCY2,PAMR1
9.320e-06	-11.58	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	14	16828	49	GPM6A,GLI3,TNIK,ADCY2,PAMR1,NTRK2,MACF1,FMN2,ABLIM1,NTM,FGFR3,ATP13A4,RYR3,CTNND2
1.167e-05	-11.36	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	34	16828	49	CACHD1,ATP1A2,BMPR1B,MACF1,SOX5,RANBP3L,GPC5,NPAS3,SLC4A4,GPM6A,GLI3,SPARCL1,PREX2,CPE,GLIS3,FMN2,ABLIM1,GNA14,FGFR3,PARD3B,STON2,ATP13A4,RYR3,CTNND2,SORBS1,SFXN5,FBXL7,GLUD1,TNIK,ADCY2,HIF3A,AQP4,MGAT4C,PITPNC1
1.167e-05	-11.36	system development	biological process	GO:0048731	3533	23	18204	49	MSI2,CTNNA2,BMPR1B,PREX2,RANBP3L,CTNND2,SLC1A3,FGFR3,RORA,GLUD1,GLI3,GABRB1,SOX5,ATP1A2,SLC1A2,NTRK2,HIF3A,GPM6A,LSAMP,NTM,TNIK,RFX4,CPE
1.353e-05	-11.21	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	7	19454	50	STON2,ABLIM1,DTNA,MACF1,CACHD1,FMN2,TNIK
1.359e-05	-11.21	neuron development	biological process	GO:0048666	859	11	18204	49	CTNND2,PREX2,GPM6A,CTNNA2,BMPR1B,NTRK2,GABRB1,GLI3,TNIK,NTM,SLC1A3
1.598e-05	-11.04	nodular	COSMIC cancer mutations	nodular	1515	15	16828	49	PREX2,SPARCL1,HIF3A,FGFR3,ABLIM1,FMN2,MACF1,CPE,ATP1A2,GLIS3,NTRK2,CTNND2,SLC4A4,ATP13A4,NPAS3
1.836e-05	-10.91	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	7	19454	50	MACF1,DTNA,ABLIM1,CTNNA2,NHSL1,TNIK,SORBS1
2.023e-05	-10.81	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	3	18204	49	GLI3,SOX5,BMPR1B
2.153e-05	-10.75	neuron differentiation	biological process	GO:0030182	1081	12	18204	49	SLC1A3,NTM,TNIK,RORA,GABRB1,GLI3,CTNNA2,BMPR1B,NTRK2,PREX2,GPM6A,CTNND2
2.188e-05	-10.73	tibia	COSMIC cancer mutations	tibia	836	11	16828	49	TNIK,GPM6A,LSAMP,PREX2,RANBP3L,FGFR3,ABLIM1,MACF1,NKAIN3,CPE,CTNND2
2.256e-05	-10.70	MAPT (microtubule associated protein tau)	protein interactions	4137	948	11	19454	50	ABLIM1,NTM,LSAMP,CTNND2,GPM6A,SLC1A3,SLC1A2,ATP1A2,TNIK,SORBS1,CTNNA2
2.257e-05	-10.70	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	10	18094	48	SLC1A2,ATP13A4,SFXN5,GPM6A,GABRB1,RYR3,CACHD1,SLC1A3,ATP1A2,SLC4A4
2.353e-05	-10.66	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	31	16828	49	GNA14,SHROOM3,PARD3B,NTRK2,FMN2,RYR3,CTNND2,SORBS1,STON2,ATP13A4,FBXL7,GLUD1,LSAMP,ADCY2,MGAT4C,NTM,CACHD1,ATP1A2,NKAIN3,SOX5,MACF1,GPC5,SLC4A4,NPAS3,GABRB1,GPM6A,DTNA,GLI3,ZNRF3,PAMR1,SLC1A3
2.353e-05	-10.66	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	31	16828	49	NTRK2,FMN2,GNA14,PARD3B,SHROOM3,ATP13A4,STON2,RYR3,SORBS1,CTNND2,GLUD1,FBXL7,ADCY2,MGAT4C,LSAMP,ATP1A2,CACHD1,MACF1,SOX5,NKAIN3,NTM,GPC5,SLC4A4,NPAS3,GPM6A,DTNA,GLI3,GABRB1,ZNRF3,SLC1A3,PAMR1
2.698e-05	-10.52	anatomical structure development	biological process	GO:0048856	5207	28	18204	49	SHROOM3,LSAMP,NTRK2,HIF3A,GPM6A,ATP1A2,SLC1A2,CPE,RFX4,NTM,TNIK,RANBP3L,CTNND2,CTNNA2,BMPR1B,PREX2,ABLIM1,ZNRF3,MSI2,FMN2,RORA,GLUD1,GABRB1,GLI3,SOX5,SPARCL1,SLC1A3,FGFR3
2.933e-05	-10.44	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	17	19108	49	ADCY2,BMPR1B,FMN2,GPM6A,STON2,GABRB1,MACF1,SLC1A2,DTNA,SLC1A3,GLI3,NTRK2,AQP4,CTNND2,ABLIM1,ATP1A2,CTNNA2
3.021e-05	-10.41	cellular response to organic cyclic compound	biological process	GO:0071407	464	8	18204	49	ADCY2,SLC1A2,ATP1A2,SLC1A3,RYR3,GABRB1,GNA14,RORA
3.254e-05	-10.33	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	25	16828	49	HIF3A,ADCY2,PITPNC1,AQP4,NHSL1,FBXL7,TNIK,RYR3,CTNND2,GLIS3,NTRK2,FMN2,PARD3B,FGFR3,ZNRF3,PREX2,SLC1A2,GPM6A,GLI3,RFX4,SLC4A4,NPAS3,ATP1A2,CACHD1,MACF1
3.599e-05	-10.23	neurogenesis	biological process	GO:0022008	1334	13	18204	49	TNIK,NTM,SLC1A3,GLI3,GABRB1,SOX5,RORA,PREX2,GPM6A,CTNNA2,NTRK2,BMPR1B,CTNND2
3.641e-05	-10.22	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	14	16828	49	PITPNC1,PREX2,NHSL1,SLC1A2,SFXN5,RFX4,ATP13A4,SLC4A4,CTNND2,ATP1A2,NTRK2,FMN2,SHROOM3,FGFR3
3.641e-05	-10.22	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	14	16828	49	SFXN5,RFX4,PREX2,PITPNC1,NHSL1,SLC1A2,NTRK2,ATP1A2,FMN2,SHROOM3,FGFR3,ATP13A4,SLC4A4,CTNND2
4.204e-05	-10.08	RHOB (ras homolog family member B)	protein interactions	388	832	10	19454	50	STON2,DTNA,ABLIM1,CACHD1,MACF1,FMN2,SLC1A3,PARD3B,SHROOM3,TNIK
4.284e-05	-10.06	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	3	7161	22	SLC4A4,ATP1A2,GLUD1
4.284e-05	-10.06	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	3	7161	22	SLC4A4,ATP1A2,GLUD1
4.581e-05	-9.99	monoatomic ion transmembrane transport	biological process	GO:0034220	804	10	18204	49	GABRB1,SLC1A3,RYR3,CACHD1,ATP1A2,SFXN5,SLC1A2,ATP13A4,SLC4A4,GPM6A
4.917e-05	-9.92	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	30	SLC1A2,SLC1A3
4.917e-05	-9.92	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	30	SLC1A2,SLC1A3
5.135e-05	-9.88	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	43	16828	49	FBXL7,SFXN5,TNIK,MGAT4C,HIF3A,LSAMP,NTRK2,CPE,FGFR3,ABLIM1,STON2,SORBS1,CTNND2,DTNA,GLI3,RORA,RFX4,GABRB1,PREX2,ZNRF3,SLC1A2,SOX5,MACF1,NKAIN3,CACHD1,NTM,SLC4A4,GPC5,PITPNC1,ADCY2,FMN2,GLIS3,SHROOM3,PARD3B,ATP13A4,RYR3,GPM6A,SLC1A3,PAMR1,BMPR1B,ATP1A2,RANBP3L,NPAS3
5.135e-05	-9.88	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	43	16828	49	SFXN5,FBXL7,TNIK,PITPNC1,MGAT4C,ADCY2,HIF3A,LSAMP,FMN2,CPE,NTRK2,GLIS3,FGFR3,SHROOM3,PARD3B,ABLIM1,STON2,ATP13A4,CTNND2,SORBS1,RYR3,RORA,GLI3,DTNA,GPM6A,RFX4,GABRB1,PAMR1,SLC1A3,PREX2,ZNRF3,SLC1A2,BMPR1B,NKAIN3,SOX5,MACF1,CACHD1,ATP1A2,NTM,RANBP3L,SLC4A4,NPAS3,GPC5
5.275e-05	-9.85	central nervous system development	biological process	GO:0007417	995	11	18204	49	RORA,GLUD1,GLI3,GABRB1,CTNNA2,BMPR1B,RFX4,NTRK2,ATP1A2,MSI2,SLC1A2
5.381e-05	-9.83	developmental process	biological process	GO:0032502	5716	29	18204	49	SPARCL1,FGFR3,SLC1A3,GLI3,GABRB1,SOX5,FMN2,RORA,GLUD1,PREX2,ABLIM1,CTNNA2,BMPR1B,MSI2,ZNRF3,CTNND2,RANBP3L,RFX4,TNIK,NTM,CPE,HIF3A,GPM6A,NTRK2,SLC1A2,ATP1A2,SHROOM3,LSAMP,NHSL1
5.476e-05	-9.81	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	35	16828	49	SLC1A2,PAMR1,PREX2,SLC1A3,RFX4,GABRB1,RORA,GLI3,GPM6A,SLC4A4,GPC5,RANBP3L,NKAIN3,BMPR1B,MACF1,SOX5,CACHD1,ATP1A2,LSAMP,NHSL1,ADCY2,SFXN5,FBXL7,CTNND2,RYR3,STON2,ATP13A4,FGFR3,SHROOM3,GNA14,ABLIM1,FMN2,CPE,NTRK2,GLIS3
5.477e-05	-9.81	cell projection	cellular component	GO:0042995	2398	17	19108	49	STON2,MACF1,GABRB1,SLC1A2,BMPR1B,ADCY2,FMN2,GPM6A,AQP4,CTNND2,NTRK2,ABLIM1,ATP1A2,CTNNA2,DTNA,SLC1A3,GLI3
5.590e-05	-9.79	transporter activity	molecular function	GO:0005215	1211	12	18094	48	SLC1A2,PITPNC1,SFXN5,ATP13A4,CACHD1,RYR3,GABRB1,GPM6A,SLC4A4,ATP1A2,AQP4,SLC1A3
5.672e-05	-9.78	Bile secretion	KEGG pathways	hsa04976	71	4	7161	22	ADCY2,AQP4,ATP1A2,SLC4A4
5.672e-05	-9.78	Bile secretion	KEGG pathways	ko04976	71	4	7161	22	SLC4A4,ATP1A2,AQP4,ADCY2
6.028e-05	-9.72	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	12	16828	49	MACF1,FGFR3,NTM,ATP13A4,SLC4A4,SORBS1,CTNND2,GLI3,GABRB1,MGAT4C,PREX2,ADCY2
6.287e-05	-9.67	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	8	16828	49	SFXN5,GPM6A,GABRB1,ATP13A4,GPC5,CTNND2,RYR3,LSAMP
6.504e-05	-9.64	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	34	16828	49	ATP1A2,MACF1,SOX5,RANBP3L,NTM,GPC5,SLC4A4,GPM6A,DTNA,GLI3,RORA,RFX4,ZNRF3,PREX2,PAMR1,SLC1A2,FMN2,ABLIM1,SHROOM3,PARD3B,FGFR3,ATP13A4,RYR3,SORBS1,CTNND2,FBXL7,SFXN5,TNIK,HIF3A,ADCY2,PITPNC1,MGAT4C,NHSL1,LSAMP
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A2,SLC1A3
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A3,SLC1A2
6.922e-05	-9.58	plasma membrane region	cellular component	GO:0098590	1278	12	19108	49	SORBS1,GPM6A,SLC1A3,AQP4,ATP1A2,PARD3B,SLC1A2,GABRB1,MACF1,TNIK,SHROOM3,SLC4A4
7.061e-05	-9.56	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	49	SLC1A3,SLC1A2
7.061e-05	-9.56	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	49	SLC1A2,SLC1A3
7.070e-05	-9.56	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	49	SLC1A2,ATP1A2,SLC1A3
7.817e-05	-9.46	cell morphogenesis	biological process	GO:0000902	687	9	18204	49	TNIK,SLC1A3,PREX2,GPM6A,CTNNA2,BMPR1B,GLI3,CTNND2,SHROOM3
7.937e-05	-9.44	prostate	COSMIC cancer mutations	prostate	13883	49	16828	49	RANBP3L,BMPR1B,ATP1A2,NPAS3,GPM6A,SLC1A3,PAMR1,SHROOM3,PARD3B,GNA14,FMN2,GLIS3,RYR3,ATP13A4,PITPNC1,AQP4,ADCY2,NTM,SOX5,MACF1,NKAIN3,CACHD1,SLC4A4,GPC5,RFX4,GABRB1,GLI3,DTNA,RORA,SLC1A2,PREX2,ZNRF3,SPARCL1,FGFR3,ABLIM1,NTRK2,CPE,SORBS1,CTNND2,STON2,MSI2,TNIK,FBXL7,GLUD1,SFXN5,LSAMP,MGAT4C,NHSL1,HIF3A
7.991e-05	-9.43	chondrocyte differentiation	biological process	GO:0002062	85	4	18204	49	FGFR3,GLI3,SOX5,BMPR1B
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	GPM6A,LSAMP,NTM
8.305e-05	-9.40	cell junction	cellular component	GO:0030054	2224	16	19108	49	GABRB1,SLC1A2,STON2,GPM6A,SORBS1,FGFR3,ATP1A2,PARD3B,CTNNA2,NTRK2,CTNND2,SPARCL1,SHROOM3,TNIK,DTNA,SLC1A3
8.349e-05	-9.39	multicellular organismal process	biological process	GO:0032501	6177	30	18204	49	ATP1A2,RYR3,SLC1A2,SLC4A4,NTRK2,HIF3A,GPM6A,SHROOM3,LSAMP,DTNA,NTM,TNIK,RFX4,AQP4,CPE,ZNRF3,MSI2,CTNNA2,BMPR1B,PREX2,ABLIM1,RANBP3L,CTNND2,SLC1A3,FGFR3,GLUD1,RORA,GLI3,GABRB1,SOX5
8.364e-05	-9.39	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	49	ATP1A2,SLC1A3,SLC1A2,SLC4A4
8.364e-05	-9.39	vascular transport	biological process	GO:0010232	86	4	18204	49	SLC1A2,SLC1A3,ATP1A2,SLC4A4
8.604e-05	-9.36	positive regulation of cartilage development	biological process	GO:0061036	32	3	18204	49	BMPR1B,SOX5,GLI3
8.970e-05	-9.32	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	9	10285	30	GABRB1,SLC1A2,SLC4A4,ATP1A2,RYR3,ADCY2,ATP13A4,AQP4,SLC1A3
8.991e-05	-9.32	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	36	16828	49	RFX4,GABRB1,RORA,GLI3,GPM6A,SLC1A2,PAMR1,PREX2,SLC1A3,RANBP3L,NKAIN3,BMPR1B,SOX5,MACF1,CACHD1,ATP1A2,SLC4A4,GPC5,TNIK,SFXN5,FBXL7,LSAMP,NHSL1,ADCY2,FGFR3,SHROOM3,GNA14,ABLIM1,FMN2,CPE,GLIS3,NTRK2,CTNND2,RYR3,STON2,ATP13A4
9.290e-05	-9.28	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	9	18094	48	SLC4A4,AQP4,ATP1A2,SLC1A3,CACHD1,RYR3,GPM6A,GABRB1,SLC1A2
9.314e-05	-9.28	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	24	16828	49	PARD3B,FGFR3,NTRK2,GLIS3,FMN2,RYR3,CTNND2,TNIK,FBXL7,HIF3A,ADCY2,PITPNC1,AQP4,ATP1A2,CACHD1,MACF1,NPAS3,SLC4A4,RFX4,GPM6A,GLI3,SLC1A2,ZNRF3,PREX2
9.354e-05	-9.28	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	24	16828	49	ATP1A2,CACHD1,MACF1,SLC4A4,NPAS3,RFX4,GPM6A,GLI3,SLC1A2,ZNRF3,PREX2,PARD3B,FGFR3,NTRK2,GLIS3,FMN2,RYR3,CTNND2,TNIK,FBXL7,HIF3A,ADCY2,PITPNC1,AQP4
9.404e-05	-9.27	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	11	16828	49	CTNND2,LSAMP,STON2,ADCY2,GPC5,GABRB1,GNA14,NKAIN3,RORA,SOX5,CACHD1
9.782e-05	-9.23	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	17	16828	49	GPC5,RYR3,CTNND2,NTRK2,SOX5,NKAIN3,FMN2,FGFR3,ADCY2,SLC1A3,PREX2,LSAMP,SLC1A2,FBXL7,GPM6A,GLI3,GABRB1
1.012e-04	-9.20	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	25	16828	49	ATP13A4,RYR3,SORBS1,CTNND2,NTRK2,FMN2,SHROOM3,PARD3B,FGFR3,HIF3A,ADCY2,NHSL1,FBXL7,TNIK,SLC4A4,CACHD1,SOX5,MACF1,RANBP3L,NTM,PREX2,GPM6A,GLI3,GABRB1,RFX4
1.023e-04	-9.19	neuron projection	cellular component	GO:0043005	1331	12	19108	49	GPM6A,ADCY2,BMPR1B,SLC1A2,GABRB1,STON2,DTNA,SLC1A3,ATP1A2,CTNNA2,CTNND2,NTRK2
1.023e-04	-9.19	bone	COSMIC cancer mutations	bone	8157	37	16828	49	ABLIM1,GNA14,PARD3B,SHROOM3,FGFR3,GLIS3,NTRK2,CPE,FMN2,RYR3,SORBS1,CTNND2,ATP13A4,STON2,TNIK,SFXN5,LSAMP,HIF3A,ADCY2,RANBP3L,ATP1A2,CACHD1,SOX5,MACF1,NKAIN3,GPC5,NPAS3,SLC4A4,GABRB1,GPM6A,DTNA,GLI3,RORA,SPARCL1,SLC1A3,PREX2,PAMR1
1.057e-04	-9.15	D-amino acid transport	biological process	GO:0042940	6	2	18204	49	SLC1A2,SLC1A3
1.057e-04	-9.15	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	49	SLC1A2,SLC1A3
1.064e-04	-9.15	GLI-like	interpro domains	IPR043359	6	2	18521	50	GLI3,GLIS3
1.078e-04	-9.13	central nervous system neuron differentiation	biological process	GO:0021953	176	5	18204	49	RORA,GABRB1,GLI3,NTRK2,BMPR1B
1.173e-04	-9.05	adherens junction	cellular component	GO:0005912	188	5	19108	49	CTNNA2,PARD3B,SORBS1,CTNND2,SHROOM3
1.217e-04	-9.01	transmembrane transporter activity	molecular function	GO:0022857	1110	11	18094	48	SLC4A4,ATP1A2,AQP4,SLC1A3,CACHD1,RYR3,GPM6A,GABRB1,SFXN5,ATP13A4,SLC1A2
1.342e-04	-8.92	mouth	COSMIC cancer mutations	mouth	9004	39	16828	49	NHSL1,MGAT4C,PITPNC1,ADCY2,HIF3A,LSAMP,SFXN5,FBXL7,TNIK,STON2,ATP13A4,CTNND2,SORBS1,RYR3,FMN2,NTRK2,FGFR3,PARD3B,SHROOM3,ABLIM1,PAMR1,SLC1A3,PREX2,ZNRF3,SLC1A2,RORA,DTNA,GLI3,GPM6A,RFX4,GABRB1,NPAS3,SLC4A4,GPC5,SOX5,MACF1,ATP1A2,NTM,RANBP3L
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A3,SLC1A2
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A2,SLC1A3
1.489e-04	-8.81	anatomical structure morphogenesis	biological process	GO:0009653	2225	16	18204	49	TNIK,FGFR3,SLC1A3,GLI3,SOX5,RORA,CPE,HIF3A,PREX2,GPM6A,ABLIM1,CTNNA2,BMPR1B,NTRK2,CTNND2,SHROOM3
1.490e-04	-8.81	FLOT1 (flotillin 1)	protein interactions	10211	453	7	19454	50	SORBS1,FMN2,ABLIM1,GLUD1,DTNA,MACF1,SOX5
1.534e-04	-8.78	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	7	18094	48	GPM6A,SLC1A2,CACHD1,RYR3,SLC1A3,SLC4A4,ATP1A2
1.546e-04	-8.77	SDF	pfam domains	PF00375	7	2	17795	49	SLC1A2,SLC1A3
1.565e-04	-8.76	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	49	SLC1A3,RYR3,SLC1A2
1.711e-04	-8.67	cellular response to endogenous stimulus	biological process	GO:0071495	1135	11	18204	49	GABRB1,SOX5,GNA14,NTRK2,BMPR1B,FGFR3,SLC1A2,ATP1A2,RYR3,SORBS1,SLC1A3
1.841e-04	-8.60	beta-catenin binding	molecular function	GO:0008013	107	4	18094	48	GLI3,CTNNA2,RORA,CTNND2
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	LSAMP,CTNND2,GPM6A,NKAIN3
1.879e-04	-8.58	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	44	SLC1A2,SLC1A3
2.060e-04	-8.49	monoatomic ion transport	biological process	GO:0006811	964	10	18204	49	ATP13A4,SLC4A4,GPM6A,SLC1A3,RYR3,CACHD1,ATP1A2,SFXN5,SLC1A2,GABRB1
2.276e-04	-8.39	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	8	18094	48	ATP13A4,SLC1A2,SLC1A3,SLC4A4,ATP1A2,GPM6A,CACHD1,RYR3
2.300e-04	-8.38	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	45	16828	49	GLUD1,FBXL7,SFXN5,TNIK,HIF3A,MGAT4C,NHSL1,LSAMP,NTRK2,CPE,ABLIM1,FGFR3,STON2,SORBS1,CTNND2,DTNA,GLI3,RORA,GABRB1,RFX4,SPARCL1,ZNRF3,PREX2,SLC1A2,CACHD1,MACF1,SOX5,NTM,GPC5,SLC4A4,ADCY2,PITPNC1,GLIS3,FMN2,SHROOM3,PARD3B,ATP13A4,RYR3,GPM6A,SLC1A3,PAMR1,ATP1A2,BMPR1B,RANBP3L,NPAS3
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	LSAMP,NTM
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	LSAMP,NTM
2.328e-04	-8.37	cervix	COSMIC cancer mutations	cervix	11793	45	16828	49	NTRK2,CPE,ABLIM1,FGFR3,STON2,SORBS1,CTNND2,GLUD1,FBXL7,SFXN5,TNIK,HIF3A,MGAT4C,NHSL1,LSAMP,CACHD1,SOX5,MACF1,NTM,GPC5,SLC4A4,GLI3,DTNA,RORA,GABRB1,RFX4,ZNRF3,SPARCL1,PREX2,SLC1A2,GLIS3,FMN2,SHROOM3,PARD3B,ATP13A4,RYR3,ADCY2,PITPNC1,ATP1A2,BMPR1B,RANBP3L,NPAS3,GPM6A,SLC1A3,PAMR1
2.396e-04	-8.34	PAS domain	gene3d domains	3.30.450.20	40	3	14470	44	HIF3A,CACHD1,NPAS3
2.402e-04	-8.33	acidic amino acid transport	biological process	GO:0015800	45	3	18204	49	NTRK2,SLC1A3,SLC1A2
2.531e-04	-8.28	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	12	16828	49	ABLIM1,MACF1,CPE,ATP1A2,GLIS3,NTRK2,CTNND2,ATP13A4,NPAS3,PREX2,SPARCL1,HIF3A
2.564e-04	-8.27	OCLN (occludin)	protein interactions	100506658	495	7	19454	50	MACF1,TNIK,CACHD1,ABLIM1,DTNA,NTRK2,FMN2
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	44	SLC1A2,SLC1A3
2.645e-04	-8.24	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	44	SLC1A3,SLC1A2
2.665e-04	-8.23	uveal_tract	COSMIC cancer mutations	uveal_tract	587	8	16828	49	ADCY2,PREX2,CTNND2,CPE,MACF1,RANBP3L,SHROOM3,FGFR3
2.810e-04	-8.18	membrane protein complex	cellular component	GO:0098796	1261	11	19108	49	CTNNA2,SLC1A2,ATP1A2,GABRB1,STON2,CACHD1,GNA14,SORBS1,RYR3,BMPR1B,SLC1A3
2.855e-04	-8.16	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	15	16828	49	MGAT4C,ZNRF3,GLI3,RORA,GPM6A,TNIK,NPAS3,SLC4A4,RYR3,MACF1,SOX5,BMPR1B,FMN2,PARD3B,FGFR3
2.887e-04	-8.15	larynx	COSMIC cancer mutations	larynx	1948	15	16828	49	FGFR3,PARD3B,BMPR1B,FMN2,MACF1,SOX5,RYR3,NPAS3,SLC4A4,TNIK,RORA,GLI3,GPM6A,MGAT4C,ZNRF3
3.013e-04	-8.11	neuron projection morphogenesis	biological process	GO:0048812	486	7	18204	49	GLI3,CTNND2,TNIK,GPM6A,PREX2,BMPR1B,CTNNA2
3.021e-04	-8.10	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	3	16828	49	ZNRF3,MGAT4C,MACF1
3.021e-04	-8.10	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	3	16828	49	MGAT4C,MACF1,ZNRF3
3.129e-04	-8.07	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	16	16828	49	RYR3,CTNND2,GPC5,NTRK2,NKAIN3,FMN2,SOX5,SLC1A2,LSAMP,ADCY2,SLC1A3,PREX2,GABRB1,GPM6A,FBXL7,GLI3
3.129e-04	-8.07	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	16	16828	49	GABRB1,GLI3,GPM6A,FBXL7,SLC1A2,LSAMP,SLC1A3,PREX2,ADCY2,FMN2,NKAIN3,SOX5,NTRK2,CTNND2,RYR3,GPC5
3.150e-04	-8.06	cellular response to cocaine	biological process	GO:0071314	10	2	18204	49	SLC1A2,SLC1A3
3.150e-04	-8.06	action potential propagation	biological process	GO:0098870	10	2	18204	49	ATP1A2,NTRK2
3.150e-04	-8.06	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	49	NTRK2,ATP1A2
3.190e-04	-8.05	EDTRNSPORT	prints domains	PR00173	7	2	5227	21	SLC1A3,SLC1A2
3.205e-04	-8.05	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	7	18204	49	CTNND2,GLI3,TNIK,BMPR1B,CTNNA2,GPM6A,PREX2
3.234e-04	-8.04	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	31	16828	49	RFX4,GABRB1,GLI3,RORA,GPM6A,SLC1A2,PREX2,SLC1A3,PAMR1,NTM,SOX5,MACF1,NPAS3,SLC4A4,GPC5,FBXL7,SFXN5,MGAT4C,PITPNC1,NHSL1,HIF3A,ADCY2,PARD3B,SHROOM3,FGFR3,ABLIM1,FMN2,SORBS1,CTNND2,RYR3,STON2
3.288e-04	-8.02	cerebellum	COSMIC cancer mutations	cerebellum	769	9	16828	49	NPAS3,GPC5,CTNND2,RYR3,CPE,NTRK2,PARD3B,GABRB1,ABLIM1
3.303e-04	-8.02	eye	COSMIC cancer mutations	eye	606	8	16828	49	CTNND2,ADCY2,PREX2,FGFR3,RANBP3L,SHROOM3,CPE,MACF1
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	SOX5,PREX2,RYR3,SLC1A2
3.407e-04	-7.98	cell projection morphogenesis	biological process	GO:0048858	496	7	18204	49	GLI3,CTNND2,TNIK,BMPR1B,CTNNA2,GPM6A,PREX2
3.844e-04	-7.86	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	49	SLC1A2,SLC1A3
3.844e-04	-7.86	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	49	SLC1A3,SLC1A2
3.906e-04	-7.85	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	49	BMPR1B,SOX5,GLI3
4.282e-04	-7.76	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	49	16828	49	GPC5,SLC4A4,CACHD1,NKAIN3,MACF1,SOX5,NTM,ZNRF3,SPARCL1,PREX2,SLC1A2,RORA,GLI3,DTNA,GABRB1,RFX4,STON2,CTNND2,SORBS1,CPE,NTRK2,ABLIM1,FGFR3,HIF3A,NHSL1,MGAT4C,LSAMP,SFXN5,FBXL7,GLUD1,TNIK,MSI2,NPAS3,ATP1A2,BMPR1B,RANBP3L,PAMR1,SLC1A3,GPM6A,ATP13A4,RYR3,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,ADCY2,AQP4,PITPNC1
4.301e-04	-7.75	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	50	TNIK,MSI2,FMN2,SLC1A3,ABLIM1,DTNA,MACF1,CACHD1
4.342e-04	-7.74	transmembrane transport	biological process	GO:0055085	1264	11	18204	49	RYR3,ATP1A2,CACHD1,SLC1A2,ATP13A4,SLC4A4,GPM6A,AQP4,GABRB1,SLC1A3,SFXN5
4.347e-04	-7.74	amino acid transport	biological process	GO:0006865	132	4	18204	49	NTRK2,SFXN5,SLC1A2,SLC1A3
4.404e-04	-7.73	Ig_I-set	interpro domains	IPR013098	132	4	18521	50	FGFR3,NTRK2,NTM,LSAMP
4.724e-04	-7.66	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	24	16828	49	MGAT4C,NHSL1,HIF3A,ADCY2,CTNND2,RYR3,SHROOM3,FGFR3,ABLIM1,FMN2,GLIS3,SLC1A3,PREX2,ZNRF3,RFX4,GABRB1,DTNA,GLI3,GPM6A,RANBP3L,MACF1,SOX5,ATP1A2,CACHD1
4.724e-04	-7.66	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	24	16828	49	RANBP3L,SOX5,MACF1,CACHD1,ATP1A2,PREX2,SLC1A3,ZNRF3,RFX4,GABRB1,GLI3,DTNA,GPM6A,CTNND2,RYR3,FGFR3,SHROOM3,ABLIM1,FMN2,GLIS3,NHSL1,MGAT4C,ADCY2,HIF3A
4.733e-04	-7.66	I-set	pfam domains	PF07679	132	4	17795	49	LSAMP,NTRK2,NTM,FGFR3
4.778e-04	-7.65	sarcolemma	cellular component	GO:0042383	142	4	19108	49	AQP4,ATP1A2,RYR3,DTNA
5.433e-04	-7.52	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	8	16828	49	RYR3,CTNND2,NPAS3,GABRB1,ABLIM1,PARD3B,NTRK2,CPE
5.442e-04	-7.52	NAKATPASE	prints domains	PR00121	9	2	5227	21	ATP13A4,ATP1A2
5.488e-04	-7.51	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	8	16828	49	NPAS3,CTNND2,RYR3,CPE,NTRK2,PARD3B,ABLIM1,GABRB1
5.726e-04	-7.47	monoatomic anion transmembrane transport	biological process	GO:0098656	142	4	18204	49	SLC1A3,SLC1A2,GABRB1,SLC4A4
6.089e-04	-7.40	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	40	16828	49	HIF3A,PITPNC1,MGAT4C,MSI2,TNIK,GLUD1,FBXL7,RYR3,SORBS1,CTNND2,ATP13A4,STON2,ABLIM1,GNA14,PARD3B,FGFR3,NTRK2,CPE,FMN2,SPARCL1,ZNRF3,PREX2,PAMR1,GABRB1,RFX4,GPM6A,GLI3,DTNA,RORA,GPC5,NPAS3,SLC4A4,RANBP3L,NTM,ATP1A2,CACHD1,MACF1,SOX5,BMPR1B,NKAIN3
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A3,SLC1A2
6.176e-04	-7.39	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	40	16828	49	GLI3,DTNA,RORA,GPM6A,RFX4,GABRB1,PREX2,PAMR1,SPARCL1,ZNRF3,SOX5,MACF1,NKAIN3,BMPR1B,ATP1A2,CACHD1,RANBP3L,NTM,SLC4A4,NPAS3,GPC5,GLUD1,FBXL7,MSI2,TNIK,MGAT4C,PITPNC1,HIF3A,FMN2,NTRK2,CPE,PARD3B,FGFR3,GNA14,ABLIM1,ATP13A4,STON2,SORBS1,CTNND2,RYR3
6.327e-04	-7.37	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	49	ATP1A2,SLC4A4
6.401e-04	-7.35	brain development	biological process	GO:0007420	724	8	18204	49	GLI3,GLUD1,RORA,NTRK2,RFX4,CTNNA2,SLC1A2,ATP1A2
