Gene Ontology Enrichment Results

Homer de novo Motif Enrichment Results
Known Motif Enrichment Results

Text file version of complete results (i.e. open with Excel)

biological process: Functional groupings of proteins (Gene Ontology)

molecular function: Mechanistic actions of proteins (Gene Ontology)

cellular component: Protein localization (Gene Ontology)

chromosome location: Genes with similar chromosome localization (NCBI Gene)

KEGG pathways: Groups of proteins in the same pathways (KEGG)

protein interactions: "Proteins interacting with a common protein (BIND, EcoCyc, HPRD)" (NCBI Gene)

interpro domains: Proteins with similar domains and features (Interpro)

pfam domains: Proteins with similar domains and features (Pfam)

smart domains: Proteins with similar domains and features (SMART)

gene3d domains: Proteins with similar domains and features (Gene3D)

prosite domains: Proteins with similar domains and features (Prosite)

prints domains: Proteins with similar domains and features (PRINTS)

MSigDB lists: "Genes sets for pathways, factor/miRNA target predictions, expression patterns, etc." (MSigDB)

BIOCYC pathways: Groups of proteins in the same pathways (BIOCYC)

COSMIC cancer mutations: Genes mutated in similar cancers (COSMIC)

GWAS genes: Genes mutated in similar diseases (GWAS Catalog)

Lipid Maps pathways: Groups of proteins in the same lipid pathways (Lipid Maps/Biosystems)

Pathway Interaction DB: Groups of proteins in the same pathways (Pathway Interaction Database)

REACTOME pathways: Groups of proteins in the same pathways (REACTOME)

SMPDB pathways: Groups of proteins in the same pathways (SMPDB)

WikiPathways: Groups of proteins in the same pathways (Wikipathways)

