TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
R-HSA-72766	Translation	8.35188865605755e-17	-37.0214588812581	162	102	0.0315887271601115	3229	10285	55176,10952,6143,51121,26986,8891,6747,8664,6160,6136,28972,51504,8669,6203,58477,6205,6187,6204,51065,9349,6209,6208,6746,6130,27335,6152,1915,1975,6734,6122,2197,6161,9669,1974,3921,6157,7458,23471,6729,6175,6191,6218,8892,1937,6231,6132,6181,1977,11224,6134,6139,6188,8666,8894,6146,3646,6133,6141,8893,6129,7311,6168,6228,6206,6155,6124,6170,6727,1933,6201,6154,6159,4736,6745,6147,9789,6158,6731,6165,1938,6229,29927,6217,60559,6224,6128,327,6233,6207,140801,23521,6235,1965,23478,6176,1964,6234,6138,23480,6193,6184,2107	SEC61A2,SEC61B,RPL19,RPL26L1,PABPC1,EIF2B3,SSR3,EIF3D,RPL31,RPL12,SPCS1,TRMT112,EIF3J,RPS9,SRPRB,RPS11,RPS2,RPS10,RPS27L,RPL23,RPS15,RPS14,SSR2,RPL7A,EIF3K,RPL24,EEF1A1,EIF4B,SRPRA,RPL3,FAU,RPL32,EIF5B,EIF4A2,RPSA,RPL27A,EIF4H,TRAM1,SRP54,RPLP0,RPS4X,RPS17,EIF2B2,EEF1G,RPS26,RPL8,RPLP2,EIF4E,RPL35,RPL10,RPL17,RPS3,EIF3G,EIF2S2,RPL22,EIF3E,RPL9,RPL18,EIF2B5,RPL7,UBA52,RPL37A,RPS23,RPS12,RPL27,RPL4,RPL39,SRP14,EEF1B2,RPS7,RPL26,RPL29,RPL10A,SSR1,RPL23A,SPCS2,RPL28,SRP72,RPL35A,EEF2,RPS24,SEC61A1,RPS16,SPCS3,RPS20,RPL6,APEH,RPS27A,RPS13,RPL10L,RPL13A,RPS29,EIF2S1,SEC11A,RPLP1,EIF1AX,RPS28,RPL15,SEC61G,RPS5,RPN1,ETF1
R-HSA-5663205	Infectious disease	2.04232703163896e-16	-36.1272716283707	388	198	0.06131929389904	3229	10285	6749,6843,6217,2071,6882,1938,6128,6224,5687,2968,27183,6165,51534,22916,7979,5692,6207,140801,6233,6235,5702,6141,6133,6804,6616,375,5691,919,11224,160,902,5686,6139,6873,5478,6714,3836,6159,4736,7311,6155,6206,2958,5436,6124,6827,6879,6881,6228,3838,6161,2197,920,57122,1173,5438,6208,127833,6152,1175,25978,6231,6218,2960,9861,6181,1839,6132,5721,27243,129401,6175,5693,5684,1500,60489,5709,5611,5695,10898,940,6143,5705,5699,567,8815,2957,5713,51065,6204,6500,9349,8907,867,2966,6921,6229,5700,2959,1234,5608,5045,1025,6147,6844,6158,3320,11097,5690,5707,5432,7251,3159,9899,9525,6138,23636,6234,5062,6193,5710,404672,928,6880,5682,6176,8905,23521,1499,9636,3326,51510,6134,6146,7296,4233,291,6188,5431,6154,6201,4331,6170,5716,6917,6168,6129,5604,2963,5718,6122,811,292,7520,3921,5610,51160,5901,79023,2926,7514,6130,2962,2237,9146,92421,6829,5698,9972,6157,6191,6160,5704,7852,5689,10762,6136,51121,5683,5694,122706,5685,5606,79872,9844,6209,1022,5720,2961,7314,5902,5433,5441,6203,6187,6205,10213,5435	SSRP1,VAMP1,RPS16,ERCC3,TAF11,EEF2,RPL6,RPS20,PSMA6,GTF2H4,VPS4A,RPL35A,VTA1,NCBP2,SEM1,PSMB4,RPS13,RPL10L,RPS27A,RPS29,PSMC3,RPL18,RPL9,STX1A,SNAP25,ARF1,PSMB3,CD247,RPL35,AP2A1,CCNH,PSMA5,RPL17,TAF2,PPIA,SRC,KPNA1,RPL29,RPL10A,UBA52,RPL27,RPS12,GTF2A2,POLR2G,RPL4,SUPT4H1,TAF7,TAF10,RPS23,KPNA2,RPL32,FAU,CD4,NUP107,AP2M1,POLR2I,RPS14,SYT2,RPL24,AP2S1,CHMP2B,RPS26,RPS17,GTF2E1,PSMD6,RPLP2,HBEGF,RPL8,PSME2,CHMP2A,NUP35,RPLP0,PSMB5,PSMA3,CTNND1,APOBEC3G,PSMD3,DNAJC3,PSMB7,CPSF4,CD28,RPL19,PSMC5,PSMB10,B2M,BANF1,GTF2A1,PSMD7,RPS27L,RPS10,SKP1,RPL23,AP1M1,CBL,GTF2H2,ELOC,RPS24,PSMC1,GTF2B,CCR5,MAP2K6,FURIN,CDK9,RPL23A,VAMP2,RPL28,HSP90AA1,NUP42,PSMB2,PSMD1,POLR2C,TSG101,HMGA1,SV2B,VPS4B,RPL15,NUP62,RPS28,PAK2,RPS5,PSMD4,GTF2H5,CD9,TAF9,PSMA1,RPLP1,AP1S2,RPL13A,CTNNB1,ISG15,HSP90AB1,CHMP5,RPL10,RPL22,TXNRD1,MET,SLC25A4,RPS3,POLR2B,RPL26,RPS7,MNAT1,RPL39,PSMD10,TCEA1,RPL37A,RPL7,MAP2K1,GTF2F2,PSMD12,RPL3,CALR,SLC25A5,XRCC5,RPSA,EIF2AK2,VPS28,RAN,NUP37,GRSF1,XPO1,RPL7A,GTF2F1,FEN1,HGS,CHMP4C,SUPT5H,PSMB9,NUP153,RPL27A,RPS4X,RPL31,PSMC4,CXCR4,PSMB1,NUP50,RPL12,RPL26L1,PSMA2,PSMB6,PSMB11,PSMA4,MAP2K3,CBLL1,ELMO1,RPS15,CDK7,PSME1,GTF2E2,UBB,RANBP1,POLR2D,POLR2L,RPS9,RPS2,RPS11,PSMD14,POLR2F
R-HSA-392499	Metabolism of proteins	2.73551594443237e-16	-35.8350414246914	1619	650	0.201300712294828	3229	10285	6811,2109,5265,5373,6015,56160,6478,6048,5873,10213,10905,8934,7320,6711,1215,26503,26986,10477,5694,498,5683,6747,51299,29925,25950,5685,5704,6613,55014,6347,991,5689,196483,51504,8669,29844,5862,254013,8345,8818,29954,6191,8331,9146,10342,51142,54959,115827,9972,51272,329,284098,55741,2395,27335,80070,10694,390243,7494,7416,7349,118,3014,10600,6122,811,1678,8607,10440,503542,2784,2793,1725,10106,51255,3190,79023,57506,1803,55907,4000,205564,6129,9656,11316,149371,2158,56254,5126,5204,283899,3416,57393,6201,10175,257194,2677,8604,8342,92815,6134,5865,8894,6146,7328,9868,6468,291,6188,2787,2688,5279,2530,8073,4189,9037,617,122553,7991,116442,23478,51287,5682,23521,79090,80273,10383,9554,7353,9570,10113,406974,6612,6844,6158,5707,5872,79594,966,1537,9230,6484,60559,5082,1509,1780,4089,5045,55738,84749,653509,8915,7903,643847,58477,3312,5201,10282,8703,51009,7264,7319,7095,51065,23627,6204,256435,3952,81794,8693,9527,3486,1075,6143,567,100313843,8891,8774,7709,3329,54927,8348,89978,11014,7703,5972,51602,8350,11236,86,90268,28972,51715,10418,11031,7458,5887,11282,255626,43,54543,9804,7070,11320,1937,285381,7184,79589,91833,4801,10671,5721,57122,51651,4311,4086,5878,6152,116150,1915,9314,9628,4738,1974,10026,94115,4609,2197,6161,10474,5476,56648,5876,55763,79644,27338,6396,4088,30001,6155,6881,1069,4792,6727,10376,6159,6441,26224,4736,51164,5691,23256,1977,2790,2762,51128,11021,5686,11231,9097,131474,8666,22845,506,6804,221613,2890,11070,51560,6207,9363,3309,327,632,6233,81847,100272147,5080,7323,3703,8334,7157,5868,6235,9960,51762,2683,7329,23586,1964,151194,672,467,8078,2028,2590,5870,114548,10452,338328,1471,10574,25813,3093,6901,2773,51209,8702,2155,8678,2775,64924,100137049,11047,8329,29927,7334,2159,6217,7846,29086,6128,79139,474382,2781,516,6224,7155,150274,7314,10130,9367,3479,6203,79695,6187,2788,51693,7332,7327,6205,84628,85236,11336,55135,55970,6209,23770,5720,131118,4800,9101,7417,8970,1603,51121,22944,10952,122706,1605,4062,1048,11258,6480,4245,6160,79672,8775,8314,5861,154,81876,10762,100188893,6136,1460,54512,26519,80267,51738,85365,6157,1457,8655,2931,6729,55294,5698,140838,11041,26984,7189,9695,90639,79577,6746,6130,10670,26286,26521,80349,6734,1975,5617,51226,54732,5718,1080,7128,9099,8790,27314,3921,220441,58485,6168,23193,51014,5885,51552,2147,253827,5371,6154,10651,6170,9486,1933,8869,4253,5716,51764,6709,372,5728,23621,6477,11340,123228,10640,30827,60,10454,332,5627,3183,5710,10981,9215,4597,6176,8733,1965,1499,8335,10559,6138,10945,8841,23636,10678,6234,83452,6440,29926,4069,100287932,6464,23480,6184,6193,6147,7341,5690,11097,2350,440138,2791,2348,6229,5700,8724,83475,3576,9382,84447,51399,2589,9331,55777,6482,51013,23423,5713,10159,54331,10897,8766,10652,64135,9349,1363,249,9958,8658,55176,7295,5705,148867,51734,29090,5699,5423,50,4087,55284,8664,407043,5684,5693,7276,10956,5709,6675,5695,5611,55033,23471,4758,890,129401,56993,407012,59345,22948,1043,5111,6175,6231,80351,51010,468,6218,9526,8892,1798,3487,6950,9861,2673,326624,6181,6132,7321,4286,125476,2785,6208,354,7844,5867,1649,167227,5277,9545,5202,2771,3015,9669,9929,3013,6905,9117,7048,7311,80740,2782,401409,6206,79609,6124,55770,6228,2033,23203,56957,3623,8554,10471,5203,9245,11224,26517,10576,3646,6139,27430,7347,6133,1781,10617,6141,4193,5340,8893,120526,134266,5864,27095,9986,9810,375,140801,367,7186,57403,29071,3998,5702,22931,9510,7979,7150,2107,5692,10484,3972,6483,9789,5687,6745,7109,29906,64841,6165,29880,6731,55343,64409,57559,2923,1911,378,1938,79091,6818,51611,8975,9445,10063	STX5,ETFB,SERPINA1,PMM2,RING1,NSMCE3,SIAH2,RNF5,RAB27A,PSMD14,MAN1A2,RAB29,UBE2B,SPTBN1,CMA1,SLC17A5,PABPC1,UBE2E3,PSMB6,ATP5F1A,PSMA2,SSR3,NRN1,GMPPB,RWDD3,PSMA4,PSMC4,SUMO2,STX17,CCL2,CDC20,PSMB1,EEF2KMT,TRMT112,EIF3J,TFPT,RAB2A,ETFBKMT,H2BC9,DPM2,POMT2,RPS4X,H2AC14,HGS,TFG,CHCHD2,ODAM,RAB3C,NUP153,BET1L,BIRC2,PIGW,EDEM2,FXN,EIF3K,ADAMTS20,CCT8,IZUMO1R,XBP1,VDAC1,UCN,ADD1,H2AX,USP16,RPL3,CALR,TIMM8A,RUVBL1,TIMM17A,SPRN,GNB3,GNGT2,DHPS,CTDSP2,RNF181,HNRNPK,NUP37,MAVS,DPP4,CMAS,LMNA,SENP5,RPL7,MDC1,COPE,EXOC8,F9,RNF20,PCSK2,PFDN5,INO80E,IDE,CLTRN,RPS7,CNIH1,NEGR1,GGCX,SLC25A12,H2BC14,H2AC25,RPL10,RAB3B,EIF2S2,RPL22,UBE2H,TOMM70,FBXW4,SLC25A4,RPS3,GNG5,GH1,PIGC,FUT8,PTP4A2,DNAJB9,SEMA5A,BCS1L,TRAPPC6B,TUSC3,RAB39B,SEC11A,COA4,PSMA1,RPL13A,TRAPPC6A,GRPEL1,TUBB4B,SEC22B,UFD1,GOSR2,PREB,MIR197,SUMO3,VAMP2,RPL28,PSMD1,RAB13,MUL1,CD59,CYC1,RAB11B,ST3GAL4,SPCS3,PDCL,CTSD,DYNC1I1,SMAD4,FURIN,ARFGAP1,USP30,SFTPA1,BCL10,ST8SIA4,PGA4,SRPRB,HSPA8,PFDN1,BET1,B4GALT3,DERL2,GFUS,UBE2A,SEC62,RPS27L,PRND,RPS10,ST6GALNAC3,LEP,ADAMTS10,GALNT4,GOSR1,IGFBP3,CTSC,RPL19,B2M,MIR711,EIF2B3,NAPG,ZBTB17,HSPD1,CHCHD3,H2BC17,DPH6,KDELR2,PCGF2,REN,NOP58,H3C1,RNF139,ACTL6A,OTULIN,SPCS1,RAB23,SPON1,RAB31,EIF4H,RAD23B,MGAT4B,H2BC1,ACHE,TOMM7,TOMM20,THY1,MGAT4A,EEF1G,DPH3,HSP90B1,RNF128,WDR20,NFYB,DCTN6,PSME2,NUP107,PTRH2,MME,SMAD1,RAB5C,RPL24,NUS1,EEF1A1,KLF4,RGS6,NEDD8,EIF4A2,PIGK,CGB8,MYC,FAU,RPL32,TADA3,CTSA,EIF5A2,RABGGTB,EXOC1,SRD5A3,UBE2S,SEC13,SMAD3,ERO1A,RPL27,TAF10,CETN2,NFKBIA,SRP14,TUBA1B,RPL29,SFTPD,FBXL3,RPL10A,DCTN4,PSMB3,SCFD1,EIF4E,GNG10,GMDS,SAR1B,RAB35,PSMA5,SEC63,USP14,CHCHD4,EIF3G,DOLK,ATP5F1B,STX1A,H2AC1,GRIA1,TMEM115,RAB6B,RPS13,RAB33A,HSPA5,APEH,BGLAP,RPS27A,RNF146,CMC4,PAX6,UBE2D3,STT3A,H2AC6,TP53,RAB5A,RPS29,USP3,RAB8B,B4GALT1,UBE2I,RIGI,EIF1AX,METTL21A,BRCA1,ATF3,USP5,ENPEP,GALNT2,RAB6A,NLRP3,TOMM40,GPIHBP1,CST3,CCT7,SAMM50,UBE2K,TAFAZZIN,GNAI3,RAB9B,B4GALT4,F7,BECN1,GNAO1,SLC30A5,PLA2G4B,ADRM1,H2AC13,SEC61A1,UBE2N,F10,RPS16,TUBA1A,BABAM1,RPL6,DERL1,H2AB1,GNAZ,ATP5MC1,RPS20,TOP2B,HSCB,UBB,PDIA6,RAB9A,IGF1,RPS9,GALNT12,RPS2,GNG7,TRAPPC2L,UBE2L3,UBE2G2,RPS11,NTNG2,H2BC12,EXOC3,WRAP53,GNG12,RPS15,FKBP8,PSME1,DNAJC19,NFYA,USP8,VDAC2,H2BC11,DAD1,RPL26L1,KIN,SEC61B,PSMB11,DAG1,LY6H,CEACAM5,DCTN3,ST6GAL1,MGAT1,RPL31,FN3KRP,NAPA,BAP1,RAB1A,ADRB2,RAB1B,NUP50,TOMM6,RPL12,CSNK2B,EXOSC4,TIMM10,EDEM3,GHRL,ALG2,RPL27A,CSNK2A1,DYNLL1,GSK3A,SRP54,FBXW7,PSMB9,NANP,B4GAT1,SEC22A,TRAF6,EDEM1,COX19,CDC73,SSR2,RPL7A,RRAGA,ARFGAP3,TIMM8B,SKIC8,SRPRA,EIF4B,PRL,COPZ2,TMED9,PSMD12,CFTR,TNFAIP3,USP2,FPGT,RAB30,RPSA,RNF152,TRAPPC1,RPL37A,GANAB,TMED7,RAD21,RAB14,F2,MSRB3,PML,RPL26,MTX2,RPL39,CHST10,EEF1B2,ST3GAL5,MIA2,PSMD10,GNG13,SPTAN1,ARCN1,PTEN,BACE1,SIAH1,EXOSC8,SENP8,EXOC5,CXXC1,ACTB,TAB1,BIRC5,PROS1,HNRNPC,PSMD4,RAB32,LARGE1,MVD,RPLP1,GPAA1,EIF2S1,CTNNB1,H2AC4,SLC35A1,RPL15,KDELR1,HDAC3,NUP62,B3GNT2,RPS28,RAB33B,SFTPC,GMPPA,LYZ,TIMM23,SHC1,SEC61G,RPN1,RPS5,RPL23A,SUMO1,PSMB2,NUP42,FOLR2,ALG11,GNG11,FOLR1,RPS24,PSMC1,SNX3,DOHH,CXCL8,COG1,SYVN1,TRAPPC4,GALNT1,B4GALT6,MBD5,ST3GAL1,EXOSC1,TMED3,PSMD7,ATP6AP2,GNG2,YIF1A,RAB11A,YKT6,IFIH1,RPL23,CPE,ALPL,USP15,TNKS,SEC61A2,TXN,PSMC5,SLC30A7,MSRB1,TIMM21,PSMB10,POLB,ACO2,SMAD2,UBE2W,EIF3D,MIR7-1,PSMA3,PSMB5,TTR,OS9,PSMD3,UAP1,PSMB7,DNAJC3,FKBP14,TRAM1,NEU1,CCNA2,NUP35,TOMM22,MIR24-1,GNB4,CCT5,CD52,PCNA,RPLP0,RPS26,TNKS2,EXOSC3,ATF4,RPS17,MPDU1,EIF2B2,DPAGT1,IGFBP4,TCP1,PSMD6,GFPT1,RAB37,RPLP2,RPL8,UBE2D1,MITF,INO80C,GNG3,RPS14,KLK3,RNF103,RAB4A,DDIT3,DCP2,PIGA,RAB3D,PFDN2,GNAI2,H2AZ1,EIF5B,JOSD1,H2AC7,TBCE,SEC22C,TGFBR2,UBA52,LY6G6C,GNB1,RAB19,RPS12,VCPKMT,RPL4,EXOC2,RPS23,EP300,PMPCA,OTUD7B,INHA,PIAS1,PFDN6,PFDN4,GCNT3,RPL35,TIMM13,CCT2,EIF3E,RPL17,MAT2B,UCHL3,RPL9,DYNC1I2,STAMBP,RPL18,MDM2,PLG,EIF2B5,DNAJC24,GRPEL2,RAB3A,TRAPPC3,RCE1,RNF40,ARF1,RPL10L,AR,TRAF2,RAB22A,C1GALT1C1,LMAN1,PSMC3,RAB18,ADAMTS1,SEM1,TOP1,ETF1,PSMB4,SEC23A,LHB,ST3GAL2,SPCS2,PSMA6,SSR1,TRAPPC10,ST8SIA5,GNPNAT1,RPL35A,ALG5,SRP72,SLC35C1,GALNT17,STAMBPL1,PDIA3,PHC1,ARF4,EEF2,METTL22,SULT1A3,DPH5,USP13,ITM2B,COX17
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	8.03124829012693e-16	-34.7580215187117	115	78	0.0241560854753794	3229	10285	6165,6734,6152,6731,9789,6746,6147,6130,6158,6745,6208,6128,3921,6224,6229,29927,60559,6217,6122,2197,6161,6176,23478,6191,23521,6235,6729,6175,6207,23471,140801,6157,6233,6181,6132,23480,6193,6184,6231,6138,6218,6234,6146,6747,6139,6188,51121,6134,11224,10952,55176,6143,6136,28972,6133,6160,6141,6206,6187,6155,6124,6205,6228,6168,6129,7311,6203,58477,9349,6209,6159,4736,51065,6154,6201,6727,6170,6204	RPL35A,SRPRA,RPL24,SRP72,SPCS2,SSR2,RPL23A,RPL7A,RPL28,SSR1,RPS14,RPL6,RPSA,RPS20,RPS24,SEC61A1,SPCS3,RPS16,RPL3,FAU,RPL32,RPLP1,SEC11A,RPS4X,RPL13A,RPS29,SRP54,RPLP0,RPS13,TRAM1,RPL10L,RPL27A,RPS27A,RPLP2,RPL8,SEC61G,RPS5,RPN1,RPS26,RPL15,RPS17,RPS28,RPL22,SSR3,RPL17,RPS3,RPL26L1,RPL10,RPL35,SEC61B,SEC61A2,RPL19,RPL12,SPCS1,RPL9,RPL31,RPL18,RPS12,RPS2,RPL27,RPL4,RPS11,RPS23,RPL37A,RPL7,UBA52,RPS9,SRPRB,RPL23,RPS15,RPL29,RPL10A,RPS27L,RPL26,RPS7,SRP14,RPL39,RPS10
R-HSA-156842	Eukaryotic Translation Elongation	1.07738608945934e-12	-27.5564832959604	96	64	0.0198203778259523	3229	10285	6136,6160,6133,6141,6146,6139,6188,51121,11224,6134,6143,9349,6209,6159,4736,6154,51065,6201,6170,6204,1933,6206,6155,6187,6124,6205,6228,6168,7311,6129,6203,3921,6128,6224,6229,6217,6122,2197,1938,6161,6165,6152,1915,6147,6130,6158,6208,6181,6132,6193,1937,6231,6138,6218,6234,6176,6191,23521,6235,6175,6207,140801,6157,6233	RPL12,RPL31,RPL9,RPL18,RPL22,RPL17,RPS3,RPL26L1,RPL35,RPL10,RPL19,RPL23,RPS15,RPL29,RPL10A,RPL26,RPS27L,RPS7,RPL39,RPS10,EEF1B2,RPS12,RPL27,RPS2,RPL4,RPS11,RPS23,RPL37A,UBA52,RPL7,RPS9,RPSA,RPL6,RPS20,RPS24,RPS16,RPL3,FAU,EEF2,RPL32,RPL35A,RPL24,EEF1A1,RPL23A,RPL7A,RPL28,RPS14,RPLP2,RPL8,RPS5,EEF1G,RPS26,RPL15,RPS17,RPS28,RPLP1,RPS4X,RPL13A,RPS29,RPLP0,RPS13,RPL10L,RPL27A,RPS27A
R-HSA-156902	Peptide chain elongation	1.16759725516167e-12	-27.4760731067714	92	62	0.0192009910188913	3229	10285	6152,1915,6165,6208,6147,6130,6158,6224,6128,3921,6122,1938,2197,6161,6229,6217,23521,6235,6175,6176,6191,6157,6233,6207,140801,6132,6193,6181,6218,6234,6231,6138,6139,6188,6146,6143,51121,11224,6134,6136,6133,6160,6141,6205,6228,6206,6187,6155,6124,6129,7311,6203,6168,6159,4736,6209,9349,6170,6204,51065,6154,6201	RPL24,EEF1A1,RPL35A,RPS14,RPL23A,RPL7A,RPL28,RPS20,RPL6,RPSA,RPL3,EEF2,FAU,RPL32,RPS24,RPS16,RPL13A,RPS29,RPLP0,RPLP1,RPS4X,RPL27A,RPS27A,RPS13,RPL10L,RPL8,RPS5,RPLP2,RPS17,RPS28,RPS26,RPL15,RPL17,RPS3,RPL22,RPL19,RPL26L1,RPL35,RPL10,RPL12,RPL9,RPL31,RPL18,RPS11,RPS23,RPS12,RPS2,RPL27,RPL4,RPL7,UBA52,RPS9,RPL37A,RPL29,RPL10A,RPS15,RPL23,RPL39,RPS10,RPS27L,RPL26,RPS7
R-HSA-192823	Viral mRNA Translation	1.16759725516167e-12	-27.4760731067714	92	62	0.0192009910188913	3229	10285	11224,6134,51121,6143,6146,6188,6139,6160,6133,6141,5611,6136,6168,6203,7311,6129,6124,6206,6155,6187,6228,6205,6154,51065,6201,6204,6170,9349,6209,4736,6159,6130,6158,6147,6208,6165,6152,6217,6229,2197,6161,6122,6128,3921,2926,6224,140801,6207,6233,6157,6176,6191,6175,23521,6235,6231,6138,6234,6218,6181,6193,6132	RPL35,RPL10,RPL26L1,RPL19,RPL22,RPS3,RPL17,RPL31,RPL9,RPL18,DNAJC3,RPL12,RPL37A,RPS9,UBA52,RPL7,RPL4,RPS12,RPL27,RPS2,RPS23,RPS11,RPL26,RPS27L,RPS7,RPS10,RPL39,RPL23,RPS15,RPL10A,RPL29,RPL7A,RPL28,RPL23A,RPS14,RPL35A,RPL24,RPS16,RPS24,FAU,RPL32,RPL3,RPL6,RPSA,GRSF1,RPS20,RPL10L,RPS13,RPS27A,RPL27A,RPLP1,RPS4X,RPLP0,RPL13A,RPS29,RPS26,RPL15,RPS28,RPS17,RPLP2,RPS5,RPL8
R-HSA-72613	Eukaryotic Translation Initiation	2.65114984734734e-12	-26.6560276653804	125	77	0.0238463920718489	3229	10285	6224,3921,6128,6122,2197,9669,6161,6229,1974,6217,6152,6165,1975,6208,6147,6130,6158,27335,6132,6193,6181,6218,1964,6234,8892,6231,6138,23521,1965,6235,6175,6176,6191,6157,7458,6233,6207,140801,6136,8669,8893,8664,6160,6133,6141,6139,8891,6188,8666,8894,6146,3646,1977,6143,51121,6134,11224,26986,6159,4736,6209,9349,6170,6204,51065,6201,6154,6205,6228,6206,6187,6155,6124,7311,6129,6203,6168	RPS20,RPSA,RPL6,RPL3,FAU,EIF5B,RPL32,RPS24,EIF4A2,RPS16,RPL24,RPL35A,EIF4B,RPS14,RPL23A,RPL7A,RPL28,EIF3K,RPL8,RPS5,RPLP2,RPS17,EIF1AX,RPS28,EIF2B2,RPS26,RPL15,RPL13A,EIF2S1,RPS29,RPLP0,RPLP1,RPS4X,RPL27A,EIF4H,RPS27A,RPS13,RPL10L,RPL12,EIF3J,EIF2B5,EIF3D,RPL31,RPL9,RPL18,RPL17,EIF2B3,RPS3,EIF3G,EIF2S2,RPL22,EIF3E,EIF4E,RPL19,RPL26L1,RPL10,RPL35,PABPC1,RPL29,RPL10A,RPS15,RPL23,RPL39,RPS10,RPS27L,RPS7,RPL26,RPS11,RPS23,RPS12,RPS2,RPL27,RPL4,UBA52,RPL7,RPS9,RPL37A
R-HSA-72737	Cap-dependent Translation Initiation	2.65114984734734e-12	-26.6560276653804	125	77	0.0238463920718489	3229	10285	6204,6170,6201,51065,6154,4736,6159,6209,9349,6203,7311,6129,6168,6228,6205,6124,6206,6155,6187,6133,6160,6141,8664,8669,6136,8893,1977,6143,11224,6134,26986,51121,6188,8666,8891,6139,3646,8894,6146,1964,8892,6234,6218,6231,6138,6193,6132,6181,6233,6157,7458,140801,6207,6175,23521,1965,6235,6176,6191,2197,6161,9669,6122,6217,6229,1974,6224,3921,6128,6208,6130,6158,27335,6147,6152,1975,6165	RPS10,RPL39,RPS7,RPS27L,RPL26,RPL10A,RPL29,RPS15,RPL23,RPS9,UBA52,RPL7,RPL37A,RPS23,RPS11,RPL4,RPS12,RPL27,RPS2,RPL9,RPL31,RPL18,EIF3D,EIF3J,RPL12,EIF2B5,EIF4E,RPL19,RPL35,RPL10,PABPC1,RPL26L1,RPS3,EIF3G,EIF2B3,RPL17,EIF3E,EIF2S2,RPL22,EIF1AX,EIF2B2,RPS28,RPS17,RPS26,RPL15,RPS5,RPL8,RPLP2,RPS27A,RPL27A,EIF4H,RPL10L,RPS13,RPLP0,RPL13A,EIF2S1,RPS29,RPLP1,RPS4X,FAU,RPL32,EIF5B,RPL3,RPS16,RPS24,EIF4A2,RPS20,RPSA,RPL6,RPS14,RPL7A,RPL28,EIF3K,RPL23A,RPL24,EIF4B,RPL35A
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	3.98926663854276e-12	-26.247413701784	117	73	0.0226076184577268	3229	10285	6168,6203,6129,7311,6124,6187,6155,6206,6228,6205,6201,51065,6154,6204,6170,9349,6209,4736,6159,26986,11224,6134,51121,1977,6143,3646,6146,8894,8666,6188,6139,6141,6133,6160,8664,8669,6136,140801,6207,6233,7458,6157,6191,6176,6175,6235,1965,23521,6138,6231,6234,1964,6218,6181,6193,6132,6158,27335,6130,6147,6208,1975,6165,6152,6217,6229,1974,6161,2197,6122,3921,6128,6224	RPL37A,RPS9,RPL7,UBA52,RPL4,RPS2,RPL27,RPS12,RPS23,RPS11,RPS7,RPS27L,RPL26,RPS10,RPL39,RPL23,RPS15,RPL10A,RPL29,PABPC1,RPL35,RPL10,RPL26L1,EIF4E,RPL19,EIF3E,RPL22,EIF2S2,EIF3G,RPS3,RPL17,RPL18,RPL9,RPL31,EIF3D,EIF3J,RPL12,RPL10L,RPS13,RPS27A,EIF4H,RPL27A,RPS4X,RPLP1,RPLP0,RPS29,EIF2S1,RPL13A,RPL15,RPS26,RPS28,EIF1AX,RPS17,RPLP2,RPS5,RPL8,RPL28,EIF3K,RPL7A,RPL23A,RPS14,EIF4B,RPL35A,RPL24,RPS16,RPS24,EIF4A2,RPL32,FAU,RPL3,RPSA,RPL6,RPS20
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	3.98926663854276e-12	-26.247413701784	117	73	0.0226076184577268	3229	10285	6136,8669,8664,6141,6160,6133,6139,8666,6188,6146,8894,3646,6143,1977,51121,11224,6134,6159,4736,6209,9349,6170,6204,6201,51065,6154,6205,6228,6187,6155,6206,6124,6129,7311,6203,6168,6224,6128,3921,6122,6161,9669,2197,1974,6229,6217,6152,6165,1975,6208,6147,6130,6158,27335,6132,6193,6181,6218,6234,1964,6138,6231,6235,1965,23521,6175,6191,6176,7458,6157,6233,6207,140801	RPL12,EIF3J,EIF3D,RPL18,RPL31,RPL9,RPL17,EIF3G,RPS3,RPL22,EIF2S2,EIF3E,RPL19,EIF4E,RPL26L1,RPL35,RPL10,RPL29,RPL10A,RPS15,RPL23,RPL39,RPS10,RPS7,RPS27L,RPL26,RPS11,RPS23,RPS2,RPL27,RPS12,RPL4,RPL7,UBA52,RPS9,RPL37A,RPS20,RPL6,RPSA,RPL3,RPL32,EIF5B,FAU,EIF4A2,RPS24,RPS16,RPL24,RPL35A,EIF4B,RPS14,RPL23A,RPL7A,RPL28,EIF3K,RPL8,RPS5,RPLP2,RPS17,RPS28,EIF1AX,RPL15,RPS26,RPS29,EIF2S1,RPL13A,RPLP0,RPS4X,RPLP1,EIF4H,RPL27A,RPS27A,RPS13,RPL10L
R-HSA-72764	Eukaryotic Translation Termination	4.69790002731674e-12	-26.0839055097572	96	63	0.0195106844224218	3229	10285	6141,6133,6160,51504,6136,51121,6134,11224,6143,6146,6139,6188,51065,6154,6201,6170,6204,9349,6209,6159,4736,6168,7311,6129,6203,6155,6187,6206,6124,6205,6228,6229,6217,6122,6161,2197,3921,6128,6224,6147,6158,6130,6208,6165,6152,6138,6231,6218,6234,2107,6181,6132,6193,6207,140801,327,6157,6233,6191,6176,6235,23521,6175	RPL18,RPL9,RPL31,TRMT112,RPL12,RPL26L1,RPL10,RPL35,RPL19,RPL22,RPL17,RPS3,RPS27L,RPL26,RPS7,RPL39,RPS10,RPL23,RPS15,RPL29,RPL10A,RPL37A,UBA52,RPL7,RPS9,RPL27,RPS2,RPS12,RPL4,RPS11,RPS23,RPS24,RPS16,RPL3,RPL32,FAU,RPSA,RPL6,RPS20,RPL23A,RPL28,RPL7A,RPS14,RPL35A,RPL24,RPL15,RPS26,RPS17,RPS28,ETF1,RPLP2,RPL8,RPS5,RPS13,RPL10L,APEH,RPL27A,RPS27A,RPS4X,RPLP1,RPS29,RPL13A,RPLP0
R-HSA-72689	Formation of a pool of free 40S subunits	2.65803771899401e-11	-24.3508478720015	105	66	0.0204397646330133	3229	10285	6139,6188,8666,6146,3646,6143,51121,6134,11224,6136,8669,8664,6133,6160,6141,6205,6228,6206,6155,6187,6124,7311,6129,6203,6168,6159,4736,6209,9349,6170,6204,6154,6201,51065,6152,6165,6208,6147,6130,27335,6158,6224,6128,3921,6122,2197,6161,6229,6217,23521,6235,6175,6176,6191,6157,6233,6207,140801,6132,6193,6181,6218,1964,6234,6231,6138	RPL17,RPS3,EIF3G,RPL22,EIF3E,RPL19,RPL26L1,RPL10,RPL35,RPL12,EIF3J,EIF3D,RPL9,RPL31,RPL18,RPS11,RPS23,RPS12,RPL27,RPS2,RPL4,UBA52,RPL7,RPS9,RPL37A,RPL29,RPL10A,RPS15,RPL23,RPL39,RPS10,RPL26,RPS7,RPS27L,RPL24,RPL35A,RPS14,RPL23A,RPL7A,EIF3K,RPL28,RPS20,RPL6,RPSA,RPL3,FAU,RPL32,RPS24,RPS16,RPL13A,RPS29,RPLP0,RPLP1,RPS4X,RPL27A,RPS27A,RPS13,RPL10L,RPL8,RPS5,RPLP2,RPS17,EIF1AX,RPS28,RPS26,RPL15
R-HSA-72163	mRNA Splicing - Major Pathway	3.23371370559201e-11	-24.1548047921077	187	102	0.0315887271601115	3229	10285	3183,1665,22826,3185,22794,10465,10421,3184,27258,6429,51503,4116,26121,8449,6638,10949,5431,6434,23451,2963,6628,10084,5436,5546,23398,57794,10291,1993,9785,6629,10978,53981,5432,10262,24144,10285,6625,3188,55110,1655,22916,10914,6634,10713,6635,10907,6633,11157,23658,57819,25804,51362,6936,3191,6426,8896,693221,83443,407043,6627,6632,3181,10898,27339,23283,100302196,65109,9416,100126351,5435,11325,5433,5441,51729,3312,6637,9128,9775,3190,10189,9879,6432,51691,6427,10772,11017,988,5438,6626,2962,1660,55696,10181,3178,1479,10569,51639,56259,29894,84991,9410,55749	HNRNPC,DHX15,DNAJC8,HNRNPF,CASC3,PPIH,CD2BP2,HNRNPD,LSM3,SRSF4,CWC15,MAGOH,PRPF31,DHX16,SNRPN,HNRNPA0,POLR2B,TRA2B,SF3B1,GTF2F2,SNRPB,PQBP1,POLR2G,PRCC,PPWD1,SUGP1,SF3A1,ELAVL2,DHX38,SNRPB2,CLP1,CPSF2,POLR2C,SF3B4,TFIP11,SMNDC1,SNRNP70,HNRNPH2,MAGOHB,DDX5,NCBP2,PAPOLA,SNRPD3,USP39,SNRPE,TXNL4A,SNRPD2,LSM6,LSM5,LSM2,LSM4,CDC40,GCFC2,HNRNPL,SRSF1,BUD31,MIR636,SF3B5,MIR7-1,SNRPA1,SNRPD1,HNRNPA2B1,CPSF4,PRPF19,CSTF2T,MIR1234,UPF3B,DDX23,MIR939,POLR2F,DDX42,POLR2D,POLR2L,WBP11,HSPA8,SNRPG,PRPF4,EIF4A3,HNRNPK,ALYREF,DDX46,SRSF7,LSM8,SRSF2,SRSF10,SNRNP27,CDC5L,POLR2I,SNRPA,GTF2F1,DHX9,RBM22,RBM5,HNRNPA1,CSTF3,SLU7,SF3B6,CTNNBL1,CPSF1,RBM17,SNRNP40,CCAR1
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	3.47267522441336e-11	-24.083510767967	99	63	0.0195106844224218	3229	10285	140801,6207,6233,6157,6176,6191,6175,23521,6235,6231,6138,22916,6234,6218,6181,2107,6193,6132,6158,6130,6147,6208,6165,6152,6217,6229,2197,6161,6122,3921,6128,6224,6168,6203,7311,6129,6124,6206,6187,6155,6228,6205,51065,6201,6154,6204,6170,9349,6209,4736,6159,6134,11224,26986,51121,6143,6146,6188,6139,6160,6133,6141,6136	RPL10L,RPS13,RPS27A,RPL27A,RPLP1,RPS4X,RPLP0,RPL13A,RPS29,RPS26,RPL15,NCBP2,RPS28,RPS17,RPLP2,ETF1,RPS5,RPL8,RPL28,RPL7A,RPL23A,RPS14,RPL35A,RPL24,RPS16,RPS24,FAU,RPL32,RPL3,RPSA,RPL6,RPS20,RPL37A,RPS9,UBA52,RPL7,RPL4,RPS12,RPS2,RPL27,RPS23,RPS11,RPS27L,RPS7,RPL26,RPS10,RPL39,RPL23,RPS15,RPL10A,RPL29,RPL10,RPL35,PABPC1,RPL26L1,RPL19,RPL22,RPS3,RPL17,RPL31,RPL9,RPL18,RPL12
R-HSA-72172	mRNA Splicing	4.66624026141539e-11	-23.7880823587159	195	105	0.032517807370703	3229	10285	10465,10421,22794,3185,1665,22826,3183,6638,8449,51503,4116,26121,6429,27258,3184,5431,10949,23398,85437,5436,5546,2963,10084,6628,6434,23451,6629,9785,1993,10291,57794,6625,10285,24144,10262,5432,10978,53981,10713,22916,10914,6634,55110,1655,3188,11157,23658,6633,6635,10907,407043,83443,693221,8896,6426,3191,51362,6936,57819,25804,27339,23283,100302196,10898,3181,6627,6632,100126351,9416,65109,9128,55954,3312,6637,5433,51729,5441,11325,5435,51691,6432,6427,10772,9879,10189,9775,3190,1660,6626,2962,988,5438,11017,10569,3178,1479,10181,55696,55749,9410,154007,84991,51639,29894,56259	PPIH,CD2BP2,CASC3,HNRNPF,DHX15,DNAJC8,HNRNPC,SNRPN,DHX16,CWC15,MAGOH,PRPF31,SRSF4,LSM3,HNRNPD,POLR2B,HNRNPA0,PPWD1,ZCRB1,POLR2G,PRCC,GTF2F2,PQBP1,SNRPB,TRA2B,SF3B1,SNRPB2,DHX38,ELAVL2,SF3A1,SUGP1,SNRNP70,SMNDC1,TFIP11,SF3B4,POLR2C,CLP1,CPSF2,USP39,NCBP2,PAPOLA,SNRPD3,MAGOHB,DDX5,HNRNPH2,LSM6,LSM5,SNRPD2,SNRPE,TXNL4A,MIR7-1,SF3B5,MIR636,BUD31,SRSF1,HNRNPL,CDC40,GCFC2,LSM2,LSM4,PRPF19,CSTF2T,MIR1234,CPSF4,HNRNPA2B1,SNRPA1,SNRPD1,MIR939,DDX23,UPF3B,PRPF4,ZMAT5,HSPA8,SNRPG,POLR2D,WBP11,POLR2L,DDX42,POLR2F,LSM8,SRSF7,SRSF2,SRSF10,DDX46,ALYREF,EIF4A3,HNRNPK,DHX9,SNRPA,GTF2F1,CDC5L,POLR2I,SNRNP27,SLU7,HNRNPA1,CSTF3,RBM5,RBM22,CCAR1,SNRNP40,SNRNP48,RBM17,SF3B6,CPSF1,CTNNBL1
R-HSA-1236974	ER-Phagosome pathway	5.74510046323691e-11	-23.5800886247132	85	56	0.0173428305977083	3229	10285	5716,948,5720,7096,9341,5713,10213,8673,7311,7099,7314,5695,8773,5709,5689,5693,5684,5704,10333,5685,5686,5699,23643,567,5705,122706,5694,5683,55176,10952,5691,5721,23480,7097,3551,5692,9861,7979,929,5698,4615,9554,5702,5682,6233,5710,114609,811,5700,29927,5718,2923,6892,5707,5690,5687	PSMD10,CD36,PSME1,TLR1,VAMP3,PSMD7,PSMD14,VAMP8,UBA52,TLR4,UBB,PSMB7,SNAP23,PSMD3,PSMB1,PSMB5,PSMA3,PSMC4,TLR6,PSMA4,PSMA5,PSMB10,LY96,B2M,PSMC5,PSMB11,PSMB6,PSMA2,SEC61A2,SEC61B,PSMB3,PSME2,SEC61G,TLR2,IKBKB,PSMB4,PSMD6,SEM1,CD14,PSMB9,MYD88,SEC22B,PSMC3,PSMA1,RPS27A,PSMD4,TIRAP,CALR,PSMC1,SEC61A1,PSMD12,PDIA3,TAPBP,PSMD1,PSMB2,PSMA6
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	7.07228224126615e-11	-23.3722527887142	247	126	0.0390213688448436	3229	10285	9410,129401,55749,51639,29894,56259,154007,84991,10569,9972,3178,1479,29107,55696,10181,6626,2962,79228,5438,988,57122,1660,11017,9879,51691,6432,10772,6427,9775,3190,79023,10189,3312,6637,5433,5441,51729,9128,55954,5435,11325,100126351,65109,9416,9984,27339,23283,100302196,10898,6627,6632,3181,8896,693221,407043,83443,57819,25804,10762,6426,3191,51362,6936,23658,11157,6633,6635,10907,84321,23636,84271,10713,7919,22916,6634,10914,3188,55110,1655,26097,57187,24144,11097,10262,6625,10285,57721,5432,53981,10978,6629,9785,10212,10291,57794,1993,23398,85437,6434,23451,5436,5546,84248,10084,6628,2963,10949,9589,5431,1977,8449,4116,51503,26121,6638,3184,9877,6429,27258,22794,3185,10421,10465,3183,1665,22826	SNRNP40,NUP35,CCAR1,SF3B6,CPSF1,CTNNBL1,SNRNP48,RBM17,SLU7,NUP153,HNRNPA1,CSTF3,NXT1,RBM22,RBM5,SNRPA,GTF2F1,THOC6,POLR2I,CDC5L,NUP107,DHX9,SNRNP27,DDX46,LSM8,SRSF7,SRSF10,SRSF2,EIF4A3,HNRNPK,NUP37,ALYREF,HSPA8,SNRPG,POLR2D,POLR2L,WBP11,PRPF4,ZMAT5,POLR2F,DDX42,MIR939,UPF3B,DDX23,THOC1,PRPF19,CSTF2T,MIR1234,CPSF4,SNRPA1,SNRPD1,HNRNPA2B1,BUD31,MIR636,MIR7-1,SF3B5,LSM2,LSM4,NUP50,SRSF1,HNRNPL,CDC40,GCFC2,LSM5,LSM6,SNRPD2,SNRPE,TXNL4A,THOC3,NUP62,POLDIP3,USP39,DDX39B,NCBP2,SNRPD3,PAPOLA,HNRNPH2,MAGOHB,DDX5,CHTOP,THOC2,TFIP11,NUP42,SF3B4,SNRNP70,SMNDC1,METTL14,POLR2C,CPSF2,CLP1,SNRPB2,DHX38,DDX39A,SF3A1,SUGP1,ELAVL2,PPWD1,ZCRB1,TRA2B,SF3B1,POLR2G,PRCC,FYTTD1,PQBP1,SNRPB,GTF2F2,HNRNPA0,WTAP,POLR2B,EIF4E,DHX16,MAGOH,CWC15,PRPF31,SNRPN,HNRNPD,ZC3H11A,SRSF4,LSM3,CASC3,HNRNPF,CD2BP2,PPIH,HNRNPC,DHX15,DNAJC8
R-HSA-927802	Nonsense-Mediated Decay (NMD)	7.95125883454887e-11	-23.2551057628349	120	72	0.0222979250541963	3229	10285	6132,6193,6181,55110,2107,6218,6234,22916,6231,6138,23521,6235,6175,56006,6176,6191,6157,6233,6207,140801,9775,6224,6128,3921,6122,2197,6161,6229,6217,23381,6152,6165,6208,6147,6158,6130,6159,65109,4736,9349,6209,6170,55181,6204,6201,6154,51065,6205,6228,6206,6155,6187,6124,6129,7311,6203,6168,5518,6136,22794,6160,6133,6141,6139,6188,6146,4116,6143,51121,6134,11224,26986	RPL8,RPS5,RPLP2,MAGOHB,ETF1,RPS17,RPS28,NCBP2,RPS26,RPL15,RPL13A,RPS29,RPLP0,SMG9,RPLP1,RPS4X,RPL27A,RPS27A,RPS13,RPL10L,EIF4A3,RPS20,RPL6,RPSA,RPL3,FAU,RPL32,RPS24,RPS16,SMG5,RPL24,RPL35A,RPS14,RPL23A,RPL28,RPL7A,RPL29,UPF3B,RPL10A,RPL23,RPS15,RPL39,SMG8,RPS10,RPS7,RPL26,RPS27L,RPS11,RPS23,RPS12,RPL27,RPS2,RPL4,RPL7,UBA52,RPS9,RPL37A,PPP2R1A,RPL12,CASC3,RPL31,RPL9,RPL18,RPL17,RPS3,RPL22,MAGOH,RPL19,RPL26L1,RPL10,RPL35,PABPC1
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	7.95125883454887e-11	-23.2551057628349	120	72	0.0222979250541963	3229	10285	6165,6152,6147,6130,6158,6208,3921,6128,6224,9775,6229,23381,6217,6122,6161,2197,56006,6191,6176,6235,23521,6175,6207,140801,6157,6233,55110,2107,6181,6132,6193,22916,6138,6231,6218,6234,6146,6139,6188,51121,26986,6134,11224,4116,6143,6136,6141,6133,6160,22794,6187,6155,6206,6124,6205,6228,5518,6168,6129,7311,6203,6209,9349,65109,6159,4736,6154,6201,51065,55181,6170,6204	RPL35A,RPL24,RPL23A,RPL7A,RPL28,RPS14,RPSA,RPL6,RPS20,EIF4A3,RPS24,SMG5,RPS16,RPL3,RPL32,FAU,SMG9,RPS4X,RPLP1,RPS29,RPL13A,RPLP0,RPS13,RPL10L,RPL27A,RPS27A,MAGOHB,ETF1,RPLP2,RPL8,RPS5,NCBP2,RPL15,RPS26,RPS17,RPS28,RPL22,RPL17,RPS3,RPL26L1,PABPC1,RPL10,RPL35,MAGOH,RPL19,RPL12,RPL18,RPL9,RPL31,CASC3,RPS2,RPL27,RPS12,RPL4,RPS11,RPS23,PPP2R1A,RPL37A,RPL7,UBA52,RPS9,RPS15,RPL23,UPF3B,RPL29,RPL10A,RPL26,RPS7,RPS27L,SMG8,RPL39,RPS10
R-HSA-1643685	Disease	1.21362623955962e-10	-22.8322381598633	858	354	0.109631464849799	3229	10285	5606,26127,27249,9844,79872,5441,3516,5433,6776,5435,10213,6048,5781,6648,7852,5704,5689,5694,5683,5685,2260,9972,92421,9146,213,55750,4296,572,6191,292,811,6122,79023,51160,5901,5610,7098,7520,2962,80070,5507,7096,6201,948,81793,27006,6129,4000,6917,3845,2963,11044,5296,3326,5052,6134,51107,6188,291,51135,4233,4790,6146,928,9037,23521,8905,5682,1234,4089,653509,5045,5608,5707,10013,3320,5290,207,6158,6844,9899,5432,6204,8822,7750,941,51065,23385,8805,81794,8322,5664,2966,7099,51009,6921,1027,2817,1385,60489,5295,1500,6143,1445,8315,7001,940,2957,8815,567,3725,79885,4615,5721,2960,27243,10418,2197,6161,4609,4793,10014,920,8503,5438,1173,6772,57122,1452,148022,1175,6152,5478,4792,6873,4969,4736,5091,6441,3767,6159,6714,6881,6879,6827,5436,31,4088,6155,2239,7529,166785,6804,27248,10333,6616,29851,160,919,5037,5691,356,5686,4040,22916,6233,6207,6235,942,7450,8323,823,6217,2071,55851,6224,8823,6128,79139,1024,3815,51534,2968,4594,2961,5549,5720,6209,1022,6203,1487,2280,5518,5902,7314,6205,6187,6160,3717,4853,6136,10762,25974,51121,7100,1605,23643,122706,5698,6829,55294,2248,6157,2931,2997,1080,5718,8851,2926,3921,6130,7514,2237,208,4331,6170,6154,5431,5716,5096,6168,5894,5604,9636,2246,51510,7296,6234,8841,23636,6138,9525,6193,6464,3551,7097,5062,6440,3417,404672,5710,5245,1499,6176,6880,2959,5700,1387,6229,1025,5690,11097,6147,5516,3265,3159,7251,6383,4060,553,5713,6385,6500,9349,867,84447,8907,7276,57085,5693,5684,5695,5611,5709,10956,1020,10898,8658,4087,5699,5705,6218,6231,80351,25978,6132,1839,6181,9861,129401,6175,2252,114609,10613,3838,1026,6208,824,5906,127833,2255,118788,2331,2033,3836,55109,7311,7048,10533,6228,5908,6124,2958,6206,4193,6133,6141,5525,375,22943,5529,11224,6139,902,8074,7979,929,9510,5692,140801,11160,4001,5702,1938,6882,6843,6749,1185,10000,5687,23493,2549,6165,27183	MAP2K3,FGFR1OP2,MMADHC,ELMO1,CBLL1,POLR2L,RBPJ,POLR2D,STAT5A,POLR2F,PSMD14,RNF5,PTPN11,SOD2,CXCR4,PSMC4,PSMB1,PSMB6,PSMA2,PSMA4,FGFR1,NUP153,CHMP4C,HGS,ALB,AGK,MAP3K11,BAD,RPS4X,SLC25A5,CALR,RPL3,NUP37,VPS28,RAN,EIF2AK2,TLR3,XRCC5,GTF2F1,ADAMTS20,PPP1R3C,TLR1,RPS7,CD36,TLR10,FGF22,RPL7,LMNA,TCEA1,KRAS,GTF2F2,TENT4A,PIK3R2,HSP90AB1,PRDX1,RPL10,APH1A,RPS3,SLC25A4,IRAK4,MET,NFKB1,RPL22,CD9,SEMA5A,RPL13A,AP1S2,PSMA1,CCR5,SMAD4,SFTPA1,FURIN,MAP2K6,PSMD1,HDAC6,HSP90AA1,PIK3CA,AKT1,RPL28,VAMP2,SV2B,POLR2C,RPS10,FGF17,ZMYM2,CD80,RPS27L,NCSTN,TRIM24,ADAMTS10,FZD4,PSEN2,GTF2H2,TLR4,DERL2,ELOC,CDKN1B,GPC1,CREB1,APOBEC3G,PIK3R1,CTNND1,RPL19,CSK,BRAP,PRDX2,CD28,GTF2A1,BANF1,B2M,JUN,HDAC11,MYD88,PSME2,GTF2E1,CHMP2A,SPON1,FAU,RPL32,MYC,NFKBIB,HDAC5,CD4,PIK3R3,POLR2I,AP2M1,STAT1,NUP107,CSNK1A1,TICAM1,AP2S1,RPL24,PPIA,NFKBIA,TAF2,OGN,RPL10A,PC,SFTPD,KCNJ11,RPL29,SRC,TAF10,TAF7,SUPT4H1,POLR2G,ACACA,SMAD3,RPL27,GPC4,YWHAB,MMAA,STX1A,ERLEC1,TLR6,SNAP25,ICOS,AP2A1,CD247,PEBP1,PSMB3,FASLG,PSMA5,LRP6,NCBP2,RPS27A,RPS13,RPS29,CD86,VWF,FZD6,CAPN1,RPS16,ERCC3,PSENEN,RPS20,FGF16,RPL6,DERL1,CDK8,KIT,VTA1,GTF2H4,MMUT,GTF2E2,PRELP,PSME1,RPS15,CDK7,RPS9,CTBP1,FKBP1A,PPP2R1A,RANBP1,UBB,RPS11,RPS2,RPL31,JAK2,NOTCH2,RPL12,NUP50,MMACHC,RPL26L1,TLR5,DAG1,LY96,PSMB11,PSMB9,SUPT5H,FBXW7,FGF3,RPL27A,GSK3A,GYS1,CFTR,PSMD12,CDK5R1,GRSF1,RPSA,RPL7A,XPO1,FEN1,AKT2,MNAT1,RPL39,RPL26,POLR2B,PSMD10,PCCB,RPL37A,RAF1,MAP2K1,ISG15,FGF1,CHMP5,TXNRD1,RPS28,HDAC3,NUP62,RPL15,VPS4B,RPS5,SHC1,IKBKB,TLR2,PAK2,SFTPC,IDH1,GTF2H5,PSMD4,PHB1,CTNNB1,RPLP1,TAF9,GTF2B,PSMC1,CREBBP,RPS24,CDK9,PSMB2,NUP42,RPL23A,PPP2CB,HRAS,HMGA1,TSG101,SDC2,LUM,AVPR1B,PSMD7,SDC4,SKP1,RPL23,CBL,SYVN1,AP1M1,TTR,AGTRAP,PSMB5,PSMA3,PSMB7,DNAJC3,PSMD3,OS9,CDK5,CPSF4,TNKS,SMAD2,PSMB10,PSMC5,RPS17,RPS26,TNKS2,CHMP2B,RPL8,HBEGF,RPLP2,PSMD6,NUP35,RPLP0,FGF7,TIRAP,ERLIN1,KPNA2,CDKN1A,RPS14,CAPN2,RAP1A,SYT2,FGF10,PIK3AP1,FMOD,EP300,KPNA1,AGGF1,UBA52,TGFBR2,ATG7,RPS23,RAP1B,RPL4,GTF2A2,RPS12,MDM2,RPL9,RPL18,PPP2R5A,ARF1,DKK1,PPP2R5E,RPL35,RPL17,CCNH,FGF23,SEM1,CD14,ADAMTS1,PSMB4,RPL10L,ERLIN2,LMNB1,PSMC3,EEF2,TAF11,VAMP1,SSRP1,CLCN6,AKT3,PSMA6,HEY2,GAB1,RPL35A,VPS4A
R-HSA-168255	Influenza Life Cycle	1.41036106489041e-10	-22.6820051839415	146	83	0.0257045524930319	3229	10285	4736,6159,3836,6209,9349,6204,6170,51065,6201,6154,5431,5435,6228,6205,6124,5436,2963,6206,6187,6155,6203,5441,5433,6129,7311,6168,5611,6136,10762,6160,6133,6141,6188,6139,6146,6143,6134,11224,51121,6193,6132,6181,6234,9972,6218,23636,6231,6138,6175,23521,6235,6176,6191,6233,129401,6157,140801,6207,2926,79023,6224,6128,5901,3921,2197,6161,811,6122,6217,6229,6152,5432,6165,2962,6208,5438,11097,3320,57122,6130,7514,6158,6147	RPL10A,RPL29,KPNA1,RPS15,RPL23,RPS10,RPL39,RPS27L,RPS7,RPL26,POLR2B,POLR2F,RPS23,RPS11,RPL4,POLR2G,GTF2F2,RPS12,RPS2,RPL27,RPS9,POLR2L,POLR2D,RPL7,UBA52,RPL37A,DNAJC3,RPL12,NUP50,RPL31,RPL9,RPL18,RPS3,RPL17,RPL22,RPL19,RPL10,RPL35,RPL26L1,RPS5,RPL8,RPLP2,RPS28,NUP153,RPS17,NUP62,RPS26,RPL15,RPLP0,RPL13A,RPS29,RPLP1,RPS4X,RPS27A,NUP35,RPL27A,RPL10L,RPS13,GRSF1,NUP37,RPS20,RPL6,RAN,RPSA,FAU,RPL32,CALR,RPL3,RPS16,RPS24,RPL24,POLR2C,RPL35A,GTF2F1,RPS14,POLR2I,NUP42,HSP90AA1,NUP107,RPL7A,XPO1,RPL28,RPL23A
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	1.50431326323146e-10	-22.6175144393784	76	51	0.0157943635800557	3229	10285	5698,7979,9232,29945,5721,7321,9861,29882,25906,5692,8697,6233,5710,890,51529,5702,5682,119504,5718,891,5700,5707,5690,4085,5687,5713,5716,983,5720,246184,7311,7314,10213,4751,5693,5684,5704,5709,8881,5695,991,5689,5683,5694,9184,5691,5685,122706,5705,5686,5699	PSMB9,SEM1,PTTG1,ANAPC4,PSME2,UBE2D1,PSMD6,ANAPC2,ANAPC15,PSMB4,CDC23,RPS27A,PSMD4,CCNA2,ANAPC11,PSMC3,PSMA1,ANAPC16,PSMD12,CCNB1,PSMC1,PSMD1,PSMB2,MAD2L1,PSMA6,PSMD7,PSMD10,CDK1,PSME1,CDC26,UBA52,UBB,PSMD14,NEK2,PSMB5,PSMA3,PSMC4,PSMD3,CDC16,PSMB7,CDC20,PSMB1,PSMA2,PSMB6,BUB3,PSMB3,PSMA4,PSMB11,PSMC5,PSMA5,PSMB10
R-HSA-168273	Influenza Viral RNA Transcription and Replication	1.52068218493663e-10	-22.6066918898861	137	79	0.0244657788789099	3229	10285	11097,5438,6208,2962,6147,6130,6158,57122,3320,6152,6165,5432,6122,6161,2197,6229,6217,79023,6224,2926,3921,6128,6157,129401,6233,6207,140801,6235,23521,6175,6191,6176,23636,6218,6234,9972,6138,6231,6132,6193,6181,6143,51121,11224,6134,6139,6188,6146,6141,6133,6160,6136,5611,10762,5433,7311,6129,5441,6203,6168,6205,5435,6228,6187,6155,6206,2963,6124,5436,6170,6204,5431,6154,51065,6201,6159,4736,9349,6209	NUP42,POLR2I,RPS14,GTF2F1,RPL23A,RPL7A,RPL28,NUP107,HSP90AA1,RPL24,RPL35A,POLR2C,RPL3,RPL32,FAU,RPS24,RPS16,NUP37,RPS20,GRSF1,RPSA,RPL6,RPL27A,NUP35,RPS27A,RPS13,RPL10L,RPS29,RPL13A,RPLP0,RPS4X,RPLP1,NUP62,RPS17,RPS28,NUP153,RPL15,RPS26,RPL8,RPS5,RPLP2,RPL19,RPL26L1,RPL35,RPL10,RPL17,RPS3,RPL22,RPL18,RPL9,RPL31,RPL12,DNAJC3,NUP50,POLR2D,UBA52,RPL7,POLR2L,RPS9,RPL37A,RPS11,POLR2F,RPS23,RPS2,RPL27,RPS12,GTF2F2,RPL4,POLR2G,RPL39,RPS10,POLR2B,RPL26,RPS27L,RPS7,RPL29,RPL10A,RPL23,RPS15
R-HSA-2408557	Selenocysteine synthesis	1.60219136005489e-10	-22.5544786377071	95	60	0.0185816042118303	3229	10285	9349,6209,6159,4736,6154,51065,6201,6170,6204,6187,6155,6206,6124,6205,6228,6168,7311,6129,6203,6136,6141,6160,6133,6146,6139,6188,51121,11224,6134,6143,6181,6132,6193,6138,6231,6218,6234,6191,6176,6235,23521,6175,6207,140801,6157,6233,3921,6128,6224,6229,6217,6122,6161,2197,6165,6152,6147,6158,6130,6208	RPL23,RPS15,RPL29,RPL10A,RPL26,RPS27L,RPS7,RPL39,RPS10,RPS2,RPL27,RPS12,RPL4,RPS11,RPS23,RPL37A,UBA52,RPL7,RPS9,RPL12,RPL18,RPL31,RPL9,RPL22,RPL17,RPS3,RPL26L1,RPL35,RPL10,RPL19,RPLP2,RPL8,RPS5,RPL15,RPS26,RPS17,RPS28,RPS4X,RPLP1,RPS29,RPL13A,RPLP0,RPS13,RPL10L,RPL27A,RPS27A,RPSA,RPL6,RPS20,RPS24,RPS16,RPL3,RPL32,FAU,RPL35A,RPL24,RPL23A,RPL28,RPL7A,RPS14
R-HSA-69202	Cyclin E associated events during G1/S transition	1.60680104770915e-10	-22.5516056543907	72	49	0.0151749767729947	3229	10285	207,10000,5687,5690,5707,208,5718,5700,4609,1026,5710,1163,890,6233,5682,5702,4149,5698,7979,9861,5692,5721,5691,5683,5694,5705,5699,5686,902,5685,1027,5704,1019,5693,5684,5689,5709,5695,7314,7311,10213,5925,5713,4331,6500,1022,595,5720,5716	AKT1,AKT3,PSMA6,PSMB2,PSMD1,AKT2,PSMD12,PSMC1,MYC,CDKN1A,PSMD4,CKS1B,CCNA2,RPS27A,PSMA1,PSMC3,MAX,PSMB9,SEM1,PSMD6,PSMB4,PSME2,PSMB3,PSMA2,PSMB6,PSMC5,PSMB10,PSMA5,CCNH,PSMA4,CDKN1B,PSMC4,CDK4,PSMB5,PSMA3,PSMB1,PSMD3,PSMB7,UBB,UBA52,PSMD14,RB1,PSMD7,MNAT1,SKP1,CDK7,CCND1,PSME1,PSMD10
R-HSA-168254	Influenza Infection	3.09659054206778e-10	-21.8955492488403	157	87	0.0269433261071539	3229	10285	5432,6165,6158,3320,6147,11097,6128,6224,6217,6229,6176,6235,23521,140801,6207,6233,6193,6138,6234,23636,6146,6188,6139,6134,11224,6141,6133,9636,5436,6124,6155,2963,6206,6228,6168,6129,7311,3836,4736,6159,6201,6154,5431,6170,6152,7514,6130,57122,6208,2962,5438,3921,5610,5901,79023,2926,6161,2197,6122,811,3838,6191,6175,6157,129401,6181,6132,6231,9972,6218,10898,51121,6143,10762,5611,6136,6160,6187,5435,6205,6203,5433,5441,6209,9349,51065,6204	POLR2C,RPL35A,RPL28,HSP90AA1,RPL23A,NUP42,RPL6,RPS20,RPS16,RPS24,RPLP1,RPS29,RPL13A,RPL10L,RPS13,RPS27A,RPS5,RPL15,RPS28,NUP62,RPL22,RPS3,RPL17,RPL10,RPL35,RPL18,RPL9,ISG15,POLR2G,RPL4,RPL27,GTF2F2,RPS12,RPS23,RPL37A,RPL7,UBA52,KPNA1,RPL10A,RPL29,RPS7,RPL26,POLR2B,RPL39,RPL24,XPO1,RPL7A,NUP107,RPS14,GTF2F1,POLR2I,RPSA,EIF2AK2,RAN,NUP37,GRSF1,RPL32,FAU,RPL3,CALR,KPNA2,RPS4X,RPLP0,RPL27A,NUP35,RPLP2,RPL8,RPS26,NUP153,RPS17,CPSF4,RPL26L1,RPL19,NUP50,DNAJC3,RPL12,RPL31,RPS2,POLR2F,RPS11,RPS9,POLR2D,POLR2L,RPS15,RPL23,RPS27L,RPS10
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	3.10181235298227e-10	-21.8938643592846	77	51	0.0157943635800557	3229	10285	5713,5720,983,5716,7314,246184,7311,10213,5704,5693,5684,4751,5689,991,5695,8881,5709,5691,9184,5694,5683,5686,5699,5705,122706,5685,29945,9232,7979,5698,8697,5692,25906,29882,9861,5721,7321,890,51529,5710,6233,5682,5702,5700,891,5718,119504,5687,4085,5690,5707	PSMD7,PSME1,CDK1,PSMD10,UBB,CDC26,UBA52,PSMD14,PSMC4,PSMB5,PSMA3,NEK2,PSMB1,CDC20,PSMB7,CDC16,PSMD3,PSMB3,BUB3,PSMB6,PSMA2,PSMA5,PSMB10,PSMC5,PSMB11,PSMA4,ANAPC4,PTTG1,SEM1,PSMB9,CDC23,PSMB4,ANAPC15,ANAPC2,PSMD6,PSME2,UBE2D1,CCNA2,ANAPC11,PSMD4,RPS27A,PSMA1,PSMC3,PSMC1,CCNB1,PSMD12,ANAPC16,PSMA6,MAD2L1,PSMB2,PSMD1
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	7.01602486585655e-10	-21.0776541307126	74	49	0.0151749767729947	3229	10285	5718,5700,119504,5687,4085,5707,5690,9861,29882,5692,8697,25906,7321,5721,29945,5698,7979,5682,5702,5710,51529,890,6233,991,5689,5709,8881,5695,5704,5684,5693,4751,5705,122706,5699,5686,5685,5691,5694,5683,9184,983,5720,5716,5713,10213,7314,246184,7311	PSMD12,PSMC1,ANAPC16,PSMA6,MAD2L1,PSMD1,PSMB2,PSMD6,ANAPC2,PSMB4,CDC23,ANAPC15,UBE2D1,PSME2,ANAPC4,PSMB9,SEM1,PSMA1,PSMC3,PSMD4,ANAPC11,CCNA2,RPS27A,CDC20,PSMB1,PSMD3,CDC16,PSMB7,PSMC4,PSMA3,PSMB5,NEK2,PSMC5,PSMB11,PSMB10,PSMA5,PSMA4,PSMB3,PSMB6,PSMA2,BUB3,CDK1,PSME1,PSMD10,PSMD7,PSMD14,UBB,CDC26,UBA52
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	1.50009230236978e-09	-20.3177391958183	73	48	0.0148652833694642	3229	10285	5713,5720,983,5716,7314,7311,246184,10213,5704,5693,5684,5689,991,5695,5709,8881,5691,9184,5694,5683,5686,5699,5705,122706,5685,29945,7979,5698,8697,5692,25906,29882,9861,5721,7321,890,51529,5710,6233,5682,5702,5700,5718,119504,5687,4085,5707,5690	PSMD7,PSME1,CDK1,PSMD10,UBB,UBA52,CDC26,PSMD14,PSMC4,PSMB5,PSMA3,PSMB1,CDC20,PSMB7,PSMD3,CDC16,PSMB3,BUB3,PSMB6,PSMA2,PSMA5,PSMB10,PSMC5,PSMB11,PSMA4,ANAPC4,SEM1,PSMB9,CDC23,PSMB4,ANAPC15,ANAPC2,PSMD6,PSME2,UBE2D1,CCNA2,ANAPC11,PSMD4,RPS27A,PSMA1,PSMC3,PSMC1,PSMD12,ANAPC16,PSMA6,MAD2L1,PSMD1,PSMB2
R-HSA-69239	Synthesis of DNA	1.53067982667125e-09	-20.2975538690702	101	61	0.0188912976153608	3229	10285	5713,5716,5720,84296,7311,7314,5925,10213,54107,5684,5693,1027,5001,5704,5982,5709,5695,57804,5689,4175,5683,5694,5425,5691,6118,4173,5685,5705,122706,5699,5686,5698,51343,7979,5983,23594,5721,6119,5985,9861,5692,6233,4172,5558,5710,5984,890,5111,5702,5682,56655,5718,23649,5700,64785,84515,1026,5690,5707,5687,2237	PSMD7,PSMD10,PSME1,GINS4,UBA52,UBB,RB1,PSMD14,POLE3,PSMA3,PSMB5,CDKN1B,ORC5,PSMC4,RFC2,PSMD3,PSMB7,POLD4,PSMB1,MCM6,PSMA2,PSMB6,POLD2,PSMB3,RPA2,MCM4,PSMA4,PSMC5,PSMB11,PSMB10,PSMA5,PSMB9,FZR1,SEM1,RFC3,ORC6,PSME2,RPA3,RFC5,PSMD6,PSMB4,RPS27A,MCM3,PRIM2,PSMD4,RFC4,CCNA2,PCNA,PSMC3,PSMA1,POLE4,PSMD12,POLA2,PSMC1,GINS3,MCM8,CDKN1A,PSMB2,PSMD1,PSMA6,FEN1
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	1.58736894784566e-09	-20.2611879411075	71	47	0.0145555899659337	3229	10285	1026,4609,5700,5718,5690,5707,5687,5721,5692,9861,7979,5698,51343,4149,5702,5682,6233,1163,890,5710,5695,5709,5689,5693,5684,1019,5704,1027,5685,5686,902,5699,5705,5694,5683,5691,5716,5720,595,6500,1022,4331,5713,5925,10213,7311,7314	CDKN1A,MYC,PSMC1,PSMD12,PSMB2,PSMD1,PSMA6,PSME2,PSMB4,PSMD6,SEM1,PSMB9,FZR1,MAX,PSMC3,PSMA1,RPS27A,CKS1B,CCNA2,PSMD4,PSMB7,PSMD3,PSMB1,PSMB5,PSMA3,CDK4,PSMC4,CDKN1B,PSMA4,PSMA5,CCNH,PSMB10,PSMC5,PSMB6,PSMA2,PSMB3,PSMD10,PSME1,CCND1,SKP1,CDK7,MNAT1,PSMD7,RB1,PSMD14,UBA52,UBB
R-HSA-69206	G1/S Transition	1.58885021401774e-09	-20.260255218141	119	69	0.0213688448436048	3229	10285	6118,5691,4175,5683,5694,5705,5686,902,5699,5685,4173,1027,5704,5001,1019,5693,5684,5689,5709,5695,7314,5518,7311,10213,5925,54107,5713,4331,1022,6500,983,595,5720,5716,10000,5687,207,5690,5707,208,5516,8317,5718,891,5700,23649,4609,56655,1026,84515,4172,7029,5710,5558,1163,890,7298,6233,5682,5702,5111,4149,5698,7979,9861,5692,23594,5721,6119	RPA2,PSMB3,MCM6,PSMA2,PSMB6,PSMC5,PSMA5,CCNH,PSMB10,PSMA4,MCM4,CDKN1B,PSMC4,ORC5,CDK4,PSMB5,PSMA3,PSMB1,PSMD3,PSMB7,UBB,PPP2R1A,UBA52,PSMD14,RB1,POLE3,PSMD7,MNAT1,CDK7,SKP1,CDK1,CCND1,PSME1,PSMD10,AKT3,PSMA6,AKT1,PSMB2,PSMD1,AKT2,PPP2CB,CDC7,PSMD12,CCNB1,PSMC1,POLA2,MYC,POLE4,CDKN1A,MCM8,MCM3,TFDP2,PSMD4,PRIM2,CKS1B,CCNA2,TYMS,RPS27A,PSMA1,PSMC3,PCNA,MAX,PSMB9,SEM1,PSMD6,PSMB4,ORC6,PSME2,RPA3
R-HSA-5619084	ABC transporter disorders	1.66933640929126e-09	-20.2108396491919	69	46	0.0142458965624032	3229	10285	5716,3767,6441,5720,5713,10213,51009,6048,7311,7314,5695,5709,5689,10956,5684,5693,5704,27248,5685,5699,5686,122706,5705,5694,5683,5691,5721,5692,9861,6440,7979,5698,5702,5682,6233,11160,5710,653509,79139,10613,5700,1080,5718,5707,5690,5687	PSMD10,KCNJ11,SFTPD,PSME1,PSMD7,PSMD14,DERL2,RNF5,UBA52,UBB,PSMB7,PSMD3,PSMB1,OS9,PSMA3,PSMB5,PSMC4,ERLEC1,PSMA4,PSMB10,PSMA5,PSMB11,PSMC5,PSMB6,PSMA2,PSMB3,PSME2,PSMB4,PSMD6,SFTPC,SEM1,PSMB9,PSMC3,PSMA1,RPS27A,ERLIN2,PSMD4,SFTPA1,DERL1,ERLIN1,PSMC1,CFTR,PSMD12,PSMD1,PSMB2,PSMA6
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	1.89395389354814e-09	-20.0845991859064	61	42	0.0130071229482812	3229	10285	7157,5702,10213,5682,6233,7311,7314,5710,5716,5721,5692,5720,983,9861,7979,5698,5713,5685,5686,5699,5705,122706,22919,5683,5694,5707,5690,5687,3320,5691,5695,3326,5709,5689,63943,1026,5684,5693,5700,5704,891,5718	TP53,PSMC3,PSMD14,PSMA1,RPS27A,UBA52,UBB,PSMD4,PSMD10,PSME2,PSMB4,PSME1,CDK1,PSMD6,SEM1,PSMB9,PSMD7,PSMA4,PSMA5,PSMB10,PSMC5,PSMB11,MAPRE1,PSMA2,PSMB6,PSMD1,PSMB2,PSMA6,HSP90AA1,PSMB3,PSMB7,HSP90AB1,PSMD3,PSMB1,FKBPL,CDKN1A,PSMA3,PSMB5,PSMC1,PSMC4,CCNB1,PSMD12
R-HSA-1430728	Metabolism	3.55332976140242e-09	-19.4553807121112	2158	790	0.244657788789099	3229	10285	5687,6483,56548,5092,25915,79586,4953,5834,2820,6818,55454,55326,344,140801,1581,259230,23632,5702,84836,8904,7979,4722,28234,5692,874,255738,3972,54480,440387,5160,6133,6141,1727,50515,283927,2782,55331,7311,6124,6228,9583,53343,79077,1562,81894,7436,83930,515,7360,55090,2785,5906,51,5867,1120,1565,4534,443,5223,121278,50814,1645,389396,3613,84725,2632,129401,27306,1841,89874,59345,6175,646486,4502,6231,6218,1733,9861,55588,64180,56985,4729,5699,94103,55347,5705,7295,35,5805,7276,5322,3292,5684,514,119391,5837,5695,51763,5709,161247,1131,6794,6785,4712,10632,54331,6604,5713,6383,7357,4060,788,128486,9349,9442,5264,54981,2542,166929,6147,79873,222537,2791,113278,1387,6515,54996,124,64816,60496,7372,414149,79017,5710,3028,4946,5243,4597,83549,6138,1629,6234,8841,8833,10678,8898,3417,6193,9377,6837,55224,4698,5728,27284,1592,6303,55902,55349,10057,6240,55163,27089,2767,4259,6168,5500,84987,83401,51552,6154,388121,4489,4520,5716,9415,6130,5007,5471,5831,5718,9955,3921,9791,9412,8976,57546,7351,6157,1584,3620,23169,10560,9429,2949,6723,125,11041,79152,4706,3145,79993,5294,51121,1384,23568,3631,1962,10090,1376,6160,29956,6136,10975,3735,51070,7314,2952,25816,6205,10554,10588,3930,64834,55970,3043,5549,5720,11164,6209,4594,4800,51251,2879,6901,8702,100137049,79837,1635,3038,6217,8692,11019,2875,36,6128,516,6224,1349,6233,5501,857,1743,5868,2683,5236,9227,51495,1345,5260,4521,253782,83539,338328,160,51128,5686,5257,2790,513,7358,1545,3176,196743,25942,5019,10243,79644,5230,2581,9481,56910,9049,1352,4493,57122,2987,23479,1175,9435,10449,6307,51228,2197,6161,9439,2539,8503,9896,5476,43,6120,2131,2182,2052,23389,10728,4801,3030,3340,8574,5721,63874,6143,51204,641372,1785,22934,5730,346,2817,3636,10162,6535,83594,5578,113451,1559,50640,9217,51065,1728,6539,6652,3320,5290,6158,207,6844,373156,11010,10101,522,6484,9962,154807,5045,126410,2939,80219,10249,26289,4694,85465,55967,1586,6134,8604,275,6146,79153,8789,23600,26020,9370,6470,768213,3326,5296,10577,4947,3033,29967,116228,5507,166012,7385,3745,51686,80704,948,1737,2395,84890,6576,5901,2793,3418,55750,2167,1734,6191,94101,1312,55790,51003,23683,213,5465,79966,2686,126282,108,5683,79071,8228,51504,51094,2109,4697,23179,201562,10213,10478,51000,7923,3420,1577,23344,4713,51582,132,55748,6165,57678,1351,2531,2582,4258,784,2946,10423,2752,4695,2597,518,51477,80777,51300,3293,51660,9967,3939,5644,10484,11224,2326,4942,1327,91942,56848,6139,27430,51573,1375,11283,8884,375,11163,8801,2745,6206,7384,152926,2331,2033,79178,7376,80150,10295,22978,2098,10007,6208,3074,23576,2771,649,64428,4758,85414,9107,23564,66002,2328,1152,1735,9453,6181,38,6132,4144,117245,165679,2173,9200,50,2948,27349,1572,109,5693,90390,2950,8560,4952,9489,5567,9331,384,57407,6482,55863,10476,400569,316,64781,6385,79799,441024,5690,2350,11097,132789,4720,9630,84320,5516,549,5700,6229,6513,1646,5208,6176,29914,23636,5948,4141,51764,92483,7296,11285,2184,134147,4726,6309,10005,10434,4718,204,9060,771,5096,56623,1468,6391,285440,6170,5162,51727,4831,11165,15,9348,4190,5255,9391,57107,2203,2222,4716,2997,11185,6812,9446,693216,7298,1593,1457,5698,4728,120227,2729,9440,956,2644,122706,51170,4710,81034,2877,10762,25974,29116,131870,1460,390916,5518,6203,3290,2712,2788,6187,50486,539,6534,7263,6610,80772,6579,1633,1024,55711,2327,29079,401494,5538,1428,438,92579,7388,6207,159,23646,9524,653689,10955,6235,6390,4830,51141,58526,5691,51205,8534,23236,387787,506,2239,166785,6804,9957,2938,2171,114757,6616,1543,134429,4499,241,2947,31,22908,6155,26063,4860,4969,84246,55788,9807,10327,4736,5091,3767,90809,6159,1528,51302,55856,1173,6697,783,6152,231,29920,4711,1353,9016,2108,51084,114971,1589,54,280,137682,3949,5447,1800,1594,3945,1585,952,494143,5330,669,57515,2026,4501,29923,5468,3157,5295,51109,8402,3419,51241,8703,2739,9653,6204,5917,26035,114882,5707,84869,1537,4714,51167,81579,54658,51099,5682,5631,23521,29881,6566,3988,2941,27232,8394,6188,2787,291,4504,2023,8443,7371,8706,6129,644,51706,6201,3163,3039,10,10840,29801,5106,4507,693224,6538,2776,2876,55697,292,6122,2784,1558,3073,9536,79023,29078,80765,9521,23760,1036,9972,6667,9468,171546,1621,6770,79602,11261,498,5694,5685,9023,5704,6005,10768,5689,79626,85007,11145,2593,1340,4833,760,27249	PSMA6,ST3GAL2,CHST7,PCBD1,NDUFAF3,CHPF,ODC1,PYGB,GPD2,SULT1A3,CSGALNACT2,AGPAT5,APOC2,RPL10L,CYP7A1,SGMS1,CA14,PSMC3,ABHD14B,CPNE1,SEM1,NDUFS3,SLCO1B3,PSMB4,CBR3,PCSK9,LHB,CHPF2,CTRB2,PDHA1,RPL9,RPL18,CYB5R3,CHST11,NUDT7,GNB1,ACER3,UBA52,RPL4,RPS23,ENTPD4,NUDT9,DCTPP1,CYP2C18,SLC25A28,VLDLR,STARD3NL,ATP5PB,UGP2,MED9,GNG3,RAP1A,ACOX1,RAB4A,CHKB,CYP2D6,MTM1,ASPA,PGAM1,TPH2,NSDHL,AKR1C1,GLYATL3,IMPA2,PLEKHA8,GBE1,NUP35,HPGDS,DTYMK,SLC25A21,GNB4,RPLP0,FABP12,MT2A,RPS26,RPS17,DIO1,PSMD6,MED29,DPEP3,ADPRM,NDUFV2,PSMB10,ORMDL3,ABHD10,PSMC5,TXN,ACADS,PTS,TTR,PLA2G5,HSD17B1,PSMA3,ATP5F1E,GSTO2,PYGM,PSMB7,INPP5K,PSMD3,FITM1,CHRM3,STK11,ELOVL4,NDUFB6,ATP5MG,GNG2,SMARCD3,PSMD7,SDC2,UGCG,LUM,SLC25A20,FITM2,RPL23,MED27,PHYH,NMRK1,SLC37A4,SGMS2,RPL23A,NUDT18,HS3ST5,GNG11,SLC52A3,CREBBP,SLC2A3,MTARC2,ADH1A,CYP3A43,AASDHPPT,UMPS,ACBD7,GGCT,PSMD4,HSD17B10,OAZ1,ABCB1,MVD,UCK1,RPL15,DBT,RPS28,HDAC3,GMPS,B3GNT2,MTMR2,IDH1,RPS5,COX5A,MED22,ETNK2,NDUFA5,PTEN,SULT1B1,CYP26A1,SAT1,ACSS2,CHDH,ABCC5,RRM1,PNPO,UQCRQ,GNA11,MGST3,RPL37A,PPP1CB,COX14,ELOVL3,RAB14,RPL26,TNFAIP8L3,MT1A,MTF1,PSMD10,FADS2,RPL7A,OSBP,PPAT,PYCR1,PSMD12,HS3ST3A1,RPSA,PTDSS1,MED21,WASL,PDP2,UCP2,RPL27A,CYP11B1,IDO1,SLC35D1,SLC19A2,ABCG2,GSTM5,SRM,ADH1B,B4GAT1,FA2H,NDUFAB1,HMBS,ELOVL7,PIK3CG,RPL26L1,CRAT,ARL2BP,INPP4A,EHHADH,UST,CPT2,RPL31,CERS2,RPL12,UQCR11,KARS1,NOSIP,UBB,GSTT1,TNFAIP8,RPS11,AGPAT1,MTHFS,LBR,ELOVL1,GNG12,HBB,PRELP,PSME1,NUDT5,RPS15,MMUT,NFYA,NT5C3A,GPX4,TAFAZZIN,B4GALT4,PLA2G4B,PIP4K2C,DCTD,HAS3,RPS16,HYAL2,LIAS,GPT,ACADSB,RPL6,ATP5MC1,RPS20,COX7B,RPS27A,PPP1CC,CAV1,DLST,RAB5A,B4GALT1,PGM1,LRAT,HACD3,COX6C,PHKG1,NUDT1,CERS6,CHST9,GPIHBP1,AP2A1,SAR1B,PSMA5,PHKB,GNG10,ATP5F1D,UGDH,CYP1B1,HNMT,PAOX,SIN3A,OXCT1,GPHN,SRD5A3,PGK1,GALC,SLC25A27,STARD7,AIP,COX10,MT1E,NUP107,GUK1,ISCU,AP2S1,CHST2,ACAA2,MSMO1,GLTP,FAU,RPL32,MED23,G6PD,PIK3R3,FIG4,CTSA,ACHE,RPE,EXT1,ACSL4,EPHX1,MED13L,PTGES3,NFYB,HADHA,NDST1,AKR7A2,PSME2,ABHD4,RPL19,TACO1,ACOT6,DNM2,RPIA,PTGDS,APOC4,GPC1,INPPL1,LPCAT3,SLC6A8,NUDT12,PRKCA,AZIN2,CYP2C9,PNPLA8,VAPB,RPS27L,NQO1,SLC6A12,SORD,HSP90AA1,PIK3CA,RPL28,AKT1,VAMP2,GSTK1,GLIPR1,NUBP2,ATP5PF,ST3GAL4,SLC23A2,VKORC1L1,FURIN,CYP4F22,GSTA2,COQ10B,GLYAT,AK5,NDUFA1,SELENOI,NDUFA12,CYP17A1,RPL10,SLC25A12,AMT,RPL22,GDPD3,FBP2,AMACR,LRP10,ADIPOQ,SHMT1,MIR671,HSP90AB1,PIK3R2,NPC2,OAZ2,HADH,LRP12,COX20,PPP1R3C,CHST13,UQCRC2,KCNB1,OAZ3,SLC19A3,CD36,DLAT,FXN,ADO,SLC25A1,RAN,GNGT2,IDH2,AGK,FABP4,DIO2,RPS4X,ORMDL1,COMT,CSGALNACT1,MED31,PRKD3,ALB,PPARA,SCD5,GGT7,TNFAIP8L1,ADCY2,PSMA2,ELOVL6,PNPLA4,TRMT112,ADIPOR1,ETFB,NDUFA4,RGL1,HACD2,PSMD14,SLC25A17,SLC35B3,HSD17B8,IDH3B,CYP3A5,ESYT1,NDUFB7,AZIN1,ADK,CNDP2,RPL35A,GPAM,COX8A,KDSR,GALE,MGST2,CACNB3,GSTM2,CDIPT,GLUL,NDUFA2,GAPDH,ATP5MC3,ISYNA1,CYB5B,TIMMDC1,HSD17B3,MPC1,THRAP3,LDHA,PRSS1,SEC23A,RPL35,FMO1,OAT,COX4I1,NDUFAF2,SPHK2,RPL17,MAT2B,GDE1,CPT1B,CYP4F8,SLC5A6,ARF1,NUDT4,SUCLG2,GLRX,RPS12,UQCRC1,PPM1K,FMOD,EP300,THTPA,NR1H2,ASRGL1,BCKDK,NT5C2,ESD,GNPDA1,RPS14,HEXB,DDAH1,GNAI2,BMP1,CIAO3,NEU1,SLC45A3,MTMR6,DDAH2,CYP4F12,FMO3,CKB,DIO3,GGPS1,RPLP2,ACAT1,RPL8,MAT2A,PLAAT5,SPTSSB,FABP7,HACD1,ACO2,GSTM4,MCAT,CYP2F1,ADCY3,PSMB5,MED30,GSTP1,DEGS1,OCRL,PGS1,PRKACB,B4GALT6,ARG2,NMRAL1,ST3GAL1,TMEM126B,ATP5PD,MED11,AOX1,CERK,SDC4,UGT2A3,MTHFD2L,PSMB2,FOLR2,NUP42,GNPDA2,NDUFS2,GNA14,ACBD6,PPP2CB,AUH,PSMC1,RPS24,SLC2A1,AKR1C2,PFKFB2,RPLP1,UBIAD1,NUP62,RBP2,MARS1,GNG13,LDHAL6B,TXNRD1,B4GALT7,FAH,CMBL,NDUFS6,SC5D,ACOT8,LYPLA1,NDUFC2,AK2,PAPSS2,CA12,PCCB,INPP5E,SLC25A10,SDHC,CYP4V2,RPL39,PDHB,CMPK1,NME2,NUDT3,AANAT,NDST3,MDH1,PHKA1,CIAO1,PDSS2,FBP1,FDFT1,NDUFB10,GYS1,INMT,STXBP1,GSTO1,MIR631,TYMS,CYP27A1,CSNK2A1,PSMB9,NDUFS8,CYP2R1,GCLC,MED17,ENTPD3,GCHFR,PSMB11,HSD17B11,NDUFB4,SLC25A32,GPX2,NUP50,MMACHC,MYLIP,NUDT16,CSNK2B,NUDT19,PPP2R1A,RPS9,HSD11B1,GK2,GNG7,RPS2,G0S2,ATP5PO,SLC6A7,TST,SMPD2,CPTP,SLCO1A2,DCK,CDK8,FAR2,FMO2,MED4,HACD4,PPT1,CRYM,ASMT,G6PC3,UQCRH,RPS13,ADSS2,PLD3,TECR,GSTT2B,SERINC3,RPS29,SDHB,NME1,INSIG2,MID1IP1,PSMB3,ACP6,CHST1,PLCB1,LIPT2,ATP5F1B,GPC4,MMAA,STX1A,HS3ST1,GSTA1,FABP5,CYGB,SNAP25,CYP1A1,STARD4,MT1M,ALOX5AP,GSTM3,ACACA,SACM1L,RPL27,DECR2,PNP,OGN,MED10,LMBRD1,IP6K1,AKR1A1,RPL10A,PC,KCNJ11,PIP4P1,RPL29,CYB5A,CYP39A1,ACOT13,AP2M1,SPR,CACNB2,RPL24,AKR1B1,PYCR2,NDUFB5,COX11,SLC25A14,ETFA,CRYL1,PTPMT1,CYP21A2,ACP5,AMY2B,NDUFAF6,LDLR,POR,DPEP1,CYP27B1,LDHB,CYP11B2,CD38,CHAC2,PLCB2,BPGM,SERINC1,ENO2,MT1X,HILPDA,PPARG,HMGCS1,PIK3R1,RDH11,SLC25A11,IDH3A,COX16,B4GALT3,GLO1,HS2ST1,RPS10,RARS1,GLCE,OSBPL8,PSMD1,CBR4,CYC1,NDUFB8,CYB5R4,PLA2G12A,UGT1A1,ABHD5,PSMA1,PRPS1,RPL13A,NPC1L1,SLC16A1,LIPA,GSTA4,GNMT,PIP5K1A,RPS3,GNG5,SLC25A4,MT3,ENO1,GNPAT,UCK2,B3GALNT1,RPL7,BLVRA,CYB5R1,RPS7,HMOX2,HBA1,NAT2,ALDH1L1,ZDHHC8,PCK2,MTAP,MIR639,SLC6A11,GNAQ,GPX1,VAC14,SLC25A5,RPL3,GNB3,CYP2C8,HEXA,PTGES,NUP37,NDUFAF4,STARD5,EEF1E1,PITPNB,CDO1,NUP153,SP1,PCYT1B,SPTSSA,DBH,STAR,ADIPOR2,CHP1,ATP5F1A,PSMB6,PSMA4,CH25H,PSMC4,RHAG,AHCYL1,PSMB1,TNFAIP8L2,PHYKPL,PLAAT3,GAMT,COX6B1,NME4,CA2,MMADHC
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	3.59256158978733e-09	-19.4444003541314	68	45	0.0139362031588727	3229	10285	5684,5693,5704,5709,8881,5695,991,5689,5694,5683,5691,5685,122706,5705,5699,5686,5713,5716,5720,246184,7311,7314,10213,119504,5718,5700,5707,5690,5687,5698,7979,9232,29945,7321,5721,9861,29882,25906,8697,5692,6233,5710,51529,5702,5682	PSMA3,PSMB5,PSMC4,PSMD3,CDC16,PSMB7,CDC20,PSMB1,PSMB6,PSMA2,PSMB3,PSMA4,PSMB11,PSMC5,PSMB10,PSMA5,PSMD7,PSMD10,PSME1,CDC26,UBA52,UBB,PSMD14,ANAPC16,PSMD12,PSMC1,PSMD1,PSMB2,PSMA6,PSMB9,SEM1,PTTG1,ANAPC4,UBE2D1,PSME2,PSMD6,ANAPC2,ANAPC15,CDC23,PSMB4,RPS27A,PSMD4,ANAPC11,PSMC3,PSMA1
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	3.94891088492665e-09	-19.3498260213876	64	43	0.0133168163518117	3229	10285	5710,7314,51529,7311,246184,6233,5682,10213,5702,5713,29945,5698,51343,7979,29882,9861,5720,25906,5692,8697,7321,5716,5721,5691,5687,5690,5707,5694,5683,5705,5686,5699,5685,5718,5704,5700,5684,5693,119504,5689,5709,8881,5695	PSMD4,UBB,ANAPC11,UBA52,CDC26,RPS27A,PSMA1,PSMD14,PSMC3,PSMD7,ANAPC4,PSMB9,FZR1,SEM1,ANAPC2,PSMD6,PSME1,ANAPC15,PSMB4,CDC23,UBE2D1,PSMD10,PSME2,PSMB3,PSMA6,PSMB2,PSMD1,PSMB6,PSMA2,PSMC5,PSMA5,PSMB10,PSMA4,PSMD12,PSMC4,PSMC1,PSMA3,PSMB5,ANAPC16,PSMB1,PSMD3,CDC16,PSMB7
R-HSA-5678895	Defective CFTR causes cystic fibrosis	4.09341198137268e-09	-19.3138869893897	62	42	0.0130071229482812	3229	10285	7311,6233,5710,7314,11160,10213,5702,51009,6048,5682,5698,7979,5713,5721,5716,9861,5720,5692,5707,5690,5683,5694,5691,5687,5685,122706,5705,5686,5699,10613,5693,5684,5718,27248,5704,5700,1080,5709,5695,10956,79139,5689	UBA52,RPS27A,PSMD4,UBB,ERLIN2,PSMD14,PSMC3,DERL2,RNF5,PSMA1,PSMB9,SEM1,PSMD7,PSME2,PSMD10,PSMD6,PSME1,PSMB4,PSMD1,PSMB2,PSMA2,PSMB6,PSMB3,PSMA6,PSMA4,PSMB11,PSMC5,PSMA5,PSMB10,ERLIN1,PSMB5,PSMA3,PSMD12,ERLEC1,PSMC4,PSMC1,CFTR,PSMD3,PSMB7,OS9,DERL1,PSMB1
R-HSA-2408522	Selenoamino acid metabolism	4.20910102490626e-09	-19.28601674533	121	69	0.0213688448436048	3229	10285	6128,3921,6224,6217,6229,11185,6161,2197,6122,6165,6152,6130,6158,6147,6208,6181,4141,6193,6132,6138,6231,6234,6218,6191,6176,6175,6235,23521,9521,140801,6207,6233,6157,3176,6136,6141,6160,6133,6146,6188,6139,7296,6134,11224,51121,27232,6143,5917,9349,6209,4736,6159,6154,51065,6201,6204,6170,6124,6187,6155,6206,6228,6205,6168,3735,6203,9060,6129,7311	RPL6,RPSA,RPS20,RPS16,RPS24,INMT,RPL32,FAU,RPL3,RPL35A,RPL24,RPL7A,RPL28,RPL23A,RPS14,RPLP2,MARS1,RPS5,RPL8,RPL15,RPS26,RPS28,RPS17,RPS4X,RPLP1,RPLP0,RPS29,RPL13A,EEF1E1,RPL10L,RPS13,RPS27A,RPL27A,HNMT,RPL12,RPL18,RPL31,RPL9,RPL22,RPS3,RPL17,TXNRD1,RPL10,RPL35,RPL26L1,GNMT,RPL19,RARS1,RPL23,RPS15,RPL10A,RPL29,RPL26,RPS27L,RPS7,RPS10,RPL39,RPL4,RPS2,RPL27,RPS12,RPS23,RPS11,RPL37A,KARS1,RPS9,PAPSS2,RPL7,UBA52
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	4.20951217073783e-09	-19.2859190699	52	37	0.0114586559306287	3229	10285	5720,51686,5692,9861,5721,5716,1728,5713,7979,5698,5682,4947,10213,5702,5710,4946,5689,5695,5709,5704,5700,5718,5684,5693,5699,5686,122706,5705,5685,4953,5687,5691,51582,5690,5707,5683,5694	PSME1,OAZ3,PSMB4,PSMD6,PSME2,PSMD10,NQO1,PSMD7,SEM1,PSMB9,PSMA1,OAZ2,PSMD14,PSMC3,PSMD4,OAZ1,PSMB1,PSMB7,PSMD3,PSMC4,PSMC1,PSMD12,PSMA3,PSMB5,PSMB10,PSMA5,PSMB11,PSMC5,PSMA4,ODC1,PSMA6,PSMB3,AZIN1,PSMB2,PSMD1,PSMA2,PSMB6
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	4.42810178053524e-09	-19.2352948366968	81	51	0.0157943635800557	3229	10285	5705,122706,5699,5686,5685,5691,5683,5694,9184,991,5689,5709,8881,5695,5704,5684,5693,10213,7314,246184,7311,983,6500,5720,5716,5713,5687,4085,5690,5707,891,5718,5700,119504,5682,5702,5710,890,51529,6233,9861,29882,8697,5692,25906,5721,7321,29945,5698,51343,7979	PSMC5,PSMB11,PSMB10,PSMA5,PSMA4,PSMB3,PSMA2,PSMB6,BUB3,CDC20,PSMB1,PSMD3,CDC16,PSMB7,PSMC4,PSMA3,PSMB5,PSMD14,UBB,CDC26,UBA52,CDK1,SKP1,PSME1,PSMD10,PSMD7,PSMA6,MAD2L1,PSMB2,PSMD1,CCNB1,PSMD12,PSMC1,ANAPC16,PSMA1,PSMC3,PSMD4,CCNA2,ANAPC11,RPS27A,PSMD6,ANAPC2,CDC23,PSMB4,ANAPC15,PSME2,UBE2D1,ANAPC4,PSMB9,FZR1,SEM1
R-HSA-1236975	Antigen processing-Cross presentation	5.12739208131348e-09	-19.0886686732413	101	60	0.0185816042118303	3229	10285	3685,6233,5710,5702,5682,5698,929,7979,9554,4615,23480,3551,3693,7097,5721,9861,5692,5707,5690,6892,5687,811,114609,2209,2923,5718,5700,29927,7311,7099,8673,7314,4360,10213,7096,5713,9341,948,5716,5720,5683,5694,10952,55176,5691,5685,5705,122706,5699,5686,23643,567,5693,5684,10333,5704,8773,5709,5695,5689	ITGAV,RPS27A,PSMD4,PSMC3,PSMA1,PSMB9,CD14,SEM1,SEC22B,MYD88,SEC61G,IKBKB,ITGB5,TLR2,PSME2,PSMD6,PSMB4,PSMD1,PSMB2,TAPBP,PSMA6,CALR,TIRAP,FCGR1A,PDIA3,PSMD12,PSMC1,SEC61A1,UBA52,TLR4,VAMP8,UBB,MRC1,PSMD14,TLR1,PSMD7,VAMP3,CD36,PSMD10,PSME1,PSMA2,PSMB6,SEC61B,SEC61A2,PSMB3,PSMA4,PSMC5,PSMB11,PSMB10,PSMA5,LY96,B2M,PSMB5,PSMA3,TLR6,PSMC4,SNAP23,PSMD3,PSMB7,PSMB1
R-HSA-69306	DNA Replication	9.65047092259065e-09	-18.4562591225177	109	63	0.0195106844224218	3229	10285	6233,5710,5558,4172,5984,890,5111,5702,5682,5698,51343,7979,5983,23594,5721,6119,5985,9861,5692,5690,5707,5687,2237,8317,56655,5718,5700,23649,64785,84515,1026,7311,7314,10213,5925,51053,54107,5713,5716,5720,84296,5683,4175,5694,5425,5691,6118,4173,5685,5705,122706,5686,5699,5684,5693,1027,5001,5704,5982,5709,5695,57804,5689	RPS27A,PSMD4,PRIM2,MCM3,RFC4,CCNA2,PCNA,PSMC3,PSMA1,PSMB9,FZR1,SEM1,RFC3,ORC6,PSME2,RPA3,RFC5,PSMD6,PSMB4,PSMB2,PSMD1,PSMA6,FEN1,CDC7,POLE4,PSMD12,PSMC1,POLA2,GINS3,MCM8,CDKN1A,UBA52,UBB,PSMD14,RB1,GMNN,POLE3,PSMD7,PSMD10,PSME1,GINS4,PSMA2,MCM6,PSMB6,POLD2,PSMB3,RPA2,MCM4,PSMA4,PSMC5,PSMB11,PSMA5,PSMB10,PSMA3,PSMB5,CDKN1B,ORC5,PSMC4,RFC2,PSMD3,PSMB7,POLD4,PSMB1
R-HSA-5619115	Disorders of transmembrane transporters	1.08851734673049e-08	-18.3358642060245	76	48	0.0148652833694642	3229	10285	5689,10956,5695,5709,5704,27248,5684,5693,5699,5686,5705,122706,5685,5691,5694,5683,5720,5716,3767,6441,5713,553,6048,51009,10213,7314,7311,79139,653509,1080,5700,5718,10613,5687,5707,5690,5692,6440,213,9861,5721,7979,5698,5682,5702,11160,5710,6233	PSMB1,OS9,PSMB7,PSMD3,PSMC4,ERLEC1,PSMA3,PSMB5,PSMB10,PSMA5,PSMC5,PSMB11,PSMA4,PSMB3,PSMB6,PSMA2,PSME1,PSMD10,KCNJ11,SFTPD,PSMD7,AVPR1B,RNF5,DERL2,PSMD14,UBB,UBA52,DERL1,SFTPA1,CFTR,PSMC1,PSMD12,ERLIN1,PSMA6,PSMD1,PSMB2,PSMB4,SFTPC,ALB,PSMD6,PSME2,SEM1,PSMB9,PSMA1,PSMC3,ERLIN2,PSMD4,RPS27A
R-HSA-453276	Regulation of mitotic cell cycle	1.181688863969e-08	-18.2537360880718	87	53	0.0164137503871168	3229	10285	9232,29945,5698,51343,7979,9861,29882,25906,5692,8697,7321,5721,5710,890,51529,6233,5682,5702,5718,891,5700,119504,4085,5687,5690,5707,5713,6500,983,5720,5716,7314,7311,246184,10213,5704,4751,5684,5693,991,5689,5709,8881,5695,5691,5694,5683,9184,122706,5705,5686,5699,5685	PTTG1,ANAPC4,PSMB9,FZR1,SEM1,PSMD6,ANAPC2,ANAPC15,PSMB4,CDC23,UBE2D1,PSME2,PSMD4,CCNA2,ANAPC11,RPS27A,PSMA1,PSMC3,PSMD12,CCNB1,PSMC1,ANAPC16,MAD2L1,PSMA6,PSMB2,PSMD1,PSMD7,SKP1,CDK1,PSME1,PSMD10,UBB,UBA52,CDC26,PSMD14,PSMC4,NEK2,PSMA3,PSMB5,CDC20,PSMB1,PSMD3,CDC16,PSMB7,PSMB3,PSMB6,PSMA2,BUB3,PSMB11,PSMC5,PSMA5,PSMB10,PSMA4
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	1.181688863969e-08	-18.2537360880718	87	53	0.0164137503871168	3229	10285	5683,5694,9184,5691,5685,5705,122706,5686,5699,5684,5693,4751,5704,8881,5709,5695,991,5689,246184,7311,7314,10213,5713,5716,983,6500,5720,5690,5707,5687,4085,119504,891,5718,5700,6233,5710,890,51529,5702,5682,51343,5698,7979,9232,29945,7321,5721,9861,29882,5692,8697,25906	PSMA2,PSMB6,BUB3,PSMB3,PSMA4,PSMC5,PSMB11,PSMA5,PSMB10,PSMA3,PSMB5,NEK2,PSMC4,CDC16,PSMD3,PSMB7,CDC20,PSMB1,CDC26,UBA52,UBB,PSMD14,PSMD7,PSMD10,CDK1,SKP1,PSME1,PSMB2,PSMD1,PSMA6,MAD2L1,ANAPC16,CCNB1,PSMD12,PSMC1,RPS27A,PSMD4,CCNA2,ANAPC11,PSMC3,PSMA1,FZR1,PSMB9,SEM1,PTTG1,ANAPC4,UBE2D1,PSME2,PSMD6,ANAPC2,PSMB4,CDC23,ANAPC15
R-HSA-8868773	rRNA processing in the nucleus and cytosol	1.47565851096558e-08	-18.0315764056766	191	97	0.030040260142459	3229	10285	115939,6203,10199,10200,6187,6205,27341,51065,55781,51013,55813,6204,6209,9349,51121,6143,11102,6160,51602,5822,51504,54512,6136,55623,6157,6191,6175,51010,6231,6218,6181,55759,27042,6132,6130,6208,6152,6161,2197,6122,3921,56902,6168,7311,6129,51077,6124,6155,6206,6228,6154,54913,6201,6170,4736,1454,6159,6134,11224,27043,6146,84135,28987,11340,6188,6139,6141,6133,10885,140801,6207,6233,10436,6176,92856,81875,6235,23521,6138,10438,6234,1736,79050,6193,11103,55651,6158,55272,6147,6165,6217,114049,6229,79897,6128,6224,10171	TSR3,RPS9,MPHOSPH10,MPHOSPH6,RPS2,RPS11,RRP7A,RPS27L,RIOK2,EXOSC1,UTP6,RPS10,RPS15,RPL23,RPL26L1,RPL19,RPP14,RPL31,NOP58,PWP2,TRMT112,EXOSC4,RPL12,THUMPD1,RPL27A,RPS4X,RPLP0,EXOSC3,RPS26,RPS17,RPLP2,WDR12,UTP25,RPL8,RPL7A,RPS14,RPL24,RPL32,FAU,RPL3,RPSA,PNO1,RPL37A,UBA52,RPL7,FCF1,RPL4,RPL27,RPS12,RPS23,RPL26,RPP25,RPS7,RPL39,RPL10A,CSNK1E,RPL29,RPL10,RPL35,PELP1,RPL22,UTP15,NOB1,EXOSC8,RPS3,RPL17,RPL18,RPL9,WDR3,RPL10L,RPS13,RPS27A,EMG1,RPLP1,IMP4,ISG20L2,RPS29,RPL13A,RPL15,C1D,RPS28,DKC1,NOC4L,RPS5,KRR1,NHP2,RPL28,IMP3,RPL23A,RPL35A,RPS16,BUD23,RPS24,RPP21,RPL6,RPS20,RCL1
R-HSA-71291	Metabolism of amino acids and derivatives	1.7162918228643e-08	-17.8805146974009	361	163	0.0504800247754723	3229	10285	1735,1036,6231,6723,5698,6218,9861,6181,1733,1621,6132,4706,5721,38,6157,3620,1734,89874,6191,9521,1152,6175,5718,443,6122,121278,2197,6161,29920,11185,3921,6130,15,84890,4507,6208,6538,5831,6152,5713,51065,1728,6204,6539,6209,9349,6534,5720,5917,7263,85007,3735,6535,384,113451,6203,6187,2593,10213,6205,57407,57515,6160,5704,5693,5684,5689,6136,5709,5695,51121,2729,5683,5694,6143,122706,5705,5699,5685,6138,1629,6234,7979,4141,5692,6193,5710,6207,140801,6233,3028,4946,6176,2752,5682,5702,23521,6235,1743,10955,6229,11019,5700,6217,1428,2875,438,6128,36,6224,6147,6158,5687,5707,5690,5092,51582,6165,55748,4953,549,6154,6201,6170,5162,51686,80150,6159,1737,10295,4736,5716,196743,6168,7311,6129,9060,6206,6155,6124,1468,6228,152926,4947,2184,6133,6141,387787,6470,3176,27232,5691,275,11224,6134,4942,6146,5160,5686,6303,6139,7296,6188	DIO3,CDO1,RPS26,SRM,PSMB9,RPS17,PSMD6,RPLP2,DIO1,DBH,RPL8,NDUFAB1,PSME2,ACAT1,RPL27A,IDO1,DIO2,SLC25A21,RPS4X,EEF1E1,CKB,RPLP0,PSMD12,ASPA,RPL3,TPH2,FAU,RPL32,PYCR2,INMT,RPSA,RPL7A,AANAT,ADO,MTAP,RPS14,SLC6A11,PYCR1,RPL24,PSMD7,RPS27L,NQO1,RPS10,SLC6A12,RPS15,RPL23,SLC6A7,PSME1,RARS1,TST,PHYKPL,KARS1,SLC6A8,ARG2,AZIN2,RPS9,RPS2,GAMT,PSMD14,RPS11,NMRAL1,SERINC1,RPL31,PSMC4,PSMB5,PSMA3,PSMB1,RPL12,PSMD3,PSMB7,RPL26L1,GCLC,PSMA2,PSMB6,RPL19,PSMB11,PSMC5,PSMB10,PSMA4,RPL15,DBT,RPS28,SEM1,MARS1,PSMB4,RPS5,PSMD4,RPS13,RPL10L,RPS27A,HSD17B10,OAZ1,RPLP1,GLUL,PSMA1,PSMC3,RPL13A,RPS29,DLST,SERINC3,RPS24,LIAS,PSMC1,RPS16,CRYM,GPT,ASMT,RPL6,ACADSB,RPS20,RPL23A,RPL28,PSMA6,PSMD1,PSMB2,PCBD1,AZIN1,RPL35A,CNDP2,ODC1,AUH,RPL26,RPS7,RPL39,PDHB,OAZ3,ASRGL1,RPL29,DLAT,BCKDK,RPL10A,PSMD10,PAOX,RPL37A,UBA52,RPL7,PAPSS2,RPS12,RPL27,RPL4,SLC25A10,RPS23,PPM1K,OAZ2,FAH,RPL9,RPL18,LIPT2,SHMT1,HNMT,GNMT,PSMB3,AMT,RPL35,RPL10,OAT,RPL22,PDHA1,PSMA5,SAT1,RPL17,TXNRD1,RPS3
R-HSA-453279	Mitotic G1-G1/S phases	1.78642581770937e-08	-17.8404638701455	143	77	0.0238463920718489	3229	10285	4175,5683,5694,1874,5691,6118,4173,5685,5699,902,5686,5705,5693,5684,5704,1019,5001,1032,1027,5695,5709,5689,7311,5518,7314,54107,10213,5925,4331,5713,5716,595,5720,983,6500,1022,5928,5690,5707,10000,207,5687,1021,4605,8317,5516,1859,208,56655,4609,5700,23649,891,5718,84515,1026,6233,7298,1163,890,5710,5558,7029,4172,5111,5702,5682,1031,7979,5698,896,4149,5721,6119,23594,5692,9861	MCM6,PSMA2,PSMB6,E2F4,PSMB3,RPA2,MCM4,PSMA4,PSMB10,CCNH,PSMA5,PSMC5,PSMB5,PSMA3,PSMC4,CDK4,ORC5,CDKN2D,CDKN1B,PSMB7,PSMD3,PSMB1,UBA52,PPP2R1A,UBB,POLE3,PSMD14,RB1,MNAT1,PSMD7,PSMD10,CCND1,PSME1,CDK1,SKP1,CDK7,RBBP4,PSMB2,PSMD1,AKT3,AKT1,PSMA6,CDK6,MYBL2,CDC7,PPP2CB,DYRK1A,AKT2,POLE4,MYC,PSMC1,POLA2,CCNB1,PSMD12,MCM8,CDKN1A,RPS27A,TYMS,CKS1B,CCNA2,PSMD4,PRIM2,TFDP2,MCM3,PCNA,PSMC3,PSMA1,CDKN2C,SEM1,PSMB9,CCND3,MAX,PSME2,RPA3,ORC6,PSMB4,PSMD6
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	2.19067286238579e-08	-17.6364720042149	52	36	0.0111489625270982	3229	10285	5693,5684,5718,5700,1019,5704,5709,5695,5689,5683,5694,5690,5707,5691,5687,5685,5705,122706,5686,5699,5698,7979,5713,5716,5721,9861,5692,595,5720,7311,6233,7314,5710,5702,10213,5682	PSMB5,PSMA3,PSMD12,PSMC1,CDK4,PSMC4,PSMD3,PSMB7,PSMB1,PSMA2,PSMB6,PSMB2,PSMD1,PSMB3,PSMA6,PSMA4,PSMC5,PSMB11,PSMA5,PSMB10,PSMB9,SEM1,PSMD7,PSMD10,PSME2,PSMD6,PSMB4,CCND1,PSME1,UBA52,RPS27A,UBB,PSMD4,PSMC3,PSMD14,PSMA1
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	2.19067286238579e-08	-17.6364720042149	52	36	0.0111489625270982	3229	10285	5685,5705,122706,5686,5699,5683,5694,5707,5690,5691,5687,5709,5695,5689,5684,5693,5718,5700,1019,5704,10213,5702,5682,7311,6233,7314,5710,5721,5716,9861,5692,595,5720,5698,7979,5713	PSMA4,PSMC5,PSMB11,PSMA5,PSMB10,PSMA2,PSMB6,PSMD1,PSMB2,PSMB3,PSMA6,PSMD3,PSMB7,PSMB1,PSMA3,PSMB5,PSMD12,PSMC1,CDK4,PSMC4,PSMD14,PSMC3,PSMA1,UBA52,RPS27A,UBB,PSMD4,PSME2,PSMD10,PSMD6,PSMB4,CCND1,PSME1,PSMB9,SEM1,PSMD7
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	2.4419696365339e-08	-17.527875802193	73	46	0.0142458965624032	3229	10285	5720,5716,5713,10213,7314,246184,7311,991,5689,8881,5709,5695,5704,5693,5684,122706,5705,5686,5699,5685,5691,5694,5683,9861,29882,25906,8697,5692,7321,5721,9232,29945,51343,5698,7979,5682,5702,5710,51529,6233,5718,5700,119504,5687,5707,5690	PSME1,PSMD10,PSMD7,PSMD14,UBB,CDC26,UBA52,CDC20,PSMB1,CDC16,PSMD3,PSMB7,PSMC4,PSMB5,PSMA3,PSMB11,PSMC5,PSMA5,PSMB10,PSMA4,PSMB3,PSMB6,PSMA2,PSMD6,ANAPC2,ANAPC15,CDC23,PSMB4,UBE2D1,PSME2,PTTG1,ANAPC4,FZR1,PSMB9,SEM1,PSMA1,PSMC3,PSMD4,ANAPC11,RPS27A,PSMD12,PSMC1,ANAPC16,PSMA6,PSMD1,PSMB2
R-HSA-69242	S Phase	2.95613642374918e-08	-17.3367975904601	130	71	0.0219882316506658	3229	10285	595,5720,84296,1022,6500,5716,5713,4331,5885,54107,10213,5925,7314,7311,5689,57804,5695,5982,5709,5001,5704,1019,1027,5684,5693,5686,902,5699,5705,122706,5685,4173,5691,6118,5425,5694,4175,5683,5692,9861,5985,6119,5721,23594,5983,4149,7979,5698,51343,5682,5111,5702,5984,1163,890,5710,4172,5558,6233,1026,84515,64785,5700,23649,5718,4609,56655,2237,5687,5707,5690	CCND1,PSME1,GINS4,CDK7,SKP1,PSMD10,PSMD7,MNAT1,RAD21,POLE3,PSMD14,RB1,UBB,UBA52,PSMB1,POLD4,PSMB7,RFC2,PSMD3,ORC5,PSMC4,CDK4,CDKN1B,PSMA3,PSMB5,PSMA5,CCNH,PSMB10,PSMC5,PSMB11,PSMA4,MCM4,PSMB3,RPA2,POLD2,PSMB6,MCM6,PSMA2,PSMB4,PSMD6,RFC5,RPA3,PSME2,ORC6,RFC3,MAX,SEM1,PSMB9,FZR1,PSMA1,PCNA,PSMC3,RFC4,CKS1B,CCNA2,PSMD4,MCM3,PRIM2,RPS27A,CDKN1A,MCM8,GINS3,PSMC1,POLA2,PSMD12,MYC,POLE4,FEN1,PSMA6,PSMD1,PSMB2
R-HSA-72312	rRNA processing	3.44585800221121e-08	-17.1835078132507	201	100	0.0309693403530505	3229	10285	6218,51010,6231,6132,6181,55759,27042,6157,55623,6175,6191,6161,2197,6122,3921,56902,6208,6130,6152,29960,6204,55813,27341,51065,55781,51013,6209,9349,6203,10199,115939,6205,10200,6187,51602,6160,51504,6136,54512,5822,6143,51121,11102,10438,6234,1736,6138,11103,6193,55651,79050,3028,6233,140801,6207,81875,6235,23521,6176,10436,92856,79897,114049,6217,6229,6224,10171,6128,6158,55272,6147,6165,6170,6154,54913,6201,4736,1454,6159,6129,7311,51077,6168,6228,6124,6155,51106,6206,10885,6141,6133,11224,6134,28987,11340,6188,6139,27043,6146,84135	RPS17,EXOSC3,RPS26,RPL8,RPLP2,WDR12,UTP25,RPL27A,THUMPD1,RPLP0,RPS4X,RPL32,FAU,RPL3,RPSA,PNO1,RPS14,RPL7A,RPL24,MRM2,RPS10,UTP6,RRP7A,RPS27L,RIOK2,EXOSC1,RPS15,RPL23,RPS9,MPHOSPH10,TSR3,RPS11,MPHOSPH6,RPS2,NOP58,RPL31,TRMT112,RPL12,EXOSC4,PWP2,RPL19,RPL26L1,RPP14,C1D,RPS28,DKC1,RPL15,KRR1,RPS5,NHP2,NOC4L,HSD17B10,RPS27A,RPL10L,RPS13,ISG20L2,RPS29,RPL13A,RPLP1,EMG1,IMP4,RPP21,BUD23,RPS16,RPS24,RPS20,RCL1,RPL6,RPL28,IMP3,RPL23A,RPL35A,RPL39,RPL26,RPP25,RPS7,RPL10A,CSNK1E,RPL29,RPL7,UBA52,FCF1,RPL37A,RPS23,RPL4,RPL27,TFB1M,RPS12,WDR3,RPL18,RPL9,RPL35,RPL10,NOB1,EXOSC8,RPS3,RPL17,PELP1,RPL22,UTP15
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	3.85234972205391e-08	-17.071997464404	179	91	0.0281820997212759	3229	10285	11224,6134,6146,84135,27043,6139,6188,28987,11340,6141,6133,10885,6168,7311,6129,51077,6155,6206,6124,6228,54913,6154,6201,6170,6159,1454,4736,6147,55272,6158,6165,6229,6217,79897,6128,10171,6224,6207,140801,6233,92856,10436,6176,6235,23521,81875,6138,10438,6234,79050,11103,6193,51121,6143,11102,6160,51602,5822,54512,6136,10199,6203,6187,10200,6205,55781,51013,27341,51065,55813,6204,6209,9349,6130,6208,6152,6122,6161,2197,56902,3921,6157,6191,6175,51010,6231,6218,27042,6181,55759,6132	RPL35,RPL10,RPL22,UTP15,PELP1,RPL17,RPS3,NOB1,EXOSC8,RPL18,RPL9,WDR3,RPL37A,UBA52,RPL7,FCF1,RPL27,RPS12,RPL4,RPS23,RPP25,RPL26,RPS7,RPL39,RPL29,CSNK1E,RPL10A,RPL23A,IMP3,RPL28,RPL35A,RPS24,RPS16,RPP21,RPL6,RCL1,RPS20,RPS13,RPL10L,RPS27A,IMP4,EMG1,RPLP1,RPS29,RPL13A,ISG20L2,RPL15,C1D,RPS28,NOC4L,KRR1,RPS5,RPL26L1,RPL19,RPP14,RPL31,NOP58,PWP2,EXOSC4,RPL12,MPHOSPH10,RPS9,RPS2,MPHOSPH6,RPS11,RIOK2,EXOSC1,RRP7A,RPS27L,UTP6,RPS10,RPS15,RPL23,RPL7A,RPS14,RPL24,RPL3,RPL32,FAU,PNO1,RPSA,RPL27A,RPS4X,RPLP0,EXOSC3,RPS26,RPS17,UTP25,RPLP2,WDR12,RPL8
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	3.93323137297988e-08	-17.0512194236086	61	40	0.0123877361412202	3229	10285	5718,1027,5700,5704,1019,5693,5684,1026,5689,5709,5695,5691,5687,5694,5683,5707,5690,5705,5699,5686,5685,5713,5698,7979,9861,6500,5692,595,5720,5716,5721,7314,5710,1163,890,7311,6233,5682,10213,5702	PSMD12,CDKN1B,PSMC1,PSMC4,CDK4,PSMB5,PSMA3,CDKN1A,PSMB1,PSMD3,PSMB7,PSMB3,PSMA6,PSMB6,PSMA2,PSMD1,PSMB2,PSMC5,PSMB10,PSMA5,PSMA4,PSMD7,PSMB9,SEM1,PSMD6,SKP1,PSMB4,CCND1,PSME1,PSMD10,PSME2,UBB,PSMD4,CKS1B,CCNA2,UBA52,RPS27A,PSMA1,PSMD14,PSMC3
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	4.40185354739201e-08	-16.9386550309626	57	38	0.0117683493341592	3229	10285	5702,10213,5682,7311,6233,3312,5710,7314,5716,5721,9861,5720,5692,5698,7979,5713,5685,3184,122706,5705,5686,5699,5707,5690,5683,5694,5691,3315,26986,5687,5709,5695,5689,5684,5693,5718,5704,5700	PSMC3,PSMD14,PSMA1,UBA52,RPS27A,HSPA8,PSMD4,UBB,PSMD10,PSME2,PSMD6,PSME1,PSMB4,PSMB9,SEM1,PSMD7,PSMA4,HNRNPD,PSMB11,PSMC5,PSMA5,PSMB10,PSMD1,PSMB2,PSMA2,PSMB6,PSMB3,HSPB1,PABPC1,PSMA6,PSMD3,PSMB7,PSMB1,PSMA3,PSMB5,PSMD12,PSMC4,PSMC1
R-HSA-69300	Removal of licensing factors from origins	4.4987277505321e-08	-16.9168861092535	74	46	0.0142458965624032	3229	10285	5690,5707,5687,84515,1026,5700,5718,5702,5682,6233,890,5710,4172,5721,23594,5692,9861,7979,51343,5698,5685,4173,5699,5686,5705,122706,4175,5683,5694,5691,5695,5709,5689,5693,5684,5001,5704,1027,51053,10213,5925,7311,7314,5716,5720,5713	PSMB2,PSMD1,PSMA6,MCM8,CDKN1A,PSMC1,PSMD12,PSMC3,PSMA1,RPS27A,CCNA2,PSMD4,MCM3,PSME2,ORC6,PSMB4,PSMD6,SEM1,FZR1,PSMB9,PSMA4,MCM4,PSMB10,PSMA5,PSMC5,PSMB11,MCM6,PSMA2,PSMB6,PSMB3,PSMB7,PSMD3,PSMB1,PSMB5,PSMA3,ORC5,PSMC4,CDKN1B,GMNN,PSMD14,RB1,UBA52,UBB,PSMD10,PSME1,PSMD7
R-HSA-180534	Vpu mediated degradation of CD4	4.76894186403372e-08	-16.8585562950998	53	36	0.0111489625270982	3229	10285	5695,5709,5689,920,5693,5684,5700,5704,5718,5685,5699,5686,5705,122706,5694,5683,5707,5690,5687,5691,5716,5721,5692,5720,9861,6500,7979,5698,5713,5702,10213,5682,6233,7311,7314,5710	PSMB7,PSMD3,PSMB1,CD4,PSMB5,PSMA3,PSMC1,PSMC4,PSMD12,PSMA4,PSMB10,PSMA5,PSMC5,PSMB11,PSMB6,PSMA2,PSMD1,PSMB2,PSMA6,PSMB3,PSMD10,PSME2,PSMB4,PSME1,PSMD6,SKP1,SEM1,PSMB9,PSMD7,PSMC3,PSMD14,PSMA1,RPS27A,UBA52,UBB,PSMD4
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	4.76894186403372e-08	-16.8585562950998	53	36	0.0111489625270982	3229	10285	5691,5687,5690,5707,5683,5694,122706,5705,5686,5699,5685,5718,5704,64326,5700,5693,5684,5689,5709,5695,5710,7314,7311,6233,5682,10213,5702,7157,5713,5698,7979,9861,5720,5692,5721,5716	PSMB3,PSMA6,PSMB2,PSMD1,PSMA2,PSMB6,PSMB11,PSMC5,PSMA5,PSMB10,PSMA4,PSMD12,PSMC4,COP1,PSMC1,PSMB5,PSMA3,PSMB1,PSMD3,PSMB7,PSMD4,UBB,UBA52,RPS27A,PSMA1,PSMD14,PSMC3,TP53,PSMD7,PSMB9,SEM1,PSMD6,PSME1,PSMB4,PSME2,PSMD10
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	4.89115847113972e-08	-16.8332515623599	51	35	0.0108392691235677	3229	10285	5709,5695,5689,5693,5684,5718,5704,5700,5685,122706,5705,5699,5686,5707,5690,5694,5683,5691,5687,5721,5716,9861,5062,5720,5692,5698,7979,5713,10213,5702,5682,7311,6233,5710,7314	PSMD3,PSMB7,PSMB1,PSMB5,PSMA3,PSMD12,PSMC4,PSMC1,PSMA4,PSMB11,PSMC5,PSMB10,PSMA5,PSMD1,PSMB2,PSMB6,PSMA2,PSMB3,PSMA6,PSME2,PSMD10,PSMD6,PAK2,PSME1,PSMB4,PSMB9,SEM1,PSMD7,PSMD14,PSMC3,PSMA1,UBA52,RPS27A,PSMD4,UBB
R-HSA-69052	Switching of origins to a post-replicative state	4.97217712981131e-08	-16.8168229454736	72	45	0.0139362031588727	3229	10285	5713,5716,5720,7311,7314,5925,10213,5693,5684,5001,5704,1027,5695,5709,5689,5683,5694,4175,5691,4173,5685,5686,5699,5705,122706,7979,51343,5698,5721,23594,5692,9861,6233,890,5710,4172,5702,5682,5700,5718,84515,1026,5690,5707,5687	PSMD7,PSMD10,PSME1,UBA52,UBB,RB1,PSMD14,PSMB5,PSMA3,ORC5,PSMC4,CDKN1B,PSMB7,PSMD3,PSMB1,PSMA2,PSMB6,MCM6,PSMB3,MCM4,PSMA4,PSMA5,PSMB10,PSMC5,PSMB11,SEM1,FZR1,PSMB9,PSME2,ORC6,PSMB4,PSMD6,RPS27A,CCNA2,PSMD4,MCM3,PSMC3,PSMA1,PSMC1,PSMD12,MCM8,CDKN1A,PSMB2,PSMD1,PSMA6
R-HSA-68949	Orc1 removal from chromatin	4.97217712981131e-08	-16.8168229454736	72	45	0.0139362031588727	3229	10285	84515,1026,5700,5718,5707,5690,5687,5721,23594,5692,9861,7979,5698,51343,5702,5682,6233,890,5710,4172,5695,5709,5689,5684,5693,5001,5704,1027,5685,4173,5686,5699,5705,122706,5694,4175,5683,5691,5716,5720,5713,10213,5925,7311,7314	MCM8,CDKN1A,PSMC1,PSMD12,PSMD1,PSMB2,PSMA6,PSME2,ORC6,PSMB4,PSMD6,SEM1,PSMB9,FZR1,PSMC3,PSMA1,RPS27A,CCNA2,PSMD4,MCM3,PSMB7,PSMD3,PSMB1,PSMA3,PSMB5,ORC5,PSMC4,CDKN1B,PSMA4,MCM4,PSMA5,PSMB10,PSMC5,PSMB11,PSMB6,MCM6,PSMA2,PSMB3,PSMD10,PSME1,PSMD7,PSMD14,RB1,UBA52,UBB
R-HSA-5687128	MAPK6/MAPK4 signaling	6.03696527430238e-08	-16.6227792962993	90	53	0.0164137503871168	3229	10285	122706,3725,5705,5699,5686,5685,5691,5683,5694,5689,10435,5709,5695,5704,5684,5693,998,10213,57690,7314,10642,7311,5567,983,5720,5896,26523,5716,5713,4343,3315,5687,7514,5707,5690,5718,5596,5700,4609,989,5682,5702,5710,10602,6233,8550,9861,5062,5692,5721,896,5698,7979	PSMB11,JUN,PSMC5,PSMB10,PSMA5,PSMA4,PSMB3,PSMA2,PSMB6,PSMB1,CDC42EP2,PSMD3,PSMB7,PSMC4,PSMA3,PSMB5,CDC42,PSMD14,TNRC6C,UBB,IGF2BP1,UBA52,PRKACB,CDK1,PSME1,RAG1,AGO1,PSMD10,PSMD7,MOV10,HSPB1,PSMA6,XPO1,PSMD1,PSMB2,PSMD12,MAPK4,PSMC1,MYC,SEPTIN7,PSMA1,PSMC3,PSMD4,CDC42EP3,RPS27A,MAPKAPK5,PSMD6,PAK2,PSMB4,PSME2,CCND3,PSMB9,SEM1
R-HSA-2871837	FCERI mediated NF-kB activation	6.48078771569746e-08	-16.5518386799117	79	48	0.0148652833694642	3229	10285	7979,5698,5721,7321,3551,5692,7189,9861,6233,5710,5702,5682,5700,7334,5718,8915,23118,5707,5690,5687,7335,4792,5713,5716,5720,6500,7311,7314,10235,5588,10213,10454,5684,5693,5704,5695,5709,5689,5683,5694,23291,5691,5685,4790,5686,5699,5705,122706	SEM1,PSMB9,PSME2,UBE2D1,IKBKB,PSMB4,TRAF6,PSMD6,RPS27A,PSMD4,PSMC3,PSMA1,PSMC1,UBE2N,PSMD12,BCL10,TAB2,PSMD1,PSMB2,PSMA6,UBE2V1,NFKBIA,PSMD7,PSMD10,PSME1,SKP1,UBA52,UBB,RASGRP2,PRKCQ,PSMD14,TAB1,PSMA3,PSMB5,PSMC4,PSMB7,PSMD3,PSMB1,PSMA2,PSMB6,FBXW11,PSMB3,PSMA4,NFKB1,PSMA5,PSMB10,PSMC5,PSMB11
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	8.32720723941448e-08	-16.301152609364	60	39	0.0120780427376897	3229	10285	5685,5705,122706,5699,5686,5694,5683,23291,5707,5690,5691,5687,5709,9020,5695,5689,5693,5684,5718,5700,5704,5702,10213,5682,7311,6233,7314,5710,9040,5716,5721,9039,9861,6500,5692,5720,5698,7979,5713	PSMA4,PSMC5,PSMB11,PSMB10,PSMA5,PSMB6,PSMA2,FBXW11,PSMD1,PSMB2,PSMB3,PSMA6,PSMD3,MAP3K14,PSMB7,PSMB1,PSMB5,PSMA3,PSMD12,PSMC1,PSMC4,PSMC3,PSMD14,PSMA1,UBA52,RPS27A,UBB,PSMD4,UBE2M,PSMD10,PSME2,UBA3,PSMD6,SKP1,PSMB4,PSME1,PSMB9,SEM1,PSMD7
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	8.91100200724729e-08	-16.2333940500668	58	38	0.0117683493341592	3229	10285	5691,5687,5694,5683,5707,5690,5705,122706,5699,5686,5685,27248,5718,5700,5704,5693,5684,10956,5689,5709,5695,7314,84447,5710,7311,6233,5682,51009,10213,5702,5713,5698,7979,9861,5692,5720,5716,5721	PSMB3,PSMA6,PSMB6,PSMA2,PSMD1,PSMB2,PSMC5,PSMB11,PSMB10,PSMA5,PSMA4,ERLEC1,PSMD12,PSMC1,PSMC4,PSMB5,PSMA3,OS9,PSMB1,PSMD3,PSMB7,UBB,SYVN1,PSMD4,UBA52,RPS27A,PSMA1,DERL2,PSMD14,PSMC3,PSMD7,PSMB9,SEM1,PSMD6,PSMB4,PSME1,PSMD10,PSME2
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	9.47149810270344e-08	-16.1723936546826	56	37	0.0114586559306287	3229	10285	5682,5702,10213,5710,7314,6233,7311,5720,5692,9861,6500,5716,5721,5713,7979,51343,5698,5699,5686,122706,5705,5685,5687,5691,5690,5707,5683,5694,5689,991,5695,5709,5704,5700,5718,5693,5684	PSMA1,PSMC3,PSMD14,PSMD4,UBB,RPS27A,UBA52,PSME1,PSMB4,PSMD6,SKP1,PSMD10,PSME2,PSMD7,SEM1,FZR1,PSMB9,PSMB10,PSMA5,PSMB11,PSMC5,PSMA4,PSMA6,PSMB3,PSMB2,PSMD1,PSMA2,PSMB6,PSMB1,CDC20,PSMB7,PSMD3,PSMC4,PSMC1,PSMD12,PSMB5,PSMA3
R-HSA-4641257	Degradation of AXIN	9.47149810270344e-08	-16.1723936546826	56	37	0.0114586559306287	3229	10285	5685,122706,5705,5699,5686,5690,5707,5683,5694,8658,5691,5687,5709,5695,5689,5684,5693,5718,5704,5700,5702,10213,5682,7311,6233,81847,5710,7314,5716,5721,9861,5720,5692,5698,7979,5713,80351	PSMA4,PSMB11,PSMC5,PSMB10,PSMA5,PSMB2,PSMD1,PSMA2,PSMB6,TNKS,PSMB3,PSMA6,PSMD3,PSMB7,PSMB1,PSMA3,PSMB5,PSMD12,PSMC4,PSMC1,PSMC3,PSMD14,PSMA1,UBA52,RPS27A,RNF146,PSMD4,UBB,PSMD10,PSME2,PSMD6,PSME1,PSMB4,PSMB9,SEM1,PSMD7,TNKS2
R-HSA-69541	Stabilization of p53	9.47149810270344e-08	-16.1723936546826	56	37	0.0114586559306287	3229	10285	5691,5687,5707,5690,5683,5694,122706,5705,5699,5686,5685,5718,5704,5700,64326,5693,5684,4193,5689,5709,5695,5710,7314,7311,6233,5682,5702,10213,7157,5713,5698,7979,9861,5720,5692,5721,5716	PSMB3,PSMA6,PSMD1,PSMB2,PSMA2,PSMB6,PSMB11,PSMC5,PSMB10,PSMA5,PSMA4,PSMD12,PSMC4,PSMC1,COP1,PSMB5,PSMA3,MDM2,PSMB1,PSMD3,PSMB7,PSMD4,UBB,UBA52,RPS27A,PSMA1,PSMC3,PSMD14,TP53,PSMD7,PSMB9,SEM1,PSMD6,PSME1,PSMB4,PSME2,PSMD10
R-HSA-69563	p53-Dependent G1 DNA Damage Response	1.35016286209096e-07	-15.8178704271983	65	41	0.0126974295447507	3229	10285	7979,5698,5713,5721,5716,5720,5692,9861,6233,7311,890,5710,7314,57060,10213,5702,7157,5682,5693,5684,4193,5704,64326,5700,1027,5718,5695,5709,5689,1026,5690,5707,5683,5694,5687,5691,5685,5699,5686,122706,5705	SEM1,PSMB9,PSMD7,PSME2,PSMD10,PSME1,PSMB4,PSMD6,RPS27A,UBA52,CCNA2,PSMD4,UBB,PCBP4,PSMD14,PSMC3,TP53,PSMA1,PSMB5,PSMA3,MDM2,PSMC4,COP1,PSMC1,CDKN1B,PSMD12,PSMB7,PSMD3,PSMB1,CDKN1A,PSMB2,PSMD1,PSMA2,PSMB6,PSMA6,PSMB3,PSMA4,PSMB10,PSMA5,PSMB11,PSMC5
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	1.35016286209096e-07	-15.8178704271983	65	41	0.0126974295447507	3229	10285	5716,5721,9861,5720,5692,5698,7979,5713,5702,10213,7157,5682,7311,6233,5710,57060,7314,890,5709,5695,1026,5689,4193,5684,5693,1027,5718,5704,64326,5700,5685,122706,5705,5686,5699,5707,5690,5683,5694,5691,5687	PSMD10,PSME2,PSMD6,PSME1,PSMB4,PSMB9,SEM1,PSMD7,PSMC3,PSMD14,TP53,PSMA1,UBA52,RPS27A,PSMD4,PCBP4,UBB,CCNA2,PSMD3,PSMB7,CDKN1A,PSMB1,MDM2,PSMA3,PSMB5,CDKN1B,PSMD12,PSMC4,COP1,PSMC1,PSMA4,PSMB11,PSMC5,PSMA5,PSMB10,PSMD1,PSMB2,PSMA2,PSMB6,PSMB3,PSMA6
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	1.61165280935979e-07	-15.6408354088803	61	39	0.0120780427376897	3229	10285	5713,7979,5698,5720,5692,9861,6500,9039,5716,5721,9040,5710,7314,6233,7311,5682,10213,5702,5704,5700,5718,5693,5684,5689,9020,5695,5709,5687,5691,5707,5690,23291,5683,5694,5686,5699,122706,5705,5685	PSMD7,SEM1,PSMB9,PSME1,PSMB4,PSMD6,SKP1,UBA3,PSMD10,PSME2,UBE2M,PSMD4,UBB,RPS27A,UBA52,PSMA1,PSMD14,PSMC3,PSMC4,PSMC1,PSMD12,PSMB5,PSMA3,PSMB1,MAP3K14,PSMB7,PSMD3,PSMA6,PSMB3,PSMD1,PSMB2,FBXW11,PSMA2,PSMB6,PSMA5,PSMB10,PSMB11,PSMC5,PSMA4
R-HSA-4641258	Degradation of DVL	1.74790286439661e-07	-15.5596789448362	59	38	0.0117683493341592	3229	10285	5700,8452,5704,5718,5693,5684,5689,1856,5695,5709,5687,5691,5683,5694,5707,5690,5686,5699,5705,122706,5685,5713,7979,5698,5692,5720,9861,5716,5721,23072,7314,5710,6233,7311,5682,59349,5702,10213	PSMC1,CUL3,PSMC4,PSMD12,PSMB5,PSMA3,PSMB1,DVL2,PSMB7,PSMD3,PSMA6,PSMB3,PSMA2,PSMB6,PSMD1,PSMB2,PSMA5,PSMB10,PSMC5,PSMB11,PSMA4,PSMD7,SEM1,PSMB9,PSMB4,PSME1,PSMD6,PSMD10,PSME2,HECW1,UBB,PSMD4,RPS27A,UBA52,PSMA1,KLHL12,PSMC3,PSMD14
R-HSA-180585	Vif-mediated degradation of APOBEC3G	2.02021342251382e-07	-15.4148924904165	55	36	0.0111489625270982	3229	10285	5683,5694,5690,5707,5687,5691,5685,5699,5686,5705,122706,5684,5693,5700,5704,5718,5695,5709,60489,5689,6233,7311,7314,5710,5702,10213,6921,5682,7979,5698,5713,5716,5721,5692,5720,9861	PSMA2,PSMB6,PSMB2,PSMD1,PSMA6,PSMB3,PSMA4,PSMB10,PSMA5,PSMC5,PSMB11,PSMA3,PSMB5,PSMC1,PSMC4,PSMD12,PSMB7,PSMD3,APOBEC3G,PSMB1,RPS27A,UBA52,UBB,PSMD4,PSMC3,PSMD14,ELOC,PSMA1,SEM1,PSMB9,PSMD7,PSMD10,PSME2,PSMB4,PSME1,PSMD6
R-HSA-1169091	Activation of NF-kappaB in B cells	2.2404959400407e-07	-15.3113984077932	68	42	0.0130071229482812	3229	10285	5684,5693,5704,5700,5718,8915,5695,5709,4793,5689,5579,5707,5690,5683,5694,23291,5687,5691,5685,4790,5699,5686,122706,5705,7979,5698,4792,5713,5721,5716,3551,5720,5692,6500,9861,6233,7311,5710,7314,5702,10213,5682	PSMA3,PSMB5,PSMC4,PSMC1,PSMD12,BCL10,PSMB7,PSMD3,NFKBIB,PSMB1,PRKCB,PSMD1,PSMB2,PSMA2,PSMB6,FBXW11,PSMA6,PSMB3,PSMA4,NFKB1,PSMB10,PSMA5,PSMB11,PSMC5,SEM1,PSMB9,NFKBIA,PSMD7,PSME2,PSMD10,IKBKB,PSME1,PSMB4,SKP1,PSMD6,RPS27A,UBA52,PSMD4,UBB,PSMC3,PSMD14,PSMA1
R-HSA-69304	Regulation of DNA replication	2.48130995043193e-07	-15.2093090244137	77	46	0.0142458965624032	3229	10285	5682,5702,890,5710,4172,6233,5692,9861,5721,23594,7979,5698,51343,5687,5690,5707,1026,84515,5700,5718,51053,10213,5925,7314,7311,5720,5716,5713,5686,5699,122706,5705,5685,4173,5691,5683,5694,4175,5689,5695,5709,5001,5704,1027,5693,5684	PSMA1,PSMC3,CCNA2,PSMD4,MCM3,RPS27A,PSMB4,PSMD6,PSME2,ORC6,SEM1,PSMB9,FZR1,PSMA6,PSMB2,PSMD1,CDKN1A,MCM8,PSMC1,PSMD12,GMNN,PSMD14,RB1,UBB,UBA52,PSME1,PSMD10,PSMD7,PSMA5,PSMB10,PSMB11,PSMC5,PSMA4,MCM4,PSMB3,PSMA2,PSMB6,MCM6,PSMB1,PSMB7,PSMD3,ORC5,PSMC4,CDKN1B,PSMB5,PSMA3
R-HSA-162906	HIV Infection	2.75335853401295e-07	-15.1052741993462	236	111	0.034375967791886	3229	10285	375,160,5691,919,51510,291,5686,902,4331,5431,6873,5478,5716,3836,7311,6917,6879,6881,2958,2963,5436,6827,2959,1234,6882,6749,5700,2071,1025,5045,11097,5690,5707,5687,3159,51534,2968,27183,7251,5432,23636,7979,22916,9525,5062,5692,404672,6233,5710,8905,5702,6880,5682,5684,5693,5704,7852,5709,60489,5695,5689,10762,5694,5683,940,8815,2957,5685,5705,122706,5699,567,5713,2961,1022,6500,9844,5720,5433,5441,2966,7314,5902,8907,10213,5435,6921,292,5718,79023,7520,5901,920,51160,1173,5438,2962,7514,57122,2237,1175,5698,9972,25978,92421,6829,5721,2960,9861,129401,27243	ARF1,AP2A1,PSMB3,CD247,CHMP5,SLC25A4,PSMA5,CCNH,MNAT1,POLR2B,TAF2,PPIA,PSMD10,KPNA1,UBA52,TCEA1,TAF7,TAF10,GTF2A2,GTF2F2,POLR2G,SUPT4H1,GTF2B,CCR5,TAF11,SSRP1,PSMC1,ERCC3,CDK9,FURIN,NUP42,PSMB2,PSMD1,PSMA6,HMGA1,VTA1,GTF2H4,VPS4A,TSG101,POLR2C,NUP62,SEM1,NCBP2,VPS4B,PAK2,PSMB4,GTF2H5,RPS27A,PSMD4,AP1S2,PSMC3,TAF9,PSMA1,PSMA3,PSMB5,PSMC4,CXCR4,PSMD3,APOBEC3G,PSMB7,PSMB1,NUP50,PSMB6,PSMA2,CD28,BANF1,GTF2A1,PSMA4,PSMC5,PSMB11,PSMB10,B2M,PSMD7,GTF2E2,CDK7,SKP1,ELMO1,PSME1,POLR2D,POLR2L,GTF2H2,UBB,RANBP1,AP1M1,PSMD14,POLR2F,ELOC,SLC25A5,PSMD12,NUP37,XRCC5,RAN,CD4,VPS28,AP2M1,POLR2I,GTF2F1,XPO1,NUP107,FEN1,AP2S1,PSMB9,NUP153,CHMP2B,CHMP4C,SUPT5H,PSME2,GTF2E1,PSMD6,NUP35,CHMP2A
R-HSA-1268020	Mitochondrial protein import	3.03294416820137e-07	-15.0085618305316	62	39	0.0120780427376897	3229	10285	51287,100272147,54543,9804,80273,617,150274,56993,10452,131118,100287932,23203,10651,51142,7416,29090,3329,9868,50,54927,131474,291,1537,8604,90639,25813,6901,2395,26517,498,26521,100188893,134266,26519,516,10063,506,1678,10440	COA4,CMC4,TOMM7,TOMM20,GRPEL1,BCS1L,HSCB,TOMM22,TOMM40,DNAJC19,TIMM23,PMPCA,MTX2,CHCHD2,VDAC1,TIMM21,HSPD1,TOMM70,ACO2,CHCHD3,CHCHD4,SLC25A4,CYC1,SLC25A12,COX19,SAMM50,TAFAZZIN,FXN,TIMM13,ATP5F1A,TIMM8B,TOMM6,GRPEL2,TIMM10,ATP5MC1,COX17,ATP5F1B,TIMM8A,TIMM17A
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	3.32867201613713e-07	-14.9155222204582	60	38	0.0117683493341592	3229	10285	5689,5695,84515,5709,5704,5001,5700,5718,5684,5693,5699,5686,122706,5705,5685,5687,5691,5707,5690,5683,5694,5720,5692,9861,5716,5721,23594,5713,7979,5698,5682,51053,5702,10213,5710,7314,6233,7311	PSMB1,PSMB7,MCM8,PSMD3,PSMC4,ORC5,PSMC1,PSMD12,PSMA3,PSMB5,PSMB10,PSMA5,PSMB11,PSMC5,PSMA4,PSMA6,PSMB3,PSMD1,PSMB2,PSMA2,PSMB6,PSME1,PSMB4,PSMD6,PSMD10,PSME2,ORC6,PSMD7,SEM1,PSMB9,PSMA1,GMNN,PSMC3,PSMD14,PSMD4,UBB,RPS27A,UBA52
