TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
WP289	Myometrial Relaxation and Contraction Pathways	0.00071573657272278	-7.24219837389268	158	152	0.0322238711045156	4717	5310	2786,85366,784,2776,23764,10267,58,805,409,9628,1386,5582,113,8787,815,27297,488,112,467,468,55970,107,6001,3553,108,2870,4633,94235,3487,114,5580,6667,466,1385,59345,5570,196883,60,5575,3725,7533,5331,10971,10266,10699,6000,5335,5996,2784,1265,5581,6263,3710,11318,5576,9446,2353,70,22809,7529,10268,5566,3488,2810,71,111,4790,3489,2697,2782,5336,2980,2778,2783,2788,133,2114,26575,10287,1388,4846,5997,57007,5144,7534,8601,4635,5020,1394,6262,801,2792,3484,5577,2982,796,5587,1902,6546,5567,54331,1392,59,7532,5142,51764,122042,2787,6013,10636,10681,408,59350,100616483,3569,5998,8490,6261,115,64407,8525,8786,3485,5999,3708,808,2981,11142,5579,5590,816,2551,5573,2791,5578,5583,4842,3709,5588,10488,800,109,3486,817,2869,818,7531,5021,5333,5569,489,2868	GNG4,MYLK2,CACNB3,GNAQ,MAFF,RAMP1,ACTA1,CALM2,ARRB2,RGS6,ATF2,PRKCG,ADCY7,RGS9,CAMK2A,CRCP,ATP2A2,ADCY6,ATF3,ATF4,GNG12,ADCY1,RGS10,IL1B,ADCY2,GRK6,MYL2,GNG8,IGFBP4,ADCY8,PRKCD,SP1,ATF1,CREB1,GNB4,PKIB,ADCY4,ACTB,PRKAR1B,JUN,YWHAH,PLCB3,YWHAQ,RAMP2,CORIN,RGS7,PLCG1,RGS1,GNB3,CNN2,PRKCE,RYR3,ITPR3,GPR182,PRKAR2A,GSTO1,FOS,ACTC1,ATF5,YWHAB,RAMP3,PRKACA,IGFBP5,SFN,ACTG1,ADCY5,NFKB1,IGFBP6,GJA1,GNB1,PLCG2,GUCA2A,GNAS,GNB2,GNG7,ADM,ETS2,RGS17,RGS19,ATF6B,NOS3,RGS2,ACKR3,PDE4D,YWHAZ,RGS20,MYL4,OXT,CRHR1,RYR2,CALM1,GNGT1,IGFBP1,PRKAR2B,GUCY1A1,CALCA,PRKD1,LPAR1,SLC8A1,PRKACB,GNG2,CRH,ACTA2,YWHAG,PDE4B,GNG13,RXFP2,GNG5,RLN1,RGS14,GNB5,ARRB1,RXFP1,MIR4751,IL6,RGS3,RGS5,RYR1,ADCY9,RGS18,DGKZ,RGS11,IGFBP2,RGS4,ITPR1,CALM3,GUCA2B,PKIG,PRKCB,PRKCZ,CAMK2B,GABPA,PRKAR1A,GNG11,PRKCA,PRKCH,NOS1,ITPR2,PRKCQ,CREB3,CALD1,ADCY3,IGFBP3,CAMK2D,GRK5,CAMK2G,YWHAE,OXTR,PLCD1,PKIA,ATP2A3,GRK4
WP236	Adipogenesis	0.00219688145305509	-6.12071644559029	131	126	0.0267118931524274	4717	5310	3952,6517,4692,6667,4000,8648,1385,3572,1050,3399,8609,1874,5933,2624,6695,3091,9663,4209,650,6256,355,652,4208,2662,6773,6778,56729,7124,5467,7480,5740,1052,7040,28999,2626,3479,7471,3630,3977,8651,649,7350,7025,81029,5054,196,1316,2625,688,10499,10658,1675,8788,26580,4207,5346,1271,2487,5008,6777,651,434,23175,5468,7291,2908,1051,9021,6424,3991,6319,55847,9612,1647,80339,1855,4205,9370,5925,3976,1959,2303,57761,2308,83881,6258,5914,10135,1592,1026,6776,3159,6927,8660,10062,4282,8321,2034,1879,6772,6095,5934,4088,9611,123,5618,5105,2971,1869,4023,8204,2688,183,25937,5465,3569,6774,4616,4154,10891,64900,1499,10269,56603,6720,3667	LEP,SLC2A4,NDN,SP1,LMNA,NCOA1,CREB1,IL6ST,CEBPA,ID3,KLF7,E2F4,RBL1,GATA2,SPOCK1,HIF1A,LPIN2,MEF2D,BMP2,RXRA,FAS,BMP4,MEF2C,GDF10,STAT2,STAT6,RETN,TNF,PPARD,WNT10B,PTGIS,CEBPD,TGFB1,KLF15,GATA4,IGF1,WNT1,INS,LIFR,SOCS1,BMP1,UCP1,NR2F1,WNT5B,SERPINE1,AHR,KLF6,GATA3,KLF5,NCOA2,CELF1,CFD,DLK1,BSCL2,BORCS8-MEF2B,PLIN1,CNTFR,FRZB,OSM,STAT5B,BMP3,ASIP,LPIN1,PPARG,TWIST1,NR3C1,CEBPB,SOCS3,SFRP4,LIPE,SCD,CISD1,NCOR2,GADD45A,PNPLA3,DVL1,MEF2A,ADIPOQ,RB1,LIF,EGR2,FOXC2,TRIB3,FOXO1,MIXL1,RXRG,RARA,NAMPT,CYP26A1,CDKN1A,STAT5A,HMGA1,HNF1A,IRS2,NR1H3,MIF,FZD1,EPAS1,EBF1,STAT1,RORA,RBL2,SMAD3,NCOR1,PLIN2,PRLR,PCK1,GTF3A,E2F1,LPL,NRIP1,GH1,AGT,WWTR1,PPARA,IL6,STAT3,GADD45B,MBNL1,PPARGC1A,LPIN3,CTNNB1,ZMPSTE24,CYP26B1,SREBF1,IRS1
WP1403	AMP-activated Protein Kinase (AMPK) Signaling	0.00291558110832057	-5.83768612799409	68	67	0.0142039431842273	4717	5310	3643,2194,10645,3172,200186,6794,5562,2998,723961,3156,133522,1026,57521,9370,32,207,5209,208,53632,51719,5567,6517,3952,79602,7248,5290,890,5294,5289,2475,5564,147,148,7249,29904,5565,5571,51094,4207,31,23236,5295,2997,1994,6720,6199,8900,3991,5291,3953,6198,1978,126129,1374,51422,5296,8503,891,5293,5563,5568,92335,56731,84254,7157,55437,1938	INSR,FASN,CAMKK2,HNF4A,CRTC2,STK11,PRKAA1,GYS2,INS-IGF2,HMGCR,PPARGC1B,CDKN1A,RPTOR,ADIPOQ,ACACB,AKT1,PFKFB3,AKT2,PRKAG3,CAB39,PRKACB,SLC2A4,LEP,ADIPOR2,TSC1,PIK3CA,CCNA2,PIK3CG,PIK3C3,MTOR,PRKAB1,ADRA1B,ADRA1A,TSC2,EEF2K,PRKAB2,PRKAG1,ADIPOR1,BORCS8-MEF2B,ACACA,PLCB1,PIK3R1,GYS1,ELAVL1,SREBF1,RPS6KB2,CCNA1,LIPE,PIK3CB,LEPR,RPS6KB1,EIF4EBP1,CPT1C,CPT1A,PRKAG2,PIK3R2,PIK3R3,CCNB1,PIK3CD,PRKAA2,PRKACG,STRADA,SLC2A4RG,CAMKK1,TP53,STRADB,EEF2
WP2586	Aryl Hydrocarbon Receptor	0.00330942758136904	-5.71098004069063	48	48	0.0101759592961628	4717	5310	1869,5594,135112,4023,8204,5325,9049,196,4763,1544,100302237,4790,5604,1027,11140,4893,1316,2099,84722,5970,5743,948,100302213,1543,4780,405,2033,1956,7422,9612,5894,3320,3265,3845,27306,26291,5925,6346,5979,7124,1026,4609,1545,1728,2729,6714,1017,57491	E2F1,MAPK1,NCOA7,LPL,NRIP1,PLAGL1,AIP,AHR,NF1,CYP1A2,MIR1281,NFKB1,MAP2K1,CDKN1B,CDC37,NRAS,KLF6,ESR1,PSRC1,RELA,PTGS2,CD36,MIR1181,CYP1A1,NFE2L2,ARNT,EP300,EGFR,VEGFA,NCOR2,RAF1,HSP90AA1,HRAS,KRAS,HPGDS,FGF21,RB1,CCL1,RET,TNF,CDKN1A,MYC,CYP1B1,NQO1,GCLC,SRC,CDK2,AHRR
WP2873	Aryl Hydrocarbon Receptor Pathway	0.00330942758136904	-5.71098004069063	48	48	0.0101759592961628	4717	5310	1728,1545,7040,7124,54578,57491,3593,27190,26509,54658,3458,6714,8140,5055,10728,3553,54659,1956,3558,218,2033,3727,405,4780,1543,3484,100302213,4257,8648,3320,581,11140,54600,3725,23491,1027,3280,10486,3726,196,9049,3592,54657,2939,54577,100302237,1544,51426	NQO1,CYP1B1,TGFB1,TNF,UGT1A6,AHRR,IL12B,IL17B,MYOF,UGT1A1,IFNG,SRC,SLC7A5,SERPINB2,PTGES3,IL1B,UGT1A3,EGFR,IL2,ALDH3A1,EP300,JUND,ARNT,NFE2L2,CYP1A1,IGFBP1,MIR1181,MGST1,NCOA1,HSP90AA1,BAX,CDC37,UGT1A9,JUN,CES3,CDKN1B,HES1,CAP2,JUNB,AHR,AIP,IL12A,UGT1A4,GSTA2,UGT1A7,MIR1281,CYP1A2,POLK
WP2261	Signaling Pathways in Glioblastoma	0.00333818329811821	-5.70232854269225	83	81	0.0171719313122748	4717	5310	6416,5728,2064,1027,5291,3667,2885,4893,595,5295,1019,5335,675,472,54206,2263,4194,5590,5579,5594,7157,1869,5287,4763,5583,5588,5607,1030,5578,100302237,5336,5604,5293,5296,5605,1026,1029,1031,10000,867,6714,5170,5582,673,2308,2309,10253,5595,1017,5286,5159,7249,3480,5609,5288,5294,4233,1956,5608,5156,5606,7248,5290,672,2033,5894,4193,2260,1021,2956,5925,898,3845,894,2065,208,5584,5580,207,3265,2549	MAP2K4,PTEN,ERBB2,CDKN1B,PIK3CB,IRS1,GRB2,NRAS,CCND1,PIK3R1,CDK4,PLCG1,BRCA2,ATM,ERRFI1,FGFR2,MDM4,PRKCZ,PRKCB,MAPK1,TP53,E2F1,PIK3C2B,NF1,PRKCH,PRKCQ,MAP2K5,CDKN2B,PRKCA,MIR1281,PLCG2,MAP2K1,PIK3CD,PIK3R2,MAP2K2,CDKN1A,CDKN2A,CDKN2C,AKT3,CBL,SRC,PDPK1,PRKCG,BRAF,FOXO1,FOXO3,SPRY2,MAPK3,CDK2,PIK3C2A,PDGFRB,TSC2,IGF1R,MAP2K7,PIK3C2G,PIK3CG,MET,EGFR,MAP2K6,PDGFRA,MAP2K3,TSC1,PIK3CA,BRCA1,EP300,RAF1,MDM2,FGFR1,CDK6,MSH6,RB1,CCNE1,KRAS,CCND2,ERBB3,AKT2,PRKCI,PRKCD,AKT1,HRAS,GAB1
WP366	TGF-beta Signaling Pathway	0.00550181243380204	-5.20267770760937	133	127	0.0269238923044308	4717	5310	1386,10413,983,6497,5601,860,4208,5605,2335,4609,7040,57154,7015,207,8462,6667,5599,8945,467,1874,9839,2033,5606,5933,4233,5494,1601,163126,8554,1316,6654,857,5163,2113,6498,4739,7046,6935,1875,9972,3371,3725,55802,7329,6416,10987,11184,2885,6464,9146,7057,64750,150094,8021,5604,7157,7041,5371,7071,2353,3726,5576,3688,9564,10131,9372,6714,3673,3690,79753,5747,7027,1026,998,3985,5879,4205,10454,5596,5062,351,5894,9978,2354,4087,387,3727,51377,5608,22938,1387,5295,83737,9133,23327,7049,595,4092,9765,7048,57559,4321,7189,11171,25942,3065,6885,1432,4312,6500,4089,6711,11059,100302237,5296,9063,5934,3691,4088,8454,5594,7341,7050,8312,54778,1278,1030	ATF2,YAP1,CDK1,SKI,MAPK9,RUNX2,MEF2C,MAP2K2,FN1,MYC,TGFB1,SMURF1,TERT,AKT1,KLF11,SP1,MAPK8,BTRC,ATF3,E2F4,ZEB2,EP300,MAP2K3,RBL1,MET,PPM1A,DAB2,EID2,PIAS1,KLF6,SOS1,CAV1,PDK1,ETS1,SKIL,NEDD9,TGFBR1,ZEB1,E2F5,NUP153,TNC,JUN,DCP1A,UBE2I,MAP2K4,COPS5,MAP4K1,GRB2,SHC1,HGS,THBS1,SMURF2,SIK1,NUP214,MAP2K1,TP53,TGFB1I1,PML,KLF10,FOS,JUNB,PRKAR2A,ITGB1,BCAR1,TRAP1,ZFYVE9,SRC,ITGA2,ITGB3,SNIP1,PTK2,TFDP1,CDKN1A,CDC42,LIMK2,RAC1,MEF2A,TAB1,MAPK4,PAK2,APP,RAF1,RBX1,FOSB,SMAD2,RHOA,JUND,UCHL5,MAP2K6,SNW1,CREBBP,PIK3R1,ITCH,CCNB2,NEDD4L,TGFBR3,CCND1,SMAD7,ZFYVE16,TGFBR2,STAMBPL1,MMP12,TRAF6,STRAP,SIN3A,HDAC1,MAP3K7,MAPK14,MMP1,SKP1,SMAD4,SPTBN1,WWP1,MIR1281,PIK3R2,PIAS2,RBL2,ITGB4,SMAD3,CUL1,MAPK1,SUMO1,TGIF1,AXIN1,RNF111,COL1A2,CDKN2B
WP615	Senescence and Autophagy in Cancer	0.00574407865414029	-5.15958575406042	106	102	0.021623913504346	4717	5310	84557,5055,81631,3570,650,673,3456,9547,2919,6348,64422,1029,7040,2335,4193,9474,8678,3572,3265,8878,84335,11345,6041,3621,596,3562,3665,9966,9140,3553,960,5606,1300,55054,83734,1281,100500837,3624,1051,10533,29986,1027,3576,3725,29985,7057,3488,3622,3659,5604,3490,3479,3630,23710,7157,6678,5054,4323,3428,7405,6714,23770,4297,3458,1026,51100,5327,2932,3663,3159,11009,994,648,5111,5894,5925,440738,2934,9821,3480,11337,1277,2475,5289,3552,64223,3569,5728,55626,5328,26156,8408,22863,1432,3486,4089,4088,8804,3916,1869,5594,9776	MAP1LC3A,SERPINB2,MAP1LC3B,IL6R,BMP2,BRAF,IFNB1,CXCL14,CXCL1,CCL3,ATG3,CDKN2A,TGFB1,FN1,MDM2,ATG5,BECN1,IL6ST,HRAS,SQSTM1,AKT1S1,GABARAPL2,RNASEL,ING1,BCL2,IL3,IRF7,TNFSF15,ATG12,IL1B,CD44,MAP2K3,COL10A1,ATG16L1,ATG10,COL3A1,MIR3606,INHBA,CEBPB,ATG7,SLC39A2,CDKN1B,CXCL8,JUN,SLC39A3,THBS1,IGFBP5,ING2,IRF1,MAP2K1,IGFBP7,IGF1,INS,GABARAPL1,TP53,SPARC,SERPINE1,MMP14,IFI16,UVRAG,SRC,FKBP8,KMT2A,IFNG,CDKN1A,SH3GLB1,PLAT,GSK3B,IRF5,HMGA1,IL24,CDC25B,BMI1,PCNA,RAF1,RB1,MAP1LC3C,GSN,RB1CC1,IGF1R,GABARAP,COL1A1,MTOR,PIK3C3,IL1A,MLST8,IL6,PTEN,AMBRA1,PLAU,RSL1D1,ULK1,ATG14,MAPK14,IGFBP3,SMAD4,SMAD3,CREG1,LAMP1,E2F1,MAPK1,ATG13
WP3915	Angiopoietin Like Protein 8 Regulatory Pathway	0.00594721106757077	-5.12483289745134	132	126	0.0267118931524274	4717	5310	6464,6199,1398,6319,11184,6416,6198,1978,5565,5571,9175,25759,6654,5602,4296,79109,253260,3630,1734,23624,10211,5604,5293,5600,8503,6513,5597,4217,1326,5770,868,5871,8986,143686,867,5562,5605,9252,57521,1977,4294,10746,64240,5601,1581,55908,2194,6256,9064,9020,5606,7248,1576,5286,7249,6655,5564,5599,208,207,3265,6517,5598,23433,5291,3667,2319,6885,1432,6720,4216,2997,2931,6300,7068,51422,6196,23265,5295,4293,64223,30849,2889,5607,6195,2203,9448,4023,4215,5594,1555,11183,5105,5296,53919,10062,5563,8660,2932,9322,64241,4214,2309,5595,5170,10487,2538,6009,3643,51085,2308,6721,5294,5603,5289,2475,5608,5290,53358,50488,5288,5609,53632,5894,5596,8491	SHC1,RPS6KB2,CRK,SCD,MAP4K1,MAP2K4,RPS6KB1,EIF4EBP1,PRKAB2,PRKAG1,MAP3K13,SHC2,SOS1,MAPK10,MAP3K11,MAPKAP1,RICTOR,INS,DIO2,CBLC,FLOT1,MAP2K1,PIK3CD,MAPK11,PIK3R3,SLC2A1,MAPK6,MAP3K5,MAP3K8,PTPN1,CBLB,MAP4K2,RPS6KA4,SESN3,CBL,PRKAA1,MAP2K2,RPS6KA5,RPTOR,EIF4E,MAP3K10,MAP3K2,ABCG5,MAPK9,CYP7A1,ANGPTL8,FASN,RXRA,MAP3K6,MAP3K14,MAP2K3,TSC1,CYP3A4,PIK3C2A,TSC2,SOS2,PRKAB1,MAPK8,AKT2,AKT1,HRAS,SLC2A4,MAPK7,RHOQ,PIK3CB,IRS1,FLOT2,MAP3K7,MAPK14,SREBF1,MAP3K4,GYS1,GSK3A,MAPK12,THRB,PRKAG2,RPS6KA2,EXOC7,PIK3R1,MAP3K9,MLST8,PIK3R4,RAPGEF1,MAP2K5,RPS6KA1,FBP1,MAP4K4,LPL,MAP3K3,MAPK1,CYP2B6,MAP4K5,PCK1,PIK3R2,SLCO1C1,NR1H3,PRKAA2,IRS2,GSK3B,TRIP10,ABCG8,MAP3K1,FOXO3,MAPK3,PDPK1,CAP1,G6PC1,RHEB,INSR,MLXIPL,FOXO1,SREBF2,PIK3CG,MAPK13,PIK3C3,MTOR,MAP2K6,PIK3CA,SHC3,MINK1,PIK3C2G,MAP2K7,PRKAG3,RAF1,MAPK4,MAP4K3
WP481	Insulin Signaling	0.0106239127829701	-4.54464789571605	161	152	0.0322238711045156	4717	5310	1958,5290,2475,5608,5289,5294,5603,2887,5288,5609,4641,6616,10580,3480,50488,9265,53358,2549,382,10110,6844,5879,8491,5596,5894,2998,2932,5595,2309,3551,4214,2308,57761,3643,6009,5170,10487,9448,5578,6195,5607,2889,5588,5583,30849,2888,5594,5579,4215,5590,5867,6722,5296,5792,11183,8660,6814,5563,9882,6810,4216,2997,1432,6885,2319,3667,5291,6196,6300,252983,2931,5728,6812,7494,6236,4293,5295,23678,7248,5606,375,9064,9020,3799,6813,6655,7249,5286,3265,207,5580,11127,208,5584,5599,23433,10938,57381,5598,6517,3636,5562,867,8986,868,5871,5770,4217,1326,3631,10746,4294,1977,6446,9252,5605,5167,5601,5781,5880,2353,10603,23624,30846,8651,5506,8503,5600,5604,5293,10211,2992,5597,6513,9021,11184,2885,1398,6464,6199,3991,6198,1978,3725,6416,9175,6654,25759,8773,5211,4296,5602	EGR1,PIK3CA,MTOR,MAP2K6,PIK3C3,PIK3CG,MAPK13,GRB10,PIK3C2G,MAP2K7,MYO1C,SNAP25,SORBS1,IGF1R,MINK1,CYTH3,SHC3,GAB1,ARF6,SGK2,VAMP2,RAC1,MAP4K3,MAPK4,RAF1,GYS2,GSK3B,MAPK3,FOXO3,IKBKB,MAP3K1,FOXO1,TRIB3,INSR,RHEB,PDPK1,CAP1,MAP4K4,PRKCA,RPS6KA1,MAP2K5,RAPGEF1,PRKCQ,PRKCH,PIK3R4,GRB14,MAPK1,PRKCB,MAP3K3,PRKCZ,RAB4A,SRF,PIK3R2,PTPRF,MAP4K5,IRS2,STXBP3,PRKAA2,TBC1D4,STX4,MAP3K4,GYS1,MAPK14,MAP3K7,FLOT2,IRS1,PIK3CB,RPS6KA2,MAPK12,STXBP4,GSK3A,PTEN,STXBP1,XBP1,RRAD,MAP3K9,PIK3R1,SGK3,TSC1,MAP2K3,ARF1,MAP3K6,MAP3K14,KIF5B,STXBP2,SOS2,TSC2,PIK3C2A,HRAS,AKT1,PRKCD,KIF3A,AKT2,PRKCI,MAPK8,RHOQ,EHD1,RHOJ,MAPK7,SLC2A4,INPPL1,PRKAA1,CBL,RPS6KA4,CBLB,MAP4K2,PTPN1,MAP3K5,MAP3K8,INPP4A,MAP3K2,MAP3K10,EIF4E,SGK1,RPS6KA5,MAP2K2,ENPP1,MAPK9,PTPN11,RAC2,FOS,SH2B2,CBLC,EHD2,SOCS1,PPP1R3A,PIK3R3,MAPK11,MAP2K1,PIK3CD,FLOT1,GYG1,MAPK6,SLC2A1,SOCS3,MAP4K1,GRB2,CRK,SHC1,RPS6KB2,LIPE,RPS6KB1,EIF4EBP1,JUN,MAP2K4,MAP3K13,SOS1,SHC2,SNAP23,PFKL,MAP3K11,MAPK10
WP45	G1 to S cell cycle control	0.0140623088157623	-4.26425719443348	68	66	0.0139919440322239	4717	5310	4172,901,5000,1388,983,8318,6117,1017,9134,1026,5427,7027,1028,5558,90993,4609,23649,1029,84699,1031,4193,1647,5111,1021,898,894,4174,5925,4661,1385,1874,23595,896,1870,5933,993,1019,595,6119,472,4171,6118,1875,1871,4175,1027,1032,5557,902,7029,8900,4999,5001,1876,148327,4998,891,1022,23594,7465,4331,1869,7157,10488,1030,4173	MCM3,CCNG2,ORC4,ATF6B,CDK1,CDC45,RPA1,CDK2,CCNE2,CDKN1A,POLE2,TFDP1,CDKN1C,PRIM2,CREB3L1,MYC,POLA2,CDKN2A,CREB3L3,CDKN2C,MDM2,GADD45A,PCNA,CDK6,CCNE1,CCND2,MCM5,RB1,MYT1,CREB1,E2F4,ORC3,CCND3,E2F2,RBL1,CDC25A,CDK4,CCND1,RPA3,ATM,MCM2,RPA2,E2F5,E2F3,MCM6,CDKN1B,CDKN2D,PRIM1,CCNH,TFDP2,CCNA1,ORC2,ORC5,E2F6,CREB3L4,ORC1,CCNB1,CDK7,ORC6,WEE1,MNAT1,E2F1,TP53,CREB3,CDKN2B,MCM4
WP2032	Human Thyroid Stimulating Hormone (TSH) signaling pathway	0.0140623088157623	-4.26425719443348	68	66	0.0139919440322239	4717	5310	896,3480,1958,5290,1081,5606,2475,108,5608,2771,8458,3716,5894,54331,3265,207,1385,5337,30818,406974,898,7849,7252,5925,10672,2778,2773,2776,103910,4609,5909,673,6194,5144,5170,6714,5595,2768,1017,5906,5908,1869,5594,6195,23513,2353,3717,109,6772,5296,7270,5604,2782,5934,1027,6198,3725,7253,5900,1432,6774,1019,5295,23236,2770,100126338	CCND3,IGF1R,EGR1,PIK3CA,CGA,MAP2K3,MTOR,ADCY2,MAP2K6,GNAI2,TTF2,JAK1,RAF1,GNG2,HRAS,AKT1,CREB1,PLD1,KCNIP3,MIR197,CCNE1,PAX8,TSHB,RB1,GNA13,GNAS,GNAI3,GNAQ,MYL12B,MYC,RAP1GAP,BRAF,RPS6,PDE4D,PDPK1,SRC,MAPK3,GNA12,CDK2,RAP1A,RAP1B,E2F1,MAPK1,RPS6KA1,SCRIB,FOS,JAK2,ADCY3,STAT1,PIK3R2,TTF1,MAP2K1,GNB1,RBL2,CDKN1B,RPS6KB1,JUN,TSHR,RALGDS,MAPK14,STAT3,CDK4,PIK3R1,PLCB1,GNAI1,MIR937
WP35	G Protein Signaling Pathways	0.0143663125426643	-4.24286921984682	95	91	0.0192919228323087	4717	5310	9495,6237,2768,5530,5151,113,5144,9472,2769,5582,10270,2790,805,2788,2783,2776,2778,2786,2773,3845,10566,5584,5142,10672,196883,3265,3760,114,5580,406974,2781,6548,94235,27115,2771,5567,5587,108,23683,5153,107,5577,55970,387,5137,112,801,2792,11214,5581,9465,8622,2767,2793,2784,115,2770,9138,9590,2774,5533,4893,10681,5331,2787,5143,5575,51764,2782,5150,729966,111,9630,5141,5566,8165,5568,10142,109,5588,5576,5583,5578,11216,2791,5573,5579,5590,3708,11215,5136	AKAP5,RRAS,GNA12,PPP3CA,PDE8A,ADCY7,PDE4D,AKAP6,GNA15,PRKCG,AKAP8,GNG10,CALM2,GNG7,GNB2,GNAQ,GNAS,GNG4,GNAI3,KRAS,AKAP3,PRKCI,PDE4B,GNA13,ADCY4,HRAS,KCNJ3,ADCY8,PRKCD,MIR197,GNAZ,SLC9A1,GNG8,PDE7B,GNAI2,PRKACB,PRKD1,ADCY2,PRKD3,PDE1B,ADCY1,PRKAR2B,GNG12,RHOA,PDE1C,ADCY6,CALM1,GNGT1,AKAP13,PRKCE,AKAP7,PDE8B,GNA11,GNGT2,GNB3,ADCY9,GNAI1,ARHGEF1,AKAP12,GNAL,PPP3CC,NRAS,GNB5,PLCB3,GNG5,PDE4C,PRKAR1B,GNG13,GNB1,PDE7A,CIST1,ADCY5,GNA14,PDE4A,PRKACA,AKAP1,PRKACG,AKAP9,ADCY3,PRKCQ,PRKAR2A,PRKCH,PRKCA,AKAP10,GNG11,PRKAR1A,PRKCB,PRKCZ,ITPR1,AKAP11,PDE1A
WP244	Alpha 6 Beta 4 signaling pathway	0.0156261257560643	-4.15881103756692	35	35	0.00741997032011872	4717	5310	3908,3914,5879,8660,5580,5296,3265,2549,207,100422894,3909,3691,100616340,3918,5594,3913,387,5578,2475,5781,3911,6714,3655,5295,3912,6654,5595,5747,1978,1432,2885,3915,6464,284217,3667	LAMA2,LAMB3,RAC1,IRS2,PRKCD,PIK3R2,HRAS,GAB1,AKT1,MIR4260,LAMA3,ITGB4,MIR4758,LAMC2,MAPK1,LAMB2,RHOA,PRKCA,MTOR,PTPN11,LAMA5,SRC,ITGA6,PIK3R1,LAMB1,SOS1,MAPK3,PTK2,EIF4EBP1,MAPK14,GRB2,LAMC1,SHC1,LAMA1,IRS1
WP2431	Spinal Cord Injury	0.0158696964637016	-4.14334387104755	119	113	0.0239559041763833	4717	5310	2697,961,389,6869,3565,836,4974,63827,2353,7157,1241,5786,1875,1019,6098,56963,57556,627,729230,3576,1027,6347,2212,5173,7431,7538,1948,9475,5322,5362,1280,2670,4318,57142,3952,3558,4099,2280,3553,1956,407011,2919,1017,5530,727,983,1282,5542,5320,7099,301,2043,7040,1463,64131,4609,7124,2668,3554,9423,358,4282,3383,10673,1462,5578,7832,8741,2596,4842,1869,5594,361,9103,50507,713,4321,1464,5743,3569,3552,595,4804,50515,3627,3958,900,4050,11202,176,5925,5879,6586,1647,5803,1958,4155,199,388,387,3164,5595,3458,2920,2309,6585,65078,6403,998,383,8398,6662,9353	GJA1,CD47,RHOC,TACR1,IL4,CASP3,OMG,BCAN,FOS,TP53,LTB4R,PTPRA,E2F5,CDK4,ROS1,RGMA,SEMA6A,BDNF,CCR2,CXCL8,CDKN1B,CCL2,FCGR2A,PDYN,VIM,ZFP36,EFNB2,ROCK2,PLA2G5,PLXNA2,COL2A1,GFAP,MMP9,RTN4,LEP,IL2,MAG,FKBP1A,IL1B,EGFR,MIR23B,CXCL1,CDK2,PPP3CA,C5,CDK1,COL4A1,PRB1,PLA2G2A,TLR4,ANXA1,EPHA4,TGFB1,NCAN,XYLT1,MYC,TNF,GDNF,IL1R1,NTN1,AQP1,MIF,ICAM1,TNFSF13B,VCAN,PRKCA,BTG2,TNFSF13,GAP43,NOS1,E2F1,MAPK1,AQP4,FCGR2C,NOX4,C1QB,MMP12,CSPG4,PTGS2,IL6,IL1A,CCND1,NGFR,CHST11,CXCL10,LGALS3,CCNG1,LTB,KLK8,ACAN,RB1,RAC1,SLIT3,GADD45A,PTPRZ1,EGR1,MBP,AIF1,RHOB,RHOA,NR4A1,MAPK3,IFNG,CXCL2,FOXO3,SLIT1,RTN4R,SELP,CDC42,ARG1,PLA2G6,SOX9,SLIT2
WP2355	Corticotropin-releasing hormone signaling pathway	0.0168912901919409	-4.08095716316149	93	89	0.0188679245283019	4717	5310	6770,100506742,5970,31,2767,2355,1499,1432,10681,408,842,5563,1889,1395,5579,5594,5588,5578,3728,3848,157,9095,4846,1394,5747,5595,2783,6822,2778,2932,3283,5894,1392,4929,3713,2354,2081,3164,1583,387,3727,1589,4792,2770,10499,2784,5335,3284,5443,3576,1393,836,1584,5336,5604,2782,8061,4790,2697,6925,10411,2353,3726,409,7020,673,5908,5601,815,2776,3606,4217,7040,7099,2781,2870,2771,8912,142,5599,5584,6667,3861,5580,207,1385,3320,596,3558	STAR,CASP12,RELA,ACACA,GNA11,FOSL2,CTNNB1,MAPK14,GNB5,ARRB1,CASP9,PRKAA2,ECE1,CRHR2,PRKCB,MAPK1,PRKCQ,PRKCA,JUP,KRT1,GRK3,TBX19,NOS3,CRHR1,PTK2,MAPK3,GNB2,SULT2A1,GNAS,GSK3B,HSD3B1,RAF1,CRH,NR4A2,IVL,FOSB,ERN1,NR4A1,CYP11A1,RHOA,JUND,CYP21A2,NFKBIA,GNAI1,NCOA2,GNB3,PLCG1,HSD3B2,POMC,CXCL8,CRHBP,CASP3,CYP11B1,PLCG2,MAP2K1,GNB1,FOSL1,NFKB1,GJA1,TCF4,RAPGEF3,FOS,JUNB,ARRB2,TFAP2A,BRAF,RAP1B,MAPK9,CAMK2A,GNAQ,IL18,MAP3K5,TGFB1,TLR4,GNAZ,GRK6,GNAI2,CACNA1H,PARP1,MAPK8,PRKCI,SP1,KRT14,PRKCD,AKT1,CREB1,HSP90AA1,BCL2,IL2
WP2374	Oncostatin M Signaling Pathway	0.0169392664499152	-4.07812089353436	66	64	0.0135679457282171	4717	5310	5605,6714,4322,3091,6194,5601,3491,5595,1017,9180,5829,2475,3949,3727,1958,2185,5894,7297,3716,7422,3718,3572,5599,3845,5580,1385,207,3265,1051,6347,6777,5008,1027,6464,3667,4312,9021,1432,2885,4792,5295,6774,253260,7078,5970,5581,6654,3977,4314,5579,5594,7157,2353,5583,3726,5781,5054,5578,836,3717,5604,840,6772,4790	MAP2K2,SRC,MMP13,HIF1A,RPS6,MAPK9,CCN1,MAPK3,CDK2,OSMR,PXN,MTOR,LDLR,JUND,EGR1,PTK2B,RAF1,TYK2,JAK1,VEGFA,JAK3,IL6ST,MAPK8,KRAS,PRKCD,CREB1,AKT1,HRAS,CEBPB,CCL2,STAT5B,OSM,CDKN1B,SHC1,IRS1,MMP1,SOCS3,MAPK14,GRB2,NFKBIA,PIK3R1,STAT3,RICTOR,TIMP3,RELA,PRKCE,SOS1,LIFR,MMP3,PRKCB,MAPK1,TP53,FOS,PRKCH,JUNB,PTPN11,SERPINE1,PRKCA,CASP3,JAK2,MAP2K1,CASP7,STAT1,NFKB1
WP474	Endochondral Ossification	0.0185809441224127	-3.98561873297932	65	63	0.0133559465762137	4717	5310	11127,2247,207,1280,176,8817,6696,2260,51719,7422,579,4318,6660,871,3480,7042,801,85477,55553,5167,4208,860,1473,4322,4921,805,7040,9507,9759,864,5744,654,6662,54407,5327,1028,657,5727,8100,6772,3479,5566,5745,249,2690,655,5741,2688,4256,2737,7078,11096,1300,2261,50515,9510,3549,1515,2487,6777,5328,3481,3157	KIF3A,FGF2,AKT1,COL2A1,ACAN,FGF18,SPP1,FGFR1,CAB39,VEGFA,NKX3-2,MMP9,SOX5,SERPINH1,IGF1R,TGFB2,CALM1,SCIN,SOX6,ENPP1,MEF2C,RUNX2,CST5,MMP13,DDR2,CALM2,TGFB1,ADAMTS4,HDAC4,RUNX3,PTHLH,BMP6,SOX9,SLC38A2,PLAT,CDKN1C,BMPR1A,PTCH1,IFT88,STAT1,IGF1,PRKACA,PTH1R,ALPL,GHR,BMP7,PTH,GH1,MGP,GLI3,TIMP3,ADAMTS5,COL10A1,FGFR3,CHST11,ADAMTS1,IHH,CTSV,FRZB,STAT5B,PLAU,IGF2,HMGCS1
WP536	Calcium Regulation in the Cardiac Cell	0.0205067409898987	-3.88700161811456	151	142	0.0301038795844817	4717	5310	489,5569,2868,2869,817,109,7531,814,818,5578,844,5573,816,2791,3709,5588,5583,3708,808,5350,5579,5590,11142,64407,2767,10052,5999,57165,8786,5998,6261,115,1132,8490,2707,491,408,10681,10804,10636,8536,51764,2787,7532,779,5567,153,6546,811,54331,5577,5587,127534,801,2792,8601,2709,1131,6262,5997,154,309,2703,7534,10287,775,26575,2778,2773,2788,2783,490,2697,111,2782,155,776,7529,6547,2810,5566,5576,2702,481,777,3710,6263,3745,5581,2784,2770,5996,5331,10971,6000,2700,5575,773,7533,482,59345,3760,57369,146,114,5580,406974,486,196883,5570,480,2771,2870,2781,94235,107,6001,108,2280,1133,112,147,488,55970,148,2701,8787,815,1129,113,2706,5582,1128,3762,409,9628,805,2786,483,845,784,2776	ATP2A3,PKIA,GRK4,GRK5,CAMK2D,ADCY3,YWHAE,CAMK4,CAMK2G,PRKCA,CASQ1,PRKAR1A,CAMK2B,GNG11,ITPR2,PRKCQ,PRKCH,ITPR1,CALM3,PLN,PRKCB,PRKCZ,PKIG,RGS18,GNA11,GJC1,RGS4,GJC2,RGS11,RGS3,RYR1,ADCY9,CHRM4,RGS5,GJB3,ATP2B2,ARRB1,GNB5,GJB6,RGS14,CAMK1,GNG13,GNG5,YWHAG,CACNA1S,PRKACB,ADRB1,SLC8A1,CALR,GNG2,PRKAR2B,PRKD1,GJB4,CALM1,GNGT1,RGS20,GJB5,CHRM3,RYR2,RGS2,ADRB2,ANXA6,GJA8,YWHAZ,RGS19,CACNA1C,RGS17,GNAS,GNAI3,GNG7,GNB2,ATP2B1,GJA1,ADCY5,GNB1,ADRB3,CACNA1D,YWHAB,SLC8A3,SFN,PRKACA,PRKAR2A,GJA5,ATP1B1,CACNA1E,ITPR3,RYR3,KCNB1,PRKCE,GNB3,GNAI1,RGS1,PLCB3,YWHAQ,RGS7,GJA3,PRKAR1B,CACNA1A,YWHAH,ATP1B2,GNB4,KCNJ3,GJD2,ADRA1D,ADCY8,PRKCD,MIR197,FXYD2,ADCY4,PKIB,ATP1A4,GNAI2,GRK6,GNAZ,GNG8,ADCY1,RGS10,ADCY2,FKBP1A,CHRM5,ADCY6,ADRA1B,ATP2A2,GNG12,ADRA1A,GJA4,RGS9,CAMK2A,CHRM2,ADCY7,GJB2,PRKCG,CHRM1,KCNJ5,ARRB2,RGS6,CALM2,GNG4,ATP1B3,CASQ2,CACNB3,GNAQ
WP706	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways	0.0211786613933897	-3.85476114225142	162	152	0.0322238711045156	4717	5310	4803,7124,5979,5978,864,720,6550,1143,3570,79923,1746,6752,5087,3091,3359,1129,1103,4208,4791,5316,1139,3784,291,7434,116,1644,2033,2597,2624,3553,7422,1385,6667,6750,117,3764,3576,5575,3725,1051,3586,2908,2019,7533,1374,478,4915,627,10971,2645,406992,5452,23171,2784,7166,2625,3280,6751,3757,406919,4904,7161,5454,6507,4010,1137,55800,3557,5576,6869,7529,836,10522,121278,5566,4790,2697,6863,133522,859,100500842,8553,10664,2554,3030,401,9722,11076,5460,6331,2538,7534,2328,7018,551,1390,3596,8929,3356,6262,9734,6616,3032,54862,30012,1958,5577,54738,6844,5567,6640,6670,4760,7532,1141,5053,4821,6929,1499,34,7068,6657,4133,3065,3350,55536,4800,4150,226,3569,1387,3552,2100,10891,388585,4824,3329,7054,429,361,5573,6532,7433,89832,7531,6330,100302237,6711,4602,1889,4152,6095	NGF,TNF,RET,REST,RUNX3,C4A,SLC9A3,CHRNB4,IL6R,NANOG,DLX2,SSTR2,PBX1,HIF1A,HTR3A,CHRM2,CHAT,MEF2C,NFKB2,PKNOX1,CHRNA7,KCNQ1,SLC25A4,VIPR2,ADCYAP1,DDC,EP300,GAPDH,GATA2,IL1B,VEGFA,CREB1,SP1,SST,ADCYAP1R1,KCNJ8,CXCL8,PRKAR1B,JUN,CEBPB,IL10,NR3C1,EN1,YWHAH,CPT1A,ATP1A3,NTRK2,BDNF,YWHAQ,GCK,MIR210,POU2F2,GPD1L,GNB3,TPH1,GATA3,HES1,SSTR1,KCNH2,MIR130A,YBX1,TP73,POU3F2,SLC1A3,LMX1B,CHRNA4,SCN3B,IL1RN,PRKAR2A,TACR1,YWHAB,CASP3,DEAF1,TPH2,PRKACA,NFKB1,GJA1,TAC1,PPARGC1B,CAV3,MIR3652,BHLHE40,CTCF,GABRA1,HADHA,PHOX2A,NOS1AP,TPPP,POU5F1,SCN5A,G6PC1,YWHAZ,FMO3,TF,AVP,CREM,IL13,PHOX2B,HTR2A,RYR2,HDAC9,SNAP25,HADHB,CC2D1A,TLX3,EGR1,PRKAR2B,FEV,VAMP2,PRKACB,SNTA1,SP3,NEUROD1,YWHAG,CHRNB2,PAH,NKX2-2,TCF3,CTNNB1,ACADM,THRB,SOX2,MAP2,HDAC1,HTR1A,CDCA7L,NFYA,MAZ,ALDOA,IL6,CREBBP,IL1A,ESR2,PPARGC1A,HES5,NKX3-1,HSPD1,TH,ASCL1,AQP4,PRKAR1A,SLC6A4,VIPR1,CHRFAM7A,YWHAE,SCN4B,MIR1281,SPTBN1,MYB,ECE1,MBD1,RORA