Enriched Categories

P-value	ln(P)	Term	GO Tree	GO ID	# of Genes in Term	# of Target Genes in Term	# of Total Genes	# of Target Genes	Common Genes
2.337e-10	-22.18	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_B_cell_leukaemia	3828	32	16828	49	GPM6A,PREX2,NTM,MGAT4C,NKAIN3,FBXL7,SLC1A2,GPC5,LSAMP,RYR3,PAMR1,PTPRZ1,ADCY2,NTRK2,DST,SLC1A3,TNIK,SOX5,SLC4A4,NEBL,NRG3,GLIS3,ZBTB20,FMN2,BMPR1B,CTNND2,CSGALNACT1,MAML2,RORA,NFIA,GLI3,ITPR2
2.337e-10	-22.18	acute_lymphoblastic_B_cell_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_B_cell_leukaemia	3828	32	16828	49	ADCY2,NTRK2,DST,SLC1A3,TNIK,SOX5,GPM6A,PREX2,NTM,MGAT4C,NKAIN3,FBXL7,SLC1A2,GPC5,LSAMP,RYR3,PTPRZ1,PAMR1,MAML2,RORA,NFIA,GLI3,ITPR2,SLC4A4,NEBL,NRG3,ZBTB20,GLIS3,FMN2,BMPR1B,CSGALNACT1,CTNND2
5.923e-10	-21.25	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-Burkitt_lymphoma	2119	24	16828	49	NHSL1,SOX5,SLC1A3,ADCY2,NTRK2,FBXL7,SLC1A2,NKAIN3,RYR3,GPC5,LSAMP,PREX2,GPM6A,NPAS3,ITPR2,MAML2,GLI3,FMN2,CTNND2,CSGALNACT1,BMPR1B,TPD52L1,NRG3,RFX4
5.923e-10	-21.25	Burkitt_lymphoma	COSMIC cancer mutations	Burkitt_lymphoma	2119	24	16828	49	SOX5,SLC1A3,NHSL1,NTRK2,ADCY2,RYR3,GPC5,LSAMP,FBXL7,SLC1A2,NKAIN3,NPAS3,GPM6A,PREX2,ITPR2,GLI3,MAML2,CSGALNACT1,CTNND2,BMPR1B,FMN2,NRG3,TPD52L1,RFX4
6.000e-10	-21.23	prostate-carcinoma	COSMIC cancer mutations	prostate-carcinoma	9000	46	16828	49	TPD52L1,NRG3,ZBTB20,RFX4,GLIS3,SLC4A4,FMN2,CTNND2,DPP10,RORA,GLI3,SORBS1,DTNA,RYR3,GPC5,MSI2,PARD3B,ABLIM1,NEBL,MACF1,CSGALNACT1,BMPR1B,NFIA,MAML2,PRKCA,ITPR2,GPM6A,PREX2,NTM,NPAS3,TRPM3,FBXL7,SLC1A2,NKAIN3,PTPRZ1,LSAMP,ADCY2,CDH20,NTRK2,DST,PITPNC1,NHSL1,SPARCL1,TNIK,SOX5,SLC1A3
6.230e-10	-21.20	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma	7205	42	16828	49	ITPR2,GLI3,PRKCA,MAML2,RORA,NFIA,DPP10,CTNND2,CSGALNACT1,MACF1,FMN2,NEBL,SLC4A4,ZBTB20,GLIS3,RFX4,TPD52L1,NRG3,SLC1A3,ABLIM1,SOX5,TNIK,NHSL1,PITPNC1,DST,NTRK2,PARD3B,ADCY2,LSAMP,GPC5,PTPRZ1,PAMR1,RYR3,NKAIN3,SLC1A2,FBXL7,TRPM3,NPAS3,NTM,SORBS1,GPM6A,PREX2
1.166e-08	-18.27	diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	diffuse_large_B_cell_lymphoma	4151	31	16828	49	DPP10,MACF1,CTNND2,CSGALNACT1,FMN2,NEBL,TPD52L1,NRG3,ITPR2,ATP1A2,PRKCA,GLI3,RORA,MAML2,GPC5,LSAMP,RYR3,NKAIN3,FBXL7,SLC1A2,DTNA,GPM6A,PREX2,SLC1A3,TNIK,SOX5,SPARCL1,DST,NTRK2,CDH20,ADCY2
4.380e-08	-16.94	angiosarcoma	COSMIC cancer mutations	angiosarcoma	2192	22	16828	49	CTNND2,FMN2,TPD52L1,NRG3,NEBL,ITPR2,GLI3,MAML2,PTPRZ1,RYR3,LSAMP,GPC5,SLC1A2,FBXL7,NKAIN3,PREX2,GPM6A,SOX5,SLC1A3,CDH20,NTRK2,ADCY2
4.380e-08	-16.94	soft_tissue-blood_vessel-angiosarcoma	COSMIC cancer mutations	soft_tissue-blood_vessel-angiosarcoma	2192	22	16828	49	GLI3,MAML2,ITPR2,NRG3,TPD52L1,NEBL,CTNND2,FMN2,CDH20,NTRK2,ADCY2,SOX5,SLC1A3,GPM6A,PREX2,PTPRZ1,RYR3,LSAMP,GPC5,SLC1A2,FBXL7,NKAIN3
5.128e-08	-16.79	blood_vessel	COSMIC cancer mutations	blood_vessel	2211	22	16828	49	SLC1A3,SOX5,ITPR2,NTRK2,CDH20,GLI3,MAML2,ADCY2,LSAMP,GPC5,PTPRZ1,CTNND2,RYR3,NKAIN3,FMN2,SLC1A2,FBXL7,NEBL,GPM6A,PREX2,TPD52L1,NRG3
1.057e-07	-16.06	myelodysplastic_syndrome	COSMIC cancer mutations	myelodysplastic_syndrome	1174	16	16828	49	SOX5,TNIK,ATP1A2,NTRK2,PRKCA,NFIA,ADCY2,BMPR1B,LSAMP,RYR3,NKAIN3,SLC1A2,FBXL7,NPAS3,PREX2,NRG3
1.057e-07	-16.06	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-myelodysplastic_syndrome	1174	16	16828	49	LSAMP,BMPR1B,RYR3,NKAIN3,FBXL7,SLC1A2,NPAS3,NRG3,PREX2,TNIK,SOX5,ATP1A2,NTRK2,PRKCA,NFIA,ADCY2
1.132e-07	-15.99	acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	acute_myeloid_leukaemia_therapy_related	1523	18	16828	49	SLC1A3,ITPR2,SOX5,RORA,MAML2,ADCY2,NTRK2,GLI3,FMN2,NKAIN3,FBXL7,GPC5,LSAMP,RYR3,CTNND2,NEBL,PREX2,NRG3
1.132e-07	-15.99	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia_therapy_related	1523	18	16828	49	RYR3,CTNND2,GPC5,LSAMP,FBXL7,NKAIN3,FMN2,NRG3,PREX2,NEBL,ITPR2,SOX5,SLC1A3,GLI3,NTRK2,ADCY2,RORA,MAML2
1.173e-07	-15.96	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-astrocytoma_Grade_IV	2531	23	16828	49	ADCY2,CDH20,TNIK,SOX5,SLC1A3,GPM6A,PREX2,FBXL7,NKAIN3,RYR3,PTPRZ1,GPC5,LSAMP,MAML2,RORA,GLI3,PRKCA,ITPR2,TPD52L1,NRG3,ZBTB20,FMN2,CTNND2
1.451e-07	-15.75	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	27	16828	49	GLI3,PRKCA,FMN2,MACF1,CTNND2,BMPR1B,NRG3,SLC4A4,DST,PITPNC1,TNIK,SLC1A3,ADCY2,MSI2,PARD3B,NTRK2,FBXL7,RYR3,PTPRZ1,PAMR1,GPC5,LSAMP,PREX2,NPAS3,TRPM3,DTNA,MGAT4C
1.451e-07	-15.75	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	COSMIC cancer mutations	chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	3511	27	16828	49	ADCY2,MSI2,PARD3B,NTRK2,PITPNC1,DST,TNIK,SLC1A3,PREX2,TRPM3,NPAS3,MGAT4C,DTNA,FBXL7,PAMR1,PTPRZ1,RYR3,LSAMP,GPC5,PRKCA,GLI3,NRG3,SLC4A4,FMN2,CTNND2,MACF1,BMPR1B
1.593e-07	-15.65	lymphoid_neoplasm	COSMIC cancer mutations	lymphoid_neoplasm	12233	49	16828	49	ATP1A2,ITPR2,NFIA,MAML2,PRKCA,MACF1,CSGALNACT1,BMPR1B,NEBL,DST,PITPNC1,NHSL1,SPARCL1,TNIK,SOX5,SLC1A3,ADCY2,CDH20,NTRK2,FBXL7,SLC1A2,NKAIN3,PTPRZ1,LSAMP,PREX2,GPM6A,NTM,NPAS3,TRPM3,MGAT4C,RORA,GLI3,FMN2,CTNND2,DPP10,NRG3,TPD52L1,ZBTB20,RFX4,GLIS3,SLC4A4,ABLIM1,MSI2,PARD3B,RYR3,PAMR1,GPC5,SORBS1,DTNA
1.607e-07	-15.64	soft_tissue	COSMIC cancer mutations	soft_tissue	5828	35	16828	49	ADCY2,PARD3B,CDH20,NTRK2,DST,SPARCL1,NHSL1,SOX5,SLC1A3,GPM6A,SORBS1,PREX2,TRPM3,NPAS3,SLC1A2,FBXL7,NKAIN3,PTPRZ1,PAMR1,RYR3,LSAMP,GPC5,NFIA,MAML2,RORA,GLI3,ITPR2,GLIS3,NRG3,TPD52L1,NEBL,FMN2,CTNND2,MACF1,DPP10
1.813e-07	-15.52	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm	764	13	16828	49	NTRK2,MAML2,ADCY2,SOX5,ATP1A2,PREX2,NRG3,GPC5,LSAMP,RYR3,NKAIN3,FBXL7,SLC1A2
1.955e-07	-15.45	cerebellum	COSMIC cancer mutations	cerebellum	769	13	16828	49	MAML2,PARD3B,NTRK2,ABLIM1,ITPR2,NRG3,NEBL,NPAS3,PTPRZ1,CTNND2,RYR3,DPP10,GPC5
2.237e-07	-15.31	mantle_cell_lymphoma	COSMIC cancer mutations	mantle_cell_lymphoma	2849	24	16828	49	ITPR2,SOX5,SLC1A3,DST,PARD3B,PRKCA,GLI3,NTRK2,ADCY2,MAML2,RYR3,CTNND2,GPC5,LSAMP,FBXL7,SLC1A2,NKAIN3,FMN2,TRPM3,GPM6A,NRG3,PREX2,RFX4,NEBL
2.486e-07	-15.21	brainstem	COSMIC cancer mutations	brainstem	3102	25	16828	49	NPAS3,PREX2,GPM6A,RYR3,PTPRZ1,GPC5,LSAMP,FBXL7,SLC1A2,NKAIN3,CDH20,ADCY2,TNIK,SOX5,SLC1A3,NRG3,TPD52L1,ZBTB20,CTNND2,FMN2,GLI3,PRKCA,RORA,MAML2,ITPR2
2.559e-07	-15.18	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-squamous_cell_carcinoma	6953	38	16828	49	FMN2,MACF1,CTNND2,CSGALNACT1,NRG3,RFX4,ZBTB20,SLC4A4,NEBL,ATP1A2,ITPR2,MAML2,RORA,GLI3,PRKCA,FBXL7,SLC1A2,RYR3,PAMR1,PTPRZ1,GPC5,LSAMP,SORBS1,GPM6A,PREX2,NTM,TRPM3,DTNA,MGAT4C,DST,PITPNC1,NHSL1,TNIK,ABLIM1,SOX5,ADCY2,PARD3B,CDH20
2.603e-07	-15.16	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	COSMIC cancer mutations	central_nervous_system-cerebellum-primitive_neuroectodermal_tumour-medulloblastoma-SHH_subtype	653	12	16828	49	NPAS3,NEBL,NRG3,DPP10,RYR3,CTNND2,PTPRZ1,NTRK2,PARD3B,MAML2,ITPR2,ABLIM1
2.608e-07	-15.16	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	3608	27	16828	49	PRKCA,GLI3,RORA,MAML2,ITPR2,ATP1A2,TPD52L1,NRG3,NEBL,MACF1,CSGALNACT1,CTNND2,FMN2,CDH20,ADCY2,TNIK,SOX5,DST,SPARCL1,PREX2,GPM6A,RYR3,GPC5,LSAMP,FBXL7,SLC1A2,NKAIN3
2.646e-07	-15.15	SHH_subtype	COSMIC cancer mutations	SHH_subtype	654	12	16828	49	NPAS3,PARD3B,NTRK2,NRG3,NEBL,MAML2,CTNND2,PTPRZ1,ABLIM1,RYR3,ITPR2,DPP10
2.894e-07	-15.06	chondroblastoma	COSMIC cancer mutations	chondroblastoma	534	11	16828	49	GPC5,LSAMP,RYR3,CTNND2,NKAIN3,FMN2,NRG3,GPM6A,TPD52L1,SOX5,ADCY2
3.120e-07	-14.98	nervous system development	biological process	GO:0007399	2185	20	18204	49	BMPR1B,CTNNA2,ATP1A2,NTRK2,NTM,LSAMP,GLI3,SOX5,CTNND2,RORA,TNIK,NRG3,SLC1A3,NFIA,SLC1A2,PREX2,RFX4,GPM6A,MSI2,PTPRZ1
3.797e-07	-14.78	pharynx	COSMIC cancer mutations	pharynx	2696	23	16828	49	RFX4,NRG3,SLC4A4,CTNND2,MACF1,DPP10,FMN2,PRKCA,NFIA,ATP1A2,NPAS3,DTNA,SORBS1,PREX2,PTPRZ1,RYR3,GPC5,SLC1A2,PARD3B,NTRK2,PITPNC1,DST,NHSL1
5.011e-07	-14.51	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-mantle_cell_lymphoma	2737	23	16828	49	FMN2,NKAIN3,SLC1A2,FBXL7,LSAMP,GPC5,CTNND2,RYR3,NEBL,RFX4,GPM6A,NRG3,PREX2,DST,SLC1A3,SOX5,ITPR2,MAML2,ADCY2,NTRK2,PARD3B,PRKCA,GLI3
5.280e-07	-14.45	PRNP (prion protein (Kanno blood group))	protein interactions	5621	1118	14	19454	50	MSI2,GPM6A,MACF1,SORBS1,MAML2,NHSL1,SLC1A3,TRPM3,ATP1A2,SLC4A4,LSAMP,ABLIM1,PTPRZ1,SPARCL1
5.321e-07	-14.45	MAPT (microtubule associated protein tau)	protein interactions	4137	948	13	19454	50	TNIK,SORBS1,GPM6A,ATP1A2,SLC1A2,SLC1A3,NEBL,PRKCA,CTNND2,ABLIM1,CTNNA2,LSAMP,NTM
6.069e-07	-14.31	lymph_node	COSMIC cancer mutations	lymph_node	1703	18	16828	49	LSAMP,DPP10,GPC5,CTNND2,RYR3,DTNA,TRPM3,NEBL,GPM6A,NRG3,SLC1A3,SOX5,TNIK,ITPR2,NTRK2,PARD3B,PRKCA,MAML2
8.806e-07	-13.94	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-larynx-carcinoma-squamous_cell_carcinoma	1946	19	16828	49	MGAT4C,NPAS3,NEBL,SLC4A4,ZBTB20,GPM6A,BMPR1B,CSGALNACT1,RYR3,MACF1,FMN2,PARD3B,GLI3,MAML2,RORA,SOX5,ITPR2,TNIK,DST
8.947e-07	-13.93	larynx	COSMIC cancer mutations	larynx	1948	19	16828	49	NPAS3,MGAT4C,ZBTB20,GPM6A,NEBL,SLC4A4,CSGALNACT1,MACF1,RYR3,BMPR1B,FMN2,GLI3,PARD3B,MAML2,RORA,SOX5,ITPR2,TNIK,DST
1.354e-06	-13.51	generation of neurons	biological process	GO:0048699	1158	14	18204	49	CTNNA2,BMPR1B,SOX5,GLI3,NTM,NTRK2,CTNND2,SLC1A3,TNIK,RORA,NFIA,PREX2,GPM6A,PTPRZ1
1.606e-06	-13.34	cell morphogenesis	biological process	GO:0000902	687	11	18204	49	GPM6A,PTPRZ1,NFIA,PREX2,CTNND2,SLC1A3,TNIK,CTNNA2,BMPR1B,CDH20,GLI3
1.623e-06	-13.33	CTNNA1 (catenin alpha 1)	protein interactions	1495	325	8	19454	50	MACF1,SORBS1,TNIK,CTNNA2,ABLIM1,DTNA,NEBL,NHSL1
2.063e-06	-13.09	anatomical structure morphogenesis	biological process	GO:0009653	2225	19	18204	49	PTPRZ1,GPM6A,NEBL,PREX2,ABLIM1,NFIA,RORA,NRG3,TNIK,SLC1A3,CTNND2,CSGALNACT1,NTRK2,GLI3,SOX5,PRKCA,BMPR1B,CDH20,CTNNA2
2.650e-06	-12.84	plasma membrane	cellular component	GO:0005886	5538	30	19108	49	DTNA,BMPR1B,SLC4A4,SLC1A3,NRG3,FMN2,DST,RYR3,GPC5,ADCY2,PARD3B,PRKCA,CTNND2,MACF1,TNIK,PTPRZ1,ITPR2,PREX2,CTNNA2,LSAMP,SORBS1,NKAIN3,ATP1A2,CDH20,TRPM3,NTRK2,GPM6A,NTM,SLC1A2,DPP10
3.759e-06	-12.49	neuron differentiation	biological process	GO:0030182	1081	13	18204	49	PREX2,NFIA,PTPRZ1,GPM6A,NTRK2,NTM,GLI3,BMPR1B,CTNNA2,RORA,TNIK,SLC1A3,CTNND2
4.655e-06	-12.28	cell periphery	cellular component	GO:0071944	6020	31	19108	49	TRPM3,NTRK2,GPM6A,SLC1A2,NTM,DPP10,ITPR2,PREX2,CTNNA2,SPARCL1,LSAMP,SORBS1,ATP1A2,NKAIN3,CDH20,ADCY2,PRKCA,PARD3B,CTNND2,MACF1,TNIK,PTPRZ1,DTNA,BMPR1B,SLC4A4,SLC1A3,NRG3,FMN2,RYR3,GPC5,DST
4.959e-06	-12.21	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm	7307	37	16828	49	PREX2,GPM6A,MGAT4C,SLC1A2,FBXL7,NKAIN3,PAMR1,PTPRZ1,RYR3,LSAMP,GPC5,ADCY2,PARD3B,CDH20,NTRK2,SPARCL1,NHSL1,ABLIM1,SOX5,TNIK,SLC1A3,GLIS3,RFX4,NRG3,TPD52L1,NEBL,FMN2,CSGALNACT1,CTNND2,MACF1,DPP10,BMPR1B,MAML2,RORA,GLI3,PRKCA,ITPR2
6.186e-06	-11.99	cervix-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	cervix-carcinoma-squamous_cell_carcinoma	11789	47	16828	49	ABLIM1,PARD3B,RYR3,PAMR1,GPC5,SORBS1,DTNA,RORA,GLI3,FMN2,CTNND2,DPP10,TPD52L1,NRG3,GLIS3,RFX4,ZBTB20,SLC4A4,DST,PITPNC1,NHSL1,SPARCL1,TNIK,SOX5,SLC1A3,ADCY2,CDH20,NTRK2,FBXL7,SLC1A2,PTPRZ1,LSAMP,PREX2,GPM6A,NTM,NPAS3,TRPM3,MGAT4C,ATP1A2,ITPR2,NFIA,MAML2,PRKCA,MACF1,CSGALNACT1,BMPR1B,NEBL
6.238e-06	-11.98	Salivary secretion	KEGG pathways	ko04970	90	5	7161	22	RYR3,PRKCA,ADCY2,ATP1A2,ITPR2
6.238e-06	-11.98	Salivary secretion	KEGG pathways	hsa04970	90	5	7161	22	RYR3,PRKCA,ADCY2,ATP1A2,ITPR2
6.276e-06	-11.98	cervix	COSMIC cancer mutations	cervix	11793	47	16828	49	PRKCA,MAML2,NFIA,ITPR2,ATP1A2,NEBL,BMPR1B,CSGALNACT1,MACF1,NTRK2,CDH20,ADCY2,SLC1A3,SOX5,TNIK,SPARCL1,NHSL1,PITPNC1,DST,MGAT4C,TRPM3,NPAS3,NTM,GPM6A,PREX2,LSAMP,PTPRZ1,SLC1A2,FBXL7,GLI3,RORA,SLC4A4,ZBTB20,GLIS3,RFX4,TPD52L1,NRG3,DPP10,CTNND2,FMN2,PARD3B,ABLIM1,DTNA,SORBS1,GPC5,PAMR1,RYR3
6.705e-06	-11.91	carcinoid-endocrine_tumour	COSMIC cancer mutations	carcinoid-endocrine_tumour	7752	38	16828	49	ATP1A2,ITPR2,RORA,MAML2,GLI3,PRKCA,FMN2,BMPR1B,DPP10,MACF1,CSGALNACT1,CTNND2,SLC4A4,NEBL,TPD52L1,NRG3,RFX4,GLIS3,NHSL1,DST,SLC1A3,TNIK,ABLIM1,SOX5,ADCY2,NTRK2,CDH20,NKAIN3,FBXL7,SLC1A2,GPC5,LSAMP,RYR3,PAMR1,PTPRZ1,GPM6A,PREX2,TRPM3
7.103e-06	-11.85	neurogenesis	biological process	GO:0022008	1334	14	18204	49	BMPR1B,CTNNA2,NTM,NTRK2,SOX5,GLI3,CTNND2,TNIK,RORA,SLC1A3,NFIA,PREX2,GPM6A,PTPRZ1
8.073e-06	-11.73	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-mantle_cell_lymphoma	476	9	16828	49	NRG3,GPM6A,MAML2,PRKCA,TRPM3,RYR3,CTNND2,GPC5,LSAMP
8.142e-06	-11.72	Pancreatic secretion	KEGG pathways	hsa04972	95	5	7161	22	ITPR2,SLC4A4,ADCY2,ATP1A2,PRKCA
8.142e-06	-11.72	Pancreatic secretion	KEGG pathways	ko04972	95	5	7161	22	ADCY2,ATP1A2,PRKCA,ITPR2,SLC4A4
8.577e-06	-11.67	oesophagus-carcinoma	COSMIC cancer mutations	oesophagus-carcinoma	4269	27	16828	49	PREX2,GPM6A,SORBS1,NTM,TRPM3,FBXL7,RYR3,PTPRZ1,ADCY2,PARD3B,CDH20,NTRK2,NHSL1,TNIK,SOX5,NRG3,ZBTB20,RFX4,SLC4A4,FMN2,MACF1,CTNND2,CSGALNACT1,DPP10,NFIA,GLI3,ITPR2
8.905e-06	-11.63	mouth	COSMIC cancer mutations	mouth	9004	41	16828	49	FBXL7,SLC1A2,RYR3,PAMR1,PTPRZ1,GPC5,LSAMP,PREX2,GPM6A,SORBS1,NTM,NPAS3,TRPM3,DTNA,MGAT4C,DST,PITPNC1,NHSL1,TNIK,ABLIM1,SOX5,SLC1A3,ADCY2,CDH20,PARD3B,NTRK2,FMN2,MACF1,CSGALNACT1,CTNND2,NRG3,RFX4,ZBTB20,SLC4A4,NEBL,ATP1A2,ITPR2,RORA,MAML2,PRKCA,GLI3
9.207e-06	-11.60	beta-catenin binding	molecular function	GO:0008013	107	5	18094	48	RORA,CTNND2,CDH20,CTNNA2,GLI3
9.320e-06	-11.58	plasma_cell_myeloma	COSMIC cancer mutations	plasma_cell_myeloma	1263	14	16828	49	NEBL,NTM,GPM6A,NRG3,CTNND2,PAMR1,RYR3,MACF1,FMN2,NTRK2,GLI3,ADCY2,ABLIM1,TNIK
9.320e-06	-11.58	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-plasma_cell_myeloma	1263	14	16828	49	FMN2,PAMR1,CTNND2,RYR3,MACF1,NEBL,NTM,GPM6A,NRG3,ABLIM1,TNIK,ADCY2,NTRK2,GLI3
1.053e-05	-11.46	cell junction organization	biological process	GO:0034330	532	9	18204	49	DST,GPM6A,CTNND2,NRG3,NFIA,CDH20,SPARCL1,SORBS1,PRKCA
1.167e-05	-11.36	oesophagus-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-carcinoma-squamous_cell_carcinoma	6486	34	16828	49	FBXL7,RYR3,PTPRZ1,GPC5,GPM6A,PREX2,SORBS1,NPAS3,TRPM3,MGAT4C,DST,PITPNC1,SPARCL1,TNIK,SOX5,ABLIM1,ADCY2,PARD3B,FMN2,MACF1,CSGALNACT1,CTNND2,BMPR1B,DPP10,NRG3,GLIS3,ZBTB20,SLC4A4,NEBL,ATP1A2,ITPR2,MAML2,PRKCA,GLI3
1.167e-05	-11.36	system development	biological process	GO:0048731	3533	23	18204	49	CSGALNACT1,CTNND2,TNIK,RORA,NRG3,SLC1A3,BMPR1B,CTNNA2,ATP1A2,NTRK2,NTM,PRKCA,LSAMP,GLI3,SOX5,RFX4,NEBL,GPM6A,MSI2,PTPRZ1,NFIA,PREX2,SLC1A2
1.215e-05	-11.32	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-middle_third-carcinoma-squamous_cell_carcinoma	3531	24	16828	49	ADCY2,DST,NHSL1,SPARCL1,TNIK,ABLIM1,SOX5,GPM6A,PREX2,TRPM3,RYR3,PAMR1,PTPRZ1,GPC5,MAML2,ATP1A2,NRG3,ZBTB20,SLC4A4,NEBL,FMN2,MACF1,CTNND2,DPP10
1.227e-05	-11.31	middle_third	COSMIC cancer mutations	middle_third	3533	24	16828	49	FMN2,CTNND2,MACF1,DPP10,ZBTB20,NRG3,NEBL,SLC4A4,ATP1A2,MAML2,PAMR1,PTPRZ1,RYR3,GPC5,PREX2,GPM6A,TRPM3,DST,SPARCL1,NHSL1,ABLIM1,SOX5,TNIK,ADCY2
1.359e-05	-11.21	neuron development	biological process	GO:0048666	859	11	18204	49	GLI3,NTM,PREX2,NTRK2,CTNNA2,BMPR1B,SLC1A3,PTPRZ1,TNIK,GPM6A,CTNND2
1.906e-05	-10.87	metal ion transmembrane transporter activity	molecular function	GO:0046873	442	8	18094	48	SLC1A3,RYR3,SLC4A4,SLC1A2,GPM6A,ATP1A2,TRPM3,ITPR2
1.986e-05	-10.83	Glutamatergic synapse	KEGG pathways	ko04724	114	5	7161	22	SLC1A3,ITPR2,ADCY2,SLC1A2,PRKCA
1.986e-05	-10.83	Glutamatergic synapse	KEGG pathways	hsa04724	114	5	7161	22	PRKCA,ADCY2,SLC1A2,ITPR2,SLC1A3
2.023e-05	-10.81	positive regulation of chondrocyte differentiation	biological process	GO:0032332	20	3	18204	49	SOX5,GLI3,BMPR1B
2.057e-05	-10.79	cell junction	cellular component	GO:0030054	2224	17	19108	49	NTRK2,CTNND2,PARD3B,PTPRZ1,TNIK,SLC1A2,GPM6A,DTNA,CTNNA2,SPARCL1,NFIA,DST,CDH20,NRG3,ATP1A2,SLC1A3,SORBS1
2.224e-05	-10.71	SR_plectin_7	pfam domains	PF21097	3	2	17795	49	MACF1,DST
2.276e-05	-10.69	multicellular organism development	biological process	GO:0007275	3957	24	18204	49	RFX4,PREX2,SLC1A2,NFIA,RORA,NRG3,SLC1A3,CSGALNACT1,ATP1A2,NTM,LSAMP,GLI3,CDH20,MSI2,PTPRZ1,NEBL,GPM6A,TNIK,CTNND2,NTRK2,PRKCA,SOX5,BMPR1B,CTNNA2
2.353e-05	-10.66	right_lower_lobe	COSMIC cancer mutations	right_lower_lobe	5692	31	16828	49	SLC4A4,NEBL,NRG3,DPP10,MACF1,CTNND2,FMN2,GLI3,MAML2,ITPR2,ATP1A2,DTNA,MGAT4C,NPAS3,TRPM3,GPM6A,SORBS1,NTM,GPC5,LSAMP,RYR3,PTPRZ1,PAMR1,NKAIN3,FBXL7,NTRK2,CDH20,PARD3B,ADCY2,SLC1A3,SOX5
2.353e-05	-10.66	lung-right_lower_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_lower_lobe-carcinoma-adenocarcinoma	5692	31	16828	49	DPP10,MACF1,CTNND2,FMN2,SLC4A4,NEBL,NRG3,ITPR2,ATP1A2,GLI3,MAML2,GPC5,LSAMP,RYR3,PAMR1,PTPRZ1,NKAIN3,FBXL7,DTNA,MGAT4C,NPAS3,TRPM3,SORBS1,GPM6A,NTM,SLC1A3,SOX5,NTRK2,PARD3B,CDH20,ADCY2
2.407e-05	-10.63	humerus	COSMIC cancer mutations	humerus	546	9	16828	49	GPC5,SOX5,NKAIN3,FMN2,PARD3B,NEBL,TPD52L1,ADCY2,GPM6A
2.465e-05	-10.61	bone-humerus-other-chondroblastoma	COSMIC cancer mutations	bone-humerus-other-chondroblastoma	301	7	16828	49	GPM6A,TPD52L1,ADCY2,GPC5,SOX5,NKAIN3,FMN2
3.254e-05	-10.33	autonomic_ganglia	COSMIC cancer mutations	autonomic_ganglia	4005	25	16828	49	NFIA,MAML2,GLI3,ATP1A2,RFX4,GLIS3,NEBL,SLC4A4,FMN2,CTNND2,MACF1,DPP10,ADCY2,PARD3B,NTRK2,PITPNC1,NHSL1,TNIK,GPM6A,PREX2,NPAS3,SLC1A2,FBXL7,PTPRZ1,RYR3
3.402e-05	-10.29	skin-face-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-face-carcinoma-squamous_cell_carcinoma	2036	17	16828	49	TRPM3,GPM6A,PREX2,NRG3,NEBL,MACF1,CSGALNACT1,PTPRZ1,GPC5,LSAMP,DPP10,FMN2,MSI2,RORA,ITPR2,ABLIM1,DST
3.484e-05	-10.26	OCLN (occludin)	protein interactions	100506658	495	8	19454	50	DST,ABLIM1,PRKCA,DTNA,FMN2,MACF1,NTRK2,TNIK
3.641e-05	-10.22	nasopharyngeal_carcinoma	COSMIC cancer mutations	nasopharyngeal_carcinoma	1425	14	16828	49	NFIA,NTRK2,PRKCA,ATP1A2,NHSL1,PITPNC1,DST,SLC4A4,RFX4,PREX2,FMN2,SLC1A2,DPP10,CTNND2
3.641e-05	-10.22	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-nasopharyngeal_carcinoma	1425	14	16828	49	NFIA,PRKCA,NTRK2,DST,PITPNC1,NHSL1,ATP1A2,PREX2,RFX4,SLC4A4,SLC1A2,FMN2,CTNND2,DPP10
4.197e-05	-10.08	neuron projection morphogenesis	biological process	GO:0048812	486	8	18204	49	CTNNA2,GPM6A,BMPR1B,CTNND2,PTPRZ1,GLI3,TNIK,PREX2
4.271e-05	-10.06	PCN-like_spectrin-like_rpt	interpro domains	IPR049538	4	2	18521	50	DST,MACF1
4.271e-05	-10.06	Desmoplakin_Spectrin-like	interpro domains	IPR041573	4	2	18521	50	MACF1,DST
4.441e-05	-10.02	Spectrin_2	pfam domains	PF18373	4	2	17795	49	MACF1,DST
4.441e-05	-10.02	Spectrin_4	pfam domains	PF21020	4	2	17795	49	MACF1,DST
4.441e-05	-10.02	Spectrin_3	pfam domains	PF21019	4	2	17795	49	MACF1,DST
4.512e-05	-10.01	plasma membrane bounded cell projection morphogenesis	biological process	GO:0120039	491	8	18204	49	PREX2,TNIK,GLI3,PTPRZ1,CTNND2,BMPR1B,GPM6A,CTNNA2
4.590e-05	-9.99	Neurotransmitter uptake and Metabolism In Glial Cells	REACTOME pathways	R-HSA-112313	4	2	10285	29	SLC1A3,SLC1A2
4.590e-05	-9.99	Astrocytic Glutamate-Glutamine Uptake And Metabolism	REACTOME pathways	R-HSA-210455	4	2	10285	29	SLC1A3,SLC1A2
4.687e-05	-9.97	lung-carcinoma-small_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-small_cell_carcinoma	9908	42	16828	49	FBXL7,NKAIN3,PAMR1,PTPRZ1,RYR3,GPC5,NTM,SORBS1,GPM6A,PREX2,TRPM3,NPAS3,MGAT4C,DTNA,PITPNC1,DST,SPARCL1,SOX5,ABLIM1,TNIK,MSI2,CDH20,PARD3B,NTRK2,FMN2,CTNND2,CSGALNACT1,MACF1,BMPR1B,DPP10,RFX4,NRG3,TPD52L1,NEBL,SLC4A4,ATP1A2,ITPR2,NFIA,RORA,MAML2,GLI3,PRKCA
4.765e-05	-9.95	small_cell_carcinoma	COSMIC cancer mutations	small_cell_carcinoma	9913	42	16828	49	PITPNC1,DST,SPARCL1,ABLIM1,SOX5,TNIK,MSI2,CDH20,PARD3B,NTRK2,FBXL7,NKAIN3,PAMR1,PTPRZ1,RYR3,GPC5,NTM,PREX2,SORBS1,GPM6A,TRPM3,NPAS3,MGAT4C,DTNA,ATP1A2,ITPR2,NFIA,RORA,MAML2,GLI3,PRKCA,FMN2,CSGALNACT1,CTNND2,MACF1,BMPR1B,DPP10,RFX4,TPD52L1,NRG3,NEBL,SLC4A4
4.847e-05	-9.93	cell projection morphogenesis	biological process	GO:0048858	496	8	18204	49	PREX2,TNIK,GLI3,PTPRZ1,CTNND2,BMPR1B,GPM6A,CTNNA2
4.917e-05	-9.92	-	gene3d domains	1.20.58.1060	4	2	14470	42	MACF1,DST
5.135e-05	-9.88	lung-right_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-right_upper_lobe-carcinoma-adenocarcinoma	10376	43	16828	49	NFIA,PRKCA,ATP1A2,ITPR2,NEBL,BMPR1B,MACF1,CSGALNACT1,ADCY2,NTRK2,CDH20,DST,PITPNC1,SLC1A3,TNIK,SOX5,GPM6A,PREX2,NTM,MGAT4C,NPAS3,TRPM3,NKAIN3,FBXL7,SLC1A2,LSAMP,PTPRZ1,RORA,GLI3,SLC4A4,NRG3,RFX4,ZBTB20,GLIS3,FMN2,CTNND2,PARD3B,ABLIM1,SORBS1,DTNA,GPC5,RYR3,PAMR1
5.135e-05	-9.88	right_upper_lobe	COSMIC cancer mutations	right_upper_lobe	10376	43	16828	49	NTRK2,CDH20,ADCY2,SLC1A3,SOX5,TNIK,PITPNC1,DST,MGAT4C,TRPM3,NPAS3,NTM,GPM6A,PREX2,LSAMP,PTPRZ1,NKAIN3,SLC1A2,FBXL7,PRKCA,NFIA,ITPR2,ATP1A2,NEBL,BMPR1B,CSGALNACT1,MACF1,PARD3B,ABLIM1,DTNA,SORBS1,GPC5,PAMR1,RYR3,GLI3,RORA,SLC4A4,RFX4,GLIS3,ZBTB20,NRG3,CTNND2,FMN2
5.275e-05	-9.85	central nervous system development	biological process	GO:0007417	995	11	18204	49	RFX4,PTPRZ1,MSI2,SLC1A2,NRG3,RORA,CTNNA2,BMPR1B,GLI3,NTRK2,ATP1A2
5.352e-05	-9.84	EZR (ezrin)	protein interactions	7430	526	8	19454	50	TNIK,SORBS1,MACF1,NEBL,DTNA,ABLIM1,PRKCA,DST
6.426e-05	-9.65	face	COSMIC cancer mutations	face	2139	17	16828	49	TRPM3,NEBL,NRG3,GPM6A,PREX2,DPP10,LSAMP,GPC5,CSGALNACT1,PTPRZ1,MACF1,FMN2,RORA,MSI2,ABLIM1,ITPR2,DST
6.676e-05	-9.61	Thyroid hormone synthesis	KEGG pathways	hsa04918	74	4	7161	22	PRKCA,ATP1A2,ADCY2,ITPR2
6.676e-05	-9.61	Thyroid hormone synthesis	KEGG pathways	ko04918	74	4	7161	22	ATP1A2,ADCY2,PRKCA,ITPR2
6.856e-05	-9.59	high-affinity L-glutamate transmembrane transporter activity	molecular function	GO:0005314	5	2	18094	48	SLC1A3,SLC1A2
6.856e-05	-9.59	glutamate:sodium symporter activity	molecular function	GO:0015501	5	2	18094	48	SLC1A2,SLC1A3
6.943e-05	-9.58	stress fiber	cellular component	GO:0001725	86	4	19108	49	ABLIM1,NEBL,DST,SORBS1
6.943e-05	-9.58	contractile actin filament bundle	cellular component	GO:0097517	86	4	19108	49	SORBS1,ABLIM1,DST,NEBL
7.038e-05	-9.56	Gastric acid secretion	KEGG pathways	ko04971	75	4	7161	22	ITPR2,PRKCA,ADCY2,ATP1A2
7.038e-05	-9.56	Gastric acid secretion	KEGG pathways	hsa04971	75	4	7161	22	ITPR2,ADCY2,ATP1A2,PRKCA
7.061e-05	-9.56	D-aspartate transmembrane transport	biological process	GO:0070777	5	2	18204	49	SLC1A3,SLC1A2
7.061e-05	-9.56	D-aspartate import across plasma membrane	biological process	GO:0070779	5	2	18204	49	SLC1A2,SLC1A3
7.070e-05	-9.56	neurotransmitter uptake	biological process	GO:0001504	30	3	18204	49	SLC1A3,SLC1A2,ATP1A2
7.145e-05	-9.55	nodular	COSMIC cancer mutations	nodular	1515	14	16828	49	CDH20,NTRK2,ABLIM1,ATP1A2,SPARCL1,NPAS3,PREX2,GLIS3,SLC4A4,NEBL,MACF1,PTPRZ1,CTNND2,FMN2
7.937e-05	-9.44	prostate	COSMIC cancer mutations	prostate	13883	49	16828	49	PARD3B,MSI2,ABLIM1,DTNA,SORBS1,GPC5,PAMR1,RYR3,GLI3,RORA,SLC4A4,ZBTB20,GLIS3,RFX4,NRG3,TPD52L1,DPP10,CTNND2,FMN2,NTRK2,CDH20,ADCY2,SLC1A3,SOX5,TNIK,SPARCL1,NHSL1,PITPNC1,DST,MGAT4C,TRPM3,NPAS3,NTM,PREX2,GPM6A,LSAMP,PTPRZ1,NKAIN3,SLC1A2,FBXL7,PRKCA,MAML2,NFIA,ITPR2,ATP1A2,NEBL,BMPR1B,CSGALNACT1,MACF1
8.255e-05	-9.40	NTM (neurotrimin)	protein interactions	50863	33	3	19454	50	LSAMP,NTM,GPM6A
8.364e-05	-9.39	transport across blood-brain barrier	biological process	GO:0150104	86	4	18204	49	ATP1A2,SLC1A2,SLC1A3,SLC4A4
8.364e-05	-9.39	vascular transport	biological process	GO:0010232	86	4	18204	49	SLC4A4,SLC1A3,SLC1A2,ATP1A2
8.604e-05	-9.36	positive regulation of cartilage development	biological process	GO:0061036	32	3	18204	49	BMPR1B,GLI3,SOX5
8.887e-05	-9.33	anatomical structure development	biological process	GO:0048856	5207	27	18204	49	CTNND2,TNIK,CTNNA2,BMPR1B,SOX5,PRKCA,FMN2,NTRK2,GPM6A,NEBL,PTPRZ1,MSI2,ABLIM1,CSGALNACT1,SLC1A3,NRG3,RORA,CDH20,LSAMP,GLI3,NTM,ATP1A2,RFX4,NFIA,SPARCL1,SLC1A2,PREX2
9.033e-05	-9.31	actomyosin	cellular component	GO:0042641	92	4	19108	49	NEBL,DST,ABLIM1,SORBS1
9.307e-05	-9.28	telencephalon development	biological process	GO:0021537	276	6	18204	49	RFX4,NRG3,SLC1A2,NTRK2,ATP1A2,GLI3
9.314e-05	-9.28	autonomic_ganglia-neuroblastoma	COSMIC cancer mutations	autonomic_ganglia-neuroblastoma	3970	24	16828	49	ATP1A2,GLI3,NFIA,MAML2,CTNND2,MACF1,DPP10,FMN2,RFX4,GLIS3,NEBL,SLC4A4,TNIK,PITPNC1,PARD3B,NTRK2,ADCY2,PTPRZ1,RYR3,SLC1A2,FBXL7,NPAS3,GPM6A,PREX2
9.354e-05	-9.28	neuroblastoma	COSMIC cancer mutations	neuroblastoma	3971	24	16828	49	RFX4,GLIS3,SLC4A4,NEBL,MACF1,CTNND2,DPP10,FMN2,GLI3,NFIA,MAML2,ATP1A2,NPAS3,GPM6A,PREX2,RYR3,PTPRZ1,FBXL7,SLC1A2,PARD3B,NTRK2,ADCY2,TNIK,PITPNC1
9.946e-05	-9.22	cartilage development	biological process	GO:0051216	173	5	18204	49	SOX5,GLI3,BMPR1B,CSGALNACT1,NFIA
1.057e-04	-9.15	mammary gland formation	biological process	GO:0060592	6	2	18204	49	NRG3,GLI3
1.057e-04	-9.15	L-aspartate import across plasma membrane	biological process	GO:0140009	6	2	18204	49	SLC1A3,SLC1A2
1.057e-04	-9.15	D-amino acid transport	biological process	GO:0042940	6	2	18204	49	SLC1A2,SLC1A3
1.064e-04	-9.15	Ins145_P3_rcpt	interpro domains	IPR014821	6	2	18521	50	ITPR2,RYR3
1.064e-04	-9.15	Desmoplakin_SH3	interpro domains	IPR041615	6	2	18521	50	MACF1,DST
1.064e-04	-9.15	RIH_dom	interpro domains	IPR000699	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	GAR_dom	interpro domains	IPR003108	6	2	18521	50	DST,MACF1
1.064e-04	-9.15	RyR/IP3R_RIH_dom_sf	interpro domains	IPR035910	6	2	18521	50	ITPR2,RYR3
1.064e-04	-9.15	GAR_dom_sf	interpro domains	IPR036534	6	2	18521	50	MACF1,DST
1.064e-04	-9.15	Ryanodine_IP3_receptor	interpro domains	IPR015925	6	2	18521	50	ITPR2,RYR3
1.064e-04	-9.15	RIH_assoc-dom	interpro domains	IPR013662	6	2	18521	50	RYR3,ITPR2
1.064e-04	-9.15	GLI-like	interpro domains	IPR043359	6	2	18521	50	GLIS3,GLI3
1.066e-04	-9.15	actin filament bundle	cellular component	GO:0032432	96	4	19108	49	SORBS1,DST,NEBL,ABLIM1
1.106e-04	-9.11	RIH_assoc	pfam domains	PF08454	6	2	17795	49	RYR3,ITPR2
1.106e-04	-9.11	SH3_10	pfam domains	PF17902	6	2	17795	49	DST,MACF1
1.106e-04	-9.11	Plectin	pfam domains	PF00681	6	2	17795	49	MACF1,DST
1.106e-04	-9.11	GAS2	pfam domains	PF02187	6	2	17795	49	DST,MACF1
1.106e-04	-9.11	Ins145_P3_rec	pfam domains	PF08709	6	2	17795	49	ITPR2,RYR3
1.106e-04	-9.11	RYDR_ITPR	pfam domains	PF01365	6	2	17795	49	ITPR2,RYR3
1.110e-04	-9.11	cell junction assembly	biological process	GO:0034329	285	6	18204	49	NRG3,PRKCA,CDH20,SORBS1,DST,GPM6A
1.137e-04	-9.08	DAG and IP3 signaling	REACTOME pathways	R-HSA-1489509	34	3	10285	29	ADCY2,PRKCA,ITPR2
1.149e-04	-9.07	plasma membrane bounded cell projection	cellular component	GO:0120025	2285	16	19108	49	ADCY2,PRKCA,CTNND2,NTRK2,MACF1,GPM6A,SLC1A2,GLI3,CTNNA2,DTNA,BMPR1B,SLC1A3,ATP1A2,ABLIM1,FMN2,DST
1.173e-04	-9.05	adherens junction	cellular component	GO:0005912	188	5	19108	49	SORBS1,PARD3B,CTNND2,CTNNA2,CDH20
1.219e-04	-9.01	tibia	COSMIC cancer mutations	tibia	836	10	16828	49	TRPM3,PREX2,GPM6A,LSAMP,MACF1,TNIK,CTNND2,ABLIM1,NKAIN3,DST
1.225e-04	-9.01	IP3 receptor type 1 binding core, RIH domain	gene3d domains	1.25.10.30	6	2	14470	42	ITPR2,RYR3
1.225e-04	-9.01	Plakin repeat	gene3d domains	3.90.1290.10	6	2	14470	42	MACF1,DST
1.225e-04	-9.01	Gas2-like domain	gene3d domains	3.30.920.20	6	2	14470	42	MACF1,DST
1.352e-04	-8.91	PLC-gamma1 signalling	REACTOME pathways	R-HSA-167021	36	3	10285	29	ITPR2,PRKCA,ADCY2
1.352e-04	-8.91	EGFR interacts with phospholipase C-gamma	REACTOME pathways	R-HSA-212718	36	3	10285	29	ITPR2,PRKCA,ADCY2
1.367e-04	-8.90	follicular_lymphoma	COSMIC cancer mutations	follicular_lymphoma	1209	12	16828	49	TNIK,ITPR2,SOX5,RORA,ADCY2,PRKCA,NKAIN3,GPC5,DPP10,LSAMP,CTNND2,NRG3
1.370e-04	-8.90	actin binding	molecular function	GO:0003779	434	7	18094	48	ABLIM1,NEBL,SORBS1,FMN2,DST,MACF1,CTNNA2
1.374e-04	-8.89	C11orf52 (chromosome 11 open reading frame 52)	protein interactions	91894	310	6	19454	50	FMN2,TNIK,DTNA,ABLIM1,MACF1,DST
1.437e-04	-8.85	inorganic cation transmembrane transporter activity	molecular function	GO:0022890	589	8	18094	48	ITPR2,TRPM3,RYR3,SLC1A3,ATP1A2,GPM6A,SLC1A2,SLC4A4
1.469e-04	-8.83	HUNK (hormonally up-regulated Neu-associated kinase)	protein interactions	30811	104	4	19454	50	DST,ABLIM1,SORBS1,SPARCL1
1.487e-04	-8.81	Plakin_repeat_sf	interpro domains	IPR035915	7	2	18521	50	DST,MACF1
1.487e-04	-8.81	Na-dicarboxylate_symporter_CS	interpro domains	IPR018107	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Na:dicarbo_symporter_sf	interpro domains	IPR036458	7	2	18521	50	SLC1A2,SLC1A3
1.487e-04	-8.81	Plectin_repeat	interpro domains	IPR001101	7	2	18521	50	MACF1,DST
1.487e-04	-8.81	Na-dicarboxylate_symporter	interpro domains	IPR001991	7	2	18521	50	SLC1A2,SLC1A3
1.490e-04	-8.81	FLOT1 (flotillin 1)	protein interactions	10211	453	7	19454	50	SOX5,SORBS1,MACF1,FMN2,DTNA,ABLIM1,DST
1.546e-04	-8.77	SDF	pfam domains	PF00375	7	2	17795	49	SLC1A2,SLC1A3
1.563e-04	-8.76	GAR	prosite domains	PS51460	6	2	12186	40	MACF1,DST
1.565e-04	-8.76	cellular response to alkaloid	biological process	GO:0071312	39	3	18204	49	SLC1A3,SLC1A2,RYR3
1.625e-04	-8.72	stomach-carcinoma-intestinal_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-intestinal_adenocarcinoma	7225	34	16828	49	SLC1A2,FBXL7,PTPRZ1,RYR3,LSAMP,NTM,PREX2,TRPM3,NPAS3,PITPNC1,DST,NHSL1,SOX5,ADCY2,CDH20,PARD3B,NTRK2,FMN2,CTNND2,CSGALNACT1,MACF1,DPP10,ZBTB20,RFX4,NRG3,NEBL,SLC4A4,ATP1A2,ITPR2,NFIA,RORA,MAML2,PRKCA,GLI3
1.625e-04	-8.72	intestinal_adenocarcinoma	COSMIC cancer mutations	intestinal_adenocarcinoma	7225	34	16828	49	GLI3,PRKCA,RORA,MAML2,NFIA,ITPR2,ATP1A2,SLC4A4,NEBL,NRG3,RFX4,ZBTB20,DPP10,MACF1,CTNND2,CSGALNACT1,FMN2,NTRK2,CDH20,PARD3B,ADCY2,SOX5,NHSL1,DST,PITPNC1,NPAS3,TRPM3,PREX2,NTM,LSAMP,RYR3,PTPRZ1,FBXL7,SLC1A2
1.687e-04	-8.69	developmental process	biological process	GO:0032502	5716	28	18204	49	RFX4,PREX2,SLC1A2,SPARCL1,NFIA,RORA,NRG3,SLC1A3,CSGALNACT1,ATP1A2,NTM,GLI3,LSAMP,CDH20,MSI2,PTPRZ1,NEBL,GPM6A,ABLIM1,NHSL1,TNIK,CTNND2,NTRK2,FMN2,PRKCA,SOX5,BMPR1B,CTNNA2
1.707e-04	-8.68	cell adhesion	biological process	GO:0007155	942	10	18204	49	CTNND2,DST,SPARCL1,SORBS1,PARD3B,CDH20,CTNNA2,NTM,LSAMP,PRKCA
1.711e-04	-8.67	Sodium:dicarboxylate symporter	gene3d domains	1.10.3860.10	7	2	14470	42	SLC1A2,SLC1A3
1.712e-04	-8.67	cell morphogenesis involved in neuron differentiation	biological process	GO:0048667	443	7	18204	49	CTNNA2,BMPR1B,GLI3,PREX2,CTNND2,SLC1A3,PTPRZ1
1.762e-04	-8.64	pancreas-carcinoid-endocrine_tumour	COSMIC cancer mutations	pancreas-carcinoid-endocrine_tumour	7250	34	16828	49	SLC1A2,FBXL7,NKAIN3,PAMR1,RYR3,LSAMP,GPC5,GPM6A,PREX2,NHSL1,SOX5,ABLIM1,SLC1A3,ADCY2,CDH20,NTRK2,FMN2,CSGALNACT1,CTNND2,MACF1,DPP10,BMPR1B,GLIS3,RFX4,TPD52L1,NRG3,NEBL,SLC4A4,ATP1A2,ITPR2,MAML2,RORA,GLI3,PRKCA
1.814e-04	-8.62	neural precursor cell proliferation	biological process	GO:0061351	105	4	18204	49	SOX5,GLI3,RORA,NFIA
1.874e-04	-8.58	GAS2	smart domains	SM00243	6	2	9717	35	DST,MACF1
1.874e-04	-8.58	bone-tibia-other-chondroblastoma	COSMIC cancer mutations	bone-tibia-other-chondroblastoma	98	4	16828	49	CTNND2,LSAMP,GPM6A,NKAIN3
1.979e-04	-8.53	Plakin	interpro domains	IPR043197	8	2	18521	50	MACF1,DST
2.035e-04	-8.50	cell projection	cellular component	GO:0042995	2398	16	19108	49	GPM6A,SLC1A2,ADCY2,PRKCA,CTNND2,MACF1,NTRK2,SLC1A3,ATP1A2,ABLIM1,FMN2,DST,CTNNA2,GLI3,DTNA,BMPR1B
2.183e-04	-8.43	NA_DICARBOXYL_SYMP_2	prosite domains	PS00714	7	2	12186	40	SLC1A3,SLC1A2
2.183e-04	-8.43	NA_DICARBOXYL_SYMP_1	prosite domains	PS00713	7	2	12186	40	SLC1A3,SLC1A2
2.273e-04	-8.39	cellular response to organic cyclic compound	biological process	GO:0071407	464	7	18204	49	RYR3,ADCY2,SLC1A3,ITPR2,ATP1A2,RORA,SLC1A2
2.276e-04	-8.39	monoatomic cation transmembrane transporter activity	molecular function	GO:0008324	630	8	18094	48	SLC4A4,SLC1A2,GPM6A,ATP1A2,SLC1A3,RYR3,TRPM3,ITPR2
2.304e-04	-8.38	NEGR1 (neuronal growth regulator 1)	protein interactions	257194	9	2	19454	50	LSAMP,NTM
2.304e-04	-8.38	LSAMP (limbic system associated membrane protein)	protein interactions	4045	9	2	19454	50	NTM,LSAMP
2.402e-04	-8.33	acidic amino acid transport	biological process	GO:0015800	45	3	18204	49	NTRK2,SLC1A2,SLC1A3
2.531e-04	-8.28	skin-trunk-malignant_melanoma-nodular	COSMIC cancer mutations	skin-trunk-malignant_melanoma-nodular	1291	12	16828	49	GLIS3,PREX2,NEBL,NPAS3,PTPRZ1,CTNND2,MACF1,CDH20,NTRK2,SPARCL1,ATP1A2,ABLIM1
2.594e-04	-8.26	calcium channel activity	molecular function	GO:0005262	117	4	18094	48	ITPR2,RYR3,TRPM3,GPM6A
2.601e-04	-8.25	EDTRNSPORT	prints domains	PR00173	7	2	5227	19	SLC1A2,SLC1A3
2.617e-04	-8.25	PLEC	smart domains	SM00250	7	2	9717	35	MACF1,DST
2.864e-04	-8.16	SFN (stratifin)	protein interactions	2810	671	8	19454	50	DST,ABLIM1,NFIA,FMN2,MACF1,SORBS1,TNIK,PARD3B