6.803e-04	-7.29	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	49	CTNND2,PREX2,CTNNA2
7.592e-04	-7.18	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	2	19454	50	MACF1,CPE
7.640e-04	-7.18	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	5	16828	49	SHROOM3,FGFR3,GLIS3,MACF1,MGAT4C
7.721e-04	-7.17	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	5	18094	48	SLC1A2,SLC1A3,ATP13A4,SLC4A4,ATP1A2
7.779e-04	-7.16	small_intestine	COSMIC cancer mutations	small_intestine	250	5	16828	49	FGFR3,TNIK,ZNRF3,MACF1,MGAT4C
7.941e-04	-7.14	plasma membrane protein complex	cellular component	GO:0098797	600	7	19108	49	ATP1A2,CTNNA2,STON2,CACHD1,SORBS1,GNA14,BMPR1B
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	SLC4A4,ATP1A2,SLC1A3,SLC1A2
8.309e-04	-7.09	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	5	19454	50	SHROOM3,DTNA,SORBS1,PARD3B,NTRK2
8.421e-04	-7.08	membrane	cellular component	GO:0016020	9220	35	19108	49	RYR3,SORBS1,GPM6A,CACHD1,ZNRF3,FMN2,FGFR3,BMPR1B,GABRB1,HIF3A,GPC5,SFXN5,STON2,GNA14,NTM,ATP13A4,CTNNA2,NTRK2,CTNND2,NKAIN3,TNIK,PREX2,CPE,MGAT4C,ADCY2,MACF1,SLC1A2,SLC4A4,LSAMP,SLC1A3,DTNA,ATP1A2,PARD3B,AQP4,SHROOM3
8.516e-04	-7.07	spindle	COSMIC cancer mutations	spindle	386	6	16828	49	SHROOM3,CTNND2,FGFR3,PREX2,MACF1,CPE
8.541e-04	-7.07	telencephalon development	biological process	GO:0021537	276	5	18204	49	SLC1A2,GLI3,ATP1A2,NTRK2,RFX4
8.632e-04	-7.05	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	7	18094	48	SLC1A3,SLC4A4,ATP1A2,SLC1A2,GPM6A,CACHD1,RYR3
8.745e-04	-7.04	monoatomic anion transport	biological process	GO:0006820	159	4	18204	49	SLC4A4,GABRB1,SLC1A2,SLC1A3
9.554e-04	-6.95	Wnt signaling pathway	biological process	GO:0016055	283	5	18204	49	ZNRF3,CTNND2,TNIK,CPE,MACF1
9.621e-04	-6.95	dendrite	cellular component	GO:0030425	620	7	19108	49	NTRK2,CTNND2,GABRB1,ATP1A2,GPM6A,BMPR1B,ADCY2
9.623e-04	-6.95	actin binding	molecular function	GO:0003779	434	6	18094	48	MACF1,ABLIM1,SORBS1,FMN2,SHROOM3,CTNNA2
9.763e-04	-6.93	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	5	16828	49	FGFR3,RYR3,SLC1A2,PREX2,SOX5
9.803e-04	-6.93	dendritic tree	cellular component	GO:0097447	622	7	19108	49	GABRB1,ATP1A2,CTNND2,NTRK2,GPM6A,ADCY2,BMPR1B
9.890e-04	-6.92	head development	biological process	GO:0060322	774	8	18204	49	RFX4,NTRK2,CTNNA2,ATP1A2,SLC1A2,GLUD1,RORA,GLI3
9.985e-04	-6.91	regulation of cartilage development	biological process	GO:0061035	73	3	18204	49	BMPR1B,SOX5,GLI3
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	GPM6A,LSAMP,NTM
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A2,SLC1A3
1.028e-03	-6.88	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	28	16828	49	FBXL7,NHSL1,AQP4,ADCY2,LSAMP,FMN2,NTRK2,GLIS3,FGFR3,PARD3B,CTNND2,SORBS1,RYR3,RORA,GLI3,GPM6A,GABRB1,PAMR1,PREX2,SLC1A3,ZNRF3,SPARCL1,SLC1A2,NKAIN3,SOX5,MACF1,NPAS3,GPC5
1.034e-03	-6.87	response to endogenous stimulus	biological process	GO:0009719	1402	11	18204	49	NTRK2,BMPR1B,RYR3,SORBS1,ATP1A2,SLC1A2,SLC1A3,FGFR3,GNA14,SOX5,GABRB1
1.043e-03	-6.87	synapse	cellular component	GO:0045202	1473	11	19108	49	NTRK2,CTNND2,ATP1A2,SLC1A2,GABRB1,TNIK,STON2,SPARCL1,GPM6A,SLC1A3,DTNA
1.063e-03	-6.85	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	2	18521	50	ATP1A2,ATP13A4
1.066e-03	-6.84	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	7	16828	49	FBXL7,NTRK2,CACHD1,SLC4A4,ADCY2,CTNND2,RYR3
1.071e-03	-6.84	astrocyte projection	cellular component	GO:0097449	19	2	19108	49	AQP4,SLC1A2
1.089e-03	-6.82	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	7	16828	49	RYR3,CTNND2,ADCY2,CACHD1,FBXL7,NTRK2,SLC4A4
1.105e-03	-6.81	Cation_ATPase_N	pfam domains	PF00690	18	2	17795	49	ATP13A4,ATP1A2
1.158e-03	-6.76	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	6	18204	49	SLC1A3,CTNND2,GLI3,CTNNA2,BMPR1B,PREX2
1.165e-03	-6.76	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	49	16828	49	ATP13A4,RYR3,GLIS3,FMN2,GNA14,PARD3B,SHROOM3,ADCY2,AQP4,PITPNC1,NPAS3,ATP1A2,BMPR1B,RANBP3L,PAMR1,SLC1A3,GPM6A,STON2,CTNND2,SORBS1,CPE,NTRK2,ABLIM1,FGFR3,HIF3A,NHSL1,MGAT4C,LSAMP,SFXN5,GLUD1,FBXL7,TNIK,MSI2,GPC5,SLC4A4,CACHD1,NKAIN3,MACF1,SOX5,NTM,ZNRF3,SPARCL1,PREX2,SLC1A2,RORA,DTNA,GLI3,GABRB1,RFX4
1.179e-03	-6.74	cartilage condensation	biological process	GO:0001502	19	2	18204	49	SOX5,BMPR1B
1.186e-03	-6.74	PAS_fold	interpro domains	IPR013767	19	2	18521	50	NPAS3,HIF3A
1.196e-03	-6.73	cartilage development	biological process	GO:0051216	173	4	18204	49	BMPR1B,FGFR3,GLI3,SOX5
1.210e-03	-6.72	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	49	SLC1A3,SLC1A2,NTRK2
1.222e-03	-6.71	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	9	16828	49	ADCY2,PREX2,ATP13A4,MGAT4C,CTNND2,SORBS1,GLI3,MACF1,GABRB1
1.233e-03	-6.70	PAS	pfam domains	PF00989	19	2	17795	49	HIF3A,NPAS3
1.246e-03	-6.69	somatodendritic compartment	cellular component	GO:0036477	842	8	19108	49	BMPR1B,ADCY2,SLC1A3,GPM6A,CTNND2,NTRK2,ATP1A2,GABRB1
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC4A4,SLC1A3,SLC1A2
1.253e-03	-6.68	Endochondral Ossification	WikiPathways	WP474	65	3	5310	18	FGFR3,SOX5,GLI3
1.293e-03	-6.65	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	3	18094	48	NTRK2,FGFR3,BMPR1B
1.307e-03	-6.64	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	49	SLC1A3,SLC1A2
1.317e-03	-6.63	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	45	16828	49	STON2,CTNND2,SORBS1,CPE,NTRK2,ABLIM1,FGFR3,HIF3A,NHSL1,MGAT4C,LSAMP,SFXN5,GLUD1,FBXL7,TNIK,GPC5,CACHD1,NKAIN3,SOX5,MACF1,NTM,SPARCL1,PREX2,SLC1A2,RORA,GLI3,GABRB1,RFX4,ATP13A4,RYR3,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,ADCY2,AQP4,PITPNC1,NPAS3,ATP1A2,BMPR1B,RANBP3L,PAMR1,SLC1A3,GPM6A
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	MACF1,SORBS1
1.332e-03	-6.62	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	14	16828	49	CPE,ATP1A2,FMN2,BMPR1B,ABLIM1,FGFR3,ATP13A4,CTNND2,SORBS1,RORA,GABRB1,SPARCL1,PREX2,MGAT4C
1.332e-03	-6.62	mucosal	COSMIC cancer mutations	mucosal	2009	14	16828	49	SPARCL1,PREX2,MGAT4C,RORA,GABRB1,ATP13A4,SORBS1,CTNND2,ATP1A2,CPE,FMN2,BMPR1B,ABLIM1,FGFR3
1.383e-03	-6.58	trunk	COSMIC cancer mutations	trunk	3554	20	16828	49	RYR3,CTNND2,NPAS3,ATP13A4,STON2,ABLIM1,FGFR3,ATP1A2,GLIS3,NTRK2,CACHD1,CPE,SOX5,MACF1,LSAMP,HIF3A,SPARCL1,PREX2,SLC1A3,MGAT4C
1.443e-03	-6.54	cell aggregation	biological process	GO:0098743	21	2	18204	49	SOX5,BMPR1B
1.465e-03	-6.53	Cation_ATPase_N	smart domains	SM00831	16	2	9717	35	ATP1A2,ATP13A4
1.474e-03	-6.52	monoatomic cation transmembrane transport	biological process	GO:0098655	636	7	18204	49	GPM6A,SLC4A4,ATP13A4,ATP1A2,CACHD1,SLC1A3,RYR3
1.489e-03	-6.51	localization	biological process	GO:0051179	4474	22	18204	49	TNIK,SFXN5,CPE,AQP4,GPM6A,SLC4A4,PITPNC1,ATP13A4,NTRK2,SLC1A2,CACHD1,ATP1A2,RYR3,MACF1,SHROOM3,STON2,PARD3B,SLC1A3,GLI3,GABRB1,FMN2,RANBP3L
1.548e-03	-6.47	SFN (stratifin)	protein interactions	2810	671	7	19454	50	FMN2,PARD3B,SHROOM3,ABLIM1,TNIK,SORBS1,MACF1
1.563e-03	-6.46	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	42	16828	49	SFXN5,FBXL7,TNIK,MSI2,NHSL1,ADCY2,HIF3A,LSAMP,FMN2,CPE,NTRK2,GLIS3,FGFR3,SHROOM3,PARD3B,GNA14,ABLIM1,STON2,ATP13A4,CTNND2,RYR3,RORA,GLI3,DTNA,RFX4,GABRB1,PAMR1,SLC1A3,PREX2,SPARCL1,SLC1A2,BMPR1B,NKAIN3,SOX5,MACF1,CACHD1,ATP1A2,NTM,RANBP3L,NPAS3,SLC4A4,GPC5
1.584e-03	-6.45	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	49	SLC1A3,ATP1A2
1.594e-03	-6.44	DEP_dom	interpro domains	IPR000591	22	2	18521	50	PREX2,FMN2
1.595e-03	-6.44	establishment of localization	biological process	GO:0051234	3887	20	18204	49	STON2,RANBP3L,MACF1,ATP1A2,CACHD1,RYR3,SLC1A2,SLC4A4,PITPNC1,ATP13A4,NTRK2,GPM6A,FMN2,AQP4,GLI3,GABRB1,CPE,SLC1A3,SFXN5,PARD3B
1.604e-03	-6.44	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	3	19454	50	DTNA,CACHD1,FMN2
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A2,SLC1A3
1.707e-03	-6.37	response to organic cyclic compound	biological process	GO:0014070	843	8	18204	49	GABRB1,GNA14,RORA,SLC1A2,ADCY2,ATP1A2,SLC1A3,RYR3
1.715e-03	-6.37	human chr5p13.2	chromosome location	human chr5p13.2	32	2	26134	50	RANBP3L,SLC1A3
1.728e-03	-6.36	transport	biological process	GO:0006810	3615	19	18204	49	RANBP3L,STON2,MACF1,RYR3,CACHD1,ATP1A2,SLC1A2,ATP13A4,NTRK2,SLC4A4,PITPNC1,GPM6A,AQP4,FMN2,GABRB1,GLI3,CPE,SLC1A3,SFXN5
1.740e-03	-6.35	middle_lobe	COSMIC cancer mutations	middle_lobe	1382	11	16828	49	CACHD1,CPE,ATP1A2,MACF1,FGFR3,PARD3B,SHROOM3,STON2,ATP13A4,RYR3,CTNND2
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	ATP1A2,DTNA,GLUD1,RYR3
1.758e-03	-6.34	cell development	biological process	GO:0048468	2236	14	18204	49	MSI2,PREX2,GPM6A,CTNNA2,NTRK2,BMPR1B,CTNND2,TNIK,SLC1A3,NTM,GABRB1,GLI3,FMN2,RORA
1.826e-03	-6.31	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	5	16828	49	SHROOM3,FGFR3,GLIS3,MGAT4C,MACF1
1.828e-03	-6.30	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	4	5310	18	NTRK2,SLC1A3,RORA,AQP4
1.832e-03	-6.30	P-type ion transporter activity	molecular function	GO:0015662	24	2	18094	48	ATP1A2,ATP13A4
1.832e-03	-6.30	P-type transmembrane transporter activity	molecular function	GO:0140358	24	2	18094	48	ATP1A2,ATP13A4
1.856e-03	-6.29	bone development	biological process	GO:0060348	195	4	18204	49	RANBP3L,FGFR3,GLI3,BMPR1B
1.909e-03	-6.26	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	12	16828	49	ABLIM1,FGFR3,PARD3B,CPE,RORA,FMN2,MACF1,DTNA,GLI3,CTNND2,SORBS1,PREX2
1.909e-03	-6.26	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	12	16828	49	PREX2,GLI3,DTNA,RORA,SORBS1,CTNND2,ABLIM1,PARD3B,FGFR3,CPE,MACF1,FMN2
1.911e-03	-6.26	cell-cell junction	cellular component	GO:0005911	513	6	19108	49	SORBS1,SHROOM3,CTNND2,ATP1A2,PARD3B,CTNNA2
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr12q21.31-q21.32	chromosome location	human chr12q21.31-q21.32	1	1	26134	50	MGAT4C
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.920e-03	-6.26	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	28	16828	49	MACF1,ATP1A2,CACHD1,SLC4A4,GPC5,GLI3,DTNA,GPM6A,RFX4,GABRB1,PREX2,SLC1A3,SPARCL1,FMN2,NTRK2,GLIS3,PARD3B,SHROOM3,FGFR3,ABLIM1,GNA14,ATP13A4,STON2,SORBS1,SFXN5,MGAT4C,HIF3A,ADCY2
1.931e-03	-6.25	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	28	16828	49	SLC1A3,PREX2,SPARCL1,RFX4,GABRB1,GLI3,DTNA,GPM6A,SLC4A4,GPC5,MACF1,CACHD1,ATP1A2,MGAT4C,ADCY2,HIF3A,SFXN5,SORBS1,STON2,ATP13A4,FGFR3,SHROOM3,PARD3B,GNA14,ABLIM1,FMN2,NTRK2,GLIS3
2.021e-03	-6.20	skin-face-malignant_melanoma-lentigo_maligna	COSMIC cancer mutations	skin-face-malignant_melanoma-lentigo_maligna	23	2	16828	49	PREX2,FGFR3
2.023e-03	-6.20	NRCAM (neuronal cell adhesion molecule)	protein interactions	4897	26	2	19454	50	MACF1,GLUD1
2.045e-03	-6.19	actin cytoskeleton	cellular component	GO:0015629	520	6	19108	49	SORBS1,CTNNA2,ABLIM1,MACF1,SHROOM3,FMN2
2.047e-03	-6.19	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	3	19454	50	FGFR3,NTRK2,SORBS1
2.047e-03	-6.19	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	49	SLC1A2,SLC1A3
2.118e-03	-6.16	regulation of Wnt signaling pathway	biological process	GO:0030111	339	5	18204	49	CTNND2,GLI3,GPC5,ZNRF3,MACF1
2.139e-03	-6.15	scalp	COSMIC cancer mutations	scalp	2110	14	16828	49	GPC5,SLC4A4,ATP13A4,SORBS1,ATP1A2,MACF1,SOX5,FMN2,SHROOM3,FGFR3,NTM,PREX2,LSAMP,RORA
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	CTNNA2,GNA14,DTNA
2.181e-03	-6.13	HPCAL4 (hippocalcin like 4)	protein interactions	51440	27	2	19454	50	GPM6A,AQP4
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	DTNA,ABLIM1
2.181e-03	-6.13	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	30	SLC1A2,SLC1A3
2.214e-03	-6.11	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	49	SLC1A3,SLC1A2
2.250e-03	-6.10	cellular response to organonitrogen compound	biological process	GO:0071417	505	6	18204	49	GABRB1,GNA14,SORBS1,SLC1A3,RYR3,SLC1A2
2.341e-03	-6.06	actin filament binding	molecular function	GO:0051015	211	4	18094	48	ABLIM1,MACF1,CTNNA2,SHROOM3
2.362e-03	-6.05	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	48	16828	49	GPM6A,SLC1A3,PAMR1,ATP1A2,BMPR1B,RANBP3L,NPAS3,ADCY2,PITPNC1,AQP4,GLIS3,FMN2,GNA14,PARD3B,SHROOM3,ATP13A4,RYR3,GLI3,DTNA,RORA,GABRB1,RFX4,ZNRF3,SPARCL1,PREX2,SLC1A2,CACHD1,SOX5,MACF1,NKAIN3,NTM,GPC5,SLC4A4,GLUD1,FBXL7,SFXN5,TNIK,HIF3A,MGAT4C,NHSL1,LSAMP,NTRK2,CPE,ABLIM1,FGFR3,STON2,SORBS1,CTNND2
2.398e-03	-6.03	bone morphogenesis	biological process	GO:0060349	99	3	18204	49	GLI3,FGFR3,BMPR1B
2.401e-03	-6.03	neuron projection development	biological process	GO:0031175	693	7	18204	49	GLI3,TNIK,CTNND2,CTNNA2,BMPR1B,PREX2,GPM6A
2.424e-03	-6.02	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	3	19454	50	SORBS1,ABLIM1,SPARCL1
2.467e-03	-6.00	response to alkaloid	biological process	GO:0043279	100	3	18204	49	SLC1A3,RYR3,SLC1A2
2.487e-03	-6.00	Salivary secretion	KEGG pathways	hsa04970	90	3	7161	22	ADCY2,RYR3,ATP1A2
2.487e-03	-6.00	Salivary secretion	KEGG pathways	ko04970	90	3	7161	22	ADCY2,RYR3,ATP1A2
2.535e-03	-5.98	signaling	biological process	GO:0023052	4968	23	18204	49	BMPR1B,PREX2,ZNRF3,SORBS1,CTNND2,SPARCL1,SLC1A3,FGFR3,RORA,FMN2,GABRB1,GLI3,NTRK2,PITPNC1,RYR3,ATP1A2,SLC1A2,MACF1,DTNA,ADCY2,TNIK,CPE,GNA14
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	fgf3.L (fibroblast growth factor 3 L homeolog)	protein interactions	373669	1	1	19454	50	FGFR3
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Sh2b1 (SH2B adaptor protein 1)	protein interactions	20399	1	1	19454	50	FGFR3
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.593e-03	-5.95	Calcium-transporting ATPase, transmembrane domain	gene3d domains	1.20.1110.10	25	2	14470	44	ATP13A4,ATP1A2
2.626e-03	-5.94	embryonal	COSMIC cancer mutations	embryonal	2659	16	16828	49	RORA,GLI3,ZNRF3,ADCY2,SPARCL1,AQP4,PREX2,FGFR3,PARD3B,GLIS3,FMN2,MACF1,RYR3,CTNND2,SORBS1,NPAS3
2.626e-03	-5.94	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	16	16828	49	RORA,GLI3,ZNRF3,SPARCL1,ADCY2,AQP4,PREX2,FGFR3,PARD3B,GLIS3,FMN2,MACF1,RYR3,CTNND2,SORBS1,NPAS3
2.653e-03	-5.93	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	48	NTRK2
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A3,SLC1A2
2.692e-03	-5.92	lateral ganglionic eminence cell proliferation	biological process	GO:0022018	1	1	18204	49	GLI3
2.692e-03	-5.92	subpallium cell proliferation in forebrain	biological process	GO:0022012	1	1	18204	49	GLI3
2.692e-03	-5.92	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	49	NTRK2
2.692e-03	-5.92	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	49	FMN2
2.692e-03	-5.92	lambdoid suture morphogenesis	biological process	GO:0060366	1	1	18204	49	GLI3
2.692e-03	-5.92	anterior semicircular canal development	biological process	GO:0060873	1	1	18204	49	GLI3
2.692e-03	-5.92	olfactory cortex development	biological process	GO:0021989	1	1	18204	49	ATP1A2
2.692e-03	-5.92	sagittal suture morphogenesis	biological process	GO:0060367	1	1	18204	49	GLI3
2.692e-03	-5.92	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	49	ATP1A2
2.692e-03	-5.92	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	49	NTRK2
2.692e-03	-5.92	lateral semicircular canal development	biological process	GO:0060875	1	1	18204	49	GLI3
2.700e-03	-5.91	Stonin2_N	interpro domains	IPR022699	1	1	18521	50	STON2
2.700e-03	-5.91	Sensor-like_sf	interpro domains	IPR029151	1	1	18521	50	CACHD1
2.700e-03	-5.91	M14_CPE_CPD	interpro domains	IPR034232	1	1	18521	50	CPE
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	ZNRF3_Znf_RING	interpro domains	IPR045903	1	1	18521	50	ZNRF3
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	STON2_MHD	interpro domains	IPR031228	1	1	18521	50	STON2
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	TNIK,SFXN5,FBXL7,GLUD1,LSAMP,NHSL1,MGAT4C,HIF3A,FGFR3,ABLIM1,CPE,NTRK2,CTNND2,SORBS1,STON2,RFX4,GABRB1,RORA,GLI3,DTNA,SLC1A2,PREX2,ZNRF3,SPARCL1,NTM,NKAIN3,SOX5,MACF1,CACHD1,SLC4A4,GPC5,AQP4,PITPNC1,ADCY2,PARD3B,SHROOM3,GNA14,FMN2,GLIS3,RYR3,ATP13A4,GPM6A,PAMR1,SLC1A3,RANBP3L,BMPR1B,ATP1A2,NPAS3
2.754e-03	-5.89	Stonin2_N	pfam domains	PF12016	1	1	17795	49	STON2
2.754e-03	-5.89	FGFR3_TM	pfam domains	PF21165	1	1	17795	49	FGFR3
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	STON2,SORBS1,CTNND2,NTRK2,CPE,FGFR3,ABLIM1,MGAT4C,NHSL1,HIF3A,LSAMP,FBXL7,GLUD1,SFXN5,TNIK,SLC4A4,GPC5,SOX5,MACF1,NKAIN3,CACHD1,NTM,PREX2,ZNRF3,SPARCL1,SLC1A2,GLI3,DTNA,RORA,RFX4,GABRB1,ATP13A4,RYR3,FMN2,GLIS3,SHROOM3,PARD3B,GNA14,PITPNC1,AQP4,ADCY2,NPAS3,BMPR1B,ATP1A2,RANBP3L,SLC1A3,PAMR1,GPM6A
2.834e-03	-5.87	neural precursor cell proliferation	biological process	GO:0061351	105	3	18204	49	RORA,SOX5,GLI3
2.853e-03	-5.86	cell communication	biological process	GO:0007154	5010	23	18204	49	CPE,FMN2,RORA,GABRB1,GLI3,GNA14,SPARCL1,SLC1A3,TNIK,FGFR3,ADCY2,DTNA,MACF1,CTNND2,PITPNC1,BMPR1B,NTRK2,PREX2,ATP1A2,ZNRF3,RYR3,SORBS1,SLC1A2
2.857e-03	-5.86	cell body	cellular component	GO:0044297	556	6	19108	49	GPM6A,BMPR1B,SLC1A3,CTNND2,SLC1A2,ATP1A2
2.859e-03	-5.86	inorganic ion transmembrane transport	biological process	GO:0098660	715	7	18204	49	ATP1A2,CACHD1,SLC1A3,RYR3,GPM6A,SLC4A4,GABRB1
2.870e-03	-5.85	SH2B1 (SH2B adaptor protein 1)	protein interactions	25970	31	2	19454	50	NTRK2,FGFR3
2.901e-03	-5.84	Pancreatic secretion	KEGG pathways	hsa04972	95	3	7161	22	ADCY2,SLC4A4,ATP1A2
2.901e-03	-5.84	Pancreatic secretion	KEGG pathways	ko04972	95	3	7161	22	ATP1A2,SLC4A4,ADCY2
2.917e-03	-5.84	t(4;14) translocations of FGFR3	REACTOME pathways	R-HSA-2033515	1	1	10285	30	FGFR3
2.942e-03	-5.83	L-glutamate import	biological process	GO:0051938	30	2	18204	49	SLC1A2,SLC1A3
2.993e-03	-5.81	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	8	19454	50	FGFR3,PARD3B,NHSL1,SORBS1,PITPNC1,SHROOM3,MACF1,ABLIM1
3.000e-03	-5.81	Ion channel transport	REACTOME pathways	R-HSA-983712	209	4	10285	30	ATP1A2,RYR3,ATP13A4,GABRB1
3.041e-03	-5.80	-	gene3d domains	6.10.250.1740	1	1	14470	44	FGFR3
3.042e-03	-5.80	presynaptic active zone membrane	cellular component	GO:0048787	32	2	19108	49	GABRB1,GPM6A
3.055e-03	-5.79	CDH1 (cadherin 1)	protein interactions	999	757	7	19454	50	ABLIM1,MACF1,CTNND2,SHROOM3,SORBS1,CTNNA2,NHSL1
3.072e-03	-5.79	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	11	16828	49	DTNA,MACF1,FMN2,PARD3B,FGFR3,GABRB1,PREX2,NPAS3,GPC5,SORBS1,RYR3
3.132e-03	-5.77	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	14	16828	49	TNIK,GLI3,DTNA,ADCY2,PREX2,FGFR3,PARD3B,SHROOM3,CACHD1,NTRK2,ATP1A2,BMPR1B,SOX5,SLC4A4
3.202e-03	-5.74	presynapse	cellular component	GO:0098793	569	6	19108	49	STON2,TNIK,NTRK2,GPM6A,GABRB1,SLC1A2
3.224e-03	-5.74	human chr11p13	chromosome location	human chr11p13	44	2	26134	50	PAMR1,SLC1A2
3.261e-03	-5.73	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	9	18204	49	CTNND2,GLI3,TNIK,CTNNA2,RFX4,BMPR1B,PREX2,ABLIM1,GPM6A
3.266e-03	-5.72	skeletal system morphogenesis	biological process	GO:0048705	228	4	18204	49	BMPR1B,SOX5,FGFR3,GLI3
3.282e-03	-5.72	E1-E2_ATPase	pfam domains	PF00122	31	2	17795	49	ATP13A4,ATP1A2
3.344e-03	-5.70	transepithelial transport	biological process	GO:0070633	32	2	18204	49	SLC1A2,SLC1A3
3.430e-03	-5.68	skin-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-malignant_melanoma-acral_lentiginous	30	2	16828	49	PREX2,FGFR3
3.430e-03	-5.68	lentigo_maligna	COSMIC cancer mutations	lentigo_maligna	30	2	16828	49	FGFR3,PREX2
3.434e-03	-5.67	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	4	10285	30	ADCY2,GABRB1,SLC1A3,SLC1A2
3.476e-03	-5.66	connective tissue development	biological process	GO:0061448	232	4	18204	49	SOX5,GLI3,FGFR3,BMPR1B
3.480e-03	-5.66	organic substance transport	biological process	GO:0071702	1881	12	18204	49	SLC1A3,SFXN5,CPE,FMN2,GLI3,PITPNC1,SLC4A4,NTRK2,ATP13A4,SLC1A2,MACF1,RANBP3L
3.486e-03	-5.66	dendrite development	biological process	GO:0016358	113	3	18204	49	CTNND2,CTNNA2,PREX2
3.495e-03	-5.66	Cation_ATPase	pfam domains	PF13246	32	2	17795	49	ATP13A4,ATP1A2
3.553e-03	-5.64	response to auditory stimulus	biological process	GO:0010996	33	2	18204	49	SLC1A3,ATP1A2
3.590e-03	-5.63	PAS	smart domains	SM00091	25	2	9717	35	HIF3A,NPAS3
3.602e-03	-5.63	DELLA	smart domains	SM01129	1	1	9717	35	MACF1
3.624e-03	-5.62	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	3	10285	30	SLC4A4,SLC1A2,SLC1A3
3.624e-03	-5.62	upper_leg	COSMIC cancer mutations	upper_leg	880	8	16828	49	PREX2,STON2,PAMR1,HIF3A,SHROOM3,FGFR3,FMN2,GLIS3
3.656e-03	-5.61	thyroid-carcinoma	COSMIC cancer mutations	thyroid-carcinoma	4126	21	16828	49	GPC5,ATP13A4,STON2,RYR3,CTNND2,GLIS3,ATP1A2,CACHD1,CPE,MACF1,SOX5,SHROOM3,FGFR3,HIF3A,ZNRF3,ADCY2,SPARCL1,AQP4,LSAMP,DTNA,TNIK
3.688e-03	-5.60	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	3	18094	48	SLC1A2,SLC4A4,SLC1A3
3.688e-03	-5.60	calcium channel activity	molecular function	GO:0005262	117	3	18094	48	GPM6A,CACHD1,RYR3
3.792e-03	-5.57	PAS	interpro domains	IPR000014	34	2	18521	50	HIF3A,NPAS3
3.792e-03	-5.57	PAS-like_dom_sf	interpro domains	IPR035965	34	2	18521	50	NPAS3,HIF3A
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A2,SLC1A3
3.912e-03	-5.54	Ig_sub2	interpro domains	IPR003598	239	4	18521	50	FGFR3,LSAMP,NTM,NTRK2
3.969e-03	-5.53	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	4	19454	50	TNIK,SORBS1,NHSL1,NTRK2
