TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
ko03010	Ribosome	1.47819929448507e-11	-24.9376113688457	134	84	0.0341047503045067	2463	7161	64979,6133,65003,6141,6181,6201,6193,79590,6224,9349,11224,140801,65005,6159,6204,6165,6229,6128,6235,51121,6209,55052,6154,6143,6203,54948,6160,6191,6139,6218,6207,4736,6122,6168,6187,6147,6157,6134,6132,6129,6228,6208,6176,6217,9553,63875,64965,51081,6124,55168,6188,6136,6158,6175,23521,51023,28998,3921,7311,51065,64981,29093,64963,6233,6150,6152,6155,124995,6206,51373,6182,6234,51021,6205,6138,6146,54460,51187,6170,29074,2197,6161,6231,6130	MRPL36,RPL9,MRPL11,RPL18,RPLP2,RPS7,RPS5,MRPL24,RPS20,RPL23,RPL35,RPL10L,MRPL9,RPL29,RPS10,RPL35A,RPS24,RPL6,RPS29,RPL26L1,RPS15,MRPL20,RPL26,RPL19,RPS9,MRPL16,RPL31,RPS4X,RPL17,RPS17,RPS13,RPL10A,RPL3,RPL37A,RPS2,RPL23A,RPL27A,RPL10,RPL8,RPL7,RPS23,RPS14,RPLP1,RPS16,MRPL33,MRPL17,MRPS9,MRPS7,RPL4,MRPS18A,RPS3,RPL12,RPL28,RPLP0,RPL13A,MRPS18C,MRPL13,RPSA,UBA52,RPS27L,MRPL34,MRPL22,MRPS11,RPS27A,MRPL23,RPL24,RPL27,MRPL10,RPS12,MRPS17,MRPL12,RPS28,MRPS16,RPS11,RPL15,RPL22,MRPS21,RSL24D1,RPL39,MRPL18,FAU,RPL32,RPS26,RPL7A
hsa03010	Ribosome	1.47819929448507e-11	-24.9376113688457	134	84	0.0341047503045067	2463	7161	6122,4736,6139,6218,6207,6134,6157,6187,6147,6168,6143,6191,54948,6160,6203,6165,6204,140801,65005,6159,11224,9349,6224,6154,55052,6209,51121,6235,6229,6128,6181,6141,65003,6133,64979,79590,6193,6201,6161,2197,29074,6170,54460,51187,6130,6231,6234,6182,51373,6155,6206,124995,6152,6146,6138,6205,51021,64963,29093,64981,51065,3921,7311,28998,6150,6233,51081,63875,64965,9553,6217,6208,6176,6228,6129,6132,51023,23521,6158,6175,6136,55168,6124,6188	RPL3,RPL10A,RPL17,RPS17,RPS13,RPL10,RPL27A,RPS2,RPL23A,RPL37A,RPL19,RPS4X,MRPL16,RPL31,RPS9,RPL35A,RPS10,RPL10L,MRPL9,RPL29,RPL35,RPL23,RPS20,RPL26,MRPL20,RPS15,RPL26L1,RPS29,RPS24,RPL6,RPLP2,RPL18,MRPL11,RPL9,MRPL36,MRPL24,RPS5,RPS7,RPL32,FAU,MRPL18,RPL39,MRPS21,RSL24D1,RPL7A,RPS26,RPS28,MRPL12,MRPS17,RPL27,RPS12,MRPL10,RPL24,RPL22,RPL15,RPS11,MRPS16,MRPS11,MRPL22,MRPL34,RPS27L,RPSA,UBA52,MRPL13,MRPL23,RPS27A,MRPS7,MRPL17,MRPS9,MRPL33,RPS16,RPS14,RPLP1,RPS23,RPL7,RPL8,MRPS18C,RPL13A,RPL28,RPLP0,RPL12,MRPS18A,RPL4,RPS3
M00177	Ribosome, eukaryotes	1.74489593906006e-10	-22.4691560098407	91	61	0.024766544863987	2463	7161	6193,6201,6141,6181,6133,6209,6154,51121,6229,6128,6235,6159,140801,6165,6204,6224,11224,9349,6191,6160,6203,6143,6157,6134,6147,6187,6168,6139,6218,6207,4736,6122,6158,6175,23521,6188,6124,6136,6208,6217,6176,6132,6228,6129,6233,51065,7311,3921,6138,6146,6205,6234,6152,6155,6206,6130,6231,6161,2197,51187,6170	RPS5,RPS7,RPL18,RPLP2,RPL9,RPS15,RPL26,RPL26L1,RPS24,RPL6,RPS29,RPL29,RPL10L,RPL35A,RPS10,RPS20,RPL35,RPL23,RPS4X,RPL31,RPS9,RPL19,RPL27A,RPL10,RPL23A,RPS2,RPL37A,RPL17,RPS17,RPS13,RPL10A,RPL3,RPL28,RPLP0,RPL13A,RPS3,RPL4,RPL12,RPS14,RPS16,RPLP1,RPL8,RPS23,RPL7,RPS27A,RPS27L,UBA52,RPSA,RPL15,RPL22,RPS11,RPS28,RPL24,RPL27,RPS12,RPL7A,RPS26,RPL32,FAU,RSL24D1,RPL39
hsa_M00177	Ribosome, eukaryotes	1.74489593906006e-10	-22.4691560098407	91	61	0.024766544863987	2463	7161	6206,6155,6152,6234,6205,6146,6138,6170,51187,2197,6161,6231,6130,6129,6228,6132,6208,6176,6217,6136,6124,6188,23521,6158,6175,7311,3921,51065,6233,6143,6203,6160,6191,4736,6122,6218,6139,6207,6168,6147,6187,6134,6157,6133,6181,6141,6201,6193,9349,11224,6224,6204,6165,140801,6159,6229,6128,6235,51121,6154,6209	RPS12,RPL27,RPL24,RPS28,RPS11,RPL22,RPL15,RPL39,RSL24D1,FAU,RPL32,RPS26,RPL7A,RPL7,RPS23,RPL8,RPS14,RPLP1,RPS16,RPL12,RPL4,RPS3,RPL13A,RPL28,RPLP0,UBA52,RPSA,RPS27L,RPS27A,RPL19,RPS9,RPL31,RPS4X,RPL10A,RPL3,RPS17,RPL17,RPS13,RPL37A,RPL23A,RPS2,RPL10,RPL27A,RPL9,RPLP2,RPL18,RPS7,RPS5,RPL23,RPL35,RPS20,RPS10,RPL35A,RPL10L,RPL29,RPS24,RPL6,RPS29,RPL26L1,RPL26,RPS15
hsa05162	Measles	1.9232867006788e-08	-17.766645198142	133	77	0.0312626877791311	2463	7161	5296,51135,51284,207,3559,3717,3565,5295,10379,4938,356,7099,3454,595,4793,3459,3593,51209,9367,23586,29110,4599,1965,4179,6776,1019,6772,208,3447,3553,940,896,5290,3312,3665,3560,7097,8503,23118,7157,3458,1021,57506,3716,3440,5588,917,2213,3596,3661,4792,3592,3558,5610,4615,3456,10000,8743,355,3561,4790,4478,3446,7128,1457,25898,64135,7189,6773,3569,3552,6869,1027,4068,1460,30835,54106	PIK3R2,IRAK4,TLR7,AKT1,IL2RA,JAK2,IL4,PIK3R1,IRF9,OAS1,FASLG,TLR4,IFNAR1,CCND1,NFKBIB,IFNGR1,IL12B,RAB9B,RAB9A,RIGI,TBK1,MX1,EIF2S1,CD46,STAT5A,CDK4,STAT1,AKT2,IFNA13,IL1B,CD28,CCND3,PIK3CA,HSPA8,IRF7,IL2RB,TLR2,PIK3R3,TAB2,TP53,IFNG,CDK6,MAVS,JAK1,IFNA2,PRKCQ,CD3G,FCGR2B,IL13,IRF3,NFKBIA,IL12A,IL2,EIF2AK2,MYD88,IFNB1,AKT3,TNFSF10,FAS,IL2RG,NFKB1,MSN,IFNA10,TNFAIP3,CSNK2A1,RCHY1,IFIH1,TRAF6,STAT2,IL6,IL1A,TACR1,CDKN1B,SH2D1A,CSNK2B,CD209,TLR9
ko05162	Measles	1.9232867006788e-08	-17.766645198142	133	77	0.0312626877791311	2463	7161	3447,3553,940,896,3312,5290,3665,3560,7097,8503,23118,9367,23586,29110,4599,1965,4179,6776,1019,6772,208,356,7099,3454,595,4793,3459,3593,51209,5296,51284,51135,207,3559,3565,3717,5295,10379,4938,3569,3552,6869,1027,4068,30835,1460,54106,4615,3456,10000,8743,355,3561,4478,4790,3446,7128,1457,25898,64135,6773,7189,3716,3440,5588,2213,917,3596,3661,4792,3592,3558,5610,7157,3458,1021,57506	IFNA13,IL1B,CD28,CCND3,HSPA8,PIK3CA,IRF7,IL2RB,TLR2,PIK3R3,TAB2,RAB9A,RIGI,TBK1,MX1,EIF2S1,CD46,STAT5A,CDK4,STAT1,AKT2,FASLG,TLR4,IFNAR1,CCND1,NFKBIB,IFNGR1,IL12B,RAB9B,PIK3R2,TLR7,IRAK4,AKT1,IL2RA,IL4,JAK2,PIK3R1,IRF9,OAS1,IL6,IL1A,TACR1,CDKN1B,SH2D1A,CD209,CSNK2B,TLR9,MYD88,IFNB1,AKT3,TNFSF10,FAS,IL2RG,MSN,NFKB1,IFNA10,TNFAIP3,CSNK2A1,RCHY1,IFIH1,STAT2,TRAF6,JAK1,IFNA2,PRKCQ,FCGR2B,CD3G,IL13,IRF3,NFKBIA,IL12A,IL2,EIF2AK2,TP53,IFNG,CDK6,MAVS
ko03050	Proteasome	1.02880248871995e-07	-16.0897001574088	45	33	0.0133982947624848	2463	7161	5707,5718,7979,5684,122706,5689,5693,5692,51371,5695,5710,11047,5702,5705,5720,5699,5700,5687,5704,5713,5690,5709,5694,5691,5686,5683,5682,5685,3458,5698,10213,5721,9861	PSMD1,PSMD12,SEM1,PSMA3,PSMB11,PSMB1,PSMB5,PSMB4,POMP,PSMB7,PSMD4,ADRM1,PSMC3,PSMC5,PSME1,PSMB10,PSMC1,PSMA6,PSMC4,PSMD7,PSMB2,PSMD3,PSMB6,PSMB3,PSMA5,PSMA2,PSMA1,PSMA4,IFNG,PSMB9,PSMD14,PSME2,PSMD6
hsa03050	Proteasome	1.02880248871995e-07	-16.0897001574088	45	33	0.0133982947624848	2463	7161	3458,5685,5683,5682,9861,5721,10213,5698,5686,5691,5713,5694,5690,5709,5720,5704,5687,5699,5700,5705,5702,5695,51371,5692,5693,11047,5710,122706,5689,5684,7979,5707,5718	IFNG,PSMA4,PSMA2,PSMA1,PSMD6,PSME2,PSMD14,PSMB9,PSMA5,PSMB3,PSMD7,PSMB6,PSMB2,PSMD3,PSME1,PSMC4,PSMA6,PSMB10,PSMC1,PSMC5,PSMC3,PSMB7,POMP,PSMB4,PSMB5,ADRM1,PSMD4,PSMB11,PSMB1,PSMA3,SEM1,PSMD1,PSMD12
hsa04620	Toll-like receptor signaling pathway	1.07141379575929e-07	-16.0491165701911	104	62	0.0251725537961835	2463	7161	958,54106,10454,3569,7100,6352,7189,5604,7096,3446,4790,54472,10000,4283,3456,4615,3592,4792,3661,114609,388372,3576,3440,7098,1513,2353,6348,3627,941,353376,5608,23118,8503,7097,3665,5290,7124,942,3553,3447,208,3725,6772,148022,29110,3593,5606,3454,7099,10333,5602,51311,3551,6696,929,23643,5295,207,51135,51284,5296,6373	CD40,TLR9,TAB1,IL6,TLR5,CCL5,TRAF6,MAP2K1,TLR1,IFNA10,NFKB1,TOLLIP,AKT3,CXCL9,IFNB1,MYD88,IL12A,NFKBIA,IRF3,TIRAP,CCL4L1,CXCL8,IFNA2,TLR3,CTSK,FOS,CCL3,CXCL10,CD80,TICAM2,MAP2K6,TAB2,PIK3R3,TLR2,IRF7,PIK3CA,TNF,CD86,IL1B,IFNA13,AKT2,JUN,STAT1,TICAM1,TBK1,IL12B,MAP2K3,IFNAR1,TLR4,TLR6,MAPK10,TLR8,IKBKB,SPP1,CD14,LY96,PIK3R1,AKT1,IRAK4,TLR7,PIK3R2,CXCL11
ko04620	Toll-like receptor signaling pathway	1.07141379575929e-07	-16.0491165701911	104	62	0.0251725537961835	2463	7161	6373,5296,207,51135,51284,23643,5295,929,5602,51311,6696,3551,3454,7099,10333,5606,3593,29110,148022,208,3725,6772,3553,3447,5290,7124,942,3665,5608,23118,8503,7097,941,353376,6348,3627,2353,7098,1513,3440,388372,3576,4792,3661,114609,3592,10000,3456,4283,4615,3446,4790,54472,7096,6352,7189,5604,3569,7100,10454,54106,958	CXCL11,PIK3R2,AKT1,IRAK4,TLR7,LY96,PIK3R1,CD14,MAPK10,TLR8,SPP1,IKBKB,IFNAR1,TLR4,TLR6,MAP2K3,IL12B,TBK1,TICAM1,AKT2,JUN,STAT1,IL1B,IFNA13,PIK3CA,TNF,CD86,IRF7,MAP2K6,TAB2,PIK3R3,TLR2,CD80,TICAM2,CCL3,CXCL10,FOS,TLR3,CTSK,IFNA2,CCL4L1,CXCL8,NFKBIA,IRF3,TIRAP,IL12A,AKT3,IFNB1,CXCL9,MYD88,IFNA10,NFKB1,TOLLIP,TLR1,CCL5,TRAF6,MAP2K1,IL6,TLR5,TAB1,TLR9,CD40
hsa04062	Chemokine signaling pathway	4.46943681435953e-07	-14.6208332425838	182	95	0.0385708485586683	2463	7161	2790,8976,2833,10235,5908,6370,6361,6356,7852,2785,2268,6352,1232,388372,5567,2931,1236,3265,6714,4792,6363,9475,51764,5906,59345,2919,3627,6368,6093,6347,6655,2787,8503,2921,3702,2771,1233,1399,729230,6366,3551,2784,4793,6362,3717,5330,1524,207,3577,5296,2773,56477,10563,55970,4790,6364,2782,10000,4283,6346,9844,6369,108,6355,6773,5604,1230,5894,1235,3576,6348,109,2788,53358,6376,5290,6387,5880,5579,208,6772,2791,54331,1234,7074,6464,7410,23236,998,6373,3845,10663,2793,10850,5295	GNG10,WASL,CXCR3,RASGRP2,RAP1B,CCL25,CCL17,CCL11,CXCR4,GNG3,FGR,CCL5,CCR3,CCL4L1,PRKACB,GSK3A,CCR7,HRAS,SRC,NFKBIA,CCL19,ROCK2,GNG13,RAP1A,GNB4,CXCL1,CXCL10,CCL23,ROCK1,CCL2,SOS2,GNG5,PIK3R3,CXCL3,ITK,GNAI2,CCR4,CRKL,CCR2,CCL21,IKBKB,GNB3,NFKBIB,CCL18,JAK2,PLCB2,CX3CR1,AKT1,CXCR1,PIK3R2,GNAI3,CCL28,CXCL13,GNG12,NFKB1,CCL20,GNB1,AKT3,CXCL9,CCL1,ELMO1,CCL24,ADCY2,CCL8,STAT2,MAP2K1,CCR1,RAF1,CCR6,CXCL8,CCL3,ADCY3,GNG7,SHC3,CX3CL1,PIK3CA,CXCL12,RAC2,PRKCB,AKT2,STAT1,GNG11,GNG2,CCR5,TIAM1,SHC1,VAV2,PLCB1,CDC42,CXCL11,KRAS,CXCR6,GNGT2,CCL27,PIK3R1
ko04062	Chemokine signaling pathway	4.46943681435953e-07	-14.6208332425838	182	95	0.0385708485586683	2463	7161	2919,59345,3627,1232,388372,5567,2931,1236,3265,6714,4792,6363,9475,51764,5906,7852,6356,2785,2268,6352,2790,2833,8976,10235,5908,6370,6361,3717,5330,1524,207,3577,5296,2773,1233,1399,729230,6366,3551,2784,4793,6362,2921,3702,2771,6368,6093,6347,6655,2787,8503,6348,109,2788,53358,6376,5894,3576,1235,4790,6364,2782,10000,4283,6346,6369,9844,108,6355,6773,5604,1230,56477,10563,55970,998,6373,3845,10663,2793,10850,5295,7074,7410,6464,23236,5579,208,6772,2791,54331,1234,6387,5290,5880	CXCL1,GNB4,CXCL10,CCR3,CCL4L1,PRKACB,GSK3A,CCR7,HRAS,SRC,NFKBIA,CCL19,ROCK2,GNG13,RAP1A,CXCR4,CCL11,GNG3,FGR,CCL5,GNG10,CXCR3,WASL,RASGRP2,RAP1B,CCL25,CCL17,JAK2,PLCB2,CX3CR1,AKT1,CXCR1,PIK3R2,GNAI3,CCR4,CRKL,CCR2,CCL21,IKBKB,GNB3,NFKBIB,CCL18,CXCL3,ITK,GNAI2,CCL23,ROCK1,CCL2,SOS2,GNG5,PIK3R3,CCL3,ADCY3,GNG7,SHC3,CX3CL1,RAF1,CXCL8,CCR6,NFKB1,CCL20,GNB1,AKT3,CXCL9,CCL1,CCL24,ELMO1,ADCY2,CCL8,STAT2,MAP2K1,CCR1,CCL28,CXCL13,GNG12,CDC42,CXCL11,KRAS,CXCR6,GNGT2,CCL27,PIK3R1,TIAM1,VAV2,SHC1,PLCB1,PRKCB,AKT2,STAT1,GNG11,GNG2,CCR5,CXCL12,PIK3CA,RAC2
hsa04130	SNARE interactions in vesicular transport	6.1345083683299e-07	-14.304165711568	34	26	0.0105562322371092	2463	7161	10228,10282,6804,10652,9554,55014,9342,6844,8417,8773,10791,55850,53407,9570,8673,8675,10490,6845,6843,8676,9482,6811,9341,51272,9527,8677	STX6,BET1,STX1A,YKT6,SEC22B,STX17,SNAP29,VAMP2,STX7,SNAP23,VAMP5,USE1,STX18,GOSR2,VAMP8,STX16,VTI1B,VAMP7,VAMP1,STX11,STX8,STX5,VAMP3,BET1L,GOSR1,STX10
ko04130	SNARE interactions in vesicular transport	6.1345083683299e-07	-14.304165711568	34	26	0.0105562322371092	2463	7161	10791,55850,53407,8417,8773,6844,55014,9342,10652,9554,10228,6804,10282,8677,9527,9341,51272,6811,9482,6843,8676,6845,8675,10490,8673,9570	VAMP5,USE1,STX18,STX7,SNAP23,VAMP2,STX17,SNAP29,YKT6,SEC22B,STX6,STX1A,BET1,STX10,GOSR1,VAMP3,BET1L,STX5,STX8,VAMP1,STX11,VAMP7,STX16,VTI1B,VAMP8,GOSR2
hsa05161	Hepatitis B	7.09259795136301e-07	-14.1590439527976	144	78	0.0316686967113276	2463	7161	5728,3845,5295,7043,4088,207,5296,6778,3454,4318,595,890,7099,5602,148327,1387,3551,356,3725,208,6772,1019,100506742,1959,148022,6776,5579,10488,1026,29110,23586,5111,7529,8503,7097,3665,5290,7124,572,581,3447,57506,7098,1385,2353,7042,1021,353376,7157,7534,2033,4089,6714,3265,3661,4792,114609,5925,332,3576,5894,468,3440,3716,2002,5604,6773,64135,4790,4609,3446,355,3456,10000,4615,5578,1027,3569	PTEN,KRAS,PIK3R1,TGFB3,SMAD3,AKT1,PIK3R2,STAT6,IFNAR1,MMP9,CCND1,CCNA2,TLR4,MAPK10,CREB3L4,CREBBP,IKBKB,FASLG,JUN,AKT2,STAT1,CDK4,CASP12,EGR2,TICAM1,STAT5A,PRKCB,CREB3,CDKN1A,TBK1,RIGI,PCNA,YWHAB,PIK3R3,TLR2,IRF7,PIK3CA,TNF,BAD,BAX,IFNA13,MAVS,TLR3,CREB1,FOS,TGFB2,CDK6,TICAM2,TP53,YWHAZ,EP300,SMAD4,SRC,HRAS,IRF3,NFKBIA,TIRAP,RB1,BIRC5,CXCL8,RAF1,ATF4,IFNA2,JAK1,ELK1,MAP2K1,STAT2,IFIH1,NFKB1,MYC,IFNA10,FAS,IFNB1,AKT3,MYD88,PRKCA,CDKN1B,IL6
ko03040	Spliceosome	3.12629906006833e-06	-12.675660661933	132	71	0.0288266341859521	2463	7161	23658,51362,27339,10084,988,10907,57819,6427,56259,10285,1655,57187,6635,6629,11325,9128,6632,23451,84321,83443,10713,6627,6432,6429,7919,3183,3312,9775,51503,6637,6628,6426,55110,9879,6434,51639,84991,8449,27258,8559,10929,51729,26121,9416,51691,25804,4116,10772,6633,6634,9410,6626,10465,9984,153527,3190,6625,9785,29896,1665,11157,6100,10189,10262,55696,22916,10569,3178,8896,10291,11017	LSM5,CDC40,PRPF19,PQBP1,CDC5L,TXNL4A,LSM2,SRSF2,CTNNBL1,SMNDC1,DDX5,THOC2,SNRPE,SNRPB2,DDX42,PRPF4,SNRPD1,SF3B1,THOC3,SF3B5,USP39,SNRPA1,SRSF7,SRSF4,DDX39B,HNRNPC,HSPA8,EIF4A3,CWC15,SNRPG,SNRPB,SRSF1,MAGOHB,DDX46,TRA2B,SF3B6,RBM17,DHX16,LSM3,PRPF18,SRSF8,WBP11,PRPF31,DDX23,LSM8,LSM4,MAGOH,SRSF10,SNRPD2,SNRPD3,SNRNP40,SNRPA,PPIH,THOC1,ZMAT2,HNRNPK,SNRNP70,DHX38,TRA2A,DHX15,LSM6,RP9,ALYREF,SF3B4,RBM22,NCBP2,SLU7,HNRNPA1,BUD31,SF3A1,SNRNP27
hsa03040	Spliceosome	3.12629906006833e-06	-12.675660661933	132	71	0.0288266341859521	2463	7161	56259,10285,57819,6427,6635,6629,11325,9128,6632,1655,57187,51362,27339,23658,988,10907,10084,6627,83443,84321,10713,7919,3183,3312,6432,6429,23451,26121,9416,8559,10929,51729,4116,25804,10772,6633,51691,6628,6426,55110,9879,6434,51503,9775,6637,8449,27258,51639,84991,22916,10569,10189,10262,55696,11017,3178,8896,10291,153527,6634,9410,6626,10465,9984,1665,29896,11157,6100,3190,9785,6625	CTNNBL1,SMNDC1,LSM2,SRSF2,SNRPE,SNRPB2,DDX42,PRPF4,SNRPD1,DDX5,THOC2,CDC40,PRPF19,LSM5,CDC5L,TXNL4A,PQBP1,SNRPA1,SF3B5,THOC3,USP39,DDX39B,HNRNPC,HSPA8,SRSF7,SRSF4,SF3B1,PRPF31,DDX23,PRPF18,SRSF8,WBP11,MAGOH,LSM4,SRSF10,SNRPD2,LSM8,SNRPB,SRSF1,MAGOHB,DDX46,TRA2B,CWC15,EIF4A3,SNRPG,DHX16,LSM3,SF3B6,RBM17,NCBP2,SLU7,ALYREF,SF3B4,RBM22,SNRNP27,HNRNPA1,BUD31,SF3A1,ZMAT2,SNRPD3,SNRNP40,SNRPA,PPIH,THOC1,DHX15,TRA2A,LSM6,RP9,HNRNPK,DHX38,SNRNP70
hsa05142	Chagas disease (American trypanosomiasis)	6.22041097845141e-06	-11.9876745796899	102	57	0.023142509135201	2463	7161	4615,10000,3456,7048,355,4790,7189,6352,5518,3569,4087,54106,3586,2776,3458,6348,7042,2775,2353,9630,2767,919,3576,917,5516,4792,3558,3592,148022,2771,5522,208,3725,3553,7124,5290,6347,7097,8503,5296,207,51135,4088,5330,2773,5295,7043,714,356,3551,5602,7099,10333,811,23236,3593,3459	MYD88,AKT3,IFNB1,TGFBR2,FAS,NFKB1,TRAF6,CCL5,PPP2R1A,IL6,SMAD2,TLR9,IL10,GNAQ,IFNG,CCL3,TGFB2,GNAO1,FOS,GNA14,GNA11,CD247,CXCL8,CD3G,PPP2CB,NFKBIA,IL2,IL12A,TICAM1,GNAI2,PPP2R2C,AKT2,JUN,IL1B,TNF,PIK3CA,CCL2,TLR2,PIK3R3,PIK3R2,AKT1,IRAK4,SMAD3,PLCB2,GNAI3,PIK3R1,TGFB3,C1QC,FASLG,IKBKB,MAPK10,TLR4,TLR6,CALR,PLCB1,IL12B,IFNGR1
ko05142	Chagas disease (American trypanosomiasis)	6.22041097845141e-06	-11.9876745796899	102	57	0.023142509135201	2463	7161	3553,5290,6347,7124,8503,7097,148022,5522,2771,3725,208,5602,3551,356,10333,7099,23236,811,3459,3593,5296,5330,4088,51135,207,5295,7043,2773,714,5518,3569,4087,3586,54106,3456,10000,4615,4790,7048,355,6352,7189,5516,917,3576,919,4792,3558,3592,2776,6348,3458,2353,2775,7042,2767,9630	IL1B,PIK3CA,CCL2,TNF,PIK3R3,TLR2,TICAM1,PPP2R2C,GNAI2,JUN,AKT2,MAPK10,IKBKB,FASLG,TLR6,TLR4,PLCB1,CALR,IFNGR1,IL12B,PIK3R2,PLCB2,SMAD3,IRAK4,AKT1,PIK3R1,TGFB3,GNAI3,C1QC,PPP2R1A,IL6,SMAD2,IL10,TLR9,IFNB1,AKT3,MYD88,NFKB1,TGFBR2,FAS,CCL5,TRAF6,PPP2CB,CD3G,CXCL8,CD247,NFKBIA,IL2,IL12A,GNAQ,CCL3,IFNG,FOS,GNAO1,TGFB2,GNA11,GNA14
hsa05206	MicroRNAs in cancer	6.80992783960656e-06	-11.8971290340989	299	139	0.0564352415753147	2463	7161	406918,4318,406913,27086,406996,5581,442910,406901,6464,407047,406885,406971,494324,3845,5728,406957,407014,693210,406933,5290,407053,406938,406959,442909,406943,406948,406886,406891,5579,406935,407044,407055,407021,1026,574457,407017,442904,1545,407034,407011,5894,406992,7422,406989,442891,406942,2033,407008,7976,4853,4233,27250,406904,1021,85414,407006,406910,406951,442918,407041,4790,578,406894,406928,5243,3190,5604,407029,6541,407020,406947,595,3551,406967,574455,1399,4193,1387,406884,406997,406937,407046,442898,5296,574031,406890,407036,406892,54541,6655,6093,406970,659,407035,407045,406917,407033,442903,406969,407043,406902,10642,406900,406982,1944,23405,693200,407026,3265,406985,7143,406905,7329,406950,442902,406952,554213,407030,672,7157,407040,406903,407042,7078,406988,494335,7042,406983,1027,407007,5578,442890,4609,407051,2146,406991,407010,4170,406893	MIR129-2,MMP9,MIR126,FOXP1,MIR214,PRKCE,MIR345,MIR107,SHC1,MIR9-2,MIRLET7C,MIR195,MIR375,KRAS,PTEN,MIR181C,MIR25,MIR625,MIR141,PIK3CA,MIR96,MIR146A,MIR183,MIR342,MIR152,MIR15A,MIRLET7D,MIRLET7I,PRKCB,MIR143,MIR7-2,MIR99A,MIR29A,CDKN1A,MIR181D,MIR26B,MIR335,CYP1B1,MIR30E,MIR23B,RAF1,MIR210,VEGFA,MIR206,MIR135B,MIR150,EP300,MIR223,FZD3,NOTCH2,MET,PDCD4,MIR1-1,CDK6,SLC45A3,MIR221,MIR125A,MIR16-2,MIR373,MIR34B,NFKB1,BAK1,MIR101-2,MIR137,ABCB1,HNRNPK,MAP2K1,MIR30A,SLC7A1,MIR28,MIR155,CCND1,IKBKB,MIR192,MIR193B,CRKL,MDM2,CREBBP,MIRLET7B,MIR215,MIR145,MIR9-1,MIR324,PIK3R2,MIR363,MIRLET7G,MIR32,MIR100,DDIT4,SOS2,ROCK1,MIR194-2,BMPR2,MIR31,MIR7-3,MIR129-1,MIR30D,MIR331,MIR194-1,MIR7-1,MIR10A,IGF2BP1,MIR106B,MIR20A,EFNA3,DICER1,MIR615,MIR29C,HRAS,MIR200C,TNR,MIR1-2,UBE2I,MIR16-1,MIR330,MIR17,MIR449A,MIR30B,BRCA1,TP53,MIR34A,MIR10B,MIR34C,TIMP3,MIR205,MIR423,TGFB2,MIR200A,CDKN1B,MIR222,PRKCA,MIR133B,MYC,MIR9-3,EZH2,MIR21,MIR23A,MCL1,MIR101-1
ko05206	MicroRNAs in cancer	6.80992783960656e-06	-11.8971290340989	299	139	0.0564352415753147	2463	7161	406904,27250,7976,4853,4233,85414,1021,7422,442891,406989,5894,407011,406992,407008,406942,2033,406894,3190,5243,406928,578,4790,6541,407029,5604,406910,406951,407006,407041,442918,406971,494324,406885,407047,693210,5728,3845,406957,407014,406913,406918,4318,406901,442910,5581,6464,406996,27086,407044,406935,1026,407021,407055,5579,407017,407034,442904,1545,574457,406938,406933,407053,5290,406886,406891,406948,406959,442909,406943,7157,672,442902,406950,407030,554213,406952,7042,494335,406983,407040,406988,406903,7078,407042,693200,7143,7329,406905,3265,407026,406985,2146,407051,407010,406991,442890,4609,406893,4170,1027,407007,5578,442898,5296,574031,407046,406890,406892,407036,3551,1387,4193,1399,574455,406967,406947,407020,595,406937,406997,406884,406969,442903,407033,1944,23405,406982,10642,406902,407043,406900,659,407035,6655,54541,6093,406970,407045,406917	MIR1-1,PDCD4,FZD3,NOTCH2,MET,SLC45A3,CDK6,VEGFA,MIR135B,MIR206,RAF1,MIR23B,MIR210,MIR223,MIR150,EP300,MIR101-2,HNRNPK,ABCB1,MIR137,BAK1,NFKB1,SLC7A1,MIR30A,MAP2K1,MIR125A,MIR16-2,MIR221,MIR34B,MIR373,MIR195,MIR375,MIRLET7C,MIR9-2,MIR625,PTEN,KRAS,MIR181C,MIR25,MIR126,MIR129-2,MMP9,MIR107,MIR345,PRKCE,SHC1,MIR214,FOXP1,MIR7-2,MIR143,CDKN1A,MIR29A,MIR99A,PRKCB,MIR26B,MIR30E,MIR335,CYP1B1,MIR181D,MIR146A,MIR141,MIR96,PIK3CA,MIRLET7D,MIRLET7I,MIR15A,MIR183,MIR342,MIR152,TP53,BRCA1,MIR330,MIR16-1,MIR30B,MIR449A,MIR17,TGFB2,MIR423,MIR200A,MIR34A,MIR205,MIR10B,TIMP3,MIR34C,MIR615,TNR,UBE2I,MIR1-2,HRAS,MIR29C,MIR200C,EZH2,MIR9-3,MIR23A,MIR21,MIR133B,MYC,MIR101-1,MCL1,CDKN1B,MIR222,PRKCA,MIR324,PIK3R2,MIR363,MIR9-1,MIRLET7G,MIR100,MIR32,IKBKB,CREBBP,MDM2,CRKL,MIR193B,MIR192,MIR155,MIR28,CCND1,MIR145,MIR215,MIRLET7B,MIR194-1,MIR331,MIR30D,EFNA3,DICER1,MIR20A,IGF2BP1,MIR10A,MIR7-1,MIR106B,BMPR2,MIR31,SOS2,DDIT4,ROCK1,MIR194-2,MIR7-3,MIR129-1
hsa00480	Glutathione metabolism	1.59963217266367e-05	-11.0431517542389	54	34	0.0138043036946813	2463	7161	3418,2877,2949,2880,2950,51056,6240,2941,2876,27306,2948,79017,9446,2539,2939,2729,4953,257202,119391,2879,4258,2947,3417,6723,51060,2878,4259,2952,2882,653689,2938,2946,2686,373156	IDH2,GPX2,GSTM5,GPX5,GSTP1,LAP3,RRM1,GSTA4,GPX1,HPGDS,GSTM4,GGCT,GSTO1,G6PD,GSTA2,GCLC,ODC1,GPX6,GSTO2,GPX4,MGST2,GSTM3,IDH1,SRM,TXNDC12,GPX3,MGST3,GSTT1,GPX7,GSTT2B,GSTA1,GSTM2,GGT7,GSTK1
ko00480	Glutathione metabolism	1.59963217266367e-05	-11.0431517542389	54	34	0.0138043036946813	2463	7161	2879,119391,2947,4258,2729,2939,257202,4953,2686,2946,2938,653689,373156,3417,2878,6723,51060,2952,4259,2882,2950,2880,51056,6240,2877,3418,2949,27306,79017,9446,2539,2948,2941,2876	GPX4,GSTO2,GSTM3,MGST2,GCLC,GSTA2,GPX6,ODC1,GGT7,GSTM2,GSTA1,GSTT2B,GSTK1,IDH1,GPX3,SRM,TXNDC12,GSTT1,MGST3,GPX7,GSTP1,GPX5,LAP3,RRM1,GPX2,IDH2,GSTM5,HPGDS,GGCT,GSTO1,G6PD,GSTM4,GSTA4,GPX1
ko05164	Influenza A	2.85055934637048e-05	-10.4654102280621	172	85	0.0345107592367032	2463	7161	8503,114548,5608,6041,3665,5644,7919,7124,55916,3312,5290,6347,3447,3553,7416,6772,3725,208,5045,1965,4599,5579,148022,3836,23586,29110,5340,3459,3593,91543,5606,4793,3606,7099,3454,10625,3551,356,5602,1387,4938,5295,10379,9021,51135,51284,207,3838,3717,5296,5611,5578,60,10898,29108,3569,3552,5604,6773,6352,64135,355,29107,4790,3446,4615,3456,8743,10000,3592,5610,2033,3661,4792,3576,5371,5894,3440,3716,3383,57506,7098,3627,3458,7514	PIK3R3,NLRP3,MAP2K6,RNASEL,IRF7,PRSS1,DDX39B,TNF,NXT2,HSPA8,PIK3CA,CCL2,IFNA13,IL1B,VDAC1,STAT1,JUN,AKT2,FURIN,EIF2S1,MX1,PRKCB,TICAM1,KPNA1,RIGI,TBK1,PLG,IFNGR1,IL12B,RSAD2,MAP2K3,NFKBIB,IL18,TLR4,IFNAR1,IVNS1ABP,IKBKB,FASLG,MAPK10,CREBBP,OAS1,PIK3R1,IRF9,SOCS3,IRAK4,TLR7,AKT1,KPNA2,JAK2,PIK3R2,DNAJC3,PRKCA,ACTB,CPSF4,PYCARD,IL6,IL1A,MAP2K1,STAT2,CCL5,IFIH1,FAS,NXT1,NFKB1,IFNA10,MYD88,IFNB1,TNFSF10,AKT3,IL12A,EIF2AK2,EP300,IRF3,NFKBIA,CXCL8,PML,RAF1,IFNA2,JAK1,ICAM1,MAVS,TLR3,CXCL10,IFNG,XPO1
hsa05164	Influenza A	2.85055934637048e-05	-10.4654102280621	172	85	0.0345107592367032	2463	7161	3312,55916,6347,5290,7124,7919,3447,3553,5608,6041,114548,8503,3665,5644,5579,148022,4599,1965,5340,29110,3836,23586,3725,208,7416,6772,5045,3454,3606,7099,5602,1387,3551,10625,356,3459,3593,4793,5606,91543,3838,3717,51284,51135,207,5611,5296,4938,9021,5295,10379,3569,3552,5578,10898,29108,60,4790,29107,3446,355,3456,10000,8743,4615,6352,5604,6773,64135,3576,5894,5371,3383,3440,3716,5610,2033,3592,3661,4792,3458,3627,7514,7098,57506	HSPA8,NXT2,CCL2,PIK3CA,TNF,DDX39B,IFNA13,IL1B,MAP2K6,RNASEL,NLRP3,PIK3R3,IRF7,PRSS1,PRKCB,TICAM1,MX1,EIF2S1,PLG,TBK1,KPNA1,RIGI,JUN,AKT2,VDAC1,STAT1,FURIN,IFNAR1,IL18,TLR4,MAPK10,CREBBP,IKBKB,IVNS1ABP,FASLG,IFNGR1,IL12B,NFKBIB,MAP2K3,RSAD2,KPNA2,JAK2,TLR7,IRAK4,AKT1,DNAJC3,PIK3R2,OAS1,SOCS3,PIK3R1,IRF9,IL6,IL1A,PRKCA,CPSF4,PYCARD,ACTB,NFKB1,NXT1,IFNA10,FAS,IFNB1,AKT3,TNFSF10,MYD88,CCL5,MAP2K1,STAT2,IFIH1,CXCL8,RAF1,PML,ICAM1,IFNA2,JAK1,EIF2AK2,EP300,IL12A,IRF3,NFKBIA,IFNG,CXCL10,XPO1,TLR3,MAVS
M00340	Proteasome, 20S core particle	4.51033344949793e-05	-10.0065543786016	15	13	0.00527811611855461	2463	7161	5685,5683,5682,5695,5686,5692,5693,5691,5694,5689,5690,5684,5687	PSMA4,PSMA2,PSMA1,PSMB7,PSMA5,PSMB4,PSMB5,PSMB3,PSMB6,PSMB1,PSMB2,PSMA3,PSMA6
hsa_M00340	Proteasome, 20S core particle	4.51033344949793e-05	-10.0065543786016	15	13	0.00527811611855461	2463	7161	5685,5683,5682,5686,5695,5693,5692,5691,5694,5689,5690,5684,5687	PSMA4,PSMA2,PSMA1,PSMA5,PSMB7,PSMB5,PSMB4,PSMB3,PSMB6,PSMB1,PSMB2,PSMA3,PSMA6
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	4.74561337120515e-05	-9.95570477441218	145	73	0.0296386520503451	2463	7161	7124,5290,4711,3553,55967,581,4697,5571,8503,1349,1965,4722,6391,4706,208,3725,4714,1351,4726,10975,4713,4694,27089,356,3551,5465,7186,5602,4720,1339,9370,207,998,5296,4296,125965,7384,4728,3952,84701,5295,9021,5564,170712,3552,79602,3569,1340,6390,7385,4718,9377,355,4790,10000,1649,4695,4710,3576,7494,4729,4712,7388,1537,468,2931,4716,51094,1346,1327,4698,1345,3953	TNF,PIK3CA,NDUFB5,IL1B,NDUFA12,BAX,NDUFA4,PRKAG1,PIK3R3,COX7B,EIF2S1,NDUFS3,SDHC,NDUFAB1,AKT2,JUN,NDUFB8,COX8A,NDUFS6,UQCR11,NDUFB7,NDUFA1,UQCRQ,FASLG,IKBKB,PPARA,TRAF2,MAPK10,NDUFS2,COX6A2,ADIPOQ,AKT1,CDC42,PIK3R2,MAP3K11,COX6B2,UQCRC1,NDUFS8,LEP,COX4I2,PIK3R1,SOCS3,PRKAB1,COX7B2,IL1A,ADIPOR2,IL6,COX6B1,SDHB,UQCRC2,NDUFC2,COX5A,FAS,NFKB1,AKT3,DDIT3,NDUFA2,NDUFB4,CXCL8,XBP1,NDUFV2,NDUFB6,UQCRH,CYC1,ATF4,GSK3A,NDUFB10,ADIPOR1,COX7A1,COX4I1,NDUFA5,COX6C,LEPR
ko04932	Non-alcoholic fatty liver disease (NAFLD)	4.74561337120515e-05	-9.95570477441218	145	73	0.0296386520503451	2463	7161	7385,6390,9377,4718,170712,5564,1340,3569,79602,3552,4695,4710,4790,355,1649,10000,4716,51094,4712,4729,7494,3576,2931,468,1537,7388,3953,1345,1346,4698,1327,8503,1349,5290,4711,7124,55967,5571,4697,581,3553,3725,208,4706,4726,1351,4714,1965,6391,4722,1339,4720,9370,4713,10975,5602,5465,7186,3551,356,27089,4694,3952,4728,9021,5295,84701,207,7384,4296,998,125965,5296	UQCRC2,SDHB,COX5A,NDUFC2,COX7B2,PRKAB1,COX6B1,IL6,ADIPOR2,IL1A,NDUFA2,NDUFB4,NFKB1,FAS,DDIT3,AKT3,NDUFB10,ADIPOR1,NDUFB6,NDUFV2,XBP1,CXCL8,GSK3A,ATF4,CYC1,UQCRH,LEPR,COX6C,COX7A1,NDUFA5,COX4I1,PIK3R3,COX7B,PIK3CA,NDUFB5,TNF,NDUFA12,PRKAG1,NDUFA4,BAX,IL1B,JUN,AKT2,NDUFAB1,NDUFS6,COX8A,NDUFB8,EIF2S1,SDHC,NDUFS3,COX6A2,NDUFS2,ADIPOQ,NDUFB7,UQCR11,MAPK10,PPARA,TRAF2,IKBKB,FASLG,UQCRQ,NDUFA1,LEP,NDUFS8,SOCS3,PIK3R1,COX4I2,AKT1,UQCRC1,MAP3K11,CDC42,COX6B2,PIK3R2
hsa_M00337	Immunoproteasome	6.79097646051356e-05	-9.59733072512148	17	14	0.00568412505075112	2463	7161	5685,5682,5683,5721,5698,5686,5692,5691,5690,5689,5720,5684,5699,5687	PSMA4,PSMA1,PSMA2,PSME2,PSMB9,PSMA5,PSMB4,PSMB3,PSMB2,PSMB1,PSME1,PSMA3,PSMB10,PSMA6
M00337	Immunoproteasome	6.79097646051356e-05	-9.59733072512148	17	14	0.00568412505075112	2463	7161	5692,5691,5686,5698,5721,5683,5682,5685,5699,5687,5684,5720,5690,5689	PSMB4,PSMB3,PSMA5,PSMB9,PSME2,PSMA2,PSMA1,PSMA4,PSMB10,PSMA6,PSMA3,PSME1,PSMB2,PSMB1
M00354	Spliceosome, U4/U6.U5 tri-snRNP	7.24475182236096e-05	-9.53264814480694	30	21	0.00852618757612668	2463	7161	10907,27258,11157,6637,9410,10465,23658,6634,6628,51691,9128,11017,6633,6632,6635,25804,10421,10713,57819,26121,9416	TXNL4A,LSM3,LSM6,SNRPG,SNRNP40,PPIH,LSM5,SNRPD3,SNRPB,LSM8,PRPF4,SNRNP27,SNRPD2,SNRPD1,SNRPE,LSM4,CD2BP2,USP39,LSM2,PRPF31,DDX23
hsa_M00354	Spliceosome, U4/U6.U5 tri-snRNP	7.24475182236096e-05	-9.53264814480694	30	21	0.00852618757612668	2463	7161	26121,9416,10713,57819,11017,9128,6632,6633,6635,25804,10421,51691,6628,6637,9410,10465,23658,6634,10907,27258,11157	PRPF31,DDX23,USP39,LSM2,SNRNP27,PRPF4,SNRPD1,SNRPD2,SNRPE,LSM4,CD2BP2,LSM8,SNRPB,SNRPG,SNRNP40,PPIH,LSM5,SNRPD3,TXNL4A,LSM3,LSM6
hsa03060	Protein export	0.000124529283398389	-8.99096966169739	23	17	0.00690215184734064	2463	7161	58477,11231,29927,9789,83943,60559,23480,3309,28972,6734,55176,23478,7095,6731,6729,6727,10952	SRPRB,SEC63,SEC61A1,SPCS2,IMMP2L,SPCS3,SEC61G,HSPA5,SPCS1,SRPRA,SEC61A2,SEC11A,SEC62,SRP72,SRP54,SRP14,SEC61B
ko03060	Protein export	0.000124529283398389	-8.99096966169739	23	17	0.00690215184734064	2463	7161	28972,6734,29927,11231,58477,9789,3309,23480,83943,60559,10952,6727,23478,55176,6731,7095,6729	SPCS1,SRPRA,SEC61A1,SEC63,SRPRB,SPCS2,HSPA5,SEC61G,IMMP2L,SPCS3,SEC61B,SRP14,SEC11A,SEC61A2,SRP72,SEC62,SRP54
hsa05418	Fluid shear stress and atherosclerosis	0.000155940664217627	-8.76603498064834	142	70	0.0284206252537556	2463	7161	119391,5295,4258,207,5296,2946,7341,2938,90,658,859,4318,857,6612,3551,2952,1843,5602,406902,208,2950,3725,6383,858,8503,5880,4880,5608,2948,7124,6347,5290,3553,659,657,4780,3685,3326,2947,2353,3458,7056,2939,3163,7157,51806,6714,1728,653689,7850,4208,8878,6613,7422,4259,3383,1499,6385,2817,7295,7184,4790,10000,2949,3320,9446,60,4205,2941,3552	GSTO2,PIK3R1,MGST2,AKT1,PIK3R2,GSTM2,SUMO1,GSTA1,ACVR1,BMPR1B,CAV3,MMP9,CAV1,SUMO3,IKBKB,GSTT1,DUSP1,MAPK10,MIR10A,AKT2,GSTP1,JUN,SDC2,CAV2,PIK3R3,RAC2,NPPC,MAP2K6,GSTM4,TNF,CCL2,PIK3CA,IL1B,BMPR2,BMPR1A,NFE2L2,ITGAV,HSP90AB1,GSTM3,FOS,IFNG,THBD,GSTA2,HMOX2,TP53,CALML5,SRC,NQO1,GSTT2B,IL1R2,MEF2C,SQSTM1,SUMO2,VEGFA,MGST3,ICAM1,CTNNB1,SDC4,GPC1,TXN,HSP90B1,NFKB1,AKT3,GSTM5,HSP90AA1,GSTO1,ACTB,MEF2A,GSTA4,IL1A
ko05418	Fluid shear stress and atherosclerosis	0.000155940664217627	-8.76603498064834	142	70	0.0284206252537556	2463	7161	653689,6714,1728,4208,7850,6613,8878,4259,3383,7422,4780,2353,2947,3326,3685,7056,3163,2939,3458,51806,7157,3320,60,9446,2941,4205,3552,1499,7295,2817,6385,4790,7184,2949,10000,90,2938,7341,2946,658,6612,857,4318,859,5602,1843,2952,3551,119391,4258,5295,207,5296,5608,5880,4880,8503,858,2948,5290,6347,7124,657,659,3553,2950,3725,208,406902,6383	GSTT2B,SRC,NQO1,MEF2C,IL1R2,SUMO2,SQSTM1,MGST3,ICAM1,VEGFA,NFE2L2,FOS,GSTM3,HSP90AB1,ITGAV,THBD,HMOX2,GSTA2,IFNG,CALML5,TP53,HSP90AA1,ACTB,GSTO1,GSTA4,MEF2A,IL1A,CTNNB1,TXN,GPC1,SDC4,NFKB1,HSP90B1,GSTM5,AKT3,ACVR1,GSTA1,SUMO1,GSTM2,BMPR1B,SUMO3,CAV1,MMP9,CAV3,MAPK10,DUSP1,GSTT1,IKBKB,GSTO2,MGST2,PIK3R1,AKT1,PIK3R2,MAP2K6,RAC2,NPPC,PIK3R3,CAV2,GSTM4,PIK3CA,CCL2,TNF,BMPR1A,BMPR2,IL1B,GSTP1,JUN,AKT2,MIR10A,SDC2
ko05220	Chronic myeloid leukemia	0.000289575040455334	-8.14709608743998	71	39	0.0158343483556638	2463	7161	598,4193,5781,1399,3551,5925,595,5894,6464,4792,4089,3265,5296,7157,4088,207,5295,1021,7042,7043,3845,53358,5290,1027,6655,572,8503,1026,10000,4790,4609,861,6776,7048,1019,867,208,5604,1487	BCL2L1,MDM2,PTPN11,CRKL,IKBKB,RB1,CCND1,RAF1,SHC1,NFKBIA,SMAD4,HRAS,PIK3R2,TP53,SMAD3,AKT1,PIK3R1,CDK6,TGFB2,TGFB3,KRAS,SHC3,PIK3CA,CDKN1B,SOS2,BAD,PIK3R3,CDKN1A,AKT3,NFKB1,MYC,RUNX1,STAT5A,TGFBR2,CDK4,CBL,AKT2,MAP2K1,CTBP1
hsa05220	Chronic myeloid leukemia	0.000289575040455334	-8.14709608743998	71	39	0.0158343483556638	2463	7161	595,5925,5894,1399,5781,4193,598,3551,4089,3265,4792,6464,4088,207,5296,7157,53358,3845,7043,1021,7042,5295,5290,6655,572,1027,8503,6776,861,4609,4790,7048,10000,1026,208,1487,5604,1019,867	CCND1,RB1,RAF1,CRKL,PTPN11,MDM2,BCL2L1,IKBKB,SMAD4,HRAS,NFKBIA,SHC1,SMAD3,AKT1,PIK3R2,TP53,SHC3,KRAS,TGFB3,CDK6,TGFB2,PIK3R1,PIK3CA,SOS2,BAD,CDKN1B,PIK3R3,STAT5A,RUNX1,MYC,NFKB1,TGFBR2,AKT3,CDKN1A,AKT2,CTBP1,MAP2K1,CDK4,CBL
hsa05012	Parkinson's disease	0.000451456459185195	-7.70303162567066	129	63	0.02557856272838	2463	7161	7417,4718,9377,10105,6390,7385,1340,7327,1812,170712,515,4710,27429,518,514,4695,522,83447,7332,4716,1537,292,7388,4712,4729,5567,513,6531,506,1345,4698,1327,1346,1349,55967,4697,4711,4726,1351,4714,2771,7416,4706,6391,539,10476,4722,291,7314,1339,516,4720,498,27089,4694,4713,10975,2773,84701,4728,7384,2861,125965	VDAC2,NDUFC2,COX5A,PPIF,SDHB,UQCRC2,COX6B1,UBE2G2,DRD1,COX7B2,ATP5PB,NDUFB4,HTRA2,ATP5MC3,ATP5F1E,NDUFA2,ATP5PF,SLC25A31,UBE2L3,NDUFB10,CYC1,SLC25A5,UQCRH,NDUFB6,NDUFV2,PRKACB,ATP5F1D,SLC6A3,ATP5F1B,COX6C,NDUFA5,COX4I1,COX7A1,COX7B,NDUFA12,NDUFA4,NDUFB5,NDUFS6,COX8A,NDUFB8,GNAI2,VDAC1,NDUFAB1,SDHC,ATP5PO,ATP5PD,NDUFS3,SLC25A4,UBB,COX6A2,ATP5MC1,NDUFS2,ATP5F1A,UQCRQ,NDUFA1,NDUFB7,UQCR11,GNAI3,COX4I2,NDUFS8,UQCRC1,GPR37,COX6B2
hsa00190	Oxidative phosphorylation	0.000544016809544329	-7.51653041168806	120	59	0.023954526999594	2463	7161	4713,10975,498,523,10632,27089,4694,1339,516,4720,7384,125965,4728,1353,534,84701,4711,528,55967,90423,4697,1349,539,6391,4722,10476,533,10063,4706,4726,1351,51382,4714,4712,4729,9550,7388,1537,4716,1346,4698,1327,506,1345,513,1352,170712,1340,7385,6390,8992,9377,4718,522,518,514,4695,4710,515	NDUFB7,UQCR11,ATP5F1A,ATP6V1A,ATP5MG,UQCRQ,NDUFA1,COX6A2,ATP5MC1,NDUFS2,UQCRC1,COX6B2,NDUFS8,COX11,ATP6V1G2,COX4I2,NDUFB5,ATP6V1C1,NDUFA12,ATP6V1E2,NDUFA4,COX7B,ATP5PO,SDHC,NDUFS3,ATP5PD,ATP6V0B,COX17,NDUFAB1,NDUFS6,COX8A,ATP6V1D,NDUFB8,NDUFB6,NDUFV2,ATP6V1G1,UQCRH,CYC1,NDUFB10,COX7A1,NDUFA5,COX4I1,ATP5F1B,COX6C,ATP5F1D,COX10,COX7B2,COX6B1,UQCRC2,SDHB,ATP6V0E1,COX5A,NDUFC2,ATP5PF,ATP5MC3,ATP5F1E,NDUFA2,NDUFB4,ATP5PB
ko00190	Oxidative phosphorylation	0.000544016809544329	-7.51653041168806	120	59	0.023954526999594	2463	7161	4716,4712,4729,9550,1537,7388,506,1345,1352,513,1346,4698,1327,8992,6390,7385,4718,9377,170712,1340,518,514,4695,4710,515,522,1339,516,4720,4713,10975,10632,523,498,27089,4694,4728,1353,534,84701,7384,125965,1349,528,4711,4697,90423,55967,10063,533,4706,51382,4726,1351,4714,6391,539,10476,4722	NDUFB10,NDUFB6,NDUFV2,ATP6V1G1,CYC1,UQCRH,ATP5F1B,COX6C,COX10,ATP5F1D,COX7A1,NDUFA5,COX4I1,ATP6V0E1,SDHB,UQCRC2,NDUFC2,COX5A,COX7B2,COX6B1,ATP5MC3,ATP5F1E,NDUFA2,NDUFB4,ATP5PB,ATP5PF,COX6A2,ATP5MC1,NDUFS2,NDUFB7,UQCR11,ATP5MG,ATP6V1A,ATP5F1A,UQCRQ,NDUFA1,NDUFS8,COX11,ATP6V1G2,COX4I2,UQCRC1,COX6B2,COX7B,ATP6V1C1,NDUFB5,NDUFA4,ATP6V1E2,NDUFA12,COX17,ATP6V0B,NDUFAB1,ATP6V1D,NDUFS6,COX8A,NDUFB8,SDHC,ATP5PO,ATP5PD,NDUFS3
ko04137	Mitophagy - animal	0.000652643803818109	-7.33447905405624	64	35	0.0142103126268778	2463	7161	23710,22808,9958,1460,22800,79065,139341,29110,665,7942,11337,7314,4286,1457,11345,84749,51024,3725,8678,54543,7030,468,598,5602,79735,8878,10133,6714,9101,3265,6667,7157,55669,3845,8887	GABARAPL1,MRAS,USP15,CSNK2B,RRAS2,ATG9A,FUNDC1,TBK1,BNIP3L,TFEB,GABARAP,UBB,MITF,CSNK2A1,GABARAPL2,USP30,FIS1,JUN,BECN1,TOMM7,TFE3,ATF4,BCL2L1,MAPK10,TBC1D17,SQSTM1,OPTN,SRC,USP8,HRAS,SP1,TP53,MFN1,KRAS,TAX1BP1
hsa04137	Mitophagy - animal	0.000652643803818109	-7.33447905405624	64	35	0.0142103126268778	2463	7161	3265,9101,6714,6667,10133,79735,8878,7030,8678,54543,598,5602,468,3845,8887,55669,7157,9958,1460,22800,22808,23710,51024,3725,84749,1457,4286,11345,7942,7314,11337,139341,79065,29110,665	HRAS,USP8,SRC,SP1,OPTN,TBC1D17,SQSTM1,TFE3,BECN1,TOMM7,BCL2L1,MAPK10,ATF4,KRAS,TAX1BP1,MFN1,TP53,USP15,CSNK2B,RRAS2,MRAS,GABARAPL1,FIS1,JUN,USP30,CSNK2A1,MITF,GABARAPL2,TFEB,UBB,GABARAP,FUNDC1,ATG9A,TBK1,BNIP3L
hsa05166	HTLV-I infection	0.00098363289626247	-6.92425780342502	256	112	0.0454730004060089	2463	7161	595,54107,3551,4605,598,1387,8322,207,4088,5296,7043,7124,5425,5901,8503,7480,5111,991,3600,7476,7416,56655,7472,7494,5567,292,5902,3383,3265,3558,8323,1856,5535,4049,29945,4792,7157,200186,4488,1385,57804,1437,7042,8829,1739,1958,22800,958,467,22808,7048,3561,4609,5530,29882,8697,2005,1499,9232,55697,9184,811,4215,3559,3845,246184,5295,5290,4801,8881,581,896,4487,1031,3560,291,1959,6776,1026,466,4055,706,3725,208,4085,1019,917,5925,9020,3716,468,2033,4089,83447,7850,7976,109,7514,2353,51529,4087,94241,3569,5423,3601,7417,4790,10000,7015,2002,108,6513	CCND1,POLE3,IKBKB,MYBL2,BCL2L1,CREBBP,FZD4,AKT1,SMAD3,PIK3R2,TGFB3,TNF,POLD2,RAN,PIK3R3,WNT10B,PCNA,CDC20,IL15,WNT7A,VDAC1,POLE4,WNT2,XBP1,PRKACB,SLC25A5,RANBP1,ICAM1,HRAS,IL2,FZD6,DVL2,PPP3R2,LTA,ANAPC4,NFKBIA,TP53,CRTC2,MSX2,CREB1,POLD4,CSF2,TGFB2,NRP1,DLG1,EGR1,RRAS2,CD40,ATF3,MRAS,TGFBR2,IL2RG,MYC,PPP3CA,ANAPC2,CDC23,ELK4,CTNNB1,PTTG1,VAC14,BUB3,CALR,MAP3K3,IL2RA,KRAS,CDC26,PIK3R1,PIK3CA,NFYB,CDC16,BAX,CCND3,MSX1,CDKN2C,IL2RB,SLC25A4,EGR2,STAT5A,CDKN1A,ATF1,LTBR,TSPO,JUN,AKT2,MAD2L1,CDK4,CD3G,RB1,MAP3K14,JAK1,ATF4,EP300,SMAD4,SLC25A31,IL1R2,FZD3,ADCY3,XPO1,FOS,ANAPC11,SMAD2,TP53INP1,IL6,POLB,IL15RA,VDAC2,NFKB1,AKT3,TERT,ELK1,ADCY2,SLC2A1
ko05166	HTLV-I infection	0.00098363289626247	-6.92425780342502	256	112	0.0454730004060089	2463	7161	8503,5111,7480,5425,5901,7124,7472,7416,56655,3600,7476,991,8322,54107,3551,4605,598,1387,595,7043,5296,207,4088,467,22808,1958,958,22800,1739,8829,2005,1499,5530,29882,8697,7048,3561,4609,29945,4792,3265,3558,8323,1856,5535,4049,292,3383,5902,7494,5567,1437,7042,4488,1385,57804,7157,200186,3560,4487,1031,581,8881,896,5290,4801,4085,1019,4055,706,3725,208,1026,466,291,1959,6776,811,9232,55697,9184,5295,246184,3845,4215,3559,7417,3601,94241,3569,5423,51529,4087,6513,2002,108,7015,10000,4790,83447,7850,2033,4089,3716,468,917,5925,9020,2353,7514,7976,109	PIK3R3,PCNA,WNT10B,POLD2,RAN,TNF,WNT2,VDAC1,POLE4,IL15,WNT7A,CDC20,FZD4,POLE3,IKBKB,MYBL2,BCL2L1,CREBBP,CCND1,TGFB3,PIK3R2,AKT1,SMAD3,ATF3,MRAS,EGR1,CD40,RRAS2,DLG1,NRP1,ELK4,CTNNB1,PPP3CA,ANAPC2,CDC23,TGFBR2,IL2RG,MYC,ANAPC4,NFKBIA,HRAS,IL2,FZD6,DVL2,PPP3R2,LTA,SLC25A5,ICAM1,RANBP1,XBP1,PRKACB,CSF2,TGFB2,MSX2,CREB1,POLD4,TP53,CRTC2,IL2RB,MSX1,CDKN2C,BAX,CDC16,CCND3,PIK3CA,NFYB,MAD2L1,CDK4,LTBR,TSPO,JUN,AKT2,CDKN1A,ATF1,SLC25A4,EGR2,STAT5A,CALR,PTTG1,VAC14,BUB3,PIK3R1,CDC26,KRAS,MAP3K3,IL2RA,VDAC2,IL15RA,TP53INP1,IL6,POLB,ANAPC11,SMAD2,SLC2A1,ELK1,ADCY2,TERT,AKT3,NFKB1,SLC25A31,IL1R2,EP300,SMAD4,JAK1,ATF4,CD3G,RB1,MAP3K14,FOS,XPO1,FZD3,ADCY3
ko05143	African trypanosomiasis	0.00098862937559141	-6.91919104319805	34	21	0.00852618757612668	2463	7161	355,3620,3458,5579,5330,3043,4615,2776,7124,3606,3039,3553,356,3569,3383,3592,3593,5578,54106,3586,23236	FAS,IDO1,IFNG,PRKCB,PLCB2,HBB,MYD88,GNAQ,TNF,IL18,HBA1,IL1B,FASLG,IL6,ICAM1,IL12A,IL12B,PRKCA,TLR9,IL10,PLCB1
hsa05143	African trypanosomiasis	0.00098862937559141	-6.91919104319805	34	21	0.00852618757612668	2463	7161	3620,3458,355,5579,5330,3043,4615,2776,3606,7124,3039,356,3553,3569,3383,3592,3593,54106,5578,3586,23236	IDO1,IFNG,FAS,PRKCB,PLCB2,HBB,MYD88,GNAQ,IL18,TNF,HBA1,FASLG,IL1B,IL6,ICAM1,IL12A,IL12B,TLR9,PRKCA,IL10,PLCB1
hsa_M00352	Spliceosome, U2-snRNP	0.00123292139046652	-6.69836881152292	20	14	0.00568412505075112	2463	7161	23451,51639,6628,6637,6634,6633,6632,6635,6629,11325,10291,6627,83443,10262	SF3B1,SF3B6,SNRPB,SNRPG,SNRPD3,SNRPD2,SNRPD1,SNRPE,SNRPB2,DDX42,SF3A1,SNRPA1,SF3B5,SF3B4
M00352	Spliceosome, U2-snRNP	0.00123292139046652	-6.69836881152292	20	14	0.00568412505075112	2463	7161	6629,6635,11325,6632,6633,10291,6627,83443,10262,51639,23451,6628,6634,6637	SNRPB2,SNRPE,DDX42,SNRPD1,SNRPD2,SF3A1,SNRPA1,SF3B5,SF3B4,SF3B6,SF3B1,SNRPB,SNRPD3,SNRPG
hsa01524	Platinum drug resistance	0.00136619458958663	-6.59572607586568	73	38	0.0154283394234673	2463	7161	2950,208,355,5366,578,2949,10000,1026,8503,9446,2948,572,5290,1317,2941,581,1244,119391,5295,2947,4258,207,2939,672,5296,7157,2946,653689,2938,7155,2956,332,356,598,2952,329,4259,4193	GSTP1,AKT2,FAS,PMAIP1,BAK1,GSTM5,AKT3,CDKN1A,PIK3R3,GSTO1,GSTM4,BAD,PIK3CA,SLC31A1,GSTA4,BAX,ABCC2,GSTO2,PIK3R1,GSTM3,MGST2,AKT1,GSTA2,BRCA1,PIK3R2,TP53,GSTM2,GSTT2B,GSTA1,TOP2B,MSH6,BIRC5,FASLG,BCL2L1,GSTT1,BIRC2,MGST3,MDM2
ko01524	Platinum drug resistance	0.00136619458958663	-6.59572607586568	73	38	0.0154283394234673	2463	7161	2956,2946,2938,7155,653689,356,4259,329,2952,4193,598,332,5295,2947,4258,1244,119391,5296,7157,672,207,2939,9446,2948,8503,581,572,2941,1317,5290,208,2950,1026,10000,2949,355,5366,578	MSH6,GSTM2,GSTA1,TOP2B,GSTT2B,FASLG,MGST3,BIRC2,GSTT1,MDM2,BCL2L1,BIRC5,PIK3R1,GSTM3,MGST2,ABCC2,GSTO2,PIK3R2,TP53,BRCA1,AKT1,GSTA2,GSTO1,GSTM4,PIK3R3,BAX,BAD,GSTA4,SLC31A1,PIK3CA,AKT2,GSTP1,CDKN1A,AKT3,GSTM5,FAS,PMAIP1,BAK1
hsa05160	Hepatitis C	0.00137744279884259	-6.58752654314054	131	62	0.0251725537961835	2463	7161	975,5518,3949,10000,3456,3446,4790,100132463,7189,6773,9074,8554,9073,3716,3440,5516,5894,3576,4792,3661,23562,5610,3265,3646,7157,1364,7098,57506,5010,3447,5290,6655,572,7124,3659,53842,3665,6041,1365,8503,1026,29110,23586,148022,1965,5522,208,6772,7186,5465,5602,3551,3454,9076,5296,9080,207,9021,10379,5295,4938,3845	CD81,PPP2R1A,LDLR,AKT3,IFNB1,IFNA10,NFKB1,CLDN24,TRAF6,STAT2,CLDN6,PIAS1,CLDN8,JAK1,IFNA2,PPP2CB,RAF1,CXCL8,NFKBIA,IRF3,CLDN14,EIF2AK2,HRAS,EIF3E,TP53,CLDN4,TLR3,MAVS,CLDN11,IFNA13,PIK3CA,SOS2,BAD,TNF,IRF1,CLDN22,IRF7,RNASEL,CLDN3,PIK3R3,CDKN1A,TBK1,RIGI,TICAM1,EIF2S1,PPP2R2C,AKT2,STAT1,TRAF2,PPARA,MAPK10,IKBKB,IFNAR1,CLDN1,PIK3R2,CLDN9,AKT1,SOCS3,IRF9,PIK3R1,OAS1,KRAS
ko05160	Hepatitis C	0.00137744279884259	-6.58752654314054	131	62	0.0251725537961835	2463	7161	3665,53842,3659,8503,1365,6041,3447,5010,572,6655,7124,5290,5522,6772,208,23586,1026,29110,1965,148022,9076,3551,5602,7186,5465,3454,5295,10379,9021,3845,4938,5296,207,9080,3949,5518,975,100132463,9074,6773,7189,3456,10000,4790,3446,23562,3661,4792,3265,5610,3716,3440,9073,8554,3576,5894,5516,7098,57506,1364,3646,7157	IRF7,CLDN22,IRF1,PIK3R3,CLDN3,RNASEL,IFNA13,CLDN11,BAD,SOS2,TNF,PIK3CA,PPP2R2C,STAT1,AKT2,RIGI,CDKN1A,TBK1,EIF2S1,TICAM1,CLDN1,IKBKB,MAPK10,TRAF2,PPARA,IFNAR1,PIK3R1,IRF9,SOCS3,KRAS,OAS1,PIK3R2,AKT1,CLDN9,LDLR,PPP2R1A,CD81,CLDN24,CLDN6,STAT2,TRAF6,IFNB1,AKT3,NFKB1,IFNA10,CLDN14,IRF3,NFKBIA,HRAS,EIF2AK2,JAK1,IFNA2,CLDN8,PIAS1,CXCL8,RAF1,PPP2CB,TLR3,MAVS,CLDN4,EIF3E,TP53
hsa05169	Epstein-Barr virus infection	0.00141141063383704	-6.56316562517834	199	89	0.0361347949654892	2463	7161	3383,5709,5567,5704,4792,5610,7157,7534,3458,5435,6850,1027,5707,5718,1460,958,3586,4609,1457,7189,2268,3551,4193,1387,5602,5713,5606,4793,5700,7185,5441,5296,207,2961,956,5901,3315,7979,8503,7529,5608,29110,5705,952,3716,9020,5925,2960,3516,3661,51082,2033,7514,10213,965,5432,5436,10014,84265,10454,7533,10000,55703,7128,2959,4790,5438,11047,5710,7186,890,171568,26993,9861,5433,5295,5290,3312,3316,7532,23118,983,23586,1026,5431,10621,5702,208,3725	ICAM1,PSMD3,PRKACB,PSMC4,NFKBIA,EIF2AK2,TP53,YWHAZ,IFNG,POLR2F,SYK,CDKN1B,PSMD1,PSMD12,CSNK2B,CD40,IL10,MYC,CSNK2A1,TRAF6,FGR,IKBKB,MDM2,CREBBP,MAPK10,PSMD7,MAP2K3,NFKBIB,PSMC1,TRAF1,POLR2L,PIK3R2,AKT1,GTF2E2,ENTPD3,RAN,HSPB1,SEM1,PIK3R3,YWHAB,MAP2K6,TBK1,PSMC5,CD38,JAK1,MAP3K14,RB1,GTF2E1,RBPJ,IRF3,POLR1D,EP300,XPO1,PSMD14,CD58,POLR2C,POLR2G,HDAC5,POLR3GL,TAB1,YWHAH,AKT3,POLR3B,TNFAIP3,GTF2B,NFKB1,POLR2I,ADRM1,PSMD4,TRAF2,CCNA2,POLR3H,AKAP8L,PSMD6,POLR2D,PIK3R1,PIK3CA,HSPA8,HSPB2,YWHAG,TAB2,CDK1,RIGI,CDKN1A,POLR2B,POLR3F,PSMC3,AKT2,JUN
ko05169	Epstein-Barr virus infection	0.00141141063383704	-6.56316562517834	199	89	0.0361347949654892	2463	7161	29110,5705,952,5901,3315,7979,5608,7529,8503,5441,5296,2961,207,956,1387,4193,5602,3551,5713,4793,5700,7185,5606,4609,1457,2268,7189,1027,5718,5707,958,3586,1460,7157,7534,5435,3458,6850,3383,5709,5567,4792,5704,5610,1026,23586,983,5702,10621,5431,208,3725,5290,3312,7532,23118,3316,26993,9861,5433,5295,7186,890,171568,10000,2959,7128,4790,55703,5710,5438,11047,84265,10454,7533,10213,7514,5432,965,5436,10014,3716,9020,5925,2960,3516,3661,51082,2033	TBK1,PSMC5,CD38,RAN,HSPB1,SEM1,MAP2K6,YWHAB,PIK3R3,POLR2L,PIK3R2,GTF2E2,AKT1,ENTPD3,CREBBP,MDM2,MAPK10,IKBKB,PSMD7,NFKBIB,PSMC1,TRAF1,MAP2K3,MYC,CSNK2A1,FGR,TRAF6,CDKN1B,PSMD12,PSMD1,CD40,IL10,CSNK2B,TP53,YWHAZ,POLR2F,IFNG,SYK,ICAM1,PSMD3,PRKACB,NFKBIA,PSMC4,EIF2AK2,CDKN1A,RIGI,CDK1,PSMC3,POLR3F,POLR2B,AKT2,JUN,PIK3CA,HSPA8,YWHAG,TAB2,HSPB2,AKAP8L,PSMD6,POLR2D,PIK3R1,TRAF2,CCNA2,POLR3H,AKT3,GTF2B,TNFAIP3,NFKB1,POLR3B,PSMD4,POLR2I,ADRM1,POLR3GL,TAB1,YWHAH,PSMD14,XPO1,POLR2C,CD58,POLR2G,HDAC5,JAK1,MAP3K14,RB1,GTF2E1,RBPJ,IRF3,POLR1D,EP300