2.955e-04	-8.13	prostate-carcinoma-adenocarcinoma	COSMIC cancer mutations	prostate-carcinoma-adenocarcinoma	12379	46	16828	49	RORA,GLI3,TPD52L1,NRG3,GLIS3,RFX4,ZBTB20,FMN2,CTNND2,DPP10,PARD3B,ABLIM1,SORBS1,RYR3,PAMR1,GPC5,NFIA,MAML2,PRKCA,ATP1A2,ITPR2,NEBL,MACF1,CSGALNACT1,BMPR1B,ADCY2,CDH20,NTRK2,DST,PITPNC1,NHSL1,SPARCL1,TNIK,SOX5,SLC1A3,GPM6A,PREX2,NTM,NPAS3,TRPM3,MGAT4C,FBXL7,SLC1A2,NKAIN3,PTPRZ1,LSAMP
3.007e-04	-8.11	PLC beta mediated events	REACTOME pathways	R-HSA-112043	47	3	10285	29	PRKCA,ADCY2,ITPR2
3.150e-04	-8.06	neuronal action potential propagation	biological process	GO:0019227	10	2	18204	49	NTRK2,ATP1A2
3.150e-04	-8.06	action potential propagation	biological process	GO:0098870	10	2	18204	49	ATP1A2,NTRK2
3.150e-04	-8.06	cellular response to cocaine	biological process	GO:0071314	10	2	18204	49	SLC1A3,SLC1A2
3.162e-04	-8.06	EPB41L4A (erythrocyte membrane protein band 4.1 like 4A)	protein interactions	64097	127	4	19454	50	ABLIM1,MACF1,DST,DTNA
3.170e-04	-8.06	MIR_dom_sf	interpro domains	IPR036300	10	2	18521	50	ITPR2,RYR3
3.170e-04	-8.06	MIR_motif	interpro domains	IPR016093	10	2	18521	50	RYR3,ITPR2
3.201e-04	-8.05	G-protein mediated events	REACTOME pathways	R-HSA-112040	48	3	10285	29	ADCY2,PRKCA,ITPR2
3.234e-04	-8.04	upper_aerodigestive_tract-mouth-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma	6426	31	16828	49	GPC5,RYR3,PAMR1,FBXL7,SLC1A2,MGAT4C,NPAS3,TRPM3,PREX2,SORBS1,GPM6A,NTM,SLC1A3,SOX5,ABLIM1,NHSL1,DST,PITPNC1,PARD3B,CDH20,ADCY2,MACF1,CTNND2,FMN2,SLC4A4,NRG3,RFX4,ZBTB20,GLI3,RORA,MAML2
3.244e-04	-8.03	bone	COSMIC cancer mutations	bone	8157	36	16828	49	PARD3B,NTRK2,ADCY2,ABLIM1,SOX5,TNIK,SLC1A3,DST,SPARCL1,TRPM3,NPAS3,DTNA,GPM6A,SORBS1,PREX2,PTPRZ1,PAMR1,RYR3,LSAMP,GPC5,NKAIN3,GLI3,RORA,MAML2,ITPR2,ATP1A2,ZBTB20,GLIS3,NRG3,TPD52L1,NEBL,SLC4A4,CSGALNACT1,CTNND2,MACF1,FMN2
3.296e-04	-8.02	MIR	pfam domains	PF02815	10	2	17795	49	ITPR2,RYR3
3.346e-04	-8.00	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	COSMIC cancer mutations	central_nervous_system-brainstem-glioma-oligoastrocytoma_Grade_III	114	4	16828	49	RYR3,SOX5,PREX2,SLC1A2
3.387e-04	-7.99	actin cytoskeleton	cellular component	GO:0015629	520	7	19108	49	ABLIM1,FMN2,MACF1,NEBL,DST,SORBS1,CTNNA2
3.508e-04	-7.96	ADCY5 (adenylate cyclase 5)	protein interactions	111	11	2	19454	50	PRKCA,ADCY2
3.844e-04	-7.86	L-glutamate import across plasma membrane	biological process	GO:0098712	11	2	18204	49	SLC1A3,SLC1A2
3.844e-04	-7.86	L-aspartate transmembrane transport	biological process	GO:0070778	11	2	18204	49	SLC1A3,SLC1A2
3.889e-04	-7.85	connective tissue development	biological process	GO:0061448	232	5	18204	49	GLI3,SOX5,NFIA,BMPR1B,CSGALNACT1
3.906e-04	-7.85	regulation of chondrocyte differentiation	biological process	GO:0032330	53	3	18204	49	SOX5,GLI3,BMPR1B
3.988e-04	-7.83	NTRK2 (neurotrophic receptor tyrosine kinase 2)	protein interactions	4915	135	4	19454	50	DTNA,DST,NTRK2,ABLIM1
4.043e-04	-7.81	basal_(triple-negative)_carcinoma	COSMIC cancer mutations	basal_(triple-negative)_carcinoma	2981	19	16828	49	NTRK2,GLI3,PRKCA,MAML2,ADCY2,MSI2,SPARCL1,ATP1A2,DST,TRPM3,NPAS3,NEBL,SLC4A4,NTM,NRG3,DPP10,BMPR1B,MACF1,FMN2
4.043e-04	-7.81	breast-carcinoma-basal_(triple-negative)_carcinoma	COSMIC cancer mutations	breast-carcinoma-basal_(triple-negative)_carcinoma	2981	19	16828	49	MAML2,MSI2,ADCY2,NTRK2,GLI3,PRKCA,SPARCL1,ATP1A2,DST,NEBL,SLC4A4,NTM,NRG3,TRPM3,NPAS3,FMN2,DPP10,BMPR1B,MACF1
4.282e-04	-7.76	haematopoietic_and_lymphoid_tissue	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue	14368	49	16828	49	FBXL7,SLC1A2,NKAIN3,PTPRZ1,LSAMP,GPM6A,PREX2,NTM,NPAS3,TRPM3,MGAT4C,DST,PITPNC1,NHSL1,SPARCL1,TNIK,SOX5,SLC1A3,ADCY2,CDH20,NTRK2,MACF1,CSGALNACT1,BMPR1B,NEBL,ATP1A2,ITPR2,NFIA,MAML2,PRKCA,RYR3,PAMR1,GPC5,SORBS1,DTNA,ABLIM1,MSI2,PARD3B,FMN2,CTNND2,DPP10,NRG3,TPD52L1,GLIS3,RFX4,ZBTB20,SLC4A4,RORA,GLI3
4.301e-04	-7.75	LYN (LYN proto-oncogene, Src family tyrosine kinase)	protein interactions	4067	713	8	19454	50	TNIK,SLC1A3,MACF1,MSI2,FMN2,DTNA,ABLIM1,DST
4.439e-04	-7.72	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-follicular_lymphoma	981	10	16828	49	PRKCA,NRG3,ADCY2,RORA,ITPR2,CTNND2,SOX5,GPC5,LSAMP,NKAIN3
4.466e-04	-7.71	neuron projection	cellular component	GO:0043005	1331	11	19108	49	CTNND2,ADCY2,NTRK2,GPM6A,SLC1A2,CTNNA2,DTNA,BMPR1B,ATP1A2,SLC1A3,DST
4.593e-04	-7.69	haematopoietic_neoplasm	COSMIC cancer mutations	haematopoietic_neoplasm	11082	43	16828	49	NEBL,SLC4A4,RFX4,GLIS3,NRG3,FMN2,BMPR1B,DPP10,CSGALNACT1,CTNND2,MACF1,MAML2,RORA,NFIA,PRKCA,GLI3,ATP1A2,ITPR2,NTM,PREX2,DTNA,TRPM3,NPAS3,NKAIN3,SLC1A2,FBXL7,LSAMP,GPC5,PAMR1,PTPRZ1,RYR3,MSI2,ADCY2,NTRK2,CDH20,PARD3B,SPARCL1,NHSL1,DST,SLC1A3,SOX5,ABLIM1,TNIK
4.598e-04	-7.68	calcium ion transmembrane transporter activity	molecular function	GO:0015085	136	4	18094	48	ITPR2,RYR3,TRPM3,GPM6A
4.650e-04	-7.67	MIR	prosite domains	PS50919	10	2	12186	40	RYR3,ITPR2
4.796e-04	-7.64	neuron projection development	biological process	GO:0031175	693	8	18204	49	GPM6A,CTNNA2,CTNND2,BMPR1B,GLI3,PTPRZ1,PREX2,TNIK
4.895e-04	-7.62	trunk	COSMIC cancer mutations	trunk	3554	21	16828	49	MGAT4C,NPAS3,NEBL,PREX2,NRG3,GLIS3,DPP10,LSAMP,MACF1,RYR3,PTPRZ1,CTNND2,NTRK2,CDH20,MAML2,SLC1A3,SOX5,ABLIM1,ATP1A2,SPARCL1,DST
5.053e-04	-7.59	Ion homeostasis	REACTOME pathways	R-HSA-5578775	56	3	10285	29	RYR3,ITPR2,ATP1A2
5.090e-04	-7.58	Calml3 (calmodulin-like 3)	protein interactions	70405	144	4	19454	50	DST,MACF1,ABLIM1,ZBTB20
5.199e-04	-7.56	CTNNB1 (catenin beta 1)	protein interactions	1499	926	9	19454	50	PARD3B,SORBS1,PTPRZ1,DTNA,NHSL1,DST,CTNNA2,CTNND2,PRKCA
5.266e-04	-7.55	inorganic molecular entity transmembrane transporter activity	molecular function	GO:0015318	714	8	18094	48	RYR3,SLC1A3,GPM6A,ATP1A2,SLC4A4,SLC1A2,TRPM3,ITPR2
5.507e-04	-7.50	cell development	biological process	GO:0048468	2236	15	18204	49	PTPRZ1,MSI2,NEBL,GPM6A,PREX2,SLC1A3,TNIK,RORA,CTNND2,GLI3,NTRK2,NTM,FMN2,CTNNA2,BMPR1B
5.545e-04	-7.50	ductolobular_carcinoma	COSMIC cancer mutations	ductolobular_carcinoma	1619	13	16828	49	PTPRZ1,CTNND2,MACF1,DPP10,FMN2,DTNA,PREX2,SORBS1,ABLIM1,PARD3B,CDH20,GLI3,RORA
5.545e-04	-7.50	breast-carcinoma-ductolobular_carcinoma	COSMIC cancer mutations	breast-carcinoma-ductolobular_carcinoma	1619	13	16828	49	DTNA,SORBS1,PREX2,DPP10,MACF1,CTNND2,PTPRZ1,FMN2,CDH20,PARD3B,GLI3,RORA,ABLIM1
5.570e-04	-7.49	MIR	smart domains	SM00472	10	2	9717	35	ITPR2,RYR3
6.104e-04	-7.40	VCL (vinculin)	protein interactions	7414	268	5	19454	50	NEBL,DST,MACF1,PRKCA,SORBS1
6.145e-04	-7.39	L-glutamate transmembrane transporter activity	molecular function	GO:0005313	14	2	18094	48	SLC1A3,SLC1A2
6.327e-04	-7.37	sodium ion export across plasma membrane	biological process	GO:0036376	14	2	18204	49	SLC4A4,ATP1A2
6.388e-04	-7.36	CDH1 (cadherin 1)	protein interactions	999	757	8	19454	50	CTNNA2,DST,ABLIM1,CTNND2,NHSL1,NEBL,MACF1,SORBS1
6.401e-04	-7.35	brain development	biological process	GO:0007420	724	8	18204	49	ATP1A2,NTRK2,SLC1A2,GLI3,CTNNA2,RORA,NRG3,RFX4
6.409e-04	-7.35	EF-hand-dom_pair	interpro domains	IPR011992	258	5	18521	50	SPARCL1,DST,MACF1,DTNA,RYR3
6.412e-04	-7.35	cell adhesion molecule binding	molecular function	GO:0050839	560	7	18094	48	CDH20,PRKCA,PTPRZ1,DST,CTNNA2,MACF1,CTNND2
6.542e-04	-7.33	upper_aerodigestive_tract	COSMIC cancer mutations	upper_aerodigestive_tract	13181	47	16828	49	NRG3,ZBTB20,GLIS3,RFX4,SLC4A4,FMN2,CTNND2,DPP10,RORA,GLI3,SORBS1,DTNA,RYR3,PAMR1,GPC5,MSI2,PARD3B,ABLIM1,NEBL,MACF1,CSGALNACT1,BMPR1B,NFIA,MAML2,PRKCA,ATP1A2,ITPR2,PREX2,GPM6A,NTM,NPAS3,TRPM3,MGAT4C,FBXL7,SLC1A2,NKAIN3,PTPRZ1,LSAMP,ADCY2,CDH20,NTRK2,DST,PITPNC1,NHSL1,TNIK,SOX5,SLC1A3
6.642e-04	-7.32	ACTB (actin beta)	protein interactions	60	958	9	19454	50	DST,PRKCA,ABLIM1,DTNA,FMN2,NHSL1,NEBL,MACF1,SORBS1
6.803e-04	-7.29	dendrite morphogenesis	biological process	GO:0048813	64	3	18204	49	CTNND2,CTNNA2,PREX2
6.850e-04	-7.29	scalp	COSMIC cancer mutations	scalp	2110	15	16828	49	NFIA,RORA,DST,ATP1A2,SOX5,SORBS1,PREX2,NTM,SLC4A4,NEBL,FMN2,MACF1,PTPRZ1,GPC5,LSAMP
7.031e-04	-7.26	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	6023	29	16828	49	PREX2,TRPM3,NPAS3,DTNA,NKAIN3,PTPRZ1,PAMR1,RYR3,ADCY2,NTRK2,DST,SPARCL1,ABLIM1,SOX5,SLC1A3,GLIS3,ZBTB20,TPD52L1,NRG3,NEBL,SLC4A4,CSGALNACT1,CTNND2,MACF1,MAML2,RORA,GLI3,ATP1A2,ITPR2
7.136e-04	-7.25	multicellular organismal process	biological process	GO:0032501	6177	28	18204	49	TNIK,CTNND2,PRKCA,SOX5,NTRK2,CTNNA2,DTNA,BMPR1B,PTPRZ1,MSI2,NEBL,GPM6A,ABLIM1,SLC1A3,RORA,NRG3,RYR3,CSGALNACT1,LSAMP,GLI3,ATP1A2,NTM,SLC4A4,CDH20,RFX4,PREX2,SLC1A2,NFIA
7.405e-04	-7.21	monoatomic ion transmembrane transporter activity	molecular function	GO:0015075	752	8	18094	48	ITPR2,TRPM3,ATP1A2,GPM6A,SLC1A2,SLC4A4,RYR3,SLC1A3
7.411e-04	-7.21	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma-transitional_cell_carcinoma	6040	29	16828	49	NFIA,GLI3,ATP1A2,ITPR2,GLIS3,RFX4,ZBTB20,NRG3,NEBL,SLC4A4,FMN2,MACF1,DPP10,ADCY2,CDH20,PARD3B,NTRK2,DST,SPARCL1,ABLIM1,SLC1A3,GPM6A,SORBS1,PREX2,TRPM3,MGAT4C,DTNA,PTPRZ1,GPC5
7.424e-04	-7.21	papillary_renal_cell_carcinoma	COSMIC cancer mutations	papillary_renal_cell_carcinoma	6364	30	16828	49	TRPM3,PREX2,NTM,GPC5,RYR3,PTPRZ1,PAMR1,NTRK2,ADCY2,TNIK,SOX5,ABLIM1,DST,PITPNC1,SLC4A4,NRG3,RFX4,ZBTB20,DPP10,BMPR1B,MACF1,CTNND2,FMN2,GLI3,PRKCA,MAML2,RORA,NFIA,ITPR2,ATP1A2
7.424e-04	-7.21	kidney-carcinoma-papillary_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-papillary_renal_cell_carcinoma	6364	30	16828	49	MACF1,CTNND2,BMPR1B,DPP10,FMN2,NRG3,ZBTB20,RFX4,SLC4A4,ITPR2,ATP1A2,PRKCA,GLI3,NFIA,MAML2,RORA,RYR3,PTPRZ1,PAMR1,GPC5,TRPM3,PREX2,NTM,TNIK,ABLIM1,SOX5,DST,PITPNC1,NTRK2,ADCY2
7.457e-04	-7.20	transitional_cell_carcinoma	COSMIC cancer mutations	transitional_cell_carcinoma	6042	29	16828	49	GLI3,NFIA,ITPR2,ATP1A2,NEBL,SLC4A4,ZBTB20,RFX4,GLIS3,NRG3,DPP10,MACF1,FMN2,NTRK2,CDH20,PARD3B,ADCY2,SLC1A3,ABLIM1,SPARCL1,DST,MGAT4C,DTNA,TRPM3,SORBS1,GPM6A,PREX2,GPC5,PTPRZ1
7.502e-04	-7.20	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-mast_cell_neoplasm	248	5	16828	49	GPC5,NPAS3,NFIA,ADCY2,NRG3
7.502e-04	-7.20	mast_cell_neoplasm	COSMIC cancer mutations	mast_cell_neoplasm	248	5	16828	49	NPAS3,GPC5,ADCY2,NRG3,NFIA
7.526e-04	-7.19	cellular response to endogenous stimulus	biological process	GO:0071495	1135	10	18204	49	SOX5,SLC1A2,NTRK2,ITPR2,ATP1A2,NFIA,SORBS1,BMPR1B,SLC1A3,RYR3
7.564e-04	-7.19	forebrain development	biological process	GO:0030900	408	6	18204	49	RFX4,NRG3,SLC1A2,ATP1A2,NTRK2,GLI3
7.686e-04	-7.17	adenoma	COSMIC cancer mutations	adenoma	2873	18	16828	49	SOX5,DST,NTRK2,CDH20,GLI3,PRKCA,ADCY2,GPC5,BMPR1B,MACF1,RYR3,PTPRZ1,CTNND2,NPAS3,TRPM3,NEBL,GPM6A,ZBTB20
7.941e-04	-7.14	plasma membrane protein complex	cellular component	GO:0098797	600	7	19108	49	CDH20,DPP10,BMPR1B,ATP1A2,CTNNA2,SORBS1,PRKCA
8.065e-04	-7.12	acute_myeloid_leukaemia	COSMIC cancer mutations	acute_myeloid_leukaemia	10418	41	16828	49	NFIA,RORA,MAML2,PRKCA,GLI3,ATP1A2,ITPR2,GLIS3,RFX4,NRG3,NEBL,SLC4A4,FMN2,CTNND2,CSGALNACT1,MACF1,DPP10,MSI2,ADCY2,PARD3B,CDH20,NTRK2,DST,SPARCL1,NHSL1,ABLIM1,SOX5,TNIK,SLC1A3,NTM,PREX2,TRPM3,NPAS3,SLC1A2,FBXL7,NKAIN3,PTPRZ1,PAMR1,RYR3,LSAMP,GPC5
8.065e-04	-7.12	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-haematopoietic_neoplasm-acute_myeloid_leukaemia	10418	41	16828	49	SLC4A4,NEBL,NRG3,GLIS3,RFX4,DPP10,MACF1,CTNND2,CSGALNACT1,FMN2,PRKCA,GLI3,RORA,MAML2,NFIA,ITPR2,ATP1A2,NPAS3,TRPM3,PREX2,NTM,GPC5,LSAMP,RYR3,PAMR1,PTPRZ1,NKAIN3,FBXL7,SLC1A2,NTRK2,PARD3B,CDH20,MSI2,ADCY2,SLC1A3,TNIK,SOX5,ABLIM1,NHSL1,SPARCL1,DST
8.077e-04	-7.12	sodium ion transmembrane transporter activity	molecular function	GO:0015081	158	4	18094	48	SLC1A3,ATP1A2,SLC1A2,SLC4A4
8.086e-04	-7.12	human chr3q13.31	chromosome location	human chr3q13.31	22	2	26134	50	ZBTB20,LSAMP
8.145e-04	-7.11	retina development in camera-type eye	biological process	GO:0060041	156	4	18204	49	GPM6A,NFIA,BMPR1B,NTRK2
8.309e-04	-7.09	PARD3 (par-3 family cell polarity regulator)	protein interactions	56288	287	5	19454	50	DTNA,PARD3B,DST,SORBS1,NTRK2
8.443e-04	-7.08	plasma membrane bounded cell projection organization	biological process	GO:0120036	1152	10	18204	49	GPM6A,RFX4,CTNND2,PTPRZ1,TNIK,CTNNA2,BMPR1B,GLI3,ABLIM1,PREX2
8.793e-04	-7.04	YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)	protein interactions	7532	1211	10	19454	50	NHSL1,FMN2,DST,PRKCA,TPD52L1,ABLIM1,PARD3B,MACF1,SORBS1,PITPNC1
8.898e-04	-7.02	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	7434	33	16828	49	ATP1A2,ITPR2,RORA,MAML2,GLI3,FMN2,MACF1,CSGALNACT1,CTNND2,TPD52L1,NRG3,ZBTB20,GLIS3,SLC4A4,NEBL,DST,SPARCL1,TNIK,SOX5,ABLIM1,SLC1A3,ADCY2,PARD3B,NTRK2,NKAIN3,RYR3,PTPRZ1,PAMR1,PREX2,SORBS1,NPAS3,TRPM3,DTNA
9.010e-04	-7.01	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-pharynx-carcinoma-squamous_cell_carcinoma	1485	12	16828	49	SORBS1,NRG3,PREX2,NPAS3,DTNA,FMN2,MACF1,RYR3,PTPRZ1,GPC5,PARD3B,DST
9.140e-04	-7.00	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-embryonal	2659	17	16828	49	NPAS3,TRPM3,SORBS1,PREX2,GLIS3,MACF1,RYR3,CTNND2,PTPRZ1,FMN2,GLI3,PARD3B,RORA,MAML2,NFIA,ADCY2,SPARCL1
9.140e-04	-7.00	embryonal	COSMIC cancer mutations	embryonal	2659	17	16828	49	GLI3,PARD3B,NFIA,ADCY2,RORA,MAML2,SPARCL1,TRPM3,NPAS3,GLIS3,SORBS1,PREX2,CTNND2,PTPRZ1,MACF1,RYR3,FMN2
9.825e-04	-6.93	signaling	biological process	GO:0023052	4968	24	18204	49	SORBS1,ADCY2,CTNND2,TNIK,DTNA,BMPR1B,PRKCA,FMN2,NTRK2,MACF1,NFIA,SPARCL1,SLC1A2,PREX2,DST,PITPNC1,RYR3,SLC1A3,NRG3,RORA,GLI3,MAML2,ATP1A2,ITPR2
9.890e-04	-6.92	head development	biological process	GO:0060322	774	8	18204	49	GLI3,SLC1A2,NTRK2,ATP1A2,CTNNA2,NRG3,RORA,RFX4
9.985e-04	-6.91	regulation of cartilage development	biological process	GO:0061035	73	3	18204	49	GLI3,SOX5,BMPR1B
1.022e-03	-6.89	Htt (huntingtin)	protein interactions	15194	77	3	19454	50	LSAMP,NTM,GPM6A
1.026e-03	-6.88	acidic amino acid transmembrane transporter activity	molecular function	GO:0015172	18	2	18094	48	SLC1A3,SLC1A2
1.026e-03	-6.88	intracellularly gated calcium channel activity	molecular function	GO:0015278	18	2	18094	48	ITPR2,RYR3
1.042e-03	-6.87	cellular component organization	biological process	GO:0016043	5636	26	18204	49	NFIA,SPARCL1,PREX2,SLC1A2,RFX4,MACF1,CDH20,GLI3,DST,RYR3,CSGALNACT1,PITPNC1,NRG3,PARD3B,SORBS1,ABLIM1,NEBL,GPM6A,PTPRZ1,CTNNA2,BMPR1B,PRKCA,FMN2,CTNND2,TNIK,TRPM3
1.043e-03	-6.87	synapse	cellular component	GO:0045202	1473	11	19108	49	SPARCL1,DTNA,SLC1A3,ATP1A2,NRG3,CTNND2,NTRK2,GPM6A,TNIK,PTPRZ1,SLC1A2
1.053e-03	-6.86	LCK (LCK proto-oncogene, Src family tyrosine kinase)	protein interactions	3932	455	6	19454	50	MACF1,CTNND2,PRKCA,DST,FMN2,DTNA
1.059e-03	-6.85	Oxytocin signaling pathway	KEGG pathways	ko04921	152	4	7161	22	ADCY2,PRKCA,RYR3,ITPR2
1.059e-03	-6.85	Oxytocin signaling pathway	KEGG pathways	hsa04921	152	4	7161	22	PRKCA,RYR3,ADCY2,ITPR2
1.065e-03	-6.84	GSK3A (glycogen synthase kinase 3 alpha)	protein interactions	2931	456	6	19454	50	NHSL1,TNIK,PRKCA,DST,GLI3,MACF1
1.090e-03	-6.82	EF-hand	gene3d domains	1.10.238.10	272	5	14470	42	DTNA,MACF1,DST,RYR3,SPARCL1
1.113e-03	-6.80	skin-arm-malignant_melanoma	COSMIC cancer mutations	skin-arm-malignant_melanoma	1308	11	16828	49	ATP1A2,PRKCA,PARD3B,MACF1,DPP10,NPAS3,TRPM3,SORBS1,NTM,ZBTB20,SLC4A4
1.118e-03	-6.80	cell communication	biological process	GO:0007154	5010	24	18204	49	DTNA,BMPR1B,PRKCA,FMN2,NTRK2,CTNND2,TNIK,ADCY2,SORBS1,GLI3,ITPR2,ATP1A2,MAML2,DST,PITPNC1,RYR3,SLC1A3,RORA,NRG3,NFIA,SPARCL1,SLC1A2,PREX2,MACF1
1.134e-03	-6.78	spleen	COSMIC cancer mutations	spleen	408	6	16828	49	PTPRZ1,TNIK,PARD3B,NTM,ADCY2,SORBS1
1.154e-03	-6.76	cell projection organization	biological process	GO:0030030	1200	10	18204	49	PREX2,ABLIM1,GLI3,BMPR1B,CTNNA2,TNIK,PTPRZ1,RFX4,CTNND2,GPM6A
1.165e-03	-6.76	lung-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-squamous_cell_carcinoma	14664	49	16828	49	NFIA,MAML2,PRKCA,ATP1A2,ITPR2,NEBL,CSGALNACT1,MACF1,BMPR1B,ADCY2,CDH20,NTRK2,PITPNC1,DST,SPARCL1,NHSL1,SOX5,TNIK,SLC1A3,NTM,GPM6A,PREX2,TRPM3,NPAS3,MGAT4C,SLC1A2,FBXL7,NKAIN3,PTPRZ1,LSAMP,RORA,GLI3,RFX4,GLIS3,ZBTB20,NRG3,TPD52L1,SLC4A4,FMN2,CTNND2,DPP10,MSI2,PARD3B,ABLIM1,SORBS1,DTNA,PAMR1,RYR3,GPC5
1.165e-03	-6.75	membrane protein complex	cellular component	GO:0098796	1261	10	19108	49	BMPR1B,CTNNA2,PRKCA,CDH20,RYR3,DPP10,SLC1A2,ATP1A2,SLC1A3,SORBS1
1.179e-03	-6.74	cartilage condensation	biological process	GO:0001502	19	2	18204	49	SOX5,BMPR1B
1.210e-03	-6.72	positive regulation of carbohydrate metabolic process	biological process	GO:0045913	78	3	18204	49	SLC4A4,ZBTB20,SORBS1
1.210e-03	-6.72	dicarboxylic acid transport	biological process	GO:0006835	78	3	18204	49	SLC1A2,NTRK2,SLC1A3
1.247e-03	-6.69	solute:sodium symporter activity	molecular function	GO:0015370	80	3	18094	48	SLC1A3,SLC1A2,SLC4A4
1.250e-03	-6.68	inorganic cation transmembrane transport	biological process	GO:0098662	618	7	18204	49	SLC4A4,ITPR2,ATP1A2,GPM6A,RYR3,SLC1A3,TRPM3
1.257e-03	-6.68	Bile secretion	KEGG pathways	hsa04976	71	3	7161	22	ADCY2,ATP1A2,SLC4A4
1.257e-03	-6.68	Bile secretion	KEGG pathways	ko04976	71	3	7161	22	ATP1A2,ADCY2,SLC4A4
1.261e-03	-6.68	behavior	biological process	GO:0007610	619	7	18204	49	SLC1A3,PTPRZ1,SLC1A2,PREX2,ATP1A2,NTRK2,GLI3
1.263e-03	-6.67	monoatomic ion transmembrane transport	biological process	GO:0034220	804	8	18204	49	TRPM3,SLC1A3,RYR3,GPM6A,ATP1A2,ITPR2,SLC1A2,SLC4A4
1.274e-03	-6.67	central nervous system neuron differentiation	biological process	GO:0021953	176	4	18204	49	BMPR1B,NTRK2,RORA,GLI3
1.284e-03	-6.66	arm	COSMIC cancer mutations	arm	1331	11	16828	49	MACF1,DPP10,SORBS1,NTM,ZBTB20,SLC4A4,NPAS3,TRPM3,ATP1A2,PARD3B,PRKCA
1.290e-03	-6.65	plasma membrane region	cellular component	GO:0098590	1278	10	19108	49	MACF1,SLC4A4,PARD3B,TNIK,SLC1A2,DST,SLC1A3,SORBS1,ATP1A2,GPM6A
1.307e-03	-6.64	aspartate transmembrane transport	biological process	GO:0015810	20	2	18204	49	SLC1A2,SLC1A3
1.314e-03	-6.63	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymph_node-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	748	8	16828	49	DPP10,SLC1A3,CTNND2,SOX5,ITPR2,NEBL,DTNA,NTRK2
1.318e-03	-6.63	TENM1 (teneurin transmembrane protein 1)	protein interactions	10178	21	2	19454	50	MACF1,SORBS1
1.318e-03	-6.63	ovary-carcinoma	COSMIC cancer mutations	ovary-carcinoma	933	9	16828	49	NTRK2,PRKCA,PREX2,BMPR1B,ITPR2,TNIK,MACF1,ATP1A2,DST
1.321e-03	-6.63	stomach-adenocarcinoma	COSMIC cancer mutations	stomach-adenocarcinoma	4101	22	16828	49	NRG3,RFX4,SLC4A4,NEBL,FMN2,MACF1,CTNND2,CSGALNACT1,RORA,GLI3,PRKCA,ATP1A2,ITPR2,PREX2,MGAT4C,SLC1A2,PAMR1,GPC5,PARD3B,CDH20,DST,ABLIM1
1.396e-03	-6.57	metal ion transport	biological process	GO:0030001	630	7	18204	49	RYR3,GPM6A,TRPM3,SLC1A3,SLC4A4,ATP1A2,ITPR2
1.443e-03	-6.54	positive regulation of purine nucleotide catabolic process	biological process	GO:0033123	21	2	18204	49	ZBTB20,SLC4A4
1.443e-03	-6.54	cell aggregation	biological process	GO:0098743	21	2	18204	49	BMPR1B,SOX5
1.443e-03	-6.54	positive regulation of nucleotide catabolic process	biological process	GO:0030813	21	2	18204	49	ZBTB20,SLC4A4
1.443e-03	-6.54	positive regulation of glycolytic process	biological process	GO:0045821	21	2	18204	49	ZBTB20,SLC4A4
1.471e-03	-6.52	regulation of carbohydrate metabolic process	biological process	GO:0006109	183	4	18204	49	RORA,SLC4A4,SORBS1,ZBTB20
1.474e-03	-6.52	monoatomic cation transmembrane transport	biological process	GO:0098655	636	7	18204	49	SLC4A4,ATP1A2,ITPR2,RYR3,GPM6A,TRPM3,SLC1A3
1.506e-03	-6.50	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	stomach-carcinoma-mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	9	16828	49	DPP10,GPC5,TRPM3,MACF1,GLI3,ITPR2,FMN2,SLC1A2,PREX2
1.506e-03	-6.50	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	COSMIC cancer mutations	mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	951	9	16828	49	FMN2,SLC1A2,DPP10,GPC5,ITPR2,MACF1,PREX2,TRPM3,GLI3
1.550e-03	-6.47	chondrocyte differentiation	biological process	GO:0002062	85	3	18204	49	SOX5,GLI3,BMPR1B
1.550e-03	-6.47	oligodendrocyte differentiation	biological process	GO:0048709	85	3	18204	49	NTRK2,GLI3,PTPRZ1
1.578e-03	-6.45	YWHAH (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta)	protein interactions	7533	1083	9	19454	50	PARD3B,MACF1,PITPNC1,SORBS1,NHSL1,FMN2,DST,ABLIM1,TPD52L1
1.584e-03	-6.45	intracellular sodium ion homeostasis	biological process	GO:0006883	22	2	18204	49	SLC1A3,ATP1A2
1.594e-03	-6.44	DEP_dom	interpro domains	IPR000591	22	2	18521	50	PREX2,FMN2
1.683e-03	-6.39	amino acid:sodium symporter activity	molecular function	GO:0005283	23	2	18094	48	SLC1A3,SLC1A2
1.704e-03	-6.37	Opioid Signalling	REACTOME pathways	R-HSA-111885	85	3	10285	29	ADCY2,PRKCA,ITPR2
1.712e-03	-6.37	SHC1 events in ERBB2 signaling	REACTOME pathways	R-HSA-1250196	22	2	10285	29	PRKCA,NRG3
1.715e-03	-6.37	human chr17q24.2	chromosome location	human chr17q24.2	32	2	26134	50	PRKCA,PITPNC1
1.743e-03	-6.35	Actinin_actin-bd_CS	interpro domains	IPR001589	23	2	18521	50	DST,MACF1
1.745e-03	-6.35	Calcium Regulation in the Cardiac Cell	WikiPathways	WP536	151	4	5310	19	ADCY2,RYR3,PRKCA,ITPR2
1.757e-03	-6.34	TIAM1 (TIAM Rac1 associated GEF 1)	protein interactions	7074	201	4	19454	50	RYR3,PRKCA,ATP1A2,DTNA
1.781e-03	-6.33	ovary-carcinoma-serous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-serous_carcinoma	10710	41	16828	49	FBXL7,SLC1A2,RYR3,PAMR1,PTPRZ1,GPC5,LSAMP,PREX2,SORBS1,NTM,NPAS3,TRPM3,DTNA,MGAT4C,DST,NHSL1,TNIK,SOX5,SLC1A3,ADCY2,MSI2,CDH20,PARD3B,NTRK2,FMN2,MACF1,CTNND2,CSGALNACT1,DPP10,BMPR1B,NRG3,GLIS3,ZBTB20,SLC4A4,NEBL,ATP1A2,ITPR2,RORA,MAML2,GLI3,PRKCA
1.792e-03	-6.32	gallbladder	COSMIC cancer mutations	gallbladder	2821	17	16828	49	PITPNC1,NHSL1,SPARCL1,TNIK,ITPR2,PREX2,NRG3,TPD52L1,SLC4A4,TRPM3,FMN2,NKAIN3,RYR3,MACF1,CTNND2,PTPRZ1,DPP10
1.792e-03	-6.32	biliary_tract-gallbladder-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-gallbladder-carcinoma-adenocarcinoma	2821	17	16828	49	SPARCL1,NHSL1,PITPNC1,ITPR2,TNIK,FMN2,NKAIN3,DPP10,CTNND2,PTPRZ1,MACF1,RYR3,SLC4A4,NRG3,TPD52L1,PREX2,TRPM3
1.817e-03	-6.31	WWC1 (WW and C2 domain containing 1)	protein interactions	23286	94	3	19454	50	ABLIM1,PRKCA,TNIK
1.898e-03	-6.27	Spectrin_repeat	interpro domains	IPR002017	24	2	18521	50	MACF1,DST
1.905e-03	-6.26	Aldosterone synthesis and secretion	KEGG pathways	hsa04925	82	3	7161	22	ITPR2,PRKCA,ADCY2
1.905e-03	-6.26	Aldosterone synthesis and secretion	KEGG pathways	ko04925	82	3	7161	22	ITPR2,ADCY2,PRKCA
1.911e-03	-6.26	cell-cell junction	cellular component	GO:0005911	513	6	19108	49	CDH20,SORBS1,PARD3B,ATP1A2,CTNNA2,CTNND2
1.911e-03	-6.26	cellular component organization or biogenesis	biological process	GO:0071840	5850	26	18204	49	SORBS1,PARD3B,ABLIM1,NEBL,GPM6A,PTPRZ1,CTNNA2,BMPR1B,PRKCA,FMN2,CTNND2,TNIK,TRPM3,NFIA,SPARCL1,PREX2,SLC1A2,RFX4,MACF1,CDH20,GLI3,DST,CSGALNACT1,RYR3,PITPNC1,NRG3
1.913e-03	-6.26	human chr9q21.12-q21.13	chromosome location	human chr9q21.12-q21.13	1	1	26134	50	TRPM3
1.913e-03	-6.26	human chr15q13.3-q14	chromosome location	human chr15q13.3-q14	1	1	26134	50	RYR3
1.913e-03	-6.26	human chr12q21.31-q21.32	chromosome location	human chr12q21.31-q21.32	1	1	26134	50	MGAT4C
1.913e-03	-6.26	human chr3q26.2-q26.31	chromosome location	human chr3q26.2-q26.31	1	1	26134	50	TNIK
1.960e-03	-6.23	synapse organization	biological process	GO:0050808	333	5	18204	49	SPARCL1,CTNND2,NFIA,GPM6A,NRG3
1.972e-03	-6.23	Spectrin	pfam domains	PF00435	24	2	17795	49	MACF1,DST
2.012e-03	-6.21	camera-type eye development	biological process	GO:0043010	335	5	18204	49	NFIA,GPM6A,BMPR1B,GLI3,NTRK2
2.019e-03	-6.21	striated_muscle	COSMIC cancer mutations	striated_muscle	4228	22	16828	49	GLIS3,DPP10,CTNND2,MACF1,FMN2,GLI3,RORA,MAML2,NFIA,TRPM3,NPAS3,SORBS1,PREX2,PTPRZ1,PAMR1,RYR3,PARD3B,CDH20,ADCY2,SLC1A3,SPARCL1,NHSL1
2.022e-03	-6.20	Calcium signaling pathway	KEGG pathways	ko04020	181	4	7161	22	ITPR2,RYR3,PRKCA,ADCY2
2.022e-03	-6.20	Calcium signaling pathway	KEGG pathways	hsa04020	181	4	7161	22	ITPR2,PRKCA,RYR3,ADCY2
2.039e-03	-6.20	Glutamate Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-210500	24	2	10285	29	SLC1A2,SLC1A3
2.047e-03	-6.19	L-glutamate transmembrane transport	biological process	GO:0015813	25	2	18204	49	SLC1A3,SLC1A2
2.061e-03	-6.18	ABI1 (abl interactor 1)	protein interactions	10006	210	4	19454	50	NHSL1,DST,SORBS1,SLC1A3
2.063e-03	-6.18	Myometrial Relaxation and Contraction Pathways	WikiPathways	WP289	158	4	5310	19	ITPR2,PRKCA,ADCY2,RYR3
2.112e-03	-6.16	Insulin secretion	KEGG pathways	hsa04911	85	3	7161	22	PRKCA,ADCY2,ATP1A2
2.152e-03	-6.14	extrinsic component of plasma membrane	cellular component	GO:0019897	100	3	19108	49	CTNNA2,DTNA,CDH20
2.178e-03	-6.13	CXADR (CXADR Ig-like cell adhesion molecule)	protein interactions	1525	357	5	19454	50	SORBS1,DST,MACF1,NEBL,TNIK
2.181e-03	-6.13	KCNJ12 (potassium inwardly rectifying channel subfamily J member 12)	protein interactions	3768	27	2	19454	50	ABLIM1,DTNA
2.192e-03	-6.12	Proximal tubule bicarbonate reclamation	KEGG pathways	ko04964	23	2	7161	22	SLC4A4,ATP1A2
2.192e-03	-6.12	Proximal tubule bicarbonate reclamation	KEGG pathways	hsa04964	23	2	7161	22	ATP1A2,SLC4A4
2.214e-03	-6.11	C4-dicarboxylate transport	biological process	GO:0015740	26	2	18204	49	SLC1A3,SLC1A2
2.217e-03	-6.11	YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)	protein interactions	7534	1138	9	19454	50	PARD3B,SORBS1,PITPNC1,MACF1,NHSL1,PRKCA,TPD52L1,ABLIM1,DST
2.227e-03	-6.11	calcium ion transmembrane transport	biological process	GO:0070588	205	4	18204	49	RYR3,GPM6A,TRPM3,ITPR2
2.259e-03	-6.09	Transmembrane transport of small molecules	REACTOME pathways	R-HSA-382551	677	7	10285	29	TRPM3,SLC1A2,SLC1A3,ADCY2,SLC4A4,RYR3,ATP1A2
2.261e-03	-6.09	skin-scalp-malignant_melanoma	COSMIC cancer mutations	skin-scalp-malignant_melanoma	634	7	16828	49	PTPRZ1,FMN2,NTM,SORBS1,PREX2,NFIA,NEBL
2.321e-03	-6.07	GFAP (glial fibrillary acidic protein)	protein interactions	2670	217	4	19454	50	NKAIN3,RORA,PRKCA,ABLIM1
2.322e-03	-6.07	adrenal_gland	COSMIC cancer mutations	adrenal_gland	2628	16	16828	49	GLI3,NTRK2,ADCY2,MAML2,SOX5,ATP1A2,NHSL1,TRPM3,NRG3,ZBTB20,RFX4,CTNND2,CSGALNACT1,PTPRZ1,SLC1A2,FMN2
2.332e-03	-6.06	Gap junction	KEGG pathways	hsa04540	88	3	7161	22	PRKCA,ADCY2,ITPR2
2.332e-03	-6.06	Gap junction	KEGG pathways	ko04540	88	3	7161	22	PRKCA,ADCY2,ITPR2
2.341e-03	-6.06	actin filament binding	molecular function	GO:0051015	211	4	18094	48	CTNNA2,NEBL,MACF1,ABLIM1
2.398e-03	-6.03	bone morphogenesis	biological process	GO:0060349	99	3	18204	49	GLI3,CSGALNACT1,BMPR1B
2.403e-03	-6.03	cell motility	biological process	GO:0048870	1101	9	18204	49	GPM6A,DST,GPC5,NRG3,CTNNA2,CDH20,GLI3,FMN2,NTRK2
2.412e-03	-6.03	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-spleen-lymphoid_neoplasm-marginal_zone_lymphoma	323	5	16828	49	SORBS1,ADCY2,NTM,PARD3B,PTPRZ1
2.419e-03	-6.02	Muscle contraction	REACTOME pathways	R-HSA-397014	204	4	10285	29	ATP1A2,ITPR2,SORBS1,RYR3
2.439e-03	-6.02	signal transduction	biological process	GO:0007165	4637	22	18204	49	ADCY2,SORBS1,CTNND2,TNIK,DTNA,BMPR1B,PRKCA,NTRK2,FMN2,MACF1,NFIA,SPARCL1,PREX2,DST,RYR3,PITPNC1,NRG3,RORA,GLI3,MAML2,ATP1A2,ITPR2
2.467e-03	-6.00	response to alkaloid	biological process	GO:0043279	100	3	18204	49	RYR3,SLC1A2,SLC1A3
2.545e-03	-5.97	ACTININ_2	prosite domains	PS00020	23	2	12186	40	MACF1,DST
2.545e-03	-5.97	ACTININ_1	prosite domains	PS00019	23	2	12186	40	MACF1,DST
2.564e-03	-5.97	H zone	cellular component	GO:0031673	1	1	19108	49	DST
2.570e-03	-5.96	fbxw7.L (F-box and WD repeat domain containing 7 L homeolog)	protein interactions	734230	1	1	19454	50	PRKCA
2.570e-03	-5.96	TAS2R20 (taste 2 receptor member 20)	protein interactions	259295	1	1	19454	50	PRKCA
2.570e-03	-5.96	EB1a (microtubule end binding protein EB1A)	protein interactions	823923	1	1	19454	50	DST
2.570e-03	-5.96	Bdnf (brain derived neurotrophic factor)	protein interactions	12064	1	1	19454	50	NTRK2
2.570e-03	-5.96	Lztr1 (leucine-zipper-like transcriptional regulator, 1)	protein interactions	66863	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Hipk3 (homeodomain interacting protein kinase 3)	protein interactions	15259	1	1	19454	50	GLIS3
2.570e-03	-5.96	Dcaf7 (DDB1 and CUL4 associated factor 7)	protein interactions	71833	1	1	19454	50	BMPR1B
2.570e-03	-5.96	1700006A11Rik (RIKEN cDNA 1700006A11 gene)	protein interactions	71824	1	1	19454	50	BMPR1B
2.570e-03	-5.96	Isl1 (ISL1 transcription factor, LIM/homeodomain)	protein interactions	16392	1	1	19454	50	GLIS3
2.570e-03	-5.96	Dynlt1 (dynein light chain Tctex-type 1)	protein interactions	83462	1	1	19454	50	NTRK2
2.570e-03	-5.96	mal3 (EB1 family Mal3)	protein interactions	2542123	1	1	19454	50	DST
2.570e-03	-5.96	Agtrap (angiotensin II, type I receptor-associated protein)	protein interactions	11610	1	1	19454	50	PITPNC1
2.603e-03	-5.95	MAPRE3 (microtubule associated protein RP/EB family member 3)	protein interactions	22924	224	4	19454	50	ABLIM1,DST,GPM6A,MACF1
2.648e-03	-5.93	GnRH signaling pathway	KEGG pathways	hsa04912	92	3	7161	22	PRKCA,ADCY2,ITPR2
2.648e-03	-5.93	GnRH signaling pathway	KEGG pathways	ko04912	92	3	7161	22	ITPR2,ADCY2,PRKCA
2.653e-03	-5.93	peptidoglycan glycosyltransferase activity	molecular function	GO:0008955	1	1	18094	48	CSGALNACT1
2.653e-03	-5.93	brain-derived neurotrophic factor receptor activity	molecular function	GO:0060175	1	1	18094	48	NTRK2
2.673e-03	-5.92	ligand-gated calcium channel activity	molecular function	GO:0099604	29	2	18094	48	ITPR2,RYR3
2.673e-03	-5.92	amino acid:monoatomic cation symporter activity	molecular function	GO:0005416	29	2	18094	48	SLC1A3,SLC1A2
2.681e-03	-5.92	marginal_zone_lymphoma	COSMIC cancer mutations	marginal_zone_lymphoma	331	5	16828	49	PARD3B,PTPRZ1,SORBS1,ADCY2,NTM
2.692e-03	-5.92	olfactory cortex development	biological process	GO:0021989	1	1	18204	49	ATP1A2
2.692e-03	-5.92	homologous chromosome movement towards spindle pole in meiosis I anaphase	biological process	GO:0051758	1	1	18204	49	FMN2
2.692e-03	-5.92	sagittal suture morphogenesis	biological process	GO:0060367	1	1	18204	49	GLI3
2.692e-03	-5.92	positive regulation of angiotensin-activated signaling pathway	biological process	GO:0110063	1	1	18204	49	PRKCA
2.692e-03	-5.92	negative regulation of calcium:sodium antiporter activity	biological process	GO:1903280	1	1	18204	49	ATP1A2
2.692e-03	-5.92	lambdoid suture morphogenesis	biological process	GO:0060366	1	1	18204	49	GLI3
2.692e-03	-5.92	directional guidance of interneurons involved in migration from the subpallium to the cortex	biological process	GO:0021840	1	1	18204	49	NRG3
2.692e-03	-5.92	chemorepulsion involved in interneuron migration from the subpallium to the cortex	biological process	GO:0021842	1	1	18204	49	NRG3
2.692e-03	-5.92	trans-synaptic signaling by neuropeptide, modulating synaptic transmission	biological process	GO:0099551	1	1	18204	49	NTRK2
2.692e-03	-5.92	lateral semicircular canal development	biological process	GO:0060875	1	1	18204	49	GLI3
2.692e-03	-5.92	trans-synaptic signaling by neuropeptide	biological process	GO:0099540	1	1	18204	49	NTRK2
2.692e-03	-5.92	lateral ganglionic eminence cell proliferation	biological process	GO:0022018	1	1	18204	49	GLI3
2.692e-03	-5.92	anterior semicircular canal development	biological process	GO:0060873	1	1	18204	49	GLI3
2.692e-03	-5.92	subpallium cell proliferation in forebrain	biological process	GO:0022012	1	1	18204	49	GLI3
2.700e-03	-5.91	MAML2_TAD	interpro domains	IPR048452	1	1	18521	50	MAML2
2.700e-03	-5.91	Nebulette_SH3	interpro domains	IPR035631	1	1	18521	50	NEBL
2.700e-03	-5.91	NTRK2	interpro domains	IPR020455	1	1	18521	50	NTRK2
2.700e-03	-5.91	cPKC_alpha	interpro domains	IPR034663	1	1	18521	50	PRKCA
2.700e-03	-5.91	SORBS1_SH3_2	interpro domains	IPR035611	1	1	18521	50	SORBS1
2.700e-03	-5.91	SORBS1_SH3_1	interpro domains	IPR035610	1	1	18521	50	SORBS1
2.700e-03	-5.91	SPARC-like_p1	interpro domains	IPR016359	1	1	18521	50	SPARCL1
2.700e-03	-5.91	Rex2_DEP_1	interpro domains	IPR037367	1	1	18521	50	PREX2
2.700e-03	-5.91	SORBS1_SH3	interpro domains	IPR035606	1	1	18521	50	SORBS1
2.709e-03	-5.91	large_intestine-caecum-carcinoma-adenocarcinoma	COSMIC cancer mutations	large_intestine-caecum-carcinoma-adenocarcinoma	14236	48	16828	49	BMPR1B,MACF1,CSGALNACT1,NEBL,ATP1A2,ITPR2,MAML2,NFIA,PRKCA,NKAIN3,FBXL7,SLC1A2,LSAMP,PTPRZ1,PREX2,GPM6A,NTM,MGAT4C,NPAS3,TRPM3,NHSL1,SPARCL1,DST,PITPNC1,SLC1A3,TNIK,SOX5,ADCY2,NTRK2,CDH20,FMN2,DPP10,CTNND2,SLC4A4,NRG3,TPD52L1,GLIS3,ZBTB20,RFX4,RORA,GLI3,GPC5,RYR3,PAMR1,SORBS1,DTNA,ABLIM1,PARD3B
2.754e-03	-5.89	MAML2_TAD	pfam domains	PF20804	1	1	17795	49	MAML2