3.978e-03	-5.53	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	5	16828	49	CTNND2,SHROOM3,PREX2,MACF1,CPE
4.018e-03	-5.52	AQUAPORIN4	prints domains	PR02016	1	1	5227	21	AQP4
4.018e-03	-5.52	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	21	NTRK2
4.052e-03	-5.51	glial cell projection	cellular component	GO:0097386	37	2	19108	49	AQP4,SLC1A2
4.127e-03	-5.49	striated muscle contraction	biological process	GO:0006941	120	3	18204	49	RYR3,ATP1A2,DTNA
4.183e-03	-5.48	monoatomic cation transport	biological process	GO:0006812	766	7	18204	49	RYR3,SLC1A3,ATP1A2,CACHD1,GPM6A,ATP13A4,SLC4A4
4.217e-03	-5.47	organic anion transport	biological process	GO:0015711	398	5	18204	49	SLC1A2,SFXN5,SLC1A3,SLC4A4,NTRK2
4.244e-03	-5.46	ATPase_P-typ_P_site	interpro domains	IPR018303	36	2	18521	50	ATP13A4,ATP1A2
4.244e-03	-5.46	P_typ_ATPase	interpro domains	IPR001757	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_cyto_dom_N	interpro domains	IPR023299	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	ATPase_P-typ_transduc_dom_A_sf	interpro domains	IPR008250	36	2	18521	50	ATP1A2,ATP13A4
4.244e-03	-5.46	P_typ_ATPase_HD_dom	interpro domains	IPR044492	36	2	18521	50	ATP13A4,ATP1A2
4.258e-03	-5.46	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	3	19454	50	MACF1,ABLIM1,DTNA
4.275e-03	-5.45	cell projection organization	biological process	GO:0030030	1200	9	18204	49	CTNND2,GLI3,TNIK,BMPR1B,RFX4,CTNNA2,ABLIM1,GPM6A,PREX2
4.335e-03	-5.44	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	40	16828	49	RFX4,GABRB1,RORA,GLI3,DTNA,GPM6A,SLC1A2,PAMR1,PREX2,SLC1A3,SPARCL1,RANBP3L,NKAIN3,MACF1,SOX5,CACHD1,ATP1A2,NPAS3,GPC5,TNIK,SFXN5,FBXL7,GLUD1,LSAMP,AQP4,NHSL1,MGAT4C,ADCY2,FGFR3,SHROOM3,ABLIM1,GNA14,FMN2,CPE,NTRK2,CTNND2,SORBS1,RYR3,STON2,ATP13A4
4.451e-03	-5.41	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	49	SORBS1,SLC1A2
4.454e-03	-5.41	cellular response to nitrogen compound	biological process	GO:1901699	580	6	18204	49	SLC1A2,SLC1A3,SORBS1,RYR3,GNA14,GABRB1
4.470e-03	-5.41	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	9	16828	49	SOX5,FMN2,GNA14,GABRB1,ATP13A4,GPC5,ADCY2,SLC1A2,RYR3
4.478e-03	-5.41	ATPase_P-typ_TM_dom_sf	interpro domains	IPR023298	37	2	18521	50	ATP1A2,ATP13A4
4.491e-03	-5.41	intracellular chemical homeostasis	biological process	GO:0055082	581	6	18204	49	SLC4A4,ATP13A4,ATP1A2,SLC1A3,AQP4,RYR3
4.494e-03	-5.41	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	4	19454	50	DTNA,CACHD1,MACF1,FMN2
4.496e-03	-5.40	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	13	16828	49	FGFR3,ABLIM1,FMN2,MACF1,GPC5,MSI2,GABRB1,RORA,GPM6A,LSAMP,AQP4,PREX2,ZNRF3
4.523e-03	-5.40	action potential	biological process	GO:0001508	124	3	18204	49	GNA14,ATP1A2,NTRK2
4.543e-03	-5.39	animal organ morphogenesis	biological process	GO:0009887	988	8	18204	49	SOX5,GLI3,CPE,FGFR3,ABLIM1,NTRK2,BMPR1B,CTNNA2
4.604e-03	-5.38	PDZ	pfam domains	PF00595	122	3	17795	49	PARD3B,SHROOM3,PREX2
4.616e-03	-5.38	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	28	16828	49	BMPR1B,SOX5,MACF1,CACHD1,ATP1A2,NTM,SLC4A4,GPC5,RORA,GLI3,RFX4,GABRB1,PAMR1,PREX2,ZNRF3,FMN2,CPE,NTRK2,FGFR3,SHROOM3,ABLIM1,STON2,ATP13A4,CTNND2,RYR3,TNIK,PITPNC1,ADCY2
4.616e-03	-5.38	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	28	16828	49	PITPNC1,ADCY2,TNIK,STON2,ATP13A4,CTNND2,RYR3,FMN2,CPE,NTRK2,FGFR3,SHROOM3,ABLIM1,PAMR1,PREX2,ZNRF3,RORA,GLI3,RFX4,GABRB1,SLC4A4,GPC5,BMPR1B,MACF1,SOX5,CACHD1,ATP1A2,NTM
4.682e-03	-5.36	forebrain development	biological process	GO:0030900	408	5	18204	49	SLC1A2,GLI3,ATP1A2,RFX4,NTRK2
4.691e-03	-5.36	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	49	SLC1A2,SLC1A3
4.852e-03	-5.33	cellular process	biological process	GO:0009987	14996	47	18204	49	SLC1A3,FGFR3,SPARCL1,PARD3B,FMN2,RORA,GLUD1,GABRB1,GLI3,SOX5,ZNRF3,MSI2,ABLIM1,NTM,RFX4,MGAT4C,GNA14,ATP1A2,CACHD1,SLC1A2,GLIS3,NTRK2,ATP13A4,HIF3A,GPM6A,DTNA,FBXL7,SORBS1,CTNNA2,BMPR1B,PREX2,RANBP3L,GPC5,CTNND2,TNIK,SFXN5,ADCY2,AQP4,CPE,RYR3,PITPNC1,SLC4A4,STON2,NHSL1,SHROOM3,LSAMP,MACF1
4.853e-03	-5.33	Glutamatergic synapse	KEGG pathways	hsa04724	114	3	7161	22	SLC1A2,ADCY2,SLC1A3
4.853e-03	-5.33	Glutamatergic synapse	KEGG pathways	ko04724	114	3	7161	22	SLC1A3,ADCY2,SLC1A2
4.918e-03	-5.31	cell differentiation	biological process	GO:0030154	3645	18	18204	49	RANBP3L,NHSL1,CTNND2,MSI2,CTNNA2,NTRK2,BMPR1B,PREX2,GPM6A,FMN2,RORA,GABRB1,GLI3,SOX5,NTM,SLC1A3,FGFR3,TNIK
4.936e-03	-5.31	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	49	ATP1A2,SLC1A3
4.945e-03	-5.31	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	3	19454	50	CPE,NTM,GPM6A
4.963e-03	-5.31	cellular developmental process	biological process	GO:0048869	3648	18	18204	49	RORA,FMN2,SOX5,GABRB1,GLI3,SLC1A3,NTM,FGFR3,TNIK,NHSL1,RANBP3L,CTNND2,MSI2,NTRK2,BMPR1B,CTNNA2,GPM6A,PREX2
4.975e-03	-5.30	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	40	16828	49	RYR3,SORBS1,CTNND2,ATP13A4,GNA14,SHROOM3,PARD3B,FGFR3,GLIS3,NTRK2,CPE,FMN2,LSAMP,ADCY2,MGAT4C,NHSL1,MSI2,TNIK,GLUD1,FBXL7,SFXN5,GPC5,NPAS3,SLC4A4,RANBP3L,NTM,ATP1A2,CACHD1,MACF1,SOX5,BMPR1B,SLC1A2,ZNRF3,PREX2,SLC1A3,PAMR1,GABRB1,GLI3,DTNA,RORA
5.049e-03	-5.29	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	3	19454	50	ABLIM1,DTNA,NTRK2
5.090e-03	-5.28	cation binding	molecular function	GO:0043169	4341	20	18094	48	ZNRF3,ATP13A4,CPE,PAMR1,GLUD1,BMPR1B,SLC1A3,DTNA,ADCY2,ATP1A2,MACF1,SLC1A2,GLI3,RORA,SPARCL1,GNA14,MGAT4C,GLIS3,RYR3,ABLIM1
5.127e-03	-5.27	EF-hand-dom_pair	interpro domains	IPR011992	258	4	18521	50	MACF1,SPARCL1,DTNA,RYR3
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.157e-03	-5.27	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	8	16828	49	BMPR1B,MACF1,NTRK2,ATP1A2,TNIK,FGFR3,STON2,PREX2
5.187e-03	-5.26	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	2	18204	49	ADCY2,RORA
5.198e-03	-5.26	PAS	prosite domains	PS50112	30	2	12186	44	HIF3A,NPAS3
5.299e-03	-5.24	glutamate dehydrogenase (NADP+) activity	molecular function	GO:0004354	2	1	18094	48	GLUD1
5.299e-03	-5.24	G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	molecular function	GO:0150047	2	1	18094	48	GABRB1
5.299e-03	-5.24	glutamate dehydrogenase [NAD(P)+] activity	molecular function	GO:0004353	2	1	18094	48	GLUD1
5.299e-03	-5.24	glutamate dehydrogenase (NAD+) activity	molecular function	GO:0004352	2	1	18094	48	GLUD1
5.299e-03	-5.24	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	molecular function	GO:0016639	2	1	18094	48	GLUD1
5.312e-03	-5.24	SYNE3 (spectrin repeat containing nuclear envelope family member 3)	protein interactions	161176	440	5	19454	50	SHROOM3,ABLIM1,SORBS1,MACF1,GLI3
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic transduction domain A	gene3d domains	2.70.150.10	36	2	14470	44	ATP1A2,ATP13A4
5.331e-03	-5.23	Calcium-transporting ATPase, cytoplasmic domain N	gene3d domains	3.40.1110.10	36	2	14470	44	ATP1A2,ATP13A4
5.356e-03	-5.23	lung-middle_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-middle_lobe-carcinoma-adenocarcinoma	1368	10	16828	49	CPE,CACHD1,ATP1A2,MACF1,PARD3B,SHROOM3,STON2,ATP13A4,RYR3,CTNND2
5.376e-03	-5.23	larynx development	biological process	GO:0120224	2	1	18204	49	GLI3
5.376e-03	-5.23	fibroblast growth factor receptor apoptotic signaling pathway	biological process	GO:1902178	2	1	18204	49	FGFR3
5.376e-03	-5.23	mesenchymal cell differentiation involved in bone development	biological process	GO:1901706	2	1	18204	49	RANBP3L
5.376e-03	-5.23	Wnt receptor catabolic process	biological process	GO:0038018	2	1	18204	49	ZNRF3
5.376e-03	-5.23	larynx morphogenesis	biological process	GO:0120223	2	1	18204	49	GLI3
5.376e-03	-5.23	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	biological process	GO:0021776	2	1	18204	49	GLI3
5.376e-03	-5.23	mammary gland specification	biological process	GO:0060594	2	1	18204	49	GLI3
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	Glu/Leu/Phe/Val/Trp_DH_dimer	interpro domains	IPR006097	2	1	18521	50	GLUD1
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Glu/Leu/Phe/Val_DH_AS	interpro domains	IPR033524	2	1	18521	50	GLUD1
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	NAD_bind_Glu_DH	interpro domains	IPR033922	2	1	18521	50	GLUD1
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	Glu/Leu/Phe/Val/Trp_DH_C	interpro domains	IPR006096	2	1	18521	50	GLUD1
5.392e-03	-5.22	Par3/HAL_N	interpro domains	IPR021922	2	1	18521	50	PARD3B
5.392e-03	-5.22	ZNRF-3_ecto	interpro domains	IPR040700	2	1	18521	50	ZNRF3
5.392e-03	-5.22	Glu/Leu/Phe/Val/Trp_DH	interpro domains	IPR006095	2	1	18521	50	GLUD1
5.443e-03	-5.21	cyclic nucleotide metabolic process	biological process	GO:0009187	41	2	18204	49	ADCY2,RORA
5.462e-03	-5.21	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	49	16828	49	CPE,NTRK2,ABLIM1,FGFR3,STON2,CTNND2,SORBS1,SFXN5,GLUD1,FBXL7,TNIK,MSI2,HIF3A,NHSL1,MGAT4C,LSAMP,CACHD1,NKAIN3,SOX5,MACF1,NTM,GPC5,SLC4A4,RORA,GLI3,DTNA,GABRB1,RFX4,ZNRF3,SPARCL1,PREX2,SLC1A2,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,ATP13A4,RYR3,ADCY2,AQP4,PITPNC1,ATP1A2,BMPR1B,RANBP3L,NPAS3,GPM6A,PAMR1,SLC1A3
5.492e-03	-5.20	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	4	18094	48	SLC4A4,SFXN5,SLC1A3,SLC1A2
5.493e-03	-5.20	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	3	17795	49	FGFR3,NTRK2,BMPR1B
5.500e-03	-5.20	ZNRF_3_ecto	pfam domains	PF18212	2	1	17795	49	ZNRF3
5.500e-03	-5.20	Par3_HAL_N_term	pfam domains	PF12053	2	1	17795	49	PARD3B
5.500e-03	-5.20	ELFV_dehydrog	pfam domains	PF00208	2	1	17795	49	GLUD1
5.500e-03	-5.20	ELFV_dehydrog_N	pfam domains	PF02812	2	1	17795	49	GLUD1
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A3,SLC1A2
5.547e-03	-5.19	Ser-Thr/Tyr_kinase_cat_dom	interpro domains	IPR001245	133	3	18521	50	NTRK2,BMPR1B,FGFR3
5.565e-03	-5.19	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	4	18204	49	GLI3,GPC5,CTNND2,ZNRF3
5.612e-03	-5.18	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	3	18094	48	RYR3,CACHD1,GPM6A
5.625e-03	-5.18	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	7	16828	49	RANBP3L,DTNA,SOX5,NTRK2,CTNND2,SLC1A3,STON2
5.721e-03	-5.16	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	5	18204	49	SLC4A4,ATP13A4,ATP1A2,RYR3,SLC1A3
5.755e-03	-5.16	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	47	16828	49	FGFR3,ABLIM1,NTRK2,CPE,SORBS1,CTNND2,STON2,MSI2,TNIK,FBXL7,GLUD1,SFXN5,LSAMP,MGAT4C,NHSL1,HIF3A,MACF1,SOX5,NKAIN3,CACHD1,SLC4A4,GPC5,GABRB1,DTNA,GLI3,RORA,SLC1A2,PREX2,ZNRF3,SPARCL1,PARD3B,SHROOM3,GNA14,FMN2,GLIS3,RYR3,ATP13A4,PITPNC1,AQP4,ADCY2,RANBP3L,BMPR1B,ATP1A2,NPAS3,GPM6A,SLC1A3,PAMR1
5.755e-03	-5.16	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	47	16828	49	BMPR1B,ATP1A2,RANBP3L,NPAS3,GPM6A,PAMR1,SLC1A3,FMN2,GLIS3,SHROOM3,PARD3B,GNA14,ATP13A4,RYR3,AQP4,PITPNC1,ADCY2,NKAIN3,SOX5,MACF1,CACHD1,SLC4A4,GPC5,RORA,DTNA,GLI3,GABRB1,PREX2,ZNRF3,SPARCL1,SLC1A2,CPE,NTRK2,FGFR3,ABLIM1,STON2,CTNND2,SORBS1,SFXN5,GLUD1,FBXL7,TNIK,MSI2,NHSL1,MGAT4C,HIF3A,LSAMP
5.890e-03	-5.13	trans-synaptic signaling	biological process	GO:0099537	431	5	18204	49	SLC1A2,GABRB1,SLC1A3,DTNA,NTRK2
5.929e-03	-5.13	postsynapse	cellular component	GO:0098794	646	6	19108	49	GPM6A,TNIK,GABRB1,ATP1A2,CTNND2,NTRK2
5.941e-03	-5.13	rhythmic process	biological process	GO:0048511	270	4	18204	49	BMPR1B,NTRK2,RORA,GABRB1
6.001e-03	-5.12	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	8	19454	50	MACF1,ABLIM1,SORBS1,PITPNC1,SHROOM3,PARD3B,NHSL1,FMN2
6.037e-03	-5.11	Calml3 (calmodulin-like 3)	protein interactions	70405	144	3	19454	50	ABLIM1,MACF1,STON2
6.044e-03	-5.11	inorganic cation transmembrane transport	biological process	GO:0098662	618	6	18204	49	GPM6A,SLC4A4,RYR3,SLC1A3,CACHD1,ATP1A2
6.073e-03	-5.10	-	gene3d domains	1.10.287.140	2	1	14470	44	GLUD1
6.073e-03	-5.10	-	gene3d domains	6.20.350.10	2	1	14470	44	RYR3
6.073e-03	-5.10	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	44	CTNNA2
6.091e-03	-5.10	behavior	biological process	GO:0007610	619	6	18204	49	NTRK2,PREX2,ATP1A2,SLC1A3,GLI3,SLC1A2
6.127e-03	-5.10	cell-cell signaling	biological process	GO:0007267	822	7	18204	49	DTNA,CPE,NTRK2,SLC1A2,GABRB1,FGFR3,SLC1A3
6.164e-03	-5.09	GSK3A (glycogen synthase kinase 3 alpha)	protein interactions	2931	456	5	19454	50	TNIK,MACF1,GLUD1,GLI3,NHSL1
6.174e-03	-5.09	vascular process in circulatory system	biological process	GO:0003018	273	4	18204	49	SLC1A2,SLC1A3,ATP1A2,SLC4A4
6.238e-03	-5.08	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	5	18204	49	SLC4A4,ATP13A4,ATP1A2,SLC1A3,RYR3
6.247e-03	-5.08	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	49	SLC1A2,SORBS1
6.257e-03	-5.07	active transmembrane transporter activity	molecular function	GO:0022804	444	5	18094	48	ATP13A4,SLC1A3,SLC4A4,ATP1A2,SLC1A2
6.281e-03	-5.07	animal organ development	biological process	GO:0048513	2846	15	18204	49	RANBP3L,GPM6A,ABLIM1,NTRK2,BMPR1B,CTNNA2,SLC1A2,ATP1A2,CPE,SOX5,GLI3,RORA,GLUD1,RFX4,FGFR3
6.324e-03	-5.06	monoatomic anion transmembrane transporter activity	molecular function	GO:0008509	142	3	18094	48	SLC4A4,GABRB1,SLC1A2
6.335e-03	-5.06	neurotransmitter transport	biological process	GO:0006836	140	3	18204	49	SLC1A2,SLC1A3,ATP1A2
6.348e-03	-5.06	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	4	19454	50	SORBS1,SHROOM3,FMN2,NHSL1
6.372e-03	-5.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	39	16828	49	GABRB1,RFX4,GLI3,RORA,SLC1A2,SPARCL1,PREX2,SLC1A3,PAMR1,RANBP3L,NTM,ATP1A2,CACHD1,MACF1,SOX5,NKAIN3,GPC5,SLC4A4,NPAS3,MSI2,TNIK,FBXL7,SFXN5,LSAMP,HIF3A,ADCY2,NHSL1,ABLIM1,GNA14,PARD3B,SHROOM3,GLIS3,NTRK2,CPE,FMN2,RYR3,CTNND2,ATP13A4,STON2
6.372e-03	-5.06	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	39	16828	49	GPC5,NPAS3,SLC4A4,RANBP3L,NTM,ATP1A2,CACHD1,SOX5,MACF1,NKAIN3,SLC1A2,SPARCL1,SLC1A3,PREX2,PAMR1,GABRB1,RFX4,GLI3,RORA,RYR3,CTNND2,ATP13A4,STON2,ABLIM1,GNA14,PARD3B,SHROOM3,NTRK2,GLIS3,CPE,FMN2,LSAMP,HIF3A,ADCY2,NHSL1,MSI2,TNIK,FBXL7,SFXN5
6.441e-03	-5.05	membrane raft	cellular component	GO:0045121	290	4	19108	49	ADCY2,SLC1A2,ATP1A2,SORBS1
6.470e-03	-5.04	extrinsic component of cytoplasmic side of plasma membrane	cellular component	GO:0031234	47	2	19108	49	GNA14,DTNA
6.493e-03	-5.04	spleen	COSMIC cancer mutations	spleen	408	5	16828	49	SORBS1,PARD3B,TNIK,NTM,ADCY2
6.500e-03	-5.04	BDNF (brain derived neurotrophic factor)	protein interactions	627	47	2	19454	50	NTRK2,CPE
6.597e-03	-5.02	upper_arm	COSMIC cancer mutations	upper_arm	582	6	16828	49	PREX2,SLC4A4,STON2,FMN2,PARD3B,FGFR3
6.597e-03	-5.02	membrane microdomain	cellular component	GO:0098857	292	4	19108	49	ADCY2,SORBS1,ATP1A2,SLC1A2
6.624e-03	-5.02	metal ion transport	biological process	GO:0030001	630	6	18204	49	CACHD1,ATP1A2,SLC1A3,RYR3,SLC4A4,GPM6A
6.709e-03	-5.00	apical junction complex	cellular component	GO:0043296	150	3	19108	49	PARD3B,SORBS1,SHROOM3
6.841e-03	-4.98	face	COSMIC cancer mutations	face	2139	13	16828	49	AQP4,PREX2,ZNRF3,GPC5,LSAMP,FMN2,RORA,MACF1,GPM6A,FGFR3,MSI2,ABLIM1,GABRB1
6.875e-03	-4.98	Ig_3	pfam domains	PF13927	141	3	17795	49	FGFR3,NTM,LSAMP
6.896e-03	-4.98	Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME pathways	R-HSA-432040	43	2	10285	30	AQP4,ADCY2
6.941e-03	-4.97	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	7	16828	49	BMPR1B,SOX5,NTRK2,FGFR3,TNIK,ADCY2,CTNND2
6.941e-03	-4.97	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	7	16828	49	TNIK,FGFR3,BMPR1B,SOX5,NTRK2,CTNND2,ADCY2
7.087e-03	-4.95	symporter activity	molecular function	GO:0015293	148	3	18094	48	SLC1A2,SLC1A3,SLC4A4
7.111e-03	-4.95	adult behavior	biological process	GO:0030534	146	3	18204	49	PREX2,SLC1A2,ATP1A2
7.175e-03	-4.94	PDZ	interpro domains	IPR001478	146	3	18521	50	PREX2,SHROOM3,PARD3B
7.191e-03	-4.93	ELFV_dehydrog	smart domains	SM00839	2	1	9717	35	GLUD1
7.209e-03	-4.93	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	44	SPARCL1
7.209e-03	-4.93	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	44	SPARCL1
7.209e-03	-4.93	GLFV_DEHYDROGENASE	prosite domains	PS00074	2	1	12186	44	GLUD1
7.363e-03	-4.91	Signaling by Hedgehog	REACTOME pathways	R-HSA-5358351	138	3	10285	30	GPC5,ADCY2,GLI3
7.426e-03	-4.90	ATPASE_E1_E2	prosite domains	PS00154	36	2	12186	44	ATP1A2,ATP13A4
7.490e-03	-4.89	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	30	16828	49	RANBP3L,NTM,ATP1A2,CACHD1,MACF1,SOX5,NPAS3,SLC4A4,RFX4,GLI3,RORA,SLC1A2,ZNRF3,PREX2,GNA14,PARD3B,FGFR3,NTRK2,FMN2,RYR3,CTNND2,ATP13A4,STON2,FBXL7,SFXN5,LSAMP,ADCY2,PITPNC1,AQP4,NHSL1
7.490e-03	-4.89	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	30	16828	49	FMN2,NTRK2,PARD3B,FGFR3,GNA14,ATP13A4,STON2,CTNND2,RYR3,FBXL7,SFXN5,PITPNC1,AQP4,NHSL1,ADCY2,LSAMP,MACF1,SOX5,ATP1A2,CACHD1,RANBP3L,NTM,SLC4A4,NPAS3,GLI3,RORA,RFX4,PREX2,ZNRF3,SLC1A2
7.493e-03	-4.89	cell surface	cellular component	GO:0009986	896	7	19108	49	SLC1A3,FGFR3,AQP4,GPC5,SLC1A2,ATP1A2,SLC4A4
7.587e-03	-4.88	PDZ_sf	interpro domains	IPR036034	149	3	18521	50	PARD3B,SHROOM3,PREX2
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	NHSL1,MACF1
7.640e-03	-4.87	synaptic signaling	biological process	GO:0099536	459	5	18204	49	NTRK2,DTNA,SLC1A3,GABRB1,SLC1A2
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Shh (sonic hedgehog)	protein interactions	20423	3	1	19454	50	GLI3
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.720e-03	-4.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	10	16828	49	TNIK,GABRB1,FMN2,CACHD1,CTNND2,SORBS1,RYR3,LSAMP,SLC4A4,GPC5
7.762e-03	-4.86	anchoring junction	cellular component	GO:0070161	902	7	19108	49	SHROOM3,ATP1A2,PARD3B,CTNNA2,CTNND2,FGFR3,SORBS1
7.800e-03	-4.85	abdomen	COSMIC cancer mutations	abdomen	603	6	16828	49	FMN2,STON2,PREX2,FGFR3,CTNND2,RANBP3L
7.909e-03	-4.84	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	50	SORBS1,NTRK2
7.917e-03	-4.84	regulation of membrane potential	biological process	GO:0042391	463	5	18204	49	NTRK2,SLC4A4,ATP1A2,GNA14,GABRB1
7.938e-03	-4.84	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular function	GO:0008454	3	1	18094	48	MGAT4C
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
8.020e-03	-4.83	FORMIN	prints domains	PR00828	2	1	5227	21	FMN2
8.020e-03	-4.83	GLFDHDRGNASE	prints domains	PR00082	2	1	5227	21	GLUD1
8.054e-03	-4.82	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	49	FMN2
8.054e-03	-4.82	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	49	CTNNA2
8.054e-03	-4.82	smoothened signaling pathway involved in ventral spinal cord interneuron specification	biological process	GO:0021775	3	1	18204	49	GLI3
8.054e-03	-4.82	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	49	SLC1A2
8.054e-03	-4.82	cysteine transport	biological process	GO:0042883	3	1	18204	49	SLC1A2
8.054e-03	-4.82	smoothened signaling pathway involved in ventral spinal cord patterning	biological process	GO:0021910	3	1	18204	49	GLI3
8.054e-03	-4.82	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	49	FMN2
8.054e-03	-4.82	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	49	ATP1A2
8.054e-03	-4.82	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	49	FMN2
8.054e-03	-4.82	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	49	NTRK2
8.054e-03	-4.82	nose morphogenesis	biological process	GO:0043585	3	1	18204	49	GLI3
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	ASD1_dom	interpro domains	IPR014800	3	1	18521	50	SHROOM3
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	SHD_dom	interpro domains	IPR012320	3	1	18521	50	STON2
8.078e-03	-4.82	HIF_alpha-like	interpro domains	IPR021537	3	1	18521	50	HIF3A
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.078e-03	-4.82	GABAAb_rcpt	interpro domains	IPR002289	3	1	18521	50	GABRB1
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	Stonin	interpro domains	IPR017110	3	1	18521	50	STON2
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.088e-03	-4.82	amino acid binding	molecular function	GO:0016597	51	2	18094	48	SLC1A3,GLUD1
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	MACF1,SORBS1,DTNA,SHROOM3
8.124e-03	-4.81	neuronal cell body	cellular component	GO:0043025	489	5	19108	49	BMPR1B,SLC1A3,CTNND2,GPM6A,ATP1A2
8.238e-03	-4.80	SR_plectin_7	pfam domains	PF21097	3	1	17795	49	MACF1
8.238e-03	-4.80	HIF-1	pfam domains	PF11413	3	1	17795	49	HIF3A
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR3
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR3
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR3
8.238e-03	-4.80	Myelin_PLP	pfam domains	PF01275	3	1	17795	49	GPM6A
8.238e-03	-4.80	ASD1	pfam domains	PF08688	3	1	17795	49	SHROOM3
8.238e-03	-4.80	Sorb	pfam domains	PF02208	3	1	17795	49	SORBS1
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK2
8.267e-03	-4.80	carboxylic acid transport	biological process	GO:0046942	297	4	18204	49	NTRK2,SLC1A2,SFXN5,SLC1A3
8.301e-03	-4.79	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	16	16828	49	NTM,FGFR3,SHROOM3,CACHD1,NTRK2,ATP1A2,BMPR1B,FMN2,MACF1,NPAS3,SLC4A4,MSI2,GLI3,ADCY2,SPARCL1,HIF3A
8.301e-03	-4.79	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	16	16828	49	GLI3,MSI2,HIF3A,ADCY2,SPARCL1,ATP1A2,NTRK2,CACHD1,MACF1,BMPR1B,FMN2,SHROOM3,FGFR3,NTM,NPAS3,SLC4A4