ko04660	T cell receptor signaling pathway	0.00152011952127233	-6.48896631479931	102	50	0.0203004466098254	2463	7161	998,5296,207,3565,5295,3845,3551,4793,7410,5133,9402,57144,867,3702,1019,208,3725,940,7124,6655,5290,29851,8503,3458,1437,2353,4690,5894,5588,919,9020,959,917,3567,1493,4792,5062,3558,3265,5535,5530,10000,4790,5604,56924,920,8915,1739,3937,3586	CDC42,PIK3R2,AKT1,IL4,PIK3R1,KRAS,IKBKB,NFKBIB,VAV2,PDCD1,GRAP2,PAK5,CBL,ITK,CDK4,AKT2,JUN,CD28,TNF,SOS2,PIK3CA,ICOS,PIK3R3,IFNG,CSF2,FOS,NCK1,RAF1,PRKCQ,CD247,MAP3K14,CD40LG,CD3G,IL5,CTLA4,NFKBIA,PAK2,IL2,HRAS,PPP3R2,PPP3CA,AKT3,NFKB1,MAP2K1,PAK6,CD4,BCL10,DLG1,LCP2,IL10
hsa04660	T cell receptor signaling pathway	0.00152011952127233	-6.48896631479931	102	50	0.0203004466098254	2463	7161	5290,7124,6655,940,8503,29851,9402,208,3725,3702,1019,57144,867,3551,5133,7410,4793,3565,207,5296,998,3845,5295,1739,3937,8915,920,3586,4790,10000,5530,56924,5604,9020,917,959,5588,919,5894,4690,5535,3558,3265,4792,5062,1493,3567,3458,2353,1437	PIK3CA,TNF,SOS2,CD28,PIK3R3,ICOS,GRAP2,AKT2,JUN,ITK,CDK4,PAK5,CBL,IKBKB,PDCD1,VAV2,NFKBIB,IL4,AKT1,PIK3R2,CDC42,KRAS,PIK3R1,DLG1,LCP2,BCL10,CD4,IL10,NFKB1,AKT3,PPP3CA,PAK6,MAP2K1,MAP3K14,CD3G,CD40LG,PRKCQ,CD247,RAF1,NCK1,PPP3R2,IL2,HRAS,NFKBIA,PAK2,CTLA4,IL5,IFNG,FOS,CSF2
ko05212	Pancreatic cancer	0.00152645392360923	-6.48480793058212	64	34	0.0138043036946813	2463	7161	7043,7042,1021,5295,3845,9459,5296,998,7157,4088,5898,207,5899,4089,5602,598,7422,3551,3716,595,5925,5894,1019,208,6772,5604,10000,4790,7048,5880,8503,4087,5290,572	TGFB3,TGFB2,CDK6,PIK3R1,KRAS,ARHGEF6,PIK3R2,CDC42,TP53,SMAD3,RALA,AKT1,RALB,SMAD4,MAPK10,BCL2L1,VEGFA,IKBKB,JAK1,CCND1,RB1,RAF1,CDK4,AKT2,STAT1,MAP2K1,AKT3,NFKB1,TGFBR2,RAC2,PIK3R3,SMAD2,PIK3CA,BAD
hsa05212	Pancreatic cancer	0.00152645392360923	-6.48480793058212	64	34	0.0138043036946813	2463	7161	4088,5898,207,9459,7157,5296,998,3845,7042,5295,1021,7043,5925,595,5894,5602,598,3716,3551,7422,5899,4089,4790,7048,10000,208,5604,6772,1019,5290,4087,572,5880,8503	SMAD3,RALA,AKT1,ARHGEF6,TP53,PIK3R2,CDC42,KRAS,TGFB2,PIK3R1,CDK6,TGFB3,RB1,CCND1,RAF1,MAPK10,BCL2L1,JAK1,IKBKB,VEGFA,RALB,SMAD4,NFKB1,TGFBR2,AKT3,AKT2,MAP2K1,STAT1,CDK4,PIK3CA,SMAD2,BAD,RAC2,PIK3R3
hsa05211	Renal cell carcinoma	0.00152645392360923	-6.48480793058212	64	34	0.0138043036946813	2463	7161	10000,112398,6513,57144,201163,208,56924,3725,5604,5290,6655,8453,112399,5908,8503,5296,998,6921,4233,207,7043,5295,7042,3845,1387,1399,5781,7422,5894,5062,5906,2033,3265,2549	AKT3,EGLN2,SLC2A1,PAK5,FLCN,AKT2,PAK6,JUN,MAP2K1,PIK3CA,SOS2,CUL2,EGLN3,RAP1B,PIK3R3,PIK3R2,CDC42,ELOC,MET,AKT1,TGFB3,PIK3R1,TGFB2,KRAS,CREBBP,CRKL,PTPN11,VEGFA,RAF1,PAK2,RAP1A,EP300,HRAS,GAB1
ko05211	Renal cell carcinoma	0.00152645392360923	-6.48480793058212	64	34	0.0138043036946813	2463	7161	5604,56924,208,3725,201163,57144,6513,112398,10000,8503,5908,112399,6655,8453,5290,3845,5295,7043,7042,207,4233,6921,5296,998,3265,2549,2033,5906,5062,5894,7422,1387,1399,5781	MAP2K1,PAK6,AKT2,JUN,FLCN,PAK5,SLC2A1,EGLN2,AKT3,PIK3R3,RAP1B,EGLN3,SOS2,CUL2,PIK3CA,KRAS,PIK3R1,TGFB3,TGFB2,AKT1,MET,ELOC,PIK3R2,CDC42,HRAS,GAB1,EP300,RAP1A,PAK2,RAF1,VEGFA,CREBBP,CRKL,PTPN11
hsa05016	Huntington's disease	0.00162226691516478	-6.42393077753953	187	84	0.0341047503045067	2463	7161	10975,4713,27089,4694,1387,148327,498,4720,6648,1339,516,6667,23236,5433,5330,5441,125965,1175,7384,4728,84701,83544,4711,2876,55967,4697,581,5468,1349,5431,291,10476,4722,6391,539,1742,10488,4706,7416,55081,4714,4726,1351,51164,4729,4712,160,1537,292,7388,4716,2033,83447,10126,5432,1346,5435,1327,7157,1173,4698,2776,1345,1385,5436,506,513,170712,1340,6390,7385,10105,7417,4718,9377,522,25942,4695,514,518,6647,5438,4710,515	UQCR11,NDUFB7,UQCRQ,NDUFA1,CREBBP,CREB3L4,ATP5F1A,NDUFS2,SOD2,COX6A2,ATP5MC1,SP1,PLCB1,POLR2D,PLCB2,POLR2L,COX6B2,AP2S1,UQCRC1,NDUFS8,COX4I2,DNAL1,NDUFB5,GPX1,NDUFA12,NDUFA4,BAX,PPARG,COX7B,POLR2B,SLC25A4,ATP5PD,NDUFS3,SDHC,ATP5PO,DLG4,CREB3,NDUFAB1,VDAC1,IFT57,NDUFB8,NDUFS6,COX8A,DCTN4,NDUFV2,NDUFB6,AP2A1,CYC1,SLC25A5,UQCRH,NDUFB10,EP300,SLC25A31,DNAL4,POLR2C,COX7A1,POLR2F,COX4I1,TP53,AP2M1,NDUFA5,GNAQ,COX6C,CREB1,POLR2G,ATP5F1B,ATP5F1D,COX7B2,COX6B1,SDHB,UQCRC2,PPIF,VDAC2,NDUFC2,COX5A,ATP5PF,SIN3A,NDUFA2,ATP5F1E,ATP5MC3,SOD1,POLR2I,NDUFB4,ATP5PB
ko05016	Huntington's disease	0.00162226691516478	-6.42393077753953	187	84	0.0341047503045067	2463	7161	170712,1340,7385,6390,9377,4718,7417,10105,25942,522,6647,518,514,4695,4710,515,5438,160,4712,4729,51164,292,7388,1537,2033,4716,10126,83447,5435,1346,5432,4698,2776,1173,1327,7157,506,5436,1345,1385,513,4711,83544,55967,4697,581,2876,5468,1349,291,5431,539,1742,10488,6391,4722,10476,55081,4706,7416,4726,1351,4714,4713,10975,148327,498,1387,27089,4694,6667,1339,6648,516,4720,23236,5330,5433,7384,1175,125965,5441,4728,84701	COX7B2,COX6B1,UQCRC2,SDHB,COX5A,NDUFC2,VDAC2,PPIF,SIN3A,ATP5PF,SOD1,ATP5MC3,ATP5F1E,NDUFA2,NDUFB4,ATP5PB,POLR2I,AP2A1,NDUFB6,NDUFV2,DCTN4,SLC25A5,UQCRH,CYC1,EP300,NDUFB10,DNAL4,SLC25A31,POLR2F,COX7A1,POLR2C,NDUFA5,GNAQ,AP2M1,COX4I1,TP53,ATP5F1B,POLR2G,COX6C,CREB1,ATP5F1D,NDUFB5,DNAL1,NDUFA12,NDUFA4,BAX,GPX1,PPARG,COX7B,SLC25A4,POLR2B,ATP5PO,DLG4,CREB3,SDHC,NDUFS3,ATP5PD,IFT57,NDUFAB1,VDAC1,NDUFS6,COX8A,NDUFB8,NDUFB7,UQCR11,CREB3L4,ATP5F1A,CREBBP,UQCRQ,NDUFA1,SP1,COX6A2,SOD2,ATP5MC1,NDUFS2,PLCB1,PLCB2,POLR2D,UQCRC1,AP2S1,COX6B2,POLR2L,NDUFS8,COX4I2
hsa_M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum	0.00214445750751504	-6.14486866883875	13	10	0.00406008932196508	2463	7161	9200,201562,83401,79071,79993,6785,51495,64834,9524,401494	HACD1,HACD2,ELOVL3,ELOVL6,ELOVL7,ELOVL4,HACD3,ELOVL1,TECR,HACD4
M00415	Fatty acid biosynthesis, elongation, endoplasmic reticulum	0.00214445750751504	-6.14486866883875	13	10	0.00406008932196508	2463	7161	79071,79993,6785,51495,64834,9524,401494,9200,201562,83401	ELOVL6,ELOVL7,ELOVL4,HACD3,ELOVL1,TECR,HACD4,HACD1,HACD2,ELOVL3
hsa04630	Jak-STAT signaling pathway	0.00238459570518197	-6.03872568465821	156	71	0.0288266341859521	2463	7161	3458,2690,3953,1437,53833,5894,3596,3716,3440,1154,5008,9655,8554,3265,3592,3558,56832,3572,2033,3567,51561,3561,4609,3446,3456,10000,6773,4170,8835,122809,3569,3586,3601,2688,3562,3559,207,3565,3717,6778,5296,3952,5295,10379,9021,3454,595,316,598,1387,5781,3459,3593,6776,3574,3600,1026,6772,208,2056,6655,5290,3447,1442,59067,896,8503,50616,5617,1271,3560	IFNG,GHR,LEPR,CSF2,IL20RB,RAF1,IL13,JAK1,IFNA2,CISH,OSM,SOCS5,PIAS1,HRAS,IL12A,IL2,IFNK,IL6ST,EP300,IL5,IL23A,IL2RG,MYC,IFNA10,IFNB1,AKT3,STAT2,MCL1,SOCS2,SOCS4,IL6,IL10,IL15RA,GH1,IL3,IL2RA,AKT1,IL4,JAK2,STAT6,PIK3R2,LEP,PIK3R1,IRF9,SOCS3,IFNAR1,CCND1,AOX1,BCL2L1,CREBBP,PTPN11,IFNGR1,IL12B,STAT5A,IL7,IL15,CDKN1A,STAT1,AKT2,EPO,SOS2,PIK3CA,IFNA13,CSH1,IL21,CCND3,PIK3R3,IL22,PRL,CNTFR,IL2RB
ko04630	Jak-STAT signaling pathway	0.00238459570518197	-6.03872568465821	156	71	0.0288266341859521	2463	7161	3454,595,598,316,5781,1387,3459,3593,3562,3559,207,3565,3717,5296,6778,3952,5295,10379,9021,6655,2056,5290,3447,1442,59067,896,8503,50616,5617,1271,3560,6776,3574,3600,1026,6772,208,53833,5894,3596,3440,3716,1154,5008,9655,8554,3265,3592,3558,56832,3572,2033,3567,51561,3458,2690,3953,1437,122809,8835,3569,3601,3586,2688,3561,4609,3446,3456,10000,6773,4170	IFNAR1,CCND1,BCL2L1,AOX1,PTPN11,CREBBP,IFNGR1,IL12B,IL3,IL2RA,AKT1,IL4,JAK2,PIK3R2,STAT6,LEP,PIK3R1,IRF9,SOCS3,SOS2,EPO,PIK3CA,IFNA13,CSH1,IL21,CCND3,PIK3R3,IL22,PRL,CNTFR,IL2RB,STAT5A,IL7,IL15,CDKN1A,STAT1,AKT2,IL20RB,RAF1,IL13,IFNA2,JAK1,CISH,OSM,SOCS5,PIAS1,HRAS,IL12A,IL2,IFNK,IL6ST,EP300,IL5,IL23A,IFNG,GHR,LEPR,CSF2,SOCS4,SOCS2,IL6,IL15RA,IL10,GH1,IL2RG,MYC,IFNA10,IFNB1,AKT3,STAT2,MCL1
M00158	F-type ATPase, eukaryotes	0.00238983768144984	-6.03652983105646	15	11	0.00446609825416159	2463	7161	10632,498,516,522,10476,539,514,518,506,513,515	ATP5MG,ATP5F1A,ATP5MC1,ATP5PF,ATP5PD,ATP5PO,ATP5F1E,ATP5MC3,ATP5F1B,ATP5F1D,ATP5PB
hsa_M00158	F-type ATPase, eukaryotes	0.00238983768144984	-6.03652983105646	15	11	0.00446609825416159	2463	7161	498,539,10632,10476,522,515,513,506,518,514,516	ATP5F1A,ATP5PO,ATP5MG,ATP5PD,ATP5PF,ATP5PB,ATP5F1D,ATP5F1B,ATP5MC3,ATP5F1E,ATP5MC1
hsa_M00154	Cytochrome c oxidase	0.0025318646101831	-5.97879924762153	21	14	0.00568412505075112	2463	7161	84701,1351,1352,1353,1345,10063,1327,125965,1346,1349,9377,1339,1340,170712	COX4I2,COX8A,COX10,COX11,COX6C,COX17,COX4I1,COX6B2,COX7A1,COX7B,COX5A,COX6A2,COX6B1,COX7B2
M00154	Cytochrome c oxidase	0.0025318646101831	-5.97879924762153	21	14	0.00568412505075112	2463	7161	1340,170712,1349,9377,1339,1327,125965,1346,1353,1352,1351,84701,10063,1345	COX6B1,COX7B2,COX7B,COX5A,COX6A2,COX4I1,COX6B2,COX7A1,COX11,COX10,COX8A,COX4I2,COX17,COX6C
M00341	Proteasome, 19S regulatory particle (PA700)	0.00255802903787704	-5.96851822410061	19	13	0.00527811611855461	2463	7161	5704,5718,5700,5707,7979,5713,5709,11047,5710,5705,5702,9861,10213	PSMC4,PSMD12,PSMC1,PSMD1,SEM1,PSMD7,PSMD3,ADRM1,PSMD4,PSMC5,PSMC3,PSMD6,PSMD14
hsa_M00341	Proteasome, 19S regulatory particle (PA700)	0.00255802903787704	-5.96851822410061	19	13	0.00527811611855461	2463	7161	9861,10213,5705,5702,11047,5710,5709,5713,5704,7979,5700,5707,5718	PSMD6,PSMD14,PSMC5,PSMC3,ADRM1,PSMD4,PSMD3,PSMD7,PSMC4,SEM1,PSMC1,PSMD1,PSMD12
ko04060	Cytokine-cytokine receptor interaction	0.00264529580771921	-5.93497238335831	270	115	0.0466910272025985	2463	7161	5617,3553,3447,659,7124,9547,6368,6347,7424,3574,3600,2921,658,6362,3593,6366,356,729230,1233,7043,3577,1524,3562,3556,2688,6361,6370,8995,958,3586,3552,2833,6352,3604,3456,3561,355,6356,7852,7048,6363,1236,3592,3558,4049,56832,3440,388372,3596,1232,959,1437,7042,60401,6375,3627,3458,2919,1271,3560,112744,50616,59067,657,2056,6387,3815,1234,4055,8764,8742,3459,90,4050,3606,3454,10850,10663,3952,6373,3559,3565,7133,10563,3601,3569,56477,57007,1230,6355,6369,9966,6346,8743,4283,6364,3446,944,7850,3567,51561,3572,7422,5008,3576,1235,53833,6376,80301,3953,91,2690,8741,4233,6348	PRL,IL1B,IFNA13,BMPR2,TNF,CXCL14,CCL23,CCL2,VEGFC,IL7,IL15,CXCL3,BMPR1B,CCL18,IL12B,CCL21,FASLG,CCR2,CCR4,TGFB3,CXCR1,CX3CR1,IL3,IL1RAP,GH1,CCL17,CCL25,TNFSF18,CD40,IL10,IL1A,CXCR3,CCL5,TNFRSF9,IFNB1,IL2RG,FAS,CCL11,CXCR4,TGFBR2,CCL19,CCR7,IL12A,IL2,LTA,IFNK,IFNA2,CCL4L1,IL13,CCR3,CD40LG,CSF2,TGFB2,EDA2R,XCL1,CXCL10,IFNG,CXCL1,CNTFR,IL2RB,IL17F,IL22,IL21,BMPR1A,EPO,CXCL12,KIT,CCR5,LTBR,TNFRSF14,TNFSF12,IFNGR1,ACVR1,LTB,IL18,IFNAR1,CCL27,CXCR6,LEP,CXCL11,IL2RA,IL4,TNFRSF1B,CXCL13,IL15RA,IL6,CCL28,ACKR3,CCR1,CCL8,CCL24,TNFSF15,CCL1,TNFSF10,CXCL9,CCL20,IFNA10,TNFSF8,IL1R2,IL5,IL23A,IL6ST,VEGFA,OSM,CXCL8,CCR6,IL20RB,CX3CL1,PLEKHO2,LEPR,ACVR1B,GHR,TNFSF13,MET,CCL3
hsa04060	Cytokine-cytokine receptor interaction	0.00264529580771921	-5.93497238335831	270	115	0.0466910272025985	2463	7161	7852,6356,7048,355,3561,3456,3604,6352,2833,3552,3586,958,8995,6370,6361,2688,3556,2919,3458,3627,6375,60401,1437,7042,959,3596,1232,388372,3440,56832,4049,3592,1236,3558,6363,2921,3600,3574,7424,6347,6368,9547,7124,659,3447,3553,5617,3562,1524,3577,7043,1233,729230,6366,356,3593,6362,658,944,3446,6364,4283,8743,6346,9966,6369,6355,1230,56477,57007,3569,10563,3601,7133,4233,6348,8741,2690,91,3953,80301,6376,3576,1235,53833,5008,7422,3572,51561,7850,3567,8742,8764,4055,3815,1234,6387,2056,657,59067,50616,112744,3560,1271,3565,3559,6373,3952,10663,10850,3454,3606,4050,90,3459	CXCR4,CCL11,TGFBR2,FAS,IL2RG,IFNB1,TNFRSF9,CCL5,CXCR3,IL1A,IL10,CD40,TNFSF18,CCL25,CCL17,GH1,IL1RAP,CXCL1,IFNG,CXCL10,XCL1,EDA2R,CSF2,TGFB2,CD40LG,IL13,CCR3,CCL4L1,IFNA2,IFNK,LTA,IL12A,CCR7,IL2,CCL19,CXCL3,IL15,IL7,VEGFC,CCL2,CCL23,CXCL14,TNF,BMPR2,IFNA13,IL1B,PRL,IL3,CX3CR1,CXCR1,TGFB3,CCR4,CCR2,CCL21,FASLG,IL12B,CCL18,BMPR1B,TNFSF8,IFNA10,CCL20,CXCL9,TNFSF10,CCL1,TNFSF15,CCL24,CCL8,CCR1,CCL28,ACKR3,IL6,CXCL13,IL15RA,TNFRSF1B,MET,CCL3,TNFSF13,GHR,ACVR1B,LEPR,PLEKHO2,CX3CL1,CXCL8,CCR6,IL20RB,OSM,VEGFA,IL6ST,IL23A,IL1R2,IL5,TNFSF12,TNFRSF14,LTBR,KIT,CCR5,CXCL12,EPO,BMPR1A,IL21,IL22,IL17F,IL2RB,CNTFR,IL4,IL2RA,CXCL11,LEP,CXCR6,CCL27,IFNAR1,IL18,LTB,ACVR1,IFNGR1
hsa04110	Cell cycle	0.00271276527343576	-5.909786768239	124	58	0.0235485180673975	2463	7161	9232,890,595,9184,4173,1387,4193,5001,1874,4088,5885,7043,246184,2810,8317,7709,8881,896,7529,5111,7532,1031,991,983,1026,4085,1022,1019,51343,5925,4172,4175,1032,4089,2033,494551,29945,7157,7534,1021,7042,1647,1027,51529,4087,10459,25847,23594,902,7533,6500,4609,891,29882,8697,7029,4616,10912	PTTG1,CCNA2,CCND1,BUB3,MCM4,CREBBP,MDM2,ORC5,E2F4,SMAD3,RAD21,TGFB3,CDC26,SFN,CDC7,ZBTB17,CDC16,CCND3,YWHAB,PCNA,YWHAG,CDKN2C,CDC20,CDK1,CDKN1A,MAD2L1,CDK7,CDK4,FZR1,RB1,MCM3,MCM6,CDKN2D,SMAD4,EP300,WEE2,ANAPC4,TP53,YWHAZ,CDK6,TGFB2,GADD45A,CDKN1B,ANAPC11,SMAD2,MAD2L2,ANAPC13,ORC6,CCNH,YWHAH,SKP1,MYC,CCNB1,ANAPC2,CDC23,TFDP2,GADD45B,GADD45G
ko04110	Cell cycle	0.00271276527343576	-5.909786768239	124	58	0.0235485180673975	2463	7161	991,1026,983,51343,1019,1022,4085,8317,896,8881,7709,7532,1031,5111,7529,4088,1874,5885,2810,246184,7043,595,890,9184,9232,4193,1387,4173,5001,4609,891,6500,8697,29882,7029,10912,4616,4087,51529,1027,10459,7533,902,23594,25847,7534,7157,1647,7042,1021,5925,4175,4172,4089,2033,1032,29945,494551	CDC20,CDKN1A,CDK1,FZR1,CDK4,CDK7,MAD2L1,CDC7,CCND3,CDC16,ZBTB17,YWHAG,CDKN2C,PCNA,YWHAB,SMAD3,E2F4,RAD21,SFN,CDC26,TGFB3,CCND1,CCNA2,BUB3,PTTG1,MDM2,CREBBP,MCM4,ORC5,MYC,CCNB1,SKP1,CDC23,ANAPC2,TFDP2,GADD45G,GADD45B,SMAD2,ANAPC11,CDKN1B,MAD2L2,YWHAH,CCNH,ORC6,ANAPC13,YWHAZ,TP53,GADD45A,TGFB2,CDK6,RB1,MCM6,MCM3,SMAD4,EP300,CDKN2D,ANAPC4,WEE2
hsa05010	Alzheimer's disease	0.00313782009478479	-5.76422695748599	165	74	0.0300446609825416	2463	7161	3028,4311,4716,5535,7388,1537,23621,55851,4729,4712,5664,513,1345,506,1327,51806,4698,2776,823,3416,1346,4718,9377,6390,7385,57142,1340,5663,170712,4710,515,4695,514,518,5530,522,355,824,23236,23385,4720,2597,1339,516,4694,27089,8883,498,10975,1020,4713,84701,51107,4728,125965,7384,5330,1349,3553,55967,4697,7124,572,8851,4711,4714,100506742,1351,4726,4706,10476,4722,6391,539	HSD17B10,MME,NDUFB10,PPP3R2,UQCRH,CYC1,BACE1,PSENEN,NDUFV2,NDUFB6,PSEN2,ATP5F1D,COX6C,ATP5F1B,COX4I1,CALML5,NDUFA5,GNAQ,CAPN1,IDE,COX7A1,NDUFC2,COX5A,SDHB,UQCRC2,RTN4,COX6B1,PSEN1,COX7B2,NDUFB4,ATP5PB,NDUFA2,ATP5F1E,ATP5MC3,PPP3CA,ATP5PF,FAS,CAPN2,PLCB1,NCSTN,NDUFS2,GAPDH,COX6A2,ATP5MC1,NDUFA1,UQCRQ,NAE1,ATP5F1A,UQCR11,CDK5,NDUFB7,COX4I2,APH1A,NDUFS8,COX6B2,UQCRC1,PLCB2,COX7B,IL1B,NDUFA12,NDUFA4,TNF,BAD,CDK5R1,NDUFB5,NDUFB8,CASP12,COX8A,NDUFS6,NDUFAB1,ATP5PD,NDUFS3,SDHC,ATP5PO
ko05010	Alzheimer's disease	0.00313782009478479	-5.76422695748599	165	74	0.0300446609825416	2463	7161	7385,6390,9377,4718,5663,170712,1340,57142,518,514,4695,4710,515,824,355,522,5530,5535,4716,4311,3028,4712,4729,55851,23621,1537,7388,506,1345,513,5664,1346,3416,2776,4698,823,51806,1327,1349,4711,8851,7124,572,55967,4697,3553,4706,1351,4726,100506742,4714,539,6391,4722,10476,516,1339,2597,23385,4720,23236,4713,1020,10975,498,8883,27089,4694,4728,51107,84701,5330,7384,125965	UQCRC2,SDHB,COX5A,NDUFC2,PSEN1,COX7B2,COX6B1,RTN4,ATP5MC3,ATP5F1E,NDUFA2,NDUFB4,ATP5PB,CAPN2,FAS,ATP5PF,PPP3CA,PPP3R2,NDUFB10,MME,HSD17B10,NDUFB6,NDUFV2,PSENEN,BACE1,CYC1,UQCRH,ATP5F1B,COX6C,ATP5F1D,PSEN2,COX7A1,IDE,GNAQ,NDUFA5,CAPN1,CALML5,COX4I1,COX7B,NDUFB5,CDK5R1,TNF,BAD,NDUFA12,NDUFA4,IL1B,NDUFAB1,COX8A,NDUFS6,CASP12,NDUFB8,ATP5PO,SDHC,NDUFS3,ATP5PD,ATP5MC1,COX6A2,GAPDH,NCSTN,NDUFS2,PLCB1,NDUFB7,CDK5,UQCR11,ATP5F1A,NAE1,UQCRQ,NDUFA1,NDUFS8,APH1A,COX4I2,PLCB2,UQCRC1,COX6B2
ko05218	Melanoma	0.00365431144808135	-5.61184758982518	69	35	0.0142103126268778	2463	7161	5296,8823,8822,7157,4233,207,5295,1021,27006,3845,5728,4193,3480,595,5925,5894,2258,2248,3265,1026,10000,2257,1019,4286,208,8074,5604,3479,5290,2252,2255,572,2246,2260,8503	PIK3R2,FGF16,FGF17,TP53,MET,AKT1,PIK3R1,CDK6,FGF22,KRAS,PTEN,MDM2,IGF1R,CCND1,RB1,RAF1,FGF13,FGF3,HRAS,CDKN1A,AKT3,FGF12,CDK4,MITF,AKT2,FGF23,MAP2K1,IGF1,PIK3CA,FGF7,FGF10,BAD,FGF1,FGFR1,PIK3R3
hsa05218	Melanoma	0.00365431144808135	-5.61184758982518	69	35	0.0142103126268778	2463	7161	2248,3265,2258,5925,595,5894,4193,3480,5728,3845,27006,1021,5295,4233,207,8822,5296,7157,8823,2260,8503,2246,5290,2252,572,2255,3479,8074,208,5604,1019,2257,4286,10000,1026	FGF3,HRAS,FGF13,RB1,CCND1,RAF1,MDM2,IGF1R,PTEN,KRAS,FGF22,CDK6,PIK3R1,MET,AKT1,FGF17,PIK3R2,TP53,FGF16,FGFR1,PIK3R3,FGF1,PIK3CA,FGF7,BAD,FGF10,IGF1,FGF23,AKT2,MAP2K1,CDK4,FGF12,MITF,AKT3,CDKN1A
M00351	Spliceosome, U1-snRNP	0.00423437757748905	-5.46451893275639	10	8	0.00324807145757207	2463	7161	6625,6635,6633,6632,6634,6626,6637,6628	SNRNP70,SNRPE,SNRPD2,SNRPD1,SNRPD3,SNRPA,SNRPG,SNRPB
hsa_M00351	Spliceosome, U1-snRNP	0.00423437757748905	-5.46451893275639	10	8	0.00324807145757207	2463	7161	6634,6637,6626,6628,6625,6635,6632,6633	SNRPD3,SNRPG,SNRPA,SNRPB,SNRNP70,SNRPE,SNRPD1,SNRPD2
hsa04725	Cholinergic synapse	0.00527908974954601	-5.24400159204517	112	52	0.0211124644742184	2463	7161	1133,2788,2767,1385,1141,2353,2775,59345,109,2776,3265,51764,1128,5567,468,1131,108,5604,2782,10000,2785,5578,55970,1139,2790,5294,1132,3759,3845,2793,2773,5295,3717,5330,207,5296,2784,23236,148327,56479,208,2791,54331,2771,5579,10488,818,2787,8503,43,5290,3760	CHRM5,GNG7,GNA11,CREB1,CHRNB2,FOS,GNAO1,GNB4,ADCY3,GNAQ,HRAS,GNG13,CHRM1,PRKACB,ATF4,CHRM3,ADCY2,MAP2K1,GNB1,AKT3,GNG3,PRKCA,GNG12,CHRNA7,GNG10,PIK3CG,CHRM4,KCNJ2,KRAS,GNGT2,GNAI3,PIK3R1,JAK2,PLCB2,AKT1,PIK3R2,GNB3,PLCB1,CREB3L4,KCNQ5,AKT2,GNG11,GNG2,GNAI2,PRKCB,CREB3,CAMK2G,GNG5,PIK3R3,ACHE,PIK3CA,KCNJ3
hsa03030	DNA replication	0.00728427536465716	-4.92203731378724	36	20	0.00812017864393017	2463	7161	57804,56655,2237,23649,5985,5983,5982,6742,6118,84153,5111,6119,5984,5425,246243,4172,5558,54107,4173,4175	POLD4,POLE4,FEN1,POLA2,RFC5,RFC3,RFC2,SSBP1,RPA2,RNASEH2C,PCNA,RPA3,RFC4,POLD2,RNASEH1,MCM3,PRIM2,POLE3,MCM4,MCM6
ko03030	DNA replication	0.00728427536465716	-4.92203731378724	36	20	0.00812017864393017	2463	7161	5984,5111,6119,84153,4175,246243,5425,4172,54107,5558,4173,2237,23649,57804,56655,5983,5982,6742,6118,5985	RFC4,PCNA,RPA3,RNASEH2C,MCM6,RNASEH1,POLD2,MCM3,POLE3,PRIM2,MCM4,FEN1,POLA2,POLD4,POLE4,RFC3,RFC2,SSBP1,RPA2,RFC5
ko00062	Fatty acid elongation	0.00768447699861755	-4.86855295913922	25	15	0.00609013398294762	2463	7161	51495,64834,79993,5538,3030,83401,51102,9200,9524,401494,6785,79071,3033,10449,201562	HACD3,ELOVL1,ELOVL7,PPT1,HADHA,ELOVL3,MECR,HACD1,TECR,HACD4,ELOVL4,ELOVL6,HADH,ACAA2,HACD2
hsa00062	Fatty acid elongation	0.00768447699861755	-4.86855295913922	25	15	0.00609013398294762	2463	7161	83401,3030,9200,51102,51495,64834,5538,79993,10449,201562,6785,401494,9524,3033,79071	ELOVL3,HADHA,HACD1,MECR,HACD3,ELOVL1,PPT1,ELOVL7,ACAA2,HACD2,ELOVL4,HACD4,TECR,HADH,ELOVL6
hsa04141	Protein processing in endoplasmic reticulum	0.00793426518929078	-4.83656453303583	165	72	0.0292326431181486	2463	7161	578,9373,7184,824,6500,7095,1649,30001,10130,7323,3703,10961,10905,55829,7327,6048,6184,9695,10273,23471,3320,3300,823,4780,9532,7321,3326,80267,6396,29927,10484,10956,23193,7494,468,23480,5887,5610,6747,84447,1965,55968,7991,100506742,51128,1410,3312,10113,3309,581,80331,64215,27248,7353,55176,2923,6745,5611,55741,1603,3998,54431,6746,79139,258010,10952,11231,7186,5602,80700,811,51009	BAK1,PLAA,HSP90B1,CAPN2,SKP1,SEC62,DDIT3,ERO1A,PDIA6,UBE2D3,STT3A,ERP29,MAN1A2,SELENOS,UBE2G2,RNF5,RPN1,EDEM1,STUB1,TRAM1,HSP90AA1,DNAJB2,CAPN1,NFE2L2,BAG2,UBE2D1,HSP90AB1,EDEM3,SEC13,SEC61A1,SEC23A,OS9,GANAB,XBP1,ATF4,SEC61G,RAD23B,EIF2AK2,SSR3,SYVN1,EIF2S1,NSFL1C,TUSC3,CASP12,SAR1B,CRYAB,HSPA8,PREB,HSPA5,BAX,DNAJC5,DNAJC1,ERLEC1,UFD1,SEC61A2,PDIA3,SSR1,DNAJC3,EDEM2,DAD1,LMAN1,DNAJC10,SSR2,DERL1,SVIP,SEC61B,SEC63,TRAF2,MAPK10,UBXN6,CALR,DERL2
ko04141	Protein processing in endoplasmic reticulum	0.00793426518929078	-4.83656453303583	165	72	0.0292326431181486	2463	7161	80331,3309,581,10113,3312,7353,27248,64215,1965,84447,1410,100506742,51128,7991,55968,7186,5602,11231,51009,811,80700,1603,55741,5611,6745,2923,55176,10952,79139,258010,6746,3998,54431,6184,55829,7327,6048,10905,10961,3300,23471,3320,9695,10273,30001,7095,1649,6500,9373,7184,578,824,3703,7323,10130,468,23480,23193,7494,29927,10484,10956,6747,5887,5610,823,6396,3326,80267,9532,4780,7321	DNAJC5,HSPA5,BAX,PREB,HSPA8,UFD1,ERLEC1,DNAJC1,EIF2S1,SYVN1,CRYAB,CASP12,SAR1B,TUSC3,NSFL1C,TRAF2,MAPK10,SEC63,DERL2,CALR,UBXN6,DAD1,EDEM2,DNAJC3,SSR1,PDIA3,SEC61A2,SEC61B,DERL1,SVIP,SSR2,LMAN1,DNAJC10,RPN1,SELENOS,UBE2G2,RNF5,MAN1A2,ERP29,DNAJB2,TRAM1,HSP90AA1,EDEM1,STUB1,ERO1A,SEC62,DDIT3,SKP1,PLAA,HSP90B1,BAK1,CAPN2,STT3A,UBE2D3,PDIA6,ATF4,SEC61G,GANAB,XBP1,SEC61A1,SEC23A,OS9,SSR3,RAD23B,EIF2AK2,CAPN1,SEC13,HSP90AB1,EDEM3,BAG2,NFE2L2,UBE2D1
hsa_M00396	Lsm 2-8 complex	0.00814519075257267	-4.81032761761088	7	6	0.00243605359317905	2463	7161	57819,23658,51691,27258,11157,25804	LSM2,LSM5,LSM8,LSM3,LSM6,LSM4
hsa_M00398	Sm core complex	0.00814519075257267	-4.81032761761088	7	6	0.00243605359317905	2463	7161	6632,6633,6635,6637,6634,6628	SNRPD1,SNRPD2,SNRPE,SNRPG,SNRPD3,SNRPB
M00398	Sm core complex	0.00814519075257267	-4.81032761761088	7	6	0.00243605359317905	2463	7161	6634,6637,6635,6628,6632,6633	SNRPD3,SNRPG,SNRPE,SNRPB,SNRPD1,SNRPD2
M00396	Lsm 2-8 complex	0.00814519075257267	-4.81032761761088	7	6	0.00243605359317905	2463	7161	57819,23658,11157,25804,27258,51691	LSM2,LSM5,LSM6,LSM4,LSM3,LSM8
hsa04068	FoxO signaling pathway	0.00850572336926984	-4.76701600451474	132	59	0.023954526999594	2463	7161	5894,2911,3480,6794,1032,4089,2033,3265,1647,1454,604,7042,4087,5564,1027,6789,3569,3586,26260,9456,80854,891,7048,10000,116986,92579,8743,5604,11345,10912,4616,595,114907,5602,8698,1387,4193,3551,356,6648,4088,207,5296,5728,3845,5295,7043,9454,5290,23710,6655,5571,3479,8503,11337,5106,1026,5896,208	RAF1,GRM1,IGF1R,STK11,CDKN2D,SMAD4,EP300,HRAS,GADD45A,CSNK1E,BCL6,TGFB2,SMAD2,PRKAB1,CDKN1B,STK4,IL6,IL10,FBXO25,HOMER1,SETD7,CCNB1,TGFBR2,AKT3,AGAP2,G6PC3,TNFSF10,MAP2K1,GABARAPL2,GADD45G,GADD45B,CCND1,FBXO32,MAPK10,S1PR4,CREBBP,MDM2,IKBKB,FASLG,SOD2,SMAD3,AKT1,PIK3R2,PTEN,KRAS,PIK3R1,TGFB3,HOMER3,PIK3CA,GABARAPL1,SOS2,PRKAG1,IGF1,PIK3R3,GABARAP,PCK2,CDKN1A,RAG1,AKT2
hsa00020	Citrate cycle (TCA cycle)	0.0100874295806982	-4.5964652262582	30	17	0.00690215184734064	2463	7161	5091,6391,3420,1743,8801,3418,5106,48,5162,4190,50,5160,3417,55753,1737,6390,3419	PC,SDHC,IDH3B,DLST,SUCLG2,IDH2,PCK2,ACO1,PDHB,MDH1,ACO2,PDHA1,IDH1,OGDHL,DLAT,SDHB,IDH3A
ko00020	Citrate cycle (TCA cycle)	0.0100874295806982	-4.5964652262582	30	17	0.00690215184734064	2463	7161	5160,3417,6390,3419,55753,1737,8801,3418,5106,48,5091,6391,3420,1743,4190,50,5162	PDHA1,IDH1,SDHB,IDH3A,OGDHL,DLAT,SUCLG2,IDH2,PCK2,ACO1,PC,SDHC,IDH3B,DLST,MDH1,ACO2,PDHB
hsa_M00686	Toll-like receptor signaling	0.0107972430568179	-4.5284644499564	15	10	0.00406008932196508	2463	7161	4790,51135,7099,3551,4615,23118,7097,7189,4792,10454	NFKB1,IRAK4,TLR4,IKBKB,MYD88,TAB2,TLR2,TRAF6,NFKBIA,TAB1
M00686	Toll-like receptor signaling	0.0107972430568179	-4.5284644499564	15	10	0.00406008932196508	2463	7161	4790,51135,7099,4615,3551,23118,7097,7189,4792,10454	NFKB1,IRAK4,TLR4,MYD88,IKBKB,TAB2,TLR2,TRAF6,NFKBIA,TAB1
ko04668	TNF signaling pathway	0.0112466067214603	-4.48768882058869	108	49	0.0198944376776289	2463	7161	3553,5290,6347,7124,5608,23118,8503,10488,3600,3726,2921,3725,208,7424,5602,148327,329,7186,3551,4318,7185,5606,5296,207,9021,5295,4323,3569,10454,7133,10000,4790,7128,355,6364,6352,5604,3383,468,9020,4792,4049,8986,2919,3627,2353,6376,1437,1385	IL1B,PIK3CA,CCL2,TNF,MAP2K6,TAB2,PIK3R3,CREB3,IL15,JUNB,CXCL3,JUN,AKT2,VEGFC,MAPK10,CREB3L4,BIRC2,TRAF2,IKBKB,MMP9,TRAF1,MAP2K3,PIK3R2,AKT1,SOCS3,PIK3R1,MMP14,IL6,TAB1,TNFRSF1B,AKT3,NFKB1,TNFAIP3,FAS,CCL20,CCL5,MAP2K1,ICAM1,ATF4,MAP3K14,NFKBIA,LTA,RPS6KA4,CXCL1,CXCL10,FOS,CX3CL1,CSF2,CREB1
hsa04668	TNF signaling pathway	0.0112466067214603	-4.48768882058869	108	49	0.0198944376776289	2463	7161	8503,23118,5608,7124,5290,6347,3553,3725,7424,208,2921,3726,3600,10488,5606,7185,4318,3551,5602,148327,329,7186,4323,5295,9021,207,5296,7133,10454,3569,5604,6352,355,6364,4790,7128,10000,8986,4049,4792,9020,468,3383,1385,1437,2353,6376,3627,2919	PIK3R3,TAB2,MAP2K6,TNF,PIK3CA,CCL2,IL1B,JUN,VEGFC,AKT2,CXCL3,JUNB,IL15,CREB3,MAP2K3,TRAF1,MMP9,IKBKB,MAPK10,CREB3L4,BIRC2,TRAF2,MMP14,PIK3R1,SOCS3,AKT1,PIK3R2,TNFRSF1B,TAB1,IL6,MAP2K1,CCL5,FAS,CCL20,NFKB1,TNFAIP3,AKT3,RPS6KA4,LTA,NFKBIA,MAP3K14,ATF4,ICAM1,CREB1,CSF2,FOS,CX3CL1,CXCL10,CXCL1
hsa04727	GABAergic synapse	0.011533917329431	-4.46246325136871	88	41	0.0166463662200568	2463	7161	2550,2566,2554,5567,2562,51764,6714,2784,10243,2572,5334,6538,109,59345,10991,2773,2775,2793,140679,2788,54407,23710,2790,2561,55970,2787,5578,2785,2782,81539,2752,5579,11337,2771,11345,6529,54331,2791,108,2555,66008	GABBR1,GABRG2,GABRA1,PRKACB,GABRB3,GNG13,SRC,GNB3,GPHN,GAD2,PLCL1,SLC6A11,ADCY3,GNB4,SLC38A3,GNAI3,GNAO1,GNGT2,SLC32A1,GNG7,SLC38A2,GABARAPL1,GNG10,GABRB2,GNG12,GNG5,PRKCA,GNG3,GNB1,SLC38A1,GLUL,PRKCB,GABARAP,GNAI2,GABARAPL2,SLC6A1,GNG2,GNG11,ADCY2,GABRA2,TRAK2
ko04727	GABAergic synapse	0.011533917329431	-4.46246325136871	88	41	0.0166463662200568	2463	7161	2550,2566,2554,5567,2562,51764,6714,10243,2784,2572,5334,6538,59345,109,10991,2773,2775,2793,140679,2788,23710,54407,2790,2561,55970,2787,5578,2785,2782,81539,2752,5579,11337,2771,11345,6529,54331,2791,2555,108,66008	GABBR1,GABRG2,GABRA1,PRKACB,GABRB3,GNG13,SRC,GPHN,GNB3,GAD2,PLCL1,SLC6A11,GNB4,ADCY3,SLC38A3,GNAI3,GNAO1,GNGT2,SLC32A1,GNG7,GABARAPL1,SLC38A2,GNG10,GABRB2,GNG12,GNG5,PRKCA,GNG3,GNB1,SLC38A1,GLUL,PRKCB,GABARAP,GNAI2,GABARAPL2,SLC6A1,GNG2,GNG11,GABRA2,ADCY2,TRAK2
hsa05144	Malaria	0.0118946517851885	-4.4316664097046	49	25	0.0101502233049127	2463	7161	6383,7043,7042,3043,948,4233,3458,4615,3586,54106,958,7097,3592,7059,6347,959,3039,3576,7099,7124,3606,3383,3569,975,3553	SDC2,TGFB3,TGFB2,HBB,CD36,MET,IFNG,MYD88,IL10,TLR9,CD40,TLR2,IL12A,THBS3,CCL2,CD40LG,HBA1,CXCL8,TLR4,TNF,IL18,ICAM1,IL6,CD81,IL1B
ko05144	Malaria	0.0118946517851885	-4.4316664097046	49	25	0.0101502233049127	2463	7161	3592,3383,3606,7099,3576,959,7043,7042,3458,4233,7059,7097,54106,958,3586,975,3553,3569,7124,3039,6347,6383,4615,3043,948	IL12A,ICAM1,IL18,TLR4,CXCL8,CD40LG,TGFB3,TGFB2,IFNG,MET,THBS3,TLR2,TLR9,CD40,IL10,CD81,IL1B,IL6,TNF,HBA1,CCL2,SDC2,MYD88,HBB,CD36
M00401	Sec61 complex	0.0139723169517869	-4.27067726751193	4	4	0.00162403572878603	2463	7161	10952,23480,29927,55176	SEC61B,SEC61G,SEC61A1,SEC61A2
hsa_M00401	Sec61 complex	0.0139723169517869	-4.27067726751193	4	4	0.00162403572878603	2463	7161	10952,23480,29927,55176	SEC61B,SEC61G,SEC61A1,SEC61A2
hsa04933	AGE-RAGE signaling pathway in diabetic complications	0.0141656482311317	-4.25693538387123	99	45	0.0182704019488429	2463	7161	7048,5579,6776,4790,10000,6772,208,7424,3725,1019,7124,1278,1027,5290,6347,4087,3552,3553,3569,581,8503,5578,1958,207,3717,4088,7056,5330,5296,998,3845,5295,7043,7042,3576,595,7422,1281,3383,5602,177,3265,4089,5581,23236	TGFBR2,PRKCB,STAT5A,NFKB1,AKT3,STAT1,AKT2,VEGFC,JUN,CDK4,TNF,COL1A2,CDKN1B,PIK3CA,CCL2,SMAD2,IL1A,IL1B,IL6,BAX,PIK3R3,PRKCA,EGR1,AKT1,JAK2,SMAD3,THBD,PLCB2,PIK3R2,CDC42,KRAS,PIK3R1,TGFB3,TGFB2,CXCL8,CCND1,VEGFA,COL3A1,ICAM1,MAPK10,AGER,HRAS,SMAD4,PRKCE,PLCB1
ko04933	AGE-RAGE signaling pathway in diabetic complications	0.0141656482311317	-4.25693538387123	99	45	0.0182704019488429	2463	7161	5579,6776,1019,6772,7424,208,3725,3553,581,7124,5290,6347,8503,998,5296,207,4088,3717,5330,5295,7043,3845,1281,5602,595,5581,23236,177,10000,7048,4790,3552,3569,1027,1278,4087,5578,1958,7056,7042,7422,3383,3576,3265,4089	PRKCB,STAT5A,CDK4,STAT1,VEGFC,AKT2,JUN,IL1B,BAX,TNF,PIK3CA,CCL2,PIK3R3,CDC42,PIK3R2,AKT1,SMAD3,JAK2,PLCB2,PIK3R1,TGFB3,KRAS,COL3A1,MAPK10,CCND1,PRKCE,PLCB1,AGER,AKT3,TGFBR2,NFKB1,IL1A,IL6,CDKN1B,COL1A2,SMAD2,PRKCA,EGR1,THBD,TGFB2,VEGFA,ICAM1,CXCL8,HRAS,SMAD4
ko04064	NF-kappa B signaling pathway	0.0143176355436902	-4.24626324674682	94	43	0.0174583840844499	2463	7161	4792,7329,6363,114609,4049,3383,959,9020,3576,5588,388372,6850,353376,10454,958,1460,8915,1457,4616,7189,4615,4790,7128,7185,598,7186,329,4050,3551,6366,7099,23643,929,51135,597,23118,3553,6387,7124,4055,23586,148022,5579	NFKBIA,UBE2I,CCL19,TIRAP,LTA,ICAM1,CD40LG,MAP3K14,CXCL8,PRKCQ,CCL4L1,SYK,TICAM2,TAB1,CD40,CSNK2B,BCL10,CSNK2A1,GADD45B,TRAF6,MYD88,NFKB1,TNFAIP3,TRAF1,BCL2L1,TRAF2,BIRC2,LTB,IKBKB,CCL21,TLR4,LY96,CD14,IRAK4,BCL2A1,TAB2,IL1B,CXCL12,TNF,LTBR,RIGI,TICAM1,PRKCB
hsa04064	NF-kappa B signaling pathway	0.0143176355436902	-4.24626324674682	94	43	0.0174583840844499	2463	7161	10454,597,23118,958,1460,8915,3553,6387,7124,1457,4616,4055,7189,4615,23586,4790,148022,7128,5579,7185,7329,6363,4792,114609,4049,598,329,3383,7186,4050,3551,6366,959,9020,3576,388372,5588,7099,23643,6850,929,353376,51135	TAB1,BCL2A1,TAB2,CD40,CSNK2B,BCL10,IL1B,CXCL12,TNF,CSNK2A1,GADD45B,LTBR,TRAF6,MYD88,RIGI,NFKB1,TICAM1,TNFAIP3,PRKCB,TRAF1,UBE2I,CCL19,NFKBIA,TIRAP,LTA,BCL2L1,BIRC2,ICAM1,TRAF2,LTB,IKBKB,CCL21,CD40LG,MAP3K14,CXCL8,CCL4L1,PRKCQ,TLR4,LY96,SYK,CD14,TICAM2,IRAK4
hsa05323	Rheumatoid arthritis	0.0144207453657073	-4.23908745874503	89	41	0.0166463662200568	2463	7161	534,2353,7042,7043,1437,1513,941,8741,6348,2919,54,284,3458,51561,1493,4050,3383,523,9550,7422,3606,7099,3576,51382,6352,3725,533,3600,6364,8992,7097,940,90423,3552,3553,3569,528,6387,6347,7124,942	ATP6V1G2,FOS,TGFB2,TGFB3,CSF2,CTSK,CD80,TNFSF13,CCL3,CXCL1,ACP5,ANGPT1,IFNG,IL23A,CTLA4,LTB,ICAM1,ATP6V1A,ATP6V1G1,VEGFA,IL18,TLR4,CXCL8,ATP6V1D,CCL5,JUN,ATP6V0B,IL15,CCL20,ATP6V0E1,TLR2,CD28,ATP6V1E2,IL1A,IL1B,IL6,ATP6V1C1,CXCL12,CCL2,TNF,CD86
ko05323	Rheumatoid arthritis	0.0144207453657073	-4.23908745874503	89	41	0.0166463662200568	2463	7161	6352,3725,533,51382,6364,3600,8992,7097,528,6387,6347,7124,942,90423,940,3552,3553,3569,1513,534,2353,1437,7042,7043,2919,6348,284,54,3458,941,8741,51561,1493,7099,3606,3576,3383,4050,523,9550,7422	CCL5,JUN,ATP6V0B,ATP6V1D,CCL20,IL15,ATP6V0E1,TLR2,ATP6V1C1,CXCL12,CCL2,TNF,CD86,ATP6V1E2,CD28,IL1A,IL1B,IL6,CTSK,ATP6V1G2,FOS,CSF2,TGFB2,TGFB3,CXCL1,CCL3,ANGPT1,ACP5,IFNG,CD80,TNFSF13,IL23A,CTLA4,TLR4,IL18,CXCL8,ICAM1,LTB,ATP6V1A,ATP6V1G1,VEGFA
ko05215	Prostate cancer	0.0161304433566735	-4.1270469007582	87	40	0.0162403572878603	2463	7161	354,10000,1026,10488,7184,4790,1499,5604,208,4824,2950,3479,6655,572,1027,367,5290,3320,8503,2260,5296,7157,207,5295,3326,1385,3845,5728,3551,3480,1387,4193,468,148327,5894,595,5925,4792,3265,2033	KLK3,AKT3,CDKN1A,CREB3,HSP90B1,NFKB1,CTNNB1,MAP2K1,AKT2,NKX3-1,GSTP1,IGF1,SOS2,BAD,CDKN1B,AR,PIK3CA,HSP90AA1,PIK3R3,FGFR1,PIK3R2,TP53,AKT1,PIK3R1,HSP90AB1,CREB1,KRAS,PTEN,IKBKB,IGF1R,CREBBP,MDM2,ATF4,CREB3L4,RAF1,CCND1,RB1,NFKBIA,HRAS,EP300
hsa05215	Prostate cancer	0.0161304433566735	-4.1270469007582	87	40	0.0162403572878603	2463	7161	5290,6655,572,367,1027,3479,2260,3320,8503,7184,4790,10000,1026,10488,354,208,2950,4824,1499,5604,595,5925,5894,4193,468,1387,148327,3480,3551,2033,3265,4792,207,5296,7157,1385,5728,3845,3326,5295	PIK3CA,SOS2,BAD,AR,CDKN1B,IGF1,FGFR1,HSP90AA1,PIK3R3,HSP90B1,NFKB1,AKT3,CDKN1A,CREB3,KLK3,AKT2,GSTP1,NKX3-1,CTNNB1,MAP2K1,CCND1,RB1,RAF1,MDM2,ATF4,CREBBP,CREB3L4,IGF1R,IKBKB,EP300,HRAS,NFKBIA,AKT1,PIK3R2,TP53,CREB1,PTEN,KRAS,HSP90AB1,PIK3R1
hsa05200	Pathways in cancer	0.0168279036134892	-4.08471684101633	395	156	0.0633373934226553	2463	7161	3265,8323,1856,51764,9475,4792,332,5567,5371,3655,2767,7042,3685,3326,59345,7157,2776,9170,5578,10342,10161,8453,367,1027,2790,10235,1499,1487,7189,3913,355,7048,7852,4609,7184,2785,8322,2784,2956,1495,7185,2258,595,3551,356,5602,598,1399,4193,1387,27006,4149,7043,2773,207,5330,4088,5898,5296,3728,1902,8503,7480,2787,112399,7704,6655,2252,6093,3479,8074,4824,7424,867,2771,7472,5734,1164,861,3673,7476,2033,4089,5899,3576,5894,5925,5732,3480,3716,7422,64399,2788,1021,2353,7976,109,4233,6921,8823,3320,55970,2260,6258,4087,1909,3569,6789,1613,5604,108,6513,2257,4790,354,2782,10000,2248,25780,23236,1163,4318,329,7186,1496,3845,5728,7170,5295,2793,998,8822,5468,5880,2246,572,2255,5731,5290,6387,581,1612,6772,2950,3725,208,4286,3815,54331,1019,2791,51684,6776,5579,112398,1026	HRAS,FZD6,DVL2,GNG13,ROCK2,NFKBIA,BIRC5,PRKACB,PML,ITGA6,GNA11,TGFB2,ITGAV,HSP90AB1,GNB4,TP53,GNAQ,LPAR2,PRKCA,TFG,LPAR6,CUL2,AR,CDKN1B,GNG10,RASGRP2,CTNNB1,CTBP1,TRAF6,LAMB2,FAS,TGFBR2,CXCR4,MYC,HSP90B1,GNG3,FZD4,GNB3,MSH6,CTNNA1,TRAF1,FGF13,CCND1,IKBKB,FASLG,MAPK10,BCL2L1,CRKL,MDM2,CREBBP,FGF22,MAX,TGFB3,GNAI3,AKT1,PLCB2,SMAD3,RALA,PIK3R2,JUP,LPAR1,PIK3R3,WNT10B,GNG5,EGLN3,ZBTB16,SOS2,FGF7,ROCK1,IGF1,FGF23,NKX3-1,VEGFC,CBL,GNAI2,WNT2,PTGER4,CKS2,RUNX1,ITGA2,WNT7A,EP300,SMAD4,RALB,CXCL8,RAF1,RB1,PTGER2,IGF1R,JAK1,VEGFA,HHIP,GNG7,CDK6,FOS,FZD3,ADCY3,MET,ELOC,FGF16,HSP90AA1,GNG12,FGFR1,RXRG,SMAD2,EDNRA,IL6,STK4,DAPK3,MAP2K1,ADCY2,SLC2A1,FGF12,NFKB1,KLK3,GNB1,AKT3,FGF3,RASGRP3,PLCB1,CKS1B,MMP9,BIRC2,TRAF2,CTNNA2,KRAS,PTEN,TPM3,PIK3R1,GNGT2,CDC42,FGF17,PPARG,RAC2,FGF1,BAD,FGF10,PTGER1,PIK3CA,CXCL12,BAX,DAPK1,STAT1,GSTP1,JUN,AKT2,MITF,KIT,GNG2,CDK4,GNG11,SUFU,STAT5A,PRKCB,EGLN2,CDKN1A
hsa05134	Legionellosis	0.0169337146802978	-4.07844869282936	55	27	0.0109622411693057	2463	7161	2921,4790,4615,375,1937,51128,7124,3329,3312,1915,81876,3553,7100,3569,7097,29108,2919,1195,929,3606,7099,3576,9554,5861,3593,3592,4792	CXCL3,NFKB1,MYD88,ARF1,EEF1G,SAR1B,TNF,HSPD1,HSPA8,EEF1A1,RAB1B,IL1B,TLR5,IL6,TLR2,PYCARD,CXCL1,CLK1,CD14,IL18,TLR4,CXCL8,SEC22B,RAB1A,IL12B,IL12A,NFKBIA
ko05134	Legionellosis	0.0169337146802978	-4.07844869282936	55	27	0.0109622411693057	2463	7161	929,2919,1195,3592,3593,4792,7099,3606,3576,9554,5861,1937,375,51128,2921,4790,4615,7097,29108,7124,3329,3312,3553,81876,1915,7100,3569	CD14,CXCL1,CLK1,IL12A,IL12B,NFKBIA,TLR4,IL18,CXCL8,SEC22B,RAB1A,EEF1G,ARF1,SAR1B,CXCL3,NFKB1,MYD88,TLR2,PYCARD,TNF,HSPD1,HSPA8,IL1B,RAB1B,EEF1A1,TLR5,IL6
hsa05321	Inflammatory bowel disease (IBD)	0.017857267072119	-4.02534473472068	65	31	0.0125862768980918	2463	7161	3567,51561,3459,3592,3593,3558,3606,7099,3596,7042,7043,6778,3458,3565,4088,112744,7097,50616,3586,3569,7100,59067,3553,3552,7124,4087,50943,6772,3725,3561,4790	IL5,IL23A,IFNGR1,IL12A,IL12B,IL2,IL18,TLR4,IL13,TGFB2,TGFB3,STAT6,IFNG,IL4,SMAD3,IL17F,TLR2,IL22,IL10,IL6,TLR5,IL21,IL1B,IL1A,TNF,SMAD2,FOXP3,STAT1,JUN,IL2RG,NFKB1
ko05321	Inflammatory bowel disease (IBD)	0.017857267072119	-4.02534473472068	65	31	0.0125862768980918	2463	7161	6772,3725,3561,4790,112744,7097,50616,3586,7100,3569,3553,59067,3552,7124,4087,50943,7043,7042,6778,3458,4088,3565,3567,51561,3459,3593,3592,3558,3606,7099,3596	STAT1,JUN,IL2RG,NFKB1,IL17F,TLR2,IL22,IL10,TLR5,IL6,IL1B,IL21,IL1A,TNF,SMAD2,FOXP3,TGFB3,TGFB2,STAT6,IFNG,SMAD3,IL4,IL5,IL23A,IFNGR1,IL12B,IL12A,IL2,IL18,TLR4,IL13
hsa04917	Prolactin signaling pathway	0.0180739440863352	-4.01328393110375	70	33	0.0133982947624848	2463	7161	9021,2353,5295,2001,53358,3845,2100,5296,3717,207,6464,6714,3265,9655,5602,1154,595,5894,208,6772,5604,10000,1586,3972,6776,4790,3659,5617,8503,5290,6655,122809,8835	SOCS3,FOS,PIK3R1,ELF5,SHC3,KRAS,ESR2,PIK3R2,JAK2,AKT1,SHC1,SRC,HRAS,SOCS5,MAPK10,CISH,CCND1,RAF1,AKT2,STAT1,MAP2K1,AKT3,CYP17A1,LHB,STAT5A,NFKB1,IRF1,PRL,PIK3R3,PIK3CA,SOS2,SOCS4,SOCS2
ko04917	Prolactin signaling pathway	0.0180739440863352	-4.01328393110375	70	33	0.0133982947624848	2463	7161	5290,122809,8835,6655,5617,8503,3659,6776,4790,10000,1586,3972,208,6772,5604,595,5894,9655,5602,1154,6714,3265,6464,3717,207,2100,5296,2001,53358,3845,9021,2353,5295	PIK3CA,SOCS4,SOCS2,SOS2,PRL,PIK3R3,IRF1,STAT5A,NFKB1,AKT3,CYP17A1,LHB,AKT2,STAT1,MAP2K1,CCND1,RAF1,SOCS5,MAPK10,CISH,SRC,HRAS,SHC1,JAK2,AKT1,ESR2,PIK3R2,ELF5,SHC3,KRAS,SOCS3,FOS,PIK3R1
ko04915	Estrogen signaling pathway	0.0193376360692245	-3.94570202656087	98	44	0.0178643930166464	2463	7161	5894,5567,4318,2550,468,2911,148327,3265,6714,2288,6667,6464,23236,207,109,5330,5296,51806,2776,1839,2100,53358,1385,3845,2773,5295,3326,2353,2775,6655,5290,3312,3760,8503,3320,7184,10000,10488,5604,208,108,3725,2771,4988	RAF1,PRKACB,MMP9,GABBR1,ATF4,GRM1,CREB3L4,HRAS,SRC,FKBP4,SP1,SHC1,PLCB1,AKT1,ADCY3,PLCB2,PIK3R2,CALML5,GNAQ,HBEGF,ESR2,SHC3,CREB1,KRAS,GNAI3,PIK3R1,HSP90AB1,FOS,GNAO1,SOS2,PIK3CA,HSPA8,KCNJ3,PIK3R3,HSP90AA1,HSP90B1,AKT3,CREB3,MAP2K1,AKT2,ADCY2,JUN,GNAI2,OPRM1
hsa04915	Estrogen signaling pathway	0.0193376360692245	-3.94570202656087	98	44	0.0178643930166464	2463	7161	6464,23236,2288,6667,3265,6714,468,148327,2911,2550,4318,5894,5567,3326,2353,2775,2773,5295,1385,53358,3845,1839,2776,2100,5296,51806,109,5330,207,3320,8503,3760,5290,3312,6655,4988,2771,208,108,3725,5604,10000,10488,7184	SHC1,PLCB1,FKBP4,SP1,HRAS,SRC,ATF4,CREB3L4,GRM1,GABBR1,MMP9,RAF1,PRKACB,HSP90AB1,FOS,GNAO1,GNAI3,PIK3R1,CREB1,SHC3,KRAS,HBEGF,GNAQ,ESR2,PIK3R2,CALML5,ADCY3,PLCB2,AKT1,HSP90AA1,PIK3R3,KCNJ3,PIK3CA,HSPA8,SOS2,OPRM1,GNAI2,AKT2,ADCY2,JUN,MAP2K1,AKT3,CREB3,HSP90B1
hsa04919	Thyroid hormone signaling pathway	0.019596061349391	-3.93242668450082	116	51	0.0207064555420219	2463	7161	6772,208,5350,5579,8503,117247,572,5290,8841,481,483,23389,3845,5295,1735,207,5330,5296,90390,23236,29079,476,595,9882,1387,4193,5604,1499,6513,4609,25942,478,10000,6258,6009,5578,60,1734,9442,477,9440,3685,1733,4853,7157,6714,3265,2033,5208,5567,5894	STAT1,AKT2,PLN,PRKCB,PIK3R3,SLC16A10,BAD,PIK3CA,HDAC3,ATP1B1,ATP1B3,MED13L,KRAS,PIK3R1,DIO3,AKT1,PLCB2,PIK3R2,MED30,PLCB1,MED4,ATP1A1,CCND1,TBC1D4,CREBBP,MDM2,MAP2K1,CTNNB1,SLC2A1,MYC,SIN3A,ATP1A3,AKT3,RXRG,RHEB,PRKCA,ACTB,DIO2,MED27,ATP1A2,MED17,ITGAV,DIO1,NOTCH2,TP53,SRC,HRAS,EP300,PFKFB2,PRKACB,RAF1
hsa_M00109	C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone	0.020558877822388	-3.8844624205079	6	5	0.00203004466098254	2463	7161	1585,1586,3290,1584,1589	CYP11B2,CYP17A1,HSD11B1,CYP11B1,CYP21A2
M00109	C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone	0.020558877822388	-3.8844624205079	6	5	0.00203004466098254	2463	7161	1586,3290,1585,1584,1589	CYP17A1,HSD11B1,CYP11B2,CYP11B1,CYP21A2
hsa04120	Ubiquitin mediated proteolysis	0.0205806694355335	-3.88340302065369	137	59	0.023954526999594	2463	7161	329,4193,7320,22954,9886,9040,11060,7337,55284,23291,55070,7328,27339,246184,9021,8452,64326,4591,8881,140739,991,84447,55958,7334,7325,7319,867,51343,5371,57154,8554,55294,26091,7332,7329,29945,6921,672,3093,7321,10477,51529,8453,11059,27338,7327,25847,10273,8916,9616,6500,8697,29882,6477,7189,7323,10075,9039,25898	BIRC2,MDM2,UBE2B,TRIM32,RHOBTB1,UBE2M,WWP2,UBE3A,UBE2W,FBXW11,DET1,UBE2H,PRPF19,CDC26,SOCS3,CUL3,COP1,TRIM37,CDC16,UBE2F,CDC20,SYVN1,KLHL9,UBE2N,UBE2E2,UBE2A,CBL,FZR1,PML,SMURF1,PIAS1,FBXW7,HERC4,UBE2L3,UBE2I,ANAPC4,ELOC,BRCA1,UBE2K,UBE2D1,UBE2E3,ANAPC11,CUL2,WWP1,UBE2S,UBE2G2,ANAPC13,STUB1,HERC3,RNF7,SKP1,CDC23,ANAPC2,SIAH1,TRAF6,UBE2D3,HUWE1,UBA3,RCHY1
ko04120	Ubiquitin mediated proteolysis	0.0205806694355335	-3.88340302065369	137	59	0.023954526999594	2463	7161	8452,64326,4591,8881,140739,991,7334,55958,84447,7325,7319,867,51343,7320,4193,329,22954,9886,7337,9040,11060,23291,55284,55070,7328,27339,246184,9021,8453,51529,11059,7327,27338,25847,10273,8916,9616,6500,29882,6477,8697,7189,7323,25898,9039,10075,57154,5371,8554,55294,7332,26091,29945,7329,672,6921,10477,7321,3093	CUL3,COP1,TRIM37,CDC16,UBE2F,CDC20,UBE2N,KLHL9,SYVN1,UBE2E2,UBE2A,CBL,FZR1,UBE2B,MDM2,BIRC2,TRIM32,RHOBTB1,UBE3A,UBE2M,WWP2,FBXW11,UBE2W,DET1,UBE2H,PRPF19,CDC26,SOCS3,CUL2,ANAPC11,WWP1,UBE2G2,UBE2S,ANAPC13,STUB1,HERC3,RNF7,SKP1,ANAPC2,SIAH1,CDC23,TRAF6,UBE2D3,RCHY1,UBA3,HUWE1,SMURF1,PML,PIAS1,FBXW7,UBE2L3,HERC4,ANAPC4,UBE2I,BRCA1,ELOC,UBE2E3,UBE2D1,UBE2K
ko00533	Glycosaminoglycan biosynthesis - keratan sulfate	0.0215160568102195	-3.83895579420376	14	9	0.00365408038976857	2463	7161	10678,8534,2530,8703,2683,8702,6482,6483,9435	B3GNT2,CHST1,FUT8,B4GALT3,B4GALT1,B4GALT4,ST3GAL1,ST3GAL2,CHST2
M00389	APC/C complex	0.0215160568102195	-3.83895579420376	14	9	0.00365408038976857	2463	7161	25847,246184,29945,51343,991,51529,29882,8881,8697	ANAPC13,CDC26,ANAPC4,FZR1,CDC20,ANAPC11,ANAPC2,CDC16,CDC23
hsa_M00389	APC/C complex	0.0215160568102195	-3.83895579420376	14	9	0.00365408038976857	2463	7161	51343,29945,246184,25847,8697,8881,29882,51529,991	FZR1,ANAPC4,CDC26,ANAPC13,CDC23,CDC16,ANAPC2,ANAPC11,CDC20
hsa00533	Glycosaminoglycan biosynthesis - keratan sulfate	0.0215160568102195	-3.83895579420376	14	9	0.00365408038976857	2463	7161	2683,8703,8702,9435,6483,6482,8534,10678,2530	B4GALT1,B4GALT3,B4GALT4,CHST2,ST3GAL2,ST3GAL1,CHST1,B3GNT2,FUT8
ko04140	Autophagy - animal	0.0219763633722724	-3.81778779536626	127	55	0.022330491270808	2463	7161	29982,64422,3476,55014,10325,58476,3265,1508,3480,6794,5516,5588,5894,5567,11345,7189,5604,10000,3920,22808,60673,22800,6009,3146,8673,1613,1509,5295,9342,3845,5728,5296,207,115201,51100,598,5602,8678,83452,81671,208,55054,84938,9821,79065,10670,11337,1965,8503,1612,5290,572,23710,10533,54541	NRBF2,ATG3,IGBP1,STX17,RRAGB,TP53INP2,HRAS,CTSB,IGF1R,STK11,PPP2CB,PRKCQ,RAF1,PRKACB,GABARAPL2,TRAF6,MAP2K1,AKT3,LAMP2,MRAS,ATG101,RRAS2,RHEB,HMGB1,VAMP8,DAPK3,CTSD,PIK3R1,SNAP29,KRAS,PTEN,PIK3R2,AKT1,ATG4A,SH3GLB1,BCL2L1,MAPK10,BECN1,RAB33B,VMP1,AKT2,ATG16L1,ATG4C,RB1CC1,ATG9A,RRAGA,GABARAP,EIF2S1,PIK3R3,DAPK1,PIK3CA,BAD,GABARAPL1,ATG7,DDIT4
hsa04140	Autophagy - animal	0.0219763633722724	-3.81778779536626	127	55	0.022330491270808	2463	7161	3845,5728,9342,5295,1509,207,5296,115201,83452,5602,598,51100,8678,55054,208,84938,81671,11337,10670,1965,9821,79065,8503,5290,54541,10533,23710,572,1612,55014,3476,64422,29982,10325,3265,58476,5516,5567,5588,5894,3480,6794,1508,5604,7189,11345,3920,10000,6009,22800,3146,8673,22808,60673,1613	KRAS,PTEN,SNAP29,PIK3R1,CTSD,AKT1,PIK3R2,ATG4A,RAB33B,MAPK10,BCL2L1,SH3GLB1,BECN1,ATG16L1,AKT2,ATG4C,VMP1,GABARAP,RRAGA,EIF2S1,RB1CC1,ATG9A,PIK3R3,PIK3CA,DDIT4,ATG7,GABARAPL1,BAD,DAPK1,STX17,IGBP1,ATG3,NRBF2,RRAGB,HRAS,TP53INP2,PPP2CB,PRKACB,PRKCQ,RAF1,IGF1R,STK11,CTSB,MAP2K1,TRAF6,GABARAPL2,LAMP2,AKT3,RHEB,RRAS2,HMGB1,VAMP8,MRAS,ATG101,DAPK3