2.773e-03	-5.89	Calmodulin induced events	REACTOME pathways	R-HSA-111933	28	2	10285	29	PRKCA,ADCY2
2.773e-03	-5.89	CaM pathway	REACTOME pathways	R-HSA-111997	28	2	10285	29	PRKCA,ADCY2
2.809e-03	-5.87	caecum	COSMIC cancer mutations	caecum	14248	48	16828	49	NKAIN3,FBXL7,SLC1A2,LSAMP,PTPRZ1,GPM6A,PREX2,NTM,MGAT4C,NPAS3,TRPM3,NHSL1,SPARCL1,DST,PITPNC1,SLC1A3,TNIK,SOX5,ADCY2,NTRK2,CDH20,BMPR1B,MACF1,CSGALNACT1,NEBL,ATP1A2,ITPR2,MAML2,NFIA,PRKCA,GPC5,RYR3,PAMR1,SORBS1,DTNA,ABLIM1,PARD3B,FMN2,DPP10,CTNND2,SLC4A4,TPD52L1,NRG3,RFX4,ZBTB20,GLIS3,RORA,GLI3
2.815e-03	-5.87	EF_hand_dom	interpro domains	IPR002048	218	4	18521	50	RYR3,DST,MACF1,SPARCL1
2.827e-03	-5.87	glial cell differentiation	biological process	GO:0010001	219	4	18204	49	GLI3,PTPRZ1,NTRK2,NFIA
2.857e-03	-5.86	cell body	cellular component	GO:0044297	556	6	19108	49	SLC1A3,ATP1A2,CTNND2,GPM6A,SLC1A2,BMPR1B
2.857e-03	-5.86	catenin complex	cellular component	GO:0016342	31	2	19108	49	CDH20,CTNNA2
2.859e-03	-5.86	inorganic ion transmembrane transport	biological process	GO:0098660	715	7	18204	49	SLC4A4,ITPR2,ATP1A2,RYR3,GPM6A,TRPM3,SLC1A3
2.870e-03	-5.85	AVPR1B (arginine vasopressin receptor 1B)	protein interactions	553	31	2	19454	50	PRKCA,FMN2
2.942e-03	-5.83	L-glutamate import	biological process	GO:0051938	30	2	18204	49	SLC1A3,SLC1A2
2.961e-03	-5.82	Spectrin/alpha-actinin	interpro domains	IPR018159	30	2	18521	50	MACF1,DST
2.964e-03	-5.82	cell migration	biological process	GO:0016477	921	8	18204	49	GLI3,FMN2,NTRK2,CTNNA2,CDH20,NRG3,GPM6A,GPC5
2.989e-03	-5.81	Circadian entrainment	KEGG pathways	ko04713	96	3	7161	22	RYR3,PRKCA,ADCY2
2.989e-03	-5.81	Circadian entrainment	KEGG pathways	hsa04713	96	3	7161	22	ADCY2,RYR3,PRKCA
2.993e-03	-5.81	YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta)	protein interactions	7529	965	8	19454	50	DST,TPD52L1,ABLIM1,NHSL1,MACF1,PITPNC1,SORBS1,PARD3B
3.005e-03	-5.81	SH3_domain	interpro domains	IPR001452	222	4	18521	50	NEBL,SORBS1,DST,MACF1
3.026e-03	-5.80	Transmission across Chemical Synapses	REACTOME pathways	R-HSA-112315	217	4	10285	29	PRKCA,ADCY2,SLC1A3,SLC1A2
3.051e-03	-5.79	intracellularly ligand-gated monoatomic ion channel activity	molecular function	GO:0005217	31	2	18094	48	ITPR2,RYR3
3.078e-03	-5.78	Inflammatory mediator regulation of TRP channels	KEGG pathways	ko04750	97	3	7161	22	ADCY2,PRKCA,ITPR2
3.078e-03	-5.78	Inflammatory mediator regulation of TRP channels	KEGG pathways	hsa04750	97	3	7161	22	ADCY2,PRKCA,ITPR2
3.132e-03	-5.77	acute_lymphoblastic_leukaemia	COSMIC cancer mutations	acute_lymphoblastic_leukaemia	2197	14	16828	49	SLC4A4,PREX2,DTNA,BMPR1B,PTPRZ1,NFIA,ADCY2,NTRK2,GLI3,PRKCA,PARD3B,ATP1A2,TNIK,SOX5
3.179e-03	-5.75	Ion_trans_dom	interpro domains	IPR005821	109	3	18521	50	RYR3,ITPR2,TRPM3
3.180e-03	-5.75	Ca-dependent events	REACTOME pathways	R-HSA-111996	30	2	10285	29	PRKCA,ADCY2
3.224e-03	-5.74	human chr11p13	chromosome location	human chr11p13	44	2	26134	50	PAMR1,SLC1A2
3.266e-03	-5.72	skeletal system morphogenesis	biological process	GO:0048705	228	4	18204	49	SOX5,GLI3,CSGALNACT1,BMPR1B
3.286e-03	-5.72	Transport of inorganic cations/anions and amino acids/oligopeptides	REACTOME pathways	R-HSA-425393	107	3	10285	29	SLC1A3,SLC1A2,SLC4A4
3.289e-03	-5.72	diffuse_adenocarcinoma	COSMIC cancer mutations	diffuse_adenocarcinoma	4383	22	16828	49	MACF1,CTNND2,DPP10,FMN2,NRG3,GLIS3,RFX4,ATP1A2,GLI3,RYR3,PTPRZ1,TRPM3,DTNA,MGAT4C,PREX2,GPM6A,ABLIM1,SOX5,SLC1A3,DST,NHSL1,ADCY2
3.289e-03	-5.72	stomach-carcinoma-diffuse_adenocarcinoma	COSMIC cancer mutations	stomach-carcinoma-diffuse_adenocarcinoma	4383	22	16828	49	SLC1A3,ABLIM1,SOX5,NHSL1,ATP1A2,DST,GLI3,ADCY2,DPP10,MACF1,RYR3,CTNND2,PTPRZ1,FMN2,DTNA,MGAT4C,TRPM3,NRG3,PREX2,GPM6A,GLIS3,RFX4
3.336e-03	-5.70	GJA1 (gap junction protein alpha 1)	protein interactions	2697	572	6	19454	50	TNIK,DTNA,PRKCA,MACF1,ITPR2,DST
3.344e-03	-5.70	transepithelial transport	biological process	GO:0070633	32	2	18204	49	SLC1A3,SLC1A2
3.344e-03	-5.70	positive regulation of ATP metabolic process	biological process	GO:1903580	32	2	18204	49	ZBTB20,SLC4A4
3.356e-03	-5.70	Ion_trans	pfam domains	PF00520	109	3	17795	49	RYR3,TRPM3,ITPR2
3.452e-03	-5.67	Retrograde endocannabinoid signaling	KEGG pathways	hsa04723	101	3	7161	22	ITPR2,ADCY2,PRKCA
3.452e-03	-5.67	Retrograde endocannabinoid signaling	KEGG pathways	ko04723	101	3	7161	22	ADCY2,PRKCA,ITPR2
3.486e-03	-5.66	dendrite development	biological process	GO:0016358	113	3	18204	49	CTNND2,CTNNA2,PREX2
3.497e-03	-5.66	acinar_carcinoma	COSMIC cancer mutations	acinar_carcinoma	1978	13	16828	49	NHSL1,ATP1A2,SOX5,GLI3,PARD3B,FMN2,CSGALNACT1,PTPRZ1,CTNND2,BMPR1B,DPP10,ZBTB20,TRPM3
3.497e-03	-5.66	pancreas-carcinoma-acinar_carcinoma	COSMIC cancer mutations	pancreas-carcinoma-acinar_carcinoma	1978	13	16828	49	ATP1A2,NHSL1,SOX5,PARD3B,GLI3,FMN2,DPP10,BMPR1B,CTNND2,CSGALNACT1,PTPRZ1,ZBTB20,TRPM3
3.504e-03	-5.65	eye development	biological process	GO:0001654	381	5	18204	49	BMPR1B,NFIA,GPM6A,NTRK2,GLI3
3.553e-03	-5.64	response to auditory stimulus	biological process	GO:0010996	33	2	18204	49	ATP1A2,SLC1A3
3.602e-03	-5.63	DELLA	smart domains	SM01129	1	1	9717	35	MACF1
3.621e-03	-5.62	serous_carcinoma	COSMIC cancer mutations	serous_carcinoma	10987	41	16828	49	CDH20,PARD3B,NTRK2,MSI2,ADCY2,SOX5,TNIK,SLC1A3,DST,NHSL1,TRPM3,NPAS3,MGAT4C,DTNA,NTM,SORBS1,PREX2,PTPRZ1,PAMR1,RYR3,LSAMP,GPC5,SLC1A2,FBXL7,GLI3,PRKCA,MAML2,RORA,ITPR2,ATP1A2,GLIS3,ZBTB20,NRG3,NEBL,SLC4A4,CTNND2,CSGALNACT1,MACF1,DPP10,BMPR1B,FMN2
3.635e-03	-5.62	NTKRECEPTOR2	prints domains	PR01941	1	1	5227	19	NTRK2
3.644e-03	-5.61	Integration of energy metabolism	REACTOME pathways	R-HSA-163685	111	3	10285	29	PRKCA,ADCY2,ITPR2
3.649e-03	-5.61	TPRA1 (transmembrane protein adipocyte associated 1)	protein interactions	131601	35	2	19454	50	ITPR2,BMPR1B
3.653e-03	-5.61	response to endogenous stimulus	biological process	GO:0009719	1402	10	18204	49	SLC1A3,RYR3,SOX5,SLC1A2,ATP1A2,ITPR2,NTRK2,NFIA,SORBS1,BMPR1B
3.663e-03	-5.61	visual system development	biological process	GO:0150063	385	5	18204	49	GPM6A,NFIA,BMPR1B,GLI3,NTRK2
3.688e-03	-5.60	solute:monoatomic cation symporter activity	molecular function	GO:0015294	117	3	18094	48	SLC1A2,SLC4A4,SLC1A3
3.815e-03	-5.57	metal ion binding	molecular function	GO:0046872	4239	20	18094	48	SLC1A3,PRKCA,RYR3,ITPR2,ZBTB20,MGAT4C,GLIS3,GLI3,PAMR1,SPARCL1,DST,ADCY2,SLC1A2,ATP1A2,DTNA,BMPR1B,MACF1,CSGALNACT1,RORA,ABLIM1
3.878e-03	-5.55	organic acid:sodium symporter activity	molecular function	GO:0005343	35	2	18094	48	SLC1A3,SLC1A2
3.885e-03	-5.55	SH3 Domains	gene3d domains	2.30.30.40	223	4	14470	42	NEBL,SORBS1,MACF1,DST
3.912e-03	-5.54	sensory system development	biological process	GO:0048880	391	5	18204	49	BMPR1B,GPM6A,NFIA,NTRK2,GLI3
3.916e-03	-5.54	monoatomic ion transport	biological process	GO:0006811	964	8	18204	49	ITPR2,ATP1A2,SLC1A2,SLC4A4,TRPM3,SLC1A3,RYR3,GPM6A
3.936e-03	-5.54	rhabdomyosarcoma	COSMIC cancer mutations	rhabdomyosarcoma	4150	21	16828	49	CTNND2,PAMR1,PTPRZ1,MACF1,RYR3,FMN2,TRPM3,NPAS3,GLIS3,PREX2,SORBS1,SLC1A3,SPARCL1,NHSL1,CDH20,PARD3B,GLI3,NFIA,ADCY2,RORA,MAML2
3.969e-03	-5.53	NCK2 (NCK adaptor protein 2)	protein interactions	8440	252	4	19454	50	NTRK2,SORBS1,NHSL1,TNIK
3.979e-03	-5.53	glutamatergic synapse	cellular component	GO:0098978	412	5	19108	49	SPARCL1,GPM6A,TNIK,NRG3,SLC1A2
3.990e-03	-5.52	neuron fate specification	biological process	GO:0048665	35	2	18204	49	GLI3,NFIA
4.003e-03	-5.52	adrenal_cortical_carcinoma	COSMIC cancer mutations	adrenal_cortical_carcinoma	2256	14	16828	49	RFX4,ZBTB20,NRG3,TRPM3,FMN2,SLC1A2,CTNND2,PTPRZ1,MAML2,NTRK2,GLI3,ATP1A2,NHSL1,SOX5
4.071e-03	-5.50	PADI3 (peptidyl arginine deiminase 3)	protein interactions	51702	37	2	19454	50	CSGALNACT1,SPARCL1
4.094e-03	-5.50	transporter activity	molecular function	GO:0005215	1211	9	18094	48	SLC4A4,SLC1A2,GPM6A,ATP1A2,SLC1A3,RYR3,PITPNC1,TRPM3,ITPR2
4.127e-03	-5.49	striated muscle contraction	biological process	GO:0006941	120	3	18204	49	DTNA,RYR3,ATP1A2
4.138e-03	-5.49	NGF signalling via TRKA from the plasma membrane	REACTOME pathways	R-HSA-187037	387	5	10285	29	NTRK2,NRG3,ITPR2,ADCY2,PRKCA
4.183e-03	-5.48	monoatomic cation transport	biological process	GO:0006812	766	7	18204	49	ATP1A2,ITPR2,SLC4A4,SLC1A3,TRPM3,GPM6A,RYR3
4.281e-03	-5.45	positive regulation of neurogenesis	biological process	GO:0050769	246	4	18204	49	MACF1,NTRK2,GLI3,PTPRZ1
4.289e-03	-5.45	superficial_spreading	COSMIC cancer mutations	superficial_spreading	1110	9	16828	49	MGAT4C,GLI3,SLC4A4,NTM,SORBS1,PREX2,ADCY2,CTNND2,MACF1
4.335e-03	-5.44	kidney-other-neoplasm	COSMIC cancer mutations	kidney-other-neoplasm	10653	40	16828	49	RFX4,ZBTB20,TPD52L1,NRG3,NEBL,FMN2,CTNND2,CSGALNACT1,MACF1,RORA,MAML2,GLI3,PRKCA,ATP1A2,ITPR2,GPM6A,PREX2,SORBS1,TRPM3,NPAS3,MGAT4C,DTNA,SLC1A2,FBXL7,NKAIN3,PTPRZ1,PAMR1,RYR3,LSAMP,GPC5,ADCY2,CDH20,NTRK2,DST,SPARCL1,NHSL1,SOX5,ABLIM1,TNIK,SLC1A3
4.432e-03	-5.42	chondroitin biosynthesis	BIOCYC pathways	HUMAN_PWY-6566	2	1	902	2	CSGALNACT1
4.448e-03	-5.42	Lima1 (LIM domain and actin binding 1)	protein interactions	65970	129	3	19454	50	ZBTB20,ABLIM1,ITPR2
4.451e-03	-5.41	positive regulation of purine nucleotide metabolic process	biological process	GO:1900544	37	2	18204	49	SLC4A4,ZBTB20
4.451e-03	-5.41	positive regulation of nucleotide metabolic process	biological process	GO:0045981	37	2	18204	49	SLC4A4,ZBTB20
4.451e-03	-5.41	positive regulation of glucose import	biological process	GO:0046326	37	2	18204	49	SORBS1,SLC1A2
4.470e-03	-5.41	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	COSMIC cancer mutations	central_nervous_system-brain-primitive_neuroectodermal_tumour-medulloblastoma-large_cell	1117	9	16828	49	ADCY2,NRG3,CDH20,SLC1A2,DST,FMN2,SOX5,RYR3,GPC5
4.494e-03	-5.41	DIRAS3 (DIRAS family GTPase 3)	protein interactions	9077	261	4	19454	50	MACF1,DST,DTNA,FMN2
4.506e-03	-5.40	cellular component assembly	biological process	GO:0022607	2472	14	18204	49	NEBL,GPM6A,RFX4,ABLIM1,SLC1A2,SORBS1,NRG3,TNIK,TRPM3,DST,RYR3,PRKCA,FMN2,CDH20
4.512e-03	-5.40	Z disc	cellular component	GO:0030018	130	3	19108	49	NEBL,DST,RYR3
4.543e-03	-5.39	animal organ morphogenesis	biological process	GO:0009887	988	8	18204	49	CSGALNACT1,NRG3,BMPR1B,CTNNA2,NTRK2,GLI3,SOX5,ABLIM1
4.597e-03	-5.38	calcium ion transport	biological process	GO:0006816	251	4	18204	49	RYR3,GPM6A,ITPR2,TRPM3
4.606e-03	-5.38	-	gene3d domains	1.20.58.60	35	2	14470	42	DST,MACF1
4.619e-03	-5.38	Cholinergic synapse	KEGG pathways	hsa04725	112	3	7161	22	PRKCA,ADCY2,ITPR2
4.676e-03	-5.37	functioning	COSMIC cancer mutations	functioning	1803	12	16828	49	SLC1A2,FMN2,PTPRZ1,NRG3,ZBTB20,RFX4,TRPM3,NHSL1,SOX5,MAML2,GLI3,NTRK2
4.676e-03	-5.37	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	COSMIC cancer mutations	adrenal_gland-adrenal_gland-adrenal_cortical_carcinoma-functioning	1803	12	16828	49	GLI3,NTRK2,MAML2,SOX5,NHSL1,TRPM3,ZBTB20,RFX4,NRG3,PTPRZ1,SLC1A2,FMN2
4.691e-03	-5.36	amino acid import across plasma membrane	biological process	GO:0089718	38	2	18204	49	SLC1A3,SLC1A2
4.814e-03	-5.34	SPEC	smart domains	SM00150	29	2	9717	35	DST,MACF1
4.852e-03	-5.33	cellular process	biological process	GO:0009987	14996	47	18204	49	MSI2,PARD3B,GPC5,TRPM3,NHSL1,ZBTB20,BMPR1B,SOX5,PRKCA,FMN2,RFX4,SLC1A2,PREX2,DST,RYR3,MGAT4C,NRG3,CDH20,LSAMP,GLI3,NTM,ATP1A2,GPM6A,NEBL,PTPRZ1,TPD52L1,GLIS3,SORBS1,ADCY2,ABLIM1,FBXL7,CTNND2,TNIK,CTNNA2,DTNA,DPP10,NTRK2,MACF1,NFIA,SPARCL1,PITPNC1,CSGALNACT1,SLC1A3,RORA,SLC4A4,MAML2,ITPR2
4.868e-03	-5.33	dendrite	cellular component	GO:0030425	620	6	19108	49	NTRK2,BMPR1B,ATP1A2,CTNND2,GPM6A,ADCY2
4.918e-03	-5.31	cell differentiation	biological process	GO:0030154	3645	18	18204	49	NTRK2,FMN2,NTM,GLI3,SOX5,BMPR1B,CTNNA2,NHSL1,RORA,TNIK,SLC1A3,CTNND2,PREX2,NFIA,MSI2,PTPRZ1,NEBL,GPM6A
4.936e-03	-5.31	sodium ion homeostasis	biological process	GO:0055078	39	2	18204	49	ATP1A2,SLC1A3
4.944e-03	-5.31	dendritic tree	cellular component	GO:0097447	622	6	19108	49	ADCY2,ATP1A2,CTNND2,GPM6A,BMPR1B,NTRK2
4.963e-03	-5.31	cellular developmental process	biological process	GO:0048869	3648	18	18204	49	GPM6A,NEBL,PTPRZ1,MSI2,NFIA,PREX2,CTNND2,SLC1A3,RORA,NHSL1,TNIK,CTNNA2,BMPR1B,GLI3,SOX5,NTM,FMN2,NTRK2
5.049e-03	-5.29	Myo1c (myosin IC)	protein interactions	17913	135	3	19454	50	ABLIM1,ITPR2,DST
5.090e-03	-5.28	cation binding	molecular function	GO:0043169	4341	20	18094	48	RYR3,PRKCA,SLC1A3,PAMR1,GLI3,GLIS3,ZBTB20,MGAT4C,ITPR2,CSGALNACT1,BMPR1B,MACF1,ATP1A2,DTNA,ADCY2,SLC1A2,DST,SPARCL1,RORA,ABLIM1
5.127e-03	-5.27	RHOB (ras homolog family member B)	protein interactions	388	832	7	19454	50	DTNA,FMN2,ABLIM1,TNIK,PARD3B,MACF1,SLC1A3
5.131e-03	-5.27	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	120	3	16828	49	CTNND2,DST,FMN2
5.134e-03	-5.27	Zmym2 (zinc finger, MYM-type 2)	protein interactions	76007	2	1	19454	50	GLIS3
5.134e-03	-5.27	Bcr (BCR activator of RhoGEF and GTPase)	protein interactions	110279	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Grin2c (glutamate ionotropic receptor NMDA type subunit 2C)	protein interactions	24411	2	1	19454	50	PRKCA
5.134e-03	-5.27	Klhl1 (kelch-like 1)	protein interactions	93688	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Irf7 (interferon regulatory factor 7)	protein interactions	54123	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Sh3kbp1 (SH3-domain kinase binding protein 1)	protein interactions	58194	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Ppp3cc (protein phosphatase 3, catalytic subunit, gamma isoform)	protein interactions	19057	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Kdm4c (lysine (K)-specific demethylase 4C)	protein interactions	76804	2	1	19454	50	GLIS3
5.134e-03	-5.27	Fbxo34 (F-box protein 34)	protein interactions	78938	2	1	19454	50	BMPR1B
5.134e-03	-5.27	numb (numb)	protein interactions	34263	2	1	19454	50	PRKCA
5.134e-03	-5.27	Fkbp1a (FK506 binding protein 1a)	protein interactions	14225	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Fkbp1b (FK506 binding protein 1b)	protein interactions	14226	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Bmpr2 (bone morphogenetic protein receptor type 2)	protein interactions	12168	2	1	19454	50	BMPR1B
5.134e-03	-5.27	Mknk2 (MAP kinase-interacting serine/threonine kinase 2)	protein interactions	17347	2	1	19454	50	BMPR1B
5.187e-03	-5.26	cyclic purine nucleotide metabolic process	biological process	GO:0052652	40	2	18204	49	ADCY2,RORA
5.198e-03	-5.26	RDX (radixin)	protein interactions	5962	272	4	19454	50	NEBL,MACF1,DST,ABLIM1
5.220e-03	-5.26	GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)	protein interactions	2891	42	2	19454	50	PRKCA,GPM6A
5.238e-03	-5.25	EF_HAND_2	prosite domains	PS50222	215	4	12186	40	RYR3,SPARCL1,DST,MACF1
5.299e-03	-5.24	histone H3T6 kinase activity	molecular function	GO:0035403	2	1	18094	48	PRKCA
5.299e-03	-5.24	calcium,diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004698	2	1	18094	48	PRKCA
5.302e-03	-5.24	lung-left_upper_lobe-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-left_upper_lobe-carcinoma-adenocarcinoma	556	6	16828	49	FBXL7,RYR3,CTNND2,SLC4A4,ADCY2,NTRK2
5.312e-03	-5.24	SYNE3 (spectrin repeat containing nuclear envelope family member 3)	protein interactions	161176	440	5	19454	50	SORBS1,ABLIM1,MACF1,GLI3,DST
5.376e-03	-5.23	UDP-glucuronate metabolic process	biological process	GO:0046398	2	1	18204	49	CSGALNACT1
5.376e-03	-5.23	mammary gland specification	biological process	GO:0060594	2	1	18204	49	GLI3
5.376e-03	-5.23	positive regulation of dense core granule biogenesis	biological process	GO:2000707	2	1	18204	49	PRKCA
5.376e-03	-5.23	larynx development	biological process	GO:0120224	2	1	18204	49	GLI3
5.376e-03	-5.23	smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	biological process	GO:0021776	2	1	18204	49	GLI3
5.376e-03	-5.23	larynx morphogenesis	biological process	GO:0120223	2	1	18204	49	GLI3
5.376e-03	-5.23	chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	biological process	GO:0050653	2	1	18204	49	CSGALNACT1
5.377e-03	-5.23	somatodendritic compartment	cellular component	GO:0036477	842	7	19108	49	SLC1A3,GPM6A,ATP1A2,ADCY2,CTNND2,BMPR1B,NTRK2
5.383e-03	-5.22	amino acid transport	biological process	GO:0006865	132	3	18204	49	SLC1A2,NTRK2,SLC1A3
5.392e-03	-5.22	Distrobrevin	interpro domains	IPR017432	2	1	18521	50	DTNA
5.392e-03	-5.22	Osteonectin_CS	interpro domains	IPR001999	2	1	18521	50	SPARCL1
5.392e-03	-5.22	Formin_Cappuccino_subfam	interpro domains	IPR001265	2	1	18521	50	FMN2
5.392e-03	-5.22	MSI_RRM2	interpro domains	IPR034126	2	1	18521	50	MSI2
5.392e-03	-5.22	Par3/HAL_N	interpro domains	IPR021922	2	1	18521	50	PARD3B
5.392e-03	-5.22	Alpha_CARP_receptor-type	interpro domains	IPR041887	2	1	18521	50	PTPRZ1
5.394e-03	-5.22	left_upper_lobe	COSMIC cancer mutations	left_upper_lobe	558	6	16828	49	CTNND2,RYR3,FBXL7,NTRK2,SLC4A4,ADCY2
5.422e-03	-5.22	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-acute_lymphoblastic_leukaemia	2081	13	16828	49	ATP1A2,SOX5,TNIK,NFIA,ADCY2,NTRK2,GLI3,PRKCA,BMPR1B,PTPRZ1,SLC4A4,PREX2,DTNA
5.432e-03	-5.22	Ig_I-set	interpro domains	IPR013098	132	3	18521	50	NTM,LSAMP,NTRK2
5.440e-03	-5.21	sarcoplasmic reticulum membrane	cellular component	GO:0033017	43	2	19108	49	ITPR2,RYR3
5.443e-03	-5.21	cyclic nucleotide metabolic process	biological process	GO:0009187	41	2	18204	49	ADCY2,RORA
5.443e-03	-5.21	cell-substrate junction assembly	biological process	GO:0007044	41	2	18204	49	SORBS1,DST
5.462e-03	-5.21	lung-carcinoma-adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-adenocarcinoma	15133	49	16828	49	SORBS1,DTNA,PAMR1,RYR3,GPC5,MSI2,PARD3B,ABLIM1,GLIS3,RFX4,ZBTB20,TPD52L1,NRG3,SLC4A4,FMN2,CTNND2,DPP10,RORA,GLI3,NTM,GPM6A,PREX2,TRPM3,NPAS3,MGAT4C,SLC1A2,FBXL7,NKAIN3,PTPRZ1,LSAMP,ADCY2,CDH20,NTRK2,PITPNC1,DST,SPARCL1,NHSL1,SOX5,TNIK,SLC1A3,NEBL,CSGALNACT1,MACF1,BMPR1B,NFIA,MAML2,PRKCA,ATP1A2,ITPR2
5.497e-03	-5.20	regulation of sequestering of calcium ion	biological process	GO:0051282	133	3	18204	49	RYR3,ITPR2,ATP1A2
5.500e-03	-5.20	Par3_HAL_N_term	pfam domains	PF12053	2	1	17795	49	PARD3B
5.545e-03	-5.19	neutral L-amino acid transmembrane transporter activity	molecular function	GO:0015175	42	2	18094	48	SLC1A3,SLC1A2
5.611e-03	-5.18	cytoskeleton organization	biological process	GO:0007010	1251	9	18204	49	CTNNA2,PARD3B,SORBS1,ABLIM1,FMN2,DST,NEBL,MACF1,TNIK
5.623e-03	-5.18	Aldosterone-regulated sodium reabsorption	KEGG pathways	hsa04960	37	2	7161	22	ATP1A2,PRKCA
5.623e-03	-5.18	Aldosterone-regulated sodium reabsorption	KEGG pathways	ko04960	37	2	7161	22	PRKCA,ATP1A2
5.731e-03	-5.16	I-set	pfam domains	PF07679	132	3	17795	49	NTM,NTRK2,LSAMP
5.732e-03	-5.16	Vascular smooth muscle contraction	KEGG pathways	hsa04270	121	3	7161	22	ITPR2,ADCY2,PRKCA
5.732e-03	-5.16	Vascular smooth muscle contraction	KEGG pathways	ko04270	121	3	7161	22	PRKCA,ADCY2,ITPR2
5.755e-03	-5.16	clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	clear_cell_renal_cell_carcinoma	13924	47	16828	49	SORBS1,DTNA,GPC5,PAMR1,RYR3,MSI2,PARD3B,ABLIM1,SLC4A4,ZBTB20,GLIS3,TPD52L1,NRG3,FMN2,DPP10,CTNND2,RORA,GLI3,GPM6A,PREX2,MGAT4C,TRPM3,NPAS3,NKAIN3,SLC1A2,FBXL7,LSAMP,PTPRZ1,ADCY2,NTRK2,CDH20,SPARCL1,NHSL1,PITPNC1,DST,SLC1A3,SOX5,TNIK,NEBL,BMPR1B,CSGALNACT1,MACF1,MAML2,NFIA,PRKCA,ATP1A2,ITPR2
5.755e-03	-5.16	kidney-carcinoma-clear_cell_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-clear_cell_renal_cell_carcinoma	13924	47	16828	49	PTPRZ1,LSAMP,FBXL7,SLC1A2,NKAIN3,NPAS3,TRPM3,MGAT4C,GPM6A,PREX2,TNIK,SOX5,SLC1A3,DST,PITPNC1,NHSL1,SPARCL1,CDH20,NTRK2,ADCY2,MACF1,CSGALNACT1,BMPR1B,NEBL,ITPR2,ATP1A2,PRKCA,NFIA,MAML2,RYR3,PAMR1,GPC5,DTNA,SORBS1,ABLIM1,PARD3B,MSI2,CTNND2,DPP10,FMN2,NRG3,TPD52L1,ZBTB20,GLIS3,SLC4A4,GLI3,RORA
5.767e-03	-5.16	sarcolemma	cellular component	GO:0042383	142	3	19108	49	ATP1A2,DTNA,RYR3
5.775e-03	-5.15	YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)	protein interactions	10971	1076	8	19454	50	NHSL1,DST,PRKCA,TPD52L1,ABLIM1,PARD3B,MACF1,SORBS1
5.797e-03	-5.15	Vinculin, Vh2 four-helix bundle	gene3d domains	1.20.120.810	2	1	14470	42	CTNNA2
5.797e-03	-5.15	-	gene3d domains	6.20.350.10	2	1	14470	42	RYR3
5.862e-03	-5.14	SH3	prosite domains	PS50002	222	4	12186	40	SORBS1,MACF1,NEBL,DST
5.885e-03	-5.14	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	COSMIC cancer mutations	central_nervous_system-brain-glioma-oligodendroglioma_Grade_III	249	4	16828	49	GLIS3,PTPRZ1,MACF1,MGAT4C
5.890e-03	-5.13	response to wounding	biological process	GO:0009611	431	5	18204	49	NFIA,DST,MACF1,SLC1A3,SLC1A2
5.935e-03	-5.13	active monoatomic ion transmembrane transporter activity	molecular function	GO:0022853	274	4	18094	48	ATP1A2,SLC1A2,SLC4A4,SLC1A3
5.968e-03	-5.12	small_intestine	COSMIC cancer mutations	small_intestine	250	4	16828	49	MGAT4C,CSGALNACT1,TNIK,MACF1
5.974e-03	-5.12	cell-substrate junction organization	biological process	GO:0150115	43	2	18204	49	DST,SORBS1
5.994e-03	-5.12	I band	cellular component	GO:0031674	144	3	19108	49	DST,NEBL,RYR3
6.088e-03	-5.10	regulation of generation of precursor metabolites and energy	biological process	GO:0043467	138	3	18204	49	SLC4A4,SORBS1,ZBTB20
6.107e-03	-5.10	axon	cellular component	GO:0030424	650	6	19108	49	GPM6A,SLC1A2,DST,CTNNA2,NTRK2,DTNA
6.174e-03	-5.09	vascular process in circulatory system	biological process	GO:0003018	273	4	18204	49	SLC1A3,SLC1A2,ATP1A2,SLC4A4
6.247e-03	-5.08	positive regulation of glucose transmembrane transport	biological process	GO:0010828	44	2	18204	49	SORBS1,SLC1A2
6.247e-03	-5.08	mammary gland morphogenesis	biological process	GO:0060443	44	2	18204	49	NRG3,GLI3
6.272e-03	-5.07	DSCR9 (Down syndrome critical region 9)	protein interactions	257203	146	3	19454	50	SPARCL1,MACF1,DST
6.281e-03	-5.07	animal organ development	biological process	GO:0048513	2846	15	18204	49	RORA,NRG3,CSGALNACT1,SOX5,GLI3,ATP1A2,NTRK2,CTNNA2,BMPR1B,NEBL,GPM6A,RFX4,ABLIM1,SLC1A2,NFIA
6.286e-03	-5.07	CCDC8 (coiled-coil domain containing 8)	protein interactions	83987	652	6	19454	50	NTRK2,ABLIM1,PRKCA,MACF1,DST,ITPR2
6.334e-03	-5.06	gliogenesis	biological process	GO:0042063	275	4	18204	49	NFIA,NTRK2,GLI3,PTPRZ1
6.335e-03	-5.06	neurotransmitter transport	biological process	GO:0006836	140	3	18204	49	ATP1A2,SLC1A2,SLC1A3
6.348e-03	-5.06	VASP (vasodilator stimulated phosphoprotein)	protein interactions	7408	288	4	19454	50	SORBS1,NEBL,FMN2,NHSL1
6.368e-03	-5.06	prostate-adenoma	COSMIC cancer mutations	prostate-adenoma	1634	11	16828	49	GPC5,MACF1,PTPRZ1,NPAS3,TRPM3,NEBL,ZBTB20,SOX5,DST,PRKCA,GLI3
6.416e-03	-5.05	cellular response to oxygen-containing compound	biological process	GO:1901701	1047	8	18204	49	ITPR2,SLC1A2,ZBTB20,ADCY2,SORBS1,SLC1A3,RORA,RYR3
6.441e-03	-5.05	membrane raft	cellular component	GO:0045121	290	4	19108	49	ATP1A2,SORBS1,ADCY2,SLC1A2
6.500e-03	-5.04	CNTN1 (contactin 1)	protein interactions	1272	47	2	19454	50	GPM6A,PTPRZ1
6.500e-03	-5.04	PTGER4 (prostaglandin E receptor 4)	protein interactions	5734	47	2	19454	50	CTNND2,DST
6.554e-03	-5.03	OSTEONECTIN_1	prosite domains	PS00612	2	1	12186	40	SPARCL1
6.554e-03	-5.03	OSTEONECTIN_2	prosite domains	PS00613	2	1	12186	40	SPARCL1
6.588e-03	-5.02	monoatomic anion transmembrane transport	biological process	GO:0098656	142	3	18204	49	SLC1A3,SLC1A2,SLC4A4
6.588e-03	-5.02	positive regulation of small molecule metabolic process	biological process	GO:0062013	142	3	18204	49	SORBS1,ZBTB20,SLC4A4
6.597e-03	-5.02	membrane microdomain	cellular component	GO:0098857	292	4	19108	49	SLC1A2,ATP1A2,SORBS1,ADCY2
6.634e-03	-5.02	GSE1 (Gse1 coiled-coil protein)	protein interactions	23199	149	3	19454	50	SOX5,TNIK,NFIA
6.646e-03	-5.01	skin-trunk-malignant_melanoma	COSMIC cancer mutations	skin-trunk-malignant_melanoma	2647	15	16828	49	MAML2,CDH20,DST,ATP1A2,SOX5,SLC1A3,NRG3,PREX2,NEBL,MGAT4C,CTNND2,PTPRZ1,RYR3,DPP10,LSAMP
6.691e-03	-5.01	Signaling by Hedgehog	REACTOME pathways	R-HSA-5358351	138	3	10285	29	GPC5,GLI3,ADCY2
6.757e-03	-5.00	KDM2B (lysine demethylase 2B)	protein interactions	84678	150	3	19454	50	NFIA,GLI3,SOX5
6.881e-03	-4.98	TNIK (TRAF2 and NCK interacting kinase)	protein interactions	23043	151	3	19454	50	MACF1,DST,TNIK
6.941e-03	-4.97	lung-carcinoma-bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	lung-carcinoma-bronchioloalveolar_adenocarcinoma	778	7	16828	49	BMPR1B,TNIK,SOX5,CTNND2,NTRK2,PRKCA,ADCY2
6.941e-03	-4.97	bronchioloalveolar_adenocarcinoma	COSMIC cancer mutations	bronchioloalveolar_adenocarcinoma	778	7	16828	49	BMPR1B,SOX5,CTNND2,TNIK,ADCY2,NTRK2,PRKCA
7.009e-03	-4.96	response to organic cyclic compound	biological process	GO:0014070	843	7	18204	49	ITPR2,ATP1A2,SLC1A2,ADCY2,SLC1A3,RORA,RYR3
7.087e-03	-4.95	symporter activity	molecular function	GO:0015293	148	3	18094	48	SLC1A2,SLC4A4,SLC1A3
7.103e-03	-4.95	regulation of neuron migration	biological process	GO:2001222	47	2	18204	49	NRG3,CTNNA2
7.111e-03	-4.95	mitotic cell cycle phase transition	biological process	GO:0044772	146	3	18204	49	FBXL7,TPD52L1,NFIA
7.111e-03	-4.95	adult behavior	biological process	GO:0030534	146	3	18204	49	ATP1A2,PREX2,SLC1A2
7.119e-03	-4.94	oligoastrocytoma_Grade_III	COSMIC cancer mutations	oligoastrocytoma_Grade_III	263	4	16828	49	SOX5,RYR3,SLC1A2,PREX2
7.240e-03	-4.93	Cardiac conduction	REACTOME pathways	R-HSA-5576891	142	3	10285	29	ITPR2,RYR3,ATP1A2
7.257e-03	-4.93	FORMIN	prints domains	PR00828	2	1	5227	19	FMN2
7.364e-03	-4.91	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	COSMIC cancer mutations	soft_tissue-striated_muscle-rhabdomyosarcoma-alveolar	2414	14	16828	49	SLC1A3,SPARCL1,NHSL1,CDH20,PARD3B,NFIA,PAMR1,RYR3,MACF1,FMN2,TRPM3,NPAS3,PREX2,SORBS1
7.364e-03	-4.91	alveolar	COSMIC cancer mutations	alveolar	2414	14	16828	49	CDH20,PARD3B,NFIA,SLC1A3,NHSL1,SPARCL1,NPAS3,TRPM3,SORBS1,PREX2,RYR3,MACF1,PAMR1,FMN2
7.404e-03	-4.91	large_intestine-adenoma	COSMIC cancer mutations	large_intestine-adenoma	266	4	16828	49	SOX5,RYR3,CDH20,GLI3
7.572e-03	-4.88	positive regulation of cell development	biological process	GO:0010720	458	5	18204	49	NTRK2,GLI3,PTPRZ1,PRKCA,MACF1
7.592e-03	-4.88	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-small_intestine-lymphoid_neoplasm-enteropathy_type_T_cell_lymphoma	45	2	16828	49	MGAT4C,MACF1
7.592e-03	-4.88	enteropathy_type_T_cell_lymphoma	COSMIC cancer mutations	enteropathy_type_T_cell_lymphoma	45	2	16828	49	MACF1,MGAT4C
7.607e-03	-4.88	positive regulation of cellular process	biological process	GO:0048522	5719	24	18204	49	SLC1A2,NFIA,SORBS1,PTPRZ1,NPAS3,GLIS3,TPD52L1,GPM6A,RFX4,MACF1,PRKCA,SOX5,GLI3,NTRK2,MAML2,FMN2,DPP10,SLC4A4,BMPR1B,ZBTB20,SLC1A3,RORA,TNIK,GPC5
7.617e-03	-4.88	Ndc80 (NDC80 kinetochore complex component)	protein interactions	67052	51	2	19454	50	NHSL1,MACF1
7.647e-03	-4.87	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-hairy_cell_leukaemia	1440	10	16828	49	CDH20,PREX2,RFX4,NEBL,MACF1,RYR3,CTNND2,PTPRZ1,DST,FMN2
7.647e-03	-4.87	hairy_cell_leukaemia	COSMIC cancer mutations	hairy_cell_leukaemia	1440	10	16828	49	FMN2,DST,MACF1,RYR3,CTNND2,PTPRZ1,NEBL,PREX2,RFX4,CDH20
7.674e-03	-4.87	alphav-beta3 integrin-PKCalpha complex	cellular component	GO:0035866	3	1	19108	49	PRKCA
7.691e-03	-4.87	Stk35 (serine/threonine kinase 35)	protein interactions	67333	3	1	19454	50	BMPR1B
7.691e-03	-4.87	BCO1 (beta-carotene oxygenase 1)	protein interactions	53630	3	1	19454	50	ABLIM1
7.691e-03	-4.87	Usp45 (ubiquitin specific petidase 45)	protein interactions	77593	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Shh (sonic hedgehog)	protein interactions	20423	3	1	19454	50	GLI3
7.691e-03	-4.87	Rap2a (RAS related protein 2a)	protein interactions	76108	3	1	19454	50	BMPR1B
7.691e-03	-4.87	IL34 (interleukin 34)	protein interactions	146433	3	1	19454	50	PTPRZ1
7.691e-03	-4.87	Chn1 (chimerin 1)	protein interactions	108699	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Smad6 (SMAD family member 6)	protein interactions	17130	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Spop (speckle-type BTB/POZ protein)	protein interactions	20747	3	1	19454	50	GLIS3
7.691e-03	-4.87	Fbxw5 (F-box and WD-40 domain protein 5)	protein interactions	30839	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Grm5 (glutamate metabotropic receptor 5)	protein interactions	24418	3	1	19454	50	PRKCA
7.691e-03	-4.87	Atg16l1 (autophagy related 16 like 1)	protein interactions	77040	3	1	19454	50	BMPR1B
7.691e-03	-4.87	Plekhb1 (pleckstrin homology domain containing, family B (evectins) member 1)	protein interactions	27276	3	1	19454	50	BMPR1B
7.691e-03	-4.87	QRFPR (pyroglutamylated RFamide peptide receptor)	protein interactions	84109	3	1	19454	50	NTM
7.700e-03	-4.87	G2/M transition of mitotic cell cycle	biological process	GO:0000086	49	2	18204	49	FBXL7,TPD52L1
7.720e-03	-4.86	endometrium-carcinoma-serous_carcinoma	COSMIC cancer mutations	endometrium-carcinoma-serous_carcinoma	1442	10	16828	49	CTNND2,RYR3,TNIK,LSAMP,GPC5,DST,FMN2,TRPM3,SORBS1,SLC4A4
7.762e-03	-4.86	anchoring junction	cellular component	GO:0070161	902	7	19108	49	CTNND2,CTNNA2,PARD3B,ATP1A2,SORBS1,CDH20,DST
7.800e-03	-4.85	abdomen	COSMIC cancer mutations	abdomen	603	6	16828	49	FMN2,DST,PREX2,DPP10,CTNND2,ITPR2
7.909e-03	-4.84	SH2B2 (SH2B adaptor protein 2)	protein interactions	10603	52	2	19454	50	NTRK2,SORBS1
7.923e-03	-4.84	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-follicular_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-abdomen-lymphoid_neoplasm-follicular_lymphoma	46	2	16828	49	ITPR2,DPP10
7.928e-03	-4.84	DTNBP1 (dystrobrevin binding protein 1)	protein interactions	84062	159	3	19454	50	DST,MACF1,DTNA
7.938e-03	-4.84	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	molecular function	GO:0008454	3	1	18094	48	MGAT4C
7.938e-03	-4.84	cysteine transmembrane transporter activity	molecular function	GO:0033229	3	1	18094	48	SLC1A2
7.938e-03	-4.84	inositol 1,4,5-trisphosphate-gated calcium channel activity	molecular function	GO:0005220	3	1	18094	48	ITPR2
7.938e-03	-4.84	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	molecular function	GO:0047237	3	1	18094	48	CSGALNACT1
7.991e-03	-4.83	G alpha (z) signalling events	REACTOME pathways	R-HSA-418597	48	2	10285	29	ADCY2,PRKCA
8.054e-03	-4.82	regulation of calcium:sodium antiporter activity	biological process	GO:1903279	3	1	18204	49	ATP1A2
8.054e-03	-4.82	meiotic chromosome movement towards spindle pole	biological process	GO:0016344	3	1	18204	49	FMN2
8.054e-03	-4.82	radial glia guided migration of Purkinje cell	biological process	GO:0021942	3	1	18204	49	CTNNA2
8.054e-03	-4.82	mammary placode formation	biological process	GO:0060596	3	1	18204	49	NRG3
8.054e-03	-4.82	cysteine transport	biological process	GO:0042883	3	1	18204	49	SLC1A2
8.054e-03	-4.82	formin-nucleated actin cable assembly	biological process	GO:0070649	3	1	18204	49	FMN2
8.054e-03	-4.82	smoothened signaling pathway involved in ventral spinal cord patterning	biological process	GO:0021910	3	1	18204	49	GLI3
8.054e-03	-4.82	regulation of dense core granule biogenesis	biological process	GO:2000705	3	1	18204	49	PRKCA
8.054e-03	-4.82	nose morphogenesis	biological process	GO:0043585	3	1	18204	49	GLI3
8.054e-03	-4.82	trans-synaptic signaling by BDNF, modulating synaptic transmission	biological process	GO:0099183	3	1	18204	49	NTRK2
8.054e-03	-4.82	formin-nucleated actin cable organization	biological process	GO:0110009	3	1	18204	49	FMN2
8.054e-03	-4.82	smoothened signaling pathway involved in ventral spinal cord interneuron specification	biological process	GO:0021775	3	1	18204	49	GLI3
8.054e-03	-4.82	cysteine transmembrane transport	biological process	GO:1903712	3	1	18204	49	SLC1A2
8.054e-03	-4.82	UDP-N-acetylgalactosamine metabolic process	biological process	GO:0019276	3	1	18204	49	CSGALNACT1
8.054e-03	-4.82	cardiac muscle thin filament assembly	biological process	GO:0071691	3	1	18204	49	NEBL
8.078e-03	-4.82	SPRY3_RyR	interpro domains	IPR035762	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK_LRRCT	interpro domains	IPR031635	3	1	18521	50	NTRK2
8.078e-03	-4.82	Myelin_PLP_CS	interpro domains	IPR018237	3	1	18521	50	GPM6A
8.078e-03	-4.82	SPRY2_RyR	interpro domains	IPR035764	3	1	18521	50	RYR3
8.078e-03	-4.82	NTRK	interpro domains	IPR020777	3	1	18521	50	NTRK2
8.078e-03	-4.82	RYDR_Jsol	interpro domains	IPR048581	3	1	18521	50	RYR3
8.078e-03	-4.82	Mastermind-like_N	interpro domains	IPR019082	3	1	18521	50	MAML2
8.078e-03	-4.82	MAML1-3	interpro domains	IPR046369	3	1	18521	50	MAML2
8.078e-03	-4.82	SPRY1_RyR	interpro domains	IPR035761	3	1	18521	50	RYR3
8.078e-03	-4.82	Protein_kinase_C_a/b/g	interpro domains	IPR014375	3	1	18521	50	PRKCA
