TermID Term Enrichment logP Genes in Term Target Genes in Term Fraction of Targets in Term Total Target Genes Total Genes Entrez Gene IDs Gene Symbols HUMAN_DETOX1-PWY-1 reactive oxygen species degradation 0.00497234649991864 -5.3038634175128 10 8 0.0250783699059561 319 902 257202,2882,2876,6648,6647,6649,2877,2878 GPX6,GPX7,GPX1,SOD2,SOD1,SOD3,GPX2,GPX3 META_DETOX1-PWY-1 reactive oxygen species degradation 0.00930580790256592 -4.67711656809318 7 6 0.0188087774294671 319 902 2876,6647,6648,2878,2877,6649 GPX1,SOD1,SOD2,GPX3,GPX2,SOD3 META_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 0.0115564481589088 -4.46051171563924 9 7 0.0219435736677116 319 902 6240,1841,7298,4831,84284,1635,4830 RRM1,DTYMK,TYMS,NME2,NTPCR,DCTD,NME1 HUMAN_PWY-4081 glutathione redox reactions I 0.0230369661533219 -3.77065512919785 6 5 0.0156739811912226 319 902 2882,2877,2878,2879,2876 GPX7,GPX2,GPX3,GPX4,GPX1 HUMAN_PWY-4061 glutathione-mediated detoxification 0.0358861530825693 -3.32740376589879 19 11 0.0344827586206897 319 902 8836,2938,2941,2950,2948,2947,2949,373156,4259,2952,4258 GGH,GSTA1,GSTA4,GSTP1,GSTM4,GSTM3,GSTM5,GSTK1,MGST3,GSTT1,MGST2 HUMAN_PWY66-382 mineralocorticoid biosynthesis 0.0439646102343683 -3.12437028155227 3 3 0.00940438871473354 319 902 1584,1589,1585 CYP11B1,CYP21A2,CYP11B2 HUMAN_PWY66-381 glucocorticoid biosynthesis 0.0439646102343683 -3.12437028155227 3 3 0.00940438871473354 319 902 1584,1589,1586 CYP11B1,CYP21A2,CYP17A1 META_PWY66-382 mineralocorticoid biosynthesis 0.0439646102343683 -3.12437028155227 3 3 0.00940438871473354 319 902 1584,1589,1585 CYP11B1,CYP21A2,CYP11B2 META_PWY66-381 glucocorticoid biosynthesis 0.0439646102343683 -3.12437028155227 3 3 0.00940438871473354 319 902 1586,1589,1584 CYP17A1,CYP21A2,CYP11B1 META_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis I 0.0553873528133632 -2.89340399985815 9 6 0.0188087774294671 319 902 4831,84284,1841,4830,6240,7298 NME2,NTPCR,DTYMK,NME1,RRM1,TYMS META_PWY-4081 glutathione-peroxide redox reactions 0.0555848968218164 -2.88984375452179 5 4 0.0125391849529781 319 902 2877,2878,2879,2876 GPX2,GPX3,GPX4,GPX1 META_PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 0.0555848968218164 -2.88984375452179 5 4 0.0125391849529781 319 902 4831,1841,51727,4830 NME2,DTYMK,CMPK1,NME1 HUMAN_PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II 0.0573648617810259 -2.85832332719918 7 5 0.0156739811912226 319 902 6675,10007,2582,132789,64841 UAP1,GNPDA1,GALE,GNPDA2,GNPNAT1 META_PWY-7224 purine deoxyribonucleosides salvage 0.0573648617810259 -2.85832332719918 7 5 0.0156739811912226 319 902 4830,1633,4831,26289,2987 NME1,DCK,NME2,AK5,GUK1 HUMAN_PWY-7305 superpathway of steroid hormone biosynthesis 0.0875952952381718 -2.43502798980889 12 7 0.0219435736677116 319 902 3293,1585,1589,3292,1586,1584,51170 HSD17B3,CYP11B2,CYP21A2,HSD17B1,CYP17A1,CYP11B1,HSD17B11 META_PWY-6368 3-phosphoinositide degradation 0.0907946590728123 -2.3991548158889 19 10 0.0313479623824451 319 902 51763,5728,4952,90809,56623,3636,55529,22908,114971,3631 INPP5K,PTEN,OCRL,PIP4P1,INPP5E,INPPL1,PIP4P2,SACM1L,PTPMT1,INPP4A META_PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 0.0980893539887795 -2.32187644033055 10 6 0.0188087774294671 319 902 1633,51727,4830,4831,1841,7298 DCK,CMPK1,NME1,NME2,DTYMK,TYMS HUMAN_PWY-6567 chondroitin sulfate biosynthesis (late stages) 0.109361715232643 -2.21309440241143 8 5 0.0156739811912226 319 902 9435,10090,50515,166012,56548 CHST2,UST,CHST11,CHST13,CHST7 META_PWY-7229 superpathway of adenosine nucleotides de novo biosynthesis I 0.12068075816025 -2.11460658230921 6 4 0.0125391849529781 319 902 4831,26289,4830,6240 NME2,AK5,NME1,RRM1 HUMAN_PWY-6076 vitamin D3 biosynthesis 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 5447,1594 POR,CYP27B1 HUMAN_PWY-6370 ascorbate recycling (cytosolic) 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 2745,9446 GLRX,GSTO1 HUMAN_PWY-6260 thyroid hormone metabolism I (via deiodination) 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 1735,1734 DIO3,DIO2 META_PWY-6370 ascorbate recycling (cytosolic) 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 9446,2745 GSTO1,GLRX META_PWY-6076 vitamin D3 biosynthesis 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 120227,5447 CYP2R1,POR HUMAN_PWY-6566 chondroitin biosynthesis 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 55454,55790 CSGALNACT2,CSGALNACT1 META_PWY-6260 thyroid hormone metabolism I (via deiodination) 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 1735,1734 DIO3,DIO2 HUMAN_PWY-5481 lactate fermentation (reoxidation of cytosolic NADH) 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 3945,3939 LDHB,LDHA META_PWY-6688 thyronamine and iodothyronamine metabolism 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 1734,1735 DIO2,DIO3 HUMAN_PWY-6012-1 acyl carrier protein metabolism 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 60496,4706 AASDHPPT,NDUFAB1 HUMAN_PWY-5269 cardiolipin biosynthesis 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 4722,9489 NDUFS3,PGS1 HUMAN_PWY-6482 diphthamide biosynthesis 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 51611,89978 DPH5,DPH6 HUMAN_PWY-5905 hypusine biosynthesis 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 83475,1725 DOHH,DHPS HUMAN_PWY-6688 thyronamine and iodothyronamine metabolism 0.124820659971421 -2.08087729210501 2 2 0.00626959247648903 319 902 1734,1735 DIO2,DIO3 HUMAN_PWY-6368 3-phosphoinositide degradation 0.126488297168561 -2.0676054875956 20 10 0.0313479623824451 319 902 51763,5728,4952,23203,90809,56623,3636,55529,22908,3631 INPP5K,PTEN,OCRL,PMPCA,PIP4P1,INPP5E,INPPL1,PIP4P2,SACM1L,INPP4A META_POLYAMINSYN3-PWY superpathway of polyamine biosynthesis II 0.12949753937773 -2.04409339896724 4 3 0.00940438871473354 319 902 113451,6723,4953 AZIN2,SRM,ODC1 HUMAN_PWY-4261 glycerol degradation 0.12949753937773 -2.04409339896724 4 3 0.00940438871473354 319 902 256356,2712,2820 GK5,GK2,GPD2 META_PWY-7205 CMP phosphorylation 0.12949753937773 -2.04409339896724 4 3 0.00940438871473354 319 902 4830,51727,4831 NME1,CMPK1,NME2 HUMAN_THIOREDOX-PWY thioredoxin pathway 0.12949753937773 -2.04409339896724 4 3 0.00940438871473354 319 902 114112,7296,10587 TXNRD3,TXNRD1,TXNRD2 META_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA 0.12949753937773 -2.04409339896724 4 3 0.00940438871473354 319 902 1737,5162,5160 DLAT,PDHB,PDHA1 HUMAN_PWY-6117 spermine and spermidine degradation I 0.12949753937773 -2.04409339896724 4 3 0.00940438871473354 319 902 112483,196743,6303 SAT2,PAOX,SAT1 HUMAN_PWY-7112 4-hydroxy-2-nonenal detoxification 0.12949753937773 -2.04409339896724 4 3 0.00940438871473354 319 902 2950,2941,2938 GSTP1,GSTA4,GSTA1 META_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 0.133968576744669 -2.01015000843655 13 7 0.0219435736677116 319 902 6240,1841,7298,4830,51727,84284,4831 RRM1,DTYMK,TYMS,NME1,CMPK1,NTPCR,NME2 META_PWY66-409 superpathway of purine nucleotide salvage 0.133968576744669 -2.01015000843655 13 7 0.0219435736677116 319 902 26289,132,6240,4831,4830,2987,4860 AK5,ADK,RRM1,NME2,NME1,GUK1,PNP HUMAN_PWY-6569 chondroitin sulfate biosynthesis 0.165176037360158 -1.80074348071565 16 8 0.0250783699059561 319 902 55790,55454,11285,10090,50515,166012,56548,9435 CSGALNACT1,CSGALNACT2,B4GALT7,UST,CHST11,CHST13,CHST7,CHST2 META_PWY-7305 superpathway of steroid hormone biosynthesis 0.176829668257406 -1.73256833597081 9 5 0.0156739811912226 319 902 1589,1585,1584,3293,1586 CYP21A2,CYP11B2,CYP11B1,HSD17B3,CYP17A1 HUMAN_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 0.189865408591005 -1.66143983367518 14 7 0.0219435736677116 319 902 6240,1841,7298,4831,84284,4830,1635 RRM1,DTYMK,TYMS,NME2,NTPCR,NME1,DCTD META_PWY-6567 chondroitin sulfate biosynthesis (late stages) 0.205101953333455 -1.58424809013903 7 4 0.0125391849529781 319 902 10090,56548,166012,50515 UST,CHST7,CHST13,CHST11 HUMAN_PWY-6857 retinol biosynthesis 0.220354621055333 -1.51251711648071 17 8 0.0250783699059561 319 902 221223,83758,10901,157506,5948,9227,9249,51109 CES5A,RBP5,DHRS4,RDH10,RBP2,LRAT,DHRS3,RDH11 META_PWY-6111 mitochondrial L-carnitine shuttle 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 1375,1376,1384 CPT1B,CPT2,CRAT HUMAN_PWY-5966-1 fatty acid biosynthesis initiation 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 4706,27349,31 NDUFAB1,MCAT,ACACA HUMAN_UDPNACETYLGALSYN-PWY UDP-N-acetyl-D-glucosamine biosynthesis II 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 2673,6675,64841 GFPT1,UAP1,GNPNAT1 META_PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 1962,51,9415 EHHADH,ACOX1,FADS2 META_PWY-7726 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis (6-desaturase) 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 1962,51,9415 EHHADH,ACOX1,FADS2 META_PWY66-201 nicotine