hsa05168	Herpes simplex infection	0.0228644767084218	-3.77817080827345	185	77	0.0312626877791311	2463	7161	356,5500,3551,7186,1387,5781,2969,5602,6881,3454,4793,7185,6427,3593,3459,3717,10379,9021,4938,3553,3447,6432,6429,7124,6347,3665,7097,6041,23118,983,23586,29110,29997,3600,1965,148022,27097,6772,8764,3725,3716,3440,5819,5371,10929,4792,3661,3592,4049,2033,5610,7157,29915,3458,2353,7098,57506,6426,5501,3569,10454,10189,1460,54106,4615,3190,3456,6500,355,3446,4790,1457,64135,7189,6773,9569,6352	FASLG,PPP1CB,IKBKB,TRAF2,CREBBP,PTPN11,GTF2I,MAPK10,TAF10,IFNAR1,NFKBIB,TRAF1,SRSF2,IL12B,IFNGR1,JAK2,IRF9,SOCS3,OAS1,IL1B,IFNA13,SRSF7,SRSF4,TNF,CCL2,IRF7,TLR2,RNASEL,TAB2,CDK1,RIGI,TBK1,NOP53,IL15,EIF2S1,TICAM1,TAF5L,STAT1,TNFRSF14,JUN,JAK1,IFNA2,NECTIN2,PML,SRSF8,NFKBIA,IRF3,IL12A,LTA,EP300,EIF2AK2,TP53,HCFC2,IFNG,FOS,TLR3,MAVS,SRSF1,PPP1CC,IL6,TAB1,ALYREF,CSNK2B,TLR9,MYD88,HNRNPK,IFNB1,SKP1,FAS,IFNA10,NFKB1,CSNK2A1,IFIH1,TRAF6,STAT2,GTF2IRD1,CCL5
ko05168	Herpes simplex infection	0.0228644767084218	-3.77817080827345	185	77	0.0312626877791311	2463	7161	148022,1965,29997,29110,3600,23586,983,3725,8764,6772,27097,6347,7124,6429,3553,3447,6432,6041,23118,7097,3665,3717,4938,9021,10379,6881,3454,5781,1387,7186,5602,2969,356,3551,5500,3593,3459,4793,6427,7185,3446,4790,6500,355,3190,3456,4615,6352,9569,6773,7189,64135,1457,3569,54106,1460,10454,10189,29915,3458,7157,6426,57506,7098,5501,2353,5371,5819,3440,3716,2033,4049,5610,3592,4792,3661,10929	TICAM1,EIF2S1,NOP53,TBK1,IL15,RIGI,CDK1,JUN,TNFRSF14,STAT1,TAF5L,CCL2,TNF,SRSF4,IL1B,IFNA13,SRSF7,RNASEL,TAB2,TLR2,IRF7,JAK2,OAS1,SOCS3,IRF9,TAF10,IFNAR1,PTPN11,CREBBP,TRAF2,MAPK10,GTF2I,FASLG,IKBKB,PPP1CB,IL12B,IFNGR1,NFKBIB,SRSF2,TRAF1,IFNA10,NFKB1,SKP1,FAS,HNRNPK,IFNB1,MYD88,CCL5,GTF2IRD1,STAT2,TRAF6,IFIH1,CSNK2A1,IL6,TLR9,CSNK2B,TAB1,ALYREF,HCFC2,IFNG,TP53,SRSF1,MAVS,TLR3,PPP1CC,FOS,PML,NECTIN2,IFNA2,JAK1,EP300,LTA,EIF2AK2,IL12A,NFKBIA,IRF3,SRSF8
hsa_M00010	Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate	0.0230731960448568	-3.76908367955364	8	6	0.00243605359317905	2463	7161	50,3417,3419,48,3418,3420	ACO2,IDH1,IDH3A,ACO1,IDH2,IDH3B
M00010	Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate	0.0230731960448568	-3.76908367955364	8	6	0.00243605359317905	2463	7161	3420,3417,3418,48,50,3419	IDH3B,IDH1,IDH2,ACO1,ACO2,IDH3A
hsa_M00680	TGF-beta signaling	0.0230731960448568	-3.76908367955364	8	6	0.00243605359317905	2463	7161	4089,7043,7042,7048,4088,4087	SMAD4,TGFB3,TGFB2,TGFBR2,SMAD3,SMAD2
M00680	TGF-beta signaling	0.0230731960448568	-3.76908367955364	8	6	0.00243605359317905	2463	7161	7043,7042,4089,7048,4088,4087	TGFB3,TGFB2,SMAD4,TGFBR2,SMAD3,SMAD2
hsa_M00406	TREX complex	0.0230731960448568	-3.76908367955364	8	6	0.00243605359317905	2463	7161	7919,57187,79228,10189,84321,9984	DDX39B,THOC2,THOC6,ALYREF,THOC3,THOC1
M00406	TREX complex	0.0230731960448568	-3.76908367955364	8	6	0.00243605359317905	2463	7161	79228,57187,7919,10189,84321,9984	THOC6,THOC2,DDX39B,ALYREF,THOC3,THOC1
ko05146	Amoebiasis	0.0240015089915991	-3.72963857596076	94	42	0.0170523751522534	2463	7161	23236,384,7850,5868,3593,3592,1281,5567,3576,7099,7043,5272,1437,7042,5295,5273,2767,929,9630,81,2776,5296,5330,2919,5878,3458,3586,1992,5578,8503,7097,3569,3553,5290,1278,7124,3315,912,3913,5269,4790,5579	PLCB1,ARG2,IL1R2,RAB5A,IL12B,IL12A,COL3A1,PRKACB,CXCL8,TLR4,TGFB3,SERPINB9,CSF2,TGFB2,PIK3R1,SERPINB10,GNA11,CD14,GNA14,ACTN4,GNAQ,PIK3R2,PLCB2,CXCL1,RAB5C,IFNG,IL10,SERPINB1,PRKCA,PIK3R3,TLR2,IL6,IL1B,PIK3CA,COL1A2,TNF,HSPB1,CD1D,LAMB2,SERPINB6,NFKB1,PRKCB
hsa05146	Amoebiasis	0.0240015089915991	-3.72963857596076	94	42	0.0170523751522534	2463	7161	7099,5567,3576,1281,3592,3593,5868,7850,23236,384,5878,3458,2919,5330,5296,2776,929,9630,81,2767,5272,7042,5295,1437,7043,5273,7124,3315,1278,5290,3553,3569,8503,7097,5578,3586,1992,5579,5269,4790,3913,912	TLR4,PRKACB,CXCL8,COL3A1,IL12A,IL12B,RAB5A,IL1R2,PLCB1,ARG2,RAB5C,IFNG,CXCL1,PLCB2,PIK3R2,GNAQ,CD14,GNA14,ACTN4,GNA11,SERPINB9,TGFB2,PIK3R1,CSF2,TGFB3,SERPINB10,TNF,HSPB1,COL1A2,PIK3CA,IL1B,IL6,PIK3R3,TLR2,PRKCA,IL10,SERPINB1,PRKCB,SERPINB6,NFKB1,LAMB2,CD1D
ko04920	Adipocytokine signaling pathway	0.0256552089902564	-3.66300864844106	69	32	0.0129922858302883	2463	7161	6258,7133,5564,7124,5571,79602,208,2182,6513,1375,948,4790,5106,10000,92579,4792,4793,51094,9370,5588,5781,7186,5465,5602,6794,3551,3953,3952,9021,4852,3717,207	RXRG,TNFRSF1B,PRKAB1,TNF,PRKAG1,ADIPOR2,AKT2,ACSL4,SLC2A1,CPT1B,CD36,NFKB1,PCK2,AKT3,G6PC3,NFKBIA,NFKBIB,ADIPOR1,ADIPOQ,PRKCQ,PTPN11,TRAF2,PPARA,MAPK10,STK11,IKBKB,LEPR,LEP,SOCS3,NPY,JAK2,AKT1
hsa04920	Adipocytokine signaling pathway	0.0256552089902564	-3.66300864844106	69	32	0.0129922858302883	2463	7161	208,6513,2182,5106,1375,948,4790,10000,92579,7133,6258,7124,5564,79602,5571,3952,3953,9021,207,3717,4852,4792,4793,51094,9370,5588,6794,3551,5465,7186,5781,5602	AKT2,SLC2A1,ACSL4,PCK2,CPT1B,CD36,NFKB1,AKT3,G6PC3,TNFRSF1B,RXRG,TNF,PRKAB1,ADIPOR2,PRKAG1,LEP,LEPR,SOCS3,AKT1,JAK2,NPY,NFKBIA,NFKBIB,ADIPOR1,ADIPOQ,PRKCQ,STK11,IKBKB,PPARA,TRAF2,PTPN11,MAPK10
ko05205	Proteoglycans in cancer	0.0297935286817528	-3.51346406738351	203	83	0.0336987413723102	2463	7161	4609,4478,4060,355,10000,406991,2002,1499,5604,2817,967,6385,4087,5578,22800,1975,2260,22808,60,4233,7976,27250,2017,7157,7078,406903,5501,7042,3685,3059,29102,5894,5567,7422,3480,8323,6714,3265,9475,5579,7476,1026,3693,3673,208,406902,6383,7472,867,4659,6093,5290,7124,6655,3479,117581,818,7480,858,3316,7097,8503,207,1839,998,5296,3845,5295,595,4318,857,7099,859,4193,5781,356,5500,1655,8322,3593,2549,7074,7410	MYC,MSN,LUM,FAS,AKT3,MIR21,ELK1,CTNNB1,MAP2K1,GPC1,CD63,SDC4,SMAD2,PRKCA,RRAS2,EIF4B,FGFR1,MRAS,ACTB,MET,FZD3,PDCD4,CTTN,TP53,TIMP3,MIR10B,PPP1CC,TGFB2,ITGAV,HCLS1,DROSHA,RAF1,PRKACB,VEGFA,IGF1R,FZD6,SRC,HRAS,ROCK2,PRKCB,WNT7A,CDKN1A,ITGB5,ITGA2,AKT2,MIR10A,SDC2,WNT2,CBL,PPP1R12A,ROCK1,PIK3CA,TNF,SOS2,IGF1,TWIST2,CAMK2G,WNT10B,CAV2,HSPB2,TLR2,PIK3R3,AKT1,HBEGF,CDC42,PIK3R2,KRAS,PIK3R1,CCND1,MMP9,CAV1,TLR4,CAV3,MDM2,PTPN11,FASLG,PPP1CB,DDX5,FZD4,IL12B,GAB1,TIAM1,VAV2
hsa05205	Proteoglycans in cancer	0.0297935286817528	-3.51346406738351	203	83	0.0336987413723102	2463	7161	818,7480,3316,8503,7097,858,3479,117581,5290,6093,4659,6655,7124,6383,867,7472,208,406902,3693,7476,1026,3673,5579,7410,2549,7074,8322,3593,5781,4193,1655,5500,356,857,595,4318,859,7099,5295,3845,1839,5296,998,207,22808,60,2260,1975,5578,22800,4087,967,2817,6385,2002,5604,1499,406991,10000,4609,4478,4060,355,9475,6714,3265,8323,3480,7422,29102,3059,5567,5894,3685,7042,406903,7078,5501,2017,27250,7157,4233,7976	CAMK2G,WNT10B,HSPB2,PIK3R3,TLR2,CAV2,IGF1,TWIST2,PIK3CA,ROCK1,PPP1R12A,SOS2,TNF,SDC2,CBL,WNT2,AKT2,MIR10A,ITGB5,WNT7A,CDKN1A,ITGA2,PRKCB,VAV2,GAB1,TIAM1,FZD4,IL12B,PTPN11,MDM2,DDX5,PPP1CB,FASLG,CAV1,CCND1,MMP9,CAV3,TLR4,PIK3R1,KRAS,HBEGF,PIK3R2,CDC42,AKT1,MRAS,ACTB,FGFR1,EIF4B,PRKCA,RRAS2,SMAD2,CD63,GPC1,SDC4,ELK1,MAP2K1,CTNNB1,MIR21,AKT3,MYC,MSN,LUM,FAS,ROCK2,SRC,HRAS,FZD6,IGF1R,VEGFA,DROSHA,HCLS1,PRKACB,RAF1,ITGAV,TGFB2,MIR10B,TIMP3,PPP1CC,CTTN,PDCD4,TP53,MET,FZD3
M00684	JAK-STAT signaling	0.0303072057977453	-3.49636977963324	19	11	0.00446609825416159	2463	7161	8835,122809,3716,1154,9655,6772,6773,9021,6776,3717,6778	SOCS2,SOCS4,JAK1,CISH,SOCS5,STAT1,STAT2,SOCS3,STAT5A,JAK2,STAT6
hsa_M00684	JAK-STAT signaling	0.0303072057977453	-3.49636977963324	19	11	0.00446609825416159	2463	7161	8835,122809,1154,3716,9655,6773,6772,9021,3717,6776,6778	SOCS2,SOCS4,CISH,JAK1,SOCS5,STAT2,STAT1,SOCS3,JAK2,STAT5A,STAT6
hsa04380	Osteoclast differentiation	0.0304228402108717	-3.49256162994555	129	55	0.022330491270808	2463	7161	3726,3725,208,6772,7305,4286,5290,7124,3553,23118,5608,5468,8503,207,5296,9021,5295,2355,10379,11027,2212,3454,5602,7186,2209,3551,3459,4790,7048,3456,10000,5530,5604,6773,7189,3937,10859,3552,11024,10454,11026,54,11006,3458,6850,1513,1385,2353,7042,2213,9020,8878,3716,5535,4792	JUNB,JUN,AKT2,STAT1,TYROBP,MITF,PIK3CA,TNF,IL1B,TAB2,MAP2K6,PPARG,PIK3R3,AKT1,PIK3R2,SOCS3,PIK3R1,FOSL2,IRF9,LILRA2,FCGR2A,IFNAR1,MAPK10,TRAF2,FCGR1A,IKBKB,IFNGR1,NFKB1,TGFBR2,IFNB1,AKT3,PPP3CA,MAP2K1,STAT2,TRAF6,LCP2,LILRB1,IL1A,LILRA1,TAB1,LILRA3,ACP5,LILRB4,IFNG,SYK,CTSK,CREB1,FOS,TGFB2,FCGR2B,MAP3K14,SQSTM1,JAK1,PPP3R2,NFKBIA
ko04380	Osteoclast differentiation	0.0304228402108717	-3.49256162994555	129	55	0.022330491270808	2463	7161	7042,2353,1385,1513,6850,3458,11006,54,4792,5535,3716,8878,9020,2213,6773,7189,5604,5530,10000,3456,7048,4790,11026,10454,11024,3552,3937,10859,2355,10379,5295,9021,5296,207,3459,3551,7186,2209,5602,2212,3454,11027,4286,7305,6772,208,3725,3726,8503,5468,5608,23118,3553,7124,5290	TGFB2,FOS,CREB1,CTSK,SYK,IFNG,LILRB4,ACP5,NFKBIA,PPP3R2,JAK1,SQSTM1,MAP3K14,FCGR2B,STAT2,TRAF6,MAP2K1,PPP3CA,AKT3,IFNB1,TGFBR2,NFKB1,LILRA3,TAB1,LILRA1,IL1A,LCP2,LILRB1,FOSL2,IRF9,PIK3R1,SOCS3,PIK3R2,AKT1,IFNGR1,IKBKB,TRAF2,FCGR1A,MAPK10,FCGR2A,IFNAR1,LILRA2,MITF,TYROBP,STAT1,AKT2,JUN,JUNB,PIK3R3,PPARG,MAP2K6,TAB2,IL1B,TNF,PIK3CA
ko03022	Basal transcription factors	0.0310843515115206	-3.47105075325999	45	22	0.00893219650832318	2463	7161	2960,4331,6873,2969,6881,6880,2968,2957,2961,404672,902,2958,2071,6882,27097,1022,6879,9569,2966,2959,2963,2962	GTF2E1,MNAT1,TAF2,GTF2I,TAF10,TAF9,GTF2H4,GTF2A1,GTF2E2,GTF2H5,CCNH,GTF2A2,ERCC3,TAF11,TAF5L,CDK7,TAF7,GTF2IRD1,GTF2H2,GTF2B,GTF2F2,GTF2F1
hsa03022	Basal transcription factors	0.0310843515115206	-3.47105075325999	45	22	0.00893219650832318	2463	7161	6881,2969,6873,2960,4331,2961,2957,6880,2968,6882,2071,2958,902,404672,2959,2962,2963,9569,2966,27097,6879,1022	TAF10,GTF2I,TAF2,GTF2E1,MNAT1,GTF2E2,GTF2A1,TAF9,GTF2H4,TAF11,ERCC3,GTF2A2,CCNH,GTF2H5,GTF2B,GTF2F1,GTF2F2,GTF2IRD1,GTF2H2,TAF5L,TAF7,CDK7
ko05210	Colorectal cancer	0.0324307136660289	-3.42864935255201	60	28	0.0113682501015022	2463	7161	7048,4609,10000,1499,5604,208,3725,572,4087,5290,581,8503,5880,207,4088,5296,7157,3845,5295,7043,7042,2353,5894,332,595,5602,4089,2956	TGFBR2,MYC,AKT3,CTNNB1,MAP2K1,AKT2,JUN,BAD,SMAD2,PIK3CA,BAX,PIK3R3,RAC2,AKT1,SMAD3,PIK3R2,TP53,KRAS,PIK3R1,TGFB3,TGFB2,FOS,RAF1,BIRC5,CCND1,MAPK10,SMAD4,MSH6
hsa05210	Colorectal cancer	0.0324307136660289	-3.42864935255201	60	28	0.0113682501015022	2463	7161	5880,8503,581,4087,5290,572,208,3725,1499,5604,10000,4609,7048,2956,4089,5602,595,5894,332,2353,7043,7042,5295,3845,7157,5296,4088,207	RAC2,PIK3R3,BAX,SMAD2,PIK3CA,BAD,AKT2,JUN,CTNNB1,MAP2K1,AKT3,MYC,TGFBR2,MSH6,SMAD4,MAPK10,CCND1,RAF1,BIRC5,FOS,TGFB3,TGFB2,PIK3R1,KRAS,TP53,PIK3R2,SMAD3,AKT1
ko01212	Fatty acid metabolism	0.0360079721792319	-3.32401491561922	48	23	0.00933820544051969	2463	7161	36,1376,38,201562,2182,1962,401494,1375,3030,51102,5538,27349,10449,9524,79966,3033,79071,51,9200,9415,51495,31,35	ACADSB,CPT2,ACAT1,HACD2,ACSL4,EHHADH,HACD4,CPT1B,HADHA,MECR,PPT1,MCAT,ACAA2,TECR,SCD5,HADH,ELOVL6,ACOX1,HACD1,FADS2,HACD3,ACACA,ACADS
hsa01212	Fatty acid metabolism	0.0360079721792319	-3.32401491561922	48	23	0.00933820544051969	2463	7161	10449,9524,3033,79071,79966,51,9200,51495,9415,35,31,1376,36,2182,201562,38,401494,1962,1375,3030,51102,27349,5538	ACAA2,TECR,HADH,ELOVL6,SCD5,ACOX1,HACD1,HACD3,FADS2,ACADS,ACACA,CPT2,ACADSB,ACSL4,HACD2,ACAT1,HACD4,EHHADH,CPT1B,HADHA,MECR,MCAT,PPT1
ko04210	Apoptosis	0.036057937448158	-3.32262826061991	138	58	0.0235485180673975	2463	7161	7124,572,5290,1676,581,8503,597,1965,6709,9131,208,3725,100506742,356,3551,329,7186,598,5602,4001,10038,7185,207,10376,3562,5296,3845,1509,5295,60,355,5366,578,4790,824,8743,10000,1649,4170,5604,27429,4616,10912,7846,5894,332,9020,1508,468,1075,3265,4792,7157,823,4000,1513,1647,2353	TNF,BAD,PIK3CA,DFFA,BAX,PIK3R3,BCL2A1,EIF2S1,SPTAN1,AIFM1,AKT2,JUN,CASP12,FASLG,IKBKB,BIRC2,TRAF2,BCL2L1,MAPK10,LMNB1,PARP2,TRAF1,AKT1,TUBA1B,IL3,PIK3R2,KRAS,CTSD,PIK3R1,ACTB,FAS,PMAIP1,BAK1,NFKB1,CAPN2,TNFSF10,AKT3,DDIT3,MCL1,MAP2K1,HTRA2,GADD45B,GADD45G,TUBA1A,RAF1,BIRC5,MAP3K14,CTSB,ATF4,CTSC,HRAS,NFKBIA,TP53,CAPN1,LMNA,CTSK,GADD45A,FOS
hsa04210	Apoptosis	0.036057937448158	-3.32262826061991	138	58	0.0235485180673975	2463	7161	597,8503,581,1676,5290,572,7124,100506742,208,3725,9131,6709,1965,10038,7185,4001,7186,329,5602,598,356,3551,1509,5295,3845,5296,207,3562,10376,60,7846,10912,4616,27429,4170,5604,10000,8743,1649,578,824,4790,355,5366,4792,3265,468,1075,1508,9020,5894,332,1647,2353,1513,823,4000,7157	BCL2A1,PIK3R3,BAX,DFFA,PIK3CA,BAD,TNF,CASP12,AKT2,JUN,AIFM1,SPTAN1,EIF2S1,PARP2,TRAF1,LMNB1,TRAF2,BIRC2,MAPK10,BCL2L1,FASLG,IKBKB,CTSD,PIK3R1,KRAS,PIK3R2,AKT1,IL3,TUBA1B,ACTB,TUBA1A,GADD45G,GADD45B,HTRA2,MCL1,MAP2K1,AKT3,TNFSF10,DDIT3,BAK1,CAPN2,NFKB1,FAS,PMAIP1,NFKBIA,HRAS,ATF4,CTSC,CTSB,MAP3K14,RAF1,BIRC5,GADD45A,FOS,CTSK,CAPN1,LMNA,TP53
ko05133	Pertussis	0.0387681596246701	-3.25015599748273	76	34	0.0138043036946813	2463	7161	3569,3552,3553,7124,3659,29108,3586,114548,4615,4790,148022,2771,3725,7189,5602,653509,1072,1073,3576,7099,3661,51561,114609,3593,3592,51806,353376,3394,51135,2353,23643,2773,714,929	IL6,IL1A,IL1B,TNF,IRF1,PYCARD,IL10,NLRP3,MYD88,NFKB1,TICAM1,GNAI2,JUN,TRAF6,MAPK10,SFTPA1,CFL1,CFL2,CXCL8,TLR4,IRF3,IL23A,TIRAP,IL12B,IL12A,CALML5,TICAM2,IRF8,IRAK4,FOS,LY96,GNAI3,C1QC,CD14
hsa05133	Pertussis	0.0387681596246701	-3.25015599748273	76	34	0.0138043036946813	2463	7161	3553,3552,3569,7124,29108,3659,3586,114548,4615,148022,4790,2771,3725,7189,653509,5602,1072,1073,7099,3576,51561,3661,114609,3593,3592,353376,51806,51135,3394,23643,2353,2773,929,714	IL1B,IL1A,IL6,TNF,PYCARD,IRF1,IL10,NLRP3,MYD88,TICAM1,NFKB1,GNAI2,JUN,TRAF6,SFTPA1,MAPK10,CFL1,CFL2,TLR4,CXCL8,IL23A,IRF3,TIRAP,IL12B,IL12A,TICAM2,CALML5,IRAK4,IRF8,LY96,FOS,GNAI3,CD14,C1QC
hsa_M00108	C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone	0.0406560344477217	-3.20260800510732	3	3	0.00121802679658952	2463	7161	1585,1584,1589	CYP11B2,CYP11B1,CYP21A2
M00108	C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone	0.0406560344477217	-3.20260800510732	3	3	0.00121802679658952	2463	7161	1585,1589,1584	CYP11B2,CYP21A2,CYP11B1
hsa_M00009	Citrate cycle (TCA cycle, Krebs cycle)	0.0413255479208318	-3.18627437654064	22	12	0.0048721071863581	2463	7161	8801,3418,48,3417,3420,1743,6391,4190,6390,3419,50,55753	SUCLG2,IDH2,ACO1,IDH1,IDH3B,DLST,SDHC,MDH1,SDHB,IDH3A,ACO2,OGDHL
M00009	Citrate cycle (TCA cycle, Krebs cycle)	0.0413255479208318	-3.18627437654064	22	12	0.0048721071863581	2463	7161	3417,55753,6390,3419,1743,3420,6391,8801,48,3418,4190,50	IDH1,OGDHL,SDHB,IDH3A,DLST,IDH3B,SDHC,SUCLG2,ACO1,IDH2,MDH1,ACO2
ko03013	RNA transport	0.0439795704911904	-3.12403005990616	166	68	0.0276086073893626	2463	7161	8894,138716,10284,140886,26999,1974,10762,11260,10289,9513,57122,1979,6612,10419,57187,129401,8669,7341,65109,80336,8664,8891,1965,1977,10248,54913,10605,79760,7919,55916,84305,51808,5901,54960,51367,9972,23636,8893,79023,84321,3646,7514,79228,55110,6396,9775,26986,4116,6613,9669,1964,7329,9470,29107,57510,11097,22794,6606,8666,8637,11102,9984,1915,22916,1975,10189,79897,8892	EIF2S2,RPP25L,SAP18,PABPC5,CYFIP2,EIF4A2,NUP50,XPOT,EIF1B,FXR2,NUP107,EIF4EBP2,SUMO3,PRMT5,THOC2,NUP35,EIF3J,SUMO1,UPF3B,PABPC1L,EIF3D,EIF2B3,EIF2S1,EIF4E,POP7,RPP25,PAIP1,GEMIN7,DDX39B,NXT2,PYM1,PHAX,RAN,GEMIN8,POP5,NUP153,NUP62,EIF2B5,NUP37,THOC3,EIF3E,XPO1,THOC6,MAGOHB,SEC13,EIF4A3,PABPC1,MAGOH,SUMO2,EIF5B,EIF1AX,UBE2I,EIF4E2,NXT1,XPO5,NUP42,CASC3,SMN1,EIF3G,EIF4EBP3,RPP14,THOC1,EEF1A1,NCBP2,EIF4B,ALYREF,RPP21,EIF2B2
hsa03013	RNA transport	0.0439795704911904	-3.12403005990616	166	68	0.0276086073893626	2463	7161	7514,3646,79228,55110,9775,6396,26986,4116,6613,9669,1964,7329,9470,29107,57510,11097,8666,6606,22794,8637,9984,11102,1915,22916,1975,79897,10189,8892,138716,8894,140886,10284,26999,11260,10762,1974,10289,57122,9513,1979,6612,10419,57187,8669,129401,7341,65109,80336,8664,8891,1965,1977,10248,54913,10605,79760,7919,55916,84305,51808,54960,5901,51367,9972,23636,79023,8893,84321	XPO1,EIF3E,THOC6,MAGOHB,EIF4A3,SEC13,PABPC1,MAGOH,SUMO2,EIF5B,EIF1AX,UBE2I,EIF4E2,NXT1,XPO5,NUP42,EIF3G,SMN1,CASC3,EIF4EBP3,THOC1,RPP14,EEF1A1,NCBP2,EIF4B,RPP21,ALYREF,EIF2B2,RPP25L,EIF2S2,PABPC5,SAP18,CYFIP2,XPOT,NUP50,EIF4A2,EIF1B,NUP107,FXR2,EIF4EBP2,SUMO3,PRMT5,THOC2,EIF3J,NUP35,SUMO1,UPF3B,PABPC1L,EIF3D,EIF2B3,EIF2S1,EIF4E,POP7,RPP25,PAIP1,GEMIN7,DDX39B,NXT2,PYM1,PHAX,GEMIN8,RAN,POP5,NUP153,NUP62,NUP37,EIF2B5,THOC3
hsa05203	Viral carcinogenesis	0.0446118679995992	-3.10975535670836	201	81	0.0328867235079172	2463	7161	572,5290,896,581,8841,85236,7529,8503,2958,7532,158983,3665,991,6776,1959,983,1026,10488,4055,3725,1234,1019,55697,890,1233,595,1387,7186,4193,148327,5700,7185,7337,255626,2961,998,5296,81,3845,10379,5295,1027,1739,5423,7533,5366,578,2959,4790,3190,8348,28973,2966,5567,1232,5925,3716,5902,79885,468,6714,3265,2033,5610,3572,4792,2960,3516,3661,10013,7157,7534,8970,1385,8345,8342,6850,10014,2957,1021,2968	BAD,PIK3CA,CCND3,BAX,HDAC3,H2BC12,YWHAB,PIK3R3,GTF2A2,YWHAG,H2BW1,IRF7,CDC20,STAT5A,EGR2,CDK1,CDKN1A,CREB3,LTBR,JUN,CCR5,CDK4,VAC14,CCNA2,CCR4,CCND1,CREBBP,TRAF2,MDM2,CREB3L4,PSMC1,TRAF1,UBE3A,H2BC1,GTF2E2,CDC42,PIK3R2,ACTN4,KRAS,IRF9,PIK3R1,CDKN1B,DLG1,POLB,YWHAH,PMAIP1,BAK1,GTF2B,NFKB1,HNRNPK,H2BC17,MRPS18B,GTF2H2,PRKACB,CCR3,RB1,JAK1,RANBP1,HDAC11,ATF4,SRC,HRAS,EP300,EIF2AK2,IL6ST,NFKBIA,GTF2E1,RBPJ,IRF3,HDAC6,TP53,YWHAZ,H2BC11,CREB1,H2BC9,H2BC14,SYK,HDAC5,GTF2A1,CDK6,GTF2H4
ko05203	Viral carcinogenesis	0.0446118679995992	-3.10975535670836	201	81	0.0328867235079172	2463	7161	255626,2961,7337,5296,998,81,3845,10379,5295,890,595,1233,55697,4193,1387,7186,148327,5700,7185,6776,1959,991,1026,10488,983,3725,4055,1019,1234,5290,572,896,581,8841,7532,2958,85236,8503,7529,158983,3665,10013,7534,7157,8970,6850,8342,2957,10014,1385,8345,2968,1021,1232,5925,5567,5902,79885,468,3716,2033,3572,5610,6714,3265,2960,4792,3516,3661,2959,578,4790,5366,3190,8348,28973,2966,1027,1739,5423,7533	H2BC1,GTF2E2,UBE3A,PIK3R2,CDC42,ACTN4,KRAS,IRF9,PIK3R1,CCNA2,CCND1,CCR4,VAC14,MDM2,CREBBP,TRAF2,CREB3L4,PSMC1,TRAF1,STAT5A,EGR2,CDC20,CDKN1A,CREB3,CDK1,JUN,LTBR,CDK4,CCR5,PIK3CA,BAD,CCND3,BAX,HDAC3,YWHAG,GTF2A2,H2BC12,PIK3R3,YWHAB,H2BW1,IRF7,HDAC6,YWHAZ,TP53,H2BC11,SYK,H2BC14,GTF2A1,HDAC5,CREB1,H2BC9,GTF2H4,CDK6,CCR3,RB1,PRKACB,RANBP1,HDAC11,ATF4,JAK1,EP300,IL6ST,EIF2AK2,SRC,HRAS,GTF2E1,NFKBIA,RBPJ,IRF3,GTF2B,BAK1,NFKB1,PMAIP1,HNRNPK,H2BC17,MRPS18B,GTF2H2,CDKN1B,DLG1,POLB,YWHAH
ko03018	RNA degradation	0.0470792684190973	-3.05592253581238	77	34	0.0138043036946813	2463	7161	2023,80349,4848,10950,2026,10200,11157,694,84186,51010,29883,3329,9337,57472,23658,246175,10438,11340,11044,51013,140886,7832,27258,57819,80336,115752,54512,10766,131870,167227,51691,26986,25804,80153	ENO1,SKIC8,CNOT2,BTG3,ENO2,MPHOSPH6,LSM6,BTG1,ZCCHC7,EXOSC3,CNOT7,HSPD1,CNOT8,CNOT6,LSM5,CNOT6L,C1D,EXOSC8,TENT4A,EXOSC1,PABPC5,BTG2,LSM3,LSM2,PABPC1L,DIS3L,EXOSC4,TOB2,NUDT16,DCP2,LSM8,PABPC1,LSM4,EDC3
hsa03018	RNA degradation	0.0470792684190973	-3.05592253581238	77	34	0.0138043036946813	2463	7161	26986,25804,80153,51691,54512,10766,167227,131870,80336,57819,115752,7832,140886,51013,27258,11044,11340,246175,10438,23658,9337,3329,57472,29883,51010,84186,11157,10200,694,10950,2026,4848,2023,80349	PABPC1,LSM4,EDC3,LSM8,EXOSC4,TOB2,DCP2,NUDT16,PABPC1L,LSM2,DIS3L,BTG2,PABPC5,EXOSC1,LSM3,TENT4A,EXOSC8,CNOT6L,C1D,LSM5,CNOT8,HSPD1,CNOT6,CNOT7,EXOSC3,ZCCHC7,LSM6,MPHOSPH6,BTG1,BTG3,ENO2,CNOT2,ENO1,SKIC8
M00361	Nucleotide sugar biosynthesis, eukaryotes	0.0492074661796612	-3.01170991537786	9	6	0.00243605359317905	2463	7161	29926,7360,2582,6675,7358,29925	GMPPA,UGP2,GALE,UAP1,UGDH,GMPPB
hsa_M00361	Nucleotide sugar biosynthesis, eukaryotes	0.0492074661796612	-3.01170991537786	9	6	0.00243605359317905	2463	7161	6675,2582,7360,29926,29925,7358	UAP1,GALE,UGP2,GMPPA,GMPPB,UGDH
hsa_M00289	RF-C complex	0.0506591662125362	-2.98263509304116	5	4	0.00162403572878603	2463	7161	5983,5982,5985,5984	RFC3,RFC2,RFC5,RFC4
M00289	RF-C complex	0.0506591662125362	-2.98263509304116	5	4	0.00162403572878603	2463	7161	5984,5982,5983,5985	RFC4,RFC2,RFC3,RFC5
M00397	Lsm 1-7 complex	0.0515930954964466	-2.96436742365614	7	5	0.00203004466098254	2463	7161	27258,25804,11157,23658,57819	LSM3,LSM4,LSM6,LSM5,LSM2
hsa_M00397	Lsm 1-7 complex	0.0515930954964466	-2.96436742365614	7	5	0.00203004466098254	2463	7161	11157,25804,27258,57819,23658	LSM6,LSM4,LSM3,LSM2,LSM5
hsa04066	HIF-1 signaling pathway	0.0523543215562082	-2.94972079385579	101	43	0.0174583840844499	2463	7161	9470,4790,10000,2026,5604,6513,7076,1027,8453,3569,5578,3458,6921,7018,7422,3480,2033,3939,5579,112398,1977,1026,4055,208,2023,2056,5160,5290,7037,3479,8503,818,5230,112399,207,284,5296,5295,5162,7099,1387,3459,2597	EIF4E2,NFKB1,AKT3,ENO2,MAP2K1,SLC2A1,TIMP1,CDKN1B,CUL2,IL6,PRKCA,IFNG,ELOC,TF,VEGFA,IGF1R,EP300,LDHA,PRKCB,EGLN2,EIF4E,CDKN1A,LTBR,AKT2,ENO1,EPO,PDHA1,PIK3CA,TFRC,IGF1,PIK3R3,CAMK2G,PGK1,EGLN3,AKT1,ANGPT1,PIK3R2,PIK3R1,PDHB,TLR4,CREBBP,IFNGR1,GAPDH
M00430	Exon junction complex (EJC)	0.0530856266219289	-2.93584907246215	18	10	0.00406008932196508	2463	7161	10189,9775,65109,55110,22794,55916,29107,7919,10284,4116	ALYREF,EIF4A3,UPF3B,MAGOHB,CASC3,NXT2,NXT1,DDX39B,SAP18,MAGOH
hsa_M00430	Exon junction complex (EJC)	0.0530856266219289	-2.93584907246215	18	10	0.00406008932196508	2463	7161	55916,29107,4116,7919,10284,9775,10189,65109,55110,22794	NXT2,NXT1,MAGOH,DDX39B,SAP18,EIF4A3,ALYREF,UPF3B,MAGOHB,CASC3
ko04662	B cell receptor signaling pathway	0.0539959685000258	-2.91884589261179	70	31	0.0125862768980918	2463	7161	5290,974,6655,8915,975,5880,8503,4790,5579,3636,10000,5530,3725,208,5604,2213,118788,5894,3551,25780,5535,3265,4793,7410,4792,207,5296,6850,3845,2353,5295	PIK3CA,CD79B,SOS2,BCL10,CD81,RAC2,PIK3R3,NFKB1,PRKCB,INPPL1,AKT3,PPP3CA,JUN,AKT2,MAP2K1,FCGR2B,PIK3AP1,RAF1,IKBKB,RASGRP3,PPP3R2,HRAS,NFKBIB,VAV2,NFKBIA,AKT1,PIK3R2,SYK,KRAS,FOS,PIK3R1
hsa04662	B cell receptor signaling pathway	0.0539959685000258	-2.91884589261179	70	31	0.0125862768980918	2463	7161	5894,2213,118788,3551,3265,5535,25780,7410,4793,4792,207,5296,3845,6850,5295,2353,974,6655,5290,8915,975,8503,5880,3636,4790,5579,5530,10000,5604,3725,208	RAF1,FCGR2B,PIK3AP1,IKBKB,HRAS,PPP3R2,RASGRP3,VAV2,NFKBIB,NFKBIA,AKT1,PIK3R2,KRAS,SYK,PIK3R1,FOS,CD79B,SOS2,PIK3CA,BCL10,CD81,PIK3R3,RAC2,INPPL1,NFKB1,PRKCB,PPP3CA,AKT3,MAP2K1,JUN,AKT2
hsa00240	Pyrimidine metabolism	0.0555366894509013	-2.89071140545364	104	44	0.0178643930166464	2463	7161	4830,114112,171568,84172,54107,956,23649,5433,79077,51251,5441,83549,51727,10587,7371,5425,1635,1841,22978,56655,9583,5431,10621,51082,7372,139596,5558,57804,5436,4860,54963,5432,7298,4831,5435,1633,84265,5438,6240,55703,4833,30834,318,7296	NME1,TXNRD3,POLR3H,POLR1B,POLE3,ENTPD3,POLA2,POLR2D,DCTPP1,NT5C3A,POLR2L,UCK1,CMPK1,TXNRD2,UCK2,POLD2,DCTD,DTYMK,NT5C2,POLE4,ENTPD4,POLR2B,POLR3F,POLR1D,UMPS,UPRT,PRIM2,POLD4,POLR2G,PNP,UCKL1,POLR2C,TYMS,NME2,POLR2F,DCK,POLR3GL,POLR2I,RRM1,POLR3B,NME4,POLR1H,NUDT2,TXNRD1
ko00240	Pyrimidine metabolism	0.0555366894509013	-2.89071140545364	104	44	0.0178643930166464	2463	7161	4830,114112,171568,54107,84172,956,23649,51251,5433,79077,5441,83549,51727,10587,7371,1635,5425,22978,1841,56655,9583,5431,10621,51082,139596,7372,5558,57804,4860,5436,54963,7298,5432,5435,4831,84265,1633,5438,6240,55703,30834,4833,7296,318	NME1,TXNRD3,POLR3H,POLE3,POLR1B,ENTPD3,POLA2,NT5C3A,POLR2D,DCTPP1,POLR2L,UCK1,CMPK1,TXNRD2,UCK2,DCTD,POLD2,NT5C2,DTYMK,POLE4,ENTPD4,POLR2B,POLR3F,POLR1D,UPRT,UMPS,PRIM2,POLD4,PNP,POLR2G,UCKL1,TYMS,POLR2C,POLR2F,NME2,POLR3GL,DCK,POLR2I,RRM1,POLR3B,POLR1H,NME4,TXNRD1,NUDT2
ko04152	AMPK signaling pathway	0.056873763519006	-2.86692114227252	120	50	0.0203004466098254	2463	7161	5516,8789,6794,3480,31,55437,1938,5529,5208,51094,1080,200186,79966,3953,1385,5564,5862,5518,79602,6009,948,1375,2997,10000,92579,5523,595,890,148327,9370,207,5296,3952,5295,5290,5571,3479,8503,5468,51719,23216,2203,5106,51552,148,10488,208,5522,5525,9230	PPP2CB,FBP2,STK11,IGF1R,ACACA,STRADB,EEF2,PPP2R5E,PFKFB2,ADIPOR1,CFTR,CRTC2,SCD5,LEPR,CREB1,PRKAB1,RAB2A,PPP2R1A,ADIPOR2,RHEB,CD36,CPT1B,GYS1,AKT3,G6PC3,PPP2R3A,CCND1,CCNA2,CREB3L4,ADIPOQ,AKT1,PIK3R2,LEP,PIK3R1,PIK3CA,PRKAG1,IGF1,PIK3R3,PPARG,CAB39,TBC1D1,FBP1,PCK2,RAB14,ADRA1A,CREB3,AKT2,PPP2R2C,PPP2R5A,RAB11B
hsa04152	AMPK signaling pathway	0.056873763519006	-2.86692114227252	120	50	0.0203004466098254	2463	7161	3953,1385,1080,200186,79966,1938,5529,5208,51094,5516,8789,6794,3480,55437,31,5523,948,1375,2997,92579,10000,6009,5564,5862,5518,79602,3952,5295,207,5296,9370,595,890,148327,208,5522,5525,9230,2203,5106,51552,148,10488,8503,5468,23216,51719,5290,5571,3479	LEPR,CREB1,CFTR,CRTC2,SCD5,EEF2,PPP2R5E,PFKFB2,ADIPOR1,PPP2CB,FBP2,STK11,IGF1R,STRADB,ACACA,PPP2R3A,CD36,CPT1B,GYS1,G6PC3,AKT3,RHEB,PRKAB1,RAB2A,PPP2R1A,ADIPOR2,LEP,PIK3R1,AKT1,PIK3R2,ADIPOQ,CCND1,CCNA2,CREB3L4,AKT2,PPP2R2C,PPP2R5A,RAB11B,FBP1,PCK2,RAB14,ADRA1A,CREB3,PIK3R3,PPARG,TBC1D1,CAB39,PIK3CA,PRKAG1,IGF1
ko00980	Metabolism of xenobiotics by cytochrome P450	0.0584884035251399	-2.83892677473405	73	32	0.0129922858302883	2463	7161	1645,2952,4259,653689,1577,2938,2946,1565,1559,373156,2939,1572,119391,2947,4258,874,2941,220,79799,2052,8574,27306,2948,3290,9446,54658,124,2949,125,2950,1545,1543	AKR1C1,GSTT1,MGST3,GSTT2B,CYP3A5,GSTA1,GSTM2,CYP2D6,CYP2C9,GSTK1,GSTA2,CYP2F1,GSTO2,GSTM3,MGST2,CBR3,GSTA4,ALDH1A3,UGT2A3,EPHX1,AKR7A2,HPGDS,GSTM4,HSD11B1,GSTO1,UGT1A1,ADH1A,GSTM5,ADH1B,GSTP1,CYP1B1,CYP1A1
hsa00980	Metabolism of xenobiotics by cytochrome P450	0.0584884035251399	-2.83892677473405	73	32	0.0129922858302883	2463	7161	8574,27306,2052,9446,2948,3290,874,2941,79799,220,2950,1543,1545,54658,124,125,2949,2946,1577,653689,2938,1559,373156,1565,1645,4259,2952,119391,2947,4258,2939,1572	AKR7A2,HPGDS,EPHX1,GSTO1,GSTM4,HSD11B1,CBR3,GSTA4,UGT2A3,ALDH1A3,GSTP1,CYP1A1,CYP1B1,UGT1A1,ADH1A,ADH1B,GSTM5,GSTM2,CYP3A5,GSTT2B,GSTA1,CYP2C9,GSTK1,CYP2D6,AKR1C1,MGST3,GSTT1,GSTO2,GSTM3,MGST2,GSTA2,CYP2F1
hsa03430	Mismatch repair	0.0600019270582536	-2.81337859963824	23	12	0.0048721071863581	2463	7161	5985,27030,6118,5983,6742,5982,57804,5425,5984,2956,5111,6119	RFC5,MLH3,RPA2,RFC3,SSBP1,RFC2,POLD4,POLD2,RFC4,MSH6,PCNA,RPA3
ko03430	Mismatch repair	0.0600019270582536	-2.81337859963824	23	12	0.0048721071863581	2463	7161	57804,6119,5111,5984,2956,6742,5982,5983,27030,6118,5985,5425	POLD4,RPA3,PCNA,RFC4,MSH6,SSBP1,RFC2,RFC3,MLH3,RPA2,RFC5,POLD2
ko04623	Cytosolic DNA-sensing pathway	0.0620134013740674	-2.78040476609971	63	28	0.0113682501015022	2463	7161	3553,3569,3447,84265,3665,29108,115004,23586,29110,3456,55703,10621,3446,4790,6352,3551,3440,388372,3606,171568,4793,4792,3661,51082,5441,3627,5435,57506	IL1B,IL6,IFNA13,POLR3GL,IRF7,PYCARD,CGAS,RIGI,TBK1,IFNB1,POLR3B,POLR3F,IFNA10,NFKB1,CCL5,IKBKB,IFNA2,CCL4L1,IL18,POLR3H,NFKBIB,NFKBIA,IRF3,POLR1D,POLR2L,CXCL10,POLR2F,MAVS
hsa04623	Cytosolic DNA-sensing pathway	0.0620134013740674	-2.78040476609971	63	28	0.0113682501015022	2463	7161	3569,3447,3553,84265,3665,29108,115004,23586,3456,29110,55703,10621,4790,3446,6352,3551,3440,3606,388372,171568,3661,51082,4792,4793,5441,3627,5435,57506	IL6,IFNA13,IL1B,POLR3GL,IRF7,PYCARD,CGAS,RIGI,IFNB1,TBK1,POLR3B,POLR3F,NFKB1,IFNA10,CCL5,IKBKB,IFNA2,IL18,CCL4L1,POLR3H,IRF3,POLR1D,NFKBIA,NFKBIB,POLR2L,CXCL10,POLR2F,MAVS
hsa04151	PI3K-Akt signaling pathway	0.06218096089363	-2.77770642105134	341	131	0.0531871701177426	2463	7161	2252,6655,54541,3479,1442,3447,5617,2787,8503,7529,7097,7450,7059,3673,1977,3574,7424,8074,1944,5525,595,7099,4193,598,148327,356,3551,2784,2258,3717,207,3562,1902,5296,27006,2790,1027,5518,5578,9170,1975,10161,2688,7184,4609,3561,9470,92579,3456,2785,3913,4170,5516,3440,5529,3558,3265,51764,7143,59345,200186,7534,7157,672,6850,1385,3655,3326,3685,5290,2255,2056,572,896,7532,2246,3560,5106,1026,10488,3693,208,2791,5522,54331,1019,3815,118788,3454,6696,2248,3565,284,3559,8822,5728,3845,2793,5295,5294,1278,3569,7533,6009,2260,3320,55970,3446,4790,2782,10000,2997,5604,5523,2257,3696,5894,1128,1969,5008,468,7422,3716,6794,3480,1946,4233,2690,8823,2788,1021	FGF7,SOS2,DDIT4,IGF1,CSH1,IFNA13,PRL,GNG5,PIK3R3,YWHAB,TLR2,VWF,THBS3,ITGA2,EIF4E,IL7,VEGFC,FGF23,EFNA3,PPP2R5A,CCND1,TLR4,MDM2,BCL2L1,CREB3L4,FASLG,IKBKB,GNB3,FGF13,JAK2,AKT1,IL3,LPAR1,PIK3R2,FGF22,GNG10,CDKN1B,PPP2R1A,PRKCA,LPAR2,EIF4B,LPAR6,GH1,HSP90B1,MYC,IL2RG,EIF4E2,G6PC3,IFNB1,GNG3,LAMB2,MCL1,PPP2CB,IFNA2,PPP2R5E,IL2,HRAS,GNG13,TNR,GNB4,CRTC2,YWHAZ,TP53,BRCA1,SYK,CREB1,ITGA6,HSP90AB1,ITGAV,PIK3CA,FGF10,EPO,BAD,CCND3,YWHAG,FGF1,IL2RB,PCK2,CDKN1A,CREB3,ITGB5,AKT2,GNG11,PPP2R2C,GNG2,CDK4,KIT,PIK3AP1,IFNAR1,SPP1,FGF3,IL4,ANGPT1,IL2RA,FGF17,PTEN,KRAS,GNGT2,PIK3R1,PIK3CG,COL1A2,IL6,YWHAH,RHEB,FGFR1,HSP90AA1,GNG12,IFNA10,NFKB1,GNB1,AKT3,GYS1,MAP2K1,PPP2R3A,FGF12,ITGB8,RAF1,CHRM1,EPHA2,OSM,ATF4,VEGFA,JAK1,STK11,IGF1R,EFNA5,MET,GHR,FGF16,GNG7,CDK6
ko04151	PI3K-Akt signaling pathway	0.06218096089363	-2.77770642105134	341	131	0.0531871701177426	2463	7161	208,3815,5522,2791,1019,54331,5106,1026,10488,3693,7532,2246,3560,572,2255,2056,5290,896,5728,3845,5295,2793,3559,3565,284,8822,2248,118788,3454,6696,5604,3696,2257,5523,3446,4790,2782,10000,2997,55970,3320,7533,2260,6009,5294,1278,3569,2788,1021,4233,8823,2690,1946,5894,1128,7422,3480,6794,3716,5008,1969,468,7424,8074,1944,5525,3673,3574,1977,8503,7529,7097,5617,2787,7059,7450,6655,54541,2252,3447,1442,3479,27006,207,3562,3717,5296,1902,2784,2258,7099,595,356,3551,4193,148327,598,4170,3913,3561,9470,7184,4609,2785,92579,3456,5578,1975,9170,10161,2688,1027,2790,5518,1385,3655,6850,3685,3326,59345,7157,7534,672,200186,3558,3265,5529,7143,51764,5516,3440	AKT2,KIT,PPP2R2C,GNG11,CDK4,GNG2,PCK2,CDKN1A,CREB3,ITGB5,YWHAG,FGF1,IL2RB,BAD,FGF10,EPO,PIK3CA,CCND3,PTEN,KRAS,PIK3R1,GNGT2,IL2RA,IL4,ANGPT1,FGF17,FGF3,PIK3AP1,IFNAR1,SPP1,MAP2K1,ITGB8,FGF12,PPP2R3A,IFNA10,NFKB1,GNB1,AKT3,GYS1,GNG12,HSP90AA1,YWHAH,FGFR1,RHEB,PIK3CG,COL1A2,IL6,GNG7,CDK6,MET,FGF16,GHR,EFNA5,RAF1,CHRM1,VEGFA,IGF1R,STK11,JAK1,OSM,EPHA2,ATF4,VEGFC,FGF23,EFNA3,PPP2R5A,ITGA2,IL7,EIF4E,PIK3R3,YWHAB,TLR2,PRL,GNG5,THBS3,VWF,SOS2,DDIT4,FGF7,IFNA13,CSH1,IGF1,FGF22,AKT1,IL3,JAK2,PIK3R2,LPAR1,GNB3,FGF13,TLR4,CCND1,FASLG,IKBKB,MDM2,CREB3L4,BCL2L1,MCL1,LAMB2,IL2RG,EIF4E2,HSP90B1,MYC,GNG3,G6PC3,IFNB1,PRKCA,EIF4B,LPAR2,LPAR6,GH1,CDKN1B,GNG10,PPP2R1A,CREB1,ITGA6,SYK,ITGAV,HSP90AB1,GNB4,TP53,YWHAZ,BRCA1,CRTC2,IL2,HRAS,PPP2R5E,TNR,GNG13,PPP2CB,IFNA2
hsa04014	Ras signaling pathway	0.0637617159125741	-2.75260233280813	226	89	0.0361347949654892	2463	7161	4233,8823,2788,53358,5322,382,5894,1969,7422,3480,5899,1946,5062,100137049,4790,2782,10000,2002,5604,2257,6789,2260,23179,55970,81579,284,5878,8822,998,3845,2793,5295,5781,2248,25780,2549,7074,6464,5579,208,2791,54331,9771,3815,57144,5290,2255,572,5880,2246,59345,51806,8036,5567,5868,3265,51764,5906,2785,56924,11145,8315,2790,10235,5578,55770,5908,22800,22808,5898,207,5296,27006,5602,598,356,3551,2784,2258,29110,7424,8074,1944,2252,6655,3479,5863,2787,8503	MET,FGF16,GNG7,SHC3,PLA2G5,ARF6,RAF1,EPHA2,VEGFA,IGF1R,RALB,EFNA5,PAK2,PLA2G4B,NFKB1,GNB1,AKT3,ELK1,MAP2K1,FGF12,STK4,FGFR1,RGL1,GNG12,PLA2G12A,ANGPT1,RAB5C,FGF17,CDC42,KRAS,GNGT2,PIK3R1,PTPN11,FGF3,RASGRP3,GAB1,TIAM1,SHC1,PRKCB,AKT2,GNG11,GNG2,RAPGEF5,KIT,PAK5,PIK3CA,FGF10,BAD,RAC2,FGF1,GNB4,CALML5,SHOC2,PRKACB,RAB5A,HRAS,GNG13,RAP1A,GNG3,PAK6,PLAAT3,BRAP,GNG10,RASGRP2,PRKCA,EXOC2,RAP1B,RRAS2,MRAS,RALA,AKT1,PIK3R2,FGF22,MAPK10,BCL2L1,FASLG,IKBKB,GNB3,FGF13,TBK1,VEGFC,FGF23,EFNA3,FGF7,SOS2,IGF1,RGL2,GNG5,PIK3R3
hsa03410	Base excision repair	0.0660608486875016	-2.71717901187977	33	16	0.00649614291514413	2463	7161	5111,3146,10038,328,4968,3980,27301,5423,27343,54107,5425,56655,57804,23583,2237,4350	PCNA,HMGB1,PARP2,APEX1,OGG1,LIG3,APEX2,POLB,POLL,POLE3,POLD2,POLE4,POLD4,SMUG1,FEN1,MPG
ko03410	Base excision repair	0.0660608486875016	-2.71717901187977	33	16	0.00649614291514413	2463	7161	4350,2237,23583,56655,57804,54107,5425,5423,27343,27301,3980,10038,328,4968,3146,5111	MPG,FEN1,SMUG1,POLE4,POLD4,POLE3,POLD2,POLB,POLL,APEX2,LIG3,PARP2,APEX1,OGG1,HMGB1,PCNA
hsa00520	Amino sugar and nucleotide sugar metabolism	0.0660933195937979	-2.7166876023787	48	22	0.00893219650832318	2463	7161	6675,2762,7358,140838,5236,3073,7264,55907,64841,29926,10007,2673,51167,132789,7360,3074,5373,8790,2582,51706,1727,29925	UAP1,GMDS,UGDH,NANP,PGM1,HEXA,GFUS,CMAS,GNPNAT1,GMPPA,GNPDA1,GFPT1,CYB5R4,GNPDA2,UGP2,HEXB,PMM2,FPGT,GALE,CYB5R1,CYB5R3,GMPPB
ko00520	Amino sugar and nucleotide sugar metabolism	0.0660933195937979	-2.7166876023787	48	22	0.00893219650832318	2463	7161	55907,64841,7264,5236,3073,2762,140838,7358,6675,29925,51706,2582,1727,3074,7360,8790,5373,10007,29926,2673,51167,132789	CMAS,GNPNAT1,GFUS,PGM1,HEXA,GMDS,NANP,UGDH,UAP1,GMPPB,CYB5R1,GALE,CYB5R3,HEXB,UGP2,FPGT,PMM2,GNPDA1,GMPPA,GFPT1,CYB5R4,GNPDA2
hsa05152	Tuberculosis	0.0702260382668675	-2.65603612124007	178	71	0.0288266341859521	2463	7161	51135,5878,207,3717,1054,929,7043,1509,10333,3606,7099,2212,5602,64581,1387,2209,3459,3593,6772,533,208,572,3329,7124,4801,3447,7421,3553,581,820,7097,818,2207,3458,8625,51806,1385,56848,6850,7042,5894,2213,5994,3440,3716,4360,6714,3592,5868,2033,5535,114609,51561,3920,4790,3446,4615,5530,3456,10000,7189,5993,4800,7096,3569,8915,3552,30835,3586,1594,54106	IRAK4,RAB5C,AKT1,JAK2,CEBPG,CD14,TGFB3,CTSD,TLR6,IL18,TLR4,FCGR2A,MAPK10,CLEC7A,CREBBP,FCGR1A,IFNGR1,IL12B,STAT1,ATP6V0B,AKT2,BAD,HSPD1,TNF,NFYB,IFNA13,VDR,IL1B,BAX,CAMP,TLR2,CAMK2G,FCER1G,IFNG,RFXANK,CALML5,CREB1,SPHK2,SYK,TGFB2,RAF1,FCGR2B,RFXAP,IFNA2,JAK1,MRC1,SRC,IL12A,RAB5A,EP300,PPP3R2,TIRAP,IL23A,LAMP2,NFKB1,IFNA10,MYD88,PPP3CA,IFNB1,AKT3,TRAF6,RFX5,NFYA,TLR1,IL6,BCL10,IL1A,CD209,IL10,CYP27B1,TLR9
ko05152	Tuberculosis	0.0702260382668675	-2.65603612124007	178	71	0.0288266341859521	2463	7161	6714,3592,5868,2033,5535,114609,51561,5894,2213,3440,5994,3716,4360,56848,1385,6850,7042,3458,8625,51806,30835,3586,1594,54106,8915,3569,3552,7189,5993,4800,7096,3920,4790,3446,4615,5530,3456,10000,3459,3593,10333,7099,3606,2212,5602,1387,2209,64581,929,7043,1509,51135,5878,207,3717,1054,7097,818,2207,7124,3329,572,4801,7421,3447,3553,820,581,6772,533,208	SRC,IL12A,RAB5A,EP300,PPP3R2,TIRAP,IL23A,RAF1,FCGR2B,IFNA2,RFXAP,JAK1,MRC1,SPHK2,CREB1,SYK,TGFB2,IFNG,RFXANK,CALML5,CD209,IL10,CYP27B1,TLR9,BCL10,IL6,IL1A,TRAF6,RFX5,NFYA,TLR1,LAMP2,NFKB1,IFNA10,MYD88,PPP3CA,IFNB1,AKT3,IFNGR1,IL12B,TLR6,TLR4,IL18,FCGR2A,MAPK10,CREBBP,FCGR1A,CLEC7A,CD14,TGFB3,CTSD,IRAK4,RAB5C,AKT1,JAK2,CEBPG,TLR2,CAMK2G,FCER1G,TNF,HSPD1,BAD,NFYB,VDR,IFNA13,IL1B,CAMP,BAX,STAT1,ATP6V0B,AKT2
ko05214	Glioma	0.0751540369553207	-2.58821544559227	64	28	0.0113682501015022	2463	7161	10000,1026,5579,1019,208,5604,3479,5290,6655,5578,818,8503,5296,7157,51806,207,1021,5295,53358,3845,5728,4193,3480,595,5925,5894,6464,3265	AKT3,CDKN1A,PRKCB,CDK4,AKT2,MAP2K1,IGF1,PIK3CA,SOS2,PRKCA,CAMK2G,PIK3R3,PIK3R2,TP53,CALML5,AKT1,CDK6,PIK3R1,SHC3,KRAS,PTEN,MDM2,IGF1R,CCND1,RB1,RAF1,SHC1,HRAS
hsa05214	Glioma	0.0751540369553207	-2.58821544559227	64	28	0.0113682501015022	2463	7161	595,5925,5894,4193,3480,3265,6464,207,5296,7157,51806,53358,3845,5728,5295,1021,5290,6655,3479,5578,818,8503,5579,1026,10000,208,5604,1019	CCND1,RB1,RAF1,MDM2,IGF1R,HRAS,SHC1,AKT1,PIK3R2,TP53,CALML5,SHC3,KRAS,PTEN,PIK3R1,CDK6,PIK3CA,SOS2,IGF1,PRKCA,CAMK2G,PIK3R3,PRKCB,CDKN1A,AKT3,AKT2,MAP2K1,CDK4
hsa_M00290	Holo-TFIIH complex	0.0775044443971449	-2.55741999720718	12	7	0.00284206252537556	2463	7161	2071,404672,2968,4331,1022,902,2966	ERCC3,GTF2H5,GTF2H4,MNAT1,CDK7,CCNH,GTF2H2
M00290	Holo-TFIIH complex	0.0775044443971449	-2.55741999720718	12	7	0.00284206252537556	2463	7161	2071,1022,4331,2968,404672,2966,902	ERCC3,CDK7,MNAT1,GTF2H4,GTF2H5,GTF2H2,CCNH
hsa_M00388	ECS complex	0.0775044443971449	-2.55741999720718	12	7	0.00284206252537556	2463	7161	9021,9616,122809,8835,1154,6921,9655	SOCS3,RNF7,SOCS4,SOCS2,CISH,ELOC,SOCS5
M00388	ECS complex	0.0775044443971449	-2.55741999720718	12	7	0.00284206252537556	2463	7161	9616,9021,122809,8835,9655,6921,1154	RNF7,SOCS3,SOCS4,SOCS2,SOCS5,ELOC,CISH
ko05140	Leishmaniasis	0.0778959469019187	-2.55238135695942	72	31	0.0125862768980918	2463	7161	2209,3716,2212,7099,4793,4792,3459,3593,3592,3565,3717,51135,3458,2353,7042,7043,3552,3553,7124,10454,23118,3586,7097,4615,65108,4790,5579,2002,3725,7189,6772	FCGR1A,JAK1,FCGR2A,TLR4,NFKBIB,NFKBIA,IFNGR1,IL12B,IL12A,IL4,JAK2,IRAK4,IFNG,FOS,TGFB2,TGFB3,IL1A,IL1B,TNF,TAB1,TAB2,IL10,TLR2,MYD88,MARCKSL1,NFKB1,PRKCB,ELK1,JUN,TRAF6,STAT1
hsa05140	Leishmaniasis	0.0778959469019187	-2.55238135695942	72	31	0.0125862768980918	2463	7161	7043,7042,2353,3458,51135,3565,3717,4792,4793,3593,3592,3459,3716,2209,7099,2212,6772,7189,3725,2002,65108,4615,5579,4790,10454,7097,23118,3586,3552,3553,7124	TGFB3,TGFB2,FOS,IFNG,IRAK4,IL4,JAK2,NFKBIA,NFKBIB,IL12B,IL12A,IFNGR1,JAK1,FCGR1A,TLR4,FCGR2A,STAT1,TRAF6,JUN,ELK1,MARCKSL1,MYD88,PRKCB,NFKB1,TAB1,TLR2,TAB2,IL10,IL1A,IL1B,TNF
hsa04664	Fc epsilon RI signaling pathway	0.0808890232271061	-2.51467714734839	67	29	0.0117742590336987	2463	7161	5296,241,3565,207,3562,1437,5295,6850,3845,5602,3596,5894,7410,100137049,3567,5606,3265,10000,208,5604,3937,5290,7124,6655,2207,5880,5578,5608,8503	PIK3R2,ALOX5AP,IL4,AKT1,IL3,CSF2,PIK3R1,SYK,KRAS,MAPK10,IL13,RAF1,VAV2,PLA2G4B,IL5,MAP2K3,HRAS,AKT3,AKT2,MAP2K1,LCP2,PIK3CA,TNF,SOS2,FCER1G,RAC2,PRKCA,MAP2K6,PIK3R3
ko04664	Fc epsilon RI signaling pathway	0.0808890232271061	-2.51467714734839	67	29	0.0117742590336987	2463	7161	100137049,7410,5606,3567,3265,5602,3596,5894,1437,5295,6850,3845,241,5296,3565,3562,207,2207,5608,5880,5578,8503,3937,5290,6655,7124,208,5604,10000	PLA2G4B,VAV2,MAP2K3,IL5,HRAS,MAPK10,IL13,RAF1,CSF2,PIK3R1,SYK,KRAS,ALOX5AP,PIK3R2,IL4,IL3,AKT1,FCER1G,MAP2K6,RAC2,PRKCA,PIK3R3,LCP2,PIK3CA,SOS2,TNF,AKT2,MAP2K1,AKT3
ko04621	NOD-like receptor signaling pathway	0.0859896568242419	-2.45352825944714	169	67	0.0272025984571661	2463	7161	6352,7189,6773,10616,7295,11345,3446,7128,4790,3456,4615,10628,3320,29108,7417,10454,837,3569,57506,3326,2919,4792,3661,3576,1508,3716,3440,55054,3725,6772,7416,100506742,148022,11337,2921,29110,6041,10010,23118,114548,171389,3665,6347,23710,7124,820,3553,3447,4938,10379,55669,5330,152138,51135,4793,23236,140609,22861,3454,3606,7099,3428,7186,329,598,5602,3551	CCL5,TRAF6,STAT2,RBCK1,TXN,GABARAPL2,IFNA10,TNFAIP3,NFKB1,IFNB1,MYD88,TXNIP,HSP90AA1,PYCARD,VDAC2,TAB1,CASP4,IL6,MAVS,HSP90AB1,CXCL1,NFKBIA,IRF3,CXCL8,CTSB,JAK1,IFNA2,ATG16L1,JUN,STAT1,VDAC1,CASP12,TICAM1,GABARAP,CXCL3,TBK1,RNASEL,TANK,TAB2,NLRP3,NLRP6,IRF7,CCL2,GABARAPL1,TNF,CAMP,IL1B,IFNA13,OAS1,IRF9,MFN1,PLCB2,PYDC2,IRAK4,NFKBIB,PLCB1,NEK7,NLRP1,IFNAR1,IL18,TLR4,IFI16,TRAF2,BIRC2,BCL2L1,MAPK10,IKBKB
hsa04621	NOD-like receptor signaling pathway	0.0859896568242419	-2.45352825944714	169	67	0.0272025984571661	2463	7161	3569,837,3320,10628,10454,7417,29108,4790,3446,7128,4615,3456,10616,6773,7189,6352,11345,7295,3576,3440,3716,1508,3661,4792,2919,57506,3326,7124,23710,6347,3447,3553,820,114548,23118,10010,6041,3665,171389,2921,148022,11337,29110,7416,6772,55054,3725,100506742,7099,3606,3454,22861,140609,3551,5602,598,3428,7186,329,23236,4793,51135,152138,5330,4938,55669,10379	IL6,CASP4,HSP90AA1,TXNIP,TAB1,VDAC2,PYCARD,NFKB1,IFNA10,TNFAIP3,MYD88,IFNB1,RBCK1,STAT2,TRAF6,CCL5,GABARAPL2,TXN,CXCL8,IFNA2,JAK1,CTSB,IRF3,NFKBIA,CXCL1,MAVS,HSP90AB1,TNF,GABARAPL1,CCL2,IFNA13,IL1B,CAMP,NLRP3,TAB2,TANK,RNASEL,IRF7,NLRP6,CXCL3,TICAM1,GABARAP,TBK1,VDAC1,STAT1,ATG16L1,JUN,CASP12,TLR4,IL18,IFNAR1,NLRP1,NEK7,IKBKB,MAPK10,BCL2L1,IFI16,TRAF2,BIRC2,PLCB1,NFKBIB,IRAK4,PYDC2,PLCB2,OAS1,MFN1,IRF9
hsa_M00296	BER complex	0.0878086820822701	-2.43259489846595	10	6	0.00243605359317905	2463	7161	27343,5423,3980,27301,328,10038	POLL,POLB,LIG3,APEX2,APEX1,PARP2
M00152	Cytochrome bc1 complex	0.0878086820822701	-2.43259489846595	10	6	0.00243605359317905	2463	7161	10975,1537,7388,27089,7384,7385	UQCR11,CYC1,UQCRH,UQCRQ,UQCRC1,UQCRC2
M00296	BER complex	0.0878086820822701	-2.43259489846595	10	6	0.00243605359317905	2463	7161	3980,27301,5423,27343,10038,328	LIG3,APEX2,POLB,POLL,PARP2,APEX1
hsa_M00152	Cytochrome bc1 complex	0.0878086820822701	-2.43259489846595	10	6	0.00243605359317905	2463	7161	10975,7384,7388,27089,1537,7385	UQCR11,UQCRC1,UQCRH,UQCRQ,CYC1,UQCRC2
hsa04672	Intestinal immune network for IgA production	0.0924744650747585	-2.38082272581932	47	21	0.00852618757612668	2463	7161	4055,941,3600,8741,3565,7852,29851,3567,958,8174,3586,3601,3558,6370,56477,940,3569,9020,6387,959,942	LTBR,CD80,IL15,TNFSF13,IL4,CXCR4,ICOS,IL5,CD40,MADCAM1,IL10,IL15RA,IL2,CCL25,CCL28,CD28,IL6,MAP3K14,CXCL12,CD40LG,CD86
ko04672	Intestinal immune network for IgA production	0.0924744650747585	-2.38082272581932	47	21	0.00852618757612668	2463	7161	4055,941,3600,8741,3565,7852,29851,3567,8174,958,3586,3601,3558,6370,56477,940,3569,9020,6387,959,942	LTBR,CD80,IL15,TNFSF13,IL4,CXCR4,ICOS,IL5,MADCAM1,CD40,IL10,IL15RA,IL2,CCL25,CCL28,CD28,IL6,MAP3K14,CXCL12,CD40LG,CD86
ko05221	Acute myeloid leukemia	0.097193297245389	-2.33105352827425	55	24	0.0097442143727162	2463	7161	3815,208,5604,10000,4609,4790,861,6776,7704,8503,11040,5290,6655,572,5295,3845,5296,3728,207,3265,3551,595,5371,5894	KIT,AKT2,MAP2K1,AKT3,MYC,NFKB1,RUNX1,STAT5A,ZBTB16,PIK3R3,PIM2,PIK3CA,SOS2,BAD,PIK3R1,KRAS,PIK3R2,JUP,AKT1,HRAS,IKBKB,CCND1,PML,RAF1
hsa05221	Acute myeloid leukemia	0.097193297245389	-2.33105352827425	55	24	0.0097442143727162	2463	7161	7704,3265,8503,3551,11040,5290,595,5894,5371,572,6655,5295,3815,208,3845,5604,10000,3728,5296,4790,4609,861,6776,207	ZBTB16,HRAS,PIK3R3,IKBKB,PIM2,PIK3CA,CCND1,RAF1,PML,BAD,SOS2,PIK3R1,KIT,AKT2,KRAS,MAP2K1,AKT3,JUP,PIK3R2,NFKB1,MYC,RUNX1,STAT5A,AKT1
hsa05100	Bacterial invasion of epithelial cells	0.0978010878377311	-2.32481957891804	76	32	0.0129922858302883	2463	7161	1785,63916,23607,10109,867,9844,1499,10459,8976,5290,391,60,858,8503,2017,23157,5296,998,4233,5295,3611,53358,1399,1496,3059,857,859,10094,6464,1495,6714,2549	DNM2,ELMO2,CD2AP,ARPC2,CBL,ELMO1,CTNNB1,MAD2L2,WASL,PIK3CA,RHOG,ACTB,CAV2,PIK3R3,CTTN,SEPTIN6,PIK3R2,CDC42,MET,PIK3R1,ILK,SHC3,CRKL,CTNNA2,HCLS1,CAV1,CAV3,ARPC3,SHC1,CTNNA1,SRC,GAB1
ko05100	Bacterial invasion of epithelial cells	0.0978010878377311	-2.32481957891804	76	32	0.0129922858302883	2463	7161	6464,10094,1495,6714,2549,1496,1399,859,857,3059,5295,53358,3611,23157,5296,998,2017,4233,60,391,858,8503,10459,8976,5290,10109,867,23607,1499,9844,1785,63916	SHC1,ARPC3,CTNNA1,SRC,GAB1,CTNNA2,CRKL,CAV3,CAV1,HCLS1,PIK3R1,SHC3,ILK,SEPTIN6,PIK3R2,CDC42,CTTN,MET,ACTB,RHOG,CAV2,PIK3R3,MAD2L2,WASL,PIK3CA,ARPC2,CBL,CD2AP,CTNNB1,ELMO1,DNM2,ELMO2