8.078e-03	-4.82	Vinculin_CS	interpro domains	IPR000633	3	1	18521	50	CTNNA2
8.078e-03	-4.82	Ryanodine_rcpt	interpro domains	IPR003032	3	1	18521	50	RYR3
8.078e-03	-4.82	ROR_rcpt	interpro domains	IPR003079	3	1	18521	50	RORA
8.078e-03	-4.82	MAML_N_sf	interpro domains	IPR046370	3	1	18521	50	MAML2
8.078e-03	-4.82	Myelin_PLP	interpro domains	IPR001614	3	1	18521	50	GPM6A
8.078e-03	-4.82	NR_DBD_ROR	interpro domains	IPR044101	3	1	18521	50	RORA
8.078e-03	-4.82	Neuregulin	interpro domains	IPR040180	3	1	18521	50	NRG3
8.078e-03	-4.82	InsP3_rcpt	interpro domains	IPR000493	3	1	18521	50	ITPR2
8.078e-03	-4.82	Ryanrecept_TM4-6	interpro domains	IPR009460	3	1	18521	50	RYR3
8.078e-03	-4.82	SoHo_dom	interpro domains	IPR003127	3	1	18521	50	SORBS1
8.078e-03	-4.82	Ryan_recept	interpro domains	IPR013333	3	1	18521	50	RYR3
8.100e-03	-4.82	AFDN (afadin, adherens junction formation factor)	protein interactions	4301	309	4	19454	50	MACF1,DST,SORBS1,DTNA
8.124e-03	-4.81	neuronal cell body	cellular component	GO:0043025	489	5	19108	49	SLC1A3,CTNND2,GPM6A,ATP1A2,BMPR1B
8.135e-03	-4.81	urinary_tract-bladder-carcinoma	COSMIC cancer mutations	urinary_tract-bladder-carcinoma	14050	47	16828	49	MGAT4C,TRPM3,NPAS3,NTM,PREX2,GPM6A,LSAMP,PTPRZ1,SLC1A2,FBXL7,NTRK2,CDH20,ADCY2,SLC1A3,SOX5,TNIK,SPARCL1,PITPNC1,DST,NEBL,BMPR1B,CSGALNACT1,MACF1,PRKCA,MAML2,NFIA,ITPR2,ATP1A2,DTNA,SORBS1,GPC5,PAMR1,RYR3,PARD3B,MSI2,ABLIM1,SLC4A4,GLIS3,RFX4,ZBTB20,TPD52L1,NRG3,DPP10,CTNND2,FMN2,GLI3,RORA
8.172e-03	-4.81	positive regulation of nervous system development	biological process	GO:0051962	296	4	18204	49	NTRK2,PTPRZ1,GLI3,MACF1
8.206e-03	-4.80	MAL2 (mal, T cell differentiation protein 2)	protein interactions	114569	53	2	19454	50	PITPNC1,TPD52L1
8.230e-03	-4.80	calcium-mediated signaling	biological process	GO:0019722	154	3	18204	49	ITPR2,ATP1A2,RYR3
8.238e-03	-4.80	RR_TM4-6	pfam domains	PF06459	3	1	17795	49	RYR3
8.238e-03	-4.80	Sorb	pfam domains	PF02208	3	1	17795	49	SORBS1
8.238e-03	-4.80	MamL-1	pfam domains	PF09596	3	1	17795	49	MAML2
8.238e-03	-4.80	RyR	pfam domains	PF02026	3	1	17795	49	RYR3
8.238e-03	-4.80	LRRCT_2	pfam domains	PF16920	3	1	17795	49	NTRK2
8.238e-03	-4.80	RYDR_Jsol	pfam domains	PF21119	3	1	17795	49	RYR3
8.238e-03	-4.80	Myelin_PLP	pfam domains	PF01275	3	1	17795	49	GPM6A
8.244e-03	-4.80	transmembrane transporter activity	molecular function	GO:0022857	1110	8	18094	48	ITPR2,TRPM3,ATP1A2,GPM6A,SLC1A2,SLC4A4,RYR3,SLC1A3
8.247e-03	-4.80	Apelin signaling pathway	KEGG pathways	hsa04371	138	3	7161	22	ITPR2,ADCY2,RYR3
8.387e-03	-4.78	cell cortex	cellular component	GO:0005938	313	4	19108	49	ITPR2,PARD3B,FMN2,DST
8.436e-03	-4.78	GLI proteins bind promoters of Hh responsive genes to promote transcription	REACTOME pathways	R-HSA-5635851	3	1	10285	29	GLI3
8.476e-03	-4.77	integrin binding	molecular function	GO:0005178	158	3	18094	48	PRKCA,PTPRZ1,DST
8.638e-03	-4.75	regulation of purine nucleotide catabolic process	biological process	GO:0033121	52	2	18204	49	ZBTB20,SLC4A4
8.638e-03	-4.75	regulation of glycolytic process	biological process	GO:0006110	52	2	18204	49	ZBTB20,SLC4A4
8.638e-03	-4.75	regulation of nucleotide catabolic process	biological process	GO:0030811	52	2	18204	49	ZBTB20,SLC4A4
8.683e-03	-4.75	-	gene3d domains	1.10.490.160	3	1	14470	42	RYR3
8.683e-03	-4.75	-	gene3d domains	6.10.250.2510	3	1	14470	42	CTNNA2
8.683e-03	-4.75	-	gene3d domains	6.10.250.970	3	1	14470	42	MAML2
8.748e-03	-4.74	ZYX (zyxin)	protein interactions	7791	316	4	19454	50	NEBL,ABLIM1,SORBS1,MACF1
8.917e-03	-4.72	SCLT1 (sodium channel and clathrin linker 1)	protein interactions	132320	166	3	19454	50	NEBL,ATP1A2,ABLIM1
8.959e-03	-4.72	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	ko04961	47	2	7161	22	PRKCA,ATP1A2
8.959e-03	-4.72	Endocrine and other factor-regulated calcium reabsorption	KEGG pathways	hsa04961	47	2	7161	22	PRKCA,ATP1A2
8.962e-03	-4.71	neutral amino acid transport	biological process	GO:0015804	53	2	18204	49	SLC1A2,SLC1A3
8.979e-03	-4.71	cell cycle phase transition	biological process	GO:0044770	159	3	18204	49	TPD52L1,FBXL7,NFIA
8.979e-03	-4.71	monoatomic anion transport	biological process	GO:0006820	159	3	18204	49	SLC4A4,SLC1A2,SLC1A3
8.986e-03	-4.71	Chondroitin sulfate/dermatan sulfate metabolism	REACTOME pathways	R-HSA-1793185	51	2	10285	29	GPC5,CSGALNACT1
8.986e-03	-4.71	Signaling by ERBB2	REACTOME pathways	R-HSA-1227986	51	2	10285	29	PRKCA,NRG3
8.986e-03	-4.71	Neurotransmitter Release Cycle	REACTOME pathways	R-HSA-112310	51	2	10285	29	SLC1A2,SLC1A3
9.015e-03	-4.71	calcium ion binding	molecular function	GO:0005509	683	6	18094	48	ITPR2,PAMR1,SPARCL1,DST,RYR3,MACF1
9.231e-03	-4.69	ACTA1 (actin alpha 1, skeletal muscle)	protein interactions	58	321	4	19454	50	MACF1,PRKCA,SORBS1,DTNA
9.268e-03	-4.68	Adrenergic signaling in cardiomyocytes	KEGG pathways	ko04261	144	3	7161	22	PRKCA,ADCY2,ATP1A2
9.268e-03	-4.68	Adrenergic signaling in cardiomyocytes	KEGG pathways	hsa04261	144	3	7161	22	ADCY2,ATP1A2,PRKCA
9.290e-03	-4.68	cell cycle G2/M phase transition	biological process	GO:0044839	54	2	18204	49	FBXL7,TPD52L1
9.621e-03	-4.64	urinary_tract	COSMIC cancer mutations	urinary_tract	14112	47	16828	49	NEBL,BMPR1B,MACF1,CSGALNACT1,MAML2,NFIA,PRKCA,ATP1A2,ITPR2,GPM6A,PREX2,NTM,MGAT4C,NPAS3,TRPM3,FBXL7,SLC1A2,LSAMP,PTPRZ1,ADCY2,NTRK2,CDH20,SPARCL1,DST,PITPNC1,SLC1A3,TNIK,SOX5,SLC4A4,NRG3,TPD52L1,ZBTB20,RFX4,GLIS3,FMN2,DPP10,CTNND2,RORA,GLI3,SORBS1,DTNA,GPC5,RYR3,PAMR1,MSI2,PARD3B,ABLIM1
9.621e-03	-4.64	bladder	COSMIC cancer mutations	bladder	14112	47	16828	49	SLC4A4,RFX4,GLIS3,ZBTB20,TPD52L1,NRG3,DPP10,CTNND2,FMN2,GLI3,RORA,DTNA,SORBS1,GPC5,PAMR1,RYR3,PARD3B,MSI2,ABLIM1,NEBL,BMPR1B,CSGALNACT1,MACF1,PRKCA,MAML2,NFIA,ITPR2,ATP1A2,MGAT4C,TRPM3,NPAS3,NTM,GPM6A,PREX2,LSAMP,PTPRZ1,SLC1A2,FBXL7,NTRK2,CDH20,ADCY2,SLC1A3,SOX5,TNIK,SPARCL1,PITPNC1,DST
9.625e-03	-4.64	response to cocaine	biological process	GO:0042220	55	2	18204	49	SLC1A2,SLC1A3
9.634e-03	-4.64	biliary_tract	COSMIC cancer mutations	biliary_tract	15309	49	16828	49	NFIA,MAML2,PRKCA,ATP1A2,ITPR2,NEBL,CSGALNACT1,MACF1,BMPR1B,ADCY2,CDH20,NTRK2,PITPNC1,DST,SPARCL1,NHSL1,SOX5,TNIK,SLC1A3,NTM,GPM6A,PREX2,TRPM3,NPAS3,MGAT4C,SLC1A2,FBXL7,NKAIN3,PTPRZ1,LSAMP,RORA,GLI3,GLIS3,RFX4,ZBTB20,NRG3,TPD52L1,SLC4A4,FMN2,CTNND2,DPP10,MSI2,PARD3B,ABLIM1,SORBS1,DTNA,PAMR1,RYR3,GPC5
9.634e-03	-4.64	LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 1)	protein interactions	55004	714	6	19454	50	TPD52L1,SLC1A3,DST,FMN2,DTNA,TNIK
9.670e-03	-4.64	haematopoietic_and_lymphoid_tissue-tonsil-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-tonsil-lymphoid_neoplasm-diffuse_large_B_cell_lymphoma	51	2	16828	49	ITPR2,DPP10
9.751e-03	-4.63	dendritic spine	cellular component	GO:0043197	172	3	19108	49	NTRK2,ATP1A2,GPM6A
9.763e-03	-4.63	SNAP25 (synaptosome associated protein 25)	protein interactions	6616	58	2	19454	50	PRKCA,GPM6A
9.816e-03	-4.62	VINCULIN_1	prosite domains	PS00663	3	1	12186	40	CTNNA2
9.816e-03	-4.62	MYELIN_PLP_2	prosite domains	PS01004	3	1	12186	40	GPM6A
9.816e-03	-4.62	MYELIN_PLP_1	prosite domains	PS00575	3	1	12186	40	GPM6A
9.816e-03	-4.62	SOHO	prosite domains	PS50831	3	1	12186	40	SORBS1
9.914e-03	-4.61	Signalling by NGF	REACTOME pathways	R-HSA-166520	477	5	10285	29	NTRK2,NRG3,ITPR2,ADCY2,PRKCA
9.929e-03	-4.61	import across plasma membrane	biological process	GO:0098739	165	3	18204	49	SLC1A3,SLC1A2,ATP1A2
9.950e-03	-4.61	CAV1 (caveolin 1)	protein interactions	857	719	6	19454	50	DST,MACF1,SLC1A3,TNIK,DTNA,FMN2
9.964e-03	-4.61	release of sequestered calcium ion into cytosol	biological process	GO:0051209	56	2	18204	49	ITPR2,RYR3
1.006e-02	-4.60	neuron spine	cellular component	GO:0044309	174	3	19108	49	ATP1A2,GPM6A,NTRK2
1.009e-02	-4.60	HTATIP2 (HIV-1 Tat interactive protein 2)	protein interactions	10553	59	2	19454	50	PRKCA,PITPNC1
1.013e-02	-4.59	APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1)	protein interactions	26060	174	3	19454	50	DST,NTRK2,DTNA
1.022e-02	-4.58	extrinsic component of membrane	cellular component	GO:0019898	175	3	19108	49	DTNA,CDH20,CTNNA2
1.022e-02	-4.58	GLI-SUFU complex	cellular component	GO:1990788	4	1	19108	49	GLI3
1.023e-02	-4.58	positive regulation of cell differentiation	biological process	GO:0045597	906	7	18204	49	MACF1,PTPRZ1,BMPR1B,PRKCA,SOX5,GLI3,NTRK2
1.024e-02	-4.58	Cdk14 (cyclin dependent kinase 14)	protein interactions	18647	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nkiras1 (NFKB inhibitor interacting Ras-like protein 1)	protein interactions	69721	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Rhebl1 (Ras homolog enriched in brain like 1)	protein interactions	69159	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Nme2 (NME/NM23 nucleoside diphosphate kinase 2)	protein interactions	18103	4	1	19454	50	RORA
1.024e-02	-4.58	CCDC126 (coiled-coil domain containing 126)	protein interactions	90693	4	1	19454	50	GPM6A
1.024e-02	-4.58	Srgap1 (SLIT-ROBO Rho GTPase activating protein 1)	protein interactions	117600	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Dnaja1 (DnaJ heat shock protein family (Hsp40) member A1)	protein interactions	15502	4	1	19454	50	GLIS3
1.024e-02	-4.58	Naa20 (N(alpha)-acetyltransferase 20, NatB catalytic subunit)	protein interactions	67877	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Pick1 (protein interacting with PRKCA 1)	protein interactions	84591	4	1	19454	50	PRKCA
1.024e-02	-4.58	Sufu (SUFU negative regulator of hedgehog signaling)	protein interactions	24069	4	1	19454	50	GLI3
1.024e-02	-4.58	Tpd52 (tumor protein D52)	protein interactions	21985	4	1	19454	50	TPD52L1
1.024e-02	-4.58	Arhgef6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	73341	4	1	19454	50	BMPR1B
1.024e-02	-4.58	Ilkap (integrin-linked kinase-associated serine/threonine phosphatase 2C)	protein interactions	67444	4	1	19454	50	BMPR1B
1.024e-02	-4.58	AVPR1A (arginine vasopressin receptor 1A)	protein interactions	552	4	1	19454	50	PRKCA
1.031e-02	-4.57	neuroblast proliferation	biological process	GO:0007405	57	2	18204	49	GLI3,SOX5
1.031e-02	-4.57	visual behavior	biological process	GO:0007632	57	2	18204	49	SLC1A2,ATP1A2
1.031e-02	-4.57	negative regulation of sequestering of calcium ion	biological process	GO:0051283	57	2	18204	49	ITPR2,RYR3
1.037e-02	-4.57	cellular component biogenesis	biological process	GO:0044085	2716	14	18204	49	TNIK,NRG3,TRPM3,RYR3,DST,FMN2,PRKCA,CDH20,RFX4,NEBL,GPM6A,SLC1A2,ABLIM1,SORBS1
1.057e-02	-4.55	brain-derived neurotrophic factor binding	molecular function	GO:0048403	4	1	18094	48	NTRK2
1.057e-02	-4.55	mediator complex binding	molecular function	GO:0036033	4	1	18094	48	GLI3
1.057e-02	-4.55	ryanodine-sensitive calcium-release channel activity	molecular function	GO:0005219	4	1	18094	48	RYR3
1.065e-02	-4.54	ovary-other-neoplasm	COSMIC cancer mutations	ovary-other-neoplasm	12717	44	16828	49	BMPR1B,MACF1,CSGALNACT1,NEBL,ATP1A2,ITPR2,MAML2,PRKCA,NKAIN3,FBXL7,SLC1A2,LSAMP,GPM6A,PREX2,NTM,MGAT4C,TRPM3,NHSL1,SPARCL1,DST,SLC1A3,TNIK,SOX5,ADCY2,NTRK2,CDH20,FMN2,DPP10,CTNND2,SLC4A4,NRG3,TPD52L1,RFX4,GLIS3,ZBTB20,RORA,GLI3,GPC5,RYR3,PAMR1,SORBS1,ABLIM1,MSI2,PARD3B
1.072e-02	-4.54	frontal suture morphogenesis	biological process	GO:0060364	4	1	18204	49	GLI3
1.072e-02	-4.54	regulation of angiotensin-activated signaling pathway	biological process	GO:0110061	4	1	18204	49	PRKCA
1.072e-02	-4.54	ovarian cumulus expansion	biological process	GO:0001550	4	1	18204	49	BMPR1B
1.072e-02	-4.54	trans-synaptic signaling by BDNF	biological process	GO:0099191	4	1	18204	49	NTRK2
1.072e-02	-4.54	brain-derived neurotrophic factor receptor signaling pathway	biological process	GO:0031547	4	1	18204	49	NTRK2
1.072e-02	-4.54	regulation of glutamate uptake involved in transmission of nerve impulse	biological process	GO:0051946	4	1	18204	49	ATP1A2
1.072e-02	-4.54	positive regulation of mesenchymal stem cell differentiation	biological process	GO:2000741	4	1	18204	49	SOX5
1.072e-02	-4.54	desmosome assembly	biological process	GO:0002159	4	1	18204	49	PRKCA
1.072e-02	-4.54	response to glycoside	biological process	GO:1903416	4	1	18204	49	ATP1A2
1.072e-02	-4.54	smoothened signaling pathway involved in dorsal/ventral neural tube patterning	biological process	GO:0060831	4	1	18204	49	GLI3
1.072e-02	-4.54	regulation of amino acid uptake involved in synaptic transmission	biological process	GO:0051941	4	1	18204	49	ATP1A2
1.076e-02	-4.53	TRPM_tetra	interpro domains	IPR032415	4	1	18521	50	TRPM3
1.076e-02	-4.53	NHS-like	interpro domains	IPR024845	4	1	18521	50	NHSL1
1.076e-02	-4.53	CTF/NFI_DNA-bd_N	interpro domains	IPR019548	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd_CS	interpro domains	IPR019739	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI	interpro domains	IPR000647	4	1	18521	50	NFIA
1.076e-02	-4.53	CTF/NFI_DNA-bd-dom	interpro domains	IPR020604	4	1	18521	50	NFIA
1.076e-02	-4.53	Na/K-Atpase_Interacting	interpro domains	IPR008516	4	1	18521	50	NKAIN3
1.076e-02	-4.53	Nebulin_repeat	interpro domains	IPR000900	4	1	18521	50	NEBL
1.076e-02	-4.53	AbLIM_anchor	interpro domains	IPR032402	4	1	18521	50	ABLIM1
1.076e-02	-4.53	Alpha_catenin	interpro domains	IPR001033	4	1	18521	50	CTNNA2
1.076e-02	-4.53	TPD52	interpro domains	IPR007327	4	1	18521	50	TPD52L1
1.076e-02	-4.53	TRPM_tetra_sf	interpro domains	IPR037162	4	1	18521	50	TRPM3
1.076e-02	-4.53	Glyco_transf_54	interpro domains	IPR006759	4	1	18521	50	MGAT4C
1.076e-02	-4.53	PRKG1 (protein kinase cGMP-dependent 1)	protein interactions	5592	61	2	19454	50	TNIK,PRKCA
1.077e-02	-4.53	MamL-1	smart domains	SM01275	3	1	9717	35	MAML2
1.077e-02	-4.53	PLP	smart domains	SM00002	3	1	9717	35	GPM6A
1.077e-02	-4.53	Sorb	smart domains	SM00459	3	1	9717	35	SORBS1
1.077e-02	-4.53	CEP63 (centrosomal protein 63)	protein interactions	80254	178	3	19454	50	DST,MACF1,TNIK
1.082e-02	-4.53	skeletal system development	biological process	GO:0001501	500	5	18204	49	CSGALNACT1,BMPR1B,NFIA,SOX5,GLI3
1.087e-02	-4.52	RYANODINER	prints domains	PR00795	3	1	5227	19	RYR3
1.087e-02	-4.52	MYELINPLP	prints domains	PR00214	3	1	5227	19	GPM6A
1.087e-02	-4.52	INSP3RECEPTR	prints domains	PR00779	3	1	5227	19	ITPR2
1.087e-02	-4.52	RORNUCRECPTR	prints domains	PR01293	3	1	5227	19	RORA
1.087e-02	-4.52	NTKRECEPTOR	prints domains	PR01939	3	1	5227	19	NTRK2
1.096e-02	-4.51	mucosal	COSMIC cancer mutations	mucosal	2009	12	16828	49	BMPR1B,CTNND2,FMN2,MGAT4C,NEBL,SORBS1,PREX2,NRG3,ABLIM1,SPARCL1,ATP1A2,RORA
1.096e-02	-4.51	skin-mucosal-malignant_melanoma	COSMIC cancer mutations	skin-mucosal-malignant_melanoma	2009	12	16828	49	MGAT4C,PREX2,SORBS1,NRG3,NEBL,CTNND2,BMPR1B,FMN2,RORA,ABLIM1,SPARCL1,ATP1A2
1.097e-02	-4.51	TPD52	pfam domains	PF04201	4	1	17795	49	TPD52L1
1.097e-02	-4.51	NHS	pfam domains	PF15273	4	1	17795	49	NHSL1
1.097e-02	-4.51	TRPM_tetra	pfam domains	PF16519	4	1	17795	49	TRPM3
1.097e-02	-4.51	CTF_NFI	pfam domains	PF00859	4	1	17795	49	NFIA
1.097e-02	-4.51	Glyco_transf_54	pfam domains	PF04666	4	1	17795	49	MGAT4C
1.097e-02	-4.51	AbLIM_anchor	pfam domains	PF16182	4	1	17795	49	ABLIM1
1.097e-02	-4.51	NKAIN	pfam domains	PF05640	4	1	17795	49	NKAIN3
1.097e-02	-4.51	Nebulin	pfam domains	PF00880	4	1	17795	49	NEBL
1.097e-02	-4.51	NfI_DNAbd_pre-N	pfam domains	PF10524	4	1	17795	49	NFIA
1.098e-02	-4.51	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-tibia-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	649	6	16828	49	ABLIM1,MACF1,TNIK,DST,TRPM3,PREX2
1.098e-02	-4.51	primitive_neuroectodermal_tumour-medulloblastoma	COSMIC cancer mutations	primitive_neuroectodermal_tumour-medulloblastoma	15350	49	16828	49	MSI2,PARD3B,ABLIM1,SORBS1,DTNA,RYR3,PAMR1,GPC5,RORA,GLI3,NRG3,TPD52L1,ZBTB20,RFX4,GLIS3,SLC4A4,FMN2,CTNND2,DPP10,ADCY2,CDH20,NTRK2,DST,PITPNC1,NHSL1,SPARCL1,TNIK,SOX5,SLC1A3,GPM6A,PREX2,NTM,NPAS3,TRPM3,MGAT4C,FBXL7,SLC1A2,NKAIN3,PTPRZ1,LSAMP,NFIA,MAML2,PRKCA,ATP1A2,ITPR2,NEBL,MACF1,CSGALNACT1,BMPR1B
1.101e-02	-4.51	endochondral bone morphogenesis	biological process	GO:0060350	59	2	18204	49	CSGALNACT1,BMPR1B
1.106e-02	-4.50	chondroitin biosynthesis	BIOCYC pathways	META_PWY-6566	5	1	902	2	CSGALNACT1
1.110e-02	-4.50	MYOD1 (myogenic differentiation 1)	protein interactions	4654	180	3	19454	50	RORA,PRKCA,NFIA
1.118e-02	-4.49	parathyroid-carcinoma	COSMIC cancer mutations	parathyroid-carcinoma	300	4	16828	49	MACF1,RYR3,PAMR1,GPC5
1.121e-02	-4.49	EF_Hand_1_Ca_BS	interpro domains	IPR018247	172	3	18521	50	DST,MACF1,SPARCL1
1.126e-02	-4.49	cellular response to organonitrogen compound	biological process	GO:0071417	505	5	18204	49	RYR3,SORBS1,SLC1A3,ITPR2,SLC1A2
1.137e-02	-4.48	monoatomic cation channel activity	molecular function	GO:0005261	331	4	18094	48	GPM6A,RYR3,TRPM3,ITPR2
1.137e-02	-4.48	proteoglycan biosynthetic process	biological process	GO:0030166	60	2	18204	49	CSGALNACT1,BMPR1B
1.137e-02	-4.48	transmission of nerve impulse	biological process	GO:0019226	60	2	18204	49	ATP1A2,NTRK2
1.137e-02	-4.48	export across plasma membrane	biological process	GO:0140115	60	2	18204	49	SLC4A4,ATP1A2
1.137e-02	-4.48	regulation of glucose import	biological process	GO:0046324	60	2	18204	49	SORBS1,SLC1A2
1.143e-02	-4.47	human chr4q34.2	chromosome location	human chr4q34.2	6	1	26134	50	GPM6A
1.143e-02	-4.47	human chr14q13.1	chromosome location	human chr14q13.1	6	1	26134	50	NPAS3
1.156e-02	-4.46	oligodendroglioma_Grade_III	COSMIC cancer mutations	oligodendroglioma_Grade_III	303	4	16828	49	GLIS3,MGAT4C,MACF1,PTPRZ1
1.156e-02	-4.46	TRPM, tetramerisation domain	gene3d domains	1.20.5.1010	4	1	14470	42	TRPM3
1.160e-02	-4.46	skin-lower_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-nodular	4	1	16828	49	PREX2
1.160e-02	-4.46	skin-face-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-face-malignant_melanoma-superficial_spreading	4	1	16828	49	PREX2
1.165e-02	-4.45	Activation of PKC Through G Protein-Coupled Receptor	SMPDB pathways	SMP0000749	4	1	1369	4	PRKCA
1.167e-02	-4.45	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-peripheral_T_cell_lymphoma_unspecified	162	3	16828	49	MACF1,RYR3,ITPR2
1.179e-02	-4.44	SYNC (syncoilin, intermediate filament protein)	protein interactions	81493	64	2	19454	50	DTNA,MAML2
1.179e-02	-4.44	VSX1 (visual system homeobox 1)	protein interactions	30813	64	2	19454	50	DST,NFIA
1.184e-02	-4.44	cadherin binding	molecular function	GO:0045296	335	4	18094	48	CTNNA2,CDH20,MACF1,CTNND2
1.188e-02	-4.43	skin-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-head_neck-carcinoma-squamous_cell_carcinoma	14191	47	16828	49	FMN2,DPP10,CTNND2,SLC4A4,NRG3,RFX4,GLIS3,ZBTB20,RORA,GLI3,GPC5,RYR3,PAMR1,SORBS1,DTNA,ABLIM1,PARD3B,BMPR1B,MACF1,CSGALNACT1,NEBL,ATP1A2,ITPR2,MAML2,NFIA,PRKCA,NKAIN3,FBXL7,SLC1A2,LSAMP,PTPRZ1,PREX2,GPM6A,NTM,MGAT4C,NPAS3,TRPM3,NHSL1,SPARCL1,DST,PITPNC1,SLC1A3,TNIK,SOX5,ADCY2,NTRK2,CDH20
1.196e-02	-4.43	regulation of small molecule metabolic process	biological process	GO:0062012	331	4	18204	49	RORA,SORBS1,ZBTB20,SLC4A4
1.198e-02	-4.42	membrane	cellular component	GO:0016020	9220	32	19108	49	PREX2,ITPR2,CTNNA2,LSAMP,MGAT4C,SORBS1,NKAIN3,ATP1A2,CDH20,TRPM3,NTRK2,GPM6A,SLC1A2,NTM,DPP10,DTNA,BMPR1B,SLC4A4,SLC1A3,CSGALNACT1,NRG3,FMN2,RYR3,GPC5,DST,ADCY2,PRKCA,PARD3B,CTNND2,MACF1,PTPRZ1,TNIK
1.209e-02	-4.42	kidney	COSMIC cancer mutations	kidney	15380	49	16828	49	NKAIN3,FBXL7,SLC1A2,LSAMP,PTPRZ1,PREX2,GPM6A,NTM,MGAT4C,NPAS3,TRPM3,NHSL1,SPARCL1,DST,PITPNC1,SLC1A3,TNIK,SOX5,ADCY2,NTRK2,CDH20,BMPR1B,MACF1,CSGALNACT1,NEBL,ATP1A2,ITPR2,MAML2,NFIA,PRKCA,GPC5,RYR3,PAMR1,SORBS1,DTNA,ABLIM1,MSI2,PARD3B,FMN2,DPP10,CTNND2,SLC4A4,TPD52L1,NRG3,RFX4,GLIS3,ZBTB20,RORA,GLI3
1.211e-02	-4.41	positive regulation of protein localization to plasma membrane	biological process	GO:1903078	62	2	18204	49	SORBS1,DPP10
1.211e-02	-4.41	regulation of carbohydrate catabolic process	biological process	GO:0043470	62	2	18204	49	ZBTB20,SLC4A4
1.211e-02	-4.41	telencephalon cell migration	biological process	GO:0022029	62	2	18204	49	GLI3,NRG3
1.216e-02	-4.41	parathyroid	COSMIC cancer mutations	parathyroid	476	5	16828	49	PAMR1,RYR3,MACF1,GPC5,GPM6A
1.250e-02	-4.38	MAML1 (mastermind like transcriptional coactivator 1)	protein interactions	9794	66	2	19454	50	MAML2,NFIA
1.266e-02	-4.37	peripheral_T_cell_lymphoma_unspecified	COSMIC cancer mutations	peripheral_T_cell_lymphoma_unspecified	167	3	16828	49	RYR3,MACF1,ITPR2
1.267e-02	-4.37	Ca2+ pathway	REACTOME pathways	R-HSA-4086398	61	2	10285	29	ITPR2,PRKCA
1.279e-02	-4.36	Rhoj (ras homolog family member J)	protein interactions	80837	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Cdk4 (cyclin dependent kinase 4)	protein interactions	12567	5	1	19454	50	BMPR1B
1.279e-02	-4.36	RFX4 (regulatory factor X4)	protein interactions	5992	5	1	19454	50	RFX4
1.279e-02	-4.36	DPP10 (dipeptidyl peptidase like 10)	protein interactions	57628	5	1	19454	50	DPP10
1.279e-02	-4.36	DLX3 (distal-less homeobox 3)	protein interactions	1747	5	1	19454	50	PRKCA
1.279e-02	-4.36	Rab6b (RAB6B, member RAS oncogene family)	protein interactions	270192	5	1	19454	50	BMPR1B
1.279e-02	-4.36	SUI2 (translation initiation factor eIF2 subunit alpha)	protein interactions	853463	5	1	19454	50	PRKCA
1.279e-02	-4.36	Rhobtb1 (Rho-related BTB domain containing 1)	protein interactions	69288	5	1	19454	50	BMPR1B
1.279e-02	-4.36	Rras2 (related RAS viral (r-ras) oncogene 2)	protein interactions	66922	5	1	19454	50	BMPR1B
1.279e-02	-4.36	GABRR2 (gamma-aminobutyric acid type A receptor subunit rho2)	protein interactions	2570	5	1	19454	50	PRKCA
1.279e-02	-4.36	TRPM6 (transient receptor potential cation channel subfamily M member 6)	protein interactions	140803	5	1	19454	50	TRPM3
1.279e-02	-4.36	Rab38 (RAB38, member RAS oncogene family)	protein interactions	72433	5	1	19454	50	BMPR1B
1.279e-02	-4.36	SLC10A3 (solute carrier family 10 member 3)	protein interactions	8273	5	1	19454	50	SORBS1
1.279e-02	-4.36	CFHR3 (complement factor H related 3)	protein interactions	10878	5	1	19454	50	PRKCA
1.279e-02	-4.36	Wwp2 (WW domain containing E3 ubiquitin protein ligase 2)	protein interactions	66894	5	1	19454	50	GLIS3
1.287e-02	-4.35	cranial nerve development	biological process	GO:0021545	64	2	18204	49	GLI3,SLC1A3
1.287e-02	-4.35	actin filament bundle assembly	biological process	GO:0051017	64	2	18204	49	SORBS1,FMN2
1.296e-02	-4.35	regulation of Wnt signaling pathway	biological process	GO:0030111	339	4	18204	49	CTNND2,MACF1,GPC5,GLI3
1.298e-02	-4.34	cGMP-PKG signaling pathway	KEGG pathways	hsa04022	163	3	7161	22	ITPR2,ADCY2,ATP1A2
1.298e-02	-4.34	cGMP-PKG signaling pathway	KEGG pathways	ko04022	163	3	7161	22	ITPR2,ATP1A2,ADCY2
1.302e-02	-4.34	pancreas-carcinoma	COSMIC cancer mutations	pancreas-carcinoma	14770	48	16828	49	BMPR1B,MACF1,CSGALNACT1,NEBL,ITPR2,ATP1A2,PRKCA,MAML2,NFIA,LSAMP,PTPRZ1,NKAIN3,FBXL7,SLC1A2,MGAT4C,NPAS3,TRPM3,GPM6A,PREX2,NTM,SLC1A3,TNIK,SOX5,NHSL1,SPARCL1,DST,PITPNC1,NTRK2,CDH20,ADCY2,DPP10,CTNND2,FMN2,SLC4A4,NRG3,TPD52L1,ZBTB20,GLIS3,RFX4,GLI3,RORA,GPC5,RYR3,PAMR1,SORBS1,ABLIM1,PARD3B,MSI2
1.304e-02	-4.34	SH3_9	pfam domains	PF14604	63	2	17795	49	NEBL,SORBS1
1.307e-02	-4.34	CTF_NFI_2	prosite domains	PS51080	4	1	12186	40	NFIA
1.307e-02	-4.34	CTF_NFI_1	prosite domains	PS00349	4	1	12186	40	NFIA
1.307e-02	-4.34	NEBULIN	prosite domains	PS51216	4	1	12186	40	NEBL
1.312e-02	-4.33	regulation of protein localization to membrane	biological process	GO:1905475	183	3	18204	49	GPC5,SORBS1,DPP10
1.320e-02	-4.33	transforming growth factor beta receptor activity, type I	molecular function	GO:0005025	5	1	18094	48	BMPR1B
1.320e-02	-4.33	neurotrophin receptor activity	molecular function	GO:0005030	5	1	18094	48	NTRK2
1.325e-02	-4.32	forebrain cell migration	biological process	GO:0021885	65	2	18204	49	NRG3,GLI3
1.327e-02	-4.32	L-amino acid transmembrane transporter activity	molecular function	GO:0015179	66	2	18094	48	SLC1A2,SLC1A3
1.328e-02	-4.32	positive regulation of multicellular organismal process	biological process	GO:0051240	1691	10	18204	49	BMPR1B,ZBTB20,ATP1A2,NTRK2,PRKCA,GLI3,SOX5,MACF1,RORA,PTPRZ1
1.330e-02	-4.32	cellular response to stimulus	biological process	GO:0051716	6307	25	18204	49	MAML2,ITPR2,ATP1A2,GLI3,RYR3,PITPNC1,DST,NRG3,RORA,SLC1A3,SPARCL1,NFIA,SLC1A2,PREX2,MACF1,BMPR1B,ZBTB20,DTNA,NTRK2,FMN2,PRKCA,CTNND2,TNIK,SORBS1,ADCY2
1.332e-02	-4.32	testis-germ_cell_tumour-non_seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-non_seminoma	487	5	16828	49	BMPR1B,NTRK2,PRKCA,TNIK,MACF1
1.332e-02	-4.32	human chr8q13.2	chromosome location	human chr8q13.2	7	1	26134	50	PREX2
1.339e-02	-4.31	negative regulation of chondrocyte proliferation	biological process	GO:1902731	5	1	18204	49	BMPR1B
1.339e-02	-4.31	amygdala development	biological process	GO:0021764	5	1	18204	49	ATP1A2
1.339e-02	-4.31	synaptic signaling via neuropeptide	biological process	GO:0099538	5	1	18204	49	NTRK2
1.339e-02	-4.31	polar body extrusion after meiotic divisions	biological process	GO:0040038	5	1	18204	49	FMN2
1.343e-02	-4.31	Follistatin/Osteonectin_EGF	interpro domains	IPR015369	5	1	18521	50	SPARCL1
1.343e-02	-4.31	Vinculin/catenin	interpro domains	IPR006077	5	1	18521	50	CTNNA2
1.343e-02	-4.31	PI_transfer	interpro domains	IPR001666	5	1	18521	50	PITPNC1
1.343e-02	-4.31	Na/HCO3_transpt	interpro domains	IPR003024	5	1	18521	50	SLC4A4
1.351e-02	-4.30	Ectoderm Differentiation	WikiPathways	WP2858	143	3	5310	19	GLI3,CTNNA2,CTNND2
1.352e-02	-4.30	NS-malignant_melanoma	COSMIC cancer mutations	NS-malignant_melanoma	3420	17	16828	49	PRKCA,ADCY2,ITPR2,ATP1A2,PITPNC1,MGAT4C,TRPM3,NEBL,GLIS3,RFX4,NRG3,PREX2,GPC5,PTPRZ1,CTNND2,MACF1,FMN2
1.364e-02	-4.29	L-alpha-amino acid transmembrane transport	biological process	GO:1902475	66	2	18204	49	SLC1A3,SLC1A2
1.367e-02	-4.29	neoplasm	COSMIC cancer mutations	neoplasm	14787	48	16828	49	SLC4A4,TPD52L1,NRG3,RFX4,GLIS3,ZBTB20,FMN2,DPP10,CTNND2,RORA,GLI3,SORBS1,DTNA,GPC5,RYR3,PAMR1,MSI2,PARD3B,ABLIM1,NEBL,BMPR1B,MACF1,CSGALNACT1,MAML2,NFIA,PRKCA,ATP1A2,ITPR2,GPM6A,PREX2,NTM,MGAT4C,NPAS3,TRPM3,NKAIN3,FBXL7,SLC1A2,LSAMP,PTPRZ1,ADCY2,NTRK2,CDH20,NHSL1,SPARCL1,DST,SLC1A3,TNIK,SOX5
1.369e-02	-4.29	Vinculin	pfam domains	PF01044	5	1	17795	49	CTNNA2
1.369e-02	-4.29	FOLN	pfam domains	PF09289	5	1	17795	49	SPARCL1
1.369e-02	-4.29	IP_trans	pfam domains	PF02121	5	1	17795	49	PITPNC1
1.376e-02	-4.29	Myh9 (myosin, heavy polypeptide 9, non-muscle)	protein interactions	17886	195	3	19454	50	ZBTB20,ABLIM1,DST
1.379e-02	-4.28	RAC1 (Rac family small GTPase 1)	protein interactions	5879	1005	7	19454	50	SLC1A3,PRKCA,DST,MACF1,PREX2,FMN2,DTNA
1.385e-02	-4.28	positive regulation of biological process	biological process	GO:0048518	6326	25	18204	49	DPP10,SLC4A4,BMPR1B,ZBTB20,PRKCA,SOX5,GLI3,ATP1A2,NTRK2,MAML2,FMN2,GPC5,SLC1A3,RORA,TNIK,NFIA,SORBS1,SLC1A2,GPM6A,RFX4,MACF1,PTPRZ1,NPAS3,GLIS3,TPD52L1
1.387e-02	-4.28	non_seminoma	COSMIC cancer mutations	non_seminoma	492	5	16828	49	TNIK,MACF1,PRKCA,NTRK2,BMPR1B
1.396e-02	-4.27	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-squamous_cell_carcinoma	9263	35	16828	49	FBXL7,NKAIN3,PAMR1,PTPRZ1,RYR3,LSAMP,GPC5,SORBS1,PREX2,TRPM3,MGAT4C,PITPNC1,DST,NHSL1,SOX5,TNIK,MSI2,ADCY2,CDH20,PARD3B,NTRK2,FMN2,CTNND2,MACF1,BMPR1B,GLIS3,NEBL,SLC4A4,ATP1A2,ITPR2,NFIA,MAML2,RORA,PRKCA,GLI3
1.399e-02	-4.27	PCDH20 (protocadherin 20)	protein interactions	64881	70	2	19454	50	MGAT4C,CTNNA2
1.402e-02	-4.27	NGF-independant TRKA activation	REACTOME pathways	R-HSA-187024	5	1	10285	29	NTRK2
1.402e-02	-4.27	Disinhibition of SNARE formation	REACTOME pathways	R-HSA-114516	5	1	10285	29	PRKCA
1.407e-02	-4.26	RAB35 (RAB35, member RAS oncogene family)	protein interactions	11021	559	5	19454	50	DTNA,FMN2,DST,MACF1,SLC1A3
1.418e-02	-4.26	liver-carcinoma-hepatocellular_carcinoma	COSMIC cancer mutations	liver-carcinoma-hepatocellular_carcinoma	14800	48	16828	49	GPC5,PAMR1,RYR3,SORBS1,DTNA,ABLIM1,PARD3B,FMN2,DPP10,CTNND2,SLC4A4,GLIS3,ZBTB20,RFX4,TPD52L1,NRG3,RORA,GLI3,NKAIN3,SLC1A2,FBXL7,LSAMP,PTPRZ1,NTM,GPM6A,PREX2,MGAT4C,TRPM3,NPAS3,SPARCL1,NHSL1,PITPNC1,DST,SLC1A3,SOX5,TNIK,ADCY2,NTRK2,CDH20,BMPR1B,CSGALNACT1,MACF1,NEBL,ATP1A2,ITPR2,MAML2,NFIA,PRKCA
1.418e-02	-4.26	hepatocellular_carcinoma	COSMIC cancer mutations	hepatocellular_carcinoma	14800	48	16828	49	SLC4A4,TPD52L1,NRG3,RFX4,ZBTB20,GLIS3,DPP10,CTNND2,FMN2,GLI3,RORA,DTNA,SORBS1,GPC5,RYR3,PAMR1,PARD3B,ABLIM1,NEBL,BMPR1B,MACF1,CSGALNACT1,PRKCA,MAML2,NFIA,ITPR2,ATP1A2,MGAT4C,NPAS3,TRPM3,GPM6A,PREX2,NTM,LSAMP,PTPRZ1,NKAIN3,FBXL7,SLC1A2,NTRK2,CDH20,ADCY2,SLC1A3,TNIK,SOX5,NHSL1,SPARCL1,DST,PITPNC1
1.432e-02	-4.25	Long-term depression	KEGG pathways	ko04730	60	2	7161	22	ITPR2,PRKCA
1.432e-02	-4.25	Long-term depression	KEGG pathways	hsa04730	60	2	7161	22	ITPR2,PRKCA
1.433e-02	-4.25	NEBU	smart domains	SM00227	4	1	9717	35	NEBL
1.435e-02	-4.24	small_intestine-carcinoid-endocrine_tumour	COSMIC cancer mutations	small_intestine-carcinoid-endocrine_tumour	175	3	16828	49	CSGALNACT1,TNIK,MACF1
1.437e-02	-4.24	AKR7L (aldo-keto reductase family 7 like (gene/pseudogene))	protein interactions	246181	71	2	19454	50	DST,MACF1
1.437e-02	-4.24	CRYBG1 (crystallin beta-gamma domain containing 1)	protein interactions	202	71	2	19454	50	CSGALNACT1,SPARCL1
1.437e-02	-4.24	ANK2 (ankyrin 2)	protein interactions	287	71	2	19454	50	TNIK,GPM6A
1.444e-02	-4.24	actin filament bundle organization	biological process	GO:0061572	68	2	18204	49	SORBS1,FMN2
1.446e-02	-4.24	Synaptic Vesicle Pathway	WikiPathways	WP2267	52	2	5310	19	ATP1A2,SLC1A3
1.446e-02	-4.24	ALPHACATENIN	prints domains	PR00805	4	1	5227	19	CTNNA2
1.448e-02	-4.24	skin-lower_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-lower_leg-malignant_melanoma-superficial_spreading	5	1	16828	49	PREX2
1.455e-02	-4.23	Corticotropin Activation of Cortisol Production	SMPDB pathways	SMP0000310	5	1	1369	4	ADCY2
1.455e-02	-4.23	Ion Channel and Phorbal Esters Signaling Pathway	SMPDB pathways	SMP0090032	5	1	1369	4	PRKCA
1.466e-02	-4.22	CH	pfam domains	PF00307	67	2	17795	49	MACF1,DST
1.476e-02	-4.22	PPP3CC (protein phosphatase 3 catalytic subunit gamma)	protein interactions	5533	72	2	19454	50	BMPR1B,PARD3B
1.476e-02	-4.22	DPYSL3 (dihydropyrimidinase like 3)	protein interactions	1809	72	2	19454	50	GPM6A,TNIK
1.480e-02	-4.21	cytoskeletal protein binding	molecular function	GO:0008092	989	7	18094	48	NEBL,ABLIM1,CTNNA2,MACF1,SORBS1,FMN2,DST
1.491e-02	-4.21	DBN1 (drebrin 1)	protein interactions	1627	370	4	19454	50	SOX5,PRKCA,ABLIM1,DST
1.500e-02	-4.20	adenoid_cystic_carcinoma	COSMIC cancer mutations	adenoid_cystic_carcinoma	1123	8	16828	49	RYR3,TNIK,CTNND2,PRKCA,NTRK2,MGAT4C,MAML2,RORA
1.509e-02	-4.19	cell surface receptor signaling pathway	biological process	GO:0007166	1992	11	18204	49	SORBS1,NFIA,MACF1,BMPR1B,NTRK2,MAML2,GLI3,CTNND2,DST,NRG3,TNIK
1.531e-02	-4.18	DPYSL2 (dihydropyrimidinase like 2)	protein interactions	1808	203	3	19454	50	TNIK,TPD52L1,GPM6A
1.532e-02	-4.18	ADCY1 (adenylate cyclase 1)	protein interactions	107	6	1	19454	50	ADCY2
1.532e-02	-4.18	Itch (itchy, E3 ubiquitin protein ligase)	protein interactions	16396	6	1	19454	50	GLIS3
1.532e-02	-4.18	Map2k3 (mitogen-activated protein kinase kinase 3)	protein interactions	26397	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SOX11 (SRY-box transcription factor 11)	protein interactions	6664	6	1	19454	50	SOX5
1.532e-02	-4.18	GDF6 (growth differentiation factor 6)	protein interactions	392255	6	1	19454	50	BMPR1B
1.532e-02	-4.18	SLC12A5 (solute carrier family 12 member 5)	protein interactions	57468	6	1	19454	50	GPM6A
1.532e-02	-4.18	ARMS2 (age-related maculopathy susceptibility 2)	protein interactions	387715	6	1	19454	50	PRKCA
1.532e-02	-4.18	SOX1 (SRY-box transcription factor 1)	protein interactions	6656	6	1	19454	50	SOX5
1.532e-02	-4.18	Zbtb2 (zinc finger and BTB domain containing 2)	protein interactions	381990	6	1	19454	50	SORBS1
1.532e-02	-4.18	Fancl (Fanconi anemia, complementation group L)	protein interactions	67030	6	1	19454	50	BMPR1B
1.532e-02	-4.18	Csnk1d (casein kinase 1, delta)	protein interactions	64462	6	1	19454	50	PRKCA
1.532e-02	-4.18	DRP2 (dystrophin related protein 2)	protein interactions	1821	6	1	19454	50	DTNA
1.532e-02	-4.18	CYRIA (CYFIP related Rac1 interactor A)	protein interactions	81553	6	1	19454	50	GPM6A
1.532e-02	-4.18	GPR135 (G protein-coupled receptor 135)	protein interactions	64582	6	1	19454	50	TPD52L1
1.532e-02	-4.18	Tiam2 (T cell lymphoma invasion and metastasis 2)	protein interactions	24001	6	1	19454	50	DTNA
1.532e-02	-4.18	Rhod (ras homolog family member D)	protein interactions	11854	6	1	19454	50	BMPR1B
1.546e-02	-4.17	Axon guidance	KEGG pathways	hsa04360	174	3	7161	22	PRKCA,BMPR1B,ABLIM1
1.546e-02	-4.17	Axon guidance	KEGG pathways	ko04360	174	3	7161	22	PRKCA,ABLIM1,BMPR1B
