TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
R-HSA-1474244	Extracellular matrix organization	0.00014137185055566	-8.86411690101284	296	279	0.0308833296435687	9034	10285	1280,85007,55214,10536,92291,1296,1308,3675,50509,63827,2006,22795,4314,170692,652,3676,1295,1277,999,100126326,9378,5340,3685,1462,634,10319,4326,1515,50848,3384,1310,3915,5802,836,4236,4325,3818,10516,8076,3690,5154,84467,8516,3912,4322,255631,1215,667,7412,3383,831,4680,9507,8515,9313,7043,3371,3682,63923,1834,5175,1504,340267,4811,1991,85301,1404,6696,4313,650,3672,2200,3381,1278,4323,3791,3913,3655,2243,147968,1513,1758,1307,3683,7177,100313843,7042,780,1293,1511,1300,3681,5339,1634,9509,3817,649,5118,3673,100616237,4321,8425,84290,7148,84695,3911,4312,823,1294,10753,9508,1289,825,4015,11095,5650,54829,79709,11131,3674,6650,4316,102,4016,3386,283208,5155,4324,91522,1463,3914,23473,83700,7373,2244,4038,824,1514,4146,3385,3684,100616340,440387,9510,388743,2199,5663,6678,726,4921,164656,3910,4320,4593,7276,3695,9672,26254,682,5578,10893,81578,3680,961,5644,3696,5045,1301,23127,1297,5654,440854,1508,136227,4237,6383,7092,1286,3687,1303,1290,8174,2247,22801,2335,6868,4319,655,3908,1285,4327,2202,8974,1282,59277,1605,1509,977,100500837,5352,30008,4318,7077,3909,256076,58494,84570,26577,5479,4052,7087,2192,4148,170690,1306,3691,1298,50859,140766,960,871,64386,5034,1311,56999,176,1305,7143,8200,4060,6385,4053,169044,8754,375790,5351,3918,2266,10491,3693,27302,1281,3688,64175,4238,4684,8985,2331,2201,4054,23385,11096,4317,4017,8785,3694,3339,7057,4239,7040,3689,2,284217,1302,1284,131873,87,7093,6382,100422894,1520,5033,1299,84171,1088,8751,57642,5054,3679	COL2A1,PHYKPL,P3H2,P3H3,CAPN13,COL8A2,COL17A1,ITGA3,COL5A3,BCAN,ELN,NID2,MMP3,ADAMTS18,BMP4,ITGA4,COL8A1,COL1A1,CDH1,MIR936,NRXN1,PLG,ITGAV,VCAN,CEACAM1,LAMC3,MMP17,CTSV,F11R,ICAM2,COL19A1,LAMC1,PTPRS,CASP3,MFAP1,MMP16,KLKB1,FBLN5,MFAP5,ITGB3,PDGFA,FBN3,ITGA8,LAMB1,MMP13,COL24A1,CMA1,DST,VCAM1,ICAM1,CAST,CEACAM6,ADAMTS4,ITGA10,MMP20,TGFB3,TNC,ITGAE,TNN,DSPP,PECAM1,CTRB1,COL28A1,NID1,ELANE,COL27A1,HAPLN1,SPP1,MMP2,BMP2,ITGA1,FBN1,IBSP,COL1A2,MMP14,KDR,LAMB2,ITGA6,FGA,CAPN12,CTSK,DMP1,COL16A1,ITGAL,TPSAB1,MIR711,TGFB2,DDR1,COL6A3,CTSG,COL10A1,ITGAD,PLEC,DCN,ADAMTS2,KLK2,BMP1,PCOLCE,ITGA2,MIR4640,MMP12,LTBP4,CAPNS2,TNXB,LOXL3,LAMA5,MMP1,CAPN1,COL7A1,CAPN9,ADAMTS3,COL5A1,CAPN3,LOX,ADAMTS8,KLK7,ASPN,COLGALT1,CAPN11,ITGA2B,CAPN15,MMP7,ADAM10,LOXL1,ICAM4,P4HA3,PDGFB,MMP15,COL23A1,NCAN,LAMB3,CAPN7,JAM3,COL14A1,FGB,LRP4,CAPN2,CTSL,MATN1,ICAM3,ITGAM,MIR4758,CTRB2,ADAMTS1,CAPN8,FBLN2,PSEN1,SPARC,CAPN5,DDR2,TMPRSS6,LAMA4,MMP11,MUSK,TTR,ITGB7,SDC3,OPTC,BSG,PRKCA,MMP24,COL21A1,ITGA9,CD47,PRSS1,ITGB8,FURIN,COL11A1,COLGALT2,COL9A1,HTRA1,CAPN14,CTSB,COL26A1,MFAP2,SDC2,TLL1,COL4A4,ITGAX,COL12A1,COL5A2,MADCAM1,FGF2,ITGA11,FN1,ADAM17,MMP10,BMP7,LAMA2,COL4A3,MMP19,EFEMP1,P4HA2,COL4A1,NTN4,DAG1,CTSD,CD151,MIR3606,PLOD2,EFEMP2,MMP9,TIMP2,LAMA3,COL6A5,JAM2,COL25A1,PCOLCE2,PPIB,LTBP1,ICAM5,FBLN1,MATN3,ADAMTS16,COL15A1,ITGB4,COL9A2,SPOCK3,ADAMTS14,CD44,SERPINH1,MMP25,P4HB,COMP,ADAMTS9,ACAN,COL13A1,TNR,GDF5,LUM,SDC4,LTBP2,COL22A1,ADAM9,AGRN,PLOD1,LAMC2,FGG,CRTAP,ITGB5,BMP10,COL3A1,ITGB1,P3H1,MFAP3,NCAM1,PLOD3,FMOD,FBN2,LTBP3,NCSTN,ADAMTS5,MMP8,LOXL2,MATN4,ITGB6,HSPG2,THBS1,MFAP4,TGFB1,ITGB2,A2M,LAMA1,COL11A2,COL4A2,COL6A6,ACTN1,TLL2,SDC1,MIR4260,CTSS,P4HA1,COL9A3,LOXL4,CEACAM8,ADAM15,COL20A1,SERPINE1,ITGA7
R-HSA-418555	G alpha (s) signalling events	0.000191327459529793	-8.56152415010569	146	141	0.0156077042284702	9034	10285	53831,2691,122876,408,3362,2791,10268,2771,2740,5443,10888,2783,10266,2778,5136,11245,3640,1394,2838,2492,50940,133,116,2781,196883,409,117,2854,6343,153,2788,134864,2793,2773,5142,27115,3375,155,2642,5746,5150,9038,9287,3360,2870,4157,51764,6344,3973,5745,729966,11250,2848,10846,799,797,113091,551,94235,1081,796,346562,135,5732,2784,4161,2843,5140,7432,111,7252,154,406974,3972,59350,112,170589,5744,6019,10267,2695,594857,114,83551,5144,5138,2696,9340,387129,1816,115,2787,285601,2869,7253,7433,8622,1392,5032,2790,2770,4159,2641,151306,5729,2786,5734,157,10681,1395,59345,5141,10203,1812,3363,5153,4160,108,3274,2488,4158,7434,113,319100,9288,136,5741,117579,2782,107,109,54331,55970,5739,122042,5139,5143,156,2792,5151,2692	GPR84,GHRH,GPHB5,ARRB1,HTR6,GNG11,RAMP3,GNAI2,GLP1R,POMC,GPR83,GNB2,RAMP2,GNAS,PDE1A,GPR176,INSL3,CRHR1,GPR15,FSHR,PDE11A,ADM,ADCYAP1,GNAZ,ADCY4,ARRB2,ADCYAP1R1,GPR32,SCT,ADRB1,GNG7,TAAR1,GNGT2,GNAI3,PDE4B,PDE7B,IAPP,ADRB3,GCGR,PTH2R,PDE7A,TAAR5,TAAR2,HTR4,GRK6,MC1R,GNG13,SCTR,LHCGR,PTH1R,CIST1,GPR45,GPR25,PDE10A,CALCR,CALCB,PTH2,AVP,GNG8,CGA,CALCA,GNAT3,ADORA2A,PTGER2,GNB3,MC5R,GPR20,PDE3B,VIP,ADCY5,TSHB,ADRB2,MIR197,LHB,RXFP1,ADCY6,GPHA2,PTHLH,RLN2,RAMP1,GIP,NPS,ADCY8,TAAR8,PDE4D,PDE2A,GIPR,GLP2R,NPSR1,DRD5,ADCY9,GNG5,GPR150,GRK5,TSHR,VIPR1,PDE8B,CRH,P2RY11,GNG10,GNAI1,MC3R,GCG,GPBAR1,PTGDR,GNG4,PTGER4,GRK3,GNB5,CRHR2,GNB4,PDE4A,CALCRL,DRD1,HTR7,PDE1B,MC4R,ADCY2,HRH2,FSHB,MC2R,VIPR2,ADCY7,TAAR6,TAAR3P,ADORA2B,PTH,RLN3,GNB1,ADCY1,ADCY3,GNG2,GNG12,PTGIR,RXFP2,PDE3A,PDE4C,GRK2,GNGT1,PDE8A,GHRHR
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization	0.00021391659905681	-8.44992434293817	131	127	0.0140580030994023	9034	10285	23035,2254,5781,23239,5290,5529,8822,5515,64223,2885,2534,57761,2249,3630,5516,208,27161,1027,8394,8660,8074,2309,2065,2932,5156,941,2475,29851,5296,3164,1026,3932,5155,4193,2066,6714,50852,207,5295,842,2308,4343,4233,3082,79837,2251,79109,9365,192670,27006,26281,2260,6199,4254,10818,5595,118788,5528,2253,3815,23396,2549,10718,2248,4067,5293,10000,5594,7249,5170,1950,930,7409,9542,8817,55615,5728,5518,57690,23112,1385,1839,1956,26523,2252,8503,5291,2264,5305,27327,940,6464,7157,192669,5159,2263,2069,2931,2255,942,3643,9846,685,2261,2247,84335,5154,9965,2250,8396,8870,6654,3667,5526,2246,145957,2064,6850,253260,117145,5519,5525,7462,8395,5527,3084,1147	PHLPP2,FGF9,PTPN11,PHLPP1,PIK3CA,PPP2R5E,FGF17,PPP2CA,MLST8,GRB2,FYN,TRIB3,FGF4,INS,PPP2CB,AKT2,AGO2,CDKN1B,PIP5K1A,IRS2,FGF23,FOXO3,ERBB3,GSK3B,PDGFRA,CD80,MTOR,ICOS,PIK3R2,NR4A1,CDKN1A,LCK,PDGFB,MDM2,ERBB4,SRC,TRAT1,AKT1,PIK3R1,CASP9,FOXO1,MOV10,MET,HGF,PIP4K2C,FGF6,MAPKAP1,KL,AGO4,FGF22,FGF20,FGFR1,RPS6KB2,KITLG,FRS2,MAPK3,PIK3AP1,PPP2R5D,FGF8,KIT,PIP5K1C,GAB1,NRG3,FGF3,LYN,PIK3CD,AKT3,MAPK1,TSC2,PDPK1,EGF,CD19,VAV1,NRG2,FGF18,PRR5,PTEN,PPP2R1A,TNRC6C,TNRC6B,CREB1,HBEGF,EGFR,AGO1,FGF7,PIK3R3,PIK3CB,FGFR4,PIP4K2A,TNRC6A,CD28,SHC1,TP53,AGO3,PDGFRB,FGFR2,EREG,GSK3A,FGF10,CD86,INSR,GAB2,BTC,FGFR3,FGF2,AKT1S1,PDGFA,FGF19,FGF5,PIP4K2B,IER3,SOS1,IRS1,PPP2R5B,FGF1,NRG4,ERBB2,SYK,RICTOR,THEM4,PPP2R1B,PPP2R5A,LAT2,PIP5K1B,PPP2R5C,NRG1,CHUK
R-HSA-198203	PI3K/AKT activation	0.000290266915398914	-8.14470966036292	128	124	0.0137259242860306	9034	10285	118788,5528,2253,2248,10718,3815,4914,2549,23396,2308,842,4343,4233,26281,9365,192670,27006,10818,5595,4254,6199,2260,79837,3082,79109,2251,29851,941,2475,3164,5296,8660,8394,27161,1027,5156,2932,2065,8074,2309,207,6714,50852,5295,3932,1026,2066,4193,5155,23239,387,5529,5515,8822,5290,23035,5781,2254,3630,208,5516,4803,2885,64223,2249,57761,2534,2250,9965,5154,5526,3667,8396,8870,685,2261,84335,2247,117145,253260,2064,145957,1147,3084,5527,8395,5519,5525,2246,7157,5159,192669,3643,942,2255,2931,2263,2069,2252,26523,8503,23112,1385,1956,1839,940,5291,5305,2264,27327,7409,55615,9542,8817,5293,5594,10000,1950,930,5170,7249,57690,5728,5518	PIK3AP1,PPP2R5D,FGF8,FGF3,NRG3,KIT,NTRK1,GAB1,PIP5K1C,FOXO1,CASP9,MOV10,MET,FGF20,KL,AGO4,FGF22,FRS2,MAPK3,KITLG,RPS6KB2,FGFR1,PIP4K2C,HGF,MAPKAP1,FGF6,ICOS,CD80,MTOR,NR4A1,PIK3R2,IRS2,PIP5K1A,AGO2,CDKN1B,PDGFRA,GSK3B,ERBB3,FGF23,FOXO3,AKT1,SRC,TRAT1,PIK3R1,LCK,CDKN1A,ERBB4,MDM2,PDGFB,PHLPP1,RHOA,PPP2R5E,PPP2CA,FGF17,PIK3CA,PHLPP2,PTPN11,FGF9,INS,AKT2,PPP2CB,NGF,GRB2,MLST8,FGF4,TRIB3,FYN,FGF5,FGF19,PDGFA,PPP2R5B,IRS1,PIP4K2B,IER3,BTC,FGFR3,AKT1S1,FGF2,THEM4,RICTOR,ERBB2,NRG4,CHUK,NRG1,PPP2R5C,PIP5K1B,PPP2R1B,PPP2R5A,FGF1,TP53,PDGFRB,AGO3,INSR,CD86,FGF10,GSK3A,FGFR2,EREG,FGF7,AGO1,PIK3R3,TNRC6B,CREB1,EGFR,HBEGF,CD28,PIK3CB,PIP4K2A,FGFR4,TNRC6A,VAV1,PRR5,NRG2,FGF18,PIK3CD,MAPK1,AKT3,EGF,CD19,PDPK1,TSC2,TNRC6C,PTEN,PPP2R1A
R-HSA-180292	GAB1 signalosome	0.000290266915398914	-8.14470966036292	128	124	0.0137259242860306	9034	10285	57690,5728,5518,55615,9542,8817,7409,930,1950,7249,5170,5594,10000,5293,940,27327,2264,5291,5305,8503,2252,26523,55824,1839,1956,1385,23112,942,3643,2931,2255,2069,2263,192669,5159,7157,3084,5527,1147,8395,5519,5525,253260,117145,145957,2064,2246,3667,5526,8870,8396,2250,5154,9965,2247,84335,685,2261,5516,208,3630,2249,2534,57761,64223,2885,8822,5529,5515,5290,23239,1445,5781,2254,23035,5829,5295,207,6714,50852,2066,5155,4193,3932,1026,3164,5296,29851,941,2475,2932,5156,2309,8074,2065,8394,8660,1027,27161,4254,5595,10818,2260,6199,26281,27006,192670,9365,79109,2251,79837,3082,4343,4233,842,2308,2248,10718,2549,23396,3815,2253,118788,5528	TNRC6C,PTEN,PPP2R1A,PRR5,NRG2,FGF18,VAV1,CD19,EGF,TSC2,PDPK1,MAPK1,AKT3,PIK3CD,CD28,TNRC6A,FGFR4,PIK3CB,PIP4K2A,PIK3R3,FGF7,AGO1,PAG1,HBEGF,EGFR,CREB1,TNRC6B,CD86,INSR,GSK3A,FGF10,EREG,FGFR2,AGO3,PDGFRB,TP53,NRG1,PPP2R5C,CHUK,PIP5K1B,PPP2R1B,PPP2R5A,RICTOR,THEM4,NRG4,ERBB2,FGF1,IRS1,PPP2R5B,IER3,PIP4K2B,FGF5,PDGFA,FGF19,FGF2,AKT1S1,BTC,FGFR3,PPP2CB,AKT2,INS,FGF4,FYN,TRIB3,MLST8,GRB2,FGF17,PPP2R5E,PPP2CA,PIK3CA,PHLPP1,CSK,PTPN11,FGF9,PHLPP2,PXN,PIK3R1,AKT1,SRC,TRAT1,ERBB4,PDGFB,MDM2,LCK,CDKN1A,NR4A1,PIK3R2,ICOS,CD80,MTOR,GSK3B,PDGFRA,FOXO3,FGF23,ERBB3,PIP5K1A,IRS2,CDKN1B,AGO2,KITLG,MAPK3,FRS2,FGFR1,RPS6KB2,FGF20,FGF22,AGO4,KL,MAPKAP1,FGF6,PIP4K2C,HGF,MOV10,MET,CASP9,FOXO1,FGF3,NRG3,GAB1,PIP5K1C,KIT,FGF8,PIK3AP1,PPP2R5D
R-HSA-1257604	PIP3 activates AKT signaling	0.000393053559867747	-7.84156467073017	125	121	0.0133938454726588	9034	10285	2248,10718,2549,23396,3815,2253,5528,118788,4254,5595,10818,2260,6199,26281,9365,27006,192670,79109,2251,79837,3082,4233,4343,842,2308,5295,207,6714,50852,2066,5155,4193,3932,1026,3164,5296,29851,2475,941,2932,5156,8074,2309,2065,8394,8660,1027,27161,208,5516,3630,2249,2534,57761,64223,2885,5529,8822,5515,5290,23239,5781,2254,23035,8395,1147,3084,5527,5519,5525,117145,253260,145957,2064,2246,3667,5526,8870,8396,2250,5154,9965,2247,84335,2261,685,942,3643,2931,2255,2069,2263,192669,5159,7157,940,27327,2264,5291,5305,8503,2252,26523,1839,1956,1385,23112,57690,5728,5518,55615,8817,9542,7409,930,1950,7249,5170,5594,10000,5293	FGF3,NRG3,GAB1,PIP5K1C,KIT,FGF8,PPP2R5D,PIK3AP1,KITLG,MAPK3,FRS2,FGFR1,RPS6KB2,FGF20,KL,FGF22,AGO4,MAPKAP1,FGF6,PIP4K2C,HGF,MET,MOV10,CASP9,FOXO1,PIK3R1,AKT1,SRC,TRAT1,ERBB4,PDGFB,MDM2,LCK,CDKN1A,NR4A1,PIK3R2,ICOS,MTOR,CD80,GSK3B,PDGFRA,FGF23,FOXO3,ERBB3,PIP5K1A,IRS2,CDKN1B,AGO2,AKT2,PPP2CB,INS,FGF4,FYN,TRIB3,MLST8,GRB2,PPP2R5E,FGF17,PPP2CA,PIK3CA,PHLPP1,PTPN11,FGF9,PHLPP2,PIP5K1B,CHUK,NRG1,PPP2R5C,PPP2R1B,PPP2R5A,THEM4,RICTOR,NRG4,ERBB2,FGF1,IRS1,PPP2R5B,IER3,PIP4K2B,FGF5,PDGFA,FGF19,FGF2,AKT1S1,FGFR3,BTC,CD86,INSR,GSK3A,FGF10,EREG,FGFR2,AGO3,PDGFRB,TP53,CD28,TNRC6A,FGFR4,PIK3CB,PIP4K2A,PIK3R3,FGF7,AGO1,HBEGF,EGFR,CREB1,TNRC6B,TNRC6C,PTEN,PPP2R1A,PRR5,FGF18,NRG2,VAV1,CD19,EGF,TSC2,PDPK1,MAPK1,AKT3,PIK3CD
R-HSA-199418	Negative regulation of the PI3K/AKT network	0.000476708077846552	-7.64860625055083	94	92	0.0101837502767323	9034	10285	941,29851,5296,8394,8660,8074,2065,5156,6714,50852,207,5295,3932,5155,2066,23239,5290,5515,5529,8822,23035,2254,5781,3630,5516,208,2885,2534,57761,2249,5528,118788,2253,10718,2248,3815,23396,2549,4233,9365,27006,26281,2260,4254,10818,5595,3082,79837,2251,2252,8503,1839,1956,940,5291,5305,2264,7409,9542,8817,5293,5594,10000,930,1950,5518,5728,5154,9965,2250,8870,8396,3667,5526,685,2261,2247,145957,2064,117145,5525,5519,3084,8395,5527,2246,5159,2255,942,3643,2263,2069	CD80,ICOS,PIK3R2,PIP5K1A,IRS2,FGF23,ERBB3,PDGFRA,SRC,TRAT1,AKT1,PIK3R1,LCK,PDGFB,ERBB4,PHLPP1,PIK3CA,PPP2CA,PPP2R5E,FGF17,PHLPP2,FGF9,PTPN11,INS,PPP2CB,AKT2,GRB2,FYN,TRIB3,FGF4,PPP2R5D,PIK3AP1,FGF8,NRG3,FGF3,KIT,PIP5K1C,GAB1,MET,KL,FGF22,FGF20,FGFR1,KITLG,FRS2,MAPK3,HGF,PIP4K2C,FGF6,FGF7,PIK3R3,HBEGF,EGFR,CD28,PIK3CB,PIP4K2A,FGFR4,VAV1,NRG2,FGF18,PIK3CD,MAPK1,AKT3,CD19,EGF,PPP2R1A,PTEN,PDGFA,FGF19,FGF5,IER3,PIP4K2B,IRS1,PPP2R5B,BTC,FGFR3,FGF2,NRG4,ERBB2,THEM4,PPP2R5A,PPP2R1B,NRG1,PIP5K1B,PPP2R5C,FGF1,PDGFRB,FGF10,CD86,INSR,FGFR2,EREG
R-HSA-177929	Signaling by EGFR	0.000541012671943381	-7.52206785620656	364	339	0.0375249059110029	9034	10285	9048,1437,4233,5576,408,8027,27006,192670,9365,2243,5700,5575,4254,3559,6199,2260,79837,3082,5136,25780,2251,28956,3562,5567,5605,6233,5707,196883,5718,5528,2253,3265,29924,5774,8682,84078,23396,5694,1846,5582,7450,9693,102,23239,5529,5719,5290,8874,5781,2254,64096,100847012,9146,3674,208,817,57761,2534,5693,29851,941,2475,3164,54756,8660,1027,5156,2932,2065,27040,5691,8074,207,25759,11221,2244,5720,3558,8437,7414,818,2066,5155,10125,5710,143471,7157,88,23198,7979,192669,1844,6456,3643,942,5692,2255,2931,4893,122706,6710,6455,114,115,3690,6708,283455,10048,5154,3667,685,5573,7010,84335,117145,2064,5782,5527,1147,3084,5717,5519,5708,115727,2246,9861,5568,53358,5581,5153,5894,10254,55615,5687,8817,9542,801,5245,1950,6709,7249,5037,113,5786,3716,5908,3845,815,51332,5518,5728,2252,109,5695,8503,814,284,23112,8831,1385,1843,5696,57731,1439,940,5536,5305,5623,5604,5580,10252,2308,153090,842,4343,4902,9978,152559,10256,5713,5137,64926,26281,5699,7311,5595,10818,5577,5684,805,79109,8649,6711,8826,673,4684,118788,409,2905,2668,10142,2248,10718,5566,5706,2266,3815,5711,2549,2906,7314,5515,867,8822,5829,23035,80824,1445,4140,4763,1847,3567,399473,3630,5702,5516,4296,5922,3718,5747,64223,5906,2885,2674,2249,1850,2060,9462,3560,4747,5296,8394,27161,5714,816,2309,10213,111,6714,50852,5295,3932,8452,1026,5979,5698,54518,4193,112,58513,2675,5578,5159,7316,2903,10197,2676,9491,5923,2263,998,10817,2069,6457,2250,1849,9965,5526,3709,6654,8870,8396,5921,2261,6868,5701,10768,161742,2247,2335,84292,253260,7529,145957,8395,5682,5715,5525,808,26018,200734,7409,5685,3717,221002,108,5594,10000,5293,3708,5335,1848,930,3568,5170,5690,57690,5686,6712,8038,1742,107,26523,8315,1956,55824,1839,2904,3710,5796,6464,5924,2264,5291,10156,5704,10253,27327,156	ARTN,CSF2,MET,PRKAR2A,ARRB1,STAM,FGF22,AGO4,KL,FGA,PSMC1,PRKAR1B,KITLG,IL2RA,RPS6KB2,FGFR1,PIP4K2C,HGF,PDE1A,RASGRP3,FGF6,LAMTOR2,IL3,PRKACB,MAP2K2,RPS27A,PSMD1,ADCY4,PSMD12,PPP2R5D,FGF8,HRAS,EPN1,PTPN3,PEA15,KBTBD7,PIP5K1C,PSMB6,DUSP4,PRKCG,VWF,RAPGEF2,ADAM10,PHLPP1,PPP2R5E,PSMD13,PIK3CA,ARHGEF7,PTPN11,FGF9,GFRA4,MIR5004,HGS,ITGA2B,AKT2,CAMK2D,TRIB3,FYN,PSMB5,ICOS,CD80,MTOR,NR4A1,IL17RD,IRS2,CDKN1B,PDGFRA,GSK3B,ERBB3,LAT,PSMB3,FGF23,AKT1,SHC2,DUSP10,FGB,PSME1,IL2,RASAL1,VCL,CAMK2G,ERBB4,PDGFB,RASGRP1,PSMD4,PSMA8,TP53,ACTN2,PSME4,SEM1,AGO3,DUSP2,SH3GL2,INSR,CD86,PSMB4,FGF10,GSK3A,NRAS,PSMB11,SPTB,SH3GL1,ADCY8,ADCY9,ITGB3,SPTA1,KSR2,RANBP9,PDGFA,IRS1,BTC,PRKAR1A,TEK,AKT1S1,THEM4,ERBB2,PTPN12,PPP2R5C,CHUK,NRG1,PSMD11,PPP2R1B,PSMD2,RASGRP4,FGF1,PSMD6,PRKACG,SHC3,PRKCE,PDE1B,RAF1,STAM2,PRR5,PSMA6,FGF18,NRG2,CALM1,PHB1,EGF,SPTAN1,TSC2,PEBP1,ADCY7,PTPRA,JAK1,RAP1B,KRAS,CAMK2A,SPTBN5,PPP2R1A,PTEN,FGF7,ADCY3,PSMB7,PIK3R3,CAMK4,ANGPT1,TNRC6B,SYNGAP1,CREB1,DUSP1,PSMB8,SPTBN4,CSF2RB,CD28,PPP5C,PIP4K2A,PSPN,MAP2K1,PRKCD,SPRY1,FOXO1,DAB2IP,CASP9,MOV10,NRTN,RBX1,PAQR3,CNKSR1,PSMD7,PDE1C,RASAL3,FGF20,PSMB10,UBA52,MAPK3,FRS2,PRKAR2B,PSMA3,CALM2,MAPKAP1,LAMTOR3,SPTBN1,IQGAP1,BRAF,NCAM1,PIK3AP1,ARRB2,GRIN2C,GDNF,AKAP9,FGF3,NRG3,PRKACA,PSMC6,FGG,KIT,PSMD5,GAB1,GRIN2D,UBB,PPP2CA,CBL,FGF17,PXN,PHLPP2,DUSP16,CSK,MARK3,NF1,DUSP5,IL5,SPRED3,INS,PSMC3,PPP2CB,MAP3K11,RASA2,JAK3,PTK2,MLST8,RAP1A,GRB2,GFRA1,FGF4,DUSP8,EPS15,RASAL2,IL2RB,NEFL,PIK3R2,PIP5K1A,AGO2,PSMD8,CAMK2B,FOXO3,PSMD14,ADCY5,SRC,TRAT1,PIK3R1,LCK,CUL3,CDKN1A,RET,PSMB9,APBB1IP,MDM2,ADCY6,EPS15L1,GFRA2,PRKCA,PDGFRB,UBC,GRIN2A,PSME3,GFRA3,PSMF1,RASGRF1,FGFR2,CDC42,FRS3,EREG,SH3GL3,FGF5,DUSP7,FGF19,PPP2R5B,ITPR2,SOS1,IER3,PIP4K2B,RASA1,FGFR3,ADAM17,PSMC2,AHCYL1,SPRED1,FGF2,FN1,WDR83,RICTOR,YWHAB,NRG4,PIP5K1B,PSMA1,PSMD9,PPP2R5A,CALM3,LRIG1,SPRED2,VAV1,PSMA4,JAK2,RASGEF1A,ADCY2,MAPK1,AKT3,PIK3CD,ITPR1,PLCG1,DUSP6,CD19,IL5RA,PDPK1,PSMB2,TNRC6C,PSMA5,SPTBN2,ADAM12,DLG4,ADCY1,AGO1,BRAP,EGFR,PAG1,HBEGF,GRIN2B,ITPR3,PTPRK,SHC1,RASGRF2,FGFR4,PIK3CB,RASA4,PSMC4,SPRY2,TNRC6A,GRK2
R-HSA-187037	NGF signalling via TRKA from the plasma membrane	0.000903978124040031	-7.00870539693566	387	359	0.0397387646668143	9034	10285	408,4233,28956,2251,25780,9365,192670,3559,4208,5700,196883,2253,6233,5567,5707,8682,5694,3265,100847012,64096,23239,5582,9693,1846,5290,2534,57761,1398,208,8660,8074,27040,2065,161,1759,29851,3164,6016,54756,3558,818,2066,2244,5720,192669,10125,114,2255,942,7010,2889,10048,5154,283455,6708,3690,115727,5708,53358,5581,5568,5519,1147,3084,801,6709,8817,5687,55615,5894,5728,5518,7867,3716,284,1843,2252,814,5305,5604,940,57731,5713,152559,1175,5137,153090,842,4902,4343,805,5684,7311,26281,5600,5699,5577,5595,409,10142,2905,6711,5607,4684,8826,4914,5711,3815,2906,10718,2248,2266,1785,51231,8822,64223,5906,5747,5922,9462,1850,2249,3567,4763,27161,8394,3560,4747,5979,1026,8452,4193,54518,5698,1432,10213,10126,5578,5159,7316,112,2675,5898,2263,10817,2903,5923,2676,10197,2261,2247,161742,10768,9965,5921,8870,3709,5526,7529,84292,5525,5715,1173,3708,163,3568,5170,930,7409,221002,1742,6712,5690,5899,1839,1956,26523,107,8315,6195,5704,10156,27327,6464,6196,1437,9048,5576,3082,79837,5136,2243,27006,2260,6199,4254,5575,5528,5718,26052,5605,6774,3562,117,23396,84078,3674,2254,5781,7450,5719,5529,4803,817,5693,1211,1027,5691,1213,2932,5156,2475,941,5900,8437,5155,7414,11221,25759,207,23198,88,5598,7157,6456,1844,7979,143471,5710,4893,122706,9252,5603,6710,2931,5692,3643,6014,685,5573,84335,115,3667,9861,2246,2064,117145,5527,5717,5245,7249,5037,1950,5153,9542,815,51332,57498,5786,113,3845,5908,8831,1385,23112,5695,109,8503,160,5623,1439,5696,5536,10256,9978,64926,2308,5580,79109,116,10818,118788,2668,8649,673,2549,5566,5706,80824,23035,4140,1445,7314,387,5515,2674,2885,3718,4296,3630,399473,1847,5516,5702,5714,2309,816,5296,135,3932,50852,6714,111,5295,4205,2069,9491,5701,2335,2250,1849,8396,6654,200734,808,145957,253260,5682,8395,5335,10000,5594,5293,1848,466,108,3717,5685,6300,9261,57690,5686,4915,5291,2264,156,2904,5924,3710	ARRB1,MET,LAMTOR2,FGF6,RASGRP3,KL,AGO4,IL2RA,MEF2C,PSMC1,ADCY4,FGF8,RPS27A,PRKACB,PSMD1,PEA15,PSMB6,HRAS,MIR5004,GFRA4,PHLPP1,PRKCG,RAPGEF2,DUSP4,PIK3CA,FYN,TRIB3,CRK,AKT2,IRS2,FGF23,LAT,ERBB3,AP2A2,DNM1,ICOS,NR4A1,RIT1,IL17RD,IL2,CAMK2G,ERBB4,FGB,PSME1,AGO3,RASGRP1,ADCY8,FGF10,CD86,TEK,RAPGEF1,RANBP9,PDGFA,KSR2,SPTA1,ITGB3,RASGRP4,PSMD2,SHC3,PRKCE,PRKACG,PPP2R1B,CHUK,NRG1,CALM1,SPTAN1,FGF18,PSMA6,PRR5,RAF1,PTEN,PPP2R1A,MAPKAPK3,JAK1,ANGPT1,DUSP1,FGF7,CAMK4,PIP4K2A,MAP2K1,CD28,SPTBN4,PSMD7,PAQR3,AP2S1,PDE1C,DAB2IP,CASP9,NRTN,MOV10,CALM2,PSMA3,UBA52,FGF20,MAPK11,PSMB10,PRKAR2B,MAPK3,ARRB2,AKAP9,GRIN2C,SPTBN1,MAP2K5,NCAM1,IQGAP1,NTRK1,PSMD5,KIT,GRIN2D,NRG3,FGF3,FGG,DNM2,VRK3,FGF17,MLST8,RAP1A,PTK2,RASA2,RASAL2,DUSP8,FGF4,IL5,NF1,AGO2,PIP5K1A,IL2RB,NEFL,RET,CDKN1A,CUL3,MDM2,APBB1IP,PSMB9,MAPK14,PSMD14,DNAL4,PRKCA,PDGFRB,UBC,ADCY6,GFRA2,RALA,FGFR2,FRS3,GRIN2A,RASGRF1,GFRA3,PSME3,FGFR3,FGF2,SPRED1,AHCYL1,FGF19,RASA1,IER3,ITPR2,PPP2R5B,YWHAB,WDR83,PPP2R5A,PSMD9,AP2M1,ITPR1,AP2B1,IL5RA,PDPK1,CD19,VAV1,RASGEF1A,DLG4,SPTBN2,PSMB2,RALB,HBEGF,EGFR,AGO1,ADCY1,BRAP,RPS6KA1,PSMC4,RASA4,TNRC6A,SHC1,RPS6KA2,CSF2,ARTN,PRKAR2A,HGF,PIP4K2C,PDE1A,FGA,FGF22,FGFR1,RPS6KB2,KITLG,PRKAR1B,PPP2R5D,PSMD12,DNM3,MAP2K2,STAT3,IL3,ADCYAP1R1,PIP5K1C,KBTBD7,ITGA2B,FGF9,PTPN11,VWF,PSMD13,PPP2R5E,NGF,CAMK2D,PSMB5,CLTA,CDKN1B,PSMB3,CLTC,GSK3B,PDGFRA,MTOR,CD80,RALGDS,RASAL1,PDGFB,VCL,DUSP10,SHC2,AKT1,PSME4,ACTN2,MAPK7,TP53,SH3GL2,DUSP2,SEM1,PSMA8,PSMD4,NRAS,PSMB11,RPS6KA5,MAPK13,SPTB,GSK3A,PSMB4,INSR,RIT2,BTC,PRKAR1A,AKT1S1,ADCY9,IRS1,PSMD6,FGF1,ERBB2,THEM4,PPP2R5C,PSMD11,PHB1,TSC2,PEBP1,EGF,PDE1B,NRG2,CAMK2A,SPTBN5,KIDINS220,PTPRA,ADCY7,KRAS,RAP1B,SYNGAP1,CREB1,TNRC6B,PSMB7,ADCY3,PIK3R3,AP2A1,PSPN,CSF2RB,PSMB8,PPP5C,CNKSR1,RBX1,RASAL3,FOXO1,PRKCD,MAPKAP1,ADCYAP1,FRS2,PIK3AP1,GDNF,LAMTOR3,BRAF,GAB1,PRKACA,PSMC6,DUSP16,PHLPP2,MARK3,CSK,UBB,RHOA,PPP2CA,GFRA1,GRB2,JAK3,MAP3K11,INS,SPRED3,DUSP5,PPP2CB,PSMC3,PSMD8,FOXO3,CAMK2B,PIK3R2,ADORA2A,LCK,TRAT1,SRC,ADCY5,PIK3R1,MEF2A,EREG,PSMF1,PSMC2,FN1,FGF5,DUSP7,PIP4K2B,SOS1,SPRED2,CALM3,NRG4,RICTOR,PSMA1,PIP5K1B,PLCG1,AKT3,MAPK1,PIK3CD,DUSP6,ATF1,ADCY2,JAK2,PSMA4,MAPK12,MAPKAPK2,TNRC6C,PSMA5,NTRK2,PIK3CB,FGFR4,GRK2,GRIN2B,RASGRF2,ITPR3
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	0.00103131208769738	-6.8769234158757	87	85	0.00940889971219836	9034	10285	2250,5154,9965,3667,5526,8396,8870,5528,118788,685,2261,2247,2253,2248,10718,145957,2064,5527,3084,8395,5519,5525,3815,2549,2246,23396,4233,5159,26281,3643,942,9365,27006,2255,4254,5595,10818,2260,79837,2263,3082,2069,2251,29851,2252,941,8503,5296,8660,8394,1839,5156,1956,8074,2065,207,50852,6714,940,5295,3932,5291,5305,2264,2066,5155,7409,5529,8822,5515,5290,8817,9542,5594,5293,5781,930,1950,2254,3630,5516,2885,5518,2249,2534	FGF5,PDGFA,FGF19,IRS1,PPP2R5B,PIP4K2B,IER3,PPP2R5D,PIK3AP1,BTC,FGFR3,FGF2,FGF8,FGF3,NRG3,NRG4,ERBB2,PPP2R5C,NRG1,PIP5K1B,PPP2R1B,PPP2R5A,KIT,GAB1,FGF1,PIP5K1C,MET,PDGFRB,FGF20,INSR,CD86,KL,FGF22,FGF10,KITLG,MAPK3,FRS2,FGFR1,PIP4K2C,FGFR2,HGF,EREG,FGF6,ICOS,FGF7,CD80,PIK3R3,PIK3R2,IRS2,PIP5K1A,HBEGF,PDGFRA,EGFR,FGF23,ERBB3,AKT1,TRAT1,SRC,CD28,PIK3R1,LCK,PIK3CB,PIP4K2A,FGFR4,ERBB4,PDGFB,VAV1,PPP2R5E,FGF17,PPP2CA,PIK3CA,FGF18,NRG2,MAPK1,PIK3CD,PTPN11,CD19,EGF,FGF9,INS,PPP2CB,GRB2,PPP2R1A,FGF4,FYN
R-HSA-111885	Opioid Signalling	0.00128305954165701	-6.65850778627502	85	83	0.00918751383661722	9034	10285	5530,5516,2782,113,2774,729966,5533,1020,5518,5515,5331,108,5582,5173,5153,51764,5141,59345,801,3708,5594,10681,5499,3710,2792,2779,111,156,5143,2784,5330,814,346562,55970,107,109,54331,94235,1385,5532,5575,5321,2780,5577,114,5136,5144,2783,805,5443,5576,112,5580,5137,2771,2791,4988,406974,5578,5519,2786,2770,2790,84152,5142,5566,2773,2793,5568,808,5332,5534,2788,3709,2787,23236,115,5567,10768,5528,196883,2781,5573	PPP3CA,PPP2CB,GNB1,ADCY7,GNAL,CIST1,PPP3CC,CDK5,PPP2R1A,PPP2CA,PLCB3,ADCY2,PRKCG,PDYN,PDE1B,GNG13,PDE4A,GNB4,CALM1,ITPR1,MAPK1,GNB5,PPP1CA,ITPR3,GNGT1,GNAT1,ADCY5,GRK2,PDE4C,GNB3,PLCB2,CAMK4,GNAT3,GNG12,ADCY1,ADCY3,GNG2,GNG8,CREB1,PPP3CB,PRKAR1B,PLA2G4A,GNAT2,PRKAR2B,ADCY8,PDE1A,PDE4D,GNB2,CALM2,POMC,PRKAR2A,ADCY6,PRKCD,PDE1C,GNAI2,GNG11,OPRM1,MIR197,PRKCA,PPP2R1B,GNG4,GNAI1,GNG10,PPP1R1B,PDE4B,PRKACA,GNAI3,GNGT2,PRKACG,CALM3,PLCB4,PPP3R1,GNG7,ITPR2,GNG5,PLCB1,ADCY9,PRKACB,AHCYL1,PPP2R5D,ADCY4,GNAZ,PRKAR1A
R-HSA-8848021	Signaling by PTK6	0.00169072035922707	-6.3826005928017	67	66	0.00730573389417755	9034	10285	9564,9844,1019,1027,8831,5879,1956,1839,2065,207,2034,10156,8437,2066,3091,387,7314,867,9542,5829,1950,63916,100847012,4763,399473,1398,5770,3845,5753,5922,6725,2909,9462,595,55620,6774,116985,6233,5921,685,161742,1793,3265,6421,202559,2064,2908,145957,10718,3084,200734,1796,153090,10657,10457,898,27043,7316,64926,9021,7311,1017,120892,4893,2069,10656	BCAR1,ELMO1,CDK4,CDKN1B,SYNGAP1,RAC1,EGFR,HBEGF,ERBB3,AKT1,EPAS1,RASA4,RASAL1,ERBB4,HIF1A,RHOA,UBB,CBL,NRG2,PXN,EGF,ELMO2,MIR5004,NF1,SPRED3,CRK,PTPN1,KRAS,PTK6,RASA2,SRMS,ARHGAP35,RASAL2,CCND1,STAP2,STAT3,ARAP1,RPS27A,RASA1,BTC,SPRED1,DOCK1,HRAS,SFPQ,KHDRBS2,ERBB2,NR3C1,NRG4,NRG3,NRG1,SPRED2,DOK1,DAB2IP,KHDRBS1,GPNMB,CCNE1,PELP1,UBC,RASAL3,SOCS3,UBA52,CDK2,LRRK2,NRAS,EREG,KHDRBS3
R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	0.00171085838575452	-6.37076005444396	49	49	0.00542395395173788	9034	10285	5111,5934,1647,1869,1874,57472,246175,55571,995,4848,7157,1263,898,23019,3276,4850,2033,5325,1017,7029,2810,581,144455,4869,55835,4849,1027,7027,890,25904,7832,10498,8900,1026,891,1820,9125,29883,5933,57060,85456,28984,25946,6790,9134,9337,100302237,10769,983	PCNA,RBL2,GADD45A,E2F1,E2F4,CNOT6,CNOT6L,CNOT11,CDC25C,CNOT2,TP53,PLK3,CCNE1,CNOT1,PRMT1,CNOT4,EP300,PLAGL1,CDK2,TFDP2,SFN,BAX,E2F7,NPM1,CENPJ,CNOT3,CDKN1B,TFDP1,CCNA2,CNOT10,BTG2,CARM1,CCNA1,CDKN1A,CCNB1,ARID3A,CNOT9,CNOT7,RBL1,PCBP4,TNKS1BP1,RGCC,ZNF385A,AURKA,CCNE2,CNOT8,MIR1281,PLK2,CDK1
R-HSA-186763	Downstream signal transduction	0.00212363242656469	-6.1546272477515	352	326	0.0360858977197255	9034	10285	51332,815,5518,5728,3716,3845,5908,113,5786,1950,6709,5037,7249,801,5245,55615,5894,9542,8817,5687,5153,5623,5604,5305,5536,57731,5696,940,1439,6776,1843,284,8831,23112,1385,8503,814,109,2252,5695,114,6710,122706,4893,5692,3643,942,2931,2255,192669,6772,7979,1844,23198,88,7157,143471,5710,10125,2246,5581,53358,5568,9861,5708,115727,3084,5527,1147,5717,5519,117145,2064,84335,2889,5573,685,7010,3667,6708,3690,115,5154,10048,283455,5693,2534,57761,817,208,1398,5781,3674,100847012,64096,2254,5529,5719,5290,5582,1846,9693,7450,23239,818,2066,7414,5155,3558,8437,5720,25759,207,2244,11221,2932,5156,27040,8074,5691,2065,8660,1027,3164,54756,29851,2475,941,5136,25780,2251,28956,79837,3082,3559,4254,5575,5700,2260,6199,2243,192670,27006,9365,408,4233,5576,8440,9048,1437,84078,5694,23396,8682,3265,2253,5718,5528,196883,5707,5605,6233,6774,5567,3562,6712,1742,5686,5690,57690,930,1848,3568,5170,3708,5594,10000,5293,5335,3717,5685,108,221002,7409,6777,156,27327,10156,5291,2264,5704,3710,5924,6464,2904,1839,1956,4690,8315,107,26523,9564,2069,10817,2263,9491,10197,2676,5923,2903,7316,5159,5578,2675,112,200734,808,8395,5525,5715,5682,253260,84292,7529,145957,161742,2247,10768,2335,2261,5701,6654,3709,5526,5921,8870,8396,1849,2250,9965,2249,1850,9462,5922,3718,4296,64223,2674,5906,2885,5747,5702,5516,1847,4763,399473,3630,3567,1445,4140,23035,80824,5515,8822,7314,5698,54518,4193,3932,1026,5979,8452,5295,10213,6714,50852,111,2309,816,8394,5714,27161,4747,5296,6778,3560,79109,5684,805,10818,5595,5577,5699,26281,7311,5137,64926,152559,9978,5713,10256,4902,4343,5580,153090,842,2308,2549,2906,3815,5711,5706,2266,2248,10718,5566,10142,2668,2905,118788,409,8826,4684,673,6711,8649	SPTBN5,CAMK2A,PPP2R1A,PTEN,JAK1,KRAS,RAP1B,ADCY7,PTPRA,EGF,SPTAN1,PEBP1,TSC2,CALM1,PHB1,PRR5,RAF1,NRG2,FGF18,PSMA6,PDE1B,PSPN,MAP2K1,PIP4K2A,PPP5C,SPTBN4,PSMB8,CD28,CSF2RB,STAT5A,DUSP1,ANGPT1,SYNGAP1,TNRC6B,CREB1,PIK3R3,CAMK4,ADCY3,FGF7,PSMB7,ADCY8,SPTB,PSMB11,NRAS,PSMB4,INSR,CD86,GSK3A,FGF10,AGO3,STAT1,SEM1,DUSP2,PSME4,ACTN2,TP53,PSMA8,PSMD4,RASGRP1,FGF1,PRKCE,SHC3,PRKACG,PSMD6,PSMD2,RASGRP4,NRG1,PPP2R5C,CHUK,PSMD11,PPP2R1B,THEM4,ERBB2,AKT1S1,RAPGEF1,PRKAR1A,BTC,TEK,IRS1,SPTA1,ITGB3,ADCY9,PDGFA,RANBP9,KSR2,PSMB5,FYN,TRIB3,CAMK2D,AKT2,CRK,PTPN11,ITGA2B,MIR5004,GFRA4,FGF9,PPP2R5E,PSMD13,PIK3CA,PRKCG,DUSP4,RAPGEF2,VWF,PHLPP1,CAMK2G,ERBB4,VCL,PDGFB,IL2,RASAL1,PSME1,SHC2,AKT1,FGB,DUSP10,GSK3B,PDGFRA,LAT,FGF23,PSMB3,ERBB3,IRS2,CDKN1B,NR4A1,IL17RD,ICOS,MTOR,CD80,PDE1A,RASGRP3,FGF6,LAMTOR2,PIP4K2C,HGF,IL2RA,KITLG,PRKAR1B,PSMC1,FGFR1,RPS6KB2,FGA,AGO4,FGF22,KL,ARRB1,MET,PRKAR2A,NCK2,ARTN,CSF2,KBTBD7,PSMB6,PIP5K1C,PEA15,HRAS,FGF8,PSMD12,PPP2R5D,ADCY4,PSMD1,MAP2K2,RPS27A,STAT3,PRKACB,IL3,SPTBN2,DLG4,PSMA5,PSMB2,TNRC6C,CD19,DUSP6,IL5RA,PDPK1,ITPR1,MAPK1,AKT3,PIK3CD,PLCG1,JAK2,PSMA4,ADCY2,RASGEF1A,VAV1,STAT5B,GRK2,TNRC6A,RASA4,PIK3CB,FGFR4,PSMC4,ITPR3,RASGRF2,SHC1,GRIN2B,HBEGF,EGFR,NCK1,BRAP,ADCY1,AGO1,BCAR1,EREG,FRS3,FGFR2,PSMF1,PSME3,GFRA3,RASGRF1,GRIN2A,UBC,PDGFRB,PRKCA,GFRA2,ADCY6,SPRED2,CALM3,PIP5K1B,PPP2R5A,PSMD9,PSMA1,RICTOR,WDR83,YWHAB,NRG4,SPRED1,FGF2,AHCYL1,FN1,FGFR3,PSMC2,SOS1,ITPR2,PPP2R5B,RASA1,IER3,PIP4K2B,DUSP7,FGF5,FGF19,FGF4,DUSP8,RASAL2,RASA2,JAK3,MAP3K11,MLST8,GFRA1,RAP1A,GRB2,PTK2,PSMC3,PPP2CB,DUSP5,NF1,SPRED3,INS,IL5,CSK,MARK3,PHLPP2,DUSP16,PPP2CA,FGF17,UBB,PSMB9,APBB1IP,MDM2,LCK,CDKN1A,RET,CUL3,PIK3R1,PSMD14,SRC,TRAT1,ADCY5,FOXO3,CAMK2B,PIP5K1A,PSMD8,AGO2,NEFL,PIK3R2,STAT6,IL2RB,MAPKAP1,PSMA3,CALM2,FRS2,MAPK3,PRKAR2B,PSMB10,FGF20,UBA52,PDE1C,RASAL3,PAQR3,RBX1,PSMD7,CNKSR1,NRTN,MOV10,PRKCD,DAB2IP,CASP9,FOXO1,GAB1,GRIN2D,KIT,PSMD5,PSMC6,FGG,FGF3,NRG3,PRKACA,AKAP9,GDNF,GRIN2C,PIK3AP1,ARRB2,IQGAP1,NCAM1,BRAF,SPTBN1,LAMTOR3
R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	0.00217091703456371	-6.13260560412541	372	344	0.0380783705999557	9034	10285	805,5684,7311,5699,26281,5595,5713,152559,153090,842,4902,4343,5711,3815,2906,10718,2248,2266,409,10142,2905,6711,4684,8826,5906,64223,5747,5922,9462,1850,2249,3567,4763,8822,5979,1026,8452,4193,54518,5698,10213,27161,8394,3560,4747,2263,10817,2903,5923,10197,2676,7316,5159,2675,5970,7529,84292,5715,5525,9846,2261,2247,161742,10768,9965,5921,8870,5526,3709,1742,6712,5609,5690,5530,3708,5170,3568,930,7409,221002,5704,10156,27327,6464,23118,1839,1956,26523,8315,28956,25780,2251,192670,9365,3559,5700,3937,408,4233,8682,5534,5694,7335,3265,2253,6233,5707,2534,57761,208,8915,100847012,64096,23239,1846,9693,5290,5062,3558,818,2066,2244,5720,8660,8074,27040,2065,29851,54756,3164,4773,2255,942,192669,10125,115727,5708,53358,5519,7462,1147,3084,7010,4772,5154,10048,283455,6708,3690,5518,5728,4775,7189,10451,2207,3716,801,6709,8817,5687,55615,5894,5305,5604,940,57731,4790,284,1843,2252,7322,79109,84433,10818,10256,9978,64926,2308,2549,4067,5706,118788,2668,8649,6885,673,2885,2674,3718,4296,6416,3630,399473,1847,5516,5702,80824,23035,4140,1445,7314,5515,3932,50852,6714,10892,5295,5714,3551,2309,816,2353,5296,2069,7410,9491,8945,200734,808,997,145957,253260,5682,8395,9402,5701,4792,2335,5588,2250,1849,8396,23291,6654,10454,5336,57690,2205,5686,8454,5335,5594,5293,10000,1848,2206,4214,3717,5685,2264,5291,2904,5924,3710,7321,3082,79837,2243,27006,2260,6199,4254,1437,9048,23396,84078,3725,5718,5528,5605,3562,5058,3702,817,5693,7294,5602,3674,2254,5781,7450,5529,5719,8437,5155,7414,11221,25759,207,1027,5691,2932,5156,941,2475,122706,4893,6710,2931,5692,3643,5532,23198,88,7157,1844,7979,143471,5710,9861,10235,2246,2064,6850,117145,5717,5527,685,5601,84335,3667,51332,815,5786,3845,5908,5245,7249,5037,1950,9542,6500,5623,1439,5696,5536,5879,23112,1385,8831,5695,7334,5599,8503	CALM2,PSMA3,UBA52,PSMB10,FGF20,MAPK3,PSMD7,PAQR3,DAB2IP,CASP9,NRTN,MOV10,PSMD5,KIT,GRIN2D,NRG3,FGF3,FGG,ARRB2,AKAP9,GRIN2C,SPTBN1,NCAM1,IQGAP1,RAP1A,MLST8,PTK2,RASA2,RASAL2,DUSP8,FGF4,IL5,NF1,FGF17,RET,CDKN1A,CUL3,MDM2,APBB1IP,PSMB9,PSMD14,AGO2,PIP5K1A,IL2RB,NEFL,FGFR2,FRS3,GRIN2A,RASGRF1,PSME3,GFRA3,UBC,PDGFRB,GFRA2,RELA,YWHAB,WDR83,PSMD9,PPP2R5A,GAB2,FGFR3,FGF2,SPRED1,AHCYL1,FGF19,RASA1,IER3,PPP2R5B,ITPR2,DLG4,SPTBN2,MAP2K7,PSMB2,PPP3CA,ITPR1,PDPK1,IL5RA,CD19,VAV1,RASGEF1A,PSMC4,RASA4,TNRC6A,SHC1,TAB2,HBEGF,EGFR,AGO1,BRAP,LAMTOR2,RASGRP3,FGF6,AGO4,KL,IL2RA,PSMC1,LCP2,ARRB1,MET,PEA15,PPP3R1,PSMB6,UBE2V1,HRAS,FGF8,RPS27A,PSMD1,FYN,TRIB3,AKT2,BCL10,MIR5004,GFRA4,PHLPP1,DUSP4,RAPGEF2,PIK3CA,PAK2,IL2,CAMK2G,ERBB4,FGB,PSME1,IRS2,FGF23,LAT,ERBB3,ICOS,IL17RD,NR4A1,NFATC2,FGF10,CD86,AGO3,RASGRP1,RASGRP4,PSMD2,SHC3,PPP2R1B,LAT2,CHUK,NRG1,TEK,NFATC1,PDGFA,RANBP9,KSR2,SPTA1,ITGB3,PPP2R1A,PTEN,NFATC3,TRAF6,VAV3,FCER1G,JAK1,CALM1,SPTAN1,FGF18,PSMA6,PRR5,RAF1,PIP4K2A,MAP2K1,CD28,SPTBN4,NFKB1,ANGPT1,DUSP1,FGF7,UBE2D2,MAPKAP1,CARD11,FRS2,CNKSR1,RBX1,RASAL3,FOXO1,GAB1,LYN,PSMC6,PIK3AP1,GDNF,LAMTOR3,MAP3K7,BRAF,GRB2,GFRA1,JAK3,MAP3K11,MAP2K4,INS,SPRED3,DUSP5,PPP2CB,PSMC3,DUSP16,PHLPP2,MARK3,CSK,UBB,PPP2CA,LCK,TRAT1,SRC,MALT1,PIK3R1,PSMD8,IKBKB,FOXO3,CAMK2B,FOS,PIK3R2,EREG,VAV2,PSMF1,BTRC,SPRED2,CALM3,CDC34,NRG4,RICTOR,PSMA1,PIP5K1B,GRAP2,PSMC2,NFKBIA,FN1,PRKCQ,FGF5,DUSP7,PIP4K2B,FBXW11,SOS1,TAB1,PLCG2,TNRC6C,FCER1A,PSMA5,CUL1,PLCG1,MAPK1,PIK3CD,AKT3,DUSP6,MS4A2,MAP3K1,JAK2,PSMA4,FGFR4,PIK3CB,GRIN2B,RASGRF2,ITPR3,UBE2D1,HGF,PIP4K2C,FGA,FGF22,FGFR1,RPS6KB2,KITLG,CSF2,ARTN,PIP5K1C,KBTBD7,JUN,PSMD12,PPP2R5D,MAP2K2,IL3,PAK1,ITK,CAMK2D,PSMB5,TXK,MAPK10,ITGA2B,FGF9,PTPN11,VWF,PPP2R5E,PSMD13,RASAL1,PDGFB,VCL,DUSP10,SHC2,AKT1,CDKN1B,PSMB3,GSK3B,PDGFRA,CD80,MTOR,PSMB11,NRAS,SPTB,GSK3A,PSMB4,INSR,PPP3CB,PSME4,ACTN2,TP53,DUSP2,SEM1,PSMA8,PSMD4,PSMD6,RASGRP2,FGF1,ERBB2,SYK,THEM4,PSMD11,PPP2R5C,BTC,MAPK9,AKT1S1,IRS1,SPTBN5,CAMK2A,PTPRA,KRAS,RAP1B,PHB1,TSC2,PEBP1,EGF,NRG2,SKP1,PSPN,CSF2RB,PSMB8,PPP5C,RAC1,TNRC6B,CREB1,SYNGAP1,PSMB7,UBE2N,MAPK8,PIK3R3
R-HSA-373080	Class B/2 (Secretin family receptors)	0.00272600613458311	-5.904917695313	92	89	0.00985167146336064	9034	10285	1392,2790,2641,2786,8323,9340,6608,7482,50846,2787,8321,90226,2696,11211,7349,2535,7472,5744,2695,10267,2792,7475,7477,2692,7476,54331,7480,976,55970,6469,5741,2782,10681,8324,84658,1395,59345,10203,2788,51384,2793,3549,7474,6343,117,10266,30817,2783,2778,1394,133,116,8325,2691,7484,114131,1604,2015,10268,2791,2740,7479,8326,2784,7471,1393,7483,89780,8643,7855,113091,7976,94235,7478,796,8322,5745,7481,80326,797,799,3375,5746,2642,54361,7473,6344,51764,5727	CRH,GNG10,GCG,GNG4,FZD6,GLP2R,SMO,WNT2B,DHH,GNG5,FZD1,UCN2,GIPR,FZD10,UCN,FZD2,WNT2,PTHLH,GIP,RAMP1,GNGT1,WNT6,WNT7B,GHRHR,WNT7A,GNG2,WNT10B,ADGRE5,GNG12,SHH,PTH,GNB1,GNB5,FZD7,ADGRE3,CRHR2,GNB4,CALCRL,GNG7,WNT16,GNGT2,IHH,WNT5A,SCT,ADCYAP1R1,RAMP2,ADGRE2,GNB2,GNAS,CRHR1,ADM,ADCYAP1,FZD8,GHRH,WNT9B,UCN3,CD55,ADGRE1,RAMP3,GNG11,GLP1R,WNT8B,FZD9,GNB3,WNT1,CRHBP,WNT9A,WNT3A,PTCH2,FZD5,PTH2,FZD3,GNG8,WNT8A,CALCA,FZD4,PTH1R,WNT11,WNT10A,CALCB,CALCR,IAPP,PTH2R,GCGR,WNT4,WNT3,SCTR,GNG13,PTCH1
R-HSA-5653656	Vesicle-mediated transport	0.00280103009426737	-5.87776803864643	650	593	0.0656409121098074	9034	10285	6272,5048,1278,57148,81567,10244,10749,5321,3831,51164,83696,1777,9135,128866,408,92421,122830,23303,100313843,23095,57369,7018,10618,374,55614,127833,5866,11070,6396,949,100500842,51429,54453,8398,10960,3833,23046,80006,147700,6233,4012,60684,6517,9267,51422,26119,54536,27333,208,10671,137492,81631,11345,57533,57186,8685,10920,100616314,10484,60560,219770,26153,57511,2707,10945,55048,23166,154,9892,4253,5049,10804,2700,2799,288,551,64147,161,90019,63908,51138,1759,2804,7082,378,10096,3835,4481,9026,10342,54874,22989,3263,1778,259173,10260,3240,26000,221458,7163,1277,79090,23011,11337,23208,64689,8674,2665,2709,51693,9527,10808,51128,10109,9909,57644,8867,4624,5861,6708,6811,286133,55707,79748,10640,23149,6709,801,51542,5648,79720,57731,25839,22836,3832,55770,23062,950,382,84694,351,372,2844,7879,60561,1176,805,8976,1639,274,54734,948,7311,4122,160518,79958,1175,3798,29988,25978,375056,23423,636,91949,140735,7037,7109,8218,22879,23048,1785,547,11015,1281,409,3482,57465,6711,22872,1601,79890,1129,10094,10525,9882,89866,26258,2890,4620,23647,84079,867,185,213,5265,56992,64837,4905,662,51534,8677,5872,3799,81035,10540,7532,55582,2495,6844,84313,10052,9610,10053,6457,83548,7531,23682,1315,26130,3797,10905,2800,7316,1362,1783,5898,25782,2697,58513,22796,4644,1781,90411,57706,8774,1173,7529,7533,127534,9332,5873,134829,11258,55275,55738,163259,6712,11311,9685,27348,8533,11127,157807,8408,1282,6288,22818,163,100500837,1453,23433,10959,79058,7039,11196,8907,27131,738,55850,2873,84958,5564,10427,23431,4035,26958,1956,4121,400,11014,51143,112574,5537,966,6836,335,4036,51014,8871,51552,8027,381,11021,23216,4622,9321,1780,8578,10466,79643,2803,23396,375,83874,60592,51028,51272,81876,29127,29924,84062,1522,2801,89781,9585,26052,201627,5870,23557,10552,51594,6453,117177,22930,1211,1294,259,64708,115548,287,11004,9554,254263,79571,9146,3043,8766,3512,3834,2590,5286,22878,4625,1856,2348,348,9183,9276,149111,78989,207,8675,10228,4626,1213,10093,29763,6678,10971,83452,162,84315,10282,6710,6455,23256,250,5571,124602,10092,55763,22920,89953,6456,6814,29993,23163,5878,3257,51762,3796,4218,84251,6857,920,85021,377,9847,126432,23243,3949,26984,3250,22898,9117,26088,79735,117156,57134,2153,7248,10972,1212,64746,11031,55083,9648,53632,51332,3320,27183,1122,8906,27128,8673,57679,54732,55667,7249,1950,57165,285643,1075,157,79961,27342,84364,10254,113220,11252,1523,10981,160,84643,9322,55014,4621,27147,5864,55291,10890,29979,8655,5879,146909,7164,2810,55357,149371,91782,6764,9341,11316,23299,1604,811,2017,22931,163486,10097,51510,50813,8615,130340,51256,81930,3092,8729,9570,152503,8546,3267,2702,5867,143425,7474,23637,125058,9950,11336,5565,9265,2060,273,2885,9829,414918,8542,1861,2512,3630,27314,58485,2706,51226,3039,9266,22905,54662,915,51112,53407,11267,338,7314,60412,4619,9632,10112,1284,55605,10226,128637,9382,6714,4646,3312,7110,3998,2580,8322,286,388552,9698,6810,22848,5563,51560,56894,85439,8735,84316,9856,10652,25977,7251,1062,9871,23258,11037,23265,10113,164,125111,808,4124,10717,22820,10802,5868,201475,10133,8567,55330,9525,10987,2589,9493,51652,1080,5869,4074,9712,26286,27095,8773,1174,9609,2701,84342,7534,10000,917,6869,5874,122553,2703,156,57589,6643,8301,55576,11154,50618,221960,10175,4641,339122,9318,81846,84516,64786,90196	SORT1,PAFAH1B1,COL1A2,RALGAPB,TXNDC5,RABEPK,KIF1C,PLA2G4A,KLC1,DCTN4,TRAPPC9,DNASE2,RABEP1,CHMP4B,ARRB1,CHMP4C,NAA30,KIF13B,MIR711,KIF1B,GJD2,TF,TGOLN2,AREG,KIF16B,SYT2,RAB3IL1,TMEM115,SEC13,SCARB1,MIR3652,SNX9,RIN2,PLA2G6,LMAN2,KIFC1,KIF21B,TRAPPC13,KLC3,RPS27A,LNPEP,TRAPPC11,SLC2A4,CYTH1,PRKAG2,LDLRAP1,EXOC6,GOLIM4,AKT2,DCTN6,VPS37A,MAP1LC3B,GABARAPL2,TBC1D14,RALGAPA2,MARCO,COPS8,MIR4750,SEC23A,NAA35,GJD4,KIF26A,COG6,GJB3,KDELR1,VPS37C,STAB1,ADRB2,SNAP91,MIA2,PAFAH1B2,GJB6,GJA3,GNS,ANK3,AVP,KIF9,AP2A2,SYT8,NAPB,COPS4,DNM1,GOLGB1,TJP1,ARF4,ACTR3,KIF22,MSR1,HIP1R,TFG,FNBP1L,MYH15,HPX,DYNC1H1,ALS2CL,DENND4A,HP,TBC1D10B,KIF6,TPD52,COL1A1,TRAPPC6A,RAB21,GABARAP,SYT11,GORASP1,VAMP4,GDI2,GJB5,TRAPPC2L,GOSR1,HSPH1,SAR1B,ARPC2,DENND4B,MYH7B,SYNJ1,MYH6,RAB1A,SPTA1,STX5,SCARA5,NECAP2,LMAN1L,EXOC5,FCHO1,SPTAN1,CALM1,VPS54,MASP1,VPS37B,SPTBN4,COG4,RHOBTB3,KIF11,EXOC2,GGA2,SCARB2,ARF6,GJA10,APP,ARCN1,GPR21,RAB7A,RINT1,AP3S1,CALM2,WASL,DCTN1,BIN1,RAB39A,CD36,UBA52,MAN2A2,DENND5B,DENND1C,AP2S1,KIF5A,SLC2A8,CHMP2B,MIA3,TMED3,BICD1,COG7,DYNLL2,TFRC,TRAPPC10,CLTCL1,MON1B,FNBP1,DNM2,KIF1A,KDELR3,COL3A1,ARRB2,IGF2R,TBC1D24,SPTBN1,SEC31A,DAB2,RIN3,CHRM2,ARPC3,HYOU1,TBC1D4,SEC16B,BLOC1S6,GRIA1,MYH2,ARFIP2,ANKRD27,CBL,AGTR1,ALB,SERPINA1,KIF15,KLC2,NSF,BNIP1,VTA1,STX10,RAB13,KIF5B,COLEC12,DCTN2,YWHAG,KIF27,FTH1,VAMP2,VPS25,GJC1,RIN1,AP1M2,SH3GL3,COG3,YWHAE,RAB38,COPB1,GAPVD1,KIF3C,MAN1A2,GOLGA1,UBC,CPD,DYNC1LI2,RALA,RAB3GAP2,GJA1,EPS15L1,COG2,MYO5A,DYNC1I2,MCFD2,DENND1A,NAPG,AP2M1,YWHAB,YWHAH,GJB4,CD163,RAB27A,CLVS2,DCTN3,VPS53,ARFGAP1,DENND2C,SPTBN2,VPS45,CLINT1,TOR1B,COPS3,KIF3A,CLVS1,ULK1,COL4A1,SAA1,COPZ1,AP2B1,MIR3606,CSNK1D,RHOQ,TMED2,ASPSCR1,TGFA,SEC23IP,AP1M1,SNX5,VPS51,USE1,GPS1,SYTL1,PRKAB1,SEC24B,AP4E1,LRP1,COPG2,EGFR,MAN1A1,ARL1,KDELR2,DYNC1LI1,SNX18,PPP6C,CD59,SURF4,APOA1,LRP2,TMED7,SYNJ2,RAB14,STAM,ARF5,RAB35,TBC1D1,MYH4,TRIP11,DYNC1I1,SCARF1,COG5,CHMP6,GOLGA4,PIP5K1C,ARF1,TBC1D10A,SCOC,VPS36,BET1L,RAB1B,RACGAP1,EPN1,DTNBP1,CTSZ,GOLGA2,HPS4,KIF20B,DNM3,DENND6A,RAB6A,SNAPIN,ARPC1A,NBAS,ITSN1,RAB3IP,RAB3GAP1,CLTA,COL7A1,AMBP,COPS7B,FCHO2,ANK2,KIF2C,SEC22B,CNIH2,GCC1,HGS,HBB,RAB11A,JCHAIN,KIF25,GALNT2,PIK3C2A,TRAPPC8,MYH7,DVL2,FOLR1,APOE,ZW10,COPB2,CNIH3,COLEC11,AKT1,STX16,STX6,MYH8,CLTC,ARPC4,PACSIN3,SPARC,YWHAQ,RAB33B,AP1B1,MON1A,BET1,SPTB,SH3GL1,SCFD1,ALPP,PRKAG1,KIF19,ARPC5,EXOC1,KIFAP3,KLC4,SH3GL2,STXBP3,PACSIN1,GGA3,RAB5C,HPS1,RAB8B,KIF2A,RAB8A,SGIP1,SYT1,CD4,REPS1,ARF3,C2CD5,RINL,ANKRD28,LDLR,SEC22A,HPR,DENND3,SEC22C,GGA1,TBC1D17,SCGB3A2,MAN1C1,F5,TSC1,TMED10,CLTB,ACBD3,RAB31,KIF26B,GCC2,PRKAG3,SPTBN5,HSP90AA1,VPS4A,CHML,AP1G2,CYTH4,VAMP8,ALS2,TMED9,DENND4C,TSC2,EGF,GJC2,KIF4B,CTSC,GRK3,DENND2D,RABGEF1,ARFGAP2,STAM2,KIF12,PACSIN2,CUX1,RAB32,AP2A1,KIF2B,TRIP10,STX17,MYH3,DENND2A,RAB3A,PPP6R3,RAB10,UBQLN1,DYNLL1,RAC1,KIF18B,TPD52L1,SFN,TBC1D2,EXOC8,CHMP7,DENND2B,VAMP3,COPE,BICD2,CD55,CALR,CTTN,RAB18,DENND1B,ACTR2,CHMP5,COPS7A,USO1,AP1S3,TBC1D7,KIF18A,HIP1,GBF1,GOSR2,SH3D19,AP3B1,AGFG1,GJA5,RAB4A,SYT9,WNT5A,RABGAP1,TBC1D16,GOLGA5,EXOC3,PRKAB2,CYTH3,EPS15,AMPH,GRB2,DNAJC6,DENND6B,APOL1,TOR1A,FTL,INS,RAB30,TRAPPC1,GJB2,COPZ2,HBA1,CYTH2,EPN2,TBC1D13,CD3D,TRAPPC12,STX18,SNF8,APOB,UBB,EXOC4,MYH1,SEC24C,KIF20A,COL4A2,KIF21A,PLIN3,TBC1D20,COG1,SRC,MYO6,HSPA8,TMF1,LMAN1,GAK,FZD4,ANK1,BLOC1S3,PUM1,STX4,AAK1,PRKAA2,RAB6B,AGPAT3,STON2,MYH13,NAA38,KIAA0319,YKT6,NECAP1,TSG101,CENPE,SEC24D,DENND5A,STON1,EXOC7,PREB,AP1G1,GJD3,CALM3,MAN2A1,AP4B1,COPG1,SEC24A,RAB5A,RAB12,OPTN,MADD,BLOC1S4,VPS4B,COPS5,GALNT1,KIF23,CHMP3,CFTR,RAB5B,M6PR,USP6NL,ARFGAP3,TRAPPC3,SNAP23,AP1S1,RAB36,GJA4,COG8,YWHAZ,AKT3,CD3G,TACR1,RAB27B,TRAPPC6B,GJA8,GRK2,RIC1,SNX2,PICALM,STAB2,AP4S1,ITSN2,CCZ1B,CNIH1,MYO1C,RAB43,COPS2,SBF2,DCTN5,TBC1D15,SYS1
R-HSA-2424491	DAP12 signaling	0.00302638186310878	-5.80038747755636	356	329	0.0364179765330972	9034	10285	5700,5575,3559,4254,6199,2260,192670,27006,9365,2243,5136,25780,2251,28956,79837,3082,4233,5576,9048,1437,408,3937,22914,3265,84078,23396,5694,8682,5707,3562,5567,6233,5605,2253,196883,5718,5528,208,57761,5693,2534,817,5719,5529,5290,1846,9693,7450,5582,23239,5781,2254,64096,3674,100847012,5720,207,25759,11221,2244,7414,818,2066,5155,3558,8437,54756,3164,29851,2475,941,5156,2932,2065,5691,27040,8074,8660,1027,942,3643,5692,2255,2931,6710,114,4893,122706,5710,143471,10125,7979,192669,1844,88,7157,23198,3084,5717,5527,1147,5519,117145,6850,2064,2246,9861,5568,5581,53358,5708,115727,3667,3690,115,6708,283455,5154,10048,84335,5573,685,7010,3716,5908,3845,113,5786,10451,51332,815,5518,5728,5894,55615,5687,8817,9542,5153,1950,6709,7249,5037,801,567,5245,5536,5696,57731,1439,940,5623,5604,5305,8503,814,2252,109,5695,1843,284,1385,8831,23112,5879,10818,5595,5577,3824,26281,5699,7311,79109,5684,805,4343,4902,5580,2308,842,153090,5137,64926,7305,9978,152559,10256,5713,5706,2266,2248,10718,5566,2549,2906,3815,5711,8826,673,4684,8649,6711,2905,2668,10142,118788,409,5702,5516,4763,1847,3567,399473,3630,1850,2249,9462,4296,3718,5922,100528032,5747,2885,64223,5906,2674,8822,5515,7314,1445,4140,23035,80824,5295,10213,111,6714,50852,54518,5698,4193,3932,8452,1026,5979,4747,5296,3560,816,2309,8394,27161,5714,2676,10197,9491,5923,2903,7410,10817,2069,2263,2675,112,7316,5159,5578,8395,5682,5525,5715,84292,253260,7529,145957,808,200734,5526,3709,6654,8396,8870,5921,2250,1849,9965,10768,2247,161742,2335,2261,5701,9402,5686,5690,57690,6712,1742,5336,5685,3717,108,221002,3133,7409,1848,930,3568,5170,10000,5594,5293,3708,5335,3710,5924,6464,2904,27327,156,2264,5291,10156,5704,8315,107,26523,1956,1839	PSMC1,PRKAR1B,IL2RA,KITLG,RPS6KB2,FGFR1,AGO4,FGF22,KL,FGA,PDE1A,RASGRP3,FGF6,LAMTOR2,PIP4K2C,HGF,MET,PRKAR2A,ARTN,CSF2,ARRB1,LCP2,KLRK1,HRAS,KBTBD7,PIP5K1C,PSMB6,PEA15,PSMD1,IL3,PRKACB,RPS27A,MAP2K2,FGF8,ADCY4,PSMD12,PPP2R5D,AKT2,TRIB3,PSMB5,FYN,CAMK2D,PSMD13,PPP2R5E,PIK3CA,DUSP4,RAPGEF2,VWF,PRKCG,PHLPP1,PTPN11,FGF9,GFRA4,ITGA2B,MIR5004,PSME1,AKT1,SHC2,DUSP10,FGB,VCL,CAMK2G,ERBB4,PDGFB,IL2,RASAL1,IL17RD,NR4A1,ICOS,MTOR,CD80,PDGFRA,GSK3B,ERBB3,PSMB3,LAT,FGF23,IRS2,CDKN1B,CD86,INSR,PSMB4,FGF10,GSK3A,SPTB,ADCY8,NRAS,PSMB11,PSMD4,PSMA8,RASGRP1,SEM1,AGO3,DUSP2,ACTN2,TP53,PSME4,NRG1,PSMD11,PPP2R5C,CHUK,PPP2R1B,THEM4,SYK,ERBB2,FGF1,PSMD6,PRKACG,PRKCE,SHC3,PSMD2,RASGRP4,IRS1,ITGB3,ADCY9,SPTA1,KSR2,PDGFA,RANBP9,AKT1S1,PRKAR1A,BTC,TEK,JAK1,RAP1B,KRAS,ADCY7,PTPRA,VAV3,SPTBN5,CAMK2A,PPP2R1A,PTEN,RAF1,PRR5,PSMA6,FGF18,NRG2,PDE1B,EGF,SPTAN1,TSC2,PEBP1,CALM1,B2M,PHB1,PPP5C,PSMB8,SPTBN4,CSF2RB,CD28,PSPN,MAP2K1,PIP4K2A,PIK3R3,CAMK4,FGF7,ADCY3,PSMB7,DUSP1,ANGPT1,CREB1,SYNGAP1,TNRC6B,RAC1,FRS2,MAPK3,PRKAR2B,KLRD1,FGF20,PSMB10,UBA52,MAPKAP1,PSMA3,CALM2,MOV10,NRTN,PRKCD,FOXO1,CASP9,DAB2IP,PDE1C,RASAL3,TYROBP,RBX1,PAQR3,CNKSR1,PSMD7,PSMC6,FGG,FGF3,NRG3,PRKACA,GAB1,GRIN2D,KIT,PSMD5,IQGAP1,BRAF,NCAM1,LAMTOR3,SPTBN1,GRIN2C,GDNF,AKAP9,PIK3AP1,ARRB2,PSMC3,PPP2CB,NF1,DUSP5,IL5,SPRED3,INS,DUSP8,FGF4,RASAL2,MAP3K11,JAK3,RASA2,KLRC4-KLRK1,PTK2,GRB2,MLST8,RAP1A,GFRA1,FGF17,PPP2CA,UBB,CSK,MARK3,PHLPP2,DUSP16,PIK3R1,PSMD14,ADCY5,SRC,TRAT1,APBB1IP,PSMB9,MDM2,LCK,CUL3,CDKN1A,RET,NEFL,PIK3R2,IL2RB,CAMK2B,FOXO3,PIP5K1A,AGO2,PSMD8,GFRA3,PSME3,PSMF1,RASGRF1,GRIN2A,VAV2,FRS3,EREG,FGFR2,GFRA2,ADCY6,UBC,PDGFRB,PRKCA,PIP5K1B,PSMA1,PPP2R5A,PSMD9,WDR83,RICTOR,YWHAB,NRG4,CALM3,SPRED2,PPP2R5B,ITPR2,SOS1,PIP4K2B,IER3,RASA1,FGF5,DUSP7,FGF19,AHCYL1,FGF2,SPRED1,FN1,FGFR3,PSMC2,GRAP2,PSMA5,PSMB2,TNRC6C,SPTBN2,DLG4,PLCG2,PSMA4,JAK2,ADCY2,RASGEF1A,HLA-E,VAV1,DUSP6,CD19,IL5RA,PDPK1,AKT3,MAPK1,PIK3CD,ITPR1,PLCG1,ITPR3,RASGRF2,SHC1,GRIN2B,TNRC6A,GRK2,FGFR4,PIK3CB,RASA4,PSMC4,BRAP,ADCY1,AGO1,EGFR,HBEGF
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	0.00302725128735138	-5.80010023707549	62	61	0.00675226920522471	9034	10285	6517,54536,51422,53632,208,8773,11127,10640,9882,8766,7534,4620,801,57186,79058,23433,5564,4619,60412,4625,207,4621,4626,10890,4641,5879,5872,55770,10971,6844,6810,7532,5563,7531,57148,2810,8735,5571,805,51552,149371,23216,55763,22920,4622,6814,22989,4218,23265,5898,4644,808,9847,7529,7533,5867,11336,5565,4012,4624,57644	SLC2A4,EXOC6,PRKAG2,PRKAG3,AKT2,SNAP23,KIF3A,EXOC5,TBC1D4,RAB11A,YWHAZ,MYH2,CALM1,RALGAPA2,ASPSCR1,RHOQ,PRKAB1,MYH1,EXOC4,MYH7,AKT1,MYH3,MYH8,RAB10,MYO1C,RAC1,RAB13,EXOC2,YWHAQ,VAMP2,STX4,YWHAG,PRKAA2,YWHAE,RALGAPB,SFN,MYH13,PRKAG1,CALM2,RAB14,EXOC8,TBC1D1,EXOC1,KIFAP3,MYH4,STXBP3,MYH15,RAB8A,EXOC7,RALA,MYO5A,CALM3,C2CD5,YWHAB,YWHAH,RAB4A,EXOC3,PRKAB2,LNPEP,MYH6,MYH7B
R-HSA-186797	Signaling by PDGF	0.00305350351607771	-5.79146565381077	376	347	0.0384104494133274	9034	10285	56034,10718,2248,2266,5711,3815,2906,6711,4684,8826,409,2905,10142,7311,26281,5699,5577,5595,805,5684,842,153090,4343,4902,5713,152559,5137,10213,8452,5979,1026,4193,54518,5698,3560,4747,27161,8394,3567,4763,5747,64223,5906,5922,9462,2249,1850,8822,7057,7529,84292,5715,5525,1286,7059,9965,8870,1285,5921,5526,3709,2261,10768,161742,2247,2903,5923,10197,2676,2263,10817,112,2675,5578,7316,5159,6464,5704,10156,27327,26523,107,8315,4690,1956,1839,5690,1282,7058,1742,6712,7409,256076,221002,3708,5170,3568,930,3265,8682,5694,1293,5567,6233,5707,196883,2253,192670,9365,5700,3559,25780,2251,28956,8440,4233,408,2244,5720,3558,818,2066,29851,3164,54756,8660,2065,8074,27040,1398,208,57761,2534,23239,5582,1846,9693,5290,64096,100847012,5519,1147,3084,115727,5708,5568,5581,53358,283455,10048,5154,3690,6708,7010,2889,2255,942,114,10125,192669,6772,940,57731,5305,5604,2252,814,284,1843,6776,3716,5518,5728,5687,8817,5894,55615,801,7060,6709,5566,5706,2549,80310,8649,673,118788,2668,10818,1298,79109,2308,5580,10256,9978,64926,111,1299,6714,50852,131873,5295,1284,3932,6778,5296,5714,816,2309,3630,399473,1847,5516,5702,2674,2885,4296,3718,7314,5515,80824,23035,4140,1445,145957,253260,5682,8395,808,200734,2250,1849,8396,6654,5701,2335,9491,5327,2069,1297,5045,2904,5924,3710,2264,5291,156,6777,9564,57690,5686,108,5685,3717,5335,5594,5293,10000,1848,23396,84078,3562,6774,5605,5528,5718,27006,2243,6199,2260,5575,4254,3082,79837,5136,1437,9048,5576,11221,207,25759,8437,5155,7414,2475,941,1027,5691,5156,2932,817,5693,7450,5529,5719,2254,3674,5781,5782,2064,117145,5340,5527,5717,9861,2246,115,3667,685,5573,84335,2931,3643,5692,4893,122706,6710,5710,143471,7157,88,23198,1844,7979,1439,5696,5536,5623,5695,109,8503,8831,23112,1385,6696,5786,113,5908,3845,51332,815,5153,9542,5245,5037,7249,1950	PDGFC,NRG3,FGF3,FGG,PSMD5,KIT,GRIN2D,SPTBN1,NCAM1,IQGAP1,ARRB2,GRIN2C,AKAP9,UBA52,FGF20,PSMB10,PRKAR2B,MAPK3,CALM2,PSMA3,CASP9,DAB2IP,MOV10,NRTN,PSMD7,PAQR3,PDE1C,PSMD14,CUL3,RET,CDKN1A,MDM2,APBB1IP,PSMB9,IL2RB,NEFL,AGO2,PIP5K1A,IL5,NF1,PTK2,MLST8,RAP1A,RASA2,RASAL2,FGF4,DUSP8,FGF17,THBS1,YWHAB,WDR83,PSMD9,PPP2R5A,COL4A4,THBS3,FGF19,IER3,COL4A3,RASA1,PPP2R5B,ITPR2,FGFR3,AHCYL1,SPRED1,FGF2,GRIN2A,RASGRF1,PSME3,GFRA3,FGFR2,FRS3,ADCY6,GFRA2,PRKCA,UBC,PDGFRB,SHC1,PSMC4,RASA4,TNRC6A,AGO1,ADCY1,BRAP,NCK1,EGFR,HBEGF,PSMB2,COL4A1,THBS2,DLG4,SPTBN2,VAV1,COL6A5,RASGEF1A,ITPR1,PDPK1,IL5RA,CD19,HRAS,PEA15,PSMB6,COL6A3,PRKACB,RPS27A,PSMD1,ADCY4,FGF8,AGO4,KL,PSMC1,IL2RA,RASGRP3,FGF6,LAMTOR2,NCK2,MET,ARRB1,FGB,PSME1,IL2,CAMK2G,ERBB4,ICOS,NR4A1,IL17RD,IRS2,ERBB3,FGF23,LAT,CRK,AKT2,TRIB3,FYN,PHLPP1,PRKCG,DUSP4,RAPGEF2,PIK3CA,GFRA4,MIR5004,PPP2R1B,CHUK,NRG1,RASGRP4,PSMD2,PRKACG,PRKCE,SHC3,KSR2,RANBP9,PDGFA,ITGB3,SPTA1,TEK,RAPGEF1,FGF10,CD86,ADCY8,RASGRP1,AGO3,STAT1,CD28,SPTBN4,PIP4K2A,MAP2K1,FGF7,CAMK4,ANGPT1,DUSP1,STAT5A,JAK1,PPP2R1A,PTEN,PSMA6,FGF18,RAF1,PRR5,CALM1,THBS4,SPTAN1,PRKACA,PSMC6,GAB1,PDGFD,LAMTOR3,BRAF,PIK3AP1,GDNF,FRS2,COL9A2,MAPKAP1,FOXO1,PRKCD,CNKSR1,RBX1,RASAL3,ADCY5,COL9A3,SRC,TRAT1,COL6A6,PIK3R1,COL4A2,LCK,STAT6,PIK3R2,PSMD8,CAMK2B,FOXO3,INS,SPRED3,DUSP5,PPP2CB,PSMC3,GFRA1,GRB2,MAP3K11,JAK3,UBB,PPP2CA,DUSP16,PHLPP2,MARK3,CSK,NRG4,RICTOR,PSMA1,PIP5K1B,CALM3,SPRED2,FGF5,DUSP7,PIP4K2B,SOS1,PSMC2,FN1,PSMF1,PLAT,EREG,COL9A1,FURIN,GRIN2B,RASGRF2,ITPR3,FGFR4,PIK3CB,GRK2,STAT5B,BCAR1,TNRC6C,PSMA5,ADCY2,PSMA4,JAK2,PLCG1,MAPK1,PIK3CD,AKT3,DUSP6,PIP5K1C,KBTBD7,IL3,STAT3,MAP2K2,PPP2R5D,PSMD12,FGF22,FGA,RPS6KB2,FGFR1,PRKAR1B,KITLG,HGF,PIP4K2C,PDE1A,CSF2,ARTN,PRKAR2A,DUSP10,AKT1,SHC2,RASAL1,PDGFB,VCL,MTOR,CD80,CDKN1B,PSMB3,PDGFRA,GSK3B,CAMK2D,PSMB5,VWF,PPP2R5E,PSMD13,FGF9,ITGA2B,PTPN11,PTPN12,ERBB2,THEM4,PLG,PPP2R5C,PSMD11,PSMD6,FGF1,ADCY9,IRS1,BTC,PRKAR1A,AKT1S1,GSK3A,INSR,PSMB4,NRAS,PSMB11,SPTB,PSMD4,PSMA8,TP53,ACTN2,PSME4,DUSP2,SEM1,CSF2RB,PSMB8,PPP5C,PSPN,PSMB7,ADCY3,PIK3R3,SYNGAP1,TNRC6B,CREB1,SPP1,PTPRA,ADCY7,RAP1B,KRAS,SPTBN5,CAMK2A,PDE1B,NRG2,PHB1,PEBP1,TSC2,EGF