ko05213	Endometrial cancer	0.100701055106268	-2.29559900159387	50	22	0.00893219650832318	2463	7161	4609,10000,2002,208,5604,1499,5290,572,6655,8503,207,5296,7157,3611,5728,3845,5295,595,5894,1496,3265,1495	MYC,AKT3,ELK1,AKT2,MAP2K1,CTNNB1,PIK3CA,BAD,SOS2,PIK3R3,AKT1,PIK3R2,TP53,ILK,PTEN,KRAS,PIK3R1,CCND1,RAF1,CTNNA2,HRAS,CTNNA1
hsa05213	Endometrial cancer	0.100701055106268	-2.29559900159387	50	22	0.00893219650832318	2463	7161	595,5290,6655,572,5894,1496,8503,3265,1495,4609,207,10000,5296,7157,208,3611,2002,1499,5604,3845,5728,5295	CCND1,PIK3CA,SOS2,BAD,RAF1,CTNNA2,PIK3R3,HRAS,CTNNA1,MYC,AKT1,AKT3,PIK3R2,TP53,AKT2,ILK,ELK1,CTNNB1,MAP2K1,KRAS,PTEN,PIK3R1
ko00604	Glycosphingolipid biosynthesis - ganglio series	0.10344153772357	-2.26874867877858	15	8	0.00324807145757207	2463	7161	256435,3073,3074,8869,29906,6483,6482,8705	ST6GALNAC3,HEXA,HEXB,ST3GAL5,ST8SIA5,ST3GAL2,ST3GAL1,B3GALT4
hsa00604	Glycosphingolipid biosynthesis - ganglio series	0.10344153772357	-2.26874867877858	15	8	0.00324807145757207	2463	7161	3073,256435,6483,6482,29906,8705,8869,3074	HEXA,ST6GALNAC3,ST3GAL2,ST3GAL1,ST8SIA5,B3GALT4,ST3GAL5,HEXB
ko01522	Endocrine resistance	0.103662803828397	-2.26661191827076	95	39	0.0158343483556638	2463	7161	5894,5567,4318,595,5925,3480,4193,5602,6714,3265,6667,6464,1565,207,4853,109,5296,7157,1839,2100,53358,3845,5295,2353,6655,572,1027,5290,3479,581,8503,1031,1026,10000,5604,208,108,3725,1019	RAF1,PRKACB,MMP9,CCND1,RB1,IGF1R,MDM2,MAPK10,SRC,HRAS,SP1,SHC1,CYP2D6,AKT1,NOTCH2,ADCY3,PIK3R2,TP53,HBEGF,ESR2,SHC3,KRAS,PIK3R1,FOS,SOS2,BAD,CDKN1B,PIK3CA,IGF1,BAX,PIK3R3,CDKN2C,CDKN1A,AKT3,MAP2K1,AKT2,ADCY2,JUN,CDK4
hsa01522	Endocrine resistance	0.103662803828397	-2.26661191827076	95	39	0.0158343483556638	2463	7161	8503,1031,3479,581,572,6655,1027,5290,1019,5604,208,3725,108,10000,1026,6464,1565,6714,3265,6667,3480,4193,5602,5894,5567,4318,595,5925,5295,2353,53358,3845,7157,5296,1839,2100,207,109,4853	PIK3R3,CDKN2C,IGF1,BAX,BAD,SOS2,CDKN1B,PIK3CA,CDK4,MAP2K1,AKT2,JUN,ADCY2,AKT3,CDKN1A,SHC1,CYP2D6,SRC,HRAS,SP1,IGF1R,MDM2,MAPK10,RAF1,PRKACB,MMP9,CCND1,RB1,PIK3R1,FOS,SHC3,KRAS,TP53,PIK3R2,HBEGF,ESR2,AKT1,ADCY3,NOTCH2
ko04216	Ferroptosis	0.107171712630789	-2.23332293987929	40	18	0.00730816077953715	2463	7161	7037,23657,81631,10533,5621,2495,7417,84557,6303,7018,7157,112483,2729,4891,2182,10162,2879,2512	TFRC,SLC7A11,MAP1LC3B,ATG7,PRNP,FTH1,VDAC2,MAP1LC3A,SAT1,TF,TP53,SAT2,GCLC,SLC11A2,ACSL4,LPCAT3,GPX4,FTL
hsa04216	Ferroptosis	0.107171712630789	-2.23332293987929	40	18	0.00730816077953715	2463	7161	2495,7417,6303,84557,7037,5621,10533,81631,23657,2182,4891,2512,2879,10162,7157,7018,112483,2729	FTH1,VDAC2,SAT1,MAP1LC3A,TFRC,PRNP,ATG7,MAP1LC3B,SLC7A11,ACSL4,SLC11A2,FTL,GPX4,LPCAT3,TP53,TF,SAT2,GCLC
ko05204	Chemical carcinogenesis	0.108763790550505	-2.21857680739319	82	34	0.0138043036946813	2463	7161	124,54658,2949,125,2950,1545,1543,2941,64816,220,79799,2052,6818,27306,3290,1139,2948,9446,2939,1558,119391,2947,4258,2952,4259,2938,653689,1577,10,1646,2946,1562,373156,1559	ADH1A,UGT1A1,GSTM5,ADH1B,GSTP1,CYP1B1,CYP1A1,GSTA4,CYP3A43,ALDH1A3,UGT2A3,EPHX1,SULT1A3,HPGDS,HSD11B1,CHRNA7,GSTM4,GSTO1,GSTA2,CYP2C8,GSTO2,GSTM3,MGST2,GSTT1,MGST3,GSTA1,GSTT2B,CYP3A5,NAT2,AKR1C2,GSTM2,CYP2C18,GSTK1,CYP2C9
hsa05204	Chemical carcinogenesis	0.108763790550505	-2.21857680739319	82	34	0.0138043036946813	2463	7161	4259,2952,653689,1577,2938,1646,2946,10,1559,373156,1562,2939,1558,119391,4258,2947,2941,220,64816,79799,6818,2052,27306,2948,3290,1139,9446,54658,124,2949,125,2950,1545,1543	MGST3,GSTT1,GSTT2B,CYP3A5,GSTA1,AKR1C2,GSTM2,NAT2,CYP2C9,GSTK1,CYP2C18,GSTA2,CYP2C8,GSTO2,MGST2,GSTM3,GSTA4,ALDH1A3,CYP3A43,UGT2A3,SULT1A3,EPHX1,HPGDS,GSTM4,HSD11B1,CHRNA7,GSTO1,UGT1A1,ADH1A,GSTM5,ADH1B,GSTP1,CYP1B1,CYP1A1
hsa_M00058	Glycosaminoglycan biosynthesis, chondroitin sulfate backbone	0.110859742995291	-2.19948945327486	6	4	0.00162403572878603	2463	7161	79586,55454,54480,55790	CHPF,CSGALNACT2,CHPF2,CSGALNACT1
hsa_M00085	Fatty acid biosynthesis, elongation, mitochondria	0.110859742995291	-2.19948945327486	6	4	0.00162403572878603	2463	7161	10449,3030,3033,51102	ACAA2,HADHA,HADH,MECR
M00058	Glycosaminoglycan biosynthesis, chondroitin sulfate backbone	0.110859742995291	-2.19948945327486	6	4	0.00162403572878603	2463	7161	55790,54480,55454,79586	CSGALNACT1,CHPF2,CSGALNACT2,CHPF
M00085	Fatty acid biosynthesis, elongation, mitochondria	0.110859742995291	-2.19948945327486	6	4	0.00162403572878603	2463	7161	3033,51102,10449,3030	HADH,MECR,ACAA2,HADHA
ko04115	p53 signaling pathway	0.113305883028272	-2.17766418795134	69	29	0.0117742590336987	2463	7161	1021,1647,2810,5728,64393,7157,56475,8493,83667,4193,143686,9540,595,4616,25898,10912,1019,983,1026,9538,6477,355,5366,3486,891,3479,896,581,64326	CDK6,GADD45A,SFN,PTEN,ZMAT3,TP53,RPRM,PPM1D,SESN2,MDM2,SESN3,TP53I3,CCND1,GADD45B,RCHY1,GADD45G,CDK4,CDK1,CDKN1A,EI24,SIAH1,FAS,PMAIP1,IGFBP3,CCNB1,IGF1,CCND3,BAX,COP1
hsa00982	Drug metabolism - cytochrome P450	0.113305883028272	-2.17766418795134	69	29	0.0117742590336987	2463	7161	1558,2327,2939,2947,4258,119391,316,2952,4259,2326,1565,373156,1559,653689,1577,2938,2946,2949,125,54658,124,2950,220,79799,2328,2941,2948,9446,27306	CYP2C8,FMO2,GSTA2,GSTM3,MGST2,GSTO2,AOX1,GSTT1,MGST3,FMO1,CYP2D6,GSTK1,CYP2C9,GSTT2B,CYP3A5,GSTA1,GSTM2,GSTM5,ADH1B,UGT1A1,ADH1A,GSTP1,ALDH1A3,UGT2A3,FMO3,GSTA4,GSTM4,GSTO1,HPGDS
ko00982	Drug metabolism - cytochrome P450	0.113305883028272	-2.17766418795134	69	29	0.0117742590336987	2463	7161	125,2949,54658,124,2950,220,79799,2328,2941,2948,9446,27306,2327,1558,2939,4258,2947,119391,316,2952,4259,2326,1565,1559,373156,1577,653689,2938,2946	ADH1B,GSTM5,UGT1A1,ADH1A,GSTP1,ALDH1A3,UGT2A3,FMO3,GSTA4,GSTM4,GSTO1,HPGDS,FMO2,CYP2C8,GSTA2,MGST2,GSTM3,GSTO2,AOX1,GSTT1,MGST3,FMO1,CYP2D6,CYP2C9,GSTK1,CYP3A5,GSTT2B,GSTA1,GSTM2
hsa04115	p53 signaling pathway	0.113305883028272	-2.17766418795134	69	29	0.0117742590336987	2463	7161	3479,896,581,64326,1026,9538,6477,983,3486,891,5366,355,10912,1019,25898,4616,4193,143686,9540,595,8493,83667,7157,56475,1647,2810,1021,64393,5728	IGF1,CCND3,BAX,COP1,CDKN1A,EI24,SIAH1,CDK1,IGFBP3,CCNB1,PMAIP1,FAS,GADD45G,CDK4,RCHY1,GADD45B,MDM2,SESN3,TP53I3,CCND1,PPM1D,SESN2,TP53,RPRM,GADD45A,SFN,CDK6,ZMAT3,PTEN
M00066	Lactosylceramide biosynthesis	0.118267594721427	-2.1348054701084	2	2	0.000812017864393017	2463	7161	9331,7357	B4GALT6,UGCG
hsa_M00103	Cholecalciferol biosynthesis	0.118267594721427	-2.1348054701084	2	2	0.000812017864393017	2463	7161	1594,120227	CYP27B1,CYP2R1
M00103	Cholecalciferol biosynthesis	0.118267594721427	-2.1348054701084	2	2	0.000812017864393017	2463	7161	120227,1594	CYP2R1,CYP27B1
hsa_M00066	Lactosylceramide biosynthesis	0.118267594721427	-2.1348054701084	2	2	0.000812017864393017	2463	7161	9331,7357	B4GALT6,UGCG
M00403	HRD1/SEL1 ERAD complex	0.119420758866336	-2.12510223328345	13	7	0.00284206252537556	2463	7161	55829,10956,84447,27248,79139,7353,51009	SELENOS,OS9,SYVN1,ERLEC1,DERL1,UFD1,DERL2
M00676	PI3K-Akt signaling	0.119420758866336	-2.12510223328345	13	7	0.00284206252537556	2463	7161	10000,5296,5295,208,5290,207,8503	AKT3,PIK3R2,PIK3R1,AKT2,PIK3CA,AKT1,PIK3R3
hsa_M00403	HRD1/SEL1 ERAD complex	0.119420758866336	-2.12510223328345	13	7	0.00284206252537556	2463	7161	84447,10956,55829,79139,27248,51009,7353	SYVN1,OS9,SELENOS,DERL1,ERLEC1,DERL2,UFD1
hsa_M00676	PI3K-Akt signaling	0.119420758866336	-2.12510223328345	13	7	0.00284206252537556	2463	7161	8503,207,5290,208,5295,5296,10000	PIK3R3,AKT1,PIK3CA,AKT2,PIK3R1,PIK3R2,AKT3
M00384	Cul3-SPOP complex	0.120707186935503	-2.11438760886089	4	3	0.00121802679658952	2463	7161	8452,8405,339745	CUL3,SPOP,SPOPL
hsa_M00402	Translocon-associated protein (TRAP) complex	0.120707186935503	-2.11438760886089	4	3	0.00121802679658952	2463	7161	6747,6746,6745	SSR3,SSR2,SSR1
hsa_M00384	Cul3-SPOP complex	0.120707186935503	-2.11438760886089	4	3	0.00121802679658952	2463	7161	339745,8405,8452	SPOPL,SPOP,CUL3
M00402	Translocon-associated protein (TRAP) complex	0.120707186935503	-2.11438760886089	4	3	0.00121802679658952	2463	7161	6747,6746,6745	SSR3,SSR2,SSR1
hsa05014	Amyotrophic lateral sclerosis (ALS)	0.121655605618188	-2.10656113092779	51	22	0.00893219650832318	2463	7161	10452,5530,100506742,6647,4747,581,2876,7124,572,7133,5608,9973,7157,2890,79139,598,6506,84134,5606,2891,5868,5535	TOMM40,PPP3CA,CASP12,SOD1,NEFL,BAX,GPX1,TNF,BAD,TNFRSF1B,MAP2K6,CCS,TP53,GRIA1,DERL1,BCL2L1,SLC1A2,TOMM40L,MAP2K3,GRIA2,RAB5A,PPP3R2
ko05014	Amyotrophic lateral sclerosis (ALS)	0.121655605618188	-2.10656113092779	51	22	0.00893219650832318	2463	7161	84134,7124,572,581,598,6506,2876,5868,9973,5608,5535,7133,2891,5606,2890,10452,7157,5530,6647,4747,79139,100506742	TOMM40L,TNF,BAD,BAX,BCL2L1,SLC1A2,GPX1,RAB5A,CCS,MAP2K6,PPP3R2,TNFRSF1B,GRIA2,MAP2K3,GRIA1,TOMM40,TP53,PPP3CA,SOD1,NEFL,DERL1,CASP12
ko05110	Vibrio cholerae infection	0.121655605618188	-2.10656113092779	51	22	0.00893219650832318	2463	7161	109,55176,1080,6558,30001,375,533,534,51382,10952,528,29927,10945,5567,90423,523,9550,23480,8992,11014,5578,60	ADCY3,SEC61A2,CFTR,SLC12A2,ERO1A,ARF1,ATP6V0B,ATP6V1G2,ATP6V1D,SEC61B,ATP6V1C1,SEC61A1,KDELR1,PRKACB,ATP6V1E2,ATP6V1A,ATP6V1G1,SEC61G,ATP6V0E1,KDELR2,PRKCA,ACTB
hsa05110	Vibrio cholerae infection	0.121655605618188	-2.10656113092779	51	22	0.00893219650832318	2463	7161	528,10945,90423,5578,8992,60,6558,30001,533,375,51382,29927,5567,523,23480,9550,11014,1080,55176,109,534,10952	ATP6V1C1,KDELR1,ATP6V1E2,PRKCA,ATP6V0E1,ACTB,SLC12A2,ERO1A,ATP6V0B,ARF1,ATP6V1D,SEC61A1,PRKACB,ATP6V1A,SEC61G,ATP6V1G1,KDELR2,CFTR,SEC61A2,ADCY3,ATP6V1G2,SEC61B
hsa04659	Th17 cell differentiation	0.121979824729026	-2.10389961899774	107	43	0.0174583840844499	2463	7161	3725,6772,861,6776,3662,112744,3560,50616,59067,3553,6778,3717,4088,3565,3559,4793,3459,5602,3551,5530,4790,7048,3561,3556,6258,3320,3569,920,4087,50943,2353,3326,3458,51561,4792,3572,5535,4089,3558,3716,917,919,5588	JUN,STAT1,RUNX1,STAT5A,IRF4,IL17F,IL2RB,IL22,IL21,IL1B,STAT6,JAK2,SMAD3,IL4,IL2RA,NFKBIB,IFNGR1,MAPK10,IKBKB,PPP3CA,NFKB1,TGFBR2,IL2RG,IL1RAP,RXRG,HSP90AA1,IL6,CD4,SMAD2,FOXP3,FOS,HSP90AB1,IFNG,IL23A,NFKBIA,IL6ST,PPP3R2,SMAD4,IL2,JAK1,CD3G,CD247,PRKCQ
ko04659	Th17 cell differentiation	0.121979824729026	-2.10389961899774	107	43	0.0174583840844499	2463	7161	3556,3320,6258,920,3569,4087,50943,5530,7048,3561,4790,51561,4792,3558,3572,4089,5535,3716,5588,919,917,2353,3326,3458,112744,3560,3662,50616,3553,59067,6772,3725,6776,861,4793,3459,3551,5602,6778,3559,3565,4088,3717	IL1RAP,HSP90AA1,RXRG,CD4,IL6,SMAD2,FOXP3,PPP3CA,TGFBR2,IL2RG,NFKB1,IL23A,NFKBIA,IL2,IL6ST,SMAD4,PPP3R2,JAK1,PRKCQ,CD247,CD3G,FOS,HSP90AB1,IFNG,IL17F,IL2RB,IRF4,IL22,IL1B,IL21,STAT1,JUN,STAT5A,RUNX1,NFKBIB,IFNGR1,IKBKB,MAPK10,STAT6,IL2RA,IL4,SMAD3,JAK2
hsa04071	Sphingolipid signaling pathway	0.124467920589334	-2.08370726222807	118	47	0.0190824198132359	2463	7161	10000,4790,8560,5523,5604,140,5518,5578,2776,166929,7157,56848,5516,5894,134,9475,5529,3265,5579,6610,5522,2771,5525,208,581,6093,5290,7124,29956,259230,2207,5880,8503,5296,5330,207,1509,2773,5295,5728,3845,7186,5602,8698,253782,23236,5581	AKT3,NFKB1,DEGS1,PPP2R3A,MAP2K1,ADORA3,PPP2R1A,PRKCA,GNAQ,SGMS2,TP53,SPHK2,PPP2CB,RAF1,ADORA1,ROCK2,PPP2R5E,HRAS,PRKCB,SMPD2,PPP2R2C,GNAI2,PPP2R5A,AKT2,BAX,ROCK1,PIK3CA,TNF,CERS2,SGMS1,FCER1G,RAC2,PIK3R3,PIK3R2,PLCB2,AKT1,CTSD,GNAI3,PIK3R1,PTEN,KRAS,TRAF2,MAPK10,S1PR4,CERS6,PLCB1,PRKCE
ko04071	Sphingolipid signaling pathway	0.124467920589334	-2.08370726222807	118	47	0.0190824198132359	2463	7161	56848,7157,166929,2776,3265,5529,9475,134,5894,5516,5604,5523,8560,4790,10000,5578,5518,140,5728,3845,5295,2773,1509,207,5330,5296,5581,23236,253782,5602,8698,7186,208,2771,5525,6610,5522,5579,8503,5880,2207,259230,29956,7124,5290,6093,581	SPHK2,TP53,SGMS2,GNAQ,HRAS,PPP2R5E,ROCK2,ADORA1,RAF1,PPP2CB,MAP2K1,PPP2R3A,DEGS1,NFKB1,AKT3,PRKCA,PPP2R1A,ADORA3,PTEN,KRAS,PIK3R1,GNAI3,CTSD,AKT1,PLCB2,PIK3R2,PRKCE,PLCB1,CERS6,MAPK10,S1PR4,TRAF2,AKT2,GNAI2,PPP2R5A,SMPD2,PPP2R2C,PRKCB,PIK3R3,RAC2,FCER1G,SGMS1,CERS2,TNF,PIK3CA,ROCK1,BAX
hsa05032	Morphine addiction	0.124663398460206	-2.08213798613919	91	37	0.0150223304912708	2463	7161	5151,2784,134,51764,2562,5136,5567,2554,2566,2550,2788,140679,2775,2793,2773,59345,109,5150,5578,5153,2787,55970,5142,2561,1812,2790,5138,3760,2555,108,4988,2791,54331,2771,5579,2782,2785	PDE8A,GNB3,ADORA1,GNG13,GABRB3,PDE1A,PRKACB,GABRA1,GABRG2,GABBR1,GNG7,SLC32A1,GNAO1,GNGT2,GNAI3,GNB4,ADCY3,PDE7A,PRKCA,PDE1B,GNG5,GNG12,PDE4B,GABRB2,DRD1,GNG10,PDE2A,KCNJ3,GABRA2,ADCY2,OPRM1,GNG11,GNG2,GNAI2,PRKCB,GNB1,GNG3
ko05032	Morphine addiction	0.124663398460206	-2.08213798613919	91	37	0.0150223304912708	2463	7161	108,2555,2791,4988,54331,2771,5579,2782,2785,5578,5153,2787,55970,5142,2561,1812,2790,5138,3760,2788,140679,2793,2775,2773,59345,109,5150,5151,2784,134,51764,2562,5136,5567,2554,2566,2550	ADCY2,GABRA2,GNG11,OPRM1,GNG2,GNAI2,PRKCB,GNB1,GNG3,PRKCA,PDE1B,GNG5,GNG12,PDE4B,GABRB2,DRD1,GNG10,PDE2A,KCNJ3,GNG7,SLC32A1,GNGT2,GNAO1,GNAI3,GNB4,ADCY3,PDE7A,PDE8A,GNB3,ADORA1,GNG13,GABRB3,PDE1A,PRKACB,GABRA1,GABRG2,GABBR1
ko04922	Glucagon signaling pathway	0.128235750885359	-2.05388490531151	102	41	0.0166463662200568	2463	7161	1385,5162,3945,5330,207,2776,200186,51806,2033,5535,3939,23236,5834,92483,5567,5465,468,1387,148327,31,5260,208,108,6513,2203,1375,5255,5106,10000,92579,10488,2997,5530,818,5531,5837,5257,5160,5564,5571,5223	CREB1,PDHB,LDHB,PLCB2,AKT1,GNAQ,CRTC2,CALML5,EP300,PPP3R2,LDHA,PLCB1,PYGB,LDHAL6B,PRKACB,PPARA,ATF4,CREBBP,CREB3L4,ACACA,PHKG1,AKT2,ADCY2,SLC2A1,FBP1,CPT1B,PHKA1,PCK2,AKT3,G6PC3,CREB3,GYS1,PPP3CA,CAMK2G,PPP4C,PYGM,PHKB,PDHA1,PRKAB1,PRKAG1,PGAM1
hsa04922	Glucagon signaling pathway	0.128235750885359	-2.05388490531151	102	41	0.0166463662200568	2463	7161	5567,92483,31,148327,1387,468,5465,5535,2033,5834,23236,3939,207,5330,51806,200186,2776,1385,3945,5162,5160,5564,5223,5571,5531,818,5837,5257,5255,5106,2203,1375,5530,2997,10488,10000,92579,108,208,5260,6513	PRKACB,LDHAL6B,ACACA,CREB3L4,CREBBP,ATF4,PPARA,PPP3R2,EP300,PYGB,PLCB1,LDHA,AKT1,PLCB2,CALML5,CRTC2,GNAQ,CREB1,LDHB,PDHB,PDHA1,PRKAB1,PGAM1,PRKAG1,PPP4C,CAMK2G,PYGM,PHKB,PHKA1,PCK2,FBP1,CPT1B,PPP3CA,GYS1,CREB3,AKT3,G6PC3,ADCY2,AKT2,PHKG1,SLC2A1
hsa05219	Bladder cancer	0.131938936598551	-2.02541606495499	41	18	0.00730816077953715	2463	7161	7422,1612,1613,4193,3576,5894,5925,4318,595,3265,6714,7157,1026,1839,4609,1019,3845,5604	VEGFA,DAPK1,DAPK3,MDM2,CXCL8,RAF1,RB1,MMP9,CCND1,HRAS,SRC,TP53,CDKN1A,HBEGF,MYC,CDK4,KRAS,MAP2K1
ko05219	Bladder cancer	0.131938936598551	-2.02541606495499	41	18	0.00730816077953715	2463	7161	4318,595,5925,5894,3576,1613,1612,4193,7422,6714,3265,4609,1026,1839,7157,5604,3845,1019	MMP9,CCND1,RB1,RAF1,CXCL8,DAPK3,DAPK1,MDM2,VEGFA,SRC,HRAS,MYC,CDKN1A,HBEGF,TP53,MAP2K1,KRAS,CDK4
hsa04211	Longevity regulating pathway	0.136562360256507	-1.99097391698606	89	36	0.0146163215590743	2463	7161	208,108,1977,10000,10488,9821,9470,4790,60673,8503,5468,6009,79602,3479,581,5571,5564,5290,5295,1385,3845,5296,7157,207,109,9370,51094,83667,3265,6648,6794,3480,468,143686,148327,5567	AKT2,ADCY2,EIF4E,AKT3,CREB3,RB1CC1,EIF4E2,NFKB1,ATG101,PIK3R3,PPARG,RHEB,ADIPOR2,IGF1,BAX,PRKAG1,PRKAB1,PIK3CA,PIK3R1,CREB1,KRAS,PIK3R2,TP53,AKT1,ADCY3,ADIPOQ,ADIPOR1,SESN2,HRAS,SOD2,STK11,IGF1R,ATF4,SESN3,CREB3L4,PRKACB
hsa04728	Dopaminergic synapse	0.140724110201333	-1.9609539706129	130	51	0.0207064555420219	2463	7161	2353,2775,6531,2788,84152,1385,5501,2776,50632,51806,59345,2891,51764,5529,468,2931,5516,5567,1312,5523,2782,10000,5530,2785,5578,55970,5518,2790,1812,2793,1814,2773,2890,5330,207,23236,2784,148327,5602,5500,5522,2791,54331,2771,5525,208,10488,5579,818,2787,3760	FOS,GNAO1,SLC6A3,GNG7,PPP1R1B,CREB1,PPP1CC,GNAQ,CALY,CALML5,GNB4,GRIA2,GNG13,PPP2R5E,ATF4,GSK3A,PPP2CB,PRKACB,COMT,PPP2R3A,GNB1,AKT3,PPP3CA,GNG3,PRKCA,GNG12,PPP2R1A,GNG10,DRD1,GNGT2,DRD3,GNAI3,GRIA1,PLCB2,AKT1,PLCB1,GNB3,CREB3L4,MAPK10,PPP1CB,PPP2R2C,GNG11,GNG2,GNAI2,PPP2R5A,AKT2,CREB3,PRKCB,CAMK2G,GNG5,KCNJ3
ko04728	Dopaminergic synapse	0.140724110201333	-1.9609539706129	130	51	0.0207064555420219	2463	7161	10488,5579,54331,5522,2791,5525,2771,208,3760,2787,818,5330,2890,207,2793,2773,1814,148327,5602,5500,23236,2784,2782,10000,2785,5530,5523,1312,5518,2790,1812,5578,55970,2776,50632,51806,59345,2353,2775,6531,2788,84152,5501,1385,2931,468,5516,5567,51764,2891,5529	CREB3,PRKCB,GNG2,PPP2R2C,GNG11,PPP2R5A,GNAI2,AKT2,KCNJ3,GNG5,CAMK2G,PLCB2,GRIA1,AKT1,GNGT2,GNAI3,DRD3,CREB3L4,MAPK10,PPP1CB,PLCB1,GNB3,GNB1,AKT3,GNG3,PPP3CA,PPP2R3A,COMT,PPP2R1A,GNG10,DRD1,PRKCA,GNG12,GNAQ,CALY,CALML5,GNB4,FOS,GNAO1,SLC6A3,GNG7,PPP1R1B,PPP1CC,CREB1,GSK3A,ATF4,PPP2CB,PRKACB,GNG13,GRIA2,PPP2R5E
ko01523	Antifolate resistance	0.141565661954804	-1.95499162744965	31	14	0.00568412505075112	2463	7161	2348,6470,7298,10057,4790,1244,390243,3553,3569,3551,7124,9429,2350,8836	FOLR1,SHMT1,TYMS,ABCC5,NFKB1,ABCC2,IZUMO1R,IL1B,IL6,IKBKB,TNF,ABCG2,FOLR2,GGH
hsa03020	RNA polymerase	0.141565661954804	-1.95499162744965	31	14	0.00568412505075112	2463	7161	5441,30834,5435,10621,5431,55703,5433,5432,5438,5436,84265,84172,171568,51082	POLR2L,POLR1H,POLR2F,POLR3F,POLR2B,POLR3B,POLR2D,POLR2C,POLR2I,POLR2G,POLR3GL,POLR1B,POLR3H,POLR1D
ko03020	RNA polymerase	0.141565661954804	-1.95499162744965	31	14	0.00568412505075112	2463	7161	171568,84265,84172,51082,30834,5435,5432,5433,5431,10621,55703,5441,5436,5438	POLR3H,POLR3GL,POLR1B,POLR1D,POLR1H,POLR2F,POLR2C,POLR2D,POLR2B,POLR3F,POLR3B,POLR2L,POLR2G,POLR2I
hsa01523	Antifolate resistance	0.141565661954804	-1.95499162744965	31	14	0.00568412505075112	2463	7161	8836,3553,3569,3551,2350,9429,7124,390243,1244,2348,6470,4790,10057,7298	GGH,IL1B,IL6,IKBKB,FOLR2,ABCG2,TNF,IZUMO1R,ABCC2,FOLR1,SHMT1,NFKB1,ABCC5,TYMS
ko04730	Long-term depression	0.146100847122788	-1.92345816200281	60	25	0.0101502233049127	2463	7161	2890,5330,2776,2781,2767,3845,2775,2773,2983,5516,5894,2911,3480,10842,3265,2891,23236,100137049,1394,5579,5604,2771,3479,5518,5578	GRIA1,PLCB2,GNAQ,GNAZ,GNA11,KRAS,GNAO1,GNAI3,GUCY1B1,PPP2CB,RAF1,GRM1,IGF1R,PPP1R17,HRAS,GRIA2,PLCB1,PLA2G4B,CRHR1,PRKCB,MAP2K1,GNAI2,IGF1,PPP2R1A,PRKCA
hsa04730	Long-term depression	0.146100847122788	-1.92345816200281	60	25	0.0101502233049127	2463	7161	10842,3265,2891,100137049,23236,1394,2983,5516,5894,2911,3480,2767,3845,2775,2773,2890,5330,2776,2781,5578,3479,5518,5604,2771,5579	PPP1R17,HRAS,GRIA2,PLA2G4B,PLCB1,CRHR1,GUCY1B1,PPP2CB,RAF1,GRM1,IGF1R,GNA11,KRAS,GNAO1,GNAI3,GRIA1,PLCB2,GNAQ,GNAZ,PRKCA,IGF1,PPP2R1A,MAP2K1,GNAI2,PRKCB
M00295	BRCA1-associated genome surveillance complex (BASC)	0.146667048216285	-1.91959023926665	16	8	0.00324807145757207	2463	7161	5985,5982,5983,4683,672,5111,2956,5984	RFC5,RFC2,RFC3,NBN,BRCA1,PCNA,MSH6,RFC4
hsa_M00295	BRCA1-associated genome surveillance complex (BASC)	0.146667048216285	-1.91959023926665	16	8	0.00324807145757207	2463	7161	5985,5983,5982,4683,672,5111,5984,2956	RFC5,RFC3,RFC2,NBN,BRCA1,PCNA,RFC4,MSH6
hsa04670	Leukocyte transendothelial migration	0.146711631645481	-1.9192863083228	114	45	0.0182704019488429	2463	7161	1495,7410,9076,394,5781,1496,4318,5295,2773,81,5296,998,9080,53842,5880,8503,1365,5010,399,5290,6387,6093,3702,2771,50848,5579,9475,23562,5906,7070,9073,3383,90952,1364,1500,60,5578,5908,103910,100132463,9074,1499,10627,4478,7852	CTNNA1,VAV2,CLDN1,ARHGAP5,PTPN11,CTNNA2,MMP9,PIK3R1,GNAI3,ACTN4,PIK3R2,CDC42,CLDN9,CLDN22,RAC2,PIK3R3,CLDN3,CLDN11,RHOH,PIK3CA,CXCL12,ROCK1,ITK,GNAI2,F11R,PRKCB,ROCK2,CLDN14,RAP1A,THY1,CLDN8,ICAM1,ESAM,CLDN4,CTNND1,ACTB,PRKCA,RAP1B,MYL12B,CLDN24,CLDN6,CTNNB1,MYL12A,MSN,CXCR4
ko04670	Leukocyte transendothelial migration	0.146711631645481	-1.9192863083228	114	45	0.0182704019488429	2463	7161	7070,9475,5906,23562,3383,9073,90952,1364,1500,5908,5578,60,103910,1499,9074,100132463,4478,7852,10627,394,7410,1495,9076,4318,5781,1496,81,2773,5295,9080,998,5296,5880,1365,8503,53842,6093,6387,399,5290,5010,3702,2771,5579,50848	THY1,ROCK2,RAP1A,CLDN14,ICAM1,CLDN8,ESAM,CLDN4,CTNND1,RAP1B,PRKCA,ACTB,MYL12B,CTNNB1,CLDN6,CLDN24,MSN,CXCR4,MYL12A,ARHGAP5,VAV2,CTNNA1,CLDN1,MMP9,PTPN11,CTNNA2,ACTN4,GNAI3,PIK3R1,CLDN9,CDC42,PIK3R2,RAC2,CLDN3,PIK3R3,CLDN22,ROCK1,CXCL12,RHOH,PIK3CA,CLDN11,ITK,GNAI2,PRKCB,F11R
hsa03420	Nucleotide excision repair	0.152224693966271	-1.88239759989339	47	20	0.00812017864393017	2463	7161	5985,5983,5982,6118,2966,57804,56655,1022,2968,5425,2071,54107,5887,1069,902,6119,5111,5984,404672,4331	RFC5,RFC3,RFC2,RPA2,GTF2H2,POLD4,POLE4,CDK7,GTF2H4,POLD2,ERCC3,POLE3,RAD23B,CETN2,CCNH,RPA3,PCNA,RFC4,GTF2H5,MNAT1
ko03420	Nucleotide excision repair	0.152224693966271	-1.88239759989339	47	20	0.00812017864393017	2463	7161	2966,56655,57804,1022,2968,5985,6118,5982,5983,6119,5111,1069,902,5887,5984,4331,404672,54107,2071,5425	GTF2H2,POLE4,POLD4,CDK7,GTF2H4,RFC5,RPA2,RFC2,RFC3,RPA3,PCNA,CETN2,CCNH,RAD23B,RFC4,MNAT1,GTF2H5,POLE3,ERCC3,POLD2
ko05223	Non-small cell lung cancer	0.162001539459035	-1.82014944096135	58	24	0.0097442143727162	2463	7161	1021,5295,3845,7157,5296,207,2272,3265,595,5925,5894,1019,208,5604,10000,6776,5579,5578,6258,8503,6789,5290,6655,572	CDK6,PIK3R1,KRAS,TP53,PIK3R2,AKT1,FHIT,HRAS,CCND1,RB1,RAF1,CDK4,AKT2,MAP2K1,AKT3,STAT5A,PRKCB,PRKCA,RXRG,PIK3R3,STK4,PIK3CA,SOS2,BAD
hsa05223	Non-small cell lung cancer	0.162001539459035	-1.82014944096135	58	24	0.0097442143727162	2463	7161	6789,572,6655,5290,8503,5578,6258,10000,6776,5579,1019,5604,208,5894,595,5925,2272,3265,5296,7157,207,5295,1021,3845	STK4,BAD,SOS2,PIK3CA,PIK3R3,PRKCA,RXRG,AKT3,STAT5A,PRKCB,CDK4,MAP2K1,AKT2,RAF1,CCND1,RB1,FHIT,HRAS,PIK3R2,TP53,AKT1,PIK3R1,CDK6,KRAS
hsa04012	ErbB signaling pathway	0.163489097834436	-1.81100897077974	85	34	0.0138043036946813	2463	7161	5295,53358,3845,5296,1839,207,5062,6464,3265,2549,6714,1399,4690,5602,5894,57144,867,5604,208,56924,2002,3725,10000,1026,6776,5579,4609,8503,5578,818,6655,572,1027,5290	PIK3R1,SHC3,KRAS,PIK3R2,HBEGF,AKT1,PAK2,SHC1,HRAS,GAB1,SRC,CRKL,NCK1,MAPK10,RAF1,PAK5,CBL,MAP2K1,AKT2,PAK6,ELK1,JUN,AKT3,CDKN1A,STAT5A,PRKCB,MYC,PIK3R3,PRKCA,CAMK2G,SOS2,BAD,CDKN1B,PIK3CA
ko04012	ErbB signaling pathway	0.163489097834436	-1.81100897077974	85	34	0.0138043036946813	2463	7161	5295,53358,3845,5296,1839,207,5062,6464,2549,6714,3265,1399,5602,4690,5894,57144,867,5604,208,56924,3725,2002,10000,1026,5579,6776,4609,8503,5578,818,572,6655,1027,5290	PIK3R1,SHC3,KRAS,PIK3R2,HBEGF,AKT1,PAK2,SHC1,GAB1,SRC,HRAS,CRKL,MAPK10,NCK1,RAF1,PAK5,CBL,MAP2K1,AKT2,PAK6,JUN,ELK1,AKT3,CDKN1A,PRKCB,STAT5A,MYC,PIK3R3,PRKCA,CAMK2G,BAD,SOS2,CDKN1B,PIK3CA
M00353	Spliceosome, Prp19/CDC5L complex	0.170518518827779	-1.76891137333105	14	7	0.00284206252537556	2463	7161	51503,51729,10084,27339,988,56259,3312	CWC15,WBP11,PQBP1,PRPF19,CDC5L,CTNNBL1,HSPA8
hsa_M00353	Spliceosome, Prp19/CDC5L complex	0.170518518827779	-1.76891137333105	14	7	0.00284206252537556	2463	7161	56259,27339,51503,51729,988,3312,10084	CTNNBL1,PRPF19,CWC15,WBP11,CDC5L,HSPA8,PQBP1
M00147	NADH dehydrogenase (ubiquinone) 1 beta subcomplex	0.170518518827779	-1.76891137333105	14	7	0.00284206252537556	2463	7161	4716,4711,4713,4712,4714,4710,4718	NDUFB10,NDUFB5,NDUFB7,NDUFB6,NDUFB8,NDUFB4,NDUFC2
M00180	RNA polymerase II, eukaryotes	0.170518518827779	-1.76891137333105	14	7	0.00284206252537556	2463	7161	5435,5432,5433,5431,5441,5436,5438	POLR2F,POLR2C,POLR2D,POLR2B,POLR2L,POLR2G,POLR2I
hsa_M00147	NADH dehydrogenase (ubiquinone) 1 beta subcomplex	0.170518518827779	-1.76891137333105	14	7	0.00284206252537556	2463	7161	4710,4718,4714,4711,4713,4712,4716	NDUFB4,NDUFC2,NDUFB8,NDUFB5,NDUFB7,NDUFB6,NDUFB10
hsa_M00180	RNA polymerase II, eukaryotes	0.170518518827779	-1.76891137333105	14	7	0.00284206252537556	2463	7161	5436,5438,5435,5431,5432,5433,5441	POLR2G,POLR2I,POLR2F,POLR2B,POLR2C,POLR2D,POLR2L
hsa04144	Endocytosis	0.173213409601268	-1.75323086321067	260	97	0.0393828664230613	2463	7161	11031,857,84249,153,8394,9559,998,1175,3559,5878,8724,50855,27128,9815,3312,155,3560,9525,51534,10193,51160,1234,3815,5119,5867,11021,3480,56904,57154,30844,51324,57403,4233,9922,382,9266,829,390243,4087,3949,116986,9146,55738,25978,10109,4193,51100,859,9267,92421,3577,10617,4088,7043,830,7037,6642,2350,858,154,112936,1785,2348,7251,9230,27131,867,26286,5371,160,8766,10094,6714,3265,9101,5868,64744,1173,30845,27243,7042,57132,6643,11059,8976,29934,116987,27183,23527,3561,7048,7852,10938,7189,10565,51510,375	RAB31,CAV1,PSD2,ADRB1,PIP5K1A,VPS26A,CDC42,AP2S1,IL2RA,RAB5C,SNX3,PARD6A,CYTH4,GIT2,HSPA8,ADRB3,IL2RB,VPS4B,VTA1,RNF41,VPS28,CCR5,KIT,CHMP1A,RAB4A,RAB35,IGF1R,SH3GLB2,SMURF1,EHD4,SPG21,RAB22A,MET,IQSEC1,ARF6,CYTH2,CAPZA1,IZUMO1R,SMAD2,LDLR,AGAP2,HGS,ARFGAP1,CHMP2B,ARPC2,MDM2,SH3GLB1,CAV3,CYTH1,CHMP4C,CXCR1,STAMBP,SMAD3,TGFB3,CAPZA2,TFRC,SNX1,FOLR2,CAV2,ADRB2,VPS26B,DNM2,FOLR1,TSG101,RAB11B,SNX5,CBL,ARFGAP3,PML,AP2A1,RAB11A,ARPC3,SRC,HRAS,USP8,RAB5A,SMAP2,AP2M1,EHD3,CHMP2A,TGFB2,CHMP1B,SNX2,WWP1,WASL,SNX12,AGAP1,VPS4A,ACAP2,IL2RG,TGFBR2,CXCR4,EHD1,TRAF6,ARFGEF1,CHMP5,ARF1
ko04144	Endocytosis	0.173213409601268	-1.75323086321067	260	97	0.0393828664230613	2463	7161	55738,9146,116986,25978,10109,4087,3949,57403,9922,4233,390243,829,382,9266,57154,3480,11021,56904,51324,30844,51160,10193,5867,3815,1234,5119,3312,9815,50855,27128,51534,3560,155,9525,5878,3559,998,1175,8724,84249,857,11031,8394,153,9559,7048,7852,3561,10938,27183,116987,23527,7189,51510,10565,375,8976,11059,6643,29934,27243,1173,64744,30845,57132,7042,5371,160,3265,6714,9101,5868,8766,10094,7251,1785,2348,26286,867,9230,27131,2350,7037,6642,154,858,112936,4088,10617,3577,830,7043,859,51100,4193,9267,92421	ARFGAP1,HGS,AGAP2,CHMP2B,ARPC2,SMAD2,LDLR,RAB22A,IQSEC1,MET,IZUMO1R,CAPZA1,ARF6,CYTH2,SMURF1,IGF1R,RAB35,SH3GLB2,SPG21,EHD4,VPS28,RNF41,RAB4A,KIT,CCR5,CHMP1A,HSPA8,GIT2,PARD6A,CYTH4,VTA1,IL2RB,ADRB3,VPS4B,RAB5C,IL2RA,CDC42,AP2S1,SNX3,PSD2,CAV1,RAB31,PIP5K1A,ADRB1,VPS26A,TGFBR2,CXCR4,IL2RG,EHD1,VPS4A,AGAP1,ACAP2,TRAF6,CHMP5,ARFGEF1,ARF1,WASL,WWP1,SNX2,SNX12,CHMP2A,AP2M1,SMAP2,EHD3,CHMP1B,TGFB2,PML,AP2A1,HRAS,SRC,USP8,RAB5A,RAB11A,ARPC3,TSG101,DNM2,FOLR1,ARFGAP3,CBL,RAB11B,SNX5,FOLR2,TFRC,SNX1,ADRB2,CAV2,VPS26B,SMAD3,STAMBP,CXCR1,CAPZA2,TGFB3,CAV3,SH3GLB1,MDM2,CYTH1,CHMP4C
ko03015	mRNA surveillance pathway	0.175020393901635	-1.74285277526771	91	36	0.0146163215590743	2463	7161	5518,10914,84305,7919,53981,55916,10189,23283,10978,10898,22916,29101,53918,2107,29894,29107,23381,5525,5523,5522,22794,1479,5500,4116,26986,5516,56903,80336,5529,65109,10284,140886,80335,9775,5501,55110	PPP2R1A,PAPOLA,PYM1,DDX39B,CPSF2,NXT2,ALYREF,CSTF2T,CLP1,CPSF4,NCBP2,SSU72,PELO,ETF1,CPSF1,NXT1,SMG5,PPP2R5A,PPP2R3A,PPP2R2C,CASC3,CSTF3,PPP1CB,MAGOH,PABPC1,PPP2CB,PAPOLB,PABPC1L,PPP2R5E,UPF3B,SAP18,PABPC5,WDR82,EIF4A3,PPP1CC,MAGOHB
hsa03015	mRNA surveillance pathway	0.175020393901635	-1.74285277526771	91	36	0.0146163215590743	2463	7161	1479,22794,5523,5522,23381,5525,29107,53918,29894,2107,29101,22916,23283,10898,10978,10189,55916,7919,53981,10914,84305,5518,5501,55110,9775,140886,10284,80335,5529,65109,80336,56903,5516,4116,26986,5500	CSTF3,CASC3,PPP2R3A,PPP2R2C,SMG5,PPP2R5A,NXT1,PELO,CPSF1,ETF1,SSU72,NCBP2,CSTF2T,CPSF4,CLP1,ALYREF,NXT2,DDX39B,CPSF2,PAPOLA,PYM1,PPP2R1A,PPP1CC,MAGOHB,EIF4A3,PABPC5,SAP18,WDR82,PPP2R5E,UPF3B,PABPC1L,PAPOLB,PPP2CB,MAGOH,PABPC1,PPP1CB
ko05145	Toxoplasmosis	0.177087708379457	-1.731110141574	113	44	0.0178643930166464	2463	7161	4790,4615,10000,7189,3913,5294,958,3949,3586,10105,10454,3458,3655,7042,2775,959,3716,3592,4792,6772,208,1234,2771,572,7124,3312,7097,23118,5608,207,51135,3717,2773,7043,23643,7099,3551,329,5602,598,3593,3459,5606,4793	NFKB1,MYD88,AKT3,TRAF6,LAMB2,PIK3CG,CD40,LDLR,IL10,PPIF,TAB1,IFNG,ITGA6,TGFB2,GNAO1,CD40LG,JAK1,IL12A,NFKBIA,STAT1,AKT2,CCR5,GNAI2,BAD,TNF,HSPA8,TLR2,TAB2,MAP2K6,AKT1,IRAK4,JAK2,GNAI3,TGFB3,LY96,TLR4,IKBKB,BIRC2,MAPK10,BCL2L1,IL12B,IFNGR1,MAP2K3,NFKBIB
hsa05145	Toxoplasmosis	0.177087708379457	-1.731110141574	113	44	0.0178643930166464	2463	7161	7099,3551,329,5602,598,3593,3459,5606,4793,207,51135,3717,2773,7043,23643,572,7124,3312,7097,5608,23118,6772,208,1234,2771,959,3716,3592,4792,3458,3655,7042,2775,5294,958,3949,3586,10105,10454,4790,4615,10000,7189,3913	TLR4,IKBKB,BIRC2,MAPK10,BCL2L1,IL12B,IFNGR1,MAP2K3,NFKBIB,AKT1,IRAK4,JAK2,GNAI3,TGFB3,LY96,BAD,TNF,HSPA8,TLR2,MAP2K6,TAB2,STAT1,AKT2,CCR5,GNAI2,CD40LG,JAK1,IL12A,NFKBIA,IFNG,ITGA6,TGFB2,GNAO1,PIK3CG,CD40,LDLR,IL10,PPIF,TAB1,NFKB1,MYD88,AKT3,TRAF6,LAMB2
hsa04371	Apelin signaling pathway	0.180694261616594	-1.71094883829886	138	53	0.0215184734064149	2463	7161	2790,5564,4087,5294,4205,22808,22800,1958,55970,2782,10000,2785,11345,108,187,5604,5894,5567,4208,51764,4089,100271849,3265,2776,51806,109,59345,2788,10014,56848,5571,23710,2787,8862,59,11337,2791,54331,2771,208,8678,6696,595,23236,5581,2784,4088,6546,5330,207,2793,2773,3845	GNG10,PRKAB1,SMAD2,PIK3CG,MEF2A,MRAS,RRAS2,EGR1,GNG12,GNB1,AKT3,GNG3,GABARAPL2,ADCY2,APLNR,MAP2K1,RAF1,PRKACB,MEF2C,GNG13,SMAD4,MEF2B,HRAS,GNAQ,CALML5,ADCY3,GNB4,GNG7,HDAC5,SPHK2,PRKAG1,GABARAPL1,GNG5,APLN,ACTA2,GABARAP,GNG11,GNG2,GNAI2,AKT2,BECN1,SPP1,CCND1,PLCB1,PRKCE,GNB3,SMAD3,SLC8A1,PLCB2,AKT1,GNGT2,GNAI3,KRAS
hsa04022	cGMP-PKG signaling pathway	0.181857834378487	-1.70453002693471	163	62	0.0251725537961835	2463	7161	3778,10105,7417,140,3764,5138,5997,4205,5294,1909,5604,108,9569,5530,10000,478,83447,134,9475,4208,100271849,5535,292,468,5894,2983,1385,477,5501,2767,51806,2776,109,155,154,483,481,572,493,6093,4659,2771,7416,208,3779,10488,148,291,5350,153,5581,23236,5500,148327,2969,476,2773,10242,4882,207,5330,6546	KCNMA1,PPIF,VDAC2,ADORA3,KCNJ8,PDE2A,RGS2,MEF2A,PIK3CG,EDNRA,MAP2K1,ADCY2,GTF2IRD1,PPP3CA,AKT3,ATP1A3,SLC25A31,ADORA1,ROCK2,MEF2C,MEF2B,PPP3R2,SLC25A5,ATF4,RAF1,GUCY1B1,CREB1,ATP1A2,PPP1CC,GNA11,CALML5,GNAQ,ADCY3,ADRB3,ADRB2,ATP1B3,ATP1B1,BAD,ATP2B4,ROCK1,PPP1R12A,GNAI2,VDAC1,AKT2,KCNMB1,CREB3,ADRA1A,SLC25A4,PLN,ADRB1,PRKCE,PLCB1,PPP1CB,CREB3L4,GTF2I,ATP1A1,GNAI3,KCNMB2,NPR2,AKT1,PLCB2,SLC8A1
ko04022	cGMP-PKG signaling pathway	0.181857834378487	-1.70453002693471	163	62	0.0251725537961835	2463	7161	153,5581,23236,5500,148327,2969,476,2773,10242,4882,207,5330,6546,155,154,483,481,572,493,6093,4659,2771,7416,208,3779,10488,148,5350,291,83447,134,9475,4208,100271849,5535,292,468,5894,2983,1385,477,5501,2767,51806,2776,109,3778,10105,7417,140,3764,5997,5138,5294,4205,1909,5604,108,9569,5530,10000,478	ADRB1,PRKCE,PLCB1,PPP1CB,CREB3L4,GTF2I,ATP1A1,GNAI3,KCNMB2,NPR2,AKT1,PLCB2,SLC8A1,ADRB3,ADRB2,ATP1B3,ATP1B1,BAD,ATP2B4,ROCK1,PPP1R12A,GNAI2,VDAC1,AKT2,KCNMB1,CREB3,ADRA1A,PLN,SLC25A4,SLC25A31,ADORA1,ROCK2,MEF2C,MEF2B,PPP3R2,SLC25A5,ATF4,RAF1,GUCY1B1,CREB1,ATP1A2,PPP1CC,GNA11,CALML5,GNAQ,ADCY3,KCNMA1,PPIF,VDAC2,ADORA3,KCNJ8,RGS2,PDE2A,PIK3CG,MEF2A,EDNRA,MAP2K1,ADCY2,GTF2IRD1,PPP3CA,AKT3,ATP1A3
ko04370	VEGF signaling pathway	0.187894986486049	-1.67187205473854	59	24	0.0097442143727162	2463	7161	8503,5578,5880,572,3315,5290,5604,208,5530,10000,5579,100137049,6714,3265,5535,7422,5894,5295,56848,7867,3845,998,5296,207	PIK3R3,PRKCA,RAC2,BAD,HSPB1,PIK3CA,MAP2K1,AKT2,PPP3CA,AKT3,PRKCB,PLA2G4B,SRC,HRAS,PPP3R2,VEGFA,RAF1,PIK3R1,SPHK2,MAPKAPK3,KRAS,CDC42,PIK3R2,AKT1
hsa04370	VEGF signaling pathway	0.187894986486049	-1.67187205473854	59	24	0.0097442143727162	2463	7161	5894,7422,5535,3265,6714,100137049,207,998,5296,56848,3845,7867,5295,5290,3315,572,5880,5578,8503,5579,10000,5530,208,5604	RAF1,VEGFA,PPP3R2,HRAS,SRC,PLA2G4B,AKT1,CDC42,PIK3R2,SPHK2,KRAS,MAPKAPK3,PIK3R1,PIK3CA,HSPB1,BAD,RAC2,PRKCA,PIK3R3,PRKCB,AKT3,PPP3CA,AKT2,MAP2K1
hsa05224	Breast cancer	0.188606584781866	-1.66809199538449	144	55	0.022330491270808	2463	7161	2100,8822,5296,207,5295,3845,5728,27006,4040,595,2258,6464,6667,2248,8322,1026,7476,1019,3815,7472,3725,8074,208,3479,5290,2252,6655,2255,1452,2246,7480,8503,5241,672,8823,7157,4853,7976,2353,1021,53358,3480,5925,5894,3265,8323,1856,10000,4609,2257,5604,1499,23493,122011,2260	ESR2,FGF17,PIK3R2,AKT1,PIK3R1,KRAS,PTEN,FGF22,LRP6,CCND1,FGF13,SHC1,SP1,FGF3,FZD4,CDKN1A,WNT7A,CDK4,KIT,WNT2,JUN,FGF23,AKT2,IGF1,PIK3CA,FGF7,SOS2,FGF10,CSNK1A1,FGF1,WNT10B,PIK3R3,PGR,BRCA1,FGF16,TP53,NOTCH2,FZD3,FOS,CDK6,SHC3,IGF1R,RB1,RAF1,HRAS,FZD6,DVL2,AKT3,MYC,FGF12,MAP2K1,CTNNB1,HEY2,CSNK1A1L,FGFR1
ko05224	Breast cancer	0.188606584781866	-1.66809199538449	144	55	0.022330491270808	2463	7161	10000,4609,2257,1499,5604,23493,122011,2260,5241,7157,8823,672,4853,7976,2353,1021,53358,3480,5925,5894,1856,8323,3265,7476,1026,1019,7472,3815,208,8074,3725,3479,2252,5290,6655,2255,1452,2246,7480,8503,2100,5296,8822,207,5295,27006,3845,5728,595,4040,6464,2258,2248,6667,8322	AKT3,MYC,FGF12,CTNNB1,MAP2K1,HEY2,CSNK1A1L,FGFR1,PGR,TP53,FGF16,BRCA1,NOTCH2,FZD3,FOS,CDK6,SHC3,IGF1R,RB1,RAF1,DVL2,FZD6,HRAS,WNT7A,CDKN1A,CDK4,WNT2,KIT,AKT2,FGF23,JUN,IGF1,FGF7,PIK3CA,SOS2,FGF10,CSNK1A1,FGF1,WNT10B,PIK3R3,ESR2,PIK3R2,FGF17,AKT1,PIK3R1,FGF22,KRAS,PTEN,CCND1,LRP6,SHC1,FGF13,FGF3,SP1,FZD4
hsa_M00072	N-glycosylation by oligosaccharyltransferase	0.189881939659234	-1.66135277016669	7	4	0.00162403572878603	2463	7161	7991,6184,3703,1603	TUSC3,RPN1,STT3A,DAD1
M00072	N-glycosylation by oligosaccharyltransferase	0.189881939659234	-1.66135277016669	7	4	0.00162403572878603	2463	7161	7991,1603,3703,6184	TUSC3,DAD1,STT3A,RPN1
ko04724	Glutamatergic synapse	0.196181242329566	-1.62871634126552	114	44	0.0178643930166464	2463	7161	2784,2918,23236,6507,5330,2890,9454,10991,2773,2793,54407,3760,2912,2787,5579,1742,7220,2771,54331,2791,5567,6506,2911,5535,100137049,51764,6505,2891,59345,109,2776,2788,2775,2790,55970,9456,5578,81539,2752,2897,2785,5530,2782,108	GNB3,GRM8,PLCB1,SLC1A3,PLCB2,GRIA1,HOMER3,SLC38A3,GNAI3,GNGT2,SLC38A2,KCNJ3,GRM2,GNG5,PRKCB,DLG4,TRPC1,GNAI2,GNG2,GNG11,PRKACB,SLC1A2,GRM1,PPP3R2,PLA2G4B,GNG13,SLC1A1,GRIA2,GNB4,ADCY3,GNAQ,GNG7,GNAO1,GNG10,GNG12,HOMER1,PRKCA,SLC38A1,GLUL,GRIK1,GNG3,PPP3CA,GNB1,ADCY2
hsa04724	Glutamatergic synapse	0.196181242329566	-1.62871634126552	114	44	0.0178643930166464	2463	7161	7220,2791,54331,2771,5579,1742,2787,54407,2912,3760,2793,10991,2773,9454,2890,5330,6507,2918,2784,23236,108,2897,2752,81539,2782,5530,2785,5578,9456,55970,2790,2788,2775,59345,109,2776,5535,2891,6505,51764,100137049,5567,6506,2911	TRPC1,GNG11,GNG2,GNAI2,PRKCB,DLG4,GNG5,SLC38A2,GRM2,KCNJ3,GNGT2,SLC38A3,GNAI3,HOMER3,GRIA1,PLCB2,SLC1A3,GRM8,GNB3,PLCB1,ADCY2,GRIK1,GLUL,SLC38A1,GNB1,PPP3CA,GNG3,PRKCA,HOMER1,GNG12,GNG10,GNG7,GNAO1,GNB4,ADCY3,GNAQ,PPP3R2,GRIA2,SLC1A1,GNG13,PLA2G4B,PRKACB,SLC1A2,GRM1
hsa04914	Progesterone-mediated oocyte maturation	0.196279918739363	-1.62821348176417	92	36	0.0146163215590743	2463	7161	207,109,5296,5241,3845,5295,246184,2773,3326,5567,388333,5894,890,3480,5602,29945,891,983,29882,8697,10000,5604,108,208,2771,4085,64506,51343,51529,5290,10459,8881,3479,3320,8503,25847	AKT1,ADCY3,PIK3R2,PGR,KRAS,PIK3R1,CDC26,GNAI3,HSP90AB1,PRKACB,SPDYE4,RAF1,CCNA2,IGF1R,MAPK10,ANAPC4,CCNB1,CDK1,ANAPC2,CDC23,AKT3,MAP2K1,ADCY2,AKT2,GNAI2,MAD2L1,CPEB1,FZR1,ANAPC11,PIK3CA,MAD2L2,CDC16,IGF1,HSP90AA1,PIK3R3,ANAPC13
ko04914	Progesterone-mediated oocyte maturation	0.196279918739363	-1.62821348176417	92	36	0.0146163215590743	2463	7161	207,109,5296,5241,3845,2773,246184,5295,3326,5894,388333,5567,890,3480,5602,29945,891,983,8697,10000,29882,5604,208,108,2771,4085,51343,64506,51529,5290,3479,8881,10459,8503,3320,25847	AKT1,ADCY3,PIK3R2,PGR,KRAS,GNAI3,CDC26,PIK3R1,HSP90AB1,RAF1,SPDYE4,PRKACB,CCNA2,IGF1R,MAPK10,ANAPC4,CCNB1,CDK1,CDC23,AKT3,ANAPC2,MAP2K1,AKT2,ADCY2,GNAI2,MAD2L1,FZR1,CPEB1,ANAPC11,PIK3CA,IGF1,CDC16,MAD2L2,PIK3R3,HSP90AA1,ANAPC13
M00003	Gluconeogenesis, oxaloacetate => fructose-6P	0.197108573875376	-1.62400056564082	17	8	0.00324807145757207	2463	7161	2026,5223,8789,2203,5106,5230,2023,2597	ENO2,PGAM1,FBP2,FBP1,PCK2,PGK1,ENO1,GAPDH
ko00450	Selenocompound metabolism	0.197108573875376	-1.62400056564082	17	8	0.00324807145757207	2463	7161	4141,10587,11185,22928,7296,22929,114112,9060	MARS1,TXNRD2,INMT,SEPHS2,TXNRD1,SEPHS1,TXNRD3,PAPSS2
hsa00450	Selenocompound metabolism	0.197108573875376	-1.62400056564082	17	8	0.00324807145757207	2463	7161	114112,9060,7296,22929,22928,4141,10587,11185	TXNRD3,PAPSS2,TXNRD1,SEPHS1,SEPHS2,MARS1,TXNRD2,INMT
hsa_M00003	Gluconeogenesis, oxaloacetate => fructose-6P	0.197108573875376	-1.62400056564082	17	8	0.00324807145757207	2463	7161	5106,8789,2203,5223,2026,2597,2023,5230	PCK2,FBP2,FBP1,PGAM1,ENO2,GAPDH,ENO1,PGK1
hsa04923	Regulation of lipolysis in adipocytes	0.198833873853693	-1.61528560765649	54	22	0.00893219650832318	2463	7161	2167,4852,109,7253,207,10000,5296,108,208,11145,5295,2771,4886,2773,5290,5567,51099,8503,154,134,153,155	FABP4,NPY,ADCY3,TSHR,AKT1,AKT3,PIK3R2,ADCY2,AKT2,PLAAT3,PIK3R1,GNAI2,NPY1R,GNAI3,PIK3CA,PRKACB,ABHD5,PIK3R3,ADRB2,ADORA1,ADRB1,ADRB3
hsa_M00412	ESCRT-III complex	0.19946607734251	-1.61211109549379	12	6	0.00243605359317905	2463	7161	51510,57132,92421,27243,5119,25978	CHMP5,CHMP1B,CHMP4C,CHMP2A,CHMP1A,CHMP2B
M00412	ESCRT-III complex	0.19946607734251	-1.61211109549379	12	6	0.00243605359317905	2463	7161	92421,57132,51510,27243,5119,25978	CHMP4C,CHMP1B,CHMP5,CHMP2A,CHMP1A,CHMP2B
ko00510	N-Glycan biosynthesis	0.21069916924459	-1.55732390101512	49	20	0.00812017864393017	2463	7161	23193,10905,22845,8703,2683,146664,2530,6184,85365,11320,8818,1798,4245,1603,11282,7991,6480,440138,3703,29880	GANAB,MAN1A2,DOLK,B4GALT3,B4GALT1,MGAT5B,FUT8,RPN1,ALG2,MGAT4A,DPM2,DPAGT1,MGAT1,DAD1,MGAT4B,TUSC3,ST6GAL1,ALG11,STT3A,ALG5
hsa00510	N-Glycan biosynthesis	0.21069916924459	-1.55732390101512	49	20	0.00812017864393017	2463	7161	8703,2683,22845,23193,10905,6184,146664,2530,11320,85365,8818,1798,1603,4245,7991,11282,29880,3703,440138,6480	B4GALT3,B4GALT1,DOLK,GANAB,MAN1A2,RPN1,MGAT5B,FUT8,MGAT4A,ALG2,DPM2,DPAGT1,DAD1,MGAT1,TUSC3,MGAT4B,ALG5,STT3A,ALG11,ST6GAL1
ko01521	EGFR tyrosine kinase inhibitor resistance	0.212729467078874	-1.54773402815392	79	31	0.0125862768980918	2463	7161	5290,572,6655,3479,581,3569,5578,8503,5579,9470,10000,1977,208,5604,5894,598,7422,3480,3716,2549,6714,3265,6464,3717,4233,207,5296,53358,5728,3845,5295	PIK3CA,BAD,SOS2,IGF1,BAX,IL6,PRKCA,PIK3R3,PRKCB,EIF4E2,AKT3,EIF4E,AKT2,MAP2K1,RAF1,BCL2L1,VEGFA,IGF1R,JAK1,GAB1,SRC,HRAS,SHC1,JAK2,MET,AKT1,PIK3R2,SHC3,PTEN,KRAS,PIK3R1
hsa01521	EGFR tyrosine kinase inhibitor resistance	0.212729467078874	-1.54773402815392	79	31	0.0125862768980918	2463	7161	5578,8503,5290,572,6655,581,3479,3569,208,5604,5579,9470,10000,1977,6714,3265,2549,6464,5894,598,3480,3716,7422,3845,5728,53358,5295,3717,4233,207,5296	PRKCA,PIK3R3,PIK3CA,BAD,SOS2,BAX,IGF1,IL6,AKT2,MAP2K1,PRKCB,EIF4E2,AKT3,EIF4E,SRC,HRAS,GAB1,SHC1,RAF1,BCL2L1,IGF1R,JAK1,VEGFA,KRAS,PTEN,SHC3,PIK3R1,JAK2,MET,AKT1,PIK3R2
hsa04010	MAPK signaling pathway	0.217622206580875	-1.52499471690551	255	94	0.0381648396264718	2463	7161	5908,5578,22800,22808,785,3552,10235,7189,2005,4616,7048,355,4609,5530,1649,3265,5535,5906,5567,1852,783,1845,7042,5495,1647,7157,5608,7124,3315,6655,2252,3553,8074,6788,4909,10368,5606,2258,3551,356,5602,1399,27006,4149,7043,207,55970,2260,1848,10454,784,6789,5604,2002,2257,10912,4790,10000,8649,8986,7850,4208,100137049,5062,5894,5536,9020,11221,84867,468,7867,2353,8823,23118,5880,2246,2255,3312,3725,208,5579,4915,25780,2248,7786,8550,1843,7186,3845,929,4215,998,4296,8822	RAP1B,PRKCA,RRAS2,MRAS,CACNB4,IL1A,RASGRP2,TRAF6,ELK4,GADD45B,TGFBR2,FAS,MYC,PPP3CA,DDIT3,HRAS,PPP3R2,RAP1A,PRKACB,DUSP9,CACNB2,DUSP3,TGFB2,PPM1B,GADD45A,TP53,MAP2K6,TNF,HSPB1,SOS2,FGF7,IL1B,FGF23,STK3,NTF4,CACNG3,MAP2K3,FGF13,IKBKB,FASLG,MAPK10,CRKL,FGF22,MAX,TGFB3,AKT1,GNG12,FGFR1,DUSP6,TAB1,CACNB3,STK4,MAP2K1,ELK1,FGF12,GADD45G,NFKB1,AKT3,LAMTOR3,RPS6KA4,IL1R2,MEF2C,PLA2G4B,PAK2,RAF1,PPP5C,MAP3K14,DUSP10,PTPN5,ATF4,MAPKAPK3,FOS,FGF16,TAB2,RAC2,FGF1,FGF10,HSPA8,JUN,AKT2,PRKCB,NTRK2,RASGRP3,FGF3,MAP3K12,MAPKAPK5,DUSP1,TRAF2,KRAS,CD14,MAP3K3,CDC42,MAP3K11,FGF17
ko04010	MAPK signaling pathway	0.217622206580875	-1.52499471690551	255	94	0.0381648396264718	2463	7161	7850,100137049,4208,5062,8986,84867,468,5894,5536,11221,9020,2353,7867,8823,10454,55970,1848,2260,6789,784,2257,10912,5604,2002,10000,8649,4790,7786,2248,25780,8550,1843,7186,3845,929,998,4296,8822,4215,2246,23118,5880,2255,3312,3725,208,4915,5579,5906,3265,5535,1845,783,5567,1852,7042,5495,1647,7157,22808,5578,5908,22800,785,3552,10235,4616,2005,7189,5530,1649,7048,355,4609,5606,2258,3551,356,5602,1399,7043,27006,4149,207,5608,3553,6655,3315,7124,2252,6788,8074,10368,4909	IL1R2,PLA2G4B,MEF2C,PAK2,RPS6KA4,PTPN5,ATF4,RAF1,PPP5C,DUSP10,MAP3K14,FOS,MAPKAPK3,FGF16,TAB1,GNG12,DUSP6,FGFR1,STK4,CACNB3,FGF12,GADD45G,MAP2K1,ELK1,AKT3,LAMTOR3,NFKB1,MAP3K12,FGF3,RASGRP3,MAPKAPK5,DUSP1,TRAF2,KRAS,CD14,CDC42,MAP3K11,FGF17,MAP3K3,FGF1,TAB2,RAC2,FGF10,HSPA8,JUN,AKT2,NTRK2,PRKCB,RAP1A,HRAS,PPP3R2,DUSP3,CACNB2,PRKACB,DUSP9,TGFB2,PPM1B,GADD45A,TP53,MRAS,PRKCA,RAP1B,RRAS2,CACNB4,IL1A,RASGRP2,GADD45B,ELK4,TRAF6,PPP3CA,DDIT3,TGFBR2,FAS,MYC,MAP2K3,FGF13,IKBKB,FASLG,MAPK10,CRKL,TGFB3,FGF22,MAX,AKT1,MAP2K6,IL1B,SOS2,HSPB1,TNF,FGF7,STK3,FGF23,CACNG3,NTF4
hsa04657	IL-17 signaling pathway	0.218812641836366	-1.51953943205785	93	36	0.0146163215590743	2463	7161	3567,5596,4792,3551,5602,7186,3576,3596,4318,1437,6279,2353,3326,6426,3627,3458,2919,3565,112744,6361,3320,23118,3569,3553,7124,6347,7189,3725,29110,6356,6364,2921,4790,7184,10758,7128	IL5,MAPK4,NFKBIA,IKBKB,MAPK10,TRAF2,CXCL8,IL13,MMP9,CSF2,S100A8,FOS,HSP90AB1,SRSF1,CXCL10,IFNG,CXCL1,IL4,IL17F,CCL17,HSP90AA1,TAB2,IL6,IL1B,TNF,CCL2,TRAF6,JUN,TBK1,CCL11,CCL20,CXCL3,NFKB1,HSP90B1,TRAF3IP2,TNFAIP3
ko04657	IL-17 signaling pathway	0.218812641836366	-1.51953943205785	93	36	0.0146163215590743	2463	7161	112744,6361,3320,23118,3569,3553,7124,6347,7189,3725,29110,6356,2921,6364,4790,10758,7128,7184,3567,5596,4792,3551,5602,7186,3576,3596,4318,1437,6279,2353,3326,6426,3627,3458,2919,3565	IL17F,CCL17,HSP90AA1,TAB2,IL6,IL1B,TNF,CCL2,TRAF6,JUN,TBK1,CCL11,CXCL3,CCL20,NFKB1,TRAF3IP2,TNFAIP3,HSP90B1,IL5,MAPK4,NFKBIA,IKBKB,MAPK10,TRAF2,CXCL8,IL13,MMP9,CSF2,S100A8,FOS,HSP90AB1,SRSF1,CXCL10,IFNG,CXCL1,IL4