8.363e-03	-4.78	organic acid transport	biological process	GO:0015849	298	4	18204	49	SFXN5,SLC1A2,SLC1A3,NTRK2
8.446e-03	-4.77	CATATPASE	prints domains	PR00119	35	2	5227	21	ATP13A4,ATP1A2
8.525e-03	-4.76	retina development in camera-type eye	biological process	GO:0060041	156	3	18204	49	GPM6A,BMPR1B,NTRK2
8.675e-03	-4.75	regulation of osteoblast differentiation	biological process	GO:0045667	157	3	18204	49	GLI3,RANBP3L,BMPR1B
8.711e-03	-4.74	skin-forearm-lentigo	COSMIC cancer mutations	skin-forearm-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-lentigo	COSMIC cancer mutations	skin-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-hand-lentigo	COSMIC cancer mutations	skin-hand-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-face-lentigo	COSMIC cancer mutations	skin-face-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-leg-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	urinary_tract-bladder-papilloma	COSMIC cancer mutations	urinary_tract-bladder-papilloma	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-trunk-other-seborrhoeic_keratosis	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-trunk-lentigo	COSMIC cancer mutations	skin-trunk-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	skin-leg-lentigo	COSMIC cancer mutations	skin-leg-lentigo	3	1	16828	49	FGFR3
8.711e-03	-4.74	lentigo	COSMIC cancer mutations	lentigo	3	1	16828	49	FGFR3
8.712e-03	-4.74	ATPase-coupled monoatomic cation transmembrane transporter activity	molecular function	GO:0019829	53	2	18094	48	ATP13A4,ATP1A2
8.726e-03	-4.74	GLI proteins bind promoters of Hh responsive genes to promote transcription	REACTOME pathways	R-HSA-5635851	3	1	10285	30	GLI3
8.748e-03	-4.74	ZYX (zyxin)	protein interactions	7791	316	4	19454	50	MACF1,SORBS1,ABLIM1,SHROOM3
8.869e-03	-4.73	mannosyl-glycoprotein N-acetylglucosaminyltransferases	BIOCYC pathways	META_PWY-7426	8	1	902	1	MGAT4C
8.962e-03	-4.71	neutral amino acid transport	biological process	GO:0015804	53	2	18204	49	SLC1A3,SLC1A2
9.053e-03	-4.70	CTNNB1 (catenin beta 1)	protein interactions	1499	926	7	19454	50	CTNND2,DTNA,PARD3B,NHSL1,CTNNA2,SORBS1,SHROOM3
9.087e-03	-4.70	metal ion binding	molecular function	GO:0046872	4239	19	18094	48	ABLIM1,GNA14,GLIS3,MGAT4C,RYR3,RORA,SPARCL1,SLC1A2,GLI3,SLC1A3,BMPR1B,MACF1,ADCY2,ATP1A2,DTNA,PAMR1,CPE,ATP13A4,ZNRF3
9.095e-03	-4.70	-	gene3d domains	1.10.490.160	3	1	14470	44	RYR3
9.095e-03	-4.70	-	gene3d domains	6.10.250.2510	3	1	14470	44	CTNNA2
9.147e-03	-4.69	presynaptic membrane	cellular component	GO:0042734	168	3	19108	49	GPM6A,SLC1A2,GABRB1
9.156e-03	-4.69	ear	COSMIC cancer mutations	ear	624	6	16828	49	GABRB1,FGFR3,SPARCL1,STON2,MGAT4C,NPAS3
9.191e-03	-4.69	EF-hand	gene3d domains	1.10.238.10	272	4	14470	44	SPARCL1,MACF1,DTNA,RYR3
9.212e-03	-4.69	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	45	16828	49	ATP13A4,RYR3,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,ADCY2,AQP4,NPAS3,ATP1A2,BMPR1B,RANBP3L,PAMR1,SLC1A3,GPM6A,STON2,CTNND2,SORBS1,CPE,NTRK2,FGFR3,HIF3A,NHSL1,MGAT4C,LSAMP,SFXN5,GLUD1,FBXL7,TNIK,GPC5,SLC4A4,CACHD1,NKAIN3,MACF1,SOX5,NTM,SPARCL1,ZNRF3,PREX2,SLC1A2,RORA,GLI3,GABRB1,RFX4
9.290e-03	-4.68	inorganic anion transport	biological process	GO:0015698	161	3	18204	49	GABRB1,SLC1A3,SLC4A4
9.475e-03	-4.66	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	40	16828	49	SLC1A2,SLC1A3,PREX2,PAMR1,ZNRF3,GABRB1,GLI3,DTNA,RORA,NPAS3,SLC4A4,GPC5,RANBP3L,NTM,SOX5,MACF1,BMPR1B,ATP1A2,CACHD1,LSAMP,MGAT4C,NHSL1,ADCY2,MSI2,TNIK,FBXL7,GLUD1,SFXN5,SORBS1,CTNND2,RYR3,ATP13A4,PARD3B,SHROOM3,FGFR3,GNA14,FMN2,GLIS3,NTRK2,CPE
9.564e-03	-4.65	side of membrane	cellular component	GO:0098552	715	6	19108	49	GPC5,AQP4,GNA14,LSAMP,NTM,DTNA
9.597e-03	-4.65	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	30	SLC1A2,SLC1A3
9.625e-03	-4.64	response to cocaine	biological process	GO:0042220	55	2	18204	49	SLC1A2,SLC1A3
9.634e-03	-4.64	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	49	16828	49	NTRK2,CPE,ABLIM1,FGFR3,STON2,SORBS1,CTNND2,FBXL7,GLUD1,SFXN5,MSI2,TNIK,HIF3A,MGAT4C,NHSL1,LSAMP,CACHD1,SOX5,MACF1,NKAIN3,NTM,GPC5,SLC4A4,GLI3,DTNA,RORA,GABRB1,RFX4,ZNRF3,SPARCL1,PREX2,SLC1A2,GLIS3,FMN2,GNA14,PARD3B,SHROOM3,ATP13A4,RYR3,ADCY2,PITPNC1,AQP4,ATP1A2,BMPR1B,RANBP3L,NPAS3,GPM6A,SLC1A3,PAMR1
9.634e-03	-4.64	LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)	protein interactions	55004	714	6	19454	50	CACHD1,TNIK,DTNA,STON2,SLC1A3,FMN2
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	ATP1A2,GPM6A,NTRK2
9.929e-03	-4.61	import across plasma membrane	biological process	GO:0098739	165	3	18204	49	SLC1A2,SLC1A3,ATP1A2
9.950e-03	-4.61	CAV1 (caveolin 1)	protein interactions	857	719	6	19454	50	DTNA,MACF1,TNIK,CACHD1,FMN2,SLC1A3
9.963e-03	-4.61	Aquaporin-mediated transport	REACTOME pathways	R-HSA-445717	52	2	10285	30	AQP4,ADCY2
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	NTRK2,GPM6A,ATP1A2
1.008e-02	-4.60	cellular homeostasis	biological process	GO:0019725	689	6	18204	49	RYR3,SLC1A3,AQP4,ATP1A2,ATP13A4,SLC4A4
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	GNA14,CTNNA2,DTNA
1.022e-02	-4.58	GLI-SUFU complex	cellular component	GO:1990788	4	1	19108	49	GLI3
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Sufu (SUFU negative regulator of hedgehog signaling)	protein interactions	24069	4	1	19454	50	GLI3
1.027e-02	-4.58	IGc2	smart domains	SM00408	239	4	9717	35	FGFR3,NTRK2,LSAMP,NTM
1.031e-02	-4.57	visual behavior	biological process	GO:0007632	57	2	18204	49	ATP1A2,SLC1A2
1.031e-02	-4.57	neuroblast proliferation	biological process	GO:0007405	57	2	18204	49	SOX5,GLI3
1.034e-02	-4.57	channel activity	molecular function	GO:0015267	502	5	18094	48	AQP4,RYR3,CACHD1,GABRB1,GPM6A
1.041e-02	-4.56	-	gene3d domains	2.30.42.10	149	3	14470	44	PREX2,SHROOM3,PARD3B
1.042e-02	-4.56	SNTB1 (syntrophin beta 1)	protein interactions	6641	60	2	19454	50	FGFR3,DTNA
1.042e-02	-4.56	passive transmembrane transporter activity	molecular function	GO:0022803	503	5	18094	48	AQP4,GPM6A,GABRB1,RYR3,CACHD1
1.057e-02	-4.55	mediator complex binding	molecular function	GO:0036033	4	1	18094	48	GLI3
1.057e-02	-4.55	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	48	NTRK2
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.057e-02	-4.55	tricarboxylic acid transmembrane transporter activity	molecular function	GO:0015142	4	1	18094	48	SFXN5
1.057e-02	-4.55	citrate transmembrane transporter activity	molecular function	GO:0015137	4	1	18094	48	SFXN5
1.065e-02	-4.54	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	44	16828	49	SLC1A2,SPARCL1,PREX2,GABRB1,RFX4,GLI3,RORA,GPC5,SLC4A4,NTM,CACHD1,SOX5,MACF1,NKAIN3,LSAMP,MGAT4C,NHSL1,MSI2,TNIK,FBXL7,GLUD1,SFXN5,SORBS1,CTNND2,STON2,ABLIM1,FGFR3,NTRK2,CPE,SLC1A3,PAMR1,GPM6A,RANBP3L,ATP1A2,BMPR1B,ADCY2,AQP4,RYR3,ATP13A4,GNA14,SHROOM3,PARD3B,GLIS3,FMN2
1.070e-02	-4.54	chemical homeostasis	biological process	GO:0048878	914	7	18204	49	AQP4,RORA,ATP1A2,RYR3,SLC1A3,SLC4A4,ATP13A4
1.072e-02	-4.54	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	biological process	GO:0060831	4	1	18204	49	GLI3
1.072e-02	-4.54	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	49	ATP1A2
1.072e-02	-4.54	glutamate biosynthetic process	biological process	GO:0006537	4	1	18204	49	GLUD1
1.072e-02	-4.54	protein localization to secretory granule	biological process	GO:0033366	4	1	18204	49	CPE
1.072e-02	-4.54	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	49	ATP1A2
1.072e-02	-4.54	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	49	NTRK2
1.072e-02	-4.54	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	49	NTRK2
1.072e-02	-4.54	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	49	BMPR1B
1.072e-02	-4.54	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	49	SOX5
1.072e-02	-4.54	frontal suture morphogenesis	biological process	GO:0060364	4	1	18204	49	GLI3
1.072e-02	-4.54	response to glycoside	biological process	GO:1903416	4	1	18204	49	ATP1A2
1.076e-02	-4.53	P5A-ATPase_N	interpro domains	IPR047819	4	1	18521	50	ATP13A4
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	Shroom_fam	interpro domains	IPR027685	4	1	18521	50	SHROOM3
1.076e-02	-4.53	P5B-type_ATPase	interpro domains	IPR047821	4	1	18521	50	ATP13A4
1.076e-02	-4.53	Gprotein_alpha_Q	interpro domains	IPR000654	4	1	18521	50	GNA14
1.076e-02	-4.53	Glyco_transf_54	interpro domains	IPR006759	4	1	18521	50	MGAT4C
1.076e-02	-4.53	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	1	18521	50	MACF1
1.076e-02	-4.53	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	1	18521	50	MACF1
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	FGF_rcpt_fam	interpro domains	IPR016248	4	1	18521	50	FGFR3
1.076e-02	-4.53	ASD2_dom	interpro domains	IPR014799	4	1	18521	50	SHROOM3
1.076e-02	-4.53	response to organonitrogen compound	biological process	GO:0010243	915	7	18204	49	GNA14,GABRB1,SLC1A3,RYR3,SORBS1,SLC1A2,TNIK
1.077e-02	-4.53	Sorb	smart domains	SM00459	3	1	9717	35	SORBS1
1.077e-02	-4.53	PLP	smart domains	SM00002	3	1	9717	35	GPM6A
1.079e-02	-4.53	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	44	GPM6A
1.079e-02	-4.53	SHD	prosite domains	PS51070	3	1	12186	44	STON2
1.079e-02	-4.53	VINCULIN_1	prosite domains	PS00663	3	1	12186	44	CTNNA2
1.079e-02	-4.53	SOHO	prosite domains	PS50831	3	1	12186	44	SORBS1
1.079e-02	-4.53	ASD1	prosite domains	PS51306	3	1	12186	44	SHROOM3
1.079e-02	-4.53	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	44	GPM6A
1.080e-02	-4.53	ACTB (actin beta)	protein interactions	60	958	7	19454	50	SORBS1,SFXN5,NHSL1,FMN2,MACF1,ABLIM1,DTNA
1.082e-02	-4.53	skeletal system development	biological process	GO:0001501	500	5	18204	49	RANBP3L,FGFR3,GLI3,SOX5,BMPR1B
1.092e-02	-4.52	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	45	16828	49	NTM,NKAIN3,SOX5,MACF1,CACHD1,SLC4A4,GPC5,RFX4,GABRB1,RORA,GLI3,DTNA,SLC1A2,PREX2,ZNRF3,FGFR3,ABLIM1,NTRK2,CTNND2,SORBS1,STON2,TNIK,MSI2,SFXN5,FBXL7,LSAMP,NHSL1,MGAT4C,HIF3A,RANBP3L,BMPR1B,ATP1A2,NPAS3,GPM6A,PAMR1,SLC1A3,SHROOM3,PARD3B,GNA14,FMN2,GLIS3,RYR3,ATP13A4,PITPNC1,ADCY2
1.097e-02	-4.51	AbLIM_anchor	pfam domains	PF16182	4	1	17795	49	ABLIM1
1.097e-02	-4.51	Spectrin_4	pfam domains	PF21020	4	1	17795	49	MACF1
1.097e-02	-4.51	NHS	pfam domains	PF15273	4	1	17795	49	NHSL1
1.097e-02	-4.51	ASD2	pfam domains	PF08687	4	1	17795	49	SHROOM3
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	Spectrin_3	pfam domains	PF21019	4	1	17795	49	MACF1
1.097e-02	-4.51	Glyco_transf_54	pfam domains	PF04666	4	1	17795	49	MGAT4C
1.097e-02	-4.51	Spectrin_2	pfam domains	PF18373	4	1	17795	49	MACF1
1.097e-02	-4.51	P5-ATPase	pfam domains	PF12409	4	1	17795	49	ATP13A4
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	ADCY2,AQP4,PITPNC1,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,ATP13A4,RYR3,GPM6A,PAMR1,SLC1A3,ATP1A2,BMPR1B,RANBP3L,NPAS3,SFXN5,FBXL7,GLUD1,TNIK,MSI2,HIF3A,NHSL1,MGAT4C,LSAMP,CPE,NTRK2,ABLIM1,FGFR3,STON2,CTNND2,SORBS1,RORA,DTNA,GLI3,GABRB1,RFX4,SPARCL1,ZNRF3,PREX2,SLC1A2,CACHD1,NKAIN3,MACF1,SOX5,NTM,GPC5,SLC4A4
1.101e-02	-4.51	endochondral bone morphogenesis	biological process	GO:0060350	59	2	18204	49	BMPR1B,FGFR3
1.103e-02	-4.51	skin-upper_leg-malignant_melanoma	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma	850	7	16828	49	STON2,PAMR1,PREX2,HIF3A,SHROOM3,FMN2,GLIS3
1.104e-02	-4.51	EZR (ezrin)	protein interactions	7430	526	5	19454	50	MACF1,TNIK,SORBS1,ABLIM1,DTNA
1.118e-02	-4.49	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	49	GPC5,PAMR1,MACF1,RYR3
1.126e-02	-4.49	monoatomic cation homeostasis	biological process	GO:0055080	505	5	18204	49	SLC4A4,ATP13A4,ATP1A2,RYR3,SLC1A3
1.137e-02	-4.48	regulation of glucose import	biological process	GO:0046324	60	2	18204	49	SLC1A2,SORBS1
1.137e-02	-4.48	export across plasma membrane	biological process	GO:0140115	60	2	18204	49	ATP1A2,SLC4A4
1.137e-02	-4.48	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	49	ATP1A2,NTRK2
1.137e-02	-4.48	protein homotetramerization	biological process	GO:0051289	60	2	18204	49	RYR3,AQP4
1.138e-02	-4.48	head_neck	COSMIC cancer mutations	head_neck	15361	49	16828	49	GPM6A,SLC1A3,PAMR1,RANBP3L,BMPR1B,ATP1A2,NPAS3,PITPNC1,AQP4,ADCY2,PARD3B,SHROOM3,GNA14,FMN2,GLIS3,RYR3,ATP13A4,RFX4,GABRB1,GLI3,DTNA,RORA,SLC1A2,PREX2,SPARCL1,ZNRF3,NTM,MACF1,SOX5,NKAIN3,CACHD1,SLC4A4,GPC5,MSI2,TNIK,FBXL7,GLUD1,SFXN5,LSAMP,MGAT4C,NHSL1,HIF3A,FGFR3,ABLIM1,NTRK2,CPE,SORBS1,CTNND2,STON2
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.145e-02	-4.47	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	8	19454	50	FMN2,NHSL1,PARD3B,SHROOM3,PITPNC1,SORBS1,ABLIM1,MACF1
1.148e-02	-4.47	adrenal_cortical_adenoma	COSMIC cancer mutations	adrenal_cortical_adenoma	161	3	16828	49	FMN2,CACHD1,ADCY2
1.149e-02	-4.47	GABA receptor activation	REACTOME pathways	R-HSA-977443	56	2	10285	30	GABRB1,ADCY2
1.149e-02	-4.47	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	2	10285	30	RYR3,ATP1A2
1.160e-02	-4.46	skin-benign_melanocytic_nevus-junctional	COSMIC cancer mutations	skin-benign_melanocytic_nevus-junctional	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.160e-02	-4.46	inverted	COSMIC cancer mutations	inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	urinary_tract-bladder-other-normal	COSMIC cancer mutations	urinary_tract-bladder-other-normal	4	1	16828	49	FGFR3
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.160e-02	-4.46	urinary_tract-bladder-papilloma-inverted	COSMIC cancer mutations	urinary_tract-bladder-papilloma-inverted	4	1	16828	49	FGFR3
1.160e-02	-4.46	Ectoderm Differentiation	WikiPathways	WP2858	143	3	5310	18	GLI3,CTNND2,CTNNA2
1.166e-02	-4.45	ion binding	molecular function	GO:0043167	6007	24	18094	48	FGFR3,ATP13A4,PAMR1,GLUD1,BMPR1B,SLC1A2,SPARCL1,MGAT4C,GNA14,ABLIM1,NTRK2,PITPNC1,ZNRF3,CPE,TNIK,DTNA,ATP1A2,MACF1,ADCY2,SLC1A3,GLI3,RORA,RYR3,GLIS3
1.169e-02	-4.45	postsynaptic specialization	cellular component	GO:0099572	345	4	19108	49	GABRB1,NTRK2,CTNND2,TNIK
1.178e-02	-4.44	transmembrane receptor protein tyrosine kinase activity	molecular function	GO:0004714	62	2	18094	48	FGFR3,NTRK2
1.201e-02	-4.42	RYANODINER	prints domains	PR00795	3	1	5227	21	RYR3
1.201e-02	-4.42	NTKRECEPTOR	prints domains	PR01939	3	1	5227	21	NTRK2
1.201e-02	-4.42	GABAARBETA	prints domains	PR01160	3	1	5227	21	GABRB1
1.201e-02	-4.42	RORNUCRECPTR	prints domains	PR01293	3	1	5227	21	RORA
1.201e-02	-4.42	MYELINPLP	prints domains	PR00214	3	1	5227	21	GPM6A
1.205e-02	-4.42	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	30	16828	49	SPARCL1,PREX2,SLC1A3,PAMR1,DTNA,GLI3,RORA,NPAS3,SLC4A4,ATP1A2,CACHD1,SOX5,MACF1,NKAIN3,HIF3A,ADCY2,TNIK,RYR3,SORBS1,CTNND2,ATP13A4,STON2,GNA14,ABLIM1,PARD3B,SHROOM3,FGFR3,NTRK2,GLIS3,FMN2
1.209e-02	-4.42	kidney	COSMIC cancer mutations	kidney	15380	49	16828	49	CTNND2,SORBS1,STON2,FGFR3,ABLIM1,CPE,NTRK2,LSAMP,NHSL1,MGAT4C,HIF3A,TNIK,MSI2,SFXN5,GLUD1,FBXL7,SLC4A4,GPC5,NTM,NKAIN3,SOX5,MACF1,CACHD1,SLC1A2,PREX2,SPARCL1,ZNRF3,RFX4,GABRB1,RORA,GLI3,DTNA,RYR3,ATP13A4,SHROOM3,PARD3B,GNA14,FMN2,GLIS3,AQP4,PITPNC1,ADCY2,NPAS3,RANBP3L,BMPR1B,ATP1A2,PAMR1,SLC1A3,GPM6A
1.211e-02	-4.41	-	gene3d domains	6.10.250.3120	4	1	14470	44	SHROOM3
1.211e-02	-4.41	-	gene3d domains	1.20.58.1060	4	1	14470	44	MACF1
1.216e-02	-4.41	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	49	PAMR1,MACF1,GPM6A,GPC5,RYR3
1.218e-02	-4.41	monoatomic ion homeostasis	biological process	GO:0050801	515	5	18204	49	SLC4A4,ATP13A4,ATP1A2,RYR3,SLC1A3
1.223e-02	-4.40	astrocytoma_Grade_III	COSMIC cancer mutations	astrocytoma_Grade_III	1544	10	16828	49	GNA14,GABRB1,SHROOM3,FGFR3,CACHD1,RYR3,GPC5,ADCY2,STON2,PAMR1
1.223e-02	-4.40	D-Glutamine and D-glutamate metabolism	KEGG pathways	hsa00471	4	1	7161	22	GLUD1
1.223e-02	-4.40	D-Glutamine and D-glutamate metabolism	KEGG pathways	ko00471	4	1	7161	22	GLUD1
1.229e-02	-4.40	Ion transport by P-type ATPases	REACTOME pathways	R-HSA-936837	58	2	10285	30	ATP13A4,ATP1A2
1.245e-02	-4.39	camera-type eye development	biological process	GO:0043010	335	4	18204	49	BMPR1B,NTRK2,GPM6A,GLI3
1.249e-02	-4.38	back	COSMIC cancer mutations	back	310	4	16828	49	PREX2,ATP1A2,TNIK,FGFR3
1.250e-02	-4.38	cell adhesion	biological process	GO:0007155	942	7	18204	49	CTNND2,LSAMP,SORBS1,NTM,CTNNA2,SPARCL1,PARD3B
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	TRH (thyrotropin releasing hormone)	protein interactions	7200	5	1	19454	50	CPE
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.287e-02	-4.35	cranial nerve development	biological process	GO:0021545	64	2	18204	49	GLI3,SLC1A3
1.287e-02	-4.35	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	49	FMN2,SORBS1
1.302e-02	-4.34	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	18	SLC1A3,ATP1A2
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	ATP13A4,STON2,RYR3,SORBS1,CTNND2,GLIS3,NTRK2,CPE,FMN2,ABLIM1,GNA14,PARD3B,SHROOM3,FGFR3,HIF3A,ADCY2,PITPNC1,MGAT4C,NHSL1,AQP4,LSAMP,GLUD1,FBXL7,SFXN5,MSI2,TNIK,GPC5,NPAS3,SLC4A4,ATP1A2,CACHD1,MACF1,SOX5,BMPR1B,NKAIN3,RANBP3L,NTM,SPARCL1,ZNRF3,SLC1A3,PREX2,PAMR1,SLC1A2,GPM6A,GLI3,RORA,GABRB1,RFX4
1.312e-02	-4.33	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	3	18204	49	SORBS1,RORA,SLC4A4
1.317e-02	-4.33	carboxylic acid transmembrane transporter activity	molecular function	GO:0046943	186	3	18094	48	SFXN5,SLC1A3,SLC1A2
1.320e-02	-4.33	fibroblast growth factor receptor activity	molecular function	GO:0005007	5	1	18094	48	FGFR3
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.320e-02	-4.33	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	48	NTRK2
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A2,SLC1A3
1.328e-02	-4.32	signal transduction	biological process	GO:0007165	4637	20	18204	49	FGFR3,TNIK,ADCY2,SPARCL1,GLI3,GNA14,FMN2,RORA,CPE,ATP1A2,ZNRF3,SORBS1,RYR3,PREX2,PITPNC1,NTRK2,BMPR1B,CTNND2,MACF1,DTNA
1.330e-02	-4.32	cellular response to stimulus	biological process	GO:0051716	6307	25	18204	49	GNA14,AQP4,CPE,ADCY2,TNIK,MACF1,DTNA,SHROOM3,SLC1A2,RYR3,ATP1A2,NTRK2,PITPNC1,GLI3,GABRB1,RORA,FMN2,FGFR3,SLC1A3,SPARCL1,CTNND2,SORBS1,ZNRF3,PREX2,BMPR1B
1.332e-02	-4.32	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	5	16828	49	TNIK,FGFR3,NTRK2,BMPR1B,MACF1
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.336e-02	-4.32	organic acid transmembrane transporter activity	molecular function	GO:0005342	187	3	18094	48	SLC1A3,SFXN5,SLC1A2
1.339e-02	-4.31	citrate transport	biological process	GO:0015746	5	1	18204	49	SFXN5
1.339e-02	-4.31	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	49	NTRK2
1.339e-02	-4.31	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	49	FMN2
1.339e-02	-4.31	tricarboxylic acid transport	biological process	GO:0006842	5	1	18204	49	SFXN5
1.339e-02	-4.31	amygdala development	biological process	GO:0021764	5	1	18204	49	ATP1A2
1.339e-02	-4.31	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	49	BMPR1B
1.342e-02	-4.31	salivary_gland-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma-adenoid_cystic_carcinoma	488	5	16828	49	MGAT4C,RORA,RYR3,GABRB1,CTNND2
1.343e-02	-4.31	Mtc	interpro domains	IPR004686	5	1	18521	50	SFXN5
1.343e-02	-4.31	P-type_TPase_V	interpro domains	IPR006544	5	1	18521	50	ATP13A4
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.356e-02	-4.30	arm	COSMIC cancer mutations	arm	1331	9	16828	49	FGFR3,NTM,PARD3B,SHROOM3,MACF1,ATP1A2,SORBS1,NPAS3,SLC4A4
1.364e-02	-4.29	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	49	SLC1A3,SLC1A2
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	NTM,CACHD1,SOX5,MACF1,NKAIN3,GPC5,SLC4A4,GABRB1,RFX4,GLI3,DTNA,RORA,SLC1A2,SPARCL1,ZNRF3,PREX2,ABLIM1,FGFR3,NTRK2,CPE,SORBS1,CTNND2,STON2,MSI2,TNIK,GLUD1,FBXL7,SFXN5,LSAMP,HIF3A,MGAT4C,NHSL1,RANBP3L,ATP1A2,BMPR1B,NPAS3,GPM6A,SLC1A3,PAMR1,GNA14,SHROOM3,PARD3B,GLIS3,FMN2,RYR3,ATP13A4,ADCY2,AQP4
1.369e-02	-4.29	Vinculin	pfam domains	PF01044	5	1	17795	49	CTNNA2
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.369e-02	-4.29	SFXNs	pfam domains	PF03820	5	1	17795	49	SFXN5
1.369e-02	-4.29	FOLN	pfam domains	PF09289	5	1	17795	49	SPARCL1
1.387e-02	-4.28	non_seminoma	COSMIC cancer mutations	non_seminoma	492	5	16828	49	FGFR3,TNIK,NTRK2,MACF1,BMPR1B
1.392e-02	-4.27	calcium channel complex	cellular component	GO:0034704	70	2	19108	49	CACHD1,RYR3
1.399e-02	-4.27	PCDH20 (protocadherin 20)	protein interactions	64881	70	2	19454	50	CTNNA2,MGAT4C
1.404e-02	-4.27	virilizing_syndrome_producing	COSMIC cancer mutations	virilizing_syndrome_producing	321	4	16828	49	CACHD1,ATP1A2,FMN2,CTNND2
1.407e-02	-4.26	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	5	19454	50	DTNA,MACF1,CACHD1,FMN2,SLC1A3
1.418e-02	-4.26	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	49	NPAS3,RANBP3L,BMPR1B,ATP1A2,SLC1A3,PAMR1,GPM6A,RYR3,ATP13A4,SHROOM3,PARD3B,GNA14,FMN2,GLIS3,PITPNC1,AQP4,ADCY2,SLC4A4,GPC5,NTM,SOX5,MACF1,NKAIN3,CACHD1,SLC1A2,PREX2,ZNRF3,SPARCL1,RFX4,GABRB1,DTNA,GLI3,RORA,SORBS1,CTNND2,STON2,FGFR3,ABLIM1,NTRK2,CPE,LSAMP,MGAT4C,NHSL1,HIF3A,TNIK,GLUD1,FBXL7,SFXN5