R-HSA-500792	GPCR ligand binding	0.00344765052720386	-5.67006228653678	453	416	0.0460482621208767	9034	10285	11255,2921,2550,643,187,29933,8324,3357,553,51554,4852,6288,4158,54886,7476,5697,57007,5196,57105,10911,7475,3061,3350,624,6374,2832,7472,7349,6368,5995,1132,2852,6346,5368,259295,5724,56477,2787,6608,4923,1234,5020,23566,1241,4159,151306,84539,887,1907,5032,51764,4157,2853,5031,1269,1133,185,259296,1909,7473,51052,59340,799,134,1129,221391,338557,2914,1814,4922,152,5029,57121,53829,7976,8484,1131,4829,7471,5028,2831,150,7484,3062,5179,5367,2740,9034,10022,10886,1394,2492,5539,140,351,3640,10850,6343,1908,719,6360,1268,2150,2829,183,1128,51738,2788,134864,2922,885,6753,2847,2861,4160,54429,10681,6364,3827,7201,50835,50838,117579,10316,6469,2357,976,7480,4889,6751,9283,2863,148,4986,2797,222545,10267,5744,886,6863,4985,3579,5731,1524,611,83551,338398,6357,9340,5733,256933,727,387129,8111,2790,5729,2917,10874,2358,1230,5727,2865,2919,129521,3360,9038,80326,64805,50865,1081,10692,5732,3577,551,94235,8643,1237,154,2784,60675,27202,6755,4887,718,5443,2015,50834,6752,6370,3354,2798,2918,6866,347148,4543,259287,2359,3627,9718,6865,2862,3269,3363,6915,6869,84658,59345,1233,2912,50832,1812,1395,9288,6352,79948,2149,2488,3274,55970,5739,5660,3814,23620,84109,146,3361,2792,1880,80834,170589,6019,3972,59350,4987,94233,2796,846,8321,151,5540,6373,50846,50839,57486,7482,8323,1816,84634,2916,6846,259294,9294,64748,2641,623,1392,2915,7253,1815,6344,80835,259292,729230,3973,6010,2867,2642,10803,4295,8811,6750,9287,2841,53637,6372,2834,5726,2587,338442,7481,796,1236,8322,135,7483,89780,1325,1235,7252,7200,1393,3576,4161,163404,10663,1232,2913,1813,8326,1604,114131,3362,4988,50831,2791,4886,58191,5737,8325,116,133,30817,10266,1910,2778,10161,6375,2147,7474,6376,2911,50833,9890,1889,2793,51289,3355,5734,10203,1902,10563,2826,319100,136,2782,83756,5741,147,3356,54331,3792,259285,339403,257313,7477,8698,2532,2692,128674,122042,2535,2695,8477,10887,728,2837,11211,90226,165140,2151,2696,2864,594857,552,9568,6754,6363,1906,2786,3352,9934,5173,3351,5746,3375,4544,3060,155,23596,54361,259289,797,5745,9290,50837,7478,7855,113091,2920,7479,1903,11251,6366,56923,6387,122876,2691,10268,2859,5021,2783,64106,7852,117,259290,27199,56670,3549,6870,1901,51083,301,2693,153,51384,259286	HRH3,CXCL3,GABBR1,CXCR5,APLNR,GPR132,FZD7,HTR2B,AVPR1B,ACKR4,NPY,SAA1,MC2R,PLPPR1,WNT7A,PYY,ACKR3,PF4,CYSLTR2,UTS2,WNT6,HCRTR1,HTR1A,BDKRB2,CXCL5,NPBWR2,WNT2,UCN,CCL23,RGR,CHRM4,GPER1,CCL1,PNOC,TAS2R20,PTAFR,CCL28,GNG5,SMO,NTSR1,CCR5,OXT,LPAR3,LTB4R,MC3R,GPBAR1,MCHR2,CCKBR,EDN2,P2RY11,GNG13,MC1R,GPR31,P2RY6,CNR2,CHRM5,AGTR1,TAS2R50,EDNRA,WNT3,PRLH,HRH4,CALCR,ADORA1,CHRM2,OPN5,FFAR4,GRM4,DRD3,NTS,ADRA2C,P2RY2,LPAR5,P2RY13,FZD3,GALR3,CHRM3,NMBR,WNT1,P2RY1,NPBWR1,ADRA2A,WNT9B,HCRTR2,PENK,PMCH,GLP1R,CCRL2,INSL5,NPFFR2,CRHR1,FSHR,PPY,ADORA3,APP,INSL3,CCL27,SCT,EDN3,C3AR1,CCL16,CNR1,F2RL1,XCR1,AGT,CHRM1,GHRL,GNG7,TAAR1,GRP,CCK,SSTR3,MCHR1,GPR37,MC4R,TAS2R5,GNB5,CCL20,KNG1,TRHR,TAS2R9,TAS2R13,RLN3,NMUR1,SHH,FPR1,ADGRE5,WNT10B,NPY5R,SSTR1,GPR37L1,GPR39,ADRA1A,OPRK1,GNRH2,GPRC6A,RAMP1,PTHLH,CCKAR,TAC1,OPRD1,CXCR2,PTGER1,CX3CR1,OPN1SW,TAAR8,TAS2R60,CCL13,GLP2R,PTGER3,NPB,C5,NPSR1,GPR68,GNG10,PTGDR,GRM7,NMU,FPR2,CCR1,PTCH1,FFAR3,CXCL1,NMS,HTR4,TAAR5,WNT10A,P2RY12,HEBP1,CGA,RRH,PTGER2,CXCR1,AVP,GNG8,PTCH2,CCR8,ADRB2,GNB3,PROK2,C5AR2,SSTR5,NPY2R,C3,POMC,ADGRE1,TAS2R1,SSTR2,CCL25,HTR1E,GNRHR,GRM8,TAC3,QRFP,MTNR1A,TAS2R41,FPR3,CXCL10,ECE2,TACR2,MLNR,HRH1,HTR7,TBXA2R,TACR1,ADGRE3,GNB4,CCR4,GRM2,TAS2R4,DRD1,CRHR2,TAAR3P,CCL5,PLPPR3,F2R,FSHB,HRH2,GNG12,PTGIR,PSAP,KISS1,NTSR2,QRFPR,ADRA1D,HTR5A,GNGT1,GPR183,TAS1R2,GPHA2,RLN2,LHB,RXFP1,OPRL1,OPN4,GNRH1,CASR,FZD1,ADRA2B,NPY4R,CXCL11,DHH,TAS2R10,NLN,WNT2B,FZD6,DRD5,KISS1R,GRM6,XCL2,TAS2R19,S1PR2,PLPPR2,GCG,BDKRB1,CRH,GRM5,TSHR,DRD4,SCTR,TAS1R1,TAS2R46,CCR2,LHCGR,RHO,FFAR2,GCGR,CCR9,MLN,GALR2,SST,TAAR2,GPR18,S1PR5,CXCL6,PRLHR,TAS2R38,GALR1,HCAR2,WNT11,CALCA,CCR7,FZD4,ADORA2A,WNT9A,WNT3A,CORT,CCR6,TSHB,TRH,CRHBP,CXCL8,MC5R,PLPPR5,CXCR6,CCR3,GRM3,DRD2,FZD9,CD55,UCN3,HTR6,OPRM1,TAS2R3,GNG11,NPY1R,CXCL16,PTGFR,FZD8,ADCYAP1,ADM,ADGRE2,RAMP2,EDNRB,GNAS,LPAR6,XCL1,F2,WNT5A,CX3CL1,GRM1,TAS2R16,PLPPR4,ECE1,GNGT2,RXFP3,HTR1F,PTGER4,CALCRL,LPAR1,CXCL13,CCR10,TAAR6,ADORA2B,GNB1,TAS1R3,PTH,ADRA1B,HTR2A,GNG2,KEL,TAS2R39,RXFP4,UTS2B,WNT7B,S1PR4,ACKR1,GHRHR,PROKR2,RXFP2,FZD2,GIP,GPR65,PROKR1,C5AR1,UTS2R,FZD10,UCN2,OXER1,F2RL2,GIPR,FFAR1,NPS,AVPR1A,GABBR2,SSTR4,CCL19,EDN1,GNG4,HTR1D,P2RY14,PDYN,HTR1B,PTH2R,IAPP,MTNR1B,HCRT,ADRB3,OPN3,WNT4,TAS2R43,CALCB,PTH1R,GPR55,TAS2R7,WNT8A,FZD5,PTH2,CXCL2,WNT8B,S1PR3,PTGDR2,CCL21,NMUR2,CXCL12,GPHB5,GHRH,RAMP3,GPR35,OXTR,GNB2,NPFFR1,CXCR4,ADCYAP1R1,TAS2R31,OXGR1,SUCNR1,IHH,TACR3,S1PR1,GAL,ANXA1,GHSR,ADRB1,WNT16,TAS2R40
R-HSA-109582	Hemostasis	0.00405041870577124	-5.50893501906641	632	576	0.0637591321673677	9034	10285	6281,113220,23414,5153,1950,84876,1794,1521,285643,6786,285,1607,2782,5908,3845,30846,5670,55083,747,11069,5552,23428,8503,146909,3046,54331,29106,7423,8354,5879,84643,2814,1439,5175,5005,483,5197,64145,3440,1191,3796,23468,11136,6814,5026,56301,88,7157,3660,2151,89953,22920,6520,5025,22927,124602,4893,3818,2153,2734,6717,5573,813,7044,5340,3685,634,5527,2767,78991,2786,50848,6850,857,10630,5269,10235,1072,2268,5529,2769,3512,3834,6693,7525,140885,10362,7450,100616400,5267,1525,5781,3043,5768,374354,3674,1608,3448,11004,197,3705,54676,7873,490,7056,1020,346562,3779,6678,66005,5657,4602,120425,25,2152,83700,10490,972,207,7414,5678,5155,27154,9732,51378,3309,23348,5576,1437,10938,5152,487,226,3683,3778,4973,8832,5575,7123,80228,10487,1675,100616453,2243,5136,4282,2783,2155,3082,2625,1609,4312,5590,7422,5023,3562,9585,8526,5528,2768,2626,1084,29127,8525,7035,140628,3449,5874,3717,25942,6915,7441,7534,59345,5293,5594,10000,5335,5770,2149,30845,334,10242,2162,5336,5660,5777,3456,55970,5739,5104,3659,9564,4842,1048,3710,23533,4352,23186,2792,7804,9123,58494,5291,3452,126961,25970,51744,1062,350,9672,4846,23657,29802,7410,12,5327,23028,151,9493,6654,51706,2165,55619,5588,2335,8968,5547,8358,10184,9749,2770,9056,6547,5868,11343,808,55604,5515,338,7040,4778,5270,387,1445,10447,5516,481,23759,50808,3718,2885,928,5296,5054,3021,6810,23539,8797,5329,962,5295,87,5140,1088,6714,10112,51317,3932,55605,8350,5328,5580,6404,57572,2791,57406,3444,960,146850,27094,2778,5669,2147,83953,2161,2817,51266,6566,8357,4067,2994,55669,51097,5566,81930,2793,7273,10544,5894,7465,2888,302,5889,491,10461,4680,8515,801,3827,7043,10681,3716,8793,967,2207,10451,3020,54210,5518,3672,23764,6813,3832,284,22915,23052,5680,8140,2624,5271,3479,221458,10125,3676,7277,5583,7424,406974,3959,8353,10257,10672,2776,3675,5624,2160,55664,1017,3835,6546,3690,2811,9057,5154,1793,7010,5519,2790,5568,5581,221037,2982,26090,8165,11216,8352,6647,5290,5024,5582,26153,55423,90952,965,208,10846,10411,7222,1398,830,2534,10603,3635,3699,64805,27040,64147,94235,3684,8795,3439,2983,3053,2244,2784,3558,7042,23095,7018,55614,5880,408,51206,2771,6543,3937,23303,85440,3559,10749,3831,5321,3655,1795,3671,135228,3833,6694,7225,23046,54495,5004,5567,147700,2815,3673,488,5919,8355,9927,3265,8654,832,9630,2773,1606,27345,7409,5099,3568,5170,3445,3708,100302237,11127,51571,3481,11311,83706,440533,5579,710,335,5675,2995,10335,5196,2977,81704,2159,1387,161882,6464,5676,4099,3047,5139,160851,10019,5345,961,391,9046,682,5578,3797,5138,9463,5672,6414,5027,5478,998,3709,5526,9162,2787,3665,6402,482,57113,653604,5294,5593,9846,3687,9948,5525,5055,3273,3442,6383,3441,3689,2,5265,213,221955,5627,51764,308,8407,7057,462,7078,2993,1893,3567,6401,5673,5747,5906,3700,3799,388,5592,3543,55582,3560,6403,493,5671,3048,81,152,51368,3066,3443,6382,914,81928,29789,4072,1432,54518,7975,64837,3065,56992,6385,4097,5028,489,3798,5341,150,5595,948,2033,5577,50940,351,805,547,80005,3688,5890,409,3661,5216,2266,259215,5051,8527,2788	S100A10,KIF12,ZFPM2,PDE1B,EGF,ORAI1,DOCK2,CTSW,KIF4B,STIM1,ANGPT2,DGKB,GNB1,RAP1B,KRAS,EHD2,PSG2,KIF26B,DAGLA,RAPGEF4,SRGN,SLC7A8,PIK3R3,KIF18B,HBE1,GNG2,SCG3,VEGFB,H3C11,RAC1,KIF2B,GP5,CSF2RB,PECAM1,ORM2,ATP1B3,PF4V1,RBSN,IFNA2,CLU,KIF2A,CBX5,SLC7A9,STXBP3,P2RX5,SLC7A10,ACTN2,TP53,IRF2,F2RL2,KLC4,KIFAP3,SLC3A2,P2RX4,HABP4,KIF19,NRAS,KLKB1,F5,GLG1,SRI,PRKAR1A,CALU,LEFTY2,PLG,ITGAV,CEACAM1,PPP2R5C,GNA11,PCYOX1L,GNG4,F11R,SYK,CAV1,PDPN,SERPINB6,RASGRP2,CFL1,FGR,PPP2R5E,GNA15,JCHAIN,KIF25,SPN,YES1,SIRPA,HMG20B,VWF,MIR3198-2,SERPINA4,CXADR,PTPN11,HBB,QSOX1,NHLRC2,ITGA2B,DGKG,IFNA14,KIF2C,AHSG,ITPK1,GTPBP2,MANF,ATP2B1,THBD,CDK5,GNAT3,KCNMB1,SPARC,CHID1,PRTN3,MYB,JAML,ABL1,F3,JAM3,VTI1B,CD74,AKT1,VCL,PSG9,PDGFB,BRPF3,DOCK4,ANGPT4,HSPA5,DOCK9,PRKAR2A,CSF2,EHD1,PDE9A,ATP2A1,ALDOA,ITGAL,KCNMA1,OLR1,CD84,PRKAR1B,CLEC3B,ORAI2,CAP1,CFD,MIR4687,FGA,PDE1A,MIF,GNB2,F7,HGF,GATA3,DGKQ,MMP1,PRKCZ,VEGFA,P2RX1,IL3,KIF20B,DGKE,PPP2R5D,GNA12,GATA4,CEACAM3,RACGAP1,DGKZ,TFPI,GATA5,IFNA16,RAB27B,JAK2,SIN3A,TBXA2R,VPREB1,YWHAZ,GNB4,PIK3CD,MAPK1,AKT3,PLCG1,PTPN1,F2R,EHD3,APLP2,KCNMB2,F13A1,PLCG2,PSAP,PTPN6,IFNB1,GNG12,PTGIR,SERPINA5,IRF1,BCAR1,NOS1,CEACAM5,ITPR3,PIK3R5,MPL,RCOR1,GNGT1,LRP8,SLC16A3,JAM2,PIK3CB,IFNA21,H3C14,SH2B1,CD244,CENPE,APOH,SDC3,NOS3,SLC7A11,VPREB3,VAV2,SERPINA3,PLAT,KDM1A,ADRA2B,KIF23,SOS1,CYB5R1,F13B,DOCK10,PRKCQ,FN1,H3C7,PRCP,H3C2,LHFPL2,PHACTR2,GNAI1,SLC7A7,SLC8A3,RAB5A,MGLL,CALM3,CARMIL1,PPP2CA,APOB,TGFB1,NFE2,SERPINE2,RHOA,CSK,FAM3C,PPP2CB,ATP1B1,PPIL2,AK3,JAK3,GRB2,CD9,PIK3R2,SERPINE1,H3-3B,STX4,SLC16A8,TNFRSF10A,PLAUR,CD48,PIK3R1,ACTN1,PDE3B,CEACAM8,SRC,KIF20A,PHF21A,LCK,KIF21A,H3C1,PLAU,PRKCD,SELPLG,DOCK6,GNG11,ABHD6,IFNA7,CD44,PIK3R6,KCNMB3,GNAS,PSG1,F2,FCAMR,F12,GPC1,CLEC1B,SLC16A1,H3C10,LYN,GYPB,MFN1,SCCPDH,PRKACA,KIF18A,GNGT2,TTN,PROCR,RAF1,WEE1,GRB14,ANXA2,RAD51C,ATP2B2,MERTK,CEACAM6,ITGA10,CALM1,KNG1,TGFB3,GNB5,JAK1,TNFRSF10D,CD63,FCER1G,VAV3,H3-3A,TREM1,PPP2R1A,ITGA1,MAFF,STXBP2,KIF11,ANGPT1,MMRN1,ENDOD1,PSG11,SLC7A5,GATA2,SERPINB8,IGF1,KIF6,RASGRP1,ITGA4,TUBA4A,PRKCH,VEGFC,MIR197,LGALS3BP,H3C6,ABCC4,GNA13,GNAQ,ITGA3,PROC,F11,CDC37L1,CDK2,KIF22,SLC8A1,ITGB3,GP1BA,SLC7A6,PDGFA,DOCK1,TEK,PPP2R1B,GNG10,PRKACG,PRKCE,JMJD1C,GUCY1A1,ABHD12,AKAP1,AKAP10,H3C3,SOD1,PIK3CA,P2RX3,PRKCG,KIF26A,SIRPG,ESAM,CD58,AKT2,PDE10A,RAPGEF3,TRPC3,CRK,CAPZA2,FYN,SH2B2,INPP5D,ITIH3,P2RY12,LAT,KIF9,GNG8,ITGAM,TNFRSF10B,IFNA1,GUCY1B1,SERPIND1,FGB,GNB3,IL2,TGFB2,KIF1B,TF,KIF16B,RAC2,ARRB1,GP6,GNAI2,SLC8A2,LCP2,KIF13B,DOCK7,IL2RA,KIF1C,KLC1,PLA2G4A,ITGA6,DOCK3,ISLR,CD109,KIFC1,SPP2,TRPC6,KIF21B,TMX3,ORM1,PRKACB,KLC3,GP9,ITGA2,ATP2A2,RARRES2,H3C8,MFN2,HRAS,PDE5A,CAPZB,GNA14,GNAI3,DGKA,KCNMB4,VAV1,PCDH7,IL5RA,PDPK1,IFNA8,ITPR1,MIR1281,KIF3A,CYRIB,IGF2,VPS45,FERMT3,PSG8,PRKCB,SERPING1,APOA1,PSG6,GYPC,IRAG1,PF4,GUCY1A2,DOCK8,F10,CREBBP,ZFPM1,SHC1,PSG7,MAG,HBG1,PDE3A,DGKH,SH2B3,SERPINF2,CD47,RHOG,DOK2,BSG,PRKCA,KIF3C,PDE2A,PICK1,PSG4,SELENOP,P2RX7,PPIA,CDC42,ITPR2,PPP2R5B,DGKI,GNG5,IRF7,SELL,ATP1B2,TRPC7,H3C13,PIK3CG,PRKG2,GAB2,ITGAX,WDR1,PPP2R5A,SERPINB2,HRG,IFNA5,SDC2,IFNA4,ITGB2,A2M,SERPINA1,ALB,DAGLB,PROS1,GNG13,ANXA5,TAGLN2,THBS1,SERPINC1,TIMP3,GYPA,ECM1,IL5,SELE,PSG5,PTK2,RAP1A,ITIH4,KIF5B,RHOB,PRKG1,IGLL1,KIF27,IL2RB,SELP,ATP2B4,PSG3,HBG2,ACTN4,ADRA2C,TEX264,HDAC2,IFNA6,SDC1,CD2,CABLES2,OLA1,EPCAM,MAPK14,APBB1IP,MAFK,KLC2,HDAC1,KIF15,SDC4,MAFG,P2RY1,ATP2A3,KIF5A,PLEK,ADRA2A,MAPK3,CD36,EP300,PRKAR2B,PDE11A,APP,CALM2,KIF1A,DOCK5,ITGB1,RAD51B,ARRB2,IRF3,PFN1,FGG,LY6G6F,PAFAH2,DGKD,GNG7
R-HSA-166520	Signalling by NGF	0.00445269221835575	-5.41424637284948	477	437	0.0483728138144786	9034	10285	814,2252,1843,284,4790,57731,940,9639,5604,5305,55615,5894,8817,5687,6709,801,23365,3716,7189,10451,7867,5728,5518,8841,6708,3690,10048,5154,283455,2889,7010,1147,3084,5519,9826,53358,5581,5568,5708,115727,57449,10125,192669,4615,10672,942,2255,114,3164,6016,54756,29851,1759,161,8074,27040,2065,8660,4974,5720,2244,100271715,2066,818,23263,3558,5290,5582,1846,9693,23239,100847012,64096,8874,208,1398,2534,57761,5707,221472,6233,5567,2253,196883,3265,5694,121512,8682,4804,4233,408,10276,3559,4208,7074,5700,192670,9365,11108,28956,25780,2251,8315,6195,396,107,26523,1839,1956,5899,6464,6196,4099,27327,10156,5704,50650,22899,221002,7409,930,163,3568,5170,3708,5690,6712,1742,5526,3709,5921,8870,9965,161742,2247,10768,2261,26574,83464,1173,5715,5525,84292,7529,5970,7984,2675,5898,112,55701,7316,5159,11214,10126,5578,2676,10197,5923,2903,10817,7531,2263,4747,3560,51107,3066,8394,27161,10213,1432,54518,5698,4193,6655,1026,5979,8452,3065,8822,51231,4763,3567,23370,2249,1850,8767,9462,5125,5922,64223,5906,5747,8826,4684,5607,6711,10142,2905,25791,409,1785,2266,2248,10718,2906,3815,23421,4914,5711,4902,4343,8997,842,153090,5137,152559,1175,5713,8878,5595,5577,26281,5600,5699,7311,5684,389337,805,8503,5599,109,5695,5584,5879,8831,23112,1385,5536,5696,29,10018,1439,5623,160,9542,5153,1950,5037,7249,5245,3845,50649,5908,113,5786,57498,815,51332,3667,55160,115,84335,685,5573,836,6014,5527,5717,117145,2064,2246,9861,143471,5710,7979,1844,6456,23198,7157,88,5598,5692,3643,2931,6710,7204,5603,122706,4893,9252,27237,84033,941,2475,128272,1213,2932,5156,5691,1027,26084,25759,207,11221,7414,5155,5900,8437,5719,5529,7450,5781,3674,2254,9181,1211,5693,4803,817,6453,6774,5605,3562,117,26052,5528,5718,84078,23396,5576,9048,1437,57580,5664,84904,4254,5575,2260,6199,2243,27006,5136,445328,79837,3082,4915,3710,5924,2904,84894,156,5291,2264,3717,5685,108,466,1848,10000,5594,5293,5335,5686,57690,6300,9261,6654,8396,2250,1849,2335,5701,6868,4792,8395,5682,253260,145957,200734,808,5045,9138,4205,9491,7410,5046,2069,89846,6610,135,5296,2309,816,26230,5714,3551,5295,50852,6714,111,3932,5515,7314,387,1445,4140,23035,80824,5702,5516,1847,3630,399473,3718,23385,4296,2885,2674,673,8649,2668,118788,5706,1894,5566,2549,9828,57142,5580,2308,64926,9978,10256,10818,116,79109,835	CAMK4,FGF7,DUSP1,ANGPT1,NFKB1,SPTBN4,CD28,ARHGEF10,MAP2K1,PIP4K2A,PRR5,RAF1,FGF18,PSMA6,SPTAN1,CALM1,ARHGEF12,JAK1,TRAF6,VAV3,MAPKAPK3,PTEN,PPP2R1A,HDAC3,SPTA1,ITGB3,RANBP9,PDGFA,KSR2,RAPGEF1,TEK,CHUK,NRG1,PPP2R1B,ARHGEF11,SHC3,PRKCE,PRKACG,PSMD2,RASGRP4,PLEKHG5,RASGRP1,AGO3,MYD88,GNA13,CD86,FGF10,ADCY8,NR4A1,RIT1,IL17RD,ICOS,DNM1,AP2A2,FGF23,LAT,ERBB3,IRS2,OMG,PSME1,FGB,ARHGEF33,ERBB4,CAMK2G,MCF2L,IL2,PIK3CA,PRKCG,DUSP4,RAPGEF2,PHLPP1,MIR5004,GFRA4,ARHGEF7,AKT2,CRK,FYN,TRIB3,PSMD1,FGD2,RPS27A,PRKACB,FGF8,ADCY4,HRAS,PSMB6,FGD4,PEA15,NGFR,MET,ARRB1,NET1,IL2RA,MEF2C,TIAM1,PSMC1,AGO4,KL,PRDM4,LAMTOR2,RASGRP3,FGF6,BRAP,RPS6KA1,ARHGDIA,ADCY1,AGO1,HBEGF,EGFR,RALB,SHC1,RPS6KA2,MAG,TNRC6A,RASA4,PSMC4,ARHGEF3,ARHGEF15,RASGEF1A,VAV1,CD19,AP2B1,IL5RA,PDPK1,ITPR1,PSMB2,SPTBN2,DLG4,PPP2R5B,ITPR2,RASA1,IER3,FGF19,SPRED1,FGF2,AHCYL1,FGFR3,AATF,APH1B,AP2M1,PSMD9,PPP2R5A,WDR83,YWHAB,RELA,ARHGEF5,GFRA2,RALA,ADCY6,ARHGEF40,UBC,PDGFRB,AKAP13,DNAL4,PRKCA,GFRA3,PSME3,RASGRF1,GRIN2A,FRS3,YWHAE,FGFR2,NEFL,IL2RB,APH1A,HDAC2,PIP5K1A,AGO2,PSMD14,MAPK14,APBB1IP,PSMB9,MDM2,SOS2,CDKN1A,RET,CUL3,HDAC1,FGF17,VRK3,NF1,IL5,ARHGEF18,FGF4,DUSP8,RIPK2,RASAL2,PCSK5,RASA2,MLST8,RAP1A,PTK2,IQGAP1,NCAM1,MAP2K5,SPTBN1,AKAP9,GRIN2C,NGEF,ARRB2,DNM2,FGG,FGF3,NRG3,GRIN2D,KIT,ITGB3BP,NTRK1,PSMD5,NRTN,MOV10,KALRN,CASP9,DAB2IP,PDE1C,PAQR3,AP2S1,PSMD7,SQSTM1,MAPK3,PRKAR2B,FGF20,MAPK11,PSMB10,UBA52,PSMA3,ARHGEF37,CALM2,PIK3R3,MAPK8,ADCY3,PSMB7,PRKCI,RAC1,SYNGAP1,TNRC6B,CREB1,PPP5C,PSMB8,ABR,BCL2L11,CSF2RB,PSPN,AP2A1,NRG2,PDE1B,EGF,PEBP1,TSC2,PHB1,KRAS,ARHGEF4,RAP1B,ADCY7,PTPRA,KIDINS220,CAMK2A,SPTBN5,IRS1,ARHGEF10L,ADCY9,AKT1S1,BTC,PRKAR1A,CASP3,RIT2,PPP2R5C,PSMD11,THEM4,ERBB2,FGF1,PSMD6,PSMA8,PSMD4,SEM1,DUSP2,SH3GL2,PSME4,TP53,ACTN2,MAPK7,PSMB4,INSR,GSK3A,SPTB,TRIO,MAPK13,PSMB11,NRAS,RPS6KA5,ARHGEF16,OBSCN,CD80,MTOR,ARHGEF19,CLTC,GSK3B,PDGFRA,PSMB3,CDKN1B,ARHGEF26,SHC2,AKT1,DUSP10,VCL,PDGFB,RALGDS,RASAL1,PSMD13,PPP2R5E,VWF,PTPN11,ITGA2B,FGF9,ARHGEF2,CLTA,PSMB5,NGF,CAMK2D,ITSN1,STAT3,MAP2K2,IL3,ADCYAP1R1,DNM3,PPP2R5D,PSMD12,KBTBD7,PIP5K1C,PRKAR2A,ARTN,CSF2,PREX1,PSEN2,ARHGEF39,KITLG,PRKAR1B,FGFR1,RPS6KB2,FGA,FGF22,PDE1A,ARHGEF35,PIP4K2C,HGF,NTRK2,ITPR3,RASGRF2,GRIN2B,LINGO1,GRK2,PIK3CB,FGFR4,JAK2,PSMA4,ADCY2,ATF1,DUSP6,AKT3,MAPK1,PIK3CD,PLCG1,PSMA5,TNRC6C,MAPK12,MAPKAPK2,SOS1,PIP4K2B,FGF5,DUSP7,FN1,PSMC2,ADAM17,NFKBIA,PIP5K1B,PSMA1,RICTOR,NRG4,SPRED2,CALM3,FURIN,ARHGEF1,MEF2A,PSMF1,VAV2,PCSK6,EREG,FGD3,SMPD2,ADORA2A,PIK3R2,FOXO3,CAMK2B,TIAM2,PSMD8,IKBKB,PIK3R1,TRAT1,SRC,ADCY5,LCK,PPP2CA,UBB,RHOA,CSK,MARK3,PHLPP2,DUSP16,PSMC3,PPP2CB,DUSP5,INS,SPRED3,JAK3,NCSTN,MAP3K11,GRB2,GFRA1,BRAF,LAMTOR3,GDNF,PIK3AP1,PSMC6,ECT2,PRKACA,GAB1,ARHGEF17,RTN4,PRKCD,FOXO1,RASAL3,RBX1,CNKSR1,FRS2,ADCYAP1,MAPKAP1,CASP2
R-HSA-1296071	Potassium Channels	0.00447570407034374	-5.40909160547601	100	96	0.0106265220278946	9034	10285	7881,6833,51305,338567,56479,3742,3779,3752,3737,9424,90134,9132,3784,94235,54207,3736,3764,2784,9312,170850,23415,3756,23416,610,3778,8514,3755,3757,27094,3763,2783,26290,3761,83795,3788,3745,3773,3747,3768,3781,2793,169522,3746,2788,89822,27345,2550,3782,3754,2782,56659,3762,10021,10242,3749,3772,131096,3759,55970,54331,10060,3744,348980,2792,9196,27133,3738,3776,50801,3780,26251,3758,3777,10089,3743,3739,3775,3760,81033,3751,27012,3790,3741,3770,2787,3767,9568,3786,3765,2786,3748,3785,2790,3766,3787,93107	KCNAB1,ABCC8,KCNK9,KCNK18,KCNQ5,KCNA6,KCNMB1,KCND3,KCNA2,KCNK6,KCNH7,KCNQ4,KCNQ1,GNG8,KCNK10,KCNA1,KCNJ8,GNB3,KCNB2,KCNG3,KCNH4,KCNH1,KCNH3,HCN2,KCNMA1,KCNAB2,KCNG1,KCNH2,KCNMB3,KCNJ6,GNB2,GALNT8,KCNJ4,KCNK16,KCNS2,KCNB1,KCNJ16,KCNC2,KCNJ12,KCNN2,GNGT2,KCNV2,KCNC1,GNG7,KCNK17,KCNMB4,GABBR1,KCNN3,KCNF1,GNB1,KCNK13,KCNJ5,HCN4,KCNMB2,KCNC4,KCNJ15,KCNH8,KCNJ2,GNG12,GNG2,ABCC9,KCNA10,HCN1,GNGT1,KCNAB3,KCNH5,KCNA3,KCNK2,KCNK4,KCNN1,KCNG2,KCNJ1,KCNK3,KCNK7,KCNA7,KCNA4,KCNK1,KCNJ3,KCNH6,KCND2,KCNV1,KCNS3,KCNA5,KCNJ14,GNG5,KCNJ11,GABBR2,KCNQ3,KCNJ9,GNG4,KCNC3,KCNQ2,GNG10,KCNJ10,KCNS1,KCNG4
R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	0.0049516919723162	-5.30802594821702	86	83	0.00918751383661722	9034	10285	7525,3071,7409,5290,5594,917,919,5337,3708,5335,4620,63916,4651,1398,10094,5338,23191,23646,3320,5336,5747,10006,2885,10451,2534,7456,8936,9844,644150,5296,5879,122618,4650,10093,25,4690,4641,10152,6714,5295,3710,26999,3326,5291,4627,5580,10458,3984,10097,55845,51517,10810,84513,10095,10092,7410,5595,71,8976,10096,998,2214,10163,9103,147179,5058,10552,2209,3709,10109,10787,8398,10768,1793,6850,2212,196051,4067,60,1072,2268,4644,5581	YES1,NCKAP1L,VAV1,PIK3CA,MAPK1,CD3G,CD247,PLD1,ITPR1,PLCG1,MYH2,ELMO2,MYO10,CRK,ARPC3,PLD2,CYFIP1,PLD3,HSP90AA1,PLCG2,PTK2,ABI1,GRB2,VAV3,FYN,WIPF1,WASF1,ELMO1,WIPF3,PIK3R2,RAC1,PLD4,MYO9B,ARPC4,ABL1,NCK1,MYO1C,ABI2,SRC,PIK3R1,ITPR3,CYFIP2,HSP90AB1,PIK3CB,MYH9,PRKCD,BAIAP2,LIMK1,ACTR2,BRK1,NCKIPSD,WASF3,PLPP5,ARPC1B,ARPC5,VAV2,MAPK3,ACTG1,WASL,ACTR3,CDC42,FCGR3A,WASF2,FCGR2C,WIPF2,PAK1,ARPC1A,FCGR1A,ITPR2,ARPC2,NCKAP1,PLA2G6,AHCYL1,DOCK1,SYK,FCGR2A,PLPP4,LYN,ACTB,CFL1,FGR,MYO5A,PRKCE
R-HSA-1433557	Signaling by SCF-KIT	0.0049761503154554	-5.3030987159116	337	311	0.0344255036528669	9034	10285	1950,6709,5037,7249,801,5245,55615,5894,9542,8817,5687,2242,51332,815,5518,5728,3716,1111,3845,5908,1215,5786,6776,1843,284,5879,23112,8831,1385,8503,2252,5695,5623,5604,5305,9306,5536,57731,5696,940,1439,6772,192669,7979,1844,23198,7157,88,143471,5710,10125,6710,122706,4893,5692,942,3643,2931,2255,84335,685,7010,3667,6708,3690,5154,10048,283455,2246,53358,9861,5708,115727,5717,1147,5527,3084,5519,117145,2064,5781,100847012,3674,64096,2254,5719,5529,5290,9693,7450,1846,7525,23239,2534,5693,57761,2887,10603,817,208,2932,5156,27040,5691,8074,2065,8660,10076,1027,3164,54756,29851,8651,941,2475,818,2066,7414,5155,3558,8437,5720,25759,207,2244,11221,408,4233,9048,1437,28956,2251,25780,79837,3082,3559,4254,5700,2260,6199,2243,9365,27006,192670,2253,5718,5528,5707,2241,6774,6233,5605,3562,84078,5694,23396,8682,3265,1848,930,5170,3568,4318,5293,10000,5594,3717,5685,221002,7409,6712,1742,5686,57690,5690,1839,1956,5777,8315,26523,6777,27327,10156,5291,2264,5704,6464,5924,2904,5159,7316,5578,2675,10019,2069,10817,2263,9491,10197,2676,5923,2903,161742,2247,2335,2261,9402,5701,9846,6654,5526,5921,8870,8396,1849,2250,9965,200734,808,8395,5715,5525,5682,253260,84292,145957,7529,1445,4140,23035,80824,5515,8822,867,7314,2249,1850,9462,5922,3718,4296,2674,5906,64223,2885,5747,5702,5516,1847,4763,399473,3630,3567,2309,816,8394,5714,27161,4747,5296,3560,54518,5698,4193,3932,1026,5979,8452,5295,10213,50852,6714,64926,152559,9978,5713,10256,4902,4343,153090,842,2308,79109,5684,805,10818,5595,400581,26281,5699,7311,2668,10142,2905,118788,409,8826,4684,673,6711,8649,2549,2906,3815,10750,5711,5706,2266,4067,2248,10718	EGF,SPTAN1,PEBP1,TSC2,CALM1,PHB1,PRR5,RAF1,NRG2,FGF18,PSMA6,FES,SPTBN5,CAMK2A,PPP2R1A,PTEN,JAK1,CHEK1,KRAS,RAP1B,CMA1,PTPRA,STAT5A,DUSP1,ANGPT1,RAC1,TNRC6B,SYNGAP1,CREB1,PIK3R3,FGF7,PSMB7,PSPN,MAP2K1,PIP4K2A,SOCS6,PPP5C,SPTBN4,PSMB8,CD28,CSF2RB,STAT1,AGO3,SEM1,DUSP2,PSME4,TP53,ACTN2,PSMA8,PSMD4,RASGRP1,SPTB,PSMB11,NRAS,PSMB4,CD86,INSR,GSK3A,FGF10,AKT1S1,BTC,TEK,IRS1,SPTA1,ITGB3,PDGFA,RANBP9,KSR2,FGF1,SHC3,PSMD6,PSMD2,RASGRP4,PSMD11,CHUK,PPP2R5C,NRG1,PPP2R1B,THEM4,ERBB2,PTPN11,MIR5004,ITGA2B,GFRA4,FGF9,PSMD13,PPP2R5E,PIK3CA,RAPGEF2,VWF,DUSP4,YES1,PHLPP1,FYN,PSMB5,TRIB3,GRB10,SH2B2,CAMK2D,AKT2,GSK3B,PDGFRA,LAT,PSMB3,FGF23,ERBB3,IRS2,PTPRU,CDKN1B,NR4A1,IL17RD,ICOS,SOCS1,CD80,MTOR,CAMK2G,ERBB4,VCL,PDGFB,IL2,RASAL1,PSME1,SHC2,AKT1,FGB,DUSP10,ARRB1,MET,ARTN,CSF2,LAMTOR2,FGF6,RASGRP3,PIP4K2C,HGF,IL2RA,KITLG,PSMC1,FGFR1,RPS6KB2,FGA,KL,FGF22,AGO4,FGF8,PSMD12,PPP2R5D,PSMD1,FER,STAT3,RPS27A,MAP2K2,IL3,KBTBD7,PSMB6,PIP5K1C,PEA15,HRAS,DUSP6,CD19,PDPK1,IL5RA,MMP9,PIK3CD,AKT3,MAPK1,JAK2,PSMA4,RASGEF1A,VAV1,SPTBN2,DLG4,PSMA5,TNRC6C,PSMB2,HBEGF,EGFR,PTPN6,BRAP,AGO1,STAT5B,TNRC6A,RASA4,PIK3CB,FGFR4,PSMC4,SHC1,RASGRF2,GRIN2B,PDGFRB,UBC,PRKCA,GFRA2,SH2B3,EREG,FRS3,FGFR2,PSMF1,PSME3,GFRA3,RASGRF1,GRIN2A,SPRED1,FGF2,FN1,FGFR3,GRAP2,PSMC2,GAB2,SOS1,PPP2R5B,RASA1,IER3,PIP4K2B,DUSP7,FGF5,FGF19,SPRED2,CALM3,PIP5K1B,PSMD9,PPP2R5A,PSMA1,RICTOR,WDR83,NRG4,YWHAB,CSK,MARK3,PHLPP2,DUSP16,PPP2CA,FGF17,CBL,UBB,FGF4,DUSP8,RASAL2,RASA2,JAK3,MAP3K11,GFRA1,RAP1A,MLST8,GRB2,PTK2,PSMC3,PPP2CB,DUSP5,NF1,SPRED3,INS,IL5,FOXO3,CAMK2B,PIP5K1A,PSMD8,AGO2,NEFL,PIK3R2,IL2RB,APBB1IP,PSMB9,MDM2,LCK,CDKN1A,RET,CUL3,PIK3R1,PSMD14,TRAT1,SRC,RASAL3,PAQR3,RBX1,PSMD7,CNKSR1,NRTN,MOV10,DAB2IP,CASP9,FOXO1,MAPKAP1,PSMA3,CALM2,FRS2,MAPK3,GRAPL,FGF20,PSMB10,UBA52,GDNF,AKAP9,GRIN2C,PIK3AP1,ARRB2,IQGAP1,NCAM1,BRAF,SPTBN1,LAMTOR3,GAB1,GRIN2D,KIT,GRAP,PSMD5,PSMC6,FGG,LYN,FGF3,NRG3
R-HSA-211859	Biological oxidations	0.00557589815640596	-5.18930187032379	222	207	0.0229134381226478	9034	10285	218,1572,6820,126,389396,26,10858,54579,10499,1544,2938,10327,10249,1582,1727,217,2686,10941,55748,5447,494143,6819,116285,2949,11283,285440,2052,124975,1586,4835,6916,7358,2230,57834,1553,84532,112812,55347,9915,1585,2098,79017,10728,2948,4257,8529,1576,54600,51000,2327,7365,3326,54576,64757,1543,64174,126410,1312,22977,100861540,1066,2939,8824,7366,27284,2937,25830,1584,191,113612,57491,134147,4548,27233,100616414,54659,4259,9,7364,9060,29104,100616124,27306,64180,133688,4258,51302,6817,2947,1545,2950,1573,54905,123876,7363,91703,2730,8648,1581,10720,84836,56603,27430,1583,7172,196,1555,66002,2328,2940,8639,5740,54996,574537,1592,2232,1559,9061,216,2944,79799,128,9420,131,219970,9446,219,2954,57412,54490,23491,1562,2687,4144,1549,127,405,167127,64816,4837,1565,10,2729,2953,13,6822,341392,2941,4552,348158,4143,1548,54657,91227,221357,284541,373156,7360,1580,54578,874,6256,1558,1577,1595,51504,79094,2326,670,95,124,1579,119391,23169,1800,2952,29785,9971,2678,314,5443,120227,1836,6799,246181,1589,54498,1594,130,5742,125,10380,10861,347734,92292,1593,1588,54658,2946,80777,55902,2679,54577,6783,1557,1591,9049	ALDH3A1,CYP2F1,SULT2B1,ADH1C,GLYATL3,AOC1,CYP46A1,UGT1A5,NCOA2,CYP1A2,GSTA1,AKR1A1,GLYAT,CYP8B1,CYB5R3,ALDH2,GGT7,UGT2A1,CNDP2,POR,CHAC2,SULT1C2,ACSM1,GSTM5,CYP4F8,CYP4V2,EPHX1,GGT6,CYP17A1,NQO2,TBXAS1,UGDH,FDX1,CYP4F11,CYP2A13,ACSS1,FDX2,ABHD10,ARNT2,CYP11B2,ESD,GGCT,PTGES3,GSTM4,MGST1,CYP4F2,CYP3A4,UGT1A9,SLC35B3,FMO2,UGT2B10,HSP90AB1,UGT1A8,MTARC1,CYP1A1,DPEP2,CYP4F22,COMT,AKR7A3,CYP3A7-CYP3A51P,CES1,GSTA2,CES2,UGT2B15,SULT1B1,GSS,SULT4A1,CYP11B1,AHCY,CYP2U1,AHRR,CMBL,MTR,SULT1C4,MIR4761,UGT1A3,MGST3,NAT1,UGT2B7,PAPSS2,N6AMT1,MIR4647,HPGDS,DPEP3,UGT3A1,MGST2,CYP39A1,SULT1A1,GSTM3,CYP1B1,GSTP1,CYP2J2,CYP2W1,ACSM2A,UGT2B4,ACY3,GCLM,NCOA1,CYP7A1,UGT2B11,ABHD14B,CYP26B1,MAT2B,CYP11A1,TPMT,AHR,CYP2B6,CYP4F12,FMO3,GSTA3,AOC3,PTGIS,MTARC2,UGT2A2,CYP26A1,FDXR,CYP2C9,PAPSS1,ALDH1A1,GSTM1,UGT2A3,ADH5,CYP7B1,ADH7,GLYATL2,GSTO1,ALDH1B1,GSTZ1,AS3MT,UGT2B28,CES3,CYP2C18,GGT5,MAT2A,CYP2A7,ADH4,ARNT,UGT3A2,CYP3A43,NNMT,CYP2D6,NAT2,GCLC,GSTT2,AADAC,SULT2A1,ACSM4,GSTA4,MTRR,ACSM2B,MAT1A,CYP2A6,UGT1A4,GGTLC2,GSTA5,CYP4A22,GSTK1,UGP2,CYP4B1,UGT1A6,CBR3,RXRA,CYP2C8,CYP3A5,CYP51A1,TRMT112,CHAC1,FMO1,BPHL,ACY1,ADH1A,CYP4A11,GSTO2,SLC35D1,DPEP1,GSTT1,CYP2S1,NR1H4,GGT1,AOC2,POMC,CYP2R1,SLC26A2,SULT1A2,AKR7L,CYP21A2,SMOX,CYP27B1,ADH6,PTGS1,ADH1B,BPNT1,SLC26A1,SLC35B2,GLYATL1,CYP27A1,CYP19A1,UGT1A1,GSTM2,CYB5B,ACSS2,GGT3P,UGT1A7,SULT1E1,CYP2C19,CYP24A1,AIP
R-HSA-2172127	DAP12 interactions	0.00675249406541466	-4.99784335117021	371	341	0.037746291786584	9034	10285	7311,5699,26281,5577,3824,10818,5595,805,5684,79109,124599,2308,153090,842,5580,4343,4902,10256,5713,9978,152559,7305,64926,5137,10718,5566,2248,2266,5706,5711,3815,2906,2549,8649,6711,673,4684,8826,409,118788,2905,2668,10142,3567,3630,399473,4763,1847,5516,5702,100528032,5747,5906,64223,2885,2674,4296,5922,3718,9462,1850,2249,342510,7314,8822,5515,80824,23035,4140,3107,1445,111,6714,50852,10213,5295,8452,5979,1026,3932,4193,54518,5698,3560,5296,4747,27161,5714,8394,816,2309,7410,2903,5923,2676,10197,9491,2263,284266,10817,2069,112,2675,5578,7316,5159,145957,7529,253260,84292,5682,5715,5525,8395,808,200734,9965,2250,1849,8870,8396,5921,5526,3709,6654,9402,5701,2261,2335,10768,161742,2247,100049587,5690,57690,5686,5336,1742,6712,3133,7409,221002,108,5685,3717,5335,10000,5594,5293,3708,5170,3568,930,1848,2904,23601,5924,6464,3710,5704,5291,2264,10156,27327,156,26523,107,8315,1956,1839,27006,9365,192670,2243,400709,6199,2260,5700,5575,3559,4254,3082,79837,2251,28956,25780,5136,1437,9048,5576,4233,3937,408,3265,22914,8682,23396,5694,84078,3562,5567,6233,5605,5707,10326,196883,5528,5718,2253,208,817,3809,3106,57761,2534,5693,23239,7450,9693,5582,1846,5290,5529,5719,2254,64096,100847012,3674,5781,11221,2244,207,25759,5720,8437,3558,5155,7414,818,2066,2475,941,29851,3164,54756,1027,8660,2065,5691,8074,27040,5156,2932,2255,2931,942,3643,5692,4893,122706,6710,114,10125,5710,143471,88,7157,23198,1844,7979,192669,2064,117145,6850,5519,3084,5527,5717,1147,115727,5708,5568,9861,53358,5581,2246,283455,5154,10048,3690,115,6708,3667,7010,5573,685,84335,5786,113,5908,3845,3716,5728,5518,54210,815,51332,10451,5153,5687,9542,8817,5894,55615,5245,567,801,7249,5037,1950,6709,1439,940,5696,57731,5536,5305,9436,5604,5623,5695,2252,109,814,8503,23112,8831,1385,5879,284,1843	UBA52,PSMB10,FGF20,PRKAR2B,KLRD1,FRS2,MAPK3,CALM2,PSMA3,MAPKAP1,CD300LB,FOXO1,DAB2IP,CASP9,PRKCD,MOV10,NRTN,CNKSR1,PSMD7,RBX1,PAQR3,TYROBP,RASAL3,PDE1C,NRG3,PRKACA,FGF3,FGG,PSMC6,PSMD5,KIT,GRIN2D,GAB1,LAMTOR3,SPTBN1,BRAF,NCAM1,IQGAP1,ARRB2,PIK3AP1,GRIN2C,GDNF,AKAP9,IL5,INS,SPRED3,NF1,DUSP5,PPP2CB,PSMC3,KLRC4-KLRK1,PTK2,RAP1A,MLST8,GRB2,GFRA1,MAP3K11,RASA2,JAK3,RASAL2,DUSP8,FGF4,CD300E,UBB,FGF17,PPP2CA,DUSP16,PHLPP2,MARK3,HLA-C,CSK,ADCY5,SRC,TRAT1,PSMD14,PIK3R1,CUL3,RET,CDKN1A,LCK,MDM2,APBB1IP,PSMB9,IL2RB,PIK3R2,NEFL,AGO2,PSMD8,PIP5K1A,CAMK2B,FOXO3,VAV2,GRIN2A,RASGRF1,GFRA3,PSME3,PSMF1,FGFR2,SIGLEC15,FRS3,EREG,ADCY6,GFRA2,PRKCA,UBC,PDGFRB,NRG4,YWHAB,RICTOR,WDR83,PSMA1,PSMD9,PPP2R5A,PIP5K1B,CALM3,SPRED2,FGF19,FGF5,DUSP7,IER3,PIP4K2B,RASA1,PPP2R5B,ITPR2,SOS1,GRAP2,PSMC2,FGFR3,FN1,AHCYL1,SPRED1,FGF2,SIGLEC14,PSMB2,TNRC6C,PSMA5,PLCG2,DLG4,SPTBN2,HLA-E,VAV1,RASGEF1A,ADCY2,PSMA4,JAK2,PLCG1,AKT3,MAPK1,PIK3CD,ITPR1,PDPK1,IL5RA,CD19,DUSP6,GRIN2B,CLEC5A,RASGRF2,SHC1,ITPR3,PSMC4,PIK3CB,FGFR4,RASA4,TNRC6A,GRK2,AGO1,ADCY1,BRAP,EGFR,HBEGF,FGF22,KL,AGO4,FGA,SIGLEC16,RPS6KB2,FGFR1,PSMC1,PRKAR1B,IL2RA,KITLG,HGF,PIP4K2C,FGF6,LAMTOR2,RASGRP3,PDE1A,CSF2,ARTN,PRKAR2A,MET,LCP2,ARRB1,HRAS,KLRK1,PEA15,PIP5K1C,PSMB6,KBTBD7,IL3,PRKACB,RPS27A,MAP2K2,PSMD1,SIRPB1,ADCY4,PPP2R5D,PSMD12,FGF8,AKT2,CAMK2D,KIR2DS4,HLA-B,TRIB3,FYN,PSMB5,PHLPP1,VWF,RAPGEF2,PRKCG,DUSP4,PIK3CA,PPP2R5E,PSMD13,FGF9,GFRA4,MIR5004,ITGA2B,PTPN11,DUSP10,FGB,AKT1,SHC2,PSME1,RASAL1,IL2,PDGFB,VCL,CAMK2G,ERBB4,MTOR,CD80,ICOS,NR4A1,IL17RD,CDKN1B,IRS2,ERBB3,PSMB3,FGF23,LAT,PDGFRA,GSK3B,FGF10,GSK3A,CD86,INSR,PSMB4,NRAS,PSMB11,SPTB,ADCY8,RASGRP1,PSMD4,PSMA8,ACTN2,TP53,PSME4,DUSP2,SEM1,AGO3,ERBB2,THEM4,SYK,PPP2R1B,NRG1,PPP2R5C,PSMD11,CHUK,RASGRP4,PSMD2,PRKACG,PSMD6,SHC3,PRKCE,FGF1,KSR2,PDGFA,RANBP9,ITGB3,ADCY9,SPTA1,IRS1,TEK,PRKAR1A,BTC,AKT1S1,PTPRA,ADCY7,RAP1B,KRAS,JAK1,PTEN,PPP2R1A,TREM1,CAMK2A,SPTBN5,VAV3,PDE1B,PSMA6,NRG2,FGF18,RAF1,PRR5,PHB1,B2M,CALM1,TSC2,PEBP1,EGF,SPTAN1,CSF2RB,CD28,PSMB8,SPTBN4,PPP5C,PIP4K2A,NCR2,MAP2K1,PSPN,PSMB7,FGF7,ADCY3,CAMK4,PIK3R3,TNRC6B,SYNGAP1,CREB1,RAC1,ANGPT1,DUSP1
R-HSA-199991	Membrane Trafficking	0.00686615087038889	-4.98115161063884	610	555	0.0614345804737658	9034	10285	8655,55291,10890,29979,5879,146909,7164,160,1523,10981,55014,9322,84643,5864,27147,4621,1950,57165,55667,7249,285643,157,1075,10254,27342,79961,84364,113220,11252,9648,11031,55083,51332,27183,1122,53632,27128,8906,57679,54732,8673,26088,79735,2153,57134,64746,7248,1212,10972,377,126432,9847,3949,26984,23243,22898,9117,6814,6456,23163,29993,3257,3796,51762,4218,5878,920,6857,85021,84251,84315,10282,6710,6455,23256,162,124602,5571,250,89953,22920,55763,10092,4626,10093,1213,10228,8675,29763,83452,10971,1856,2348,4625,9183,9276,149111,207,8766,9146,3834,5286,22878,2590,22930,1211,1294,64708,254263,9554,79571,287,115548,11004,26052,9585,201627,5870,51594,117177,6453,23557,10552,83874,60592,23396,375,51028,51272,81876,2801,1522,89781,29924,29127,84062,4622,9321,10466,1780,2803,79643,51014,8871,51552,11021,23216,381,8027,4641,9318,81846,339122,84516,90196,64786,2703,156,6643,8301,57589,11154,10175,50618,221960,7534,9609,2701,84342,10000,917,5874,6869,122553,4074,1080,5869,26286,27095,9712,1174,8773,8567,9525,10987,55330,2589,9493,51652,4124,808,10717,10802,22820,10133,201475,5868,1062,7251,25977,11037,9871,23258,23265,125111,10113,164,5563,51560,22848,8735,85439,56894,10652,9856,84316,7110,3312,8322,2580,3998,286,9698,388552,6810,9632,10112,60412,4619,10226,128637,55605,4646,9382,6714,9266,51226,53407,22905,54662,915,51112,11267,338,7314,2060,9265,273,2885,414918,1861,9829,27314,2706,58485,2512,3630,7474,5867,143425,23637,125058,11336,9950,5565,3092,51256,81930,130340,8615,152503,9570,8729,8546,2702,3267,23299,2017,1604,10097,163486,22931,50813,51510,2810,55357,9341,11316,149371,6764,91782,3832,22836,25839,23062,55770,950,382,84694,79720,57731,6709,801,51542,6811,55707,79748,23149,10640,51693,10109,9527,51128,9909,5861,6708,57644,4624,8867,79090,23208,23011,11337,64689,2709,8674,2665,1778,54874,10342,22989,259173,10260,26000,221458,7163,7082,10096,378,3835,9026,161,90019,551,64147,51138,63908,2804,1759,55048,10945,154,9892,4253,2799,2700,288,5049,10804,57533,11345,10920,100616314,57186,219770,10484,60560,2707,26153,57511,9267,6517,27333,26119,51422,54536,137492,208,10671,81631,54453,10960,8398,3833,60684,23046,80006,4012,6233,147700,5866,11070,51429,6396,408,92421,100313843,23303,122830,57369,23095,10618,7018,55614,127833,374,81567,6272,57148,5048,10244,10749,5321,3831,83696,9135,1777,128866,51164,1956,4121,11014,400,51143,112574,5537,6836,4036,966,5564,84958,10427,23431,26958,1453,163,22818,11196,7039,23433,10959,79058,27131,8907,2873,738,55850,55275,55738,163259,11311,6712,11258,27348,9685,8408,157807,11127,8533,7533,5873,134829,127534,4644,90411,1781,1173,8774,57706,7529,7316,2800,1783,1362,25782,2697,5898,22796,58513,7531,23682,1315,9610,10053,6457,83548,26130,3797,10905,8677,51534,5872,3799,10540,84313,10052,7532,55582,6844,2495,64837,56992,4905,662,4620,2890,23647,84079,867,185,5265,22872,1129,1601,79890,10094,26258,9882,89866,547,11015,409,3482,57465,6711,140735,91949,636,7037,7109,22879,23048,1785,8218,160518,1175,3798,79958,23423,375056,25978,29988,7879,60561,351,372,2844,1176,805,274,1639,8976,54734,4122,7311	DYNLL1,PPP6R3,RAB10,UBQLN1,RAC1,KIF18B,TPD52L1,AP2A1,CUX1,RAB32,STX17,TRIP10,KIF2B,RAB3A,DENND2A,MYH3,EGF,GJC2,DENND4C,TSC2,KIF4B,GRK3,CTSC,STAM2,RABGEF1,DENND2D,ARFGAP2,KIF12,PACSIN2,GCC2,RAB31,KIF26B,SPTBN5,VPS4A,CHML,PRKAG3,CYTH4,AP1G2,ALS2,TMED9,VAMP8,GGA1,TBC1D17,F5,MAN1C1,ACBD3,TSC1,CLTB,TMED10,ARF3,RINL,C2CD5,LDLR,SEC22A,ANKRD28,DENND3,SEC22C,STXBP3,SH3GL2,GGA3,PACSIN1,HPS1,KIF2A,RAB8B,RAB8A,RAB5C,CD4,SYT1,REPS1,SGIP1,MON1A,BET1,SPTB,SH3GL1,SCFD1,AP1B1,KIF19,PRKAG1,ALPP,KLC4,KIFAP3,EXOC1,ARPC5,MYH8,ARPC4,CLTC,STX6,STX16,PACSIN3,RAB33B,YWHAQ,DVL2,FOLR1,MYH7,ZW10,COPB2,CNIH3,AKT1,RAB11A,HGS,KIF25,PIK3C2A,TRAPPC8,GALNT2,RAB3GAP1,CLTA,COL7A1,COPS7B,CNIH2,SEC22B,GCC1,ANK2,FCHO2,KIF2C,DNM3,KIF20B,DENND6A,RAB6A,NBAS,RAB3IP,ITSN1,SNAPIN,ARPC1A,TBC1D10A,SCOC,PIP5K1C,ARF1,VPS36,BET1L,RAB1B,GOLGA2,CTSZ,HPS4,EPN1,RACGAP1,DTNBP1,MYH4,TRIP11,COG5,DYNC1I1,GOLGA4,CHMP6,TMED7,SYNJ2,RAB14,RAB35,TBC1D1,ARF5,STAM,MYO1C,COPS2,SBF2,RAB43,DCTN5,SYS1,TBC1D15,GJA8,GRK2,SNX2,PICALM,RIC1,AP4S1,CNIH1,ITSN2,CCZ1B,YWHAZ,RAB36,GJA4,COG8,AKT3,CD3G,RAB27B,TACR1,TRAPPC6B,M6PR,CFTR,RAB5B,ARFGAP3,TRAPPC3,USP6NL,AP1S1,SNAP23,MADD,VPS4B,COPS5,BLOC1S4,GALNT1,KIF23,CHMP3,MAN2A1,CALM3,AP4B1,SEC24A,COPG1,OPTN,RAB12,RAB5A,CENPE,TSG101,NECAP1,STON1,SEC24D,DENND5A,EXOC7,GJD3,PREB,AP1G1,PRKAA2,RAB6B,AAK1,MYH13,STON2,AGPAT3,YKT6,KIAA0319,NAA38,TMF1,HSPA8,FZD4,GAK,LMAN1,ANK1,PUM1,BLOC1S3,STX4,SEC24C,KIF20A,EXOC4,MYH1,PLIN3,TBC1D20,KIF21A,MYO6,COG1,SRC,CYTH2,COPZ2,STX18,EPN2,TBC1D13,CD3D,TRAPPC12,SNF8,APOB,UBB,EPS15,CYTH3,AMPH,GRB2,DENND6B,TOR1A,DNAJC6,RAB30,GJB2,TRAPPC1,FTL,INS,WNT5A,RAB4A,SYT9,RABGAP1,TBC1D16,EXOC3,GOLGA5,PRKAB2,HIP1,TBC1D7,KIF18A,AP1S3,USO1,SH3D19,GOSR2,GBF1,AP3B1,GJA5,AGFG1,BICD2,CTTN,CD55,ACTR2,DENND1B,RAB18,COPS7A,CHMP5,SFN,TBC1D2,VAMP3,COPE,EXOC8,DENND2B,CHMP7,KIF11,RHOBTB3,COG4,GGA2,EXOC2,SCARB2,ARF6,GJA10,VPS37B,SPTBN4,SPTAN1,CALM1,VPS54,STX5,NECAP2,LMAN1L,FCHO1,EXOC5,TRAPPC2L,ARPC2,GOSR1,SAR1B,DENND4B,RAB1A,SPTA1,MYH7B,MYH6,SYNJ1,TRAPPC6A,SYT11,RAB21,GABARAP,GORASP1,GJB5,VAMP4,GDI2,DYNC1H1,FNBP1L,TFG,MYH15,ALS2CL,DENND4A,TBC1D10B,KIF6,TPD52,TJP1,ACTR3,ARF4,KIF22,HIP1R,AP2A2,SYT8,AVP,KIF9,COPS4,NAPB,GOLGB1,DNM1,VPS37C,KDELR1,ADRB2,SNAP91,MIA2,GNS,GJA3,ANK3,PAFAH1B2,GJB6,TBC1D14,GABARAPL2,COPS8,MIR4750,RALGAPA2,GJD4,SEC23A,NAA35,GJB3,KIF26A,COG6,CYTH1,SLC2A4,GOLIM4,LDLRAP1,PRKAG2,EXOC6,VPS37A,AKT2,DCTN6,MAP1LC3B,RIN2,LMAN2,PLA2G6,KIFC1,TRAPPC11,KIF21B,TRAPPC13,LNPEP,RPS27A,KLC3,RAB3IL1,TMEM115,SNX9,SEC13,ARRB1,CHMP4C,MIR711,KIF13B,NAA30,GJD2,KIF1B,TGOLN2,TF,KIF16B,SYT2,AREG,TXNDC5,SORT1,RALGAPB,PAFAH1B1,RABEPK,KIF1C,PLA2G4A,KLC1,TRAPPC9,RABEP1,DNASE2,CHMP4B,DCTN4,EGFR,MAN1A1,KDELR2,ARL1,DYNC1LI1,SNX18,PPP6C,SURF4,LRP2,CD59,PRKAB1,SYTL1,SEC24B,AP4E1,COPG2,CSNK1D,AP2B1,COPZ1,SEC23IP,TGFA,RHOQ,TMED2,ASPSCR1,SNX5,AP1M1,GPS1,VPS51,USE1,VPS53,ARFGAP1,DENND2C,VPS45,SPTBN2,DCTN3,TOR1B,CLINT1,ULK1,CLVS1,KIF3A,COPS3,YWHAH,RAB27A,CLVS2,GJB4,MYO5A,MCFD2,DYNC1I2,AP2M1,NAPG,DENND1A,YWHAB,UBC,GOLGA1,DYNC1LI2,CPD,RAB3GAP2,GJA1,RALA,COG2,EPS15L1,YWHAE,RAB38,COPB1,RIN1,AP1M2,SH3GL3,COG3,GAPVD1,KIF3C,MAN1A2,STX10,VTA1,RAB13,KIF5B,DCTN2,VPS25,GJC1,YWHAG,KIF27,VAMP2,FTH1,KLC2,KIF15,NSF,BNIP1,MYH2,GRIA1,ARFIP2,ANKRD27,CBL,AGTR1,SERPINA1,SEC31A,CHRM2,DAB2,RIN3,ARPC3,BLOC1S6,TBC1D4,SEC16B,KIF1A,KDELR3,ARRB2,IGF2R,TBC1D24,SPTBN1,DYNLL2,COG7,BICD1,TFRC,TRAPPC10,MON1B,FNBP1,DNM2,CLTCL1,DENND5B,AP2S1,KIF5A,DENND1C,TMED3,MIA3,CHMP2B,SLC2A8,RAB7A,RINT1,APP,ARCN1,GPR21,AP3S1,CALM2,BIN1,DCTN1,WASL,RAB39A,MAN2A2,UBA52
R-HSA-983705	Signaling by the B Cell Receptor (BCR)	0.00699018578711922	-4.96324814410262	229	213	0.0235775957493912	9034	10285	3667,5154,84335,685,5519,1147,3084,5527,5717,2064,117145,6850,9861,2246,5708,5710,143471,10125,7979,192669,7157,23198,2255,2931,3643,942,5692,122706,4893,8503,5695,2252,1385,23112,27071,4790,640,940,5696,6500,933,5305,5687,8817,9542,55615,7249,1950,84876,6786,801,3845,5518,5728,5707,6233,2253,5718,5528,3265,23396,5694,4233,80228,6199,2260,100616453,5700,4254,9365,192670,27006,25780,2251,3082,79837,3164,2475,941,29851,2065,8074,5691,5156,2932,1027,8660,5720,207,5155,2066,5290,5719,5529,23239,2254,5781,208,8915,57761,5693,2534,23291,8396,8870,3709,5526,6654,9965,2250,5966,10768,2247,4792,5701,2261,5682,5525,5715,8395,145957,253260,808,8945,5970,5159,7316,10197,9491,2069,2263,5579,5777,26523,4690,1956,1839,6464,3710,27327,5704,5291,2264,5685,7409,5170,930,5335,5293,10000,5594,3708,5686,8454,57690,5690,5336,6885,973,118788,4067,5706,10718,2248,2549,5711,3815,4343,4794,2308,842,29760,5713,10818,5595,7220,7311,26281,5699,84433,79109,805,5684,5296,4793,868,2309,974,3551,27161,5714,8394,5295,10892,50852,6714,10213,4193,5698,1026,3932,8822,5515,867,7314,23035,5516,5702,3630,2249,6725,64223,2885	IRS1,PDGFA,AKT1S1,BTC,PPP2R1B,CHUK,NRG1,PPP2R5C,PSMD11,ERBB2,THEM4,SYK,PSMD6,FGF1,PSMD2,PSMD4,PSMA8,RASGRP1,SEM1,AGO3,TP53,PSME4,FGF10,GSK3A,INSR,CD86,PSMB4,PSMB11,NRAS,PIK3R3,PSMB7,FGF7,CREB1,TNRC6B,DAPP1,NFKB1,BLK,CD28,PSMB8,SKP1,CD22,PIP4K2A,PSMA6,FGF18,NRG2,PRR5,TSC2,EGF,ORAI1,STIM1,CALM1,KRAS,PPP2R1A,PTEN,PSMD1,RPS27A,FGF8,PSMD12,PPP2R5D,HRAS,PIP5K1C,PSMB6,MET,ORAI2,RPS6KB2,FGFR1,MIR4687,PSMC1,KITLG,KL,AGO4,FGF22,RASGRP3,FGF6,HGF,PIP4K2C,NR4A1,MTOR,CD80,ICOS,ERBB3,FGF23,PSMB3,PDGFRA,GSK3B,CDKN1B,IRS2,PSME1,AKT1,PDGFB,ERBB4,PIK3CA,PSMD13,PPP2R5E,PHLPP1,FGF9,PTPN11,AKT2,BCL10,TRIB3,PSMB5,FYN,FBXW11,PIP4K2B,IER3,ITPR2,PPP2R5B,SOS1,FGF19,FGF5,REL,AHCYL1,FGF2,NFKBIA,PSMC2,FGFR3,PSMA1,PPP2R5A,PSMD9,PIP5K1B,NRG4,RICTOR,CALM3,BTRC,RELA,PDGFRB,UBC,PSME3,PSMF1,EREG,FGFR2,PRKCB,PTPN6,AGO1,NCK1,EGFR,HBEGF,SHC1,ITPR3,TNRC6A,PSMC4,PIK3CB,FGFR4,PSMA4,VAV1,PDPK1,CD19,PLCG1,PIK3CD,AKT3,MAPK1,ITPR1,PSMA5,CUL1,TNRC6C,PSMB2,PLCG2,MAP3K7,CD79A,PIK3AP1,LYN,PSMC6,NRG3,FGF3,GAB1,PSMD5,KIT,MOV10,NFKBIE,FOXO1,CASP9,BLNK,PSMD7,FRS2,MAPK3,TRPC1,UBA52,FGF20,PSMB10,CARD11,MAPKAP1,CALM2,PSMA3,PIK3R2,NFKBIB,CBLB,FOXO3,CD79B,IKBKB,AGO2,PSMD8,PIP5K1A,PIK3R1,MALT1,TRAT1,SRC,PSMD14,MDM2,PSMB9,CDKN1A,LCK,FGF17,PPP2CA,CBL,UBB,PHLPP2,PPP2CB,PSMC3,INS,FGF4,SRMS,MLST8,GRB2
R-HSA-1168372	Downstream signaling events of B Cell Receptor (BCR)	0.00713821039850668	-4.94229317851407	197	184	0.0203675005534647	9034	10285	208,8915,2534,5693,57761,5290,5719,5529,23239,2254,5781,5720,207,5155,2066,3164,941,2475,29851,8074,5691,2065,2932,5156,1027,8660,2260,6199,4254,5700,27006,9365,192670,25780,2251,3082,79837,4233,3265,5694,23396,5707,6233,2253,5528,5718,3845,5518,5728,8817,9542,5687,55615,7249,1950,940,5696,6500,5305,8503,5695,2252,4790,23112,1385,2931,2255,5692,942,3643,4893,122706,143471,5710,10125,192669,7979,23198,7157,5519,3084,1147,5717,5527,2064,117145,9861,2246,5708,3667,5154,84335,685,5516,5702,3630,2249,2885,64223,5515,8822,7314,23035,10892,5295,50852,6714,10213,4193,5698,1026,3932,5296,4793,2309,5714,3551,27161,8394,10818,5595,7311,26281,5699,79109,84433,5684,4343,4794,842,2308,5713,5706,10718,2248,2549,5711,3815,6885,118788,5686,8454,5690,57690,5685,7409,5170,930,5594,5293,10000,27327,5704,2264,5291,5579,26523,1839,1956,9491,10197,2069,2263,5159,7316,5525,5715,5682,8395,145957,253260,5970,8945,23291,8396,8870,5526,9965,2250,5966,2247,5701,4792,2261	AKT2,BCL10,FYN,PSMB5,TRIB3,PIK3CA,PSMD13,PPP2R5E,PHLPP1,FGF9,PTPN11,PSME1,AKT1,PDGFB,ERBB4,NR4A1,CD80,MTOR,ICOS,FGF23,PSMB3,ERBB3,GSK3B,PDGFRA,CDKN1B,IRS2,FGFR1,RPS6KB2,KITLG,PSMC1,FGF22,KL,AGO4,RASGRP3,FGF6,HGF,PIP4K2C,MET,HRAS,PSMB6,PIP5K1C,PSMD1,RPS27A,FGF8,PPP2R5D,PSMD12,KRAS,PPP2R1A,PTEN,FGF18,NRG2,PSMA6,PRR5,TSC2,EGF,CD28,PSMB8,SKP1,PIP4K2A,PIK3R3,PSMB7,FGF7,NFKB1,TNRC6B,CREB1,GSK3A,FGF10,PSMB4,CD86,INSR,NRAS,PSMB11,PSMA8,PSMD4,RASGRP1,AGO3,SEM1,PSME4,TP53,PPP2R1B,NRG1,CHUK,PSMD11,PPP2R5C,ERBB2,THEM4,PSMD6,FGF1,PSMD2,IRS1,PDGFA,AKT1S1,BTC,PPP2CB,PSMC3,INS,FGF4,GRB2,MLST8,PPP2CA,FGF17,UBB,PHLPP2,MALT1,PIK3R1,TRAT1,SRC,PSMD14,MDM2,PSMB9,CDKN1A,LCK,PIK3R2,NFKBIB,FOXO3,PSMD8,IKBKB,AGO2,PIP5K1A,FRS2,MAPK3,UBA52,FGF20,PSMB10,MAPKAP1,CARD11,PSMA3,MOV10,NFKBIE,CASP9,FOXO1,PSMD7,PSMC6,NRG3,FGF3,GAB1,PSMD5,KIT,MAP3K7,PIK3AP1,PSMA5,CUL1,PSMB2,TNRC6C,PSMA4,VAV1,PDPK1,CD19,MAPK1,PIK3CD,AKT3,TNRC6A,PSMC4,FGFR4,PIK3CB,PRKCB,AGO1,HBEGF,EGFR,PSMF1,PSME3,EREG,FGFR2,PDGFRB,UBC,PPP2R5A,PSMD9,PSMA1,PIP5K1B,NRG4,RICTOR,RELA,BTRC,FBXW11,PIP4K2B,IER3,PPP2R5B,FGF19,FGF5,REL,FGF2,PSMC2,NFKBIA,FGFR3
R-HSA-4420097	VEGFA-VEGFR2 Pathway	0.00727777241294102	-4.92293045083056	330	304	0.033650653088333	9034	10285	5692,2255,122706,4893,6710,9047,5603,10125,5710,143471,653361,88,23198,7979,1844,117145,2064,857,3685,3084,5527,5717,5519,5708,115727,2246,5568,2185,9861,53358,3690,6708,283455,10048,5154,3667,685,10787,7010,1793,5786,3716,5908,3845,3320,51332,815,7867,5518,10451,3071,5894,55615,5687,9542,8817,801,5245,1950,6709,63916,5037,5696,57731,1439,1495,5536,5623,5604,2252,5695,284,8831,5879,1843,27006,9365,2243,5700,4254,3559,2260,9475,3082,3791,25780,28956,2251,9048,1437,4233,8440,4689,408,3265,8682,84078,5694,7422,3562,5567,5058,5605,6233,5707,5590,5528,5718,2253,1398,208,817,10006,57761,2534,5693,7450,9693,1846,5529,5719,5290,2254,64096,3674,100847012,207,25759,11221,2244,5720,5062,3558,8437,7414,2066,818,5155,2475,54756,4688,8660,5156,2065,5691,27040,8074,2903,10810,7410,2676,10197,9491,5923,8877,2263,998,10817,2069,55845,2675,5578,4846,7316,5159,253260,84292,145957,7529,5682,5525,1003,5715,808,200734,1849,2250,9965,5526,3709,6654,5921,6461,2261,3728,5701,10768,161742,2247,2335,5690,9261,6300,5686,6712,1742,7409,5685,3717,221002,5594,10000,3708,5335,1848,5170,3568,2904,10152,3710,6464,5924,5291,2264,10156,5704,9564,8936,8315,5579,1956,1839,4690,26281,5600,5699,1535,1500,7311,5595,10818,3315,5684,805,10163,79109,5580,10458,1499,153090,4902,9978,152559,10256,5713,64926,2248,5566,10718,5706,2266,3815,5711,2906,8649,6711,8826,673,4684,409,2905,10142,2668,1847,4763,3567,399473,23191,5702,5516,4296,5922,3718,5747,5906,2885,2674,64223,2249,1850,9462,387,7314,8822,5515,5829,80824,1445,4140,10213,6714,1432,5295,26999,8452,5979,54518,5698,3560,4747,9844,5296,5714,816	PSMB4,FGF10,PSMB11,NRAS,SPTB,SH2D2A,MAPK13,RASGRP1,PSMD4,PSMA8,NCF1,ACTN2,PSME4,SEM1,DUSP2,THEM4,ERBB2,CAV1,ITGAV,NRG1,PPP2R5C,PSMD11,PPP2R1B,PSMD2,RASGRP4,FGF1,PRKACG,PTK2B,PSMD6,SHC3,ITGB3,SPTA1,KSR2,RANBP9,PDGFA,IRS1,BTC,NCKAP1,TEK,DOCK1,PTPRA,JAK1,RAP1B,KRAS,HSP90AA1,SPTBN5,CAMK2A,MAPKAPK3,PPP2R1A,VAV3,NCKAP1L,RAF1,PRR5,PSMA6,NRG2,FGF18,CALM1,PHB1,EGF,SPTAN1,ELMO2,PEBP1,PSMB8,SPTBN4,CSF2RB,CTNNA1,PPP5C,PSPN,MAP2K1,FGF7,PSMB7,ANGPT1,SYNGAP1,RAC1,DUSP1,FGF22,KL,FGA,PSMC1,KITLG,IL2RA,FGFR1,ROCK2,HGF,KDR,RASGRP3,LAMTOR2,FGF6,ARTN,CSF2,MET,NCK2,NCF4,ARRB1,HRAS,PEA15,KBTBD7,PSMB6,VEGFA,IL3,PRKACB,PAK1,MAP2K2,RPS27A,PSMD1,PRKCZ,PPP2R5D,PSMD12,FGF8,CRK,AKT2,CAMK2D,ABI1,TRIB3,FYN,PSMB5,VWF,RAPGEF2,DUSP4,PPP2R5E,PSMD13,PIK3CA,FGF9,GFRA4,ITGA2B,MIR5004,AKT1,SHC2,DUSP10,FGB,PSME1,PAK2,IL2,RASAL1,VCL,ERBB4,CAMK2G,PDGFB,MTOR,IL17RD,NCF2,IRS2,PDGFRA,ERBB3,PSMB3,LAT,FGF23,GRIN2A,WASF3,VAV2,GFRA3,PSME3,PSMF1,RASGRF1,SPHK1,FGFR2,CDC42,FRS3,EREG,BRK1,GFRA2,PRKCA,NOS3,UBC,PDGFRB,RICTOR,WDR83,NRG4,YWHAB,PSMA1,PPP2R5A,CDH5,PSMD9,CALM3,SPRED2,DUSP7,FGF5,FGF19,PPP2R5B,ITPR2,SOS1,RASA1,SHB,FGFR3,JUP,PSMC2,AHCYL1,SPRED1,FGF2,FN1,PSMB2,MAPKAPK2,MAPK12,PSMA5,SPTBN2,DLG4,VAV1,PSMA4,JAK2,RASGEF1A,MAPK1,AKT3,ITPR1,PLCG1,DUSP6,PDPK1,IL5RA,GRIN2B,ABI2,ITPR3,SHC1,RASGRF2,PIK3CB,FGFR4,RASA4,PSMC4,BCAR1,WASF1,BRAP,PRKCB,EGFR,HBEGF,NCK1,FGF20,MAPK11,PSMB10,CYBA,CTNND1,UBA52,MAPK3,FRS2,HSPB1,PSMA3,CALM2,WASF2,MAPKAP1,PRKCD,BAIAP2,CTNNB1,DAB2IP,NRTN,RBX1,PAQR3,CNKSR1,PSMD7,RASAL3,FGF3,PRKACA,NRG3,PSMC6,FGG,KIT,PSMD5,GRIN2D,LAMTOR3,SPTBN1,IQGAP1,BRAF,NCAM1,ARRB2,GRIN2C,AKAP9,GDNF,DUSP5,NF1,IL5,SPRED3,CYFIP1,PSMC3,PPP2CB,MAP3K11,RASA2,JAK3,PTK2,RAP1A,GRB2,GFRA1,MLST8,FGF4,DUSP8,RASAL2,RHOA,UBB,FGF17,PPP2CA,PXN,DUSP16,CSK,MARK3,PSMD14,SRC,MAPK14,PIK3R1,CYFIP2,CUL3,RET,APBB1IP,PSMB9,IL2RB,NEFL,ELMO1,PIK3R2,PSMD8,CAMK2B
R-HSA-112316	Neuronal System	0.00759874104506587	-4.87977269737667	349	321	0.0355324330307726	9034	10285	2036,10550,8973,808,2915,217,3785,2770,1145,1173,8541,2035,3786,3767,2901,2787,27012,3790,1146,3741,3751,22871,6237,9463,2903,3760,3775,5923,5792,3743,5578,8497,2899,100126325,112,6540,84254,3776,1135,27133,140679,2319,23426,26045,2792,2557,9196,2904,5924,6196,57596,3744,1136,1312,320,2898,9369,107,5579,55799,55970,6195,3772,10611,6506,1742,10242,10021,341359,6511,3754,5594,2561,163,59345,5170,6505,347730,3782,2550,57669,108,27345,1142,3746,1141,89822,2788,169522,2906,2793,3768,3781,5789,100616414,5566,2911,2562,783,8825,3773,3745,143425,6512,10142,2905,1134,673,805,9495,43,6580,27094,3755,1143,10815,1175,2791,23416,57555,6539,2559,26037,170850,3756,784,8499,321,4193,2897,58512,80059,111,4646,3736,4905,1144,54207,3312,8500,55327,816,3784,2558,6844,10052,6538,90134,3752,22941,9424,4747,3742,83988,10368,6854,2566,27163,81539,2890,6833,10211,50944,2570,51764,5331,785,93107,6616,9378,5568,3787,2790,3766,2786,2569,3748,2037,5802,27165,3765,9568,115,9546,56666,55584,3770,9455,81033,1740,114,11094,3739,28988,3777,781,10089,3758,88,22839,9456,406974,26251,6532,3780,50801,6857,6571,24145,8224,9256,3738,1137,5330,80852,160,2571,18,2555,5864,2891,348980,1385,10060,22999,54331,84694,109,2744,79414,3759,814,131096,3749,27092,815,91683,23136,3762,113,2782,56659,9379,10681,773,801,6507,27020,2893,5894,9229,777,2773,3265,9254,3747,10369,196883,83795,3761,7915,2554,3788,200959,6812,5567,23236,10313,59283,26290,2783,3763,2900,78999,1739,3757,8514,3778,1139,2771,610,2572,127833,9066,23415,57369,9312,10497,2784,3764,818,2752,6531,2560,54407,1103,57030,94235,60482,161,590,9132,3737,1138,3779,346562,817,6582,2774,56479,6529,9228,57497,80331,51305,338567,5582,9454,2567,347731,7881	EPB41L1,ARL6IP5,CHRNA6,CALM3,GRM5,ALDH2,KCNQ2,GNAI1,CHRNE,AP2M1,PPFIA3,EPB41,KCNQ3,KCNJ11,GRIK5,GNG5,KCNV1,KCNS3,CHRNG,KCNA5,KCND2,NLGN1,RRAS,PICK1,GRIN2A,KCNJ3,KCNK1,RASGRF1,PTPRF,KCNA7,PRKCA,PPFIA4,GRIK3,MIR935,ADCY6,SLC6A13,CAMKK1,KCNK2,CHRNA2,KCNH5,SLC32A1,FLOT2,GRIP1,LRRTM2,GNGT1,GABRA4,KCNAB3,GRIN2B,RASGRF2,RPS6KA2,BEGAIN,KCNA10,CHRNA3,COMT,APBA1,GRIK2,NRXN3,ADCY1,PRKCB,CACNA2D3,GNG12,RPS6KA1,KCNJ15,PDLIM5,SLC1A2,DLG4,KCNMB2,HCN4,SYT10,SLC1A6,KCNF1,MAPK1,GABRB2,AP2B1,GNB4,PDPK1,SLC1A1,LRRTM1,KCNN3,GABBR1,EPB41L5,ADCY2,KCNMB4,CHRNB3,KCNC1,CHRNB2,KCNK17,GNG7,KCNV2,GRIN2D,GNGT2,KCNJ12,KCNN2,PTPRD,MIR4761,PRKACA,GRM1,GABRB3,CACNB2,LIN7A,KCNJ16,KCNB1,SYT9,SLC1A7,AKAP9,GRIN2C,CHRNA1,BRAF,CALM2,AKAP5,ACHE,SLC22A1,KCNMB3,KCNG1,CHRNB4,CPLX1,AP2S1,GNG11,KCNH3,NLGN2,SLC6A12,GABRA6,SIPA1L1,KCNG3,KCNH1,CACNB3,PPFIA2,APBA2,MDM2,GRIK1,DLGAP3,LRRTM4,ADCY5,MYO6,KCNA1,NSF,CHRND,KCNK10,HSPA8,PPFIA1,LIN7C,CAMK2B,KCNQ1,GABRA5,VAMP2,GJC1,SLC6A11,KCNH7,KCND3,SHANK2,KCNK6,NEFL,KCNA6,NCALD,CACNG3,SYN2,GABRG2,NAAA,SLC38A1,GRIA1,ABCC8,FLOT1,SHANK1,GABRR2,GNG13,PLCB3,CACNB4,KCNG4,SNAP25,NRXN1,PRKACG,KCNS1,GNG10,KCNJ10,GNG4,GABRR1,KCNC3,EPB41L2,PTPRS,GLS2,KCNJ9,GABBR2,ADCY9,APBA3,PANX2,CHRNA9,KCNJ14,HOMER2,KCNH6,DLG2,ADCY8,CACFD1,KCNA4,DBNL,KCNK3,CACNA2D1,KCNK7,KCNJ1,ACTN2,DLGAP4,HOMER1,MIR197,KCNG2,SLC6A4,KCNN1,KCNK4,SYT1,SLC18A2,PANX1,SYN3,TSPOAP1,KCNA3,CHRNA4,PLCB2,GRIP2,AP2A1,GAD1,ABAT,GABRA2,RAB3A,GRIA2,HCN1,CREB1,ABCC9,RIMS1,GNG2,GJA10,ADCY3,GLS,LRFN3,KCNJ2,CAMK4,KCNH8,KCNC4,CACNG4,CAMK2A,SYT12,EPB41L3,KCNJ5,ADCY7,GNB1,KCNK13,NRXN2,GNB5,CACNA1A,CALM1,SLC1A3,NPTN,GRIA4,RAF1,DLGAP1,CACNA1E,GNAI3,HRAS,CACNA2D2,KCNC2,CACNG2,ADCY4,KCNK16,KCNJ4,ALDH5A1,GABRA1,KCNS2,GABRR3,STXBP1,PRKACB,PLCB1,RTN3,CACNG8,GALNT8,GNB2,KCNJ6,GRIK4,LRFN4,DLG1,KCNH2,KCNAB2,KCNMA1,CHRNA7,GNAI2,HCN2,GAD2,SYT2,SYT7,KCNH4,GJD2,KCNB2,UNC13B,GNB3,KCNJ8,CAMK2G,GLUL,SLC6A3,GABRB1,SLC38A2,CHAT,SLC17A7,GNG8,SLC5A7,AP2A2,BCHE,KCNQ4,KCNA2,CHRNA5,KCNMB1,GNAT3,CAMK2D,SLC22A2,GNAL,KCNQ5,SLC6A1,DLGAP2,LRFN2,DNAJC5,KCNK9,KCNK18,PRKCG,HOMER3,GABRG3,LRRTM3,KCNAB1
R-HSA-156580	Phase II conjugation	0.00792139101167814	-4.83818845578979	106	101	0.0111799867168475	9034	10285	54579,1544,2938,2944,79799,574537,6820,389396,9061,116285,2687,494143,6819,2949,4144,124975,167127,10327,9446,219970,10249,2954,2686,57412,55748,10941,54490,55347,2098,348158,4143,91227,79017,54657,221357,2948,373156,4257,7360,4837,10,2953,2729,7358,6822,2941,341392,4552,54576,51504,79094,1312,2939,7366,54578,54600,51000,7365,191,6799,1836,4548,27233,27284,119391,23169,2952,2937,25830,2678,9060,7364,29104,27306,100616124,133688,54659,100616414,4259,9,7363,54658,2730,2946,10720,10380,4258,10861,347734,6817,92292,2947,2950,123876,6783,2940,2679,84836,27430,54577,7172	UGT1A5,CYP1A2,GSTA1,GSTM1,UGT2A3,UGT2A2,SULT2B1,GLYATL3,PAPSS1,ACSM1,GGT5,CHAC2,SULT1C2,GSTM5,MAT2A,GGT6,UGT3A2,AKR1A1,GSTO1,GLYATL2,GLYAT,GSTZ1,GGT7,AS3MT,CNDP2,UGT2A1,UGT2B28,ABHD10,ESD,ACSM2B,MAT1A,GGTLC2,GGCT,UGT1A4,GSTA5,GSTM4,GSTK1,MGST1,UGP2,NNMT,NAT2,GSTT2,GCLC,UGDH,SULT2A1,GSTA4,ACSM4,MTRR,UGT1A8,TRMT112,CHAC1,COMT,GSTA2,UGT2B15,UGT1A6,UGT1A9,SLC35B3,UGT2B10,AHCY,SULT1A2,SLC26A2,MTR,SULT1C4,SULT1B1,GSTO2,SLC35D1,GSTT1,GSS,SULT4A1,GGT1,PAPSS2,UGT2B7,N6AMT1,HPGDS,MIR4647,UGT3A1,UGT1A3,MIR4761,MGST3,NAT1,UGT2B4,UGT1A1,GCLM,GSTM2,UGT2B11,BPNT1,MGST2,SLC26A1,SLC35B2,SULT1A1,GLYATL1,GSTM3,GSTP1,ACSM2A,SULT1E1,GSTA3,GGT3P,ABHD14B,MAT2B,UGT1A7,TPMT