degradation IV 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 2328,316,11185 FMO3,AOX1,INMT META_PWY-6074 zymosterol biosynthesis 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 50814,6307,3930 NSDHL,MSMO1,LBR META_PWY-6566 chondroitin biosynthesis 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 79586,55790,55454 CHPF,CSGALNACT1,CSGALNACT2 HUMAN_PWY-6111 mitochondrial L-carnitine shuttle 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 1375,1384,1376 CPT1B,CRAT,CPT2 META_PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 4830,4831,6240 NME1,NME2,RRM1 HUMAN_PYRUVDEHYD-PWY pyruvate decarboxylation to acetyl CoA 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 5162,1737,5160 PDHB,DLAT,PDHA1 META_PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis I 0.240366503214571 -1.42559042373925 5 3 0.00940438871473354 319 902 6240,4831,4830 RRM1,NME2,NME1 META_PWY66-399 gluconeogenesis III 0.253315866362827 -1.37311808531472 15 7 0.0219435736677116 319 902 4190,92579,5091,5230,2026,2203,8789 MDH1,G6PC3,PC,PGK1,ENO2,FBP1,FBP2 HUMAN_PWY-6861 the visual cycle I (vertebrates) 0.253315866362827 -1.37311808531472 15 7 0.0219435736677116 319 902 83758,157506,10901,51109,9249,9227,5948 RBP5,RDH10,DHRS4,RDH11,DHRS3,LRAT,RBP2 HUMAN_PWY66-399 gluconeogenesis 0.253315866362827 -1.37311808531472 15 7 0.0219435736677116 319 902 2026,2203,8789,4190,92579,5230,5091 ENO2,FBP1,FBP2,MDH1,G6PC3,PGK1,PC META_PWY-6569 chondroitin sulfate biosynthesis 0.281194465088969 -1.26870880242224 18 8 0.0250783699059561 319 902 10090,55454,11285,79586,55790,166012,56548,50515 UST,CSGALNACT2,B4GALT7,CHPF,CSGALNACT1,CHST13,CHST7,CHST11 META_PWY-7527 L-methionine salvage cycle III 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 6723,4507 SRM,MTAP HUMAN_METHIONINE-DEG1-PWY methionine degradation 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 4144,27430 MAT2A,MAT2B HUMAN_NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 6120,22934 RPE,RPIA META_PWY-7466 acetone degradation III (to propane-1,2-diol) 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 231,125 AKR1B1,ADH1B HUMAN_PWY-5331 taurine biosynthesis 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 84890,1036 ADO,CDO1 HUMAN_PWY-4202 arsenate detoxification I (glutaredoxin) 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 4860,9446 PNP,GSTO1 HUMAN_PWY-7193 pyrimidine ribonucleosides salvage I 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 7371,83549 UCK2,UCK1 META_PWY-7193 pyrimidine ribonucleosides salvage I 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 7371,83549 UCK2,UCK1 META_PWY66-21 ethanol degradation II 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 55902,125 ACSS2,ADH1B HUMAN_SAM-PWY S-adenosyl-L-methionine biosynthesis 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 4144,27430 MAT2A,MAT2B HUMAN_GLUAMCAT-PWY N-acetylglucosamine degradation I 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 132789,10007 GNPDA2,GNPDA1 META_PWY-5664 tetrahydrobiopterin biosynthesis II 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 5805,6697 PTS,SPR HUMAN_PWY-5663 tetrahydrobiopterin de novo biosynthesis 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 5805,6697 PTS,SPR META_PWY-5331 taurine biosynthesis 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 84890,1036 ADO,CDO1 META_ARGASEDEG-PWY L-arginine degradation I (arginase pathway) 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 384,4942 ARG2,OAT META_PWY-2301 myo-inositol biosynthesis 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 3613,54928 IMPA2,BPNT2 META_PWY-4202 arsenate detoxification I (glutaredoxin) 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 4860,9446 PNP,GSTO1 META_PWY-5451 acetone degradation I (to methylglyoxal) 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 231,125 AKR1B1,ADH1B HUMAN_PWY-6608 guanosine nucleotides degradation 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 22978,4860 NT5C2,PNP META_PWY-5663 tetrahydrobiopterin biosynthesis I 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 6697,5805 SPR,PTS META_PWY66-425 L-lysine degradation II (L-pipecolate pathway) 0.286532759444938 -1.24990240575173 3 2 0.00626959247648903 319 902 1428,5831 CRYM,PYCR1 META_PWY-841 superpathway of purine nucleotides de novo biosynthesis I 0.292729865917791 -1.22850505455592 13 6 0.0188087774294671 319 902 4830,5471,4831,26289,6240,2987 NME1,PPAT,NME2,AK5,RRM1,GUK1 META_PWY-7228 superpathway of guanosine nucleotides de novo biosynthesis I 0.300842191435091 -1.20116943266311 8 4 0.0125391849529781 319 902 4831,4830,6240,2987 NME2,NME1,RRM1,GUK1 HUMAN_PWY-7434 terminal O-glycans residues modification 0.300842191435091 -1.20116943266311 8 4 0.0125391849529781 319 902 9245,8703,11041,10690 GCNT3,B4GALT3,B4GAT1,FUT9 META_PWY66-398 TCA cycle III (animals) 0.321869066698672 -1.13361044129156 16 7 0.0219435736677116 319 902 50,6390,3419,8801,6391,4190,1743 ACO2,SDHB,IDH3A,SUCLG2,SDHC,MDH1,DLST HUMAN_PWY66-398 TCA cycle 0.321869066698672 -1.13361044129156 16 7 0.0219435736677116 319 902 50,6390,3419,6391,8801,4190,1743 ACO2,SDHB,IDH3A,SDHC,SUCLG2,MDH1,DLST HUMAN_PWY-7224 purine deoxyribonucleosides salvage 0.340607167967044 -1.07702546585742 11 5 0.0156739811912226 319 902 2987,4830,1633,26289,4831 GUK1,NME1,DCK,AK5,NME2 META_PWY66-4 cholesterol biosynthesis III (via desmosterol) 0.340607167967044 -1.07702546585742 11 5 0.0156739811912226 319 902 50814,6307,3930,2222,6309 NSDHL,MSMO1,LBR,FDFT1,SC5D META_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 0.340607167967044 -1.07702546585742 11 5 0.0156739811912226 319 902 3930,2222,6307,6309,50814 LBR,FDFT1,MSMO1,SC5D,NSDHL META_PWY66-341 cholesterol biosynthesis I 0.340607167967044 -1.07702546585742 11 5 0.0156739811912226 319 902 6307,2222,3930,6309,50814 MSMO1,FDFT1,LBR,SC5D,NSDHL HUMAN_PWY-7219 adenosine ribonucleotides de novo biosynthesis 0.345725743510058 -1.06210946705145 19 8 0.0250783699059561 319 902 204,10632,159,26289,10476,498,506,513 AK2,ATP5MG,ADSS2,AK5,ATP5PD,ATP5F1A,ATP5F1B,ATP5F1D HUMAN_PWY-6558 heparan sulfate biosynthesis (late stages) 0.345725743510058 -1.06210946705145 19 8 0.0250783699059561 319 902 2131,9957,26035,9955,3340,9348,222537,2135 EXT1,HS3ST1,GLCE,HS3ST3A1,NDST1,NDST3,HS3ST5,EXTL2 HUMAN_PWY66-409 superpathway of purine nucleotide salvage 0.351720793264677 -1.04491761908699 38 15 0.0470219435736677 319 902 498,4830,2987,10476,506,4860,513,4831,8833,132,204,6240,159,26289,10632 ATP5F1A,NME1,GUK1,ATP5PD,ATP5F1B,PNP,ATP5F1D,NME2,GMPS,ADK,AK2,RRM1,ADSS2,AK5,ATP5MG META_PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 9415 FADS2 META_PWY-5512 UDP-N-acetyl-D-galactosamine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2582 GALE HUMAN_PWY-5120 geranylgeranyldiphosphate biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 9453 GGPS1 META_PWY-5120 geranylgeranyl diphosphate biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 9453 GGPS1 META_GLYCGREAT-PWY creatine biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2593 GAMT META_PWY-7625 phosphatidylinositol biosynthesis II (eukaryotes) 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 10423 CDIPT META_PWY-7344 UDP-D-galactose biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2582 GALE META_PWY-46 putrescine biosynthesis III 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 4953 ODC1 META_PWY-6241 thyroid hormone biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 1509 CTSD HUMAN_PWY-6502 oxidized GTP and dGTP detoxification 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 4521 NUDT1 HUMAN_PWY-5512 UDP-N-acetyl-D-galactosamine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2582 GALE META_PWY-5269 cardiolipin biosynthesis II 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 9489 PGS1 META_PWY-6012-1 acyl carrier protein activation 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 60496 AASDHPPT HUMAN_PWY-7501 phosphatidylserine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 9791 PTDSS1 HUMAN_PWY-46 putrescine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 4953 ODC1 META_PWY-6502 oxidized GTP and dGTP detoxification 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 4521 NUDT1 HUMAN_ALANINE-DEG3-PWY alanine biosynthesis/degradation 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2875 GPT HUMAN_PWY-4101 sorbitol degradation I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 6652 SORD HUMAN_GLNSYN-PWY glutamine biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2752 GLUL META_PWY-6619 adenine and adenosine salvage VI 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 132 ADK HUMAN_PWY66-11 BMP Signalling Pathway 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 4089 SMAD4 HUMAN_BSUBPOLYAMSYN-PWY spermidine biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 