1.418e-02	-4.26	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	49	FGFR3,ABLIM1,NTRK2,CPE,SORBS1,CTNND2,STON2,TNIK,GLUD1,FBXL7,SFXN5,LSAMP,MGAT4C,NHSL1,HIF3A,NTM,SOX5,MACF1,NKAIN3,CACHD1,SLC4A4,GPC5,RFX4,GABRB1,GLI3,DTNA,RORA,SLC1A2,PREX2,SPARCL1,ZNRF3,PARD3B,SHROOM3,GNA14,FMN2,GLIS3,RYR3,ATP13A4,PITPNC1,AQP4,ADCY2,RANBP3L,BMPR1B,ATP1A2,NPAS3,GPM6A,SLC1A3,PAMR1
1.429e-02	-4.25	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	12	16828	49	BMPR1B,DTNA,SOX5,GLI3,CACHD1,NTRK2,ATP1A2,FGFR3,TNIK,SLC4A4,PREX2,ADCY2
1.433e-02	-4.25	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	4	16828	49	ADCY2,PARD3B,SORBS1,NTM
1.437e-02	-4.24	ASD2	prosite domains	PS51307	4	1	12186	44	SHROOM3
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	TNIK,GPM6A
1.444e-02	-4.24	actin filament bundle organization	biological process	GO:0061572	68	2	18204	49	SORBS1,FMN2
1.448e-02	-4.24	lichenoid_keratosis	COSMIC cancer mutations	lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_arm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_arm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-nevus_sebaceous	COSMIC cancer mutations	skin-shoulder-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-shoulder-other-lichenoid_keratosis	COSMIC cancer mutations	skin-shoulder-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-flank-other-lichenoid_keratosis	COSMIC cancer mutations	skin-flank-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-lichenoid_keratosis	COSMIC cancer mutations	skin-face-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.448e-02	-4.24	skin-neck-other-nevus_sebaceous	COSMIC cancer mutations	skin-neck-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	syringocystadenoma_papilliferum	COSMIC cancer mutations	syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-arm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-arm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hip-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-hip-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-neck-other-lichenoid_keratosis	COSMIC cancer mutations	skin-neck-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-other-lichenoid_keratosis	COSMIC cancer mutations	skin-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-forearm-other-seborrhoeic_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-chest-other-lichenoid_keratosis	COSMIC cancer mutations	skin-chest-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-nevus_sebaceous	COSMIC cancer mutations	skin-lower_back-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-forearm-other-lichenoid_keratosis	COSMIC cancer mutations	skin-forearm-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-hand-other-lichenoid_keratosis	COSMIC cancer mutations	skin-hand-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	monoclonal_gammopathy_of_undetermined_significance	COSMIC cancer mutations	monoclonal_gammopathy_of_undetermined_significance	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-face-other-nevus_sebaceous	COSMIC cancer mutations	skin-face-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-lichenoid_keratosis	COSMIC cancer mutations	skin-breast-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-lower_leg-other-lichenoid_keratosis	COSMIC cancer mutations	skin-lower_leg-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-scalp-other-nevus_sebaceous	COSMIC cancer mutations	skin-scalp-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-upper_back-other-lichenoid_keratosis	COSMIC cancer mutations	skin-upper_back-other-lichenoid_keratosis	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-ear-other-nevus_sebaceous	COSMIC cancer mutations	skin-ear-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-adnexal_tumour-syringocystadenoma_papilliferum	COSMIC cancer mutations	skin-adnexal_tumour-syringocystadenoma_papilliferum	5	1	16828	49	FGFR3
1.448e-02	-4.24	skin-breast-other-nevus_sebaceous	COSMIC cancer mutations	skin-breast-other-nevus_sebaceous	5	1	16828	49	FGFR3
1.448e-02	-4.23	PDZ	smart domains	SM00228	143	3	9717	35	PARD3B,PREX2,SHROOM3
1.450e-02	-4.23	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	30	NTRK2
1.451e-02	-4.23	NTRK3 (neurotrophic receptor tyrosine kinase 3)	protein interactions	4916	367	4	19454	50	ABLIM1,GLUD1,TNIK,NTRK2
1.462e-02	-4.23	cellular response to organic substance	biological process	GO:0071310	1716	10	18204	49	RORA,AQP4,GNA14,GABRB1,RYR3,SORBS1,SLC1A3,ATP1A2,ADCY2,SLC1A2
1.475e-02	-4.22	PDZ	prosite domains	PS50106	143	3	12186	44	PREX2,SHROOM3,PARD3B
1.476e-02	-4.22	Ppp1cb (protein phosphatase 1 catalytic subunit beta)	protein interactions	19046	72	2	19454	50	STON2,ABLIM1
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	BMPR1B,PARD3B
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	TNIK,GPM6A
1.499e-02	-4.20	ARF6 (ADP ribosylation factor 6)	protein interactions	382	568	5	19454	50	GLUD1,CACHD1,TNIK,FMN2,SLC1A3
1.500e-02	-4.20	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	8	16828	49	NTRK2,MGAT4C,RORA,RYR3,GABRB1,CTNND2,FGFR3,TNIK
1.508e-02	-4.19	upper_back	COSMIC cancer mutations	upper_back	328	4	16828	49	FGFR3,PARD3B,MACF1,GPC5
1.520e-02	-4.19	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	10	16828	49	FGFR3,SHROOM3,RORA,MACF1,SOX5,ATP1A2,LSAMP,SLC4A4,ATP13A4,GPC5
1.526e-02	-4.18	ovulation cycle	biological process	GO:0042698	70	2	18204	49	GABRB1,BMPR1B
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	RSPO3 (R-spondin 3)	protein interactions	84870	6	1	19454	50	ZNRF3
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	FGF6 (fibroblast growth factor 6)	protein interactions	2251	6	1	19454	50	FGFR3
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	Klhl22 (kelch-like 22)	protein interactions	224023	6	1	19454	50	GLUD1
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	FGF18 (fibroblast growth factor 18)	protein interactions	8817	6	1	19454	50	FGFR3
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	FGF23 (fibroblast growth factor 23)	protein interactions	8074	6	1	19454	50	FGFR3
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.533e-02	-4.18	protein homooligomerization	biological process	GO:0051260	194	3	18204	49	AQP4,RYR3,SLC1A2
1.549e-02	-4.17	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	5	16828	49	NPAS3,MGAT4C,SPARCL1,FGFR3,GABRB1
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	DTNA,ABLIM1,PARD3B
1.555e-02	-4.16	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	4	16828	49	NTM,SORBS1,PARD3B,ADCY2
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.598e-02	-4.14	GPROTEINAQ	prints domains	PR00442	4	1	5227	21	GNA14
1.598e-02	-4.14	ALPHACATENIN	prints domains	PR00805	4	1	5227	21	CTNNA2
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	SFXN5,FBXL7,GLUD1,TNIK,MSI2,HIF3A,NHSL1,MGAT4C,LSAMP,CPE,NTRK2,ABLIM1,FGFR3,STON2,CTNND2,SORBS1,RORA,DTNA,GLI3,GABRB1,RFX4,SPARCL1,ZNRF3,PREX2,SLC1A2,CACHD1,NKAIN3,SOX5,MACF1,NTM,GPC5,SLC4A4,ADCY2,AQP4,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,ATP13A4,RYR3,GPM6A,PAMR1,SLC1A3,ATP1A2,BMPR1B,RANBP3L,NPAS3
1.604e-02	-4.13	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	49	SLC1A3
1.604e-02	-4.13	intracellular water homeostasis	biological process	GO:0009992	6	1	18204	49	AQP4
1.604e-02	-4.13	cellular response to histamine	biological process	GO:0071420	6	1	18204	49	GABRB1
1.604e-02	-4.13	fused antrum stage	biological process	GO:0048165	6	1	18204	49	BMPR1B
1.604e-02	-4.13	mammary gland formation	biological process	GO:0060592	6	1	18204	49	GLI3
1.604e-02	-4.13	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	49	SOX5
1.604e-02	-4.13	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	49	FMN2
1.604e-02	-4.13	optic nerve morphogenesis	biological process	GO:0021631	6	1	18204	49	GLI3
1.609e-02	-4.13	G3BP1 (G3BP stress granule assembly factor 1)	protein interactions	10146	799	6	19454	50	SOX5,MACF1,GLUD1,MSI2,CTNNA2,SORBS1
1.609e-02	-4.13	RIH_dom	interpro domains	IPR000699	6	1	18521	50	RYR3
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY2
1.609e-02	-4.13	RIH_assoc-dom	interpro domains	IPR013662	6	1	18521	50	RYR3
1.609e-02	-4.13	Ins145_P3_rcpt	interpro domains	IPR014821	6	1	18521	50	RYR3
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	GAR_dom_sf	interpro domains	IPR036534	6	1	18521	50	MACF1
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	GAR_dom	interpro domains	IPR003108	6	1	18521	50	MACF1
1.609e-02	-4.13	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	1	18521	50	RYR3
1.609e-02	-4.13	Desmoplakin_SH3	interpro domains	IPR041615	6	1	18521	50	MACF1
1.609e-02	-4.13	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	1	18521	50	RYR3
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	stem cell proliferation	biological process	GO:0072089	72	2	18204	49	GLI3,ZNRF3
1.622e-02	-4.12	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	8	16828	49	FGFR3,CTNND2,TNIK,RYR3,GABRB1,MGAT4C,RORA,NTRK2
1.629e-02	-4.12	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	50	BMPR1B,MACF1,GLI3,FGFR3
1.641e-02	-4.11	Ins145_P3_rec	pfam domains	PF08709	6	1	17795	49	RYR3
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.641e-02	-4.11	RYDR_ITPR	pfam domains	PF01365	6	1	17795	49	RYR3
1.641e-02	-4.11	EF-hand_2	pfam domains	PF09068	6	1	17795	49	DTNA
1.641e-02	-4.11	SH3_10	pfam domains	PF17902	6	1	17795	49	MACF1
1.641e-02	-4.11	Plectin	pfam domains	PF00681	6	1	17795	49	MACF1
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY2
1.641e-02	-4.11	EF-hand_3	pfam domains	PF09069	6	1	17795	49	DTNA
1.641e-02	-4.11	GAS2	pfam domains	PF02187	6	1	17795	49	MACF1
1.641e-02	-4.11	RIH_assoc	pfam domains	PF08454	6	1	17795	49	RYR3
1.652e-02	-4.10	peptide metabolic process	biological process	GO:0006518	73	2	18204	49	SLC1A2,CPE
1.675e-02	-4.09	ABI1 (abl interactor 1)	protein interactions	10006	210	3	19454	50	SLC1A3,NHSL1,SORBS1
1.696e-02	-4.08	CDK6 (cyclin dependent kinase 6)	protein interactions	1021	211	3	19454	50	SOX5,FGFR3,SORBS1
1.705e-02	-4.07	HAD_sf	interpro domains	IPR023214	74	2	18521	50	ATP13A4,ATP1A2
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.716e-02	-4.07	MARCKS (myristoylated alanine rich protein kinase C substrate)	protein interactions	4082	588	5	19454	50	SLC1A3,ABLIM1,DTNA,MACF1,CACHD1
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	SOX5,MSI2
1.717e-02	-4.06	Nedd4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	25489	78	2	19454	50	NTRK2,BMPR1B
1.718e-02	-4.06	Calcium signaling pathway	KEGG pathways	ko04020	181	3	7161	22	RYR3,ADCY2,GNA14
1.718e-02	-4.06	Calcium signaling pathway	KEGG pathways	hsa04020	181	3	7161	22	GNA14,ADCY2,RYR3
1.718e-02	-4.06	DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2)	protein interactions	27000	212	3	19454	50	GLUD1,MACF1,TNIK
1.735e-02	-4.05	collecting_duct_carcinoma	COSMIC cancer mutations	collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-epidermal_nevus	COSMIC cancer mutations	skin-head_neck-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-arm-epidermal_nevus	COSMIC cancer mutations	skin-arm-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	kidney-carcinoma-collecting_duct_carcinoma	COSMIC cancer mutations	kidney-carcinoma-collecting_duct_carcinoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-face-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-face-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-trunk-epidermal_nevus	COSMIC cancer mutations	skin-trunk-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-Bowen_disease	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-Bowen_disease	6	1	16828	49	FGFR3
1.735e-02	-4.05	lentiginous_nevus	COSMIC cancer mutations	lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-benign_melanocytic_nevus-lentiginous_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus-lentiginous_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-abdomen-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-abdomen-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_back-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-lower_back-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-lower_leg-epidermal_nevus	COSMIC cancer mutations	skin-lower_leg-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-upper_leg-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-upper_leg-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-in_situ_epithelial_neoplasm-actinic_keratosis	COSMIC cancer mutations	skin-in_situ_epithelial_neoplasm-actinic_keratosis	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.735e-02	-4.05	skin-adnexal_tumour-trichoblastoma	COSMIC cancer mutations	skin-adnexal_tumour-trichoblastoma	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-epidermal_nevus	COSMIC cancer mutations	skin-epidermal_nevus	6	1	16828	49	FGFR3
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-flank-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-flank-other-seborrhoeic_keratosis	6	1	16828	49	FGFR3
1.738e-02	-4.05	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	30	NTRK2
1.738e-02	-4.05	amino acid biosynthetic process	biological process	GO:0008652	75	2	18204	49	GLUD1,SLC1A3
1.747e-02	-4.05	small molecule binding	molecular function	GO:0036094	6197	24	18094	48	SLC1A2,SPARCL1,GNA14,MGAT4C,ABLIM1,ATP13A4,FGFR3,GLUD1,PAMR1,BMPR1B,GLI3,RORA,RYR3,GLIS3,NTRK2,ZNRF3,PITPNC1,TNIK,CPE,SLC1A3,ADCY2,ATP1A2,MACF1,DTNA
1.751e-02	-4.05	presynaptic active zone	cellular component	GO:0048786	79	2	19108	49	GPM6A,GABRB1
1.759e-02	-4.04	FBXO45 (F-box protein 45)	protein interactions	200933	79	2	19454	50	CTNNA2,SHROOM3
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	TNIK,NTRK2,NHSL1
1.765e-02	-4.04	cytoskeleton organization	biological process	GO:0007010	1251	8	18204	49	SORBS1,TNIK,CTNNA2,ABLIM1,PARD3B,FMN2,SHROOM3,MACF1
1.766e-02	-4.04	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	19	16828	49	GPC5,SLC4A4,ATP13A4,CTNND2,CACHD1,ATP1A2,FMN2,MACF1,ABLIM1,FGFR3,SHROOM3,PARD3B,PAMR1,PREX2,MGAT4C,SLC1A2,RORA,GLI3,RFX4
1.769e-02	-4.03	bone-tibia-chondrosarcoma	COSMIC cancer mutations	bone-tibia-chondrosarcoma	70	2	16828	49	CPE,RANBP3L
1.774e-02	-4.03	calcium ion transmembrane transport	biological process	GO:0070588	205	3	18204	49	GPM6A,CACHD1,RYR3
1.779e-02	-4.03	Neuronal System	REACTOME pathways	R-HSA-112316	349	4	10285	30	GABRB1,ADCY2,SLC1A3,SLC1A2
1.782e-02	-4.03	alpha-beta T cell differentiation	biological process	GO:0046632	76	2	18204	49	GLI3,RORA
1.785e-02	-4.03	nitrogen compound transport	biological process	GO:0071705	1507	9	18204	49	NTRK2,ATP13A4,SLC1A2,SLC1A3,MACF1,CPE,GLI3,RANBP3L,FMN2
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	FGF5 (fibroblast growth factor 5)	protein interactions	2250	7	1	19454	50	FGFR3
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.811e-02	-4.01	Leucine Dehydrogenase, chain A, domain 1	gene3d domains	3.40.50.10860	6	1	14470	44	GLUD1
1.811e-02	-4.01	Plakin repeat	gene3d domains	3.90.1290.10	6	1	14470	44	MACF1
1.811e-02	-4.01	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	1	14470	44	RYR3
1.811e-02	-4.01	Gas2-like domain	gene3d domains	3.30.920.20	6	1	14470	44	MACF1
1.815e-02	-4.01	alveolar	COSMIC cancer mutations	alveolar	2414	13	16828	49	MACF1,FMN2,PARD3B,FGFR3,NPAS3,SORBS1,RYR3,PREX2,SLC1A3,PAMR1,NHSL1,ZNRF3,SPARCL1
1.815e-02	-4.01	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	13	16828	49	NHSL1,PAMR1,PREX2,SLC1A3,SPARCL1,ZNRF3,NPAS3,SORBS1,RYR3,FMN2,MACF1,FGFR3,PARD3B
1.815e-02	-4.01	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	5	ADCY2
1.821e-02	-4.01	SMAD binding	molecular function	GO:0046332	78	2	18094	48	BMPR1B,RANBP3L
1.826e-02	-4.00	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	3	19454	50	ABLIM1,RORA,NKAIN3
1.827e-02	-4.00	neural retina development	biological process	GO:0003407	77	2	18204	49	NTRK2,GPM6A
1.827e-02	-4.00	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	49	NTRK2,MACF1
1.843e-02	-3.99	L-leucine binding	molecular function	GO:0070728	7	1	18094	48	GLUD1
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.865e-02	-3.98	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	4	18521	50	NTRK2,BMPR1B,TNIK,FGFR3
1.869e-02	-3.98	ventral spinal cord interneuron specification	biological process	GO:0021521	7	1	18204	49	GLI3
1.869e-02	-3.98	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	49	FMN2
1.869e-02	-3.98	forebrain dorsal/ventral pattern formation	biological process	GO:0021798	7	1	18204	49	GLI3
1.869e-02	-3.98	negative regulation of non-canonical Wnt signaling pathway	biological process	GO:2000051	7	1	18204	49	ZNRF3
1.869e-02	-3.98	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	49	RYR3
1.869e-02	-3.98	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	49	CTNNA2
1.869e-02	-3.98	hindgut morphogenesis	biological process	GO:0007442	7	1	18204	49	GLI3
1.869e-02	-3.98	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	49	FMN2
1.869e-02	-3.98	cell fate specification involved in pattern specification	biological process	GO:0060573	7	1	18204	49	GLI3
1.869e-02	-3.98	forebrain radial glial cell differentiation	biological process	GO:0021861	7	1	18204	49	GLI3
1.872e-02	-3.98	positive regulation of osteoblast differentiation	biological process	GO:0045669	78	2	18204	49	GLI3,BMPR1B
1.872e-02	-3.98	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	49	SLC1A2,SORBS1
1.872e-02	-3.98	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	2	18204	49	SLC4A4,SORBS1
1.873e-02	-3.98	response to nitrogen compound	biological process	GO:1901698	1021	7	18204	49	GNA14,GABRB1,SLC1A3,RYR3,SORBS1,SLC1A2,TNIK
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.875e-02	-3.98	Plakin_repeat_sf	interpro domains	IPR035915	7	1	18521	50	MACF1
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.875e-02	-3.98	Aquaporin_transptr	interpro domains	IPR034294	7	1	18521	50	AQP4
1.875e-02	-3.98	Plectin_repeat	interpro domains	IPR001101	7	1	18521	50	MACF1
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.882e-02	-3.97	HAD-like_sf	interpro domains	IPR036412	78	2	18521	50	ATP13A4,ATP1A2
1.897e-02	-3.96	human chr9q21.2	chromosome location	human chr9q21.2	10	1	26134	50	GNA14
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.897e-02	-3.96	human chr14q31.1	chromosome location	human chr14q31.1	10	1	26134	50	STON2
1.902e-02	-3.96	testis	COSMIC cancer mutations	testis	733	6	16828	49	PREX2,TNIK,FGFR3,NTRK2,BMPR1B,MACF1
1.909e-02	-3.96	eye development	biological process	GO:0001654	381	4	18204	49	GLI3,NTRK2,BMPR1B,GPM6A
1.912e-02	-3.96	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	49	SPARCL1
1.912e-02	-3.96	TGF_beta_GS	pfam domains	PF08515	7	1	17795	49	BMPR1B
1.914e-02	-3.96	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_II	73	2	16828	49	FGFR3,MACF1
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	ATP1A2,SORBS1
1.930e-02	-3.95	DNM3 (dynamin 3)	protein interactions	26052	83	2	19454	50	GPM6A,FGFR3
1.930e-02	-3.95	SYT1 (synaptotagmin 1)	protein interactions	6857	83	2	19454	50	STON2,GPM6A
1.943e-02	-3.94	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	ATP13A4,PREX2,GPC5,SLC1A2,MACF1,GLI3,FMN2
1.943e-02	-3.94	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	7	16828	49	FMN2,MACF1,GLI3,ATP13A4,PREX2,GPC5,SLC1A2
1.964e-02	-3.93	oligodendroglioma_Grade_II	COSMIC cancer mutations	oligodendroglioma_Grade_II	74	2	16828	49	FGFR3,MACF1
1.972e-02	-3.93	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_T_cell_leukaemia	739	6	16828	49	GABRB1,SHROOM3,FGFR3,ZNRF3,PREX2,MGAT4C
1.972e-02	-3.93	acute_lymphoblastic_T_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_T_cell_leukaemia	739	6	16828	49	GABRB1,FGFR3,SHROOM3,ZNRF3,MGAT4C,PREX2
1.974e-02	-3.93	Tyr_kinase_cat_dom	interpro domains	IPR020635	80	2	18521	50	NTRK2,FGFR3
1.976e-02	-3.92	visual system development	biological process	GO:0150063	385	4	18204	49	GPM6A,NTRK2,BMPR1B,GLI3
1.985e-02	-3.92	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	3	19454	50	GPM6A,MACF1,ABLIM1
1.989e-02	-3.92	central_nervous_system-brain-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_III	1419	9	16828	49	CACHD1,GNA14,GABRB1,FGFR3,SHROOM3,ADCY2,GPC5,PAMR1,RYR3
1.991e-02	-3.92	FGFR1 (fibroblast growth factor receptor 1)	protein interactions	2260	611	5	19454	50	NHSL1,FGFR3,ABLIM1,DTNA,TNIK
1.993e-02	-3.92	PITRANSFER	prints domains	PR00391	5	1	5227	21	PITPNC1
1.993e-02	-3.92	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	21	SLC4A4
1.996e-02	-3.91	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	19	16828	49	RYR3,SORBS1,CTNND2,NPAS3,PARD3B,FGFR3,GLIS3,MACF1,FMN2,ZNRF3,ADCY2,SPARCL1,SLC1A3,PREX2,PAMR1,NHSL1,AQP4,GLI3,RORA
2.009e-02	-3.91	adult locomotory behavior	biological process	GO:0008344	81	2	18204	49	PREX2,ATP1A2