WP437	EGF/EGFR Signaling Pathway	0.0211786613933897	-3.85476114225142	162	152	0.0322238711045156	4717	5310	6812,9138,9712,5295,83737,84867,160,6774,8202,7409,10928,5900,1432,4216,5728,2064,51196,6196,2060,5338,6772,5296,3717,6311,5607,6456,6195,2059,5578,1072,4215,5590,5579,5594,1869,163,5287,4214,5747,5906,9610,6714,5170,9564,4846,3925,2308,8027,9846,998,3985,6776,4734,2354,5058,382,5337,1445,2549,5894,2185,5111,4205,5596,2005,5879,10188,10254,2475,4605,3727,5921,5868,1175,8826,9047,2887,9922,858,857,54206,6654,58513,51079,9101,7837,253260,5335,6464,1398,11184,2885,7410,7291,3725,1978,6198,6777,10451,1950,5604,2697,1759,29924,9146,2353,5781,5899,9046,5898,23624,8867,4208,5601,5801,3635,10253,4690,815,673,4209,10006,6790,868,1173,50807,867,8440,5605,9252,25,10746,5599,5584,3845,10617,6667,5580,207,5359,466,1385,3265,3636,3716,5037,5598,5753,1956,6457,5782,6655	STXBP1,ARHGEF1,USP6NL,PIK3R1,ITCH,PTPN5,AP2A1,STAT3,NCOA3,VAV1,RALBP1,RALGDS,MAPK14,MAP3K4,PTEN,ERBB2,PLCE1,RPS6KA2,EPS15,PLD2,STAT1,PIK3R2,JAK2,ATXN2,MAP2K5,SH3GL2,RPS6KA1,EPS8,PRKCA,CFL1,MAP3K3,PRKCZ,PRKCB,MAPK1,E2F1,AP2B1,PIK3C2B,MAP3K1,PTK2,RAP1A,RIN1,SRC,PDPK1,BCAR1,NOS3,STMN1,FOXO1,STAM,GAB2,CDC42,LIMK2,STAT5A,NEDD4,FOSB,PAK1,ARF6,PLD1,CSK,GAB1,RAF1,PTK2B,PCNA,MEF2A,MAPK4,ELK4,RAC1,TNK2,STAM2,MTOR,MYBL2,JUND,RASA1,RAB5A,AP2S1,IQGAP1,SH2D2A,GRB10,IQSEC1,CAV2,CAV1,ERRFI1,SOS1,EPS15L1,NDUFA13,USP8,PXDN,RICTOR,PLCG1,SHC1,CRK,MAP4K1,GRB2,VAV2,TWIST1,JUN,EIF4EBP1,RPS6KB1,STAT5B,VAV3,EGF,MAP2K1,GJA1,DNM1,EPN1,HGS,FOS,PTPN11,RALB,DOK2,RALA,CBLC,SYNJ1,MEF2C,MAPK9,PTPRR,INPP5D,SPRY2,NCK1,CAMK2A,BRAF,MEF2D,ABI1,AURKA,CBLB,AP2M1,ASAP1,CBL,NCK2,MAP2K2,RPS6KA5,ABL1,MAP3K2,MAPK8,PRKCI,KRAS,STAMBP,SP1,PRKCD,AKT1,PLSCR1,ATF1,CREB1,HRAS,INPPL1,JAK1,PEBP1,MAPK7,PTK6,EGFR,SH3GL3,PTPN12,SOS2
WP410	Diurnally Regulated Genes with Circadian Orthologs	0.021211279857488	-3.85322217005312	49	48	0.0101759592961628	4717	5310	1408,23118,5187,7360,26059,50486,9975,10787,5281,3422,2947,5685,5516,7122,9444,5507,1982,2674,11030,8987,3312,1407,8031,7352,1051,10946,10140,6612,687,51582,4618,2120,9218,3301,406,11335,2950,51663,8341,7341,9802,694,3108,5813,9709,9575,8864,10381	CRY2,TAB2,PER1,UGP2,ERC2,G0S2,NR1D2,NCKAP1,PIGF,IDI1,GSTM3,PSMA4,PPP2CB,CLDN5,QKI,PPP1R3C,EIF4G2,GFRA1,RBPMS,STBD1,HSPA8,CRY1,NCOA4,UCP3,CEBPB,SF3A3,TOB1,SUMO3,KLF9,AZIN1,MYF6,ETV6,VAPA,DNAJA1,BMAL1,CBX3,GSTP1,ZFR,H2BC15,SUMO1,DAZAP2,BTG1,HLA-DMA,PURA,HERPUD1,CLOCK,PER2,TUBB3
WP710	DNA Damage Response (only ATM dependent)	0.0227722983891891	-3.78221046464219	114	108	0.0228959084163663	4717	5310	5529,6342,5296,4088,5934,4089,578,356,30849,3146,847,5594,5287,8312,89780,23533,595,7473,5295,6885,4216,4893,5291,581,3667,80326,5328,1499,2064,5728,27113,324,604,894,5879,5527,1855,5290,5294,5289,896,5288,387,1856,4214,2309,3643,7477,2538,901,998,10000,51176,2932,1026,8061,4790,8503,7475,5293,81029,5880,7157,7481,51384,7161,7471,6648,5163,6654,1857,472,7476,5602,2885,10018,6464,3725,5366,10023,1027,3265,207,5599,3845,208,54361,638,4193,7482,7472,3949,6655,6934,5286,596,83439,4791,5601,5881,6932,1029,4609,7040,25,197259,7474,7480	PPP2R5E,SCP2,PIK3R2,SMAD3,RBL2,SMAD4,BAK1,FASLG,PIK3R4,HMGB1,CAT,MAPK1,PIK3C2B,AXIN1,WNT3A,PIK3R5,CCND1,WNT3,PIK3R1,MAP3K7,MAP3K4,NRAS,PIK3CB,BAX,IRS1,WNT10A,PLAU,CTNNB1,ERBB2,PTEN,BBC3,APC,BCL6,CCND2,RAC1,PPP2R5C,DVL1,PIK3CA,PIK3CG,PIK3C3,CCND3,PIK3C2G,RHOA,DVL2,MAP3K1,FOXO3,INSR,WNT7B,G6PC1,CCNG2,CDC42,AKT3,LEF1,GSK3B,CDKN1A,FOSL1,NFKB1,PIK3R3,WNT6,PIK3CD,WNT5B,RAC2,TP53,WNT11,WNT16,TP73,WNT1,SOD2,PDK1,SOS1,DVL3,ATM,WNT7A,MAPK10,GRB2,BCL2L11,SHC1,JUN,PMAIP1,FRAT1,CDKN1B,HRAS,AKT1,MAPK8,KRAS,AKT2,WNT4,BIK,MDM2,WNT2B,WNT2,LDLR,SOS2,TCF7L2,PIK3C2A,BCL2,TCF7L1,NFKB2,MAPK9,RAC3,TCF7,CDKN2A,MYC,TGFB1,ABL1,MLKL,WNT5A,WNT10B
WP51	Regulation of Actin Cytoskeleton	0.0232920721202917	-3.75964222865744	149	140	0.0296798812804749	4717	5310	56924,5747,1131,5595,2768,9564,10787,2256,27006,4342,10152,998,1729,10297,2255,5058,28964,2247,324,1445,5894,5062,5596,5879,5294,5829,5289,5290,2934,2251,5159,387,8826,5288,8822,23533,50649,22808,9138,5295,1132,5291,7409,54961,4632,4893,2254,7429,2250,10298,929,55845,5296,2248,2249,3984,4659,2252,30849,87,5962,85464,8874,2263,1072,5594,4634,5287,1073,2259,1129,6237,1128,2253,673,2149,9965,79837,4628,5881,2335,8396,5605,8074,5155,26291,10672,8817,3845,60,6548,2264,26281,2260,4638,1956,1133,8936,5156,8395,5286,7430,55970,6655,81624,54434,2147,6654,2257,2261,8394,624,1398,57144,2909,1793,9475,10458,138429,7414,1950,2246,8045,10092,5604,5293,5154,71,8503,22800,26999,5597,10163,623,55740,5880,3672,5216,5305,23396	PAK6,PTK2,CHRM3,MAPK3,GNA12,BCAR1,NCKAP1,FGF11,FGF22,MOS,ABI2,CDC42,DIAPH1,APC2,FGF10,PAK1,GIT1,FGF2,APC,CSK,RAF1,PAK2,MAPK4,RAC1,PIK3CG,PXN,PIK3C3,PIK3CA,GSN,FGF6,PDGFRB,RHOA,IQGAP1,PIK3C2G,FGF17,PIK3R5,ARHGEF4,MRAS,ARHGEF1,PIK3R1,CHRM4,PIK3CB,VAV1,SSH3,MYL1,NRAS,FGF9,VIL1,FGF5,PAK4,CD14,BRK1,PIK3R2,FGF3,FGF4,LIMK1,PPP1R12A,FGF7,PIK3R4,ACTN1,RDX,SSH2,ARHGEF7,FGFR2,CFL1,MAPK1,MYL3,PIK3C2B,CFL2,FGF14,CHRM2,RRAS,CHRM1,FGF8,BRAF,F2R,FGF19,PIP4K2C,MYH10,RAC3,FN1,PIP4K2B,MAP2K2,FGF23,PDGFB,FGF21,GNA13,FGF18,KRAS,ACTB,SLC9A1,FGFR4,FGF20,FGFR1,MYLK,EGFR,CHRM5,WASF1,PDGFRA,PIP5K1B,PIK3C2A,EZR,GNG12,SOS2,DIAPH3,SSH1,F2,SOS1,FGF12,FGFR3,PIP5K1A,BDKRB2,CRK,PAK5,ARHGAP35,DOCK1,ROCK2,BAIAP2,PIP5KL1,VCL,EGF,FGF1,RASSF7,ARPC5,MAP2K1,PIK3CD,PDGFA,ACTG1,PIK3R3,RRAS2,CYFIP2,MAPK6,WASF2,BDKRB1,ENAH,RAC2,ITGA1,PFN1,PIP4K2A,PIP5K1C
WP3850	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling	0.0251716288977383	-3.68203775608708	31	31	0.00657197371210515	4717	5310	3488,5337,4790,207,4088,4087,3479,3611,3480,5564,4703,51528,5294,2660,2475,3688,84557,7132,5163,8892,10891,93,6198,1977,5728,8976,8744,2932,84676,114907,3667	IGFBP5,PLD1,NFKB1,AKT1,SMAD3,SMAD2,IGF1,ILK,IGF1R,PRKAB1,NEB,JKAMP,PIK3CG,MSTN,MTOR,ITGB1,MAP1LC3A,TNFRSF1A,PDK1,EIF2B2,PPARGC1A,ACVR2B,RPS6KB1,EIF4E,PTEN,WASL,TNFSF9,GSK3B,TRIM63,FBXO32,IRS1
WP2870	Extracellular vesicle-mediated signaling in recipient cells	0.0283563474675217	-3.56290437730786	30	30	0.00635997456010176	4717	5310	8312,7042,2475,1956,4233,7039,5894,27121,4089,3845,4087,4088,324,207,3265,8842,3082,2064,7474,1499,7040,4893,7049,7046,7103,23533,89780,7043,4240,7048	AXIN1,TGFB2,MTOR,EGFR,MET,TGFA,RAF1,DKK4,SMAD4,KRAS,SMAD2,SMAD3,APC,AKT1,HRAS,PROM1,HGF,ERBB2,WNT5A,CTNNB1,TGFB1,NRAS,TGFBR3,TGFBR1,TSPAN8,PIK3R5,WNT3A,TGFB3,MFGE8,TGFBR2
WP2855	Dopaminergic Neurogenesis	0.0283563474675217	-3.56290437730786	30	30	0.00635997456010176	4717	5310	6774,6469,2253,6571,1028,5309,2019,2020,5979,2637,6657,7040,2735,4929,4487,216,3170,4760,5015,4821,4009,2736,7054,429,6531,4825,7471,1644,4010,63973	STAT3,SHH,FGF8,SLC18A2,CDKN1C,PITX3,EN1,EN2,RET,GBX2,SOX2,TGFB1,GLI1,NR4A2,MSX1,ALDH1A1,FOXA2,NEUROD1,OTX2,NKX2-2,LMX1A,GLI2,TH,ASCL1,SLC6A3,NKX6-1,WNT1,DDC,LMX1B,NEUROG2
WP28	Selenium Metabolism and Selenoproteins	0.0287437490940215	-3.54933495819519	46	45	0.00953996184015264	4717	5310	51714,6156,6670,1733,7296,54938,79048,348303,1491,257202,4790,10587,6667,2878,1734,2877,8991,118672,4780,60678,58515,6301,2876,51540,2353,2879,22928,6415,83642,51091,55829,54952,6414,114112,5970,22929,1735,1390,140606,57190,5451,51734,2168,3725,280636	SELENOT,RPL30,SP3,DIO1,TXNRD1,SARS2,SECISBP2,SELENOV,CTH,GPX6,NFKB1,TXNRD2,SP1,GPX3,DIO2,GPX2,SELENBP1,PSTK,NFE2L2,EEFSEC,SELENOK,SARS1,GPX1,SCLY,FOS,GPX4,SEPHS2,SELENOW,SELENOO,SEPSECS,SELENOS,TRNAU1AP,SELENOP,TXNRD3,RELA,SEPHS1,DIO3,CREM,SELENOM,SELENON,POU2F1,MSRB1,FABP1,JUN,SELENOH
WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway	0.0318192743394701	-3.44768306150318	144	135	0.0286198855204579	4717	5310	4208,5601,653361,4690,4905,815,5923,4688,650,7074,8440,5562,5605,4082,5515,9252,4803,1977,23191,10746,6696,5599,5580,32,1385,207,8878,3265,8894,5598,4914,10048,10817,57498,7249,10818,25759,4792,5602,391,23373,2562,5335,10018,6464,1147,627,2885,4915,7410,2534,3725,1978,3781,6198,6777,10451,6868,5604,25970,4790,5864,836,10399,2353,5781,1938,4916,8851,399694,10603,4904,4214,3551,2309,5906,5595,6714,5170,2904,55816,6194,2891,2932,998,4137,6776,6272,1457,324,1739,5894,2185,23426,4205,4908,5879,10642,2475,1958,53358,1959,1000,5970,4804,1020,84894,5295,3738,6774,8536,3667,1432,4684,7189,1499,5792,6772,5296,814,1268,4776,5563,3717,1965,8660,5607,249,6195,2890,1072,1808,5594,140885,1795	MEF2C,MAPK9,NCF1,NCK1,NSF,CAMK2A,RASGRF1,NCF2,BMP2,TIAM1,NCK2,PRKAA1,MAP2K2,MARCKS,PPP2CA,RPS6KA5,NGF,EIF4E,CYFIP1,MAP3K2,SPP1,MAPK8,PRKCD,ACACB,CREB1,AKT1,SQSTM1,HRAS,EIF2S2,MAPK7,NTRK1,RANBP9,FRS3,KIDINS220,TSC2,FRS2,SHC2,NFKBIA,MAPK10,RHOG,CRTC1,GABRB3,PLCG1,BCL2L11,SHC1,CHUK,BDNF,GRB2,NTRK2,VAV2,FYN,JUN,EIF4EBP1,KCNN2,RPS6KB1,STAT5B,VAV3,ADAM17,MAP2K1,SH2B1,NFKB1,RAB3A,CASP3,RACK1,FOS,PTPN11,EEF2,NTRK3,CDK5R1,SHC4,SH2B2,YBX1,MAP3K1,IKBKB,FOXO3,RAP1A,MAPK3,SRC,PDPK1,GRIN2B,DOK5,RPS6,GRIA2,GSK3B,CDC42,MAPT,STAT5A,SORT1,CSNK2A1,APC,DLG1,RAF1,PTK2B,GRIP1,MEF2A,NTF3,RAC1,IGF2BP1,MTOR,EGR1,SHC3,EGR2,CDH2,RELA,NGFR,CDK5,LINGO1,PIK3R1,KCNA3,STAT3,CAMK1,IRS1,MAPK14,NCAM1,TRAF6,CTNNB1,PTPRF,STAT1,PIK3R2,CAMK4,CNR1,NFATC4,PRKAA2,JAK2,EIF2S1,IRS2,MAP2K5,ALPL,RPS6KA1,GRIA1,CFL1,DPYSL2,MAPK1,SIRPA,DOCK3
WP1984	Integrated Breast Cancer Pathway	0.0343473291523258	-3.37123101727197	154	144	0.0305278778884884	4717	5310	595,27145,4664,675,659,4361,221002,7048,2099,4092,2931,5728,10913,1499,8202,3667,581,4312,3065,60489,79902,1263,641,100302237,842,4089,1111,1453,8438,23411,28996,5569,5296,6772,1022,25780,4149,5594,1869,79027,578,29124,11200,6009,2308,4091,23613,580,5347,5906,10600,27005,545,140739,57223,994,998,1647,10454,5879,4087,4661,5925,5058,8846,5888,2896,8772,1588,2475,841,6597,993,571,8554,999,1019,9958,4436,7035,23077,472,7046,8717,9175,84640,80271,3725,1605,4953,1147,79877,2241,64781,152789,836,57820,5284,55671,8061,4790,4086,7517,5898,7465,7175,7157,5371,4763,196,673,6010,56911,1017,6237,100379661,657,3156,25,6790,4609,5245,6794,301,3716,4193,55526,7422,2956,3845,6667,1385,207,466,10111,596,7249,253959,1956,3612,57178,7248,2033,672	CCND1,FILIP1,NAB1,BRCA2,BMPR2,MRE11,RASGEF1A,TGFBR2,ESR1,SMAD7,GSK3A,PTEN,EDAR,CTNNB1,NCOA3,IRS1,BAX,MMP1,HDAC1,APOBEC3G,NUP85,PLK3,BLM,MIR1281,CASP9,SMAD4,CHEK1,CSNK1D,RAD54L,SIRT1,HIPK2,PKIA,PIK3R2,STAT1,CDK7,RASGRP3,MAX,MAPK1,E2F1,ZNF655,BAK1,LGALS13,CHEK2,RHEB,FOXO1,SMAD6,ZMYND8,BARD1,PLK1,RAP1A,USP16,USP21,ATR,UBE2F,PPP4R3B,CDC25B,CDC42,GADD45A,TAB1,RAC1,SMAD2,MYT1,RB1,PAK1,ALKBH1,RAD51,GRN,FADD,CYP19A1,MTOR,CASP8,SMARCA4,CDC25A,BACH1,PIAS1,CDH1,CDK4,USP15,MSH2,TFPI,MYCBP2,ATM,TGFBR1,TRADD,MAP3K13,USP38,ITPKC,JUN,DAG1,ODC1,CHUK,DCAKD,FER,CERK,JAKMIP1,CASP3,CCNB1IP1,PIGR,PPP4R3A,FOSL1,NFKB1,SMAD1,XRCC3,RALA,WEE1,TPR,TP53,PML,NF1,AHR,BRAF,RHO,MAP3K7CL,CDK2,RRAS,GRIK1-AS2,BMPR1A,HMGCR,ABL1,AURKA,MYC,PHB1,STK11,ANXA1,JAK1,MDM2,DHTKD1,VEGFA,MSH6,KRAS,SP1,CREB1,AKT1,ATF1,RAD50,BCL2,TSC2,RALGAPA1,EGFR,IMPA1,ZMIZ1,TSC1,EP300,BRCA1
WP2035	Follicle Stimulating Hormone (FSH) signaling pathway	0.0405326301568879	-3.20564794637176	27	27	0.00572397710409158	4717	5310	7249,2492,1588,26060,5594,2475,8290,5578,1081,5894,5566,2870,207,1385,6446,374,2488,1978,6198,6199,627,1432,6009,6714,2308,6194,5595	TSC2,FSHR,CYP19A1,APPL1,MAPK1,MTOR,H3-4,PRKCA,CGA,RAF1,PRKACA,GRK6,AKT1,CREB1,SGK1,AREG,FSHB,EIF4EBP1,RPS6KB1,RPS6KB2,BDNF,MAPK14,RHEB,SRC,FOXO1,RPS6,MAPK3
WP179	Cell Cycle	0.0425101189459442	-3.15801313854562	105	99	0.0209879160483358	4717	5310	4193,4254,699,4174,55388,9184,1874,1870,8555,5933,375,51564,2033,4172,983,8318,1017,9134,25,8556,7040,1029,1876,7529,4999,4998,23594,7465,995,7157,8379,4085,999,1019,1875,472,8317,4171,84515,7533,4175,1871,1027,8900,10971,1647,5111,1021,5925,10014,898,7532,894,11138,324,4221,23595,219972,896,701,890,254394,993,9700,11200,5000,7534,26255,5347,990,1026,545,5591,7027,140739,2932,8841,9759,994,100302237,7531,10926,10459,4089,5001,1111,4088,891,3066,1869,9088,4173,9133,6502,902,10744,3065,9232,991	MDM2,KITLG,BUB1,MCM5,MCM10,BUB3,E2F4,E2F2,CDC14B,RBL1,ARF1,HDAC7,EP300,MCM3,CDK1,CDC45,CDK2,CCNE2,ABL1,CDC14A,TGFB1,CDKN2A,E2F6,YWHAB,ORC2,ORC1,ORC6,WEE1,CDC25C,TP53,MAD1L1,MAD2L1,CDH1,CDK4,E2F5,ATM,CDC7,MCM2,MCM8,YWHAH,MCM6,E2F3,CDKN1B,CCNA1,YWHAQ,GADD45A,PCNA,CDK6,RB1,HDAC5,CCNE1,YWHAG,CCND2,TBC1D8,APC,MEN1,ORC3,MPEG1,CCND3,BUB1B,CCNA2,MCM9,CDC25A,ESPL1,CHEK2,ORC4,YWHAZ,PTTG3P,PLK1,CDC6,CDKN1A,ATR,PRKDC,TFDP1,UBE2F,GSK3B,HDAC3,HDAC4,CDC25B,MIR1281,YWHAE,DBF4,MAD2L2,SMAD4,ORC5,CHEK1,SMAD3,CCNB1,HDAC2,E2F1,PKMYT1,MCM4,CCNB2,SKP2,CCNH,PTTG2,HDAC1,PTTG1,CDC20
WP581	EPO Receptor Signaling	0.0456564523020623	-3.0866103390581	26	26	0.00551197795208819	4717	5310	6777,6776,5605,10076,2885,3667,6464,6774,6714,5595,6654,5163,5788,5594,2056,2057,5921,8651,5294,8660,3717,1154,5894,207,6772,5604	STAT5B,STAT5A,MAP2K2,PTPRU,GRB2,IRS1,SHC1,STAT3,SRC,MAPK3,SOS1,PDK1,PTPRC,MAPK1,EPO,EPOR,RASA1,SOCS1,PIK3CG,IRS2,JAK2,CISH,RAF1,AKT1,STAT1,MAP2K1
WP26	Signal Transduction of S1P Receptor	0.0456564523020623	-3.0866103390581	26	26	0.00551197795208819	4717	5310	6300,2773,5331,53637,10000,2770,1903,23236,9294,5595,56848,1901,5594,29127,5287,5330,5596,6610,5597,5598,2771,427,208,406974,207,8877	MAPK12,GNAI3,PLCB3,S1PR5,AKT3,GNAI1,S1PR3,PLCB1,S1PR2,MAPK3,SPHK2,S1PR1,MAPK1,RACGAP1,PIK3C2B,PLCB2,MAPK4,SMPD2,MAPK6,MAPK7,GNAI2,ASAH1,AKT2,MIR197,AKT1,SPHK1
WP2878	PPAR Alpha Pathway	0.0456564523020623	-3.0866103390581	26	26	0.00551197795208819	4717	5310	6256,1376,5360,1622,1019,1581,595,10062,6342,1582,983,336,2168,1962,34,376497,54600,1374,30,116519,335,55554,345,4609,5465,1579	RXRA,CPT2,PLTP,DBI,CDK4,CYP7A1,CCND1,NR1H3,SCP2,CYP8B1,CDK1,APOA2,FABP1,EHHADH,ACADM,SLC27A1,UGT1A9,CPT1A,ACAA1,APOA5,APOA1,KLK15,APOC3,MYC,PPARA,CYP4A11
WP2018	RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway	0.0457845341162871	-3.08380892794026	55	53	0.0112359550561798	4717	5310	207,8878,5971,208,5599,5879,10454,9060,2475,5608,2274,5609,4067,5595,3551,5601,5747,4791,6714,867,4286,998,4772,7187,9846,23118,5296,4790,6772,5604,8600,8792,3383,7412,54,2353,799,5594,1513,6688,7185,6850,4982,5970,5335,5295,4792,6885,1432,1147,7188,7189,3725	AKT1,SQSTM1,RELB,AKT2,MAPK8,RAC1,TAB1,PAPSS2,MTOR,MAP2K6,FHL2,MAP2K7,LYN,MAPK3,IKBKB,MAPK9,PTK2,NFKB2,SRC,CBL,MITF,CDC42,NFATC1,TRAF3,GAB2,TAB2,PIK3R2,NFKB1,STAT1,MAP2K1,TNFSF11,TNFRSF11A,ICAM1,VCAM1,ACP5,FOS,CALCR,MAPK1,CTSK,SPI1,TRAF1,SYK,TNFRSF11B,RELA,PLCG1,PIK3R1,NFKBIA,MAP3K7,MAPK14,CHUK,TRAF5,TRAF6,JUN
WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer	0.0499760554184301	-2.99621127989061	54	52	0.0110239559041764	4717	5310	8795,3084,3070,3727,602,2065,207,8878,2081,5062,351,2185,27242,10276,1728,8767,7124,1026,25,3315,5747,2149,2729,3575,8870,3309,8312,1495,7185,26135,8065,8454,79092,5594,3329,10451,8531,4790,840,7057,9616,308,3065,9021,5585,1027,7431,6198,348,2113,332,4092	TNFRSF10B,NRG1,HELLS,JUND,BCL3,ERBB3,AKT1,SQSTM1,ERN1,PAK2,APP,PTK2B,TNFRSF21,NET1,NQO1,RIPK2,TNF,CDKN1A,ABL1,HSPB1,PTK2,F2R,GCLC,IL7R,IER3,HSPA5,AXIN1,CTNNA1,TRAF1,SERBP1,CUL5,CUL1,CARD14,MAPK1,HSPD1,VAV3,YBX3,NFKB1,CASP7,THBS1,RNF7,ANXA5,HDAC1,SOCS3,PKN1,CDKN1B,VIM,RPS6KB1,APOE,ETS1,BIRC5,SMAD7
WP1528	Physiological and Pathological Hypertrophy  of the Heart	0.0514267584013136	-2.9675966505165	25	25	0.0052999788000848	4717	5310	2353,5606,5579,387,3977,183,801,5594,5599,3572,5600,2626,5532,5879,817,4776,805,1432,50804,3725,5581,1489,5530,6774,1906	FOS,MAP2K3,PRKCB,RHOA,LIFR,AGT,CALM1,MAPK1,MAPK8,IL6ST,MAPK11,GATA4,PPP3CB,RAC1,CAMK2D,NFATC4,CALM2,MAPK14,MYEF2,JUN,PRKCE,CTF1,PPP3CA,STAT3,EDN1
WP2895	Differentiation of white and brown adipocyte	0.0514267584013136	-2.9675966505165	25	25	0.0052999788000848	4717	5310	23090,7545,253738,133522,1149,1051,3224,5468,56301,10891,652,51316,650,10205,63976,655,1050,4093,1054,4086,9370,27129,3225,4090,3952	ZNF423,ZIC1,EBF3,PPARGC1B,CIDEA,CEBPB,HOXC8,PPARG,SLC7A10,PPARGC1A,BMP4,PLAC8,BMP2,MPZL2,PRDM16,BMP7,CEBPA,SMAD9,CEBPG,SMAD1,ADIPOQ,HSPB7,HOXC9,SMAD5,LEP
WP2406	Cardiac Progenitor Differentiation	0.0545227091857234	-2.90913798179405	53	51	0.010811956752173	4717	5310	6656,2932,7040,7070,5080,6862,4208,3791,652,64321,6331,79923,5460,83881,91807,5156,3084,7852,389421,9241,2247,3170,4838,4633,1432,6657,22943,3481,6910,4684,3670,50805,3624,89780,4624,4920,55897,70,649,1482,57057,3630,132625,140885,145873,7139,3815,3479,2626,79727,290	SOX1,GSK3B,TGFB1,THY1,PAX6,TBXT,MEF2C,KDR,BMP4,SOX17,SCN5A,NANOG,POU5F1,MIXL1,MYLK3,PDGFRA,NRG1,CXCR4,LIN28B,NOG,FGF2,FOXA2,NODAL,MYL2,MAPK14,SOX2,DKK1,IGF2,TBX5,NCAM1,ISL1,IRX4,INHBA,WNT3A,MYH6,ROR2,MESP1,ACTC1,BMP1,NKX2-5,TBX20,INS,ZFP42,SIRPA,MESP2,TNNT2,KIT,IGF1,GATA4,LIN28A,ANPEP
WP3658	Wnt/beta-catenin Signaling Pathway in Leukemia	0.057924961625074	-2.84860687115724	24	24	0.00508797964808141	4717	5310	607,207,324,7471,2322,5371,3728,4040,57167,595,7704,5914,8313,1452,26108,22943,5467,8323,6929,1499,11197,4041,2932,51176	BCL9,AKT1,APC,WNT1,FLT3,PML,JUP,LRP6,SALL4,CCND1,ZBTB16,RARA,AXIN2,CSNK1A1,PYGO1,DKK1,PPARD,FZD6,TCF3,CTNNB1,WIF1,LRP5,GSK3B,LEF1
WP1539	Angiogenesis	0.057924961625074	-2.84860687115724	24	24	0.00508797964808141	4717	5310	405,2263,5594,5155,7010,5156,1432,2321,5290,284,6714,4318,4846,1387,3091,5335,7422,7078,7077,5747,3791,4086,207,2247	ARNT,FGFR2,MAPK1,PDGFB,TEK,PDGFRA,MAPK14,FLT1,PIK3CA,ANGPT1,SRC,MMP9,NOS3,CREBBP,HIF1A,PLCG1,VEGFA,TIMP3,TIMP2,PTK2,KDR,SMAD1,AKT1,FGF2
WP2034	Leptin signaling pathway	0.0623352026998888	-2.77522896140756	76	72	0.0152639389442442	4717	5310	5604,25970,5336,5296,4790,6772,5563,30837,3717,3557,5781,6195,5594,5970,31,6654,2099,595,5295,5335,6774,6464,581,3953,1147,3667,1432,9021,2885,2064,9475,2931,5728,2534,1978,6198,3840,6777,5599,8648,6667,3265,598,1385,32,207,3716,8835,5894,3952,1154,5879,3553,2475,387,10657,5747,1073,3551,5595,6714,5966,5140,4846,6194,2308,2932,5770,998,5562,5605,1977	MAP2K1,SH2B1,PLCG2,PIK3R2,NFKB1,STAT1,PRKAA2,SOCS7,JAK2,IL1RN,PTPN11,RPS6KA1,MAPK1,RELA,ACACA,SOS1,ESR1,CCND1,PIK3R1,PLCG1,STAT3,SHC1,BAX,LEPR,CHUK,IRS1,MAPK14,SOCS3,GRB2,ERBB2,ROCK2,GSK3A,PTEN,FYN,EIF4EBP1,RPS6KB1,KPNA4,STAT5B,MAPK8,NCOA1,SP1,HRAS,BCL2L1,CREB1,ACACB,AKT1,JAK1,SOCS2,RAF1,LEP,CISH,RAC1,IL1B,MTOR,RHOA,KHDRBS1,PTK2,CFL2,IKBKB,MAPK3,SRC,REL,PDE3B,NOS3,RPS6,FOXO1,GSK3B,PTPN1,CDC42,PRKAA1,MAP2K2,EIF4E
WP2526	PDGF Pathway	0.0635321255228787	-2.75620958726858	38	37	0.0078439686241255	4717	5310	5159,6722,5921,387,5594,2353,5781,3716,5894,5879,5321,5599,5604,5058,5154,3265,6772,7410,6416,3725,23647,5155,6464,7074,7409,1147,998,2885,8976,6714,4792,5295,5335,6774,4214,6654,5595	PDGFRB,SRF,RASA1,RHOA,MAPK1,FOS,PTPN11,JAK1,RAF1,RAC1,PLA2G4A,MAPK8,MAP2K1,PAK1,PDGFA,HRAS,STAT1,VAV2,MAP2K4,JUN,ARFIP2,PDGFB,SHC1,TIAM1,VAV1,CHUK,CDC42,GRB2,WASL,SRC,NFKBIA,PIK3R1,PLCG1,STAT3,MAP3K1,SOS1,MAPK3
WP3646	Hepatitis C and Hepatocellular Carcinoma	0.0647884468566448	-2.73662798076863	51	49	0.0103879584481662	4717	5310	1432,2885,6241,4312,3725,2487,3576,7410,332,6654,5743,7046,3569,6774,330,595,356,5781,7157,840,4790,7345,4088,842,4089,836,51176,2017,7040,6927,4609,1026,3577,5595,26509,3091,3570,5420,84909,960,672,1870,1284,207,598,5599,7422,5879,3716	MAPK14,GRB2,RRM2,MMP1,JUN,FRZB,CXCL8,VAV2,BIRC5,SOS1,PTGS2,TGFBR1,IL6,STAT3,BIRC3,CCND1,FASLG,PTPN11,TP53,CASP7,NFKB1,UCHL1,SMAD3,CASP9,SMAD4,CASP3,LEF1,CTTN,TGFB1,HNF1A,MYC,CDKN1A,CXCR1,MAPK3,MYOF,HIF1A,IL6R,PODXL,AOPEP,CD44,BRCA1,E2F2,COL4A2,AKT1,BCL2L1,MAPK8,VEGFA,RAC1,JAK1
WP23	B Cell Receptor Signaling Pathway	0.0673464230772223	-2.69790548700572	98	92	0.0195039219843121	4717	5310	5777,3551,3059,2308,6452,5966,5170,998,9846,2932,3608,29760,2549,604,5879,5596,975,5894,5608,5294,4067,640,5970,5788,4775,5295,1432,6885,7409,2931,5296,3932,6195,2889,5594,5579,4149,25780,27071,815,4690,3635,5601,4208,118788,4209,673,1386,867,4609,5605,3265,207,1385,5580,8462,5599,7462,8395,26469,6654,6850,974,2113,8394,5335,4792,2885,11184,930,1398,1147,6464,3725,1871,2534,1380,7410,2969,973,4790,5604,5336,933,3662,4773,84433,5781,5880,10892,23396,8915	PTPN6,IKBKB,HCLS1,FOXO1,SH3BP2,REL,PDPK1,CDC42,GAB2,GSK3B,ILF2,BLNK,GAB1,BCL6,RAC1,MAPK4,CD81,RAF1,MAP2K6,PIK3CG,LYN,BLK,RELA,PTPRC,NFATC3,PIK3R1,MAPK14,MAP3K7,VAV1,GSK3A,PIK3R2,LCK,RPS6KA1,RAPGEF1,MAPK1,PRKCB,MAX,RASGRP3,DAPP1,CAMK2A,NCK1,INPP5D,MAPK9,MEF2C,PIK3AP1,MEF2D,BRAF,ATF2,CBL,MYC,MAP2K2,HRAS,AKT1,CREB1,PRKCD,KLF11,MAPK8,LAT2,PIP5K1B,PTPN18,SOS1,SYK,CD79B,ETS1,PIP5K1A,PLCG1,NFKBIA,GRB2,MAP4K1,CD19,CRK,CHUK,SHC1,JUN,E2F3,FYN,CR2,VAV2,GTF2I,CD79A,NFKB1,MAP2K1,PLCG2,CD22,IRF4,NFATC2,CARD11,PTPN11,RAC2,MALT1,PIP5K1C,BCL10
WP1982	Sterol Regulatory Element-Binding Proteins (SREBP) signalling	0.0773171470772032	-2.55983952292746	73	69	0.014627941488234	4717	5310	5950,10802,2224,3638,9871,26291,53632,6667,207,1385,5564,6721,2475,3949,10483,5290,22937,3422,8720,1622,2194,22926,10484,2222,51141,3156,820,949,133522,25956,51128,5562,57678,3837,5566,5563,7528,23411,4023,3630,51586,407039,4190,10427,56681,267,9632,4800,1024,7376,1595,4597,31,6396,5565,11236,5571,23175,47,2931,5468,51422,6713,3157,22872,6319,693120,84532,6720	RBP4,SEC24A,FDPS,INSIG1,SEC24D,FGF21,PRKAG3,SP1,AKT1,CREB1,PRKAB1,SREBF2,MTOR,LDLR,SEC23B,PIK3CA,SCAP,IDI1,MBTPS1,DBI,FASN,ATF6,SEC23A,FDFT1,INSIG2,HMGCR,CAMP,SCARB1,PPARGC1B,SEC31B,SAR1B,PRKAA1,GPAM,KPNB1,PRKACA,PRKAA2,YY1,SIRT1,LPL,INS,MED15,MIR33A,MDH1,SEC24B,SAR1A,AMFR,SEC24C,NFYA,CDK8,NR1H2,CYP51A1,MVD,ACACA,SEC13,PRKAB2,RNF139,PRKAG1,LPIN1,ACLY,GSK3A,PPARG,PRKAG2,SQLE,HMGCS1,SEC31A,SCD,MIR33B,ACSS1,SREBF1
WP399	Wnt Signaling Pathway and Pluripotency	0.0818159229480002	-2.50328339725065	106	99	0.0209879160483358	4717	5310	26190,85409,5529,100302237,8321,5523,8325,5583,5588,333926,5578,5579,8312,5590,89780,595,7473,1387,4800,6885,6657,8326,80326,5328,1499,894,8322,324,5527,1855,4316,5518,5587,387,5519,896,1856,7477,8324,5460,2932,51176,7475,8061,7855,11211,81029,7471,7157,7481,51384,1500,29127,1857,5581,120892,5602,1487,5048,7476,4041,5521,6416,8323,3725,10023,2535,5584,5580,85407,54361,7472,3949,1454,7482,2033,4040,5516,960,6934,5524,5520,83439,8313,5601,27022,5582,1488,79923,5522,6932,4609,2103,7474,5467,7976,5515,7480,7484	FBXW2,NKD2,PPP2R5E,MIR1281,FZD1,PPP2R3A,FZD8,PRKCH,PRKCQ,PPM1J,PRKCA,PRKCB,AXIN1,PRKCZ,WNT3A,CCND1,WNT3,CREBBP,NFYA,MAP3K7,SOX2,FZD9,WNT10A,PLAU,CTNNB1,CCND2,FZD4,APC,PPP2R5C,DVL1,MMP7,PPP2R1A,PRKD1,RHOA,PPP2R1B,CCND3,DVL2,WNT7B,FZD7,POU5F1,GSK3B,LEF1,WNT6,FOSL1,FZD5,FZD10,WNT5B,WNT1,TP53,WNT11,WNT16,CTNND1,RACGAP1,DVL3,PRKCE,LRRK2,MAPK10,CTBP1,PAFAH1B1,WNT7A,LRP5,PPP2R2B,MAP2K4,FZD6,JUN,FRAT1,FZD2,PRKCI,PRKCD,NKD1,WNT4,WNT2,LDLR,CSNK1E,WNT2B,EP300,LRP6,PPP2CB,CD44,TCF7L2,PTPA,PPP2R2A,TCF7L1,AXIN2,MAPK9,FOXD3,PRKCG,CTBP2,NANOG,PPP2R2C,TCF7,MYC,ESRRB,WNT5A,PPARD,FZD3,PPP2CA,WNT10B,WNT9B
WP1602	Nicotine Activity on Dopaminergic Neurons	0.0827624442882463	-2.49178089188354	21	21	0.00445198219207123	4717	5310	5499,1136,108,1138,1137,8973,84152,6571,1814,7054,1644,1815,1141,2782,1813,51305,1020,3777,54331,5566,2770	PPP1CA,CHRNA3,ADCY2,CHRNA5,CHRNA4,CHRNA6,PPP1R1B,SLC18A2,DRD3,TH,DDC,DRD4,CHRNB2,GNB1,DRD2,KCNK9,CDK5,KCNK3,GNG2,PRKACA,GNAI1
WP2848	Differentiation Pathway	0.0835581065413899	-2.48221300241899	48	46	0.00975196099215603	4717	5310	2249,4907,8600,2246,1950,3815,3479,5154,3630,7471,2056,8200,10468,3569,3624,89780,7043,22943,7173,238,4838,1436,4254,7422,4909,2255,1270,2247,3562,9241,7472,7482,7477,2253,6469,3570,2323,652,1435,7018,3577,7474,3082,5155,7040,10637	FGF4,NT5E,TNFSF11,FGF1,EGF,KIT,IGF1,PDGFA,INS,WNT1,EPO,GDF5,FST,IL6,INHBA,WNT3A,TGFB3,DKK1,TPO,ALK,NODAL,CSF1R,KITLG,VEGFA,NTF4,FGF10,CNTF,FGF2,IL3,NOG,WNT2,WNT2B,WNT7B,FGF8,SHH,IL6R,FLT3LG,BMP4,CSF1,TF,CXCR1,WNT5A,HGF,PDGFB,TGFB1,LEFTY1
WP299	Nuclear Receptors in Lipid Metabolism and Toxicity	0.0848809282468248	-2.46650584874628	35	34	0.00720797116811533	4717	5310	5914,1582,64240,1581,8856,693120,5825,9971,5916,8714,1591,5467,1559,5468,1592,9619,1244,7421,8647,1544,10062,5244,19,1580,1579,5465,9970,1594,1576,5915,1555,225,407039,5243	RARA,CYP8B1,ABCG5,CYP7A1,NR1I2,MIR33B,ABCD3,NR1H4,RARG,ABCC3,CYP24A1,PPARD,CYP2C9,PPARG,CYP26A1,ABCG1,ABCC2,VDR,ABCB11,CYP1A2,NR1H3,ABCB4,ABCA1,CYP4B1,CYP4A11,PPARA,NR1I3,CYP27B1,CYP3A4,RARB,CYP2B6,ABCD2,MIR33A,ABCB1
WP1422	Sphingolipid Metabolism	0.0932112689556745	-2.37288665305823	20	20	0.00423998304006784	4717	5310	29956,9514,91012,8611,10558,64781,57515,2531,166929,204219,253782,9517,79603,56624,427,55304,9331,8877,56848,130367	CERS2,GAL3ST1,CERS5,PLPP1,SPTLC1,CERK,SERINC1,KDSR,SGMS2,CERS3,CERS6,SPTLC2,CERS4,ASAH2,ASAH1,SPTLC3,B4GALT6,SPHK1,SPHK2,SGPP2
WP516	Hypertrophy Model	0.0932112689556745	-2.37288665305823	20	20	0.00423998304006784	4717	5310	11072,3606,1978,1977,27063,467,2660,3727,102,8013,3552,7422,1839,6935,3554,9948,4656,3458,3491,3475	DUSP14,IL18,EIF4EBP1,EIF4E,ANKRD1,ATF3,MSTN,JUND,ADAM10,NR4A3,IL1A,VEGFA,HBEGF,ZEB1,IL1R1,WDR1,MYOG,IFNG,CCN1,IFRD1