1.549e-02	-4.17	skin-ear-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-ear-carcinoma-squamous_cell_carcinoma	506	5	16828	49	DPP10,MGAT4C,NPAS3,SPARCL1,ZBTB20
1.550e-02	-4.17	LIM	pfam domains	PF00412	69	2	17795	49	ABLIM1,NEBL
1.552e-02	-4.17	CASK (calcium/calmodulin dependent serine protein kinase)	protein interactions	8573	204	3	19454	50	ABLIM1,DTNA,PARD3B
1.554e-02	-4.16	ErbB Signaling Pathway	WikiPathways	WP673	54	2	5310	19	PRKCA,NRG3
1.554e-02	-4.16	bone development	biological process	GO:0060348	195	3	18204	49	CSGALNACT1,BMPR1B,GLI3
1.576e-02	-4.15	Znf_LIM	interpro domains	IPR001781	71	2	18521	50	NEBL,ABLIM1
1.581e-02	-4.15	sodium:bicarbonate symporter activity	molecular function	GO:0008510	6	1	18094	48	SLC4A4
1.581e-02	-4.15	calcium-induced calcium release activity	molecular function	GO:0048763	6	1	18094	48	RYR3
1.581e-02	-4.15	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	molecular function	GO:0047238	6	1	18094	48	CSGALNACT1
1.581e-02	-4.15	steroid hormone binding	molecular function	GO:1990239	6	1	18094	48	ATP1A2
1.583e-02	-4.15	Neuronal System	REACTOME pathways	R-HSA-112316	349	4	10285	29	ADCY2,SLC1A3,PRKCA,SLC1A2
1.597e-02	-4.14	protein localization to plasma membrane	biological process	GO:0072659	197	3	18204	49	MACF1,DPP10,TNIK
1.600e-02	-4.13	other	COSMIC cancer mutations	other	14843	48	16828	49	PARD3B,MSI2,ABLIM1,DTNA,SORBS1,RYR3,PAMR1,GPC5,GLI3,RORA,TPD52L1,NRG3,RFX4,GLIS3,ZBTB20,SLC4A4,CTNND2,DPP10,FMN2,CDH20,NTRK2,ADCY2,TNIK,SOX5,SLC1A3,DST,NHSL1,SPARCL1,NPAS3,TRPM3,MGAT4C,GPM6A,PREX2,NTM,PTPRZ1,LSAMP,FBXL7,SLC1A2,NKAIN3,PRKCA,NFIA,MAML2,ITPR2,ATP1A2,NEBL,MACF1,CSGALNACT1,BMPR1B
1.604e-02	-4.13	gamma-aminobutyric acid biosynthetic process	biological process	GO:0009449	6	1	18204	49	SLC1A3
1.604e-02	-4.13	hemidesmosome assembly	biological process	GO:0031581	6	1	18204	49	DST
1.604e-02	-4.13	asymmetric neuroblast division	biological process	GO:0055059	6	1	18204	49	SOX5
1.604e-02	-4.13	fused antrum stage	biological process	GO:0048165	6	1	18204	49	BMPR1B
1.604e-02	-4.13	ERBB4-ERBB4 signaling pathway	biological process	GO:0038138	6	1	18204	49	NRG3
1.604e-02	-4.13	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	GO:0106071	6	1	18204	49	PRKCA
1.604e-02	-4.13	optic nerve morphogenesis	biological process	GO:0021631	6	1	18204	49	GLI3
1.604e-02	-4.13	establishment of meiotic spindle localization	biological process	GO:0051295	6	1	18204	49	FMN2
1.609e-02	-4.13	G3BP1 (G3BP stress granule assembly factor 1)	protein interactions	10146	799	6	19454	50	SOX5,MACF1,CTNNA2,DST,MSI2,SORBS1
1.609e-02	-4.13	EF-hand_dom_typ2	interpro domains	IPR015154	6	1	18521	50	DTNA
1.609e-02	-4.13	Glypican_CS	interpro domains	IPR019803	6	1	18521	50	GPC5
1.609e-02	-4.13	Glypican	interpro domains	IPR001863	6	1	18521	50	GPC5
1.609e-02	-4.13	P-type_ATPase_IIC	interpro domains	IPR005775	6	1	18521	50	ATP1A2
1.609e-02	-4.13	Adcy_conserved_dom	interpro domains	IPR009398	6	1	18521	50	ADCY2
1.609e-02	-4.13	Peptidase_S9B_N	interpro domains	IPR002469	6	1	18521	50	DPP10
1.609e-02	-4.13	EF-hand_dom_typ1	interpro domains	IPR015153	6	1	18521	50	DTNA
1.609e-02	-4.13	regulation of ATP metabolic process	biological process	GO:1903578	72	2	18204	49	SLC4A4,ZBTB20
1.616e-02	-4.13	bone-femur-other-chondroblastoma	COSMIC cancer mutations	bone-femur-other-chondroblastoma	183	3	16828	49	NRG3,RYR3,GPC5
1.622e-02	-4.12	salivary_gland	COSMIC cancer mutations	salivary_gland	1139	8	16828	49	RORA,MAML2,NTRK2,MGAT4C,PRKCA,RYR3,TNIK,CTNND2
1.627e-02	-4.12	protein-containing complex binding	molecular function	GO:0044877	1772	10	18094	48	DST,PTPRZ1,PRKCA,SPARCL1,MACF1,CTNNA2,ABLIM1,NFIA,NEBL,GLI3
1.627e-02	-4.12	sarcoplasmic reticulum	cellular component	GO:0016529	76	2	19108	49	RYR3,ITPR2
1.629e-02	-4.12	MKRN2 (makorin ring finger protein 2)	protein interactions	23609	380	4	19454	50	PRKCA,GLI3,MACF1,BMPR1B
1.629e-02	-4.12	Downstream signal transduction	REACTOME pathways	R-HSA-186763	352	4	10285	29	ADCY2,PRKCA,NRG3,ITPR2
1.641e-02	-4.11	Glypican	pfam domains	PF01153	6	1	17795	49	GPC5
1.641e-02	-4.11	EF-hand_3	pfam domains	PF09069	6	1	17795	49	DTNA
1.641e-02	-4.11	Adcy_cons_dom	pfam domains	PF06327	6	1	17795	49	ADCY2
1.641e-02	-4.11	DPPIV_N	pfam domains	PF00930	6	1	17795	49	DPP10
1.641e-02	-4.11	EF-hand_2	pfam domains	PF09068	6	1	17795	49	DTNA
1.652e-02	-4.10	neuron fate commitment	biological process	GO:0048663	73	2	18204	49	GLI3,NFIA
1.665e-02	-4.10	cytoskeleton	cellular component	GO:0005856	2412	12	19108	49	ABLIM1,TNIK,FMN2,DST,FBXL7,SORBS1,DTNA,MACF1,NEBL,PRKCA,CTNNA2,GLI3
1.673e-02	-4.09	axonogenesis	biological process	GO:0007409	366	4	18204	49	CTNNA2,BMPR1B,GLI3,PTPRZ1
1.675e-02	-4.09	skin-head_neck-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-head_neck-malignant_melanoma-superficial_spreading	923	7	16828	49	CTNND2,MACF1,PREX2,ADCY2,SORBS1,GLI3,MGAT4C
1.680e-02	-4.09	Activation of TRKA receptors	REACTOME pathways	R-HSA-187015	6	1	10285	29	NTRK2
1.691e-02	-4.08	DAP12 signaling	REACTOME pathways	R-HSA-2424491	356	4	10285	29	PRKCA,ADCY2,ITPR2,NRG3
1.695e-02	-4.08	positive regulation of protein localization to cell periphery	biological process	GO:1904377	74	2	18204	49	DPP10,SORBS1
1.709e-02	-4.07	human chr4q22.3	chromosome location	human chr4q22.3	9	1	26134	50	BMPR1B
1.716e-02	-4.07	MARCKS (myristoylated alanine rich protein kinase C substrate)	protein interactions	4082	588	5	19454	50	DTNA,ABLIM1,SLC1A3,PRKCA,MACF1
1.717e-02	-4.06	ATP2B3 (ATPase plasma membrane Ca2+ transporting 3)	protein interactions	492	78	2	19454	50	CSGALNACT1,GPM6A
1.717e-02	-4.06	ANKRD40 (ankyrin repeat domain 40)	protein interactions	91369	78	2	19454	50	MSI2,SOX5
1.717e-02	-4.06	Nedd4 (NEDD4 E3 ubiquitin protein ligase)	protein interactions	25489	78	2	19454	50	NTRK2,BMPR1B
1.722e-02	-4.06	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-squamous_cell_carcinoma	3507	17	16828	49	DPP10,GPC5,CTNND2,PTPRZ1,MACF1,RYR3,FMN2,TRPM3,NPAS3,SLC4A4,ZBTB20,PREX2,ATP1A2,DST,PARD3B,GLI3,ADCY2
1.729e-02	-4.06	RNF123 (ring finger protein 123)	protein interactions	63891	812	6	19454	50	DST,FMN2,CDH20,ITPR2,TRPM3,FBXL7
1.729e-02	-4.06	Dipeptidylpeptidase IV, N-terminal domain	gene3d domains	2.140.10.30	6	1	14470	42	DPP10
1.735e-02	-4.05	skin-forearm-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-forearm-malignant_melanoma-superficial_spreading	6	1	16828	49	PREX2
1.735e-02	-4.05	skin-head_neck-malignant_melanoma	COSMIC cancer mutations	skin-head_neck-malignant_melanoma	6	1	16828	49	PREX2
1.735e-02	-4.05	autonomic_ganglia-paraganglioma-benign	COSMIC cancer mutations	autonomic_ganglia-paraganglioma-benign	6	1	16828	49	NHSL1
1.744e-02	-4.05	Dopamine Activation of Neurological Reward System	SMPDB pathways	SMP0000308	6	1	1369	4	ADCY2
1.744e-02	-4.05	Intracellular Signalling Through PGD2 receptor and Prostaglandin D2	SMPDB pathways	SMP0000343	6	1	1369	4	ADCY2
1.744e-02	-4.05	Phospholipase C Signaling Pathway	SMPDB pathways	SMP0063783	6	1	1369	4	PRKCA
1.761e-02	-4.04	NCK1 (NCK adaptor protein 1)	protein interactions	4690	214	3	19454	50	NTRK2,TNIK,NHSL1
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	hsa04720	67	2	7161	22	ITPR2,PRKCA
1.766e-02	-4.04	Long-term potentiation	KEGG pathways	ko04720	67	2	7161	22	ITPR2,PRKCA
1.767e-02	-4.04	mannosyl-glycoprotein N-acetylglucosaminyltransferases	BIOCYC pathways	META_PWY-7426	8	1	902	2	MGAT4C
1.771e-02	-4.03	intracellular signal transduction	biological process	GO:0035556	1505	9	18204	49	ITPR2,ATP1A2,FMN2,PREX2,PRKCA,ADCY2,TNIK,NRG3,RYR3
1.782e-02	-4.03	alpha-beta T cell differentiation	biological process	GO:0046632	76	2	18204	49	GLI3,RORA
1.786e-02	-4.03	SLC16A5 (solute carrier family 16 member 5)	protein interactions	9121	7	1	19454	50	PTPRZ1
1.786e-02	-4.03	Fbxo3 (F-box protein 3)	protein interactions	57443	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smad7 (SMAD family member 7)	protein interactions	17131	7	1	19454	50	BMPR1B
1.786e-02	-4.03	Smurf1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	75788	7	1	19454	50	GLIS3
1.786e-02	-4.03	ZBTB45 (zinc finger and BTB domain containing 45)	protein interactions	84878	7	1	19454	50	ZBTB20
1.786e-02	-4.03	RGMB (repulsive guidance molecule BMP co-receptor b)	protein interactions	285704	7	1	19454	50	BMPR1B
1.786e-02	-4.03	ABCC12 (ATP binding cassette subfamily C member 12)	protein interactions	94160	7	1	19454	50	NPAS3
1.786e-02	-4.03	Uhmk1 (U2AF homology motif (UHM) kinase 1)	protein interactions	16589	7	1	19454	50	BMPR1B
1.786e-02	-4.03	SASH3 (SAM and SH3 domain containing 3)	protein interactions	54440	7	1	19454	50	BMPR1B
1.801e-02	-4.02	GJB1 (gap junction protein beta 1)	protein interactions	2705	80	2	19454	50	PRKCA,MSI2
1.805e-02	-4.01	NAHCO3TRSPRT	prints domains	PR01232	5	1	5227	19	SLC4A4
1.805e-02	-4.01	PITRANSFER	prints domains	PR00391	5	1	5227	19	PITPNC1
1.821e-02	-4.01	Signaling by EGFR	REACTOME pathways	R-HSA-177929	364	4	10285	29	ADCY2,PRKCA,NRG3,ITPR2
1.827e-02	-4.00	positive regulation of axonogenesis	biological process	GO:0050772	77	2	18204	49	MACF1,NTRK2
1.827e-02	-4.00	neural retina development	biological process	GO:0003407	77	2	18204	49	NTRK2,GPM6A
1.827e-02	-4.00	BMP signaling pathway	biological process	GO:0030509	77	2	18204	49	NFIA,BMPR1B
1.830e-02	-4.00	Glycosaminoglycan biosynthesis, chondroitin sulfate backbone	KEGG pathways	M00058	6	1	7161	22	CSGALNACT1
1.830e-02	-4.00	Glycosaminoglycan biosynthesis, chondroitin sulfate backbone	KEGG pathways	hsa_M00058	6	1	7161	22	CSGALNACT1
1.836e-02	-4.00	sarcomere	cellular component	GO:0030017	218	3	19108	49	DST,NEBL,RYR3
1.843e-02	-3.99	P-type sodium transporter activity	molecular function	GO:0008554	7	1	18094	48	ATP1A2
1.843e-02	-3.99	phosphatidic acid transfer activity	molecular function	GO:1990050	7	1	18094	48	PITPNC1
1.843e-02	-3.99	P-type sodium:potassium-exchanging transporter activity	molecular function	GO:0005391	7	1	18094	48	ATP1A2
1.844e-02	-3.99	regulation of neurogenesis	biological process	GO:0050767	377	4	18204	49	GLI3,PTPRZ1,NTRK2,MACF1
1.865e-02	-3.98	Protein_kinase_ATP_BS	interpro domains	IPR017441	377	4	18521	50	TNIK,PRKCA,NTRK2,BMPR1B
1.867e-02	-3.98	transmembrane transport	biological process	GO:0055085	1264	8	18204	49	ATP1A2,ITPR2,SLC1A2,SLC4A4,TRPM3,SLC1A3,RYR3,GPM6A
1.869e-02	-3.98	ventral spinal cord interneuron specification	biological process	GO:0021521	7	1	18204	49	GLI3
1.869e-02	-3.98	glial cell fate specification	biological process	GO:0021780	7	1	18204	49	NFIA
1.869e-02	-3.98	hindgut morphogenesis	biological process	GO:0007442	7	1	18204	49	GLI3
1.869e-02	-3.98	cell fate specification involved in pattern specification	biological process	GO:0060573	7	1	18204	49	GLI3
1.869e-02	-3.98	chromosome movement towards spindle pole	biological process	GO:0051305	7	1	18204	49	FMN2
1.869e-02	-3.98	parallel actin filament bundle assembly	biological process	GO:0030046	7	1	18204	49	FMN2
1.869e-02	-3.98	cellular response to magnesium ion	biological process	GO:0071286	7	1	18204	49	RYR3
1.869e-02	-3.98	negative regulation of Arp2/3 complex-mediated actin nucleation	biological process	GO:0034316	7	1	18204	49	CTNNA2
1.869e-02	-3.98	positive regulation of transcription of Notch receptor target	biological process	GO:0007221	7	1	18204	49	MAML2
1.869e-02	-3.98	interneuron migration from the subpallium to the cortex	biological process	GO:0021830	7	1	18204	49	NRG3
1.869e-02	-3.98	forebrain dorsal/ventral pattern formation	biological process	GO:0021798	7	1	18204	49	GLI3
1.869e-02	-3.98	regulation of oligodendrocyte progenitor proliferation	biological process	GO:0070445	7	1	18204	49	PTPRZ1
1.869e-02	-3.98	forebrain radial glial cell differentiation	biological process	GO:0021861	7	1	18204	49	GLI3
1.872e-02	-3.98	regulation of glucose transmembrane transport	biological process	GO:0010827	78	2	18204	49	SLC1A2,SORBS1
1.872e-02	-3.98	positive regulation of osteoblast differentiation	biological process	GO:0045669	78	2	18204	49	GLI3,BMPR1B
1.875e-02	-3.98	SPARC/Testican_Ca-bd-dom	interpro domains	IPR019577	7	1	18521	50	SPARCL1
1.875e-02	-3.98	GS_dom	interpro domains	IPR003605	7	1	18521	50	BMPR1B
1.875e-02	-3.98	Alpha-catenin/vinculin-like_sf	interpro domains	IPR036723	7	1	18521	50	CTNNA2
1.875e-02	-3.98	Plakophilin/d_Catenin	interpro domains	IPR028435	7	1	18521	50	CTNND2
1.886e-02	-3.97	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	WikiPathways	WP706	162	3	5310	19	SLC1A3,NTRK2,RORA
1.886e-02	-3.97	GSC (goosecoid homeobox)	protein interactions	145258	82	2	19454	50	NFIA,SOX5
1.897e-02	-3.96	human chr12p11.23	chromosome location	human chr12p11.23	10	1	26134	50	ITPR2
1.897e-02	-3.96	human chr9p24.2	chromosome location	human chr9p24.2	10	1	26134	50	GLIS3
1.898e-02	-3.96	Cysteine Rich Protein	gene3d domains	2.10.110.10	73	2	14470	42	NEBL,ABLIM1
1.902e-02	-3.96	testis	COSMIC cancer mutations	testis	733	6	16828	49	PREX2,NTRK2,PRKCA,BMPR1B,TNIK,MACF1
1.912e-02	-3.96	TGF_beta_GS	pfam domains	PF08515	7	1	17795	49	BMPR1B
1.912e-02	-3.96	SPARC_Ca_bdg	pfam domains	PF10591	7	1	17795	49	SPARCL1
1.920e-02	-3.95	EF_HAND_1	prosite domains	PS00018	174	3	12186	40	SPARCL1,DST,MACF1
1.921e-02	-3.95	caveola	cellular component	GO:0005901	83	2	19108	49	SORBS1,ATP1A2
1.939e-02	-3.94	DAP12 interactions	REACTOME pathways	R-HSA-2172127	371	4	10285	29	ITPR2,NRG3,PRKCA,ADCY2
1.942e-02	-3.94	cellular response to nitrogen compound	biological process	GO:1901699	580	5	18204	49	SORBS1,RYR3,SLC1A3,SLC1A2,ITPR2
1.954e-02	-3.94	GLYPICAN	prosite domains	PS01207	6	1	12186	40	GPC5
1.954e-02	-3.94	transmembrane receptor protein kinase activity	molecular function	GO:0019199	81	2	18094	48	BMPR1B,NTRK2
1.955e-02	-3.93	sensory organ development	biological process	GO:0007423	581	5	18204	49	NTRK2,GLI3,BMPR1B,GPM6A,NFIA
1.955e-02	-3.93	intracellular chemical homeostasis	biological process	GO:0055082	581	5	18204	49	RYR3,ZBTB20,SLC4A4,ATP1A2,SLC1A3
1.976e-02	-3.92	CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2)	protein interactions	830	403	4	19454	50	DST,ITPR2,MACF1,ABLIM1
2.009e-02	-3.91	adult locomotory behavior	biological process	GO:0008344	81	2	18204	49	PREX2,ATP1A2
2.020e-02	-3.90	SOX2 (SRY-box transcription factor 2)	protein interactions	6657	1342	8	19454	50	NFIA,LSAMP,SOX5,GLIS3,ITPR2,MSI2,GLI3,MACF1
2.021e-02	-3.90	CH_dom	interpro domains	IPR001715	81	2	18521	50	DST,MACF1
2.021e-02	-3.90	skin-upper_leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.021e-02	-3.90	skin-face-malignant_melanoma-nodular	COSMIC cancer mutations	skin-face-malignant_melanoma-nodular	7	1	16828	49	PREX2
2.023e-02	-3.90	Adherens junction	KEGG pathways	ko04520	72	2	7161	22	CTNNA2,SORBS1
2.023e-02	-3.90	Adherens junction	KEGG pathways	hsa04520	72	2	7161	22	CTNNA2,SORBS1
2.027e-02	-3.90	Signaling by PDGF	REACTOME pathways	R-HSA-186797	376	4	10285	29	PRKCA,ADCY2,ITPR2,NRG3
2.032e-02	-3.90	Vasopressin Regulation of Water Homeostasis	SMPDB pathways	SMP0000322	7	1	1369	4	ADCY2
2.032e-02	-3.90	g-Secretase Mediated ErbB4 Signalling Pathway	SMPDB pathways	SMP0089975	7	1	1369	4	PRKCA
2.034e-02	-3.90	HFE-transferrin receptor complex	cellular component	GO:1990712	8	1	19108	49	BMPR1B
2.034e-02	-3.90	zonula adherens	cellular component	GO:0005915	8	1	19108	49	SORBS1
2.034e-02	-3.90	hemidesmosome	cellular component	GO:0030056	8	1	19108	49	DST
2.038e-02	-3.89	BMP15 (bone morphogenetic protein 15)	protein interactions	9210	8	1	19454	50	BMPR1B
2.038e-02	-3.89	Rasd2 (RASD family, member 2)	protein interactions	75141	8	1	19454	50	BMPR1B
2.038e-02	-3.89	Mrps31 (mitochondrial ribosomal protein S31)	protein interactions	57312	8	1	19454	50	DST
2.038e-02	-3.89	Prkca (protein kinase C, alpha)	protein interactions	24680	8	1	19454	50	PRKCA
2.038e-02	-3.89	Marcks (myristoylated alanine rich protein kinase C substrate)	protein interactions	17118	8	1	19454	50	PRKCA
2.038e-02	-3.89	CD163 (CD163 molecule)	protein interactions	9332	8	1	19454	50	PRKCA
2.038e-02	-3.89	Rps27a (ribosomal protein S27A)	protein interactions	78294	8	1	19454	50	BMPR1B
2.038e-02	-3.89	INSM1 (INSM transcriptional repressor 1)	protein interactions	3642	8	1	19454	50	SORBS1
2.038e-02	-3.89	LHB (luteinizing hormone subunit beta)	protein interactions	3972	8	1	19454	50	NTM
2.049e-02	-3.89	Ion channel transport	REACTOME pathways	R-HSA-983712	209	3	10285	29	RYR3,TRPM3,ATP1A2
2.063e-02	-3.88	SYNJ1 (synaptojanin 1)	protein interactions	8867	86	2	19454	50	GPM6A,SORBS1
2.067e-02	-3.88	kidney-Wilms_tumour	COSMIC cancer mutations	kidney-Wilms_tumour	545	5	16828	49	NTRK2,BMPR1B,PRKCA,TNIK,FMN2
2.068e-02	-3.88	CH_dom_sf	interpro domains	IPR036872	82	2	18521	50	MACF1,DST
2.075e-02	-3.88	response to oxygen-containing compound	biological process	GO:1901700	1546	9	18204	49	SLC1A2,ATP1A2,ITPR2,ADCY2,ZBTB20,SORBS1,SLC1A3,RORA,RYR3
2.082e-02	-3.87	Wilms_tumour	COSMIC cancer mutations	Wilms_tumour	546	5	16828	49	PRKCA,TNIK,BMPR1B,NTRK2,FMN2
2.103e-02	-3.86	glutamate binding	molecular function	GO:0016595	8	1	18094	48	SLC1A3
2.103e-02	-3.86	P-type potassium transmembrane transporter activity	molecular function	GO:0008556	8	1	18094	48	ATP1A2
2.103e-02	-3.86	BMP receptor activity	molecular function	GO:0098821	8	1	18094	48	BMPR1B
2.103e-02	-3.86	sodium ion binding	molecular function	GO:0031402	8	1	18094	48	ATP1A2
2.106e-02	-3.86	eye-uveal_tract-malignant_melanoma-spindle	COSMIC cancer mutations	eye-uveal_tract-malignant_melanoma-spindle	363	4	16828	49	PREX2,CTNND2,TRPM3,MACF1
2.108e-02	-3.86	ZNF608 (zinc finger protein 608)	protein interactions	57507	87	2	19454	50	NFIA,SOX5
2.118e-02	-3.85	Regulation of insulin secretion	REACTOME pathways	R-HSA-422356	80	2	10285	29	PRKCA,ITPR2
2.123e-02	-3.85	H1-5 (H1.5 linker histone, cluster member)	protein interactions	3009	412	4	19454	50	PARD3B,PRKCA,MGAT4C,CSGALNACT1
2.126e-02	-3.85	femur	COSMIC cancer mutations	femur	1197	8	16828	49	GLI3,NRG3,ADCY2,SLC4A4,RYR3,PTPRZ1,GPC5,FMN2
2.127e-02	-3.85	DST (dystonin)	protein interactions	667	230	3	19454	50	TNIK,ATP1A2,NTRK2
2.130e-02	-3.85	leg	COSMIC cancer mutations	leg	969	7	16828	49	PTPRZ1,FMN2,NRG3,ZBTB20,NTM,SLC4A4,NEBL
2.134e-02	-3.85	regulation of synapse structural plasticity	biological process	GO:0051823	8	1	18204	49	CTNNA2
2.134e-02	-3.85	hindgut development	biological process	GO:0061525	8	1	18204	49	GLI3
2.134e-02	-3.85	ERBB4 signaling pathway	biological process	GO:0038130	8	1	18204	49	NRG3
2.134e-02	-3.85	cerebellar granule cell precursor proliferation	biological process	GO:0021930	8	1	18204	49	RORA
2.134e-02	-3.85	regulation of L-glutamate import across plasma membrane	biological process	GO:0002036	8	1	18204	49	ATP1A2
2.134e-02	-3.85	cell proliferation in external granule layer	biological process	GO:0021924	8	1	18204	49	RORA
2.134e-02	-3.85	dermatan sulfate proteoglycan biosynthetic process	biological process	GO:0050651	8	1	18204	49	CSGALNACT1
2.134e-02	-3.85	mitotic nuclear membrane disassembly	biological process	GO:0007077	8	1	18204	49	PRKCA
2.134e-02	-3.85	meiotic cytokinesis	biological process	GO:0033206	8	1	18204	49	FMN2
2.134e-02	-3.85	cell proliferation in hindbrain	biological process	GO:0021534	8	1	18204	49	RORA
2.134e-02	-3.85	gamma-aminobutyric acid metabolic process	biological process	GO:0009448	8	1	18204	49	SLC1A3
2.134e-02	-3.85	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	biological process	GO:0015014	8	1	18204	49	CSGALNACT1
2.140e-02	-3.84	TRPM_SLOG	interpro domains	IPR041491	8	1	18521	50	TRPM3
2.140e-02	-3.84	Chond_GalNAc	interpro domains	IPR008428	8	1	18521	50	CSGALNACT1
2.140e-02	-3.84	Adcy	interpro domains	IPR030672	8	1	18521	50	ADCY2
2.140e-02	-3.84	AC_N	interpro domains	IPR032628	8	1	18521	50	ADCY2
2.140e-02	-3.84	Villin_headpiece	interpro domains	IPR003128	8	1	18521	50	ABLIM1
2.140e-02	-3.84	Villin_headpiece_dom_sf	interpro domains	IPR036886	8	1	18521	50	ABLIM1
2.140e-02	-3.84	RFX-like	interpro domains	IPR039779	8	1	18521	50	RFX4
2.151e-02	-3.84	proteoglycan metabolic process	biological process	GO:0006029	84	2	18204	49	BMPR1B,CSGALNACT1
2.151e-02	-3.84	L-amino acid transport	biological process	GO:0015807	84	2	18204	49	SLC1A2,SLC1A3
2.151e-02	-3.84	regulation of sodium ion transport	biological process	GO:0002028	84	2	18204	49	NKAIN3,ATP1A2
2.153e-02	-3.84	HSPG2 (heparan sulfate proteoglycan 2)	protein interactions	3339	88	2	19454	50	GPC5,GLI3
2.153e-02	-3.84	RAP2A (RAP2A, member of RAS oncogene family)	protein interactions	5911	88	2	19454	50	TNIK,BMPR1B
2.162e-02	-3.83	ACTIVIN2R	prints domains	PR00653	6	1	5227	19	BMPR1B
2.177e-02	-3.83	cAMP signaling pathway	KEGG pathways	hsa04024	198	3	7161	22	GLI3,ATP1A2,ADCY2
2.177e-02	-3.83	cAMP signaling pathway	KEGG pathways	ko04024	198	3	7161	22	GLI3,ADCY2,ATP1A2
2.182e-02	-3.82	CHGN	pfam domains	PF05679	8	1	17795	49	CSGALNACT1
2.182e-02	-3.82	AC_N	pfam domains	PF16214	8	1	17795	49	ADCY2
2.182e-02	-3.82	VHP	pfam domains	PF02209	8	1	17795	49	ABLIM1
2.182e-02	-3.82	LSDAT_euk	pfam domains	PF18139	8	1	17795	49	TRPM3
2.186e-02	-3.82	skin-upper_arm-malignant_melanoma	COSMIC cancer mutations	skin-upper_arm-malignant_melanoma	553	5	16828	49	PARD3B,ITPR2,PREX2,SLC4A4,FMN2
2.199e-02	-3.82	regulation of smoothened signaling pathway	biological process	GO:0008589	85	2	18204	49	RORA,GLI3
2.201e-02	-3.82	-	gene3d domains	2.80.10.50	79	2	14470	42	ITPR2,RYR3
2.201e-02	-3.82	Calponin-like domain	gene3d domains	1.10.418.10	79	2	14470	42	MACF1,DST
2.201e-02	-3.82	organic anion transport	biological process	GO:0015711	398	4	18204	49	SLC4A4,NTRK2,SLC1A2,SLC1A3
2.207e-02	-3.81	Endochondral Ossification	WikiPathways	WP474	65	2	5310	19	GLI3,SOX5
2.215e-02	-3.81	Endothelins	Pathway Interaction DB	endothelinpathway	53	2	2226	10	ADCY2,PRKCA
2.224e-02	-3.81	HMG20A (high mobility group 20A)	protein interactions	10363	234	3	19454	50	SOX5,DTNA,NFIA
2.234e-02	-3.80	Release of Hh-Np from the secreting cell	REACTOME pathways	R-HSA-5362798	8	1	10285	29	GPC5
2.234e-02	-3.80	HuR (ELAVL1) binds and stabilizes mRNA	REACTOME pathways	R-HSA-450520	8	1	10285	29	PRKCA
2.246e-02	-3.80	CTDSPL (CTD small phosphatase like)	protein interactions	10217	90	2	19454	50	FMN2,DTNA
2.249e-02	-3.79	MARK3 (microtubule affinity regulating kinase 3)	protein interactions	4140	235	3	19454	50	NTRK2,MACF1,DTNA
2.264e-02	-3.79	LIM_DOMAIN_1	prosite domains	PS00478	71	2	12186	40	ABLIM1,NEBL
2.264e-02	-3.79	LIM_DOMAIN_2	prosite domains	PS50023	71	2	12186	40	NEBL,ABLIM1
2.276e-02	-3.78	GS	prosite domains	PS51256	7	1	12186	40	BMPR1B
2.285e-02	-3.78	platelet dense tubular network membrane	cellular component	GO:0031095	9	1	19108	49	ITPR2
2.285e-02	-3.78	flotillin complex	cellular component	GO:0016600	9	1	19108	49	SORBS1
2.290e-02	-3.78	VEPH1 (ventricular zone expressed PH domain containing 1)	protein interactions	79674	9	1	19454	50	BMPR1B
2.290e-02	-3.78	Tyw3 (tRNA-yW synthesizing protein 3 homolog (S. cerevisiae))	protein interactions	209584	9	1	19454	50	CTNNA2
2.290e-02	-3.78	SCTR (secretin receptor)	protein interactions	6344	9	1	19454	50	PRKCA
2.290e-02	-3.78	NRXN2 (neurexin 2)	protein interactions	9379	9	1	19454	50	MACF1
2.292e-02	-3.78	DGUOK (deoxyguanosine kinase)	protein interactions	1716	91	2	19454	50	GPM6A,NTM
2.292e-02	-3.78	SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)	protein interactions	6654	91	2	19454	50	TNIK,SORBS1
2.294e-02	-3.78	positive regulation of nucleobase-containing compound metabolic process	biological process	GO:0045935	2118	11	18204	49	RORA,ZBTB20,BMPR1B,SLC4A4,FMN2,MAML2,GLI3,RFX4,GLIS3,NPAS3,NFIA
2.296e-02	-3.77	dorsal/ventral pattern formation	biological process	GO:0009953	87	2	18204	49	GLI3,BMPR1B
2.299e-02	-3.77	CAMK2A (calcium/calmodulin dependent protein kinase II alpha)	protein interactions	815	237	3	19454	50	ITPR2,GPM6A,SOX5
2.299e-02	-3.77	Villin headpiece domain	gene3d domains	1.10.950.10	8	1	14470	42	ABLIM1
2.306e-02	-3.77	skin-chest-malignant_melanoma-nodular	COSMIC cancer mutations	skin-chest-malignant_melanoma-nodular	8	1	16828	49	PREX2
2.308e-02	-3.77	LAMP1 (lysosomal associated membrane protein 1)	protein interactions	3916	635	5	19454	50	TNIK,FMN2,MACF1,DST,SLC1A3
2.309e-02	-3.77	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	salivary_gland-parotid-carcinoma-adenoid_cystic_carcinoma	561	5	16828	49	MAML2,NTRK2,TNIK,PRKCA,RYR3
2.320e-02	-3.76	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin	SMPDB pathways	SMP0000354	8	1	1369	4	ADCY2
2.334e-02	-3.76	myofibril	cellular component	GO:0030016	239	3	19108	49	NEBL,RYR3,DST
2.341e-02	-3.75	CH	smart domains	SM00033	66	2	9717	35	DST,MACF1
2.363e-02	-3.75	calcium-dependent protein serine/threonine kinase activity	molecular function	GO:0009931	9	1	18094	48	PRKCA
2.381e-02	-3.74	cell leading edge	cellular component	GO:0031252	428	4	19108	49	MACF1,SLC1A2,ABLIM1,DST
2.381e-02	-3.74	collagen-containing extracellular matrix	cellular component	GO:0062023	428	4	19108	49	PTPRZ1,GPC5,DST,SPARCL1
2.384e-02	-3.74	DISC1 (DISC1 scaffold protein)	protein interactions	27185	427	4	19454	50	TNIK,SPARCL1,DST,MACF1
2.385e-02	-3.74	intermediate filament cytoskeleton	cellular component	GO:0045111	241	3	19108	49	MACF1,DTNA,DST
2.387e-02	-3.74	ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6)	protein interactions	9459	93	2	19454	50	ABLIM1,BMPR1B
2.395e-02	-3.73	cell fate specification	biological process	GO:0001708	89	2	18204	49	NFIA,GLI3
2.395e-02	-3.73	positive regulation of lipid biosynthetic process	biological process	GO:0046889	89	2	18204	49	ZBTB20,SORBS1
2.397e-02	-3.73	cranial suture morphogenesis	biological process	GO:0060363	9	1	18204	49	GLI3
2.397e-02	-3.73	embryonic neurocranium morphogenesis	biological process	GO:0048702	9	1	18204	49	GLI3
2.397e-02	-3.73	negative regulation of actin nucleation	biological process	GO:0051126	9	1	18204	49	CTNNA2
2.397e-02	-3.73	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	biological process	GO:0014808	9	1	18204	49	RYR3
2.397e-02	-3.73	negative regulation of striated muscle contraction	biological process	GO:0045988	9	1	18204	49	ATP1A2
2.397e-02	-3.73	semicircular canal development	biological process	GO:0060872	9	1	18204	49	GLI3
2.397e-02	-3.73	hindbrain radial glia guided cell migration	biological process	GO:0021932	9	1	18204	49	CTNNA2
2.401e-02	-3.73	ERBIN (erbb2 interacting protein)	protein interactions	55914	241	3	19454	50	DST,NTRK2,CTNND2
2.404e-02	-3.73	Activin_recp	interpro domains	IPR000472	9	1	18521	50	BMPR1B
2.404e-02	-3.73	Peptidase_S9	interpro domains	IPR001375	9	1	18521	50	DPP10
2.404e-02	-3.73	Fol_N	interpro domains	IPR003645	9	1	18521	50	SPARCL1
2.404e-02	-3.73	Band3_cytoplasmic_dom	interpro domains	IPR013769	9	1	18521	50	SLC4A4
2.404e-02	-3.73	DNA-bd_RFX	interpro domains	IPR003150	9	1	18521	50	RFX4
2.408e-02	-3.73	ion binding	molecular function	GO:0043167	6007	23	18094	48	RYR3,GLI3,ITPR2,CSGALNACT1,MACF1,DTNA,TNIK,SLC1A2,ADCY2,DST,ABLIM1,RORA,NTRK2,PRKCA,SLC1A3,PAMR1,GLIS3,MGAT4C,PITPNC1,ZBTB20,BMPR1B,ATP1A2,SPARCL1
2.411e-02	-3.73	intracellular signaling cassette	biological process	GO:0141124	837	6	18204	49	RYR3,ADCY2,ATP1A2,ITPR2,TNIK,PREX2
2.420e-02	-3.72	ACTG1 (actin gamma 1)	protein interactions	71	429	4	19454	50	ABLIM1,PRKCA,TNIK,FMN2
2.435e-02	-3.72	QSER1 (glutamine and serine rich 1)	protein interactions	79832	94	2	19454	50	SOX5,NFIA
2.435e-02	-3.72	FOXP4 (forkhead box P4)	protein interactions	116113	94	2	19454	50	NFIA,SOX5
2.435e-02	-3.72	TRAF3IP1 (TRAF3 interacting protein 1)	protein interactions	26146	94	2	19454	50	MACF1,DST
2.435e-02	-3.72	GRIN1 (glutamate ionotropic receptor NMDA type subunit 1)	protein interactions	2902	94	2	19454	50	PRKCA,NTRK2
2.438e-02	-3.71	postsynapse	cellular component	GO:0098794	646	5	19108	49	GPM6A,CTNND2,ATP1A2,NTRK2,TNIK
2.446e-02	-3.71	regulation of purine nucleotide metabolic process	biological process	GO:1900542	90	2	18204	49	ZBTB20,SLC4A4
2.452e-02	-3.71	Peptidase_S9	pfam domains	PF00326	9	1	17795	49	DPP10
2.452e-02	-3.71	RFX_DNA_binding	pfam domains	PF02257	9	1	17795	49	RFX4
2.452e-02	-3.71	Band_3_cyto	pfam domains	PF07565	9	1	17795	49	SLC4A4
2.452e-02	-3.71	Activin_recp	pfam domains	PF01064	9	1	17795	49	BMPR1B
2.459e-02	-3.71	human chr5p15.1	chromosome location	human chr5p15.1	13	1	26134	50	FBXL7
2.495e-02	-3.69	GS	smart domains	SM00467	7	1	9717	35	BMPR1B
2.496e-02	-3.69	regulation of nucleotide metabolic process	biological process	GO:0006140	91	2	18204	49	ZBTB20,SLC4A4
2.496e-02	-3.69	cellular response to BMP stimulus	biological process	GO:0071773	91	2	18204	49	NFIA,BMPR1B
2.496e-02	-3.69	response to BMP	biological process	GO:0071772	91	2	18204	49	BMPR1B,NFIA
2.496e-02	-3.69	DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	GO:0000981	1355	8	18094	48	SOX5,RFX4,NPAS3,RORA,NFIA,GLIS3,GLI3,ZBTB20
2.504e-02	-3.69	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-lymph_node-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	MAML2,TNIK,PRKCA,NTRK2
2.504e-02	-3.69	salivary_gland-carcinoma	COSMIC cancer mutations	salivary_gland-carcinoma	383	4	16828	49	PRKCA,TNIK,NTRK2,MAML2
2.504e-02	-3.69	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-head_neck-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	MAML2,PRKCA,TNIK,NTRK2
2.504e-02	-3.69	upper_aerodigestive_tract-carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-carcinoma	383	4	16828	49	MAML2,NTRK2,TNIK,PRKCA
2.504e-02	-3.69	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	COSMIC cancer mutations	upper_aerodigestive_tract-mouth-carcinoma-adenoid_cystic_carcinoma	383	4	16828	49	MAML2,TNIK,PRKCA,NTRK2
2.510e-02	-3.68	EGFR Transactivation by Gastrin	REACTOME pathways	R-HSA-2179392	9	1	10285	29	PRKCA
2.521e-02	-3.68	sarcoplasm	cellular component	GO:0016528	96	2	19108	49	ITPR2,RYR3
2.523e-02	-3.68	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-lymphoid_neoplasm-NK-T_cell_lymphoma	217	3	16828	49	DTNA,MGAT4C,RFX4
2.536e-02	-3.67	perineuronal net	cellular component	GO:0072534	10	1	19108	49	PTPRZ1
2.541e-02	-3.67	Vbp1 (von Hippel-Lindau binding protein 1)	protein interactions	22327	10	1	19454	50	ABLIM1
2.541e-02	-3.67	TNP1 (transition protein 1)	protein interactions	7141	10	1	19454	50	PRKCA
2.541e-02	-3.67	SLC8A2 (solute carrier family 8 member A2)	protein interactions	6543	10	1	19454	50	GPM6A
2.541e-02	-3.67	BANK1 (B cell scaffold protein with ankyrin repeats 1)	protein interactions	55024	10	1	19454	50	ITPR2
2.541e-02	-3.67	PPY (pancreatic polypeptide)	protein interactions	5539	10	1	19454	50	PRKCA
2.541e-02	-3.67	CALB2 (calbindin 2)	protein interactions	794	10	1	19454	50	GPM6A
2.541e-02	-3.67	Smurf2 (SMAD specific E3 ubiquitin protein ligase 2)	protein interactions	66313	10	1	19454	50	GLIS3
2.541e-02	-3.67	P2rx7 (purinergic receptor P2X 7)	protein interactions	29665	10	1	19454	50	PTPRZ1
2.541e-02	-3.67	GSG1 (germ cell associated 1)	protein interactions	83445	10	1	19454	50	PITPNC1
2.548e-02	-3.67	protein tetramerization	biological process	GO:0051262	92	2	18204	49	RYR3,TRPM3
2.568e-02	-3.66	spindle	COSMIC cancer mutations	spindle	386	4	16828	49	MACF1,CTNND2,TRPM3,PREX2
2.581e-02	-3.66	Tpm1 (tropomyosin 1, alpha)	protein interactions	22003	97	2	19454	50	ABLIM1,DST
2.585e-02	-3.66	NCOR2 (nuclear receptor corepressor 2)	protein interactions	9612	248	3	19454	50	SOX5,TNIK,NFIA
2.586e-02	-3.66	parotid	COSMIC cancer mutations	parotid	578	5	16828	49	MAML2,TNIK,PRKCA,RYR3,NTRK2
2.591e-02	-3.65	skin-upper_leg-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-upper_leg-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.591e-02	-3.65	skin-chest-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-chest-malignant_melanoma-superficial_spreading	9	1	16828	49	PREX2
2.595e-02	-3.65	contractile muscle fiber	cellular component	GO:0043292	249	3	19108	49	RYR3,DST,NEBL
2.597e-02	-3.65	HP	prosite domains	PS51089	8	1	12186	40	ABLIM1
2.599e-02	-3.65	enzyme-linked receptor protein signaling pathway	biological process	GO:0007167	626	5	18204	49	NRG3,NTRK2,NFIA,BMPR1B,SORBS1
2.599e-02	-3.65	intermediate filament cytoskeleton organization	biological process	GO:0045104	93	2	18204	49	DST,MACF1
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 7 and Serotonin	SMPDB pathways	SMP0000311	9	1	1369	4	ADCY2
2.607e-02	-3.65	Nitric Oxide Signaling Pathway	SMPDB pathways	SMP0063777	9	1	1369	4	PRKCA
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 6 and Serotonin	SMPDB pathways	SMP0000312	9	1	1369	4	ADCY2
2.607e-02	-3.65	Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone	SMPDB pathways	SMP0000333	9	1	1369	4	ADCY2
2.607e-02	-3.65	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin	SMPDB pathways	SMP0000309	9	1	1369	4	ADCY2