R-HSA-5387390	Hh mutants abrogate ligand secretion	3.32867201613713e-07	-14.9155222204582	60	38	0.0117683493341592	3229	10285	7314,5710,84447,6233,7311,5682,51009,10213,5702,5713,7979,5698,5692,5720,9861,5721,5716,5687,5691,5694,5683,5690,5707,5699,5686,5705,122706,5685,5700,5704,27248,5718,5693,5684,5689,10956,5695,5709	UBB,PSMD4,SYVN1,RPS27A,UBA52,PSMA1,DERL2,PSMD14,PSMC3,PSMD7,SEM1,PSMB9,PSMB4,PSME1,PSMD6,PSME2,PSMD10,PSMA6,PSMB3,PSMB6,PSMA2,PSMB2,PSMD1,PSMB10,PSMA5,PSMC5,PSMB11,PSMA4,PSMC1,PSMC4,ERLEC1,PSMD12,PSMB5,PSMA3,PSMB1,OS9,PSMB7,PSMD3
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	3.95172792451835e-07	-14.7439427184532	56	36	0.0111489625270982	3229	10285	5686,5699,122706,5705,5685,5687,5691,5707,5690,5694,5683,5689,5695,5709,5704,5700,5718,5684,5693,5682,5702,10213,5710,7314,6233,7311,5720,5692,9861,6500,5721,5716,23194,5713,7979,5698	PSMA5,PSMB10,PSMB11,PSMC5,PSMA4,PSMA6,PSMB3,PSMD1,PSMB2,PSMB6,PSMA2,PSMB1,PSMB7,PSMD3,PSMC4,PSMC1,PSMD12,PSMA3,PSMB5,PSMA1,PSMC3,PSMD14,PSMD4,UBB,RPS27A,UBA52,PSME1,PSMB4,PSMD6,SKP1,PSME2,PSMD10,FBXL7,PSMD7,SEM1,PSMB9
R-HSA-351202	Metabolism of polyamines	4.07943137130308e-07	-14.7121380420338	87	50	0.0154846701765252	3229	10285	5721,9861,5692,5698,7979,6723,1152,5702,5682,4946,5710,5718,5700,4953,6538,4507,5690,5707,51582,5687,5716,6534,51686,5720,6539,5713,1728,10213,4947,57407,2593,384,113451,196743,6535,5709,5695,5689,5693,5684,5704,5685,5705,122706,5686,5699,6303,5683,5694,5691	PSME2,PSMD6,PSMB4,PSMB9,SEM1,SRM,CKB,PSMC3,PSMA1,OAZ1,PSMD4,PSMD12,PSMC1,ODC1,SLC6A11,MTAP,PSMB2,PSMD1,AZIN1,PSMA6,PSMD10,SLC6A7,OAZ3,PSME1,SLC6A12,PSMD7,NQO1,PSMD14,OAZ2,NMRAL1,GAMT,ARG2,AZIN2,PAOX,SLC6A8,PSMD3,PSMB7,PSMB1,PSMB5,PSMA3,PSMC4,PSMA4,PSMC5,PSMB11,PSMA5,PSMB10,SAT1,PSMA2,PSMB6,PSMB3
R-HSA-169911	Regulation of Apoptosis	4.26981703786115e-07	-14.6665246729119	54	35	0.0108392691235677	3229	10285	9861,5062,5720,5692,5721,5716,5713,5698,7979,5682,5702,10213,5710,7314,7311,6233,5689,5709,5695,5718,5704,5700,5684,5693,122706,5705,5699,5686,5685,5691,5687,5707,5690,5683,5694	PSMD6,PAK2,PSME1,PSMB4,PSME2,PSMD10,PSMD7,PSMB9,SEM1,PSMA1,PSMC3,PSMD14,PSMD4,UBB,UBA52,RPS27A,PSMB1,PSMD3,PSMB7,PSMD12,PSMC4,PSMC1,PSMA3,PSMB5,PSMB11,PSMC5,PSMB10,PSMA5,PSMA4,PSMB3,PSMA6,PSMD1,PSMB2,PSMA2,PSMB6
R-HSA-5607764	CLEC7A (Dectin-1) signaling	4.33098117122936e-07	-14.6523015361771	101	56	0.0173428305977083	3229	10285	7189,9861,5692,64581,3551,7321,5721,5698,7979,3553,5682,5702,5710,5530,9040,6233,9020,23118,8915,5718,5700,7334,7335,5687,5707,5690,29108,6714,9039,6500,5720,5716,5713,4792,10213,7314,7311,6850,5689,10768,5709,5695,5704,5693,5684,10454,5705,122706,5699,5686,4790,5685,5691,5683,5694,23291	TRAF6,PSMD6,PSMB4,CLEC7A,IKBKB,UBE2D1,PSME2,PSMB9,SEM1,IL1B,PSMA1,PSMC3,PSMD4,PPP3CA,UBE2M,RPS27A,MAP3K14,TAB2,BCL10,PSMD12,PSMC1,UBE2N,UBE2V1,PSMA6,PSMD1,PSMB2,PYCARD,SRC,UBA3,SKP1,PSME1,PSMD10,PSMD7,NFKBIA,PSMD14,UBB,UBA52,SYK,PSMB1,AHCYL1,PSMD3,PSMB7,PSMC4,PSMB5,PSMA3,TAB1,PSMC5,PSMB11,PSMB10,PSMA5,NFKB1,PSMA4,PSMB3,PSMA2,PSMB6,FBXW11
R-HSA-69615	G1/S DNA Damage Checkpoints	4.4735470111761e-07	-14.6199140421948	67	41	0.0126974295447507	3229	10285	5691,5687,5707,5690,5683,5694,122706,5705,5686,5699,5685,5718,1027,5704,5700,64326,4193,5684,5693,1026,5689,5709,5695,5710,57060,7314,890,7311,6233,5682,10213,5702,7157,5713,5698,7979,9861,5720,5692,5716,5721	PSMB3,PSMA6,PSMD1,PSMB2,PSMA2,PSMB6,PSMB11,PSMC5,PSMA5,PSMB10,PSMA4,PSMD12,CDKN1B,PSMC4,PSMC1,COP1,MDM2,PSMA3,PSMB5,CDKN1A,PSMB1,PSMD3,PSMB7,PSMD4,PCBP4,UBB,CCNA2,UBA52,RPS27A,PSMA1,PSMD14,PSMC3,TP53,PSMD7,PSMB9,SEM1,PSMD6,PSME1,PSMB4,PSMD10,PSME2
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	4.58370191211844e-07	-14.5955887015577	52	34	0.0105295757200372	3229	10285	5704,5700,5718,5684,5693,5689,5695,5709,5687,5691,5690,5707,5683,5694,5699,5686,122706,5705,5685,5713,7979,5698,5720,5692,9861,5716,5721,5710,7314,6233,7311,5682,5702,10213	PSMC4,PSMC1,PSMD12,PSMA3,PSMB5,PSMB1,PSMB7,PSMD3,PSMA6,PSMB3,PSMB2,PSMD1,PSMA2,PSMB6,PSMB10,PSMA5,PSMB11,PSMC5,PSMA4,PSMD7,SEM1,PSMB9,PSME1,PSMB4,PSMD6,PSMD10,PSME2,PSMD4,UBB,RPS27A,UBA52,PSMA1,PSMC3,PSMD14
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	5.75236229446022e-07	-14.368485046699	104	57	0.0176525240012388	3229	10285	9040,5710,6233,5682,8741,7186,5702,7979,5698,5692,9861,5721,329,5687,3604,8995,5690,5707,5700,5718,4050,944,9020,7124,7314,7311,8764,958,10213,5713,9966,5720,959,6500,9039,5716,4049,5691,5694,23291,5683,5699,5686,5705,122706,4055,5685,356,60401,5704,8742,5693,5684,5689,7133,5695,5709	UBE2M,PSMD4,RPS27A,PSMA1,TNFSF13,TRAF2,PSMC3,SEM1,PSMB9,PSMB4,PSMD6,PSME2,BIRC2,PSMA6,TNFRSF9,TNFSF18,PSMB2,PSMD1,PSMC1,PSMD12,LTB,TNFSF8,MAP3K14,TNF,UBB,UBA52,TNFRSF14,CD40,PSMD14,PSMD7,TNFSF15,PSME1,CD40LG,SKP1,UBA3,PSMD10,LTA,PSMB3,PSMB6,FBXW11,PSMA2,PSMB10,PSMA5,PSMC5,PSMB11,LTBR,PSMA4,FASLG,EDA2R,PSMC4,TNFSF12,PSMB5,PSMA3,PSMB1,TNFRSF1B,PSMB7,PSMD3
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	6.1654863577076e-07	-14.2991286273146	61	38	0.0117683493341592	3229	10285	5698,7979,5713,5721,5716,6500,9861,5692,5720,7311,6233,5567,7314,5710,10213,5702,5682,5684,5693,5718,5700,5704,5709,5695,5689,5683,5694,5707,5690,5691,5687,1452,51684,5685,5705,122706,5699,5686	PSMB9,SEM1,PSMD7,PSME2,PSMD10,SKP1,PSMD6,PSMB4,PSME1,UBA52,RPS27A,PRKACB,UBB,PSMD4,PSMD14,PSMC3,PSMA1,PSMA3,PSMB5,PSMD12,PSMC1,PSMC4,PSMD3,PSMB7,PSMB1,PSMA2,PSMB6,PSMD1,PSMB2,PSMB3,PSMA6,CSNK1A1,SUFU,PSMA4,PSMC5,PSMB11,PSMB10,PSMA5
R-HSA-5610783	Degradation of GLI2 by the proteasome	6.1654863577076e-07	-14.2991286273146	61	38	0.0117683493341592	3229	10285	7979,5698,5713,5716,5721,5720,5692,6500,9861,6233,5567,7311,5710,7314,10213,5702,5682,5693,5684,5704,5700,5718,5695,5709,5689,5690,5707,5683,5694,1452,5687,5691,5685,51684,5699,5686,122706,5705	SEM1,PSMB9,PSMD7,PSMD10,PSME2,PSME1,PSMB4,SKP1,PSMD6,RPS27A,PRKACB,UBA52,PSMD4,UBB,PSMD14,PSMC3,PSMA1,PSMB5,PSMA3,PSMC4,PSMC1,PSMD12,PSMB7,PSMD3,PSMB1,PSMB2,PSMD1,PSMA2,PSMB6,CSNK1A1,PSMA6,PSMB3,PSMA4,SUFU,PSMB10,PSMA5,PSMB11,PSMC5
R-HSA-983169	Class I MHC mediated antigen processing & presentation	7.50056285489598e-07	-14.1031175859125	373	161	0.0498606379684113	3229	10285	9554,29945,929,7979,5692,8697,7097,3551,3693,23480,10484,7325,5710,79791,51529,3309,6233,3685,84861,7323,5682,5702,2923,26235,7334,29927,5700,8452,51130,84085,80176,255488,25793,3093,5687,5690,5707,6892,84937,9604,7335,57154,899,9341,79654,7096,390594,26268,54620,25898,10616,4591,948,26224,5716,10533,4360,51665,7311,8673,6396,27338,64410,10333,9870,55070,9021,6737,140460,26249,5691,25847,51128,7328,5686,27246,6477,6468,10075,55294,4615,51343,5698,26118,55658,9861,29882,55521,10193,10273,7321,5721,93611,23376,9040,221687,144699,51132,9616,89890,5718,811,2209,114609,8916,26263,26091,55958,7336,11059,5713,84231,140456,9039,6500,5720,7320,8453,140461,23194,7314,7099,246184,140739,6478,6921,10213,7332,25831,7327,7319,81559,5704,5684,5693,991,22954,84676,5689,8881,8773,5709,29116,5695,114907,80196,7704,7337,10477,55176,10952,5694,23291,5683,122706,5705,567,5699,23643,5685,55284	SEC22B,ANAPC4,CD14,SEM1,PSMB4,CDC23,TLR2,IKBKB,ITGB5,SEC61G,SEC23A,UBE2E2,PSMD4,FBXO31,ANAPC11,HSPA5,RPS27A,ITGAV,KLHL22,UBE2D3,PSMA1,PSMC3,PDIA3,FBXL4,UBE2N,SEC61A1,PSMC1,CUL3,ASB3,FBXO30,SPSB1,RNF144B,FBXO7,UBE2K,PSMA6,PSMB2,PSMD1,TAPBP,ZNRF1,RNF14,UBE2V1,SMURF1,CCNF,VAMP3,HECTD3,TLR1,KBTBD13,FBXO9,FBXL19,RCHY1,RBCK1,TRIM37,CD36,FBXL3,PSMD10,ATG7,MRC1,ASB1,UBA52,VAMP8,SEC13,UBE2S,KLHL25,TLR6,AREL1,DET1,SOCS3,TRIM21,ASB7,KLHL3,PSMB3,ANAPC13,SAR1B,UBE2H,PSMA5,RNF115,SIAH1,FBXW4,HUWE1,FBXW7,MYD88,FZR1,PSMB9,WSB1,RNF126,PSMD6,ANAPC2,TRIM36,RNF41,STUB1,UBE2D1,PSME2,FBXO44,UFL1,UBE2M,RNF182,FBXL14,RLIM,RNF7,KBTBD6,PSMD12,CALR,FCGR1A,TIRAP,HERC3,FBXO22,HERC4,KLHL9,UBE2V2,WWP1,PSMD7,TRAF7,ASB11,UBA3,SKP1,PSME1,UBE2B,CUL2,ASB8,FBXL7,UBB,TLR4,CDC26,UBE2F,SIAH2,ELOC,PSMD14,UBE2L3,HECTD1,UBE2G2,UBE2A,TRIM11,PSMC4,PSMA3,PSMB5,CDC20,TRIM32,TRIM63,PSMB1,CDC16,SNAP23,PSMD3,MYLIP,PSMB7,FBXO32,RNF34,ZBTB16,UBE3A,UBE2E3,SEC61A2,SEC61B,PSMB6,FBXW11,PSMA2,PSMB11,PSMC5,B2M,PSMB10,LY96,PSMA4,UBE2W
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	9.67877005419503e-07	-13.8481608182597	51	33	0.0102198823165067	3229	10285	122706,5705,5686,5699,5685,5691,5687,5707,5690,5683,5694,5689,5709,5695,5718,5704,5700,5693,5684,2209,5682,5702,10213,5710,4360,9861,5720,5692,5721,5716,5713,5698,7979	PSMB11,PSMC5,PSMA5,PSMB10,PSMA4,PSMB3,PSMA6,PSMD1,PSMB2,PSMA2,PSMB6,PSMB1,PSMD3,PSMB7,PSMD12,PSMC4,PSMC1,PSMB5,PSMA3,FCGR1A,PSMA1,PSMC3,PSMD14,PSMD4,MRC1,PSMD6,PSME1,PSMB4,PSME2,PSMD10,PSMD7,PSMB9,SEM1
R-HSA-2262752	Cellular responses to stress	9.71298161432079e-07	-13.8446323494339	451	189	0.0585320532672654	3229	10285	2877,10762,5689,57805,10049,8881,5704,1019,3569,6648,122706,5685,2056,6009,9821,8970,10587,51182,5683,5694,5720,8453,85236,5606,10213,5925,7314,6015,60673,79065,79023,2876,5718,119504,55766,3014,8726,1021,10670,25906,112399,3281,6119,92421,9972,6667,5698,8655,8331,10325,8345,9973,5052,84557,3326,257202,3397,3024,2288,112398,4790,55054,7296,8342,2880,3552,5716,2878,6647,25842,4343,3007,57690,8649,5608,5571,7290,5700,1387,11152,6767,3159,9588,3320,5707,5690,11097,10013,8697,51501,8335,4683,23636,5682,5710,2146,318,8350,11337,2950,5695,5709,1027,1032,2353,5693,5684,5699,27000,7295,5705,3725,8348,7001,6118,26523,9532,5713,6921,3576,3312,246184,94239,64422,7867,1026,3013,55004,5602,3015,1915,57122,5928,9531,10728,8550,29882,9861,5721,7321,3456,25978,3009,51343,23710,1031,6649,255626,27243,890,7029,129401,81631,23043,5931,4193,5686,5691,2882,115201,7266,2033,30001,10533,7311,818,474382,1911,11345,6782,28956,5687,8678,5692,29855,84938,29945,7422,5564,7979,8334,7323,5702,7157,51529,4001,6233,3309,10935	GPX2,NUP50,PSMB1,CCAR2,DNAJB6,CDC16,PSMC4,CDK4,IL6,SOD2,PSMB11,PSMA4,EPO,RHEB,RB1CC1,H2BC11,TXNRD2,HSPA14,PSMA2,PSMB6,PSME1,CUL2,H2BC12,MAP2K3,PSMD14,RB1,UBB,RING1,ATG101,ATG9A,NUP37,GPX1,PSMD12,ANAPC16,H2AJ,H2AX,EED,CDK6,RRAGA,ANAPC15,EGLN3,HSBP1,RPA3,CHMP4C,NUP153,SP1,PSMB9,DYNLL1,H2AC14,RRAGB,H2BC9,CCS,PRDX1,MAP1LC3A,HSP90AB1,GPX6,ID1,H1-1,FKBP4,EGLN2,NFKB1,ATG16L1,TXNRD1,H2BC14,GPX5,IL1A,PSMD10,GPX3,SOD1,ASF1A,MOV10,H1-3,TNRC6C,LAMTOR3,MAP2K6,PRKAG1,HIRA,PSMC1,CREBBP,WDR45,ST13,HMGA1,PRDX6,HSP90AA1,PSMD1,PSMB2,NUP42,HDAC6,CDC23,HIKESHI,H2AC4,NBN,NUP62,PSMA1,PSMD4,EZH2,NUDT2,H3C1,GABARAP,GSTP1,PSMB7,PSMD3,CDKN1B,CDKN2D,FOS,PSMB5,PSMA3,PSMB10,DNAJC2,TXN,PSMC5,JUN,H2BC17,PRDX2,RPA2,AGO1,BAG2,PSMD7,ELOC,CXCL8,HSPA8,CDC26,H2AZ2,ATG3,MAPKAPK3,CDKN1A,H2AC7,LAMTOR1,MAPK10,H2AZ1,EEF1A1,NUP107,RBBP4,BAG3,PTGES3,MAPKAPK5,ANAPC2,PSMD6,PSME2,UBE2D1,IFNB1,CHMP2B,H1-5,FZR1,GABARAPL1,CDKN2C,SOD3,H2BC1,CHMP2A,CCNA2,TFDP2,NUP35,MAP1LC3B,TNIK,RBBP7,MDM2,PSMA5,PSMB3,GPX7,ATG4A,DNAJC7,EP300,ERO1A,ATG7,UBA52,CAMK2G,H2AB1,PHC1,GABARAPL2,HSPA13,LAMTOR2,PSMA6,BECN1,PSMB4,UBN1,ATG4C,ANAPC4,VEGFA,PRKAB1,SEM1,H2AC6,UBE2D3,PSMC3,TP53,ANAPC11,LMNB1,RPS27A,HSPA5,PRDX3
R-HSA-168256	Immune System	1.01141825118139e-06	-13.8041570030002	2101	751	0.232579746051409	3229	10285	714,4973,23291,3702,1742,1075,1385,22954,5295,6363,8350,1027,7850,64114,7076,7319,6921,7099,3312,245934,5536,26523,10810,149954,4599,90423,941,10875,8822,63916,148022,5878,55958,1173,10043,4793,2204,8916,7867,920,374383,5602,23650,10346,3577,9616,5530,4747,23376,55521,29882,51343,200734,4615,2207,51348,528,54106,5691,5037,7525,6616,2171,6804,6590,7529,53840,6773,4860,27338,6396,3586,1271,11240,317649,10817,3574,55754,1852,9966,131450,9341,81603,909,899,7130,3601,51209,146433,534,10628,11333,9020,1672,818,84085,51130,3240,29927,7157,942,54739,23646,5770,1072,1958,23406,7325,5547,114548,25801,55703,3429,5870,1845,23586,10121,9145,51382,7422,5685,177,5694,25840,991,917,6347,5689,7133,10768,5704,25831,3662,5873,5781,5265,171568,5441,11006,6776,7124,57162,8453,4049,5269,53358,3383,3604,1660,79023,5579,5610,1437,944,3716,55832,4296,10870,3728,144699,9040,329,7726,55658,9972,3559,6468,4790,4233,3726,4055,10075,51135,5273,8394,3552,10010,3797,25847,1774,2002,4600,55070,9870,7220,8742,81793,27006,10616,595,54620,3163,196051,6778,966,4153,3665,5707,6892,10695,10787,3669,1780,1509,115004,8905,5682,79791,3459,25780,1513,2040,9554,55284,4692,58480,55176,50616,5611,8560,55223,2950,5693,2353,109,23087,10068,910,5567,3576,79980,959,80228,140456,10159,55128,5819,2690,29127,11059,8887,3074,4205,1026,3838,3384,2252,533,961,64837,51132,23593,4758,221687,8878,8778,1839,26191,10576,51311,140460,375,245937,4193,1781,84292,10666,8554,3836,390594,2033,2255,28956,1235,26999,8174,10000,6041,3592,80176,10094,1938,2923,8870,80128,161742,10484,353376,3146,22931,3824,122706,6364,10952,51517,3565,8881,8773,1460,4282,29116,3717,10762,84676,3569,6657,4179,820,7332,5663,91543,51806,5518,140461,11027,9550,3608,5617,245928,58485,10621,1278,7128,2931,9402,23197,10193,7189,5698,7462,3600,2537,9021,60,2212,5627,9636,6402,965,6786,246330,51665,4718,51561,6348,3659,4345,4831,79654,6093,5516,57154,604,10120,7335,3796,11097,5690,203068,53833,8682,3606,120425,374395,5700,84861,3562,5245,4988,6464,8835,4069,8697,6356,23636,374403,1493,1785,6279,3558,3725,7305,567,7337,940,8315,1445,25939,11026,3920,3636,9976,3660,246184,5578,9655,80380,25798,23385,1915,1175,22875,26263,4311,5495,57122,6772,5476,466,9775,51719,8503,4050,4609,1974,22861,89890,11031,11221,5721,10671,10273,7184,3456,356,837,3440,5686,51128,160,1977,51164,919,3458,29851,998,10333,64410,25852,1508,8764,10612,5266,4360,26224,6714,6727,26268,51284,7534,4792,29110,5478,3815,3567,79837,25793,3093,84265,8823,7450,3446,57826,26235,823,7334,10549,10385,7323,327,3309,1442,6233,3556,51529,3693,1471,64581,1843,5236,3822,2683,2260,5683,10477,108,80196,7410,975,10213,5435,958,6478,3937,6711,5775,5896,9844,140683,284,7320,5153,5606,3385,3394,10694,5581,7520,8635,7098,811,684,572,3553,967,29126,51125,93611,9470,3627,4620,152559,7328,3428,5296,3561,4938,3326,1848,2688,1154,3845,8673,10577,57690,57506,948,829,2268,2495,7096,3958,245929,974,5049,729230,6836,11010,207,5290,3320,8915,23118,245930,5608,1234,8452,5008,80143,598,10383,10379,5705,94103,7295,5699,911,3430,5709,114907,5695,51316,5684,2919,7276,81559,10857,8907,867,23194,64135,6500,9039,3593,1992,5713,7336,9545,26091,54918,5906,5223,114609,55004,56729,140881,10538,4502,11024,129401,7321,85363,9861,80331,8836,326624,10107,6282,4215,2220,60401,8074,93978,5136,4068,5529,259197,5864,3447,6352,1727,391,6285,5525,5588,5908,7311,30835,10533,10235,4277,25898,23412,4591,118788,2549,5834,1116,9342,84937,9604,912,6039,5687,255488,4170,3560,2665,9371,3664,5702,3454,7186,54472,117854,5692,523,7979,929,8904,29945,11258,23643,7100,5133,112744,7704,1399,1230,29099,5912,7327,4208,140739,7314,3043,5720,947,4690,51082,84231,208,1191,29108,8995,3572,1113,8976,2512,3661,2209,5718,92747,8655,23098,10396,2248,2213,26118,55294,6477,27246,12,10097,5728,6709,26249,8987,6737,10454,332,116842,84418,340205,2246,51552,80301,5604,8992,6850,80263,5894,830,10859,5716,6386,3596,4343,5371,258010,4318,3265,9588,3433,175,51646,7341,8649,1387,6515,1499,8741,10109,1476,3685,5710,23480,7097,3551,5062,3417	C1QC,OLR1,FBXW11,ITK,DLG4,CTSC,CREB1,TRIM32,PIK3R1,CCL19,H3C1,CDKN1B,IL1R2,TMBIM1,TIMP1,UBE2A,ELOC,TLR4,HSPA8,DEFB121,PPP5C,AGO1,WASF3,BPIFB4,MX1,ATP6V1E2,CD80,FGL2,FGF17,ELMO2,TICAM1,RAB5C,KLHL9,AP2M1,TOM1,NFKBIB,FCAR,HERC3,MAPKAPK3,CD4,NCR3LG1,MAPK10,TRIM29,TRIM22,CXCR1,RNF7,PPP3CA,NEFL,UFL1,TRIM36,ANAPC2,FZR1,SPRED2,MYD88,FCER1G,KLRF1,ATP6V1C1,TLR9,PSMB3,PEBP1,YES1,SNAP25,FABP5,STX1A,SLPI,YWHAB,TRIM34,STAT2,PNP,UBE2S,SEC13,IL10,CNTFR,PADI2,EIF4E3,FRS3,IL7,TMEM30A,DUSP9,TNFSF15,CD200R1,VAMP3,TRIM8,CD1A,CCNF,TNFAIP6,IL15RA,RAB9B,IL34,ATP6V1G2,TXNIP,PDAP1,MAP3K14,DEFB1,CAMK2G,FBXO30,ASB3,HP,SEC61A1,TP53,CD86,XAF1,PLD3,PTPN1,CFL1,EGR1,COTL1,UBE2E2,PRCP,NLRP3,GCA,POLR3B,IFI27,RAB6A,DUSP3,RIGI,ACTR1A,SYNGR1,ATP6V1D,VEGFA,PSMA4,AGER,PSMB6,TMT1A,CDC20,CD3G,CCL2,PSMB1,TNFRSF1B,AHCYL1,PSMC4,HECTD1,IRF4,RAB27A,PTPN11,SERPINA1,POLR3H,POLR2L,LILRB4,STAT5A,TNF,PELI1,CUL2,LTA,SERPINB6,SHC3,ICAM1,TNFRSF9,DHX9,NUP37,PRKCB,EIF2AK2,CSF2,TNFSF8,JAK1,CAND1,MAP3K11,HCST,JUP,FBXL14,UBE2M,BIRC2,TRIM26,RNF126,NUP153,IL2RA,FBXW4,NFKB1,MET,JUNB,LTBR,HUWE1,IRAK4,SERPINB10,PIP5K1A,IL1A,TANK,KIF3C,ANAPC13,DNASE1L1,ELK1,MX2,DET1,AREL1,TRPC1,TNFSF12,TLR10,FGF22,RBCK1,CCND1,FBXL19,HMOX2,PLPP4,STAT6,CD59,MBL2,IRF7,PSMD1,TAPBP,CNPY3,NCKAP1,ISG20,DYNC1I1,CTSD,CGAS,AP1S2,PSMA1,FBXO31,IFNGR1,RASGRP3,CTSK,STOM,SEC22B,UBE2W,NDN,RHOU,SEC61A2,IL22,DNAJC3,DEGS1,TRIM62,GSTP1,PSMB5,FOS,ADCY3,TRIM35,IL18BP,CD1B,PRKACB,CXCL8,DSN1,CD40LG,ORAI2,ASB11,ATP6AP2,TRIM68,NECTIN2,GHR,RACGAP1,WWP1,TAX1BP1,HEXB,MEF2A,CDKN1A,KPNA2,ICAM2,FGF7,ATP6V0B,CD47,KLC2,RLIM,HEBP2,NEU1,RNF182,SQSTM1,SIGLEC5,HBEGF,PTPN22,CCT2,TLR8,ASB7,ARF1,DEFB124,MDM2,DYNC1I2,WDR83,CD226,PIAS1,KPNA1,KBTBD13,EP300,FGF10,LAMTOR2,CCR6,CYFIP2,MADCAM1,AKT3,RNASEL,IL12A,SPSB1,ARPC3,EEF2,PDIA3,IER3,TRIM46,SPRED1,SEC23A,TICAM2,HMGB1,RAB18,KLRD1,PSMB11,CCL20,SEC61B,NCKIPSD,IL4,CDC16,SNAP23,CSNK2B,MIF,MYLIP,JAK2,NUP50,TRIM63,IL6,SOX2,CD46,CAMP,UBE2L3,PSEN1,RSAD2,CALML5,PPP2R1A,ASB8,LILRA2,ATP6V1G1,ILF2,PRL,DEFB114,TRAPPC1,POLR3F,COL1A2,TNFAIP3,GSK3A,GRAP2,FAF2,RNF41,TRAF6,PSMB9,LAT2,IL15,IFI6,SOCS3,ACTB,FCGR2A,PROS1,ISG15,SELL,CD58,STIM1,PELI3,ASB1,NDUFC2,IL23A,CCL3,IRF1,CD200,NME2,HECTD3,ROCK1,PPP2CB,SMURF1,BCL6,ACTR1B,UBE2V1,KIF2A,NUP42,PSMB2,TUBB,IL20RB,PEA15,IL18,JAML,TMEM179B,PSMC1,KLHL22,IL3,PHB1,OPRM1,SHC1,SOCS2,LYZ,CDC23,CCL11,NUP62,TBC1D10C,CTLA4,DNM2,S100A8,IL2,JUN,TYROBP,B2M,UBE3A,CD28,BRAP,CSK,SAMHD1,LILRA3,LAMP2,INPPL1,CLEC2B,IRF2,CDC26,PRKCA,SOCS5,PDCD1LG2,BRI3,NCSTN,EEF1A1,AP2S1,ENPP4,FBXO22,MME,PPM1B,NUP107,STAT1,CTSA,ATF1,EIF4A3,CAB39,PIK3R3,LTB,MYC,EIF4A2,NLRP1,KBTBD6,RAB31,DUSP10,PSME2,DCTN6,STUB1,HSP90B1,IFNB1,FASLG,CASP4,IFNA2,PSMA5,SAR1B,AP2A1,EIF4E,DCTN4,CD247,IFNG,ICOS,CDC42,TLR6,KLHL25,ARMC8,CTSB,TNFRSF14,TRIM3,PI3,MRC1,FBXL3,SRC,SRP14,FBXO9,TLR7,YWHAZ,NFKBIA,TBK1,PPIA,KIT,IL5,PIP4K2C,FBXO7,UBE2K,POLR3GL,FGF16,VWF,IFNA10,RAP2C,FBXL4,CAPN1,UBE2N,PRDX4,BTN2A2,UBE2D3,APEH,HSPA5,CSH1,RPS27A,IL1RAP,ANAPC11,ITGB5,CST3,CLEC7A,DUSP1,PGM1,KLRC2,B4GALT1,FGFR1,PSMA2,UBE2E3,ADCY2,RNF34,VAV2,CD81,PSMD14,POLR2F,CD40,SIAH2,LCP2,SPTBN1,PTPN4,RAG1,ELMO1,BPIFA2,ANGPT1,UBE2B,PDE1B,MAP2K3,ICAM3,IRF8,CCT8,PRKCE,XRCC5,RNASET2,TLR3,CALR,BST2,BAD,IL1B,CD63,CD274,GOLGA7,FBXO44,EIF4E2,CXCL10,MYH2,PAQR3,UBE2H,IFI16,PIK3R2,IL2RG,OAS1,HSP90AB1,DUSP6,GH1,CISH,KRAS,VAMP8,NPC2,TNRC6C,MAVS,CD36,CAPZA1,FGR,FTH1,TLR1,LGALS3,DEFB115,CD79B,PAFAH1B2,CCR2,SURF4,GLIPR1,AKT1,PIK3CA,HSP90AA1,BCL10,TAB2,DEFB116,MAP2K6,CCR5,CUL3,OSM,SIKE1,BCL2L1,TUBB4B,IRF9,PSMC5,ORMDL3,TXN,PSMB10,CD1C,IFI35,PSMD3,FBXO32,PSMB7,PLAC8,PSMA3,CXCL1,TTR,TRIM11,PGRMC1,AP1M1,CBL,FBXL7,IFIH1,SKP1,UBA3,IL12B,SERPINB1,PSMD7,UBE2V2,RAB3D,HERC4,CMTM6,RAP1A,PGAM1,TIRAP,LAMTOR1,RETN,DEFB129,BATF,MT2A,LILRA1,NUP35,UBE2D1,TRIM5,PSMD6,DNAJC5,GGH,RAB37,TRIM10,S100A11,MAP3K3,FCN2,EDA2R,FGF23,CLEC6A,PDE1A,SH2D1A,PPP2R5E,NCR3,RAB3A,IFNA13,CCL5,CYB5R3,RHOG,S100B,PPP2R5A,PRKCQ,RAP1B,UBA52,CD209,ATG7,RASGRP2,MICB,RCHY1,COMMD3,TRIM37,PIK3AP1,GAB1,PYGB,CHI3L1,SNAP29,ZNRF1,RNF14,CD1D,RNASE6,PSMA6,RNF144B,MCL1,IL2RB,GDI2,KIF3B,IRF6,PSMC3,IFNAR1,TRAF2,TOLLIP,TRIM6,PSMB4,ATP6V1A,SEM1,CD14,CPNE1,ANAPC4,DCTN3,LY96,TLR5,PDCD1,IL17F,ZBTB16,CRKL,CCR1,COMMD9,RAP2B,UBE2G2,MEF2C,UBE2F,UBB,HBB,PSME1,CD34,NCK1,POLR1D,TRAF7,AKT2,CLU,PYCARD,TNFSF18,IL6ST,CHGA,WASL,FTL,IRF3,FCGR1A,PSMD12,BPIFB1,DYNLL1,SARM1,ATP8A1,FGF3,FCGR2B,WSB1,FBXW7,SIAH1,RNF115,SERPINA3,ACTR2,PTEN,SPTAN1,KLHL3,STBD1,TRIM21,TAB1,BIRC5,LEAP2,CYSTM1,TREML1,FGF1,RAB14,PLEKHO2,MAP2K1,ATP6V0E1,SYK,TRIM45,RAF1,CAPZA2,LILRB1,PSMD10,SDCBP,IL13,MOV10,PML,SVIP,MMP9,HRAS,PRDX6,IFIT2,AGA,YPEL5,SUMO1,LAMTOR3,CREBBP,SLC2A3,CTNNB1,TNFSF13,ARPC2,CSTB,ITGAV,PSMD4,SEC61G,TLR2,IKBKB,PAK2,IDH1
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	1.23228843706185e-06	-13.6066375992632	113	60	0.0185816042118303	3229	10285	84987,7384,1340,4712,55863,9481,10476,2109,10975,27089,4718,4697,51241,539,515,10632,6391,116228,7385,91942,513,9377,4729,4698,498,1327,51204,514,506,4710,4726,4695,137682,29078,1349,7351,80219,55967,4728,4706,518,4694,4722,6390,51300,1345,25915,4720,1351,1537,4716,4713,9016,1353,516,7388,2108,4714,522,4711	COX14,UQCRC1,COX6B1,NDUFB6,TMEM126B,SLC25A27,ATP5PD,ETFB,UQCR11,UQCRQ,NDUFC2,NDUFA4,COX16,ATP5PO,ATP5PB,ATP5MG,SDHC,COX20,UQCRC2,NDUFAF2,ATP5F1D,COX5A,NDUFV2,NDUFA5,ATP5F1A,COX4I1,TACO1,ATP5F1E,ATP5F1B,NDUFB4,NDUFS6,NDUFA2,NDUFAF6,NDUFAF4,COX7B,UCP2,COQ10B,NDUFA12,NDUFS8,NDUFAB1,ATP5MC3,NDUFA1,NDUFS3,SDHB,TIMMDC1,COX6C,NDUFAF3,NDUFS2,COX8A,CYC1,NDUFB10,NDUFB7,SLC25A14,COX11,ATP5MC1,UQCRH,ETFA,NDUFB8,ATP5PF,NDUFB5
R-HSA-68867	Assembly of the pre-replicative complex	1.35299964495055e-06	-13.5131864711921	69	41	0.0126974295447507	3229	10285	5682,51053,5702,10213,5710,4172,7314,6233,7311,5720,5692,9861,5721,5716,23594,5713,7979,5698,5699,5686,122706,5705,5685,4173,5687,5691,5690,5707,5683,4175,5694,5689,5695,84515,5709,5704,5001,5700,5718,5693,5684	PSMA1,GMNN,PSMC3,PSMD14,PSMD4,MCM3,UBB,RPS27A,UBA52,PSME1,PSMB4,PSMD6,PSME2,PSMD10,ORC6,PSMD7,SEM1,PSMB9,PSMB10,PSMA5,PSMB11,PSMC5,PSMA4,MCM4,PSMA6,PSMB3,PSMB2,PSMD1,PSMA2,MCM6,PSMB6,PSMB1,PSMB7,MCM8,PSMD3,PSMC4,ORC5,PSMC1,PSMD12,PSMB5,PSMA3
R-HSA-4608870	Asymmetric localization of PCP proteins	1.53385569370354e-06	-13.3877259313455	67	40	0.0123877361412202	3229	10285	5693,5684,5704,5700,5718,5695,5709,1856,5689,50855,5690,5707,5694,5683,5687,5691,5685,57154,5699,5686,122706,5705,7979,5698,5713,5721,5716,8322,5720,5692,9861,6233,7976,7311,100126338,5710,7314,5702,10213,5682	PSMB5,PSMA3,PSMC4,PSMC1,PSMD12,PSMB7,PSMD3,DVL2,PSMB1,PARD6A,PSMB2,PSMD1,PSMB6,PSMA2,PSMA6,PSMB3,PSMA4,SMURF1,PSMB10,PSMA5,PSMB11,PSMC5,SEM1,PSMB9,PSMD7,PSME2,PSMD10,FZD4,PSME1,PSMB4,PSMD6,RPS27A,FZD3,UBA52,MIR937,PSMD4,UBB,PSMC3,PSMD14,PSMA1
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	1.53385569370354e-06	-13.3877259313455	67	40	0.0123877361412202	3229	10285	5702,10213,5682,7323,6921,6233,7311,5710,7314,112399,5721,7321,5716,8453,5720,5692,9861,7979,5698,5713,5685,5699,5686,112398,122706,5705,5690,5707,5683,5694,5687,5691,5695,5709,5689,5693,5684,5704,5700,5718	PSMC3,PSMD14,PSMA1,UBE2D3,ELOC,RPS27A,UBA52,PSMD4,UBB,EGLN3,PSME2,UBE2D1,PSMD10,CUL2,PSME1,PSMB4,PSMD6,SEM1,PSMB9,PSMD7,PSMA4,PSMB10,PSMA5,EGLN2,PSMB11,PSMC5,PSMB2,PSMD1,PSMA2,PSMB6,PSMA6,PSMB3,PSMB7,PSMD3,PSMB1,PSMB5,PSMA3,PSMC4,PSMC1,PSMD12
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	1.68762225247392e-06	-13.2921899709133	54	34	0.0105295757200372	3229	10285	7311,6233,5710,7314,5702,10213,5682,5698,7979,5713,5721,5716,9861,5720,5692,5707,5690,5683,5694,5691,5687,5685,122706,5705,5699,5686,5684,5693,5718,5704,5700,5709,5695,5689	UBA52,RPS27A,PSMD4,UBB,PSMC3,PSMD14,PSMA1,PSMB9,SEM1,PSMD7,PSME2,PSMD10,PSMD6,PSME1,PSMB4,PSMD1,PSMB2,PSMA2,PSMB6,PSMB3,PSMA6,PSMA4,PSMB11,PSMC5,PSMB10,PSMA5,PSMA3,PSMB5,PSMD12,PSMC4,PSMC1,PSMD3,PSMB7,PSMB1
R-HSA-69610	p53-Independent DNA Damage Response	1.68762225247392e-06	-13.2921899709133	54	34	0.0105295757200372	3229	10285	7314,5710,7311,6233,5682,10213,5702,5713,5698,7979,9861,5692,5720,5721,5716,5691,5687,5694,5683,5707,5690,5705,122706,5699,5686,5685,5718,5700,5704,5684,5693,5689,5709,5695	UBB,PSMD4,UBA52,RPS27A,PSMA1,PSMD14,PSMC3,PSMD7,PSMB9,SEM1,PSMD6,PSMB4,PSME1,PSME2,PSMD10,PSMB3,PSMA6,PSMB6,PSMA2,PSMD1,PSMB2,PSMC5,PSMB11,PSMB10,PSMA5,PSMA4,PSMD12,PSMC1,PSMC4,PSMA3,PSMB5,PSMB1,PSMD3,PSMB7
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	1.68762225247392e-06	-13.2921899709133	54	34	0.0105295757200372	3229	10285	5700,5704,5718,5693,5684,5689,5695,5709,5687,5691,5683,5694,5690,5707,5686,5699,5705,122706,5685,5713,7979,5698,5692,5720,9861,5716,5721,7314,5710,6233,7311,5682,10213,5702	PSMC1,PSMC4,PSMD12,PSMB5,PSMA3,PSMB1,PSMB7,PSMD3,PSMA6,PSMB3,PSMA2,PSMB6,PSMB2,PSMD1,PSMA5,PSMB10,PSMC5,PSMB11,PSMA4,PSMD7,SEM1,PSMB9,PSMB4,PSME1,PSMD6,PSMD10,PSME2,UBB,PSMD4,RPS27A,UBA52,PSMA1,PSMD14,PSMC3
R-HSA-380108	Chemokine receptors bind chemokines	2.19588998680197e-06	-13.0289231326566	48	31	0.00960049550944565	3229	10285	6346,7852,6366,2919,6352,1230,1234,6363,56477,2921,1233,1236,6364,1235,10663,729230,6387,4283,1524,6376,6375,57007,6373,3627,3576,10850,3577,1232,2833,6370,10563	CCL1,CXCR4,CCL21,CXCL1,CCL5,CCR1,CCR5,CCL19,CCL28,CXCL3,CCR4,CCR7,CCL20,CCR6,CXCR6,CCR2,CXCL12,CXCL9,CX3CR1,CX3CL1,XCL1,ACKR3,CXCL11,CXCL10,CXCL8,CCL27,CXCR1,CCR3,CXCR3,CCL25,CXCL13
R-HSA-5610780	Degradation of GLI1 by the proteasome	2.20519503188444e-06	-13.0246946031427	61	37	0.0114586559306287	3229	10285	5687,5691,5690,5707,5694,5683,5699,5686,122706,5705,5685,51684,5704,5700,5718,5693,5684,5689,5695,5709,5710,7314,6233,5567,7311,5682,10213,5702,5713,7979,5698,5720,5692,6500,9861,5716,5721	PSMA6,PSMB3,PSMB2,PSMD1,PSMB6,PSMA2,PSMB10,PSMA5,PSMB11,PSMC5,PSMA4,SUFU,PSMC4,PSMC1,PSMD12,PSMB5,PSMA3,PSMB1,PSMB7,PSMD3,PSMD4,UBB,RPS27A,PRKACB,UBA52,PSMA1,PSMD14,PSMC3,PSMD7,SEM1,PSMB9,PSME1,PSMB4,SKP1,PSMD6,PSMD10,PSME2
R-HSA-597592	Post-translational protein modification	2.2069774921504e-06	-13.023886629133	1034	391	0.121090120780427	3229	10285	11047,8329,3093,2155,8678,51209,8702,79139,29086,7334,2159,8334,3703,7323,9960,51762,7157,5868,9363,6233,632,81847,2590,5870,8078,114548,338328,2683,151194,672,23586,7329,2762,51128,5686,11021,9097,51164,5691,23256,11070,51560,22845,2890,221613,6396,79644,27338,4088,6881,56648,5876,4792,1069,5878,1915,116150,57122,51651,4086,10474,5476,10026,4738,4609,255626,9804,10418,5887,11282,11031,79589,91833,10671,5721,11320,7070,285381,100313843,8348,8774,1075,11236,86,51715,90268,7703,89978,11014,51602,10282,8703,7264,7319,51009,3312,9527,81794,8693,23627,256435,9230,966,79594,5707,5872,55738,5045,8915,7903,84749,6484,1780,4089,5682,79090,9037,7991,116442,122553,6612,7353,9554,10113,9570,7328,9868,8342,92815,5865,8073,5279,2530,283899,56254,2158,57506,9656,11316,55907,205564,2677,10175,257194,3416,390243,7416,55741,80070,503542,1725,51255,3190,79023,10600,8607,811,29954,8331,5862,29844,254013,8818,8345,51272,329,284098,10342,9146,9972,115827,51299,5685,29925,25950,26503,10477,5683,5694,5689,991,196483,5704,55014,6613,6478,6048,5873,56160,10213,6811,2109,6015,5265,5373,7320,6711,8934,10905,29880,64409,55343,57559,5687,6483,64841,7109,29906,8975,51611,378,1911,2923,1938,79091,3998,7186,57403,29071,5702,367,7150,5692,3972,10484,22931,9510,7979,27430,9245,9810,375,5864,120526,9986,27095,10617,1781,7347,4193,401409,79609,7048,80740,7311,8554,2033,56957,5867,7844,5277,9545,125476,9929,9117,3013,1043,5111,890,4758,129401,326624,9861,2673,4286,7321,80351,9526,1798,5699,5705,55284,4087,5423,8658,10956,5695,5709,6675,407043,5693,5684,55777,6482,51399,84447,9382,9331,2589,249,10652,64135,9958,5713,23423,8766,440138,7341,5690,11097,2350,83475,5700,8724,2348,8733,4597,5710,9215,10981,29926,83452,6184,10559,8335,10945,10678,23636,5728,372,6709,3183,123228,10454,332,5627,60,5885,51014,2147,51552,23193,8869,5716,4253,5371,9486,80349,54732,51226,79577,26286,10670,58485,220441,1080,7128,5718,8790,27314,9099,8655,80267,85365,7189,9695,140838,5698,26984,11041,1605,4062,1048,122706,11258,22944,1603,8970,7417,10762,8314,5861,154,81876,4245,6480,8775,79672,51693,6187,84628,7332,7327,7155,7314,79695,9367,5720,23770,9101,85236	ADRM1,H2AC13,UBE2K,F7,BECN1,RAB9B,B4GALT4,DERL1,BABAM1,UBE2N,F10,H2AC6,STT3A,UBE2D3,USP3,RAB8B,TP53,RAB5A,RAB33A,RPS27A,BGLAP,RNF146,GALNT2,RAB6A,USP5,NLRP3,GPIHBP1,B4GALT1,METTL21A,BRCA1,RIGI,UBE2I,GMDS,SAR1B,PSMA5,RAB35,USP14,DCTN4,PSMB3,SCFD1,TMEM115,RAB6B,DOLK,GRIA1,H2AC1,SEC13,SRD5A3,UBE2S,SMAD3,TAF10,EIF5A2,RABGGTB,NFKBIA,CETN2,RAB5C,EEF1A1,NUS1,NUP107,PTRH2,SMAD1,TADA3,CTSA,PIGK,NEDD8,MYC,H2BC1,TOMM20,SPON1,RAD23B,MGAT4B,RAB31,RNF128,WDR20,DCTN6,PSME2,MGAT4A,THY1,DPH3,MIR711,H2BC17,NAPG,CTSC,RNF139,ACTL6A,RAB23,OTULIN,PCGF2,DPH6,KDELR2,NOP58,BET1,B4GALT3,GFUS,UBE2A,DERL2,HSPA8,GOSR1,ADAMTS10,GALNT4,PRND,ST6GALNAC3,RAB11B,CD59,MUL1,PSMD1,RAB13,ARFGAP1,FURIN,BCL10,ST8SIA4,USP30,ST3GAL4,DYNC1I1,SMAD4,PSMA1,TRAPPC6A,SEMA5A,TUSC3,RAB39B,TRAPPC6B,SUMO3,UFD1,SEC22B,PREB,GOSR2,UBE2H,TOMM70,H2BC14,H2AC25,RAB3B,PTP4A2,PIGC,FUT8,INO80E,RNF20,F9,MAVS,MDC1,COPE,CMAS,SENP5,GGCX,CNIH1,NEGR1,IDE,IZUMO1R,VDAC1,EDEM2,ADAMTS20,SPRN,DHPS,RNF181,HNRNPK,NUP37,USP16,RUVBL1,CALR,POMT2,H2AC14,RAB2A,TFPT,ETFBKMT,DPM2,H2BC9,BET1L,BIRC2,PIGW,TFG,HGS,NUP153,RAB3C,NRN1,PSMA4,GMPPB,RWDD3,SLC17A5,UBE2E3,PSMA2,PSMB6,PSMB1,CDC20,EEF2KMT,PSMC4,STX17,SUMO2,SIAH2,RNF5,RAB27A,NSMCE3,PSMD14,STX5,ETFB,RING1,SERPINA1,PMM2,UBE2B,SPTBN1,RAB29,MAN1A2,ALG5,GALNT17,SLC35C1,STAMBPL1,PSMA6,ST3GAL2,GNPNAT1,TRAPPC10,ST8SIA5,USP13,DPH5,ARF4,PHC1,PDIA3,EEF2,METTL22,LMAN1,TRAF2,RAB22A,C1GALT1C1,PSMC3,AR,TOP1,PSMB4,LHB,SEC23A,RAB18,ADAMTS1,SEM1,MAT2B,GCNT3,RNF40,ARF1,RAB3A,DNAJC24,RCE1,TRAPPC3,STAMBP,DYNC1I2,UCHL3,MDM2,RAB19,VCPKMT,TGFBR2,LY6G6C,UBA52,PIAS1,EP300,OTUD7B,RAB4A,RNF103,PIGA,RAB3D,INO80C,JOSD1,SEC22C,H2AC7,CD52,PCNA,CCNA2,NEU1,NUP35,RAB37,PSMD6,GFPT1,MITF,UBE2D1,TNKS2,MPDU1,DPAGT1,PSMB10,PSMC5,UBE2W,SMAD2,POLB,TNKS,OS9,PSMB7,PSMD3,UAP1,MIR7-1,PSMB5,PSMA3,MBD5,ST3GAL1,TRAPPC4,SYVN1,COG1,B4GALT6,GALNT1,ALPL,YKT6,IFIH1,USP15,PSMD7,TMED3,RAB11A,ALG11,SUMO1,PSMB2,NUP42,FOLR2,DOHH,PSMC1,SNX3,FOLR1,GPAA1,MVD,PSMD4,LARGE1,RAB32,GMPPA,RAB33B,RPN1,SLC35A1,H2AC4,KDELR1,B3GNT2,NUP62,PTEN,ARCN1,SPTAN1,HNRNPC,SENP8,TAB1,BIRC5,PROS1,ACTB,RAD21,TMED7,F2,RAB14,GANAB,ST3GAL5,PSMD10,MIA2,PML,CHST10,SKIC8,TMED9,COPZ2,CDC73,ARFGAP3,RRAGA,TRAPPC1,RNF152,CFTR,TNFAIP3,PSMD12,FPGT,RAB30,USP2,DYNLL1,EDEM3,ALG2,TRAF6,EDEM1,NANP,PSMB9,SEC22A,B4GAT1,DAG1,LY6H,CEACAM5,PSMB11,DCTN3,KIN,DAD1,H2BC11,VDAC2,NUP50,BAP1,RAB1A,ADRB2,RAB1B,MGAT1,ST6GAL1,NAPA,FN3KRP,TRAPPC2L,RPS2,NTNG2,UBE2L3,UBE2G2,TOP2B,UBB,GALNT12,RAB9A,PSME1,FKBP8,USP8,H2BC12
R-HSA-69002	DNA Replication Pre-Initiation	2.21025033869085e-06	-13.0224047734241	86	48	0.0148652833694642	3229	10285	6233,5558,5710,4172,5702,5682,5698,7979,23594,6119,5721,9861,5692,5690,5707,5687,8317,56655,5718,23649,5700,84515,7311,7314,10213,51053,54107,5713,5716,5720,4175,5683,5694,6118,5691,5685,4173,122706,5705,5686,5699,5693,5684,5001,5704,5709,5695,5689	RPS27A,PRIM2,PSMD4,MCM3,PSMC3,PSMA1,PSMB9,SEM1,ORC6,RPA3,PSME2,PSMD6,PSMB4,PSMB2,PSMD1,PSMA6,CDC7,POLE4,PSMD12,POLA2,PSMC1,MCM8,UBA52,UBB,PSMD14,GMNN,POLE3,PSMD7,PSMD10,PSME1,MCM6,PSMA2,PSMB6,RPA2,PSMB3,PSMA4,MCM4,PSMB11,PSMC5,PSMA5,PSMB10,PSMB5,PSMA3,ORC5,PSMC4,PSMD3,PSMB7,PSMB1
R-HSA-68874	M/G1 Transition	2.21025033869085e-06	-13.0224047734241	86	48	0.0148652833694642	3229	10285	8317,5687,5690,5707,84515,23649,5700,5718,56655,5682,5702,5710,4172,5558,6233,5692,9861,5721,6119,23594,7979,5698,5699,5686,5705,122706,4173,5685,5691,6118,5694,4175,5683,5689,5695,5709,5001,5704,5693,5684,54107,51053,10213,7314,7311,5720,5716,5713	CDC7,PSMA6,PSMB2,PSMD1,MCM8,POLA2,PSMC1,PSMD12,POLE4,PSMA1,PSMC3,PSMD4,MCM3,PRIM2,RPS27A,PSMB4,PSMD6,PSME2,RPA3,ORC6,SEM1,PSMB9,PSMB10,PSMA5,PSMC5,PSMB11,MCM4,PSMA4,PSMB3,RPA2,PSMB6,MCM6,PSMA2,PSMB1,PSMB7,PSMD3,ORC5,PSMC4,PSMB5,PSMA3,POLE3,GMNN,PSMD14,UBB,UBA52,PSME1,PSMD10,PSMD7
R-HSA-202424	Downstream TCR signaling	2.4503685841205e-06	-12.9192721022248	98	53	0.0164137503871168	3229	10285	5588,10213,7314,7311,5720,6500,5716,4792,5713,5699,5686,5728,5705,122706,5685,4790,919,5691,5683,23291,5694,5689,5295,917,5695,5296,5709,5704,5693,5684,5682,5702,5710,6233,5692,7189,9861,5721,7321,3551,7979,5698,7335,5687,5290,5707,5690,920,23118,8915,5700,7334,5718	PRKCQ,PSMD14,UBB,UBA52,PSME1,SKP1,PSMD10,NFKBIA,PSMD7,PSMB10,PSMA5,PTEN,PSMC5,PSMB11,PSMA4,NFKB1,CD247,PSMB3,PSMA2,FBXW11,PSMB6,PSMB1,PIK3R1,CD3G,PSMB7,PIK3R2,PSMD3,PSMC4,PSMB5,PSMA3,PSMA1,PSMC3,PSMD4,RPS27A,PSMB4,TRAF6,PSMD6,PSME2,UBE2D1,IKBKB,SEM1,PSMB9,UBE2V1,PSMA6,PIK3CA,PSMD1,PSMB2,CD4,TAB2,BCL10,PSMC1,UBE2N,PSMD12
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	2.47915895837889e-06	-12.9075911849908	77	44	0.0136265097553422	3229	10285	5685,2056,5699,112398,5686,122706,5705,5694,5683,5691,5695,5709,5689,5684,5693,5704,10213,6921,7311,7314,5716,8453,5720,5713,2033,5690,5707,5687,5700,5718,1387,5702,7323,5682,6233,5710,112399,5721,7321,5692,9861,7979,5698,7422	PSMA4,EPO,PSMB10,EGLN2,PSMA5,PSMB11,PSMC5,PSMB6,PSMA2,PSMB3,PSMB7,PSMD3,PSMB1,PSMA3,PSMB5,PSMC4,PSMD14,ELOC,UBA52,UBB,PSMD10,CUL2,PSME1,PSMD7,EP300,PSMB2,PSMD1,PSMA6,PSMC1,PSMD12,CREBBP,PSMC3,UBE2D3,PSMA1,RPS27A,PSMD4,EGLN3,PSME2,UBE2D1,PSMB4,PSMD6,SEM1,PSMB9,VEGFA
R-HSA-2262749	Cellular response to hypoxia	2.47915895837889e-06	-12.9075911849908	77	44	0.0136265097553422	3229	10285	5691,5694,5683,5686,5699,112398,122706,5705,5685,2056,5704,5684,5693,5689,5695,5709,7314,7311,6921,10213,2033,5713,5720,5716,8453,5687,5690,5707,5700,5718,1387,5710,6233,5682,7323,5702,7422,7979,5698,5692,9861,112399,5721,7321	PSMB3,PSMB6,PSMA2,PSMA5,PSMB10,EGLN2,PSMB11,PSMC5,PSMA4,EPO,PSMC4,PSMA3,PSMB5,PSMB1,PSMB7,PSMD3,UBB,UBA52,ELOC,PSMD14,EP300,PSMD7,PSME1,PSMD10,CUL2,PSMA6,PSMB2,PSMD1,PSMC1,PSMD12,CREBBP,PSMD4,RPS27A,PSMA1,UBE2D3,PSMC3,VEGFA,SEM1,PSMB9,PSMB4,PSMD6,EGLN3,PSME2,UBE2D1
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	2.54392016876903e-06	-12.8818042931796	91	50	0.0154846701765252	3229	10285	122706,5705,5686,5699,5685,3184,11340,8125,5691,26986,5694,5683,5689,54512,5709,5695,5704,5693,5684,7529,10213,7314,7311,5578,3312,5720,5716,51013,7534,5713,167227,3315,207,7514,5687,5707,5690,5718,5700,8741,5682,5702,5710,6233,9861,5692,5721,51010,5698,7979	PSMB11,PSMC5,PSMA5,PSMB10,PSMA4,HNRNPD,EXOSC8,ANP32A,PSMB3,PABPC1,PSMB6,PSMA2,PSMB1,EXOSC4,PSMD3,PSMB7,PSMC4,PSMB5,PSMA3,YWHAB,PSMD14,UBB,UBA52,PRKCA,HSPA8,PSME1,PSMD10,EXOSC1,YWHAZ,PSMD7,DCP2,HSPB1,AKT1,XPO1,PSMA6,PSMD1,PSMB2,PSMD12,PSMC1,TNFSF13,PSMA1,PSMC3,PSMD4,RPS27A,PSMD6,PSMB4,PSME2,EXOSC3,PSMB9,SEM1
R-HSA-397795	G-protein beta:gamma signalling	3.80065873019861e-06	-12.4803361562031	51	32	0.00991018891297615	3229	10285	3562,2782,2788,59345,54331,55970,3559,6464,10000,2785,5294,207,5290,5330,51764,3558,2790,208,23236,2791,3567,2787,3716,8503,3560,2793,2784,5295,1437,5296,3561,3717	IL3,GNB1,GNG7,GNB4,GNG2,GNG12,IL2RA,SHC1,AKT3,GNG3,PIK3CG,AKT1,PIK3CA,PLCB2,GNG13,IL2,GNG10,AKT2,PLCB1,GNG11,IL5,GNG5,JAK1,PIK3R3,IL2RB,GNGT2,GNB3,PIK3R1,CSF2,PIK3R2,IL2RG,JAK2
R-HSA-72649	Translation initiation complex formation	3.82233264507257e-06	-12.4746496816392	62	37	0.0114586559306287	3229	10285	7458,6233,6203,6207,1965,6235,6205,6228,6187,6206,6191,6218,6204,6234,1964,51065,6231,6201,6193,6209,1977,6208,27335,26986,8666,6188,8894,3646,1975,2197,1974,6229,8664,6217,8669,6224,3921	EIF4H,RPS27A,RPS9,RPS13,EIF2S1,RPS29,RPS11,RPS23,RPS2,RPS12,RPS4X,RPS17,RPS10,RPS28,EIF1AX,RPS27L,RPS26,RPS7,RPS5,RPS15,EIF4E,RPS14,EIF3K,PABPC1,EIF3G,RPS3,EIF2S2,EIF3E,EIF4B,FAU,EIF4A2,RPS24,EIF3D,RPS16,EIF3J,RPS20,RPSA
R-HSA-446203	Asparagine N-linked glycosylation	4.02781288147099e-06	-12.4222870386381	284	125	0.0387116754413131	3229	10285	29926,10484,6184,3972,9554,2683,10559,10945,9570,10113,4597,3998,3703,79090,122553,7991,6233,55738,79139,7903,2348,6484,2923,5700,378,1780,29880,440138,966,55343,6483,7109,29906,8702,64841,8869,10175,4253,9486,51014,79644,6396,7311,55907,11316,23193,11070,27095,375,22845,1781,2530,2890,2762,51128,51164,6709,23256,372,2673,51272,9695,10671,11320,10342,26984,140838,1798,9526,8655,80267,85365,4758,8818,11282,5887,5476,58485,9117,811,8790,7844,51226,116150,54732,55741,26286,10652,6711,9527,23423,10905,256435,51693,8703,10282,6048,51009,7264,6482,7314,84447,9382,51399,6811,5373,5265,9331,81876,10956,5861,11236,6675,6480,11014,55014,4245,8775,100313843,11258,29925,8774,1603,26503,1075	GMPPA,SEC23A,RPN1,LHB,SEC22B,B4GALT1,SLC35A1,KDELR1,GOSR2,PREB,MVD,LMAN1,STT3A,TRAPPC6A,TRAPPC6B,TUSC3,RPS27A,ARFGAP1,DERL1,ST8SIA4,FOLR1,ST3GAL4,PDIA3,PSMC1,ARF4,DYNC1I1,ALG5,ALG11,CD59,SLC35C1,ST3GAL2,TRAPPC10,ST8SIA5,B4GALT4,GNPNAT1,ST3GAL5,CNIH1,MIA2,CHST10,TMED7,SRD5A3,SEC13,UBA52,CMAS,COPE,GANAB,TMEM115,TRAPPC3,ARF1,DOLK,DYNC1I2,FUT8,GRIA1,GMDS,SAR1B,DCTN4,SPTAN1,SCFD1,ARCN1,GFPT1,BET1L,EDEM1,DCTN6,MGAT4A,TFG,SEC22A,NANP,DPAGT1,MPDU1,DYNLL1,EDEM3,ALG2,NEU1,DPM2,MGAT4B,RAD23B,CTSA,TRAPPC1,SEC22C,CALR,FPGT,RNF103,COPZ2,NUS1,TMED9,EDEM2,ARFGAP3,YKT6,SPTBN1,GOSR1,TMED3,MAN1A2,ST6GALNAC3,TRAPPC2L,B4GALT3,BET1,RNF5,DERL2,GFUS,ST3GAL1,UBB,SYVN1,COG1,TRAPPC4,STX5,PMM2,SERPINA1,B4GALT6,RAB1B,OS9,RAB1A,RNF139,UAP1,ST6GAL1,KDELR2,STX17,MGAT1,NAPA,MIR711,DCTN3,GMPPB,NAPG,DAD1,SLC17A5,CTSC
R-HSA-1280218	Adaptive Immune System	4.43997938292671e-06	-12.3248608250159	810	312	0.0966243419015175	3229	10285	5579,2209,811,5718,3385,208,3383,10193,2248,2213,7189,55658,5698,26118,55294,572,2931,9402,8655,10870,29126,9040,144699,93611,29116,8773,8881,84676,10768,5689,917,991,975,5704,5685,11258,3824,5133,23643,122706,2260,10952,10477,5694,5683,80196,7704,140461,8453,7320,5720,4690,947,11027,84231,10213,7332,25831,7327,6478,5781,958,140739,11006,5518,3937,7314,8915,23118,1509,1780,120425,5700,8452,10120,5516,57154,3265,3796,7335,6892,5690,5707,5290,207,25780,6464,3551,7097,23480,8697,1513,5062,9554,1493,8905,5682,84861,3685,5710,79791,6737,5296,55070,9870,9021,7220,2246,6402,340205,10075,4233,4790,27246,6477,6468,5728,7328,8394,25847,26249,3797,4345,5716,10859,948,10616,54620,4343,7096,974,79654,3845,6786,8673,27006,6850,51665,5894,57690,4793,5476,920,8916,1026,8503,3384,2252,114609,374383,1175,11059,7336,29127,55958,26263,26091,1173,5906,10273,10671,5721,7321,8778,1839,9861,29882,55521,26191,51343,4615,11024,64837,89890,51132,9616,23376,221687,5695,114907,1385,5709,11026,911,5295,22954,9976,5693,5684,1027,55284,1785,567,5699,5705,7305,7337,55176,3702,23291,1075,1445,940,23194,26523,9039,6500,959,140456,80228,8822,941,5819,5713,910,81559,7319,6921,5567,7099,246184,867,80380,8907,9020,8823,255488,84085,80176,51130,8870,7334,29927,2923,26235,9371,899,909,3815,2549,79837,9604,84937,912,8174,3093,10000,5687,25793,3693,10484,5692,929,7979,10121,29945,5702,7157,7323,942,10385,6233,3309,51529,7325,375,29851,7529,998,4193,1781,5525,10333,64410,51128,5686,8074,5529,51348,4068,160,7525,259197,919,140460,5691,51164,26224,4277,4591,25898,6714,26268,390594,118788,9341,2255,131450,4792,7534,5908,5588,8764,6396,27338,1508,30835,7311,10666,10235,10533,4360	PRKCB,FCGR1A,CALR,PSMD12,ICAM3,AKT2,ICAM1,RNF41,FGF3,FCGR2B,TRAF6,RNF126,PSMB9,WSB1,FBXW7,BAD,GSK3A,GRAP2,DYNLL1,HCST,CD274,UBE2M,FBXL14,FBXO44,MYLIP,SNAP23,CDC16,TRIM63,AHCYL1,PSMB1,CD3G,CDC20,CD81,PSMC4,PSMA4,DCTN3,KLRD1,PDCD1,LY96,PSMB11,FGFR1,SEC61B,UBE2E3,PSMB6,PSMA2,RNF34,ZBTB16,ASB8,CUL2,UBE2B,PSME1,NCK1,CD34,LILRA2,TRAF7,PSMD14,UBE2L3,HECTD1,UBE2G2,SIAH2,PTPN11,CD40,UBE2F,LILRB4,PPP2R1A,LCP2,UBB,BCL10,TAB2,CTSD,DYNC1I1,JAML,PSMC1,CUL3,ACTR1B,PPP2CB,SMURF1,HRAS,KIF2A,UBE2V1,TAPBP,PSMB2,PSMD1,PIK3CA,AKT1,RASGRP3,SHC1,IKBKB,TLR2,SEC61G,CDC23,CTSK,PAK2,SEC22B,CTLA4,AP1S2,PSMA1,KLHL22,ITGAV,PSMD4,FBXO31,TRIM21,PIK3R2,DET1,AREL1,SOCS3,TRPC1,FGF1,SELL,TREML1,HUWE1,MET,NFKB1,RNF115,SIAH1,FBXW4,PTEN,UBE2H,PIP5K1A,ANAPC13,KLHL3,KIF3C,CD200,PSMD10,LILRB1,CD36,RBCK1,FBXL19,MOV10,TLR1,CD79B,HECTD3,KRAS,STIM1,VAMP8,FGF22,SYK,ASB1,RAF1,TNRC6C,NFKBIB,CTSA,CD4,HERC3,CDKN1A,PIK3R3,ICAM2,FGF7,TIRAP,NCR3LG1,AP2S1,WWP1,UBE2V2,RACGAP1,KLHL9,FBXO22,HERC4,AP2M1,RAP1A,STUB1,DCTN6,PSME2,UBE2D1,SIGLEC5,HBEGF,PSMD6,ANAPC2,TRIM36,PTPN22,FZR1,MYD88,LILRA1,KLC2,KBTBD6,RLIM,RNF7,UFL1,RNF182,PSMB7,FBXO32,CREB1,PSMD3,LILRA3,CD1C,PIK3R1,TRIM32,CLEC2B,PSMB5,PSMA3,CDKN1B,UBE2W,DNM2,B2M,PSMB10,PSMC5,TYROBP,UBE3A,SEC61A2,ITK,FBXW11,CTSC,CSK,CD28,FBXL7,AGO1,UBA3,SKP1,CD40LG,ASB11,ORAI2,FGF17,CD80,NECTIN2,PSMD7,CD1B,TRIM11,UBE2A,ELOC,PRKACB,TLR4,CDC26,CBL,PDCD1LG2,AP1M1,MAP3K14,FGF16,RNF144B,FBXO30,SPSB1,ASB3,IER3,UBE2N,SEC61A1,PDIA3,FBXL4,KIF3B,CCNF,CD1A,KIT,GAB1,PIP4K2C,RNF14,ZNRF1,CD1D,MADCAM1,UBE2K,AKT3,PSMA6,FBXO7,ITGB5,SEC23A,PSMB4,CD14,SEM1,ACTR1A,ANAPC4,PSMC3,TP53,UBE2D3,CD86,BTN2A2,RPS27A,HSPA5,ANAPC11,UBE2E2,ARF1,ICOS,YWHAB,CDC42,MDM2,DYNC1I2,PPP2R5A,TLR6,KLHL25,SAR1B,PSMA5,FGF23,PPP2R5E,KLRF1,SH2D1A,AP2A1,YES1,NCR3,CD247,ASB7,PSMB3,DCTN4,FBXL3,MICB,TRIM37,RCHY1,SRC,FBXO9,KBTBD13,PIK3AP1,VAMP3,FGF10,CD200R1,NFKBIA,YWHAZ,RAP1B,PRKCQ,TNFRSF14,SEC13,UBE2S,CTSB,CD209,UBA52,CD226,RASGRP2,ATG7,MRC1
R-HSA-5689603	UCH proteinases	5.82943533086815e-06	-12.0525904180615	105	55	0.0170331371941778	3229	10285	5695,5709,5689,86,8314,221613,5693,5684,60,5704,123228,7347,5685,5699,5686,122706,5705,5694,5683,92815,5691,9958,5716,5720,5713,283899,10213,55777,7311,7048,7314,3013,8607,5700,5718,4738,8329,11047,5707,5690,125476,5687,5721,5692,9861,7979,5698,8335,8331,5702,5682,8334,6233,29844,5710	PSMB7,PSMD3,PSMB1,ACTL6A,BAP1,H2AC1,PSMB5,PSMA3,ACTB,PSMC4,SENP8,UCHL3,PSMA4,PSMB10,PSMA5,PSMB11,PSMC5,PSMB6,PSMA2,H2AC25,PSMB3,USP15,PSMD10,PSME1,PSMD7,INO80E,PSMD14,MBD5,UBA52,TGFBR2,UBB,H2AC7,RUVBL1,PSMC1,PSMD12,NEDD8,H2AC13,ADRM1,PSMD1,PSMB2,INO80C,PSMA6,PSME2,PSMB4,PSMD6,SEM1,PSMB9,H2AC4,H2AC14,PSMC3,PSMA1,H2AC6,RPS27A,TFPT,PSMD4
R-HSA-69620	Cell Cycle Checkpoints	5.93649628406193e-06	-12.0343914497884	201	93	0.0288014865283369	3229	10285	10213,246184,7314,5720,983,5713,85236,8348,4173,5685,5699,5705,2810,122706,9184,5694,4175,5683,9025,8970,6118,5695,8881,5709,5689,991,80010,5693,5684,5001,5704,1027,255626,8345,5984,890,5721,7321,6119,25906,5985,9861,29882,5698,5983,7532,7336,3014,1026,119504,891,5718,9656,7311,57060,7533,5716,7534,5686,116028,5691,8342,5982,7529,4193,7157,5702,5682,6233,51529,5710,5932,4172,5810,23594,5692,8697,672,7979,4683,29945,8317,5707,5690,5687,7341,4085,84515,11073,29086,5700,64326,7334	PSMD14,CDC26,UBB,PSME1,CDK1,PSMD7,H2BC12,H2BC17,MCM4,PSMA4,PSMB10,PSMC5,SFN,PSMB11,BUB3,PSMB6,MCM6,PSMA2,RNF8,H2BC11,RPA2,PSMB7,CDC16,PSMD3,PSMB1,CDC20,RMI1,PSMB5,PSMA3,ORC5,PSMC4,CDKN1B,H2BC1,H2BC9,RFC4,CCNA2,PSME2,UBE2D1,RPA3,ANAPC15,RFC5,PSMD6,ANAPC2,PSMB9,RFC3,YWHAG,UBE2V2,H2AX,CDKN1A,ANAPC16,CCNB1,PSMD12,MDC1,UBA52,PCBP4,YWHAH,PSMD10,YWHAZ,PSMA5,RMI2,PSMB3,H2BC14,RFC2,YWHAB,MDM2,TP53,PSMC3,PSMA1,RPS27A,ANAPC11,PSMD4,RBBP8,MCM3,RAD1,ORC6,PSMB4,CDC23,BRCA1,SEM1,NBN,ANAPC4,CDC7,PSMD1,PSMB2,PSMA6,SUMO1,MAD2L1,MCM8,TOPBP1,BABAM1,PSMC1,COP1,UBE2N
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	6.47451912745722e-06	-11.9476362191663	63	37	0.0114586559306287	3229	10285	3921,8669,6224,6217,8664,1974,6229,2197,3646,1975,8894,6188,8666,27335,26986,6208,1977,6209,6193,51065,6201,6231,6234,1964,6204,6218,6191,6206,6187,6228,6235,6205,1965,6207,6233,6203,7458	RPSA,EIF3J,RPS20,RPS16,EIF3D,EIF4A2,RPS24,FAU,EIF3E,EIF4B,EIF2S2,RPS3,EIF3G,EIF3K,PABPC1,RPS14,EIF4E,RPS15,RPS5,RPS27L,RPS7,RPS26,RPS28,EIF1AX,RPS10,RPS17,RPS4X,RPS12,RPS2,RPS23,RPS29,RPS11,EIF2S1,RPS13,RPS27A,RPS9,EIF4H
R-HSA-1280215	Cytokine Signaling in Immune system	7.11448648452149e-06	-11.8533775026713	756	292	0.0904304738309074	3229	10285	356,60401,5686,3440,8074,1977,5529,7525,5691,5037,3447,3458,7529,6804,6352,53840,5525,5908,6773,8764,3586,84292,10612,7311,1271,317649,3574,10817,1852,3836,6714,8554,2255,9966,7534,3567,28956,3815,81603,3601,146433,5687,4170,6041,9020,8823,818,3592,3560,3446,7450,7334,3664,80128,7157,5702,3454,54472,7186,942,1442,6233,1958,3556,54739,5770,161742,117854,5692,3429,7979,23586,7422,1843,10379,5699,567,4692,5705,3558,23291,58480,50616,8315,1445,1742,3636,5695,3430,25939,5709,8350,6363,55223,5295,5693,5684,2353,2919,3660,7076,7850,23087,10068,3312,9655,867,3576,5536,6500,959,9039,3593,2690,941,8822,55128,5713,4599,5495,6772,57122,5906,9775,920,8503,1026,2252,3838,4050,4609,23650,10538,1974,10346,4502,129401,4747,11221,8878,5721,1839,85363,9861,7184,200734,10107,4215,3456,4615,51135,4055,152559,4790,4233,3726,3552,6709,2537,3600,3561,5296,4938,6737,4600,9021,10454,332,9636,1154,2688,2246,8742,1848,3845,5604,80263,27006,6850,51561,246330,5894,6348,5716,3659,948,3596,595,4318,5371,604,729230,6778,3265,3433,5516,3665,7335,11097,5690,5707,207,8682,7341,3320,5290,53833,3606,23118,3669,8649,5608,1234,8452,5700,5682,8741,5008,3562,3459,5710,5245,4988,8835,3551,25780,6464,598,23636,6356,5685,6364,2260,122706,5694,112744,5683,3565,3717,7133,5689,10762,1399,6347,3569,6657,1230,5704,3662,10213,5781,958,91543,5518,57162,7124,6776,7314,4049,5896,6711,284,5720,5617,3383,3394,53358,3604,3572,8995,79023,5610,1437,2209,3716,944,3661,684,5718,1278,4296,3553,9470,9040,329,3627,2248,7189,3559,9972,5698,7726	FASLG,EDA2R,PSMA5,IFNA2,FGF23,EIF4E,PPP2R5E,YES1,PSMB3,PEBP1,IFNA13,IFNG,YWHAB,STX1A,CCL5,TRIM34,PPP2R5A,RAP1B,STAT2,TNFRSF14,IL10,WDR83,TRIM3,UBA52,CNTFR,EIF4E3,IL7,FRS3,DUSP9,KPNA1,SRC,PIAS1,FGF10,TNFSF15,YWHAZ,IL5,LAMTOR2,KIT,TRIM8,IL15RA,IL34,PSMA6,MCL1,RNASEL,MAP3K14,FGF16,CAMK2G,IL12A,IL2RB,IFNA10,VWF,UBE2N,IRF6,TRIM46,TP53,PSMC3,IFNAR1,TOLLIP,TRAF2,CD86,CSH1,RPS27A,EGR1,IL1RAP,XAF1,PTPN1,SPRED1,TRIM6,PSMB4,IFI27,SEM1,RIGI,VEGFA,DUSP1,IRF9,PSMB10,B2M,NDN,PSMC5,IL2,FBXW11,RHOU,IL22,BRAP,CSK,DLG4,INPPL1,PSMB7,IFI35,SAMHD1,PSMD3,H3C1,CCL19,TRIM62,PIK3R1,PSMB5,PSMA3,FOS,CXCL1,IRF2,TIMP1,IL1R2,TRIM35,IL18BP,HSPA8,SOCS5,CBL,CXCL8,PPP5C,SKP1,CD40LG,UBA3,IL12B,GHR,CD80,FGF17,TRIM68,PSMD7,MX1,PPM1B,STAT1,NUP107,RAP1A,EIF4A3,CD4,PIK3R3,CDKN1A,FGF7,KPNA2,LTB,MYC,TRIM29,BATF,EIF4A2,TRIM22,MT2A,NUP35,NEFL,DUSP10,SQSTM1,PSME2,HBEGF,TRIM5,PSMD6,HSP90B1,SPRED2,TRIM10,MAP3K3,IFNB1,MYD88,IRAK4,LTBR,PAQR3,NFKB1,MET,JUNB,IL1A,SPTAN1,IFI6,IL15,IL2RG,PIK3R2,OAS1,TRIM21,MX2,SOCS3,TAB1,BIRC5,ISG15,CISH,GH1,FGF1,TNFSF12,DUSP6,KRAS,MAP2K1,TRIM45,FGF22,SYK,IL23A,PELI3,RAF1,CCL3,PSMD10,IRF1,CD36,IL13,CCND1,MMP9,PML,BCL6,CCR2,STAT6,HRAS,IFIT2,PPP2CB,IRF7,UBE2V1,NUP42,PSMB2,PSMD1,AKT1,PEA15,SUMO1,HSP90AA1,PIK3CA,IL20RB,IL18,TAB2,ISG20,LAMTOR3,MAP2K6,CCR5,CUL3,PSMC1,PSMA1,TNFSF13,OSM,IL3,IFNGR1,PSMD4,PHB1,OPRM1,SOCS2,IKBKB,RASGRP3,SHC1,BCL2L1,NUP62,CCL11,PSMA4,CCL20,FGFR1,PSMB11,PSMB6,IL17F,PSMA2,IL4,JAK2,TNFRSF1B,PSMB1,NUP50,CRKL,CCL2,IL6,SOX2,CCR1,PSMC4,IRF4,PSMD14,PTPN11,CD40,RSAD2,PPP2R1A,PELI1,TNF,STAT5A,UBB,LTA,RAG1,SPTBN1,ANGPT1,PSME1,PRL,ICAM1,IRF8,SHC3,TNFRSF9,IL6ST,TNFSF18,NUP37,EIF2AK2,CSF2,FCGR1A,JAK1,TNFSF8,IRF3,BST2,PSMD12,COL1A2,MAP3K11,IL1B,EIF4E2,UBE2M,BIRC2,CXCL10,FGF3,TRAF6,IL2RA,NUP153,PSMB9,TRIM26
R-HSA-72702	Ribosomal scanning and start codon recognition	7.38327675974679e-06	-11.8162930125074	61	36	0.0111489625270982	3229	10285	8666,6188,8894,3646,1975,6208,1977,27335,8669,6224,3921,2197,6229,8664,1974,6217,6205,6235,1965,6228,6187,6206,6191,7458,6233,6203,6207,6193,6209,6218,6234,6204,1964,51065,6201,6231	EIF3G,RPS3,EIF2S2,EIF3E,EIF4B,RPS14,EIF4E,EIF3K,EIF3J,RPS20,RPSA,FAU,RPS24,EIF3D,EIF4A2,RPS16,RPS11,RPS29,EIF2S1,RPS23,RPS2,RPS12,RPS4X,EIF4H,RPS27A,RPS9,RPS13,RPS5,RPS15,RPS17,RPS28,RPS10,EIF1AX,RPS27L,RPS7,RPS26
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	7.40856195845058e-06	-11.8128742051753	158	76	0.0235366986683184	3229	10285	91942,5160,50,513,9377,498,1327,92483,51204,4729,4698,514,506,4710,4726,84987,2739,4712,55863,10476,9481,7384,1340,4697,8801,3419,2109,10975,4718,27089,51241,539,1737,515,10632,6391,5162,3420,7385,116228,25915,4720,4716,1537,1351,4713,9016,1353,2108,516,7388,3418,4714,522,4711,137682,4695,1743,1349,57546,29078,80219,7351,3939,3945,51660,4728,55967,4706,518,1345,6390,4694,4722,51300,6566	NDUFAF2,PDHA1,ACO2,ATP5F1D,COX5A,ATP5F1A,COX4I1,LDHAL6B,TACO1,NDUFV2,NDUFA5,ATP5F1E,ATP5F1B,NDUFB4,NDUFS6,COX14,GLO1,NDUFB6,TMEM126B,ATP5PD,SLC25A27,UQCRC1,COX6B1,NDUFA4,SUCLG2,IDH3A,ETFB,UQCR11,NDUFC2,UQCRQ,COX16,ATP5PO,DLAT,ATP5PB,ATP5MG,SDHC,PDHB,IDH3B,UQCRC2,COX20,NDUFAF3,NDUFS2,NDUFB10,CYC1,COX8A,NDUFB7,SLC25A14,COX11,ETFA,ATP5MC1,UQCRH,IDH2,NDUFB8,ATP5PF,NDUFB5,NDUFAF6,NDUFA2,DLST,COX7B,PDP2,NDUFAF4,COQ10B,UCP2,LDHA,LDHB,MPC1,NDUFS8,NDUFA12,NDUFAB1,ATP5MC3,COX6C,SDHB,NDUFA1,NDUFS3,TIMMDC1,SLC16A1
R-HSA-5689880	Ub-specific processing proteases	7.65349934890108e-06	-11.7803475834867	223	101	0.031279033756581	3229	10285	11047,8329,5687,8678,79594,5707,5690,8975,84749,8724,5700,4089,8334,5682,7186,9960,7157,5702,367,5710,81847,6233,5692,8078,7353,8335,7979,23586,5686,5728,9097,27430,9868,5691,92815,8342,9986,10454,221613,4193,4088,6881,7311,5716,4792,3416,7416,4086,51651,10474,3013,1080,10600,5718,8607,9099,4609,255626,8331,9804,890,8345,91833,79589,7189,9861,5721,329,80351,9146,5698,5699,5705,122706,4087,8348,5685,5423,8970,8658,7417,5683,5694,5689,154,991,5695,5709,5704,5684,5693,6478,10213,7314,5720,23770,64135,9958,9101,5713,85236	ADRM1,H2AC13,PSMA6,BECN1,MUL1,PSMD1,PSMB2,USP13,USP30,SNX3,PSMC1,SMAD4,H2AC6,PSMA1,TRAF2,USP3,TP53,PSMC3,AR,PSMD4,RNF146,RPS27A,PSMB4,USP5,UFD1,H2AC4,SEM1,RIGI,PSMA5,PTEN,USP14,MAT2B,TOMM70,PSMB3,H2AC25,H2BC14,RCE1,TAB1,H2AC1,MDM2,SMAD3,TAF10,UBA52,PSMD10,NFKBIA,IDE,VDAC1,SMAD1,PTRH2,TADA3,H2AC7,CFTR,USP16,PSMD12,RUVBL1,USP2,MYC,H2BC1,H2AC14,TOMM20,CCNA2,H2BC9,WDR20,RNF128,TRAF6,PSMD6,PSME2,BIRC2,TNKS2,HGS,PSMB9,PSMB10,PSMC5,PSMB11,SMAD2,H2BC17,PSMA4,POLB,H2BC11,TNKS,VDAC2,PSMA2,PSMB6,PSMB1,ADRB2,CDC20,PSMB7,PSMD3,PSMC4,PSMA3,PSMB5,SIAH2,PSMD14,UBB,PSME1,FKBP8,IFIH1,USP15,USP8,PSMD7,H2BC12
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	8.00425508829553e-06	-11.7355372716487	18	15	0.00464540105295757	3229	10285	29110,929,3661,7098,353376,7314,23098,6233,10010,7311,7099,23643,3665,5781,148022	TBK1,CD14,IRF3,TLR3,TICAM2,UBB,SARM1,RPS27A,TANK,UBA52,TLR4,LY96,IRF7,PTPN11,TICAM1
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	8.56078127187944e-06	-11.6683191018961	48	30	0.00929080210591514	3229	10285	2788,59345,3562,2782,6464,55970,3559,54331,3567,2787,2791,2790,3558,208,51764,5294,10000,207,2785,5290,3717,3561,5296,1437,8503,2793,3560,5295,2784,3716	GNG7,GNB4,IL3,GNB1,SHC1,GNG12,IL2RA,GNG2,IL5,GNG5,GNG11,GNG10,IL2,AKT2,GNG13,PIK3CG,AKT3,AKT1,GNG3,PIK3CA,JAK2,IL2RG,PIK3R2,CSF2,PIK3R3,GNGT2,IL2RB,PIK3R1,GNB3,JAK1
R-HSA-109581	Apoptosis	1.03364827861372e-05	-11.4798309028298	172	81	0.0250851656859709	3229	10285	6709,51765,5683,5694,5691,5366,356,5685,2810,122706,5705,23643,5699,5686,5684,5693,3024,7529,5704,5709,5695,5689,6304,7099,4000,7311,7533,7314,10213,5588,3007,581,7534,5713,1613,6093,5716,1676,3836,5720,578,5690,5707,8428,5687,207,10000,7532,148022,208,118,5718,5700,1612,7098,6233,4001,5710,7029,5702,355,7157,1499,572,7186,5682,8655,5698,7979,598,2620,929,3009,353376,329,8743,5721,9861,3146,5062,5692	SPTAN1,STK26,PSMA2,PSMB6,PSMB3,PMAIP1,FASLG,PSMA4,SFN,PSMB11,PSMC5,LY96,PSMB10,PSMA5,PSMA3,PSMB5,H1-1,YWHAB,PSMC4,PSMD3,PSMB7,PSMB1,SATB1,TLR4,LMNA,UBA52,YWHAH,UBB,PSMD14,PRKCQ,H1-3,BAX,YWHAZ,PSMD7,DAPK3,ROCK1,PSMD10,DFFA,KPNA1,PSME1,BAK1,PSMB2,PSMD1,STK24,PSMA6,AKT1,AKT3,YWHAG,TICAM1,AKT2,ADD1,PSMD12,PSMC1,DAPK1,TLR3,RPS27A,LMNB1,PSMD4,TFDP2,PSMC3,FAS,TP53,CTNNB1,BAD,TRAF2,PSMA1,DYNLL1,PSMB9,SEM1,BCL2L1,GAS2,CD14,H1-5,TICAM2,BIRC2,TNFSF10,PSME2,PSMD6,HMGB1,PAK2,PSMB4
R-HSA-202403	TCR signaling	1.08547214980296e-05	-11.4309104115242	119	60	0.0185816042118303	3229	10285	5707,5690,5290,5687,7335,5718,7334,5700,23118,8915,920,6233,5710,5702,9402,5682,26191,5698,7979,3551,5721,7321,9861,7189,5062,5692,5683,23291,3702,5694,5691,1445,919,4790,5685,122706,5705,5728,5699,5686,5693,5684,5704,5709,5296,5695,917,5295,5689,7311,3937,7314,10213,5588,4690,5713,4792,5716,6500,5720	PSMD1,PSMB2,PIK3CA,PSMA6,UBE2V1,PSMD12,UBE2N,PSMC1,TAB2,BCL10,CD4,RPS27A,PSMD4,PSMC3,GRAP2,PSMA1,PTPN22,PSMB9,SEM1,IKBKB,PSME2,UBE2D1,PSMD6,TRAF6,PAK2,PSMB4,PSMA2,FBXW11,ITK,PSMB6,PSMB3,CSK,CD247,NFKB1,PSMA4,PSMB11,PSMC5,PTEN,PSMB10,PSMA5,PSMB5,PSMA3,PSMC4,PSMD3,PIK3R2,PSMB7,CD3G,PIK3R1,PSMB1,UBA52,LCP2,UBB,PSMD14,PRKCQ,NCK1,PSMD7,NFKBIA,PSMD10,SKP1,PSME1
R-HSA-162909	Host Interactions of HIV factors	1.09596376108411e-05	-11.4212913416953	134	66	0.0204397646330133	3229	10285	9972,7979,5698,23636,5721,5692,9861,5062,6233,129401,5710,5702,8905,5682,292,5700,5718,79023,1025,920,5901,5690,5707,1173,11097,57122,5687,7514,1175,3159,5478,5713,5716,3836,5720,9844,6500,7311,8907,5902,7314,10213,6921,5684,5693,5704,5695,375,60489,5709,10762,5689,5683,160,5694,919,5691,940,5685,291,8815,567,5699,5686,122706,5705	NUP153,SEM1,PSMB9,NUP62,PSME2,PSMB4,PSMD6,PAK2,RPS27A,NUP35,PSMD4,PSMC3,AP1S2,PSMA1,SLC25A5,PSMC1,PSMD12,NUP37,CDK9,CD4,RAN,PSMB2,PSMD1,AP2M1,NUP42,NUP107,PSMA6,XPO1,AP2S1,HMGA1,PPIA,PSMD7,PSMD10,KPNA1,PSME1,ELMO1,SKP1,UBA52,AP1M1,RANBP1,UBB,PSMD14,ELOC,PSMA3,PSMB5,PSMC4,PSMB7,ARF1,APOBEC3G,PSMD3,NUP50,PSMB1,PSMA2,AP2A1,PSMB6,CD247,PSMB3,CD28,PSMA4,SLC25A4,BANF1,B2M,PSMB10,PSMA5,PSMB11,PSMC5
R-HSA-109688	Cleavage of Growing Transcript in the Termination Region	1.1279895315637e-05	-11.3924885924661	71	40	0.0123877361412202	3229	10285	100302196,23283,9984,10898,84967,25888,79228,4116,6429,10978,53981,9877,6427,6432,693221,22794,9785,6426,10189,51362,10212,9775,6637,6635,6628,84248,29894,7919,100126351,10914,22916,6634,10569,1479,84271,84321,55110,57187,26097,65109	MIR1234,CSTF2T,THOC1,CPSF4,LSM10,ZNF473,THOC6,MAGOH,SRSF4,CLP1,CPSF2,ZC3H11A,SRSF2,SRSF7,MIR636,CASC3,DHX38,SRSF1,ALYREF,CDC40,DDX39A,EIF4A3,SNRPG,SNRPE,SNRPB,FYTTD1,CPSF1,DDX39B,MIR939,PAPOLA,NCBP2,SNRPD3,SLU7,CSTF3,POLDIP3,THOC3,MAGOHB,THOC2,CHTOP,UPF3B
R-HSA-73856	RNA Polymerase II Transcription Termination	1.1279895315637e-05	-11.3924885924661	71	40	0.0123877361412202	3229	10285	22794,693221,9785,6432,6427,9775,10212,10189,6426,51362,25888,84967,4116,79228,9984,23283,100302196,10898,9877,6429,10978,53981,10569,84321,84271,1479,100126351,7919,6634,10914,22916,65109,55110,26097,57187,6637,29894,6635,84248,6628	CASC3,MIR636,DHX38,SRSF7,SRSF2,EIF4A3,DDX39A,ALYREF,SRSF1,CDC40,ZNF473,LSM10,MAGOH,THOC6,THOC1,CSTF2T,MIR1234,CPSF4,ZC3H11A,SRSF4,CLP1,CPSF2,SLU7,THOC3,POLDIP3,CSTF3,MIR939,DDX39B,SNRPD3,PAPOLA,NCBP2,UPF3B,MAGOHB,CHTOP,THOC2,SNRPG,CPSF1,SNRPE,FYTTD1,SNRPB
R-HSA-72165	mRNA Splicing - Minor Pathway	1.22233988272659e-05	-11.3121585064561	53	32	0.00991018891297615	3229	10285	6426,57819,6432,6427,83443,693221,5432,6632,2962,10262,5438,9416,5431,22916,6634,154007,5436,11325,6635,10907,2963,6628,5435,51639,23451,55954,6633,9410,6637,5433,5441,85437	SRSF1,LSM2,SRSF7,SRSF2,SF3B5,MIR636,POLR2C,SNRPD1,GTF2F1,SF3B4,POLR2I,DDX23,POLR2B,NCBP2,SNRPD3,SNRNP48,POLR2G,DDX42,SNRPE,TXNL4A,GTF2F2,SNRPB,POLR2F,SF3B6,SF3B1,ZMAT5,SNRPD2,SNRNP40,SNRPG,POLR2D,POLR2L,ZCRB1
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	1.22233988272659e-05	-11.3121585064561	53	32	0.00991018891297615	3229	10285	6193,6209,1964,6204,6234,6218,6231,51065,6201,6228,6235,1965,6205,6191,6206,6187,6233,6203,6207,8669,6224,3921,2197,6217,6229,8664,6188,8666,3646,8894,6208,27335	RPS5,RPS15,EIF1AX,RPS10,RPS28,RPS17,RPS26,RPS27L,RPS7,RPS23,RPS29,EIF2S1,RPS11,RPS4X,RPS12,RPS2,RPS27A,RPS9,RPS13,EIF3J,RPS20,RPSA,FAU,RPS16,RPS24,EIF3D,RPS3,EIF3G,EIF3E,EIF2S2,RPS14,EIF3K
R-HSA-5602358	Diseases associated with the TLR signaling cascade	1.39932211715443e-05	-11.1769375476452	24	18	0.00557448126354909	3229	10285	929,114609,7096,4792,4615,10333,4793,3551,7097,948,7098,7099,81793,51135,148022,4790,23643,7100	CD14,TIRAP,TLR1,NFKBIA,MYD88,TLR6,NFKBIB,IKBKB,TLR2,CD36,TLR3,TLR4,TLR10,IRAK4,TICAM1,NFKB1,LY96,TLR5
R-HSA-5260271	Diseases of Immune System	1.39932211715443e-05	-11.1769375476452	24	18	0.00557448126354909	3229	10285	7100,23643,4790,148022,51135,81793,7099,7098,3551,948,7097,4793,10333,4615,4792,7096,929,114609	TLR5,LY96,NFKB1,TICAM1,IRAK4,TLR10,TLR4,TLR3,IKBKB,CD36,TLR2,NFKBIB,TLR6,MYD88,NFKBIA,TLR1,CD14,TIRAP
R-HSA-166054	Activated TLR4 signalling	1.49659281337436e-05	-11.1097343982859	115	58	0.0179622174047693	3229	10285	29110,4792,5606,7096,6500,948,5518,57162,7314,246330,7311,7099,5781,5604,4208,10333,6285,1848,10454,2353,2002,1385,10010,23291,23643,3725,177,51135,4790,4615,929,1845,7189,3146,7321,329,353376,7097,3551,23098,6233,7323,7334,114609,5602,3661,7867,7098,5608,466,23118,4793,1660,4205,3665,7335,148022,5516	TBK1,NFKBIA,MAP2K3,TLR1,SKP1,CD36,PPP2R1A,PELI1,UBB,PELI3,UBA52,TLR4,PTPN11,MAP2K1,MEF2C,TLR6,S100B,DUSP6,TAB1,FOS,ELK1,CREB1,TANK,FBXW11,LY96,JUN,AGER,IRAK4,NFKB1,MYD88,CD14,DUSP3,TRAF6,HMGB1,UBE2D1,BIRC2,TICAM2,TLR2,IKBKB,SARM1,RPS27A,UBE2D3,UBE2N,TIRAP,MAPK10,IRF3,MAPKAPK3,TLR3,MAP2K6,ATF1,TAB2,NFKBIB,DHX9,MEF2A,IRF7,UBE2V1,TICAM1,PPP2CB
R-HSA-5358346	Hedgehog ligand biogenesis	1.50838567459443e-05	-11.1018854757	67	38	0.0117683493341592	3229	10285	5700,5704,27248,5718,5684,5693,5689,10956,5695,5709,5687,5691,5683,5694,5707,5690,5699,5686,5705,122706,5685,5713,7979,5698,5692,5720,9861,5716,5721,7314,5710,84447,6233,7311,5682,51009,5702,10213	PSMC1,PSMC4,ERLEC1,PSMD12,PSMA3,PSMB5,PSMB1,OS9,PSMB7,PSMD3,PSMA6,PSMB3,PSMA2,PSMB6,PSMD1,PSMB2,PSMB10,PSMA5,PSMC5,PSMB11,PSMA4,PSMD7,SEM1,PSMB9,PSMB4,PSME1,PSMD6,PSMD10,PSME2,UBB,PSMD4,SYVN1,RPS27A,UBA52,PSMA1,DERL2,PSMC3,PSMD14
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	1.5559904727778e-05	-11.0708131621262	197	90	0.0278724063177454	3229	10285	79837,3265,2549,5516,3815,10000,207,5687,5290,5707,5690,8823,8915,5700,8870,942,5682,7157,5702,5710,6233,5692,3551,25780,7979,8074,5686,5728,4233,4790,5691,5529,8394,29851,5296,5525,2246,4193,3845,57690,7311,27006,6714,5716,4792,2255,118788,4343,208,8503,5579,1026,4793,5718,2252,2931,572,9861,1839,2248,5721,5698,2260,5705,122706,5699,5685,940,5694,5683,23291,5295,5689,1385,5709,5695,1027,5704,5693,5684,5781,10213,7314,5518,6500,5720,26523,5713,8822,941	PIP4K2C,HRAS,GAB1,PPP2CB,KIT,AKT3,AKT1,PSMA6,PIK3CA,PSMD1,PSMB2,FGF16,BCL10,PSMC1,IER3,CD86,PSMA1,TP53,PSMC3,PSMD4,RPS27A,PSMB4,IKBKB,RASGRP3,SEM1,FGF23,PSMA5,PTEN,MET,NFKB1,PSMB3,PPP2R5E,PIP5K1A,ICOS,PIK3R2,PPP2R5A,FGF1,MDM2,KRAS,TNRC6C,UBA52,FGF22,SRC,PSMD10,NFKBIA,FGF10,PIK3AP1,MOV10,AKT2,PIK3R3,PRKCB,CDKN1A,NFKBIB,PSMD12,FGF7,GSK3A,BAD,PSMD6,HBEGF,FGF3,PSME2,PSMB9,FGFR1,PSMC5,PSMB11,PSMB10,PSMA4,CD28,PSMB6,PSMA2,FBXW11,PIK3R1,PSMB1,CREB1,PSMD3,PSMB7,CDKN1B,PSMC4,PSMB5,PSMA3,PTPN11,PSMD14,UBB,PPP2R1A,SKP1,PSME1,AGO1,PSMD7,FGF17,CD80
R-HSA-73857	RNA Polymerase II Transcription	2.02181397068824e-05	-10.8089303512314	159	75	0.0232270052647879	3229	10285	6917,5441,5433,6637,2966,6628,2963,2958,84248,6827,5436,6921,6881,6879,5435,5431,6873,100126351,4331,1022,2961,65109,10898,23283,100302196,9984,4116,6429,902,9877,2957,693221,22794,51362,6426,404672,6880,6635,29894,10914,22916,6634,55840,7919,6829,84271,1479,84321,10569,57187,2960,26097,55110,79577,5438,79228,84967,2962,25888,80349,10978,2968,53981,5432,6749,6427,6432,2071,9785,6882,2959,10189,1025,9775,10212	TCEA1,POLR2L,POLR2D,SNRPG,GTF2H2,SNRPB,GTF2F2,GTF2A2,FYTTD1,SUPT4H1,POLR2G,ELOC,TAF10,TAF7,POLR2F,POLR2B,TAF2,MIR939,MNAT1,CDK7,GTF2E2,UPF3B,CPSF4,CSTF2T,MIR1234,THOC1,MAGOH,SRSF4,CCNH,ZC3H11A,GTF2A1,MIR636,CASC3,CDC40,SRSF1,GTF2H5,TAF9,SNRPE,CPSF1,PAPOLA,NCBP2,SNRPD3,EAF2,DDX39B,SUPT5H,POLDIP3,CSTF3,THOC3,SLU7,THOC2,GTF2E1,CHTOP,MAGOHB,CDC73,POLR2I,THOC6,LSM10,GTF2F1,ZNF473,SKIC8,CLP1,GTF2H4,CPSF2,POLR2C,SSRP1,SRSF2,SRSF7,ERCC3,DHX38,TAF11,GTF2B,ALYREF,CDK9,EIF4A3,DDX39A
R-HSA-5658442	Regulation of RAS by GAPs	2.05986456869752e-05	-10.7902852276806	70	39	0.0120780427376897	3229	10285	5718,5704,8452,5700,5693,5684,5689,5709,5695,5691,5687,5690,5707,5683,5694,122706,5705,5699,5686,3265,5685,5713,5698,200734,7979,9861,5720,5692,5721,5716,5710,7314,161742,7311,6233,3845,5682,5702,10213	PSMD12,PSMC4,CUL3,PSMC1,PSMB5,PSMA3,PSMB1,PSMD3,PSMB7,PSMB3,PSMA6,PSMB2,PSMD1,PSMA2,PSMB6,PSMB11,PSMC5,PSMB10,PSMA5,HRAS,PSMA4,PSMD7,PSMB9,SPRED2,SEM1,PSMD6,PSME1,PSMB4,PSME2,PSMD10,PSMD4,UBB,SPRED1,UBA52,RPS27A,KRAS,PSMA1,PSMC3,PSMD14
R-HSA-5357801	Programmed Cell Death	2.28271107600466e-05	-10.6875616599627	175	81	0.0250851656859709	3229	10285	7533,7314,7099,4000,7311,3007,581,10213,5588,7534,5713,1613,6093,1676,3836,5720,578,5716,5691,51765,6709,5683,5694,2810,122706,5705,5699,23643,5686,5366,356,5685,5704,5684,5693,3024,7529,5689,6304,5709,5695,7029,5710,4001,6233,7186,8655,5682,355,5702,7157,1499,572,3009,5698,7979,929,598,2620,9861,3146,5062,5692,353376,329,5721,8743,10000,5687,207,5690,5707,8428,208,118,7532,148022,5718,5700,7098,1612	YWHAH,UBB,TLR4,LMNA,UBA52,H1-3,BAX,PSMD14,PRKCQ,YWHAZ,PSMD7,DAPK3,ROCK1,DFFA,KPNA1,PSME1,BAK1,PSMD10,PSMB3,STK26,SPTAN1,PSMA2,PSMB6,SFN,PSMB11,PSMC5,PSMB10,LY96,PSMA5,PMAIP1,FASLG,PSMA4,PSMC4,PSMA3,PSMB5,H1-1,YWHAB,PSMB1,SATB1,PSMD3,PSMB7,TFDP2,PSMD4,LMNB1,RPS27A,TRAF2,DYNLL1,PSMA1,FAS,PSMC3,TP53,CTNNB1,BAD,H1-5,PSMB9,SEM1,CD14,BCL2L1,GAS2,PSMD6,HMGB1,PAK2,PSMB4,TICAM2,BIRC2,PSME2,TNFSF10,AKT3,PSMA6,AKT1,PSMB2,PSMD1,STK24,AKT2,ADD1,YWHAG,TICAM1,PSMD12,PSMC1,TLR3,DAPK1
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	3.36028539149222e-05	-10.300899556658	311	131	0.0405698358624961	3229	10285	9021,9870,55070,6737,64410,5686,7328,10075,6477,6468,27246,25847,5691,140460,26249,10616,4591,25898,5716,26224,79654,54620,26268,390594,27338,51665,10533,7311,80176,84085,255488,5700,8452,7334,26235,51130,7335,9604,84937,899,57154,5687,3093,25793,5690,5707,8697,5692,29945,7979,5682,7323,84861,5702,51529,79791,5710,7325,6233,5689,84676,22954,991,114907,5695,29116,8881,5709,5704,5684,5693,5699,5705,122706,55284,5685,7704,80196,23291,5694,5683,7337,10477,5720,7320,9039,6500,140461,23194,8453,84231,5713,140456,6921,6478,81559,7319,25831,7327,10213,7332,7314,140739,246184,8916,5718,55958,11059,7336,26091,26263,55521,9861,29882,5721,7321,10273,10193,55294,55658,26118,51343,5698,89890,221687,144699,9040,23376,93611,9616,51132	SOCS3,AREL1,DET1,TRIM21,KLHL25,PSMA5,UBE2H,HUWE1,SIAH1,FBXW4,RNF115,ANAPC13,PSMB3,ASB7,KLHL3,RBCK1,TRIM37,RCHY1,PSMD10,FBXL3,HECTD3,FBXL19,FBXO9,KBTBD13,UBE2S,ASB1,ATG7,UBA52,SPSB1,FBXO30,RNF144B,PSMC1,CUL3,UBE2N,FBXL4,ASB3,UBE2V1,RNF14,ZNRF1,CCNF,SMURF1,PSMA6,UBE2K,FBXO7,PSMB2,PSMD1,CDC23,PSMB4,ANAPC4,SEM1,PSMA1,UBE2D3,KLHL22,PSMC3,ANAPC11,FBXO31,PSMD4,UBE2E2,RPS27A,PSMB1,TRIM63,TRIM32,CDC20,FBXO32,PSMB7,MYLIP,CDC16,PSMD3,PSMC4,PSMA3,PSMB5,PSMB10,PSMC5,PSMB11,UBE2W,PSMA4,ZBTB16,RNF34,FBXW11,PSMB6,PSMA2,UBE3A,UBE2E3,PSME1,UBE2B,UBA3,SKP1,ASB8,FBXL7,CUL2,TRAF7,PSMD7,ASB11,ELOC,SIAH2,TRIM11,UBE2A,HECTD1,UBE2G2,PSMD14,UBE2L3,UBB,UBE2F,CDC26,HERC3,PSMD12,KLHL9,WWP1,UBE2V2,HERC4,FBXO22,TRIM36,PSMD6,ANAPC2,PSME2,UBE2D1,STUB1,RNF41,FBXW7,RNF126,WSB1,FZR1,PSMB9,KBTBD6,RNF182,FBXL14,UBE2M,UFL1,FBXO44,RNF7,RLIM
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	3.71839000120826e-05	-10.1996346857422	93	48	0.0148652833694642	3229	10285	3551,353376,1845,7189,3146,929,4615,6233,23118,466,4793,7867,7098,5608,5602,7334,148022,5516,3665,7335,4205,1660,6500,5606,51284,4792,4208,5604,7099,7311,57162,5518,246330,7314,2002,1385,10454,2353,6285,1848,51135,4790,23643,51311,3725,177,54106,23291	IKBKB,TICAM2,DUSP3,TRAF6,HMGB1,CD14,MYD88,RPS27A,TAB2,ATF1,NFKBIB,MAPKAPK3,TLR3,MAP2K6,MAPK10,UBE2N,TICAM1,PPP2CB,IRF7,UBE2V1,MEF2A,DHX9,SKP1,MAP2K3,TLR7,NFKBIA,MEF2C,MAP2K1,TLR4,UBA52,PELI1,PPP2R1A,PELI3,UBB,ELK1,CREB1,TAB1,FOS,S100B,DUSP6,IRAK4,NFKB1,LY96,TLR8,JUN,AGER,TLR9,FBXW11
R-HSA-975155	MyD88 dependent cascade initiated on endosome	3.71839000120826e-05	-10.1996346857422	93	48	0.0148652833694642	3229	10285	1845,3146,7189,3551,353376,4615,929,6233,7098,7867,5608,23118,466,4793,7334,5602,3665,7335,148022,5516,1660,4205,6500,4792,5606,51284,5604,4208,57162,5518,246330,7314,7099,7311,2002,1385,1848,6285,10454,2353,23643,51311,3725,177,51135,4790,54106,23291	DUSP3,HMGB1,TRAF6,IKBKB,TICAM2,MYD88,CD14,RPS27A,TLR3,MAPKAPK3,MAP2K6,TAB2,ATF1,NFKBIB,UBE2N,MAPK10,IRF7,UBE2V1,TICAM1,PPP2CB,DHX9,MEF2A,SKP1,NFKBIA,MAP2K3,TLR7,MAP2K1,MEF2C,PELI1,PPP2R1A,PELI3,UBB,TLR4,UBA52,ELK1,CREB1,DUSP6,S100B,TAB1,FOS,LY96,TLR8,JUN,AGER,IRAK4,NFKB1,TLR9,FBXW11
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	4.36525627220302e-05	-10.0392485667026	91	47	0.0145555899659337	3229	10285	4792,51284,5606,6500,7314,246330,5518,57162,7311,7099,5604,4208,6285,1848,2353,10454,1385,2002,23291,54106,3725,177,51311,23643,4790,51135,4615,929,3146,7189,1845,353376,3551,6233,7334,5602,5608,7098,7867,4793,466,23118,1660,4205,7335,5516,148022	NFKBIA,TLR7,MAP2K3,SKP1,UBB,PELI3,PPP2R1A,PELI1,UBA52,TLR4,MAP2K1,MEF2C,S100B,DUSP6,FOS,TAB1,CREB1,ELK1,FBXW11,TLR9,JUN,AGER,TLR8,LY96,NFKB1,IRAK4,MYD88,CD14,HMGB1,TRAF6,DUSP3,TICAM2,IKBKB,RPS27A,UBE2N,MAPK10,MAP2K6,TLR3,MAPKAPK3,NFKBIB,ATF1,TAB2,DHX9,MEF2A,UBE2V1,PPP2CB,TICAM1
R-HSA-5621481	C-type lectin receptors (CLRs)	4.63189150870372e-05	-9.9799601471017	144	68	0.0210591514400743	3229	10285	10213,3845,5567,7311,6850,30835,7314,5894,5716,5720,6714,9039,6500,4792,2033,5713,2207,5685,4790,5699,5686,5705,122706,23291,93978,5694,5683,5691,5695,5709,5689,10768,10454,5693,5684,5704,5702,5682,3553,6233,9040,5710,5530,5721,7321,3551,5692,64581,5062,7189,9861,7979,5698,3265,3385,7335,29108,5690,5707,5687,9020,23118,8915,3384,5700,7334,1387,5718	PSMD14,KRAS,PRKACB,UBA52,SYK,CD209,UBB,RAF1,PSMD10,PSME1,SRC,UBA3,SKP1,NFKBIA,EP300,PSMD7,FCER1G,PSMA4,NFKB1,PSMB10,PSMA5,PSMC5,PSMB11,FBXW11,CLEC6A,PSMB6,PSMA2,PSMB3,PSMB7,PSMD3,PSMB1,AHCYL1,TAB1,PSMB5,PSMA3,PSMC4,PSMC3,PSMA1,IL1B,RPS27A,UBE2M,PSMD4,PPP3CA,PSME2,UBE2D1,IKBKB,PSMB4,CLEC7A,PAK2,TRAF6,PSMD6,SEM1,PSMB9,HRAS,ICAM3,UBE2V1,PYCARD,PSMB2,PSMD1,PSMA6,MAP3K14,TAB2,BCL10,ICAM2,PSMC1,UBE2N,CREBBP,PSMD12
R-HSA-168249	Innate Immune System	5.10933690980472e-05	-9.8818558324222	1285	465	0.144007432641685	3229	10285	4153,3665,6836,11010,966,6778,5049,729230,10787,207,5290,3320,5707,10695,5608,8915,23118,245930,115004,8452,1509,5682,80143,1513,25780,10383,2040,598,5273,4233,4790,51135,10075,152559,3428,8394,10010,3561,1774,5296,3326,2002,1848,3845,10577,57690,57506,27006,81793,8673,2268,948,829,245929,3163,196051,2495,7096,3958,3385,1660,53358,10694,5581,7520,8635,7098,1437,55832,684,3716,3553,967,4296,572,51125,3728,9040,329,4620,3559,177,2260,5685,5694,5683,25840,108,917,7133,5689,10768,5704,7410,5873,5781,10213,5435,3937,57162,5265,171568,5441,9844,140683,284,5153,6711,5775,5269,5606,7130,79837,3815,3567,534,3093,51209,1672,818,10628,11333,84265,8823,9020,57826,3240,823,7334,7450,3446,10549,942,7323,7157,23406,5547,23646,327,1072,6233,55703,5870,1845,64581,114548,25801,1471,1843,5236,3822,2683,23586,9145,51382,837,3440,5686,2207,5691,5037,919,7525,528,54106,29851,6616,2171,10333,6590,7529,998,1508,25852,4860,5266,11240,6714,1852,55754,10817,29110,4792,5478,6727,51284,5878,1915,148022,10043,22875,4311,2204,8503,7867,920,4793,5476,466,51719,5602,3577,22861,5530,4747,11221,11031,5721,3456,4615,7184,200734,3725,7305,3558,4973,567,714,1785,6279,940,1742,8315,1445,1075,23291,3702,22954,5295,11026,1385,3920,3660,1027,64114,7099,3312,5578,10810,245934,26523,5536,23385,90423,25798,10875,8822,941,63916,149954,7335,51646,9588,3265,5516,175,10120,8682,5690,203068,8649,1387,6515,5700,374395,10109,1499,5710,5245,1476,3685,3562,5062,3417,4069,3551,6464,7097,374403,10097,7462,5728,12,6709,8987,6737,84418,6402,2246,60,2212,5627,10454,9636,116842,80301,5604,965,51552,246330,5894,4718,8992,6850,6386,4831,3659,830,5716,258010,4318,6093,4343,208,1191,1113,245928,29108,2512,58485,8976,5718,92747,7128,3661,2209,10621,8655,9402,2931,23197,10396,23098,7189,2248,5698,122706,23643,7100,3824,51517,1460,8773,4282,3717,29099,4179,5912,820,5663,4208,7314,5518,51806,5720,3043,9550,3608,51082,4690,9342,26999,5834,2549,28956,1235,1116,6039,10000,5687,3560,8870,2665,10094,1938,7186,54472,5702,161742,3146,5692,523,353376,22931,929,7979,8904,10576,8074,51311,93978,5136,5529,245937,5864,3447,6285,391,5525,4193,1727,5588,5908,10533,10235,7311,30835,84292,23412,2033,2255,118788,3074,9545,8887,54918,5906,4205,1026,140881,114609,2252,5223,533,3384,55004,56729,961,4758,23593,9861,80331,8836,1839,326624,8778,7321,2220,6282,7295,94103,5705,5699,8560,2950,5709,5611,5695,51316,5693,5684,2919,2353,7276,109,10857,8907,5567,6500,64135,9039,79980,10159,5713,1992	MBL2,IRF7,SURF4,GLIPR1,CD59,STAT6,PAFAH1B2,CCR2,NCKAP1,AKT1,PIK3CA,HSP90AA1,PSMD1,CNPY3,MAP2K6,BCL10,TAB2,DEFB116,CGAS,CUL3,CTSD,PSMA1,SIKE1,CTSK,RASGRP3,TUBB4B,STOM,BCL2L1,SERPINB10,MET,NFKB1,IRAK4,HUWE1,PAQR3,IFI16,PIP5K1A,TANK,IL2RG,DNASE1L1,PIK3R2,HSP90AB1,ELK1,DUSP6,KRAS,NPC2,TNRC6C,MAVS,FGF22,TLR10,VAMP8,FGR,CD36,CAPZA1,DEFB115,HMOX2,PLPP4,FTH1,TLR1,LGALS3,ICAM3,DHX9,SHC3,CCT8,PRKCE,XRCC5,RNASET2,TLR3,CSF2,CAND1,BST2,JAK1,IL1B,CD63,MAP3K11,BAD,GOLGA7,JUP,UBE2M,BIRC2,MYH2,IL2RA,AGER,FGFR1,PSMA4,PSMB6,PSMA2,TMT1A,ADCY2,CD3G,TNFRSF1B,PSMB1,AHCYL1,PSMC4,VAV2,RAB27A,PTPN11,PSMD14,POLR2F,LCP2,PELI1,SERPINA1,POLR3H,POLR2L,ELMO1,BPIFA2,ANGPT1,PDE1B,SPTBN1,PTPN4,SERPINB6,MAP2K3,TNFAIP6,PIP4K2C,KIT,IL5,ATP6V1G2,UBE2K,RAB9B,DEFB1,CAMK2G,TXNIP,PDAP1,POLR3GL,FGF16,MAP3K14,RAP2C,HP,CAPN1,UBE2N,VWF,IFNA10,PRDX4,CD86,UBE2D3,TP53,COTL1,PRCP,PLD3,APEH,CFL1,RPS27A,POLR3B,RAB6A,DUSP3,CLEC7A,NLRP3,GCA,CST3,DUSP1,PGM1,KLRC2,B4GALT1,RIGI,SYNGR1,ATP6V1D,CASP4,IFNA2,PSMA5,FCER1G,PSMB3,PEBP1,CD247,YES1,ATP6V1C1,TLR9,ICOS,SNAP25,FABP5,TLR6,SLPI,YWHAB,CDC42,CTSB,ARMC8,PNP,PI3,PADI2,SRC,DUSP9,TMEM30A,FRS3,TBK1,NFKBIA,PPIA,SRP14,TLR7,RAB5C,EEF1A1,TICAM1,TOM1,ENPP4,MME,FCAR,PIK3R3,MAPKAPK3,CD4,NFKBIB,CTSA,ATF1,CAB39,MAPK10,CXCR1,NLRP1,PPP3CA,NEFL,DUSP10,RAB31,PSME2,IFNB1,MYD88,HSP90B1,SPRED2,JUN,TYROBP,IL2,OLR1,B2M,C1QC,DNM2,S100A8,CD28,DLG4,BRAP,CSK,CTSC,FBXW11,ITK,TRIM32,PIK3R1,LILRA3,CREB1,LAMP2,IRF2,CDKN1B,TMBIM1,TLR4,HSPA8,PRKCA,WASF3,DEFB121,AGO1,PPP5C,NCSTN,ATP6V1E2,BRI3,FGL2,FGF17,CD80,ELMO2,BPIFB4,UBE2V1,YPEL5,PRDX6,HRAS,PPP2CB,AGA,ACTR1B,PEA15,PSMB2,TUBB,LAMTOR3,CREBBP,SLC2A3,PSMC1,TMEM179B,ARPC2,CTNNB1,PSMD4,PHB1,CSTB,ITGAV,IL3,PAK2,IDH1,LYZ,IKBKB,SHC1,TLR2,TBC1D10C,ACTR2,LAT2,PTEN,SERPINA3,SPTAN1,STBD1,TRIM21,CYSTM1,SELL,FGF1,ACTB,FCGR2A,PROS1,TAB1,ISG15,LEAP2,PLEKHO2,MAP2K1,CD58,RAB14,PELI3,RAF1,NDUFC2,ATP6V0E1,SYK,SDCBP,NME2,IRF1,CAPZA2,PSMD10,SVIP,MMP9,ROCK1,MOV10,AKT2,CLU,CHGA,DEFB114,PYCARD,FTL,TRAPPC1,WASL,PSMD12,BPIFB1,TNFAIP3,IRF3,FCGR1A,POLR3F,DYNLL1,GRAP2,GSK3A,FAF2,ATP8A1,SARM1,TRAF6,FGF3,PSMB9,PSMB11,LY96,TLR5,KLRD1,NCKIPSD,CSNK2B,SNAP23,MIF,JAK2,COMMD9,CD46,RAP2B,CAMP,PSEN1,MEF2C,UBB,PPP2R1A,CALML5,PSME1,HBB,ATP6V1G1,ILF2,POLR1D,NCK1,SNAP29,CYFIP2,PYGB,GAB1,LAMTOR2,CCR6,CHI3L1,RNASE6,AKT3,PSMA6,IL2RB,IER3,GDI2,ARPC3,EEF2,TRAF2,TOLLIP,PSMC3,SPRED1,HMGB1,PSMB4,ATP6V1A,TICAM2,RAB18,CD14,SEM1,CPNE1,CCT2,FGF23,TLR8,CLEC6A,PDE1A,PPP2R5E,DEFB124,RAB3A,IFNA13,S100B,RHOG,PPP2R5A,MDM2,CYB5R3,PRKCQ,RAP1B,ATG7,RASGRP2,UBA52,CD209,WDR83,COMMD3,EP300,FGF10,PIK3AP1,HEXB,RAB3D,TAX1BP1,CMTM6,RAP1A,MEF2A,CDKN1A,DEFB129,TIRAP,FGF7,PGAM1,ATP6V0B,ICAM2,LAMTOR1,RETN,CD47,NEU1,HEBP2,PSMD6,DNAJC5,GGH,HBEGF,RAB37,SIGLEC5,UBE2D1,FCN2,S100A11,TXN,ORMDL3,PSMC5,PSMB10,DEGS1,GSTP1,PSMD3,DNAJC3,PSMB7,PLAC8,PSMB5,PSMA3,CXCL1,FOS,TTR,ADCY3,PGRMC1,AP1M1,PRKACB,SKP1,IFIH1,UBA3,DSN1,ATP6AP2,PSMD7,SERPINB1
R-HSA-6783783	Interleukin-10 signaling	5.26954556519083e-05	-9.8509813366491	49	29	0.00898110870238464	3229	10285	3552,3383,3565,729230,6364,2919,6352,3716,1230,3569,1234,3606,6347,1437,6363,3592,7133,3576,7124,7850,7076,942,3553,3586,3593,941,3627,6348,3596	IL1A,ICAM1,IL4,CCR2,CCL20,CXCL1,CCL5,JAK1,CCR1,IL6,CCR5,IL18,CCL2,CSF2,CCL19,IL12A,TNFRSF1B,CXCL8,TNF,IL1R2,TIMP1,CD86,IL1B,IL10,IL12B,CD80,CXCL10,CCL3,IL13
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	5.42303276922612e-05	-9.82227025449152	99	50	0.0154846701765252	3229	10285	10010,23291,23643,3725,177,4790,6285,1848,10454,2353,2002,1385,5518,7314,7311,7099,5781,5604,4208,29110,4792,5606,6500,1660,4205,3665,7335,148022,5516,7334,5602,3661,7867,7098,5608,466,23118,4793,23098,6233,7323,4615,929,1845,3146,7189,7321,329,353376,3551	TANK,FBXW11,LY96,JUN,AGER,NFKB1,S100B,DUSP6,TAB1,FOS,ELK1,CREB1,PPP2R1A,UBB,UBA52,TLR4,PTPN11,MAP2K1,MEF2C,TBK1,NFKBIA,MAP2K3,SKP1,DHX9,MEF2A,IRF7,UBE2V1,TICAM1,PPP2CB,UBE2N,MAPK10,IRF3,MAPKAPK3,TLR3,MAP2K6,ATF1,TAB2,NFKBIB,SARM1,RPS27A,UBE2D3,MYD88,CD14,DUSP3,HMGB1,TRAF6,UBE2D1,BIRC2,TICAM2,IKBKB
R-HSA-166166	MyD88-independent TLR3/TLR4 cascade	5.42303276922612e-05	-9.82227025449152	99	50	0.0154846701765252	3229	10285	6285,1848,2353,10454,1385,2002,23291,10010,177,3725,23643,4790,4792,29110,5606,6500,7314,5518,7311,7099,5604,5781,4208,7334,3661,5602,5608,7867,7098,4793,466,23118,1660,4205,7335,3665,5516,148022,4615,929,3146,7189,1845,353376,3551,7321,329,23098,6233,7323	S100B,DUSP6,FOS,TAB1,CREB1,ELK1,FBXW11,TANK,AGER,JUN,LY96,NFKB1,NFKBIA,TBK1,MAP2K3,SKP1,UBB,PPP2R1A,UBA52,TLR4,MAP2K1,PTPN11,MEF2C,UBE2N,IRF3,MAPK10,MAP2K6,MAPKAPK3,TLR3,NFKBIB,ATF1,TAB2,DHX9,MEF2A,UBE2V1,IRF7,PPP2CB,TICAM1,MYD88,CD14,HMGB1,TRAF6,DUSP3,TICAM2,IKBKB,UBE2D1,BIRC2,SARM1,RPS27A,UBE2D3
R-HSA-937061	TRIF-mediated TLR3/TLR4 signaling	5.42303276922612e-05	-9.82227025449152	99	50	0.0154846701765252	3229	10285	23643,3725,177,4790,10010,23291,2002,1385,1848,6285,10454,2353,5781,5604,4208,5518,7314,7311,7099,6500,4792,29110,5606,3665,7335,148022,5516,1660,4205,7098,7867,5608,466,23118,4793,7334,5602,3661,7323,23098,6233,1845,3146,7189,7321,329,353376,3551,4615,929	LY96,JUN,AGER,NFKB1,TANK,FBXW11,ELK1,CREB1,DUSP6,S100B,TAB1,FOS,PTPN11,MAP2K1,MEF2C,PPP2R1A,UBB,UBA52,TLR4,SKP1,NFKBIA,TBK1,MAP2K3,IRF7,UBE2V1,TICAM1,PPP2CB,DHX9,MEF2A,TLR3,MAPKAPK3,MAP2K6,ATF1,TAB2,NFKBIB,UBE2N,MAPK10,IRF3,UBE2D3,SARM1,RPS27A,DUSP3,HMGB1,TRAF6,UBE2D1,BIRC2,TICAM2,IKBKB,MYD88,CD14
R-HSA-382556	ABC-family proteins mediated transport	6.45274704786272e-05	-9.64841952593829	107	53	0.0164137503871168	3229	10285	8504,5707,5690,1244,5687,6041,79139,10613,5700,1080,5718,23,5702,1965,5243,5682,6233,11160,5710,5721,5692,9861,7979,5698,6059,5685,5686,5699,8894,122706,5705,5694,5683,5691,5695,5709,10057,5689,10956,5693,5684,5704,23457,27248,10213,51009,6048,7311,7314,5716,3767,5720,5713	PEX3,PSMD1,PSMB2,ABCC2,PSMA6,RNASEL,DERL1,ERLIN1,PSMC1,CFTR,PSMD12,ABCF1,PSMC3,EIF2S1,ABCB1,PSMA1,RPS27A,ERLIN2,PSMD4,PSME2,PSMB4,PSMD6,SEM1,PSMB9,ABCE1,PSMA4,PSMA5,PSMB10,EIF2S2,PSMB11,PSMC5,PSMB6,PSMA2,PSMB3,PSMB7,PSMD3,ABCC5,PSMB1,OS9,PSMB5,PSMA3,PSMC4,ABCB9,ERLEC1,PSMD14,DERL2,RNF5,UBA52,UBB,PSMD10,KCNJ11,PSME1,PSMD7
R-HSA-5602498	MyD88 deficiency (TLR2/4)	7.24932377775017e-05	-9.53201727248821	11	10	0.00309693403530505	3229	10285	51135,7097,948,23643,114609,929,7096,7099,4615,10333	IRAK4,TLR2,CD36,LY96,TIRAP,CD14,TLR1,TLR4,MYD88,TLR6
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	7.24932377775017e-05	-9.53201727248821	11	10	0.00309693403530505	3229	10285	4615,10333,114609,929,7099,7096,23643,51135,7097,948	MYD88,TLR6,TIRAP,CD14,TLR4,TLR1,LY96,IRAK4,TLR2,CD36
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	7.72198965360646e-05	-9.46885340698839	43	26	0.00805202849179312	3229	10285	6950,55970,54331,10574,406974,2782,1457,59345,2788,22948,2771,5082,9628,1460,2781,2793,2784,10694,51764,2785,2773,2787,2791,2775,2790,10576	TCP1,GNG12,GNG2,CCT7,MIR197,GNB1,CSNK2A1,GNB4,GNG7,CCT5,GNAI2,PDCL,RGS6,CSNK2B,GNAZ,GNGT2,GNB3,CCT8,GNG13,GNG3,GNAI3,GNG5,GNG11,GNAO1,GNG10,CCT2
R-HSA-937041	IKK complex recruitment mediated by RIP1	8.1978929275049e-05	-9.40904830378029	24	17	0.00526478786001858	3229	10285	148022,7323,23643,7335,6233,23098,7099,7311,7314,329,7321,3551,353376,7098,7189,929,7334	TICAM1,UBE2D3,LY96,UBE2V1,RPS27A,SARM1,TLR4,UBA52,UBB,BIRC2,UBE2D1,IKBKB,TICAM2,TLR3,TRAF6,CD14,UBE2N
R-HSA-195253	Degradation of beta-catenin by the destruction complex	8.29730764220822e-05	-9.39699438324724	83	43	0.0133168163518117	3229	10285	1487,7311,5518,7314,10213,5713,5716,5720,6500,5529,5694,5683,5691,5685,5686,5699,122706,5705,5684,5693,5704,5525,5695,5709,5689,6233,5710,1499,5702,5682,7979,5698,5721,5692,9861,5690,5707,1452,5687,5516,7088,5700,5718	CTBP1,UBA52,PPP2R1A,UBB,PSMD14,PSMD7,PSMD10,PSME1,SKP1,PPP2R5E,PSMB6,PSMA2,PSMB3,PSMA4,PSMA5,PSMB10,PSMB11,PSMC5,PSMA3,PSMB5,PSMC4,PPP2R5A,PSMB7,PSMD3,PSMB1,RPS27A,PSMD4,CTNNB1,PSMC3,PSMA1,SEM1,PSMB9,PSME2,PSMB4,PSMD6,PSMB2,PSMD1,CSNK1A1,PSMA6,PPP2CB,TLE1,PSMC1,PSMD12
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	8.45123857515039e-05	-9.37861245740162	372	151	0.0467637039331062	3229	10285	84292,7311,6850,27006,5894,10235,57690,5908,5588,3845,5604,4343,4792,2255,118788,5716,10817,1852,6714,8394,5529,6709,5691,5037,2207,152559,4233,4790,7462,5686,5728,8074,10454,7529,4193,5525,2246,1848,3561,5296,29851,3562,6233,161742,5710,5245,7157,5702,5682,942,7979,1843,25780,6464,3551,5692,5062,5690,5707,8682,10000,5687,207,5290,3567,3265,2549,5516,3815,28956,79837,7335,7450,8452,5700,8870,7334,23118,8915,8823,8649,818,3560,5518,3937,7314,10213,5781,8822,941,5713,5536,26523,6711,284,5720,6500,5683,3702,23291,5694,8315,1445,940,1742,5685,5699,2260,5705,3558,3725,122706,7410,5693,5684,2353,5704,1027,5695,3717,5709,1385,5689,10768,5295,4747,11221,5530,572,4296,2931,9402,200734,3559,5698,7321,5721,2248,1839,7189,9861,53358,5906,208,2252,3716,5602,5718,1437,8503,1026	WDR83,UBA52,SYK,FGF22,RAF1,RASGRP2,TNRC6C,RAP1B,PRKCQ,KRAS,MAP2K1,MOV10,NFKBIA,FGF10,PIK3AP1,PSMD10,FRS3,DUSP9,SRC,PIP5K1A,PPP2R5E,SPTAN1,PSMB3,PEBP1,FCER1G,PAQR3,MET,NFKB1,LAT2,PSMA5,PTEN,FGF23,TAB1,YWHAB,MDM2,PPP2R5A,FGF1,DUSP6,IL2RG,PIK3R2,ICOS,IL3,RPS27A,SPRED1,PSMD4,PHB1,TP53,PSMC3,PSMA1,CD86,SEM1,DUSP1,RASGRP3,SHC1,IKBKB,PSMB4,PAK2,PSMB2,PSMD1,PEA15,AKT3,PSMA6,AKT1,PIK3CA,IL5,HRAS,GAB1,PPP2CB,KIT,LAMTOR2,PIP4K2C,UBE2V1,VWF,CUL3,PSMC1,IER3,UBE2N,TAB2,BCL10,FGF16,LAMTOR3,CAMK2G,IL2RB,PPP2R1A,LCP2,UBB,PSMD14,PTPN11,FGF17,CD80,PSMD7,PPP5C,AGO1,SPTBN1,ANGPT1,PSME1,SKP1,PSMA2,ITK,FBXW11,PSMB6,BRAP,CSK,CD28,DLG4,PSMA4,PSMB10,FGFR1,PSMC5,IL2,JUN,PSMB11,VAV2,PSMB5,PSMA3,FOS,PSMC4,CDKN1B,PSMB7,JAK2,PSMD3,CREB1,PSMB1,AHCYL1,PIK3R1,NEFL,DUSP10,PPP3CA,BAD,MAP3K11,GSK3A,GRAP2,SPRED2,IL2RA,PSMB9,UBE2D1,PSME2,FGF3,HBEGF,TRAF6,PSMD6,SHC3,RAP1A,AKT2,FGF7,JAK1,MAPK10,PSMD12,CSF2,PIK3R3,CDKN1A
R-HSA-5389840	Mitochondrial translation elongation	8.60452096601272e-05	-9.3606377061169	88	45	0.0139362031588727	3229	10285	122704,64965,51373,64979,64981,124995,51081,51021,64963,60488,65993,51258,64432,92259,29074,7284,6182,63875,79590,54460,64976,57129,28973,54534,64975,9553,55052,28957,51649,51650,6150,740,64949,85476,51023,54998,118487,29093,65005,28998,54948,78988,116540,55168,65003	MRPL52,MRPS9,MRPS17,MRPL36,MRPL34,MRPL10,MRPS7,MRPS16,MRPS11,MRPS35,MRPS34,MRPL51,MRPS25,KGD4,MRPL18,TUFM,MRPL12,MRPL17,MRPL24,MRPS21,MRPL40,MRPL47,MRPS18B,MRPL50,MRPL41,MRPL33,MRPL20,MRPS28,MRPS23,MRPS33,MRPL23,MRPL49,MRPS26,GFM1,MRPS18C,AURKAIP1,CHCHD1,MRPL22,MRPL9,MRPL13,MRPL16,MRPL57,MRPL53,MRPS18A,MRPL11
R-HSA-3858494	Beta-catenin independent WNT signaling	8.79914607177239e-05	-9.33827078549308	149	69	0.0213688448436048	3229	10285	5684,5693,5145,5704,5709,5695,5689,160,5694,5683,51764,5691,5330,23236,2787,5685,2790,5705,122706,5686,5699,4343,55970,5713,54331,8322,5716,26523,5720,7311,5578,2782,7314,57690,10213,2788,23002,5718,5700,8323,5579,2793,2784,1856,1173,5690,5707,50855,5687,2785,57154,2791,1175,2775,5698,7979,5880,5721,9861,5692,7976,6233,5710,5530,100126338,5702,1499,59345,5682	PSMA3,PSMB5,PDE6A,PSMC4,PSMD3,PSMB7,PSMB1,AP2A1,PSMB6,PSMA2,GNG13,PSMB3,PLCB2,PLCB1,GNG5,PSMA4,GNG10,PSMC5,PSMB11,PSMA5,PSMB10,MOV10,GNG12,PSMD7,GNG2,FZD4,PSMD10,AGO1,PSME1,UBA52,PRKCA,GNB1,UBB,TNRC6C,PSMD14,GNG7,DAAM1,PSMD12,PSMC1,FZD6,PRKCB,GNGT2,GNB3,DVL2,AP2M1,PSMB2,PSMD1,PARD6A,PSMA6,GNG3,SMURF1,GNG11,AP2S1,GNAO1,PSMB9,SEM1,RAC2,PSME2,PSMD6,PSMB4,FZD3,RPS27A,PSMD4,PPP3CA,MIR937,PSMC3,CTNNB1,GNB4,PSMA1
R-HSA-8873719	RAB geranylgeranylation	9.06403727806479e-05	-9.30861082849208	64	35	0.0108392691235677	3229	10285	11031,10981,5876,9367,116442,9363,5862,5868,51552,51762,401409,57403,5873,115827,8766,8934,22931,83452,5870,326624,5872,51209,5865,9545,9230,11021,5878,5867,27314,5864,51715,51560,81876,5861,8073	RAB31,RAB32,RABGGTB,RAB9A,RAB39B,RAB33A,RAB2A,RAB5A,RAB14,RAB8B,RAB19,RAB22A,RAB27A,RAB3C,RAB11A,RAB29,RAB18,RAB33B,RAB6A,RAB37,RAB13,RAB9B,RAB3B,RAB3D,RAB11B,RAB35,RAB5C,RAB4A,RAB30,RAB3A,RAB23,RAB6B,RAB1B,RAB1A,PTP4A2
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	9.24312495969402e-05	-9.28904543739198	229	99	0.03065964694952	3229	10285	122706,2260,5705,5699,5685,940,5694,23291,5683,5295,10768,5689,5709,1385,5695,1027,5704,5693,5684,5781,10213,7314,867,5518,6500,5720,26523,5713,8822,941,80228,4690,208,1026,5579,8503,4793,5718,2252,2931,572,9861,1839,2248,5721,5698,8074,5728,5686,4790,4233,5691,8394,5529,29851,5296,2246,5525,4193,7220,6786,3845,57690,27006,6850,7311,6714,5716,118788,2255,974,4792,4343,79837,5516,3815,3265,2549,5290,5687,10000,207,5707,5690,8823,8915,8870,5700,942,5682,5702,7157,5710,6233,5692,3551,6464,25780,7979	PSMB11,FGFR1,PSMC5,PSMB10,PSMA4,CD28,PSMB6,FBXW11,PSMA2,PIK3R1,AHCYL1,PSMB1,PSMD3,CREB1,PSMB7,CDKN1B,PSMC4,PSMB5,PSMA3,PTPN11,PSMD14,UBB,CBL,PPP2R1A,SKP1,PSME1,AGO1,PSMD7,FGF17,CD80,ORAI2,NCK1,AKT2,CDKN1A,PRKCB,PIK3R3,NFKBIB,PSMD12,FGF7,GSK3A,BAD,PSMD6,HBEGF,FGF3,PSME2,PSMB9,FGF23,PTEN,PSMA5,NFKB1,MET,PSMB3,PIP5K1A,PPP2R5E,ICOS,PIK3R2,FGF1,PPP2R5A,MDM2,TRPC1,STIM1,KRAS,TNRC6C,FGF22,SYK,UBA52,SRC,PSMD10,PIK3AP1,FGF10,CD79B,NFKBIA,MOV10,PIP4K2C,PPP2CB,KIT,HRAS,GAB1,PIK3CA,PSMA6,AKT3,AKT1,PSMD1,PSMB2,FGF16,BCL10,IER3,PSMC1,CD86,PSMA1,PSMC3,TP53,PSMD4,RPS27A,PSMB4,IKBKB,SHC1,RASGRP3,SEM1
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	9.41885788887196e-05	-9.27021162695205	126	60	0.0185816042118303	3229	10285	1385,2002,10333,6285,1848,2353,10454,177,3725,23643,1785,4790,51135,23291,10010,6500,948,5775,4792,29110,7096,5606,5604,5781,4208,246330,7314,5518,57162,7311,7099,5608,7867,7098,4793,466,23118,7334,3661,114609,5602,7335,3665,5516,148022,1660,4205,3146,7189,1845,353376,7097,3551,7321,329,4615,929,7323,23098,6233	CREB1,ELK1,TLR6,S100B,DUSP6,FOS,TAB1,AGER,JUN,LY96,DNM2,NFKB1,IRAK4,FBXW11,TANK,SKP1,CD36,PTPN4,NFKBIA,TBK1,TLR1,MAP2K3,MAP2K1,PTPN11,MEF2C,PELI3,UBB,PPP2R1A,PELI1,UBA52,TLR4,MAP2K6,MAPKAPK3,TLR3,NFKBIB,ATF1,TAB2,UBE2N,IRF3,TIRAP,MAPK10,UBE2V1,IRF7,PPP2CB,TICAM1,DHX9,MEF2A,HMGB1,TRAF6,DUSP3,TICAM2,TLR2,IKBKB,UBE2D1,BIRC2,MYD88,CD14,UBE2D3,SARM1,RPS27A
R-HSA-5632684	Hedgehog 'on' state	0.0001011162858635	-9.19923935822941	86	44	0.0136265097553422	3229	10285	57154,51684,2622,8405,5707,5690,1452,5687,79577,8452,5700,5718,5702,5682,6233,84455,5710,5721,5692,9861,7979,5698,5685,5686,5699,122706,5705,5694,5683,5691,5695,5709,5689,64399,5684,5693,5704,10213,7311,7314,5716,5720,339745,5713	SMURF1,SUFU,GAS8,SPOP,PSMD1,PSMB2,CSNK1A1,PSMA6,CDC73,CUL3,PSMC1,PSMD12,PSMC3,PSMA1,RPS27A,EFCAB7,PSMD4,PSME2,PSMB4,PSMD6,SEM1,PSMB9,PSMA4,PSMA5,PSMB10,PSMB11,PSMC5,PSMB6,PSMA2,PSMB3,PSMB7,PSMD3,PSMB1,HHIP,PSMA3,PSMB5,PSMC4,PSMD14,UBA52,UBB,PSMD10,PSME1,SPOPL,PSMD7
R-HSA-4086400	PCP/CE pathway	0.000104610972793813	-9.16526210940881	96	48	0.0148652833694642	3229	10285	1175,57154,5687,50855,1173,5690,5707,1856,5579,5700,8323,5718,5682,5702,100126338,5710,7976,6233,5692,9861,5721,5880,7979,5698,5686,5699,5705,122706,5685,5691,5683,160,5694,5689,5695,5709,5704,5684,5693,23002,10213,7314,5578,7311,5720,5716,8322,5713	AP2S1,SMURF1,PSMA6,PARD6A,AP2M1,PSMB2,PSMD1,DVL2,PRKCB,PSMC1,FZD6,PSMD12,PSMA1,PSMC3,MIR937,PSMD4,FZD3,RPS27A,PSMB4,PSMD6,PSME2,RAC2,SEM1,PSMB9,PSMA5,PSMB10,PSMC5,PSMB11,PSMA4,PSMB3,PSMA2,AP2A1,PSMB6,PSMB1,PSMB7,PSMD3,PSMC4,PSMA3,PSMB5,DAAM1,PSMD14,UBB,PRKCA,UBA52,PSME1,PSMD10,FZD4,PSMD7
R-HSA-72187	mRNA 3'-end processing	0.000105762655248383	-9.15431307581842	62	34	0.0105295757200372	3229	10285	65109,26097,57187,55110,84321,1479,84271,10569,22916,10914,100126351,7919,29894,84248,9775,10212,51362,10189,6426,9785,22794,693221,6432,6427,9877,53981,10978,6429,4116,79228,10898,9984,23283,100302196	UPF3B,CHTOP,THOC2,MAGOHB,THOC3,CSTF3,POLDIP3,SLU7,NCBP2,PAPOLA,MIR939,DDX39B,CPSF1,FYTTD1,EIF4A3,DDX39A,CDC40,ALYREF,SRSF1,DHX38,CASC3,MIR636,SRSF7,SRSF2,ZC3H11A,CPSF2,CLP1,SRSF4,MAGOH,THOC6,CPSF4,THOC1,CSTF2T,MIR1234
R-HSA-68882	Mitotic Anaphase	0.000113772330737445	-9.08131120522498	179	80	0.0247754722824404	3229	10285	5682,5702,348235,5710,79003,4001,51529,5501,6233,9861,29882,25906,5692,8697,79019,7321,5721,9232,29945,91687,5698,619553,83540,7979,3796,401541,5516,57122,4085,7514,5687,5707,5690,22919,80776,79023,5718,5700,10403,119504,6396,5885,10213,7314,7443,5518,246184,7311,4000,5720,79980,5716,5713,5048,122706,5705,5699,5686,8815,147841,5685,5691,5683,5694,7112,5529,9184,991,5689,54820,220134,8881,5709,5695,5704,5525,5693,5684,332,23592	PSMA1,PSMC3,SKA2,PSMD4,MIS12,LMNB1,ANAPC11,PPP1CC,RPS27A,PSMD6,ANAPC2,ANAPC15,PSMB4,CDC23,CENPM,UBE2D1,PSME2,PTTG1,ANAPC4,CENPL,PSMB9,MIR484,NUF2,SEM1,KIF2A,CENPP,PPP2CB,NUP107,MAD2L1,XPO1,PSMA6,PSMD1,PSMB2,MAPRE1,B9D2,NUP37,PSMD12,PSMC1,NDC80,ANAPC16,SEC13,RAD21,PSMD14,UBB,VRK1,PPP2R1A,CDC26,UBA52,LMNA,PSME1,DSN1,PSMD10,PSMD7,PAFAH1B1,PSMB11,PSMC5,PSMB10,PSMA5,BANF1,SPC24,PSMA4,PSMB3,PSMA2,PSMB6,TMPO,PPP2R5E,BUB3,CDC20,PSMB1,NDE1,SKA1,CDC16,PSMD3,PSMB7,PSMC4,PPP2R5A,PSMB5,PSMA3,BIRC5,LEMD3
R-HSA-168898	Toll-Like Receptors Cascades	0.000124951098876407	-8.98758810619291	153	70	0.0216785382471353	3229	10285	5781,5604,1508,4208,57162,5518,246330,7314,81793,7099,7311,6500,5775,948,29110,4792,5606,7096,51284,7100,23643,51311,3725,177,6279,51135,4790,1785,10010,54106,23291,2002,1385,1848,6285,10333,10454,2353,7323,6233,23098,1845,1513,7189,3146,329,7321,3551,7097,353376,4615,7184,929,3665,7335,148022,5516,1660,10695,4205,7867,7098,5608,23118,466,4793,7334,5602,114609,3661	PTPN11,MAP2K1,CTSB,MEF2C,PELI1,PPP2R1A,PELI3,UBB,TLR10,TLR4,UBA52,SKP1,PTPN4,CD36,TBK1,NFKBIA,MAP2K3,TLR1,TLR7,TLR5,LY96,TLR8,JUN,AGER,S100A8,IRAK4,NFKB1,DNM2,TANK,TLR9,FBXW11,ELK1,CREB1,DUSP6,S100B,TLR6,TAB1,FOS,UBE2D3,RPS27A,SARM1,DUSP3,CTSK,TRAF6,HMGB1,BIRC2,UBE2D1,IKBKB,TLR2,TICAM2,MYD88,HSP90B1,CD14,IRF7,UBE2V1,TICAM1,PPP2CB,DHX9,CNPY3,MEF2A,MAPKAPK3,TLR3,MAP2K6,TAB2,ATF1,NFKBIB,UBE2N,MAPK10,TIRAP,IRF3
R-HSA-392518	Signal amplification	0.000134632624695874	-8.91296078753906	33	21	0.0065035614741406	3229	10285	2767,2785,2773,2782,64805,51764,59345,9630,2790,2788,2787,5028,2791,2776,54331,2771,55970,2784,2793,6714,406974	GNA11,GNG3,GNAI3,GNB1,P2RY12,GNG13,GNB4,GNA14,GNG10,GNG7,GNG5,P2RY1,GNG11,GNAQ,GNG2,GNAI2,GNG12,GNB3,GNGT2,SRC,MIR197