WP428	Wnt Signaling Pathway	0.0953993748849383	-2.34968325311814	70	66	0.0139919440322239	4717	5310	5527,1855,54361,5879,2535,894,5584,5580,324,387,896,7472,1454,3949,5587,7482,4040,7477,5582,8324,5601,6259,1856,7474,7480,7976,2932,4609,7855,8321,26190,7475,8061,5529,7471,5590,8312,5579,7481,51384,5583,8325,4920,4919,5588,11211,81029,5578,595,7473,5602,5048,7476,1857,5581,89780,8323,8326,3725,1499,10023,5328,80326,83999,4041,6424	PPP2R5C,DVL1,WNT4,RAC1,FZD2,CCND2,PRKCI,PRKCD,APC,RHOA,CCND3,WNT2,CSNK1E,LDLR,PRKD1,WNT2B,LRP6,WNT7B,PRKCG,FZD7,MAPK9,RYK,DVL2,WNT5A,WNT10B,FZD3,GSK3B,MYC,FZD5,FZD1,FBXW2,WNT6,FOSL1,PPP2R5E,WNT1,PRKCZ,AXIN1,PRKCB,WNT11,WNT16,PRKCH,FZD8,ROR2,ROR1,PRKCQ,FZD10,WNT5B,PRKCA,CCND1,WNT3,MAPK10,PAFAH1B1,WNT7A,DVL3,PRKCE,WNT3A,FZD6,FZD9,JUN,CTNNB1,FRAT1,PLAU,WNT10A,KREMEN1,LRP5,SFRP4
WP702	Metapathway biotransformation	0.0965901366613754	-2.33727864793144	177	163	0.0345558617765529	4717	5310	126410,55501,54658,2052,2326,9957,1565,166012,1109,113189,1581,2947,1557,1585,57404,1545,54490,54578,6783,79829,51126,7172,54575,2937,1312,285440,27233,6819,442038,266722,1586,3340,9420,1576,1572,2949,100526831,23563,1645,1582,9953,2948,119391,1553,1558,7363,10327,1562,199974,339983,100616414,10858,1559,6718,1593,54577,92292,8529,1646,4166,1580,1584,2330,1544,4837,2954,9348,9486,64377,2950,64579,9446,120227,54657,339761,9435,6817,221357,9394,8534,2328,27284,7364,10249,29785,54905,2329,80218,7881,2940,6822,1592,113612,2944,391365,2953,9027,10720,219970,57016,122830,54579,1549,1589,1594,10,6820,9196,54659,1573,4257,2877,1588,11283,1543,1583,2327,66002,10941,10164,57834,574537,260293,79807,2946,1595,9956,6799,51302,50515,1591,79799,9514,55226,79690,26151,56603,54600,9955,570,9469,64711,8514,89792,64816,83539,2936,231,2879,3176,22977,8644,4259,373156,1555,9653,1577,25830,4258,9951,2878,2053,2941	CYP4F22,CHST12,UGT1A1,EPHX1,FMO1,HS3ST1,CYP2D6,CHST13,AKR1C4,CHST14,CYP7A1,GSTM3,CYP2C19,CYP11B2,CYP20A1,CYP1B1,UGT2B28,UGT1A6,SULT1E1,NAA40,NAA20,TPMT,UGT1A10,GSS,COMT,CYP4V2,SULT1C4,SULT1C2,SULT1C3,HS6ST3,CYP17A1,NDST1,CYP7B1,CYP3A4,CYP2F1,GSTM5,SLX1B-SULT1A4,CHST5,AKR1C1,CYP8B1,HS3ST3B1,GSTM4,GSTO2,CYP2A13,CYP2C8,UGT2B4,AKR1A1,CYP2C18,CYP4Z1,NAT8L,MIR4761,CYP46A1,CYP2C9,AKR1D1,CYP27A1,UGT1A7,GLYATL1,CYP4F2,AKR1C2,CHST6,CYP4B1,CYP11B1,FMO5,CYP1A2,NNMT,GSTZ1,NDST3,CHST10,CHST8,GSTP1,NDST4,GSTO1,CYP2R1,UGT1A4,CYP27C1,CHST2,SULT1A1,GSTA5,HS6ST1,CHST1,FMO3,SULT1B1,UGT2B7,GLYAT,CYP2S1,CYP2W1,FMO4,NAA50,KCNAB1,GSTA3,SULT2A1,CYP26A1,CYP2U1,GSTM1,SULT6B1,GSTT2,NAT8,UGT2B11,GLYATL2,AKR1B10,NAA30,UGT1A5,CYP2A7,CYP21A2,CYP27B1,NAT2,SULT2B1,KCNAB3,UGT1A3,CYP2J2,MGST1,GPX2,CYP19A1,CYP4F8,CYP1A1,CYP11A1,FMO2,CYP4F12,UGT2A1,CHST4,CYP4F11,UGT2A2,CYP4X1,GSTCD,GSTM2,CYP51A1,HS3ST2,SULT1A2,CYP39A1,CHST11,CYP24A1,UGT2A3,GAL3ST1,NAT10,GAL3ST4,NAT9,CYP26B1,UGT1A9,HS3ST3A1,BAAT,CHST3,HS3ST6,KCNAB2,GAL3ST3,CYP3A43,CHST9,GSR,AKR1B1,GPX4,HNMT,AKR7A3,AKR1C3,MGST3,GSTK1,CYP2B6,HS2ST1,CYP3A5,SULT4A1,MGST2,HS3ST4,GPX3,EPHX2,GSTA4
WP2377	Integrated Pancreatic Cancer Pathway	0.0988103054117309	-2.31455337388104	197	181	0.038371846512614	4717	5310	4690,355,5601,7132,301,6794,7040,2512,820,1385,5599,2260,823,4193,2033,672,375,5933,1956,7153,596,3978,1874,3562,10111,4485,7031,1398,1147,3725,5154,5604,2246,5321,25885,1676,10468,5595,2146,5906,5914,3925,6469,6714,4137,84618,6776,1026,5888,898,27306,4087,4661,51719,5894,351,5111,3727,5290,1958,890,5243,8772,1471,5273,2099,675,5743,1387,595,5308,4216,843,9232,1432,581,43,2064,840,23411,3554,3486,4089,641,7298,356,5578,1030,5594,5350,4830,5915,4331,1017,815,6256,4609,4217,1630,25,7124,207,6667,10848,3845,7422,4914,5598,1616,4838,3732,5610,5156,7159,2280,317,6654,3624,5163,3375,472,7046,1019,7486,8554,4792,2281,627,2885,1605,1027,4790,693199,3479,1950,836,7057,6608,3326,5371,3726,7157,10411,995,5893,5347,4091,6009,3172,11200,10637,2247,324,2958,5058,4908,5879,1677,5596,1647,841,6240,701,9821,2100,4361,7490,100506742,1499,27113,2931,5728,6772,1111,842,5563,7150,100302237,9052,4052,1869	NCK1,FAS,MAPK9,TNFRSF1A,ANXA1,STK11,TGFB1,FTL,CAMP,CREB1,MAPK8,FGFR1,CAPN1,MDM2,EP300,BRCA1,ARF1,RBL1,EGFR,TOP2A,BCL2,LIG1,E2F4,IL3,RAD50,MST1,TFF1,CRK,CHUK,JUN,PDGFA,MAP2K1,FGF1,PLA2G4A,POLR1A,DFFA,FST,MAPK3,EZH2,RAP1A,RARA,STMN1,SHH,SRC,MAPT,NT5C1A,STAT5A,CDKN1A,RAD51,CCNE1,HPGDS,SMAD2,MYT1,CAB39,RAF1,APP,PCNA,JUND,PIK3CA,EGR1,CCNA2,ABCB1,FADD,CST3,SERPINB10,ESR1,BRCA2,PTGS2,CREBBP,CCND1,PITX2,MAP3K4,CASP10,PTTG1,MAPK14,BAX,ACHE,ERBB2,CASP7,SIRT1,IL1R1,IGFBP3,SMAD4,BLM,TYMS,FASLG,PRKCA,CDKN2B,MAPK1,PLN,NME1,RARB,MNAT1,CDK2,CAMK2A,RXRA,MYC,MAP3K5,DCC,ABL1,TNF,AKT1,SP1,PPP1R13L,KRAS,VEGFA,NTRK1,MAPK7,DAXX,NODAL,CD82,EIF2AK2,PDGFRA,TP53BP2,FKBP1A,APAF1,SOS1,INHBA,PDK1,IAPP,ATM,TGFBR1,CDK4,WRN,PIAS1,NFKBIA,FKBP1B,BDNF,GRB2,DAG1,CDKN1B,NFKB1,MIR614,IGF1,EGF,CASP3,THBS1,SMO,HSP90AB1,PML,JUNB,TP53,RAPGEF3,CDC25C,RAD52,PLK1,SMAD6,RHEB,HNF4A,CHEK2,LEFTY1,FGF2,APC,GTF2A2,PAK1,NTF3,RAC1,DFFB,MAPK4,GADD45A,CASP8,RRM1,BUB1B,RB1CC1,ESR2,MRE11,WT1,CASP12,CTNNB1,BBC3,GSK3A,PTEN,STAT1,CHEK1,CASP9,PRKAA2,TOP1,MIR1281,GPRC5A,LTBP1,E2F1
WP58	Monoamine GPCRs	0.102677652278791	-2.27616078768556	33	32	0.00678397286410854	4717	5310	3350,152,1812,3354,150,1131,3356,3269,3361,1815,1129,3274,3357,1132,1128,151,3362,154,1133,3351,3363,148,147,3352,1814,155,3360,146,1816,3355,1813,153	HTR1A,ADRA2C,DRD1,HTR1E,ADRA2A,CHRM3,HTR2A,HRH1,HTR5A,DRD4,CHRM2,HRH2,HTR2B,CHRM4,CHRM1,ADRA2B,HTR6,ADRB2,CHRM5,HTR1B,HTR7,ADRA1A,ADRA1B,HTR1D,DRD3,ADRB3,HTR4,ADRA1D,DRD5,HTR1F,DRD2,ADRB1
WP2197	Endothelin Pathways	0.102677652278791	-2.27616078768556	33	32	0.00678397286410854	4717	5310	5894,5739,153,4638,5604,1889,148,10203,488,5594,790,801,796,5578,23236,2769,2770,1910,4886,4846,1906,284485,55811,1909,2778,51764,4852,2974,805,10681,4632,10267	RAF1,PTGIR,ADRB1,MYLK,MAP2K1,ECE1,ADRA1A,CALCRL,ATP2A2,MAPK1,CAD,CALM1,CALCA,PRKCA,PLCB1,GNA15,GNAI1,EDNRB,NPY1R,NOS3,EDN1,RIIAD1,ADCY10,EDNRA,GNAS,GNG13,NPY,GUCY1B2,CALM2,GNB5,MYL1,RAMP1
WP69	T-Cell antigen Receptor (TCR)  Signaling Pathway	0.10407217517468	-2.26267062847767	91	85	0.0180199279202883	4717	5310	4792,2625,5295,3552,3569,3604,5335,916,3972,5970,6654,3578,917,2534,3725,7431,7189,3937,6464,1147,7409,1398,940,6885,2885,11184,1432,28988,4773,3662,10451,5604,10019,9308,4790,5296,5594,8915,3708,2353,10892,7535,5781,5588,84433,2533,5170,5966,1386,27040,919,3551,5601,4690,355,5595,1234,3702,5605,8767,9402,1326,7040,868,4772,9846,998,867,5894,2185,920,29851,3601,9051,5599,5058,5580,207,1385,3265,4988,915,3553,9020,3605	NFKBIA,GATA3,PIK3R1,IL1A,IL6,TNFRSF9,PLCG1,CD3E,LHB,RELA,SOS1,IL9,CD3G,FYN,JUN,VIM,TRAF6,LCP2,SHC1,CHUK,VAV1,CRK,CD28,MAP3K7,GRB2,MAP4K1,MAPK14,DBNL,NFATC2,IRF4,VAV3,MAP2K1,SH2B3,CD83,NFKB1,PIK3R2,MAPK1,BCL10,ITPR1,FOS,MALT1,ZAP70,PTPN11,PRKCQ,CARD11,FYB1,PDPK1,REL,ATF2,LAT,CD247,IKBKB,MAPK9,NCK1,FAS,MAPK3,CCR5,ITK,MAP2K2,RIPK2,GRAP2,MAP3K8,TGFB1,CBLB,NFATC1,GAB2,CDC42,CBL,RAF1,PTK2B,CD4,ICOS,IL15RA,PSTPIP1,MAPK8,PAK1,PRKCD,AKT1,CREB1,HRAS,OPRM1,CD3D,IL1B,MAP3K14,IL17A
WP3287	Overview of nanoparticle effects	0.104976761183758	-2.2540162753794	19	19	0.00402798388806445	4717	5310	3681,896,3576,596,5742,7124,2335,10000,581,3162,4798,1282,1401,3569,1001,5747,5293,3909,5743	ITGAD,CCND3,CXCL8,BCL2,PTGS1,TNF,FN1,AKT3,BAX,HMOX1,NFRKB,COL4A1,CRP,IL6,CDH3,PTK2,PIK3CD,LAMA3,PTGS2
WP3680	Association Between Physico-Chemical Features and Toxicity Associated Pathways	0.109409967584893	-2.21265328176537	68	64	0.0135679457282171	4717	5310	6654,5335,8536,6464,10096,4632,2885,8323,6416,345456,9475,2064,1499,1027,4741,3725,8326,5604,7855,8321,7039,4842,8325,2890,11211,8312,5216,51384,7481,5594,2876,5747,4690,8324,6714,2066,4609,2932,58,2335,10097,867,5515,7976,6776,1026,8322,5058,23002,2535,5599,207,324,1855,5894,4747,4638,5294,1956,375189,387,6647,4744,5217	SOS1,PLCG1,CAMK1,SHC1,ACTR3,MYL1,GRB2,FZD6,MAP2K4,PFN3,ROCK2,ERBB2,CTNNB1,CDKN1B,NEFM,JUN,FZD9,MAP2K1,FZD5,FZD1,TGFA,NOS1,FZD8,GRIA1,FZD10,AXIN1,PFN1,WNT16,WNT11,MAPK1,GPX1,PTK2,NCK1,FZD7,SRC,ERBB4,MYC,GSK3B,ACTA1,FN1,ACTR2,CBL,PPP2CA,FZD3,STAT5A,CDKN1A,FZD4,PAK1,DAAM1,FZD2,MAPK8,AKT1,APC,DVL1,RAF1,NEFL,MYLK,PIK3CG,EGFR,PFN4,RHOA,SOD1,NEFH,PFN2
WP138	Androgen receptor signaling pathway	0.110506044276227	-2.20268506018792	90	84	0.0178079287682849	4717	5310	387,388,2274,5901,1956,11143,57178,2033,672,4193,811,9612,5879,7337,1616,898,5925,207,1385,6667,5883,8648,8850,6049,1026,64800,2932,10524,998,3985,90427,6714,23598,2308,56924,5747,23028,860,11034,10498,7050,7341,7041,354,10399,100302237,10273,4089,23411,9063,9611,4088,2288,5296,7329,5052,9475,5728,8031,1499,3725,25942,8431,8202,9604,8611,6047,3065,573,6013,10499,5295,8554,595,6774,1387,2119,24149,51588,5970,166,6605,857,11315	RHOA,RHOB,FHL2,RAN,EGFR,KAT7,ZMIZ1,EP300,BRCA1,MDM2,CALR,NCOR2,RAC1,UBE3A,DAXX,CCNE1,RB1,AKT1,CREB1,SP1,RAD9A,NCOA1,KAT2B,RNF6,CDKN1A,EFCAB6,GSK3B,KAT5,CDC42,LIMK2,BMF,SRC,PATZ1,FOXO1,PAK6,PTK2,KDM1A,RUNX2,DSTN,CARM1,TGIF1,SUMO1,TGFB1I1,KLK3,RACK1,MIR1281,STUB1,SMAD4,SIRT1,PIAS2,NCOR1,SMAD3,FKBP4,PIK3R2,UBE2I,PRDX1,ROCK2,PTEN,NCOA4,CTNNB1,JUN,SIN3A,NR0B2,NCOA3,RNF14,PLPP1,RNF4,HDAC1,BAG1,RLN1,NCOA2,PIK3R1,PIAS1,CCND1,STAT3,CREBBP,ETV5,ZNF318,PIAS4,RELA,TLE5,SMARCE1,CAV1,PARK7
WP2884	NRF2 pathway	0.110867392202244	-2.19942045669536	143	132	0.0279838880644477	4717	5310	1579,3084,54659,1958,6526,221223,1548,6531,2877,4780,177,6514,64116,221074,23657,56606,2953,22949,66035,1728,3162,3082,2944,1066,2940,7364,91227,3337,340024,55117,2729,114112,6536,8884,6532,4259,2878,115584,131,2941,9152,125206,2678,4258,6540,144195,154091,7039,8824,2936,2042,60482,200010,92086,8714,55334,6534,54600,6530,1839,6515,7048,2946,6523,6528,10057,348932,159963,218,10257,54716,6529,7042,5226,388662,91252,8878,3320,1244,4199,25800,201266,11182,6517,7040,2512,9817,23764,5467,5155,54578,81031,54658,6538,5265,6533,2947,6256,23516,2950,283848,874,6527,3326,6649,221357,54657,4097,29988,54577,2939,6513,2495,160728,6518,2938,7296,2730,873,29985,5052,29986,23491,7295,9588,2949,283375,114134,155184,2948,1969,57181	CYP4A11,NRG1,UGT1A3,EGR1,SLC5A3,CES5A,CYP2A6,SLC6A3,GPX2,NFE2L2,AGER,SLC2A2,SLC39A8,SLC39A12,SLC7A11,SLC2A9,GSTT2,PTGR1,SLC2A11,NQO1,HMOX1,HGF,GSTM1,CES1,GSTA3,UGT2B7,GGTLC2,DNAJB1,SLC6A19,SLC6A15,GCLC,TXNRD3,SLC6A9,SLC5A6,SLC6A4,MGST3,GPX3,SLC5A11,ADH7,GSTA4,SLC6A5,SLC5A10,GGT1,MGST2,SLC6A13,SLC2A14,SLC2A12,TGFA,CES2,GSR,EPHA3,SLC5A7,SLC5A9,GGTLC1,ABCC3,SLC39A9,SLC6A7,UGT1A9,SLC6A2,HBEGF,SLC2A3,TGFBR2,GSTM2,SLC5A1,SLC5A5,ABCC5,SLC6A18,SLC5A12,ALDH3A1,ABCC4,SLC6A20,SLC6A1,TGFB2,PGD,SLC6A17,SLC39A13,SQSTM1,HSP90AA1,ABCC2,ME1,SLC39A6,SLC39A11,SLC2A6,SLC2A4,TGFB1,FTL,KEAP1,MAFF,PPARD,PDGFB,UGT1A6,SLC2A10,UGT1A1,SLC6A11,SERPINA1,SLC6A6,GSTM3,RXRA,SLC39A14,GSTP1,CES4A,CBR3,SLC5A4,HSP90AB1,SOD3,GSTA5,UGT1A4,MAFG,SLC2A8,UGT1A7,GSTA2,SLC2A1,FTH1,SLC5A8,SLC2A5,GSTA1,TXNRD1,GCLM,CBR1,SLC39A3,PRDX1,SLC39A2,CES3,TXN,PRDX6,GSTM5,SLC39A5,SLC2A13,SLC2A7,GSTM4,EPHA2,SLC39A10
WP2875	Constitutive Androstane Receptor Pathway	0.112826498006853	-2.18190405609727	32	31	0.00657197371210515	4717	5310	10499,6256,2308,54658,10891,54600,1559,6822,54578,8714,1557,7266,23054,6667,8648,2939,3320,1244,1576,5524,1548,1962,5243,6817,1555,54657,1577,9970,54659,1579,211	NCOA2,RXRA,FOXO1,UGT1A1,PPARGC1A,UGT1A9,CYP2C9,SULT2A1,UGT1A6,ABCC3,CYP2C19,DNAJC7,NCOA6,SP1,NCOA1,GSTA2,HSP90AA1,ABCC2,CYP3A4,PTPA,CYP2A6,EHHADH,ABCB1,SULT1A1,CYP2B6,UGT1A4,CYP3A5,NR1I3,UGT1A3,CYP4A11,ALAS1
WP2828	Bladder Cancer	0.112826498006853	-2.18190405609727	32	31	0.00657197371210515	4717	5310	9252,2064,5605,1026,3576,11186,1029,1612,4312,23604,4609,1019,5295,2261,999,693222,595,673,1869,7157,5594,1956,7057,4193,1613,7422,5604,5925,1950,3265,5296	RPS6KA5,ERBB2,MAP2K2,CDKN1A,CXCL8,RASSF1,CDKN2A,DAPK1,MMP1,DAPK2,MYC,CDK4,PIK3R1,FGFR3,CDH1,MIR637,CCND1,BRAF,E2F1,TP53,MAPK1,EGFR,THBS1,MDM2,DAPK3,VEGFA,MAP2K1,RB1,EGF,HRAS,PIK3R2
WP2332	Interleukin-11 Signaling Pathway	0.116259588556567	-2.15192975570911	44	42	0.00890396438414246	4717	5310	5595,332,860,5970,3551,6194,6774,3673,5170,6714,8554,7525,5295,3590,2885,9021,7040,1147,6198,2242,5605,2534,3381,6772,5296,3265,1385,207,466,3572,5604,3717,3716,7297,3383,5894,6195,632,5781,5594,5524,596	MAPK3,BIRC5,RUNX2,RELA,IKBKB,RPS6,STAT3,ITGA2,PDPK1,SRC,PIAS1,YES1,PIK3R1,IL11RA,GRB2,SOCS3,TGFB1,CHUK,RPS6KB1,FES,MAP2K2,FYN,IBSP,STAT1,PIK3R2,HRAS,CREB1,AKT1,ATF1,IL6ST,MAP2K1,JAK2,JAK1,TYK2,ICAM1,RAF1,RPS6KA1,BGLAP,PTPN11,MAPK1,PTPA,BCL2
WP314	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation	0.116259588556567	-2.15192975570911	44	42	0.00890396438414246	4717	5310	8772,596,4799,7867,841,356,5062,839,1676,836,1616,11124,842,1677,5599,5925,142,9261,60,5058,4000,71,840,6416,7124,8767,5591,3725,58,6885,843,84823,3552,397,54205,4214,4001,3315,8837,6709,355,317	FADD,BCL2,NFX1,MAPKAPK3,CASP8,FASLG,PAK2,CASP6,DFFA,CASP3,DAXX,FAF1,CASP9,DFFB,MAPK8,RB1,PARP1,MAPKAPK2,ACTB,PAK1,LMNA,ACTG1,CASP7,MAP2K4,TNF,RIPK2,PRKDC,JUN,ACTA1,MAP3K7,CASP10,LMNB2,IL1A,ARHGDIB,CYCS,MAP3K1,LMNB1,HSPB1,CFLAR,SPTAN1,FAS,APAF1
WP585	Interferon type I signaling pathways	0.122629091309762	-2.09859099725146	55	52	0.0110239559041764	4717	5310	5296,6772,3932,5293,8660,10399,1975,5781,2889,7535,27250,8651,5788,64223,79109,6774,5295,8554,1432,9021,3454,1398,7409,3667,100616113,6198,1978,2534,1385,10379,5879,3455,7297,3716,6775,5606,2475,5608,5777,5906,4214,6194,5966,867,9846,3276,8986,6773,1977,57521,9252,6776	PIK3R2,STAT1,LCK,PIK3CD,IRS2,RACK1,EIF4B,PTPN11,RAPGEF1,ZAP70,PDCD4,SOCS1,PTPRC,MLST8,MAPKAP1,STAT3,PIK3R1,PIAS1,MAPK14,SOCS3,IFNAR1,CRK,VAV1,IRS1,MIR4680,RPS6KB1,EIF4EBP1,FYN,CREB1,IRF9,RAC1,IFNAR2,TYK2,JAK1,STAT4,MAP2K3,MTOR,MAP2K6,PTPN6,RAP1A,MAP3K1,RPS6,REL,CBL,GAB2,PRMT1,RPS6KA4,STAT2,EIF4E,RPTOR,RPS6KA5,STAT5A
WP2324	AGE/RAGE pathway	0.125154214970168	-2.07820858232536	66	62	0.0131439474242103	4717	5310	998,1729,6776,5595,3551,5601,653361,3091,3643,4846,2308,6714,4322,1386,841,1956,114609,3625,6647,177,387,7430,6667,5580,207,4087,5599,4316,5879,5894,4313,4318,1432,3958,6464,1650,1147,3667,3725,51135,6777,4481,5970,6774,54205,4792,249,5578,4323,5594,3630,5590,5579,4615,6772,4790,4088,5604,842,5321,3717,836	CDC42,DIAPH1,STAT5A,MAPK3,IKBKB,MAPK9,NCF1,HIF1A,INSR,NOS3,FOXO1,SRC,MMP13,ATF2,CASP8,EGFR,TIRAP,INHBB,SOD1,AGER,RHOA,EZR,SP1,PRKCD,AKT1,SMAD2,MAPK8,MMP7,RAC1,RAF1,MMP2,MMP9,MAPK14,LGALS3,SHC1,DDOST,CHUK,IRS1,JUN,IRAK4,STAT5B,MSR1,RELA,STAT3,CYCS,NFKBIA,ALPL,PRKCA,MMP14,MAPK1,INS,PRKCZ,PRKCB,MYD88,STAT1,NFKB1,SMAD3,MAP2K1,CASP9,PLA2G4A,JAK2,CASP3
WP673	ErbB Signaling Pathway	0.131815823238026	-2.02634960920301	54	51	0.010811956752173	4717	5310	3084,145957,2475,1956,9542,5609,3845,2065,5599,685,2549,3265,4193,4609,2932,10000,6776,1026,25,5747,815,4690,2069,6714,2308,2066,5578,7157,23624,5594,5604,1950,10298,7039,1398,10018,2885,374,2064,1027,1978,6198,3725,1839,23533,10718,25759,6654,5163,595,5335	NRG1,NRG4,MTOR,EGFR,NRG2,MAP2K7,KRAS,ERBB3,MAPK8,BTC,GAB1,HRAS,MDM2,MYC,GSK3B,AKT3,STAT5A,CDKN1A,ABL1,PTK2,CAMK2A,NCK1,EREG,SRC,FOXO1,ERBB4,PRKCA,TP53,CBLC,MAPK1,MAP2K1,EGF,PAK4,TGFA,CRK,BCL2L11,GRB2,AREG,ERBB2,CDKN1B,EIF4EBP1,RPS6KB1,JUN,HBEGF,PIK3R5,NRG3,SHC2,SOS1,PDK1,CCND1,PLCG1
WP15	Selenium Micronutrient Network	0.131834500083717	-2.02620793028916	87	81	0.0171719313122748	4717	5310	1733,348303,247,1401,3553,335,3949,22928,6647,240,5742,2877,8564,58515,4791,1735,4353,140606,3458,55163,91227,3643,114112,6414,280636,5340,7498,4524,213,7124,55312,875,5327,10935,949,257202,3043,1491,7001,10587,9403,6288,4790,3383,241,51714,6289,8942,7296,2936,19,5054,847,6649,83642,6415,2879,3630,6648,1734,2878,2678,2876,5743,12,2147,7295,5970,2155,80308,55829,3569,3039,92086,25824,51734,57190,5052,338,6347,4548	DIO1,SELENOV,ALOX15B,CRP,IL1B,APOA1,LDLR,SEPHS2,SOD1,ALOX5,PTGS1,GPX2,KMO,SELENOK,NFKB2,DIO3,MPO,SELENOM,IFNG,PNPO,GGTLC2,INSR,TXNRD3,SELENOP,SELENOH,PLG,XDH,MTHFR,ALB,TNF,RFK,CBS,PLAT,PRDX3,SCARB1,GPX6,HBB,CTH,PRDX2,TXNRD2,SELENOF,SAA1,NFKB1,ICAM1,ALOX5AP,SELENOT,SAA2,KYNU,TXNRD1,GSR,ABCA1,SERPINE1,CAT,SOD3,SELENOO,SELENOW,GPX4,INS,SOD2,DIO2,GPX3,GGT1,GPX1,PTGS2,SERPINA3,F2,TXN,RELA,F7,FLAD1,SELENOS,IL6,HBA1,GGTLC1,PRDX5,MSRB1,SELENON,PRDX1,APOB,CCL2,MTR
WP2289	Drug Induction of Bile Acid Pathway	0.13314093301329	-2.01634706507321	17	17	0.00360398558405766	4717	5310	200931,5243,6822,10257,123264,1576,9971,6554,8714,9970,8856,1581,1244,7421,570,10599,8647	SLC51A,ABCB1,SULT2A1,ABCC4,SLC51B,CYP3A4,NR1H4,SLC10A1,ABCC3,NR1I3,NR1I2,CYP7A1,ABCC2,VDR,BAAT,SLCO1B1,ABCB11
WP3874	Canonical and Non-Canonical TGF-B signaling	0.13314093301329	-2.01634706507321	17	17	0.00360398558405766	4717	5310	657,1432,649,7040,26585,4089,84171,4015,7048,4016,4017,5601,7046,659,5599,4088,4087	BMPR1A,MAPK14,BMP1,TGFB1,GREM1,SMAD4,LOXL4,LOX,TGFBR2,LOXL1,LOXL2,MAPK9,TGFBR1,BMPR2,MAPK8,SMAD3,SMAD2
WP2037	Prolactin Signaling Pathway	0.133435517335987	-2.01413693404157	76	71	0.0150519397922408	4717	5310	5781,2353,7535,8651,4752,5594,140885,5618,5604,4790,6772,5296,836,8660,3717,3659,3667,7409,5291,6464,1432,9021,2885,2534,6196,7410,2064,6777,3725,1978,6198,5970,5478,6654,5295,4792,6774,5479,2475,4793,5294,5829,5290,116986,7532,5617,5058,5599,207,3265,1509,8835,5894,3716,5879,1154,4609,9846,5770,2932,867,6776,5605,5601,5747,5595,5777,7534,6714,3688,6194	PTPN11,FOS,ZAP70,SOCS1,NEK3,MAPK1,SIRPA,PRLR,MAP2K1,NFKB1,STAT1,PIK3R2,CASP3,IRS2,JAK2,IRF1,IRS1,VAV1,PIK3CB,SHC1,MAPK14,SOCS3,GRB2,FYN,RPS6KA2,VAV2,ERBB2,STAT5B,JUN,EIF4EBP1,RPS6KB1,RELA,PPIA,SOS1,PIK3R1,NFKBIA,STAT3,PPIB,MTOR,NFKBIB,PIK3CG,PXN,PIK3CA,AGAP2,YWHAG,PRL,PAK1,MAPK8,AKT1,HRAS,CTSD,SOCS2,RAF1,JAK1,RAC1,CISH,MYC,GAB2,PTPN1,GSK3B,CBL,STAT5A,MAP2K2,MAPK9,PTK2,MAPK3,PTPN6,YWHAZ,SRC,ITGB1,RPS6
WP129	Matrix Metalloproteinases	0.135962879346363	-1.99537337648525	30	29	0.00614797540809837	4717	5310	4327,64386,4323,6942,9313,4326,4314,10893,79148,8510,4324,4319,4320,4318,4317,4313,4316,4312,682,56547,4325,7124,118856,4321,7078,7077,64066,4322,7079	MMP19,MMP25,MMP14,TCF20,MMP20,MMP17,MMP3,MMP24,MMP28,MMP23B,MMP15,MMP10,MMP11,MMP9,MMP8,MMP2,MMP7,MMP1,BSG,MMP26,MMP16,TNF,MMP21,MMP12,TIMP3,TIMP2,MMP27,MMP13,TIMP4
WP98	Prostaglandin Synthesis and Regulation	0.135962879346363	-1.99537337648525	30	29	0.00614797540809837	4717	5310	302,1906,6916,1910,309,306,1909,5743,5732,3290,301,6281,5740,308,5729,5731,307,3248,5739,5321,7356,6277,5617,5737,5733,3291,5742,1583,5734	ANXA2,EDN1,TBXAS1,EDNRB,ANXA6,ANXA3,EDNRA,PTGS2,PTGER2,HSD11B1,ANXA1,S100A10,PTGIS,ANXA5,PTGDR,PTGER1,ANXA4,HPGD,PTGIR,PLA2G4A,SCGB1A1,S100A6,PRL,PTGFR,PTGER3,HSD11B2,PTGS1,CYP11A1,PTGER4
WP2036	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway	0.136556195261117	-1.99101906218229	42	40	0.00847996608013568	4717	5310	7124,1499,3725,6347,7188,1147,84676,7187,2932,3065,6885,1432,6352,4792,330,3569,3551,5970,5601,4791,5595,8772,329,7185,8742,5594,4793,9020,841,836,4318,5894,5879,208,5599,207,8737,4790,840,5971	TNF,CTNNB1,JUN,CCL2,TRAF5,CHUK,TRIM63,TRAF3,GSK3B,HDAC1,MAP3K7,MAPK14,CCL5,NFKBIA,BIRC3,IL6,IKBKB,RELA,MAPK9,NFKB2,MAPK3,FADD,BIRC2,TRAF1,TNFSF12,MAPK1,NFKBIB,MAP3K14,CASP8,CASP3,MMP9,RAF1,RAC1,AKT2,MAPK8,AKT1,RIPK1,NFKB1,CASP7,RELB
WP49	IL-2 Signaling Pathway	0.136556195261117	-1.99101906218229	42	40	0.00847996608013568	4717	5310	3560,867,4137,2885,9021,9846,4609,6464,6199,6777,6198,3725,9111,2534,6776,5605,6654,5595,6850,2309,6774,6194,5295,3558,5781,2353,3559,5594,596,3265,6772,3932,207,894,5604,3718,1154,3716,2185,5894	IL2RB,CBL,MAPT,GRB2,SOCS3,GAB2,MYC,SHC1,RPS6KB2,STAT5B,RPS6KB1,JUN,NMI,FYN,STAT5A,MAP2K2,SOS1,MAPK3,SYK,FOXO3,STAT3,RPS6,PIK3R1,IL2,PTPN11,FOS,IL2RA,MAPK1,BCL2,HRAS,STAT1,LCK,AKT1,CCND2,MAP2K1,JAK3,CISH,JAK1,PTK2B,RAF1
WP363	Wnt Signaling Pathway Netpath	0.141587183274075	-1.95483961542029	53	50	0.0105999576001696	4717	5310	2475,1454,8395,4040,7248,6934,7249,387,5599,607,207,324,1855,5879,1021,2932,6656,4609,51176,1452,55361,8313,5601,6259,1856,409,5582,4920,4919,5578,6925,5579,8312,5594,2646,1453,2697,4773,4041,7010,6885,5468,2931,6929,10023,1499,1857,595,1487,53944	MTOR,CSNK1E,PIP5K1B,LRP6,TSC1,TCF7L2,TSC2,RHOA,MAPK8,BCL9,AKT1,APC,DVL1,RAC1,CDK6,GSK3B,SOX1,MYC,LEF1,CSNK1A1,PI4K2A,AXIN2,MAPK9,RYK,DVL2,ARRB2,PRKCG,ROR2,ROR1,PRKCA,TCF4,PRKCB,AXIN1,MAPK1,GCKR,CSNK1D,GJA1,NFATC2,LRP5,TEK,MAP3K7,PPARG,GSK3A,TCF3,FRAT1,CTNNB1,DVL3,CCND1,CTBP1,CSNK1G1
WP3594	Circadian rythm related genes	0.148529488758163	-1.90697176295723	207	189	0.0400678397286411	4717	5310	3400,83759,51738,1392,3184,5971,7311,220202,5629,23596,4297,56938,1390,2837,55366,181,1406,2691,1960,2932,6500,8864,4862,5563,7150,100302237,9967,2673,8454,7054,3066,79365,10419,3363,1628,6532,54551,6096,406,6770,10891,6496,25942,5728,79723,6928,57805,8403,5593,4914,191,9099,468,405,1644,5500,3398,1454,1859,5582,2063,1815,8914,26224,1408,463,5187,4159,4783,121278,150094,8792,10743,114781,7157,1814,196,5371,687,9915,1019,10499,23291,1364,10514,94233,4543,5468,135,1812,85457,5501,1813,5551,128674,10911,9370,1141,9572,90134,134,1471,5936,1958,3727,3751,4544,7316,3062,551,2146,10135,9456,5591,8553,5499,8841,9575,10062,3778,7298,23411,9611,1453,6095,4987,8204,5465,3061,594857,3569,100616483,9956,4804,2767,23239,56339,6720,3065,55269,7337,3952,1385,1660,5599,100,8945,7153,129521,8863,3399,107,2033,6421,60675,9975,50865,23064,15,6097,1128,355,5601,4547,2776,5562,7080,6550,22871,4916,5054,22809,7071,112464,148523,23373,5927,4887,5602,7166,5078,2155,6233,1407,3725,1374,25819,9475,3192	ID4,RBM4B,GHRL,CRH,HNRNPD,RELB,UBA52,ATOH7,PROX1,OPN3,KMT2A,BMAL2,CREM,UTS2R,LGR4,AGRP,CRX,GHRH,EGR3,GSK3B,SKP1,PER2,NPAS2,PRKAA2,TOP1,MIR1281,THRAP3,GFPT1,CUL1,TH,HDAC2,BHLHE41,PRMT5,HTR7,DBP,SLC6A4,MAGEL2,RORB,BMAL1,STAR,PPARGC1A,SIX3,SIN3A,PTEN,SUV39H2,HNF1B,CCAR2,SOX14,PRKG2,NTRK1,AHCY,USP2,ATF4,ARNT,DDC,PPP1CB,ID2,CSNK1E,DYRK1A,PRKCG,NR2F6,DRD4,TIMELESS,FBXL3,CRY2,ZFHX3,PER1,MC3R,NFIL3,TPH2,SIK1,TNFRSF11A,RAI1,BTBD9,TP53,DRD3,AHR,PML,KLF9,ARNT2,CDK4,NCOA2,FBXW11,CLDN4,MYBBP1A,OPN4,MTNR1A,PPARG,ADORA2A,DRD1,CIPC,PPP1CC,DRD2,PRF1,PROKR2,UTS2,ADIPOQ,CHRNB2,NR1D1,KCNH7,ADORA1,CST3,RBM4,EGR1,JUND,KCND2,MTNR1B,UBC,HCRTR2,AVP,EZH2,NAMPT,HOMER1,PRKDC,BHLHE40,PPP1CA,HDAC3,CLOCK,NR1H3,KCNMA1,TYMS,SIRT1,NCOR1,CSNK1D,RORA,OPRL1,NRIP1,PPARA,HCRTR1,NPS,IL6,MIR4751,HS3ST2,NGFR,GNA11,PHLPP1,METTL3,SREBF1,HDAC1,PSPC1,UBE3A,LEP,CREB1,DHX9,MAPK8,ADA,BTRC,TOP2A,NMS,PER3,ID3,ADCY1,EP300,SFPQ,PROK2,NR1D2,HEBP1,SETX,AANAT,RORC,CHRM1,FAS,MAPK9,MTTP,GNAQ,PRKAA1,NKX2-1,SLC9A3,NLGN1,NTRK3,SERPINE1,ATF5,KLF10,CAVIN3,CIART,CRTC1,KDM5A,NPY2R,MAPK10,TPH1,PAX4,F7,RPS27A,CRY1,JUN,CPT1A,NOCT,ROCK2,HNRNPU
WP12	Osteoclast Signaling	0.149935779487877	-1.89754821331007	16	16	0.00339198643205427	4717	5310	3690,4982,3456,8792,5599,6696,8600,56302,7965,8111,6548,3454,54,5155,1513,9550	ITGB3,TNFRSF11B,IFNB1,TNFRSF11A,MAPK8,SPP1,TNFSF11,TRPV5,AIMP2,GPR68,SLC9A1,IFNAR1,ACP5,PDGFB,CTSK,ATP6V1G1
WP47	Hedgehog Signaling Pathway	0.149935779487877	-1.89754821331007	16	16	0.00339198643205427	4717	5310	27148,2736,25942,10284,2737,5727,374654,50846,3549,2735,156,6469,6608,406,8643,51684	STK36,GLI2,SIN3A,SAP18,GLI3,PTCH1,KIF7,DHH,IHH,GLI1,GRK2,SHH,SMO,BMAL1,PTCH2,SUFU
WP501	GPCRs, Class C Metabotropic glutamate, pheromone	0.149935779487877	-1.89754821331007	16	16	0.00339198643205427	4717	5310	55507,693199,2915,51704,2916,2917,2918,846,55890,9052,2913,2550,2912,9568,2911,2914	GPRC5D,MIR614,GRM5,GPRC5B,GRM6,GRM7,GRM8,CASR,GPRC5C,GPRC5A,GRM3,GABBR1,GRM2,GABBR2,GRM1,GRM4
WP24	Peptide GPCRs	0.150675227527923	-1.89262856955661	74	69	0.014627941488234	4717	5310	6754,2693,4923,5540,1232,23620,10663,6870,185,2357,4160,4988,719,2492,4986,7852,3973,1234,4889,728,1230,6752,4886,643,4888,886,1237,4985,7201,4159,8484,887,4829,255061,4158,3577,5021,10396,553,2826,10803,6869,2587,6753,2358,2532,1524,623,2359,4987,1235,1909,6751,2798,3061,1910,4887,6865,1233,3579,729230,1236,8811,624,6755,552,7253,4161,4157	SSTR4,GHSR,NTSR1,NPY4R,CCR3,NTSR2,CXCR6,TACR3,AGTR1,FPR1,MC4R,OPRM1,C3AR1,FSHR,OPRK1,CXCR4,LHCGR,CCR5,NPY5R,C5AR1,CCR1,SSTR2,NPY1R,CXCR5,NPY6R,CCKAR,CCR8,OPRD1,TRHR,MC3R,GALR3,CCKBR,NMBR,TAC4,MC2R,CXCR1,OXTR,ATP8A1,AVPR1B,CCR10,CCR9,TACR1,GALR1,SSTR3,FPR2,ACKR1,CX3CR1,BDKRB1,FPR3,OPRL1,CCR6,EDNRA,SSTR1,GNRHR,HCRTR1,EDNRB,NPY2R,TACR2,CCR4,CXCR2,CCR2,CCR7,GALR2,BDKRB2,SSTR5,AVPR1A,TSHR,MC5R,MC1R