6723 SRM META_GLNSYN-PWY L-glutamine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2752 GLUL HUMAN_PWY-40 putrescine biosynthesis II 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 113451 AZIN2 META_PWY-6756 S-methyl-5'-thioadenosine degradation II 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 4507 MTAP META_ALANINE-SYN2-PWY L-alanine biosynthesis II 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2875 GPT META_PWY-5905 hypusine biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 83475 DOHH META_BSUBPOLYAMSYN-PWY spermidine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 6723 SRM META_PWY-7501 phosphatidylserine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 9791 PTDSS1 HUMAN_GLYCGREAT-PWY creatine biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2593 GAMT META_PWY-7435 mucin core 3 and core 4 O-glycosylation 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2589 GALNT1 META_PWY-7112 4-hydroxy-2-nonenal detoxification 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2938 GSTA1 META_PWY0-1313 acetate conversion to acetyl-CoA 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 55902 ACSS2 HUMAN_PWY-6756 S-methyl-5'-thioadenosine degradation 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 4507 MTAP META_ALANINE-DEG3-PWY L-alanine degradation III 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2875 GPT HUMAN_PWY-6334 L-dopa degradation 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 1312 COMT HUMAN_PWY0-1305 glutamate dependent acid resistance 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 2752 GLUL META_PWY-7219 adenosine ribonucleotides de novo biosynthesis 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 26289 AK5 HUMAN_PWY-6619 adenine and adenosine salvage II 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 132 ADK META_PWY-40 putrescine biosynthesis I 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 113451 AZIN2 HUMAN_PWY-2161B glutamate removal from folates 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 8836 GGH HUMAN_PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 0.353658536585554 -1.03942341727725 1 1 0.00313479623824451 319 902 7264 GFUS HUMAN_PENTOSE-P-PWY pentose phosphate pathway 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 22934,6120,2539 RPIA,RPE,G6PD META_PWY-7221 guanosine ribonucleotides de novo biosynthesis 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 4830,4831,2987 NME1,NME2,GUK1 META_ILEUDEG-PWY L-isoleucine degradation I 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 1629,3028,38 DBT,HSD17B10,ACAT1 META_PWY-7176 UTP and CTP de novo biosynthesis 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 4831,51727,4830 NME2,CMPK1,NME1 META_PWY-7277 sphingolipid biosynthesis (mammals) 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 171546,2531,8560 SPTSSA,KDSR,DEGS1 META_PWY-5327 superpathway of L-lysine degradation 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 35,1428,38 ACADS,CRYM,ACAT1 META_PWY3DJ-12 ceramide de novo biosynthesis 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 8560,2531,171546 DEGS1,KDSR,SPTSSA HUMAN_PWY-6074 zymosterol biosynthesis 0.360052248270067 -1.02150612397939 6 3 0.00940438871473354 319 902 50814,3930,6307 NSDHL,LBR,MSMO1 HUMAN_PWY-7184 pyrimidine deoxyribonucleotides de novo biosynthesis 0.369878208913521 -0.994581492629181 14 6 0.0188087774294671 319 902 1841,6240,4830,4831,84284,7298 DTYMK,RRM1,NME1,NME2,NTPCR,TYMS META_PWY-6558 heparan sulfate biosynthesis (late stages) 0.392929178649911 -0.934125890349791 17 7 0.0219435736677116 319 902 9957,2131,3340,9348,26035,9955,2135 HS3ST1,EXT1,NDST1,NDST3,GLCE,HS3ST3A1,EXTL2 HUMAN_PWY-7527 methionine salvage cycle III 0.400052209978273 -0.916160215446112 9 4 0.0125391849529781 319 902 27430,4144,6723,4507 MAT2B,MAT2A,SRM,MTAP HUMAN_PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis 0.411913543989465 -0.886941796338852 20 8 0.0250783699059561 319 902 7298,4831,84284,4830,51727,7372,6240,1841 TYMS,NME2,NTPCR,NME1,CMPK1,UMPS,RRM1,DTYMK META_PWY-6857 retinol biosynthesis 0.427144127401812 -0.850633787806745 12 5 0.0156739811912226 319 902 157506,51109,9249,5948,9227 RDH10,RDH11,DHRS3,RBP2,LRAT HUMAN_ILEUDEG-PWY isoleucine degradation 0.427144127401812 -0.850633787806745 12 5 0.0156739811912226 319 902 38,3030,36,3028,1629 ACAT1,HADHA,ACADSB,HSD17B10,DBT META_PWY66-5 superpathway of cholesterol biosynthesis 0.428053882695065 -0.848506197176995 23 9 0.0282131661442006 319 902 50814,4597,6309,2222,6307,3157,38,9453,3930 NSDHL,MVD,SC5D,FDFT1,MSMO1,HMGCS1,ACAT1,GGPS1,LBR HUMAN_PWY-841 purine nucleotides de novo biosynthesis 0.436107828998029 -0.829865751994558 37 14 0.0438871473354232 319 902 26289,159,10632,8833,204,6240,4831,513,10476,2987,506,5471,4830,498 AK5,ADSS2,ATP5MG,GMPS,AK2,RRM1,NME2,ATP5F1D,ATP5PD,GUK1,ATP5F1B,PPAT,NME1,ATP5F1A HUMAN_PWY-6292 cysteine biosynthesis 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 27430,4144 MAT2B,MAT2A HUMAN_PWY-6030 serotonin and melatonin biosynthesis 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 15,121278 AANAT,TPH2 META_PWY-6030 serotonin and melatonin biosynthesis 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 15,121278 AANAT,TPH2 META_PWY-5067 glycogen biosynthesis II (from UDP-D-Glucose) 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 2632,2997 GBE1,GYS1 HUMAN_PWY66-380 estradiol biosynthesis I 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 51170,3292 HSD17B11,HSD17B1 HUMAN_PWY-5659 GDP-mannose biosynthesis 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 5373,29926 PMM2,GMPPA HUMAN_PWY66-21 ethanol degradation II 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 125,55902 ADH1B,ACSS2 META_PWY66-368 ketolysis 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 5019,38 OXCT1,ACAT1 META_PWY-3781 aerobic respiration I (cytochrome c) 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 6390,6391 SDHB,SDHC HUMAN_PWY-6517 N-acetylglucosamine degradation II 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 10007,132789 GNPDA1,GNPDA2 HUMAN_ASPARAGINE-DEG1-PWY-1 asparagine degradation 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 80150,175 ASRGL1,AGA HUMAN_PWY-5874 heme degradation 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 3163,644 HMOX2,BLVRA HUMAN_PWY66-425 lysine degradation II (pipecolate pathway) 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 5831,1428 PYCR1,CRYM META_PWY-6061 bile acid biosynthesis, neutral pathway 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 1581,5447 CYP7A1,POR HUMAN_PWY66-368 ketolysis 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 5019,38 OXCT1,ACAT1 META_PWY-6608 guanosine nucleotides degradation III 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 22978,4860 NT5C2,PNP META_PWY-7434 terminal O-glycans residues modification 0.44356797951726 -0.812904209345571 4 2 0.00626959247648903 319 902 10690,11041 FUT9,B4GAT1 HUMAN_PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 0.447586437281602 -0.803885603982892 15 6 0.0188087774294671 319 902 1841,1633,4830,51727,4831,7298 DTYMK,DCK,NME1,CMPK1,NME2,TYMS META_PWY66-374 C20 prostanoid biosynthesis 0.47626496947412 -0.741780921068545 7 3 0.00940438871473354 319 902 10728,27306,5730 PTGES3,HPGDS,PTGDS META_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 0.47626496947412 -0.741780921068545 7 3 0.00940438871473354 319 902 4831,4830,51727 NME2,NME1,CMPK1 HUMAN_PWY66-374 C20 prostanoid biosynthesis 0.47626496947412 -0.741780921068545 7 3 0.00940438871473354 319 902 27306,10728,5730 HPGDS,PTGES3,PTGDS HUMAN_PWY-5067 glycogen biosynthesis 0.47626496947412 -0.741780921068545 7 3 0.00940438871473354 319 902 2632,7360,2997 GBE1,UGP2,GYS1 HUMAN_PWY3DJ-11281 sphingomyelin metabolism/ceramide salvage 0.47626496947412 -0.741780921068545 7 3 0.00940438871473354 319 902 166929,259230,6610 SGMS2,SGMS1,SMPD2 HUMAN_PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 0.496373694947422 -0.700426218700792 10 4 0.0125391849529781 319 902 51727,4830,4831,1841 CMPK1,NME1,NME2,DTYMK HUMAN_PWY66-341 cholesterol biosynthesis I 0.511153040830999 -0.671086240797495 13 5 0.0156739811912226 319 902 6309,3930,2222,6307,50814 SC5D,LBR,FDFT1,MSMO1,NSDHL HUMAN_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 0.511153040830999 -0.671086240797495 13 5 0.0156739811912226 319 902 4952,3613,51763,3636,54928 OCRL,IMPA2,INPP5K,INPPL1,BPNT2 HUMAN_PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 0.511153040830999 -0.671086240797495 13 5 0.0156739811912226 319 902 50814,6309,6307,2222,3930 NSDHL,SC5D,MSMO1,FDFT1,LBR HUMAN_PWY66-4 cholesterol biosynthesis III (via desmosterol) 0.511153040830999 -0.671086240797495 13 5 0.0156739811912226 319 902 6309,6307,2222,3930,50814 SC5D,MSMO1,FDFT1,LBR,NSDHL