2.021e-02	-3.90	skin-benign_melanocytic_nevus-compound	COSMIC cancer mutations	skin-benign_melanocytic_nevus-compound	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-other-nevus_sebaceous	COSMIC cancer mutations	skin-other-nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-benign_melanocytic_nevus-intradermal	COSMIC cancer mutations	skin-benign_melanocytic_nevus-intradermal	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-shoulder-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-shoulder-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-chest-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-chest-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	trichilemmoma	COSMIC cancer mutations	trichilemmoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	nevus_sebaceous	COSMIC cancer mutations	nevus_sebaceous	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-neck-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-neck-other-seborrhoeic_keratosis	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-face-adnexal_tumour-malignant_adnexal_tumour	COSMIC cancer mutations	skin-face-adnexal_tumour-malignant_adnexal_tumour	7	1	16828	49	FGFR3
2.021e-02	-3.90	urinary_tract-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma-transitional_cell_carcinoma	7	1	16828	49	FGFR3
2.021e-02	-3.90	skin-adnexal_tumour-trichilemmoma	COSMIC cancer mutations	skin-adnexal_tumour-trichilemmoma	7	1	16828	49	FGFR3
2.023e-02	-3.90	Adherens junction	KEGG pathways	ko04520	72	2	7161	22	SORBS1,CTNNA2
2.023e-02	-3.90	Adherens junction	KEGG pathways	hsa04520	72	2	7161	22	SORBS1,CTNNA2
2.025e-02	-3.90	FGFR3b ligand binding and activation	REACTOME pathways	R-HSA-190371	7	1	10285	30	FGFR3
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.038e-02	-3.89	CCK (cholecystokinin)	protein interactions	885	8	1	19454	50	CPE
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.044e-02	-3.89	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	25	16828	49	SPARCL1,PAMR1,PREX2,SLC1A3,RORA,DTNA,GLI3,SLC4A4,NPAS3,CACHD1,ATP1A2,NKAIN3,MACF1,SOX5,ADCY2,RYR3,CTNND2,STON2,ATP13A4,GNA14,ABLIM1,FGFR3,SHROOM3,NTRK2,GLIS3
2.053e-02	-3.89	contractile actin filament bundle	cellular component	GO:0097517	86	2	19108	49	SORBS1,ABLIM1
2.053e-02	-3.89	stress fiber	cellular component	GO:0001725	86	2	19108	49	SORBS1,ABLIM1
2.055e-02	-3.88	receptor complex	cellular component	GO:0043235	409	4	19108	49	NTRK2,GABRB1,BMPR1B,FGFR3
2.063e-02	-3.88	EGLN1 (egl-9 family hypoxia inducible factor 1)	protein interactions	54583	86	2	19454	50	HIF3A,FGFR3
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	SORBS1,GPM6A
2.067e-02	-3.88	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	5	16828	49	TNIK,FGFR3,BMPR1B,FMN2,NTRK2
2.075e-02	-3.88	response to oxygen-containing compound	biological process	GO:1901700	1546	9	18204	49	SLC1A2,ADCY2,RYR3,SLC1A3,SORBS1,ATP1A2,GNA14,GABRB1,RORA
2.078e-02	-3.87	sensory system development	biological process	GO:0048880	391	4	18204	49	GPM6A,BMPR1B,NTRK2,GLI3
2.082e-02	-3.87	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	5	16828	49	TNIK,FGFR3,BMPR1B,FMN2,NTRK2
2.101e-02	-3.86	EF_hand_dom	interpro domains	IPR002048	218	3	18521	50	MACF1,SPARCL1,RYR3
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.105e-02	-3.86	glutamatergic synapse	cellular component	GO:0098978	412	4	19108	49	SLC1A2,GPM6A,SPARCL1,TNIK
2.106e-02	-3.86	Muscle contraction	REACTOME pathways	R-HSA-397014	204	3	10285	30	RYR3,SORBS1,ATP1A2
2.119e-02	-3.85	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	7	18204	49	SLC1A3,SORBS1,RYR3,ADCY2,SLC1A2,RORA,GNA14
2.125e-02	-3.85	HAD superfamily/HAD-like	gene3d domains	3.40.50.1000	74	2	14470	44	ATP13A4,ATP1A2
2.127e-02	-3.85	BICD1 (BICD cargo adaptor 1)	protein interactions	636	230	3	19454	50	SHROOM3,SORBS1,TNIK
2.127e-02	-3.85	DST (dystonin)	protein interactions	667	230	3	19454	50	TNIK,ATP1A2,NTRK2
2.129e-02	-3.85	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	2	7161	22	ATP1A2,ADCY2
2.129e-02	-3.85	Thyroid hormone synthesis	KEGG pathways	ko04918	74	2	7161	22	ATP1A2,ADCY2
2.130e-02	-3.85	leg	COSMIC cancer mutations	leg	969	7	16828	49	SHROOM3,FGFR3,NTM,FMN2,HIF3A,ATP13A4,SLC4A4
2.134e-02	-3.85	insulin processing	biological process	GO:0030070	8	1	18204	49	CPE
2.134e-02	-3.85	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	49	RORA
2.134e-02	-3.85	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	49	ATP1A2
2.134e-02	-3.85	glutamate catabolic process	biological process	GO:0006538	8	1	18204	49	GLUD1
2.134e-02	-3.85	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	49	RORA
2.134e-02	-3.85	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	49	CTNNA2
2.134e-02	-3.85	hindgut development	biological process	GO:0061525	8	1	18204	49	GLI3
2.134e-02	-3.85	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	49	SLC1A3
2.134e-02	-3.85	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	49	RORA
2.134e-02	-3.85	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	49	FMN2
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY2
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY2
2.140e-02	-3.84	Plakin	interpro domains	IPR043197	8	1	18521	50	MACF1
2.142e-02	-3.84	GAS2	smart domains	SM00243	6	1	9717	35	MACF1
2.147e-02	-3.84	GLYPICAN	prosite domains	PS01207	6	1	12186	44	GPC5
2.147e-02	-3.84	GAR	prosite domains	PS51460	6	1	12186	44	MACF1
2.151e-02	-3.84	L-amino acid transport	biological process	GO:0015807	84	2	18204	49	SLC1A3,SLC1A2
2.151e-02	-3.84	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	49	NKAIN3,ATP1A2
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	BMPR1B,TNIK
2.153e-02	-3.84	HSPG2 (heparan sulfate proteoglycan 2)	protein interactions	3339	88	2	19454	50	GLI3,GPC5
2.153e-02	-3.84	Ig_sub	interpro domains	IPR003599	394	4	18521	50	FGFR3,NTRK2,NTM,LSAMP
2.175e-02	-3.83	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	5	ADCY2
2.175e-02	-3.83	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	5	ADCY2
2.177e-02	-3.83	cAMP signaling pathway	KEGG pathways	ko04024	198	3	7161	22	GLI3,ADCY2,ATP1A2
2.177e-02	-3.83	cAMP signaling pathway	KEGG pathways	hsa04024	198	3	7161	22	ADCY2,GLI3,ATP1A2
2.182e-02	-3.82	VHP	pfam domains	PF02209	8	1	17795	49	ABLIM1
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY2
2.184e-02	-3.82	Gastric acid secretion	KEGG pathways	ko04971	75	2	7161	22	ATP1A2,ADCY2
2.184e-02	-3.82	Gastric acid secretion	KEGG pathways	hsa04971	75	2	7161	22	ADCY2,ATP1A2
2.186e-02	-3.82	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	49	PARD3B,STON2,FMN2,SLC4A4,PREX2
2.199e-02	-3.82	oligodendrocyte differentiation	biological process	GO:0048709	85	2	18204	49	NTRK2,GLI3
2.199e-02	-3.82	regulation of smoothened signaling pathway	biological process	GO:0008589	85	2	18204	49	GLI3,RORA
2.212e-02	-3.81	RHOJ (ras homolog family member J)	protein interactions	57381	628	5	19454	50	BMPR1B,MACF1,CACHD1,SLC1A3,STON2
2.246e-02	-3.80	Tmod3 (tropomodulin 3)	protein interactions	50875	90	2	19454	50	STON2,ABLIM1
2.247e-02	-3.80	central nervous system neuron development	biological process	GO:0021954	86	2	18204	49	GABRB1,NTRK2
2.249e-02	-3.79	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	3	19454	50	MACF1,DTNA,NTRK2
2.285e-02	-3.78	astrocyte end-foot	cellular component	GO:0097450	9	1	19108	49	AQP4
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	GUSBP1 (GUSB pseudogene 1)	protein interactions	728411	9	1	19454	50	FGFR3
2.290e-02	-3.78	KLB (klotho beta)	protein interactions	152831	9	1	19454	50	FGFR3
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	TNIK,SORBS1
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	GPM6A,NTM
2.296e-02	-3.77	dorsal/ventral pattern formation	biological process	GO:0009953	87	2	18204	49	GLI3,BMPR1B
2.306e-02	-3.77	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-ureter-carcinoma-transitional_cell_carcinoma	8	1	16828	49	FGFR3
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.306e-02	-3.77	junctional	COSMIC cancer mutations	junctional	8	1	16828	49	FGFR3
2.306e-02	-3.77	actinic_keratosis	COSMIC cancer mutations	actinic_keratosis	8	1	16828	49	FGFR3
2.306e-02	-3.77	cervical_intraepithelial_neoplasia_Grade_I	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_I	8	1	16828	49	FGFR3
2.306e-02	-3.77	trichoblastoma	COSMIC cancer mutations	trichoblastoma	8	1	16828	49	FGFR3
2.311e-02	-3.77	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	REACTOME pathways	R-HSA-434316	8	1	10285	30	GNA14
2.311e-02	-3.77	Free fatty acids regulate insulin secretion	REACTOME pathways	R-HSA-400451	8	1	10285	30	GNA14
2.311e-02	-3.77	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	30	GPC5
2.318e-02	-3.76	skin-leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-leg-malignant_melanoma-superficial_spreading	210	3	16828	49	SLC4A4,ATP13A4,NTM
2.325e-02	-3.76	forearm	COSMIC cancer mutations	forearm	81	2	16828	49	PREX2,FGFR3
2.329e-02	-3.76	actomyosin	cellular component	GO:0042641	92	2	19108	49	ABLIM1,SORBS1
2.339e-02	-3.76	POTEI (POTE ankyrin domain family member I)	protein interactions	653269	92	2	19454	50	FGFR3,DTNA
2.339e-02	-3.76	FNTA (farnesyltransferase, CAAX box, subunit alpha)	protein interactions	2339	92	2	19454	50	FGFR3,TNIK
2.356e-02	-3.75	cellular response to chemical stimulus	biological process	GO:0070887	2411	12	18204	49	NTRK2,RYR3,SORBS1,ATP1A2,SLC1A2,SLC1A3,ADCY2,AQP4,RORA,FMN2,GNA14,GABRB1
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	BMPR1B,ABLIM1
2.388e-02	-3.73	ACTIVIN2R	prints domains	PR00653	6	1	5227	21	BMPR1B
2.388e-02	-3.73	hand	COSMIC cancer mutations	hand	566	5	16828	49	HIF3A,SLC4A4,PREX2,FGFR3,SHROOM3
2.397e-02	-3.73	semicircular canal development	biological process	GO:0060872	9	1	18204	49	GLI3
2.397e-02	-3.73	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	49	ATP1A2
2.397e-02	-3.73	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	49	CTNNA2
2.397e-02	-3.73	cranial suture morphogenesis	biological process	GO:0060363	9	1	18204	49	GLI3
2.397e-02	-3.73	phospholipase C-activating dopamine receptor signaling pathway	biological process	GO:0060158	9	1	18204	49	GNA14
2.397e-02	-3.73	embryonic neurocranium morphogenesis	biological process	GO:0048702	9	1	18204	49	GLI3
2.397e-02	-3.73	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	49	CTNNA2
2.397e-02	-3.73	polyamine transmembrane transport	biological process	GO:1902047	9	1	18204	49	ATP13A4
2.397e-02	-3.73	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	49	RYR3
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.404e-02	-3.73	Aminoacid_DH-like_N_sf	interpro domains	IPR046346	9	1	18521	50	GLUD1
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.405e-02	-3.73	central_nervous_system-brain-atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	central_nervous_system-brain-atypical_teratoid-rhabdoid_tumour	213	3	16828	49	FGFR3,GABRB1,FMN2
2.405e-02	-3.73	atypical_teratoid-rhabdoid_tumour	COSMIC cancer mutations	atypical_teratoid-rhabdoid_tumour	213	3	16828	49	GABRB1,FGFR3,FMN2
2.407e-02	-3.73	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	44	ABLIM1
2.411e-02	-3.73	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	49	RYR3,ATP1A2,ADCY2,TNIK,FGFR3,PREX2
2.412e-02	-3.72	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	19	16828	49	FGFR3,PARD3B,GLIS3,FMN2,MACF1,RYR3,CTNND2,SORBS1,NPAS3,RORA,GLI3,ADCY2,SPARCL1,ZNRF3,AQP4,PAMR1,NHSL1,SLC1A3,PREX2
2.430e-02	-3.72	protein binding	molecular function	GO:0005515	13983	43	18094	48	GPC5,NTRK2,FMN2,ZNRF3,PITPNC1,SOX5,TNIK,CPE,SLC1A3,AQP4,MACF1,ATP1A2,ADCY2,DTNA,GLI3,SFXN5,RORA,RFX4,HIF3A,FBXL7,GABRB1,GLIS3,RYR3,SORBS1,PARD3B,LSAMP,NTM,FGFR3,STON2,GLUD1,BMPR1B,SLC1A2,RANBP3L,SPARCL1,MSI2,GNA14,GPM6A,CTNNA2,NPAS3,SHROOM3,CTNND2,ABLIM1,SLC4A4
2.435e-02	-3.72	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	50	FGFR3,NTRK2
2.435e-02	-3.72	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	2	19454	50	TNIK,ABLIM1
2.452e-02	-3.71	Activin_recp	pfam domains	PF01064	9	1	17795	49	BMPR1B
2.452e-02	-3.71	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	49	RFX4
2.452e-02	-3.71	Band_3_cyto	pfam domains	PF07565	9	1	17795	49	SLC4A4
2.459e-02	-3.71	human chr5p15.1	chromosome location	human chr5p15.1	13	1	26134	50	FBXL7
2.469e-02	-3.70	neck	COSMIC cancer mutations	neck	1231	8	16828	49	PREX2,ATP13A4,ADCY2,GPC5,CTNND2,ATP1A2,FGFR3,SHROOM3
2.490e-02	-3.69	transmembrane transporter complex	cellular component	GO:1902495	434	4	19108	49	ATP1A2,RYR3,GABRB1,CACHD1
2.495e-02	-3.69	GS	smart domains	SM00467	7	1	9717	35	BMPR1B
2.495e-02	-3.69	PLEC	smart domains	SM00250	7	1	9717	35	MACF1
2.495e-02	-3.69	axon	cellular component	GO:0030424	650	5	19108	49	GPM6A,NTRK2,SLC1A2,CTNNA2,DTNA
2.501e-02	-3.69	GS	prosite domains	PS51256	7	1	12186	44	BMPR1B
2.519e-02	-3.68	chemical synaptic transmission	biological process	GO:0007268	415	4	18204	49	SLC1A2,GABRB1,SLC1A3,DTNA
2.519e-02	-3.68	anterograde trans-synaptic signaling	biological process	GO:0098916	415	4	18204	49	DTNA,SLC1A2,GABRB1,SLC1A3
2.521e-02	-3.68	actin filament bundle	cellular component	GO:0032432	96	2	19108	49	ABLIM1,SORBS1
2.523e-02	-3.68	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	3	16828	49	MGAT4C,DTNA,RFX4
2.534e-02	-3.68	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	5	ADCY2
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	SERPINB11 (serpin family B member 11)	protein interactions	89778	10	1	19454	50	CPE
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.547e-02	-3.67	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	7	19454	50	MACF1,SORBS1,PITPNC1,ABLIM1,SHROOM3,PARD3B,NHSL1
2.548e-02	-3.67	protein tetramerization	biological process	GO:0051262	92	2	18204	49	AQP4,RYR3
2.581e-02	-3.66	Tpm1 (tropomyosin 1, alpha)	protein interactions	22003	97	2	19454	50	STON2,ABLIM1
2.585e-02	-3.66	ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase)	protein interactions	25	248	3	19454	50	CTNND2,STON2,SORBS1
2.589e-02	-3.65	shoulder	COSMIC cancer mutations	shoulder	387	4	16828	49	FGFR3,CPE,PREX2,MACF1
2.591e-02	-3.65	in_situ_epithelial_neoplasm	COSMIC cancer mutations	in_situ_epithelial_neoplasm	9	1	16828	49	FGFR3
2.591e-02	-3.65	epidermal_nevus	COSMIC cancer mutations	epidermal_nevus	9	1	16828	49	FGFR3
2.591e-02	-3.65	Bowen_disease	COSMIC cancer mutations	Bowen_disease	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-other-seborrhoeic_keratosis	COSMIC cancer mutations	skin-other-seborrhoeic_keratosis	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	compound	COSMIC cancer mutations	compound	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	COSMIC cancer mutations	ovary-low_malignant_potential_(borderline)_tumour-Brenner_tumour	9	1	16828	49	FGFR3
2.591e-02	-3.65	skin-benign_melanocytic_nevus-congenital	COSMIC cancer mutations	skin-benign_melanocytic_nevus-congenital	9	1	16828	49	FGFR3
2.616e-02	-3.64	muscle contraction	biological process	GO:0006936	238	3	18204	49	DTNA,ATP1A2,RYR3
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.622e-02	-3.64	polyamine transmembrane transporter activity	molecular function	GO:0015203	10	1	18094	48	ATP13A4
2.622e-02	-3.64	neurotrophin binding	molecular function	GO:0043121	10	1	18094	48	NTRK2
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	GPM6A,LSAMP
2.646e-02	-3.63	human chr2p13.2	chromosome location	human chr2p13.2	14	1	26134	50	SFXN5
2.648e-02	-3.63	LPA receptor mediated events	Pathway Interaction DB	lysophospholipid_pathway	65	2	2226	9	GNA14,ADCY2
2.660e-02	-3.63	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	49	SOX5
2.660e-02	-3.63	retinal rod cell development	biological process	GO:0046548	10	1	18204	49	NTRK2
2.660e-02	-3.63	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	49	NTRK2
2.660e-02	-3.63	response to histamine	biological process	GO:0034776	10	1	18204	49	GABRB1
2.660e-02	-3.63	spinal cord motor neuron cell fate specification	biological process	GO:0021520	10	1	18204	49	GLI3
2.660e-02	-3.63	establishment of centrosome localization	biological process	GO:0051660	10	1	18204	49	PARD3B
2.660e-02	-3.63	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	49	RYR3
2.660e-02	-3.63	regulation of bone development	biological process	GO:1903010	10	1	18204	49	GLI3
2.660e-02	-3.63	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	49	NTRK2
2.660e-02	-3.63	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	49	ADCY2
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_motif	interpro domains	IPR016093	10	1	18521	50	RYR3
2.668e-02	-3.62	MIP_CS	interpro domains	IPR022357	10	1	18521	50	AQP4
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	MIR_dom_sf	interpro domains	IPR036300	10	1	18521	50	RYR3
2.683e-02	-3.62	ATPase-coupled transmembrane transporter activity	molecular function	GO:0042626	96	2	18094	48	ATP13A4,ATP1A2
2.698e-02	-3.61	growth	biological process	GO:0040007	424	4	18204	49	GLI3,FGFR3,SLC1A2,BMPR1B
2.698e-02	-3.61	developmental growth	biological process	GO:0048589	424	4	18204	49	BMPR1B,FGFR3,GLI3,SLC1A2
2.719e-02	-3.60	Tyr_kinase_AS	interpro domains	IPR008266	95	2	18521	50	FGFR3,NTRK2
2.720e-02	-3.60	MIR	pfam domains	PF02815	10	1	17795	49	RYR3
2.720e-02	-3.60	HCO3_cotransp	pfam domains	PF00955	10	1	17795	49	SLC4A4
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	GPM6A,ATP1A2
2.731e-02	-3.60	SUFU (SUFU negative regulator of hedgehog signaling)	protein interactions	51684	100	2	19454	50	GLIS3,GLI3
2.735e-02	-3.60	RHOG (ras homolog family member G)	protein interactions	391	902	6	19454	50	MACF1,GLUD1,DTNA,STON2,PREX2,FMN2
2.758e-02	-3.59	Insulin secretion	KEGG pathways	hsa04911	85	2	7161	22	ATP1A2,ADCY2
2.769e-02	-3.59	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	3	16828	49	RFX4,MGAT4C,DTNA
2.781e-02	-3.58	CLEC4A (C-type lectin domain family 4 member A)	protein interactions	50856	101	2	19454	50	FGFR3,CTNNA2
2.786e-02	-3.58	clathrin coat of endocytic vesicle	cellular component	GO:0030128	11	1	19108	49	STON2
2.786e-02	-3.58	AP-2 adaptor complex	cellular component	GO:0030122	11	1	19108	49	STON2
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	CCDC17 (coiled-coil domain containing 17)	protein interactions	149483	11	1	19454	50	FGFR3
2.792e-02	-3.58	NEUROD4 (neuronal differentiation 4)	protein interactions	58158	11	1	19454	50	GABRB1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	NTS (neurotensin)	protein interactions	4922	11	1	19454	50	CPE
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	1	19454	50	ADCY2
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.810e-02	-3.57	nerve development	biological process	GO:0021675	97	2	18204	49	SLC1A3,GLI3
2.810e-02	-3.57	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	49	SLC1A3,SLC1A2
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.846e-02	-3.56	VHP	smart domains	SM00153	8	1	9717	35	ABLIM1
2.847e-02	-3.56	regulation of synapse organization	biological process	GO:0050807	246	3	18204	49	CTNNA2,NTRK2,GPM6A
2.847e-02	-3.56	positive regulation of neurogenesis	biological process	GO:0050769	246	3	18204	49	NTRK2,MACF1,GLI3
2.853e-02	-3.56	HP	prosite domains	PS51089	8	1	12186	44	ABLIM1
2.865e-02	-3.55	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	46	16828	49	TNIK,MSI2,SFXN5,GLUD1,FBXL7,LSAMP,HIF3A,MGAT4C,ABLIM1,FGFR3,CPE,NTRK2,CTNND2,SORBS1,STON2,GABRB1,RFX4,RORA,GLI3,DTNA,SLC1A2,SPARCL1,ZNRF3,PREX2,NTM,CACHD1,SOX5,MACF1,GPC5,SLC4A4,ADCY2,PITPNC1,GNA14,SHROOM3,PARD3B,GLIS3,FMN2,RYR3,ATP13A4,GPM6A,PAMR1,SLC1A3,RANBP3L,ATP1A2,BMPR1B,NPAS3
2.875e-02	-3.55	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervix-in_situ_neoplasm-cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	renal_cell_carcinoma_unclassified	COSMIC cancer mutations	renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	intradermal	COSMIC cancer mutations	intradermal	10	1	16828	49	FGFR3
2.875e-02	-3.55	lung-carcinoma-pleomorphic_carcinoma	COSMIC cancer mutations	lung-carcinoma-pleomorphic_carcinoma	10	1	16828	49	FGFR3
2.875e-02	-3.55	cervical_intraepithelial_neoplasia_Grade_III	COSMIC cancer mutations	cervical_intraepithelial_neoplasia_Grade_III	10	1	16828	49	FGFR3
2.875e-02	-3.55	kidney-carcinoma-renal_cell_carcinoma_unclassified	COSMIC cancer mutations	kidney-carcinoma-renal_cell_carcinoma_unclassified	10	1	16828	49	FGFR3
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.880e-02	-3.55	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	30	SLC4A4
2.880e-02	-3.55	Acetylcholine regulates insulin secretion	REACTOME pathways	R-HSA-399997	10	1	10285	30	GNA14
2.880e-02	-3.55	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	30	ADCY2
2.880e-02	-3.55	Signaling by FGFR3 fusions in cancer	REACTOME pathways	R-HSA-8853334	10	1	10285	30	FGFR3
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.881e-02	-3.55	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	34	16828	49	ATP1A2,CACHD1,MACF1,SOX5,NKAIN3,BMPR1B,RANBP3L,GPC5,SLC4A4,GLI3,RORA,GABRB1,PREX2,PAMR1,NTRK2,GLIS3,FMN2,GNA14,SHROOM3,PARD3B,FGFR3,STON2,RYR3,SORBS1,CTNND2,FBXL7,MSI2,TNIK,HIF3A,ADCY2,MGAT4C,PITPNC1,NHSL1,LSAMP
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	BMPR1B,GPM6A
2.885e-02	-3.55	inorganic ion homeostasis	biological process	GO:0098771	433	4	18204	49	ATP13A4,RYR3,SLC1A3,ATP1A2
2.892e-02	-3.54	Glucose-Alanine Cycle	SMPDB pathways	SMP0000127	8	1	1369	5	GLUD1
2.892e-02	-3.54	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	5	ADCY2
2.892e-02	-3.54	Bile Acid Indirect Signalling Pathway	SMPDB pathways	SMP0086851	8	1	1369	5	FGFR3
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A2,SLC1A3