R-HSA-194138	Signaling by VEGF	0.00805561782366243	-4.82138556465365	338	311	0.0344255036528669	9034	10285	5710,653361,143471,10125,7979,1844,7424,88,23198,5692,2255,6710,9047,5603,4893,122706,3667,3690,6708,283455,5154,10048,1793,8828,685,10787,7010,3685,3084,5717,5527,5519,117145,2064,857,2246,5568,2185,9861,53358,5708,115727,5894,8829,55615,5687,8817,9542,3071,1950,6709,63916,5037,801,5245,3716,5908,3845,5786,10451,815,51332,3320,7867,5518,2252,5695,1843,7423,284,8831,5879,5536,5696,57731,1495,1439,5623,5604,4233,8440,9048,1437,408,4689,5700,4254,3559,2260,27006,9365,2243,25780,28956,2251,9475,3082,3791,5707,5590,7422,3562,5567,5058,2324,5605,6233,2253,5528,5718,3265,84078,5694,8682,5719,5529,5290,9693,7450,1846,64096,2254,3674,100847012,5228,208,1398,57761,2534,5693,10006,817,54756,4688,2475,5156,2065,5691,8074,27040,8660,5720,207,25759,2321,11221,2244,7414,2066,818,5155,3558,5062,8437,55845,2675,7316,5159,5578,4846,2676,10197,9491,8877,5923,10810,2903,7410,10817,2069,2263,998,3709,5526,6654,6461,5921,2250,1849,9965,10768,161742,2247,2335,2261,3728,5701,5682,1003,5525,5715,84292,253260,7529,145957,808,200734,5685,3717,221002,7409,1848,5170,3568,5594,10000,3708,5335,5686,5690,9261,6300,6712,1742,8936,8315,5579,9564,1956,1839,4690,3710,6464,5924,2904,10152,2264,5291,10156,5704,4902,10458,5580,1499,153090,64926,9978,152559,10256,5713,5595,10818,5699,5600,26281,1500,1535,7311,10163,79109,3315,5684,805,8826,673,4684,8649,6711,2905,10142,2668,409,5706,2266,2248,5566,10718,2906,3815,5711,5515,8822,387,7314,1445,4140,5829,80824,5702,23191,5516,4763,1847,3567,399473,1850,2249,9462,4296,5922,3718,5747,2674,5906,64223,2885,4747,9844,5296,3560,816,5714,5295,26999,10213,1432,6714,54518,5698,8452,5979	PSMD4,NCF1,PSMA8,RASGRP1,SEM1,DUSP2,VEGFC,ACTN2,PSME4,PSMB4,FGF10,SPTB,SH2D2A,MAPK13,NRAS,PSMB11,IRS1,ITGB3,SPTA1,KSR2,PDGFA,RANBP9,DOCK1,NRP2,BTC,NCKAP1,TEK,ITGAV,NRG1,PSMD11,PPP2R5C,PPP2R1B,THEM4,ERBB2,CAV1,FGF1,PRKACG,PTK2B,PSMD6,SHC3,PSMD2,RASGRP4,RAF1,NRP1,PRR5,PSMA6,FGF18,NRG2,NCKAP1L,EGF,SPTAN1,ELMO2,PEBP1,CALM1,PHB1,JAK1,RAP1B,KRAS,PTPRA,VAV3,CAMK2A,SPTBN5,HSP90AA1,MAPKAPK3,PPP2R1A,FGF7,PSMB7,DUSP1,VEGFB,ANGPT1,SYNGAP1,RAC1,PPP5C,PSMB8,SPTBN4,CTNNA1,CSF2RB,PSPN,MAP2K1,MET,NCK2,ARTN,CSF2,ARRB1,NCF4,PSMC1,KITLG,IL2RA,FGFR1,FGF22,KL,FGA,RASGRP3,LAMTOR2,FGF6,ROCK2,HGF,KDR,PSMD1,PRKCZ,VEGFA,IL3,PRKACB,PAK1,FLT4,MAP2K2,RPS27A,FGF8,PPP2R5D,PSMD12,HRAS,KBTBD7,PSMB6,PEA15,PSMD13,PPP2R5E,PIK3CA,RAPGEF2,VWF,DUSP4,GFRA4,FGF9,ITGA2B,MIR5004,PGF,AKT2,CRK,TRIB3,FYN,PSMB5,ABI1,CAMK2D,IL17RD,NCF2,MTOR,PDGFRA,ERBB3,PSMB3,FGF23,LAT,IRS2,PSME1,AKT1,SHC2,FLT1,DUSP10,FGB,VCL,ERBB4,CAMK2G,PDGFB,IL2,PAK2,RASAL1,BRK1,GFRA2,UBC,PDGFRB,PRKCA,NOS3,GFRA3,PSME3,PSMF1,SPHK1,RASGRF1,WASF3,GRIN2A,VAV2,FRS3,EREG,FGFR2,CDC42,ITPR2,PPP2R5B,SOS1,SHB,RASA1,FGF5,DUSP7,FGF19,AHCYL1,SPRED1,FGF2,FN1,FGFR3,JUP,PSMC2,PSMA1,CDH5,PPP2R5A,PSMD9,WDR83,RICTOR,YWHAB,NRG4,CALM3,SPRED2,PSMA4,JAK2,RASGEF1A,VAV1,DUSP6,PDPK1,IL5RA,MAPK1,AKT3,ITPR1,PLCG1,PSMA5,PSMB2,MAPKAPK2,MAPK12,SPTBN2,DLG4,WASF1,BRAP,PRKCB,BCAR1,EGFR,HBEGF,NCK1,ITPR3,SHC1,RASGRF2,GRIN2B,ABI2,FGFR4,PIK3CB,RASA4,PSMC4,NRTN,BAIAP2,PRKCD,CTNNB1,DAB2IP,RASAL3,RBX1,PAQR3,CNKSR1,PSMD7,MAPK3,FRS2,PSMB10,MAPK11,FGF20,CTNND1,CYBA,UBA52,WASF2,MAPKAP1,HSPB1,PSMA3,CALM2,IQGAP1,BRAF,NCAM1,LAMTOR3,SPTBN1,GRIN2C,AKAP9,GDNF,ARRB2,PSMC6,FGG,FGF3,PRKACA,NRG3,GRIN2D,KIT,PSMD5,PPP2CA,FGF17,RHOA,UBB,CSK,MARK3,PXN,DUSP16,PSMC3,CYFIP1,PPP2CB,NF1,DUSP5,IL5,SPRED3,DUSP8,FGF4,RASAL2,MAP3K11,RASA2,JAK3,PTK2,GFRA1,RAP1A,MLST8,GRB2,NEFL,ELMO1,PIK3R2,IL2RB,CAMK2B,PSMD8,PIK3R1,CYFIP2,PSMD14,MAPK14,SRC,APBB1IP,PSMB9,CUL3,RET
R-HSA-74751	Insulin receptor signalling cascade	0.00858921190624629	-4.75724829268422	297	274	0.0303298649546159	9034	10285	1839,1956,55437,8315,5564,5704,10156,5291,2264,6464,5924,2904,5170,3568,1848,5594,221002,3717,5685,1742,6712,5494,5686,1981,5690,2335,161742,2247,5701,2261,5921,6654,5526,9965,1849,2250,5289,200734,808,5715,5525,5682,145957,7529,84292,7316,5159,2675,2069,5563,10817,2263,5923,64121,9491,2676,10197,2903,816,5714,5296,4747,3560,5698,1975,54518,5979,8452,5295,6714,29904,10213,5140,4140,1445,92335,55004,80824,5515,8822,7314,9462,2249,1850,2885,64223,2674,5906,5747,3718,5922,4296,5516,5702,399473,3630,3567,5562,1847,4763,2668,10142,2905,409,4684,673,8826,6711,6794,8649,5565,2906,2549,5711,6194,3815,2266,5706,81617,10718,2248,64926,10670,5713,10256,152559,9978,4902,153090,805,5684,6009,10818,5595,7311,5699,26281,1843,8831,284,1978,5695,2252,10542,5604,5623,5536,1439,57731,5696,5037,7249,6709,1950,5245,801,9542,8817,5687,5894,53632,5518,51332,815,3845,5908,3716,5786,84335,7010,685,3667,10048,5154,283455,7248,6708,3690,53358,9861,57521,2246,115727,5708,5519,5527,5717,3084,30849,2064,117145,1844,7979,23198,88,143471,5710,10125,58528,6710,4893,122706,5571,2255,5692,3643,8074,27040,5691,2065,5156,8660,54756,2475,389541,1977,5155,2066,818,7414,8437,6198,3558,5720,11221,2244,25759,51719,207,3674,100847012,64096,2254,5781,5290,5529,5719,1846,7450,9693,2534,5693,57761,51422,817,2887,208,2253,5528,5718,5707,6233,5605,3562,5694,84078,8682,3265,408,54106,4233,1437,9048,2251,28956,25780,3082,2260,4254,3559,5700,2243,27006,9365	HBEGF,EGFR,STRADB,BRAP,PRKAB1,PSMC4,RASA4,PIK3CB,FGFR4,SHC1,RASGRF2,GRIN2B,PDPK1,IL5RA,DUSP6,MAPK1,RASGEF1A,JAK2,PSMA4,DLG4,SPTBN2,PPM1A,PSMA5,EIF4G1,PSMB2,FN1,SPRED1,FGF2,PSMC2,FGFR3,RASA1,SOS1,PPP2R5B,FGF19,DUSP7,FGF5,PIK3C3,SPRED2,CALM3,PSMD9,PPP2R5A,PSMA1,NRG4,YWHAB,WDR83,UBC,PDGFRB,GFRA2,EREG,PRKAA2,FRS3,FGFR2,RASGRF1,RRAGC,PSMF1,GFRA3,PSME3,GRIN2A,CAMK2B,PSMD8,PIK3R2,NEFL,IL2RB,PSMB9,EIF4B,APBB1IP,RET,CUL3,PIK3R1,SRC,EEF2K,PSMD14,PDE3B,MARK3,CSK,STRADA,LAMTOR1,DUSP16,PPP2CA,FGF17,UBB,RASAL2,FGF4,DUSP8,GRB2,MLST8,GFRA1,RAP1A,PTK2,JAK3,RASA2,MAP3K11,PPP2CB,PSMC3,SPRED3,INS,IL5,PRKAA1,DUSP5,NF1,GDNF,AKAP9,GRIN2C,ARRB2,NCAM1,BRAF,IQGAP1,SPTBN1,STK11,LAMTOR3,PRKAB2,GRIN2D,GAB1,PSMD5,RPS6,KIT,FGG,PSMC6,CAB39L,NRG3,FGF3,RASAL3,RRAGA,PSMD7,CNKSR1,PAQR3,RBX1,NRTN,DAB2IP,CALM2,PSMA3,RHEB,FRS2,MAPK3,UBA52,PSMB10,FGF20,DUSP1,SYNGAP1,ANGPT1,EIF4EBP1,PSMB7,FGF7,LAMTOR5,MAP2K1,PSPN,PPP5C,CSF2RB,SPTBN4,PSMB8,PEBP1,TSC2,SPTAN1,EGF,PHB1,CALM1,NRG2,FGF18,PSMA6,RAF1,PRKAG3,PPP2R1A,SPTBN5,CAMK2A,KRAS,RAP1B,JAK1,PTPRA,AKT1S1,TEK,BTC,IRS1,RANBP9,PDGFA,KSR2,TSC1,SPTA1,ITGB3,SHC3,PSMD6,RPTOR,FGF1,RASGRP4,PSMD2,PPP2R1B,PPP2R5C,PSMD11,NRG1,PIK3R4,ERBB2,THEM4,DUSP2,SEM1,PSME4,ACTN2,PSMA8,PSMD4,RASGRP1,RRAGD,SPTB,NRAS,PSMB11,PRKAG1,FGF10,PSMB4,INSR,FGF23,LAT,PSMB3,ERBB3,PDGFRA,IRS2,IL17RD,MTOR,LAMTOR4,EIF4E,PDGFB,ERBB4,CAMK2G,VCL,RASAL1,RPS6KB1,IL2,PSME1,DUSP10,FGB,SHC2,CAB39,AKT1,ITGA2B,MIR5004,GFRA4,FGF9,PTPN11,PIK3CA,PPP2R5E,PSMD13,DUSP4,VWF,RAPGEF2,FYN,PSMB5,TRIB3,PRKAG2,CAMK2D,GRB10,AKT2,FGF8,PPP2R5D,PSMD12,PSMD1,RPS27A,MAP2K2,IL3,PSMB6,KBTBD7,PEA15,HRAS,ARRB1,TLR9,MET,CSF2,ARTN,FGF6,LAMTOR2,RASGRP3,HGF,FGFR1,KITLG,IL2RA,PSMC1,FGA,FGF22,KL
R-HSA-6806003	Regulation of TP53 Expression and Degradation	0.00930326824486645	-4.67738951637875	36	36	0.00398494576046048	9034	10285	5519,8900,5527,7874,6446,80196,207,253260,4193,6233,2475,890,11200,208,5516,1616,7311,9099,472,983,4194,79109,64223,1029,5518,1017,55615,5515,7314,5170,117584,7316,639,7157,900,10000	PPP2R1B,CCNA1,PPP2R5C,USP7,SGK1,RNF34,AKT1,RICTOR,MDM2,RPS27A,MTOR,CCNA2,CHEK2,AKT2,PPP2CB,DAXX,UBA52,USP2,ATM,CDK1,MDM4,MAPKAP1,MLST8,CDKN2A,PPP2R1A,CDK2,PRR5,PPP2CA,UBB,PDPK1,RFFL,UBC,PRDM1,TP53,CCNG1,AKT3
R-HSA-167021	PLC-gamma1 signalling	0.00930326824486645	-4.67738951637875	36	36	0.00398494576046048	9034	10285	5153,112,5582,5580,5576,108,5335,5578,3708,801,5137,113,5577,5575,4803,805,5136,114,5567,109,107,115,814,3709,1385,5573,196883,10768,5566,111,3710,4914,156,5581,808,5568	PDE1B,ADCY6,PRKCG,PRKCD,PRKAR2A,ADCY2,PLCG1,PRKCA,ITPR1,CALM1,PDE1C,ADCY7,PRKAR2B,PRKAR1B,NGF,CALM2,PDE1A,ADCY8,PRKACB,ADCY3,ADCY1,ADCY9,CAMK4,ITPR2,CREB1,PRKAR1A,ADCY4,AHCYL1,PRKACA,ADCY5,ITPR3,NTRK1,GRK2,PRKCE,CALM3,PRKACG
R-HSA-212718	EGFR interacts with phospholipase C-gamma	0.00930326824486645	-4.67738951637875	36	36	0.00398494576046048	9034	10285	5136,114,805,5575,5577,113,1950,5137,801,3708,5335,5578,5576,108,112,5582,5580,5153,5581,156,5568,808,3710,5566,111,1956,10768,5573,196883,1385,814,3709,107,109,115,5567	PDE1A,ADCY8,CALM2,PRKAR1B,PRKAR2B,ADCY7,EGF,PDE1C,CALM1,ITPR1,PLCG1,PRKCA,PRKAR2A,ADCY2,ADCY6,PRKCG,PRKCD,PDE1B,PRKCE,GRK2,PRKACG,CALM3,ITPR3,PRKACA,ADCY5,EGFR,AHCYL1,PRKAR1A,ADCY4,CREB1,CAMK4,ITPR2,ADCY1,ADCY3,ADCY9,PRKACB
R-HSA-168256	Immune System	0.00939416433285024	-4.66766659814624	2101	1877	0.207770644232898	9034	10285	140735,60,55740,3815,5711,10437,7128,6993,9961,329,8826,3146,7879,351,5684,3663,4215,5897,2033,71,6367,8976,84513,5699,1436,1535,2204,57161,152559,100293534,1175,245928,23412,1499,4360,842,5698,4193,90423,50856,1026,26999,2635,3443,23165,5592,7456,122769,5008,2950,9462,5788,116379,8741,3434,5747,9817,4763,84265,26272,53917,867,5608,30835,1781,388646,2690,1173,5525,7529,2247,10768,3728,27178,5873,9447,3665,1650,10392,245940,284266,5923,138050,55008,5159,10666,140739,2675,11240,55845,112,6478,4055,391,27327,10156,3326,115004,5704,26224,83737,9180,4170,1823,613210,85363,100616211,146722,10747,6195,8936,8315,64718,83858,1476,11322,64410,11258,1742,5036,80301,54850,5609,55860,10913,11333,6406,23526,57162,4318,2633,3445,7077,221002,5534,100500842,7187,151888,8398,441864,4048,4012,136371,1278,4208,90933,3459,818,246,51135,926,10010,5720,161,8074,3385,2065,100616340,114548,3458,51433,6049,245973,644414,4773,3600,3635,53371,29927,3809,8915,55658,89858,10411,4049,89122,100847012,3075,1116,8352,51343,10484,9693,6773,23239,53358,2185,8566,6468,30849,10910,7462,55182,2665,51665,1793,727,3690,7726,114,10096,596,192669,3836,203068,3240,8086,2220,79132,51191,8778,114836,7292,57731,940,7328,1843,4790,3346,3557,533,2357,4775,149954,3383,153579,4680,84868,302,11097,3101,6518,81930,8519,401258,23071,56244,5618,2668,3127,56888,1982,9902,6885,3429,245927,8649,9636,3120,10623,10818,716,83547,3572,374395,140453,64926,8744,1604,199675,5328,5292,5580,3932,475,1088,1235,7325,5329,5714,5223,10695,9844,6778,6416,6515,11128,23385,3304,1154,1378,399473,117854,4277,5817,3428,79155,3606,10043,401036,997,8395,5371,523,3805,9450,5701,5912,140459,2250,1849,2069,2214,8560,3837,9491,3394,1062,8804,4205,5440,4846,1510,81030,23511,90025,3455,3347,3556,2904,64750,23308,10489,5660,79671,81603,2162,5869,10454,8454,7174,8773,7323,6352,56300,9261,2547,146330,7534,1848,142678,57554,917,2588,84937,23352,466,23200,79908,3449,7099,3725,80329,29127,23608,5528,5553,3702,644076,3911,55176,717,5605,693215,3562,178,79837,3082,6199,10487,100847079,1938,970,27006,7704,338324,55,5896,8995,5971,290,1437,90865,2920,7414,5155,10584,196527,54778,78989,210,2932,23545,613211,526,1027,221,1672,941,9145,5693,79023,3669,7098,3448,3111,93978,1493,55521,11126,118430,727897,5529,7450,7525,2246,1072,8993,3594,9545,1265,6850,54620,11213,4692,115,10071,330,6710,353376,5603,79923,642,89953,84261,6891,996,23198,390594,5878,80176,916,160,933,10273,55313,5005,64145,968,8655,10890,4064,4313,5879,8503,3904,27181,109,7334,5695,3588,23317,197358,3320,4599,9666,1828,57542,713,84876,23376,5037,117159,10385,7249,63916,11059,51082,5806,201294,5245,3162,122665,64333,11275,29110,5153,56667,57119,147945,143662,154214,53833,4179,2248,9867,2212,23114,27297,409,79902,719,973,834,6477,3824,5600,26281,7311,103,939,23250,1435,153090,150726,4627,54518,356,8452,7520,26578,128859,6317,9140,27161,1850,8767,2249,4831,64223,9725,23191,4317,3586,4620,56954,55905,92747,26268,340061,285231,6921,1508,51666,3574,4939,54509,9320,84292,9588,161742,140460,142685,64581,2261,5211,80143,8718,5526,8742,10952,5289,3134,1315,27036,114876,2992,5591,2676,163351,80263,10095,1444,7431,6672,7132,55284,10450,5836,51382,11009,6196,23601,26235,55294,51143,10324,107,26523,84282,246778,7096,4938,51088,3934,5690,115650,1509,7428,930,163,9641,9818,8907,3615,5787,9870,22914,6396,7226,1915,2253,5434,730,23765,23643,9039,147700,6233,3559,3592,2720,1513,9021,7291,910,4689,148581,388697,5443,4233,84639,2066,3386,3558,8924,3636,27040,7327,3684,5663,5771,54756,3164,4688,338339,51411,81622,2534,7320,529,57761,10006,965,10671,208,171568,1398,7332,3902,8916,1846,1230,2358,2323,26153,353,999,84659,23593,8722,175,3084,10577,112744,23636,1515,1270,7010,317,6708,283455,3835,6047,8737,9520,50604,2255,3123,1778,26007,3676,26249,10859,6776,284,27071,814,3958,9972,1113,976,4982,7189,7867,5728,7412,3608,6709,919,801,130120,3426,9246,9830,245909,2934,2549,130340,29949,947,55175,3693,6351,9051,118424,835,84861,154881,7220,6737,131450,3838,23218,22931,89790,7326,50852,9114,10425,720,3839,3312,4793,2353,4296,100528032,3553,5702,51297,2548,58485,1847,3605,3630,2512,51434,23035,55706,51619,729230,3821,9761,7314,6793,1519,23014,100616150,9550,5819,5682,5617,8887,5588,8968,729,5547,10396,5320,3929,9402,8396,11118,6279,5068,8784,3695,23480,51320,661,5610,6777,23279,5291,2264,89777,29108,10152,115361,3093,6278,114907,3603,23225,3456,121260,394263,1981,5641,6300,9690,5594,8554,1118,1441,5589,943,6590,84231,23396,6282,348995,51816,1522,200845,5606,388698,327,4210,84514,140461,5870,3726,81844,79791,23327,10788,8672,4282,10120,2171,4254,100616453,80228,81793,4718,2243,6597,10293,226,4973,946,54106,127247,728358,1977,6657,8437,6614,51719,8139,200958,10225,6892,80196,4650,1213,1832,10068,5156,120425,25,2896,11074,10533,55958,6935,7294,63891,25897,83716,11004,80331,2821,163702,23108,3587,929,9616,5527,634,731,4050,10762,3112,51676,6363,57020,3667,245930,64167,911,51606,122706,1671,5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P8A1,PLA2G2A,LBP,GRAP2,PIP4K2B,BTN3A2,S100A8,REG3A,TNFRSF18,ITGB7,SEC61G,MEX3C,POLR3D,EIF2AK2,STAT5B,NUP160,PIK3CB,FGFR4,SERPINB12,PYCARD,ABI2,GBP4,UBE2K,S100A7,FBXO32,IL16,NUP210,IFNB1,SLC15A4,MUC21,EIF4G1,LGMN,MAPK12,UBE3C,MAPK1,PIAS1,CHIT1,CSF3R,PRKCSH,TNFRSF8,SLPI,TRAF7,PIP5K1C,S100A11,NUP43,ADA2,CTSZ,KCTD6,MAP2K3,FLG2,APEH,MEFV,GHDC,ASB8,RAB6A,JUNB,TRIM56,FBXO31,NEDD4L,IQGAP2,EIF4G3,MIF,ACTR1B,FABP5,KITLG,MIR4687,ORAI2,TLR10,NDUFC2,FGA,SMARCA4,TRAIP,ALDOA,OLR1,SIGLEC6,TLR9,ASB17,DEFA1B,EIF4E,SOX2,RASAL1,SIGLEC1,CAB39,GAN,MUC20,CD96,TAPBP,RNF34,MYO9B,CLTC,DSP,IL18BP,PDGFRA,JAML,ABL1,GRN,TRIM31,ATG7,KLHL9,ZEB1,TXK,RNF123,RNF19A,CRISPLD2,KIF2C,DNAJC5,GPI,IFNLR1,RAP1GAP2,IL10RA,CD14,RNF7,PPP2R5C,CEACAM1,C8A,LTB,NUP50,HLA-DOB,ASB2,CCL19,VPS35L,IRS1,DEFB116,ERAP2,CD1C,ATP6V1H,PSMB11,DEFA6,PPP3CB,DERA,IRF2,ERAP1,GSK3A,ARPC5,KIFAP3,ALOX5,UBE2E3,ACTN2,TP53,TRIM69,LTF,CD4,SKP1,LTN1,IFNA2,BRI3,PSMB8,C6orf120,CSF2RB,FBXO2,CDC20,H3C11,SYNGAP1,PTGS2,IL22,BRWD1,GSDMD,BST1,SPTBN5,CAMK2A,RAPGEF4,FBXO17,FBXW2,PTPRA,TLR2,ATG5,CANT1,FBXL21P,GRIN2D,IRF9,IL1R1,FBXL5,TAP1,NRG3,RNF138,AKAP9,ITGB1,NFAM1,NCAM1,SPTBN1,MAPK3,SDCBP,LILRA1,DCTN1,PRKAR2B,FBXO7,RBCK1,GBP5,PDE1C,FLNB,KIF5A,IFITM3,SQSTM1,NRTN,NFKBIE,MOV10,CD40,RNF213,CST3,ATP6V1C1,S100A9,KIF15,CTSS,PSMD14,MIR3614,IFNGR2,DCTN2,NEFL,KIF5B,MAN2B1,FTH1,LMO7,IL1R2,ANAPC10,RASA2,ARPC3,SLC27A2,CD81,TRIM62,PI3,GZMM,KRT1,VRK3,RBBP6,LAMTOR1,KIR3DL2,ITGB2,SKP2,CD200,TMEM30A,CD101,RELA,IFNA5,CLEC12A,TNFSF15,ASB16,PRKN,UBE2C,POLR3B,CD274,H3C13,GAB2,ITPR2,IL6,POM121,FRS3,PPIA,MT2A,FGFR2,PTAFR,CDC42,PSME3,RETN,TNFSF8,ELOB,TNFRSF9,LONRF1,BATF,POLR3K,SEC24B,RANBP2,DEFB125,CIITA,TRIM39-RPP21,PGLYRP3,EGFR,MYC,ART1,CD300LG,SIGLEC11,CD59,ITLN1,HLA-DQA1,TRIM63,IRF4,ARIH1,PPP3CA,KIF3A,LNX1,SAMHD1,PDPK1,IL5RA,ITPR1,ECSIT,RNASE2,UBR1,CTSG,ARMC8,C1orf35,TNFRSF4,GH1,AGER,POLR2L,FBXO44,H3C8,BPIFB2,HRAS,CXCL10,UBE2V2,ADCY4,TNFRSF17,HSPA6,PSMD1,CD53,STBD1,CAPN1,PRKACB,FUCA1,TREML2,TXNDC5,TRIM38,FGF6,RASGRP3,PSMC1,KLC1,SIGLEC16,DSN1,AGO4,DCTN4,CLEC10A,ARRB1,C3,FAF2,IRAK2,ATP6V0E2,RAET1E,IL13,FBXO27,GNS,FGB,PAFAH1B2,CYLD,IRS2,NCR3LG1,ICOS,DNM1,PELI3,HLA-B,SRP14,ANAPC4,IL17RC,EEA1,GFRA4,HECTD1,TRIM32,PRKCE,RASGRP4,CHUK,PLPP4,PPP2R1B,GOLGA7,NFATC1,VAPA,EDARADD,WIPF2,SH3RF1,CFHR3,BST2,PGM1,CXCR2,CD86,DEFB105A,STAT1,MYD88,PIGR,BTN1A1,H3C6,CLEC2B,IFIT3,TXN,PIP4K2A,IL9,SVIP,PLD4,PTPN4,KPNA7,ANAPC1,TREM1,PPP2R1A,PGM2,CD63,STOM,FBXO6,DEFA4,FCER1G,PLD1,CCL20,IL31RA,PRR5,RAF1,FGF18,PSMA6,TRIM25,MASP1,CLEC4C,UBE3A,CKAP4,MPO,PSMC6,LYN,UBR2,DOK3,PRKACA,IL36B,PIK3AP1,WASF2,MAPKAP1,B4GALT1,IMPDH1,UBE2D2,FADD,UBE2R2,NCKIPSD,TYROBP,MIR5010,CNKSR1,ACTR2,BAIAP2,KIF20A,MAP3K8,SOCS5,KBTBD8,HLA-G,MALT1,PIK3R1,TRIM2,BTBD1,RNF125,SRC,ADCY5,CD79B,CAMK2B,RNF25,CCL3L3,IKBKB,IL7R,ASAH1,STX4,CBLB,IP6K2,JAK3,NHLRC3,NFKB2,IL11RA,CSK,TREML4,HLA-C,KLHL20,DUSP16,PPP2CA,LILRA2,RHOA,DIAPH1,SIGLEC9,SPRED2,CALM3,BTRC,GLIPR1,DEFB135,ARG1,CD33,RICTOR,NRG4,LPCAT1,CLCF1,MADCAM1,REL,FN1,H3C2,ADAM17,FCGR2C,CASP4,TRIM29,NLRC4,STK11IP,CUL7,TTR,VAV2,HPSE,BCL2L1,IFNA21,H3C14,AP1G1,NUP155,SH2B1,AZU1,CRACR2A,CASP8,PAG1,ICAM5,KLHL21,HECTD3,POLR3G,IL15RA,PLCG2,SCAMP1,KIR2DL1,PSMA5,TNRC6C,TOLLIP,FBXL13,AKT3,PIK3CD,MS4A2,SIPA1,HLA-E,HIF1A,FYB1,LRRFIP1,ANXA1,S1PR1,OLFM4,TRIM34,EVL,FBXL20,IFNL2,FBXW8,MMP1,SLAMF7,RORA,P2RX1,PAK1,RIGI,PDE1A,SMURF1,RAB14,CFD,TLR6,UBE2Z,POU2F1,ITGAL,HMOX2,PRKAR2A,DYNC1I1,CCL3,UBA7,ARTN,DEFB129,TXLNA,ATP6V0E1,CD74,FCGR1BP,CTSL,CCL3L1,PKM,PGLYRP2,SOCS2,UBE2Q1,CLTA,S100P,CAMK2D,IL18RAP,MAPK10,IL4,FBXL7,PGLYRP4,QSOX1,FGF9,IL17RE,SIRPA,ADAM10,MRE11,LAMP1,RAP1GAP,FGR,PSMD11,ITGAV,AKT1S1,BTC,CASP3,HERC1,FBXO22,AP1B1,RPS6KA5,PSMB4,SH3GL2,C5AR1,NUP98,MAPK7,BPI,PSMA8,GM2A,CLU,PSMD4,PSPN,MBL2,TRIM35,EIF4A3,BLK,PPP5C,ELANE,TNRC6B,CREB1,MAPK8,TNFSF14,ZNRF2,ASB3,CRISP3,GUSB,COMMD9,CD300A,CRTAM,RNASE3,KRAS,RAP1B,PLD3,IL36A,ASB13,EGF,TICAM1,B2M,CTSC,TNFAIP6,NRG2,BIRC5,NOD2,IL27RA,DCAF1,DNM2,MAVS,FGG,DEFB110,STX3,GRIN2C,MX2,CCNF,HLA-DQB1,IFNAR1,IRF3,IDH1,DEFA5,RORC,KBTBD6,CCND1,DEFB112,SLC44A2,IGF2R,RIPK3,CD300LB,DEFB108B,HERC4,CALM2,CD36,ZAP70,GPR84,PSMD7,HVCN1,TPR,PPM1B,OASL,ASB14,DTX4,IFITM2,TNFRSF13B,KLC2,RET,ATP6V0A4,KIR2DL3,MGAM,POM121C,MAPK14,MANBA,XDH,DHX36,PIP5K1A,PKP1,IL2RB,SEC31A,RAP1A,DEFB115,PTGES2,TRIM10,MYLIP,IL5,IRAG2,TNFRSF1B,IFNA4,FGF17,CDK13,FCGR3B,SERPINA1,HLA-DQA2,PROS1,MYO5A,FBXL22,PPL,IL17RB,CUL2,KIR3DL1,PSMD9,ITGAX,UBE2E1,SELL,NUP107,MS4A3,VASP,CCR5,TRIM37,RASA1,IER3,FGF19,NUP214,P2RX7,AP1M2,AOC1,KIF3C,CPNE3,GRIN2A,WASF3,UBE2Q2,UBC,DYNC1LI2,CALML5,PRKCA,CD47,IFI6,CANX,C1QA,FCGR2B,TLR5,FBXO15,TAB2,SHC1,HBEGF,POLR3E,NCK1,CREBBP,KLRG1,KPNA4,PRKCB,HECW2,DEFB127,SURF4,SPTBN2,BPIFA2,RNF216,BTN2A1,ATP6V1G3,SAA1,MIR1281,MYO10,SIGLEC14,IL20RA,RHOU,VAV1,UBE2V1,DNAJC3,PSMB6,PEA15,PDCD1LG2,SIRPB1,C4BPB,CTF1,DEFA1,FCGR1A,ORM1,LAMTOR2,CD207,CPNE1,TNFRSF11A,PTPRN2,DHX9,EIF4E3,KL,MUC4,LCP2,AMPD3,QPCT,RNF182,C5AR2,PAK2,TNF,IFNA1,HACE1,TMBIM1,TNFSF13B,CD1D,MGRN1,IL12RB2,WIPF3,CXCR1,HLA-DRA,IL1RL1,CAPZA2,PLD2,TREX1,ARL8A,IL6R,ACAA1,HLA-A,SLCO4C1,CXCL1,FCER2,POLR1C,PIK3CA,C8B,CFB,PRKCG,TRIM68,ADGRG3,RNF130,PRKACG,PSMD2,SNAP25,ARSB,ULBP3,SH2D1B,SIGIRR,MUC2,BCL6,COTL1,HECTD2,NCKAP1,ARPC2,RAPGEF1,SAR1B,VCP,RANBP9,DEFB126,PDGFA,C1QC,IFIH1,ATP6V0A1,OPRD1,FLT3,MMP3,NCF1,FSCN1,LAIR1,FGL2,RASGRP1,RNF41,MAP2K1,GMFG,NCR2,TXNIP,KLRB1,LIFR,KIF11,CD93,CAND1,TRIM46,FGF7,PLAC8,PCBP2,VAV3,IL12B,BTN3A1,JAK1,RCHY1,FUCA2,CYSTM1,TSPAN14,SERPINB10,ACLY,CTSH,MUC16,NCKAP1L,UBE2J1,IFIT2,OAS3,H3C10,PYGB,TCN1,CCT2,EIF4E2,RNF144B,BRAF,DET1,PNP,CARD11,TRIM3,RNASEL,VAMP3,IFNA7,CD44,MMP25,CAMP,CNTFR,BLNK,OPRM1,NUP35,RBX1,CHRNB4,C4BPA,CD1A,CALR,H3C1,LIMK1,FOXO1,FBXL14,SEC24C,UBE3B,UBE4A,IRF6,TMT1A,YPEL5,CXCL8,HLA-H,FOXO3,UBA6,CLEC2D,PIK3R2,C9,CD300E,SRMS,GRB2,GFRA1,PPP2CB,PRSS3,MARK3,CD3D,APOB,TGFB1,CD300C,ACTR1A,HLA-DMB,SEC24A,CCL11,MAP3K14,CYB5R3,FOLR3,GBP2,NFKBIA,SOS1,KIF23,NCR3,FBXW11,KLRF1,EIF4A2,CCT8,ABCA13,SERPINA3,LILRB4,IL1A,MUC6,PTPN22,SEC24D,CUL5,MNDA,TYK2,TRIM9,MUC7,GRK2,ITPR3,CDA,RASGRF2,ASB5,MYO1C,NCR1,LIF,NOS1,PTPN6,PTPRJ,DCTN5,UBE2D1,IRF1,ATP6V1B1,AP1S1,PTPN1,CEP290,FCER1A,HLA-DMA,GCA,PLCG1,MGST1,PIN1,FBXO10,ADGRE3,JAK2,NEU1,PSMA4,MAP3K1,ADCY2,LYZ,ATP8B4,KBTBD7,ARF1,GNLY,UBA5,CEBPD,CEACAM3,EBI3,DNM3,PSMD12,TRIM71,RSAD2,GATA3,RNASE6,VEGFA,ARPC1A,STAT3,KCNAB2,PRKAR1B,FGFR1,IFNL1,NUP88,ANAPC11,SERPINB1,CRLF1,BTN3A3,IL34,FRK,SEH1L,MICA,HSPA5,FBXL18,GGH,TIRAP,SHC2,AKT1,DUSP10,ARPC4,CDC23,PSMB3,IST1,PRG3,EGR1,UBE2O,HLA-DPA1,SOCS1,MTOR,PRTN3,LRSAM1,ENPP4,SEC22B,AHSG,CASP10,HBB,PTPN11,IL17C,ITGA2B,LEAP2,NUP93,PSMD13,EPX,IL4R,CXADR,RASGRP2,FBXO30,LRG1,CRP,PSMD6,XAF1,CLEC4E,THEM4,FCN1,SERPINB6,ICAM2,ERBB2,MAPK9,PRKAR1A,ATP6V0D2,NLRC5,NUP133,IL18R1,CAT,C1R,TNFSF11,SLC11A1,CCL2,RNASET2,RNF19B,IL23R,IL32,DEFB107A,NRAS,DBNL,INSR,HEXB,SEM1,DUSP2,NLRP1,SPSB4,KIF2A,PANX1,VNN1,PECAM1,SUMO1,CMTM6,ATF2,RAB37,KIF2B,S100A12,NEDD4,RAB3A,IL22RA1,DEFB132,RNF14,UBOX5,CD300LD,RAB31,TCIRG1,MME,ADCY7,VAMP8,DOCK2,STIM1,IL1RL2,KIF4B
R-HSA-109704	PI3K Cascade	0.0097768025963078	-4.62774278128248	79	76	0.00841266327208324	9034	10285	10670,54106,2263,5571,28956,2251,5563,58528,2255,27006,9365,26281,2260,64121,6009,10818,2261,2253,2247,84335,6794,9965,7248,8649,2250,5289,5565,3667,6194,57521,2246,2549,7529,2248,117145,30849,81617,55004,7249,2254,5170,92335,5781,8817,5290,8822,2885,64223,5494,51422,53632,57761,2249,5562,208,1981,55437,8660,8074,1978,2475,389541,2252,5296,6198,5291,2264,1977,10542,1975,5564,29904,5140,51719,207,5295	RRAGA,TLR9,FGFR2,PRKAG1,LAMTOR2,FGF6,PRKAA2,RRAGD,FGF10,FGF22,KL,FGF20,FGFR1,RRAGC,RHEB,FRS2,FGFR3,FGF8,FGF2,AKT1S1,STK11,FGF19,TSC1,LAMTOR3,FGF5,PIK3C3,PRKAB2,IRS1,RPS6,RPTOR,FGF1,GAB1,YWHAB,FGF3,THEM4,PIK3R4,CAB39L,LAMTOR1,TSC2,FGF9,PDPK1,STRADA,PTPN11,FGF18,PIK3CA,FGF17,GRB2,MLST8,PPM1A,PRKAG2,PRKAG3,TRIB3,FGF4,PRKAA1,AKT2,EIF4G1,STRADB,IRS2,FGF23,EIF4EBP1,MTOR,LAMTOR4,FGF7,PIK3R2,RPS6KB1,PIK3CB,FGFR4,EIF4E,LAMTOR5,EIF4B,PRKAB1,EEF2K,PDE3B,CAB39,AKT1,PIK3R1
R-HSA-112399	IRS-mediated signalling	0.0101199384422178	-4.59324769792612	294	271	0.0299977861412442	9034	10285	23198,88,7979,1844,10125,143471,5710,5571,122706,4893,58528,6710,5692,2255,685,7010,84335,6708,3690,5154,10048,7248,283455,3667,5708,115727,57521,2246,53358,9861,117145,2064,5717,5527,3084,30849,5519,801,5245,1950,6709,5037,7249,5894,8817,9542,5687,51332,815,53632,5518,5786,3716,3845,5908,284,8831,1843,2252,5695,1978,5623,5604,10542,57731,5696,1439,5536,408,9048,1437,4233,54106,3082,25780,28956,2251,2243,9365,27006,3559,4254,5700,2260,5718,5528,2253,5605,6233,3562,5707,8682,84078,5694,3265,5781,100847012,3674,2254,64096,7450,9693,1846,5529,5719,5290,51422,817,2534,5693,57761,208,8660,5156,27040,8074,5691,2065,389541,2475,54756,3558,6198,8437,818,2066,7414,1977,5155,25759,207,51719,2244,11221,5720,5159,7316,2675,2263,2069,10817,5563,2903,9491,10197,2676,64121,5923,2261,5701,2247,161742,2335,2250,1849,5289,9965,6654,5526,5921,200734,808,84292,145957,7529,5715,5525,5682,5594,1848,5170,3568,3717,5685,221002,5494,6712,1742,5690,5686,1981,55437,1839,1956,8315,10156,2264,5291,5704,5564,2904,5924,6464,152559,9978,5713,10256,10670,64926,153090,4902,5684,805,26281,5699,7311,6009,5595,10818,409,10142,2668,2905,5565,6794,6711,8649,8826,4684,673,6194,3815,5711,2549,2906,2248,10718,5706,81617,2266,55004,80824,1445,92335,4140,7314,8822,5515,3718,5922,4296,2885,64223,2674,5906,5747,1850,2249,9462,4763,1847,399473,5562,3567,5702,5516,5714,816,3560,4747,5296,5979,8452,1975,54518,5698,10213,5140,6714,29904,5295	PSME4,ACTN2,SEM1,DUSP2,RASGRP1,PSMA8,PSMD4,PRKAG1,PSMB11,NRAS,RRAGD,SPTB,PSMB4,FGF10,BTC,TEK,AKT1S1,SPTA1,ITGB3,PDGFA,RANBP9,TSC1,KSR2,IRS1,PSMD2,RASGRP4,RPTOR,FGF1,SHC3,PSMD6,THEM4,ERBB2,PSMD11,PPP2R5C,NRG1,PIK3R4,PPP2R1B,CALM1,PHB1,EGF,SPTAN1,PEBP1,TSC2,RAF1,FGF18,NRG2,PSMA6,SPTBN5,CAMK2A,PRKAG3,PPP2R1A,PTPRA,JAK1,KRAS,RAP1B,ANGPT1,SYNGAP1,DUSP1,FGF7,PSMB7,EIF4EBP1,PSPN,MAP2K1,LAMTOR5,SPTBN4,PSMB8,CSF2RB,PPP5C,ARRB1,ARTN,CSF2,MET,TLR9,HGF,RASGRP3,LAMTOR2,FGF6,FGA,KL,FGF22,IL2RA,KITLG,PSMC1,FGFR1,PSMD12,PPP2R5D,FGF8,MAP2K2,RPS27A,IL3,PSMD1,PEA15,KBTBD7,PSMB6,HRAS,PTPN11,MIR5004,ITGA2B,FGF9,GFRA4,VWF,RAPGEF2,DUSP4,PPP2R5E,PSMD13,PIK3CA,PRKAG2,CAMK2D,FYN,PSMB5,TRIB3,AKT2,IRS2,PDGFRA,LAT,FGF23,PSMB3,ERBB3,LAMTOR4,MTOR,IL17RD,IL2,RPS6KB1,RASAL1,CAMK2G,ERBB4,VCL,EIF4E,PDGFB,SHC2,AKT1,CAB39,FGB,DUSP10,PSME1,PDGFRB,UBC,GFRA2,FGFR2,EREG,FRS3,PRKAA2,GRIN2A,PSMF1,PSME3,GFRA3,RRAGC,RASGRF1,FGFR3,PSMC2,FGF2,SPRED1,FN1,FGF5,DUSP7,PIK3C3,FGF19,SOS1,PPP2R5B,RASA1,SPRED2,CALM3,WDR83,NRG4,YWHAB,PSMD9,PPP2R5A,PSMA1,MAPK1,DUSP6,PDPK1,IL5RA,JAK2,PSMA4,RASGEF1A,PPM1A,SPTBN2,DLG4,PSMB2,PSMA5,EIF4G1,STRADB,HBEGF,EGFR,BRAP,RASA4,FGFR4,PIK3CB,PSMC4,PRKAB1,GRIN2B,RASGRF2,SHC1,PAQR3,RBX1,PSMD7,CNKSR1,RRAGA,RASAL3,DAB2IP,NRTN,PSMA3,CALM2,FGF20,PSMB10,UBA52,RHEB,MAPK3,FRS2,ARRB2,AKAP9,GDNF,GRIN2C,PRKAB2,STK11,SPTBN1,LAMTOR3,IQGAP1,NCAM1,BRAF,RPS6,KIT,PSMD5,GAB1,GRIN2D,FGF3,NRG3,PSMC6,CAB39L,FGG,LAMTOR1,DUSP16,CSK,STRADA,MARK3,UBB,FGF17,PPP2CA,JAK3,RASA2,MAP3K11,GRB2,MLST8,GFRA1,RAP1A,PTK2,DUSP8,FGF4,RASAL2,NF1,DUSP5,SPRED3,PRKAA1,IL5,PSMC3,PPP2CB,PSMD8,CAMK2B,IL2RB,NEFL,PIK3R2,RET,CUL3,EIF4B,APBB1IP,PSMB9,PSMD14,PDE3B,SRC,EEF2K,PIK3R1
R-HSA-6804757	Regulation of TP53 Degradation	0.0105965662305655	-4.54722527085687	35	35	0.00387425282266991	9034	10285	6233,2475,11200,890,207,253260,6446,7874,80196,5527,5519,8900,4193,7314,55615,5515,10000,900,7157,7316,117584,5170,472,7311,9099,1616,5516,208,1017,1029,64223,5518,79109,983,4194	RPS27A,MTOR,CHEK2,CCNA2,AKT1,RICTOR,SGK1,USP7,RNF34,PPP2R5C,PPP2R1B,CCNA1,MDM2,UBB,PRR5,PPP2CA,AKT3,CCNG1,TP53,UBC,RFFL,PDPK1,ATM,UBA52,USP2,DAXX,PPP2CB,AKT2,CDK2,CDKN2A,MLST8,PPP2R1A,MAPKAP1,CDK1,MDM4
R-HSA-1227986	Signaling by ERBB2	0.0106796226164261	-4.53941778161503	51	50	0.00553464688952845	9034	10285	1839,1956,2065,207,6714,5295,11140,6464,4145,2066,10193,10273,7525,7314,1729,387,9542,5290,10000,5335,1950,51072,3845,208,5753,3320,2885,2534,6233,6654,685,26469,9101,3265,145957,10718,2064,5782,3084,55914,2549,5581,5580,8065,100302213,5578,7316,7311,4893,2069	HBEGF,EGFR,ERBB3,AKT1,SRC,PIK3R1,CDC37,SHC1,MATK,ERBB4,RNF41,STUB1,YES1,UBB,DIAPH1,RHOA,NRG2,PIK3CA,AKT3,PLCG1,EGF,MEMO1,KRAS,AKT2,PTK6,HSP90AA1,GRB2,FYN,RPS27A,SOS1,BTC,PTPN18,USP8,HRAS,NRG4,NRG3,ERBB2,PTPN12,NRG1,ERBIN,GAB1,PRKCE,PRKCD,CUL5,MIR1181,PRKCA,UBC,UBA52,NRAS,EREG
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	0.0107120934221889	-4.53638194936646	65	63	0.00697365508080584	9034	10285	2534,2249,2885,2254,1950,930,5781,5293,8817,9542,5290,8822,7409,5155,2066,2264,5291,3932,5295,50852,940,2065,8074,1956,5156,1839,8660,5296,8503,941,2252,29851,2251,2069,3082,2263,2260,10818,4254,27006,2255,9365,26281,942,5159,4233,2246,2549,3815,3084,2064,145957,10718,2248,2253,2247,2261,685,118788,3667,9965,5154,2250	FYN,FGF4,GRB2,FGF9,EGF,CD19,PTPN11,PIK3CD,FGF18,NRG2,PIK3CA,FGF17,VAV1,PDGFB,ERBB4,FGFR4,PIK3CB,LCK,PIK3R1,TRAT1,CD28,ERBB3,FGF23,EGFR,PDGFRA,HBEGF,IRS2,PIK3R2,PIK3R3,CD80,FGF7,ICOS,FGF6,EREG,HGF,FGFR2,FGFR1,FRS2,KITLG,FGF22,FGF10,KL,FGF20,CD86,PDGFRB,MET,FGF1,GAB1,KIT,NRG1,ERBB2,NRG4,NRG3,FGF3,FGF8,FGF2,FGFR3,BTC,PIK3AP1,IRS1,FGF19,PDGFA,FGF5
R-HSA-2219528	PI3K/AKT Signaling in Cancer	0.0111830372859793	-4.49335717677556	90	86	0.00951959264998893	9034	10285	4233,2308,842,6199,2260,10818,4254,9365,27006,26281,2251,79109,3082,2253,118788,10718,2248,2549,3815,5290,8822,2254,5781,208,2534,2249,64223,2885,5296,3164,2475,941,29851,2065,2309,8074,5156,2932,1027,8660,5295,50852,207,4193,5155,2066,1026,3932,5159,2255,2931,942,2069,2263,3667,9965,5154,2250,84335,2247,685,2261,3084,1147,2064,145957,253260,2246,9542,8817,55615,7409,5170,7249,930,1950,10000,5293,8503,2252,1956,1839,1385,940,5291,2264	MET,FOXO1,CASP9,RPS6KB2,FGFR1,FRS2,KITLG,KL,FGF22,FGF20,FGF6,MAPKAP1,HGF,FGF8,PIK3AP1,NRG3,FGF3,GAB1,KIT,PIK3CA,FGF17,FGF9,PTPN11,AKT2,FYN,FGF4,MLST8,GRB2,PIK3R2,NR4A1,MTOR,CD80,ICOS,ERBB3,FOXO3,FGF23,PDGFRA,GSK3B,CDKN1B,IRS2,PIK3R1,TRAT1,AKT1,MDM2,PDGFB,ERBB4,CDKN1A,LCK,PDGFRB,FGF10,GSK3A,CD86,EREG,FGFR2,IRS1,FGF19,PDGFA,FGF5,AKT1S1,FGF2,BTC,FGFR3,NRG1,CHUK,ERBB2,NRG4,RICTOR,FGF1,NRG2,FGF18,PRR5,VAV1,PDPK1,TSC2,CD19,EGF,AKT3,PIK3CD,PIK3R3,FGF7,EGFR,HBEGF,CREB1,CD28,PIK3CB,FGFR4
R-HSA-1489509	DAG and IP3 signaling	0.0120694889367422	-4.4170745863812	34	34	0.00376355988487934	9034	10285	5153,112,5582,5580,5576,108,5335,5578,801,3708,5137,113,5577,5575,805,5136,114,5567,109,107,115,814,3709,1385,5573,196883,10768,5566,111,3710,5581,156,808,5568	PDE1B,ADCY6,PRKCG,PRKCD,PRKAR2A,ADCY2,PLCG1,PRKCA,CALM1,ITPR1,PDE1C,ADCY7,PRKAR2B,PRKAR1B,CALM2,PDE1A,ADCY8,PRKACB,ADCY3,ADCY1,ADCY9,CAMK4,ITPR2,CREB1,PRKAR1A,ADCY4,AHCYL1,PRKACA,ADCY5,ITPR3,PRKCE,GRK2,CALM3,PRKACG
R-HSA-3371556	Cellular response to heat stress	0.0122286216349443	-4.40397603923685	89	85	0.00940889971219836	9034	10285	64223,9529,817,51182,815,79023,3320,10049,100302237,3304,9261,472,10728,9530,6767,9818,5594,11097,6119,55706,23411,9688,818,23279,3309,3326,23511,100101267,23165,9531,5903,259217,816,2932,3312,22824,1387,51501,23225,9972,2475,53371,9883,8021,7531,3306,57805,4927,3308,91582,2033,5595,3311,9532,7175,4928,129401,3305,8086,81929,9631,27000,573,57521,348995,3337,6117,23636,10762,57122,545,3281,116835,1915,84335,6118,3310,10808,6782,55746,2288,79902,7266,3313,7415	MLST8,BAG5,CAMK2D,HSPA14,CAMK2A,NUP37,HSP90AA1,DNAJB6,MIR1281,HSPA1B,MAPKAPK2,ATM,PTGES3,BAG4,ST13,NUP58,MAPK1,NUP42,RPA3,NDC1,SIRT1,NUP93,CAMK2G,NUP160,HSPA5,HSP90AB1,NUP188,POM121C,NUP205,BAG3,RANBP2,HSPA12A,CAMK2B,GSK3B,HSPA8,HSPA4L,CREBBP,HIKESHI,NUP210,NUP153,MTOR,NUP54,POM121,NUP214,YWHAE,HSPA2,CCAR2,NUP88,HSPA4,RPS19BP1,EP300,MAPK3,HSPA7,BAG2,TPR,NUP98,NUP35,HSPA1L,AAAS,SEH1L,NUP155,DNAJC2,BAG1,RPTOR,NUP43,DNAJB1,RPA1,NUP62,NUP50,NUP107,ATR,HSBP1,HSPA12B,EEF1A1,AKT1S1,RPA2,HSPA6,HSPH1,HSPA13,NUP133,FKBP4,NUP85,DNAJC7,HSPA9,VCP
R-HSA-2404192	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	0.0131495398959257	-4.33136850987348	299	275	0.0304405578924065	9034	10285	5694,84078,8682,3265,2253,5718,5528,5707,3562,5605,6233,25780,2251,28956,3082,2260,5700,3559,4254,27006,9365,2243,408,54106,4233,1437,9048,5155,1977,7414,2066,818,6198,8437,3558,5720,2244,11221,207,51719,25759,2065,8074,27040,5691,5156,8660,54756,2475,3480,389541,57761,5693,2534,817,51422,208,2254,64096,100847012,3674,5781,5290,5529,5719,7450,1846,9693,9861,53358,2246,57521,115727,5708,5519,30849,5717,3084,5527,2064,117145,84335,7010,685,3667,7248,283455,5154,10048,3690,6708,6710,58528,122706,4893,5571,2255,5692,1844,7979,88,23198,5710,3479,143471,10125,5604,10542,5623,5536,1439,5696,57731,1843,8831,284,5695,1978,2252,53632,5518,815,51332,5908,3845,3716,5786,7249,5037,1950,6709,5245,801,5687,8817,9542,5894,2906,2549,5711,3815,6194,2266,5706,81617,10718,2248,2905,10142,2668,409,673,4684,8826,8649,6711,6794,5565,805,5684,5595,10818,6009,7311,26281,5699,8483,64926,10670,10256,5713,9978,152559,4902,153090,1975,5698,54518,8452,5979,5295,6714,29904,10213,5140,816,5714,5296,4747,3560,9462,2249,1850,5747,5906,64223,2674,2885,4296,5922,3718,5516,5702,5562,3567,399473,4763,1847,4140,92335,1445,80824,55004,5515,8822,7314,808,200734,5682,5715,5525,145957,7529,84292,2335,2247,161742,5701,2261,5921,5526,6654,9965,5289,2250,1849,10817,5563,2069,2263,64121,5923,2676,10197,9491,2903,5159,7316,2675,5564,5704,5291,2264,10156,5924,6464,2904,1956,1839,55437,8315,1742,3481,6712,5494,1981,5686,5690,5170,3568,1848,5594,221002,5685,3717	PSMB6,KBTBD7,PEA15,HRAS,FGF8,PSMD12,PPP2R5D,PSMD1,IL3,MAP2K2,RPS27A,RASGRP3,FGF6,LAMTOR2,HGF,FGFR1,PSMC1,IL2RA,KITLG,FGF22,KL,FGA,ARRB1,TLR9,MET,CSF2,ARTN,PDGFB,EIF4E,VCL,ERBB4,CAMK2G,RPS6KB1,RASAL1,IL2,PSME1,FGB,DUSP10,AKT1,CAB39,SHC2,ERBB3,FGF23,LAT,PSMB3,PDGFRA,IRS2,IL17RD,MTOR,IGF1R,LAMTOR4,TRIB3,PSMB5,FYN,CAMK2D,PRKAG2,AKT2,FGF9,GFRA4,MIR5004,ITGA2B,PTPN11,PIK3CA,PPP2R5E,PSMD13,VWF,DUSP4,RAPGEF2,PSMD6,SHC3,FGF1,RPTOR,RASGRP4,PSMD2,PPP2R1B,PIK3R4,PSMD11,NRG1,PPP2R5C,ERBB2,THEM4,AKT1S1,TEK,BTC,IRS1,TSC1,KSR2,PDGFA,RANBP9,ITGB3,SPTA1,SPTB,RRAGD,PSMB11,NRAS,PRKAG1,FGF10,PSMB4,DUSP2,SEM1,ACTN2,PSME4,PSMD4,IGF1,PSMA8,RASGRP1,MAP2K1,LAMTOR5,PSPN,PPP5C,CSF2RB,PSMB8,SPTBN4,DUSP1,SYNGAP1,ANGPT1,PSMB7,EIF4EBP1,FGF7,PRKAG3,PPP2R1A,CAMK2A,SPTBN5,RAP1B,KRAS,JAK1,PTPRA,TSC2,PEBP1,EGF,SPTAN1,PHB1,CALM1,PSMA6,FGF18,NRG2,RAF1,GRIN2D,GAB1,PSMD5,KIT,RPS6,FGG,PSMC6,CAB39L,NRG3,FGF3,GRIN2C,AKAP9,GDNF,ARRB2,BRAF,NCAM1,IQGAP1,LAMTOR3,SPTBN1,STK11,PRKAB2,CALM2,PSMA3,MAPK3,FRS2,RHEB,UBA52,FGF20,PSMB10,CILP,RASAL3,RRAGA,CNKSR1,PSMD7,RBX1,PAQR3,NRTN,DAB2IP,EIF4B,PSMB9,APBB1IP,CUL3,RET,PIK3R1,SRC,EEF2K,PSMD14,PDE3B,CAMK2B,PSMD8,PIK3R2,NEFL,IL2RB,RASAL2,FGF4,DUSP8,PTK2,RAP1A,MLST8,GFRA1,GRB2,MAP3K11,RASA2,JAK3,PPP2CB,PSMC3,PRKAA1,IL5,SPRED3,NF1,DUSP5,MARK3,STRADA,CSK,DUSP16,LAMTOR1,PPP2CA,FGF17,UBB,CALM3,SPRED2,PSMA1,PSMD9,PPP2R5A,NRG4,YWHAB,WDR83,FN1,FGF2,SPRED1,PSMC2,FGFR3,RASA1,PPP2R5B,SOS1,FGF19,PIK3C3,FGF5,DUSP7,FRS3,PRKAA2,EREG,FGFR2,RRAGC,RASGRF1,GFRA3,PSME3,PSMF1,GRIN2A,PDGFRB,UBC,GFRA2,PRKAB1,PSMC4,PIK3CB,FGFR4,RASA4,RASGRF2,SHC1,GRIN2B,EGFR,HBEGF,STRADB,BRAP,DLG4,IGF2,SPTBN2,PPM1A,EIF4G1,PSMA5,PSMB2,PDPK1,IL5RA,DUSP6,MAPK1,RASGEF1A,PSMA4,JAK2
R-HSA-1474228	Degradation of the extracellular matrix	0.0138460491964458	-4.2797553436165	111	105	0.0116227584680097	9034	10285	4326,5340,1303,1515,100126326,1508,999,440854,5654,7092,136227,4327,3818,4325,4319,1310,6868,836,3915,85007,4320,1308,92291,726,164656,170692,1297,5644,5045,10893,4314,26254,63827,682,1991,1504,84570,4811,170690,4313,6696,4322,1509,1215,3912,831,9313,3909,7077,9507,4318,3918,8754,649,1511,3817,1634,3911,4312,823,84290,4321,960,147968,64386,56999,1306,1298,4323,50859,1307,176,1305,1513,7177,100422894,3914,23473,7093,1299,7373,1520,4324,91522,8751,824,1514,388743,5663,100616340,440387,9510,4317,5650,11095,825,10753,23385,11096,4316,102,2,11131,6650,3339	MMP17,PLG,COL12A1,CTSV,MIR936,CTSB,CDH1,CAPN14,HTRA1,TLL1,COL26A1,MMP19,KLKB1,MMP16,MMP10,COL19A1,ADAM17,CASP3,LAMC1,PHYKPL,MMP11,COL17A1,CAPN13,CAPN5,TMPRSS6,ADAMTS18,COL9A1,PRSS1,FURIN,MMP24,MMP3,OPTC,BCAN,BSG,ELANE,CTRB1,COL25A1,NID1,ADAMTS16,MMP2,SPP1,MMP13,CTSD,CMA1,LAMB1,CAST,MMP20,LAMA3,TIMP2,ADAMTS4,MMP9,LAMC2,ADAM9,BMP1,CTSG,KLK2,DCN,LAMA5,MMP1,CAPN1,CAPNS2,MMP12,CD44,CAPN12,MMP25,ADAMTS9,COL15A1,COL9A2,MMP14,SPOCK3,COL16A1,ACAN,COL13A1,CTSK,TPSAB1,MIR4260,LAMB3,CAPN7,TLL2,COL9A3,COL14A1,CTSS,MMP15,COL23A1,ADAM15,CAPN2,CTSL,CAPN8,PSEN1,MIR4758,CTRB2,ADAMTS1,MMP8,KLK7,ADAMTS8,CAPN3,CAPN9,NCSTN,ADAMTS5,MMP7,ADAM10,A2M,CAPN11,CAPN15,HSPG2
R-HSA-2428924	IGF1R signaling cascade	0.0138528768764973	-4.27926235120431	298	274	0.0303298649546159	9034	10285	1742,3481,6712,5494,1981,5686,5690,5170,3568,1848,5594,221002,5685,3717,5564,5704,2264,5291,10156,6464,5924,2904,1956,1839,55437,8315,5563,10817,2069,2263,64121,5923,2676,10197,9491,2903,5159,7316,2675,808,200734,5682,5715,5525,7529,145957,84292,2335,2247,161742,5701,2261,5921,5526,6654,9965,5289,2250,1849,9462,1850,2249,5747,5906,64223,2885,2674,4296,3718,5922,5516,5702,5562,3567,399473,4763,1847,4140,92335,1445,80824,55004,5515,8822,7314,54518,1975,5698,8452,5979,5295,6714,29904,5140,10213,816,5714,5296,4747,3560,805,5684,5595,10818,6009,7311,5699,26281,64926,10670,10256,5713,9978,152559,4902,153090,2906,2549,5711,3815,6194,2266,81617,5706,10718,2248,2905,2668,10142,409,673,4684,8826,8649,6794,6711,5565,53632,5518,815,51332,5908,3845,3716,5786,7249,5037,1950,6709,5245,801,5687,9542,8817,5894,10542,5604,5623,5536,1439,5696,57731,1843,8831,284,1978,5695,2252,58528,6710,4893,122706,5571,2255,5692,1844,7979,88,23198,5710,3479,143471,10125,9861,53358,2246,57521,115727,5708,5519,30849,3084,5527,5717,2064,117145,84335,7010,685,3667,283455,7248,10048,5154,3690,6708,57761,2534,5693,51422,817,208,64096,2254,100847012,3674,5781,5290,5529,5719,7450,9693,1846,1977,5155,7414,2066,818,8437,6198,3558,5720,2244,11221,51719,207,25759,2065,27040,8074,5691,5156,8660,54756,2475,3480,389541,25780,28956,2251,3082,2260,5700,4254,3559,9365,27006,2243,408,54106,4233,1437,9048,5694,84078,8682,3265,2253,5528,5718,5707,3562,5605,6233	DLG4,IGF2,SPTBN2,PPM1A,EIF4G1,PSMA5,PSMB2,PDPK1,IL5RA,DUSP6,MAPK1,RASGEF1A,PSMA4,JAK2,PRKAB1,PSMC4,FGFR4,PIK3CB,RASA4,SHC1,RASGRF2,GRIN2B,EGFR,HBEGF,STRADB,BRAP,PRKAA2,FRS3,EREG,FGFR2,RRAGC,RASGRF1,GFRA3,PSME3,PSMF1,GRIN2A,PDGFRB,UBC,GFRA2,CALM3,SPRED2,PSMA1,PSMD9,PPP2R5A,YWHAB,NRG4,WDR83,FN1,FGF2,SPRED1,PSMC2,FGFR3,RASA1,PPP2R5B,SOS1,FGF19,PIK3C3,FGF5,DUSP7,RASAL2,DUSP8,FGF4,PTK2,RAP1A,MLST8,GRB2,GFRA1,MAP3K11,JAK3,RASA2,PPP2CB,PSMC3,PRKAA1,IL5,SPRED3,NF1,DUSP5,MARK3,STRADA,CSK,DUSP16,LAMTOR1,PPP2CA,FGF17,UBB,APBB1IP,EIF4B,PSMB9,CUL3,RET,PIK3R1,SRC,EEF2K,PDE3B,PSMD14,CAMK2B,PSMD8,PIK3R2,NEFL,IL2RB,CALM2,PSMA3,MAPK3,FRS2,RHEB,UBA52,PSMB10,FGF20,RASAL3,RRAGA,CNKSR1,PSMD7,RBX1,PAQR3,NRTN,DAB2IP,GRIN2D,GAB1,PSMD5,KIT,RPS6,FGG,CAB39L,PSMC6,NRG3,FGF3,GRIN2C,GDNF,AKAP9,ARRB2,BRAF,NCAM1,IQGAP1,LAMTOR3,STK11,SPTBN1,PRKAB2,PRKAG3,PPP2R1A,CAMK2A,SPTBN5,RAP1B,KRAS,JAK1,PTPRA,TSC2,PEBP1,EGF,SPTAN1,PHB1,CALM1,PSMA6,NRG2,FGF18,RAF1,LAMTOR5,MAP2K1,PSPN,PPP5C,CSF2RB,PSMB8,SPTBN4,DUSP1,SYNGAP1,ANGPT1,EIF4EBP1,PSMB7,FGF7,RRAGD,SPTB,NRAS,PSMB11,PRKAG1,FGF10,PSMB4,DUSP2,SEM1,ACTN2,PSME4,PSMD4,IGF1,PSMA8,RASGRP1,PSMD6,SHC3,FGF1,RPTOR,RASGRP4,PSMD2,PPP2R1B,PIK3R4,NRG1,PPP2R5C,PSMD11,ERBB2,THEM4,AKT1S1,TEK,BTC,IRS1,KSR2,TSC1,RANBP9,PDGFA,ITGB3,SPTA1,TRIB3,FYN,PSMB5,PRKAG2,CAMK2D,AKT2,GFRA4,FGF9,MIR5004,ITGA2B,PTPN11,PIK3CA,PPP2R5E,PSMD13,VWF,RAPGEF2,DUSP4,EIF4E,PDGFB,VCL,ERBB4,CAMK2G,RASAL1,RPS6KB1,IL2,PSME1,FGB,DUSP10,CAB39,AKT1,SHC2,ERBB3,LAT,FGF23,PSMB3,PDGFRA,IRS2,IL17RD,MTOR,IGF1R,LAMTOR4,RASGRP3,LAMTOR2,FGF6,HGF,FGFR1,PSMC1,KITLG,IL2RA,KL,FGF22,FGA,ARRB1,TLR9,MET,CSF2,ARTN,PSMB6,KBTBD7,PEA15,HRAS,FGF8,PPP2R5D,PSMD12,PSMD1,IL3,MAP2K2,RPS27A
R-HSA-2428928	IRS-related events triggered by IGF1R	0.0138528768764973	-4.27926235120431	298	274	0.0303298649546159	9034	10285	5921,5526,6654,9965,5289,2250,1849,2335,161742,2247,5701,2261,5682,5715,5525,7529,145957,84292,808,200734,2675,5159,7316,5923,64121,2676,10197,9491,2903,10817,5563,2069,2263,8315,1956,1839,55437,6464,5924,2904,5564,5704,2264,5291,10156,221002,5685,3717,5170,3568,1848,5594,1981,5686,5690,1742,3481,6712,5494,673,4684,8826,8649,6711,6794,5565,2905,2668,10142,409,2266,5706,81617,10718,2248,2906,2549,5711,3815,6194,4902,153090,64926,10670,10256,5713,9978,152559,5595,10818,6009,7311,5699,26281,805,5684,5296,4747,3560,816,5714,5295,29904,6714,10213,5140,5698,1975,54518,8452,5979,8822,5515,7314,4140,92335,1445,80824,55004,5516,5702,5562,3567,399473,4763,1847,9462,2249,1850,5747,2674,5906,64223,2885,4296,5922,3718,3667,283455,7248,10048,5154,3690,6708,84335,7010,685,5519,30849,5717,5527,3084,2064,117145,9861,53358,2246,57521,115727,5708,5710,3479,143471,10125,1844,7979,88,23198,2255,5692,6710,58528,122706,4893,5571,1978,5695,2252,1843,8831,284,5536,1439,5696,57731,10542,5604,5623,5687,8817,9542,5894,5037,7249,6709,1950,5245,801,5908,3845,3716,5786,53632,5518,815,51332,5707,3562,5605,6233,2253,5528,5718,3265,5694,84078,8682,54106,4233,1437,9048,408,2260,5700,4254,3559,9365,27006,2243,28956,25780,2251,3082,54756,2475,3480,389541,2065,8074,27040,5691,5156,8660,5720,2244,11221,51719,207,25759,1977,5155,7414,818,2066,8437,6198,3558,5290,5719,5529,1846,9693,7450,2254,64096,100847012,3674,5781,208,57761,2534,5693,817,51422	RASA1,PPP2R5B,SOS1,FGF19,PIK3C3,FGF5,DUSP7,FN1,SPRED1,FGF2,PSMC2,FGFR3,PSMA1,PSMD9,PPP2R5A,YWHAB,NRG4,WDR83,CALM3,SPRED2,GFRA2,PDGFRB,UBC,RASGRF1,RRAGC,GFRA3,PSME3,PSMF1,GRIN2A,FRS3,PRKAA2,EREG,FGFR2,BRAP,EGFR,HBEGF,STRADB,SHC1,RASGRF2,GRIN2B,PRKAB1,PSMC4,FGFR4,PIK3CB,RASA4,RASGEF1A,PSMA4,JAK2,PDPK1,IL5RA,DUSP6,MAPK1,EIF4G1,PSMA5,PSMB2,DLG4,IGF2,SPTBN2,PPM1A,BRAF,NCAM1,IQGAP1,LAMTOR3,SPTBN1,STK11,PRKAB2,GRIN2C,GDNF,AKAP9,ARRB2,FGG,PSMC6,CAB39L,NRG3,FGF3,GRIN2D,GAB1,PSMD5,KIT,RPS6,NRTN,DAB2IP,RASAL3,RRAGA,CNKSR1,PSMD7,RBX1,PAQR3,MAPK3,FRS2,RHEB,UBA52,PSMB10,FGF20,CALM2,PSMA3,PIK3R2,NEFL,IL2RB,CAMK2B,PSMD8,PIK3R1,EEF2K,SRC,PSMD14,PDE3B,PSMB9,EIF4B,APBB1IP,CUL3,RET,FGF17,PPP2CA,UBB,MARK3,STRADA,CSK,DUSP16,LAMTOR1,PPP2CB,PSMC3,PRKAA1,IL5,SPRED3,NF1,DUSP5,RASAL2,FGF4,DUSP8,PTK2,GFRA1,RAP1A,MLST8,GRB2,MAP3K11,RASA2,JAK3,IRS1,KSR2,TSC1,RANBP9,PDGFA,ITGB3,SPTA1,AKT1S1,TEK,BTC,PPP2R1B,PIK3R4,PSMD11,PPP2R5C,NRG1,ERBB2,THEM4,PSMD6,SHC3,FGF1,RPTOR,RASGRP4,PSMD2,PSMD4,IGF1,PSMA8,RASGRP1,DUSP2,SEM1,ACTN2,PSME4,FGF10,PSMB4,SPTB,RRAGD,PSMB11,NRAS,PRKAG1,EIF4EBP1,PSMB7,FGF7,DUSP1,SYNGAP1,ANGPT1,PPP5C,CSF2RB,PSMB8,SPTBN4,LAMTOR5,MAP2K1,PSPN,PSMA6,FGF18,NRG2,RAF1,PEBP1,TSC2,SPTAN1,EGF,PHB1,CALM1,RAP1B,KRAS,JAK1,PTPRA,PRKAG3,PPP2R1A,CAMK2A,SPTBN5,PSMD1,IL3,MAP2K2,RPS27A,FGF8,PPP2R5D,PSMD12,HRAS,PSMB6,KBTBD7,PEA15,TLR9,MET,CSF2,ARTN,ARRB1,FGFR1,PSMC1,KITLG,IL2RA,KL,FGF22,FGA,LAMTOR2,RASGRP3,FGF6,HGF,IL17RD,MTOR,IGF1R,LAMTOR4,ERBB3,FGF23,LAT,PSMB3,PDGFRA,IRS2,PSME1,FGB,DUSP10,CAB39,AKT1,SHC2,EIF4E,PDGFB,VCL,CAMK2G,ERBB4,RASAL1,RPS6KB1,IL2,PIK3CA,PSMD13,PPP2R5E,DUSP4,RAPGEF2,VWF,FGF9,GFRA4,MIR5004,ITGA2B,PTPN11,AKT2,TRIB3,FYN,PSMB5,CAMK2D,PRKAG2
R-HSA-1500931	Cell-Cell communication	0.0142725577767192	-4.24941662201921	133	125	0.0138366172238211	9034	10285	6300,26285,977,667,1630,5818,1004,7122,3987,25945,3909,10979,253559,6709,57453,1495,8935,1009,5291,1365,55243,5599,9069,5777,1366,5879,149461,1012,5584,4690,2318,1308,1008,137075,1015,5603,9073,29780,1001,961,88,7016,81607,1016,9863,4868,24146,50848,1003,5819,2185,100126326,999,55742,23607,23562,10207,283,56288,3728,1010,53842,7408,9071,54751,5747,2885,84612,84623,2534,1826,5010,140885,57863,5290,5817,4301,5829,3611,5781,55423,6714,1432,100422894,5295,3914,87,1002,84552,6251,5296,64398,81,1500,5600,3655,8976,89,1006,51208,3691,10686,1499,8440,64403,9423,23705,1005,1007,7305,9076,3918,9080,5339,1000,2533,5058,55679,6711,1013,1364,8826,3688,10326,49861	MAPK12,CLDN17,CD151,DST,DCC,NECTIN1,CDH6,CLDN5,LIMS1,NECTIN3,LAMA3,FERMT2,CADM2,SPTAN1,DSCAML1,CTNNA1,SKAP2,CDH11,PIK3CB,CLDN3,KIRREL1,MAPK8,CLDN12,PTPN6,CLDN7,RAC1,CLDN19,CDH13,PRKCI,NCK1,FLNC,COL17A1,CDH10,CLDN23,CDH17,MAPK13,CLDN8,PARVB,CDH3,CD47,ACTN2,TESK1,NECTIN4,CDH18,MAGI2,NPHS1,CLDN15,F11R,CDH5,NECTIN2,PTK2B,MIR936,CDH1,PARVA,CD2AP,CLDN14,PATJ,ANG,PARD3,JUP,CDH12,CLDN22,VASP,CLDN10,FBLIM1,PTK2,GRB2,PARD6B,KIRREL3,FYN,DSCAM,CLDN11,SIRPA,CADM3,PIK3CA,PVR,AFDN,PXN,ILK,PTPN11,SIRPG,SRC,MAPK14,MIR4260,PIK3R1,LAMB3,ACTN1,CDH4,PARD6G,RSU1,PIK3R2,PALS1,ACTN4,CTNND1,MAPK11,ITGA6,WASL,ACTN3,CDH8,CLDN18,ITGB4,CLDN16,CTNNB1,NCK2,CDH24,NTN1,CADM1,CDH7,CDH9,TYROBP,CLDN1,LAMC2,CLDN9,PLEC,CDH2,FYB1,PAK1,LIMS2,SPTBN1,CDH15,CLDN4,IQGAP1,ITGB1,SIRPB1,CLDN20
R-HSA-1280218	Adaptive Immune System	0.0147309757584889	-4.21780280776274	810	731	0.0809165375249059	9034	10285	51130,223082,7334,5695,8503,3904,27181,5879,23112,1385,8655,640,916,160,10273,933,11275,9542,567,11059,1075,84876,1950,23376,7249,10385,57542,79754,56253,3845,5908,11314,9666,26263,8925,685,84335,54620,6850,5717,3685,5909,2246,80176,143471,5710,996,23198,390594,6891,6456,5692,84261,89953,642,162,55585,941,1027,2932,1514,54778,972,2210,5155,7525,5529,11126,2254,55521,1493,3111,23194,1211,5693,5058,3702,26259,644076,55176,57823,5528,23608,80329,84961,51466,29127,79908,7099,2533,7318,1780,3683,7704,10333,100847079,65264,27006,6199,79837,57154,3082,79654,23308,10489,9903,55824,7087,64750,90025,6494,3133,23352,917,5293,10000,84937,7534,146330,222235,142678,7323,57690,8454,5686,7174,8773,5336,3802,2250,140459,3805,5701,8174,5966,945,253260,145957,8395,8945,27180,401036,997,808,164,1510,1062,9491,9820,2069,2214,6810,868,5714,3551,7325,974,64320,6714,10892,5295,53339,3932,1326,10112,84541,3135,5515,11027,4277,27252,5817,1445,285852,3107,9902,6885,118788,3127,56244,23304,5566,5706,4067,8519,81930,7337,7305,10818,83547,54926,79109,3120,7322,4790,940,7328,51191,8778,114836,5305,55615,5894,8817,5687,153579,3383,26270,54210,5518,64682,55182,51665,6468,1147,5519,22954,9976,192669,4615,696,942,57630,29851,3635,1759,29927,8660,51433,374383,6049,161,3385,8074,2065,926,126433,5720,135250,25831,23239,51343,10484,89122,10411,8915,55658,89858,29945,3106,4012,5567,79865,5707,151888,7336,3265,93611,718,90933,192670,51164,5700,3831,136371,25780,2251,64718,146722,114132,146894,1956,202658,83737,5704,10427,26224,27327,197131,3708,84708,5170,54850,11127,64410,3117,11258,84676,3709,2247,10768,29126,92591,7529,11065,5071,1173,5525,1781,4345,9398,5970,30835,6502,6478,140739,91694,5159,6923,10666,55008,10197,2263,998,122769,10540,3799,5592,10213,1520,1026,56992,5698,57674,4193,867,3689,5930,3812,26272,975,9817,4008,10393,5788,3688,6890,10718,51444,26234,10437,55740,3815,5711,140735,4360,842,4794,4343,958,3798,1175,10616,5699,1535,5595,25793,1639,11024,5684,7879,9604,991,5696,26232,4734,84643,26046,6500,26223,6786,7097,285643,8673,26190,115290,11069,22888,100131439,64167,3667,51676,3112,117145,3384,2064,5527,84085,10235,9861,9616,920,140691,3796,92369,10477,7157,7979,3643,2931,22920,51752,911,4893,122706,127544,63893,3113,8651,55958,10533,2475,90678,1213,5156,8697,5691,120425,8139,207,10225,80196,6892,80028,6614,114609,3309,100507436,929,1525,5719,23108,5781,9554,11004,25897,63891,23327,79791,131405,5718,140461,26052,200845,79876,84078,375,84231,23396,946,127247,10384,51529,10293,4254,2260,100616453,80228,10120,7321,5777,5795,84516,9437,114907,3093,3710,140458,2264,5291,5685,5594,26267,5335,9690,5641,3108,1174,11118,6654,9493,259197,51348,8396,23291,9402,4792,5588,9020,10802,5682,100616150,5819,23014,3109,114088,8065,9871,23480,51320,26191,3695,11006,4793,29121,5296,55236,3136,2309,10425,50852,89910,9354,144699,9632,7326,10121,7314,1519,51619,10871,3821,23035,915,3630,51434,5702,5516,2885,100528032,342510,6725,55070,118424,255488,55175,3693,947,51465,2549,130340,2308,89790,9978,131450,811,909,29760,6737,154881,7220,9341,84861,84433,2252,3832,27071,10859,9436,26249,3820,10193,1512,9246,801,919,25898,7412,11119,5728,7189,5154,51128,143279,1515,3084,117157,5708,8722,79465,999,55819,5568,3676,10125,653361,3903,1778,3123,2255,6047,3835,9520,4688,23295,3164,912,27040,7327,57531,5062,8924,2066,3386,221687,26153,5290,8916,3902,3105,7332,10671,208,3122,2534,7320,57761,23643,9039,2209,147700,6233,80380,2253,22914,6396,9870,7335,5694,148581,4233,3937,910,4689,1513,9021,9365,50489,26523,10219,51143,57520,5579,10324,55294,1839,4690,26235,23118,201456,6464,2213,7409,8907,7428,930,163,5690,1509,51088,11120,7096,6712,10952,3134,9965,5526,4591,8870,2261,6402,140460,7408,142685,7324,8453,3811,5715,9320,283807,51666,5493,285231,1508,6921,821,55284,1783,7316,92912,3797,27036,114876,10053,8394,27161,7498,3804,64837,8452,142686,3118,26268,8822,55905,29116,64223,5906,8767,2249,22872,89890,973,899,3119,2248,9867,1785,154214,9730,150726,5713,7535,26281,7311,948,3824,805,6477,124599,26091	ASB3,ZNRF2,UBE2N,PSMB7,PIK3R3,LAIR2,SIGLEC8,RAC1,TNRC6B,CREB1,DYNLL1,BLK,CD3E,AP2A1,STUB1,CD22,KLHL2,NRG2,B2M,WWP1,CTSC,ORAI1,EGF,UFL1,TSC2,BTN2A2,KLHL42,ASB13,CRTAM,KRAS,RAP1B,CD300A,DZIP3,FBXO22,HERC1,BTC,AKT1S1,FBXL19,SYK,PSMD11,ITGAV,RAP1GAP,FGF1,SPSB1,PSMA8,PSMD4,CDC27,PSME4,KBTBD13,TAP2,SH3GL2,PSMB4,FBXW9,KLC4,BLMH,AP1B1,UBE2Q1,CD80,CDKN1B,GSK3B,CTSL,RNF111,CD74,FCGR1BP,PDGFB,YES1,PPP2R5E,CD160,FGF9,TRIM36,CTLA4,HLA-DOA,FBXL7,CLTA,PSMB5,PAK1,ITK,FBXW8,GLYCAM1,SEC61A2,SLAMF7,PPP2R5D,MKRN1,ULBP1,FBXL20,EVL,RACGAP1,BTNL8,TLR4,FYB1,UBA7,DYNC1I1,ITGAL,ZBTB16,TLR6,MIR5193,UBE2Z,FGF22,RPS6KB2,PIP4K2C,SMURF1,HGF,HECTD3,ICOSLG,LRRC41,KLHL21,PAG1,ICAM5,SMURF2,UBE3D,SIPA1,HLA-E,UBR4,CD3G,PIK3CD,AKT3,ZNRF1,YWHAZ,FBXL16,FBXL13,MIB2,UBE2D3,TNRC6C,CUL1,PSMA5,TPP2,SNAP23,PLCG2,KIR2DL1,FGF5,ASB6,KIR2DL4,PSMC2,MADCAM1,REL,CD33,RICTOR,NRG4,PIP5K1B,BTRC,SIGLEC9,ASB18,CDC34,CALM3,AP1G1,CTSE,CENPE,PSMF1,CUL7,EREG,FCGR3A,STX4,CBLB,PSMD8,IKBKB,UBE2E2,CD79B,RNF25,SRC,MALT1,PIK3R1,BTBD1,LCK,MAP3K8,KIF20A,KBTBD8,HLA-G,PPP2CA,LILRA2,MICB,KLHL20,PVR,CSK,TREML4,HLA-C,MRC2,MAP3K7,PIK3AP1,HLA-DRB5,BTNL2,UBR2,PRKACA,PSMC6,LYN,IFITM1,KIF18A,UBE3A,TYROBP,FRS2,RILP,UBE2R2,MAPKAP1,HLA-DQB2,UBE2D2,NFKB1,CD28,UBE2H,HERC5,SIGLEC5,SLAMF6,PIP4K2A,PRR5,RAF1,FGF18,PSMA6,BTNL9,ICAM1,FBXO6,TREM1,PPP2R1A,ANAPC1,RNF220,ASB1,FBXW4,CHUK,PPP2R1B,TRIM32,CLEC2B,AGO3,MYD88,BTN1A1,CD86,SH3RF1,ICOS,INPP5D,DNM1,SEC61A1,IRS2,ANAPC5,NCR3LG1,RNF6,AP2A2,ICAM3,FGF23,ERBB3,CD8B,FBXO27,PSME1,RAET1E,HECTD1,PHLPP1,FZR1,SEC23A,TRIM4,RAPGEF3,BCL10,RNF126,SIGLEC12,ANAPC4,HLA-B,LNPEP,PRKACB,TREML2,PSMD1,BTLA,UBE2V2,HRAS,FBXO44,C3,TRIM41,AGO4,DCTN4,PSMC1,KLC1,ASB10,RASGRP3,FGF6,UNKL,CD300LF,SIGLEC11,CD300LG,EGFR,TRIM39-RPP21,ITCH,PSMC4,SEC24B,FBXL3,TNRC6A,UBR1,ITPR1,LNX1,PDPK1,FBXL12,KIF3A,KLHL25,HLA-DQA1,DCTN3,TRIM63,ITPR2,FGF2,AHCYL1,CD274,ASB16,YWHAB,UBE2C,PRKN,AP2M1,PPP2R5A,DYNC1I2,CD200,CD101,RELA,CD209,SKP2,SIAH2,UBE2F,LONRF1,PDGFRB,ELOB,CD226,HERC6,PSME3,FGFR2,CDC42,LRR1,DCTN2,KIF5B,PRKG1,PSMD14,CTSS,CDKN1A,KIF15,PSMB9,RNF213,MDM2,CBL,ITGB2,RBBP6,KIR3DL2,FBXO4,CD81,KEAP1,LMO7,ANAPC10,PTPRC,ITGB1,TAP1,NRG3,RNF138,FBXL5,IFI30,ENAH,KIT,PSMD5,DYNLL2,MRC1,CASP9,NFKBIE,MOV10,CD40,KIF5A,AP2S1,RBCK1,PSMB10,CYBA,MAPK3,FBXO7,DCTN1,LILRA1,PSMA3,RAB7A,RNF14,CDC20,PSMB8,FBXO2,NEDD4,KIF2B,LTN1,SKP1,FBXL21P,STIM1,TLR2,KIF4B,VAMP8,FBXW2,FBXO17,RAPGEF4,UBOX5,CD300LD,ERAP2,IRS1,ASB2,HLA-DOB,THEM4,ICAM2,ERBB2,PPP2R5C,FBXO30,RASGRP2,PSMD6,RNF7,CD4,TRIM69,KIF2A,SPSB4,UBE2E3,TP53,SEM1,INSR,GSK3A,KIFAP3,ERAP1,CD1C,NRAS,PSMB11,RNF19B,UBE2O,HLA-DPA1,SOCS1,KLHL9,ATG7,MTOR,LRSAM1,CLTC,PDGFRA,CDC23,PSMB3,JAML,GAN,AKT1,CD96,RNF34,TAPBP,FBXL18,SIGLEC1,TIRAP,HSPA5,MICA,CD14,CXADR,PSMD13,RAP1GAP2,PTPN11,SEC22B,KIF2C,RNF19A,RNF123,NEDD4L,FBXO31,TRIM71,PSMD12,ASB8,DNM3,KCTD6,UBA5,KBTBD7,ARF1,TRAF7,PIP5K1C,SIGLEC6,ASB17,BTN3A3,ANAPC11,TRAIP,KITLG,FGFR1,MIR4687,ORAI2,ACTR1B,UBE2D1,PTPN6,PTPRJ,DCTN5,NCR1,FBXO32,UBE2K,ITPR3,ASB5,FGFR4,PIK3CB,PSMA4,MAPK1,FBXO10,PLCG1,UBE3C,LGMN,HLA-DMA,AP1S1,BTN3A2,SOS1,KIF23,NCR3,KLRF1,PIP4K2B,FBXW11,GRAP2,NFKBIA,PRKCQ,MAP3K14,SEC24A,PSMA1,MIR4720,NECTIN2,FBXO21,HLA-DMB,TRIM9,CUL5,SEC24D,SEC61G,MEX3C,PTPN22,ITGB7,LILRB4,NFKBIB,CLEC2D,PIK3R2,UBA6,HLA-H,FOXO3,ARIH2,TRAT1,UBE3B,UBE4A,FBXL14,SEC24C,UBE2G1,ACTR1A,UBB,CTSO,UBE2D4,CD300C,KLRC1,PHLPP2,CD3D,INS,ANAPC7,PSMC3,PPP2CB,GRB2,KLRC4-KLRK1,CD300E,SRMS,DET1,UBE2J2,RNF144B,KLHL11,ITGB5,CD34,UBE2J1,GAB1,AP1S3,FOXO1,SIGLEC10,RBX1,CD200R1,CALR,CD1A,BLNK,TRIM21,KCTD7,TRPC1,VAMP3,KLHL22,CARD11,FGF7,KIF11,DAPP1,LILRB1,NCR2,KLHL3,KLRB1,RNF41,CTSH,UBE2L6,CALM1,CD247,RCHY1,VCAM1,BTN3A1,PTEN,TRAF6,PDGFA,SAR1B,HECTD2,CTSV,NRG1,SH2D1B,PSMD2,CTSF,ULBP3,CDH1,RNF130,PRKACG,ITGA4,RASGRP1,NCF1,LAIR1,DYNC1H1,HLA-DRB1,FGF10,RNF4,KIF22,NPEPPS,NCF2,MGRN1,NR4A1,CD1D,LAT,UBE2G2,HACE1,PAK2,HERC2,ERBB4,ICAM4,RNF182,KIF26A,PIK3CA,HERC3,LAG3,HLA-A,UBE2L3,DCTN6,AKT2,HLA-DRA,FYN,UBE2B,TRIB3,LY96,UBA3,FCGR1A,KLC3,RPS27A,PDCD1LG2,FGF8,KLRK1,SEC13,AREL1,UBE2V1,PSMB6,UBE2U,MET,LCP2,CD1B,NCF4,CTSK,SOCS3,KL,CD207,AGO1,KLRG1,DYNC1LI1,HECW2,PRKCB,KLHL41,FBXW7,HBEGF,NCK1,FBXL4,TAB2,FBXO15,SHC1,FCGR2B,VAV1,AP1M1,VHL,CD19,AP2B1,PSMB2,CTSD,KLHL5,BTN2A1,TLR1,SPTBN2,SEC61B,HLA-F,FGF19,PPP2R5B,TRIM37,IER3,FGFR3,SELL,ASB7,VASP,ASB15,UBE2E1,CUL2,KIR3DL1,PSMD9,TRIP12,FBXL22,ASB4,PPL,FBXW12,CTSB,ELOC,CANX,UBE2W,DYNC1LI2,UBC,UBE2Q2,KIF3C,SIGLEC7,OSBPL1A,AP1M2,PIP5K1A,AGO2,XDH,KIR2DL3,KLC2,CUL3,ASB14,HLA-DQA2,FBXO9,FGF17,RNF114,MYLIP,MLST8,RAP1A,RIPK2,FGF4,SEC31A,KBTBD6,CD79A,CCNF,HLA-DQB1,FGF3,PJA2,DNM2,RNF217,DCAF1,FBXO41,PSMD7,ZAP70,FGF20,UBA52,CD36,KLRD1,CALM2,SIAH1,CD300LB,HERC4