ko00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.21962576799098	-1.5158302356524	20	9	0.00365408038976857	2463	7161	55790,166012,50515,11285,54480,79586,10090,55454,56548	CSGALNACT1,CHST13,CHST11,B4GALT7,CHPF2,CHPF,UST,CSGALNACT2,CHST7
hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	0.21962576799098	-1.5158302356524	20	9	0.00365408038976857	2463	7161	166012,55790,50515,55454,79586,10090,56548,11285,54480	CHST13,CSGALNACT1,CHST11,CSGALNACT2,CHPF,UST,CHST7,B4GALT7,CHPF2
hsa04931	Insulin resistance	0.222895886914821	-1.50105049136343	107	41	0.0166463662200568	2463	7161	5588,3551,5500,9882,148327,5602,5781,5465,7376,5581,5834,4792,207,5296,200186,5728,5501,1385,5295,9021,7124,5290,5564,5507,3569,5571,8503,2673,5837,5106,5770,948,4790,5579,1375,10488,2997,92579,10000,208,6513	PRKCQ,IKBKB,PPP1CB,TBC1D4,CREB3L4,MAPK10,PTPN11,PPARA,NR1H2,PRKCE,PYGB,NFKBIA,AKT1,PIK3R2,CRTC2,PTEN,PPP1CC,CREB1,PIK3R1,SOCS3,TNF,PIK3CA,PRKAB1,PPP1R3C,IL6,PRKAG1,PIK3R3,GFPT1,PYGM,PCK2,PTPN1,CD36,NFKB1,PRKCB,CPT1B,CREB3,GYS1,G6PC3,AKT3,AKT2,SLC2A1
hsa04973	Carbohydrate digestion and absorption	0.223633939658774	-1.49774476183702	44	18	0.00730816077953715	2463	7161	80834,8503,481,483,280,5290,476,2542,5295,477,208,5296,92579,10000,207,5330,5579,478	TAS1R2,PIK3R3,ATP1B1,ATP1B3,AMY2B,PIK3CA,ATP1A1,SLC37A4,PIK3R1,ATP1A2,AKT2,PIK3R2,G6PC3,AKT3,AKT1,PLCB2,PRKCB,ATP1A3
ko04962	Vasopressin-regulated water reabsorption	0.223633939658774	-1.49774476183702	44	18	0.00730816077953715	2463	7161	1781,10488,5878,109,6844,9230,359,360,1385,8655,148327,51164,5567,8766,10671,361,1780,5868	DYNC1I2,CREB3,RAB5C,ADCY3,VAMP2,RAB11B,AQP2,AQP3,CREB1,DYNLL1,CREB3L4,DCTN4,PRKACB,RAB11A,DCTN6,AQP4,DYNC1I1,RAB5A
hsa04962	Vasopressin-regulated water reabsorption	0.223633939658774	-1.49774476183702	44	18	0.00730816077953715	2463	7161	8655,148327,51164,5567,10671,8766,361,1780,5868,1781,10488,5878,109,6844,9230,359,360,1385	DYNLL1,CREB3L4,DCTN4,PRKACB,DCTN6,RAB11A,AQP4,DYNC1I1,RAB5A,DYNC1I2,CREB3,RAB5C,ADCY3,VAMP2,RAB11B,AQP2,AQP3,CREB1
ko04973	Carbohydrate digestion and absorption	0.223633939658774	-1.49774476183702	44	18	0.00730816077953715	2463	7161	5295,2542,477,208,5296,10000,92579,207,5330,5579,478,80834,8503,280,481,483,5290,476	PIK3R1,SLC37A4,ATP1A2,AKT2,PIK3R2,AKT3,G6PC3,AKT1,PLCB2,PRKCB,ATP1A3,TAS1R2,PIK3R3,AMY2B,ATP1B1,ATP1B3,PIK3CA,ATP1A1
ko04260	Cardiac muscle contraction	0.225121029888806	-1.49111711078286	74	29	0.0117742590336987	2463	7161	481,483,1340,785,170712,784,1349,9377,7385,10368,478,1351,1537,783,7388,27089,476,10975,1339,7384,125965,1327,6546,1346,7139,84701,7170,477,1345	ATP1B1,ATP1B3,COX6B1,CACNB4,COX7B2,CACNB3,COX7B,COX5A,UQCRC2,CACNG3,ATP1A3,COX8A,CYC1,CACNB2,UQCRH,UQCRQ,ATP1A1,UQCR11,COX6A2,UQCRC1,COX6B2,COX4I1,SLC8A1,COX7A1,TNNT2,COX4I2,TPM3,ATP1A2,COX6C
hsa04260	Cardiac muscle contraction	0.225121029888806	-1.49111711078286	74	29	0.0117742590336987	2463	7161	84701,7139,1345,477,7170,125965,1327,7384,1346,6546,1339,783,7388,27089,1537,10975,476,1351,10368,478,9377,1349,7385,785,1340,481,483,784,170712	COX4I2,TNNT2,COX6C,ATP1A2,TPM3,COX6B2,COX4I1,UQCRC1,COX7A1,SLC8A1,COX6A2,CACNB2,UQCRH,UQCRQ,CYC1,UQCR11,ATP1A1,COX8A,CACNG3,ATP1A3,COX5A,COX7B,UQCRC2,CACNB4,COX6B1,ATP1B1,ATP1B3,CACNB3,COX7B2
ko04918	Thyroid hormone synthesis	0.225121029888806	-1.49111711078286	74	29	0.0117742590336987	2463	7161	108,2880,478,7184,5579,2877,10488,7276,5578,405753,483,481,2876,3309,1385,477,5330,109,7253,2776,257202,23236,213,476,5567,2878,148327,468,2882	ADCY2,GPX5,ATP1A3,HSP90B1,PRKCB,GPX2,CREB3,TTR,PRKCA,DUOXA2,ATP1B3,ATP1B1,GPX1,HSPA5,CREB1,ATP1A2,PLCB2,ADCY3,TSHR,GNAQ,GPX6,PLCB1,ALB,ATP1A1,PRKACB,GPX3,CREB3L4,ATF4,GPX7
hsa04918	Thyroid hormone synthesis	0.225121029888806	-1.49111711078286	74	29	0.0117742590336987	2463	7161	2876,3309,481,483,405753,5578,10488,7276,5579,7184,478,2877,108,2880,468,2882,148327,476,2878,5567,213,23236,2776,257202,109,5330,7253,1385,477	GPX1,HSPA5,ATP1B1,ATP1B3,DUOXA2,PRKCA,CREB3,TTR,PRKCB,HSP90B1,ATP1A3,GPX2,ADCY2,GPX5,ATF4,GPX7,CREB3L4,ATP1A1,GPX3,PRKACB,ALB,PLCB1,GNAQ,GPX6,ADCY3,PLCB2,TSHR,CREB1,ATP1A2
hsa_M00071	Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	2683,8702,8703	B4GALT1,B4GALT4,B4GALT3
M00414	Bloom's syndrome complex	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	116028,8940,80010	RMI2,TOP3B,RMI1
M00405	THC complex	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	9984,79228,57187	THOC1,THOC6,THOC2
hsa_M00414	Bloom's syndrome complex	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	80010,116028,8940	RMI1,RMI2,TOP3B
M00037	Melatonin biosynthesis, tryptophan => serotonin => melatonin	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	438,121278,15	ASMT,TPH2,AANAT
hsa_M00307	Pyruvate oxidation, pyruvate => acetyl-CoA	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	1737,5162,5160	DLAT,PDHB,PDHA1
hsa_M00405	THC complex	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	9984,79228,57187	THOC1,THOC6,THOC2
M00071	Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	2683,8702,8703	B4GALT1,B4GALT4,B4GALT3
M00307	Pyruvate oxidation, pyruvate => acetyl-CoA	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	5162,1737,5160	PDHB,DLAT,PDHA1
hsa_M00037	Melatonin biosynthesis, tryptophan => serotonin => melatonin	0.22577921802099	-1.48819766861036	5	3	0.00121802679658952	2463	7161	438,121278,15	ASMT,TPH2,AANAT
ko05130	Pathogenic Escherichia coli infection	0.22893619875518	-1.47431192230232	55	22	0.00893219650832318	2463	7161	10094,9475,60,10383,9076,5578,4690,7100,203068,6093,3059,8976,7099,7846,23643,10109,1499,929,2017,998,7534,10376	ARPC3,ROCK2,ACTB,TUBB4B,CLDN1,PRKCA,NCK1,TLR5,TUBB,ROCK1,HCLS1,WASL,TLR4,TUBA1A,LY96,ARPC2,CTNNB1,CD14,CTTN,CDC42,YWHAZ,TUBA1B
hsa05130	Pathogenic Escherichia coli infection	0.22893619875518	-1.47431192230232	55	22	0.00893219650832318	2463	7161	5578,10383,60,9076,10094,9475,7099,3059,6093,8976,203068,7100,4690,929,1499,10109,7846,23643,10376,7534,998,2017	PRKCA,TUBB4B,ACTB,CLDN1,ARPC3,ROCK2,TLR4,HCLS1,ROCK1,WASL,TUBB,TLR5,NCK1,CD14,CTNNB1,ARPC2,TUBA1A,LY96,TUBA1B,YWHAZ,CDC42,CTTN
hsa00603	Glycosphingolipid biosynthesis - globo and isoglobo series	0.229210877294856	-1.47311283761119	15	7	0.00284206252537556	2463	7161	8706,3073,10690,2523,6482,6483,3074	B3GALNT1,HEXA,FUT9,FUT1,ST3GAL1,ST3GAL2,HEXB
M00059	Glycosaminoglycan biosynthesis, heparan sulfate backbone	0.235240828093306	-1.44714548919038	10	5	0.00203004466098254	2463	7161	26035,9348,3340,2131,2135	GLCE,NDST3,NDST1,EXT1,EXTL2
hsa_M00059	Glycosaminoglycan biosynthesis, heparan sulfate backbone	0.235240828093306	-1.44714548919038	10	5	0.00203004466098254	2463	7161	9348,26035,2135,2131,3340	NDST3,GLCE,EXTL2,EXT1,NDST1
ko01040	Biosynthesis of unsaturated fatty acids	0.239029996767099	-1.43116622544051	23	10	0.00406008932196508	2463	7161	51,3030,9200,201562,9415,51495,9524,401494,79966,79071	ACOX1,HADHA,HACD1,HACD2,FADS2,HACD3,TECR,HACD4,SCD5,ELOVL6
hsa04964	Proximal tubule bicarbonate reclamation	0.239029996767099	-1.43116622544051	23	10	0.00406008932196508	2463	7161	10991,1468,477,4190,483,481,760,5106,478,476	SLC38A3,SLC25A10,ATP1A2,MDH1,ATP1B3,ATP1B1,CA2,PCK2,ATP1A3,ATP1A1
hsa01040	Biosynthesis of unsaturated fatty acids	0.239029996767099	-1.43116622544051	23	10	0.00406008932196508	2463	7161	201562,9200,3030,51,79071,79966,401494,9524,51495,9415	HACD2,HACD1,HADHA,ACOX1,ELOVL6,SCD5,HACD4,TECR,HACD3,FADS2
ko00515	Mannose type O-glycan biosynthesis	0.239029996767099	-1.43116622544051	23	10	0.00406008932196508	2463	7161	29954,10690,11041,9486,2218,8703,79147,2683,9215,146664	POMT2,FUT9,B4GAT1,CHST10,FKTN,B4GALT3,FKRP,B4GALT1,LARGE1,MGAT5B
hsa00515	Mannose type O-glycan biosynthesis	0.239029996767099	-1.43116622544051	23	10	0.00406008932196508	2463	7161	9215,8703,2683,79147,146664,10690,11041,29954,2218,9486	LARGE1,B4GALT3,B4GALT1,FKRP,MGAT5B,FUT9,B4GAT1,POMT2,FKTN,CHST10
ko04964	Proximal tubule bicarbonate reclamation	0.239029996767099	-1.43116622544051	23	10	0.00406008932196508	2463	7161	10991,477,1468,4190,481,483,760,5106,478,476	SLC38A3,ATP1A2,SLC25A10,MDH1,ATP1B1,ATP1B3,CA2,PCK2,ATP1A3,ATP1A1
ko05330	Allograft rejection	0.265673439268811	-1.32548739632872	37	15	0.00609013398294762	2463	7161	3458,355,3565,941,3592,3593,3558,958,3586,3567,7124,942,959,356,940	IFNG,FAS,IL4,CD80,IL12A,IL12B,IL2,CD40,IL10,IL5,TNF,CD86,CD40LG,FASLG,CD28
hsa05330	Allograft rejection	0.265673439268811	-1.32548739632872	37	15	0.00609013398294762	2463	7161	355,3458,3565,941,7124,942,959,356,940,3558,3593,3592,958,3586,3567	FAS,IFNG,IL4,CD80,TNF,CD86,CD40LG,FASLG,CD28,IL2,IL12B,IL12A,CD40,IL10,IL5
ko04622	RIG-I-like receptor signaling pathway	0.267455092853322	-1.31880360392287	70	27	0.0109622411693057	2463	7161	3456,29110,23586,4790,3446,64135,80143,7189,3447,7124,9636,3665,10010,3627,64343,57506,5602,7186,3551,3440,3576,3661,4793,4792,56832,3592,3593	IFNB1,TBK1,RIGI,NFKB1,IFNA10,IFIH1,SIKE1,TRAF6,IFNA13,TNF,ISG15,IRF7,TANK,CXCL10,AZI2,MAVS,MAPK10,TRAF2,IKBKB,IFNA2,CXCL8,IRF3,NFKBIB,NFKBIA,IFNK,IL12A,IL12B
hsa04622	RIG-I-like receptor signaling pathway	0.267455092853322	-1.31880360392287	70	27	0.0109622411693057	2463	7161	3593,3592,56832,4792,4793,3661,3576,3551,3440,7186,5602,57506,64343,3627,10010,3665,9636,7124,3447,7189,64135,80143,3446,4790,23586,29110,3456	IL12B,IL12A,IFNK,NFKBIA,NFKBIB,IRF3,CXCL8,IKBKB,IFNA2,TRAF2,MAPK10,MAVS,AZI2,CXCL10,TANK,IRF7,ISG15,TNF,IFNA13,TRAF6,IFIH1,SIKE1,IFNA10,NFKB1,RIGI,TBK1,IFNB1
ko03450	Non-homologous end-joining	0.268076350319455	-1.31648344979282	13	6	0.00243605359317905	2463	7161	1791,64421,2237,79840,7520,27343	DNTT,DCLRE1C,FEN1,NHEJ1,XRCC5,POLL
hsa03450	Non-homologous end-joining	0.268076350319455	-1.31648344979282	13	6	0.00243605359317905	2463	7161	27343,7520,2237,79840,1791,64421	POLL,XRCC5,FEN1,NHEJ1,DNTT,DCLRE1C
ko05222	Small cell lung cancer	0.270980984395311	-1.30570662884733	84	32	0.0129922858302883	2463	7161	6258,8503,5290,1027,1019,208,3913,7189,10000,3673,4790,4609,1164,1163,7185,4792,2272,598,7186,329,3551,5925,595,3685,5295,1021,4149,5728,3655,7157,5296,207	RXRG,PIK3R3,PIK3CA,CDKN1B,CDK4,AKT2,LAMB2,TRAF6,AKT3,ITGA2,NFKB1,MYC,CKS2,CKS1B,TRAF1,NFKBIA,FHIT,BCL2L1,TRAF2,BIRC2,IKBKB,RB1,CCND1,ITGAV,PIK3R1,CDK6,MAX,PTEN,ITGA6,TP53,PIK3R2,AKT1
hsa05222	Small cell lung cancer	0.270980984395311	-1.30570662884733	84	32	0.0129922858302883	2463	7161	4792,1163,7185,2272,7186,329,598,3551,595,5925,1021,3685,5295,4149,3655,5728,5296,7157,207,6258,8503,5290,1027,1019,3913,208,7189,10000,3673,4609,4790,1164	NFKBIA,CKS1B,TRAF1,FHIT,TRAF2,BIRC2,BCL2L1,IKBKB,CCND1,RB1,CDK6,ITGAV,PIK3R1,MAX,ITGA6,PTEN,PIK3R2,TP53,AKT1,RXRG,PIK3R3,PIK3CA,CDKN1B,CDK4,LAMB2,AKT2,TRAF6,AKT3,ITGA2,MYC,NFKB1,CKS2
hsa04726	Serotonergic synapse	0.273146295652908	-1.29774774581791	112	42	0.0170523751522534	2463	7161	55970,5578,2787,2561,2790,3760,5604,7220,6532,2771,3350,2791,54331,121278,5579,2785,2782,2784,3356,3265,1562,2562,1559,3751,51764,1565,23236,100137049,3355,5894,5567,1843,3845,2788,2773,2793,2775,59345,5330,1558,2776,3361	GNG12,PRKCA,GNG5,GABRB2,GNG10,KCNJ3,MAP2K1,TRPC1,SLC6A4,GNAI2,HTR1A,GNG11,GNG2,TPH2,PRKCB,GNG3,GNB1,GNB3,HTR2A,HRAS,CYP2C18,GABRB3,CYP2C9,KCND2,GNG13,CYP2D6,PLCB1,PLA2G4B,HTR1F,RAF1,PRKACB,DUSP1,KRAS,GNG7,GNAI3,GNGT2,GNAO1,GNB4,PLCB2,CYP2C8,GNAQ,HTR5A
M00134	Polyamine biosynthesis, arginine => ornithine => putrescine	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	384,4953	ARG2,ODC1
ko00785	Lipoic acid metabolism	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	387787,11019	LIPT2,LIAS
M00069	Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	29906,8869	ST8SIA5,ST3GAL5
hsa00785	Lipoic acid metabolism	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	11019,387787	LIAS,LIPT2
M00082	Fatty acid biosynthesis, initiation	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	31,27349	ACACA,MCAT
hsa_M00069	Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	29906,8869	ST8SIA5,ST3GAL5
hsa_M00082	Fatty acid biosynthesis, initiation	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	31,27349	ACACA,MCAT
hsa_M00134	Polyamine biosynthesis, arginine => ornithine => putrescine	0.273490715270577	-1.29648760551873	3	2	0.000812017864393017	2463	7161	4953,384	ODC1,ARG2
ko04122	Sulfur relay system	0.28063761807058	-1.27069105732514	8	4	0.00162403572878603	2463	7161	7263,4357,90353,81605	TST,MPST,CTU1,URM1
hsa04122	Sulfur relay system	0.28063761807058	-1.27069105732514	8	4	0.00162403572878603	2463	7161	7263,4357,90353,81605	TST,MPST,CTU1,URM1
hsa04924	Renin secretion	0.284002781370318	-1.25877124731143	65	25	0.0101502233049127	2463	7161	154,5153,3778,155,1179,1909,5972,5734,2771,5530,5535,153,134,23236,5136,5567,5732,2983,1508,1385,3759,2773,5330,51806,2776	ADRB2,PDE1B,KCNMA1,ADRB3,CLCA1,EDNRA,REN,PTGER4,GNAI2,PPP3CA,PPP3R2,ADRB1,ADORA1,PLCB1,PDE1A,PRKACB,PTGER2,GUCY1B1,CTSB,CREB1,KCNJ2,GNAI3,PLCB2,CALML5,GNAQ
hsa05230	Central carbon metabolism in cancer	0.284002781370318	-1.25877124731143	65	25	0.0101502233049127	2463	7161	4233,207,7157,5296,5728,3845,5162,5295,5894,3417,3265,3939,4609,10000,208,5604,4916,3815,6513,5290,5160,5223,2260,8503,2539	MET,AKT1,TP53,PIK3R2,PTEN,KRAS,PDHB,PIK3R1,RAF1,IDH1,HRAS,LDHA,MYC,AKT3,AKT2,MAP2K1,NTRK3,KIT,SLC2A1,PIK3CA,PDHA1,PGAM1,FGFR1,PIK3R3,G6PD
ko05230	Central carbon metabolism in cancer	0.284002781370318	-1.25877124731143	65	25	0.0101502233049127	2463	7161	2260,8503,2539,5160,5290,5223,208,5604,6513,3815,4916,4609,10000,3265,3939,3417,5894,3845,5728,5162,5295,4233,207,5296,7157	FGFR1,PIK3R3,G6PD,PDHA1,PIK3CA,PGAM1,AKT2,MAP2K1,SLC2A1,KIT,NTRK3,MYC,AKT3,HRAS,LDHA,IDH1,RAF1,KRAS,PTEN,PDHB,PIK3R1,MET,AKT1,PIK3R2,TP53
ko04924	Renin secretion	0.284002781370318	-1.25877124731143	65	25	0.0101502233049127	2463	7161	1179,1909,154,5153,155,3778,5530,5972,2771,5734,5567,5136,2983,5732,1508,5535,153,23236,134,5330,51806,2776,1385,3759,2773	CLCA1,EDNRA,ADRB2,PDE1B,ADRB3,KCNMA1,PPP3CA,REN,GNAI2,PTGER4,PRKACB,PDE1A,GUCY1B1,PTGER2,CTSB,PPP3R2,ADRB1,PLCB1,ADORA1,PLCB2,CALML5,GNAQ,CREB1,KCNJ2,GNAI3
ko04136	Autophagy - other	0.28448478064064	-1.25707552195865	32	13	0.00527811611855461	2463	7161	23710,10533,5516,8678,115201,60673,11337,79065,3476,64422,84938,55054,11345	GABARAPL1,ATG7,PPP2CB,BECN1,ATG4A,ATG101,GABARAP,ATG9A,IGBP1,ATG3,ATG4C,ATG16L1,GABARAPL2
hsa04136	Autophagy - other	0.28448478064064	-1.25707552195865	32	13	0.00527811611855461	2463	7161	5516,10533,23710,8678,60673,115201,11337,79065,55054,84938,64422,3476,11345	PPP2CB,ATG7,GABARAPL1,BECN1,ATG101,ATG4A,GABARAP,ATG9A,ATG16L1,ATG4C,ATG3,IGBP1,GABARAPL2
hsa00640	Propanoate metabolism	0.28448478064064	-1.25707552195865	32	13	0.00527811611855461	2463	7161	3939,3030,1629,31,55902,92483,5096,38,3945,55862,4594,8801,1962	LDHA,HADHA,DBT,ACACA,ACSS2,LDHAL6B,PCCB,ACAT1,LDHB,ECHDC1,MMUT,SUCLG2,EHHADH
ko00640	Propanoate metabolism	0.28448478064064	-1.25707552195865	32	13	0.00527811611855461	2463	7161	5096,38,3945,55862,4594,8801,1962,3939,3030,1629,31,55902,92483	PCCB,ACAT1,LDHB,ECHDC1,MMUT,SUCLG2,EHHADH,LDHA,HADHA,DBT,ACACA,ACSS2,LDHAL6B
ko04940	Type I diabetes mellitus	0.287183105055498	-1.24763526994684	43	17	0.00690215184734064	2463	7161	2572,941,3458,355,1363,4049,3558,3592,3593,940,3382,3553,3552,356,942,3329,7124	GAD2,CD80,IFNG,FAS,CPE,LTA,IL2,IL12A,IL12B,CD28,ICA1,IL1B,IL1A,FASLG,CD86,HSPD1,TNF
hsa04940	Type I diabetes mellitus	0.287183105055498	-1.24763526994684	43	17	0.00690215184734064	2463	7161	3593,3558,3592,1363,4049,942,3329,7124,3552,356,3553,940,3382,3458,355,2572,941	IL12B,IL2,IL12A,CPE,LTA,CD86,HSPD1,TNF,IL1A,FASLG,IL1B,CD28,ICA1,IFNG,FAS,GAD2,CD80
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.290882872147003	-1.23483459404905	24	10	0.00406008932196508	2463	7161	26035,9957,2135,3340,2131,11285,9653,9348,222537,9955	GLCE,HS3ST1,EXTL2,NDST1,EXT1,B4GALT7,HS2ST1,NDST3,HS3ST5,HS3ST3A1
hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	0.290882872147003	-1.23483459404905	24	10	0.00406008932196508	2463	7161	26035,9957,2135,3340,2131,11285,9653,9348,9955,222537	GLCE,HS3ST1,EXTL2,NDST1,EXT1,B4GALT7,HS2ST1,NDST3,HS3ST3A1,HS3ST5
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	0.290987720003026	-1.23447421200338	68	26	0.0105562322371092	2463	7161	51382,3725,6352,533,50848,4790,8992,1445,90423,528,534,3577,1839,998,2919,4233,4792,6714,5781,523,5602,9550,3551,9020,5803,3576	ATP6V1D,JUN,CCL5,ATP6V0B,F11R,NFKB1,ATP6V0E1,CSK,ATP6V1E2,ATP6V1C1,ATP6V1G2,CXCR1,HBEGF,CDC42,CXCL1,MET,NFKBIA,SRC,PTPN11,ATP6V1A,MAPK10,ATP6V1G1,IKBKB,MAP3K14,PTPRZ1,CXCL8
ko05120	Epithelial cell signaling in Helicobacter pylori infection	0.290987720003026	-1.23447421200338	68	26	0.0105562322371092	2463	7161	50848,4790,51382,3725,6352,533,1445,90423,528,8992,3577,1839,998,2919,4233,534,5781,5602,9550,523,3551,9020,5803,3576,4792,6714	F11R,NFKB1,ATP6V1D,JUN,CCL5,ATP6V0B,CSK,ATP6V1E2,ATP6V1C1,ATP6V0E1,CXCR1,HBEGF,CDC42,CXCL1,MET,ATP6V1G2,PTPN11,MAPK10,ATP6V1G1,ATP6V1A,IKBKB,MAP3K14,PTPRZ1,CXCL8,NFKBIA,SRC
M00075	N-glycan biosynthesis, complex type	0.293411633241859	-1.22617876429153	16	7	0.00284206252537556	2463	7161	6480,11282,11320,146664,2530,8703,2683	ST6GAL1,MGAT4B,MGAT4A,MGAT5B,FUT8,B4GALT3,B4GALT1
hsa_M00075	N-glycan biosynthesis, complex type	0.293411633241859	-1.22617876429153	16	7	0.00284206252537556	2463	7161	11320,11282,6480,2683,8703,146664,2530	MGAT4A,MGAT4B,ST6GAL1,B4GALT1,B4GALT3,MGAT5B,FUT8
hsa_M00682	Notch signaling	0.293411633241859	-1.22617876429153	16	7	0.00284206252537556	2463	7161	51107,3516,5664,5663,4853,23385,55851	APH1A,RBPJ,PSEN2,PSEN1,NOTCH2,NCSTN,PSENEN
M00682	Notch signaling	0.293411633241859	-1.22617876429153	16	7	0.00284206252537556	2463	7161	23385,5664,51107,3516,55851,5663,4853	NCSTN,PSEN2,APH1A,RBPJ,PSENEN,PSEN1,NOTCH2
hsa05020	Prion diseases	0.296637155094752	-1.21524558708095	35	14	0.00568412505075112	2463	7161	5621,5567,3553,3552,3569,3309,581,1958,714,5604,6647,2002,6352,100506742	PRNP,PRKACB,IL1B,IL1A,IL6,HSPA5,BAX,EGR1,C1QC,MAP2K1,SOD1,ELK1,CCL5,CASP12
ko05020	Prion diseases	0.296637155094752	-1.21524558708095	35	14	0.00568412505075112	2463	7161	1958,3552,3553,3569,3309,581,5621,5567,100506742,5604,714,6647,2002,6352	EGR1,IL1A,IL1B,IL6,HSPA5,BAX,PRNP,PRKACB,CASP12,MAP2K1,C1QC,SOD1,ELK1,CCL5
ko05132	Salmonella infection	0.298624746172484	-1.20856752332402	85	32	0.0129922858302883	2463	7161	391,29108,60,64837,3569,7100,3552,3553,8976,6093,10109,3725,4615,4790,2921,9475,10094,1780,3459,5602,3576,388372,7099,3606,2353,1437,929,1781,998,6348,2919,3458	RHOG,PYCARD,ACTB,KLC2,IL6,TLR5,IL1A,IL1B,WASL,ROCK1,ARPC2,JUN,MYD88,NFKB1,CXCL3,ROCK2,ARPC3,DYNC1I1,IFNGR1,MAPK10,CXCL8,CCL4L1,TLR4,IL18,FOS,CSF2,CD14,DYNC1I2,CDC42,CCL3,CXCL1,IFNG
hsa05132	Salmonella infection	0.298624746172484	-1.20856752332402	85	32	0.0129922858302883	2463	7161	3725,10109,2921,4790,4615,64837,60,29108,391,6093,8976,3553,3552,7100,3569,929,1437,2353,3458,6348,2919,998,1781,3459,1780,10094,9475,388372,3606,7099,3576,5602	JUN,ARPC2,CXCL3,NFKB1,MYD88,KLC2,ACTB,PYCARD,RHOG,ROCK1,WASL,IL1B,IL1A,TLR5,IL6,CD14,CSF2,FOS,IFNG,CCL3,CXCL1,CDC42,DYNC1I2,IFNGR1,DYNC1I1,ARPC3,ROCK2,CCL4L1,IL18,TLR4,CXCL8,MAPK10
ko04530	Tight junction	0.308208935620662	-1.17697736358759	170	62	0.0251725537961835	2463	7161	6093,5571,50855,10097,5010,5111,4637,1365,53842,4771,861,50848,912,3725,1019,5522,5872,910,4620,595,4619,5602,7074,92359,9076,5581,10376,909,9080,51762,998,81,57180,8976,5564,103910,57826,1739,5518,11149,60,4478,10627,9074,7846,100132463,5516,3059,5567,9073,6794,9368,6714,9475,23562,5906,911,913,1080,2017,1741,1364	ROCK1,PRKAG1,PARD6A,ACTR2,CLDN11,PCNA,MYL6,CLDN3,CLDN22,NF2,RUNX1,F11R,CD1D,JUN,CDK4,PPP2R2C,RAB13,CD1B,MYH2,CCND1,MYH1,MAPK10,TIAM1,CRB3,CLDN1,PRKCE,TUBA1B,CD1A,CLDN9,RAB8B,CDC42,ACTN4,ACTR3B,WASL,PRKAB1,MYL12B,RAP2C,DLG1,PPP2R1A,BVES,ACTB,MSN,MYL12A,CLDN6,TUBA1A,CLDN24,PPP2CB,HCLS1,PRKACB,CLDN8,STK11,NHERF1,SRC,ROCK2,CLDN14,RAP1A,CD1C,CD1E,CFTR,CTTN,DLG3,CLDN4
hsa04530	Tight junction	0.308208935620662	-1.17697736358759	170	62	0.0251725537961835	2463	7161	1364,2017,1741,1080,23562,913,911,5906,9475,6714,6794,9368,9073,5567,5516,3059,100132463,7846,9074,10627,4478,60,11149,5518,1739,57826,103910,8976,5564,57180,81,998,51762,909,10376,9080,5581,9076,7074,92359,5602,4619,595,5872,910,4620,1019,5522,3725,912,50848,861,53842,4771,1365,5111,4637,5571,10097,50855,5010,6093	CLDN4,CTTN,DLG3,CFTR,CLDN14,CD1E,CD1C,RAP1A,ROCK2,SRC,STK11,NHERF1,CLDN8,PRKACB,PPP2CB,HCLS1,CLDN24,TUBA1A,CLDN6,MYL12A,MSN,ACTB,BVES,PPP2R1A,DLG1,RAP2C,MYL12B,WASL,PRKAB1,ACTR3B,ACTN4,CDC42,RAB8B,CD1A,TUBA1B,CLDN9,PRKCE,CLDN1,TIAM1,CRB3,MAPK10,MYH1,CCND1,RAB13,CD1B,MYH2,CDK4,PPP2R2C,JUN,CD1D,F11R,RUNX1,CLDN22,NF2,CLDN3,PCNA,MYL6,PRKAG1,ACTR2,PARD6A,CLDN11,ROCK1
hsa00230	Purine metabolism	0.311504712843198	-1.1663408113564	173	63	0.02557856272838	2463	7161	5438,6240,108,318,50808,55703,30834,4833,5145,5142,5152,84265,1633,5138,22875,9060,2987,4860,53343,5436,57804,84284,5150,5432,4831,5435,109,56985,51082,131870,5558,5136,2983,9583,5471,56655,204,26289,10621,5431,5147,5153,5425,646625,22978,8833,132,23649,5236,956,5441,4882,5631,51251,5433,11164,2272,4830,5151,54107,84172,159,171568	POLR2I,RRM1,ADCY2,NUDT2,AK3,POLR3B,POLR1H,NME4,PDE6A,PDE4B,PDE9A,POLR3GL,DCK,PDE2A,ENPP4,PAPSS2,GUK1,PNP,NUDT9,POLR2G,POLD4,NTPCR,PDE7A,POLR2C,NME2,POLR2F,ADCY3,ADPRM,POLR1D,NUDT16,PRIM2,PDE1A,GUCY1B1,ENTPD4,PPAT,POLE4,AK2,AK5,POLR3F,POLR2B,PDE6D,PDE1B,POLD2,URAD,NT5C2,GMPS,ADK,POLA2,PGM1,ENTPD3,POLR2L,NPR2,PRPS1,NT5C3A,POLR2D,NUDT5,FHIT,NME1,PDE8A,POLE3,POLR1B,ADSS2,POLR3H
ko00230	Purine metabolism	0.311504712843198	-1.1663408113564	173	63	0.02557856272838	2463	7161	5152,5142,5145,9060,22875,5138,1633,84265,108,6240,5438,4833,30834,55703,50808,318,131870,51082,56985,2983,5136,5558,84284,5436,4860,53343,57804,2987,109,5435,4831,5432,5150,5153,8833,22978,646625,5425,204,56655,5471,9583,5147,10621,5431,26289,5151,4830,2272,171568,159,84172,54107,956,5236,23649,132,5433,11164,51251,4882,5631,5441	PDE9A,PDE4B,PDE6A,PAPSS2,ENPP4,PDE2A,DCK,POLR3GL,ADCY2,RRM1,POLR2I,NME4,POLR1H,POLR3B,AK3,NUDT2,NUDT16,POLR1D,ADPRM,GUCY1B1,PDE1A,PRIM2,NTPCR,POLR2G,PNP,NUDT9,POLD4,GUK1,ADCY3,POLR2F,NME2,POLR2C,PDE7A,PDE1B,GMPS,NT5C2,URAD,POLD2,AK2,POLE4,PPAT,ENTPD4,PDE6D,POLR3F,POLR2B,AK5,PDE8A,NME1,FHIT,POLR3H,ADSS2,POLR1B,POLE3,ENTPD3,PGM1,POLA2,ADK,POLR2D,NUDT5,NT5C3A,NPR2,PRPS1,POLR2L
M00143	NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria	0.31587046745027	-1.15242306256464	11	5	0.00203004466098254	2463	7161	4726,4722,4720,4729,4728	NDUFS6,NDUFS3,NDUFS2,NDUFV2,NDUFS8
hsa_M00032	Lysine degradation, lysine => saccharopine => acetoacetyl-CoA	0.31587046745027	-1.15242306256464	11	5	0.00203004466098254	2463	7161	3030,1962,1743,55753,3033	HADHA,EHHADH,DLST,OGDHL,HADH
M00032	Lysine degradation, lysine => saccharopine => acetoacetyl-CoA	0.31587046745027	-1.15242306256464	11	5	0.00203004466098254	2463	7161	3033,1743,55753,1962,3030	HADH,DLST,OGDHL,EHHADH,HADHA
hsa_M00143	NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria	0.31587046745027	-1.15242306256464	11	5	0.00203004466098254	2463	7161	4728,4729,4720,4722,4726	NDUFS8,NDUFV2,NDUFS2,NDUFS3,NDUFS6
ko05202	Transcriptional misregulation in cancer	0.317938552306499	-1.14589714661419	179	65	0.026390580592773	2463	7161	2005,4291,7048,3486,25942,4609,4790,1649,4005,958,1848,6258,51274,1027,8350,3569,2530,2130,5546,7102,85414,1437,604,6760,4233,7157,8861,1236,7850,4208,5371,3576,3480,7030,8842,1025,26471,861,4086,1026,466,5468,8464,1031,1053,3560,597,7704,942,7709,3479,929,4149,171558,2120,3562,3728,6667,7185,4318,55204,1655,4193,2209,598	ELK4,MLF1,TGFBR2,IGFBP3,SIN3A,MYC,NFKB1,DDIT3,LMO2,CD40,DUSP6,RXRG,KLF3,CDKN1B,H3C1,IL6,FUT8,EWSR1,PRCC,TSPAN7,SLC45A3,CSF2,BCL6,SS18,MET,TP53,LDB1,CCR7,IL1R2,MEF2C,PML,CXCL8,IGF1R,TFE3,PROM1,CDK9,NUPR1,RUNX1,SMAD1,CDKN1A,ATF1,PPARG,SUPT3H,CDKN2C,CEBPE,IL2RB,BCL2A1,ZBTB16,CD86,ZBTB17,IGF1,CD14,MAX,PTCRA,ETV6,IL3,JUP,SP1,TRAF1,MMP9,GOLPH3L,DDX5,MDM2,FCGR1A,BCL2L1
hsa05202	Transcriptional misregulation in cancer	0.317938552306499	-1.14589714661419	179	65	0.026390580592773	2463	7161	7185,6667,1655,598,2209,4193,55204,4318,171558,929,4149,3728,2120,3562,597,3560,7704,5468,1053,1031,8464,7709,3479,942,1025,4086,466,1026,26471,861,7850,4208,1236,7030,3480,8842,3576,5371,1437,85414,6760,604,7102,7157,8861,4233,4005,6258,1848,958,2530,3569,2130,5546,1027,51274,8350,4291,2005,1649,7048,4609,4790,3486,25942	TRAF1,SP1,DDX5,BCL2L1,FCGR1A,MDM2,GOLPH3L,MMP9,PTCRA,CD14,MAX,JUP,ETV6,IL3,BCL2A1,IL2RB,ZBTB16,PPARG,CEBPE,CDKN2C,SUPT3H,ZBTB17,IGF1,CD86,CDK9,SMAD1,ATF1,CDKN1A,NUPR1,RUNX1,IL1R2,MEF2C,CCR7,TFE3,IGF1R,PROM1,CXCL8,PML,CSF2,SLC45A3,SS18,BCL6,TSPAN7,TP53,LDB1,MET,LMO2,RXRG,DUSP6,CD40,FUT8,IL6,EWSR1,PRCC,CDKN1B,KLF3,H3C1,MLF1,ELK4,DDIT3,TGFBR2,MYC,NFKB1,IGFBP3,SIN3A
ko04520	Adherens junction	0.328951066759435	-1.11184627253265	72	27	0.0109622411693057	2463	7161	60,5880,2260,1460,4087,8976,10810,1457,1499,5770,7048,1495,2033,4089,6714,117178,1496,1387,5819,3480,7525,81,998,1500,4233,4088,6591	ACTB,RAC2,FGFR1,CSNK2B,SMAD2,WASL,WASF3,CSNK2A1,CTNNB1,PTPN1,TGFBR2,CTNNA1,EP300,SMAD4,SRC,SSX2IP,CTNNA2,CREBBP,NECTIN2,IGF1R,YES1,ACTN4,CDC42,CTNND1,MET,SMAD3,SNAI2
hsa04520	Adherens junction	0.328951066759435	-1.11184627253265	72	27	0.0109622411693057	2463	7161	60,1460,2260,5880,4087,8976,1457,10810,1499,7048,5770,1495,6714,117178,2033,4089,3480,1387,1496,5819,7525,81,1500,998,6591,4233,4088	ACTB,CSNK2B,FGFR1,RAC2,SMAD2,WASL,CSNK2A1,WASF3,CTNNB1,TGFBR2,PTPN1,CTNNA1,SRC,SSX2IP,EP300,SMAD4,IGF1R,CREBBP,CTNNA2,NECTIN2,YES1,ACTN4,CTNND1,CDC42,SNAI2,MET,SMAD3
ko00900	Terpenoid backbone biosynthesis	0.330836834626122	-1.10612997189214	22	9	0.00365408038976857	2463	7161	38,10269,9986,3157,2342,4597,57107,116150,9453	ACAT1,ZMPSTE24,RCE1,HMGCS1,FNTB,MVD,PDSS2,NUS1,GGPS1
hsa00900	Terpenoid backbone biosynthesis	0.330836834626122	-1.10612997189214	22	9	0.00365408038976857	2463	7161	10269,38,9986,2342,3157,4597,57107,116150,9453	ZMPSTE24,ACAT1,RCE1,FNTB,HMGCS1,MVD,PDSS2,NUS1,GGPS1
hsa04961	Endocrine and other factor-regulated calcium reabsorption	0.335866459148252	-1.09104164103149	47	18	0.00730816077953715	2463	7161	481,483,7421,476,160,5567,23236,8766,5578,2776,1175,1785,1173,478,5579,6546,5330,477	ATP1B1,ATP1B3,VDR,ATP1A1,AP2A1,PRKACB,PLCB1,RAB11A,PRKCA,GNAQ,AP2S1,DNM2,AP2M1,ATP1A3,PRKCB,SLC8A1,PLCB2,ATP1A2
ko04961	Endocrine and other factor-regulated calcium reabsorption	0.335866459148252	-1.09104164103149	47	18	0.00730816077953715	2463	7161	477,1173,1785,1175,2776,6546,5330,478,5579,8766,23236,5578,7421,481,483,5567,476,160	ATP1A2,AP2M1,DNM2,AP2S1,GNAQ,SLC8A1,PLCB2,ATP1A3,PRKCB,RAB11A,PLCB1,PRKCA,VDR,ATP1B1,ATP1B3,PRKACB,ATP1A1,AP2A1
M00285	MCM complex	0.340698693053001	-1.07675679038656	6	3	0.00121802679658952	2463	7161	4173,4172,4175	MCM4,MCM3,MCM6
ko00750	Vitamin B6 metabolism	0.340698693053001	-1.07675679038656	6	3	0.00121802679658952	2463	7161	316,55163,493911	AOX1,PNPO,PHOSPHO2
hsa00750	Vitamin B6 metabolism	0.340698693053001	-1.07675679038656	6	3	0.00121802679658952	2463	7161	55163,493911,316	PNPO,PHOSPHO2,AOX1
hsa_M00285	MCM complex	0.340698693053001	-1.07675679038656	6	3	0.00121802679658952	2463	7161	4173,4172,4175	MCM4,MCM3,MCM6
M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate	0.341244723939354	-1.07515539358607	14	6	0.00243605359317905	2463	7161	6391,55753,1743,6390,4190,8801	SDHC,OGDHL,DLST,SDHB,MDH1,SUCLG2
hsa_M00011	Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate	0.341244723939354	-1.07515539358607	14	6	0.00243605359317905	2463	7161	6390,4190,55753,8801,6391,1743	SDHB,MDH1,OGDHL,SUCLG2,SDHC,DLST
hsa04720	Long-term potentiation	0.349341993828819	-1.05170391158185	67	25	0.0101502233049127	2463	7161	2033,5535,3265,23236,2891,5906,5567,5894,2911,468,1387,5500,5501,3845,5330,2890,2776,51806,818,5578,5908,5604,5502,5579,5530	EP300,PPP3R2,HRAS,PLCB1,GRIA2,RAP1A,PRKACB,RAF1,GRM1,ATF4,CREBBP,PPP1CB,PPP1CC,KRAS,PLCB2,GRIA1,GNAQ,CALML5,CAMK2G,PRKCA,RAP1B,MAP2K1,PPP1R1A,PRKCB,PPP3CA
ko04720	Long-term potentiation	0.349341993828819	-1.05170391158185	67	25	0.0101502233049127	2463	7161	3845,5501,2776,51806,5330,2890,23236,2891,5906,2033,5535,3265,2911,1387,468,5500,5567,5894,5604,5502,5530,5579,818,5578,5908	KRAS,PPP1CC,GNAQ,CALML5,PLCB2,GRIA1,PLCB1,GRIA2,RAP1A,EP300,PPP3R2,HRAS,GRM1,CREBBP,ATF4,PPP1CB,PRKACB,RAF1,MAP2K1,PPP1R1A,PPP3CA,PRKCB,CAMK2G,PRKCA,RAP1B
hsa04350	TGF-beta signaling pathway	0.351422967157483	-1.04576474635105	84	31	0.0125862768980918	2463	7161	7042,7043,91,4093,3458,3400,1874,4088,130399,658,60436,6667,90,2033,4089,9241,1387,57154,5516,4086,7048,6500,4609,3397,4090,5518,659,657,7124,4087,6093	TGFB2,TGFB3,ACVR1B,SMAD9,IFNG,ID4,E2F4,SMAD3,ACVR1C,BMPR1B,TGIF2,SP1,ACVR1,EP300,SMAD4,NOG,CREBBP,SMURF1,PPP2CB,SMAD1,TGFBR2,SKP1,MYC,ID1,SMAD5,PPP2R1A,BMPR2,BMPR1A,TNF,SMAD2,ROCK1
ko04350	TGF-beta signaling pathway	0.351422967157483	-1.04576474635105	84	31	0.0125862768980918	2463	7161	4609,3397,7048,6500,4086,4087,6093,7124,657,5518,659,4090,1874,4088,3458,3400,4093,91,7042,7043,5516,57154,1387,9241,6667,90,2033,4089,130399,60436,658	MYC,ID1,TGFBR2,SKP1,SMAD1,SMAD2,ROCK1,TNF,BMPR1A,PPP2R1A,BMPR2,SMAD5,E2F4,SMAD3,IFNG,ID4,SMAD9,ACVR1B,TGFB2,TGFB3,PPP2CB,SMURF1,CREBBP,NOG,SP1,ACVR1,EP300,SMAD4,ACVR1C,TGIF2,BMPR1B
hsa_M00181	RNA polymerase III, eukaryotes	0.360823774802929	-1.01936559827802	17	7	0.00284206252537556	2463	7161	171568,5435,55703,10621,84265,5441,51082	POLR3H,POLR2F,POLR3B,POLR3F,POLR3GL,POLR2L,POLR1D
M00181	RNA polymerase III, eukaryotes	0.360823774802929	-1.01936559827802	17	7	0.00284206252537556	2463	7161	51082,5441,84265,10621,55703,5435,171568	POLR1D,POLR2L,POLR3GL,POLR3F,POLR3B,POLR2F,POLR3H
hsa04666	Fc gamma R-mediated phagocytosis	0.361405177490385	-1.01775557472191	90	33	0.0133982947624848	2463	7161	1072,1073,2209,1399,5894,2212,2213,5581,8394,100137049,7410,10094,998,5296,207,5295,382,56848,6850,8976,5290,8503,5578,5880,1785,65108,10000,3636,5579,10109,10810,5604,208	CFL1,CFL2,FCGR1A,CRKL,RAF1,FCGR2A,FCGR2B,PRKCE,PIP5K1A,PLA2G4B,VAV2,ARPC3,CDC42,PIK3R2,AKT1,PIK3R1,ARF6,SPHK2,SYK,WASL,PIK3CA,PIK3R3,PRKCA,RAC2,DNM2,MARCKSL1,AKT3,INPPL1,PRKCB,ARPC2,WASF3,MAP2K1,AKT2
ko04666	Fc gamma R-mediated phagocytosis	0.361405177490385	-1.01775557472191	90	33	0.0133982947624848	2463	7161	5880,5578,8503,8976,5290,10810,10109,208,5604,10000,1785,65108,5579,3636,100137049,7410,10094,8394,5581,1399,2209,1072,1073,2213,2212,5894,5295,382,6850,56848,998,5296,207	RAC2,PRKCA,PIK3R3,WASL,PIK3CA,WASF3,ARPC2,AKT2,MAP2K1,AKT3,DNM2,MARCKSL1,PRKCB,INPPL1,PLA2G4B,VAV2,ARPC3,PIP5K1A,PRKCE,CRKL,FCGR1A,CFL1,CFL2,FCGR2B,FCGR2A,RAF1,PIK3R1,ARF6,SYK,SPHK2,CDC42,PIK3R2,AKT1
hsa03008	Ribosome biogenesis in eukaryotes	0.37183926385459	-0.989293604497614	79	29	0.0117742590336987	2463	7161	51077,29102,27341,5822,55781,55813,10885,1736,84135,138716,6949,7514,10436,1460,51367,28987,92856,55916,5901,25996,10171,55272,51602,1457,55651,29107,10199,10248,54913	FCF1,DROSHA,RRP7A,PWP2,RIOK2,UTP6,WDR3,DKC1,UTP15,RPP25L,TCOF1,XPO1,EMG1,CSNK2B,POP5,NOB1,IMP4,NXT2,RAN,REXO2,RCL1,IMP3,NOP58,CSNK2A1,NHP2,NXT1,MPHOSPH10,POP7,RPP25
ko03008	Ribosome biogenesis in eukaryotes	0.37183926385459	-0.989293604497614	79	29	0.0117742590336987	2463	7161	55651,29107,10199,54913,10248,10171,55272,51602,1457,92856,55916,25996,5901,10436,1460,51367,28987,138716,6949,7514,10885,1736,84135,29102,27341,55781,5822,55813,51077	NHP2,NXT1,MPHOSPH10,RPP25,POP7,RCL1,IMP3,NOP58,CSNK2A1,IMP4,NXT2,REXO2,RAN,EMG1,CSNK2B,POP5,NOB1,RPP25L,TCOF1,XPO1,WDR3,DKC1,UTP15,DROSHA,RRP7A,RIOK2,PWP2,UTP6,FCF1
hsa_M00131	Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	0.37592790845647	-0.978357886803869	9	4	0.00162403572878603	2463	7161	51763,54928,3613,3631	INPP5K,BPNT2,IMPA2,INPP4A
M00131	Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol	0.37592790845647	-0.978357886803869	9	4	0.00162403572878603	2463	7161	3631,3613,54928,51763	INPP4A,IMPA2,BPNT2,INPP5K
ko00100	Steroid biosynthesis	0.376644030052054	-0.976454754956706	20	8	0.00324807145757207	2463	7161	120227,3988,2222,6307,10826,1594,6309,50814	CYP2R1,LIPA,FDFT1,MSMO1,FAXDC2,CYP27B1,SC5D,NSDHL
M00679	BMP signaling	0.376644030052054	-0.976454754956706	20	8	0.00324807145757207	2463	7161	657,4093,4086,659,4089,4090,90,658	BMPR1A,SMAD9,SMAD1,BMPR2,SMAD4,SMAD5,ACVR1,BMPR1B
hsa00100	Steroid biosynthesis	0.376644030052054	-0.976454754956706	20	8	0.00324807145757207	2463	7161	1594,10826,50814,6309,3988,120227,6307,2222	CYP27B1,FAXDC2,NSDHL,SC5D,LIPA,CYP2R1,MSMO1,FDFT1
hsa_M00679	BMP signaling	0.376644030052054	-0.976454754956706	20	8	0.00324807145757207	2463	7161	659,4086,4093,657,658,90,4089,4090	BMPR2,SMAD1,SMAD9,BMPR1A,BMPR1B,ACVR1,SMAD4,SMAD5
hsa04722	Neurotrophin signaling pathway	0.376645843155136	-0.97644994113099	119	43	0.0174583840844499	2463	7161	5602,468,1399,5781,3551,356,5894,4792,6464,4793,5906,2549,3265,51806,5296,998,7157,11108,51135,4215,207,5295,5664,3845,53358,581,5663,5290,572,6655,818,5908,8503,10000,27018,4915,4790,4909,4916,3725,208,5604,7189	MAPK10,ATF4,CRKL,PTPN11,IKBKB,FASLG,RAF1,NFKBIA,SHC1,NFKBIB,RAP1A,GAB1,HRAS,CALML5,PIK3R2,CDC42,TP53,PRDM4,IRAK4,MAP3K3,AKT1,PIK3R1,PSEN2,KRAS,SHC3,BAX,PSEN1,PIK3CA,BAD,SOS2,CAMK2G,RAP1B,PIK3R3,AKT3,BEX3,NTRK2,NFKB1,NTF4,NTRK3,JUN,AKT2,MAP2K1,TRAF6
ko04722	Neurotrophin signaling pathway	0.376645843155136	-0.97644994113099	119	43	0.0174583840844499	2463	7161	356,3551,1399,5781,5602,2549,4793,6464,207,4215,51135,5296,998,3845,5295,6655,572,5290,581,8503,818,4909,4915,27018,208,3725,4916,5894,468,3265,5906,4792,11108,7157,51806,53358,5664,5663,5908,4790,10000,7189,5604	FASLG,IKBKB,CRKL,PTPN11,MAPK10,GAB1,NFKBIB,SHC1,AKT1,MAP3K3,IRAK4,PIK3R2,CDC42,KRAS,PIK3R1,SOS2,BAD,PIK3CA,BAX,PIK3R3,CAMK2G,NTF4,NTRK2,BEX3,AKT2,JUN,NTRK3,RAF1,ATF4,HRAS,RAP1A,NFKBIA,PRDM4,TP53,CALML5,SHC3,PSEN2,PSEN1,RAP1B,NFKB1,AKT3,TRAF6,MAP2K1
hsa04978	Mineral absorption	0.38314181615492	-0.959350081170272	51	19	0.00771416971173366	2463	7161	2495,4499,79901,7421,481,483,4489,1317,476,4493,4891,4501,2512,4502,477,7018,6546,3163,478	FTH1,MT1M,CYBRD1,VDR,ATP1B1,ATP1B3,MT1A,SLC31A1,ATP1A1,MT1E,SLC11A2,MT1X,FTL,MT2A,ATP1A2,TF,SLC8A1,HMOX2,ATP1A3
ko04978	Mineral absorption	0.38314181615492	-0.959350081170272	51	19	0.00771416971173366	2463	7161	4489,476,1317,7421,483,481,4499,79901,2495,3163,478,6546,7018,477,2512,4502,4501,4493,4891	MT1A,ATP1A1,SLC31A1,VDR,ATP1B3,ATP1B1,MT1M,CYBRD1,FTH1,HMOX2,ATP1A3,SLC8A1,TF,ATP1A2,FTL,MT2A,MT1X,MT1E,SLC11A2
hsa04960	Aldosterone-regulated sodium reabsorption	0.387928962633753	-0.946933042116632	37	14	0.00568412505075112	2463	7161	8503,5578,483,481,3479,5290,476,5295,2810,3845,477,5296,5579,478	PIK3R3,PRKCA,ATP1B3,ATP1B1,IGF1,PIK3CA,ATP1A1,PIK3R1,SFN,KRAS,ATP1A2,PIK3R2,PRKCB,ATP1A3
ko04960	Aldosterone-regulated sodium reabsorption	0.387928962633753	-0.946933042116632	37	14	0.00568412505075112	2463	7161	483,481,3479,5290,476,5578,8503,5296,5579,478,2810,5295,3845,477	ATP1B3,ATP1B1,IGF1,PIK3CA,ATP1A1,PRKCA,PIK3R3,PIK3R2,PRKCB,ATP1A3,SFN,PIK3R1,KRAS,ATP1A2
M00355	Spliceosome, 35S U5-snRNP	0.387928962633753	-0.946933042116632	37	14	0.00568412505075112	2463	7161	51362,6628,27339,6637,9410,6634,51503,988,55696,3312,6633,6632,6635,8896	CDC40,SNRPB,PRPF19,SNRPG,SNRNP40,SNRPD3,CWC15,CDC5L,RBM22,HSPA8,SNRPD2,SNRPD1,SNRPE,BUD31
hsa_M00355	Spliceosome, 35S U5-snRNP	0.387928962633753	-0.946933042116632	37	14	0.00568412505075112	2463	7161	51362,6628,27339,51503,6634,9410,6637,988,55696,6635,3312,6632,6633,8896	CDC40,SNRPB,PRPF19,CWC15,SNRPD3,SNRNP40,SNRPG,CDC5L,RBM22,SNRPE,HSPA8,SNRPD1,SNRPD2,BUD31
hsa01200	Carbon metabolism	0.395266918395181	-0.928193999519751	114	41	0.0166463662200568	2463	7161	1737,55753,22934,2597,35,3417,8789,5096,5162,50,9104,5631,3420,6470,8277,2539,2875,5230,3419,6390,2098,3030,5223,275,55902,5160,38,2023,10993,4594,4190,6120,5091,6391,1743,2026,3418,48,2203,1962,8801	DLAT,OGDHL,RPIA,GAPDH,ACADS,IDH1,FBP2,PCCB,PDHB,ACO2,RGN,PRPS1,IDH3B,SHMT1,TKTL1,G6PD,GPT,PGK1,IDH3A,SDHB,ESD,HADHA,PGAM1,AMT,ACSS2,PDHA1,ACAT1,ENO1,SDS,MMUT,MDH1,RPE,PC,SDHC,DLST,ENO2,IDH2,ACO1,FBP1,EHHADH,SUCLG2
ko01200	Carbon metabolism	0.395266918395181	-0.928193999519751	114	41	0.0166463662200568	2463	7161	5162,5096,50,9104,5631,3420,6470,8277,55753,22934,1737,2597,35,8789,3417,38,2023,4594,4190,10993,6391,5091,1743,2026,6120,2203,1962,8801,48,3418,5230,2875,2539,6390,2098,3030,3419,275,5223,5160,55902	PDHB,PCCB,ACO2,RGN,PRPS1,IDH3B,SHMT1,TKTL1,OGDHL,RPIA,DLAT,GAPDH,ACADS,FBP2,IDH1,ACAT1,ENO1,MMUT,MDH1,SDS,SDHC,PC,DLST,ENO2,RPE,FBP1,EHHADH,SUCLG2,ACO1,IDH2,PGK1,GPT,G6PD,SDHB,ESD,HADHA,IDH3A,AMT,PGAM1,PDHA1,ACSS2
hsa_M00182	RNA polymerase I, eukaryotes	0.399016460389144	-0.918752608835071	12	5	0.00203004466098254	2463	7161	30834,5435,5441,84172,51082	POLR1H,POLR2F,POLR2L,POLR1B,POLR1D
M00182	RNA polymerase I, eukaryotes	0.399016460389144	-0.918752608835071	12	5	0.00203004466098254	2463	7161	30834,5435,51082,84172,5441	POLR1H,POLR2F,POLR1D,POLR1B,POLR2L
M00087	beta-Oxidation	0.399016460389144	-0.918752608835071	12	5	0.00203004466098254	2463	7161	3030,10449,1962,51,3033	HADHA,ACAA2,EHHADH,ACOX1,HADH
hsa_M00002	Glycolysis, core module involving three-carbon compounds	0.399016460389144	-0.918752608835071	12	5	0.00203004466098254	2463	7161	2023,5223,2026,5230,2597	ENO1,PGAM1,ENO2,PGK1,GAPDH
M00002	Glycolysis, core module involving three-carbon compounds	0.399016460389144	-0.918752608835071	12	5	0.00203004466098254	2463	7161	5223,2023,5230,2026,2597	PGAM1,ENO1,PGK1,ENO2,GAPDH
hsa_M00087	beta-Oxidation	0.399016460389144	-0.918752608835071	12	5	0.00203004466098254	2463	7161	3033,1962,10449,3030,51	HADH,EHHADH,ACAA2,HADHA,ACOX1
hsa04310	Wnt signaling pathway	0.404295118191426	-0.905610177126526	143	51	0.0207064555420219	2463	7161	6424,23002,7480,818,5880,896,1452,9350,7472,3725,7476,5579,23236,8607,8322,5602,1387,11197,4040,595,166336,50964,23291,5330,4088,5578,1460,5663,122011,1457,56998,22943,1499,1487,6477,2239,5530,4609,6500,9475,2033,5535,4089,8323,1856,5567,27101,1454,7157,6422,7976	SFRP4,DAAM1,WNT10B,CAMK2G,RAC2,CCND3,CSNK1A1,CER1,WNT2,JUN,WNT7A,PRKCB,PLCB1,RUVBL1,FZD4,MAPK10,CREBBP,WIF1,LRP6,CCND1,PRICKLE2,SOST,FBXW11,PLCB2,SMAD3,PRKCA,CSNK2B,PSEN1,CSNK1A1L,CSNK2A1,CTNNBIP1,DKK1,CTNNB1,CTBP1,SIAH1,GPC4,PPP3CA,MYC,SKP1,ROCK2,EP300,PPP3R2,SMAD4,FZD6,DVL2,PRKACB,CACYBP,CSNK1E,TP53,SFRP1,FZD3
hsa04514	Cell adhesion molecules (CAMs)	0.404295118191426	-0.905610177126526	143	51	0.0207064555420219	2463	7161	959,5819,3383,9073,1493,23562,1272,965,22871,6402,1364,941,3655,947,3685,90952,8506,920,4756,914,958,8174,214,3897,3384,9074,4359,57555,100132463,6385,3696,94030,3385,5133,9076,6900,9080,10666,80380,29126,257194,84628,942,5010,940,1365,53842,29851,50848,64101,6383	CD40LG,NECTIN2,ICAM1,CLDN8,CTLA4,CLDN14,CNTN1,CD58,NLGN1,SELL,CLDN4,CD80,ITGA6,CD34,ITGAV,ESAM,CNTNAP1,CD4,NEO1,CD2,CD40,MADCAM1,ALCAM,L1CAM,ICAM2,CLDN6,MPZ,NLGN2,CLDN24,SDC4,ITGB8,LRRC4B,ICAM3,PDCD1,CLDN1,CNTN2,CLDN9,CD226,PDCD1LG2,CD274,NEGR1,NTNG2,CD86,CLDN11,CD28,CLDN3,CLDN22,ICOS,F11R,LRRC4,SDC2
ko04310	Wnt signaling pathway	0.404295118191426	-0.905610177126526	143	51	0.0207064555420219	2463	7161	23291,5330,4088,50964,5602,1387,11197,166336,4040,595,23236,8322,8607,7476,5579,7472,3725,896,9350,1452,6424,7480,818,23002,5880,7157,7976,6422,1454,27101,5567,9475,8323,1856,5535,4089,2033,5530,2239,6477,6500,4609,1457,1487,1499,56998,22943,122011,5663,1460,5578	FBXW11,PLCB2,SMAD3,SOST,MAPK10,CREBBP,WIF1,PRICKLE2,LRP6,CCND1,PLCB1,FZD4,RUVBL1,WNT7A,PRKCB,WNT2,JUN,CCND3,CER1,CSNK1A1,SFRP4,WNT10B,CAMK2G,DAAM1,RAC2,TP53,FZD3,SFRP1,CSNK1E,CACYBP,PRKACB,ROCK2,FZD6,DVL2,PPP3R2,SMAD4,EP300,PPP3CA,GPC4,SIAH1,SKP1,MYC,CSNK2A1,CTBP1,CTNNB1,CTNNBIP1,DKK1,CSNK1A1L,PSEN1,CSNK2B,PRKCA
ko04514	Cell adhesion molecules (CAMs)	0.404295118191426	-0.905610177126526	143	51	0.0207064555420219	2463	7161	50848,64101,6383,5010,940,84628,257194,29126,942,53842,29851,1365,80380,9080,10666,3385,94030,9076,6900,5133,6385,3696,100132463,3384,9074,4359,57555,920,8506,3897,4756,914,958,8174,214,22871,6402,1364,941,965,3685,90952,3655,947,3383,5819,9073,959,1493,1272,23562	F11R,LRRC4,SDC2,CLDN11,CD28,NTNG2,NEGR1,CD274,CD86,CLDN22,ICOS,CLDN3,PDCD1LG2,CLDN9,CD226,ICAM3,LRRC4B,CLDN1,CNTN2,PDCD1,SDC4,ITGB8,CLDN24,ICAM2,CLDN6,MPZ,NLGN2,CD4,CNTNAP1,L1CAM,NEO1,CD2,CD40,MADCAM1,ALCAM,NLGN1,SELL,CLDN4,CD80,CD58,ITGAV,ESAM,ITGA6,CD34,ICAM1,NECTIN2,CLDN8,CD40LG,CTLA4,CNTN1,CLDN14
hsa04611	Platelet activation	0.40605029808289	-0.901278240150082	123	44	0.0178643930166464	2463	7161	10000,10627,3673,2771,108,208,10235,3937,64805,5290,4659,6093,1278,2815,5294,103910,2207,7450,60,5908,8503,8673,2776,5296,5330,109,207,5295,8773,2773,6850,5501,6786,1281,5500,2983,2212,5567,5028,23236,100137049,9475,5906,6714	AKT3,MYL12A,ITGA2,GNAI2,ADCY2,AKT2,RASGRP2,LCP2,P2RY12,PIK3CA,PPP1R12A,ROCK1,COL1A2,GP9,PIK3CG,MYL12B,FCER1G,VWF,ACTB,RAP1B,PIK3R3,VAMP8,GNAQ,PIK3R2,PLCB2,ADCY3,AKT1,PIK3R1,SNAP23,GNAI3,SYK,PPP1CC,STIM1,COL3A1,PPP1CB,GUCY1B1,FCGR2A,PRKACB,P2RY1,PLCB1,PLA2G4B,ROCK2,RAP1A,SRC
ko04146	Peroxisome	0.408100218978579	-0.896242499989832	83	30	0.0121802679658952	2463	7161	10005,5827,10901,8504,26063,728635,373156,84769,51,55711,6648,10478,3417,196743,2182,5264,5194,6647,5052,283927,3418,55670,1962,51555,390916,83594,1384,8443,23600,4358	ACOT8,PXMP2,DHRS4,PEX3,DECR2,DHRS4L1,GSTK1,MPV17L2,ACOX1,FAR2,SOD2,SLC25A17,IDH1,PAOX,ACSL4,PHYH,PEX13,SOD1,PRDX1,NUDT7,IDH2,PEX26,EHHADH,PEX5L,NUDT19,NUDT12,CRAT,GNPAT,AMACR,MPV17
hsa04146	Peroxisome	0.408100218978579	-0.896242499989832	83	30	0.0121802679658952	2463	7161	51,55711,6648,373156,84769,3417,10478,5827,10005,728635,10901,8504,26063,390916,83594,4358,1384,8443,23600,5264,5194,6647,5052,196743,2182,3418,55670,1962,51555,283927	ACOX1,FAR2,SOD2,GSTK1,MPV17L2,IDH1,SLC25A17,PXMP2,ACOT8,DHRS4L1,DHRS4,PEX3,DECR2,NUDT19,NUDT12,MPV17,CRAT,GNPAT,AMACR,PHYH,PEX13,SOD1,PRDX1,PAOX,ACSL4,IDH2,PEX26,EHHADH,PEX5L,NUDT7