2.894e-02	-3.54	Ig-like_dom	interpro domains	IPR007110	432	4	18521	50	FGFR3,NTM,LSAMP,NTRK2
2.916e-02	-3.54	monoatomic ion channel activity	molecular function	GO:0005216	441	4	18094	48	GPM6A,GABRB1,CACHD1,RYR3
2.917e-02	-3.53	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	16	16828	49	FMN2,MACF1,GLIS3,ATP1A2,FGFR3,SHROOM3,STON2,ATP13A4,GPC5,CTNND2,RFX4,GABRB1,MGAT4C,PITPNC1,PREX2,ADCY2
2.920e-02	-3.53	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	4	19454	50	MACF1,DTNA,FMN2,CTNND2
2.920e-02	-3.53	FGFR4 (fibroblast growth factor receptor 4)	protein interactions	2264	455	4	19454	50	SORBS1,TNIK,GLUD1,ABLIM1
2.922e-02	-3.53	cell fate commitment involved in pattern specification	biological process	GO:0060581	11	1	18204	49	GLI3
2.922e-02	-3.53	glutamate secretion	biological process	GO:0014047	11	1	18204	49	NTRK2
2.922e-02	-3.53	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	49	ATP1A2
2.922e-02	-3.53	ventral spinal cord interneuron fate commitment	biological process	GO:0060579	11	1	18204	49	GLI3
2.922e-02	-3.53	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	49	ATP1A2
2.922e-02	-3.53	lactone metabolic process	biological process	GO:1901334	11	1	18204	49	ATP1A2
2.922e-02	-3.53	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	49	BMPR1B
2.922e-02	-3.53	polyamine transport	biological process	GO:0015846	11	1	18204	49	ATP13A4
2.922e-02	-3.53	thymocyte apoptotic process	biological process	GO:0070242	11	1	18204	49	GLI3
2.922e-02	-3.53	cellular response to caffeine	biological process	GO:0071313	11	1	18204	49	RYR3
2.927e-02	-3.53	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	30	LSAMP,NTM
2.931e-02	-3.53	Ran_bind_dom	interpro domains	IPR000156	11	1	18521	50	RANBP3L
2.931e-02	-3.53	RanBP1-like	interpro domains	IPR045255	11	1	18521	50	RANBP3L
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.941e-02	-3.53	GABAergic synapse	KEGG pathways	ko04727	88	2	7161	22	ADCY2,GABRB1
2.941e-02	-3.53	GABAergic synapse	KEGG pathways	hsa04727	88	2	7161	22	ADCY2,GABRB1
2.988e-02	-3.51	Adap_comp_sub	pfam domains	PF00928	11	1	17795	49	STON2
2.988e-02	-3.51	PAS_11	pfam domains	PF14598	11	1	17795	49	HIF3A
2.988e-02	-3.51	Ran_BP1	pfam domains	PF00638	11	1	17795	49	RANBP3L
2.997e-02	-3.51	calcium ion transport	biological process	GO:0006816	251	3	18204	49	GPM6A,CACHD1,RYR3
3.000e-02	-3.51	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	44	SLC4A4
3.012e-02	-3.50	Tgif disruption of Shh signaling	WikiPathways	WP3674	9	1	5310	18	GLI3
3.018e-02	-3.50	transporter complex	cellular component	GO:1990351	461	4	19108	49	CACHD1,ATP1A2,RYR3,GABRB1
3.021e-02	-3.50	response to organic substance	biological process	GO:0010033	2498	12	18204	49	NTRK2,RYR3,SORBS1,ATP1A2,SLC1A2,AQP4,RORA,GNA14,GABRB1,SLC1A3,ADCY2,TNIK
3.026e-02	-3.50	Pathways in cancer	KEGG pathways	hsa05200	395	4	7161	22	FGFR3,ADCY2,CTNNA2,GLI3
3.027e-02	-3.50	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	49	SORBS1,RORA
3.027e-02	-3.50	regulation of synapse structure or activity	biological process	GO:0050803	252	3	18204	49	GPM6A,NTRK2,CTNNA2
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.036e-02	-3.49	NRAS (NRAS proto-oncogene, GTPase)	protein interactions	4893	683	5	19454	50	MACF1,CACHD1,TNIK,SLC1A3,FMN2
3.039e-02	-3.49	skin-hand-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-hand-carcinoma-squamous_cell_carcinoma	407	4	16828	49	HIF3A,SLC4A4,FGFR3,SHROOM3
3.042e-02	-3.49	SSTR2 (somatostatin receptor 2)	protein interactions	6752	12	1	19454	50	GNA14
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	LGR5 (leucine rich repeat containing G protein-coupled receptor 5)	protein interactions	8549	12	1	19454	50	ZNRF3
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	PROK2 (prokineticin 2)	protein interactions	60675	12	1	19454	50	CPE
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.067e-02	-3.48	PROKAR_LIPOPROTEIN	prosite domains	PS51257	76	2	12186	44	CPE,GLIS3
3.082e-02	-3.48	alpha-beta T cell activation	biological process	GO:0046631	102	2	18204	49	GLI3,RORA
3.083e-02	-3.48	response to stimulus	biological process	GO:0050896	7803	28	18204	49	SOX5,GABRB1,GLI3,RORA,FMN2,SPARCL1,FGFR3,SLC1A3,CTNND2,PREX2,BMPR1B,CTNNA2,ZNRF3,SORBS1,CPE,GNA14,AQP4,ADCY2,TNIK,MACF1,DTNA,SHROOM3,GPM6A,NTRK2,PITPNC1,SLC1A2,RYR3,ATP1A2
3.100e-02	-3.47	RHOA (ras homolog family member A)	protein interactions	387	1186	7	19454	50	FMN2,CTNNA2,PARD3B,PREX2,STON2,GLUD1,MACF1
3.101e-02	-3.47	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	49	TNIK,MACF1,CTNNA2,NTRK2
3.125e-02	-3.47	regulation of biological process	biological process	GO:0050789	12079	39	18204	49	CTNND2,GPC5,RANBP3L,PREX2,CTNNA2,BMPR1B,MSI2,NKAIN3,NPAS3,SORBS1,ZNRF3,GLI3,GABRB1,SOX5,FMN2,RORA,GLUD1,SPARCL1,FGFR3,SLC1A3,MACF1,DTNA,SHROOM3,STON2,HIF3A,GPM6A,SLC4A4,GLIS3,PITPNC1,NTRK2,SLC1A2,ATP1A2,RYR3,CPE,GNA14,RFX4,TNIK,ADCY2,SFXN5
3.129e-02	-3.46	Morphine addiction	KEGG pathways	ko05032	91	2	7161	22	GABRB1,ADCY2
3.129e-02	-3.46	Morphine addiction	KEGG pathways	hsa05032	91	2	7161	22	GABRB1,ADCY2
3.131e-02	-3.46	biological regulation	biological process	GO:0065007	12501	40	18204	49	SPARCL1,SLC1A3,FGFR3,GLUD1,RORA,FMN2,SOX5,GLI3,GABRB1,BMPR1B,CTNNA2,PREX2,ZNRF3,SORBS1,NPAS3,MSI2,NKAIN3,RANBP3L,CTNND2,GPC5,RFX4,ADCY2,SFXN5,TNIK,CPE,AQP4,GNA14,NTRK2,GLIS3,PITPNC1,SLC4A4,GPM6A,HIF3A,RYR3,ATP1A2,SLC1A2,SHROOM3,DTNA,MACF1,STON2
3.138e-02	-3.46	G protein-coupled neurotransmitter receptor activity	molecular function	GO:0099528	12	1	18094	48	GABRB1
3.138e-02	-3.46	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	48	ADCY2
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	RYR3,MSI2
3.149e-02	-3.46	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	50	FMN2,NHSL1,ABLIM1,MACF1
3.151e-02	-3.46	protein complex oligomerization	biological process	GO:0051259	256	3	18204	49	AQP4,RYR3,SLC1A2
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.158e-02	-3.46	congenital	COSMIC cancer mutations	congenital	11	1	16828	49	FGFR3
3.158e-02	-3.46	oncocytoma	COSMIC cancer mutations	oncocytoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	prostate-hyperplasia	COSMIC cancer mutations	prostate-hyperplasia	11	1	16828	49	FGFR3
3.158e-02	-3.46	seborrhoeic_keratosis	COSMIC cancer mutations	seborrhoeic_keratosis	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	skin-neck-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-neck-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	skin-scalp-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-basal_cell_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	pleomorphic_carcinoma	COSMIC cancer mutations	pleomorphic_carcinoma	11	1	16828	49	FGFR3
3.158e-02	-3.46	kidney-other-oncocytoma	COSMIC cancer mutations	kidney-other-oncocytoma	11	1	16828	49	FGFR3
3.184e-02	-3.45	pigment accumulation	biological process	GO:0043476	12	1	18204	49	SHROOM3
3.184e-02	-3.45	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	49	SLC1A2
3.184e-02	-3.45	auditory behavior	biological process	GO:0031223	12	1	18204	49	SLC1A3
3.184e-02	-3.45	negative thymic T cell selection	biological process	GO:0045060	12	1	18204	49	GLI3
3.184e-02	-3.45	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	49	BMPR1B
3.184e-02	-3.45	cellular pigment accumulation	biological process	GO:0043482	12	1	18204	49	SHROOM3
3.184e-02	-3.45	dicarboxylic acid biosynthetic process	biological process	GO:0043650	12	1	18204	49	GLUD1
3.184e-02	-3.45	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	49	BMPR1B
3.193e-02	-3.44	AP2_Mu_C_sf	interpro domains	IPR036168	12	1	18521	50	STON2
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.197e-02	-3.44	FOLN	smart domains	SM00274	9	1	9717	35	SPARCL1
3.200e-02	-3.44	CLSTN1 (calsyntenin 1)	protein interactions	22883	109	2	19454	50	SLC1A3,MGAT4C
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.204e-02	-3.44	RFX_DBD	prosite domains	PS51526	9	1	12186	44	RFX4
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	GPC5,SLC4A4,CACHD1,MACF1,SOX5,NTM,ZNRF3,SPARCL1,PREX2,SLC1A2,RORA,DTNA,GLI3,GABRB1,RFX4,STON2,CTNND2,SORBS1,CPE,NTRK2,ABLIM1,FGFR3,HIF3A,NHSL1,MGAT4C,LSAMP,SFXN5,FBXL7,GLUD1,TNIK,MSI2,NPAS3,ATP1A2,BMPR1B,RANBP3L,PAMR1,SLC1A3,GPM6A,ATP13A4,RYR3,GLIS3,FMN2,GNA14,PARD3B,SHROOM3,ADCY2,AQP4,PITPNC1
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	ATP13A4,RYR3,GLIS3,FMN2,GNA14,PARD3B,SHROOM3,ADCY2,AQP4,PITPNC1,NPAS3,ATP1A2,BMPR1B,RANBP3L,PAMR1,SLC1A3,GPM6A,STON2,CTNND2,SORBS1,CPE,NTRK2,ABLIM1,FGFR3,HIF3A,NHSL1,MGAT4C,LSAMP,SFXN5,FBXL7,GLUD1,TNIK,MSI2,GPC5,SLC4A4,CACHD1,SOX5,MACF1,NTM,ZNRF3,SPARCL1,PREX2,SLC1A2,RORA,GLI3,DTNA,GABRB1,RFX4
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	5	ADCY2
3.249e-02	-3.43	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	5	ADCY2
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	5	ADCY2
3.249e-02	-3.43	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	5	ADCY2
3.249e-02	-3.43	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	5	ADCY2
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	PARD3B,BMPR1B
3.256e-02	-3.42	CarboxypepD_reg	pfam domains	PF13620	12	1	17795	49	CPE
3.271e-02	-3.42	RDX (radixin)	protein interactions	5962	272	3	19454	50	FGFR3,MACF1,ABLIM1
3.275e-02	-3.42	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	49	TNIK,GPM6A,MACF1,NTRK2,CTNNA2
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	ATP1A2,RORA
3.291e-02	-3.41	PLPPR4 (phospholipid phosphatase related 4)	protein interactions	9890	13	1	19454	50	ZNRF3
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	Pias1 (protein inhibitor of activated STAT 1)	protein interactions	56469	13	1	19454	50	GLI3
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.296e-02	-3.41	Carboxypeptidase-like, regulatory domain	gene3d domains	2.60.40.1120	11	1	14470	44	CPE
3.307e-02	-3.41	oogenesis	biological process	GO:0048477	106	2	18204	49	FMN2,BMPR1B
3.307e-02	-3.41	pigmentation	biological process	GO:0043473	106	2	18204	49	SHROOM3,GLI3
3.310e-02	-3.41	bladder	COSMIC cancer mutations	bladder	14112	46	16828	49	ATP13A4,RYR3,GLIS3,FMN2,GNA14,PARD3B,SHROOM3,ADCY2,PITPNC1,NPAS3,ATP1A2,BMPR1B,RANBP3L,SLC1A3,PAMR1,GPM6A,STON2,SORBS1,CTNND2,NTRK2,CPE,ABLIM1,FGFR3,HIF3A,MGAT4C,LSAMP,FBXL7,GLUD1,SFXN5,MSI2,TNIK,GPC5,SLC4A4,CACHD1,MACF1,SOX5,NTM,ZNRF3,SPARCL1,PREX2,SLC1A2,DTNA,GLI3,RORA,GABRB1,RFX4
3.310e-02	-3.41	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	46	16828	49	NPAS3,RANBP3L,ATP1A2,BMPR1B,SLC1A3,PAMR1,GPM6A,RYR3,ATP13A4,GNA14,PARD3B,SHROOM3,GLIS3,FMN2,ADCY2,PITPNC1,GPC5,SLC4A4,NTM,CACHD1,SOX5,MACF1,SLC1A2,ZNRF3,SPARCL1,PREX2,GABRB1,RFX4,DTNA,GLI3,RORA,SORBS1,CTNND2,STON2,ABLIM1,FGFR3,NTRK2,CPE,LSAMP,HIF3A,MGAT4C,MSI2,TNIK,FBXL7,GLUD1,SFXN5
3.330e-02	-3.40	Hedgehog signaling	KEGG pathways	hsa_M00678	11	1	7161	22	GLI3
3.330e-02	-3.40	Hedgehog signaling	KEGG pathways	M00678	11	1	7161	22	GLI3
3.342e-02	-3.40	TyrKc	smart domains	SM00219	80	2	9717	35	NTRK2,FGFR3
3.379e-02	-3.39	positive regulation of cell differentiation	biological process	GO:0045597	906	6	18204	49	SOX5,GLI3,RANBP3L,MACF1,BMPR1B,NTRK2
3.387e-02	-3.39	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	8	16828	49	SLC4A4,NPAS3,SORBS1,ATP1A2,MACF1,NTM,PARD3B,SHROOM3
3.389e-02	-3.38	human chr4p12	chromosome location	human chr4p12	18	1	26134	50	GABRB1
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.395e-02	-3.38	GABA-gated chloride ion channel activity	molecular function	GO:0022851	13	1	18094	48	GABRB1
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.418e-02	-3.38	GFI1B (growth factor independent 1B transcriptional repressor)	protein interactions	8328	113	2	19454	50	ZNRF3,DTNA
3.427e-02	-3.37	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	13	16828	49	RFX4,GLI3,SLC1A2,NHSL1,ADCY2,ZNRF3,FGFR3,FMN2,SOX5,CACHD1,ATP1A2,NTRK2,CTNND2
3.440e-02	-3.37	cervix-carcinoma-mixed_adenosquamous_carcinoma	COSMIC cancer mutations	cervix-carcinoma-mixed_adenosquamous_carcinoma	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-benign_melanocytic_nevus	COSMIC cancer mutations	skin-benign_melanocytic_nevus	12	1	16828	49	FGFR3
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.440e-02	-3.37	skin-face-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-basal_cell_carcinoma	12	1	16828	49	FGFR3
3.444e-02	-3.37	negative T cell selection	biological process	GO:0043383	13	1	18204	49	GLI3
3.444e-02	-3.37	ventral spinal cord interneuron differentiation	biological process	GO:0021514	13	1	18204	49	GLI3
3.444e-02	-3.37	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	49	ATP1A2
3.444e-02	-3.37	prepulse inhibition	biological process	GO:0060134	13	1	18204	49	CTNNA2
3.444e-02	-3.37	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	49	RORA
3.444e-02	-3.37	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	49	RORA
3.444e-02	-3.37	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	49	ATP1A2
3.446e-02	-3.37	FGFR3 mutant receptor activation	REACTOME pathways	R-HSA-2033514	12	1	10285	30	FGFR3
3.446e-02	-3.37	Regulation of gene expression by Hypoxia-inducible Factor	REACTOME pathways	R-HSA-1234158	12	1	10285	30	HIF3A
3.446e-02	-3.37	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	30	GPC5
3.446e-02	-3.37	Signaling by activated point mutants of FGFR3	REACTOME pathways	R-HSA-1839130	12	1	10285	30	FGFR3
3.446e-02	-3.37	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	30	GPC5
3.452e-02	-3.37	Circadian entrainment	KEGG pathways	hsa04713	96	2	7161	22	RYR3,ADCY2
3.452e-02	-3.37	Circadian entrainment	KEGG pathways	ko04713	96	2	7161	22	ADCY2,RYR3
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	SORBS1,ATP1A2
3.475e-02	-3.36	Hedgehog 'off' state	REACTOME pathways	R-HSA-5610787	101	2	10285	30	ADCY2,GLI3
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	BMPR1B,SOX5
3.539e-02	-3.34	chloride transmembrane transport	biological process	GO:1902476	110	2	18204	49	GABRB1,SLC1A3
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	FGF7 (fibroblast growth factor 7)	protein interactions	2252	14	1	19454	50	FGFR3
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	PLXNA4 (plexin A4)	protein interactions	91584	14	1	19454	50	GPM6A
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.540e-02	-3.34	RSPO1 (R-spondin 1)	protein interactions	284654	14	1	19454	50	ZNRF3
3.545e-02	-3.34	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	3	16828	49	ADCY2,GPC5,NPAS3
3.545e-02	-3.34	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	3	16828	49	NPAS3,GPC5,ADCY2
3.546e-02	-3.34	MIR	smart domains	SM00472	10	1	9717	35	RYR3
3.554e-02	-3.34	MIP	prosite domains	PS00221	10	1	12186	44	AQP4
3.554e-02	-3.34	MIR	prosite domains	PS50919	10	1	12186	44	RYR3
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr10q23.2	chromosome location	human chr10q23.2	19	1	26134	50	GLUD1
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.586e-02	-3.33	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	2	19454	50	MACF1,SPARCL1
3.590e-02	-3.33	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	44	CTNNA2
3.590e-02	-3.33	Mu homology domain, subdomain B	gene3d domains	2.60.40.1170	12	1	14470	44	STON2
3.593e-02	-3.33	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	49	TNIK,CTNNA2,NTRK2,MACF1,GPM6A
3.605e-02	-3.32	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	5	ADCY2
3.612e-02	-3.32	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	49	TNIK,FGFR3,NTRK2,BMPR1B
3.612e-02	-3.32	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	49	TNIK,FGFR3,NTRK2,BMPR1B
3.612e-02	-3.32	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	25	16828	49	ZNRF3,PAMR1,PREX2,RORA,GLI3,GPC5,NPAS3,RANBP3L,CACHD1,SOX5,MACF1,ADCY2,AQP4,MGAT4C,GLUD1,RYR3,CTNND2,SORBS1,STON2,ATP13A4,SHROOM3,PARD3B,CPE,NTRK2,FMN2
3.619e-02	-3.32	cell migration	biological process	GO:0016477	921	6	18204	49	CTNNA2,NTRK2,GPM6A,FMN2,GPC5,GLI3
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.678e-02	-3.30	HLH_DNA-bd_sf	interpro domains	IPR036638	112	2	18521	50	HIF3A,NPAS3
3.678e-02	-3.30	bHLH_dom	interpro domains	IPR011598	112	2	18521	50	NPAS3,HIF3A
3.704e-02	-3.30	cell surface receptor signaling pathway	biological process	GO:0007166	1992	10	18204	49	MACF1,CPE,GLI3,CTNND2,NTRK2,BMPR1B,TNIK,FGFR3,SORBS1,ZNRF3
3.704e-02	-3.30	cellular response to forskolin	biological process	GO:1904322	14	1	18204	49	ADCY2
3.704e-02	-3.30	mechanosensory behavior	biological process	GO:0007638	14	1	18204	49	SLC1A3
3.704e-02	-3.30	response to forskolin	biological process	GO:1904321	14	1	18204	49	ADCY2
3.704e-02	-3.30	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	49	ATP1A2
3.704e-02	-3.30	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	49	SLC1A2
3.704e-02	-3.30	cerebrospinal fluid circulation	biological process	GO:0090660	14	1	18204	49	AQP4
3.704e-02	-3.30	radial glial cell differentiation	biological process	GO:0060019	14	1	18204	49	GLI3
3.704e-02	-3.30	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	49	ATP1A2
3.704e-02	-3.30	layer formation in cerebral cortex	biological process	GO:0021819	14	1	18204	49	GLI3
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	RYR3
3.715e-02	-3.29	Aquaporin-like	interpro domains	IPR023271	14	1	18521	50	AQP4
3.715e-02	-3.29	MIP	interpro domains	IPR000425	14	1	18521	50	AQP4
3.715e-02	-3.29	MHD	interpro domains	IPR028565	14	1	18521	50	STON2
3.721e-02	-3.29	skin-back-carcinoma-basal_cell_carcinoma	COSMIC cancer mutations	skin-back-carcinoma-basal_cell_carcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	cervix-carcinoma-adenocarcinoma	COSMIC cancer mutations	cervix-carcinoma-adenocarcinoma	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-virilizing_syndrome_producing	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_adenoma-virilizing_syndrome_producing	13	1	16828	49	CACHD1
3.721e-02	-3.29	endometrium-ovary-endometriosis	COSMIC cancer mutations	endometrium-ovary-endometriosis	13	1	16828	49	FGFR3
3.721e-02	-3.29	Brenner_tumour	COSMIC cancer mutations	Brenner_tumour	13	1	16828	49	FGFR3
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.728e-02	-3.29	FGFR3c ligand binding and activation	REACTOME pathways	R-HSA-190372	13	1	10285	30	FGFR3
3.728e-02	-3.29	GABA A receptor activation	REACTOME pathways	R-HSA-977441	13	1	10285	30	GABRB1
3.728e-02	-3.29	Passive transport by Aquaporins	REACTOME pathways	R-HSA-432047	13	1	10285	30	AQP4
3.728e-02	-3.29	FGFR3 ligand binding and activation	REACTOME pathways	R-HSA-190239	13	1	10285	30	FGFR3
3.728e-02	-3.29	Phospholipase C-mediated cascade; FGFR3	REACTOME pathways	R-HSA-5654227	13	1	10285	30	FGFR3
3.754e-02	-3.28	basal plasma membrane	cellular component	GO:0009925	288	3	19108	49	SLC1A3,SLC4A4,AQP4
3.768e-02	-3.28	ATP binding	molecular function	GO:0005524	1467	8	18094	48	GLUD1,TNIK,ADCY2,ATP1A2,BMPR1B,NTRK2,FGFR3,ATP13A4
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	50	TNIK
3.788e-02	-3.27	PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	27344	15	1	19454	50	MGAT4C
3.788e-02	-3.27	FGF9 (fibroblast growth factor 9)	protein interactions	2254	15	1	19454	50	FGFR3
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	RNASE13 (ribonuclease A family member 13 (inactive))	protein interactions	440163	15	1	19454	50	CPE
3.788e-02	-3.27	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	2	7161	22	GABRB1,ADCY2
3.788e-02	-3.27	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	2	7161	22	ADCY2,GABRB1
3.788e-02	-3.27	MIP	pfam domains	PF00230	14	1	17795	49	AQP4
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	SORBS1,GLUD1,ABLIM1
3.814e-02	-3.27	LRP6 (LDL receptor related protein 6)	protein interactions	4040	120	2	19454	50	ZNRF3,MGAT4C
3.822e-02	-3.26	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	16	16828	49	TNIK,GPM6A,PREX2,PAMR1,NHSL1,ADCY2,SPARCL1,ABLIM1,MACF1,SOX5,FMN2,ATP1A2,CTNND2,RYR3,SLC4A4,GPC5
3.840e-02	-3.26	middle_third	COSMIC cancer mutations	middle_third	3533	16	16828	49	GPM6A,TNIK,SPARCL1,ADCY2,PREX2,PAMR1,NHSL1,ATP1A2,MACF1,SOX5,FMN2,ABLIM1,GPC5,SLC4A4,RYR3,CTNND2
3.840e-02	-3.26	KIF14 (kinesin family member 14)	protein interactions	9928	1803	9	19454	50	SOX5,STON2,GLUD1,ABLIM1,MACF1,MSI2,SLC1A3,SHROOM3,SORBS1
3.851e-02	-3.26	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	49	NTRK2,BMPR1B,TNIK,FGFR3
3.878e-02	-3.25	actin filament organization	biological process	GO:0007015	278	3	18204	49	SHROOM3,FMN2,SORBS1
3.881e-02	-3.25	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	2	16828	49	HIF3A,PARD3B
3.894e-02	-3.25	RanBD	smart domains	SM00160	11	1	9717	35	RANBP3L
3.900e-02	-3.24	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	6	16828	49	BMPR1B,MACF1,NTRK2,TNIK,FGFR3,PREX2
3.902e-02	-3.24	RANBD1	prosite domains	PS50196	11	1	12186	44	RANBP3L
3.902e-02	-3.24	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	44	NTRK2
3.908e-02	-3.24	neurexin family protein binding	molecular function	GO:0042043	15	1	18094	48	CPE
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.914e-02	-3.24	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	49	SLC4A4,ATP13A4,FMN2