R-HSA-4570464	SUMOylation of RNA binding proteins	0.0149718317976511	-4.20158472346398	48	47	0.00520256807615674	9034	10285	8086,9631,81929,129401,7175,4928,407043,80012,4927,3183,6613,51602,648,8021,9883,7329,6045,79902,100500853,1911,84733,57122,55746,23636,10762,3190,348995,9688,55706,11097,57332,9818,1912,79023,23225,9972,53371,7703,8535,5903,23165,100101267,6015,7341,23279,23511,22955	AAAS,NUP155,SEH1L,NUP35,TPR,NUP98,MIR7-1,PHC3,NUP88,HNRNPC,SUMO2,NOP58,BMI1,NUP214,POM121,UBE2I,RNF2,NUP85,MIR3605,PHC1,CBX2,NUP107,NUP133,NUP62,NUP50,HNRNPK,NUP43,NUP93,NDC1,NUP42,CBX8,NUP58,PHC2,NUP37,NUP210,NUP153,NUP54,PCGF2,CBX4,RANBP2,NUP205,POM121C,RING1,SUMO1,NUP160,NUP188,SCMH1
R-HSA-418597	G alpha (z) signalling events	0.0149718317976511	-4.20158472346398	48	47	0.00520256807615674	9034	10285	151,2783,114,2778,112,5580,150,10287,5578,406974,5583,2791,2771,2770,2790,2786,2788,2793,2773,5581,8601,115,2787,196883,2781,5588,113,2782,51764,5582,108,353299,10681,59345,111,2792,5999,2784,54331,109,107,5579,55970,346562,152,94235,26575	ADRA2B,GNB2,ADCY8,GNAS,ADCY6,PRKCD,ADRA2A,RGS19,PRKCA,MIR197,PRKCH,GNG11,GNAI2,GNAI1,GNG10,GNG4,GNG7,GNGT2,GNAI3,PRKCE,RGS20,ADCY9,GNG5,ADCY4,GNAZ,PRKCQ,ADCY7,GNB1,GNG13,PRKCG,ADCY2,RGSL1,GNB5,GNB4,ADCY5,GNGT1,RGS4,GNB3,GNG2,ADCY3,ADCY1,PRKCB,GNG12,GNAT3,ADRA2C,GNG8,RGS17
R-HSA-112040	G-protein mediated events	0.0149718317976511	-4.20158472346398	48	47	0.00520256807615674	9034	10285	10768,5573,2781,196883,3709,115,23236,5567,5568,808,2773,5332,2770,5566,5137,2771,406974,5578,5576,5580,112,5136,114,805,5575,5577,2780,5321,1385,346562,814,109,107,156,5330,3710,2779,111,5594,801,3708,108,5331,5582,5153,2774,113	AHCYL1,PRKAR1A,GNAZ,ADCY4,ITPR2,ADCY9,PLCB1,PRKACB,PRKACG,CALM3,GNAI3,PLCB4,GNAI1,PRKACA,PDE1C,GNAI2,MIR197,PRKCA,PRKAR2A,PRKCD,ADCY6,PDE1A,ADCY8,CALM2,PRKAR1B,PRKAR2B,GNAT2,PLA2G4A,CREB1,GNAT3,CAMK4,ADCY3,ADCY1,GRK2,PLCB2,ITPR3,GNAT1,ADCY5,MAPK1,CALM1,ITPR1,ADCY2,PLCB3,PRKCG,PDE1B,GNAL,ADCY7
R-HSA-1430728	Metabolism	0.0150683978625436	-4.19515558503162	2158	1925	0.213083905246845	9034	10285	3747,64419,6233,6812,6169,9453,3248,777,55349,1634,4736,1352,1384,79717,7069,6799,9956,113278,51171,5443,241,2720,8703,4338,270,29920,123099,53905,9362,60678,54577,1463,9572,1738,114880,3636,23324,4969,9429,283927,6168,10135,80821,96764,54658,128486,6582,2534,6517,57761,6554,336,55500,167127,279,1645,435,6207,3036,151056,6154,6861,5445,3099,7372,353,10894,10577,23636,3704,3992,635,26007,216,4708,55526,166929,6235,9388,2271,57407,7054,4709,158,6604,622,9972,9394,140801,4141,5232,801,773,57546,5728,200879,341392,1376,131870,3098,6470,6521,27306,64180,8802,79902,79001,83440,1109,9412,79644,2788,5950,4495,3145,285521,375790,29923,2740,776,341,6539,2592,8050,4521,7389,32,1584,6713,6341,6224,7311,79071,23743,8760,337,66002,6538,7172,3613,26291,84836,6382,9562,883,2,213,1717,3945,29078,5501,4831,23446,2052,5294,5211,6715,81034,5289,646480,765,217,29095,57605,6138,4715,51599,10908,892,5644,54579,4493,266722,114876,2992,200895,83401,316,93058,4056,27242,790,5346,10166,64600,51573,5464,100861540,107,6139,5836,1152,6579,384,5007,1576,759,9818,163,22949,5288,3615,1490,55347,5901,2098,84532,23590,669,9962,57834,90390,5690,142910,4597,55289,2746,5096,377677,113189,284486,54947,348995,64711,619189,27010,23396,6217,51196,115677,54981,6718,3161,6210,2531,226,27124,6476,344967,80308,9443,8871,2783,54,119391,6135,4718,2171,1213,590,79143,259307,4719,3067,50486,55512,11046,3292,4907,9663,1103,55902,51065,1071,387787,1629,54477,138199,51228,6241,1593,23464,11285,2821,1716,33,57017,9391,6133,81616,27165,2806,55065,27349,10955,4144,54490,29841,56994,10762,3949,5471,29968,240,4363,2879,26251,128,6144,122706,1503,762,339896,23530,9583,4802,51071,5837,4507,7385,1577,1595,23479,2131,6175,3081,5743,6484,56261,271,10082,7957,4190,55331,5696,9227,4499,373156,4864,2274,29914,189,11069,3948,683,5805,2953,54480,8310,10,51241,55825,2817,5867,2331,81693,64077,125981,9926,1337,5947,4722,3155,2791,1160,9600,113612,55454,23521,4705,5860,686,6390,539,27284,80306,9957,154807,64802,2328,22978,35,6296,7350,29796,8604,144193,2642,1581,2618,7357,84699,150379,7314,55270,55706,123745,54675,1468,144195,56895,1733,3630,2548,6646,22908,5702,4524,1119,57019,5320,285440,51706,494143,64801,2949,8396,5162,5332,6206,3037,116255,8611,10327,5682,3030,2180,10131,93010,6124,389434,31,10675,346606,137964,64757,788,80270,6307,64174,1735,25796,3420,39,11164,79411,23761,23225,114881,2980,5214,5723,5291,23279,9651,23533,23305,5257,223,2987,2948,6770,166785,25873,1118,84875,5226,1208,51129,6916,8647,58478,6165,5641,114883,4700,8398,125,60386,6142,65220,201562,127281,4048,27068,229,161823,26330,9630,949,9380,6208,11000,2771,79966,3157,570,27329,8463,3033,9348,85414,4707,9971,83394,55191,95,9896,9955,9349,440387,80736,161,53371,4862,337876,3635,123688,4942,246,133121,1373,5720,8513,3991,6482,6181,7371,2946,10484,79152,132,51422,79178,6209,80230,10411,51601,5446,9953,6581,1646,6888,8706,11041,11112,8566,11330,3712,30849,63827,22901,160287,9420,81544,400569,4967,151531,8086,8309,118672,80168,51181,114,8034,100137049,2232,85007,54996,291,2583,113451,84987,2350,50506,2326,516,211,1737,6160,10165,132158,25874,9677,23259,2731,4337,8424,10681,57110,338328,204,79873,58472,1351,6518,875,3101,64210,11097,154141,3294,11163,3633,6167,2729,326625,1565,3425,255189,9060,231,8826,6130,513,5711,79887,57818,6122,183,7005,1175,262,27132,25830,5684,8659,8692,112950,5699,8976,5164,2033,6137,5740,771,152,2876,80724,8435,55301,5698,10062,23165,9791,11224,51365,247,30814,128240,9331,9619,5125,1573,54905,2950,55908,10005,5287,593,51302,5833,2262,10768,2712,10975,4724,2787,57678,23171,10599,6716,59338,1719,83990,7003,1173,200916,37,6319,1544,53343,112,4716,60490,445,6820,9440,92579,100616211,378884,135152,137682,6342,11145,221264,5704,4522,3326,2346,51085,80765,25961,80221,9489,5261,80772,8801,1718,51166,517,2101,5528,25902,10331,549,100,51293,221823,5095,2745,7084,4199,51686,4490,6136,29785,2678,2132,79837,178,6576,4023,126328,11261,1579,133522,6152,124,956,4801,221,6999,7923,23175,51091,2877,5783,210,5243,56953,2679,26275,3988,5286,169355,1056,79023,5693,55361,347734,606495,26229,157739,10606,55627,9615,54511,115,4710,25816,23632,57412,377,2805,51477,219,10965,10400,2786,9446,4598,259230,23198,4717,3069,3291,349565,441024,2639,117283,22874,29958,145482,276,10001,84725,64240,1632,2172,2638,83549,9255,8029,5695,54331,51,109,51504,8503,7386,56922,83930,874,55788,160,205,125061,6176,3162,26063,29940,4552,3320,23344,51144,94101,6566,10632,133688,3745,121278,3038,957,7364,132789,9,5587,4706,27233,9334,79944,51151,768,406,3156,6309,79602,160428,5223,5714,34,23539,2940,54956,10434,784,10226,51727,56603,27430,239,10720,8648,3039,58488,8612,56898,5331,1040,84618,2194,165679,23563,5549,6515,2947,5701,10560,5948,6230,6205,116285,319,55066,498,5447,5868,8395,2641,1582,4846,3972,644,130367,10678,29956,57515,10499,3837,3283,8560,5019,5264,9491,253430,197322,10162,126410,6513,4166,5660,23511,3638,2327,9123,65977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3054,27231,5706,4548,56624,81894,60495,191,4060,126969,9439,43,6580,204219,3614,7298,2683,28976,146850,5034,79048,10087,4726,248,51447,427,1583,5424,1350,7252,6223,111,7299,51121,5295,2730,91703,5515,6161,6817,22876,4258,4329,4714,56267,3767,64428,84869,808,10941,79888,383,2770,8534,10891,11010,1024,9631,8613,5045,10855,56894,389396,84245,7276,4948,8824,79603,4489,4494,8720,29881,374291,51520,142827,126792,7804,518,55576,27232,3990,64241,150763,26027,5293,4018,59345,131669,6667,9653,1585,25942,5166,5336,6202,5686,55090	KCNC2,MTMR14,RPS27A,STXBP1,RPL38,GGPS1,HPGD,CACNA1E,CHDH,DCN,RPL10A,COX10,CRAT,PPCS,THRSP,SULT1A2,HS3ST2,SLC52A3,HSD17B14,POMC,ALOX5AP,GLB1,B4GALT3,MOCS2,AMPD1,PYCR2,DEGS2,DUOX1,CPNE6,EEFSEC,UGT1A7,NCAN,NR1D1,DLD,OSBPL6,INPPL1,MAN2B2,OGN,ABCG2,NUDT7,RPL37A,NAMPT,DDHD1,TGS1,UGT1A1,FITM2,SLC22A2,FYN,SLC2A4,TRIB3,SLC10A1,APOA2,ETNK1,UGT3A2,AMY2A,AKR1C1,ASL,RPS13,HAS1,PLB1,RPL26,SYT5,PON2,HK2,UMPS,APRT,LYVE1,NPC2,NUP62,ITPA,FADS1,BHMT,TKFC,ALDH1A1,NDUFB2,DHTKD1,SGMS2,RPS29,LIPG,FH,NMRAL1,TH,NDUFB3,ADSL,SMARCD3,BDH1,NUP153,HS6ST1,RPL10L,MARS1,PGK2,CALM1,CACNA1A,PDP2,PTEN,LIPH,ACSM4,CPT2,NUDT16,HK1,SHMT1,SLC4A1,HPGDS,DPEP3,SUCLG1,NUP85,VKORC1,ADPGK,AKR1C4,MED21,SRD5A3,GNG7,RBP4,MT1G,HMBS,COX18,AGRN,HILPDA,GLP1R,CACNA1D,APOC1,SLC6A12,GALT,PDHX,NUDT1,UROD,ACACB,CYP11B1,SQLE,SCO1,RPS20,UBA52,ELOVL6,BHMT2,CDS2,APOA4,CYP4F12,SLC6A11,TPMT,IMPA2,FGF21,ABHD14B,SDC1,MINPP1,KYAT1,A2M,ALB,DHCR7,LDHB,NDUFAF4,PPP1CC,NME2,SLC44A1,EPHX1,PIK3CG,PFKL,SRD5A1,SLC25A32,PIK3C3,FABP9,CA6,ALDH2,ORMDL2,PITPNM2,RPL15,NDUFB9,LSR,PNPLA6,CCNC,PRSS1,UGT1A5,MT1E,HS6ST3,OSBPL1A,GYG1,DHFR2,ELOVL3,AOX1,COQ10A,LTC4S,TNFRSF21,CAD,PLIN1,SLC25A15,PLA2G2F,GDE1,PPA1,CYP3A7-CYP3A51P,ADCY1,RPL17,PYGL,CKB,SLCO1A2,ARG2,OSBP,CYP3A4,CA1,NUP58,AP2B1,PTGR1,PIK3C2G,IMPDH2,CCN2,ABHD10,RAN,ESD,ACSS1,PDSS1,BPGM,SLC23A2,CYP4F11,MED30,PSMB2,LIPJ,MVD,ACOXL,GLUD1,PCCB,CA13,CHST14,THEM5,LPCAT2,NUP43,HS3ST6,SERINC4,TPK1,PIP5K1C,RPS16,PLCE1,NOSTRIN,NMRK1,AKR1D1,HMMR,RPS15A,KDSR,ALDOA,INPP5J,SI,LOC344967,FLAD1,MED7,SYNJ2,GNB2,ACP5,GSTO2,RPL11,NDUFC2,FABP5,CLTC,BCHE,MBOAT7,IL4I1,NDUFS1,HDC,G0S2,SMPD3,SLC35D2,HSD17B1,NT5E,LPIN2,CHAT,ACSS2,RPS27L,CETP,LIPT2,DBT,PLEKHA5,CARNMT1,GLTP,RRM2,CYP27A1,GCAT,B4GALT7,GPI,DGUOK,ACADL,COQ9,CIAO1,RPL9,ACSBG2,GLS2,GOT2,SLC52A1,MCAT,SERINC3,MAT2A,UGT2B28,GRHL1,CHPT1,NUP50,LDLR,PPAT,PSAT1,ALOX5,ABCC1,GPX4,KCNG2,ADH5,RPL21,PSMB11,CTPS1,CA4,GADL1,NNT,ENTPD4,NFYC,DERA,PYGM,MTAP,UQCRC2,CYP3A5,CYP51A1,ISCU,EXT1,RPLP0,HGD,PTGS2,ST3GAL4,GPCPD1,AMPD2,GPC6,EPM2A,MDH1,ACER3,PSMB8,LRAT,MT1M,GSTK1,NPC1,FHL2,UBIAD1,AGXT,RAPGEF4,LDHC,BST1,PTS,GSTT2,CHPF2,ACOX3,NAT2,COX16,PECR,GPC1,RAB4A,FMOD,AMN,LHPP,ACER1,LPGAT1,COX6A1,RBP1,NDUFS3,HMGCL,GNG11,CKMT2,PITPNM1,CYP2U1,CSGALNACT2,RPL13A,NDUFA10,QDPR,BTD,SDHB,ATP5PO,SULT1B1,MED28,HS3ST1,VKORC1L1,NMNAT1,FMO3,NT5C2,ACADS,ACSM3,UCP1,UQCR10,SLC25A12,AMDHD1,GCGR,CYP7A1,GART,UGCG,CREB3L3,PNPLA5,UBB,NUDT15,NDC1,PLA2G4E,CRLS1,SLC25A10,SLC2A14,AGPAT4,DIO1,INS,GAA,SOAT1,SACM1L,PSMC3,MTHFR,CHKA,CIAPIN1,PLA2G2A,CYP4V2,CYB5R1,CHAC2,ARV1,GSTM5,PIP4K2B,PDHB,PLCB4,RPS12,HAS2,MOGAT1,PLPP1,AKR1A1,PSMA1,HADHA,ACSL1,TRAP1,B3GNT7,RPL4,IYD,ACACA,CSPG5,MOGAT3,GPAT4,MTARC1,SLC25A20,HSD3B7,MSMO1,DPEP2,DIO3,PGLS,IDH3B,ACAT2,NUDT5,GLB1L,PISD,NUP210,OSBPL7,GUCA2A,PFKP,PSPH,PIK3CB,NUP160,PLCH2,PIK3R5,ACSL6,PHKB,ALDH9A1,GUK1,GSTM4,STAR,MMAA,RPL36,CHIT1,PARP10,PGD,CLPS,ANGPTL4,TBXAS1,ABCB11,ENOPH1,RPL35A,LGMN,OSBPL9,NDUFA6,PLA2G6,ADH1B,SLC25A19,RPL18A,NADK,HACD2,PRXL2B,LTA4H,PPA2,ALDOB,ADAL,GAPDHS,GNA14,SCARB1,GRHPR,RPS14,SLC27A3,GNAI2,SCD5,HMGCS1,BAAT,ANGPTL3,TEAD2,HADH,NDST3,SLC45A3,NDUFB1,NR1H4,PITPNM3,NADSYN1,ACY1,FIG4,HS3ST3A1,RPL23,CTRB2,SLC44A4,AP2A2,NUP54,NPAS2,CHSY3,INPP5D,HYKK,OAT,ALOX15,ENPP6,CPS1,PSME1,LIPF,LIPE,ST3GAL1,RPLP2,UCK2,GSTM2,SEC23A,FA2H,ADK,PRKAG2,THTPA,RPS15,RUFY1,RAPGEF3,LIPT1,PON3,HS3ST3B1,SLC22A3,AKR1C2,TALDO1,B3GALNT1,B4GAT1,HIBADH,PDXK,CTRC,IVD,PIK3R4,BCAN,ARSG,LDHAL6A,CYP7B1,GDPD5,MED11,OGDH,UPP2,AAAS,ACOX2,PSTK,MOGAT2,DCXR,ADCY8,SLC25A16,PLA2G4B,FDXR,PHYKPL,MTARC2,SLC25A4,B4GALNT1,AZIN2,COX14,FOLR2,DUOX2,FMO1,ATP5MC1,ALAS1,DLAT,RPL31,SLC25A13,GLYCTK,MPC2,PPIP5K1,DDHD2,GLDC,MOCS1,BBOX1,GNB5,PLAAT1,GPIHBP1,AK2,NUDT18,SQOR,COX8A,SLC2A5,CBS,HK3,MMS19,NUP42,MBOAT1,HSD17B2,NUDT4,INPP5B,RPL37,GCLC,MMAB,CYP2D6,IDUA,PLA2G4F,PAPSS2,AKR1B1,IQGAP1,RPL7A,ATP5F1D,PSMD5,PLBD1,G6PC2,RPL3,AGT,TEAD3,AP2S1,AMD1,CPNE7,SULT4A1,PSMA3,ALDH4A1,HYAL2,MED8,PSMB10,WASL,PDK2,EP300,RPL13,PTGIS,CA12,ADRA2C,GPX1,ACAD10,SOAT2,OLAH,PSMB9,NR1H3,NUP205,PTDSS1,RPL35,PLA1A,ALOX15B,PLA2G2E,NAXE,B4GALT6,ABCG1,PCSK5,CYP2J2,CYP2W1,GSTP1,ANGPTL8,ACOT8,PIK3C2B,BCKDHA,CYP39A1,PCYT2,GPC5,AHCYL1,GK2,UQCR11,NDUFS4,GNG5,GPAM,GPD1L,SLCO1B1,SRD5A2,PLEKHA1,DHFR,BRIP1,TEAD1,AP2M1,RPL22L1,ACADVL,SCD,CYP1A2,NUDT9,ADCY6,NDUFB10,PPCDC,ASS1,SULT2B1,MED17,G6PC3,MIR4709,NHLRC1,B3GAT2,NDUFAF6,SCP2,PLAAT3,AK9,PSMC4,MTHFD1,HSP90AB1,FOLH1,MLXIPL,STARD5,NUDT13,ACSF2,PGS1,PHKG2,CPTP,SUCLG2,DHCR24,AADAT,ATP5MC2,ESRRA,PPP2R5D,MTHFD1L,B3GNT3,AUH,ADA,CD320,PRPS1L1,PCCA,GLRX,TK2,ME1,OAZ3,MT1B,RPL12,CYP2S1,GGT1,EXT2,PIP4K2C,AGL,SLC25A1,LPL,NDUFA11,CHP1,CYP4A11,PPARGC1B,RPL24,ADH1A,ENTPD3,NFYB,ALDH3B1,TDO2,HSD17B8,LPIN1,SEPSECS,GPX2,PTPN13,ALAD,ABCB1,NT5M,GGT3P,HIBCH,LIPA,PIK3C2A,IDO2,CEL,NUP37,PSMB5,PI4K2A,SLC35B2,CYB5RL,B3GAT3,TDH,PAICS,SMPD4,GDA,HMGCLL1,ADCY9,NDUFB4,TNFAIP8,CA14,AS3MT,ARF3,GOT1,ISYNA1,ALDH1B1,ACOT2,PEMT,GNG4,GSTO1,MVK,SGMS1,PSME4,NDUFC1,HDLBP,HSD11B2,NMNAT3,MTHFD2L,GCDH,IP6K3,PLEKHA6,DMGDH,PTGR2,AMY1A,MED6,PLEKHA8,ABCG5,ECI1,FABP6,GC,UCK1,AIMP1,CUBN,PSMB7,GNG2,ACOX1,ADCY3,TRMT112,PIK3R3,UQCRFS1,MCCC1,STARD3NL,CBR3,LMBRD1,AP2A1,AK4,AFMID,RPLP1,HMOX1,DECR2,DSE,MTRR,HSP90AA1,ESYT1,HSD17B12,ORMDL1,SLC16A1,ATP5MG,UGT3A1,KCNB1,TPH2,HAS3,ENTPD5,UGT2B7,GNPDA2,NAT1,PRKD1,NDUFAB1,SULT1C4,B4GALT5,L2HGDH,SLC45A2,CA9,BMAL1,HMGCR,SC5D,ADIPOR2,ALDH1L2,PGAM1,PSMD8,ACADM,SLC16A8,GSTA3,PARP16,LYPLA1,CACNB3,PLIN3,CMPK1,CYP26B1,MAT2B,ALOX12,UGT2B11,NCOA1,HBA1,PCTP,PLPP2,BDH2,PLCB3,CDS1,NT5C1A,FASN,SPTSSB,CHST5,PRELP,SLC2A3,GSTM3,PSMC2,SLC19A2,RBP2,RPS25,RPS11,ACSM1,APOF,PDPR,ATP5F1A,POR,RAB5A,PIP5K1B,GCG,CYP8B1,NOS3,LHB,BLVRA,SGPP2,B3GNT2,CERS2,SERINC1,NCOA2,KPNB1,HSD3B1,DEGS1,OXCT1,PHYH,PSMF1,IPMK,ACSF3,LPCAT3,CYP4F22,SLC2A1,CHST6,PSAP,NUP188,INSIG1,FMO2,SLC16A3,PLEKHA3,GNGT1,ERCC2,NEU3,KYNU,GGCT,RPL36AL,NDST1,IP6K1,MCEE,GPD1,STARD10,LDHAL6B,LPIN3,ENTPD1,UGDH,MAPKAPK2,SREBF2,MTMR6,SLC27A1,ENPP3,LBR,VAPB,PSMB6,ACSL3,PPARD,MED13L,CACNA2D2,PLA2R1,NDUFAF1,GPAT3,CLOCK,AMPD3,MED18,NCEH1,MIR3658,LRP12,SLC25A17,CHPF,OAZ1,CPNE1,ACMSD,HAGH,CSGALNACT1,ABCB4,PLA2G4A,AGPS,NUDT12,GNG8,CA3,SARS1,STARD3,CGA,CSAD,CEMIP,AGMAT,SERINC2,PI4KA,AIMP2,RPL22,COX15,CYB5B,CPOX,PIK3CA,GUCA2B,CIDEA,LDLRAP1,PLIN2,FXN,PMVK,ACAD8,TK1,ACAA1,ENPP2,PLD6,SLC26A1,PLD2,CHSY1,APOM,ADH4,SAR1B,AMACR,FABP4,INMT,INPP1,CYP2A7,SDHC,SYNJ1,GGT5,ELOVL2,NDUFV3,ARL2BP,PSMD2,ARSB,SNAP25,PRKACG,SLC37A4,CBR1,DUT,SGPP1,GNG10,GLYATL2,APOA5,VCAN,CHST9,NDUFV2,ACADSB,CD38,HS3ST4,COX5B,MLYCD,CDIPT,SARDH,TXNRD1,AGMO,UGT2A2,LIPN,ADHFE1,MOCS3,RPS27,INPP4A,GLS,STARD4,NDUFS8,ATP5PF,RXRA,UROS,SLC7A5,COX11,CYP4B1,PANK3,RPS21,GSTA5,UCP2,CYP2A6,ACLY,HYAL3,MTHFD2,GALC,RARS1,B4GALT4,APOC3,AADAC,DSEL,PYCR3,PNPLA2,CERS1,SLC44A2,MIR4647,B3GAT1,PLA2G2D,IDH1,DPYD,APOBR,CACNB2,DNM2,PSMD7,PGAM2,TPR,CHST12,CRYL1,RGL1,ACOT4,AHRR,FOLH1B,SDC4,ACP6,CALM2,SLC23A1,GSS,PTPMT1,VLDLR,SLC22A13,ATP5F1C,ATP5PD,CD36,PIP5K1A,XDH,AOC3,CYP2B6,ABCA1,ADIPOR1,PYCR1,MT1X,RPL27A,SUMF1,EPHX2,KARS1,MBOAT2,PPT1,HS3ST5,LIPM,MANBA,LIPI,RPS10,CHRM3,MGAM,POM121C,TECR,CHD9,FADS2,MDH2,GNG13,UGT2B4,RAP1A,HSD17B11,SCLY,MYLIP,PLA2G4D,HELZ2,NDUFAF2,ATP5PB,ITPKB,PTGES2,FABP3,ABHD4,NUP107,CYP4F8,KCNS3,SDC2,ZDHHC21,GATM,GCSH,SLC5A3,IMPA1,PSMD9,TPO,PRKCA,GDPD1,ARL2,UBC,SLC2A2,ACER2,SERINC5,PARP6,AOC1,ADH1C,B3GNT4,TAT,NDST4,NUP214,GLCE,SPHK1,AMY2B,CPNE3,SUCLA2,CREBBP,COMT,AKR7A3,GPD2,PLA2G3,ASPA,RRM1,UGT2B10,NDUFB6,SPR,HSD3B2,AANAT,KERA,BCKDK,LRP1,UGT1A9,OSBPL5,NT5C1B,AKR1B10,SLCO1B3,PTGES3,GAMT,DBI,PANK4,INSIG2,CYP2A13,NDUFA4,CYB5A,CHIA,GBA1,MIR1281,NRF1,CDO1,PTGS1,PSMD12,LIPK,MED4,DPYS,SLC19A3,NCOR1,SLC5A9,MIR4691,SLC25A11,ARF1,BCAT2,PNMT,TST,MTMR2,AASDHPPT,AKR1C3,TNFAIP8L3,GSR,SEH1L,CYP2R1,HSD17B4,SLC35D1,DPEP1,GSTT1,CPT1A,MED16,GUCY2C,PFKFB4,NUP88,PRKAR1B,CKM,ETNK2,AQP1,QARS1,PSMB3,SLC5A6,SPHK2,FAH,HAL,UGT8,CKMT1B,SPTLC3,CTH,CSNK2A1,COX6C,GYS2,HAO1,AKT1,RPE,RPL30,HBB,EPRS1,LIAS,ENO1,PSMD13,ITPKA,NUP93,GNA15,IARS1,PPM1L,LHX4-AS1,PNLIPRP2,CHST11,SPTLC2,PLCH1,MED13,OSBPL3,NUP133,ARNT,ACAA2,PRKAR1A,SLC5A4,CAT,MTF1,CES3,HSD17B3,ITPKC,PITPNB,PSMD6,DDAH1,SLC25A27,PC,THEM4,GALK1,SEM1,AK1,MTMR4,COQ5,TBL1XR1,VNN1,MED31,PPOX,HACD1,SLC3A2,CYP26A1,HEXB,MED19,CYP2C9,MED10,ALOX12B,APOC2,CHAC1,ARSI,PPP1CB,NME1,CHST13,CA2,CYP2C8,UGT1A6,LMF1,PPP1CA,SDHA,FABP12,NDUFA3,UGT1A4,ABHD5,GGTLC2,NUBPL,ETFA,MOCOS,SULT2A1,ADCY7,NNMT,GNB1,PPP1R3C,MED27,UPB1,AMT,ELOVL1,PIKFYVE,TCN1,PRKD2,N6AMT1,RPS7,PNP,PRKAB2,EEF1E1,ST3GAL3,RPS6,GCK,SGSH,UGT1A3,RPS3A,DECR1,PLCZ1,PYGB,MT3,CMBL,OAZ2,NUP35,UST,RTEL1,NDUFAF7,BCAT1,MED20,AKAP5,GNAS,ECI2,BCKDHB,TYRP1,CD44,NDUFA8,TIAM2,ATP5F1E,FBP1,TREH,AHR,ESYT3,PIK3R2,NDUFS5,PDSS2,SEC24C,PLCD1,PDK1,PLCD4,PRSS3,TECRL,BCO1,DARS1,APOB,ALDH7A1,XYLT1,CYP1B1,RPS3,ZDHHC8,UPP1,PPP2CB,MARCKS,GGT6,SULT1C2,ENTPD6,CNDP2,RRM2B,CYB5R3,GGT7,MGLL,SEC24A,GLYAT,SEC24D,NUBP1,GNPAT,SDC3,SLC25A21,GLO1,MED15,ACBD4,GCH1,XYLT2,CYP46A1,SMPD2,STARD7,HNMT,PRKAA2,PCSK6,MTTP,ALDH3A1,CES1,CYP1A1,SRM,GNG12,UGT1A8,AGK,SLC35B3,CIDEC,PARP9,MMUT,TNFAIP8L1,ITPR3,CDA,MGST1,PLCG1,HPD,NOSIP,PNPO,FDFT1,ALDH1L1,NDUFV1,ADCY2,CERS5,LRP10,ANKRD1,PSMA4,GNPDA1,NEU1,FDX2,FDX1,CYP17A1,TEAD4,ADI1,LALBA,PFKFB2,PARP14,ADCY4,TPH1,SLC6A7,PRKACB,ADH6,GALE,PSMD1,PI4K2B,CEPT1,EHHADH,UCP3,SMOX,CH25H,HACD4,CYB5R2,CYP27B1,RPS24,FABP1,SLC44A5,FAR1,WWTR1,CYP21A2,UQCRC1,HSD17B7,AKR7L,CA7,DHODH,IDO1,RPIA,TPTE2,NDUFAF5,RPS26,BPHL,PSMC1,CKMT1A,SREBF1,ACSS3,YAP1,COX4I1,MIR671,PANK1,GBA2,GNB3,GLUL,GNS,ACAT1,DAO,NCOA3,ACOT6,NDUFS2,DCTPP1,PFKFB3,CBLIF,CYP19A1,FABP2,SDHD,RPS23,BPNT1,COX20,RELN,HAO2,MFSD2A,ELOVL5,PPARG,CYP2C18,IDI1,HDAC3,ACSBG1,VAPA,GDPD3,CACNA1C,ENTPD7,MTMR7,GSTZ1,CERS6,PPP2R1B,TXN,COQ3,PPIP5K2,ST3GAL2,ALDH3B2,RDH11,SIN3B,LRPPRC,GNAQ,LCT,PGM1,MT4,PLD4,PI4KB,PTGES,CHST2,PLA2G5,ARSK,FECH,ABCC3,RPL19,NDUFA12,ACBD6,ETFDH,PLCB2,LDHA,PIP4K2A,CTRB1,TKT,CARM1,AGPAT5,ABCC5,COQ2,CYP4A22,ENPP1,PLD1,HADHB,GBA3,TIMMDC1,MAT1A,MED1,PSMA6,GPT2,PPP2R1A,HACD3,GSTA4,NR1H2,RPSA,PGM2,CERK,VAC14,AK7,ACOT7,STK11,OSBPL2,ACO2,DBH,PLTP,SPTLC1,PCK1,PCYT1A,DIO2,MIR4761,HSD11B1,ADRA2A,SORD,RPL34,ACAN,PAH,GBE1,NDUFB5,COQ7,ELOVL7,OSBPL8,G6PC1,SLC5A1,DLST,PRKAR2B,PCSK9,ASPG,NME4,FDPS,PRKD3,VAMP2,MAN2B1,NMNAT2,SGPL1,HAAO,DCT,IPPK,RPL39L,PSMD14,CSNK1G2,HSPG2,ABCC8,RSC1A1,NDUFA5,COX6B1,PHOSPHO1,RPL5,ACSL5,ACSM2A,SLC27A2,TM7SF2,OMD,PRKG2,STARD6,PLA2G4C,ADO,COQ6,SPTSSA,GMPR,DDO,ITPR2,AK5,INPP4B,SLC50A1,IDH2,HLCS,AZIN1,BSG,QPRT,CS,GSTA1,CYGB,ALDH3A2,PLA2G1B,LCLAT1,NAGS,MT2A,ALDH18A1,RPL14,POM121,COQ10B,CYP2F1,APIP,PPM1K,RPL29,PSME3,UGT2B15,OSBPL10,GSTA2,LRP2,APOA1,AACS,ENO3,SEC24B,RPL3L,CYCS,MMADHC,ENPP7,NT5C3A,RANBP2,ADSS2,CYP4F2,ITPR1,ETNPPL,SMPD1,CRYM,CA5A,CROT,PTDSS2,ARNT2,NDUFA9,ECSIT,MAN2C1,PNLIPRP3,NQO2,PNLIP,IDH3A,NFYA,PARP4,AKR1B15,MED26,MPC1,SUOX,PLCB1,RORA,FABP7,COX5A,PIPOX,NDUFA13,FAR2,SLC5A5,ACBD5,BMP1,SLC26A2,RFK,PRKAR2A,HMOX2,CSPG4,AOC2,ADSS1,ASRGL1,RAB14,ADIPOQ,PKM,PANK2,SHMT2,CYP24A1,PLEKHA4,AIP,DGAT2,PFAS,CYP2C19,RPL27,AASS,PEX11A,UQCRB,SULT1E1,PON1,INPP5K,APOE,GAPDH,KMO,B4GALT2,DDC,PLAAT5,PCBD1,RPS28,CYB5R4,NT5C,PRODH,AGXT2,TNFAIP8L2,XYLB,DCK,CLTA,ACOT12,ACOT13,SCAP,GLYATL1,ITPK1,MED25,NAXD,ABCD4,NAALAD2,MTHFS,ATIC,SLC25A2,THRAP3,FBP2,CAV1,ESYT2,LYRM4,ADH7,GNA11,RPL7,PSMD11,NUP98,ODC1,CHST15,GSTM1,SLC10A2,UGT2A3,CSNK2A2,PSMA8,PSMD4,GM2A,PDP1,PAPSS1,CDK19,PSMB4,MTMR3,KHK,VNN2,FFAR1,ENO2,SLC25A37,GYS1,HSD17B13,DMAC2L,RHAG,DAB1,DCTD,HACL1,ARSJ,PNPLA3,PLA2G12A,MIR631,HYAL1,SLC5A10,UGP2,SLC5A8,GMPR2,PLEKHA2,ACSM2B,PNLIPRP1,GMPS,RPL6,ELOVL4,GUSB,NCOR2,CHST3,NDUFA2,ASNS,CYP3A43,PLD3,COX7A2L,PKLR,GCKR,NUDT19,NQO1,ST3GAL6,SLC9A1,NUDT3,GPHN,ATP5F1B,PNPLA8,MGST3,GNGT2,TPI1,PPARA,PRKACA,NCOA6,NMRK2,PSMC6,MTR,ASAH2,SLC25A28,HPSE2,AHCY,LUM,SLC44A3,MED23,ACHE,SLC22A1,CERS3,IMPDH1,TYMS,B4GALT1,ACAD9,PIK3R6,P4HB,SECISBP2,CERT1,NDUFS6,ALPI,IP6K2,ASAH1,CYP11A1,POLD1,COX7C,TSHB,RPS19,ADCY5,TYR,RPL26L1,PIK3R1,GCLM,ACY3,PPP2CA,RPL32,SULT1A1,INPP5F,MGST2,ALDH6A1,NDUFB8,KYAT3,KCNJ11,CIAO3,CBR4,CALM3,UGT2A1,LPCAT1,ARG1,GNAI1,CHST1,PPARGC1A,GLIPR1,CDK8,NUP155,PLPP3,FURIN,HPSE,AGPAT3,GLYATL3,MRI1,TTR,OCA2,CES2,CERS4,MT1A,MT1F,MBTPS1,NPC1L1,NDUFS7,LARS1,ACSM6,B3GALT6,LRP8,ATP5MC3,STAB2,GNMT,LIPC,ABCG8,GPAT2,ACOT11,PIK3CD,LPA,GNB4,UROC1,SP1,HS2ST1,CYP11B2,SIN3A,PDK4,PLCG2,RPS8,PSMA5,MED9
R-HSA-196071	Metabolism of steroid hormones	0.0156573646289898	-4.15681388936355	32	32	0.00354217400929821	9034	10285	3292,3290,1589,3284,6716,1583,79644,3293,83930,231,134429,10948,1081,147323,6715,441282,1586,2230,2232,3283,51170,51144,112812,1584,3294,1588,1585,5443,51171,6770,3972,3291	HSD17B1,HSD11B1,CYP21A2,HSD3B2,SRD5A2,CYP11A1,SRD5A3,HSD17B3,STARD3NL,AKR1B1,STARD4,STARD3,CGA,STARD6,SRD5A1,AKR1B15,CYP17A1,FDX1,FDXR,HSD3B1,HSD17B11,HSD17B12,FDX2,CYP11B1,HSD17B2,CYP19A1,CYP11B2,POMC,HSD17B14,STAR,LHB,HSD11B2
R-HSA-948021	Transport to the Golgi and subsequent modification	0.0156608484351787	-4.15659141139546	164	153	0.0169360194819571	9034	10285	10342,1778,9871,3972,1783,10113,51046,22796,83548,10282,6710,23256,1315,378,10652,10905,51693,51128,9527,57134,2153,10972,5861,6708,79090,377,4124,1781,90411,23243,8774,64689,26984,22820,10802,2530,9117,22818,84342,1453,6709,10959,1075,7039,11196,84364,122553,11258,55738,6811,6712,26286,8702,51332,27095,79748,2525,54732,55291,8655,4121,25839,11014,84516,6484,51143,5537,966,10427,4247,4245,55014,26958,10175,57731,1604,6480,9334,100313843,1780,4249,375056,23423,10466,374,372,2683,51014,1639,8703,79694,11316,64377,51164,381,4122,83696,9486,11015,10960,338596,2517,6711,8615,91949,375,140735,11070,8729,7109,9570,51272,81876,6396,2801,1522,51226,2890,8128,10484,25834,57511,5265,11282,22872,1294,9331,287,10671,9554,254263,89866,3630,58485,4248,3998,63908,10540,286,1081,2804,10945,9632,2348,11320,128637,9276,8704,4905,4253,9382,149111,288	TFG,DYNC1H1,SEC24D,LHB,DYNC1LI2,PREB,ST8SIA3,COG2,COG3,BET1,SPTB,SCFD1,COPB1,ARF4,YKT6,MAN1A2,TRAPPC2L,SAR1B,GOSR1,MAN1C1,F5,TMED10,RAB1A,SPTA1,TRAPPC6A,ARF3,MAN2A1,DYNC1I2,MCFD2,ANKRD28,NAPG,GORASP1,SEC22A,COPG1,SEC24A,FUT8,SEC22C,COPZ1,COG8,CSNK1D,SPTAN1,TMED2,CTSC,TGFA,SEC23IP,ARFGAP2,TRAPPC6B,DCTN3,ARFGAP1,STX5,SPTBN2,ARFGAP3,B4GALT4,SPTBN5,TRAPPC3,LMAN1L,FUT3,TMED9,PPP6R3,DYNLL1,MAN1A1,COG4,KDELR2,DCTN5,ST3GAL4,DYNC1LI1,PPP6C,CD59,SEC24B,MGAT2,MGAT1,STX17,COPG2,CNIH1,SPTBN4,CD55,ST6GAL1,B4GALT5,MIR711,DYNC1I1,MGAT5,MIA3,TMED3,COG5,AREG,ARCN1,B4GALT1,TMED7,DCTN1,B4GALT3,MANEA,COPE,CHST8,DCTN4,ARF5,MAN2A2,TRAPPC9,CHST10,KDELR3,LMAN2,ST8SIA6,FUCA1,SPTBN1,USO1,COG7,ARF1,DYNLL2,TMEM115,GBF1,TRAPPC10,GOSR2,BET1L,RAB1B,SEC13,GOLGA2,CTSZ,COPZ2,GRIA1,ST8SIA2,SEC23A,MGAT4C,COG6,SERPINA1,MGAT4B,SEC31A,COL7A1,B4GALT6,ANK2,DCTN6,SEC22B,CNIH2,SEC16B,INS,TRAPPC1,MGAT3,LMAN1,NAPB,DCTN2,ANK1,CGA,GOLGB1,KDELR1,SEC24C,FOLR1,MGAT4A,TBC1D20,COPB2,B4GALT2,NSF,MIA2,COG1,CNIH3,ANK3
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation	0.016107048577349	-4.12849830296277	61	59	0.00653088332964357	9034	10285	10092,7410,10810,10095,8976,5595,71,10096,998,9103,2214,10163,3984,10458,55845,10097,51517,2212,6850,1072,60,4644,5058,10552,2209,147179,10109,10787,1793,4651,1398,10094,23191,10006,5747,2885,3320,10451,3071,7409,5594,917,919,63916,4620,10152,26999,3326,4627,7456,644150,9844,8936,5879,4641,4690,25,4650,10093	ARPC5,VAV2,WASF3,ARPC1B,WASL,MAPK3,ACTG1,ACTR3,CDC42,FCGR2C,FCGR3A,WASF2,LIMK1,BAIAP2,BRK1,ACTR2,NCKIPSD,FCGR2A,SYK,CFL1,ACTB,MYO5A,PAK1,ARPC1A,FCGR1A,WIPF2,ARPC2,NCKAP1,DOCK1,MYO10,CRK,ARPC3,CYFIP1,ABI1,PTK2,GRB2,HSP90AA1,VAV3,NCKAP1L,VAV1,MAPK1,CD3G,CD247,ELMO2,MYH2,ABI2,CYFIP2,HSP90AB1,MYH9,WIPF1,WIPF3,ELMO1,WASF1,RAC1,MYO1C,NCK1,ABL1,MYO9B,ARPC4
R-HSA-112043	PLC beta mediated events	0.0167452359750059	-4.08964148056857	47	46	0.00509187513836617	9034	10285	5568,808,2773,5332,5566,2770,10768,196883,2781,5573,3709,5567,115,23236,114,5136,805,5577,2780,5321,5575,2771,5137,5578,406974,5576,5580,112,156,5330,3710,111,2779,1385,346562,814,107,109,113,5594,3708,801,108,5331,5153,5582	PRKACG,CALM3,GNAI3,PLCB4,PRKACA,GNAI1,AHCYL1,ADCY4,GNAZ,PRKAR1A,ITPR2,PRKACB,ADCY9,PLCB1,ADCY8,PDE1A,CALM2,PRKAR2B,GNAT2,PLA2G4A,PRKAR1B,GNAI2,PDE1C,PRKCA,MIR197,PRKAR2A,PRKCD,ADCY6,GRK2,PLCB2,ITPR3,ADCY5,GNAT1,CREB1,GNAT3,CAMK4,ADCY1,ADCY3,ADCY7,MAPK1,ITPR1,CALM1,ADCY2,PLCB3,PDE1B,PRKCG
R-HSA-418990	Adherens junctions interactions	0.0178330130969819	-4.0267038710881	31	31	0.00343148107150764	9034	10285	1013,283,3728,1010,1012,1495,1003,5819,1000,1009,1002,999,1499,64403,57863,23705,1001,25945,5817,81607,1005,4301,1016,253559,1007,1500,5818,1004,1008,1015,1006	CDH15,ANG,JUP,CDH12,CDH13,CTNNA1,CDH5,NECTIN2,CDH2,CDH11,CDH4,CDH1,CTNNB1,CDH24,CADM3,CADM1,CDH3,NECTIN3,PVR,NECTIN4,CDH7,AFDN,CDH18,CADM2,CDH9,CTNND1,NECTIN1,CDH6,CDH10,CDH17,CDH8
R-HSA-5654687	Downstream signaling of activated FGFR1	0.0178330130969819	-4.0267038710881	31	31	0.00343148107150764	9034	10285	4893,2885,2251,10817,2249,9365,27006,2255,26281,2260,3845,10818,5335,23769,2254,5781,5290,8822,23768,2246,2549,23767,2248,3265,6464,5295,8074,2253,2247,2250,6654	NRAS,GRB2,FGF6,FRS3,FGF4,KL,FGF22,FGF10,FGF20,FGFR1,KRAS,FRS2,PLCG1,FLRT1,FGF9,PTPN11,PIK3CA,FGF17,FLRT2,FGF1,GAB1,FLRT3,FGF3,HRAS,SHC1,PIK3R1,FGF23,FGF8,FGF2,FGF5,SOS1
R-HSA-74752	Signaling by Insulin receptor	0.0180617990637207	-4.01395612002325	322	295	0.0326544166482178	9034	10285	3265,84078,5694,8682,5707,5605,6233,3562,2253,5528,5718,3559,4254,5700,2260,2243,27006,9365,2251,25780,28956,3082,4233,54106,9048,1437,408,8992,5720,25759,51719,207,2244,11221,818,2066,7414,5155,1977,155066,3558,8437,6198,245973,54756,389541,2475,5156,5691,8074,27040,2065,8660,23545,526,208,5693,2534,57761,529,2887,817,51422,5719,5529,5290,1846,9693,7450,5781,3674,100847012,64096,2254,5527,5717,3084,30849,5519,117145,2064,57521,2246,53358,9861,5708,115727,3667,6708,3690,5154,10048,283455,7248,84335,685,245972,7010,5692,535,3643,2255,6710,58528,5571,51606,122706,4893,143471,5710,10125,7979,1844,23198,88,5536,57731,5696,1439,5623,10542,5604,533,2252,5695,1978,1843,284,8831,3716,3845,5908,5786,10312,815,51332,53632,5518,5894,8817,9542,5687,6709,1950,5037,7249,801,5245,81617,5706,2266,2248,10718,2549,2906,6194,3815,5711,8826,4684,673,5565,6711,6794,8649,2668,10142,2905,409,6009,10818,5595,5699,26281,7311,5684,805,4902,153090,10670,64926,100847046,152559,9978,5713,10256,5295,10213,5140,29904,6714,1975,5698,54518,528,90423,5979,8452,50617,4747,5296,3560,9114,816,5714,5702,5516,4763,1847,399473,3630,5562,3567,2249,1850,9462,3718,5922,4296,64223,2674,2885,5906,5747,5515,8822,7314,1445,92335,4140,55004,80824,5525,5715,5682,84292,7529,145957,200734,808,9550,6654,5526,5921,2250,1849,5289,9965,161742,523,2247,2335,2261,5701,9491,2676,10197,64121,5923,2903,2069,10817,5563,2263,2675,5159,7316,5924,6464,2904,5564,10156,2264,5291,5704,51382,8315,1839,1956,55437,127124,5686,1981,5690,6712,525,1742,5494,3717,5685,221002,1848,3568,5170,5594	HRAS,KBTBD7,PSMB6,PEA15,PSMD1,MAP2K2,RPS27A,IL3,FGF8,PPP2R5D,PSMD12,IL2RA,KITLG,PSMC1,FGFR1,FGA,FGF22,KL,FGF6,RASGRP3,LAMTOR2,HGF,MET,TLR9,ARTN,CSF2,ARRB1,ATP6V0E1,PSME1,SHC2,CAB39,AKT1,FGB,DUSP10,CAMK2G,ERBB4,VCL,PDGFB,EIF4E,ATP6V0E2,IL2,RASAL1,RPS6KB1,ATP6V1C2,IL17RD,LAMTOR4,MTOR,PDGFRA,PSMB3,FGF23,LAT,ERBB3,IRS2,ATP6V0A2,ATP6V1B2,AKT2,PSMB5,FYN,TRIB3,ATP6V1E1,GRB10,CAMK2D,PRKAG2,PSMD13,PPP2R5E,PIK3CA,DUSP4,RAPGEF2,VWF,PTPN11,ITGA2B,MIR5004,GFRA4,FGF9,PPP2R5C,PSMD11,NRG1,PIK3R4,PPP2R1B,THEM4,ERBB2,RPTOR,FGF1,SHC3,PSMD6,PSMD2,RASGRP4,IRS1,SPTA1,ITGB3,PDGFA,RANBP9,KSR2,TSC1,AKT1S1,BTC,ATP6V0D2,TEK,PSMB4,ATP6V0A1,INSR,FGF10,SPTB,RRAGD,PRKAG1,ATP6V1H,PSMB11,NRAS,PSMA8,PSMD4,RASGRP1,SEM1,DUSP2,PSME4,ACTN2,PPP5C,SPTBN4,PSMB8,CSF2RB,PSPN,LAMTOR5,MAP2K1,ATP6V0B,FGF7,PSMB7,EIF4EBP1,DUSP1,ANGPT1,SYNGAP1,JAK1,KRAS,RAP1B,PTPRA,TCIRG1,CAMK2A,SPTBN5,PRKAG3,PPP2R1A,RAF1,FGF18,NRG2,PSMA6,SPTAN1,EGF,PEBP1,TSC2,CALM1,PHB1,CAB39L,PSMC6,FGG,FGF3,NRG3,GAB1,GRIN2D,RPS6,KIT,PSMD5,IQGAP1,NCAM1,BRAF,PRKAB2,SPTBN1,STK11,LAMTOR3,GDNF,AKAP9,GRIN2C,ARRB2,RHEB,FRS2,MAPK3,PSMB10,FGF20,UBA52,PSMA3,CALM2,NRTN,DAB2IP,RRAGA,RASAL3,MIR5010,PAQR3,RBX1,PSMD7,CNKSR1,PIK3R1,PSMD14,PDE3B,EEF2K,SRC,EIF4B,PSMB9,APBB1IP,ATP6V1C1,ATP6V1E2,RET,CUL3,ATP6V0A4,NEFL,PIK3R2,IL2RB,ATP6V0D1,CAMK2B,PSMD8,PSMC3,PPP2CB,NF1,DUSP5,SPRED3,INS,PRKAA1,IL5,FGF4,DUSP8,RASAL2,JAK3,RASA2,MAP3K11,MLST8,GFRA1,GRB2,RAP1A,PTK2,PPP2CA,FGF17,UBB,CSK,STRADA,MARK3,LAMTOR1,DUSP16,PPP2R5A,PSMD9,PSMA1,WDR83,YWHAB,NRG4,SPRED2,CALM3,ATP6V1G1,SOS1,PPP2R5B,RASA1,FGF5,DUSP7,PIK3C3,FGF19,SPRED1,ATP6V1A,FGF2,FN1,FGFR3,PSMC2,PSMF1,GFRA3,PSME3,RRAGC,RASGRF1,GRIN2A,EREG,FRS3,PRKAA2,FGFR2,GFRA2,PDGFRB,UBC,RASGRF2,SHC1,GRIN2B,PRKAB1,RASA4,FGFR4,PIK3CB,PSMC4,ATP6V1D,BRAP,HBEGF,EGFR,STRADB,ATP6V1G3,PSMA5,EIF4G1,PSMB2,SPTBN2,ATP6V1B1,DLG4,PPM1A,JAK2,PSMA4,RASGEF1A,DUSP6,IL5RA,PDPK1,MAPK1
R-HSA-70153	Glucose transport	0.0187220756353501	-3.97805193612246	46	45	0.0049811822005756	9034	10285	6514,81929,9631,8086,85414,129401,4928,7175,4927,2538,9883,8021,79902,2646,55746,57122,10762,23636,57818,2645,55974,348995,2542,3099,3101,55706,9688,11097,9818,3098,144195,79023,6515,6517,6513,53371,23225,9972,92579,5903,100101267,23165,23511,26291,23279	SLC2A2,SEH1L,NUP155,AAAS,SLC45A3,NUP35,NUP98,TPR,NUP88,G6PC1,POM121,NUP214,NUP85,GCKR,NUP133,NUP107,NUP50,NUP62,G6PC2,GCK,SLC50A1,NUP43,SLC37A4,HK2,HK3,NDC1,NUP93,NUP42,NUP58,HK1,SLC2A14,NUP37,SLC2A3,SLC2A4,SLC2A1,NUP54,NUP210,NUP153,G6PC3,RANBP2,POM121C,NUP205,NUP188,FGF21,NUP160
R-HSA-8863795	Downregulation of ERBB2 signaling	0.0203107007226258	-3.8966074026248	30	30	0.00332078813371707	9034	10285	8065,9542,7314,1950,7316,100302213,10000,208,7311,2069,3320,6233,2065,9101,1956,1839,26469,685,11140,55914,3084,5782,2064,10718,145957,207,10273,4145,10193,2066	CUL5,NRG2,UBB,EGF,UBC,MIR1181,AKT3,AKT2,UBA52,EREG,HSP90AA1,RPS27A,ERBB3,USP8,EGFR,HBEGF,PTPN18,BTC,CDC37,ERBIN,NRG1,PTPN12,ERBB2,NRG3,NRG4,AKT1,STUB1,MATK,RNF41,ERBB4
R-HSA-111996	Ca-dependent events	0.0203107007226258	-3.8966074026248	30	30	0.00332078813371707	9034	10285	814,5567,109,107,115,1385,5573,196883,5566,111,156,808,5568,5576,108,5153,112,5582,5580,5137,5578,801,5594,5321,5577,5575,113,5136,114,805	CAMK4,PRKACB,ADCY3,ADCY1,ADCY9,CREB1,PRKAR1A,ADCY4,PRKACA,ADCY5,GRK2,CALM3,PRKACG,PRKAR2A,ADCY2,PDE1B,ADCY6,PRKCG,PRKCD,PDE1C,PRKCA,CALM1,MAPK1,PLA2G4A,PRKAR2B,PRKAR1B,ADCY7,PDE1A,ADCY8,CALM2
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	0.0203393427111201	-3.89519820397137	443	403	0.0446092539295993	9034	10285	10256,10287,57406,9978,2791,64926,5580,1910,5737,10818,2668,10161,8649,6375,673,2147,2793,2911,5706,4295,80824,2642,2867,4140,1445,7314,5331,5515,2885,2674,3718,4296,399473,1847,5516,5702,5714,816,5296,6714,7200,5295,2069,94233,2796,9491,846,5701,2335,84634,5588,6846,1849,2250,6654,2869,5332,200734,808,2915,145957,11343,5682,623,2641,5594,59345,1848,3269,6915,6869,353299,3717,5685,5686,2149,23620,84109,146,55970,3814,2264,156,2792,2904,5924,3710,1437,9048,56923,3082,2783,64106,2243,27006,5021,2260,431704,5998,4254,5718,5528,8526,5605,3562,23236,1609,2693,8525,84078,6870,301,3060,1608,3674,2254,7450,5719,2769,5529,817,5693,64407,5691,5156,8437,5155,7414,11221,25759,23198,88,5997,5598,8477,10887,1844,2837,7979,143471,5710,122706,4893,594857,7204,552,6710,5692,2151,2864,685,1906,3667,9861,10235,2246,2064,2786,2767,5717,5527,5245,5037,1902,1950,9542,747,3356,815,147,51332,5786,3845,2782,5908,1607,8831,1385,257313,5695,54331,2520,8503,128674,5623,1439,5696,5536,5713,152559,3062,5367,5028,153090,8997,4902,805,5684,351,7311,26281,10886,5699,5595,409,2150,10142,2829,2905,1908,6711,4684,8826,5711,2788,3815,8527,2906,885,2922,10718,2248,2266,1128,51738,183,1909,221955,51764,5031,1133,185,8822,5906,5747,5922,9462,1850,2249,3567,4763,57121,5029,3560,4922,4747,5979,8452,5698,54518,10213,1131,4829,6368,5578,7316,5159,2675,160851,5724,2263,10817,2903,5923,10197,2676,4923,2261,23566,5020,57113,161742,2247,9965,5921,2787,9162,5526,3709,5032,1907,887,7529,1241,84292,5525,5715,84539,3708,3357,3568,553,221002,1606,29933,1742,6712,5690,6288,1839,57105,10911,1956,8315,6195,5704,10156,624,6464,3061,6196,408,4233,25780,28956,2251,2798,9365,3559,5700,2253,6233,7225,6866,347148,5707,8682,2862,5694,9630,3265,6865,2865,129521,100847012,64096,10874,1846,9693,2358,5290,26090,2534,7222,8660,8074,94235,27040,2065,551,54756,60675,3558,2784,2066,818,2244,5720,4314,886,6863,5583,2797,10125,222545,5731,2255,2776,7010,8111,387129,10048,5154,283455,6708,3690,115727,115557,5708,5581,53358,2790,5519,3084,10681,801,3827,7201,6709,2847,8817,5687,5894,5518,10316,3716,284,1843,2252,5330,5604,148,57731	CNKSR1,RGS19,ABHD6,RBX1,GNG11,RASAL3,PRKCD,EDNRB,PTGFR,FRS2,GDNF,LPAR6,LAMTOR3,XCL1,BRAF,F2,GNGT2,GRM1,PSMC6,MLN,DUSP16,GCGR,FFAR2,MARK3,CSK,UBB,PLCB3,PPP2CA,GRB2,GFRA1,JAK3,MAP3K11,SPRED3,DUSP5,PPP2CB,PSMC3,PSMD8,CAMK2B,PIK3R2,SRC,TRH,PIK3R1,EREG,OPN4,GNRH1,PSMF1,CASR,PSMC2,FN1,KISS1R,PRKCQ,XCL2,DUSP7,FGF5,SOS1,GRK5,PLCB4,SPRED2,CALM3,GRM5,NRG4,MGLL,PSMA1,BDKRB1,GCG,MAPK1,GNB4,DUSP6,HRH1,TBXA2R,TACR1,RGSL1,JAK2,PSMA4,PSMA5,F2R,NTSR2,QRFPR,ADRA1D,GNG12,KISS1,FGFR4,GRK2,GNGT1,GRIN2B,RASGRF2,ITPR3,CSF2,ARTN,NMUR2,HGF,GNB2,NPFFR1,FGA,FGF22,OXTR,FGFR1,RGS21,RGS3,KITLG,PSMD12,PPP2R5D,DGKE,MAP2K2,IL3,PLCB1,DGKQ,GHSR,DGKZ,KBTBD7,TACR3,ANXA1,HCRT,DGKG,ITGA2B,FGF9,VWF,PSMD13,GNA15,PPP2R5E,CAMK2D,PSMB5,RGS18,PSMB3,PDGFRA,RASAL1,PDGFB,VCL,DUSP10,SHC2,PSME4,ACTN2,RGS2,MAPK7,GPR65,PROKR1,DUSP2,UTS2R,SEM1,PSMA8,PSMD4,PSMB11,NRAS,NPS,TRIO,AVPR1A,SPTB,PSMB4,F2RL2,FFAR1,BTC,EDN1,IRS1,PSMD6,RASGRP2,FGF1,ERBB2,GNG4,GNA11,PSMD11,PPP2R5C,PHB1,PEBP1,LPAR1,EGF,NRG2,DAGLA,HTR2A,CAMK2A,ADRA1B,SPTBN5,PTPRA,KRAS,GNB1,RAP1B,DGKB,SYNGAP1,CREB1,UTS2B,PSMB7,GNG2,GAST,PIK3R3,PROKR2,PSPN,CSF2RB,PSMB8,PPP5C,PSMD7,PAQR3,HCRTR2,PMCH,P2RY1,DAB2IP,KALRN,NRTN,CALM2,PSMA3,APP,UBA52,FGF20,NPFFR2,PSMB10,MAPK3,ARRB2,F2RL1,AKAP9,XCR1,GRIN2C,EDN3,SPTBN1,NCAM1,IQGAP1,PSMD5,GNG7,KIT,DGKD,GRIN2D,CCK,GRP,NRG3,FGF3,FGG,CHRM1,GHRL,AGT,EDNRA,DAGLB,GNG13,P2RY6,CHRM5,AGTR1,FGF17,RAP1A,PTK2,RASA2,RASAL2,DUSP8,FGF4,IL5,NF1,LPAR5,P2RY2,IL2RB,NTS,NEFL,RET,CUL3,PSMB9,APBB1IP,PSMD14,CHRM3,NMBR,CCL23,PRKCA,UBC,PDGFRB,GFRA2,DGKH,PTAFR,FGFR2,FRS3,GRIN2A,RASGRF1,PSME3,GFRA3,NTSR1,FGFR3,LPAR3,OXT,TRPC7,SPRED1,FGF2,FGF19,RASA1,GNG5,DGKI,PPP2R5B,ITPR2,P2RY11,EDN2,CCKBR,YWHAB,LTB4R,WDR83,PPP2R5A,PSMD9,MCHR2,ITPR1,HTR2B,IL5RA,AVPR1B,RASGEF1A,DGKA,GPR132,DLG4,SPTBN2,PSMB2,SAA1,HBEGF,CYSLTR2,UTS2,EGFR,BRAP,RPS6KA1,PSMC4,RASA4,BDKRB2,SHC1,HCRTR1,RPS6KA2,ARRB1,MET,RASGRP3,LAMTOR2,FGF6,GNRHR,KL,IL2RA,PSMC1,FGF8,RPS27A,TRPC6,TAC3,QRFP,PSMD1,PEA15,MLNR,PSMB6,GNA14,HRAS,TACR2,FFAR3,NMS,MIR5004,GFRA4,NMU,DUSP4,RAPGEF2,FPR2,PIK3CA,ABHD12,FYN,TRPC3,IRS2,FGF23,GNG8,LAT,ERBB3,AVP,IL17RD,PROK2,IL2,GNB3,ERBB4,CAMK2G,FGB,PSME1,MMP3,CCKAR,TAC1,PRKCH,GNRH2,RASGRP1,GPRC6A,PTGER1,FGF10,GNAQ,TEK,GPR68,NPSR1,RANBP9,PDGFA,KSR2,SPTA1,ITGB3,RASGRP4,ARHGEF25,PSMD2,PRKCE,SHC3,GNG10,PPP2R1B,NRG1,GNB5,CALM1,KNG1,TRHR,SPTAN1,MCHR1,FGF18,PSMA6,RAF1,PPP2R1A,NMUR1,JAK1,ANGPT1,DUSP1,FGF7,PLCB2,MAP2K1,ADRA1A,SPTBN4
R-HSA-400253	Circadian Clock	0.020757926517393	-3.87482710441096	71	68	0.00752711976975869	9034	10285	23373,8945,10891,1407,23054,2908,5465,1454,1408,64784,200186,56938,1628,8841,6095,8553,150094,9611,6233,406,2155,2033,4208,1374,7311,7316,28999,9575,10499,79718,10743,8864,6256,1390,6500,4209,9572,1386,26224,5499,79365,10498,551,6720,1387,5936,1385,8204,6604,5500,5054,4862,5501,5187,25819,8454,100302237,85441,1453,10135,8648,80205,23411,5469,96764,3091,7314,4783	CRTC1,BTRC,PPARGC1A,CRY1,NCOA6,NR3C1,PPARA,CSNK1E,CRY2,CRTC3,CRTC2,BMAL2,DBP,HDAC3,RORA,BHLHE40,SIK1,NCOR1,RPS27A,BMAL1,F7,EP300,MEF2C,CPT1A,UBA52,UBC,KLF15,CLOCK,NCOA2,TBL1XR1,RAI1,PER2,RXRA,CREM,SKP1,MEF2D,NR1D1,ATF2,FBXL3,PPP1CA,BHLHE41,CARM1,AVP,SREBF1,CREBBP,RBM4,CREB1,NRIP1,SMARCD3,PPP1CB,SERPINE1,NPAS2,PPP1CC,PER1,NOCT,CUL1,MIR1281,HELZ2,CSNK1D,NAMPT,NCOA1,CHD9,SIRT1,MED1,TGS1,HIF1A,UBB,NFIL3
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	0.0227593094987878	-3.78278100855031	70	67	0.00741642683196812	9034	10285	3312,22824,2932,53371,51501,9972,23225,3309,23511,23279,259217,100101267,23165,5903,9531,9530,5594,9818,6767,6119,11097,9688,55706,23411,9529,79023,51182,9261,472,10049,3304,55746,6782,3310,10808,6118,116835,545,57122,79902,3313,7266,348995,3337,573,10762,23636,6117,4928,7175,9532,3305,129401,9631,81929,27000,8086,57805,3306,8021,7531,9883,3308,4927,3311,5595,91582	HSPA8,HSPA4L,GSK3B,NUP54,HIKESHI,NUP153,NUP210,HSPA5,NUP188,NUP160,HSPA12A,POM121C,NUP205,RANBP2,BAG3,BAG4,MAPK1,NUP58,ST13,RPA3,NUP42,NUP93,NDC1,SIRT1,BAG5,NUP37,HSPA14,MAPKAPK2,ATM,DNAJB6,HSPA1B,NUP133,HSPA13,HSPA6,HSPH1,RPA2,HSPA12B,ATR,NUP107,NUP85,HSPA9,DNAJC7,NUP43,DNAJB1,BAG1,NUP50,NUP62,RPA1,NUP98,TPR,BAG2,HSPA1L,NUP35,NUP155,SEH1L,DNAJC2,AAAS,CCAR2,HSPA2,NUP214,YWHAE,POM121,HSPA4,NUP88,HSPA7,MAPK3,RPS19BP1
R-HSA-525793	Myogenesis	0.0231323205560813	-3.76652448109235	29	29	0.0032100951959265	9034	10285	6929,1499,4654,91653,4656,4617,4756,4205,4208,5600,4618,6300,998,4917,1013,1496,663,9043,25,100271849,1495,6925,1432,5608,6938,50937,4209,1000,1002	TCF3,CTNNB1,MYOD1,BOC,MYOG,MYF5,NEO1,MEF2A,MEF2C,MAPK11,MYF6,MAPK12,CDC42,NTN3,CDH15,CTNNA2,BNIP2,SPAG9,ABL1,MEF2B,CTNNA1,TCF4,MAPK14,MAP2K6,TCF12,CDON,MEF2D,CDH2,CDH4
R-HSA-375170	CDO in myogenesis	0.0231323205560813	-3.76652448109235	29	29	0.0032100951959265	9034	10285	998,4208,4618,6300,5600,4617,4656,4205,4756,4654,91653,6929,1499,50937,5608,6938,1000,4209,1002,1495,6925,1432,25,100271849,1013,4917,663,9043,1496	CDC42,MEF2C,MYF6,MAPK12,MAPK11,MYF5,MYOG,MEF2A,NEO1,MYOD1,BOC,TCF3,CTNNB1,CDON,MAP2K6,TCF12,CDH2,MEF2D,CDH4,CTNNA1,TCF4,MAPK14,ABL1,MEF2B,CDH15,NTN3,BNIP2,SPAG9,CTNNA2
R-HSA-1296072	Voltage gated Potassium channels	0.0233773824259553	-3.75598628703507	44	43	0.00475979632499447	9034	10285	8514,3755,3743,3757,3739,56479,3751,81033,3749,3742,7881,9312,170850,23415,3756,23416,26251,3754,3744,3736,3748,9196,3785,3787,169522,93107,3746,3738,27133,27012,131096,3790,3741,26290,3752,3737,90134,3786,9132,3784,3788,3745,3747	KCNAB2,KCNG1,KCNA7,KCNH2,KCNA4,KCNQ5,KCND2,KCNH6,KCNC4,KCNA6,KCNAB1,KCNB2,KCNG3,KCNH4,KCNH1,KCNH3,KCNG2,KCNF1,KCNA10,KCNA1,KCNC3,KCNAB3,KCNQ2,KCNS1,KCNV2,KCNG4,KCNC1,KCNA3,KCNH5,KCNV1,KCNH8,KCNS3,KCNA5,GALNT8,KCND3,KCNA2,KCNH7,KCNQ3,KCNQ4,KCNQ1,KCNS2,KCNB1,KCNC2
R-HSA-1474290	Collagen formation	0.0235832339918638	-3.7472192434949	93	88	0.00974097852557007	9034	10285	1300,1293,169044,9509,5339,5351,3918,649,5118,10491,1281,84695,64175,8985,1298,3691,1278,1306,140766,5034,3655,871,1307,1305,100313843,1302,283208,1284,91522,100422894,7093,131873,3914,7373,1299,84171,1520,5033,1514,57642,1294,1289,9508,4017,4015,79709,4316,4016,1508,100126326,7092,136227,1286,1290,1303,1515,1310,1285,10536,55214,1280,1308,1296,50509,4314,81578,1277,1297,23127,1295,1301,340267,26577,84570,5479,85301,8974,4322,1282,977,667,255631,100500837,3909,9313,4318,5352,256076	COL10A1,COL6A3,COL22A1,ADAMTS2,PLEC,PLOD1,LAMC2,BMP1,PCOLCE,CRTAP,COL3A1,LOXL3,P3H1,PLOD3,COL9A2,ITGB4,COL1A2,COL15A1,ADAMTS14,P4HB,ITGA6,SERPINH1,COL16A1,COL13A1,MIR711,COL11A2,P4HA3,COL4A2,COL23A1,MIR4260,TLL2,COL6A6,LAMB3,COL14A1,COL9A3,LOXL4,CTSS,P4HA1,CTSL,COL20A1,COL7A1,COL5A1,ADAMTS3,LOXL2,LOX,COLGALT1,MMP7,LOXL1,CTSB,MIR936,TLL1,COL26A1,COL4A4,COL5A2,COL12A1,CTSV,COL19A1,COL4A3,P3H3,P3H2,COL2A1,COL17A1,COL8A2,COL5A3,MMP3,COL21A1,COL1A1,COL9A1,COLGALT2,COL8A1,COL11A1,COL28A1,PCOLCE2,COL25A1,PPIB,COL27A1,P4HA2,MMP13,COL4A1,CD151,DST,COL24A1,MIR3606,LAMA3,MMP20,MMP9,PLOD2,COL6A5
R-HSA-73923	Lipid digestion, mobilization, and transport	0.0239996138027989	-3.72971754031371	115	108	0.0119548372813814	9034	10285	19,337,161,1213,3991,8513,10062,149998,340654,26291,348,8435,1071,1149,128486,338,213,2,3988,84699,336,6646,29801,29116,55908,5125,9619,2169,2534,1211,26119,1056,5501,5408,2173,81693,5567,142910,643414,649,55911,949,5566,2168,5360,27329,57552,341,29923,1175,2171,255738,7436,5034,4023,5500,1600,344,345275,8029,335,643418,2172,100616211,5499,64788,63924,29881,160,8720,5407,4018,163,51099,4864,64241,3990,646486,338328,119548,5406,51129,345,1208,7376,200879,319,646480,5649,2167,2170,51128,10577,3949,1173,116519,11343,857,5568,23491,5045,51599,3069,4547,5346,5046,64240,9388	ABCA1,APOA4,AP2A2,CLTC,LIPE,LIPF,NR1H3,LIPI,LIPM,FGF21,APOE,SOAT2,CETP,CIDEA,FITM2,APOB,ALB,A2M,LIPA,CREB3L3,APOA2,SOAT1,ZDHHC8,MYLIP,ANGPTL8,PCSK5,ABCG1,FABP2,FYN,CLTA,LDLRAP1,CEL,PPP1CC,PNLIPRP2,FABP7,AMN,PRKACB,LIPJ,LIPK,BMP1,APOBR,SCARB1,PRKACA,FABP1,PLTP,ANGPTL3,NCEH1,APOC1,HILPDA,AP2S1,FABP5,PCSK9,VLDLR,P4HB,LPL,PPP1CB,DAB1,APOC2,HSD17B13,CUBN,APOA1,LIPN,FABP6,MIR4709,PPP1CA,LMF1,CIDEC,NPC1L1,AP2A1,MBTPS1,PNLIPRP1,LPA,AP2B1,ABHD5,NPC1,ABCG8,LIPC,FABP12,GPIHBP1,PNLIPRP3,PNLIP,ANGPTL4,APOC3,CLPS,NR1H2,LIPH,APOF,FABP9,RELN,FABP4,FABP3,SAR1B,NPC2,LDLR,AP2M1,APOA5,MGLL,CAV1,PRKACG,CES3,FURIN,LSR,HDLBP,MTTP,PLIN1,PCSK6,ABCG5,LIPG
R-HSA-425407	SLC-mediated transmembrane transport	0.0241511009912152	-3.72342531022438	287	263	0.0291122426389196	9034	10285	66035,285195,92579,6564,23225,121260,6513,140679,6579,51000,9123,23279,159963,23511,5903,1497,28234,6505,6530,206358,9818,9187,6506,6522,55867,79751,6511,57122,11182,23443,64078,64116,808,6550,6526,10599,7781,55974,9356,6561,9056,6547,83697,6557,682,56606,6563,84102,9631,6514,6540,9883,8021,23657,6578,100506403,23539,6538,26291,6559,100101267,23165,81539,6248,123041,55706,284111,6549,213,23446,340024,6515,1468,144195,10864,6512,10568,6548,2646,6566,79902,6521,57153,100616124,57468,6570,85413,9194,2645,6565,57818,30061,51458,9376,1811,23516,6539,7175,129401,115111,284129,126969,28965,29988,246213,55315,2538,114134,805,29985,6580,57835,57084,6523,6558,146802,6536,54716,6005,64849,23428,9972,116085,7779,8671,9197,8140,6584,51296,6507,160728,6569,125206,345274,28231,11309,801,154091,115286,55244,11097,6518,64924,3101,6542,124935,9153,57419,8501,3098,6574,6519,55343,6527,6717,80024,4891,55746,6581,6568,81031,9990,26503,9057,6546,2542,9154,3099,23636,53919,10762,283652,57282,117247,3177,5172,5002,4928,56301,8086,9498,11136,55356,57181,6571,1317,6556,6520,83733,2030,6583,25800,10991,6510,8884,551,60482,80736,84912,57030,389015,222962,53371,25769,54407,11046,6531,348932,148867,353189,115584,55089,23315,10559,9688,8170,6533,55676,6517,6529,1356,23382,6582,79023,283375,10861,26266,347734,6508,10723,155184,376497,6534,200010,6509,6541,91749,348995,57127,10999,133418,153201,55117,6553,6528,204962,115019,6543,1836,6575,6560,254428,28232,85414,169026,7780,81929,23169,9497,4927,861,9152,29986	SLC2A11,SLC9A9,G6PC3,SLC15A1,NUP210,SLC15A4,SLC2A1,SLC32A1,SLCO1A2,SLC35B3,SLC16A3,NUP160,SLC5A12,NUP188,RANBP2,CTNS,SLCO1B3,SLC1A1,SLC6A2,SLC36A1,NUP58,SLC24A1,SLC1A2,SLC4A2,SLC22A11,SLC25A22,SLC1A6,NUP107,SLC2A6,SLC35A3,SLC28A3,SLC39A8,CALM3,SLC9A3,SLC5A3,SLCO1B1,SLC30A3,SLC50A1,SLC22A6,SLC13A1,SLC7A7,SLC8A3,SLC4A9,SLC12A1,BSG,SLC2A9,SLC14A1,SLC41A2,NUP155,SLC2A2,SLC6A13,POM121,NUP214,SLC7A11,SLCO2A1,LOC100506403,SLC16A8,SLC6A11,FGF21,SLC12A3,POM121C,NUP205,SLC38A1,RSC1A1,SLC24A4,NDC1,SLC13A5,SLC9A2,ALB,SLC44A1,SLC6A19,SLC2A3,SLC25A10,SLC2A14,SLC22A7,SLC1A7,SLC34A2,SLC9A1,GCKR,SLC16A1,NUP85,SLC4A1,SLC44A2,MIR4647,SLC12A5,SLC18A1,SLC22A16,SLC16A7,GCK,SLC15A2,G6PC2,SLC40A1,RHCG,SLC22A8,SLC26A3,SLC39A14,SLC6A12,TPR,NUP35,SLC26A7,SLC26A11,SLC44A3,SLC27A6,SLC2A8,SLC17A8,SLC29A3,G6PC1,SLC2A13,CALM2,SLC39A3,SLC22A1,SLC4A5,SLC17A6,SLC5A1,SLC12A2,SLC47A2,SLC6A9,SLC6A20,RHAG,SLC13A3,SLC7A8,NUP153,SLC22A12,SLC30A1,SLC4A4,SLC33A1,SLC7A5,SLC22A5,SLC15A3,SLC1A3,SLC5A8,SLC34A1,SLC5A10,SLC10A6,SLCO4A1,SLCO2B1,CALM1,SLC2A12,SLC25A26,SLC47A1,NUP42,SLC2A5,SLC30A5,HK3,SLC7A2,SLC43A2,SLC28A2,SLC24A3,SLC43A1,HK1,SLC20A1,SLC3A1,SLC35C1,SLC5A4,SRI,SLC8B1,SLC11A2,NUP133,SLC22A3,SLC17A1,SLC2A10,SLC12A6,SLC17A5,SLC7A6,SLC8A1,SLC37A4,SLC28A1,HK2,NUP62,SLCO1C1,NUP50,SLC24A5,SLC4A10,SLC16A10,SLC29A2,SLC26A4,SLC22A18,NUP98,SLC7A10,AAAS,SLC4A8,SLC7A9,SLC22A15,SLC39A10,SLC18A2,SLC31A1,SLC11A1,SLC3A2,SLC25A18,SLC29A1,SLC22A4,SLC39A6,SLC38A3,SLC1A5,SLC5A6,AVP,SLC5A7,SLC44A4,SLC35B4,SLC17A7,SLC9A4,SLC29A4,NUP54,SLC24A2,SLC38A2,SLC35D2,SLC6A3,SLC6A18,SLC30A7,SLCO4C1,SLC5A11,SLC38A4,SLC9A8,SLC35A1,NUP93,SLC14A2,SLC6A6,SLC30A6,SLC2A4,SLC6A1,CP,AHCYL2,SLC22A2,NUP37,SLC39A5,SLC26A1,SLC13A4,SLC35B2,SLC4A3,SLC12A7,SLC2A7,SLC27A1,SLC6A7,SLC5A9,SLC1A4,SLC7A1,MFSD4B,NUP43,RHBG,SLC27A4,EMB,SLC36A2,SLC6A15,SLC9A5,SLC5A5,SLC44A5,SLC26A9,SLC8A2,SLC26A2,SLC20A2,SLC12A4,SLC41A1,SLCO3A1,SLC45A3,SLC30A8,SLC30A2,SEH1L,SLC35D1,SLC4A7,NUP88,RUNX1,SLC6A5,SLC39A2
R-HSA-375276	Peptide ligand-binding receptors	0.0243705269314848	-3.71438078944153	188	174	0.019260571175559	9034	10285	1237,6755,2920,60675,27202,3577,50865,551,10874,1230,5173,2358,2919,129521,3060,9718,51083,301,6865,6870,3627,2693,2862,347148,6866,2359,6370,5021,7852,64106,6366,718,6387,5443,56923,4887,6752,4889,6751,2532,9283,128674,122042,3792,339403,257313,10316,117579,2357,4160,2861,2847,6753,51289,10563,7201,2826,3827,6364,6754,6357,1906,387129,727,256933,6363,3579,2151,4985,1524,552,594857,4986,10887,728,2837,886,6863,4829,3576,1235,8484,7200,4161,10663,4922,1236,1325,51052,2587,2834,6372,729230,185,4157,1909,6750,4295,10803,8811,51738,183,6376,2922,885,1889,6360,2147,1908,719,6375,2829,2150,5539,4886,10022,58191,10886,3640,1910,351,10850,2831,1232,9034,4988,5179,5367,3062,3061,2832,6374,624,3814,5660,5697,5196,10911,23620,84109,57007,4852,2149,6288,51554,6352,4158,187,6869,643,2921,1233,553,623,84539,4159,1907,887,57486,56477,84634,1234,5020,6846,4923,4987,5368,6373,5540,6019,6346,2852,59350,6368	CCR8,SSTR5,CXCL2,PROK2,C5AR2,CXCR1,HEBP1,AVP,NMU,CCR1,PDYN,FPR2,CXCL1,NMS,HCRT,ECE2,GAL,ANXA1,TACR2,TACR3,CXCL10,GHSR,MLNR,QRFP,TAC3,FPR3,CCL25,OXTR,CXCR4,NPFFR1,CCL21,C3,CXCL12,POMC,NMUR2,NPY2R,SSTR2,NPY5R,SSTR1,ACKR1,GPR37L1,PROKR2,RXFP2,KEL,RXFP4,UTS2B,NMUR1,RLN3,FPR1,MC4R,GPR37,MCHR1,SSTR3,RXFP3,CXCL13,TRHR,CCR10,KNG1,CCL20,SSTR4,CCL13,EDN1,NPSR1,C5,NPB,CCL19,CXCR2,F2RL2,OPRD1,CX3CR1,AVPR1A,NPS,OPRK1,PROKR1,C5AR1,UTS2R,CCKAR,TAC1,NMBR,CXCL8,CCR6,GALR3,TRH,MC5R,CXCR6,NTS,CCR7,CORT,PRLH,GALR1,PRLHR,CXCL6,CCR2,AGTR1,MC1R,EDNRA,SST,MLN,CCR9,GALR2,GHRL,AGT,CX3CL1,GRP,CCK,ECE1,CCL16,F2,EDN3,C3AR1,XCL1,XCR1,F2RL1,PPY,NPY1R,INSL5,CXCL16,NPFFR2,INSL3,EDNRB,APP,CCL27,NPBWR1,CCR3,CCRL2,OPRM1,PENK,PMCH,HCRTR2,HCRTR1,NPBWR2,CXCL5,BDKRB2,KISS1,PSAP,PYY,PF4,UTS2,NTSR2,QRFPR,ACKR3,NPY,F2R,SAA1,ACKR4,CCL5,MC2R,APLNR,TACR1,CXCR5,CXCL3,CCR4,AVPR1B,BDKRB1,MCHR2,MC3R,EDN2,CCKBR,NLN,CCL28,KISS1R,CCR5,OXT,XCL2,NTSR1,OPRL1,PNOC,CXCL11,NPY4R,RLN2,CCL1,GPER1,RXFP1,CCL23
R-HSA-202733	Cell surface interactions at the vascular wall	0.0248225108144688	-3.69600434338459	136	127	0.0140580030994023	9034	10285	6383,50848,9056,857,634,3685,3687,7010,6402,2734,2335,482,9057,3690,6654,5478,4893,5624,6520,5672,9463,3675,29802,23657,682,56301,51744,9046,9672,3676,961,11136,58494,5291,5175,8140,9123,5197,483,5676,4099,5680,6464,284,1048,2995,5196,5675,23428,5777,440533,54210,5670,2207,285,3845,8793,4680,5335,10461,7441,2888,10544,2994,3265,1084,4067,6566,3688,2817,83953,4312,2147,5669,4282,3655,8832,960,3683,4973,51206,6404,6385,3932,51378,5678,972,6714,4072,1088,6382,5295,962,914,83700,8797,3684,8795,5671,120425,3635,23539,6403,3543,5296,7056,2885,23759,481,5673,2534,2993,6401,965,90952,5781,55423,140885,7525,1525,5627,7040,338,6693,3689,5290,3512	SDC2,F11R,SLC7A7,CAV1,CEACAM1,ITGAV,ITGAX,TEK,SELL,GLG1,FN1,ATP1B2,SLC7A6,ITGB3,SOS1,PPIA,NRAS,PROC,SLC3A2,PSG4,PICK1,ITGA3,VPREB3,SLC7A11,BSG,SLC7A10,CD244,DOK2,SDC3,ITGA4,CD47,SLC7A9,JAM2,PIK3CB,PECAM1,SLC7A5,SLC16A3,PF4V1,ATP1B3,PSG7,MAG,PSG11,SHC1,ANGPT1,CEACAM5,GYPC,PF4,PSG6,SLC7A8,PTPN6,PSG8,TREM1,PSG2,FCER1G,ANGPT2,KRAS,TNFRSF10D,CEACAM6,PLCG1,MERTK,VPREB1,GRB14,PROCR,GYPB,HRAS,CEACAM3,LYN,SLC16A1,ITGB1,GPC1,FCAMR,MMP1,F2,PSG1,MIF,ITGA6,CD84,CD44,ITGAL,OLR1,GP6,SELPLG,SDC4,LCK,ANGPT4,PSG9,CD74,SRC,EPCAM,CEACAM8,SDC1,PIK3R1,CD48,CD2,JAM3,TNFRSF10A,ITGAM,TNFRSF10B,PSG3,JAML,INPP5D,SLC16A8,SELP,IGLL1,PIK3R2,THBD,GRB2,PPIL2,ATP1B1,PSG5,FYN,GYPA,SELE,CD58,ESAM,PTPN11,SIRPG,SIRPA,YES1,CXADR,PROS1,TGFB1,APOB,SPN,ITGB2,PIK3CA,JCHAIN