ko05216	Thyroid cancer	0.411032155432495	-0.88908383048423	29	11	0.00446609825416159	2463	7161	4609,595,7157,3845,5468,5604,3265,1499,6258,7170,10342	MYC,CCND1,TP53,KRAS,PPARG,MAP2K1,HRAS,CTNNB1,RXRG,TPM3,TFG
hsa05216	Thyroid cancer	0.411032155432495	-0.88908383048423	29	11	0.00446609825416159	2463	7161	10342,7170,6258,5468,3265,5604,3845,1499,7157,4609,595	TFG,TPM3,RXRG,PPARG,HRAS,MAP2K1,KRAS,CTNNB1,TP53,MYC,CCND1
ko04024	cAMP signaling pathway	0.413230029883544	-0.883750867989401	198	70	0.0284206252537556	2463	7161	22800,5908,5142,1812,1909,108,5604,4790,478,51738,10000,2033,51,9475,4792,134,2891,5906,5732,5567,1128,5894,2550,64399,84152,5501,477,1385,2353,1080,27198,109,6662,51806,818,5880,154,8503,5290,6093,4659,493,572,483,481,3725,208,3350,2771,5350,10488,7074,7410,5021,153,476,3355,148327,5602,5465,1387,5500,4886,5295,2773,2890,4852,7253,207,5296	RRAS2,RAP1B,PDE4B,DRD1,EDNRA,ADCY2,MAP2K1,NFKB1,ATP1A3,GHRL,AKT3,EP300,ACOX1,ROCK2,NFKBIA,ADORA1,GRIA2,RAP1A,PTGER2,PRKACB,CHRM1,RAF1,GABBR1,HHIP,PPP1R1B,PPP1CC,ATP1A2,CREB1,FOS,CFTR,HCAR1,ADCY3,SOX9,CALML5,CAMK2G,RAC2,ADRB2,PIK3R3,PIK3CA,ROCK1,PPP1R12A,ATP2B4,BAD,ATP1B3,ATP1B1,JUN,AKT2,HTR1A,GNAI2,PLN,CREB3,TIAM1,VAV2,OXTR,ADRB1,ATP1A1,HTR1F,CREB3L4,MAPK10,PPARA,CREBBP,PPP1CB,NPY1R,PIK3R1,GNAI3,GRIA1,NPY,TSHR,AKT1,PIK3R2
hsa04024	cAMP signaling pathway	0.413230029883544	-0.883750867989401	198	70	0.0284206252537556	2463	7161	22800,5908,5142,1909,1812,5604,108,51738,4790,478,10000,51,2033,5906,9475,2891,134,4792,1128,5567,5894,5732,2550,5501,477,1385,64399,84152,2353,1080,27198,109,51806,6662,154,8503,818,5880,572,5290,6093,4659,493,481,483,3725,208,2771,3350,5350,10488,7074,5021,153,7410,3355,476,5500,148327,5602,5465,1387,5295,4886,2773,7253,207,2890,4852,5296	RRAS2,RAP1B,PDE4B,EDNRA,DRD1,MAP2K1,ADCY2,GHRL,NFKB1,ATP1A3,AKT3,ACOX1,EP300,RAP1A,ROCK2,GRIA2,ADORA1,NFKBIA,CHRM1,PRKACB,RAF1,PTGER2,GABBR1,PPP1CC,ATP1A2,CREB1,HHIP,PPP1R1B,FOS,CFTR,HCAR1,ADCY3,CALML5,SOX9,ADRB2,PIK3R3,CAMK2G,RAC2,BAD,PIK3CA,ROCK1,PPP1R12A,ATP2B4,ATP1B1,ATP1B3,JUN,AKT2,GNAI2,HTR1A,PLN,CREB3,TIAM1,OXTR,ADRB1,VAV2,HTR1F,ATP1A1,PPP1CB,CREB3L4,MAPK10,PPARA,CREBBP,PIK3R1,NPY1R,GNAI3,TSHR,AKT1,GRIA1,NPY,PIK3R2
M00146	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex	0.415933955036568	-0.877228793256211	15	6	0.00243605359317905	2463	7161	4697,55967,4698,4694,4695,4706	NDUFA4,NDUFA12,NDUFA5,NDUFA1,NDUFA2,NDUFAB1
hsa_M00146	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex	0.415933955036568	-0.877228793256211	15	6	0.00243605359317905	2463	7161	4698,4697,55967,4694,4706,4695	NDUFA5,NDUFA4,NDUFA12,NDUFA1,NDUFAB1,NDUFA2
ko05030	Cocaine addiction	0.416906155772311	-0.874894128619577	49	18	0.00730816077953715	2463	7161	2891,1020,5567,1812,8851,5173,148327,468,2912,1385,3725,84152,2771,6531,2773,4790,1742,10488	GRIA2,CDK5,PRKACB,DRD1,CDK5R1,PDYN,CREB3L4,ATF4,GRM2,CREB1,JUN,PPP1R1B,GNAI2,SLC6A3,GNAI3,NFKB1,DLG4,CREB3
hsa05030	Cocaine addiction	0.416906155772311	-0.874894128619577	49	18	0.00730816077953715	2463	7161	5173,148327,468,2912,1020,5567,1812,8851,2891,1742,10488,4790,2771,6531,2773,1385,3725,84152	PDYN,CREB3L4,ATF4,GRM2,CDK5,PRKACB,DRD1,CDK5R1,GRIA2,DLG4,CREB3,NFKB1,GNAI2,SLC6A3,GNAI3,CREB1,JUN,PPP1R1B
hsa_M00015	Proline biosynthesis, glutamate => proline	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	5831,29920	PYCR1,PYCR2
hsa_M00288	RPA complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	6118,6119	RPA2,RPA3
M00015	Proline biosynthesis, glutamate => proline	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	29920,5831	PYCR2,PYCR1
hsa_M00133	Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	6723,113451	SRM,AZIN2
hsa_M00390	Exosome, archaea	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	54512,51013	EXOSC4,EXOSC1
hsa_M00425	H/ACA ribonucleoprotein complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	55651,1736	NHP2,DKC1
hsa_M00387	SCF-FBW7 complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	55294,6500	FBXW7,SKP1
M00387	SCF-FBW7 complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	55294,6500	FBXW7,SKP1
M00741	Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	5096,4594	PCCB,MMUT
M00263	DNA polymerase epsilon complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	54107,56655	POLE3,POLE4
M00070	Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	8707,8708	B3GALT2,B3GALT1
M00390	Exosome, archaea	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	54512,51013	EXOSC4,EXOSC1
M00393	TRAMP complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	11044,84186	TENT4A,ZCCHC7
M00133	Polyamine biosynthesis, arginine => agmatine => putrescine => spermidine	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	113451,6723	AZIN2,SRM
M00148	Succinate dehydrogenase (ubiquinone)	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	6390,6391	SDHB,SDHC
M00425	H/ACA ribonucleoprotein complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	1736,55651	DKC1,NHP2
M00286	GINS complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	84296,64785	GINS4,GINS3
hsa_M00261	DNA polymerase alpha / primase complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	5558,23649	PRIM2,POLA2
hsa_M00393	TRAMP complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	11044,84186	TENT4A,ZCCHC7
hsa_M00070	Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	8708,8707	B3GALT1,B3GALT2
M00261	DNA polymerase alpha / primase complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	23649,5558	POLA2,PRIM2
hsa_M00148	Succinate dehydrogenase (ubiquinone)	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	6390,6391	SDHB,SDHC
M00288	RPA complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	6118,6119	RPA2,RPA3
hsa_M00262	DNA polymerase delta complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	5425,57804	POLD2,POLD4
hsa_M00741	Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	5096,4594	PCCB,MMUT
hsa_M00286	GINS complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	64785,84296	GINS3,GINS4
hsa_M00263	DNA polymerase epsilon complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	56655,54107	POLE4,POLE3
M00262	DNA polymerase delta complex	0.426274243608361	-0.852672375501263	4	2	0.000812017864393017	2463	7161	5425,57804	POLD2,POLD4
hsa01210	2-Oxocarboxylic acid metabolism	0.42918982939304	-0.8458559651675	18	7	0.00284206252537556	2463	7161	2875,50,3419,3420,3417,48,3418	GPT,ACO2,IDH3A,IDH3B,IDH1,ACO1,IDH2
ko01210	2-Oxocarboxylic acid metabolism	0.42918982939304	-0.8458559651675	18	7	0.00284206252537556	2463	7161	3420,3417,3418,48,2875,50,3419	IDH3B,IDH1,IDH2,ACO1,GPT,ACO2,IDH3A
hsa04723	Retrograde endocannabinoid signaling	0.432140028933076	-0.839005602211599	101	36	0.0146163215590743	2463	7161	140679,2788,2775,2793,57406,2773,5330,109,2890,59345,2776,2784,51764,23236,2891,2562,5567,5602,2566,2911,2554,108,2555,1268,54331,2791,2771,5579,2782,2785,2787,5578,55970,2561,2790,3760	SLC32A1,GNG7,GNAO1,GNGT2,ABHD6,GNAI3,PLCB2,ADCY3,GRIA1,GNB4,GNAQ,GNB3,GNG13,PLCB1,GRIA2,GABRB3,PRKACB,MAPK10,GABRG2,GRM1,GABRA1,ADCY2,GABRA2,CNR1,GNG2,GNG11,GNAI2,PRKCB,GNB1,GNG3,GNG5,PRKCA,GNG12,GABRB2,GNG10,KCNJ3
ko04723	Retrograde endocannabinoid signaling	0.432140028933076	-0.839005602211599	101	36	0.0146163215590743	2463	7161	2771,2791,54331,108,1268,2555,2785,2782,5579,2561,55970,5578,2787,3760,2790,2773,57406,2793,2775,2788,140679,2776,59345,2890,109,5330,2562,2891,51764,23236,2784,2554,2566,2911,5602,5567	GNAI2,GNG11,GNG2,ADCY2,CNR1,GABRA2,GNG3,GNB1,PRKCB,GABRB2,GNG12,PRKCA,GNG5,KCNJ3,GNG10,GNAI3,ABHD6,GNGT2,GNAO1,GNG7,SLC32A1,GNAQ,GNB4,GRIA1,ADCY3,PLCB2,GABRB3,GRIA2,GNG13,PLCB1,GNB3,GABRA1,GABRG2,GRM1,MAPK10,PRKACB
ko04150	mTOR signaling pathway	0.434032328303	-0.834636258478495	150	53	0.0215184734064149	2463	7161	90423,3479,5290,528,54541,7124,6655,51719,28956,7480,8503,153129,7476,1977,5579,10670,51382,7472,208,523,3551,55004,4040,54468,8322,5296,207,534,5295,3845,5728,1975,6009,5578,10000,8649,9470,201163,5604,9550,3480,6794,55437,5894,220441,3265,8323,83667,1856,7976,10325,6396,2887	ATP6V1E2,IGF1,PIK3CA,ATP6V1C1,DDIT4,TNF,SOS2,CAB39,LAMTOR2,WNT10B,PIK3R3,SLC38A9,WNT7A,EIF4E,PRKCB,RRAGA,ATP6V1D,WNT2,AKT2,ATP6V1A,IKBKB,LAMTOR1,LRP6,MIOS,FZD4,PIK3R2,AKT1,ATP6V1G2,PIK3R1,KRAS,PTEN,EIF4B,RHEB,PRKCA,AKT3,LAMTOR3,EIF4E2,FLCN,MAP2K1,ATP6V1G1,IGF1R,STK11,STRADB,RAF1,RNF152,HRAS,FZD6,SESN2,DVL2,FZD3,RRAGB,SEC13,GRB10
hsa04150	mTOR signaling pathway	0.434032328303	-0.834636258478495	150	53	0.0215184734064149	2463	7161	8322,54468,55004,3551,523,4040,5295,534,5728,3845,5296,207,51719,8503,153129,28956,7480,90423,3479,54541,7124,6655,5290,528,7472,51382,208,1977,7476,10670,5579,3265,8323,83667,1856,220441,6794,3480,55437,9550,5894,6396,2887,7976,10325,1975,6009,5578,201163,5604,10000,8649,9470	FZD4,MIOS,LAMTOR1,IKBKB,ATP6V1A,LRP6,PIK3R1,ATP6V1G2,PTEN,KRAS,PIK3R2,AKT1,CAB39,PIK3R3,SLC38A9,LAMTOR2,WNT10B,ATP6V1E2,IGF1,DDIT4,TNF,SOS2,PIK3CA,ATP6V1C1,WNT2,ATP6V1D,AKT2,EIF4E,WNT7A,RRAGA,PRKCB,HRAS,FZD6,SESN2,DVL2,RNF152,STK11,IGF1R,STRADB,ATP6V1G1,RAF1,SEC13,GRB10,FZD3,RRAGB,EIF4B,RHEB,PRKCA,FLCN,MAP2K1,AKT3,LAMTOR3,EIF4E2
hsa04550	Signaling pathways regulating pluripotency of stem cells	0.44689649779003	-0.805428259748243	139	49	0.0198944376776289	2463	7161	5295,3845,5296,3400,7703,207,3717,4088,10336,658,8322,90,5080,7472,5460,208,4086,7476,8503,7480,4090,659,657,3479,5290,91,4093,7976,130399,84108,3265,8323,1856,3572,4089,3716,3480,5894,9314,1852,3211,6657,5604,1499,10000,4609,3397,2260,4087	PIK3R1,KRAS,PIK3R2,ID4,PCGF2,AKT1,JAK2,SMAD3,PCGF3,BMPR1B,FZD4,ACVR1,PAX6,WNT2,POU5F1,AKT2,SMAD1,WNT7A,PIK3R3,WNT10B,SMAD5,BMPR2,BMPR1A,IGF1,PIK3CA,ACVR1B,SMAD9,FZD3,ACVR1C,PCGF6,HRAS,FZD6,DVL2,IL6ST,SMAD4,JAK1,IGF1R,RAF1,KLF4,DUSP9,HOXB1,SOX2,MAP2K1,CTNNB1,AKT3,MYC,ID1,FGFR1,SMAD2
ko04550	Signaling pathways regulating pluripotency of stem cells	0.44689649779003	-0.805428259748243	139	49	0.0198944376776289	2463	7161	91,7976,4093,3265,84108,8323,1856,3572,4089,130399,5894,9314,1852,3480,3716,5604,1499,3211,6657,4609,3397,10000,2260,4087,3845,5295,3400,7703,207,4088,3717,5296,8322,90,10336,658,5080,5460,208,7472,4086,7476,8503,7480,4090,5290,659,657,3479	ACVR1B,FZD3,SMAD9,HRAS,PCGF6,FZD6,DVL2,IL6ST,SMAD4,ACVR1C,RAF1,KLF4,DUSP9,IGF1R,JAK1,MAP2K1,CTNNB1,HOXB1,SOX2,MYC,ID1,AKT3,FGFR1,SMAD2,KRAS,PIK3R1,ID4,PCGF2,AKT1,SMAD3,JAK2,PIK3R2,FZD4,ACVR1,PCGF3,BMPR1B,PAX6,POU5F1,AKT2,WNT2,SMAD1,WNT7A,PIK3R3,WNT10B,SMAD5,PIK3CA,BMPR2,BMPR1A,IGF1
ko04072	Phospholipase D signaling pathway	0.452421303290711	-0.793141446346835	145	51	0.0207064555420219	2463	7161	109,6850,56848,53358,9266,382,553,3576,5894,2911,5899,3265,100137049,55326,10000,108,375,5604,5294,9170,6009,5578,22800,10554,10161,22808,5330,5898,207,1902,3577,5296,3845,5737,5295,5781,2918,2549,9267,23236,6464,8394,1785,208,3815,5290,6655,27128,2912,8503,2207	ADCY3,SYK,SPHK2,SHC3,CYTH2,ARF6,AVPR1B,CXCL8,RAF1,GRM1,RALB,HRAS,PLA2G4B,AGPAT5,AKT3,ADCY2,ARF1,MAP2K1,PIK3CG,LPAR2,RHEB,PRKCA,RRAS2,AGPAT1,LPAR6,MRAS,PLCB2,RALA,AKT1,LPAR1,CXCR1,PIK3R2,KRAS,PTGFR,PIK3R1,PTPN11,GRM8,GAB1,CYTH1,PLCB1,SHC1,PIP5K1A,DNM2,AKT2,KIT,PIK3CA,SOS2,CYTH4,GRM2,PIK3R3,FCER1G
hsa04072	Phospholipase D signaling pathway	0.452421303290711	-0.793141446346835	145	51	0.0207064555420219	2463	7161	5330,5898,207,1902,3577,5296,3845,5737,5295,5781,2918,2549,9267,23236,6464,8394,1785,208,3815,5290,6655,2912,27128,8503,2207,109,6850,53358,56848,9266,382,553,3576,5894,2911,5899,3265,100137049,55326,10000,108,375,5604,5294,9170,6009,5578,22800,10554,22808,10161	PLCB2,RALA,AKT1,LPAR1,CXCR1,PIK3R2,KRAS,PTGFR,PIK3R1,PTPN11,GRM8,GAB1,CYTH1,PLCB1,SHC1,PIP5K1A,DNM2,AKT2,KIT,PIK3CA,SOS2,GRM2,CYTH4,PIK3R3,FCER1G,ADCY3,SYK,SHC3,SPHK2,CYTH2,ARF6,AVPR1B,CXCL8,RAF1,GRM1,RALB,HRAS,PLA2G4B,AGPAT5,AKT3,ADCY2,ARF1,MAP2K1,PIK3CG,LPAR2,RHEB,PRKCA,RRAS2,AGPAT1,MRAS,LPAR6
hsa_M00092	Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE	0.453811258092522	-0.790073898454651	7	3	0.00121802679658952	2463	7161	85465,55224,1120	SELENOI,ETNK2,CHKB
M00007	Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P	0.453811258092522	-0.790073898454651	7	3	0.00121802679658952	2463	7161	22934,6120,8277	RPIA,RPE,TKTL1
M00092	Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE	0.453811258092522	-0.790073898454651	7	3	0.00121802679658952	2463	7161	85465,55224,1120	SELENOI,ETNK2,CHKB
hsa_M00007	Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P	0.453811258092522	-0.790073898454651	7	3	0.00121802679658952	2463	7161	6120,22934,8277	RPE,RPIA,TKTL1
hsa04640	Hematopoietic cell lineage	0.45427578223476	-0.789050815507472	96	34	0.0138043036946813	2463	7161	1437,3655,929,947,3565,3559,909,3562,4311,911,7850,913,3567,2209,917,1791,3815,910,912,952,3673,3574,948,928,914,3553,3552,920,3569,7037,966,2056,2815,7124	CSF2,ITGA6,CD14,CD34,IL4,IL2RA,CD1A,IL3,MME,CD1C,IL1R2,CD1E,IL5,FCGR1A,CD3G,DNTT,KIT,CD1B,CD1D,CD38,ITGA2,IL7,CD36,CD9,CD2,IL1B,IL1A,CD4,IL6,TFRC,CD59,EPO,GP9,TNF
ko04640	Hematopoietic cell lineage	0.45427578223476	-0.789050815507472	96	34	0.0138043036946813	2463	7161	914,3553,3552,966,920,7037,3569,7124,2815,2056,3815,910,1791,952,912,3673,3574,928,948,913,3567,911,7850,4311,2209,917,1437,3655,929,947,3559,3562,909,3565	CD2,IL1B,IL1A,CD59,CD4,TFRC,IL6,TNF,GP9,EPO,KIT,CD1B,DNTT,CD38,CD1D,ITGA2,IL7,CD9,CD36,CD1E,IL5,CD1C,IL1R2,MME,FCGR1A,CD3G,CSF2,ITGA6,CD14,CD34,IL2RA,IL3,CD1A,IL4
ko00601	Glycosphingolipid biosynthesis - lacto and neolacto series	0.457197582739091	-0.78263963417281	27	10	0.00406008932196508	2463	7161	10690,8706,2523,8707,6484,8708,8703,8702,2683,10678	FUT9,B3GALNT1,FUT1,B3GALT2,ST3GAL4,B3GALT1,B4GALT3,B4GALT4,B4GALT1,B3GNT2
hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	0.457197582739091	-0.78263963417281	27	10	0.00406008932196508	2463	7161	8708,6484,2523,8707,8706,10690,10678,2683,8702,8703	B3GALT1,ST3GAL4,FUT1,B3GALT2,B3GALNT1,FUT9,B3GNT2,B4GALT1,B4GALT4,B4GALT3
hsa05034	Alcoholism	0.459591047517252	-0.777418212054405	180	63	0.02557856272838	2463	7161	2791,54331,2771,221613,10488,2030,4915,2787,85236,158983,6655,474382,8841,3845,8331,2793,2773,4852,255626,3015,2784,6464,8334,148327,5500,5173,5604,9555,94239,8329,8335,2782,8348,2785,5569,3014,55970,1812,2790,8350,2788,8342,84152,10014,53358,1385,8345,5501,92815,2775,6531,59345,55506,10013,3013,8970,51806,55766,3265,51764,5894,468,79885	GNG11,GNG2,GNAI2,H2AC1,CREB3,SLC29A1,NTRK2,GNG5,H2BC12,H2BW1,SOS2,H2AB1,HDAC3,KRAS,H2AC14,GNGT2,GNAI3,NPY,H2BC1,H2AZ1,GNB3,SHC1,H2AC6,CREB3L4,PPP1CB,PDYN,MAP2K1,MACROH2A1,H2AZ2,H2AC13,H2AC4,GNB1,H2BC17,GNG3,PKIA,H2AX,GNG12,DRD1,GNG10,H3C1,GNG7,H2BC14,PPP1R1B,HDAC5,SHC3,CREB1,H2BC9,PPP1CC,H2AC25,GNAO1,SLC6A3,GNB4,MACROH2A2,HDAC6,H2AC7,H2BC11,CALML5,H2AJ,HRAS,GNG13,RAF1,ATF4,HDAC11
ko05034	Alcoholism	0.459591047517252	-0.777418212054405	180	63	0.02557856272838	2463	7161	10013,59345,55506,8970,51806,3013,1385,53358,8345,5501,2788,84152,8342,10014,6531,92815,2775,5894,468,79885,3265,55766,51764,2785,8348,2782,5604,9555,8329,8335,94239,8350,2790,1812,5569,3014,55970,4852,255626,3015,3845,2773,8331,2793,8334,5500,5173,148327,2784,6464,4915,221613,2030,10488,2771,2791,54331,6655,474382,8841,85236,2787,158983	HDAC6,GNB4,MACROH2A2,H2BC11,CALML5,H2AC7,CREB1,SHC3,H2BC9,PPP1CC,GNG7,PPP1R1B,H2BC14,HDAC5,SLC6A3,H2AC25,GNAO1,RAF1,ATF4,HDAC11,HRAS,H2AJ,GNG13,GNG3,H2BC17,GNB1,MAP2K1,MACROH2A1,H2AC13,H2AC4,H2AZ2,H3C1,GNG10,DRD1,PKIA,H2AX,GNG12,NPY,H2BC1,H2AZ1,KRAS,GNAI3,H2AC14,GNGT2,H2AC6,PPP1CB,PDYN,CREB3L4,GNB3,SHC1,NTRK2,H2AC1,SLC29A1,CREB3,GNAI2,GNG11,GNG2,SOS2,H2AB1,HDAC3,H2BC12,GNG5,H2BW1
hsa_M00693	Cell cycle - G2/M transition	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	891,890,494551,983	CCNB1,CCNA2,WEE2,CDK1
ko00920	Sulfur metabolism	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	9060,54928,4357,7263	PAPSS2,BPNT2,MPST,TST
M00693	Cell cycle - G2/M transition	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	494551,983,891,890	WEE2,CDK1,CCNB1,CCNA2
hsa00920	Sulfur metabolism	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	7263,54928,9060,4357	TST,BPNT2,PAPSS2,MPST
M00391	Exosome, eukaryotes	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	11340,54512,51013,51010	EXOSC8,EXOSC4,EXOSC1,EXOSC3
hsa_M00391	Exosome, eukaryotes	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	51010,54512,51013,11340	EXOSC3,EXOSC4,EXOSC1,EXOSC8
M00681	Activin signaling	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	4089,91,4088,4087	SMAD4,ACVR1B,SMAD3,SMAD2
hsa_M00681	Activin signaling	0.469719295365971	-0.755620006601406	10	4	0.00162403572878603	2463	7161	4089,4088,91,4087	SMAD4,SMAD3,ACVR1B,SMAD2
hsa04213	Longevity regulating pathway - multiple species	0.475754855048331	-0.742852567816791	62	22	0.00893219650832318	2463	7161	5567,3480,6648,3265,109,207,81570,5296,3845,1979,5295,5564,3312,5290,3479,5571,8503,10000,208,6647,108,1410	PRKACB,IGF1R,SOD2,HRAS,ADCY3,AKT1,CLPB,PIK3R2,KRAS,EIF4EBP2,PIK3R1,PRKAB1,HSPA8,PIK3CA,IGF1,PRKAG1,PIK3R3,AKT3,AKT2,SOD1,ADCY2,CRYAB
ko04213	Longevity regulating pathway - multiple species	0.475754855048331	-0.742852567816791	62	22	0.00893219650832318	2463	7161	5567,5290,3312,5564,3480,5571,3479,8503,3265,6648,207,109,5296,81570,10000,3845,108,6647,208,1410,5295,1979	PRKACB,PIK3CA,HSPA8,PRKAB1,IGF1R,PRKAG1,IGF1,PIK3R3,HRAS,SOD2,AKT1,ADCY3,PIK3R2,CLPB,AKT3,KRAS,ADCY2,SOD1,AKT2,CRYAB,PIK3R1,EIF4EBP2
hsa_M00692	Cell cycle - G1/S transition	0.480854029176829	-0.732191528578666	13	5	0.00203004466098254	2463	7161	1019,896,1021,5925,595	CDK4,CCND3,CDK6,RB1,CCND1
hsa_M00050	Guanine ribonucleotide biosynthesis IMP => GDP,GTP	0.480854029176829	-0.732191528578666	13	5	0.00203004466098254	2463	7161	2987,4830,4833,8833,4831	GUK1,NME1,NME4,GMPS,NME2
M00050	Guanine ribonucleotide biosynthesis IMP => GDP,GTP	0.480854029176829	-0.732191528578666	13	5	0.00203004466098254	2463	7161	4833,8833,4831,2987,4830	NME4,GMPS,NME2,GUK1,NME1
M00692	Cell cycle - G1/S transition	0.480854029176829	-0.732191528578666	13	5	0.00203004466098254	2463	7161	896,1019,1021,595,5925	CCND3,CDK4,CDK6,CCND1,RB1
ko04910	Insulin signaling pathway	0.493822880021381	-0.705578368552774	138	48	0.0194884287454324	2463	7161	5571,5290,6655,572,8503,1977,2203,5255,5106,867,208,5602,1399,3551,5500,6464,5296,207,9021,5295,3845,5507,5564,122809,8835,5837,5257,6009,2997,92579,10000,10211,9470,3636,5770,2002,5260,5604,51763,31,8789,5567,5894,5834,3265,51806,5501,53358	PRKAG1,PIK3CA,SOS2,BAD,PIK3R3,EIF4E,FBP1,PHKA1,PCK2,CBL,AKT2,MAPK10,CRKL,IKBKB,PPP1CB,SHC1,PIK3R2,AKT1,SOCS3,PIK3R1,KRAS,PPP1R3C,PRKAB1,SOCS4,SOCS2,PYGM,PHKB,RHEB,GYS1,G6PC3,AKT3,FLOT1,EIF4E2,INPPL1,PTPN1,ELK1,PHKG1,MAP2K1,INPP5K,ACACA,FBP2,PRKACB,RAF1,PYGB,HRAS,CALML5,PPP1CC,SHC3
hsa04910	Insulin signaling pathway	0.493822880021381	-0.705578368552774	138	48	0.0194884287454324	2463	7161	6464,1399,5602,3551,5500,3845,9021,5295,207,5296,8503,5290,572,6655,5571,208,867,2203,5106,5255,1977,3265,5834,8789,5894,5567,31,51763,53358,5501,51806,6009,5837,5257,5564,8835,122809,5507,5260,2002,5604,10211,5770,9470,3636,10000,92579,2997	SHC1,CRKL,MAPK10,IKBKB,PPP1CB,KRAS,SOCS3,PIK3R1,AKT1,PIK3R2,PIK3R3,PIK3CA,BAD,SOS2,PRKAG1,AKT2,CBL,FBP1,PCK2,PHKA1,EIF4E,HRAS,PYGB,FBP2,RAF1,PRKACB,ACACA,INPP5K,SHC3,PPP1CC,CALML5,RHEB,PYGM,PHKB,PRKAB1,SOCS2,SOCS4,PPP1R3C,PHKG1,ELK1,MAP2K1,FLOT1,PTPN1,EIF4E2,INPPL1,AKT3,G6PC3,GYS1
ko04320	Dorso-ventral axis formation	0.512347137750122	-0.668752880264902	28	10	0.00406008932196508	2463	7161	4853,6655,2120,143689,440822,3845,5604,55124,9271,64506	NOTCH2,SOS2,ETV6,PIWIL4,PIWIL3,KRAS,MAP2K1,PIWIL2,PIWIL1,CPEB1
hsa04320	Dorso-ventral axis formation	0.512347137750122	-0.668752880264902	28	10	0.00406008932196508	2463	7161	440822,143689,4853,2120,6655,64506,9271,5604,3845,55124	PIWIL3,PIWIL4,NOTCH2,ETV6,SOS2,CPEB1,PIWIL1,MAP2K1,KRAS,PIWIL2
ko04721	Synaptic vesicle cycle	0.512428196634534	-0.668594681912812	63	22	0.00893219650832318	2463	7161	10815,1173,1175,6844,534,8775,5864,140679,523,6812,9550,160,10814,6804,6616,1785,51382,533,90423,594855,528,8992	CPLX1,AP2M1,AP2S1,VAMP2,ATP6V1G2,NAPA,RAB3A,SLC32A1,ATP6V1A,STXBP1,ATP6V1G1,AP2A1,CPLX2,STX1A,SNAP25,DNM2,ATP6V1D,ATP6V0B,ATP6V1E2,CPLX3,ATP6V1C1,ATP6V0E1
hsa04721	Synaptic vesicle cycle	0.512428196634534	-0.668594681912812	63	22	0.00893219650832318	2463	7161	5864,140679,6844,534,8775,10815,1173,1175,6804,6616,10814,160,9550,523,6812,533,51382,1785,8992,594855,528,90423	RAB3A,SLC32A1,VAMP2,ATP6V1G2,NAPA,CPLX1,AP2M1,AP2S1,STX1A,SNAP25,CPLX2,AP2A1,ATP6V1G1,ATP6V1A,STXBP1,ATP6V0B,ATP6V1D,DNM2,ATP6V0E1,CPLX3,ATP6V1C1,ATP6V1E2
hsa04971	Gastric acid secretion	0.523831291085768	-0.646585610079274	75	26	0.0105562322371092	2463	7161	481,483,5578,6750,818,3274,60,478,54207,5579,760,1131,108,2771,476,5567,23236,109,5330,1080,3766,2776,51806,3759,477,2773	ATP1B1,ATP1B3,PRKCA,SST,CAMK2G,HRH2,ACTB,ATP1A3,KCNK10,PRKCB,CA2,CHRM3,ADCY2,GNAI2,ATP1A1,PRKACB,PLCB1,ADCY3,PLCB2,CFTR,KCNJ10,GNAQ,CALML5,KCNJ2,ATP1A2,GNAI3
ko04971	Gastric acid secretion	0.523831291085768	-0.646585610079274	75	26	0.0105562322371092	2463	7161	60,3274,818,5578,6750,481,483,2771,1131,108,760,5579,54207,478,23236,5567,476,2773,477,3759,51806,2776,3766,1080,5330,109	ACTB,HRH2,CAMK2G,PRKCA,SST,ATP1B1,ATP1B3,GNAI2,CHRM3,ADCY2,CA2,PRKCB,KCNK10,ATP1A3,PLCB1,PRKACB,ATP1A1,GNAI3,ATP1A2,KCNJ2,CALML5,GNAQ,KCNJ10,CFTR,PLCB2,ADCY3
hsa04015	Rap1 signaling pathway	0.539927287524333	-0.616320801223027	210	72	0.0292326431181486	2463	7161	8503,5880,5608,2246,2255,2252,5290,50855,3479,7424,208,1268,8074,1944,3815,2771,26037,9771,5579,7074,2248,25780,5606,7410,2258,23236,1399,27006,3845,2773,5295,207,5898,284,5330,5296,998,8822,1902,5578,5908,2260,9170,60,22808,3937,10235,1499,5604,889,108,2257,3397,10000,1946,3265,6714,5899,5906,23683,5894,5028,7422,3480,1969,2775,109,4233,8823,51806,1500,2776	PIK3R3,RAC2,MAP2K6,FGF1,FGF10,FGF7,PIK3CA,PARD6A,IGF1,VEGFC,AKT2,CNR1,FGF23,EFNA3,KIT,GNAI2,SIPA1L1,RAPGEF5,PRKCB,TIAM1,FGF3,RASGRP3,MAP2K3,VAV2,FGF13,PLCB1,CRKL,FGF22,KRAS,GNAI3,PIK3R1,AKT1,RALA,ANGPT1,PLCB2,PIK3R2,CDC42,FGF17,LPAR1,PRKCA,RAP1B,FGFR1,LPAR2,ACTB,MRAS,LCP2,RASGRP2,CTNNB1,MAP2K1,KRIT1,ADCY2,FGF12,ID1,AKT3,EFNA5,HRAS,SRC,RALB,RAP1A,PRKD3,RAF1,P2RY1,VEGFA,IGF1R,EPHA2,GNAO1,ADCY3,MET,FGF16,CALML5,CTNND1,GNAQ
ko04015	Rap1 signaling pathway	0.539927287524333	-0.616320801223027	210	72	0.0292326431181486	2463	7161	5579,26037,9771,1944,3815,2771,208,7424,1268,8074,3479,50855,5290,2252,2255,2246,5880,5608,8503,1902,5296,998,8822,5898,5330,284,207,2773,5295,27006,3845,1399,7410,2258,23236,5606,2248,25780,7074,10000,3397,2257,889,108,1499,5604,3937,10235,22808,60,5908,5578,9170,2260,2776,8823,1500,51806,109,4233,2775,1969,7422,3480,5028,5894,5906,23683,5899,1946,3265,6714	PRKCB,SIPA1L1,RAPGEF5,EFNA3,KIT,GNAI2,AKT2,VEGFC,CNR1,FGF23,IGF1,PARD6A,PIK3CA,FGF7,FGF10,FGF1,RAC2,MAP2K6,PIK3R3,LPAR1,PIK3R2,CDC42,FGF17,RALA,PLCB2,ANGPT1,AKT1,GNAI3,PIK3R1,FGF22,KRAS,CRKL,VAV2,FGF13,PLCB1,MAP2K3,FGF3,RASGRP3,TIAM1,AKT3,ID1,FGF12,KRIT1,ADCY2,CTNNB1,MAP2K1,LCP2,RASGRP2,MRAS,ACTB,RAP1B,PRKCA,LPAR2,FGFR1,GNAQ,FGF16,CTNND1,CALML5,ADCY3,MET,GNAO1,EPHA2,VEGFA,IGF1R,P2RY1,RAF1,RAP1A,PRKD3,RALB,EFNA5,HRAS,SRC
hsa04713	Circadian entrainment	0.540325689170232	-0.615583193139444	96	33	0.0133982947624848	2463	7161	2790,3760,9722,2787,818,5578,55970,5579,2782,2785,108,54331,2791,2771,2983,5567,51655,2784,23236,51764,2891,5330,109,59345,2890,2776,51806,2788,1385,2353,2775,2793,2773	GNG10,KCNJ3,NOS1AP,GNG5,CAMK2G,PRKCA,GNG12,PRKCB,GNB1,GNG3,ADCY2,GNG2,GNG11,GNAI2,GUCY1B1,PRKACB,RASD1,GNB3,PLCB1,GNG13,GRIA2,PLCB2,ADCY3,GNB4,GRIA1,GNAQ,CALML5,GNG7,CREB1,FOS,GNAO1,GNGT2,GNAI3
ko04713	Circadian entrainment	0.540325689170232	-0.615583193139444	96	33	0.0133982947624848	2463	7161	9722,3760,2790,55970,5578,818,2787,2785,2782,5579,2771,2791,54331,108,51655,5567,2983,2891,23236,51764,2784,51806,2776,59345,109,2890,5330,2773,2353,2793,2775,1385,2788	NOS1AP,KCNJ3,GNG10,GNG12,PRKCA,CAMK2G,GNG5,GNG3,GNB1,PRKCB,GNAI2,GNG11,GNG2,ADCY2,RASD1,PRKACB,GUCY1B1,GRIA2,PLCB1,GNG13,GNB3,CALML5,GNAQ,GNB4,ADCY3,GRIA1,PLCB2,GNAI3,FOS,GNGT2,GNAO1,CREB1,GNG7
hsa05131	Shigellosis	0.548520282809718	-0.600531021263732	64	22	0.00893219650832318	2463	7161	1399,5602,3551,3059,3576,10094,4793,4792,9475,6714,2017,998,23291,10459,6093,8976,391,60,4790,63916,10109,9844	CRKL,MAPK10,IKBKB,HCLS1,CXCL8,ARPC3,NFKBIB,NFKBIA,ROCK2,SRC,CTTN,CDC42,FBXW11,MAD2L2,ROCK1,WASL,RHOG,ACTB,NFKB1,ELMO2,ARPC2,ELMO1
hsa_M00034	Methionine salvage pathway	0.557632911323936	-0.584054398099831	11	4	0.00162403572878603	2463	7161	27430,4507,6723,4144	MAT2B,MTAP,SRM,MAT2A
M00034	Methionine salvage pathway	0.557632911323936	-0.584054398099831	11	4	0.00162403572878603	2463	7161	6723,4144,27430,4507	SRM,MAT2A,MAT2B,MTAP
hsa00430	Taurine and hypotaurine metabolism	0.557632911323936	-0.584054398099831	11	4	0.00162403572878603	2463	7161	1036,84890,2686,2572	CDO1,ADO,GGT7,GAD2
hsa_M00101	Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol	0.557632911323936	-0.584054398099831	11	4	0.00162403572878603	2463	7161	10826,50814,6307,6309	FAXDC2,NSDHL,MSMO1,SC5D
ko00430	Taurine and hypotaurine metabolism	0.557632911323936	-0.584054398099831	11	4	0.00162403572878603	2463	7161	84890,1036,2686,2572	ADO,CDO1,GGT7,GAD2
M00101	Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol	0.557632911323936	-0.584054398099831	11	4	0.00162403572878603	2463	7161	10826,6309,50814,6307	FAXDC2,SC5D,NSDHL,MSMO1
M00428	eIF4F complex	0.557715442108888	-0.583906407053181	8	3	0.00121802679658952	2463	7161	9470,1977,1974	EIF4E2,EIF4E,EIF4A2
hsa_M00428	eIF4F complex	0.557715442108888	-0.583906407053181	8	3	0.00121802679658952	2463	7161	9470,1974,1977	EIF4E2,EIF4A2,EIF4E
ko00120	Primary bile acid biosynthesis	0.559605660829581	-0.580522920392117	17	6	0.00243605359317905	2463	7161	9023,51302,23600,1581,1593,10005	CH25H,CYP39A1,AMACR,CYP7A1,CYP27A1,ACOT8
hsa00120	Primary bile acid biosynthesis	0.559605660829581	-0.580522920392117	17	6	0.00243605359317905	2463	7161	23600,9023,51302,10005,1581,1593	AMACR,CH25H,CYP39A1,ACOT8,CYP7A1,CYP27A1
M00383	ECV complex	0.559937594003711	-0.579929940741848	5	2	0.000812017864393017	2463	7161	8453,6921	CUL2,ELOC
M00380	SCF-BTRC complex	0.559937594003711	-0.579929940741848	5	2	0.000812017864393017	2463	7161	23291,6500	FBXW11,SKP1
hsa_M00383	ECV complex	0.559937594003711	-0.579929940741848	5	2	0.000812017864393017	2463	7161	6921,8453	ELOC,CUL2
hsa_M00380	SCF-BTRC complex	0.559937594003711	-0.579929940741848	5	2	0.000812017864393017	2463	7161	23291,6500	FBXW11,SKP1
M00079	Keratan sulfate degradation	0.559937594003711	-0.579929940741848	5	2	0.000812017864393017	2463	7161	3073,3074	HEXA,HEXB
hsa_M00079	Keratan sulfate degradation	0.559937594003711	-0.579929940741848	5	2	0.000812017864393017	2463	7161	3074,3073	HEXB,HEXA
hsa04911	Insulin secretion	0.562514862356529	-0.575337723285453	85	29	0.0117742590336987	2463	7161	3767,148327,468,476,5567,23236,6616,6804,2776,5330,109,6844,2767,10242,5864,477,1385,483,481,3778,818,5578,10488,3779,5579,478,6513,108,1131	KCNJ11,CREB3L4,ATF4,ATP1A1,PRKACB,PLCB1,SNAP25,STX1A,GNAQ,PLCB2,ADCY3,VAMP2,GNA11,KCNMB2,RAB3A,ATP1A2,CREB1,ATP1B3,ATP1B1,KCNMA1,CAMK2G,PRKCA,CREB3,KCNMB1,PRKCB,ATP1A3,SLC2A1,ADCY2,CHRM3
ko04614	Renin-angiotensin system	0.562515410011184	-0.575336749703376	23	8	0.00324807145757207	2463	7161	5972,4311,1215,2028,5547,10159,5550,5476	REN,MME,CMA1,ENPEP,PRCP,ATP6AP2,PREP,CTSA
hsa04614	Renin-angiotensin system	0.562515410011184	-0.575336749703376	23	8	0.00324807145757207	2463	7161	4311,5972,5550,5476,5547,2028,1215,10159	MME,REN,PREP,CTSA,PRCP,ENPEP,CMA1,ATP6AP2
hsa_M00068	Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	8706	B3GALNT1
hsa_M00399	Cap binding complex	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	22916	NCBP2
hsa_M00067	Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	9514	GAL3ST1
M00293	DNA polymerase zeta  complex	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	10459	MAD2L2
M00068	Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	8706	B3GALNT1
M00151	Cytochrome bc1 complex respiratory unit	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	1537	CYC1
M00399	Cap binding complex	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	22916	NCBP2
M00067	Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	9514	GAL3ST1
hsa_M00151	Cytochrome bc1 complex respiratory unit	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	1537	CYC1
hsa_M00293	DNA polymerase zeta  complex	0.569625157674697	-0.562776752593746	2	1	0.000406008932196508	2463	7161	10459	MAD2L2
hsa00830	Retinol metabolism	0.583762373977031	-0.538261272832632	65	22	0.00893219650832318	2463	7161	124,54658,125,1543,51109,79799,9227,9249,728635,10901,1558,1592,8228,195814,54884,8630,157506,145226,316,1577,1562,1559	ADH1A,UGT1A1,ADH1B,CYP1A1,RDH11,UGT2A3,LRAT,DHRS3,DHRS4L1,DHRS4,CYP2C8,CYP26A1,PNPLA4,SDR16C5,RETSAT,HSD17B6,RDH10,RDH12,AOX1,CYP3A5,CYP2C18,CYP2C9
ko00830	Retinol metabolism	0.583762373977031	-0.538261272832632	65	22	0.00893219650832318	2463	7161	125,10901,1558,1592,54658,124,728635,9249,51109,1543,157506,8630,195814,54884,8228,316,79799,145226,1559,1562,1577,9227	ADH1B,DHRS4,CYP2C8,CYP26A1,UGT1A1,ADH1A,DHRS4L1,DHRS3,RDH11,CYP1A1,RDH10,HSD17B6,SDR16C5,RETSAT,PNPLA4,AOX1,UGT2A3,RDH12,CYP2C9,CYP2C18,CYP3A5,LRAT
hsa01230	Biosynthesis of amino acids	0.587834481146095	-0.531309865360064	74	25	0.0101502233049127	2463	7161	29920,50,6470,3420,5631,5831,8277,4144,22934,384,2597,27430,3417,2023,10993,2026,5091,6120,2752,48,3418,2875,5230,3419,5223	PYCR2,ACO2,SHMT1,IDH3B,PRPS1,PYCR1,TKTL1,MAT2A,RPIA,ARG2,GAPDH,MAT2B,IDH1,ENO1,SDS,ENO2,PC,RPE,GLUL,ACO1,IDH2,GPT,PGK1,IDH3A,PGAM1
ko01230	Biosynthesis of amino acids	0.587834481146095	-0.531309865360064	74	25	0.0101502233049127	2463	7161	2752,48,3418,5091,2026,6120,10993,2023,5223,3419,5230,2875,5831,8277,4144,6470,5631,3420,29920,50,3417,27430,2597,22934,384	GLUL,ACO1,IDH2,PC,ENO2,RPE,SDS,ENO1,PGAM1,IDH3A,PGK1,GPT,PYCR1,TKTL1,MAT2A,SHMT1,PRPS1,IDH3B,PYCR2,ACO2,IDH1,MAT2B,GAPDH,RPIA,ARG2
hsa04912	GnRH signaling pathway	0.595500846761381	-0.518352468254324	92	31	0.0125862768980918	2463	7161	6655,5578,5608,818,3972,5579,5604,108,3725,2002,468,5602,5894,5567,2797,5606,23236,100137049,6714,3265,998,2796,51806,1839,2776,4215,109,5330,4323,3845,2767	SOS2,PRKCA,MAP2K6,CAMK2G,LHB,PRKCB,MAP2K1,ADCY2,JUN,ELK1,ATF4,MAPK10,RAF1,PRKACB,GNRH2,MAP2K3,PLCB1,PLA2G4B,SRC,HRAS,CDC42,GNRH1,CALML5,HBEGF,GNAQ,MAP3K3,ADCY3,PLCB2,MMP14,KRAS,GNA11
ko04912	GnRH signaling pathway	0.595500846761381	-0.518352468254324	92	31	0.0125862768980918	2463	7161	4323,3845,2767,4215,5330,109,51806,2796,998,2776,1839,6714,3265,5606,100137049,23236,5567,5894,2797,5602,468,5604,3725,108,2002,5579,3972,818,5608,5578,6655	MMP14,KRAS,GNA11,MAP3K3,PLCB2,ADCY3,CALML5,GNRH1,CDC42,GNAQ,HBEGF,SRC,HRAS,MAP2K3,PLA2G4B,PLCB1,PRKACB,RAF1,GNRH2,MAPK10,ATF4,MAP2K1,JUN,ADCY2,ELK1,PRKCB,LHB,CAMK2G,MAP2K6,PRKCA,SOS2
hsa04658	Th1 and Th2 cell differentiation	0.595500846761381	-0.518352468254324	92	31	0.0125862768980918	2463	7161	3560,920,6772,3725,5530,3561,6776,4790,3567,3516,4792,4793,3593,3558,3592,3459,5535,3716,3551,5602,919,5588,3596,917,2353,6778,3559,3458,3565,4853,3717	IL2RB,CD4,STAT1,JUN,PPP3CA,IL2RG,STAT5A,NFKB1,IL5,RBPJ,NFKBIA,NFKBIB,IL12B,IL2,IL12A,IFNGR1,PPP3R2,JAK1,IKBKB,MAPK10,CD247,PRKCQ,IL13,CD3G,FOS,STAT6,IL2RA,IFNG,IL4,NOTCH2,JAK2
ko04658	Th1 and Th2 cell differentiation	0.595500846761381	-0.518352468254324	92	31	0.0125862768980918	2463	7161	3717,4853,3565,3458,3559,6778,2353,917,3596,5588,919,5602,3551,3716,5535,3459,3593,3558,3592,4792,3516,4793,3567,4790,6776,3561,5530,3725,6772,920,3560	JAK2,NOTCH2,IL4,IFNG,IL2RA,STAT6,FOS,CD3G,IL13,PRKCQ,CD247,MAPK10,IKBKB,JAK1,PPP3R2,IFNGR1,IL12B,IL2,IL12A,NFKBIA,RBPJ,NFKBIB,IL5,NFKB1,STAT5A,IL2RG,PPP3CA,JUN,STAT1,CD4,IL2RB
ko00620	Pyruvate metabolism	0.614953405764049	-0.486208777031065	39	13	0.00527811611855461	2463	7161	5091,5106,38,3945,5162,4190,31,2739,55902,5160,92483,1737,3939	PC,PCK2,ACAT1,LDHB,PDHB,MDH1,ACACA,GLO1,ACSS2,PDHA1,LDHAL6B,DLAT,LDHA
hsa00620	Pyruvate metabolism	0.614953405764049	-0.486208777031065	39	13	0.00527811611855461	2463	7161	3945,38,5162,4190,5091,5106,3939,1737,31,2739,55902,92483,5160	LDHB,ACAT1,PDHB,MDH1,PC,PCK2,LDHA,DLAT,ACACA,GLO1,ACSS2,LDHAL6B,PDHA1
hsa00051	Fructose and mannose metabolism	0.615648428721338	-0.485079210973692	33	11	0.00446609825416159	2463	7161	29925,2203,7264,5373,6652,8790,8789,2762,231,29926,5208	GMPPB,FBP1,GFUS,PMM2,SORD,FPGT,FBP2,GMDS,AKR1B1,GMPPA,PFKFB2
ko00051	Fructose and mannose metabolism	0.615648428721338	-0.485079210973692	33	11	0.00446609825416159	2463	7161	7264,231,5208,29926,8789,2203,8790,6652,29925,5373,2762	GFUS,AKR1B1,PFKFB2,GMPPA,FBP2,FBP1,FPGT,SORD,GMPPB,PMM2,GMDS
hsa05310	Asthma	0.616396715429317	-0.483864504185486	30	10	0.00406008932196508	2463	7161	958,3586,3567,2207,7124,3562,6356,3596,3565,959	CD40,IL10,IL5,FCER1G,TNF,IL3,CCL11,IL13,IL4,CD40LG
ko05310	Asthma	0.616396715429317	-0.483864504185486	30	10	0.00406008932196508	2463	7161	3586,958,3567,2207,3562,6356,7124,959,3596,3565	IL10,CD40,IL5,FCER1G,IL3,CCL11,TNF,CD40LG,IL13,IL4
hsa_M00160	V-type ATPase, eukaryotes	0.61915356377932	-0.479401953415249	24	8	0.00324807145757207	2463	7161	533,8992,534,51382,528,9550,523,90423	ATP6V0B,ATP6V0E1,ATP6V1G2,ATP6V1D,ATP6V1C1,ATP6V1G1,ATP6V1A,ATP6V1E2
hsa04977	Vitamin digestion and absorption	0.61915356377932	-0.479401953415249	24	8	0.00324807145757207	2463	7161	55788,5948,9227,25974,80704,8884,113278,10560	LMBRD1,RBP2,LRAT,MMACHC,SLC19A3,SLC5A6,SLC52A3,SLC19A2
ko04977	Vitamin digestion and absorption	0.61915356377932	-0.479401953415249	24	8	0.00324807145757207	2463	7161	113278,10560,55788,5948,9227,25974,80704,8884	SLC52A3,SLC19A2,LMBRD1,RBP2,LRAT,MMACHC,SLC19A3,SLC5A6
M00160	V-type ATPase, eukaryotes	0.61915356377932	-0.479401953415249	24	8	0.00324807145757207	2463	7161	528,9550,523,90423,533,8992,51382,534	ATP6V1C1,ATP6V1G1,ATP6V1A,ATP6V1E2,ATP6V0B,ATP6V0E1,ATP6V1D,ATP6V1G2
M00049	Adenine ribonucleotide biosynthesis, IMP => ADP,ATP	0.621482884050684	-0.475646908152054	21	7	0.00284206252537556	2463	7161	26289,50808,4830,159,4833,204,4831	AK5,AK3,NME1,ADSS2,NME4,AK2,NME2
hsa_M00049	Adenine ribonucleotide biosynthesis, IMP => ADP,ATP	0.621482884050684	-0.475646908152054	21	7	0.00284206252537556	2463	7161	4831,204,4833,159,4830,50808,26289	NME2,AK2,NME4,ADSS2,NME1,AK3,AK5
ko00730	Thiamine metabolism	0.629655153946821	-0.462582984148359	15	5	0.00203004466098254	2463	7161	79178,26289,249,84284,204	THTPA,AK5,ALPL,NTPCR,AK2
hsa00790	Folate biosynthesis	0.629655153946821	-0.462582984148359	15	5	0.00203004466098254	2463	7161	5805,10243,249,8836,6697	PTS,GPHN,ALPL,GGH,SPR
hsa00730	Thiamine metabolism	0.629655153946821	-0.462582984148359	15	5	0.00203004466098254	2463	7161	84284,204,249,26289,79178	NTPCR,AK2,ALPL,AK5,THTPA
ko00790	Folate biosynthesis	0.629655153946821	-0.462582984148359	15	5	0.00203004466098254	2463	7161	8836,10243,5805,249,6697	GGH,GPHN,PTS,ALPL,SPR
M00004	Pentose phosphate pathway (Pentose phosphate cycle)	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	6120,2539,22934,8277	RPE,G6PD,RPIA,TKTL1
M00104	Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	1581,1593,10005,23600	CYP7A1,CYP27A1,ACOT8,AMACR
hsa_M00004	Pentose phosphate pathway (Pentose phosphate cycle)	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	6120,2539,22934,8277	RPE,G6PD,RPIA,TKTL1
hsa_M00052	Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	4830,51727,4833,4831	NME1,CMPK1,NME4,NME2
M00052	Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	4833,4831,51727,4830	NME4,NME2,CMPK1,NME1
M00094	Ceramide biosynthesis	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	29956,253782,8560,2531	CERS2,CERS6,DEGS1,KDSR
hsa_M00094	Ceramide biosynthesis	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	2531,8560,253782,29956	KDSR,DEGS1,CERS6,CERS2
hsa_M00104	Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate	0.636941136798735	-0.451078034589119	12	4	0.00162403572878603	2463	7161	23600,1593,1581,10005	AMACR,CYP27A1,CYP7A1,ACOT8
M00694	cGMP signaling	0.648609208934541	-0.432924887037432	9	3	0.00121802679658952	2463	7161	2983,4882,5138	GUCY1B1,NPR2,PDE2A
hsa_M00694	cGMP signaling	0.648609208934541	-0.432924887037432	9	3	0.00121802679658952	2463	7161	2983,5138,4882	GUCY1B1,PDE2A,NPR2
ko00010	Glycolysis / Gluconeogenesis	0.650772788291558	-0.429594717216473	67	22	0.00893219650832318	2463	7161	3945,5162,5236,669,1737,3939,2597,8789,92483,2023,125,2026,92579,5106,124,2203,5230,5223,220,55902,10327,5160	LDHB,PDHB,PGM1,BPGM,DLAT,LDHA,GAPDH,FBP2,LDHAL6B,ENO1,ADH1B,ENO2,G6PC3,PCK2,ADH1A,FBP1,PGK1,PGAM1,ALDH1A3,ACSS2,AKR1A1,PDHA1
hsa00010	Glycolysis / Gluconeogenesis	0.650772788291558	-0.429594717216473	67	22	0.00893219650832318	2463	7161	5230,10327,5160,55902,220,5223,2023,124,2203,5106,125,2026,92579,2597,1737,3939,8789,92483,669,5236,5162,3945	PGK1,AKR1A1,PDHA1,ACSS2,ALDH1A3,PGAM1,ENO1,ADH1A,FBP1,PCK2,ADH1B,ENO2,G6PC3,GAPDH,DLAT,LDHA,FBP2,LDHAL6B,BPGM,PGM1,PDHB,LDHB
ko04510	Focal adhesion	0.651071860470036	-0.429135258118917	198	66	0.0267965895249695	2463	7161	57144,7424,208,3725,3673,3693,5579,7059,7450,858,8503,5880,896,3479,572,6655,6093,4659,5290,5295,81,5728,3611,998,5296,207,7410,6464,394,5500,6696,1399,329,5602,859,857,595,3696,1499,5604,3913,56924,2002,10627,10000,824,60,5578,5908,103910,1278,3685,53358,3655,5501,4233,7143,7791,5906,5062,9475,3265,6714,7422,3480,5894	PAK5,VEGFC,AKT2,JUN,ITGA2,ITGB5,PRKCB,THBS3,VWF,CAV2,PIK3R3,RAC2,CCND3,IGF1,BAD,SOS2,ROCK1,PPP1R12A,PIK3CA,PIK3R1,ACTN4,PTEN,ILK,CDC42,PIK3R2,AKT1,VAV2,SHC1,ARHGAP5,PPP1CB,SPP1,CRKL,BIRC2,MAPK10,CAV3,CAV1,CCND1,ITGB8,CTNNB1,MAP2K1,LAMB2,PAK6,ELK1,MYL12A,AKT3,CAPN2,ACTB,PRKCA,RAP1B,MYL12B,COL1A2,ITGAV,SHC3,ITGA6,PPP1CC,MET,TNR,ZYX,RAP1A,PAK2,ROCK2,HRAS,SRC,VEGFA,IGF1R,RAF1
hsa04510	Focal adhesion	0.651071860470036	-0.429135258118917	198	66	0.0267965895249695	2463	7161	6655,572,6093,4659,5290,896,3479,858,8503,5880,7059,7450,5579,3673,3693,7424,208,3725,57144,859,857,595,5500,6696,1399,329,5602,394,7410,6464,207,998,5296,81,5728,3611,5295,103910,1278,5908,5578,60,824,10000,10627,1499,5604,56924,3913,2002,3696,5894,7422,3480,6714,3265,5906,7791,7143,5062,9475,4233,53358,3655,5501,3685	SOS2,BAD,ROCK1,PPP1R12A,PIK3CA,CCND3,IGF1,CAV2,PIK3R3,RAC2,THBS3,VWF,PRKCB,ITGA2,ITGB5,VEGFC,AKT2,JUN,PAK5,CAV3,CAV1,CCND1,PPP1CB,SPP1,CRKL,BIRC2,MAPK10,ARHGAP5,VAV2,SHC1,AKT1,CDC42,PIK3R2,ACTN4,PTEN,ILK,PIK3R1,MYL12B,COL1A2,RAP1B,PRKCA,ACTB,CAPN2,AKT3,MYL12A,CTNNB1,MAP2K1,PAK6,LAMB2,ELK1,ITGB8,RAF1,VEGFA,IGF1R,SRC,HRAS,RAP1A,ZYX,TNR,PAK2,ROCK2,MET,SHC3,ITGA6,PPP1CC,ITGAV
hsa04540	Gap junction	0.651362446512168	-0.428689038228369	88	29	0.0117742590336987	2463	7161	1812,6655,203068,5578,10383,5579,2697,983,108,5604,7846,2771,2983,5567,5894,2911,3265,6714,3356,23236,153,5330,109,10376,1902,2776,2767,3845,2773	DRD1,SOS2,TUBB,PRKCA,TUBB4B,PRKCB,GJA1,CDK1,ADCY2,MAP2K1,TUBA1A,GNAI2,GUCY1B1,PRKACB,RAF1,GRM1,HRAS,SRC,HTR2A,PLCB1,ADRB1,PLCB2,ADCY3,TUBA1B,LPAR1,GNAQ,GNA11,KRAS,GNAI3
ko04540	Gap junction	0.651362446512168	-0.428689038228369	88	29	0.0117742590336987	2463	7161	10383,5578,203068,6655,1812,2771,7846,5604,108,983,2697,5579,153,23236,6714,3356,3265,2911,5567,5894,2983,2773,3845,2767,2776,1902,10376,5330,109	TUBB4B,PRKCA,TUBB,SOS2,DRD1,GNAI2,TUBA1A,MAP2K1,ADCY2,CDK1,GJA1,PRKCB,ADRB1,PLCB1,SRC,HTR2A,HRAS,GRM1,PRKACB,RAF1,GUCY1B1,GNAI3,KRAS,GNA11,GNAQ,LPAR1,TUBA1B,PLCB2,ADCY3
hsa00140	Steroid hormone biosynthesis	0.651565117879239	-0.428377936714754	58	19	0.00771416971173366	2463	7161	1577,1589,1646,3290,1584,7923,1645,79799,8630,1312,1545,1585,79644,1543,1581,3292,3293,54658,1586	CYP3A5,CYP21A2,AKR1C2,HSD11B1,CYP11B1,HSD17B8,AKR1C1,UGT2A3,HSD17B6,COMT,CYP1B1,CYP11B2,SRD5A3,CYP1A1,CYP7A1,HSD17B1,HSD17B3,UGT1A1,CYP17A1
ko00140	Steroid hormone biosynthesis	0.651565117879239	-0.428377936714754	58	19	0.00771416971173366	2463	7161	1584,7923,1645,79799,1577,1589,1646,3290,54658,3293,3292,1586,8630,1312,79644,1545,1585,1543,1581	CYP11B1,HSD17B8,AKR1C1,UGT2A3,CYP3A5,CYP21A2,AKR1C2,HSD11B1,UGT1A1,HSD17B3,HSD17B1,CYP17A1,HSD17B6,COMT,SRD5A3,CYP1B1,CYP11B2,CYP1A1,CYP7A1
hsa00380	Tryptophan metabolism	0.657134102381868	-0.419867168111383	40	13	0.00527811611855461	2463	7161	316,3030,11185,55753,3620,1962,3033,15,38,1543,121278,1545,438	AOX1,HADHA,INMT,OGDHL,IDO1,EHHADH,HADH,AANAT,ACAT1,CYP1A1,TPH2,CYP1B1,ASMT
ko00380	Tryptophan metabolism	0.657134102381868	-0.419867168111383	40	13	0.00527811611855461	2463	7161	316,3033,3620,1962,11185,1543,38,121278,55753,1545,438,3030,15	AOX1,HADH,IDO1,EHHADH,INMT,CYP1A1,ACAT1,TPH2,OGDHL,CYP1B1,ASMT,HADHA,AANAT
hsa04710	Circadian rhythm	0.663934783256257	-0.409571352316971	31	10	0.00406008932196508	2463	7161	5571,6500,26224,5564,23291,1407,1454,6096,1385,8553	PRKAG1,SKP1,FBXL3,PRKAB1,FBXW11,CRY1,CSNK1E,RORB,CREB1,BHLHE40
ko04710	Circadian rhythm	0.663934783256257	-0.409571352316971	31	10	0.00406008932196508	2463	7161	1407,1454,8553,6096,1385,5571,26224,6500,23291,5564	CRY1,CSNK1E,BHLHE40,RORB,CREB1,PRKAG1,FBXL3,SKP1,FBXW11,PRKAB1
ko00630	Glyoxylate and dicarboxylate metabolism	0.667342155312198	-0.404452388113912	28	9	0.00365408038976857	2463	7161	4190,4594,50,38,5096,2752,48,275,6470	MDH1,MMUT,ACO2,ACAT1,PCCB,GLUL,ACO1,AMT,SHMT1
hsa00630	Glyoxylate and dicarboxylate metabolism	0.667342155312198	-0.404452388113912	28	9	0.00365408038976857	2463	7161	5096,38,4190,4594,50,6470,275,2752,48	PCCB,ACAT1,MDH1,MMUT,ACO2,SHMT1,AMT,GLUL,ACO1
M00013	Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	1962,3030	EHHADH,HADHA
M00141	C1-unit interconversion, eukaryotes	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	441024,6470	MTHFD2L,SHMT1
hsa_M00395	Decapping complex	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	167227,80153	DCP2,EDC3
M00073	N-glycan precursor trimming	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	10905,23193	MAN1A2,GANAB