WP3624	Lung fibrosis	0.152339522080178	-1.88164355123437	63	59	0.0125079499682001	4717	5310	4318,4313,1232,7015,51750,6696,2247,91039,4780,796,5806,3553,1832,4502,729238,6352,653509,5265,3567,3593,2006,2920,1490,79991,3596,3082,7124,1215,5155,6348,7040,10144,57105,3162,727897,3565,7039,1437,3479,2246,1950,255520,5154,23250,655,2252,6356,5073,1906,3569,6498,6351,4092,1051,5328,3576,6347,729230,26585	MMP9,MMP2,CCR3,TERT,RTEL1,SPP1,FGF2,DPP9,NFE2L2,CALCA,PTX3,IL1B,DSP,MT2A,SFTPA2,CCL5,SFTPA1,SERPINA1,IL5,IL12B,ELN,CXCL2,CCN2,STN1,IL13,HGF,TNF,CMA1,PDGFB,CCL3,TGFB1,FAM13A,CYSLTR2,HMOX1,MUC5B,IL4,TGFA,CSF2,IGF1,FGF1,EGF,ELMOD2,PDGFA,ATP11A,BMP7,FGF7,CCL11,PARN,EDN1,IL6,SKIL,CCL4,SMAD7,CEBPB,PLAU,CXCL8,CCL2,CCR2,GREM1
WP127	IL-5 Signaling Pathway	0.159900710512659	-1.8332022156708	40	38	0.0080559677761289	4717	5310	6774,161742,6194,5295,6850,5595,6654,2309,3568,6777,3725,6198,2931,6776,5605,4137,2885,4609,6199,2932,6464,3717,5894,3716,207,6772,5296,5604,3845,1439,5594,4067,596,6195,5781,3558,5294,2353	STAT3,SPRED1,RPS6,PIK3R1,SYK,MAPK3,SOS1,FOXO3,IL5RA,STAT5B,JUN,RPS6KB1,GSK3A,STAT5A,MAP2K2,MAPT,GRB2,MYC,RPS6KB2,GSK3B,SHC1,JAK2,RAF1,JAK1,AKT1,STAT1,PIK3R2,MAP2K1,KRAS,CSF2RB,MAPK1,LYN,BCL2,RPS6KA1,PTPN11,IL2,PIK3CG,FOS
WP306	Focal Adhesion	0.160771523544191	-1.82777103030685	195	178	0.0377358490566038	4717	5310	208,60,3909,7059,207,7791,7422,5753,5598,5156,4233,50509,5606,7294,7424,394,7060,673,3676,5881,2335,3479,5293,1950,7057,4637,5880,1286,1311,3913,3611,3918,6654,100500837,2885,3381,2534,7414,3371,53918,5058,5228,5596,5879,5608,10188,56034,8711,387,640,896,388,3480,56924,5747,3694,3690,63923,3673,5170,3688,3683,9564,2932,3082,859,8515,1729,3691,5296,2889,1278,7450,3695,2268,1290,3655,330,7148,7143,10319,5728,6300,7408,1499,1280,3675,5599,6696,1284,3265,3685,7058,1301,4638,823,3908,1956,2321,596,55359,3681,5908,5601,80310,6414,1282,29780,5605,85366,5155,5604,100616340,1302,5154,71,5597,3682,329,23396,858,1281,857,1398,3693,6464,1793,57144,3674,9475,3680,3684,3725,894,100422894,3910,10420,6725,5062,5894,5649,3914,8516,1277,5294,1101,5829,5290,53358,5159,3791,3689,3679,5906,3912,6714,10000,998,10298,4659,5607,30849,87,1289,22801,5594,23533,5295,595,3687,3911,7409,284217,5291,3915,3696,7423,2064	AKT2,ACTB,LAMA3,THBS3,AKT1,ZYX,VEGFA,PTK6,MAPK7,PDGFRA,MET,COL5A3,MAP2K3,TXK,VEGFC,ARHGAP5,THBS4,BRAF,ITGA4,RAC3,FN1,IGF1,PIK3CD,EGF,THBS1,MYL6,RAC2,COL4A4,COMP,LAMB2,ILK,LAMC2,SOS1,MIR3606,GRB2,IBSP,FYN,VCL,TNC,PELO,PAK1,PGF,MAPK4,RAC1,MAP2K6,TNK2,PDGFC,TNK1,RHOA,BLK,CCND3,RHOB,IGF1R,PAK6,PTK2,ITGB6,ITGB3,TNN,ITGA2,PDPK1,ITGB1,ITGAL,BCAR1,GSK3B,HGF,CAV3,ITGA10,DIAPH1,ITGB4,PIK3R2,RAPGEF1,COL1A2,VWF,ITGB7,FGR,COL5A2,ITGA6,BIRC3,TNXB,TNR,LAMC3,PTEN,MAPK12,VASP,CTNNB1,COL2A1,ITGA3,MAPK8,SPP1,COL4A2,HRAS,ITGAV,THBS2,COL11A1,MYLK,CAPN1,LAMA2,EGFR,FLT1,BCL2,STYK1,ITGAD,RAP1B,MAPK9,PDGFD,SELENOP,COL4A1,PARVB,MAP2K2,MYLK2,PDGFB,MAP2K1,MIR4758,COL11A2,PDGFA,ACTG1,MAPK6,ITGAE,BIRC2,PIP5K1C,CAV2,COL3A1,CAV1,CRK,ITGB5,SHC1,DOCK1,PAK5,ITGA2B,ROCK2,ITGA9,ITGAM,JUN,CCND2,MIR4260,LAMA4,TESK2,SRMS,PAK2,RAF1,RELN,LAMB3,ITGA8,COL1A1,PIK3CG,CHAD,PXN,PIK3CA,SHC3,PDGFRB,KDR,ITGB2,ITGA7,RAP1A,LAMB1,SRC,AKT3,CDC42,PAK4,PPP1R12A,MAP2K5,PIK3R4,ACTN1,COL5A1,ITGA11,MAPK1,PIK3R5,PIK3R1,CCND1,ITGAX,LAMA5,VAV1,LAMA1,PIK3CB,LAMC1,ITGB8,VEGFB,ERBB2
WP3863	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection	0.162424133330902	-1.81754425804076	62	58	0.0122959508161967	4717	5310	5335,4792,1019,5163,6654,11261,5788,3725,3937,2534,3586,6885,2885,1493,1147,940,1437,4773,3565,3932,4790,5604,8915,10892,7535,2353,5588,84433,27040,3458,4690,5595,6237,5777,3702,3567,3551,5601,9402,7124,5605,867,1326,805,10598,2932,29851,5894,920,1739,207,5058,801,5609,5290,915,9020,3558	PLCG1,NFKBIA,CDK4,PDK1,SOS1,CHP1,PTPRC,JUN,LCP2,FYN,IL10,MAP3K7,GRB2,CTLA4,CHUK,CD28,CSF2,NFATC2,IL4,LCK,NFKB1,MAP2K1,BCL10,MALT1,ZAP70,FOS,PRKCQ,CARD11,LAT,IFNG,NCK1,MAPK3,RRAS,PTPN6,ITK,IL5,IKBKB,MAPK9,GRAP2,TNF,MAP2K2,CBL,MAP3K8,CALM2,AHSA1,GSK3B,ICOS,RAF1,CD4,DLG1,AKT1,PAK1,CALM1,MAP2K7,PIK3CA,CD3D,MAP3K14,IL2
WP3	Transcriptional activation by NRF2	0.168845162140667	-1.77877318437822	15	15	0.00317998728005088	4717	5310	2729,2730,4094,7965,2939,23657,5599,4780,1051,2048,5578,9817,5290,1728,3162	GCLC,GCLM,MAF,AIMP2,GSTA2,SLC7A11,MAPK8,NFE2L2,CEBPB,EPHB2,PRKCA,KEAP1,PIK3CA,NQO1,HMOX1
WP2435	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis	0.168845162140667	-1.77877318437822	15	15	0.00317998728005088	4717	5310	7975,9817,2353,4312,4842,3725,4097,8309,4780,1548,4790,5743,3551,7422,4792	MAFK,KEAP1,FOS,MMP1,NOS1,JUN,MAFG,ACOX2,NFE2L2,CYP2A6,NFKB1,PTGS2,IKBKB,VEGFA,NFKBIA
WP383	Striated Muscle Contraction	0.186613996342584	-1.67871298618681	38	36	0.00763196947212211	4717	5310	4633,81,59,7171,4621,71,7125,7134,89,7111,8736,4703,7139,4634,1674,7136,7138,70,7273,4604,7168,4635,4624,7140,7169,7170,10398,4607,7431,8557,4606,7135,88,4632,4626,58	MYL2,ACTN4,ACTA2,TPM4,MYH3,ACTG1,TNNC2,TNNC1,ACTN3,TMOD1,MYOM1,NEB,TNNT2,MYL3,DES,TNNI2,TNNT1,ACTC1,TTN,MYBPC1,TPM1,MYL4,MYH6,TNNT3,TPM2,TPM3,MYL9,MYBPC3,VIM,TCAP,MYBPC2,TNNI1,ACTN2,MYL1,MYH8,ACTA1
WP2447	Amyotrophic lateral sclerosis (ALS)	0.186613996342584	-1.67871298618681	38	36	0.00763196947212211	4717	5310	317,5530,100506742,7132,581,4217,5533,10452,5630,1432,79139,5605,7124,4741,57679,598,9973,836,5532,5879,4747,1616,842,4842,847,5608,834,2890,5868,596,1471,6647,4744,6506,7157,2876	APAF1,PPP3CA,CASP12,TNFRSF1A,BAX,MAP3K5,PPP3CC,TOMM40,PRPH,MAPK14,DERL1,MAP2K2,TNF,NEFM,ALS2,BCL2L1,CCS,CASP3,PPP3CB,RAC1,NEFL,DAXX,CASP9,NOS1,CAT,MAP2K6,CASP1,GRIA1,RAB5A,BCL2,CST3,SOD1,NEFH,SLC1A2,TP53,GPX1
WP3925	Amino Acid metabolism	0.187712473502807	-1.67284388313413	91	84	0.0178079287682849	4717	5310	2752,586,8639,1743,1373,57818,6723,2746,1431,875,383,7407,11112,4191,6999,92935,6389,3939,5917,3034,5315,549,216,2937,1738,6898,7453,5091,790,1962,384,3067,1644,501,5831,445,3155,440,8802,7166,2744,127,4942,635,2805,5166,3033,8974,128,1621,34,84706,151742,126,47,5409,30,7173,84532,4594,4953,2184,2271,2730,2936,3376,3417,2806,26275,10993,4967,1491,5105,56922,5832,4190,131,50,7054,2058,23395,3176,8050,10056	GLUL,BCAT1,AOC3,DLST,CPS1,G6PC2,SRM,GLUD1,CS,CBS,ARG1,VARS1,HIBADH,MDH2,TDO2,MARS2,SDHA,LDHA,RARS1,HAL,PKM,AUH,ALDH1A1,GSS,DLD,TAT,WARS1,PC,CAD,EHHADH,ARG2,HDC,DDC,ALDH7A1,PYCR1,ASS1,HMGCL,ASNS,SUCLG1,TPH1,GLS,ADH4,OAT,BHMT,GOT1,PDK4,HADH,P4HA2,ADH5,DBH,ACADM,GPT2,PPM1L,ADH1C,ACLY,PNMT,ACAA1,TPO,ACSS1,MMUT,ODC1,FAH,FH,GCLM,GSR,IARS1,IDH1,GOT2,HIBCH,SDS,OGDH,CTH,PCK1,MCCC1,ALDH18A1,MDH1,ADH7,ACO2,TH,EPRS1,LARS2,HNMT,PDHX,FARSB
WP322	Osteoblast Signaling	0.190134803040717	-1.66002196870249	14	14	0.00296798812804749	4717	5310	5155,8074,3381,5159,5156,1277,5741,632,5745,3690,4982,3685,10246,8600	PDGFB,FGF23,IBSP,PDGFRB,PDGFRA,COL1A1,PTH,BGLAP,PTH1R,ITGB3,TNFRSF11B,ITGAV,SLC17A2,TNFSF11
WP229	Irinotecan Pathway	0.190134803040717	-1.66002196870249	14	14	0.00296798812804749	4717	5310	590,4363,1577,1066,1576,54600,54658,10599,324,4864,1244,9429,54575,8824	BCHE,ABCC1,CYP3A5,CES1,CYP3A4,UGT1A9,UGT1A1,SLCO1B1,APC,NPC1,ABCC2,ABCG2,UGT1A10,CES2
WP698	Glucuronidation	0.19568441086937	-1.63125206605974	26	25	0.0052999788000848	4717	5310	54657,3098,7365,54659,10720,54575,54579,55276,54577,54576,7358,5238,54490,54578,5236,54600,7366,79799,5239,7363,7360,10941,54658,574537,7364	UGT1A4,HK1,UGT2B10,UGT1A3,UGT2B11,UGT1A10,UGT1A5,PGM2,UGT1A7,UGT1A8,UGDH,PGM3,UGT2B28,UGT1A6,PGM1,UGT1A9,UGT2B15,UGT2A3,PGM5,UGT2B4,UGP2,UGT2A1,UGT1A1,UGT2A2,UGT2B7
WP382	MAPK Signaling Pathway	0.196216281928853	-1.62853774890847	170	155	0.0328598685605258	4717	5310	7157,10125,5535,834,5880,4763,2353,5597,836,5566,1846,4790,5604,1950,91,3725,6416,11184,2885,627,5536,2645,1398,3312,4296,5602,5494,57551,9175,120892,140738,7046,11221,7042,6655,468,5606,9020,9064,3553,1956,5495,4914,3316,1616,5598,2260,5532,8649,5322,207,5580,3845,208,23162,5599,10746,5155,4803,9252,6788,5605,7124,7850,7040,4609,1326,4217,673,1386,5582,409,355,5530,5801,3315,5534,5601,5908,4208,5594,5579,5590,4149,6722,9448,356,3309,5607,5922,5583,1848,1843,842,2249,929,840,1849,3554,115727,7189,5924,6300,100616122,4216,408,4893,1432,6885,5533,51776,3552,84867,7043,5778,22808,7048,5609,50488,5921,5159,3164,3727,841,5608,5603,5879,1847,8491,5596,10454,5062,1647,839,5894,9344,5058,4909,130399,9261,23118,835,10000,4137,998,994,4772,4342,3925,51295,2768,5595,5906,3551,4214	TP53,RASGRP1,PPP3R2,CASP1,RAC2,NF1,FOS,MAPK6,CASP3,PRKACA,DUSP4,NFKB1,MAP2K1,EGF,ACVR1B,JUN,MAP2K4,MAP4K1,GRB2,BDNF,PPP5C,GCK,CRK,HSPA8,MAP3K11,MAPK10,PPM1A,TAOK1,MAP3K13,LRRK2,TMEM37,TGFBR1,DUSP10,TGFB2,SOS2,ATF4,MAP2K3,MAP3K14,MAP3K6,IL1B,EGFR,PPM1B,NTRK1,HSPB2,DAXX,MAPK7,FGFR1,PPP3CB,LAMTOR3,PLA2G5,AKT1,PRKCD,KRAS,AKT2,MAPK8IP3,MAPK8,MAP3K2,PDGFB,NGF,RPS6KA5,STK3,MAP2K2,TNF,IL1R2,TGFB1,MYC,MAP3K8,MAP3K5,BRAF,ATF2,PRKCG,ARRB2,FAS,PPP3CA,PTPRR,HSPB1,PPP3R1,MAPK9,RAP1B,MEF2C,MAPK1,PRKCB,PRKCZ,MAX,SRF,MAP4K4,FASLG,HSPA5,MAP2K5,RASA2,PRKCH,DUSP6,DUSP1,CASP9,FGF4,CD14,CASP7,DUSP7,IL1R1,RASGRP4,TRAF6,RASGRF2,MAPK12,MIR4523,MAP3K4,ARRB1,NRAS,MAPK14,MAP3K7,PPP3CC,MAP3K20,IL1A,PTPN5,TGFB3,PTPN7,MRAS,TGFBR2,MAP2K7,MINK1,RASA1,PDGFRB,NR4A1,JUND,CASP8,MAP2K6,MAPK13,RAC1,DUSP5,MAP4K3,MAPK4,TAB1,PAK2,GADD45A,CASP6,RAF1,TAOK2,PAK1,NTF4,ACVR1C,MAPKAPK2,TAB2,CASP2,AKT3,MAPT,CDC42,CDC25B,NFATC1,MOS,STMN1,ECSIT,GNA12,MAPK3,RAP1A,IKBKB,MAP3K1
WP1471	Target Of Rapamycin (TOR) Signaling	0.201332683162914	-1.60279659904392	37	35	0.00741997032011872	4717	5310	5571,58528,5565,79109,64223,253260,10670,6009,3422,79899,5562,998,8408,115265,3156,1978,6198,51422,57521,55615,207,9706,84335,53632,5879,5563,64121,25989,7248,5578,54541,2475,2280,5564,7249	PRKAG1,RRAGD,PRKAB2,MAPKAP1,MLST8,RICTOR,RRAGA,RHEB,IDI1,PRR5L,PRKAA1,CDC42,ULK1,DDIT4L,HMGCR,EIF4EBP1,RPS6KB1,PRKAG2,RPTOR,PRR5,AKT1,ULK2,AKT1S1,PRKAG3,RAC1,PRKAA2,RRAGC,ULK3,TSC1,PRKCA,DDIT4,MTOR,FKBP1A,PRKAB1,TSC2
WP707	DNA Damage Response	0.201734777079275	-1.60080142905673	69	64	0.0135679457282171	4717	5310	1869,11011,7157,5893,995,5884,5371,842,1643,2810,836,891,1111,5366,1027,135458,55367,27113,27244,63970,581,54205,9133,1019,595,50484,1020,4616,317,2177,4361,472,6118,9874,896,10111,672,84126,993,841,8795,5810,1021,4193,1647,5888,1385,5883,894,898,5925,5981,25,545,5591,1026,9134,4609,10912,4683,11200,1017,355,983	E2F1,TLK2,TP53,RAD52,CDC25C,RAD17,PML,CASP9,DDB2,SFN,CASP3,CCNB1,CHEK1,PMAIP1,CDKN1B,HUS1B,PIDD1,BBC3,SESN1,TP53AIP1,BAX,CYCS,CCNB2,CDK4,CCND1,RRM2B,CDK5,GADD45B,APAF1,FANCD2,MRE11,ATM,RPA2,TLK1,CCND3,RAD50,BRCA1,ATRIP,CDC25A,CASP8,TNFRSF10B,RAD1,CDK6,MDM2,GADD45A,RAD51,CREB1,RAD9A,CCND2,CCNE1,RB1,RFC1,ABL1,ATR,PRKDC,CDKN1A,CCNE2,MYC,GADD45G,NBN,CHEK2,CDK2,FAS,CDK1
WP3679	Cell-type Dependent Selectivity of CCK2R Signaling	0.214103752485463	-1.54129455675138	13	13	0.0027559889760441	4717	5310	747,3708,885,7220,6263,2776,887,952,23236,1268,6261,2770,6262	DAGLA,ITPR1,CCK,TRPC1,RYR3,GNAQ,CCKBR,CD38,PLCB1,CNR1,RYR1,GNAI1,RYR2
WP3876	BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation	0.214103752485463	-1.54129455675138	13	13	0.0027559889760441	4717	5310	4093,1499,6422,1634,22943,7044,10018,54361,650,2308,4090,4086,6750	SMAD9,CTNNB1,SFRP1,DCN,DKK1,LEFTY2,BCL2L11,WNT4,BMP2,FOXO1,SMAD5,SMAD1,SST
WP2881	Estrogen Receptor Pathway	0.214103752485463	-1.54129455675138	13	13	0.0027559889760441	4717	5310	2099,6667,5105,5166,6774,51,1544,57678,5465,8431,1545,3725,1543	ESR1,SP1,PCK1,PDK4,STAT3,ACOX1,CYP1A2,GPAM,PPARA,NR0B2,CYP1B1,JUN,CYP1A1
WP1434	Osteopontin Signaling	0.214103752485463	-1.54129455675138	13	13	0.0027559889760441	4717	5310	3690,5595,4790,3685,3551,5604,5970,6696,4318,1147,9020,5328,5594	ITGB3,MAPK3,NFKB1,ITGAV,IKBKB,MAP2K1,RELA,SPP1,MMP9,CHUK,MAP3K14,PLAU,MAPK1
WP3892	Development of pulmonary dendritic cells and macrophage subsets	0.214103752485463	-1.54129455675138	13	13	0.0027559889760441	4717	5310	6774,1437,10320,3662,55509,1435,2323,3394,860,6925,6688,3398,7173	STAT3,CSF2,IKZF1,IRF4,BATF3,CSF1,FLT3LG,IRF8,RUNX2,TCF4,SPI1,ID2,TPO
WP2795	Cardiac Hypertrophic Response	0.221247669761734	-1.50847252729991	57	53	0.0112359550561798	4717	5310	6885,11184,5592,1432,1147,6416,7046,2978,5578,5607,5594,2263,4790,1022,1950,3479,5604,817,4773,805,2932,7040,9759,7124,5605,5530,5595,4214,9734,3551,4878,5320,5170,7132,5606,51564,5608,2475,3084,9020,5587,801,5609,207,2247,5599,10014,9641,208,5598,5879,5894,4205	MAP3K7,MAP4K1,PRKG1,MAPK14,CHUK,MAP2K4,TGFBR1,GUCA1A,PRKCA,MAP2K5,MAPK1,FGFR2,NFKB1,CDK7,EGF,IGF1,MAP2K1,CAMK2D,NFATC2,CALM2,GSK3B,TGFB1,HDAC4,TNF,MAP2K2,PPP3CA,MAPK3,MAP3K1,HDAC9,IKBKB,NPPA,PLA2G2A,PDPK1,TNFRSF1A,MAP2K3,HDAC7,MAP2K6,MTOR,NRG1,MAP3K14,PRKD1,CALM1,MAP2K7,AKT1,FGF2,MAPK8,HDAC5,IKBKE,AKT2,MAPK7,RAC1,RAF1,MEF2A
WP1971	Integrated Cancer Pathway	0.228419693808872	-1.47657057983482	46	43	0.00911596353614585	4717	5310	1869,7157,596,10111,672,571,993,841,1030,842,4193,836,3716,641,6772,466,207,4088,5925,2956,1111,4087,1027,545,5451,1026,5728,27113,994,581,4312,4609,4217,4436,1019,11200,100379661,1017,5347,4361,580,472,983	E2F1,TP53,BCL2,RAD50,BRCA1,BACH1,CDC25A,CASP8,CDKN2B,CASP9,MDM2,CASP3,JAK1,BLM,STAT1,ATF1,AKT1,SMAD3,RB1,MSH6,CHEK1,SMAD2,CDKN1B,ATR,POU2F1,CDKN1A,PTEN,BBC3,CDC25B,BAX,MMP1,MYC,MAP3K5,MSH2,CDK4,CHEK2,GRIK1-AS2,CDK2,PLK1,MRE11,BARD1,ATM,CDK1
WP2509	Nanoparticle triggered autophagic cell death	0.233550878508289	-1.45435533049843	24	23	0.00487598049607802	4717	5310	9706,83734,285973,9474,8678,55054,3643,81671,84557,406991,7248,7405,8408,22863,9140,64422,7249,10036,596,10533,3630,55626,51100	ULK2,ATG10,ATG9B,ATG5,BECN1,ATG16L1,INSR,VMP1,MAP1LC3A,MIR21,TSC1,UVRAG,ULK1,ATG14,ATG12,ATG3,TSC2,CHAF1A,BCL2,ATG7,INS,AMBRA1,SH3GLB1
WP3617	Photodynamic therapy-induced NF-kB survival signaling	0.233681169982102	-1.45379761414481	35	33	0.00699597201611194	4717	5310	4312,1147,7189,3576,7124,2920,332,4791,5743,5970,8837,3551,3569,330,595,3552,7132,5966,7412,3553,3558,6401,329,4314,5971,4790,597,112398,1437,7422,4313,3383,4318	MMP1,CHUK,TRAF6,CXCL8,TNF,CXCL2,BIRC5,NFKB2,PTGS2,RELA,CFLAR,IKBKB,IL6,BIRC3,CCND1,IL1A,TNFRSF1A,REL,VCAM1,IL1B,IL2,SELE,BIRC2,MMP3,RELB,NFKB1,BCL2A1,EGLN2,CSF2,VEGFA,MMP2,ICAM1,MMP9
WP2118	Arrhythmogenic Right Ventricular Cardiomyopathy	0.239894736023093	-1.427555051757	76	70	0.0148399406402374	4717	5310	81,3691,776,10369,6442,71,2697,1829,29119,1495,3695,27092,22801,87,3672,3728,785,27091,3655,59285,6444,100126325,1000,3680,781,3674,93589,1499,1605,3693,1496,10368,3696,6546,3908,3675,89,779,60,1824,3685,4000,55799,783,6934,59283,488,1674,8516,9254,6445,1832,3673,3676,59284,3688,3694,83439,6262,786,3690,5318,3679,784,6443,8515,6932,775,88,51176	ACTN4,ITGB4,CACNA1D,CACNG2,SGCA,ACTG1,GJA1,DSG2,CTNNA3,CTNNA1,ITGB7,CACNG4,ITGA11,ACTN1,ITGA1,JUP,CACNB4,CACNG5,ITGA6,CACNG6,SGCD,MIR935,CDH2,ITGA9,CACNA2D1,ITGA2B,CACNA2D4,CTNNB1,DAG1,ITGB5,CTNNA2,CACNG3,ITGB8,SLC8A1,LAMA2,ITGA3,ACTN3,CACNA1S,ACTB,DSC2,ITGAV,LMNA,CACNA2D3,CACNB2,TCF7L2,CACNG8,ATP2A2,DES,ITGA8,CACNA2D2,SGCG,DSP,ITGA2,ITGA4,CACNG7,ITGB1,ITGB6,TCF7L1,RYR2,CACNG1,ITGB3,PKP2,ITGA7,CACNB3,SGCB,ITGA10,TCF7,CACNA1C,ACTN2,LEF1
WP3301	MFAP5-mediated ovarian cancer cell motility and invasiveness	0.241088561251574	-1.42259093892062	12	12	0.0025439898240407	4717	5310	5588,3710,6263,3725,5594,5747,7134,3690,9586,3685,8076,5335	PRKCQ,ITPR3,RYR3,JUN,MAPK1,PTK2,TNNC1,ITGB3,CREB5,ITGAV,MFAP5,PLCG1
WP2007	Iron metabolism in placenta	0.241088561251574	-1.42259093892062	12	12	0.0025439898240407	4717	5310	7018,4891,57192,7037,7036,3658,57817,55240,341208,48,2495,30061	TF,SLC11A2,MCOLN1,TFRC,TFR2,IREB2,HAMP,STEAP3,HEPHL1,ACO1,FTH1,SLC40A1
WP2290	RalA downstream regulated genes	0.241088561251574	-1.42259093892062	12	12	0.0025439898240407	4717	5310	3845,55770,8531,3265,5879,5880,4893,5881,10928,998,149371,5898	KRAS,EXOC2,YBX3,HRAS,RAC1,RAC2,NRAS,RAC3,RALBP1,CDC42,EXOC8,RALA
WP1425	Bone Morphogenic Protein (BMP) Signalling and Regulation	0.241088561251574	-1.42259093892062	12	12	0.0025439898240407	4717	5310	860,10140,659,4086,10766,4089,4091,57154,650,657,658,9241	RUNX2,TOB1,BMPR2,SMAD1,TOB2,SMAD4,SMAD6,SMURF1,BMP2,BMPR1A,BMPR1B,NOG
WP395	IL-4 Signaling Pathway	0.248946655319246	-1.39051664113485	55	51	0.010811956752173	4717	5310	6778,2242,6776,867,9846,1386,3635,5777,5595,3269,3551,1050,2033,5290,3718,7297,3716,207,6198,6777,1051,1432,2885,9021,9655,6464,3667,1147,6774,2625,4792,5295,6654,332,3566,5970,5594,9046,8651,2353,5781,4783,3717,8660,100302237,3565,5600,5296,6772,4790,5293	STAT6,FES,STAT5A,CBL,GAB2,ATF2,INPP5D,PTPN6,MAPK3,HRH1,IKBKB,CEBPA,EP300,PIK3CA,JAK3,TYK2,JAK1,AKT1,RPS6KB1,STAT5B,CEBPB,MAPK14,GRB2,SOCS3,SOCS5,SHC1,IRS1,CHUK,STAT3,GATA3,NFKBIA,PIK3R1,SOS1,BIRC5,IL4R,RELA,MAPK1,DOK2,SOCS1,FOS,PTPN11,NFIL3,JAK2,IRS2,MIR1281,IL4,MAPK11,PIK3R2,STAT1,NFKB1,PIK3CD
WP2272	Pathogenic Escherichia coli infection	0.248946655319246	-1.39051664113485	55	51	0.010811956752173	4717	5310	7100,8976,7099,2017,8440,998,84790,10094,25,203068,4690,51807,3059,3688,347733,7534,347688,7278,7430,387,10552,81027,3875,60,81873,10376,10093,7846,10971,10109,79861,1499,112714,10382,10095,2534,9181,9475,100506658,999,5578,7277,9076,71,929,10092,4691,7280,84617,23643,10381	TLR5,WASL,TLR4,CTTN,NCK2,CDC42,TUBA1C,ARPC3,ABL1,TUBB,NCK1,TUBA8,HCLS1,ITGB1,TUBB2B,YWHAZ,TUBB8,TUBA3C,EZR,RHOA,ARPC1A,TUBB1,KRT18,ACTB,ARPC5L,TUBA1B,ARPC4,TUBA1A,YWHAQ,ARPC2,TUBAL3,CTNNB1,TUBA3E,TUBB4A,ARPC1B,FYN,ARHGEF2,ROCK2,OCLN,CDH1,PRKCA,TUBA4A,CLDN1,ACTG1,CD14,ARPC5,NCL,TUBB2A,TUBB6,LY96,TUBB3
WP313	Signaling of Hepatocyte Growth Factor Receptor	0.251379301492376	-1.38079231918142	34	32	0.00678397286410854	4717	5310	5921,5594,4233,2353,5829,2889,5781,3672,5290,2185,5894,5599,5058,5604,2549,3265,5728,5605,3082,3725,1398,2885,11184,1793,6714,3688,6774,5908,5747,5906,5595,6654	RASA1,MAPK1,MET,FOS,PXN,RAPGEF1,PTPN11,ITGA1,PIK3CA,PTK2B,RAF1,MAPK8,PAK1,MAP2K1,GAB1,HRAS,PTEN,MAP2K2,HGF,JUN,CRK,GRB2,MAP4K1,DOCK1,SRC,ITGB1,STAT3,RAP1B,PTK2,RAP1A,MAPK3,SOS1
WP1601	Fluoropyrimidine Activity	0.251379301492376	-1.38079231918142	34	32	0.00678397286410854	4717	5310	6241,4524,8714,6996,1066,7083,10864,978,1719,8836,23583,7378,2068,7372,10057,5471,6240,83549,1807,7157,1548,1806,10257,7517,7371,151531,2030,9429,100500832,51733,7298,8824	RRM2,MTHFR,ABCC3,TDG,CES1,TK1,SLC22A7,CDA,DHFR,GGH,SMUG1,UPP1,ERCC2,UMPS,ABCC5,PPAT,RRM1,UCK1,DPYS,TP53,CYP2A6,DPYD,ABCC4,XRCC3,UCK2,UPP2,SLC29A1,ABCG2,MIR3658,UPB1,TYMS,CES2
WP3612	Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling	0.254773122780174	-1.36738184444221	23	22	0.00466398134407462	4717	5310	2729,2052,4835,1066,3725,6300,9817,8714,1432,1728,3162,2730,1244,5600,9429,5599,10257,4780,140809,2950,5603,2353	GCLC,EPHX1,NQO2,CES1,JUN,MAPK12,KEAP1,ABCC3,MAPK14,NQO1,HMOX1,GCLM,ABCC2,MAPK11,ABCG2,MAPK8,ABCC4,NFE2L2,SRXN1,GSTP1,MAPK13,FOS
WP2572	Primary Focal Segmental Glomerulosclerosis FSGS	0.265106890128674	-1.32762217534715	74	68	0.0144159423362307	4717	5310	3685,207,7402,3675,11346,1514,5111,4040,4690,7225,3690,941,5747,3688,4643,5420,1378,50485,84623,4868,7099,4288,7040,1028,1026,4311,950,3856,3691,100616340,5800,81,1759,4010,7827,816,2195,1286,375790,3611,9076,3913,3987,7471,7490,1000,3664,977,182,3911,5335,5076,64423,10971,4627,4041,1605,5329,1285,7431,7414,55742,1027,1499,22943,51196,2534,23607	ITGAV,AKT1,UTRN,ITGA3,SYNPO,CTSL,PCNA,LRP6,NCK1,TRPC6,ITGB3,CD80,PTK2,ITGB1,MYO1E,PODXL,CR1,SMARCAL1,KIRREL3,NPHS1,TLR4,MKI67,TGFB1,CDKN1C,CDKN1A,MME,SCARB2,KRT8,ITGB4,MIR4758,PTPRO,ACTN4,DNM1,LMX1B,NPHS2,CAMK2B,FAT1,COL4A4,AGRN,ILK,CLDN1,LAMB2,LIMS1,WNT1,WT1,CDH2,IRF6,CD151,JAG1,LAMA5,PLCG1,PAX2,INF2,YWHAQ,MYH9,LRP5,DAG1,PLAUR,COL4A3,VIM,VCL,PARVA,CDKN1B,CTNNB1,DKK1,PLCE1,FYN,CD2AP
WP3676	BDNF-TrkB Signaling	0.270133606801728	-1.3088386023703	33	31	0.00657197371210515	4717	5310	1385,207,2549,3265,3845,5604,5594,7249,6195,7248,107,5294,2475,1742,673,5335,23237,6009,29904,7225,6654,1978,6198,9456,7222,627,4915,2885,4893,6464,9846	CREB1,AKT1,GAB1,HRAS,KRAS,MAP2K1,MAPK1,TSC2,RPS6KA1,TSC1,ADCY1,PIK3CG,MTOR,DLG4,BRAF,PLCG1,ARC,RHEB,EEF2K,TRPC6,SOS1,EIF4EBP1,RPS6KB1,HOMER1,TRPC3,BDNF,NTRK2,GRB2,NRAS,SHC1,GAB2
WP3630	NAD metabolism, sirtuins and aging	0.271467974090989	-1.30391110571509	11	11	0.00233199067203731	4717	5310	4790,23411,10135,2309,142,2308,3091,6098,7019,23410,5468	NFKB1,SIRT1,NAMPT,FOXO3,PARP1,FOXO1,HIF1A,ROS1,TFAM,SIRT3,PPARG
WP2513	Nanoparticle triggered regulated necrosis	0.271467974090989	-1.30391110571509	11	11	0.00233199067203731	4717	5310	8772,7132,5321,2512,5599,142,148022,11035,8717,841,8737	FADD,TNFRSF1A,PLA2G4A,FTL,MAPK8,PARP1,TICAM1,RIPK3,TRADD,CASP8,RIPK1
WP75	Toll-like Receptor Signaling Pathway	0.271530729459172	-1.30367996200129	103	94	0.0199279202883188	4717	5310	29110,929,4615,6772,5296,23643,5594,3592,3569,5295,3445,23533,5970,51135,7189,6300,942,3441,1432,6885,3627,5291,5879,10454,9641,3440,114609,5609,8772,3444,841,5290,5603,5294,5608,5595,941,3551,7096,23118,10333,10000,3663,7187,3442,3443,3448,5600,4790,3449,8503,5293,5604,3452,54472,958,2353,4792,5602,3439,148022,6351,3725,3576,6416,7097,3454,1147,3455,3929,8737,207,5599,6696,208,3661,353376,3665,5606,3553,6352,4791,3593,5601,3456,6348,54106,5605,7124,7098,6373,7099,7100,1326	TBK1,CD14,MYD88,STAT1,PIK3R2,LY96,MAPK1,IL12A,IL6,PIK3R1,IFNA8,PIK3R5,RELA,IRAK4,TRAF6,MAPK12,CD86,IFNA4,MAPK14,MAP3K7,CXCL10,PIK3CB,RAC1,TAB1,IKBKE,IFNA2,TIRAP,MAP2K7,FADD,IFNA7,CASP8,PIK3CA,MAPK13,PIK3CG,MAP2K6,MAPK3,CD80,IKBKB,TLR1,TAB2,TLR6,AKT3,IRF5,TRAF3,IFNA5,IFNA6,IFNA14,MAPK11,NFKB1,IFNA16,PIK3R3,PIK3CD,MAP2K1,IFNA21,TOLLIP,CD40,FOS,NFKBIA,MAPK10,IFNA1,TICAM1,CCL4,JUN,CXCL8,MAP2K4,TLR2,IFNAR1,CHUK,IFNAR2,LBP,RIPK1,AKT1,MAPK8,SPP1,AKT2,IRF3,TICAM2,IRF7,MAP2K3,IL1B,CCL5,NFKB2,IL12B,MAPK9,IFNB1,CCL3,TLR9,MAP2K2,TNF,TLR3,CXCL11,TLR4,TLR5,MAP3K8
WP3599	Transcription factor regulation in adipogenesis	0.277627393943341	-1.28147537386608	22	21	0.00445198219207123	4717	5310	23175,7124,7291,5468,8204,2908,1051,1050,3667,1052,3952,6517,3569,3643,8660,6256,2308,5599,9370,10891,1385	LPIN1,TNF,TWIST1,PPARG,NRIP1,NR3C1,CEBPB,CEBPA,IRS1,CEBPD,LEP,SLC2A4,IL6,INSR,IRS2,RXRA,FOXO1,MAPK8,ADIPOQ,PPARGC1A,CREB1
WP3645	NAD+ biosynthetic pathways	0.277627393943341	-1.28147537386608	22	21	0.00445198219207123	4717	5310	142,10135,3620,10038,23411,80351,952,23409,683,51547,22933,8658,130013,51548,55191,64802,23408,143,23410,6999,23475	PARP1,NAMPT,IDO1,PARP2,SIRT1,TNKS2,CD38,SIRT4,BST1,SIRT7,SIRT2,TNKS,ACMSD,SIRT6,NADSYN1,NMNAT1,SIRT5,PARP4,SIRT3,TDO2,QPRT
WP1424	Globo Sphingolipid Metabolism	0.277627393943341	-1.28147537386608	22	21	0.00445198219207123	4717	5310	30815,84620,27090,8706,55808,6489,10610,6483,10317,53947,6482,256435,2590,10690,2650,2524,26301,127550,81849,6480,28	ST6GALNAC6,ST6GAL2,ST6GALNAC4,B3GALNT1,ST6GALNAC1,ST8SIA1,ST6GALNAC2,ST3GAL2,B3GALT5,A4GALT,ST3GAL1,ST6GALNAC3,GALNT2,FUT9,GCNT1,FUT2,GBGT1,A3GALT2,ST6GALNAC5,ST6GAL1,ABO
WP167	Eicosanoid Synthesis	0.277627393943341	-1.28147537386608	22	21	0.00445198219207123	4717	5310	92086,246,50640,5740,239,5742,240,8398,2678,80142,4048,5743,9536,91227,1800,4056,80339,241,5320,247,6916	GGTLC1,ALOX15,PNPLA8,PTGIS,ALOX12,PTGS1,ALOX5,PLA2G6,GGT1,PTGES2,LTA4H,PTGS2,PTGES,GGTLC2,DPEP1,LTC4S,PNPLA3,ALOX5AP,PLA2G2A,ALOX15B,TBXAS1
WP43	Oxidation by Cytochrome P450	0.279405623830557	-1.27509070412077	63	58	0.0122959508161967	4717	5310	51302,1591,1558,1553,1727,51700,1562,199974,10858,1559,56603,66002,57834,1572,51706,260293,1582,1595,120227,1555,1577,339761,1593,8529,64816,1580,1584,22952,1544,1557,284541,1585,1545,57404,51167,1592,113612,5447,126410,80777,1565,54905,1581,29785,1594,1549,285440,1579,1573,1586,1576,11283,1543,1583,1548,9420,1588,1528	CYP39A1,CYP24A1,CYP2C8,CYP2A13,CYB5R3,CYB5R2,CYP2C18,CYP4Z1,CYP46A1,CYP2C9,CYP26B1,CYP4F12,CYP4F11,CYP2F1,CYB5R1,CYP4X1,CYP8B1,CYP51A1,CYP2R1,CYP2B6,CYP3A5,CYP27C1,CYP27A1,CYP4F2,CYP3A43,CYP4B1,CYP11B1,CYP2G1P,CYP1A2,CYP2C19,CYP4A22,CYP11B2,CYP1B1,CYP20A1,CYB5R4,CYP26A1,CYP2U1,POR,CYP4F22,CYB5B,CYP2D6,CYP2W1,CYP7A1,CYP2S1,CYP27B1,CYP2A7,CYP4V2,CYP4A11,CYP2J2,CYP17A1,CYP3A4,CYP4F8,CYP1A1,CYP11A1,CYP2A6,CYP7B1,CYP19A1,CYB5A