R-HSA-6806834	Signaling by MET	0.0249412843285647	-3.69123084332141	69	66	0.00730573389417755	9034	10285	3913,8027,3675,7311,64759,6457,6455,3082,4893,3910,4233,6456,7316,85440,23163,6692,3918,10319,3265,26018,2549,3908,3911,6654,6233,6774,10048,84951,5867,9101,3673,57610,3688,3915,2889,5908,3845,5770,3083,1398,2060,5747,3912,5906,2885,5290,10254,867,284217,7314,9146,5781,3909,3249,100422894,6464,5295,3914,6714,200958,5795,382,10653,5879,5771,100616340	LAMB2,STAM,ITGA3,UBA52,TNS3,SH3GL3,SH3GL1,HGF,NRAS,LAMA4,MET,SH3GL2,UBC,DOCK7,GGA3,SPINT1,LAMC2,LAMC3,HRAS,LRIG1,GAB1,LAMA2,LAMA5,SOS1,RPS27A,STAT3,RANBP9,TNS4,RAB4A,USP8,ITGA2,RANBP10,ITGB1,LAMC1,RAPGEF1,RAP1B,KRAS,PTPN1,HGFAC,CRK,EPS15,PTK2,LAMB1,RAP1A,GRB2,PIK3CA,STAM2,CBL,LAMA1,UBB,HGS,PTPN11,LAMA3,HPN,MIR4260,SHC1,PIK3R1,LAMB3,SRC,MUC20,PTPRJ,ARF6,SPINT2,RAC1,PTPN2,MIR4758
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	0.0255667135863334	-3.66646402408967	92	87	0.0096302855877795	9034	10285	284348,420,9488,8434,2822,9091,51299,54742,146183,130576,4061,84628,10232,4045,154064,23556,266727,284098,5279,8876,146760,54344,53942,171169,2813,6975,137797,8875,22854,50863,80740,23627,1048,419,5283,1087,2350,7070,123904,161357,338328,1043,51227,55650,58530,683,5281,27076,135228,4978,8581,116372,83639,9487,353091,360226,7007,646627,251,84720,5067,55350,10026,80055,1368,5329,248,390243,349633,8813,147719,128869,4241,93183,10942,54965,2215,8000,4062,80328,249,54872,152330,257194,51604,8818,349667	LYPD5,ART4,PIGB,RECK,GPLD1,PIGQ,NRN1,LY6K,OTOA,LYPD6B,LY6E,NTNG2,MSLN,LSAMP,RAET1L,PIGN,MDGA1,PIGW,PIGC,VNN1,RTN4RL1,DPM3,CNTN5,SPACA4,GP2,TECTB,LYPD2,VNN2,NTNG1,NTM,LY6G6C,PRND,CEACAM5,ART3,PIGH,CEACAM7,FOLR2,THY1,NRN1L,MDGA2,GPIHBP1,CD52,PIGP,PIGV,LY6G6D,BST1,PIGF,LYPD3,CD109,OPCML,LY6D,LYPD1,TEX101,PIGL,RAET1G,PRSS41,TECTA,LYPD8,ALPG,PIGO,CNTN3,VNN3P,PIGK,PGAP1,CPM,PLAUR,ALPI,IZUMO1R,PLET1,DPM1,LYPD4,PIGU,MELTF,PIGM,PRSS21,PIGX,FCGR3B,PSCA,LY6H,ULBP2,ALPL,PIGG,CNTN4,NEGR1,PIGT,DPM2,RTN4RL2
R-HSA-112314	Neurotransmitter Receptor Binding And Downstream Transmission In The  Postsynaptic Cell	0.0257044101495674	-3.66109270065227	146	136	0.0150542395395174	9034	10285	1742,815,27092,2782,3762,113,59345,5170,163,2561,5594,801,10681,5894,1142,108,2893,2550,27020,160,80852,5330,1137,1135,6196,5924,2904,2557,2891,2792,2555,23426,1136,1385,3772,6195,814,3759,55970,5579,109,107,2898,54331,6237,114,5923,2903,3760,9463,2899,406974,5578,88,84254,112,100126325,5568,808,8973,2036,1173,2569,2786,1145,3766,2790,2770,1146,55584,2787,2901,115,9568,3765,2774,10368,83988,817,2566,2890,2567,5331,5582,51764,2570,818,2897,4193,2784,4905,2560,4646,111,2558,161,816,94235,1144,346562,4747,1138,2900,3763,2783,9495,805,1739,2771,2791,1175,1139,1143,2559,3768,2906,2793,2773,2788,1141,2562,3265,5566,2905,10142,2554,3761,196883,10369,3773,673,1134,59283,23236,5567,200959	DLG4,CAMK2A,CACNG4,GNB1,KCNJ5,ADCY7,GNB4,PDPK1,AP2B1,GABRB2,MAPK1,CALM1,GNB5,RAF1,CHRNB3,ADCY2,GRIA4,GABBR1,NPTN,AP2A1,GRIP2,PLCB2,CHRNA4,CHRNA2,RPS6KA2,RASGRF2,GRIN2B,GABRA4,GRIA2,GNGT1,GABRA2,GRIP1,CHRNA3,CREB1,KCNJ15,RPS6KA1,CAMK4,KCNJ2,GNG12,PRKCB,ADCY3,ADCY1,GRIK2,GNG2,RRAS,ADCY8,RASGRF1,GRIN2A,KCNJ3,PICK1,GRIK3,MIR197,PRKCA,ACTN2,CAMKK1,ADCY6,MIR935,PRKACG,CALM3,CHRNA6,EPB41L1,AP2M1,GABRR1,GNG4,CHRNE,KCNJ10,GNG10,GNAI1,CHRNG,CHRNA9,GNG5,GRIK5,ADCY9,GABBR2,KCNJ9,GNAL,CACNG3,NCALD,CAMK2D,GABRG2,GRIA1,GABRG3,PLCB3,PRKCG,GNG13,GABRR2,CAMK2G,GRIK1,MDM2,GNB3,NSF,GABRB1,MYO6,ADCY5,GABRA5,AP2A2,CAMK2B,GNG8,CHRND,GNAT3,NEFL,CHRNA5,GRIK4,KCNJ6,GNB2,AKAP5,CALM2,DLG1,GNAI2,GNG11,AP2S1,CHRNA7,CHRNB4,GABRA6,KCNJ12,GRIN2D,GNGT2,GNAI3,GNG7,CHRNB2,GABRB3,HRAS,PRKACA,GRIN2C,AKAP9,GABRA1,KCNJ4,ADCY4,CACNG2,KCNJ16,BRAF,CHRNA1,CACNG8,PLCB1,PRKACB,GABRR3
R-HSA-5173105	O-linked glycosylation	0.0258296231393155	-3.65623326201894	114	107	0.0118441443435909	9034	10285	9510,221981,170691,200958,374907,192134,7057,6482,54507,29954,27090,114805,2590,727897,118430,9331,11096,9719,3742,57188,63917,11095,9508,168391,50614,120071,146712,10331,81794,10164,11227,26290,56667,9509,9215,6487,157869,57452,79875,84892,143662,2650,9334,6480,140687,140453,4585,10417,374378,140766,56999,51146,84002,51809,81792,84752,170690,6484,442117,54437,171019,56913,2591,55624,4589,55568,11174,9507,11173,94025,394263,339366,9037,79695,8693,9245,7058,1605,79623,11093,10071,2589,80731,117248,23145,11226,11041,10585,4583,92949,10678,145173,10418,55901,148789,80070,10610,6483,170692,93010,79369,64409,4588,23275,256435,170689,51301	ADAMTS1,THSD7A,ADAMTS17,MUC20,B3GNT8,B3GNT6,THBS1,ST3GAL1,ADAMTSL4,POMT2,ST6GALNAC4,GALNT13,GALNT2,MUC5B,MUCL1,B4GALT6,ADAMTS5,ADAMTSL2,KCNA6,ADAMTSL3,GALNT11,ADAMTS8,ADAMTS3,GALNTL5,GALNT9,LARGE2,B3GNTL1,B3GNT3,ADAMTS10,CHST4,GALNT5,GALNT8,MUC13,ADAMTS2,LARGE1,ST3GAL3,SBSPON,GALNT16,THSD4,POMGNT2,MUC15,GCNT1,B4GALT5,ST6GAL1,GCNT7,MUC17,MUC4,SPON2,GALNT18,ADAMTS14,ADAMTS9,A4GNT,B3GNT5,GALNT7,ADAMTS12,B3GNT9,ADAMTS16,ST3GAL4,GALNTL6,SEMA5B,ADAMTS19,C1GALT1,GALNT3,POMGNT1,MUC7,GALNT10,ADAMTS6,ADAMTS4,ADAMTS7,MUC16,MUC21,ADAMTSL5,SEMA5A,GALNT12,GALNT4,GCNT3,THBS2,DAG1,GALNT14,ADAMTS13,MUC12,GALNT1,THSD7B,GALNT15,SSPOP,GALNT6,B4GAT1,POMT1,MUC2,ADAMTSL1,B3GNT2,B3GLCT,SPON1,THSD1,B3GALNT2,ADAMTS20,ST6GALNAC2,ST3GAL2,ADAMTS18,B3GNT7,B3GNT4,GALNT17,MUC6,POFUT2,ST6GALNAC3,ADAMTS15,GCNT4
R-HSA-194068	Bile acid and bile salt metabolism	0.0261073528854296	-3.64553828458079	43	42	0.0046491033872039	9034	10285	114883,51302,6554,8647,26031,11001,10005,114876,1593,9971,10858,8309,10499,3295,213,6555,8648,28234,8644,570,1581,9420,80765,1582,6718,114880,9023,6579,5007,6256,1646,1109,10599,114881,8714,80270,9885,6342,23600,2172,5740,1645	OSBPL9,CYP39A1,SLC10A1,ABCB11,OSBPL3,SLC27A2,ACOT8,OSBPL1A,CYP27A1,NR1H4,CYP46A1,ACOX2,NCOA2,HSD17B4,ALB,SLC10A2,NCOA1,SLCO1B3,AKR1C3,BAAT,CYP7A1,CYP7B1,STARD5,CYP8B1,AKR1D1,OSBPL6,CH25H,SLCO1A2,OSBP,RXRA,AKR1C2,AKR1C4,SLCO1B1,OSBPL7,ABCC3,HSD3B7,OSBPL2,SCP2,AMACR,FABP6,PTGIS,AKR1C1
R-HSA-111997	CaM pathway	0.0263455709462736	-3.63645510365313	28	28	0.00309940225813593	9034	10285	5573,196883,1385,109,107,115,5567,814,156,5568,808,5566,111,801,5578,5137,5582,112,5580,5153,5576,108,805,114,5136,113,5575,5577	PRKAR1A,ADCY4,CREB1,ADCY3,ADCY1,ADCY9,PRKACB,CAMK4,GRK2,PRKACG,CALM3,PRKACA,ADCY5,CALM1,PRKCA,PDE1C,PRKCG,ADCY6,PRKCD,PDE1B,PRKAR2A,ADCY2,CALM2,ADCY8,PDE1A,ADCY7,PRKAR1B,PRKAR2B
R-HSA-2022854	Keratan sulfate biosynthesis	0.0263455709462736	-3.63645510365313	28	28	0.00309940225813593	9034	10285	8703,9331,5549,8702,23563,93010,2683,79369,6483,4060,10678,9334,6482,176,4969,8534,11046,8704,6487,11081,11041,2331,4166,6484,4958,9435,10402,10331	B4GALT3,B4GALT6,PRELP,B4GALT4,CHST5,B3GNT7,B4GALT1,B3GNT4,ST3GAL2,LUM,B3GNT2,B4GALT5,ST3GAL1,ACAN,OGN,CHST1,SLC35D2,B4GALT2,ST3GAL3,KERA,B4GAT1,FMOD,CHST6,ST3GAL4,OMD,CHST2,ST3GAL6,B3GNT3
R-HSA-111933	Calmodulin induced events	0.0263455709462736	-3.63645510365313	28	28	0.00309940225813593	9034	10285	5573,196883,1385,814,109,107,115,5567,156,5568,808,5566,111,5137,801,5578,5576,108,5582,112,5580,5153,5136,114,805,5575,5577,113	PRKAR1A,ADCY4,CREB1,CAMK4,ADCY3,ADCY1,ADCY9,PRKACB,GRK2,PRKACG,CALM3,PRKACA,ADCY5,PDE1C,CALM1,PRKCA,PRKAR2A,ADCY2,PRKCG,ADCY6,PRKCD,PDE1B,PDE1A,ADCY8,CALM2,PRKAR1B,PRKAR2B,ADCY7
R-HSA-422356	Regulation of insulin secretion	0.0267862040288244	-3.61986829905135	80	76	0.00841266327208324	9034	10285	5578,150,402,26251,776,2771,2740,2791,6514,112,5576,2783,9495,114,2778,2776,291,5577,5575,2864,3747,3745,5573,10768,5567,6812,23236,3767,2787,3790,3709,8826,777,2788,6861,6616,775,23568,5568,2793,9630,5566,2770,2790,783,2786,2641,9254,2767,10681,3708,773,59345,6833,51764,5331,2769,11069,5906,10411,3630,2782,4082,152,94235,54331,6844,6513,55970,784,2784,5330,111,2792,1131,3710	PRKCA,ADRA2A,ARL2,KCNG2,CACNA1D,GNAI2,GLP1R,GNG11,SLC2A2,ADCY6,PRKAR2A,GNB2,AKAP5,ADCY8,GNAS,GNAQ,SLC25A4,PRKAR2B,PRKAR1B,FFAR1,KCNC2,KCNB1,PRKAR1A,AHCYL1,PRKACB,STXBP1,PLCB1,KCNJ11,GNG5,KCNS3,ITPR2,IQGAP1,CACNA1E,GNG7,SYT5,SNAP25,CACNA1C,ARL2BP,PRKACG,GNGT2,GNA14,PRKACA,GNAI1,GNG10,CACNB2,GNG4,GCG,CACNA2D2,GNA11,GNB5,ITPR1,CACNA1A,GNB4,ABCC8,GNG13,PLCB3,GNA15,RAPGEF4,RAP1A,RAPGEF3,INS,GNB1,MARCKS,ADRA2C,GNG8,GNG2,VAMP2,SLC2A1,GNG12,CACNB3,GNB3,PLCB2,ADCY5,GNGT1,CHRM3,ITPR3
R-HSA-2871796	FCERI mediated MAPK activation	0.027475924365509	-3.59444513538182	265	243	0.0268983838831083	9034	10285	5336,1742,6712,5609,5690,5686,5335,5594,3568,1848,7409,221002,4214,5685,3717,5704,2264,10156,2904,6464,5924,1956,1839,8315,2263,10817,2069,7410,2903,5923,10197,2676,9491,5159,7316,2675,808,200734,145957,7529,84292,5682,5715,5525,5701,9402,2261,2335,2247,161742,9965,1849,2250,5921,5526,6654,5747,2674,5906,2885,4296,3718,5922,9462,6416,2249,1850,3567,399473,1847,4763,5516,5702,80824,4140,1445,7314,5515,8822,8452,5979,54518,5698,6714,10213,5714,816,2353,3560,4747,805,5684,7311,5699,26281,5595,10818,10256,5713,9978,152559,64926,153090,4902,5711,3815,2906,10718,2248,2266,4067,5706,409,2905,2668,10142,8649,6711,673,4684,8826,5518,815,51332,10451,5786,5908,3845,3716,5245,801,5037,1950,6709,5687,8817,9542,5894,5604,5623,1439,5696,57731,5536,8831,5879,284,1843,5695,2252,5599,122706,4893,6710,2255,5692,88,23198,1844,7979,10125,5710,143471,115727,5708,9861,53358,2246,2064,6850,5519,5527,5717,3084,7010,685,5601,283455,10048,5154,3690,6708,3667,817,5693,2534,5602,2254,64096,3674,100847012,1846,9693,7450,5719,5529,8437,3558,5062,5155,7414,2066,818,2244,11221,25759,5720,8660,2065,8074,27040,5691,5156,54756,3082,25780,2251,28956,27006,9365,2243,2260,5700,3559,4254,3937,408,1437,9048,4233,8682,5694,84078,3265,3725,5718,5528,2253,3562,5058,5605,6233,5707	PLCG2,DLG4,SPTBN2,MAP2K7,PSMB2,PSMA5,PLCG1,MAPK1,IL5RA,DUSP6,VAV1,RASGEF1A,MAP3K1,PSMA4,JAK2,PSMC4,FGFR4,RASA4,GRIN2B,SHC1,RASGRF2,EGFR,HBEGF,BRAP,FGFR2,FRS3,EREG,VAV2,GRIN2A,RASGRF1,PSME3,GFRA3,PSMF1,PDGFRB,UBC,GFRA2,CALM3,SPRED2,NRG4,YWHAB,WDR83,PSMA1,PSMD9,PPP2R5A,PSMC2,GRAP2,FGFR3,FN1,FGF2,SPRED1,FGF19,DUSP7,FGF5,RASA1,PPP2R5B,SOS1,PTK2,GFRA1,RAP1A,GRB2,MAP3K11,JAK3,RASA2,RASAL2,MAP2K4,FGF4,DUSP8,IL5,SPRED3,DUSP5,NF1,PPP2CB,PSMC3,DUSP16,MARK3,CSK,UBB,PPP2CA,FGF17,CUL3,RET,APBB1IP,PSMB9,SRC,PSMD14,PSMD8,CAMK2B,FOS,IL2RB,NEFL,CALM2,PSMA3,UBA52,PSMB10,FGF20,MAPK3,FRS2,CNKSR1,PSMD7,RBX1,PAQR3,RASAL3,DAB2IP,NRTN,PSMD5,KIT,GRIN2D,NRG3,FGF3,FGG,LYN,PSMC6,ARRB2,GRIN2C,GDNF,AKAP9,LAMTOR3,SPTBN1,BRAF,NCAM1,IQGAP1,PPP2R1A,CAMK2A,SPTBN5,VAV3,PTPRA,RAP1B,KRAS,JAK1,PHB1,CALM1,PEBP1,EGF,SPTAN1,PSMA6,FGF18,NRG2,RAF1,MAP2K1,PSPN,CSF2RB,PSMB8,SPTBN4,PPP5C,SYNGAP1,RAC1,ANGPT1,DUSP1,PSMB7,FGF7,MAPK8,PSMB11,NRAS,SPTB,FGF10,PSMB4,ACTN2,PSME4,DUSP2,SEM1,RASGRP1,PSMD4,PSMA8,RASGRP4,PSMD2,PSMD6,SHC3,FGF1,ERBB2,SYK,PPP2R1B,PPP2R5C,PSMD11,NRG1,TEK,BTC,MAPK9,KSR2,RANBP9,PDGFA,ITGB3,SPTA1,IRS1,CAMK2D,PSMB5,FYN,MAPK10,FGF9,GFRA4,ITGA2B,MIR5004,DUSP4,RAPGEF2,VWF,PSMD13,PPP2R5E,RASAL1,IL2,PAK2,PDGFB,VCL,ERBB4,CAMK2G,FGB,DUSP10,SHC2,PSME1,IRS2,ERBB3,FGF23,LAT,PSMB3,PDGFRA,IL17RD,HGF,RASGRP3,FGF6,LAMTOR2,FGF22,KL,FGA,FGFR1,PSMC1,IL2RA,KITLG,LCP2,ARRB1,CSF2,ARTN,MET,PEA15,PSMB6,KBTBD7,HRAS,JUN,PSMD12,PPP2R5D,FGF8,IL3,PAK1,MAP2K2,RPS27A,PSMD1
R-HSA-418346	Platelet homeostasis	0.0277033725597914	-3.58620112013908	91	86	0.00951959264998893	9034	10285	80228,100616453,5321,5138,50940,27094,5025,5136,2778,5027,2783,805,489,5152,487,5026,6543,2791,3778,4846,5527,2786,5525,5519,5051,8654,2790,6547,808,2793,2982,2788,2268,5526,3709,2787,6546,7225,5023,6717,57113,5593,5528,488,2782,5516,10846,7222,490,10242,5518,5529,5515,338,27345,5024,51764,5153,5781,491,84876,59345,3708,801,10681,6786,3710,2983,2792,5140,1432,7804,5139,5175,2784,3779,5777,55970,5592,5739,54331,10335,2977,493,94235,4842	ORAI2,MIR4687,PLA2G4A,PDE2A,PDE11A,KCNMB3,P2RX4,PDE1A,GNAS,P2RX7,GNB2,CALM2,ATP2A3,PDE9A,ATP2A1,P2RX5,SLC8A2,GNG11,KCNMA1,NOS3,PPP2R5C,GNG4,PPP2R5A,PPP2R1B,PAFAH2,PDE5A,GNG10,SLC8A3,CALM3,GNGT2,GUCY1A1,GNG7,FGR,PPP2R5B,ITPR2,GNG5,SLC8A1,TRPC6,P2RX1,SRI,TRPC7,PRKG2,PPP2R5D,ATP2A2,GNB1,PPP2CB,PDE10A,TRPC3,ATP2B1,KCNMB2,PPP2R1A,PPP2R5E,PPP2CA,APOB,KCNMB4,P2RX3,GNG13,PDE1B,PTPN11,ATP2B2,ORAI1,GNB4,ITPR1,CALM1,GNB5,STIM1,ITPR3,GUCY1B1,GNGT1,PDE3B,MAPK14,LRP8,PDE3A,PECAM1,GNB3,KCNMB1,PTPN6,GNG12,PRKG1,PTGIR,GNG2,IRAG1,GUCY1A2,ATP2B4,GNG8,NOS1
R-HSA-373752	Netrin-1 signaling	0.0291441722537651	-3.53550030885671	42	41	0.00453841044941333	9034	10285	8633,137970,7225,3983,56963,219699,5306,6585,5879,6091,5588,4690,1793,57113,116986,7430,6714,148738,6586,285704,6478,22885,9423,4756,5335,5781,7220,7222,4651,59277,8976,1630,9353,998,5747,84448,6477,7223,2534,7204,90249	UNC5C,UNC5D,TRPC6,ABLIM1,RGMA,UNC5B,PITPNA,SLIT1,RAC1,ROBO1,PRKCQ,NCK1,DOCK1,TRPC7,AGAP2,EZR,SRC,HJV,SLIT3,RGMB,SIAH2,ABLIM3,NTN1,NEO1,PLCG1,PTPN11,TRPC1,TRPC3,MYO10,NTN4,WASL,DCC,SLIT2,CDC42,PTK2,ABLIM2,SIAH1,TRPC4,FYN,TRIO,UNC5A
R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	0.0291441722537651	-3.53550030885671	42	41	0.00453841044941333	9034	10285	94235,3745,5573,3747,3709,3790,8826,55970,2787,5567,54331,5568,2793,2784,2788,2641,3710,2786,2790,2792,111,5566,26251,59345,2791,2740,3708,10681,5576,112,51764,114,2778,2783,9495,11069,5906,5575,5577,2782,10411	GNG8,KCNB1,PRKAR1A,KCNC2,ITPR2,KCNS3,IQGAP1,GNG12,GNG5,PRKACB,GNG2,PRKACG,GNGT2,GNB3,GNG7,GCG,ITPR3,GNG4,GNG10,GNGT1,ADCY5,PRKACA,KCNG2,GNB4,GNG11,GLP1R,ITPR1,GNB5,PRKAR2A,ADCY6,GNG13,ADCY8,GNAS,GNB2,AKAP5,RAPGEF4,RAP1A,PRKAR1B,PRKAR2B,GNB1,RAPGEF3
R-HSA-6807878	COPI-mediated anterograde transport	0.0291537365199662	-3.53517219189718	79	75	0.00830197033429267	9034	10285	51332,26286,11258,6712,55738,6811,3630,54732,10671,287,10959,84342,22818,51226,6709,57511,84364,9276,10945,2348,26958,9382,288,57731,4905,25839,11014,8655,966,286,2804,63908,84516,10540,51143,378,83548,372,51014,1315,10282,6710,381,51164,1639,10652,11316,1604,1783,1778,22796,1780,10466,23423,11070,8729,1781,9570,375,8615,91949,140735,377,2801,81876,8774,51272,22820,64689,9527,11015,10972,6711,6708,5861	SPTBN5,ARFGAP3,DCTN3,SPTBN2,ARFGAP1,STX5,INS,TMED9,DCTN6,ANK2,TMED2,COG8,COPZ1,COPZ2,SPTAN1,COG6,ARFGAP2,COPB2,KDELR1,FOLR1,COPG2,COG1,ANK3,SPTBN4,NSF,COG4,KDELR2,DYNLL1,CD59,ANK1,GOLGB1,NAPB,DCTN5,DCTN2,DYNC1LI1,ARF4,COG3,ARCN1,TMED7,COPB1,BET1,SPTB,ARF5,DCTN4,DCTN1,YKT6,COPE,CD55,DYNC1LI2,DYNC1H1,COG2,DYNC1I1,COG5,TMED3,TMEM115,GBF1,DYNC1I2,GOSR2,ARF1,USO1,COG7,DYNLL2,ARF3,GOLGA2,RAB1B,NAPG,BET1L,COPG1,GORASP1,GOSR1,KDELR3,TMED10,SPTBN1,SPTA1,RAB1A
R-HSA-180024	DARPP-32 events	0.0300047592725482	-3.50639926748408	27	27	0.00298870932034536	9034	10285	5144,729966,1020,805,5533,5518,5532,5575,5530,5516,5577,5141,801,5515,5576,808,5568,5143,5534,5499,5519,84152,5142,5566,5528,5573,5567	PDE4D,CIST1,CDK5,CALM2,PPP3CC,PPP2R1A,PPP3CB,PRKAR1B,PPP3CA,PPP2CB,PRKAR2B,PDE4A,CALM1,PPP2CA,PRKAR2A,CALM3,PRKACG,PDE4C,PPP3R1,PPP1CA,PPP2R1B,PPP1R1B,PDE4B,PRKACA,PPP2R5D,PRKAR1A,PRKACB
R-HSA-449147	Signaling by Interleukins	0.0306048914618637	-3.48659543110383	525	475	0.0525791454505203	9034	10285	3687,5525,5715,84292,7529,5608,3574,55540,5970,5526,27178,5921,10392,9965,3569,161742,2247,653604,1234,2261,9846,10197,2676,5923,2903,10817,5724,2263,2675,10538,7316,5159,7431,7132,23118,6464,9180,4170,10156,11009,5704,8315,1956,1839,4609,3662,6288,3934,5690,6712,1742,246778,221002,7409,3568,57162,58480,4318,53832,53833,2266,2248,6809,10718,9466,2906,3815,3554,5711,6097,8826,4684,834,595,6711,2905,10142,3688,409,5595,948,6367,5699,26281,1436,7311,5684,5897,4215,805,4902,1435,153090,57161,152559,8878,5713,10213,54518,5698,356,8452,5979,1026,4747,5008,3560,3586,4763,3567,8767,2249,1850,116379,7850,9462,5922,5747,5906,867,8822,7133,3689,3084,1147,112744,5519,1270,604,2185,53358,5708,115727,3690,6708,283455,5154,10048,2889,7010,50604,596,4985,942,2255,6624,10125,4615,6772,2322,4314,8353,57731,5604,3977,3578,3557,2252,6776,1843,284,4790,3716,7412,3383,2357,7189,3593,5518,5894,5687,8817,6709,133396,6364,801,84868,8355,3265,3627,100500842,7335,5694,8682,5707,23765,1489,6233,2253,5700,3559,3592,9365,2251,28956,25780,1278,4233,5443,3656,84639,408,7291,9021,7124,3596,5720,3636,2244,246,818,2066,51135,3558,3595,54756,3600,3635,2065,8074,27040,100616340,3684,8660,84818,3570,1398,246330,9173,2534,8352,5290,1230,9693,1846,2323,2208,64096,100847012,2919,5682,6356,145957,808,200734,8945,6654,23291,2250,1849,23529,8968,2335,3929,8358,5701,3552,9491,2069,598,126961,7297,3556,5924,2904,6777,2264,5291,5777,3603,3976,8454,5686,54472,6352,56300,2162,3601,10454,5685,3717,1441,3091,1848,7534,5594,5293,5706,8357,4067,29949,5566,673,6885,8649,27177,2668,6351,10818,3572,8350,5292,2308,1271,4988,29760,64926,9978,10256,5295,3576,6714,1326,9655,3932,3575,5296,6778,2353,6810,816,2309,414062,3312,3551,5714,4791,5702,3590,5516,1847,3605,399473,6416,4296,3718,3553,2885,2674,5515,7040,79155,729230,3606,7314,1445,4140,80824,5527,5717,6850,11213,2064,2246,9861,3594,3667,8809,4692,6363,685,836,5692,6710,6347,149233,79923,9235,4893,122706,5710,143471,920,7979,1844,240,88,7157,23198,5536,5696,1439,5623,6500,50616,5743,8503,54014,7334,5695,58985,8831,8354,4313,5908,3845,27179,5786,3588,3320,51332,815,9542,332,64127,1950,5037,5245,8808,3162,301,1901,10148,84078,1052,2625,3911,4312,6095,3726,7422,3562,6774,5605,282616,5718,5528,4254,282618,2260,27006,2243,3082,146433,9048,6348,1437,6597,9244,5451,5896,207,25759,11221,7414,2920,90865,5155,200081,8437,6657,8651,941,5657,6935,10068,6349,5156,5691,8807,3565,163702,5693,817,5719,5529,132014,7525,7450,3587,3566,5781,27189,2254,3674	ITGAX,PPP2R5A,PSMD9,WDR83,YWHAB,MAP2K6,IL7,IL17RB,RELA,PPP2R5B,IL37,RASA1,NOD1,FGF19,IL6,SPRED1,FGF2,H3C13,CCR5,FGFR3,GAB2,PSME3,GFRA3,RASGRF1,GRIN2A,FRS3,PTAFR,FGFR2,GFRA2,BATF,UBC,PDGFRB,VIM,TNFRSF1A,TAB2,SHC1,OSMR,MCL1,RASA4,IL24,PSMC4,BRAP,EGFR,HBEGF,MYC,IRF4,SAA1,LCN2,PSMB2,SPTBN2,DLG4,IL27,RASGEF1A,VAV1,IL5RA,PELI1,RHOU,MMP9,IL20RA,IL20RB,FGG,FGF3,STX3,NRG3,IL27RA,GRIN2D,KIT,IL1R1,PSMD5,RORC,IQGAP1,NCAM1,CASP1,CCND1,SPTBN1,GRIN2C,AKAP9,ITGB1,ARRB2,MAPK3,CD36,CCL22,PSMB10,FGF20,CSF1R,UBA52,PSMA3,RAG2,MAP3K3,CALM2,NRTN,CSF1,DAB2IP,PELI2,PAQR3,SQSTM1,PSMD7,PSMD14,APBB1IP,PSMB9,FASLG,CUL3,RET,CDKN1A,NEFL,OSM,IL2RB,IL10,NF1,IL5,RIPK2,FGF4,DUSP8,IL22RA2,IL1R2,RASAL2,RASA2,PTK2,RAP1A,CBL,FGF17,TNFRSF1B,ITGB2,NRG1,CHUK,IL17F,PPP2R1B,CNTF,BCL6,PTK2B,SHC3,PSMD2,RASGRP4,ITGB3,SPTA1,KSR2,PDGFA,RANBP9,RAPGEF1,TEK,IL20,BCL2,OPRD1,CD86,FGF10,FSCN1,RASGRP1,MYD88,STAT1,FLT3,MMP3,H3C6,SPTBN4,MAP2K1,LIFR,IL9,IL1RN,FGF7,STAT5A,DUSP1,ANGPT1,NFKB1,JAK1,VCAM1,ICAM1,FPR1,TRAF6,IL12B,PPP2R1A,RAF1,PSMA6,FGF18,SPTAN1,IL31RA,CCL20,CALM1,HAVCR2,H3C8,HRAS,CXCL10,MIR3652,UBE2V1,PSMB6,PEA15,PSMD1,IL17RA,CTF1,RPS27A,FGF8,PSMC1,IL2RA,IL12A,KL,FGF6,LAMTOR2,RASGRP3,COL1A2,MET,POMC,IRAK2,IL1F10,ARRB1,TWIST1,SOCS3,TNF,IL13,PSME1,INPPL1,FGB,ALOX15,CAMK2G,ERBB4,IRAK4,IL2,IL12RB2,IL17RD,IL15,INPP5D,ERBB3,FGF23,LAT,MIR4758,ITGAM,IRS2,IL17RC,IL6R,CRK,PELI3,IL1RL1,FYN,H3C3,PIK3CA,CCR1,RAPGEF2,DUSP4,FLT3LG,FCER2,GFRA4,MIR5004,CXCL1,PSMA1,CCL11,NRG4,CALM3,SPRED2,BTRC,SOS1,FBXW11,FGF5,DUSP7,CLCF1,H3C7,FN1,LBP,H3C2,PSMC2,IL1A,PSMF1,EREG,BCL2L1,H3C14,TYK2,IL1RAP,RASGRF2,GRIN2B,STAT5B,FGFR4,PIK3CB,PTPN6,IL16,LIF,CUL1,PSMA5,TOLLIP,CCL5,IL36G,F13A1,IL15RA,TAB1,PSMA4,JAK2,CSF3R,HIF1A,DUSP6,YWHAZ,MAPK1,PIK3CD,PSMC6,H3C10,LYN,IL19,PRKACA,BRAF,MAP3K7,LAMTOR3,IL36B,GDNF,CCL4,FRS2,IL6ST,H3C1,PIM1,FOXO1,CNTFR,OPRM1,BLNK,RASAL3,RBX1,CNKSR1,PIK3R1,CXCL8,SRC,MAP3K8,SOCS5,LCK,IL7R,PIK3R2,STAT6,FOS,STX4,CAMK2B,FOXO3,CCL3L3,HSPA8,IKBKB,PSMD8,NFKB2,PSMC3,IL11RA,PPP2CB,DUSP5,IL17A,SPRED3,MAP2K4,MAP3K11,JAK3,IL1B,GRB2,GFRA1,PPP2CA,TGFB1,TNIP2,CCR2,IL18,UBB,CSK,MARK3,DUSP16,PPP2R5C,PSMD11,SYK,IRAK3,ERBB2,FGF1,PSMD6,IL12RB1,IRS1,IL18R1,NDN,CCL19,BTC,CASP3,PSMB4,SPTB,CCL2,IL23R,NANOG,IL32,NRAS,PSMB11,PSMD4,PSMA8,CD4,SEM1,DUSP2,ALOX5,ACTN2,TP53,PSME4,PPP5C,PSMB8,CSF2RB,PSPN,SKP1,IL22,PTGS2,PIK3R3,BRWD1,UBE2N,PSMB7,IL22RA1,SYNGAP1,H3C11,MMP2,RAP1B,KRAS,IL36A,PTPRA,IL10RB,HSP90AA1,SPTBN5,CAMK2A,NRG2,BIRC5,NOD2,EGF,PEBP1,PHB1,IL1RL2,HMOX1,ANXA1,S1PR1,EBI3,KBTBD7,CEBPD,GATA3,LAMA5,MMP1,RORA,JUNB,VEGFA,IL3,STAT3,MAP2K2,IFNL2,PSMD12,PPP2R5D,KITLG,IFNL1,FGFR1,FGF22,FGA,HGF,IL34,ARTN,CCL3,CSF2,SMARCA4,CRLF1,POU2F1,RAG1,AKT1,SHC2,DUSP10,VCL,CXCL2,IL33,PDGFB,TXLNA,RASAL1,SOX2,SOCS1,CD80,PRTN3,ZEB1,IL18BP,CCL3L1,PDGFRA,PSMB3,IL18RAP,IL4,IFNLR1,PSMB5,CAMK2D,PSMD13,PPP2R5E,IL17RE,YES1,VWF,IL10RA,IL4R,PTPN11,IL17C,FGF9,ITGA2B
R-HSA-397014	Muscle contraction	0.0307359659711435	-3.48232178009009	204	188	0.020810272304627	9034	10285	808,6588,204851,6547,859,10768,444,482,3753,29098,3709,4703,1482,7168,6332,3767,72,3751,29765,3775,2257,30818,4633,4629,4881,10345,7431,3776,7171,6327,100126325,7135,3710,477,4634,28996,4842,7136,30820,9992,6263,55799,59285,93408,6261,478,6335,480,7169,3708,6336,23704,4636,3768,7273,486,779,89822,56660,10174,783,5566,10142,3693,4635,6262,8850,7134,58498,60598,6328,4607,59284,89,805,1760,7220,489,776,25802,6334,53826,29767,784,6329,4882,3784,816,493,54207,9424,3752,2259,4632,481,6331,10368,10008,5829,785,10398,775,4878,2281,4638,6717,7125,3770,6546,4624,29766,10089,781,3777,59,6326,5350,88,7140,50801,2256,483,55800,786,4621,6910,10060,30819,3759,6330,3672,815,27092,56659,7111,8645,84876,491,801,1674,6786,11280,476,302,4604,6323,7170,93589,301,9254,2626,25937,4880,4637,3761,83795,488,10369,10580,59283,5348,53828,8557,27091,140465,80228,100616453,3757,10699,487,4606,6543,7139,7414,818,5349,8291,10627,4626,80333,309,7138,490,800,817,338567,51305,103910	CALM3,SLN,HIPK1,SLC8A3,CAV3,AHCYL1,ASPH,ATP1B2,KCNE1,RANGRF,ITPR2,NEB,NKX2-5,TPM1,SCN7A,KCNJ11,ACTG2,KCND2,TMOD4,KCNK1,FGF12,KCNIP3,MYL2,MYH11,NPR1,TRDN,VIM,KCNK2,TPM4,SCN2B,MIR935,TNNI1,ITPR3,ATP1A2,MYL3,HIPK2,NOS1,TNNI2,KCNIP1,KCNE2,RYR3,CACNA2D3,CACNG6,MYL10,RYR1,ATP1A3,SCN9A,ATP1A4,TPM2,ITPR1,SCN10A,KCNE4,MYL5,KCNJ12,TTN,FXYD2,CACNA1S,KCNK17,KCNK12,SORBS3,CACNB2,PRKACA,AKAP9,ITGB5,MYL4,RYR2,KAT2B,TNNC1,MYL7,KCNK15,SCN3A,MYBPC3,CACNG7,ACTN3,CALM2,DMPK,TRPC1,ATP2A3,CACNA1D,LMOD1,SCN8A,FXYD6,TMOD2,CACNB3,SCN4A,NPR2,KCNQ1,CAMK2B,ATP2B4,KCNK10,KCNK6,KCND3,FGF14,MYL1,ATP1B1,SCN5A,CACNG3,KCNE3,PXN,CACNB4,MYL9,CACNA1C,NPPA,FKBP1B,MYLK,SRI,TNNC2,KCNJ14,SLC8A1,MYH6,TMOD3,KCNK7,CACNA2D1,KCNK3,ACTA2,SCN2A,PLN,ACTN2,TNNT3,KCNK4,FGF11,ATP1B3,SCN3B,CACNG1,MYH3,TBX5,ABCC9,KCNIP2,KCNJ2,SCN4B,ITGA1,CAMK2A,CACNG4,KCNK13,TMOD1,KCNK5,ORAI1,ATP2B2,CALM1,DES,STIM1,SCN11A,ATP1A1,ANXA2,MYBPC1,SCN1A,TPM3,CACNA2D4,ANXA1,CACNA2D2,GATA4,WWTR1,NPPC,MYL6,KCNJ4,KCNK16,ATP2A2,CACNG2,SORBS1,CACNG8,FXYD1,FXYD4,TCAP,CACNG5,MYL6B,ORAI2,MIR4687,KCNH2,CORIN,ATP2A1,MYBPC2,SLC8A2,TNNT2,VCL,CAMK2G,FXYD3,DYSF,MYL12A,MYH8,KCNIP4,ANXA6,TNNT1,ATP2B1,CALD1,CAMK2D,KCNK18,KCNK9,MYL12B
R-HSA-189200	Hexose transport	0.0323255861284136	-3.43189622213242	54	52	0.00575603276510959	9034	10285	53371,6513,23225,9972,92579,100101267,23165,5903,23511,26291,23279,6518,3101,11097,55706,9688,125206,9818,6248,3098,79023,144195,6517,6515,200010,79902,2646,55746,57122,6527,10762,23636,55974,348995,2645,57818,3099,2542,6526,81929,9631,6514,8086,85414,7175,4928,129401,6523,4927,9883,2538,8021	NUP54,SLC2A1,NUP210,NUP153,G6PC3,POM121C,NUP205,RANBP2,NUP188,FGF21,NUP160,SLC2A5,HK3,NUP42,NDC1,NUP93,SLC5A10,NUP58,RSC1A1,HK1,NUP37,SLC2A14,SLC2A4,SLC2A3,SLC5A9,NUP85,GCKR,NUP133,NUP107,SLC5A4,NUP50,NUP62,SLC50A1,NUP43,GCK,G6PC2,HK2,SLC37A4,SLC5A3,SEH1L,NUP155,SLC2A2,AAAS,SLC45A3,TPR,NUP98,NUP35,SLC5A1,NUP88,POM121,G6PC1,NUP214
R-HSA-418594	G alpha (i) signalling events	0.032870822709224	-3.41516986243688	242	222	0.0245738321895063	9034	10285	4889,8698,6751,54331,109,259285,339403,113,50838,117579,2782,10316,2357,51289,6753,2847,3355,54429,10681,6364,3827,1902,10563,2826,50835,2790,2786,3352,9934,2917,338398,115,9568,6754,26166,5733,6363,256933,727,4985,3579,165140,6002,611,114,4986,406974,728,1237,5999,2784,2920,6755,64805,50865,3577,10692,346562,6001,94235,64407,259289,6003,9290,50837,10874,2358,5173,1230,3351,4544,129521,8787,23596,2919,3627,1901,51083,301,2773,259286,2918,259290,27199,56670,196883,2781,4543,259287,2359,6370,3354,431704,2783,7852,4887,1903,11251,718,6366,5443,56923,6387,50834,6752,2771,3361,2792,624,3350,6374,2832,5697,107,55970,57007,5196,6352,4852,6000,6288,11255,2921,9628,2550,108,353299,643,187,1233,59345,2912,50832,2770,259294,9294,623,84539,8490,1815,56477,2787,50839,1234,23566,2916,4987,5368,2780,846,5996,151,259295,5540,6373,112,6368,5995,1132,2852,111,1235,2779,8484,3576,10663,2914,1814,1236,85397,152,1325,57121,53829,6372,5726,59340,2587,338442,1129,134,221391,8786,51764,259292,1269,729230,6010,10803,259296,8811,6750,2841,53637,50833,183,2788,2793,8601,719,10636,6360,1268,10022,4886,58191,5539,140,351,10850,2778,2831,1232,2913,1813,10287,150,5367,4988,5179,50831,2791	NPY5R,S1PR4,SSTR1,GNG2,ADCY3,TAS2R39,RXFP4,ADCY7,TAS2R13,RLN3,GNB1,NMUR1,FPR1,RXFP3,SSTR3,MCHR1,HTR1F,TAS2R5,GNB5,CCL20,KNG1,LPAR1,CXCL13,CCR10,TAS2R9,GNG10,GNG4,HTR1D,P2RY14,GRM7,TAS2R60,ADCY9,GABBR2,SSTR4,RGS22,PTGER3,CCL19,NPB,C5,OPRD1,CXCR2,OXER1,RGS12,OPN1SW,ADCY8,OPRK1,MIR197,C5AR1,CCR8,RGS4,GNB3,CXCL2,SSTR5,P2RY12,HEBP1,CXCR1,RRH,GNAT3,RGS10,GNG8,RGS18,TAS2R43,RGS13,GPR55,TAS2R7,NMU,FPR2,PDYN,CCR1,HTR1B,MTNR1B,NMS,RGS9,OPN3,CXCL1,CXCL10,S1PR1,GAL,ANXA1,GNAI3,TAS2R40,GRM8,TAS2R31,OXGR1,SUCNR1,ADCY4,GNAZ,MTNR1A,TAS2R41,FPR3,CCL25,HTR1E,RGS21,GNB2,CXCR4,NPY2R,S1PR3,PTGDR2,C3,CCL21,POMC,NMUR2,CXCL12,TAS2R1,SSTR2,GNAI2,HTR5A,GNGT1,BDKRB2,HTR1A,CXCL5,NPBWR2,PYY,ADCY1,GNG12,ACKR3,PF4,CCL5,NPY,RGS7,SAA1,HRH3,CXCL3,RGS6,GABBR1,ADCY2,RGSL1,CXCR5,APLNR,CCR4,GNB4,GRM2,TAS2R4,GNAI1,TAS2R19,S1PR2,BDKRB1,MCHR2,RGS5,DRD4,CCL28,GNG5,TAS2R10,CCR5,LPAR3,GRM6,OPRL1,PNOC,GNAT2,CASR,RGS1,ADRA2B,TAS2R20,NPY4R,CXCL11,ADCY6,CCL23,RGR,CHRM4,GPER1,ADCY5,CCR6,GNAT1,GALR3,CXCL8,CXCR6,GRM4,DRD3,CCR7,RGS8,ADRA2C,CORT,LPAR5,P2RY13,CXCL6,TAS2R38,HRH4,GALR1,HCAR2,CHRM2,ADORA1,OPN5,RGS11,GNG13,TAS2R46,CNR2,CCR2,RHO,CCR9,TAS2R50,GALR2,SST,GPR18,S1PR5,TAS2R16,AGT,GNG7,GNGT2,RGS20,C3AR1,RGS14,CCL16,CNR1,INSL5,NPY1R,CXCL16,PPY,ADORA3,APP,CCL27,GNAS,NPBWR1,CCR3,GRM3,DRD2,RGS19,ADRA2A,PMCH,OPRM1,PENK,TAS2R3,GNG11
R-HSA-5683057	MAPK family signaling cascades	0.0331360566051257	-3.40713326606366	290	265	0.0293336285145008	9034	10285	4343,4902,5596,8997,2308,153090,64926,9978,8556,152559,10256,5713,10818,5595,3572,5699,26281,7311,3315,5684,5897,896,805,8555,8826,673,4684,8649,6711,989,2905,2668,10142,409,5706,2266,2248,10718,5566,2906,3815,5711,8822,5515,7314,1445,4140,10642,80824,5702,5516,1847,4763,3567,399473,2249,1850,9462,4296,5922,3718,5747,2885,2674,5906,4747,3560,816,2309,27161,5714,10213,6714,54518,5698,8452,5979,2675,7297,5159,7316,2676,10197,9491,5923,2903,10817,2069,2263,998,5526,6654,5921,10435,2250,1849,9965,3569,161742,2247,2335,2261,5701,5682,5525,5715,84292,7529,145957,808,200734,3337,5685,3717,221002,1848,3568,5594,5686,5690,57690,6712,1742,8315,26523,1956,1839,4609,5924,6464,2904,27327,2264,10156,5704,4233,9048,1437,408,5896,5700,4254,3559,5597,2260,192670,27006,9365,2243,2251,25780,28956,3082,5707,5058,3562,5567,6233,5605,2253,5528,5718,3725,3265,84078,5694,8682,5529,5719,1846,9693,7450,5781,2254,64096,100847012,3674,8202,3570,2118,5693,2534,817,54756,5156,2065,27040,7514,8074,5691,8660,5720,25759,11221,2244,7414,2066,818,5155,3558,5062,8437,5710,143471,10125,7979,192669,1844,88,23198,5692,2255,6710,4893,122706,3667,10602,3690,6708,283455,10048,5154,685,7010,3084,5527,5717,5519,2064,2246,9861,5568,53358,5708,115727,5894,5687,8817,9542,1950,6709,5037,801,5245,3716,5908,3845,5786,983,815,51332,5518,2252,5695,1843,284,8831,23112,5879,5536,5696,57731,1439,5623,5604	MOV10,NRTN,MAPK4,KALRN,FOXO1,DAB2IP,RASAL3,RBX1,CDC14A,PAQR3,CNKSR1,PSMD7,FRS2,MAPK3,IL6ST,PSMB10,FGF20,UBA52,HSPB1,PSMA3,RAG2,CCND3,CALM2,CDC14B,IQGAP1,BRAF,NCAM1,LAMTOR3,SPTBN1,SEPTIN7,GRIN2C,GDNF,AKAP9,ARRB2,PSMC6,FGG,FGF3,NRG3,PRKACA,GRIN2D,KIT,PSMD5,FGF17,PPP2CA,UBB,CSK,MARK3,IGF2BP1,DUSP16,PSMC3,PPP2CB,DUSP5,NF1,IL5,SPRED3,FGF4,DUSP8,RASAL2,MAP3K11,RASA2,JAK3,PTK2,GRB2,GFRA1,RAP1A,NEFL,IL2RB,CAMK2B,FOXO3,AGO2,PSMD8,PSMD14,SRC,APBB1IP,PSMB9,CUL3,RET,GFRA2,TYK2,PDGFRB,UBC,GFRA3,PSME3,PSMF1,RASGRF1,GRIN2A,FRS3,EREG,FGFR2,CDC42,PPP2R5B,SOS1,RASA1,CDC42EP2,FGF5,DUSP7,FGF19,IL6,SPRED1,FGF2,FN1,FGFR3,PSMC2,PSMA1,PPP2R5A,PSMD9,WDR83,YWHAB,NRG4,CALM3,SPRED2,DNAJB1,PSMA4,JAK2,RASGEF1A,DUSP6,IL5RA,MAPK1,PSMA5,PSMB2,TNRC6C,SPTBN2,DLG4,BRAP,AGO1,EGFR,HBEGF,MYC,RASGRF2,SHC1,GRIN2B,TNRC6A,FGFR4,RASA4,PSMC4,MET,ARTN,CSF2,ARRB1,RAG1,PSMC1,KITLG,IL2RA,MAPK6,FGFR1,AGO4,FGF22,KL,FGA,FGF6,RASGRP3,LAMTOR2,HGF,PSMD1,PAK1,IL3,PRKACB,RPS27A,MAP2K2,FGF8,PPP2R5D,PSMD12,JUN,HRAS,KBTBD7,PSMB6,PEA15,PPP2R5E,PSMD13,DUSP4,RAPGEF2,VWF,PTPN11,FGF9,GFRA4,MIR5004,ITGA2B,NCOA3,IL6R,ETV4,PSMB5,FYN,CAMK2D,IL17RD,PDGFRA,ERBB3,LAT,XPO1,FGF23,PSMB3,IRS2,PSME1,SHC2,DUSP10,FGB,VCL,ERBB4,CAMK2G,PDGFB,IL2,PAK2,RASAL1,PSMD4,PSMA8,RASGRP1,SEM1,AGO3,DUSP2,ACTN2,PSME4,PSMB4,FGF10,SPTB,NRAS,PSMB11,IRS1,CDC42EP3,ITGB3,SPTA1,KSR2,RANBP9,PDGFA,BTC,TEK,NRG1,PPP2R5C,PSMD11,PPP2R1B,ERBB2,FGF1,PSMD6,PRKACG,SHC3,PSMD2,RASGRP4,RAF1,PSMA6,FGF18,NRG2,EGF,SPTAN1,PEBP1,CALM1,PHB1,JAK1,RAP1B,KRAS,PTPRA,CDK1,CAMK2A,SPTBN5,PPP2R1A,FGF7,PSMB7,DUSP1,ANGPT1,SYNGAP1,TNRC6B,RAC1,PPP5C,PSMB8,SPTBN4,CSF2RB,PSPN,MAP2K1
R-HSA-2029485	Role of phospholipids in phagocytosis	0.0341717168496108	-3.37635696976213	26	26	0.00287801638255479	9034	10285	10768,122618,8398,5296,3709,2209,5581,5291,196051,5295,3710,2212,6850,5335,3708,919,917,5337,5290,5580,9103,2214,5336,23646,5338,84513	AHCYL1,PLD4,PLA2G6,PIK3R2,ITPR2,FCGR1A,PRKCE,PIK3CB,PLPP4,PIK3R1,ITPR3,FCGR2A,SYK,PLCG1,ITPR1,CD247,CD3G,PLD1,PIK3CA,PRKCD,FCGR2C,FCGR3A,PLCG2,PLD3,PLD2,PLPP5
R-HSA-975576	N-glycan antennae elongation in the medial/trans-Golgi	0.0341717168496108	-3.37635696976213	26	26	0.00287801638255479	9034	10285	4248,9486,2517,1081,6484,338596,11320,4124,2530,4247,8704,3972,6480,9334,8128,51046,4249,25834,8702,9331,11282,2683,64377,4122,2525,8703	MGAT3,CHST10,FUCA1,CGA,ST3GAL4,ST8SIA6,MGAT4A,MAN2A1,FUT8,MGAT2,B4GALT2,LHB,ST6GAL1,B4GALT5,ST8SIA2,ST8SIA3,MGAT5,MGAT4C,B4GALT4,B4GALT6,MGAT4B,B4GALT1,CHST8,MAN2A2,FUT3,B4GALT3
R-HSA-422475	Axon guidance	0.0344858190090177	-3.36720708266312	549	496	0.0549036971441222	9034	10285	2243,27006,4254,23122,2260,10487,3082,3791,9048,7903,1437,57556,5664,7430,51466,84078,23396,8633,6453,7422,10552,5605,3562,5058,5217,5528,5718,4637,26052,56896,6092,287,1020,817,1211,5693,90249,7450,7525,103910,102,5719,5529,64218,5781,3674,2254,10627,25759,11221,1457,8437,7414,23129,5155,5362,6900,56963,10093,2932,1213,5156,25,5691,5692,10092,122706,8851,4893,9252,84448,6710,7204,5361,1459,143471,5710,23198,5598,88,7979,6456,1844,1808,2064,5717,5527,3685,64283,1072,5909,2246,10398,9861,10752,1212,3667,8828,685,3915,6091,5786,3845,5908,3320,815,51332,3912,55816,2242,2909,1809,22885,285220,8829,9542,5245,285643,5621,1950,5037,5696,55800,1439,5536,160,5623,5695,8503,5879,2050,4313,8831,1385,7220,10818,6328,1298,3984,10097,9423,9978,10256,214,7305,64926,8986,5566,5706,4067,779,2549,8649,673,2668,2817,1847,399473,5702,5516,2043,3718,23385,4296,2674,2885,6331,7314,387,5515,80824,1445,4140,6329,6714,1299,5295,131873,23332,784,1284,1943,286,5296,5714,3312,816,7410,9491,2042,6237,2069,6327,1297,220164,3785,1942,145957,5682,1969,200734,808,1849,6332,2250,3786,6654,6461,5701,5588,2335,1946,6335,59277,5686,9901,8482,6336,3717,5685,5594,5293,5335,1848,5962,2904,1272,5924,2046,2264,5291,2045,1739,9365,7074,3559,5700,2049,9475,25780,28956,2251,1796,4233,8440,408,5880,1949,3265,148738,10154,6586,8682,1293,6323,5694,7225,6233,5567,5707,8912,6585,3673,2253,91584,7222,2887,1948,2534,9693,1846,389,5290,27255,4756,8874,100847012,64096,288,2244,5720,3558,5062,2048,1463,818,2066,57522,1759,54756,8660,9260,161,27040,8074,2065,6326,2255,10096,27,7223,10125,971,10507,3084,5519,9826,5708,775,115727,27289,53358,5568,6708,3690,10048,5154,283455,10109,7010,1793,9037,5364,23365,3716,8911,5518,10451,11280,5894,8817,57144,5687,801,8515,6709,57731,116986,284656,5604,3672,2252,6330,2047,8913,284,5306,1843,5699,26281,7311,71,6386,5595,8976,5684,9353,805,6477,1944,1400,153090,4902,8997,152559,1175,5713,6334,776,2248,10718,375790,1785,8218,5216,2266,783,2044,60,3815,55740,5711,56924,2906,6711,4897,8826,4684,25791,409,3688,10142,2905,23114,4763,3567,10094,2051,57698,5922,5906,5747,1850,2249,9462,5788,284217,8822,785,79784,8128,10213,6655,5979,8452,5698,4627,54518,2596,3983,3560,51107,80031,4747,388,64221,10095,10371,2903,2676,10197,5923,2263,998,10817,6478,391,3680,2675,10486,5578,4629,5159,9046,7316,84292,7529,83464,1286,1173,5715,5525,6383,285704,9965,5526,5921,1285,219699,2261,9846,2247,161742,57113,7408,5690,4651,1282,1630,6712,3985,1742,8650,23380,256076,28964,221002,4318,163,3568,55715,6464,6196,10156,3326,5704,137970,4628,11313,8315,6195,9723,1839,1956,4690,10298	FGA,FGF22,KITLG,CLASP2,FGFR1,CAP1,HGF,KDR,ARTN,ST8SIA4,CSF2,SEMA6A,PSEN2,EZR,EVL,KBTBD7,PIP5K1C,UNC5C,ITSN1,VEGFA,ARPC1A,MAP2K2,IL3,PAK1,PFN2,PPP2R5D,PSMD12,MYL6,DNM3,DPYSL5,ROBO2,ANK2,CDK5,CAMK2D,CLTA,PSMB5,UNC5A,VWF,YES1,MYL12B,ADAM10,PSMD13,PPP2R5E,SEMA4A,PTPN11,ITGA2B,FGF9,MYL12A,SHC2,DUSP10,CSNK2A1,RASAL1,VCL,PLXND1,PDGFB,PLXNA2,CNTN2,RGMA,ARPC4,GSK3B,CLTC,PDGFRA,ABL1,PSMB3,PSMB4,ARPC5,PSMB11,CDK5R1,NRAS,RPS6KA5,ABLIM2,SPTB,TRIO,PLXNA1,CSNK2A2,PSMA8,PSMD4,PSME4,MAPK7,ACTN2,SEM1,SH3GL2,DUSP2,DPYSL2,ERBB2,PSMD11,PPP2R5C,ITGAV,ARHGEF28,CFL1,RAP1GAP,FGF1,MYL9,PSMD6,CHL1,CLTB,IRS1,NRP2,BTC,LAMC1,ROBO1,PTPRA,KRAS,RAP1B,HSP90AA1,CAMK2A,SPTBN5,LAMB1,DOK5,FES,ARHGAP35,DPYSL3,ABLIM3,EPHA6,NRP1,NRG2,PHB1,KIF4B,PRNP,EGF,PEBP1,PSMB8,SCN3B,CSF2RB,PPP5C,AP2A1,PSPN,PSMB7,PIK3R3,RAC1,EPHB4,MMP2,SYNGAP1,CREB1,TRPC1,FRS2,SCN3A,COL9A2,LIMK1,ACTR2,NTN1,RBX1,CNKSR1,ALCAM,TYROBP,RASAL3,RPS6KA4,PRKACA,PSMC6,LYN,CACNA1S,GAB1,LAMTOR3,BRAF,GDNF,GPC1,DUSP5,SPRED3,PSMC3,PPP2CB,EPHA4,JAK3,NCSTN,MAP3K11,GFRA1,GRB2,SCN5A,UBB,RHOA,PPP2CA,DUSP16,CSK,MARK3,SCN4A,SRC,COL9A3,PIK3R1,COL6A6,CLASP1,CACNB3,COL4A2,EFNA2,ANK1,PIK3R2,PSMD8,HSPA8,CAMK2B,VAV2,PSMF1,EPHA3,RRAS,EREG,SCN2B,COL9A1,DOK6,KCNQ2,EFNA1,NRG4,PSMA1,EPHA2,SPRED2,CALM3,DUSP7,SCN7A,FGF5,KCNQ3,SOS1,SHB,PSMC2,PRKCQ,FN1,EFNA5,SCN9A,NTN4,PSMA5,SRGAP3,SEMA7A,SCN10A,JAK2,PSMA4,MAPK1,PIK3CD,PLCG1,DUSP6,RDX,GRIN2B,CNTN1,RASGRF2,EPHA8,FGFR4,PIK3CB,EPHA7,DLG1,KL,TIAM1,IL2RA,PSMC1,EPHB3,ROCK2,RASGRP3,LAMTOR2,FGF6,DOK1,MET,NCK2,ARRB1,RAC2,EFNB3,HRAS,HJV,PLXNC1,SLIT3,PEA15,COL6A3,SCN1A,PSMB6,TRPC6,RPS27A,PRKACB,PSMD1,CACNA1H,SLIT1,ITGA2,FGF8,PLXNA4,TRPC3,GRB10,EFNB2,FYN,RAPGEF2,DUSP4,RHOC,PIK3CA,CNTN6,NEO1,ARHGEF7,MIR5004,GFRA4,ANK3,FGB,PSME1,IL2,PAK2,EPHB2,NCAN,CAMK2G,ERBB4,SRGAP1,DNM1,IL17RD,IRS2,PDLIM7,AP2A2,LAT,FGF23,ERBB3,SCN2A,FGF10,ACTR3,ABL2,TRPC4,RASGRP1,CD72,SEMA4D,NRG1,PPP2R1B,ARHGEF11,PSMD2,CACNA1C,RASGRP4,RND1,SHC3,PRKACG,SPTA1,ITGB3,RANBP9,PDGFA,KSR2,ARPC2,TEK,DOCK1,SEMA5A,PLXNB1,ARHGEF12,JAK1,CACNA1I,PPP2R1A,VAV3,SCN11A,RAF1,FGF18,PAK5,PSMA6,CALM1,ITGA10,SPTAN1,SPTBN4,AGAP2,EPHA10,MAP2K1,ITGA1,FGF7,SCN4B,EPHB1,CACNA1G,ANGPT1,PITPNA,DUSP1,PSMB10,FGF20,UBA52,ACTG1,SDCBP,MAPK3,WASL,PSMA3,SLIT2,CALM2,SIAH1,EFNA3,CRMP1,DAB2IP,NRTN,KALRN,PAQR3,AP2S1,PSMD7,SCN8A,CACNA1D,FGF3,NRG3,AGRN,DNM2,CLTCL1,PFN1,FGG,CACNB2,EPHA5,ACTB,KIT,ENAH,PSMD5,PAK6,GRIN2D,SPTBN1,NRCAM,IQGAP1,NCAM1,NGEF,ARRB2,ITGB1,AKAP9,GRIN2C,NFASC,NF1,IL5,ARPC3,EPHB6,SHTN1,RASA2,RAP1A,PTK2,DUSP8,FGF4,RASAL2,PTPRC,LAMA1,FGF17,CACNB4,MYH14,ST8SIA2,PSMD14,SOS2,RET,CUL3,PSMB9,MYH9,APBB1IP,GAP43,ABLIM1,IL2RB,APH1A,SEMA6D,NEFL,RHOB,ROBO3,ARPC1B,SEMA3A,GRIN2A,GFRA3,PSME3,RASGRF1,FGFR2,CDC42,FRS3,SIAH2,RHOG,ITGA9,GFRA2,CAP2,PRKCA,MYH11,PDGFRB,DOK2,UBC,WDR83,YWHAB,APH1B,COL4A4,AP2M1,PSMD9,PPP2R5A,SDC2,RGMB,FGF19,PPP2R5B,RASA1,COL4A3,UNC5B,FGFR3,GAB2,FGF2,SPRED1,TRPC7,VASP,PSMB2,MYO10,COL4A1,DCC,SPTBN2,LIMK2,DLG4,NUMB,SRGAP2,COL6A5,GIT1,RASGEF1A,MMP9,AP2B1,IL5RA,DOK4,SHC1,RPS6KA2,RASA4,HSP90AB1,PSMC4,UNC5D,MYH10,LYPLA2,BRAP,RPS6KA1,SEMA3E,HBEGF,EGFR,NCK1,PAK4
R-HSA-8856688	Golgi-to-ER retrograde transport	0.0344944186099994	-3.36695774745283	110	103	0.0114013725924286	9034	10285	29127,81876,8729,140735,81930,375,636,51594,147700,23046,3833,5870,8398,547,11015,9585,51164,381,11316,5321,3831,1639,10749,51014,60561,5048,372,55614,23423,22931,23095,1780,23303,3798,23299,662,5049,4905,9276,64837,9183,55605,56992,10112,10945,55582,10540,3799,63908,64147,9554,10671,11004,22930,2590,26153,3834,53407,51226,22820,8774,1781,377,5861,10972,9493,2589,89953,22920,3797,124602,3835,56894,378,1315,51560,221458,3796,25782,1783,1062,1778,26958,84643,6836,51143,146909,84516,3832,11014,8655,54732,11127,26286,55738,55083,11258,113220,55850,84364,10959,285643,22818	RACGAP1,RAB1B,GBF1,DYNLL2,KIF18A,ARF1,BICD1,NBAS,KLC3,KIF21B,KIFC1,RAB6A,PLA2G6,KIF1A,KDELR3,KIF20B,DCTN4,ARF5,COPE,PLA2G4A,KLC1,DCTN1,KIF1C,TMED7,RINT1,PAFAH1B1,ARCN1,KIF16B,TMED3,RAB18,KIF1B,DYNC1I1,KIF13B,KIF5A,BICD2,BNIP1,PAFAH1B2,NSF,COPB2,KLC2,ZW10,KIF21A,KIF15,KIF20A,KDELR1,KIF27,DCTN2,KIF5B,NAPB,KIF9,SEC22B,DCTN6,KIF2C,RAB3GAP1,GALNT2,KIF26A,KIF25,STX18,COPZ2,COPG1,NAPG,DYNC1I2,ARF3,RAB1A,TMED10,KIF23,GALNT1,KLC4,KIFAP3,KIF3C,KIF19,KIF22,AGPAT3,ARF4,COPB1,RAB6B,KIF6,KIF2A,RAB3GAP2,DYNC1LI2,CENPE,DYNC1H1,COPG2,KIF2B,SURF4,DYNC1LI1,KIF18B,DCTN5,KIF11,KDELR2,DYNLL1,TMED9,KIF3A,ARFGAP3,ARFGAP1,KIF26B,DCTN3,KIF12,USE1,ARFGAP2,TMED2,KIF4B,COPZ1
R-HSA-913531	Interferon Signaling	0.0362110248829855	-3.3183916517392	201	185	0.0204781934912553	9034	10285	3117,4938,1981,5770,3662,25820,25939,5300,5335,3445,2633,9818,8554,3717,3133,23279,23511,5903,3455,4261,115361,85363,3456,3840,23225,5777,81603,3659,8021,9883,5724,23650,4502,3837,80263,3394,163351,7316,6672,3452,9631,5610,7297,2537,3442,388646,4939,5371,7324,57122,2634,3665,3134,1974,3434,10107,55223,3107,117854,3441,55706,3118,7314,3135,10581,3664,100101267,23165,23321,2635,3443,3460,100500827,816,3136,3839,51447,3120,9636,3663,10612,960,5595,3444,6041,103,7311,115362,2317,6737,7175,10410,129401,5495,3838,8638,5580,8519,10379,4940,3433,10437,3119,4600,3127,9470,3661,1982,3454,79902,3429,4684,815,4599,3716,7412,3383,567,9830,9246,11097,7706,23087,7341,3440,9775,4734,51191,5696,9972,80128,402569,7334,3660,684,3123,6772,4928,3836,3437,8086,54739,23636,10762,55746,7726,3106,3122,817,79023,3448,3669,5781,3105,9688,55128,6773,1977,818,3439,2210,5771,3458,11074,53371,8651,1958,3113,10475,8672,4927,317649,100847079,9021,3459,81929,7318,348995,3449,53840,91543,23586,2209,693215,6233	HLA-DQA1,OAS1,EIF4G1,PTPN1,IRF4,ARIH1,SAMHD1,PIN1,PLCG1,IFNA8,GBP1,NUP58,PIAS1,JAK2,HLA-E,NUP160,NUP188,RANBP2,IFNAR2,CIITA,GBP4,TRIM5,IFNB1,KPNA4,NUP210,PTPN6,TRIM8,IRF1,NUP214,POM121,PTAFR,TRIM29,MT2A,KPNB1,TRIM45,IRF8,GBP6,UBC,SP100,IFNA21,NUP155,EIF2AK2,TYK2,IFI6,IFNA5,GBP7,OAS2,PML,UBE2E1,NUP107,GBP2,IRF7,HLA-F,EIF4A2,IFIT1,TRIM10,TRIM62,HLA-C,TRIM6,IFNA4,NDC1,HLA-DQA2,UBB,HLA-G,IFITM2,IRF6,POM121C,NUP205,TRIM2,GBP3,IFNA6,IFNGR2,MIR3614,CAMK2B,HLA-H,KPNA3,IP6K2,HLA-DQB2,ISG15,IRF5,TRIM3,CD44,MAPK3,IFNA7,RNASEL,ADAR,UBA52,GBP5,FLNB,TRIM21,TPR,IFITM3,NUP35,PPM1B,KPNA2,OASL,PRKCD,IFITM1,IRF9,OAS3,IFIT2,IFI30,HLA-DQB1,MX2,HLA-DRB5,EIF4E2,IRF3,EIF4G2,IFNAR1,NUP85,IFI27,NCAM1,CAMK2A,MX1,JAK1,VCAM1,ICAM1,B2M,TRIM14,UBE2L6,NUP42,TRIM25,TRIM35,SUMO1,IFNA2,EIF4A3,NEDD4,HERC5,PSMB8,NUP153,TRIM46,KPNA7,UBE2N,IRF2,BST2,HLA-DRB1,STAT1,NUP98,KPNA1,IFIT3,AAAS,XAF1,NUP62,NUP50,NUP133,TRIM26,HLA-B,HLA-DRA,CAMK2D,NUP37,IFNA14,ISG20,PTPN11,HLA-A,NUP93,TRIM68,STAT2,EIF4E,CAMK2G,IFNA1,FCGR1BP,PTPN2,IFNG,TRIM31,NUP54,SOCS1,EGR1,HLA-DPA1,TRIM38,EIF4G3,NUP88,EIF4E3,MIR5193,SOCS3,IFNGR1,SEH1L,UBA7,NUP43,IFNA16,TRIM34,RSAD2,RIGI,FCGR1A,MIR630,RPS27A
R-HSA-991365	Activation of GABAB receptors	0.0362715879656244	-3.31672054485293	40	39	0.00431702457383219	9034	10285	111,2790,3766,2770,2792,2786,2788,2784,2773,2793,3768,54331,3765,9568,115,109,107,3759,2787,55970,346562,3772,3773,196883,3761,94235,3760,3762,113,2782,2783,2774,3763,114,112,2550,108,406974,2771	ADCY5,GNG10,KCNJ10,GNAI1,GNGT1,GNG4,GNG7,GNB3,GNAI3,GNGT2,KCNJ12,GNG2,KCNJ9,GABBR2,ADCY9,ADCY3,ADCY1,KCNJ2,GNG5,GNG12,GNAT3,KCNJ15,KCNJ16,ADCY4,KCNJ4,GNG8,KCNJ3,KCNJ5,ADCY7,GNB1,GNB2,GNAL,KCNJ6,ADCY8,ADCY6,GABBR1,ADCY2,MIR197,GNAI2
R-HSA-1442490	Collagen degradation	0.0362715879656244	-3.31672054485293	40	39	0.00431702457383219	9034	10285	4318,4314,9313,1513,1305,1307,5045,1297,102,4316,164656,4323,1298,1306,1308,1509,4317,4320,85007,4322,4321,4313,6868,1514,1310,4312,4319,4327,91522,136227,4324,84570,1508,100126326,1303,1991,7373,1299,8754	MMP9,MMP3,MMP20,CTSK,COL13A1,COL16A1,FURIN,COL9A1,ADAM10,MMP7,TMPRSS6,MMP14,COL9A2,COL15A1,COL17A1,CTSD,MMP8,MMP11,PHYKPL,MMP13,MMP12,MMP2,ADAM17,CTSL,COL19A1,MMP1,MMP10,MMP19,COL23A1,COL26A1,MMP15,COL25A1,CTSB,MIR936,COL12A1,ELANE,COL14A1,COL9A3,ADAM9
R-HSA-109703	PKB-mediated events	0.0362715879656244	-3.31672054485293	40	39	0.00431702457383219	9034	10285	29904,7529,207,51719,5140,81617,6198,6194,1977,10542,5564,57521,1975,8649,7248,2475,6794,1978,5565,389541,55437,84335,5562,1981,64121,208,6009,51422,53632,5494,64223,5571,28956,5563,58528,55004,7249,92335,10670	EEF2K,YWHAB,AKT1,CAB39,PDE3B,CAB39L,RPS6KB1,RPS6,EIF4E,LAMTOR5,PRKAB1,RPTOR,EIF4B,LAMTOR3,TSC1,MTOR,STK11,EIF4EBP1,PRKAB2,LAMTOR4,STRADB,AKT1S1,PRKAA1,EIF4G1,RRAGC,AKT2,RHEB,PRKAG2,PRKAG3,PPM1A,MLST8,PRKAG1,LAMTOR2,PRKAA2,RRAGD,LAMTOR1,TSC2,STRADA,RRAGA
R-HSA-977444	GABA B receptor activation	0.0362715879656244	-3.31672054485293	40	39	0.00431702457383219	9034	10285	406974,2771,2550,112,108,2783,114,2774,3763,113,3762,3760,2782,196883,3773,3761,94235,107,109,9568,115,3765,54331,3772,346562,2787,3759,55970,2784,2788,3768,2773,2793,2792,2770,3766,2790,111,2786	MIR197,GNAI2,GABBR1,ADCY6,ADCY2,GNB2,ADCY8,GNAL,KCNJ6,ADCY7,KCNJ5,KCNJ3,GNB1,ADCY4,KCNJ16,KCNJ4,GNG8,ADCY1,ADCY3,GABBR2,ADCY9,KCNJ9,GNG2,KCNJ15,GNAT3,GNG5,KCNJ2,GNG12,GNB3,GNG7,KCNJ12,GNAI3,GNGT2,GNGT1,GNAI1,KCNJ10,GNG10,ADCY5,GNG4
R-HSA-5218921	VEGFR2 mediated cell proliferation	0.0386799786535187	-3.25243316027106	258	236	0.0261235333185743	9034	10285	2885,5906,2674,5747,5922,3718,4296,9462,1850,2249,399473,3567,1847,4763,5516,5702,80824,4140,1445,7314,8822,5515,5979,8452,5698,54518,6714,10213,5714,816,3560,4747,805,5684,7311,5699,26281,5595,10818,5713,10256,152559,9978,64926,153090,5580,4902,5711,3815,2906,10718,2248,2266,5706,409,10142,2668,2905,6711,8649,4684,673,8826,1742,6712,5690,5686,5335,3708,5594,5170,3568,1848,221002,3717,5685,5704,10156,2264,2904,5924,6464,3710,1839,1956,5579,8315,2263,2069,10817,2903,5923,8877,9491,10197,2676,5578,5159,7316,2675,200734,808,7529,145957,84292,5715,5525,5682,5701,2261,2335,161742,2247,10768,9965,2250,1849,5921,6654,3709,5526,817,5693,2534,3674,100847012,2254,64096,7450,9693,1846,5719,5529,8437,3558,5155,818,2066,7414,11221,2244,25759,5720,8660,8074,5691,27040,2065,5156,54756,3082,3791,2251,28956,25780,2243,9365,27006,2260,4254,3559,5700,408,1437,9048,4233,8682,5694,84078,3265,5528,5718,2253,5605,6233,3562,7422,5590,5707,5518,815,51332,5786,3845,5908,3716,5245,801,5037,6709,1950,9542,8817,5687,5894,5604,5623,1439,57731,5696,5536,8831,284,1843,5695,2252,4893,122706,6710,2255,5692,23198,88,1844,7979,10125,143471,5710,115727,5708,53358,9861,2246,2064,5519,5527,5717,3084,7010,685,5154,10048,283455,6708,3690,3667	GRB2,RAP1A,GFRA1,PTK2,RASA2,JAK3,MAP3K11,RASAL2,DUSP8,FGF4,SPRED3,IL5,DUSP5,NF1,PPP2CB,PSMC3,DUSP16,MARK3,CSK,UBB,FGF17,PPP2CA,RET,CUL3,PSMB9,APBB1IP,SRC,PSMD14,PSMD8,CAMK2B,IL2RB,NEFL,CALM2,PSMA3,UBA52,PSMB10,FGF20,MAPK3,FRS2,PSMD7,CNKSR1,PAQR3,RBX1,RASAL3,DAB2IP,PRKCD,NRTN,PSMD5,KIT,GRIN2D,NRG3,FGF3,FGG,PSMC6,ARRB2,AKAP9,GDNF,GRIN2C,SPTBN1,LAMTOR3,NCAM1,BRAF,IQGAP1,DLG4,SPTBN2,PSMB2,PSMA5,PLCG1,ITPR1,MAPK1,PDPK1,IL5RA,DUSP6,RASGEF1A,JAK2,PSMA4,PSMC4,RASA4,FGFR4,GRIN2B,RASGRF2,SHC1,ITPR3,HBEGF,EGFR,PRKCB,BRAP,FGFR2,EREG,FRS3,GRIN2A,RASGRF1,SPHK1,PSMF1,PSME3,GFRA3,PRKCA,PDGFRB,UBC,GFRA2,SPRED2,CALM3,YWHAB,NRG4,WDR83,PSMD9,PPP2R5A,PSMA1,PSMC2,FGFR3,FN1,SPRED1,FGF2,AHCYL1,FGF19,FGF5,DUSP7,RASA1,SOS1,ITPR2,PPP2R5B,CAMK2D,PSMB5,FYN,ITGA2B,MIR5004,FGF9,GFRA4,VWF,RAPGEF2,DUSP4,PSMD13,PPP2R5E,RASAL1,IL2,PDGFB,CAMK2G,ERBB4,VCL,DUSP10,FGB,SHC2,PSME1,IRS2,FGF23,PSMB3,LAT,ERBB3,PDGFRA,IL17RD,HGF,KDR,FGF6,LAMTOR2,RASGRP3,FGA,KL,FGF22,FGFR1,KITLG,IL2RA,PSMC1,ARRB1,CSF2,ARTN,MET,PEA15,PSMB6,KBTBD7,HRAS,PPP2R5D,PSMD12,FGF8,MAP2K2,RPS27A,IL3,VEGFA,PRKCZ,PSMD1,PPP2R1A,CAMK2A,SPTBN5,PTPRA,KRAS,RAP1B,JAK1,PHB1,CALM1,PEBP1,SPTAN1,EGF,NRG2,FGF18,PSMA6,RAF1,MAP2K1,PSPN,CSF2RB,SPTBN4,PSMB8,PPP5C,SYNGAP1,ANGPT1,DUSP1,PSMB7,FGF7,NRAS,PSMB11,SPTB,FGF10,PSMB4,PSME4,ACTN2,DUSP2,SEM1,RASGRP1,PSMA8,PSMD4,RASGRP4,PSMD2,SHC3,PSMD6,FGF1,ERBB2,PPP2R1B,PPP2R5C,PSMD11,NRG1,TEK,BTC,PDGFA,RANBP9,KSR2,SPTA1,ITGB3,IRS1
R-HSA-71387	Metabolism of carbohydrates	0.0389106227514026	-3.24648798719464	296	270	0.0298870932034536	9034	10285	132158,9394,7086,7957,10082,166012,4190,693216,5232,3373,10057,5837,2026,9435,2997,10165,9972,6484,2131,8702,5518,2990,9469,3098,3425,5313,55276,5507,54480,801,7360,125206,3101,29940,6518,8372,11097,6888,411,2542,3099,2805,5568,11041,8789,10894,10762,5091,1462,5519,23636,279,9953,55746,6527,2806,3036,51181,9061,9951,276,3074,3938,51071,5236,3795,63827,51363,26007,2584,4928,83539,6483,216,8086,1463,23324,2799,4969,2998,2597,6120,8704,11046,5315,337876,768213,53371,57214,50515,79023,9942,11285,6517,2821,347734,22856,10861,26229,6482,2023,9688,5209,1634,64711,26330,8402,229,348995,221823,3161,5528,3906,5208,10331,113189,200010,6233,5567,2582,2132,1464,6576,178,2720,11261,9955,55790,5210,4927,8703,1836,6476,226,79586,22934,81929,9348,9956,85414,5836,5214,23511,2027,11081,23279,51000,126792,5257,5903,55576,378884,92579,135152,25796,6513,4166,23225,79411,4123,669,27159,9818,5261,9653,10007,3340,5226,1118,6383,55974,6526,3037,808,10327,8534,5211,4958,57122,64132,93010,9883,8021,2992,64579,79369,266722,26035,10675,280,10678,7316,9672,6514,9631,10855,26291,222537,4126,8604,6382,8972,100101267,23165,5223,2203,11181,4125,9331,64131,1468,144195,23563,5549,6515,2548,5516,2262,3339,6248,4191,7314,55706,5515,57818,2645,6487,132789,5105,7167,6448,5566,375790,5834,2646,92126,10402,6548,2817,27087,100616124,3038,2331,9060,79902,83440,231,805,2538,8692,2683,6523,7311,960,9957,129401,9334,10090,6652,5224,7175,176,55501,51084,60495,2592,55454,6385,2632,4060	GLYCTK,HS6ST1,TKT,EPM2A,GPC6,CHST13,MDH1,MIR631,PGK2,HYAL1,ABCC5,PYGM,ENO2,CHST2,GYS1,SLC25A13,NUP153,ST3GAL4,EXT1,B4GALT4,PPP2R1A,GUSB,CHST3,HK1,IDUA,PKLR,PGM2,PPP1R3C,CHPF2,CALM1,UGP2,SLC5A10,HK3,DSE,SLC2A5,HYAL3,NUP42,TALDO1,ARSB,SLC37A4,HK2,GOT1,PRKACG,B4GAT1,FBP2,LYVE1,NUP50,PC,VCAN,PPP2R1B,NUP62,AMY2A,HS3ST3B1,NUP133,SLC5A4,GOT2,HAS1,DCXR,PAPSS1,HS3ST4,AMY1A,HEXB,LCT,DERA,PGM1,KHK,BCAN,CHST15,TKFC,GALK1,NUP98,CHST9,ST3GAL2,ALDH1A1,AAAS,NCAN,MAN2B2,GNS,OGN,GYS2,GAPDH,RPE,B4GALT2,SLC35D2,PKM,CHSY3,MIR671,NUP54,CEMIP,CHST11,NUP37,XYLB,B4GALT7,SLC2A4,GPI,SLC35B2,CHSY1,SLC26A1,B3GAT3,ST3GAL1,ENO1,NUP93,PFKFB3,DCN,HS3ST6,GAPDHS,SLC25A11,ALDOB,NUP43,PRPS1L1,HMMR,PPP2R5D,LALBA,PFKFB2,B3GNT3,CHST14,SLC5A9,RPS27A,PRKACB,GALE,EXT2,CSPG4,SLC25A1,AGL,GLB1,CHP1,HS3ST3A1,CSGALNACT1,PFKFB4,NUP88,B4GALT3,SLC26A2,SI,ALDOA,CHPF,RPIA,SEH1L,NDST3,HS3ST2,SLC45A3,PYGL,PFKP,NUP188,ENO3,KERA,NUP160,SLC35B3,B3GALT6,PHKB,RANBP2,STAB2,NHLRC1,G6PC3,B3GAT2,PGLS,SLC2A1,CHST6,NUP210,GLB1L,MAN2C1,BPGM,CHIA,NUP58,PHKG2,HS2ST1,GNPDA1,NDST1,PGD,CHIT1,SDC2,SLC50A1,SLC5A3,HAS2,CALM3,AKR1A1,CHST1,PFKL,OMD,NUP107,XYLT2,B3GNT7,POM121,NUP214,GYG1,NDST4,B3GNT4,HS6ST3,GLCE,CSPG5,AMY2B,B3GNT2,UBC,SDC3,SLC2A2,NUP155,HPSE,FGF21,HS3ST5,MANBA,SLC25A12,SDC1,MGAM,POM121C,NUP205,PGAM1,FBP1,TREH,MAN2B1,B4GALT6,XYLT1,SLC25A10,SLC2A14,CHST5,PRELP,SLC2A3,GAA,PPP2CB,GPC5,HSPG2,RSC1A1,MDH2,UBB,NDC1,PPP2CA,G6PC2,GCK,ST3GAL3,GNPDA2,PCK1,TPI1,SGSH,PRKACA,AGRN,PYGB,GCKR,DSEL,ST3GAL6,SLC9A1,GPC1,B3GAT1,MIR4647,HAS3,FMOD,PAPSS2,NUP85,ADPGK,AKR1B1,CALM2,G6PC1,HYAL2,B4GALT1,SLC5A1,UBA52,CD44,HS3ST1,NUP35,B4GALT5,UST,SORD,PGAM2,TPR,ACAN,CHST12,CRYL1,HPSE2,GALT,CSGALNACT2,SDC4,GBE1,LUM
R-HSA-1538133	G0 and Early G1	0.0389168403680135	-3.2463282076933	25	25	0.00276732344476422	9034	10285	1874,8900,286826,7153,5928,3065,132660,990,5111,5934,1869,55957,7027,890,1875,91750,7029,1017,983,4605,1859,5933,898,993,9134	E2F4,CCNA1,LIN9,TOP2A,RBBP4,HDAC1,LIN54,CDC6,PCNA,RBL2,E2F1,LIN37,TFDP1,CCNA2,E2F5,LIN52,TFDP2,CDK2,CDK1,MYBL2,DYRK1A,RBL1,CCNE1,CDC25A,CCNE2
R-HSA-165159	mTOR signalling	0.0404368227322286	-3.20801445536876	39	38	0.00420633163604162	9034	10285	1977,10542,1975,57521,5564,6198,6194,81617,7529,29904,207,51719,84335,55437,1978,6794,2475,8649,7248,5565,389541,28956,58528,5563,64223,5494,53632,51422,5571,208,64121,1981,6009,5562,7249,10670,92335,55004	EIF4E,LAMTOR5,EIF4B,RPTOR,PRKAB1,RPS6KB1,RPS6,CAB39L,YWHAB,EEF2K,AKT1,CAB39,AKT1S1,STRADB,EIF4EBP1,STK11,MTOR,LAMTOR3,TSC1,PRKAB2,LAMTOR4,LAMTOR2,RRAGD,PRKAA2,MLST8,PPM1A,PRKAG3,PRKAG2,PRKAG1,AKT2,RRAGC,EIF4G1,RHEB,PRKAA1,TSC2,RRAGA,STRADA,LAMTOR1