META_PWY-6861 the visual cycle I (vertebrates) 0.511153040830999 -0.671086240797495 13 5 0.0156739811912226 319 902 9227,5948,51109,157506,9249 LRAT,RBP2,RDH11,RDH10,DHRS3 HUMAN_PWY-5667 CDP-diacylglycerol biosynthesis 0.533045704480818 -0.629148108997602 19 7 0.0219435736677116 319 902 10554,57678,51099,10162,55326,256356,2712 AGPAT1,GPAM,ABHD5,LPCAT3,AGPAT5,GK5,GK2 HUMAN_PWY-6564 heparan sulfate biosynthesis 0.549656882348513 -0.598461045706604 25 9 0.0282131661442006 319 902 9957,2131,222537,9955,3340,26035,9348,11285,2135 HS3ST1,EXT1,HS3ST5,HS3ST3A1,NDST1,GLCE,NDST3,B4GALT7,EXTL2 HUMAN_PWY66-5 superpathway of cholesterol biosynthesis 0.549656882348513 -0.598461045706604 25 9 0.0282131661442006 319 902 6307,2222,6309,4597,50814,3930,38,9453,3157 MSMO1,FDFT1,SC5D,MVD,NSDHL,LBR,ACAT1,GGPS1,HMGCS1 META_PWY-6352 3-phosphoinositide biosynthesis 0.549656882348513 -0.598461045706604 25 9 0.0282131661442006 319 902 5294,8394,8503,5290,5296,5295,9896,22908,10423 PIK3CG,PIP5K1A,PIK3R3,PIK3CA,PIK3R2,PIK3R1,FIG4,SACM1L,CDIPT HUMAN_PWY4FS-6 phosphatidylethanolamine biosynthesis II 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 55224,1375 ETNK2,CPT1B META_PWY66-378 androgen biosynthesis 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 3293,1586 HSD17B3,CYP17A1 META_PWY-6342 noradrenaline and adrenaline degradation 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 125,1312 ADH1B,COMT META_CITRULBIO-PWY L-citrulline biosynthesis 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 384,4942 ARG2,OAT META_PWY-7433 mucin core 1 and core 2 O-glycosylation 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 6482,2589 ST3GAL1,GALNT1 META_PWY-4061 glutathione-mediated detoxification I 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 2938,2939 GSTA1,GSTA2 META_PWY-7199 pyrimidine deoxyribonucleosides salvage 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 7298,1633 TYMS,DCK HUMAN_PWY66-378 androgen biosynthesis 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 1586,3293 CYP17A1,HSD17B3 META_PWY-6402 superpathway of melatonin degradation 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 5447,1545 POR,CYP1B1 HUMAN_PWY-7199 pyrimidine deoxyribonucleosides salvage 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 7298,1633 TYMS,DCK META_PWY-5667 CDP-diacylglycerol biosynthesis I 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 55326,10554 AGPAT5,AGPAT1 META_PWY-6398 melatonin degradation I 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 5447,1545 POR,CYP1B1 HUMAN_PLPSAL-PWY pyridoxal 5'-phosphate salvage 0.579035630388406 -0.546391265498704 5 2 0.00626959247648903 319 902 55163,151230 PNPO,KLHL23 HUMAN_SALVADEHYPOX-PWY adenosine nucleotides degradation 0.581518636298588 -0.542112258872154 8 3 0.00940438871473354 319 902 22978,4860,51251 NT5C2,PNP,NT5C3A HUMAN_PWY-6872 retinoate biosynthesis I 0.581518636298588 -0.542112258872154 8 3 0.00940438871473354 319 902 220,195814,83758 ALDH1A3,SDR16C5,RBP5 META_PWY-7426 mannosyl-glycoprotein N-acetylglucosaminyltransferases 0.581518636298588 -0.542112258872154 8 3 0.00940438871473354 319 902 11282,4245,11320 MGAT4B,MGAT1,MGAT4A HUMAN_PWY-6118 glycerol-3-phosphate shuttle 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2820 GPD2 META_PWY-5505 L-glutamate and L-glutamine biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2752 GLUL META_PWY-5670 epoxysqualene biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2222 FDFT1 META_PWY-6181 histamine degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 3176 HNMT HUMAN_PWY-2301 myo-inositol de novo biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 3613 IMPA2 META_PWY-5874 heme degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 644 BLVRA META_PWY-5177 glutaryl-CoA degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 38 ACAT1 HUMAN_FASYN-ELONG-PWY fatty acid elongation -- saturated 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 4706 NDUFAB1 HUMAN_PWY66-14 MAP kinase cascade 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 5604 MAP2K1 HUMAN_GLYSYN-PWY glycine/serine biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 6470 SHMT1 HUMAN_PWY-5686 UMP biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 7372 UMPS HUMAN_PWY-1801 formaldehyde oxidation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2098 ESD META_PWY-6138 CMP-N-acetylneuraminate biosynthesis I (eukaryotes) 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 140838 NANP HUMAN_PWY-6241 thyroid hormone biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 1509 CTSD HUMAN_PWY-5137 fatty acid beta-oxidation (unsaturated, odd number) 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 1962 EHHADH HUMAN_PWY-5340 sulfate activation for sulfonation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 9060 PAPSS2 META_SER-GLYSYN-PWY superpathway of L-serine and glycine biosynthesis I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 6470 SHMT1 HUMAN_PWY66-388 fatty acid alpha-oxidation III 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 79152 FA2H META_PWY-6118 glycerol-3-phosphate shuttle 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2820 GPD2 HUMAN_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 5471 PPAT META_PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 5471 PPAT META_PWY-5453 methylglyoxal degradation III 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 231 AKR1B1 META_PROSYN-PWY L-proline biosynthesis I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 5831 PYCR1 META_PWY-7343 UDP-glucose biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 7360 UGP2 META_PWY-4041 gamma-glutamyl cycle 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2729 GCLC HUMAN_PWY-4041 gamma-glutamyl cycle 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 55748 CNDP2 HUMAN_PWY0-1275 lipoate biosynthesis and incorporation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 11019 LIAS META_UDPNACETYLGALSYN-PWY UDP-N-acetyl-D-glucosamine biosynthesis II 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2673 GFPT1 META_PWY6666-2 dopamine degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 1312 COMT HUMAN_CHOLINE-BETAINE-ANA-PWY choline degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 55349 CHDH HUMAN_PWY-6620 guanine and guanosine salvage 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 4860 PNP META_SERDEG-PWY L-serine degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 10993 SDS HUMAN_PWY-6129 dolichol and dolichyl phosphate biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 79644 SRD5A3 HUMAN_PWY0-1313 acetate conversion to acetyl-CoA 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 55902 ACSS2 META_PWY-6117 spermine and spermidine degradation I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 6303 SAT1 HUMAN_PWY-6138 CMP-N-acetylneuraminate biosynthesis I (eukaryotes) 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 55907 CMAS META_PWY-7179-1 purine deoxyribonucleosides degradation II 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 4860 PNP META_PWY-5340 sulfate activation for sulfonation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 9060 PAPSS2 HUMAN_PWY-5670 epoxysqualene biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2222 FDFT1 META_PLPSAL-PWY pyridoxal 5'-phosphate salvage I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 55163 PNPO META_PWY-6145 superpathway of CMP-sialic acids biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 140838 NANP HUMAN_PWY-7179-1 purine deoxyribonucleosides degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 4860 PNP HUMAN_PWY-6181 histamine degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 3176 HNMT HUMAN_PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 7358 UGDH META_CHOLINE-BETAINE-ANA-PWY choline degradation I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 55349 CHDH HUMAN_PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 127253 TYW3 HUMAN_CYSTEINE-DEG-PWY L-cysteine degradation I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 1036 CDO1 HUMAN_PWY-5525 D-glucuronate degradation 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 51084 CRYL1 META_PWY-6620 guanine and guanosine salvage 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 4860 PNP HUMAN_PWY-5386 methylglyoxal degradation I 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 2739 GLO1 META_PWY-5806 all-trans-decaprenyl diphosphate biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 57107 PDSS2 HUMAN_PROSYN-PWY proline biosynthesis 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 5831 PYCR1 HUMAN_PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 0.582496413192588 -0.54043225117053 2 1 0.00313479623824451 319 902 8790 FPGT HUMAN_PWY-7221 guanosine ribonucleotides de novo