WP2064	Neural Crest Differentiation	0.28299815858757	-1.26231488811777	102	93	0.0197159211363155	4717	5310	4286,6615,3975,2932,8841,9759,6662,2637,1749,1856,9734,8929,3688,4359,4762,4155,6660,1005,388,2247,54567,10014,10683,4487,1855,3198,3065,7545,1499,167826,89780,1004,1000,388585,7478,1638,655,5081,64211,2263,3066,8312,429,4853,4602,283659,4488,9965,4609,3516,7976,652,8313,83439,4791,1488,7020,85416,27022,5077,2253,4854,51564,9355,6911,1280,23493,2260,83933,3196,2670,3670,9421,79885,7291,6591,3280,5376,1857,2113,4855,999,2261,6925,7471,1302,127343,6663,4790,4086,3211,7021,10215	MITF,SNAI1,LHX1,GSK3B,HDAC3,HDAC4,SOX9,GBX2,DLX5,DVL2,HDAC9,PHOX2B,ITGB1,MPZ,NEUROG1,MBP,SOX5,CDH7,RHOB,FGF2,DLL4,HDAC5,DLL3,MSX1,DVL1,HOXA1,HDAC1,ZIC1,CTNNB1,OLIG3,WNT3A,CDH6,CDH2,HES5,WNT8A,DCT,BMP7,PAX7,LHX5,FGFR2,HDAC2,AXIN1,ASCL1,NOTCH2,MYB,PRTG,MSX2,FGF19,MYC,RBPJ,FZD3,BMP4,AXIN2,TCF7L1,NFKB2,CTBP2,TFAP2A,ZIC5,FOXD3,PAX3,FGF8,NOTCH3,HDAC7,LHX2,TBX6,COL2A1,HEY2,FGFR1,HDAC10,TLX2,GFAP,ISL1,HAND1,HDAC11,TWIST1,SNAI2,HES1,PMP22,DVL3,ETS1,NOTCH4,CDH1,FGFR3,TCF4,WNT1,COL11A2,DMBX1,SOX10,NFKB1,SMAD1,HOXB1,TFAP2B,OLIG2
WP3893	Development and heterogeneity of the ILC family	0.289969002854082	-1.23798124842447	32	30	0.00635997456010176	4717	5310	6095,85480,30009,3565,50616,4783,196,64919,3553,3605,3398,3592,9760,90865,3593,3567,2672,3596,3458,3600,7704,3574,2625,3569,8320,6927,374,3606,3578,7124	RORA,TSLP,TBX21,IL4,IL22,NFIL3,AHR,BCL11B,IL1B,IL17A,ID2,IL12A,TOX,IL33,IL12B,IL5,GFI1,IL13,IFNG,IL15,ZBTB16,IL7,GATA3,IL6,EOMES,HNF1A,AREG,IL18,IL9,TNF
WP34	Ovarian Infertility Genes	0.289969002854082	-1.23798124842447	32	30	0.00635997456010176	4717	5310	4292,1958,8204,2701,3973,2492,1588,23224,9611,4088,894,5618,7421,6609,1618,2516,2661,3623,344018,7784,1051,5732,658,1027,472,11144,2100,7783,1019,5241	MLH1,EGR1,NRIP1,GJA4,LHCGR,FSHR,CYP19A1,SYNE2,NCOR1,SMAD3,CCND2,PRLR,VDR,SMPD1,DAZL,NR5A1,GDF9,INHA,FIGLA,ZP3,CEBPB,PTGER2,BMPR1B,CDKN1B,ATM,DMC1,ESR2,ZP2,CDK4,PGR
WP727	Monoamine Transport	0.289969002854082	-1.23798124842447	32	30	0.00635997456010176	4717	5310	273,1621,3690,10497,4982,6999,7124,10066,43,6530,114907,1432,135,121278,5819,60482,3554,5934,11255,7249,6531,7054,995,183,6529,4842,6532,3553,5516,7041	AMPH,DBH,ITGB3,UNC13B,TNFRSF11B,TDO2,TNF,SCAMP2,ACHE,SLC6A2,FBXO32,MAPK14,ADORA2A,TPH2,NECTIN2,SLC5A7,IL1R1,RBL2,HRH3,TSC2,SLC6A3,TH,CDC25C,AGT,SLC6A1,NOS1,SLC6A4,IL1B,PPP2CB,TGFB1I1
WP61	Notch Signaling Pathway	0.294166378426127	-1.2236097586978	62	57	0.0120839516641933	4717	5310	207,23493,54567,9612,10683,2033,4854,55502,5663,1840,23013,171558,3091,6714,4137,4609,2932,8650,55534,1026,3516,4790,5296,4853,3932,23462,6868,55294,9611,9253,6500,3717,5664,8819,100302237,9541,9794,8454,3714,6015,23385,3066,3280,7088,51107,182,83464,388585,4855,6774,22938,83737,5295,2625,595,3065,84441	AKT1,HEY2,DLL4,NCOR2,DLL3,EP300,NOTCH3,HES6,PSEN1,DTX1,SPEN,PTCRA,HIF1A,SRC,MAPT,MYC,GSK3B,NUMB,MAML3,CDKN1A,RBPJ,NFKB1,PIK3R2,NOTCH2,LCK,HEY1,ADAM17,FBXW7,NCOR1,NUMBL,SKP1,JAK2,PSEN2,SAP30,MIR1281,CIR1,MAML1,CUL1,JAG2,RING1,NCSTN,HDAC2,HES1,TLE1,APH1A,JAG1,APH1B,HES5,NOTCH4,STAT3,SNW1,ITCH,PIK3R1,GATA3,CCND1,HDAC1,MAML2
WP3584	MECP2 and Associated Rett Syndrome	0.294166378426127	-1.2236097586978	62	57	0.0120839516641933	4717	5310	4986,1465,54715,3187,1750,4155,2475,4099,7337,1267,6670,1385,2247,207,6667,604,6750,80312,4661,2571,9315,50937,10664,54790,6446,5978,1052,6194,1749,815,2146,4208,4904,1869,5454,2570,6890,200424,2593,2890,9126,2894,4763,26084,5457,2249,2289,2248,84950,9611,3185,2250,2530,25942,3481,627,3065	OPRK1,CSRP1,RBFOX1,HNRNPH1,DLX6,MBP,MTOR,MAG,UBE3A,CNP,SP3,CREB1,FGF2,AKT1,SP1,BCL6,SST,TET1,MYT1,GAD1,NREP,CDON,CTCF,TET2,SGK1,REST,CEBPD,RPS6,DLX5,CAMK2A,EZH2,MEF2C,YBX1,E2F1,POU3F2,GABRR2,TAP1,TET3,GAMT,GRIA1,SMC3,GRID1,NF1,ARHGEF26,POU4F1,FGF4,FKBP5,FGF3,PRPF38A,NCOR1,HNRNPF,FGF5,FUT8,SIN3A,IGF2,BDNF,HDAC1
WP691	Tamoxifen metabolism	0.302187762306332	-1.19670672530981	21	20	0.00423998304006784	4717	5310	54657,1577,6822,6817,1548,1543,6783,1576,1559,7366,1557,1558,1545,54575,1565,1544,2328,54576,2326,7364	UGT1A4,CYP3A5,SULT2A1,SULT1A1,CYP2A6,CYP1A1,SULT1E1,CYP3A4,CYP2C9,UGT2B15,CYP2C19,CYP2C8,CYP1B1,UGT1A10,CYP2D6,CYP1A2,FMO3,UGT1A8,FMO1,UGT2B7
WP2874	Liver X Receptor Pathway	0.305668209616306	-1.18525504758873	10	10	0.00211999152003392	4717	5310	6256,1555,2194,1581,64241,10062,1576,6720,6319,64240	RXRA,CYP2B6,FASN,CYP7A1,ABCG8,NR1H3,CYP3A4,SREBF1,SCD,ABCG5
WP704	Methylation Pathways	0.305668209616306	-1.18525504758873	10	10	0.00211999152003392	4717	5310	4143,3176,11185,4144,1312,27430,7172,4837,5409,100616414	MAT1A,HNMT,INMT,MAT2A,COMT,MAT2B,TPMT,NNMT,PNMT,MIR4761
WP496	Steroid Biosynthesis	0.305668209616306	-1.18525504758873	10	10	0.00211999152003392	4717	5310	3292,2165,3295,3283,3284,3294,1586,51478,3293,1369	HSD17B1,F13B,HSD17B4,HSD3B1,HSD3B2,HSD17B2,CYP17A1,HSD17B7,HSD17B3,CPN1
WP3865	RIG-I-like Receptor Signaling	0.309445783669817	-1.17297237612851	61	56	0.01187195251219	4717	5310	1540,29110,80143,4790,5600,10010,22938,5602,4792,3439,8717,5970,7706,7189,3576,64343,6387,10521,56832,6300,843,1432,3627,6885,1147,338376,8737,340061,9641,9474,3661,5599,79132,9140,23586,8772,3665,57506,9636,841,9755,4793,26007,5603,100500827,79671,3458,54941,5601,3456,3551,5300,4214,64135,7124,7187	CYLD,TBK1,SIKE1,NFKB1,MAPK11,TANK,SNW1,MAPK10,NFKBIA,IFNA1,TRADD,RELA,TRIM25,TRAF6,CXCL8,AZI2,CXCL12,DDX17,IFNK,MAPK12,CASP10,MAPK14,CXCL10,MAP3K7,CHUK,IFNE,RIPK1,STING1,IKBKE,ATG5,IRF3,MAPK8,DHX58,ATG12,RIGI,FADD,IRF7,MAVS,ISG15,CASP8,TBKBP1,NFKBIB,TKFC,MAPK13,MIR3614,NLRX1,IFNG,RNF125,MAPK9,IFNB1,IKBKB,PIN1,MAP3K1,IFIH1,TNF,TRAF3
WP2112	IL17 signaling pathway	0.310905013753228	-1.16826783546905	31	29	0.00614797540809837	4717	5310	5594,3605,4793,9020,3717,3716,207,4790,6667,54756,7189,10758,55540,27189,1051,23765,132014,6885,112744,1052,7187,2932,6774,53342,5595,84818,3551,27190,5970	MAPK1,IL17A,NFKBIB,MAP3K14,JAK2,JAK1,AKT1,NFKB1,SP1,IL17RD,TRAF6,TRAF3IP2,IL17RB,IL17C,CEBPB,IL17RA,IL17RE,MAP3K7,IL17F,CEBPD,TRAF3,GSK3B,STAT3,IL17D,MAPK3,IL17RC,IKBKB,IL17B,RELA
WP408	Oxidative Stress	0.310905013753228	-1.16826783546905	31	29	0.00614797540809837	4717	5310	6649,1535,2353,3726,847,4501,4257,2876,4784,1543,6647,4780,50507,6648,2878,6667,25828,2953,10587,4790,7296,2936,1432,3162,1728,7498,54578,2729,5602	SOD3,CYBA,FOS,JUNB,CAT,MT1X,MGST1,GPX1,NFIX,CYP1A1,SOD1,NFE2L2,NOX4,SOD2,GPX3,SP1,TXN2,GSTT2,TXNRD2,NFKB1,TXNRD1,GSR,MAPK14,HMOX1,NQO1,XDH,UGT1A6,GCLC,MAPK10
WP3611	Photodynamic therapy-induced AP-1 survival signaling.	0.311857226137439	-1.16520980444124	51	47	0.00996396014415942	4717	5310	5609,4780,602,596,5606,5603,1956,890,5608,3558,5156,4313,4170,3320,598,5599,5925,898,7124,1026,4217,1029,90427,7132,1386,3458,355,7157,578,356,2353,2252,3726,5600,3725,7189,6416,6300,1432,10018,7188,581,3569,595,8743,8837,1839	MAP2K7,NFE2L2,BCL3,BCL2,MAP2K3,MAPK13,EGFR,CCNA2,MAP2K6,IL2,PDGFRA,MMP2,MCL1,HSP90AA1,BCL2L1,MAPK8,RB1,CCNE1,TNF,CDKN1A,MAP3K5,CDKN2A,BMF,TNFRSF1A,ATF2,IFNG,FAS,TP53,BAK1,FASLG,FOS,FGF7,JUNB,MAPK11,JUN,TRAF6,MAP2K4,MAPK12,MAPK14,BCL2L11,TRAF5,BAX,IL6,CCND1,TNFSF10,CFLAR,HBEGF
WP2328	Allograft Rejection	0.316247661737352	-1.15122963268362	80	73	0.0154759380962476	4717	5310	3105,55825,3112,3552,100507436,120892,10563,7431,6387,10578,3576,3586,942,3133,1493,940,3123,842,1459,3109,3565,836,840,718,2668,3108,6772,3106,3135,23743,1289,3592,5590,2551,958,356,3117,3002,59067,643,3458,355,3134,3596,727,6366,3111,3567,3593,941,6363,7124,6373,3122,7040,720,5551,7422,50616,3127,10376,3107,5243,3559,3119,3113,841,3118,185,3605,3553,3558,5156	HLA-A,PECR,HLA-DOB,IL1A,MICA,LRRK2,CXCL13,VIM,CXCL12,GNLY,CXCL8,IL10,CD86,HLA-E,CTLA4,CD28,HLA-DRB1,CASP9,CSNK2A2,HLA-DMB,IL4,CASP3,CASP7,C3,GDNF,HLA-DMA,STAT1,HLA-B,HLA-G,BHMT2,COL5A1,IL12A,PRKCZ,GABPA,CD40,FASLG,HLA-DQA1,GZMB,IL21,CXCR5,IFNG,FAS,HLA-F,IL13,C5,CCL21,HLA-DOA,IL5,IL12B,CD80,CCL19,TNF,CXCL11,HLA-DRA,TGFB1,C4A,PRF1,VEGFA,IL22,HLA-DRB5,TUBA1B,HLA-C,ABCB1,IL2RA,HLA-DQB1,HLA-DPA1,CASP8,HLA-DQA2,AGTR1,IL17A,IL1B,IL2,PDGFRA
WP558	Complement and Coagulation Cascades	0.325238940392983	-1.12319516557124	60	55	0.0116599533601866	4717	5310	2161,7056,1604,5648,462,1361,719,1213,2244,2165,629,3053,2149,715,5265,1378,728,5327,5104,735,2152,5340,5345,2153,5624,730,718,714,2159,3998,717,4179,712,1191,5627,716,3426,710,7450,5054,623,7035,3075,3818,1675,2155,713,2147,2,729,5328,10747,1380,3827,5329	F12,THBD,CD55,MASP1,SERPINC1,CPB2,C3AR1,CLTC,FGB,F13B,CFB,SERPIND1,F2R,C1R,SERPINA1,CR1,C5AR1,PLAT,SERPINA5,C9,F3,PLG,SERPINF2,F5,PROC,C7,C3,C1QC,F10,LMAN1,C2,CD46,C1QA,CLU,PROS1,C1S,CFI,SERPING1,VWF,SERPINE1,BDKRB1,TFPI,CFH,KLKB1,CFD,F7,C1QB,F2,A2M,C6,PLAU,MASP2,CR2,KNG1,PLAUR
WP3527	Preimplantation Embryo	0.325238940392983	-1.12319516557124	60	55	0.0116599533601866	4717	5310	359787,1045,284355,678,360,30812,8570,366,2354,2101,1958,6664,6597,2624,4084,79923,5460,126206,5087,1746,55509,360030,7004,503834,55506,83439,353238,4603,3159,11189,7080,4342,7021,94234,3662,9314,57504,132625,4306,100500888,326340,201516,999,29947,2625,476,6496,1875,10265,7538,342900,1994,8538,6657,6926	DPPA3,CDX2,TPRX1,ZFP36L2,AQP3,SOX8,KHSRP,AQP9,FOSB,ESRRA,EGR1,SOX11,SMARCA4,GATA2,MXD1,NANOG,POU5F1,NLRP5,PBX1,DLX2,BATF3,NANOGNB,TEAD4,DPRX,MACROH2A2,TCF7L1,PADI6,MYBL1,HMGA1,CELF3,NKX2-1,MOS,TFAP2B,FOXQ1,IRF4,KLF4,MTA3,ZFP42,NR3C2,MIR3940,ZAR1,ZSCAN4,CDH1,DNMT3L,GATA3,ATP1A1,SIX3,E2F5,IRX5,ZFP36,LEUTX,ELAVL1,BARX2,SOX2,TBX3
WP3844	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities	0.332954662170784	-1.09974894790818	30	28	0.00593597625609498	4717	5310	6009,5295,2308,253260,4846,2309,5163,57521,5728,1027,1978,8408,2932,5291,4893,3845,7942,3265,5296,207,8503,7249,2887,9821,2475,9776,5294,5290	RHEB,PIK3R1,FOXO1,RICTOR,NOS3,FOXO3,PDK1,RPTOR,PTEN,CDKN1B,EIF4EBP1,ULK1,GSK3B,PIK3CB,NRAS,KRAS,TFEB,HRAS,PIK3R2,AKT1,PIK3R3,TSC2,GRB10,RB1CC1,MTOR,ATG13,PIK3CG,PIK3CA
WP531	Mismatch repair	0.344168899570157	-1.06662275498093	9	9	0.00190799236803053	4717	5310	5111,3978,4436,5424,6117,5981,9156,2956,4292	PCNA,LIG1,MSH2,POLD1,RPA1,RFC1,EXO1,MSH6,MLH1
WP3875	ATR Signaling	0.344168899570157	-1.06662275498093	9	9	0.00190799236803053	4717	5310	5810,11073,1111,6117,3364,144715,84126,5883,545	RAD1,TOPBP1,CHEK1,RPA1,HUS1,RAD9B,ATRIP,RAD9A,ATR
WP3593	miR-148a/miR-31/FIH1/HIF1α-Notch signaling in glioblastoma	0.344168899570157	-1.06662275498093	9	9	0.00190799236803053	4717	5310	7423,3280,406940,407035,7424,55662,23462,3091,7422	VEGFB,HES1,MIR148A,MIR31,VEGFC,HIF1AN,HEY1,HIF1A,VEGFA
WP696	Benzo(a)pyrene metabolism	0.344168899570157	-1.06662275498093	9	9	0.00190799236803053	4717	5310	1543,1576,1109,1646,1545,10327,2052,1645,8644	CYP1A1,CYP3A4,AKR1C4,AKR1C2,CYP1B1,AKR1A1,EPHX1,AKR1C1,AKR1C3
WP3674	Tgif disruption of Shh signaling	0.344168899570157	-1.06662275498093	9	9	0.00190799236803053	4717	5310	7050,6469,2290,60436,4838,2737,2253,4087,7080	TGIF1,SHH,FOXG1,TGIF2,NODAL,GLI3,FGF8,SMAD2,NKX2-1
WP3300	Dual hijack model of Vif in HIV infection	0.344168899570157	-1.06662275498093	9	9	0.00190799236803053	4717	5310	6923,861,6921,60489,9978,100506403,865,8065,7314	ELOB,RUNX1,ELOC,APOBEC3G,RBX1,LOC100506403,CBFB,CUL5,UBB
WP534	Glycolysis and Gluconeogenesis	0.347076374483003	-1.05821042387894	49	45	0.00953996184015264	4717	5310	7167,229,2023,26330,2538,2026,5313,4191,51660,3945,3939,5315,5214,1738,6517,5223,5091,5162,3948,92483,3098,6514,2597,3099,2027,5211,226,8789,2805,6515,3101,2821,2645,25874,6513,1737,2806,6518,5232,5105,4190,5161,2203,5224,8050	TPI1,ALDOB,ENO1,GAPDHS,G6PC1,ENO2,PKLR,MDH2,MPC1,LDHB,LDHA,PKM,PFKP,DLD,SLC2A4,PGAM1,PC,PDHB,LDHC,LDHAL6B,HK1,SLC2A2,GAPDH,HK2,ENO3,PFKL,ALDOA,FBP2,GOT1,SLC2A3,HK3,GPI,GCK,MPC2,SLC2A1,DLAT,GOT2,SLC2A5,PGK2,PCK1,MDH1,PDHA2,FBP1,PGAM2,PDHX
WP286	IL-3 Signaling Pathway	0.347076374483003	-1.05821042387894	49	45	0.00953996184015264	4717	5310	5599,1439,598,3265,207,3716,5894,1232,596,3562,4067,5777,5595,3635,6714,9846,7040,867,6776,5604,5293,5296,5566,3717,7529,5781,2889,2353,969,5594,3568,6654,6850,5295,5169,6774,7409,6464,2885,10971,942,2534,6777,3576,3725	MAPK8,CSF2RB,BCL2L1,HRAS,AKT1,JAK1,RAF1,CCR3,BCL2,IL3,LYN,PTPN6,MAPK3,INPP5D,SRC,GAB2,TGFB1,CBL,STAT5A,MAP2K1,PIK3CD,PIK3R2,PRKACA,JAK2,YWHAB,PTPN11,RAPGEF1,FOS,CD69,MAPK1,IL5RA,SOS1,SYK,PIK3R1,ENPP3,STAT3,VAV1,SHC1,GRB2,YWHAQ,CD86,FYN,STAT5B,CXCL8,JUN
WP3303	Rac1/Pak1/p38/MMP-2 pathway	0.351322142637506	-1.04605169113164	68	62	0.0131439474242103	4717	5310	5599,5058,3845,285,207,5888,3265,5879,1956,5603,5829,79155,5290,5921,3551,5747,5601,4690,10413,5595,6714,79931,3925,3688,2308,4609,2335,6776,9068,10318,840,5600,4790,7075,842,5781,4842,9046,5594,7157,2888,5970,332,6654,4792,284,5295,51378,4436,6774,7010,1147,1398,581,1432,2885,4893,6300,2064,1978,1499,6777	MAPK8,PAK1,KRAS,ANGPT2,AKT1,RAD51,HRAS,RAC1,EGFR,MAPK13,PXN,TNIP2,PIK3CA,RASA1,IKBKB,PTK2,MAPK9,NCK1,YAP1,MAPK3,SRC,TNIP3,STMN1,ITGB1,FOXO1,MYC,FN1,STAT5A,ANGPTL1,TNIP1,CASP7,MAPK11,NFKB1,TIE1,CASP9,PTPN11,NOS1,DOK2,MAPK1,TP53,GRB14,RELA,BIRC5,SOS1,NFKBIA,ANGPT1,PIK3R1,ANGPT4,MSH2,STAT3,TEK,CHUK,CRK,BAX,MAPK14,GRB2,NRAS,MAPK12,ERBB2,EIF4EBP1,CTNNB1,STAT5B
WP2643	Nanoparticle-mediated activation of receptor signaling	0.35612324797122	-1.0324784058779	29	27	0.00572397710409158	4717	5310	5600,3265,5599,3845,5604,5293,5894,5829,1956,5603,1277,3672,5594,6654,5601,5747,3688,6714,5602,1432,2885,10000,2335,4893,5605,6300,374	MAPK11,HRAS,MAPK8,KRAS,MAP2K1,PIK3CD,RAF1,PXN,EGFR,MAPK13,COL1A1,ITGA1,MAPK1,SOS1,MAPK9,PTK2,ITGB1,SRC,MAPK10,MAPK14,GRB2,AKT3,FN1,NRAS,MAP2K2,MAPK12,AREG
WP2583	T-Cell Receptor and Co-stimulatory Signaling	0.35612324797122	-1.0324784058779	29	27	0.00572397710409158	4717	5310	3558,7535,5578,5921,10125,801,4790,926,3932,207,8445,4773,940,2932,1493,805,2534,1452,2931,5728,3702,5777,5530,5163,4792,5335,1859	IL2,ZAP70,PRKCA,RASA1,RASGRP1,CALM1,NFKB1,CD8B,LCK,AKT1,DYRK2,NFATC2,CD28,GSK3B,CTLA4,CALM2,FYN,CSNK1A1,GSK3A,PTEN,ITK,PTPN6,PPP3CA,PDK1,NFKBIA,PLCG1,DYRK1A
WP734	Serotonin Receptor 4/6/7 and NR3C Signaling	0.356684181542205	-1.03090453427233	19	18	0.00381598473606106	4717	5310	3363,1958,5594,2778,5605,6722,2908,9252,5906,5595,466,1385,9261,3360,5604,673,2005,3362	HTR7,EGR1,MAPK1,GNAS,MAP2K2,SRF,NR3C1,RPS6KA5,RAP1A,MAPK3,ATF1,CREB1,MAPKAPK2,HTR4,MAP2K1,BRAF,ELK4,HTR6
WP247	Small Ligand GPCRs	0.356684181542205	-1.03090453427233	19	18	0.00381598473606106	4717	5310	5739,4544,1268,1903,5724,1269,5737,9294,5733,6915,4543,8698,5732,1901,5729,1902,5734,5731	PTGIR,MTNR1B,CNR1,S1PR3,PTAFR,CNR2,PTGFR,S1PR2,PTGER3,TBXA2R,MTNR1A,S1PR4,PTGER2,S1PR1,PTGDR,LPAR1,PTGER4,PTGER1
WP2879	Farnesoid X Receptor  Pathway	0.356684181542205	-1.03090453427233	19	18	0.00381598473606106	4717	5310	1582,8647,10891,11309,570,1581,117283,2289,6256,5244,8660,8431,7363,9965,6554,9971,1576,6822	CYP8B1,ABCB11,PPARGC1A,SLCO2B1,BAAT,CYP7A1,IP6K3,FKBP5,RXRA,ABCB4,IRS2,NR0B2,UGT2B4,FGF19,SLC10A1,NR1H4,CYP3A4,SULT2A1
WP2011	SREBF and miR33 in cholesterol and lipid homeostasis	0.356684181542205	-1.03090453427233	19	18	0.00381598473606106	4717	5310	3156,407039,3157,51586,5562,6720,693120,3949,51548,2475,5465,6319,6721,19,2194,10062,10891,23411	HMGCR,MIR33A,HMGCS1,MED15,PRKAA1,SREBF1,MIR33B,LDLR,SIRT6,MTOR,PPARA,SCD,SREBF2,ABCA1,FASN,NR1H3,PPARGC1A,SIRT1
WP560	TGF-beta Receptor Signaling	0.358334193697324	-1.02628922607558	58	53	0.0112359550561798	4717	5310	2280,2033,25805,9839,3976,4093,9241,6696,4087,3265,3716,864,7040,10637,51176,7044,7124,6497,5601,860,3694,652,5595,3458,9372,4091,5054,2353,4052,2022,10468,7471,7050,4088,1950,6772,4790,4086,7057,4090,100302237,4089,23090,1499,3725,7046,6498,4092,7048,3624,7049,6774,1387	FKBP1A,EP300,BAMBI,ZEB2,LIF,SMAD9,NOG,SPP1,SMAD2,HRAS,JAK1,RUNX3,TGFB1,LEFTY1,LEF1,LEFTY2,TNF,SKI,MAPK9,RUNX2,ITGB6,BMP4,MAPK3,IFNG,ZFYVE9,SMAD6,SERPINE1,FOS,LTBP1,ENG,FST,WNT1,TGIF1,SMAD3,EGF,STAT1,NFKB1,SMAD1,THBS1,SMAD5,MIR1281,SMAD4,ZNF423,CTNNB1,JUN,TGFBR1,SKIL,SMAD7,TGFBR2,INHBA,TGFBR3,STAT3,CREBBP
WP195	IL-1 signaling pathway	0.375613266811304	-0.979195210622986	57	52	0.0110239559041764	4717	5310	1386,5966,51295,11213,5595,5601,3551,4214,10746,23118,5605,3316,10454,207,8878,5599,9261,5609,7334,3556,5606,9020,4793,5608,3553,5335,3552,5295,4792,57161,7335,5970,7189,6347,3725,51135,6416,1432,6885,1147,4790,5296,3656,4615,5604,3554,57162,5594,54472,4215,5590,5781	ATF2,REL,ECSIT,IRAK3,MAPK3,MAPK9,IKBKB,MAP3K1,MAP3K2,TAB2,MAP2K2,HSPB2,TAB1,AKT1,SQSTM1,MAPK8,MAPKAPK2,MAP2K7,UBE2N,IL1RAP,MAP2K3,MAP3K14,NFKBIB,MAP2K6,IL1B,PLCG1,IL1A,PIK3R1,NFKBIA,PELI2,UBE2V1,RELA,TRAF6,CCL2,JUN,IRAK4,MAP2K4,MAPK14,MAP3K7,CHUK,NFKB1,PIK3R2,IRAK2,MYD88,MAP2K1,IL1R1,PELI1,MAPK1,TOLLIP,MAP3K3,PRKCZ,PTPN11
WP2361	Gastric Cancer Network 1	0.38040701324079	-0.966513511990867	28	26	0.00551197795208819	4717	5310	8209,324,1894,6286,3020,9585,4605,8607,4173,22974,7153,11082,64094,54891,57122,11065,144455,55125,56992,54476,121504,8900,286826,6790,86,1063	GATD3,APC,ECT2,S100P,H3-3A,KIF20B,MYBL2,RUVBL1,MCM4,TPX2,TOP2A,ESM1,SMOC2,INO80D,NUP107,UBE2C,E2F7,CEP192,KIF15,RNF216,H4C16,CCNA1,LIN9,AURKA,ACTL6A,CENPF
WP2203	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway	0.384723052181211	-0.955231548530966	47	43	0.00911596353614585	4717	5310	5601,5970,4791,5595,7525,6714,4792,6774,6194,3569,4609,9846,7292,1432,55361,2534,6776,5605,3576,6777,2242,6778,1978,5604,85480,5599,3932,207,4790,6772,5971,3716,3717,1154,5781,2475,3575,5290,6775,6356,3559,5594,4067	MAPK9,RELA,NFKB2,MAPK3,YES1,SRC,NFKBIA,STAT3,RPS6,IL6,MYC,GAB2,TNFSF4,MAPK14,PI4K2A,FYN,STAT5A,MAP2K2,CXCL8,STAT5B,FES,STAT6,EIF4EBP1,MAP2K1,TSLP,MAPK8,LCK,AKT1,NFKB1,STAT1,RELB,JAK1,JAK2,CISH,PTPN11,MTOR,IL7R,PIK3CA,STAT4,CCL11,IL2RA,MAPK1,LYN
WP231	TNF alpha Signaling Pathway	0.385324171980117	-0.953670293838663	94	85	0.0180199279202883	4717	5310	283455,6347,3725,56957,6416,2885,6885,4893,11140,5708,581,1147,3569,1387,330,7128,4792,23291,11035,8717,317,6654,7295,56616,8837,5594,8454,7185,329,4215,5590,10010,7133,8439,29110,842,6610,6500,836,840,4790,4794,23118,7124,55312,5515,1326,4217,117584,5871,2752,10131,7132,5966,5347,5595,4791,5836,4214,5601,3551,100302213,6401,8945,5609,8772,5606,841,1535,9020,4793,5608,124056,5879,5894,8567,10454,8737,3265,598,3320,207,5599,3845,1457	KSR2,CCL2,JUN,OTUD7B,MAP2K4,GRB2,MAP3K7,NRAS,CDC37,PSMD2,BAX,CHUK,IL6,CREBBP,BIRC3,TNFAIP3,NFKBIA,FBXW11,RIPK3,TRADD,APAF1,SOS1,TXN,DIABLO,CFLAR,MAPK1,CUL1,TRAF1,BIRC2,MAP3K3,PRKCZ,TANK,TNFRSF1B,NSMAF,TBK1,CASP9,SMPD2,SKP1,CASP3,CASP7,NFKB1,NFKBIE,TAB2,TNF,RFK,PPP2CA,MAP3K8,MAP3K5,RFFL,MAP4K2,GLUL,TRAP1,TNFRSF1A,REL,PLK1,MAPK3,NFKB2,PYGL,MAP3K1,MAPK9,IKBKB,MIR1181,SELE,BTRC,MAP2K7,FADD,MAP2K3,CASP8,CYBA,MAP3K14,NFKBIB,MAP2K6,NOXO1,RAC1,RAF1,MADD,TAB1,RIPK1,HRAS,BCL2L1,HSP90AA1,AKT1,MAPK8,KRAS,CSNK2A1
WP3879	4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression	0.386719951663243	-0.950054487018587	18	17	0.00360398558405766	4717	5310	5595,207,5604,2872,5894,55872,4296,5606,7248,5562,4217,5608,2475,1977,5594,1978,5605	MAPK3,AKT1,MAP2K1,MKNK2,RAF1,PBK,MAP3K11,MAP2K3,TSC1,PRKAA1,MAP3K5,MAP2K6,MTOR,EIF4E,MAPK1,EIF4EBP1,MAP2K2
WP3664	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds	0.386719951663243	-0.950054487018587	18	17	0.00360398558405766	4717	5310	8658,154141,4035,8324,8321,324,1856,6925,27122,7471,8312,1452,1499,2932,8325,51176,6424	TNKS,MBOAT1,LRP1,FZD7,FZD1,APC,DVL2,TCF4,DKK3,WNT1,AXIN1,CSNK1A1,CTNNB1,GSK3B,FZD8,LEF1,SFRP4
WP3859	TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition	0.386719951663243	-0.950054487018587	18	17	0.00360398558405766	4717	5310	1014,2335,6615,7040,5594,7431,3371,6591,5595,1004,207,4087,1000,4088,860,4089,999	CDH16,FN1,SNAI1,TGFB1,MAPK1,VIM,TNC,SNAI2,MAPK3,CDH6,AKT1,SMAD2,CDH2,SMAD3,RUNX2,SMAD4,CDH1
WP2485	NAD Biosynthesis II (from tryptophan)	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	23475,8564,6999,8942,64802,55191,23498,125061	QPRT,KMO,TDO2,KYNU,NMNAT1,NADSYN1,HAAO,AFMID
WP136	Phase I biotransformations, non P450	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	5444,221223,5446,3988,5445,1066,8824,2098	PON1,CES5A,PON3,LIPA,PON2,CES1,CES2,ESD
WP237	Glucocorticoid & Mineralcorticoid Metabolism	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	1586,3291,1583,3290,1589,3284,1585,3283	CYP17A1,HSD11B2,CYP11A1,HSD11B1,CYP21A2,HSD3B2,CYP11B2,HSD3B1
WP3655	Hypothetical Craniofacial Development Pathway	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	3664,9411,7043,8626,7471,7020,100132526,387	IRF6,ARHGAP29,TGFB3,TP63,WNT1,TFAP2A,FGD5P1,RHOA
WP3634	Insulin signalling in human adipocytes (normal condition)	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	6517,3643,6198,6194,9882,208,2475,3667	SLC2A4,INSR,RPS6KB1,RPS6,TBC1D4,AKT2,MTOR,IRS1
WP3407	FTO Obesity Variant Mechanism	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	7350,10891,63976,6899,10265,79191,84159,79068	UCP1,PPARGC1A,PRDM16,TBX1,IRX5,IRX3,ARID5B,FTO
WP3635	Insulin signalling in human adipocytes (diabetic condition)	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	6517,9882,6194,6198,3643,3667,2475,208	SLC2A4,TBC1D4,RPS6,RPS6KB1,INSR,IRS1,MTOR,AKT2
WP1604	Codeine and Morphine Metabolism	0.38750976969826	-0.948014218382013	8	8	0.00169599321602714	4717	5310	8714,54658,10599,1244,7364,5243,1565,1576	ABCC3,UGT1A1,SLCO1B1,ABCC2,UGT2B7,ABCB1,CYP2D6,CYP3A4
WP3845	Canonical  and Non-canonical Notch signaling	0.405791695768927	-0.90191531565164	27	25	0.0052999788000848	4717	5310	4237,4854,4236,65989,9794,5663,3714,54567,23462,4853,102,10683,5664,27255,1147,51176,3516,55534,84441,182,92737,3280,6237,8788,4855	MFAP2,NOTCH3,MFAP1,DLK2,MAML1,PSEN1,JAG2,DLL4,HEY1,NOTCH2,ADAM10,DLL3,PSEN2,CNTN6,CHUK,LEF1,RBPJ,MAML3,MAML2,JAG1,DNER,HES1,RRAS,DLK1,NOTCH4
WP2012	miRs in Muscle Cell Differentiation	0.417065126665714	-0.874512890323544	36	33	0.00699597201611194	4717	5310	5588,4654,5587,5583,23683,5576,5577,407016,5578,3398,5573,5590,5579,406989,6722,5081,5584,5580,4205,5566,407015,5567,5568,100271849,64100,5575,442890,5581,4208,2146,5582,4617,4209	PRKCQ,MYOD1,PRKD1,PRKCH,PRKD3,PRKAR2A,PRKAR2B,MIR26A2,PRKCA,ID2,PRKAR1A,PRKCZ,PRKCB,MIR206,SRF,PAX7,PRKCI,PRKCD,MEF2A,PRKACA,MIR26A1,PRKACB,PRKACG,MEF2B,ELSPBP1,PRKAR1B,MIR133B,PRKCE,MEF2C,EZH2,PRKCG,MYF5,MEF2D
WP78	TCA Cycle	0.418653323079779	-0.870712092754745	17	16	0.00339198643205427	4717	5310	3420,3419,8801,4967,1738,1743,8802,3418,6390,6391,2271,6389,1431,50,6392,4191	IDH3B,IDH3A,SUCLG2,OGDH,DLD,DLST,SUCLG1,IDH2,SDHB,SDHC,FH,SDHA,CS,ACO2,SDHD,MDH2
WP3678	Amplification and Expansion of Oncogenic Pathways as Metastatic Traits	0.418653323079779	-0.870712092754745	17	16	0.00339198643205427	4717	5310	7472,5294,6932,51176,7428,7412,10631,9595,7852,6934,3371,182,83439,2034,6714,7422	WNT2,PIK3CG,TCF7,LEF1,VHL,VCAM1,POSTN,CYTIP,CXCR4,TCF7L2,TNC,JAG1,TCF7L1,EPAS1,SRC,VEGFA
WP368	Mitochondrial LC-Fatty Acid Beta-Oxidation	0.418653323079779	-0.870712092754745	17	16	0.00339198643205427	4717	5310	3033,80221,6342,35,55825,1376,1632,2181,3030,2180,1374,788,37,1962,34,33	HADH,ACSF2,SCP2,ACADS,PECR,CPT2,ECI1,ACSL3,HADHA,ACSL1,CPT1A,SLC25A20,ACADVL,EHHADH,ACADM,ACADL
WP3286	Copper homeostasis	0.430175133456261	-0.843562866105825	54	49	0.0103879584481662	4717	5310	3725,5728,79689,26872,1318,595,6649,4501,7157,261729,84560,8754,4891,4489,4494,4490,1353,540,6868,55240,836,4137,2932,4520,4495,4504,4500,54739,150684,2309,1317,2308,5621,4493,4502,5290,4498,23621,475,6647,6667,9973,324,207,6341,22823,351,102,4193	JUN,PTEN,STEAP4,STEAP1,SLC31A2,CCND1,SOD3,MT1X,TP53,STEAP2,MT4,ADAM9,SLC11A2,MT1A,MT1F,MT1B,COX11,ATP7B,ADAM17,STEAP3,CASP3,MAPT,GSK3B,MTF1,MT1G,MT3,MT1L,XAF1,COMMD1,FOXO3,SLC31A1,FOXO1,PRNP,MT1E,MT2A,PIK3CA,MT1JP,BACE1,ATOX1,SOD1,SP1,CCS,APC,AKT1,SCO1,MTF2,APP,ADAM10,MDM2
WP530	Cytokines and Inflammatory Response	0.432250976693576	-0.838748894864144	26	24	0.00508797964808141	4717	5310	3586,7124,3122,7040,3569,3600,3552,3574,1435,2919,3596,2920,3458,3456,3593,3567,3562,3558,3553,1437,3123,3565,920,5154	IL10,TNF,HLA-DRA,TGFB1,IL6,IL15,IL1A,IL7,CSF1,CXCL1,IL13,CXCL2,IFNG,IFNB1,IL12B,IL5,IL3,IL2,IL1B,CSF2,HLA-DRB1,IL4,CD4,PDGFA