R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	0.0404368227322286	-3.20801445536876	39	38	0.00420633163604162	9034	10285	7058,9508,23275,170689,9037,56999,11095,57188,339366,140766,11096,9719,170692,10417,80070,55901,10418,11173,7057,9507,145173,54507,92949,11174,79875,157869,23145,9509,171019,54437,80731,170691,221981,170690,81794,11093,81792,9510	THBS2,ADAMTS3,POFUT2,ADAMTS15,SEMA5A,ADAMTS9,ADAMTS8,ADAMTSL3,ADAMTSL5,ADAMTS14,ADAMTS5,ADAMTSL2,ADAMTS18,SPON2,ADAMTS20,THSD1,SPON1,ADAMTS7,THBS1,ADAMTS4,B3GLCT,ADAMTSL4,ADAMTSL1,ADAMTS6,THSD4,SBSPON,SSPOP,ADAMTS2,ADAMTS19,SEMA5B,THSD7B,ADAMTS17,THSD7A,ADAMTS16,ADAMTS10,ADAMTS13,ADAMTS12,ADAMTS1
R-HSA-167044	Signalling to RAS	0.0425360821295826	-3.15740257195672	256	234	0.0259021474429931	9034	10285	2260,4254,3559,5700,2243,27006,9365,28956,2251,25780,3082,4233,1437,9048,408,3265,5694,84078,8682,5707,5605,6233,3562,2253,5718,5528,2534,5693,4803,817,5529,5719,9693,1846,7450,100847012,3674,64096,2254,5720,11221,2244,25759,5155,818,2066,7414,5900,8437,3558,54756,5691,27040,8074,2065,5156,8660,2255,5692,5603,6710,4893,122706,143471,5710,10125,1844,7979,23198,88,5519,5527,3084,5717,2064,53358,9861,2246,115727,5708,3667,5154,10048,283455,6708,3690,7010,685,3845,5908,3716,5786,5518,7867,815,51332,9542,8817,5687,5894,5037,1950,6709,5245,801,5536,1439,57731,5696,5604,5623,5695,2252,1843,8831,284,5595,10818,7311,26281,5699,5600,805,5684,4902,153090,64926,5713,10256,152559,9978,2266,5706,10718,2248,2906,5711,4914,3815,4684,673,8826,6711,8649,10142,2668,2905,409,5516,5702,399473,3567,1847,4763,9462,2249,1850,5906,2674,2885,5747,5922,3718,4296,8822,5515,7314,4140,1445,80824,6714,1432,10213,54518,5698,5979,8452,4747,3560,816,5714,5923,9491,2676,10197,2903,2069,10817,2263,2675,5898,5159,7316,5525,5715,5682,7529,145957,84292,200734,808,5921,6654,5526,9965,2250,1849,2335,161742,2247,5701,2261,5686,6300,9261,5690,1742,6712,221002,3717,5685,3568,1848,5594,6464,5924,2904,5704,10156,2264,8315,1839,1956,5899	FGFR1,KITLG,IL2RA,PSMC1,FGA,FGF22,KL,LAMTOR2,FGF6,RASGRP3,HGF,MET,CSF2,ARTN,ARRB1,HRAS,PSMB6,KBTBD7,PEA15,PSMD1,MAP2K2,RPS27A,IL3,FGF8,PSMD12,PPP2R5D,FYN,PSMB5,NGF,CAMK2D,PPP2R5E,PSMD13,RAPGEF2,DUSP4,VWF,MIR5004,ITGA2B,GFRA4,FGF9,PSME1,DUSP10,FGB,SHC2,PDGFB,CAMK2G,ERBB4,VCL,RALGDS,RASAL1,IL2,IL17RD,PSMB3,LAT,FGF23,ERBB3,PDGFRA,IRS2,FGF10,PSMB4,MAPK13,SPTB,NRAS,PSMB11,PSMA8,PSMD4,RASGRP1,DUSP2,SEM1,PSME4,ACTN2,PPP2R1B,PPP2R5C,NRG1,PSMD11,ERBB2,SHC3,PSMD6,FGF1,RASGRP4,PSMD2,IRS1,PDGFA,RANBP9,KSR2,SPTA1,ITGB3,TEK,BTC,KRAS,RAP1B,JAK1,PTPRA,PPP2R1A,MAPKAPK3,CAMK2A,SPTBN5,NRG2,FGF18,PSMA6,RAF1,PEBP1,EGF,SPTAN1,PHB1,CALM1,PPP5C,CSF2RB,SPTBN4,PSMB8,MAP2K1,PSPN,PSMB7,FGF7,DUSP1,SYNGAP1,ANGPT1,MAPK3,FRS2,UBA52,FGF20,PSMB10,MAPK11,CALM2,PSMA3,NRTN,DAB2IP,RASAL3,PSMD7,CNKSR1,PAQR3,RBX1,FGG,PSMC6,NRG3,FGF3,GRIN2D,PSMD5,NTRK1,KIT,NCAM1,BRAF,IQGAP1,SPTBN1,LAMTOR3,AKAP9,GDNF,GRIN2C,ARRB2,PPP2CB,PSMC3,SPRED3,IL5,DUSP5,NF1,RASAL2,FGF4,DUSP8,RAP1A,GFRA1,GRB2,PTK2,RASA2,JAK3,MAP3K11,FGF17,PPP2CA,UBB,MARK3,CSK,DUSP16,SRC,MAPK14,PSMD14,APBB1IP,PSMB9,RET,CUL3,NEFL,IL2RB,CAMK2B,PSMD8,RASGRF1,PSMF1,GFRA3,PSME3,GRIN2A,EREG,FRS3,FGFR2,GFRA2,RALA,PDGFRB,UBC,PPP2R5A,PSMD9,PSMA1,YWHAB,NRG4,WDR83,SPRED2,CALM3,RASA1,SOS1,PPP2R5B,FGF19,FGF5,DUSP7,FN1,SPRED1,FGF2,PSMC2,FGFR3,PSMA5,MAPK12,MAPKAPK2,PSMB2,DLG4,SPTBN2,RASGEF1A,JAK2,PSMA4,IL5RA,DUSP6,MAPK1,SHC1,RASGRF2,GRIN2B,PSMC4,RASA4,FGFR4,BRAP,HBEGF,EGFR,RALB
R-HSA-382551	Transmembrane transport of small molecules	0.0435039569794906	-3.13490337997881	677	609	0.0674119991144565	9034	10285	51310,111,26154,4645,23539,81614,5714,170572,120,100506403,9114,816,344905,10864,2512,5702,2566,4308,1468,144195,1182,481,6515,284111,6549,23,7314,55706,8894,123041,363,359,1811,284525,5566,5706,10786,55129,30061,51458,2562,486,6565,2645,80727,7442,1186,2793,85413,23400,6566,2646,6548,6512,7220,282679,57084,6041,6580,9914,2778,57205,246213,284129,126969,129401,2791,53826,9635,100847046,2792,477,23511,159963,23279,9123,140679,51000,9177,6513,121260,1244,23225,55970,10613,91445,148229,6511,259232,63982,5686,56172,525,1080,65266,79895,5685,108,10350,2561,206358,64241,59345,9056,6547,6588,5205,6561,5682,225,9550,808,3767,10396,10956,5701,23443,444,9629,523,162514,80036,11182,27032,9491,23657,121601,261729,23456,6540,51802,84102,9631,6563,10345,83697,23120,6531,144453,5349,5243,8992,54407,11046,196527,57380,24,10058,25769,358,57030,23545,526,84912,5691,8884,6508,347734,6059,79023,219931,2039,817,490,6529,5693,55676,6533,8170,9688,51761,5719,348938,56302,10559,55089,8766,115019,6528,6553,55117,10999,133418,563,348995,23200,338440,6509,91749,23327,200010,200959,5304,5718,10723,57192,57101,5575,4927,53828,5348,2783,23678,23169,81929,28962,3163,7780,169026,5576,254428,28232,10079,1836,487,6575,64137,7439,5696,7991,2555,6584,1179,483,109,5695,8671,54331,64849,23428,10110,6005,361,540,6536,6400,113,8501,57419,50636,2782,815,123606,41,7809,10312,64924,124935,115286,476,11059,11309,28231,65268,3162,125206,152519,6507,160728,255231,2741,10762,5717,2786,5825,2281,9154,55283,9861,115,26503,374868,81031,5573,245972,4891,55746,6717,6527,80024,6340,5692,64240,10351,10991,25800,84239,89845,51606,55240,122706,2030,6556,54795,6520,1317,6571,2743,57181,143471,5710,21,11136,56301,23198,4928,366,5002,7979,5172,4363,10213,55515,375318,23165,100101267,528,90423,50617,6559,5698,26291,203859,6538,2495,51393,2558,22802,493,23461,23446,340024,9619,213,57185,2570,51764,6248,6833,81539,285335,57198,55503,23516,9376,3359,57818,7037,29850,5711,2788,57468,6570,9194,100616124,6521,57153,119,79902,6262,10568,5699,6558,79054,7311,6523,57835,5577,5684,10347,805,29985,2538,114134,495,40,2559,55315,133308,28965,29988,364,115111,5713,7175,489,6539,23250,161003,2557,1497,5903,5704,51382,6579,8001,107,335,6263,6564,150159,79901,57194,285195,92579,66035,5690,79751,478,127124,6261,3934,6522,55867,6506,9187,9818,480,6505,6530,28234,54896,340273,9356,5715,11160,10599,7781,55974,6550,6526,57348,64116,2787,64078,57122,482,57113,6578,10197,9883,8021,112,6514,56606,682,28982,55107,7316,6557,148867,348932,2560,5720,155066,360,2784,818,53371,245973,285242,5824,222962,389015,57719,60482,80736,94235,6510,551,7222,26266,10861,283375,6582,23382,51076,53373,1356,529,6517,22841,65125,2567,1965,9429,23315,89872,6338,353189,115584,204962,7226,153201,54831,57127,54822,94015,5694,6541,6339,7225,6534,6233,5567,5707,376497,155184,196883,488,1187,2554,29986,57578,9152,861,5700,5244,285175,9497,362,1180,23457,23460,118,6048,7018,11194,85414,6560,59341,6543,479,10057,57130,9311,8140,26133,9197,533,116085,7779,10349,9972,8714,54716,85320,10060,146802,6337,8989,6574,3098,140803,2040,9153,3101,6542,6518,5894,55244,11097,5687,801,345274,154091,10681,6569,491,51296,1188,283652,2790,57282,6446,53919,2569,23636,5708,200909,3099,79815,2542,5568,9057,6546,7415,9990,6581,6568,496,6519,343,55343,535,79139,10257,6583,114,91319,83733,7223,8504,55356,8086,9498,5350,117247,3177	SLC22A17,ADCY5,ABCA12,MYO5B,SLC16A8,NIPA2,PSMD8,HTR3C,ADD3,LOC100506403,ATP6V0D1,CAMK2B,ATP13A5,SLC22A7,FTL,PSMC3,GABRG2,TRPM1,SLC25A10,SLC2A14,CLCN3,ATP1B1,SLC2A3,SLC13A5,SLC9A2,ABCF1,UBB,NDC1,EIF2S2,SLC24A4,AQP6,AQP2,SLC26A3,SLC9C2,PRKACA,PSMC6,SLC17A3,ANO10,SLC40A1,RHCG,GABRB3,FXYD2,SLC15A2,GCK,TTYH3,TRPV1,CLCN7,GNGT2,SLC22A16,ATP13A2,SLC16A1,GCKR,SLC9A1,SLC1A7,TRPC1,AQP11,SLC17A6,RNASEL,SLC22A1,ATP2C2,GNAS,ATP10D,SLC17A8,SLC26A11,SLC44A3,NUP35,GNG11,FXYD6,CLCA2,MIR5010,GNGT1,ATP1A2,NUP188,SLC5A12,NUP160,SLC16A3,SLC32A1,SLC35B3,HTR3B,SLC2A1,SLC15A4,ABCC2,NUP210,GNG12,ERLIN1,RNF185,ATP8B3,SLC1A6,NALCN,ANO3,PSMA5,ANKH,ATP6V1B1,CFTR,WNK4,ATP8B4,PSMA4,ADCY2,ABCA9,GABRB2,SLC36A1,ABCG8,GNB4,SLC7A7,SLC8A3,SLN,ATP8B1,SLC13A1,PSMA1,ABCD2,ATP6V1G1,CALM3,KCNJ11,ATP8A1,OS9,PSMC2,SLC35A3,ASPH,CLCA3P,ATP6V1A,TRPV3,TRPM3,SLC2A6,ATP2C1,PSMF1,SLC7A11,ANO4,STEAP2,ABCB10,SLC6A13,ASIC5,SLC41A2,NUP155,SLC14A1,TRDN,SLC4A9,ATP10B,SLC6A3,BEST3,FXYD3,ABCB1,ATP6V0E1,SLC38A2,SLC35D2,ANO6,MRS2,ABCA4,ABCB6,SLC24A2,AQP1,SLC17A7,ATP6V0A2,ATP6V1B2,SLC35B4,PSMB3,SLC5A6,SLC4A3,SLC35B2,ABCE1,NUP37,TPCN2,DMTN,CAMK2D,ATP2B1,SLC6A1,PSMB5,SLC30A6,SLC6A6,SLC14A2,NUP93,ATP8A2,PSMD13,NIPAL4,TRPV5,SLC35A1,SLC38A4,RAB11A,SLC26A9,SLC5A5,SLC9A5,SLC6A15,SLC27A4,EMB,AZGP1,NUP43,ATP11B,ANO9,SLC1A4,MFSD4B,NEDD4L,SLC5A9,GABRR3,PIP,PSMD12,SLC12A7,MCOLN1,ANO2,PRKAR1B,NUP88,FXYD4,FXYD1,GNB2,SGK3,SLC35D1,SEH1L,OSTM1,HMOX2,SLC30A2,SLC30A8,PRKAR2A,SLC41A1,SLCO3A1,ATP9A,SLC26A2,ATP2A1,SLC20A2,ABCG4,BEST1,PSMB8,TUSC3,GABRA2,SLC22A5,CLCA1,ATP1B3,ADCY3,PSMB7,SLC4A4,GNG2,SLC13A3,SLC7A8,SGK2,RHAG,AQP4,ATP7B,SLC6A9,SEL1L,ADCY7,SLC43A1,SLC24A3,ANO7,GNB1,CAMK2A,NIPA1,ASIC1,BSND,TCIRG1,SLC30A5,SLC43A2,SLC25A26,ATP1A1,WWP1,SLCO2B1,SLCO4A1,WNK2,HMOX1,SLC5A10,NIPAL1,SLC1A3,SLC5A8,MCOLN2,GLRA1,NUP50,PSMD11,GNG4,ABCD3,FKBP1B,SLC28A1,MCOLN3,PSMD6,ADCY9,SLC17A5,ATP9B,SLC2A10,PRKAR1A,ATP6V0D2,SLC11A2,NUP133,SRI,SLC5A4,SLC8B1,SCNN1G,PSMB4,ABCG5,ABCA8,SLC38A3,SLC39A6,ATP13A4,ABCC10,ATP6V1H,STEAP3,PSMB11,SLC29A1,SLC11A1,TRPM4,SLC3A2,SLC31A1,SLC18A2,GLRB,SLC39A10,PSMA8,PSMD4,ABCA3,SLC7A9,SLC7A10,PSME4,NUP98,AQP9,SLC22A18,SEM1,SLC26A4,ABCC1,PSMD14,ASIC4,AQP12A,NUP205,POM121C,ATP6V1C1,ATP6V1E2,ATP6V0A4,SLC12A3,PSMB9,FGF21,ANO5,SLC6A11,FTH1,TRPV2,GABRA5,CLCA4,ATP2B4,ABCA5,SLC44A1,SLC6A19,ABCG1,ALB,NIPAL3,GABRR2,GNG13,RSC1A1,ABCC8,SLC38A1,SLC9C1,ATP8B2,TRPV6,SLC39A14,SLC22A8,HTR3A,G6PC2,TFRC,TRPM5,PSMD5,GNG7,SLC12A5,SLC18A1,SLC16A7,MIR4647,SLC4A1,SLC44A2,ADD2,NUP85,RYR2,SLC34A2,PSMB10,SLC12A2,TRPM8,UBA52,SLC5A1,SLC4A5,PRKAR2B,PSMA3,ABCA7,CALM2,SLC39A3,G6PC1,SLC2A13,ATP4A,ASIC2,GABRA6,SLC29A3,SLC9B2,SLC27A6,SLC2A8,AQP7,SLC26A7,PSMD7,TPR,ATP2A3,SLC6A12,ATP11A,STOML3,GABRA4,CTNS,RANBP2,PSMC4,ATP6V1D,SLCO1A2,GLRA3,ADCY1,APOA1,RYR3,SLC15A1,SLC9B1,CYBRD1,ATP10A,SLC9A9,G6PC3,SLC2A11,PSMB2,SLC25A22,ATP1A3,ATP6V1G3,RYR1,LCN2,SLC4A2,SLC22A11,SLC1A2,SLC24A1,NUP58,ATP1A4,SLC1A1,SLC6A2,SLCO1B3,SLC66A1,ABCB5,SLC22A6,PSMD9,ERLIN2,SLCO1B1,SLC30A3,SLC50A1,SLC9A3,SLC5A3,TTYH1,SLC39A8,GNG5,SLC28A3,NUP107,ATP1B2,TRPC7,SLCO2A1,PSME3,POM121,NUP214,ADCY6,SLC2A2,SLC2A9,BSG,FLVCR1,ANO1,UBC,SLC12A1,SLC30A7,SLC6A18,GABRB1,PSME1,ATP6V0E2,AQP3,GNB3,CAMK2G,NUP54,ATP6V1C2,HTR3E,PEX19,SLC29A4,SLC9A4,ANO8,SLC5A7,SLC44A4,GNG8,SLC1A5,AVP,TRPC3,SLC13A4,SLC26A1,SLC39A5,SLC22A2,AHCYL2,CUTC,TPCN1,CP,ATP6V1E1,SLC2A4,RAB11FIP2,WNK1,GABRG3,EIF2S1,ABCG2,SLC9A8,AQP10,SCNN1B,SLCO4C1,SLC5A11,SLC44A5,TRPM2,SLC36A2,BEST2,RHBG,TRPM7,TTYH2,PSMB6,SLC7A1,SCNN1D,TRPC6,SLC6A7,RPS27A,PRKACB,PSMD1,SLC27A1,SLC2A7,ADCY4,ATP2A2,CLCNKA,GABRA1,SLC39A2,UNC79,SLC6A5,RUNX1,PSMC1,ABCB4,UNC80,SLC4A7,AQP5,CLCN1,ABCB9,ABCA6,ADD1,RNF5,TF,ABCB8,SLC45A3,SLC12A4,TRPV4,SLC8A2,ATP12A,ABCC5,ATP13A1,ASIC3,SLC7A5,TRPC4AP,SLC33A1,ATP6V0B,SLC22A12,SLC30A1,ABCA10,NUP153,ABCC3,SLC6A20,ABCC11,ABCC9,SLC47A2,SCNN1A,TRPA1,SLC20A1,HK1,TRPM6,STOM,SLC28A2,HK3,SLC7A2,SLC2A5,RAF1,SLC47A1,NUP42,PSMA6,CALM1,SLC10A6,SLC2A12,GNB5,SLC34A1,ATP2B2,SLC15A3,CLCNKB,SLC24A5,GNG10,SLC4A10,SGK1,SLCO1C1,GABRR1,NUP62,PSMD2,HTR3D,HK2,NIPAL2,SLC37A4,PRKACG,SLC7A6,SLC8A1,VCP,SLC12A6,SLC22A3,SLC17A1,ATP4B,SLC3A1,AQP8,SLC35C1,ATP6V0A1,DERL1,ABCC4,SLC22A4,ADCY8,DERL3,SLC25A18,TRPC4,PEX3,SLC22A15,AAAS,SLC4A8,PLN,SLC16A10,SLC29A2
R-HSA-112315	Transmission across Chemical Synapses	0.0436072479990977	-3.13253190393182	217	199	0.0220278946203232	9034	10285	805,6580,43,9495,2559,1143,1175,10815,2791,6539,100616414,5566,783,8825,2562,2788,1141,2793,2906,3768,673,1134,3773,6512,2905,10142,2566,27163,6854,83988,10368,51764,2570,5331,785,2890,81539,111,4646,4905,784,8499,4193,2897,6844,6538,4747,3312,8500,1144,55327,816,2558,3760,2903,9463,5923,6237,100126325,6540,112,84254,5578,8497,2899,217,2770,1145,1173,2036,8973,10550,808,2901,2787,1146,8541,6511,1742,6506,2550,108,1142,2561,5594,5170,59345,163,6505,23426,2557,2904,2792,6196,5924,1135,140679,2898,107,55970,55799,5579,3772,6195,1136,320,1312,1739,2783,2900,3763,2572,1139,2771,3265,9254,777,2773,5567,200959,6812,59283,23236,10369,196883,2554,3761,7915,80331,817,6582,2774,6529,5582,2567,6531,2752,54407,2560,1103,10497,2784,818,590,346562,1138,57030,94235,161,60482,11094,781,114,6857,6571,8224,88,406974,6532,3766,2790,2569,2786,6616,5568,3765,9568,115,55584,27165,3762,113,2782,27092,815,2893,27020,5894,10681,773,801,6507,2555,18,5864,2891,9256,5330,1137,80852,2571,160,22999,54331,2744,109,3759,814,1385	CALM2,SLC22A1,ACHE,AKAP5,GABRA6,CHRNB4,AP2S1,CPLX1,GNG11,SLC6A12,MIR4761,PRKACA,CACNB2,LIN7A,GABRB3,GNG7,CHRNB2,GNGT2,GRIN2D,KCNJ12,BRAF,CHRNA1,KCNJ16,SLC1A7,GRIN2C,AKAP9,GABRG2,NAAA,SYN2,NCALD,CACNG3,GNG13,GABRR2,PLCB3,CACNB4,GRIA1,SLC38A1,ADCY5,MYO6,NSF,CACNB3,PPFIA2,MDM2,GRIK1,VAMP2,SLC6A11,NEFL,HSPA8,PPFIA1,CHRND,LIN7C,CAMK2B,GABRA5,KCNJ3,GRIN2A,PICK1,RASGRF1,RRAS,MIR935,SLC6A13,ADCY6,CAMKK1,PRKCA,PPFIA4,GRIK3,ALDH2,GNAI1,CHRNE,AP2M1,EPB41L1,CHRNA6,ARL6IP5,CALM3,GRIK5,GNG5,CHRNG,PPFIA3,SLC1A6,DLG4,SLC1A2,GABBR1,ADCY2,CHRNB3,GABRB2,MAPK1,PDPK1,GNB4,AP2B1,SLC1A1,GRIP1,GABRA4,GRIN2B,GNGT1,RPS6KA2,RASGRF2,CHRNA2,SLC32A1,GRIK2,ADCY1,GNG12,CACNA2D3,PRKCB,KCNJ15,RPS6KA1,CHRNA3,APBA1,COMT,DLG1,GNB2,GRIK4,KCNJ6,GAD2,CHRNA7,GNAI2,HRAS,CACNA2D2,CACNA1E,GNAI3,PRKACB,GABRR3,STXBP1,CACNG8,PLCB1,CACNG2,ADCY4,GABRA1,KCNJ4,ALDH5A1,DNAJC5,CAMK2D,SLC22A2,GNAL,SLC6A1,PRKCG,GABRG3,SLC6A3,GLUL,SLC38A2,GABRB1,CHAT,UNC13B,GNB3,CAMK2G,BCHE,GNAT3,CHRNA5,SLC17A7,GNG8,AP2A2,SLC5A7,CACFD1,CACNA2D1,ADCY8,SYT1,SLC18A2,SYN3,ACTN2,MIR197,SLC6A4,KCNJ10,GNG10,GABRR1,GNG4,SNAP25,PRKACG,KCNJ9,GABBR2,ADCY9,CHRNA9,GLS2,KCNJ5,ADCY7,GNB1,CACNG4,CAMK2A,GRIA4,NPTN,RAF1,GNB5,CACNA1A,CALM1,SLC1A3,GABRA2,ABAT,RAB3A,GRIA2,TSPOAP1,PLCB2,CHRNA4,GRIP2,GAD1,AP2A1,RIMS1,GNG2,GLS,ADCY3,KCNJ2,CAMK4,CREB1
R-HSA-912526	Interleukin receptor SHC signaling	0.0445856462682504	-3.11034330430577	255	233	0.0257914545052026	9034	10285	4684,673,8826,6711,8649,10142,2668,2905,409,2266,5706,10718,2248,2906,5711,3815,4902,153090,64926,5713,10256,152559,9978,5595,10818,7311,5699,26281,805,5684,5296,4747,3560,816,5714,5295,6714,10213,5698,54518,5979,8452,5515,8822,7314,4140,1445,80824,5516,5702,399473,3567,4763,1847,9462,1850,2249,5906,2885,2674,5747,5922,3718,4296,5921,6654,5526,9965,2250,1849,2335,161742,2247,5701,9846,2261,5525,5715,5682,7529,145957,84292,200734,808,2675,5159,7316,5923,9491,10197,2676,2903,2069,10817,2263,5777,8315,1839,1956,6464,5924,2904,5704,10156,2264,5291,221002,3717,5685,3568,1848,5594,5293,5686,5690,1742,6712,5707,5605,6233,3562,2253,5718,5528,3265,5694,84078,8682,4233,1437,9048,408,2260,4254,3559,5700,2243,9365,27006,2251,28956,25780,3082,54756,3635,27040,8074,5691,2065,5156,8660,5720,2244,3636,11221,25759,5155,818,2066,7414,8437,3558,5290,5529,5719,1846,9693,7450,100847012,3674,64096,2254,5693,2534,817,3667,5154,10048,283455,6708,3690,7010,685,5519,5717,3084,5527,2064,53358,9861,2246,115727,5708,143471,5710,10125,1844,7979,23198,88,2255,5692,6710,4893,122706,8503,5695,2252,1843,8831,284,5536,1439,57731,5696,5604,5623,9542,8817,5687,5894,5037,1950,6709,5245,801,3845,5908,3716,5786,5518,51332,815	NCAM1,BRAF,IQGAP1,SPTBN1,LAMTOR3,AKAP9,GDNF,GRIN2C,ARRB2,FGG,PSMC6,NRG3,FGF3,GRIN2D,PSMD5,KIT,NRTN,DAB2IP,RASAL3,PSMD7,CNKSR1,PAQR3,RBX1,MAPK3,FRS2,UBA52,PSMB10,FGF20,CALM2,PSMA3,PIK3R2,NEFL,IL2RB,CAMK2B,PSMD8,PIK3R1,SRC,PSMD14,PSMB9,APBB1IP,RET,CUL3,PPP2CA,FGF17,UBB,MARK3,CSK,DUSP16,PPP2CB,PSMC3,SPRED3,IL5,NF1,DUSP5,RASAL2,DUSP8,FGF4,RAP1A,GRB2,GFRA1,PTK2,RASA2,JAK3,MAP3K11,RASA1,SOS1,PPP2R5B,FGF19,FGF5,DUSP7,FN1,SPRED1,FGF2,PSMC2,GAB2,FGFR3,PPP2R5A,PSMD9,PSMA1,YWHAB,NRG4,WDR83,SPRED2,CALM3,GFRA2,PDGFRB,UBC,RASGRF1,PSMF1,PSME3,GFRA3,GRIN2A,EREG,FRS3,FGFR2,PTPN6,BRAP,HBEGF,EGFR,SHC1,RASGRF2,GRIN2B,PSMC4,RASA4,FGFR4,PIK3CB,RASGEF1A,JAK2,PSMA4,IL5RA,DUSP6,MAPK1,PIK3CD,PSMA5,PSMB2,DLG4,SPTBN2,PSMD1,MAP2K2,RPS27A,IL3,FGF8,PSMD12,PPP2R5D,HRAS,PSMB6,KBTBD7,PEA15,MET,CSF2,ARTN,ARRB1,FGFR1,KITLG,IL2RA,PSMC1,FGA,KL,FGF22,FGF6,LAMTOR2,RASGRP3,HGF,IL17RD,INPP5D,LAT,FGF23,PSMB3,ERBB3,PDGFRA,IRS2,PSME1,FGB,INPPL1,DUSP10,SHC2,PDGFB,CAMK2G,ERBB4,VCL,RASAL1,IL2,PIK3CA,PPP2R5E,PSMD13,DUSP4,RAPGEF2,VWF,MIR5004,ITGA2B,GFRA4,FGF9,PSMB5,FYN,CAMK2D,IRS1,PDGFA,RANBP9,KSR2,SPTA1,ITGB3,TEK,BTC,PPP2R1B,PSMD11,NRG1,PPP2R5C,ERBB2,SHC3,PSMD6,FGF1,RASGRP4,PSMD2,PSMA8,PSMD4,RASGRP1,DUSP2,SEM1,PSME4,ACTN2,FGF10,PSMB4,SPTB,NRAS,PSMB11,PIK3R3,PSMB7,FGF7,DUSP1,SYNGAP1,ANGPT1,PPP5C,CSF2RB,SPTBN4,PSMB8,MAP2K1,PSPN,NRG2,FGF18,PSMA6,RAF1,PEBP1,EGF,SPTAN1,PHB1,CALM1,KRAS,RAP1B,JAK1,PTPRA,PPP2R1A,SPTBN5,CAMK2A
R-HSA-1280215	Cytokine Signaling in Immune system	0.0450005539082193	-3.10108048021603	756	679	0.0751605047597963	9034	10285	3839,414062,3312,3551,5714,3136,816,2309,6778,2353,51447,6810,3575,5296,3932,3664,1326,3135,9655,6714,5295,3576,23321,80824,117854,1445,4140,3107,3606,7314,5515,55706,7040,79155,729230,4296,3718,3553,2885,2674,6416,1847,3605,399473,4791,5702,1154,3590,5516,1982,9470,3127,2668,5618,27177,6351,8649,673,6885,3429,3433,8519,4940,29949,5566,5706,8357,4067,9978,129401,8744,10256,1271,6737,4988,29760,64926,5580,2308,8350,3838,5292,10612,9636,3120,10818,3444,6041,3572,960,3976,3603,81603,3659,23225,5777,3456,5291,2264,23511,23279,6777,115361,2904,3556,3455,5924,5594,5293,5335,5300,7534,1848,943,1441,3133,3091,5685,3717,8554,10454,2162,3601,54472,6352,56300,5770,8454,1981,5686,3929,2634,8358,6868,5701,23529,2335,8968,1849,2250,1974,6654,23291,8945,808,200734,9020,5617,6356,145957,5371,5682,126961,5610,7297,25970,9631,598,3452,23650,3837,2069,8784,3552,3394,9491,5156,10068,6349,5691,8651,1958,3113,6935,941,5657,11074,8835,200081,8437,6657,7414,2920,90865,5155,1977,207,25759,11221,2210,27189,5781,2254,3674,7525,3587,7450,3566,5719,5529,9688,132014,79023,817,5693,3565,163702,3669,3448,8807,91543,5718,5528,282616,7422,3562,23586,6774,693215,5605,3911,2625,4312,6095,3726,348995,3449,1052,84078,1901,10148,53840,301,5451,9244,5896,6597,9048,7318,6348,81929,1437,5971,146433,8995,3082,8672,100847079,27006,970,2243,4254,4927,282618,2260,8831,8354,4313,58985,7334,5695,5743,50616,8503,8740,54014,9775,3440,7341,5623,23087,6500,5696,1439,5536,4734,567,5245,3162,8808,1950,5037,332,64127,9542,3320,51332,815,4599,3588,27179,5786,5908,3845,685,6363,55746,836,4692,330,3667,8809,3594,54739,2246,9861,4050,6850,11213,10762,2064,5717,5527,240,7157,88,4928,23198,7979,1844,920,5710,143471,79923,9235,122706,4893,6710,8600,6347,149233,5692,3660,5008,3560,4747,23495,356,8452,5979,1026,54518,10581,5698,100500827,3460,10213,3443,2635,23165,100101267,3118,8822,867,3441,7133,3689,3434,5922,8741,5747,5906,8767,1850,2249,116379,7850,9462,4763,3586,55223,3567,10107,3454,3688,3661,409,2905,10142,329,3119,4600,595,834,6711,6097,8826,79902,4684,3815,3554,10379,5711,9466,2906,2248,10718,6809,10437,53833,2266,10410,152559,7175,5713,8878,939,57161,2317,1435,153090,8638,4902,958,5495,5684,5897,4215,805,3663,5699,26281,115362,103,1436,7311,5595,948,6367,85363,1956,1839,4609,3840,8315,10156,11009,5704,4170,4261,5903,23118,6464,9180,9818,2633,3445,53832,4318,58480,25939,57162,3568,7409,221002,246778,4938,6712,1742,3117,5690,10913,115650,3662,6288,25820,3934,2261,9846,161742,2247,653604,1234,57122,10392,3134,9965,3569,8718,5526,27178,8742,3665,5921,3574,3442,55540,5970,388646,5608,7324,84292,9966,7529,2690,3687,4939,5715,5525,6672,7132,944,5159,7316,7431,3604,2537,10538,4055,2675,2263,5724,4502,10817,8021,9883,2903,1444,10197,163351,2676,80263,5923,100616340,3684,10673,8660,3458,5771,2065,27040,8074,3635,3600,53371,3595,54756,3558,51135,2066,818,246,3636,2244,7124,5720,3439,3596,4049,3105,2208,64096,100847012,2919,9693,1846,1230,55128,6773,2323,8352,5290,3122,246330,3106,2534,9173,1398,84818,3570,608,2253,7187,9039,2209,6233,5707,1489,23765,8682,7335,2688,5694,7293,3265,3627,100500842,8355,408,7291,9021,3656,84639,5443,4233,3459,8792,2251,28956,25780,10475,1278,317649,9365,5700,3559,3592,284,4790,6776,1843,2252,402569,4982,9972,3557,80128,3977,3578,5604,57731,7292,51191,133396,6364,801,84868,6709,7706,5894,9830,9246,5687,8817,11097,3593,5518,2357,7189,7412,3383,3716,2889,7010,3690,7726,6708,283455,10048,5154,128178,5708,115727,2185,53358,1270,604,1147,3084,23636,5519,112744,3836,8353,4314,4615,6772,2322,10125,6624,3437,8086,4985,942,2255,3123,50604,684,596	KPNA3,CCL3L3,HSPA8,IKBKB,PSMD8,HLA-H,CAMK2B,FOXO3,STAT6,FOS,IP6K2,STX4,IL7R,PIK3R2,LCK,IRF6,MAP3K8,HLA-G,SOCS5,SRC,PIK3R1,CXCL8,TRIM2,DUSP16,TRIM6,CSK,MARK3,HLA-C,IL18,UBB,PPP2CA,NDC1,TGFB1,TNIP2,CCR2,MAP3K11,JAK3,IL1B,GRB2,GFRA1,MAP2K4,DUSP5,IL17A,SPRED3,NFKB2,PSMC3,CISH,IL11RA,PPP2CB,EIF4G2,EIF4E2,HLA-DRB5,GDNF,PRLR,IL36B,CCL4,LAMTOR3,BRAF,MAP3K7,IFI27,IFIT2,IFITM1,OAS3,IL19,PRKACA,PSMC6,H3C10,LYN,RBX1,NUP35,TNFSF9,CNKSR1,CNTFR,TRIM21,OPRM1,BLNK,RASAL3,PRKCD,FOXO1,H3C1,KPNA2,PIM1,TRIM3,ISG15,HLA-DQB2,FRS2,IFNA7,RNASEL,IL6ST,CD44,LIF,IL16,TRIM8,IRF1,NUP210,PTPN6,IFNB1,PIK3CB,FGFR4,NUP188,NUP160,STAT5B,GBP4,GRIN2B,IL1RAP,IFNAR2,RASGRF2,MAPK1,PIK3CD,PLCG1,PIN1,YWHAZ,DUSP6,TNFRSF8,CSF3R,HLA-E,HIF1A,PSMA4,JAK2,PIAS1,TAB1,F13A1,IL15RA,TOLLIP,CCL5,IL36G,PTPN1,CUL1,EIF4G1,PSMA5,LBP,GBP2,H3C2,ADAM17,PSMC2,CLCF1,FN1,H3C7,DUSP7,FGF5,EIF4A2,SOS1,FBXW11,BTRC,CALM3,SPRED2,MAP3K14,PRL,CCL11,NRG4,PML,PSMA1,H3C14,EIF2AK2,TYK2,SH2B1,NUP155,BCL2L1,IFNA21,TRIM29,KPNB1,EREG,TNFRSF18,IL1A,IRF8,PSMF1,PDGFRA,IL18BP,CCL3L1,PSMB3,SOCS1,EGR1,HLA-DPA1,ZEB1,CD80,PRTN3,TRIM31,SOCS2,TXLNA,RASAL1,SOX2,VCL,CXCL2,IL33,PDGFB,EIF4E,AKT1,SHC2,DUSP10,FCGR1BP,IL17C,PTPN11,FGF9,ITGA2B,YES1,IL10RA,VWF,IL4R,PSMD13,PPP2R5E,NUP93,IL17RE,NUP37,CAMK2D,PSMB5,IL4,IFNLR1,ISG20,IFNA14,IL18RAP,RSAD2,PSMD12,PPP2R5D,IFNL2,VEGFA,IL3,RIGI,STAT3,MIR630,MAP2K2,LAMA5,GATA3,MMP1,RORA,JUNB,NUP43,IFNA16,CEBPD,KBTBD7,S1PR1,EBI3,TRIM34,ANXA1,POU2F1,CRLF1,RAG1,SMARCA4,ARTN,UBA7,CCL3,SEH1L,CSF2,RELB,IL34,TNFSF18,HGF,EIF4G3,MIR5193,FGF22,CD70,FGA,KITLG,NUP88,IFNL1,FGFR1,SYNGAP1,H3C11,MMP2,IL22RA1,UBE2N,PSMB7,PTGS2,IL22,PIK3R3,TNFSF14,BRWD1,EIF4A3,IFNA2,SUMO1,PSPN,TRIM35,SKP1,PSMB8,CSF2RB,PPP5C,NEDD4,B2M,PHB1,HMOX1,IL1RL2,EGF,PEBP1,BIRC5,NOD2,NRG2,HSP90AA1,SPTBN5,CAMK2A,MX1,IL10RB,IL36A,PTPRA,RAP1B,KRAS,BTC,CCL19,NUP133,CASP3,NDN,BIRC3,IRS1,IL18R1,IL12RB1,XAF1,FGF1,PSMD6,LTB,SYK,IRAK3,NUP50,ERBB2,PSMD11,PPP2R5C,ALOX5,TP53,ACTN2,NUP98,PSME4,SEM1,DUSP2,CD4,PSMD4,PSMA8,NANOG,IL32,PSMB11,NRAS,SPTB,TNFSF11,CCL2,IL23R,PSMB4,IRF2,OSM,IL2RB,NEFL,TNFRSF13B,FASLG,CUL3,RET,CDKN1A,APBB1IP,IFITM2,PSMB9,MIR3614,IFNGR2,PSMD14,IFNA6,GBP3,NUP205,POM121C,HLA-DQA2,FGF17,CBL,IFNA4,TNFRSF1B,ITGB2,IFIT1,RASA2,TNFSF13,PTK2,RAP1A,RIPK2,DUSP8,FGF4,IL22RA2,IL1R2,RASAL2,NF1,IL10,TRIM62,IL5,TRIM10,IFNAR1,ITGB1,IRF3,ARRB2,GRIN2C,AKAP9,BIRC2,HLA-DQB1,MX2,CCND1,CASP1,SPTBN1,RORC,IQGAP1,NUP85,NCAM1,KIT,IL1R1,IRF9,PSMD5,IL27RA,GRIN2D,FGF3,NRG3,STX3,IFI30,IL20RB,FGG,IFITM3,PAQR3,TPR,PSMD7,SQSTM1,CD27,PELI2,FLNB,CSF1,DAB2IP,OASL,NRTN,CD40,PPM1B,PSMA3,RAG2,MAP3K3,CALM2,IRF5,PSMB10,FGF20,GBP5,ADAR,CSF1R,UBA52,MAPK3,CD36,CCL22,TRIM5,EGFR,HBEGF,MYC,KPNA4,BRAP,RASA4,IL24,PSMC4,MCL1,CIITA,RANBP2,TAB2,SHC1,OSMR,NUP58,GBP1,IFNA8,IL20RA,MMP9,RHOU,SAMHD1,PELI1,IL5RA,VAV1,RASGEF1A,IL27,OAS1,SPTBN2,DLG4,HLA-DQA1,PSMB2,EDAR,TNFRSF13C,IRF4,SAA1,ARIH1,LCN2,FGFR3,GAB2,SPRED1,FGF2,H3C13,CCR5,NUP107,NOD1,HLA-F,FGF19,IL6,TNFRSF25,PPP2R5B,IL37,TNFSF12,IRF7,RASA1,IL7,IFNA5,IL17RB,RELA,GBP7,MAP2K6,UBE2E1,WDR83,TNFSF15,YWHAB,GHR,ITGAX,OAS2,PSMD9,PPP2R5A,SP100,TNFRSF1A,TNFSF8,PDGFRB,UBC,VIM,TNFRSF9,IFI6,BATF,LTBR,GFRA2,FGFR2,PTAFR,MT2A,FRS3,NUP214,POM121,GRIN2A,CSHL1,PSME3,GBP6,GFRA3,TRIM45,RASGRF1,MIR4758,ITGAM,TNFSF13B,IRS2,IFNG,PTPN2,ERBB3,LAT,FGF23,INPP5D,IL15,NUP54,IL12RB2,IL17RD,IL2,IRAK4,ERBB4,CAMK2G,ALOX15,INPPL1,FGB,TNF,PSME1,IFNA1,IL13,LTA,HLA-A,FCER2,GFRA4,MIR5004,CXCL1,RAPGEF2,DUSP4,CCR1,TRIM68,STAT2,FLT3LG,H3C3,PIK3CA,HLA-DRA,PELI3,HLA-B,FYN,IL1RL1,CRK,IL17RC,IL6R,TNFRSF17,FGF8,TRAF3,UBA3,FCGR1A,RPS27A,PSMD1,CTF1,IL17RA,PEA15,UBE2V1,GH1,PSMB6,TNFRSF4,HRAS,CXCL10,MIR3652,H3C8,ARRB1,TWIST1,SOCS3,IRAK2,IL1F10,POMC,MET,IFNGR1,TNFRSF11A,FGF6,LAMTOR2,RASGRP3,TRIM38,COL1A2,EIF4E3,KL,PSMC1,IL2RA,IL12A,ANGPT1,NFKB1,STAT5A,DUSP1,FGF7,KPNA7,TNFRSF11B,NUP153,IL1RN,TRIM46,LIFR,IL9,MAP2K1,SPTBN4,TNFSF4,HERC5,IL31RA,CCL20,CALM1,HAVCR2,SPTAN1,TRIM25,RAF1,TRIM14,UBE2L6,PSMA6,FGF18,NUP42,IL12B,PPP2R1A,FPR1,TRAF6,VCAM1,ICAM1,JAK1,RAPGEF1,TEK,ITGB3,TRIM26,SPTA1,KSR2,RANBP9,PDGFA,EDARADD,PSMD2,RASGRP4,PTK2B,SHC3,CNTF,BCL6,CHUK,NRG1,NUP62,PPP2R1B,IL17F,KPNA1,H3C6,MMP3,MYD88,STAT1,FLT3,RASGRP1,FSCN1,IFIT3,AAAS,OPRD1,CD86,FGF10,HLA-DRB1,IL20,BST2,BCL2
R-HSA-5655302	Signaling by FGFR1 in disease	0.0450586648460135	-3.09978997499818	38	37	0.00409563869825105	9034	10285	11160,6777,2246,2549,613,1523,3265,9208,5295,11064,9846,2247,6776,8074,2253,7750,2250,6774,11052,6654,26127,2885,4893,2249,2251,26281,8805,10818,2260,3845,5335,9530,6772,2254,8822,5290,399687	ERLIN2,STAT5B,FGF1,GAB1,BCR,CUX1,HRAS,LRRFIP1,PIK3R1,CNTRL,GAB2,FGF2,STAT5A,FGF23,FGF8,ZMYM2,FGF5,STAT3,CPSF6,SOS1,FGFR1OP2,GRB2,NRAS,FGF4,FGF6,FGF20,TRIM24,FRS2,FGFR1,KRAS,PLCG1,BAG4,STAT1,FGF9,FGF17,PIK3CA,MYO18A
R-HSA-8856828	Clathrin-mediated endocytosis	0.0456596666471935	-3.08653993866943	137	127	0.0140580030994023	9034	10285	3092,23396,7037,23048,1785,8218,51429,29924,3267,7474,26052,143425,409,6453,3482,6233,10552,8871,9341,8976,274,8027,7311,408,2017,1175,10097,29988,10618,7018,50813,127833,1856,9892,154,161,10093,1213,90019,551,29763,3312,8322,2580,51138,6844,1759,2060,1211,64708,1129,1601,273,26119,2885,10094,1861,9829,115548,9146,10920,22905,915,867,338,185,5286,7314,23208,3949,1173,5868,8674,10987,10109,8867,1212,6455,6457,22848,10096,85439,26130,9856,9026,10092,7316,25977,54874,6456,11037,29993,5878,6857,920,85021,58513,84251,160,156,8301,9322,50618,1956,29979,9318,112574,950,4036,382,55738,4074,1080,5869,27348,55707,8533,23149,8673,1950,163,917,157,10254,6869,2873,11252	HIP1,PIP5K1C,TFRC,FNBP1,DNM2,CLTCL1,SNX9,EPN1,AGFG1,WNT5A,DNM3,SYT9,ARRB2,ITSN1,IGF2R,RPS27A,ARPC1A,SYNJ2,VAMP3,WASL,BIN1,STAM,UBA52,ARRB1,CTTN,AP2S1,ACTR2,SLC2A8,TGOLN2,TF,COPS7A,SYT2,DVL2,SNAP91,ADRB2,AP2A2,ARPC4,CLTC,SYT8,AVP,PACSIN3,HSPA8,FZD4,GAK,COPS4,VAMP2,DNM1,EPS15,CLTA,COPS7B,CHRM2,DAB2,AMPH,LDLRAP1,GRB2,ARPC3,TOR1A,DNAJC6,FCHO2,HGS,COPS8,EPN2,CD3D,CBL,APOB,AGTR1,PIK3C2A,UBB,SYT11,LDLR,AP2M1,RAB5A,VAMP4,COPS5,ARPC2,SYNJ1,CLTB,SH3GL1,SH3GL3,AAK1,ACTR3,STON2,GAPVD1,KIAA0319,HIP1R,ARPC5,UBC,NECAP1,FNBP1L,SH3GL2,STON1,PACSIN1,RAB5C,SYT1,CD4,REPS1,EPS15L1,SGIP1,AP2A1,GRK2,PICALM,TRIP10,ITSN2,EGFR,UBQLN1,COPS2,SNX18,SCARB2,LRP2,ARF6,ARFGAP1,M6PR,CFTR,RAB5B,TOR1B,NECAP2,COPS3,FCHO1,VAMP8,EGF,AP2B1,CD3G,GRK3,STAM2,TACR1,GPS1,PACSIN2
R-HSA-5654736	Signaling by FGFR1	0.0475868601276709	-3.04519860359096	50	48	0.00531326101394731	9034	10285	2250,6233,6654,673,161742,2247,2253,2248,3265,23767,23768,2549,2246,200734,7316,53834,26281,7311,2255,27006,9365,5595,10818,2260,4893,10817,2251,8074,6714,5295,6464,10253,7314,5515,867,8822,8817,5290,5594,5335,5781,23769,2254,5516,3845,2885,5518,2249	FGF5,RPS27A,SOS1,BRAF,SPRED1,FGF2,FGF8,FGF3,HRAS,FLRT3,FLRT2,GAB1,FGF1,SPRED2,UBC,FGFRL1,FGF20,UBA52,FGF10,FGF22,KL,MAPK3,FRS2,FGFR1,NRAS,FRS3,FGF6,FGF23,SRC,PIK3R1,SHC1,SPRY2,UBB,PPP2CA,CBL,FGF17,FGF18,PIK3CA,MAPK1,PLCG1,PTPN11,FLRT1,FGF9,PPP2CB,KRAS,GRB2,PPP2R1A,FGF4
R-HSA-187687	Signalling to ERKs	0.047821833822714	-3.04027296924069	263	240	0.0265663050697366	9034	10285	10213,6714,1432,8452,5979,5698,54518,3560,4747,5714,816,4763,1847,3567,399473,5702,5516,4296,5922,3718,5747,5906,2885,2674,2249,1850,9462,7314,5515,8822,80824,1445,4140,2248,10718,5706,2266,3815,4914,5711,2906,8649,6711,8826,673,4684,409,2905,2668,10142,5600,5699,26281,7311,5595,10818,5684,805,153090,4902,9978,152559,10256,5713,64926,2904,6464,5924,2264,10156,5704,8315,5899,1956,1839,5690,9261,6300,5686,6712,1742,5685,3717,221002,5594,5335,1848,3568,84292,7529,145957,5682,5715,5525,808,200734,1849,2250,9965,5526,6654,5921,2261,5701,161742,2247,2335,2903,2676,10197,9491,5923,2263,10817,2069,5898,2675,5159,7316,25759,11221,2244,5720,3558,8437,5900,7414,818,2066,5155,6016,54756,8660,5156,2065,27040,8074,5691,1398,817,4803,5693,2534,7450,9693,1846,5529,5719,64096,2254,100847012,3674,3265,8682,84078,5694,3562,5605,6233,5707,5718,5528,2253,9365,27006,2243,5700,4254,3559,2260,3082,28956,25780,2251,9048,1437,4233,408,5696,57731,1439,5536,5623,5604,2252,5695,284,8831,1843,5786,3716,5908,3845,51332,815,7867,5518,57498,5894,5687,9542,8817,801,5245,6709,1950,5037,2064,5527,5717,3084,5519,5708,115727,2246,9861,53358,3690,6708,283455,5154,10048,3667,685,2889,7010,6014,5692,2255,4893,122706,6710,5603,10125,5710,143471,88,23198,7979,1844	PSMD14,SRC,MAPK14,CUL3,RET,PSMB9,APBB1IP,IL2RB,NEFL,PSMD8,CAMK2B,NF1,DUSP5,IL5,SPRED3,PSMC3,PPP2CB,MAP3K11,RASA2,JAK3,PTK2,RAP1A,GRB2,GFRA1,FGF4,DUSP8,RASAL2,UBB,PPP2CA,FGF17,DUSP16,CSK,MARK3,FGF3,NRG3,PSMC6,FGG,KIT,NTRK1,PSMD5,GRIN2D,LAMTOR3,SPTBN1,IQGAP1,BRAF,NCAM1,ARRB2,GRIN2C,GDNF,AKAP9,MAPK11,PSMB10,FGF20,UBA52,MAPK3,FRS2,PSMA3,CALM2,DAB2IP,NRTN,RBX1,PAQR3,CNKSR1,PSMD7,RASAL3,GRIN2B,SHC1,RASGRF2,FGFR4,RASA4,PSMC4,BRAP,RALB,EGFR,HBEGF,PSMB2,MAPKAPK2,MAPK12,PSMA5,SPTBN2,DLG4,PSMA4,JAK2,RASGEF1A,MAPK1,PLCG1,DUSP6,IL5RA,WDR83,YWHAB,NRG4,PSMA1,PSMD9,PPP2R5A,CALM3,SPRED2,DUSP7,FGF5,FGF19,PPP2R5B,SOS1,RASA1,FGFR3,PSMC2,SPRED1,FGF2,FN1,GRIN2A,GFRA3,PSME3,PSMF1,RASGRF1,FGFR2,FRS3,EREG,RALA,GFRA2,PDGFRB,UBC,SHC2,DUSP10,FGB,PSME1,IL2,RASAL1,RALGDS,VCL,CAMK2G,ERBB4,PDGFB,RIT1,IL17RD,IRS2,PDGFRA,ERBB3,LAT,FGF23,PSMB3,CRK,CAMK2D,NGF,PSMB5,FYN,VWF,RAPGEF2,DUSP4,PPP2R5E,PSMD13,GFRA4,FGF9,MIR5004,ITGA2B,HRAS,PEA15,KBTBD7,PSMB6,IL3,MAP2K2,RPS27A,PSMD1,PSMD12,PPP2R5D,FGF8,KL,FGF22,FGA,PSMC1,KITLG,IL2RA,FGFR1,HGF,LAMTOR2,RASGRP3,FGF6,ARTN,CSF2,MET,ARRB1,PSMB8,SPTBN4,CSF2RB,PPP5C,PSPN,MAP2K1,FGF7,PSMB7,ANGPT1,SYNGAP1,DUSP1,PTPRA,JAK1,RAP1B,KRAS,SPTBN5,CAMK2A,MAPKAPK3,PPP2R1A,KIDINS220,RAF1,PSMA6,NRG2,FGF18,CALM1,PHB1,SPTAN1,EGF,PEBP1,ERBB2,PPP2R5C,PSMD11,NRG1,PPP2R1B,PSMD2,RASGRP4,FGF1,PSMD6,SHC3,ITGB3,SPTA1,KSR2,PDGFA,RANBP9,IRS1,BTC,RAPGEF1,TEK,RIT2,PSMB4,FGF10,NRAS,PSMB11,SPTB,MAPK13,RASGRP1,PSMD4,PSMA8,ACTN2,PSME4,SEM1,DUSP2
R-HSA-2586552	Signaling by Leptin	0.0489407402377173	-3.0171450956689	253	231	0.0255700686296214	9034	10285	4747,3560,816,5714,10213,6714,54518,5698,8452,5979,8822,5515,7314,1445,4140,80824,5702,5516,4763,1847,3567,399473,1850,2249,9462,4296,3718,5922,5747,2885,2674,5906,8826,673,4684,8649,6711,2905,10142,2668,409,5706,2266,2248,10718,2906,3815,5711,4902,153090,64926,9978,3952,152559,10256,5713,10818,5595,5699,26281,7311,5684,805,8315,1956,1839,5924,6464,2904,6777,2264,10156,5704,5685,3717,221002,3953,1848,3568,5594,5686,5690,6712,1742,5526,6654,5921,2250,1849,9965,2247,161742,2335,2261,5701,5682,5525,5715,84292,145957,7529,808,200734,2675,25970,5159,7316,10197,2676,9491,5923,2903,10817,2069,2263,54756,5156,2065,5691,27040,8074,8660,5720,25759,11221,2244,7414,818,2066,5155,3558,8437,5529,5719,9693,1846,7450,5781,64096,2254,100847012,3674,2534,5693,817,5707,3562,6774,6233,5605,2253,5528,5718,3265,84078,5694,8682,4233,9048,1437,408,9021,5700,3559,4254,2260,9365,27006,2243,2251,25780,28956,3082,2252,5695,6776,1843,284,8831,5536,5696,57731,1439,5623,5604,5894,5687,8817,9542,1950,6709,5037,801,5245,3716,5908,3845,5786,815,51332,5518,3667,3690,6708,283455,10048,5154,685,7010,5527,3084,5717,5519,2064,2246,9861,53358,5708,115727,5710,143471,10125,7979,1844,88,23198,5692,2255,6710,4893,122706	NEFL,IL2RB,CAMK2B,PSMD8,PSMD14,SRC,APBB1IP,PSMB9,CUL3,RET,FGF17,PPP2CA,UBB,CSK,MARK3,DUSP16,PSMC3,PPP2CB,NF1,DUSP5,IL5,SPRED3,DUSP8,FGF4,RASAL2,MAP3K11,JAK3,RASA2,PTK2,GRB2,GFRA1,RAP1A,IQGAP1,BRAF,NCAM1,LAMTOR3,SPTBN1,GRIN2C,AKAP9,GDNF,ARRB2,PSMC6,FGG,FGF3,NRG3,GRIN2D,KIT,PSMD5,NRTN,DAB2IP,RASAL3,RBX1,LEP,PAQR3,CNKSR1,PSMD7,FRS2,MAPK3,PSMB10,FGF20,UBA52,PSMA3,CALM2,BRAP,EGFR,HBEGF,RASGRF2,SHC1,GRIN2B,STAT5B,FGFR4,RASA4,PSMC4,PSMA4,JAK2,RASGEF1A,LEPR,DUSP6,IL5RA,MAPK1,PSMA5,PSMB2,SPTBN2,DLG4,PPP2R5B,SOS1,RASA1,FGF5,DUSP7,FGF19,FGF2,SPRED1,FN1,FGFR3,PSMC2,PSMA1,PPP2R5A,PSMD9,WDR83,NRG4,YWHAB,CALM3,SPRED2,GFRA2,SH2B1,PDGFRB,UBC,PSME3,GFRA3,PSMF1,RASGRF1,GRIN2A,FRS3,EREG,FGFR2,IL17RD,PDGFRA,ERBB3,PSMB3,LAT,FGF23,IRS2,PSME1,SHC2,DUSP10,FGB,VCL,CAMK2G,ERBB4,PDGFB,IL2,RASAL1,PPP2R5E,PSMD13,RAPGEF2,DUSP4,VWF,PTPN11,GFRA4,FGF9,MIR5004,ITGA2B,FYN,PSMB5,CAMK2D,PSMD1,IL3,STAT3,RPS27A,MAP2K2,FGF8,PPP2R5D,PSMD12,HRAS,KBTBD7,PSMB6,PEA15,MET,ARTN,CSF2,ARRB1,SOCS3,PSMC1,IL2RA,KITLG,FGFR1,KL,FGF22,FGA,FGF6,RASGRP3,LAMTOR2,HGF,FGF7,PSMB7,STAT5A,DUSP1,ANGPT1,SYNGAP1,PPP5C,PSMB8,SPTBN4,CSF2RB,PSPN,MAP2K1,RAF1,PSMA6,FGF18,NRG2,EGF,SPTAN1,PEBP1,CALM1,PHB1,JAK1,RAP1B,KRAS,PTPRA,CAMK2A,SPTBN5,PPP2R1A,IRS1,ITGB3,SPTA1,KSR2,RANBP9,PDGFA,BTC,TEK,PPP2R5C,NRG1,PSMD11,PPP2R1B,ERBB2,FGF1,PSMD6,SHC3,PSMD2,RASGRP4,PSMD4,PSMA8,RASGRP1,SEM1,DUSP2,ACTN2,PSME4,PSMB4,FGF10,SPTB,NRAS,PSMB11
R-HSA-451927	Interleukin-2 signaling	0.0500491340550052	-2.99475007496888	262	239	0.026455612131946	9034	10285	409,2905,2668,10142,8649,6711,673,4684,8826,5711,3815,2906,10718,2248,2266,5706,10256,5713,9978,152559,64926,153090,4902,805,5684,7311,5699,26281,5595,10818,5714,816,3560,5296,4747,8452,5979,3932,5698,54518,6714,10213,5295,80824,4140,1445,7314,8822,5515,5747,2885,5906,2674,4296,5922,3718,9462,1850,2249,3567,399473,4763,1847,5516,5702,9846,5701,2261,2335,161742,2247,9965,1849,2250,5921,5526,6654,808,200734,7529,145957,84292,5682,5715,5525,7316,5159,2675,2263,10817,2069,2903,5923,2676,10197,9491,1956,1839,5777,8315,5704,2264,5291,10156,6777,2904,6464,5924,5594,5293,3568,1848,221002,5685,3717,1742,6712,5690,5686,5528,5718,2253,3562,6233,5605,5707,8682,5694,84078,3265,408,1437,9048,4233,3082,2251,28956,25780,27006,9365,2243,2260,5700,4254,3559,8660,2065,27040,5691,8074,5156,3635,54756,8437,3558,5155,7414,2066,818,2244,11221,3636,25759,5720,2254,64096,3674,100847012,1846,7450,9693,5290,5529,5719,817,2534,5693,7010,685,283455,5154,10048,3690,6708,3667,115727,5708,9861,2185,53358,2246,2064,6850,5519,3084,5527,5717,88,23198,1844,7979,10125,5710,143471,122706,4893,6710,2255,5692,8831,284,1843,6776,5695,2252,8503,5604,5623,1439,5696,57731,5536,84868,5245,801,5037,1950,6709,5687,9542,8817,5894,5518,51332,815,5786,5908,3845,3716	ARRB2,GRIN2C,GDNF,AKAP9,LAMTOR3,SPTBN1,BRAF,NCAM1,IQGAP1,PSMD5,KIT,GRIN2D,NRG3,FGF3,FGG,PSMC6,CNKSR1,PSMD7,RBX1,PAQR3,RASAL3,DAB2IP,NRTN,CALM2,PSMA3,UBA52,PSMB10,FGF20,MAPK3,FRS2,PSMD8,CAMK2B,IL2RB,PIK3R2,NEFL,CUL3,RET,LCK,PSMB9,APBB1IP,SRC,PSMD14,PIK3R1,DUSP16,MARK3,CSK,UBB,FGF17,PPP2CA,PTK2,GRB2,RAP1A,GFRA1,MAP3K11,RASA2,JAK3,RASAL2,DUSP8,FGF4,IL5,SPRED3,NF1,DUSP5,PPP2CB,PSMC3,GAB2,PSMC2,FGFR3,FN1,SPRED1,FGF2,FGF19,DUSP7,FGF5,RASA1,PPP2R5B,SOS1,CALM3,SPRED2,YWHAB,NRG4,WDR83,PSMA1,PSMD9,PPP2R5A,UBC,PDGFRB,GFRA2,FGFR2,FRS3,EREG,GRIN2A,RASGRF1,GFRA3,PSME3,PSMF1,EGFR,HBEGF,PTPN6,BRAP,PSMC4,FGFR4,PIK3CB,RASA4,STAT5B,GRIN2B,SHC1,RASGRF2,MAPK1,PIK3CD,IL5RA,DUSP6,RASGEF1A,PSMA4,JAK2,DLG4,SPTBN2,PSMB2,PSMA5,PPP2R5D,PSMD12,FGF8,IL3,RPS27A,MAP2K2,PSMD1,PEA15,PSMB6,KBTBD7,HRAS,ARRB1,CSF2,ARTN,MET,HGF,FGF6,LAMTOR2,RASGRP3,FGF22,KL,FGA,FGFR1,PSMC1,KITLG,IL2RA,IRS2,ERBB3,LAT,PSMB3,FGF23,PDGFRA,INPP5D,IL17RD,RASAL1,IL2,PDGFB,VCL,ERBB4,CAMK2G,FGB,DUSP10,INPPL1,SHC2,PSME1,FGF9,GFRA4,ITGA2B,MIR5004,DUSP4,VWF,RAPGEF2,PIK3CA,PPP2R5E,PSMD13,CAMK2D,FYN,PSMB5,TEK,BTC,KSR2,PDGFA,RANBP9,ITGB3,SPTA1,IRS1,RASGRP4,PSMD2,PSMD6,PTK2B,SHC3,FGF1,ERBB2,SYK,PPP2R1B,NRG1,PPP2R5C,PSMD11,ACTN2,PSME4,DUSP2,SEM1,RASGRP1,PSMD4,PSMA8,PSMB11,NRAS,SPTB,FGF10,PSMB4,SYNGAP1,ANGPT1,DUSP1,STAT5A,PSMB7,FGF7,PIK3R3,MAP2K1,PSPN,CSF2RB,PSMB8,SPTBN4,PPP5C,HAVCR2,PHB1,CALM1,PEBP1,EGF,SPTAN1,PSMA6,NRG2,FGF18,RAF1,PPP2R1A,SPTBN5,CAMK2A,PTPRA,RAP1B,KRAS,JAK1
R-HSA-5083635	Defective B3GALTL causes Peters-plus syndrome (PpS)	0.0501835481425936	-2.99206803224159	37	36	0.00398494576046048	9034	10285	79875,11174,92949,54437,23145,171019,9509,157869,170690,221981,170691,80731,9510,81792,11093,81794,11095,56999,9037,170689,9508,7058,9719,140766,11096,339366,57188,80070,10417,170692,54507,9507,7057,11173,10418,55901	THSD4,ADAMTS6,ADAMTSL1,SEMA5B,SSPOP,ADAMTS19,ADAMTS2,SBSPON,ADAMTS16,THSD7A,ADAMTS17,THSD7B,ADAMTS1,ADAMTS12,ADAMTS13,ADAMTS10,ADAMTS8,ADAMTS9,SEMA5A,ADAMTS15,ADAMTS3,THBS2,ADAMTSL2,ADAMTS14,ADAMTS5,ADAMTSL5,ADAMTSL3,ADAMTS20,SPON2,ADAMTS18,ADAMTSL4,ADAMTS4,THBS1,ADAMTS7,SPON1,THSD1
R-HSA-176187	Activation of ATR in response to replication stress	0.0501835481425936	-2.99206803224159	37	36	0.00398494576046048	9034	10285	6119,23595,4999,5883,4175,23594,63967,993,4171,5000,55388,84126,1111,5983,4174,5982,10926,1017,8317,5884,3364,545,5985,84515,6118,4998,6117,5984,5001,4172,995,4173,144715,990,5810,8318	RPA3,ORC3,ORC2,RAD9A,MCM6,ORC6,CLSPN,CDC25A,MCM2,ORC4,MCM10,ATRIP,CHEK1,RFC3,MCM5,RFC2,DBF4,CDK2,CDC7,RAD17,HUS1,ATR,RFC5,MCM8,RPA2,ORC1,RPA1,RFC4,ORC5,MCM3,CDC25C,MCM4,RAD9B,CDC6,RAD1,CDC45
R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	0.0504732755823121	-2.98631127916451	23	23	0.00254593756918309	9034	10285	51109,222236,157506,7276,6121,9227,5949,6010,24,50700,64220,5959,5950,121214,6017,5947,3292,8608,285440,8630,10170,4647,145226	RDH11,NAPEPLD,RDH10,TTR,RPE65,LRAT,RBP3,RHO,ABCA4,RDH8,STRA6,RDH5,RBP4,SDR9C7,RLBP1,RBP1,HSD17B1,RDH16,CYP4V2,HSD17B6,DHRS9,MYO7A,RDH12
R-HSA-5654693	FRS-mediated FGFR1 signaling	0.0504732755823121	-2.98631127916451	23	23	0.00254593756918309	9034	10285	26281,9365,2255,27006,10818,2260,3845,4893,2885,2249,10817,2251,8822,5781,2254,2248,3265,2246,2250,6654,2247,8074,2253	FGF20,KL,FGF10,FGF22,FRS2,FGFR1,KRAS,NRAS,GRB2,FGF4,FRS3,FGF6,FGF17,PTPN11,FGF9,FGF3,HRAS,FGF1,FGF5,SOS1,FGF2,FGF23,FGF8
R-HSA-168249	Innate Immune System	0.0506049885576047	-2.98370511945325	1285	1147	0.126964799645783	9034	10285	79169,25852,1511,5534,177,80341,5441,100500842,3265,7187,8398,3310,196883,441864,963,5707,5567,2517,823,8987,4048,2251,25780,81567,5700,4208,192670,400709,79980,408,10462,718,3656,23197,818,51135,155066,10010,5720,5049,2244,2799,2065,3385,8074,161,1540,114548,8660,4773,644414,245973,1759,29851,6727,3106,246330,3809,8411,8915,3075,64096,100847012,1116,23239,9693,8566,53358,5581,22954,115727,7462,51125,10910,5519,196051,30849,1147,2665,1793,4772,727,9218,147179,3690,114,10096,10878,596,3579,5236,684,245908,942,5284,4615,192669,203068,3240,7295,2220,5305,79132,51191,8778,940,57731,1843,258010,4790,122618,5775,3346,533,2357,5518,149954,54210,4775,2040,967,55276,2207,1669,4680,5337,5687,302,8817,5894,55615,6518,5648,7706,3101,2906,5711,3815,60,7128,10718,329,9961,6993,10142,4684,150372,8826,6711,3146,351,7879,5684,5577,8976,5595,6386,2033,71,1535,5699,84513,57161,5137,2204,245928,100293534,152559,4343,23412,4902,842,1499,4193,1471,5698,50856,1026,6280,90423,528,3443,26999,100500827,10213,1520,4747,2495,4125,7456,5788,9462,2950,5747,5922,10094,3004,5266,84265,4763,11001,55004,53917,51231,3848,3689,30835,5608,3442,160364,5970,55754,5525,55703,7529,10768,2247,3728,9846,3665,1650,3709,9447,5873,10392,10817,245940,998,2263,284266,5724,5478,5923,10197,138050,56729,5159,55845,2675,11240,391,112,27327,51728,115004,5704,3326,10156,245938,83737,1823,1956,114771,613210,10747,417,100616211,83858,8936,6195,8315,55600,966,11322,1476,5036,1742,80301,5530,11333,5609,55860,3568,5170,23526,57162,6406,7077,3445,4318,3708,6036,221002,51295,23200,7099,3449,3725,9208,10562,5553,5528,3702,5058,3562,23586,5605,717,5023,178,5136,3082,79837,10487,1675,6199,51552,27006,1938,10333,100847079,55,338324,3683,290,5576,5971,3163,1437,7318,9048,5155,140881,7414,196527,10584,8992,210,78989,1514,2932,613211,114770,221,1027,526,23545,5315,1672,941,5693,9145,817,6286,3448,7098,57115,93978,5602,2254,5768,5529,118430,727897,102,140885,7525,7450,4361,2246,2268,3916,8993,1072,3685,5717,1265,9545,11213,6850,84335,685,330,10071,115,5603,6710,353376,9252,5692,728,5598,23198,5878,1191,5710,2760,671,143471,55313,5005,5623,4153,64145,5536,968,1991,10890,8655,23112,1385,5879,4064,5599,8503,5695,7334,10321,109,29099,23317,2990,11314,197358,3320,5908,23646,3845,6037,713,1828,63916,5037,117159,7249,1950,7130,1075,122665,5245,201294,5806,567,51082,148022,9542,64333,5153,29110,64127,170482,401258,10970,4353,4067,5706,23071,5566,79930,56888,2668,118788,6885,8649,245927,7322,3614,2683,10163,79109,9636,10623,8772,10818,716,100847046,51517,64926,7305,140453,374395,1604,10256,199675,10097,5328,10458,5580,1326,3932,5295,10892,1088,111,1235,6714,475,54941,816,3551,5223,5714,5329,9844,10695,427,6778,11128,6515,6416,23385,3718,4791,3304,387921,399473,1378,3107,1445,80824,3428,79155,5515,1729,10043,387,808,200734,997,27180,8945,613209,11010,8395,79888,145957,253260,945,383,2335,523,5912,5701,9450,2250,1849,8560,9103,837,2214,2069,3837,114790,58484,9491,7410,7276,4846,5440,4205,8804,3452,598,10855,81030,566,84766,3347,2904,841,10622,5660,79671,5869,9522,5336,10454,8773,5686,8454,9261,57690,7323,54472,1848,2547,10000,5293,2588,917,57554,23352,3133,466,2206,5611,5694,7335,8682,7226,22914,2253,1915,725,5434,10326,730,5004,6233,2209,1667,9039,23643,28956,8904,5799,3559,9365,2720,1660,4585,1513,272,4689,3937,388697,4233,25797,2066,5062,3558,27202,3439,64114,27040,5663,3684,3577,644150,51411,338339,4688,54756,3164,529,57761,2534,830,81622,10006,127829,208,965,5338,11277,1398,171568,30,2919,3105,353189,732,629,5290,9533,222487,2358,1846,5582,5568,84659,353,175,411,6616,23593,5708,10577,59307,3084,23406,4583,1515,7010,10787,10109,317,283455,81623,10048,5154,7415,6708,714,64135,8737,2255,535,1778,26007,10875,3903,653361,10125,5604,9535,9436,10628,22918,284,976,3958,1113,55832,814,5094,2252,51316,7189,10451,5728,7867,3716,2519,6709,3608,84418,5273,130120,81619,801,919,9246,3426,47,3071,94025,1512,2934,245909,57119,56667,2266,57506,147945,1785,143662,2212,245913,2248,4179,27297,2905,23114,409,3661,1670,3417,57153,3482,719,245915,834,245911,124599,11035,805,3824,948,7311,26281,5600,23250,84329,5713,53831,153090,23220,4627,54518,8452,50617,5979,8972,6317,4126,7520,1432,128859,26578,9140,5317,27161,170506,8394,3560,8767,2249,1850,9725,245929,64223,5906,4831,80142,4317,23191,3567,4033,56954,4620,92747,8822,3441,7133,5627,340061,5265,2215,8621,1508,4644,3687,54509,5715,9588,84292,932,6402,161742,80143,2261,5211,64581,8870,5921,5526,9965,5289,2992,5027,1315,5591,26,2676,8895,2903,10810,10095,7316,5578,51806,961,10450,712,51382,5836,7100,6196,6464,23118,23601,4690,55718,1839,1387,140850,51143,26523,6836,107,140683,6712,84282,7096,54476,3934,100302237,127124,6288,4651,1509,100049587,5690,9641,930,8907,5787,7409,3615,23396,10578,6590,84078,6282,51816,1522,5606,1084,327,388698,26052,5870,4210,84514,5718,6039,81844,10552,10788,4282,10120,4718,81793,2260,5575,4254,2171,8514,2243,226,1992,4973,54106,2444,728358,8437,114609,8836,11221,207,51719,200958,25759,2896,25,5691,5156,1832,4650,10093,10394,9798,2475,5657,10533,8651,7294,22875,83716,80331,197,2821,843,3674,5781,3043,116842,5719,929,8288,1401,9861,116844,10235,5527,731,634,2064,3384,2219,5269,117145,26253,5601,245972,84166,5573,245930,57020,3667,715,847,6556,8635,1671,245910,122706,4893,51606,28988,3660,51071,5532,3074,10092,2931,3643,1844,22861,7979,88,7157,240,8876,24145,920,4057,6500,54918,5175,326624,3440,1386,25798,6283,1439,387263,5864,5696,8831,400830,79792,10312,11031,4311,815,51332,683,8673,5786,113,1794,7097,9474,124583,2549,5834,9051,6947,10576,673,4860,84433,835,960,3444,820,64386,6737,722,1143,9978,22931,23218,2308,3984,25840,51646,50852,9114,2309,3136,3312,720,5296,735,4793,2353,342510,3553,100528032,2885,2674,4296,5516,5702,2512,3630,1847,58485,51297,2548,4140,5646,23035,729230,338,7314,6793,9761,9550,5682,1727,8887,9020,2352,5588,4792,9402,5320,3929,10396,729,5547,8396,23291,6654,10694,12,6279,154664,5068,4588,4332,661,156,4589,89777,29108,2264,5291,5924,3710,978,3093,6278,10152,4641,4842,3456,5795,5777,3659,121260,7321,525,394263,6300,5641,2205,80184,25801,84658,5335,4257,5300,5594,4069,1118,108,4214,4758,5685,3717,79895,5589	C1orf35,ARMC8,CTSG,PPP3R1,AGER,BPIFB2,POLR2L,MIR3652,HRAS,TRAF3,PLA2G6,HSPA6,ADCY4,TARM1,CD53,PSMD1,PRKACB,FUCA1,CAPN1,STBD1,LTA4H,FGF6,RASGRP3,TXNDC5,PSMC1,MEF2C,AGO4,SIGLEC16,DSN1,ARRB1,CLEC10A,C3,IRAK2,FAF2,CAMK2G,IRAK4,ATP6V0E2,TANK,PSME1,PAFAH1B2,FGB,GNS,ERBB3,ICAM3,FGF23,AP2A2,CYLD,NLRP3,IRS2,NFATC2,DEFB131A,ATP6V1C2,DNM1,ICOS,SRP14,HLA-B,PELI3,KIR2DS4,EEA1,BCL10,CFH,GFRA4,MIR5004,CHI3L1,PHLPP1,RAPGEF2,PDXK,SHC3,PRKCE,TRIM32,RASGRP4,LAT2,GOLGA7,SUGT1,PPP2R1B,PLPP4,PIK3R4,CHUK,GDI2,DOCK1,NFATC1,C5,VAPA,WIPF2,ITGB3,ADCY8,ACTR3,CFHR3,BCL2,CXCR2,PGM1,BST2,DEFB105A,CD86,PIGR,MYD88,AGO3,TUBB,HP,TXN,FCN2,PIP4K2A,DHX58,HERC5,SIGLEC5,CD28,SPTBN4,DUSP1,SVIP,NFKB1,PLD4,PTPN4,HTN1,ATP6V0B,FPR1,PPP2R1A,BPIFB4,TREM1,NFATC3,STOM,CD63,PGM2,FCER1G,DEFA4,CEACAM6,PLD1,PSMA6,ANXA2,FGF18,RAF1,PRR5,SLC2A5,MASP1,TRIM25,HK3,GRIN2D,PSMD5,KIT,ACTB,TNFAIP3,NRG3,BIRC2,MVP,DYNLT1,AKAP9,NCAM1,NFAM1,IQGAP1,SPTBN1,HMGB1,APP,RAB7A,PSMA3,PRKAR2B,WASL,MAPK3,SDCBP,EP300,ACTG1,CYBA,PSMB10,PLPP5,PELI2,PDE1C,FCAR,DEFB114,C4B_2,PAQR3,MOV10,COMMD3,NRTN,CASP9,CTNNB1,MDM2,CST3,PSMB9,CLEC4A,CDKN1A,S100A9,ATP6V1E2,ATP6V1C1,IFNA6,CYFIP2,MIR3614,PSMD14,CTSS,NEFL,FTH1,MAN2B1,WIPF1,PTPRC,RASAL2,GSTP1,PTK2,RASA2,ARPC3,GZMM,PI3,POLR3GL,NF1,SLC27A2,LAMTOR1,RAB24,VRK3,KRT1,ITGB2,CD209,MAP2K6,IFNA5,CLEC12A,RELA,TMEM30A,PPP2R5A,POLR3B,YWHAB,AHCYL1,FGF2,JUP,GAB2,IRF7,DDOST,ITPR2,AIM2,RAB27A,NOD1,FRS3,DEFB130A,CDC42,FGFR2,SIGLEC15,PTAFR,PPIA,RASGRF1,PSME3,HGSNAT,RETN,PDGFRB,BRK1,GFRA2,PADI2,RHOG,ADCY6,TNRC6A,POLR3K,CGAS,PSMC4,HSP90AB1,RASA4,DEFB125,ITCH,DSC1,EGFR,PGLYRP3,DEFB136,MASP2,ART1,MIR4709,ATAD3B,WASF1,RPS6KA1,BRAP,ITLN1,CD59,TMC6,CSTB,PA2G4,DLG4,PLEKHO2,PPP3CA,PDAP1,MAP2K7,ACTR10,IL5RA,PDPK1,ARHGAP45,PELI1,SEMG1,TIMP2,IFNA8,MMP9,ITPR1,RNASE2,RASGEF1A,ECSIT,ATP11B,TLR4,IFNA16,JUN,LRRFIP1,OLFM4,PRG2,PPP2R5D,ITK,PAK1,IL3,RIGI,MAP2K2,C2,P2RX1,AGL,PDE1A,HGF,PIP4K2C,CAP1,CFD,RPS6KB2,RAB14,FGF22,EEF2,TLR6,MIR5193,ACP3,S100A7A,ITGAL,ANPEP,PRKAR2A,RELB,HMOX2,CSF2,UBA7,ARTN,PDGFB,DEFB129,VCL,ANO6,COLEC10,ATP6V0E1,ALAD,COLEC11,CTSL,GSK3B,DEFB134,PGLYRP2,ALDH3B1,CDKN1B,ATP6V1B2,ATP6V0A2,PKM,DEFB1,CD80,PSMB5,SYNGR1,CAMK2D,S100P,IFNA14,TLR3,PGLYRP4,CLEC6A,MAPK10,FGF9,QSOX1,PPP2R5E,MUCL1,MUC5B,ADAM10,SIRPA,YES1,VWF,MRE11,FGF1,FGR,LAMP1,PGLYRP1,CFL1,ITGAV,PSMD11,CNN2,RAB3D,IRAK3,SYK,AKT1S1,BTC,BIRC3,MUC12,ADCY9,MAPK13,SPTB,TICAM2,RPS6KA5,PSMB4,C5AR1,MAPK7,PSME4,RAB5C,CLU,PSMD4,GM2A,BPI,PSMA8,CPPED1,ORM2,PSPN,MBL2,RBSN,PPP5C,CD68,ELANE,RAB10,DYNLL1,TNRC6B,CREB1,RAC1,CD180,MAPK8,PIK3R3,PSMB7,UBE2N,CRISP3,ADCY3,COMMD9,DNAJC13,GUSB,CD300A,NLRC3,HSP90AA1,RAP1B,PLD3,KRAS,RNASE3,C1QB,DSG1,ELMO2,PEBP1,DCD,TSC2,EGF,TNFAIP6,CTSC,RNASE8,PHB1,UNC13D,PTX3,B2M,POLR1D,TICAM1,NRG2,ARHGAP9,PDE1B,TBK1,NOD2,CLEC4C,RAB44,CKAP4,MPO,LYN,PSMC6,ERP44,PRKACA,DOK3,KCMF1,GDNF,PIK3AP1,MAP3K7,LAMTOR3,DEFB113,UBE2D2,IMPDH1,B4GALT1,WASF2,MAPKAP1,ISG15,POLR3C,FADD,FRS2,C1S,MIR5010,NCKIPSD,RASAL3,TYROBP,MUC17,TMEM179B,CD55,CNKSR1,MCEMP1,ACTR2,PLAU,BAIAP2,PRKCD,MAP3K8,LCK,PIK3R1,MALT1,CEACAM8,ADCY5,CCR6,SRC,ATOX1,RNF125,CAMK2B,IKBKB,PGAM1,PSMD8,PLAUR,ELMO1,CNPY3,ASAH1,STAT6,POLR3A,SLC2A3,MAP2K4,NCSTN,JAK3,NFKB2,HSPA1B,NHLRC3,SPRED3,CR1,HLA-C,CSK,DUSP16,IFI16,TNIP2,PPP2CA,DIAPH1,TOM1,RHOA,CALM3,SPRED2,CDC34,SIGLEC9,BTRC,DEFB135,GLIPR1,PIP5K1B,LPCAT1,NRG4,RICTOR,CD33,ARG1,FN1,ATP6V1A,RAP2B,PSMC2,LY86,FGF5,DUSP7,DEGS1,FCGR2C,CASP4,FCGR3A,EREG,KPNB1,STK11IP,NLRC4,PSMF1,VAV2,TTR,NOS3,POLR2K,MEF2A,CREG1,IFNA21,BCL2L1,HPSE,ZBP1,AZU1,CRACR2A,HTN3,GRIN2B,CASP8,POLR3G,PSAP,NLRX1,RAB5B,SCAMP1,PLCG2,TAB1,SNAP23,PSMA5,CUL1,MAPKAPK2,TNRC6C,UBE2D3,TOLLIP,DUSP6,XRCC6,AKT3,PIK3CD,GALNS,CD3G,LRRC7,UBR4,HLA-E,ATF1,MS4A2,DNAJC3,PSMB6,UBE2V1,PEA15,TRPM2,KLRK1,FGF8,EEF1A1,C4BPB,POLR2E,SIRPB1,C7,ORM1,RPS27A,FCGR1A,DEFA1,UBA3,LY96,LAMTOR2,CPNE1,PTPRN2,IL2RA,KL,GLB1,DHX9,MUC4,CTSK,AMPD3,NCF4,LCP2,HRNR,MET,QPCT,ERBB4,PAK2,IL2,C5AR2,IFNA1,TMBIM1,LAT,PSEN1,ITGAM,CXCR1,WIPF3,BIN2,CLEC4D,NCF2,IL17RD,NR4A1,ATP6V1E1,TRIB3,FYN,CAPZA2,UNC93B1,ABI1,ARL8A,AKT2,CD58,PLD2,TREX1,CRK,POLR3H,ACAA1,CXCL1,HLA-A,SLCO4C1,C8B,CFB,PIK3CA,POLR1C,ADGRG3,FPR2,DUSP4,PRKCG,PRKACG,RNASE7,APRT,AGA,ARSB,SNAP25,HEBP2,PSMD2,NPC2,SIGIRR,NRG1,COTL1,MUC2,CTSV,TEK,NCKAP1,ARPC2,APAF1,KSR2,DEFB126,RANBP9,PDGFA,VCP,SPTA1,C1QC,IFIH1,RIPK1,FGF10,ATP6V0A1,DYNC1H1,TKFC,FGL2,LAIR1,NCF1,RASGRP1,MAP2K1,GMFG,NCR2,TXNIP,CD93,ANGPT1,ADGRE5,LGALS3,CHGA,CAND1,CAMK4,PCBP2,FGF7,PLAC8,TRAF6,VAV3,PTEN,MAPKAPK3,JAK1,FUCA2,SPTAN1,ILF2,CYSTM1,SERPINB10,REG3G,TSPAN14,CALM1,CD247,UBE2L6,CFI,ACLY,NCKAP1L,MUC16,CTSH,GSN,DEFB106A,EPPIN,MUC13,FGG,MAVS,NLRP4,DNM2,MUC15,FCGR2A,DEFB110,FGF3,CD46,CRCP,GRIN2C,NFASC,ARRB2,IRF3,DEFA5,IDH1,SLC44A2,IGF2R,C3AR1,DEFB112,CASP1,DEFB108B,CD300LB,RIPK3,CALM2,KLRD1,CD36,UBA52,FGF20,MAPK11,ATP11A,HVCN1,PSMD7,GPR84,DAB2IP,DTX4,MYH9,APBB1IP,CUL3,ATP6V0A4,RET,MGAM,SERPINB3,MANBA,XRCC5,MAPK14,BPIFB6,OSTF1,ATG12,PKP1,AGO2,DHX36,PIP5K1A,IL2RB,RIPK2,FGF4,DUSP8,TMEM63A,DEFB115,MLST8,RAP1A,NME2,PTGES2,MMP8,CYFIP1,IL5,IRAG2,NIT2,MYH2,BPIFB1,FGF17,IFNA4,TNFRSF1B,PROS1,STING1,SERPINA1,FCGR3B,CDK13,CTSB,MYO5A,ITGAX,RHOF,PSMD9,PRDX6,WDR83,MS4A3,SELL,SPRED1,SIKE1,FGFR3,PFKL,CLEC7A,IER3,RASA1,PPP2R5B,FGF19,PIK3C3,GYG1,P2RX7,COPB1,PRKDC,AOC1,GFRA3,CPNE3,GRIN2A,WASF3,ARPC1B,UBC,PRKCA,CALML5,CD47,PPIE,C1QA,ATP6V1D,PYGL,TLR5,RPS6KA2,SHC1,TAB2,CLEC5A,NCK1,POLR3E,HBEGF,CREBBP,DEFB127,DYNC1LI1,AGO1,SURF4,ADCY1,BPIFA2,SPTBN2,RNF135,TLR1,RNF216,LCN2,MIR1281,ATP6V1G3,SAA1,MYO10,CTSD,SIGLEC14,PSMB2,IKBKE,CD19,AP1M1,PTPRB,VAV1,IMPDH2,PIP5K1C,GNLY,SLPI,KBTBD7,S100A11,ADA2,CTSZ,MAP2K3,CEACAM3,APEH,FLG2,DNM3,RAB6A,MEFV,GHDC,PSMD12,RNASE6,TRIM56,ARPC1A,IQGAP2,MIF,ACTR1B,NDUFC2,TLR10,FGFR1,PRKAR1B,KITLG,FABP5,KCNAB2,FGA,ALDOA,SERPINB1,OLR1,TLR9,FRK,DEFA1B,RASAL1,TIRAP,GGH,DUSP10,AKT1,CAB39,MUC20,SHC2,GRN,ABL1,PSMB3,PDGFRA,DSP,MYO9B,ARPC4,PRG3,IST1,MTOR,PRTN3,ATG7,SOCS1,TXK,ENPP4,CRISPLD2,DNAJC5,AHSG,GPI,CASP10,ITGA2B,PTPN11,HBB,LEAP2,PSMD13,CD14,EPX,CRP,PSMD6,LRG1,RASGRP2,PPP2R5C,C8A,CEACAM1,ERBB2,ICAM2,FCN1,SERPINB6,THEM4,CLEC4E,MAPK9,ATP6V0D2,NLRC5,PRKAR1A,DEFB116,VPS35L,IRS1,C1R,CAT,SLC11A1,RNASET2,DEFA6,DEFB107A,PSMB11,NRAS,ATP6V1H,DBNL,IRF2,DERA,PPP3CB,HEXB,ARPC5,GSK3A,INSR,DUSP2,NLRP1,SEM1,ACTN2,TP53,ALOX5,VNN1,PANX1,CD4,LTF,SKP1,CMTM6,PECAM1,RAB37,IFNA2,ATF2,BRI3,S100A12,CSF2RB,C6orf120,RAB3A,PSMB8,SYNGAP1,DEFB132,GSDMD,TCIRG1,RAB31,MME,CAMK2A,SPTBN5,BST1,VAMP8,PTPRA,ADCY7,DOCK2,TLR2,ATG5,CANT1,GAB1,PYGB,PSTPIP1,TCN1,CCT2,BRAF,PNP,CARD11,CASP2,CD44,IFNA7,CAMP,MMP25,TRIM21,C4BPA,CHRNB4,RBX1,RAB18,NBEAL2,FOXO1,LIMK1,TMT1A,YPEL5,TRAT1,ATP6V0D1,FOXO3,HLA-H,HSPA8,C4A,PIK3R2,C9,NFKBIB,FOS,CD300E,IL1B,KLRC4-KLRK1,GRB2,GFRA1,MAP3K11,PPP2CB,PSMC3,FTL,INS,DUSP5,TRAPPC1,BPIFA1,GAA,MARK3,PRSS3,PHLPP2,CCR2,APOB,UBB,STK10,MLEC,ATP6V1G1,PSMA1,CYB5R3,TAX1BP1,MAP3K14,FOLR3,PRKCQ,NFKBIA,GRAP2,PLA2G2A,LBP,ATP8A1,C6,PRCP,PIP4K2B,FBXW11,SOS1,CCT8,SERPINA3,S100A8,ABCA13,REG3A,MUC6,MNDA,POLR3D,GRK2,MUC7,SERPINB12,PYCARD,FGFR4,PIK3CB,RASGRF2,ITPR3,CDA,UBE2K,S100A7,ABI2,MYO1C,NOS1,IFNB1,PTPRJ,PTPN6,IRF1,SLC15A4,UBE2D1,ATP6V1B1,MUC21,MAPK12,LGMN,FCER1A,CEP290,GCA,ADGRE3,PLCG1,MGST1,PIN1,MAPK1,LYZ,CHIT1,ADCY2,MAP3K1,NEU1,PSMA4,JAK2,ATP8B4,PRKCSH