biosynthesis 0.585383138936472 -0.535488707775863 11 4 0.0125391849529781 319 902 4831,4830,8833,2987 NME2,NME1,GMPS,GUK1 META_PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 0.585383138936472 -0.535488707775863 11 4 0.0125391849529781 319 902 54928,4952,3613,51763 BPNT2,OCRL,IMPA2,INPP5K HUMAN_PWY-7228 guanosine nucleotides de novo biosynthesis 0.589639058563729 -0.528244694433244 14 5 0.0156739811912226 319 902 4830,4831,6240,2987,8833 NME1,NME2,RRM1,GUK1,GMPS META_PWY-6564 heparan sulfate biosynthesis 0.602483885144297 -0.506694360623495 23 8 0.0250783699059561 319 902 11285,2135,9955,26035,3340,9348,9957,2131 B4GALT7,EXTL2,HS3ST3A1,GLCE,NDST1,NDST3,HS3ST1,EXT1 HUMAN_PWY-6352 3-phosphoinositide biosynthesis 0.659736693088297 -0.415914473429553 27 9 0.0282131661442006 319 902 8394,8503,5290,5296,5294,22908,10423,5295,9896 PIP5K1A,PIK3R3,PIK3CA,PIK3R2,PIK3CG,SACM1L,CDIPT,PIK3R1,FIG4 META_PWY-6571 dermatan sulfate biosynthesis 0.660665369206292 -0.414507816627593 15 5 0.0156739811912226 319 902 55790,79586,55454,11285,10090 CSGALNACT1,CHPF,CSGALNACT2,B4GALT7,UST HUMAN_PWY66-407 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle 0.664282117877589 -0.409048343418419 36 12 0.0376175548589342 319 902 50,5162,6390,3419,8801,5160,4190,5230,1737,2026,6391,1743 ACO2,PDHB,SDHB,IDH3A,SUCLG2,PDHA1,MDH1,PGK1,DLAT,ENO2,SDHC,DLST META_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 0.664502644706049 -0.408716420842703 12 4 0.0125391849529781 319 902 9453,38,3157,4597 GGPS1,ACAT1,HMGCS1,MVD HUMAN_PWY-6061 bile acid biosynthesis, neutral pathway 0.664502644706049 -0.408716420842703 12 4 0.0125391849529781 319 902 1581,1593,5447,10449 CYP7A1,CYP27A1,POR,ACAA2 HUMAN_PWY-6571 dermatan sulfate biosynthesis 0.664502644706049 -0.408716420842703 12 4 0.0125391849529781 319 902 55454,11285,10090,55790 CSGALNACT2,B4GALT7,UST,CSGALNACT1 HUMAN_PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 0.664502644706049 -0.408716420842703 12 4 0.0125391849529781 319 902 38,9453,3157,4597 ACAT1,GGPS1,HMGCS1,MVD HUMAN_PWY-6342 noradrenaline and adrenaline degradation 0.67225184946054 -0.397122232687018 9 3 0.00940438871473354 319 902 125,220074,1312 ADH1B,LRTOMT,COMT HUMAN_MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis 0.67225184946054 -0.397122232687018 9 3 0.00940438871473354 319 902 8818,29880,1798 DPM2,ALG5,DPAGT1 META_PWY-6367 D-myo-inositol-5-phosphate metabolism 0.67225184946054 -0.397122232687018 9 3 0.00940438871473354 319 902 90809,5330,55529 PIP4P1,PLCB2,PIP4P2 HUMAN_PWY-7205 CMP phosphorylation 0.67225184946054 -0.397122232687018 9 3 0.00940438871473354 319 902 51727,4830,4831 CMPK1,NME1,NME2 HUMAN_PWY3DJ-12 ceramide de novo biosynthesis 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 2531,171546 KDSR,SPTSSA META_PWY66-428 L-threonine degradation V 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 1629,10993 DBT,SDS HUMAN_PWY-7455 allopregnanolone biosynthesis 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 1645,1646 AKR1C1,AKR1C2 META_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 4860,22978 PNP,NT5C2 META_PWY-7455 allopregnanolone biosynthesis 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 1646,1645 AKR1C2,AKR1C1 HUMAN_PWY-5695 urate biosynthesis/inosine 5'-phosphate degradation 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 4860,22978 PNP,NT5C2 META_PWY66-367 ketogenesis 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 3157,38 HMGCS1,ACAT1 HUMAN_PWY3O-450 phosphatidylcholine biosynthesis 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 1375,9468 CPT1B,PCYT1B HUMAN_PWY66-428 threonine degradation 0.688527321449041 -0.373200279031347 6 2 0.00626959247648903 319 902 1629,10993 DBT,SDS HUMAN_PWY-7433 mucin core 1 and core 2 O-glycosylation 0.71022212385623 -0.342177507372557 25 8 0.0250783699059561 319 902 6483,2590,6482,8693,79695,9245,6484,2589 ST3GAL2,GALNT2,ST3GAL1,GALNT4,GALNT12,GCNT3,ST3GAL4,GALNT1 META_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism 0.717051082706064 -0.332608195863054 19 6 0.0188087774294671 319 902 54928,3613,4952,5728,51763,3636 BPNT2,IMPA2,OCRL,PTEN,INPP5K,INPPL1 META_ASPARAGINE-DEG1-PWY-1 L-asparagine degradation III (mammalian) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 175 AGA META_PWY-6000 gamma-linolenate biosynthesis II (animals) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_PWY0-1264 biotin-carboxyl carrier protein assembly 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 31 ACACA HUMAN_PWY-5453 methylglyoxal degradation III 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 231 AKR1B1 META_GLYCLEAV-PWY glycine cleavage 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 275 AMT META_PWY66-387 fatty acid alpha-oxidation II 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 5264 PHYH HUMAN_GLUDEG-I-PWY GABA shunt 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 2752 GLUL HUMAN_PWY66-385 dTMP de novo biosynthesis (mitochondrial) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 7298 TYMS META_PWY-6609 adenine and adenosine salvage III 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 4860 PNP META_PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_PWY-7606 docosahexaenoate biosynthesis III (mammals) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 1743 DLST META_PWY66-301 catecholamine biosynthesis 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 1621 DBH META_PWY0-1296 purine ribonucleosides degradation 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 4860 PNP HUMAN_GLYCLEAV-PWY glycine cleavage 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 275 AMT META_PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_PWY66-387 fatty acid alpha-oxidation 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 5264 PHYH META_OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 2539 G6PD META_ARGININE-SYN4-PWY L-ornithine biosynthesis II 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 4942 OAT HUMAN_OXIDATIVEPENT-PWY-1 pentose phosphate pathway (oxidative branch) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 2539 G6PD META_PWY66-422 D-galactose degradation V (Leloir pathway) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 2582 GALE META_GLYCINE-SYN2-PWY glycine biosynthesis II 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 275 AMT HUMAN_PWY-6609 adenine and adenosine salvage III 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 4860 PNP META_PWY66-161 oxidative ethanol degradation III 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 55902 ACSS2 HUMAN_PWY6666-2 dopamine degradation 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 1312 COMT META_PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 1743 DLST HUMAN_PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 4860 PNP META_PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 9415 FADS2 META_PWY66-221 nicotine degradation V 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 316 AOX1 META_MALATE-ASPARTATE-SHUTTLE-PWY L-aspartate degradation II 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 4190 MDH1 HUMAN_PWY-7185 UTP and CTP dephosphorylation I 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 84284 NTPCR META_PWY66-162 ethanol degradation IV 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 55902 ACSS2 META_PWY-7511 protein ubiquitylation 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 55284 UBE2W HUMAN_PWY-7283 wybutosine biosynthesis 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 127253 TYW3 META_PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_ARGININE-SYN4-PWY ornithine de novo biosynthesis 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 4942 OAT HUMAN_PWY-6307 tryptophan degradation via tryptamine 0.730478240075437 -0.314055835948342 3 1 0.00313479623824451 319 902 10327 AKR1A1 HUMAN_PWY0-162 superpathway of pyrimidine ribonucleotides de novo biosynthesis 0.732658024208141 -0.311076228650509 13 4 0.0125391849529781 319 902 7372,51727,4830,4831 UMPS,CMPK1,NME1,NME2 HUMAN_PWY-5328 superpathway of methionine degradation 0.732658024208141 -0.311076228650509 13 4 0.0125391849529781 319 902 27430,1629,4144,1036 MAT2B,DBT,MAT2A,CDO1 HUMAN_PWY-6353 purine nucleotides degradation 0.747628201396676 -0.290849481537735 10 3 0.00940438871473354 319 902 22978,4860,51251 NT5C2,PNP,NT5C3A HUMAN_PWY-922 mevalonate pathway 0.747628201396676 -0.290849481537735 10 3 0.00940438871473354 319 902 4597,38,3157 MVD,ACAT1,HMGCS1 HUMAN_PWY-7227 adenosine deoxyribonucleotides de novo biosynthesis 0.747628201396676 -0.290849481537735 10 3 0.00940438871473354 319 902 6240,4831,4830 RRM1,NME2,NME1 HUMAN_PWY-7226 guanosine deoxyribonucleotides de novo biosynthesis 0.747628201396676 -0.290849481537735 10 3 0.00940438871473354 319 902 6240,4831,4830 RRM1,NME2,NME1 HUMAN_PWY66-201 