WP1272	Selenium Micronutrient Network	0.436298154722755	-0.829429428238655	7	7	0.00148399406402374	4717	5310	51734,342184,7296,114112,7295,10587,6415	MSRB1,FMN1,TXNRD1,TXNRD3,TXN,TXNRD2,SELENOW
WP3595	mir-124 predicted interactions with cell cycle and differentiation	0.436298154722755	-0.829429428238655	7	7	0.00148399406402374	4717	5310	51804,55437,58190,5725,6794,100616459,5562	SIX4,STRADB,CTDSP1,PTBP1,STK11,MIR4745,PRKAA1
WP2596	Gastric acid production	0.436298154722755	-0.829429428238655	7	7	0.00148399406402374	4717	5310	6343,4588,885,2922,7432,2694,2520	SCT,MUC6,CCK,GRP,VIP,CBLIF,GAST
WP1310	Selenium Micronutrient Network	0.436298154722755	-0.829429428238655	7	7	0.00148399406402374	4717	5310	51734,114112,342184,7296,7295,6415,10587	MSRB1,TXNRD3,FMN1,TXNRD1,TXN,SELENOW,TXNRD2
WP678	Arachidonate Epoxygenase / Epoxide Hydrolase	0.436298154722755	-0.829429428238655	7	7	0.00148399406402374	4717	5310	9377,1351,2950,2053,1559,1573,1558	COX5A,COX8A,GSTP1,EPHX2,CYP2C9,CYP2J2,CYP2C8
WP438	Non-homologous end joining	0.436298154722755	-0.829429428238655	7	7	0.00148399406402374	4717	5310	4361,7520,5591,79840,10111,7518,2547	MRE11,XRCC5,PRKDC,NHEJ1,RAD50,XRCC4,XRCC6
WP1533	Vitamin B12 Metabolism	0.449195943303047	-0.800296087095745	53	48	0.0101759592961628	4717	5310	326625,4790,6288,6472,84693,3043,1491,19,3383,6289,4143,6649,2694,5054,6648,3630,2155,4036,12,2147,5970,3569,3039,4552,4594,348,6347,338,8029,4548,1401,3553,335,3949,6647,4353,3458,4791,3643,6947,6352,4524,213,5340,5327,875,949,7124	MMAB,NFKB1,SAA1,SHMT2,MCEE,HBB,CTH,ABCA1,ICAM1,SAA2,MAT1A,SOD3,CBLIF,SERPINE1,SOD2,INS,F7,LRP2,SERPINA3,F2,RELA,IL6,HBA1,MTRR,MMUT,APOE,CCL2,APOB,CUBN,MTR,CRP,IL1B,APOA1,LDLR,SOD1,MPO,IFNG,NFKB2,INSR,TCN1,CCL5,MTHFR,ALB,PLG,PLAT,CBS,SCARB1,TNF
WP2453	TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)	0.452485901941456	-0.792998672257996	16	15	0.00317998728005088	4717	5310	48,1431,4190,47,6389,2271,3417,1743,1737,1738,3419,8801,4967,5105,5091	ACO1,CS,MDH1,ACLY,SDHA,FH,IDH1,DLST,DLAT,DLD,IDH3A,SUCLG2,OGDH,PCK1,PC
WP3644	NAD+ metabolism	0.452485901941456	-0.792998672257996	16	15	0.00317998728005088	4717	5310	64802,51548,65220,23408,23410,349565,23411,10135,142,4907,952,22933,23057,51547,23409	NMNAT1,SIRT6,NADK,SIRT5,SIRT3,NMNAT3,SIRT1,NAMPT,PARP1,NT5E,CD38,SIRT2,NMNAT2,SIRT7,SIRT4
WP205	IL-7 Signaling Pathway	0.459744832761026	-0.777083654797353	25	23	0.00487598049607802	4717	5310	6774,5295,595,3574,5595,6777,1027,2534,5605,6776,4609,2932,3718,2185,3716,207,5296,6772,598,5604,3559,5594,3575	STAT3,PIK3R1,CCND1,IL7,MAPK3,STAT5B,CDKN1B,FYN,MAP2K2,STAT5A,MYC,GSK3B,JAK3,PTK2B,JAK1,AKT1,PIK3R2,STAT1,BCL2L1,MAP2K1,IL2RA,MAPK1,IL7R
WP3668	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease	0.459744832761026	-0.777083654797353	25	23	0.00487598049607802	4717	5310	7046,860,5595,2201,7048,1490,84467,7049,4053,6464,10631,1432,2200,4087,4088,5599,285,4089,5054,2022,4052,185,5594	TGFBR1,RUNX2,MAPK3,FBN2,TGFBR2,CCN2,FBN3,TGFBR3,LTBP2,SHC1,POSTN,MAPK14,FBN1,SMAD2,SMAD3,MAPK8,ANGPT2,SMAD4,SERPINE1,ENG,LTBP1,AGTR1,MAPK1
WP364	IL-6 signaling pathway	0.466662617142901	-0.762148729635472	43	39	0.00826796692813229	4717	5310	6654,5595,2063,5295,1387,3569,3570,6774,6464,2932,7409,2885,7432,9021,3065,6885,5605,6416,6198,3572,5604,5580,8648,598,2549,5296,6772,207,7297,3716,3659,5879,1401,3717,3726,5781,639,183,5594	SOS1,MAPK3,NR2F6,PIK3R1,CREBBP,IL6,IL6R,STAT3,SHC1,GSK3B,VAV1,GRB2,VIP,SOCS3,HDAC1,MAP3K7,MAP2K2,MAP2K4,RPS6KB1,IL6ST,MAP2K1,PRKCD,NCOA1,BCL2L1,GAB1,PIK3R2,STAT1,AKT1,TYK2,JAK1,IRF1,RAC1,CRP,JAK2,JUNB,PTPN11,PRDM1,AGT,MAPK1
WP176	Folate Metabolism	0.488117302659846	-0.717199527711302	69	62	0.0131439474242103	4717	5310	3565,6289,3383,19,1491,6472,3043,257202,6288,4790,2878,3630,6648,7157,2876,5054,847,2879,4143,6649,4552,80308,3039,6470,3569,2147,390243,5970,12,2155,1719,4548,6347,338,1401,191,2350,2877,2618,6647,4522,3949,335,3558,3553,2352,3643,10797,4791,1435,4353,3458,55312,7124,5327,875,949,2348,10588,5340,4524,213	IL4,SAA2,ICAM1,ABCA1,CTH,SHMT2,HBB,GPX6,SAA1,NFKB1,GPX3,INS,SOD2,TP53,GPX1,SERPINE1,CAT,GPX4,MAT1A,SOD3,MTRR,FLAD1,HBA1,SHMT1,IL6,F2,IZUMO1R,RELA,SERPINA3,F7,DHFR,MTR,CCL2,APOB,CRP,AHCY,FOLR2,GPX2,GART,SOD1,MTHFD1,LDLR,APOA1,IL2,IL1B,FOLR3,INSR,MTHFD2,NFKB2,CSF1,MPO,IFNG,RFK,TNF,PLAT,CBS,SCARB1,FOLR1,MTHFS,PLG,MTHFR,ALB
WP206	Fatty Acid Omega Oxidation	0.488189775634472	-0.717051064228098	15	14	0.00296798812804749	4717	5310	1565,125,130,216,1544,127,124,126,1576,131,1543,1548,217,1579	CYP2D6,ADH1B,ADH6,ALDH1A1,CYP1A2,ADH4,ADH1A,ADH1C,CYP3A4,ADH7,CYP1A1,CYP2A6,ALDH2,CYP4A11
WP334	GPCRs, Class B Secretin-like	0.488217809747057	-0.716993641256356	24	22	0.00466398134407462	4717	5310	23266,22859,2740,6344,23284,1394,2642,5746,976,2692,30817,64123,5745,7433,2696,9340,117,1395,10203,7434,2015,799	ADGRL2,ADGRL1,GLP1R,SCTR,ADGRL3,CRHR1,GCGR,PTH2R,ADGRE5,GHRHR,ADGRE2,ADGRL4,PTH1R,VIPR1,GIPR,GLP2R,ADCYAP1R1,CRHR2,CALCRL,VIPR2,ADGRE1,CALCR
WP304	Kit receptor signaling pathway	0.488233936604762	-0.716960609705608	60	54	0.0114479542081832	4717	5310	4254,5894,3265,207,5599,2887,4067,596,2033,6194,6714,5777,5595,3635,2309,5605,6776,867,4137,4286,9846,6615,3717,100302237,5296,6772,5604,9306,3815,10603,5594,8651,5579,5578,6195,5781,3726,2353,5335,6774,5295,6654,6591,6777,6198,4145,2534,6909,2885,1432,1796,7409,1398,6464	KITLG,RAF1,HRAS,AKT1,MAPK8,GRB10,LYN,BCL2,EP300,RPS6,SRC,PTPN6,MAPK3,INPP5D,FOXO3,MAP2K2,STAT5A,CBL,MAPT,MITF,GAB2,SNAI1,JAK2,MIR1281,PIK3R2,STAT1,MAP2K1,SOCS6,KIT,SH2B2,MAPK1,SOCS1,PRKCB,PRKCA,RPS6KA1,PTPN11,JUNB,FOS,PLCG1,STAT3,PIK3R1,SOS1,SNAI2,STAT5B,RPS6KB1,MATK,FYN,TBX2,GRB2,MAPK14,DOK1,VAV1,CRK,SHC1
WP2636	Common Pathways Underlying Drug Addiction	0.488353216426594	-0.716716330796029	42	38	0.0080559677761289	4717	5310	5582,2770,5595,815,1815,5906,5908,72,2778,2903,5502,5605,5499,1812,5501,805,2891,1813,5567,5568,5894,814,5566,1385,114,71,2893,60,5604,2915,5594,801,2911,5579,5500,2890,5578,107	PRKCG,GNAI1,MAPK3,CAMK2A,DRD4,RAP1A,RAP1B,ACTG2,GNAS,GRIN2A,PPP1R1A,MAP2K2,PPP1CA,DRD1,PPP1CC,CALM2,GRIA2,DRD2,PRKACB,PRKACG,RAF1,CAMK4,PRKACA,CREB1,ADCY8,ACTG1,GRIA4,ACTB,MAP2K1,GRM5,MAPK1,CALM1,GRM1,PRKCB,PPP1CB,GRIA1,PRKCA,ADCY1
WP694	Arylamine metabolism	0.491217451207589	-0.710868375077553	6	6	0.00127199491202035	4717	5310	10,6817,54657,6799,54600,1544	NAT2,SULT1A1,UGT1A4,SULT1A2,UGT1A9,CYP1A2
WP1600	Nicotine Metabolism	0.491217451207589	-0.710868375077553	6	6	0.00127199491202035	4717	5310	316,2328,54657,1555,54600,1548	AOX1,FMO3,UGT1A4,CYP2B6,UGT1A9,CYP2A6
WP1981	Thyroxine (Thyroid Hormone) Production	0.491217451207589	-0.710868375077553	6	6	0.00127199491202035	4717	5310	7253,7173,1081,7038,6528,7200	TSHR,TPO,CGA,TG,SLC5A5,TRH
WP254	Apoptosis	0.503162158721576	-0.686842777692392	86	77	0.0163239347042612	4717	5310	5295,5602,4792,54205,330,5970,8837,56616,3664,317,332,8743,8717,3660,3481,27113,6416,5366,3725,581,1147,10018,843,1676,3662,8739,836,842,4049,3659,3479,4794,4790,8738,840,7185,329,9169,7161,7157,837,7133,834,356,578,7132,3002,3551,4214,8718,355,835,7124,1029,7187,4609,3663,4193,27242,839,5551,1677,3661,665,598,8737,207,4170,8772,596,8626,3665,3480,8795,4793,3070,841	PIK3R1,MAPK10,NFKBIA,CYCS,BIRC3,RELA,CFLAR,DIABLO,IRF6,APAF1,BIRC5,TNFSF10,TRADD,IRF2,IGF2,BBC3,MAP2K4,PMAIP1,JUN,BAX,CHUK,BCL2L11,CASP10,DFFA,IRF4,HRK,CASP3,CASP9,LTA,IRF1,IGF1,NFKBIE,NFKB1,CRADD,CASP7,TRAF1,BIRC2,SCAF11,TP73,TP53,CASP4,TNFRSF1B,CASP1,FASLG,BAK1,TNFRSF1A,GZMB,IKBKB,MAP3K1,TNFRSF25,FAS,CASP2,TNF,CDKN2A,TRAF3,MYC,IRF5,MDM2,TNFRSF21,CASP6,PRF1,DFFB,IRF3,BNIP3L,BCL2L1,RIPK1,AKT1,MCL1,FADD,BCL2,TP63,IRF7,IGF1R,TNFRSF10B,NFKBIB,HELLS,CASP8
WP2637	Structural Pathway of Interleukin 1 (IL-1)	0.508348613948541	-0.676587818833897	50	45	0.00953996184015264	4717	5310	1386,5595,3551,2872,5601,4214,1977,9252,23118,5605,4609,1326,10454,9261,5599,5609,3665,5606,3556,4155,5608,4793,9020,5602,3552,4792,5970,7189,51135,6416,6885,1432,1147,6294,3656,4790,4615,5600,3554,5604,54472,5594,4215,2353,10010	ATF2,MAPK3,IKBKB,MKNK2,MAPK9,MAP3K1,EIF4E,RPS6KA5,TAB2,MAP2K2,MYC,MAP3K8,TAB1,MAPKAPK2,MAPK8,MAP2K7,IRF7,MAP2K3,IL1RAP,MBP,MAP2K6,NFKBIB,MAP3K14,MAPK10,IL1A,NFKBIA,RELA,TRAF6,IRAK4,MAP2K4,MAP3K7,MAPK14,CHUK,SAFB,IRAK2,NFKB1,MYD88,MAPK11,IL1R1,MAP2K1,TOLLIP,MAPK1,MAP3K3,FOS,TANK
WP2525	Trans-sulfuration and one carbon metabolism	0.513286452438525	-0.666921202831541	32	29	0.00614797540809837	4717	5310	4524,200895,875,4548,441024,5723,25902,23382,1719,635,275,10797,27430,6470,1786,2729,1788,29947,4143,10768,4522,4144,29968,1491,6472,2730,191,7298,2937	MTHFR,DHFR2,CBS,MTR,MTHFD2L,PSPH,MTHFD1L,AHCYL2,DHFR,BHMT,AMT,MTHFD2,MAT2B,SHMT1,DNMT1,GCLC,DNMT3A,DNMT3L,MAT1A,AHCYL1,MTHFD1,MAT2A,PSAT1,CTH,SHMT2,GCLM,AHCY,TYMS,GSS
WP185	Integrin-mediated Cell Adhesion	0.515523404997442	-0.662572574038925	103	92	0.0195039219843121	4717	5310	5829,8516,5608,53358,10580,5058,1445,5062,5894,5596,5879,998,10000,84665,11131,859,8515,3694,56924,3689,5747,5906,3690,3679,6714,3673,5170,9564,3683,3688,2889,5607,8874,3695,5594,9815,22801,3691,825,10298,5296,3696,6300,7408,3655,3687,5606,3681,3675,208,7791,3685,207,3265,823,5598,5881,5605,10753,726,85366,6010,5908,824,673,3676,6414,5880,3672,3682,7145,3611,10451,5604,5597,23473,6464,1398,3693,2885,1793,9475,3680,7410,3674,2534,3684,7414,858,857,6654,5602	PXN,ITGA8,MAP2K6,SHC3,SORBS1,PAK1,CSK,PAK2,RAF1,MAPK4,RAC1,CDC42,AKT3,MYPN,CAPN11,CAV3,ITGA10,ITGB6,PAK6,ITGB2,PTK2,RAP1A,ITGB3,ITGA7,SRC,ITGA2,PDPK1,BCAR1,ITGAL,ITGB1,RAPGEF1,MAP2K5,ARHGEF7,ITGB7,MAPK1,GIT2,ITGA11,ITGB4,CAPN3,PAK4,PIK3R2,ITGB8,MAPK12,VASP,ITGA6,ITGAX,MAP2K3,ITGAD,ITGA3,AKT2,ZYX,ITGAV,AKT1,HRAS,CAPN1,MAPK7,RAC3,MAP2K2,CAPN9,CAPN5,MYLK2,RHO,RAP1B,CAPN2,BRAF,ITGA4,SELENOP,RAC2,ITGA1,ITGAE,TNS1,ILK,VAV3,MAP2K1,MAPK6,CAPN7,SHC1,CRK,ITGB5,GRB2,DOCK1,ROCK2,ITGA9,VAV2,ITGA2B,FYN,ITGAM,VCL,CAV2,CAV1,SOS1,MAPK10
WP712	Estrogen signaling pathway	0.517597241180864	-0.658557865831165	23	21	0.00445198219207123	4717	5310	596,3725,5594,2792,2778,2353,1147,1432,5290,5566,2852,673,5604,2782,5601,3551,6667,4790,1385,2099,207	BCL2,JUN,MAPK1,GNGT1,GNAS,FOS,CHUK,MAPK14,PIK3CA,PRKACA,GPER1,BRAF,MAP2K1,GNB1,MAPK9,IKBKB,SP1,NFKB1,CREB1,ESR1,AKT1
WP3853	ERK Pathway in Huntington's Disease	0.525700095311185	-0.643024389853375	14	13	0.0027559889760441	4717	5310	627,4915,1956,5594,5609,9252,2911,840,1385,3265,1950,5894,836	BDNF,NTRK2,EGFR,MAPK1,MAP2K7,RPS6KA5,GRM1,CASP7,CREB1,HRAS,EGF,RAF1,CASP3
WP1544	MicroRNAs in cardiomyocyte hypertrophy	0.529668905855721	-0.635503173578627	102	91	0.0192919228323087	4717	5310	2626,4790,8503,1950,5293,5604,3479,406990,442890,4041,1147,9475,6416,207,2535,5599,3572,208,1154,4638,5598,5532,5606,51564,4040,406976,5330,9020,5530,1489,4879,4878,5320,805,7040,5605,7474,7124,5296,1022,817,4776,8321,406896,5607,5594,8893,2263,183,406911,5579,406961,89780,1906,6774,5295,5592,1432,5291,406912,1499,407034,2247,406932,9641,10014,5879,5894,5596,406895,1855,10454,1827,5290,5294,3084,2475,5608,91807,3976,801,3480,5609,387,5595,9734,3551,5170,2932,9759,50804	GATA4,NFKB1,PIK3R3,EGF,PIK3CD,MAP2K1,IGF1,MIR208A,MIR133B,LRP5,CHUK,ROCK2,MAP2K4,AKT1,FZD2,MAPK8,IL6ST,AKT2,CISH,MYLK,MAPK7,PPP3CB,MAP2K3,HDAC7,LRP6,MIR199A1,PLCB2,MAP3K14,PPP3CA,CTF1,NPPB,NPPA,PLA2G2A,CALM2,TGFB1,MAP2K2,WNT5A,TNF,PIK3R2,CDK7,CAMK2D,NFATC4,FZD1,MIR103A2,MAP2K5,MAPK1,EIF2B5,FGFR2,AGT,MIR125B1,PRKCB,MIR185,WNT3A,EDN1,STAT3,PIK3R1,PRKG1,MAPK14,PIK3CB,MIR125B2,CTNNB1,MIR30E,FGF2,MIR140,IKBKE,HDAC5,RAC1,RAF1,MAPK4,MIR103A1,DVL1,TAB1,RCAN1,PIK3CA,PIK3CG,NRG1,MTOR,MAP2K6,MYLK3,LIF,CALM1,IGF1R,MAP2K7,RHOA,MAPK3,HDAC9,IKBKB,PDPK1,GSK3B,HDAC4,MYEF2
WP2516	ATM Signaling Pathway	0.53288322888125	-0.62945296159282	40	36	0.00763196947212211	4717	5310	4683,1386,4792,11200,1017,2177,4361,983,472,5601,9874,3725,25,55367,1026,835,8120,4193,1647,5888,1385,8738,8737,5883,898,1111,891,7161,7158,7157,995,9656,10111,4194,672,993	NBN,ATF2,NFKBIA,CHEK2,CDK2,FANCD2,MRE11,CDK1,ATM,MAPK9,TLK1,JUN,ABL1,PIDD1,CDKN1A,CASP2,AP3B2,MDM2,GADD45A,RAD51,CREB1,CRADD,RIPK1,RAD9A,CCNE1,CHEK1,CCNB1,TP73,TP53BP1,TP53,CDC25C,MDC1,RAD50,MDM4,BRCA1,CDC25A
WP524	G13 Signaling Pathway	0.53288322888125	-0.62945296159282	40	36	0.00763196947212211	4717	5310	5879,3984,5296,5293,10672,8826,100302274,801,5305,5216,387,1072,5500,5290,10788,10188,397,57630,5602,9138,1073,85415,6242,4608,23191,6198,1729,5585,9475,8976,4216,4632,998,11113,5291,805	RAC1,LIMK1,PIK3R2,PIK3CD,GNA13,IQGAP1,MIR1178,CALM1,PIP4K2A,PFN1,RHOA,CFL1,PPP1CB,PIK3CA,IQGAP2,TNK2,ARHGDIB,SH3RF1,MAPK10,ARHGEF1,CFL2,RHPN2,RTKN,MYBPH,CYFIP1,RPS6KB1,DIAPH1,PKN1,ROCK2,WASL,MAP3K4,MYL1,CDC42,CIT,PIK3CB,CALM2
WP3651	Pathways Affected in Adenoid Cystic Carcinoma	0.540242537217753	-0.615737097262502	66	59	0.0125079499682001	4717	5310	4609,26292,7994,9223,55534,23135,55914,8332,5605,5591,4603,2309,29128,9863,11200,5290,2033,8289,672,1050,207,3265,3645,54756,2264,23220,5894,5728,2064,221037,10847,4781,6595,23774,23269,472,9874,6605,64324,55783,284058,1387,4613,1487,3008,51742,4149,7157,29072,1111,9611,55294,4602,93986,84159,58508,10933,100302237,27255	MYC,MYCBP,KAT6A,MAGI1,MAML3,KDM6B,ERBIN,H2AC16,MAP2K2,PRKDC,MYBL1,FOXO3,UHRF1,MAGI2,CHEK2,PIK3CA,EP300,ARID1A,BRCA1,CEBPA,AKT1,HRAS,INSRR,IL17RD,FGFR4,DTX4,RAF1,PTEN,ERBB2,JMJD1C,SRCAP,NFIB,SMARCA2,BRD1,MGA,ATM,TLK1,SMARCE1,NSD1,CMTR2,KANSL1,CREBBP,MYCN,CTBP1,H1-4,ARID4B,MAX,TP53,SETD2,CHEK1,NCOR1,FBXW7,MYB,FOXP2,ARID5B,KMT2C,MORF4L1,MIR1281,CNTN6
WP357	Fatty Acid Biosynthesis	0.547791445930591	-0.601860637589809	22	20	0.00423998304006784	4717	5310	1666,6319,2181,2180,10449,51102,55268,47,51703,1891,3033,31,79746,5091,55902,32,2194,23305,55862,55825	DECR1,SCD,ACSL3,ACSL1,ACAA2,MECR,ECHDC2,ACLY,ACSL5,ECH1,HADH,ACACA,ECHDC3,PC,ACSS2,ACACB,FASN,ACSL6,ECHDC1,PECR
WP100	Glutathione metabolism	0.547791445930591	-0.601860637589809	22	20	0.00423998304006784	4717	5310	2936,2946,2729,290,2730,2938,3417,2937,91227,2953,2952,2876,2678,221357,2878,2877,2944,2687,2879,92086	GSR,GSTM2,GCLC,ANPEP,GCLM,GSTA1,IDH1,GSS,GGTLC2,GSTT2,GSTT1,GPX1,GGT1,GSTA5,GPX3,GPX2,GSTM1,GGT5,GPX4,GGTLC1
WP2849	Hematopoietic Stem Cell Differentiation	0.549151928103314	-0.599380139685359	48	43	0.00911596353614585	4717	5310	10320,3690,1435,3567,6776,2815,406942,2993,8780,4601,4254,100506403,406915,406995,7852,3562,2624,863,3553,3569,3552,28,3757,406919,91,2313,100422842,3674,4005,3071,7173,7409,10661,861,1437,4778,4773,4602,23650,2056,4066,6688,2353	IKZF1,ITGB3,CSF1,IL5,STAT5A,GP9,MIR150,GYPA,RIOK3,MXI1,KITLG,LOC100506403,MIR128-1,MIR181A1,CXCR4,IL3,GATA2,CBFA2T3,IL1B,IL6,IL1A,ABO,KCNH2,MIR130A,ACVR1B,FLI1,MIR3074,ITGA2B,LMO2,NCKAP1L,TPO,VAV1,KLF1,RUNX1,CSF2,NFE2,NFATC2,MYB,TRIM29,EPO,LYL1,SPI1,FOS
WP2542	Sulindac Metabolic Pathway	0.553036625348007	-0.592331049367203	5	5	0.00105999576001696	4717	5310	1544,253827,4482,1545,22921	CYP1A2,MSRB3,MSRA,CYP1B1,MSRB2
WP688	Catalytic cycle of mammalian Flavin-containing MonoOxygenases (FMOs)	0.553036625348007	-0.592331049367203	5	5	0.00105999576001696	4717	5310	2330,2329,2326,2327,2328	FMO5,FMO4,FMO1,FMO2,FMO3
WP2868	TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer	0.553036625348007	-0.592331049367203	5	5	0.00105999576001696	4717	5310	3716,1956,5594,5595,6774	JAK1,EGFR,MAPK1,MAPK3,STAT3
WP2597	Secretion of Hydrochloric Acid in Parietal Cells	0.553036625348007	-0.592331049367203	5	5	0.00105999576001696	4717	5310	1128,887,3274,495,2520	CHRM1,CCKBR,HRH2,ATP4A,GAST
WP186	Homologous recombination	0.564906266389968	-0.571095461793403	13	12	0.0025439898240407	4717	5310	5424,4683,6117,675,472,4361,5888,25788,10111,5893,57804,10714	POLD1,NBN,RPA1,BRCA2,ATM,MRE11,RAD51,RAD54B,RAD50,RAD52,POLD4,POLD3
WP3871	Valproic acid pathway	0.564906266389968	-0.571095461793403	13	12	0.0025439898240407	4717	5310	116285,3065,3030,3712,54659,1962,1555,18,36,1559,1548,3032	ACSM1,HDAC1,HADHA,IVD,UGT1A3,EHHADH,CYP2B6,ABAT,ACADSB,CYP2C9,CYP2A6,HADHB
WP1423	Ganglio Sphingolipid Metabolism	0.564906266389968	-0.571095461793403	13	12	0.0025439898240407	4717	5310	29906,127550,2583,6482,8705,6483,51046,9197,8708,30815,8869,6489	ST8SIA5,A3GALT2,B4GALNT1,ST3GAL1,B3GALT4,ST3GAL2,ST8SIA3,SLC33A1,B3GALT1,ST6GALNAC6,ST3GAL5,ST8SIA1
WP2533	Glycerophospholipid Biosynthetic Pathway	0.578687950189795	-0.546991892824426	21	19	0.00402798388806445	4717	5310	114971,56994,2819,54675,10390,9791,23175,55361,9489,5833,10400,8540,8443,8760,9663,10423,346606,8394,5320	PTPMT1,CHPT1,GPD1,CRLS1,CEPT1,PTDSS1,LPIN1,PI4K2A,PGS1,PCYT2,PEMT,AGPS,GNPAT,CDS2,LPIN2,CDIPT,MOGAT3,PIP5K1A,PLA2G2A
WP2507	Nanomaterial induced apoptosis	0.578687950189795	-0.546991892824426	21	19	0.00402798388806445	4717	5310	840,355,4170,317,598,27429,56616,8837,842,5551,54205,839,836,841,578,356,581,2021,8772	CASP7,FAS,MCL1,APAF1,BCL2L1,HTRA2,DIABLO,CFLAR,CASP9,PRF1,CYCS,CASP6,CASP3,CASP8,BAK1,FASLG,BAX,ENDOG,FADD
WP3670	Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway	0.578687950189795	-0.546991892824426	21	19	0.00402798388806445	4717	5310	100302213,100616237,4899,4780,308,11140,2335,1728,2252,5310,7040,84171,650,51295,780,54536,1280,3490,23411	MIR1181,MIR4640,NRF1,NFE2L2,ANXA5,CDC37,FN1,NQO1,FGF7,PKD1,TGFB1,LOXL4,BMP2,ECSIT,DDR1,EXOC6,COL2A1,IGFBP7,SIRT1
WP1591	Heart Development	0.59063403039673	-0.526558691290412	46	41	0.00869196523213907	4717	5310	1482,57057,5781,5594,2296,6722,9464,2626,3170,4086,23493,2255,23462,2065,6899,4776,4089,7422,150572,4773,7423,27302,6909,5308,4772,9421,6910,3670,50805,1499,657,8553,652,7424,4775,4208,659,6469,2303,650,2253	NKX2-5,TBX20,PTPN11,MAPK1,FOXC1,SRF,HAND2,GATA4,FOXA2,SMAD1,HEY2,FGF10,HEY1,ERBB3,TBX1,NFATC4,SMAD4,VEGFA,SMYD1,NFATC2,VEGFB,BMP10,TBX2,PITX2,NFATC1,HAND1,TBX5,ISL1,IRX4,CTNNB1,BMPR1A,BHLHE40,BMP4,VEGFC,NFATC3,MEF2C,BMPR2,SHH,FOXC2,BMP2,FGF8
WP465	Tryptophan metabolism	0.59063403039673	-0.526558691290412	46	41	0.00869196523213907	4717	5310	217,223,847,51366,1576,1543,1644,1588,9420,1573,38,7453,4967,23498,216,1544,4193,8942,7337,1545,224,51166,3276,64320,130013,2639,11185,1553,6999,8854,316,1562,3033,3620,66002,125061,1572,1718,7166,15,26	ALDH2,ALDH9A1,CAT,UBR5,CYP3A4,CYP1A1,DDC,CYP19A1,CYP7B1,CYP2J2,ACAT1,WARS1,OGDH,HAAO,ALDH1A1,CYP1A2,MDM2,KYNU,UBE3A,CYP1B1,ALDH3A2,AADAT,PRMT1,RNF25,ACMSD,GCDH,INMT,CYP2A13,TDO2,ALDH1A2,AOX1,CYP2C18,HADH,IDO1,CYP4F12,AFMID,CYP2F1,DHCR24,TPH1,AANAT,AOC1
WP3613	Photodynamic therapy-induced unfolded protein response	0.590866312250301	-0.526165493170735	29	26	0.00551197795208819	4717	5310	9695,2081,7453,811,9451,51726,3309,467,468,4189,4780,7324,121506,7494,22926,57761,440,4677,23645,10130,5611,10018,83939,100500842,6783,27113	EDEM1,ERN1,WARS1,CALR,EIF2AK3,DNAJB11,HSPA5,ATF3,ATF4,DNAJB9,NFE2L2,UBE2E1,ERP27,XBP1,ATF6,TRIB3,ASNS,NARS1,PPP1R15A,PDIA6,DNAJC3,BCL2L11,EIF2A,MIR3652,SULT1E1,BBC3
WP3529	Zinc homeostasis	0.601700850980616	-0.50799488246297	37	33	0.00699597201611194	4717	5310	4489,221074,55532,4494,91252,55676,4490,64116,201266,25800,4502,4493,7782,10463,4501,84560,64924,4499,7781,283375,7779,23516,57181,55334,29985,4520,169026,7780,4495,4504,29986,148867,4500	MT1A,SLC39A12,SLC30A10,MT1F,SLC39A13,SLC30A6,MT1B,SLC39A8,SLC39A11,SLC39A6,MT2A,MT1E,SLC30A4,SLC30A9,MT1X,MT4,SLC30A5,MT1M,SLC30A3,SLC39A5,SLC30A1,SLC39A14,SLC39A10,SLC39A9,SLC39A3,MTF1,SLC30A8,SLC30A2,MT1G,MT3,SLC39A2,SLC30A7,MT1L
WP619	Type II interferon signaling (IFNG)	0.601700850980616	-0.50799488246297	37	33	0.00699597201611194	4717	5310	4261,5698,3440,8651,6688,6890,9636,5610,5781,3553,3717,3659,3662,3716,3383,10379,6772,5580,3394,3460,3106,6773,4938,2633,3627,9021,8370,2537,3459,3433,3660,3458,3456	CIITA,PSMB9,IFNA2,SOCS1,SPI1,TAP1,ISG15,EIF2AK2,PTPN11,IL1B,JAK2,IRF1,IRF4,JAK1,ICAM1,IRF9,STAT1,PRKCD,IRF8,IFNGR2,HLA-B,STAT2,OAS1,GBP1,CXCL10,SOCS3,H4C14,IFI6,IFNGR1,IFIT2,IRF2,IFNG,IFNB1
WP3614	Photodynamic therapy-induced HIF-1 survival signaling	0.601700850980616	-0.50799488246297	37	33	0.00699597201611194	4717	5310	664,1906,3091,5211,284,7043,332,6515,5743,3485,5366,54583,581,3939,55662,7422,3486,5315,6513,7039,598,285,4170,597,665,3098,7157,2056,3484,405,578,5054,6566	BNIP3,EDN1,HIF1A,PFKL,ANGPT1,TGFB3,BIRC5,SLC2A3,PTGS2,IGFBP2,PMAIP1,EGLN1,BAX,LDHA,HIF1AN,VEGFA,IGFBP3,PKM,SLC2A1,TGFA,BCL2L1,ANGPT2,MCL1,BCL2A1,BNIP3L,HK1,TP53,EPO,IGFBP1,ARNT,BAK1,SERPINE1,SLC16A1
WP1559	TFs Regulate miRNAs related to cardiac hypertrophy	0.605641515322846	-0.501467026825999	12	11	0.00233199067203731	4717	5310	4790,207,208,5534,442890,6774,5923,7040,406912,50804,406911	NFKB1,AKT1,AKT2,PPP3R1,MIR133B,STAT3,RASGRF1,TGFB1,MIR125B2,MYEF2,MIR125B1
WP3849	MAPK  and NFkB Signalling Pathways Inhibited by Yersinia YopJ	0.605641515322846	-0.501467026825999	12	11	0.00233199067203731	4717	5310	4792,5894,7189,5594,3551,5608,1147,9020,4214,6237,4790	NFKBIA,RAF1,TRAF6,MAPK1,IKBKB,MAP2K6,CHUK,MAP3K14,MAP3K1,RRAS,NFKB1
WP106	Alanine and aspartate metabolism	0.605641515322846	-0.501467026825999	12	11	0.00233199067203731	4717	5310	2572,445,435,2571,443,18,189,2805,1615,5091,2806	GAD2,ASS1,ASL,GAD1,ASPA,ABAT,AGXT,GOT1,DARS1,PC,GOT2
WP3672	LncRNA-mediated mechanisms of therapeutic resistance	0.605641515322846	-0.501467026825999	12	11	0.00233199067203731	4717	5310	100885779,55384,401491,7157,5243,1026,598,7475,3091,652995,100124700	LINC-ROR,MEG3,VLDLR-AS1,TP53,ABCB1,CDKN1A,BCL2L1,WNT6,HIF1A,UCA1,HOTAIR
WP2446	Retinoblastoma (RB) in Cancer	0.60639234864407	-0.500228062404967	88	78	0.0165359338562646	4717	5310	5877,4998,891,1111,7298,8819,81620,3146,6596,4173,3148,9126,7465,79027,1869,7157,8317,6118,5984,6502,1719,1019,9133,1633,7272,595,6119,7029,5947,6241,3065,1871,4175,6595,1027,5557,25942,898,5925,2956,4193,5111,5894,1021,11124,10733,6240,890,5603,993,10714,5985,8030,896,7153,1870,580,983,8318,6117,1017,3015,5928,4172,2189,3925,1786,5983,4609,4863,994,1026,9134,5427,10592,7027,25,5591	RABIF,ORC1,CCNB1,CHEK1,TYMS,SAP30,CDT1,HMGB1,HLTF,MCM4,HMGB2,SMC3,WEE1,ZNF655,E2F1,TP53,CDC7,RPA2,RFC4,SKP2,DHFR,CDK4,CCNB2,DCK,TTK,CCND1,RPA3,TFDP2,RBP1,RRM2,HDAC1,E2F3,MCM6,SMARCA2,CDKN1B,PRIM1,SIN3A,CCNE1,RB1,MSH6,MDM2,PCNA,RAF1,CDK6,FAF1,PLK4,RRM1,CCNA2,MAPK13,CDC25A,POLD3,RFC5,CCDC6,CCND3,TOP2A,E2F2,BARD1,CDK1,CDC45,RPA1,CDK2,H2AZ1,RBBP4,MCM3,FANCG,STMN1,DNMT1,RFC3,MYC,NPAT,CDC25B,CDKN1A,CCNE2,POLE2,SMC2,TFDP1,ABL1,PRKDC
WP497	Urea cycle and metabolism of amino groups	0.61015179365398	-0.494047510715124	20	18	0.00381598473606106	4717	5310	1373,65263,1152,4942,2628,6723,5832,384,383,1158,2746,162417,2593,5831,95,435,445,4953	CPS1,PYCR3,CKB,OAT,GATM,SRM,ALDH18A1,ARG2,ARG1,CKM,GLUD1,NAGS,GAMT,PYCR1,ACY1,ASL,ASS1,ODC1
WP732	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling	0.61015179365398	-0.494047510715124	20	18	0.00381598473606106	4717	5310	3708,5594,2776,6722,5605,10125,4893,2005,5923,5894,5595,3265,3357,2626,3356,5604,3845,9261	ITPR1,MAPK1,GNAQ,SRF,MAP2K2,RASGRP1,NRAS,ELK4,RASGRF1,RAF1,MAPK3,HRAS,HTR2B,GATA4,HTR2A,MAP2K1,KRAS,MAPKAPK2
WP1603	Nicotine Activity on Chromaffin Cells	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	1143,775,8913,1136	CHRNB4,CACNA1C,CACNA1G,CHRNA3
WP2491	Diclofenac Metabolic Pathway	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	1555,1562,1557,1558	CYP2B6,CYP2C18,CYP2C19,CYP2C8
WP2253	Pilocytic astrocytoma	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	5781,4763,6654,2885	PTPN11,NF1,SOS1,GRB2
WP690	Polyol Pathway	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	231,3795,229,6652	AKR1B1,KHK,ALDOB,SORD
WP3633	Caffeine and Theobromine metabolism	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	1548,7498,10,1544	CYP2A6,XDH,NAT2,CYP1A2
WP897	Androgen receptor signaling pathway	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	8611,354,90427,1026	PLPP1,KLK3,BMF,CDKN1A
WP1941	Peroxisomal beta-oxidation of tetracosanoyl-CoA	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	30,3295,6342,51	ACAA1,HSD17B4,SCP2,ACOX1
WP3302	eIF5A regulation in response to inhibition of the nuclear export system	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	10642,1984,7514,64328	IGF2BP1,EIF5A,XPO1,XPO4