R-HSA-5628897	TP53 Regulates Metabolic Genes	0.000139690586737467	-8.8760806759511	82	42	0.0130071229482812	3229	10285	1351,7532,83667,7296,28956,5728,7295,2810,208,10670,1327,51204,10000,207,7001,9377,143686,6009,8649,2877,1353,2539,5052,7529,55004,54541,5571,1340,7157,84987,10325,51241,4697,1349,7533,57690,26523,116228,1345,4343,5564,7534	COX8A,YWHAG,SESN2,TXNRD1,LAMTOR2,PTEN,TXN,SFN,AKT2,RRAGA,COX4I1,TACO1,AKT3,AKT1,PRDX2,COX5A,SESN3,RHEB,LAMTOR3,GPX2,COX11,G6PD,PRDX1,YWHAB,LAMTOR1,DDIT4,PRKAG1,COX6B1,TP53,COX14,RRAGB,COX16,NDUFA4,COX7B,YWHAH,TNRC6C,AGO1,COX20,COX6C,MOV10,PRKAB1,YWHAZ
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.000142624567049986	-8.85529478536956	180	80	0.0247754722824404	3229	10285	7514,5687,4085,57122,5690,5707,22919,401541,3796,5516,5718,5700,10403,119504,79023,80776,5710,4001,79003,51529,5501,6233,5682,5702,348235,9232,29945,91687,619553,5698,7979,83540,29882,9861,8697,5692,25906,79019,5721,7321,5691,5694,5683,9184,5529,7112,5705,122706,5699,5686,8815,5685,147841,5525,5704,5693,5684,23592,332,991,5689,54820,220134,5709,8881,5695,7314,7443,5518,7311,4000,246184,6396,5885,10213,5713,5048,5720,5716,79980	XPO1,PSMA6,MAD2L1,NUP107,PSMB2,PSMD1,MAPRE1,CENPP,KIF2A,PPP2CB,PSMD12,PSMC1,NDC80,ANAPC16,NUP37,B9D2,PSMD4,LMNB1,MIS12,ANAPC11,PPP1CC,RPS27A,PSMA1,PSMC3,SKA2,PTTG1,ANAPC4,CENPL,MIR484,PSMB9,SEM1,NUF2,ANAPC2,PSMD6,CDC23,PSMB4,ANAPC15,CENPM,PSME2,UBE2D1,PSMB3,PSMB6,PSMA2,BUB3,PPP2R5E,TMPO,PSMC5,PSMB11,PSMB10,PSMA5,BANF1,PSMA4,SPC24,PPP2R5A,PSMC4,PSMB5,PSMA3,LEMD3,BIRC5,CDC20,PSMB1,NDE1,SKA1,PSMD3,CDC16,PSMB7,UBB,VRK1,PPP2R1A,UBA52,LMNA,CDC26,SEC13,RAD21,PSMD14,PSMD7,PAFAH1B1,PSME1,PSMD10,DSN1
R-HSA-5419276	Mitochondrial translation termination	0.000143010813430455	-8.8525903121685	87	44	0.0136265097553422	3229	10285	51081,51649,51650,84340,740,64963,6150,51021,64432,51258,65993,60488,64949,57129,64965,122704,28973,9553,64979,64975,54534,51373,124995,28957,64981,55052,78988,79590,55168,54460,116540,65003,64976,29093,29074,118487,54998,92259,51023,65005,6182,54948,28998,63875	MRPS7,MRPS23,MRPS33,GFM2,MRPL49,MRPS11,MRPL23,MRPS16,MRPS25,MRPL51,MRPS34,MRPS35,MRPS26,MRPL47,MRPS9,MRPL52,MRPS18B,MRPL33,MRPL36,MRPL41,MRPL50,MRPS17,MRPL10,MRPS28,MRPL34,MRPL20,MRPL57,MRPL24,MRPS18A,MRPS21,MRPL53,MRPL11,MRPL40,MRPL22,MRPL18,CHCHD1,AURKAIP1,KGD4,MRPS18C,MRPL9,MRPL12,MRPL16,MRPL13,MRPL17
R-HSA-381119	Unfolded Protein Response (UPR)	0.000144596147642641	-8.84156589007001	92	46	0.0142458965624032	3229	10285	3309,1965,2931,51010,468,7184,10113,9570,2673,467,4801,23480,6464,9695,6745,7494,100137049,1649,118,6734,167227,29927,811,6818,55738,10106,10130,3576,84447,4000,58477,7095,51013,10897,4800,55176,10952,7709,11231,11340,30827,6347,4189,54512,5611,55033	HSPA5,EIF2S1,GSK3A,EXOSC3,ATF4,HSP90B1,PREB,GOSR2,GFPT1,ATF3,NFYB,SEC61G,SHC1,EDEM1,SSR1,XBP1,PLA2G4B,DDIT3,ADD1,SRPRA,DCP2,SEC61A1,CALR,SULT1A3,ARFGAP1,CTDSP2,PDIA6,CXCL8,SYVN1,LMNA,SRPRB,SEC62,EXOSC1,YIF1A,NFYA,SEC61A2,SEC61B,ZBTB17,SEC63,EXOSC8,CXXC1,CCL2,DNAJB9,EXOSC4,DNAJC3,FKBP14
R-HSA-611105	Respiratory electron transport	0.000144596147642641	-8.84156589007001	92	46	0.0142458965624032	3229	10285	116228,7385,6391,1340,7384,55863,4712,84987,51241,27089,4718,10975,2109,4697,4726,4710,91942,4698,4729,51204,1327,9377,4706,55967,4728,51300,4722,4694,6390,1345,137682,4695,80219,29078,1349,7388,2108,1353,4711,4714,1351,1537,4716,4720,25915,4713	COX20,UQCRC2,SDHC,COX6B1,UQCRC1,TMEM126B,NDUFB6,COX14,COX16,UQCRQ,NDUFC2,UQCR11,ETFB,NDUFA4,NDUFS6,NDUFB4,NDUFAF2,NDUFA5,NDUFV2,TACO1,COX4I1,COX5A,NDUFAB1,NDUFA12,NDUFS8,TIMMDC1,NDUFS3,NDUFA1,SDHB,COX6C,NDUFAF6,NDUFA2,COQ10B,NDUFAF4,COX7B,UQCRH,ETFA,COX11,NDUFB5,NDUFB8,COX8A,CYC1,NDUFB10,NDUFS2,NDUFAF3,NDUFB7
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.000144663287072206	-8.84110167405689	97	48	0.0148652833694642	3229	10285	6500,5606,51284,4792,4208,5604,7099,7311,57162,5518,7314,246330,2002,1385,10454,2353,6285,1848,51135,4790,23643,51311,177,3725,54106,23291,3551,353376,1845,7189,3146,929,4615,6233,23118,466,4793,7867,7098,5608,5602,7334,148022,5516,3665,7335,4205,1660	SKP1,MAP2K3,TLR7,NFKBIA,MEF2C,MAP2K1,TLR4,UBA52,PELI1,PPP2R1A,UBB,PELI3,ELK1,CREB1,TAB1,FOS,S100B,DUSP6,IRAK4,NFKB1,LY96,TLR8,AGER,JUN,TLR9,FBXW11,IKBKB,TICAM2,DUSP3,TRAF6,HMGB1,CD14,MYD88,RPS27A,TAB2,ATF1,NFKBIB,MAPKAPK3,TLR3,MAP2K6,MAPK10,UBE2N,TICAM1,PPP2CB,IRF7,UBE2V1,MEF2A,DHX9
R-HSA-180786	Extension of Telomeres	0.000147546364629642	-8.82136809510561	31	20	0.0061938680706101	3229	10285	10856,5111,2237,54107,7015,5558,6118,5984,5425,57804,5985,55651,5982,6119,5983,23649,1736,55135,56655,8607	RUVBL2,PCNA,FEN1,POLE3,TERT,PRIM2,RPA2,RFC4,POLD2,POLD4,RFC5,NHP2,RFC2,RPA3,RFC3,POLA2,DKC1,WRAP53,POLE4,RUVBL1
R-HSA-5654738	Signaling by FGFR2	0.000157924586001096	-8.75339294267355	75	39	0.0120780427376897	3229	10285	8823,5295,2252,3185,2246,7072,2549,3265,5516,5432,8074,2962,5438,5290,10817,2248,9982,6464,83888,6714,3178,2255,8822,5431,22916,5435,5436,5781,23543,3845,2963,6233,5433,7311,27006,5441,5518,867,7314	FGF16,PIK3R1,FGF7,HNRNPF,FGF1,TIA1,GAB1,HRAS,PPP2CB,POLR2C,FGF23,GTF2F1,POLR2I,PIK3CA,FRS3,FGF3,FGFBP1,SHC1,FGFBP2,SRC,HNRNPA1,FGF10,FGF17,POLR2B,NCBP2,POLR2F,POLR2G,PTPN11,RBFOX2,KRAS,GTF2F2,RPS27A,POLR2D,UBA52,FGF22,POLR2L,PPP2R1A,CBL,UBB
R-HSA-202040	G-protein activation	0.000160113386458449	-8.73962832834987	29	19	0.00588417466707959	3229	10285	51764,2782,4988,2785,2773,2791,2787,2775,59345,2788,2790,2771,55970,54331,2781,5173,406974,2793,2784	GNG13,GNB1,OPRM1,GNG3,GNAI3,GNG11,GNG5,GNAO1,GNB4,GNG7,GNG10,GNAI2,GNG12,GNG2,GNAZ,PDYN,MIR197,GNGT2,GNB3
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.000168172514154343	-8.690520235465	85	43	0.0133168163518117	3229	10285	5982,86,57804,60,6613,902,64708,5425,6118,8554,1022,4331,1069,54107,283899,2966,7311,10038,7314,9318,10987,8607,56655,2071,7334,7336,3980,2968,7341,125476,50813,6119,6612,5985,7329,5983,5111,5887,6233,404672,51138,5984,29844	RFC2,ACTL6A,POLD4,ACTB,SUMO2,CCNH,COPS7B,POLD2,RPA2,PIAS1,CDK7,MNAT1,CETN2,POLE3,INO80E,GTF2H2,UBA52,PARP2,UBB,COPS2,COPS5,RUVBL1,POLE4,ERCC3,UBE2N,UBE2V2,LIG3,GTF2H4,SUMO1,INO80C,COPS7A,RPA3,SUMO3,RFC5,UBE2I,RFC3,PCNA,RAD23B,RPS27A,GTF2H5,COPS4,RFC4,TFPT
R-HSA-5688426	Deubiquitination	0.000171254031103879	-8.67236254180626	301	124	0.0384019820377826	3229	10285	29844,890,8345,5887,255626,9804,8331,9146,80351,5698,91833,79589,9861,7189,7321,5721,329,125476,4086,51651,7416,4738,5718,7128,1080,10600,9099,4609,8607,9929,10474,3013,7314,55777,6478,10213,5713,85236,23770,64135,5720,9958,9101,8970,7417,8658,5683,5694,5705,122706,5699,5423,8348,4087,5685,5704,5684,5693,154,991,8314,86,5689,5709,5695,5710,367,81847,6233,7186,5682,8334,7157,5702,9960,8335,7353,23586,7979,672,8078,5692,114548,5687,5707,5690,79594,8678,11047,8329,57559,5700,8724,4089,29086,8975,84749,7048,57506,7311,4088,6881,283899,2033,3416,4792,56957,5716,5691,92815,8342,5686,5728,9868,27430,9097,7347,123228,10617,4193,221613,60,10454,9986	TFPT,CCNA2,H2BC9,RAD23B,H2BC1,TOMM20,H2AC14,HGS,TNKS2,PSMB9,WDR20,RNF128,PSMD6,TRAF6,UBE2D1,PSME2,BIRC2,INO80C,SMAD1,PTRH2,VDAC1,NEDD8,PSMD12,TNFAIP3,CFTR,USP16,USP2,MYC,RUVBL1,JOSD1,TADA3,H2AC7,UBB,MBD5,SIAH2,PSMD14,PSMD7,H2BC12,FKBP8,IFIH1,PSME1,USP15,USP8,H2BC11,VDAC2,TNKS,PSMA2,PSMB6,PSMC5,PSMB11,PSMB10,POLB,H2BC17,SMAD2,PSMA4,PSMC4,PSMA3,PSMB5,ADRB2,CDC20,BAP1,ACTL6A,PSMB1,PSMD3,PSMB7,PSMD4,AR,RNF146,RPS27A,TRAF2,PSMA1,H2AC6,TP53,PSMC3,USP3,H2AC4,UFD1,RIGI,SEM1,BRCA1,USP5,PSMB4,NLRP3,PSMA6,PSMD1,PSMB2,MUL1,BECN1,ADRM1,H2AC13,STAMBPL1,PSMC1,SNX3,SMAD4,BABAM1,USP13,USP30,TGFBR2,MAVS,UBA52,SMAD3,TAF10,INO80E,EP300,IDE,NFKBIA,OTUD7B,PSMD10,PSMB3,H2AC25,H2BC14,PSMA5,PTEN,TOMM70,MAT2B,USP14,UCHL3,SENP8,STAMBP,MDM2,H2AC1,ACTB,TAB1,RCE1
R-HSA-937072	TRAF6 mediated induction of TAK1 complex	0.000171428716949696	-8.67134302237063	17	13	0.00402601424589656	3229	10285	148022,23643,23098,6233,7311,7099,7314,23118,353376,7098,7189,929,10454	TICAM1,LY96,SARM1,RPS27A,UBA52,TLR4,UBB,TAB2,TICAM2,TLR3,TRAF6,CD14,TAB1
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	0.000181225242493941	-8.61576986669606	25	17	0.00526478786001858	3229	10285	2790,2788,9630,59345,2776,2791,2787,5028,2785,2767,51764,2782,6714,2793,2784,54331,55970	GNG10,GNG7,GNA14,GNB4,GNAQ,GNG11,GNG5,P2RY1,GNG3,GNA11,GNG13,GNB1,SRC,GNGT2,GNB3,GNG2,GNG12
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	0.000187629558997965	-8.58104096984901	23	16	0.00495509445648808	3229	10285	2773,2785,2782,64805,51764,59345,2788,2790,2787,2791,54331,55970,2771,2784,2793,406974	GNAI3,GNG3,GNB1,P2RY12,GNG13,GNB4,GNG7,GNG10,GNG5,GNG11,GNG2,GNG12,GNAI2,GNB3,GNGT2,MIR197
R-HSA-156590	Glutathione conjugation	0.000195420503449212	-8.5403568932094	38	23	0.00712294828120161	3229	10285	9446,4258,119391,2950,2938,373156,2729,2948,55748,2949,2098,494143,2686,10327,2941,2939,2952,27306,79017,4259,2946,2947,653689	GSTO1,MGST2,GSTO2,GSTP1,GSTA1,GSTK1,GCLC,GSTM4,CNDP2,GSTM5,ESD,CHAC2,GGT7,AKR1A1,GSTA4,GSTA2,GSTT1,HPGDS,GGCT,MGST3,GSTM2,GSTM3,GSTT2B
R-HSA-3700989	Transcriptional Regulation by TP53	0.000218155201464793	-8.43030381515476	367	147	0.0455249303189842	3229	10285	604,1351,28956,5516,5432,79837,2968,10419,27166,10000,207,1025,11073,4848,8649,5608,6882,5571,2071,1387,6749,28984,7157,355,6880,6233,404672,1349,5932,246175,5810,672,4683,1345,64769,9219,5325,5564,83667,7296,29883,8738,902,5728,116028,1327,9377,1874,143686,51755,133383,5982,5931,5052,7529,332,9540,4193,8445,1647,6879,6881,5436,6827,581,84987,2963,9656,7311,5876,6917,57060,7533,57690,90809,124446,116228,4331,4343,6873,2033,5371,5431,7534,7532,208,2962,5928,10670,5438,1353,2539,1026,55004,3622,9099,665,891,8851,5111,1457,94241,10325,5984,890,7029,53615,6119,8550,5985,9337,84289,5983,6829,5366,57472,7295,3725,2810,1020,51204,80196,7001,6118,6009,1460,2877,80010,2353,54541,1027,1340,5435,6921,6794,2966,51241,5433,5441,5518,7832,7314,4697,26523,3486,983,1022	BCL6,COX8A,LAMTOR2,PPP2CB,POLR2C,PIP4K2C,GTF2H4,PRMT5,PRELID1,AKT3,AKT1,CDK9,TOPBP1,CNOT2,LAMTOR3,MAP2K6,TAF11,PRKAG1,ERCC3,CREBBP,SSRP1,RGCC,TP53,FAS,TAF9,RPS27A,GTF2H5,COX7B,RBBP8,CNOT6L,RAD1,BRCA1,NBN,COX6C,MEAF6,MTA2,PLAGL1,PRKAB1,SESN2,TXNRD1,CNOT7,CRADD,CCNH,PTEN,RMI2,COX4I1,COX5A,E2F4,SESN3,CDK12,SETD9,RFC2,RBBP7,PRDX1,YWHAB,BIRC5,TP53I3,MDM2,DYRK2,GADD45A,TAF7,TAF10,POLR2G,SUPT4H1,BAX,COX14,GTF2F2,MDC1,UBA52,RABGGTB,TCEA1,PCBP4,YWHAH,TNRC6C,PIP4P1,TMEM219,COX20,MNAT1,MOV10,TAF2,EP300,PML,POLR2B,YWHAZ,YWHAG,AKT2,GTF2F1,RBBP4,RRAGA,POLR2I,COX11,G6PD,CDKN1A,LAMTOR1,ING2,USP2,BNIP3L,CCNB1,CDK5R1,PCNA,CSNK2A1,TP53INP1,RRAGB,RFC4,CCNA2,TFDP2,MBD3,RPA3,MAPKAPK5,RFC5,CNOT8,ING5,RFC3,SUPT5H,PMAIP1,CNOT6,TXN,JUN,SFN,CDK5,TACO1,RNF34,PRDX2,RPA2,RHEB,CSNK2B,GPX2,RMI1,FOS,DDIT4,CDKN1B,COX6B1,POLR2F,ELOC,STK11,GTF2H2,COX16,POLR2D,POLR2L,PPP2R1A,BTG2,UBB,NDUFA4,AGO1,IGFBP3,CDK1,CDK7
R-HSA-69481	G2/M Checkpoints	0.000239972614579902	-8.33498574704993	169	75	0.0232270052647879	3229	10285	5704,5001,5684,5693,80010,7529,5689,5982,5709,5695,8970,5691,6118,8342,4175,5694,5683,9025,116028,5705,122706,2810,5686,5699,8348,4173,5685,5713,85236,7534,983,5720,5716,7314,7533,7311,9656,10213,891,5718,5700,7334,29086,11073,84515,5687,7341,5690,5707,7336,3014,8317,7532,5983,5698,672,4683,7979,5985,9861,5692,23594,6119,5721,5810,5710,4172,5932,5984,8345,6233,255626,5682,7157,5702	PSMC4,ORC5,PSMA3,PSMB5,RMI1,YWHAB,PSMB1,RFC2,PSMD3,PSMB7,H2BC11,PSMB3,RPA2,H2BC14,MCM6,PSMB6,PSMA2,RNF8,RMI2,PSMC5,PSMB11,SFN,PSMA5,PSMB10,H2BC17,MCM4,PSMA4,PSMD7,H2BC12,YWHAZ,CDK1,PSME1,PSMD10,UBB,YWHAH,UBA52,MDC1,PSMD14,CCNB1,PSMD12,PSMC1,UBE2N,BABAM1,TOPBP1,MCM8,PSMA6,SUMO1,PSMB2,PSMD1,UBE2V2,H2AX,CDC7,YWHAG,RFC3,PSMB9,BRCA1,NBN,SEM1,RFC5,PSMD6,PSMB4,ORC6,RPA3,PSME2,RAD1,PSMD4,MCM3,RBBP8,RFC4,H2BC9,RPS27A,H2BC1,PSMA1,TP53,PSMC3
R-HSA-5368287	Mitochondrial translation	0.000273752312999455	-8.20328682755618	94	46	0.0142458965624032	3229	10285	54998,51023,85476,29093,118487,65005,54948,28998,78988,116540,55168,65003,57129,28973,54534,9553,64975,55052,28957,51649,51650,6150,740,64949,92259,29074,7284,6182,63875,79590,54460,64976,122704,64965,51373,64979,64981,124995,51081,51021,64963,84340,60488,64432,51258,65993	AURKAIP1,MRPS18C,GFM1,MRPL22,CHCHD1,MRPL9,MRPL16,MRPL13,MRPL57,MRPL53,MRPS18A,MRPL11,MRPL47,MRPS18B,MRPL50,MRPL33,MRPL41,MRPL20,MRPS28,MRPS23,MRPS33,MRPL23,MRPL49,MRPS26,KGD4,MRPL18,TUFM,MRPL12,MRPL17,MRPL24,MRPS21,MRPL40,MRPL52,MRPS9,MRPS17,MRPL36,MRPL34,MRPL10,MRPS7,MRPS16,MRPS11,GFM2,MRPS35,MRPS25,MRPL51,MRPS34
R-HSA-190236	Signaling by FGFR	0.000276580576594381	-8.19300836320081	89	44	0.0136265097553422	3229	10285	8823,2252,7072,5516,2549,3265,5432,2962,5438,5290,23768,6464,2248,9982,83888,200734,23767,3178,22916,23543,6233,161742,5295,3185,2246,8074,2260,10817,6714,2255,8822,5431,5435,3845,5781,5436,2963,27006,5441,5433,7311,867,5518,7314	FGF16,FGF7,TIA1,PPP2CB,GAB1,HRAS,POLR2C,GTF2F1,POLR2I,PIK3CA,FLRT2,SHC1,FGF3,FGFBP1,FGFBP2,SPRED2,FLRT3,HNRNPA1,NCBP2,RBFOX2,RPS27A,SPRED1,PIK3R1,HNRNPF,FGF1,FGF23,FGFR1,FRS3,SRC,FGF10,FGF17,POLR2B,POLR2F,KRAS,PTPN11,POLR2G,GTF2F2,FGF22,POLR2L,POLR2D,UBA52,CBL,PPP2R1A,UBB
R-HSA-5696398	Nucleotide Excision Repair	0.000286706186586262	-8.15705260670204	112	53	0.0164137503871168	3229	10285	8554,1022,4331,2033,5431,1069,54107,283899,5435,5436,2966,5433,7311,5441,6917,10038,7314,9318,5982,86,57804,60,6613,902,64708,5425,27339,6118,6119,6612,5985,7329,5983,5111,6233,5887,404672,51138,5984,29844,10987,8607,56655,2071,7334,7336,5432,3980,2968,5438,7341,125476,50813	PIAS1,CDK7,MNAT1,EP300,POLR2B,CETN2,POLE3,INO80E,POLR2F,POLR2G,GTF2H2,POLR2D,UBA52,POLR2L,TCEA1,PARP2,UBB,COPS2,RFC2,ACTL6A,POLD4,ACTB,SUMO2,CCNH,COPS7B,POLD2,PRPF19,RPA2,RPA3,SUMO3,RFC5,UBE2I,RFC3,PCNA,RPS27A,RAD23B,GTF2H5,COPS4,RFC4,TFPT,COPS5,RUVBL1,POLE4,ERCC3,UBE2N,UBE2V2,POLR2C,LIG3,GTF2H4,POLR2I,SUMO1,INO80C,COPS7A
R-HSA-5368286	Mitochondrial translation initiation	0.000325350809428377	-8.03060654415677	87	43	0.0133168163518117	3229	10285	64949,6150,740,51649,51650,55052,28957,54534,64975,9553,28973,57129,65003,116540,55168,78988,28998,54948,65005,51023,54998,29093,118487,60488,65993,51258,64432,51021,64963,51081,64981,124995,51373,64979,122704,64965,64976,54460,79590,63875,6182,92259,29074	MRPS26,MRPL23,MRPL49,MRPS23,MRPS33,MRPL20,MRPS28,MRPL50,MRPL41,MRPL33,MRPS18B,MRPL47,MRPL11,MRPL53,MRPS18A,MRPL57,MRPL13,MRPL16,MRPL9,MRPS18C,AURKAIP1,MRPL22,CHCHD1,MRPS35,MRPS34,MRPL51,MRPS25,MRPS16,MRPS11,MRPS7,MRPL34,MRPL10,MRPS17,MRPL36,MRPL52,MRPS9,MRPL40,MRPS21,MRPL24,MRPL17,MRPL12,KGD4,MRPL18
R-HSA-2467813	Separation of Sister Chromatids	0.000346807404748544	-7.96674096164643	168	74	0.0229173118612574	3229	10285	5682,5702,348235,79003,5710,51529,5501,6233,29882,9861,25906,5692,8697,79019,5721,7321,9232,29945,91687,5698,619553,83540,7979,3796,401541,5516,57122,4085,7514,5687,5707,5690,22919,80776,79023,5718,5700,10403,119504,6396,5885,10213,7314,5518,246184,7311,5720,79980,5716,5713,5048,122706,5705,5699,5686,5685,147841,5691,5683,5694,5529,9184,991,5689,54820,8881,5709,220134,5695,5704,5525,5693,5684,332	PSMA1,PSMC3,SKA2,MIS12,PSMD4,ANAPC11,PPP1CC,RPS27A,ANAPC2,PSMD6,ANAPC15,PSMB4,CDC23,CENPM,PSME2,UBE2D1,PTTG1,ANAPC4,CENPL,PSMB9,MIR484,NUF2,SEM1,KIF2A,CENPP,PPP2CB,NUP107,MAD2L1,XPO1,PSMA6,PSMD1,PSMB2,MAPRE1,B9D2,NUP37,PSMD12,PSMC1,NDC80,ANAPC16,SEC13,RAD21,PSMD14,UBB,PPP2R1A,CDC26,UBA52,PSME1,DSN1,PSMD10,PSMD7,PAFAH1B1,PSMB11,PSMC5,PSMB10,PSMA5,PSMA4,SPC24,PSMB3,PSMA2,PSMB6,PPP2R5E,BUB3,CDC20,PSMB1,NDE1,CDC16,PSMD3,SKA1,PSMB7,PSMC4,PPP2R5A,PSMB5,PSMA3,BIRC5
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.000371084705522277	-7.89908020464551	95	46	0.0142458965624032	3229	10285	948,6500,7096,5606,4792,4208,5604,7311,7099,246330,7314,5518,57162,1385,2002,2353,10454,10333,1848,6285,4790,51135,3725,177,23643,23291,3551,7097,7189,3146,1845,929,4615,6233,4793,466,23118,5608,7867,114609,5602,7334,5516,7335,4205,1660	CD36,SKP1,TLR1,MAP2K3,NFKBIA,MEF2C,MAP2K1,UBA52,TLR4,PELI3,UBB,PPP2R1A,PELI1,CREB1,ELK1,FOS,TAB1,TLR6,DUSP6,S100B,NFKB1,IRAK4,JUN,AGER,LY96,FBXW11,IKBKB,TLR2,TRAF6,HMGB1,DUSP3,CD14,MYD88,RPS27A,NFKBIB,ATF1,TAB2,MAP2K6,MAPKAPK3,TIRAP,MAPK10,UBE2N,PPP2CB,UBE2V1,MEF2A,DHX9
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	0.000371084705522277	-7.89908020464551	95	46	0.0142458965624032	3229	10285	2002,466,23118,4793,1385,7867,5608,114609,10454,5602,2353,7334,10333,1848,6285,51135,4790,5516,23643,3725,7335,177,4205,23291,1660,948,7097,3551,1845,7189,6500,3146,929,5606,7096,4792,4615,4208,5604,6233,7311,7099,5518,57162,7314,246330	ELK1,ATF1,TAB2,NFKBIB,CREB1,MAPKAPK3,MAP2K6,TIRAP,TAB1,MAPK10,FOS,UBE2N,TLR6,DUSP6,S100B,IRAK4,NFKB1,PPP2CB,LY96,JUN,UBE2V1,AGER,MEF2A,FBXW11,DHX9,CD36,TLR2,IKBKB,DUSP3,TRAF6,SKP1,HMGB1,CD14,MAP2K3,TLR1,NFKBIA,MYD88,MEF2C,MAP2K1,RPS27A,UBA52,TLR4,PPP2R1A,PELI1,UBB,PELI3
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.000371084705522277	-7.89908020464551	95	46	0.0142458965624032	3229	10285	6233,3551,7097,1845,7189,3146,929,4615,5516,7335,4205,1660,466,23118,4793,7867,5608,114609,5602,7334,4208,5604,7311,7099,5518,57162,7314,246330,948,6500,5606,7096,4792,51135,4790,23643,177,3725,23291,2002,1385,10454,2353,10333,6285,1848	RPS27A,IKBKB,TLR2,DUSP3,TRAF6,HMGB1,CD14,MYD88,PPP2CB,UBE2V1,MEF2A,DHX9,ATF1,TAB2,NFKBIB,MAPKAPK3,MAP2K6,TIRAP,MAPK10,UBE2N,MEF2C,MAP2K1,UBA52,TLR4,PPP2R1A,PELI1,UBB,PELI3,CD36,SKP1,MAP2K3,TLR1,NFKBIA,IRAK4,NFKB1,LY96,AGER,JUN,FBXW11,ELK1,CREB1,TAB1,FOS,TLR6,S100B,DUSP6
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.000371084705522277	-7.89908020464551	95	46	0.0142458965624032	3229	10285	4790,5516,51135,7335,177,3725,23643,23291,4205,1660,1385,4793,23118,466,2002,5608,7867,2353,5602,10454,114609,6285,1848,10333,7334,4208,5604,7099,7311,6233,7314,246330,57162,5518,948,3551,7097,3146,6500,7189,1845,7096,5606,929,4615,4792	NFKB1,PPP2CB,IRAK4,UBE2V1,AGER,JUN,LY96,FBXW11,MEF2A,DHX9,CREB1,NFKBIB,TAB2,ATF1,ELK1,MAP2K6,MAPKAPK3,FOS,MAPK10,TAB1,TIRAP,S100B,DUSP6,TLR6,UBE2N,MEF2C,MAP2K1,TLR4,UBA52,RPS27A,UBB,PELI3,PELI1,PPP2R1A,CD36,IKBKB,TLR2,HMGB1,SKP1,TRAF6,DUSP3,TLR1,MAP2K3,CD14,MYD88,NFKBIA
R-HSA-381070	IRE1alpha activates chaperones	0.000388785952379053	-7.85248161674303	58	31	0.00960049550944565	3229	10285	55738,4189,55033,5611,10106,29927,6818,30827,118,6734,100137049,7494,11231,7709,10952,55176,6745,2673,9695,6464,23480,7095,10113,9570,10897,2931,84447,10130,58477,3309,4000	ARFGAP1,DNAJB9,FKBP14,DNAJC3,CTDSP2,SEC61A1,SULT1A3,CXXC1,ADD1,SRPRA,PLA2G4B,XBP1,SEC63,ZBTB17,SEC61B,SEC61A2,SSR1,GFPT1,EDEM1,SHC1,SEC61G,SEC62,PREB,GOSR2,YIF1A,GSK3A,SYVN1,PDIA6,SRPRB,HSPA5,LMNA
R-HSA-201451	Signaling by BMP	0.000398930818443937	-7.82672254346629	24	16	0.00495509445648808	3229	10285	658,9350,4089,4093,657,7321,9241,64388,659,4086,11167,4090,7323,91851,57154,406975	BMPR1B,CER1,SMAD4,SMAD9,BMPR1A,UBE2D1,NOG,GREM2,BMPR2,SMAD1,FSTL1,SMAD5,UBE2D3,CHRDL1,SMURF1,MIR198
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.000422878059865935	-7.76842669502571	16	12	0.00371632084236606	3229	10285	23118,353376,7098,7189,10454,929,148022,23643,6233,7311,7099,7314	TAB2,TICAM2,TLR3,TRAF6,TAB1,CD14,TICAM1,LY96,RPS27A,UBA52,TLR4,UBB
R-HSA-5683057	MAPK family signaling cascades	0.000434597174265111	-7.74109099208413	290	118	0.0365438216165996	3229	10285	10817,5716,1852,6714,4343,2255,5908,3845,5604,84292,27006,7311,57690,5894,3561,7529,998,2246,5525,1848,152559,4233,5686,8074,5529,6709,5037,5691,6464,25780,5692,5062,7979,896,1843,5702,5682,6233,3562,10602,5245,5710,161742,8823,8649,818,3560,7450,8452,5700,3567,5516,3815,28956,3265,5690,5707,3315,8682,5687,5896,26523,5536,6711,5720,284,983,8822,5713,10213,5781,5567,5518,10642,7314,5695,3717,5709,10435,5689,3569,5693,5684,5704,5685,5699,122706,3725,5705,2260,3558,5683,5694,1445,8315,1742,5721,2248,1839,8550,9861,200734,3559,5698,4296,11221,4747,1437,3716,2252,989,4609,5596,5718,53358,7514,5906,3572	FRS3,PSMD10,DUSP9,SRC,MOV10,FGF10,RAP1B,KRAS,MAP2K1,WDR83,FGF22,UBA52,TNRC6C,RAF1,IL2RG,YWHAB,CDC42,FGF1,PPP2R5A,DUSP6,PAQR3,MET,PSMA5,FGF23,PPP2R5E,SPTAN1,PEBP1,PSMB3,SHC1,RASGRP3,PSMB4,PAK2,SEM1,CCND3,DUSP1,PSMC3,PSMA1,RPS27A,IL3,CDC42EP3,PHB1,PSMD4,SPRED1,FGF16,LAMTOR3,CAMK2G,IL2RB,VWF,CUL3,PSMC1,IL5,PPP2CB,KIT,LAMTOR2,HRAS,PSMB2,PSMD1,HSPB1,PEA15,PSMA6,RAG1,AGO1,PPP5C,SPTBN1,PSME1,ANGPT1,CDK1,FGF17,PSMD7,PSMD14,PTPN11,PRKACB,PPP2R1A,IGF2BP1,UBB,PSMB7,JAK2,PSMD3,CDC42EP2,PSMB1,IL6,PSMB5,PSMA3,PSMC4,PSMA4,PSMB10,PSMB11,JUN,PSMC5,FGFR1,IL2,PSMA2,PSMB6,CSK,BRAP,DLG4,PSME2,FGF3,HBEGF,MAPKAPK5,PSMD6,SPRED2,IL2RA,PSMB9,MAP3K11,DUSP10,NEFL,CSF2,JAK1,FGF7,SEPTIN7,MYC,MAPK4,PSMD12,SHC3,XPO1,RAP1A,IL6ST
R-HSA-5663202	Diseases of signal transduction	0.000435902368731026	-7.73809226461901	369	146	0.0452152369154537	3229	10285	122706,5705,2260,5699,5685,4087,940,8658,1445,8315,5694,5683,5295,10956,5689,1385,5709,3717,5695,1027,5704,5693,57085,5684,7276,5781,10213,51009,5435,84447,7314,6776,867,5518,5441,5433,3516,2280,1487,6500,5664,5720,26127,8322,8805,5713,941,7750,8822,23385,208,5906,1452,6772,5438,2962,1026,8503,10014,5718,4609,2252,2931,4296,572,55750,9861,1839,2248,5721,55294,80351,5698,79885,8074,5686,4233,5037,51107,5691,5529,29851,22943,5296,27248,2246,5525,4193,11044,7529,5604,4088,2963,3845,5436,5908,5894,10533,7048,27006,7311,4000,55109,6714,5716,5431,2033,2255,118788,5432,5516,3815,3265,2549,23493,3320,5290,207,5687,10000,5707,5690,10013,1185,1024,8823,55851,1387,8323,5700,7450,4089,942,5682,5702,1499,5710,5245,11160,6233,5692,6464,22916,4040,8841,7979	PSMB11,PSMC5,FGFR1,PSMB10,PSMA4,SMAD2,CD28,TNKS,CSK,BRAP,PSMB6,PSMA2,PIK3R1,OS9,PSMB1,CREB1,PSMD3,JAK2,PSMB7,CDKN1B,PSMC4,PSMB5,AGTRAP,PSMA3,TTR,PTPN11,PSMD14,DERL2,POLR2F,SYVN1,UBB,STAT5A,CBL,PPP2R1A,POLR2L,POLR2D,RBPJ,FKBP1A,CTBP1,SKP1,PSEN2,PSME1,FGFR1OP2,FZD4,TRIM24,PSMD7,CD80,ZMYM2,FGF17,NCSTN,AKT2,RAP1A,CSNK1A1,STAT1,POLR2I,GTF2F1,CDKN1A,PIK3R3,HDAC5,PSMD12,MYC,FGF7,GSK3A,MAP3K11,BAD,AGK,PSMD6,HBEGF,FGF3,PSME2,FBXW7,TNKS2,PSMB9,HDAC11,FGF23,PSMA5,MET,PEBP1,APH1A,PSMB3,PPP2R5E,ICOS,DKK1,PIK3R2,ERLEC1,FGF1,PPP2R5A,MDM2,TENT4A,YWHAB,MAP2K1,SMAD3,GTF2F2,KRAS,POLR2G,RAP1B,RAF1,ATG7,TGFBR2,FGF22,UBA52,LMNA,AGGF1,SRC,PSMD10,POLR2B,EP300,FGF10,PIK3AP1,POLR2C,PPP2CB,KIT,HRAS,GAB1,HEY2,HSP90AA1,PIK3CA,AKT1,PSMA6,AKT3,PSMD1,PSMB2,HDAC6,CLCN6,CDK8,FGF16,PSENEN,CREBBP,FZD6,PSMC1,VWF,SMAD4,CD86,PSMA1,PSMC3,CTNNB1,PSMD4,PHB1,ERLIN2,RPS27A,PSMB4,SHC1,NCBP2,LRP6,HDAC3,SEM1
R-HSA-418217	G beta:gamma signalling through PLC beta	0.000437246116511854	-7.73501432572455	20	14	0.00433570764942707	3229	10285	2790,2788,2784,59345,2793,2787,23236,2791,2785,54331,5330,55970,2782,51764	GNG10,GNG7,GNB3,GNB4,GNGT2,GNG5,PLCB1,GNG11,GNG3,GNG2,PLCB2,GNG12,GNB1,GNG13
R-HSA-6785807	Interleukin-4 and 13 signaling	0.000441809092560112	-7.72463268647453	111	52	0.0161040569835862	3229	10285	3593,4318,948,595,3596,3312,7124,51561,9655,3576,3662,7076,3586,6657,332,3569,2353,3717,3561,9021,7133,5295,6347,3552,58480,112744,3565,3726,356,4692,7184,598,6356,7422,5008,4988,7157,3553,3716,4609,10538,1278,4170,3606,3592,1026,3383,3320,6772,207,604,6778	IL12B,MMP9,CD36,CCND1,IL13,HSPA8,TNF,IL23A,SOCS5,CXCL8,IRF4,TIMP1,IL10,SOX2,BIRC5,IL6,FOS,JAK2,IL2RG,SOCS3,TNFRSF1B,PIK3R1,CCL2,IL1A,RHOU,IL17F,IL4,JUNB,FASLG,NDN,HSP90B1,BCL2L1,CCL11,VEGFA,OSM,OPRM1,TP53,IL1B,JAK1,MYC,BATF,COL1A2,MCL1,IL18,IL12A,CDKN1A,ICAM1,HSP90AA1,STAT1,AKT1,BCL6,STAT6
R-HSA-381038	XBP1(S) activates chaperone genes	0.000456141883505415	-7.69270664880821	56	30	0.00929080210591514	3229	10285	55738,4189,10106,55033,5611,29927,30827,6818,7494,100137049,6734,118,11231,7709,10952,6745,55176,2673,6464,23480,9695,7095,10897,9570,10113,2931,84447,10130,4000,58477	ARFGAP1,DNAJB9,CTDSP2,FKBP14,DNAJC3,SEC61A1,CXXC1,SULT1A3,XBP1,PLA2G4B,SRPRA,ADD1,SEC63,ZBTB17,SEC61B,SSR1,SEC61A2,GFPT1,SHC1,SEC61G,EDEM1,SEC62,YIF1A,GOSR2,PREB,GSK3A,SYVN1,PDIA6,LMNA,SRPRB
R-HSA-74160	Gene Expression	0.000471097888654234	-7.66044465400419	1821	632	0.195726231031279	3229	10285	11335,5707,24144,6158,207,6625,3320,27166,10419,5432,81605,4089,6629,28984,60559,4435,5608,2146,136991,246175,7913,23521,51493,81875,29115,92856,5682,54960,10436,23478,4683,6634,7919,26097,79050,4116,8449,8342,1874,6134,60487,3726,6188,6146,84135,8894,23536,22794,8445,1647,10421,79027,5052,7728,22826,6129,84172,85437,9656,10526,57690,6917,23451,2963,581,116228,10308,6201,79228,988,2962,7743,79691,29102,1660,27335,55657,8726,3014,11017,79084,57510,6122,10772,3190,79023,56902,5901,8345,10325,55623,5984,9330,56259,9521,8331,84991,6191,154007,51003,6667,9972,5241,5465,6119,283989,10181,5683,5694,6009,80196,27339,26986,7752,6619,5685,6747,3181,693221,5704,51504,8669,5689,80818,3516,5433,5441,171568,6637,55954,4697,10642,10213,1340,5435,11325,29960,55813,100126351,200315,10262,1024,3315,3815,2968,29079,79837,79897,6217,146542,2071,29927,57794,84265,6224,10291,11073,474382,6128,327,6233,1349,5932,6207,23658,7157,6235,2100,8334,10907,7323,84321,7329,84271,1345,672,1964,55840,22916,7422,64769,55703,55110,51503,1977,84944,5691,8666,28987,3184,116028,27043,5686,7529,1665,8467,5876,23398,25942,6879,6881,6606,6155,6628,4088,5436,6827,6727,84246,7534,6873,79871,9031,90809,6159,4736,5438,6626,4605,57122,6152,54482,7101,1915,283337,9970,8856,9879,94115,4609,6161,2197,1974,7586,51691,6432,6427,79042,9775,2539,10248,6839,9439,1353,7458,255626,3178,54514,1937,84289,6618,55174,5721,833,2960,8550,55759,51204,6143,6118,7001,9984,57117,3329,8891,11102,5366,8348,2957,3725,10605,5468,51602,80010,55634,1027,27350,57819,24140,28972,54989,57570,51362,8819,6936,8350,51241,3312,5578,2966,58477,388536,9128,54700,6921,55181,6204,27341,51065,26523,3486,5917,51808,11097,5690,25888,10285,6147,7341,55272,5516,604,4929,60436,57504,79759,2959,6229,1387,114049,5571,5700,1025,10171,10212,8649,404672,3028,5710,11157,1965,6880,8741,6176,23636,1736,6234,8335,190,9219,51637,6138,64859,23480,51605,6184,6193,5810,4141,57187,9329,6638,133383,9377,9877,7296,11340,6429,5728,27258,9540,3185,60,332,2193,3183,51077,57060,5252,7533,6168,6434,84248,84987,10084,6170,4331,10949,4343,1933,6258,5431,5371,10302,6154,1454,5716,124446,10670,84967,79577,10284,6746,6130,7514,7532,55766,208,80349,6734,10127,1975,79760,9099,665,10621,8851,5718,79175,10189,3921,55124,6157,8575,55749,6729,29982,94241,1457,79891,9337,5698,29107,6829,164668,221785,58490,10952,55644,51121,9440,8970,122706,8896,54541,100302240,6160,6136,54512,1460,4853,2877,10762,6203,115939,7314,3735,5518,7832,6205,6187,79101,51082,85236,55781,65109,2961,983,6209,1022,5720,6745,9789,10000,5687,57721,28956,1351,6731,10978,53981,6165,6617,9785,1938,6882,6749,127253,144348,4848,1993,2063,6633,367,140801,355,5702,56006,6635,55197,7979,10438,5325,1653,5564,10914,10713,55651,3188,11103,80153,5692,2107,1655,1327,26121,51755,129450,143686,11224,6139,83667,7421,902,8738,29883,3646,10885,4193,6141,10465,6133,5982,7257,8893,5931,7311,169270,6228,2958,6206,51106,6124,5546,2033,9589,54913,57343,7376,162239,6208,5928,90353,57336,9582,115708,167227,9669,3015,3622,55004,891,23381,143689,3013,79685,1026,94239,129401,79047,9410,23471,53615,7029,890,51639,5111,29894,6175,619279,6218,1479,10569,8892,51010,5983,6231,9271,6132,7321,55696,54487,5985,54974,27042,9861,6181,55176,1020,10898,8125,100302196,23283,57472,4087,6627,6632,7295,5705,2810,5699,5684,90390,5693,2353,23405,8664,58500,83443,407043,113802,25804,5709,5695,5822,3191,6426,51729,10199,30834,6794,51367,10200,5713,51013,6604,6096,7247,9442,11260,9349,9416	CBX3,PSMD1,TFIP11,RPL28,AKT1,SNRNP70,HSP90AA1,PRELID1,PRMT5,POLR2C,URM1,SMAD4,SNRPB2,RGCC,SPCS3,CITED1,MAP2K6,EZH2,ASZ1,CNOT6L,DEK,RPL13A,RTCB,ISG20L2,SAP30BP,IMP4,PSMA1,GEMIN8,EMG1,SEC11A,NBN,SNRPD3,DDX39B,CHTOP,NOC4L,MAGOH,DHX16,H2BC14,E2F4,RPL10,TRMT11,JUNB,RPS3,RPL22,UTP15,EIF2S2,ADAT1,CASC3,DYRK2,GADD45A,CD2BP2,ZNF655,PRDX1,ZNF175,DNAJC8,RPL7,POLR1B,ZCRB1,MDC1,IPO8,TNRC6C,TCEA1,SF3B1,GTF2F2,BAX,COX20,ZNF267,RPS7,THOC6,CDC5L,GTF2F1,ZNF189,QTRT2,DROSHA,DHX9,EIF3K,ZNF692,EED,H2AX,SNRNP27,WDR77,XPO5,RPL3,SRSF10,HNRNPK,NUP37,PNO1,RAN,H2BC9,RRAGB,THUMPD1,RFC4,GTF3C3,CTNNBL1,EEF1E1,H2AC14,RBM17,RPS4X,SNRNP48,MED31,SP1,NUP153,PGR,PPARA,RPA3,TSEN54,RBM5,PSMA2,PSMB6,RHEB,RNF34,PRPF19,PABPC1,ZNF200,SNAPC3,PSMA4,SSR3,HNRNPA2B1,MIR636,PSMC4,TRMT112,EIF3J,PSMB1,ZNF436,RBPJ,POLR2D,POLR2L,POLR3H,SNRPG,ZMAT5,NDUFA4,IGF2BP1,PSMD14,COX6B1,POLR2F,DDX42,MRM2,UTP6,MIR939,APOBEC3A,SF3B4,CDK8,HSPB1,KIT,GTF2H4,MED4,PIP4K2C,RPP21,RPS16,ZNF688,ERCC3,SEC61A1,SUGP1,POLR3GL,RPS20,SF3A1,TOPBP1,H2AB1,RPL6,APEH,RPS27A,COX7B,RBBP8,RPS13,LSM5,TP53,RPS29,ESR2,H2AC6,TXNL4A,UBE2D3,THOC3,UBE2I,POLDIP3,COX6C,BRCA1,EIF1AX,EAF2,NCBP2,VEGFA,MEAF6,POLR3B,MAGOHB,CWC15,EIF4E,MAEL,PSMB3,EIF3G,NOB1,HNRNPD,RMI2,PELP1,PSMA5,YWHAB,DHX15,SMARCA5,RABGGTB,PPWD1,SIN3A,TAF7,TAF10,SMN1,RPL27,SNRPB,SMAD3,POLR2G,SUPT4H1,SRP14,MED10,YWHAZ,TAF2,RPAP2,BAZ1B,PIP4P1,RPL29,RPL10A,POLR2I,SNRPA,MYBL2,NUP107,RPL24,TRMT13,NR2E1,EEF1A1,ZNF740,NR1I3,NR1I2,DDX46,CGB8,MYC,RPL32,FAU,EIF4A2,ZKSCAN1,LSM8,SRSF7,SRSF2,TSEN34,EIF4A3,G6PD,POP7,SUV39H1,MED23,COX11,EIF4H,H2BC1,HNRNPA1,DDX4,EEF1G,ING5,SNAPC2,INTS10,PSME2,CARS1,GTF2E1,MAPKAPK5,WDR12,TACO1,RPL19,RPA2,PRDX2,THOC1,INTS12,HSPD1,EIF2B3,RPP14,PMAIP1,H2BC17,GTF2A1,JUN,PAIP1,PPARG,NOP58,RMI1,KRBOX4,CDKN1B,APOBEC3C,LSM2,FTSJ1,SPCS1,ZNF770,TRMT5,CDC40,SAP30,GCFC2,H3C1,COX16,HSPA8,PRKCA,GTF2H2,SRPRB,ZNF790,PRPF4,RRN3,ELOC,SMG8,RPS10,RRP7A,RPS27L,AGO1,IGFBP3,RARS1,PHAX,NUP42,PSMB2,ZNF473,SMNDC1,RPL23A,SUMO1,IMP3,PPP2CB,BCL6,NR4A2,TGIF2,MTA3,ZNF668,GTF2B,RPS24,CREBBP,BUD23,PRKAG1,PSMC1,CDK9,RCL1,DDX39A,LAMTOR3,GTF2H5,HSD17B10,PSMD4,LSM6,EIF2S1,TAF9,TNFSF13,RPLP1,NUP62,DKC1,RPS28,H2AC4,NR0B1,MTA2,RTRAF,RPL15,NABP1,SEC61G,TRMT6,RPN1,RPS5,RAD1,MARS1,THOC2,GTF3C4,SNRPN,SETD9,COX5A,ZC3H11A,TXNRD1,EXOSC8,SRSF4,PTEN,LSM3,TP53I3,HNRNPF,ACTB,BIRC5,FARSA,HNRNPC,FCF1,PCBP4,PHF1,YWHAH,RPL37A,TRA2B,FYTTD1,COX14,PQBP1,RPL39,MNAT1,HNRNPA0,MOV10,EEF1B2,RXRG,POLR2B,PML,SNAPC5,RPL26,CSNK1E,PSMD10,TMEM219,RRAGA,LSM10,CDC73,SAP18,SSR2,RPL7A,XPO1,YWHAG,H2AJ,AKT2,SKIC8,SRPRA,ZNF263,EIF4B,GEMIN7,USP2,BNIP3L,POLR3F,CDK5R1,PSMD12,ZNF343,ALYREF,RPSA,PIWIL2,RPL27A,PRKRA,CCAR1,SRP54,NRBF2,TP53INP1,CSNK2A1,ZNF671,CNOT8,PSMB9,NXT1,SUPT5H,APOBEC3H,ZSCAN25,RPRD1B,SEC61B,OSGEP,RPL26L1,MED17,H2BC11,PSMB11,BUD31,DDIT4,MIR1304,RPL31,RPL12,EXOSC4,CSNK2B,NOTCH2,GPX2,NUP50,RPS9,TSR3,UBB,KARS1,PPP2R1A,BTG2,RPS11,RPS2,TAF1D,POLR1D,H2BC12,RIOK2,UPF3B,GTF2E2,CDK1,RPS15,CDK7,PSME1,SSR1,SPCS2,AKT3,PSMA6,METTL14,LAMTOR2,COX8A,SRP72,CLP1,CPSF2,RPL35A,SNAPC1,DHX38,EEF2,TAF11,SSRP1,TYW3,ZNF664,CNOT2,ELAVL2,NR2F6,SNRPD2,AR,RPL10L,FAS,PSMC3,SMG9,SNRPE,RPRD1A,SEM1,C1D,PLAGL1,DDX1,PRKAB1,PAPOLA,USP39,NHP2,HNRNPH2,KRR1,EDC3,PSMB4,ETF1,DDX5,COX4I1,PRPF31,CDK12,TYW5,SESN3,RPL35,RPL17,SESN2,VDR,CCNH,CRADD,CNOT7,EIF3E,WDR3,MDM2,RPL18,PPIH,RPL9,RFC2,TSNAX,EIF2B5,RBBP7,UBA52,ZNF596,RPS23,GTF2A2,RPS12,TFB1M,RPL4,PRCC,EP300,WTAP,RPP25,ZNF304,NR1H2,ZFP1,RPS14,RBBP4,CTU1,ZNF287,APOBEC3B,TRMT61A,DCP2,EIF5B,H2AZ1,ING2,LAMTOR1,CCNB1,SMG5,PIWIL4,H2AC7,SAP30L,CDKN1A,H2AZ2,NUP35,KCTD15,SNRNP40,TRAM1,MBD3,TFDP2,CCNA2,SF3B6,PCNA,CPSF1,RPLP0,ZNF704,RPS17,CSTF3,SLU7,EIF2B2,EXOSC3,RFC3,RPS26,PIWIL1,RPL8,UBE2D1,RBM22,DGCR8,RFC5,THG1L,UTP25,PSMD6,RPLP2,SEC61A2,CDK5,CPSF4,ANP32A,MIR1234,CSTF2T,CNOT6,SMAD2,SNRPA1,SNRPD1,TXN,PSMC5,SFN,PSMB10,PSMA3,MED30,PSMB5,FOS,DICER1,EIF3D,ZNF250,SF3B5,MIR7-1,HENMT1,LSM4,PSMD3,PSMB7,PWP2,HNRNPL,SRSF1,WBP11,MPHOSPH10,POLR1H,STK11,POP5,MPHOSPH6,PSMD7,EXOSC1,SMARCD3,RORB,TSN,MED27,XPOT,RPL23,DDX23
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.000562586435802788	-7.48296577204135	47	26	0.00805202849179312	3229	10285	4331,5431,6873,2961,2960,1022,5433,5441,404672,2966,6879,6881,5435,6880,2958,2963,5436,2959,6882,2071,5438,2962,2957,2968,5432,902	MNAT1,POLR2B,TAF2,GTF2E2,GTF2E1,CDK7,POLR2D,POLR2L,GTF2H5,GTF2H2,TAF7,TAF10,POLR2F,TAF9,GTF2A2,GTF2F2,POLR2G,GTF2B,TAF11,ERCC3,POLR2I,GTF2F1,GTF2A1,GTF2H4,POLR2C,CCNH
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.000562586435802788	-7.48296577204135	47	26	0.00805202849179312	3229	10285	5435,6879,6881,5436,6880,2958,2963,2966,5433,5441,404672,2961,2960,1022,4331,6873,5431,2957,902,5432,2968,2962,5438,2959,6882,2071	POLR2F,TAF7,TAF10,POLR2G,TAF9,GTF2A2,GTF2F2,GTF2H2,POLR2D,POLR2L,GTF2H5,GTF2E2,GTF2E1,CDK7,MNAT1,TAF2,POLR2B,GTF2A1,CCNH,POLR2C,GTF2H4,GTF2F1,POLR2I,GTF2B,TAF11,ERCC3
R-HSA-73776	RNA Polymerase II Promoter Escape	0.000562586435802788	-7.48296577204135	47	26	0.00805202849179312	3229	10285	2968,902,5432,2957,5438,2962,2071,6882,2959,2963,2958,6880,5436,6881,6879,5435,5441,404672,5433,2966,1022,2960,2961,5431,6873,4331	GTF2H4,CCNH,POLR2C,GTF2A1,POLR2I,GTF2F1,ERCC3,TAF11,GTF2B,GTF2F2,GTF2A2,TAF9,POLR2G,TAF10,TAF7,POLR2F,POLR2L,GTF2H5,POLR2D,GTF2H2,CDK7,GTF2E1,GTF2E2,POLR2B,TAF2,MNAT1
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.000562586435802788	-7.48296577204135	47	26	0.00805202849179312	3229	10285	2960,1022,2961,6873,5431,4331,5436,6880,2958,2963,5435,6879,6881,2966,5433,5441,404672,2071,2959,6882,5432,902,2968,2957,2962,5438	GTF2E1,CDK7,GTF2E2,TAF2,POLR2B,MNAT1,POLR2G,TAF9,GTF2A2,GTF2F2,POLR2F,TAF7,TAF10,GTF2H2,POLR2D,POLR2L,GTF2H5,ERCC3,GTF2B,TAF11,POLR2C,CCNH,GTF2H4,GTF2A1,GTF2F1,POLR2I
R-HSA-167161	HIV Transcription Initiation	0.000562586435802788	-7.48296577204135	47	26	0.00805202849179312	3229	10285	2962,5438,2957,902,5432,2968,6882,2959,2071,2966,5441,404672,5433,5435,6881,6879,5436,2958,2963,6880,4331,6873,5431,2961,1022,2960	GTF2F1,POLR2I,GTF2A1,CCNH,POLR2C,GTF2H4,TAF11,GTF2B,ERCC3,GTF2H2,POLR2L,GTF2H5,POLR2D,POLR2F,TAF10,TAF7,POLR2G,GTF2A2,GTF2F2,TAF9,MNAT1,TAF2,POLR2B,GTF2E2,CDK7,GTF2E1
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.000562586435802788	-7.48296577204135	47	26	0.00805202849179312	3229	10285	4331,5431,6873,2961,2960,1022,5433,5441,404672,2966,6879,6881,5435,6880,2958,2963,5436,2959,6882,2071,5438,2962,2957,2968,902,5432	MNAT1,POLR2B,TAF2,GTF2E2,GTF2E1,CDK7,POLR2D,POLR2L,GTF2H5,GTF2H2,TAF7,TAF10,POLR2F,TAF9,GTF2A2,GTF2F2,POLR2G,GTF2B,TAF11,ERCC3,POLR2I,GTF2F1,GTF2A1,GTF2H4,CCNH,POLR2C
R-HSA-1433557	Signaling by SCF-KIT	0.000581793418567403	-7.44939512415794	337	134	0.0414989160730876	3229	10285	7157,5702,942,5682,3562,6233,161742,5245,5710,6464,25780,5692,7979,1843,2549,3265,28956,5516,3815,3567,79837,5690,5707,10000,207,8682,5687,5290,8823,3560,8649,818,7450,8452,5700,8870,5908,5604,3845,7311,27006,84292,5894,57690,5716,10817,6714,1852,4343,4318,2255,118788,4233,152559,8074,5686,5728,6709,5529,8394,5691,5037,7525,5296,3561,29851,4193,7529,2887,1848,5525,2246,2931,572,4296,9402,4747,11221,2248,5721,9861,1839,5698,200734,3559,208,53358,5906,6772,8503,1026,1437,2252,3716,5718,10213,10750,5781,5578,7314,5518,867,6776,6711,1215,5536,26523,284,5720,5713,941,8822,5685,5705,2260,3558,122706,5699,5683,5694,940,1742,8315,1445,1385,5709,5695,3717,5295,5689,5684,5693,1027,5704	TP53,PSMC3,CD86,PSMA1,IL3,RPS27A,SPRED1,PHB1,PSMD4,SHC1,RASGRP3,PSMB4,SEM1,DUSP1,GAB1,HRAS,LAMTOR2,PPP2CB,KIT,IL5,PIP4K2C,PSMB2,PSMD1,AKT3,AKT1,PEA15,PSMA6,PIK3CA,FGF16,IL2RB,LAMTOR3,CAMK2G,VWF,CUL3,PSMC1,IER3,RAP1B,MAP2K1,KRAS,UBA52,FGF22,WDR83,RAF1,TNRC6C,PSMD10,FRS3,SRC,DUSP9,MOV10,MMP9,FGF10,PIK3AP1,MET,PAQR3,FGF23,PSMA5,PTEN,SPTAN1,PPP2R5E,PIP5K1A,PSMB3,PEBP1,YES1,PIK3R2,IL2RG,ICOS,MDM2,YWHAB,GRB10,DUSP6,PPP2R5A,FGF1,GSK3A,BAD,MAP3K11,GRAP2,NEFL,DUSP10,FGF3,PSME2,PSMD6,HBEGF,PSMB9,SPRED2,IL2RA,AKT2,SHC3,RAP1A,STAT1,PIK3R3,CDKN1A,CSF2,FGF7,JAK1,PSMD12,PSMD14,GRAP,PTPN11,PRKCA,UBB,PPP2R1A,CBL,STAT5A,SPTBN1,CMA1,PPP5C,AGO1,ANGPT1,PSME1,PSMD7,CD80,FGF17,PSMA4,PSMC5,FGFR1,IL2,PSMB11,PSMB10,PSMA2,PSMB6,CD28,DLG4,BRAP,CSK,CREB1,PSMD3,PSMB7,JAK2,PIK3R1,PSMB1,PSMA3,PSMB5,CDKN1B,PSMC4
R-HSA-72086	mRNA Capping	0.000633966581323731	-7.36351431576216	29	18	0.00557448126354909	3229	10285	5435,902,5432,5436,2968,2963,2962,2966,5433,404672,5438,5441,1022,4331,2071,6829,5431,22916	POLR2F,CCNH,POLR2C,POLR2G,GTF2H4,GTF2F2,GTF2F1,GTF2H2,POLR2D,GTF2H5,POLR2I,POLR2L,CDK7,MNAT1,ERCC3,SUPT5H,POLR2B,NCBP2
R-HSA-6798695	Neutrophil degranulation	0.000653184922903178	-7.33365027903396	487	186	0.0576029730566739	3229	10285	1075,7305,94103,567,4973,6279,2919,7276,2950,8560,5709,11026,51316,5695,3920,5611,8907,10857,3312,64114,10159,5713,10875,23385,25798,1992,79980,5906,10043,54918,22875,4311,3074,5878,1915,9545,55004,56729,5223,2204,5476,51719,4758,23593,11031,3577,961,6282,9861,80331,326624,8836,8778,10576,5686,2207,391,1727,6590,5864,6616,2171,10533,11240,1508,25852,4860,5908,5478,6727,23412,55754,51209,9342,7130,28956,5834,1116,57826,823,3240,2665,1938,11333,23406,5547,327,10549,54472,5702,5236,22931,2683,9145,51382,8904,929,3146,5870,25801,353376,1471,5683,25840,29099,820,5912,7133,5689,1460,8773,4282,5265,51806,5663,5873,10213,3608,5269,3043,10694,29108,5718,55832,684,7520,2512,8635,58485,10396,51125,23197,3728,967,8655,6709,5273,10097,12,4790,10075,84418,6402,2212,3326,8987,1774,10577,4718,8673,80301,965,51552,258010,3163,6093,4318,2495,3958,6386,2268,4831,948,3320,5707,203068,11010,6836,51646,5049,966,9588,10120,175,6515,1509,374395,8649,1476,3685,10383,374403,2040,3417,4069,7097	CTSC,TYROBP,ORMDL3,B2M,OLR1,S100A8,CXCL1,TTR,GSTP1,DEGS1,PSMD3,LILRA3,PLAC8,PSMB7,LAMP2,DNAJC3,AP1M1,PGRMC1,HSPA8,TMBIM1,ATP6AP2,PSMD7,FGL2,NCSTN,BRI3,SERPINB1,DSN1,RAP1A,TOM1,CMTM6,ENPP4,MME,HEXB,RAB5C,EEF1A1,RAB3D,LAMTOR1,RETN,PGAM1,FCAR,CTSA,CAB39,NEU1,HEBP2,RAB31,CXCR1,CD47,S100A11,PSMD6,DNAJC5,RAB37,GGH,SIGLEC5,CCT2,PSMA5,FCER1G,RHOG,CYB5R3,SLPI,RAB3A,SNAP25,FABP5,ATG7,PADI2,CTSB,ARMC8,PNP,RAP1B,PPIA,SRP14,COMMD3,TMEM30A,RAB9B,SNAP29,TNFAIP6,LAMTOR2,PYGB,CHI3L1,RAP2C,CAPN1,HP,GDI2,EEF2,PDAP1,COTL1,PRCP,APEH,PRDX4,TOLLIP,PSMC3,PGM1,RAB18,B4GALT1,SYNGR1,ATP6V1D,CPNE1,CD14,HMGB1,RAB6A,GCA,TICAM2,CST3,PSMA2,TMT1A,COMMD9,CAMP,RAP2B,TNFRSF1B,PSMB1,CSNK2B,SNAP23,MIF,SERPINA1,CALML5,PSEN1,RAB27A,PSMD14,ILF2,SERPINB6,HBB,CCT8,PYCARD,PSMD12,CAND1,BST2,XRCC5,FTL,RNASET2,TRAPPC1,ATP8A1,GOLGA7,FAF2,JUP,CD63,DYNLL1,SPTAN1,SERPINB10,ACTR2,SERPINA3,NFKB1,HUWE1,CYSTM1,SELL,FCGR2A,HSP90AB1,STBD1,DNASE1L1,NPC2,NDUFC2,VAMP8,PLEKHO2,CD58,RAB14,SVIP,HMOX2,ROCK1,MMP9,FTH1,LGALS3,SDCBP,FGR,NME2,CD36,HSP90AA1,PSMD1,TUBB,GLIPR1,SURF4,YPEL5,PAFAH1B2,CD59,PRDX6,ACTR1B,AGA,SLC2A3,CTSD,TMEM179B,LAMTOR3,CSTB,ITGAV,TUBB4B,TBC1D10C,STOM,IDH1,LYZ,TLR2
R-HSA-449147	Signaling by Interleukins	0.000673429762625384	-7.30312685467109	525	199	0.0616289873025705	3229	10285	3627,2248,7189,3559,5698,4296,3553,1437,3716,1278,5718,3383,53358,3572,5896,6711,5720,284,3662,10213,5781,57162,6776,7124,5518,7314,3717,5689,7133,6347,1399,1230,6657,3569,5704,5685,6364,122706,2260,5694,5683,112744,3565,25780,3551,6464,598,6356,5682,5008,3562,5710,4988,5245,23118,3606,8649,5608,1234,8452,5700,729230,604,5516,3265,6778,7335,5707,5690,3320,5290,8682,207,53833,6348,5716,948,595,3596,4318,3845,5604,27006,6850,51561,5894,246330,5296,3561,9021,332,10454,2246,1848,152559,51135,3726,4790,4233,3552,6709,3600,5721,1839,9861,7184,200734,4215,4615,11221,8878,4747,920,1026,8503,2252,4609,10538,6772,5906,5536,6500,3593,8822,941,5713,7076,10068,7850,3312,867,9655,3576,5695,3636,5709,8350,6363,5295,2353,2919,5684,5693,5699,4692,3558,5705,58480,23291,1445,8315,50616,1742,5692,7979,7422,1843,5702,7157,54472,942,6233,3556,161742,4170,8823,3592,818,3560,7450,7334,3567,28956,3815,146433,3601,5687,3574,10817,1852,6714,2255,7534,5908,3586,84292,1271,7311,7529,6804,6352,5525,356,5686,8074,5529,7525,5037,5691	CXCL10,FGF3,TRAF6,IL2RA,PSMB9,MAP3K11,IL1B,CSF2,JAK1,COL1A2,PSMD12,ICAM1,SHC3,IL6ST,RAG1,SPTBN1,PSME1,ANGPT1,IRF4,PSMD14,PTPN11,PELI1,STAT5A,TNF,PPP2R1A,UBB,JAK2,PSMB1,TNFRSF1B,CCL2,CRKL,CCR1,SOX2,IL6,PSMC4,PSMA4,CCL20,PSMB11,FGFR1,PSMB6,PSMA2,IL17F,IL4,RASGRP3,IKBKB,SHC1,BCL2L1,CCL11,PSMA1,OSM,IL3,PSMD4,OPRM1,PHB1,TAB2,IL18,LAMTOR3,MAP2K6,CCR5,CUL3,PSMC1,CCR2,BCL6,PPP2CB,HRAS,STAT6,UBE2V1,PSMD1,PSMB2,HSP90AA1,PIK3CA,PEA15,AKT1,IL20RB,CCL3,PSMD10,CD36,CCND1,IL13,MMP9,KRAS,MAP2K1,FGF22,SYK,IL23A,RAF1,PELI3,PIK3R2,IL2RG,SOCS3,BIRC5,TAB1,FGF1,DUSP6,PAQR3,IRAK4,JUNB,NFKB1,MET,IL1A,SPTAN1,IL15,PSME2,HBEGF,PSMD6,HSP90B1,SPRED2,MAP3K3,MYD88,DUSP10,SQSTM1,NEFL,CD4,CDKN1A,PIK3R3,FGF7,MYC,BATF,STAT1,RAP1A,PPP5C,SKP1,IL12B,FGF17,CD80,PSMD7,TIMP1,IL18BP,IL1R2,HSPA8,CBL,SOCS5,CXCL8,PSMB7,INPPL1,PSMD3,H3C1,CCL19,PIK3R1,FOS,CXCL1,PSMA3,PSMB5,PSMB10,NDN,IL2,PSMC5,RHOU,FBXW11,CSK,BRAP,IL22,DLG4,PSMB4,SEM1,VEGFA,DUSP1,PSMC3,TP53,TOLLIP,CD86,RPS27A,IL1RAP,SPRED1,MCL1,FGF16,IL12A,CAMK2G,IL2RB,VWF,UBE2N,IL5,LAMTOR2,KIT,IL34,IL15RA,PSMA6,IL7,FRS3,DUSP9,SRC,FGF10,YWHAZ,RAP1B,IL10,WDR83,CNTFR,UBA52,YWHAB,STX1A,CCL5,PPP2R5A,FASLG,PSMA5,FGF23,PPP2R5E,YES1,PEBP1,PSMB3
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.000708826528732914	-7.25189973170321	27	17	0.00526478786001858	3229	10285	902,5436,5432,2963,2968,5435,2966,2962,5441,5438,404672,5433,1022,6829,2071,5431,4331	CCNH,POLR2G,POLR2C,GTF2F2,GTF2H4,POLR2F,GTF2H2,GTF2F1,POLR2L,POLR2I,GTF2H5,POLR2D,CDK7,SUPT5H,ERCC3,POLR2B,MNAT1
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	0.000708826528732914	-7.25189973170321	27	17	0.00526478786001858	3229	10285	2071,6829,5431,4331,1022,2962,2966,5433,5438,404672,5441,5436,5432,902,2968,2963,5435	ERCC3,SUPT5H,POLR2B,MNAT1,CDK7,GTF2F1,GTF2H2,POLR2D,POLR2I,GTF2H5,POLR2L,POLR2G,POLR2C,CCNH,GTF2H4,GTF2F2,POLR2F
R-HSA-8852135	Protein ubiquitination	0.000709610648762099	-7.25079412037054	62	32	0.00991018891297615	3229	10285	7334,7347,9810,51255,8915,90268,220441,3093,79577,8970,8342,10670,10477,7328,80349,55284,8348,85236,7320,8078,7321,7314,6233,8345,7311,7323,27338,255626,7319,7327,7332,56254	UBE2N,UCHL3,RNF40,RNF181,BCL10,OTULIN,RNF152,UBE2K,CDC73,H2BC11,H2BC14,RRAGA,UBE2E3,UBE2H,SKIC8,UBE2W,H2BC17,H2BC12,UBE2B,USP5,UBE2D1,UBB,RPS27A,H2BC9,UBA52,UBE2D3,UBE2S,H2BC1,UBE2A,UBE2G2,UBE2L3,RNF20
R-HSA-2424491	DAP12 signaling	0.000762970894525162	-7.1782906735081	356	140	0.0433570764942707	3229	10285	8823,8649,818,3560,7450,8870,5700,8452,3567,5516,28956,3815,3265,2549,79837,5707,5690,5290,10000,8682,207,5687,6464,25780,5692,7979,3822,1843,5702,7157,5682,942,6233,3562,5710,5245,161742,3561,5296,29851,7529,4193,2246,5525,1848,152559,4233,5728,5686,8074,5529,8394,6709,5136,5037,5691,10817,5716,1852,6714,4343,118788,2255,5908,3845,5604,84292,27006,6850,7311,5894,57690,1437,5581,1026,8503,3716,2252,5718,208,53358,5906,5721,2248,1839,9861,200734,3559,5698,4296,572,2931,9402,11221,4747,3717,5695,1385,5709,10768,5689,5295,7410,109,5693,5684,5704,1027,5685,3824,567,5699,122706,2260,3558,5705,7305,108,5683,5694,1445,8315,1742,940,26523,5536,6711,5153,5720,284,941,8822,5713,10213,5781,5567,5578,5518,7314,3937	FGF16,LAMTOR3,CAMK2G,IL2RB,VWF,IER3,PSMC1,CUL3,IL5,PPP2CB,LAMTOR2,KIT,HRAS,GAB1,PIP4K2C,PSMD1,PSMB2,PIK3CA,AKT3,PEA15,AKT1,PSMA6,SHC1,RASGRP3,PSMB4,SEM1,KLRC2,DUSP1,PSMC3,TP53,PSMA1,CD86,RPS27A,IL3,PSMD4,PHB1,SPRED1,IL2RG,PIK3R2,ICOS,YWHAB,MDM2,FGF1,PPP2R5A,DUSP6,PAQR3,MET,PTEN,PSMA5,FGF23,PPP2R5E,PIP5K1A,SPTAN1,PDE1A,PEBP1,PSMB3,FRS3,PSMD10,DUSP9,SRC,MOV10,PIK3AP1,FGF10,RAP1B,KRAS,MAP2K1,WDR83,FGF22,SYK,UBA52,RAF1,TNRC6C,CSF2,PRKCE,CDKN1A,PIK3R3,JAK1,FGF7,PSMD12,AKT2,SHC3,RAP1A,PSME2,FGF3,HBEGF,PSMD6,SPRED2,IL2RA,PSMB9,MAP3K11,BAD,GSK3A,GRAP2,DUSP10,NEFL,JAK2,PSMB7,CREB1,PSMD3,AHCYL1,PSMB1,PIK3R1,VAV2,ADCY3,PSMB5,PSMA3,PSMC4,CDKN1B,PSMA4,KLRD1,B2M,PSMB10,PSMB11,FGFR1,IL2,PSMC5,TYROBP,ADCY2,PSMA2,PSMB6,CSK,BRAP,DLG4,CD28,AGO1,PPP5C,SPTBN1,PDE1B,PSME1,ANGPT1,CD80,FGF17,PSMD7,PSMD14,PTPN11,PRKACB,PRKCA,PPP2R1A,UBB,LCP2
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.000785962953482678	-7.14860089961955	25	16	0.00495509445648808	3229	10285	9184,6233,246184,7311,51529,4085,7314,119504,4751,29945,7321,8881,8697,25906,991,29882	BUB3,RPS27A,CDC26,UBA52,ANAPC11,MAD2L1,UBB,ANAPC16,NEK2,ANAPC4,UBE2D1,CDC16,CDC23,ANAPC15,CDC20,ANAPC2
R-HSA-948021	Transport to the Golgi and subsequent modification	0.000818995418201674	-7.1074320685082	164	71	0.0219882316506658	3229	10285	51693,8703,10282,6396,51014,9331,11316,5265,51399,6811,9382,9527,6711,10175,4253,10652,9486,10905,23423,11258,8774,100313843,51128,23256,372,6709,1075,51164,375,27095,81876,5861,11070,8775,2530,2890,55014,1781,4245,11014,6480,79090,8655,3998,11282,122553,3972,10671,10484,51272,9570,10113,26984,10945,10342,2683,9554,11320,54732,51226,966,26286,7109,8702,58485,9117,55738,1780,378,6484,2348	TRAPPC2L,B4GALT3,BET1,SEC13,TMED7,B4GALT6,COPE,SERPINA1,TRAPPC4,STX5,COG1,GOSR1,SPTBN1,CNIH1,MIA2,YKT6,CHST10,MAN1A2,TMED3,DCTN3,NAPG,MIR711,SAR1B,SCFD1,ARCN1,SPTAN1,CTSC,DCTN4,ARF1,TRAPPC3,RAB1B,RAB1A,TMEM115,NAPA,FUT8,GRIA1,STX17,DYNC1I2,MGAT1,KDELR2,ST6GAL1,TRAPPC6A,DYNLL1,LMAN1,MGAT4B,TRAPPC6B,LHB,DCTN6,SEC23A,BET1L,GOSR2,PREB,SEC22A,KDELR1,TFG,B4GALT1,SEC22B,MGAT4A,TMED9,COPZ2,CD59,ARFGAP3,TRAPPC10,B4GALT4,TRAPPC1,SEC22C,ARFGAP1,DYNC1I1,ARF4,ST3GAL4,FOLR1
R-HSA-428930	Thromboxane signalling through TP receptor	0.000862294625719681	-7.05591355252028	23	15	0.00464540105295757	3229	10285	54331,55970,2784,2793,2785,2767,2782,51764,2790,2788,9630,59345,2787,2776,2791	GNG2,GNG12,GNB3,GNGT2,GNG3,GNA11,GNB1,GNG13,GNG10,GNG7,GNA14,GNB4,GNG5,GNAQ,GNG11
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.000862294625719681	-7.05591355252028	23	15	0.00464540105295757	3229	10285	119504,29945,891,7321,8881,8697,25906,991,983,29882,6233,246184,7311,51529,7314	ANAPC16,ANAPC4,CCNB1,UBE2D1,CDC16,CDC23,ANAPC15,CDC20,CDK1,ANAPC2,RPS27A,CDC26,UBA52,ANAPC11,UBB
R-HSA-500657	Presynaptic function of Kainate receptors	0.00093305028996709	-6.97705145721148	21	14	0.00433570764942707	3229	10285	2790,2788,59345,2793,2784,23236,2791,2787,54331,2785,5330,51764,55970,2782	GNG10,GNG7,GNB4,GNGT2,GNB3,PLCB1,GNG11,GNG5,GNG2,GNG3,PLCB2,GNG13,GNG12,GNB1
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.00093305028996709	-6.97705145721148	21	14	0.00433570764942707	3229	10285	56655,5983,6119,5982,5985,57804,5425,5984,6118,2237,54107,328,5111,5423	POLE4,RFC3,RPA3,RFC2,RFC5,POLD4,POLD2,RFC4,RPA2,FEN1,POLE3,APEX1,PCNA,POLB
R-HSA-5336415	Uptake and function of diphtheria toxin	0.000954547134979559	-6.9542735341638	6	6	0.00185816042118303	3229	10285	3320,1839,3326,7296,928,1938	HSP90AA1,HBEGF,HSP90AB1,TXNRD1,CD9,EEF2
R-HSA-451326	Activation of Kainate Receptors upon glutamate binding	0.0009806490715387	-6.92729588763872	32	19	0.00588417466707959	3229	10285	83988,59345,2788,2790,2787,2791,23236,5330,2785,1742,2897,2782,51764,1739,1741,2793,2784,54331,55970	NCALD,GNB4,GNG7,GNG10,GNG5,GNG11,PLCB1,PLCB2,GNG3,DLG4,GRIK1,GNB1,GNG13,DLG1,DLG3,GNGT2,GNB3,GNG2,GNG12
R-HSA-888590	GABA synthesis, release, reuptake and degradation	0.000991133070523138	-6.91666175361446	19	13	0.00402601424589656	3229	10285	6538,140679,10815,6844,3312,80331,6812,6616,5864,2572,6529,6804,6539	SLC6A11,SLC32A1,CPLX1,VAMP2,HSPA8,DNAJC5,STXBP1,SNAP25,RAB3A,GAD2,SLC6A1,STX1A,SLC6A12
R-HSA-69278	Cell Cycle, Mitotic	0.000998582283458052	-6.90917400143502	514	194	0.0600805202849179	3229	10285	29945,9232,26003,83540,7979,95681,10121,5692,51529,1163,5558,4001,6233,5501,8334,5702,7157,7846,474382,8636,84515,5687,10000,5048,1069,2033,7311,6396,51053,1781,5525,80321,23592,5982,5691,5529,902,5686,5983,51343,5985,9861,29882,5721,7321,79019,890,79003,7029,129401,1031,255626,348235,5111,23649,891,3015,4609,56655,94239,63943,1026,64785,3013,57122,4605,22919,5928,1859,10776,5713,6500,79980,23194,10051,5578,246184,5001,1027,1032,5684,5693,8350,5695,5709,6118,7112,5425,23291,5699,5705,147841,8348,8815,91687,896,8335,10383,23636,619553,8697,23594,5710,4172,5682,5700,10403,54892,80776,4085,3320,207,79648,203068,5690,5707,11097,3796,8317,55142,5516,4331,84296,595,5716,1454,5500,7443,4659,4000,5885,54107,332,4751,54820,57804,3326,1874,8342,4149,9972,5698,25906,6119,10133,5862,5984,7298,91754,8345,1457,8655,8331,5718,119504,5579,79023,1021,7514,208,401541,55766,7532,2237,3014,85236,5720,1022,983,5518,7314,10213,5925,140609,5704,7283,1019,10762,5689,5861,81876,991,8881,1460,220134,8970,9184,5683,5694,4175,122706,4173,5685,11258	ANAPC4,PTTG1,GORASP2,NUF2,SEM1,CEP41,ACTR1A,PSMB4,ANAPC11,CKS1B,PRIM2,LMNB1,RPS27A,PPP1CC,H2AC6,PSMC3,TP53,TUBA1A,H2AB1,SSNA1,MCM8,PSMA6,AKT3,PAFAH1B1,CETN2,EP300,UBA52,SEC13,GMNN,DYNC1I2,PPP2R5A,CEP70,LEMD3,RFC2,PSMB3,PPP2R5E,CCNH,PSMA5,RFC3,FZR1,RFC5,PSMD6,ANAPC2,PSME2,UBE2D1,CENPM,CCNA2,MIS12,TFDP2,NUP35,CDKN2C,H2BC1,SKA2,PCNA,POLA2,CCNB1,H2AZ1,MYC,POLE4,H2AZ2,FKBPL,CDKN1A,GINS3,H2AC7,NUP107,MYBL2,MAPRE1,RBBP4,DYRK1A,ARPP19,PSMD7,SKP1,DSN1,FBXL7,SMC4,PRKCA,CDC26,ORC5,CDKN1B,CDKN2D,PSMA3,PSMB5,H3C1,PSMB7,PSMD3,RPA2,TMPO,POLD2,FBXW11,PSMB10,PSMC5,SPC24,H2BC17,BANF1,CENPL,CCND3,H2AC4,TUBB4B,NUP62,MIR484,CDC23,ORC6,PSMD4,MCM3,PSMA1,PSMC1,NDC80,NCAPG2,B9D2,MAD2L1,HSP90AA1,AKT1,MCPH1,TUBB,PSMB2,PSMD1,NUP42,KIF2A,CDC7,HAUS2,PPP2CB,MNAT1,GINS4,CCND1,PSMD10,CSNK1E,PPP1CB,VRK1,PPP1R12A,LMNA,RAD21,POLE3,BIRC5,NEK2,NDE1,POLD4,HSP90AB1,E2F4,H2BC14,MAX,NUP153,PSMB9,ANAPC15,RPA3,OPTN,RAB2A,RFC4,TYMS,NEK9,H2BC9,CSNK2A1,DYNLL1,H2AC14,PSMD12,ANAPC16,PRKCB,NUP37,CDK6,XPO1,AKT2,CENPP,H2AJ,YWHAG,FEN1,H2AX,H2BC12,PSME1,CDK7,CDK1,PPP2R1A,UBB,PSMD14,RB1,NEK7,PSMC4,TUBG1,CDK4,NUP50,PSMB1,RAB1A,RAB1B,CDC20,CDC16,CSNK2B,SKA1,H2BC11,BUB3,PSMA2,PSMB6,MCM6,PSMB11,MCM4,PSMA4,DCTN3
R-HSA-446652	Interleukin-1 signaling	0.00101340194110887	-6.89444234948235	46	25	0.00774233508826262	3229	10285	5604,3553,54472,7850,7314,246330,8878,57162,7311,3556,6233,7189,6500,3551,4615,4215,7335,4790,51135,23291,3552,5608,23118,7334,10454	MAP2K1,IL1B,TOLLIP,IL1R2,UBB,PELI3,SQSTM1,PELI1,UBA52,IL1RAP,RPS27A,TRAF6,SKP1,IKBKB,MYD88,MAP3K3,UBE2V1,NFKB1,IRAK4,FBXW11,IL1A,MAP2K6,TAB2,UBE2N,TAB1
R-HSA-69275	G2/M Transition	0.00113577009089122	-6.7804443639446	182	77	0.0238463920718489	3229	10285	5682,8655,7157,5702,10133,890,5710,6233,5692,9861,5721,10383,7979,95681,619553,10121,5698,55142,7532,5516,7514,5687,3320,4605,203068,22919,5928,5690,5707,63943,1026,8636,5700,891,5718,7846,10213,5518,7314,5500,7311,4659,5720,983,1022,6500,23194,5716,1454,5048,2033,5713,1069,4331,902,5699,5686,5705,122706,5685,11258,5691,5683,5694,23291,54820,5689,5695,3326,5709,7283,5704,1781,80321,5693,5684,4751	PSMA1,DYNLL1,TP53,PSMC3,OPTN,CCNA2,PSMD4,RPS27A,PSMB4,PSMD6,PSME2,TUBB4B,SEM1,CEP41,MIR484,ACTR1A,PSMB9,HAUS2,YWHAG,PPP2CB,XPO1,PSMA6,HSP90AA1,MYBL2,TUBB,MAPRE1,RBBP4,PSMB2,PSMD1,FKBPL,CDKN1A,SSNA1,PSMC1,CCNB1,PSMD12,TUBA1A,PSMD14,PPP2R1A,UBB,PPP1CB,UBA52,PPP1R12A,PSME1,CDK1,CDK7,SKP1,FBXL7,PSMD10,CSNK1E,PAFAH1B1,EP300,PSMD7,CETN2,MNAT1,CCNH,PSMB10,PSMA5,PSMC5,PSMB11,PSMA4,DCTN3,PSMB3,PSMA2,PSMB6,FBXW11,NDE1,PSMB1,PSMB7,HSP90AB1,PSMD3,TUBG1,PSMC4,DYNC1I2,CEP70,PSMB5,PSMA3,NEK2
R-HSA-199991	Membrane Trafficking	0.0012606005974241	-6.67616700696494	610	226	0.0699907091978941	3229	10285	51534,27183,9342,7109,51209,10000,6845,10094,11345,2665,378,9371,134829,57186,27131,29763,51762,5868,3998,6233,9363,79571,80006,10484,2590,5870,22931,5564,9950,11021,51128,23256,160,2017,51164,375,27095,5864,51560,11070,7529,2890,1781,7037,4646,8301,55770,6396,55763,5050,7311,6714,51542,23557,84694,9341,5048,7534,1175,29127,90196,5867,5878,127833,1173,25977,9117,10987,7164,920,115548,9827,4738,3949,4943,8906,64837,54662,4619,11031,81631,51138,27243,8677,10671,2706,60561,6643,25978,1785,8774,100313843,6869,2810,1075,11337,23216,11014,10749,9882,10282,3312,2589,23299,2697,4952,51399,867,9318,9382,8907,53407,9527,55707,8322,10652,8766,23423,9230,5049,966,7251,6836,3796,5872,7018,207,9266,50813,6844,1856,55738,1780,388552,5571,5898,2348,8905,79090,10109,79961,55850,116442,10981,122553,2705,83452,10113,9570,10945,374403,9525,9554,10097,9267,372,6709,51510,3797,79735,382,112574,10640,57465,8675,122830,51552,149371,10052,51014,11316,8673,10228,7533,9712,4253,10175,27348,157807,27128,2495,54732,7532,51226,60560,7163,208,26286,414918,58485,8976,2512,51160,27314,1080,8655,29988,10133,51272,125058,26984,22836,92421,4620,10342,9146,11258,64708,8773,81876,154,917,5861,8775,55014,51693,5873,5265,9367,6811,7314,9892,6711,84251,10905,11336	VTA1,VPS4A,SNAP29,TRAPPC10,RAB9B,AKT3,VAMP7,ARPC3,GABARAPL2,GDI2,ARF4,KIF3B,CLVS2,RALGAPA2,SNX5,PACSIN3,RAB8B,RAB5A,LMAN1,RPS27A,RAB33A,GCC1,TRAPPC13,SEC23A,GALNT2,RAB6A,RAB18,PRKAB1,GOLGA5,RAB35,SAR1B,SCFD1,AP2A1,CTTN,DCTN4,ARF1,TRAPPC3,RAB3A,RAB6B,TMEM115,YWHAB,GRIA1,DYNC1I2,TFRC,MYO6,PICALM,EXOC2,SEC13,EXOC1,PAFAH1B3,UBA52,SRC,VPS54,SNAPIN,GJA10,VAMP3,PAFAH1B1,YWHAZ,AP2S1,RACGAP1,SYS1,RAB4A,RAB5C,SYT2,AP2M1,NECAP1,SEC22C,COPS5,TPD52L1,CD4,FCHO2,RGP1,NEDD8,LDLR,TBC1D25,AP1G2,KLC2,TBC1D13,MYH1,RAB31,MAP1LC3B,COPS4,CHMP2A,STX10,DCTN6,GJB2,RINT1,SNX2,CHMP2B,DNM2,NAPG,MIR711,TACR1,SFN,CTSC,GABARAP,TBC1D1,KDELR2,KIF1C,TBC1D4,BET1,HSPA8,GALNT1,BICD2,GJA1,OCRL,TRAPPC4,CBL,COPS2,COG1,AP1M1,STX18,GOSR1,NECAP2,FZD4,YKT6,RAB11A,TMED3,RAB11B,PAFAH1B2,CD59,TSG101,SURF4,KIF2A,RAB13,TF,AKT1,CYTH2,COPS7A,VAMP2,DVL2,ARFGAP1,DYNC1I1,BLOC1S3,PRKAG1,RALA,FOLR1,AP1S2,TRAPPC6A,ARPC2,DENND2D,USE1,RAB39B,RAB32,TRAPPC6B,GJB1,RAB33B,PREB,GOSR2,KDELR1,TBC1D10C,VPS4B,SEC22B,ACTR2,CYTH1,ARCN1,SPTAN1,CHMP5,KIF3C,TBC1D17,ARF6,SNX18,EXOC5,TBC1D24,STX16,NAA30,RAB14,EXOC8,GJC1,TMED7,COPE,VAMP8,STX6,YWHAH,USP6NL,MIA2,CNIH1,TOR1B,CLVS1,CYTH4,FTH1,TMED9,YWHAG,COPZ2,NAA35,TPD52,AKT2,ARFGAP3,DENND6B,TRAPPC1,WASL,FTL,VPS28,RAB30,CFTR,DYNLL1,SLC2A8,OPTN,BET1L,TBC1D16,SEC22A,RHOBTB3,CHMP4C,MYH2,TFG,HGS,DCTN3,COPS7B,SNAP23,RAB1B,ADRB2,CD3G,RAB1A,NAPA,STX17,TRAPPC2L,RAB27A,SERPINA1,RAB9A,STX5,UBB,SNAP91,SPTBN1,SGIP1,MAN1A2,EXOC3
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.00131139625527623	-6.6366628656549	84	40	0.0123877361412202	3229	10285	1845,6500,3146,7189,3551,4792,4615,5606,5604,4208,5518,57162,246330,7314,6233,7311,81793,7867,5608,2002,466,23118,4793,1385,7334,6285,1848,10454,5602,2353,7100,7335,177,3725,51135,4790,5516,1660,4205,23291	DUSP3,SKP1,HMGB1,TRAF6,IKBKB,NFKBIA,MYD88,MAP2K3,MAP2K1,MEF2C,PPP2R1A,PELI1,PELI3,UBB,RPS27A,UBA52,TLR10,MAPKAPK3,MAP2K6,ELK1,ATF1,TAB2,NFKBIB,CREB1,UBE2N,S100B,DUSP6,TAB1,MAPK10,FOS,TLR5,UBE2V1,AGER,JUN,IRAK4,NFKB1,PPP2CB,DHX9,MEF2A,FBXW11
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.00131139625527623	-6.6366628656549	84	40	0.0123877361412202	3229	10285	7867,5608,23118,2002,466,1385,4793,7334,1848,6285,5602,10454,2353,7100,177,3725,7335,51135,5516,4790,1660,4205,23291,1845,3146,6500,7189,3551,4615,4792,5606,5604,4208,57162,5518,246330,7314,6233,81793,7311	MAPKAPK3,MAP2K6,TAB2,ELK1,ATF1,CREB1,NFKBIB,UBE2N,DUSP6,S100B,MAPK10,TAB1,FOS,TLR5,AGER,JUN,UBE2V1,IRAK4,PPP2CB,NFKB1,DHX9,MEF2A,FBXW11,DUSP3,HMGB1,SKP1,TRAF6,IKBKB,MYD88,NFKBIA,MAP2K3,MAP2K1,MEF2C,PELI1,PPP2R1A,PELI3,UBB,RPS27A,TLR10,UBA52
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.00131139625527623	-6.6366628656549	84	40	0.0123877361412202	3229	10285	7867,5608,2002,466,23118,4793,1385,7334,6285,1848,10454,5602,2353,7100,7335,3725,177,51135,4790,5516,1660,4205,23291,1845,3146,6500,7189,3551,4792,4615,5606,5604,4208,5518,57162,7314,246330,6233,7311,81793	MAPKAPK3,MAP2K6,ELK1,ATF1,TAB2,NFKBIB,CREB1,UBE2N,S100B,DUSP6,TAB1,MAPK10,FOS,TLR5,UBE2V1,JUN,AGER,IRAK4,NFKB1,PPP2CB,DHX9,MEF2A,FBXW11,DUSP3,HMGB1,SKP1,TRAF6,IKBKB,NFKBIA,MYD88,MAP2K3,MAP2K1,MEF2C,PPP2R1A,PELI1,UBB,PELI3,RPS27A,UBA52,TLR10
R-HSA-114604	GPVI-mediated activation cascade	0.0013678250548182	-6.59453335186445	54	28	0.00867141529885413	3229	10285	3937,3562,6850,5781,80739,5880,3559,6464,10000,5294,207,5290,3558,208,3567,2207,388,391,998,7410,3716,1437,8503,5295,3560,3717,5296,3561	LCP2,IL3,SYK,PTPN11,MPIG6B,RAC2,IL2RA,SHC1,AKT3,PIK3CG,AKT1,PIK3CA,IL2,AKT2,IL5,FCER1G,RHOB,RHOG,CDC42,VAV2,JAK1,CSF2,PIK3R3,PIK3R1,IL2RB,JAK2,PIK3R2,IL2RG
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	0.00139358575150418	-6.57587517615468	42	23	0.00712294828120161	3229	10285	85236,7320,7321,7314,7311,8345,6233,255626,7323,7332,56254,7319,7334,220441,8915,51255,9810,8342,79577,8970,10670,80349,8348	H2BC12,UBE2B,UBE2D1,UBB,UBA52,H2BC9,RPS27A,H2BC1,UBE2D3,UBE2L3,RNF20,UBE2A,UBE2N,RNF152,BCL10,RNF181,RNF40,H2BC14,CDC73,H2BC11,RRAGA,SKIC8,H2BC17
R-HSA-186763	Downstream signal transduction	0.00139726375302213	-6.57323941694136	352	137	0.0424279962836792	3229	10285	5694,5683,108,1742,940,1445,8315,5685,122706,5705,2260,3558,5699,5684,5693,109,1027,5704,5709,1385,5695,3717,5295,1399,10768,5689,5567,5578,7314,6776,5518,10213,5781,4690,5713,941,8822,6711,26523,5536,5153,5720,284,53358,5906,6772,208,3716,2252,5718,5581,1026,8503,1437,11221,4747,2931,572,4296,5698,200734,3559,2248,5721,9861,1839,6709,5136,8394,5529,5037,5691,4233,152559,8074,5728,5686,4193,7529,1848,2246,5525,3561,5296,29851,27006,7311,84292,5894,57690,5908,5604,3845,4343,2255,118788,10817,5716,6714,1852,5690,5707,5290,8682,5687,207,10000,3815,28956,5516,3265,6778,2549,3567,79837,7450,8870,5700,8452,8823,3560,8649,818,6233,3562,5710,5245,161742,5702,7157,942,5682,7979,1843,25780,6464,5692	PSMB6,PSMA2,ADCY2,DLG4,CD28,CSK,BRAP,PSMA4,PSMB11,PSMC5,FGFR1,IL2,PSMB10,PSMA3,PSMB5,ADCY3,CDKN1B,PSMC4,PSMD3,CREB1,PSMB7,JAK2,PIK3R1,CRKL,AHCYL1,PSMB1,PRKACB,PRKCA,UBB,STAT5A,PPP2R1A,PSMD14,PTPN11,NCK1,PSMD7,CD80,FGF17,SPTBN1,AGO1,PPP5C,PDE1B,PSME1,ANGPT1,SHC3,RAP1A,STAT1,AKT2,JAK1,FGF7,PSMD12,PRKCE,CDKN1A,PIK3R3,CSF2,DUSP10,NEFL,GSK3A,BAD,MAP3K11,PSMB9,SPRED2,IL2RA,FGF3,PSME2,PSMD6,HBEGF,SPTAN1,PDE1A,PIP5K1A,PPP2R5E,PEBP1,PSMB3,MET,PAQR3,FGF23,PTEN,PSMA5,MDM2,YWHAB,DUSP6,FGF1,PPP2R5A,IL2RG,PIK3R2,ICOS,FGF22,UBA52,WDR83,RAF1,TNRC6C,RAP1B,MAP2K1,KRAS,MOV10,FGF10,PIK3AP1,FRS3,PSMD10,SRC,DUSP9,PSMB2,PSMD1,PIK3CA,PEA15,PSMA6,AKT1,AKT3,KIT,LAMTOR2,PPP2CB,HRAS,STAT6,GAB1,IL5,PIP4K2C,VWF,IER3,PSMC1,CUL3,FGF16,IL2RB,LAMTOR3,CAMK2G,RPS27A,IL3,PSMD4,PHB1,SPRED1,PSMC3,TP53,CD86,PSMA1,SEM1,DUSP1,RASGRP3,SHC1,PSMB4
R-HSA-909733	Interferon alpha/beta signaling	0.00141609404418881	-6.55985287052844	69	34	0.0105295757200372	3229	10285	4938,3430,25939,6041,3447,3669,4600,9021,3661,684,3446,3716,9636,3660,3664,3433,10379,3440,3665,3394,2537,6772,3659,3429,4599,3456,3454,6773,3662,5781,54739,5770,91543,1958	OAS1,IFI35,SAMHD1,RNASEL,IFNA13,ISG20,MX2,SOCS3,IRF3,BST2,IFNA10,JAK1,ISG15,IRF2,IRF6,IFIT2,IRF9,IFNA2,IRF7,IRF8,IFI6,STAT1,IRF1,IFI27,MX1,IFNB1,IFNAR1,STAT2,IRF4,PTPN11,XAF1,PTPN1,RSAD2,EGR1
R-HSA-187037	NGF signalling via TRKA from the plasma membrane	0.00148994441112457	-6.50901646769081	387	149	0.0461443171260452	3229	10285	28956,3815,5516,3265,2549,3567,79837,5707,5690,5290,8682,207,5687,10000,8823,3560,818,8649,7450,5898,8870,5700,8452,5702,7157,942,5682,6233,3562,5245,5710,161742,6464,25780,1845,5692,7979,1843,4233,152559,8074,5728,5686,6709,5136,160,5529,8394,5037,5691,3561,5296,2002,29851,4193,7529,1848,2246,5525,5899,5908,5604,3845,27006,7311,84292,5894,57690,6016,10817,5716,6714,1852,4343,118788,2255,1175,208,1173,53358,4205,5906,466,1026,5581,8503,1437,7867,3716,2252,5718,2931,4296,572,11221,10126,4747,2248,5721,9861,1839,5698,200734,3559,1785,5685,122706,3558,2260,5705,5699,4915,5694,5683,108,1742,940,1445,8315,5709,1385,5695,3717,5295,1399,10768,5689,5693,5684,109,1027,5704,10213,4208,5781,5578,5567,7314,5518,6014,6711,26523,5536,5153,5720,284,5713,941,8822	LAMTOR2,KIT,PPP2CB,HRAS,GAB1,IL5,PIP4K2C,PSMD1,PSMB2,PIK3CA,PEA15,AKT1,PSMA6,AKT3,FGF16,IL2RB,CAMK2G,LAMTOR3,VWF,RALA,IER3,PSMC1,CUL3,PSMC3,TP53,CD86,PSMA1,RPS27A,IL3,PHB1,PSMD4,SPRED1,SHC1,RASGRP3,DUSP3,PSMB4,SEM1,DUSP1,MET,PAQR3,FGF23,PTEN,PSMA5,SPTAN1,PDE1A,AP2A1,PPP2R5E,PIP5K1A,PEBP1,PSMB3,IL2RG,PIK3R2,ELK1,ICOS,MDM2,YWHAB,DUSP6,FGF1,PPP2R5A,RALB,RAP1B,MAP2K1,KRAS,FGF22,UBA52,WDR83,RAF1,TNRC6C,RIT1,FRS3,PSMD10,SRC,DUSP9,MOV10,PIK3AP1,FGF10,AP2S1,AKT2,AP2M1,SHC3,MEF2A,RAP1A,ATF1,CDKN1A,PRKCE,PIK3R3,CSF2,MAPKAPK3,JAK1,FGF7,PSMD12,GSK3A,MAP3K11,BAD,DUSP10,DNAL4,NEFL,FGF3,PSME2,PSMD6,HBEGF,PSMB9,SPRED2,IL2RA,DNM2,PSMA4,PSMB11,IL2,FGFR1,PSMC5,PSMB10,NTRK2,PSMB6,PSMA2,ADCY2,DLG4,CD28,CSK,BRAP,PSMD3,CREB1,PSMB7,JAK2,PIK3R1,CRKL,AHCYL1,PSMB1,PSMB5,PSMA3,ADCY3,CDKN1B,PSMC4,PSMD14,MEF2C,PTPN11,PRKCA,PRKACB,UBB,PPP2R1A,RIT2,SPTBN1,AGO1,PPP5C,PDE1B,PSME1,ANGPT1,PSMD7,CD80,FGF17
R-HSA-8853659	RET signaling	0.00150085609929918	-6.50171960081391	270	108	0.0334468875812945	3229	10285	5906,53358,5718,3716,2252,8503,1437,11221,4747,4296,5698,200734,3559,9861,1839,2248,5721,1742,1445,8315,5683,5694,122706,5705,3558,2260,5699,5685,5704,5693,5684,5295,5689,5709,3717,5695,7314,5518,5578,5567,5781,10213,5713,8822,5720,284,6711,5536,5290,5687,8682,5707,5690,5516,3815,28956,3265,2549,3567,5700,8452,7450,3560,55816,818,8649,8823,5245,5710,161742,6233,3562,5682,5702,1843,220164,7979,5692,6464,25780,5037,5691,6709,5529,8074,5686,4233,152559,1848,2887,2246,5525,7529,5296,3561,5894,27006,55715,7311,84292,5604,3845,5908,2255,6714,1852,10817,5716	RAP1A,SHC3,PSMD12,JAK1,FGF7,PIK3R3,CSF2,DUSP10,NEFL,MAP3K11,PSMB9,SPRED2,IL2RA,PSMD6,HBEGF,FGF3,PSME2,DLG4,CSK,BRAP,PSMA2,PSMB6,PSMB11,PSMC5,IL2,FGFR1,PSMB10,PSMA4,PSMC4,PSMB5,PSMA3,PIK3R1,PSMB1,PSMD3,JAK2,PSMB7,UBB,PPP2R1A,PRKCA,PRKACB,PTPN11,PSMD14,PSMD7,FGF17,PSME1,ANGPT1,SPTBN1,PPP5C,PIK3CA,PSMA6,PEA15,PSMD1,PSMB2,PPP2CB,KIT,LAMTOR2,HRAS,GAB1,IL5,PSMC1,CUL3,VWF,IL2RB,DOK5,CAMK2G,LAMTOR3,FGF16,PHB1,PSMD4,SPRED1,RPS27A,IL3,PSMA1,PSMC3,DUSP1,DOK6,SEM1,PSMB4,SHC1,RASGRP3,PEBP1,PSMB3,SPTAN1,PPP2R5E,FGF23,PSMA5,MET,PAQR3,DUSP6,GRB10,FGF1,PPP2R5A,YWHAB,PIK3R2,IL2RG,RAF1,FGF22,DOK4,UBA52,WDR83,MAP2K1,KRAS,RAP1B,FGF10,SRC,DUSP9,FRS3,PSMD10
R-HSA-1640170	Cell Cycle	0.00155392819369604	-6.46696923550708	621	229	0.0709197894084856	3229	10285	10762,5689,5861,991,81876,1460,8881,220134,7283,1019,5704,122706,10856,5685,4173,11258,8970,9184,9025,5683,4175,5694,5720,1022,983,85236,55135,644186,5925,10213,140609,5518,7314,5579,79023,5718,8607,119504,208,401541,55766,7532,2237,3014,1021,7514,25906,6119,4149,9972,5698,1457,8655,8331,10133,5862,7298,5984,91754,8345,54820,57804,3326,332,4751,1874,8342,11339,84296,595,5716,1454,4331,5885,54107,5500,7533,7443,57060,9656,4659,4000,54892,27030,80776,5700,64326,10403,3796,8317,55142,5516,3320,4085,79648,7341,207,203068,5707,5690,11097,8697,5810,23594,91687,896,10383,8335,4683,1736,619553,23636,5682,5710,4172,8350,5695,5709,56158,5001,1027,1032,80010,5684,5693,5699,2810,5705,147841,8348,387103,8815,6118,7112,5425,23291,6500,79980,23194,5713,10051,5578,246184,94239,1026,63943,3013,64785,23649,891,3015,4609,56655,1859,10776,7336,57122,4605,22919,5928,29882,9861,5985,7321,5721,79019,5983,51343,1031,255626,84057,348235,5111,890,7029,79003,129401,5931,8467,5982,1781,5525,80321,23592,7529,4193,5686,902,116028,5691,5529,5048,7534,1069,2033,6396,7015,51053,7311,11073,474382,29086,8636,84515,7334,7846,5687,10000,5692,55651,29945,9232,26003,83540,95681,672,7979,10121,7329,8334,5702,7157,51529,1163,4001,5932,5558,6233,5501	NUP50,PSMB1,RAB1A,CDC20,RAB1B,CSNK2B,CDC16,SKA1,TUBG1,CDK4,PSMC4,PSMB11,RUVBL2,PSMA4,MCM4,DCTN3,H2BC11,BUB3,RNF8,PSMA2,MCM6,PSMB6,PSME1,CDK7,CDK1,H2BC12,WRAP53,SYCE3,RB1,PSMD14,NEK7,PPP2R1A,UBB,PRKCB,NUP37,PSMD12,RUVBL1,ANAPC16,AKT2,CENPP,H2AJ,YWHAG,FEN1,H2AX,CDK6,XPO1,ANAPC15,RPA3,MAX,NUP153,PSMB9,CSNK2A1,DYNLL1,H2AC14,OPTN,RAB2A,TYMS,RFC4,NEK9,H2BC9,NDE1,POLD4,HSP90AB1,BIRC5,NEK2,E2F4,H2BC14,OIP5,GINS4,CCND1,PSMD10,CSNK1E,MNAT1,RAD21,POLE3,PPP1CB,YWHAH,VRK1,PCBP4,MDC1,PPP1R12A,LMNA,NCAPG2,MLH3,B9D2,PSMC1,COP1,NDC80,KIF2A,CDC7,HAUS2,PPP2CB,HSP90AA1,MAD2L1,MCPH1,SUMO1,AKT1,TUBB,PSMD1,PSMB2,NUP42,CDC23,RAD1,ORC6,CENPL,CCND3,TUBB4B,H2AC4,NBN,DKC1,MIR484,NUP62,PSMA1,PSMD4,MCM3,H3C1,PSMB7,PSMD3,TEX12,ORC5,CDKN1B,CDKN2D,RMI1,PSMA3,PSMB5,PSMB10,SFN,PSMC5,SPC24,H2BC17,CENPW,BANF1,RPA2,TMPO,POLD2,FBXW11,SKP1,DSN1,FBXL7,PSMD7,SMC4,PRKCA,CDC26,H2AZ2,CDKN1A,FKBPL,H2AC7,GINS3,POLA2,CCNB1,H2AZ1,MYC,POLE4,DYRK1A,ARPP19,UBE2V2,NUP107,MYBL2,MAPRE1,RBBP4,ANAPC2,PSMD6,RFC5,UBE2D1,PSME2,CENPM,RFC3,FZR1,CDKN2C,H2BC1,MND1,SKA2,PCNA,CCNA2,TFDP2,MIS12,NUP35,RBBP7,SMARCA5,RFC2,DYNC1I2,PPP2R5A,CEP70,LEMD3,YWHAB,MDM2,PSMA5,CCNH,RMI2,PSMB3,PPP2R5E,PAFAH1B1,YWHAZ,CETN2,EP300,SEC13,TERT,GMNN,UBA52,TOPBP1,H2AB1,BABAM1,SSNA1,MCM8,UBE2N,TUBA1A,PSMA6,AKT3,PSMB4,NHP2,ANAPC4,PTTG1,GORASP2,NUF2,CEP41,BRCA1,SEM1,ACTR1A,UBE2I,H2AC6,PSMC3,TP53,ANAPC11,CKS1B,LMNB1,RBBP8,PRIM2,RPS27A,PPP1CC
R-HSA-195721	Signaling by Wnt	0.00162923396027876	-6.41964533764986	336	131	0.0405698358624961	3229	10285	1175,3014,7476,7088,208,55766,50855,1173,1452,2785,7514,79577,6662,3013,94239,2793,2784,5579,8607,3015,4609,50964,5718,8331,1457,255626,59345,7976,8345,5530,5721,6422,9861,5698,80351,5880,5685,8348,5699,122706,5705,5694,5683,5330,50999,8658,8970,5695,5709,1460,8350,5689,6657,5684,5693,5704,7472,10213,59349,2788,5578,1487,5518,7314,9101,26523,8322,5720,6500,55970,54331,85236,5713,57154,5516,2791,2775,5690,5707,5687,207,1856,474382,8323,8452,8724,5700,1387,1499,5702,857,8334,5682,6233,81847,100126338,5710,9559,5692,11197,7979,8335,4040,2787,23236,5686,2790,5529,51764,160,8342,5691,22943,7480,56998,5145,5525,7015,607,23002,2782,7311,57690,55366,5716,23072,1454,4343,7534,2033,6658	AP2S1,H2AX,WNT7A,TLE1,AKT2,H2AJ,PARD6A,AP2M1,CSNK1A1,GNG3,XPO1,CDC73,SOX9,H2AC7,H2AZ2,GNGT2,GNB3,PRKCB,RUVBL1,H2AZ1,MYC,SOST,PSMD12,H2AC14,CSNK2A1,H2BC1,GNB4,FZD3,H2BC9,PPP3CA,PSME2,SFRP1,PSMD6,PSMB9,TNKS2,RAC2,PSMA4,H2BC17,PSMB10,PSMB11,PSMC5,PSMB6,PSMA2,PLCB2,TMED5,TNKS,H2BC11,PSMB7,PSMD3,CSNK2B,H3C1,PSMB1,SOX2,PSMA3,PSMB5,PSMC4,WNT2,PSMD14,KLHL12,GNG7,PRKCA,CTBP1,PPP2R1A,UBB,USP8,AGO1,FZD4,PSME1,SKP1,GNG12,GNG2,H2BC12,PSMD7,SMURF1,PPP2CB,GNG11,GNAO1,PSMB2,PSMD1,PSMA6,AKT1,DVL2,H2AB1,FZD6,CUL3,SNX3,PSMC1,CREBBP,CTNNB1,PSMC3,CAV1,H2AC6,PSMA1,RPS27A,RNF146,MIR937,PSMD4,VPS26A,PSMB4,WIF1,SEM1,H2AC4,LRP6,GNG5,PLCB1,PSMA5,GNG10,PPP2R5E,GNG13,AP2A1,H2BC14,PSMB3,DKK1,WNT10B,CTNNBIP1,PDE6A,PPP2R5A,TERT,BCL9,DAAM1,GNB1,UBA52,TNRC6C,LGR4,PSMD10,HECW1,CSNK1E,MOV10,YWHAZ,EP300,SOX3
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.00163456763782747	-6.41637695129953	24	15	0.00464540105295757	3229	10285	5423,5111,328,54107,2237,6118,10038,5984,5425,5985,57804,5982,6119,5983,56655	POLB,PCNA,APEX1,POLE3,FEN1,RPA2,PARP2,RFC4,POLD2,RFC5,POLD4,RFC2,RPA3,RFC3,POLE4
R-HSA-453274	Mitotic G2-G2/M phases	0.00163963001798126	-6.41328466138918	184	77	0.0238463920718489	3229	10285	9861,5692,5721,10383,5698,10121,619553,95681,7979,5682,8655,5702,7157,5710,890,10133,6233,63943,1026,8636,5718,891,5700,7846,5516,7532,55142,4605,3320,5687,7514,5690,5707,5928,22919,203068,6500,1022,983,5720,1454,5716,23194,1069,5713,2033,5048,4331,10213,5500,7314,5518,4659,7311,5689,54820,5709,3326,5695,7283,5704,1781,4751,5693,5684,80321,122706,5705,5699,902,5686,11258,5685,5691,23291,5683,5694	PSMD6,PSMB4,PSME2,TUBB4B,PSMB9,ACTR1A,MIR484,CEP41,SEM1,PSMA1,DYNLL1,PSMC3,TP53,PSMD4,CCNA2,OPTN,RPS27A,FKBPL,CDKN1A,SSNA1,PSMD12,CCNB1,PSMC1,TUBA1A,PPP2CB,YWHAG,HAUS2,MYBL2,HSP90AA1,PSMA6,XPO1,PSMB2,PSMD1,RBBP4,MAPRE1,TUBB,SKP1,CDK7,CDK1,PSME1,CSNK1E,PSMD10,FBXL7,CETN2,PSMD7,EP300,PAFAH1B1,MNAT1,PSMD14,PPP1CB,UBB,PPP2R1A,PPP1R12A,UBA52,PSMB1,NDE1,PSMD3,HSP90AB1,PSMB7,TUBG1,PSMC4,DYNC1I2,NEK2,PSMB5,PSMA3,CEP70,PSMB11,PSMC5,PSMB10,CCNH,PSMA5,DCTN3,PSMA4,PSMB3,FBXW11,PSMA2,PSMB6
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	0.00173728192461183	-6.35543349941727	271	108	0.0334468875812945	3229	10285	5290,8682,5687,5707,5690,5516,28956,3815,3265,3567,5700,8452,7450,3560,818,8649,8823,5245,5710,161742,6233,3562,5682,5702,1843,7979,5692,25780,6464,5037,5691,7525,6709,5529,8074,5686,4233,152559,1848,2246,5525,7529,3561,5296,5894,6850,27006,7311,84292,5604,3845,5908,7534,2255,6714,1852,10817,5716,5906,53358,5718,3716,2252,8503,1437,11221,4747,4296,5698,3559,200734,9861,1839,2248,5721,1742,1445,8315,5694,5683,122706,3558,2260,5705,5699,5685,5704,5693,5684,5295,1399,5689,5709,5695,3717,3636,7314,867,6776,5518,5781,10213,5713,8822,5720,284,6711,5536	PIK3CA,PEA15,PSMA6,PSMD1,PSMB2,PPP2CB,LAMTOR2,KIT,HRAS,IL5,PSMC1,CUL3,VWF,IL2RB,CAMK2G,LAMTOR3,FGF16,PHB1,PSMD4,SPRED1,RPS27A,IL3,PSMA1,PSMC3,DUSP1,SEM1,PSMB4,RASGRP3,SHC1,PEBP1,PSMB3,YES1,SPTAN1,PPP2R5E,FGF23,PSMA5,MET,PAQR3,DUSP6,FGF1,PPP2R5A,YWHAB,IL2RG,PIK3R2,RAF1,SYK,FGF22,UBA52,WDR83,MAP2K1,KRAS,RAP1B,YWHAZ,FGF10,SRC,DUSP9,FRS3,PSMD10,RAP1A,SHC3,PSMD12,JAK1,FGF7,PIK3R3,CSF2,DUSP10,NEFL,MAP3K11,PSMB9,IL2RA,SPRED2,PSMD6,HBEGF,FGF3,PSME2,DLG4,CSK,BRAP,PSMB6,PSMA2,PSMB11,IL2,FGFR1,PSMC5,PSMB10,PSMA4,PSMC4,PSMB5,PSMA3,PIK3R1,CRKL,PSMB1,PSMD3,PSMB7,JAK2,INPPL1,UBB,CBL,STAT5A,PPP2R1A,PTPN11,PSMD14,PSMD7,FGF17,PSME1,ANGPT1,SPTBN1,PPP5C
R-HSA-196836	Vitamin C (ascorbate) metabolism	0.00173761774245421	-6.35524021738003	8	7	0.00216785382471353	3229	10285	9446,6513,119391,1727,1528,6515,9962	GSTO1,SLC2A1,GSTO2,CYB5R3,CYB5A,SLC2A3,SLC23A2
R-HSA-5654736	Signaling by FGFR1	0.00190250465176357	-6.26458402315201	50	26	0.00805202849179312	3229	10285	8822,2255,23767,200734,6714,6464,2248,10817,7314,161742,867,5518,27006,7311,6233,3845,5781,2246,5295,23768,5290,8074,2260,5516,3265,2549	FGF17,FGF10,FLRT3,SPRED2,SRC,SHC1,FGF3,FRS3,UBB,SPRED1,CBL,PPP2R1A,FGF22,UBA52,RPS27A,KRAS,PTPN11,FGF1,PIK3R1,FLRT2,PIK3CA,FGF23,FGFR1,PPP2CB,HRAS,GAB1
R-HSA-5610787	Hedgehog 'off' state	0.00190342767758036	-6.26409897730516	101	46	0.0142458965624032	3229	10285	7314,5567,7311,10213,5713,5720,6500,5716,5691,55081,108,5694,5683,5699,5686,122706,5705,5685,7289,5704,109,5693,5684,5689,5695,5709,5710,6233,5682,5702,7979,5698,5692,9861,5721,1452,5687,57728,5707,5690,51098,51684,5700,5718,23322,26160	UBB,PRKACB,UBA52,PSMD14,PSMD7,PSME1,SKP1,PSMD10,PSMB3,IFT57,ADCY2,PSMB6,PSMA2,PSMB10,PSMA5,PSMB11,PSMC5,PSMA4,TULP3,PSMC4,ADCY3,PSMB5,PSMA3,PSMB1,PSMB7,PSMD3,PSMD4,RPS27A,PSMA1,PSMC3,SEM1,PSMB9,PSMB4,PSMD6,PSME2,CSNK1A1,PSMA6,WDR19,PSMD1,PSMB2,IFT52,SUFU,PSMC1,PSMD12,RPGRIP1L,IFT172
R-HSA-199977	ER to Golgi Anterograde Transport	0.00191670235462562	-6.25714909320966	133	58	0.0179622174047693	3229	10285	8774,11258,100313843,51128,6709,372,23256,51164,1075,27095,375,81876,5861,11070,8775,2890,11014,55014,1781,51014,6396,51693,10282,5265,11316,9382,51399,6811,6711,4253,10175,9527,10652,23423,966,51226,54732,7109,26286,58485,9117,55738,1780,2348,378,79090,8655,3998,122553,10484,10671,51272,26984,10945,9570,10113,9554,10342	NAPG,DCTN3,MIR711,SAR1B,SPTAN1,ARCN1,SCFD1,DCTN4,CTSC,TRAPPC3,ARF1,RAB1B,RAB1A,TMEM115,NAPA,GRIA1,KDELR2,STX17,DYNC1I2,TMED7,SEC13,TRAPPC2L,BET1,SERPINA1,COPE,COG1,TRAPPC4,STX5,SPTBN1,MIA2,CNIH1,GOSR1,YKT6,TMED3,CD59,COPZ2,TMED9,TRAPPC10,ARFGAP3,TRAPPC1,SEC22C,ARFGAP1,DYNC1I1,FOLR1,ARF4,TRAPPC6A,DYNLL1,LMAN1,TRAPPC6B,SEC23A,DCTN6,BET1L,SEC22A,KDELR1,GOSR2,PREB,SEC22B,TFG
R-HSA-162587	HIV Life Cycle	0.00193180176928781	-6.24930215234425	152	65	0.0201300712294828	3229	10285	25978,22916,6829,92421,9525,23636,9972,2960,27243,404672,129401,6233,6880,6749,2071,6882,2959,1234,5045,7520,920,5901,51160,1025,79023,57122,7514,5438,11097,2962,2968,27183,7251,5432,51534,3159,2237,5431,5478,6873,4331,1022,3836,2961,5902,7314,6917,5441,7311,5433,2966,2963,2958,6827,6921,5436,6881,6879,5435,7852,10762,51510,902,8815,2957	CHMP2B,NCBP2,SUPT5H,CHMP4C,VPS4B,NUP62,NUP153,GTF2E1,CHMP2A,GTF2H5,NUP35,RPS27A,TAF9,SSRP1,ERCC3,TAF11,GTF2B,CCR5,FURIN,XRCC5,CD4,RAN,VPS28,CDK9,NUP37,NUP107,XPO1,POLR2I,NUP42,GTF2F1,GTF2H4,VPS4A,TSG101,POLR2C,VTA1,HMGA1,FEN1,POLR2B,PPIA,TAF2,MNAT1,CDK7,KPNA1,GTF2E2,RANBP1,UBB,TCEA1,POLR2L,UBA52,POLR2D,GTF2H2,GTF2F2,GTF2A2,SUPT4H1,ELOC,POLR2G,TAF10,TAF7,POLR2F,CXCR4,NUP50,CHMP5,CCNH,BANF1,GTF2A1
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.00196918264616875	-6.23013672274919	65	32	0.00991018891297615	3229	10285	57804,5982,2071,56655,5432,3980,902,2968,27339,6118,5425,5438,5985,1022,6119,5983,5431,2033,4331,5436,5435,54107,5111,5984,6917,7314,6233,2966,5441,404672,7311,5433	POLD4,RFC2,ERCC3,POLE4,POLR2C,LIG3,CCNH,GTF2H4,PRPF19,RPA2,POLD2,POLR2I,RFC5,CDK7,RPA3,RFC3,POLR2B,EP300,MNAT1,POLR2G,POLR2F,POLE3,PCNA,RFC4,TCEA1,UBB,RPS27A,GTF2H2,POLR2L,GTF2H5,UBA52,POLR2D
R-HSA-5655253	Signaling by FGFR2 in disease	0.00211487407414472	-6.15876000766792	43	23	0.00712294828120161	3229	10285	5295,8823,2246,2252,5432,8074,2549,3265,5290,2962,5438,2248,2255,8822,5431,22916,5436,3845,2963,5435,5433,5441,27006	PIK3R1,FGF16,FGF1,FGF7,POLR2C,FGF23,GAB1,HRAS,PIK3CA,GTF2F1,POLR2I,FGF3,FGF10,FGF17,POLR2B,NCBP2,POLR2G,KRAS,GTF2F2,POLR2F,POLR2D,POLR2L,FGF22
R-HSA-2428928	IRS-related events triggered by IGF1R	0.00212454783413576	-6.15419628318358	298	117	0.0362341282130691	3229	10285	152559,55437,4233,5686,8074,1977,54106,5529,6709,5691,5037,5296,3561,7529,5525,2246,1848,5908,3845,5604,84292,7311,27006,5894,5716,10817,1852,6714,2255,3567,3265,2549,5516,3815,28956,5690,5707,8682,207,5687,5290,8823,8649,818,3560,7450,5700,5571,8452,5702,5682,3562,6233,161742,5245,5710,25780,6464,5692,7979,1843,5564,5685,5699,2260,3558,5705,122706,5683,5694,8315,1445,6009,1742,5695,3717,5709,5689,5295,5684,5693,5704,10213,5781,6794,3479,5518,7314,5536,6711,284,5720,8822,5713,1975,208,53358,10670,5906,51719,1437,2252,55004,3716,5718,4296,10325,4747,11221,3480,5721,2248,1839,9861,3559,200734,5698	PAQR3,STRADB,MET,PSMA5,FGF23,EIF4E,TLR9,PPP2R5E,SPTAN1,PSMB3,PEBP1,PIK3R2,IL2RG,YWHAB,PPP2R5A,FGF1,DUSP6,RAP1B,KRAS,MAP2K1,WDR83,UBA52,FGF22,RAF1,PSMD10,FRS3,DUSP9,SRC,FGF10,IL5,HRAS,GAB1,PPP2CB,KIT,LAMTOR2,PSMB2,PSMD1,PEA15,AKT1,PSMA6,PIK3CA,FGF16,LAMTOR3,CAMK2G,IL2RB,VWF,PSMC1,PRKAG1,CUL3,PSMC3,PSMA1,IL3,RPS27A,SPRED1,PHB1,PSMD4,RASGRP3,SHC1,PSMB4,SEM1,DUSP1,PRKAB1,PSMA4,PSMB10,FGFR1,IL2,PSMC5,PSMB11,PSMA2,PSMB6,BRAP,CSK,RHEB,DLG4,PSMB7,JAK2,PSMD3,PSMB1,PIK3R1,PSMA3,PSMB5,PSMC4,PSMD14,PTPN11,STK11,IGF1,PPP2R1A,UBB,PPP5C,SPTBN1,ANGPT1,PSME1,FGF17,PSMD7,EIF4B,AKT2,SHC3,RRAGA,RAP1A,CAB39,CSF2,FGF7,LAMTOR1,JAK1,PSMD12,MAP3K11,RRAGB,NEFL,DUSP10,IGF1R,PSME2,FGF3,HBEGF,PSMD6,IL2RA,SPRED2,PSMB9
R-HSA-2428924	IGF1R signaling cascade	0.00212454783413576	-6.15419628318358	298	117	0.0362341282130691	3229	10285	5682,5702,161742,5710,5245,3562,6233,5692,25780,6464,1843,5564,7979,3567,2549,3265,28956,3815,5516,8682,207,5687,5290,5707,5690,818,8649,3560,8823,5700,8452,5571,7450,3845,5604,5908,5894,84292,7311,27006,1852,6714,5716,10817,2255,5686,8074,152559,4233,55437,5691,5037,54106,1977,5529,6709,5296,3561,5525,2246,1848,7529,4296,4747,11221,3480,10325,1839,9861,5721,2248,3559,200734,5698,1975,208,5906,10670,53358,1437,51719,5718,2252,3716,55004,5781,10213,5518,7314,6794,3479,284,5720,5536,6711,8822,5713,5699,2260,3558,5705,122706,5685,8315,1445,6009,1742,5694,5683,5689,5295,3717,5695,5709,5704,5684,5693	PSMA1,PSMC3,SPRED1,PSMD4,PHB1,IL3,RPS27A,PSMB4,RASGRP3,SHC1,DUSP1,PRKAB1,SEM1,IL5,GAB1,HRAS,LAMTOR2,KIT,PPP2CB,PEA15,AKT1,PSMA6,PIK3CA,PSMD1,PSMB2,CAMK2G,LAMTOR3,IL2RB,FGF16,PSMC1,CUL3,PRKAG1,VWF,KRAS,MAP2K1,RAP1B,RAF1,WDR83,UBA52,FGF22,DUSP9,SRC,PSMD10,FRS3,FGF10,PSMA5,FGF23,PAQR3,MET,STRADB,PSMB3,PEBP1,TLR9,EIF4E,PPP2R5E,SPTAN1,PIK3R2,IL2RG,PPP2R5A,FGF1,DUSP6,YWHAB,MAP3K11,NEFL,DUSP10,IGF1R,RRAGB,HBEGF,PSMD6,PSME2,FGF3,IL2RA,SPRED2,PSMB9,EIF4B,AKT2,RAP1A,RRAGA,SHC3,CSF2,CAB39,PSMD12,FGF7,JAK1,LAMTOR1,PTPN11,PSMD14,PPP2R1A,UBB,STK11,IGF1,ANGPT1,PSME1,PPP5C,SPTBN1,FGF17,PSMD7,PSMB10,FGFR1,IL2,PSMC5,PSMB11,PSMA4,BRAP,CSK,RHEB,DLG4,PSMB6,PSMA2,PSMB1,PIK3R1,JAK2,PSMB7,PSMD3,PSMC4,PSMA3,PSMB5
R-HSA-2586552	Signaling by Leptin	0.00225592907280076	-6.09419338520192	253	101	0.031279033756581	3229	10285	8315,1445,1742,5683,5694,5699,3558,2260,5705,122706,5685,5704,5684,5693,5689,3717,5695,5709,5518,6776,7314,5781,10213,8822,5713,284,5720,3952,5536,6711,5906,53358,5718,2252,3716,1437,4747,11221,4296,3559,200734,5698,1839,9861,5721,2248,5691,5037,5529,6709,5686,8074,152559,4233,5525,2246,1848,7529,9021,3561,5894,84292,7311,27006,3845,5604,5908,2255,1852,6714,5716,10817,5687,8682,5690,5707,3567,3265,3815,28956,5516,8452,5700,3953,7450,818,8649,3560,8823,161742,5710,5245,3562,6233,5682,5702,1843,7979,5692,6464,25780	BRAP,CSK,DLG4,PSMA2,PSMB6,PSMB10,IL2,FGFR1,PSMC5,PSMB11,PSMA4,PSMC4,PSMA3,PSMB5,PSMB1,JAK2,PSMB7,PSMD3,PPP2R1A,STAT5A,UBB,PTPN11,PSMD14,FGF17,PSMD7,ANGPT1,PSME1,LEP,PPP5C,SPTBN1,RAP1A,SHC3,PSMD12,FGF7,JAK1,CSF2,NEFL,DUSP10,MAP3K11,IL2RA,SPRED2,PSMB9,HBEGF,PSMD6,PSME2,FGF3,PSMB3,PEBP1,PPP2R5E,SPTAN1,PSMA5,FGF23,PAQR3,MET,PPP2R5A,FGF1,DUSP6,YWHAB,SOCS3,IL2RG,RAF1,WDR83,UBA52,FGF22,KRAS,MAP2K1,RAP1B,FGF10,DUSP9,SRC,PSMD10,FRS3,PSMA6,PEA15,PSMB2,PSMD1,IL5,HRAS,KIT,LAMTOR2,PPP2CB,CUL3,PSMC1,LEPR,VWF,CAMK2G,LAMTOR3,IL2RB,FGF16,SPRED1,PSMD4,PHB1,IL3,RPS27A,PSMA1,PSMC3,DUSP1,SEM1,PSMB4,SHC1,RASGRP3
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.00227904106151128	-6.08400051154379	68	33	0.0102198823165067	3229	10285	55703,3146,3551,2033,4615,29110,4792,51082,5435,1499,7314,171568,5441,7311,6233,7520,22954,7098,6737,84265,4793,115004,6285,1387,3661,10621,177,3665,4790,6778,148022,1660,3428	POLR3B,HMGB1,IKBKB,EP300,MYD88,TBK1,NFKBIA,POLR1D,POLR2F,CTNNB1,UBB,POLR3H,POLR2L,UBA52,RPS27A,XRCC5,TRIM32,TLR3,TRIM21,POLR3GL,NFKBIB,CGAS,S100B,CREBBP,IRF3,POLR3F,AGER,IRF7,NFKB1,STAT6,TICAM1,DHX9,IFI16
R-HSA-163210	Formation of ATP by chemiosmotic coupling	0.00234864559430543	-6.05391645982421	16	11	0.00340662743883555	3229	10285	522,506,10632,518,498,539,514,515,513,516,10476	ATP5PF,ATP5F1B,ATP5MG,ATP5MC3,ATP5F1A,ATP5PO,ATP5F1E,ATP5PB,ATP5F1D,ATP5MC1,ATP5PD
R-HSA-110312	Translesion synthesis by REV1	0.00234864559430543	-6.05391645982421	16	11	0.00340662743883555	3229	10285	6119,5111,5982,5985,10459,6233,7311,5983,5984,7314,6118	RPA3,PCNA,RFC2,RFC5,MAD2L2,RPS27A,UBA52,RFC3,RFC4,UBB,RPA2
R-HSA-418594	G alpha (i) signalling events	0.00235540228817988	-6.05104374309602	242	97	0.030040260142459	3229	10285	3355,259285,108,84539,6364,4986,259292,256933,7852,2919,109,1230,187,283869,6363,10287,3576,2788,1232,2833,10563,54331,117579,55970,2785,27198,2921,4987,1236,8862,9170,4889,10663,9628,50833,259286,2771,2784,2793,1132,8698,64805,3577,54429,59345,2918,6370,2840,2847,6368,134,57007,3627,56477,51764,1814,2790,6001,2787,50837,6352,4887,6366,5030,1902,10850,2550,2782,50838,5539,8490,6750,6373,2831,2773,50865,1233,2791,1235,729230,1234,140,3350,2781,4886,4988,5368,2912,11255,5996,4283,4852,6387,1268,406974,5173,3361	HTR1F,TAS2R39,ADCY2,MCHR2,CCL20,OPRK1,TAS2R46,NPB,CXCR4,CXCL1,ADCY3,CCR1,APLNR,NPW,CCL19,RGS19,CXCL8,GNG7,CCR3,CXCR3,CXCL13,GNG2,RLN3,GNG12,GNG3,HCAR1,CXCL3,OPRL1,CCR7,APLN,LPAR2,NPY5R,CXCR6,RGS6,TAS2R16,TAS2R40,GNAI2,GNB3,GNGT2,CHRM4,S1PR4,P2RY12,CXCR1,TAS2R5,GNB4,GRM8,CCL25,GPR17,MCHR1,CCL23,ADORA1,ACKR3,CXCL10,CCL28,GNG13,DRD3,GNG10,RGS10,GNG5,TAS2R7,CCL5,NPY2R,CCL21,P2RY4,LPAR1,CCL27,GABBR1,GNB1,TAS2R13,PPY,RGS5,SST,CXCL11,NPBWR1,GNAI3,HEBP1,CCR4,GNG11,CCR6,CCR2,CCR5,ADORA3,HTR1A,GNAZ,NPY1R,OPRM1,PNOC,GRM2,HRH3,RGS1,CXCL9,NPY,CXCL12,CNR1,MIR197,PDYN,HTR5A
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	0.00240567289522901	-6.02992562444235	12	9	0.00278724063177454	3229	10285	54106,51284,7334,4615,51135,3665,7189,51311,7335	TLR9,TLR7,UBE2N,MYD88,IRAK4,IRF7,TRAF6,TLR8,UBE2V1
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.00242964160469422	-6.02001152028723	299	117	0.0362341282130691	3229	10285	2255,1852,6714,5716,10817,5894,84292,7311,27006,3845,5604,5908,5525,2246,1848,7529,5296,3561,5691,5037,54106,1977,5529,6709,5686,8074,152559,55437,4233,1843,5564,7979,5692,6464,25780,161742,5710,5245,3562,6233,5682,5702,5571,5700,8452,7450,818,8649,3560,8823,5687,8682,207,5290,5690,5707,3567,2549,3265,5516,3815,28956,8822,5713,284,5720,5536,6711,5518,7314,6794,3479,5781,10213,5704,5684,5693,5689,5295,5695,3717,5709,8315,1445,6009,1742,5694,5683,5699,5705,3558,2260,122706,5685,3559,200734,5698,1839,9861,5721,2248,4747,11221,3480,10325,4296,5718,2252,3716,55004,1437,51719,5906,10670,53358,1975,208	FGF10,DUSP9,SRC,PSMD10,FRS3,RAF1,WDR83,UBA52,FGF22,KRAS,MAP2K1,RAP1B,PPP2R5A,FGF1,DUSP6,YWHAB,PIK3R2,IL2RG,PSMB3,PEBP1,TLR9,EIF4E,PPP2R5E,SPTAN1,PSMA5,FGF23,PAQR3,STRADB,MET,DUSP1,PRKAB1,SEM1,PSMB4,SHC1,RASGRP3,SPRED1,PSMD4,PHB1,IL3,RPS27A,PSMA1,PSMC3,PRKAG1,PSMC1,CUL3,VWF,CAMK2G,LAMTOR3,IL2RB,FGF16,PSMA6,PEA15,AKT1,PIK3CA,PSMB2,PSMD1,IL5,GAB1,HRAS,PPP2CB,KIT,LAMTOR2,FGF17,PSMD7,ANGPT1,PSME1,PPP5C,SPTBN1,PPP2R1A,UBB,STK11,IGF1,PTPN11,PSMD14,PSMC4,PSMA3,PSMB5,PSMB1,PIK3R1,PSMB7,JAK2,PSMD3,BRAP,CSK,RHEB,DLG4,PSMB6,PSMA2,PSMB10,PSMC5,IL2,FGFR1,PSMB11,PSMA4,IL2RA,SPRED2,PSMB9,HBEGF,PSMD6,PSME2,FGF3,NEFL,DUSP10,IGF1R,RRAGB,MAP3K11,PSMD12,FGF7,JAK1,LAMTOR1,CSF2,CAB39,RAP1A,RRAGA,SHC3,EIF4B,AKT2
R-HSA-877312	Regulation of IFNG signaling	0.00243268728997504	-6.01875875201707	14	10	0.00309693403530505	3229	10285	9021,5781,8554,3717,3458,6772,3459,7341,3716,5770	SOCS3,PTPN11,PIAS1,JAK2,IFNG,STAT1,IFNGR1,SUMO1,JAK1,PTPN1
R-HSA-5653656	Vesicle-mediated transport	0.00253977022038353	-5.97568166645978	650	237	0.0733973366367296	3229	10285	64708,11258,55014,8775,154,81876,917,5861,8773,7314,6811,5265,9367,5873,51693,11336,10905,84251,3043,6711,9892,414918,26286,208,7163,51226,60560,7532,54732,1278,1080,811,27314,2512,51160,58485,8976,10133,29988,8655,9146,92421,10342,4620,26984,22836,125058,213,51272,3797,51510,6709,372,10097,9267,10640,112574,382,79735,7533,10228,11316,8673,10052,51014,149371,8675,122830,51552,57465,3039,27128,2495,27348,157807,4253,10175,948,9712,50813,9266,6844,207,3320,7018,5872,3796,6836,7251,5049,966,9230,5898,2348,5571,388552,1780,55738,1856,10981,122553,116442,10109,55850,79961,8905,79090,9554,9525,10945,374403,9570,10113,83452,2705,1075,2810,100313843,6869,1785,8774,11014,23216,11337,9318,8907,9382,867,4952,51399,23299,2589,2697,3312,10282,10749,9882,1281,23423,8766,10652,8322,53407,9527,55707,25977,1173,3512,127833,90196,5867,5878,29127,1175,4738,9827,115548,10987,920,7164,9117,8677,27243,11031,81631,51138,54662,4619,4943,8906,64837,3949,25978,6643,60561,7184,2706,10671,51164,160,2017,23256,11021,51128,9950,7037,4646,1781,7529,2890,51560,11070,27095,5864,375,7311,55763,5050,6396,55770,8301,7534,9341,5048,84694,23557,51542,6714,10000,7109,51209,27183,9342,51534,9371,134829,27131,57186,3240,378,11345,2665,10094,6845,9363,6233,3998,5868,51762,29763,5564,22931,5870,2590,10484,79571,80006	COPS7B,DCTN3,STX17,NAPA,ADRB2,RAB1B,CD3G,RAB1A,SNAP23,UBB,STX5,SERPINA1,RAB9A,RAB27A,TRAPPC2L,EXOC3,MAN1A2,SGIP1,HBB,SPTBN1,SNAP91,DENND6B,ARFGAP3,AKT2,TPD52,COPZ2,NAA35,YWHAG,TMED9,COL1A2,CFTR,CALR,RAB30,FTL,VPS28,TRAPPC1,WASL,OPTN,SLC2A8,DYNLL1,HGS,CHMP4C,TFG,MYH2,SEC22A,RHOBTB3,TBC1D16,ALB,BET1L,KIF3C,CHMP5,SPTAN1,ARCN1,ACTR2,CYTH1,EXOC5,SNX18,ARF6,TBC1D17,YWHAH,STX6,COPE,VAMP8,GJC1,TMED7,EXOC8,STX16,NAA30,RAB14,TBC1D24,HBA1,CYTH4,FTH1,TOR1B,CLVS1,MIA2,CNIH1,CD36,USP6NL,COPS7A,CYTH2,VAMP2,AKT1,HSP90AA1,TF,RAB13,KIF2A,SURF4,TSG101,PAFAH1B2,CD59,RAB11B,RALA,FOLR1,PRKAG1,BLOC1S3,DYNC1I1,ARFGAP1,DVL2,RAB32,TRAPPC6B,RAB39B,ARPC2,USE1,DENND2D,AP1S2,TRAPPC6A,SEC22B,VPS4B,KDELR1,TBC1D10C,GOSR2,PREB,RAB33B,GJB1,CTSC,SFN,MIR711,TACR1,DNM2,NAPG,KDELR2,TBC1D1,GABARAP,COPS2,AP1M1,COG1,CBL,OCRL,TRAPPC4,BICD2,GALNT1,GJA1,HSPA8,BET1,KIF1C,TBC1D4,COL3A1,TMED3,RAB11A,YKT6,FZD4,STX18,GOSR1,NECAP2,NECAP1,AP2M1,JCHAIN,SYT2,SYS1,RAB4A,RAB5C,RACGAP1,AP2S1,NEDD8,RGP1,FCHO2,COPS5,CD4,TPD52L1,SEC22C,STX10,CHMP2A,RAB31,MAP1LC3B,COPS4,TBC1D13,MYH1,TBC1D25,AP1G2,KLC2,LDLR,CHMP2B,SNX2,RINT1,HSP90B1,GJB2,DCTN6,DCTN4,AP2A1,CTTN,SCFD1,RAB35,SAR1B,GOLGA5,TFRC,MYO6,DYNC1I2,YWHAB,GRIA1,RAB6B,TMEM115,TRAPPC3,RAB3A,ARF1,UBA52,EXOC1,PAFAH1B3,SEC13,EXOC2,PICALM,YWHAZ,VAMP3,PAFAH1B1,GJA10,SNAPIN,VPS54,SRC,AKT3,TRAPPC10,RAB9B,VPS4A,SNAP29,VTA1,KIF3B,CLVS2,SNX5,RALGAPA2,HP,ARF4,GABARAPL2,GDI2,ARPC3,VAMP7,RAB33A,RPS27A,LMAN1,RAB5A,RAB8B,PACSIN3,PRKAB1,RAB18,RAB6A,GALNT2,SEC23A,GCC1,TRAPPC13
R-HSA-5684996	MAPK1/MAPK3 signaling	0.0025455354669206	-5.97341425153466	251	100	0.0309693403530505	3229	10285	4747,11221,4296,3559,200734,5698,1839,9861,5721,2248,5906,3572,53358,5718,2252,3716,1437,5518,7314,5781,10213,8822,5713,284,5720,983,5536,6711,8315,1445,1742,5683,5694,5699,3558,5705,2260,122706,5685,5704,3569,5693,5684,5689,5695,3717,5709,161742,5245,5710,3562,6233,5682,5702,1843,7979,5692,6464,25780,5687,8682,5707,5690,3567,3265,3815,28956,5516,8452,5700,7450,8649,818,3560,8823,5894,84292,7311,27006,3845,5604,5908,2255,1852,6714,5716,10817,5691,5037,5529,6709,5686,8074,152559,4233,5525,2246,1848,7529,3561	NEFL,DUSP10,MAP3K11,IL2RA,SPRED2,PSMB9,HBEGF,PSMD6,PSME2,FGF3,RAP1A,IL6ST,SHC3,PSMD12,FGF7,JAK1,CSF2,PPP2R1A,UBB,PTPN11,PSMD14,FGF17,PSMD7,ANGPT1,PSME1,CDK1,PPP5C,SPTBN1,BRAP,CSK,DLG4,PSMA2,PSMB6,PSMB10,IL2,PSMC5,FGFR1,PSMB11,PSMA4,PSMC4,IL6,PSMB5,PSMA3,PSMB1,PSMB7,JAK2,PSMD3,SPRED1,PHB1,PSMD4,IL3,RPS27A,PSMA1,PSMC3,DUSP1,SEM1,PSMB4,SHC1,RASGRP3,PSMA6,PEA15,PSMD1,PSMB2,IL5,HRAS,KIT,LAMTOR2,PPP2CB,CUL3,PSMC1,VWF,LAMTOR3,CAMK2G,IL2RB,FGF16,RAF1,WDR83,UBA52,FGF22,KRAS,MAP2K1,RAP1B,FGF10,DUSP9,SRC,PSMD10,FRS3,PSMB3,PEBP1,PPP2R5E,SPTAN1,PSMA5,FGF23,PAQR3,MET,PPP2R5A,FGF1,DUSP6,YWHAB,IL2RG
R-HSA-112399	IRS-mediated signalling	0.0026716409726661	-5.92506239885291	294	115	0.0356147414060081	3229	10285	6711,5536,5720,284,5713,8822,10213,5781,6794,7314,5518,5709,5695,3717,5295,5689,5693,5684,5704,5685,122706,2260,3558,5705,5699,5694,5683,1742,6009,1445,8315,2248,5721,9861,1839,5698,3559,200734,4296,10325,11221,4747,51719,1437,55004,3716,2252,5718,208,1975,10670,53358,5906,10817,5716,6714,1852,2255,5908,5604,3845,27006,7311,84292,5894,3561,5296,7529,1848,2246,5525,55437,4233,152559,8074,5686,6709,5529,54106,1977,5037,5691,6464,25780,5692,7979,5564,1843,5702,5682,6233,3562,5245,5710,161742,8823,3560,8649,818,7450,5700,8452,5571,3815,28956,5516,3265,2549,3567,5707,5690,5290,207,5687,8682	SPTBN1,PPP5C,PSME1,ANGPT1,PSMD7,FGF17,PSMD14,PTPN11,STK11,UBB,PPP2R1A,PSMD3,PSMB7,JAK2,PIK3R1,PSMB1,PSMB5,PSMA3,PSMC4,PSMA4,PSMB11,FGFR1,IL2,PSMC5,PSMB10,PSMB6,PSMA2,DLG4,RHEB,CSK,BRAP,FGF3,PSME2,PSMD6,HBEGF,PSMB9,IL2RA,SPRED2,MAP3K11,RRAGB,DUSP10,NEFL,CAB39,CSF2,LAMTOR1,JAK1,FGF7,PSMD12,AKT2,EIF4B,RRAGA,SHC3,RAP1A,FRS3,PSMD10,SRC,DUSP9,FGF10,RAP1B,MAP2K1,KRAS,FGF22,UBA52,WDR83,RAF1,IL2RG,PIK3R2,YWHAB,DUSP6,FGF1,PPP2R5A,STRADB,MET,PAQR3,FGF23,PSMA5,SPTAN1,PPP2R5E,TLR9,EIF4E,PEBP1,PSMB3,SHC1,RASGRP3,PSMB4,SEM1,PRKAB1,DUSP1,PSMC3,PSMA1,RPS27A,IL3,PHB1,PSMD4,SPRED1,FGF16,IL2RB,LAMTOR3,CAMK2G,VWF,PSMC1,CUL3,PRKAG1,KIT,LAMTOR2,PPP2CB,HRAS,GAB1,IL5,PSMD1,PSMB2,PIK3CA,AKT1,PSMA6,PEA15