M00395	Decapping complex	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	80153,167227	EDC3,DCP2
M00284	Origin recognition complex	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	23594,5001	ORC6,ORC5
hsa_M00073	N-glycan precursor trimming	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	23193,10905	GANAB,MAN1A2
hsa_M00141	C1-unit interconversion, eukaryotes	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	6470,441024	SHMT1,MTHFD2L
hsa00440	Phosphonate and phosphinate metabolism	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	85465,9468	SELENOI,PCYT1B
M00090	Phosphatidylcholine (PC) biosynthesis, choline => PC	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	1120,9468	CHKB,PCYT1B
hsa_M00284	Origin recognition complex	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	23594,5001	ORC6,ORC5
hsa_M00013	Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	1962,3030	EHHADH,HADHA
hsa_M00090	Phosphatidylcholine (PC) biosynthesis, choline => PC	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	1120,9468	CHKB,PCYT1B
ko00440	Phosphonate and phosphinate metabolism	0.669557044489427	-0.401138912866089	6	2	0.000812017864393017	2463	7161	9468,85465	PCYT1B,SELENOI
hsa04921	Oxytocin signaling pathway	0.681864075781438	-0.382924943375291	152	50	0.0203004466098254	2463	7161	5894,5567,2983,783,3265,6714,5535,1938,9475,4208,100137049,109,51806,2776,5501,2775,2353,5294,784,5564,785,5997,5578,60,5530,5604,2002,108,595,5500,5021,23236,8536,5330,4882,3845,3759,2773,4659,6093,5571,3760,4637,818,5579,10368,1026,952,3725,2771	RAF1,PRKACB,GUCY1B1,CACNB2,HRAS,SRC,PPP3R2,EEF2,ROCK2,MEF2C,PLA2G4B,ADCY3,CALML5,GNAQ,PPP1CC,GNAO1,FOS,PIK3CG,CACNB3,PRKAB1,CACNB4,RGS2,PRKCA,ACTB,PPP3CA,MAP2K1,ELK1,ADCY2,CCND1,PPP1CB,OXTR,PLCB1,CAMK1,PLCB2,NPR2,KRAS,KCNJ2,GNAI3,PPP1R12A,ROCK1,PRKAG1,KCNJ3,MYL6,CAMK2G,PRKCB,CACNG3,CDKN1A,CD38,JUN,GNAI2
hsa04145	Phagosome	0.681864075781438	-0.382924943375291	152	50	0.0203004466098254	2463	7161	3920,948,9146,9341,4973,7846,6441,30835,8992,60,10383,1781,3685,8417,53407,2213,29927,9550,23480,4360,653509,5868,3673,3693,533,23673,51382,528,203068,7037,90423,7097,4153,7059,10376,5878,55176,929,10952,534,10333,7099,2212,9554,523,64581,2209,1780,2204,811	LAMP2,CD36,HGS,VAMP3,OLR1,TUBA1A,SFTPD,CD209,ATP6V0E1,ACTB,TUBB4B,DYNC1I2,ITGAV,STX7,STX18,FCGR2B,SEC61A1,ATP6V1G1,SEC61G,MRC1,SFTPA1,RAB5A,ITGA2,ITGB5,ATP6V0B,STX12,ATP6V1D,ATP6V1C1,TUBB,TFRC,ATP6V1E2,TLR2,MBL2,THBS3,TUBA1B,RAB5C,SEC61A2,CD14,SEC61B,ATP6V1G2,TLR6,TLR4,FCGR2A,SEC22B,ATP6V1A,CLEC7A,FCGR1A,DYNC1I1,FCAR,CALR
ko04921	Oxytocin signaling pathway	0.681864075781438	-0.382924943375291	152	50	0.0203004466098254	2463	7161	5530,5604,2002,108,784,5294,5564,785,5997,5578,60,109,51806,2776,5501,2353,2775,5567,5894,2983,783,3265,6714,1938,5535,4208,100137049,9475,5579,10368,1026,952,3725,2771,4659,6093,3760,5571,818,4637,5330,8536,4882,3845,3759,2773,595,5500,5021,23236	PPP3CA,MAP2K1,ELK1,ADCY2,CACNB3,PIK3CG,PRKAB1,CACNB4,RGS2,PRKCA,ACTB,ADCY3,CALML5,GNAQ,PPP1CC,FOS,GNAO1,PRKACB,RAF1,GUCY1B1,CACNB2,HRAS,SRC,EEF2,PPP3R2,MEF2C,PLA2G4B,ROCK2,PRKCB,CACNG3,CDKN1A,CD38,JUN,GNAI2,PPP1R12A,ROCK1,KCNJ3,PRKAG1,CAMK2G,MYL6,PLCB2,CAMK1,NPR2,KRAS,KCNJ2,GNAI3,CCND1,PPP1CB,OXTR,PLCB1
ko04145	Phagosome	0.681864075781438	-0.382924943375291	152	50	0.0203004466098254	2463	7161	1780,2204,811,10333,7099,2212,9554,523,2209,64581,929,10952,534,5878,10376,55176,7097,4153,7059,528,7037,203068,90423,533,23673,51382,3673,3693,5868,2213,29927,9550,23480,653509,4360,3685,8417,53407,1781,30835,8992,60,10383,6441,9341,4973,7846,3920,948,9146	DYNC1I1,FCAR,CALR,TLR6,TLR4,FCGR2A,SEC22B,ATP6V1A,FCGR1A,CLEC7A,CD14,SEC61B,ATP6V1G2,RAB5C,TUBA1B,SEC61A2,TLR2,MBL2,THBS3,ATP6V1C1,TFRC,TUBB,ATP6V1E2,ATP6V0B,STX12,ATP6V1D,ITGA2,ITGB5,RAB5A,FCGR2B,SEC61A1,ATP6V1G1,SEC61G,SFTPA1,MRC1,ITGAV,STX7,STX18,DYNC1I2,CD209,ATP6V0E1,ACTB,TUBB4B,SFTPD,VAMP3,OLR1,TUBA1A,LAMP2,CD36,HGS
hsa05031	Amphetamine addiction	0.682162886134196	-0.382486813681552	68	22	0.00893219650832318	2463	7161	2353,6531,3725,84152,5501,1385,10488,51806,5530,5579,2890,2891,818,5578,5535,6804,148327,468,5173,5500,1812,5567	FOS,SLC6A3,JUN,PPP1R1B,PPP1CC,CREB1,CREB3,CALML5,PPP3CA,PRKCB,GRIA1,GRIA2,CAMK2G,PRKCA,PPP3R2,STX1A,CREB3L4,ATF4,PDYN,PPP1CB,DRD1,PRKACB
ko05031	Amphetamine addiction	0.682162886134196	-0.382486813681552	68	22	0.00893219650832318	2463	7161	818,5578,1812,3725,5530,10488,5579,2891,6804,5535,5173,5500,148327,468,5567,6531,2353,5501,1385,84152,51806,2890	CAMK2G,PRKCA,DRD1,JUN,PPP3CA,CREB3,PRKCB,GRIA2,STX1A,PPP3R2,PDYN,PPP1CB,CREB3L4,ATF4,PRKACB,SLC6A3,FOS,PPP1CC,CREB1,PPP1R1B,CALML5,GRIA1
ko00600	Sphingolipid metabolism	0.691645555993971	-0.368681656905737	47	15	0.00609013398294762	2463	7161	253782,55331,9514,64781,4758,259230,29956,7357,8560,166929,56848,2531,6610,2581,9331	CERS6,ACER3,GAL3ST1,CERK,NEU1,SGMS1,CERS2,UGCG,DEGS1,SGMS2,SPHK2,KDSR,SMPD2,GALC,B4GALT6
hsa00600	Sphingolipid metabolism	0.691645555993971	-0.368681656905737	47	15	0.00609013398294762	2463	7161	2531,56848,2581,9331,6610,8560,7357,166929,64781,4758,259230,29956,253782,9514,55331	KDSR,SPHK2,GALC,B4GALT6,SMPD2,DEGS1,UGCG,SGMS2,CERK,NEU1,SGMS1,CERS2,CERS6,GAL3ST1,ACER3
M00695	cAMP signaling	0.693385974776591	-0.366168472678507	16	5	0.00203004466098254	2463	7161	109,108,5567,2773,2771	ADCY3,ADCY2,PRKACB,GNAI3,GNAI2
hsa_M00695	cAMP signaling	0.693385974776591	-0.366168472678507	16	5	0.00203004466098254	2463	7161	2773,2771,5567,109,108	GNAI3,GNAI2,PRKACB,ADCY3,ADCY2
hsa00270	Cysteine and methionine metabolism	0.693964768538354	-0.365334085558838	44	14	0.00568412505075112	2463	7161	92483,1036,6723,27430,4507,7263,3939,4357,4144,2729,4190,10768,10993,3945	LDHAL6B,CDO1,SRM,MAT2B,MTAP,TST,LDHA,MPST,MAT2A,GCLC,MDH1,AHCYL1,SDS,LDHB
ko00270	Cysteine and methionine metabolism	0.693964768538354	-0.365334085558838	44	14	0.00568412505075112	2463	7161	3939,27430,7263,4507,92483,6723,1036,3945,10768,4190,10993,4357,2729,4144	LDHA,MAT2B,TST,MTAP,LDHAL6B,SRM,CDO1,LDHB,AHCYL1,MDH1,SDS,MPST,GCLC,MAT2A
hsa04650	Natural killer cell mediated cytotoxicity	0.701810766071009	-0.354091475296643	132	43	0.0174583840844499	2463	7161	3822,3265,3459,5535,6464,7410,919,5894,4277,10870,3454,356,259197,3440,5781,3383,53358,3845,6850,1437,5295,3458,5296,8503,5578,5880,2207,7124,6655,4068,5290,3447,3937,3384,5604,7305,355,3446,5579,5530,8743,3824,3456	KLRC2,HRAS,IFNGR1,PPP3R2,SHC1,VAV2,CD247,RAF1,MICB,HCST,IFNAR1,FASLG,NCR3,IFNA2,PTPN11,ICAM1,SHC3,KRAS,SYK,CSF2,PIK3R1,IFNG,PIK3R2,PIK3R3,PRKCA,RAC2,FCER1G,TNF,SOS2,SH2D1A,PIK3CA,IFNA13,LCP2,ICAM2,MAP2K1,TYROBP,FAS,IFNA10,PRKCB,PPP3CA,TNFSF10,KLRD1,IFNB1
ko04650	Natural killer cell mediated cytotoxicity	0.701810766071009	-0.354091475296643	132	43	0.0174583840844499	2463	7161	5880,5578,8503,2207,5290,4068,6655,7124,3937,3447,5604,3384,7305,3446,5579,355,3456,8743,3824,5530,5535,3459,3265,3822,7410,6464,3454,10870,5894,4277,919,5781,3383,259197,3440,356,6850,3845,53358,1437,5295,3458,5296	RAC2,PRKCA,PIK3R3,FCER1G,PIK3CA,SH2D1A,SOS2,TNF,LCP2,IFNA13,MAP2K1,ICAM2,TYROBP,IFNA10,PRKCB,FAS,IFNB1,TNFSF10,KLRD1,PPP3CA,PPP3R2,IFNGR1,HRAS,KLRC2,VAV2,SHC1,IFNAR1,HCST,RAF1,MICB,CD247,PTPN11,ICAM1,NCR3,IFNA2,FASLG,SYK,KRAS,SHC3,CSF2,PIK3R1,IFNG,PIK3R2
ko04114	Oocyte meiosis	0.702040306752946	-0.353764459577632	120	39	0.0158343483556638	2463	7161	5518,10459,8881,3479,367,51529,7529,818,25847,7532,7533,5530,983,29882,8697,991,6500,891,5525,4085,64506,5604,108,3480,5500,9232,5567,388333,5516,29945,5529,5535,51806,7534,5241,23291,109,246184,5501	PPP2R1A,MAD2L2,CDC16,IGF1,AR,ANAPC11,YWHAB,CAMK2G,ANAPC13,YWHAG,YWHAH,PPP3CA,CDK1,ANAPC2,CDC23,CDC20,SKP1,CCNB1,PPP2R5A,MAD2L1,CPEB1,MAP2K1,ADCY2,IGF1R,PPP1CB,PTTG1,PRKACB,SPDYE4,PPP2CB,ANAPC4,PPP2R5E,PPP3R2,CALML5,YWHAZ,PGR,FBXW11,ADCY3,CDC26,PPP1CC
hsa04114	Oocyte meiosis	0.702040306752946	-0.353764459577632	120	39	0.0158343483556638	2463	7161	5530,983,8697,29882,6500,991,891,4085,5525,64506,5604,108,5518,3479,8881,10459,51529,367,7529,7532,7533,25847,818,7534,51806,5241,109,23291,246184,5501,5500,3480,388333,5567,9232,5516,29945,5529,5535	PPP3CA,CDK1,CDC23,ANAPC2,SKP1,CDC20,CCNB1,MAD2L1,PPP2R5A,CPEB1,MAP2K1,ADCY2,PPP2R1A,IGF1,CDC16,MAD2L2,ANAPC11,AR,YWHAB,YWHAG,YWHAH,ANAPC13,CAMK2G,YWHAZ,CALML5,PGR,ADCY3,FBXW11,CDC26,PPP1CC,PPP1CB,IGF1R,SPDYE4,PRKACB,PTTG1,PPP2CB,ANAPC4,PPP2R5E,PPP3R2
hsa_M00005	PRPP biosynthesis, ribose 5P => PRPP	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	5631	PRPS1
M00400	p97-Ufd1-Npl4 complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	7353	UFD1
M00297	DNA-PK complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	7520	XRCC5
hsa_M00118	Glutathione biosynthesis, glutamate => glutathione	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	2729	GCLC
M00100	Sphingosine degradation	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	56848	SPHK2
M00051	Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	7372	UMPS
hsa_M00051	Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	7372	UMPS
M00005	PRPP biosynthesis, ribose 5P => PRPP	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	5631	PRPS1
hsa_M00400	p97-Ufd1-Npl4 complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	7353	UFD1
hsa_M00408	ESCRT-0 complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	9146	HGS
hsa_M00291	MRN complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	4683	NBN
M00291	MRN complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	4683	NBN
hsa_M00392	Ski complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	80349	SKIC8
hsa_M00100	Sphingosine degradation	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	56848	SPHK2
M00408	ESCRT-0 complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	9146	HGS
M00392	Ski complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	80349	SKIC8
M00118	Glutathione biosynthesis, glutamate => glutathione	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	2729	GCLC
hsa_M00297	DNA-PK complex	0.717692378884754	-0.331714243405954	3	1	0.000406008932196508	2463	7161	7520	XRCC5
M00426	Survival motor neuron (SMN) complex	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	79760,6606,54960	GEMIN7,SMN1,GEMIN8
ko00072	Synthesis and degradation of ketone bodies	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	5019,38,3157	OXCT1,ACAT1,HMGCS1
hsa00072	Synthesis and degradation of ketone bodies	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	3157,38,5019	HMGCS1,ACAT1,OXCT1
hsa_M00035	Methionine degradation	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	27430,4144,10768	MAT2B,MAT2A,AHCYL1
hsa_M00426	Survival motor neuron (SMN) complex	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	54960,79760,6606	GEMIN8,GEMIN7,SMN1
M00035	Methionine degradation	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	4144,10768,27430	MAT2A,AHCYL1,MAT2B
M00095	C5 isoprenoid biosynthesis, mevalonate pathway	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	38,3157,4597	ACAT1,HMGCS1,MVD
hsa_M00095	C5 isoprenoid biosynthesis, mevalonate pathway	0.725276314750246	-0.321202572943244	10	3	0.00121802679658952	2463	7161	3157,4597,38	HMGCS1,MVD,ACAT1
ko00280	Valine, leucine and isoleucine degradation	0.726400867487645	-0.319653257467181	48	15	0.00609013398294762	2463	7161	1629,35,316,549,3030,3028,5019,1962,3033,36,10449,3157,4594,38,5096	DBT,ACADS,AOX1,AUH,HADHA,HSD17B10,OXCT1,EHHADH,HADH,ACADSB,ACAA2,HMGCS1,MMUT,ACAT1,PCCB
hsa00280	Valine, leucine and isoleucine degradation	0.726400867487645	-0.319653257467181	48	15	0.00609013398294762	2463	7161	36,4594,3157,10449,5096,38,1962,3033,549,3030,3028,5019,1629,316,35	ACADSB,MMUT,HMGCS1,ACAA2,PCCB,ACAT1,EHHADH,HADH,AUH,HADHA,HSD17B10,OXCT1,DBT,AOX1,ACADS
hsa04750	Inflammatory mediator regulation of TRP channels	0.728719804227696	-0.316465977197919	97	31	0.0125862768980918	2463	7161	5500,5602,5588,5567,5732,5606,5581,23236,100137049,41,3356,6714,5296,51806,2776,109,5330,5295,40,5501,3553,3479,5290,3556,8503,5578,818,5608,5579,5734,108	PPP1CB,MAPK10,PRKCQ,PRKACB,PTGER2,MAP2K3,PRKCE,PLCB1,PLA2G4B,ASIC1,HTR2A,SRC,PIK3R2,CALML5,GNAQ,ADCY3,PLCB2,PIK3R1,ASIC2,PPP1CC,IL1B,IGF1,PIK3CA,IL1RAP,PIK3R3,PRKCA,CAMK2G,MAP2K6,PRKCB,PTGER4,ADCY2
ko04750	Inflammatory mediator regulation of TRP channels	0.728719804227696	-0.316465977197919	97	31	0.0125862768980918	2463	7161	5734,108,5579,3556,818,5608,5578,8503,3479,3553,5290,5295,5501,40,2776,51806,5296,5330,109,23236,100137049,5606,5581,3356,41,6714,5602,5500,5732,5567,5588	PTGER4,ADCY2,PRKCB,IL1RAP,CAMK2G,MAP2K6,PRKCA,PIK3R3,IGF1,IL1B,PIK3CA,PIK3R1,PPP1CC,ASIC2,GNAQ,CALML5,PIK3R2,PLCB2,ADCY3,PLCB1,PLA2G4B,MAP2K3,PRKCE,HTR2A,ASIC1,SRC,MAPK10,PPP1CB,PTGER2,PRKACB,PRKCQ
hsa00670	One carbon pool by folate	0.73677590502779	-0.305471496763893	20	6	0.00243605359317905	2463	7161	7298,10840,441024,10588,6470,275	TYMS,ALDH1L1,MTHFD2L,MTHFS,SHMT1,AMT
ko00670	One carbon pool by folate	0.73677590502779	-0.305471496763893	20	6	0.00243605359317905	2463	7161	441024,10588,7298,10840,275,6470	MTHFD2L,MTHFS,TYMS,ALDH1L1,AMT,SHMT1
hsa04215	Apoptosis - multiple species	0.747972955332909	-0.290388457633349	33	10	0.00406008932196508	2463	7161	27429,329,5602,598,581,8678,578,666,5366,332	HTRA2,BIRC2,MAPK10,BCL2L1,BAX,BECN1,BAK1,BOK,PMAIP1,BIRC5
ko04215	Apoptosis - multiple species	0.747972955332909	-0.290388457633349	33	10	0.00406008932196508	2463	7161	8678,581,5602,598,329,5366,332,666,578,27429	BECN1,BAX,MAPK10,BCL2L1,BIRC2,PMAIP1,BIRC5,BOK,BAK1,HTRA2
hsa00910	Nitrogen metabolism	0.749127772262501	-0.288845719543189	17	5	0.00203004466098254	2463	7161	2752,23632,760,767,771	GLUL,CA14,CA2,CA8,CA12
ko00910	Nitrogen metabolism	0.749127772262501	-0.288845719543189	17	5	0.00203004466098254	2463	7161	760,2752,23632,771,767	CA2,GLUL,CA14,CA12,CA8
ko04916	Melanogenesis	0.750857691111825	-0.28653913770151	101	32	0.0129922858302883	2463	7161	5578,818,7480,1499,5604,108,3815,7472,2771,4286,5579,7476,10488,1856,8322,8323,3265,2033,23236,5894,5567,1387,148327,1385,3845,2773,2775,7976,109,5330,51806,2776	PRKCA,CAMK2G,WNT10B,CTNNB1,MAP2K1,ADCY2,KIT,WNT2,GNAI2,MITF,PRKCB,WNT7A,CREB3,DVL2,FZD4,FZD6,HRAS,EP300,PLCB1,RAF1,PRKACB,CREBBP,CREB3L4,CREB1,KRAS,GNAI3,GNAO1,FZD3,ADCY3,PLCB2,CALML5,GNAQ
hsa04916	Melanogenesis	0.750857691111825	-0.28653913770151	101	32	0.0129922858302883	2463	7161	7976,109,5330,51806,2776,1385,3845,2773,2775,5894,5567,1387,148327,1856,8322,8323,3265,2033,23236,5579,7476,10488,1499,5604,108,3815,7472,4286,2771,5578,818,7480	FZD3,ADCY3,PLCB2,CALML5,GNAQ,CREB1,KRAS,GNAI3,GNAO1,RAF1,PRKACB,CREBBP,CREB3L4,DVL2,FZD4,FZD6,HRAS,EP300,PLCB1,PRKCB,WNT7A,CREB3,CTNNB1,MAP2K1,ADCY2,KIT,WNT2,MITF,GNAI2,PRKCA,CAMK2G,WNT10B
hsa04972	Pancreatic secretion	0.753073799749359	-0.283592048349408	95	30	0.0121802679658952	2463	7161	5322,477,23436,5330,1080,109,2776,5906,8766,23236,476,280,952,108,7220,1131,9545,760,6558,5579,478,5908,5578,5644,81579,3778,1179,493,481,483	PLA2G5,ATP1A2,CELA3B,PLCB2,CFTR,ADCY3,GNAQ,RAP1A,RAB11A,PLCB1,ATP1A1,AMY2B,CD38,ADCY2,TRPC1,CHRM3,RAB3D,CA2,SLC12A2,PRKCB,ATP1A3,RAP1B,PRKCA,PRSS1,PLA2G12A,KCNMA1,CLCA1,ATP2B4,ATP1B1,ATP1B3
ko04972	Pancreatic secretion	0.753073799749359	-0.283592048349408	95	30	0.0121802679658952	2463	7161	280,476,8766,5906,23236,2776,109,5330,1080,23436,477,5322,483,481,1179,493,81579,3778,5644,5578,5908,6558,760,478,5579,9545,952,1131,108,7220	AMY2B,ATP1A1,RAB11A,RAP1A,PLCB1,GNAQ,ADCY3,PLCB2,CFTR,CELA3B,ATP1A2,PLA2G5,ATP1B3,ATP1B1,CLCA1,ATP2B4,PLA2G12A,KCNMA1,PRSS1,PRKCA,RAP1B,SLC12A2,CA2,ATP1A3,PRKCB,RAB3D,CD38,CHRM3,ADCY2,TRPC1
ko00030	Pentose phosphate pathway	0.754536064115539	-0.28165220322134	30	9	0.00365408038976857	2463	7161	6120,9104,5631,8277,2203,8789,2539,22934,5236	RPE,RGN,PRPS1,TKTL1,FBP1,FBP2,G6PD,RPIA,PGM1
hsa00030	Pentose phosphate pathway	0.754536064115539	-0.28165220322134	30	9	0.00365408038976857	2463	7161	8277,2203,8789,6120,5631,9104,5236,2539,22934	TKTL1,FBP1,FBP2,RPE,PRPS1,RGN,PGM1,G6PD,RPIA
hsa05320	Autoimmune thyroid disease	0.75504547280226	-0.280977302669633	52	16	0.00649614291514413	2463	7161	941,3446,3565,7253,355,3567,1493,958,3586,3558,940,356,3440,3447,959,942	CD80,IFNA10,IL4,TSHR,FAS,IL5,CTLA4,CD40,IL10,IL2,CD28,FASLG,IFNA2,IFNA13,CD40LG,CD86
ko05320	Autoimmune thyroid disease	0.75504547280226	-0.280977302669633	52	16	0.00649614291514413	2463	7161	941,355,7253,3565,3446,1493,3567,3558,958,3586,356,3440,3447,940,942,959	CD80,FAS,TSHR,IL4,IFNA10,CTLA4,IL5,IL2,CD40,IL10,FASLG,IFNA2,IFNA13,CD28,CD86,CD40LG
hsa_M00047	Creatine pathway	0.755855359039694	-0.279905245128948	7	2	0.000812017864393017	2463	7161	2593,1152	GAMT,CKB
M00549	Nucleotide sugar biosynthesis, glucose => UDP-glucose	0.755855359039694	-0.279905245128948	7	2	0.000812017864393017	2463	7161	5236,7360	PGM1,UGP2
hsa_M00549	Nucleotide sugar biosynthesis, glucose => UDP-glucose	0.755855359039694	-0.279905245128948	7	2	0.000812017864393017	2463	7161	7360,5236	UGP2,PGM1
M00047	Creatine pathway	0.755855359039694	-0.279905245128948	7	2	0.000812017864393017	2463	7161	1152,2593	CKB,GAMT
hsa04261	Adrenergic signaling in cardiomyocytes	0.760942625581345	-0.273197317416893	144	46	0.0186764108810394	2463	7161	468,148327,783,5500,476,5516,5567,23236,153,5529,2776,51806,109,6324,5330,6546,207,2773,7139,7170,1385,477,5501,483,481,785,5518,493,5294,784,5578,818,154,10000,10488,10368,478,5350,148,5523,5522,2771,5525,208,108,5502	ATF4,CREB3L4,CACNB2,PPP1CB,ATP1A1,PPP2CB,PRKACB,PLCB1,ADRB1,PPP2R5E,GNAQ,CALML5,ADCY3,SCN1B,PLCB2,SLC8A1,AKT1,GNAI3,TNNT2,TPM3,CREB1,ATP1A2,PPP1CC,ATP1B3,ATP1B1,CACNB4,PPP2R1A,ATP2B4,PIK3CG,CACNB3,PRKCA,CAMK2G,ADRB2,AKT3,CREB3,CACNG3,ATP1A3,PLN,ADRA1A,PPP2R3A,PPP2R2C,GNAI2,PPP2R5A,AKT2,ADCY2,PPP1R1A
ko04261	Adrenergic signaling in cardiomyocytes	0.760942625581345	-0.273197317416893	144	46	0.0186764108810394	2463	7161	481,483,785,5518,493,5294,784,5578,818,154,10000,10488,10368,478,5350,148,5523,5522,2771,5525,208,108,5502,468,148327,783,5500,476,5516,5567,23236,153,5529,2776,51806,109,6324,6546,5330,207,2773,7139,7170,477,1385,5501	ATP1B1,ATP1B3,CACNB4,PPP2R1A,ATP2B4,PIK3CG,CACNB3,PRKCA,CAMK2G,ADRB2,AKT3,CREB3,CACNG3,ATP1A3,PLN,ADRA1A,PPP2R3A,PPP2R2C,GNAI2,PPP2R5A,AKT2,ADCY2,PPP1R1A,ATF4,CREB3L4,CACNB2,PPP1CB,ATP1A1,PPP2CB,PRKACB,PLCB1,ADRB1,PPP2R5E,GNAQ,CALML5,ADCY3,SCN1B,SLC8A1,PLCB2,AKT1,GNAI3,TNNT2,TPM3,ATP1A2,CREB1,PPP1CC
ko04966	Collecting duct acid secretion	0.762294078279095	-0.271422868247001	27	8	0.00324807145757207	2463	7161	51382,534,8992,523,90423,9550,760,528	ATP6V1D,ATP6V1G2,ATP6V0E1,ATP6V1A,ATP6V1E2,ATP6V1G1,CA2,ATP6V1C1
hsa04966	Collecting duct acid secretion	0.762294078279095	-0.271422868247001	27	8	0.00324807145757207	2463	7161	8992,534,51382,528,760,90423,523,9550	ATP6V0E1,ATP6V1G2,ATP6V1D,ATP6V1C1,CA2,ATP6V1E2,ATP6V1A,ATP6V1G1
hsa_M00055	N-glycan precursor biosynthesis	0.76547255674898	-0.267261914626336	14	4	0.00162403572878603	2463	7161	440138,29880,1798,85365	ALG11,ALG5,DPAGT1,ALG2
M00055	N-glycan precursor biosynthesis	0.76547255674898	-0.267261914626336	14	4	0.00162403572878603	2463	7161	29880,440138,85365,1798	ALG5,ALG11,ALG2,DPAGT1
hsa04976	Bile secretion	0.766334580847952	-0.266136414987627	71	22	0.00893219650832318	2463	7161	6579,483,481,5567,9429,200931,476,361,3949,2052,28234,5243,760,1080,109,478,1581,6513,1244,9376,477,108	SLCO1A2,ATP1B3,ATP1B1,PRKACB,ABCG2,SLC51A,ATP1A1,AQP4,LDLR,EPHX1,SLCO1B3,ABCB1,CA2,CFTR,ADCY3,ATP1A3,CYP7A1,SLC2A1,ABCC2,SLC22A8,ATP1A2,ADCY2
ko04976	Bile secretion	0.766334580847952	-0.266136414987627	71	22	0.00893219650832318	2463	7161	6513,1581,477,9376,1244,108,28234,5243,760,478,109,1080,361,2052,3949,483,481,6579,9429,5567,476,200931	SLC2A1,CYP7A1,ATP1A2,SLC22A8,ABCC2,ADCY2,SLCO1B3,ABCB1,CA2,ATP1A3,ADCY3,CFTR,AQP4,EPHX1,LDLR,ATP1B3,ATP1B1,SLCO1A2,ABCG2,PRKACB,ATP1A1,SLC51A
ko04970	Salivary secretion	0.778365322638338	-0.25055929864235	90	28	0.0113682501015022	2463	7161	108,1131,4069,952,5579,478,148,6558,1471,155,3778,5578,154,481,483,820,493,6844,477,2776,51806,5330,109,23236,153,2983,476,5567	ADCY2,CHRM3,LYZ,CD38,PRKCB,ATP1A3,ADRA1A,SLC12A2,CST3,ADRB3,KCNMA1,PRKCA,ADRB2,ATP1B1,ATP1B3,CAMP,ATP2B4,VAMP2,ATP1A2,GNAQ,CALML5,PLCB2,ADCY3,PLCB1,ADRB1,GUCY1B1,ATP1A1,PRKACB
hsa04970	Salivary secretion	0.778365322638338	-0.25055929864235	90	28	0.0113682501015022	2463	7161	952,4069,1131,108,148,6558,478,5579,155,3778,1471,154,5578,481,820,483,493,6844,477,51806,2776,109,5330,153,23236,5567,476,2983	CD38,LYZ,CHRM3,ADCY2,ADRA1A,SLC12A2,ATP1A3,PRKCB,ADRB3,KCNMA1,CST3,ADRB2,PRKCA,ATP1B1,CAMP,ATP1B3,ATP2B4,VAMP2,ATP1A2,CALML5,GNAQ,ADCY3,PLCB2,ADRB1,PLCB1,PRKACB,ATP1A1,GUCY1B1
ko00130	Ubiquinone and other terpenoid-quinone biosynthesis	0.788142591042093	-0.238076252395193	11	3	0.00121802679658952	2463	7161	1728,154807,2677	NQO1,VKORC1L1,GGCX
M00404	COPII complex	0.788142591042093	-0.238076252395193	11	3	0.00121802679658952	2463	7161	10484,6396,51128	SEC23A,SEC13,SAR1B
hsa_M00404	COPII complex	0.788142591042093	-0.238076252395193	11	3	0.00121802679658952	2463	7161	10484,6396,51128	SEC23A,SEC13,SAR1B
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	0.788142591042093	-0.238076252395193	11	3	0.00121802679658952	2463	7161	2677,1728,154807	GGCX,NQO1,VKORC1L1
hsa00512	Mucin type O-glycan biosynthesis	0.791600224465017	-0.23369878169513	31	9	0.00365408038976857	2463	7161	64409,9245,29071,6482,6483,79695,8693,2590,2589	GALNT17,GCNT3,C1GALT1C1,ST3GAL1,ST3GAL2,GALNT12,GALNT4,GALNT2,GALNT1
ko00512	Mucin type O-glycan biosynthesis	0.791600224465017	-0.23369878169513	31	9	0.00365408038976857	2463	7161	6483,6482,29071,64409,9245,2590,2589,8693,79695	ST3GAL2,ST3GAL1,C1GALT1C1,GALNT17,GCNT3,GALNT2,GALNT1,GALNT4,GALNT12
hsa00071	Fatty acid degradation	0.797581336050471	-0.226171460745619	44	13	0.00527811611855461	2463	7161	36,1376,10449,38,2182,1375,124,1962,125,3033,51,3030,35	ACADSB,CPT2,ACAA2,ACAT1,ACSL4,CPT1B,ADH1A,EHHADH,ADH1B,HADH,ACOX1,HADHA,ACADS
ko00071	Fatty acid degradation	0.797581336050471	-0.226171460745619	44	13	0.00527811611855461	2463	7161	38,2182,36,1376,10449,125,3033,1375,124,1962,51,3030,35	ACAT1,ACSL4,ACADSB,CPT2,ACAA2,ADH1B,HADH,CPT1B,ADH1A,EHHADH,ACOX1,HADHA,ACADS
hsa00650	Butanoate metabolism	0.800274847462624	-0.222800050988922	28	8	0.00324807145757207	2463	7161	3033,2572,35,1962,38,5019,3157,3030	HADH,GAD2,ACADS,EHHADH,ACAT1,OXCT1,HMGCS1,HADHA
ko00650	Butanoate metabolism	0.800274847462624	-0.222800050988922	28	8	0.00324807145757207	2463	7161	3030,3157,5019,38,1962,2572,35,3033	HADHA,HMGCS1,OXCT1,ACAT1,EHHADH,GAD2,ACADS,HADH
hsa05332	Graft-versus-host disease	0.803134368932126	-0.219233245370174	41	12	0.0048721071863581	2463	7161	3824,941,355,3458,940,356,3553,3552,3569,7124,942,3558	KLRD1,CD80,FAS,IFNG,CD28,FASLG,IL1B,IL1A,IL6,TNF,CD86,IL2
ko05332	Graft-versus-host disease	0.803134368932126	-0.219233245370174	41	12	0.0048721071863581	2463	7161	941,3824,3458,355,3558,3552,3553,356,3569,940,7124,942	CD80,KLRD1,IFNG,FAS,IL2,IL1A,IL1B,FASLG,IL6,CD28,TNF,CD86
ko03440	Homologous recombination	0.803134368932126	-0.219233245370174	41	12	0.0048721071863581	2463	7161	8940,29086,11073,57804,5932,672,6742,6118,4683,7979,6119,5425	TOP3B,BABAM1,TOPBP1,POLD4,RBBP8,BRCA1,SSBP1,RPA2,NBN,SEM1,RPA3,POLD2
hsa03440	Homologous recombination	0.803134368932126	-0.219233245370174	41	12	0.0048721071863581	2463	7161	672,5932,6742,6118,4683,11073,29086,8940,57804,5425,7979,6119	BRCA1,RBBP8,SSBP1,RPA2,NBN,TOPBP1,BABAM1,TOP3B,POLD4,POLD2,SEM1,RPA3
hsa04925	Aldosterone synthesis and secretion	0.805879114683069	-0.215821529506694	82	25	0.0101502233049127	2463	7161	5330,109,8536,51806,2776,1385,2767,5567,6770,148327,468,1589,5581,23683,23236,5579,4929,10488,466,108,1585,5138,3949,818,5578	PLCB2,ADCY3,CAMK1,CALML5,GNAQ,CREB1,GNA11,PRKACB,STAR,CREB3L4,ATF4,CYP21A2,PRKCE,PRKD3,PLCB1,PRKCB,NR4A2,CREB3,ATF1,ADCY2,CYP11B2,PDE2A,LDLR,CAMK2G,PRKCA
ko04925	Aldosterone synthesis and secretion	0.805879114683069	-0.215821529506694	82	25	0.0101502233049127	2463	7161	1589,23236,23683,5581,5567,468,148327,6770,2767,1385,8536,109,5330,2776,51806,5578,3949,818,5138,108,1585,5579,466,10488,4929	CYP21A2,PLCB1,PRKD3,PRKCE,PRKACB,ATF4,CREB3L4,STAR,GNA11,CREB1,CAMK1,ADCY3,PLCB2,GNAQ,CALML5,PRKCA,LDLR,CAMK2G,PDE2A,ADCY2,CYP11B2,PRKCB,ATF1,CREB3,NR4A2
ko00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0.810464672401816	-0.2101475261693	25	7	0.00284206252537556	2463	7161	8818,10026,5279,284098,8733,84992,5277	DPM2,PIGK,PIGC,PIGW,GPAA1,PIGY,PIGA
hsa00563	Glycosylphosphatidylinositol (GPI)-anchor biosynthesis	0.810464672401816	-0.2101475261693	25	7	0.00284206252537556	2463	7161	8818,10026,5279,284098,8733,5277,84992	DPM2,PIGK,PIGC,PIGW,GPAA1,PIGA,PIGY
ko00290	Valine, leucine and isoleucine biosynthesis	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	10993	SDS
M00110	C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	1586	CYP17A1
hsa_M00006	Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	2539	G6PD
hsa_M00381	SCF-SKP2 complex	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	6500	SKP1
M00632	Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	2582	GALE
M00690	MAPK (ERK5) signaling	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	4215	MAP3K3
hsa_M00690	MAPK (ERK5) signaling	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	4215	MAP3K3
hsa_M00632	Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	2582	GALE
hsa00290	Valine, leucine and isoleucine biosynthesis	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	10993	SDS
hsa_M00110	C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	1586	CYP17A1
M00381	SCF-SKP2 complex	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	6500	SKP1
hsa_M00027	GABA (gamma-Aminobutyrate) shunt	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	2572	GAD2
M00027	GABA (gamma-Aminobutyrate) shunt	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	2572	GAD2
M00006	Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P	0.814831757316826	-0.204773619791536	4	1	0.000406008932196508	2463	7161	2539	G6PD
ko00740	Riboflavin metabolism	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	54,53	ACP5,ACP2
hsa_M00409	ESCRT-I complex	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	51160,7251	VPS28,TSG101
M00687	MAPK (ERK1/2) signaling	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	5894,5604	RAF1,MAP2K1
M00065	GPI-anchor biosynthesis, core oligosaccharide	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	5277,284098	PIGA,PIGW
hsa_M00687	MAPK (ERK1/2) signaling	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	5894,5604	RAF1,MAP2K1
hsa00740	Riboflavin metabolism	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	53,54	ACP2,ACP5
M00409	ESCRT-I complex	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	51160,7251	VPS28,TSG101
hsa_M00065	GPI-anchor biosynthesis, core oligosaccharide	0.821901998022504	-0.196134114850586	8	2	0.000812017864393017	2463	7161	5277,284098	PIGA,PIGW
hsa_M00689	MAPK (p38) signaling	0.822592908810903	-0.19529384368139	22	6	0.00243605359317905	2463	7161	7786,4296,5606,5608,84451,4215	MAP3K12,MAP3K11,MAP2K3,MAP2K6,MAP3K21,MAP3K3
ko00514	Other types of O-glycan biosynthesis	0.822592908810903	-0.19529384368139	22	6	0.00243605359317905	2463	7161	29954,727936,8703,2683,6480,283464	POMT2,GXYLT2,B4GALT3,B4GALT1,ST6GAL1,GXYLT1
M00689	MAPK (p38) signaling	0.822592908810903	-0.19529384368139	22	6	0.00243605359317905	2463	7161	4215,84451,5608,5606,4296,7786	MAP3K3,MAP3K21,MAP2K6,MAP2K3,MAP3K11,MAP3K12
hsa00514	Other types of O-glycan biosynthesis	0.822592908810903	-0.19529384368139	22	6	0.00243605359317905	2463	7161	8703,2683,29954,727936,283464,6480	B4GALT3,B4GALT1,POMT2,GXYLT2,GXYLT1,ST6GAL1
hsa04390	Hippo signaling pathway	0.825529521723465	-0.191730254028258	154	48	0.0194884287454324	2463	7161	7480,7532,7529,4771,2246,50855,657,896,659,6788,5522,7472,1742,7476,4086,8322,1495,658,595,1496,329,5500,7043,23291,4088,7533,60,4087,1739,5518,1499,6657,60485,4609,3397,7048,4089,8323,1856,5516,332,5501,1454,7042,7976,6591,1741,7534	WNT10B,YWHAG,YWHAB,NF2,FGF1,PARD6A,BMPR1A,CCND3,BMPR2,STK3,PPP2R2C,WNT2,DLG4,WNT7A,SMAD1,FZD4,CTNNA1,BMPR1B,CCND1,CTNNA2,BIRC2,PPP1CB,TGFB3,FBXW11,SMAD3,YWHAH,ACTB,SMAD2,DLG1,PPP2R1A,CTNNB1,SOX2,SAV1,MYC,ID1,TGFBR2,SMAD4,FZD6,DVL2,PPP2CB,BIRC5,PPP1CC,CSNK1E,TGFB2,FZD3,SNAI2,DLG3,YWHAZ
ko04390	Hippo signaling pathway	0.825529521723465	-0.191730254028258	154	48	0.0194884287454324	2463	7161	1739,5518,4087,60,7533,4609,3397,7048,6657,60485,1499,5516,332,4089,8323,1856,1741,7534,7976,6591,1454,7042,5501,657,896,50855,659,4771,2246,7480,7532,7529,1742,7476,4086,5522,6788,7472,1496,329,5500,595,1495,658,8322,23291,4088,7043	DLG1,PPP2R1A,SMAD2,ACTB,YWHAH,MYC,ID1,TGFBR2,SOX2,SAV1,CTNNB1,PPP2CB,BIRC5,SMAD4,FZD6,DVL2,DLG3,YWHAZ,FZD3,SNAI2,CSNK1E,TGFB2,PPP1CC,BMPR1A,CCND3,PARD6A,BMPR2,NF2,FGF1,WNT10B,YWHAG,YWHAB,DLG4,WNT7A,SMAD1,PPP2R2C,STK3,WNT2,CTNNA2,BIRC2,PPP1CB,CCND1,CTNNA1,BMPR1B,FZD4,FBXW11,SMAD3,TGFB3
ko00330	Arginine and proline metabolism	0.84437918105182	-0.169153618627148	49	14	0.00568412505075112	2463	7161	29920,1152,113451,51056,5831,4942,8974,4953,112483,2593,6303,384,55748,6723	PYCR2,CKB,AZIN2,LAP3,PYCR1,OAT,P4HA2,ODC1,SAT2,GAMT,SAT1,ARG2,CNDP2,SRM
hsa00330	Arginine and proline metabolism	0.84437918105182	-0.169153618627148	49	14	0.00568412505075112	2463	7161	113451,29920,1152,51056,5831,4942,2593,4953,8974,112483,6303,55748,384,6723	AZIN2,PYCR2,CKB,LAP3,PYCR1,OAT,GAMT,ODC1,P4HA2,SAT2,SAT1,CNDP2,ARG2,SRM
hsa00500	Starch and sucrose metabolism	0.844858091299978	-0.168586605018311	36	10	0.00406008932196508	2463	7161	5837,5834,283209,5236,2595,2632,2997,280,92579,7360	PYGM,PYGB,PGM2L1,PGM1,GANC,GBE1,GYS1,AMY2B,G6PC3,UGP2
ko05340	Primary immunodeficiency	0.844858091299978	-0.168586605018311	36	10	0.00406008932196508	2463	7161	5994,920,5896,8625,959,3561,29851,64421,5993,958	RFXAP,CD4,RAG1,RFXANK,CD40LG,IL2RG,ICOS,DCLRE1C,RFX5,CD40
hsa05340	Primary immunodeficiency	0.844858091299978	-0.168586605018311	36	10	0.00406008932196508	2463	7161	5896,920,5994,959,8625,3561,64421,29851,958,5993	RAG1,CD4,RFXAP,CD40LG,RFXANK,IL2RG,DCLRE1C,ICOS,CD40,RFX5
ko00500	Starch and sucrose metabolism	0.844858091299978	-0.168586605018311	36	10	0.00406008932196508	2463	7161	7360,280,2997,2595,2632,92579,5834,5837,5236,283209	UGP2,AMY2B,GYS1,GANC,GBE1,G6PC3,PYGB,PYGM,PGM1,PGM2L1
ko00590	Arachidonic acid metabolism	0.848042140755947	-0.164824950137281	62	18	0.00730816077953715	2463	7161	2880,5322,5730,11145,2877,10728,9536,1558,257202,11283,27306,100137049,1559,81579,874,2878,2882,2876	GPX5,PLA2G5,PTGDS,PLAAT3,GPX2,PTGES3,PTGES,CYP2C8,GPX6,CYP4F8,HPGDS,PLA2G4B,CYP2C9,PLA2G12A,CBR3,GPX3,GPX7,GPX1
hsa00590	Arachidonic acid metabolism	0.848042140755947	-0.164824950137281	62	18	0.00730816077953715	2463	7161	11283,27306,100137049,1559,81579,874,2878,2876,2882,2880,5322,11145,5730,2877,10728,9536,1558,257202	CYP4F8,HPGDS,PLA2G4B,CYP2C9,PLA2G12A,CBR3,GPX3,GPX1,GPX7,GPX5,PLA2G5,PLAAT3,PTGDS,GPX2,PTGES3,PTGES,CYP2C8,GPX6
hsa04930	Type II diabetes mellitus	0.849866245112404	-0.162676300571242	46	13	0.00527811611855461	2463	7161	5296,9021,5295,5290,122809,7124,8835,3767,5602,3551,8503,9370,5581	PIK3R2,SOCS3,PIK3R1,PIK3CA,SOCS4,TNF,SOCS2,KCNJ11,MAPK10,IKBKB,PIK3R3,ADIPOQ,PRKCE
ko04930	Type II diabetes mellitus	0.849866245112404	-0.162676300571242	46	13	0.00527811611855461	2463	7161	9021,5295,5296,9370,5581,8503,5602,3767,3551,5290,7124,8835,122809	SOCS3,PIK3R1,PIK3R2,ADIPOQ,PRKCE,PIK3R3,MAPK10,KCNJ11,IKBKB,PIK3CA,TNF,SOCS2,SOCS4
M00099	Sphingosine biosynthesis	0.855352279368155	-0.156241872250589	16	4	0.00162403572878603	2463	7161	2531,8560,253782,29956	KDSR,DEGS1,CERS6,CERS2
hsa_M00099	Sphingosine biosynthesis	0.855352279368155	-0.156241872250589	16	4	0.00162403572878603	2463	7161	2531,8560,253782,29956	KDSR,DEGS1,CERS6,CERS2
hsa03320	PPAR signaling pathway	0.856643817487825	-0.154733062309891	72	21	0.00852618757612668	2463	7161	3611,1376,4973,2182,1581,1962,1375,948,2712,2167,5106,2173,1593,2171,79966,6258,51,5468,9370,9415,5465	ILK,CPT2,OLR1,ACSL4,CYP7A1,EHHADH,CPT1B,CD36,GK2,FABP4,PCK2,FABP7,CYP27A1,FABP5,SCD5,RXRG,ACOX1,PPARG,ADIPOQ,FADS2,PPARA
ko03320	PPAR signaling pathway	0.856643817487825	-0.154733062309891	72	21	0.00852618757612668	2463	7161	51,5468,6258,9370,9415,5465,4973,1376,3611,1581,2182,5106,948,2167,2712,1962,1375,2171,79966,1593,2173	ACOX1,PPARG,RXRG,ADIPOQ,FADS2,PPARA,OLR1,CPT2,ILK,CYP7A1,ACSL4,PCK2,CD36,FABP4,GK2,EHHADH,CPT1B,FABP5,SCD5,CYP27A1,FABP7
hsa04080	Neuroactive ligand-receptor interaction	0.862276766404079	-0.148178985137191	276	87	0.0353227771010962	2463	7161	2894,2925,2690,2847,3953,1133,553,1141,1128,5028,5732,2831,2550,2911,4887,4987,2891,134,7433,2897,6870,11255,2859,2742,187,1131,2555,122042,2837,4889,1909,1812,140,6869,84539,9170,134864,2561,1139,2688,3274,10161,7253,27334,2890,3361,2741,1902,4986,5032,1132,3952,4886,1814,5737,3355,8698,2566,2554,3356,2918,5021,2562,153,1394,4829,148,3972,10888,2743,5340,706,1268,5734,4988,3350,5731,680,2147,1442,5030,2912,154,5617,319100,5644,155	GRID1,GRPR,GHR,MCHR1,LEPR,CHRM5,AVPR1B,CHRNB2,CHRM1,P2RY1,PTGER2,NPBWR1,GABBR1,GRM1,NPY2R,OPRL1,GRIA2,ADORA1,VIPR1,GRIK1,TACR3,HRH3,GPR35,GLRA2,APLNR,CHRM3,GABRA2,RXFP2,UTS2R,NPY5R,EDNRA,DRD1,ADORA3,TACR1,MCHR2,LPAR2,TAAR1,GABRB2,CHRNA7,GH1,HRH2,LPAR6,TSHR,P2RY10,GRIA1,HTR5A,GLRA1,LPAR1,OPRK1,P2RY11,CHRM4,LEP,NPY1R,DRD3,PTGFR,HTR1F,S1PR4,GABRG2,GABRA1,HTR2A,GRM8,OXTR,GABRB3,ADRB1,CRHR1,NMBR,ADRA1A,LHB,GPR83,GLRB,PLG,TSPO,CNR1,PTGER4,OPRM1,HTR1A,PTGER1,BRS3,F2,CSH1,P2RY4,GRM2,ADRB2,PRL,TAAR6,PRSS1,ADRB3
ko04080	Neuroactive ligand-receptor interaction	0.862276766404079	-0.148178985137191	276	87	0.0353227771010962	2463	7161	2555,2742,10161,1139,2688,9170,84539,6869,4889,1141,2847,2891,134,4987,4887,2550,2831,5734,1268,2743,10888,3972,4829,5644,5617,154,5030,1442,5737,1814,1902,3361,2741,7253,1394,3356,2554,2837,122042,1131,187,2859,11255,6870,2897,7433,3274,2561,134864,140,1909,1812,553,1133,3953,2690,2925,2894,2911,5732,5028,1128,4988,3350,706,5340,148,155,319100,2912,680,2147,5731,4886,1132,3952,5032,4986,2890,27334,153,2562,5021,2918,8698,2566,3355	GABRA2,GLRA2,LPAR6,CHRNA7,GH1,LPAR2,MCHR2,TACR1,NPY5R,CHRNB2,MCHR1,GRIA2,ADORA1,OPRL1,NPY2R,GABBR1,NPBWR1,PTGER4,CNR1,GLRB,GPR83,LHB,NMBR,PRSS1,PRL,ADRB2,P2RY4,CSH1,PTGFR,DRD3,LPAR1,HTR5A,GLRA1,TSHR,CRHR1,HTR2A,GABRA1,UTS2R,RXFP2,CHRM3,APLNR,GPR35,HRH3,TACR3,GRIK1,VIPR1,HRH2,GABRB2,TAAR1,ADORA3,EDNRA,DRD1,AVPR1B,CHRM5,LEPR,GHR,GRPR,GRID1,GRM1,PTGER2,P2RY1,CHRM1,OPRM1,HTR1A,TSPO,PLG,ADRA1A,ADRB3,TAAR6,GRM2,BRS3,F2,PTGER1,NPY1R,CHRM4,LEP,P2RY11,OPRK1,GRIA1,P2RY10,ADRB1,GABRB3,OXTR,GRM8,S1PR4,GABRG2,HTR1F
ko04742	Taste transduction	0.864944084506704	-0.145090416328435	82	24	0.0097442143727162	2463	7161	1131,2555,40,259286,3350,54429,5330,50837,50833,5153,50838,2784,51764,80834,259292,3355,5136,5028,5567,2554,5030,2911,259285,2550	CHRM3,GABRA2,ASIC2,TAS2R40,HTR1A,TAS2R5,PLCB2,TAS2R7,TAS2R16,PDE1B,TAS2R13,GNB3,GNG13,TAS1R2,TAS2R46,HTR1F,PDE1A,P2RY1,PRKACB,GABRA1,P2RY4,GRM1,TAS2R39,GABBR1
hsa04742	Taste transduction	0.864944084506704	-0.145090416328435	82	24	0.0097442143727162	2463	7161	2784,50838,51764,5567,5136,5028,3355,2550,2911,2554,259286,40,5330,50837,5153,259292,80834,259285,5030,1131,2555,54429,3350,50833	GNB3,TAS2R13,GNG13,PRKACB,PDE1A,P2RY1,HTR1F,GABBR1,GRM1,GABRA1,TAS2R40,ASIC2,PLCB2,TAS2R7,PDE1B,TAS2R46,TAS1R2,TAS2R39,P2RY4,CHRM3,GABRA2,TAS2R5,HTR1A,TAS2R16
M00135	GABA biosynthesis, eukaryotes, putrescine => GABA	0.87141422347647	-0.137637842874662	9	2	0.000812017864393017	2463	7161	6303,112483	SAT1,SAT2
hsa_M00135	GABA biosynthesis, eukaryotes, putrescine => GABA	0.87141422347647	-0.137637842874662	9	2	0.000812017864393017	2463	7161	112483,6303	SAT2,SAT1
hsa04340	Hedgehog signaling pathway	0.87176031184522	-0.137240764594451	47	13	0.00527811611855461	2463	7161	64399,1454,23291,51684,8405,339745,1456,122011,1452,57154,8452,5567,595	HHIP,CSNK1E,FBXW11,SUFU,SPOP,SPOPL,CSNK1G3,CSNK1A1L,CSNK1A1,SMURF1,CUL3,PRKACB,CCND1
ko04340	Hedgehog signaling pathway	0.87176031184522	-0.137240764594451	47	13	0.00527811611855461	2463	7161	1454,64399,339745,51684,23291,8405,1456,595,122011,1452,57154,5567,8452	CSNK1E,HHIP,SPOPL,SUFU,FBXW11,SPOP,CSNK1G3,CCND1,CSNK1A1L,CSNK1A1,SMURF1,PRKACB,CUL3
M00056	O-glycan biosynthesis, mucin type core	0.872617696915891	-0.136257737824555	27	7	0.00284206252537556	2463	7161	8693,2589,2590,79695,64409,9245,29071	GALNT4,GALNT1,GALNT2,GALNT12,GALNT17,GCNT3,C1GALT1C1
hsa_M00056	O-glycan biosynthesis, mucin type core	0.872617696915891	-0.136257737824555	27	7	0.00284206252537556	2463	7161	9245,64409,29071,79695,8693,2590,2589	GCNT3,GALNT17,C1GALT1C1,GALNT12,GALNT4,GALNT2,GALNT1
ko00040	Pentose and glucuronate interconversions	0.877803216138184	-0.130332837872578	34	9	0.00365408038976857	2463	7161	231,54658,6652,10327,7358,51084,7360,79799,6120	AKR1B1,UGT1A1,SORD,AKR1A1,UGDH,CRYL1,UGP2,UGT2A3,RPE
hsa00040	Pentose and glucuronate interconversions	0.877803216138184	-0.130332837872578	34	9	0.00365408038976857	2463	7161	10327,6652,54658,7358,51084,79799,6120,7360,231	AKR1A1,SORD,UGT1A1,UGDH,CRYL1,UGT2A3,RPE,UGP2,AKR1B1
ko00061	Fatty acid biosynthesis	0.878212043140293	-0.12986720751164	13	3	0.00121802679658952	2463	7161	27349,2182,31	MCAT,ACSL4,ACACA
hsa00061	Fatty acid biosynthesis	0.878212043140293	-0.12986720751164	13	3	0.00121802679658952	2463	7161	27349,2182,31	MCAT,ACSL4,ACACA
hsa_M00042	Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	1621	DBH
hsa00232	Caffeine metabolism	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	10	NAT2
M00042	Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	1621	DBH
hsa_M00057	Glycosaminoglycan biosynthesis, linkage tetrasaccharide	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	11285	B4GALT7
hsa_M00382	SCF-FBS complex	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	6500	SKP1
ko00232	Caffeine metabolism	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	10	NAT2
M00057	Glycosaminoglycan biosynthesis, linkage tetrasaccharide	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	11285	B4GALT7
hsa_M00044	Tyrosine degradation, tyrosine => homogentisate	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	2184	FAH
M00382	SCF-FBS complex	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	6500	SKP1
M00044	Tyrosine degradation, tyrosine => homogentisate	0.878555298149663	-0.129476427235082	5	1	0.000406008932196508	2463	7161	2184	FAH
ko04360	Axon guidance	0.883108399109134	-0.124307323614852	174	53	0.0215184734064149	2463	7161	998,5296,5295,2773,1947,3845,3611,1073,5781,1020,658,64101,2771,1944,57144,7220,659,8482,10500,50855,84628,5290,6387,6093,8503,818,5880,9037,7976,4233,10512,1072,4690,1969,5894,54910,9475,5062,3265,6714,1946,10154,2051,5535,59277,5530,7852,54961,56924,8829,2043,3897,5578	CDC42,PIK3R2,PIK3R1,GNAI3,EFNB1,KRAS,ILK,CFL2,PTPN11,CDK5,BMPR1B,LRRC4,GNAI2,EFNA3,PAK5,TRPC1,BMPR2,SEMA7A,SEMA6C,PARD6A,NTNG2,PIK3CA,CXCL12,ROCK1,PIK3R3,CAMK2G,RAC2,SEMA5A,FZD3,MET,SEMA3C,CFL1,NCK1,EPHA2,RAF1,SEMA4C,ROCK2,PAK2,HRAS,SRC,EFNA5,PLXNC1,EPHB6,PPP3R2,NTN4,PPP3CA,CXCR4,SSH3,PAK6,NRP1,EPHA4,L1CAM,PRKCA
hsa04360	Axon guidance	0.883108399109134	-0.124307323614852	174	53	0.0215184734064149	2463	7161	5781,1073,1020,658,998,5296,1947,2773,5295,3611,3845,50855,10500,8482,659,6093,5290,6387,84628,5880,818,8503,64101,1944,57144,2771,7220,1969,4690,1072,5894,5062,9475,54910,5535,2051,1946,10154,6714,3265,9037,10512,4233,7976,8829,3897,2043,5578,5530,59277,7852,56924,54961	PTPN11,CFL2,CDK5,BMPR1B,CDC42,PIK3R2,EFNB1,GNAI3,PIK3R1,ILK,KRAS,PARD6A,SEMA6C,SEMA7A,BMPR2,ROCK1,PIK3CA,CXCL12,NTNG2,RAC2,CAMK2G,PIK3R3,LRRC4,EFNA3,PAK5,GNAI2,TRPC1,EPHA2,NCK1,CFL1,RAF1,PAK2,ROCK2,SEMA4C,PPP3R2,EPHB6,EFNA5,PLXNC1,SRC,HRAS,SEMA5A,SEMA3C,MET,FZD3,NRP1,L1CAM,EPHA4,PRKCA,PPP3CA,NTN4,CXCR4,PAK6,SSH3
ko04810	Regulation of actin cytoskeleton	0.88314608213101	-0.12426465363464	211	65	0.026390580592773	2463	7161	2246,8503,5880,2255,6655,2252,2147,5290,6093,4659,57144,8074,3673,3693,8394,2258,7410,7074,2248,5500,1073,1399,10787,5295,3845,81,929,27006,1132,26999,5296,998,8822,9459,60,22808,55970,2260,22800,103910,8976,3696,10109,2257,54961,5604,1131,56924,10627,4478,9475,10094,5062,3265,6714,1072,1128,5894,3685,5501,79837,3655,1133,8823,7114	FGF1,PIK3R3,RAC2,FGF10,SOS2,FGF7,F2,PIK3CA,ROCK1,PPP1R12A,PAK5,FGF23,ITGA2,ITGB5,PIP5K1A,FGF13,VAV2,TIAM1,FGF3,PPP1CB,CFL2,CRKL,NCKAP1,PIK3R1,KRAS,ACTN4,CD14,FGF22,CHRM4,CYFIP2,PIK3R2,CDC42,FGF17,ARHGEF6,ACTB,MRAS,GNG12,FGFR1,RRAS2,MYL12B,WASL,ITGB8,ARPC2,FGF12,SSH3,MAP2K1,CHRM3,PAK6,MYL12A,MSN,ROCK2,ARPC3,PAK2,HRAS,SRC,CFL1,CHRM1,RAF1,ITGAV,PPP1CC,PIP4K2C,ITGA6,CHRM5,FGF16,TMSB4X
hsa04810	Regulation of actin cytoskeleton	0.88314608213101	-0.12426465363464	211	65	0.026390580592773	2463	7161	1131,56924,5604,54961,2257,3696,10109,4478,10627,2260,22800,55970,22808,60,8976,103910,1133,5501,79837,3655,3685,7114,8823,6714,3265,9475,5062,10094,1128,5894,1072,8074,57144,3693,3673,5880,8503,2246,5290,2147,2252,6093,4659,6655,2255,1132,3845,929,81,27006,5295,9459,26999,8822,5296,998,2248,7074,2258,7410,8394,10787,1399,5500,1073	CHRM3,PAK6,MAP2K1,SSH3,FGF12,ITGB8,ARPC2,MSN,MYL12A,FGFR1,RRAS2,GNG12,MRAS,ACTB,WASL,MYL12B,CHRM5,PPP1CC,PIP4K2C,ITGA6,ITGAV,TMSB4X,FGF16,SRC,HRAS,ROCK2,PAK2,ARPC3,CHRM1,RAF1,CFL1,FGF23,PAK5,ITGB5,ITGA2,RAC2,PIK3R3,FGF1,PIK3CA,F2,FGF7,ROCK1,PPP1R12A,SOS2,FGF10,CHRM4,KRAS,CD14,ACTN4,FGF22,PIK3R1,ARHGEF6,CYFIP2,FGF17,PIK3R2,CDC42,FGF3,TIAM1,FGF13,VAV2,PIP5K1A,NCKAP1,CRKL,PPP1CB,CFL2
ko04612	Antigen processing and presentation	0.886606639891509	-0.120353867536686	77	22	0.00893219650832318	2463	7161	2923,3458,8625,5721,1385,3326,5994,1508,5720,3822,6892,811,3824,5993,4800,7124,3312,4801,920,3309,3320,567	PDIA3,IFNG,RFXANK,PSME2,CREB1,HSP90AB1,RFXAP,CTSB,PSME1,KLRC2,TAPBP,CALR,KLRD1,RFX5,NFYA,TNF,HSPA8,NFYB,CD4,HSPA5,HSP90AA1,B2M