WP1133	Androgen receptor signaling pathway	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	1026,90427,354,8611	CDKN1A,BMF,KLK3,PLPP1
WP733	Serotonin Receptor 2 and STAT3 Signaling	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	2776,3356,3717,6774	GNAQ,HTR2A,JAK2,STAT3
WP2889	Oxytocin signaling	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	5021,5333,952,2776	OXTR,PLCD1,CD38,GNAQ
WP521	Amino acid conjugation of benzoic acid	0.622620906875481	-0.473817441590654	4	4	0.000847996608013568	4717	5310	92292,55902,219970,10249	GLYATL1,ACSS2,GLYATL2,GLYAT
WP466	DNA Replication	0.673913512460562	-0.394653496094969	42	37	0.0078439686241255	4717	5310	81620,10926,4999,5001,5982,5111,55388,5981,4998,4174,7311,23595,23594,5985,10714,4173,6119,5424,7316,5000,4172,990,1017,5984,6117,6118,8318,4171,8317,5558,5557,5427,4175,57804,51053,5983,23649	CDT1,DBF4,ORC2,ORC5,RFC2,PCNA,MCM10,RFC1,ORC1,MCM5,UBA52,ORC3,ORC6,RFC5,POLD3,MCM4,RPA3,POLD1,UBC,ORC4,MCM3,CDC6,CDK2,RFC4,RPA1,RPA2,CDC45,MCM2,CDC7,PRIM2,PRIM1,POLE2,MCM6,POLD4,GMNN,RFC3,POLA2
WP2333	Trans-sulfuration pathway	0.69067510915498	-0.370085740665591	10	9	0.00190799236803053	4717	5310	191,2730,51380,1786,27430,4548,875,2805,1491	AHCY,GCLM,CSAD,DNMT1,MAT2B,MTR,CBS,GOT1,CTH
WP2113	Type III interferon signaling	0.69067510915498	-0.370085740665591	10	9	0.00190799236803053	4717	5310	10379,6772,282618,282616,7297,3716,163702,6773,3588	IRF9,STAT1,IFNL1,IFNL2,TYK2,JAK1,IFNLR1,STAT2,IL10RB
WP1531	Vitamin D Metabolism	0.69067510915498	-0.370085740665591	10	9	0.00190799236803053	4717	5310	2638,1717,6256,120227,5741,7421,1593,1591,1594	GC,DHCR7,RXRA,CYP2R1,PTH,VDR,CYP27A1,CYP24A1,CYP27B1
WP453	Inflammatory Response Pathway	0.694271748119049	-0.36489182722315	33	29	0.00614797540809837	4717	5310	3911,7132,3566,1281,3458,3912,100500837,941,3567,3568,942,2335,3560,3915,940,7057,3565,7059,3932,100616340,3559,3913,3918,958,1277,3558,1278,7133,7535	LAMA5,TNFRSF1A,IL4R,COL3A1,IFNG,LAMB1,MIR3606,CD80,IL5,IL5RA,CD86,FN1,IL2RB,LAMC1,CD28,THBS1,IL4,THBS3,LCK,MIR4758,IL2RA,LAMB2,LAMC2,CD40,COL1A1,IL2,COL1A2,TNFRSF1B,ZAP70
WP430	Statin Pathway	0.694271748119049	-0.36489182722315	33	29	0.00614797540809837	4717	5310	3990,1071,345,3949,335,407039,6646,4023,64714,19,4035,116519,84532,693120,344,3156,348,338,341,4547,949,337,64241,6713,2222,64240,336,5360,1581	LIPC,CETP,APOC3,LDLR,APOA1,MIR33A,SOAT1,LPL,PDIA2,ABCA1,LRP1,APOA5,ACSS1,MIR33B,APOC2,HMGCR,APOE,APOB,APOC1,MTTP,SCARB1,APOA4,ABCG8,SQLE,FDFT1,ABCG5,APOA2,PLTP,CYP7A1
WP1433	Nucleotide-binding Oligomerization Domain (NOD) pathway	0.694447636228732	-0.364638517429097	41	36	0.00763196947212211	4717	5310	29108,64127,5879,22861,842,58484,9744,3320,840,50506,4671,22900,10910,3553,338322,838,834,9447,639,841,51079,91662,4792,5970,3551,55655,4210,3606,199713,8767,84674,55914,1147,10392,114548,147945	PYCARD,NOD2,RAC1,NLRP1,CASP9,NLRC4,ACAP1,HSP90AA1,CASP7,DUOX2,NAIP,CARD8,SUGT1,IL1B,NLRP10,CASP5,CASP1,AIM2,PRDM1,CASP8,NDUFA13,NLRP12,NFKBIA,RELA,IKBKB,NLRP2,MEFV,IL18,NLRP7,RIPK2,CARD6,ERBIN,CHUK,NOD1,NLRP3,NLRP4
WP2865	IL1 and megakaryocytes in obesity	0.697019641002505	-0.36094168927502	25	22	0.00466398134407462	4717	5310	7077,3554,2147,1839,4615,3458,4790,7941,3383,4318,2149,1232,6280,3553,114548,5290,8991,7097,3606,7096,6347,2205	TIMP2,IL1R1,F2,HBEGF,MYD88,IFNG,NFKB1,PLA2G7,ICAM1,MMP9,F2R,CCR3,S100A9,IL1B,NLRP3,PIK3CA,SELENBP1,TLR2,IL18,TLR1,CCL2,FCER1A
WP2916	Interactome of polycomb repressive complex 2 (PRC2)	0.706230243405754	-0.34781397085152	17	15	0.00317998728005088	4717	5310	9967,8178,23512,8726,9774,23515,2146,121536,23087,3720,22823,23064,5928,11329,2145	THRAP3,ELL,SUZ12,EED,BCLAF1,MORC3,EZH2,AEBP2,TRIM35,JARID2,MTF2,SETX,RBBP4,STK38,EZH1
WP262	EBV LMP1 signaling	0.723253261193116	-0.323995826054668	24	21	0.00445198219207123	4717	5310	5594,3576,7189,7185,7124,4215,6885,6364,9020,1147,4792,6352,8717,4790,3320,9260,4791,5599,5970,3456,3551	MAPK1,CXCL8,TRAF6,TRAF1,TNF,MAP3K3,MAP3K7,CCL20,MAP3K14,CHUK,NFKBIA,CCL5,TRADD,NFKB1,HSP90AA1,PDLIM7,NFKB2,MAPK8,RELA,IFNB1,IKBKB
WP561	Heme Biosynthesis	0.734236730744567	-0.30892378091612	9	8	0.00169599321602714	4717	5310	5498,1371,3145,2235,7389,210,211,7390	PPOX,CPOX,HMBS,FECH,UROD,ALAD,ALAS1,UROS
WP288	NLR Proteins	0.734236730744567	-0.30892378091612	9	8	0.00169599321602714	4717	5310	55914,958,6885,2048,3551,1147,5970,5599	ERBIN,CD40,MAP3K7,EPHB2,IKBKB,CHUK,RELA,MAPK8
WP3585	Cytosine methylation	0.734236730744567	-0.30892378091612	9	8	0.00169599321602714	4717	5310	53615,1786,54790,3418,3417,200424,80312,6996	MBD3,DNMT1,TET2,IDH2,IDH1,TET3,TET1,TDG
WP550	Biogenic Amine Synthesis	0.738116891465937	-0.303653077403721	16	14	0.00296798812804749	4717	5310	15,7166,1621,1103,5053,3067,2571,43,100616414,7054,5409,1644,1312,2572	AANAT,TPH1,DBH,CHAT,PAH,HDC,GAD1,ACHE,MIR4761,TH,PNMT,DDC,COMT,GAD2
WP2291	Deregulation of Rab and Rab Effector Genes in Bladder Cancer	0.738116891465937	-0.303653077403721	16	14	0.00296798812804749	4717	5310	25924,8567,22895,5873,23086,9501,84958,54843,83874,94120,79083,5874,9648,201294	MYRIP,MADD,RPH3A,RAB27A,EXPH5,RPH3AL,SYTL1,SYTL2,TBC1D10A,SYTL3,MLPH,RAB27B,GCC2,UNC13D
WP53	ID signaling pathway	0.738116891465937	-0.303653077403721	16	14	0.00296798812804749	4717	5310	3399,4654,5933,6720,2004,3398,5076,2005,898,7849,5934,5925,1017,5079	ID3,MYOD1,RBL1,SREBF1,ELK3,ID2,PAX2,ELK4,CCNE1,PAX8,RBL2,RB1,CDK2,PAX5
WP117	GPCRs, Other	0.741077666737417	-0.299649845767772	95	83	0.0175959296162815	4717	5310	5737,146,118442,128674,29933,4923,26212,140,27202,3355,29929,4994,83873,81050,59340,2911,2492,84059,283383,1880,23284,51289,3356,1131,100616112,9289,84658,8387,393046,1951,1815,1234,1129,9290,64582,2918,53831,2149,6752,9288,26492,154,887,5032,4992,3577,2837,11245,144124,59352,8392,6608,1268,26333,79541,84539,10888,2532,221395,26245,3363,1901,53829,1814,341416,26648,27239,1909,2798,8390,1952,23266,2841,54112,59350,9287,254786,135,3579,30817,9620,9038,2692	PTGFR,ADRA1D,GPR62,PROKR2,GPR132,NTSR1,OR2B6,ADORA3,C5AR2,HTR1F,ALG6,OR3A1,GPR61,OR5AC2,HRH4,GRM1,FSHR,ADGRV1,ADGRD1,GPR183,ADGRL3,RXFP3,HTR2A,CHRM3,MIR4793,ADGRG1,ADGRE3,OR1E1,OR2A5,CELSR3,DRD4,CCR5,CHRM2,GPR55,GPR135,GRM8,GPR84,F2R,SSTR2,TAAR3P,OR8G2P,ADRB2,CCKBR,P2RY11,OR1F1,CXCR1,UTS2R,GPR176,OR10A5,LGR6,OR3A3,SMO,CNR1,OR7A17,OR2A4,MCHR2,GPR83,ACKR1,ADGRF5,OR2M4,HTR7,S1PR1,P2RY13,DRD3,OR6C2,OR7E24,GPR162,EDNRA,GNRHR,OR1G1,CELSR2,ADGRL2,GPR18,GPR88,RXFP1,TAAR2,OR6C3,ADORA2A,CXCR2,ADGRE2,CELSR1,TAAR5,GHRHR
WP623	Oxidative phosphorylation	0.748911306883615	-0.289134717852252	54	47	0.00996396014415942	4717	5310	517,514,518,4717,10632,506,56901,4729,4695,4706,4710,4708,4714,4731,516,4726,4728,4723,27109,513,4725,4698,4712,4696,4705,4716,4700,4718,4704,539,4719,4720,4724,126328,4707,3002,498,10476,4722,515,4702,4715,4711,100616403,522,4697,374291	ATP5MC2,ATP5F1E,ATP5MC3,NDUFC1,ATP5MG,ATP5F1B,NDUFA4L2,NDUFV2,NDUFA2,NDUFAB1,NDUFB4,NDUFB2,NDUFB8,NDUFV3,ATP5MC1,NDUFS6,NDUFS8,NDUFV1,DMAC2L,ATP5F1D,NDUFS5,NDUFA5,NDUFB6,NDUFA3,NDUFA10,NDUFB10,NDUFA6,NDUFC2,NDUFA9,ATP5PO,NDUFS1,NDUFS2,NDUFS4,NDUFA11,NDUFB1,GZMB,ATP5F1A,ATP5PD,NDUFS3,ATP5PB,NDUFA8,NDUFB9,NDUFB5,MIR4691,ATP5PF,NDUFA4,NDUFS7
WP2359	Parkin-Ubiquitin Proteasomal System pathway	0.748955560452983	-0.289075629063595	70	61	0.0129319482722069	4717	5310	841,347688,7278,5711,9861,81027,898,3313,10376,25897,5715,7846,5702,3304,7327,7332,5707,10213,84790,51465,6622,6478,5700,203068,5713,51807,5718,5704,347733,5719,9246,834,3309,7277,8454,3306,3310,3308,5071,118424,7280,51182,5701,55294,84617,10273,10381,5706,5710,2861,3305,3312,5708,7326,79861,5714,112714,10382,6477,5717,9627	CASP8,TUBB8,TUBA3C,PSMD5,PSMD6,TUBB1,CCNE1,HSPA9,TUBA1B,RNF19A,PSMD9,TUBA1A,PSMC3,HSPA1B,UBE2G2,UBE2L3,PSMD1,PSMD14,TUBA1C,UBE2J1,SNCA,SIAH2,PSMC1,TUBB,PSMD7,TUBA8,PSMD12,PSMC4,TUBB2B,PSMD13,UBE2L6,CASP1,HSPA5,TUBA4A,CUL1,HSPA2,HSPA6,HSPA4,PRKN,UBE2J2,TUBB2A,HSPA14,PSMC2,FBXW7,TUBB6,STUB1,TUBB3,PSMC6,PSMD4,GPR37,HSPA1L,HSPA8,PSMD2,UBE2G1,TUBAL3,PSMD8,TUBA3E,TUBB4A,SIAH1,PSMD11,SNCAIP
WP268	Notch Signaling Pathway	0.750613854793119	-0.286863934160709	46	40	0.00847996608013568	4717	5310	4854,3714,5663,9794,23385,3955,3066,1840,4853,6868,9253,54567,5664,1855,4242,10683,23220,9612,51763,5986,3065,113878,196403,8650,55534,8850,3516,3280,1856,83464,182,51107,1857,388585,171558,4855,1487,1387,1488,3762	NOTCH3,JAG2,PSEN1,MAML1,NCSTN,LFNG,HDAC2,DTX1,NOTCH2,ADAM17,NUMBL,DLL4,PSEN2,DVL1,MFNG,DLL3,DTX4,NCOR2,INPP5K,RFNG,HDAC1,DTX2,DTX3,NUMB,MAML3,KAT2B,RBPJ,HES1,DVL2,APH1B,JAG1,APH1A,DVL3,HES5,PTCRA,NOTCH4,CTBP1,CREBBP,CTBP2,KCNJ5
WP3851	TLR4 Signaling and Tolerance	0.76133396071321	-0.272683172820557	30	26	0.00551197795208819	4717	5310	6885,7099,1147,23471,7187,51135,7189,3576,7124,23118,3635,3551,3456,148022,3569,4792,11213,114609,3665,4615,4790,8737,3661,9641,29110,10454	MAP3K7,TLR4,CHUK,TRAM1,TRAF3,IRAK4,TRAF6,CXCL8,TNF,TAB2,INPP5D,IKBKB,IFNB1,TICAM1,IL6,NFKBIA,IRAK3,TIRAP,IRF7,MYD88,NFKB1,RIPK1,IRF3,IKBKE,TBK1,TAB1
WP241	One Carbon Metabolism	0.76133396071321	-0.272683172820557	30	26	0.00551197795208819	4717	5310	7298,191,219595,6472,2618,4522,2745,123263,4143,4552,1788,1786,6470,27430,10797,10840,275,23382,635,1719,471,25902,2346,10588,4548,4524	TYMS,AHCY,FOLH1B,SHMT2,GART,MTHFD1,GLRX,MTFMT,MAT1A,MTRR,DNMT3A,DNMT1,SHMT1,MAT2B,MTHFD2,ALDH1L1,AMT,AHCYL2,BHMT,DHFR,ATIC,MTHFD1L,FOLH1,MTHFS,MTR,MTHFR
WP197	Cholesterol Biosynthesis	0.769517173240042	-0.261992008551268	15	13	0.0027559889760441	4717	5310	10654,3156,3157,6713,2222,4598,4597,6309,2224,6307,1595,1717,3422	PMVK,HMGCR,HMGCS1,SQLE,FDFT1,MVK,MVD,SC5D,FDPS,MSMO1,CYP51A1,DHCR7,IDI1
WP545	Complement Activation	0.77436581051625	-0.255710893637666	22	19	0.00402798388806445	4717	5310	629,1604,715,730,1675,727,718,713,714,5648,732,717,729,712,10747,731,716,735,720	CFB,CD55,C1R,C7,CFD,C5,C3,C1QB,C1QC,MASP1,C8B,C2,C6,C1QA,MASP2,C8A,C1S,C9,C4A
WP272	Blood Clotting Cascade	0.77436581051625	-0.255710893637666	22	19	0.00402798388806445	4717	5310	2244,2165,7450,5340,5054,5328,5327,2266,2155,2243,2147,2159,2153,2161,5345,3816,3818,2160,5055	FGB,F13B,VWF,PLG,SERPINE1,PLAU,PLAT,FGG,F7,FGA,F2,F10,F5,F12,SERPINF2,KLK1,KLKB1,F11,SERPINB2
WP1584	Type II diabetes mellitus	0.77436581051625	-0.255710893637666	22	19	0.00402798388806445	4717	5310	3651,723961,3767,3667,2475,389692,5594,773,6514,7124,5590,122809,5580,9370,5599,23533,3551,3643,6517	PDX1,INS-IGF2,KCNJ11,IRS1,MTOR,MAFA,MAPK1,CACNA1A,SLC2A2,TNF,PRKCZ,SOCS4,PRKCD,ADIPOQ,MAPK8,PIK3R5,IKBKB,INSR,SLC2A4
WP1589	Folate-Alcohol and Cancer Pathway	0.777816849838723	-0.251264194035737	8	7	0.00148399406402374	4717	5310	875,1051,216,1385,4524,10840,128	CBS,CEBPB,ALDH1A1,CREB1,MTHFR,ALDH1L1,ADH5
WP2267	Synaptic Vesicle Pathway	0.780756710632474	-0.247491687745449	52	45	0.00953996184015264	4717	5310	1759,140679,5864,6809,8218,6570,6507,163,10059,440279,81539,8224,6532,10815,22999,160,6854,594855,6812,11315,477,773,2055,6857,57084,2054,6844,1785,246213,26052,1175,291,6616,10814,23025,1213,10497,1211,4905,57030,6581,112755,161,6571,1173	DNM1,SLC32A1,RAB3A,STX3,CLTCL1,SLC18A1,SLC1A3,AP2B1,DNM1L,UNC13C,SLC38A1,SYN3,SLC6A4,CPLX1,RIMS1,AP2A1,SYN2,CPLX3,STXBP1,PARK7,ATP1A2,CACNA1A,CLN8,SYT1,SLC17A6,STX2,VAMP2,DNM2,SLC17A8,DNM3,AP2S1,SLC25A4,SNAP25,CPLX2,UNC13A,CLTC,UNC13B,CLTA,NSF,SLC17A7,SLC22A3,STX1B,AP2A2,SLC18A2,AP2M1
WP422	MAPK Cascade	0.782733245651248	-0.244963323474522	29	25	0.0052999788000848	4717	5310	673,5602,5595,6237,4214,10746,3725,6300,5605,6416,4893,4133,1432,5331,6494,5894,3265,5604,3845,5609,5594,4215,5606,4155,5608	BRAF,MAPK10,MAPK3,RRAS,MAP3K1,MAP3K2,JUN,MAPK12,MAP2K2,MAP2K4,NRAS,MAP2,MAPK14,PLCB3,SIPA1,RAF1,HRAS,MAP2K1,KRAS,MAP2K7,MAPK1,MAP3K3,MAP2K3,MBP,MAP2K6
WP716	Vitamin A and Carotenoid Metabolism	0.78509313398509	-0.241952926217914	44	38	0.0080559677761289	4717	5310	195814,116362,216,5950,6121,145226,1382,6820,5959,5594,1381,6817,4023,5915,127,29881,64240,54884,124,948,9249,220,5914,53630,6256,50700,157506,6258,5916,9227,6017,5948,5947,8854,1592,949,64241,56603	SDR16C5,RBP7,ALDH1A1,RBP4,RPE65,RDH12,CRABP2,SULT2B1,RDH5,MAPK1,CRABP1,SULT1A1,LPL,RARB,ADH4,NPC1L1,ABCG5,RETSAT,ADH1A,CD36,DHRS3,ALDH1A3,RARA,BCO1,RXRA,RDH8,RDH10,RXRG,RARG,LRAT,RLBP1,RBP2,RBP1,ALDH1A2,CYP26A1,SCARB1,ABCG8,CYP26B1
WP1311	Folic Acid Network	0.789100695651031	-0.236861341880285	2	2	0.000423998304006784	4717	5310	342184,7295	FMN1,TXN
WP2901	Gonadotropin-releasing hormone (GnRH) signaling	0.789100695651031	-0.236861341880285	2	2	0.000423998304006784	4717	5310	4323,4313	MMP14,MMP2
WP2943	Hypoxia-mediated EMT and Stemness	0.789100695651031	-0.236861341880285	2	2	0.000423998304006784	4717	5310	6935,23405	ZEB1,DICER1
WP2366	Butyrate-induced histone acetylation	0.789100695651031	-0.236861341880285	2	2	0.000423998304006784	4717	5310	47,207	ACLY,AKT1
WP2866	mir34a and TGIF2 in osteoclastogenesis	0.789100695651031	-0.236861341880285	2	2	0.000423998304006784	4717	5310	407040,60436	MIR34A,TGIF2
WP1273	Folic Acid Network	0.789100695651031	-0.236861341880285	2	2	0.000423998304006784	4717	5310	7295,342184	TXN,FMN1
WP2646	Lidocaine metabolism	0.789100695651031	-0.236861341880285	2	2	0.000423998304006784	4717	5310	1544,1576	CYP1A2,CYP3A4
WP500	Glycogen Metabolism	0.792114470943742	-0.23304936359187	36	31	0.00657197371210515	4717	5310	5836,5525,7360,5837,2932,5522,5257,805,5261,2997,5834,2998,2931,5521,5236,5515,2632,5529,5528,5527,5523,5526,2992,5518,5516,5524,801,5519,178,808,5520	PYGL,PPP2R5A,UGP2,PYGM,GSK3B,PPP2R2C,PHKB,CALM2,PHKG2,GYS1,PYGB,GYS2,GSK3A,PPP2R2B,PGM1,PPP2CA,GBE1,PPP2R5E,PPP2R5D,PPP2R5C,PPP2R3A,PPP2R5B,GYG1,PPP2R1A,PPP2CB,PTPA,CALM1,PPP2R1B,AGL,CALM3,PPP2R2A
WP2436	Dopamine metabolism	0.800143292906441	-0.222964451220538	14	12	0.0025439898240407	4717	5310	5516,1312,7299,1728,5568,5567,7054,100616414,5515,5566,1644,6647	PPP2CB,COMT,TYR,NQO1,PRKACG,PRKACB,TH,MIR4761,PPP2CA,PRKACA,DDC,SOD1
WP2853	Endoderm Differentiation	0.813829367353944	-0.206004557368748	145	126	0.0267118931524274	4717	5310	3175,1499,6875,6928,406933,23007,5916,3915,6657,123169,7478,7473,6671,31,23682,23576,4830,655,58499,26986,9682,154091,4089,10459,4088,121536,30009,6772,6478,442918,3975,115825,2131,11169,9646,51176,27245,55832,79977,51460,64321,8320,5460,2308,83881,29970,2146,57690,2186,79577,9760,9241,351,1112,3198,2005,23168,22823,1847,4087,5015,3170,324,22943,2908,131405,10153,7709,27244,1994,10128,8554,23286,1601,23373,9350,5083,5090,9425,27324,9573,6925,57198,23528,6422,63978,1846,85363,10451,56946,2626,3169,83595,55809,657,11166,57669,64864,6932,54623,7040,79776,7080,5744,85416,5077,11190,5087,1488,54799,79923,83439,26610,6877,2736,1844,54892,51366,5606,6001,4838,10973,9044,3720,80312,3087	ONECUT1,CTNNB1,TAF4B,HNF1B,MIR141,PLCH1,RARG,LAMC1,SOX2,LEO1,WNT8A,WNT3,SP4,ACACA,RAB38,DDAH1,NME1,BMP7,ZNF462,PABPC1,KDM4A,SLC2A12,SMAD4,MAD2L2,SMAD3,AEBP2,TBX21,STAT1,SIAH2,MIR373,LHX1,WDFY2,EXT1,WDHD1,CTR9,LEF1,AHDC1,CAND1,GRHL2,SFMBT1,SOX17,EOMES,POU5F1,FOXO1,MIXL1,SCHIP1,EZH2,TNRC6C,BPTF,CDC73,TOX,NOG,APP,FOXN3,HOXA1,ELK4,RTF1,MTF2,DUSP5,SMAD2,OTX2,FOXA2,APC,DKK1,NR3C1,TRIM71,CEBPZ,ZBTB17,SESN1,ELAVL1,LRPPRC,PIAS1,WWC1,DAB2,CRTC1,CER1,PAX9,PBX3,CDYL,TOX3,GDF3,TCF4,ATP8B2,ZNF281,SFRP1,PRDM14,DUSP4,TRIM5,VAV3,EMSY,GATA4,FOXA1,SOX7,TRERF1,BMPR1A,SOX21,EPB41L5,RFX7,TCF7,PAF1,TGFB1,ZFHX4,NKX2-1,PTHLH,ZIC5,PAX3,CEP250,PBX1,CTBP2,MBTD1,NANOG,TCF7L1,ELP4,TAF5,GLI2,DUSP2,NCAPG2,UBR5,MAP2K3,RGS10,NODAL,ASCC3,BTAF1,JARID2,TET1,HHEX
WP1449	Regulation of toll-like receptor signaling pathway	0.813829367353944	-0.206004557368748	145	126	0.0267118931524274	4717	5310	5605,7124,4153,7098,6373,8727,6348,54106,1326,7099,7100,11213,6352,729238,4791,3593,5601,3456,353376,3665,3553,5606,3929,1154,6441,4064,3455,5599,6696,208,3661,8737,8878,207,79004,6416,7097,3725,3576,1147,3454,4792,5602,246330,148022,6351,3439,6850,8651,406891,3452,54472,57162,2353,958,3443,59307,3448,1540,5293,5604,5600,10616,4790,8503,3449,23118,7096,3663,7187,3442,10333,10000,4091,10771,941,3551,5347,5777,5595,54210,8772,3444,3440,114609,5609,5294,5603,5608,841,5290,10454,5879,9641,6300,942,3441,51135,7189,5291,1432,6885,3627,7128,57161,54476,5295,3569,64223,23533,3445,5970,10906,7874,3592,10193,51014,5594,92610,29110,23643,4615,929,6772,5296,3656	MAP2K2,TNF,MBL2,TLR3,CXCL11,CTNNAL1,CCL3,TLR9,MAP3K8,TLR4,TLR5,IRAK3,CCL5,SFTPA2,NFKB2,IL12B,MAPK9,IFNB1,TICAM2,IRF7,IL1B,MAP2K3,LBP,CISH,SFTPD,CD180,IFNAR2,MAPK8,SPP1,AKT2,IRF3,RIPK1,SQSTM1,AKT1,CUEDC2,MAP2K4,TLR2,JUN,CXCL8,CHUK,IFNAR1,NFKBIA,MAPK10,PELI3,TICAM1,CCL4,IFNA1,SYK,SOCS1,MIRLET7I,IFNA21,TOLLIP,PELI1,FOS,CD40,IFNA6,SIGIRR,IFNA14,CYLD,PIK3CD,MAP2K1,MAPK11,RBCK1,NFKB1,PIK3R3,IFNA16,TAB2,TLR1,IRF5,TRAF3,IFNA5,TLR6,AKT3,SMAD6,ZMYND11,CD80,IKBKB,PLK1,PTPN6,MAPK3,TREM1,FADD,IFNA7,IFNA2,TIRAP,MAP2K7,PIK3CG,MAPK13,MAP2K6,CASP8,PIK3CA,TAB1,RAC1,IKBKE,MAPK12,CD86,IFNA4,IRAK4,TRAF6,PIK3CB,MAPK14,MAP3K7,CXCL10,TNFAIP3,PELI2,RNF216,PIK3R1,IL6,MLST8,PIK3R5,IFNA8,RELA,TRAFD1,USP7,IL12A,RNF41,TMED7,MAPK1,TIFA,TBK1,LY96,MYD88,CD14,STAT1,PIK3R2,IRAK2
WP3924	Hfe effect on hepcidin production	0.820733230128323	-0.197557155184052	7	6	0.00127199491202035	4717	5310	164656,654,3077,57817,4092,148738	TMPRSS6,BMP6,HFE,HAMP,SMAD7,HJV
WP1995	Effects of Nitric Oxide	0.820733230128323	-0.197557155184052	7	6	0.00127199491202035	4717	5310	4151,4842,7498,4846,316,3039	MB,NOS1,XDH,NOS3,AOX1,HBA1
WP134	Pentose Phosphate Pathway	0.820733230128323	-0.197557155184052	7	6	0.00127199491202035	4717	5310	22934,6888,6120,25796,5226,7086	RPIA,TALDO1,RPE,PGLS,PGD,TKT
WP699	Aflatoxin B1 metabolism	0.820733230128323	-0.197557155184052	7	6	0.00127199491202035	4717	5310	22977,1553,2944,1576,2052,1544	AKR7A3,CYP2A13,GSTM1,CYP3A4,EPHX1,CYP1A2
WP528	Acetylcholine Synthesis	0.820733230128323	-0.197557155184052	7	6	0.00127199491202035	4717	5310	1119,5130,43,10400,5161,1103	CHKA,PCYT1A,ACHE,PEMT,PDHA2,CHAT
WP1742	TP53 Network	0.822633153597708	-0.195244920572606	20	17	0.00360398558405766	4717	5310	1647,4193,8743,5015,472,7157,25,7341,7161,5366,27113,8626,1026,596,4609,581,1029	GADD45A,MDM2,TNFSF10,OTX2,ATM,TP53,ABL1,SUMO1,TP73,PMAIP1,BBC3,TP63,CDKN1A,BCL2,MYC,BAX,CDKN2A
WP391	Mitochondrial Gene Expression	0.822633153597708	-0.195244920572606	20	17	0.00360398558405766	4717	5310	51106,2101,1385,10891,6667,5530,7019,814,51001,23082,2551,64216,4899,50804,133522,5442,7978	TFB1M,ESRRA,CREB1,PPARGC1A,SP1,PPP3CA,TFAM,CAMK4,MTERF3,PPRC1,GABPA,TFB2M,NRF1,MYEF2,PPARGC1B,POLRMT,MTERF1
WP143	Fatty Acid Beta Oxidation	0.827597925575037	-0.189227839668944	34	29	0.00614797540809837	4717	5310	38,4023,51703,3032,8513,3990,1632,1666,2181,2820,23305,1738,35,2712,1384,34,33,788,1374,37,3030,2639,2180,3991,57104,1376,7167,3033,55902	ACAT1,LPL,ACSL5,HADHB,LIPF,LIPC,ECI1,DECR1,ACSL3,GPD2,ACSL6,DLD,ACADS,GK2,CRAT,ACADM,ACADL,SLC25A20,CPT1A,ACADVL,HADHA,GCDH,ACSL1,LIPE,PNPLA2,CPT2,TPI1,HADH,ACSS2
WP400	p38 MAPK Signaling Pathway	0.827597925575037	-0.189227839668944	34	29	0.00614797540809837	4717	5310	5608,7042,4149,3265,8737,6772,1385,9261,5879,5321,1616,2885,1432,998,6885,4609,6464,4217,9252,6416,8717,7046,3315,4214,4293,3150,4209,1386,5923	MAP2K6,TGFB2,MAX,HRAS,RIPK1,STAT1,CREB1,MAPKAPK2,RAC1,PLA2G4A,DAXX,GRB2,MAPK14,CDC42,MAP3K7,MYC,SHC1,MAP3K5,RPS6KA5,MAP2K4,TRADD,TGFBR1,HSPB1,MAP3K1,MAP3K9,HMGN1,MEF2D,ATF2,RASGRF1
WP1991	SRF and miRs in Smooth Muscle Differentiation and Proliferation	0.829685384410372	-0.186708704978235	13	11	0.00233199067203731	4717	5310	4208,894,9314,4205,4209,817,100271849,1482,406976,6722,93649	MEF2C,CCND2,KLF4,MEF2A,MEF2D,CAMK2D,MEF2B,NKX2-5,MIR199A1,SRF,MYOCD
WP1772	Apoptosis Modulation and Signaling	0.840151470799042	-0.174173081021092	94	81	0.0171719313122748	4717	5310	1677,1616,839,10017,8567,638,4170,598,8737,5599,27429,597,51651,2021,640,4671,596,8772,841,8795,5587,9020,7132,90427,8718,355,5595,3551,835,8793,7850,4217,7187,1029,842,8739,836,1676,57448,840,4615,8738,4790,3554,54472,7157,329,51155,578,834,356,84883,2353,7133,837,79444,330,54205,664,8794,4792,8717,4982,8743,332,317,5783,8837,56616,3725,8682,7189,5366,27113,55367,8797,5414,843,10018,9531,581	DFFB,DAXX,CASP6,BCL2L10,MADD,BIK,MCL1,BCL2L1,RIPK1,MAPK8,HTRA2,BCL2A1,PTRH2,ENDOG,BLK,NAIP,BCL2,FADD,CASP8,TNFRSF10B,PRKD1,MAP3K14,TNFRSF1A,BMF,TNFRSF25,FAS,MAPK3,IKBKB,CASP2,TNFRSF10D,IL1R2,MAP3K5,TRAF3,CDKN2A,CASP9,HRK,CASP3,DFFA,BIRC6,CASP7,MYD88,CRADD,NFKB1,IL1R1,TOLLIP,TP53,BIRC2,JPT1,BAK1,CASP1,FASLG,AIFM2,FOS,TNFRSF1B,CASP4,BIRC7,BIRC3,CYCS,BNIP3,TNFRSF10C,NFKBIA,TRADD,TNFRSF11B,TNFSF10,BIRC5,APAF1,PTPN13,CFLAR,DIABLO,JUN,PEA15,TRAF6,PMAIP1,BBC3,PIDD1,TNFRSF10A,SEPTIN4,CASP10,BCL2L11,BAG3,BAX
WP2363	Gastric Cancer Network 2	0.844317011166475	-0.169227249260841	33	28	0.00593597625609498	4717	5310	63922,5984,11065,27101,51316,255488,84823,3930,92140,157769,79075,4609,5983,29028,29089,1499,55215,10153,6277,25909,55299,1299,1297,1956,5884,962,7153,7157	CHTF18,RFC4,UBE2C,CACYBP,PLAC8,RNF144B,LMNB2,LBR,MTDH,FAM91A1,DSCC1,MYC,RFC3,ATAD2,UBE2T,CTNNB1,FANCI,CEBPZ,S100A6,AHCTF1,BRIX1,COL9A3,COL9A1,EGFR,RAD17,CD48,TOP2A,TP53
WP384	Apoptosis Modulation by HSP70	0.84530054394623	-0.168063041552573	19	16	0.00339198643205427	4717	5310	842,54205,839,7132,836,5602,355,840,4790,8737,317,4214,835,8772,841,356	CASP9,CYCS,CASP6,TNFRSF1A,CASP3,MAPK10,FAS,CASP7,NFKB1,RIPK1,APAF1,MAP3K1,CASP2,FADD,CASP8,FASLG
WP697	Estrogen metabolism	0.84530054394623	-0.168063041552573	19	16	0.00339198643205427	4717	5310	54658,7364,2938,1544,1312,1545,1728,54659,54578,6817,6783,1576,1543,2944,54600,100616414	UGT1A1,UGT2B7,GSTA1,CYP1A2,COMT,CYP1B1,NQO1,UGT1A3,UGT1A6,SULT1A1,SULT1E1,CYP3A4,CYP1A1,GSTM1,UGT1A9,MIR4761
WP2369	Histone Modifications	0.858151366229904	-0.152974777536544	69	59	0.0125079499682001	4717	5310	6419,79723,8352,8366,8726,8368,387893,9757,8363,6418,64324,84787,3021,133383,8365,8350,55209,55904,8354,29072,55870,121536,51111,80854,58508,54093,26040,126961,8361,150572,8357,121504,83852,84444,7799,8367,79918,653604,56950,2146,8355,9869,23067,8968,8360,4297,8364,64754,84193,114826,8359,8362,10322,10919,2145,8353,3020,693140,8358	SETMAR,SUV39H2,H3C3,H4C2,EED,H4C13,KMT5A,KMT2B,H4C11,SET,NSD1,KMT5C,H3-3B,SETD9,H4C8,H3C1,SETD5,KMT2E,H3C11,SETD2,ASH1L,AEBP2,KMT5B,SETD7,KMT2C,SETD4,SETBP1,H3C14,H4C6,SMYD1,H3C10,H4C16,SETDB2,DOT1L,PRDM2,H4C5,SETD6,H3C13,SMYD2,EZH2,H3C8,SETDB1,SETD1B,H3C7,H4C4,KMT2A,H4C3,SMYD3,SETD3,SMYD4,H4C1,H4C12,SMYD5,EHMT2,EZH1,H3C6,H3-3A,MIR555,H3C2
WP2857	Mesodermal Commitment Pathway	0.860160698650933	-0.150636048294099	155	134	0.0284078863684545	4717	5310	6911,8030,51366,54892,6001,4838,442917,10973,2260,3720,80312,55704,5515,57669,11166,657,203228,79776,7044,11190,2253,85416,54799,79923,5087,1488,26610,8313,83439,652,343930,10413,57198,6925,23528,84159,7855,5566,29072,85363,56946,10451,55809,4086,3169,22943,131405,9421,8728,27244,6926,8554,90,2625,688,23373,9573,27324,3624,5090,10124,92,9760,4780,2296,9241,9113,3064,22823,6899,2005,8322,8646,4087,3170,8091,5080,8553,442918,2131,404220,6169,115825,6615,1466,51176,10637,27245,11169,79977,64321,3172,5460,4091,83881,8320,2303,29970,8312,406911,6722,5915,7546,23576,655,100423031,8325,5573,154091,58499,3717,4089,4211,4088,121536,9314,2132,8463,23499,406933,84667,5308,6657,23007,5916,7003,7473,595,268,659,31,93,89780,57045	TBX6,CCDC6,UBR5,NCAPG2,RGS10,NODAL,MIR372,ASCC3,FGFR1,JARID2,TET1,CCDC88A,PPP2CA,EPB41L5,SOX21,BMPR1A,C9orf72,ZFHX4,LEFTY2,CEP250,FGF8,ZIC5,MBTD1,NANOG,PBX1,CTBP2,ELP4,AXIN2,TCF7L1,BMP4,MSGN1,YAP1,ATP8B2,TCF4,ZNF281,ARID5B,FZD5,PRKACA,SETD2,TRIM5,EMSY,VAV3,TRERF1,SMAD1,FOXA1,DKK1,TRIM71,HAND1,ADAM19,SESN1,TBX3,PIAS1,ACVR1,GATA3,KLF5,CRTC1,GDF3,TOX3,INHBA,PBX3,ARL4A,ACVR2A,TOX,NFE2L2,FOXC1,NOG,LATS1,HTT,MTF2,TBX1,ELK4,FZD4,CHRD,SMAD2,FOXA2,HMGA2,PAX6,BHLHE40,MIR373,EXT1,TEX56P,RPL38,WDFY2,SNAI1,CSRP2,LEF1,LEFTY1,AHDC1,WDHD1,GRHL2,SOX17,HNF4A,POU5F1,SMAD6,MIXL1,EOMES,FOXC2,SCHIP1,AXIN1,MIR125B1,SRF,RARB,ZIC2,DDAH1,BMP7,MIR4321,FZD8,PRKAR1A,SLC2A12,ZNF462,JAK2,SMAD4,MEIS1,SMAD3,AEBP2,KLF4,EXT2,TEAD2,MACF1,MIR141,HES7,PITX2,SOX2,PLCH1,RARG,TEAD1,WNT3,CCND1,AMH,BMPR2,ACACA,ACVR2B,WNT3A,TWSG1