R-HSA-74751	Insulin receptor signalling cascade	0.00272233198073546	-5.90626642012664	297	116	0.0359244348095386	3229	10285	5721,2248,1839,9861,3559,200734,5698,4296,10325,4747,11221,51719,1437,2252,55004,3716,5718,1975,208,10670,53358,5906,5536,6711,284,5720,8822,5713,10213,5781,6794,5518,7314,5695,3717,5709,5689,5295,5684,5693,5704,5685,5699,3558,5705,2260,122706,5683,5694,8315,1445,6009,1742,6464,25780,5692,7979,1843,5564,5702,5682,3562,6233,161742,5710,5245,8823,818,8649,3560,7450,5700,8452,5571,3567,3265,2549,3815,5516,28956,5690,5707,8682,5687,207,5290,5716,10817,1852,6714,2255,5908,3845,5604,84292,7311,27006,5894,3561,5296,7529,5525,2246,2887,1848,152559,4233,55437,5686,8074,1977,54106,5529,6709,5691,5037	PSME2,FGF3,HBEGF,PSMD6,IL2RA,SPRED2,PSMB9,MAP3K11,RRAGB,NEFL,DUSP10,CAB39,CSF2,FGF7,LAMTOR1,JAK1,PSMD12,EIF4B,AKT2,RRAGA,SHC3,RAP1A,PPP5C,SPTBN1,ANGPT1,PSME1,FGF17,PSMD7,PSMD14,PTPN11,STK11,PPP2R1A,UBB,PSMB7,JAK2,PSMD3,PSMB1,PIK3R1,PSMA3,PSMB5,PSMC4,PSMA4,PSMB10,IL2,PSMC5,FGFR1,PSMB11,PSMA2,PSMB6,BRAP,CSK,RHEB,DLG4,SHC1,RASGRP3,PSMB4,SEM1,DUSP1,PRKAB1,PSMC3,PSMA1,IL3,RPS27A,SPRED1,PSMD4,PHB1,FGF16,CAMK2G,LAMTOR3,IL2RB,VWF,PSMC1,CUL3,PRKAG1,IL5,HRAS,GAB1,KIT,PPP2CB,LAMTOR2,PSMB2,PSMD1,PEA15,PSMA6,AKT1,PIK3CA,PSMD10,FRS3,DUSP9,SRC,FGF10,RAP1B,KRAS,MAP2K1,WDR83,UBA52,FGF22,RAF1,IL2RG,PIK3R2,YWHAB,PPP2R5A,FGF1,GRB10,DUSP6,PAQR3,MET,STRADB,PSMA5,FGF23,EIF4E,TLR9,PPP2R5E,SPTAN1,PSMB3,PEBP1
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.0028139608279481	-5.87316224080328	79	37	0.0114586559306287	3229	10285	5436,54107,5435,5111,6917,5984,7314,9318,6233,2966,5433,7311,51138,404672,5441,5985,1022,6119,5983,5431,2033,4331,3980,5432,902,2968,27339,50813,6118,5425,64708,5438,10987,57804,5982,2071,56655	POLR2G,POLE3,POLR2F,PCNA,TCEA1,RFC4,UBB,COPS2,RPS27A,GTF2H2,POLR2D,UBA52,COPS4,GTF2H5,POLR2L,RFC5,CDK7,RPA3,RFC3,POLR2B,EP300,MNAT1,LIG3,POLR2C,CCNH,GTF2H4,PRPF19,COPS7A,RPA2,POLD2,COPS7B,POLR2I,COPS5,POLD4,RFC2,ERCC3,POLE4
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.00290747466444204	-5.84047038747286	25	15	0.00464540105295757	3229	10285	6119,5982,57804,5985,56655,5983,54107,5111,3980,6233,5425,7311,5984,6118,7314	RPA3,RFC2,POLD4,RFC5,POLE4,RFC3,POLE3,PCNA,LIG3,RPS27A,POLD2,UBA52,RFC4,RPA2,UBB
R-HSA-69236	G1 Phase	0.00293359700568593	-5.83152596190377	39	21	0.0065035614741406	3229	10285	5516,5925,902,1031,6233,7311,1163,1021,1874,5518,7029,7314,595,6500,1026,1022,4331,1019,896,1027,1032	PPP2CB,RB1,CCNH,CDKN2C,RPS27A,UBA52,CKS1B,CDK6,E2F4,PPP2R1A,TFDP2,UBB,CCND1,SKP1,CDKN1A,CDK7,MNAT1,CDK4,CCND3,CDKN1B,CDKN2D
R-HSA-69231	Cyclin D associated events in G1	0.00293359700568593	-5.83152596190377	39	21	0.0065035614741406	3229	10285	4331,1032,1027,896,1019,1026,6500,1022,595,7311,6233,7314,7029,5518,1874,1163,1021,5516,5925,1031,902	MNAT1,CDKN2D,CDKN1B,CCND3,CDK4,CDKN1A,SKP1,CDK7,CCND1,UBA52,RPS27A,UBB,TFDP2,PPP2R1A,E2F4,CKS1B,CDK6,PPP2CB,RB1,CDKN2C,CCNH
R-HSA-912526	Interleukin receptor SHC signaling	0.0030092546968505	-5.80606283990129	255	101	0.031279033756581	3229	10285	3845,5604,5908,5894,84292,27006,7311,1852,6714,10817,5716,2255,5686,8074,152559,4233,5037,5691,5529,6709,5296,3561,2246,5525,1848,7529,5682,5702,5245,5710,161742,6233,3562,5692,6464,25780,1843,7979,3567,28956,3815,5516,3265,5290,5687,8682,5690,5707,8649,818,3560,8823,5700,8452,7450,10213,5518,7314,5720,284,5536,6711,8822,5713,5699,122706,5705,2260,3558,5685,1445,8315,1742,5683,5694,5689,5295,3717,5695,3636,5709,5704,5693,5684,4296,11221,4747,1839,9861,5721,2248,3559,200734,5698,5906,53358,1437,8503,5718,3716,2252	KRAS,MAP2K1,RAP1B,RAF1,WDR83,FGF22,UBA52,DUSP9,SRC,FRS3,PSMD10,FGF10,PSMA5,FGF23,PAQR3,MET,PEBP1,PSMB3,PPP2R5E,SPTAN1,PIK3R2,IL2RG,FGF1,PPP2R5A,DUSP6,YWHAB,PSMA1,PSMC3,PHB1,PSMD4,SPRED1,RPS27A,IL3,PSMB4,SHC1,RASGRP3,DUSP1,SEM1,IL5,LAMTOR2,KIT,PPP2CB,HRAS,PIK3CA,PSMA6,PEA15,PSMB2,PSMD1,LAMTOR3,CAMK2G,IL2RB,FGF16,PSMC1,CUL3,VWF,PSMD14,PPP2R1A,UBB,PSME1,ANGPT1,PPP5C,SPTBN1,FGF17,PSMD7,PSMB10,PSMB11,PSMC5,FGFR1,IL2,PSMA4,CSK,BRAP,DLG4,PSMA2,PSMB6,PSMB1,PIK3R1,JAK2,PSMB7,INPPL1,PSMD3,PSMC4,PSMB5,PSMA3,MAP3K11,DUSP10,NEFL,HBEGF,PSMD6,PSME2,FGF3,IL2RA,SPRED2,PSMB9,RAP1A,SHC3,CSF2,PIK3R3,PSMD12,JAK1,FGF7
R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport	0.00307007582734421	-5.7860530182274	69	33	0.0102198823165067	3229	10285	51693,3998,10282,6396,79090,51399,6811,122553,5265,10652,10484,10175,10342,9554,9570,10113,26984,100313843,51128,966,8774,1075,23256,7109,81876,5861,58485,9117,27095,55014,2348,8775,2890	TRAPPC2L,LMAN1,BET1,SEC13,TRAPPC6A,TRAPPC4,STX5,TRAPPC6B,SERPINA1,YKT6,SEC23A,CNIH1,TFG,SEC22B,GOSR2,PREB,SEC22A,MIR711,SAR1B,CD59,NAPG,CTSC,SCFD1,TRAPPC10,RAB1B,RAB1A,TRAPPC1,SEC22C,TRAPPC3,STX17,FOLR1,NAPA,GRIA1
R-HSA-69190	DNA strand elongation	0.00307319572359844	-5.785037306486	32	18	0.00557448126354909	3229	10285	5111,2237,4173,5558,6118,4172,5984,4175,5425,5985,57804,84296,5982,64785,84515,6119,5983,23649	PCNA,FEN1,MCM4,PRIM2,RPA2,MCM3,RFC4,MCM6,POLD2,RFC5,POLD4,GINS4,RFC2,GINS3,MCM8,RPA3,RFC3,POLA2
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.00316643219490747	-5.75514981549855	443	166	0.0514091049860638	3229	10285	5716,10817,1852,6714,6375,1133,2255,5908,2147,5588,3845,5032,5604,84292,2782,7311,5997,27006,2767,5894,10235,2797,2911,5296,3561,1902,7529,10161,5525,2246,1848,152559,2787,23236,4233,5686,2790,8074,5529,51764,6709,3356,5691,5037,114814,6464,25780,5021,1128,5692,7979,1843,5702,2837,5682,4295,3562,6233,161742,5710,5245,8823,8649,818,2925,3560,2796,7450,5700,8452,3567,3265,2791,28956,3815,5516,9630,5707,5690,8682,5687,27334,5290,5536,8477,6711,284,5720,55970,553,54331,8822,5713,3060,10213,2788,1131,5578,5518,7314,10287,3717,5695,5709,1385,5689,387129,4829,5295,5693,5684,6863,5704,10911,5028,5685,5699,84539,6869,2260,3558,5705,122706,57406,5694,84432,5683,5737,8315,5330,1445,680,1742,5721,2248,26090,6368,1839,2847,9861,200734,3559,5698,4296,2840,1909,59345,148,4747,11221,6870,51738,1437,8503,5581,2784,2793,2252,5731,3716,5718,2776,9170,53358,2785,5906	PSMD10,FRS3,DUSP9,SRC,XCL1,CHRM5,FGF10,RAP1B,F2,PRKCQ,KRAS,P2RY11,MAP2K1,WDR83,GNB1,UBA52,RGS2,FGF22,GNA11,RAF1,RASGRP2,GNRH2,GRM1,PIK3R2,IL2RG,LPAR1,YWHAB,LPAR6,PPP2R5A,FGF1,DUSP6,PAQR3,GNG5,PLCB1,MET,PSMA5,GNG10,FGF23,PPP2R5E,GNG13,SPTAN1,HTR2A,PSMB3,PEBP1,GNRHR2,SHC1,RASGRP3,OXTR,CHRM1,PSMB4,SEM1,DUSP1,PSMC3,UTS2R,PSMA1,MLN,IL3,RPS27A,SPRED1,PSMD4,PHB1,FGF16,LAMTOR3,CAMK2G,GRPR,IL2RB,GNRH1,VWF,PSMC1,CUL3,IL5,HRAS,GNG11,LAMTOR2,KIT,PPP2CB,GNA14,PSMD1,PSMB2,PEA15,PSMA6,P2RY10,PIK3CA,PPP5C,GPR65,SPTBN1,ANGPT1,PSME1,GNG12,AVPR1B,GNG2,FGF17,PSMD7,HCRT,PSMD14,GNG7,CHRM3,PRKCA,PPP2R1A,UBB,RGS19,JAK2,PSMB7,PSMD3,CREB1,PSMB1,NPSR1,NMBR,PIK3R1,PSMB5,PSMA3,TAC1,PSMC4,UTS2,P2RY1,PSMA4,PSMB10,MCHR2,TACR1,FGFR1,IL2,PSMC5,PSMB11,ABHD6,PSMB6,PROK1,PSMA2,PTGFR,BRAP,PLCB2,CSK,BRS3,DLG4,PSME2,FGF3,ABHD12,CCL23,HBEGF,MCHR1,PSMD6,SPRED2,IL2RA,PSMB9,MAP3K11,GPR17,EDNRA,GNB4,ADRA1A,NEFL,DUSP10,TACR3,GHRL,CSF2,PIK3R3,PRKCE,GNB3,GNGT2,FGF7,PTGER1,JAK1,PSMD12,GNAQ,LPAR2,SHC3,GNG3,RAP1A
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.00326127454526739	-5.7256371952044	330	127	0.0393310622483741	3229	10285	3562,3685,6233,161742,5710,5245,5702,1499,857,5682,7979,1843,7422,25780,6464,5062,5692,1495,5690,5707,10787,10000,8682,5687,207,3320,5290,3315,3265,5516,3815,28956,3567,26999,7450,5700,8452,8823,3560,818,8649,7311,27006,84292,5894,5908,5604,3845,6093,2255,5716,10817,6714,9475,1852,6709,5529,5691,5037,4233,152559,8074,5686,998,7529,1848,5525,2246,3561,5296,3728,4747,11221,4296,5698,200734,3559,2248,5721,9861,1839,53358,5906,208,2252,3716,5718,5579,7867,1437,5567,5578,7314,5518,10213,4690,5713,8822,63916,6711,5536,9844,10810,284,5720,5694,5683,1742,8315,1445,5685,2260,5705,3558,122706,5699,5693,5684,7410,5704,5709,3717,5695,1500,5295,5689,10768	IL3,ITGAV,RPS27A,SPRED1,PSMD4,PHB1,PSMC3,CTNNB1,CAV1,PSMA1,SEM1,DUSP1,VEGFA,RASGRP3,SHC1,PAK2,PSMB4,CTNNA1,PSMB2,PSMD1,NCKAP1,AKT3,PEA15,PSMA6,AKT1,HSP90AA1,PIK3CA,HSPB1,HRAS,PPP2CB,KIT,LAMTOR2,IL5,CYFIP2,VWF,PSMC1,CUL3,FGF16,IL2RB,CAMK2G,LAMTOR3,UBA52,FGF22,WDR83,RAF1,RAP1B,MAP2K1,KRAS,ROCK1,FGF10,PSMD10,FRS3,SRC,ROCK2,DUSP9,SPTAN1,PPP2R5E,PSMB3,PEBP1,MET,PAQR3,FGF23,PSMA5,CDC42,YWHAB,DUSP6,PPP2R5A,FGF1,IL2RG,PIK3R2,JUP,NEFL,DUSP10,MAP3K11,PSMB9,SPRED2,IL2RA,FGF3,PSME2,PSMD6,HBEGF,SHC3,RAP1A,AKT2,FGF7,JAK1,PSMD12,PRKCB,MAPKAPK3,CSF2,PRKACB,PRKCA,UBB,PPP2R1A,PSMD14,NCK1,PSMD7,FGF17,ELMO2,SPTBN1,PPP5C,ELMO1,WASF3,ANGPT1,PSME1,PSMB6,PSMA2,DLG4,BRAP,CSK,PSMA4,FGFR1,PSMC5,IL2,PSMB11,PSMB10,PSMB5,PSMA3,VAV2,PSMC4,PSMD3,JAK2,PSMB7,CTNND1,PIK3R1,PSMB1,AHCYL1
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	0.0033273228217824	-5.70558725575957	23	14	0.00433570764942707	3229	10285	7311,81631,56993,6233,7314,8878,9868,9804,7416,54543,10452,84557,55669,100188893	UBA52,MAP1LC3B,TOMM22,RPS27A,UBB,SQSTM1,TOMM70,TOMM20,VDAC1,TOMM7,TOMM40,MAP1LC3A,MFN1,TOMM6
R-HSA-5205647	Mitophagy	0.0033273228217824	-5.70558725575957	23	14	0.00433570764942707	3229	10285	9804,9868,7416,54543,7311,56993,81631,6233,7314,8878,10452,84557,55669,100188893	TOMM20,TOMM70,VDAC1,TOMM7,UBA52,TOMM22,MAP1LC3B,RPS27A,UBB,SQSTM1,TOMM40,MAP1LC3A,MFN1,TOMM6
R-HSA-74752	Signaling by Insulin receptor	0.00352966935274803	-5.64655108020079	322	124	0.0384019820377826	3229	10285	5709,3717,5695,5295,5689,5684,5693,5704,5685,3558,5705,2260,122706,5699,5694,5683,1742,6009,8315,1445,6711,5536,284,5720,5713,9550,90423,8822,10213,5781,6794,7314,5518,51719,1437,533,2252,3716,55004,5718,208,1975,10670,53358,5906,2248,5721,9861,1839,5698,200734,3559,4296,10325,4747,11221,5296,3561,7529,2887,1848,5525,2246,55437,4233,152559,8074,5686,6709,54106,528,1977,5529,5691,5037,5716,10817,6714,1852,2255,5908,5604,3845,7311,8992,27006,84292,5894,8823,3560,818,8649,7450,5571,8452,5700,2549,3265,3815,28956,5516,3567,5707,5690,207,5687,8682,5290,534,25780,6464,5692,523,7979,51382,1843,5564,5702,5682,3562,6233,161742,5710,5245	PSMD3,JAK2,PSMB7,PIK3R1,PSMB1,PSMA3,PSMB5,PSMC4,PSMA4,IL2,PSMC5,FGFR1,PSMB11,PSMB10,PSMB6,PSMA2,DLG4,RHEB,BRAP,CSK,SPTBN1,PPP5C,ANGPT1,PSME1,PSMD7,ATP6V1G1,ATP6V1E2,FGF17,PSMD14,PTPN11,STK11,UBB,PPP2R1A,CAB39,CSF2,ATP6V0B,FGF7,JAK1,LAMTOR1,PSMD12,AKT2,EIF4B,RRAGA,SHC3,RAP1A,FGF3,PSME2,PSMD6,HBEGF,PSMB9,SPRED2,IL2RA,MAP3K11,RRAGB,NEFL,DUSP10,PIK3R2,IL2RG,YWHAB,GRB10,DUSP6,PPP2R5A,FGF1,STRADB,MET,PAQR3,FGF23,PSMA5,SPTAN1,TLR9,ATP6V1C1,EIF4E,PPP2R5E,PSMB3,PEBP1,PSMD10,FRS3,SRC,DUSP9,FGF10,RAP1B,MAP2K1,KRAS,UBA52,ATP6V0E1,FGF22,WDR83,RAF1,FGF16,IL2RB,CAMK2G,LAMTOR3,VWF,PRKAG1,CUL3,PSMC1,GAB1,HRAS,KIT,LAMTOR2,PPP2CB,IL5,PSMD1,PSMB2,AKT1,PSMA6,PEA15,PIK3CA,ATP6V1G2,RASGRP3,SHC1,PSMB4,ATP6V1A,SEM1,ATP6V1D,DUSP1,PRKAB1,PSMC3,PSMA1,IL3,RPS27A,SPRED1,PSMD4,PHB1
R-HSA-451927	Interleukin-2 signaling	0.00361250073262845	-5.62335502273988	262	103	0.031898420563642	3229	10285	5698,3559,200734,9861,1839,2248,5721,4747,11221,4296,5718,2252,3716,8503,1437,5906,53358,5713,8822,284,5720,6711,5536,7314,5518,6776,10213,5704,5684,5693,5295,5689,5709,3636,3717,5695,1742,8315,1445,5683,5694,2260,5705,3558,122706,5699,5685,1843,7979,5692,6464,25780,161742,5710,5245,3562,6233,5682,5702,8452,5700,7450,3560,8649,818,8823,5687,8682,5290,5690,5707,3265,28956,5516,3815,3567,2255,6714,1852,5716,10817,5894,7311,6850,27006,84292,5604,3845,5908,1848,5525,2246,7529,3561,5296,5691,5037,6709,5529,8074,5686,4233,152559	PSMB9,IL2RA,SPRED2,PSMD6,HBEGF,FGF3,PSME2,NEFL,DUSP10,MAP3K11,PSMD12,FGF7,JAK1,PIK3R3,CSF2,RAP1A,SHC3,PSMD7,FGF17,ANGPT1,PSME1,SPTBN1,PPP5C,UBB,PPP2R1A,STAT5A,PSMD14,PSMC4,PSMA3,PSMB5,PIK3R1,PSMB1,PSMD3,INPPL1,JAK2,PSMB7,DLG4,BRAP,CSK,PSMA2,PSMB6,FGFR1,PSMC5,IL2,PSMB11,PSMB10,PSMA4,DUSP1,SEM1,PSMB4,SHC1,RASGRP3,SPRED1,PSMD4,PHB1,IL3,RPS27A,PSMA1,PSMC3,CUL3,PSMC1,VWF,IL2RB,LAMTOR3,CAMK2G,FGF16,PSMA6,PEA15,PIK3CA,PSMB2,PSMD1,HRAS,LAMTOR2,PPP2CB,KIT,IL5,FGF10,SRC,DUSP9,PSMD10,FRS3,RAF1,UBA52,SYK,FGF22,WDR83,MAP2K1,KRAS,RAP1B,DUSP6,PPP2R5A,FGF1,YWHAB,IL2RG,PIK3R2,PSMB3,PEBP1,SPTAN1,PPP2R5E,FGF23,PSMA5,MET,PAQR3
R-HSA-76002	Platelet activation, signaling and aggregation	0.00361920945688091	-5.62149965907039	282	110	0.0340662743883555	3229	10285	10447,2815,7450,3560,54495,10000,2773,207,5290,7043,7078,7018,9630,3567,388,2791,7422,7114,6464,406974,5919,3562,928,1072,5770,3309,51571,391,5627,998,5340,10184,55664,3561,5296,66005,10916,51764,2790,2207,2787,12,6647,5478,7534,6714,54863,948,2767,10235,5894,2782,813,6850,78991,5908,80739,2147,51706,5588,2771,3716,29106,1437,8503,5579,10490,2784,5581,2793,29789,6414,2785,5906,1191,208,2776,23052,5880,3559,213,26090,64805,967,81,59345,5552,7410,51368,5295,3920,3717,5294,1445,57406,8407,3558,5028,7424,54331,54676,55970,3937,5578,3479,5265,5781,2788,7076,7042	FAM3C,GP9,VWF,IL2RB,TMX3,AKT3,GNAI3,AKT1,PIK3CA,TGFB3,TIMP3,TF,GNA14,IL5,RHOB,GNG11,VEGFA,TMSB4X,SHC1,MIR197,RARRES2,IL3,CD9,CFL1,PTPN1,HSPA5,CYRIB,RHOG,PROS1,CDC42,PLG,LHFPL2,CDC37L1,IL2RG,PIK3R2,CHID1,MAGED2,GNG13,GNG10,FCER1G,GNG5,SERPINA3,SOD1,PPIA,YWHAZ,SRC,TOR4A,CD36,GNA11,RASGRP2,RAF1,GNB1,CALU,SYK,PCYOX1L,RAP1B,MPIG6B,F2,CYB5R1,PRKCQ,GNAI2,JAK1,SCG3,CSF2,PIK3R3,PRKCB,VTI1B,GNB3,PRKCE,GNGT2,OLA1,SELENOP,GNG3,RAP1A,CLU,AKT2,GNAQ,ENDOD1,RAC2,IL2RA,ALB,ABHD12,P2RY12,CD63,ACTN4,GNB4,SRGN,VAV2,TEX264,PIK3R1,LAMP2,JAK2,PIK3CG,CSK,ABHD6,TAGLN2,IL2,P2RY1,VEGFC,GNG2,GTPBP2,GNG12,LCP2,PRKCA,IGF1,SERPINA1,PTPN11,GNG7,TIMP1,TGFB2
R-HSA-2871796	FCERI mediated MAPK activation	0.00368685441930041	-5.60298164537531	265	104	0.0322081139671725	3229	10285	5718,3716,5602,2252,1437,5906,53358,200734,3559,5698,1839,9861,5721,2248,11221,4747,9402,4296,5704,7410,2353,5693,5684,5689,3717,5695,5709,1445,8315,1742,5694,5683,5699,122706,3725,2260,5705,3558,5685,8822,5713,5720,284,5536,6711,5518,7314,3937,10213,5700,8452,7450,818,8649,3560,8823,8682,5687,5707,5690,3567,5516,3815,28956,3265,1843,7979,5692,5062,6464,25780,5245,5710,161742,6233,3562,5682,5702,2246,5525,1848,7529,3561,5037,5691,5529,6709,5686,8074,152559,4233,2255,1852,6714,10817,5716,5894,84292,6850,27006,7311,3845,5604,5908	PSMD12,JAK1,MAPK10,FGF7,CSF2,RAP1A,SHC3,SPRED2,IL2RA,PSMB9,HBEGF,PSMD6,PSME2,FGF3,DUSP10,NEFL,GRAP2,MAP3K11,PSMC4,VAV2,FOS,PSMB5,PSMA3,PSMB1,JAK2,PSMB7,PSMD3,CSK,BRAP,DLG4,PSMB6,PSMA2,PSMB10,PSMB11,JUN,FGFR1,PSMC5,IL2,PSMA4,FGF17,PSMD7,PSME1,ANGPT1,PPP5C,SPTBN1,PPP2R1A,UBB,LCP2,PSMD14,PSMC1,CUL3,VWF,CAMK2G,LAMTOR3,IL2RB,FGF16,PEA15,PSMA6,PSMD1,PSMB2,IL5,PPP2CB,KIT,LAMTOR2,HRAS,DUSP1,SEM1,PSMB4,PAK2,SHC1,RASGRP3,PHB1,PSMD4,SPRED1,RPS27A,IL3,PSMA1,PSMC3,FGF1,PPP2R5A,DUSP6,YWHAB,IL2RG,PEBP1,PSMB3,PPP2R5E,SPTAN1,PSMA5,FGF23,PAQR3,MET,FGF10,DUSP9,SRC,FRS3,PSMD10,RAF1,WDR83,SYK,FGF22,UBA52,KRAS,MAP2K1,RAP1B
R-HSA-112315	Transmission across Chemical Synapses	0.00380207217527742	-5.57220905159334	217	87	0.0269433261071539	3229	10285	1141,54331,27020,6539,55970,7102,6531,5894,5578,5567,2782,2550,3312,81539,3760,140679,2788,6507,1139,4646,2890,109,9463,6804,4193,8541,2566,6529,5864,1385,6616,5330,2561,1742,2897,108,51764,3759,160,2790,2787,23236,55327,1312,3766,1741,785,80331,2562,8499,406974,2555,6505,4747,64130,10815,2554,6506,1739,43,83988,2752,59345,10550,8573,8224,10368,2891,2771,818,2793,2784,6812,5579,2572,784,2773,2785,6844,6532,1173,783,6538,54407,1175,2791,3265	CHRNB2,GNG2,NPTN,SLC6A12,GNG12,TSPAN7,SLC6A3,RAF1,PRKCA,PRKACB,GNB1,GABBR1,HSPA8,SLC38A1,KCNJ3,SLC32A1,GNG7,SLC1A3,CHRNA7,MYO6,GRIA1,ADCY3,PICK1,STX1A,MDM2,PPFIA3,GABRG2,SLC6A1,RAB3A,CREB1,SNAP25,PLCB2,GABRB2,DLG4,GRIK1,ADCY2,GNG13,KCNJ2,AP2A1,GNG10,GNG5,PLCB1,LIN7C,COMT,KCNJ10,DLG3,CACNB4,DNAJC5,GABRB3,PPFIA2,MIR197,GABRA2,SLC1A1,NEFL,LIN7B,CPLX1,GABRA1,SLC1A2,DLG1,ACHE,NCALD,GLUL,GNB4,ARL6IP5,CASK,SYN3,CACNG3,GRIA2,GNAI2,CAMK2G,GNGT2,GNB3,STXBP1,PRKCB,GAD2,CACNB3,GNAI3,GNG3,VAMP2,SLC6A4,AP2M1,CACNB2,SLC6A11,SLC38A2,AP2S1,GNG11,HRAS
R-HSA-933541	TRAF6 mediated IRF7 activation	0.0040717488705196	-5.50368267390498	35	19	0.00588417466707959	3229	10285	3440,7186,3665,10010,80143,57506,3447,3659,7189,64135,23586,3661,3446,1387,2033,3660,29110,3456,4615	IFNA2,TRAF2,IRF7,TANK,SIKE1,MAVS,IFNA13,IRF1,TRAF6,IFIH1,RIGI,IRF3,IFNA10,CREBBP,EP300,IRF2,TBK1,IFNB1,MYD88
R-HSA-113418	Formation of the Early Elongation Complex	0.0040717488705196	-5.50368267390498	35	19	0.00588417466707959	3229	10285	1022,4331,2071,6829,5431,22916,5435,902,5432,5436,6827,2968,2963,2962,2966,5433,404672,5441,5438	CDK7,MNAT1,ERCC3,SUPT5H,POLR2B,NCBP2,POLR2F,CCNH,POLR2C,POLR2G,SUPT4H1,GTF2H4,GTF2F2,GTF2F1,GTF2H2,POLR2D,GTF2H5,POLR2L,POLR2I
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.0040717488705196	-5.50368267390498	35	19	0.00588417466707959	3229	10285	5435,2968,2963,5436,902,5432,6827,5433,404672,5438,5441,2966,2962,1022,4331,5431,22916,2071,6829	POLR2F,GTF2H4,GTF2F2,POLR2G,CCNH,POLR2C,SUPT4H1,POLR2D,GTF2H5,POLR2I,POLR2L,GTF2H2,GTF2F1,CDK7,MNAT1,POLR2B,NCBP2,ERCC3,SUPT5H
R-HSA-194138	Signaling by VEGF	0.00425844838031853	-5.45885041502088	338	129	0.0399504490554351	3229	10285	63916,8822,5713,4690,10810,284,5720,9844,5536,6711,5518,7314,5578,5567,10213,5704,7410,5693,5684,5689,10768,1500,5295,5695,3717,5709,8315,1445,1742,5694,5683,5699,3558,5705,2260,122706,5685,7424,200734,3559,5698,1839,9861,5721,2248,3728,4747,11221,4296,5718,2252,3716,7867,1437,5579,5906,53358,208,6093,2255,1852,6714,9475,5716,10817,5894,84292,7311,27006,3845,5604,5908,5525,2246,1848,998,7529,5296,3561,5691,5037,5529,6709,5686,8074,152559,4233,7422,1843,7979,5692,1495,5062,25780,6464,161742,5245,5710,3562,3685,6233,857,5682,1499,5702,5700,8452,7450,818,8649,3560,8823,8682,207,10000,5687,3320,5290,3315,8829,10787,5707,5690,26999,3567,3265,28956,5516,3815	ELMO2,FGF17,PSMD7,NCK1,WASF3,ANGPT1,PSME1,ELMO1,PPP5C,SPTBN1,PPP2R1A,UBB,PRKCA,PRKACB,PSMD14,PSMC4,VAV2,PSMB5,PSMA3,PSMB1,AHCYL1,CTNND1,PIK3R1,PSMB7,JAK2,PSMD3,BRAP,CSK,DLG4,PSMB6,PSMA2,PSMB10,IL2,PSMC5,FGFR1,PSMB11,PSMA4,VEGFC,SPRED2,IL2RA,PSMB9,HBEGF,PSMD6,PSME2,FGF3,JUP,NEFL,DUSP10,MAP3K11,PSMD12,FGF7,JAK1,MAPKAPK3,CSF2,PRKCB,RAP1A,SHC3,AKT2,ROCK1,FGF10,DUSP9,SRC,ROCK2,PSMD10,FRS3,RAF1,WDR83,UBA52,FGF22,KRAS,MAP2K1,RAP1B,PPP2R5A,FGF1,DUSP6,CDC42,YWHAB,PIK3R2,IL2RG,PSMB3,PEBP1,PPP2R5E,SPTAN1,PSMA5,FGF23,PAQR3,MET,VEGFA,DUSP1,SEM1,PSMB4,CTNNA1,PAK2,RASGRP3,SHC1,SPRED1,PHB1,PSMD4,IL3,ITGAV,RPS27A,CAV1,PSMA1,CTNNB1,PSMC3,PSMC1,CUL3,VWF,CAMK2G,LAMTOR3,IL2RB,FGF16,PEA15,AKT1,AKT3,PSMA6,HSP90AA1,PIK3CA,HSPB1,NRP1,NCKAP1,PSMD1,PSMB2,CYFIP2,IL5,HRAS,LAMTOR2,PPP2CB,KIT
R-HSA-110320	Translesion Synthesis by POLH	0.00427372311046064	-5.45526990882099	19	12	0.00371632084236606	3229	10285	6118,7314,5984,7311,6233,5111,7353,5983,5985,25898,5982,6119	RPA2,UBB,RFC4,UBA52,RPS27A,PCNA,UFD1,RFC3,RFC5,RCHY1,RFC2,RPA3
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	0.00427372311046064	-5.45526990882099	19	12	0.00371632084236606	3229	10285	2791,2787,59345,2790,2788,51764,2782,2785,2784,2793,55970,54331	GNG11,GNG5,GNB4,GNG10,GNG7,GNG13,GNB1,GNG3,GNB3,GNGT2,GNG12,GNG2
R-HSA-187706	Signalling to p38 via RIT and RIN	0.00428347063966516	-5.45299170086984	249	98	0.0303499535459895	3229	10285	3561,7529,2246,5525,1848,152559,4233,5686,8074,5529,6709,5037,5691,10817,5716,1852,6714,2255,5908,3845,5604,84292,27006,7311,6016,5894,8823,8649,818,3560,7450,8452,5700,3567,3815,5516,28956,3265,5707,5690,8682,5687,25780,6464,5692,7979,1843,5702,5682,6233,3562,5245,5710,161742,3717,5695,5709,5689,5693,5684,5704,5685,5699,122706,2260,3558,5705,5683,5694,1445,8315,1742,5536,6014,6711,5720,284,8822,5713,10213,5518,7314,1437,3716,2252,5718,53358,5906,5721,2248,1839,9861,3559,200734,5698,4296,11221,4747	IL2RG,YWHAB,FGF1,PPP2R5A,DUSP6,PAQR3,MET,PSMA5,FGF23,PPP2R5E,SPTAN1,PEBP1,PSMB3,FRS3,PSMD10,DUSP9,SRC,FGF10,RAP1B,KRAS,MAP2K1,WDR83,FGF22,UBA52,RIT1,RAF1,FGF16,LAMTOR3,CAMK2G,IL2RB,VWF,CUL3,PSMC1,IL5,KIT,PPP2CB,LAMTOR2,HRAS,PSMD1,PSMB2,PEA15,PSMA6,RASGRP3,SHC1,PSMB4,SEM1,DUSP1,PSMC3,PSMA1,RPS27A,IL3,PHB1,PSMD4,SPRED1,JAK2,PSMB7,PSMD3,PSMB1,PSMB5,PSMA3,PSMC4,PSMA4,PSMB10,PSMB11,FGFR1,IL2,PSMC5,PSMA2,PSMB6,CSK,BRAP,DLG4,PPP5C,RIT2,SPTBN1,PSME1,ANGPT1,FGF17,PSMD7,PSMD14,PPP2R1A,UBB,CSF2,JAK1,FGF7,PSMD12,SHC3,RAP1A,PSME2,FGF3,HBEGF,PSMD6,IL2RA,SPRED2,PSMB9,MAP3K11,DUSP10,NEFL
R-HSA-913531	Interferon Signaling	0.00435575011774307	-5.43625844062962	201	81	0.0250851656859709	3229	10285	81603,3433,3665,11097,3394,3383,7341,5495,6772,57122,9775,6041,79023,3669,818,5610,3838,684,3661,2209,3446,3716,1974,3664,23650,7334,4502,3454,10346,80128,54739,5770,129401,6233,1958,3459,9470,117854,85363,3429,10107,23586,23636,7726,9972,3456,10379,3440,567,1977,2537,25939,4938,3458,3430,6737,3447,3717,55223,9021,4600,10762,9636,3660,53840,23087,6773,3662,5781,7311,91543,10612,80263,7314,3659,317649,8554,3836,5371,55128,4599	TRIM8,IFIT2,IRF7,NUP42,IRF8,ICAM1,SUMO1,PPM1B,STAT1,NUP107,EIF4A3,RNASEL,NUP37,ISG20,CAMK2G,EIF2AK2,KPNA2,BST2,IRF3,FCGR1A,IFNA10,JAK1,EIF4A2,IRF6,TRIM29,UBE2N,MT2A,IFNAR1,TRIM22,TRIM46,XAF1,PTPN1,NUP35,RPS27A,EGR1,IFNGR1,EIF4E2,TRIM6,TRIM5,IFI27,TRIM10,RIGI,NUP62,TRIM26,NUP153,IFNB1,IRF9,IFNA2,B2M,EIF4E,IFI6,SAMHD1,OAS1,IFNG,IFI35,TRIM21,IFNA13,JAK2,TRIM62,SOCS3,MX2,NUP50,ISG15,IRF2,TRIM34,TRIM35,STAT2,IRF4,PTPN11,UBA52,RSAD2,TRIM3,TRIM45,UBB,IRF1,EIF4E3,PIAS1,KPNA1,PML,TRIM68,MX1
R-HSA-5656121	Translesion synthesis by POLI	0.00477284229864126	-5.34481328180565	17	11	0.00340662743883555	3229	10285	10459,6233,7311,5984,5983,7314,6118,6119,5111,5982,5985	MAD2L2,RPS27A,UBA52,RFC4,RFC3,UBB,RPA2,RPA3,PCNA,RFC2,RFC5
R-HSA-5655862	Translesion synthesis by POLK	0.00477284229864126	-5.34481328180565	17	11	0.00340662743883555	3229	10285	5983,5984,7314,6118,10459,6233,7311,5985,6119,5982,5111	RFC3,RFC4,UBB,RPA2,MAD2L2,RPS27A,UBA52,RFC5,RPA3,RFC2,PCNA
R-HSA-1839126	FGFR2 mutant receptor activation	0.00479784765273344	-5.33958786731272	33	18	0.00557448126354909	3229	10285	8823,2248,2252,22916,5431,2255,8822,2246,5435,8074,2963,5436,5432,27006,5438,5441,5433,2962	FGF16,FGF3,FGF7,NCBP2,POLR2B,FGF10,FGF17,FGF1,POLR2F,FGF23,GTF2F2,POLR2G,POLR2C,FGF22,POLR2I,POLR2L,POLR2D,GTF2F1
R-HSA-2172127	DAP12 interactions	0.00480605414952397	-5.33787887466434	371	140	0.0433570764942707	3229	10285	5604,3845,5908,5894,57690,7311,27006,6850,84292,6714,1852,5716,10817,2255,118788,4343,8074,5686,5728,4233,152559,5691,5037,5136,6709,5529,8394,29851,3561,5296,1848,5525,2246,4193,7529,942,5682,7157,5702,161742,5245,5710,3562,6233,5692,25780,6464,1843,3822,7979,79837,3265,2549,3815,28956,5516,3567,207,5687,10000,8682,5290,5690,5707,3560,818,8649,8823,5700,8452,8870,7450,5781,10213,3937,7314,5518,5578,5567,284,5720,5153,6711,26523,5536,5713,941,8822,3558,7305,5705,2260,122706,5699,567,3824,5685,940,1742,8315,1445,5694,5683,108,5295,5689,10768,1385,5709,3717,5695,1027,5704,5684,5693,7410,109,9402,2931,572,4296,4747,11221,9861,1839,2248,5721,5698,200734,3559,208,5906,53358,8503,5581,1026,1437,5718,2252,3716	MAP2K1,KRAS,RAP1B,RAF1,TNRC6C,UBA52,FGF22,SYK,WDR83,SRC,DUSP9,PSMD10,FRS3,FGF10,PIK3AP1,MOV10,FGF23,PSMA5,PTEN,MET,PAQR3,PSMB3,PEBP1,PDE1A,SPTAN1,PPP2R5E,PIP5K1A,ICOS,IL2RG,PIK3R2,DUSP6,PPP2R5A,FGF1,MDM2,YWHAB,CD86,PSMA1,TP53,PSMC3,SPRED1,PHB1,PSMD4,IL3,RPS27A,PSMB4,RASGRP3,SHC1,DUSP1,KLRC2,SEM1,PIP4K2C,HRAS,GAB1,KIT,LAMTOR2,PPP2CB,IL5,AKT1,PSMA6,AKT3,PEA15,PIK3CA,PSMB2,PSMD1,IL2RB,CAMK2G,LAMTOR3,FGF16,PSMC1,CUL3,IER3,VWF,PTPN11,PSMD14,LCP2,UBB,PPP2R1A,PRKCA,PRKACB,ANGPT1,PSME1,PDE1B,SPTBN1,AGO1,PPP5C,PSMD7,CD80,FGF17,IL2,TYROBP,PSMC5,FGFR1,PSMB11,PSMB10,B2M,KLRD1,PSMA4,CD28,DLG4,BRAP,CSK,PSMB6,PSMA2,ADCY2,PIK3R1,PSMB1,AHCYL1,CREB1,PSMD3,JAK2,PSMB7,CDKN1B,PSMC4,PSMA3,PSMB5,VAV2,ADCY3,GRAP2,GSK3A,BAD,MAP3K11,NEFL,DUSP10,PSMD6,HBEGF,FGF3,PSME2,PSMB9,SPRED2,IL2RA,AKT2,RAP1A,SHC3,PIK3R3,PRKCE,CDKN1A,CSF2,PSMD12,FGF7,JAK1
R-HSA-171319	Telomere Extension By Telomerase	0.00488602952703664	-5.32137526297274	7	6	0.00185816042118303	3229	10285	10856,7015,8607,1736,55651,55135	RUVBL2,TERT,RUVBL1,DKC1,NHP2,WRAP53
R-HSA-2393930	Phosphate bond hydrolysis by NUDT proteins	0.00488602952703664	-5.32137526297274	7	6	0.00185816042118303	3229	10285	79873,56985,11164,4521,131870,53343	NUDT18,ADPRM,NUDT5,NUDT1,NUDT16,NUDT9
R-HSA-1226099	Signaling by FGFR in disease	0.00502659658566268	-5.29301214701192	63	30	0.00929080210591514	3229	10285	5431,22916,7750,8822,2255,2248,8805,26127,5433,5441,27006,11160,6776,5435,2963,5436,3845,2252,2246,8823,5295,5438,2962,5290,6772,3265,2549,2260,8074,5432	POLR2B,NCBP2,ZMYM2,FGF17,FGF10,FGF3,TRIM24,FGFR1OP2,POLR2D,POLR2L,FGF22,ERLIN2,STAT5A,POLR2F,GTF2F2,POLR2G,KRAS,FGF7,FGF1,FGF16,PIK3R1,POLR2I,GTF2F1,PIK3CA,STAT1,HRAS,GAB1,FGFR1,FGF23,POLR2C
R-HSA-446219	Synthesis of substrates in N-glycan biosythesis	0.00502659658566268	-5.29301214701192	63	30	0.00929080210591514	3229	10285	2673,29926,8869,140838,256435,10559,7264,6482,79644,4597,5373,55907,8818,4758,6675,5476,7903,8790,6480,6484,22845,29925,116150,55343,29880,2762,29906,64841,6483,26503	GFPT1,GMPPA,ST3GAL5,NANP,ST6GALNAC3,SLC35A1,GFUS,ST3GAL1,SRD5A3,MVD,PMM2,CMAS,DPM2,NEU1,UAP1,CTSA,ST8SIA4,FPGT,ST6GAL1,ST3GAL4,DOLK,GMPPB,NUS1,SLC35C1,ALG5,GMDS,ST8SIA5,GNPNAT1,ST3GAL2,SLC17A5
R-HSA-5358351	Signaling by Hedgehog	0.00516183232926279	-5.26646365995235	138	58	0.0179622174047693	3229	10285	51684,57154,51098,2622,57728,8405,5707,5690,5687,1452,79577,26160,23322,5700,8452,5718,5702,5682,6233,84455,5710,5721,5692,9861,7979,5698,5685,7289,5686,5699,5705,122706,55081,108,5694,5683,5691,5695,5709,5689,10956,109,5684,64399,5693,5704,27248,51009,10213,5567,7311,7314,84447,5716,5720,339745,6500,5713	SUFU,SMURF1,IFT52,GAS8,WDR19,SPOP,PSMD1,PSMB2,PSMA6,CSNK1A1,CDC73,IFT172,RPGRIP1L,PSMC1,CUL3,PSMD12,PSMC3,PSMA1,RPS27A,EFCAB7,PSMD4,PSME2,PSMB4,PSMD6,SEM1,PSMB9,PSMA4,TULP3,PSMA5,PSMB10,PSMC5,PSMB11,IFT57,ADCY2,PSMB6,PSMA2,PSMB3,PSMB7,PSMD3,PSMB1,OS9,ADCY3,PSMA3,HHIP,PSMB5,PSMC4,ERLEC1,DERL2,PSMD14,PRKACB,UBA52,UBB,SYVN1,PSMD10,PSME1,SPOPL,SKP1,PSMD7
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.00516845121412938	-5.2651822070775	38	20	0.0061938680706101	3229	10285	6647,2876,257202,6648,318,2877,2882,5052,2950,9973,2878,7001,2880,10587,10935,6649,7295,30001,9588,7296	SOD1,GPX1,GPX6,SOD2,NUDT2,GPX2,GPX7,PRDX1,GSTP1,CCS,GPX3,PRDX2,GPX5,TXNRD2,PRDX3,SOD3,TXN,ERO1A,PRDX6,TXNRD1
R-HSA-68886	M Phase	0.00527786192418744	-5.24423420187461	308	118	0.0365438216165996	3229	10285	7314,10051,5518,246184,5578,10213,5925,140609,85236,5713,983,5720,79980,8970,5694,5683,7112,9184,122706,5705,5699,8815,147841,5685,8348,5704,5693,5684,5861,991,81876,10762,8350,5689,5709,220134,8881,1460,5695,79003,91754,5862,129401,8345,255626,1457,348235,8331,5698,9972,29882,9861,25906,79019,7321,5721,57122,7514,22919,55766,401541,3014,10776,5718,891,3015,119504,5579,94239,3013,79023,7443,4000,7311,6396,5885,5048,5716,8342,5691,5529,5686,5525,332,23592,54820,5710,4001,51529,5501,6233,8334,5682,5702,8335,26003,9232,29945,91687,619553,23636,83540,7979,8697,5692,4085,79648,5687,5690,5707,11097,3796,5516,5700,10403,54892,474382,80776	UBB,SMC4,PPP2R1A,CDC26,PRKCA,PSMD14,RB1,NEK7,H2BC12,PSMD7,CDK1,PSME1,DSN1,H2BC11,PSMB6,PSMA2,TMPO,BUB3,PSMB11,PSMC5,PSMB10,BANF1,SPC24,PSMA4,H2BC17,PSMC4,PSMB5,PSMA3,RAB1A,CDC20,RAB1B,NUP50,H3C1,PSMB1,PSMD3,SKA1,CDC16,CSNK2B,PSMB7,MIS12,NEK9,RAB2A,NUP35,H2BC9,H2BC1,CSNK2A1,SKA2,H2AC14,PSMB9,NUP153,ANAPC2,PSMD6,ANAPC15,CENPM,UBE2D1,PSME2,NUP107,XPO1,MAPRE1,H2AJ,CENPP,H2AX,ARPP19,PSMD12,CCNB1,H2AZ1,ANAPC16,PRKCB,H2AZ2,H2AC7,NUP37,VRK1,LMNA,UBA52,SEC13,RAD21,PAFAH1B1,PSMD10,H2BC14,PSMB3,PPP2R5E,PSMA5,PPP2R5A,BIRC5,LEMD3,NDE1,PSMD4,LMNB1,ANAPC11,PPP1CC,RPS27A,H2AC6,PSMA1,PSMC3,H2AC4,GORASP2,PTTG1,ANAPC4,CENPL,MIR484,NUP62,NUF2,SEM1,CDC23,PSMB4,MAD2L1,MCPH1,PSMA6,PSMB2,PSMD1,NUP42,KIF2A,PPP2CB,PSMC1,NDC80,NCAPG2,H2AB1,B9D2
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.0053551719261029	-5.22969246988297	43	22	0.00681325487767111	3229	10285	902,2968,7336,7341,10038,7314,6118,2966,5887,6233,7311,404672,8554,1022,6119,6612,2071,6613,7334,1069,7329,4331	CCNH,GTF2H4,UBE2V2,SUMO1,PARP2,UBB,RPA2,GTF2H2,RAD23B,RPS27A,UBA52,GTF2H5,PIAS1,CDK7,RPA3,SUMO3,ERCC3,SUMO2,UBE2N,CETN2,UBE2I,MNAT1
R-HSA-179812	GRB2 events in EGFR signaling	0.00540312728249847	-5.22077736665227	245	96	0.0297305667389285	3229	10285	3567,3265,28956,5516,3815,8682,5687,5690,5707,8649,818,3560,8823,8452,5700,7450,5682,5702,161742,5710,5245,3562,6233,5692,6464,25780,1843,7979,5686,8074,152559,4233,5691,5037,5529,6709,3561,5525,2246,1848,7529,3845,5604,5908,5894,84292,7311,27006,1852,6714,5716,10817,2255,5906,53358,1437,5718,2252,3716,4296,4747,11221,1839,9861,5721,2248,3559,200734,5698,5699,3558,5705,2260,122706,5685,8315,1445,1742,5694,5683,5689,3717,5695,5709,5704,5693,5684,10213,5518,7314,284,5720,5536,6711,8822,5713	IL5,HRAS,LAMTOR2,PPP2CB,KIT,PEA15,PSMA6,PSMB2,PSMD1,LAMTOR3,CAMK2G,IL2RB,FGF16,CUL3,PSMC1,VWF,PSMA1,PSMC3,SPRED1,PSMD4,PHB1,IL3,RPS27A,PSMB4,SHC1,RASGRP3,DUSP1,SEM1,PSMA5,FGF23,PAQR3,MET,PSMB3,PEBP1,PPP2R5E,SPTAN1,IL2RG,PPP2R5A,FGF1,DUSP6,YWHAB,KRAS,MAP2K1,RAP1B,RAF1,WDR83,UBA52,FGF22,DUSP9,SRC,PSMD10,FRS3,FGF10,RAP1A,SHC3,CSF2,PSMD12,FGF7,JAK1,MAP3K11,NEFL,DUSP10,HBEGF,PSMD6,PSME2,FGF3,IL2RA,SPRED2,PSMB9,PSMB10,IL2,PSMC5,FGFR1,PSMB11,PSMA4,BRAP,CSK,DLG4,PSMB6,PSMA2,PSMB1,JAK2,PSMB7,PSMD3,PSMC4,PSMB5,PSMA3,PSMD14,PPP2R1A,UBB,ANGPT1,PSME1,PPP5C,SPTBN1,FGF17,PSMD7
R-HSA-180336	SHC1 events in EGFR signaling	0.00540312728249847	-5.22077736665227	245	96	0.0297305667389285	3229	10285	7450,8452,5700,8823,818,8649,3560,5707,5690,5687,8682,3567,3265,3815,28956,5516,7979,1843,25780,6464,5692,3562,6233,161742,5710,5245,5702,5682,7529,5525,2246,1848,3561,5529,6709,5691,5037,152559,4233,5686,8074,2255,5716,10817,1852,6714,84292,7311,27006,5894,5908,3845,5604,2252,3716,5718,1437,53358,5906,3559,200734,5698,5721,2248,1839,9861,4747,11221,4296,5693,5684,5704,5695,3717,5709,5689,5683,5694,8315,1445,1742,5685,5699,3558,5705,2260,122706,8822,5713,5536,6711,284,5720,5518,7314,10213	VWF,CUL3,PSMC1,FGF16,CAMK2G,LAMTOR3,IL2RB,PSMD1,PSMB2,PSMA6,PEA15,IL5,HRAS,KIT,LAMTOR2,PPP2CB,SEM1,DUSP1,RASGRP3,SHC1,PSMB4,IL3,RPS27A,SPRED1,PSMD4,PHB1,PSMC3,PSMA1,YWHAB,PPP2R5A,FGF1,DUSP6,IL2RG,PPP2R5E,SPTAN1,PSMB3,PEBP1,PAQR3,MET,PSMA5,FGF23,FGF10,PSMD10,FRS3,DUSP9,SRC,WDR83,UBA52,FGF22,RAF1,RAP1B,KRAS,MAP2K1,FGF7,JAK1,PSMD12,CSF2,SHC3,RAP1A,IL2RA,SPRED2,PSMB9,PSME2,FGF3,HBEGF,PSMD6,NEFL,DUSP10,MAP3K11,PSMB5,PSMA3,PSMC4,PSMB7,JAK2,PSMD3,PSMB1,PSMA2,PSMB6,BRAP,CSK,DLG4,PSMA4,PSMB10,IL2,PSMC5,FGFR1,PSMB11,FGF17,PSMD7,PPP5C,SPTBN1,ANGPT1,PSME1,PPP2R1A,UBB,PSMD14
R-HSA-5673001	RAF/MAP kinase cascade	0.00540312728249847	-5.22077736665227	245	96	0.0297305667389285	3229	10285	3561,7529,1848,5525,2246,4233,152559,8074,5686,6709,5529,5691,5037,5716,10817,6714,1852,2255,5908,5604,3845,7311,27006,84292,5894,8823,3560,8649,818,7450,5700,8452,3265,3815,5516,28956,3567,5690,5707,5687,8682,25780,6464,5692,7979,1843,5702,5682,3562,6233,161742,5245,5710,5709,3717,5695,5689,5693,5684,5704,5685,2260,3558,5705,122706,5699,5683,5694,1742,8315,1445,6711,5536,284,5720,5713,8822,10213,7314,5518,1437,2252,3716,5718,53358,5906,2248,5721,9861,1839,5698,200734,3559,4296,4747,11221	IL2RG,YWHAB,DUSP6,PPP2R5A,FGF1,MET,PAQR3,FGF23,PSMA5,SPTAN1,PPP2R5E,PSMB3,PEBP1,PSMD10,FRS3,SRC,DUSP9,FGF10,RAP1B,MAP2K1,KRAS,UBA52,FGF22,WDR83,RAF1,FGF16,IL2RB,LAMTOR3,CAMK2G,VWF,PSMC1,CUL3,HRAS,KIT,PPP2CB,LAMTOR2,IL5,PSMB2,PSMD1,PSMA6,PEA15,RASGRP3,SHC1,PSMB4,SEM1,DUSP1,PSMC3,PSMA1,IL3,RPS27A,SPRED1,PHB1,PSMD4,PSMD3,JAK2,PSMB7,PSMB1,PSMB5,PSMA3,PSMC4,PSMA4,FGFR1,IL2,PSMC5,PSMB11,PSMB10,PSMA2,PSMB6,DLG4,BRAP,CSK,SPTBN1,PPP5C,ANGPT1,PSME1,PSMD7,FGF17,PSMD14,UBB,PPP2R1A,CSF2,FGF7,JAK1,PSMD12,SHC3,RAP1A,FGF3,PSME2,PSMD6,HBEGF,PSMB9,SPRED2,IL2RA,MAP3K11,NEFL,DUSP10
R-HSA-112412	SOS-mediated signalling	0.00540312728249847	-5.22077736665227	245	96	0.0297305667389285	3229	10285	5709,5695,3717,5689,5693,5684,5704,5685,122706,2260,5705,3558,5699,5694,5683,1742,1445,8315,6711,5536,5720,284,5713,8822,10213,7314,5518,1437,3716,2252,5718,53358,5906,2248,5721,9861,1839,5698,200734,3559,4296,11221,4747,3561,7529,1848,2246,5525,4233,152559,8074,5686,6709,5529,5037,5691,10817,5716,6714,1852,2255,5908,5604,3845,27006,7311,84292,5894,8823,3560,8649,818,7450,8452,5700,28956,5516,3815,3265,3567,5690,5707,8682,5687,6464,25780,5692,7979,1843,5702,5682,6233,3562,5245,5710,161742	PSMD3,PSMB7,JAK2,PSMB1,PSMB5,PSMA3,PSMC4,PSMA4,PSMB11,FGFR1,PSMC5,IL2,PSMB10,PSMB6,PSMA2,DLG4,CSK,BRAP,SPTBN1,PPP5C,PSME1,ANGPT1,PSMD7,FGF17,PSMD14,UBB,PPP2R1A,CSF2,JAK1,FGF7,PSMD12,SHC3,RAP1A,FGF3,PSME2,PSMD6,HBEGF,PSMB9,SPRED2,IL2RA,MAP3K11,DUSP10,NEFL,IL2RG,YWHAB,DUSP6,FGF1,PPP2R5A,MET,PAQR3,FGF23,PSMA5,SPTAN1,PPP2R5E,PEBP1,PSMB3,FRS3,PSMD10,SRC,DUSP9,FGF10,RAP1B,MAP2K1,KRAS,FGF22,UBA52,WDR83,RAF1,FGF16,IL2RB,LAMTOR3,CAMK2G,VWF,CUL3,PSMC1,LAMTOR2,PPP2CB,KIT,HRAS,IL5,PSMB2,PSMD1,PEA15,PSMA6,SHC1,RASGRP3,PSMB4,SEM1,DUSP1,PSMC3,PSMA1,RPS27A,IL3,PHB1,PSMD4,SPRED1
R-HSA-5654687	Downstream signaling of activated FGFR1	0.00565378067298422	-5.175430811941	31	17	0.00526478786001858	3229	10285	5295,2248,6464,10817,2255,2246,8822,23767,2260,8074,5781,3845,3265,2549,23768,5290,27006	PIK3R1,FGF3,SHC1,FRS3,FGF10,FGF1,FGF17,FLRT3,FGFR1,FGF23,PTPN11,KRAS,HRAS,GAB1,FLRT2,PIK3CA,FGF22
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.00565711911642166	-5.17484050637795	87	39	0.0120780427376897	3229	10285	65109,57187,26097,55110,84271,84321,23636,9972,10569,22916,7919,29107,100126351,29894,84248,129401,79023,9775,10212,51362,6426,10762,10189,9785,693221,22794,6427,6432,9877,53981,6429,11097,79228,4116,1977,10898,100302196,57122,9984	UPF3B,THOC2,CHTOP,MAGOHB,POLDIP3,THOC3,NUP62,NUP153,SLU7,NCBP2,DDX39B,NXT1,MIR939,CPSF1,FYTTD1,NUP35,NUP37,EIF4A3,DDX39A,CDC40,SRSF1,NUP50,ALYREF,DHX38,MIR636,CASC3,SRSF2,SRSF7,ZC3H11A,CPSF2,SRSF4,NUP42,THOC6,MAGOH,EIF4E,CPSF4,MIR1234,NUP107,THOC1
R-HSA-6782135	Dual incision in TC-NER	0.00565975282164636	-5.17437505880787	66	31	0.00960049550944565	3229	10285	5984,6917,7314,2966,6233,7311,5433,5441,404672,5436,54107,5435,5111,5983,5431,2033,4331,1022,5985,6119,27339,6118,5425,5438,902,5432,2968,2071,56655,57804,5982	RFC4,TCEA1,UBB,GTF2H2,RPS27A,UBA52,POLR2D,POLR2L,GTF2H5,POLR2G,POLE3,POLR2F,PCNA,RFC3,POLR2B,EP300,MNAT1,CDK7,RFC5,RPA3,PRPF19,RPA2,POLD2,POLR2I,CCNH,POLR2C,GTF2H4,ERCC3,POLE4,POLD4,RFC2
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.00568714822098554	-5.16954634787323	9	7	0.00216785382471353	3229	10285	6233,7311,7314,1499,6714,1500,79872	RPS27A,UBA52,UBB,CTNNB1,SRC,CTNND1,CBLL1
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.00569718007932964	-5.16778394948202	24	14	0.00433570764942707	3229	10285	5425,6118,5558,5984,5111,54107,2237,56655,5983,23649,5982,6119,57804,5985	POLD2,RPA2,PRIM2,RFC4,PCNA,POLE3,FEN1,POLE4,RFC3,POLA2,RFC2,RPA3,POLD4,RFC5
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	0.00584489932985739	-5.14218590749858	11	8	0.00247754722824404	3229	10285	4800,4801,1649,7494,7184,811,3309,468	NFYA,NFYB,DDIT3,XBP1,HSP90B1,CALR,HSPA5,ATF4
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	0.00584489932985739	-5.14218590749858	11	8	0.00247754722824404	3229	10285	2155,632,5627,2159,2158,2147,2677,5045	F7,BGLAP,PROS1,F10,F9,F2,GGCX,FURIN
R-HSA-1059683	Interleukin-6 signaling	0.00584489932985739	-5.14218590749858	11	8	0.00247754722824404	3229	10285	3717,9021,5781,3716,3569,6772,867,3572	JAK2,SOCS3,PTPN11,JAK1,IL6,STAT1,CBL,IL6ST
R-HSA-186797	Signaling by PDGF	0.00602549229030166	-5.11175609500944	376	141	0.0436667698978012	3229	10285	6711,5536,26523,5153,5720,284,4690,5713,8822,941,10213,5781,5567,5578,7314,6776,5518,1385,5709,3717,5695,5295,1399,10768,5689,5684,5693,109,1027,5704,5685,122706,5705,2260,3558,5699,5683,5694,108,1742,940,1445,6696,8315,2248,5721,9861,7059,1839,5698,200734,3559,2931,572,4296,11221,4747,1026,5581,8503,1437,3716,2252,5718,208,53358,5906,6772,10817,5716,6714,1852,4343,2255,118788,5908,5604,3845,27006,7311,84292,5894,57690,3561,5296,29851,4193,5340,7529,1848,2246,5525,4233,152559,8074,5728,5686,6709,5136,5529,8394,5037,5691,6464,25780,5692,7979,1843,5702,7157,942,5682,6233,3562,5710,5245,161742,8823,3560,5045,8649,818,7450,8870,8452,5700,28956,5516,3815,6778,2549,3265,3567,79837,5707,5690,5290,8682,207,10000,5687	SPTBN1,PPP5C,AGO1,PDE1B,PSME1,ANGPT1,NCK1,PSMD7,FGF17,CD80,PSMD14,PTPN11,PRKACB,PRKCA,UBB,STAT5A,PPP2R1A,CREB1,PSMD3,JAK2,PSMB7,PIK3R1,CRKL,AHCYL1,PSMB1,PSMA3,PSMB5,ADCY3,CDKN1B,PSMC4,PSMA4,PSMB11,PSMC5,FGFR1,IL2,PSMB10,PSMA2,PSMB6,ADCY2,DLG4,CD28,CSK,SPP1,BRAP,FGF3,PSME2,PSMD6,THBS3,HBEGF,PSMB9,SPRED2,IL2RA,GSK3A,BAD,MAP3K11,DUSP10,NEFL,CDKN1A,PRKCE,PIK3R3,CSF2,JAK1,FGF7,PSMD12,AKT2,SHC3,RAP1A,STAT1,FRS3,PSMD10,SRC,DUSP9,MOV10,FGF10,PIK3AP1,RAP1B,MAP2K1,KRAS,FGF22,UBA52,WDR83,RAF1,TNRC6C,IL2RG,PIK3R2,ICOS,MDM2,PLG,YWHAB,DUSP6,FGF1,PPP2R5A,MET,PAQR3,FGF23,PTEN,PSMA5,SPTAN1,PDE1A,PPP2R5E,PIP5K1A,PEBP1,PSMB3,SHC1,RASGRP3,PSMB4,SEM1,DUSP1,PSMC3,TP53,CD86,PSMA1,RPS27A,IL3,PSMD4,PHB1,SPRED1,FGF16,IL2RB,FURIN,LAMTOR3,CAMK2G,VWF,IER3,CUL3,PSMC1,LAMTOR2,PPP2CB,KIT,STAT6,GAB1,HRAS,IL5,PIP4K2C,PSMD1,PSMB2,PIK3CA,PEA15,AKT1,AKT3,PSMA6
R-HSA-187687	Signalling to ERKs	0.00602672457948118	-5.1115516033052	263	102	0.0315887271601115	3229	10285	7979,1843,25780,6464,5692,3562,6233,161742,5710,5245,5702,5682,7450,5700,8452,5898,8823,818,8649,3560,5707,5690,8682,5687,3567,3265,3815,28956,5516,2255,5716,10817,1852,6714,84292,7311,27006,6016,5894,5908,5899,3845,5604,7529,5525,2246,1848,3561,5529,6709,5691,5037,152559,4233,5686,8074,3559,200734,5698,5721,2248,1839,9861,4747,11221,4296,2252,3716,5718,7867,1437,53358,5906,8822,5713,5536,6014,6711,284,5720,5518,7314,10213,5693,5684,5704,3717,5695,5709,5689,1399,5694,5683,8315,1445,1742,5685,5699,2260,3558,5705,122706	SEM1,DUSP1,RASGRP3,SHC1,PSMB4,IL3,RPS27A,SPRED1,PSMD4,PHB1,PSMC3,PSMA1,VWF,PSMC1,CUL3,RALA,FGF16,CAMK2G,LAMTOR3,IL2RB,PSMD1,PSMB2,PEA15,PSMA6,IL5,HRAS,KIT,LAMTOR2,PPP2CB,FGF10,PSMD10,FRS3,DUSP9,SRC,WDR83,UBA52,FGF22,RIT1,RAF1,RAP1B,RALB,KRAS,MAP2K1,YWHAB,PPP2R5A,FGF1,DUSP6,IL2RG,PPP2R5E,SPTAN1,PSMB3,PEBP1,PAQR3,MET,PSMA5,FGF23,IL2RA,SPRED2,PSMB9,PSME2,FGF3,HBEGF,PSMD6,NEFL,DUSP10,MAP3K11,FGF7,JAK1,PSMD12,MAPKAPK3,CSF2,SHC3,RAP1A,FGF17,PSMD7,PPP5C,RIT2,SPTBN1,ANGPT1,PSME1,PPP2R1A,UBB,PSMD14,PSMB5,PSMA3,PSMC4,JAK2,PSMB7,PSMD3,PSMB1,CRKL,PSMB6,PSMA2,BRAP,CSK,DLG4,PSMA4,PSMB10,FGFR1,IL2,PSMC5,PSMB11
R-HSA-202131	Metabolism of nitric oxide	0.00661516015371132	-5.01839127101875	22	13	0.00402601424589656	3229	10285	3320,207,51070,2644,857,6697,23564,1785,23576,5805,8976,10434,114757	HSP90AA1,AKT1,NOSIP,GCHFR,CAV1,SPR,DDAH2,DNM2,DDAH1,PTS,WASL,LYPLA1,CYGB
R-HSA-203765	eNOS activation and regulation	0.00661516015371132	-5.01839127101875	22	13	0.00402601424589656	3229	10285	5805,23576,10434,114757,8976,51070,207,3320,1785,23564,6697,857,2644	PTS,DDAH1,LYPLA1,CYGB,WASL,NOSIP,AKT1,HSP90AA1,DNM2,DDAH2,SPR,CAV1,GCHFR
R-HSA-389513	CTLA4 inhibitory signaling	0.00661516015371132	-5.01839127101875	22	13	0.00402601424589656	3229	10285	5529,7525,5518,10000,207,5516,5781,942,208,941,5525,1493,6714	PPP2R5E,YES1,PPP2R1A,AKT3,AKT1,PPP2CB,PTPN11,CD86,AKT2,CD80,PPP2R5A,CTLA4,SRC
R-HSA-5218921	VEGFR2 mediated cell proliferation	0.00662735100738741	-5.01655010102137	258	100	0.0309693403530505	3229	10285	5695,3717,5709,10768,5689,5684,5693,5704,5685,5699,122706,3558,5705,2260,5683,5694,1445,8315,1742,5536,6711,5720,284,8822,5713,10213,5578,5518,7314,1437,5579,3716,2252,5718,53358,5906,5721,2248,1839,9861,3559,200734,5698,4296,11221,4747,3561,7529,2246,5525,1848,152559,4233,5686,8074,5529,6709,5037,5691,10817,5716,1852,6714,2255,5908,3845,5604,84292,27006,7311,5894,8823,8649,818,3560,7450,8452,5700,3567,3815,5516,28956,3265,5707,5690,8682,5687,25780,6464,5692,7979,7422,1843,5702,5682,6233,3562,5710,5245,161742	PSMB7,JAK2,PSMD3,AHCYL1,PSMB1,PSMA3,PSMB5,PSMC4,PSMA4,PSMB10,PSMB11,IL2,PSMC5,FGFR1,PSMA2,PSMB6,CSK,BRAP,DLG4,PPP5C,SPTBN1,PSME1,ANGPT1,FGF17,PSMD7,PSMD14,PRKCA,PPP2R1A,UBB,CSF2,PRKCB,JAK1,FGF7,PSMD12,SHC3,RAP1A,PSME2,FGF3,HBEGF,PSMD6,IL2RA,SPRED2,PSMB9,MAP3K11,DUSP10,NEFL,IL2RG,YWHAB,FGF1,PPP2R5A,DUSP6,PAQR3,MET,PSMA5,FGF23,PPP2R5E,SPTAN1,PEBP1,PSMB3,FRS3,PSMD10,DUSP9,SRC,FGF10,RAP1B,KRAS,MAP2K1,WDR83,FGF22,UBA52,RAF1,FGF16,LAMTOR3,CAMK2G,IL2RB,VWF,CUL3,PSMC1,IL5,KIT,PPP2CB,LAMTOR2,HRAS,PSMD1,PSMB2,PEA15,PSMA6,RASGRP3,SHC1,PSMB4,SEM1,VEGFA,DUSP1,PSMC3,PSMA1,RPS27A,IL3,PSMD4,PHB1,SPRED1
R-HSA-201681	TCF dependent signaling in response to WNT	0.00667140337562657	-5.00992504004241	238	93	0.0288014865283369	3229	10285	5692,7979,11197,4040,8335,1499,5702,857,5682,8334,81847,6233,5710,474382,1856,8452,5700,8323,1387,5516,5707,5690,207,5687,55366,23072,5716,1454,6658,2033,7534,7015,607,7311,22943,56998,5525,5686,5529,5691,8342,5721,6422,9861,5698,80351,8331,1457,255626,8345,6662,3013,94239,3015,8607,4609,50964,5718,3014,7088,55766,208,7514,1452,79577,9101,8322,5720,5713,85236,10213,59349,1487,5518,7314,5695,1460,5709,5689,8350,6657,5693,5684,5704,8348,5685,5699,5705,122706,5694,5683,8970,8658	PSMB4,SEM1,WIF1,LRP6,H2AC4,CTNNB1,PSMC3,CAV1,PSMA1,H2AC6,RNF146,RPS27A,PSMD4,H2AB1,DVL2,CUL3,PSMC1,FZD6,CREBBP,PPP2CB,PSMD1,PSMB2,AKT1,PSMA6,LGR4,HECW1,PSMD10,CSNK1E,SOX3,EP300,YWHAZ,TERT,BCL9,UBA52,DKK1,CTNNBIP1,PPP2R5A,PSMA5,PPP2R5E,PSMB3,H2BC14,PSME2,SFRP1,PSMD6,PSMB9,TNKS2,H2AC14,CSNK2A1,H2BC1,H2BC9,SOX9,H2AC7,H2AZ2,H2AZ1,RUVBL1,MYC,SOST,PSMD12,H2AX,TLE1,H2AJ,AKT2,XPO1,CSNK1A1,CDC73,USP8,FZD4,PSME1,PSMD7,H2BC12,PSMD14,KLHL12,CTBP1,PPP2R1A,UBB,PSMB7,CSNK2B,PSMD3,PSMB1,H3C1,SOX2,PSMB5,PSMA3,PSMC4,H2BC17,PSMA4,PSMB10,PSMC5,PSMB11,PSMB6,PSMA2,H2BC11,TNKS
R-HSA-170968	Frs2-mediated activation	0.00716754936113838	-4.93819147343055	250	97	0.030040260142459	3229	10285	2252,3716,5718,1437,53358,5906,5698,200734,3559,2248,5721,9861,1839,4747,11221,4296,5693,5684,5704,5709,5695,3717,1399,5689,5694,5683,1742,8315,1445,5685,2260,3558,5705,122706,5699,5713,8822,6711,5536,284,5720,7314,5518,10213,7450,8452,5700,8823,3560,8649,818,5690,5707,8682,5687,3265,5516,28956,3815,3567,7979,1843,6464,25780,5692,3562,6233,161742,5245,5710,5702,5682,7529,1848,5525,2246,3561,6709,5529,5691,5037,4233,152559,8074,5686,2255,5716,10817,6714,1852,7311,27006,84292,5894,5908,5604,3845	FGF7,JAK1,PSMD12,CSF2,SHC3,RAP1A,PSMB9,SPRED2,IL2RA,FGF3,PSME2,PSMD6,HBEGF,NEFL,DUSP10,MAP3K11,PSMB5,PSMA3,PSMC4,PSMD3,PSMB7,JAK2,CRKL,PSMB1,PSMB6,PSMA2,DLG4,BRAP,CSK,PSMA4,FGFR1,IL2,PSMC5,PSMB11,PSMB10,PSMD7,FGF17,SPTBN1,PPP5C,ANGPT1,PSME1,UBB,PPP2R1A,PSMD14,VWF,CUL3,PSMC1,FGF16,IL2RB,LAMTOR3,CAMK2G,PSMB2,PSMD1,PEA15,PSMA6,HRAS,PPP2CB,LAMTOR2,KIT,IL5,SEM1,DUSP1,SHC1,RASGRP3,PSMB4,IL3,RPS27A,SPRED1,PHB1,PSMD4,PSMC3,PSMA1,YWHAB,DUSP6,PPP2R5A,FGF1,IL2RG,SPTAN1,PPP2R5E,PSMB3,PEBP1,MET,PAQR3,FGF23,PSMA5,FGF10,PSMD10,FRS3,SRC,DUSP9,UBA52,FGF22,WDR83,RAF1,RAP1B,MAP2K1,KRAS
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.00724083468992215	-4.92801879056646	34	18	0.00557448126354909	3229	10285	867,9040,7048,7514,5500,7314,6233,2280,7311,5501,4088,4087,57154,4738,4089,5045,10273,9958	CBL,UBE2M,TGFBR2,XPO1,PPP1CB,UBB,RPS27A,FKBP1A,UBA52,PPP1CC,SMAD3,SMAD2,SMURF1,NEDD8,SMAD4,FURIN,STUB1,USP15
R-HSA-167044	Signalling to RAS	0.00740763860708549	-4.90524356696897	256	99	0.03065964694952	3229	10285	5898,8452,5700,7450,3560,8649,818,8823,5687,8682,5690,5707,3265,5516,3815,28956,3567,1843,7979,5692,6464,25780,161742,5245,5710,3562,6233,5682,5702,1848,5525,2246,7529,3561,5691,5037,6709,5529,8074,5686,4233,152559,2255,6714,1852,5716,10817,5894,7311,27006,84292,5604,3845,5908,5899,5718,2252,3716,7867,1437,5906,53358,5698,200734,3559,9861,1839,2248,5721,4747,11221,4296,5704,5684,5693,5689,5709,3717,5695,1742,8315,1445,5694,5683,2260,5705,3558,122706,5699,5685,5713,8822,284,5720,6711,5536,7314,5518,10213	RALA,CUL3,PSMC1,VWF,IL2RB,LAMTOR3,CAMK2G,FGF16,PSMA6,PEA15,PSMB2,PSMD1,HRAS,PPP2CB,KIT,LAMTOR2,IL5,DUSP1,SEM1,PSMB4,SHC1,RASGRP3,SPRED1,PHB1,PSMD4,IL3,RPS27A,PSMA1,PSMC3,DUSP6,PPP2R5A,FGF1,YWHAB,IL2RG,PSMB3,PEBP1,SPTAN1,PPP2R5E,FGF23,PSMA5,MET,PAQR3,FGF10,SRC,DUSP9,PSMD10,FRS3,RAF1,UBA52,FGF22,WDR83,MAP2K1,KRAS,RAP1B,RALB,PSMD12,FGF7,JAK1,MAPKAPK3,CSF2,RAP1A,SHC3,PSMB9,SPRED2,IL2RA,PSMD6,HBEGF,FGF3,PSME2,NEFL,DUSP10,MAP3K11,PSMC4,PSMA3,PSMB5,PSMB1,PSMD3,JAK2,PSMB7,DLG4,BRAP,CSK,PSMB6,PSMA2,FGFR1,PSMC5,IL2,PSMB11,PSMB10,PSMA4,PSMD7,FGF17,ANGPT1,PSME1,SPTBN1,PPP5C,UBB,PPP2R1A,PSMD14
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.00765463736989761	-4.87244362266045	20	12	0.00371632084236606	3229	10285	29945,119504,29882,991,25906,8697,8881,7321,4085,51529,246184,9184	ANAPC4,ANAPC16,ANAPC2,CDC20,ANAPC15,CDC23,CDC16,UBE2D1,MAD2L1,ANAPC11,CDC26,BUB3
R-HSA-69186	Lagging Strand Synthesis	0.00765463736989761	-4.87244362266045	20	12	0.00371632084236606	3229	10285	5111,2237,6118,5558,5984,5425,5985,57804,5982,6119,23649,5983	PCNA,FEN1,RPA2,PRIM2,RFC4,POLD2,RFC5,POLD4,RFC2,RPA3,POLA2,RFC3
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.00765463736989761	-4.87244362266045	20	12	0.00371632084236606	3229	10285	7321,8881,8697,25906,991,29882,9184,119504,246184,51529,4085,29945	UBE2D1,CDC16,CDC23,ANAPC15,CDC20,ANAPC2,BUB3,ANAPC16,CDC26,ANAPC11,MAD2L1,ANAPC4
R-HSA-2980736	Peptide hormone metabolism	0.00766766279652174	-4.87074343018017	91	40	0.0123877361412202	3229	10285	2784,28972,9314,10640,60559,2688,6804,94115,1509,5972,7349,64924,148867,9789,6844,51764,4311,2028,3952,3623,1363,3972,1215,10159,11336,57393,30001,5873,23478,149371,43,5080,5126,55770,1499,51738,3479,1803,55763,407012	GNB3,SPCS1,KLF4,EXOC5,SPCS3,GH1,STX1A,CGB8,CTSD,REN,UCN,SLC30A5,SLC30A7,SPCS2,VAMP2,GNG13,MME,ENPEP,LEP,INHA,CPE,LHB,CMA1,ATP6AP2,EXOC3,CLTRN,ERO1A,RAB27A,SEC11A,EXOC8,ACHE,PAX6,PCSK2,EXOC2,CTNNB1,GHRL,IGF1,DPP4,EXOC1,MIR24-1
R-HSA-901042	Calnexin/calreticulin cycle	0.00785022656783249	-4.84721288546006	27	15	0.00464540105295757	3229	10285	84447,80267,7314,55741,7311,6233,23193,7844,6048,51009,2923,811,10956,11236,9695	SYVN1,EDEM3,UBB,EDEM2,UBA52,RPS27A,GANAB,RNF103,RNF5,DERL2,PDIA3,CALR,OS9,RNF139,EDEM1
R-HSA-177929	Signaling by EGFR	0.0079494319065585	-4.83465481116369	364	136	0.0421183028801487	3229	10285	29851,3561,5296,1848,2246,5525,4193,7529,998,8074,5728,5686,4233,152559,5037,5691,6709,5136,5529,8394,6714,1852,10817,5716,118788,2255,4343,5604,3845,5908,57690,5894,27006,7311,84292,3560,8649,818,8823,8870,8452,5700,7450,79837,28956,5516,3815,3265,2549,3567,5290,10000,8682,5687,207,5707,5690,5692,25780,6464,1843,7979,942,5682,5702,7157,5710,5245,161742,6233,3562,5295,10768,5689,5709,1385,3717,5695,1027,5704,5684,5693,109,122706,3558,5705,2260,5699,5685,1742,940,1445,8315,5683,5694,108,5153,5720,284,6711,26523,5536,5713,8822,941,5781,10213,7314,867,5518,5567,5578,1026,5581,8503,1437,5718,3716,2252,208,5906,10252,53358,9861,1839,2248,5721,9146,5698,200734,3559,2931,572,4296,11221,4747	ICOS,IL2RG,PIK3R2,DUSP6,FGF1,PPP2R5A,MDM2,YWHAB,CDC42,FGF23,PTEN,PSMA5,MET,PAQR3,PEBP1,PSMB3,SPTAN1,PDE1A,PPP2R5E,PIP5K1A,SRC,DUSP9,FRS3,PSMD10,PIK3AP1,FGF10,MOV10,MAP2K1,KRAS,RAP1B,TNRC6C,RAF1,FGF22,UBA52,WDR83,IL2RB,LAMTOR3,CAMK2G,FGF16,IER3,CUL3,PSMC1,VWF,PIP4K2C,LAMTOR2,PPP2CB,KIT,HRAS,GAB1,IL5,PIK3CA,AKT3,PEA15,PSMA6,AKT1,PSMD1,PSMB2,PSMB4,RASGRP3,SHC1,DUSP1,SEM1,CD86,PSMA1,PSMC3,TP53,PSMD4,PHB1,SPRED1,RPS27A,IL3,PIK3R1,AHCYL1,PSMB1,PSMD3,CREB1,JAK2,PSMB7,CDKN1B,PSMC4,PSMA3,PSMB5,ADCY3,PSMB11,IL2,PSMC5,FGFR1,PSMB10,PSMA4,DLG4,CD28,CSK,BRAP,PSMA2,PSMB6,ADCY2,PDE1B,PSME1,ANGPT1,SPTBN1,AGO1,PPP5C,PSMD7,FGF17,CD80,PTPN11,PSMD14,UBB,CBL,PPP2R1A,PRKACB,PRKCA,CDKN1A,PRKCE,PIK3R3,CSF2,PSMD12,JAK1,FGF7,AKT2,RAP1A,SPRY1,SHC3,PSMD6,HBEGF,FGF3,PSME2,HGS,PSMB9,SPRED2,IL2RA,GSK3A,BAD,MAP3K11,DUSP10,NEFL
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	0.00857844361541144	-4.75850277874185	32	17	0.00526478786001858	3229	10285	54331,55970,2793,2784,6714,2767,2785,51764,2782,59345,9630,2788,2790,2791,2776,2787,2147	GNG2,GNG12,GNGT2,GNB3,SRC,GNA11,GNG3,GNG13,GNB1,GNB4,GNA14,GNG7,GNG10,GNG11,GNAQ,GNG5,F2
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.00892325545632004	-4.7190944375016	37	19	0.00588417466707959	3229	10285	5983,56655,5985,57804,23583,5982,6119,6118,4350,10038,5984,5425,3980,5423,4968,5111,328,2237,54107	RFC3,POLE4,RFC5,POLD4,SMUG1,RFC2,RPA3,RPA2,MPG,PARP2,RFC4,POLD2,LIG3,POLB,OGG1,PCNA,APEX1,FEN1,POLE3
R-HSA-73884	Base Excision Repair	0.00892325545632004	-4.7190944375016	37	19	0.00588417466707959	3229	10285	2237,54107,328,5111,4968,5423,3980,5425,5984,10038,4350,6118,6119,5982,23583,57804,5985,56655,5983	FEN1,POLE3,APEX1,PCNA,OGG1,POLB,LIG3,POLD2,RFC4,PARP2,MPG,RPA2,RPA3,RFC2,SMUG1,POLD4,RFC5,POLE4,RFC3
R-HSA-170984	ARMS-mediated activation	0.00909733873092215	-4.69977335538175	249	96	0.0297305667389285	3229	10285	4296,4747,11221,2248,5721,9861,1839,5698,3559,200734,53358,5906,1437,2252,3716,5718,10213,7314,5518,6711,5536,284,5720,5713,8822,5685,3558,2260,5705,122706,5699,5683,5694,1742,8315,1445,5709,3717,5695,5689,5684,5693,5704,5702,5682,3562,6233,161742,5710,5245,6464,25780,5692,7979,1843,3265,3815,28956,5516,3567,5690,5707,8682,5687,8823,3560,8649,818,7450,8452,5700,5908,5604,3845,7311,27006,84292,5894,5716,10817,6714,1852,2255,4233,152559,8074,5686,6709,5529,5691,5037,3561,7529,1848,5525,2246	MAP3K11,NEFL,DUSP10,FGF3,PSME2,PSMD6,HBEGF,PSMB9,IL2RA,SPRED2,SHC3,RAP1A,CSF2,FGF7,JAK1,PSMD12,PSMD14,UBB,PPP2R1A,SPTBN1,PPP5C,ANGPT1,PSME1,PSMD7,FGF17,PSMA4,IL2,FGFR1,PSMC5,PSMB11,PSMB10,PSMA2,PSMB6,DLG4,BRAP,CSK,PSMD3,JAK2,PSMB7,PSMB1,PSMA3,PSMB5,PSMC4,PSMC3,PSMA1,IL3,RPS27A,SPRED1,PSMD4,PHB1,SHC1,RASGRP3,PSMB4,SEM1,DUSP1,HRAS,KIT,LAMTOR2,PPP2CB,IL5,PSMB2,PSMD1,PEA15,PSMA6,FGF16,IL2RB,LAMTOR3,CAMK2G,VWF,CUL3,PSMC1,RAP1B,MAP2K1,KRAS,UBA52,FGF22,WDR83,RAF1,PSMD10,FRS3,SRC,DUSP9,FGF10,MET,PAQR3,FGF23,PSMA5,SPTAN1,PPP2R5E,PSMB3,PEBP1,IL2RG,YWHAB,DUSP6,PPP2R5A,FGF1
R-HSA-169893	Prolonged ERK activation events	0.00923509404223116	-4.68474448214173	252	97	0.030040260142459	3229	10285	161742,5245,5710,3562,6233,5682,5702,1843,7979,5692,6464,25780,8682,5687,5707,5690,3567,3265,3815,5516,28956,8452,5700,7450,8649,818,3560,8823,5894,84292,7311,27006,3845,5604,5908,2255,1852,6714,5716,10817,5691,5037,5529,6709,5686,8074,152559,4233,5525,2246,1848,7529,3561,4747,11221,4296,200734,3559,5698,1839,9861,5721,2248,5906,53358,5718,2252,3716,1437,5518,7314,10213,8822,5713,284,5720,5536,6711,8315,1445,1742,5694,5683,5699,5705,2260,3558,122706,5685,5704,5684,5693,5689,1399,3717,5695,5709	SPRED1,PHB1,PSMD4,IL3,RPS27A,PSMA1,PSMC3,DUSP1,SEM1,PSMB4,SHC1,RASGRP3,PEA15,PSMA6,PSMD1,PSMB2,IL5,HRAS,KIT,PPP2CB,LAMTOR2,CUL3,PSMC1,VWF,LAMTOR3,CAMK2G,IL2RB,FGF16,RAF1,WDR83,UBA52,FGF22,KRAS,MAP2K1,RAP1B,FGF10,DUSP9,SRC,PSMD10,FRS3,PSMB3,PEBP1,PPP2R5E,SPTAN1,PSMA5,FGF23,PAQR3,MET,PPP2R5A,FGF1,DUSP6,YWHAB,IL2RG,NEFL,DUSP10,MAP3K11,SPRED2,IL2RA,PSMB9,HBEGF,PSMD6,PSME2,FGF3,RAP1A,SHC3,PSMD12,FGF7,JAK1,CSF2,PPP2R1A,UBB,PSMD14,FGF17,PSMD7,ANGPT1,PSME1,PPP5C,SPTBN1,BRAP,CSK,DLG4,PSMB6,PSMA2,PSMB10,PSMC5,FGFR1,IL2,PSMB11,PSMA4,PSMC4,PSMA3,PSMB5,PSMB1,CRKL,JAK2,PSMB7,PSMD3
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.00924771424401256	-4.6833788667496	25	14	0.00433570764942707	3229	10285	54487,5901,26523,5431,23405,5432,5436,57510,5435,8575,5438,5441,5433,29102	DGCR8,RAN,AGO1,POLR2B,DICER1,POLR2C,POLR2G,XPO5,POLR2F,PRKRA,POLR2I,POLR2L,POLR2D,DROSHA
R-HSA-5673000	RAF activation	0.00924771424401256	-4.6833788667496	25	14	0.00433570764942707	3229	10285	3717,6714,7529,5525,3265,5516,4296,5604,3845,5529,5245,5894,8315,5518	JAK2,SRC,YWHAB,PPP2R5A,HRAS,PPP2CB,MAP3K11,MAP2K1,KRAS,PPP2R5E,PHB1,RAF1,BRAP,PPP2R1A
R-HSA-933542	TRAF6 mediated NF-kB activation	0.00924771424401256	-4.6833788667496	25	14	0.00433570764942707	3229	10285	23586,6285,4615,4792,3551,4793,3146,64135,7189,1660,57506,4790,7186,177	RIGI,S100B,MYD88,NFKBIA,IKBKB,NFKBIB,HMGB1,IFIH1,TRAF6,DHX9,MAVS,NFKB1,TRAF2,AGER
R-HSA-5603037	IRAK4 deficiency (TLR5)	0.00970288982802425	-4.6353315174274	4	4	0.00123877361412202	3229	10285	81793,51135,7100,4615	TLR10,IRAK4,TLR5,MYD88
R-HSA-112313	Neurotransmitter uptake and Metabolism In Glial Cells	0.00970288982802425	-4.6353315174274	4	4	0.00123877361412202	3229	10285	2752,81539,6506,6507	GLUL,SLC38A1,SLC1A2,SLC1A3
R-HSA-173107	Binding and entry of HIV virion	0.00970288982802425	-4.6353315174274	4	4	0.00123877361412202	3229	10285	7852,5478,920,1234	CXCR4,PPIA,CD4,CCR5
R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	0.00970288982802425	-4.6353315174274	4	4	0.00123877361412202	3229	10285	2752,81539,6507,6506	GLUL,SLC38A1,SLC1A3,SLC1A2
R-HSA-162599	Late Phase of HIV Life Cycle	0.0100529815186879	-4.59988601994829	139	57	0.0176525240012388	3229	10285	6880,27243,6233,404672,129401,2960,9525,92421,6829,22916,25978,9972,23636,5432,7251,27183,2968,51534,7514,57122,2962,11097,5438,51160,5901,5045,79023,1025,2071,6749,2959,6882,6921,5436,6827,2958,2963,5435,6879,6881,6917,7314,5902,2966,5433,7311,5441,1022,2961,6873,5478,5431,4331,902,2957,51510,10762	TAF9,CHMP2A,RPS27A,GTF2H5,NUP35,GTF2E1,VPS4B,CHMP4C,SUPT5H,NCBP2,CHMP2B,NUP153,NUP62,POLR2C,TSG101,VPS4A,GTF2H4,VTA1,XPO1,NUP107,GTF2F1,NUP42,POLR2I,VPS28,RAN,FURIN,NUP37,CDK9,ERCC3,SSRP1,GTF2B,TAF11,ELOC,POLR2G,SUPT4H1,GTF2A2,GTF2F2,POLR2F,TAF7,TAF10,TCEA1,UBB,RANBP1,GTF2H2,POLR2D,UBA52,POLR2L,CDK7,GTF2E2,TAF2,PPIA,POLR2B,MNAT1,CCNH,GTF2A1,CHMP5,NUP50
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.0100821267860756	-4.59699104791222	16	10	0.00309693403530505	3229	10285	7290,3009,4001,3024,25842,29855,3007,3159,7157,5925	HIRA,H1-5,LMNB1,H1-1,ASF1A,UBN1,H1-3,HMGA1,TP53,RB1
R-HSA-918233	TRAF3-dependent IRF activation pathway	0.0100821267860756	-4.59699104791222	16	10	0.00309693403530505	3229	10285	64135,3665,1387,2033,3456,29110,57506,80143,3661,23586	IFIH1,IRF7,CREBBP,EP300,IFNB1,TBK1,MAVS,SIKE1,IRF3,RIGI
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	0.010170134670304	-4.58829982709154	30	16	0.00495509445648808	3229	10285	7328,27338,7319,55284,7327,7332,3093,7314,6233,7311,10477,7320,8078,7321,90268,7347	UBE2H,UBE2S,UBE2A,UBE2W,UBE2G2,UBE2L3,UBE2K,UBB,RPS27A,UBA52,UBE2E3,UBE2B,USP5,UBE2D1,OTULIN,UCHL3
R-HSA-5654696	Downstream signaling of activated FGFR2	0.010170134670304	-4.58829982709154	30	16	0.00495509445648808	3229	10285	2255,8822,2246,2252,5295,2248,8823,6464,10817,5290,27006,8074,5781,3845,2549,3265	FGF10,FGF17,FGF1,FGF7,PIK3R1,FGF3,FGF16,SHC1,FRS3,PIK3CA,FGF22,FGF23,PTPN11,KRAS,GAB1,HRAS
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.010170134670304	-4.58829982709154	30	16	0.00495509445648808	3229	10285	5425,6233,7311,5984,7314,6118,54107,5111,56655,5983,6119,5982,7320,57804,5985,51514	POLD2,RPS27A,UBA52,RFC4,UBB,RPA2,POLE3,PCNA,POLE4,RFC3,RPA3,RFC2,UBE2B,POLD4,RFC5,DTL
R-HSA-8854214	TBC/RABGAPs	0.0105053428199956	-4.55587131123425	45	22	0.00681325487767111	3229	10285	11337,51560,382,79735,11345,11021,5867,5878,9230,5870,83452,125058,8766,374403,4943,51762,57465,5868,10133,9363,54662,81631	GABARAP,RAB6B,ARF6,TBC1D17,GABARAPL2,RAB35,RAB4A,RAB5C,RAB11B,RAB6A,RAB33B,TBC1D16,RAB11A,TBC1D10C,TBC1D25,RAB8B,TBC1D24,RAB5A,OPTN,RAB33A,TBC1D13,MAP1LC3B
R-HSA-5675221	Negative regulation of MAPK pathway	0.0106715302997307	-4.54017580317149	40	20	0.0061938680706101	3229	10285	5536,1852,7529,5525,1848,1843,152559,5516,3265,3845,5604,6233,5529,7311,11221,5518,8315,5037,5894,7314	PPP5C,DUSP9,YWHAB,PPP2R5A,DUSP6,DUSP1,PAQR3,PPP2CB,HRAS,KRAS,MAP2K1,RPS27A,PPP2R5E,UBA52,DUSP10,PPP2R1A,BRAP,PEBP1,RAF1,UBB
R-HSA-69091	Polymerase switching	0.0114150715256339	-4.47282073308625	14	9	0.00278724063177454	3229	10285	5425,5983,23649,5984,5558,5111,5982,5985,57804	POLD2,RFC3,POLA2,RFC4,PRIM2,PCNA,RFC2,RFC5,POLD4
R-HSA-69109	Leading Strand Synthesis	0.0114150715256339	-4.47282073308625	14	9	0.00278724063177454	3229	10285	57804,5985,5982,5111,5558,5983,23649,5984,5425	POLD4,RFC5,RFC2,PCNA,PRIM2,RFC3,POLA2,RFC4,POLD2
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.0114150715256339	-4.47282073308625	14	9	0.00278724063177454	3229	10285	5425,5983,23649,5984,5558,5982,5111,57804,5985	POLD2,RFC3,POLA2,RFC4,PRIM2,RFC2,PCNA,POLD4,RFC5
R-HSA-162594	Early Phase of HIV Life Cycle	0.0114150715256339	-4.47282073308625	14	9	0.00278724063177454	3229	10285	7520,920,3836,3159,8815,2237,7852,5478,1234	XRCC5,CD4,KPNA1,HMGA1,BANF1,FEN1,CXCR4,PPIA,CCR5
R-HSA-166520	Signalling by NGF	0.0114264451115988	-4.47182486340863	477	173	0.0535769588107773	3229	10285	5898,5700,8452,5045,8649,5290,207,8682,5707,5690,5516,3265,8841,3551,27018,6464,25780,5710,5245,3562,5682,1848,2246,5296,3561,2002,51107,6709,8394,5728,4790,4233,152559,4343,57142,5716,57690,5894,27006,5604,3845,5718,3716,5581,1437,53358,208,5698,3559,7189,2248,2931,4296,572,5704,7410,1399,10768,4974,5689,3717,4915,5683,5694,108,122706,2260,5685,5153,5720,284,6711,7314,221472,5518,5781,10213,4208,55851,8870,7450,3560,818,6655,8823,6610,10000,5687,79837,3815,28956,2549,3567,1843,7979,1845,5692,161742,6233,942,5702,7157,5525,4193,7529,29851,5037,5691,5136,160,5529,8074,5686,26574,7074,2255,118788,4792,6714,1852,10817,6016,7311,84292,5899,5908,2252,1026,8503,7867,466,5906,1173,4205,84904,1175,4615,200734,9861,1839,5721,8878,10126,11221,4747,9459,1027,5693,5684,109,5295,5709,1385,5695,1742,940,1445,8315,5705,3558,5699,11108,1785,5713,941,8822,23385,5664,6014,5536,26523,5567,5578	RALA,PSMC1,CUL3,FURIN,LAMTOR3,PIK3CA,AKT1,PEA15,PSMD1,PSMB2,PPP2CB,HRAS,HDAC3,IKBKB,BEX3,SHC1,RASGRP3,PSMD4,PHB1,IL3,PSMA1,DUSP6,FGF1,PIK3R2,IL2RG,ELK1,APH1A,SPTAN1,PIP5K1A,PTEN,NFKB1,MET,PAQR3,MOV10,RTN4,PSMD10,TNRC6C,RAF1,FGF22,MAP2K1,KRAS,PSMD12,JAK1,PRKCE,CSF2,SHC3,AKT2,PSMB9,IL2RA,TRAF6,FGF3,GSK3A,MAP3K11,BAD,PSMC4,VAV2,CRKL,AHCYL1,OMG,PSMB1,JAK2,NTRK2,PSMA2,PSMB6,ADCY2,PSMB11,FGFR1,PSMA4,PDE1B,PSME1,ANGPT1,SPTBN1,UBB,FGD2,PPP2R1A,PTPN11,PSMD14,MEF2C,PSENEN,IER3,VWF,IL2RB,CAMK2G,SOS2,FGF16,SMPD2,AKT3,PSMA6,PIP4K2C,KIT,LAMTOR2,GAB1,IL5,DUSP1,SEM1,DUSP3,PSMB4,SPRED1,RPS27A,CD86,PSMC3,TP53,PPP2R5A,MDM2,YWHAB,ICOS,PEBP1,PSMB3,PDE1A,AP2A1,PPP2R5E,FGF23,PSMA5,AATF,TIAM1,FGF10,PIK3AP1,NFKBIA,SRC,DUSP9,FRS3,RIT1,UBA52,WDR83,RALB,RAP1B,FGF7,CDKN1A,PIK3R3,MAPKAPK3,ATF1,RAP1A,AP2M1,MEF2A,ARHGEF39,AP2S1,MYD88,SPRED2,PSMD6,HBEGF,PSME2,SQSTM1,DNAL4,DUSP10,NEFL,ARHGEF6,CDKN1B,PSMB5,PSMA3,ADCY3,PIK3R1,PSMD3,CREB1,PSMB7,DLG4,CD28,CSK,BRAP,PSMC5,IL2,PSMB10,PRDM4,DNM2,PSMD7,CD80,FGF17,NCSTN,PSEN2,RIT2,PPP5C,AGO1,PRKACB,PRKCA
R-HSA-418597	G alpha (z) signalling events	0.0120481525221901	-4.4188439484604	48	23	0.00712294828120161	3229	10285	54331,2771,55970,109,5579,2784,5581,2793,2781,406974,10287,2773,2785,51764,5578,108,2782,2790,2788,59345,5588,2791,2787	GNG2,GNAI2,GNG12,ADCY3,PRKCB,GNB3,PRKCE,GNGT2,GNAZ,MIR197,RGS19,GNAI3,GNG3,GNG13,PRKCA,ADCY2,GNB1,GNG10,GNG7,GNB4,PRKCQ,GNG11,GNG5
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	0.0120660694728533	-4.41735794124326	28	15	0.00464540105295757	3229	10285	11258,5049,8655,5050,2589,23299,51164,10671,2590,5870,51560,1780,5048,1781,22931	DCTN3,PAFAH1B2,DYNLL1,PAFAH1B3,GALNT1,BICD2,DCTN4,DCTN6,GALNT2,RAB6A,RAB6B,DYNC1I1,PAFAH1B1,DYNC1I2,RAB18
R-HSA-2022854	Keratan sulfate biosynthesis	0.0120660694728533	-4.41735794124326	28	15	0.00464540105295757	3229	10285	8702,9331,6483,9435,6482,8534,8703,11041,10678,4060,6484,2331,4969,2683,5549	B4GALT4,B4GALT6,ST3GAL2,CHST2,ST3GAL1,CHST1,B4GALT3,B4GAT1,B3GNT2,LUM,ST3GAL4,FMOD,OGN,B4GALT1,PRELP
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	0.0120660694728533	-4.41735794124326	28	15	0.00464540105295757	3229	10285	2787,2791,2790,2788,783,59345,2782,51764,2785,784,2793,2784,2771,55970,54331	GNG5,GNG11,GNG10,GNG7,CACNB2,GNB4,GNB1,GNG13,GNG3,CACNB3,GNGT2,GNB3,GNAI2,GNG12,GNG2
R-HSA-388841	Costimulation by the CD28 family	0.012296153560745	-4.39846878414905	69	31	0.00960049550944565	3229	10285	5062,6714,941,1493,8764,9402,5781,942,29126,80380,5518,9020,5296,920,917,5295,29851,8503,998,5525,5516,5133,208,5529,7525,5290,1445,919,10000,207,940	PAK2,SRC,CD80,CTLA4,TNFRSF14,GRAP2,PTPN11,CD86,CD274,PDCD1LG2,PPP2R1A,MAP3K14,PIK3R2,CD4,CD3G,PIK3R1,ICOS,PIK3R3,CDC42,PPP2R5A,PPP2CB,PDCD1,AKT2,PPP2R5E,YES1,PIK3CA,CSK,CD247,AKT3,AKT1,CD28
R-HSA-1638074	Keratan sulfate/keratin metabolism	0.0125953268261154	-4.37442942063647	33	17	0.00526478786001858	3229	10285	4060,11041,10678,2683,4969,2331,6484,5549,3073,9331,8702,6483,6482,9435,8703,8534,3074	LUM,B4GAT1,B3GNT2,B4GALT1,OGN,FMOD,ST3GAL4,PRELP,HEXA,B4GALT6,B4GALT4,ST3GAL2,ST3GAL1,CHST2,B4GALT3,CHST1,HEXB
R-HSA-3371511	HSF1 activation	0.0127233521995674	-4.36431621808828	12	8	0.00247754722824404	3229	10285	10728,3281,6119,1915,3326,3320,6118,10013	PTGES3,HSBP1,RPA3,EEF1A1,HSP90AB1,HSP90AA1,RPA2,HDAC6
R-HSA-69618	Mitotic Spindle Checkpoint	0.0128131985434591	-4.3572795031046	21	12	0.00371632084236606	3229	10285	29882,991,25906,8697,8881,7321,29945,4085,51529,246184,9184,119504	ANAPC2,CDC20,ANAPC15,CDC23,CDC16,UBE2D1,ANAPC4,MAD2L1,ANAPC11,CDC26,BUB3,ANAPC16
R-HSA-422356	Regulation of insulin secretion	0.0131595355454513	-4.33060864660661	80	35	0.0108392691235677	3229	10285	784,6616,6513,10768,6812,2793,2784,2771,292,6804,2787,291,2791,23236,2776,783,9630,2790,23568,51764,5330,2785,6844,5906,3767,55970,3745,54331,59345,2788,5578,2782,5567,1131,2767	CACNB3,SNAP25,SLC2A1,AHCYL1,STXBP1,GNGT2,GNB3,GNAI2,SLC25A5,STX1A,GNG5,SLC25A4,GNG11,PLCB1,GNAQ,CACNB2,GNA14,GNG10,ARL2BP,GNG13,PLCB2,GNG3,VAMP2,RAP1A,KCNJ11,GNG12,KCNB1,GNG2,GNB4,GNG7,PRKCA,GNB1,PRKACB,CHRM3,GNA11
R-HSA-190370	FGFR1b ligand binding and activation	0.0134891958651847	-4.30586622023641	6	5	0.00154846701765252	3229	10285	2260,2255,2246,2248,27006	FGFR1,FGF10,FGF1,FGF3,FGF22
R-HSA-112310	Neurotransmitter Release Cycle	0.0136052347867051	-4.29730064951214	51	24	0.00743264168473212	3229	10285	6812,8541,6616,5864,6529,2572,6804,54407,6538,6844,80331,8499,6539,55327,10550,140679,6507,8224,8573,10815,64130,6505,6506,3312	STXBP1,PPFIA3,SNAP25,RAB3A,SLC6A1,GAD2,STX1A,SLC38A2,SLC6A11,VAMP2,DNAJC5,PPFIA2,SLC6A12,LIN7C,ARL6IP5,SLC32A1,SLC1A3,SYN3,CASK,CPLX1,LIN7B,SLC1A1,SLC1A2,HSPA8
R-HSA-110056	MAPK3 (ERK1) activation	0.0138206597025281	-4.28159072643255	10	7	0.00216785382471353	3229	10285	3572,3716,3569,5604,983,5781,3717	IL6ST,JAK1,IL6,MAP2K1,CDK1,PTPN11,JAK2
R-HSA-399997	Acetylcholine regulates insulin secretion	0.0138206597025281	-4.28159072643255	10	7	0.00216785382471353	3229	10285	9630,2776,23236,5330,2767,1131,5578	GNA14,GNAQ,PLCB1,PLCB2,GNA11,CHRM3,PRKCA
R-HSA-159740	Gamma-carboxylation of protein precursors	0.0138206597025281	-4.28159072643255	10	7	0.00216785382471353	3229	10285	5627,632,2155,2159,2677,2147,2158	PROS1,BGLAP,F7,F10,GGCX,F2,F9
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	0.0138206597025281	-4.28159072643255	10	7	0.00216785382471353	3229	10285	5045,2159,2158,5627,632,2147,2155	FURIN,F10,F9,PROS1,BGLAP,F2,F7
R-HSA-190377	FGFR2b ligand binding and activation	0.0138206597025281	-4.28159072643255	10	7	0.00216785382471353	3229	10285	2246,2255,27006,2252,83888,2248,9982	FGF1,FGF10,FGF22,FGF7,FGFBP2,FGF3,FGFBP1
R-HSA-111367	SLBP independent Processing of Histone Pre-mRNAs	0.0138206597025281	-4.28159072643255	10	7	0.00216785382471353	3229	10285	6635,6628,25888,84967,6637,6634,22916	SNRPE,SNRPB,ZNF473,LSM10,SNRPG,SNRPD3,NCBP2
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.0143236013297584	-4.24584665955956	75	33	0.0102198823165067	3229	10285	22916,29107,7919,23636,84321,84271,10569,9972,26097,57187,55110,65109,129401,84248,6432,6427,9785,22794,693221,51362,10189,6426,10762,10212,79023,9775,9984,57122,4116,79228,11097,6429,9877	NCBP2,NXT1,DDX39B,NUP62,THOC3,POLDIP3,SLU7,NUP153,CHTOP,THOC2,MAGOHB,UPF3B,NUP35,FYTTD1,SRSF7,SRSF2,DHX38,CASC3,MIR636,CDC40,ALYREF,SRSF1,NUP50,DDX39A,NUP37,EIF4A3,THOC1,NUP107,MAGOH,THOC6,NUP42,SRSF4,ZC3H11A
R-HSA-877300	Interferon gamma signaling	0.0143767020234309	-4.24214629767767	94	40	0.0123877361412202	3229	10285	567,3665,10379,81603,6772,7341,3394,3383,818,9021,55223,3717,6737,3458,4938,53840,23650,3664,3660,3716,2209,3661,5781,3662,80128,10346,4502,23087,3459,10612,80263,5770,8554,85363,3659,117854,55128,5371,7726,10107	B2M,IRF7,IRF9,TRIM8,STAT1,SUMO1,IRF8,ICAM1,CAMK2G,SOCS3,TRIM62,JAK2,TRIM21,IFNG,OAS1,TRIM34,TRIM29,IRF6,IRF2,JAK1,FCGR1A,IRF3,PTPN11,IRF4,TRIM46,TRIM22,MT2A,TRIM35,IFNGR1,TRIM3,TRIM45,PTPN1,PIAS1,TRIM5,IRF1,TRIM6,TRIM68,PML,TRIM26,TRIM10
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.0149875789341552	-4.20053349197647	31	16	0.00495509445648808	3229	10285	7157,79837,208,5928,10000,207,53615,90809,5931,5608,3622,9219,84289,64769,2033,5371	TP53,PIP4K2C,AKT2,RBBP4,AKT3,AKT1,MBD3,PIP4P1,RBBP7,MAP2K6,ING2,MTA2,ING5,MEAF6,EP300,PML
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.0149875789341552	-4.20053349197647	31	16	0.00495509445648808	3229	10285	6635,53981,10978,6628,29894,100302196,23283,10898,25888,6637,84967,100126351,10914,22916,6634,1479	SNRPE,CPSF2,CLP1,SNRPB,CPSF1,MIR1234,CSTF2T,CPSF4,ZNF473,SNRPG,LSM10,MIR939,PAPOLA,NCBP2,SNRPD3,CSTF3
R-HSA-5339562	Uptake and actions of bacterial toxins	0.0149875789341552	-4.20053349197647	31	16	0.00495509445648808	3229	10285	928,3320,6844,9899,7296,5604,127833,5606,1938,6804,6843,3326,6616,1839,5045,5608	CD9,HSP90AA1,VAMP2,SV2B,TXNRD1,MAP2K1,SYT2,MAP2K3,EEF2,STX1A,VAMP1,HSP90AB1,SNAP25,HBEGF,FURIN,MAP2K6
R-HSA-176412	Phosphorylation of the APC/C	0.0150594489610842	-4.19574964684925	19	11	0.00340662743883555	3229	10285	8697,25906,983,29882,7321,8881,51529,29945,891,119504,246184	CDC23,ANAPC15,CDK1,ANAPC2,UBE2D1,CDC16,ANAPC11,ANAPC4,CCNB1,ANAPC16,CDC26
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	0.0150594489610842	-4.19574964684925	19	11	0.00340662743883555	3229	10285	7349,23478,43,3479,9789,51738,28972,3952,9314,60559,2688	UCN,SEC11A,ACHE,IGF1,SPCS2,GHRL,SPCS1,LEP,KLF4,SPCS3,GH1
R-HSA-8851708	Signaling by FGFR2 IIIa TM	0.0150594489610842	-4.19574964684925	19	11	0.00340662743883555	3229	10285	2963,5432,5436,5435,22916,5431,2246,5441,5438,5433,2962	GTF2F2,POLR2C,POLR2G,POLR2F,NCBP2,POLR2B,FGF1,POLR2L,POLR2I,POLR2D,GTF2F1
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.0150594489610842	-4.19574964684925	19	11	0.00340662743883555	3229	10285	7321,8881,8697,25906,991,29882,119504,246184,51343,29945,51529	UBE2D1,CDC16,CDC23,ANAPC15,CDC20,ANAPC2,ANAPC16,CDC26,FZR1,ANAPC4,ANAPC11
R-HSA-8876725	Protein methylation	0.0150594489610842	-4.19574964684925	19	11	0.00340662743883555	3229	10285	151194,1938,79091,196483,22944,2109,254013,3312,79609,6187,1915	METTL21A,EEF2,METTL22,EEF2KMT,KIN,ETFB,ETFBKMT,HSPA8,VCPKMT,RPS2,EEF1A1
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	0.015076979089093	-4.19458626212715	36	18	0.00557448126354909	3229	10285	9695,10956,11236,79139,811,2923,5700,51009,7844,6048,7311,23193,5887,6233,55741,7314,80267,84447	EDEM1,OS9,RNF139,DERL1,CALR,PDIA3,PSMC1,DERL2,RNF103,RNF5,UBA52,GANAB,RAD23B,RPS27A,EDEM2,UBB,EDEM3,SYVN1
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.015165122144869	-4.18875708348109	54	25	0.00774233508826262	3229	10285	5432,902,2968,27339,50813,64708,5438,10987,2071,5436,5435,6917,9318,7314,6233,2966,5433,7311,5441,51138,404672,1022,5431,2033,4331	POLR2C,CCNH,GTF2H4,PRPF19,COPS7A,COPS7B,POLR2I,COPS5,ERCC3,POLR2G,POLR2F,TCEA1,COPS2,UBB,RPS27A,GTF2H2,POLR2D,UBA52,POLR2L,COPS4,GTF2H5,CDK7,POLR2B,EP300,MNAT1
R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	0.0153263797119778	-4.17817977106697	78	34	0.0105295757200372	3229	10285	8790,22845,6484,6480,7903,6675,5476,64841,29906,26503,6483,55343,29925,116150,440138,2762,29880,9526,256435,1798,140838,10559,8869,29926,2673,8818,55907,5373,85365,4758,7264,6482,4597,79644	FPGT,DOLK,ST3GAL4,ST6GAL1,ST8SIA4,UAP1,CTSA,GNPNAT1,ST8SIA5,SLC17A5,ST3GAL2,SLC35C1,GMPPB,NUS1,ALG11,GMDS,ALG5,MPDU1,ST6GALNAC3,DPAGT1,NANP,SLC35A1,ST3GAL5,GMPPA,GFPT1,DPM2,CMAS,PMM2,ALG2,NEU1,GFUS,ST3GAL1,MVD,SRD5A3
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.0165533056561135	-4.10116945957443	179	70	0.0216785382471353	3229	10285	1780,27314,378,9827,9371,55738,26286,51209,9266,54732,51226,5049,60560,29127,6836,90196,3796,9342,9570,60561,22836,10945,22931,9554,79571,10671,5870,2590,83452,51272,8677,8655,55850,64837,8775,1781,11014,375,81876,51560,5861,372,51164,3797,9950,11258,8774,9267,51542,27128,10905,9341,5048,23423,9712,53407,9527,10652,11316,5050,23299,10228,2589,9367,6811,9382,10749,122830,8675,51014	DYNC1I1,RAB30,ARF4,RGP1,KIF3B,ARFGAP1,ARFGAP3,RAB9B,CYTH2,TMED9,COPZ2,PAFAH1B2,NAA35,RACGAP1,SURF4,SYS1,KIF2A,SNAP29,GOSR2,RINT1,RHOBTB3,KDELR1,RAB18,SEC22B,GCC1,DCTN6,RAB6A,GALNT2,RAB33B,BET1L,STX10,DYNLL1,USE1,KLC2,NAPA,DYNC1I2,KDELR2,ARF1,RAB1B,RAB6B,RAB1A,ARCN1,DCTN4,KIF3C,GOLGA5,DCTN3,NAPG,CYTH1,VPS54,CYTH4,MAN1A2,VAMP3,PAFAH1B1,TMED3,USP6NL,STX18,GOSR1,YKT6,COPE,PAFAH1B3,BICD2,STX6,GALNT1,RAB9A,STX5,COG1,KIF1C,NAA30,STX16,TMED7
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	0.0170255479467956	-4.07304024263067	24	13	0.00402601424589656	3229	10285	6804,6812,8541,5864,6616,8499,10815,6844,6505,6506,10550,54407,6507	STX1A,STXBP1,PPFIA3,RAB3A,SNAP25,PPFIA2,CPLX1,VAMP2,SLC1A1,SLC1A2,ARL6IP5,SLC38A2,SLC1A3
R-HSA-168928	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.0172977638946875	-4.05717804047485	84	36	0.0111489625270982	3229	10285	4790,8887,177,3440,3665,10010,1660,3093,4793,3447,3661,3446,9636,3660,1387,6285,7128,7186,7323,7311,6233,7314,57506,80143,3551,3659,7321,64135,3146,7189,23586,2033,4792,29110,3456,4615	NFKB1,TAX1BP1,AGER,IFNA2,IRF7,TANK,DHX9,UBE2K,NFKBIB,IFNA13,IRF3,IFNA10,ISG15,IRF2,CREBBP,S100B,TNFAIP3,TRAF2,UBE2D3,UBA52,RPS27A,UBB,MAVS,SIKE1,IKBKB,IRF1,UBE2D1,IFIH1,HMGB1,TRAF6,RIGI,EP300,NFKBIA,TBK1,IFNB1,MYD88
R-HSA-375276	Peptide ligand-binding receptors	0.0174947001138311	-4.04585729455941	188	73	0.0226076184577268	3229	10285	10850,3576,2147,10563,5539,3060,2833,122042,1232,6375,117579,553,6376,6019,1524,2831,6373,6750,84432,56477,680,4986,6364,6869,84539,1230,187,2919,6863,6366,4887,6352,7852,256933,10911,6363,4829,387129,283869,6870,9283,5368,4988,51738,2861,6370,2837,4295,3577,1909,6387,4283,4852,3627,5173,6368,5021,57007,2847,1233,4987,2921,50865,729230,10663,1235,4889,8862,1236,1234,6346,4886,2925	CCL27,CXCL8,F2,CXCL13,PPY,HCRT,CXCR3,RXFP2,CCR3,XCL1,RLN3,AVPR1B,CX3CL1,RLN2,CX3CR1,NPBWR1,CXCL11,SST,PROK1,CCL28,BRS3,OPRK1,CCL20,TACR1,MCHR2,CCR1,APLNR,CXCL1,TAC1,CCL21,NPY2R,CCL5,CXCR4,NPB,UTS2,CCL19,NMBR,NPSR1,NPW,TACR3,GPR37L1,PNOC,OPRM1,GHRL,GPR37,CCL25,UTS2R,MLN,CXCR1,EDNRA,CXCL12,CXCL9,NPY,CXCL10,PDYN,CCL23,OXTR,ACKR3,MCHR1,CCR4,OPRL1,CXCL3,HEBP1,CCR2,CXCR6,CCR6,NPY5R,APLN,CCR7,CCR5,CCL1,NPY1R,GRPR
R-HSA-140534	Ligand-dependent caspase activation	0.017666818911378	-4.03606703651009	17	10	0.00309693403530505	3229	10285	929,7099,148022,8743,355,356,353376,7098,23643,7186	CD14,TLR4,TICAM1,TNFSF10,FAS,FASLG,TICAM2,TLR3,LY96,TRAF2
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.0177953207979512	-4.02881973276178	322	119	0.0368535150201301	3229	10285	140,151306,2925,3350,4886,5734,2796,1234,1235,729230,50865,27334,1233,5021,1128,5173,114814,3361,170589,3972,6387,4283,4852,1268,4295,2837,2861,4988,5368,11255,1902,2797,6366,10161,4887,6352,5030,153,56477,3356,1814,54886,6750,155,6373,2831,134864,1133,6375,5032,2147,5539,10850,8698,1132,7253,6346,5731,1236,8862,4889,9170,10663,2921,27198,4987,1812,2847,6368,57007,134,319100,3627,3274,3577,1909,6370,2840,51738,6870,9283,148,64805,4829,387129,283869,154,6363,256933,10911,7852,6863,2919,187,1230,6869,6364,84539,5028,4986,680,3355,2859,5737,84432,8477,1524,6019,6376,117579,553,1232,2833,122042,5732,10563,3060,3576,1131	ADORA3,GPBAR1,GRPR,HTR1A,NPY1R,PTGER4,GNRH1,CCR5,CCR6,CCR2,HEBP1,P2RY10,CCR4,OXTR,CHRM1,PDYN,GNRHR2,HTR5A,GPHA2,LHB,CXCL12,CXCL9,NPY,CNR1,MLN,UTS2R,GPR37,OPRM1,PNOC,HRH3,LPAR1,GNRH2,CCL21,LPAR6,NPY2R,CCL5,P2RY4,ADRB1,CCL28,HTR2A,DRD3,PLPPR1,SST,ADRB3,CXCL11,NPBWR1,TAAR1,CHRM5,XCL1,P2RY11,F2,PPY,CCL27,S1PR4,CHRM4,TSHR,CCL1,PTGER1,CCR7,APLN,NPY5R,LPAR2,CXCR6,CXCL3,HCAR1,OPRL1,DRD1,MCHR1,CCL23,ACKR3,ADORA1,TAAR6,CXCL10,HRH2,CXCR1,EDNRA,CCL25,GPR17,GHRL,TACR3,GPR37L1,ADRA1A,P2RY12,NMBR,NPSR1,NPW,ADRB2,CCL19,NPB,UTS2,CXCR4,TAC1,CXCL1,APLNR,CCR1,TACR1,CCL20,MCHR2,P2RY1,OPRK1,BRS3,HTR1F,GPR35,PTGFR,PROK1,GPR65,CX3CR1,RLN2,CX3CL1,RLN3,AVPR1B,CCR3,CXCR3,RXFP2,PTGER2,CXCL13,HCRT,CXCL8,CHRM3
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.0178557119765719	-4.02543182325765	29	15	0.00464540105295757	3229	10285	5431,54514,55124,9271,113802,143689,3320,136991,84944,5441,5438,5433,5432,5436,5435	POLR2B,DDX4,PIWIL2,PIWIL1,HENMT1,PIWIL4,HSP90AA1,ASZ1,MAEL,POLR2L,POLR2I,POLR2D,POLR2C,POLR2G,POLR2F
R-HSA-422475	Axon guidance	0.0189266703836671	-3.96718322021584	549	195	0.0603902136884484	3229	10285	5683,5694,2260,122706,5685,56924,5704,7410,5689,3717,1460,5518,7314,5781,6478,10213,4690,284,5720,6711,53358,8851,5718,3716,1437,8976,285704,3673,1457,4296,116986,3559,5698,2248,51107,6900,6709,10097,152559,6477,4233,2246,2887,1848,7220,60,3897,8482,3561,5296,3326,5306,5894,27006,3845,5604,6093,4318,6386,5716,8682,3320,5290,5707,5690,3265,5516,8452,5700,8506,8986,8649,7903,5710,9037,5245,3685,3562,10109,5682,214,56963,5062,1969,25780,6464,8315,1445,1742,1020,5699,7305,3558,5705,1785,5684,5693,2051,5295,2817,5695,5709,1385,3312,5567,5578,2043,23385,8822,1944,5713,55800,6383,5664,5536,5906,4478,1173,59277,11313,783,1175,4637,2252,8503,4747,11221,1739,6324,5880,200734,1741,1839,785,9861,5721,7525,5691,5037,5529,160,5686,10486,8074,4756,1400,5525,391,998,7529,84292,55715,7311,6327,5908,5588,1946,2255,7074,103910,1852,6714,9475,10817,5687,8829,5621,3567,2549,388,28956,3815,55851,57144,10094,7450,818,6655,55816,3560,1272,784,8823,161742,1072,6233,1947,10627,5702,7422,220164,1843,10154,7979,5692	PSMA2,PSMB6,FGFR1,PSMB11,PSMA4,PAK6,PSMC4,VAV2,PSMB1,JAK2,CSNK2B,PPP2R1A,UBB,PTPN11,SIAH2,PSMD14,NCK1,ANGPT1,PSME1,SPTBN1,SHC3,CDK5R1,PSMD12,JAK1,CSF2,WASL,RGMB,ITGA2,CSNK2A1,MAP3K11,AGAP2,IL2RA,PSMB9,FGF3,APH1A,CNTN2,SPTAN1,ACTR2,PAQR3,SIAH1,MET,FGF1,GRB10,DUSP6,TRPC1,ACTB,L1CAM,SEMA7A,IL2RG,PIK3R2,HSP90AB1,PITPNA,RAF1,FGF22,KRAS,MAP2K1,ROCK1,MMP9,SDCBP,PSMD10,PEA15,HSP90AA1,PIK3CA,PSMD1,PSMB2,HRAS,PPP2CB,CUL3,PSMC1,CNTNAP1,RPS6KA4,LAMTOR3,ST8SIA4,PSMD4,SEMA5A,PHB1,ITGAV,IL3,ARPC2,PSMA1,ALCAM,RGMA,PAK2,EPHA2,RASGRP3,SHC1,BRAP,CSK,DLG4,CDK5,PSMB10,TYROBP,IL2,PSMC5,DNM2,PSMA3,PSMB5,EPHB6,PIK3R1,GPC1,PSMB7,PSMD3,CREB1,HSPA8,PRKACB,PRKCA,EPHA4,NCSTN,FGF17,EFNA3,PSMD7,SCN3B,SDC2,PSEN2,PPP5C,RAP1A,MSN,AP2M1,NTN4,LYPLA2,CACNB2,AP2S1,MYL6,FGF7,PIK3R3,NEFL,DUSP10,DLG1,SCN1B,RAC2,SPRED2,DLG3,HBEGF,CACNB4,PSMD6,PSME2,YES1,PSMB3,PEBP1,PPP2R5E,AP2A1,PSMA5,CAP2,FGF23,NEO1,CRMP1,PPP2R5A,RHOG,CDC42,YWHAB,WDR83,DOK4,UBA52,SCN2B,RAP1B,PRKCQ,EFNA5,FGF10,TIAM1,MYL12B,DUSP9,SRC,ROCK2,FRS3,PSMA6,NRP1,PRNP,IL5,GAB1,RHOB,LAMTOR2,KIT,PSENEN,PAK5,ARPC3,VWF,CAMK2G,SOS2,DOK5,IL2RB,CNTN1,CACNB3,FGF16,SPRED1,CFL1,RPS27A,EFNB1,MYL12A,PSMC3,VEGFA,DOK6,DUSP1,PLXNC1,SEM1,PSMB4
R-HSA-6807878	COPI-mediated anterograde transport	0.0189611347121314	-3.9653639362598	79	34	0.0105295757200372	3229	10285	8775,1780,11014,2348,1781,378,375,81876,5861,11070,55738,6709,26286,372,51164,51226,966,8774,11258,54732,10945,9570,23423,6711,10671,9527,10652,51272,11316,9382,6811,51014,8655,10282	NAPA,DYNC1I1,KDELR2,FOLR1,DYNC1I2,ARF4,ARF1,RAB1B,RAB1A,TMEM115,ARFGAP1,SPTAN1,ARFGAP3,ARCN1,DCTN4,COPZ2,CD59,NAPG,DCTN3,TMED9,KDELR1,GOSR2,TMED3,SPTBN1,DCTN6,GOSR1,YKT6,BET1L,COPE,COG1,STX5,TMED7,DYNLL1,BET1
R-HSA-375165	NCAM signaling for neurite out-growth	0.0196529397892954	-3.92952834425924	276	103	0.031898420563642	3229	10285	5682,5702,161742,5710,5245,3562,6233,5692,25780,6464,1843,7979,3567,3265,3815,28956,5516,5687,8682,5621,5690,5707,8649,818,3560,7903,784,8823,5700,8452,7450,3845,5604,5908,5894,84292,7311,27006,1852,6714,5716,10817,2255,5686,8074,152559,4233,5691,5037,6900,5529,6709,3561,5525,2246,1848,7529,4296,4747,11221,1839,9861,785,5721,2248,3559,200734,5698,783,5906,53358,1437,5718,2252,3716,10213,5518,7314,284,5720,5536,6711,8822,5713,5699,2260,5705,3558,122706,5685,8315,1445,1742,5683,5694,5689,5695,3717,5709,1385,5704,5684,5693	PSMA1,PSMC3,SPRED1,PSMD4,PHB1,IL3,RPS27A,PSMB4,RASGRP3,SHC1,DUSP1,SEM1,IL5,HRAS,KIT,LAMTOR2,PPP2CB,PSMA6,PEA15,PRNP,PSMB2,PSMD1,LAMTOR3,CAMK2G,IL2RB,ST8SIA4,CACNB3,FGF16,PSMC1,CUL3,VWF,KRAS,MAP2K1,RAP1B,RAF1,WDR83,UBA52,FGF22,DUSP9,SRC,PSMD10,FRS3,FGF10,PSMA5,FGF23,PAQR3,MET,PSMB3,PEBP1,CNTN2,PPP2R5E,SPTAN1,IL2RG,PPP2R5A,FGF1,DUSP6,YWHAB,MAP3K11,NEFL,DUSP10,HBEGF,PSMD6,CACNB4,PSME2,FGF3,IL2RA,SPRED2,PSMB9,CACNB2,RAP1A,SHC3,CSF2,PSMD12,FGF7,JAK1,PSMD14,PPP2R1A,UBB,ANGPT1,PSME1,PPP5C,SPTBN1,FGF17,PSMD7,PSMB10,FGFR1,PSMC5,IL2,PSMB11,PSMA4,BRAP,CSK,DLG4,PSMA2,PSMB6,PSMB1,PSMB7,JAK2,PSMD3,CREB1,PSMC4,PSMA3,PSMB5
R-HSA-157579	Telomere Maintenance	0.0200584563761386	-3.90910444975122	82	35	0.0108392691235677	3229	10285	23649,8607,3015,56655,94239,474382,57804,3013,5982,8342,6118,8970,5425,55766,10856,2237,8348,3014,5983,8335,85236,55135,1736,5985,6119,55651,5984,5558,8345,8334,255626,8331,54107,7015,5111	POLA2,RUVBL1,H2AZ1,POLE4,H2AZ2,H2AB1,POLD4,H2AC7,RFC2,H2BC14,RPA2,H2BC11,POLD2,H2AJ,RUVBL2,FEN1,H2BC17,H2AX,RFC3,H2AC4,H2BC12,WRAP53,DKC1,RFC5,RPA3,NHP2,RFC4,PRIM2,H2BC9,H2AC6,H2BC1,H2AC14,POLE3,TERT,PCNA
R-HSA-901032	ER Quality Control Compartment (ERQC)	0.0202508446110364	-3.89955877711241	22	12	0.00371632084236606	3229	10285	9695,10956,11236,7311,6233,84447,7314,80267,55741,51009,7844,6048	EDEM1,OS9,RNF139,UBA52,RPS27A,SYVN1,UBB,EDEM3,EDEM2,DERL2,RNF103,RNF5
R-HSA-111447	Activation of BAD and translocation to mitochondria	0.0206646272526081	-3.87933186879989	15	9	0.00278724063177454	3229	10285	7532,572,2810,208,7529,7533,7534,207,10000	YWHAG,BAD,SFN,AKT2,YWHAB,YWHAH,YWHAZ,AKT1,AKT3
R-HSA-205043	NRIF signals cell death from the nucleus	0.0206646272526081	-3.87933186879989	15	9	0.00278724063177454	3229	10285	6233,7311,23385,8878,55851,7314,51107,5664,7189	RPS27A,UBA52,NCSTN,SQSTM1,PSENEN,UBB,APH1A,PSEN2,TRAF6
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.0211198491900511	-3.85754196079215	50	23	0.00712294828120161	3229	10285	2968,902,5432,5438,2962,1025,6749,2071,2963,6921,5436,6827,5435,6917,5433,404672,5441,2966,1022,5431,22916,6829,4331	GTF2H4,CCNH,POLR2C,POLR2I,GTF2F1,CDK9,SSRP1,ERCC3,GTF2F2,ELOC,POLR2G,SUPT4H1,POLR2F,TCEA1,POLR2D,GTF2H5,POLR2L,GTF2H2,CDK7,POLR2B,NCBP2,SUPT5H,MNAT1
R-HSA-167169	HIV Transcription Elongation	0.0211198491900511	-3.85754196079215	50	23	0.00712294828120161	3229	10285	1025,1022,4331,6749,5431,22916,2071,6829,5435,2968,2963,902,6921,5432,5436,6827,5433,404672,5441,5438,2962,2966,6917	CDK9,CDK7,MNAT1,SSRP1,POLR2B,NCBP2,ERCC3,SUPT5H,POLR2F,GTF2H4,GTF2F2,CCNH,ELOC,POLR2C,POLR2G,SUPT4H1,POLR2D,GTF2H5,POLR2L,POLR2I,GTF2F1,GTF2H2,TCEA1
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.0211198491900511	-3.85754196079215	50	23	0.00712294828120161	3229	10285	22916,5431,6749,6829,2071,4331,1022,1025,6917,404672,5441,5438,5433,2966,2962,2963,2968,6827,902,5436,6921,5432,5435	NCBP2,POLR2B,SSRP1,SUPT5H,ERCC3,MNAT1,CDK7,CDK9,TCEA1,GTF2H5,POLR2L,POLR2I,POLR2D,GTF2H2,GTF2F1,GTF2F2,GTF2H4,SUPT4H1,CCNH,POLR2G,ELOC,POLR2C,POLR2F
R-HSA-390466	Chaperonin-mediated protein folding	0.0219534236891869	-3.81883217489573	99	41	0.0126974295447507	3229	10285	10694,51764,2785,2773,2787,2791,6468,2775,2790,10576,2771,7846,5082,60,9628,5202,2781,1460,2784,2793,2782,5204,7157,1457,5201,59345,2788,22948,55970,6950,8841,55135,54331,55294,10383,5203,26224,10574,406974,10471,10376	CCT8,GNG13,GNG3,GNAI3,GNG5,GNG11,FBXW4,GNAO1,GNG10,CCT2,GNAI2,TUBA1A,PDCL,ACTB,RGS6,PFDN2,GNAZ,CSNK2B,GNB3,GNGT2,GNB1,PFDN5,TP53,CSNK2A1,PFDN1,GNB4,GNG7,CCT5,GNG12,TCP1,HDAC3,WRAP53,GNG2,FBXW7,TUBB4B,PFDN4,FBXL3,CCT7,MIR197,PFDN6,TUBA1B
R-HSA-167172	Transcription of the HIV genome	0.0220234429200517	-3.81564780568387	77	33	0.0102198823165067	3229	10285	6873,6829,5431,22916,4331,2960,1022,2961,6917,2966,5433,404672,5441,5436,6921,6827,6880,2958,2963,5435,6879,6881,2071,6749,2959,6882,1025,2962,5438,902,5432,2968,2957	TAF2,SUPT5H,POLR2B,NCBP2,MNAT1,GTF2E1,CDK7,GTF2E2,TCEA1,GTF2H2,POLR2D,GTF2H5,POLR2L,POLR2G,ELOC,SUPT4H1,TAF9,GTF2A2,GTF2F2,POLR2F,TAF7,TAF10,ERCC3,SSRP1,GTF2B,TAF11,CDK9,GTF2F1,POLR2I,CCNH,POLR2C,GTF2H4,GTF2A1
R-HSA-211859	Biological oxidations	0.0230405222759139	-3.77050077518594	222	84	0.0260142458965624	3229	10285	7360,79799,51302,373156,55748,2327,1565,54996,124,6818,64816,1558,9446,126410,4258,389396,2946,54658,79017,1581,2939,27306,1593,1584,1589,653689,23169,2052,66002,2328,2949,125,84836,10249,5447,80777,1312,1800,1594,10728,1586,874,2941,120227,1585,8574,2686,494143,4144,64180,2729,2326,27284,1592,55347,2948,27430,7358,1572,55902,1545,134147,1727,11283,119391,2950,2938,3326,1543,51504,4259,196743,9060,1559,2952,2947,9049,285440,51000,1562,10,1577,10327,2098	UGP2,UGT2A3,CYP39A1,GSTK1,CNDP2,FMO2,CYP2D6,MTARC2,ADH1A,SULT1A3,CYP3A43,CYP2C8,GSTO1,CYP4F22,MGST2,GLYATL3,GSTM2,UGT1A1,GGCT,CYP7A1,GSTA2,HPGDS,CYP27A1,CYP11B1,CYP21A2,GSTT2B,SLC35D1,EPHX1,CYP4F12,FMO3,GSTM5,ADH1B,ABHD14B,GLYAT,POR,CYB5B,COMT,DPEP1,CYP27B1,PTGES3,CYP17A1,CBR3,GSTA4,CYP2R1,CYP11B2,AKR7A2,GGT7,CHAC2,MAT2A,DPEP3,GCLC,FMO1,SULT1B1,CYP26A1,ABHD10,GSTM4,MAT2B,UGDH,CYP2F1,ACSS2,CYP1B1,CMBL,CYB5R3,CYP4F8,GSTO2,GSTP1,GSTA1,HSP90AB1,CYP1A1,TRMT112,MGST3,PAOX,PAPSS2,CYP2C9,GSTT1,GSTM3,AIP,CYP4V2,SLC35B3,CYP2C18,NAT2,CYP3A5,AKR1A1,ESD
R-HSA-5654741	Signaling by FGFR3	0.0238254412537984	-3.73700130899225	40	19	0.00588417466707959	3229	10285	7311,6233,7314,5290,867,5518,5516,2549,3265,8074,3845,5781,8822,2246,8823,6464,10817,5295,6714	UBA52,RPS27A,UBB,PIK3CA,CBL,PPP2R1A,PPP2CB,GAB1,HRAS,FGF23,KRAS,PTPN11,FGF17,FGF1,FGF16,SHC1,FRS3,PIK3R1,SRC
R-HSA-198323	AKT phosphorylates targets in the cytosol	0.0240556250631783	-3.72738641941761	13	8	0.00247754722824404	3229	10285	10000,207,1027,4193,208,1026,572,2931	AKT3,AKT1,CDKN1B,MDM2,AKT2,CDKN1A,BAD,GSK3A
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	0.0240556250631783	-3.72738641941761	13	8	0.00247754722824404	3229	10285	208,9101,10193,10000,207,7314,6233,7311	AKT2,USP8,RNF41,AKT3,AKT1,UBB,RPS27A,UBA52
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	0.0240556250631783	-3.72738641941761	13	8	0.00247754722824404	3229	10285	7184,3309,811,468,4800,1649,4801,7494	HSP90B1,HSPA5,CALR,ATF4,NFYA,DDIT3,NFYB,XBP1
R-HSA-2029481	FCGR activation	0.0240556250631783	-3.72738641941761	13	8	0.00247754722824404	3229	10285	2209,6850,2212,7525,919,917,6714,2268	FCGR1A,SYK,FCGR2A,YES1,CD247,CD3G,SRC,FGR
R-HSA-1643713	Signaling by EGFR in Cancer	0.0241097742390178	-3.72513795062312	20	11	0.00340662743883555	3229	10285	6233,7311,3320,867,5290,7314,3265,2549,6464,3845,5295	RPS27A,UBA52,HSP90AA1,CBL,PIK3CA,UBB,HRAS,GAB1,SHC1,KRAS,PIK3R1
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.0241097742390178	-3.72513795062312	20	11	0.00340662743883555	3229	10285	5295,6464,3845,3265,2549,7314,3320,5290,867,7311,6233	PIK3R1,SHC1,KRAS,HRAS,GAB1,UBB,HSP90AA1,PIK3CA,CBL,UBA52,RPS27A
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.0241097742390178	-3.72513795062312	20	11	0.00340662743883555	3229	10285	6464,2549,3265,5295,3845,7311,6233,7314,3320,5290,867	SHC1,GAB1,HRAS,PIK3R1,KRAS,UBA52,RPS27A,UBB,HSP90AA1,PIK3CA,CBL
R-HSA-450294	MAP kinase activation in TLR cascade	0.0248598502882315	-3.69450121511274	64	28	0.00867141529885413	3229	10285	6233,7311,5518,7314,4208,5604,5606,3551,1845,6500,7189,4205,23291,4790,5516,3725,7335,10454,5602,2353,7334,1848,466,2002,23118,1385,7867,5608	RPS27A,UBA52,PPP2R1A,UBB,MEF2C,MAP2K1,MAP2K3,IKBKB,DUSP3,SKP1,TRAF6,MEF2A,FBXW11,NFKB1,PPP2CB,JUN,UBE2V1,TAB1,MAPK10,FOS,UBE2N,DUSP6,ATF1,ELK1,TAB2,CREB1,MAPKAPK3,MAP2K6
R-HSA-163685	Integration of energy metabolism	0.0253411323958457	-3.67532641701163	111	45	0.0139362031588727	3229	10285	3767,55970,3745,54331,10554,2788,31,6794,1131,2782,5567,5578,5518,51094,2767,6616,10768,109,6804,9370,2787,291,23236,2790,23568,108,51764,79602,5330,59345,784,6513,2793,2784,6812,2771,292,2776,2791,5516,9630,783,2785,5906,6844	KCNJ11,GNG12,KCNB1,GNG2,AGPAT1,GNG7,ACACA,STK11,CHRM3,GNB1,PRKACB,PRKCA,PPP2R1A,ADIPOR1,GNA11,SNAP25,AHCYL1,ADCY3,STX1A,ADIPOQ,GNG5,SLC25A4,PLCB1,GNG10,ARL2BP,ADCY2,GNG13,ADIPOR2,PLCB2,GNB4,CACNB3,SLC2A1,GNGT2,GNB3,STXBP1,GNAI2,SLC25A5,GNAQ,GNG11,PPP2CB,GNA14,CACNB2,GNG3,RAP1A,VAMP2
R-HSA-1296041	Activation of G protein gated Potassium channels	0.0254515344588006	-3.67097924472652	25	13	0.00402601424589656	3229	10285	2793,2784,3766,55970,54331,2787,2790,2788,3760,3759,2550,2782,2785	GNGT2,GNB3,KCNJ10,GNG12,GNG2,GNG5,GNG10,GNG7,KCNJ3,KCNJ2,GABBR1,GNB1,GNG3
R-HSA-499943	Synthesis and interconversion of nucleotide di- and triphosphates	0.0254515344588006	-3.67097924472652	25	13	0.00402601424589656	3229	10285	79077,26289,4831,51727,4830,6240,2987,204,1841,2745,7295,4833,7296	DCTPP1,AK5,NME2,CMPK1,NME1,RRM1,GUK1,AK2,DTYMK,GLRX,TXN,NME4,TXNRD1