R-HSA-4086398	Ca2+ pathway	0.0508835394016086	-2.97821579865885	61	58	0.006420190391853	9034	10285	5578,192669,2791,1499,2535,4343,2783,805,6932,192670,5532,2780,5593,4772,8323,7474,23236,3709,2787,6885,2788,5534,808,6934,2793,2790,2786,83439,801,3708,10681,51176,59345,5145,51764,5331,815,7481,5148,57690,5530,2782,27161,23112,7976,7855,94235,5158,26523,54331,8322,55970,5592,2784,5330,27327,2792,3710	PRKCA,AGO3,GNG11,CTNNB1,FZD2,MOV10,GNB2,CALM2,TCF7,AGO4,PPP3CB,GNAT2,PRKG2,NFATC1,FZD6,WNT5A,PLCB1,ITPR2,GNG5,MAP3K7,GNG7,PPP3R1,CALM3,TCF7L2,GNGT2,GNG10,GNG4,TCF7L1,CALM1,ITPR1,GNB5,LEF1,GNB4,PDE6A,GNG13,PLCB3,CAMK2A,WNT11,PDE6G,TNRC6C,PPP3CA,GNB1,AGO2,TNRC6B,FZD3,FZD5,GNG8,PDE6B,AGO1,GNG2,FZD4,GNG12,PRKG1,GNB3,PLCB2,TNRC6A,GNGT1,ITPR3
R-HSA-8853659	RET signaling	0.0533947818567403	-2.93004225582928	270	246	0.02723046269648	9034	10285	200734,808,7529,145957,84292,5715,5525,5682,5701,9846,2261,2335,161742,2247,9965,1849,2250,5921,6654,5526,2263,2069,10817,2903,5923,9491,2676,10197,5578,9046,7316,5159,220164,2675,5704,10156,5291,2264,55715,2904,5924,6464,1839,1956,8315,1742,6712,5690,5686,5335,5293,5594,3568,1848,221002,3717,5685,5711,3815,2906,2549,5566,10718,2248,2266,5706,409,2668,10142,2905,6711,8649,4684,673,8826,805,5684,7311,26281,5699,5595,10818,5713,10256,152559,9978,64926,153090,4902,5979,8452,5698,54518,6714,10213,5295,5714,816,3560,5296,4747,5906,2885,2674,5747,3718,5922,4296,9462,1850,2249,399473,3567,1847,4763,5516,5702,80824,4140,1445,7314,5515,8822,5909,115727,5708,53358,5568,9861,2246,2064,5519,5717,3084,5527,7010,685,10048,5154,283455,6708,3690,3667,122706,4893,6710,2255,5692,23198,5598,88,1844,7979,10125,143471,5710,5604,5623,1439,57731,5696,5536,8831,284,1843,5695,2252,8503,5518,815,51332,55816,5786,3845,5908,3716,5245,801,5037,1950,6709,8817,9542,5687,5894,8682,5694,84078,3265,5718,5528,2253,6233,5605,5567,3562,5707,3082,25780,2251,28956,2243,27006,9365,2260,4254,3559,5700,408,1437,9048,1796,4233,8437,3558,5155,2066,818,7414,11221,2244,25759,5720,8660,8074,27040,5691,2065,9260,5156,54756,817,2887,5693,2534,3674,100847012,64096,2254,5781,7450,1846,9693,5290,5719,5529	SPRED2,CALM3,YWHAB,NRG4,WDR83,PSMD9,PPP2R5A,PSMA1,PSMC2,GAB2,FGFR3,FN1,SPRED1,FGF2,FGF19,DUSP7,FGF5,RASA1,SOS1,PPP2R5B,FGFR2,EREG,FRS3,GRIN2A,RASGRF1,PSMF1,GFRA3,PSME3,PRKCA,DOK2,UBC,PDGFRB,DOK6,GFRA2,PSMC4,RASA4,PIK3CB,FGFR4,DOK4,GRIN2B,RASGRF2,SHC1,HBEGF,EGFR,BRAP,DLG4,SPTBN2,PSMB2,PSMA5,PLCG1,PIK3CD,MAPK1,IL5RA,DUSP6,RASGEF1A,JAK2,PSMA4,PSMD5,KIT,GRIN2D,GAB1,PRKACA,NRG3,FGF3,FGG,PSMC6,ARRB2,GDNF,AKAP9,GRIN2C,SPTBN1,LAMTOR3,NCAM1,BRAF,IQGAP1,CALM2,PSMA3,UBA52,FGF20,PSMB10,MAPK3,FRS2,PSMD7,CNKSR1,PAQR3,RBX1,RASAL3,DAB2IP,NRTN,RET,CUL3,PSMB9,APBB1IP,SRC,PSMD14,PIK3R1,PSMD8,CAMK2B,IL2RB,PIK3R2,NEFL,RAP1A,GRB2,GFRA1,PTK2,JAK3,RASA2,MAP3K11,RASAL2,DUSP8,FGF4,SPRED3,IL5,DUSP5,NF1,PPP2CB,PSMC3,DUSP16,MARK3,CSK,UBB,PPP2CA,FGF17,RAP1GAP,RASGRP4,PSMD2,SHC3,PRKACG,PSMD6,FGF1,ERBB2,PPP2R1B,PSMD11,NRG1,PPP2R5C,TEK,BTC,RANBP9,PDGFA,KSR2,SPTA1,ITGB3,IRS1,PSMB11,NRAS,SPTB,FGF10,PSMB4,PSME4,MAPK7,ACTN2,DUSP2,SEM1,RASGRP1,PSMA8,PSMD4,MAP2K1,PSPN,CSF2RB,SPTBN4,PSMB8,PPP5C,SYNGAP1,ANGPT1,DUSP1,PSMB7,FGF7,PIK3R3,PPP2R1A,CAMK2A,SPTBN5,DOK5,PTPRA,KRAS,RAP1B,JAK1,PHB1,CALM1,PEBP1,EGF,SPTAN1,FGF18,NRG2,PSMA6,RAF1,PEA15,PSMB6,KBTBD7,HRAS,PSMD12,PPP2R5D,FGF8,RPS27A,MAP2K2,PRKACB,IL3,PSMD1,HGF,RASGRP3,FGF6,LAMTOR2,FGA,FGF22,KL,FGFR1,KITLG,IL2RA,PSMC1,ARRB1,CSF2,ARTN,DOK1,MET,RASAL1,IL2,PDGFB,ERBB4,CAMK2G,VCL,DUSP10,FGB,SHC2,PSME1,IRS2,FGF23,LAT,PSMB3,ERBB3,PDLIM7,PDGFRA,IL17RD,CAMK2D,GRB10,PSMB5,FYN,ITGA2B,MIR5004,GFRA4,FGF9,PTPN11,VWF,DUSP4,RAPGEF2,PIK3CA,PSMD13,PPP2R5E
R-HSA-5684996	MAPK1/MAPK3 signaling	0.0536547599493452	-2.92518509157922	251	229	0.0253486827540403	9034	10285	8660,5156,2065,5691,8074,27040,54756,3558,8437,7414,818,2066,5155,25759,2244,11221,5720,5781,2254,64096,100847012,3674,9693,1846,7450,5719,5529,817,2534,5693,3570,5718,5528,2253,3562,5605,6233,5707,8682,84078,5694,3265,408,9048,1437,4233,3082,2251,25780,28956,9365,27006,2243,5700,3559,4254,2260,284,8831,1843,2252,5695,5623,5604,5696,57731,1439,5536,801,5245,6709,1950,5037,5894,5687,9542,8817,51332,815,5518,983,5786,3716,5908,3845,685,7010,3690,6708,283455,10048,5154,3667,5708,115727,2246,9861,53358,2064,5527,5717,3084,5519,88,23198,7979,1844,10125,5710,143471,122706,4893,6710,5692,2255,5714,816,3560,4747,8452,5979,5698,54518,10213,6714,80824,1445,4140,7314,8822,5515,4296,5922,3718,5747,2885,2674,5906,1850,2249,9462,4763,1847,3567,399473,5702,5516,409,2905,10142,2668,8649,6711,8826,673,4684,3815,5711,2906,2248,10718,5706,2266,9978,152559,10256,5713,64926,153090,4902,5684,805,5699,26281,7311,5595,10818,3572,1956,1839,8315,2264,10156,5704,2904,6464,5924,5594,1848,3568,5685,3717,221002,6712,1742,5690,5686,2261,5701,2247,161742,2335,1849,2250,9965,3569,5526,6654,5921,808,200734,84292,7529,145957,5682,5525,5715,5159,7316,7297,2675,2263,10817,2069,2903,10197,2676,9491,5923	IRS2,PDGFRA,ERBB3,PSMB3,FGF23,LAT,IL17RD,IL2,RASAL1,VCL,CAMK2G,ERBB4,PDGFB,SHC2,FGB,DUSP10,PSME1,PTPN11,FGF9,GFRA4,MIR5004,ITGA2B,RAPGEF2,DUSP4,VWF,PSMD13,PPP2R5E,CAMK2D,FYN,PSMB5,IL6R,PSMD12,PPP2R5D,FGF8,IL3,MAP2K2,RPS27A,PSMD1,PEA15,KBTBD7,PSMB6,HRAS,ARRB1,ARTN,CSF2,MET,HGF,FGF6,RASGRP3,LAMTOR2,KL,FGF22,FGA,PSMC1,IL2RA,KITLG,FGFR1,ANGPT1,SYNGAP1,DUSP1,FGF7,PSMB7,PSPN,MAP2K1,PSMB8,SPTBN4,CSF2RB,PPP5C,CALM1,PHB1,SPTAN1,EGF,PEBP1,RAF1,PSMA6,NRG2,FGF18,SPTBN5,CAMK2A,PPP2R1A,CDK1,PTPRA,JAK1,RAP1B,KRAS,BTC,TEK,ITGB3,SPTA1,KSR2,RANBP9,PDGFA,IRS1,PSMD2,RASGRP4,FGF1,PSMD6,SHC3,ERBB2,PPP2R5C,PSMD11,NRG1,PPP2R1B,ACTN2,PSME4,SEM1,DUSP2,RASGRP1,PSMD4,PSMA8,PSMB11,NRAS,SPTB,PSMB4,FGF10,PSMD8,CAMK2B,IL2RB,NEFL,CUL3,RET,PSMB9,APBB1IP,PSMD14,SRC,DUSP16,CSK,MARK3,UBB,FGF17,PPP2CA,MAP3K11,RASA2,JAK3,PTK2,GRB2,GFRA1,RAP1A,DUSP8,FGF4,RASAL2,NF1,DUSP5,IL5,SPRED3,PSMC3,PPP2CB,ARRB2,GRIN2C,AKAP9,GDNF,LAMTOR3,SPTBN1,IQGAP1,BRAF,NCAM1,KIT,PSMD5,GRIN2D,FGF3,NRG3,PSMC6,FGG,RBX1,PAQR3,CNKSR1,PSMD7,RASAL3,DAB2IP,NRTN,PSMA3,CALM2,PSMB10,FGF20,UBA52,MAPK3,FRS2,IL6ST,EGFR,HBEGF,BRAP,FGFR4,RASA4,PSMC4,GRIN2B,SHC1,RASGRF2,MAPK1,DUSP6,IL5RA,PSMA4,JAK2,RASGEF1A,SPTBN2,DLG4,PSMB2,PSMA5,FGFR3,PSMC2,FGF2,SPRED1,FN1,DUSP7,FGF5,FGF19,IL6,PPP2R5B,SOS1,RASA1,CALM3,SPRED2,WDR83,YWHAB,NRG4,PSMA1,PPP2R5A,PSMD9,PDGFRB,UBC,TYK2,GFRA2,FGFR2,FRS3,EREG,GRIN2A,PSME3,GFRA3,PSMF1,RASGRF1
R-HSA-177243	Interactions of Rev with host cellular proteins	0.0558619957341588	-2.88487099167477	36	35	0.00387425282266991	9034	10285	23279,5902,348995,23511,100101267,23636,23165,5903,10762,57122,7514,55746,79902,23225,9972,53371,4869,8021,9883,79023,3837,4927,1104,7175,4928,5905,9818,129401,8086,11097,9688,5901,55706,9631,81929	NUP160,RANBP1,NUP43,NUP188,POM121C,NUP62,NUP205,RANBP2,NUP50,NUP107,XPO1,NUP133,NUP85,NUP210,NUP153,NUP54,NPM1,NUP214,POM121,NUP37,KPNB1,NUP88,RCC1,TPR,NUP98,RANGAP1,NUP58,NUP35,AAAS,NUP42,NUP93,RAN,NDC1,NUP155,SEH1L
R-HSA-936440	Negative regulators of RIG-I/MDA5 signaling	0.0558619957341588	-2.88487099167477	36	35	0.00387425282266991	9034	10285	7311,100847079,7323,64135,54476,7322,9636,84282,7706,7314,7318,29110,9246,9474,5300,9641,7316,3093,54941,100500827,8887,7128,83737,57506,51191,6233,79671,5094,23586,7321,84166,3661,9140,7187,1540	UBA52,MIR5193,UBE2D3,IFIH1,RNF216,UBE2D2,ISG15,RNF135,TRIM25,UBB,UBA7,TBK1,UBE2L6,ATG5,PIN1,IKBKE,UBC,UBE2K,RNF125,MIR3614,TAX1BP1,TNFAIP3,ITCH,MAVS,HERC5,RPS27A,NLRX1,PCBP2,RIGI,UBE2D1,NLRC5,IRF3,ATG12,TRAF3,CYLD
R-HSA-1250196	SHC1 events in ERBB2 signaling	0.057479718963628	-2.85632310707297	22	22	0.00243524463139252	9034	10285	5782,2064,145957,10718,3265,3845,6464,3084,4893,2885,5581,2069,2066,5580,9542,6654,5578,685,2065,1956,1950,1839	PTPN12,ERBB2,NRG4,NRG3,HRAS,KRAS,SHC1,NRG1,NRAS,GRB2,PRKCE,EREG,ERBB4,PRKCD,NRG2,SOS1,PRKCA,BTC,ERBB3,EGFR,EGF,HBEGF
R-HSA-389357	CD28 dependent PI3K/Akt signaling	0.057479718963628	-2.85632310707297	22	22	0.00243524463139252	9034	10285	941,2475,8503,5296,3932,1326,253260,9020,117145,207,940,5295,10000,5170,55615,5290,64223,79109,57761,2534,942,208	CD80,MTOR,PIK3R3,PIK3R2,LCK,MAP3K8,RICTOR,MAP3K14,THEM4,AKT1,CD28,PIK3R1,AKT3,PDPK1,PRR5,PIK3CA,MLST8,MAPKAP1,TRIB3,FYN,CD86,AKT2
R-HSA-389513	CTLA4 inhibitory signaling	0.057479718963628	-2.85632310707297	22	22	0.00243524463139252	9034	10285	6714,207,4067,5519,5525,5527,3932,941,5526,5528,942,208,5516,5518,2534,7525,5529,5515,10000,1493,5170,5781	SRC,AKT1,LYN,PPP2R1B,PPP2R5A,PPP2R5C,LCK,CD80,PPP2R5B,PPP2R5D,CD86,AKT2,PPP2CB,PPP2R1A,FYN,YES1,PPP2R5E,PPP2CA,AKT3,CTLA4,PDPK1,PTPN11
R-HSA-1368108	BMAL1:CLOCK,NPAS2 activates circadian gene expression	0.0575335320468876	-2.85538733512124	48	46	0.00509187513836617	9034	10285	1407,23054,5465,2908,10891,23373,9611,150094,8553,6095,8841,56938,1628,1408,2033,2155,406,79718,10499,9575,28999,10498,79365,9572,6256,8864,1390,4862,5054,8204,6604,5936,1387,1385,551,85441,100302237,5187,25819,5469,4783,3091,96764,80205,8648,10135	CRY1,NCOA6,PPARA,NR3C1,PPARGC1A,CRTC1,NCOR1,SIK1,BHLHE40,RORA,HDAC3,BMAL2,DBP,CRY2,EP300,F7,BMAL1,TBL1XR1,NCOA2,CLOCK,KLF15,CARM1,BHLHE41,NR1D1,RXRA,PER2,CREM,NPAS2,SERPINE1,NRIP1,SMARCD3,RBM4,CREBBP,CREB1,AVP,HELZ2,MIR1281,PER1,NOCT,MED1,NFIL3,HIF1A,TGS1,CHD9,NCOA1,NAMPT
R-HSA-187706	Signalling to p38 via RIT and RIN	0.0587492616439205	-2.8344766937999	249	227	0.0251272968784592	9034	10285	5245,801,5037,6709,1950,9542,8817,5687,5894,5518,51332,815,5786,3845,5908,3716,8831,284,1843,5695,2252,5604,5623,1439,57731,5696,5536,23198,88,1844,7979,10125,143471,5710,122706,4893,6710,2255,5692,7010,6014,685,5154,10048,283455,6708,3690,3667,115727,5708,53358,9861,2246,2064,5519,3084,5717,5527,100847012,3674,2254,64096,9693,7450,1846,5719,5529,4803,817,2534,5693,8660,8074,27040,5691,2065,5156,54756,6016,8437,3558,5155,818,2066,7414,2244,11221,25759,5720,408,1437,9048,4233,3082,28956,2251,25780,2243,27006,9365,2260,3559,4254,5700,5528,5718,2253,5605,6233,3562,5707,8682,5694,84078,3265,5594,3568,1848,221002,3717,5685,1742,6712,5690,5686,1839,1956,8315,5704,10156,2264,2904,6464,5924,7316,5159,2675,2263,2069,10817,2903,5923,9491,2676,10197,5701,2261,2335,161742,2247,9965,2250,1849,5921,6654,5526,200734,808,7529,145957,84292,5525,5715,5682,80824,4140,1445,7314,5515,8822,2674,2885,5906,5747,3718,5922,4296,9462,1850,2249,399473,3567,4763,1847,5516,5702,5714,816,3560,4747,5979,8452,5698,54518,6714,10213,5713,10256,152559,9978,64926,153090,4902,805,5684,7311,5699,26281,5595,10818,409,2668,10142,2905,6711,8649,4684,673,8826,4914,5711,3815,2906,10718,2248,2266,5706	PHB1,CALM1,PEBP1,SPTAN1,EGF,NRG2,FGF18,PSMA6,RAF1,PPP2R1A,SPTBN5,CAMK2A,PTPRA,KRAS,RAP1B,JAK1,SYNGAP1,ANGPT1,DUSP1,PSMB7,FGF7,MAP2K1,PSPN,CSF2RB,SPTBN4,PSMB8,PPP5C,PSME4,ACTN2,DUSP2,SEM1,RASGRP1,PSMA8,PSMD4,PSMB11,NRAS,SPTB,FGF10,PSMB4,TEK,RIT2,BTC,PDGFA,RANBP9,KSR2,SPTA1,ITGB3,IRS1,RASGRP4,PSMD2,SHC3,PSMD6,FGF1,ERBB2,PPP2R1B,NRG1,PSMD11,PPP2R5C,MIR5004,ITGA2B,FGF9,GFRA4,RAPGEF2,VWF,DUSP4,PSMD13,PPP2R5E,NGF,CAMK2D,FYN,PSMB5,IRS2,FGF23,LAT,PSMB3,ERBB3,PDGFRA,IL17RD,RIT1,RASAL1,IL2,PDGFB,CAMK2G,ERBB4,VCL,FGB,DUSP10,SHC2,PSME1,ARRB1,CSF2,ARTN,MET,HGF,LAMTOR2,FGF6,RASGRP3,FGA,FGF22,KL,FGFR1,IL2RA,KITLG,PSMC1,PPP2R5D,PSMD12,FGF8,MAP2K2,RPS27A,IL3,PSMD1,PEA15,PSMB6,KBTBD7,HRAS,MAPK1,IL5RA,DUSP6,RASGEF1A,JAK2,PSMA4,DLG4,SPTBN2,PSMB2,PSMA5,HBEGF,EGFR,BRAP,PSMC4,RASA4,FGFR4,GRIN2B,SHC1,RASGRF2,UBC,PDGFRB,GFRA2,FGFR2,EREG,FRS3,GRIN2A,RASGRF1,PSMF1,GFRA3,PSME3,PSMC2,FGFR3,FN1,SPRED1,FGF2,FGF19,FGF5,DUSP7,RASA1,SOS1,PPP2R5B,SPRED2,CALM3,YWHAB,NRG4,WDR83,PPP2R5A,PSMD9,PSMA1,DUSP16,MARK3,CSK,UBB,PPP2CA,FGF17,GFRA1,GRB2,RAP1A,PTK2,JAK3,RASA2,MAP3K11,RASAL2,DUSP8,FGF4,SPRED3,IL5,NF1,DUSP5,PPP2CB,PSMC3,PSMD8,CAMK2B,IL2RB,NEFL,RET,CUL3,PSMB9,APBB1IP,SRC,PSMD14,PSMD7,CNKSR1,PAQR3,RBX1,RASAL3,DAB2IP,NRTN,CALM2,PSMA3,UBA52,PSMB10,FGF20,MAPK3,FRS2,ARRB2,GDNF,AKAP9,GRIN2C,SPTBN1,LAMTOR3,NCAM1,BRAF,IQGAP1,NTRK1,PSMD5,KIT,GRIN2D,NRG3,FGF3,FGG,PSMC6
R-HSA-170984	ARMS-mediated activation	0.0587492616439205	-2.8344766937999	249	227	0.0251272968784592	9034	10285	10818,5595,26281,5699,7311,5684,805,4902,153090,64926,152559,9978,5713,10256,5706,2266,2248,10718,2906,3815,5711,4914,8826,4684,673,6711,8649,2668,10142,2905,409,5702,5516,4763,1847,399473,3567,1850,2249,9462,5922,3718,4296,2885,5906,2674,5747,8822,5515,7314,1445,4140,80824,10213,6714,5698,54518,5979,8452,4747,3560,816,5714,9491,10197,2676,5923,2903,2069,10817,2263,2675,7316,5159,5715,5525,5682,84292,145957,7529,200734,808,6654,5526,5921,2250,1849,9965,2247,161742,2335,2261,5701,5686,5690,6712,1742,3717,5685,221002,1848,3568,5594,5924,6464,2904,10156,2264,5704,8315,1839,1956,3559,4254,5700,2260,2243,9365,27006,28956,2251,25780,3082,4233,9048,1437,408,3265,84078,5694,8682,5707,5605,6233,3562,2253,5528,5718,1398,5693,2534,4803,817,5719,5529,7450,9693,1846,3674,100847012,2254,64096,5720,25759,2244,11221,2066,818,7414,5155,3558,8437,54756,5156,5691,8074,27040,2065,8660,5692,2255,6710,122706,4893,143471,5710,10125,7979,1844,23198,88,3084,5527,5717,5519,2064,2246,53358,9861,5708,115727,3667,6708,3690,5154,10048,283455,685,7010,3716,3845,5908,5786,57498,51332,815,5518,5894,8817,9542,5687,1950,6709,5037,801,5245,5536,57731,5696,1439,5623,5604,2252,5695,1843,284,8831	FRS2,MAPK3,FGF20,PSMB10,UBA52,PSMA3,CALM2,NRTN,DAB2IP,RASAL3,PAQR3,RBX1,PSMD7,CNKSR1,PSMC6,FGG,FGF3,NRG3,GRIN2D,KIT,PSMD5,NTRK1,IQGAP1,NCAM1,BRAF,SPTBN1,LAMTOR3,GDNF,AKAP9,GRIN2C,ARRB2,PSMC3,PPP2CB,NF1,DUSP5,SPRED3,IL5,DUSP8,FGF4,RASAL2,RASA2,JAK3,MAP3K11,GRB2,RAP1A,GFRA1,PTK2,FGF17,PPP2CA,UBB,CSK,MARK3,DUSP16,PSMD14,SRC,PSMB9,APBB1IP,RET,CUL3,NEFL,IL2RB,CAMK2B,PSMD8,PSMF1,PSME3,GFRA3,RASGRF1,GRIN2A,EREG,FRS3,FGFR2,GFRA2,UBC,PDGFRB,PSMD9,PPP2R5A,PSMA1,WDR83,NRG4,YWHAB,SPRED2,CALM3,SOS1,PPP2R5B,RASA1,FGF5,DUSP7,FGF19,FGF2,SPRED1,FN1,FGFR3,PSMC2,PSMA5,PSMB2,SPTBN2,DLG4,JAK2,PSMA4,RASGEF1A,DUSP6,IL5RA,MAPK1,RASGRF2,SHC1,GRIN2B,RASA4,FGFR4,PSMC4,BRAP,HBEGF,EGFR,IL2RA,KITLG,PSMC1,FGFR1,FGA,KL,FGF22,LAMTOR2,FGF6,RASGRP3,HGF,MET,ARTN,CSF2,ARRB1,HRAS,KBTBD7,PSMB6,PEA15,PSMD1,MAP2K2,RPS27A,IL3,FGF8,PPP2R5D,PSMD12,CRK,PSMB5,FYN,NGF,CAMK2D,PSMD13,PPP2R5E,VWF,RAPGEF2,DUSP4,ITGA2B,MIR5004,FGF9,GFRA4,PSME1,SHC2,FGB,DUSP10,ERBB4,CAMK2G,VCL,PDGFB,IL2,RASAL1,IL17RD,PDGFRA,PSMB3,FGF23,LAT,ERBB3,IRS2,PSMB4,FGF10,SPTB,PSMB11,NRAS,PSMA8,PSMD4,RASGRP1,SEM1,DUSP2,PSME4,ACTN2,NRG1,PPP2R5C,PSMD11,PPP2R1B,ERBB2,FGF1,SHC3,PSMD6,PSMD2,RASGRP4,IRS1,SPTA1,ITGB3,PDGFA,RANBP9,KSR2,BTC,TEK,JAK1,KRAS,RAP1B,PTPRA,KIDINS220,SPTBN5,CAMK2A,PPP2R1A,RAF1,FGF18,NRG2,PSMA6,EGF,SPTAN1,PEBP1,CALM1,PHB1,PPP5C,SPTBN4,PSMB8,CSF2RB,PSPN,MAP2K1,FGF7,PSMB7,DUSP1,ANGPT1,SYNGAP1
R-HSA-6798695	Neutrophil degranulation	0.0607019702548524	-2.80177912254968	487	439	0.0485941996900598	9034	10285	124583,64333,567,5806,1075,201294,7097,7130,1794,1828,8673,6037,5908,683,3320,4311,11314,23317,2990,11031,29099,10312,10321,5695,79792,5879,8655,10890,1991,5864,968,387263,6283,25798,326624,5175,54918,55313,5005,4057,671,2760,8876,5878,240,728,3074,10092,51071,28988,4893,6556,8635,353376,847,57020,5269,2219,5717,1265,9545,634,3685,8993,3916,2268,116844,9861,8288,140885,929,102,5719,3043,5768,2821,197,80331,6286,83716,9145,22875,10533,5657,10394,9798,5315,221,1832,2896,51719,210,8836,196527,7414,728358,2444,3163,290,3683,55,4973,1992,226,1938,51552,2171,8514,1675,10487,4718,10120,178,4282,5023,10788,5718,84514,5870,5553,388698,327,10562,1084,1522,51816,6282,23200,6590,79895,23352,4758,1118,4069,2588,57554,5594,4257,84658,2547,25801,80184,54472,5686,8773,9522,5869,121260,5777,5660,5795,6278,978,84766,89777,29108,566,10855,4332,8804,7276,114790,3837,154664,6279,9103,12,8560,10694,10396,5547,5701,5912,2352,383,945,1727,79888,11010,27180,9761,6793,1729,387,10043,5646,3107,2548,58485,1378,2512,5702,387921,3304,23385,6515,427,5329,5223,3312,3136,1088,51646,25840,5580,5328,10097,23218,22931,1143,1604,199675,374395,7305,100847046,64386,820,960,2683,3614,4860,8649,10576,6947,56888,79930,23071,5834,10970,4353,401258,170482,3101,1512,2934,3071,6518,47,302,81619,5337,5273,4680,84418,3608,6709,1669,2519,2207,55276,967,2040,2357,51316,55832,3958,976,22918,4790,258010,8778,9535,3903,10875,3240,203068,1778,5284,535,684,5236,3579,7415,9218,317,2665,23406,10577,51125,5708,6616,411,23593,175,353,8566,2358,222487,1116,3105,353189,2919,30,965,127829,3106,6727,338339,51411,3577,3684,5663,161,64114,2799,5049,25797,23197,388697,718,272,79980,2720,5799,8904,81567,28956,1667,823,8987,4048,5004,2517,5707,963,441864,10326,3310,1915,7226,25852,1511,79169,5611,3615,5787,8907,6036,4318,7077,23526,55860,100049587,11333,1509,3934,80301,5036,1476,6836,11322,966,51143,83858,100616211,23601,1823,3326,5836,51382,391,10450,961,11240,51806,56729,138050,8895,5478,5724,26,1315,2992,5873,1650,5211,3728,6402,932,9588,54509,3687,55754,160364,1508,8621,2215,5265,340061,7133,3689,3848,53917,55004,56954,4033,11001,4317,23191,80142,4831,5906,9725,2950,5788,4125,2495,5317,10213,1520,26578,7520,1432,4126,6317,8972,6280,1471,23412,53831,5713,84329,2204,23250,1535,948,6386,7879,3146,719,57153,3482,3417,8826,150372,6993,23114,9961,2212	CANT1,ARHGAP9,B2M,PTX3,CTSC,UNC13D,TLR2,TNFAIP6,DOCK2,DSG1,VAMP8,RNASE3,RAP1B,BST1,HSP90AA1,MME,CD300A,DNAJC13,GUSB,RAB31,COMMD9,TCIRG1,CRISP3,PSMB7,GSDMD,RAC1,DYNLL1,RAB10,ELANE,RAB3A,CD68,C6orf120,S100A12,BRI3,RAB37,PECAM1,CMTM6,CPPED1,ORM2,LTF,BPI,GM2A,VNN1,RAB5C,ALOX5,C5AR1,HEXB,ARPC5,DERA,DBNL,NRAS,SLC11A1,RNASET2,TICAM2,CAT,VPS35L,SERPINB6,FCN1,PSMD11,CNN2,RAB3D,CEACAM1,ITGAV,PGLYRP1,LAMP1,FGR,LRG1,PSMD6,EPX,SIRPA,CD14,ADAM10,PSMD13,HBB,QSOX1,GPI,AHSG,DNAJC5,S100P,CRISPLD2,SYNGR1,ENPP4,ATG7,PRTN3,PRG3,IST1,PKM,ALDH3B1,DSP,GRN,CAB39,ALAD,GGH,ANO6,VCL,DEFA1B,FRK,HMOX2,ANPEP,ITGAL,ACP3,OLR1,SERPINB1,ALDOA,EEF2,RAB14,FABP5,KCNAB2,CFD,CAP1,NDUFC2,ACTR1B,AGL,MIF,P2RX1,IQGAP2,PSMD12,GHDC,RAB6A,PRG2,FLG2,APEH,OLFM4,CEACAM3,CTSZ,ADA2,S100A11,ATP11B,SLPI,ATP8B4,UBR4,NEU1,CHIT1,LYZ,GALNS,LRRC7,MAPK1,MGST1,ADGRE3,XRCC6,GCA,CEP290,TOLLIP,PSMA5,SNAP23,SCAMP1,RAB5B,SLC15A4,PTPN6,PSAP,PTPRJ,S100A7,CDA,CRACR2A,SERPINB12,PYCARD,AZU1,HPSE,MNDA,CREG1,TTR,STK11IP,KPNB1,ABCA13,S100A8,FCGR2C,SERPINA3,DEGS1,CCT8,ATP8A1,PRCP,PSMC2,RAP2B,FOLR3,ARG1,CD33,CYB5R3,LPCAT1,GLIPR1,SIGLEC9,MLEC,STK10,DIAPH1,RHOA,TOM1,PRSS3,HLA-C,GAA,TRAPPC1,CR1,FTL,PSMC3,NHLRC3,HSPA1B,NCSTN,SLC2A3,ASAH1,PLAUR,PGAM1,HSPA8,HLA-H,CEACAM8,YPEL5,TMT1A,PRKCD,PLAU,ACTR2,NBEAL2,RAB18,CHRNB4,CD55,MCEMP1,TMEM179B,TYROBP,MIR5010,MMP25,CAMP,CD44,B4GALT1,IMPDH1,PNP,LAMTOR3,CCT2,TCN1,KCMF1,DOK3,ERP44,PYGB,CKAP4,MPO,RAB44,CLEC4C,HK3,CTSH,GSN,NCKAP1L,SLC2A5,ACLY,ANXA2,TSPAN14,PLD1,SERPINB10,CEACAM6,CYSTM1,ILF2,SPTAN1,DEFA4,FUCA2,FCER1G,PGM2,CD63,STOM,FPR1,PLAC8,CAND1,LGALS3,ADGRE5,CD93,NFKB1,SVIP,SIGLEC5,GMFG,LAIR1,FGL2,HP,TUBB,DYNC1H1,PIGR,ATP6V0A1,BST2,PGM1,CXCR2,VCP,VAPA,APAF1,GDI2,COTL1,NPC2,GOLGA7,PSMD2,SNAP25,ARSB,HEBP2,AGA,APRT,PDXK,FPR2,ADGRG3,CHI3L1,HLA-A,SLCO4C1,CXCL1,ACAA1,CD58,ARL8A,HLA-B,SRP14,CLEC4D,BIN2,CXCR1,ITGAM,PSEN1,AP2A2,TMBIM1,GNS,PAFAH1B2,QPCT,FAF2,HRNR,C3,AMPD3,DSN1,GLB1,PTPRN2,CPNE1,TXNDC5,LAMTOR2,DEFA1,CAPN1,STBD1,LTA4H,ORM1,FUCA1,PSMD1,CD53,TARM1,SIRPB1,HSPA6,EEF1A1,TRPM2,ARMC8,CTSG,C1orf35,DNAJC3,IMPDH2,PTPRB,AP1M1,RNASE2,MMP9,TIMP2,ARHGAP45,ACTR10,SIGLEC14,PDAP1,CTSD,LCN2,PLEKHO2,PA2G4,CSTB,SURF4,TMC6,CD59,DYNC1LI1,ATAD3B,MIR4709,CLEC5A,DSC1,HSP90AB1,PYGL,ATP6V1D,RHOG,PPIE,CD47,PADI2,CALML5,RETN,HGSNAT,CPNE3,PPIA,PTAFR,AOC1,COPB1,GYG1,RAB27A,DDOST,PFKL,JUP,SELL,MS4A3,PRDX6,RHOF,ITGAX,TMEM30A,CLEC12A,CTSB,CDK13,FCGR3B,SERPINA1,STING1,TNFRSF1B,ITGB2,KRT1,RAB24,LAMTOR1,NIT2,IRAG2,SLC27A2,MMP8,CYFIP1,PTGES2,NME2,RAP1A,TMEM63A,GSTP1,PTPRC,MAN2B1,FTH1,PKP1,PSMD14,CTSS,OSTF1,XRCC5,MAPK14,MANBA,SERPINB3,MGAM,S100A9,CST3,COMMD3,GPR84,PSMD7,HVCN1,FCAR,ATP11A,CYBA,CD36,SDCBP,RAB7A,HMGB1,C3AR1,SLC44A2,IGF2R,IDH1,IQGAP1,NFAM1,DYNLT1,NFASC,MVP,FCGR2A
R-HSA-5576891	Cardiac conduction	0.0616923001515534	-2.78559615080884	142	131	0.0145007748505645	9034	10285	3753,29098,6717,444,10768,482,3767,6332,6546,3709,3770,1482,4878,775,2281,808,6547,6588,204851,5350,10345,4881,6327,2256,50801,100126325,3776,3751,30818,6326,2257,3777,781,10089,3775,10060,30820,4842,28996,6330,6263,30819,9992,55799,3759,483,786,55800,6910,477,3710,3708,801,6786,480,84876,491,6336,23704,11280,476,815,27092,59285,8645,6335,478,6261,56659,10369,488,6262,10142,3761,83795,59283,60598,8850,486,93589,89822,779,3768,6323,25937,5566,4880,9254,56660,2626,783,10699,489,487,6334,53826,6543,776,5348,53828,59284,805,27091,6328,7220,1760,100616453,3757,80228,80333,54207,3784,816,493,2259,3752,9424,784,818,6329,4882,5349,10008,785,817,490,481,10368,6331,51305,338567	KCNE1,RANGRF,SRI,ASPH,AHCYL1,ATP1B2,KCNJ11,SCN7A,SLC8A1,ITPR2,KCNJ14,NKX2-5,NPPA,CACNA1C,FKBP1B,CALM3,SLC8A3,SLN,HIPK1,PLN,TRDN,NPR1,SCN2B,FGF11,KCNK4,MIR935,KCNK2,KCND2,KCNIP3,SCN2A,FGF12,KCNK3,CACNA2D1,KCNK7,KCNK1,ABCC9,KCNIP1,NOS1,HIPK2,SCN4B,RYR3,KCNIP2,KCNE2,CACNA2D3,KCNJ2,ATP1B3,CACNG1,SCN3B,TBX5,ATP1A2,ITPR3,ITPR1,CALM1,STIM1,ATP1A4,ORAI1,ATP2B2,SCN10A,KCNE4,SCN11A,ATP1A1,CAMK2A,CACNG4,CACNG6,KCNK5,SCN9A,ATP1A3,RYR1,KCNK13,CACNG2,ATP2A2,RYR2,AKAP9,KCNJ4,KCNK16,CACNG8,KCNK15,KAT2B,FXYD2,CACNA2D4,KCNK17,CACNA1S,KCNJ12,SCN1A,WWTR1,PRKACA,NPPC,CACNA2D2,KCNK12,GATA4,CACNB2,CORIN,ATP2A3,ATP2A1,SCN8A,FXYD6,SLC8A2,CACNA1D,FXYD1,FXYD4,CACNG7,CALM2,CACNG5,SCN3A,TRPC1,DMPK,MIR4687,KCNH2,ORAI2,KCNIP4,KCNK10,KCNQ1,CAMK2B,ATP2B4,FGF14,KCND3,KCNK6,CACNB3,CAMK2G,SCN4A,NPR2,FXYD3,KCNE3,CACNB4,CAMK2D,ATP2B1,ATP1B1,CACNG3,SCN5A,KCNK9,KCNK18
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	0.0621488609422977	-2.77822278875093	35	34	0.00376355988487934	9034	10285	23279,1977,22916,23511,348995,5903,23165,100101267,23636,10762,57122,4686,55746,9972,23225,79902,53371,9883,8021,79023,7884,4927,129401,9818,7175,4928,55706,9688,10189,11097,8086,10482,81929,9631	NUP160,EIF4E,NCBP2,NUP188,NUP43,RANBP2,NUP205,POM121C,NUP62,NUP50,NUP107,NCBP1,NUP133,NUP153,NUP210,NUP85,NUP54,POM121,NUP214,NUP37,SLBP,NUP88,NUP35,NUP58,TPR,NUP98,NDC1,NUP93,ALYREF,NUP42,AAAS,NXF1,SEH1L,NUP155
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	0.0621488609422977	-2.77822278875093	35	34	0.00376355988487934	9034	10285	4928,7175,129401,9818,91754,81929,9631,10783,11097,8086,55706,9688,79023,983,9883,8021,4927,55746,57122,9133,53371,79902,9972,23225,348995,23511,891,23279,140609,10762,23636,23165,100101267,5903	NUP98,TPR,NUP35,NUP58,NEK9,SEH1L,NUP155,NEK6,NUP42,AAAS,NDC1,NUP93,NUP37,CDK1,POM121,NUP214,NUP88,NUP133,NUP107,CCNB2,NUP54,NUP85,NUP153,NUP210,NUP43,NUP188,CCNB1,NUP160,NEK7,NUP50,NUP62,NUP205,POM121C,RANBP2
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	0.062916586527496	-2.76594545325709	322	292	0.0323223378348461	9034	10285	6352,51554,9288,2149,6288,4852,79948,3274,2488,54886,4158,6915,3363,11255,3269,2921,29933,643,6869,187,3357,553,1233,1812,3361,3061,624,3350,1880,6374,2832,5697,3814,5660,5739,57007,84109,23620,146,57105,10911,5196,2796,5368,4987,94233,5540,5724,151,6373,170589,6019,5995,1132,6368,3972,59350,6346,2852,1241,4159,623,84539,151306,9294,64748,7253,1815,5032,1907,887,56477,57486,4923,6846,84634,5020,1234,1816,23566,6372,2834,2587,51052,59340,1129,134,221391,338442,338557,5031,2853,4157,3973,6010,185,1269,1133,729230,8811,10803,2867,4295,53637,6750,1909,9287,2841,7200,8484,1235,7252,3576,1131,4829,10663,4161,163404,1814,1236,135,4922,152,53829,5029,1325,57121,10886,2492,58191,10022,4886,5539,5737,140,10850,1910,351,3640,1232,1813,2831,5028,3062,150,5179,4988,5367,3362,9034,6376,183,1128,51738,9890,1889,134864,885,2922,719,6375,10161,1908,2147,6360,2150,1268,2829,319100,136,117579,10316,147,3356,2357,6753,2847,51289,2861,4160,6364,5734,3827,3355,2826,7201,1902,10563,8698,2532,6751,9283,4889,2863,122042,128674,148,3792,257313,339403,4985,2864,3579,2151,165140,5731,594857,83551,552,1524,611,2797,4986,6863,8477,886,2837,728,10887,5729,3352,9934,6357,6754,6363,5733,727,256933,387129,8111,1906,9290,2358,5173,1230,10874,3351,2865,4544,3060,155,9038,2919,3360,129521,23596,1237,154,27202,60675,2920,6755,1081,64805,50865,3577,5732,10692,551,5021,6370,3354,2798,64106,7852,11251,1903,4887,5443,56923,6387,6366,718,122876,2859,6752,1901,3627,6870,6865,301,51083,9718,153,2862,2693,27199,56670,6866,347148,4543,2359	CCL5,ACKR4,TAAR3P,F2R,SAA1,NPY,PLPPR3,HRH2,FSHB,PLPPR1,MC2R,TBXA2R,HTR7,HRH3,HRH1,CXCL3,GPR132,CXCR5,TACR1,APLNR,HTR2B,AVPR1B,CCR4,DRD1,HTR5A,HCRTR1,BDKRB2,HTR1A,GPR183,CXCL5,NPBWR2,PYY,KISS1,PSAP,PTGIR,ACKR3,QRFPR,NTSR2,ADRA1D,CYSLTR2,UTS2,PF4,GNRH1,PNOC,OPRL1,OPN4,NPY4R,PTAFR,ADRA2B,CXCL11,GPHA2,RLN2,RGR,CHRM4,CCL23,LHB,RXFP1,CCL1,GPER1,LTB4R,MC3R,BDKRB1,MCHR2,GPBAR1,S1PR2,PLPPR2,TSHR,DRD4,P2RY11,EDN2,CCKBR,CCL28,NLN,NTSR1,XCL2,KISS1R,OXT,CCR5,DRD5,LPAR3,CXCL6,PRLHR,GALR1,PRLH,HRH4,CHRM2,ADORA1,OPN5,HCAR2,FFAR4,P2RY6,GPR31,MC1R,LHCGR,RHO,AGTR1,CNR2,CHRM5,CCR2,GALR2,CCR9,FFAR2,MLN,S1PR5,SST,EDNRA,TAAR2,GPR18,TRH,GALR3,CCR6,TSHB,CXCL8,CHRM3,NMBR,CXCR6,MC5R,PLPPR5,DRD3,CCR7,ADORA2A,NTS,ADRA2C,P2RY13,P2RY2,CORT,LPAR5,NPFFR2,FSHR,CXCL16,INSL5,NPY1R,PPY,PTGFR,ADORA3,CCL27,EDNRB,APP,INSL3,CCR3,DRD2,NPBWR1,P2RY1,HCRTR2,ADRA2A,PENK,OPRM1,PMCH,HTR6,CCRL2,CX3CL1,AGT,CHRM1,GHRL,PLPPR4,ECE1,TAAR1,CCK,GRP,C3AR1,XCL1,LPAR6,EDN3,F2,CCL16,F2RL1,CNR1,XCR1,TAAR6,ADORA2B,RLN3,NMUR1,ADRA1B,HTR2A,FPR1,SSTR3,MCHR1,RXFP3,GPR37,MC4R,CCL20,PTGER4,KNG1,HTR1F,CCR10,TRHR,LPAR1,CXCL13,S1PR4,ACKR1,SSTR1,GPR37L1,NPY5R,GPR39,RXFP2,PROKR2,ADRA1A,KEL,UTS2B,RXFP4,OPRD1,FFAR1,CXCR2,F2RL2,OXER1,PTGER1,NPS,TAAR8,AVPR1A,CX3CR1,OPN1SW,GNRH2,OPRK1,TAC1,GPR65,CCKAR,UTS2R,C5AR1,PROKR1,PTGDR,HTR1D,P2RY14,CCL13,SSTR4,CCL19,PTGER3,C5,NPB,NPSR1,GPR68,EDN1,GPR55,FPR2,PDYN,CCR1,NMU,HTR1B,FFAR3,MTNR1B,HCRT,ADRB3,TAAR5,CXCL1,HTR4,NMS,OPN3,CCR8,ADRB2,C5AR2,PROK2,CXCL2,SSTR5,CGA,P2RY12,HEBP1,CXCR1,PTGER2,RRH,AVP,OXTR,CCL25,HTR1E,GNRHR,NPFFR1,CXCR4,PTGDR2,S1PR3,NPY2R,POMC,NMUR2,CXCL12,CCL21,C3,GPHB5,GPR35,SSTR2,S1PR1,CXCL10,TACR3,TACR2,ANXA1,GAL,ECE2,ADRB1,MLNR,GHSR,OXGR1,SUCNR1,TAC3,QRFP,MTNR1A,FPR3
R-HSA-556833	Metabolism of lipids and lipoproteins	0.0651512105035999	-2.7310443953291	813	728	0.0805844587115342	9034	10285	5501,51170,23446,29116,85441,283748,80142,80205,9415,2,1717,213,129642,5538,340654,26291,149998,9524,8394,8760,337,19,2053,285362,1584,32,114971,6713,7436,79071,948,29923,122970,23179,341,57491,51205,1109,9412,79644,55911,57104,10715,57153,64180,27306,26279,3417,51141,23590,90390,57834,2629,4899,100302237,28234,163,10728,5288,22949,1490,1622,5901,3284,6579,5007,54600,114879,51573,64600,1387,2820,50487,114876,83401,4056,27242,8877,5346,8895,284161,57605,10908,892,51599,340485,29095,2170,5294,63874,6715,11283,646480,5289,26119,123,57761,2534,6554,10654,30,201164,336,5338,55500,283927,80821,96764,5290,1149,128486,9572,114880,3636,5297,123099,10948,9362,1081,241,8904,2720,5321,5244,8540,9575,84803,22925,54797,7069,57552,10478,5443,51171,55349,3930,9217,2181,23389,5467,1384,64419,9107,376497,9453,3248,5728,200879,2581,1376,345,47,6256,1580,643418,3631,134429,6604,622,166929,9388,1757,23417,10423,7296,392636,3992,635,5445,411,5568,81537,873,10577,116519,23600,51128,1645,2167,2687,8867,151056,54898,54675,56895,1545,29801,6646,22908,1581,7357,84699,150379,253017,501,123745,338,35,57107,6296,9632,26230,83850,196,5296,9477,10455,80306,9600,3155,113612,1666,64834,55825,5867,25865,200576,81693,5565,125981,9926,112812,51129,1208,6916,8647,2230,114883,7004,1586,6770,166785,2222,4758,27063,91012,5291,114881,63924,126282,4594,23533,23305,346606,137964,80270,788,6307,1543,64174,79411,39,55750,23761,10858,6610,56910,5563,5046,31,4547,9871,8443,3030,2180,51586,79777,116255,8611,11343,10802,1119,5320,64801,8396,151742,100527964,9517,51228,5408,1593,9969,26031,57017,33,54477,1071,55304,50486,1457,55512,3292,1103,9663,55224,56848,1213,590,79143,7368,9443,8871,1800,10025,1374,2171,8898,2531,388121,27124,8644,344967,3295,23396,375,6718,5742,142910,643414,55289,4597,29079,5096,284486,9611,54947,6822,8310,9442,646486,91227,4864,51099,2274,56261,1558,55331,5499,64788,242,344,340075,1595,5500,5743,51003,9200,3074,1559,219541,84246,4802,240,2879,4363,9110,84274,79718,23491,4520,3293,23760,56994,29841,117145,3949,81616,10449,405,27349,51703,9619,5125,1573,55908,11001,5287,10005,51302,5833,7108,247,30814,162466,8435,55301,10062,1455,51365,9791,5740,2876,2224,80724,23683,8879,10229,114882,79993,112950,255738,2033,1175,7005,27132,79887,5360,10558,5130,3290,183,64781,255189,55697,11332,9885,231,80772,1718,5406,119548,4800,2101,6609,64850,80221,80765,8529,81490,54677,9489,9915,10427,65985,339221,100616211,114884,6342,11145,335,253558,5319,9440,37,1544,6319,224,8821,10599,6716,59338,1173,7003,8605,147323,51004,2712,23171,57678,171546,51422,1588,2169,80230,641372,8202,10484,79152,57704,133121,246,38,3991,8513,6720,161,79611,10413,80736,3635,4862,9971,83394,9896,11000,79966,570,3157,8463,27329,93492,3033,10390,1962,401494,9023,2168,949,25937,84188,204962,51478,1589,8398,201562,5567,127281,4048,55300,154141,51495,3294,7376,57110,284541,338328,5337,57733,3032,5469,84320,5305,23259,10498,55326,27235,5298,9536,2583,122618,153642,5322,211,8714,222,23309,100137049,2232,22901,9420,81544,51805,400569,8309,80168,79153,1646,8706,9108,253782,30849,5446,84879,51179,5649,5468,60481,3422,8841,9218,23205,165679,22876,8648,8612,58488,56898,1040,2194,1583,10226,239,5295,34,10087,248,427,43,9439,204219,406,3156,146850,6309,5034,4706,56624,126969,5465,5566,23054,5587,390916,50640,84693,10809,2819,64900,9261,6721,55090,150763,64241,3990,5293,26027,4018,6667,25942,1585,8720,3638,29881,142827,65977,10825,197322,79603,10162,126410,5660,56894,3837,8560,3283,5264,5019,130367,3972,29956,8613,5045,10499,84869,5868,79888,1582,1024,11010,10891,8395,319,1056,79626,55361,1211,134526,22937,55856,117245,5286,3988,348,51763,2877,5783,221,4801,57664,84649,7923,1557,8800,23175,5444,79837,2678,4023,6576,1579,133522,51552,5095,55711,4199,91452,649,9441,441282,6095,2173,6785,9612,23344,51144,94101,23646,26063,59339,5407,83930,26061,160,80339,79642,81579,2172,51,345275,8029,8503,1600,29958,22874,145482,10001,23097,64240,84725,8897,1632,3291,3069,6555,1459,2760,25816,377,57488,857,10965,10400,259230,4598,81857,55627,54511,9967	PPP1CC,HSD17B11,SLC44A1,MYLIP,HELZ2,PLA2G4D,PTGES2,CHD9,FADS2,A2M,DHCR7,ALB,MBOAT2,PPT1,LIPM,FGF21,LIPI,TECR,PIP5K1A,CDS2,APOA4,ABCA1,EPHX2,SUMF1,CYP11B1,ACACB,PTPMT1,SQLE,VLDLR,ELOVL6,CD36,HILPDA,ACOT4,RGL1,APOC1,AHRR,ACP6,AKR1C4,MED21,SRD5A3,APOBR,PNPLA2,CERS1,SLC44A2,DPEP3,HPGDS,PLA2G2D,IDH1,INSIG2,PDSS1,MED30,CYP4F11,GBA1,NRF1,MIR1281,SLCO1B3,AP2B1,PTGES3,PIK3C2G,PTGR1,CCN2,DBI,RAN,HSD3B2,SLCO1A2,OSBP,UGT1A9,OSBPL5,GDE1,PLA2G2F,CREBBP,GPD2,PLA2G3,OSBPL1A,ELOVL3,LTC4S,TNFRSF21,SPHK1,PLIN1,CPNE3,GDPD1,PITPNM2,PNPLA6,CCNC,LSR,ACER2,ORMDL2,FABP3,PIK3CG,ABHD4,SRD5A1,CYP4F8,FABP9,PIK3C3,LDLRAP1,PLIN2,TRIB3,FYN,SLC10A1,PMVK,ACAA1,PLD6,APOA2,PLD2,ETNK1,NUDT7,DDHD1,TGS1,PIK3CA,CIDEA,FITM2,NR1D1,OSBPL6,INPPL1,PI4KA,DEGS2,STARD3,CPNE6,CGA,ALOX5AP,CPNE1,GLB1,PLA2G4A,ABCB4,AGPS,CLOCK,GPAT3,PLA2R1,MED18,THRSP,NCEH1,SLC25A17,POMC,HSD17B14,CHDH,LBR,VAPB,ACSL3,MED13L,PPARD,CRAT,MTMR14,MTMR6,SLC27A1,GGPS1,HPGD,PTEN,LIPH,GALC,CPT2,APOC3,ACLY,RXRA,CYP4B1,LIPN,INPP4A,STARD4,SMARCD3,BDH1,SGMS2,LIPG,SARDH,MLYCD,CDIPT,TXNRD1,AGMO,FADS1,BHMT,PON2,ARSB,PRKACG,SGPP1,CBR1,NPC2,APOA5,AMACR,SAR1B,AKR1C1,FABP4,GGT5,SYNJ1,PLB1,ELOVL2,CRLS1,AGPAT4,CYP1B1,ZDHHC8,SOAT1,SACM1L,CYP7A1,UGCG,CREB3L3,PNPLA5,TECRL,ALDH7A1,PLA2G4E,APOB,ACADS,PDSS2,ACSM3,SEC24C,TIAM2,ESYT3,AHR,PIK3R2,MED20,ECI2,MED28,PITPNM1,HMGCL,CYP2U1,DECR1,ELOVL1,PECR,RAB4A,PRKD2,PIKFYVE,AMN,PRKAB2,ACER1,LPGAT1,FDX2,ANGPTL4,CLPS,TBXAS1,ABCB11,FDX1,OSBPL9,TEAD4,CYP17A1,STAR,MMAA,FDFT1,NEU1,ANKRD1,CERS5,PIK3CB,OSBPL7,CIDEC,TNFAIP8L1,MMUT,PIK3R5,ACSL6,MOGAT3,GPAT4,HSD3B7,SLC25A20,MSMO1,CYP1A1,DPEP2,GLB1L,ACAT2,AGK,PISD,CYP46A1,SMPD2,STARD7,PRKAA2,PCSK6,ACACA,MTTP,SEC24D,GNPAT,HADHA,ACSL1,MED15,ACBD4,MOGAT1,PLPP1,MGLL,SEC24A,CHKA,PLA2G2A,ARV1,PIP4K2B,PPM1L,LHX4-AS1,SPTLC2,GLTP,PNLIPRP2,CYP27A1,MED13,OSBPL3,COQ9,ACADL,PLEKHA5,CETP,SPTLC3,G0S2,CSNK2A1,SMPD3,HSD17B1,CHAT,LPIN2,ETNK2,SPHK2,CLTC,BCHE,MBOAT7,UGT8,MED7,SYNJ2,DPEP1,MED16,CPT1A,FABP5,MTMR2,KDSR,TNFAIP8L3,INPP5J,AKR1C3,LOC344967,HSD17B4,PIP5K1C,ARF1,AKR1D1,PTGS1,LIPJ,LIPK,ACOXL,MVD,MED4,PCCB,THEM5,NCOR1,LPCAT2,SULT2A1,ACOX3,MED27,FABP12,GGTLC2,NPC1,ABHD5,FHL2,GPCPD1,CYP2C8,ACER3,PPP1CA,LMF1,ALOX12B,APOC2,ARSI,CYP51A1,PPP1CB,PTGS2,MED31,HACD1,HEXB,CYP2C9,MED19,MED10,NFYC,ALOX5,GPX4,ABCC1,MTMR4,COQ5,TBL1XR1,CES3,MTF1,HSD17B3,PITPNB,CHPT1,GRHL1,THEM4,LDLR,ACSBG2,ACAA2,ARNT,MCAT,ACSL5,ABCG1,PCSK5,CYP2J2,ANGPTL8,SLC27A2,PIK3C2B,ACOT8,CYP39A1,PCYT2,TM7SF2,ALOX15B,PLA2G2E,PHOSPHO1,SOAT2,OLAH,NR1H3,CSNK1G2,PLA1A,PTDSS1,PTGIS,GPX1,FDPS,ACAD10,PRKD3,SGPL1,COQ7,OSBPL8,ELOVL7,MED8,PCSK9,EP300,AP2S1,TEAD3,CPNE7,PLBD1,PLTP,SPTLC1,PCYT1A,HSD11B1,AGT,CERK,PLA2G4F,VAC14,ACOT7,OSBPL2,AKR1B1,CPTP,DHCR24,PNLIP,PNLIPRP3,NFYA,ESRRA,SMPD1,ETNPPL,ACSF2,STARD5,CYP4F2,PTDSS2,CROT,PGS1,ARNT2,SEC24B,AACS,ENPP7,MIR4709,OSBPL10,SCP2,PLAAT3,APOA1,LCLAT1,PLA2G1B,MED17,ACADVL,CYP1A2,SCD,ALDH3A2,INPP4B,SLCO1B1,SRD5A2,PLEKHA1,AP2M1,TEAD1,PLA2G4C,STARD6,COQ6,GK2,GPD1L,GPAM,SPTSSA,PRKAG2,CYP19A1,FABP2,RUFY1,ACOT6,NCOA3,SEC23A,FA2H,GBA2,ENPP6,ALOX15,ACAT1,LIPE,LIPF,SREBF1,AP2A2,ACSS3,YAP1,SLC44A4,INPP5D,NPAS2,NR1H4,PITPNM3,FIG4,SLC27A3,SCD5,BAAT,HMGCS1,TEAD2,ANGPTL3,TPTE2,HADH,CEPT1,EHHADH,HACD4,CH25H,FABP1,SCARB1,WWTR1,FAR1,SLC44A5,HSD17B7,CYP21A2,PLA2G6,HACD2,PRKACB,PRXL2B,LTA4H,PI4K2B,MBOAT1,HACD3,HSD17B2,NR1H2,PLAAT1,CYP4A22,GPIHBP1,PLD1,GBA3,HADHB,MED1,ACBD6,PIP4K2A,DDHD2,CARM1,AGPAT5,COQ2,PI4KB,PTGES,B4GALNT1,PLD4,ARSK,PLA2G5,ALAS1,ABCC3,ALDH3B2,SIN3B,PLA2G4B,FDXR,ARSG,CYP7B1,GDPD5,COQ3,MED11,ACOX2,MOGAT2,GDPD3,AKR1C2,B3GALNT1,MTMR7,CERS6,PIK3R4,PON3,MFSD2A,HAO2,RELN,PPARG,ELOVL5,IDI1,HDAC3,VAPA,ACSBG1,SPTSSB,INPP5F,NCOA1,PLPP2,PCTP,BDH2,CDS1,FASN,CYP11A1,PLIN3,ALOX12,PIK3R1,ACADM,CERT1,ALPI,ASAH1,ACHE,MED23,CERS3,BMAL1,HMGCR,PIK3R6,SC5D,P4HB,NDUFAB1,ASAH2,SLC44A3,PPARA,PRKACA,NCOA6,PRKD1,NUDT19,PNPLA8,MCEE,STARD10,GPD1,LPIN3,MAPKAPK2,SREBF2,MED9,GPAT2,ABCG8,LIPC,PIK3CD,ACOT11,LPA,SP1,SIN3A,CYP11B2,MBTPS1,INSIG1,NPC1L1,ACSM6,PLEKHA3,NEU3,ACSF3,CERS4,LPCAT3,CYP4F22,PSAP,AGPAT3,KPNB1,DEGS1,HSD3B1,PHYH,OXCT1,SGPP2,LHB,CERS2,PLPP3,FURIN,NCOA2,CBR4,RAB5A,LPCAT1,CYP8B1,CDK8,GLIPR1,PPARGC1A,PIP5K1B,APOF,CEL,TNFAIP8L2,PI4K2A,CLTA,ACOT12,SCAP,ACOT13,PLAAT5,PIK3C2A,LIPA,APOE,INPP5K,GPX2,PTPN13,ALDH3B1,NFYB,PLEKHA4,DGAT2,HSD17B8,CYP2C19,PEX11A,LPIN1,PON1,PIP4K2C,GGT1,LPL,SLC25A1,CYP4A11,PPARGC1B,RAB14,PCCA,FAR2,ME1,ACBD5,BMP1,MED26,AKR1B15,RORA,FABP7,ELOVL4,NCOR2,ESYT1,HSD17B12,ORMDL1,PLD3,DECR2,PLEKHA2,PNLIPRP1,STARD3NL,HACL1,AP2A1,PNPLA3,ARSJ,PLA2G12A,FABP6,ACOX1,HSD17B13,CUBN,PIK3R3,DAB1,DMGDH,PLEKHA6,PTGR2,MED6,CDK19,ABCG5,PLEKHA8,MTMR3,ECI1,HSD11B2,HDLBP,SLC10A2,CSNK2A2,GM2A,TNFAIP8,ARF3,ESYT2,CAV1,ACOT2,PEMT,SGMS1,MVK,MED25,SMPD4,HMGCLL1,THRAP3
R-HSA-163685	Integration of energy metabolism	0.0651839854726737	-2.73054146180421	111	103	0.0114013725924286	9034	10285	2791,2771,2740,776,150,5576,2778,9495,2783,32,9370,5575,5577,79602,5528,3745,196883,3747,8826,23236,5565,6794,5567,6812,9630,2793,777,2788,9254,783,5566,6833,2642,2194,2769,5515,5331,51764,5906,51422,4082,5516,3630,10411,94235,152,6844,51094,2784,784,1131,111,26251,402,5578,112,6514,114,5563,2864,291,2776,31,10768,5573,3709,3790,2787,3767,115,5568,23568,6888,6616,6861,775,2767,2641,2786,5519,2790,2770,59345,773,3708,10681,51085,47,108,5518,11069,5313,2782,113,55970,107,109,6513,54331,7086,5330,3710,2792	GNG11,GNAI2,GLP1R,CACNA1D,ADRA2A,PRKAR2A,GNAS,AKAP5,GNB2,ACACB,ADIPOQ,PRKAR1B,PRKAR2B,ADIPOR2,PPP2R5D,KCNB1,ADCY4,KCNC2,IQGAP1,PLCB1,PRKAB2,STK11,PRKACB,STXBP1,GNA14,GNGT2,CACNA1E,GNG7,CACNA2D2,CACNB2,PRKACA,ABCC8,GCGR,FASN,GNA15,PPP2CA,PLCB3,GNG13,RAP1A,PRKAG2,MARCKS,PPP2CB,INS,RAPGEF3,GNG8,ADRA2C,VAMP2,ADIPOR1,GNB3,CACNB3,CHRM3,ADCY5,KCNG2,ARL2,PRKCA,ADCY6,SLC2A2,ADCY8,PRKAA2,FFAR1,SLC25A4,GNAQ,ACACA,AHCYL1,PRKAR1A,ITPR2,KCNS3,GNG5,KCNJ11,ADCY9,PRKACG,ARL2BP,TALDO1,SNAP25,SYT5,CACNA1C,GNA11,GCG,GNG4,PPP2R1B,GNG10,GNAI1,GNB4,CACNA1A,ITPR1,GNB5,MLXIPL,ACLY,ADCY2,PPP2R1A,RAPGEF4,PKLR,GNB1,ADCY7,GNG12,ADCY1,ADCY3,SLC2A1,GNG2,TKT,PLCB2,ITPR3,GNGT1
R-HSA-3700989	Transcriptional Regulation by TP53	0.0651925397613021	-2.73041023743502	367	332	0.0367500553464689	9034	10285	4683,10919,85456,10848,5515,3486,7314,3622,8621,1340,9125,55004,9212,5516,1108,6882,1616,5562,9150,6829,11073,64223,2963,7532,2353,581,9656,27161,3066,8797,1432,83860,891,79370,4193,133383,387893,1350,5810,1026,3065,4331,138474,5439,4343,6875,10670,5876,639,55367,3276,2033,116028,6009,6341,7311,56950,5600,2810,4194,79109,835,5458,83695,1022,6794,8649,5111,834,5565,51241,7469,8445,285521,57472,55571,995,1337,4292,5430,54815,7486,100506888,29883,25946,5052,5170,7534,94241,5300,27113,900,1107,10000,2071,100302237,9099,57690,8626,4697,6874,2965,55835,5884,26523,4869,6924,25904,890,28996,100302168,53615,1387,8900,580,23774,2068,27327,54205,5564,6884,5457,9540,7001,162699,5883,6923,7316,5440,25824,64121,10524,58484,51755,7936,5563,7531,7156,6883,2177,8396,27166,6827,3364,545,7533,1647,6881,2962,7862,902,8812,83990,204851,5371,50484,7529,6749,253260,6921,22974,5608,10111,6873,2968,6119,28984,51497,5433,208,116228,665,2821,843,55215,472,27244,26013,1020,51422,57459,641,2475,10971,144455,389541,7832,83667,1327,4849,5892,8795,1027,7027,11200,672,5984,80196,1345,9156,1457,207,27154,2877,144715,1820,7159,5431,8738,4848,124446,6877,10650,80010,64769,2936,1263,898,100126332,1643,404672,6880,5983,192670,51230,23019,57103,5366,28956,79837,9377,6233,143686,112858,100302242,6118,1869,5434,10397,3725,5441,7874,1874,5395,5933,55615,57060,1351,6917,332,7249,117584,29117,9134,355,6790,84126,9219,23368,9337,8793,9167,1111,63970,983,11198,5982,133746,53632,5518,5728,2967,10769,4436,147923,2744,8178,23112,84987,1353,54541,10498,6879,10542,10419,1386,5305,5432,1459,7295,51224,192669,9891,7157,2176,905,4850,7296,839,10128,1329,58528,1029,55240,5325,8851,1763,1017,7029,5571,317,5934,84883,64065,7994,7248,91875,5985,54971,27165,5519,6117,8794,904,5527,5928,6446,604,7161,4361,246175,57521	NBN,EHMT2,TNKS1BP1,PPP1R13L,PPP2CA,IGFBP3,UBB,ING2,CDK13,COX6B1,CNOT9,LAMTOR1,AURKB,PPP2CB,CHD4,TAF11,DAXX,PRKAA1,CTDP1,SUPT5H,TOPBP1,MLST8,GTF2F2,YWHAG,FOS,BAX,MDC1,AGO2,HDAC2,TNFRSF10A,MAPK14,TAF3,CCNB1,BCL2L14,MDM2,SETD9,KMT5A,COX7C,RAD1,CDKN1A,HDAC1,MNAT1,TAF1L,POLR2J,MOV10,TAF4B,RRAGA,RABGGTB,PRDM1,PIDD1,PRMT1,EP300,RMI2,RHEB,SCO1,UBA52,SMYD2,MAPK11,SFN,MDM4,MAPKAP1,CASP2,POU4F2,RHNO1,CDK7,STK11,LAMTOR3,PCNA,CASP1,PRKAB2,COX16,NELFA,DYRK2,COX18,CNOT6,CNOT11,CDC25C,COX6A1,MLH1,POLR2A,GATAD2A,WRN,ELOA3DP,CNOT7,ZNF385A,PRDX1,PDPK1,YWHAZ,TP53INP1,PIN1,BBC3,CCNG1,CHD3,AKT3,ERCC3,MIR1281,USP2,TNRC6C,TP63,NDUFA4,TAF4,GTF2H1,CENPJ,RAD17,AGO1,NPM1,ELOA,CNOT10,CCNA2,HIPK2,MIR1257,MBD3,CREBBP,CCNA1,BARD1,BRD1,ERCC2,TNRC6A,CYCS,PRKAB1,TAF13,POU4F1,TP53I3,PRDX2,ELOA3P,RAD9A,ELOB,UBC,POLR2K,PRDX5,RRAGC,KAT5,NLRC4,CDK12,NELFE,PRKAA2,YWHAE,TOP3A,TAF12,FANCD2,PIP4K2B,PRELID1,SUPT4H1,HUS1,ATR,YWHAH,GADD45A,TAF10,GTF2F1,BRPF1,CCNH,CCNK,BRIP1,HIPK1,PML,RRM2B,YWHAB,SSRP1,RICTOR,ELOC,TPX2,MAP2K6,RAD50,TAF2,GTF2H4,RPA3,RGCC,NELFCD,POLR2D,AKT2,COX20,BNIP3L,GPI,CASP10,FANCI,ATM,SESN1,L3MBTL1,CDK5,PRKAG2,GATAD2B,BLM,MTOR,YWHAQ,E2F7,LAMTOR4,BTG2,SESN2,COX4I1,CNOT3,RAD51D,TNFRSF10B,CDKN1B,TFDP1,CHEK2,BRCA1,RFC4,RNF34,COX6C,EXO1,CSNK2A1,AKT1,BRPF3,GPX2,RAD9B,ARID3A,TP53BP2,POLR2B,CRADD,CNOT2,TMEM219,TAF5,PRELID3A,RMI1,MEAF6,GSR,PLK3,CCNE1,MIR943,DDB2,GTF2H5,TAF9,RFC3,AGO4,PHF20,CNOT1,TIGAR,PMAIP1,LAMTOR2,PIP4K2C,COX5A,RPS27A,SESN3,TP53RK,MIR1236,RPA2,E2F1,POLR2E,NDRG1,JUN,POLR2L,USP7,E2F4,PMS2,RBL1,PRR5,PCBP4,COX8A,TCEA1,BIRC5,TSC2,RFFL,BRD7,CCNE2,FAS,AURKA,ATRIP,MTA2,PPP1R13B,CNOT8,TNFRSF10D,COX7A2L,CHEK1,TP53AIP1,CDK1,SUPT16H,RFC2,JMY,PRKAG3,PPP2R1A,PTEN,GTF2H3,PLK2,MSH2,ZNF420,GLS,ELL,TNRC6B,COX14,COX11,DDIT4,CARM1,TAF7,LAMTOR5,PRMT5,ATF2,PIP4K2A,POLR2C,CSNK2A2,TXN,ELOA2,AGO3,NUAK1,TP53,FANCC,CCNT2,CNOT4,TXNRD1,CASP6,LRPPRC,COX5B,RRAGD,CDKN2A,STEAP3,PLAGL1,CDK5R1,DNA2,CDK2,TFDP2,PRKAG1,APAF1,RBL2,AIFM2,PERP,KAT6A,TSC1,TTC5,RFC5,BANP,GLS2,PPP2R1B,RPA1,TNFRSF10C,CCNT1,PPP2R5C,RBBP4,SGK1,BCL6,TP73,MRE11,CNOT6L,RPTOR
R-HSA-446203	Asparagine N-linked glycosylation	0.065352979042803	-2.72795225398606	284	258	0.0285587779499668	9034	10285	9117,26984,64689,23243,377,29906,79090,6708,7415,5861,26503,10972,29880,57134,2153,9527,51128,267,51693,55343,79139,378,10299,23256,10282,6710,10610,6483,10020,1778,7844,10342,57731,7991,55014,4245,29925,116150,9695,80267,6484,51035,3703,25839,6400,8655,79796,55291,54732,199857,79748,91869,51332,8702,79087,7841,6811,433,6185,84364,1075,6709,1522,2801,6396,81876,51272,10206,56886,11070,5887,375,6233,2517,338596,4597,9945,10960,79053,9486,85365,83696,2720,64377,51164,381,84447,79694,5700,8703,197258,51014,57171,6184,7903,374,10466,6048,1780,100313843,7369,144245,288,149111,11236,4253,55808,8704,11320,9276,2348,10945,2804,1081,55741,63908,55577,7264,8869,254263,9554,10671,287,8818,1294,57511,10484,56052,10559,6482,64841,2530,22820,10802,8774,90411,1781,9526,4124,1650,10956,10905,10652,256435,1315,83548,29929,22796,51046,821,22845,10113,54344,5373,1783,81849,3972,9871,7316,30815,432,10175,26958,10825,4247,6675,10427,29926,966,5537,51143,84516,91445,11014,55757,4121,2525,27095,26286,55907,6712,55738,11258,5589,122553,2762,4758,7039,11196,6489,10959,1453,22818,84342,54187,9570,7109,79644,2673,6487,8729,140735,84620,91949,8615,6711,10402,11015,7311,4122,11316,1639,5238,124872,2683,372,10195,80896,375056,23423,4249,4351,9334,84920,6480,1604,811,55768,9382,64772,4905,128637,8813,9632,286,10540,3998,1603,4248,23193,58485,89866,3630,8790,9331,11282,22872,79947,9761,27090,5265,7314,25834,140838,5372,8128,2890,51226	SEC22C,SEC22A,GORASP1,ANKRD28,ARF3,ST8SIA5,TRAPPC6A,SPTA1,VCP,RAB1A,SLC17A5,TMED10,ALG5,MAN1C1,F5,GOSR1,SAR1B,AMFR,TRAPPC2L,SLC35C1,DERL1,ARF4,MARCHF6,SCFD1,BET1,SPTB,ST6GALNAC2,ST3GAL2,GNE,DYNC1H1,RNF103,TFG,SPTBN4,TUSC3,STX17,MGAT1,GMPPB,NUS1,EDEM1,EDEM3,ST3GAL4,UBXN1,STT3A,COG4,SEL1L,DYNLL1,ALG9,PPP6R3,TMED9,ALG14,LMAN1L,RFT1,SPTBN5,B4GALT4,ALG12,MOGS,STX5,ASGR2,RPN2,ARFGAP2,CTSC,SPTAN1,CTSZ,GOLGA2,SEC13,RAB1B,BET1L,TRIM13,UGGT1,TMEM115,RAD23B,ARF1,RPS27A,FUCA1,ST8SIA6,MVD,GFPT2,LMAN2,ALG8,CHST10,ALG2,TRAPPC9,GLB1,CHST8,DCTN4,ARF5,SYVN1,MANEA,PSMC1,B4GALT3,FCSK,TMED7,DOLPP1,RPN1,ST8SIA4,AREG,COG5,RNF5,DYNC1I1,MIR711,UMOD,ALG10B,ANK3,CNIH3,RNF139,MIA2,ST6GALNAC1,B4GALT2,MGAT4A,COPB2,FOLR1,KDELR1,GOLGB1,CGA,EDEM2,NAPB,NAGK,GFUS,ST3GAL5,CNIH2,SEC22B,DCTN6,ANK2,DPM2,COL7A1,COG6,SEC23A,ALG1,SLC35A1,ST3GAL1,GNPNAT1,FUT8,COPG1,SEC24A,NAPG,MCFD2,DYNC1I2,MPDU1,MAN2A1,DDOST,OS9,MAN1A2,YKT6,ST6GALNAC3,COPB1,COG3,ALG6,COG2,ST8SIA3,CANX,DOLK,PREB,DPM3,PMM2,DYNC1LI2,ST6GALNAC5,LHB,SEC24D,UBC,ST6GALNAC6,ASGR1,CNIH1,COPG2,NEU3,MGAT2,UAP1,SEC24B,GMPPA,CD59,PPP6C,DYNC1LI1,DCTN5,RNF185,KDELR2,UGGT2,MAN1A1,FUT3,TRAPPC3,ARFGAP3,CMAS,SPTBN2,ARFGAP1,DCTN3,PRKCSH,TRAPPC6B,GMDS,NEU1,TGFA,SEC23IP,ST8SIA1,TMED2,CSNK1D,COPZ1,COG8,NANS,GOSR2,TRAPPC10,SRD5A3,GFPT1,ST3GAL3,GBF1,DYNLL2,ST6GAL2,COG7,USO1,SPTBN1,ST3GAL6,KDELR3,UBA52,MAN2A2,COPE,DCTN1,PGM3,B4GALNT2,B4GALT1,ARCN1,ALG3,NPL,MIA3,TMED3,MGAT5,MPI,B4GALT5,ALG10,ST6GAL1,CD55,CALR,NGLY1,COG1,ENGASE,NSF,TBC1D20,DPM1,SEC24C,ANK1,DCTN2,LMAN1,DAD1,MGAT3,GANAB,TRAPPC1,SEC16B,INS,FPGT,B4GALT6,MGAT4B,SEC31A,DHDDS,MLEC,ST6GALNAC4,SERPINA1,UBB,MGAT4C,NANP,PMM1,ST8SIA2,GRIA1,COPZ2
R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	0.0654578758955211	-2.72634845932771	21	21	0.00232455169360195	9034	10285	4850,9337,57472,23019,995,55571,246175,5325,10769,55835,4848,85456,4869,29883,9125,7832,28984,25904,7157,4849,1263	CNOT4,CNOT8,CNOT6,CNOT1,CDC25C,CNOT11,CNOT6L,PLAGL1,PLK2,CENPJ,CNOT2,TNKS1BP1,NPM1,CNOT7,CNOT9,BTG2,RGCC,CNOT10,TP53,CNOT3,PLK3
R-HSA-210745	Regulation of gene expression in beta cells	0.0654578758955211	-2.72634845932771	21	21	0.00232455169360195	9034	10285	10000,3375,4821,5080,6514,3171,2308,4825,2645,3651,3170,4760,389692,3172,207,3174,6927,3630,5313,222546,208	AKT3,IAPP,NKX2-2,PAX6,SLC2A2,FOXA3,FOXO1,NKX6-1,GCK,PDX1,FOXA2,NEUROD1,MAFA,HNF4A,AKT1,HNF4G,HNF1A,INS,PKLR,RFX6,AKT2
R-HSA-5654688	SHC-mediated cascade:FGFR1	0.0654578758955211	-2.72634845932771	21	21	0.00232455169360195	9034	10285	2885,4893,2251,2249,2246,2255,27006,9365,2248,26281,3265,3845,2260,6464,8074,2253,2254,2247,2250,6654,8822	GRB2,NRAS,FGF6,FGF4,FGF1,FGF10,FGF22,KL,FGF3,FGF20,HRAS,KRAS,FGFR1,SHC1,FGF23,FGF8,FGF9,FGF2,FGF5,SOS1,FGF17
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	0.0654578758955211	-2.72634845932771	21	21	0.00232455169360195	9034	10285	2999,3481,1511,3817,5069,5340,60676,3487,26085,3485,354,3488,3484,3483,4313,3816,3479,2147,4312,3489,3486	GZMH,IGF2,CTSG,KLK2,PAPPA,PLG,PAPPA2,IGFBP4,KLK13,IGFBP2,KLK3,IGFBP5,IGFBP1,IGFALS,MMP2,KLK1,IGF1,F2,MMP1,IGFBP6,IGFBP3
R-HSA-5654689	PI-3K cascade:FGFR1	0.0654578758955211	-2.72634845932771	21	21	0.00232455169360195	9034	10285	5290,8822,2250,2254,2253,8074,5781,2247,2260,10818,5295,27006,2255,9365,26281,2248,2251,2249,2246,2549,2885	PIK3CA,FGF17,FGF5,FGF9,FGF8,FGF23,PTPN11,FGF2,FGFR1,FRS2,PIK3R1,FGF22,FGF10,KL,FGF20,FGF3,FGF6,FGF4,FGF1,GAB1,GRB2
R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic	0.0688766411673207	-2.67543818359228	179	164	0.0181536417976533	9034	10285	381,51164,4122,9341,11316,1639,10749,54734,3831,5321,10244,60561,51014,372,5048,2803,55614,23423,10466,23095,1780,22931,10618,9321,23303,3798,122830,23299,29127,51272,81876,9570,8729,81930,60592,140735,636,91949,375,51594,3482,23046,147700,3833,9950,5870,8398,9585,547,11015,27314,9554,79571,10671,11004,27333,9267,22930,9265,26153,57511,2590,3834,60560,53407,23647,9266,51226,5049,662,9382,4905,64837,10226,9183,9276,55605,56992,10112,10945,83452,55582,3799,10540,63908,7110,8677,8675,10228,64147,89953,10905,22920,10652,3797,84316,124602,378,250,3835,56894,51560,1315,83548,22796,25782,3796,221458,1783,1778,1062,2800,8674,22820,8774,1781,4124,377,5861,10972,2589,9493,57134,9527,54732,27128,11127,26286,9712,55275,9648,6811,55738,4074,11311,55083,11258,113220,738,55850,84364,51542,285643,10959,9609,84342,22818,26958,84643,57589,1523,6836,90196,51143,84516,146909,11014,22836,3832,25839,339122,400,8655,4121	ARF5,DCTN4,MAN2A2,VAMP3,COPE,DCTN1,KIF1C,RAB39A,KLC1,PLA2G4A,RABEPK,RINT1,TMED7,ARCN1,PAFAH1B1,GOLGA4,KIF16B,TMED3,COG5,KIF1B,DYNC1I1,RAB18,TGOLN2,TRIP11,KIF13B,KIF5A,NAA30,BICD2,RACGAP1,BET1L,RAB1B,GOSR2,GBF1,KIF18A,SCOC,DYNLL2,BICD1,COG7,ARF1,NBAS,IGF2R,KIF21B,KLC3,KIFC1,GOLGA5,RAB6A,PLA2G6,KIF20B,KIF1A,KDELR3,RAB30,SEC22B,GCC1,DCTN6,KIF2C,GOLIM4,CYTH1,RAB3GAP1,CYTH3,KIF26A,COG6,GALNT2,KIF25,NAA35,STX18,ARFIP2,CYTH2,COPZ2,PAFAH1B2,BNIP1,COG1,NSF,KLC2,PLIN3,ZW10,COPB2,KIF21A,KIF15,KIF20A,KDELR1,RAB33B,KIF27,KIF5B,DCTN2,NAPB,TMF1,STX10,STX16,STX6,KIF9,KLC4,MAN1A2,KIFAP3,YKT6,KIF3C,NAA38,KIF19,ARF4,ALPP,KIF22,AGPAT3,RAB6B,COPB1,COG3,COG2,RAB3GAP2,KIF2A,KIF6,DYNC1LI2,DYNC1H1,CENPE,GOLGA1,VAMP4,COPG1,NAPG,DYNC1I2,MAN2A1,ARF3,RAB1A,TMED10,GALNT1,KIF23,MAN1C1,GOSR1,TMED9,CYTH4,KIF3A,ARFGAP3,USP6NL,VPS53,GCC2,STX5,ARFGAP1,M6PR,VPS45,KIF26B,DCTN3,KIF12,VPS51,USE1,ARFGAP2,VPS54,KIF4B,TMED2,RAB36,COG8,COPZ1,COPG2,KIF2B,RIC1,CUX1,SURF4,SYS1,DYNC1LI1,DCTN5,KIF18B,KDELR2,RHOBTB3,KIF11,COG4,RAB43,ARL1,DYNLL1,MAN1A1