hsa04612	Antigen processing and presentation	0.886606639891509	-0.120353867536686	77	22	0.00893219650832318	2463	7161	567,811,3320,3822,5720,6892,920,5994,1508,3309,7124,3312,4801,3326,4800,1385,5993,5721,3824,2923,3458,8625	B2M,CALR,HSP90AA1,KLRC2,PSME1,TAPBP,CD4,RFXAP,CTSB,HSPA5,TNF,HSPA8,NFYB,HSP90AB1,NFYA,CREB1,RFX5,PSME2,KLRD1,PDIA3,IFNG,RFXANK
ko04020	Calcium signaling pathway	0.891302144970247	-0.115071801284637	181	55	0.022330491270808	2463	7161	5737,6786,3361,5330,6546,23236,153,5021,3356,952,7416,93129,5579,291,5350,148,5255,155,5153,818,154,493,5731,553,7125,1133,2767,56848,9630,2776,51806,109,2925,83447,5535,80228,2911,292,5136,1128,5567,5260,1131,108,5530,6870,3274,1139,7417,5257,10105,5578,6869,1909,1812	PTGFR,STIM1,HTR5A,PLCB2,SLC8A1,PLCB1,ADRB1,OXTR,HTR2A,CD38,VDAC1,ORAI3,PRKCB,SLC25A4,PLN,ADRA1A,PHKA1,ADRB3,PDE1B,CAMK2G,ADRB2,ATP2B4,PTGER1,AVPR1B,TNNC2,CHRM5,GNA11,SPHK2,GNA14,GNAQ,CALML5,ADCY3,GRPR,SLC25A31,PPP3R2,ORAI2,GRM1,SLC25A5,PDE1A,CHRM1,PRKACB,PHKG1,CHRM3,ADCY2,PPP3CA,TACR3,HRH2,CHRNA7,VDAC2,PHKB,PPIF,PRKCA,TACR1,EDNRA,DRD1
hsa04020	Calcium signaling pathway	0.891302144970247	-0.115071801284637	181	55	0.022330491270808	2463	7161	6870,5530,1131,108,5260,1909,1812,6869,5578,5257,7417,1139,3274,10105,2925,109,2776,51806,2767,1133,56848,9630,7125,553,5567,1128,5136,2911,292,5535,80228,83447,5350,291,5579,5255,148,93129,7416,952,5731,493,818,5153,154,155,6546,5330,3361,6786,5737,3356,23236,5021,153	TACR3,PPP3CA,CHRM3,ADCY2,PHKG1,EDNRA,DRD1,TACR1,PRKCA,PHKB,VDAC2,CHRNA7,HRH2,PPIF,GRPR,ADCY3,GNAQ,CALML5,GNA11,CHRM5,SPHK2,GNA14,TNNC2,AVPR1B,PRKACB,CHRM1,PDE1A,GRM1,SLC25A5,PPP3R2,ORAI2,SLC25A31,PLN,SLC25A4,PRKCB,PHKA1,ADRA1A,ORAI3,VDAC1,CD38,PTGER1,ATP2B4,CAMK2G,PDE1B,ADRB2,ADRB3,SLC8A1,PLCB2,HTR5A,STIM1,PTGFR,HTR2A,PLCB1,OXTR,ADRB1
hsa_M00427	Nuclear pore complex	0.89684257851826	-0.108874930074862	45	12	0.0048721071863581	2463	7161	79023,7329,23636,9972,7341,129401,6612,6613,6396,57122,11097,10762	NUP37,UBE2I,NUP62,NUP153,SUMO1,NUP35,SUMO3,SUMO2,SEC13,NUP107,NUP42,NUP50
M00427	Nuclear pore complex	0.89684257851826	-0.108874930074862	45	12	0.0048721071863581	2463	7161	129401,6613,6612,79023,7329,23636,9972,7341,11097,10762,6396,57122	NUP35,SUMO2,SUMO3,NUP37,UBE2I,NUP62,NUP153,SUMO1,NUP42,NUP50,SEC13,NUP107
M00688	MAPK (JNK) signaling	0.898213104904649	-0.107347928249399	21	5	0.00203004466098254	2463	7161	84451,4215,7786,5602,4296	MAP3K21,MAP3K3,MAP3K12,MAPK10,MAP3K11
hsa_M00688	MAPK (JNK) signaling	0.898213104904649	-0.107347928249399	21	5	0.00203004466098254	2463	7161	84451,4215,4296,7786,5602	MAP3K21,MAP3K3,MAP3K11,MAP3K12,MAPK10
hsa00250	Alanine, aspartate and glutamate metabolism	0.899062776201252	-0.106402418026027	35	9	0.00365408038976857	2463	7161	2572,443,57494,2752,159,2875,5471,284716,2673	GAD2,ASPA,RIMKLB,GLUL,ADSS2,GPT,PPAT,RIMKLA,GFPT1
ko00350	Tyrosine metabolism	0.899062776201252	-0.106402418026027	35	9	0.00365408038976857	2463	7161	2184,1621,124,125,4282,316,220,81889,1312	FAH,DBH,ADH1A,ADH1B,MIF,AOX1,ALDH1A3,FAHD1,COMT
ko00250	Alanine, aspartate and glutamate metabolism	0.899062776201252	-0.106402418026027	35	9	0.00365408038976857	2463	7161	57494,2752,159,2572,443,2673,2875,5471,284716	RIMKLB,GLUL,ADSS2,GAD2,ASPA,GFPT1,GPT,PPAT,RIMKLA
hsa00350	Tyrosine metabolism	0.899062776201252	-0.106402418026027	35	9	0.00365408038976857	2463	7161	1621,2184,124,220,4282,125,316,81889,1312	DBH,FAH,ADH1A,ALDH1A3,MIF,ADH1B,AOX1,FAHD1,COMT
ko00592	alpha-Linolenic acid metabolism	0.90790753616771	-0.0966127379805325	25	6	0.00243605359317905	2463	7161	100137049,11145,81579,9415,51,5322	PLA2G4B,PLAAT3,PLA2G12A,FADS2,ACOX1,PLA2G5
hsa00592	alpha-Linolenic acid metabolism	0.90790753616771	-0.0966127379805325	25	6	0.00243605359317905	2463	7161	81579,11145,100137049,5322,51,9415	PLA2G12A,PLAAT3,PLA2G4B,PLA2G5,ACOX1,FADS2
M00413	FA core complex	0.907948700658773	-0.0965673990486993	10	2	0.000812017864393017	2463	7161	2189,80233	FANCG,FAAP100
hsa_M00413	FA core complex	0.907948700658773	-0.0965673990486993	10	2	0.000812017864393017	2463	7161	2189,80233	FANCG,FAAP100
hsa01100	Metabolic pathways	0.910298646260971	-0.0939825506070418	1256	412	0.167275680064961	2463	7161	1353,2581,4952,3420,644,1592,2593,9489,8277,55907,8394,516,171568,4713,1351,51382,6480,10768,10063,539,4534,10476,4245,5106,51102,23600,29071,4711,8833,387787,54981,249,4698,3293,4357,5432,55753,1562,5834,11283,31,8898,4729,145226,5805,518,6120,10826,10905,534,1603,384,316,54107,84172,4694,4726,121278,5471,55349,38,3340,4706,113451,952,26289,55750,2203,10588,7357,1621,3290,29926,53,3419,79799,284098,7371,528,5160,440138,157506,11285,56848,166929,1327,3163,2729,8818,8708,1559,3028,51,280,139596,55790,6483,4710,3703,514,125,92579,9486,7385,6303,2590,27306,5279,10554,3074,220,7923,170712,10005,3945,10690,3631,11282,51084,8974,125965,85365,4720,498,10632,9215,8707,55224,10026,3157,1798,10621,259230,3030,441024,9245,90423,1629,50814,6309,54963,9249,1577,549,4716,35,27430,5558,140838,23193,7358,6240,51109,5438,4190,2752,54658,55703,5837,10007,2523,8693,8992,6390,5538,438,84701,81889,5631,6470,83539,5441,23646,5048,1339,2589,5050,6723,9791,7991,10993,64409,6391,1962,48,2875,231,56623,132789,55967,27349,4697,7360,5223,5425,10327,55902,4860,2595,3033,8733,54,6697,55163,10,51763,146664,1584,11145,1312,256435,30834,522,79695,1594,7263,8702,3145,5373,5096,10449,669,55278,57494,6675,23236,27089,253782,11019,6610,533,4594,66008,2531,1586,9348,10728,5230,29956,8692,493911,29954,54480,1841,1635,84992,513,2987,29880,5436,3073,5322,100137049,55326,26035,5049,79147,8789,1036,515,6484,2182,2026,2997,9107,124,55454,4718,81579,84265,1340,275,4507,23649,5330,4942,79077,523,2683,3417,51056,1585,4714,11041,204,4722,3620,8703,9331,84284,51477,2135,2572,10901,5831,5435,9536,1737,1589,443,1537,22845,5277,9377,11320,2530,5162,132,4597,1558,3292,29906,5433,2762,10975,134147,159,57678,2023,2131,1152,10678,29925,5431,2218,1349,51727,83594,83549,2673,6652,874,8790,1352,1581,506,29920,7264,1345,4953,9104,1593,4831,120227,51082,9550,7388,4712,2582,79178,22928,6307,5091,112483,8801,4833,3418,8560,6184,8705,9060,15,8630,4728,5236,50,7384,4144,51251,4830,2597,22929,92483,6482,2184,85007,3613,56655,9468,85465,2539,54928,646625,22978,9514,9453,84890,79586,57804,2712,9588,728635,7298,1120,22934,3939,55748,284716,2686,10243,7372,8869,5730,1543,4695,36,1743,2222,8706,2632,1633,10423	COX11,GALC,OCRL,IDH3B,BLVRA,CYP26A1,GAMT,PGS1,TKTL1,CMAS,PIP5K1A,ATP5MC1,POLR3H,NDUFB7,COX8A,ATP6V1D,ST6GAL1,AHCYL1,COX17,ATP5PO,MTM1,ATP5PD,MGAT1,PCK2,MECR,AMACR,C1GALT1C1,NDUFB5,GMPS,LIPT2,NMRK1,ALPL,NDUFA5,HSD17B3,MPST,POLR2C,OGDHL,CYP2C18,PYGB,CYP4F8,ACACA,MTMR2,NDUFV2,RDH12,PTS,ATP5MC3,RPE,FAXDC2,MAN1A2,ATP6V1G2,DAD1,ARG2,AOX1,POLE3,POLR1B,NDUFA1,NDUFS6,TPH2,PPAT,CHDH,ACAT1,NDST1,NDUFAB1,AZIN2,CD38,AK5,AGK,FBP1,MTHFS,UGCG,DBH,HSD11B1,GMPPA,ACP2,IDH3A,UGT2A3,PIGW,UCK2,ATP6V1C1,PDHA1,ALG11,RDH10,B4GALT7,SPHK2,SGMS2,COX4I1,HMOX2,GCLC,DPM2,B3GALT1,CYP2C9,HSD17B10,ACOX1,AMY2B,UPRT,CSGALNACT1,ST3GAL2,NDUFB4,STT3A,ATP5F1E,ADH1B,G6PC3,CHST10,UQCRC2,SAT1,GALNT2,HPGDS,PIGC,AGPAT1,HEXB,ALDH1A3,HSD17B8,COX7B2,ACOT8,LDHB,FUT9,INPP4A,MGAT4B,CRYL1,P4HA2,COX6B2,ALG2,NDUFS2,ATP5F1A,ATP5MG,LARGE1,B3GALT2,ETNK2,PIGK,HMGCS1,DPAGT1,POLR3F,SGMS1,HADHA,MTHFD2L,GCNT3,ATP6V1E2,DBT,NSDHL,SC5D,UCKL1,DHRS3,CYP3A5,AUH,NDUFB10,ACADS,MAT2B,PRIM2,NANP,GANAB,UGDH,RRM1,RDH11,POLR2I,MDH1,GLUL,UGT1A1,POLR3B,PYGM,GNPDA1,FUT1,GALNT4,ATP6V0E1,SDHB,PPT1,ASMT,COX4I2,FAHD1,PRPS1,SHMT1,CHST9,POLR2L,PLD3,PAFAH1B1,COX6A2,GALNT1,PAFAH1B3,SRM,PTDSS1,TUSC3,SDS,GALNT17,SDHC,EHHADH,ACO1,GPT,AKR1B1,INPP5E,GNPDA2,NDUFA12,MCAT,NDUFA4,UGP2,PGAM1,POLD2,AKR1A1,ACSS2,PNP,GANC,HADH,GPAA1,ACP5,SPR,PNPO,NAT2,INPP5K,MGAT5B,CYP11B1,PLAAT3,COMT,ST6GALNAC3,POLR1H,ATP5PF,GALNT12,CYP27B1,TST,B4GALT4,HMBS,PMM2,PCCB,ACAA2,BPGM,QRSL1,RIMKLB,UAP1,PLCB1,UQCRQ,CERS6,LIAS,SMPD2,ATP6V0B,MMUT,TRAK2,KDSR,CYP17A1,NDST3,PTGES3,PGK1,CERS2,HYAL2,PHOSPHO2,POMT2,CHPF2,DTYMK,DCTD,PIGY,ATP5F1D,GUK1,ALG5,POLR2G,HEXA,PLA2G5,PLA2G4B,AGPAT5,GLCE,PAFAH1B2,FKRP,FBP2,CDO1,ATP5PB,ST3GAL4,ACSL4,ENO2,GYS1,MTMR6,ADH1A,CSGALNACT2,NDUFC2,PLA2G12A,POLR3GL,COX6B1,AMT,MTAP,POLA2,PLCB2,OAT,DCTPP1,ATP6V1A,B4GALT1,IDH1,LAP3,CYP11B2,NDUFB8,B4GAT1,AK2,NDUFS3,IDO1,B4GALT3,B4GALT6,NTPCR,ISYNA1,EXTL2,GAD2,DHRS4,PYCR1,POLR2F,PTGES,DLAT,CYP21A2,ASPA,CYC1,DOLK,PIGA,COX5A,MGAT4A,FUT8,PDHB,ADK,MVD,CYP2C8,HSD17B1,ST8SIA5,POLR2D,GMDS,UQCR11,CMBL,ADSS2,GPAM,ENO1,EXT1,CKB,B3GNT2,GMPPB,POLR2B,FKTN,COX7B,CMPK1,NUDT12,UCK1,GFPT1,SORD,CBR3,FPGT,COX10,CYP7A1,ATP5F1B,PYCR2,GFUS,COX6C,ODC1,RGN,CYP27A1,NME2,CYP2R1,POLR1D,ATP6V1G1,UQCRH,NDUFB6,GALE,THTPA,SEPHS2,MSMO1,PC,SAT2,SUCLG2,NME4,IDH2,DEGS1,RPN1,B3GALT4,PAPSS2,AANAT,HSD17B6,NDUFS8,PGM1,ACO2,UQCRC1,MAT2A,NT5C3A,NME1,GAPDH,SEPHS1,LDHAL6B,ST3GAL1,FAH,PHYKPL,IMPA2,POLE4,PCYT1B,SELENOI,G6PD,BPNT2,URAD,NT5C2,GAL3ST1,GGPS1,ADO,CHPF,POLD4,GK2,PRDX6,DHRS4L1,TYMS,CHKB,RPIA,LDHA,CNDP2,RIMKLA,GGT7,GPHN,UMPS,ST3GAL5,PTGDS,CYP1A1,NDUFA2,ACADSB,DLST,FDFT1,B3GALNT1,GBE1,DCK,CDIPT
hsa00511	Other glycan degradation	0.914064119865189	-0.0898545569632243	18	4	0.00162403572878603	2463	7161	4758,175,3074,3073	NEU1,AGA,HEXB,HEXA
ko00511	Other glycan degradation	0.914064119865189	-0.0898545569632243	18	4	0.00162403572878603	2463	7161	3074,175,4758,3073	HEXB,AGA,NEU1,HEXA
hsa05414	Dilated cardiomyopathy	0.91685471530581	-0.0868062540588025	89	25	0.0101502233049127	2463	7161	109,6546,4000,1674,1605,7170,3655,3685,7139,7043,7042,5567,783,153,5350,3693,3673,10368,108,3696,7124,784,3479,785,60	ADCY3,SLC8A1,LMNA,DES,DAG1,TPM3,ITGA6,ITGAV,TNNT2,TGFB3,TGFB2,PRKACB,CACNB2,ADRB1,PLN,ITGB5,ITGA2,CACNG3,ADCY2,ITGB8,TNF,CACNB3,IGF1,CACNB4,ACTB
ko05414	Dilated cardiomyopathy	0.91685471530581	-0.0868062540588025	89	25	0.0101502233049127	2463	7161	1674,4000,1605,109,6546,3685,7043,7139,7042,7170,3655,783,5567,153,3693,3673,10368,5350,3696,108,3479,785,7124,784,60	DES,LMNA,DAG1,ADCY3,SLC8A1,ITGAV,TGFB3,TNNT2,TGFB2,TPM3,ITGA6,CACNB2,PRKACB,ADRB1,ITGB5,ITGA2,CACNG3,PLN,ITGB8,ADCY2,IGF1,CACNB4,TNF,CACNB3,ACTB
hsa00760	Nicotinate and nicotinamide metabolism	0.91685554190185	-0.0868053525030231	29	7	0.00284206252537556	2463	7161	952,4860,83594,54981,51251,316,22978	CD38,PNP,NUDT12,NMRK1,NT5C3A,AOX1,NT5C2
ko00760	Nicotinate and nicotinamide metabolism	0.91685554190185	-0.0868053525030231	29	7	0.00284206252537556	2463	7161	952,4860,83594,54981,51251,22978,316	CD38,PNP,NUDT12,NMRK1,NT5C3A,NT5C2,AOX1
hsa_M00048	Inosine monophosphate biosynthesis, PRPP + glutamine => IMP	0.920354948895631	-0.0829958693291509	6	1	0.000406008932196508	2463	7161	5471	PPAT
M00029	Urea cycle	0.920354948895631	-0.0829958693291509	6	1	0.000406008932196508	2463	7161	384	ARG2
M00048	Inosine monophosphate biosynthesis, PRPP + glutamine => IMP	0.920354948895631	-0.0829958693291509	6	1	0.000406008932196508	2463	7161	5471	PPAT
hsa_M00029	Urea cycle	0.920354948895631	-0.0829958693291509	6	1	0.000406008932196508	2463	7161	384	ARG2
ko05410	Hypertrophic cardiomyopathy (HCM)	0.922111162674162	-0.081089495801431	83	23	0.00933820544051969	2463	7161	7043,7139,3685,7042,7170,3655,4000,1674,1605,6546,783,3696,3693,3673,10368,60,5571,3479,3569,785,5564,784,7124	TGFB3,TNNT2,ITGAV,TGFB2,TPM3,ITGA6,LMNA,DES,DAG1,SLC8A1,CACNB2,ITGB8,ITGB5,ITGA2,CACNG3,ACTB,PRKAG1,IGF1,IL6,CACNB4,PRKAB1,CACNB3,TNF
hsa05410	Hypertrophic cardiomyopathy (HCM)	0.922111162674162	-0.081089495801431	83	23	0.00933820544051969	2463	7161	60,5564,784,7124,5571,3479,3569,785,3696,3693,10368,3673,783,7170,3655,7139,7043,3685,7042,6546,4000,1674,1605	ACTB,PRKAB1,CACNB3,TNF,PRKAG1,IGF1,IL6,CACNB4,ITGB8,ITGB5,CACNG3,ITGA2,CACNB2,TPM3,ITGA6,TNNT2,TGFB3,ITGAV,TGFB2,SLC8A1,LMNA,DES,DAG1
hsa04913	Ovarian steroidogenesis	0.922509807818621	-0.0806572713422688	50	13	0.00527811611855461	2463	7161	108,1543,1545,109,3292,3972,1586,3949,100137049,5567,3480,6770,3479	ADCY2,CYP1A1,CYP1B1,ADCY3,HSD17B1,LHB,CYP17A1,LDLR,PLA2G4B,PRKACB,IGF1R,STAR,IGF1
ko04913	Ovarian steroidogenesis	0.922509807818621	-0.0806572713422688	50	13	0.00527811611855461	2463	7161	3292,109,1586,3972,108,1545,1543,5567,3479,6770,3480,3949,100137049	HSD17B1,ADCY3,CYP17A1,LHB,ADCY2,CYP1B1,CYP1A1,PRKACB,IGF1,STAR,IGF1R,LDLR,PLA2G4B
ko05033	Nicotine addiction	0.925636550368708	-0.0772736155842275	40	10	0.00406008932196508	2463	7161	2554,2566,2890,1141,1139,2891,2561,2562,140679,2555	GABRA1,GABRG2,GRIA1,CHRNB2,CHRNA7,GRIA2,GABRB2,GABRB3,SLC32A1,GABRA2
hsa05033	Nicotine addiction	0.925636550368708	-0.0772736155842275	40	10	0.00406008932196508	2463	7161	2555,140679,2562,2561,1139,2891,1141,2890,2566,2554	GABRA2,SLC32A1,GABRB3,GABRB2,CHRNA7,GRIA2,CHRNB2,GRIA1,GABRG2,GABRA1
hsa05322	Systemic lupus erythematosus	0.929680847987345	-0.0729139259397347	132	38	0.0154283394234673	2463	7161	9555,94239,6634,8329,8335,221613,8348,3586,6737,958,3014,85236,158983,8350,942,474382,7124,940,8342,714,8345,81,6628,8331,92815,55506,255626,3458,941,3013,3015,8970,55766,2212,6632,959,8334,2209	MACROH2A1,H2AZ2,SNRPD3,H2AC13,H2AC4,H2AC1,H2BC17,IL10,TRIM21,CD40,H2AX,H2BC12,H2BW1,H3C1,CD86,H2AB1,TNF,CD28,H2BC14,C1QC,H2BC9,ACTN4,SNRPB,H2AC14,H2AC25,MACROH2A2,H2BC1,IFNG,CD80,H2AC7,H2AZ1,H2BC11,H2AJ,FCGR2A,SNRPD1,CD40LG,H2AC6,FCGR1A
ko05322	Systemic lupus erythematosus	0.929680847987345	-0.0729139259397347	132	38	0.0154283394234673	2463	7161	3586,958,6737,85236,3014,158983,8350,942,7124,474382,940,9555,94239,6634,8335,8329,221613,8348,55766,2212,959,6632,8334,2209,8342,714,8345,81,6628,8331,92815,55506,255626,3458,941,3013,3015,8970	IL10,CD40,TRIM21,H2BC12,H2AX,H2BW1,H3C1,CD86,TNF,H2AB1,CD28,MACROH2A1,H2AZ2,SNRPD3,H2AC4,H2AC13,H2AC1,H2BC17,H2AJ,FCGR2A,CD40LG,SNRPD1,H2AC6,FCGR1A,H2BC14,C1QC,H2BC9,ACTN4,SNRPB,H2AC14,H2AC25,MACROH2A2,H2BC1,IFNG,CD80,H2AC7,H2AZ1,H2BC11
ko00562	Inositol phosphate metabolism	0.933900077283278	-0.0683858301131988	71	19	0.00771416971173366	2463	7161	3636,5330,9107,4952,4534,5728,79837,3613,51477,3631,5294,5290,8898,51763,10423,56623,54928,8394,23236	INPPL1,PLCB2,MTMR6,OCRL,MTM1,PTEN,PIP4K2C,IMPA2,ISYNA1,INPP4A,PIK3CG,PIK3CA,MTMR2,INPP5K,CDIPT,INPP5E,BPNT2,PIP5K1A,PLCB1
hsa00562	Inositol phosphate metabolism	0.933900077283278	-0.0683858301131988	71	19	0.00771416971173366	2463	7161	5728,79837,3613,51477,3631,3636,5330,9107,4534,4952,56623,54928,8394,23236,5294,5290,8898,51763,10423	PTEN,PIP4K2C,IMPA2,ISYNA1,INPP4A,INPPL1,PLCB2,MTMR6,MTM1,OCRL,INPP5E,BPNT2,PIP5K1A,PLCB1,PIK3CG,PIK3CA,MTMR2,INPP5K,CDIPT
ko04330	Notch signaling pathway	0.939930300903617	-0.0619495544420605	48	12	0.0048721071863581	2463	7161	51107,171558,3516,5664,2033,23385,1856,1487,1387,5663,4853,55851	APH1A,PTCRA,RBPJ,PSEN2,EP300,NCSTN,DVL2,CTBP1,CREBBP,PSEN1,NOTCH2,PSENEN
hsa04330	Notch signaling pathway	0.939930300903617	-0.0619495544420605	48	12	0.0048721071863581	2463	7161	4853,171558,51107,5664,1487,1387,5663,55851,3516,2033,23385,1856	NOTCH2,PTCRA,APH1A,PSEN2,CTBP1,CREBBP,PSEN1,PSENEN,RBPJ,EP300,NCSTN,DVL2
hsa_M00014	Glucuronate pathway (uronate pathway)	0.942634504402217	-0.0590766596010296	27	6	0.00243605359317905	2463	7161	79799,51084,7358,10327,54658,6652	UGT2A3,CRYL1,UGDH,AKR1A1,UGT1A1,SORD
M00014	Glucuronate pathway (uronate pathway)	0.942634504402217	-0.0590766596010296	27	6	0.00243605359317905	2463	7161	7358,6652,54658,10327,79799,51084	UGDH,SORD,UGT1A1,AKR1A1,UGT2A3,CRYL1
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.943470898196407	-0.058189759168146	72	19	0.00771416971173366	2463	7161	1495,60,1496,783,785,784,3696,3685,1499,3655,2697,3693,4000,1674,1605,3673,3728,10368,6546	CTNNA1,ACTB,CTNNA2,CACNB2,CACNB4,CACNB3,ITGB8,ITGAV,CTNNB1,ITGA6,GJA1,ITGB5,LMNA,DES,DAG1,ITGA2,JUP,CACNG3,SLC8A1
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	0.943470898196407	-0.058189759168146	72	19	0.00771416971173366	2463	7161	3696,3685,1499,3655,3728,10368,3673,1605,2697,4000,1674,3693,6546,60,1495,785,783,1496,784	ITGB8,ITGAV,CTNNB1,ITGA6,JUP,CACNG3,ITGA2,DAG1,GJA1,LMNA,DES,ITGB5,SLC8A1,ACTB,CTNNA1,CACNB4,CACNB2,CTNNA2,CACNB3
ko00052	Galactose metabolism	0.947123752315505	-0.0543255160702506	31	7	0.00284206252537556	2463	7161	92579,2595,2582,7360,2683,231,5236	G6PC3,GANC,GALE,UGP2,B4GALT1,AKR1B1,PGM1
hsa00052	Galactose metabolism	0.947123752315505	-0.0543255160702506	31	7	0.00284206252537556	2463	7161	2582,5236,231,7360,2595,92579,2683	GALE,PGM1,AKR1B1,UGP2,GANC,G6PC3,B4GALT1
hsa_M00086	beta-Oxidation, acyl-CoA synthesis	0.947771547196712	-0.0536417897381308	7	1	0.000406008932196508	2463	7161	2182	ACSL4
M00086	beta-Oxidation, acyl-CoA synthesis	0.947771547196712	-0.0536417897381308	7	1	0.000406008932196508	2463	7161	2182	ACSL4
ko05231	Choline metabolism in cancer	0.948373452528766	-0.0530069170333972	99	27	0.0109622411693057	2463	7161	10810,5604,208,9468,3725,10000,5579,10434,8503,5880,5578,6009,6655,5290,8976,5295,2353,3845,5296,207,1120,8394,100137049,3265,6667,5602,5894	WASF3,MAP2K1,AKT2,PCYT1B,JUN,AKT3,PRKCB,LYPLA1,PIK3R3,RAC2,PRKCA,RHEB,SOS2,PIK3CA,WASL,PIK3R1,FOS,KRAS,PIK3R2,AKT1,CHKB,PIP5K1A,PLA2G4B,HRAS,SP1,MAPK10,RAF1
hsa05231	Choline metabolism in cancer	0.948373452528766	-0.0530069170333972	99	27	0.0109622411693057	2463	7161	5602,5894,100137049,8394,6667,3265,5296,207,1120,2353,5295,3845,5290,8976,6655,10434,5578,5880,6009,8503,10000,5579,10810,208,9468,3725,5604	MAPK10,RAF1,PLA2G4B,PIP5K1A,SP1,HRAS,PIK3R2,AKT1,CHKB,FOS,PIK3R1,KRAS,PIK3CA,WASL,SOS2,LYPLA1,PRKCA,RAC2,RHEB,PIK3R3,AKT3,PRKCB,WASF3,AKT2,PCYT1B,JUN,MAP2K1
M00683	Hippo signaling	0.950283374217418	-0.0509950502168515	16	3	0.00121802679658952	2463	7161	6788,4771,60485	STK3,NF2,SAV1
hsa_M00683	Hippo signaling	0.950283374217418	-0.0509950502168515	16	3	0.00121802679658952	2463	7161	6788,60485,4771	STK3,SAV1,NF2
ko04070	Phosphatidylinositol signaling system	0.956991408256258	-0.0439608653581378	97	26	0.0105562322371092	2463	7161	51806,5296,4952,5330,5295,5728,79837,90809,3631,51763,8898,9807,8394,23236,9107,4534,3636,5579,3613,10423,5290,55529,56623,54928,8503,5578	CALML5,PIK3R2,OCRL,PLCB2,PIK3R1,PTEN,PIP4K2C,PIP4P1,INPP4A,INPP5K,MTMR2,IP6K1,PIP5K1A,PLCB1,MTMR6,MTM1,INPPL1,PRKCB,IMPA2,CDIPT,PIK3CA,PIP4P2,INPP5E,BPNT2,PIK3R3,PRKCA
hsa04070	Phosphatidylinositol signaling system	0.956991408256258	-0.0439608653581378	97	26	0.0105562322371092	2463	7161	5290,55529,10423,5578,8503,54928,56623,5579,3636,4534,9107,3613,8898,51763,23236,8394,9807,5330,4952,51806,5296,3631,90809,79837,5728,5295	PIK3CA,PIP4P2,CDIPT,PRKCA,PIK3R3,BPNT2,INPP5E,PRKCB,INPPL1,MTM1,MTMR6,IMPA2,MTMR2,INPP5K,PLCB1,PIP5K1A,IP6K1,PLCB2,OCRL,CALML5,PIK3R2,INPP4A,PIP4P1,PIP4K2C,PTEN,PIK3R1
hsa04270	Vascular smooth muscle contraction	0.962801015280758	-0.0379085185653033	121	33	0.0133982947624848	2463	7161	5581,9475,100137049,23236,5567,5894,5588,2983,10268,5500,5501,5322,2767,10242,553,5330,109,51806,4882,2776,4637,5578,3778,81579,6093,4659,1909,5604,108,148,5579,59,3779	PRKCE,ROCK2,PLA2G4B,PLCB1,PRKACB,RAF1,PRKCQ,GUCY1B1,RAMP3,PPP1CB,PPP1CC,PLA2G5,GNA11,KCNMB2,AVPR1B,PLCB2,ADCY3,CALML5,NPR2,GNAQ,MYL6,PRKCA,KCNMA1,PLA2G12A,ROCK1,PPP1R12A,EDNRA,MAP2K1,ADCY2,ADRA1A,PRKCB,ACTA2,KCNMB1
ko04270	Vascular smooth muscle contraction	0.962801015280758	-0.0379085185653033	121	33	0.0133982947624848	2463	7161	108,5604,5579,148,3779,59,4637,5578,3778,81579,4659,6093,1909,2767,10242,5501,5322,553,5330,109,4882,2776,51806,100137049,9475,23236,5581,10268,2983,5567,5588,5894,5500	ADCY2,MAP2K1,PRKCB,ADRA1A,KCNMB1,ACTA2,MYL6,PRKCA,KCNMA1,PLA2G12A,PPP1R12A,ROCK1,EDNRA,GNA11,KCNMB2,PPP1CC,PLA2G5,AVPR1B,PLCB2,ADCY3,NPR2,GNAQ,CALML5,PLA2G4B,ROCK2,PLCB1,PRKCE,RAMP3,GUCY1B1,PRKACB,PRKCQ,RAF1,PPP1CB
hsa_M00001	Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	0.963554626431712	-0.0371260969053757	25	5	0.00203004466098254	2463	7161	5230,2026,5223,2023,2597	PGK1,ENO2,PGAM1,ENO1,GAPDH
M00001	Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate	0.963554626431712	-0.0371260969053757	25	5	0.00203004466098254	2463	7161	2597,5223,2023,5230,2026	GAPDH,PGAM1,ENO1,PGK1,ENO2
hsa00360	Phenylalanine metabolism	0.963621938038303	-0.0370562417526519	17	3	0.00121802679658952	2463	7161	4282,220,10249	MIF,ALDH1A3,GLYAT
ko00360	Phenylalanine metabolism	0.963621938038303	-0.0370562417526519	17	3	0.00121802679658952	2463	7161	4282,220,10249	MIF,ALDH1A3,GLYAT
hsa00591	Linoleic acid metabolism	0.965144113663049	-0.0354778482098755	29	6	0.00243605359317905	2463	7161	1558,1559,81579,11145,100137049,5322	CYP2C8,CYP2C9,PLA2G12A,PLAAT3,PLA2G4B,PLA2G5
ko00591	Linoleic acid metabolism	0.965144113663049	-0.0354778482098755	29	6	0.00243605359317905	2463	7161	5322,100137049,11145,81579,1559,1558	PLA2G5,PLA2G4B,PLAAT3,PLA2G12A,CYP2C9,CYP2C8
M00077	Chondroitin sulfate degradation	0.965752911371841	-0.0348472628176232	8	1	0.000406008932196508	2463	7161	8692	HYAL2
hsa_M00077	Chondroitin sulfate degradation	0.965752911371841	-0.0348472628176232	8	1	0.000406008932196508	2463	7161	8692	HYAL2
hsa_M00036	Leucine degradation, leucine => acetoacetate + acetyl-CoA	0.967517408519821	-0.0330218609379368	13	2	0.000812017864393017	2463	7161	1629,549	DBT,AUH
M00036	Leucine degradation, leucine => acetoacetate + acetyl-CoA	0.967517408519821	-0.0330218609379368	13	2	0.000812017864393017	2463	7161	549,1629	AUH,DBT
ko04142	Lysosome	0.97172164488051	-0.0286858891141642	123	33	0.0133982947624848	2463	7161	57192,53,3074,175,84572,5538,23659,9583,967,27074,533,10239,3988,3920,26503,23457,4758,8907,8763,1075,1508,10577,4891,1509,2581,8906,1513,3073,8905,5476,9741,54,9516	MCOLN1,ACP2,HEXB,AGA,GNPTG,PPT1,PLA2G15,ENTPD4,CD63,LAMP3,ATP6V0B,AP3S2,LIPA,LAMP2,SLC17A5,ABCB9,NEU1,AP1M1,CD164,CTSC,CTSB,NPC2,SLC11A2,CTSD,GALC,AP1G2,CTSK,HEXA,AP1S2,CTSA,LAPTM4A,ACP5,LITAF
hsa04142	Lysosome	0.97172164488051	-0.0286858891141642	123	33	0.0133982947624848	2463	7161	27074,9583,967,533,10239,26503,3920,23457,3988,53,57192,84572,5538,175,3074,23659,1509,2581,8906,10577,4891,3073,1513,8905,9741,5476,9516,54,4758,8907,1508,8763,1075	LAMP3,ENTPD4,CD63,ATP6V0B,AP3S2,SLC17A5,LAMP2,ABCB9,LIPA,ACP2,MCOLN1,GNPTG,PPT1,AGA,HEXB,PLA2G15,CTSD,GALC,AP1G2,NPC2,SLC11A2,HEXA,CTSK,AP1S2,LAPTM4A,CTSA,LITAF,ACP5,NEU1,AP1M1,CTSB,CD164,CTSC
hsa00565	Ether lipid metabolism	0.973712358199446	-0.0266393390789489	45	10	0.00406008932196508	2463	7161	9514,5050,23646,5048,85465,81579,100137049,11145,5322,5049	GAL3ST1,PAFAH1B3,PLD3,PAFAH1B1,SELENOI,PLA2G12A,PLA2G4B,PLAAT3,PLA2G5,PAFAH1B2
ko00565	Ether lipid metabolism	0.973712358199446	-0.0266393390789489	45	10	0.00406008932196508	2463	7161	5049,5322,100137049,11145,85465,81579,23646,5048,5050,9514	PAFAH1B2,PLA2G5,PLA2G4B,PLAAT3,SELENOI,PLA2G12A,PLD3,PAFAH1B1,PAFAH1B3,GAL3ST1
hsa_M00677	Wnt signaling	0.975782227369399	-0.0245158451610197	38	8	0.00324807145757207	2463	7161	7476,7976,7472,8322,1499,1856,8323,7480	WNT7A,FZD3,WNT2,FZD4,CTNNB1,DVL2,FZD6,WNT10B
M00677	Wnt signaling	0.975782227369399	-0.0245158451610197	38	8	0.00324807145757207	2463	7161	7476,7976,7472,7480,1499,8323,8322,1856	WNT7A,FZD3,WNT2,WNT10B,CTNNB1,FZD6,FZD4,DVL2
hsa_M00076	Dermatan sulfate degradation	0.97754524735942	-0.0227106993351708	9	1	0.000406008932196508	2463	7161	8692	HYAL2
M00076	Dermatan sulfate degradation	0.97754524735942	-0.0227106993351708	9	1	0.000406008932196508	2463	7161	8692	HYAL2
hsa00564	Glycerophospholipid metabolism	0.979130619405515	-0.0210902240996475	95	24	0.0097442143727162	2463	7161	9489,6901,23646,1120,10162,5322,55326,100137049,56985,11313,9468,55224,11145,57678,9791,23659,10423,8443,10554,2820,10434,85465,81579,43	PGS1,TAFAZZIN,PLD3,CHKB,LPCAT3,PLA2G5,AGPAT5,PLA2G4B,ADPRM,LYPLA2,PCYT1B,ETNK2,PLAAT3,GPAM,PTDSS1,PLA2G15,CDIPT,GNPAT,AGPAT1,GPD2,LYPLA1,SELENOI,PLA2G12A,ACHE
ko00564	Glycerophospholipid metabolism	0.979130619405515	-0.0210902240996475	95	24	0.0097442143727162	2463	7161	6901,9489,23646,1120,5322,10162,55326,100137049,56985,11313,55224,57678,11145,9791,9468,10423,8443,23659,10434,85465,81579,43,10554,2820	TAFAZZIN,PGS1,PLD3,CHKB,PLA2G5,LPCAT3,AGPAT5,PLA2G4B,ADPRM,LYPLA2,ETNK2,GPAM,PLAAT3,PTDSS1,PCYT1B,CDIPT,GNPAT,PLA2G15,LYPLA1,SELENOI,PLA2G12A,ACHE,AGPAT1,GPD2
ko00410	beta-Alanine metabolism	0.979281425031702	-0.0209362160328433	31	6	0.00243605359317905	2463	7161	2572,220,6723,1962,55748,3030	GAD2,ALDH1A3,SRM,EHHADH,CNDP2,HADHA
hsa00410	beta-Alanine metabolism	0.979281425031702	-0.0209362160328433	31	6	0.00243605359317905	2463	7161	2572,220,55748,1962,3030,6723	GAD2,ALDH1A3,CNDP2,EHHADH,HADHA,SRM
ko00531	Glycosaminoglycan degradation	0.980843852239564	-0.0193420041149729	19	3	0.00121802679658952	2463	7161	3073,8692,3074	HEXA,HYAL2,HEXB
hsa00531	Glycosaminoglycan degradation	0.980843852239564	-0.0193420041149729	19	3	0.00121802679658952	2463	7161	8692,3073,3074	HYAL2,HEXA,HEXB
ko00260	Glycine, serine and threonine metabolism	0.980971573621243	-0.0192117967772423	39	8	0.00324807145757207	2463	7161	669,10993,27232,55349,275,6470,2593,5223	BPGM,SDS,GNMT,CHDH,AMT,SHMT1,GAMT,PGAM1
hsa00260	Glycine, serine and threonine metabolism	0.980971573621243	-0.0192117967772423	39	8	0.00324807145757207	2463	7161	2593,5223,275,6470,10993,669,27232,55349	GAMT,PGAM1,AMT,SHMT1,SDS,BPGM,GNMT,CHDH
ko00340	Histidine metabolism	0.984727224091798	-0.0153906060182436	24	4	0.00162403572878603	2463	7161	55748,443,220,3176	CNDP2,ASPA,ALDH1A3,HNMT
hsa00340	Histidine metabolism	0.984727224091798	-0.0153906060182436	24	4	0.00162403572878603	2463	7161	220,55748,443,3176	ALDH1A3,CNDP2,ASPA,HNMT
ko00310	Lysine degradation	0.986587740009028	-0.013503016765863	59	13	0.00527811611855461	2463	7161	55753,80854,3030,51111,84193,38,85007,2145,3033,1743,2146,1962,6839	OGDHL,SETD7,HADHA,KMT5B,SETD3,ACAT1,PHYKPL,EZH1,HADH,DLST,EZH2,EHHADH,SUV39H1
hsa00310	Lysine degradation	0.986587740009028	-0.013503016765863	59	13	0.00527811611855461	2463	7161	84193,2145,85007,38,1743,3033,2146,6839,1962,55753,80854,3030,51111	SETD3,EZH1,PHYKPL,ACAT1,DLST,HADH,EZH2,SUV39H1,EHHADH,OGDHL,SETD7,HADHA,KMT5B
hsa04392	Hippo signaling pathway -multiple species	0.988104759816979	-0.0119665546518661	29	5	0.00203004466098254	2463	7161	83937,60485,4771,6788,1454	RASSF4,SAV1,NF2,STK3,CSNK1E
ko04392	Hippo signaling pathway -multiple species	0.988104759816979	-0.0119665546518661	29	5	0.00203004466098254	2463	7161	83937,6788,1454,4771,60485	RASSF4,STK3,CSNK1E,NF2,SAV1
ko00220	Arginine biosynthesis	0.990101163490285	-0.00994815573034575	21	3	0.00121802679658952	2463	7161	2752,2875,384	GLUL,GPT,ARG2
hsa00220	Arginine biosynthesis	0.990101163490285	-0.00994815573034575	21	3	0.00121802679658952	2463	7161	384,2875,2752	ARG2,GPT,GLUL
M00678	Hedgehog signaling	0.99034878864273	-0.00969808614038323	11	1	0.000406008932196508	2463	7161	51684	SUFU
hsa_M00678	Hedgehog signaling	0.99034878864273	-0.00969808614038323	11	1	0.000406008932196508	2463	7161	51684	SUFU
ko04610	Complement and coagulation cascades	0.991181145228313	-0.00885797101488237	79	18	0.00730816077953715	2463	7161	4179,7056,462,3053,5340,2158,1191,2155,714,7035,5627,2147,5265,966,5104,4153,7450,2159	CD46,THBD,SERPINC1,SERPIND1,PLG,F9,CLU,F7,C1QC,TFPI,PROS1,F2,SERPINA1,CD59,SERPINA5,MBL2,VWF,F10
hsa04610	Complement and coagulation cascades	0.991181145228313	-0.00885797101488237	79	18	0.00730816077953715	2463	7161	7035,714,2155,5627,7056,4179,1191,2158,5340,3053,462,4153,2159,7450,2147,5104,966,5265	TFPI,C1QC,F7,PROS1,THBD,CD46,CLU,F9,PLG,SERPIND1,SERPINC1,MBL2,F10,VWF,F2,SERPINA5,CD59,SERPINA1
M00089	Triacylglycerol biosynthesis	0.992394067503487	-0.00763500511113061	17	2	0.000812017864393017	2463	7161	57678,10554	GPAM,AGPAT1
hsa_M00089	Triacylglycerol biosynthesis	0.992394067503487	-0.00763500511113061	17	2	0.000812017864393017	2463	7161	57678,10554	GPAM,AGPAT1
M00130	Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	0.992927376430842	-0.00709775312927899	22	3	0.00121802679658952	2463	7161	5330,8394,23236	PLCB2,PIP5K1A,PLCB1
hsa_M00130	Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4	0.992927376430842	-0.00709775312927899	22	3	0.00121802679658952	2463	7161	8394,23236,5330	PIP5K1A,PLCB1,PLCB2
hsa05217	Basal cell carcinoma	0.993766377768135	-0.00625313237643541	55	11	0.00446609825416159	2463	7161	8323,8322,1856,7480,7157,7476,7976,51684,7472,1499,64399	FZD6,FZD4,DVL2,WNT10B,TP53,WNT7A,FZD3,SUFU,WNT2,CTNNB1,HHIP
ko05217	Basal cell carcinoma	0.993766377768135	-0.00625313237643541	55	11	0.00446609825416159	2463	7161	7472,64399,1499,7476,7157,51684,7976,7480,8323,8322,1856	WNT2,HHIP,CTNNB1,WNT7A,TP53,SUFU,FZD3,WNT10B,FZD6,FZD4,DVL2
ko00053	Ascorbate and aldarate metabolism	0.993988926470973	-0.00602921275887168	27	4	0.00162403572878603	2463	7161	9104,79799,54658,7358	RGN,UGT2A3,UGT1A1,UGDH
hsa00053	Ascorbate and aldarate metabolism	0.993988926470973	-0.00602921275887168	27	4	0.00162403572878603	2463	7161	7358,54658,79799,9104	UGDH,UGT1A1,UGT2A3,RGN
ko04974	Protein digestion and absorption	0.994985236310077	-0.00502737981294612	89	20	0.00812017864393017	2463	7161	5547,643847,1803,6546,478,6564,477,11136,23436,1278,54407,476,481,483,1281,5644,117247,23428,4311,6505	PRCP,PGA4,DPP4,SLC8A1,ATP1A3,SLC15A1,ATP1A2,SLC7A9,CELA3B,COL1A2,SLC38A2,ATP1A1,ATP1B1,ATP1B3,COL3A1,PRSS1,SLC16A10,SLC7A8,MME,SLC1A1
hsa04974	Protein digestion and absorption	0.994985236310077	-0.00502737981294612	89	20	0.00812017864393017	2463	7161	6564,478,643847,1803,6546,5547,23436,11136,477,1281,483,481,476,54407,1278,6505,23428,4311,117247,5644	SLC15A1,ATP1A3,PGA4,DPP4,SLC8A1,PRCP,CELA3B,SLC7A9,ATP1A2,COL3A1,ATP1B3,ATP1B1,ATP1A1,SLC38A2,COL1A2,SLC1A1,SLC7A8,MME,SLC16A10,PRSS1
hsa04744	Phototransduction	0.995629409593058	-0.00438016935783086	28	4	0.00162403572878603	2463	7161	5957,5145,51806,2782	RCVRN,PDE6A,CALML5,GNB1
ko04744	Phototransduction	0.995629409593058	-0.00438016935783086	28	4	0.00162403572878603	2463	7161	5957,2782,5145,51806	RCVRN,GNB1,PDE6A,CALML5
hsa00983	Drug metabolism - other enzymes	0.996865744799535	-0.00313917726565892	46	8	0.00324807145757207	2463	7161	54658,8833,7371,7372,79799,10,83549,54963	UGT1A1,GMPS,UCK2,UMPS,UGT2A3,NAT2,UCK1,UCKL1
ko00983	Drug metabolism - other enzymes	0.996865744799535	-0.00313917726565892	46	8	0.00324807145757207	2463	7161	7372,8833,7371,54658,79799,10,83549,54963	UMPS,GMPS,UCK2,UGT1A1,UGT2A3,NAT2,UCK1,UCKL1
ko00860	Porphyrin and chlorophyll metabolism	0.996934863300152	-0.00306984385251419	42	7	0.00284206252537556	2463	7161	3145,2395,54658,3163,644,79799,1352	HMBS,FXN,UGT1A1,HMOX2,BLVRA,UGT2A3,COX10
hsa00860	Porphyrin and chlorophyll metabolism	0.996934863300152	-0.00306984385251419	42	7	0.00284206252537556	2463	7161	79799,644,3145,2395,54658,3163,1352	UGT2A3,BLVRA,HMBS,FXN,UGT1A1,HMOX2,COX10
hsa05416	Viral myocarditis	0.996984287386896	-0.00302026903726965	58	11	0.00446609825416159	2463	7161	942,959,857,595,940,3383,5880,958,60,1605,941	CD86,CD40LG,CAV1,CCND1,CD28,ICAM1,RAC2,CD40,ACTB,DAG1,CD80
ko04512	ECM-receptor interaction	0.99777686956573	-0.00222560525731713	82	17	0.00690215184734064	2463	7161	2815,1278,6696,7450,7059,7143,948,961,3693,1605,3673,3913,3655,9899,3685,3696,6385	GP9,COL1A2,SPP1,VWF,THBS3,TNR,CD36,CD47,ITGB5,DAG1,ITGA2,LAMB2,ITGA6,SV2B,ITGAV,ITGB8,SDC4
hsa04512	ECM-receptor interaction	0.99777686956573	-0.00222560525731713	82	17	0.00690215184734064	2463	7161	961,948,1605,3673,3693,9899,3655,3913,3696,6385,3685,1278,2815,6696,7143,7059,7450	CD47,CD36,DAG1,ITGA2,ITGB5,SV2B,ITGA6,LAMB2,ITGB8,SDC4,ITGAV,COL1A2,GP9,SPP1,TNR,THBS3,VWF
ko04950	Maturity onset diabetes of the young	0.998217727416099	-0.0017838627213361	26	3	0.00121802679658952	2463	7161	6928,3171,5080	HNF1B,FOXA3,PAX6
hsa04950	Maturity onset diabetes of the young	0.998217727416099	-0.0017838627213361	26	3	0.00121802679658952	2463	7161	5080,6928,3171	PAX6,HNF1B,FOXA3
hsa03460	Fanconi anemia pathway	0.998924123823037	-0.00107645534718449	54	9	0.00365408038976857	2463	7161	8940,116028,548593,2189,80010,6119,80233,672,6118	TOP3B,RMI2,SLX1A,FANCG,RMI1,RPA3,FAAP100,BRCA1,RPA2
ko03460	Fanconi anemia pathway	0.998924123823037	-0.00107645534718449	54	9	0.00365408038976857	2463	7161	80233,672,6118,116028,8940,548593,80010,6119,2189	FAAP100,BRCA1,RPA2,RMI2,TOP3B,SLX1A,RMI1,RPA3,FANCG
ko05150	Staphylococcus aureus infection	0.999182826574097	-0.000817507494113691	55	9	0.00365408038976857	2463	7161	3383,2209,5340,2212,2213,2204,4153,3586,714	ICAM1,FCGR1A,PLG,FCGR2A,FCGR2B,FCAR,MBL2,IL10,C1QC
hsa05150	Staphylococcus aureus infection	0.999182826574097	-0.000817507494113691	55	9	0.00365408038976857	2463	7161	2213,2212,5340,3383,2209,714,4153,3586,2204	FCGR2B,FCGR2A,PLG,ICAM1,FCGR1A,C1QC,MBL2,IL10,FCAR
hsa_M00359	Aminoacyl-tRNA biosynthesis, eukaryotes	0.999244549081966	-0.00075573641487408	38	5	0.00203004466098254	2463	7161	3735,4141,2193,833,5917	KARS1,MARS1,FARSA,CARS1,RARS1
M00359	Aminoacyl-tRNA biosynthesis, eukaryotes	0.999244549081966	-0.00075573641487408	38	5	0.00203004466098254	2463	7161	4141,2193,3735,5917,833	MARS1,FARSA,KARS1,RARS1,CARS1
ko00770	Pantothenate and CoA biosynthesis	0.999498774252994	-0.000501351402619944	18	1	0.000406008932196508	2463	7161	60496	AASDHPPT
hsa00770	Pantothenate and CoA biosynthesis	0.999498774252994	-0.000501351402619944	18	1	0.000406008932196508	2463	7161	60496	AASDHPPT
hsa00970	Aminoacyl-tRNA biosynthesis	0.999526249251005	-0.000473863004336378	44	6	0.00243605359317905	2463	7161	3735,4141,55278,2193,5917,833	KARS1,MARS1,QRSL1,FARSA,RARS1,CARS1
ko02010	ABC transporters	0.999526249251005	-0.000473863004336378	44	6	0.00243605359317905	2463	7161	1244,9429,23457,10057,1080,5243	ABCC2,ABCG2,ABCB9,ABCC5,CFTR,ABCB1
hsa02010	ABC transporters	0.999526249251005	-0.000473863004336378	44	6	0.00243605359317905	2463	7161	1244,5243,10057,23457,9429,1080	ABCC2,ABCB1,ABCC5,ABCB9,ABCG2,CFTR
ko00970	Aminoacyl-tRNA biosynthesis	0.999526249251005	-0.000473863004336378	44	6	0.00243605359317905	2463	7161	4141,3735,833,5917,2193,55278	MARS1,KARS1,CARS1,RARS1,FARSA,QRSL1
ko04975	Fat digestion and absorption	0.999714486152962	-0.000285554613876242	41	5	0.00203004466098254	2463	7161	948,5322,10554,29881,81579	CD36,PLA2G5,AGPAT1,NPC1L1,PLA2G12A
hsa04975	Fat digestion and absorption	0.999714486152962	-0.000285554613876242	41	5	0.00203004466098254	2463	7161	81579,10554,29881,5322,948	PLA2G12A,AGPAT1,NPC1L1,PLA2G5,CD36
ko00561	Glycerolipid metabolism	0.99998256461054	-1.74355414585828e-05	59	7	0.00284206252537556	2463	7161	231,2712,10327,10554,55326,57678,55750	AKR1B1,GK2,AKR1A1,AGPAT1,AGPAT5,GPAM,AGK
hsa00561	Glycerolipid metabolism	0.99998256461054	-1.74355414585828e-05	59	7	0.00284206252537556	2463	7161	57678,55326,55750,10327,2712,231,10554	GPAM,AGPAT5,AGK,AKR1A1,GK2,AKR1B1,AGPAT1
hsa04740	Olfactory transduction	0.999999999833954	-1.66045688623275e-10	415	85	0.0345107592367032	2463	7161	6546,283297,219981,403253,219875,219437,26686,341418,125958,121364,26692,120775,134083,125963,26534,390436,390437,442186,442191,390157,390261,79544,26533,392138,219959,283162,4992,26648,441608,283694,81696,390260,26493,120787,442361,79290,390195,219954,818,5153,83988,390199,390433,401666,26339,109,119772,341152,441669,51806,219960,390648,7932,81285,2788,121130,441639,390162,26211,390152,441670,5567,5136,219983,10798,119765,390265,51764,2782,219858,138802,124538,219865,390431,120586,219870,338675,5997,5138,390059,390429,119692,219431,219986,390093	SLC8A1,OR10A4,OR5A2,OR4A47,OR4D5,OR5L1,OR4E2,OR6C4,OR7D4,OR10A7,OR2W1,OR2D3,OR2Y1,OR1M1,OR10G2,OR4K17,OR4N5,OR2J3,OR14J1,OR8K1,OR6M1,OR4K1,OR10G3,OR2A25,OR1S1,OR8B4,OR1F1,OR7E24,OR5B3,OR4N4,OR5V1,OR6X1,OR8B8,OR52W1,OR2A2,OR13A1,OR5AN1,OR9I1,CAMK2G,PDE1B,NCALD,OR4D9,OR4K13,OR51A4,OR5K1,ADCY3,OR52M1,OR2AT4,OR4Q3,CALML5,OR10Q1,OR4F6,OR2H2,OR51E2,GNG7,OR10P1,OR9K2,OR5M9,OR2F1,OR8H3,OR4M1,PRKACB,PDE1A,OR4D6,OR5I1,OR4B1,OR10G7,GNG13,GNB1,OR8B12,OR13C8,OR4D2,OR8G5,OR4K2,OR8I2,OR10G9,OR5AP2,RGS2,PDE2A,OR51M1,OR4N2,OR51S1,OR4S2,OR4D11,OR10A6
ko04740	Olfactory transduction	0.999999999833954	-1.66045688623275e-10	415	85	0.0345107592367032	2463	7161	109,119772,7932,390648,219960,51806,441669,341152,2788,81285,441639,121130,26211,390162,441670,390152,5136,5567,219983,10798,390265,119765,51764,2782,138802,219858,124538,390431,219865,120586,219870,338675,5997,5138,119692,219431,390429,390059,219986,390093,6546,283297,403253,219981,219875,121364,125958,26686,341418,219437,26692,120775,134083,125963,26534,390436,390437,79544,390261,390157,442191,442186,26533,392138,219959,283162,4992,26648,441608,283694,26493,390260,81696,120787,79290,442361,390195,219954,5153,83988,818,390199,401666,390433,26339	ADCY3,OR52M1,OR2H2,OR4F6,OR10Q1,CALML5,OR4Q3,OR2AT4,GNG7,OR51E2,OR9K2,OR10P1,OR2F1,OR5M9,OR4M1,OR8H3,PDE1A,PRKACB,OR4D6,OR5I1,OR10G7,OR4B1,GNG13,GNB1,OR13C8,OR8B12,OR4D2,OR4K2,OR8G5,OR8I2,OR10G9,OR5AP2,RGS2,PDE2A,OR51S1,OR4S2,OR4N2,OR51M1,OR4D11,OR10A6,SLC8A1,OR10A4,OR4A47,OR5A2,OR4D5,OR10A7,OR7D4,OR4E2,OR6C4,OR5L1,OR2W1,OR2D3,OR2Y1,OR1M1,OR10G2,OR4K17,OR4N5,OR4K1,OR6M1,OR8K1,OR14J1,OR2J3,OR10G3,OR2A25,OR1S1,OR8B4,OR1F1,OR7E24,OR5B3,OR4N4,OR8B8,OR6X1,OR5V1,OR52W1,OR13A1,OR2A2,OR5AN1,OR9I1,PDE1B,NCALD,CAMK2G,OR4D9,OR51A4,OR4K13,OR5K1
hsa00300	Lysine biosynthesis	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
hsa_M00294	DNA polymerase gamma complex	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
M00338	Cysteine biosynthesis, homocysteine + serine => cysteine	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
ko00300	Lysine biosynthesis	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
M00294	DNA polymerase gamma complex	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
hsa_M00338	Cysteine biosynthesis, homocysteine + serine => cysteine	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
M00554	Nucleotide sugar biosynthesis, galactose => UDP-galactose	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
hsa_M00106	Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
M00083	Fatty acid biosynthesis, elongation	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
hsa_M00083	Fatty acid biosynthesis, elongation	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
hsa_M00554	Nucleotide sugar biosynthesis, galactose => UDP-galactose	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
M00106	Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate	0.9999999999826	-1.73997205532572e-11	2	0	0	2463	7161
hsa_M00132	Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
M00046	Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
hsa_M00107	Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
hsa_M00020	Serine biosynthesis, glycerate-3P => serine	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
M00410	ESCRT-II complex	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
M00107	Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
hsa00780	Biotin metabolism	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
hsa_M00410	ESCRT-II complex	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
ko00780	Biotin metabolism	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
M00020	Serine biosynthesis, glycerate-3P => serine	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
M00132	Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
hsa_M00046	Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate	0.999999999990059	-9.94147125732425e-12	3	0	0	2463	7161
ko00471	D-Glutamine and D-glutamate metabolism	0.999999999994388	-5.61225892148354e-12	4	0	0	2463	7161
M00685	Apoptotic machinery	0.999999999994388	-5.61225892148354e-12	4	0	0	2463	7161
hsa_M00685	Apoptotic machinery	0.999999999994388	-5.61225892148354e-12	4	0	0	2463	7161
hsa00471	D-Glutamine and D-glutamate metabolism	0.999999999994388	-5.61225892148354e-12	4	0	0	2463	7161
hsa00524	Neomycin, kanamycin and gentamicin biosynthesis	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
hsa_M00128	Ubiquinone biosynthesis, eukaryotes, 4-hydroxybenzoate => ubiquinone	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
hsa00400	Phenylalanine, tyrosine and tryptophan biosynthesis	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
M00385	Cul4-DDB1-DDB2 complex	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
hsa_M00385	Cul4-DDB1-DDB2 complex	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
hsa_M00386	Cul4-DDB1-CSA complex	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
ko00400	Phenylalanine, tyrosine and tryptophan biosynthesis	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
ko00524	Neomycin, kanamycin and gentamicin biosynthesis	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
M00386	Cul4-DDB1-CSA complex	0.99999999999789	-2.10949660517379e-12	5	0	0	2463	7161
hsa_M00043	Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine	0.999999999998483	-1.51684220739412e-12	1	0	0	2463	7161
M00091	Phosphatidylcholine (PC) biosynthesis, PE => PC	0.999999999998483	-1.51684220739412e-12	1	0	0	2463	7161
hsa_M00091	Phosphatidylcholine (PC) biosynthesis, PE => PC	0.999999999998483	-1.51684220739412e-12	1	0	0	2463	7161
hsa00472	D-Arginine and D-ornithine metabolism	0.999999999998483	-1.51684220739412e-12	1	0	0	2463	7161
M00043	Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine	0.999999999998483	-1.51684220739412e-12	1	0	0	2463	7161
ko00472	D-Arginine and D-ornithine metabolism	0.999999999998483	-1.51684220739412e-12	1	0	0	2463	7161
hsa_M00691	DNA damage-induced cell cycle checkpoints	1.00000000000307	3.07197854394065e-12	7	0	0	2463	7161
M00691	DNA damage-induced cell cycle checkpoints	1.00000000000307	3.07197854394065e-12	7	0	0	2463	7161
hsa_M00120	Coenzyme A biosynthesis, pantothenate => CoA	1.00000000000307	3.07197854394065e-12	7	0	0	2463	7161
M00120	Coenzyme A biosynthesis, pantothenate => CoA	1.00000000000307	3.07197854394065e-12	7	0	0	2463	7161
hsa_M00078	Heparan sulfate degradation	1.00000000001014	1.01415794165338e-11	9	0	0	2463	7161
M00078	Heparan sulfate degradation	1.00000000001014	1.01415794165338e-11	9	0	0	2463	7161
hsa_M00424	Shelterin complex	1.00000000001086	1.08594762956299e-11	6	0	0	2463	7161
M00424	Shelterin complex	1.00000000001086	1.08594762956299e-11	6	0	0	2463	7161
hsa_M00098	Acylglycerol degradation	1.00000000001812	1.81173729515397e-11	11	0	0	2463	7161
M00098	Acylglycerol degradation	1.00000000001812	1.81173729515397e-11	11	0	0	2463	7161