R-HSA-997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.0254515344588006	-3.67097924472652	25	13	0.00402601424589656	3229	10285	2787,2790,2788,3760,3759,2782,2550,2785,2793,2784,3766,55970,54331	GNG5,GNG10,GNG7,KCNJ3,KCNJ2,GNB1,GABBR1,GNG3,GNGT2,GNB3,KCNJ10,GNG12,GNG2
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.0254515344588006	-3.67097924472652	25	13	0.00402601424589656	3229	10285	7098,3146,177,148022,3551,4790,4793,4615,29110,4792,6285,1660,3661	TLR3,HMGB1,AGER,TICAM1,IKBKB,NFKB1,NFKBIB,MYD88,TBK1,NFKBIA,S100B,DHX9,IRF3
R-HSA-1296059	G protein gated Potassium channels	0.0254515344588006	-3.67097924472652	25	13	0.00402601424589656	3229	10285	2790,2788,3760,2787,2785,3759,2782,2550,2793,2784,54331,3766,55970	GNG10,GNG7,KCNJ3,GNG5,GNG3,KCNJ2,GNB1,GABBR1,GNGT2,GNB3,GNG2,KCNJ10,GNG12
R-HSA-162588	Budding and maturation of HIV virion	0.0254515344588006	-3.67097924472652	25	13	0.00402601424589656	3229	10285	51160,25978,92421,9525,5478,51534,27183,7251,7311,6233,7314,51510,27243	VPS28,CHMP2B,CHMP4C,VPS4B,PPIA,VTA1,VPS4A,TSG101,UBA52,RPS27A,UBB,CHMP5,CHMP2A
R-HSA-6799198	Complex I biogenesis	0.0272925681640807	-3.60114084227406	51	23	0.00712294828120161	3229	10285	4729,4698,4713,4716,91942,25915,4720,4726,4711,4714,4710,29078,4718,4712,137682,4695,55863,4722,4694,51300,4706,55967,4728	NDUFV2,NDUFA5,NDUFB7,NDUFB10,NDUFAF2,NDUFAF3,NDUFS2,NDUFS6,NDUFB5,NDUFB8,NDUFB4,NDUFAF4,NDUFC2,NDUFB6,NDUFAF6,NDUFA2,TMEM126B,NDUFS3,NDUFA1,TIMMDC1,NDUFAB1,NDUFA12,NDUFS8
R-HSA-77588	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	0.027778240354144	-3.58350228584558	11	7	0.00216785382471353	3229	10285	6634,22916,25888,84967,6637,6628,6635	SNRPD3,NCBP2,ZNF473,LSM10,SNRPG,SNRPB,SNRPE
R-HSA-70326	Glucose metabolism	0.0282630609585152	-3.5661995934188	81	34	0.0105295757200372	3229	10285	5223,2026,6576,2997,5208,2023,5837,5255,5106,4190,10007,8604,7360,5834,5516,2203,669,8789,5257,132789,5507,5236,5091,5260,7311,5567,6233,7314,2632,8402,5518,2597,1468,5230	PGAM1,ENO2,SLC25A1,GYS1,PFKFB2,ENO1,PYGM,PHKA1,PCK2,MDH1,GNPDA1,SLC25A12,UGP2,PYGB,PPP2CB,FBP1,BPGM,FBP2,PHKB,GNPDA2,PPP1R3C,PGM1,PC,PHKG1,UBA52,PRKACB,RPS27A,UBB,GBE1,SLC25A11,PPP2R1A,GAPDH,SLC25A10,PGK1
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	0.0290494844686902	-3.53875454218625	62	27	0.00836172189532363	3229	10285	55770,51552,9882,149371,4619,55763,7533,8766,7534,5564,4620,11336,7532,208,2810,5867,5872,6844,207,8773,23216,7529,57186,5898,9371,5571,10640	EXOC2,RAB14,TBC1D4,EXOC8,MYH1,EXOC1,YWHAH,RAB11A,YWHAZ,PRKAB1,MYH2,EXOC3,YWHAG,AKT2,SFN,RAB4A,RAB13,VAMP2,AKT1,SNAP23,TBC1D1,YWHAB,RALGAPA2,RALA,KIF3B,PRKAG1,EXOC5
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.029674183847426	-3.51747784189997	73	31	0.00960049550944565	3229	10285	2957,57117,6619,5432,2962,5438,1025,2959,6882,6617,5435,5436,6880,2958,2963,5433,5441,64859,2961,58490,51808,2960,1022,6667,55197,10302,79871,6618,55174,5431,22916	GTF2A1,INTS12,SNAPC3,POLR2C,GTF2F1,POLR2I,CDK9,GTF2B,TAF11,SNAPC1,POLR2F,POLR2G,TAF9,GTF2A2,GTF2F2,POLR2D,POLR2L,NABP1,GTF2E2,RPRD1B,PHAX,GTF2E1,CDK7,SP1,RPRD1A,SNAPC5,RPAP2,SNAPC2,INTS10,POLR2B,NCBP2
R-HSA-389356	CD28 co-stimulation	0.0296803730074089	-3.51726929312686	33	16	0.00495509445648808	3229	10285	9402,208,942,5290,7525,207,10000,940,9020,5296,5295,6714,8503,5062,998,941	GRAP2,AKT2,CD86,PIK3CA,YES1,AKT1,AKT3,CD28,MAP3K14,PIK3R2,PIK3R1,SRC,PIK3R3,PAK2,CDC42,CD80
R-HSA-5654695	PI-3K cascade:FGFR2	0.0304633856209786	-3.49122978795514	23	12	0.00371632084236606	3229	10285	2252,2246,2255,8822,2248,8823,5295,27006,5290,2549,5781,8074	FGF7,FGF1,FGF10,FGF17,FGF3,FGF16,PIK3R1,FGF22,PIK3CA,GAB1,PTPN11,FGF23
R-HSA-112409	RAF-independent MAPK1/3 activation	0.0304633856209786	-3.49122978795514	23	12	0.00371632084236606	3229	10285	5781,1852,983,5604,3717,8682,11221,1843,3572,1848,3569,3716	PTPN11,DUSP9,CDK1,MAP2K1,JAK2,PEA15,DUSP10,DUSP1,IL6ST,DUSP6,IL6,JAK1
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.0304633856209786	-3.49122978795514	23	12	0.00371632084236606	3229	10285	8573,8224,64130,6844,10815,8541,6812,8499,5864,6616,55327,6804	CASK,SYN3,LIN7B,VAMP2,CPLX1,PPFIA3,STXBP1,PPFIA2,RAB3A,SNAP25,LIN7C,STX1A
R-HSA-6803529	FGFR2 alternative splicing	0.0305371000044792	-3.48881294098659	28	14	0.00433570764942707	3229	10285	3185,5433,5441,3178,5438,2962,5431,22916,7072,5435,2963,5436,5432,23543	HNRNPF,POLR2D,POLR2L,HNRNPA1,POLR2I,GTF2F1,POLR2B,NCBP2,TIA1,POLR2F,GTF2F2,POLR2G,POLR2C,RBFOX2
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	0.0305371000044792	-3.48881294098659	28	14	0.00433570764942707	3229	10285	6785,9200,79071,2182,401494,83401,9524,201562,693224,79993,3293,51495,64834,5538	ELOVL4,HACD1,ELOVL6,ACSL4,HACD4,ELOVL3,TECR,HACD2,MIR639,ELOVL7,HSD17B3,HACD3,ELOVL1,PPT1
R-HSA-264876	Insulin processing	0.0305371000044792	-3.48881294098659	28	14	0.00433570764942707	3229	10285	64924,30001,5873,149371,148867,5126,55770,6844,55763,1363,10640,11336,57393,6804	SLC30A5,ERO1A,RAB27A,EXOC8,SLC30A7,PCSK2,EXOC2,VAMP2,EXOC1,CPE,EXOC5,EXOC3,CLTRN,STX1A
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	4088,4087,4089	SMAD3,SMAD2,SMAD4
R-HSA-5602680	MyD88 deficiency (TLR5)	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	51135,4615,7100	IRAK4,MYD88,TLR5
R-HSA-190827	Transport of connexins along the secretory pathway	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	2706,2705,2697	GJB2,GJB1,GJA1
R-HSA-217271	FMO oxidises nucleophiles	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	2328,2327,2326	FMO3,FMO2,FMO1
R-HSA-173599	Formation of the active cofactor, UDP-glucuronate	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	23169,7360,7358	SLC35D1,UGP2,UGDH
R-HSA-444411	Rhesus glycoproteins mediate ammonium transport.	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	51458,57127,6005	RHCG,RHBG,RHAG
R-HSA-350864	Regulation of thyroid hormone activity	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	1735,1733,1734	DIO3,DIO1,DIO2
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	4089,4087,4088	SMAD4,SMAD2,SMAD3
R-HSA-190704	Oligomerization of connexins into connexons	0.0309253295758102	-3.47617970349893	3	3	0.000929080210591514	3229	10285	2697,2705,2706	GJA1,GJB1,GJB2
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	0.0316194982006952	-3.45398131700747	9	6	0.00185816042118303	3229	10285	2159,5627,2155,2147,632,2158	F10,PROS1,F7,F2,BGLAP,F9
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	0.0316262199378437	-3.45376875756877	41	19	0.00588417466707959	3229	10285	54107,5111,5984,6118,7314,6233,5425,7311,57804,5985,25898,6119,5982,9768,7353,5983,9636,10459,56655	POLE3,PCNA,RFC4,RPA2,UBB,RPS27A,POLD2,UBA52,POLD4,RFC5,RCHY1,RPA3,RFC2,PCLAF,UFD1,RFC3,ISG15,MAD2L2,POLE4
R-HSA-5696400	Dual Incision in GG-NER	0.0316262199378437	-3.45376875756877	41	19	0.00588417466707959	3229	10285	2968,54107,5111,5984,10038,7314,6118,5425,6233,2966,7311,404672,57804,5985,6119,5982,2071,5983,56655	GTF2H4,POLE3,PCNA,RFC4,PARP2,UBB,RPA2,POLD2,RPS27A,GTF2H2,UBA52,GTF2H5,POLD4,RFC5,RPA3,RFC2,ERCC3,RFC3,POLE4
R-HSA-5654743	Signaling by FGFR4	0.0316262199378437	-3.45376875756877	41	19	0.00588417466707959	3229	10285	7311,6233,7314,5518,5290,867,2549,3265,5516,8074,5781,3845,2246,8822,6464,8823,10817,6714,5295	UBA52,RPS27A,UBB,PPP2R1A,PIK3CA,CBL,GAB1,HRAS,PPP2CB,FGF23,PTPN11,KRAS,FGF1,FGF17,SHC1,FGF16,FRS3,SRC,PIK3R1
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.032151828008755	-3.43728597116669	49	22	0.00681325487767111	3229	10285	1647,891,2033,5325,1027,28984,9337,4848,983,1026,1874,7832,890,57060,7029,246175,29883,581,2810,5111,7157,57472	GADD45A,CCNB1,EP300,PLAGL1,CDKN1B,RGCC,CNOT8,CNOT2,CDK1,CDKN1A,E2F4,BTG2,CCNA2,PCBP4,TFDP2,CNOT6L,CNOT7,BAX,SFN,PCNA,TP53,CNOT6
R-HSA-2559583	Cellular Senescence	0.0329250301917086	-3.4135221143689	196	74	0.0229173118612574	3229	10285	51343,4683,6667,8335,3009,29945,3456,7321,29882,8550,29855,25906,8697,8345,6233,2146,4001,7029,51529,890,7157,8331,255626,8334,1031,5602,3015,119504,1911,7290,3013,1026,5608,94239,7867,474382,5928,1021,3014,8726,3159,55766,4343,5606,25842,85236,26523,246184,7311,6015,57690,3576,7314,5925,3007,2353,4193,3024,3569,1027,1032,3397,1019,8881,5931,8350,23043,3552,8342,8970,4790,8348,7295,3725	FZR1,NBN,SP1,H2AC4,H1-5,ANAPC4,IFNB1,UBE2D1,ANAPC2,MAPKAPK5,UBN1,ANAPC15,CDC23,H2BC9,RPS27A,EZH2,LMNB1,TFDP2,ANAPC11,CCNA2,TP53,H2AC14,H2BC1,H2AC6,CDKN2C,MAPK10,H2AZ1,ANAPC16,PHC1,HIRA,H2AC7,CDKN1A,MAP2K6,H2AZ2,MAPKAPK3,H2AB1,RBBP4,CDK6,H2AX,EED,HMGA1,H2AJ,MOV10,MAP2K3,ASF1A,H2BC12,AGO1,CDC26,UBA52,RING1,TNRC6C,CXCL8,UBB,RB1,H1-3,FOS,MDM2,H1-1,IL6,CDKN1B,CDKN2D,ID1,CDK4,CDC16,RBBP7,H3C1,TNIK,IL1A,H2BC14,H2BC11,NFKB1,H2BC17,TXN,JUN
R-HSA-418038	Nucleotide-like (purinergic) receptors	0.0342706992806038	-3.37346453826721	16	9	0.00278724063177454	3229	10285	5030,64805,10161,27334,2840,5028,134,140,5032	P2RY4,P2RY12,LPAR6,P2RY10,GPR17,P2RY1,ADORA1,ADORA3,P2RY11
R-HSA-5686938	Regulation of TLR by endogenous ligand	0.0342706992806038	-3.37346453826721	16	9	0.00278724063177454	3229	10285	929,7099,7096,10333,6279,948,7097,23643,3146	CD14,TLR4,TLR1,TLR6,S100A8,CD36,TLR2,LY96,HMGB1
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.0347473514638857	-3.35965192674259	52	23	0.00712294828120161	3229	10285	6917,2966,5433,5441,404672,6921,5436,6827,2963,5435,6829,5431,22916,4331,1022,2962,5438,902,5432,2968,2071,6749,1025	TCEA1,GTF2H2,POLR2D,POLR2L,GTF2H5,ELOC,POLR2G,SUPT4H1,GTF2F2,POLR2F,SUPT5H,POLR2B,NCBP2,MNAT1,CDK7,GTF2F1,POLR2I,CCNH,POLR2C,GTF2H4,ERCC3,SSRP1,CDK9
R-HSA-3065678	SUMO is transferred from E1 to E2 (UBE2I, UBC9)	0.034997111713186	-3.35248974337829	7	5	0.00154846701765252	3229	10285	6612,7329,25950,6613,7341	SUMO3,UBE2I,RWDD3,SUMO2,SUMO1
R-HSA-1296065	Inwardly rectifying K+ channels	0.0354353927353953	-3.34004416351916	31	15	0.00464540105295757	3229	10285	2785,2782,2550,3759,3764,3760,2788,2790,2787,54331,55970,3766,2793,2784,3767	GNG3,GNB1,GABBR1,KCNJ2,KCNJ8,KCNJ3,GNG7,GNG10,GNG5,GNG2,GNG12,KCNJ10,GNGT2,GNB3,KCNJ11
R-HSA-73772	RNA Polymerase I Promoter Escape	0.0354353927353953	-3.34004416351916	31	15	0.00464540105295757	3229	10285	1022,100302240,2071,4331,51082,2968,902,79101,5435,54700,404672,30834,5441,84172,2966	CDK7,MIR1304,ERCC3,MNAT1,POLR1D,GTF2H4,CCNH,TAF1D,POLR2F,RRN3,GTF2H5,POLR1H,POLR2L,POLR1B,GTF2H2
R-HSA-111885	Opioid Signalling	0.0354478684811998	-3.33969215528141	85	35	0.0108392691235677	3229	10285	5518,5530,4988,5567,5578,2782,84152,59345,2788,54331,5142,55970,5153,406974,5173,5330,2773,2785,108,1020,51764,5136,2775,2790,2787,2791,5516,23236,109,2771,10768,2793,2784,2781,1385	PPP2R1A,PPP3CA,OPRM1,PRKACB,PRKCA,GNB1,PPP1R1B,GNB4,GNG7,GNG2,PDE4B,GNG12,PDE1B,MIR197,PDYN,PLCB2,GNAI3,GNG3,ADCY2,CDK5,GNG13,PDE1A,GNAO1,GNG10,GNG5,GNG11,PPP2CB,PLCB1,ADCY3,GNAI2,AHCYL1,GNGT2,GNB3,GNAZ,CREB1
R-HSA-140834	Extrinsic Pathway of Fibrin Clot Formation	0.0363398281122232	-3.31484094601365	5	4	0.00123877361412202	3229	10285	2155,2158,7035,2159	F7,F9,TFPI,F10
R-HSA-390648	Muscarinic acetylcholine receptors	0.0363398281122232	-3.31484094601365	5	4	0.00123877361412202	3229	10285	1133,1128,1131,1132	CHRM5,CHRM1,CHRM3,CHRM4
R-HSA-180689	APOBEC3G mediated resistance to HIV-1 infection	0.0363398281122232	-3.31484094601365	5	4	0.00123877361412202	3229	10285	3159,8815,60489,5478	HMGA1,BANF1,APOBEC3G,PPIA
R-HSA-1300652	Sperm:Oocyte Membrane Binding	0.0363398281122232	-3.31484094601365	5	4	0.00123877361412202	3229	10285	928,113177,284359,126123	CD9,IZUMO4,IZUMO1,IZUMO2
R-HSA-5654689	PI-3K cascade:FGFR1	0.0365360075051095	-3.30945699768263	21	11	0.00340662743883555	3229	10285	5290,27006,2260,8074,5781,2549,2246,2255,8822,5295,2248	PIK3CA,FGF22,FGFR1,FGF23,PTPN11,GAB1,FGF1,FGF10,FGF17,PIK3R1,FGF3
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.0365360075051095	-3.30945699768263	21	11	0.00340662743883555	3229	10285	4792,4615,1660,6285,148022,4793,4790,3551,7098,177,3146	NFKBIA,MYD88,DHX9,S100B,TICAM1,NFKBIB,NFKB1,IKBKB,TLR3,AGER,HMGB1
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.0367748494372216	-3.30294110666422	88	36	0.0111489625270982	3229	10285	404672,5441,5433,2966,6917,6881,6879,5435,2963,2958,6880,6827,5436,6921,4331,22916,55840,5431,6829,6873,2961,1022,2960,5438,2962,79577,2957,80349,2968,902,5432,6882,2959,6749,2071,1025	GTF2H5,POLR2L,POLR2D,GTF2H2,TCEA1,TAF10,TAF7,POLR2F,GTF2F2,GTF2A2,TAF9,SUPT4H1,POLR2G,ELOC,MNAT1,NCBP2,EAF2,POLR2B,SUPT5H,TAF2,GTF2E2,CDK7,GTF2E1,POLR2I,GTF2F1,CDC73,GTF2A1,SKIC8,GTF2H4,CCNH,POLR2C,TAF11,GTF2B,SSRP1,ERCC3,CDK9
R-HSA-391251	Protein folding	0.0375588412609802	-3.2818464754646	105	42	0.0130071229482812	3229	10285	2784,2793,1460,2781,6905,9628,5202,7846,2771,5082,60,2775,10576,2790,2787,2791,6468,2773,2785,10694,51764,10471,10376,5203,26224,10574,406974,54331,55294,10383,55970,6950,8841,55135,1457,5201,59345,2788,22948,5204,7157,2782	GNB3,GNGT2,CSNK2B,GNAZ,TBCE,RGS6,PFDN2,TUBA1A,GNAI2,PDCL,ACTB,GNAO1,CCT2,GNG10,GNG5,GNG11,FBXW4,GNAI3,GNG3,CCT8,GNG13,PFDN6,TUBA1B,PFDN4,FBXL3,CCT7,MIR197,GNG2,FBXW7,TUBB4B,GNG12,TCP1,HDAC3,WRAP53,CSNK2A1,PFDN1,GNB4,GNG7,CCT5,PFDN5,TP53,GNB1
R-HSA-5656169	Termination of translesion DNA synthesis	0.0401075321587839	-3.21619112792464	34	16	0.00495509445648808	3229	10285	6233,5425,7311,5984,6118,7314,54107,5111,9636,56655,9768,5983,6119,5982,5985,57804	RPS27A,POLD2,UBA52,RFC4,RPA2,UBB,POLE3,PCNA,ISG15,POLE4,PCLAF,RFC3,RPA3,RFC2,RFC5,POLD4
R-HSA-5654727	Negative regulation of FGFR2 signaling	0.0401075321587839	-3.21619112792464	34	16	0.00495509445648808	3229	10285	867,5518,7314,6233,27006,7311,5781,8074,5516,8822,2255,2246,2252,6714,8823,2248	CBL,PPP2R1A,UBB,RPS27A,FGF22,UBA52,PTPN11,FGF23,PPP2CB,FGF17,FGF10,FGF1,FGF7,SRC,FGF16,FGF3
R-HSA-209560	NF-kB is activated and signals survival	0.0409096964458595	-3.19638816711579	14	8	0.00247754722824404	3229	10285	3551,4790,7189,7311,6233,7314,8878,4792	IKBKB,NFKB1,TRAF6,UBA52,RPS27A,UBB,SQSTM1,NFKBIA
R-HSA-1679131	Trafficking and processing of endosomal TLR	0.0409096964458595	-3.19638816711579	14	8	0.00247754722824404	3229	10285	7098,1513,1508,51311,54106,7184,10695,51284	TLR3,CTSK,CTSB,TLR8,TLR9,HSP90B1,CNPY3,TLR7
R-HSA-69166	Removal of the Flap Intermediate	0.0409096964458595	-3.19638816711579	14	8	0.00247754722824404	3229	10285	5425,6118,5558,23649,5111,2237,6119,57804	POLD2,RPA2,PRIM2,POLA2,PCNA,FEN1,RPA3,POLD4
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.0423730621643172	-3.16124244496278	29	14	0.00433570764942707	3229	10285	1660,4790,177,7335,10454,6285,4792,4615,7334,4793,3551,23118,3146,7189	DHX9,NFKB1,AGER,UBE2V1,TAB1,S100B,NFKBIA,MYD88,UBE2N,NFKBIB,IKBKB,TAB2,HMGB1,TRAF6
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.0439226484963347	-3.12532518085914	19	10	0.00309693403530505	3229	10285	2033,891,7029,1647,1874,983,2810,581,5111,7157	EP300,CCNB1,TFDP2,GADD45A,E2F4,CDK1,SFN,BAX,PCNA,TP53
R-HSA-6811438	Intra-Golgi traffic	0.0446549343843932	-3.10879046523729	45	20	0.0061938680706101	3229	10285	9342,9267,8774,8675,9950,9382,9266,6811,10228,83452,51272,10652,9527,375,9827,27128,10905,9570,8775,27314	SNAP29,CYTH1,NAPG,STX16,GOLGA5,COG1,CYTH2,STX5,STX6,RAB33B,BET1L,YKT6,GOSR1,ARF1,RGP1,CYTH4,MAN1A2,GOSR2,NAPA,RAB30
R-HSA-73886	Chromosome Maintenance	0.0448408669750177	-3.10463534610743	109	43	0.0133168163518117	3229	10285	8334,255626,54107,8331,7015,5111,5984,5558,8345,5985,6119,79019,55651,91687,5983,85236,8335,55135,1736,401541,55766,10856,2237,8348,3014,387103,6118,8342,8970,5928,5425,11339,8467,5931,94239,474382,57804,3013,5982,23649,8607,3015,56655	H2AC6,H2BC1,POLE3,H2AC14,TERT,PCNA,RFC4,PRIM2,H2BC9,RFC5,RPA3,CENPM,NHP2,CENPL,RFC3,H2BC12,H2AC4,WRAP53,DKC1,CENPP,H2AJ,RUVBL2,FEN1,H2BC17,H2AX,CENPW,RPA2,H2BC14,H2BC11,RBBP4,POLD2,OIP5,SMARCA5,RBBP7,H2AZ2,H2AB1,POLD4,H2AC7,RFC2,POLA2,RUVBL1,H2AZ1,POLE4
R-HSA-399721	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	0.0478224619839402	-3.04025983387865	32	15	0.00464540105295757	3229	10285	818,5579,2890,9463,4193,7102,2891,4646,1175,10368,5578,1739,160,1173,1742	CAMK2G,PRKCB,GRIA1,PICK1,MDM2,TSPAN7,GRIA2,MYO6,AP2S1,CACNG3,PRKCA,DLG1,AP2A1,AP2M1,DLG4
R-HSA-70263	Gluconeogenesis	0.0478224619839402	-3.04025983387865	32	15	0.00464540105295757	3229	10285	2023,5091,6576,2026,5223,8789,2203,1468,2597,5230,8604,8402,4190,5106,5567	ENO1,PC,SLC25A1,ENO2,PGAM1,FBP2,FBP1,SLC25A10,GAPDH,PGK1,SLC25A12,SLC25A11,MDH1,PCK2,PRKACB
R-HSA-2559585	Oncogene Induced Senescence	0.0478224619839402	-3.04025983387865	32	15	0.00464540105295757	3229	10285	26523,4193,4343,6667,3397,1032,1019,7157,1031,7311,6233,7314,7029,57690,1021	AGO1,MDM2,MOV10,SP1,ID1,CDKN2D,CDK4,TP53,CDKN2C,UBA52,RPS27A,UBB,TFDP2,TNRC6C,CDK6
R-HSA-399719	Trafficking of AMPA receptors	0.0478224619839402	-3.04025983387865	32	15	0.00464540105295757	3229	10285	1742,160,1173,1739,5578,10368,1175,4646,2891,9463,7102,4193,2890,5579,818	DLG4,AP2A1,AP2M1,DLG1,PRKCA,CACNG3,AP2S1,MYO6,GRIA2,PICK1,TSPAN7,MDM2,GRIA1,PRKCB,CAMK2G
R-HSA-977444	GABA B receptor activation	0.0487145653965124	-3.02177720949303	40	18	0.00557448126354909	3229	10285	2785,2773,3759,2550,2782,108,2788,2790,3760,2787,54331,3766,55970,2771,109,2793,2784,406974	GNG3,GNAI3,KCNJ2,GABBR1,GNB1,ADCY2,GNG7,GNG10,KCNJ3,GNG5,GNG2,KCNJ10,GNG12,GNAI2,ADCY3,GNGT2,GNB3,MIR197
R-HSA-991365	Activation of GABAB receptors	0.0487145653965124	-3.02177720949303	40	18	0.00557448126354909	3229	10285	2550,2782,108,3759,2773,2785,2787,3760,2790,2788,2771,55970,109,3766,54331,406974,2793,2784	GABBR1,GNB1,ADCY2,KCNJ2,GNAI3,GNG3,GNG5,KCNJ3,GNG10,GNG7,GNAI2,GNG12,ADCY3,KCNJ10,GNG2,MIR197,GNGT2,GNB3
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.0488550837721365	-3.01889683687772	12	7	0.00216785382471353	3229	10285	2810,983,7532,7533,7534,891,7529	SFN,CDK1,YWHAG,YWHAH,YWHAZ,CCNB1,YWHAB
R-HSA-8866427	VLDLR internalisation and degradation	0.0488550837721365	-3.01889683687772	12	7	0.00216785382471353	3229	10285	1175,29116,7436,7376,255738,160,1173	AP2S1,MYLIP,VLDLR,NR1H2,PCSK9,AP2A1,AP2M1
R-HSA-203615	eNOS activation	0.0488550837721365	-3.01889683687772	12	7	0.00216785382471353	3229	10285	23564,114757,10434,857,3320,23576,207	DDAH2,CYGB,LYPLA1,CAV1,HSP90AA1,DDAH1,AKT1
R-HSA-417957	P2Y receptors	0.0488550837721365	-3.01889683687772	12	7	0.00216785382471353	3229	10285	5028,2840,5032,5030,64805,10161,27334	P2RY1,GPR17,P2RY11,P2RY4,P2RY12,LPAR6,P2RY10
R-HSA-1852241	Organelle biogenesis and maintenance	0.0521609745802733	-2.95342067710054	340	121	0.0374729018271911	3229	10285	6742,64979,5518,124995,64965,4208,64963,6604,84340,11336,51021,8766,65993,983,6182,7284,84100,54585,55081,83657,29074,92259,123016,11258,54460,7283,129880,79590,1385,64975,22948,8655,740,6150,200186,6950,2553,2847,51649,51650,5465,84747,8195,57728,10694,22919,29093,118487,51098,51668,85476,51023,65005,7532,55168,116540,23322,65003,5147,78988,51373,64981,55763,56623,51106,149371,122704,79598,55770,1069,5048,64432,51258,60488,51081,1454,6102,56652,3797,63875,10576,10640,506,132320,1781,4751,80321,64976,27077,54820,9553,54534,2551,28957,55052,57129,28973,10383,5564,619553,8841,10121,95681,64949,3320,10013,54948,28998,203068,64792,54998,79969,55142,9371,1387,5571,378,7846,26160,8636,80776	SSBP1,MRPL36,PPP2R1A,MRPL10,MRPS9,MEF2C,MRPS11,SMARCD3,GFM2,EXOC3,MRPS16,RAB11A,MRPS34,CDK1,MRPL12,TUFM,ARL6,LZTFL1,IFT57,DYNLRB2,MRPL18,KGD4,TTC8,DCTN3,MRPS21,TUBG1,BBS5,MRPL24,CREB1,MRPL41,CCT5,DYNLL1,MRPL49,MRPL23,CRTC2,TCP1,GABPB1,MCHR1,MRPS23,MRPS33,PPARA,UNC119B,MKKS,WDR19,CCT8,MAPRE1,MRPL22,CHCHD1,IFT52,IFT25,GFM1,MRPS18C,MRPL9,YWHAG,MRPS18A,MRPL53,RPGRIP1L,MRPL11,PDE6D,MRPL57,MRPS17,MRPL34,EXOC1,INPP5E,TFB1M,EXOC8,MRPL52,CEP97,EXOC2,CETN2,PAFAH1B1,MRPS25,MRPL51,MRPS35,MRPS7,CSNK1E,RP2,TWNK,KIF3C,MRPL17,CCT2,EXOC5,ATP5F1B,SCLT1,DYNC1I2,NEK2,CEP70,MRPL40,B9D1,NDE1,MRPL33,MRPL50,GABPA,MRPS28,MRPL20,MRPL47,MRPS18B,TUBB4B,PRKAB1,MIR484,HDAC3,ACTR1A,CEP41,MRPS26,HSP90AA1,HDAC6,MRPL16,MRPL13,TUBB,IFT22,AURKAIP1,ATAT1,HAUS2,KIF3B,CREBBP,PRKAG1,ARF4,TUBA1A,IFT172,SSNA1,B9D2
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	0.052647569264515	-2.9441352092834	43	19	0.00588417466707959	3229	10285	51764,361,108,5567,2782,2785,2791,2787,2790,2788,59345,360,8766,55970,109,359,54331,2784,2793	GNG13,AQP4,ADCY2,PRKACB,GNB1,GNG3,GNG11,GNG5,GNG10,GNG7,GNB4,AQP3,RAB11A,GNG12,ADCY3,AQP2,GNG2,GNB3,GNGT2
R-HSA-1236394	Signaling by ERBB4	0.052647569264515	-2.9441352092834	43	19	0.00588417466707959	3229	10285	3845,3265,11059,7314,51107,6776,5290,7311,6233,5664,5295,1839,6464,5241,23118,55851,6387,6285,23385	KRAS,HRAS,WWP1,UBB,APH1A,STAT5A,PIK3CA,UBA52,RPS27A,PSEN2,PIK3R1,HBEGF,SHC1,PGR,TAB2,PSENEN,CXCL12,S100B,NCSTN
R-HSA-5621575	CD209 (DC-SIGN) signaling	0.0528211703987731	-2.94084321410849	22	11	0.00340662743883555	3229	10285	3384,5567,30835,2033,1387,5894,3265,3385,4790,3845,5062	ICAM2,PRKACB,CD209,EP300,CREBBP,RAF1,HRAS,ICAM3,NFKB1,KRAS,PAK2
R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.0528211703987731	-2.94084321410849	22	11	0.00340662743883555	3229	10285	5290,941,207,10000,940,9020,5296,5295,208,942,8503	PIK3CA,CD80,AKT1,AKT3,CD28,MAP3K14,PIK3R2,PIK3R1,AKT2,CD86,PIK3R3
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	0.0529500646968948	-2.93840598508665	17	9	0.00278724063177454	3229	10285	5579,1175,2891,160,7102,1173,9463,5578,2890	PRKCB,AP2S1,GRIA2,AP2A1,TSPAN7,AP2M1,PICK1,PRKCA,GRIA1
R-HSA-193639	p75NTR signals via NF-kB	0.0529500646968948	-2.93840598508665	17	9	0.00278724063177454	3229	10285	8878,4615,4792,7314,6233,7311,7189,4790,3551	SQSTM1,MYD88,NFKBIA,UBB,RPS27A,UBA52,TRAF6,NFKB1,IKBKB
R-HSA-1483255	PI Metabolism	0.0537366001557357	-2.92366094248281	79	32	0.00991018891297615	3229	10285	5295,8503,51763,5296,9896,375,3636,51573,4534,55697,79153,5728,5867,79837,5290,5294,3631,8394,126282,8898,90809,23760,388121,22908,56623,51552,9107,5868,25816,79626,4952,84725	PIK3R1,PIK3R3,INPP5K,PIK3R2,FIG4,ARF1,INPPL1,GDE1,MTM1,VAC14,GDPD3,PTEN,RAB4A,PIP4K2C,PIK3CA,PIK3CG,INPP4A,PIP5K1A,TNFAIP8L1,MTMR2,PIP4P1,PITPNB,TNFAIP8L3,SACM1L,INPP5E,RAB14,MTMR6,RAB5A,TNFAIP8,TNFAIP8L2,OCRL,PLEKHA8
R-HSA-381042	PERK regulates gene expression	0.0571008634361206	-2.86293604096128	30	14	0.00433570764942707	3229	10285	51013,51010,468,54512,4800,6347,467,4801,3309,3576,1965,167227,11340,1649	EXOSC1,EXOSC3,ATF4,EXOSC4,NFYA,CCL2,ATF3,NFYB,HSPA5,CXCL8,EIF2S1,DCP2,EXOSC8,DDIT3
R-HSA-5689901	Metalloprotease DUBs	0.0576683556834771	-2.85304668427254	38	17	0.00526478786001858	3229	10285	7311,6233,7314,92815,10213,8329,57559,8331,8334,221613,672,8335,2033,10617,3013,114548,29086	UBA52,RPS27A,UBB,H2AC25,PSMD14,H2AC13,STAMBPL1,H2AC14,H2AC6,H2AC1,BRCA1,H2AC4,EP300,STAMBP,H2AC7,NLRP3,BABAM1
R-HSA-3215018	Processing and activation of SUMO	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	7341,6613,7329,205564,6612,25950	SUMO1,SUMO2,UBE2I,SENP5,SUMO3,RWDD3
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	7314,7311,10454,6233,7189,23118	UBB,UBA52,TAB1,RPS27A,TRAF6,TAB2
R-HSA-727802	Transport of nucleotide sugars	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	10559,51000,7355,84912,55343,23169	SLC35A1,SLC35B3,SLC35A2,SLC35B4,SLC35C1,SLC35D1
R-HSA-430116	GP1b-IX-V activation signalling	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	7450,5894,7534,2815,5295,6714	VWF,RAF1,YWHAZ,GP9,PIK3R1,SRC
R-HSA-193692	Regulated proteolysis of p75NTR	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	4790,5664,7189,23385,55851,51107	NFKB1,PSEN2,TRAF6,NCSTN,PSENEN,APH1A
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	57804,2237,6119,5111,6118,5425	POLD4,FEN1,RPA3,PCNA,RPA2,POLD2
R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	7157,90809,3622,5608,2033,79837	TP53,PIP4P1,ING2,MAP2K6,EP300,PIP4K2C
R-HSA-168799	Neurotoxicity of clostridium toxins	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	6843,6844,6804,127833,9899,6616	VAMP1,VAMP2,STX1A,SYT2,SV2B,SNAP25
R-HSA-390450	Folding of actin by CCT/TriC	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	22948,10576,10574,60,6950,10694	CCT5,CCT2,CCT7,ACTB,TCP1,CCT8
R-HSA-2562578	TRIF-mediated programmed cell death	0.0583177559482435	-2.84184867027575	10	6	0.00185816042118303	3229	10285	148022,353376,23643,7098,929,7099	TICAM1,TICAM2,LY96,TLR3,CD14,TLR4
R-HSA-5654700	FRS-mediated FGFR2 signaling	0.0609317052992425	-2.7980016272709	25	12	0.00371632084236606	3229	10285	10817,2248,8823,8822,2246,2255,2252,5781,3845,8074,3265,27006	FRS3,FGF3,FGF16,FGF17,FGF1,FGF10,FGF7,PTPN11,KRAS,FGF23,HRAS,FGF22
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.0609317052992425	-2.7980016272709	25	12	0.00371632084236606	3229	10285	2963,5436,5432,6827,5435,5433,5438,5441,2962,5431,22916,6829	GTF2F2,POLR2G,POLR2C,SUPT4H1,POLR2F,POLR2D,POLR2I,POLR2L,GTF2F1,POLR2B,NCBP2,SUPT5H
R-HSA-5654708	Downstream signaling of activated FGFR3	0.0609317052992425	-2.7980016272709	25	12	0.00371632084236606	3229	10285	5295,10817,8823,6464,8822,2246,5781,3845,8074,3265,2549,5290	PIK3R1,FRS3,FGF16,SHC1,FGF17,FGF1,PTPN11,KRAS,FGF23,HRAS,GAB1,PIK3CA
R-HSA-5357905	Regulation of TNFR1 signaling	0.062940869466103	-2.76555957323565	33	15	0.00464540105295757	3229	10285	7311,6233,7314,7124,25999,7185,8887,7186,9099,56957,7128,3551,90268,329,10616	UBA52,RPS27A,UBB,TNF,CLIP3,TRAF1,TAX1BP1,TRAF2,USP2,OTUD7B,TNFAIP3,IKBKB,OTULIN,BIRC2,RBCK1
R-HSA-5654726	Negative regulation of FGFR1 signaling	0.062940869466103	-2.76555957323565	33	15	0.00464540105295757	3229	10285	6714,2248,2255,2246,8822,8074,2260,5781,5516,7314,867,5518,27006,7311,6233	SRC,FGF3,FGF10,FGF1,FGF17,FGF23,FGFR1,PTPN11,PPP2CB,UBB,CBL,PPP2R1A,FGF22,UBA52,RPS27A
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	0.0637355227538606	-2.75301321479045	20	10	0.00309693403530505	3229	10285	51764,1803,9789,60559,28972,1499,2784,3952,23478,5080	GNG13,DPP4,SPCS2,SPCS3,SPCS1,CTNNB1,GNB3,LEP,SEC11A,PAX6
R-HSA-8876384	Listeria monocytogenes entry into host cells	0.0637355227538606	-2.75301321479045	20	10	0.00309693403530505	3229	10285	1499,4233,1500,6714,79872,6233,7311,867,9146,7314	CTNNB1,MET,CTNND1,SRC,CBLL1,RPS27A,UBA52,CBL,HGS,UBB
R-HSA-190241	FGFR2 ligand binding and activation	0.0637355227538606	-2.75301321479045	20	10	0.00309693403530505	3229	10285	8822,2246,2255,2252,27006,83888,8074,8823,2248,9982	FGF17,FGF1,FGF10,FGF7,FGF22,FGFBP2,FGF23,FGF16,FGF3,FGFBP1
R-HSA-3322077	Glycogen synthesis	0.0640469183830389	-2.74813936447383	15	8	0.00247754722824404	3229	10285	5507,6233,7311,7360,2997,7314,2632,5236	PPP1R3C,RPS27A,UBA52,UGP2,GYS1,UBB,GBE1,PGM1
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	0.0640469183830389	-2.74813936447383	15	8	0.00247754722824404	3229	10285	983,5579,891,4001,4000,23592,5578,7112	CDK1,PRKCB,CCNB1,LMNB1,LMNA,LEMD3,PRKCA,TMPO
R-HSA-69183	Processive synthesis on the lagging strand	0.0640469183830389	-2.74813936447383	15	8	0.00247754722824404	3229	10285	23649,5558,6118,5425,57804,2237,6119,5111	POLA2,PRIM2,RPA2,POLD2,POLD4,FEN1,RPA3,PCNA
R-HSA-3371568	Attenuation phase	0.0640469183830389	-2.74813936447383	15	8	0.00247754722824404	3229	10285	10728,3281,3326,3320,2033,1387,3312,2288	PTGES3,HSBP1,HSP90AB1,HSP90AA1,EP300,CREBBP,HSPA8,FKBP4
R-HSA-975577	N-Glycan antennae elongation	0.0640469183830389	-2.74813936447383	15	8	0.00247754722824404	3229	10285	11282,9331,8702,2683,6484,11320,6480,8703	MGAT4B,B4GALT6,B4GALT4,B4GALT1,ST3GAL4,MGAT4A,ST6GAL1,B4GALT3
R-HSA-112316	Neuronal System	0.0656127497969167	-2.72398524525659	349	123	0.0380922886342521	3229	10285	8499,2555,1741,785,80331,1312,54207,131096,8224,8573,43,3764,83988,59345,2554,6506,9454,1739,4747,64130,10815,347731,2572,10242,2793,6812,2784,5579,2771,10211,1175,3738,783,6538,127833,1173,2785,27020,55970,6539,7102,54331,3746,6507,89822,2788,26045,5567,5578,3312,22871,81539,7881,6529,1385,56479,109,9463,56659,3754,108,3759,5330,1742,406974,9456,2562,55327,3766,3752,10368,3737,2752,79414,10550,26037,6505,170850,347730,784,818,2891,2791,3265,54407,6532,22839,2773,3779,6844,3778,3767,6531,84694,3745,1141,1139,3760,140679,10052,2782,2550,5894,2911,5864,6616,8541,2566,2890,4193,6804,3756,3787,4646,2787,3751,57555,23236,2790,51764,160,2561,2897	PPFIA2,GABRA2,DLG3,CACNB4,DNAJC5,COMT,KCNK10,KCNH8,SYN3,CASK,ACHE,KCNJ8,NCALD,GNB4,GABRA1,SLC1A2,HOMER3,DLG1,NEFL,LIN7B,CPLX1,LRRTM3,GAD2,KCNMB2,GNGT2,STXBP1,GNB3,PRKCB,GNAI2,FLOT1,AP2S1,KCNA3,CACNB2,SLC6A11,SYT2,AP2M1,GNG3,NPTN,GNG12,SLC6A12,TSPAN7,GNG2,KCNC1,SLC1A3,KCNK17,GNG7,LRRTM2,PRKACB,PRKCA,HSPA8,NLGN1,SLC38A1,KCNAB1,SLC6A1,CREB1,KCNQ5,ADCY3,PICK1,KCNK13,KCNF1,ADCY2,KCNJ2,PLCB2,DLG4,MIR197,HOMER1,GABRB3,LIN7C,KCNJ10,KCND3,CACNG3,KCNA2,GLUL,LRFN3,ARL6IP5,SIPA1L1,SLC1A1,KCNG3,LRRTM1,CACNB3,CAMK2G,GRIA2,GNG11,HRAS,SLC38A2,SLC6A4,DLGAP4,GNAI3,KCNMB1,VAMP2,KCNMA1,KCNJ11,SLC6A3,GJA10,KCNB1,CHRNB2,CHRNA7,KCNJ3,SLC32A1,GJC1,GNB1,GABBR1,RAF1,GRM1,RAB3A,SNAP25,PPFIA3,GABRG2,GRIA1,MDM2,STX1A,KCNH1,KCNS1,MYO6,GNG5,KCND2,NLGN2,PLCB1,GNG10,GNG13,AP2A1,GABRB2,GRIK1
R-HSA-75105	Fatty Acyl-CoA Biosynthesis	0.0661080023483533	-2.71646547518058	55	23	0.00712294828120161	3229	10285	10005,414149,5538,6576,693224,84320,401494,9200,79071,79993,641372,55856,3293,79966,64834,51495,31,9524,83401,201562,6785,2182,55750	ACOT8,ACBD7,PPT1,SLC25A1,MIR639,ACBD6,HACD4,HACD1,ELOVL6,ELOVL7,ACOT6,ACOT13,HSD17B3,SCD5,ELOVL1,HACD3,ACACA,TECR,ELOVL3,HACD2,ELOVL4,ACSL4,AGK
R-HSA-156580	Phase II conjugation	0.0661790306698546	-2.7153916234703	106	41	0.0126974295447507	3229	10285	6818,7358,9446,51504,4258,119391,2950,2938,373156,2729,7360,79799,27430,2948,55748,27284,55347,51000,1312,10,2949,10249,84836,494143,2686,4144,2098,2941,10327,9060,2939,2952,27306,389396,4259,54658,2946,79017,23169,2947,653689	SULT1A3,UGDH,GSTO1,TRMT112,MGST2,GSTO2,GSTP1,GSTA1,GSTK1,GCLC,UGP2,UGT2A3,MAT2B,GSTM4,CNDP2,SULT1B1,ABHD10,SLC35B3,COMT,NAT2,GSTM5,GLYAT,ABHD14B,CHAC2,GGT7,MAT2A,ESD,GSTA4,AKR1A1,PAPSS2,GSTA2,GSTT1,HPGDS,GLYATL3,MGST3,UGT1A1,GSTM2,GGCT,SLC35D1,GSTM3,GSTT2B
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.0665237730367971	-2.71019590592925	69	28	0.00867141529885413	3229	10285	5435,7157,6827,6921,5436,2963,9656,2966,404672,5441,5433,6917,1022,672,4331,6829,5431,902,5432,3725,2968,2962,5438,51755,1025,2353,2071,6749	POLR2F,TP53,SUPT4H1,ELOC,POLR2G,GTF2F2,MDC1,GTF2H2,GTF2H5,POLR2L,POLR2D,TCEA1,CDK7,BRCA1,MNAT1,SUPT5H,POLR2B,CCNH,POLR2C,JUN,GTF2H4,GTF2F1,POLR2I,CDK12,CDK9,FOS,ERCC3,SSRP1
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	0.0682863114067478	-2.68404595113395	28	13	0.00402601424589656	3229	10285	7251,27183,51534,27243,51510,7314,6233,7311,51160,9525,92421,25978,9146	TSG101,VPS4A,VTA1,CHMP2A,CHMP5,UBB,RPS27A,UBA52,VPS28,VPS4B,CHMP4C,CHMP2B,HGS
R-HSA-434316	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	0.0694401897652547	-2.66728947583921	8	5	0.00154846701765252	3229	10285	23236,2776,5330,2767,9630	PLCB1,GNAQ,PLCB2,GNA11,GNA14
R-HSA-5358493	Synthesis of diphthamide-EEF2	0.0694401897652547	-2.66728947583921	8	5	0.00154846701765252	3229	10285	1938,120526,285381,51611,89978	EEF2,DNAJC24,DPH3,DPH5,DPH6
R-HSA-400451	Free fatty acids regulate insulin secretion	0.0694401897652547	-2.66728947583921	8	5	0.00154846701765252	3229	10285	5330,2767,9630,2776,23236	PLCB2,GNA11,GNA14,GNAQ,PLCB1
R-HSA-73942	DNA Damage Reversal	0.0694401897652547	-2.66728947583921	8	5	0.00154846701765252	3229	10285	54890,221120,121642,4255,51008	ALKBH5,ALKBH3,ALKBH2,MGMT,ASCC1
R-HSA-72731	Recycling of eIF2:GDP	0.0694401897652547	-2.66728947583921	8	5	0.00154846701765252	3229	10285	8893,8894,8892,1965,8891	EIF2B5,EIF2S2,EIF2B2,EIF2S1,EIF2B3
R-HSA-500792	GPCR ligand binding	0.0704941716420201	-2.65222524432581	453	157	0.0486218643542893	3229	10285	5028,4986,6869,6364,84539,5737,2859,84432,259285,1393,3355,680,4829,283869,387129,154,6363,2919,6863,1230,187,1394,10911,256933,259292,7852,5732,7472,10563,3060,2788,1232,2833,122042,1131,3576,8322,8477,117579,553,55970,1524,54331,6376,6019,7476,4889,9170,10663,7349,1236,8862,2921,27198,4987,5744,2785,8698,1132,7253,2784,2793,50833,259286,5731,6346,6370,2840,59345,54429,3577,1909,79924,2918,148,64805,7976,51738,6870,9283,3627,2847,1812,319100,57007,134,6368,3274,153,2787,2790,51764,3356,1814,56477,2911,2797,7480,1902,6366,4887,10161,6352,5030,50837,2147,5539,5032,10850,2782,50838,2550,113091,155,6373,2831,54886,6750,6375,134864,1133,2791,1235,729230,10268,1233,27334,50865,4886,140,3350,2925,151306,2796,1234,5734,8323,2837,30817,2861,4295,2912,80834,11255,4988,5368,5173,114814,3972,3361,170589,1128,5021,1268,6387,4283,4852	P2RY1,OPRK1,TACR1,CCL20,MCHR2,PTGFR,GPR35,PROK1,TAS2R39,CRHBP,HTR1F,BRS3,NMBR,NPW,NPSR1,ADRB2,CCL19,CXCL1,TAC1,CCR1,APLNR,CRHR1,UTS2,NPB,TAS2R46,CXCR4,PTGER2,WNT2,CXCL13,HCRT,GNG7,CCR3,CXCR3,RXFP2,CHRM3,CXCL8,FZD4,GPR65,RLN3,AVPR1B,GNG12,CX3CR1,GNG2,CX3CL1,RLN2,WNT7A,NPY5R,LPAR2,CXCR6,UCN,CCR7,APLN,CXCL3,HCAR1,OPRL1,PTHLH,GNG3,S1PR4,CHRM4,TSHR,GNB3,GNGT2,TAS2R16,TAS2R40,PTGER1,CCL1,CCL25,GPR17,GNB4,TAS2R5,CXCR1,EDNRA,ADM2,GRM8,ADRA1A,P2RY12,FZD3,GHRL,TACR3,GPR37L1,CXCL10,MCHR1,DRD1,TAAR6,ACKR3,ADORA1,CCL23,HRH2,ADRB1,GNG5,GNG10,GNG13,HTR2A,DRD3,CCL28,GRM1,GNRH2,WNT10B,LPAR1,CCL21,NPY2R,LPAR6,CCL5,P2RY4,TAS2R7,F2,PPY,P2RY11,CCL27,GNB1,TAS2R13,GABBR1,PTH2,ADRB3,CXCL11,NPBWR1,PLPPR1,SST,XCL1,TAAR1,CHRM5,GNG11,CCR6,CCR2,RAMP3,CCR4,P2RY10,HEBP1,NPY1R,ADORA3,HTR1A,GRPR,GPBAR1,GNRH1,CCR5,PTGER4,FZD6,UTS2R,ADGRE2,GPR37,MLN,GRM2,TAS1R2,HRH3,OPRM1,PNOC,PDYN,GNRHR2,LHB,HTR5A,GPHA2,CHRM1,OXTR,CNR1,CXCL12,CXCL9,NPY
R-HSA-4086398	Ca2+ pathway	0.0716412805716603	-2.63608382685641	61	25	0.00774233508826262	3229	10285	5578,2782,7976,57690,5530,1499,59345,2788,55970,4343,54331,26523,8322,51764,5330,2785,2787,2791,23236,2775,2790,5145,8323,2784,2793	PRKCA,GNB1,FZD3,TNRC6C,PPP3CA,CTNNB1,GNB4,GNG7,GNG12,MOV10,GNG2,AGO1,FZD4,GNG13,PLCB2,GNG3,GNG5,GNG11,PLCB1,GNAO1,GNG10,PDE6A,FZD6,GNB3,GNGT2
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	0.0732418208907275	-2.61398869751427	39	17	0.00526478786001858	3229	10285	120526,2677,83475,51611,1725,5045,79672,285381,5627,1938,89978,2159,2158,2147,56648,2155,632	DNAJC24,GGCX,DOHH,DPH5,DHPS,FURIN,FN3KRP,DPH3,PROS1,EEF2,DPH6,F10,F9,F2,EIF5A2,F7,BGLAP
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.0732418208907275	-2.61398869751427	39	17	0.00526478786001858	3229	10285	1069,8607,60,10987,86,10038,125476,29844,50813,7314,9318,6233,5887,64708,51138,7311,283899	CETN2,RUVBL1,ACTB,COPS5,ACTL6A,PARP2,INO80C,TFPT,COPS7A,UBB,COPS2,RPS27A,RAD23B,COPS7B,COPS4,UBA52,INO80E
R-HSA-5654699	SHC-mediated cascade:FGFR2	0.0733158064448207	-2.61297905288883	23	11	0.00340662743883555	3229	10285	27006,3265,3845,8074,2252,2255,2246,8822,2248,6464,8823	FGF22,HRAS,KRAS,FGF23,FGF7,FGF10,FGF1,FGF17,FGF3,SHC1,FGF16
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	0.0733158064448207	-2.61297905288883	23	11	0.00340662743883555	3229	10285	3725,356,4001,7001,4000,1020,824,5052,8851,823,6648	JUN,FASLG,LMNB1,PRDX2,LMNA,CDK5,CAPN2,PRDX1,CDK5R1,CAPN1,SOD2
R-HSA-8863678	Neurodegenerative Diseases	0.0733158064448207	-2.61297905288883	23	11	0.00340662743883555	3229	10285	356,5052,3725,1020,824,6648,4000,823,7001,4001,8851	FASLG,PRDX1,JUN,CDK5,CAPN2,SOD2,LMNA,CAPN1,PRDX2,LMNB1,CDK5R1
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.0733158064448207	-2.61297905288883	23	11	0.00340662743883555	3229	10285	2248,10817,8822,2255,2246,3265,8074,2260,3845,5781,27006	FGF3,FRS3,FGF17,FGF10,FGF1,HRAS,FGF23,FGFR1,KRAS,PTPN11,FGF22
R-HSA-73887	Death Receptor Signalling	0.0735604742770381	-2.60964743178124	50	21	0.0065035614741406	3229	10285	7314,25999,6610,7124,7311,6233,7186,356,7185,355,8887,7128,9099,10454,56957,10616,3551,90268,8743,23118,329	UBB,CLIP3,SMPD2,TNF,UBA52,RPS27A,TRAF2,FASLG,TRAF1,FAS,TAX1BP1,TNFAIP3,USP2,TAB1,OTUD7B,RBCK1,IKBKB,OTULIN,TNFSF10,TAB2,BIRC2
R-HSA-73893	DNA Damage Bypass	0.0735604742770381	-2.60964743178124	50	21	0.0065035614741406	3229	10285	5425,6233,7311,5984,7314,6118,54107,5111,10459,9636,56655,5983,9768,7353,6119,5982,7320,25898,5985,51514,57804	POLD2,RPS27A,UBA52,RFC4,UBB,RPA2,POLE3,PCNA,MAD2L2,ISG15,POLE4,RFC3,PCLAF,UFD1,RPA3,RFC2,UBE2B,RCHY1,RFC5,DTL,POLD4
R-HSA-1632852	Macroautophagy	0.0765030731616695	-2.57042436690855	67	27	0.00836172189532363	3229	10285	5571,11345,11152,55004,11337,64422,8649,84557,6009,9821,10670,8678,28956,55054,5564,25978,115201,92421,84938,10533,27243,81631,60673,10325,79065,8655,23710	PRKAG1,GABARAPL2,WDR45,LAMTOR1,GABARAP,ATG3,LAMTOR3,MAP1LC3A,RHEB,RB1CC1,RRAGA,BECN1,LAMTOR2,ATG16L1,PRKAB1,CHMP2B,ATG4A,CHMP4C,ATG4C,ATG7,CHMP2A,MAP1LC3B,ATG101,RRAGB,ATG9A,DYNLL1,GABARAPL1
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.0767626972786411	-2.56703646934274	110	42	0.0130071229482812	3229	10285	246184,8345,7311,6233,3576,7314,890,51529,8331,255626,1031,8334,51343,85236,8335,29945,7321,29882,25906,8697,3552,8342,8970,1021,3014,4790,8348,55766,3725,2353,3015,3569,119504,1027,1032,1019,3013,8881,1026,8350,94239,474382	CDC26,H2BC9,UBA52,RPS27A,CXCL8,UBB,CCNA2,ANAPC11,H2AC14,H2BC1,CDKN2C,H2AC6,FZR1,H2BC12,H2AC4,ANAPC4,UBE2D1,ANAPC2,ANAPC15,CDC23,IL1A,H2BC14,H2BC11,CDK6,H2AX,NFKB1,H2BC17,H2AJ,JUN,FOS,H2AZ1,IL6,ANAPC16,CDKN1B,CDKN2D,CDK4,H2AC7,CDC16,CDKN1A,H3C1,H2AZ2,H2AB1
R-HSA-8856688	Golgi-to-ER retrograde transport	0.0767626972786411	-2.56703646934274	110	42	0.0130071229482812	3229	10285	10749,55850,8655,64837,51014,5050,11316,23299,2589,10671,53407,5870,2590,60561,10945,22931,5048,23423,9554,54732,8774,29127,11258,5049,51226,6836,3796,372,26286,3797,51164,375,55738,5861,51560,81876,1780,8775,378,1781,9371,11014	KIF1C,USE1,DYNLL1,KLC2,TMED7,PAFAH1B3,COPE,BICD2,GALNT1,DCTN6,STX18,RAB6A,GALNT2,RINT1,KDELR1,RAB18,PAFAH1B1,TMED3,SEC22B,TMED9,NAPG,RACGAP1,DCTN3,PAFAH1B2,COPZ2,SURF4,KIF2A,ARCN1,ARFGAP3,KIF3C,DCTN4,ARF1,ARFGAP1,RAB1A,RAB6B,RAB1B,DYNC1I1,NAPA,ARF4,DYNC1I2,KIF3B,KDELR2
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	0.0771686385480156	-2.56176214091245	18	9	0.00278724063177454	3229	10285	4050,8742,4049,4055,9020,329,958,959,7186	LTB,TNFSF12,LTA,LTBR,MAP3K14,BIRC2,CD40,CD40LG,TRAF2
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.0771686385480156	-2.56176214091245	18	9	0.00278724063177454	3229	10285	6804,10815,6844,5864,6616,8499,8224,6812,8541	STX1A,CPLX1,VAMP2,RAB3A,SNAP25,PPFIA2,SYN3,STXBP1,PPFIA3
R-HSA-5658623	FGFRL1 modulation of FGFR1 signaling	0.0777877855994289	-2.55377085755983	13	7	0.00216785382471353	3229	10285	2248,8074,27006,200734,161742,2255,8822	FGF3,FGF23,FGF22,SPRED2,SPRED1,FGF10,FGF17
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	0.0777877855994289	-2.55377085755983	13	7	0.00216785382471353	3229	10285	7112,23592,8815,4000,5518,4001,7443	TMPO,LEMD3,BANF1,LMNA,PPP2R1A,LMNB1,VRK1
R-HSA-2995410	Nuclear Envelope Reassembly	0.0777877855994289	-2.55377085755983	13	7	0.00216785382471353	3229	10285	8815,4000,23592,7112,7443,4001,5518	BANF1,LMNA,LEMD3,TMPO,VRK1,LMNB1,PPP2R1A
R-HSA-175474	Assembly Of The HIV Virion	0.0777877855994289	-2.55377085755983	13	7	0.00216785382471353	3229	10285	7251,51160,5478,7314,5045,6233,7311	TSG101,VPS28,PPIA,UBB,FURIN,RPS27A,UBA52
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.0777877855994289	-2.55377085755983	13	7	0.00216785382471353	3229	10285	4790,3665,3146,177,4615,6285,1660	NFKB1,IRF7,HMGB1,AGER,MYD88,S100B,DHX9
R-HSA-977443	GABA receptor activation	0.0799206052327983	-2.52672157168755	56	23	0.00712294828120161	3229	10285	2550,2782,2554,3760,2788,55970,3766,54331,2555,406974,2562,108,3759,2785,2773,2561,2787,2790,2771,109,2566,2793,2784	GABBR1,GNB1,GABRA1,KCNJ3,GNG7,GNG12,KCNJ10,GNG2,GABRA2,MIR197,GABRB3,ADCY2,KCNJ2,GNG3,GNAI3,GABRB2,GNG5,GNG10,GNAI2,ADCY3,GABRG2,GNGT2,GNB3
R-HSA-5694530	Cargo concentration in the ER	0.0809671883936746	-2.51371128793697	34	15	0.00464540105295757	3229	10285	5265,6811,1075,966,51128,3998,100313843,9570,2890,10113,2348,9554,4253,10175,10484	SERPINA1,STX5,CTSC,CD59,SAR1B,LMAN1,MIR711,GOSR2,GRIA1,PREB,FOLR1,SEC22B,MIA2,CNIH1,SEC23A
R-HSA-2029485	Role of phospholipids in phagocytosis	0.0818077991347035	-2.50338269597335	26	12	0.00371632084236606	3229	10285	6850,23646,5290,919,2212,2209,196051,5296,917,5295,5581,10768	SYK,PLD3,PIK3CA,CD247,FCGR2A,FCGR1A,PLPP4,PIK3R2,CD3G,PIK3R1,PRKCE,AHCYL1
R-HSA-8851907	MET activates PI3K/AKT signaling	0.0820410926050045	-2.50053502791193	6	4	0.00123877361412202	3229	10285	5295,5290,4233,2549	PIK3R1,PIK3CA,MET,GAB1
R-HSA-3065679	SUMO is proteolytically processed	0.0820410926050045	-2.50053502791193	6	4	0.00123877361412202	3229	10285	205564,6612,6613,7341	SENP5,SUMO3,SUMO2,SUMO1
R-HSA-446199	Synthesis of Dolichyl-phosphate	0.0820410926050045	-2.50053502791193	6	4	0.00123877361412202	3229	10285	79644,4597,22845,116150	SRD5A3,MVD,DOLK,NUS1
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.0820410926050045	-2.50053502791193	6	4	0.00123877361412202	3229	10285	2033,1387,3661,1499	EP300,CREBBP,IRF3,CTNNB1
R-HSA-176417	Phosphorylation of Emi1	0.0820410926050045	-2.50053502791193	6	4	0.00123877361412202	3229	10285	891,983,991,51343	CCNB1,CDK1,CDC20,FZR1
R-HSA-6787639	GDP-fucose biosynthesis	0.0820410926050045	-2.50053502791193	6	4	0.00123877361412202	3229	10285	2762,8790,7264,55343	GMDS,FPGT,GFUS,SLC35C1
R-HSA-8856828	Clathrin-mediated endocytosis	0.0839774236964719	-2.47720728178094	137	51	0.0157943635800557	3229	10285	115548,6845,10987,920,1856,55738,8976,4738,1080,10094,127833,5878,1175,50813,6844,1173,25977,7018,9146,29988,10109,5868,3949,29763,51138,6233,154,382,917,7037,112574,10097,6869,1785,160,2017,64708,84251,27348,8322,55707,9892,9341,8301,9318,7314,4952,867,7311,3312,8673	FCHO2,VAMP7,COPS5,CD4,DVL2,ARFGAP1,WASL,NEDD8,CFTR,ARPC3,SYT2,RAB5C,AP2S1,COPS7A,VAMP2,AP2M1,NECAP1,TF,HGS,SLC2A8,ARPC2,RAB5A,LDLR,PACSIN3,COPS4,RPS27A,ADRB2,ARF6,CD3G,TFRC,SNX18,ACTR2,TACR1,DNM2,AP2A1,CTTN,COPS7B,SGIP1,TOR1B,FZD4,NECAP2,SNAP91,VAMP3,PICALM,COPS2,UBB,OCRL,CBL,UBA52,HSPA8,VAMP8
R-HSA-109704	PI3K Cascade	0.0845397695322287	-2.47053320998598	79	31	0.00960049550944565	3229	10285	6794,10325,27006,5781,2255,8822,5564,2248,1977,54106,10670,207,5290,6009,2549,28956,55437,1975,2260,8074,208,2252,7529,55004,5571,2246,51719,5296,8823,8649,5295	STK11,RRAGB,FGF22,PTPN11,FGF10,FGF17,PRKAB1,FGF3,EIF4E,TLR9,RRAGA,AKT1,PIK3CA,RHEB,GAB1,LAMTOR2,STRADB,EIF4B,FGFR1,FGF23,AKT2,FGF7,YWHAB,LAMTOR1,PRKAG1,FGF1,CAB39,PIK3R2,FGF16,LAMTOR3,PIK3R1
R-HSA-6790901	rRNA modification in the nucleus and cytosol	0.085421567679538	-2.460156661132	62	25	0.00774233508826262	3229	10285	115939,55623,10199,51077,6203,6187,92856,10436,27341,6201,1736,55813,79050,27042,55651,11103,55272,6208,84135,114049,10885,51602,5822,51504,10171	TSR3,THUMPD1,MPHOSPH10,FCF1,RPS9,RPS2,IMP4,EMG1,RRP7A,RPS7,DKC1,UTP6,NOC4L,UTP25,NHP2,KRR1,IMP3,RPS14,UTP15,BUD23,WDR3,NOP58,PWP2,TRMT112,RCL1
R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	0.085682372469835	-2.4571081633353	146	54	0.0167234437906473	3229	10285	4747,2554,1739,83988,59345,10368,3766,1741,2562,406974,2555,2773,2785,1173,1175,2791,3265,2891,2771,818,2793,2784,5579,5894,2782,5567,5578,2550,3760,2788,1139,1141,54331,27020,55970,7102,5330,2561,1742,2897,108,51764,3759,160,2790,2787,23236,4646,2890,109,9463,4193,2566,1385	NEFL,GABRA1,DLG1,NCALD,GNB4,CACNG3,KCNJ10,DLG3,GABRB3,MIR197,GABRA2,GNAI3,GNG3,AP2M1,AP2S1,GNG11,HRAS,GRIA2,GNAI2,CAMK2G,GNGT2,GNB3,PRKCB,RAF1,GNB1,PRKACB,PRKCA,GABBR1,KCNJ3,GNG7,CHRNA7,CHRNB2,GNG2,NPTN,GNG12,TSPAN7,PLCB2,GABRB2,DLG4,GRIK1,ADCY2,GNG13,KCNJ2,AP2A1,GNG10,GNG5,PLCB1,MYO6,GRIA1,ADCY3,PICK1,MDM2,GABRG2,CREB1
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.0857690700052622	-2.45609682692932	48	20	0.0061938680706101	3229	10285	2071,9219,100302240,4331,57504,51082,1022,5931,53615,84172,5441,404672,30834,2966,5928,2968,79101,902,54700,5435	ERCC3,MTA2,MIR1304,MNAT1,MTA3,POLR1D,CDK7,RBBP7,MBD3,POLR1B,POLR2L,GTF2H5,POLR1H,GTF2H2,RBBP4,GTF2H4,TAF1D,CCNH,RRN3,POLR2F
R-HSA-112382	Formation of RNA Pol II elongation complex	0.0878896056887926	-2.43167373283284	65	26	0.00805202849179312	3229	10285	5435,6827,6921,5436,2963,2966,404672,5441,5433,6917,1022,4331,6829,22916,5431,55840,5432,902,80349,2968,2962,5438,79577,1025,2071,6749	POLR2F,SUPT4H1,ELOC,POLR2G,GTF2F2,GTF2H2,GTF2H5,POLR2L,POLR2D,TCEA1,CDK7,MNAT1,SUPT5H,NCBP2,POLR2B,EAF2,POLR2C,CCNH,SKIC8,GTF2H4,GTF2F1,POLR2I,CDC73,CDK9,ERCC3,SSRP1
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.0878896056887926	-2.43167373283284	65	26	0.00805202849179312	3229	10285	6829,22916,5431,55840,4331,1022,6917,2966,404672,5441,5433,6827,5436,6921,2963,5435,2071,6749,1025,79577,2962,5438,5432,902,80349,2968	SUPT5H,NCBP2,POLR2B,EAF2,MNAT1,CDK7,TCEA1,GTF2H2,GTF2H5,POLR2L,POLR2D,SUPT4H1,POLR2G,ELOC,GTF2F2,POLR2F,ERCC3,SSRP1,CDK9,CDC73,GTF2F1,POLR2I,POLR2C,CCNH,SKIC8,GTF2H4
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.0884623548003623	-2.42517818695095	21	10	0.00309693403530505	3229	10285	3265,2248,6464,3845,2260,8074,27006,8822,2246,2255	HRAS,FGF3,SHC1,KRAS,FGFR1,FGF23,FGF22,FGF17,FGF1,FGF10
R-HSA-1227986	Signaling by ERBB2	0.0892955057172273	-2.41580412028076	51	21	0.0065035614741406	3229	10285	7314,7525,3320,5290,207,10000,7311,6233,5578,208,3845,3265,2549,5581,5295,6714,1839,10193,6464,9101,10273	UBB,YES1,HSP90AA1,PIK3CA,AKT1,AKT3,UBA52,RPS27A,PRKCA,AKT2,KRAS,HRAS,GAB1,PRKCE,PIK3R1,SRC,HBEGF,RNF41,SHC1,USP8,STUB1
R-HSA-389957	Prefoldin mediated transfer of substrate  to CCT/TriC	0.0893408264174664	-2.41529671284948	29	13	0.00402601424589656	3229	10285	10471,5203,10574,5202,10383,60,7846,6950,10576,22948,5201,5204,10694	PFDN6,PFDN4,CCT7,PFDN2,TUBB4B,ACTB,TUBA1A,TCP1,CCT2,CCT5,PFDN1,PFDN5,CCT8
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	0.0913706619084122	-2.39283083773373	40	17	0.00526478786001858	3229	10285	28232,8884,7355,213,11309,28234,51000,10559,389812,286256,23169,55343,84912,392399,3933,2030,6579	SLCO3A1,SLC5A6,SLC35A2,ALB,SLCO2B1,SLCO1B3,SLC35B3,SLC35A1,LCN15,LCN12,SLC35D1,SLC35C1,SLC35B4,LCN9,LCN1,SLC29A1,SLCO1A2
R-HSA-1170546	Prolactin receptor signaling	0.0938231374840739	-2.36634378511387	16	8	0.00247754722824404	3229	10285	2688,2690,6776,1442,5781,6500,3717,5617	GH1,GHR,STAT5A,CSH1,PTPN11,SKP1,JAK2,PRL
R-HSA-1295596	Spry regulation of FGF signaling	0.0938231374840739	-2.36634378511387	16	8	0.00247754722824404	3229	10285	5516,5781,6714,6233,7311,5518,867,7314	PPP2CB,PTPN11,SRC,RPS27A,UBA52,PPP2R1A,CBL,UBB
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.0938231374840739	-2.36634378511387	16	8	0.00247754722824404	3229	10285	5290,3320,867,6464,2549,3265,5295,3845	PIK3CA,HSP90AA1,CBL,SHC1,GAB1,HRAS,PIK3R1,KRAS
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.0938231374840739	-2.36634378511387	16	8	0.00247754722824404	3229	10285	5290,3320,867,5295,3845,6464,2549,3265	PIK3CA,HSP90AA1,CBL,PIK3R1,KRAS,SHC1,GAB1,HRAS
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	0.0938231374840739	-2.36634378511387	16	8	0.00247754722824404	3229	10285	6500,5604,3551,4790,7314,23291,7311,6233	SKP1,MAP2K1,IKBKB,NFKB1,UBB,FBXW11,UBA52,RPS27A
R-HSA-204626	Hypusine synthesis from eIF5A-lysine	0.0945926488178374	-2.35817551400042	4	3	0.000929080210591514	3229	10285	1725,56648,83475	DHPS,EIF5A2,DOHH
R-HSA-69560	Transcriptional activation of p53 responsive genes	0.0945926488178374	-2.35817551400042	4	3	0.000929080210591514	3229	10285	57060,1026,7157	PCBP4,CDKN1A,TP53
R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21	0.0945926488178374	-2.35817551400042	4	3	0.000929080210591514	3229	10285	57060,1026,7157	PCBP4,CDKN1A,TP53
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.0945926488178374	-2.35817551400042	4	3	0.000929080210591514	3229	10285	3980,5423,328	LIG3,POLB,APEX1
R-HSA-888593	Reuptake of GABA	0.0945926488178374	-2.35817551400042	4	3	0.000929080210591514	3229	10285	6538,6539,6529	SLC6A11,SLC6A12,SLC6A1
R-HSA-4551638	SUMOylation of chromatin organization proteins	0.0945926488178374	-2.35817551400042	4	3	0.000929080210591514	3229	10285	7329,8554,6613	UBE2I,PIAS1,SUMO2
R-HSA-211163	AKT-mediated inactivation of FOXO1A	0.0945926488178374	-2.35817551400042	4	3	0.000929080210591514	3229	10285	208,207,10000	AKT2,AKT1,AKT3
R-HSA-71288	Creatine metabolism	0.0949651746590342	-2.35424503712588	11	6	0.00185816042118303	3229	10285	6534,6538,2593,6535,1152,6539	SLC6A7,SLC6A11,GAMT,SLC6A8,CKB,SLC6A12
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.0949651746590342	-2.35424503712588	11	6	0.00185816042118303	3229	10285	3551,7335,7189,7334,57162,246330	IKBKB,UBE2V1,TRAF6,UBE2N,PELI1,PELI3
R-HSA-5660526	Response to metal ions	0.0949651746590342	-2.35424503712588	11	6	0.00185816042118303	3229	10285	4493,4504,4489,4499,4502,4501	MT1E,MT3,MT1A,MT1M,MT2A,MT1X
R-HSA-937039	IRAK1 recruits IKK complex	0.0949651746590342	-2.35424503712588	11	6	0.00185816042118303	3229	10285	3551,7335,7189,246330,7334,57162	IKBKB,UBE2V1,TRAF6,PELI3,UBE2N,PELI1
R-HSA-5661231	Metallothioneins bind metals	0.0949651746590342	-2.35424503712588	11	6	0.00185816042118303	3229	10285	4493,4504,4501,4499,4489,4502	MT1E,MT3,MT1X,MT1M,MT1A,MT2A
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.0949651746590342	-2.35424503712588	11	6	0.00185816042118303	3229	10285	6118,5425,57804,6119,2237,5111	RPA2,POLD2,POLD4,RPA3,FEN1,PCNA
R-HSA-429914	Deadenylation-dependent mRNA decay	0.0955403569275895	-2.3482065351304	57	23	0.00712294828120161	3229	10285	9337,51010,1974,51013,9775,57819,25804,54512,4848,80153,1977,23658,11157,26986,246175,11340,167227,57472,29883,1975,27258,10605,80349	CNOT8,EXOSC3,EIF4A2,EXOSC1,EIF4A3,LSM2,LSM4,EXOSC4,CNOT2,EDC3,EIF4E,LSM5,LSM6,PABPC1,CNOT6L,EXOSC8,DCP2,CNOT6,CNOT7,EIF4B,LSM3,PAIP1,SKIC8
R-HSA-375280	Amine ligand-binding receptors	0.0958636390752475	-2.34482852357555	43	18	0.00557448126354909	3229	10285	153,11255,1131,1814,148,3356,3355,3361,1132,155,319100,3350,1128,154,1812,1133,134864,3274	ADRB1,HRH3,CHRM3,DRD3,ADRA1A,HTR2A,HTR1F,HTR5A,CHRM4,ADRB3,TAAR6,HTR1A,CHRM1,ADRB2,DRD1,CHRM5,TAAR1,HRH2
R-HSA-75893	TNF signaling	0.0958636390752475	-2.34482852357555	43	18	0.00557448126354909	3229	10285	7128,10454,56957,9099,10616,329,23118,3551,90268,25999,6610,7124,7314,6233,7311,7186,8887,7185	TNFAIP3,TAB1,OTUD7B,USP2,RBCK1,BIRC2,TAB2,IKBKB,OTULIN,CLIP3,SMPD2,TNF,UBB,RPS27A,UBA52,TRAF2,TAX1BP1,TRAF1
R-HSA-196071	Metabolism of steroid hormones	0.0960367798383482	-2.34302403757117	32	14	0.00433570764942707	3229	10285	3290,1589,79644,134429,1584,3293,1586,83930,1585,3972,6770,51170,231,3292	HSD11B1,CYP21A2,SRD5A3,STARD4,CYP11B1,HSD17B3,CYP17A1,STARD3NL,CYP11B2,LHB,STAR,HSD17B11,AKR1B1,HSD17B1
R-HSA-73863	RNA Polymerase I Transcription Termination	0.0960367798383482	-2.34302403757117	32	14	0.00433570764942707	3229	10285	1022,51082,4331,100302240,2071,5435,902,79101,2968,2966,30834,5441,404672,84172	CDK7,POLR1D,MNAT1,MIR1304,ERCC3,POLR2F,CCNH,TAF1D,GTF2H4,GTF2H2,POLR1H,POLR2L,GTF2H5,POLR1B
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.0961858803429829	-2.3414727060643	77	30	0.00929080210591514	3229	10285	4088,7323,7314,5500,7029,7048,9040,867,7311,2280,5501,6233,7321,9958,10273,6667,50848,60436,3726,57154,4087,7514,1874,1024,50855,5045,1025,4738,4609,4089	SMAD3,UBE2D3,UBB,PPP1CB,TFDP2,TGFBR2,UBE2M,CBL,UBA52,FKBP1A,PPP1CC,RPS27A,UBE2D1,USP15,STUB1,SP1,F11R,TGIF2,JUNB,SMURF1,SMAD2,XPO1,E2F4,CDK8,PARD6A,FURIN,CDK9,NEDD8,MYC,SMAD4
R-HSA-6784531	tRNA processing in the nucleus	0.0983051369914737	-2.3196789948885	60	24	0.00743264168473212	3229	10285	129401,51493,29894,51367,54913,100126351,51637,1653,9972,23636,283989,11260,57122,100302196,10898,11097,10978,11102,79042,79897,5901,10762,10248,79023	NUP35,RTCB,CPSF1,POP5,RPP25,MIR939,RTRAF,DDX1,NUP153,NUP62,TSEN54,XPOT,NUP107,MIR1234,CPSF4,NUP42,CLP1,RPP14,TSEN34,RPP21,RAN,NUP50,POP7,NUP37
R-HSA-190872	Transport of connexons to the plasma membrane	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	2697,2706	GJA1,GJB2
R-HSA-3359478	Defective MUT causes methylmalonic aciduria mut type	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	4594,166785	MMUT,MMAA
R-HSA-5602566	TICAM1 deficiency - HSE	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	148022,7098	TICAM1,TLR3
R-HSA-5652227	Fructose biosynthesis	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	6652,231	SORD,AKR1B1
R-HSA-3359473	Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	27249,25974	MMADHC,MMACHC
R-HSA-73930	Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	328,5423	APEX1,POLB
R-HSA-3359475	Defective MMAA causes methylmalonic aciduria type cblA	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	166785,4594	MMAA,MMUT
R-HSA-164939	Nef mediated downregulation of CD28 cell surface expression	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	940,1173	CD28,AP2M1
R-HSA-5545619	XAV939 inhibits tankyrase, stabilizing AXIN	0.0985451391464062	-2.31724057032989	2	2	0.00061938680706101	3229	10285	80351,8658	TNKS2,TNKS
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.101049543944203	-2.29214434831238	86	33	0.0102198823165067	3229	10285	7410,2209,998,10094,2212,60,8976,3326,5296,10768,5581,917,5295,51517,7525,3320,5290,919,10787,26999,10097,4690,4620,196051,63916,10810,9844,2268,6714,1072,6850,23646,10109	VAV2,FCGR1A,CDC42,ARPC3,FCGR2A,ACTB,WASL,HSP90AB1,PIK3R2,AHCYL1,PRKCE,CD3G,PIK3R1,NCKIPSD,YES1,HSP90AA1,PIK3CA,CD247,NCKAP1,CYFIP2,ACTR2,NCK1,MYH2,PLPP4,ELMO2,WASF3,ELMO1,FGR,SRC,CFL1,SYK,PLD3,ARPC2
R-HSA-1630316	Glycosaminoglycan metabolism	0.101592130898314	-2.28678919862555	124	46	0.0142458965624032	3229	10285	3340,54480,83539,55790,10678,11041,2683,2131,55454,3073,9955,8692,6484,79586,9435,3038,222537,3074,9348,8702,56548,6483,6385,5549,26035,6383,51000,166012,4060,4969,2331,6482,8703,9653,9060,9331,2817,10057,768213,9957,2239,50515,10090,11285,8534,11261	NDST1,CHPF2,CHST9,CSGALNACT1,B3GNT2,B4GAT1,B4GALT1,EXT1,CSGALNACT2,HEXA,HS3ST3A1,HYAL2,ST3GAL4,CHPF,CHST2,HAS3,HS3ST5,HEXB,NDST3,B4GALT4,CHST7,ST3GAL2,SDC4,PRELP,GLCE,SDC2,SLC35B3,CHST13,LUM,OGN,FMOD,ST3GAL1,B4GALT3,HS2ST1,PAPSS2,B4GALT6,GPC1,ABCC5,MIR671,HS3ST1,GPC4,CHST11,UST,B4GALT7,CHST1,CHP1
R-HSA-2682334	EPH-Ephrin signaling	0.10499815229308	-2.25381252618821	95	36	0.0111489625270982	3229	10285	103910,9475,1969,6386,5062,6714,5664,6383,1944,23385,4318,6093,7422,7074,1946,10109,10627,1072,1947,2043,8976,7410,10094,998,60,2051,55851,1175,4637,3265,10097,160,1173,7525,3320,51107	MYL12B,ROCK2,EPHA2,SDCBP,PAK2,SRC,PSEN2,SDC2,EFNA3,NCSTN,MMP9,ROCK1,VEGFA,TIAM1,EFNA5,ARPC2,MYL12A,CFL1,EFNB1,EPHA4,WASL,VAV2,ARPC3,CDC42,ACTB,EPHB6,PSENEN,AP2S1,MYL6,HRAS,ACTR2,AP2A1,AP2M1,YES1,HSP90AA1,APH1A
R-HSA-380994	ATF4 activates genes	0.106646124978208	-2.23823916873136	27	12	0.00371632084236606	3229	10285	468,51010,51013,4800,54512,4801,6347,467,3576,11340,167227,1649	ATF4,EXOSC3,EXOSC1,NFYA,EXOSC4,NFYB,CCL2,ATF3,CXCL8,EXOSC8,DCP2,DDIT3
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.106646124978208	-2.23823916873136	27	12	0.00371632084236606	3229	10285	9958,10273,4088,4087,57154,7048,7514,7314,5500,6233,5501,7311	USP15,STUB1,SMAD3,SMAD2,SMURF1,TGFBR2,XPO1,UBB,PPP1CB,RPS27A,PPP1CC,UBA52
R-HSA-5654716	Downstream signaling of activated FGFR4	0.106646124978208	-2.23823916873136	27	12	0.00371632084236606	3229	10285	6464,8823,10817,5295,8822,2246,3265,2549,8074,3845,5781,5290	SHC1,FGF16,FRS3,PIK3R1,FGF17,FGF1,HRAS,GAB1,FGF23,KRAS,PTPN11,PIK3CA
R-HSA-71387	Metabolism of carbohydrates	0.112572074176004	-2.18416160312999	296	103	0.031898420563642	3229	10285	11261,669,10090,22934,2026,5837,10762,2817,5518,8402,7314,9331,5567,8703,9653,6482,51000,6383,4060,5549,26035,6652,2542,6385,57122,7360,9348,10007,5255,4190,5106,3074,2203,9435,231,2997,6576,5223,9955,3073,2539,79023,51084,693216,2632,129401,6120,2131,280,85414,9972,11041,55790,3340,8604,8534,8789,5257,11285,2239,50515,768213,2023,9957,10057,9060,7311,5230,1468,4969,2331,5507,166012,10327,5091,6483,11097,56548,8702,132789,222537,3038,79586,5834,5516,8692,6515,6484,2582,6513,55454,5208,92579,6233,2597,5631,2683,5236,23636,10678,5260,83539,54480	CHP1,BPGM,UST,RPIA,ENO2,PYGM,NUP50,GPC1,PPP2R1A,SLC25A11,UBB,B4GALT6,PRKACB,B4GALT3,HS2ST1,ST3GAL1,SLC35B3,SDC2,LUM,PRELP,GLCE,SORD,SLC37A4,SDC4,NUP107,UGP2,NDST3,GNPDA1,PHKA1,MDH1,PCK2,HEXB,FBP1,CHST2,AKR1B1,GYS1,SLC25A1,PGAM1,HS3ST3A1,HEXA,G6PD,NUP37,CRYL1,MIR631,GBE1,NUP35,RPE,EXT1,AMY2B,SLC45A3,NUP153,B4GAT1,CSGALNACT1,NDST1,SLC25A12,CHST1,FBP2,PHKB,B4GALT7,GPC4,CHST11,MIR671,ENO1,HS3ST1,ABCC5,PAPSS2,UBA52,PGK1,SLC25A10,OGN,FMOD,PPP1R3C,CHST13,AKR1A1,PC,ST3GAL2,NUP42,CHST7,B4GALT4,GNPDA2,HS3ST5,HAS3,CHPF,PYGB,PPP2CB,HYAL2,SLC2A3,ST3GAL4,GALE,SLC2A1,CSGALNACT2,PFKFB2,G6PC3,RPS27A,GAPDH,PRPS1,B4GALT1,PGM1,NUP62,B3GNT2,PHKG1,CHST9,CHPF2
R-HSA-420029	Tight junction interactions	0.11399491575745	-2.17160143020105	30	13	0.00402601424589656	3229	10285	23562,50855,5010,92359,53842,9074,1364,9080,9069,50848,9073,1365,9076	CLDN14,PARD6A,CLDN11,CRB3,CLDN22,CLDN6,CLDN4,CLDN9,CLDN12,F11R,CLDN8,CLDN3,CLDN1
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	0.114521711739653	-2.16699085178348	131	48	0.0148652833694642	3229	10285	208,79837,2549,5516,3815,207,10000,5290,8503,1026,8823,8870,2252,942,2931,7157,572,1839,2248,6464,2260,8074,7462,5728,4233,940,8394,5529,29851,5295,5296,1385,1027,5525,2246,4193,5781,57690,5518,27006,6850,6714,26523,8822,941,2255,118788,4343	AKT2,PIP4K2C,GAB1,PPP2CB,KIT,AKT1,AKT3,PIK3CA,PIK3R3,CDKN1A,FGF16,IER3,FGF7,CD86,GSK3A,TP53,BAD,HBEGF,FGF3,SHC1,FGFR1,FGF23,LAT2,PTEN,MET,CD28,PIP5K1A,PPP2R5E,ICOS,PIK3R1,PIK3R2,CREB1,CDKN1B,PPP2R5A,FGF1,MDM2,PTPN11,TNRC6C,PPP2R1A,FGF22,SYK,SRC,AGO1,FGF17,CD80,FGF10,PIK3AP1,MOV10
R-HSA-209543	p75NTR recruits signalling complexes	0.114665874752013	-2.16573281653314	14	7	0.00216785382471353	3229	10285	7189,3551,4615,8878,7314,6233,7311	TRAF6,IKBKB,MYD88,SQSTM1,UBB,RPS27A,UBA52
R-HSA-917937	Iron uptake and transport	0.11640251881196	-2.15070110464092	44	18	0.00557448126354909	3229	10285	534,528,8992,7018,523,2512,57192,9429,3163,90423,51310,9550,7037,4891,51382,533,2495,79901	ATP6V1G2,ATP6V1C1,ATP6V0E1,TF,ATP6V1A,FTL,MCOLN1,ABCG2,HMOX2,ATP6V1E2,SLC22A17,ATP6V1G1,TFRC,SLC11A2,ATP6V1D,ATP6V0B,FTH1,CYBRD1
R-HSA-194002	Glucocorticoid biosynthesis	0.116716054222199	-2.14801118083766	9	5	0.00154846701765252	3229	10285	1586,3290,1589,1585,1584	CYP17A1,HSD11B1,CYP21A2,CYP11B2,CYP11B1
R-HSA-162592	Integration of provirus	0.116716054222199	-2.14801118083766	9	5	0.00154846701765252	3229	10285	3159,8815,5478,3836,7520	HMGA1,BANF1,PPIA,KPNA1,XRCC5
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.116716054222199	-2.14801118083766	9	5	0.00154846701765252	3229	10285	4087,4089,2280,7048,4088	SMAD2,SMAD4,FKBP1A,TGFBR2,SMAD3
R-HSA-426486	Small interfering RNA (siRNA) biogenesis	0.116716054222199	-2.14801118083766	9	5	0.00154846701765252	3229	10285	26523,23405,8575,7247,7257	AGO1,DICER1,PRKRA,TSN,TSNAX
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	0.116716054222199	-2.14801118083766	9	5	0.00154846701765252	3229	10285	7311,6233,7314,867,207	UBA52,RPS27A,UBB,CBL,AKT1
R-HSA-2428933	SHC-related events triggered by IGF1R	0.116716054222199	-2.14801118083766	9	5	0.00154846701765252	3229	10285	3845,3480,3265,3479,6464	KRAS,IGF1R,HRAS,IGF1,SHC1
R-HSA-112411	MAPK1 (ERK2) activation	0.116716054222199	-2.14801118083766	9	5	0.00154846701765252	3229	10285	3717,3716,3569,3572,5781	JAK2,JAK1,IL6,IL6ST,PTPN11
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.117932292982297	-2.13764460748159	93	35	0.0108392691235677	3229	10285	1020,6118,116028,4193,80010,6882,8851,6749,5571,8445,5982,1460,11073,7311,6794,6233,7314,5932,5984,890,7157,6879,6881,6880,94241,1457,4683,672,5564,6873,5983,6119,5810,5985,8550	CDK5,RPA2,RMI2,MDM2,RMI1,TAF11,CDK5R1,SSRP1,PRKAG1,DYRK2,RFC2,CSNK2B,TOPBP1,UBA52,STK11,RPS27A,UBB,RBBP8,RFC4,CCNA2,TP53,TAF7,TAF10,TAF9,TP53INP1,CSNK2A1,NBN,BRCA1,PRKAB1,TAF2,RFC3,RPA3,RAD1,RFC5,MAPKAPK5
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.118163341800335	-2.13568735916558	22	10	0.00309693403530505	3229	10285	1479,10914,22916,10898,23283,100302196,100126351,29894,10978,53981	CSTF3,PAPOLA,NCBP2,CPSF4,CSTF2T,MIR1234,MIR939,CPSF1,CLP1,CPSF2
R-HSA-373753	Nephrin interactions	0.118163341800335	-2.13568735916558	22	10	0.00309693403530505	3229	10285	5295,81,8976,8573,23607,5296,6711,5290,4690,6709	PIK3R1,ACTN4,WASL,CASK,CD2AP,PIK3R2,SPTBN1,PIK3CA,NCK1,SPTAN1
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.120031707788254	-2.11999933953432	99	37	0.0114586559306287	3229	10285	9146,9341,8322,55707,9892,27348,84251,51138,7311,8673,6233,9318,7314,867,3949,8301,29988,4738,7037,1080,917,115548,154,1856,920,10987,6845,7018,160,25977,1173,64708,6844,50813,1175,127833,6869	HGS,VAMP3,FZD4,NECAP2,SNAP91,TOR1B,SGIP1,COPS4,UBA52,VAMP8,RPS27A,COPS2,UBB,CBL,LDLR,PICALM,SLC2A8,NEDD8,TFRC,CFTR,CD3G,FCHO2,ADRB2,DVL2,CD4,COPS5,VAMP7,TF,AP2A1,NECAP1,AP2M1,COPS7B,VAMP2,COPS7A,AP2S1,SYT2,TACR1
R-HSA-4085001	Sialic acid metabolism	0.120423240116305	-2.11674274051239	33	14	0.00433570764942707	3229	10285	8869,7903,5476,10559,6480,6484,256435,140838,6482,4758,6483,26503,29906,55907	ST3GAL5,ST8SIA4,CTSA,SLC35A1,ST6GAL1,ST3GAL4,ST6GALNAC3,NANP,ST3GAL1,NEU1,ST3GAL2,SLC17A5,ST8SIA5,CMAS
R-HSA-163359	Glucagon signaling in metabolic regulation	0.120423240116305	-2.11674274051239	33	14	0.00433570764942707	3229	10285	54331,55970,109,2784,2785,51764,108,2782,5567,2788,2790,59345,2791,2787	GNG2,GNG12,ADCY3,GNB3,GNG3,GNG13,ADCY2,GNB1,PRKACB,GNG7,GNG10,GNB4,GNG11,GNG5
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.123997142064691	-2.0874967615081	73	28	0.00867141529885413	3229	10285	157807,9146,23557,6643,2495,8906,8301,8905,4952,27243,8907,3312,8673,6845,2512,7164,375,8773,134829,7037,27131,388552,8775,5878,7163,1785,6844,25977	CLVS1,HGS,SNAPIN,SNX2,FTH1,AP1G2,PICALM,AP1S2,OCRL,CHMP2A,AP1M1,HSPA8,VAMP8,VAMP7,FTL,TPD52L1,ARF1,SNAP23,CLVS2,TFRC,SNX5,BLOC1S3,NAPA,RAB5C,TPD52,DNM2,VAMP2,NECAP1
R-HSA-421837	Clathrin derived vesicle budding	0.123997142064691	-2.0874967615081	73	28	0.00867141529885413	3229	10285	6844,25977,7163,5878,1785,27131,7037,134829,388552,8775,7164,2512,6845,375,8773,4952,27243,8907,8673,3312,8906,8301,8905,9146,23557,2495,6643,157807	VAMP2,NECAP1,TPD52,RAB5C,DNM2,SNX5,TFRC,CLVS2,BLOC1S3,NAPA,TPD52L1,FTL,VAMP7,ARF1,SNAP23,OCRL,CHMP2A,AP1M1,VAMP8,HSPA8,AP1G2,PICALM,AP1S2,HGS,SNAPIN,FTH1,SNX2,CLVS1
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.126893629520144	-2.06440610630878	53	21	0.0065035614741406	3229	10285	22948,10576,56623,149371,55770,123016,84100,54585,84747,8195,10694,55763,5147,2847,129880,6102,378,11336,10640,8766,6950	CCT5,CCT2,INPP5E,EXOC8,EXOC2,TTC8,ARL6,LZTFL1,UNC119B,MKKS,CCT8,EXOC1,PDE6D,MCHR1,BBS5,RP2,ARF4,EXOC3,EXOC5,RAB11A,TCP1
R-HSA-982772	Growth hormone receptor signaling	0.127491283536042	-2.05970728114381	25	11	0.00340662743883555	3229	10285	1442,5770,6772,6776,1154,2690,2688,8835,3717,5617,9021	CSH1,PTPN1,STAT1,STAT5A,CISH,GHR,GH1,SOCS2,JAK2,PRL,SOCS3
R-HSA-429947	Deadenylation of mRNA	0.127491283536042	-2.05970728114381	25	11	0.00340662743883555	3229	10285	246175,1974,26986,9337,1977,10605,1975,29883,4848,57472,9775	CNOT6L,EIF4A2,PABPC1,CNOT8,EIF4E,PAIP1,EIF4B,CNOT7,CNOT2,CNOT6,EIF4A3
R-HSA-416476	G alpha (q) signalling events	0.128981048956164	-2.04808979272896	192	68	0.0210591514400743	3229	10285	2767,10235,1131,2782,5997,2788,5032,3060,2147,5588,54331,1133,55970,6375,553,8477,5330,680,57406,84432,5737,51764,3356,84539,6869,2790,2787,5028,23236,10911,6863,10161,1902,387129,4829,5295,10287,2797,2911,5296,6870,51738,148,4295,1909,59345,2840,2837,1128,6368,5021,2847,114814,26090,27334,2785,5290,9630,9170,2776,2791,5731,2796,2925,8503,2793,2784,5581	GNA11,RASGRP2,CHRM3,GNB1,RGS2,GNG7,P2RY11,HCRT,F2,PRKCQ,GNG2,CHRM5,GNG12,XCL1,AVPR1B,GPR65,PLCB2,BRS3,ABHD6,PROK1,PTGFR,GNG13,HTR2A,MCHR2,TACR1,GNG10,GNG5,P2RY1,PLCB1,UTS2,TAC1,LPAR6,LPAR1,NPSR1,NMBR,PIK3R1,RGS19,GNRH2,GRM1,PIK3R2,TACR3,GHRL,ADRA1A,MLN,EDNRA,GNB4,GPR17,UTS2R,CHRM1,CCL23,OXTR,MCHR1,GNRHR2,ABHD12,P2RY10,GNG3,PIK3CA,GNA14,LPAR2,GNAQ,GNG11,PTGER1,GNRH1,GRPR,PIK3R3,GNGT2,GNB3,PRKCE
R-HSA-3232118	SUMOylation of transcription factors	0.130154757740435	-2.03903109238616	17	8	0.00247754722824404	3229	10285	7341,6613,4193,7329,8554,6612,7157,4286	SUMO1,SUMO2,MDM2,UBE2I,PIAS1,SUMO3,TP53,MITF
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	0.130154757740435	-2.03903109238616	17	8	0.00247754722824404	3229	10285	7314,7048,7311,2280,50855,50848,6233,57154	UBB,TGFBR2,UBA52,FKBP1A,PARD6A,F11R,RPS27A,SMURF1
R-HSA-2033519	Activated point mutants of FGFR2	0.130154757740435	-2.03903109238616	17	8	0.00247754722824404	3229	10285	8823,2248,8074,2252,27006,8822,2246,2255	FGF16,FGF3,FGF23,FGF7,FGF22,FGF17,FGF1,FGF10
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	0.130154757740435	-2.03903109238616	17	8	0.00247754722824404	3229	10285	6804,6844,10815,5864,6616,8499,6812,8541	STX1A,VAMP2,CPLX1,RAB3A,SNAP25,PPFIA2,STXBP1,PPFIA3
R-HSA-165159	mTOR signalling	0.131053244813884	-2.03215158939804	39	16	0.00495509445648808	3229	10285	5571,5564,55004,7529,8649,51719,207,6009,1977,10325,6794,10670,1975,208,55437,28956	PRKAG1,PRKAB1,LAMTOR1,YWHAB,LAMTOR3,CAB39,AKT1,RHEB,EIF4E,RRAGB,STK11,RRAGA,EIF4B,AKT2,STRADB,LAMTOR2
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.133257569515229	-2.01547141068112	94	35	0.0108392691235677	3229	10285	5781,942,27006,5518,2248,1839,6714,941,8822,118788,2255,3815,5516,4233,2549,5728,79837,208,8074,2260,8394,5529,5290,207,10000,940,8823,5296,5295,29851,8503,2252,8870,2246,5525	PTPN11,CD86,FGF22,PPP2R1A,FGF3,HBEGF,SRC,CD80,FGF17,PIK3AP1,FGF10,KIT,PPP2CB,MET,GAB1,PTEN,PIP4K2C,AKT2,FGF23,FGFR1,PIP5K1A,PPP2R5E,PIK3CA,AKT1,AKT3,CD28,FGF16,PIK3R2,PIK3R1,ICOS,PIK3R3,FGF7,IER3,FGF1,PPP2R5A
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	0.135415985157465	-1.9994038667023	28	12	0.00371632084236606	3229	10285	929,1613,8743,353376,1612,7098,7099,148022,356,355,23643,7186	CD14,DAPK3,TNFSF10,TICAM2,DAPK1,TLR3,TLR4,TICAM1,FASLG,FAS,LY96,TRAF2
R-HSA-72306	tRNA processing	0.137121196263196	-1.98689009996422	109	40	0.0123877361412202	3229	10285	51367,29894,51493,129401,3028,54974,11260,283989,51605,1653,54913,51637,100126351,23636,9972,10978,54482,11102,115708,129450,10898,57122,60487,100302196,90353,11097,55644,79691,57570,5901,10762,10248,24140,51504,127253,79023,79042,23536,81605,79897	POP5,CPSF1,RTCB,NUP35,HSD17B10,THG1L,XPOT,TSEN54,TRMT6,DDX1,RPP25,RTRAF,MIR939,NUP62,NUP153,CLP1,TRMT13,RPP14,TRMT61A,TYW5,CPSF4,NUP107,TRMT11,MIR1234,CTU1,NUP42,OSGEP,QTRT2,TRMT5,RAN,NUP50,POP7,FTSJ1,TRMT112,TYW3,NUP37,TSEN34,ADAT1,URM1,RPP21
R-HSA-211945	Phase 1 - Functionalization of compounds	0.137121196263196	-1.98689009996422	109	40	0.0123877361412202	3229	10285	1565,1572,55902,134147,1545,124,54996,11283,1727,64816,1558,1543,3326,126410,2326,51302,1592,2327,125,285440,1562,5447,80777,1594,874,1586,10728,1577,1585,120227,1581,196743,1559,1584,1593,1589,2052,9049,2328,66002	CYP2D6,CYP2F1,ACSS2,CMBL,CYP1B1,ADH1A,MTARC2,CYP4F8,CYB5R3,CYP3A43,CYP2C8,CYP1A1,HSP90AB1,CYP4F22,FMO1,CYP39A1,CYP26A1,FMO2,ADH1B,CYP4V2,CYP2C18,POR,CYB5B,CYP27B1,CBR3,CYP17A1,PTGES3,CYP3A5,CYP11B2,CYP2R1,CYP7A1,PAOX,CYP2C9,CYP11B1,CYP27A1,CYP21A2,EPHX1,AIP,FMO3,CYP4F12
R-HSA-2022857	Keratan sulfate degradation	0.14107526554988	-1.95846173279746	12	6	0.00185816042118303	3229	10285	4060,4969,5549,3073,3074,2331	LUM,OGN,PRELP,HEXA,HEXB,FMOD
R-HSA-176974	Unwinding of DNA	0.14107526554988	-1.95846173279746	12	6	0.00185816042118303	3229	10285	84296,4172,4173,84515,64785,4175	GINS4,MCM3,MCM4,MCM8,GINS3,MCM6
R-HSA-114452	Activation of BH3-only proteins	0.142199065743297	-1.95052733165359	31	13	0.00402601424589656	3229	10285	7534,7529,2810,208,8655,5366,7157,7532,572,7533,7029,10000,207	YWHAZ,YWHAB,SFN,AKT2,DYNLL1,PMAIP1,TP53,YWHAG,BAD,YWHAH,TFDP2,AKT3,AKT1
R-HSA-3000170	Syndecan interactions	0.142561898822738	-1.94797899588469	20	9	0.00278724063177454	3229	10285	51399,3673,3685,6383,5578,3655,8573,6385,3693	TRAPPC4,ITGA2,ITGAV,SDC2,PRKCA,ITGA6,CASK,SDC4,ITGB5
R-HSA-163560	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	0.142561898822738	-1.94797899588469	20	9	0.00278724063177454	3229	10285	2167,857,2173,646486,2171,5500,51099,5501,5567	FABP4,CAV1,FABP7,FABP12,FABP5,PPP1CB,ABHD5,PPP1CC,PRKACB
R-HSA-448706	Interleukin-1 processing	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	3553,3552,3606,4790	IL1B,IL1A,IL18,NFKB1
R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	3751,3752,30818,30819	KCND2,KCND3,KCNIP3,KCNIP2
R-HSA-447038	NrCAM interactions	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	6900,1739,1741,1742	CNTN2,DLG1,DLG3,DLG4
R-HSA-73943	Reversal of alkylation damage by DNA dioxygenases	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	54890,51008,121642,221120	ALKBH5,ASCC1,ALKBH2,ALKBH3
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	4087,4089,4088,7048	SMAD2,SMAD4,SMAD3,TGFBR2
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	4087,4089,7048,4088	SMAD2,SMAD4,TGFBR2,SMAD3
R-HSA-3656225	Defective CHST6 causes MCDC1	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	4969,5549,2331,4060	OGN,PRELP,FMOD,LUM
R-HSA-3656243	Defective ST3GAL3 causes MCT12 and EIEE15	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	2331,4969,5549,4060	FMOD,OGN,PRELP,LUM
R-HSA-3656244	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	2331,4969,5549,4060	FMOD,OGN,PRELP,LUM
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	328,2237,5423,10038	APEX1,FEN1,POLB,PARP2
R-HSA-2993913	Clearance of Nuclear Envelope Membranes from Chromatin	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	7443,23592,7112,8815	VRK1,LEMD3,TMPO,BANF1
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.144766400467114	-1.93263386692916	7	4	0.00123877361412202	3229	10285	140609,983,91754,891	NEK7,CDK1,NEK9,CCNB1
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding	0.148042476323047	-1.91025604421252	34	14	0.00433570764942707	3229	10285	60,7846,6950,5202,10383,5203,10574,10376,10471,10694,5204,22948,10576,5201	ACTB,TUBA1A,TCP1,PFDN2,TUBB4B,PFDN4,CCT7,TUBA1B,PFDN6,CCT8,PFDN5,CCT5,CCT2,PFDN1
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.148042476323047	-1.91025604421252	34	14	0.00433570764942707	3229	10285	1025,4089,6667,4609,60436,4088,4087,3726,1874,7314,7029,6233,1024,7311	CDK9,SMAD4,SP1,MYC,TGIF2,SMAD3,SMAD2,JUNB,E2F4,UBB,TFDP2,RPS27A,CDK8,UBA52
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.148064485387806	-1.9101073880332	89	33	0.0102198823165067	3229	10285	5868,51552,79090,51762,51693,5873,79961,10981,11031,122553,9367,116442,51399,80006,5870,22931,208,11021,5878,7109,5872,51209,10000,207,414918,27095,5864,58485,81876,51560,5861,2665,9827	RAB5A,RAB14,TRAPPC6A,RAB8B,TRAPPC2L,RAB27A,DENND2D,RAB32,RAB31,TRAPPC6B,RAB9A,RAB39B,TRAPPC4,TRAPPC13,RAB6A,RAB18,AKT2,RAB35,RAB5C,TRAPPC10,RAB13,RAB9B,AKT3,AKT1,DENND6B,TRAPPC3,RAB3A,TRAPPC1,RAB1B,RAB6B,RAB1A,GDI2,RGP1
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.151238767505095	-1.88889544925805	57	22	0.00681325487767111	3229	10285	7163,5878,8301,8905,1785,4952,8907,6844,8673,3312,25977,7164,2512,6845,375,27131,7037,388552,23557,8775,2495,6643	TPD52,RAB5C,PICALM,AP1S2,DNM2,OCRL,AP1M1,VAMP2,VAMP8,HSPA8,NECAP1,TPD52L1,FTL,VAMP7,ARF1,SNX5,TFRC,BLOC1S3,SNAPIN,NAPA,FTH1,SNX2
R-HSA-5620922	BBSome-mediated cargo-targeting to cilium	0.152661445920077	-1.87953258115086	23	10	0.00309693403530505	3229	10285	54585,84100,8195,6950,10694,10576,22948,2847,129880,123016	LZTFL1,ARL6,MKKS,TCP1,CCT8,CCT2,CCT5,MCHR1,BBS5,TTC8
R-HSA-400508	Incretin synthesis, secretion, and inactivation	0.152661445920077	-1.87953258115086	23	10	0.00309693403530505	3229	10285	9789,60559,51764,1803,2784,3952,5080,23478,28972,1499	SPCS2,SPCS3,GNG13,DPP4,GNB3,LEP,PAX6,SEC11A,SPCS1,CTNNB1
R-HSA-1257604	PIP3 activates AKT signaling	0.154110583925488	-1.87008485682452	125	45	0.0139362031588727	3229	10285	8823,8503,1026,2252,8870,2549,5516,3815,208,79837,10000,207,5290,2248,1839,7157,2931,572,942,5296,1385,29851,5295,4193,1027,5525,2246,4233,2260,8074,5728,8394,5529,940,26523,6714,4343,2255,941,8822,118788,5781,27006,57690,5518	FGF16,PIK3R3,CDKN1A,FGF7,IER3,GAB1,PPP2CB,KIT,AKT2,PIP4K2C,AKT3,AKT1,PIK3CA,FGF3,HBEGF,TP53,GSK3A,BAD,CD86,PIK3R2,CREB1,ICOS,PIK3R1,MDM2,CDKN1B,PPP2R5A,FGF1,MET,FGFR1,FGF23,PTEN,PIP5K1A,PPP2R5E,CD28,AGO1,SRC,MOV10,FGF10,CD80,FGF17,PIK3AP1,PTPN11,FGF22,TNRC6C,PPP2R1A
R-HSA-180292	GAB1 signalosome	0.154278561419626	-1.86899547016299	128	46	0.0142458965624032	3229	10285	26523,6714,4343,2255,118788,941,8822,5781,27006,5518,57690,1385,5296,5295,29851,4193,2246,5525,1027,4233,5728,8074,2260,8394,5529,1445,940,2248,1839,572,2931,7157,942,8823,1026,8503,2252,8870,3815,5516,2549,79837,208,5290,10000,207	AGO1,SRC,MOV10,FGF10,PIK3AP1,CD80,FGF17,PTPN11,FGF22,PPP2R1A,TNRC6C,CREB1,PIK3R2,PIK3R1,ICOS,MDM2,FGF1,PPP2R5A,CDKN1B,MET,PTEN,FGF23,FGFR1,PIP5K1A,PPP2R5E,CSK,CD28,FGF3,HBEGF,BAD,GSK3A,TP53,CD86,FGF16,CDKN1A,PIK3R3,FGF7,IER3,KIT,PPP2CB,GAB1,PIP4K2C,AKT2,PIK3CA,AKT3,AKT1
R-HSA-211000	Gene Silencing by RNA	0.154571639750577	-1.86709760240826	137	49	0.0151749767729947	3229	10285	29102,5438,11097,57122,3320,3014,5432,57510,55766,3015,79023,3013,143689,5901,94239,55124,474382,8575,129401,8345,136991,8331,8334,255626,9972,54514,23636,8335,9271,54487,84944,8342,8970,8348,23405,113802,8350,10762,7257,5441,5433,57690,10526,5435,5436,85236,5431,26523,7247	DROSHA,POLR2I,NUP42,NUP107,HSP90AA1,H2AX,POLR2C,XPO5,H2AJ,H2AZ1,NUP37,H2AC7,PIWIL4,RAN,H2AZ2,PIWIL2,H2AB1,PRKRA,NUP35,H2BC9,ASZ1,H2AC14,H2AC6,H2BC1,NUP153,DDX4,NUP62,H2AC4,PIWIL1,DGCR8,MAEL,H2BC14,H2BC11,H2BC17,DICER1,HENMT1,H3C1,NUP50,TSNAX,POLR2L,POLR2D,TNRC6C,IPO8,POLR2F,POLR2G,H2BC12,POLR2B,AGO1,TSN
R-HSA-418555	G alpha (s) signalling events	0.154591777623577	-1.86696732908421	146	52	0.0161040569835862	3229	10285	117579,7433,55970,134864,6019,54331,155,5153,113091,2782,5732,5151,2788,5032,122042,1394,109,387129,154,51764,5136,108,153,2787,2790,5142,3274,11245,406974,3972,170589,10888,1812,319100,59345,5150,5138,79924,2771,5734,2781,7253,2784,2793,151306,7432,10268,5744,2785,2773,2791,2838	RLN3,VIPR1,GNG12,TAAR1,RLN2,GNG2,ADRB3,PDE1B,PTH2,GNB1,PTGER2,PDE8A,GNG7,P2RY11,RXFP2,CRHR1,ADCY3,NPSR1,ADRB2,GNG13,PDE1A,ADCY2,ADRB1,GNG5,GNG10,PDE4B,HRH2,GPR176,MIR197,LHB,GPHA2,GPR83,DRD1,TAAR6,GNB4,PDE7A,PDE2A,ADM2,GNAI2,PTGER4,GNAZ,TSHR,GNB3,GNGT2,GPBAR1,VIP,RAMP3,PTHLH,GNG3,GNAI3,GNG11,GPR15
R-HSA-109703	PKB-mediated events	0.157508300085118	-1.84827712315186	40	16	0.00495509445648808	3229	10285	208,1975,55437,28956,6009,207,10670,6794,10325,1977,8649,51719,5564,5571,55004,7529	AKT2,EIF4B,STRADB,LAMTOR2,RHEB,AKT1,RRAGA,STK11,RRAGB,EIF4E,LAMTOR3,CAB39,PRKAB1,PRKAG1,LAMTOR1,YWHAB
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.158957461579373	-1.83911864979303	15	7	0.00216785382471353	3229	10285	8322,1175,5579,1856,160,1173,5578	FZD4,AP2S1,PRKCB,DVL2,AP2A1,AP2M1,PRKCA
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	0.158957461579373	-1.83911864979303	15	7	0.00216785382471353	3229	10285	29110,7314,6233,3661,7311,22954,6737	TBK1,UBB,RPS27A,IRF3,UBA52,TRIM32,TRIM21
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.158957461579373	-1.83911864979303	15	7	0.00216785382471353	3229	10285	27258,80153,167227,25804,57819,23658,11157	LSM3,EDC3,DCP2,LSM4,LSM2,LSM5,LSM6
R-HSA-975576	N-glycan antennae elongation in the medial/trans-Golgi	0.16099250542651	-1.82639746522706	26	11	0.00340662743883555	3229	10285	6480,6484,11320,2683,2530,9486,3972,8702,9331,11282,8703	ST6GAL1,ST3GAL4,MGAT4A,B4GALT1,FUT8,CHST10,LHB,B4GALT4,B4GALT6,MGAT4B,B4GALT3
R-HSA-912694	Regulation of IFNA signaling	0.16099250542651	-1.82639746522706	26	11	0.00340662743883555	3229	10285	3447,3454,6773,9021,5781,3440,3716,3446,5770,6772,3456	IFNA13,IFNAR1,STAT2,SOCS3,PTPN11,IFNA2,JAK1,IFNA10,PTPN1,STAT1,IFNB1
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	0.16099250542651	-1.82639746522706	26	11	0.00340662743883555	3229	10285	56957,10454,9099,7124,7128,23118,329,3551,7185,10616,7186	OTUD7B,TAB1,USP2,TNF,TNFAIP3,TAB2,BIRC2,IKBKB,TRAF1,RBCK1,TRAF2
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.165477183240649	-1.79892195928477	87	32	0.00991018891297615	3229	10285	8870,2246,5525,2252,5295,8503,29851,8823,5296,5290,207,940,5529,8394,79837,8074,2260,5516,3815,4233,2549,8822,118788,941,2255,1839,6714,2248,5518,27006,5781,942	IER3,FGF1,PPP2R5A,FGF7,PIK3R1,PIK3R3,ICOS,FGF16,PIK3R2,PIK3CA,AKT1,CD28,PPP2R5E,PIP5K1A,PIP4K2C,FGF23,FGFR1,PPP2CB,KIT,MET,GAB1,FGF17,PIK3AP1,CD80,FGF10,HBEGF,SRC,FGF3,PPP2R1A,FGF22,PTPN11,CD86
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	0.167685706260155	-1.78566384777394	49	19	0.00588417466707959	3229	10285	22836,8775,51542,9341,9827,9712,79571,51560,5870,9367,51209,10228,9382,8677,8774,60560,122830,8675,90196	RHOBTB3,NAPA,VPS54,VAMP3,RGP1,USP6NL,GCC1,RAB6B,RAB6A,RAB9A,RAB9B,STX6,COG1,STX10,NAPG,NAA35,NAA30,STX16,SYS1
R-HSA-5633007	Regulation of TP53 Activity	0.167716903123686	-1.7854778214119	162	57	0.0176525240012388	3229	10285	94241,1457,6880,7157,5984,890,53615,5932,6233,5985,8550,6119,5810,5983,84289,9219,64769,5564,672,4683,79837,208,10419,5516,10000,207,5928,11073,5608,5571,6749,8851,6882,3622,9099,6879,6881,5518,7314,6794,7311,983,90809,6873,2033,5371,116028,80196,133383,6118,1020,5931,5982,1460,8445,80010,4193	TP53INP1,CSNK2A1,TAF9,TP53,RFC4,CCNA2,MBD3,RBBP8,RPS27A,RFC5,MAPKAPK5,RPA3,RAD1,RFC3,ING5,MTA2,MEAF6,PRKAB1,BRCA1,NBN,PIP4K2C,AKT2,PRMT5,PPP2CB,AKT3,AKT1,RBBP4,TOPBP1,MAP2K6,PRKAG1,SSRP1,CDK5R1,TAF11,ING2,USP2,TAF7,TAF10,PPP2R1A,UBB,STK11,UBA52,CDK1,PIP4P1,TAF2,EP300,PML,RMI2,RNF34,SETD9,RPA2,CDK5,RBBP7,RFC2,CSNK2B,DYRK2,RMI1,MDM2
R-HSA-5654732	Negative regulation of FGFR3 signaling	0.167939626623033	-1.78415072950516	29	12	0.00371632084236606	3229	10285	7314,867,5518,7311,6233,8074,5781,5516,2246,8822,6714,8823	UBB,CBL,PPP2R1A,UBA52,RPS27A,FGF23,PTPN11,PPP2CB,FGF1,FGF17,SRC,FGF16
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	0.167939626623033	-1.78415072950516	29	12	0.00371632084236606	3229	10285	9844,5062,920,375,567,8905,1175,8907,940,919,1173,160	ELMO1,PAK2,CD4,ARF1,B2M,AP1S2,AP2S1,AP1M1,CD28,CD247,AP2M1,AP2A1
R-HSA-2559580	Oxidative Stress Induced Senescence	0.169615404257918	-1.77422173275642	126	45	0.0139362031588727	3229	10285	8342,8970,3725,7295,8348,1032,1019,2353,4193,8350,5931,23043,57690,7314,7311,6015,85236,4343,5606,26523,1021,5928,55766,3014,8726,1911,5602,3015,5608,94239,474382,7867,3013,7029,8345,6233,2146,255626,1031,8334,7157,8331,8335,3456,8550	H2BC14,H2BC11,JUN,TXN,H2BC17,CDKN2D,CDK4,FOS,MDM2,H3C1,RBBP7,TNIK,TNRC6C,UBB,UBA52,RING1,H2BC12,MOV10,MAP2K3,AGO1,CDK6,RBBP4,H2AJ,H2AX,EED,PHC1,MAPK10,H2AZ1,MAP2K6,H2AZ2,H2AB1,MAPKAPK3,H2AC7,TFDP2,H2BC9,RPS27A,EZH2,H2BC1,CDKN2C,H2AC6,TP53,H2AC14,H2AC4,IFNB1,MAPKAPK5
R-HSA-445717	Aquaporin-mediated transport	0.170289692983727	-1.77025421584778	52	20	0.0061938680706101	3229	10285	51764,2782,5567,108,361,2785,2791,2787,59345,2788,2790,8766,360,109,282679,55970,359,54331,2793,2784	GNG13,GNB1,PRKACB,ADCY2,AQP4,GNG3,GNG11,GNG5,GNB4,GNG7,GNG10,RAB11A,AQP3,ADCY3,AQP11,GNG12,AQP2,GNG2,GNGT2,GNB3
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	0.172543653098508	-1.75710501308474	18	8	0.00247754722824404	3229	10285	8823,2248,8074,2252,27006,2246,2255,8822	FGF16,FGF3,FGF23,FGF7,FGF22,FGF1,FGF10,FGF17
R-HSA-5654710	PI-3K cascade:FGFR3	0.172543653098508	-1.75710501308474	18	8	0.00247754722824404	3229	10285	5781,8074,5295,8823,2549,8822,2246,5290	PTPN11,FGF23,PIK3R1,FGF16,GAB1,FGF17,FGF1,PIK3CA
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	0.172543653098508	-1.75710501308474	18	8	0.00247754722824404	3229	10285	8499,5864,6616,6812,8541,6804,10815,6844	PPFIA2,RAB3A,SNAP25,STXBP1,PPFIA3,STX1A,CPLX1,VAMP2
R-HSA-210993	Tie2 Signaling	0.172543653098508	-1.75710501308474	18	8	0.00247754722824404	3229	10285	5290,6464,5296,3265,5295,3845,5781,284	PIK3CA,SHC1,PIK3R2,HRAS,PIK3R1,KRAS,PTPN11,ANGPT1
R-HSA-912631	Regulation of signaling by CBL	0.172543653098508	-1.75710501308474	18	8	0.00247754722824404	3229	10285	6850,867,7525,5290,5296,1399,8503,5295	SYK,CBL,YES1,PIK3CA,PIK3R2,CRKL,PIK3R3,PIK3R1
R-HSA-68962	Activation of the pre-replicative complex	0.173783787675097	-1.749943352003	32	13	0.00402601424589656	3229	10285	54107,4173,8317,5558,6118,4172,4175,84515,6119,23594,23649,5001,56655	POLE3,MCM4,CDC7,PRIM2,RPA2,MCM3,MCM6,MCM8,RPA3,ORC6,POLA2,ORC5,POLE4
R-HSA-167590	Nef Mediated CD4 Down-regulation	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	160,1173,1175,375,920	AP2A1,AP2M1,AP2S1,ARF1,CD4
R-HSA-3785653	Myoclonic epilepsy of Lafora	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	2997,7314,6233,5507,7311	GYS1,UBB,RPS27A,PPP1R3C,UBA52
R-HSA-2465910	MASTL Facilitates Mitotic Progression	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	891,983,5518,5516,10776	CCNB1,CDK1,PPP2R1A,PPP2CB,ARPP19
R-HSA-8853334	Signaling by FGFR3 fusions in cancer	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	5295,3845,5290,2549,3265	PIK3R1,KRAS,PIK3CA,GAB1,HRAS
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	983,891,5001,23594,84515	CDK1,CCNB1,ORC5,ORC6,MCM8
R-HSA-2161522	Abacavir transport and metabolism	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	22978,124,5243,2987,9429	NT5C2,ADH1A,ABCB1,GUK1,ABCG2
R-HSA-3229121	Glycogen storage diseases	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	5507,6233,7311,2997,7314	PPP1R3C,RPS27A,UBA52,GYS1,UBB
R-HSA-8875656	MET receptor recycling	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	2549,4233,5867,382,1399	GAB1,MET,RAB4A,ARF6,CRKL
R-HSA-5663084	Diseases of carbohydrate metabolism	0.175114352496413	-1.74231607562279	10	5	0.00154846701765252	3229	10285	6233,5507,7311,2997,7314	RPS27A,PPP1R3C,UBA52,GYS1,UBB
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.176384774658572	-1.73508745059384	61	23	0.00712294828120161	3229	10285	6850,1072,10109,4690,4620,63916,9844,10810,51517,10787,919,3320,10097,26999,60,2212,998,2209,10094,7410,3326,8976,917	SYK,CFL1,ARPC2,NCK1,MYH2,ELMO2,ELMO1,WASF3,NCKIPSD,NCKAP1,CD247,HSP90AA1,ACTR2,CYFIP2,ACTB,FCGR2A,CDC42,FCGR1A,ARPC3,VAV2,HSP90AB1,WASL,CD3G
R-HSA-6804757	Regulation of TP53 Degradation	0.178734878745072	-1.72185169541949	35	14	0.00433570764942707	3229	10285	208,7157,5516,7314,207,80196,5518,10000,890,7311,6233,983,4193,9099	AKT2,TP53,PPP2CB,UBB,AKT1,RNF34,PPP2R1A,AKT3,CCNA2,UBA52,RPS27A,CDK1,MDM2,USP2
R-HSA-167826	The fatty acid cycling model	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	9016,9481,7351	SLC25A14,SLC25A27,UCP2
R-HSA-5661270	Catabolism of glucuronate to xylulose-5-phosphate	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	6652,51084,10327	SORD,CRYL1,AKR1A1
R-HSA-380095	Tachykinin receptors bind tachykinins	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	6869,6870,6863	TACR1,TACR3,TAC1
R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	6844,6843,9899	VAMP2,VAMP1,SV2B
R-HSA-446205	Synthesis of GDP-mannose	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	29925,5373,29926	GMPPB,PMM2,GMPPA
R-HSA-166187	Mitochondrial Uncoupling Proteins	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	9016,9481,7351	SLC25A14,SLC25A27,UCP2
R-HSA-3065676	SUMO is conjugated to E1 (UBA2:SAE1)	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	6612,6613,7341	SUMO3,SUMO2,SUMO1
R-HSA-167827	The proton buffering model	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	9016,9481,7351	SLC25A14,SLC25A27,UCP2
R-HSA-5683678	Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	6441,653509,6440	SFTPD,SFTPA1,SFTPC
R-HSA-71032	Propionyl-CoA catabolism	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	5096,166785,4594	PCCB,MMAA,MMUT
R-HSA-561048	Organic anion transport	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	9356,116085,9376	SLC22A6,SLC22A12,SLC22A8
R-HSA-8865999	MET activates PTPN11	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	4233,2549,5781	MET,GAB1,PTPN11
R-HSA-111448	Activation of NOXA and translocation to mitochondria	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	7157,5366,7029	TP53,PMAIP1,TFDP2
R-HSA-203641	NOSTRIN mediated eNOS trafficking	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	857,1785,8976	CAV1,DNM2,WASL
R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	9899,6843,6844	SV2B,VAMP1,VAMP2
R-HSA-209931	Serotonin and melatonin biosynthesis	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	15,438,121278	AANAT,ASMT,TPH2
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	3033,3030,35	HADH,HADHA,ACADS
R-HSA-1169092	Activation of RAS in B cells	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	25780,3265,3845	RASGRP3,HRAS,KRAS
R-HSA-2161541	Abacavir metabolism	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	124,22978,2987	ADH1A,NT5C2,GUK1
R-HSA-196819	Vitamin B1 (thiamin) metabolism	0.181971879879068	-1.70390311000161	5	3	0.000929080210591514	3229	10285	79178,80704,10560	THTPA,SLC19A3,SLC19A2