nicotine degradation IV 0.747628201396676 -0.290849481537735 10 3 0.00940438871473354 319 902 2328,316,11185 FMO3,AOX1,INMT META_PWY-922 mevalonate pathway I 0.747628201396676 -0.290849481537735 10 3 0.00940438871473354 319 902 4597,3157,38 MVD,HMGCS1,ACAT1 HUMAN_PWY-7511 protein ubiquitylation 0.752550703269984 -0.284286904868244 29 9 0.0282131661442006 319 902 27338,7325,7336,7323,7327,9039,10477,7321,55284 UBE2S,UBE2E2,UBE2V2,UBE2D3,UBE2G2,UBA3,UBE2E3,UBE2D1,UBE2W HUMAN_PWY-6358 superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism 0.767956955019495 -0.264021595556921 20 6 0.0188087774294671 319 902 5728,3613,4952,3636,51763,54928 PTEN,IMPA2,OCRL,INPPL1,INPP5K,BPNT2 META_PWY-6872 retinoate biosynthesis I 0.773432262240915 -0.256917185860108 7 2 0.00626959247648903 319 902 220,195814 ALDH1A3,SDR16C5 HUMAN_PWY66-414 superpathway of choline degradation to L-serine 0.773432262240915 -0.256917185860108 7 2 0.00626959247648903 319 902 6470,55349 SHMT1,CHDH META_FAO-PWY fatty acid beta-oxidation I 0.78986561046701 -0.235892461324883 14 4 0.0125391849529781 319 902 3033,1962,10449,3028 HADH,EHHADH,ACAA2,HSD17B10 HUMAN_PWY-7176 UTP and CTP de novo biosynthesis 0.808470099819655 -0.212611582937452 11 3 0.00940438871473354 319 902 51727,4830,4831 CMPK1,NME1,NME2 HUMAN_LIPAS-PWY triacylglycerol degradation 0.808470099819655 -0.212611582937452 11 3 0.00940438871473354 319 902 26090,8228,57406 ABHD12,PNPLA4,ABHD6 META_PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_PWY-6875 retinoate biosynthesis II 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 83758 RBP5 META_PWY-6568 dermatan sulfate biosynthesis (late stages) 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 10090 UST HUMAN_PWY-5123 trans, trans-farnesyl diphosphate biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 9453 GGPS1 HUMAN_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation) 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 1734 DIO2 META_PWY-5872 ubiquinol-10 biosynthesis (eukaryotic) 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 57107 PDSS2 HUMAN_PWY-6823 molybdenum cofactor biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 10243 GPHN META_PWY-6313 serotonin degradation 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 125 ADH1B HUMAN_PWY-5872 ubiquinol-10 biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 57107 PDSS2 HUMAN_PWY66-162 ethanol degradation IV 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 55902 ACSS2 HUMAN_SER-GLYSYN-PWY serine and glycine biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 6470 SHMT1 HUMAN_PWY-5177 glutaryl-CoA degradation 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 38 ACAT1 HUMAN_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 1629 DBT HUMAN_PWY-6568 dermatan sulfate biosynthesis (late stages) 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 10090 UST HUMAN_MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 4190 MDH1 META_PWY-6823 molybdenum cofactor biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 10243 GPHN META_PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 1629 DBT META_PWY66-423 fructose 2,6-bisphosphate biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 5208 PFKFB2 HUMAN_PWY66-423 fructose 2,6-bisphosphate synthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 5208 PFKFB2 HUMAN_PWY-2161 folate polyglutamylation 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 6470 SHMT1 META_PWY-5123 trans, trans-farnesyl diphosphate biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 9453 GGPS1 META_PWY-6158 creatine-phosphate biosynthesis 0.826114993601872 -0.191021297715326 4 1 0.00313479623824451 319 902 1152 CKB HUMAN_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis 0.836847516381647 -0.178113403844726 15 4 0.0125391849529781 319 902 51763,3636,4952,5728 INPP5K,INPPL1,OCRL,PTEN META_PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis 0.836847516381647 -0.178113403844726 15 4 0.0125391849529781 319 902 3636,51763,5728,4952 INPPL1,INPP5K,PTEN,OCRL META_LEU-DEG2-PWY L-leucine degradation I 0.837403470889889 -0.177449280564642 8 2 0.00626959247648903 319 902 1629,549 DBT,AUH HUMAN_PWY-0 putrescine degradation III 0.837403470889889 -0.177449280564642 8 2 0.00626959247648903 319 902 6303,112483 SAT1,SAT2 HUMAN_PWY-2201 folate transformations I 0.837403470889889 -0.177449280564642 8 2 0.00626959247648903 319 902 6470,10840 SHMT1,ALDH1L1 HUMAN_PWY-5451 acetone degradation I (to methylglyoxal) 0.837403470889889 -0.177449280564642 8 2 0.00626959247648903 319 902 125,231 ADH1B,AKR1B1 META_TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation III (eukaryotic) 0.837403470889889 -0.177449280564642 8 2 0.00626959247648903 319 902 3620,38 IDO1,ACAT1 META_PWY-6353 purine nucleotides degradation II (aerobic) 0.884589648443195 -0.122631415579758 9 2 0.00626959247648903 319 902 4860,22978 PNP,NT5C2 META_PWY-4921 protein citrullination 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 11240 PADI2 HUMAN_PWY-5189 tetrapyrrole biosynthesis 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 3145 HMBS META_PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 3620 IDO1 META_PWY-3661-1 glycine betaine degradation II (mammalian) 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 6470 SHMT1 HUMAN_PWY66-161 oxidative ethanol degradation III 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 55902 ACSS2 META_PWY-5189 tetrapyrrole biosynthesis II (from glycine) 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 3145 HMBS HUMAN_PWY66-422 D-galactose degradation V (Leloir pathway) 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 2582 GALE HUMAN_TYRFUMCAT-PWY tyrosine degradation 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 2184 FAH HUMAN_PWY66-367 ketogenesis 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 38 ACAT1 HUMAN_PWY-3661-1 glycine betaine degradation 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 6470 SHMT1 META_TYRFUMCAT-PWY L-tyrosine degradation I 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 2184 FAH META_SALVADEHYPOX-PWY adenosine nucleotides degradation II 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 4860 PNP META_PWY66-375 leukotriene biosynthesis 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 1800 DPEP1 META_PWY-4984 urea cycle 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 384 ARG2 META_PWY-6261 thyroid hormone metabolism II (via conjugation and/or degradation) 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 1734 DIO2 META_VALDEG-PWY L-valine degradation I 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 1629 DBT HUMAN_PWY66-375 leukotriene biosynthesis 0.887884834410416 -0.11891323537983 5 1 0.00313479623824451 319 902 1800 DPEP1 META_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 0.893599619724875 -0.112497456781316 13 3 0.00940438871473354 319 902 5330,8394,10423 PLCB2,PIP5K1A,CDIPT HUMAN_PWY66-391 fatty acid beta-oxidation (peroxisome) 0.893599619724875 -0.112497456781316 13 3 0.00940438871473354 319 902 1962,51,3033 EHHADH,ACOX1,HADH HUMAN_PWY-6367 D-myo-inositol-5-phosphate metabolism 0.904758520403036 -0.100087199171149 17 4 0.0125391849529781 319 902 90809,5330,55529,79837 PIP4P1,PLCB2,PIP4P2,PIP4K2C HUMAN_PWY-6398 melatonin degradation I 0.918830010207119 -0.08465414630713 10 2 0.00626959247648903 319 902 5447,1545 POR,CYP1B1 HUMAN_FAO-PWY fatty acid beta-oxidation 0.921890713159965 -0.0813285948155224 14 3 0.00940438871473354 319 902 3033,3028,10449 HADH,HSD17B10,ACAA2 HUMAN_TRIGLSYN-PWY triacylglycerol biosynthesis 0.925776001272751 -0.0771229728717936 25 6 0.0188087774294671 319 902 10554,57678,55326,10162,196051,51099 AGPAT1,GPAM,AGPAT5,LPCAT3,PLPP4,ABHD5 META_PWY-5130 2-oxobutanoate degradation I 0.927756337005728 -0.0749861485546765 6 1 0.00313479623824451 319 902 1629 DBT META_PWY-5972 stearate biosynthesis I (animals and fungi) 0.927756337005728 -0.0749861485546765 6 1 0.00313479623824451 319 902 79071 ELOVL6 HUMAN_PWY-5996 oleate biosynthesis 0.927756337005728 -0.0749861485546765 6 1 0.00313479623824451 319 902 79966 SCD5 HUMAN_PWY-5130 2-oxobutanoate degradation 0.927756337005728 -0.0749861485546765 6 1 0.00313479623824451 319 902 1629 DBT HUMAN_PWY-6313 serotonin degradation 0.927756337005728 -0.0749861485546765 6 1 0.00313479623824451 319 902 125 ADH1B META_PWY-6557 glycoaminoglycan-protein linkage region biosynthesis 0.927756337005728 -0.0749861485546765 6 1 0.00313479623824451 319 902 11285 B4GALT7 HUMAN_PWY-6557 glycoaminoglycan-protein linkage region biosynthesis 0.927756337005728 -0.0749861485546765 6 1 0.00313479623824451 319 902 11285 B4GALT7 HUMAN_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 0.943151512356443 -0.0585283386753416 15 3 0.00940438871473354 319 902 3636,51763,4952 INPPL1,INPP5K,OCRL