2.607e-02	-3.65	Intracellular Signalling Through Histamine H2 Receptor and Histamine	SMPDB pathways	SMP0000335	9	1	1369	4	ADCY2
2.616e-02	-3.64	muscle contraction	biological process	GO:0006936	238	3	18204	49	DTNA,RYR3,ATP1A2
2.616e-02	-3.64	protein localization to cell periphery	biological process	GO:1990778	238	3	18204	49	DPP10,MACF1,TNIK
2.618e-02	-3.64	axon development	biological process	GO:0061564	420	4	18204	49	GLI3,PTPRZ1,CTNNA2,BMPR1B
2.621e-02	-3.64	oesophagus-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-carcinoma-adenocarcinoma	13112	44	16828	49	RORA,GLI3,SLC4A4,GLIS3,RFX4,ZBTB20,TPD52L1,NRG3,FMN2,DPP10,CTNND2,PARD3B,SORBS1,GPC5,PAMR1,RYR3,MAML2,PRKCA,ATP1A2,ITPR2,NEBL,BMPR1B,CSGALNACT1,MACF1,ADCY2,NTRK2,CDH20,SPARCL1,NHSL1,DST,SLC1A3,SOX5,TNIK,NTM,PREX2,GPM6A,MGAT4C,TRPM3,NPAS3,NKAIN3,SLC1A2,FBXL7,LSAMP,PTPRZ1
2.622e-02	-3.64	neurotrophin binding	molecular function	GO:0043121	10	1	18094	48	NTRK2
2.622e-02	-3.64	phosphatidylinositol transfer activity	molecular function	GO:0008526	10	1	18094	48	PITPNC1
2.622e-02	-3.64	calcium-dependent protein kinase activity	molecular function	GO:0010857	10	1	18094	48	PRKCA
2.631e-02	-3.64	DNAAF2 (dynein axonemal assembly factor 2)	protein interactions	55172	98	2	19454	50	LSAMP,GPM6A
2.631e-02	-3.64	FRS2 (fibroblast growth factor receptor substrate 2)	protein interactions	10818	98	2	19454	50	SORBS1,NTRK2
2.645e-02	-3.63	dermatan sulfate biosynthesis	BIOCYC pathways	HUMAN_PWY-6571	12	1	902	2	CSGALNACT1
2.651e-02	-3.63	intermediate filament-based process	biological process	GO:0045103	94	2	18204	49	MACF1,DST
2.654e-02	-3.63	upper_arm	COSMIC cancer mutations	upper_arm	582	5	16828	49	ITPR2,PARD3B,PREX2,FMN2,SLC4A4
2.660e-02	-3.63	establishment of centrosome localization	biological process	GO:0051660	10	1	18204	49	PARD3B
2.660e-02	-3.63	desmosome organization	biological process	GO:0002934	10	1	18204	49	PRKCA
2.660e-02	-3.63	regulation of bone development	biological process	GO:1903010	10	1	18204	49	GLI3
2.660e-02	-3.63	retinal rod cell development	biological process	GO:0046548	10	1	18204	49	NTRK2
2.660e-02	-3.63	cAMP biosynthetic process	biological process	GO:0006171	10	1	18204	49	ADCY2
2.660e-02	-3.63	cellular response to brain-derived neurotrophic factor stimulus	biological process	GO:1990416	10	1	18204	49	NTRK2
2.660e-02	-3.63	trans-synaptic signaling, modulating synaptic transmission	biological process	GO:0099550	10	1	18204	49	NTRK2
2.660e-02	-3.63	substrate-independent telencephalic tangential migration	biological process	GO:0021826	10	1	18204	49	NRG3
2.660e-02	-3.63	spinal cord motor neuron cell fate specification	biological process	GO:0021520	10	1	18204	49	GLI3
2.660e-02	-3.63	regulation of mesenchymal stem cell differentiation	biological process	GO:2000739	10	1	18204	49	SOX5
2.660e-02	-3.63	positive regulation of lipopolysaccharide-mediated signaling pathway	biological process	GO:0031666	10	1	18204	49	PRKCA
2.660e-02	-3.63	substrate-independent telencephalic tangential interneuron migration	biological process	GO:0021843	10	1	18204	49	NRG3
2.660e-02	-3.63	negative regulation of glial cell apoptotic process	biological process	GO:0034351	10	1	18204	49	PRKCA
2.660e-02	-3.63	release of sequestered calcium ion into cytosol by endoplasmic reticulum	biological process	GO:1903514	10	1	18204	49	RYR3
2.666e-02	-3.62	Ig_sub2	interpro domains	IPR003598	239	3	18521	50	NTM,LSAMP,NTRK2
2.668e-02	-3.62	PAS_fold_3	interpro domains	IPR013655	10	1	18521	50	NPAS3
2.668e-02	-3.62	HCO3_transpt_euk	interpro domains	IPR003020	10	1	18521	50	SLC4A4
2.668e-02	-3.62	HCO3_transpt-like_TM_dom	interpro domains	IPR011531	10	1	18521	50	SLC4A4
2.668e-02	-3.62	PTrfase/Anion_transptr	interpro domains	IPR016152	10	1	18521	50	SLC4A4
2.682e-02	-3.62	LIM	smart domains	SM00132	71	2	9717	35	NEBL,ABLIM1
2.701e-02	-3.61	STX6 (syntaxin 6)	protein interactions	10228	444	4	19454	50	DTNA,DST,CSGALNACT1,MACF1
2.704e-02	-3.61	calcium ion transmembrane import into cytosol	biological process	GO:0097553	95	2	18204	49	RYR3,ITPR2
2.717e-02	-3.61	MYH9 (myosin heavy chain 9)	protein interactions	4627	663	5	19454	50	MACF1,DST,ITPR2,ABLIM1,ZBTB20
2.720e-02	-3.60	PAS_3	pfam domains	PF08447	10	1	17795	49	NPAS3
2.720e-02	-3.60	HCO3_cotransp	pfam domains	PF00955	10	1	17795	49	SLC4A4
2.731e-02	-3.60	SUFU (SUFU negative regulator of hedgehog signaling)	protein interactions	51684	100	2	19454	50	GLIS3,GLI3
2.731e-02	-3.60	ATP4A (ATPase H+/K+ transporting subunit alpha)	protein interactions	495	100	2	19454	50	GPM6A,ATP1A2
2.737e-02	-3.60	pancreas-other-adenoma	COSMIC cancer mutations	pancreas-other-adenoma	224	3	16828	49	CTNND2,PRKCA,BMPR1B
2.741e-02	-3.60	uveal_tract	COSMIC cancer mutations	uveal_tract	587	5	16828	49	MACF1,TRPM3,CTNND2,PREX2,ADCY2
2.748e-02	-3.59	Post-translational modification: synthesis of GPI-anchored proteins	REACTOME pathways	R-HSA-163125	92	2	10285	29	NTM,LSAMP
2.758e-02	-3.59	ErbB signaling pathway	KEGG pathways	ko04012	85	2	7161	22	PRKCA,NRG3
2.758e-02	-3.59	ErbB signaling pathway	KEGG pathways	hsa04012	85	2	7161	22	PRKCA,NRG3
2.769e-02	-3.59	NK-T_cell_lymphoma	COSMIC cancer mutations	NK-T_cell_lymphoma	225	3	16828	49	MGAT4C,DTNA,RFX4
2.780e-02	-3.58	intracellular monoatomic cation homeostasis	biological process	GO:0030003	428	4	18204	49	SLC1A3,ATP1A2,SLC4A4,RYR3
2.785e-02	-3.58	Bicarbonate transporters	REACTOME pathways	R-HSA-425381	10	1	10285	29	SLC4A4
2.785e-02	-3.58	Acetylcholine regulates insulin secretion	REACTOME pathways	R-HSA-399997	10	1	10285	29	PRKCA
2.785e-02	-3.58	PI3K events in ERBB4 signaling	REACTOME pathways	R-HSA-1250342	10	1	10285	29	NRG3
2.785e-02	-3.58	Adenylate cyclase activating pathway	REACTOME pathways	R-HSA-170660	10	1	10285	29	ADCY2
2.786e-02	-3.58	platelet dense tubular network	cellular component	GO:0031094	11	1	19108	49	ITPR2
2.786e-02	-3.58	perisynaptic extracellular matrix	cellular component	GO:0098966	11	1	19108	49	PTPRZ1
2.792e-02	-3.58	ITPKA (inositol-trisphosphate 3-kinase A)	protein interactions	3706	11	1	19454	50	PRKCA
2.792e-02	-3.58	Gtf2e2 (general transcription factor II E, polypeptide 2 (beta subunit))	protein interactions	68153	11	1	19454	50	NHSL1
2.792e-02	-3.58	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	protein interactions	74781	11	1	19454	50	MACF1
2.792e-02	-3.58	Cobll1 (Cobl-like 1)	protein interactions	319876	11	1	19454	50	ABLIM1
2.792e-02	-3.58	AQP5 (aquaporin 5)	protein interactions	362	11	1	19454	50	ATP1A2
2.792e-02	-3.58	Batf3 (basic leucine zipper transcription factor, ATF-like 3)	protein interactions	381319	11	1	19454	50	MACF1
2.792e-02	-3.58	IRAG1 (inositol 1,4,5-triphosphate receptor associated 1)	protein interactions	10335	11	1	19454	50	ITPR2
2.792e-02	-3.58	SYN3 (synapsin III)	protein interactions	8224	11	1	19454	50	GPM6A
2.792e-02	-3.58	TMEM53 (transmembrane protein 53)	protein interactions	79639	11	1	19454	50	PRKCA
2.802e-02	-3.58	RNA polymerase II transcription regulatory region sequence-specific DNA binding	molecular function	GO:0000977	1385	8	18094	48	GLIS3,GLI3,ZBTB20,RORA,NFIA,NPAS3,RFX4,SOX5
2.810e-02	-3.57	positive regulation of JNK cascade	biological process	GO:0046330	97	2	18204	49	TPD52L1,TNIK
2.810e-02	-3.57	nerve development	biological process	GO:0021675	97	2	18204	49	GLI3,SLC1A3
2.810e-02	-3.57	amino acid transmembrane transport	biological process	GO:0003333	97	2	18204	49	SLC1A2,SLC1A3
2.832e-02	-3.56	human chr8q12.3	chromosome location	human chr8q12.3	15	1	26134	50	NKAIN3
2.832e-02	-3.56	human chr10p12.31	chromosome location	human chr10p12.31	15	1	26134	50	NEBL
2.842e-02	-3.56	trans-synaptic signaling	biological process	GO:0099537	431	4	18204	49	DTNA,NTRK2,SLC1A2,SLC1A3
2.846e-02	-3.56	VHP	smart domains	SM00153	8	1	9717	35	ABLIM1
2.847e-02	-3.56	regulation of synapse organization	biological process	GO:0050807	246	3	18204	49	NTRK2,GPM6A,CTNNA2
2.865e-02	-3.55	HER-positive_carcinoma	COSMIC cancer mutations	HER-positive_carcinoma	2025	11	16828	49	GLI3,PRKCA,NTRK2,MSI2,MAML2,RORA,ABLIM1,NRG3,PAMR1,GPC5,BMPR1B
2.865e-02	-3.55	breast-carcinoma-HER-positive_carcinoma	COSMIC cancer mutations	breast-carcinoma-HER-positive_carcinoma	2025	11	16828	49	MSI2,NRG3,MAML2,RORA,PRKCA,GLI3,NTRK2,PAMR1,ABLIM1,GPC5,BMPR1B
2.866e-02	-3.55	Helical hairpin bin	gene3d domains	1.10.287.570	10	1	14470	42	SLC4A4
2.875e-02	-3.55	skin-back-malignant_melanoma-nodular	COSMIC cancer mutations	skin-back-malignant_melanoma-nodular	10	1	16828	49	PREX2
2.880e-02	-3.55	histone H3 kinase activity	molecular function	GO:0140996	11	1	18094	48	PRKCA
2.880e-02	-3.55	sulfur amino acid transmembrane transporter activity	molecular function	GO:0000099	11	1	18094	48	SLC1A2
2.884e-02	-3.55	CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2)	protein interactions	55454	103	2	19454	50	MGAT4C,CSGALNACT1
2.884e-02	-3.55	RAB6B (RAB6B, member RAS oncogene family)	protein interactions	51560	103	2	19454	50	GPM6A,BMPR1B
2.884e-02	-3.55	ID2 (inhibitor of DNA binding 2)	protein interactions	3398	103	2	19454	50	MACF1,DST
2.892e-02	-3.54	CH	prosite domains	PS50021	81	2	12186	40	MACF1,DST
2.893e-02	-3.54	amino acid transmembrane transporter activity	molecular function	GO:0015171	100	2	18094	48	SLC1A3,SLC1A2
2.893e-02	-3.54	Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin	SMPDB pathways	SMP0000338	10	1	1369	4	ADCY2
2.916e-02	-3.54	monoatomic ion channel activity	molecular function	GO:0005216	441	4	18094	48	GPM6A,ITPR2,TRPM3,RYR3
2.917e-02	-3.53	RFX_DBD	prosite domains	PS51526	9	1	12186	40	RFX4
2.922e-02	-3.53	cell fate commitment involved in pattern specification	biological process	GO:0060581	11	1	18204	49	GLI3
2.922e-02	-3.53	heparin biosynthetic process	biological process	GO:0030210	11	1	18204	49	CSGALNACT1
2.922e-02	-3.53	thymocyte apoptotic process	biological process	GO:0070242	11	1	18204	49	GLI3
2.922e-02	-3.53	establishment or maintenance of transmembrane electrochemical gradient	biological process	GO:0010248	11	1	18204	49	ATP1A2
2.922e-02	-3.53	glutamate secretion	biological process	GO:0014047	11	1	18204	49	NTRK2
2.922e-02	-3.53	ectodermal placode formation	biological process	GO:0060788	11	1	18204	49	NRG3
2.922e-02	-3.53	lactone metabolic process	biological process	GO:1901334	11	1	18204	49	ATP1A2
2.922e-02	-3.53	antral ovarian follicle growth	biological process	GO:0001547	11	1	18204	49	BMPR1B
2.922e-02	-3.53	cellular response to caffeine	biological process	GO:0071313	11	1	18204	49	RYR3
2.922e-02	-3.53	L-ascorbic acid metabolic process	biological process	GO:0019852	11	1	18204	49	ATP1A2
2.922e-02	-3.53	ectodermal placode morphogenesis	biological process	GO:0071697	11	1	18204	49	NRG3
2.922e-02	-3.53	negative regulation of neuron migration	biological process	GO:2001223	11	1	18204	49	NRG3
2.922e-02	-3.53	ventral spinal cord interneuron fate commitment	biological process	GO:0060579	11	1	18204	49	GLI3
2.929e-02	-3.53	EF-hand_7	pfam domains	PF13499	97	2	17795	49	MACF1,DST
2.931e-02	-3.53	Tyr_kinase_rcpt_2_CS	interpro domains	IPR002011	11	1	18521	50	NTRK2
2.936e-02	-3.53	CDH5 (cadherin 5)	protein interactions	1003	104	2	19454	50	CTNNA2,PRKCA
2.941e-02	-3.53	GABAergic synapse	KEGG pathways	ko04727	88	2	7161	22	PRKCA,ADCY2
2.941e-02	-3.53	GABAergic synapse	KEGG pathways	hsa04727	88	2	7161	22	PRKCA,ADCY2
2.970e-02	-3.52	intracellular monoatomic ion homeostasis	biological process	GO:0006873	437	4	18204	49	ATP1A2,SLC1A3,RYR3,SLC4A4
2.979e-02	-3.51	active transmembrane transporter activity	molecular function	GO:0022804	444	4	18094	48	SLC1A3,ATP1A2,SLC4A4,SLC1A2
3.021e-02	-3.50	response to organic substance	biological process	GO:0010033	2498	12	18204	49	SORBS1,ADCY2,SLC1A2,ZBTB20,ATP1A2,ITPR2,NTRK2,PRKCA,RYR3,TNIK,RORA,SLC1A3
3.026e-02	-3.50	Pathways in cancer	KEGG pathways	hsa05200	395	4	7161	22	PRKCA,CTNNA2,ADCY2,GLI3
3.027e-02	-3.50	regulation of glucose metabolic process	biological process	GO:0010906	101	2	18204	49	SORBS1,RORA
3.027e-02	-3.50	regulation of synapse structure or activity	biological process	GO:0050803	252	3	18204	49	NTRK2,CTNNA2,GPM6A
3.035e-02	-3.49	sodium:potassium-exchanging ATPase complex	cellular component	GO:0005890	12	1	19108	49	ATP1A2
3.035e-02	-3.49	synapse-associated extracellular matrix	cellular component	GO:0099535	12	1	19108	49	PTPRZ1
3.042e-02	-3.49	XK (X-linked Kx blood group antigen, Kell and VPS13A binding protein)	protein interactions	7504	12	1	19454	50	PRKCA
3.042e-02	-3.49	LMP-1 (latent membrane protein LMP-1)	protein interactions	3783750	12	1	19454	50	TNIK
3.042e-02	-3.49	ART4 (ADP-ribosyltransferase 4 (inactive) (Dombrock blood group))	protein interactions	420	12	1	19454	50	GPM6A
3.042e-02	-3.49	NTF4 (neurotrophin 4)	protein interactions	4909	12	1	19454	50	NTRK2
3.042e-02	-3.49	CA4 (carbonic anhydrase 4)	protein interactions	762	12	1	19454	50	SLC4A4
3.042e-02	-3.49	BAMBI (BMP and activin membrane bound inhibitor)	protein interactions	25805	12	1	19454	50	BMPR1B
3.042e-02	-3.49	Ctnnbl1 (catenin, beta like 1)	protein interactions	66642	12	1	19454	50	PRKCA
3.060e-02	-3.49	Type I hemidesmosome assembly	REACTOME pathways	R-HSA-446107	11	1	10285	29	DST
3.082e-02	-3.48	alpha-beta T cell activation	biological process	GO:0046631	102	2	18204	49	GLI3,RORA
3.083e-02	-3.48	response to stimulus	biological process	GO:0050896	7803	28	18204	49	GPM6A,ADCY2,SORBS1,CTNND2,TNIK,DTNA,CTNNA2,BMPR1B,ZBTB20,PRKCA,SOX5,NTRK2,FMN2,MACF1,NFIA,SPARCL1,SLC1A2,PREX2,DST,RYR3,PITPNC1,SLC1A3,NRG3,RORA,GLI3,ATP1A2,MAML2,ITPR2
3.087e-02	-3.48	eye	COSMIC cancer mutations	eye	606	5	16828	49	PREX2,ADCY2,MACF1,CTNND2,TRPM3
3.100e-02	-3.47	RHOA (ras homolog family member A)	protein interactions	387	1186	7	19454	50	MACF1,PREX2,ITPR2,PARD3B,CTNNA2,PRKCA,FMN2
3.101e-02	-3.47	regulation of neuron projection development	biological process	GO:0010975	443	4	18204	49	MACF1,CTNNA2,NTRK2,TNIK
3.107e-02	-3.47	MCAM (melanoma cell adhesion molecule)	protein interactions	4162	464	4	19454	50	TNIK,PARD3B,CTNNA2,DST
3.129e-02	-3.46	Morphine addiction	KEGG pathways	hsa05032	91	2	7161	22	ADCY2,PRKCA
3.129e-02	-3.46	Morphine addiction	KEGG pathways	ko05032	91	2	7161	22	ADCY2,PRKCA
3.138e-02	-3.46	regulation of neural precursor cell proliferation	biological process	GO:2000177	103	2	18204	49	GLI3,PTPRZ1
3.138e-02	-3.46	dipeptidyl-peptidase activity	molecular function	GO:0008239	12	1	18094	48	DPP10
3.138e-02	-3.46	adenylate cyclase binding	molecular function	GO:0008179	12	1	18094	48	ADCY2
3.138e-02	-3.46	inositol 1,4,5 trisphosphate binding	molecular function	GO:0070679	12	1	18094	48	ITPR2
3.147e-02	-3.46	DSG4 (desmoglein 4)	protein interactions	147409	108	2	19454	50	SPARCL1,CSGALNACT1
3.147e-02	-3.46	FKBP1A (FKBP prolyl isomerase 1A)	protein interactions	2280	108	2	19454	50	MSI2,RYR3
3.149e-02	-3.46	PFN1 (profilin 1)	protein interactions	5216	466	4	19454	50	FMN2,NHSL1,ABLIM1,MACF1
3.151e-02	-3.46	protein complex oligomerization	biological process	GO:0051259	256	3	18204	49	RYR3,TRPM3,SLC1A2
3.158e-02	-3.46	skin-hand-malignant_melanoma-acral_lentiginous	COSMIC cancer mutations	skin-hand-malignant_melanoma-acral_lentiginous	11	1	16828	49	PREX2
3.158e-02	-3.46	skin-back-malignant_melanoma-superficial_spreading	COSMIC cancer mutations	skin-back-malignant_melanoma-superficial_spreading	11	1	16828	49	PREX2
3.167e-02	-3.45	large_intestine-colon	COSMIC cancer mutations	large_intestine-colon	1291	8	16828	49	ADCY2,ZBTB20,PARD3B,GLI3,FMN2,DST,DPP10,PTPRZ1
3.177e-02	-3.45	Tgif disruption of Shh signaling	WikiPathways	WP3674	9	1	5310	19	GLI3
3.179e-02	-3.45	NAD+ Signalling and Aging	SMPDB pathways	SMP0084271	11	1	1369	4	RORA
3.182e-02	-3.45	cell fate commitment	biological process	GO:0045165	257	3	18204	49	NFIA,SOX5,GLI3
3.184e-02	-3.45	auditory behavior	biological process	GO:0031223	12	1	18204	49	SLC1A3
3.184e-02	-3.45	nuclear membrane disassembly	biological process	GO:0051081	12	1	18204	49	PRKCA
3.184e-02	-3.45	regulation of glial cell apoptotic process	biological process	GO:0034350	12	1	18204	49	PRKCA
3.184e-02	-3.45	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	biological process	GO:1902043	12	1	18204	49	BMPR1B
3.184e-02	-3.45	dermatan sulfate proteoglycan metabolic process	biological process	GO:0050655	12	1	18204	49	CSGALNACT1
3.184e-02	-3.45	mammalian oogenesis stage	biological process	GO:0022605	12	1	18204	49	BMPR1B
3.184e-02	-3.45	negative thymic T cell selection	biological process	GO:0045060	12	1	18204	49	GLI3
3.184e-02	-3.45	sulfur amino acid transport	biological process	GO:0000101	12	1	18204	49	SLC1A2
3.193e-02	-3.44	TGFB_receptor	interpro domains	IPR000333	12	1	18521	50	BMPR1B
3.193e-02	-3.44	MAD_homology1_Dwarfin-type	interpro domains	IPR003619	12	1	18521	50	NFIA
3.197e-02	-3.44	FOLN	smart domains	SM00274	9	1	9717	35	SPARCL1
3.200e-02	-3.44	PRR20A (proline rich 20A)	protein interactions	122183	109	2	19454	50	TRPM3,SOX5
3.200e-02	-3.44	CLSTN1 (calsyntenin 1)	protein interactions	22883	109	2	19454	50	MGAT4C,SLC1A3
3.204e-02	-3.44	human chr9q21.33	chromosome location	human chr9q21.33	17	1	26134	50	NTRK2
3.207e-02	-3.44	biliary_tract-bile_duct-carcinoma-adenocarcinoma	COSMIC cancer mutations	biliary_tract-bile_duct-carcinoma-adenocarcinoma	15095	48	16828	49	DTNA,SORBS1,GPC5,RYR3,PAMR1,PARD3B,MSI2,ABLIM1,SLC4A4,TPD52L1,NRG3,RFX4,GLIS3,ZBTB20,DPP10,CTNND2,FMN2,GLI3,RORA,MGAT4C,NPAS3,TRPM3,GPM6A,PREX2,NTM,LSAMP,PTPRZ1,FBXL7,SLC1A2,NTRK2,CDH20,ADCY2,SLC1A3,TNIK,SOX5,NHSL1,SPARCL1,DST,PITPNC1,NEBL,BMPR1B,MACF1,CSGALNACT1,PRKCA,MAML2,NFIA,ITPR2,ATP1A2
3.207e-02	-3.44	bile_duct	COSMIC cancer mutations	bile_duct	15095	48	16828	49	NEBL,BMPR1B,CSGALNACT1,MACF1,PRKCA,MAML2,NFIA,ITPR2,ATP1A2,MGAT4C,TRPM3,NPAS3,NTM,PREX2,GPM6A,LSAMP,PTPRZ1,SLC1A2,FBXL7,NTRK2,CDH20,ADCY2,SLC1A3,SOX5,TNIK,SPARCL1,NHSL1,PITPNC1,DST,SLC4A4,GLIS3,RFX4,ZBTB20,TPD52L1,NRG3,DPP10,CTNND2,FMN2,GLI3,RORA,DTNA,SORBS1,GPC5,PAMR1,RYR3,PARD3B,MSI2,ABLIM1
3.227e-02	-3.43	NAKATPASE	prints domains	PR00121	9	1	5227	19	ATP1A2
3.251e-02	-3.43	response to interleukin-1	biological process	GO:0070555	105	2	18204	49	RORA,PRKCA
3.251e-02	-3.43	cellular response to alcohol	biological process	GO:0097306	105	2	18204	49	ITPR2,ADCY2
3.251e-02	-3.43	positive regulation of protein localization to membrane	biological process	GO:1905477	105	2	18204	49	SORBS1,DPP10
3.251e-02	-3.43	gland morphogenesis	biological process	GO:0022612	105	2	18204	49	NRG3,GLI3
3.254e-02	-3.43	LZTR1 (leucine zipper like post translational regulator 1)	protein interactions	8216	110	2	19454	50	BMPR1B,PARD3B
3.256e-02	-3.42	SNCA (synuclein alpha)	protein interactions	6622	696	5	19454	50	NTRK2,MACF1,GPM6A,DST,TNIK
3.256e-02	-3.42	MH1	pfam domains	PF03165	12	1	17795	49	NFIA
3.264e-02	-3.42	Visual phototransduction	REACTOME pathways	R-HSA-2187338	101	2	10285	29	GPC5,PRKCA
3.264e-02	-3.42	Hedgehog 'off' state	REACTOME pathways	R-HSA-5610787	101	2	10285	29	ADCY2,GLI3
3.275e-02	-3.42	regulation of plasma membrane bounded cell projection organization	biological process	GO:0120035	666	5	18204	49	NTRK2,TNIK,MACF1,CTNNA2,GPM6A
3.276e-02	-3.42	steroid binding	molecular function	GO:0005496	107	2	18094	48	RORA,ATP1A2
3.291e-02	-3.41	Pias1 (protein inhibitor of activated STAT 1)	protein interactions	56469	13	1	19454	50	GLI3
3.291e-02	-3.41	IL23R (interleukin 23 receptor)	protein interactions	149233	13	1	19454	50	PRKCA
3.291e-02	-3.41	CEACAM16 (CEA cell adhesion molecule 16, tectorial membrane component)	protein interactions	388551	13	1	19454	50	DST
3.291e-02	-3.41	TBCC (tubulin folding cofactor C)	protein interactions	6903	13	1	19454	50	NTM
3.291e-02	-3.41	SPINK5 (serine peptidase inhibitor Kazal type 5)	protein interactions	11005	13	1	19454	50	CSGALNACT1
3.291e-02	-3.41	PCDHA2 (protocadherin alpha 2)	protein interactions	56146	13	1	19454	50	NFIA
3.291e-02	-3.41	RAB3C (RAB3C, member RAS oncogene family)	protein interactions	115827	13	1	19454	50	GPM6A
3.291e-02	-3.41	KCNQ2 (potassium voltage-gated channel subfamily Q member 2)	protein interactions	3785	13	1	19454	50	PRKCA
3.300e-02	-3.41	dermatan sulfate biosynthesis	BIOCYC pathways	META_PWY-6571	15	1	902	2	CSGALNACT1
3.307e-02	-3.41	oogenesis	biological process	GO:0048477	106	2	18204	49	FMN2,BMPR1B
3.330e-02	-3.40	Hedgehog signaling	KEGG pathways	hsa_M00678	11	1	7161	22	GLI3
3.330e-02	-3.40	Hedgehog signaling	KEGG pathways	M00678	11	1	7161	22	GLI3
3.333e-02	-3.40	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	REACTOME pathways	R-HSA-3656253	12	1	10285	29	GPC5
3.333e-02	-3.40	Defective EXT2 causes exostoses 2	REACTOME pathways	R-HSA-3656237	12	1	10285	29	GPC5
3.363e-02	-3.39	TBR1 (T-box brain transcription factor 1)	protein interactions	10716	112	2	19454	50	SOX5,NFIA
3.389e-02	-3.38	human chr18q21.33	chromosome location	human chr18q21.33	18	1	26134	50	CDH20
3.389e-02	-3.38	human chr7q31.32	chromosome location	human chr7q31.32	18	1	26134	50	PTPRZ1
3.395e-02	-3.38	monoatomic cation:bicarbonate symporter activity	molecular function	GO:0140410	13	1	18094	48	SLC4A4
3.395e-02	-3.38	transforming growth factor beta receptor activity	molecular function	GO:0005024	13	1	18094	48	BMPR1B
3.395e-02	-3.38	potassium ion binding	molecular function	GO:0030955	13	1	18094	48	ATP1A2
3.396e-02	-3.38	regulation of nervous system development	biological process	GO:0051960	456	4	18204	49	NTRK2,PTPRZ1,GLI3,MACF1
3.408e-02	-3.38	organic anion transmembrane transporter activity	molecular function	GO:0008514	268	3	18094	48	SLC1A3,SLC4A4,SLC1A2
3.425e-02	-3.37	ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17)	protein interactions	23390	277	3	19454	50	NEBL,GPM6A,SLC1A3
3.425e-02	-3.37	ACIN1 (apoptotic chromatin condensation inducer 1)	protein interactions	22985	277	3	19454	50	PRKCA,NFIA,CSGALNACT1
3.429e-02	-3.37	Alpha-catenin/vinculin-like	gene3d domains	1.20.120.230	12	1	14470	42	CTNNA2
3.432e-02	-3.37	PROTEIN_KINASE_ATP	prosite domains	PS00107	377	4	12186	40	PRKCA,TNIK,NTRK2,BMPR1B
3.439e-02	-3.37	regulation of canonical Wnt signaling pathway	biological process	GO:0060828	265	3	18204	49	GLI3,GPC5,CTNND2
3.439e-02	-3.37	ear	COSMIC cancer mutations	ear	624	5	16828	49	ZBTB20,SPARCL1,NPAS3,DPP10,MGAT4C
3.440e-02	-3.37	skin-abdomen-malignant_melanoma-nodular	COSMIC cancer mutations	skin-abdomen-malignant_melanoma-nodular	12	1	16828	49	PREX2
3.440e-02	-3.37	DNA-binding transcription factor activity	molecular function	GO:0003700	1441	8	18094	48	RFX4,NPAS3,SOX5,GLIS3,GLI3,ZBTB20,RORA,NFIA
3.444e-02	-3.37	Stimuli-sensing channels	REACTOME pathways	R-HSA-2672351	104	2	10285	29	RYR3,TRPM3
3.444e-02	-3.37	cerebellar Purkinje cell differentiation	biological process	GO:0021702	13	1	18204	49	RORA
3.444e-02	-3.37	negative regulation of cytosolic calcium ion concentration	biological process	GO:0051481	13	1	18204	49	ATP1A2
3.444e-02	-3.37	prepulse inhibition	biological process	GO:0060134	13	1	18204	49	CTNNA2
3.444e-02	-3.37	membrane disassembly	biological process	GO:0030397	13	1	18204	49	PRKCA
3.444e-02	-3.37	ventral spinal cord interneuron differentiation	biological process	GO:0021514	13	1	18204	49	GLI3
3.444e-02	-3.37	regulation of respiratory gaseous exchange by nervous system process	biological process	GO:0002087	13	1	18204	49	ATP1A2
3.444e-02	-3.37	negative T cell selection	biological process	GO:0043383	13	1	18204	49	GLI3
3.444e-02	-3.37	glial cell fate commitment	biological process	GO:0021781	13	1	18204	49	NFIA
3.444e-02	-3.37	ectodermal placode development	biological process	GO:0071696	13	1	18204	49	NRG3
3.444e-02	-3.37	T-helper 17 cell differentiation	biological process	GO:0072539	13	1	18204	49	RORA
3.459e-02	-3.36	plasma membrane raft	cellular component	GO:0044853	114	2	19108	49	SORBS1,ATP1A2
3.459e-02	-3.36	small molecule binding	molecular function	GO:0036094	6197	23	18094	48	TNIK,ADCY2,SLC1A2,DTNA,CSGALNACT1,MACF1,DST,NTRK2,ABLIM1,RORA,RYR3,GLI3,ITPR2,ATP1A2,BMPR1B,SPARCL1,SLC1A3,PRKCA,ZBTB20,PITPNC1,MGAT4C,GLIS3,PAMR1
3.464e-02	-3.36	Lactose Intolerance	SMPDB pathways	SMP0000458	12	1	1369	4	ATP1A2
3.464e-02	-3.36	Lactose Degradation	SMPDB pathways	SMP0000457	12	1	1369	4	ATP1A2
3.466e-02	-3.36	synaptic signaling	biological process	GO:0099536	459	4	18204	49	NTRK2,SLC1A2,SLC1A3,DTNA
3.474e-02	-3.36	ORF3b (ORF3b protein)	protein interactions	1489670	114	2	19454	50	MACF1,ZBTB20
3.481e-02	-3.36	regulation of protein localization to plasma membrane	biological process	GO:1903076	109	2	18204	49	SORBS1,DPP10
3.487e-02	-3.36	RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	GO:0000978	1180	7	18094	48	RFX4,SOX5,GLI3,GLIS3,ZBTB20,RORA,NFIA
3.506e-02	-3.35	chemical homeostasis	biological process	GO:0048878	914	6	18204	49	ZBTB20,SLC4A4,ATP1A2,RYR3,RORA,SLC1A3
3.518e-02	-3.35	chondroitin sulfate biosynthesis	BIOCYC pathways	HUMAN_PWY-6569	16	1	902	2	CSGALNACT1
3.518e-02	-3.35	Phosphatidylinositol signaling system	KEGG pathways	hsa04070	97	2	7161	22	PRKCA,ITPR2
3.518e-02	-3.35	Phosphatidylinositol signaling system	KEGG pathways	ko04070	97	2	7161	22	ITPR2,PRKCA
3.522e-02	-3.35	response to organonitrogen compound	biological process	GO:0010243	915	6	18204	49	SLC1A2,TNIK,ITPR2,SLC1A3,SORBS1,RYR3
3.527e-02	-3.34	VEGFR2 mediated cell proliferation	REACTOME pathways	R-HSA-5218921	258	3	10285	29	NRG3,ITPR2,PRKCA
3.530e-02	-3.34	SMAD7 (SMAD family member 7)	protein interactions	4092	115	2	19454	50	BMPR1B,SOX5
3.540e-02	-3.34	MB (myoglobin)	protein interactions	4151	14	1	19454	50	MAML2
3.540e-02	-3.34	DACT2 (dishevelled binding antagonist of beta catenin 2)	protein interactions	168002	14	1	19454	50	ZBTB20
3.540e-02	-3.34	Tecpr2 (tectonin beta-propeller repeat containing 2)	protein interactions	104859	14	1	19454	50	DST
3.540e-02	-3.34	Nedd4 (neural precursor cell expressed, developmentally down-regulated 4)	protein interactions	17999	14	1	19454	50	GLIS3
3.540e-02	-3.34	Asap1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain1)	protein interactions	13196	14	1	19454	50	MACF1
3.540e-02	-3.34	CHAT (choline O-acetyltransferase)	protein interactions	1103	14	1	19454	50	PRKCA
3.540e-02	-3.34	AZIN2 (antizyme inhibitor 2)	protein interactions	113451	14	1	19454	50	TPD52L1
3.540e-02	-3.34	TAS2R7 (taste 2 receptor member 7)	protein interactions	50837	14	1	19454	50	PRKCA
3.540e-02	-3.34	BOD1L2 (biorientation of chromosomes in cell division 1 like 2)	protein interactions	284257	14	1	19454	50	FMN2
3.540e-02	-3.34	PLXNA4 (plexin A4)	protein interactions	91584	14	1	19454	50	GPM6A
3.540e-02	-3.34	RHEBL1 (RHEB like 1)	protein interactions	121268	14	1	19454	50	BMPR1B
3.540e-02	-3.34	SLC1A2 (solute carrier family 1 member 2)	protein interactions	6506	14	1	19454	50	SLC1A2
3.553e-02	-3.34	RECEPTOR_TYR_KIN_II	prosite domains	PS00239	11	1	12186	40	NTRK2
3.573e-02	-3.33	positive regulation of cellular metabolic process	biological process	GO:0031325	3164	14	18204	49	RORA,TNIK,GLI3,MAML2,NTRK2,SLC4A4,BMPR1B,ZBTB20,NPAS3,GLIS3,TPD52L1,RFX4,NFIA,SORBS1
3.574e-02	-3.33	human chr6q24.1	chromosome location	human chr6q24.1	19	1	26134	50	NHSL1
3.574e-02	-3.33	human chr5p15.2	chromosome location	human chr5p15.2	19	1	26134	50	CTNND2
3.574e-02	-3.33	human chr11q25	chromosome location	human chr11q25	19	1	26134	50	NTM
3.575e-02	-3.33	large_cell_carcinoma	COSMIC cancer mutations	large_cell_carcinoma	849	6	16828	49	PRKCA,NTRK2,TNIK,PTPRZ1,DPP10,BMPR1B
3.575e-02	-3.33	lung-carcinoma-large_cell_carcinoma	COSMIC cancer mutations	lung-carcinoma-large_cell_carcinoma	849	6	16828	49	BMPR1B,DPP10,PTPRZ1,TNIK,NTRK2,PRKCA
3.577e-02	-3.33	SH3DOMAIN	prints domains	PR00452	83	2	5227	19	SORBS1,NEBL
3.579e-02	-3.33	HCO3TRNSPORT	prints domains	PR01231	10	1	5227	19	SLC4A4
3.585e-02	-3.33	Estrogen signaling pathway	KEGG pathways	hsa04915	98	2	7161	22	ADCY2,ITPR2
3.585e-02	-3.33	Estrogen signaling pathway	KEGG pathways	ko04915	98	2	7161	22	ADCY2,ITPR2
3.586e-02	-3.33	SKIL (SKI like proto-oncogene)	protein interactions	6498	116	2	19454	50	MACF1,SPARCL1
3.593e-02	-3.33	regulation of cell projection organization	biological process	GO:0031344	683	5	18204	49	NTRK2,TNIK,CTNNA2,GPM6A,MACF1
3.604e-02	-3.32	rhythmic process	biological process	GO:0048511	270	3	18204	49	BMPR1B,RORA,NTRK2
3.606e-02	-3.32	ERBB2 Activates PTK6 Signaling	REACTOME pathways	R-HSA-8847993	13	1	10285	29	NRG3
3.606e-02	-3.32	NOTCH2 intracellular domain regulates transcription	REACTOME pathways	R-HSA-2197563	13	1	10285	29	MAML2
3.606e-02	-3.32	CLEC7A (Dectin-1) induces NFAT activation	REACTOME pathways	R-HSA-5607763	13	1	10285	29	ITPR2
3.606e-02	-3.32	Notch-HLH transcription pathway	REACTOME pathways	R-HSA-350054	13	1	10285	29	MAML2
3.612e-02	-3.32	kidney-carcinoma-chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	kidney-carcinoma-chromophobe_renal_cell_carcinoma	430	4	16828	49	PRKCA,TNIK,BMPR1B,NTRK2
3.612e-02	-3.32	chromophobe_renal_cell_carcinoma	COSMIC cancer mutations	chromophobe_renal_cell_carcinoma	430	4	16828	49	PRKCA,TNIK,BMPR1B,NTRK2
3.612e-02	-3.32	oesophagus-lower_third-carcinoma-adenocarcinoma	COSMIC cancer mutations	oesophagus-lower_third-carcinoma-adenocarcinoma	6302	25	16828	49	DPP10,CTNND2,MACF1,FMN2,NEBL,ZBTB20,NRG3,ITPR2,PRKCA,GLI3,RORA,GPC5,PTPRZ1,PAMR1,RYR3,MGAT4C,TRPM3,NPAS3,PREX2,SORBS1,SOX5,NTRK2,PARD3B,CDH20,ADCY2
3.647e-02	-3.31	phosphorus metabolic process	biological process	GO:0006793	1707	9	18204	49	PTPRZ1,TNIK,RORA,CSGALNACT1,PRKCA,NTRK2,ATP1A2,ADCY2,BMPR1B
3.652e-02	-3.31	microtubule minus-end binding	molecular function	GO:0051011	14	1	18094	48	MACF1
3.670e-02	-3.31	phosphatidylinositol binding	molecular function	GO:0035091	276	3	18094	48	ITPR2,PARD3B,PITPNC1
3.699e-02	-3.30	DNM1 (dynamin 1)	protein interactions	1759	118	2	19454	50	GPM6A,PRKCA
3.699e-02	-3.30	TTC3 (tetratricopeptide repeat domain 3)	protein interactions	7267	118	2	19454	50	SPARCL1,DST
3.699e-02	-3.30	VSIG8 (V-set and immunoglobulin domain containing 8)	protein interactions	391123	118	2	19454	50	CSGALNACT1,SPARCL1
3.704e-02	-3.30	layer formation in cerebral cortex	biological process	GO:0021819	14	1	18204	49	GLI3
3.704e-02	-3.30	cellular response to purine-containing compound	biological process	GO:0071415	14	1	18204	49	RYR3
3.704e-02	-3.30	radial glial cell differentiation	biological process	GO:0060019	14	1	18204	49	GLI3
3.704e-02	-3.30	relaxation of cardiac muscle	biological process	GO:0055119	14	1	18204	49	ATP1A2
3.704e-02	-3.30	mechanosensory behavior	biological process	GO:0007638	14	1	18204	49	SLC1A3
3.704e-02	-3.30	response to forskolin	biological process	GO:1904321	14	1	18204	49	ADCY2
3.704e-02	-3.30	negative regulation of sodium ion transmembrane transporter activity	biological process	GO:2000650	14	1	18204	49	ATP1A2
3.704e-02	-3.30	cellular response to ethanol	biological process	GO:0071361	14	1	18204	49	ITPR2
3.704e-02	-3.30	glutathione biosynthetic process	biological process	GO:0006750	14	1	18204	49	SLC1A2
3.704e-02	-3.30	cellular response to forskolin	biological process	GO:1904322	14	1	18204	49	ADCY2
3.709e-02	-3.29	cellular homeostasis	biological process	GO:0019725	689	5	18204	49	SLC1A3,ATP1A2,SLC4A4,ZBTB20,RYR3
3.721e-02	-3.29	skin-scalp-malignant_melanoma-nodular	COSMIC cancer mutations	skin-scalp-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.721e-02	-3.29	skin-shoulder-malignant_melanoma-nodular	COSMIC cancer mutations	skin-shoulder-malignant_melanoma-nodular	13	1	16828	49	PREX2
3.749e-02	-3.28	Trehalose Degradation	SMPDB pathways	SMP0000467	13	1	1369	4	ATP1A2
3.749e-02	-3.28	Succinate Signalling During Inflammation	SMPDB pathways	SMP0084634	13	1	1369	4	PRKCA
3.750e-02	-3.28	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	COSMIC cancer mutations	central_nervous_system-cerebellum-glioma-astrocytoma_Grade_I	105	2	16828	49	GPC5,NRG3
3.754e-02	-3.28	basal plasma membrane	cellular component	GO:0009925	288	3	19108	49	SLC1A3,SLC4A4,DST
3.754e-02	-3.28	cellular response to organic substance	biological process	GO:0071310	1716	9	18204	49	SLC1A2,ITPR2,ATP1A2,ADCY2,ZBTB20,SORBS1,SLC1A3,RORA,RYR3
3.756e-02	-3.28	ITGB4 (integrin subunit beta 4)	protein interactions	3691	119	2	19454	50	DST,PRKCA
3.780e-02	-3.28	axolemma	cellular component	GO:0030673	15	1	19108	49	SLC1A2
3.788e-02	-3.27	XIRP1 (xin actin binding repeat containing 1)	protein interactions	165904	15	1	19454	50	NEBL
3.788e-02	-3.27	FN3K (fructosamine 3 kinase)	protein interactions	64122	15	1	19454	50	PRKCA
3.788e-02	-3.27	IGSF1 (immunoglobulin superfamily member 1)	protein interactions	3547	15	1	19454	50	BMPR1B
3.788e-02	-3.27	TIAM2 (TIAM Rac1 associated GEF 2)	protein interactions	26230	15	1	19454	50	TNIK