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.18295281808696	-1.69852698404463	38	15	0.00464540105295757	3229	10285	6829,6749,5431,1025,2962,5438,5441,5433,6917,5435,6827,5436,6921,5432,2963	SUPT5H,SSRP1,POLR2B,CDK9,GTF2F1,POLR2I,POLR2L,POLR2D,TCEA1,POLR2F,SUPT4H1,POLR2G,ELOC,POLR2C,GTF2F2
R-HSA-5655302	Signaling by FGFR1 in disease	0.18295281808696	-1.69852698404463	38	15	0.00464540105295757	3229	10285	8805,26127,5295,8822,7750,2246,3265,2549,3845,2260,8074,11160,5290,6772,6776	TRIM24,FGFR1OP2,PIK3R1,FGF17,ZMYM2,FGF1,HRAS,GAB1,KRAS,FGFR1,FGF23,ERLIN2,PIK3CA,STAT1,STAT5A
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.18295281808696	-1.69852698404463	38	15	0.00464540105295757	3229	10285	6827,5432,5436,6921,2963,5435,1025,6829,6917,5431,6749,2962,5441,5438,5433	SUPT4H1,POLR2C,POLR2G,ELOC,GTF2F2,POLR2F,CDK9,SUPT5H,TCEA1,POLR2B,SSRP1,GTF2F1,POLR2L,POLR2I,POLR2D
R-HSA-2022870	Chondroitin sulfate biosynthesis	0.183136556843144	-1.69752319216104	21	9	0.00278724063177454	3229	10285	79586,83539,54480,768213,55454,56548,55790,166012,50515	CHPF,CHST9,CHPF2,MIR671,CSGALNACT2,CHST7,CSGALNACT1,CHST13,CHST11
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.183136556843144	-1.69752319216104	21	9	0.00278724063177454	3229	10285	29883,4848,7157,57472,7832,5325,246175,28984,9337	CNOT7,CNOT2,TP53,CNOT6,BTG2,PLAGL1,CNOT6L,RGCC,CNOT8
R-HSA-1181150	Signaling by NODAL	0.183136556843144	-1.69752319216104	21	9	0.00278724063177454	3229	10285	4089,91,9350,4087,130399,4088,5045,10589,55997	SMAD4,ACVR1B,CER1,SMAD2,ACVR1C,SMAD3,FURIN,DRAP1,CFC1
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	0.183136556843144	-1.69752319216104	21	9	0.00278724063177454	3229	10285	4853,1272,5664,6233,7311,23385,51107,7314,55851	NOTCH2,CNTN1,PSEN2,RPS27A,UBA52,NCSTN,APH1A,UBB,PSENEN
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.183319772239556	-1.69652326176204	79	29	0.00898110870238464	3229	10285	4683,25842,3009,8335,85236,29855,8345,890,4001,8331,7157,5925,8334,3007,255626,3015,3024,7290,1027,3013,474382,94239,1026,8970,8342,8348,3159,3014,55766	NBN,ASF1A,H1-5,H2AC4,H2BC12,UBN1,H2BC9,CCNA2,LMNB1,H2AC14,TP53,RB1,H2AC6,H1-3,H2BC1,H2AZ1,H1-1,HIRA,CDKN1B,H2AC7,H2AB1,H2AZ2,CDKN1A,H2BC11,H2BC14,H2BC17,HMGA1,H2AX,H2AJ
R-HSA-73894	DNA Repair	0.184308780967991	-1.69114277047124	316	107	0.033137194177764	3229	10285	5423,8348,9025,5425,64708,8970,6118,27339,8314,23583,86,80010,6613,548593,5435,80233,5531,5433,5441,2966,9318,7314,5536,221120,1022,7320,85236,3014,7336,2237,27343,3980,5438,2956,125476,79840,51514,7520,10987,3838,56655,10459,8607,5111,328,255626,54890,8345,51138,5887,5984,29844,890,6119,5985,5983,116028,902,51008,8342,5982,2189,57804,8467,60,9636,9768,54107,121642,283899,5436,7311,9656,6917,10038,2140,8554,25898,4331,4255,5431,2033,1069,9031,4968,2968,23030,5432,50813,4350,7341,29086,11073,64421,2071,7334,7157,404672,6233,5932,6612,5810,7329,55775,4683,672,7353	POLB,H2BC17,RNF8,POLD2,COPS7B,H2BC11,RPA2,PRPF19,BAP1,SMUG1,ACTL6A,RMI1,SUMO2,SLX1A,POLR2F,FAAP100,PPP4C,POLR2D,POLR2L,GTF2H2,COPS2,UBB,PPP5C,ALKBH3,CDK7,UBE2B,H2BC12,H2AX,UBE2V2,FEN1,POLL,LIG3,POLR2I,MSH6,INO80C,NHEJ1,DTL,XRCC5,COPS5,KPNA2,POLE4,MAD2L2,RUVBL1,PCNA,APEX1,H2BC1,ALKBH5,H2BC9,COPS4,RAD23B,RFC4,TFPT,CCNA2,RPA3,RFC5,RFC3,RMI2,CCNH,ASCC1,H2BC14,RFC2,FANCG,POLD4,SMARCA5,ACTB,ISG15,PCLAF,POLE3,ALKBH2,INO80E,POLR2G,UBA52,MDC1,TCEA1,PARP2,EYA3,PIAS1,RCHY1,MNAT1,MGMT,POLR2B,EP300,CETN2,BAZ1B,OGG1,GTF2H4,KDM4B,POLR2C,COPS7A,MPG,SUMO1,BABAM1,TOPBP1,DCLRE1C,ERCC3,UBE2N,TP53,GTF2H5,RPS27A,RBBP8,SUMO3,RAD1,UBE2I,TDP1,NBN,BRCA1,UFD1
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.185090270615085	-1.68691162364162	88	32	0.00991018891297615	3229	10285	9440,55090,6837,1024,29079,4790,9314,1387,1019,9370,5468,90390,9412,7480,1959,9439,7124,2167,400569,6604,2033,23389,896,84246,8841,51003,9967,3952,948,55588,9442,5465	MED17,MED9,MED22,CDK8,MED4,NFKB1,KLF4,CREBBP,CDK4,ADIPOQ,PPARG,MED30,MED21,WNT10B,EGR2,MED23,TNF,FABP4,MED11,SMARCD3,EP300,MED13L,CCND3,MED10,HDAC3,MED31,THRAP3,LEP,CD36,MED29,MED27,PPARA
R-HSA-15869	Metabolism of nucleotides	0.186104405633446	-1.6814474421405	97	35	0.0108392691235677	3229	10285	8833,79077,26289,4521,51251,4830,22978,51727,4831,11164,1841,6240,7298,204,7371,159,4833,4860,9583,53343,83549,2745,2876,131870,7372,132,5471,956,56985,2987,1633,7296,1635,79873,7295	GMPS,DCTPP1,AK5,NUDT1,NT5C3A,NME1,NT5C2,CMPK1,NME2,NUDT5,DTYMK,RRM1,TYMS,AK2,UCK2,ADSS2,NME4,PNP,ENTPD4,NUDT9,UCK1,GLRX,GPX1,NUDT16,UMPS,ADK,PPAT,ENTPD3,ADPRM,GUK1,DCK,TXNRD1,DCTD,NUDT18,TXN
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.194615979287722	-1.63672699909816	50	19	0.00588417466707959	3229	10285	79837,5728,5867,51552,9107,5868,4952,5290,84725,5294,8394,3631,5295,8503,3636,375,51763,5296,4534	PIP4K2C,PTEN,RAB4A,RAB14,MTMR6,RAB5A,OCRL,PIK3CA,PLEKHA8,PIK3CG,PIP5K1A,INPP4A,PIK3R1,PIK3R3,INPPL1,ARF1,INPP5K,PIK3R2,MTM1
R-HSA-171007	p38MAPK events	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	7867,3845,5898,6714,5899,3265	MAPKAPK3,KRAS,RALA,SRC,RALB,HRAS
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	7029,5558,23649,5518,5925,5516	TFDP2,PRIM2,POLA2,PPP2R1A,RB1,PPP2CB
R-HSA-1502540	Signaling by Activin	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	130399,4087,4088,10589,4089,91	ACVR1C,SMAD2,SMAD3,DRAP1,SMAD4,ACVR1B
R-HSA-400511	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	1803,60559,9789,28972,5080,23478	DPP4,SPCS3,SPCS2,SPCS1,PAX6,SEC11A
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	830,829,3958,177,6285,3146	CAPZA2,CAPZA1,LGALS3,AGER,S100B,HMGB1
R-HSA-140342	Apoptosis induced DNA fragmentation	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	3024,3836,3146,3009,3007,1676	H1-1,KPNA1,HMGB1,H1-5,H1-3,DFFA
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	6005,3039,51167,760,51706,3043	RHAG,HBA1,CYB5R4,CA2,CYB5R1,HBB
R-HSA-1480926	O2/CO2 exchange in erythrocytes	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	3039,3043,51706,6005,760,51167	HBA1,HBB,CYB5R1,RHAG,CA2,CYB5R4
R-HSA-375281	Hormone ligand-binding receptors	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	170589,3972,7253,114814,2797,2796	GPHA2,LHB,TSHR,GNRHR2,GNRH2,GNRH1
R-HSA-211227	Activation of DNA fragmentation factor	0.195321676937956	-1.63310745423289	13	6	0.00185816042118303	3229	10285	3024,3009,3007,1676,3146,3836	H1-1,H1-5,H1-3,DFFA,HMGB1,KPNA1
R-HSA-194441	Metabolism of non-coding RNA	0.196590337510137	-1.62663322044159	53	20	0.0061938680706101	3229	10285	10762,51808,79023,6634,22916,23636,9972,6628,10419,79084,79760,54960,6635,6606,6632,6633,57122,129401,11097,6637	NUP50,PHAX,NUP37,SNRPD3,NCBP2,NUP62,NUP153,SNRPB,PRMT5,WDR77,GEMIN7,GEMIN8,SNRPE,SMN1,SNRPD1,SNRPD2,NUP107,NUP35,NUP42,SNRPG
R-HSA-191859	snRNP Assembly	0.196590337510137	-1.62663322044159	53	20	0.0061938680706101	3229	10285	9972,23636,6634,22916,79023,10762,51808,6637,129401,11097,57122,6633,6632,6606,79760,6635,54960,79084,10419,6628	NUP153,NUP62,SNRPD3,NCBP2,NUP37,NUP50,PHAX,SNRPG,NUP35,NUP42,NUP107,SNRPD2,SNRPD1,SMN1,GEMIN7,SNRPE,GEMIN8,WDR77,PRMT5,SNRPB
R-HSA-6783589	Interleukin-6 family signaling	0.198355641980442	-1.61769368785643	27	11	0.00340662743883555	3229	10285	5781,1271,5008,3572,6772,867,3717,9021,3592,3569,3716	PTPN11,CNTFR,OSM,IL6ST,STAT1,CBL,JAK2,SOCS3,IL12A,IL6,JAK1
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.201788813418003	-1.6005336066031	137	48	0.0148652833694642	3229	10285	7042,51706,7076,78991,5265,3479,5578,813,948,54863,54676,5478,6647,12,7424,8407,10916,66005,3920,55664,51368,10184,5340,5627,5552,81,967,51571,3309,1072,928,5919,7114,213,23052,7422,1191,7018,7078,7043,6414,29789,54495,5579,10490,29106,7450,10447	TGFB2,CYB5R1,TIMP1,PCYOX1L,SERPINA1,IGF1,PRKCA,CALU,CD36,TOR4A,GTPBP2,PPIA,SOD1,SERPINA3,VEGFC,TAGLN2,MAGED2,CHID1,LAMP2,CDC37L1,TEX264,LHFPL2,PLG,PROS1,SRGN,ACTN4,CD63,CYRIB,HSPA5,CFL1,CD9,RARRES2,TMSB4X,ALB,ENDOD1,VEGFA,CLU,TF,TIMP3,TGFB3,SELENOP,OLA1,TMX3,PRKCB,VTI1B,SCG3,VWF,FAM3C
R-HSA-198203	PI3K/AKT activation	0.203156569779758	-1.59377831752045	128	45	0.0139362031588727	3229	10285	6714,1839,2248,26523,118788,941,2255,8822,4343,942,5781,7157,2931,572,57690,5518,27006,29851,8503,5295,1026,5296,8823,1385,1027,5525,2246,8870,4193,2252,2260,8074,208,79837,5728,2549,5516,4233,3815,940,207,10000,5290,5529,8394	SRC,HBEGF,FGF3,AGO1,PIK3AP1,CD80,FGF10,FGF17,MOV10,CD86,PTPN11,TP53,GSK3A,BAD,TNRC6C,PPP2R1A,FGF22,ICOS,PIK3R3,PIK3R1,CDKN1A,PIK3R2,FGF16,CREB1,CDKN1B,PPP2R5A,FGF1,IER3,MDM2,FGF7,FGFR1,FGF23,AKT2,PIP4K2C,PTEN,GAB1,PPP2CB,MET,KIT,CD28,AKT1,AKT3,PIK3CA,PPP2R5E,PIP5K1A
R-HSA-420092	Glucagon-type ligand receptors	0.203902767202595	-1.59011203012258	30	12	0.00371632084236606	3229	10285	2785,2782,51764,59345,2790,2788,2787,2791,54331,55970,2793,2784	GNG3,GNB1,GNG13,GNB4,GNG10,GNG7,GNG5,GNG11,GNG2,GNG12,GNGT2,GNB3
R-HSA-69473	G2/M DNA damage checkpoint	0.205957292849707	-1.5800864479491	95	34	0.0105295757200372	3229	10285	8345,9656,5932,7533,5984,7157,255626,672,4683,7534,85236,5983,6119,5810,983,5985,9025,8970,8342,6118,7341,3014,7336,8348,7532,116028,2810,80010,7529,891,7334,5982,29086,11073	H2BC9,MDC1,RBBP8,YWHAH,RFC4,TP53,H2BC1,BRCA1,NBN,YWHAZ,H2BC12,RFC3,RPA3,RAD1,CDK1,RFC5,RNF8,H2BC11,H2BC14,RPA2,SUMO1,H2AX,UBE2V2,H2BC17,YWHAG,RMI2,SFN,RMI1,YWHAB,CCNB1,UBE2N,RFC2,BABAM1,TOPBP1
R-HSA-392517	Rap1 signalling	0.209617491426457	-1.56247087855502	16	7	0.00216785382471353	3229	10285	5908,5567,7529,5906,7534,10235,5894	RAP1B,PRKACB,YWHAB,RAP1A,YWHAZ,RASGRP2,RAF1
R-HSA-190242	FGFR1 ligand binding and activation	0.209617491426457	-1.56247087855502	16	7	0.00216785382471353	3229	10285	2248,8074,2260,27006,2255,2246,8822	FGF3,FGF23,FGFR1,FGF22,FGF10,FGF1,FGF17
R-HSA-1834941	STING mediated induction of host immune responses	0.209617491426457	-1.56247087855502	16	7	0.00216785382471353	3229	10285	6737,6778,7520,3428,3661,115004,29110	TRIM21,STAT6,XRCC5,IFI16,IRF3,CGAS,TBK1
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	0.209617491426457	-1.56247087855502	16	7	0.00216785382471353	3229	10285	27006,2246,8822,2255,2248,2260,8074	FGF22,FGF1,FGF17,FGF10,FGF3,FGFR1,FGF23
R-HSA-109582	Hemostasis	0.210353987639417	-1.55896351196143	632	208	0.064416227934345	3229	10285	2785,5906,3512,29127,2771,29106,10242,10490,8503,6414,64805,5138,81,64837,59345,961,6717,3456,5880,50808,1445,1020,4973,3558,6281,3660,9463,8350,51368,5295,3920,2817,5567,5578,10749,7076,54331,6383,7102,80228,6385,10000,2773,23428,11136,7078,2155,3567,388,2159,9371,3446,23657,7450,3560,54495,5547,1072,5770,3309,857,7056,7157,5868,7422,7525,5529,10916,5136,2790,3440,2207,5525,391,5340,998,3447,10235,4778,25942,2782,813,483,5908,80739,5588,5478,2033,7534,50848,3046,6714,54863,3778,1191,208,2776,3716,3661,1437,5579,481,2784,2793,29789,55669,5581,7035,3673,967,5552,23052,3559,914,213,8165,493,26090,5294,57406,8407,1048,10938,5028,7424,7410,4097,4282,3717,5518,3937,462,3479,5265,5781,2788,83692,7042,54676,6546,5269,55970,51317,284,5153,3043,3779,207,5290,7043,7018,3665,9630,3796,3265,2791,5516,2815,10447,1387,120425,5152,5104,90952,5919,3562,3685,928,51571,6566,7114,6464,406974,3797,66005,2983,51764,2787,12,6402,5627,23028,10184,55664,3053,3897,3561,5296,2767,23468,5894,6850,3845,3655,78991,6786,2147,51706,2158,965,4072,6647,30845,2268,3659,830,829,948	GNG3,RAP1A,JCHAIN,RACGAP1,GNAI2,SCG3,KCNMB2,VTI1B,PIK3R3,SELENOP,P2RY12,PDE2A,ACTN4,KLC2,GNB4,CD47,SRI,IFNB1,RAC2,AK3,CSK,CDK5,OLR1,IL2,S100A10,IRF2,PICK1,H3C1,TEX264,PIK3R1,LAMP2,GPC1,PRKACB,PRKCA,KIF1C,TIMP1,GNG2,SDC2,TSPAN7,ORAI2,SDC4,AKT3,GNAI3,SLC7A8,SLC7A9,TIMP3,F7,IL5,RHOB,F10,KIF3B,IFNA10,SLC7A11,VWF,IL2RB,TMX3,PRCP,CFL1,PTPN1,HSPA5,CAV1,THBD,TP53,RAB5A,VEGFA,YES1,PPP2R5E,MAGED2,PDE1A,GNG10,IFNA2,FCER1G,PPP2R5A,RHOG,PLG,CDC42,IFNA13,RASGRP2,NFE2,SIN3A,GNB1,CALU,ATP1B3,RAP1B,MPIG6B,PRKCQ,PPIA,EP300,YWHAZ,F11R,HBE1,SRC,TOR4A,KCNMA1,CLU,AKT2,GNAQ,JAK1,IRF3,CSF2,PRKCB,ATP1B1,GNB3,GNGT2,OLA1,MFN1,PRKCE,TFPI,ITGA2,CD63,SRGN,ENDOD1,IL2RA,CD2,ALB,AKAP1,ATP2B4,ABHD12,PIK3CG,ABHD6,TAGLN2,CEACAM5,EHD1,P2RY1,VEGFC,VAV2,MAFG,MIF,JAK2,PPP2R1A,LCP2,SERPINC1,IGF1,SERPINA1,PTPN11,GNG7,CD99L2,TGFB2,GTPBP2,SLC8A1,SERPINB6,GNG12,PHF21A,ANGPT1,PDE1B,HBB,KCNMB1,AKT1,PIK3CA,TGFB3,TF,IRF7,GNA14,KIF2A,HRAS,GNG11,PPP2CB,GP9,FAM3C,CREBBP,JAML,PDE9A,SERPINA5,ESAM,RARRES2,IL3,ITGAV,CD9,CYRIB,SLC16A1,TMSB4X,SHC1,MIR197,KIF3C,CHID1,GUCY1B1,GNG13,GNG5,SERPINA3,SELL,PROS1,KDM1A,LHFPL2,CDC37L1,SERPIND1,L1CAM,IL2RG,PIK3R2,GNA11,CBX5,RAF1,SYK,KRAS,ITGA6,PCYOX1L,STIM1,F2,CYB5R1,F9,CD58,EPCAM,SOD1,EHD3,FGR,IRF1,CAPZA2,CAPZA1,CD36
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.212248123922024	-1.54999929283081	36	14	0.00433570764942707	3229	10285	6657,4089,27086,9314,5431,27022,5438,5441,5460,5433,5435,4087,5432,5436	SOX2,SMAD4,FOXP1,KLF4,POLR2B,FOXD3,POLR2I,POLR2L,POU5F1,POLR2D,POLR2F,SMAD2,POLR2C,POLR2G
R-HSA-936440	Negative regulators of RIG-I/MDA5 signaling	0.212248123922024	-1.54999929283081	36	14	0.00433570764942707	3229	10285	8887,7323,7311,6233,7314,3093,57506,7321,64135,3661,23586,9636,29110,7128	TAX1BP1,UBE2D3,UBA52,RPS27A,UBB,UBE2K,MAVS,UBE2D1,IFIH1,IRF3,RIGI,ISG15,TBK1,TNFAIP3
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.212248123922024	-1.54999929283081	36	14	0.00433570764942707	3229	10285	9099,4193,983,7314,80196,10000,5518,207,890,7311,6233,208,7157,5516	USP2,MDM2,CDK1,UBB,RNF34,AKT3,PPP2R1A,AKT1,CCNA2,UBA52,RPS27A,AKT2,TP53,PPP2CB
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.215390051379713	-1.5353047020502	39	15	0.00464540105295757	3229	10285	3265,4296,5908,5604,3845,5037,5906,5245,5894,8315,1445,3717,6714,7450,7529	HRAS,MAP3K11,RAP1B,MAP2K1,KRAS,PEBP1,RAP1A,PHB1,RAF1,BRAP,CSK,JAK2,SRC,VWF,YWHAB
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.215390051379713	-1.5353047020502	39	15	0.00464540105295757	3229	10285	5037,5906,5894,5245,1445,8315,5604,3845,3265,5908,4296,7450,7529,6714,3717	PEBP1,RAP1A,RAF1,PHB1,CSK,BRAP,MAP2K1,KRAS,HRAS,RAP1B,MAP3K11,VWF,YWHAB,SRC,JAK2
R-HSA-3928662	EPHB-mediated forward signaling	0.218006750181916	-1.5232292525352	42	16	0.00495509445648808	3229	10285	8976,6714,9475,2051,60,10094,998,6383,7074,6093,3265,10097,10109,1947,1072,7525	WASL,SRC,ROCK2,EPHB6,ACTB,ARPC3,CDC42,SDC2,TIAM1,ROCK1,HRAS,ACTR2,ARPC2,EFNB1,CFL1,YES1
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	5578,8741,7514,8125	PRKCA,TNFSF13,XPO1,ANP32A
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	51094,79602,6794,9370	ADIPOR1,ADIPOR2,STK11,ADIPOQ
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	4087,2280,7048,4088	SMAD2,FKBP1A,TGFBR2,SMAD3
R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	4087,2280,7048,4088	SMAD2,FKBP1A,TGFBR2,SMAD3
R-HSA-174430	Telomere C-strand synthesis initiation	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	23649,5558,54107,56655	POLA2,PRIM2,POLE3,POLE4
R-HSA-68952	DNA replication initiation	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	23649,5558,54107,56655	POLA2,PRIM2,POLE3,POLE4
R-HSA-804914	Transport of fatty acids	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	3933,286256,389812,392399	LCN1,LCN12,LCN15,LCN9
R-HSA-1253288	Downregulation of ERBB4 signaling	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	7311,11059,6233,7314	UBA52,WWP1,RPS27A,UBB
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	4792,3551,4790,4793	NFKBIA,IKBKB,NFKB1,NFKBIB
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	0.22009261116591	-1.51370686136347	8	4	0.00123877361412202	3229	10285	1558,1543,1545,1559	CYP2C8,CYP1A1,CYP1B1,CYP2C9
R-HSA-71403	Citric acid cycle (TCA cycle)	0.22014628837013	-1.51346300647222	19	8	0.00247754722824404	3229	10285	3418,1743,50,6390,3420,6391,3419,8801	IDH2,DLST,ACO2,SDHB,IDH3B,SDHC,IDH3A,SUCLG2
R-HSA-114608	Platelet degranulation	0.220460952681158	-1.51203468512292	132	46	0.0142458965624032	3229	10285	1191,7043,7078,7018,29106,54495,29789,10490,6414,10447,7450,967,51571,81,5552,5919,1072,928,3309,7114,213,23052,7422,8407,12,7424,10916,66005,10184,55664,51368,3920,5340,5627,78991,7076,7042,51706,813,5265,3479,54863,948,54676,5478,6647	CLU,TGFB3,TIMP3,TF,SCG3,TMX3,OLA1,VTI1B,SELENOP,FAM3C,VWF,CD63,CYRIB,ACTN4,SRGN,RARRES2,CFL1,CD9,HSPA5,TMSB4X,ALB,ENDOD1,VEGFA,TAGLN2,SERPINA3,VEGFC,MAGED2,CHID1,LHFPL2,CDC37L1,TEX264,LAMP2,PLG,PROS1,PCYOX1L,TIMP1,TGFB2,CYB5R1,CALU,SERPINA1,IGF1,TOR4A,CD36,GTPBP2,PPIA,SOD1
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	0.221997774566845	-1.50508792163377	48	18	0.00557448126354909	3229	10285	2051,7410,7074,55851,1944,4318,23385,1969,6714,5664,2043,1947,1173,160,51107,7525,1946,1175	EPHB6,VAV2,TIAM1,PSENEN,EFNA3,MMP9,NCSTN,EPHA2,SRC,PSEN2,EPHA4,EFNB1,AP2M1,AP2A1,APH1A,YES1,EFNA5,AP2S1
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.227771808975785	-1.4794109890258	90	32	0.00991018891297615	3229	10285	940,207,10000,5290,2549,3815,4233,2260,208,8074,4193,2252,1027,2246,5296,8823,1385,29851,8503,5295,1026,27006,2931,572,942,5781,2255,118788,8822,941,2248,1839	CD28,AKT1,AKT3,PIK3CA,GAB1,KIT,MET,FGFR1,AKT2,FGF23,MDM2,FGF7,CDKN1B,FGF1,PIK3R2,FGF16,CREB1,ICOS,PIK3R3,PIK3R1,CDKN1A,FGF22,GSK3A,BAD,CD86,PTPN11,FGF10,PIK3AP1,FGF17,CD80,FGF3,HBEGF
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.227771808975785	-1.4794109890258	90	32	0.00991018891297615	3229	10285	22919,203068,23291,3320,7532,55142,11258,80321,7846,4751,1781,7283,891,8636,54820,6233,4659,7311,10133,5518,5500,7314,8655,95681,10121,619553,5048,1069,10383,1454,6500,983	MAPRE1,TUBB,FBXW11,HSP90AA1,YWHAG,HAUS2,DCTN3,CEP70,TUBA1A,NEK2,DYNC1I2,TUBG1,CCNB1,SSNA1,NDE1,RPS27A,PPP1R12A,UBA52,OPTN,PPP2R1A,PPP1CB,UBB,DYNLL1,CEP41,ACTR1A,MIR484,PAFAH1B1,CETN2,TUBB4B,CSNK1E,SKP1,CDK1
R-HSA-6806834	Signaling by MET	0.227996723921946	-1.47842401889432	69	25	0.00774233508826262	3229	10285	5906,5290,2549,3265,4233,10653,5867,3913,382,1399,5295,5770,7311,3673,6233,7314,867,5908,5781,3845,57610,9146,6464,9101,6714	RAP1A,PIK3CA,GAB1,HRAS,MET,SPINT2,RAB4A,LAMB2,ARF6,CRKL,PIK3R1,PTPN1,UBA52,ITGA2,RPS27A,UBB,CBL,RAP1B,PTPN11,KRAS,RANBP10,HGS,SHC1,USP8,SRC
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	0.228118013409307	-1.47789218126536	22	9	0.00278724063177454	3229	10285	5096,166785,27349,35,3033,4706,4594,3030,10449	PCCB,MMAA,MCAT,ACADS,HADH,NDUFAB1,MMUT,HADHA,ACAA2
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	0.228118013409307	-1.47789218126536	22	9	0.00278724063177454	3229	10285	8823,2549,3265,3845,5295,8074,8822,5290,2246	FGF16,GAB1,HRAS,KRAS,PIK3R1,FGF23,FGF17,PIK3CA,FGF1
R-HSA-166208	mTORC1-mediated signalling	0.228118013409307	-1.47789218126536	22	9	0.00278724063177454	3229	10285	1975,8649,28956,6009,55004,10325,7529,1977,10670	EIF4B,LAMTOR3,LAMTOR2,RHEB,LAMTOR1,RRAGB,YWHAB,EIF4E,RRAGA
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.228118013409307	-1.47789218126536	22	9	0.00278724063177454	3229	10285	920,567,1175,375,8905,8907,940,1173,160	CD4,B2M,AP2S1,ARF1,AP1S2,AP1M1,CD28,AP2M1,AP2A1
R-HSA-69273	Cyclin A/B1 associated events during G2/M transition	0.228118013409307	-1.47789218126536	22	9	0.00278724063177454	3229	10285	902,983,1022,5516,7514,5518,890,891,4331	CCNH,CDK1,CDK7,PPP2CB,XPO1,PPP2R1A,CCNA2,CCNB1,MNAT1
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	0.228118013409307	-1.47789218126536	22	9	0.00278724063177454	3229	10285	2147,3053,2158,5104,462,7450,2815,5547,2159	F2,SERPIND1,F9,SERPINA5,SERPINC1,VWF,GP9,PRCP,F10
R-HSA-5655332	Signaling by FGFR3 in disease	0.228118013409307	-1.47789218126536	22	9	0.00278724063177454	3229	10285	2246,5290,8822,8823,3265,2549,3845,5295,8074	FGF1,PIK3CA,FGF17,FGF16,HRAS,GAB1,KRAS,PIK3R1,FGF23
R-HSA-73927	Depurination	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	4968,4350	OGG1,MPG
R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	292,291	SLC25A5,SLC25A4
R-HSA-5624958	ARL13B-mediated ciliary trafficking of INPP5E	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	5147,56623	PDE6D,INPP5E
R-HSA-191647	c-src mediated regulation of Cx43 function and closure of gap junctions	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	6714,2697	SRC,GJA1
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	5460,6657	POU5F1,SOX2
R-HSA-351200	Interconversion of polyamines	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	196743,6303	PAOX,SAT1
R-HSA-5653890	Lactose synthesis	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	6513,2683	SLC2A1,B4GALT1
R-HSA-77108	Utilization of Ketone Bodies	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	5019,38	OXCT1,ACAT1
R-HSA-177539	Autointegration results in viral DNA circles	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	8815,3159	BANF1,HMGA1
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	8074,2260	FGF23,FGFR1
R-HSA-964975	Vitamins B6 activation to pyridoxal phosphate	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	55163,316	PNPO,AOX1
R-HSA-5250958	Toxicity of botulinum toxin type B (BoNT/B)	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	127833,6844	SYT2,VAMP2
R-HSA-844455	The NLRP1 inflammasome	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	598,22861	BCL2L1,NLRP1
R-HSA-170145	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	890,983	CCNA2,CDK1
R-HSA-110331	Cleavage of the damaged purine	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	4350,4968	MPG,OGG1
R-HSA-5602571	TRAF3 deficiency - HSE	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	148022,7098	TICAM1,TLR3
R-HSA-191650	Regulation of gap junction activity	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	6714,2697	SRC,GJA1
R-HSA-3249367	STAT6-mediated induction of chemokines	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	6778,29110	STAT6,TBK1
R-HSA-352238	Breakdown of the nuclear lamina	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	4000,4001	LMNA,LMNB1
R-HSA-5250971	Toxicity of botulinum toxin type C (BoNT/C)	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	6616,6804	SNAP25,STX1A
R-HSA-8853336	Signaling by plasma membrane FGFR1 fusions	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	11160,2260	ERLIN2,FGFR1
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	4968,4350	OGG1,MPG
R-HSA-5250989	Toxicity of botulinum toxin type G (BoNT/G)	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	6844,6843	VAMP2,VAMP1
R-HSA-5250992	Toxicity of botulinum toxin type E (BoNT/E)	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	9899,6616	SV2B,SNAP25
R-HSA-175567	Integration of viral DNA into host genomic DNA	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	3159,8815	HMGA1,BANF1
R-HSA-6806664	Metabolism of vitamin K	0.23378475828779	-1.45335442331049	3	2	0.00061938680706101	3229	10285	154807,29914	VKORC1L1,UBIAD1
R-HSA-389661	Glyoxylate metabolism and glycine degradation	0.234270574192561	-1.45127853165614	25	10	0.00309693403530505	3229	10285	387787,27232,275,11019,1629,5162,5160,4706,1743,1737	LIPT2,GNMT,AMT,LIAS,DBT,PDHB,PDHA1,NDUFAB1,DLST,DLAT
R-HSA-1251985	Nuclear signaling by ERBB4	0.234270574192561	-1.45127853165614	25	10	0.00309693403530505	3229	10285	55851,6285,6387,51107,23385,6776,5664,1839,5241,23118	PSENEN,S100B,CXCL12,APH1A,NCSTN,STAT5A,PSEN2,HBEGF,PGR,TAB2
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	0.239081302278671	-1.43095160799947	28	11	0.00340662743883555	3229	10285	5564,6009,5571,10670,55004,6794,10325,8649,28956,55437,51719	PRKAB1,RHEB,PRKAG1,RRAGA,LAMTOR1,STK11,RRAGB,LAMTOR3,LAMTOR2,STRADB,CAB39
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.239081302278671	-1.43095160799947	28	11	0.00340662743883555	3229	10285	10302,6618,6617,171568,5441,10621,51082,55703,6619,84265,5435	SNAPC5,SNAPC2,SNAPC1,POLR3H,POLR2L,POLR3F,POLR1D,POLR3B,SNAPC3,POLR3GL,POLR2F
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.241905334021035	-1.41920881108824	11	5	0.00154846701765252	3229	10285	2237,4683,5932,3980,10038	FEN1,NBN,RBBP8,LIG3,PARP2
R-HSA-2514853	Condensation of Prometaphase Chromosomes	0.241905334021035	-1.41920881108824	11	5	0.00154846701765252	3229	10285	1460,10051,1457,891,983	CSNK2B,SMC4,CSNK2A1,CCNB1,CDK1
R-HSA-8851805	MET activates RAS signaling	0.241905334021035	-1.41920881108824	11	5	0.00154846701765252	3229	10285	3265,6464,4233,3845,57610	HRAS,SHC1,MET,KRAS,RANBP10
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	0.241905334021035	-1.41920881108824	11	5	0.00154846701765252	3229	10285	7311,6233,7314,7251,51160	UBA52,RPS27A,UBB,TSG101,VPS28
R-HSA-174490	Membrane binding and targetting of GAG proteins	0.241905334021035	-1.41920881108824	11	5	0.00154846701765252	3229	10285	51160,7251,7314,6233,7311	VPS28,TSG101,UBB,RPS27A,UBA52
R-HSA-5655291	Signaling by FGFR4 in disease	0.241905334021035	-1.41920881108824	11	5	0.00154846701765252	3229	10285	2549,3265,3845,5290,5295	GAB1,HRAS,KRAS,PIK3CA,PIK3R1
R-HSA-8875555	MET activates RAP1 and RAC1	0.241905334021035	-1.41920881108824	11	5	0.00154846701765252	3229	10285	5906,1399,5908,4233,2549	RAP1A,CRKL,RAP1B,MET,GAB1
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.242873526021006	-1.41521444018198	31	12	0.00371632084236606	3229	10285	5516,4208,3725,4205,5518,466,2002,1385,1845,5602,2353,1848	PPP2CB,MEF2C,JUN,MEF2A,PPP2R1A,ATF1,ELK1,CREB1,DUSP3,MAPK10,FOS,DUSP6
R-HSA-1839124	FGFR1 mutant receptor activation	0.242873526021006	-1.41521444018198	31	12	0.00371632084236606	3229	10285	6776,6772,5290,11160,8074,2260,8822,2246,7750,26127,5295,8805	STAT5A,STAT1,PIK3CA,ERLIN2,FGF23,FGFR1,FGF17,FGF1,ZMYM2,FGFR1OP2,PIK3R1,TRIM24
R-HSA-5654733	Negative regulation of FGFR4 signaling	0.242873526021006	-1.41521444018198	31	12	0.00371632084236606	3229	10285	5516,5781,8074,6233,7311,867,5518,7314,8823,6714,8822,2246	PPP2CB,PTPN11,FGF23,RPS27A,UBA52,CBL,PPP2R1A,UBB,FGF16,SRC,FGF17,FGF1
R-HSA-2022928	HS-GAG biosynthesis	0.242873526021006	-1.41521444018198	31	12	0.00371632084236606	3229	10285	9348,2239,6383,9955,222537,2817,3340,6385,2131,26035,9957,9653	NDST3,GPC4,SDC2,HS3ST3A1,HS3ST5,GPC1,NDST1,SDC4,EXT1,GLCE,HS3ST1,HS2ST1
R-HSA-113510	E2F mediated regulation of DNA replication	0.245874509049108	-1.40293399902485	34	13	0.00402601424589656	3229	10285	23649,7298,5518,5001,891,5558,7029,84515,5111,5925,23594,5516,983	POLA2,TYMS,PPP2R1A,ORC5,CCNB1,PRIM2,TFDP2,MCM8,PCNA,RB1,ORC6,PPP2CB,CDK1
R-HSA-176187	Activation of ATR in response to replication stress	0.248248912949946	-1.39332335491862	37	14	0.00433570764942707	3229	10285	4173,8317,4175,6118,4172,5984,23594,5982,84515,5810,6119,5985,5001,5983	MCM4,CDC7,MCM6,RPA2,MCM3,RFC4,ORC6,RFC2,MCM8,RAD1,RPA3,RFC5,ORC5,RFC3
R-HSA-167287	HIV elongation arrest and recovery	0.250119102157982	-1.38581806593452	40	15	0.00464540105295757	3229	10285	1025,6749,5431,6829,5435,2963,6827,6921,5436,5432,5438,5441,5433,2962,6917	CDK9,SSRP1,POLR2B,SUPT5H,POLR2F,GTF2F2,SUPT4H1,ELOC,POLR2G,POLR2C,POLR2I,POLR2L,POLR2D,GTF2F1,TCEA1
R-HSA-167290	Pausing and recovery of HIV elongation	0.250119102157982	-1.38581806593452	40	15	0.00464540105295757	3229	10285	2963,6921,5432,5436,6827,5435,6917,5433,5441,5438,2962,1025,6749,5431,6829	GTF2F2,ELOC,POLR2C,POLR2G,SUPT4H1,POLR2F,TCEA1,POLR2D,POLR2L,POLR2I,GTF2F1,CDK9,SSRP1,POLR2B,SUPT5H
R-HSA-168325	Viral Messenger RNA Synthesis	0.251577981511183	-1.38000227185194	43	16	0.00495509445648808	3229	10285	9972,23636,5431,79023,10762,2962,5433,11097,5438,129401,5441,57122,5435,5432,5436,2963	NUP153,NUP62,POLR2B,NUP37,NUP50,GTF2F1,POLR2D,NUP42,POLR2I,NUP35,POLR2L,NUP107,POLR2F,POLR2C,POLR2G,GTF2F2
R-HSA-5362517	Signaling by Retinoic Acid	0.251577981511183	-1.38000227185194	43	16	0.00495509445648808	3229	10285	1737,195814,2171,51109,1382,157506,5162,10901,9249,6258,1375,124,728635,220,1592,5160	DLAT,SDR16C5,FABP5,RDH11,CRABP2,RDH10,PDHB,DHRS4,DHRS3,RXRG,CPT1B,ADH1A,DHRS4L1,ALDH1A3,CYP26A1,PDHA1
R-HSA-71406	Pyruvate metabolism and Citric Acid (TCA) cycle	0.253533814229625	-1.37225807538051	49	18	0.00557448126354909	3229	10285	3418,1737,51660,3939,3945,6566,6390,3420,5162,6391,1743,50,5160,2739,92483,57546,8801,3419	IDH2,DLAT,MPC1,LDHA,LDHB,SLC16A1,SDHB,IDH3B,PDHB,SDHC,DLST,ACO2,PDHA1,GLO1,LDHAL6B,PDP2,SUCLG2,IDH3A
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.253604597723347	-1.37197892675948	76	27	0.00836172189532363	3229	10285	1974,7334,3838,3661,9636,3716,4600,10762,5610,9775,79023,5495,57122,6772,11097,1977,4599,23586,23636,9972,3836,317649,7314,9470,7311,129401,6233	EIF4A2,UBE2N,KPNA2,IRF3,ISG15,JAK1,MX2,NUP50,EIF2AK2,EIF4A3,NUP37,PPM1B,NUP107,STAT1,NUP42,EIF4E,MX1,RIGI,NUP62,NUP153,KPNA1,EIF4E3,UBB,EIF4E2,UBA52,NUP35,RPS27A
R-HSA-1169408	ISG15 antiviral mechanism	0.253604597723347	-1.37197892675948	76	27	0.00836172189532363	3229	10285	11097,1977,6772,57122,5495,9775,79023,10762,5610,4600,3661,3838,9636,3716,1974,7334,129401,7311,6233,7314,9470,317649,3836,23586,23636,9972,4599	NUP42,EIF4E,STAT1,NUP107,PPM1B,EIF4A3,NUP37,NUP50,EIF2AK2,MX2,IRF3,KPNA2,ISG15,JAK1,EIF4A2,UBE2N,NUP35,UBA52,RPS27A,UBB,EIF4E2,EIF4E3,KPNA1,RIGI,NUP62,NUP153,MX1
R-HSA-5693606	DNA Double Strand Break Response	0.253604597723347	-1.37197892675948	76	27	0.00836172189532363	3229	10285	7329,4683,672,85236,9031,5536,2140,8345,7311,9656,6233,7314,7157,255626,3838,7334,29086,8314,8467,9025,8970,8342,7341,3014,7336,8348,23030	UBE2I,NBN,BRCA1,H2BC12,BAZ1B,PPP5C,EYA3,H2BC9,UBA52,MDC1,RPS27A,UBB,TP53,H2BC1,KPNA2,UBE2N,BABAM1,BAP1,SMARCA5,RNF8,H2BC11,H2BC14,SUMO1,H2AX,UBE2V2,H2BC17,KDM4B
R-HSA-2980766	Nuclear Envelope Breakdown	0.254132214920504	-1.36990061620987	52	19	0.00588417466707959	3229	10285	140609,8815,57122,91754,7443,4001,5578,7112,11097,4000,129401,10762,5579,983,79023,891,23592,9972,23636	NEK7,BANF1,NUP107,NEK9,VRK1,LMNB1,PRKCA,TMPO,NUP42,LMNA,NUP35,NUP50,PRKCB,CDK1,NUP37,CCNB1,LEMD3,NUP153,NUP62
R-HSA-421270	Cell-cell junction organization	0.254830281875856	-1.36715751667909	61	22	0.00681325487767111	3229	10285	9074,1009,1012,92359,3728,53842,5010,50855,23562,9069,9080,1364,1499,5819,9073,1365,1006,1005,50848,1500,1495,9076	CLDN6,CDH11,CDH13,CRB3,JUP,CLDN22,CLDN11,PARD6A,CLDN14,CLDN12,CLDN9,CLDN4,CTNNB1,NECTIN2,CLDN8,CLDN3,CDH8,CDH7,F11R,CTNND1,CTNNA1,CLDN1
R-HSA-428540	Activation of Rac	0.25581352857457	-1.36330650392325	14	6	0.00185816042118303	3229	10285	56924,2817,5062,6655,4690,57144	PAK6,GPC1,PAK2,SOS2,NCK1,PAK5
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	0.25581352857457	-1.36330650392325	14	6	0.00185816042118303	3229	10285	5861,81876,983,26003,891,5862	RAB1A,RAB1B,CDK1,GORASP2,CCNB1,RAB2A
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.25581352857457	-1.36330650392325	14	6	0.00185816042118303	3229	10285	2956,5425,6118,6119,5111,57804	MSH6,POLD2,RPA2,RPA3,PCNA,POLD4
R-HSA-622312	Inflammasomes	0.26524140501099	-1.32711490536464	17	7	0.00216785382471353	3229	10285	29108,598,22861,114548,10628,3326,7295	PYCARD,BCL2L1,NLRP1,NLRP3,TXNIP,HSP90AB1,TXN
R-HSA-3296482	Defects in vitamin and cofactor metabolism	0.26524140501099	-1.32711490536464	17	7	0.00216785382471353	3229	10285	5091,4594,5096,166785,25974,27249,31	PC,MMUT,PCCB,MMAA,MMACHC,MMADHC,ACACA
R-HSA-5627117	RHO GTPases Activate ROCKs	0.26524140501099	-1.32711490536464	17	7	0.00216785382471353	3229	10285	103910,9475,388,4637,6093,5500,4659	MYL12B,ROCK2,RHOB,MYL6,ROCK1,PPP1CB,PPP1R12A
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	0.271869214734247	-1.302434156504	20	8	0.00247754722824404	3229	10285	7189,7335,5608,7867,23118,7334,5606,10454	TRAF6,UBE2V1,MAP2K6,MAPKAPK3,TAB2,UBE2N,MAP2K3,TAB1
R-HSA-5654720	PI-3K cascade:FGFR4	0.271869214734247	-1.302434156504	20	8	0.00247754722824404	3229	10285	5290,2246,8822,2549,8823,5781,8074,5295	PIK3CA,FGF1,FGF17,GAB1,FGF16,PTPN11,FGF23,PIK3R1
R-HSA-5654706	FRS-mediated FGFR3 signaling	0.271869214734247	-1.302434156504	20	8	0.00247754722824404	3229	10285	8822,2246,3265,8823,10817,8074,5781,3845	FGF17,FGF1,HRAS,FGF16,FRS3,FGF23,PTPN11,KRAS
R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.271869214734247	-1.302434156504	20	8	0.00247754722824404	3229	10285	7157,10419,4193,7311,6233,7314,2033,133383	TP53,PRMT5,MDM2,UBA52,RPS27A,UBB,EP300,SETD9
R-HSA-3371556	Cellular response to heat stress	0.275683672033705	-1.2885011863779	89	31	0.00960049550944565	3229	10285	9531,10013,11097,51182,6118,3320,57122,6767,1915,6782,27000,2288,1387,3326,79023,57805,10049,10762,818,129401,3309,3312,23636,9972,7266,2033,51501,3281,6119,9532,10728	BAG3,HDAC6,NUP42,HSPA14,RPA2,HSP90AA1,NUP107,ST13,EEF1A1,HSPA13,DNAJC2,FKBP4,CREBBP,HSP90AB1,NUP37,CCAR2,DNAJB6,NUP50,CAMK2G,NUP35,HSPA5,HSPA8,NUP62,NUP153,DNAJC7,EP300,HIKESHI,HSBP1,RPA3,BAG2,PTGES3
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.276625806794248	-1.28508956405215	23	9	0.00278724063177454	3229	10285	4088,60436,7323,4087,7321,7314,7311,4089,6233	SMAD3,TGIF2,UBE2D3,SMAD2,UBE2D1,UBB,UBA52,SMAD4,RPS27A
R-HSA-5365859	RA biosynthesis pathway	0.276625806794248	-1.28508956405215	23	9	0.00278724063177454	3229	10285	157506,9249,10901,124,1592,728635,220,195814,51109	RDH10,DHRS3,DHRS4,ADH1A,CYP26A1,DHRS4L1,ALDH1A3,SDR16C5,RDH11
R-HSA-3371571	HSF1-dependent transactivation	0.276625806794248	-1.28508956405215	23	9	0.00278724063177454	3229	10285	1387,2033,3320,2288,3312,10728,818,3326,3281	CREBBP,EP300,HSP90AA1,FKBP4,HSPA8,PTGES3,CAMK2G,HSP90AB1,HSBP1
R-HSA-210991	Basigin interactions	0.280069367165451	-1.27271796661873	26	10	0.00309693403530505	3229	10285	5478,23428,11136,6566,23657,3655,483,857,481,3897	PPIA,SLC7A8,SLC7A9,SLC16A1,SLC7A11,ITGA6,ATP1B3,CAV1,ATP1B1,L1CAM
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	2879,2877,2876	GPX4,GPX2,GPX1
R-HSA-189483	Heme degradation	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	644,54658,3163	BLVRA,UGT1A1,HMOX2
R-HSA-8849470	PTK6 Regulates Cell Cycle	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	1027,595,1019	CDKN1B,CCND1,CDK4
R-HSA-3371599	Defective HLCS causes multiple carboxylase deficiency	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	31,5091,5096	ACACA,PC,PCCB
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	2876,2879,2877	GPX1,GPX4,GPX2
R-HSA-500753	Pyrimidine biosynthesis	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	1635,7372,7298	DCTD,UMPS,TYMS
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	4087,7048,4088	SMAD2,TGFBR2,SMAD3
R-HSA-193993	Mineralocorticoid biosynthesis	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	1589,3972,1585	CYP21A2,LHB,CYP11B2
R-HSA-5660668	CLEC7A/inflammasome pathway	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	4790,29108,3553	NFKB1,PYCARD,IL1B
R-HSA-3323169	Defects in biotin (Btn) metabolism	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	5091,5096,31	PC,PCCB,ACACA
R-HSA-211916	Vitamins	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	1594,120227,1592	CYP27B1,CYP2R1,CYP26A1
R-HSA-390247	Beta-oxidation of very long chain fatty acids	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	51,10005,1384	ACOX1,ACOT8,CRAT
R-HSA-6782861	Synthesis of wybutosine at G37 of tRNA(Phe)	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	129450,57570,127253	TYW5,TRMT5,TYW3
R-HSA-5676934	Protein repair	0.281902667142058	-1.26619341960119	6	3	0.000929080210591514	3229	10285	51734,7295,253827	MSRB1,TXN,MSRB3
R-HSA-390918	Peroxisomal lipid metabolism	0.282556770738755	-1.2638757902178	29	11	0.00340662743883555	3229	10285	10478,3417,10005,8443,5264,51,283927,390916,1384,23600,1962	SLC25A17,IDH1,ACOT8,GNPAT,PHYH,ACOX1,NUDT7,NUDT19,CRAT,AMACR,EHHADH
R-HSA-5218920	VEGFR2 mediated vascular permeability	0.282556770738755	-1.2638757902178	29	11	0.00340662743883555	3229	10285	3728,10000,207,3320,1499,208,857,7410,5062,1500,1495	JUP,AKT3,AKT1,HSP90AA1,CTNNB1,AKT2,CAV1,VAV2,PAK2,CTNND1,CTNNA1
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.282803418788336	-1.26300325596512	68	24	0.00743264168473212	3229	10285	1594,1562,5447,285440,1585,120227,1577,1586,1584,1593,1559,1581,66002,1589,11283,64816,1545,1572,1565,1543,126410,1558,51302,1592	CYP27B1,CYP2C18,POR,CYP4V2,CYP11B2,CYP2R1,CYP3A5,CYP17A1,CYP11B1,CYP27A1,CYP2C9,CYP7A1,CYP4F12,CYP21A2,CYP4F8,CYP3A43,CYP1B1,CYP2F1,CYP2D6,CYP1A1,CYP4F22,CYP2C8,CYP39A1,CYP26A1
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.283654918019451	-1.2599968570223	65	23	0.00712294828120161	3229	10285	4233,3815,2549,8074,2260,940,5290,8823,5296,5295,29851,8503,2252,2246,942,5781,27006,2248,1839,118788,2255,8822,941	MET,KIT,GAB1,FGF23,FGFR1,CD28,PIK3CA,FGF16,PIK3R2,PIK3R1,ICOS,PIK3R3,FGF7,FGF1,CD86,PTPN11,FGF22,FGF3,HBEGF,PIK3AP1,FGF10,FGF17,CD80
R-HSA-4791275	Signaling by WNT in cancer	0.285547926952717	-1.25334539373751	35	13	0.00402601424589656	3229	10285	22943,8322,5525,80351,8323,4040,1499,5516,5518,1452,8658,1487,5529	DKK1,FZD4,PPP2R5A,TNKS2,FZD6,LRP6,CTNNB1,PPP2CB,PPP2R1A,CSNK1A1,TNKS,CTBP1,PPP2R5E
R-HSA-75153	Apoptotic execution  phase	0.286287969948041	-1.25075708680371	53	19	0.00588417466707959	3229	10285	3007,118,5588,1499,4001,8428,4000,51765,6709,5062,1676,3146,6304,3836,329,3009,6093,2620,3024	H1-3,ADD1,PRKCQ,CTNNB1,LMNB1,STK24,LMNA,STK26,SPTAN1,PAK2,DFFA,HMGB1,SATB1,KPNA1,BIRC2,H1-5,ROCK1,GAS2,H1-1
R-HSA-5668914	Diseases of metabolism	0.286960314600399	-1.24841134943727	44	16	0.00495509445648808	3229	10285	7314,7311,5096,6233,31,2997,166785,5507,6440,3417,27249,25974,6441,653509,4594,5091	UBB,UBA52,PCCB,RPS27A,ACACA,GYS1,MMAA,PPP1R3C,SFTPC,IDH1,MMADHC,MMACHC,SFTPD,SFTPA1,MMUT,PC
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.286960314600399	-1.24841134943727	44	16	0.00495509445648808	3229	10285	2810,208,581,8655,5366,7157,7532,572,7029,7533,10000,207,578,7534,7529,598	SFN,AKT2,BAX,DYNLL1,PMAIP1,TP53,YWHAG,BAD,TFDP2,YWHAH,AKT3,AKT1,BAK1,YWHAZ,YWHAB,BCL2L1
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.286960314600399	-1.24841134943727	44	16	0.00495509445648808	3229	10285	165679,55331,259230,5007,166929,56848,94103,9217,94101,2531,253782,29956,171546,8560,79152,23683	SPTSSB,ACER3,SGMS1,OSBP,SGMS2,SPHK2,ORMDL3,VAPB,ORMDL1,KDSR,CERS6,CERS2,SPTSSA,DEGS1,FA2H,PRKD3
R-HSA-212165	Epigenetic regulation of gene expression	0.28989757653361	-1.23822760275277	151	51	0.0157943635800557	3229	10285	9219,8335,8334,255626,29115,8331,7913,53615,2146,404672,8345,94239,6839,474382,79685,3013,2071,3015,57504,55766,2968,3014,8726,10284,5928,11335,1022,9031,85236,2033,51082,4331,79101,5435,23451,5252,25942,2966,5441,30834,84172,8350,8467,5931,8819,100302240,60,902,8348,8342,8970	MTA2,H2AC4,H2AC6,H2BC1,SAP30BP,H2AC14,DEK,MBD3,EZH2,GTF2H5,H2BC9,H2AZ2,SUV39H1,H2AB1,SAP30L,H2AC7,ERCC3,H2AZ1,MTA3,H2AJ,GTF2H4,H2AX,EED,SAP18,RBBP4,CBX3,CDK7,BAZ1B,H2BC12,EP300,POLR1D,MNAT1,TAF1D,POLR2F,SF3B1,PHF1,SIN3A,GTF2H2,POLR2L,POLR1H,POLR1B,H3C1,SMARCA5,RBBP7,SAP30,MIR1304,ACTB,CCNH,H2BC17,H2BC14,H2BC11
R-HSA-1500931	Cell-Cell communication	0.300064163657138	-1.20375894833763	133	45	0.0139362031588727	3229	10285	8573,961,1499,81,9069,9459,5010,10979,1012,3728,1495,3611,50855,9074,5290,8976,9076,977,9073,8935,7016,3655,5781,1364,1009,92359,53842,6711,6714,100126326,1005,4690,50848,5819,1365,1006,23607,7305,9080,6709,23562,5296,5295,1500,55679	CASK,CD47,CTNNB1,ACTN4,CLDN12,ARHGEF6,CLDN11,FERMT2,CDH13,JUP,CTNNA1,ILK,PARD6A,CLDN6,PIK3CA,WASL,CLDN1,CD151,CLDN8,SKAP2,TESK1,ITGA6,PTPN11,CLDN4,CDH11,CRB3,CLDN22,SPTBN1,SRC,MIR936,CDH7,NCK1,F11R,NECTIN2,CLDN3,CDH8,CD2AP,TYROBP,CLDN9,SPTAN1,CLDN14,PIK3R2,PIK3R1,CTNND1,LIMS2
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	241,2876,2879,2877	ALOX5AP,GPX1,GPX4,GPX2
R-HSA-391908	Prostanoid ligand receptors	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	5734,5737,5732,5731	PTGER4,PTGFR,PTGER2,PTGER1
R-HSA-75094	Formation of the Editosome	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	164668,27350,9582,200315	APOBEC3H,APOBEC3C,APOBEC3B,APOBEC3A
R-HSA-72200	mRNA Editing: C to U Conversion	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	164668,9582,27350,200315	APOBEC3H,APOBEC3B,APOBEC3C,APOBEC3A
R-HSA-5666185	RHO GTPases Activate Rhotekin and Rhophilins	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	30851,388,6242,64130	TAX1BP3,RHOB,RTKN,LIN7B
R-HSA-110357	Displacement of DNA glycosylase by APEX1	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	23583,4350,328,4968	SMUG1,MPG,APEX1,OGG1
R-HSA-2179392	EGFR Transactivation by Gastrin	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	3845,1839,5578,3265	KRAS,HBEGF,PRKCA,HRAS
R-HSA-390696	Adrenoceptors	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	148,153,155,154	ADRA1A,ADRB1,ADRB3,ADRB2
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	1558,1545,1559,1543	CYP2C8,CYP1B1,CYP2C9,CYP1A1
R-HSA-1614558	Degradation of cysteine and homocysteine	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	7263,1468,84890,1036	TST,SLC25A10,ADO,CDO1
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	208,10000,207,1385	AKT2,AKT3,AKT1,CREB1
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	0.302793856723347	-1.19470304585667	9	4	0.00123877361412202	3229	10285	760,6005,3039,3043	CA2,RHAG,HBA1,HBB
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.30884999312064	-1.17489957911434	75	26	0.00805202849179312	3229	10285	85236,9031,7329,4683,672,2140,5536,7314,7311,8345,6233,9656,255626,7157,7334,29086,8314,8467,8970,8342,7341,9025,23030,7336,3014,8348	H2BC12,BAZ1B,UBE2I,NBN,BRCA1,EYA3,PPP5C,UBB,UBA52,H2BC9,RPS27A,MDC1,H2BC1,TP53,UBE2N,BABAM1,BAP1,SMARCA5,H2BC11,H2BC14,SUMO1,RNF8,KDM4B,UBE2V2,H2AX,H2BC17
R-HSA-451306	Ionotropic activity of Kainate Receptors	0.313926811510943	-1.15859540460232	12	5	0.00154846701765252	3229	10285	2897,1742,83988,1741,1739	GRIK1,DLG4,NCALD,DLG3,DLG1
R-HSA-5689877	Josephin domain DUBs	0.313926811510943	-1.15859540460232	12	5	0.00154846701765252	3229	10285	7311,5887,6233,7314,9929	UBA52,RAD23B,RPS27A,UBB,JOSD1
R-HSA-389359	CD28 dependent Vav1 pathway	0.313926811510943	-1.15859540460232	12	5	0.00154846701765252	3229	10285	998,942,5062,940,941	CDC42,CD86,PAK2,CD28,CD80
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.313926811510943	-1.15859540460232	12	5	0.00154846701765252	3229	10285	207,6697,2644,3320,5805	AKT1,SPR,GCHFR,HSP90AA1,PTS
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	0.313926811510943	-1.15859540460232	12	5	0.00154846701765252	3229	10285	1739,83988,1741,1742,2897	DLG1,NCALD,DLG3,DLG4,GRIK1
R-HSA-879518	Transport of organic anions	0.313926811510943	-1.15859540460232	12	5	0.00154846701765252	3229	10285	11309,28234,28232,213,6579	SLCO2B1,SLCO1B3,SLCO3A1,ALB,SLCO1A2
R-HSA-844456	The NLRP3 inflammasome	0.313926811510943	-1.15859540460232	12	5	0.00154846701765252	3229	10285	114548,3326,10628,29108,7295	NLRP3,HSP90AB1,TXNIP,PYCARD,TXN
R-HSA-5083633	Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	1605	DAG1
R-HSA-2408552	Methylation of MeSeH for excretion	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	11185	INMT
R-HSA-164516	Minus-strand DNA synthesis	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	5478	PPIA
R-HSA-5602410	TLR3 deficiency - HSE	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	7098	TLR3
R-HSA-5083629	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	1605	DAG1
R-HSA-5619110	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	213	ALB
R-HSA-164525	Plus-strand DNA synthesis	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	5478	PPIA
R-HSA-1839120	Signaling by FGFR1 amplification mutants	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	2260	FGFR1
R-HSA-3359474	Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	25974	MMACHC
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	2697	GJA1
R-HSA-5250982	Toxicity of tetanus toxin (TeNT)	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	6844	VAMP2
R-HSA-162589	Reverse Transcription of HIV RNA	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	5478	PPIA
R-HSA-171286	Synthesis and processing of ENV and VPU	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	5045	FURIN
R-HSA-5657655	MGMT-mediated DNA damage reversal	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	4255	MGMT
R-HSA-112122	ALKBH2 mediated reversal of alkylation damage	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	121642	ALKBH2
R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	3417	IDH1
R-HSA-5619058	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	213	ALB
R-HSA-5263617	Metabolism of ingested MeSeO2H into MeSeH	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	7296	TXNRD1
R-HSA-169131	Inhibition of PKR	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	5610	EIF2AK2
R-HSA-162585	Uncoating of the HIV Virion	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	5478	PPIA
R-HSA-1483196	PI and PC transport between ER and Golgi membranes	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	23760	PITPNB
R-HSA-1299287	Tandem pore domain halothane-inhibited K+ channel (THIK)	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	56659	KCNK13
R-HSA-5083628	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	1605	DAG1
R-HSA-389542	NADPH regeneration	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	3417	IDH1
R-HSA-5602415	UNC93B1 deficiency - HSE	0.31395235780024	-1.15851403133638	1	1	0.000309693403530505	3229	10285	7098	TLR3
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	1499,5516,5529,5518,5525,1452	CTNNB1,PPP2CB,PPP2R5E,PPP2R1A,PPP2R5A,CSNK1A1
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	5516,1499,1452,5518,5525,5529	PPP2CB,CTNNB1,CSNK1A1,PPP2R1A,PPP2R5A,PPP2R5E
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	5516,1499,5529,1452,5518,5525	PPP2CB,CTNNB1,PPP2R5E,CSNK1A1,PPP2R1A,PPP2R5A
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	5516,5529,1499,1452,5518,5525	PPP2CB,PPP2R5E,CTNNB1,CSNK1A1,PPP2R1A,PPP2R5A
R-HSA-5358508	Mismatch Repair	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	2956,5425,6119,5111,6118,57804	MSH6,POLD2,RPA3,PCNA,RPA2,POLD4
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	1499,5516,5518,5525,1452,5529	CTNNB1,PPP2CB,PPP2R1A,PPP2R5A,CSNK1A1,PPP2R5E
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	6233,7311,4233,867,7314,9146	RPS27A,UBA52,MET,CBL,UBB,HGS
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.32038423991121	-1.13823425378922	15	6	0.00185816042118303	3229	10285	1499,5516,1452,5525,5518,5529	CTNNB1,PPP2CB,CSNK1A1,PPP2R5A,PPP2R1A,PPP2R5E
R-HSA-1296071	Potassium Channels	0.320643169097619	-1.1374263969118	100	34	0.0105295757200372	3229	10285	56659,3756,3787,56479,2784,2793,10242,3759,2785,3779,2787,3751,2790,3738,3754,3766,3745,3752,54207,55970,3746,54331,131096,3767,3778,7881,2782,2550,170850,3737,89822,2788,3764,3760	KCNK13,KCNH1,KCNS1,KCNQ5,GNB3,GNGT2,KCNMB2,KCNJ2,GNG3,KCNMB1,GNG5,KCND2,GNG10,KCNA3,KCNF1,KCNJ10,KCNB1,KCND3,KCNK10,GNG12,KCNC1,GNG2,KCNH8,KCNJ11,KCNMA1,KCNAB1,GNB1,GABBR1,KCNG3,KCNA2,KCNK17,GNG7,KCNJ8,KCNJ3
R-HSA-4570464	SUMOylation of RNA binding proteins	0.322506628247317	-1.13163159025265	48	17	0.00526478786001858	3229	10285	79023,3190,3183,10762,51602,9972,23636,7329,6613,7703,407043,1911,6015,11097,129401,7341,57122	NUP37,HNRNPK,HNRNPC,NUP50,NOP58,NUP153,NUP62,UBE2I,SUMO2,PCGF2,MIR7-1,PHC1,RING1,NUP42,NUP35,SUMO1,NUP107
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	0.322506628247317	-1.13163159025265	48	17	0.00526478786001858	3229	10285	22861,7335,837,7295,29108,3326,10628,114548,3551,329,23118,5608,7189,10454,598,7128,7334	NLRP1,UBE2V1,CASP4,TXN,PYCARD,HSP90AB1,TXNIP,NLRP3,IKBKB,BIRC2,TAB2,MAP2K6,TRAF6,TAB1,BCL2L1,TNFAIP3,UBE2N
R-HSA-209776	Amine-derived hormones	0.324230883508033	-1.12629941355121	18	7	0.00216785382471353	3229	10285	1735,15,121278,438,1734,1733,1621	DIO3,AANAT,TPH2,ASMT,DIO2,DIO1,DBH
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.324230883508033	-1.12629941355121	18	7	0.00216785382471353	3229	10285	7529,51013,51010,207,54512,167227,11340	YWHAB,EXOSC1,EXOSC3,AKT1,EXOSC4,DCP2,EXOSC8
R-HSA-5654704	SHC-mediated cascade:FGFR3	0.324230883508033	-1.12629941355121	18	7	0.00216785382471353	3229	10285	2246,8822,3845,8074,3265,8823,6464	FGF1,FGF17,KRAS,FGF23,HRAS,FGF16,SHC1
R-HSA-418457	cGMP effects	0.324230883508033	-1.12629941355121	18	7	0.00216785382471353	3229	10285	3778,5153,5138,10242,5136,5152,3779	KCNMA1,PDE1B,PDE2A,KCNMB2,PDE1A,PDE9A,KCNMB1
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	0.324230883508033	-1.12629941355121	18	7	0.00216785382471353	3229	10285	1215,2028,407012,5972,4311,1509,10159	CMA1,ENPEP,MIR24-1,REN,MME,CTSD,ATP6AP2
R-HSA-73780	RNA Polymerase III Chain Elongation	0.324230883508033	-1.12629941355121	18	7	0.00216785382471353	3229	10285	51082,10621,171568,5441,5435,84265,55703	POLR1D,POLR3F,POLR3H,POLR2L,POLR2F,POLR3GL,POLR3B
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.324230883508033	-1.12629941355121	18	7	0.00216785382471353	3229	10285	5295,26127,8805,7750,5290,6776,6772	PIK3R1,FGFR1OP2,TRIM24,ZMYM2,PIK3CA,STAT5A,STAT1
R-HSA-373752	Netrin-1 signaling	0.324998076407628	-1.12393601541568	42	15	0.00464540105295757	3229	10285	59277,5781,6478,6477,5588,116986,4756,6714,5306,285704,8976,56963,998,7220,4690	NTN4,PTPN11,SIAH2,SIAH1,PRKCQ,AGAP2,NEO1,SRC,PITPNA,RGMB,WASL,RGMA,CDC42,TRPC1,NCK1
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.324998076407628	-1.12393601541568	42	15	0.00464540105295757	3229	10285	5465,4800,4801,4520,6309,9453,3157,6667,1387,6604,79071,2222,57678,4597,31	PPARA,NFYA,NFYB,MTF1,SC5D,GGPS1,HMGCS1,SP1,CREBBP,SMARCD3,ELOVL6,FDFT1,GPAM,MVD,ACACA
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	0.324998076407628	-1.12393601541568	42	15	0.00464540105295757	3229	10285	2788,2790,59345,2787,2791,2785,5906,2782,5567,51764,2793,2784,54331,55970,3745	GNG7,GNG10,GNB4,GNG5,GNG11,GNG3,RAP1A,GNB1,PRKACB,GNG13,GNGT2,GNB3,GNG2,GNG12,KCNB1
R-HSA-6782315	tRNA modification in the nucleus and cytosol	0.324998076407628	-1.12393601541568	42	15	0.00464540105295757	3229	10285	127253,51504,51605,24140,57570,54974,81605,23536,115708,54482,55644,79691,90353,60487,129450	TYW3,TRMT112,TRMT6,FTSJ1,TRMT5,THG1L,URM1,ADAT1,TRMT61A,TRMT13,OSGEP,QTRT2,CTU1,TRMT11,TYW5
R-HSA-5674135	MAP2K and MAPK activation	0.326069321756919	-1.12064527679471	39	14	0.00433570764942707	3229	10285	84292,1445,5894,5037,5906,5908,3265,28956,3845,5604,7529,7450,8649,6714	WDR83,CSK,RAF1,PEBP1,RAP1A,RAP1B,HRAS,LAMTOR2,KRAS,MAP2K1,YWHAB,VWF,LAMTOR3,SRC
R-HSA-6807004	Negative regulation of MET activity	0.326473927290051	-1.11940518861488	21	8	0.00247754722824404	3229	10285	5770,7311,6233,7314,9146,867,4233,9101	PTPN1,UBA52,RPS27A,UBB,HGS,CBL,MET,USP8
R-HSA-445144	Signal transduction by L1	0.326473927290051	-1.11940518861488	21	8	0.00247754722824404	3229	10285	1457,5604,2260,3897,1460,8829,7410,3685	CSNK2A1,MAP2K1,FGFR1,L1CAM,CSNK2B,NRP1,VAV2,ITGAV
R-HSA-418346	Platelet homeostasis	0.326773741914911	-1.11848726832203	91	31	0.00960049550944565	3229	10285	3779,2785,2983,51764,5136,5529,2790,2791,5516,2787,5525,5152,2784,2793,10242,5518,2782,6786,2788,59345,5138,5781,6717,54331,6546,80228,55970,2268,493,5153,3778	KCNMB1,GNG3,GUCY1B1,GNG13,PDE1A,PPP2R5E,GNG10,GNG11,PPP2CB,GNG5,PPP2R5A,PDE9A,GNB3,GNGT2,KCNMB2,PPP2R1A,GNB1,STIM1,GNG7,GNB4,PDE2A,PTPN11,SRI,GNG2,SLC8A1,ORAI2,GNG12,FGR,ATP2B4,PDE1B,KCNMA1
R-HSA-73777	RNA Polymerase I Chain Elongation	0.326773741914911	-1.11848726832203	91	31	0.00960049550944565	3229	10285	85236,8335,51082,4331,1022,2966,8345,84172,404672,5441,30834,8334,79101,255626,8331,5435,2071,100302240,3015,474382,8350,94239,3013,8970,8342,11335,902,2968,55766,8348,3014	H2BC12,H2AC4,POLR1D,MNAT1,CDK7,GTF2H2,H2BC9,POLR1B,GTF2H5,POLR2L,POLR1H,H2AC6,TAF1D,H2BC1,H2AC14,POLR2F,ERCC3,MIR1304,H2AZ1,H2AB1,H3C1,H2AZ2,H2AC7,H2BC11,H2BC14,CBX3,CCNH,GTF2H4,H2AJ,H2BC17,H2AX
R-HSA-432720	Lysosome Vesicle Biogenesis	0.326978250408919	-1.11786162280789	36	13	0.00402601424589656	3229	10285	8906,1785,8905,27243,8907,6844,8673,3312,6845,157807,375,134829,9146	AP1G2,DNM2,AP1S2,CHMP2A,AP1M1,VAMP2,VAMP8,HSPA8,VAMP7,CLVS1,ARF1,CLVS2,HGS
R-HSA-76046	RNA Polymerase III Transcription Initiation	0.326978250408919	-1.11786162280789	36	13	0.00402601424589656	3229	10285	51082,10621,6617,10302,6618,84265,55703,9329,171568,5441,9330,5435,6619	POLR1D,POLR3F,SNAPC1,SNAPC5,SNAPC2,POLR3GL,POLR3B,GTF3C4,POLR3H,POLR2L,GTF3C3,POLR2F,SNAPC3
R-HSA-1980145	Signaling by NOTCH2	0.327675497847746	-1.11573149614375	33	12	0.00371632084236606	3229	10285	1385,4853,1272,5664,2033,55851,23385,7311,3516,6233,51107,7314	CREB1,NOTCH2,CNTN1,PSEN2,EP300,PSENEN,NCSTN,UBA52,RBPJ,RPS27A,APH1A,UBB
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.328093299106763	-1.11445726254957	30	11	0.00340662743883555	3229	10285	1387,2033,4343,595,4853,26523,57690,7029,3516,3725,7157	CREBBP,EP300,MOV10,CCND1,NOTCH2,AGO1,TNRC6C,TFDP2,RBPJ,JUN,TP53
R-HSA-8863795	Downregulation of ERBB2 signaling	0.328093299106763	-1.11445726254957	30	11	0.00340662743883555	3229	10285	6233,7311,207,10000,3320,7314,10273,9101,10193,1839,208	RPS27A,UBA52,AKT1,AKT3,HSP90AA1,UBB,STUB1,USP8,RNF41,HBEGF,AKT2
R-HSA-917977	Transferrin endocytosis and recycling	0.328093299106763	-1.11445726254957	30	11	0.00340662743883555	3229	10285	534,528,8992,7018,57192,90423,9550,7037,51382,533,523	ATP6V1G2,ATP6V1C1,ATP6V0E1,TF,MCOLN1,ATP6V1E2,ATP6V1G1,TFRC,ATP6V1D,ATP6V0B,ATP6V1A
R-HSA-446728	Cell junction organization	0.328873713968698	-1.11208145002477	88	30	0.00929080210591514	3229	10285	9080,50855,23562,9074,9076,1500,55679,9073,977,1499,7016,3655,1364,9459,9069,5010,1012,10979,53842,3728,92359,1009,1495,100126326,3611,50848,1005,5819,1365,1006	CLDN9,PARD6A,CLDN14,CLDN6,CLDN1,CTNND1,LIMS2,CLDN8,CD151,CTNNB1,TESK1,ITGA6,CLDN4,ARHGEF6,CLDN12,CLDN11,CDH13,FERMT2,CLDN22,JUP,CRB3,CDH11,CTNNA1,MIR936,ILK,F11R,CDH7,NECTIN2,CLDN3,CDH8
R-HSA-535734	Fatty acid, triacylglycerol, and ketone body metabolism	0.334454937065296	-1.09525312578263	253	83	0.0257045524930319	3229	10285	55588,79966,5465,38,4706,3030,9967,4801,3293,51003,8841,6667,51495,23389,2182,9524,55750,1581,414149,55326,9412,9439,1387,6576,5538,2820,10449,2222,401494,84320,29079,84869,57678,693224,11010,55856,1024,51,55090,948,4594,4800,9442,4520,788,84246,64834,7923,2033,6604,10554,50486,400569,6785,3033,26063,83401,2712,31,5019,201562,5096,23179,25942,1543,8228,10005,3157,90390,5468,166785,1375,35,27349,1376,7296,79071,9200,641372,9440,6837,58526,79993	MED29,SCD5,PPARA,ACAT1,NDUFAB1,HADHA,THRAP3,NFYB,HSD17B3,MED31,HDAC3,SP1,HACD3,MED13L,ACSL4,TECR,AGK,CYP7A1,ACBD7,AGPAT5,MED21,MED23,CREBBP,SLC25A1,PPT1,GPD2,ACAA2,FDFT1,HACD4,ACBD6,MED4,CBR4,GPAM,MIR639,GLIPR1,ACOT13,CDK8,ACOX1,MED9,CD36,MMUT,NFYA,MED27,MTF1,SLC25A20,MED10,ELOVL1,HSD17B8,EP300,SMARCD3,AGPAT1,G0S2,MED11,ELOVL4,HADH,DECR2,ELOVL3,GK2,ACACA,OXCT1,HACD2,PCCB,RGL1,SIN3A,CYP1A1,PNPLA4,ACOT8,HMGCS1,MED30,PPARG,MMAA,CPT1B,ACADS,MCAT,CPT2,TXNRD1,ELOVL6,HACD1,ACOT6,MED17,MED22,MID1IP1,ELOVL7
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.338646133097265	-1.08279957196824	110	37	0.0114586559306287	3229	10285	5435,8331,29115,255626,79101,8334,5441,404672,30834,8345,84172,25942,2966,1022,4331,51082,8335,85236,3014,8348,55766,2968,902,8342,8970,10284,3013,8819,79685,94239,8467,8350,6839,474382,3015,100302240,2071	POLR2F,H2AC14,SAP30BP,H2BC1,TAF1D,H2AC6,POLR2L,GTF2H5,POLR1H,H2BC9,POLR1B,SIN3A,GTF2H2,CDK7,MNAT1,POLR1D,H2AC4,H2BC12,H2AX,H2BC17,H2AJ,GTF2H4,CCNH,H2BC14,H2BC11,SAP18,H2AC7,SAP30,SAP30L,H2AZ2,SMARCA5,H3C1,SUV39H1,H2AB1,H2AZ1,MIR1304,ERCC3
R-HSA-427413	NoRC negatively regulates rRNA expression	0.340979673202024	-1.07593241285356	107	36	0.0111489625270982	3229	10285	8342,8970,10284,2968,55766,902,3014,8348,100302240,2071,3015,8819,79685,94239,8350,8467,474382,3013,30834,5441,404672,84172,8345,2966,25942,29115,255626,79101,8334,5435,8331,85236,8335,4331,51082,1022	H2BC14,H2BC11,SAP18,GTF2H4,H2AJ,CCNH,H2AX,H2BC17,MIR1304,ERCC3,H2AZ1,SAP30,SAP30L,H2AZ2,H3C1,SMARCA5,H2AB1,H2AC7,POLR1H,POLR2L,GTF2H5,POLR1B,H2BC9,GTF2H2,SIN3A,SAP30BP,H2BC1,TAF1D,H2AC6,POLR2F,H2AC14,H2BC12,H2AC4,MNAT1,POLR1D,CDK7
R-HSA-5693607	Processing of DNA double-strand break ends	0.348235674959616	-1.05487580152687	98	33	0.0102198823165067	3229	10285	255626,7314,5932,5984,890,7311,5531,8345,6233,9656,5985,5810,6119,85236,5983,7329,4683,672,116028,3014,7336,8348,8970,6118,8342,7341,9025,29086,11073,5982,6613,7334,80010	H2BC1,UBB,RBBP8,RFC4,CCNA2,UBA52,PPP4C,H2BC9,RPS27A,MDC1,RFC5,RAD1,RPA3,H2BC12,RFC3,UBE2I,NBN,BRCA1,RMI2,H2AX,UBE2V2,H2BC17,H2BC11,RPA2,H2BC14,SUMO1,RNF8,BABAM1,TOPBP1,RFC2,SUMO2,UBE2N,RMI1
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.35410337983717	-1.03816637504349	55	19	0.00588417466707959	3229	10285	2222,79071,4597,31,57678,51128,10484,4800,51141,5465,5901,4520,4801,9453,6309,3157,6667,6604,1387	FDFT1,ELOVL6,MVD,ACACA,GPAM,SAR1B,SEC23A,NFYA,INSIG2,PPARA,RAN,MTF1,NFYB,GGPS1,SC5D,HMGCS1,SP1,SMARCD3,CREBBP
R-HSA-5693532	DNA Double-Strand Break Repair	0.360658900056817	-1.01982264251408	167	55	0.0170331371941778	3229	10285	3980,27343,23030,2237,7336,3014,7341,11073,29086,7520,79840,7334,64421,3838,56655,255626,5111,7157,5984,890,5932,6233,8345,5985,5810,6119,5983,55775,672,4683,7329,116028,8348,8970,8342,6118,5425,9025,8467,8314,57804,5982,6613,548593,80010,54107,10038,7314,9656,5531,7311,2140,5536,9031,85236	LIG3,POLL,KDM4B,FEN1,UBE2V2,H2AX,SUMO1,TOPBP1,BABAM1,XRCC5,NHEJ1,UBE2N,DCLRE1C,KPNA2,POLE4,H2BC1,PCNA,TP53,RFC4,CCNA2,RBBP8,RPS27A,H2BC9,RFC5,RAD1,RPA3,RFC3,TDP1,BRCA1,NBN,UBE2I,RMI2,H2BC17,H2BC11,H2BC14,RPA2,POLD2,RNF8,SMARCA5,BAP1,POLD4,RFC2,SUMO2,SLX1A,RMI1,POLE3,PARP2,UBB,MDC1,PPP4C,UBA52,EYA3,PPP5C,BAZ1B,H2BC12
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.361723288486602	-1.01687575590214	46	16	0.00495509445648808	3229	10285	60436,7323,4088,4087,3726,1874,7029,7314,1024,6233,7311,7321,1025,6667,4089,4609	TGIF2,UBE2D3,SMAD3,SMAD2,JUNB,E2F4,TFDP2,UBB,CDK8,RPS27A,UBA52,UBE2D1,CDK9,SP1,SMAD4,MYC
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.364330270104382	-1.00969448727379	43	15	0.00464540105295757	3229	10285	208,7088,607,1499,7314,7514,207,7311,6233,1487,6662,7534,6658,56998,6657	AKT2,TLE1,BCL9,CTNNB1,UBB,XPO1,AKT1,UBA52,RPS27A,CTBP1,SOX9,YWHAZ,SOX3,CTNNBIP1,SOX2
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.366965593851555	-1.00248718504563	40	14	0.00433570764942707	3229	10285	1026,4435,7422,1387,2033,4609,94115,7329,3815,7913,3329,7341,4605,79047	CDKN1A,CITED1,VEGFA,CREBBP,EP300,MYC,CGB8,UBE2I,KIT,DEK,HSPD1,SUMO1,MYBL2,KCTD15
R-HSA-5689896	Ovarian tumor domain proteases	0.36962330819304	-0.995270877910157	37	13	0.00402601424589656	3229	10285	5728,7157,7314,57506,7311,6233,79589,7189,64135,7321,7128,23586,56957	PTEN,TP53,UBB,MAVS,UBA52,RPS27A,RNF128,TRAF6,IFIH1,UBE2D1,TNFAIP3,RIGI,OTUD7B
R-HSA-3928663	EPHA-mediated growth cone collapse	0.372294219013682	-0.988070825987435	34	12	0.00371632084236606	3229	10285	103910,6714,9475,1969,6093,7422,1944,4637,1946,2043,3320,7525	MYL12B,SRC,ROCK2,EPHA2,ROCK1,VEGFA,EFNA3,MYL6,EFNA5,EPHA4,HSP90AA1,YES1
R-HSA-2408550	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	9060,7296	PAPSS2,TXNRD1
R-HSA-379401	Dopamine clearance from the synaptic cleft	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	1312,6531	COMT,SLC6A3
R-HSA-427975	Proton/oligopeptide cotransporters	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	6564,6565	SLC15A1,SLC15A2
R-HSA-390650	Histamine receptors	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	3274,11255	HRH2,HRH3
R-HSA-1296025	ATP sensitive Potassium channels	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	3767,3764	KCNJ11,KCNJ8
R-HSA-447115	Interleukin-12 signaling	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	3592,3593	IL12A,IL12B
R-HSA-417973	Adenosine P1 receptors	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	134,140	ADORA1,ADORA3
R-HSA-8847453	Synthesis of PIPs in the nucleus	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	79837,90809	PIP4K2C,PIP4P1
R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	3265,3845	HRAS,KRAS
R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	6616,9899	SNAP25,SV2B
R-HSA-399710	Activation of AMPA receptors	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	2890,2891	GRIA1,GRIA2
R-HSA-112126	ALKBH3 mediated reversal of alkylation damage	0.372976867762625	-0.986238877983624	4	2	0.00061938680706101	3229	10285	221120,51008	ALKBH3,ASCC1
R-HSA-352230	Amino acid transport across the plasma membrane	0.374964174306305	-0.980924792758689	31	11	0.00340662743883555	3229	10285	81539,23428,11136,6541,54407,6533,23657,6539,117247,124935,10991	SLC38A1,SLC7A8,SLC7A9,SLC7A1,SLC38A2,SLC6A6,SLC7A11,SLC6A12,SLC16A10,SLC43A2,SLC38A3
R-HSA-354192	Integrin alphaIIb beta3 signaling	0.377611243243159	-0.973890069616046	28	10	0.00309693403530505	3229	10285	6714,6464,5908,5906,10235,207,1445,5770,7450,6850	SRC,SHC1,RAP1B,RAP1A,RASGRP2,AKT1,CSK,PTPN1,VWF,SYK
R-HSA-70268	Pyruvate metabolism	0.377611243243159	-0.973890069616046	28	10	0.00309693403530505	3229	10285	3939,3945,51660,2739,5160,1737,57546,5162,92483,6566	LDHA,LDHB,MPC1,GLO1,PDHA1,DLAT,PDP2,PDHB,LDHAL6B,SLC16A1
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.380200889703956	-0.967055508835974	25	9	0.00278724063177454	3229	10285	1848,5518,4205,1845,1385,5516,4208,2002,466	DUSP6,PPP2R1A,MEF2A,DUSP3,CREB1,PPP2CB,MEF2C,ELK1,ATF1
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.380200889703956	-0.967055508835974	25	9	0.00278724063177454	3229	10285	207,10000,1027,4193,208,1026,572,1385,2931	AKT1,AKT3,CDKN1B,MDM2,AKT2,CDKN1A,BAD,CREB1,GSK3A
R-HSA-5654712	FRS-mediated FGFR4 signaling	0.382677306646063	-0.960563186333075	22	8	0.00247754722824404	3229	10285	8074,3845,5781,8823,3265,10817,8822,2246	FGF23,KRAS,PTPN11,FGF16,HRAS,FRS3,FGF17,FGF1
R-HSA-4641263	Regulation of FZD by ubiquitination	0.382677306646063	-0.960563186333075	22	8	0.00247754722824404	3229	10285	7311,6233,7314,4040,8323,8322,55366,9101	UBA52,RPS27A,UBB,LRP6,FZD6,FZD4,LGR4,USP8
R-HSA-164843	2-LTR circle formation	0.38475486716944	-0.955148856130193	7	3	0.000929080210591514	3229	10285	7520,8815,3159	XRCC5,BANF1,HMGA1
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	0.38475486716944	-0.955148856130193	7	3	0.000929080210591514	3229	10285	4968,5423,3980	OGG1,POLB,LIG3
R-HSA-182218	Nef Mediated CD8 Down-regulation	0.38475486716944	-0.955148856130193	7	3	0.000929080210591514	3229	10285	1175,160,1173	AP2S1,AP2A1,AP2M1
R-HSA-447043	Neurofascin interactions	0.38475486716944	-0.955148856130193	7	3	0.000929080210591514	3229	10285	6386,1272,8506	SDCBP,CNTN1,CNTNAP1
R-HSA-442720	CREB phosphorylation through the activation of Adenylate Cyclase	0.38475486716944	-0.955148856130193	7	3	0.000929080210591514	3229	10285	109,5567,1385	ADCY3,PRKACB,CREB1
R-HSA-5603029	IkBA variant leads to EDA-ID	0.38475486716944	-0.955148856130193	7	3	0.000929080210591514	3229	10285	3551,4790,4792	IKBKB,NFKB1,NFKBIA
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	0.384946897326868	-0.954649883228557	19	7	0.00216785382471353	3229	10285	51013,7534,207,51010,54512,167227,11340	EXOSC1,YWHAZ,AKT1,EXOSC3,EXOSC4,DCP2,EXOSC8
R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters	0.384946897326868	-0.954649883228557	19	7	0.00216785382471353	3229	10285	6539,6529,6531,6533,6534,6530,6538	SLC6A12,SLC6A1,SLC6A3,SLC6A6,SLC6A7,SLC6A2,SLC6A11
R-HSA-73864	RNA Polymerase I Transcription	0.387782388238481	-0.947310951752353	112	37	0.0114586559306287	3229	10285	3015,57504,2071,100302240,3013,474382,8350,5931,94239,5928,11335,8970,8342,8348,3014,902,55766,2968,51082,4331,9219,8335,85236,1022,2966,8345,84172,5441,404672,30834,53615,54700,8331,5435,79101,8334,255626	H2AZ1,MTA3,ERCC3,MIR1304,H2AC7,H2AB1,H3C1,RBBP7,H2AZ2,RBBP4,CBX3,H2BC11,H2BC14,H2BC17,H2AX,CCNH,H2AJ,GTF2H4,POLR1D,MNAT1,MTA2,H2AC4,H2BC12,CDK7,GTF2H2,H2BC9,POLR1B,POLR2L,GTF2H5,POLR1H,MBD3,RRN3,H2AC14,POLR2F,TAF1D,H2AC6,H2BC1
R-HSA-196108	Pregnenolone biosynthesis	0.387913526207018	-0.946972834798674	10	4	0.00123877361412202	3229	10285	83930,231,134429,6770	STARD3NL,AKR1B1,STARD4,STAR
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	0.387913526207018	-0.946972834798674	10	4	0.00123877361412202	3229	10285	4534,8898,9896,55697	MTM1,MTMR2,FIG4,VAC14
R-HSA-201688	WNT mediated activation of DVL	0.387913526207018	-0.946972834798674	10	4	0.00123877361412202	3229	10285	1460,1454,1457,1856	CSNK2B,CSNK1E,CSNK2A1,DVL2
R-HSA-190873	Gap junction degradation	0.387913526207018	-0.946972834798674	10	4	0.00123877361412202	3229	10285	4646,1173,1785,2697	MYO6,AP2M1,DNM2,GJA1
R-HSA-389887	Beta-oxidation of pristanoyl-CoA	0.387913526207018	-0.946972834798674	10	4	0.00123877361412202	3229	10285	1384,10005,23600,390916	CRAT,ACOT8,AMACR,NUDT19
R-HSA-112311	Neurotransmitter Clearance In The Synaptic Cleft	0.387913526207018	-0.946972834798674	10	4	0.00123877361412202	3229	10285	6532,1312,6531,43	SLC6A4,COMT,SLC6A3,ACHE
R-HSA-391160	Signal regulatory protein (SIRP) family interactions	0.388055020621681	-0.946608143686363	13	5	0.00154846701765252	3229	10285	8935,961,6714,7305,5781	SKAP2,CD47,SRC,TYROBP,PTPN11
R-HSA-2168880	Scavenging of heme from plasma	0.388055020621681	-0.946608143686363	13	5	0.00154846701765252	3229	10285	3512,3043,3240,213,3039	JCHAIN,HBB,HP,ALB,HBA1
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.388055020621681	-0.946608143686363	13	5	0.00154846701765252	3229	10285	7124,7128,7186,56957,9099	TNF,TNFAIP3,TRAF2,OTUD7B,USP2
R-HSA-977441	GABA A receptor activation	0.388055020621681	-0.946608143686363	13	5	0.00154846701765252	3229	10285	2554,2555,2561,2566,2562	GABRA1,GABRA2,GABRB2,GABRG2,GABRB3
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.388055020621681	-0.946608143686363	13	5	0.00154846701765252	3229	10285	890,1027,1026,57060,7157	CCNA2,CDKN1B,CDKN1A,PCBP4,TP53
R-HSA-5578775	Ion homeostasis	0.389191606639903	-0.943683494576255	56	19	0.00588417466707959	3229	10285	6546,5350,7220,80228,10768,1760,818,481,493,1193,3767,477,53826,2281,476,483,478,6786,6717	SLC8A1,PLN,TRPC1,ORAI2,AHCYL1,DMPK,CAMK2G,ATP1B1,ATP2B4,CLIC2,KCNJ11,ATP1A2,FXYD6,FKBP1B,ATP1A1,ATP1B3,ATP1A3,STIM1,SRI
R-HSA-6806667	Metabolism of fat-soluble vitamins	0.392772631821185	-0.934524379518864	53	18	0.00557448126354909	3229	10285	3949,26020,1594,29914,6383,7276,2239,9227,29967,338328,344,6385,51109,120227,1645,2817,5948,154807	LDLR,LRP10,CYP27B1,UBIAD1,SDC2,TTR,GPC4,LRAT,LRP12,GPIHBP1,APOC2,SDC4,RDH11,CYP2R1,AKR1C1,GPC1,RBP2,VKORC1L1
R-HSA-774815	Nucleosome assembly	0.404093939405599	-0.90610790476915	72	24	0.00743264168473212	3229	10285	8348,387103,3014,401541,55766,5928,11339,8342,8970,3013,5931,8467,94239,474382,8607,3015,8331,8334,255626,8345,79019,91687,8335,85236	H2BC17,CENPW,H2AX,CENPP,H2AJ,RBBP4,OIP5,H2BC14,H2BC11,H2AC7,RBBP7,SMARCA5,H2AZ2,H2AB1,RUVBL1,H2AZ1,H2AC14,H2AC6,H2BC1,H2BC9,CENPM,CENPL,H2AC4,H2BC12
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	0.404093939405599	-0.90610790476915	72	24	0.00743264168473212	3229	10285	8345,8331,8334,255626,91687,85236,8335,79019,5928,11339,8342,8970,8348,3014,387103,401541,55766,8607,3015,3013,94239,5931,8467,474382	H2BC9,H2AC14,H2AC6,H2BC1,CENPL,H2BC12,H2AC4,CENPM,RBBP4,OIP5,H2BC14,H2BC11,H2BC17,H2AX,CENPW,CENPP,H2AJ,RUVBL1,H2AZ1,H2AC7,H2AZ2,RBBP7,SMARCA5,H2AB1
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.404349212599441	-0.905476386766447	44	15	0.00464540105295757	3229	10285	129401,11097,1977,10898,100302196,57122,29894,53981,23636,9972,22916,100126351,79023,10762,10189	NUP35,NUP42,EIF4E,CPSF4,MIR1234,NUP107,CPSF1,CPSF2,NUP62,NUP153,NCBP2,MIR939,NUP37,NUP50,ALYREF
R-HSA-68875	Mitotic Prophase	0.406874574284068	-0.899250312326288	141	46	0.0142458965624032	3229	10285	10776,5516,3014,55766,11097,57122,79648,79023,3013,94239,54892,474382,5579,3015,891,8331,8334,255626,129401,8345,5862,4001,91754,9972,23636,26003,8335,8348,8815,7112,8342,8970,8350,10762,5861,81876,23592,5925,140609,5578,4000,10051,5518,7443,983,85236	ARPP19,PPP2CB,H2AX,H2AJ,NUP42,NUP107,MCPH1,NUP37,H2AC7,H2AZ2,NCAPG2,H2AB1,PRKCB,H2AZ1,CCNB1,H2AC14,H2AC6,H2BC1,NUP35,H2BC9,RAB2A,LMNB1,NEK9,NUP153,NUP62,GORASP2,H2AC4,H2BC17,BANF1,TMPO,H2BC14,H2BC11,H3C1,NUP50,RAB1A,RAB1B,LEMD3,RB1,NEK7,PRKCA,LMNA,SMC4,PPP2R1A,VRK1,CDK1,H2BC12
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.412931511615081	-0.88447353121314	38	13	0.00402601424589656	3229	10285	5983,80010,672,4683,11073,5985,5810,6119,5982,5984,6118,5932,116028	RFC3,RMI1,BRCA1,NBN,TOPBP1,RFC5,RAD1,RPA3,RFC2,RFC4,RPA2,RBBP8,RMI2
R-HSA-416482	G alpha (12/13) signalling events	0.415056795153042	-0.879339912324875	88	29	0.00898110870238464	3229	10285	148,2782,221472,59345,2788,9459,55970,5880,7074,54331,6093,9475,51764,84904,5290,2785,2791,388,2787,2790,7410,998,391,5296,2784,2793,5295,8503,6655	ADRA1A,GNB1,FGD2,GNB4,GNG7,ARHGEF6,GNG12,RAC2,TIAM1,GNG2,ROCK1,ROCK2,GNG13,ARHGEF39,PIK3CA,GNG3,GNG11,RHOB,GNG5,GNG10,VAV2,CDC42,RHOG,PIK3R2,GNB3,GNGT2,PIK3R1,PIK3R3,SOS2
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.416327978040711	-0.876281920600086	110	36	0.0111489625270982	3229	10285	5435,8331,54700,79101,8334,255626,2966,30834,5441,404672,84172,8345,53615,1022,51082,4331,9219,85236,8335,8348,3014,902,2968,55766,5928,8342,8970,3013,5931,94239,8350,474382,3015,57504,100302240,2071	POLR2F,H2AC14,RRN3,TAF1D,H2AC6,H2BC1,GTF2H2,POLR1H,POLR2L,GTF2H5,POLR1B,H2BC9,MBD3,CDK7,POLR1D,MNAT1,MTA2,H2BC12,H2AC4,H2BC17,H2AX,CCNH,GTF2H4,H2AJ,RBBP4,H2BC14,H2BC11,H2AC7,RBBP7,H2AZ2,H3C1,H2AB1,H2AZ1,MTA3,MIR1304,ERCC3
R-HSA-6802952	Signaling by BRAF and RAF fusions	0.420235825292329	-0.866939236489314	60	20	0.0061938680706101	3229	10285	5908,3265,3845,5604,4000,55109,1185,1445,5906,5894,5037,55750,10533,3717,8805,6714,7529,7450,57085,11044	RAP1B,HRAS,KRAS,MAP2K1,LMNA,AGGF1,CLCN6,CSK,RAP1A,RAF1,PEBP1,AGK,ATG7,JAK2,TRIM24,SRC,YWHAB,VWF,AGTRAP,TENT4A
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.422864313060188	-0.86070392430185	82	27	0.00836172189532363	3229	10285	11316,10749,55850,64837,51014,60561,10945,9554,23423,53407,26286,372,3797,54732,51226,8774,29127,6836,3796,8775,378,9371,11014,375,55738,81876,5861	COPE,KIF1C,USE1,KLC2,TMED7,RINT1,KDELR1,SEC22B,TMED3,STX18,ARFGAP3,ARCN1,KIF3C,TMED9,COPZ2,NAPG,RACGAP1,SURF4,KIF2A,NAPA,ARF4,KIF3B,KDELR2,ARF1,ARFGAP1,RAB1B,RAB1A
R-HSA-75109	Triglyceride Biosynthesis	0.422864313060188	-0.86070392430185	82	27	0.00836172189532363	3229	10285	693224,201562,83401,31,2712,9524,57678,79071,9200,401494,84320,2182,6785,79993,55750,55856,641372,3293,10005,55326,414149,79966,10554,6576,5538,51495,64834	MIR639,HACD2,ELOVL3,ACACA,GK2,TECR,GPAM,ELOVL6,HACD1,HACD4,ACBD6,ACSL4,ELOVL4,ELOVL7,AGK,ACOT13,ACOT6,HSD17B3,ACOT8,AGPAT5,ACBD7,SCD5,AGPAT1,SLC25A1,PPT1,HACD3,ELOVL1
R-HSA-3214858	RMTs methylate histone arginines	0.426956385398165	-0.851073412895027	79	26	0.00805202849179312	3229	10285	6598,8331,6605,8334,55170,6187,6604,8335,595,92815,8329,3014,55766,10419,79084,3015,51412,221613,1019,3717,3013,86,474382,5931,8350,94239	SMARCB1,H2AC14,SMARCE1,H2AC6,PRMT6,RPS2,SMARCD3,H2AC4,CCND1,H2AC25,H2AC13,H2AX,H2AJ,PRMT5,WDR77,H2AZ1,ACTL6B,H2AC1,CDK4,JAK2,H2AC7,ACTL6A,H2AB1,RBBP7,H3C1,H2AZ2
R-HSA-1793185	Chondroitin sulfate/dermatan sulfate metabolism	0.434156963247091	-0.834349143799332	51	17	0.00526478786001858	3229	10285	768213,55454,3073,2817,54480,83539,6385,6383,2239,166012,55790,50515,3074,79586,10090,11285,56548	MIR671,CSGALNACT2,HEXA,GPC1,CHPF2,CHST9,SDC4,SDC2,GPC4,CHST13,CSGALNACT1,CHST11,HEXB,CHPF,UST,B4GALT7,CHST7
R-HSA-5627123	RHO GTPases activate PAKs	0.439238106565516	-0.822713628967871	23	8	0.00247754722824404	3229	10285	5062,103910,4637,5500,4771,2017,4659,998	PAK2,MYL12B,MYL6,PPP1CB,NF2,CTTN,PPP1R12A,CDC42
R-HSA-8855121	VLDL interactions	0.439238106565516	-0.822713628967871	23	8	0.00247754722824404	3229	10285	29116,1175,7376,7436,255738,346,1173,160	MYLIP,AP2S1,NR1H2,VLDLR,PCSK9,APOC4,AP2M1,AP2A1
R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	0.439238106565516	-0.822713628967871	23	8	0.00247754722824404	3229	10285	51109,7276,3292,157506,145226,285440,8630,9227	RDH11,TTR,HSD17B1,RDH10,RDH12,CYP4V2,HSD17B6,LRAT
R-HSA-389948	PD-1 signaling	0.439238106565516	-0.822713628967871	23	8	0.00247754722824404	3229	10285	5781,920,5133,917,29126,919,1445,80380	PTPN11,CD4,PDCD1,CD3G,CD274,CD247,CSK,PDCD1LG2
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.439251783191136	-0.822682492296224	48	16	0.00495509445648808	3229	10285	7314,23493,3516,7311,10013,6233,1024,7088,2033,1387,55294,79885,4609,8841,6500,10014	UBB,HEY2,RBPJ,UBA52,HDAC6,RPS27A,CDK8,TLE1,EP300,CREBBP,FBXW7,HDAC11,MYC,HDAC3,SKP1,HDAC5
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	0.444623198841615	-0.810528099682386	45	15	0.00464540105295757	3229	10285	94241,581,8738,27166,604,355,5366,7157,5876,124446,3486,1387,332,665,9540	TP53INP1,BAX,CRADD,PRELID1,BCL6,FAS,PMAIP1,TP53,RABGGTB,TMEM219,IGFBP3,CREBBP,BIRC5,BNIP3L,TP53I3
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.444623198841615	-0.810528099682386	45	15	0.00464540105295757	3229	10285	10762,10189,79023,22916,100126351,23636,9972,53981,29894,10898,100302196,57122,129401,11097,1977	NUP50,ALYREF,NUP37,NCBP2,MIR939,NUP62,NUP153,CPSF2,CPSF1,CPSF4,MIR1234,NUP107,NUP35,NUP42,EIF4E
R-HSA-5654719	SHC-mediated cascade:FGFR4	0.445834880261274	-0.80780661914119	20	7	0.00216785382471353	3229	10285	8822,2246,3265,8823,6464,8074,3845	FGF17,FGF1,HRAS,FGF16,SHC1,FGF23,KRAS
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	0.445893946975511	-0.807674142288319	108	35	0.0108392691235677	3229	10285	3014,8348,55766,11335,5928,8970,8342,3013,474382,5931,94239,8350,8467,60,57504,3015,100302240,23451,7913,8331,5435,255626,8334,79101,84172,8345,30834,5441,53615,51082,2033,8335,85236,9219,9031	H2AX,H2BC17,H2AJ,CBX3,RBBP4,H2BC11,H2BC14,H2AC7,H2AB1,RBBP7,H2AZ2,H3C1,SMARCA5,ACTB,MTA3,H2AZ1,MIR1304,SF3B1,DEK,H2AC14,POLR2F,H2BC1,H2AC6,TAF1D,POLR1B,H2BC9,POLR1H,POLR2L,MBD3,POLR1D,EP300,H2AC4,H2BC12,MTA2,BAZ1B
R-HSA-196299	Beta-catenin phosphorylation cascade	0.453173134812845	-0.791481030462564	17	6	0.00185816042118303	3229	10285	5518,5525,1452,1499,5529,5516	PPP2R1A,PPP2R5A,CSNK1A1,CTNNB1,PPP2R5E,PPP2CB
R-HSA-2142845	Hyaluronan metabolism	0.453173134812845	-0.791481030462564	17	6	0.00185816042118303	3229	10285	11261,8692,3073,3074,3038,10057	CHP1,HYAL2,HEXA,HEXB,HAS3,ABCC5
R-HSA-70221	Glycogen breakdown (glycogenolysis)	0.453173134812845	-0.791481030462564	17	6	0.00185816042118303	3229	10285	5257,5236,5837,5834,5255,5260	PHKB,PGM1,PYGM,PYGB,PHKA1,PHKG1
R-HSA-432142	Platelet sensitization by LDL	0.453173134812845	-0.791481030462564	17	6	0.00185816042118303	3229	10285	2268,5781,5516,5525,5518,5529	FGR,PTPN11,PPP2CB,PPP2R5A,PPP2R1A,PPP2R5E
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.456362606539193	-0.784467595684704	39	13	0.00402601424589656	3229	10285	7056,2147,2158,5547,462,2155,5104,3053,7035,2159,2815,5627,7450	THBD,F2,F9,PRCP,SERPINC1,F7,SERPINA5,SERPIND1,TFPI,F10,GP9,PROS1,VWF
R-HSA-556833	Metabolism of lipids and lipoproteins	0.458971296705763	-0.778767605287052	813	257	0.0795912047073397	3229	10285	2876,6576,55697,9791,5901,1558,3073,9412,9536,29801,5007,693224,57107,2222,94101,23760,6667,9468,51003,79152,23683,213,171546,5465,4706,6770,79966,55750,80765,1584,1593,2167,1457,51170,1376,2877,29956,8228,29116,1460,5294,79993,9440,1384,126282,3631,1962,79071,9023,10554,50486,10478,64834,7923,3930,4800,4594,390916,79626,23179,11145,3290,201562,2712,25816,1387,1646,5045,414149,126410,5290,166929,11010,84869,84320,29881,8841,85465,1586,3988,8898,3417,51099,81579,4597,55349,6309,10005,8443,5296,6837,55224,8394,5728,79153,23600,7296,388121,4520,9415,948,10577,5500,5096,8706,83401,56623,3033,51552,4534,231,51228,649,9439,8503,50814,1645,9896,5476,55090,51,55856,51302,1173,1120,5867,3074,1175,6307,10449,23389,1800,9453,4801,10728,38,1585,3030,55588,84725,114971,4758,27306,1589,43,2182,3949,646486,9107,35,5730,27349,5468,90390,3157,3292,29923,5322,346,8560,5295,3636,10162,51763,117245,64180,63874,165679,641372,2173,94103,9200,6604,788,7357,128486,114882,5264,9442,64781,4952,161247,5567,1559,9489,9217,50640,400569,6785,2820,2531,5538,55326,344,80772,2879,23344,6901,6610,6579,1024,55711,79837,100137049,29079,57678,401494,51495,8904,28234,3293,9967,255738,3972,51141,253782,10484,338328,1581,259230,5501,23646,857,10423,9524,5868,51573,1375,1545,11283,166785,375,2171,1543,58526,160,51205,51128,56848,2033,84246,83930,7436,7376,90809,283927,134429,55331,25942,241,5019,22908,31,79644,26063,2581,56910	GPX1,SLC25A1,VAC14,PTDSS1,RAN,CYP2C8,HEXA,MED21,PTGES,ZDHHC8,OSBP,MIR639,PDSS2,FDFT1,ORMDL1,PITPNB,SP1,PCYT1B,MED31,FA2H,PRKD3,ALB,SPTSSA,PPARA,NDUFAB1,STAR,SCD5,AGK,STARD5,CYP11B1,CYP27A1,FABP4,CSNK2A1,HSD17B11,CPT2,GPX2,CERS2,PNPLA4,MYLIP,CSNK2B,PIK3CG,ELOVL7,MED17,CRAT,TNFAIP8L1,INPP4A,EHHADH,ELOVL6,CH25H,AGPAT1,G0S2,SLC25A17,ELOVL1,HSD17B8,LBR,NFYA,MMUT,NUDT19,TNFAIP8L2,RGL1,PLAAT3,HSD11B1,HACD2,GK2,TNFAIP8,CREBBP,AKR1C2,FURIN,ACBD7,CYP4F22,PIK3CA,SGMS2,GLIPR1,CBR4,ACBD6,NPC1L1,HDAC3,SELENOI,CYP17A1,LIPA,MTMR2,IDH1,ABHD5,PLA2G12A,MVD,CHDH,SC5D,ACOT8,GNPAT,PIK3R2,MED22,ETNK2,PIP5K1A,PTEN,GDPD3,AMACR,TXNRD1,TNFAIP8L3,MTF1,FADS2,CD36,NPC2,PPP1CB,PCCB,B3GALNT1,ELOVL3,INPP5E,HADH,RAB14,MTM1,AKR1B1,GLTP,BMP1,MED23,PIK3R3,NSDHL,AKR1C1,FIG4,CTSA,MED9,ACOX1,ACOT13,CYP39A1,AP2M1,CHKB,RAB4A,HEXB,AP2S1,MSMO1,ACAA2,MED13L,DPEP1,GGPS1,NFYB,PTGES3,ACAT1,CYP11B2,HADHA,MED29,PLEKHA8,PTPMT1,NEU1,HPGDS,CYP21A2,ACHE,ACSL4,LDLR,FABP12,MTMR6,ACADS,PTGDS,MCAT,PPARG,MED30,HMGCS1,HSD17B1,HILPDA,PLA2G5,APOC4,DEGS1,PIK3R1,INPPL1,LPCAT3,INPP5K,PLAAT5,DPEP3,ABHD4,SPTSSB,ACOT6,FABP7,ORMDL3,HACD1,SMARCD3,SLC25A20,UGCG,FITM2,OSBPL8,PHYH,MED27,CERK,OCRL,FITM1,PRKACB,CYP2C9,PGS1,VAPB,PNPLA8,MED11,ELOVL4,GPD2,KDSR,PPT1,AGPAT5,APOC2,CPTP,GPX4,ESYT1,TAFAZZIN,SMPD2,SLCO1A2,CDK8,FAR2,PIP4K2C,PLA2G4B,MED4,GPAM,HACD4,HACD3,CPNE1,SLCO1B3,HSD17B3,THRAP3,PCSK9,LHB,INSIG2,CERS6,SEC23A,GPIHBP1,CYP7A1,SGMS1,PPP1CC,PLD3,CAV1,CDIPT,TECR,RAB5A,GDE1,CPT1B,CYP1B1,CYP4F8,MMAA,ARF1,FABP5,CYP1A1,MID1IP1,AP2A1,ACP6,SAR1B,SPHK2,EP300,MED10,STARD3NL,VLDLR,NR1H2,PIP4P1,NUDT7,STARD4,ACER3,SIN3A,ALOX5AP,OXCT1,SACM1L,ACACA,SRD5A3,DECR2,GALC,STARD7
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.460256448748321	-0.775971447563912	58	19	0.00588417466707959	3229	10285	7314,23493,51107,7311,3516,10013,1024,6233,5664,6500,10014,55851,2033,1387,55294,23385,79885,4609,8841	UBB,HEY2,APH1A,UBA52,RBPJ,HDAC6,CDK8,RPS27A,PSEN2,SKP1,HDAC5,PSENEN,EP300,CREBBP,FBXW7,NCSTN,HDAC11,MYC,HDAC3
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.460256448748321	-0.775971447563912	58	19	0.00588417466707959	3229	10285	1024,6233,3516,10013,7311,23493,7314,51107,10014,5664,6500,79885,8841,4609,23385,2033,55851,1387,55294	CDK8,RPS27A,RBPJ,HDAC6,UBA52,HEY2,UBB,APH1A,HDAC5,PSEN2,SKP1,HDAC11,HDAC3,MYC,NCSTN,EP300,PSENEN,CREBBP,FBXW7
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.460256448748321	-0.775971447563912	58	19	0.00588417466707959	3229	10285	51107,23493,7314,1024,6233,10013,7311,3516,23385,55294,1387,2033,55851,8841,4609,79885,6500,5664,10014	APH1A,HEY2,UBB,CDK8,RPS27A,HDAC6,UBA52,RBPJ,NCSTN,FBXW7,CREBBP,EP300,PSENEN,HDAC3,MYC,HDAC11,SKP1,PSEN2,HDAC5
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.460256448748321	-0.775971447563912	58	19	0.00588417466707959	3229	10285	1387,2033,55851,55294,23385,79885,4609,8841,5664,6500,10014,7314,23493,51107,7311,3516,10013,1024,6233	CREBBP,EP300,PSENEN,FBXW7,NCSTN,HDAC11,MYC,HDAC3,PSEN2,SKP1,HDAC5,UBB,HEY2,APH1A,UBA52,RBPJ,HDAC6,CDK8,RPS27A
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.460256448748321	-0.775971447563912	58	19	0.00588417466707959	3229	10285	10014,5664,6500,79885,4609,8841,23385,1387,55851,2033,55294,6233,1024,10013,3516,7311,23493,7314,51107	HDAC5,PSEN2,SKP1,HDAC11,MYC,HDAC3,NCSTN,CREBBP,PSENEN,EP300,FBXW7,RPS27A,CDK8,HDAC6,RBPJ,UBA52,HEY2,UBB,APH1A
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	5525,5518,1452,5516,5529	PPP2R5A,PPP2R1A,CSNK1A1,PPP2CB,PPP2R5E
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	5516,5529,1452,5518,5525	PPP2CB,PPP2R5E,CSNK1A1,PPP2R1A,PPP2R5A
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	5425,6119,5111,6118,57804	POLD2,RPA3,PCNA,RPA2,POLD4
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	51302,1645,1593,1646,23600	CYP39A1,AKR1C1,CYP27A1,AKR1C2,AMACR
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	8898,4534,3631,9896,55697	MTMR2,MTM1,INPP4A,FIG4,VAC14
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	5529,5516,1452,5525,5518	PPP2R5E,PPP2CB,CSNK1A1,PPP2R5A,PPP2R1A
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	7157,5876,9540,604,332	TP53,RABGGTB,TP53I3,BCL6,BIRC5
R-HSA-5675482	Regulation of necroptotic cell death	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	7186,329,8743,355,356	TRAF2,BIRC2,TNFSF10,FAS,FASLG
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	5516,5529,5518,5525,1452	PPP2CB,PPP2R5E,PPP2R1A,PPP2R5A,CSNK1A1
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	5525,5518,1452,5516,5529	PPP2R5A,PPP2R1A,CSNK1A1,PPP2CB,PPP2R5E
R-HSA-177504	Retrograde neurotrophin signalling	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	1175,1173,1785,160,10126	AP2S1,AP2M1,DNM2,AP2A1,DNAL4
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	5525,5518,1452,5516,5529	PPP2R5A,PPP2R1A,CSNK1A1,PPP2CB,PPP2R5E
R-HSA-174403	Glutathione synthesis and recycling	0.461522516194871	-0.773224437074732	14	5	0.00154846701765252	3229	10285	55748,2729,79017,494143,2686	CNDP2,GCLC,GGCT,CHAC2,GGT7
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.462840605794689	-0.770372548110695	36	12	0.00371632084236606	3229	10285	10762,3836,79023,292,23636,9972,8815,3159,291,57122,129401,11097	NUP50,KPNA1,NUP37,SLC25A5,NUP62,NUP153,BANF1,HMGA1,SLC25A4,NUP107,NUP35,NUP42
R-HSA-1980148	Signaling by NOTCH3	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	55851,5664,51107,23385	PSENEN,PSEN2,APH1A,NCSTN
R-HSA-3296469	Defects in cobalamin (B12) metabolism	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	4594,166785,25974,27249	MMUT,MMAA,MMACHC,MMADHC
R-HSA-69416	Dimerization of procaspase-8	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	7186,355,356,8743	TRAF2,FAS,FASLG,TNFSF10
R-HSA-75072	mRNA Editing	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	9582,27350,200315,164668	APOBEC3B,APOBEC3C,APOBEC3A,APOBEC3H
R-HSA-1839122	Signaling by activated point mutants of FGFR1	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	2260,8074,8822,2246	FGFR1,FGF23,FGF17,FGF1
R-HSA-5218900	CASP8 activity is inhibited	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	7186,355,356,8743	TRAF2,FAS,FASLG,TNFSF10
R-HSA-1980150	Signaling by NOTCH4	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	55851,5664,51107,23385	PSENEN,PSEN2,APH1A,NCSTN
R-HSA-211999	CYP2E1 reactions	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	1565,1558,1572,1559	CYP2D6,CYP2C8,CYP2F1,CYP2C9
R-HSA-3371378	Regulation by c-FLIP	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	7186,356,355,8743	TRAF2,FASLG,FAS,TNFSF10
R-HSA-196780	Biotin transport and metabolism	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	5096,5091,8884,31	PCCB,PC,SLC5A6,ACACA
R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	1376,58526,788,1375	CPT2,MID1IP1,SLC25A20,CPT1B
R-HSA-1855183	Synthesis of IP2, IP, and Ins in the cytosol	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	3631,4952,3613,51477	INPP4A,OCRL,IMPA2,ISYNA1
R-HSA-193048	Androgen biosynthesis	0.47134677887501	-0.752161194991672	11	4	0.00123877361412202	3229	10285	3972,1586,3293,79644	LHB,CYP17A1,HSD17B3,SRD5A3
R-HSA-5669034	TNFs bind their physiological receptors	0.477413219936856	-0.739372873929901	30	10	0.00309693403530505	3229	10285	8764,7133,8741,356,60401,4049,3604,9966,8995,944	TNFRSF14,TNFRSF1B,TNFSF13,FASLG,EDA2R,LTA,TNFRSF9,TNFSF15,TNFSF18,TNFSF8
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.477777801781579	-0.73860950439619	68	22	0.00681325487767111	3229	10285	116028,5425,6118,5982,11073,57804,80010,56655,548593,54107,5111,6233,7311,5984,7314,5932,6119,5810,5985,672,4683,5983	RMI2,POLD2,RPA2,RFC2,TOPBP1,POLD4,RMI1,POLE4,SLX1A,POLE3,PCNA,RPS27A,UBA52,RFC4,UBB,RBBP8,RPA3,RAD1,RFC5,BRCA1,NBN,RFC3
R-HSA-5688849	Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	6441,653509,6440	SFTPD,SFTPA1,SFTPC
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	3693,948,3685	ITGB5,CD36,ITGAV
R-HSA-5688890	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	6440,6441,653509	SFTPC,SFTPD,SFTPA1
R-HSA-1483148	Synthesis of PG	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	114971,9489,23646	PTPMT1,PGS1,PLD3
R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	6675,64841,2673	UAP1,GNPNAT1,GFPT1
R-HSA-8937144	Aryl hydrocarbon receptor signalling	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	3326,9049,10728	HSP90AB1,AIP,PTGES3
R-HSA-444821	Relaxin receptors	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	6019,122042,117579	RLN2,RXFP2,RLN3