META_PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 0.943151512356443 -0.0585283386753416 15 3 0.00940438871473354 319 902 51763,3636,4952 INPP5K,INPPL1,OCRL HUMAN_PWY-6371 superpathway of inositol phosphate compounds 0.943186795206688 -0.0584909298498862 66 18 0.0564263322884013 319 902 8394,8503,9807,79837,5296,90809,3636,9896,51763,5330,5290,5728,4952,5294,55529,22908,10423,5295 PIP5K1A,PIK3R3,IP6K1,PIP4K2C,PIK3R2,PIP4P1,INPPL1,FIG4,INPP5K,PLCB2,PIK3CA,PTEN,OCRL,PIK3CG,PIP4P2,SACM1L,CDIPT,PIK3R1 HUMAN_PWY-5972 stearate biosynthesis 0.943354434738013 -0.0583132082829194 11 2 0.00626959247648903 319 902 79071,64834 ELOVL6,ELOVL1 META_PWY-5004 superpathway of L-citrulline metabolism 0.943354434738013 -0.0583132082829194 11 2 0.00626959247648903 319 902 384,4942 ARG2,OAT HUMAN_PWY-6402 superpathway of melatonin degradation 0.943354434738013 -0.0583132082829194 11 2 0.00626959247648903 319 902 1545,5447 CYP1B1,POR HUMAN_PWY66-221 nicotine degradation III 0.953477016136687 -0.0476399589656038 7 1 0.00313479623824451 319 902 316 AOX1 META_PWY-6369 inositol pyrophosphates biosynthesis 0.953477016136687 -0.0476399589656038 7 1 0.00313479623824451 319 902 9807 IP6K1 HUMAN_PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 0.953477016136687 -0.0476399589656038 7 1 0.00313479623824451 319 902 3620 IDO1 HUMAN_PWY-5994 palmitate biosynthesis 0.953477016136687 -0.0476399589656038 7 1 0.00313479623824451 319 902 4706 NDUFAB1 HUMAN_PWY-6369 inositol pyrophosphates biosynthesis 0.953477016136687 -0.0476399589656038 7 1 0.00313479623824451 319 902 9807 IP6K1 HUMAN_LEU-DEG2-PWY leucine degradation 0.960733471383055 -0.0400582535539669 12 2 0.00626959247648903 319 902 1629,549 DBT,AUH HUMAN_VALDEG-PWY valine degradation 0.960733471383055 -0.0400582535539669 12 2 0.00626959247648903 319 902 1629,3030 DBT,HADHA META_PWY66-391 fatty acid beta-oxidation VI (peroxisome) 0.960733471383055 -0.0400582535539669 12 2 0.00626959247648903 319 902 51,1962 ACOX1,EHHADH HUMAN_PWY66-401 superpathway of tryptophan utilization 0.969260282660467 -0.0312220936037331 32 7 0.0219435736677116 319 902 1545,5447,121278,15,10327,3620,125 CYP1B1,POR,TPH2,AANAT,AKR1A1,IDO1,ADH1B HUMAN_PWY-5920 heme biosynthesis 0.970058951174438 -0.0303984349247612 8 1 0.00313479623824451 319 902 3145 HMBS HUMAN_TRYPTOPHAN-DEGRADATION-1 tryptophan degradation 0.970058951174438 -0.0303984349247612 8 1 0.00313479623824451 319 902 3620 IDO1 META_PWY-5920 superpathway of heme biosynthesis from glycine 0.970058951174438 -0.0303984349247612 8 1 0.00313479623824451 319 902 3145 HMBS META_PWY-5328 superpathway of L-methionine salvage and degradation 0.972939626232495 -0.0274332478142732 13 2 0.00626959247648903 319 902 1036,1629 CDO1,DBT HUMAN_PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 0.98074261401867 -0.0194452248729924 9 1 0.00313479623824451 319 902 56848 SPHK2 META_PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 0.98074261401867 -0.0194452248729924 9 1 0.00313479623824451 319 902 3620 IDO1 META_NADSYN-PWY NAD biosynthesis II (from tryptophan) 0.98074261401867 -0.0194452248729924 9 1 0.00313479623824451 319 902 3620 IDO1 HUMAN_PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 0.984441965440776 -0.0156803308976846 23 4 0.0125391849529781 319 902 8394,5330,79837,10423 PIP5K1A,PLCB2,PIP4K2C,CDIPT META_ANAGLYCOLYSIS-PWY glycolysis III (from glucose) 0.987339511653702 -0.0127413152589931 15 2 0.00626959247648903 319 902 2026,5230 ENO2,PGK1 META_ANAEROFRUCAT-PWY homolactic fermentation 0.987339511653702 -0.0127413152589931 15 2 0.00626959247648903 319 902 2026,5230 ENO2,PGK1 HUMAN_PWY66-400 glycolysis 0.987339511653702 -0.0127413152589931 15 2 0.00626959247648903 319 902 5230,2026 PGK1,ENO2 HUMAN_PWY-7049 icosapentaenoate biosynthesis II (metazoa) 0.987621792222674 -0.0124554559154808 10 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_LIPASYN-PWY phospholipases 0.991707601475825 -0.00832697172331157 29 5 0.0156739811912226 319 902 23646,50640,5330,11145,81579 PLD3,PNPLA8,PLCB2,PLAAT3,PLA2G12A HUMAN_PWY-6309 L-kynurenine degradation 0.992048527971867 -0.00798325356729611 11 1 0.00313479623824451 319 902 3620 IDO1 HUMAN_NADSYN-PWY NAD de novo biosynthesis 0.992048527971867 -0.00798325356729611 11 1 0.00313479623824451 319 902 3620 IDO1 HUMAN_PWY-6000 gamma-linolenate biosynthesis 0.994895351301033 -0.00511772192660317 12 1 0.00313479623824451 319 902 9415 FADS2 HUMAN_PWY-7437 protein O-[N-acetyl]-glucosylation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY66-394 aspirin triggered resolvin E biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_GLUTAMINDEG-PWY glutamine degradation/glutamate biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_GLUDEG-I-PWY GABA shunt 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PROUT-PWY L-proline degradation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY-5030 L-histidine degradation III 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_LYSINE-DEG1-PWY L-lysine degradation XI (mammalian) 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_BETA-ALA-DEGRADATION-I-PWY beta-alanine degradation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY0-1295 pyrimidine ribonucleosides degradation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_LYSINE-DEG1-PWY lysine degradation I (saccharopine pathway) 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY66-397 resolvin D biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PROPIONMET-PWY propanoyl CoA degradation I 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PROPIONMET-PWY propionyl-CoA degradation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY66-395 aspirin triggered resolvin D biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_GLYSYN-ALA-PWY glycine biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_ASPARTATESYN-PWY aspartate biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY66-393 aspirin-triggered lipoxin biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY6666-1 anandamide degradation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY-6124 inosine-5'-phosphate biosynthesis II 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY66-366 flavin biosynthesis IV (mammalian) 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY-7437 protein O-[N-acetyl]-glucosylation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY0-662 PRPP biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY0-1182 trehalose degradation 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY66-395 aspirin triggered resolvin D biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY66-394 aspirin triggered resolvin E biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY66-301 catecholamine biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY66-397 resolvin D biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 HUMAN_PWY-6124 inosine-5'-phosphate biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY0-662 PRPP biosynthesis I 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY3O-4106 NAD salvage pathway III 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY-0 putrescine degradation III 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY66-393 aspirin-triggered lipoxin biosynthesis 0.999999999993652 -6.34789443232364e-12 2 0 0 319 902 META_PWY-6100 L-carnitine biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-7177 UTP and CTP dephosphorylation II 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY-6430 thymine degradation 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY0-1295 pyrimidine ribonucleosides degradation 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-3982 uracil degradation I (reductive) 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PHENYLALANINE-DEG1-PWY phenylalanine degradation/tyrosine biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY-6554 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_2PHENDEG-PWY phenylethylamine degradation I 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-5661 GDP-glucose biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY66-392 lipoxin biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_HEME-BIOSYNTHESIS-II heme biosynthesis I (aerobic) 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_ADENOSYLHOMOCYSCAT-PWY methionine salvage 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-6875 retinoate biosynthesis II 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-6405 Rapoport-Luebering glycolytic shunt 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-7185 UTP and CTP dephosphorylation I 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY-6158 creatine-phosphate biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY-6100 L-carnitine biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-5996 oleate biosynthesis