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	DTNA,NHSL1
3.943e-02	-3.23	human chr4q32.3	chromosome location	human chr4q32.3	21	1	26134	50	CPE
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.947e-02	-3.23	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	5	16828	49	PREX2,BMPR1B,NTRK2,TNIK,FGFR3
3.949e-02	-3.23	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	21	SLC4A4
3.959e-02	-3.23	Ammonia Recycling	SMPDB pathways	SMP0000009	11	1	1369	5	GLUD1
3.959e-02	-3.23	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	5	RORA
3.964e-02	-3.23	system process	biological process	GO:0003008	2015	10	18204	49	SLC1A2,SLC1A3,RYR3,ATP1A2,ABLIM1,NTRK2,SLC4A4,CTNNA2,AQP4,DTNA
3.964e-02	-3.23	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	49	SORBS1
3.964e-02	-3.23	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	49	RYR3
3.964e-02	-3.23	chondrocyte proliferation	biological process	GO:0035988	15	1	18204	49	FGFR3
3.964e-02	-3.23	response to caffeine	biological process	GO:0031000	15	1	18204	49	RYR3
3.964e-02	-3.23	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	49	MACF1
3.964e-02	-3.23	protein homotrimerization	biological process	GO:0070207	15	1	18204	49	SLC1A2
3.964e-02	-3.23	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	49	ATP1A2
3.964e-02	-3.23	dorsal/ventral neural tube patterning	biological process	GO:0021904	15	1	18204	49	GLI3
3.964e-02	-3.23	apical protein localization	biological process	GO:0045176	15	1	18204	49	SHROOM3
3.964e-02	-3.23	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	49	NTRK2
3.964e-02	-3.23	neuroblast division	biological process	GO:0055057	15	1	18204	49	SOX5
3.964e-02	-3.23	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	49	NTRK2
3.964e-02	-3.23	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	49	ATP1A2
3.964e-02	-3.23	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	49	RORA
3.970e-02	-3.23	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	5	16828	49	ABLIM1,FGFR3,TNIK,MACF1,PREX2
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.997e-02	-3.22	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	18	BMPR1B
3.997e-02	-3.22	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	18	RYR3
4.002e-02	-3.22	endometriosis	COSMIC cancer mutations	endometriosis	14	1	16828	49	FGFR3
4.002e-02	-3.22	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-renal_pelvis-carcinoma-transitional_cell_carcinoma	14	1	16828	49	FGFR3
4.002e-02	-3.22	in_situ_neoplasm	COSMIC cancer mutations	in_situ_neoplasm	14	1	16828	49	FGFR3
4.002e-02	-3.22	small_round_cell_tumour	COSMIC cancer mutations	small_round_cell_tumour	14	1	16828	49	FGFR3
4.002e-02	-3.22	soft_tissue-small_round_cell_tumour	COSMIC cancer mutations	soft_tissue-small_round_cell_tumour	14	1	16828	49	FGFR3
4.010e-02	-3.22	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	30	ABLIM1
4.023e-02	-3.21	Prot_kinase_dom	interpro domains	IPR000719	480	4	18521	50	FGFR3,TNIK,BMPR1B,NTRK2
4.024e-02	-3.21	G Protein Signaling Pathways	WikiPathways	WP35	95	2	5310	18	ADCY2,GNA14
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	CTSK (cathepsin K)	protein interactions	1513	16	1	19454	50	FGFR3
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	FZD4 (frizzled class receptor 4)	protein interactions	8322	16	1	19454	50	ZNRF3
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	HLA-H (major histocompatibility complex, class I, H (pseudogene))	protein interactions	3136	16	1	19454	50	FGFR3
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	FMN2
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.092e-02	-3.20	regulation of signaling	biological process	GO:0023051	3534	15	18204	49	CTNND2,GPC5,MACF1,ATP1A2,ZNRF3,SORBS1,BMPR1B,NTRK2,PREX2,RORA,GLUD1,GLI3,SLC1A3,TNIK,FGFR3
4.101e-02	-3.19	Ig-like_dom_sf	interpro domains	IPR036179	483	4	18521	50	FGFR3,NTRK2,LSAMP,NTM
4.106e-02	-3.19	SLAMF1 (signaling lymphocytic activation molecule family member 1)	protein interactions	6504	125	2	19454	50	CACHD1,CPE
4.106e-02	-3.19	SCGB1D1 (secretoglobin family 1D member 1)	protein interactions	10648	125	2	19454	50	CPE,CACHD1
4.112e-02	-3.19	export from cell	biological process	GO:0140352	485	4	18204	49	ATP1A2,NTRK2,CPE,SLC4A4
4.117e-02	-3.19	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	48	SLC1A3,SLC4A4,SLC1A2
4.126e-02	-3.19	Integration of energy metabolism	REACTOME pathways	R-HSA-163685	111	2	10285	30	GNA14,ADCY2
4.127e-02	-3.19	human chr3q13.31	chromosome location	human chr3q13.31	22	1	26134	50	LSAMP
4.156e-02	-3.18	regulation of cell communication	biological process	GO:0010646	3541	15	18204	49	RORA,GLUD1,GLI3,SLC1A3,TNIK,FGFR3,MACF1,GPC5,CTNND2,BMPR1B,NTRK2,PREX2,ATP1A2,ZNRF3,SORBS1
4.163e-02	-3.18	water channel activity	molecular function	GO:0015250	16	1	18094	48	AQP4
4.163e-02	-3.18	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	48	ADCY2
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.163e-02	-3.18	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	GO:0099507	16	1	18094	48	GABRB1
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.176e-02	-3.18	Glycerol uptake facilitator protein	gene3d domains	1.20.1080.10	14	1	14470	44	AQP4
4.198e-02	-3.17	ossification	biological process	GO:0001503	287	3	18204	49	GLI3,FGFR3,BMPR1B
4.207e-02	-3.17	chloride transport	biological process	GO:0006821	121	2	18204	49	SLC1A3,GABRB1
4.223e-02	-3.16	cardiac left ventricle morphogenesis	biological process	GO:0003214	16	1	18204	49	CPE
4.223e-02	-3.16	asymmetric cell division	biological process	GO:0008356	16	1	18204	49	SOX5
4.223e-02	-3.16	glutamine family amino acid biosynthetic process	biological process	GO:0009084	16	1	18204	49	GLUD1
4.223e-02	-3.16	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	49	ATP1A2
4.223e-02	-3.16	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	49	ATP1A2
4.223e-02	-3.16	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	49	ATP1A2
4.223e-02	-3.16	tricarboxylic acid metabolic process	biological process	GO:0072350	16	1	18204	49	GLUD1
4.223e-02	-3.16	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	49	SLC1A3
4.223e-02	-3.16	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	49	SLC1A2
4.223e-02	-3.16	spinal cord dorsal/ventral patterning	biological process	GO:0021513	16	1	18204	49	GLI3
4.223e-02	-3.16	regulation of Wnt signaling pathway, planar cell polarity pathway	biological process	GO:2000095	16	1	18204	49	ZNRF3
4.223e-02	-3.16	nose development	biological process	GO:0043584	16	1	18204	49	GLI3
4.223e-02	-3.16	insulin metabolic process	biological process	GO:1901142	16	1	18204	49	CPE
4.223e-02	-3.16	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	49	ATP1A2
4.223e-02	-3.16	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	3	16828	49	RYR3,SOX5,GLI3
4.225e-02	-3.16	EF_HAND_2	prosite domains	PS50222	215	3	12186	44	RYR3,MACF1,SPARCL1
4.235e-02	-3.16	GproteinA_insert	interpro domains	IPR011025	16	1	18521	50	GNA14
4.235e-02	-3.16	CarboxyPept-like_regulatory	interpro domains	IPR008969	16	1	18521	50	CPE
4.235e-02	-3.16	Gprotein_alpha_su	interpro domains	IPR001019	16	1	18521	50	GNA14
4.267e-02	-3.15	neuron projection terminus	cellular component	GO:0044306	128	2	19108	49	SLC1A2,NTRK2
4.282e-02	-3.15	ureter	COSMIC cancer mutations	ureter	15	1	16828	49	FGFR3
4.282e-02	-3.15	CCDC32 (coiled-coil domain containing 32)	protein interactions	90416	17	1	19454	50	STON2
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.283e-02	-3.15	central_nervous_system-brainstem-glioma-astrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_III	113	2	16828	49	ADCY2,STON2
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	SOX5,MACF1
4.290e-02	-3.15	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	30	ADCY2
4.290e-02	-3.15	N-Glycan antennae elongation	REACTOME pathways	R-HSA-975577	15	1	10285	30	MGAT4C
4.290e-02	-3.15	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	30	ADCY2
4.297e-02	-3.15	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	6	19454	50	DTNA,MACF1,FMN2,PREX2,STON2,SLC1A3
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.313e-02	-3.14	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	5	ATP1A2
4.313e-02	-3.14	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	5	ATP1A2
4.318e-02	-3.14	G-alpha	pfam domains	PF00503	16	1	17795	49	GNA14
4.323e-02	-3.14	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	1	5310	18	RYR3
4.329e-02	-3.14	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	49	BMPR1B,NTRK2,TNIK,FGFR3
4.334e-02	-3.14	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	5	16828	49	BMPR1B,NTRK2,SPARCL1,TNIK,FGFR3
4.346e-02	-3.14	POLA2 (DNA polymerase alpha 2, accessory subunit)	protein interactions	23649	129	2	19454	50	FGFR3,CPE
4.346e-02	-3.14	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	2	19454	50	STON2,ABLIM1
4.350e-02	-3.13	cellular response to growth factor stimulus	biological process	GO:0071363	494	4	18204	49	NTRK2,BMPR1B,FGFR3,SOX5
4.388e-02	-3.13	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	49	NTRK2,BMPR1B,TNIK,FGFR3
4.400e-02	-3.12	basal part of cell	cellular component	GO:0045178	307	3	19108	49	AQP4,SLC4A4,SLC1A3
4.428e-02	-3.12	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	5	16828	49	SPARCL1,NTRK2,BMPR1B,TNIK,FGFR3
4.432e-02	-3.12	endomembrane system	cellular component	GO:0012505	4764	18	19108	49	ATP13A4,RANBP3L,TNIK,SPARCL1,NTRK2,AQP4,PARD3B,ATP1A2,MGAT4C,FMN2,FGFR3,GLUD1,CPE,RYR3,STON2,GPC5,GABRB1,MACF1
4.440e-02	-3.11	protein-containing complex	cellular component	GO:0032991	6542	23	19108	49	HIF3A,GABRB1,SLC1A2,STON2,FBXL7,SOX5,SORBS1,CACHD1,RYR3,BMPR1B,NPAS3,FGFR3,NTRK2,PARD3B,CTNNA2,ATP1A2,GNA14,RFX4,RORA,GLI3,RANBP3L,SLC1A3,DTNA
4.461e-02	-3.11	cerebral cortex development	biological process	GO:0021987	125	2	18204	49	GLI3,NTRK2
4.467e-02	-3.11	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	44	FMN2
4.477e-02	-3.11	Helix-loop-helix DNA-binding domain	gene3d domains	4.10.280.10	111	2	14470	44	NPAS3,HIF3A
4.481e-02	-3.11	cell population proliferation	biological process	GO:0008283	726	5	18204	49	RORA,ZNRF3,SOX5,FGFR3,GLI3
4.481e-02	-3.11	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	49	ATP1A2
4.481e-02	-3.11	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	49	RORA
4.481e-02	-3.11	embryonic digestive tract morphogenesis	biological process	GO:0048557	17	1	18204	49	GLI3
4.481e-02	-3.11	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	49	ATP1A2
4.481e-02	-3.11	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	49	CTNNA2
4.481e-02	-3.11	specification of animal organ identity	biological process	GO:0010092	17	1	18204	49	GLI3
4.481e-02	-3.11	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	49	NTRK2
4.481e-02	-3.11	microvillus assembly	biological process	GO:0030033	17	1	18204	49	TNIK
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	RYR3
4.481e-02	-3.11	cGMP metabolic process	biological process	GO:0046068	17	1	18204	49	RORA
4.481e-02	-3.11	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	49	SORBS1
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	SLC1A2
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY2
4.493e-02	-3.10	PAC	interpro domains	IPR001610	17	1	18521	50	HIF3A
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	RANBP3L,BMPR1B,ATP1A2,NPAS3,GPM6A,PAMR1,SLC1A3,SHROOM3,PARD3B,GNA14,FMN2,GLIS3,RYR3,ATP13A4,AQP4,PITPNC1,ADCY2,NTM,NKAIN3,SOX5,MACF1,CACHD1,SLC4A4,GPC5,RFX4,GABRB1,RORA,GLI3,DTNA,SLC1A2,PREX2,ZNRF3,SPARCL1,FGFR3,ABLIM1,CPE,NTRK2,CTNND2,SORBS1,STON2,TNIK,MSI2,SFXN5,FBXL7,GLUD1,LSAMP,NHSL1,MGAT4C,HIF3A
4.517e-02	-3.10	PROTEIN_KINASE_TYR	prosite domains	PS00109	94	2	12186	44	NTRK2,FGFR3
4.519e-02	-3.10	clathrin coat of coated pit	cellular component	GO:0030132	18	1	19108	49	STON2
4.525e-02	-3.10	limbic system development	biological process	GO:0021761	126	2	18204	49	ATP1A2,GLI3
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	NECTIN1 (nectin cell adhesion molecule 1)	protein interactions	5818	18	1	19454	50	FGFR3
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.530e-02	-3.09	GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1)	protein interactions	338328	132	2	19454	50	FGFR3,CPE
4.531e-02	-3.09	positive regulation of nervous system development	biological process	GO:0051962	296	3	18204	49	GLI3,NTRK2,MACF1
4.533e-02	-3.09	purine ribonucleoside triphosphate binding	molecular function	GO:0035639	1804	9	18094	48	NTRK2,ATP13A4,FGFR3,GNA14,TNIK,GLUD1,BMPR1B,ADCY2,ATP1A2
4.557e-02	-3.09	cytoskeletal protein binding	molecular function	GO:0008092	989	6	18094	48	ABLIM1,MACF1,SORBS1,FMN2,SHROOM3,CTNNA2
4.561e-02	-3.09	renal_pelvis	COSMIC cancer mutations	renal_pelvis	16	1	16828	49	FGFR3
4.561e-02	-3.09	normal	COSMIC cancer mutations	normal	16	1	16828	49	FGFR3
4.561e-02	-3.09	flank	COSMIC cancer mutations	flank	16	1	16828	49	FGFR3
4.561e-02	-3.09	urinary_tract-carcinoma	COSMIC cancer mutations	urinary_tract-carcinoma	16	1	16828	49	FGFR3
4.565e-02	-3.09	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	49	BMPR1B,NTRK2,FGFR3,TNIK
4.569e-02	-3.09	muscle system process	biological process	GO:0003012	297	3	18204	49	RYR3,ATP1A2,DTNA
4.570e-02	-3.09	PKA activation	REACTOME pathways	R-HSA-163615	16	1	10285	30	ADCY2
4.578e-02	-3.08	Neural Crest Differentiation	WikiPathways	WP2064	102	2	5310	18	FGFR3,SOX5
4.581e-02	-3.08	ZZ	pfam domains	PF00569	17	1	17795	49	DTNA
4.590e-02	-3.08	response to amino acid	biological process	GO:0043200	127	2	18204	49	NTRK2,SLC1A2
4.596e-02	-3.08	CARBOXYPEPT_ZN_1	prosite domains	PS00132	13	1	12186	44	CPE
4.596e-02	-3.08	CARBOXYPEPT_ZN_2	prosite domains	PS00133	13	1	12186	44	CPE
4.615e-02	-3.08	cell cortex	cellular component	GO:0005938	313	3	19108	49	PARD3B,FMN2,SHROOM3
4.621e-02	-3.07	adenyl ribonucleotide binding	molecular function	GO:0032559	1528	8	18094	48	NTRK2,TNIK,GLUD1,BMPR1B,ATP13A4,ATP1A2,ADCY2,FGFR3
4.636e-02	-3.07	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	4	12186	44	NTRK2,BMPR1B,FGFR3,TNIK
4.648e-02	-3.07	ERK Pathway in Huntington's Disease	WikiPathways	WP3853	14	1	5310	18	NTRK2
4.665e-02	-3.07	Citrullinemia Type I	SMPDB pathways	SMP0000001	13	1	1369	5	GLUD1
4.665e-02	-3.07	Argininosuccinic Aciduria	SMPDB pathways	SMP0000003	13	1	1369	5	GLUD1
4.665e-02	-3.07	Urea Cycle	SMPDB pathways	SMP0000059	13	1	1369	5	GLUD1
4.665e-02	-3.07	Carbamoyl Phosphate Synthetase Deficiency	SMPDB pathways	SMP0000002	13	1	1369	5	GLUD1
4.665e-02	-3.07	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	5	ATP1A2
4.665e-02	-3.07	Argininemia	SMPDB pathways	SMP0000357	13	1	1369	5	GLUD1
4.665e-02	-3.07	Ornithine Transcarbamylase Deficiency (OTC Deficiency)	SMPDB pathways	SMP0000205	13	1	1369	5	GLUD1
4.671e-02	-3.06	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	1	18094	48	RYR3
4.671e-02	-3.06	NAD+ binding	molecular function	GO:0070403	18	1	18094	48	GLUD1
4.671e-02	-3.06	GABA receptor binding	molecular function	GO:0050811	18	1	18094	48	GABRB1
4.671e-02	-3.06	clathrin adaptor activity	molecular function	GO:0035615	18	1	18094	48	STON2
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.716e-02	-3.05	Myo1c (myosin IC)	protein interactions	17913	135	2	19454	50	STON2,ABLIM1
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	NTM,CACHD1,NKAIN3,MACF1,SOX5,GPC5,SLC4A4,GABRB1,RFX4,RORA,GLI3,DTNA,SLC1A2,ZNRF3,SPARCL1,PREX2,ABLIM1,FGFR3,CPE,NTRK2,CTNND2,SORBS1,STON2,TNIK,MSI2,SFXN5,FBXL7,GLUD1,LSAMP,HIF3A,NHSL1,MGAT4C,RANBP3L,ATP1A2,BMPR1B,NPAS3,GPM6A,PAMR1,SLC1A3,GNA14,PARD3B,SHROOM3,GLIS3,FMN2,RYR3,ATP13A4,ADCY2,AQP4,PITPNC1
4.737e-02	-3.05	circulatory system process	biological process	GO:0003013	508	4	18204	49	SLC1A2,ATP1A2,SLC1A3,SLC4A4
4.738e-02	-3.05	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	49	NTRK2
4.738e-02	-3.05	dicarboxylic acid catabolic process	biological process	GO:0043649	18	1	18204	49	GLUD1
4.738e-02	-3.05	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	49	ATP1A2
4.738e-02	-3.05	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	49	CTNND2
4.738e-02	-3.05	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	49	RORA
4.738e-02	-3.05	receptor catabolic process	biological process	GO:0032801	18	1	18204	49	ZNRF3
4.738e-02	-3.05	spinal cord patterning	biological process	GO:0021511	18	1	18204	49	GLI3
4.749e-02	-3.05	positive regulation of cell communication	biological process	GO:0010647	1792	9	18204	49	BMPR1B,NTRK2,TNIK,FGFR3,SLC1A3,SORBS1,MACF1,GPC5,GLUD1
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY2
4.752e-02	-3.05	Leu-rich_rpt_Cys-con_subtyp	interpro domains	IPR006553	18	1	18521	50	FBXL7
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY2
4.758e-02	-3.05	GI Alpha 1, domain 2-like	gene3d domains	1.10.400.10	16	1	14470	44	GNA14
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	NTRK2,CTNND2,TNIK
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.764e-02	-3.04	GABA-A receptor complex	cellular component	GO:1902711	19	1	19108	49	GABRB1
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.772e-02	-3.04	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	2	16828	49	FMN2,CTNND2
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.777e-02	-3.04	positive regulation of signaling	biological process	GO:0023056	1794	9	18204	49	GLUD1,GPC5,MACF1,SLC1A3,SORBS1,TNIK,FGFR3,NTRK2,BMPR1B
4.785e-02	-3.04	anion binding	molecular function	GO:0043168	2412	11	18094	48	ATP13A4,PITPNC1,FGFR3,NTRK2,BMPR1B,SLC1A3,ATP1A2,ADCY2,GNA14,TNIK,GLUD1
4.793e-02	-3.04	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	3	16828	49	PREX2,ATP1A2,TNIK
4.809e-02	-3.03	cAMP signaling	KEGG pathways	hsa_M00695	16	1	7161	22	ADCY2
4.809e-02	-3.03	cAMP signaling	KEGG pathways	M00695	16	1	7161	22	ADCY2
4.809e-02	-3.03	N-glycan biosynthesis, complex type	KEGG pathways	M00075	16	1	7161	22	MGAT4C
4.809e-02	-3.03	N-glycan biosynthesis, complex type	KEGG pathways	hsa_M00075	16	1	7161	22	MGAT4C
4.839e-02	-3.03	skin-other-verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	skin-other-verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-non_chronically_sun_exposed_site-malignant_melanoma	COSMIC cancer mutations	skin-non_chronically_sun_exposed_site-malignant_melanoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	breast-carcinoma-neuroendocrine_carcinoma	COSMIC cancer mutations	breast-carcinoma-neuroendocrine_carcinoma	17	1	16828	49	FGFR3
4.839e-02	-3.03	non_chronically_sun_exposed_site	COSMIC cancer mutations	non_chronically_sun_exposed_site	17	1	16828	49	FGFR3
4.839e-02	-3.03	verrucal_keratosis_BRAF_inhibitor_related	COSMIC cancer mutations	verrucal_keratosis_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	skin-carcinoma-squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.839e-02	-3.03	squamous_cell_carcinoma_BRAF_inhibitor_related	COSMIC cancer mutations	squamous_cell_carcinoma_BRAF_inhibitor_related	17	1	16828	49	FGFR3
4.843e-02	-3.03	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	49	FGFR3,DTNA
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY2
4.848e-02	-3.03	PKA activation in glucagon signalling	REACTOME pathways	R-HSA-164378	17	1	10285	30	ADCY2
4.848e-02	-3.03	PKA-mediated phosphorylation of CREB	REACTOME pathways	R-HSA-111931	17	1	10285	30	ADCY2
4.852e-02	-3.03	carboxylic acid transmembrane transport	biological process	GO:1905039	131	2	18204	49	SLC1A3,SLC1A2
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.918e-02	-3.01	inorganic anion transmembrane transport	biological process	GO:0098661	132	2	18204	49	GABRB1,SLC1A3
4.924e-02	-3.01	water transmembrane transporter activity	molecular function	GO:0005372	19	1	18094	48	AQP4
4.924e-02	-3.01	cargo adaptor activity	molecular function	GO:0140312	19	1	18094	48	STON2
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.924e-02	-3.01	GABA-A receptor activity	molecular function	GO:0004890	19	1	18094	48	GABRB1
4.930e-02	-3.01	CNH	smart domains	SM00036	14	1	9717	35	TNIK
4.940e-02	-3.01	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	3	19454	50	DTNA,SORBS1,MACF1
4.941e-02	-3.01	MHD	prosite domains	PS51072	14	1	12186	44	STON2
4.966e-02	-3.00	cell division	biological process	GO:0051301	516	4	18204	49	PARD3B,SOX5,FBXL7,FMN2
4.968e-02	-3.00	SPCS2 (signal peptidase complex subunit 2)	protein interactions	9789	139	2	19454	50	MGAT4C,GPC5
4.968e-02	-3.00	DUSP22 (dual specificity phosphatase 22)	protein interactions	56940	139	2	19454	50	GNA14,CTNNA2
4.985e-02	-3.00	regulation of sequestering of calcium ion	biological process	GO:0051282	133	2	18204	49	ATP1A2,RYR3
4.995e-02	-3.00	cerebellar Purkinje cell layer morphogenesis	biological process	GO:0021692	19	1	18204	49	RORA
4.995e-02	-3.00	response to potassium ion	biological process	GO:0035864	19	1	18204	49	ATP1A2
4.995e-02	-3.00	microvillus organization	biological process	GO:0032528	19	1	18204	49	TNIK
4.995e-02	-3.00	vocalization behavior	biological process	GO:0071625	19	1	18204	49	GLI3
4.995e-02	-3.00	craniofacial suture morphogenesis	biological process	GO:0097094	19	1	18204	49	GLI3
4.995e-02	-3.00	regulation of neurotransmitter uptake	biological process	GO:0051580	19	1	18204	49	ATP1A2