R-HSA-164944	Nef and signal transduction	0.483552220765558	-0.726595964201114	8	3	0.000929080210591514	3229	10285	919,5062,9844	CD247,PAK2,ELMO1
R-HSA-4615885	SUMOylation of DNA replication proteins	0.484736058692776	-0.724150745060928	46	15	0.00464540105295757	3229	10285	6613,23636,7329,9972,332,10762,7150,6612,79023,7155,57122,7341,129401,11097,5111	SUMO2,NUP62,UBE2I,NUP153,BIRC5,NUP50,TOP1,SUMO3,NUP37,TOP2B,NUP107,SUMO1,NUP35,NUP42,PCNA
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.485749411443151	-0.722062402370919	27	9	0.00278724063177454	3229	10285	84265,5435,55703,9329,171568,5441,51082,10621,9330	POLR3GL,POLR2F,POLR3B,GTF3C4,POLR3H,POLR2L,POLR1D,POLR3F,GTF3C3
R-HSA-400685	Sema4D in semaphorin signaling	0.485749411443151	-0.722062402370919	27	9	0.00278724063177454	3229	10285	4233,4637,388,9475,103910,998,391,5880,6093	MET,MYL6,RHOB,ROCK2,MYL12B,CDC42,RHOG,RAC2,ROCK1
R-HSA-70895	Branched-chain amino acid catabolism	0.495024171789936	-0.703148685706824	24	8	0.00247754722824404	3229	10285	1629,3028,10295,152926,38,549,36,6470	DBT,HSD17B10,BCKDK,PPM1K,ACAT1,AUH,ACADSB,SHMT1
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	0.495024171789936	-0.703148685706824	24	8	0.00247754722824404	3229	10285	3779,5152,2983,5136,5153,10242,5138,3778	KCNMB1,PDE9A,GUCY1B1,PDE1A,PDE1B,KCNMB2,PDE2A,KCNMA1
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	0.495024171789936	-0.703148685706824	24	8	0.00247754722824404	3229	10285	103910,9475,388,4637,6093,5880,391,998	MYL12B,ROCK2,RHOB,MYL6,ROCK1,RAC2,RHOG,CDC42
R-HSA-191273	Cholesterol biosynthesis	0.495024171789936	-0.703148685706824	24	8	0.00247754722824404	3229	10285	3930,3157,9453,6309,2222,6307,4597,50814	LBR,HMGCS1,GGPS1,SC5D,FDFT1,MSMO1,MVD,NSDHL
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.49940561265091	-0.694336662411252	40	13	0.00402601424589656	3229	10285	11073,5985,5810,6119,5982,5983,4683,80010,672,116028,5984,5932,6118	TOPBP1,RFC5,RAD1,RPA3,RFC2,RFC3,NBN,RMI1,BRCA1,RMI2,RFC4,RBBP8,RPA2
R-HSA-8866911	TFAP2 (AP-2) family regulates transcription of cell cycle factors	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	4609,1026	MYC,CDKN1A
R-HSA-8869496	TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	4605,3329	MYBL2,HSPD1
R-HSA-77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	35,3033	ACADS,HADH
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	3033,3030	HADH,HADHA
R-HSA-70370	Galactose catabolism	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	2582,5236	GALE,PGM1
R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	2280,7048	FKBP1A,TGFBR2
R-HSA-390651	Dopamine receptors	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	1812,1814	DRD1,DRD3
R-HSA-1606341	IRF3 mediated activation of type 1 IFN	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	3661,29110	IRF3,TBK1
R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	55294,6500	FBXW7,SKP1
R-HSA-3642278	Loss of Function of TGFBR2 in Cancer	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	2280,7048	FKBP1A,TGFBR2
R-HSA-112303	Electric Transmission Across Gap Junctions	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	84694,10052	GJA10,GJC1
R-HSA-964739	N-glycan trimming and elongation in the cis-Golgi	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	4245,10905	MGAT1,MAN1A2
R-HSA-69478	G2/M DNA replication checkpoint	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	891,983	CCNB1,CDK1
R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	6500,55294	SKP1,FBXW7
R-HSA-114516	Disinhibition of SNARE formation	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	5578,5579	PRKCA,PRKCB
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	3030,3033	HADHA,HADH
R-HSA-75157	FasL/ CD95L signaling	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	356,355	FASLG,FAS
R-HSA-3656535	TGFBR1 LBD Mutants in Cancer	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	2280,7048	FKBP1A,TGFBR2
R-HSA-427652	Sodium-coupled phosphate cotransporters	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	6574,6575	SLC20A1,SLC20A2
R-HSA-1614517	Sulfide oxidation to sulfate	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	7263,1468	TST,SLC25A10
R-HSA-426048	Arachidonate production from DAG	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	57406,26090	ABHD6,ABHD12
R-HSA-112307	Transmission across Electrical Synapses	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	10052,84694	GJC1,GJA10
R-HSA-2161517	Abacavir transmembrane transport	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	9429,5243	ABCG2,ABCB1
R-HSA-2142850	Hyaluronan biosynthesis and export	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	10057,3038	ABCC5,HAS3
R-HSA-389599	Alpha-oxidation of phytanate	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	10478,5264	SLC25A17,PHYH
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	0.500313526346069	-0.692520324383202	5	2	0.00061938680706101	3229	10285	3033,3030	HADH,HADHA
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	0.504358353627554	-0.684468244462806	72	23	0.00712294828120161	3229	10285	11258,55142,7532,3320,203068,22919,54820,8636,7283,1781,4751,7846,80321,8655,5518,983,1454,1069,10383,5048,619553,10121,95681	DCTN3,HAUS2,YWHAG,HSP90AA1,TUBB,MAPRE1,NDE1,SSNA1,TUBG1,DYNC1I2,NEK2,TUBA1A,CEP70,DYNLL1,PPP2R1A,CDK1,CSNK1E,CETN2,TUBB4B,PAFAH1B1,MIR484,ACTR1A,CEP41
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.504358353627554	-0.684468244462806	72	23	0.00712294828120161	3229	10285	3320,5518,22919,203068,8655,11258,7532,55142,1069,10383,7283,5048,1781,4751,10121,619553,80321,7846,95681,983,54820,1454,8636	HSP90AA1,PPP2R1A,MAPRE1,TUBB,DYNLL1,DCTN3,YWHAG,HAUS2,CETN2,TUBB4B,TUBG1,PAFAH1B1,DYNC1I2,NEK2,ACTR1A,MIR484,CEP70,TUBA1A,CEP41,CDK1,NDE1,CSNK1E,SSNA1
R-HSA-5423646	Aflatoxin activation and detoxification	0.505515356756834	-0.682176861642136	21	7	0.00216785382471353	3229	10285	4259,64180,1577,8574,2686,4258,1800	MGST3,DPEP3,CYP3A5,AKR7A2,GGT7,MGST2,DPEP1
R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.505515356756834	-0.682176861642136	21	7	0.00216785382471353	3229	10285	27249,25974,55788,440387,4594,166785,5644	MMADHC,MMACHC,LMBRD1,CTRB2,MMUT,MMAA,PRSS1
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.505515356756834	-0.682176861642136	21	7	0.00216785382471353	3229	10285	1387,665,581,94241,27166,7157,5366	CREBBP,BNIP3L,BAX,TP53INP1,PRELID1,TP53,PMAIP1
R-HSA-202733	Cell surface interactions at the vascular wall	0.510153298439331	-0.67304401325528	136	43	0.0133168163518117	3229	10285	5290,23428,11136,3512,3265,23657,120425,481,90952,3685,857,7056,961,6566,914,6464,7525,1048,4973,2207,6402,5627,9463,5295,3897,2817,4282,5296,483,5781,3655,3845,83692,2147,965,4072,5478,6383,50848,7102,284,6714,6385	PIK3CA,SLC7A8,SLC7A9,JCHAIN,HRAS,SLC7A11,JAML,ATP1B1,ESAM,ITGAV,CAV1,THBD,CD47,SLC16A1,CD2,SHC1,YES1,CEACAM5,OLR1,FCER1G,SELL,PROS1,PICK1,PIK3R1,L1CAM,GPC1,MIF,PIK3R2,ATP1B3,PTPN11,ITGA6,KRAS,CD99L2,F2,CD58,EPCAM,PPIA,SDC2,F11R,TSPAN7,ANGPT1,SRC,SDC4
R-HSA-504046	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.515490969511793	-0.662635493599431	149	47	0.0145555899659337	3229	10285	55766,2968,3014,5928,11335,474382,94239,3013,84265,2071,3015,10621,6617,57504,8334,255626,8331,9330,53615,8345,404672,55703,9219,6618,8335,902,8348,6619,8970,8342,9329,8350,5931,100302240,79101,54700,5435,2966,84172,5441,171568,30834,1022,10302,85236,51082,4331	H2AJ,GTF2H4,H2AX,RBBP4,CBX3,H2AB1,H2AZ2,H2AC7,POLR3GL,ERCC3,H2AZ1,POLR3F,SNAPC1,MTA3,H2AC6,H2BC1,H2AC14,GTF3C3,MBD3,H2BC9,GTF2H5,POLR3B,MTA2,SNAPC2,H2AC4,CCNH,H2BC17,SNAPC3,H2BC11,H2BC14,GTF3C4,H3C1,RBBP7,MIR1304,TAF1D,RRN3,POLR2F,GTF2H2,POLR1B,POLR2L,POLR3H,POLR1H,CDK7,SNAPC5,H2BC12,POLR1D,MNAT1
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.517644260475271	-0.658467028486711	18	6	0.00185816042118303	3229	10285	54512,167227,11340,51013,51010,7529	EXOSC4,DCP2,EXOSC8,EXOSC1,EXOSC3,YWHAB
R-HSA-196757	Metabolism of folate and pterines	0.517644260475271	-0.658467028486711	18	6	0.00185816042118303	3229	10285	81034,2350,441024,10840,6470,10588	SLC25A32,FOLR2,MTHFD2L,ALDH1L1,SHMT1,MTHFS
R-HSA-68877	Mitotic Prometaphase	0.523590925533818	-0.647044576009832	111	35	0.0108392691235677	3229	10285	6396,1457,5885,348235,79003,10051,5518,5501,983,79019,79980,5048,91687,619553,83540,3796,401541,5516,147841,57122,4085,7514,5529,22919,9184,991,54820,220134,1460,80776,79023,891,5525,10403,332	SEC13,CSNK2A1,RAD21,SKA2,MIS12,SMC4,PPP2R1A,PPP1CC,CDK1,CENPM,DSN1,PAFAH1B1,CENPL,MIR484,NUF2,KIF2A,CENPP,PPP2CB,SPC24,NUP107,MAD2L1,XPO1,PPP2R5E,MAPRE1,BUB3,CDC20,NDE1,SKA1,CSNK2B,B9D2,NUP37,CCNB1,PPP2R5A,NDC80,BIRC5
R-HSA-112043	PLC beta mediated events	0.524298243307092	-0.645694589958392	47	15	0.00464540105295757	3229	10285	5153,10768,1385,2781,406974,2771,109,2775,23236,2773,5330,5136,5578,108,5567	PDE1B,AHCYL1,CREB1,GNAZ,MIR197,GNAI2,ADCY3,GNAO1,PLCB1,GNAI3,PLCB2,PDE1A,PRKCA,ADCY2,PRKACB
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.524298243307092	-0.645694589958392	47	15	0.00464540105295757	3229	10285	5045,595,5870,4853,26523,2033,1387,6484,2683,4343,3725,7157,57690,7029,3516	FURIN,CCND1,RAB6A,NOTCH2,AGO1,EP300,CREBBP,ST3GAL4,B4GALT1,MOV10,JUN,TP53,TNRC6C,TFDP2,RBPJ
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.528663944982481	-0.637402313673345	124	39	0.0120780427376897	3229	10285	11006,10666,910,11024,10870,958,947,11027,131450,5819,10859,4345,8778,4277,2213,959,51348,3383,912,8174,4068,919,259197,909,3824,3385,567,7305,3384,2209,9976,975,120425,374383,6402,340205,911,11026,917	LILRB4,CD226,CD1B,LILRA1,HCST,CD40,CD34,LILRA2,CD200R1,NECTIN2,LILRB1,CD200,SIGLEC5,MICB,FCGR2B,CD40LG,KLRF1,ICAM1,CD1D,MADCAM1,SH2D1A,CD247,NCR3,CD1A,KLRD1,ICAM3,B2M,TYROBP,ICAM2,FCGR1A,CLEC2B,CD81,JAML,NCR3LG1,SELL,TREML1,CD1C,LILRA3,CD3G
R-HSA-6804754	Regulation of TP53 Expression	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	7157	TP53
R-HSA-165160	PDE3B signalling	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	208	AKT2
R-HSA-168316	Assembly of Viral Components at the Budding Site	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	811	CALR
R-HSA-351143	Agmatine biosynthesis	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	113451	AZIN2
R-HSA-451307	Activation of Na-permeable Kainate Receptors	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	2897	GRIK1
R-HSA-203754	NOSIP mediated eNOS trafficking	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	51070	NOSIP
R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	89822	KCNK17
R-HSA-888568	GABA synthesis	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	2572	GAD2
R-HSA-168268	Virus Assembly and Release	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	811	CALR
R-HSA-3828062	Glycogen storage disease type 0 (muscle GYS1)	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	2997	GYS1
R-HSA-480985	Synthesis of dolichyl-phosphate-glucose	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	29880	ALG5
R-HSA-141424	Amplification of signal from the kinetochores	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	4085	MAD2L1
R-HSA-166020	Transfer of LPS from LBP carrier to CD14	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	929	CD14
R-HSA-1483101	Synthesis of PS	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	9791	PTDSS1
R-HSA-156582	Acetylation	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	10	NAT2
R-HSA-3814836	Glycogen storage disease type XV (GYG1)	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	2997	GYS1
R-HSA-5688354	Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	6440	SFTPC
R-HSA-141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	4085	MAD2L1
R-HSA-192905	vRNP Assembly	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	3320	HSP90AA1
R-HSA-5683177	Defective ABCC8 can cause hypoglycemias and hyperglycemias	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	3767	KCNJ11
R-HSA-211736	Stimulation of the cell death response by PAK-2p34	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	5062	PAK2
R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	7048	TGFBR2
R-HSA-141334	PAOs oxidise polyamines to amines	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	196743	PAOX
R-HSA-111452	Activation and oligomerization of BAK protein	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	578	BAK1
R-HSA-211728	Regulation of PAK-2p34 activity by PS-GAP/RHG10	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	5062	PAK2
R-HSA-168315	Inhibition of Host mRNA Processing and RNA Silencing	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	10898	CPSF4
R-HSA-114294	Activation, translocation and oligomerization of BAX	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	581	BAX
R-HSA-75896	Plasmalogen biosynthesis	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	8443	GNPAT
R-HSA-5687868	Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)	0.52935957644542	-0.636087349404427	2	1	0.000309693403530505	3229	10285	6441	SFTPD
R-HSA-997269	Inhibition of adenylate cyclase pathway	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	2773,2771,108,109,406974	GNAI3,GNAI2,ADCY2,ADCY3,MIR197
R-HSA-156581	Methylation	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	9446,1312,4144,27430,51504	GSTO1,COMT,MAT2A,MAT2B,TRMT112
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	51,83401,10005,64834,9415	ACOX1,ELOVL3,ACOT8,ELOVL1,FADS2
R-HSA-5682910	LGI-ADAM interactions	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	1742,9211,10368,6804,203190	DLG4,LGI1,CACNG3,STX1A,LGI3
R-HSA-211935	Fatty acids	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	11283,126410,66002,1565,1572	CYP4F8,CYP4F22,CYP4F12,CYP2D6,CYP2F1
R-HSA-391903	Eicosanoid ligand-binding receptors	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	2840,5731,5732,5737,5734	GPR17,PTGER1,PTGER2,PTGFR,PTGER4
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	11197,6422,22943,50964,4040	WIF1,SFRP1,DKK1,SOST,LRP6
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	10005,83401,51,9415,64834	ACOT8,ELOVL3,ACOX1,FADS2,ELOVL1
R-HSA-170670	Adenylate cyclase inhibitory pathway	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	2771,108,109,406974,2773	GNAI2,ADCY2,ADCY3,MIR197,GNAI3
R-HSA-69298	Association of licensing factors with the pre-replicative complex	0.532091654349893	-0.630939521866857	15	5	0.00154846701765252	3229	10285	7314,5001,7311,6233,51053	UBB,ORC5,UBA52,RPS27A,GMNN
R-HSA-975634	Retinoid metabolism and transport	0.532637204238801	-0.629914754044985	44	14	0.00433570764942707	3229	10285	3949,26020,9227,29967,7276,2239,6383,5948,344,338328,6385,1645,2817,51109	LDLR,LRP10,LRAT,LRP12,TTR,GPC4,SDC2,RBP2,APOC2,GPIHBP1,SDC4,AKR1C1,GPC1,RDH11
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.536972754278616	-0.621807922671763	28	9	0.00278724063177454	3229	10285	9330,5441,171568,9329,51082,10621,55703,84265,5435	GTF3C3,POLR2L,POLR3H,GTF3C4,POLR1D,POLR3F,POLR3B,POLR3GL,POLR2F
R-HSA-211976	Endogenous sterols	0.536972754278616	-0.621807922671763	28	9	0.00278724063177454	3229	10285	285440,1581,1545,51302,1584,1593,1589,1586,1585	CYP4V2,CYP7A1,CYP1B1,CYP39A1,CYP11B1,CYP27A1,CYP21A2,CYP17A1,CYP11B2
R-HSA-1266695	Interleukin-7 signaling	0.536972754278616	-0.621807922671763	28	9	0.00278724063177454	3229	10285	6776,3716,8503,5295,8350,3561,5296,3574,5896	STAT5A,JAK1,PIK3R3,PIK3R1,H3C1,IL2RG,PIK3R2,IL7,RAG1
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.541593340445573	-0.613239853535051	41	13	0.00402601424589656	3229	10285	51082,10621,6617,10302,6618,84265,55703,5441,171568,9329,9330,5435,6619	POLR1D,POLR3F,SNAPC1,SNAPC5,SNAPC2,POLR3GL,POLR3B,POLR2L,POLR3H,GTF3C4,GTF3C3,POLR2F,SNAPC3
R-HSA-74158	RNA Polymerase III Transcription	0.541593340445573	-0.613239853535051	41	13	0.00402601424589656	3229	10285	171568,5441,9329,9330,5435,6619,51082,10621,6617,10302,6618,84265,55703	POLR3H,POLR2L,GTF3C4,GTF3C3,POLR2F,SNAPC3,POLR1D,POLR3F,SNAPC1,SNAPC5,SNAPC2,POLR3GL,POLR3B
R-HSA-5617833	Cilium Assembly	0.544961473665127	-0.607040177340288	192	60	0.0185816042118303	3229	10285	5518,55763,149371,56623,79598,55770,11336,5048,1069,8766,983,1454,6102,54585,84100,3797,55081,83657,10576,123016,11258,10640,7283,1781,132320,80321,4751,54820,27077,129880,8655,22948,10383,6950,95681,619553,10121,2847,84747,3320,203068,57728,10694,22919,10013,8195,79969,51098,51668,64792,55142,7532,378,9371,7846,23322,5147,26160,8636,80776	PPP2R1A,EXOC1,EXOC8,INPP5E,CEP97,EXOC2,EXOC3,PAFAH1B1,CETN2,RAB11A,CDK1,CSNK1E,RP2,LZTFL1,ARL6,KIF3C,IFT57,DYNLRB2,CCT2,TTC8,DCTN3,EXOC5,TUBG1,DYNC1I2,SCLT1,CEP70,NEK2,NDE1,B9D1,BBS5,DYNLL1,CCT5,TUBB4B,TCP1,CEP41,MIR484,ACTR1A,MCHR1,UNC119B,HSP90AA1,TUBB,WDR19,CCT8,MAPRE1,HDAC6,MKKS,ATAT1,IFT52,IFT25,IFT22,HAUS2,YWHAG,ARF4,KIF3B,TUBA1A,RPGRIP1L,PDE6D,IFT172,SSNA1,B9D2
R-HSA-1538133	G0 and Early G1	0.549058657491803	-0.599549998932681	25	8	0.00247754722824404	3229	10285	5928,7029,4605,890,1874,5111,983,1859	RBBP4,TFDP2,MYBL2,CCNA2,E2F4,PCNA,CDK1,DYRK1A
R-HSA-211981	Xenobiotics	0.549058657491803	-0.599549998932681	25	8	0.00247754722824404	3229	10285	1565,1572,1559,1562,64816,1577,1558,1543	CYP2D6,CYP2F1,CYP2C9,CYP2C18,CYP3A43,CYP3A5,CYP2C8,CYP1A1
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	0.549058657491803	-0.599549998932681	25	8	0.00247754722824404	3229	10285	6396,567,51128,10484,2923,811,3309,6892	SEC13,B2M,SAR1B,SEC23A,PDIA3,CALR,HSPA5,TAPBP
R-HSA-425410	Metal ion SLC transporters	0.549058657491803	-0.599549998932681	25	8	0.00247754722824404	3229	10285	29985,4891,57181,148867,254428,64924,7922,1317	SLC39A3,SLC11A2,SLC39A10,SLC30A7,SLC41A1,SLC30A5,SLC39A7,SLC31A1
R-HSA-390666	Serotonin receptors	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	3350,3355,3361,3356	HTR1A,HTR1F,HTR5A,HTR2A
R-HSA-3656237	Defective EXT2 causes exostoses 2	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	2239,2817,6383,6385	GPC4,GPC1,SDC2,SDC4
R-HSA-190373	FGFR1c ligand binding and activation	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	8822,2246,8074,2260	FGF17,FGF1,FGF23,FGFR1
R-HSA-210990	PECAM1 interactions	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	3685,5781,7525,6714	ITGAV,PTPN11,YES1,SRC
R-HSA-71064	Lysine catabolism	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	89874,85007,1743,1428	SLC25A21,PHYKPL,DLST,CRYM
R-HSA-2160916	Hyaluronan uptake and degradation	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	3073,3074,11261,8692	HEXA,HEXB,CHP1,HYAL2
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	124446,355,7157,3486	TMEM219,FAS,TP53,IGFBP3
R-HSA-3656253	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	6385,6383,2239,2817	SDC4,SDC2,GPC4,GPC1
R-HSA-1433617	Regulation of signaling by NODAL	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	130399,9350,55997,91	ACVR1C,CER1,CFC1,ACVR1B
R-HSA-2033514	FGFR3 mutant receptor activation	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	8823,2246,8822,8074	FGF16,FGF1,FGF17,FGF23
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	2056,7422,2033,1387	EPO,VEGFA,EP300,CREBBP
R-HSA-1839130	Signaling by activated point mutants of FGFR3	0.550056762573798	-0.597733801401224	12	4	0.00123877361412202	3229	10285	8823,8074,2246,8822	FGF16,FGF23,FGF1,FGF17
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.551271091884235	-0.595528591031535	38	12	0.00371632084236606	3229	10285	1445,207,5906,10235,6850,5770,2147,5908,2815,7450,6714,6464	CSK,AKT1,RAP1A,RASGRP2,SYK,PTPN1,F2,RAP1B,GP9,VWF,SRC,SHC1
R-HSA-383280	Nuclear Receptor transcription pathway	0.554132138787519	-0.590352103008668	51	16	0.00495509445648808	3229	10285	6096,5465,5241,7376,5468,6258,190,2100,7101,29982,7421,9970,4929,8856,2063,367	RORB,PPARA,PGR,NR1H2,PPARG,RXRG,NR0B1,ESR2,NR2E1,NRBF2,VDR,NR1I3,NR4A2,NR1I2,NR2F6,AR
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.556852033707388	-0.58545572298594	93	29	0.00898110870238464	3229	10285	9031,8335,85236,2033,51082,79101,8334,255626,5435,8331,7913,23451,5441,30834,8345,84172,94239,8350,8467,474382,3013,100302240,3015,60,55766,8348,3014,8342,8970	BAZ1B,H2AC4,H2BC12,EP300,POLR1D,TAF1D,H2AC6,H2BC1,POLR2F,H2AC14,DEK,SF3B1,POLR2L,POLR1H,H2BC9,POLR1B,H2AZ2,H3C1,SMARCA5,H2AB1,H2AC7,MIR1304,H2AZ1,ACTB,H2AJ,H2BC17,H2AX,H2BC14,H2BC11
R-HSA-5625740	RHO GTPases activate PKNs	0.556852033707388	-0.58545572298594	93	29	0.00898110870238464	3229	10285	23028,7529,3015,3013,94239,8350,474382,8342,8970,4637,3014,388,7532,8348,2810,55766,354,8335,7534,85236,103910,4659,8345,5500,7533,367,8331,255626,8334	KDM1A,YWHAB,H2AZ1,H2AC7,H2AZ2,H3C1,H2AB1,H2BC14,H2BC11,MYL6,H2AX,RHOB,YWHAG,H2BC17,SFN,H2AJ,KLK3,H2AC4,YWHAZ,H2BC12,MYL12B,PPP1R12A,H2BC9,PPP1CB,YWHAH,AR,H2AC14,H2BC1,H2AC6
R-HSA-5578749	Transcriptional regulation by small RNAs	0.560098388873273	-0.579642816268839	106	33	0.0102198823165067	3229	10285	255626,5436,8334,8331,5435,10526,8345,5433,129401,5441,26523,5431,85236,8335,23636,9972,55766,5432,3014,8348,8970,8342,57122,11097,5438,474382,94239,10762,8350,5901,3013,79023,3015	H2BC1,POLR2G,H2AC6,H2AC14,POLR2F,IPO8,H2BC9,POLR2D,NUP35,POLR2L,AGO1,POLR2B,H2BC12,H2AC4,NUP62,NUP153,H2AJ,POLR2C,H2AX,H2BC17,H2BC11,H2BC14,NUP107,NUP42,POLR2I,H2AB1,H2AZ2,NUP50,H3C1,RAN,H2AC7,NUP37,H2AZ1
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.561803116982984	-0.576603816119867	35	11	0.00340662743883555	3229	10285	140609,57122,91754,11097,129401,10762,983,79023,891,9972,23636	NEK7,NUP107,NEK9,NUP42,NUP35,NUP50,CDK1,NUP37,CCNB1,NUP153,NUP62
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.561803116982984	-0.576603816119867	35	11	0.00340662743883555	3229	10285	6714,7450,7529,5604,3845,3265,5908,5894,5037,5906,1445	SRC,VWF,YWHAB,MAP2K1,KRAS,HRAS,RAP1B,RAF1,PEBP1,RAP1A,CSK
R-HSA-5620916	VxPx cargo-targeting to cilium	0.562839780135481	-0.574760273696297	22	7	0.00216785382471353	3229	10285	55763,8766,10640,11336,378,55770,149371	EXOC1,RAB11A,EXOC5,EXOC3,ARF4,EXOC2,EXOC8
R-HSA-198753	ERK/MAPK targets	0.562839780135481	-0.574760273696297	22	7	0.00216785382471353	3229	10285	4208,5516,2002,4205,1848,5518,1845	MEF2C,PPP2CB,ELK1,MEF2A,DUSP6,PPP2R1A,DUSP3
R-HSA-140875	Common Pathway of Fibrin Clot Formation	0.562839780135481	-0.574760273696297	22	7	0.00216785382471353	3229	10285	7056,5104,2147,3053,2159,462,5627	THBD,SERPINA5,F2,SERPIND1,F10,SERPINC1,PROS1
R-HSA-112040	G-protein mediated events	0.562955725161317	-0.57455429485609	48	15	0.00464540105295757	3229	10285	2773,5330,108,5567,5578,5136,2775,23236,2771,109,10768,5153,2781,406974,1385	GNAI3,PLCB2,ADCY2,PRKACB,PRKCA,PDE1A,GNAO1,PLCB1,GNAI2,ADCY3,AHCYL1,PDE1B,GNAZ,MIR197,CREB1
R-HSA-428157	Sphingolipid metabolism	0.563024236038131	-0.574432603743887	90	28	0.00867141529885413	3229	10285	56848,94103,3074,5007,166929,23344,6610,80772,165679,8560,3073,5476,29956,51228,2531,9217,2581,4758,8706,55331,259230,171546,23683,79152,64781,253782,94101,7357	SPHK2,ORMDL3,HEXB,OSBP,SGMS2,ESYT1,SMPD2,CPTP,SPTSSB,DEGS1,HEXA,CTSA,CERS2,GLTP,KDSR,VAPB,GALC,NEU1,B3GALNT1,ACER3,SGMS1,SPTSSA,PRKD3,FA2H,CERK,CERS6,ORMDL1,UGCG
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.565854495348802	-0.569418309183961	103	32	0.00991018891297615	3229	10285	79019,79980,983,619553,83540,5048,91687,348235,6396,5885,5501,79003,5518,220134,80776,79023,991,54820,10403,332,891,5525,5516,147841,3796,401541,5529,22919,9184,4085,57122,7514	CENPM,DSN1,CDK1,MIR484,NUF2,PAFAH1B1,CENPL,SKA2,SEC13,RAD21,PPP1CC,MIS12,PPP2R1A,SKA1,B9D2,NUP37,CDC20,NDE1,NDC80,BIRC5,CCNB1,PPP2R5A,PPP2CB,SPC24,KIF2A,CENPP,PPP2R5E,MAPRE1,BUB3,MAD2L1,NUP107,XPO1
R-HSA-6802957	Oncogenic MAPK signaling	0.567075652752842	-0.567262557783036	74	23	0.00712294828120161	3229	10285	55109,4000,10533,55750,5894,5245,5908,4296,3845,5604,8805,6714,1185,8315,1445,5037,5906,3265,7529,11044,7450,57085,3717	AGGF1,LMNA,ATG7,AGK,RAF1,PHB1,RAP1B,MAP3K11,KRAS,MAP2K1,TRIM24,SRC,CLCN6,BRAP,CSK,PEBP1,RAP1A,HRAS,YWHAB,TENT4A,VWF,AGTRAP,JAK2
R-HSA-196854	Metabolism of vitamins and cofactors	0.569902330289028	-0.56229028320582	174	54	0.0167234437906473	3229	10285	1528,441024,2350,113278,9962,6515,60496,6513,154807,9446,1645,344,54,3949,10560,9227,29914,1594,5948,120227,952,5644,338328,440387,26020,7276,2239,1727,166785,81034,6470,119391,25974,8884,51109,2817,55163,83594,5096,31,10243,29967,10588,6383,316,79178,27249,55788,4594,54981,5091,10840,80704,6385	CYB5A,MTHFD2L,FOLR2,SLC52A3,SLC23A2,SLC2A3,AASDHPPT,SLC2A1,VKORC1L1,GSTO1,AKR1C1,APOC2,ACP5,LDLR,SLC19A2,LRAT,UBIAD1,CYP27B1,RBP2,CYP2R1,CD38,PRSS1,GPIHBP1,CTRB2,LRP10,TTR,GPC4,CYB5R3,MMAA,SLC25A32,SHMT1,GSTO2,MMACHC,SLC5A6,RDH11,GPC1,PNPO,NUDT12,PCCB,ACACA,GPHN,LRP12,MTHFS,SDC2,AOX1,THTPA,MMADHC,LMBRD1,MMUT,NMRK1,PC,ALDH1L1,SLC19A3,SDC4
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.572385464739363	-0.557942625159363	45	14	0.00433570764942707	3229	10285	51399,3673,3685,5578,59277,780,3655,1605,8573,3913,7276,6383,6385,3693	TRAPPC4,ITGA2,ITGAV,PRKCA,NTN4,DDR1,ITGA6,DAG1,CASK,LAMB2,TTR,SDC2,SDC4,ITGB5
R-HSA-6794361	Interactions of neurexins and neuroligins at synapses	0.573007339641039	-0.556856753202769	58	18	0.00557448126354909	3229	10285	1742,347731,22839,64130,22871,9454,26037,127833,26045,57555,8573,6804,55327,6812,1741,9456,347730,2911	DLG4,LRRTM3,DLGAP4,LIN7B,NLGN1,HOMER3,SIPA1L1,SYT2,LRRTM2,NLGN2,CASK,STX1A,LIN7C,STXBP1,DLG3,HOMER1,LRRTM1,GRM1
R-HSA-168638	NOD1/2 Signaling Pathway	0.573361154140856	-0.556239474355748	32	10	0.00309693403530505	3229	10285	7189,5608,7335,837,23118,329,3551,7334,7128,10454	TRAF6,MAP2K6,UBE2V1,CASP4,TAB2,BIRC2,IKBKB,UBE2N,TNFAIP3,TAB1
R-HSA-447041	CHL1 interactions	0.573931402790675	-0.55524539713746	9	3	0.000929080210591514	3229	10285	8829,3312,3673	NRP1,HSPA8,ITGA2
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.573931402790675	-0.55524539713746	9	3	0.000929080210591514	3229	10285	5366,598,572	PMAIP1,BCL2L1,BAD
R-HSA-71336	Pentose phosphate pathway (hexose monophosphate shunt)	0.573931402790675	-0.55524539713746	9	3	0.000929080210591514	3229	10285	22934,6120,2539	RPIA,RPE,G6PD
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	0.573931402790675	-0.55524539713746	9	3	0.000929080210591514	3229	10285	23479,2395,81894	ISCU,FXN,SLC25A28
R-HSA-5340588	RNF mutants show enhanced WNT signaling and proliferation	0.573931402790675	-0.55524539713746	9	3	0.000929080210591514	3229	10285	4040,8323,8322	LRP6,FZD6,FZD4
R-HSA-1296052	Ca2+ activated K+ channels	0.573931402790675	-0.55524539713746	9	3	0.000929080210591514	3229	10285	10242,3779,3778	KCNMB2,KCNMB1,KCNMA1
R-HSA-196025	Formation of annular gap junctions	0.573931402790675	-0.55524539713746	9	3	0.000929080210591514	3229	10285	2697,1785,1173	GJA1,DNM2,AP2M1
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.576498795827487	-0.550782028039321	126	39	0.0120780427376897	3229	10285	8331,5316,5435,8334,5436,5080,3221,255626,2146,8345,5433,5441,8841,79447,2033,5431,85236,3211,8335,8348,8726,57472,3014,5432,55766,3725,5928,5438,8970,8342,3013,474382,5931,8350,94239,1959,3015,7703,1387	H2AC14,PKNOX1,POLR2F,H2AC6,POLR2G,PAX6,HOXC4,H2BC1,EZH2,H2BC9,POLR2D,POLR2L,HDAC3,PAGR1,EP300,POLR2B,H2BC12,HOXB1,H2AC4,H2BC17,EED,CNOT6,H2AX,POLR2C,H2AJ,JUN,RBBP4,POLR2I,H2BC11,H2BC14,H2AC7,H2AB1,RBBP7,H3C1,H2AZ2,EGR2,H2AZ1,PCGF2,CREBBP
R-HSA-5619507	Activation of HOX genes during differentiation	0.576498795827487	-0.550782028039321	126	39	0.0120780427376897	3229	10285	5432,55766,3725,8348,8726,57472,3014,8970,8342,5928,5438,474382,8350,5931,94239,1959,3013,7703,1387,3015,8334,5436,3221,5080,255626,8331,5316,5435,2146,8345,5433,5441,79447,5431,2033,8335,85236,3211,8841	POLR2C,H2AJ,JUN,H2BC17,EED,CNOT6,H2AX,H2BC11,H2BC14,RBBP4,POLR2I,H2AB1,H3C1,RBBP7,H2AZ2,EGR2,H2AC7,PCGF2,CREBBP,H2AZ1,H2AC6,POLR2G,HOXC4,PAX6,H2BC1,H2AC14,PKNOX1,POLR2F,EZH2,H2BC9,POLR2D,POLR2L,PAGR1,POLR2B,EP300,H2AC4,H2BC12,HOXB1,HDAC3
R-HSA-3928664	Ephrin signaling	0.578889197297193	-0.54664418881202	19	6	0.00185816042118303	3229	10285	2051,1947,5062,6714,10627,6386	EPHB6,EFNB1,PAK2,SRC,MYL12A,SDCBP
R-HSA-5223345	Miscellaneous transport and binding events	0.578889197297193	-0.54664418881202	19	6	0.00185816042118303	3229	10285	81614,56172,7991,119,118,563	NIPA2,ANKH,TUSC3,ADD2,ADD1,AZGP1
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	0.578889197297193	-0.54664418881202	19	6	0.00185816042118303	3229	10285	10454,5602,23118,7334,7335,7189	TAB1,MAPK10,TAB2,UBE2N,UBE2V1,TRAF6
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	0.578889197297193	-0.54664418881202	19	6	0.00185816042118303	3229	10285	56623,22908,4952,375,9896,55697	INPP5E,SACM1L,OCRL,ARF1,FIG4,VAC14
R-HSA-2990846	SUMOylation	0.579854579564629	-0.544977931766983	110	34	0.0105295757200372	3229	10285	129401,205564,9656,6015,7155,5111,7157,56160,5885,7329,23636,9972,672,1069,5371,6612,4286,8554,7150,11097,57122,7341,25950,4193,332,51602,1911,407043,6613,7703,3183,79023,3190,10762	NUP35,SENP5,MDC1,RING1,TOP2B,PCNA,TP53,NSMCE3,RAD21,UBE2I,NUP62,NUP153,BRCA1,CETN2,PML,SUMO3,MITF,PIAS1,TOP1,NUP42,NUP107,SUMO1,RWDD3,MDM2,BIRC5,NOP58,PHC1,MIR7-1,SUMO2,PCGF2,HNRNPC,NUP37,HNRNPK,NUP50
R-HSA-373755	Semaphorin interactions	0.581925987449713	-0.541412008667795	68	21	0.0065035614741406	3229	10285	1400,388,4637,4233,7305,1020,1072,9037,8829,3320,3326,8482,5062,9475,103910,998,10154,8851,5880,391,6093	CRMP1,RHOB,MYL6,MET,TYROBP,CDK5,CFL1,SEMA5A,NRP1,HSP90AA1,HSP90AB1,SEMA7A,PAK2,ROCK2,MYL12B,CDC42,PLXNC1,CDK5R1,RAC2,RHOG,ROCK1
R-HSA-375170	CDO in myogenesis	0.586172532867094	-0.534141108051694	29	9	0.00278724063177454	3229	10285	100271849,998,4205,5608,1495,4208,4756,1499,1496	MEF2B,CDC42,MEF2A,MAP2K6,CTNNA1,MEF2C,NEO1,CTNNB1,CTNNA2
R-HSA-525793	Myogenesis	0.586172532867094	-0.534141108051694	29	9	0.00278724063177454	3229	10285	5608,1495,4208,4756,1496,1499,100271849,998,4205	MAP2K6,CTNNA1,MEF2C,NEO1,CTNNA2,CTNNB1,MEF2B,CDC42,MEF2A
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	0.591738619067686	-0.524690263442725	104	32	0.00991018891297615	3229	10285	3183,79023,3190,10762,332,51602,4193,407043,7703,6613,1911,11097,57122,7341,4286,6612,7150,8554,9972,672,7329,23636,1069,5371,7157,5111,5885,56160,9656,6015,129401,7155	HNRNPC,NUP37,HNRNPK,NUP50,BIRC5,NOP58,MDM2,MIR7-1,PCGF2,SUMO2,PHC1,NUP42,NUP107,SUMO1,MITF,SUMO3,TOP1,PIAS1,NUP153,BRCA1,UBE2I,NUP62,CETN2,PML,TP53,PCNA,RAD21,NSMCE3,MDC1,RING1,NUP35,TOP2B
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.593452640918841	-0.521797864377736	39	12	0.00371632084236606	3229	10285	8428,4000,51765,6709,4001,1499,5588,118,2620,6093,329,6304	STK24,LMNA,STK26,SPTAN1,LMNB1,CTNNB1,PRKCQ,ADD1,GAS2,ROCK1,BIRC2,SATB1
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	0.593452640918841	-0.521797864377736	39	12	0.00371632084236606	3229	10285	2911,259286,50833,50837,259292,2918,54429,259285,2550,50838,80834,2912	GRM1,TAS2R40,TAS2R16,TAS2R7,TAS2R46,GRM8,TAS2R5,TAS2R39,GABBR1,TAS2R13,TAS1R2,GRM2
R-HSA-8854518	AURKA Activation by TPX2	0.597412028046782	-0.515148239410879	75	23	0.00712294828120161	3229	10285	3320,203068,22919,55142,7532,11258,1781,7283,7846,80321,4751,54820,8636,5518,8655,5048,1069,10383,95681,619553,10121,983,1454	HSP90AA1,TUBB,MAPRE1,HAUS2,YWHAG,DCTN3,DYNC1I2,TUBG1,TUBA1A,CEP70,NEK2,NDE1,SSNA1,PPP2R1A,DYNLL1,PAFAH1B1,CETN2,TUBB4B,CEP41,MIR484,ACTR1A,CDK1,CSNK1E
R-HSA-373760	L1CAM interactions	0.597938248757426	-0.514267793310938	101	31	0.00960049550944565	3229	10285	3673,3685,3312,1739,6327,214,1457,5604,6324,55800,6711,1741,6714,6386,6900,160,1173,6709,8829,1742,4478,1175,1785,2260,11313,8506,7410,8986,3897,1272,1460	ITGA2,ITGAV,HSPA8,DLG1,SCN2B,ALCAM,CSNK2A1,MAP2K1,SCN1B,SCN3B,SPTBN1,DLG3,SRC,SDCBP,CNTN2,AP2A1,AP2M1,SPTAN1,NRP1,DLG4,MSN,AP2S1,DNM2,FGFR1,LYPLA2,CNTNAP1,VAV2,RPS6KA4,L1CAM,CNTN1,CSNK2B
R-HSA-5218859	Regulated Necrosis	0.598113184046284	-0.513975271960589	16	5	0.00154846701765252	3229	10285	329,8743,355,356,7186	BIRC2,TNFSF10,FAS,FASLG,TRAF2
R-HSA-399954	Sema3A PAK dependent Axon repulsion	0.598113184046284	-0.513975271960589	16	5	0.00154846701765252	3229	10285	3326,1072,5062,8829,3320	HSP90AB1,CFL1,PAK2,NRP1,HSP90AA1
R-HSA-1433559	Regulation of KIT signaling	0.598113184046284	-0.513975271960589	16	5	0.00154846701765252	3229	10285	6714,7525,867,3815,5578	SRC,YES1,CBL,KIT,PRKCA
R-HSA-5213460	RIPK1-mediated regulated necrosis	0.598113184046284	-0.513975271960589	16	5	0.00154846701765252	3229	10285	356,355,8743,329,7186	FASLG,FAS,TNFSF10,BIRC2,TRAF2
R-HSA-446353	Cell-extracellular matrix interactions	0.598113184046284	-0.513975271960589	16	5	0.00154846701765252	3229	10285	55679,9459,10979,7016,3611	LIMS2,ARHGEF6,FERMT2,TESK1,ILK
R-HSA-975298	Ligand-gated ion channel transport	0.600546196033815	-0.509915711139048	26	8	0.00247754722824404	3229	10285	2742,2555,2562,2566,2554,2741,2561,2743	GLRA2,GABRA2,GABRB3,GABRG2,GABRA1,GLRA1,GABRB2,GLRB
R-HSA-3560782	Diseases associated with glycosaminoglycan metabolism	0.600546196033815	-0.509915711139048	26	8	0.00247754722824404	3229	10285	2817,6385,5549,2239,6383,4060,4969,2331	GPC1,SDC4,PRELP,GPC4,SDC2,LUM,OGN,FMOD
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	0.600546196033815	-0.509915711139048	26	8	0.00247754722824404	3229	10285	10383,7846,6950,10694,10576,22948,10376,10574	TUBB4B,TUBA1A,TCP1,CCT8,CCT2,CCT5,TUBA1B,CCT7
R-HSA-6794362	Protein-protein interactions at synapses	0.605129873804448	-0.502312176543686	72	22	0.00681325487767111	3229	10285	9456,1741,6812,347730,2911,55327,2890,6804,10211,127833,26045,79414,57555,8573,64130,22839,347731,1742,26037,1739,9454,22871	HOMER1,DLG3,STXBP1,LRRTM1,GRM1,LIN7C,GRIA1,STX1A,FLOT1,SYT2,LRRTM2,LRFN3,NLGN2,CASK,LIN7B,DLGAP4,LRRTM3,DLG4,SIPA1L1,DLG1,HOMER3,NLGN1
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	0.605346621914673	-0.501954056227748	36	11	0.00340662743883555	3229	10285	10097,10810,10109,26999,8976,10787,60,10094,998,4690,51517	ACTR2,WASF3,ARPC2,CYFIP2,WASL,NCKAP1,ACTB,ARPC3,CDC42,NCK1,NCKIPSD
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	11108,8841	PRDM4,HDAC3
R-HSA-388479	Vasopressin-like receptors	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	553,5021	AVPR1B,OXTR
R-HSA-5626978	TNFR1-mediated ceramide production	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	6610,7124	SMPD2,TNF
R-HSA-5674499	Negative feedback regulation of MAPK pathway	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	5604,5894	MAP2K1,RAF1
R-HSA-6793080	rRNA modification in the mitochondrion	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	29960,51106	MRM2,TFB1M
R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	10457,1839	GPNMB,HBEGF
R-HSA-1482798	Acyl chain remodeling of CL	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	3030,6901	HADHA,TAFAZZIN
R-HSA-3000484	Scavenging by Class F Receptors	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	811,3320	CALR,HSP90AA1
R-HSA-6806942	MET Receptor Activation	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	4233,10653	MET,SPINT2
R-HSA-166662	Lectin pathway of complement activation	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	4153,2220	MBL2,FCN2
R-HSA-5693548	Sensing of DNA Double Strand Breaks	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	4683,3838	NBN,KPNA2
R-HSA-177135	Conjugation of benzoate with glycine	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	10249,389396	GLYAT,GLYATL3
R-HSA-193144	Estrogen biosynthesis	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	51170,3292	HSD17B11,HSD17B1
R-HSA-5624138	Trafficking of myristoylated proteins to the cilium	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	6102,84747	RP2,UNC119B
R-HSA-68616	Assembly of the ORC complex at the origin of replication	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	5001,23594	ORC5,ORC6
R-HSA-111957	Cam-PDE 1 activation	0.609518955929007	-0.495085229758529	6	2	0.00061938680706101	3229	10285	5136,5153	PDE1A,PDE1B
R-HSA-73980	RNA Polymerase III Transcription Termination	0.616915512321189	-0.483023197481799	23	7	0.00216785382471353	3229	10285	171568,5441,51082,10621,84265,5435,55703	POLR3H,POLR2L,POLR1D,POLR3F,POLR3GL,POLR2F,POLR3B
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.618377679757238	-0.480655875896474	33	10	0.00309693403530505	3229	10285	79023,8815,3159,3836,10762,9972,129401,23636,11097,57122	NUP37,BANF1,HMGA1,KPNA1,NUP50,NUP153,NUP35,NUP62,NUP42,NUP107
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.621814330048623	-0.475113735549346	43	13	0.00402601424589656	3229	10285	5983,672,80010,4683,11073,5985,5810,6119,5982,5984,6118,5932,116028	RFC3,BRCA1,RMI1,NBN,TOPBP1,RFC5,RAD1,RPA3,RFC2,RFC4,RPA2,RBBP8,RMI2
R-HSA-194068	Bile acid and bile salt metabolism	0.621814330048623	-0.475113735549346	43	13	0.00402601424589656	3229	10285	23600,9023,1581,6579,80765,5007,1593,51302,213,10005,1646,1645,28234	AMACR,CH25H,CYP7A1,SLCO1A2,STARD5,OSBP,CYP27A1,CYP39A1,ALB,ACOT8,AKR1C2,AKR1C1,SLCO1B3
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	0.621814330048623	-0.475113735549346	43	13	0.00402601424589656	3229	10285	1281,948,3043,2512,213,7184,2495,3512,811,3320,3240,1278,3039	COL3A1,CD36,HBB,FTL,ALB,HSP90B1,FTH1,JCHAIN,CALR,HSP90AA1,HP,COL1A2,HBA1
R-HSA-75892	Platelet Adhesion to exposed collagen	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	3673,2207,7450,2815	ITGA2,FCER1G,VWF,GP9
R-HSA-5210891	Uptake and function of anthrax toxins	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	5608,5604,5045,5606	MAP2K6,MAP2K1,FURIN,MAP2K3
R-HSA-2408517	SeMet incorporation into proteins	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	5917,3735,4141,9521	RARS1,KARS1,MARS1,EEF1E1
R-HSA-190375	FGFR2c ligand binding and activation	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	2246,8822,8074,8823	FGF1,FGF17,FGF23,FGF16
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	8822,2246,8074,8823	FGF17,FGF1,FGF23,FGF16
R-HSA-190372	FGFR3c ligand binding and activation	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	8074,8822,2246,8823	FGF23,FGF17,FGF1,FGF16
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	64135,57506,3551,23586	IFIH1,MAVS,IKBKB,RIGI
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	2033,1385,3516,4853	EP300,CREB1,RBPJ,NOTCH2
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	29110,7520,3661,3428	TBK1,XRCC5,IRF3,IFI16
R-HSA-202670	ERKs are inactivated	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	5516,1848,5518,1845	PPP2CB,DUSP6,PPP2R1A,DUSP3
R-HSA-432047	Passive transport by Aquaporins	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	360,361,282679,359	AQP3,AQP4,AQP11,AQP2
R-HSA-190239	FGFR3 ligand binding and activation	0.622057536774989	-0.474722687667403	13	4	0.00123877361412202	3229	10285	8074,8822,2246,8823	FGF23,FGF17,FGF1,FGF16
R-HSA-5693538	Homology Directed Repair	0.628150148212396	-0.464976051581096	138	42	0.0130071229482812	3229	10285	255626,5111,54107,5932,7314,890,10038,5984,8345,7311,5531,9656,6233,5985,5810,6119,85236,5983,7329,672,4683,116028,3980,7336,3014,8348,2237,8342,6118,8970,7341,9025,5425,57804,29086,11073,5982,548593,7334,6613,56655,80010	H2BC1,PCNA,POLE3,RBBP8,UBB,CCNA2,PARP2,RFC4,H2BC9,UBA52,PPP4C,MDC1,RPS27A,RFC5,RAD1,RPA3,H2BC12,RFC3,UBE2I,BRCA1,NBN,RMI2,LIG3,UBE2V2,H2AX,H2BC17,FEN1,H2BC14,RPA2,H2BC11,SUMO1,RNF8,POLD2,POLD4,BABAM1,TOPBP1,RFC2,SLX1A,UBE2N,SUMO2,POLE4,RMI1
R-HSA-157118	Signaling by NOTCH	0.628950182002424	-0.463703227322269	112	34	0.0105295757200372	3229	10285	4609,55851,1387,6484,1272,4853,10014,1385,5045,1024,10013,23493,51107,7088,3725,79885,8841,4343,23385,2683,2033,55294,26523,595,5870,5664,6500,6233,3516,7311,7314,7029,57690,7157	MYC,PSENEN,CREBBP,ST3GAL4,CNTN1,NOTCH2,HDAC5,CREB1,FURIN,CDK8,HDAC6,HEY2,APH1A,TLE1,JUN,HDAC11,HDAC3,MOV10,NCSTN,B4GALT1,EP300,FBXW7,AGO1,CCND1,RAB6A,PSEN2,SKP1,RPS27A,RBPJ,UBA52,UBB,TFDP2,TNRC6C,TP53
R-HSA-157858	Gap junction trafficking and regulation	0.63278366698816	-0.457626673563185	30	9	0.00278724063177454	3229	10285	4646,1173,2697,84694,10052,6714,2706,1785,2705	MYO6,AP2M1,GJA1,GJA10,GJC1,SRC,GJB2,DNM2,GJB1
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.63375851017891	-0.45608729587671	40	12	0.00371632084236606	3229	10285	5610,10762,3836,79023,23636,3838,9972,9636,10898,57122,11097,129401	EIF2AK2,NUP50,KPNA1,NUP37,NUP62,KPNA2,NUP153,ISG15,CPSF4,NUP107,NUP42,NUP35
R-HSA-382551	Transmembrane transport of small molecules	0.634027181900902	-0.455663451803232	677	209	0.0647259213378755	3229	10285	7314,861,392399,6048,2788,10213,6546,9550,55970,51000,5720,6534,26503,108,5694,5683,51458,122706,5685,9356,5704,57282,6005,5689,10762,6529,10396,2030,2554,6564,27032,29988,23,23169,9429,9972,5698,213,493,6558,124935,1244,118,8504,6538,1080,5718,117247,2512,2784,2793,481,79023,5894,8992,140679,1468,51310,3163,359,79901,2495,161003,5716,51764,8894,2787,7220,2566,28232,10057,6505,5710,361,7991,5243,5682,1965,10559,282679,6566,23636,2040,7355,6530,115286,11097,7018,5690,5707,9376,6574,284111,389812,2791,5700,6515,56172,360,6513,7922,1193,5567,81539,6533,6541,6507,51009,54331,90423,5350,5713,6539,8766,2741,2542,5699,148867,5705,23457,81614,109,5693,5684,10956,5695,5709,2281,6506,129401,84912,59345,6717,85414,6565,57127,254428,9861,5721,2555,2785,57122,477,57181,9498,2742,11059,533,11309,28962,10613,1179,119,1317,2743,2782,7311,483,57578,41,57192,6531,3767,2561,29985,5691,528,5686,2790,7037,27248,10991,8884,11160,3933,6233,476,286256,5702,116085,1831,6059,7979,51382,28234,5692,523,2562,40,563,5687,23428,534,6579,11136,53826,1185,478,54407,64924,55343,23657,4891,6575,818,79139,63982,6041,92579	UBB,RUNX1,LCN9,RNF5,GNG7,PSMD14,SLC8A1,ATP6V1G1,GNG12,SLC35B3,PSME1,SLC6A7,SLC17A5,ADCY2,PSMB6,PSMA2,RHCG,PSMB11,PSMA4,SLC22A6,PSMC4,SLC4A10,RHAG,PSMB1,NUP50,SLC6A1,ATP8A1,SLC29A1,GABRA1,SLC15A1,ATP2C1,SLC2A8,ABCF1,SLC35D1,ABCG2,NUP153,PSMB9,ALB,ATP2B4,SLC12A2,SLC43A2,ABCC2,ADD1,PEX3,SLC6A11,CFTR,PSMD12,SLC16A10,FTL,GNB3,GNGT2,ATP1B1,NUP37,RAF1,ATP6V0E1,SLC32A1,SLC25A10,SLC22A17,HMOX2,AQP2,CYBRD1,FTH1,STOML3,PSMD10,GNG13,EIF2S2,GNG5,TRPC1,GABRG2,SLCO3A1,ABCC5,SLC1A1,PSMD4,AQP4,TUSC3,ABCB1,PSMA1,EIF2S1,SLC35A1,AQP11,SLC16A1,NUP62,STOM,SLC35A2,SLC6A2,SLC25A26,NUP42,TF,PSMB2,PSMD1,SLC22A8,SLC20A1,SLC13A5,LCN15,GNG11,PSMC1,SLC2A3,ANKH,AQP3,SLC2A1,SLC39A7,CLIC2,PRKACB,SLC38A1,SLC6A6,SLC7A1,SLC1A3,DERL2,GNG2,ATP6V1E2,PLN,PSMD7,SLC6A12,RAB11A,GLRA1,SLC37A4,PSMB10,SLC30A7,PSMC5,ABCB9,NIPA2,ADCY3,PSMB5,PSMA3,OS9,PSMB7,PSMD3,FKBP1B,SLC1A2,NUP35,SLC35B4,GNB4,SRI,SLC45A3,SLC15A2,RHBG,SLC41A1,PSMD6,PSME2,GABRA2,GNG3,NUP107,ATP1A2,SLC39A10,SLC4A8,GLRA2,WWP1,ATP6V0B,SLCO2B1,OSTM1,ERLIN1,CLCA1,ADD2,SLC31A1,GLRB,GNB1,UBA52,ATP1B3,UNC79,ASIC1,MCOLN1,SLC6A3,KCNJ11,GABRB2,SLC39A3,PSMB3,ATP6V1C1,PSMA5,GNG10,TFRC,ERLEC1,SLC38A3,SLC5A6,ERLIN2,LCN1,RPS27A,ATP1A1,LCN12,PSMC3,SLC22A12,TSC22D3,ABCE1,SEM1,ATP6V1D,SLCO1B3,PSMB4,ATP6V1A,GABRB3,ASIC2,AZGP1,PSMA6,SLC7A8,ATP6V1G2,SLCO1A2,SLC7A9,FXYD6,CLCN6,ATP1A3,SLC38A2,SLC30A5,SLC35C1,SLC7A11,SLC11A2,SLC20A2,CAMK2G,DERL1,ANO3,RNASEL,G6PC3
R-HSA-6788467	IL-6-type cytokine receptor ligand interactions	0.635912476025337	-0.452694341424371	20	6	0.00185816042118303	3229	10285	3572,3592,1271,3717,3716,5008	IL6ST,IL12A,CNTFR,JAK2,JAK1,OSM
R-HSA-6802949	Signaling by RAS mutants	0.636355324845906	-0.451998184784785	50	15	0.00464540105295757	3229	10285	7450,7529,6714,3717,5245,5037,5894,5906,8315,1445,5604,3845,3265,4296,5908	VWF,YWHAB,SRC,JAK2,PHB1,PEBP1,RAF1,RAP1A,BRAP,CSK,MAP2K1,KRAS,HRAS,MAP3K11,RAP1B
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.643378633411868	-0.441021873600463	70	21	0.0065035614741406	3229	10285	9972,23636,7266,6119,9532,79023,51501,10762,57805,10049,3312,3309,129401,11097,9531,51182,57122,6118,6767,27000,6782	NUP153,NUP62,DNAJC7,RPA3,BAG2,NUP37,HIKESHI,NUP50,CCAR2,DNAJB6,HSPA8,HSPA5,NUP35,NUP42,BAG3,HSPA14,NUP107,RPA2,ST13,DNAJC2,HSPA13
R-HSA-1483257	Phospholipid metabolism	0.643763928017285	-0.440423191483235	207	63	0.0195106844224218	3229	10285	117245,5294,55224,8394,63874,126282,51205,3631,5728,79153,51573,55349,5322,8443,5295,375,3636,10162,51763,1460,5296,4952,79626,9489,11145,50640,22908,56623,25816,56910,51552,10554,388121,114882,90809,6901,5290,100137049,5867,79837,1120,57678,4534,55697,9791,8503,9896,55326,81579,84725,114971,23646,43,10423,1457,9107,5868,23760,8904,85465,9468,8898,3030	PLAAT5,PIK3CG,ETNK2,PIP5K1A,ABHD4,TNFAIP8L1,ACP6,INPP4A,PTEN,GDPD3,GDE1,CHDH,PLA2G5,GNPAT,PIK3R1,ARF1,INPPL1,LPCAT3,INPP5K,CSNK2B,PIK3R2,OCRL,TNFAIP8L2,PGS1,PLAAT3,PNPLA8,SACM1L,INPP5E,TNFAIP8,STARD7,RAB14,AGPAT1,TNFAIP8L3,OSBPL8,PIP4P1,TAFAZZIN,PIK3CA,PLA2G4B,RAB4A,PIP4K2C,CHKB,GPAM,MTM1,VAC14,PTDSS1,PIK3R3,FIG4,AGPAT5,PLA2G12A,PLEKHA8,PTPMT1,PLD3,ACHE,CDIPT,CSNK2A1,MTMR6,RAB5A,PITPNB,CPNE1,SELENOI,PCYT1B,MTMR2,HADHA
R-HSA-77387	Insulin receptor recycling	0.648881684270271	-0.432504883565866	27	8	0.00247754722824404	3229	10285	9550,534,90423,8992,51382,528,533,523	ATP6V1G1,ATP6V1G2,ATP6V1E2,ATP6V0E1,ATP6V1D,ATP6V1C1,ATP6V0B,ATP6V1A
R-HSA-209968	Thyroxine biosynthesis	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	1735,1734,1733	DIO3,DIO2,DIO1
R-HSA-8866904	Negative regulation of activity of TFAP2 (AP-2) family transcription factors	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	7341,79047,7329	SUMO1,KCTD15,UBE2I
R-HSA-2046105	Linoleic acid (LA) metabolism	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	9415,64834,83401	FADS2,ELOVL1,ELOVL3
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	8905,8907,567	AP1S2,AP1M1,B2M
R-HSA-73929	Base-Excision Repair, AP Site Formation	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	4968,23583,4350	OGG1,SMUG1,MPG
R-HSA-975578	Reactions specific to the complex N-glycan synthesis pathway	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	2530,3972,9486	FUT8,LHB,CHST10
R-HSA-5687613	Diseases associated with surfactant metabolism	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	6441,653509,6440	SFTPD,SFTPA1,SFTPC
R-HSA-1300644	Interaction With The Zona Pellucida	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	2683,5016,8747	B4GALT1,OVGP1,ADAM21
R-HSA-1250342	PI3K events in ERBB4 signaling	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	1839,5290,5295	HBEGF,PIK3CA,PIK3R1
R-HSA-450341	Activation of the AP-1 family of transcription factors	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	5602,2353,3725	MAPK10,FOS,JUN
R-HSA-77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	3033,3030,35	HADH,HADHA,ACADS
R-HSA-8868766	rRNA processing in the mitochondrion	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	51106,29960,3028	TFB1M,MRM2,HSD17B10
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	11163,11165,9807	NUDT4,NUDT3,IP6K1
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	57181,7922,29985	SLC39A10,SLC39A7,SLC39A3
R-HSA-74259	Purine catabolism	0.653653349900829	-0.425178114072187	10	3	0.000929080210591514	3229	10285	22978,4860,2876	NT5C2,PNP,GPX1
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	0.658504871234724	-0.417783360355056	17	5	0.00154846701765252	3229	10285	818,2891,4747,1742,2890	CAMK2G,GRIA2,NEFL,DLG4,GRIA1
R-HSA-5625900	RHO GTPases activate CIT	0.658504871234724	-0.417783360355056	17	5	0.00154846701765252	3229	10285	1027,1742,103910,388,4637	CDKN1B,DLG4,MYL12B,RHOB,MYL6
R-HSA-189445	Metabolism of porphyrins	0.658504871234724	-0.417783360355056	17	5	0.00154846701765252	3229	10285	3163,54658,1352,644,3145	HMOX2,UGT1A1,COX10,BLVRA,HMBS
R-HSA-435354	Zinc transporters	0.658504871234724	-0.417783360355056	17	5	0.00154846701765252	3229	10285	7922,64924,148867,29985,57181	SLC39A7,SLC30A5,SLC30A7,SLC39A3,SLC39A10
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	0.658504871234724	-0.417783360355056	17	5	0.00154846701765252	3229	10285	54512,11340,51013,80349,51010	EXOSC4,EXOSC8,EXOSC1,SKIC8,EXOSC3
R-HSA-1296072	Voltage gated Potassium channels	0.659211189250121	-0.416711326547131	44	13	0.00402601424589656	3229	10285	56479,3752,3756,3745,3746,3787,131096,3737,3751,3738,3754,7881,170850	KCNQ5,KCND3,KCNH1,KCNB1,KCNC1,KCNS1,KCNH8,KCNA2,KCND2,KCNA3,KCNF1,KCNAB1,KCNG3
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.660840290353481	-0.414243086549525	34	10	0.00309693403530505	3229	10285	79023,10189,10762,1977,9972,23636,11097,129401,57122,22916	NUP37,ALYREF,NUP50,EIF4E,NUP153,NUP62,NUP42,NUP35,NUP107,NCBP2
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.660840290353481	-0.414243086549525	34	10	0.00309693403530505	3229	10285	79023,5901,10762,129401,23636,11097,9972,5902,57122,7514	NUP37,RAN,NUP50,NUP35,NUP62,NUP42,NUP153,RANBP1,NUP107,XPO1
R-HSA-2299718	Condensation of Prophase Chromosomes	0.663665839293498	-0.409976510256594	74	22	0.00681325487767111	3229	10285	8335,85236,891,3015,983,94239,8350,474382,54892,3013,8342,8970,10051,79648,8345,255626,55766,8334,3014,5925,8331,8348	H2AC4,H2BC12,CCNB1,H2AZ1,CDK1,H2AZ2,H3C1,H2AB1,NCAPG2,H2AC7,H2BC14,H2BC11,SMC4,MCPH1,H2BC9,H2BC1,H2AJ,H2AC6,H2AX,RB1,H2AC14,H2BC17
R-HSA-171052	LDL-mediated lipid transport	0.667106064302117	-0.404806228763665	24	7	0.00216785382471353	3229	10285	3988,255738,1175,3949,10577,160,1173	LIPA,PCSK9,AP2S1,LDLR,NPC2,AP2A1,AP2M1
R-HSA-5663220	RHO GTPases Activate Formins	0.669015576657275	-0.40194793563128	117	35	0.0108392691235677	3229	10285	79003,5518,5501,23002,6396,348235,5048,91687,619553,83540,6714,79019,79980,7514,57122,4085,9184,22919,5529,401541,3796,388,5516,147841,5525,60,10403,998,332,991,54820,1856,220134,79023,80776	MIS12,PPP2R1A,PPP1CC,DAAM1,SEC13,SKA2,PAFAH1B1,CENPL,MIR484,NUF2,SRC,CENPM,DSN1,XPO1,NUP107,MAD2L1,BUB3,MAPRE1,PPP2R5E,CENPP,KIF2A,RHOB,PPP2CB,SPC24,PPP2R5A,ACTB,NDC80,CDC42,BIRC5,CDC20,NDE1,DVL2,SKA1,NUP37,B9D2
R-HSA-171306	Packaging Of Telomere Ends	0.670614985702958	-0.399560098490839	51	15	0.00464540105295757	3229	10285	94239,474382,3013,85236,8335,3015,255626,55766,8334,3014,8348,8331,8342,8970,8345	H2AZ2,H2AB1,H2AC7,H2BC12,H2AC4,H2AZ1,H2BC1,H2AJ,H2AC6,H2AX,H2BC17,H2AC14,H2BC14,H2BC11,H2BC9
R-HSA-418990	Adherens junctions interactions	0.676386698130293	-0.390990327836635	31	9	0.00278724063177454	3229	10285	1499,1500,1495,1005,5819,1009,1006,1012,3728	CTNNB1,CTNND1,CTNNA1,CDH7,NECTIN2,CDH11,CDH8,CDH13,JUP
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.676386698130293	-0.390990327836635	31	9	0.00278724063177454	3229	10285	11097,23636,129401,9972,7514,57122,79023,5901,10762	NUP42,NUP62,NUP35,NUP153,XPO1,NUP107,NUP37,RAN,NUP50
R-HSA-379398	Enzymatic degradation of Dopamine by monoamine oxidase	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	1312	COMT
R-HSA-1296067	Potassium transport channels	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	3766	KCNJ10
R-HSA-964827	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	10905	MAN1A2
R-HSA-1483248	Synthesis of PIPs at the ER membrane	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	22908	SACM1L
R-HSA-8849472	PTK6 Down-Regulation	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	5770	PTPN1
R-HSA-73843	5-Phosphoribose 1-diphosphate biosynthesis	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	5631	PRPS1
R-HSA-193681	Ceramide signalling	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	6610	SMPD2
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	8655	DYNLL1
R-HSA-5339700	TCF7L2 mutants don't bind CTBP	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	1487	CTBP1
R-HSA-1368071	NR1D1 (REV-ERBA) represses gene expression	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	8841	HDAC3
R-HSA-8875791	MET activates STAT3	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	4233	MET
R-HSA-162699	Synthesis of dolichyl-phosphate mannose	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	8818	DPM2
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	10642	IGF2BP1
R-HSA-1299503	TWIK related potassium channel (TREK)	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	54207	KCNK10
R-HSA-165181	Inhibition of TSC complex formation by PKB	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	208	AKT2
R-HSA-379397	Enzymatic degradation of dopamine by COMT	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	1312	COMT
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	3030	HADHA
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	3030	HADHA
R-HSA-265473	Trafficking of dietary sterols	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	29881	NPC1L1
R-HSA-3296197	Hydroxycarboxylic acid-binding receptors	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	27198	HCAR1
R-HSA-380615	Serotonin clearance from the synaptic cleft	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	6532	SLC6A4
R-HSA-844615	The AIM2 inflammasome	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	29108	PYCARD
R-HSA-5627083	RHO GTPases regulate CFTR trafficking	0.67714698554459	-0.389866916571105	3	1	0.000309693403530505	3229	10285	1080	CFTR
R-HSA-419408	Lysosphingolipid and LPA receptors	0.686271544997456	-0.376481891390808	14	4	0.00123877361412202	3229	10285	8698,9170,54886,1902	S1PR4,LPAR2,PLPPR1,LPAR1
R-HSA-1250347	SHC1 events in ERBB4 signaling	0.686271544997456	-0.376481891390808	14	4	0.00123877361412202	3229	10285	3265,6464,1839,3845	HRAS,SHC1,HBEGF,KRAS
R-HSA-418885	DCC mediated attractive signaling	0.686271544997456	-0.376481891390808	14	4	0.00123877361412202	3229	10285	6714,8976,4690,998	SRC,WASL,NCK1,CDC42
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.686271544997456	-0.376481891390808	14	4	0.00123877361412202	3229	10285	7157,208,207,10000	TP53,AKT2,AKT1,AKT3
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.686271544997456	-0.376481891390808	14	4	0.00123877361412202	3229	10285	5162,1737,5160,57546	PDHB,DLAT,PDHA1,PDP2
R-HSA-190322	FGFR4 ligand binding and activation	0.686271544997456	-0.376481891390808	14	4	0.00123877361412202	3229	10285	8823,8074,8822,2246	FGF16,FGF23,FGF17,FGF1
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.688071323745934	-0.373862778186604	21	6	0.00185816042118303	3229	10285	354,3486,2147,5340,3487,3479	KLK3,IGFBP3,F2,PLG,IGFBP4,IGF1
R-HSA-3000480	Scavenging by Class A Receptors	0.688071323745934	-0.373862778186604	21	6	0.00185816042118303	3229	10285	1278,811,2495,7184,2512,1281	COL1A2,CALR,FTH1,HSP90B1,FTL,COL3A1
R-HSA-8849932	SALM protein interactions at the synapses	0.688071323745934	-0.373862778186604	21	6	0.00185816042118303	3229	10285	1741,79414,2890,1739,10211,1742	DLG3,LRFN3,GRIA1,DLG1,FLOT1,DLG4
R-HSA-162582	Signal Transduction	0.690682234958522	-0.370075423561806	2547	790	0.244657788789099	3229	10285	7529,2239,27248,120586,2171,2911,1902,7480,54106,528,5691,84986,8630,5037,7525,23236,390093,6375,134864,5048,55843,10817,9475,1852,390261,441608,219858,6016,5899,23002,4088,6396,5436,390431,8323,2781,818,134083,8405,1024,2773,534,8829,6610,3315,220,30851,10653,51382,7422,1382,1845,5870,5770,84455,219437,5368,5996,7157,942,8334,1394,1027,392138,1385,51109,5295,8350,6363,55081,680,1742,25999,5330,406975,9938,8348,147841,6869,90423,8822,941,63916,26686,5536,26523,341152,3952,5664,10810,259286,4738,9628,390059,26692,1132,7867,1173,5438,2921,4086,51098,200734,4615,8550,83888,5530,3480,4747,3949,1909,3577,26493,64399,6366,5145,2887,50837,2002,8394,51107,1874,153,4790,3726,4233,2787,6658,10616,595,4659,27006,50838,2963,390195,10013,5707,23768,10787,50865,6778,23767,896,25780,11245,80346,5957,441669,442186,219981,5682,187,390265,55789,5704,991,5689,10768,5694,390260,3355,6009,7289,5028,5685,120775,1215,5433,5441,6776,7124,5732,5781,50833,3716,119772,5596,8698,7253,79023,5579,2784,1437,53358,4987,57728,10252,2776,7349,26534,6667,3559,5142,4992,329,1812,390429,6368,319100,3673,10325,3728,9040,6870,8331,4296,4193,9249,1375,5030,5340,56998,6242,22943,119692,2017,4983,26574,56957,50848,2033,7074,2255,23072,138802,5997,84292,7015,10094,8870,119765,23493,659,10000,1235,28956,10457,26999,7932,5564,114814,5021,161742,367,81696,5693,109,81285,2859,58480,1020,8658,6696,11108,4087,553,90627,1524,283694,6385,6014,9958,79980,5567,3576,4952,219865,1232,533,3015,2771,23322,2252,50964,1026,4205,84904,22919,94134,7476,29127,8887,11059,7088,5880,80351,390648,1839,219983,64805,11167,7029,9283,8878,84152,54429,64837,79924,60,3185,382,9021,51764,442361,57381,5162,8490,5431,285440,6093,155,57142,1454,55366,2550,390162,5700,145226,7432,5690,8682,5516,57154,9630,3796,60436,619553,91687,9982,6464,5173,5948,3562,4988,5245,3569,6657,259292,1460,4853,3717,341418,283869,154,4974,4915,1393,9184,51517,50999,4986,122706,91851,6364,85236,9550,338675,9101,339745,2280,221472,5518,390433,2788,219959,57610,390199,6346,7128,9350,403253,6788,79577,9170,4889,9886,7532,1975,8862,5698,10193,10888,7059,7189,134,7976,2931,7185,9402,2918,1457,4887,998,29851,160,3356,1977,121130,356,2790,5686,27043,10798,1124,7534,4792,1133,6373,6714,103910,7450,3953,2796,55851,26533,8823,26160,474382,151306,3350,6655,3815,3567,2775,79837,9227,1843,4040,22916,2683,338328,170589,5501,81847,6233,5150,7323,857,4295,6863,10911,90268,2817,9241,1500,121364,940,8315,1445,1785,399,3725,3558,84539,23385,8477,8322,26211,5578,51009,3060,10750,2833,4609,219954,10014,60485,466,51719,8503,5744,50855,6772,1452,57122,4637,441670,1175,79885,3178,3274,23173,5721,10273,79003,11221,10126,10988,255626,10161,1848,5296,3561,221035,8342,26020,152559,29967,1737,54886,57690,607,5539,3845,1234,4089,5898,658,6484,8452,23118,80776,5045,1856,27334,207,5290,4085,3320,729230,5432,6387,406974,27018,3361,283297,30817,219870,3913,7410,256933,7852,5683,79290,219875,108,57406,2260,117579,6019,6376,6711,5896,9844,284,5153,3516,390152,10642,10213,5435,8607,26648,195814,92840,2793,5581,51306,2962,64388,3014,7072,130399,10663,2622,2838,9146,26090,5241,8743,3627,2847,8345,6370,572,23543,6352,391,6285,5525,2797,10589,5136,1814,5529,56477,8074,5160,118788,2831,125958,7311,10850,113091,2782,10235,7048,5588,5908,2665,5734,344,283162,4886,1272,4093,3560,140,2925,10268,1233,5687,2549,388,390157,79544,7979,83540,9559,3972,1128,5692,523,80834,2912,11255,100126338,355,5702,2861,7186,5684,2919,3292,7276,441639,219431,5709,10287,125963,5695,219986,387129,10956,4829,5737,259285,64108,5705,2810,5699,6383,5713,54331,6789,6500,6794,1131,84447,867,59349,122042,989,120787,55004,390437,3013,6662,1645,2342,94239,5906,2785,354,392,5867,79019,7321,9861,348235,59345,5138,9459,332,10454,23028,2246,54820,6709,55437,10097,1592,5728,6001,4343,6258,4318,5716,26339,6750,8992,6850,7533,5500,5894,2767,728635,442191,5151,2147,5032,5604,157506,10403,124,1387,8724,5571,1025,8649,3265,2791,51684,8841,1268,11197,394,4283,4852,8335,3551,5062,1495,3685,5710,10602,2837,1499,10109,1230,124538,1019,220134,10435,1399,84432,8970,5294,7424,4090,7433,55970,4690,983,5720,3479,1487,7314,91,4208,7472,10563,9099,10901,390436,5731,5718,1080,4771,8976,657,27198,10670,401666,3572,7514,219960,401541,1236,55766,208,55294,2248,57007,6422,148,57584,51738,64130,2840	YWHAB,GPC4,ERLEC1,OR8I2,FABP5,GRM1,LPAR1,WNT10B,TLR9,ATP6V1C1,PSMB3,ARHGAP19,HSD17B6,PEBP1,YES1,PLCB1,OR10A6,XCL1,TAAR1,PAFAH1B1,ARHGAP15,FRS3,ROCK2,DUSP9,OR6M1,OR5B3,OR8B12,RIT1,RALB,DAAM1,SMAD3,SEC13,POLR2G,OR4K2,FZD6,GNAZ,CAMK2G,OR2Y1,SPOP,CDK8,GNAI3,ATP6V1G2,NRP1,SMPD2,HSPB1,ALDH1A3,TAX1BP3,SPINT2,ATP6V1D,VEGFA,CRABP2,DUSP3,RAB6A,PTPN1,EFCAB7,OR5L1,PNOC,RGS1,TP53,CD86,H2AC6,CRHR1,CDKN1B,OR2A25,CREB1,RDH11,PIK3R1,H3C1,CCL19,IFT57,BRS3,DLG4,CLIP3,PLCB2,MIR198,ARHGAP25,H2BC17,SPC24,TACR1,ATP6V1E2,FGF17,CD80,ELMO2,OR4E2,PPP5C,AGO1,OR2AT4,LEP,PSEN2,WASF3,TAS2R40,NEDD8,RGS6,OR51M1,OR2W1,CHRM4,MAPKAPK3,AP2M1,POLR2I,CXCL3,SMAD1,IFT52,SPRED2,MYD88,MAPKAPK5,FGFBP2,PPP3CA,IGF1R,NEFL,LDLR,EDNRA,CXCR1,OR8B8,HHIP,CCL21,PDE6A,GRB10,TAS2R7,ELK1,PIP5K1A,APH1A,E2F4,ADRB1,NFKB1,JUNB,MET,GNG5,SOX3,RBCK1,CCND1,PPP1R12A,FGF22,TAS2R13,GTF2F2,OR5AN1,HDAC6,PSMD1,FLRT2,NCKAP1,HEBP1,STAT6,FLRT3,CCND3,RASGRP3,GPR176,REEP4,RCVRN,OR4Q3,OR2J3,OR5A2,PSMA1,APLNR,OR10G7,DEPDC1B,PSMC4,CDC20,PSMB1,AHCYL1,PSMB6,OR6X1,HTR1F,RHEB,TULP3,P2RY1,PSMA4,OR2D3,CMA1,POLR2D,POLR2L,STAT5A,TNF,PTGER2,PTPN11,TAS2R16,JAK1,OR52M1,MAPK4,S1PR4,TSHR,NUP37,PRKCB,GNB3,CSF2,SHC3,OPRL1,WDR19,SPRY1,GNAQ,UCN,OR10G2,SP1,IL2RA,PDE4B,OR1F1,BIRC2,DRD1,OR4N2,CCL23,TAAR6,ITGA2,RRAGB,JUP,UBE2M,TACR3,H2AC14,MAP3K11,MDM2,DHRS3,CPT1B,P2RY4,PLG,CTNNBIP1,RTKN,DKK1,OR51S1,CTTN,OPHN1,AATF,OTUD7B,F11R,EP300,TIAM1,FGF10,HECW1,OR13C8,RGS2,WDR83,TERT,ARPC3,IER3,OR4B1,HEY2,BMPR2,AKT3,CCR6,LAMTOR2,GPNMB,CYFIP2,OR2H2,PRKAB1,GNRHR2,OXTR,SPRED1,AR,OR5V1,PSMB5,ADCY3,OR51E2,GPR35,RHOU,CDK5,TNKS,SPP1,PRDM4,SMAD2,AVPR1B,STARD13,CX3CR1,OR4N4,SDC4,RIT2,USP15,DSN1,PRKACB,CXCL8,OCRL,OR8G5,CCR3,ATP6V0B,H2AZ1,GNAI2,RPGRIP1L,FGF7,SOST,CDKN1A,MEF2A,ARHGEF39,MAPRE1,ARHGAP12,WNT7A,RACGAP1,TAX1BP1,WWP1,TLE1,RAC2,TNKS2,OR4F6,HBEGF,OR4D6,P2RY12,FSTL1,TFDP2,GPR37L1,SQSTM1,PPP1R1B,TAS2R5,KLC2,ADM2,ACTB,HNRNPF,ARF6,SOCS3,GNG13,OR2A2,RHOJ,PDHB,RGS5,POLR2B,CYP4V2,ROCK1,ADRB3,RTN4,CSNK1E,LGR4,GABBR1,OR5M9,PSMC1,RDH12,VIP,PSMB2,PEA15,PPP2CB,SMURF1,GNA14,KIF2A,TGIF2,MIR484,CENPL,FGFBP1,SHC1,PDYN,RBP2,IL3,OPRM1,PHB1,IL6,SOX2,TAS2R46,CSNK2B,NOTCH2,JAK2,OR6C4,NPW,ADRB2,OMG,NTRK2,CRHBP,BUB3,NCKIPSD,TMED5,OPRK1,PSMB11,CHRDL1,CCL20,H2BC12,ATP6V1G1,OR5AP2,USP8,SPOPL,FKBP1A,FGD2,PPP2R1A,OR4K13,GNG7,OR1S1,RANBP10,OR4D9,CCL1,TNFAIP3,CER1,OR4A47,STK3,CDC73,LPAR2,NPY5R,RHOBTB1,YWHAG,EIF4B,APLN,PSMB9,RNF41,GPR83,THBS3,TRAF6,ADORA1,FZD3,GSK3A,TRAF1,GRAP2,GRM8,CSNK2A1,NPY2R,CDC42,ICOS,AP2A1,HTR2A,EIF4E,OR10P1,FASLG,GNG10,PSMA5,PELP1,OR5I1,CHN2,YWHAZ,NFKBIA,CHRM5,CXCL11,SRC,MYL12B,VWF,LEPR,GNRH1,PSENEN,OR10G3,FGF16,IFT172,H2AB1,GPBAR1,HTR1A,SOS2,KIT,IL5,GNAO1,PIP4K2C,LRAT,DUSP1,LRP6,NCBP2,B4GALT1,GPIHBP1,GPHA2,PPP1CC,RNF146,RPS27A,PDE7A,UBE2D3,CAV1,MLN,TAC1,UTS2,OTULIN,GPC1,NOG,CTNND1,OR10A7,CD28,BRAP,CSK,DNM2,RHOH,JUN,IL2,MCHR2,NCSTN,GPR65,FZD4,OR2F1,PRKCA,DERL2,HCRT,GRAP,CXCR3,MYC,OR9I1,HDAC5,SAV1,ATF1,CAB39,PIK3R3,PTHLH,PARD6A,STAT1,CSNK1A1,NUP107,MYL6,OR4M1,AP2S1,HDAC11,HNRNPA1,HRH2,METAP1,PSME2,STUB1,MIS12,DUSP10,DNAL4,METAP2,H2BC1,LPAR6,DUSP6,PIK3R2,IL2RG,REEP3,H2BC14,LRP10,PAQR3,LRP12,DLAT,PLPPR1,TNRC6C,BCL9,PPY,KRAS,CCR5,SMAD4,RALA,BMPR1B,ST3GAL4,CUL3,TAB2,B9D2,FURIN,DVL2,P2RY10,AKT1,PIK3CA,MAD2L1,HSP90AA1,CCR2,POLR2C,CXCL12,MIR197,BEX3,HTR5A,OR10A4,ADGRE2,OR10G9,LAMB2,VAV2,NPB,CXCR4,PSMA2,OR13A1,OR4D5,ADCY2,ABHD6,FGFR1,RLN3,RLN2,CX3CL1,SPTBN1,RAG1,ELMO1,ANGPT1,PDE1B,RBPJ,OR8H3,IGF2BP1,PSMD14,POLR2F,RUVBL1,OR7E24,SDR16C5,REEP6,GNGT2,PRKCE,FAM13B,GTF2F1,GREM2,H2AX,TIA1,ACVR1C,CXCR6,GAS8,GPR15,HGS,ABHD12,PGR,TNFSF10,CXCL10,MCHR1,H2BC9,CCL25,BAD,RBFOX2,CCL5,RHOG,S100B,PPP2R5A,GNRH2,DRAP1,PDE1A,DRD3,PPP2R5E,CCL28,FGF23,PDHA1,PIK3AP1,NPBWR1,OR7D4,UBA52,CCL27,PTH2,GNB1,RASGRP2,TGFBR2,PRKCQ,RAP1B,GDI2,PTGER4,APOC2,OR8B4,NPY1R,CNTN1,SMAD9,IL2RB,ADORA3,GRPR,RAMP3,CCR4,PSMA6,GAB1,RHOB,OR8K1,OR4K1,SEM1,NUF2,VPS26A,LHB,CHRM1,PSMB4,ATP6V1A,TAS1R2,GRM2,HRH3,MIR937,FAS,PSMC3,GPR37,TRAF2,PSMA3,CXCL1,HSD17B1,TTR,OR9K2,OR4S2,PSMD3,RGS19,OR1M1,PSMB7,OR4D11,NPSR1,OS9,NMBR,PTGFR,TAS2R39,RTP4,PSMC5,SFN,PSMB10,SDC2,PSMD7,GNG2,STK4,SKP1,STK11,CHRM3,SYVN1,CBL,KLHL12,RXFP2,SEPTIN7,OR52W1,LAMTOR1,OR4N5,H2AC7,SOX9,AKR1C1,FNTB,H2AZ2,RAP1A,GNG3,KLK3,ARHGAP1,RAB4A,CENPM,UBE2D1,PSMD6,SKA2,GNB4,PDE2A,ARHGEF6,BIRC5,TAB1,KDM1A,FGF1,NDE1,SPTAN1,STRADB,ACTR2,CYP26A1,PTEN,RGS10,MOV10,RXRG,MMP9,PSMD10,OR5K1,SST,ATP6V0E1,SYK,YWHAH,PPP1CB,RAF1,GNA11,DHRS4L1,OR14J1,PDE8A,F2,P2RY11,MAP2K1,RDH10,NDC80,ADH1A,CREBBP,SNX3,PRKAG1,CDK9,LAMTOR3,HRAS,GNG11,SUFU,HDAC3,CNR1,WIF1,ARHGAP5,CXCL9,NPY,H2AC4,IKBKB,PAK2,CTNNA1,ITGAV,PSMD4,CDC42EP3,UTS2R,CTNNB1,ARPC2,CCR1,OR4D2,CDK4,SKA1,CDC42EP2,CRKL,PROK1,H2BC11,PIK3CG,VEGFC,SMAD5,VIPR1,GNG12,NCK1,CDK1,PSME1,IGF1,CTBP1,UBB,ACVR1B,MEF2C,WNT2,CXCL13,USP2,DHRS4,OR4K17,PTGER1,PSMD12,CFTR,NF2,WASL,BMPR1A,HCAR1,RRAGA,OR51A4,IL6ST,XPO1,OR10Q1,CENPP,CCR7,H2AJ,AKT2,FBXW7,FGF3,ACKR3,SFRP1,ADRA1A,ARHGAP21,GHRL,LIN7B,GPR17
R-HSA-437239	Recycling pathway of L1	0.693645256271062	-0.365794607272038	28	8	0.00247754722824404	3229	10285	1785,3897,1175,6714,8986,1173,160,4478	DNM2,L1CAM,AP2S1,SRC,RPS6KA4,AP2M1,AP2A1,MSN
R-HSA-190828	Gap junction trafficking	0.693645256271062	-0.365794607272038	28	8	0.00247754722824404	3229	10285	84694,2697,1173,4646,1785,2705,10052,2706	GJA10,GJA1,AP2M1,MYO6,DNM2,GJB1,GJC1,GJB2
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.694484139830029	-0.364585953866316	45	13	0.00402601424589656	3229	10285	1385,56652,5465,200186,8841,2553,1387,6604,506,4208,51106,6742,2551	CREB1,TWNK,PPARA,CRTC2,HDAC3,GABPB1,CREBBP,SMARCD3,ATP5F1B,MEF2C,TFB1M,SSBP1,GABPA
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	5516,5518	PPP2CB,PPP2R1A
R-HSA-6814848	Glycerophospholipid catabolism	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	79153,51573	GDPD3,GDE1
R-HSA-174362	Transport and synthesis of PAPS	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	51000,9060	SLC35B3,PAPSS2
R-HSA-5619102	SLC transporter disorders	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	553,213	AVPR1B,ALB
R-HSA-196791	Vitamin D (calciferol) metabolism	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	1594,120227	CYP27B1,CYP2R1
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	4609,1499	MYC,CTNNB1
R-HSA-199920	CREB phosphorylation	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	1385,466	CREB1,ATF1
R-HSA-162791	Attachment of GPI anchor to uPAR	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	10026,8733	PIGK,GPAA1
R-HSA-426496	Post-transcriptional silencing by small RNAs	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	57690,26523	TNRC6C,AGO1
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	3516,6928	RBPJ,HNF1B
R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	148867,64924	SLC30A7,SLC30A5
R-HSA-196843	Vitamin B2 (riboflavin) metabolism	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	54,113278	ACP5,SLC52A3
R-HSA-190371	FGFR3b ligand binding and activation	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	2246,8822	FGF1,FGF17
R-HSA-5652084	Fructose metabolism	0.699424591468107	-0.35749729416443	7	2	0.00061938680706101	3229	10285	231,6652	AKR1B1,SORD
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.700277279094315	-0.356278909378894	82	24	0.00743264168473212	3229	10285	11258,7532,55142,22919,203068,3320,8636,54820,4751,80321,7846,891,1781,7283,8655,5518,1454,983,10121,619553,95681,10383,1069,5048	DCTN3,YWHAG,HAUS2,MAPRE1,TUBB,HSP90AA1,SSNA1,NDE1,NEK2,CEP70,TUBA1A,CCNB1,DYNC1I2,TUBG1,DYNLL1,PPP2R1A,CSNK1E,CDK1,ACTR1A,MIR484,CEP41,TUBB4B,CETN2,PAFAH1B1
R-HSA-380287	Centrosome maturation	0.700277279094315	-0.356278909378894	82	24	0.00743264168473212	3229	10285	5518,8655,10383,1069,5048,10121,619553,95681,983,1454,3320,22919,203068,11258,7532,55142,891,1781,7283,4751,80321,7846,54820,8636	PPP2R1A,DYNLL1,TUBB4B,CETN2,PAFAH1B1,ACTR1A,MIR484,CEP41,CDK1,CSNK1E,HSP90AA1,MAPRE1,TUBB,DCTN3,YWHAG,HAUS2,CCNB1,DYNC1I2,TUBG1,NEK2,CEP70,TUBA1A,NDE1,SSNA1
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.700455159692049	-0.356024927113953	35	10	0.00309693403530505	3229	10285	79023,10189,10762,23636,11097,129401,1977,9972,22916,57122	NUP37,ALYREF,NUP50,NUP62,NUP42,NUP35,EIF4E,NUP153,NCBP2,NUP107
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.705846625007175	-0.348357310122345	122	36	0.0111489625270982	3229	10285	441024,2350,1528,440387,166785,81034,1727,60496,113278,6515,9962,9446,6470,6513,25974,119391,8884,5096,55163,83594,54,10560,31,10243,316,79178,10588,4594,80704,10840,54981,5091,952,5644,27249,55788	MTHFD2L,FOLR2,CYB5A,CTRB2,MMAA,SLC25A32,CYB5R3,AASDHPPT,SLC52A3,SLC2A3,SLC23A2,GSTO1,SHMT1,SLC2A1,MMACHC,GSTO2,SLC5A6,PCCB,PNPO,NUDT12,ACP5,SLC19A2,ACACA,GPHN,AOX1,THTPA,MTHFS,MMUT,SLC19A3,ALDH1L1,NMRK1,PC,CD38,PRSS1,MMADHC,LMBRD1
R-HSA-168253	Host Interactions with Influenza Factors	0.707648868884162	-0.345807256214982	42	12	0.00371632084236606	3229	10285	9972,9636,23636,3838,79023,3836,5610,10762,11097,129401,57122,10898	NUP153,ISG15,NUP62,KPNA2,NUP37,KPNA1,EIF2AK2,NUP50,NUP42,NUP35,NUP107,CPSF4
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	0.707836915483331	-0.345541557184512	132	39	0.0120780427376897	3229	10285	8970,6118,8342,7341,9025,5425,116028,7336,3014,8348,6613,548593,7334,56655,80010,29086,57804,11073,5982,7314,5932,5984,890,7311,8345,5531,6233,9656,255626,5111,54107,85236,5983,7329,672,4683,5985,5810,6119	H2BC11,RPA2,H2BC14,SUMO1,RNF8,POLD2,RMI2,UBE2V2,H2AX,H2BC17,SUMO2,SLX1A,UBE2N,POLE4,RMI1,BABAM1,POLD4,TOPBP1,RFC2,UBB,RBBP8,RFC4,CCNA2,UBA52,H2BC9,PPP4C,RPS27A,MDC1,H2BC1,PCNA,POLE3,H2BC12,RFC3,UBE2I,BRCA1,NBN,RFC5,RAD1,RPA3
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.709309844387926	-0.343462831851762	69	20	0.0061938680706101	3229	10285	8970,8342,7341,8345,9025,9656,255626,27343,3014,7336,8348,85236,64421,7334,4683,672,55775,29086,7520,79840	H2BC11,H2BC14,SUMO1,H2BC9,RNF8,MDC1,H2BC1,POLL,H2AX,UBE2V2,H2BC17,H2BC12,DCLRE1C,UBE2N,NBN,BRCA1,TDP1,BABAM1,XRCC5,NHEJ1
R-HSA-1912420	Pre-NOTCH Processing in Golgi	0.712682029233428	-0.338719919842829	18	5	0.00154846701765252	3229	10285	4853,5870,2683,5045,6484	NOTCH2,RAB6A,B4GALT1,FURIN,ST3GAL4
R-HSA-1614635	Sulfur amino acid metabolism	0.713013389191585	-0.338255080074333	25	7	0.00216785382471353	3229	10285	55748,1468,7263,1036,84890,2729,4507	CNDP2,SLC25A10,TST,CDO1,ADO,GCLC,MTAP
R-HSA-182971	EGFR downregulation	0.713013389191585	-0.338255080074333	25	7	0.00216785382471353	3229	10285	9146,7314,10252,867,7311,998,6233	HGS,UBB,SPRY1,CBL,UBA52,CDC42,RPS27A
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.716701041415385	-0.333096482913158	32	9	0.00278724063177454	3229	10285	57122,7514,129401,23636,11097,9972,10762,5901,79023	NUP107,XPO1,NUP35,NUP62,NUP42,NUP153,NUP50,RAN,NUP37
R-HSA-1592389	Activation of Matrix Metalloproteinases	0.716701041415385	-0.333096482913158	32	9	0.00278724063177454	3229	10285	440387,4318,5340,5045,4323,1513,5644,1215,7076	CTRB2,MMP9,PLG,FURIN,MMP14,CTSK,PRSS1,CMA1,TIMP1
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.716701041415385	-0.333096482913158	32	9	0.00278724063177454	3229	10285	1499,5516,857,1856,5529,5518,5525,1452,4040	CTNNB1,PPP2CB,CAV1,DVL2,PPP2R5E,PPP2R1A,PPP2R5A,CSNK1A1,LRP6
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	0.717366351937559	-0.332168617775172	76	22	0.00681325487767111	3229	10285	8342,8970,11335,5928,55766,3014,8348,57504,3015,5931,8350,94239,474382,3013,53615,8345,255626,8334,8331,85236,8335,9219	H2BC14,H2BC11,CBX3,RBBP4,H2AJ,H2AX,H2BC17,MTA3,H2AZ1,RBBP7,H3C1,H2AZ2,H2AB1,H2AC7,MBD3,H2BC9,H2BC1,H2AC6,H2AC14,H2BC12,H2AC4,MTA2
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	0.721785125822079	-0.326027794048566	39	11	0.00340662743883555	3229	10285	6850,867,6786,7220,4690,80228,974,118788,6464,10768,5295	SYK,CBL,STIM1,TRPC1,NCK1,ORAI2,CD79B,PIK3AP1,SHC1,AHCYL1,PIK3R1
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.722018314021436	-0.325704774730355	11	3	0.000929080210591514	3229	10285	983,891,7283	CDK1,CCNB1,TUBG1
R-HSA-71182	Phenylalanine and tyrosine catabolism	0.722018314021436	-0.325704774730355	11	3	0.000929080210591514	3229	10285	5092,80150,2184	PCBD1,ASRGL1,FAH
R-HSA-73614	Pyrimidine salvage reactions	0.722018314021436	-0.325704774730355	11	3	0.000929080210591514	3229	10285	7371,1633,83549	UCK2,DCK,UCK1
R-HSA-68689	CDC6 association with the ORC:origin complex	0.722018314021436	-0.325704774730355	11	3	0.000929080210591514	3229	10285	5001,84515,23594	ORC5,MCM8,ORC6
R-HSA-5625970	RHO GTPases activate KTN1	0.722018314021436	-0.325704774730355	11	3	0.000929080210591514	3229	10285	998,64837,391	CDC42,KLC2,RHOG
R-HSA-446107	Type I hemidesmosome assembly	0.722018314021436	-0.325704774730355	11	3	0.000929080210591514	3229	10285	100126326,3655,977	MIR936,ITGA6,CD151
R-HSA-1980143	Signaling by NOTCH1	0.726361248837384	-0.319707799982883	73	21	0.0065035614741406	3229	10285	7088,3516,10013,7311,6233,1024,7314,23493,51107,10014,1272,5664,6500,79885,8841,4609,55851,2033,1387,55294,23385	TLE1,RBPJ,HDAC6,UBA52,RPS27A,CDK8,UBB,HEY2,APH1A,HDAC5,CNTN1,PSEN2,SKP1,HDAC11,HDAC3,MYC,PSENEN,EP300,CREBBP,FBXW7,NCSTN
R-HSA-195258	RHO GTPase Effectors	0.728233171643925	-0.317133991347897	294	88	0.0272530195106844	3229	10285	94239,3013,79023,8976,1080,4771,3015,401541,354,55766,4637,3014,7532,7514,57122,22919,79019,5880,255626,64837,8331,348235,79003,64130,8345,991,8350,220134,1027,2810,8348,147841,8970,1742,9184,51517,10810,79980,85236,4690,5518,474382,1856,80776,10403,10094,3796,26999,388,5516,30851,10787,4085,5062,1495,8335,91687,619553,83540,10109,8334,1499,367,5501,54820,6242,391,5525,60,7529,332,23028,998,10097,8342,2017,5529,6714,9475,103910,7534,6093,5048,6396,23002,5500,7533,4659	H2AZ2,H2AC7,NUP37,WASL,CFTR,NF2,H2AZ1,CENPP,KLK3,H2AJ,MYL6,H2AX,YWHAG,XPO1,NUP107,MAPRE1,CENPM,RAC2,H2BC1,KLC2,H2AC14,SKA2,MIS12,LIN7B,H2BC9,CDC20,H3C1,SKA1,CDKN1B,SFN,H2BC17,SPC24,H2BC11,DLG4,BUB3,NCKIPSD,WASF3,DSN1,H2BC12,NCK1,PPP2R1A,H2AB1,DVL2,B9D2,NDC80,ARPC3,KIF2A,CYFIP2,RHOB,PPP2CB,TAX1BP3,NCKAP1,MAD2L1,PAK2,CTNNA1,H2AC4,CENPL,MIR484,NUF2,ARPC2,H2AC6,CTNNB1,AR,PPP1CC,NDE1,RTKN,RHOG,PPP2R5A,ACTB,YWHAB,BIRC5,KDM1A,CDC42,ACTR2,H2BC14,CTTN,PPP2R5E,SRC,ROCK2,MYL12B,YWHAZ,ROCK1,PAFAH1B1,SEC13,DAAM1,PPP1CB,YWHAH,PPP1R12A
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.73187830726802	-0.312141025742985	100	29	0.00898110870238464	3229	10285	54820,27077,80776,8636,1781,7283,132320,23322,7846,80321,4751,55142,7532,11258,3320,203068,22919,983,1454,5048,1069,10383,95681,8766,619553,10121,8655,79598,5518	NDE1,B9D1,B9D2,SSNA1,DYNC1I2,TUBG1,SCLT1,RPGRIP1L,TUBA1A,CEP70,NEK2,HAUS2,YWHAG,DCTN3,HSP90AA1,TUBB,MAPRE1,CDK1,CSNK1E,PAFAH1B1,CETN2,TUBB4B,CEP41,RAB11A,MIR484,ACTR1A,DYNLL1,CEP97,PPP2R1A
R-HSA-1482839	Acyl chain remodelling of PE	0.734587246149361	-0.308446507373529	29	8	0.00247754722824404	3229	10285	10162,50640,100137049,11145,63874,5322,81579,117245	LPCAT3,PNPLA8,PLA2G4B,PLAAT3,ABHD4,PLA2G5,PLA2G12A,PLAAT5
R-HSA-1482801	Acyl chain remodelling of PS	0.735033152592601	-0.307839675218361	22	6	0.00185816042118303	3229	10285	100137049,81579,114882,11145,10162,5322	PLA2G4B,PLA2G12A,OSBPL8,PLAAT3,LPCAT3,PLA2G5
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.735033152592601	-0.307839675218361	22	6	0.00185816042118303	3229	10285	6464,3265,5578,5581,1839,3845	SHC1,HRAS,PRKCA,PRKCE,HBEGF,KRAS
R-HSA-177243	Interactions of Rev with host cellular proteins	0.737035366541031	-0.305119400778569	36	10	0.00309693403530505	3229	10285	5902,7514,57122,23636,11097,129401,9972,5901,10762,79023	RANBP1,XPO1,NUP107,NUP62,NUP42,NUP35,NUP153,RAN,NUP50,NUP37
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.739466057412879	-0.301826897258755	127	37	0.0114586559306287	3229	10285	2222,7296,11010,29079,1024,55090,6837,9440,51,1543,9439,9412,5468,90390,3157,1376,1387,400569,25942,23179,1581,9442,4800,5465,948,55588,4801,4520,9967,6667,84246,8841,51003,50486,23389,6604,2033	FDFT1,TXNRD1,GLIPR1,MED4,CDK8,MED9,MED22,MED17,ACOX1,CYP1A1,MED23,MED21,PPARG,MED30,HMGCS1,CPT2,CREBBP,MED11,SIN3A,RGL1,CYP7A1,MED27,NFYA,PPARA,CD36,MED29,NFYB,MTF1,THRAP3,SP1,MED10,HDAC3,MED31,G0S2,MED13L,SMARCD3,EP300
R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	0.742336959795669	-0.297952015183884	15	4	0.00123877361412202	3229	10285	27306,9536,5730,10728	HPGDS,PTGES,PTGDS,PTGES3
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	0.742336959795669	-0.297952015183884	15	4	0.00123877361412202	3229	10285	8823,8822,2246,8074	FGF16,FGF17,FGF1,FGF23
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.742336959795669	-0.297952015183884	15	4	0.00123877361412202	3229	10285	1645,1593,1646,1581	AKR1C1,CYP27A1,AKR1C2,CYP7A1
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	0.745351039668969	-0.293899977393163	67	19	0.00588417466707959	3229	10285	3014,8331,8348,354,55766,255626,8334,8345,8970,8342,367,3013,474382,94239,8350,23028,3015,85236,8335	H2AX,H2AC14,H2BC17,KLK3,H2AJ,H2BC1,H2AC6,H2BC9,H2BC11,H2BC14,AR,H2AC7,H2AB1,H2AZ2,H3C1,KDM1A,H2AZ1,H2BC12,H2AC4
R-HSA-8848021	Signaling by PTK6	0.745351039668969	-0.293899977393163	67	19	0.00588417466707959	3229	10285	200734,1027,63916,1019,9844,9021,1839,595,5770,7311,6233,161742,7314,207,867,3265,10457,27043,3845	SPRED2,CDKN1B,ELMO2,CDK4,ELMO1,SOCS3,HBEGF,CCND1,PTPN1,UBA52,RPS27A,SPRED1,UBB,AKT1,CBL,HRAS,GPNMB,PELP1,KRAS
R-HSA-1989781	PPARA activates gene expression	0.745673288938055	-0.29346772519188	124	36	0.0111489625270982	3229	10285	23179,1581,400569,6667,8841,84246,51003,50486,23389,6604,2033,4800,9442,5465,948,55588,4801,4520,9967,1024,55090,6837,51,9440,2222,7296,11010,29079,90390,3157,5468,1376,1387,1543,9439,9412	RGL1,CYP7A1,MED11,SP1,HDAC3,MED10,MED31,G0S2,MED13L,SMARCD3,EP300,NFYA,MED27,PPARA,CD36,MED29,NFYB,MTF1,THRAP3,CDK8,MED9,MED22,ACOX1,MED17,FDFT1,TXNRD1,GLIPR1,MED4,MED30,HMGCS1,PPARG,CPT2,CREBBP,CYP1A1,MED23,MED21
R-HSA-212300	PRC2 methylates histones and DNA	0.751202826209829	-0.286079588835005	74	21	0.0065035614741406	3229	10285	3015,8335,85236,3013,474382,5931,94239,8350,5928,2146,8345,8970,8342,5252,8348,8331,8726,3014,8334,55766,255626	H2AZ1,H2AC4,H2BC12,H2AC7,H2AB1,RBBP7,H2AZ2,H3C1,RBBP4,EZH2,H2BC9,H2BC11,H2BC14,PHF1,H2BC17,H2AC14,EED,H2AX,H2AC6,H2AJ,H2BC1
R-HSA-1474165	Reproduction	0.75444867086711	-0.281768033748318	26	7	0.00216785382471353	3229	10285	928,113177,2683,284359,5016,126123,8747	CD9,IZUMO4,B4GALT1,IZUMO1,OVGP1,IZUMO2,ADAM21
R-HSA-73848	Pyrimidine metabolism	0.75444867086711	-0.281768033748318	26	7	0.00216785382471353	3229	10285	1633,7371,7298,7372,1635,83549,51251	DCK,UCK2,TYMS,UMPS,DCTD,UCK1,NT5C3A
R-HSA-1187000	Fertilization	0.75444867086711	-0.281768033748318	26	7	0.00216785382471353	3229	10285	5016,284359,8747,126123,928,113177,2683	OVGP1,IZUMO1,ADAM21,IZUMO2,CD9,IZUMO4,B4GALT1
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.755174531758937	-0.28080638855566	40	11	0.00340662743883555	3229	10285	10574,26224,7157,6468,10576,22948,6950,10694,55135,8841,55294	CCT7,FBXL3,TP53,FBXW4,CCT2,CCT5,TCP1,CCT8,WRAP53,HDAC3,FBXW7
R-HSA-156584	Cytosolic sulfonation of small molecules	0.760465183474488	-0.273824949429411	19	5	0.00154846701765252	3229	10285	84836,27284,6818,9060,51000	ABHD14B,SULT1B1,SULT1A3,PAPSS2,SLC35B3
R-HSA-190861	Gap junction assembly	0.760465183474488	-0.273824949429411	19	5	0.00154846701765252	3229	10285	2706,10052,2705,84694,2697	GJB2,GJC1,GJB1,GJA10,GJA1
R-HSA-400253	Circadian Clock	0.760508552797824	-0.273767921063551	71	20	0.0061938680706101	3229	10285	1387,2033,6604,200186,8841,6500,1407,1385,1454,5465,26224,7314,5500,7311,5501,6233,2155,8553,4208,4783	CREBBP,EP300,SMARCD3,CRTC2,HDAC3,SKP1,CRY1,CREB1,CSNK1E,PPARA,FBXL3,UBB,PPP1CB,UBA52,PPP1CC,RPS27A,F7,BHLHE40,MEF2C,NFIL3
R-HSA-1592230	Mitochondrial biogenesis	0.761751672961484	-0.272134664910678	54	15	0.00464540105295757	3229	10285	56652,5465,1385,2553,200186,8841,506,5571,1387,5564,6604,4208,51106,2551,6742	TWNK,PPARA,CREB1,GABPB1,CRTC2,HDAC3,ATP5F1B,PRKAG1,CREBBP,PRKAB1,SMARCD3,MEF2C,TFB1M,GABPA,SSBP1
R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	7424,7422	VEGFC,VEGFA
R-HSA-110329	Cleavage of the damaged pyrimidine	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	4968,23583	OGG1,SMUG1
R-HSA-8850843	Phosphate bond hydrolysis by NTPDase proteins	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	9583,956	ENTPD4,ENTPD3
R-HSA-210747	Regulation of gene expression in early pancreatic precursor cells	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	6928,2255	HNF1B,FGF10
R-HSA-194313	VEGF ligand-receptor interactions	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	7424,7422	VEGFC,VEGFA
R-HSA-177128	Conjugation of salicylate with glycine	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	10249,389396	GLYAT,GLYATL3
R-HSA-73928	Depyrimidination	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	4968,23583	OGG1,SMUG1
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	7016,9459	TESK1,ARHGEF6
R-HSA-193634	Axonal growth inhibition (RHOA activation)	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	4974,57142	OMG,RTN4
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	6368,50865	CCL23,HEBP1
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	4968,23583	OGG1,SMUG1
R-HSA-2408508	Metabolism of ingested SeMet, Sec, MeSec into H2Se	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	3176,27232	HNMT,GNMT
R-HSA-977347	Serine biosynthesis	0.771382048357501	-0.259571504988387	8	2	0.00061938680706101	3229	10285	57515,10955	SERINC1,SERINC3
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.771606729491327	-0.259280276512018	30	8	0.00247754722824404	3229	10285	55851,7314,51107,23385,7311,6233,5664,1272	PSENEN,UBB,APH1A,NCSTN,UBA52,RPS27A,PSEN2,CNTN1
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.771606729491327	-0.259280276512018	30	8	0.00247754722824404	3229	10285	6464,9402,10768,7410,3702,6850,3937,5530	SHC1,GRAP2,AHCYL1,VAV2,ITK,SYK,LCP2,PPP3CA
R-HSA-373080	Class B/2 (Secretin family receptors)	0.77562255560433	-0.254089274545614	92	26	0.00805202849179312	3229	10285	10268,51764,5744,1393,2785,7476,2791,2787,7349,2790,1394,8323,2793,7480,2784,113091,7976,2782,7472,30817,2788,59345,79924,55970,54331,8322	RAMP3,GNG13,PTHLH,CRHBP,GNG3,WNT7A,GNG11,GNG5,UCN,GNG10,CRHR1,FZD6,GNGT2,WNT10B,GNB3,PTH2,FZD3,GNB1,WNT2,ADGRE2,GNG7,GNB4,ADM2,GNG12,GNG2,FZD4
R-HSA-3878781	Glycogen storage disease type IV (GBE1)	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	2997	GYS1
R-HSA-8849474	PTK6 Activates STAT3	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	9021	SOCS3
R-HSA-1855191	Synthesis of IPs in the nucleus	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	9807	IP6K1
R-HSA-6807062	Cholesterol biosynthesis via lathosterol	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	6309	SC5D
R-HSA-5083630	Defective LFNG causes SCDO3	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	4853	NOTCH2
R-HSA-209905	Catecholamine biosynthesis	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	1621	DBH
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	3611	ILK
R-HSA-1296053	Classical Kir channels	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	3759	KCNJ2
R-HSA-140179	Amine Oxidase reactions	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	196743	PAOX
R-HSA-6807047	Cholesterol biosynthesis via desmosterol	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	6309	SC5D
R-HSA-5619099	Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	553	AVPR1B
R-HSA-6783984	Glycine degradation	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	275	AMT
R-HSA-167060	NGF processing	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	5045	FURIN
R-HSA-194306	Neurophilin interactions with VEGF and VEGFR	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	8829	NRP1
R-HSA-176034	Interactions of Tat with host cellular proteins	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	1025	CDK9
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	5925	RB1
R-HSA-8848584	Wax biosynthesis	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	55711	FAR2
R-HSA-165158	Activation of AKT2	0.778537024801933	-0.250338729684285	4	1	0.000309693403530505	3229	10285	208	AKT2
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	159,5471,8833	ADSS2,PPAT,GMPS
R-HSA-211979	Eicosanoids	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	126410,66002,11283	CYP4F22,CYP4F12,CYP4F8
R-HSA-1475029	Reversible hydration of carbon dioxide	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	760,771,23632	CA2,CA12,CA14
R-HSA-211958	Miscellaneous substrates	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	1565,64816,126410	CYP2D6,CYP3A43,CYP4F22
R-HSA-71384	Ethanol oxidation	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	125,55902,124	ADH1B,ACSS2,ADH1A
R-HSA-209822	Glycoprotein hormones	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	3972,94115,3623	LHB,CGB8,INHA
R-HSA-1296346	Tandem pore domain potassium channels	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	89822,54207,56659	KCNK17,KCNK10,KCNK13
R-HSA-166786	Creation of C4 and C2 activators	0.779338831190916	-0.249309371078212	12	3	0.000929080210591514	3229	10285	714,2220,4153	C1QC,FCN2,MBL2
R-HSA-3214847	HATs acetylate histones	0.786222607973095	-0.240515310400325	143	41	0.0126974295447507	3229	10285	8464,8329,8348,10856,55929,1810,8342,8970,92815,27097,3013,9913,5931,10474,8350,86,60,221613,8607,117143,79960,1387,6944,6881,8331,55683,255626,112869,6880,56943,8334,55167,8345,54859,10933,55140,85236,8335,2033,64769,84289	SUPT3H,H2AC13,H2BC17,RUVBL2,DMAP1,DR1,H2BC14,H2BC11,H2AC25,TAF5L,H2AC7,SUPT7L,RBBP7,TADA3,H3C1,ACTL6A,ACTB,H2AC1,RUVBL1,TADA1,JADE1,CREBBP,VPS72,TAF10,H2AC14,KANSL3,H2BC1,SGF29,TAF9,ENY2,H2AC6,MSL2,H2BC9,ELP6,MORF4L1,ELP3,H2BC12,H2AC4,EP300,MEAF6,ING5
R-HSA-192105	Synthesis of bile acids and bile salts	0.786955826274146	-0.239583161397796	34	9	0.00278724063177454	3229	10285	9023,1645,1646,23600,10005,51302,1593,1581,5007	CH25H,AKR1C1,AKR1C2,AMACR,ACOT8,CYP39A1,CYP27A1,CYP7A1,OSBP
R-HSA-390522	Striated Muscle Contraction	0.786955826274146	-0.239583161397796	34	9	0.00278724063177454	3229	10285	7111,7170,8557,29767,7125,7139,1674,29766,7135	TMOD1,TPM3,TCAP,TMOD2,TNNC2,TNNT2,DES,TMOD3,TNNI1