WP3858	Toll-like Receptor Signaling	0.860278406856362	-0.150499213220732	32	27	0.00572397710409158	4717	5310	3551,5970,148022,4791,5966,1147,7187,7100,10333,7099,7097,7098,7189,54106,51135,7096,3661,9641,4790,4615,5971,29110,3665,353376,5594,114609,54472	IKBKB,RELA,TICAM1,NFKB2,REL,CHUK,TRAF3,TLR5,TLR6,TLR4,TLR2,TLR3,TRAF6,TLR9,IRAK4,TLR1,IRF3,IKBKE,NFKB1,MYD88,RELB,TBK1,IRF7,TICAM2,MAPK1,TIRAP,TOLLIP
WP170	Nuclear Receptors	0.862123662251609	-0.148356558919159	39	33	0.00699597201611194	4717	5310	2100,2099,5914,9975,6256,5241,7376,3172,6258,8856,6097,2063,5916,2494,2103,5468,7068,7026,5467,2908,7421,2101,6095,2516,10062,4929,7025,9970,7101,4919,5465,5915,3164	ESR2,ESR1,RARA,NR1D2,RXRA,PGR,NR1H2,HNF4A,RXRG,NR1I2,RORC,NR2F6,RARG,NR5A2,ESRRB,PPARG,THRB,NR2F2,PPARD,NR3C1,VDR,ESRRA,RORA,NR5A1,NR1H3,NR4A2,NR2F1,NR1I3,NR2E1,ROR1,PPARA,RARB,NR4A1
WP3891	Benzene metabolism	0.862132496070895	-0.148346312391411	6	5	0.00105999576001696	4717	5310	2052,1728,2944,27294,4353	EPHX1,NQO1,GSTM1,DHDH,MPO
WP3878	ATM Signaling Network in Development and Disease	0.865324850848518	-0.144650292437658	46	39	0.00826796692813229	4717	5310	64421,165918,1111,699,4790,7249,9656,5524,10111,80254,7158,8851,23300,2475,9212,1386,5923,1020,11200,3930,9025,4683,3150,472,983,3315,55183,9810,4361,8493,545,5591,9759,4217,10524,5562,6794,5536,56254	DCLRE1C,RNF168,CHEK1,BUB1,NFKB1,TSC2,MDC1,PTPA,RAD50,CEP63,TP53BP1,CDK5R1,ATMIN,MTOR,AURKB,ATF2,RASGRF1,CDK5,CHEK2,LBR,RNF8,NBN,HMGN1,ATM,CDK1,HSPB1,RIF1,RNF40,MRE11,PPM1D,ATR,PRKDC,HDAC4,MAP3K5,KAT5,PRKAA1,STK11,PPP5C,RNF20
WP692	Sulfation Biotransformation Reaction	0.866779988276402	-0.142970096484915	18	15	0.00317998728005088	4717	5310	2936,6799,27284,391365,100526831,6822,6817,442038,25830,6783,9060,6819,6820,9061,27233	GSR,SULT1A2,SULT1B1,SULT6B1,SLX1B-SULT1A4,SULT2A1,SULT1A1,SULT1C3,SULT4A1,SULT1E1,PAPSS2,SULT1C2,SULT2B1,PAPSS1,SULT1C4
WP2854	Gene regulatory network modelling somitogenesis	0.884195558296172	-0.123077021017934	11	9	0.00190799236803053	4717	5310	2043,89780,3280,84667,3955,2253,6911,134701,145873	EPHA4,WNT3A,HES1,HES7,LFNG,FGF8,TBX6,RIPPLY2,MESP2
WP80	Nucleotide GPCRs	0.884195558296172	-0.123077021017934	11	9	0.00190799236803053	4717	5310	1241,5028,136,135,10161,5031,5029,134,140	LTB4R,P2RY1,ADORA2B,ADORA2A,LPAR6,P2RY6,P2RY2,ADORA1,ADORA3
WP1455	Serotonin Transporter Activity	0.884195558296172	-0.123077021017934	11	9	0.00190799236803053	4717	5310	7041,3690,5516,3553,3554,6532,4842,10066,121278	TGFB1I1,ITGB3,PPP2CB,IL1B,IL1R1,SLC6A4,NOS1,SCAMP2,TPH2
WP554	ACE Inhibitor Pathway	0.886921249056861	-0.119999084089961	17	14	0.00296798812804749	4717	5310	4306,1215,183,185,623,1585,624,3827,7040,4846,5972,1636,4142,1511	NR3C2,CMA1,AGT,AGTR1,BDKRB1,CYP11B2,BDKRB2,KNG1,TGFB1,NOS3,REN,ACE,MAS1,CTSG
WP183	Proteasome Degradation	0.887435567608156	-0.119419360146199	66	56	0.01187195251219	4717	5310	5717,10197,8335,5691,3105,6184,3136,5714,5708,5710,3133,5706,5695,7323,5682,7314,5701,3106,5687,7345,7321,5699,5684,5696,3135,5698,5693,5713,5704,7320,5718,5700,5692,3134,3458,3015,5685,7316,5720,7318,7347,5719,100847079,5707,3137,4734,5686,3107,5715,5690,6185,5702,5694,7322,5711,9861	PSMD11,PSME3,H2AC4,PSMB3,HLA-A,RPN1,HLA-H,PSMD8,PSMD2,PSMD4,HLA-E,PSMC6,PSMB7,UBE2D3,PSMA1,UBB,PSMC2,HLA-B,PSMA6,UCHL1,UBE2D1,PSMB10,PSMA3,PSMB8,HLA-G,PSMB9,PSMB5,PSMD7,PSMC4,UBE2B,PSMD12,PSMC1,PSMB4,HLA-F,IFNG,H2AZ1,PSMA4,UBC,PSME1,UBA7,UCHL3,PSMD13,MIR5193,PSMD1,HLA-J,NEDD4,PSMA5,HLA-C,PSMD9,PSMB2,RPN2,PSMC3,PSMB6,UBE2D2,PSMD5,PSMD6
WP3191	TSLP Signaling Pathway	0.888323917146412	-0.118418830941664	1	1	0.000211999152003392	4717	5310	2475	MTOR
WP2190	One carbon donor	0.888323917146412	-0.118418830941664	1	1	0.000211999152003392	4717	5310	4524	MTHFR
WP1	Statin Pathway	0.888323917146412	-0.118418830941664	1	1	0.000211999152003392	4717	5310	1071	CETP
WP2536	Colchicine Metabolic Pathway	0.888323917146412	-0.118418830941664	1	1	0.000211999152003392	4717	5310	1576	CYP3A4
WP661	Glucose Homeostasis	0.888323917146412	-0.118418830941664	1	1	0.000211999152003392	4717	5310	3630	INS
WP188	Focal Adhesion	0.888323917146412	-0.118418830941664	1	1	0.000211999152003392	4717	5310	3691	ITGB4
WP108	Selenium metabolism/Selenoproteins	0.888323917146412	-0.118418830941664	1	1	0.000211999152003392	4717	5310	9403	SELENOF
WP3414	Initiation of transcription and translation elongation at the HIV-1 LTR	0.888427910631627	-0.118301770715573	37	31	0.00657197371210515	4717	5310	1387,4792,904,5530,5534,5970,4775,9734,7469,51497,3065,9759,8841,4772,5533,4776,5532,100302237,6829,4773,4790,6827,6667,10014,7936,5535,3066,51564,2033,100126332,100302242	CREBBP,NFKBIA,CCNT1,PPP3CA,PPP3R1,RELA,NFATC3,HDAC9,NELFA,NELFCD,HDAC1,HDAC4,HDAC3,NFATC1,PPP3CC,NFATC4,PPP3CB,MIR1281,SUPT5H,NFATC2,NFKB1,SUPT4H1,SP1,HDAC5,NELFE,PPP3R2,HDAC2,HDAC7,EP300,MIR943,MIR1236
WP3298	Melatonin metabolism and effects	0.900490208272154	-0.104815988081931	36	30	0.00635997456010176	4717	5310	406938,1544,153,9575,8864,1453,23411,1889,4790,1543,8863,801,1454,5578,406,1565,1906,2308,815,5187,348,1408,7189,43,1407,805,1545,2932,1557,4133	MIR146A,CYP1A2,ADRB1,CLOCK,PER2,CSNK1D,SIRT1,ECE1,NFKB1,CYP1A1,PER3,CALM1,CSNK1E,PRKCA,BMAL1,CYP2D6,EDN1,FOXO1,CAMK2A,PER1,APOE,CRY2,TRAF6,ACHE,CRY1,CALM2,CYP1B1,GSK3B,CYP2C19,MAP2
WP3596	miR-517 relationship with ARCN1 and USP1	0.900958032976952	-0.104296600730574	5	4	0.000847996608013568	4717	5310	7398,372,1026,3398	USP1,ARCN1,CDKN1A,ID2
WP311	Synthesis and Degradation of Ketone Bodies	0.900958032976952	-0.104296600730574	5	4	0.000847996608013568	4717	5310	38,622,5019,3155	ACAT1,BDH1,OXCT1,HMGCL
WP1946	Cori Cycle	0.905585060919376	-0.0991740680038962	16	13	0.0027559889760441	4717	5310	5232,5223,6517,6513,5214,7167,3939,2597,2821,6514,3630,3098,6888	PGK2,PGAM1,SLC2A4,SLC2A1,PFKP,TPI1,LDHA,GAPDH,GPI,SLC2A2,INS,HK1,TALDO1
WP3601	Composition of Lipid Particles	0.908483217115158	-0.0959788644974366	10	8	0.00169599321602714	4717	5310	4023,348,338,3949,335,345,336,1071	LPL,APOE,APOB,LDLR,APOA1,APOC3,APOA2,CETP
WP3656	Interleukin-1 Induced Activation of NF-kappa-B	0.908483217115158	-0.0959788644974366	10	8	0.00169599321602714	4717	5310	92610,7335,8878,84962,7334,7189,3552,5590	TIFA,UBE2V1,SQSTM1,AJUBA,UBE2N,TRAF6,IL1A,PRKCZ
WP3657	Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex	0.909495552324249	-0.0948651712786347	22	18	0.00381598473606106	4717	5310	5728,596,2322,6597,2551,2033,7014,3002,100302237,1788,4089,1786,1387,2120,2309,472,4170,598	PTEN,BCL2,FLT3,SMARCA4,GABPA,EP300,TERF2,GZMB,MIR1281,DNMT3A,SMAD4,DNMT1,CREBBP,ETV6,FOXO3,ATM,MCL1,BCL2L1
WP3872	Regulation of Apoptosis by Parathyroid Hormone-related Protein	0.909495552324249	-0.0948651712786347	22	18	0.00381598473606106	4717	5310	4170,598,207,3691,597,79370,3655,10017,578,23786,2932,5294,5744,581,4609,440603,2931,596	MCL1,BCL2L1,AKT1,ITGB4,BCL2A1,BCL2L14,ITGA6,BCL2L10,BAK1,BCL2L13,GSK3B,PIK3CG,PTHLH,BAX,MYC,BCL2L15,GSK3A,BCL2
WP405	Eukaryotic Transcription Initiation	0.91033223858116	-0.0939456487611244	42	35	0.00741997032011872	4717	5310	64425,2071,1022,2958,2961,2959,6880,5439,6884,25885,5430,51082,55718,6879,5434,6877,84172,4331,2965,3611,6883,2960,728340,171568,2068,661,5440,902,55703,51728,2963,2968,5431,2967,5432	POLR1E,ERCC3,CDK7,GTF2A2,GTF2E2,GTF2B,TAF9,POLR2J,TAF13,POLR1A,POLR2A,POLR1D,POLR3E,TAF7,POLR2E,TAF5,POLR1B,MNAT1,GTF2H1,ILK,TAF12,GTF2E1,GTF2H2C,POLR3H,ERCC2,POLR3D,POLR2K,CCNH,POLR3B,POLR3K,GTF2F2,GTF2H4,POLR2B,GTF2H3,POLR2C
WP111	Electron Transport Chain	0.916049448920324	-0.0876849322275937	92	78	0.0165359338562646	4717	5310	9481,513,1347,27109,1355,7386,4696,4712,1327,4705,1351,4698,10975,4725,7352,1340,7385,506,1353,10632,4717,518,1337,93974,514,517,7350,4728,4723,4709,516,6391,4726,4714,4708,7381,4731,4695,4729,4710,4706,4702,4715,515,4722,29796,10476,498,1346,6390,6389,522,4697,374291,7351,4711,7384,100616403,1329,4724,509,1345,55967,1339,4719,4720,4704,6341,539,4718,4700,4716,9167,1350,9377,4707,291,6392	SLC25A27,ATP5F1D,COX7A2,DMAC2L,COX15,UQCRFS1,NDUFA3,NDUFB6,COX4I1,NDUFA10,COX8A,NDUFA5,UQCR11,NDUFS5,UCP3,COX6B1,UQCRC2,ATP5F1B,COX11,ATP5MG,NDUFC1,ATP5MC3,COX6A1,ATP5IF1,ATP5F1E,ATP5MC2,UCP1,NDUFS8,NDUFV1,NDUFB3,ATP5MC1,SDHC,NDUFS6,NDUFB8,NDUFB2,UQCRB,NDUFV3,NDUFA2,NDUFV2,NDUFB4,NDUFAB1,NDUFA8,NDUFB9,ATP5PB,NDUFS3,UQCR10,ATP5PD,ATP5F1A,COX7A1,SDHB,SDHA,ATP5PF,NDUFA4,NDUFS7,UCP2,NDUFB5,UQCRC1,MIR4691,COX5B,NDUFS4,ATP5F1C,COX6C,NDUFA12,COX6A2,NDUFS1,NDUFS2,NDUFA9,SCO1,ATP5PO,NDUFC2,NDUFA6,NDUFB10,COX7A2L,COX7C,COX5A,NDUFB1,SLC25A4,SDHD
WP2858	Ectoderm Differentiation	0.927257981190114	-0.075523455272706	143	122	0.0258638965444138	4717	5310	6657,51422,4771,5010,79658,1499,6929,166,51222,5783,51592,1004,10486,114815,345557,157807,8325,9079,3728,2737,25987,2263,54903,8345,57621,56899,91653,8820,4089,55843,4772,3975,1006,5080,6622,440193,6386,5292,11177,5787,29970,114822,8675,5420,7704,7903,6469,25806,6785,8495,4990,81576,54898,8322,51762,3170,7226,6781,8835,5269,9687,5452,79731,6016,2720,1496,2534,2300,7026,54806,6347,6498,27324,6238,4982,54828,56963,1952,7343,57476,1487,4061,4920,3148,7471,56913,5150,3853,7855,27352,152789,9924,22871,4609,79776,657,5236,5467,1501,10634,50937,83439,652,54207,10253,7020,5077,2274,10257,57462,8848,151613,4926,5297,5362,7022,3801,460,51043,9935,57154,83933	SOX2,PRKAG2,NF2,CLDN11,ARHGAP10,CTNNB1,TCF3,TLE5,ZNF219,PTPN13,TRIM33,CDH6,CAP2,SORCS1,PLCXD3,CLVS1,FZD8,LDB2,JUP,GLI3,TSKU,FGFR2,MKS1,H2BC9,ZBTB2,ANKS1B,BOC,HESX1,SMAD4,ARHGAP15,NFATC1,LHX1,CDH8,PAX6,SNCA,CCDC88C,SDCBP,PIM1,BAZ1A,PTPRB,SCHIP1,RHPN1,STX16,PODXL,ZBTB16,ST8SIA4,SHH,VAX2,ELOVL4,PPFIBP2,SIX6,YJU2B,ELOVL2,FZD4,RAB8B,FOXA2,TRPM2,STC1,SOCS2,SERPINB6,GREB1,POU2F2,NARS2,RIT1,GLB1,CTNNA2,FYN,FOXL1,NR2F2,AHI1,CCL2,SKIL,TOX3,RRBP1,TNFRSF11B,BCAS3,RGMA,CELSR2,UBTF,GRAMD1B,CTBP1,LY6E,ROR2,HMGB2,WNT1,C1GALT1,PDE7A,KRT6A,FZD5,SGSM3,JAKMIP1,PAN2,NLGN1,MYC,ZFHX4,BMPR1A,PGM1,PPARD,CTNND2,GAS2L1,CDON,TCF7L1,BMP4,KCNK10,SPRY2,TFAP2A,PAX3,FHL2,ABCC4,MYORG,TSC22D1,TTC14,NUMA1,PI4KA,PLXNA2,TFAP2C,KIFC3,ASTN1,ZBTB7B,MAFB,SMURF1,HDAC10
WP3297	EV release from cardiac cells and their functional effects	0.930347266677157	-0.0721973575039427	9	7	0.00148399406402374	4717	5310	7124,6387,2066,5617,10365,406942,4602	TNF,CXCL12,ERBB4,PRL,KLF2,MIR150,MYB
WP2942	DDX1 as a regulatory component of the Drosha microprocessor	0.930347266677157	-0.0721973575039427	9	7	0.00148399406402374	4717	5310	4683,54487,10111,29102,1653,4361,472	NBN,DGCR8,RAD50,DROSHA,DDX1,MRE11,ATM
WP455	GPCRs, Class A Rhodopsin-like	0.933830377699695	-0.0684604657046779	259	223	0.0472758108967564	4717	5310	2853,4159,10936,5732,81491,4829,29909,1129,2842,1815,53836,2830,886,4888,2834,10161,2149,9283,1133,5734,185,7852,719,4986,4160,5540,146,2832,8111,27202,2844,1236,624,729230,5731,283160,135,1812,2845,26539,5028,4157,4161,10316,4543,94233,8388,8383,3274,26493,8390,26188,2841,1524,623,2358,2835,26476,1814,8590,158131,2826,155,10803,11255,8392,2831,5032,152,3577,4992,144124,3356,643,4886,64805,23596,4994,57121,266747,4988,2847,5737,26707,136,56670,8811,4991,1233,3579,1238,5031,8386,64106,4995,1910,151,11250,3363,6753,442186,2863,26538,553,23432,1269,2587,5739,887,8484,4985,4158,2862,51554,2859,81696,1230,6010,8387,4889,1234,5724,1128,26659,6752,23637,9034,3362,4142,2357,2864,56923,3973,148,2492,2150,147,3360,1240,6915,6754,2693,26696,140,26212,1816,1232,23620,9934,2861,5029,2151,6755,7932,81697,6751,3357,1909,3361,1241,2865,4887,2825,1235,53829,2359,4993,120776,26664,79541,26333,10692,11251,57105,26692,7201,126370,1237,150,3269,1131,8477,3062,57007,154,4544,3351,26658,134,2867,2827,4923,153,116511,3355,1813,9293,3350,5729,3354,56656,187,552,54329,2838,135948,2854,442191,10886,1132,3061,10888,611,3352,2843,4987,2848,5733,390756,5021,2829,2852,1268	GPR31,MC3R,GPR75,PTGER2,GPR63,NMBR,GPR171,CHRM2,GPR19,DRD4,GPR87,GPR6,CCKAR,NPY6R,PRLHR,LPAR6,F2R,GPR37L1,CHRM5,PTGER4,AGTR1,CXCR4,C3AR1,OPRK1,MC4R,NPY4R,ADRA1D,NPBWR2,GPR68,C5AR2,GPR21,CCR7,BDKRB2,CCR2,PTGER1,OR8D2,ADORA2A,DRD1,GPR22,OR10H1,P2RY1,MC1R,MC5R,NMUR1,MTNR1A,OPN4,OR1E2,OR1A1,HRH2,OR8B8,OR1G1,OR1C1,GPR18,CX3CR1,BDKRB1,FPR2,GPR12,OR10J1,DRD3,OR6A2,OR1Q1,CCR10,ADRB3,CCR9,HRH3,OR3A3,NPBWR1,P2RY11,ADRA2C,CXCR1,OR1F1,OR10A5,HTR2A,CXCR5,NPY1R,P2RY12,OPN3,OR3A1,LPAR5,RGL4,OPRM1,MCHR1,PTGFR,OR2J2,ADORA2B,SUCNR1,GALR2,OR1D2,CCR4,CXCR2,ACKR2,P2RY6,OR1D5,NPFFR1,OR3A2,EDNRB,ADRA2B,GPR45,HTR7,SSTR3,OR2J3,GPR39,OR10H2,AVPR1B,GPR161,CNR2,GALR1,PTGIR,CCKBR,GALR3,OPRD1,MC2R,MLNR,ACKR4,GPR35,OR5V1,CCR1,RHO,OR1E1,NPY5R,CCR5,PTAFR,CHRM1,OR7A5,SSTR2,RABGAP1,CCRL2,HTR6,MAS1,FPR1,FFAR1,NMUR2,LHCGR,ADRA1A,FSHR,F2RL1,ADRA1B,HTR4,CMKLR1,TBXA2R,SSTR4,GHSR,OR2T1,ADORA3,OR2B6,DRD5,CCR3,NTSR2,P2RY14,GPR37,P2RY2,F2RL2,SSTR5,OR2H2,OR2B2,SSTR1,HTR2B,EDNRA,HTR5A,LTB4R,FFAR3,NPY2R,CMKLR2,CCR6,P2RY13,FPR3,OR2C1,OR2D2,OR7C1,OR2A4,OR7A17,RRH,PTGDR2,CYSLTR2,OR2W1,TRHR,OR1I1,CCR8,ADRA2A,HRH1,CHRM3,GPR65,HCRTR2,ACKR3,ADRB2,MTNR1B,HTR1B,OR7C2,ADORA1,FFAR2,GPR3,NTSR1,ADRB1,MAS1L,HTR1F,DRD2,GPR52,HTR1A,PTGDR,HTR1E,OR2S2,APLNR,AVPR1A,GPR85,GPR15,OR2F2,GPR32,OR14J1,NPFFR2,CHRM4,HCRTR1,GPR83,OPN1SW,HTR1D,GPR20,OPRL1,GPR25,PTGER3,OR3A4P,OXTR,XCR1,GPER1,CNR1
WP107	Translation Factors	0.934508676012895	-0.0677343680066686	53	44	0.00932796268814925	4717	5310	8890,3692,9451,8894,7458,8668,1937,728689,8666,1915,8669,5610,10209,3646,1984,10605,8661,1974,9669,1967,8892,1977,8665,1981,26986,8664,1965,8667,1938,8893,1936,27102,1975,23277,8891,8662,8637,29904,1917,1983,8672,1978,2107,1979	EIF2B4,EIF6,EIF2AK3,EIF2S2,EIF4H,EIF3I,EEF1G,EIF3CL,EIF3G,EEF1A1,EIF3J,EIF2AK2,EIF1,EIF3E,EIF5A,PAIP1,EIF3A,EIF4A2,EIF5B,EIF2B1,EIF2B2,EIF4E,EIF3F,EIF4G1,PABPC1,EIF3D,EIF2S1,EIF3H,EEF2,EIF2B5,EEF1D,EIF2AK1,EIF4B,CLUH,EIF2B3,EIF3B,EIF4EBP3,EEF2K,EEF1A2,EIF5,EIF4G3,EIF4EBP1,ETF1,EIF4EBP2
WP3877	Simplified Depiction of MYD88 Distinct Input-Output Pathway	0.947327904486432	-0.0541099896713748	19	15	0.00317998728005088	4717	5310	7100,92610,10333,7099,7334,3725,7096,7189,54106,7097,4615,7335,81793,4790,3552	TLR5,TIFA,TLR6,TLR4,UBE2N,JUN,TLR1,TRAF6,TLR9,TLR2,MYD88,UBE2V1,TLR10,NFKB1,IL1A
WP2276	Glial Cell Differentiation	0.94948237097136	-0.0518383155463291	8	6	0.00127199491202035	4717	5310	11076,4155,4099,2596,1267,406989	TPPP,MBP,MAG,GAP43,CNP,MIR206
WP3413	NOTCH1 regulation of human endothelial cell calcification	0.957415661808844	-0.0435176434685353	18	14	0.00296798812804749	4717	5310	2702,1902,3672,249,4256,5327,3714,54567,182,55553,813,10683,2261,7422	GJA5,LPAR1,ITGA1,ALPL,MGP,PLAT,JAG2,DLL4,JAG1,SOX6,CALU,DLL3,FGFR3,VEGFA
WP3408	Evolocumab Mechanism	0.965414453196714	-0.0351977846675691	3	2	0.000423998304006784	4717	5310	3949,255738	LDLR,PCSK9
WP2846	Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation	0.965414453196714	-0.0351977846675691	3	2	0.000423998304006784	4717	5310	255738,3949	PCSK9,LDLR
WP2805	RNA interference	0.965630660928633	-0.0349738564628468	7	5	0.00105999576001696	4717	5310	57510,54487,90459,23405,29102	XPO5,DGCR8,ERI1,DICER1,DROSHA
WP325	Triacylglyceride Synthesis	0.979359039847036	-0.0208569622680341	26	20	0.00423998304006784	4717	5310	4023,80168,8612,3991,2819,57104,8513,3990,8611,57678,56894,56895,346606,84649,2712,8540,8443,55326,8613,116255	LPL,MOGAT2,PLPP2,LIPE,GPD1,PNPLA2,LIPF,LIPC,PLPP1,GPAM,AGPAT3,AGPAT4,MOGAT3,DGAT2,GK2,AGPS,GNPAT,AGPAT5,PLPP3,MOGAT1
WP411	mRNA Processing	0.980744723822758	-0.019443073644129	132	110	0.0233199067203731	4717	5310	1659,6431,6729,2521,6426,1653,1479,6637,3191,10147,51690,5496,7307,5681,3276,84844,4809,83443,57396,10151,6627,1660,8683,10772,6733,55660,57819,51692,10421,100616459,3187,23283,6421,1196,8106,11218,5094,10658,6432,22916,6633,1665,3192,6829,6430,6434,10978,10914,6629,9410,6628,1195,24148,8405,3190,10482,4904,3178,5725,9343,3183,58155,10181,6429,4686,23405,22803,10907,51362,6428,8732,9584,8559,10992,140890,3184,407043,56853,6433,5430,6625,8449,1198,57794,56339,6732,10946,3181,11338,84991,10291,6636,4670,22826,10236,53981,8731,11129,10262,10594,10972,10250,6626,23451,9129,10898,8899,10659,9128,6635	DHX8,SRSF6,SRP54,FUS,SRSF1,DDX1,CSTF3,SNRPG,HNRNPL,SUGP2,LSM7,PPM1G,U2AF1,PSKH1,PRMT1,PHF5A,SNU13,SF3B5,CLK4,HNRNPA3P1,SNRPA1,DHX9,SRSF9,SRSF10,SRPK2,PRPF40A,LSM2,CPSF3,CD2BP2,MIR4745,HNRNPH1,CSTF2T,SFPQ,CLK2,PABPN1,DDX20,PCBP2,CELF1,SRSF7,NCBP2,SNRPD2,DHX15,HNRNPU,SUPT5H,SRSF5,TRA2B,CLP1,PAPOLA,SNRPB2,SNRNP40,SNRPB,CLK1,PRPF6,SPOP,HNRNPK,NXF1,YBX1,HNRNPA1,PTBP1,EFTUD2,HNRNPC,PTBP2,RBM5,SRSF4,NCBP1,DICER1,XRN2,TXNL4A,CDC40,SRSF3,RNGTT,RBM39,PRPF18,SF3B2,SREK1,HNRNPD,MIR7-1,CELF4,SFSWAP,POLR2A,SNRNP70,DHX16,CLK3,SUGP1,METTL3,SRPK1,SF3A3,HNRNPA2B1,U2AF2,RBM17,SF3A1,SNRPF,HNRNPM,DNAJC8,HNRNPR,CPSF2,RNMT,CLASRP,SF3B4,PRPF8,TMED10,SRRM1,SNRPA,SF3B1,PRPF3,CPSF4,PRP4K,CELF2,PRPF4,SNRPE
WP1992	TarBasePathway	0.985661382283012	-0.0144424090400627	19	14	0.00296798812804749	4717	5310	58155,3759,3479,442890,10021,3753,610,2697,9464,406923,6722,3784,9759,2078	PTBP2,KCNJ2,IGF1,MIR133B,HCN4,KCNE1,HCN2,GJA1,HAND2,MIR133A2,SRF,KCNQ1,HDAC4,ERG
WP22	IL-9 Signaling Pathway	0.985661382283012	-0.0144424090400627	19	14	0.00296798812804749	4717	5310	3716,5295,3718,6774,5604,5296,6772,5595,6776,5605,3578,5594,6777,2885	JAK1,PIK3R1,JAK3,STAT3,MAP2K1,PIK3R2,STAT1,MAPK3,STAT5A,MAP2K2,IL9,MAPK1,STAT5B,GRB2
WP404	Nucleotide Metabolism	0.985661382283012	-0.0144424090400627	19	14	0.00296798812804749	4717	5310	50484,5424,158,6723,10797,1719,4831,4946,5428,5423,3614,159,6240,6241	RRM2B,POLD1,ADSL,SRM,MTHFD2,DHFR,NME2,OAZ1,POLG,POLB,IMPDH1,ADSS2,RRM1,RRM2
WP1438	Influenza A virus infection	0.987547138619485	-0.0125310480352834	2	1	0.000211999152003392	4717	5310	596	BCL2
WP2816	Felbamate Metabolism	0.987547138619485	-0.0125310480352834	2	1	0.000211999152003392	4717	5310	1576	CYP3A4
WP2338	miRNA Biogenesis	0.992544477503469	-0.0074834538193812	8	5	0.00105999576001696	4717	5310	23405,29102,5901,57510,54487	DICER1,DROSHA,RAN,XPO5,DGCR8
WP2029	Cell Differentiation - Index	0.992756135894819	-0.0072702282849465	38	29	0.00614797540809837	4717	5310	4208,3195,442890,574447,4209,406986,574457,6774,406942,7044,10637,100616357,100422842,406955,10014,406995,4205,406915,3196,100271849,406957,406954,406951,4654,406976,6722,30012,407046,406956	MEF2C,TLX1,MIR133B,MIR146B,MEF2D,MIR203A,MIR181D,STAT3,MIR150,LEFTY2,LEFTY1,MIR3591,MIR3074,MIR181B1,HDAC5,MIR181A1,MEF2A,MIR128-1,TLX2,MEF2B,MIR181C,MIR181A2,MIR16-2,MYOD1,MIR199A1,SRF,TLX3,MIR9-1,MIR181B2
WP2059	Alzheimers Disease	0.993579789412524	-0.00644090877819299	148	122	0.0258638965444138	4717	5310	2597,3553,407051,5330,488,693183,487,100302174,100126333,406917,8883,406955,406893,407047,823,102,5532,805,54480,5332,7124,2776,5530,355,768217,5534,406908,824,22926,7132,406991,407046,7157,406956,8851,5535,6263,3710,100422912,23385,100423037,776,407032,6868,5664,406954,836,4035,5331,348,2903,157627,442900,574453,317,11261,51806,51107,81671,54205,23236,841,23621,100126348,406930,406907,801,322,5663,254559,8772,2081,406995,407001,779,3416,9451,351,442897,406918,4137,407000,2932,775,406958,6622,645323,4311,406931,5595,494326,768213,407021,2904,406929,2905,3709,4842,494330,5594,3708,808,4023,406911,810,840,489,842,100126343,406924,5533,693120,574441,2906,406909,100126316,406926,63928,406960,574457,1020,100506742	GAPDH,IL1B,MIR9-3,PLCB2,ATP2A2,MIR598,ATP2A1,MIR1307,MIR708,MIR129-1,NAE1,MIR181B1,MIR101-1,MIR9-2,CAPN1,ADAM10,PPP3CB,CALM2,CHPF2,PLCB4,TNF,GNAQ,PPP3CA,FAS,MIR769,PPP3R1,MIR124-2,CAPN2,ATF6,TNFRSF1A,MIR21,MIR9-1,TP53,MIR181B2,CDK5R1,PPP3R2,RYR3,ITPR3,MIR3200,NCSTN,MIR3176,CACNA1D,MIR30C2,ADAM17,PSEN2,MIR181A2,CASP3,LRP1,PLCB3,APOE,GRIN2A,MIR124-1HG,MIR326,MIR495,APAF1,CHP1,CALML5,APH1A,VMP1,CYCS,PLCB1,CASP8,BACE1,MIR760,MIR138-2,MIR124-1,CALM1,APBB1,PSEN1,MIR9-3HG,FADD,ERN1,MIR181A1,MIR218-2,CACNA1S,IDE,EIF2AK3,APP,MIR323A,MIR129-2,MAPT,MIR218-1,GSK3B,CACNA1C,MIR182,SNCA,MIR9-2HG,MME,MIR139,MAPK3,MIR377,MIR671,MIR29A,GRIN2B,MIR138-1,GRIN2C,ITPR2,NOS1,MIR381,MAPK1,ITPR1,CALM3,LPL,MIR125B1,CALML3,CASP7,ATP2A3,CASP9,MIR874,MIR134,PPP3CC,MIR33B,MIR488,GRIN2D,MIR124-3,MIR873,MIR135A2,CHP2,MIR184,MIR181D,CDK5,CASP12
WP2911	miRNA targets in ECM and membrane receptors	0.993767762578832	-0.00625173888017438	43	33	0.00699597201611194	4717	5310	406984,6383,407034,2335,3915,3693,7148,406985,406933,442892,407033,1282,693174,407031,1281,100500837,3694,22801,3913,1290,1289,50509,554210,3672,1278,407030,7057,3910,7058,1293,1284,407032,406901	MIR200B,SDC2,MIR30E,FN1,LAMC1,ITGB5,TNXB,MIR200C,MIR141,MIR148B,MIR30D,COL4A1,MIR589,MIR30C1,COL3A1,MIR3606,ITGB6,ITGA11,LAMB2,COL5A2,COL5A1,COL5A3,MIR429,ITGA1,COL1A2,MIR30B,THBS1,LAMA4,THBS2,COL6A3,COL4A2,MIR30C2,MIR107
WP1530	miRNA Regulation of DNA Damage Response	0.993840373335946	-0.00617867542683602	93	75	0.0158999364002544	4717	5310	896,10111,672,841,84126,993,8795,5810,1021,4193,1647,1385,5888,406995,5883,898,894,5981,5925,545,5591,25,442918,9134,1026,10912,4609,4683,166979,11200,1017,355,983,11011,1869,7157,5893,995,5884,406980,5371,407975,842,836,2810,1643,1111,891,1027,135458,5366,900,100422842,100616357,55367,27113,554213,63970,27244,406992,581,54205,406986,1019,9133,4616,1020,50484,595,2177,317,4361,472,9874,6118	CCND3,RAD50,BRCA1,CASP8,ATRIP,CDC25A,TNFRSF10B,RAD1,CDK6,MDM2,GADD45A,CREB1,RAD51,MIR181A1,RAD9A,CCNE1,CCND2,RFC1,RB1,ATR,PRKDC,ABL1,MIR373,CCNE2,CDKN1A,GADD45G,MYC,NBN,CDC20B,CHEK2,CDK2,FAS,CDK1,TLK2,E2F1,TP53,RAD52,CDC25C,RAD17,MIR19B1,PML,MIR17HG,CASP9,CASP3,SFN,DDB2,CHEK1,CCNB1,CDKN1B,HUS1B,PMAIP1,CCNG1,MIR3074,MIR3591,PIDD1,BBC3,MIR449A,TP53AIP1,SESN1,MIR210,BAX,CYCS,MIR203A,CDK4,CCNB2,GADD45B,CDK5,RRM2B,CCND1,FANCD2,APAF1,MRE11,ATM,TLK1,RPA2
WP2249	Metastatic brain tumor	0.997520251588166	-0.00248282808018271	28	20	0.00423998304006784	4717	5310	407021,406881,1021,406893,406890,100616143,400931,406882,5295,406894,406940,407026,406885,7157,1871,406883,998,406884,4609,442892	MIR29A,MIRLET7A1,CDK6,MIR101-1,MIRLET7G,MIR4763,MIRLET7BHG,MIRLET7A2,PIK3R1,MIR101-2,MIR148A,MIR29C,MIRLET7C,TP53,E2F3,MIRLET7A3,CDC42,MIRLET7B,MYC,MIR148B
WP477	Cytoplasmic Ribosomal Proteins	0.999294224077681	-0.000706025099394659	90	70	0.0148399406402374	4717	5310	4736,6160,6124,6164,6155,6201,6233,23521,6196,25873,6205,6167,6198,6144,6199,9045,6156,6235,6137,6122,6159,6217,9349,6142,6209,6223,6228,6210,6206,6229,6195,6231,6130,11224,6208,6135,6189,6202,6194,6188,6176,6143,6146,6123,6128,6168,6169,6230,6234,6129,3921,6152,6161,6139,6157,6224,6175,6138,6133,6204,6136,6232,7311,6154,6227,6181,6125,9801,6207,6165	RPL10A,RPL31,RPL4,RPL34,RPL27,RPS7,RPS27A,RPL13A,RPS6KA2,RPL36,RPS11,RPL37,RPS6KB1,RPL21,RPS6KB2,RPL14,RPL30,RPS29,RPL13,RPL3,RPL29,RPS16,RPL23,RPL18A,RPS15,RPS19,RPS23,RPS15A,RPS12,RPS24,RPS6KA1,RPS26,RPL7A,RPL35,RPS14,RPL11,RPS3A,RPS8,RPS6,RPS3,RPLP1,RPL19,RPL22,RPL3L,RPL6,RPL37A,RPL38,RPS25,RPS28,RPL7,RPSA,RPL24,RPL32,RPL17,RPL27A,RPS20,RPLP0,RPL15,RPL9,RPS10,RPL12,RPS27,UBA52,RPL26,RPS21,RPLP2,RPL5,MRPL19,RPS13,RPL35A
WP3627	Gut-Liver Indole Metabolism	1.00000000000951	9.51416723182774e-12	1	0	0	4717	5310
WP1545	miRNAs involved in DNA damage response	1.00000000002724	2.72366569402382e-11	50	25	0.0052999788000848	4717	5310	554213,406992,4609,1027,406892,25,100422842,442918,1026,472,406881,406986,595,993,1869,896,7157,5893,407011,1385,406995,898,406955,1021,442917	MIR449A,MIR210,MYC,CDKN1B,MIR100,ABL1,MIR3074,MIR373,CDKN1A,ATM,MIRLET7A1,MIR203A,CCND1,CDC25A,E2F1,CCND3,TP53,RAD52,MIR23B,CREB1,MIR181A1,CCNE1,MIR181B1,CDK6,MIR372
WP2371	Parkinsons Disease Pathway	1.00000000002759	2.75938145962817e-11	83	51	0.010811956752173	4717	5310	407034,6300,7314,2861,7326,1432,9627,54205,406890,317,120892,100126316,11315,7054,2058,5071,65018,406951,407975,406980,406916,836,407015,6311,842,118424,100187716,442906,7345,407017,5600,840,6622,51465,835,9134,100847079,7327,7332,9246,7318,6531,1644,5603,407016,407029,406915,839,898,27429,23208	MIR30E,MAPK12,UBB,GPR37,UBE2G1,MAPK14,SNCAIP,CYCS,MIRLET7G,APAF1,LRRK2,MIR873,PARK7,TH,EPRS1,PRKN,PINK1,MIR16-2,MIR17HG,MIR19B1,MIR128-2,CASP3,MIR26A1,ATXN2,CASP9,UBE2J2,MIR1224,MIR338,UCHL1,MIR26B,MAPK11,CASP7,SNCA,UBE2J1,CASP2,CCNE2,MIR5193,UBE2G2,UBE2L3,UBE2L6,UBA7,SLC6A3,DDC,MAPK13,MIR26A2,MIR30A,MIR128-1,CASP6,CCNE1,HTRA2,SYT11