II (animals and fungi) 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-6318 L-phenylalanine degradation IV (mammalian, via side chain) 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY-5661-1 GDP-glucose biosynthesis II 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_NAD-BIOSYNTHESIS-III NAD salvage 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY66-392 lipoxin biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 HUMAN_PWY-3982 uracil degradation 0.99999999999896 -1.04027203517987e-12 3 0 0 319 902 META_PWY-6173 histamine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_ARGSPECAT-PWY spermine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5326 sulfite oxidation IV 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY66-366 flavin biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_BGALACT-PWY lactose degradation III 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY66-380 estradiol biosynthesis I (via estrone) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6377 alpha-tocopherol degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6535 4-aminobutanoate degradation I 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-5754 4-hydroxybenzoate biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_GLUTAMATE-SYN2-PWY L-glutamate biosynthesis II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-7506 phosphatidylserine biosynthesis II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_SERSYN-PWY serine biosynthesis (phosphorylated route) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5686 UMP biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5966 fatty acid biosynthesis initiation II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-5963 thio-molybdenum cofactor biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6173 histamine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_P121-PWY adenine and adenosine salvage I 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6481 L-dopachrome biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6938 NADH repair 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5172 acetyl-CoA biosynthesis III (from citrate) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_MANNCAT-PWY D-mannose degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-5172 acetyl-CoA biosynthesis from citrate 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6133 (S)-reticuline biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-7506 phosphatidylserine biosynthesis II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY0-1021 L-alanine biosynthesis III 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6273 phosphatidylethanolamine biosynthesis III 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5329 L-cysteine degradation III 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6132 lanosterol biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_GLUT-REDOX-PWY glutathione redox reactions II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6307 L-tryptophan degradation X (mammalian, via tryptamine) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY66-426 hydrogen sulfide biosynthesis (trans-sulfuration) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-5326 sulfite oxidation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PROUT-PWY proline degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_ARGSPECAT-PWY spermine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_HOMOCYSDEGR-PWY cysteine biosynthesis/homocysteine degradation (trans-sulfuration) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6292 superpathway of L-cysteine biosynthesis (mammalian) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6134 L-tyrosine biosynthesis IV 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6938 NADH repair 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY0-522 lipoate salvage 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6399 melatonin degradation II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6377 alpha-tocopherol degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_MGLDLCTANA-PWY methylglyoxal degradation VI 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5754 4-hydroxybenzoate biosynthesis I (eukaryotes) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_GLUTAMATE-SYN2-PWY glutamate biosynthesis/degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5886 4-hydroxyphenylpyruvate biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_SERDEG-PWY L-serine degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and dephosphorylation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6535 4-aminobutyrate degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6405 Rapoport-Luebering glycolytic shunt 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_ASPARTATESYN-PWY L-aspartate biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY66-421 homocarnosine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY66-420 carnosine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_GLUT-REDOX-PWY glutathione-glutaredoxin redox reactions 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6481 L-dopachrome biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-6898 thiamin salvage III 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-5766 L-glutamate degradation X 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6132 lanosterol biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_MGLDLCTANA-PWY methylglyoxal degradation VI 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY66-420 carnosine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-5148 acyl-CoA hydrolysis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-5329 L-cysteine degradation II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-6133 (S)-reticuline biosynthesis II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-1722 formate assimilation into 5,10-methylenetetrahydrofolate 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-7592 arachidonate biosynthesis III (metazoa) 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY6666-1 anandamide degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 HUMAN_PWY-7306 estradiol biosynthesis II 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY66-241 bupropion degradation 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY66-421 homocarnosine biosynthesis 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY66-388 fatty acid alpha-oxidation III 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_HISHP-PWY L-histidine degradation VI 1.00000000000093 9.31310584206813e-13 1 0 0 319 902 META_PWY-7181 pyrimidine deoxyribonucleosides degradation 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_PWY-7177 UTP and CTP dephosphorylation II 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_HYDROXYPRODEG-PWY 4-hydroxyproline degradation 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 META_PWY-5994 palmitate biosynthesis I (animals and fungi) 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_PWY-6755 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_PWY-4921 protein citrullination 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 META_PWY66-373 sucrose degradation V (sucrose alpha-glucosidase) 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 META_HYDROXYPRODEG-PWY trans-4-hydroxy-L-proline degradation I 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_PWY-4984 urea cycle 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 META_PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 1.00000000000438 4.3781072517346e-12 4 0 0 319 902 HUMAN_PWY-4983 citrulline-nitric oxide cycle 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 HUMAN_PWY-5030 histidine degradation 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 HUMAN_PWY66-241 bupropion degradation 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 HUMAN_PWY-7180 2'-deoxy-alpha-D-ribose 1-phosphate degradation 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 HUMAN_COA-PWY-1 coenzyme A biosynthesis 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 META_PWY-7209 superpathway of pyrimidine ribonucleosides degradation 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 HUMAN_PWY-7181 pyrimidine deoxyribonucleosides degradation 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 META_PWY-4983 L-citrulline-nitric oxide cycle 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 META_COA-PWY-1 coenzyme A biosynthesis II (mammalian) 1.00000000000845 8.44802439808889e-12 5 0 0 319 902 HUMAN_PWY-5143 fatty acid activation 1.00000000001093 1.09283018832201e-11 6 0 0 319 902 HUMAN_PWY-7209 pyrimidine ribonucleosides degradation 1.00000000001093 1.09283018832201e-11 6 0 0 319 902 HUMAN_PWY66-373 sucrose degradation 1.00000000001093 1.09283018832201e-11 6 0 0 319 902