R-HSA-1489509	DAG and IP3 signaling	0.786955826274146	-0.239583161397796	34	9	0.00278724063177454	3229	10285	5136,5567,5578,109,108,5581,10768,5153,1385	PDE1A,PRKACB,PRKCA,ADCY3,ADCY2,PRKCE,AHCYL1,PDE1B,CREB1
R-HSA-1221632	Meiotic synapsis	0.787585537237129	-0.238783295467119	79	22	0.00681325487767111	3229	10285	8335,85236,672,7329,4001,8345,4000,5885,8334,255626,8331,644186,3015,474382,94239,56158,3013,8970,8342,55766,8348,3014	H2AC4,H2BC12,BRCA1,UBE2I,LMNB1,H2BC9,LMNA,RAD21,H2AC6,H2BC1,H2AC14,SYCE3,H2AZ1,H2AB1,H2AZ2,TEX12,H2AC7,H2BC11,H2BC14,H2AJ,H2BC17,H2AX
R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	0.790411551697823	-0.23520151765297	16	4	0.00123877361412202	3229	10285	5277,5279,284098,8818	PIGA,PIGC,PIGW,DPM2
R-HSA-159418	Recycling of bile acids and salts	0.790411551697823	-0.23520151765297	16	4	0.00123877361412202	3229	10285	80765,213,6579,28234	STARD5,ALB,SLCO1A2,SLCO1B3
R-HSA-1963642	PI3K events in ERBB2 signaling	0.790411551697823	-0.23520151765297	16	4	0.00123877361412202	3229	10285	2549,5295,1839,5290	GAB1,PIK3R1,HBEGF,PIK3CA
R-HSA-549132	Organic cation/anion/zwitterion transport	0.790411551697823	-0.23520151765297	16	4	0.00123877361412202	3229	10285	116085,9376,9356,861	SLC22A12,SLC22A8,SLC22A6,RUNX1
R-HSA-399956	CRMPs in Sema3A signaling	0.790411551697823	-0.23520151765297	16	4	0.00123877361412202	3229	10285	1400,1020,8851,8829	CRMP1,CDK5,CDK5R1,NRP1
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.790411551697823	-0.23520151765297	16	4	0.00123877361412202	3229	10285	5908,7450,6714,5906	RAP1B,VWF,SRC,RAP1A
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.790411551697823	-0.23520151765297	16	4	0.00123877361412202	3229	10285	6714,5906,5908,7450	SRC,RAP1A,RAP1B,VWF
R-HSA-180024	DARPP-32 events	0.791397116160726	-0.233955394009242	27	7	0.00216785382471353	3229	10285	5516,1020,5567,5142,5530,84152,5518	PPP2CB,CDK5,PRKACB,PDE4B,PPP3CA,PPP1R1B,PPP2R1A
R-HSA-427359	SIRT1 negatively regulates rRNA Expression	0.793241713712388	-0.231627294571011	69	19	0.00588417466707959	3229	10285	3015,100302240,85236,8335,3013,8350,94239,6839,474382,8345,8342,8970,8331,8348,3014,79101,8334,255626,55766	H2AZ1,MIR1304,H2BC12,H2AC4,H2AC7,H3C1,H2AZ2,SUV39H1,H2AB1,H2BC9,H2BC14,H2BC11,H2AC14,H2BC17,H2AX,TAF1D,H2AC6,H2BC1,H2AJ
R-HSA-2142753	Arachidonic acid metabolism	0.801067553189523	-0.221809999403044	59	16	0.00495509445648808	3229	10285	5730,2876,1800,11283,1545,1558,10728,2877,1543,126410,9536,64180,2879,241,27306,1559	PTGDS,GPX1,DPEP1,CYP4F8,CYP1B1,CYP2C8,PTGES3,GPX2,CYP1A1,CYP4F22,PTGES,DPEP3,GPX4,ALOX5AP,HPGDS,CYP2C9
R-HSA-194223	HDL-mediated lipid transport	0.801982752621905	-0.220668176805839	20	5	0.00154846701765252	3229	10285	213,29801,344,649,5567	ALB,ZDHHC8,APOC2,BMP1,PRKACB
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	0.804726740403623	-0.21725251210551	31	8	0.00247754722824404	3229	10285	443,57515,29920,4942,2875,2752,5831,10955	ASPA,SERINC1,PYCR2,OAT,GPT,GLUL,PYCR1,SERINC3
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.804726740403623	-0.21725251210551	31	8	0.00247754722824404	3229	10285	3836,10762,79023,57122,11097,23636,129401,9972	KPNA1,NUP50,NUP37,NUP107,NUP42,NUP62,NUP35,NUP153
R-HSA-8875878	MET promotes cell motility	0.804726740403623	-0.21725251210551	31	8	0.00247754722824404	3229	10285	4233,2549,5908,1399,6714,3913,3673,5906	MET,GAB1,RAP1B,CRKL,SRC,LAMB2,ITGA2,RAP1A
R-HSA-193704	p75 NTR receptor-mediated signalling	0.806654236678944	-0.214860157693925	97	27	0.00836172189532363	3229	10285	6655,4974,55851,7410,4790,11108,26574,51107,6610,84904,5664,7189,57142,3551,27018,7074,4792,23385,4615,8841,9459,572,221472,7314,8878,7311,6233	SOS2,OMG,PSENEN,VAV2,NFKB1,PRDM4,AATF,APH1A,SMPD2,ARHGEF39,PSEN2,TRAF6,RTN4,IKBKB,BEX3,TIAM1,NFKBIA,NCSTN,MYD88,HDAC3,ARHGEF6,BAD,FGD2,UBB,SQSTM1,UBA52,RPS27A
R-HSA-156588	Glucuronidation	0.813260287243829	-0.206704064162011	24	6	0.00185816042118303	3229	10285	79799,54658,7360,7358,23169,55347	UGT2A3,UGT1A1,UGP2,UGDH,SLC35D1,ABHD10
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.813260287243829	-0.206704064162011	24	6	0.00185816042118303	3229	10285	1593,1581,1645,1646,10005,23600	CYP27A1,CYP7A1,AKR1C1,AKR1C2,ACOT8,AMACR
R-HSA-1461957	Beta defensins	0.813409190623075	-0.206520986552591	42	11	0.00340662743883555	3229	10285	1672,245937,729230,245930,245934,1235,7097,140881,245929,245928,7096	DEFB1,DEFB124,CCR2,DEFB116,DEFB121,CCR6,TLR2,DEFB129,DEFB115,DEFB114,TLR1
R-HSA-3214815	HDACs deacetylate histones	0.814039802095173	-0.205746017252196	94	26	0.00805202849179312	3229	10285	25855,5928,8342,92815,8970,10284,8329,8348,221613,57504,23028,3013,8819,79685,8350,5931,8345,53615,8331,255626,8334,8841,51317,85236,8335,9219	BRMS1,RBBP4,H2BC14,H2AC25,H2BC11,SAP18,H2AC13,H2BC17,H2AC1,MTA3,KDM1A,H2AC7,SAP30,SAP30L,H3C1,RBBP7,H2BC9,MBD3,H2AC14,H2BC1,H2AC6,HDAC3,PHF21A,H2BC12,H2AC4,MTA2
R-HSA-2187338	Visual phototransduction	0.817153677304165	-0.201928102295129	101	28	0.00867141529885413	3229	10285	5948,5957,23173,6385,338328,29967,9227,285440,6383,10988,5588,3949,2782,5578,2342,1645,2817,51109,344,145226,2239,7276,9249,157506,3292,5145,26020,8630	RBP2,RCVRN,METAP1,SDC4,GPIHBP1,LRP12,LRAT,CYP4V2,SDC2,METAP2,PRKCQ,LDLR,GNB1,PRKCA,FNTB,AKR1C1,GPC1,RDH11,APOC2,RDH12,GPC4,TTR,DHRS3,RDH10,HSD17B1,PDE6A,LRP10,HSD17B6
R-HSA-977225	Amyloid fiber formation	0.817153677304165	-0.201928102295129	101	28	0.00867141529885413	3229	10285	54959,85236,8335,1471,4069,6233,8345,7311,7314,8331,8334,6478,255626,3015,7276,3013,9445,474382,8350,5045,8970,8342,8348,6477,23621,5617,3014,567	ODAM,H2BC12,H2AC4,CST3,LYZ,RPS27A,H2BC9,UBA52,UBB,H2AC14,H2AC6,SIAH2,H2BC1,H2AZ1,TTR,H2AC7,ITM2B,H2AB1,H3C1,FURIN,H2BC11,H2BC14,H2BC17,SIAH1,BACE1,PRL,H2AX,B2M
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.821553393707685	-0.196558348233253	91	25	0.00774233508826262	3229	10285	474382,94239,8350,3013,1387,3015,8607,4609,7088,55766,8348,3014,79577,8970,8342,2033,85236,8335,8334,255626,7015,1499,8331,607,8345	H2AB1,H2AZ2,H3C1,H2AC7,CREBBP,H2AZ1,RUVBL1,MYC,TLE1,H2AJ,H2BC17,H2AX,CDC73,H2BC11,H2BC14,EP300,H2BC12,H2AC4,H2AC6,H2BC1,TERT,CTNNB1,H2AC14,BCL9,H2BC9
R-HSA-4839726	Chromatin organization	0.822925086522302	-0.194890107329855	279	81	0.0250851656859709	3229	10285	2033,85236,6604,64754,51317,595,6598,11240,6187,55170,112869,6605,6881,6944,1019,221613,60,23028,51412,8819,86,8350,5931,9913,3717,92815,8970,8342,55929,10856,84864,4790,8348,84193,8335,84289,9219,64769,8841,51111,10933,55140,53615,54859,8345,55167,22992,2146,6880,255626,56943,8334,55683,8331,80854,79960,1387,117143,57504,3015,8607,79685,474382,6839,10474,94239,3013,10284,27097,84661,5928,25855,1810,23030,55766,79084,10419,8726,3014,8464,8329	EP300,H2BC12,SMARCD3,SMYD3,PHF21A,CCND1,SMARCB1,PADI2,RPS2,PRMT6,SGF29,SMARCE1,TAF10,VPS72,CDK4,H2AC1,ACTB,KDM1A,ACTL6B,SAP30,ACTL6A,H3C1,RBBP7,SUPT7L,JAK2,H2AC25,H2BC11,H2BC14,DMAP1,RUVBL2,RIOX2,NFKB1,H2BC17,SETD3,H2AC4,ING5,MTA2,MEAF6,HDAC3,KMT5B,MORF4L1,ELP3,MBD3,ELP6,H2BC9,MSL2,KDM2A,EZH2,TAF9,H2BC1,ENY2,H2AC6,KANSL3,H2AC14,SETD7,JADE1,CREBBP,TADA1,MTA3,H2AZ1,RUVBL1,SAP30L,H2AB1,SUV39H1,TADA3,H2AZ2,H2AC7,SAP18,TAF5L,DPY30,RBBP4,BRMS1,DR1,KDM4B,H2AJ,WDR77,PRMT5,EED,H2AX,SUPT3H,H2AC13
R-HSA-3247509	Chromatin modifying enzymes	0.822925086522302	-0.194890107329855	279	81	0.0250851656859709	3229	10285	8841,8335,84289,64769,9219,10933,55140,51111,55167,54859,8345,2146,22992,53615,80854,55683,8331,255626,6880,56943,8334,57504,8607,3015,117143,79960,1387,3013,79685,10474,94239,6839,474382,84661,25855,1810,5928,10284,27097,3014,8464,8329,8726,79084,10419,55766,23030,64754,51317,6604,85236,2033,595,6598,11240,6881,55170,112869,6187,6605,221613,60,51412,23028,1019,6944,9913,3717,8819,8350,5931,86,55929,8342,92815,8970,4790,84193,8348,84864,10856	HDAC3,H2AC4,ING5,MEAF6,MTA2,MORF4L1,ELP3,KMT5B,MSL2,ELP6,H2BC9,EZH2,KDM2A,MBD3,SETD7,KANSL3,H2AC14,H2BC1,TAF9,ENY2,H2AC6,MTA3,RUVBL1,H2AZ1,TADA1,JADE1,CREBBP,H2AC7,SAP30L,TADA3,H2AZ2,SUV39H1,H2AB1,DPY30,BRMS1,DR1,RBBP4,SAP18,TAF5L,H2AX,SUPT3H,H2AC13,EED,WDR77,PRMT5,H2AJ,KDM4B,SMYD3,PHF21A,SMARCD3,H2BC12,EP300,CCND1,SMARCB1,PADI2,TAF10,PRMT6,SGF29,RPS2,SMARCE1,H2AC1,ACTB,ACTL6B,KDM1A,CDK4,VPS72,SUPT7L,JAK2,SAP30,H3C1,RBBP7,ACTL6A,DMAP1,H2BC14,H2AC25,H2BC11,NFKB1,SETD3,H2BC17,RIOX2,RUVBL2
R-HSA-111933	Calmodulin induced events	0.823981069462057	-0.193607723290385	28	7	0.00216785382471353	3229	10285	108,109,5578,5567,5136,1385,5153	ADCY2,ADCY3,PRKCA,PRKACB,PDE1A,CREB1,PDE1B
R-HSA-111997	CaM pathway	0.823981069462057	-0.193607723290385	28	7	0.00216785382471353	3229	10285	1385,5153,5567,109,5578,108,5136	CREB1,PDE1B,PRKACB,ADCY3,PRKCA,ADCY2,PDE1A
R-HSA-1660662	Glycosphingolipid metabolism	0.824925936981973	-0.192461670032509	46	12	0.00371632084236606	3229	10285	51228,7357,3073,5476,64781,80772,23344,6610,4758,8706,3074,2581	GLTP,UGCG,HEXA,CTSA,CERK,CPTP,ESYT1,SMPD2,NEU1,B3GALNT1,HEXB,GALC
R-HSA-70153	Glucose transport	0.824925936981973	-0.192461670032509	46	12	0.00371632084236606	3229	10285	85414,57122,11097,129401,6513,10762,2542,79023,92579,6515,23636,9972	SLC45A3,NUP107,NUP42,NUP35,SLC2A1,NUP50,SLC37A4,NUP37,G6PC3,SLC2A3,NUP62,NUP153
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	1175,1173,160	AP2S1,AP2M1,AP2A1
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	5460,6657,27022	POU5F1,SOX2,FOXD3
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	9391,64428,10101	CIAO1,CIAO3,NUBP2
R-HSA-75205	Dissolution of Fibrin Clot	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	5269,6281,5340	SERPINB6,S100A10,PLG
R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	784,785,783	CACNB3,CACNB4,CACNB2
R-HSA-350054	Notch-HLH transcription pathway	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	1387,4853,3516	CREBBP,NOTCH2,RBPJ
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	2620,6709,118	GAS2,SPTAN1,ADD1
R-HSA-74217	Purine salvage	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	4860,132,1633	PNP,ADK,DCK
R-HSA-8866907	Activation of the TFAP2 (AP-2) family of transcription factors	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	4435,1387,2033	CITED1,CREBBP,EP300
R-HSA-5626467	RHO GTPases activate IQGAPs	0.826523219519364	-0.190527268323348	13	3	0.000929080210591514	3229	10285	998,1499,1495	CDC42,CTNNB1,CTNNA1
R-HSA-159424	Conjugation of carboxylic acids	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	389396,10249	GLYATL3,GLYAT
R-HSA-2214320	Anchoring fibril formation	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	100313843,649	MIR711,BMP1
R-HSA-428890	Role of Abl in Robo-Slit signaling	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	2817,10486	GPC1,CAP2
R-HSA-156587	Amino Acid conjugation	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	10249,389396	GLYAT,GLYATL3
R-HSA-193697	p75NTR regulates axonogenesis	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	57142,4974	RTN4,OMG
R-HSA-8854691	Interleukin-19, 20, 22, 24	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	53833,50616	IL20RB,IL22
R-HSA-428543	Inactivation of Cdc42 and Rac	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	2817,998	GPC1,CDC42
R-HSA-74182	Ketone body metabolism	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	38,5019	ACAT1,OXCT1
R-HSA-163765	ChREBP activates metabolic gene expression	0.827796518527538	-0.188987905369103	9	2	0.00061938680706101	3229	10285	10554,31	AGPAT1,ACACA
R-HSA-912446	Meiotic recombination	0.829195480387829	-0.187299349004797	88	24	0.00743264168473212	3229	10285	55766,3014,8348,6118,8342,8970,27030,94239,8350,474382,3013,1019,3015,255626,8334,84057,8331,5932,8345,6119,85236,8335,4683,672	H2AJ,H2AX,H2BC17,RPA2,H2BC14,H2BC11,MLH3,H2AZ2,H3C1,H2AB1,H2AC7,CDK4,H2AZ1,H2BC1,H2AC6,MND1,H2AC14,RBBP8,H2BC9,RPA3,H2BC12,H2AC4,NBN,BRCA1
R-HSA-156711	Polo-like kinase mediated events	0.830998222619873	-0.185127622973894	17	4	0.00123877361412202	3229	10285	2033,4605,891,5928	EP300,MYBL2,CCNB1,RBBP4
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	0.830998222619873	-0.185127622973894	17	4	0.00123877361412202	3229	10285	1385,1742,4747,818	CREB1,DLG4,NEFL,CAMK2G
R-HSA-111931	PKA-mediated phosphorylation of CREB	0.830998222619873	-0.185127622973894	17	4	0.00123877361412202	3229	10285	1385,109,5567,108	CREB1,ADCY3,PRKACB,ADCY2
R-HSA-70171	Glycolysis	0.834068640049779	-0.181439577792072	32	8	0.00247754722824404	3229	10285	2026,5223,5518,5516,2597,5208,5230,2023	ENO2,PGAM1,PPP2R1A,PPP2CB,GAPDH,PFKFB2,PGK1,ENO1
R-HSA-376176	Signaling by Robo receptor	0.834068640049779	-0.181439577792072	32	8	0.00247754722824404	3229	10285	4690,57144,998,56924,2817,5062,10486,6655	NCK1,PAK5,CDC42,PAK6,GPC1,PAK2,CAP2,SOS2
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.835527608276838	-0.179691887474871	78	21	0.0065035614741406	3229	10285	9972,672,7329,23636,7703,6613,1911,1069,5371,79023,6612,10762,8554,9656,6015,129401,11097,57122,7341,5885,56160	NUP153,BRCA1,UBE2I,NUP62,PCGF2,SUMO2,PHC1,CETN2,PML,NUP37,SUMO3,NUP50,PIAS1,MDC1,RING1,NUP35,NUP42,NUP107,SUMO1,RAD21,NSMCE3
R-HSA-2028269	Signaling by Hippo	0.837580074161699	-0.177238408914008	21	5	0.00154846701765252	3229	10285	1856,6789,7529,6788,60485	DVL2,STK4,YWHAB,STK3,SAV1
R-HSA-210745	Regulation of gene expression in beta cells	0.837580074161699	-0.177238408914008	21	5	0.00154846701765252	3229	10285	208,3171,5080,207,10000	AKT2,FOXA3,PAX6,AKT1,AKT3
R-HSA-212718	EGFR interacts with phospholipase C-gamma	0.843519364093021	-0.170172420421419	36	9	0.00278724063177454	3229	10285	5581,10768,5153,1385,5136,109,5578,5567,108	PRKCE,AHCYL1,PDE1B,CREB1,PDE1A,ADCY3,PRKCA,PRKACB,ADCY2
R-HSA-167021	PLC-gamma1 signalling	0.843519364093021	-0.170172420421419	36	9	0.00278724063177454	3229	10285	5567,109,5578,108,5136,1385,10768,5153,5581	PRKACB,ADCY3,PRKCA,ADCY2,PDE1A,CREB1,AHCYL1,PDE1B,PRKCE
R-HSA-8849473	PTK6 Expression	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	27043	PELP1
R-HSA-2855086	Ficolins bind to repetitive carbohydrate structures on the target cell surface	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	2220	FCN2
R-HSA-8866423	VLDL biosynthesis	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	346	APOC4
R-HSA-74713	IRS activation	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	2887	GRB10
R-HSA-8852405	Signaling by MST1	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	10653	SPINT2
R-HSA-1483226	Synthesis of PI	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	10423	CDIPT
R-HSA-157881	Cyclin B2 mediated events	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	983	CDK1
R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	284111	SLC13A5
R-HSA-3000471	Scavenging by Class B Receptors	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	948	CD36
R-HSA-8866376	Reelin signalling pathway	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	7436	VLDLR
R-HSA-71262	Carnitine synthesis	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	6470	SHMT1
R-HSA-8853383	Lysosomal oligosaccharide catabolism	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	693216	MIR631
R-HSA-391906	Leukotriene receptors	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	2840	GPR17
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	1385	CREB1
R-HSA-68911	G2 Phase	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	890	CCNA2
R-HSA-8875513	MET interacts with TNS proteins	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	4233	MET
R-HSA-6785470	tRNA processing in the mitochondrion	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	3028	HSD17B10
R-HSA-163358	PKA-mediated phosphorylation of key metabolic factors	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	5567	PRKACB
R-HSA-187024	NGF-independant TRKA activation	0.848092899413071	-0.164765097995869	5	1	0.000309693403530505	3229	10285	4915	NTRK2
R-HSA-2132295	MHC class II antigen presentation	0.84926985962005	-0.163378287322255	103	28	0.00867141529885413	3229	10285	1513,10671,10484,10121,8655,64837,6396,1508,8905,8907,375,5476,1781,9371,1509,1780,51128,3796,1175,10120,11258,29127,1785,1075,3797,51164,1173,160	CTSK,DCTN6,SEC23A,ACTR1A,DYNLL1,KLC2,SEC13,CTSB,AP1S2,AP1M1,ARF1,CTSA,DYNC1I2,KIF3B,CTSD,DYNC1I1,SAR1B,KIF2A,AP2S1,ACTR1B,DCTN3,RACGAP1,DNM2,CTSC,KIF3C,DCTN4,AP2M1,AP2A1
R-HSA-186712	Regulation of beta-cell development	0.859827468229441	-0.151023528198993	33	8	0.00247754722824404	3229	10285	208,5080,6928,3171,2255,10000,207,3516	AKT2,PAX6,HNF1B,FOXA3,FGF10,AKT3,AKT1,RBPJ
R-HSA-202433	Generation of second messenger molecules	0.859827468229441	-0.151023528198993	33	8	0.00247754722824404	3229	10285	3702,4690,3937,919,5062,917,9402,920	ITK,NCK1,LCP2,CD247,PAK2,CD3G,GRAP2,CD4
R-HSA-1222556	ROS, RNS production in phagocytes	0.859827468229441	-0.151023528198993	33	8	0.00247754722824404	3229	10285	8992,533,528,51382,9550,90423,534,523	ATP6V0E1,ATP6V0B,ATP6V1C1,ATP6V1D,ATP6V1G1,ATP6V1E2,ATP6V1G2,ATP6V1A
R-HSA-180746	Nuclear import of Rev protein	0.859827468229441	-0.151023528198993	33	8	0.00247754722824404	3229	10285	129401,23636,11097,9972,57122,79023,10762,5901	NUP35,NUP62,NUP42,NUP153,NUP107,NUP37,NUP50,RAN
R-HSA-418359	Reduction of cytosolic Ca++ levels	0.864773676196133	-0.14528745230158	14	3	0.000929080210591514	3229	10285	6717,6546,493	SRI,SLC8A1,ATP2B4
R-HSA-209952	Peptide hormone biosynthesis	0.864773676196133	-0.14528745230158	14	3	0.000929080210591514	3229	10285	3972,94115,3623	LHB,CGB8,INHA
R-HSA-428790	Facilitative Na+-independent glucose transporters	0.864773676196133	-0.14528745230158	14	3	0.000929080210591514	3229	10285	6513,29988,6515	SLC2A1,SLC2A8,SLC2A3
R-HSA-1483213	Synthesis of PE	0.864773676196133	-0.14528745230158	14	3	0.000929080210591514	3229	10285	85465,55224,1120	SELENOI,ETNK2,CHKB
R-HSA-69205	G1/S-Specific Transcription	0.864802849317138	-0.145253717892518	18	4	0.00123877361412202	3229	10285	983,7029,7298,5111	CDK1,TFDP2,TYMS,PCNA
R-HSA-372790	Signaling by GPCR	0.866231223765027	-0.143603404020265	1299	391	0.121090120780427	3229	10285	8074,56477,119692,5136,1814,5529,2797,391,5525,6352,5030,5588,5908,10235,5997,7311,10850,113091,84292,2782,138802,125958,2831,7074,2255,79544,388,1235,28956,390157,10000,5687,10268,1233,119765,140,3560,2925,283162,4886,5734,81696,5702,2861,161742,80834,2912,11255,1128,5021,5692,3972,114814,7932,7979,5705,5699,64108,5737,2859,1020,259285,387129,4829,219431,81285,5709,10287,125963,219986,5695,5693,5684,2919,109,441639,1232,122042,219865,3576,1131,5567,283694,1524,5713,54331,553,7476,5906,2785,84904,390437,2252,2771,120787,84152,59345,54429,9459,5138,79924,9283,219983,64805,390648,9861,1839,5880,6001,442361,51764,6709,2246,5604,5032,442191,5151,2147,5894,2767,2550,26339,6750,155,5716,8490,6093,9630,3265,5516,2791,8682,5690,8649,7432,390162,5700,2837,5245,5710,4988,3562,5173,6464,4852,4283,1268,122706,6364,4986,5294,84432,1393,283869,154,3717,341418,259292,124538,1230,2788,219959,7472,10563,390433,7314,221472,5518,5720,338675,7433,55970,1236,208,8862,9170,4889,219960,27198,401666,403253,6346,5718,390436,390199,5731,2918,2840,51738,148,7976,134,57007,2248,10888,5698,2790,5686,10798,23236,5691,5037,121130,3356,1902,7480,120586,2911,4887,998,7529,390431,441608,219858,6714,9475,1852,390261,6373,10817,134864,1133,390093,6375,2775,3815,3567,2773,134083,818,151306,3350,6655,8823,2781,26533,8323,7450,2796,5150,4295,5996,5368,219437,6233,170589,1843,3558,84539,6869,680,1742,8315,5330,1445,5295,121364,6363,1385,10911,392138,6863,1394,2833,3060,26211,5578,8477,8322,5536,26686,341152,8822,441670,2921,5744,8503,1132,26692,9628,390059,259286,219954,1909,3577,26493,5530,4747,11221,5721,3274,200734,4233,153,2787,152559,221035,5296,3561,1848,50837,6366,10161,3845,5539,27006,50838,54886,729230,50865,27334,207,5290,5707,390195,8452,1234,5682,30817,219981,441669,283297,442186,406974,25780,11245,3361,80346,6387,2260,5685,5028,3355,5694,390260,5683,79290,108,57406,219875,5689,10768,256933,5704,7852,219870,187,7410,390265,5732,10213,390152,284,5153,6711,6019,6376,117579,120775,26534,7349,2838,2776,10663,53358,4987,5579,2793,2784,5581,1437,8698,7253,92840,26648,119772,50833,3716,6370,4296,6870,1812,2847,390429,319100,6368,26090,4992,3627,5142,3559	FGF23,CCL28,OR51S1,PDE1A,DRD3,PPP2R5E,GNRH2,RHOG,PPP2R5A,CCL5,P2RY4,PRKCQ,RAP1B,RASGRP2,RGS2,UBA52,CCL27,PTH2,WDR83,GNB1,OR13C8,OR7D4,NPBWR1,TIAM1,FGF10,OR4K1,RHOB,CCR6,LAMTOR2,OR8K1,AKT3,PSMA6,RAMP3,CCR4,OR4B1,ADORA3,IL2RB,GRPR,OR8B4,NPY1R,PTGER4,OR5V1,PSMC3,GPR37,SPRED1,TAS1R2,GRM2,HRH3,CHRM1,OXTR,PSMB4,LHB,GNRHR2,OR2H2,SEM1,PSMC5,PSMB10,RTP4,PTGFR,GPR35,CDK5,TAS2R39,NPSR1,NMBR,OR4S2,OR51E2,PSMD3,RGS19,OR1M1,OR4D11,PSMB7,PSMB5,PSMA3,CXCL1,ADCY3,OR9K2,CCR3,RXFP2,OR8G5,CXCL8,CHRM3,PRKACB,OR4N4,CX3CR1,PSMD7,GNG2,AVPR1B,WNT7A,RAP1A,GNG3,ARHGEF39,OR4N5,FGF7,GNAI2,OR52W1,PPP1R1B,GNB4,TAS2R5,ARHGEF6,PDE2A,ADM2,GPR37L1,OR4D6,P2RY12,OR4F6,PSMD6,HBEGF,RAC2,RGS10,OR2A2,GNG13,SPTAN1,FGF1,MAP2K1,P2RY11,OR14J1,PDE8A,F2,RAF1,GNA11,GABBR1,OR5K1,SST,ADRB3,PSMD10,RGS5,ROCK1,GNA14,HRAS,PPP2CB,GNG11,PEA15,PSMB2,LAMTOR3,VIP,OR5M9,PSMC1,UTS2R,PHB1,PSMD4,OPRM1,IL3,PDYN,SHC1,NPY,CXCL9,CNR1,PSMB11,CCL20,OPRK1,PIK3CG,PROK1,CRHBP,NPW,ADRB2,JAK2,OR6C4,TAS2R46,OR4D2,CCR1,GNG7,OR1S1,WNT2,CXCL13,OR4K13,UBB,FGD2,PPP2R1A,PSME1,OR5AP2,VIPR1,GNG12,CCR7,AKT2,APLN,LPAR2,NPY5R,OR10Q1,HCAR1,OR51A4,OR4A47,CCL1,PSMD12,OR4K17,OR4D9,PTGER1,GRM8,GPR17,GHRL,ADRA1A,FZD3,ADORA1,ACKR3,FGF3,GPR83,PSMB9,GNG10,PSMA5,OR5I1,PLCB1,PSMB3,PEBP1,OR10P1,HTR2A,LPAR1,WNT10B,OR8I2,GRM1,NPY2R,CDC42,YWHAB,OR4K2,OR5B3,OR8B12,SRC,ROCK2,DUSP9,OR6M1,CXCL11,FRS3,TAAR1,CHRM5,OR10A6,XCL1,GNAO1,KIT,IL5,GNAI3,OR2Y1,CAMK2G,GPBAR1,HTR1A,SOS2,FGF16,GNAZ,OR10G3,FZD6,VWF,GNRH1,PDE7A,MLN,RGS1,PNOC,OR5L1,RPS27A,GPHA2,DUSP1,IL2,MCHR2,TACR1,BRS3,DLG4,BRAP,PLCB2,CSK,PIK3R1,OR10A7,CCL19,CREB1,UTS2,OR2A25,TAC1,CRHR1,CXCR3,HCRT,OR2F1,PRKCA,GPR65,FZD4,PPP5C,OR4E2,OR2AT4,FGF17,OR4M1,CXCL3,PTHLH,PIK3R3,CHRM4,OR2W1,RGS6,OR51M1,TAS2R40,OR9I1,EDNRA,CXCR1,OR8B8,PPP3CA,NEFL,DUSP10,PSME2,HRH2,SPRED2,MET,ADRB1,GNG5,PAQR3,REEP3,PIK3R2,IL2RG,DUSP6,TAS2R7,CCL21,LPAR6,KRAS,PPY,FGF22,TAS2R13,PLPPR1,CCR2,HEBP1,P2RY10,AKT1,PIK3CA,PSMD1,OR5AN1,CUL3,CCR5,PSMA1,ADGRE2,OR5A2,OR4Q3,OR10A4,OR2J3,MIR197,RASGRP3,GPR176,HTR5A,REEP4,CXCL12,FGFR1,PSMA4,P2RY1,HTR1F,PSMB6,OR6X1,PSMA2,OR13A1,ADCY2,ABHD6,OR4D5,PSMB1,AHCYL1,NPB,PSMC4,CXCR4,OR10G9,APLNR,VAV2,OR10G7,PTGER2,PSMD14,OR8H3,ANGPT1,PDE1B,SPTBN1,RLN2,CX3CL1,RLN3,OR2D3,OR10G2,UCN,GPR15,GNAQ,CXCR6,SHC3,OPRL1,PRKCB,GNGT2,GNB3,PRKCE,CSF2,S1PR4,TSHR,REEP6,OR7E24,OR52M1,TAS2R16,JAK1,CCL25,MAP3K11,TACR3,DRD1,MCHR1,OR4N2,TAAR6,CCL23,ABHD12,OR1F1,CXCL10,PDE4B,IL2RA
R-HSA-5576891	Cardiac conduction	0.866539207303905	-0.1432479229518	142	39	0.0120780427376897	3229	10285	1193,784,818,30818,10768,2258,481,7220,56659,3751,478,783,3759,4880,477,53826,2257,4882,3767,1760,29098,785,493,3752,54207,80228,5350,6324,6546,55800,30819,6717,10368,483,6786,89822,476,6327,2281	CLIC2,CACNB3,CAMK2G,KCNIP3,AHCYL1,FGF13,ATP1B1,TRPC1,KCNK13,KCND2,ATP1A3,CACNB2,KCNJ2,NPPC,ATP1A2,FXYD6,FGF12,NPR2,KCNJ11,DMPK,RANGRF,CACNB4,ATP2B4,KCND3,KCNK10,ORAI2,PLN,SCN1B,SLC8A1,SCN3B,KCNIP2,SRI,CACNG3,ATP1B3,STIM1,KCNK17,ATP1A1,SCN2B,FKBP1B
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	0.867740933438006	-0.141862072652065	22	5	0.00154846701765252	3229	10285	919,1445,920,917,26191	CD247,CSK,CD4,CD3G,PTPN22
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.867740933438006	-0.141862072652065	22	5	0.00154846701765252	3229	10285	241,1800,11283,126410,64180	ALOX5AP,DPEP1,CYP4F8,CYP4F22,DPEP3
R-HSA-70635	Urea cycle	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	57407,384	NMRAL1,ARG2
R-HSA-139915	Activation of PUMA and translocation to mitochondria	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	7029,7157	TFDP2,TP53
R-HSA-170660	Adenylate cyclase activating pathway	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	109,108	ADCY3,ADCY2
R-HSA-425381	Bicarbonate transporters	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	9498,57282	SLC4A8,SLC4A10
R-HSA-419812	Calcitonin-like ligand receptors	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	10268,79924	RAMP3,ADM2
R-HSA-74749	Signal attenuation	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	6464,2887	SHC1,GRB10
R-HSA-2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	5571,5564	PRKAG1,PRKAB1
R-HSA-428643	Organic anion transporters	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	26503,1468	SLC17A5,SLC25A10
R-HSA-418890	Role of second messengers in netrin-1 signaling	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	7220,5306	TRPC1,PITPNA
R-HSA-418886	Netrin mediated repulsion signals	0.871332310687019	-0.137731847123594	10	2	0.00061938680706101	3229	10285	6714,5781	SRC,PTPN11
R-HSA-379716	Cytosolic tRNA aminoacylation	0.872057761896651	-0.136899616559808	26	6	0.00185816042118303	3229	10285	4141,2193,3735,5917,9521,833	MARS1,FARSA,KARS1,RARS1,EEF1E1,CARS1
R-HSA-3238698	WNT ligand biogenesis and trafficking	0.872057761896651	-0.136899616559808	26	6	0.00185816042118303	3229	10285	7476,7472,9559,7480,50999,8724	WNT7A,WNT2,VPS26A,WNT10B,TMED5,SNX3
R-HSA-73923	Lipid digestion, mobilization, and transport	0.872131785621555	-0.136814736192242	115	31	0.00960049550944565	3229	10285	5567,5501,51099,10577,161247,5500,646486,3949,857,2167,29881,338328,3988,128486,7436,7376,213,255738,1173,160,29801,1175,2173,51128,29923,649,2171,29116,344,346,5045	PRKACB,PPP1CC,ABHD5,NPC2,FITM1,PPP1CB,FABP12,LDLR,CAV1,FABP4,NPC1L1,GPIHBP1,LIPA,FITM2,VLDLR,NR1H2,ALB,PCSK9,AP2M1,AP2A1,ZDHHC8,AP2S1,FABP7,SAR1B,HILPDA,BMP1,FABP5,MYLIP,APOC2,APOC4,FURIN
R-HSA-5620924	Intraflagellar transport	0.873858523171251	-0.13483678923119	41	10	0.00309693403530505	3229	10285	26160,51098,83657,64792,51668,8655,57728,55081,9371,3797	IFT172,IFT52,DYNLRB2,IFT22,IFT25,DYNLL1,WDR19,IFT57,KIF3B,KIF3C
R-HSA-442755	Activation of NMDA receptor upon glutamate binding and postsynaptic events	0.873858523171251	-0.13483678923119	41	10	0.00309693403530505	3229	10285	1385,3265,818,5567,109,2890,1742,5894,2891,4747	CREB1,HRAS,CAMK2G,PRKACB,ADCY3,GRIA1,DLG4,RAF1,GRIA2,NEFL
R-HSA-111996	Ca-dependent events	0.877021289352311	-0.131224011702413	30	7	0.00216785382471353	3229	10285	1385,5153,109,108,5578,5567,5136	CREB1,PDE1B,ADCY3,ADCY2,PRKCA,PRKACB,PDE1A
R-HSA-73728	RNA Polymerase I Promoter Opening	0.879504129355118	-0.128397019698869	63	16	0.00495509445648808	3229	10285	3015,8335,85236,3013,474382,8350,94239,8345,8970,8342,3014,8348,8331,55766,255626,8334	H2AZ1,H2AC4,H2BC12,H2AC7,H2AB1,H3C1,H2AZ2,H2BC9,H2BC11,H2BC14,H2AX,H2BC17,H2AC14,H2AJ,H2BC1,H2AC6
R-HSA-73847	Purine metabolism	0.88224951191346	-0.125280369656199	34	8	0.00247754722824404	3229	10285	132,5471,8833,2876,159,1633,4860,22978	ADK,PPAT,GMPS,GPX1,ADSS2,DCK,PNP,NT5C2
R-HSA-1483166	Synthesis of PA	0.88224951191346	-0.125280369656199	34	8	0.00247754722824404	3229	10285	100137049,57678,8443,55326,81579,10554,51205,5322	PLA2G4B,GPAM,GNPAT,AGPAT5,PLA2G12A,AGPAT1,ACP6,PLA2G5
R-HSA-174824	Lipoprotein metabolism	0.884420243281035	-0.122822940978763	74	19	0.00588417466707959	3229	10285	160,1173,5567,10577,29801,3949,1175,51128,649,344,338328,29116,5045,255738,213,346,7376,7436,3988	AP2A1,AP2M1,PRKACB,NPC2,ZDHHC8,LDLR,AP2S1,SAR1B,BMP1,APOC2,GPIHBP1,MYLIP,FURIN,PCSK9,ALB,APOC4,NR1H2,VLDLR,LIPA
R-HSA-4420332	Defective B3GALT6 causes EDSP2 and SEMDJL1	0.892626226850052	-0.113587344684398	19	4	0.00123877361412202	3229	10285	6383,2239,2817,6385	SDC2,GPC4,GPC1,SDC4
R-HSA-5576886	Phase 4 - resting membrane potential	0.892626226850052	-0.113587344684398	19	4	0.00123877361412202	3229	10285	89822,56659,3759,54207	KCNK17,KCNK13,KCNJ2,KCNK10
R-HSA-3560783	Defective B4GALT7 causes EDS, progeroid type	0.892626226850052	-0.113587344684398	19	4	0.00123877361412202	3229	10285	2239,2817,6383,6385	GPC4,GPC1,SDC2,SDC4
R-HSA-416700	Other semaphorin interactions	0.892626226850052	-0.113587344684398	19	4	0.00123877361412202	3229	10285	8482,7305,10154,9037	SEMA7A,TYROBP,PLXNC1,SEMA5A
R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor	0.892626226850052	-0.113587344684398	19	4	0.00123877361412202	3229	10285	4747,818,1742,3265	NEFL,CAMK2G,DLG4,HRAS
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	0.892626226850052	-0.113587344684398	19	4	0.00123877361412202	3229	10285	917,919,920,26191	CD3G,CD247,CD4,PTPN22
R-HSA-3560801	Defective B3GAT3 causes JDSSDHD	0.892626226850052	-0.113587344684398	19	4	0.00123877361412202	3229	10285	2239,2817,6383,6385	GPC4,GPC1,SDC2,SDC4
R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.895103660661527	-0.110815745445941	27	6	0.00185816042118303	3229	10285	161742,9844,63916,3845,3265,200734	SPRED1,ELMO1,ELMO2,KRAS,HRAS,SPRED2
R-HSA-1482788	Acyl chain remodelling of PC	0.895103660661527	-0.110815745445941	27	6	0.00185816042118303	3229	10285	81579,11145,5322,50640,100137049,10162	PLA2G12A,PLAAT3,PLA2G5,PNPLA8,PLA2G4B,LPCAT3
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.89538285531575	-0.110503880872827	15	3	0.000929080210591514	3229	10285	6233,7311,7314	RPS27A,UBA52,UBB
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	0.89538285531575	-0.110503880872827	15	3	0.000929080210591514	3229	10285	7311,6233,7314	UBA52,RPS27A,UBB
R-HSA-77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	3030	HADHA
R-HSA-173623	Classical antibody-mediated complement activation	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	714	C1QC
R-HSA-1237112	Methionine salvage pathway	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	4507	MTAP
R-HSA-2142700	Synthesis of Lipoxins (LX)	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	241	ALOX5AP
R-HSA-6798163	Choline catabolism	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	55349	CHDH
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	1385	CREB1
R-HSA-5690714	CD22 mediated BCR regulation	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	974	CD79B
R-HSA-6799990	Metal sequestration by antimicrobial proteins	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	6279	S100A8
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	1856	DVL2
R-HSA-187015	Activation of TRKA receptors	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	4915	NTRK2
R-HSA-2187335	The retinoid cycle in cones (daylight vision)	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	9249	DHRS3
R-HSA-205025	NADE modulates death signalling	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	27018	BEX3
R-HSA-5339717	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	22943	DKK1
R-HSA-947581	Molybdenum cofactor biosynthesis	0.895807688084946	-0.11002952287811	6	1	0.000309693403530505	3229	10285	10243	GPHN
R-HSA-2129379	Molecules associated with elastic fibres	0.898107199467311	-0.107465842005874	31	7	0.00216785382471353	3229	10285	3685,4236,7043,3696,7042,3693,10516	ITGAV,MFAP1,TGFB3,ITGB8,TGFB2,ITGB5,FBLN5
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.898107199467311	-0.107465842005874	31	7	0.00216785382471353	3229	10285	10762,79023,57122,9972,129401,23636,11097	NUP50,NUP37,NUP107,NUP153,NUP35,NUP62,NUP42
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	0.901612814780858	-0.103570102980408	35	8	0.00247754722824404	3229	10285	5588,2342,23173,10988,5957,5145,2782,5578	PRKCQ,FNTB,METAP1,METAP2,RCVRN,PDE6A,GNB1,PRKCA
R-HSA-189451	Heme biosynthesis	0.904513198815285	-0.100358381864881	11	2	0.00061938680706101	3229	10285	3145,1352	HMBS,COX10
R-HSA-2485179	Activation of the phototransduction cascade	0.904513198815285	-0.100358381864881	11	2	0.00061938680706101	3229	10285	5145,2782	PDE6A,GNB1
R-HSA-418889	Ligand-independent caspase activation via DCC	0.904513198815285	-0.100358381864881	11	2	0.00061938680706101	3229	10285	1613,1612	DAPK3,DAPK1
R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	0.904513198815285	-0.100358381864881	11	2	0.00061938680706101	3229	10285	1141,1139	CHRNB2,CHRNA7
R-HSA-1638091	Heparan sulfate/heparin (HS-GAG) metabolism	0.907459392446217	-0.0971064604600302	54	13	0.00402601424589656	3229	10285	9653,2131,222537,11285,9348,9957,26035,3340,2817,6385,6383,2239,9955	HS2ST1,EXT1,HS3ST5,B4GALT7,NDST3,HS3ST1,GLCE,NDST1,GPC1,SDC4,SDC2,GPC4,HS3ST3A1
R-HSA-5334118	DNA methylation	0.908274130780755	-0.096209039799128	65	16	0.00495509445648808	3229	10285	55766,255626,8334,3014,8331,8348,8970,8342,8345,474382,8350,94239,3013,8335,85236,3015	H2AJ,H2BC1,H2AC6,H2AX,H2AC14,H2BC17,H2BC11,H2BC14,H2BC9,H2AB1,H3C1,H2AZ2,H2AC7,H2AC4,H2BC12,H2AZ1
R-HSA-5576892	Phase 0 - rapid depolarisation	0.913107447757125	-0.0909017188307098	47	11	0.00340662743883555	3229	10285	6327,55800,6324,10368,784,2257,783,2258,785,29098,818	SCN2B,SCN3B,SCN1B,CACNG3,CACNB3,FGF12,CACNB2,FGF13,CACNB4,RANGRF,CAMK2G
R-HSA-1483249	Inositol phosphate metabolism	0.913107447757125	-0.0909017188307098	47	11	0.00340662743883555	3229	10285	9807,5728,11165,3636,23236,5330,3613,4952,51477,11163,3631	IP6K1,PTEN,NUDT3,INPPL1,PLCB1,PLCB2,IMPA2,OCRL,ISYNA1,NUDT4,INPP4A
R-HSA-1483191	Synthesis of PC	0.914500730994426	-0.0893770118137275	28	6	0.00185816042118303	3229	10285	1120,1457,43,9468,56910,1460	CHKB,CSNK2A1,ACHE,PCYT1B,STARD7,CSNK2B
R-HSA-8874081	MET activates PTK2 signaling	0.915287095404891	-0.0885174974508807	20	4	0.00123877361412202	3229	10285	6714,3673,3913,4233	SRC,ITGA2,LAMB2,MET
R-HSA-1461973	Defensins	0.916928428090682	-0.0867258598364236	51	12	0.00371632084236606	3229	10285	245930,729230,1235,7097,245934,920,245937,1672,245928,7096,140881,245929	DEFB116,CCR2,CCR6,TLR2,DEFB121,CD4,DEFB124,DEFB1,DEFB114,TLR1,DEFB129,DEFB115
R-HSA-2514856	The phototransduction cascade	0.918210943561029	-0.0853281287442158	36	8	0.00247754722824404	3229	10285	5588,2342,23173,10988,5957,5145,2782,5578	PRKCQ,FNTB,METAP1,METAP2,RCVRN,PDE6A,GNB1,PRKCA
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.91960700228976	-0.0838088716269285	16	3	0.000929080210591514	3229	10285	7422,3815,94115	VEGFA,KIT,CGB8
R-HSA-163615	PKA activation	0.91960700228976	-0.0838088716269285	16	3	0.000929080210591514	3229	10285	5567,109,108	PRKACB,ADCY3,ADCY2
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.91960700228976	-0.0838088716269285	16	3	0.000929080210591514	3229	10285	3845,1839,3265	KRAS,HBEGF,HRAS
R-HSA-1442490	Collagen degradation	0.920763761986382	-0.0825517772724535	40	9	0.00278724063177454	3229	10285	1508,4323,5045,100126326,1513,9313,85007,4318,1509	CTSB,MMP14,FURIN,MIR936,CTSK,MMP20,PHYKPL,MMP9,CTSD
R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.925292355223126	-0.0776455317053805	106	27	0.00836172189532363	3229	10285	6513,7922,6529,1317,6515,4891,6005,148867,9376,6538,64924,51458,284111,9356,29985,57181,6530,6534,254428,6531,116085,6566,57127,6539,29988,6533,861	SLC2A1,SLC39A7,SLC6A1,SLC31A1,SLC2A3,SLC11A2,RHAG,SLC30A7,SLC22A8,SLC6A11,SLC30A5,RHCG,SLC13A5,SLC22A6,SLC39A3,SLC39A10,SLC6A2,SLC6A7,SLC41A1,SLC6A3,SLC22A12,SLC16A1,RHBG,SLC6A12,SLC2A8,SLC6A6,RUNX1
R-HSA-1912399	Pre-NOTCH Processing in the Endoplasmic Reticulum	0.928538204230542	-0.0741437528532594	7	1	0.000309693403530505	3229	10285	4853	NOTCH2
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	0.928538204230542	-0.0741437528532594	7	1	0.000309693403530505	3229	10285	1141	CHRNB2
R-HSA-420597	Nectin/Necl  trans heterodimerization	0.928538204230542	-0.0741437528532594	7	1	0.000309693403530505	3229	10285	5819	NECTIN2
R-HSA-426117	Cation-coupled Chloride cotransporters	0.928538204230542	-0.0741437528532594	7	1	0.000309693403530505	3229	10285	6558	SLC12A2
R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	0.928538204230542	-0.0741437528532594	7	1	0.000309693403530505	3229	10285	2030	SLC29A1
R-HSA-433692	Proton-coupled monocarboxylate transport	0.928538204230542	-0.0741437528532594	7	1	0.000309693403530505	3229	10285	6566	SLC16A1
R-HSA-75158	TRAIL  signaling	0.928538204230542	-0.0741437528532594	7	1	0.000309693403530505	3229	10285	8743	TNFSF10
R-HSA-5578768	Physiological factors	0.929548072364546	-0.0730567546377733	12	2	0.00061938680706101	3229	10285	4882,4880	NPR2,NPPC
R-HSA-4641265	Repression of WNT target genes	0.929548072364546	-0.0730567546377733	12	2	0.00061938680706101	3229	10285	7088,1487	TLE1,CTBP1
R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.929548072364546	-0.0730567546377733	12	2	0.00061938680706101	3229	10285	7157,8738	TP53,CRADD
R-HSA-8851680	Butyrophilin (BTN) family interactions	0.929548072364546	-0.0730567546377733	12	2	0.00061938680706101	3229	10285	10385,30835	BTN2A2,CD209
R-HSA-442742	CREB phosphorylation through the activation of Ras	0.930694515080524	-0.0718241811348777	29	6	0.00185816042118303	3229	10285	4747,5894,1742,1385,3265,818	NEFL,RAF1,DLG4,CREB1,HRAS,CAMK2G
R-HSA-977068	Termination of O-glycan biosynthesis	0.931288834001112	-0.0711858092170368	25	5	0.00154846701765252	3229	10285	256435,6482,6483,6484,6480	ST6GALNAC3,ST3GAL1,ST3GAL2,ST3GAL4,ST6GAL1
R-HSA-438064	Post NMDA receptor activation events	0.9323400238096	-0.0700576984179751	37	8	0.00247754722824404	3229	10285	1385,3265,818,5567,109,4747,5894,1742	CREB1,HRAS,CAMK2G,PRKACB,ADCY3,NEFL,RAF1,DLG4
R-HSA-2024096	HS-GAG degradation	0.93357110042026	-0.0687381534800594	21	4	0.00123877361412202	3229	10285	2239,2817,6383,6385	GPC4,GPC1,SDC2,SDC4
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	0.933616352416687	-0.068689682721146	107	27	0.00836172189532363	3229	10285	10991,23657,57282,117247,6575,54407,9498,6574,23428,11136,26503,6558,124935,115286,6546,6565,6539,6541,6564,140679,6533,6507,6717,1468,6505,6506,81539	SLC38A3,SLC7A11,SLC4A10,SLC16A10,SLC20A2,SLC38A2,SLC4A8,SLC20A1,SLC7A8,SLC7A9,SLC17A5,SLC12A2,SLC43A2,SLC25A26,SLC8A1,SLC15A2,SLC6A12,SLC7A1,SLC15A1,SLC32A1,SLC6A6,SLC1A3,SRI,SLC25A10,SLC1A1,SLC1A2,SLC38A1
R-HSA-425407	SLC-mediated transmembrane transport	0.934135701235851	-0.0681335609045131	287	79	0.0244657788789099	3229	10285	11136,6579,57122,23428,11097,57181,6538,64924,9498,54407,9376,389812,284111,6574,55343,6515,11309,6575,4891,23657,117247,7922,6513,92579,79023,1317,2030,6505,129401,3933,6506,6564,29988,84912,85414,286256,23169,6717,116085,10559,6565,28234,23636,6566,9972,57127,6558,6530,7355,254428,213,115286,124935,26503,29985,51458,148867,9356,6005,57282,8884,10762,10991,6529,28232,81539,861,6541,140679,6533,392399,1468,6507,6546,51000,6539,6534,6531,2542	SLC7A9,SLCO1A2,NUP107,SLC7A8,NUP42,SLC39A10,SLC6A11,SLC30A5,SLC4A8,SLC38A2,SLC22A8,LCN15,SLC13A5,SLC20A1,SLC35C1,SLC2A3,SLCO2B1,SLC20A2,SLC11A2,SLC7A11,SLC16A10,SLC39A7,SLC2A1,G6PC3,NUP37,SLC31A1,SLC29A1,SLC1A1,NUP35,LCN1,SLC1A2,SLC15A1,SLC2A8,SLC35B4,SLC45A3,LCN12,SLC35D1,SRI,SLC22A12,SLC35A1,SLC15A2,SLCO1B3,NUP62,SLC16A1,NUP153,RHBG,SLC12A2,SLC6A2,SLC35A2,SLC41A1,ALB,SLC25A26,SLC43A2,SLC17A5,SLC39A3,RHCG,SLC30A7,SLC22A6,RHAG,SLC4A10,SLC5A6,NUP50,SLC38A3,SLC6A1,SLCO3A1,SLC38A1,RUNX1,SLC7A1,SLC32A1,SLC6A6,LCN9,SLC25A10,SLC1A3,SLC8A1,SLC35B3,SLC6A12,SLC6A7,SLC6A3,SLC37A4
R-HSA-1482922	Acyl chain remodelling of PI	0.938594597944088	-0.0633716310783062	17	3	0.000929080210591514	3229	10285	5322,11145,81579	PLA2G5,PLAAT3,PLA2G12A
R-HSA-164378	PKA activation in glucagon signalling	0.938594597944088	-0.0633716310783062	17	3	0.000929080210591514	3229	10285	5567,109,108	PRKACB,ADCY3,ADCY2
R-HSA-445095	Interaction between L1 and Ankyrins	0.944112821523694	-0.057509605651957	30	6	0.00185816042118303	3229	10285	6711,6327,6709,3897,55800,6324	SPTBN1,SCN2B,SPTAN1,L1CAM,SCN3B,SCN1B
R-HSA-1971475	A tetrasaccharide linker sequence is required for GAG synthesis	0.945391470199068	-0.0561561830890603	26	5	0.00154846701765252	3229	10285	6383,2817,2239,11285,6385	SDC2,GPC1,GPC4,B4GALT7,SDC4
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.945813693894991	-0.0557096702400535	76	18	0.00557448126354909	3229	10285	27018,6655,5664,7189,7410,23385,7074,55851,26574,572,9459,84904,6233,7311,8878,221472,7314,51107	BEX3,SOS2,PSEN2,TRAF6,VAV2,NCSTN,TIAM1,PSENEN,AATF,BAD,ARHGEF6,ARHGEF39,RPS27A,UBA52,SQSTM1,FGD2,UBB,APH1A
R-HSA-397014	Muscle contraction	0.947734835891582	-0.0536805248280906	204	54	0.0167234437906473	3229	10285	6546,5350,55800,80228,103910,29098,7125,3767,7170,4882,1674,6327,483,6786,29767,89822,7135,7220,56659,10768,4880,29766,7139,3759,3751,6324,859,30819,54207,3752,1760,785,493,2257,7111,3693,2281,476,10627,8557,6717,10368,30818,818,2258,481,1193,784,477,53826,59,478,783,4637	SLC8A1,PLN,SCN3B,ORAI2,MYL12B,RANGRF,TNNC2,KCNJ11,TPM3,NPR2,DES,SCN2B,ATP1B3,STIM1,TMOD2,KCNK17,TNNI1,TRPC1,KCNK13,AHCYL1,NPPC,TMOD3,TNNT2,KCNJ2,KCND2,SCN1B,CAV3,KCNIP2,KCNK10,KCND3,DMPK,CACNB4,ATP2B4,FGF12,TMOD1,ITGB5,FKBP1B,ATP1A1,MYL12A,TCAP,SRI,CACNG3,KCNIP3,CAMK2G,FGF13,ATP1B1,CLIC2,CACNB3,ATP1A2,FXYD6,ACTA2,ATP1A3,CACNB2,MYL6
R-HSA-425561	Sodium/Calcium exchangers	0.948279863794774	-0.0531056053210906	13	2	0.00061938680706101	3229	10285	6717,6546	SRI,SLC8A1
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	0.948279863794774	-0.0531056053210906	13	2	0.00061938680706101	3229	10285	5530,10768	PPP3CA,AHCYL1
R-HSA-189200	Hexose transport	0.949444182389362	-0.0518785367775673	54	12	0.00371632084236606	3229	10285	6515,9972,23636,6513,10762,79023,92579,2542,57122,11097,129401,85414	SLC2A3,NUP153,NUP62,SLC2A1,NUP50,NUP37,G6PC3,SLC37A4,NUP107,NUP42,NUP35,SLC45A3
R-HSA-5632681	Ligand-receptor interactions	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	64399	HHIP
R-HSA-389397	Orexin and neuropeptides FF and QRFP bind to their respective receptors	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	3060	HCRT
R-HSA-416550	Sema4D mediated inhibition of cell attachment and migration	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	4233	MET
R-HSA-448424	Interleukin-17 signaling	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	112744	IL17F
R-HSA-2142789	Ubiquinol biosynthesis	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	57107	PDSS2
R-HSA-6787450	tRNA modification in the mitochondrion	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	3028	HSD17B10
R-HSA-77111	Synthesis of Ketone Bodies	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	38	ACAT1
R-HSA-1483115	Hydrolysis of LPC	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	100137049	PLA2G4B
R-HSA-70921	Histidine catabolism	0.950989083630767	-0.05025269533463	8	1	0.000309693403530505	3229	10285	3176	HNMT
R-HSA-1482925	Acyl chain remodelling of PG	0.953352947685924	-0.0477700895522757	18	3	0.000929080210591514	3229	10285	5322,100137049,81579	PLA2G5,PLA2G4B,PLA2G12A
R-HSA-5635838	Activation of SMO	0.953352947685924	-0.0477700895522757	18	3	0.000929080210591514	3229	10285	84455,1452,2622	EFCAB7,CSNK1A1,GAS8
R-HSA-6783310	Fanconi Anemia Pathway	0.95433173422498	-0.0467439381822673	39	8	0.00247754722824404	3229	10285	7314,80233,6118,548593,7311,6119,2189,6233	UBB,FAAP100,RPA2,SLX1A,UBA52,RPA3,FANCG,RPS27A
R-HSA-1500620	Meiosis	0.955237172483086	-0.0457956211848758	121	30	0.00929080210591514	3229	10285	6118,8342,8970,3014,8348,55766,3015,1019,3013,56158,27030,94239,8350,474382,4000,8345,4001,5932,644186,84057,8331,255626,5885,8334,7329,4683,672,85236,8335,6119	RPA2,H2BC14,H2BC11,H2AX,H2BC17,H2AJ,H2AZ1,CDK4,H2AC7,TEX12,MLH3,H2AZ2,H3C1,H2AB1,LMNA,H2BC9,LMNB1,RBBP8,SYCE3,MND1,H2AC14,H2BC1,RAD21,H2AC6,UBE2I,NBN,BRCA1,H2BC12,H2AC4,RPA3
R-HSA-114508	Effects of PIP2 hydrolysis	0.956820517804141	-0.0441394518224024	27	5	0.00154846701765252	3229	10285	10235,5581,57406,26090,5588	RASGRP2,PRKCE,ABHD6,ABHD12,PRKCQ
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.956820517804141	-0.0441394518224024	27	5	0.00154846701765252	3229	10285	5932,116028,672,80010,4683	RBBP8,RMI2,BRCA1,RMI1,NBN
R-HSA-1483206	Glycerophospholipid biosynthesis	0.959486093069462	-0.0413574575743221	129	32	0.00991018891297615	3229	10285	8904,9468,85465,10554,23760,3030,114882,9489,11145,23646,114971,81579,56910,10423,50640,1457,43,55349,5322,10162,55326,1460,9791,8443,63874,51205,117245,6901,55224,1120,100137049,57678	CPNE1,PCYT1B,SELENOI,AGPAT1,PITPNB,HADHA,OSBPL8,PGS1,PLAAT3,PLD3,PTPMT1,PLA2G12A,STARD7,CDIPT,PNPLA8,CSNK2A1,ACHE,CHDH,PLA2G5,LPCAT3,AGPAT5,CSNK2B,PTDSS1,GNPAT,ABHD4,ACP6,PLAAT5,TAFAZZIN,ETNK2,CHKB,PLA2G4B,GPAM
R-HSA-389977	Post-chaperonin tubulin folding pathway	0.959816022474255	-0.0410136561421545	23	4	0.00123877361412202	3229	10285	6905,7846,10376,10383	TBCE,TUBA1A,TUBA1B,TUBB4B
R-HSA-181431	Acetylcholine Binding And Downstream Events	0.962197561715587	-0.0385354837923423	14	2	0.00061938680706101	3229	10285	1139,1141	CHRNA7,CHRNB2
R-HSA-622327	Postsynaptic nicotinic acetylcholine receptors	0.962197561715587	-0.0385354837923423	14	2	0.00061938680706101	3229	10285	1139,1141	CHRNA7,CHRNB2
R-HSA-629602	Activation of Nicotinic Acetylcholine Receptors	0.962197561715587	-0.0385354837923423	14	2	0.00061938680706101	3229	10285	1141,1139	CHRNB2,CHRNA7
R-HSA-2024101	CS/DS degradation	0.962197561715587	-0.0385354837923423	14	2	0.00061938680706101	3229	10285	3074,3073	HEXB,HEXA
R-HSA-6803157	Antimicrobial peptides	0.962599223834238	-0.0381181284356654	97	23	0.00712294828120161	3229	10285	245929,149954,7096,4069,140683,245934,7097,5266,140881,820,92747,116842,920,1672,245937,245930,6039,1113,245928,1191,6279,729230,1235	DEFB115,BPIFB4,TLR1,LYZ,BPIFA2,DEFB121,TLR2,PI3,DEFB129,CAMP,BPIFB1,LEAP2,CD4,DEFB1,DEFB124,DEFB116,RNASE6,CHGA,DEFB114,CLU,S100A8,CCR2,CCR6
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	0.962730064480108	-0.0379822133515657	44	9	0.00278724063177454	3229	10285	1428,5092,2184,85007,1743,89874,3176,80150,3620	CRYM,PCBD1,FAH,PHYKPL,DLST,SLC25A21,HNMT,ASRGL1,IDO1
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	0.963058266964689	-0.0376413633397549	48	10	0.00309693403530505	3229	10285	2155,8841,6604,1387,2033,5465,1385,4783,1407,8553	F7,HDAC3,SMARCD3,CREBBP,EP300,PPARA,CREB1,NFIL3,CRY1,BHLHE40
R-HSA-445355	Smooth Muscle Contraction	0.963154749764045	-0.0375411845966992	36	7	0.00216785382471353	3229	10285	7170,4637,3693,10627,103910,59,859	TPM3,MYL6,ITGB5,MYL12A,MYL12B,ACTA2,CAV3
R-HSA-1368082	RORA activates gene expression	0.966020471463539	-0.0345702530029245	28	5	0.00154846701765252	3229	10285	6604,1387,2033,5465,8841	SMARCD3,CREBBP,EP300,PPARA,HDAC3
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.966020471463539	-0.0345702530029245	28	5	0.00154846701765252	3229	10285	5728,5330,4952,3636,23236	PTEN,PLCB2,OCRL,INPPL1,PLCB1
R-HSA-174800	Chylomicron-mediated lipid transport	0.966020471463539	-0.0345702530029245	28	5	0.00154846701765252	3229	10285	338328,344,3949,5045,51128	GPIHBP1,APOC2,LDLR,FURIN,SAR1B
R-HSA-2474795	Diseases associated with visual transduction	0.966388154277814	-0.0341897094534764	9	1	0.000309693403530505	3229	10285	7276	TTR
R-HSA-1462054	Alpha-defensins	0.966388154277814	-0.0341897094534764	9	1	0.000309693403530505	3229	10285	920	CD4
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	0.966388154277814	-0.0341897094534764	9	1	0.000309693403530505	3229	10285	1141	CHRNB2
R-HSA-2453864	Retinoid cycle disease events	0.966388154277814	-0.0341897094534764	9	1	0.000309693403530505	3229	10285	7276	TTR
R-HSA-166665	Terminal pathway of complement	0.966388154277814	-0.0341897094534764	9	1	0.000309693403530505	3229	10285	1191	CLU
R-HSA-189085	Digestion of dietary carbohydrate	0.966388154277814	-0.0341897094534764	9	1	0.000309693403530505	3229	10285	280	AMY2B
R-HSA-2243919	Crosslinking of collagen fibrils	0.966388154277814	-0.0341897094534764	9	1	0.000309693403530505	3229	10285	649	BMP1
R-HSA-388396	GPCR downstream signaling	0.967427090798439	-0.0331152152656499	974	281	0.0870238463920718	3229	10285	221472,390152,2788,219959,5732,10563,390433,6019,117579,7433,55970,120775,5153,338675,3355,5294,79290,84432,390260,108,219875,57406,6364,4986,5028,124538,256933,259292,7852,219870,1230,7410,187,390265,283869,154,3717,341418,51738,6870,148,2918,6370,2840,5142,3559,2847,1812,390429,57007,6368,319100,134,26090,4992,10888,3627,219960,27198,401666,4987,1236,26534,208,2838,8862,2776,9170,4889,10663,119772,26648,50833,390436,390199,3716,5731,5579,5581,2784,2793,403253,1437,8698,7253,92840,2767,2550,50838,5032,5539,442191,2147,5151,8490,6093,26339,6750,155,51764,6001,442361,153,2787,50837,10161,6366,221035,3561,5296,4988,219981,3562,2837,4283,4852,6387,1268,441669,283297,442186,6464,406974,11245,5173,3361,80346,27334,207,50865,5290,9630,2791,729230,390162,1234,390195,7432,3576,26211,1131,5578,1232,122042,2833,3060,219865,54331,553,283694,8477,26686,341152,680,5330,64108,5737,259285,3558,84539,6869,10911,392138,6863,2919,1394,109,441639,387129,4829,5295,121364,6363,219431,81285,10287,125963,219986,219983,64805,1909,3577,54429,59345,5138,9459,79924,26493,3274,5880,390648,2785,2921,84904,5744,441670,9628,390437,390059,259286,2771,219954,120787,8503,26692,1132,441608,10235,219858,5997,10850,113091,2782,390431,5588,7074,134864,1133,390093,6375,125958,9475,138802,390261,6373,2831,56477,121130,119692,3356,5136,1814,2790,10798,23236,391,6352,4887,998,5030,1902,120586,2911,2797,5368,2912,219437,11255,5150,4295,5996,81696,7932,1128,5021,3972,170589,114814,2773,10000,10268,134083,119765,1233,79544,388,1235,3567,390157,26533,5734,2796,3560,140,6655,3350,151306,2925,283162,2781,4886	FGD2,OR8H3,GNG7,OR1S1,PTGER2,CXCL13,OR4K13,RLN2,RLN3,VIPR1,GNG12,OR2D3,PDE1B,OR5AP2,HTR1F,PIK3CG,OR13A1,PROK1,OR6X1,ADCY2,OR4D5,ABHD6,CCL20,OPRK1,P2RY1,OR4D2,NPB,TAS2R46,CXCR4,OR10G9,CCR1,VAV2,APLNR,OR10G7,NPW,ADRB2,JAK2,OR6C4,GHRL,TACR3,ADRA1A,GRM8,CCL25,GPR17,PDE4B,IL2RA,MCHR1,DRD1,OR4N2,ACKR3,CCL23,TAAR6,ADORA1,ABHD12,OR1F1,GPR83,CXCL10,OR10Q1,HCAR1,OR51A4,OPRL1,CCR7,OR10G2,AKT2,GPR15,APLN,GNAQ,LPAR2,NPY5R,CXCR6,OR52M1,OR7E24,TAS2R16,OR4K17,OR4D9,JAK1,PTGER1,PRKCB,PRKCE,GNB3,GNGT2,OR4A47,CSF2,S1PR4,TSHR,REEP6,GNA11,GABBR1,TAS2R13,P2RY11,PPY,OR14J1,F2,PDE8A,RGS5,ROCK1,OR5K1,SST,ADRB3,GNG13,RGS10,OR2A2,ADRB1,GNG5,TAS2R7,LPAR6,CCL21,REEP3,IL2RG,PIK3R2,OPRM1,OR5A2,IL3,UTS2R,CXCL9,NPY,CXCL12,CNR1,OR4Q3,OR10A4,OR2J3,SHC1,MIR197,GPR176,PDYN,HTR5A,REEP4,P2RY10,AKT1,HEBP1,PIK3CA,GNA14,GNG11,CCR2,OR5M9,CCR5,OR5AN1,VIP,CXCL8,OR2F1,CHRM3,PRKCA,CCR3,RXFP2,CXCR3,HCRT,OR8G5,GNG2,AVPR1B,OR4N4,GPR65,OR4E2,OR2AT4,BRS3,PLCB2,RTP4,PTGFR,TAS2R39,IL2,MCHR2,TACR1,UTS2,OR2A25,TAC1,CXCL1,CRHR1,ADCY3,OR9K2,NPSR1,NMBR,PIK3R1,OR10A7,CCL19,OR4S2,OR51E2,RGS19,OR1M1,OR4D11,OR4D6,P2RY12,EDNRA,CXCR1,TAS2R5,GNB4,PDE2A,ARHGEF6,ADM2,OR8B8,HRH2,RAC2,OR4F6,GNG3,CXCL3,ARHGEF39,PTHLH,OR4M1,RGS6,OR4N5,OR51M1,TAS2R40,GNAI2,OR9I1,OR52W1,PIK3R3,OR2W1,CHRM4,OR5B3,RASGRP2,OR8B12,RGS2,CCL27,PTH2,GNB1,OR4K2,PRKCQ,TIAM1,TAAR1,CHRM5,OR10A6,XCL1,OR7D4,ROCK2,OR13C8,OR6M1,CXCL11,NPBWR1,CCL28,OR10P1,OR51S1,HTR2A,PDE1A,DRD3,GNG10,OR5I1,PLCB1,RHOG,CCL5,NPY2R,CDC42,P2RY4,LPAR1,OR8I2,GRM1,GNRH2,PNOC,GRM2,OR5L1,HRH3,PDE7A,MLN,RGS1,OR5V1,OR2H2,CHRM1,OXTR,LHB,GPHA2,GNRHR2,GNAI3,AKT3,RAMP3,OR2Y1,OR4B1,CCR4,OR4K1,RHOB,CCR6,IL5,OR8K1,OR10G3,PTGER4,GNRH1,IL2RB,ADORA3,SOS2,HTR1A,GPBAR1,GRPR,OR8B4,GNAZ,NPY1R
R-HSA-913709	O-linked glycosylation of mucins	0.971487832750757	-0.0289265344316894	65	14	0.00433570764942707	3229	10285	9331,79695,2589,6483,9245,64409,6482,29071,256435,10678,6480,6484,8693,2590	B4GALT6,GALNT12,GALNT1,ST3GAL2,GCNT3,GALNT17,ST3GAL1,C1GALT1C1,ST6GALNAC3,B3GNT2,ST6GAL1,ST3GAL4,GALNT4,GALNT2
R-HSA-936837	Ion transport by P-type ATPases	0.975219248257613	-0.0250929632559527	58	12	0.00371632084236606	3229	10285	478,27032,483,6717,10396,53826,477,476,481,493,818,5350	ATP1A3,ATP2C1,ATP1B3,SRI,ATP8A1,FXYD6,ATP1A2,ATP1A1,ATP1B1,ATP2B4,CAMK2G,PLN
R-HSA-1566948	Elastic fibre formation	0.975463318933625	-0.0248427219492522	42	8	0.00247754722824404	3229	10285	3693,7042,10516,5045,3685,3696,4236,7043	ITGB5,TGFB2,FBLN5,FURIN,ITGAV,ITGB8,MFAP1,TGFB3
R-HSA-3000157	Laminin interactions	0.976154895253076	-0.0241340010084746	25	4	0.00123877361412202	3229	10285	3673,3685,3913,3655	ITGA2,ITGAV,LAMB2,ITGA6
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.977443818497662	-0.022814463457048	34	6	0.00185816042118303	3229	10285	672,80010,4683,548593,116028,5932	BRCA1,RMI1,NBN,SLX1A,RMI2,RBBP8
R-HSA-1266738	Developmental Biology	0.978564810575971	-0.0216682597191137	1075	309	0.095695261690926	3229	10285	9439,94239,8503,203190,3013,9314,2252,3015,59277,11313,783,1175,4637,55090,5906,4478,4205,5928,1173,5438,1741,1839,785,9861,1496,5721,55588,23389,6324,5880,200734,55997,255626,4747,11221,1475,1739,8350,5295,83896,2817,5695,1385,5709,7703,2051,5468,5693,90390,5684,5699,3558,7305,5705,3725,4087,8348,1785,57472,8315,1445,1742,1020,3952,5664,5536,9442,23385,8822,25818,1944,5713,55800,6604,6383,3221,400569,3312,5567,5578,2043,6655,818,474382,386684,55816,3560,1272,784,8823,823,55851,57144,10094,7450,29079,3567,388,2549,28956,3815,5687,10000,8829,1024,5621,5692,9967,1041,7422,220164,10154,1843,3211,7979,8334,5080,10627,5702,100271849,161742,1072,6233,1947,5931,7480,10589,5525,391,998,7529,6804,5686,10486,3856,8074,4756,1400,7525,5691,5037,5529,160,103910,1852,6714,9475,10817,2255,2033,7074,8502,84246,5436,4088,5908,5588,1946,5266,85285,84292,7311,5460,55715,6327,1437,9412,8976,285704,9350,8851,5718,4014,3716,55766,208,130399,8726,3014,53358,9211,5465,2248,3559,51003,5698,2167,1457,8331,4296,116986,3728,3673,8345,5689,3717,1460,5704,1019,7410,6657,27086,2260,122706,3855,5685,56924,9440,8970,5683,5694,284,5720,6711,79447,85236,4690,5781,6478,5435,4208,10213,5518,7124,7314,91,5433,3516,5441,643394,8649,5608,5045,7903,6928,5700,8452,1387,4089,337879,8506,8986,5432,3265,5516,207,8682,5290,3320,5707,5690,1495,5062,1969,6464,25780,896,8335,56963,8841,5682,10109,1499,214,10368,9037,5245,5710,3562,3685,2146,1959,3897,8482,3326,5296,3561,5306,6699,2246,2887,1848,7220,60,9370,10097,152559,6477,4790,4233,6837,3171,51107,8342,6900,27022,6709,6386,5716,948,4318,6093,5431,3845,5604,5316,5894,5652,27006	MED23,H2AZ2,PIK3R3,LGI3,H2AC7,KLF4,FGF7,H2AZ1,NTN4,LYPLA2,CACNB2,AP2S1,MYL6,MED9,RAP1A,MSN,MEF2A,RBBP4,AP2M1,POLR2I,DLG3,HBEGF,CACNB4,PSMD6,CTNNA2,PSME2,MED29,MED13L,SCN1B,RAC2,SPRED2,CFC1,H2BC1,NEFL,DUSP10,CSTA,DLG1,H3C1,PIK3R1,KRTAP3-1,GPC1,PSMB7,CREB1,PSMD3,PCGF2,EPHB6,PPARG,PSMB5,MED30,PSMA3,PSMB10,IL2,TYROBP,PSMC5,JUN,SMAD2,H2BC17,DNM2,CNOT6,BRAP,CSK,DLG4,CDK5,LEP,PSEN2,PPP5C,MED27,NCSTN,FGF17,KLK5,EFNA3,PSMD7,SCN3B,SMARCD3,SDC2,HOXC4,MED11,HSPA8,PRKACB,PRKCA,EPHA4,SOS2,CAMK2G,H2AB1,KRTAP12-4,DOK5,IL2RB,CNTN1,CACNB3,FGF16,CAPN1,PSENEN,PAK5,ARPC3,VWF,MED4,IL5,RHOB,GAB1,LAMTOR2,KIT,PSMA6,AKT3,NRP1,CDK8,PRNP,PSMB4,THRAP3,CDSN,VEGFA,DOK6,PLXNC1,DUSP1,HOXB1,SEM1,H2AC6,PAX6,MYL12A,PSMC3,MEF2B,SPRED1,CFL1,RPS27A,EFNB1,RBBP7,WNT10B,DRAP1,PPP2R5A,RHOG,CDC42,YWHAB,STX1A,PSMA5,CAP2,KRT8,FGF23,NEO1,CRMP1,YES1,PSMB3,PEBP1,PPP2R5E,AP2A1,MYL12B,DUSP9,SRC,ROCK2,FRS3,FGF10,EP300,TIAM1,PKP4,MED10,POLR2G,SMAD3,RAP1B,PRKCQ,EFNA5,PI3,KRTAP4-1,WDR83,UBA52,POU5F1,DOK4,SCN2B,CSF2,MED21,WASL,RGMB,CER1,CDK5R1,PSMD12,LORICRIN,JAK1,H2AJ,AKT2,ACVR1C,EED,H2AX,SHC3,LGI1,PPARA,FGF3,IL2RA,MED31,PSMB9,FABP4,CSNK2A1,H2AC14,MAP3K11,AGAP2,JUP,ITGA2,H2BC9,PSMB1,JAK2,CSNK2B,PSMC4,CDK4,VAV2,SOX2,FOXP1,FGFR1,PSMB11,KRT7,PSMA4,PAK6,MED17,H2BC11,PSMA2,PSMB6,ANGPT1,PSME1,SPTBN1,PAGR1,H2BC12,NCK1,PTPN11,SIAH2,POLR2F,MEF2C,PSMD14,PPP2R1A,TNF,UBB,ACVR1B,POLR2D,RBPJ,POLR2L,SPINK9,LAMTOR3,MAP2K6,FURIN,ST8SIA4,HNF1B,PSMC1,CUL3,CREBBP,SMAD4,KRTAP8-1,CNTNAP1,RPS6KA4,POLR2C,HRAS,PPP2CB,AKT1,PEA15,PIK3CA,HSP90AA1,PSMD1,PSMB2,CTNNA1,PAK2,EPHA2,SHC1,RASGRP3,CCND3,H2AC4,RGMA,HDAC3,PSMA1,ARPC2,CTNNB1,ALCAM,CACNG3,SEMA5A,PHB1,PSMD4,IL3,ITGAV,EZH2,EGR2,L1CAM,SEMA7A,HSP90AB1,PIK3R2,IL2RG,PITPNA,SPRR1B,FGF1,GRB10,DUSP6,TRPC1,ACTB,ADIPOQ,ACTR2,PAQR3,SIAH1,NFKB1,MET,MED22,FOXA3,APH1A,H2BC14,CNTN2,FOXD3,SPTAN1,SDCBP,PSMD10,CD36,MMP9,ROCK1,POLR2B,KRAS,MAP2K1,PKNOX1,RAF1,PRSS8,FGF22
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.978921670676001	-0.021303649176562	156	38	0.0117683493341592	3229	10285	29127,10938,3796,3440,3665,1020,3797,3717,4097,3447,55669,8350,3661,998,23028,3446,9371,3660,1387,5868,7157,10749,64837,5567,25942,4778,23468,829,830,3659,8165,3043,3046,30845,51317,50808,2033,3456	RACGAP1,EHD1,KIF2A,IFNA2,IRF7,CDK5,KIF3C,JAK2,MAFG,IFNA13,MFN1,H3C1,IRF3,CDC42,KDM1A,IFNA10,KIF3B,IRF2,CREBBP,RAB5A,TP53,KIF1C,KLC2,PRKACB,SIN3A,NFE2,CBX5,CAPZA1,CAPZA2,IRF1,AKAP1,HBB,HBE1,EHD3,PHF21A,AK3,EP300,IFNB1
R-HSA-5693537	Resolution of D-Loop Structures	0.982208261693067	-0.0179519139960923	35	6	0.00185816042118303	3229	10285	80010,4683,672,5932,548593,116028	RMI1,NBN,BRCA1,RBBP8,SLX1A,RMI2
R-HSA-216083	Integrin cell surface interactions	0.983239858986479	-0.0169021814925595	68	14	0.00433570764942707	3229	10285	3696,50848,3384,4060,3693,6696,3685,3383,3673,8174,3655,1605,961,3385	ITGB8,F11R,ICAM2,LUM,ITGB5,SPP1,ITGAV,ICAM1,ITGA2,MADCAM1,ITGA6,DAG1,CD47,ICAM3
R-HSA-418360	Platelet calcium homeostasis	0.983864128991965	-0.016267471756563	31	5	0.00154846701765252	3229	10285	6546,493,6786,6717,80228	SLC8A1,ATP2B4,STIM1,SRI,ORAI2
R-HSA-2470946	Cohesin Loading onto Chromatin	0.984193586246278	-0.0159326672893575	11	1	0.000309693403530505	3229	10285	5885	RAD21
R-HSA-549127	Organic cation transport	0.984193586246278	-0.0159326672893575	11	1	0.000309693403530505	3229	10285	861	RUNX1
R-HSA-2022923	Dermatan sulfate biosynthesis	0.984193586246278	-0.0159326672893575	11	1	0.000309693403530505	3229	10285	10090	UST
R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.984193586246278	-0.0159326672893575	11	1	0.000309693403530505	3229	10285	1499	CTNNB1
R-HSA-166663	Initial triggering of complement	0.985154449111987	-0.0149568489731392	22	3	0.000929080210591514	3229	10285	2220,4153,714	FCN2,MBL2,C1QC
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	0.985303489669298	-0.0148055739272103	92	20	0.0061938680706101	3229	10285	257194,338328,284098,503542,249,5279,7070,10026,23627,5277,84628,390243,8733,1043,1048,4062,51299,80740,2350,8818	NEGR1,GPIHBP1,PIGW,SPRN,ALPL,PIGC,THY1,PIGK,PRND,PIGA,NTNG2,IZUMO1R,GPAA1,CD52,CEACAM5,LY6H,NRN1,LY6G6C,FOLR2,DPM2
R-HSA-194315	Signaling by Rho GTPases	0.985490813297628	-0.0146154743022906	426	114	0.0353050480024775	3229	10285	29127,3014,4637,9886,7532,55766,401541,354,392,84904,22919,94134,7514,57122,3013,79023,8976,51306,94239,3015,1080,4771,8331,348235,64837,255626,9459,8345,57584,79003,64130,79019,5880,9938,8348,399,147841,2810,58480,9184,51517,8970,1742,220134,991,8350,7410,1027,55789,221472,5518,4952,79980,10810,4690,90627,85236,388,5516,30851,3796,26999,10787,4085,80776,6655,474382,1856,10403,2665,10094,1499,8334,10109,5501,367,5062,1495,619553,83540,394,8335,91687,10097,1124,2017,5529,4983,84986,8342,6242,5296,54820,60,332,23028,7529,998,391,5525,23002,6396,4659,7533,5500,6714,9475,103910,57381,7074,7534,6093,5048,55843	RACGAP1,H2AX,MYL6,RHOBTB1,YWHAG,H2AJ,CENPP,KLK3,ARHGAP1,ARHGEF39,MAPRE1,ARHGAP12,XPO1,NUP107,H2AC7,NUP37,WASL,FAM13B,H2AZ2,H2AZ1,CFTR,NF2,H2AC14,SKA2,KLC2,H2BC1,ARHGEF6,H2BC9,ARHGAP21,MIS12,LIN7B,CENPM,RAC2,ARHGAP25,H2BC17,RHOH,SPC24,SFN,RHOU,BUB3,NCKIPSD,H2BC11,DLG4,SKA1,CDC20,H3C1,VAV2,CDKN1B,DEPDC1B,FGD2,PPP2R1A,OCRL,DSN1,WASF3,NCK1,STARD13,H2BC12,RHOB,PPP2CB,TAX1BP3,KIF2A,CYFIP2,NCKAP1,MAD2L1,B9D2,SOS2,H2AB1,DVL2,NDC80,GDI2,ARPC3,CTNNB1,H2AC6,ARPC2,PPP1CC,AR,PAK2,CTNNA1,MIR484,NUF2,ARHGAP5,H2AC4,CENPL,ACTR2,CHN2,CTTN,PPP2R5E,OPHN1,ARHGAP19,H2BC14,RTKN,PIK3R2,NDE1,ACTB,BIRC5,KDM1A,YWHAB,CDC42,RHOG,PPP2R5A,DAAM1,SEC13,PPP1R12A,YWHAH,PPP1CB,SRC,ROCK2,MYL12B,RHOJ,TIAM1,YWHAZ,ROCK1,PAFAH1B1,ARHGAP15
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	0.98555423073178	-0.0145511252562185	17	2	0.00061938680706101	3229	10285	8884,60496	SLC5A6,AASDHPPT
R-HSA-139853	Elevation of cytosolic Ca2+ levels	0.98555423073178	-0.0145511252562185	17	2	0.00061938680706101	3229	10285	6786,80228	STIM1,ORAI2
R-HSA-3000178	ECM proteoglycans	0.986083833763565	-0.0140139038928674	57	11	0.00340662743883555	3229	10285	7143,8785,3693,7042,1605,3685,3673,4060,3913,7043,2331	TNR,MATN4,ITGB5,TGFB2,DAG1,ITGAV,ITGA2,LUM,LAMB2,TGFB3,FMOD
R-HSA-419037	NCAM1 interactions	0.989052663100258	-0.0110076999396234	37	6	0.00185816042118303	3229	10285	5621,6900,783,785,784,7903	PRNP,CNTN2,CACNB2,CACNB4,CACNB3,ST8SIA4
R-HSA-622323	Presynaptic nicotinic acetylcholine receptors	0.98916136025992	-0.0108978057032186	12	1	0.000309693403530505	3229	10285	1141	CHRNB2
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.98916136025992	-0.0108978057032186	12	1	0.000309693403530505	3229	10285	5885	RAD21
R-HSA-73621	Pyrimidine catabolism	0.98916136025992	-0.0108978057032186	12	1	0.000309693403530505	3229	10285	51251	NT5C3A
R-HSA-1236977	Endosomal/Vacuolar pathway	0.98916136025992	-0.0108978057032186	12	1	0.000309693403530505	3229	10285	567	B2M
R-HSA-5576893	Phase 2 - plateau phase	0.989427340631563	-0.0106289470231648	28	4	0.00123877361412202	3229	10285	783,785,784,10368	CACNB2,CACNB4,CACNB3,CACNG3
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	0.992568151635692	-0.00745960214277881	13	1	0.000309693403530505	3229	10285	5880	RAC2
R-HSA-71240	Tryptophan catabolism	0.992568151635692	-0.00745960214277881	13	1	0.000309693403530505	3229	10285	3620	IDO1
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.992568151635692	-0.00745960214277881	13	1	0.000309693403530505	3229	10285	1839	HBEGF
R-HSA-5683826	Surfactant metabolism	0.993958202802489	-0.00606012270414535	30	4	0.00123877361412202	3229	10285	653509,6441,6440,643847	SFTPA1,SFTPD,SFTPC,PGA4
R-HSA-166658	Complement cascade	0.995422743951647	-0.00458776376140865	45	7	0.00216785382471353	3229	10285	966,5627,2220,4179,4153,714,1191	CD59,PROS1,FCN2,CD46,MBL2,C1QC,CLU
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.99650632254777	-0.0034997945950053	15	1	0.000309693403530505	3229	10285	8829	NRP1
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.99650632254777	-0.0034997945950053	15	1	0.000309693403530505	3229	10285	5885	RAD21
R-HSA-6785631	ERBB2 Regulates Cell Motility	0.99650632254777	-0.0034997945950053	15	1	0.000309693403530505	3229	10285	1839	HBEGF
R-HSA-5083635	Defective B3GALTL causes Peters-plus syndrome (PpS)	0.996695868531884	-0.00330960216441892	37	5	0.00154846701765252	3229	10285	10418,9510,9037,81794,80070	SPON1,ADAMTS1,SEMA5A,ADAMTS10,ADAMTS20
R-HSA-977606	Regulation of Complement cascade	0.9967162036148	-0.00328919987710442	27	3	0.000929080210591514	3229	10285	4179,966,5627	CD46,CD59,PROS1
R-HSA-983189	Kinesins	0.996928758694297	-0.00307596724609783	42	6	0.00185816042118303	3229	10285	9371,3797,3796,64837,29127,10749	KIF3B,KIF3C,KIF2A,KLC2,RACGAP1,KIF1C
R-HSA-5173105	O-linked glycosylation	0.997430377169567	-0.00257292997780739	114	23	0.00712294828120161	3229	10285	8693,81794,2590,256435,11041,10678,9510,6482,29071,29954,9331,9215,79695,2589,10418,9037,6480,6484,64409,1605,80070,9245,6483	GALNT4,ADAMTS10,GALNT2,ST6GALNAC3,B4GAT1,B3GNT2,ADAMTS1,ST3GAL1,C1GALT1C1,POMT2,B4GALT6,LARGE1,GALNT12,GALNT1,SPON1,SEMA5A,ST6GAL1,ST3GAL4,GALNT17,DAG1,ADAMTS20,GCNT3,ST3GAL2
R-HSA-5621480	Dectin-2 family	0.997590867177776	-0.00241203945194502	28	3	0.000929080210591514	3229	10285	2207,6850,93978	FCER1G,SYK,CLEC6A
R-HSA-194840	Rho GTPase cycle	0.997726878219118	-0.00227570924402013	142	30	0.00929080210591514	3229	10285	55843,5880,7074,90627,394,57381,9459,4952,221472,57584,6655,51306,5296,391,55789,7410,998,2665,392,1124,9886,399,9938,29127,388,94134,4983,84986,84904,58480	ARHGAP15,RAC2,TIAM1,STARD13,ARHGAP5,RHOJ,ARHGEF6,OCRL,FGD2,ARHGAP21,SOS2,FAM13B,PIK3R2,RHOG,DEPDC1B,VAV2,CDC42,GDI2,ARHGAP1,CHN2,RHOBTB1,RHOH,ARHGAP25,RACGAP1,RHOB,ARHGAP12,OPHN1,ARHGAP19,ARHGEF39,RHOU
R-HSA-1474228	Degradation of the extracellular matrix	0.997831509218614	-0.00217084536206094	111	22	0.00681325487767111	3229	10285	4323,824,6696,9313,440387,5654,5045,5340,1509,649,823,7076,5663,1508,85007,1215,5644,100126326,1513,9510,4318,23385	MMP14,CAPN2,SPP1,MMP20,CTRB2,HTRA1,FURIN,PLG,CTSD,BMP1,CAPN1,TIMP1,PSEN1,CTSB,PHYKPL,CMA1,PRSS1,MIR936,CTSK,ADAMTS1,MMP9,NCSTN
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	0.998097611808758	-0.00190420002990199	39	5	0.00154846701765252	3229	10285	81794,80070,9037,9510,10418	ADAMTS10,ADAMTS20,SEMA5A,ADAMTS1,SPON1
R-HSA-2672351	Stimuli-sensing channels	0.998195779444522	-0.00180585012174391	104	20	0.0061938680706101	3229	10285	6233,7311,1185,7314,5894,2281,6717,11059,57578,7220,2040,28962,41,57192,1831,40,1193,1179,63982,161003	RPS27A,UBA52,CLCN6,UBB,RAF1,FKBP1B,SRI,WWP1,UNC79,TRPC1,STOM,OSTM1,ASIC1,MCOLN1,TSC22D3,ASIC2,CLIC2,CLCA1,ANO3,STOML3
R-HSA-196807	Nicotinate metabolism	0.998236554806617	-0.00176500189323091	29	3	0.000929080210591514	3229	10285	83594,54981,952	NUDT12,NMRK1,CD38
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.998236554806617	-0.00176500189323091	29	3	0.000929080210591514	3229	10285	5465,6604,1387	PPARA,SMARCD3,CREBBP
R-HSA-6809371	Formation of the cornified envelope	0.998245689984028	-0.00175585061984949	71	12	0.00371632084236606	3229	10285	3728,5266,1475,5652,643394,5045,1041,6699,823,25818,4014,8502	JUP,PI3,CSTA,PRSS8,SPINK9,FURIN,CDSN,SPRR1B,CAPN1,KLK5,LORICRIN,PKP4
R-HSA-983712	Ion channel transport	0.998455543459018	-0.00154565044343102	209	47	0.0145555899659337	3229	10285	2561,528,2566,7220,57578,483,5894,2743,7314,8992,7311,161003,9550,57192,5350,90423,41,2741,478,2742,11059,53826,477,534,1185,481,63982,1179,818,1193,28962,533,27032,6717,2281,10396,476,2554,6233,493,2562,523,2555,40,1831,2040,51382	GABRB2,ATP6V1C1,GABRG2,TRPC1,UNC79,ATP1B3,RAF1,GLRB,UBB,ATP6V0E1,UBA52,STOML3,ATP6V1G1,MCOLN1,PLN,ATP6V1E2,ASIC1,GLRA1,ATP1A3,GLRA2,WWP1,FXYD6,ATP1A2,ATP6V1G2,CLCN6,ATP1B1,ANO3,CLCA1,CAMK2G,CLIC2,OSTM1,ATP6V0B,ATP2C1,SRI,FKBP1B,ATP8A1,ATP1A1,GABRA1,RPS27A,ATP2B4,GABRB3,ATP6V1A,GABRA2,ASIC2,TSC22D3,STOM,ATP6V1D
R-HSA-379724	tRNA Aminoacylation	0.998614631731304	-0.00138632877852499	45	6	0.00185816042118303	3229	10285	833,9521,5917,4141,2193,3735	CARS1,EEF1E1,RARS1,MARS1,FARSA,KARS1
R-HSA-3781865	Diseases of glycosylation	0.998667478671292	-0.00133340992472385	85	15	0.00464540105295757	3229	10285	81794,6385,2817,4853,5549,4060,6383,2239,2331,4969,9510,1605,80070,9037,10418	ADAMTS10,SDC4,GPC1,NOTCH2,PRELP,LUM,SDC2,GPC4,FMOD,OGN,ADAMTS1,DAG1,ADAMTS20,SEMA5A,SPON1
R-HSA-197264	Nicotinamide salvaging	0.998874316481751	-0.00112631757581762	18	1	0.000309693403530505	3229	10285	83594	NUDT12
R-HSA-1369062	ABC transporters in lipid homeostasis	0.998874316481751	-0.00112631757581762	18	1	0.000309693403530505	3229	10285	8504	PEX3
R-HSA-3214841	PKMTs methylate histone lysines	0.99887566627774	-0.00112496625958566	73	12	0.00371632084236606	3229	10285	2146,5928,84661,80854,84193,4790,8726,64754,8350,5931,51111,6839	EZH2,RBBP4,DPY30,SETD7,SETD3,NFKB1,EED,SMYD3,H3C1,RBBP7,KMT5B,SUV39H1
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.998945054094198	-0.00105550275289778	60	9	0.00278724063177454	3229	10285	1508,100313843,3655,1281,977,1278,9313,4318,649	CTSB,MIR711,ITGA6,COL3A1,CD151,COL1A2,MMP20,MMP9,BMP1
R-HSA-3295583	TRP channels	0.99900172233406	-0.000998776276951535	25	2	0.00061938680706101	3229	10285	57192,7220	MCOLN1,TRPC1
R-HSA-193648	NRAGE signals death through JNK	0.999673906914606	-0.000326146265305842	60	8	0.00247754722824404	3229	10285	6655,9459,572,26574,221472,7074,7410,84904	SOS2,ARHGEF6,BAD,AATF,FGD2,TIAM1,VAV2,ARHGEF39
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	0.999723593079673	-0.000276445127760245	70	10	0.00309693403530505	3229	10285	100126326,100313843,5479,871,64175,1281,8974,1278,10491,649	MIR936,MIR711,PPIB,SERPINH1,P3H1,COL3A1,P4HA2,COL1A2,CRTAP,BMP1
R-HSA-1474290	Collagen formation	0.999763575502653	-0.000236452450024393	93	15	0.00464540105295757	3229	10285	1508,100313843,3655,5479,1281,8974,9313,10491,100126326,871,64175,977,1278,4318,649	CTSB,MIR711,ITGA6,PPIB,COL3A1,P4HA2,MMP20,CRTAP,MIR936,SERPINH1,P3H1,CD151,COL1A2,MMP9,BMP1
R-HSA-379726	Mitochondrial tRNA aminoacylation	0.999829685887695	-0.000170328617400334	23	1	0.000309693403530505	3229	10285	3735	KARS1
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	0.999885158105035	-0.000114848489799936	59	7	0.00216785382471353	3229	10285	1605,10418,9510,9037,4853,81794,80070	DAG1,SPON1,ADAMTS1,SEMA5A,NOTCH2,ADAMTS10,ADAMTS20
R-HSA-3214842	HDMs demethylate histones	0.999957267109932	-4.27338031437887e-05	52	5	0.00154846701765252	3229	10285	23028,22992,84864,23030,8350	KDM1A,KDM2A,RIOX2,KDM4B,H3C1
R-HSA-8948216	Collagen chain trimerization	0.999964419711736	-3.55809212578984e-05	47	4	0.00123877361412202	3229	10285	1281,1278,100126326,100313843	COL3A1,COL1A2,MIR936,MIR711
R-HSA-212436	Generic Transcription Pathway	0.999982066886975	-1.79332738247779e-05	865	219	0.0678228553731806	3229	10285	1327,143686,51755,83667,8738,29883,902,116028,7421,7529,4193,5982,5931,169270,5876,7311,6881,6879,6827,5436,4088,84246,6873,7534,2033,57343,90809,7376,162239,1024,10000,1351,3815,28956,79837,29079,2968,6882,146542,2071,6749,11073,4848,144348,6233,367,5932,2063,1349,2100,355,7157,7323,672,1345,7329,7422,64769,5564,5325,1020,51204,7001,6118,4087,5366,57472,3329,2810,3725,7295,55634,80010,2353,5468,90390,1027,58500,54989,2966,6794,51241,388536,6921,6604,9442,3486,26523,6096,5928,5438,57336,4605,283337,7101,8856,9970,3622,55004,94115,4609,7586,891,1353,9439,1026,2539,79047,890,7029,53615,5111,619279,84289,5983,7321,5985,8550,1874,9377,133383,7296,3726,5728,332,9540,1647,8445,7728,5052,79027,9656,6917,7533,57690,57060,581,2963,84987,116228,6258,4343,4331,10308,5371,5431,124446,25888,207,7341,604,5516,60436,4929,5432,10419,27166,4089,79759,5571,28984,1387,4435,1025,8649,5608,404672,246175,7913,6880,4683,9219,190,5810,80196,6009,9440,7752,54541,4853,1460,2877,80818,5441,3516,5433,7832,5518,4697,7314,1340,5435,1022,983,2962,7743,10670,55657,7532,10127,208,665,9099,8851,79175,10325,5984,1457,94241,79891,29982,6667,9337,51003,6829,221785,5465,5241,6119	COX4I1,SESN3,CDK12,SESN2,CRADD,CNOT7,CCNH,RMI2,VDR,YWHAB,MDM2,RFC2,RBBP7,ZNF596,RABGGTB,UBA52,TAF10,TAF7,SUPT4H1,POLR2G,SMAD3,MED10,TAF2,YWHAZ,EP300,ZNF304,PIP4P1,NR1H2,ZFP1,CDK8,AKT3,COX8A,KIT,LAMTOR2,PIP4K2C,MED4,GTF2H4,TAF11,ZNF688,ERCC3,SSRP1,TOPBP1,CNOT2,ZNF664,RPS27A,AR,RBBP8,NR2F6,COX7B,ESR2,FAS,TP53,UBE2D3,BRCA1,COX6C,UBE2I,VEGFA,MEAF6,PRKAB1,PLAGL1,CDK5,TACO1,PRDX2,RPA2,SMAD2,PMAIP1,CNOT6,HSPD1,SFN,JUN,TXN,KRBOX4,RMI1,FOS,PPARG,MED30,CDKN1B,ZNF250,ZNF770,GTF2H2,STK11,COX16,ZNF790,ELOC,SMARCD3,MED27,IGFBP3,AGO1,RORB,RBBP4,POLR2I,ZNF287,MYBL2,ZNF740,NR2E1,NR1I2,NR1I3,ING2,LAMTOR1,CGB8,MYC,ZKSCAN1,CCNB1,COX11,MED23,CDKN1A,G6PD,KCTD15,CCNA2,TFDP2,MBD3,PCNA,ZNF704,ING5,RFC3,UBE2D1,RFC5,MAPKAPK5,E2F4,COX5A,SETD9,TXNRD1,JUNB,PTEN,BIRC5,TP53I3,GADD45A,DYRK2,ZNF175,PRDX1,ZNF655,MDC1,TCEA1,YWHAH,TNRC6C,PCBP4,BAX,GTF2F2,COX14,COX20,RXRG,MOV10,MNAT1,ZNF267,PML,POLR2B,TMEM219,ZNF473,AKT1,SUMO1,BCL6,PPP2CB,TGIF2,NR4A2,POLR2C,PRMT5,PRELID1,SMAD4,ZNF668,PRKAG1,RGCC,CREBBP,CITED1,CDK9,LAMTOR3,MAP2K6,GTF2H5,CNOT6L,DEK,TAF9,NBN,MTA2,NR0B1,RAD1,RNF34,RHEB,MED17,ZNF200,DDIT4,NOTCH2,CSNK2B,GPX2,ZNF436,POLR2L,RBPJ,POLR2D,BTG2,PPP2R1A,NDUFA4,UBB,COX6B1,POLR2F,CDK7,CDK1,GTF2F1,ZNF189,RRAGA,ZNF692,YWHAG,ZNF263,AKT2,BNIP3L,USP2,CDK5R1,ZNF343,RRAGB,RFC4,CSNK2A1,TP53INP1,ZNF671,NRBF2,SP1,CNOT8,MED31,SUPT5H,ZSCAN25,PPARA,PGR,RPA3
R-HSA-1474244	Extracellular matrix organization	0.999994874264164	-5.125748972434e-06	296	60	0.0185816042118303	3229	10285	4060,6383,50848,2331,23385,4318,6385,1215,100126326,5578,85007,51399,7042,1281,7076,5663,1508,3655,3913,5340,7276,8785,871,440387,4236,6696,7143,4323,780,1605,100313843,3696,9510,3693,5644,64175,1513,3685,3673,10491,961,8573,649,1509,3384,977,1278,823,5654,5045,10516,8174,3383,824,9313,8974,7043,3385,5479,59277	LUM,SDC2,F11R,FMOD,NCSTN,MMP9,SDC4,CMA1,MIR936,PRKCA,PHYKPL,TRAPPC4,TGFB2,COL3A1,TIMP1,PSEN1,CTSB,ITGA6,LAMB2,PLG,TTR,MATN4,SERPINH1,CTRB2,MFAP1,SPP1,TNR,MMP14,DDR1,DAG1,MIR711,ITGB8,ADAMTS1,ITGB5,PRSS1,P3H1,CTSK,ITGAV,ITGA2,CRTAP,CD47,CASK,BMP1,CTSD,ICAM2,CD151,COL1A2,CAPN1,HTRA1,FURIN,FBLN5,MADCAM1,ICAM1,CAPN2,MMP20,P4HA2,TGFB3,ICAM3,PPIB,NTN4
R-HSA-381753	Olfactory Signaling Pathway	0.999999956029881	-4.39701195864037e-08	391	77	0.0238463920718489	3229	10285	219875,79290,390260,119692,121130,64108,442361,10798,441639,390265,219870,392138,124538,341418,219986,125963,219431,120586,81285,121364,221035,2782,390152,26211,441608,219858,442191,219865,390433,219959,390431,390093,120775,26686,338675,341152,283694,390261,26339,125958,138802,119765,401666,134083,219960,390157,441670,79544,26534,219954,390199,120787,390436,390437,26648,119772,390059,26533,390162,92840,26692,283162,403253,390195,219437,219983,219981,81696,26493,7932,4992,80346,442186,390429,283297,441669,390648	OR4D5,OR13A1,OR6X1,OR51S1,OR10P1,RTP4,OR2A2,OR5I1,OR9K2,OR10G7,OR10G9,OR2A25,OR4D2,OR6C4,OR4D11,OR1M1,OR4S2,OR8I2,OR51E2,OR10A7,REEP3,GNB1,OR8H3,OR2F1,OR5B3,OR8B12,OR14J1,OR8G5,OR4K13,OR1S1,OR4K2,OR10A6,OR2D3,OR4E2,OR5AP2,OR2AT4,OR4N4,OR6M1,OR5K1,OR7D4,OR13C8,OR4B1,OR51A4,OR2Y1,OR10Q1,OR8K1,OR4M1,OR4K1,OR10G2,OR9I1,OR4D9,OR52W1,OR4K17,OR4N5,OR7E24,OR52M1,OR51M1,OR10G3,OR5M9,REEP6,OR2W1,OR8B4,OR4A47,OR5AN1,OR5L1,OR4D6,OR5A2,OR5V1,OR8B8,OR2H2,OR1F1,REEP4,OR2J3,OR4N2,OR10A4,OR4Q3,OR4F6
R-HSA-6805567	Keratinization	0.999999999925746	-7.42544688336537e-11	214	18	0.00557448126354909	3229	10285	1475,5266,3728,643394,5652,85285,3856,3855,25818,823,6699,4014,337879,8502,5045,83896,386684,1041	CSTA,PI3,JUP,SPINK9,PRSS8,KRTAP4-1,KRT8,KRT7,KLK5,CAPN1,SPRR1B,LORICRIN,KRTAP8-1,PKP4,FURIN,KRTAP3-1,KRTAP12-4,CDSN
R-HSA-444257	RSK activation	0.999999999967997	-3.20025307252655e-11	6	0	0	3229	10285
R-HSA-428808	Na+-dependent glucose transporters	0.999999999967997	-3.20025307252655e-11	6	0	0	3229	10285
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	0.999999999967997	-3.20025307252655e-11	6	0	0	3229	10285
R-HSA-1566977	Fibronectin matrix formation	0.999999999967997	-3.20025307252655e-11	6	0	0	3229	10285
R-HSA-140180	COX reactions	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-975574	Reactions specific to the hybrid N-glycan synthesis pathway	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1839128	FGFR4 mutant receptor activation	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-168330	Viral RNP Complexes in the Host Cell Nucleus	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-2033515	t(4;14) translocations of FGFR3	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-163316	Mitochondrial transcription termination	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1855231	Synthesis of IPs in the ER lumen	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-2023837	Signaling by FGFR2 amplification mutants	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1222449	Mtb iron assimilation by chelation	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-2466712	Biosynthesis of A2E, implicated in retinal degradation	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1300645	Acrosome Reaction	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1222352	Latent infection of Homo sapiens with Mycobacterium tuberculosis	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-3359457	Defective GIF causes intrinsic factor deficiency	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-2142696	Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-8853333	Signaling by FGFR2 fusions	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-3359454	Defective TCN2 causes hereditary megaloblastic anemia	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-2534343	Interaction With Cumulus Cells	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1299344	TWIK-related spinal cord K+ channel (TRESK)	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-5340573	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1483076	Synthesis of CL	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-211957	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-1222499	Response of Mtb to phagocytosis	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-6809583	Retinoid metabolism disease events	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-3248023	Regulation by TREX1	0.999999999984929	-1.50712775592865e-11	1	0	0	3229	10285
R-HSA-916853	Degradation of GABA	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-177162	Conjugation of phenylacetate with glutamine	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-3359485	Defective CD320 causes methylmalonic aciduria	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-70688	Proline catabolism	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-1614603	Cysteine formation from homocysteine	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-187042	TRKA activation by NGF	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-380612	Metabolism of serotonin	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-844623	The IPAF inflammasome	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-8849175	Threonine catabolism	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-8942233	Intestinal infectious diseases	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-3858516	Glycogen storage disease type 0 (liver GYS2)	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-168277	Influenza Virus Induced Apoptosis	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-111995	phospho-PLA2 pathway	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-71737	Pyrophosphate hydrolysis	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-5357609	Glycogen storage disease type II (GAA)	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-211994	Sterols are 12-hydroxylated by CYP8B1	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-111457	Release of apoptotic factors from the mitochondria	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-198765	Signalling to ERK5	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-5619107	Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC)	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-5579031	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-205017	NFG and proNGF binds to p75NTR	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-77042	Formation of editosomes by ADAR proteins	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-5602636	IKBKB deficiency causes SCID	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-428559	Proton-coupled neutral amino acid transporters	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-3359469	Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-141333	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-1299316	TWIK-releated acid-sensitive K+ channel (TASK)	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-8854521	Interaction between PHLDA1 and AURKA	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-75102	C6 deamination of adenosine	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-75064	mRNA Editing: A to I Conversion	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-1483152	Hydrolysis of LPE	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-68881	Mitotic Metaphase/Anaphase Transition	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-3359467	Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	0.999999999986743	-1.32573396705027e-11	2	0	0	3229	10285
R-HSA-376172	DSCAM interactions	0.999999999992104	-7.89562172636427e-12	11	0	0	3229	10285
R-HSA-111464	SMAC-mediated dissociation of IAP:caspase complexes	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-8849468	PTK6 Regulates Proteins Involved in RNA Processing	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-5662702	Melanin biosynthesis	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-444209	Free fatty acid receptors	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-111463	SMAC binds to IAPs	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-111461	Cytochrome c-mediated apoptotic response	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-1306955	GRB7 events in ERBB2 signaling	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-70350	Fructose catabolism	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-111469	SMAC-mediated apoptotic response	0.999999999993495	-6.50479930336401e-12	5	0	0	3229	10285
R-HSA-75944	Transcription from mitochondrial promoters	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-442745	Activation of CaMK IV	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-428542	Regulation of Commissural axon pathfinding by Slit and Robo	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-1369007	Mitochondrial ABC transporters	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-1251932	PLCG1 events in ERBB2 signaling	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-8866906	TFAP2 (AP-2) family regulates transcription of other transcription factors	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-2473224	Antagonism of Activin by Follistatin	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-1296061	HCN channels	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-209563	Axonal growth stimulation	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-3000497	Scavenging by Class H Receptors	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-6803544	Ion influx/efflux at host-pathogen interface	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-8935690	Miscellaneous digestion events	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-5579026	Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-428776	Class II GLUTs	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-173736	Alternative complement activation	0.999999999997074	-2.92575165483644e-12	4	0	0	3229	10285
R-HSA-1234162	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-111458	Formation of apoptosome	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-3359462	Defective AMN causes hereditary megaloblastic anemia 1	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-163282	Mitochondrial transcription initiation	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-427589	Type II Na+/Pi cotransporters	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-392023	Adrenaline signalling through Alpha-2 adrenergic receptor	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-3359463	Defective CUBN causes hereditary megaloblastic anemia 1	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-198745	Signalling to STAT3	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-5357572	Lysosomal glycogen catabolism	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-5688031	Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-880009	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-5658034	HHAT G278V abrogates palmitoylation of Hh-Np	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-2395516	Electron transport from NADPH to Ferredoxin	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-977442	GABA A (rho) receptor activation	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-139910	Activation of BMF and translocation to mitochondria	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-1307965	betaKlotho-mediated ligand binding	0.999999999999652	-3.4765246237356e-13	3	0	0	3229	10285
R-HSA-5576890	Phase 3 - rapid repolarisation	0.999999999999694	-3.06406918067215e-13	8	0	0	3229	10285
R-HSA-196783	Coenzyme A biosynthesis	0.999999999999694	-3.06406918067215e-13	8	0	0	3229	10285
R-HSA-5362798	Release of Hh-Np from the secreting cell	0.999999999999694	-3.06406918067215e-13	8	0	0	3229	10285
R-HSA-1482883	Acyl chain remodeling of DAG and TAG	0.999999999999694	-3.06406918067215e-13	8	0	0	3229	10285
R-HSA-425986	Sodium/Proton exchangers	1.00000000000767	7.67351694610108e-12	9	0	0	3229	10285
R-HSA-419771	Opsins	1.00000000000767	7.67351694610108e-12	9	0	0	3229	10285
R-HSA-1300642	Sperm Motility And Taxes	1.00000000000767	7.67351694610108e-12	9	0	0	3229	10285
R-HSA-3595172	Defective CHST3 causes SEDCJD	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-174577	Activation of C3 and C5	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-111471	Apoptotic factor-mediated response	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-3595174	Defective CHST14 causes EDS, musculocontractural type	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-2660826	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-2660825	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-429593	Inositol transporters	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-3595177	Defective CHSY1 causes TPBS	1.00000000000947	9.4701823965225e-12	7	0	0	3229	10285
R-HSA-427601	Multifunctional anion exchangers	1.00000000000951	9.51409299108398e-12	10	0	0	3229	10285
R-HSA-1663150	The activation of arylsulfatases	1.00000000001819	1.81948518476243e-11	13	0	0	3229	10285
R-HSA-192456	Digestion of dietary lipid	1.00000000002158	2.15765100100716e-11	17	0	0	3229	10285
R-HSA-5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	1.00000000002158	2.15765100100716e-11	17	0	0	3229	10285
R-HSA-5083625	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	1.00000000002158	2.15765100100716e-11	17	0	0	3229	10285
R-HSA-5083636	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	1.00000000002158	2.15765100100716e-11	17	0	0	3229	10285