3.788e-02	-3.27	TESPA1 (thymocyte expressed, positive selection associated 1)	protein interactions	9840	15	1	19454	50	ITPR2
3.788e-02	-3.27	GRM7 (glutamate metabotropic receptor 7)	protein interactions	2917	15	1	19454	50	PRKCA
3.788e-02	-3.27	TAFA5 (TAFA chemokine like family member 5)	protein interactions	25817	15	1	19454	50	NEBL
3.788e-02	-3.27	ADRA1B (adrenoceptor alpha 1B)	protein interactions	147	15	1	19454	50	PRKCA
3.788e-02	-3.27	PCSK1N (proprotein convertase subtilisin/kexin type 1 inhibitor)	protein interactions	27344	15	1	19454	50	MGAT4C
3.788e-02	-3.27	OGG1 (8-oxoguanine DNA glycosylase)	protein interactions	4968	15	1	19454	50	PRKCA
3.788e-02	-3.27	ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive))	protein interactions	957	15	1	19454	50	PRKCA
3.788e-02	-3.27	Melanogenesis	KEGG pathways	hsa04916	101	2	7161	22	PRKCA,ADCY2
3.788e-02	-3.27	Melanogenesis	KEGG pathways	ko04916	101	2	7161	22	ADCY2,PRKCA
3.806e-02	-3.27	positive regulation of MAPK cascade	biological process	GO:0043410	473	4	18204	49	PRKCA,TPD52L1,NTRK2,TNIK
3.808e-02	-3.27	learning or memory	biological process	GO:0007611	276	3	18204	49	ATP1A2,NTRK2,PTPRZ1
3.810e-02	-3.27	CEP128 (centrosomal protein 128)	protein interactions	145508	289	3	19454	50	NEBL,ABLIM1,SORBS1
3.814e-02	-3.27	cis-regulatory region sequence-specific DNA binding	molecular function	GO:0000987	1203	7	18094	48	ZBTB20,GLIS3,GLI3,NFIA,RORA,RFX4,SOX5
3.843e-02	-3.26	BCOR (BCL6 corepressor)	protein interactions	54880	290	3	19454	50	SOX5,GLI3,NFIA
3.851e-02	-3.26	stomach-carcinoma	COSMIC cancer mutations	stomach-carcinoma	439	4	16828	49	TNIK,PRKCA,NTRK2,BMPR1B
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	ko04922	102	2	7161	22	ADCY2,ITPR2
3.857e-02	-3.26	Glucagon signaling pathway	KEGG pathways	hsa04922	102	2	7161	22	ITPR2,ADCY2
3.868e-02	-3.25	positive regulation of phosphorus metabolic process	biological process	GO:0010562	697	5	18204	49	SLC4A4,ZBTB20,TNIK,NTRK2,TPD52L1
3.868e-02	-3.25	positive regulation of phosphate metabolic process	biological process	GO:0045937	697	5	18204	49	SLC4A4,ZBTB20,NTRK2,TNIK,TPD52L1
3.878e-02	-3.25	actin filament organization	biological process	GO:0007015	278	3	18204	49	FMN2,NEBL,SORBS1
3.878e-02	-3.25	DCC mediated attractive signaling	REACTOME pathways	R-HSA-418885	14	1	10285	29	ABLIM1
3.878e-02	-3.25	SHC1 events in ERBB4 signaling	REACTOME pathways	R-HSA-1250347	14	1	10285	29	NRG3
3.880e-02	-3.25	skin-scalp-carcinoma-squamous_cell_carcinoma	COSMIC cancer mutations	skin-scalp-carcinoma-squamous_cell_carcinoma	1596	9	16828	49	ATP1A2,DST,GPC5,LSAMP,MACF1,SOX5,PTPRZ1,RORA,SLC4A4
3.881e-02	-3.25	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-humerus-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	107	2	16828	49	PARD3B,NEBL
3.900e-02	-3.24	germ_cell_tumour	COSMIC cancer mutations	germ_cell_tumour	867	6	16828	49	PREX2,NTRK2,BMPR1B,TNIK,PRKCA,MACF1
3.908e-02	-3.24	phosphatidylglycerol binding	molecular function	GO:1901611	15	1	18094	48	PITPNC1
3.908e-02	-3.24	filamin binding	molecular function	GO:0031005	15	1	18094	48	NEBL
3.908e-02	-3.24	tropomyosin binding	molecular function	GO:0005523	15	1	18094	48	NEBL
3.914e-02	-3.24	skin-leg-malignant_melanoma-nodular	COSMIC cancer mutations	skin-leg-malignant_melanoma-nodular	258	3	16828	49	SLC4A4,FMN2,PTPRZ1
3.930e-02	-3.24	BRK1 (BRICK1 subunit of SCAR/WAVE actin nucleating complex)	protein interactions	55845	122	2	19454	50	DTNA,NHSL1
3.935e-02	-3.24	perinuclear region of cytoplasm	cellular component	GO:0048471	735	5	19108	49	NTRK2,FMN2,TPD52L1,PRKCA,SLC1A3
3.943e-02	-3.23	human chr10q23.1	chromosome location	human chr10q23.1	21	1	26134	50	NRG3
3.943e-02	-3.23	human chr13q31.3	chromosome location	human chr13q31.3	21	1	26134	50	GPC5
3.947e-02	-3.23	testis-germ_cell_tumour-seminoma	COSMIC cancer mutations	testis-germ_cell_tumour-seminoma	648	5	16828	49	TNIK,PRKCA,BMPR1B,NTRK2,PREX2
3.948e-02	-3.23	glycoprotein biosynthetic process	biological process	GO:0009101	280	3	18204	49	MGAT4C,BMPR1B,CSGALNACT1
3.953e-02	-3.23	chondroitin sulfate biosynthesis	BIOCYC pathways	META_PWY-6569	18	1	902	2	CSGALNACT1
3.964e-02	-3.23	system process	biological process	GO:0003008	2015	10	18204	49	SLC4A4,CTNNA2,DTNA,ABLIM1,SLC1A2,NTRK2,ATP1A2,RYR3,SLC1A3,PTPRZ1
3.964e-02	-3.23	positive regulation of glycogen biosynthetic process	biological process	GO:0045725	15	1	18204	49	SORBS1
3.964e-02	-3.23	synapse maturation	biological process	GO:0060074	15	1	18204	49	NFIA
3.964e-02	-3.23	negative regulation of sodium ion transmembrane transport	biological process	GO:1902306	15	1	18204	49	ATP1A2
3.964e-02	-3.23	response to caffeine	biological process	GO:0031000	15	1	18204	49	RYR3
3.964e-02	-3.23	protein homotrimerization	biological process	GO:0070207	15	1	18204	49	SLC1A2
3.964e-02	-3.23	dorsal/ventral neural tube patterning	biological process	GO:0021904	15	1	18204	49	GLI3
3.964e-02	-3.23	intracellular potassium ion homeostasis	biological process	GO:0030007	15	1	18204	49	ATP1A2
3.964e-02	-3.23	exit from mitosis	biological process	GO:0010458	15	1	18204	49	NFIA
3.964e-02	-3.23	peripheral nervous system neuron development	biological process	GO:0048935	15	1	18204	49	NTRK2
3.964e-02	-3.23	neuroblast division	biological process	GO:0055057	15	1	18204	49	SOX5
3.964e-02	-3.23	cerebellar Purkinje cell layer formation	biological process	GO:0021694	15	1	18204	49	RORA
3.964e-02	-3.23	regulation of neuron projection arborization	biological process	GO:0150011	15	1	18204	49	MACF1
3.964e-02	-3.23	sarcoplasmic reticulum calcium ion transport	biological process	GO:0070296	15	1	18204	49	RYR3
3.964e-02	-3.23	peripheral nervous system neuron differentiation	biological process	GO:0048934	15	1	18204	49	NTRK2
3.975e-02	-3.23	ATPase_P-typ_cation-transptr_C	interpro domains	IPR006068	15	1	18521	50	ATP1A2
3.975e-02	-3.23	FH2_Formin	interpro domains	IPR015425	15	1	18521	50	FMN2
3.975e-02	-3.23	FH2_Formin_sf	interpro domains	IPR042201	15	1	18521	50	FMN2
3.975e-02	-3.23	CNH_dom	interpro domains	IPR001180	15	1	18521	50	TNIK
3.988e-02	-3.22	UBA5 (ubiquitin like modifier activating enzyme 5)	protein interactions	79876	123	2	19454	50	DST,PRKCA
4.008e-02	-3.22	transcription cis-regulatory region binding	molecular function	GO:0000976	1485	8	18094	48	NFIA,RORA,ZBTB20,GLIS3,GLI3,SOX5,RFX4,NPAS3
4.020e-02	-3.21	MAPRE1 (microtubule associated protein RP/EB family member 1)	protein interactions	22919	504	4	19454	50	ABLIM1,PRKCA,MACF1,DST
4.020e-02	-3.21	synapse assembly	biological process	GO:0007416	118	2	18204	49	NRG3,GPM6A
4.023e-02	-3.21	Prot_kinase_dom	interpro domains	IPR000719	480	4	18521	50	TNIK,BMPR1B,PRKCA,NTRK2
4.027e-02	-3.21	postsynaptic density, intracellular component	cellular component	GO:0099092	16	1	19108	49	TNIK
4.035e-02	-3.21	transcription regulatory region nucleic acid binding	molecular function	GO:0001067	1487	8	18094	48	ZBTB20,GLI3,GLIS3,NFIA,RORA,RFX4,NPAS3,SOX5
4.035e-02	-3.21	NRGN (neurogranin)	protein interactions	4900	16	1	19454	50	PRKCA
4.035e-02	-3.21	RHO (rhodopsin)	protein interactions	6010	16	1	19454	50	PRKCA
4.035e-02	-3.21	CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2)	protein interactions	729438	16	1	19454	50	DST
4.035e-02	-3.21	TPD52L3 (TPD52 like 3)	protein interactions	89882	16	1	19454	50	TPD52L1
4.035e-02	-3.21	Sumo3 (small ubiquitin-like modifier 3)	protein interactions	20610	16	1	19454	50	ITPR2
4.035e-02	-3.21	GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13)	protein interactions	114805	16	1	19454	50	TNIK
4.035e-02	-3.21	FNDC8 (fibronectin type III domain containing 8)	protein interactions	54752	16	1	19454	50	SPARCL1
4.035e-02	-3.21	CDH12 (cadherin 12)	protein interactions	1010	16	1	19454	50	CTNNA2
4.035e-02	-3.21	GABRR1 (gamma-aminobutyric acid type A receptor subunit rho1)	protein interactions	2569	16	1	19454	50	PRKCA
4.035e-02	-3.21	SAPCD1 (suppressor APC domain containing 1)	protein interactions	401251	16	1	19454	50	CTNNA2
4.035e-02	-3.21	TWIST2 (twist family bHLH transcription factor 2)	protein interactions	117581	16	1	19454	50	ZBTB20
4.035e-02	-3.21	Prkcz (protein kinase C, zeta)	protein interactions	18762	16	1	19454	50	DST
4.035e-02	-3.21	GABRB3 (gamma-aminobutyric acid type A receptor subunit beta3)	protein interactions	2562	16	1	19454	50	PRKCA
4.035e-02	-3.21	CNTNAP2 (contactin associated protein 2)	protein interactions	26047	16	1	19454	50	MACF1
4.035e-02	-3.21	AMMECR1L (AMMECR1 like)	protein interactions	83607	16	1	19454	50	MACF1
4.035e-02	-3.21	WWC3 (WWC family member 3)	protein interactions	55841	16	1	19454	50	PRKCA
4.035e-02	-3.21	SLC6A9 (solute carrier family 6 member 9)	protein interactions	6536	16	1	19454	50	PRKCA
4.053e-02	-3.21	CNH	pfam domains	PF00780	15	1	17795	49	TNIK
4.053e-02	-3.21	Cation_ATPase_C	pfam domains	PF00689	15	1	17795	49	ATP1A2
4.053e-02	-3.21	FH2	pfam domains	PF02181	15	1	17795	49	FMN2
4.054e-02	-3.21	Wnt signaling pathway	biological process	GO:0016055	283	3	18204	49	MACF1,CTNND2,TNIK
4.092e-02	-3.20	regulation of signaling	biological process	GO:0023051	3534	15	18204	49	SORBS1,PREX2,MACF1,TPD52L1,BMPR1B,NTRK2,ATP1A2,GLI3,PRKCA,CTNND2,GPC5,NRG3,TNIK,RORA,SLC1A3
4.106e-02	-3.19	STXBP1 (syntaxin binding protein 1)	protein interactions	6812	125	2	19454	50	GPM6A,PRKCA
4.106e-02	-3.19	SOCS6 (suppressor of cytokine signaling 6)	protein interactions	9306	125	2	19454	50	BMPR1B,DST
4.112e-02	-3.19	regulation of transmembrane transport	biological process	GO:0034762	485	4	18204	49	ATP1A2,SLC1A2,SORBS1,DPP10
4.117e-02	-3.19	secondary active transmembrane transporter activity	molecular function	GO:0015291	289	3	18094	48	SLC1A3,SLC4A4,SLC1A2
4.118e-02	-3.19	skin-extremity-malignant_melanoma	COSMIC cancer mutations	skin-extremity-malignant_melanoma	1875	10	16828	49	PTPRZ1,RYR3,FMN2,PITPNC1,FBXL7,NTRK2,CDH20,NEBL,PREX2,ADCY2
4.131e-02	-3.19	extremity	COSMIC cancer mutations	extremity	1876	10	16828	49	CDH20,NTRK2,ADCY2,PREX2,NEBL,PTPRZ1,RYR3,PITPNC1,FBXL7,FMN2
4.150e-02	-3.18	Depolymerisation of the Nuclear Lamina	REACTOME pathways	R-HSA-4419969	15	1	10285	29	PRKCA
4.150e-02	-3.18	WNT5A-dependent internalization of FZD4	REACTOME pathways	R-HSA-5099900	15	1	10285	29	PRKCA
4.150e-02	-3.18	Adenylate cyclase inhibitory pathway	REACTOME pathways	R-HSA-170670	15	1	10285	29	ADCY2
4.150e-02	-3.18	ERBB2 Regulates Cell Motility	REACTOME pathways	R-HSA-6785631	15	1	10285	29	NRG3
4.150e-02	-3.18	N-Glycan antennae elongation	REACTOME pathways	R-HSA-975577	15	1	10285	29	MGAT4C
4.150e-02	-3.18	Inhibition of adenylate cyclase pathway	REACTOME pathways	R-HSA-997269	15	1	10285	29	ADCY2
4.156e-02	-3.18	regulation of cell communication	biological process	GO:0010646	3541	15	18204	49	CTNND2,GPC5,SLC1A3,NRG3,TNIK,RORA,BMPR1B,GLI3,PRKCA,NTRK2,ATP1A2,MACF1,TPD52L1,SORBS1,PREX2
4.163e-02	-3.18	adenylate cyclase activity	molecular function	GO:0004016	16	1	18094	48	ADCY2
4.163e-02	-3.18	diacylglycerol-dependent serine/threonine kinase activity	molecular function	GO:0004697	16	1	18094	48	PRKCA
4.163e-02	-3.18	oxysterol binding	molecular function	GO:0008142	16	1	18094	48	RORA
4.166e-02	-3.18	SYP (synaptophysin)	protein interactions	6855	126	2	19454	50	PITPNC1,GPM6A
4.198e-02	-3.17	ossification	biological process	GO:0001503	287	3	18204	49	GLI3,BMPR1B,CSGALNACT1
4.215e-02	-3.17	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	WP3301	12	1	5310	19	RYR3
4.215e-02	-3.17	Bone Morphogenic Protein (BMP) Signalling and Regulation	WikiPathways	WP1425	12	1	5310	19	BMPR1B
4.223e-02	-3.16	spinal cord dorsal/ventral patterning	biological process	GO:0021513	16	1	18204	49	GLI3
4.223e-02	-3.16	nonribosomal peptide biosynthetic process	biological process	GO:0019184	16	1	18204	49	SLC1A2
4.223e-02	-3.16	regulation of amino acid import across plasma membrane	biological process	GO:0010958	16	1	18204	49	ATP1A2
4.223e-02	-3.16	non-proteinogenic amino acid biosynthetic process	biological process	GO:0170043	16	1	18204	49	SLC1A3
4.223e-02	-3.16	locomotory exploration behavior	biological process	GO:0035641	16	1	18204	49	ATP1A2
4.223e-02	-3.16	positive regulation of macrophage differentiation	biological process	GO:0045651	16	1	18204	49	PRKCA
4.223e-02	-3.16	regulation of amino acid transmembrane transport	biological process	GO:1903789	16	1	18204	49	ATP1A2
4.223e-02	-3.16	nose development	biological process	GO:0043584	16	1	18204	49	GLI3
4.223e-02	-3.16	asymmetric cell division	biological process	GO:0008356	16	1	18204	49	SOX5
4.223e-02	-3.16	regulation of respiratory system process	biological process	GO:0044065	16	1	18204	49	ATP1A2
4.240e-02	-3.16	DWA	smart domains	SM00523	12	1	9717	35	NFIA
4.267e-02	-3.15	neuron projection terminus	cellular component	GO:0044306	128	2	19108	49	SLC1A2,NTRK2
4.269e-02	-3.15	Formin, FH2 domain	gene3d domains	1.20.58.2220	15	1	14470	42	FMN2
4.282e-02	-3.15	RASL12 (RAS like family 12)	protein interactions	51285	17	1	19454	50	BMPR1B
4.282e-02	-3.15	Sqstm1 (sequestosome 1)	protein interactions	18412	17	1	19454	50	BMPR1B
4.282e-02	-3.15	CYP3A4 (cytochrome P450 family 3 subfamily A member 4)	protein interactions	1576	17	1	19454	50	PRKCA
4.282e-02	-3.15	LIPT1 (lipoyltransferase 1)	protein interactions	51601	17	1	19454	50	PRKCA
4.282e-02	-3.15	MSANTD2 (Myb/SANT DNA binding domain containing 2)	protein interactions	79684	17	1	19454	50	SOX5
4.282e-02	-3.15	SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)	protein interactions	51091	17	1	19454	50	ABLIM1
4.282e-02	-3.15	PDE7A (phosphodiesterase 7A)	protein interactions	5150	17	1	19454	50	PRKCA
4.282e-02	-3.15	NOTCH4 (notch receptor 4)	protein interactions	4855	17	1	19454	50	MAML2
4.282e-02	-3.15	PAX4 (paired box 4)	protein interactions	5078	17	1	19454	50	NTM
4.282e-02	-3.15	DPP6 (dipeptidyl peptidase like 6)	protein interactions	1804	17	1	19454	50	GPM6A
4.282e-02	-3.15	TAGAP (T cell activation RhoGTPase activating protein)	protein interactions	117289	17	1	19454	50	DTNA
4.282e-02	-3.15	TNNT2 (troponin T2, cardiac type)	protein interactions	7139	17	1	19454	50	PRKCA
4.282e-02	-3.15	Shcbp1 (Shc SH2-domain binding protein 1)	protein interactions	20419	17	1	19454	50	GPC5
4.286e-02	-3.15	ATF7IP (activating transcription factor 7 interacting protein)	protein interactions	55729	128	2	19454	50	MACF1,SOX5
4.286e-02	-3.15	PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta)	protein interactions	5577	128	2	19454	50	GPM6A,PRKCA
4.311e-02	-3.14	human chr5p15.31	chromosome location	human chr5p15.31	23	1	26134	50	ADCY2
4.329e-02	-3.14	ovary-carcinoma-mucinous_carcinoma	COSMIC cancer mutations	ovary-carcinoma-mucinous_carcinoma	456	4	16828	49	BMPR1B,NTRK2,TNIK,PRKCA
4.334e-02	-3.14	ovary-carcinoma-clear_cell_carcinoma	COSMIC cancer mutations	ovary-carcinoma-clear_cell_carcinoma	665	5	16828	49	BMPR1B,NTRK2,PRKCA,TNIK,SPARCL1
4.346e-02	-3.14	CHD7 (chromodomain helicase DNA binding protein 7)	protein interactions	55636	129	2	19454	50	SOX5,ZBTB20
4.350e-02	-3.13	cellular response to growth factor stimulus	biological process	GO:0071363	494	4	18204	49	BMPR1B,NFIA,NTRK2,SOX5
4.350e-02	-3.13	modulation of chemical synaptic transmission	biological process	GO:0050804	494	4	18204	49	SLC1A3,ATP1A2,NTRK2,NRG3
4.362e-02	-3.13	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	COSMIC cancer mutations	bone-extraskeletal-Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	891	6	16828	49	SPARCL1,ATP1A2,PTPRZ1,ABLIM1,ITPR2,NPAS3
4.366e-02	-3.13	channel activity	molecular function	GO:0015267	502	4	18094	48	RYR3,TRPM3,ITPR2,GPM6A
4.377e-02	-3.13	regulation of trans-synaptic signaling	biological process	GO:0099177	495	4	18204	49	SLC1A3,NRG3,ATP1A2,NTRK2
4.381e-02	-3.13	response to hypoxia	biological process	GO:0001666	292	3	18204	49	FMN2,ITPR2,RORA
4.388e-02	-3.13	mucinous_carcinoma	COSMIC cancer mutations	mucinous_carcinoma	458	4	16828	49	NTRK2,BMPR1B,PRKCA,TNIK
4.392e-02	-3.13	passive transmembrane transporter activity	molecular function	GO:0022803	503	4	18094	48	GPM6A,ITPR2,TRPM3,RYR3
4.397e-02	-3.12	positive regulation of lipid metabolic process	biological process	GO:0045834	124	2	18204	49	ZBTB20,SORBS1
4.397e-02	-3.12	action potential	biological process	GO:0001508	124	2	18204	49	ATP1A2,NTRK2
4.400e-02	-3.12	basal part of cell	cellular component	GO:0045178	307	3	19108	49	DST,SLC4A4,SLC1A3
4.417e-02	-3.12	transmembrane receptor protein phosphatase activity	molecular function	GO:0019198	17	1	18094	48	PTPRZ1
4.417e-02	-3.12	transmembrane receptor protein tyrosine phosphatase activity	molecular function	GO:0005001	17	1	18094	48	PTPRZ1
4.420e-02	-3.12	PI3K events in ERBB2 signaling	REACTOME pathways	R-HSA-1963642	16	1	10285	29	NRG3
4.420e-02	-3.12	Regulation of KIT signaling	REACTOME pathways	R-HSA-1433559	16	1	10285	29	PRKCA
4.420e-02	-3.12	PKA activation	REACTOME pathways	R-HSA-163615	16	1	10285	29	ADCY2
4.420e-02	-3.12	GRB2 events in ERBB2 signaling	REACTOME pathways	R-HSA-1963640	16	1	10285	29	NRG3
4.428e-02	-3.12	clear_cell_carcinoma	COSMIC cancer mutations	clear_cell_carcinoma	669	5	16828	49	SPARCL1,BMPR1B,NTRK2,TNIK,PRKCA
4.446e-02	-3.11	G Protein Signaling Pathways	WikiPathways	WP35	95	2	5310	19	ADCY2,PRKCA
4.448e-02	-3.11	PDZ	pfam domains	PF00595	122	2	17795	49	PREX2,PARD3B
4.461e-02	-3.11	actomyosin structure organization	biological process	GO:0031032	125	2	18204	49	SORBS1,NEBL
4.461e-02	-3.11	mammary gland development	biological process	GO:0030879	125	2	18204	49	NRG3,GLI3
4.461e-02	-3.11	cerebral cortex development	biological process	GO:0021987	125	2	18204	49	NTRK2,GLI3
4.467e-02	-3.11	regulation of cellular process	biological process	GO:0050794	11468	37	18204	49	GPM6A,PTPRZ1,TPD52L1,GLIS3,MSI2,SORBS1,ADCY2,GPC5,CTNND2,TNIK,DPP10,DTNA,CTNNA2,ZBTB20,BMPR1B,SOX5,PRKCA,FMN2,NTRK2,MACF1,RFX4,NPAS3,NFIA,SPARCL1,PREX2,SLC1A2,DST,PITPNC1,RYR3,SLC1A3,NRG3,RORA,SLC4A4,GLI3,ITPR2,ATP1A2,MAML2
4.468e-02	-3.11	TRPS1 (transcriptional repressor GATA binding 1)	protein interactions	7227	131	2	19454	50	NFIA,SOX5
4.468e-02	-3.11	ZNF609 (zinc finger protein 609)	protein interactions	23060	131	2	19454	50	SOX5,NFIA
4.468e-02	-3.11	NCOA2 (nuclear receptor coactivator 2)	protein interactions	10499	131	2	19454	50	RORA,NFIA
4.481e-02	-3.11	cGMP metabolic process	biological process	GO:0046068	17	1	18204	49	RORA
4.481e-02	-3.11	protein trimerization	biological process	GO:0070206	17	1	18204	49	SLC1A2
4.481e-02	-3.11	specification of animal organ identity	biological process	GO:0010092	17	1	18204	49	GLI3
4.481e-02	-3.11	retinal rod cell differentiation	biological process	GO:0060221	17	1	18204	49	NTRK2
4.481e-02	-3.11	T-helper 17 type immune response	biological process	GO:0072538	17	1	18204	49	RORA
4.481e-02	-3.11	microvillus assembly	biological process	GO:0030033	17	1	18204	49	TNIK
4.481e-02	-3.11	cellular response to ATP	biological process	GO:0071318	17	1	18204	49	RYR3
4.481e-02	-3.11	membrane depolarization during cardiac muscle cell action potential	biological process	GO:0086012	17	1	18204	49	ATP1A2
4.481e-02	-3.11	cell migration in hindbrain	biological process	GO:0021535	17	1	18204	49	CTNNA2
4.481e-02	-3.11	heparin metabolic process	biological process	GO:0030202	17	1	18204	49	CSGALNACT1
4.481e-02	-3.11	embryonic digestive tract morphogenesis	biological process	GO:0048557	17	1	18204	49	GLI3
4.481e-02	-3.11	cell communication by electrical coupling involved in cardiac conduction	biological process	GO:0086064	17	1	18204	49	ATP1A2
4.481e-02	-3.11	positive regulation of glycogen metabolic process	biological process	GO:0070875	17	1	18204	49	SORBS1
4.481e-02	-3.11	viral genome replication	biological process	GO:0019079	17	1	18204	49	NFIA
4.481e-02	-3.11	ureter development	biological process	GO:0072189	17	1	18204	49	NFIA
4.493e-02	-3.10	A/G_cyclase_CS	interpro domains	IPR018297	17	1	18521	50	ADCY2
4.493e-02	-3.10	CA_dom	interpro domains	IPR001148	17	1	18521	50	PTPRZ1
4.493e-02	-3.10	CA_dom_sf	interpro domains	IPR036398	17	1	18521	50	PTPRZ1
4.507e-02	-3.10	ductal_carcinoma	COSMIC cancer mutations	ductal_carcinoma	15798	49	16828	49	GPM6A,PREX2,NTM,NPAS3,TRPM3,MGAT4C,FBXL7,SLC1A2,NKAIN3,PTPRZ1,LSAMP,ADCY2,CDH20,NTRK2,DST,PITPNC1,NHSL1,SPARCL1,TNIK,SOX5,SLC1A3,NEBL,MACF1,CSGALNACT1,BMPR1B,NFIA,MAML2,PRKCA,ATP1A2,ITPR2,SORBS1,DTNA,RYR3,PAMR1,GPC5,MSI2,PARD3B,ABLIM1,TPD52L1,NRG3,ZBTB20,RFX4,GLIS3,SLC4A4,FMN2,CTNND2,DPP10,RORA,GLI3
4.525e-02	-3.10	limbic system development	biological process	GO:0021761	126	2	18204	49	ATP1A2,GLI3
4.529e-02	-3.09	TTC29 (tetratricopeptide repeat domain 29)	protein interactions	83894	18	1	19454	50	MACF1
4.529e-02	-3.09	NKIRAS1 (NFKB inhibitor interacting Ras like 1)	protein interactions	28512	18	1	19454	50	BMPR1B
4.529e-02	-3.09	SELL (selectin L)	protein interactions	6402	18	1	19454	50	PRKCA
4.529e-02	-3.09	KLHL1 (kelch like family member 1)	protein interactions	57626	18	1	19454	50	BMPR1B
4.529e-02	-3.09	OPCML (opioid binding protein/cell adhesion molecule like)	protein interactions	4978	18	1	19454	50	NTM
4.529e-02	-3.09	Cnot2 (CCR4-NOT transcription complex, subunit 2)	protein interactions	72068	18	1	19454	50	MACF1
4.529e-02	-3.09	Tgfbr1 (transforming growth factor, beta receptor I)	protein interactions	21812	18	1	19454	50	BMPR1B
4.529e-02	-3.09	ACAP1 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 1)	protein interactions	9744	18	1	19454	50	NEBL
4.558e-02	-3.09	Cell-type Dependent Selectivity of CCK2R Signaling	WikiPathways	WP3679	13	1	5310	19	RYR3
4.565e-02	-3.09	ovary-carcinoma-endometrioid_carcinoma	COSMIC cancer mutations	ovary-carcinoma-endometrioid_carcinoma	464	4	16828	49	TNIK,PRKCA,NTRK2,BMPR1B
4.569e-02	-3.09	carboxylic acid transport	biological process	GO:0046942	297	3	18204	49	SLC1A3,NTRK2,SLC1A2
4.569e-02	-3.09	muscle system process	biological process	GO:0003012	297	3	18204	49	DTNA,RYR3,ATP1A2
4.569e-02	-3.09	Serotonergic synapse	KEGG pathways	hsa04726	112	2	7161	22	PRKCA,ITPR2
4.573e-02	-3.08	carbohydrate derivative metabolic process	biological process	GO:1901135	975	6	18204	49	ATP1A2,RORA,MGAT4C,CSGALNACT1,BMPR1B,ADCY2
4.581e-02	-3.08	Carb_anhydrase	pfam domains	PF00194	17	1	17795	49	PTPRZ1
4.581e-02	-3.08	ZZ	pfam domains	PF00569	17	1	17795	49	DTNA
4.590e-02	-3.08	response to amino acid	biological process	GO:0043200	127	2	18204	49	NTRK2,SLC1A2
4.590e-02	-3.08	cell-cell junction assembly	biological process	GO:0007043	127	2	18204	49	CDH20,PRKCA
4.597e-02	-3.08	protein phosphorylation	biological process	GO:0006468	503	4	18204	49	PRKCA,NTRK2,TNIK,BMPR1B
4.604e-02	-3.08	SLC-mediated transmembrane transport	REACTOME pathways	R-HSA-425407	287	3	10285	29	SLC4A4,SLC1A2,SLC1A3
4.606e-02	-3.08	extraskeletal	COSMIC cancer mutations	extraskeletal	903	6	16828	49	NPAS3,ITPR2,ABLIM1,PTPRZ1,ATP1A2,SPARCL1
4.607e-02	-3.08	organic acid transport	biological process	GO:0015849	298	3	18204	49	NTRK2,SLC1A2,SLC1A3
4.641e-02	-3.07	positive regulation of transcription by RNA polymerase II	biological process	GO:0045944	1237	7	18204	49	GLI3,MAML2,NFIA,BMPR1B,RORA,GLIS3,RFX4
4.652e-02	-3.07	monoatomic cation homeostasis	biological process	GO:0055080	505	4	18204	49	SLC4A4,RYR3,SLC1A3,ATP1A2
4.653e-02	-3.07	NUFIP1 (nuclear FMR1 interacting protein 1)	protein interactions	26747	134	2	19454	50	GPM6A,NTM
4.671e-02	-3.06	transmembrane receptor protein tyrosine kinase activator activity	molecular function	GO:0030297	18	1	18094	48	NRG3
4.671e-02	-3.06	phosphatidylcholine transporter activity	molecular function	GO:0008525	18	1	18094	48	PITPNC1
4.690e-02	-3.06	PKA-mediated phosphorylation of CREB	REACTOME pathways	R-HSA-111931	17	1	10285	29	ADCY2
4.690e-02	-3.06	Trafficking of GluR2-containing AMPA receptors	REACTOME pathways	R-HSA-416993	17	1	10285	29	PRKCA
4.690e-02	-3.06	PKA activation in glucagon signalling	REACTOME pathways	R-HSA-164378	17	1	10285	29	ADCY2
4.690e-02	-3.06	Elevation of cytosolic Ca2+ levels	REACTOME pathways	R-HSA-139853	17	1	10285	29	ITPR2
4.716e-02	-3.05	FOXP1 (forkhead box P1)	protein interactions	27086	135	2	19454	50	SOX5,NFIA
4.716e-02	-3.05	MTNR1B (melatonin receptor 1B)	protein interactions	4544	135	2	19454	50	DST,MACF1
4.718e-02	-3.05	Leukocyte transendothelial migration	KEGG pathways	hsa04670	114	2	7161	22	CTNNA2,PRKCA
4.718e-02	-3.05	Leukocyte transendothelial migration	KEGG pathways	ko04670	114	2	7161	22	CTNNA2,PRKCA
4.720e-02	-3.05	response to organophosphorus	biological process	GO:0046683	129	2	18204	49	ITPR2,RYR3
4.722e-02	-3.05	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	COSMIC cancer mutations	central_nervous_system-brain-glioma-astrocytoma_Grade_IV	15813	49	16828	49	MAML2,NFIA,PRKCA,ATP1A2,ITPR2,NEBL,BMPR1B,MACF1,CSGALNACT1,ADCY2,NTRK2,CDH20,NHSL1,SPARCL1,DST,PITPNC1,SLC1A3,TNIK,SOX5,PREX2,GPM6A,NTM,MGAT4C,NPAS3,TRPM3,NKAIN3,FBXL7,SLC1A2,LSAMP,PTPRZ1,RORA,GLI3,SLC4A4,TPD52L1,NRG3,GLIS3,RFX4,ZBTB20,FMN2,DPP10,CTNND2,MSI2,PARD3B,ABLIM1,SORBS1,DTNA,GPC5,RYR3,PAMR1
4.737e-02	-3.05	circulatory system process	biological process	GO:0003013	508	4	18204	49	ATP1A2,SLC1A2,SLC1A3,SLC4A4
4.737e-02	-3.05	Glycosaminoglycan metabolism	REACTOME pathways	R-HSA-1630316	124	2	10285	29	GPC5,CSGALNACT1
4.738e-02	-3.05	cardiac myofibril assembly	biological process	GO:0055003	18	1	18204	49	NEBL
4.738e-02	-3.05	negative regulation of anoikis	biological process	GO:2000811	18	1	18204	49	NTRK2
4.738e-02	-3.05	maintenance of cell polarity	biological process	GO:0030011	18	1	18204	49	DST
4.738e-02	-3.05	spinal cord patterning	biological process	GO:0021511	18	1	18204	49	GLI3
4.738e-02	-3.05	dendritic spine morphogenesis	biological process	GO:0060997	18	1	18204	49	CTNND2
4.738e-02	-3.05	positive regulation of circadian rhythm	biological process	GO:0042753	18	1	18204	49	RORA
4.738e-02	-3.05	negative regulation of sodium ion transport	biological process	GO:0010766	18	1	18204	49	ATP1A2
4.749e-02	-3.05	positive regulation of cell communication	biological process	GO:0010647	1792	9	18204	49	SLC1A3,TPD52L1,TNIK,GPC5,MACF1,PRKCA,NTRK2,SORBS1,BMPR1B
4.752e-02	-3.05	Leu-rich_rpt_Cys-con_subtyp	interpro domains	IPR006553	18	1	18521	50	FBXL7
4.752e-02	-3.05	ATPase_P-typ_cation-transptr_N	interpro domains	IPR004014	18	1	18521	50	ATP1A2
4.752e-02	-3.05	Nucleotide_cyclase	interpro domains	IPR029787	18	1	18521	50	ADCY2
4.752e-02	-3.05	A/G_cyclase	interpro domains	IPR001054	18	1	18521	50	ADCY2
4.761e-02	-3.04	postsynaptic density	cellular component	GO:0014069	317	3	19108	49	TNIK,NTRK2,CTNND2
4.764e-02	-3.04	astrocyte projection	cellular component	GO:0097449	19	1	19108	49	SLC1A2
4.764e-02	-3.04	postsynaptic specialization, intracellular component	cellular component	GO:0099091	19	1	19108	49	TNIK
4.764e-02	-3.04	cation-transporting ATPase complex	cellular component	GO:0090533	19	1	19108	49	ATP1A2
4.764e-02	-3.04	parallel fiber to Purkinje cell synapse	cellular component	GO:0098688	19	1	19108	49	GPM6A
4.768e-02	-3.04	primary_central_nervous_system_lymphoma	COSMIC cancer mutations	primary_central_nervous_system_lymphoma	683	5	16828	49	MACF1,PARD3B,NRG3,DST,ZBTB20
4.768e-02	-3.04	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	COSMIC cancer mutations	haematopoietic_and_lymphoid_tissue-central_nervous_system-lymphoid_neoplasm-primary_central_nervous_system_lymphoma	683	5	16828	49	MACF1,PARD3B,NRG3,DST,ZBTB20
4.769e-02	-3.04	SMURF1 (SMAD specific E3 ubiquitin protein ligase 1)	protein interactions	57154	533	4	19454	50	FMN2,TNIK,BMPR1B,PRKCA
4.774e-02	-3.04	GCHFR (GTP cyclohydrolase I feedback regulator)	protein interactions	2644	19	1	19454	50	NEBL
4.774e-02	-3.04	OSM (oncostatin M)	protein interactions	5008	19	1	19454	50	TRPM3
4.774e-02	-3.04	SPZ1 (spermatogenic leucine zipper 1)	protein interactions	84654	19	1	19454	50	DTNA
4.774e-02	-3.04	C3orf62 (chromosome 3 open reading frame 62)	protein interactions	375341	19	1	19454	50	ATP1A2
4.774e-02	-3.04	TNR (tenascin R)	protein interactions	7143	19	1	19454	50	PTPRZ1
4.774e-02	-3.04	RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)	protein interactions	6236	19	1	19454	50	PRKCA
4.774e-02	-3.04	RIT2 (Ras like without CAAX 2)	protein interactions	6014	19	1	19454	50	DTNA
4.774e-02	-3.04	INKA1 (inka box actin regulator 1)	protein interactions	389119	19	1	19454	50	ZBTB20
4.774e-02	-3.04	PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)	protein interactions	84457	19	1	19454	50	GPM6A
4.774e-02	-3.04	TRPV6 (transient receptor potential cation channel subfamily V member 6)	protein interactions	55503	19	1	19454	50	PRKCA
4.774e-02	-3.04	JSRP1 (junctional sarcoplasmic reticulum protein 1)	protein interactions	126306	19	1	19454	50	PRKCA
4.774e-02	-3.04	CNTNAP4 (contactin associated protein family member 4)	protein interactions	85445	19	1	19454	50	MACF1
4.777e-02	-3.04	positive regulation of signaling	biological process	GO:0023056	1794	9	18204	49	BMPR1B,SORBS1,NTRK2,PRKCA,GPC5,MACF1,TNIK,TPD52L1,SLC1A3
4.793e-02	-3.04	skin-back-malignant_melanoma	COSMIC cancer mutations	skin-back-malignant_melanoma	280	3	16828	49	ATP1A2,PREX2,TNIK
4.809e-02	-3.03	N-glycan biosynthesis, complex type	KEGG pathways	M00075	16	1	7161	22	MGAT4C
4.809e-02	-3.03	cAMP signaling	KEGG pathways	hsa_M00695	16	1	7161	22	ADCY2
4.809e-02	-3.03	cAMP signaling	KEGG pathways	M00695	16	1	7161	22	ADCY2
4.809e-02	-3.03	N-glycan biosynthesis, complex type	KEGG pathways	hsa_M00075	16	1	7161	22	MGAT4C
4.815e-02	-3.03	FH2	prosite domains	PS51444	15	1	12186	40	FMN2
4.815e-02	-3.03	CNH	prosite domains	PS50219	15	1	12186	40	TNIK
4.822e-02	-3.03	mitotic cell cycle process	biological process	GO:1903047	511	4	18204	49	NFIA,FBXL7,PRKCA,TPD52L1
4.824e-02	-3.03	Alpha carbonic anhydrase	gene3d domains	3.10.200.10	17	1	14470	42	PTPRZ1
4.842e-02	-3.03	TBL1X (transducin beta like 1 X-linked)	protein interactions	6907	137	2	19454	50	SOX5,NFIA
4.843e-02	-3.03	Ras signaling in the CD4+ TCR pathway	Pathway Interaction DB	tcrraspathway	11	1	2226	10	PRKCA
4.843e-02	-3.03	oligoastrocytoma_Grade_II	COSMIC cancer mutations	oligoastrocytoma_Grade_II	121	2	16828	49	CDH20,DTNA
4.844e-02	-3.03	Cation_ATPase_N	pfam domains	PF00690	18	1	17795	49	ATP1A2
4.844e-02	-3.03	Guanylate_cyc	pfam domains	PF00211	18	1	17795	49	ADCY2
4.852e-02	-3.03	carboxylic acid transmembrane transport	biological process	GO:1905039	131	2	18204	49	SLC1A3,SLC1A2
4.859e-02	-3.02	human chr18q12.1	chromosome location	human chr18q12.1	26	1	26134	50	DTNA
4.867e-02	-3.02	Thyroid hormone signaling pathway	KEGG pathways	hsa04919	116	2	7161	22	ATP1A2,PRKCA
4.900e-02	-3.02	ERK Pathway in Huntington's Disease	WikiPathways	WP3853	14	1	5310	19	NTRK2
4.905e-02	-3.01	EXOC1 (exocyst complex component 1)	protein interactions	55763	138	2	19454	50	MACF1,DST
4.905e-02	-3.01	NFIB (nuclear factor I B)	protein interactions	4781	138	2	19454	50	SOX5,NFIA
4.911e-02	-3.01	sequence-specific double-stranded DNA binding	molecular function	GO:1990837	1547	8	18094	48	SOX5,NPAS3,RFX4,NFIA,RORA,ZBTB20,GLI3,GLIS3
4.916e-02	-3.01	response to decreased oxygen levels	biological process	GO:0036293	306	3	18204	49	FMN2,ITPR2,RORA
4.924e-02	-3.01	alkali metal ion binding	molecular function	GO:0031420	19	1	18094	48	ATP1A2
4.924e-02	-3.01	transmembrane receptor protein serine/threonine kinase activity	molecular function	GO:0004675	19	1	18094	48	BMPR1B
4.930e-02	-3.01	CNH	smart domains	SM00036	14	1	9717	35	TNIK
4.937e-02	-3.01	monoatomic ion homeostasis	biological process	GO:0050801	515	4	18204	49	RYR3,SLC4A4,ATP1A2,SLC1A3
4.966e-02	-3.00	cell division	biological process	GO:0051301	516	4	18204	49	PARD3B,FMN2,SOX5,FBXL7
4.968e-02	-3.00	SPCS2 (signal peptidase complex subunit 2)	protein interactions	9789	139	2	19454	50	MGAT4C,GPC5
4.983e-02	-3.00	PK_Tyr_Ser-Thr	pfam domains	PF07714	130	2	17795	49	NTRK2,BMPR1B
4.987e-02	-3.00	ligand-gated monoatomic cation channel activity	molecular function	GO:0099094	135	2	18094	48	RYR3,ITPR2
4.995e-02	-3.00	microvillus organization	biological process	GO:0032528	19	1	18204	49	TNIK
4.995e-02	-3.00	positive regulation of bone resorption	biological process	GO:0045780	19	1	18204	49	PRKCA
4.995e-02	-3.00	vocalization behavior	biological process	GO:0071625	19	1	18204	49	GLI3
4.995e-02	-3.00	craniofacial suture morphogenesis	biological process	GO:0097094	19	1	18204	49	GLI3
4.995e-02	-3.00	chondroitin sulfate biosynthetic process	biological process	GO:0030206	19	1	18204	49	CSGALNACT1
4.995e-02	-3.00	response to potassium ion	biological process	GO:0035864	19	1	18204	49	ATP1A2
4.995e-02	-3.00	cerebellar Purkinje cell layer morphogenesis	biological process	GO:0021692	19	1	18204	49	RORA
4.995e-02	-3.00	regulation of neurotransmitter uptake	biological process	GO:0051580	19	1	18204	49	ATP1A2