R-HSA-192105	Synthesis of bile acids and bile salts	0.0691035565332384	-2.67214908016632	34	33	0.00365286694708878	9034	10285	6718,1582,1109,1646,114881,9023,114880,6256,5007,80270,9885,5740,23600,1645,6342,8647,26031,11001,10005,51302,114883,9971,10858,114876,1593,10499,8309,3295,1581,9420,8648,570,8644	AKR1D1,CYP8B1,AKR1C4,AKR1C2,OSBPL7,CH25H,OSBPL6,RXRA,OSBP,HSD3B7,OSBPL2,PTGIS,AMACR,AKR1C1,SCP2,ABCB11,OSBPL3,SLC27A2,ACOT8,CYP39A1,OSBPL9,NR1H4,CYP46A1,OSBPL1A,CYP27A1,NCOA2,ACOX2,HSD17B4,CYP7A1,CYP7B1,NCOA1,BAAT,AKR1C3
R-HSA-73847	Purine metabolism	0.0691035565332384	-2.67214908016632	34	33	0.00365286694708878	9034	10285	3615,30833,84618,51292,132,272,5471,159,2618,1716,8833,1633,122622,3614,471,5198,847,4860,64077,100,22978,2766,270,10606,7498,2876,158,9615,93034,4907,161823,271,353	IMPDH2,NT5C,NT5C1A,GMPR2,ADK,AMPD3,PPAT,ADSS2,GART,DGUOK,GMPS,DCK,ADSS1,IMPDH1,ATIC,PFAS,CAT,PNP,LHPP,ADA,NT5C2,GMPR,AMPD1,PAICS,XDH,GPX1,ADSL,GDA,NT5C1B,NT5E,ADAL,AMPD2,APRT
R-HSA-159227	Transport of the SLBP independent Mature mRNA	0.0691035565332384	-2.67214908016632	34	33	0.00365286694708878	9034	10285	57122,4686,55746,23225,9972,79902,53371,23279,22916,1977,23511,348995,5903,100101267,23165,23636,10762,9818,129401,4928,7175,10189,9688,55706,8086,11097,10482,9631,81929,8021,9883,79023,4927	NUP107,NCBP1,NUP133,NUP210,NUP153,NUP85,NUP54,NUP160,NCBP2,EIF4E,NUP188,NUP43,RANBP2,POM121C,NUP205,NUP62,NUP50,NUP58,NUP35,NUP98,TPR,ALYREF,NUP93,NDC1,AAAS,NUP42,NXF1,NUP155,SEH1L,NUP214,POM121,NUP37,NUP88
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	0.0691035565332384	-2.67214908016632	34	33	0.00365286694708878	9034	10285	55746,57122,7514,53371,9972,23225,79902,23511,5902,348995,23279,10762,5903,23636,100101267,23165,129401,9818,5905,7175,4928,81929,9631,55706,5901,9688,11097,8086,79023,9883,8021,1104,4927	NUP133,NUP107,XPO1,NUP54,NUP153,NUP210,NUP85,NUP188,RANBP1,NUP43,NUP160,NUP50,RANBP2,NUP62,POM121C,NUP205,NUP35,NUP58,RANGAP1,TPR,NUP98,SEH1L,NUP155,NDC1,RAN,NUP93,NUP42,AAAS,NUP37,POM121,NUP214,RCC1,NUP88
R-HSA-5673001	RAF/MAP kinase cascade	0.070167591990435	-2.65686872710263	245	223	0.0246845251272969	9034	10285	152559,9978,5713,10256,64926,153090,4902,5684,805,26281,5699,7311,10818,5595,409,2668,10142,2905,6711,8649,8826,4684,673,3815,5711,2906,2248,10718,5706,2266,80824,1445,4140,7314,5515,8822,3718,5922,4296,5906,2885,2674,5747,1850,2249,9462,4763,1847,399473,3567,5702,5516,5714,816,3560,4747,5979,8452,5698,54518,10213,6714,7316,5159,2675,2263,2069,10817,2903,9491,10197,2676,5923,2261,5701,2247,161742,2335,2250,1849,9965,6654,5526,5921,200734,808,84292,7529,145957,5525,5715,5682,5594,1848,3568,3717,5685,221002,6712,1742,5690,5686,1839,1956,8315,10156,2264,5704,2904,5924,6464,408,9048,1437,4233,3082,25780,2251,28956,2243,9365,27006,4254,3559,5700,2260,5718,5528,2253,6233,5605,3562,5707,8682,84078,5694,3265,100847012,3674,2254,64096,1846,9693,7450,5529,5719,817,5693,2534,8660,5156,8074,5691,27040,2065,54756,3558,8437,2066,818,7414,5155,25759,2244,11221,5720,23198,88,7979,1844,10125,143471,5710,122706,4893,6710,5692,2255,685,7010,6708,3690,10048,5154,283455,3667,5708,115727,2246,53358,9861,2064,5717,3084,5527,5519,801,5245,6709,1950,5037,5894,9542,8817,5687,51332,815,5518,5786,3716,3845,5908,284,8831,1843,2252,5695,5623,5604,57731,5696,1439,5536	PAQR3,RBX1,PSMD7,CNKSR1,RASAL3,DAB2IP,NRTN,PSMA3,CALM2,FGF20,PSMB10,UBA52,FRS2,MAPK3,ARRB2,GDNF,AKAP9,GRIN2C,SPTBN1,LAMTOR3,IQGAP1,NCAM1,BRAF,KIT,PSMD5,GRIN2D,FGF3,NRG3,PSMC6,FGG,DUSP16,CSK,MARK3,UBB,PPP2CA,FGF17,JAK3,RASA2,MAP3K11,RAP1A,GRB2,GFRA1,PTK2,DUSP8,FGF4,RASAL2,NF1,DUSP5,SPRED3,IL5,PSMC3,PPP2CB,PSMD8,CAMK2B,IL2RB,NEFL,RET,CUL3,PSMB9,APBB1IP,PSMD14,SRC,UBC,PDGFRB,GFRA2,FGFR2,EREG,FRS3,GRIN2A,PSMF1,PSME3,GFRA3,RASGRF1,FGFR3,PSMC2,FGF2,SPRED1,FN1,FGF5,DUSP7,FGF19,SOS1,PPP2R5B,RASA1,SPRED2,CALM3,WDR83,YWHAB,NRG4,PPP2R5A,PSMD9,PSMA1,MAPK1,DUSP6,IL5RA,JAK2,PSMA4,RASGEF1A,SPTBN2,DLG4,PSMB2,PSMA5,HBEGF,EGFR,BRAP,RASA4,FGFR4,PSMC4,GRIN2B,RASGRF2,SHC1,ARRB1,ARTN,CSF2,MET,HGF,RASGRP3,FGF6,LAMTOR2,FGA,KL,FGF22,KITLG,IL2RA,PSMC1,FGFR1,PSMD12,PPP2R5D,FGF8,RPS27A,MAP2K2,IL3,PSMD1,PEA15,KBTBD7,PSMB6,HRAS,MIR5004,ITGA2B,FGF9,GFRA4,DUSP4,RAPGEF2,VWF,PPP2R5E,PSMD13,CAMK2D,PSMB5,FYN,IRS2,PDGFRA,FGF23,PSMB3,LAT,ERBB3,IL17RD,IL2,RASAL1,ERBB4,CAMK2G,VCL,PDGFB,SHC2,FGB,DUSP10,PSME1,PSME4,ACTN2,SEM1,DUSP2,RASGRP1,PSMA8,PSMD4,PSMB11,NRAS,SPTB,PSMB4,FGF10,BTC,TEK,SPTA1,ITGB3,RANBP9,PDGFA,KSR2,IRS1,PSMD2,RASGRP4,FGF1,SHC3,PSMD6,ERBB2,PSMD11,NRG1,PPP2R5C,PPP2R1B,CALM1,PHB1,SPTAN1,EGF,PEBP1,RAF1,NRG2,FGF18,PSMA6,SPTBN5,CAMK2A,PPP2R1A,PTPRA,JAK1,KRAS,RAP1B,ANGPT1,SYNGAP1,DUSP1,FGF7,PSMB7,PSPN,MAP2K1,SPTBN4,PSMB8,CSF2RB,PPP5C
R-HSA-112412	SOS-mediated signalling	0.070167591990435	-2.65686872710263	245	223	0.0246845251272969	9034	10285	6712,1742,5690,5686,5594,1848,3568,5685,3717,221002,2264,10156,5704,2904,6464,5924,1956,1839,8315,2263,10817,2069,2903,10197,2676,9491,5923,7316,5159,2675,808,200734,84292,7529,145957,5682,5715,5525,2261,5701,2247,161742,2335,2250,1849,9965,5526,6654,5921,4296,5922,3718,5747,2674,5906,2885,1850,2249,9462,4763,1847,3567,399473,5702,5516,80824,1445,4140,7314,8822,5515,8452,5979,5698,54518,10213,6714,5714,816,3560,4747,5684,805,5699,26281,7311,5595,10818,9978,152559,10256,5713,64926,153090,4902,3815,5711,2906,2248,10718,5706,2266,409,2905,10142,2668,8649,6711,8826,673,4684,51332,815,5518,5786,3716,5908,3845,801,5245,6709,1950,5037,5894,5687,9542,8817,5623,5604,5696,57731,1439,5536,284,8831,1843,2252,5695,122706,4893,6710,5692,2255,88,23198,7979,1844,10125,5710,143471,5708,115727,2246,9861,53358,2064,5527,3084,5717,5519,685,7010,3690,6708,283455,10048,5154,3667,817,5693,2534,64096,2254,100847012,3674,7450,1846,9693,5529,5719,3558,8437,7414,818,2066,5155,25759,2244,11221,5720,8660,5156,2065,5691,27040,8074,54756,3082,25780,28956,2251,9365,27006,2243,5700,4254,3559,2260,408,9048,1437,4233,8682,84078,5694,3265,5718,5528,2253,3562,6233,5605,5707	SPTBN2,DLG4,PSMB2,PSMA5,MAPK1,DUSP6,IL5RA,PSMA4,JAK2,RASGEF1A,FGFR4,RASA4,PSMC4,GRIN2B,SHC1,RASGRF2,EGFR,HBEGF,BRAP,FGFR2,FRS3,EREG,GRIN2A,PSME3,GFRA3,PSMF1,RASGRF1,UBC,PDGFRB,GFRA2,CALM3,SPRED2,WDR83,YWHAB,NRG4,PSMA1,PSMD9,PPP2R5A,FGFR3,PSMC2,FGF2,SPRED1,FN1,FGF5,DUSP7,FGF19,PPP2R5B,SOS1,RASA1,MAP3K11,RASA2,JAK3,PTK2,GFRA1,RAP1A,GRB2,DUSP8,FGF4,RASAL2,NF1,DUSP5,IL5,SPRED3,PSMC3,PPP2CB,DUSP16,CSK,MARK3,UBB,FGF17,PPP2CA,CUL3,RET,PSMB9,APBB1IP,PSMD14,SRC,PSMD8,CAMK2B,IL2RB,NEFL,PSMA3,CALM2,PSMB10,FGF20,UBA52,MAPK3,FRS2,RBX1,PAQR3,CNKSR1,PSMD7,RASAL3,DAB2IP,NRTN,KIT,PSMD5,GRIN2D,FGF3,NRG3,PSMC6,FGG,ARRB2,GRIN2C,AKAP9,GDNF,LAMTOR3,SPTBN1,IQGAP1,BRAF,NCAM1,SPTBN5,CAMK2A,PPP2R1A,PTPRA,JAK1,RAP1B,KRAS,CALM1,PHB1,SPTAN1,EGF,PEBP1,RAF1,PSMA6,NRG2,FGF18,PSPN,MAP2K1,PSMB8,SPTBN4,CSF2RB,PPP5C,ANGPT1,SYNGAP1,DUSP1,FGF7,PSMB7,PSMB11,NRAS,SPTB,PSMB4,FGF10,ACTN2,PSME4,SEM1,DUSP2,RASGRP1,PSMD4,PSMA8,PSMD2,RASGRP4,FGF1,PSMD6,SHC3,ERBB2,PPP2R5C,NRG1,PSMD11,PPP2R1B,BTC,TEK,ITGB3,SPTA1,KSR2,RANBP9,PDGFA,IRS1,CAMK2D,PSMB5,FYN,GFRA4,FGF9,MIR5004,ITGA2B,VWF,DUSP4,RAPGEF2,PPP2R5E,PSMD13,IL2,RASAL1,VCL,CAMK2G,ERBB4,PDGFB,SHC2,FGB,DUSP10,PSME1,IRS2,PDGFRA,ERBB3,PSMB3,LAT,FGF23,IL17RD,HGF,RASGRP3,LAMTOR2,FGF6,KL,FGF22,FGA,PSMC1,KITLG,IL2RA,FGFR1,ARRB1,ARTN,CSF2,MET,PEA15,KBTBD7,PSMB6,HRAS,PSMD12,PPP2R5D,FGF8,IL3,RPS27A,MAP2K2,PSMD1
R-HSA-179812	GRB2 events in EGFR signaling	0.070167591990435	-2.65686872710263	245	223	0.0246845251272969	9034	10285	9048,1437,4233,408,2243,27006,9365,4254,3559,5700,2260,3082,2251,28956,25780,6233,5605,3562,5707,5718,5528,2253,3265,8682,84078,5694,1846,7450,9693,5719,5529,100847012,3674,64096,2254,817,5693,2534,54756,8660,5156,8074,27040,5691,2065,25759,2244,11221,5720,3558,8437,2066,818,7414,5155,10125,143471,5710,23198,88,7979,1844,5692,2255,122706,4893,6710,6708,3690,5154,10048,283455,3667,685,7010,2064,5527,3084,5717,5519,5708,115727,2246,53358,9861,5894,9542,8817,5687,801,5245,6709,1950,5037,5786,3716,3845,5908,815,51332,5518,2252,5695,284,8831,1843,57731,5696,1439,5536,5623,5604,153090,4902,152559,9978,5713,10256,64926,5699,26281,7311,5595,10818,5684,805,6711,8649,8826,4684,673,409,10142,2668,2905,2248,10718,5706,2266,3815,5711,2906,7314,5515,8822,80824,1445,4140,4763,1847,399473,3567,5702,5516,3718,5922,4296,2674,2885,5906,5747,1850,2249,9462,3560,4747,5714,816,10213,6714,5979,8452,5698,54518,2675,5159,7316,2903,9491,10197,2676,5923,2263,2069,10817,2250,1849,9965,6654,5526,5921,2261,5701,2247,161742,2335,84292,145957,7529,5525,5715,5682,200734,808,3717,5685,221002,5594,1848,3568,5690,5686,6712,1742,8315,1839,1956,2904,6464,5924,10156,2264,5704	ARTN,CSF2,MET,ARRB1,FGA,FGF22,KL,KITLG,IL2RA,PSMC1,FGFR1,HGF,FGF6,LAMTOR2,RASGRP3,RPS27A,MAP2K2,IL3,PSMD1,PSMD12,PPP2R5D,FGF8,HRAS,PEA15,KBTBD7,PSMB6,DUSP4,VWF,RAPGEF2,PSMD13,PPP2R5E,MIR5004,ITGA2B,GFRA4,FGF9,CAMK2D,PSMB5,FYN,IL17RD,IRS2,PDGFRA,FGF23,LAT,PSMB3,ERBB3,SHC2,FGB,DUSP10,PSME1,IL2,RASAL1,ERBB4,CAMK2G,VCL,PDGFB,RASGRP1,PSMA8,PSMD4,PSME4,ACTN2,SEM1,DUSP2,PSMB4,FGF10,PSMB11,NRAS,SPTB,SPTA1,ITGB3,PDGFA,RANBP9,KSR2,IRS1,BTC,TEK,ERBB2,PPP2R5C,NRG1,PSMD11,PPP2R1B,PSMD2,RASGRP4,FGF1,SHC3,PSMD6,RAF1,NRG2,FGF18,PSMA6,CALM1,PHB1,SPTAN1,EGF,PEBP1,PTPRA,JAK1,KRAS,RAP1B,CAMK2A,SPTBN5,PPP2R1A,FGF7,PSMB7,ANGPT1,SYNGAP1,DUSP1,SPTBN4,PSMB8,CSF2RB,PPP5C,PSPN,MAP2K1,DAB2IP,NRTN,PAQR3,RBX1,PSMD7,CNKSR1,RASAL3,PSMB10,FGF20,UBA52,MAPK3,FRS2,PSMA3,CALM2,SPTBN1,LAMTOR3,IQGAP1,NCAM1,BRAF,ARRB2,AKAP9,GDNF,GRIN2C,FGF3,NRG3,PSMC6,FGG,KIT,PSMD5,GRIN2D,UBB,PPP2CA,FGF17,DUSP16,CSK,MARK3,NF1,DUSP5,SPRED3,IL5,PSMC3,PPP2CB,JAK3,RASA2,MAP3K11,GFRA1,GRB2,RAP1A,PTK2,DUSP8,FGF4,RASAL2,IL2RB,NEFL,PSMD8,CAMK2B,PSMD14,SRC,RET,CUL3,PSMB9,APBB1IP,GFRA2,PDGFRB,UBC,GRIN2A,PSMF1,PSME3,GFRA3,RASGRF1,FGFR2,EREG,FRS3,FGF5,DUSP7,FGF19,SOS1,PPP2R5B,RASA1,FGFR3,PSMC2,FGF2,SPRED1,FN1,WDR83,NRG4,YWHAB,PPP2R5A,PSMD9,PSMA1,SPRED2,CALM3,JAK2,PSMA4,RASGEF1A,MAPK1,DUSP6,IL5RA,PSMB2,PSMA5,SPTBN2,DLG4,BRAP,HBEGF,EGFR,GRIN2B,SHC1,RASGRF2,RASA4,FGFR4,PSMC4
R-HSA-180336	SHC1 events in EGFR signaling	0.070167591990435	-2.65686872710263	245	223	0.0246845251272969	9034	10285	2253,5718,5528,5707,5605,6233,3562,5694,84078,8682,3265,408,4233,1437,9048,28956,25780,2251,3082,2260,4254,3559,5700,2243,9365,27006,27040,5691,8074,2065,5156,8660,54756,5155,2066,818,7414,8437,3558,5720,11221,2244,25759,100847012,3674,64096,2254,5719,5529,1846,9693,7450,2534,5693,817,7010,685,3667,5154,10048,283455,6708,3690,53358,9861,2246,115727,5708,5519,5527,3084,5717,2064,1844,7979,23198,88,143471,5710,10125,6710,122706,4893,2255,5692,1843,8831,284,5695,2252,5604,5623,5536,1439,57731,5696,5037,6709,1950,5245,801,8817,9542,5687,5894,5518,815,51332,3845,5908,3716,5786,2668,10142,2905,409,4684,673,8826,6711,8649,2906,5711,3815,2266,5706,10718,2248,64926,5713,10256,152559,9978,4902,153090,805,5684,10818,5595,7311,5699,26281,816,5714,4747,3560,54518,5698,5979,8452,6714,10213,4140,1445,80824,8822,5515,7314,9462,1850,2249,2674,2885,5906,5747,3718,5922,4296,5516,5702,399473,3567,1847,4763,2335,2247,161742,5701,2261,5921,6654,5526,9965,1849,2250,200734,808,5525,5715,5682,145957,7529,84292,5159,7316,2675,2069,10817,2263,5923,9491,2676,10197,2903,1839,1956,8315,5704,10156,2264,5924,6464,2904,3568,1848,5594,221002,3717,5685,1742,6712,5686,5690	FGF8,PSMD12,PPP2R5D,PSMD1,MAP2K2,RPS27A,IL3,PSMB6,KBTBD7,PEA15,HRAS,ARRB1,MET,CSF2,ARTN,LAMTOR2,RASGRP3,FGF6,HGF,FGFR1,KITLG,IL2RA,PSMC1,FGA,KL,FGF22,LAT,PSMB3,FGF23,ERBB3,PDGFRA,IRS2,IL17RD,PDGFB,ERBB4,CAMK2G,VCL,RASAL1,IL2,PSME1,DUSP10,FGB,SHC2,MIR5004,ITGA2B,GFRA4,FGF9,PSMD13,PPP2R5E,DUSP4,RAPGEF2,VWF,FYN,PSMB5,CAMK2D,TEK,BTC,IRS1,PDGFA,RANBP9,KSR2,SPTA1,ITGB3,SHC3,PSMD6,FGF1,RASGRP4,PSMD2,PPP2R1B,PPP2R5C,NRG1,PSMD11,ERBB2,DUSP2,SEM1,PSME4,ACTN2,PSMA8,PSMD4,RASGRP1,SPTB,PSMB11,NRAS,FGF10,PSMB4,DUSP1,SYNGAP1,ANGPT1,PSMB7,FGF7,MAP2K1,PSPN,PPP5C,CSF2RB,SPTBN4,PSMB8,PEBP1,SPTAN1,EGF,PHB1,CALM1,FGF18,NRG2,PSMA6,RAF1,PPP2R1A,CAMK2A,SPTBN5,KRAS,RAP1B,JAK1,PTPRA,GDNF,AKAP9,GRIN2C,ARRB2,NCAM1,BRAF,IQGAP1,SPTBN1,LAMTOR3,GRIN2D,PSMD5,KIT,FGG,PSMC6,NRG3,FGF3,RASAL3,PSMD7,CNKSR1,PAQR3,RBX1,NRTN,DAB2IP,CALM2,PSMA3,FRS2,MAPK3,UBA52,PSMB10,FGF20,CAMK2B,PSMD8,NEFL,IL2RB,APBB1IP,PSMB9,RET,CUL3,SRC,PSMD14,MARK3,CSK,DUSP16,FGF17,PPP2CA,UBB,RASAL2,DUSP8,FGF4,GFRA1,GRB2,RAP1A,PTK2,JAK3,RASA2,MAP3K11,PPP2CB,PSMC3,SPRED3,IL5,DUSP5,NF1,FN1,FGF2,SPRED1,PSMC2,FGFR3,RASA1,SOS1,PPP2R5B,FGF19,DUSP7,FGF5,SPRED2,CALM3,PPP2R5A,PSMD9,PSMA1,NRG4,YWHAB,WDR83,PDGFRB,UBC,GFRA2,EREG,FRS3,FGFR2,RASGRF1,PSMF1,GFRA3,PSME3,GRIN2A,HBEGF,EGFR,BRAP,PSMC4,RASA4,FGFR4,RASGRF2,SHC1,GRIN2B,IL5RA,DUSP6,MAPK1,RASGEF1A,JAK2,PSMA4,DLG4,SPTBN2,PSMA5,PSMB2
R-HSA-76002	Platelet activation, signaling and aggregation	0.0709684623792042	-2.64551969246544	282	256	0.0283373920743857	9034	10285	5291,2792,23533,4352,6464,3710,5196,9564,710,335,5579,55970,5777,5660,83706,5336,2162,334,3481,51571,2149,5770,3708,5594,10000,5293,59345,5170,3568,5099,7534,7409,6915,1606,3717,5874,3273,808,11343,2770,9948,9749,9846,10184,5294,2335,57113,5588,51706,2787,6654,9162,3709,151,998,5478,12,7410,6414,5578,350,391,5345,160851,3932,54518,1432,29789,6714,87,5295,51368,152,81,6403,6810,3560,5054,5296,928,388,3700,2885,5906,5747,3718,3567,1893,7078,10447,7057,8407,1445,308,5627,221955,387,51764,2,5265,213,7040,2788,8527,2793,7273,51097,259215,2266,5216,4067,409,51266,2147,805,351,146850,948,5595,150,5341,57406,2791,5028,5580,5005,5175,1439,2814,23052,22915,5879,7423,29106,6813,54331,8503,5552,11069,747,10451,2207,967,5908,2782,3716,1607,10681,7043,3827,801,1521,1950,5894,1072,5581,10235,10630,6850,2790,2786,78991,2767,5340,7044,813,5154,2811,3690,2153,55664,22927,2776,2151,10672,10257,88,3959,406974,7424,5583,6814,7277,10125,1191,3479,3309,3558,2784,27154,5155,7414,2244,207,10490,27040,94235,64805,66005,3699,6678,346562,2534,54676,1398,7873,10411,7222,208,197,1608,374354,3674,5768,5781,5267,7450,5582,5290,6647,2769,26090,8525,2773,9630,5919,2768,8526,2815,5004,3562,54495,7422,7225,135228,6694,5590,1609,3082,2783,3671,2243,5321,10487,1675,7123,3559,3937,2771,51206,226,408,5880,1437,7018,7042	PIK3CB,GNGT1,PIK3R5,MPL,SHC1,ITPR3,PF4,BCAR1,SERPING1,APOA1,PRKCB,GNG12,PTPN6,PSAP,FERMT3,PLCG2,F13A1,APLP2,IGF2,CYRIB,F2R,PTPN1,ITPR1,MAPK1,AKT3,PIK3CD,GNB4,PDPK1,IL5RA,PCDH7,YWHAZ,VAV1,TBXA2R,DGKA,JAK2,RAB27B,HRG,CALM3,MGLL,GNAI1,WDR1,PHACTR2,GAB2,LHFPL2,PIK3CG,FN1,TRPC7,PRKCQ,CYB5R1,GNG5,SOS1,DGKI,ITPR2,ADRA2B,CDC42,PPIA,SERPINA3,VAV2,SELENOP,PRKCA,APOH,RHOG,SERPINF2,DGKH,LCK,APBB1IP,MAPK14,OLA1,SRC,ACTN1,PIK3R1,TEX264,ADRA2C,ACTN4,SELP,STX4,IL2RB,SERPINE1,PIK3R2,CD9,RHOB,ITIH4,GRB2,RAP1A,PTK2,JAK3,IL5,ECM1,TIMP3,FAM3C,THBS1,TAGLN2,CSK,ANXA5,PROS1,DAGLB,RHOA,GNG13,A2M,SERPINA1,ALB,TGFB1,GNG7,DGKD,GNGT2,TTN,SCCPDH,LY6G6F,FGG,PFN1,LYN,ARRB2,CLEC1B,F2,CALM2,APP,PIK3R6,CD36,MAPK3,ADRA2A,PLEK,ABHD6,GNG11,P2RY1,PRKCD,ORM2,PECAM1,CSF2RB,GP5,ENDOD1,MMRN1,RAC1,VEGFB,SCG3,STXBP2,GNG2,PIK3R3,SRGN,RAPGEF4,DAGLA,VAV3,FCER1G,CD63,RAP1B,GNB1,JAK1,DGKB,GNB5,TGFB3,KNG1,CALM1,CTSW,EGF,RAF1,CFL1,PRKCE,RASGRP2,PDPN,SYK,GNG10,GNG4,PCYOX1L,GNA11,PLG,LEFTY2,CALU,PDGFA,GP1BA,ITGB3,F5,CDC37L1,HABP4,GNAQ,F2RL2,GNA13,ABCC4,ACTN2,LGALS3BP,MIR197,VEGFC,PRKCH,STXBP3,TUBA4A,RASGRP1,CLU,IGF1,HSPA5,IL2,GNB3,BRPF3,PDGFB,VCL,FGB,AKT1,VTI1B,LAT,GNG8,P2RY12,CHID1,ITIH3,SPARC,GNAT3,FYN,GTPBP2,CRK,MANF,RAPGEF3,TRPC3,AKT2,AHSG,DGKG,NHLRC2,ITGA2B,QSOX1,PTPN11,SERPINA4,VWF,PRKCG,PIK3CA,SOD1,GNA15,ABHD12,DGKZ,GNAI3,GNA14,RARRES2,GNA12,DGKE,GP9,ORM1,IL3,TMX3,VEGFA,TRPC6,CD109,SPP2,PRKCZ,DGKQ,HGF,GNB2,ISLR,FGA,PLA2G4A,CAP1,CFD,CLEC3B,IL2RA,LCP2,GNAI2,GP6,ALDOA,ARRB1,RAC2,CSF2,TF,TGFB2
R-HSA-216083	Integrin cell surface interactions	0.0713198956520011	-2.64057994908416	68	64	0.00708434801859641	9034	10285	2266,3687,1286,375790,3685,3384,50848,999,3681,1285,3690,2335,3673,3693,22801,8174,3688,960,2243,3675,3695,1311,3655,1298,3791,961,3680,4060,1297,3696,3676,1307,1305,682,3683,83700,2244,1299,5175,3386,1284,91522,58494,2200,3381,3672,3679,3385,7087,3684,6696,1605,1282,3383,7412,8516,3689,3682,3371,3694,3674,8515,7057,3339	FGG,ITGAX,COL4A4,AGRN,ITGAV,ICAM2,F11R,CDH1,ITGAD,COL4A3,ITGB3,FN1,ITGA2,ITGB5,ITGA11,MADCAM1,ITGB1,CD44,FGA,ITGA3,ITGB7,COMP,ITGA6,COL9A2,KDR,CD47,ITGA9,LUM,COL9A1,ITGB8,ITGA4,COL16A1,COL13A1,BSG,ITGAL,JAM3,FGB,COL9A3,PECAM1,ICAM4,COL4A2,COL23A1,JAM2,FBN1,IBSP,ITGA1,ITGA7,ICAM3,ICAM5,ITGAM,SPP1,DAG1,COL4A1,ICAM1,VCAM1,ITGA8,ITGB2,ITGAE,TNC,ITGB6,ITGA2B,ITGA10,THBS1,HSPG2
R-HSA-3000178	ECM proteoglycans	0.0716367076316615	-2.63614765996934	57	54	0.00597741864069072	9034	10285	3908,4684,3911,2331,3690,3693,3673,5802,3688,7148,3915,3687,1462,3685,375790,1634,4060,3680,7042,1297,1758,176,63827,7143,4593,3913,1311,1298,3910,6678,4148,3381,3679,5054,1404,4146,4038,100616340,1299,1463,63923,3371,7040,284217,1834,3694,3674,8785,7043,3909,1605,54829,8516,3912	LAMA2,NCAM1,LAMA5,FMOD,ITGB3,ITGB5,ITGA2,PTPRS,ITGB1,TNXB,LAMC1,ITGAX,VCAN,ITGAV,AGRN,DCN,LUM,ITGA9,TGFB2,COL9A1,DMP1,ACAN,BCAN,TNR,MUSK,LAMB2,COMP,COL9A2,LAMA4,SPARC,MATN3,IBSP,ITGA7,SERPINE1,HAPLN1,MATN1,LRP4,MIR4758,COL9A3,NCAN,TNN,TNC,TGFB1,LAMA1,DSPP,ITGB6,ITGA2B,MATN4,TGFB3,LAMA3,DAG1,ASPN,ITGA8,LAMB1
R-HSA-8874081	MET activates PTK2 signaling	0.0745423891791813	-2.59638733313477	20	20	0.00221385875581138	9034	10285	3910,3082,5747,3912,10319,3914,3913,100422894,3918,6714,3675,3673,100616340,3915,3909,3688,4233,3911,3908,284217	LAMA4,HGF,PTK2,LAMB1,LAMC3,LAMB3,LAMB2,MIR4260,LAMC2,SRC,ITGA3,ITGA2,MIR4758,LAMC1,LAMA3,ITGB1,MET,LAMA5,LAMA2,LAMA1
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	0.0745423891791813	-2.59638733313477	20	20	0.00221385875581138	9034	10285	5295,11140,3845,6464,3265,7311,2549,3320,2885,4893,867,6654,5290,6233,7314,1956,1950,7316,100302213,5335	PIK3R1,CDC37,KRAS,SHC1,HRAS,UBA52,GAB1,HSP90AA1,GRB2,NRAS,CBL,SOS1,PIK3CA,RPS27A,UBB,EGFR,EGF,UBC,MIR1181,PLCG1
R-HSA-5637815	Signaling by Ligand-Responsive EGFR Variants in Cancer	0.0745423891791813	-2.59638733313477	20	20	0.00221385875581138	9034	10285	6654,867,5290,7314,6233,1950,7316,1956,100302213,5335,5295,11140,6464,3845,3265,7311,2549,3320,4893,2885	SOS1,CBL,PIK3CA,UBB,RPS27A,EGF,UBC,EGFR,MIR1181,PLCG1,PIK3R1,CDC37,SHC1,KRAS,HRAS,UBA52,GAB1,HSP90AA1,NRAS,GRB2
R-HSA-1643713	Signaling by EGFR in Cancer	0.0745423891791813	-2.59638733313477	20	20	0.00221385875581138	9034	10285	6233,7314,5290,6654,867,100302213,5335,1956,1950,7316,7311,3265,3845,6464,11140,5295,4893,2885,3320,2549	RPS27A,UBB,PIK3CA,SOS1,CBL,MIR1181,PLCG1,EGFR,EGF,UBC,UBA52,HRAS,KRAS,SHC1,CDC37,PIK3R1,NRAS,GRB2,HSP90AA1,GAB1
R-HSA-163560	Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	0.0745423891791813	-2.59638733313477	20	20	0.00221385875581138	9034	10285	5501,2169,5568,11343,5566,2168,857,3991,5499,5346,2171,646486,2170,2172,51099,2167,646480,5567,2173,5500	PPP1CC,FABP2,PRKACG,MGLL,PRKACA,FABP1,CAV1,LIPE,PPP1CA,PLIN1,FABP5,FABP12,FABP3,FABP6,ABHD5,FABP4,FABP9,PRKACB,FABP7,PPP1CB
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	0.0748739181690005	-2.59194967114505	78	73	0.00808058445871153	9034	10285	9126,56160,6612,79023,1912,57332,51564,11097,8554,10274,55706,7486,9688,9818,23137,100101267,6015,672,23165,5903,142,8924,22955,23511,23279,7341,53371,641,9972,23225,8535,54780,7703,9656,648,6613,4927,80012,51588,1029,286053,6045,7329,197370,9883,493861,8021,81929,6996,9631,8086,7175,4928,6672,129401,10762,6117,23636,79677,5371,348995,5885,165918,7508,84733,1911,100500853,79902,5893,55746,9063,57122,7518	SMC3,NSMCE3,SUMO3,NUP37,PHC2,CBX8,HDAC7,NUP42,PIAS1,STAG1,NDC1,WRN,NUP93,NUP58,SMC5,POM121C,RING1,BRCA1,NUP205,RANBP2,PARP1,HERC2,SCMH1,NUP188,NUP160,SUMO1,NUP54,BLM,NUP153,NUP210,CBX4,NSMCE4A,PCGF2,MDC1,BMI1,SUMO2,NUP88,PHC3,PIAS4,CDKN2A,NSMCE2,RNF2,UBE2I,NSMCE1,POM121,EID3,NUP214,SEH1L,TDG,NUP155,AAAS,TPR,NUP98,SP100,NUP35,NUP50,RPA1,NUP62,SMC6,PML,NUP43,RAD21,RNF168,XPC,CBX2,PHC1,MIR3605,NUP85,RAD52,NUP133,PIAS2,NUP107,XRCC4
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling	0.0761933553349029	-2.57448102042106	271	246	0.02723046269648	9034	10285	8660,8074,5691,27040,2065,5156,3635,54756,8437,3558,5155,818,2066,7414,3636,11221,2244,25759,5720,100847012,3674,64096,2254,5781,1846,7450,9693,7525,5290,5719,5529,817,2534,5693,1398,5528,5718,2253,5605,6233,3562,5707,8682,5694,84078,3265,408,1437,9048,4233,3082,2251,28956,25780,2243,27006,9365,2260,3559,4254,5700,8831,284,1843,6776,5695,2252,8503,5604,5623,1439,57731,5696,5536,5245,801,5037,1950,6709,9542,8817,5687,5894,5518,815,51332,5786,3845,5908,3716,7010,2889,685,5154,10048,283455,6708,3690,3667,115727,5708,53358,9861,2246,2064,6850,5519,3084,5717,5527,23198,88,1844,7979,10125,143471,5710,122706,4893,6710,2255,5692,5714,816,3560,5296,4747,5979,8452,54518,5698,6714,10213,5295,80824,4140,1445,7314,867,5515,8822,2674,2885,5906,5747,3718,5922,4296,9462,1850,2249,399473,3567,4763,1847,5516,5702,409,2668,10142,2905,6711,8649,4684,673,8826,5711,3815,2906,5566,10718,2248,4067,2266,5706,5713,10256,152559,9978,64926,29760,153090,4902,805,5684,7311,26281,5699,10818,5595,1839,1956,8315,5777,5704,10156,2264,5291,6777,2904,5924,6464,5293,5594,3568,7534,1848,7409,221002,3717,5685,1742,6712,5690,5686,5701,9846,2261,2335,2247,161742,9965,2250,1849,5921,6654,5526,200734,808,7529,145957,84292,5715,5525,5682,5159,7316,2675,2263,2069,10817,2903,5923,9491,10197,2676	IRS2,FGF23,PSMB3,LAT,ERBB3,PDGFRA,INPP5D,IL17RD,RASAL1,IL2,PDGFB,CAMK2G,ERBB4,VCL,INPPL1,DUSP10,FGB,SHC2,PSME1,MIR5004,ITGA2B,GFRA4,FGF9,PTPN11,DUSP4,VWF,RAPGEF2,YES1,PIK3CA,PSMD13,PPP2R5E,CAMK2D,FYN,PSMB5,CRK,PPP2R5D,PSMD12,FGF8,MAP2K2,RPS27A,IL3,PSMD1,PEA15,PSMB6,KBTBD7,HRAS,ARRB1,CSF2,ARTN,MET,HGF,FGF6,LAMTOR2,RASGRP3,FGA,FGF22,KL,FGFR1,IL2RA,KITLG,PSMC1,SYNGAP1,ANGPT1,DUSP1,STAT5A,PSMB7,FGF7,PIK3R3,MAP2K1,PSPN,CSF2RB,SPTBN4,PSMB8,PPP5C,PHB1,CALM1,PEBP1,EGF,SPTAN1,NRG2,FGF18,PSMA6,RAF1,PPP2R1A,CAMK2A,SPTBN5,PTPRA,KRAS,RAP1B,JAK1,TEK,RAPGEF1,BTC,PDGFA,RANBP9,KSR2,SPTA1,ITGB3,IRS1,RASGRP4,PSMD2,SHC3,PSMD6,FGF1,ERBB2,SYK,PPP2R1B,NRG1,PSMD11,PPP2R5C,PSME4,ACTN2,DUSP2,SEM1,RASGRP1,PSMA8,PSMD4,PSMB11,NRAS,SPTB,FGF10,PSMB4,PSMD8,CAMK2B,IL2RB,PIK3R2,NEFL,RET,CUL3,APBB1IP,PSMB9,SRC,PSMD14,PIK3R1,DUSP16,MARK3,CSK,UBB,CBL,PPP2CA,FGF17,GFRA1,GRB2,RAP1A,PTK2,JAK3,RASA2,MAP3K11,RASAL2,DUSP8,FGF4,SPRED3,IL5,NF1,DUSP5,PPP2CB,PSMC3,ARRB2,GDNF,AKAP9,GRIN2C,SPTBN1,LAMTOR3,NCAM1,BRAF,IQGAP1,PSMD5,KIT,GRIN2D,PRKACA,NRG3,FGF3,LYN,FGG,PSMC6,PSMD7,CNKSR1,PAQR3,RBX1,RASAL3,BLNK,DAB2IP,NRTN,CALM2,PSMA3,UBA52,FGF20,PSMB10,FRS2,MAPK3,HBEGF,EGFR,BRAP,PTPN6,PSMC4,RASA4,FGFR4,PIK3CB,STAT5B,GRIN2B,RASGRF2,SHC1,PIK3CD,MAPK1,IL5RA,YWHAZ,DUSP6,VAV1,RASGEF1A,JAK2,PSMA4,DLG4,SPTBN2,PSMB2,PSMA5,PSMC2,GAB2,FGFR3,FN1,FGF2,SPRED1,FGF19,FGF5,DUSP7,RASA1,SOS1,PPP2R5B,SPRED2,CALM3,YWHAB,NRG4,WDR83,PSMD9,PPP2R5A,PSMA1,PDGFRB,UBC,GFRA2,FGFR2,EREG,FRS3,GRIN2A,RASGRF1,PSMF1,PSME3,GFRA3
R-HSA-180746	Nuclear import of Rev protein	0.0767902643504362	-2.5666774131344	33	32	0.00354217400929821	9034	10285	4927,1104,9883,8021,3837,79023,11097,8086,55706,9688,5901,81929,9631,4928,7175,129401,9818,23165,100101267,23636,5903,10762,23279,348995,23511,79902,9972,23225,53371,4869,57122,55746	NUP88,RCC1,POM121,NUP214,KPNB1,NUP37,NUP42,AAAS,NDC1,NUP93,RAN,SEH1L,NUP155,NUP98,TPR,NUP35,NUP58,NUP205,POM121C,NUP62,RANBP2,NUP50,NUP160,NUP43,NUP188,NUP85,NUP153,NUP210,NUP54,NPM1,NUP107,NUP133
R-HSA-186712	Regulation of beta-cell development	0.0767902643504362	-2.5666774131344	33	32	0.00354217400929821	9034	10285	2255,3630,3280,3174,208,5313,222546,3642,4760,3651,2308,6514,3171,4825,4821,3375,10000,3175,207,6927,2645,3170,389692,2494,3172,5078,3516,50674,5080,390874,256297,6928	FGF10,INS,HES1,HNF4G,AKT2,PKLR,RFX6,INSM1,NEUROD1,PDX1,FOXO1,SLC2A2,FOXA3,NKX6-1,NKX2-2,IAPP,AKT3,ONECUT1,AKT1,HNF1A,GCK,FOXA2,MAFA,NR5A2,HNF4A,PAX4,RBPJ,NEUROG3,PAX6,ONECUT3,PTF1A,HNF1B
R-HSA-180910	Vpr-mediated nuclear import of PICs	0.0767902643504362	-2.5666774131344	33	32	0.00354217400929821	9034	10285	3836,9818,129401,7175,4928,9631,81929,9688,8815,55706,8086,11097,79023,8021,9883,4927,55746,57122,53371,9972,23225,79902,23511,348995,3159,23279,11168,10762,5903,100101267,23165,23636	KPNA1,NUP58,NUP35,TPR,NUP98,NUP155,SEH1L,NUP93,BANF1,NDC1,AAAS,NUP42,NUP37,NUP214,POM121,NUP88,NUP133,NUP107,NUP54,NUP153,NUP210,NUP85,NUP188,NUP43,HMGA1,NUP160,PSIP1,NUP50,RANBP2,POM121C,NUP205,NUP62
R-HSA-392518	Signal amplification	0.0767902643504362	-2.5666774131344	33	32	0.00354217400929821	9034	10285	2783,2782,5321,10672,2776,59345,2791,2771,406974,10681,2769,6915,51764,5028,9630,2793,2773,2784,2788,2767,2786,2770,2790,2792,1432,6714,94235,346562,2787,55970,54331,64805	GNB2,GNB1,PLA2G4A,GNA13,GNAQ,GNB4,GNG11,GNAI2,MIR197,GNB5,GNA15,TBXA2R,GNG13,P2RY1,GNA14,GNGT2,GNAI3,GNB3,GNG7,GNA11,GNG4,GNAI1,GNG10,GNGT1,MAPK14,SRC,GNG8,GNAT3,GNG5,GNG12,GNG2,P2RY12
R-HSA-1638074	Keratan sulfate/keratin metabolism	0.0767902643504362	-2.5666774131344	33	32	0.00354217400929821	9034	10285	9334,10678,6482,176,6483,4060,23563,8702,5549,9331,93010,2683,79369,3074,2720,8703,9435,4958,10402,10331,2331,6484,4166,79411,6487,11081,11041,2799,4969,11046,8534,8704	B4GALT5,B3GNT2,ST3GAL1,ACAN,ST3GAL2,LUM,CHST5,B4GALT4,PRELP,B4GALT6,B3GNT7,B4GALT1,B3GNT4,HEXB,GLB1,B4GALT3,CHST2,OMD,ST3GAL6,B3GNT3,FMOD,ST3GAL4,CHST6,GLB1L,ST3GAL3,KERA,B4GAT1,GNS,OGN,SLC35D2,CHST1,B4GALT2
R-HSA-389356	CD28 co-stimulation	0.0767902643504362	-2.5666774131344	33	32	0.00354217400929821	9034	10285	79109,57761,2534,2885,64223,998,208,942,5170,10000,55615,5290,7525,7409,1326,5062,3932,5295,4067,253260,207,117145,9020,6714,940,9402,5879,8503,5296,5058,2475,941	MAPKAP1,TRIB3,FYN,GRB2,MLST8,CDC42,AKT2,CD86,PDPK1,AKT3,PRR5,PIK3CA,YES1,VAV1,MAP3K8,PAK2,LCK,PIK3R1,LYN,RICTOR,AKT1,THEM4,MAP3K14,SRC,CD28,GRAP2,RAC1,PIK3R3,PIK3R2,PAK1,MTOR,CD80
R-HSA-163359	Glucagon signaling in metabolic regulation	0.0767902643504362	-2.5666774131344	33	32	0.00354217400929821	9034	10285	2791,59345,2642,5576,108,112,51764,2778,114,2783,5575,5577,2782,113,94235,5573,196883,2787,55970,107,109,115,5567,54331,5568,2784,2788,2641,2786,2790,5566,111	GNG11,GNB4,GCGR,PRKAR2A,ADCY2,ADCY6,GNG13,GNAS,ADCY8,GNB2,PRKAR1B,PRKAR2B,GNB1,ADCY7,GNG8,PRKAR1A,ADCY4,GNG5,GNG12,ADCY1,ADCY3,ADCY9,PRKACB,GNG2,PRKACG,GNB3,GNG7,GCG,GNG4,GNG10,PRKACA,ADCY5
R-HSA-446728	Cell junction organization	0.0770593833612992	-2.56317894187559	88	82	0.00907682089882665	9034	10285	5817,3909,4301,253559,5829,10979,3611,57863,25945,7122,84612,3987,5010,977,26285,667,5818,1004,1366,64398,149461,1012,5584,84552,6251,9069,1009,1365,1002,1495,100422894,3914,87,7016,81607,1005,1016,1007,24146,29780,10686,1499,23705,64403,1001,137075,1015,1006,51208,3691,9073,2318,1500,1308,3655,1008,3688,3728,56288,1010,53842,49861,7408,9071,54751,55742,55679,1013,23562,10207,283,1364,5819,1000,5339,100126326,999,9076,50848,3918,1003,9080	PVR,LAMA3,AFDN,CADM2,PXN,FERMT2,ILK,CADM3,NECTIN3,CLDN5,PARD6B,LIMS1,CLDN11,CD151,CLDN17,DST,NECTIN1,CDH6,CLDN7,PALS1,CLDN19,CDH13,PRKCI,PARD6G,RSU1,CLDN12,CDH11,CLDN3,CDH4,CTNNA1,MIR4260,LAMB3,ACTN1,TESK1,NECTIN4,CDH7,CDH18,CDH9,CLDN15,PARVB,CLDN16,CTNNB1,CADM1,CDH24,CDH3,CLDN23,CDH17,CDH8,CLDN18,ITGB4,CLDN8,FLNC,CTNND1,COL17A1,ITGA6,CDH10,ITGB1,JUP,PARD3,CDH12,CLDN22,CLDN20,VASP,CLDN10,FBLIM1,PARVA,LIMS2,CDH15,CLDN14,PATJ,ANG,CLDN4,NECTIN2,CDH2,PLEC,MIR936,CDH1,CLDN1,F11R,LAMC2,CDH5,CLDN9
R-HSA-169893	Prolonged ERK activation events	0.0775824052103401	-2.55641461448183	252	229	0.0253486827540403	9034	10285	4296,3718,5922,5747,2885,5906,2674,2249,1850,9462,1847,4763,3567,399473,5702,5516,80824,1445,4140,7314,8822,5515,8452,5979,5698,54518,10213,6714,5714,816,3560,4747,5684,805,26281,5699,7311,10818,5595,9978,152559,10256,5713,64926,153090,4902,3815,5711,4914,2906,2248,10718,5706,2266,409,2905,10142,2668,8649,6711,8826,673,4684,6712,1742,5690,5686,5594,5335,1848,3568,5685,3717,221002,2264,10156,5704,2904,6464,5924,1956,1839,8315,2263,10817,2069,2903,10197,2676,9491,5923,7316,5159,2675,808,200734,84292,145957,7529,5682,5525,5715,2261,5701,161742,2247,2335,2250,1849,9965,5526,6654,5921,817,4803,2534,5693,1398,64096,2254,3674,100847012,7450,9693,1846,5529,5719,3558,8437,7414,818,2066,5155,25759,11221,2244,5720,8660,5156,2065,27040,8074,5691,54756,3082,28956,2251,25780,9365,27006,2243,5700,3559,4254,2260,408,9048,1437,4233,8682,84078,5694,3265,5528,5718,2253,3562,5605,6233,5707,51332,815,5518,57498,5786,3716,5908,3845,801,5245,6709,1950,5037,5894,5687,9542,8817,5623,5604,5696,57731,1439,5536,284,8831,1843,2252,5695,4893,122706,6710,5692,2255,88,23198,7979,1844,10125,5710,143471,5708,115727,2246,9861,53358,2064,5717,5527,3084,5519,685,2889,7010,3690,6708,283455,5154,10048,3667	MAP3K11,JAK3,RASA2,PTK2,GRB2,RAP1A,GFRA1,FGF4,DUSP8,RASAL2,DUSP5,NF1,IL5,SPRED3,PSMC3,PPP2CB,DUSP16,CSK,MARK3,UBB,FGF17,PPP2CA,CUL3,RET,PSMB9,APBB1IP,PSMD14,SRC,PSMD8,CAMK2B,IL2RB,NEFL,PSMA3,CALM2,FGF20,PSMB10,UBA52,FRS2,MAPK3,RBX1,PAQR3,CNKSR1,PSMD7,RASAL3,DAB2IP,NRTN,KIT,PSMD5,NTRK1,GRIN2D,FGF3,NRG3,PSMC6,FGG,ARRB2,GRIN2C,AKAP9,GDNF,LAMTOR3,SPTBN1,IQGAP1,BRAF,NCAM1,SPTBN2,DLG4,PSMB2,PSMA5,MAPK1,PLCG1,DUSP6,IL5RA,PSMA4,JAK2,RASGEF1A,FGFR4,RASA4,PSMC4,GRIN2B,SHC1,RASGRF2,EGFR,HBEGF,BRAP,FGFR2,FRS3,EREG,GRIN2A,PSME3,GFRA3,PSMF1,RASGRF1,UBC,PDGFRB,GFRA2,CALM3,SPRED2,WDR83,NRG4,YWHAB,PSMA1,PPP2R5A,PSMD9,FGFR3,PSMC2,SPRED1,FGF2,FN1,FGF5,DUSP7,FGF19,PPP2R5B,SOS1,RASA1,CAMK2D,NGF,FYN,PSMB5,CRK,GFRA4,FGF9,ITGA2B,MIR5004,VWF,RAPGEF2,DUSP4,PPP2R5E,PSMD13,IL2,RASAL1,VCL,CAMK2G,ERBB4,PDGFB,SHC2,DUSP10,FGB,PSME1,IRS2,PDGFRA,ERBB3,LAT,FGF23,PSMB3,IL17RD,HGF,LAMTOR2,FGF6,RASGRP3,KL,FGF22,FGA,PSMC1,IL2RA,KITLG,FGFR1,ARRB1,ARTN,CSF2,MET,PEA15,KBTBD7,PSMB6,HRAS,PPP2R5D,PSMD12,FGF8,IL3,MAP2K2,RPS27A,PSMD1,SPTBN5,CAMK2A,PPP2R1A,KIDINS220,PTPRA,JAK1,RAP1B,KRAS,CALM1,PHB1,SPTAN1,EGF,PEBP1,RAF1,PSMA6,NRG2,FGF18,PSPN,MAP2K1,PSMB8,SPTBN4,CSF2RB,PPP5C,ANGPT1,SYNGAP1,DUSP1,FGF7,PSMB7,NRAS,PSMB11,SPTB,PSMB4,FGF10,ACTN2,PSME4,SEM1,DUSP2,RASGRP1,PSMD4,PSMA8,PSMD2,RASGRP4,FGF1,PSMD6,SHC3,ERBB2,PSMD11,PPP2R5C,NRG1,PPP2R1B,BTC,RAPGEF1,TEK,ITGB3,SPTA1,KSR2,PDGFA,RANBP9,IRS1
R-HSA-2262752	Cellular responses to stress	0.0814084738177264	-2.5082759104369	451	406	0.044941332742971	9034	10285	4001,1032,9688,5719,5693,2077,79023,817,5602,2932,8697,5691,7027,1027,112398,1871,10533,2475,2877,55054,3309,51529,2936,8345,81929,79643,3017,8368,440738,10935,8346,4217,26100,4927,3308,5718,7422,23710,6774,348995,112399,3725,8970,5606,7405,9134,7249,6767,1051,9474,57634,3320,815,53632,23043,8655,8354,9776,23112,5599,25842,5695,2878,5696,84962,7979,996,23198,4928,7157,5598,143471,5710,8341,318,3018,8367,58528,7029,5571,122706,1029,8334,57805,8897,5692,84335,5601,405,6782,55746,7266,847,7248,4361,9861,5717,5928,1031,8343,22863,10762,8360,55706,3490,4683,7314,8364,6416,55662,5702,3304,25828,723790,5562,51434,816,5714,50488,3312,3021,2353,285973,2034,2113,3576,475,50507,129401,9978,8350,94239,4194,7322,768,91782,5034,648,2882,7013,5565,8649,573,23523,23512,8357,5706,6667,5594,8290,9530,5685,8359,3091,5686,10049,57690,7323,9261,23225,3456,7321,23279,23511,128312,259217,3005,25824,60673,8370,126961,9631,3006,64344,5563,6045,493869,91582,9491,3552,3311,64121,23466,116835,8968,3281,8358,5701,83734,3313,51652,29855,10111,8339,5682,7290,11345,8352,51343,6647,6119,8335,1912,51182,29945,51422,9529,472,81631,1019,2880,51433,4688,55766,389541,53371,3009,818,22955,9531,5720,6015,92421,898,4689,28956,5700,30001,128866,3008,192670,1915,64419,9821,6118,3310,10587,1869,9973,5707,25906,6233,5694,2146,8355,65057,10370,11097,5687,57332,64682,3020,8994,7867,6648,26277,8726,8344,4790,9972,3159,10542,84557,192669,3007,8353,9532,653361,8086,7295,1017,7296,343,10808,1911,7415,57521,5708,64422,11337,30849,6117,6649,23636,56270,55004,119504,7014,126374,10919,84938,2950,10393,64223,3012,9140,2876,25913,8535,5698,4193,1026,23165,100101267,10213,1432,10670,8361,8347,1030,5713,7175,4343,25978,79400,3015,5684,6009,2114,2033,5595,5600,5699,7311,1535,23766,25994,5925,100500853,79902,84971,8363,140735,8091,8340,9448,5711,3024,55626,10728,7428,5052,9818,2056,23411,79065,1870,23135,100302237,8408,5609,5690,890,22824,1387,6195,1021,51501,26523,5564,27327,54205,8349,3326,5704,5903,6196,8900,8678,8362,7316,6923,54583,3305,7001,8365,27000,9883,8021,7531,3306,80012,8348,10197,10524,121504,8366,55062,545,57122,653604,2288,5289,84733,3569,3013,5608,6921,3337,5970,8453,257202,5715,7324,9588,11065	LMNB1,CDKN2D,NUP93,PSMD13,PSMB5,ERF,NUP37,CAMK2D,MAPK10,GSK3B,CDC23,PSMB3,TFDP1,CDKN1B,EGLN2,E2F3,ATG7,MTOR,GPX2,ATG16L1,HSPA5,ANAPC11,GSR,H2BC9,SEH1L,CHMP6,H2BC5,H4C13,MAP1LC3C,PRDX3,H2BC10,MAP3K5,WIPI2,NUP88,HSPA4,PSMD12,VEGFA,GABARAPL1,STAT3,NUP43,EGLN3,JUN,H2BC11,MAP2K3,UVRAG,CCNE2,TSC2,ST13,CEBPB,ATG5,EP400,HSP90AA1,CAMK2A,PRKAG3,TNIK,DYNLL1,H3C11,ATG13,TNRC6B,MAPK8,ASF1A,PSMB7,GPX3,PSMB8,AJUBA,SEM1,CDC27,PSME4,NUP98,TP53,MAPK7,PSMA8,PSMD4,H2BC15,NUDT2,H2BC3,H4C5,RRAGD,TFDP2,PRKAG1,PSMB11,CDKN2A,H2AC6,CCAR2,MTMR3,PSMB4,AKT1S1,MAPK9,ARNT,HSPA13,NUP133,DNAJC7,CAT,TSC1,MRE11,PSMD6,PSMD11,RBBP4,CDKN2C,H2BC7,ATG14,NUP50,H4C4,NDC1,IGFBP7,NBN,UBB,H4C3,MAP2K4,HIF1AN,PSMC3,HSPA1B,TXN2,H2AC19,PRKAA1,ANAPC7,CAMK2B,PSMD8,MINK1,HSPA8,H3-3B,FOS,ATG9B,EPAS1,ETS1,CXCL8,ATOX1,NOX4,NUP35,RBX1,H3C1,H2AZ2,MDM4,UBE2D2,CA9,CHMP7,P4HB,BMI1,GPX7,TERF1,PRKAB2,LAMTOR3,BAG1,CABIN1,SUZ12,H3C10,PSMC6,SP1,MAPK1,H3-4,BAG4,PSMA4,H4C1,HIF1A,PSMA5,DNAJB6,TNRC6C,UBE2D3,MAPKAPK2,NUP210,IFNB1,UBE2D1,NUP160,NUP188,H2BC26,HSPA12A,H1-0,PRDX5,ATG101,H4C14,H3C14,NUP155,H1-2,HIF3A,PRKAA2,RNF2,GPX8,RPS19BP1,PSMF1,IL1A,HSPA7,RRAGC,CBX6,HSPA12B,H3C7,HSBP1,H3C2,PSMC2,ATG10,HSPA9,CHMP3,UBN1,RAD50,H2BC8,PSMA1,HIRA,GABARAPL2,H3C3,FZR1,SOD1,RPA3,H2AC4,PHC2,HSPA14,ANAPC4,PRKAG2,BAG5,ATM,MAP1LC3B,CDK4,GPX5,ANAPC5,NCF2,H2AJ,LAMTOR4,NUP54,H1-5,CAMK2G,SCMH1,BAG3,PSME1,RING1,CHMP4C,CCNE1,NCF4,LAMTOR2,PSMC1,ERO1A,CHMP4B,H1-4,AGO4,EEF1A1,MTMR14,RB1CC1,RPA2,HSPA6,TXNRD2,E2F1,CCS,PSMD1,ANAPC15,RPS27A,PSMB6,EZH2,H3C8,ACD,CITED2,NUP42,PSMA6,CBX8,ANAPC1,H3-3A,LIMD1,MAPKAPK3,SOD2,TINF2,EED,H2BC6,NFKB1,NUP153,HMGA1,LAMTOR5,MAP1LC3A,AGO3,H1-3,H3C6,BAG2,NCF1,AAAS,TXN,CDK2,TXNRD1,AQP8,HSPH1,PHC1,VCP,RPTOR,PSMD2,ATG3,GABARAP,PIK3R4,RPA1,SOD3,NUP62,WDR45B,LAMTOR1,ANAPC16,TERF2,WTIP,EHMT2,ATG4C,GSTP1,ANAPC10,MLST8,H2AC8,ATG12,GPX1,POT1,CBX4,PSMB9,MDM2,CDKN1A,NUP205,POM121C,PSMD14,MAPK14,RRAGA,H4C6,H2BC4,CDKN2B,PSMD7,TPR,MOV10,CHMP2B,NOX5,H2AZ1,PSMA3,RHEB,ETS2,EP300,MAPK3,MAPK11,PSMB10,UBA52,CYBA,GABARAPL3,HIGD1A,RB1,MIR3605,NUP85,ATG4D,H4C11,DYNLL2,HMGA2,H2BC13,MAP4K4,PSMD5,H1-1,AMBRA1,PTGES3,VHL,PRDX1,NUP58,EPO,SIRT1,ATG9A,E2F2,KDM6B,MIR1281,ULK1,MAP2K7,PSMB2,CCNA2,HSPA4L,CREBBP,RPS6KA1,CDK6,HIKESHI,AGO1,PRKAB1,TNRC6A,CYCS,H2BC21,HSP90AB1,PSMC4,RANBP2,RPS6KA2,CCNA1,BECN1,H4C12,UBC,ELOB,EGLN1,HSPA1L,PRDX2,H4C8,DNAJC2,POM121,NUP214,YWHAE,HSPA2,PHC3,H2BC17,PSME3,KAT5,H4C16,H4C2,WIPI1,ATR,NUP107,H3C13,FKBP4,PIK3C3,CBX2,IL6,H2AC7,MAP2K6,ELOC,DNAJB1,RELA,CUL2,GPX6,PSMD9,UBE2E1,PRDX6,UBE2C
R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	0.0834367325335619	-2.4836666285295	44	42	0.0046491033872039	9034	10285	56267,3034,2184,6999,23498,3081,259307,123688,10157,3067,51268,8140,1738,8564,2954,125061,8942,3242,144193,5092,89874,883,131669,1428,5625,5053,4967,3620,501,138199,2639,169355,51166,6520,3176,6898,8659,130013,5860,1743,80150,85007	KYAT3,HAL,FAH,TDO2,HAAO,HGD,IL4I1,HYKK,AASS,HDC,PIPOX,SLC7A5,DLD,KMO,GSTZ1,AFMID,KYNU,HPD,AMDHD1,PCBD1,SLC25A21,KYAT1,UROC1,CRYM,PRODH,PAH,OGDH,IDO1,ALDH7A1,CARNMT1,GCDH,IDO2,AADAT,SLC3A2,HNMT,TAT,ALDH4A1,ACMSD,QDPR,DLST,ASRGL1,PHYKPL
R-HSA-1660661	Sphingolipid de novo biosynthesis	0.0834367325335619	-2.4836666285295	44	42	0.0046491033872039	9034	10285	151742,9517,222,166929,165679,8560,204219,94101,8877,130367,29956,2531,8612,8613,340485,79152,224,91012,9217,55304,5007,10558,81537,8611,253782,1455,5587,55331,29095,259230,221,10087,10715,56848,25865,79603,123099,23683,125981,8879,9218,171546	PPM1L,SPTLC2,ALDH3B2,SGMS2,SPTSSB,DEGS1,CERS3,ORMDL1,SPHK1,SGPP2,CERS2,KDSR,PLPP2,PLPP3,ACER2,FA2H,ALDH3A2,CERS5,VAPB,SPTLC3,OSBP,SPTLC1,SGPP1,PLPP1,CERS6,CSNK1G2,PRKD1,ACER3,ORMDL2,SGMS1,ALDH3B1,CERT1,CERS1,SPHK2,PRKD2,CERS4,DEGS2,PRKD3,ACER1,SGPL1,VAPA,SPTSSA
R-HSA-425393	Transport of inorganic cations/anions and amino acids/oligopeptides	0.0837474518744554	-2.47994953411946	107	99	0.0109586008412663	9034	10285	57468,6509,6541,6565,153201,55117,115019,1811,6528,6553,10723,6548,10568,6512,6521,9497,805,57084,57835,6558,6539,6575,1836,6543,115111,6560,246213,284129,6559,54407,348932,6510,389015,57030,25769,340024,1468,23382,10861,6508,81539,123041,23315,55089,6549,6533,6550,808,57282,283652,9056,6547,80024,6717,6519,9990,6568,9057,6546,26503,6520,83733,23657,10991,6557,83697,5172,117247,56301,11136,9498,8140,140679,159963,1497,54716,285195,6564,23428,8671,121260,6522,6506,8501,79751,57419,6574,6511,6505,6507,160728,51296,801,206358,6569,9187,115286,124935,6542	SLC12A5,SLC1A4,SLC7A1,SLC15A2,SLC36A2,SLC6A15,SLC26A9,SLC26A3,SLC5A5,SLC9A5,SLC12A7,SLC9A1,SLC34A2,SLC1A7,SLC4A1,SLC4A7,CALM2,SLC17A6,SLC4A5,SLC12A2,SLC6A12,SLC20A2,SLC26A2,SLC8A2,SLC26A7,SLC12A4,SLC17A8,SLC26A11,SLC12A3,SLC38A2,SLC6A18,SLC1A5,SLC9A4,SLC17A7,SLC24A2,SLC6A19,SLC25A10,AHCYL2,SLC26A1,SLC4A3,SLC38A1,SLC24A4,SLC9A8,SLC38A4,SLC9A2,SLC6A6,SLC9A3,CALM3,SLC4A10,SLC24A5,SLC7A7,SLC8A3,SLC8B1,SRI,SLC3A1,SLC12A6,SLC17A1,SLC7A6,SLC8A1,SLC17A5,SLC3A2,SLC25A18,SLC7A11,SLC38A3,SLC12A1,SLC4A9,SLC26A4,SLC16A10,SLC7A10,SLC7A9,SLC4A8,SLC7A5,SLC32A1,SLC5A12,CTNS,SLC6A20,SLC9A9,SLC15A1,SLC7A8,SLC4A4,SLC15A4,SLC4A2,SLC1A2,SLC43A1,SLC25A22,SLC24A3,SLC20A1,SLC1A6,SLC1A1,SLC1A3,SLC5A8,SLC15A3,CALM1,SLC36A1,SLC34A1,SLC24A1,SLC25A26,SLC43A2,SLC7A2
R-HSA-170968	Frs2-mediated activation	0.0843723651848498	-2.47251535771585	250	227	0.0251272968784592	9034	10285	10213,6714,5979,8452,5698,54518,3560,4747,5714,816,1847,4763,399473,3567,5702,5516,5922,3718,4296,2674,5906,2885,5747,1850,2249,9462,7314,8822,5515,80824,1445,4140,2248,10718,5706,2266,3815,4914,5711,2906,6711,8649,8826,4684,673,409,2668,10142,2905,26281,5699,7311,10818,5595,5684,805,153090,4902,152559,9978,5713,10256,64926,2904,6464,5924,10156,2264,5704,8315,1839,1956,5690,5686,6712,1742,3717,5685,221002,5594,5335,1848,3568,84292,145957,7529,5715,5525,5682,200734,808,1849,2250,9965,6654,5526,5921,2261,5701,2247,161742,2335,2903,9491,2676,10197,5923,2263,2069,10817,2675,5159,7316,25759,2244,11221,5720,3558,8437,2066,818,7414,5155,54756,8660,5156,8074,27040,5691,2065,4803,817,2534,5693,9693,1846,7450,5529,5719,3674,100847012,64096,2254,3265,8682,84078,5694,5605,6233,3562,5707,5718,5528,2253,2243,9365,27006,4254,3559,5700,2260,3082,28956,25780,2251,9048,1437,4233,408,57731,5696,1439,5536,5623,5604,2252,5695,284,8831,1843,5786,3716,3845,5908,815,51332,5518,5894,9542,8817,5687,801,5245,6709,1950,5037,2064,3084,5527,5717,5519,5708,115727,2246,53358,9861,6708,3690,5154,10048,283455,3667,2889,685,7010,5692,2255,122706,4893,6710,10125,143471,5710,23198,88,7979,1844	PSMD14,SRC,RET,CUL3,PSMB9,APBB1IP,IL2RB,NEFL,PSMD8,CAMK2B,DUSP5,NF1,SPRED3,IL5,PSMC3,PPP2CB,RASA2,JAK3,MAP3K11,GFRA1,RAP1A,GRB2,PTK2,DUSP8,FGF4,RASAL2,UBB,FGF17,PPP2CA,DUSP16,CSK,MARK3,FGF3,NRG3,PSMC6,FGG,KIT,NTRK1,PSMD5,GRIN2D,SPTBN1,LAMTOR3,IQGAP1,NCAM1,BRAF,ARRB2,GDNF,AKAP9,GRIN2C,FGF20,PSMB10,UBA52,FRS2,MAPK3,PSMA3,CALM2,DAB2IP,NRTN,PAQR3,RBX1,PSMD7,CNKSR1,RASAL3,GRIN2B,SHC1,RASGRF2,RASA4,FGFR4,PSMC4,BRAP,HBEGF,EGFR,PSMB2,PSMA5,SPTBN2,DLG4,JAK2,PSMA4,RASGEF1A,MAPK1,PLCG1,DUSP6,IL5RA,WDR83,NRG4,YWHAB,PSMD9,PPP2R5A,PSMA1,SPRED2,CALM3,DUSP7,FGF5,FGF19,SOS1,PPP2R5B,RASA1,FGFR3,PSMC2,FGF2,SPRED1,FN1,GRIN2A,PSMF1,GFRA3,PSME3,RASGRF1,FGFR2,EREG,FRS3,GFRA2,PDGFRB,UBC,SHC2,FGB,DUSP10,PSME1,IL2,RASAL1,ERBB4,CAMK2G,VCL,PDGFB,IL17RD,IRS2,PDGFRA,FGF23,LAT,PSMB3,ERBB3,NGF,CAMK2D,FYN,PSMB5,RAPGEF2,DUSP4,VWF,PPP2R5E,PSMD13,ITGA2B,MIR5004,GFRA4,FGF9,HRAS,PEA15,KBTBD7,PSMB6,MAP2K2,RPS27A,IL3,PSMD1,PSMD12,PPP2R5D,FGF8,FGA,KL,FGF22,KITLG,IL2RA,PSMC1,FGFR1,HGF,LAMTOR2,RASGRP3,FGF6,ARTN,CSF2,MET,ARRB1,SPTBN4,PSMB8,CSF2RB,PPP5C,PSPN,MAP2K1,FGF7,PSMB7,ANGPT1,SYNGAP1,DUSP1,PTPRA,JAK1,KRAS,RAP1B,CAMK2A,SPTBN5,PPP2R1A,RAF1,NRG2,FGF18,PSMA6,CALM1,PHB1,SPTAN1,EGF,PEBP1,ERBB2,NRG1,PPP2R5C,PSMD11,PPP2R1B,PSMD2,RASGRP4,FGF1,SHC3,PSMD6,SPTA1,ITGB3,PDGFA,RANBP9,KSR2,IRS1,RAPGEF1,BTC,TEK,PSMB4,FGF10,PSMB11,NRAS,SPTB,RASGRP1,PSMA8,PSMD4,PSME4,ACTN2,SEM1,DUSP2
R-HSA-1655829	Regulation of cholesterol biosynthesis by SREBP (SREBF)	0.0846530448590323	-2.46919420106724	55	52	0.00575603276510959	9034	10285	80205,8648,6667,96764,1717,5469,2222,10484,5901,2194,51141,10654,85441,22937,6721,4800,7108,4801,1387,2224,6720,1595,6604,8720,10427,3638,9632,6256,10498,9871,3157,6319,10499,79718,32,3837,3156,31,6309,6713,79071,4802,51128,4597,3422,9453,57678,4520,5465,23054,10802,4598	CHD9,NCOA1,SP1,TGS1,DHCR7,MED1,FDFT1,SEC23A,RAN,FASN,INSIG2,PMVK,HELZ2,SCAP,SREBF2,NFYA,TM7SF2,NFYB,CREBBP,FDPS,SREBF1,CYP51A1,SMARCD3,MBTPS1,SEC24B,INSIG1,SEC24C,RXRA,CARM1,SEC24D,HMGCS1,SCD,NCOA2,TBL1XR1,ACACB,KPNB1,HMGCR,ACACA,SC5D,SQLE,ELOVL6,NFYC,SAR1B,MVD,IDI1,GGPS1,GPAM,MTF1,PPARA,NCOA6,SEC24A,MVK
R-HSA-110320	Translesion Synthesis by POLH	0.0848865410228619	-2.46643972564198	19	19	0.00210316581802081	9034	10285	5982,5983,5984,7311,25898,7353,55666,5429,6117,6118,5985,7316,5981,6233,83932,7314,7415,5111,6119	RFC2,RFC3,RFC4,UBA52,RCHY1,UFD1,NPLOC4,POLH,RPA1,RPA2,RFC5,UBC,RFC1,RPS27A,SPRTN,UBB,VCP,PCNA,RPA3
R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	0.0848865410228619	-2.46643972564198	19	19	0.00210316581802081	9034	10285	1874,10498,2033,100302237,3276,7029,983,2810,891,995,5111,581,5933,5934,7027,1647,7157,6790,25946	E2F4,CARM1,EP300,MIR1281,PRMT1,TFDP2,CDK1,SFN,CCNB1,CDC25C,PCNA,BAX,RBL1,RBL2,TFDP1,GADD45A,TP53,AURKA,ZNF385A
R-HSA-5576886	Phase 4 - resting membrane potential	0.0848865410228619	-2.46643972564198	19	19	0.00210316581802081	9034	10285	54207,3761,83795,60598,50801,3759,9424,3776,3770,89822,3768,8645,3775,56659,3777,56660,338567,51305,10089	KCNK10,KCNJ4,KCNK16,KCNK15,KCNK4,KCNJ2,KCNK6,KCNK2,KCNJ14,KCNK17,KCNJ12,KCNK5,KCNK1,KCNK13,KCNK3,KCNK12,KCNK18,KCNK9,KCNK7
R-HSA-2559585	Oncogene Induced Senescence	0.0852781155835002	-2.46183741562511	32	31	0.00343148107150764	9034	10285	1031,2113,4193,27327,26523,6233,1871,1021,1869,23112,7027,1019,192670,7311,57690,5595,2114,1029,2077,7029,1870,4194,7314,4343,1032,7157,1030,5594,7316,192669,6667	CDKN2C,ETS1,MDM2,TNRC6A,AGO1,RPS27A,E2F3,CDK6,E2F1,TNRC6B,TFDP1,CDK4,AGO4,UBA52,TNRC6C,MAPK3,ETS2,CDKN2A,ERF,TFDP2,E2F2,MDM4,UBB,MOV10,CDKN2D,TP53,CDKN2B,MAPK1,UBC,AGO3,SP1
R-HSA-1169410	Antiviral mechanism by IFN-stimulated genes	0.0864705490471248	-2.44795139646219	76	71	0.0078591985831304	9034	10285	55706,9688,11097,9246,7314,7706,9818,5300,5335,25820,3716,1981,79023,3434,4599,9972,3840,23225,7334,53371,402569,3839,5903,51191,4734,23165,100101267,100500827,23279,1977,9775,23511,3838,8086,5495,7318,5610,81929,9631,6772,7316,2317,129401,3836,7175,4928,5595,4927,100847079,317649,7311,9883,9636,8672,8021,3837,79902,1974,693215,6233,23586,4600,57122,1982,3661,55746,9470,23636,7324,10762,348995	NDC1,NUP93,NUP42,UBE2L6,UBB,TRIM25,NUP58,PIN1,PLCG1,ARIH1,JAK1,EIF4G1,NUP37,IFIT1,MX1,NUP153,KPNA4,NUP210,UBE2N,NUP54,KPNA7,KPNA3,RANBP2,HERC5,NEDD4,NUP205,POM121C,MIR3614,NUP160,EIF4E,EIF4A3,NUP188,KPNA2,AAAS,PPM1B,UBA7,EIF2AK2,SEH1L,NUP155,STAT1,UBC,FLNB,NUP35,KPNA1,TPR,NUP98,MAPK3,NUP88,MIR5193,EIF4E3,UBA52,POM121,ISG15,EIF4G3,NUP214,KPNB1,NUP85,EIF4A2,MIR630,RPS27A,RIGI,MX2,NUP107,EIF4G2,IRF3,NUP133,EIF4E2,NUP62,UBE2E1,NUP50,NUP43
R-HSA-1169408	ISG15 antiviral mechanism	0.0864705490471248	-2.44795139646219	76	71	0.0078591985831304	9034	10285	3838,5495,8086,7318,5610,81929,9631,6772,7316,2317,129401,3836,7175,4928,5595,4927,100847079,317649,7311,9636,9883,8672,8021,3837,79902,1974,693215,6233,23586,57122,4600,1982,3661,9470,55746,23636,7324,10762,348995,55706,9688,11097,9246,7706,7314,9818,5335,5300,25820,3716,1981,3434,79023,4599,23225,3840,9972,7334,53371,402569,3839,51191,5903,4734,23165,100101267,100500827,23279,1977,9775,23511	KPNA2,PPM1B,AAAS,UBA7,EIF2AK2,SEH1L,NUP155,STAT1,UBC,FLNB,NUP35,KPNA1,TPR,NUP98,MAPK3,NUP88,MIR5193,EIF4E3,UBA52,ISG15,POM121,EIF4G3,NUP214,KPNB1,NUP85,EIF4A2,MIR630,RPS27A,RIGI,NUP107,MX2,EIF4G2,IRF3,EIF4E2,NUP133,NUP62,UBE2E1,NUP50,NUP43,NDC1,NUP93,NUP42,UBE2L6,TRIM25,UBB,NUP58,PLCG1,PIN1,ARIH1,JAK1,EIF4G1,IFIT1,NUP37,MX1,NUP210,KPNA4,NUP153,UBE2N,NUP54,KPNA7,KPNA3,HERC5,RANBP2,NEDD4,NUP205,POM121C,MIR3614,NUP160,EIF4E,EIF4A3,NUP188
R-HSA-425366	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.0890386732926046	-2.41868447225384	106	98	0.0108479079034758	9034	10285	861,6523,9152,29986,114134,29985,6580,29988,126969,169026,7780,6539,254428,30061,51458,9376,55117,204962,23516,9194,85413,6570,91749,57127,133418,6534,57153,200010,6566,155184,283375,26266,10864,6517,23446,6529,6515,340024,1356,6582,144195,8170,6533,284111,55676,6248,115584,6531,348932,148867,26291,23539,6538,60482,80736,100506403,6583,25800,1317,6556,56606,55356,6563,57181,84102,6571,6540,6514,5002,682,9356,6561,6526,7781,6581,81031,64116,6527,11182,4891,55867,55244,6518,64924,6530,345274,154091,6584,9123,6005,64849,116085,7779,6513,66035,146802,6536,54716	RUNX1,SLC5A1,SLC6A5,SLC39A2,SLC2A13,SLC39A3,SLC22A1,SLC2A8,SLC44A3,SLC30A8,SLC30A2,SLC6A12,SLC41A1,SLC40A1,RHCG,SLC22A8,SLC6A15,SLC44A5,SLC39A14,SLC16A7,SLC22A16,SLC18A1,MFSD4B,RHBG,EMB,SLC6A7,SLC44A2,SLC5A9,SLC16A1,SLC2A7,SLC39A5,SLC13A4,SLC22A7,SLC2A4,SLC44A1,SLC6A1,SLC2A3,SLC6A19,CP,SLC22A2,SLC2A14,SLC14A2,SLC6A6,SLC13A5,SLC30A6,RSC1A1,SLC5A11,SLC6A3,SLC6A18,SLC30A7,FGF21,SLC16A8,SLC6A11,SLC5A7,SLC44A4,LOC100506403,SLC22A4,SLC39A6,SLC31A1,SLC11A1,SLC2A9,SLC22A15,SLC14A1,SLC39A10,SLC41A2,SLC18A2,SLC6A13,SLC2A2,SLC22A18,BSG,SLC22A6,SLC13A1,SLC5A3,SLC30A3,SLC22A3,SLC2A10,SLC39A8,SLC5A4,SLC2A6,SLC11A2,SLC22A11,SLC47A1,SLC2A5,SLC30A5,SLC6A2,SLC10A6,SLC2A12,SLC22A5,SLC16A3,RHAG,SLC13A3,SLC22A12,SLC30A1,SLC2A1,SLC2A11,SLC47A2,SLC6A9,SLC6A20
R-HSA-375165	NCAM signaling for neurite out-growth	0.0902413690049877	-2.40526732063616	276	250	0.0276732344476422	9034	10285	2247,161742,2335,2261,5701,6654,5526,5921,1285,2250,1849,9965,200734,808,1286,5525,5715,5682,84292,7529,145957,7316,5159,2675,1297,2069,10817,2263,9491,2676,10197,5923,2903,1839,1956,8315,10156,2264,5704,5924,6464,2904,1848,3568,5594,3717,5685,221002,256076,6712,1742,1282,5686,5690,10142,2668,2905,409,8826,4684,673,6711,8649,2906,3815,5711,779,375790,5706,2266,783,2248,10718,64926,776,152559,9978,5713,10256,4902,153090,1298,5684,805,10818,5595,5699,26281,7311,816,5714,4747,3560,5698,54518,5979,784,8452,1284,131873,10213,6714,1299,8128,1445,4140,80824,5515,8822,785,7314,1850,2249,9462,3718,5922,4296,2674,5906,2885,5747,5702,5516,1847,4763,399473,3567,685,7010,3667,6708,3690,5154,10048,283455,2246,53358,9861,5708,775,115727,3084,5717,5527,5519,2064,7979,1844,23198,88,143471,5710,10125,6710,4893,122706,9252,5692,2255,1843,8913,284,8831,1385,2252,5695,5623,5604,5536,57731,5696,1439,1950,5621,6709,5037,801,5245,5894,8817,9542,5687,8911,815,51332,5518,3716,3845,5908,5786,2253,5528,5718,5707,8912,5605,6233,3562,1293,84078,5694,8682,3265,408,4233,9048,7903,1437,2251,25780,28956,3082,3559,4254,5700,2260,2243,9365,27006,5156,8074,27040,5691,2065,8660,54756,6900,818,2066,7414,5155,3558,8437,1463,5720,25759,11221,2244,100847012,3674,2254,64096,5719,5529,9693,7450,1846,2534,5693,817	FGF2,SPRED1,FN1,FGFR3,PSMC2,SOS1,PPP2R5B,RASA1,COL4A3,FGF5,DUSP7,FGF19,SPRED2,CALM3,COL4A4,PPP2R5A,PSMD9,PSMA1,WDR83,YWHAB,NRG4,UBC,PDGFRB,GFRA2,COL9A1,EREG,FRS3,FGFR2,PSMF1,GFRA3,PSME3,RASGRF1,GRIN2A,HBEGF,EGFR,BRAP,RASA4,FGFR4,PSMC4,RASGRF2,SHC1,GRIN2B,DUSP6,IL5RA,MAPK1,JAK2,PSMA4,RASGEF1A,COL6A5,SPTBN2,DLG4,COL4A1,PSMA5,PSMB2,AKAP9,GDNF,GRIN2C,ARRB2,IQGAP1,NCAM1,BRAF,SPTBN1,LAMTOR3,GRIN2D,KIT,PSMD5,CACNA1S,AGRN,PSMC6,FGG,CACNB2,FGF3,NRG3,RASAL3,CACNA1D,PAQR3,RBX1,PSMD7,CNKSR1,NRTN,DAB2IP,COL9A2,PSMA3,CALM2,FRS2,MAPK3,PSMB10,FGF20,UBA52,CAMK2B,PSMD8,NEFL,IL2RB,PSMB9,APBB1IP,RET,CACNB3,CUL3,COL4A2,COL6A6,PSMD14,SRC,COL9A3,ST8SIA2,CSK,MARK3,DUSP16,PPP2CA,FGF17,CACNB4,UBB,DUSP8,FGF4,RASAL2,JAK3,RASA2,MAP3K11,GFRA1,RAP1A,GRB2,PTK2,PSMC3,PPP2CB,DUSP5,NF1,SPRED3,IL5,BTC,TEK,IRS1,SPTA1,ITGB3,PDGFA,RANBP9,KSR2,FGF1,SHC3,PSMD6,PSMD2,CACNA1C,RASGRP4,NRG1,PSMD11,PPP2R5C,PPP2R1B,ERBB2,SEM1,DUSP2,PSME4,ACTN2,PSMA8,PSMD4,RASGRP1,SPTB,NRAS,PSMB11,RPS6KA5,PSMB4,FGF10,DUSP1,CACNA1G,ANGPT1,SYNGAP1,CREB1,FGF7,PSMB7,PSPN,MAP2K1,PPP5C,SPTBN4,PSMB8,CSF2RB,EGF,PRNP,SPTAN1,PEBP1,CALM1,PHB1,RAF1,FGF18,NRG2,PSMA6,CACNA1I,CAMK2A,SPTBN5,PPP2R1A,JAK1,KRAS,RAP1B,PTPRA,FGF8,PPP2R5D,PSMD12,PSMD1,CACNA1H,MAP2K2,RPS27A,IL3,COL6A3,KBTBD7,PSMB6,PEA15,HRAS,ARRB1,MET,ARTN,ST8SIA4,CSF2,FGF6,RASGRP3,LAMTOR2,HGF,IL2RA,KITLG,PSMC1,FGFR1,FGA,KL,FGF22,PDGFRA,FGF23,LAT,PSMB3,ERBB3,IRS2,IL17RD,CNTN2,CAMK2G,ERBB4,VCL,PDGFB,IL2,RASAL1,NCAN,PSME1,SHC2,DUSP10,FGB,MIR5004,ITGA2B,FGF9,GFRA4,PSMD13,PPP2R5E,RAPGEF2,VWF,DUSP4,FYN,PSMB5,CAMK2D
R-HSA-1236394	Signaling by ERBB4	0.0913989692961584	-2.3925210774329	43	41	0.00453841044941333	9034	10285	6233,51107,9611,6654,6868,2099,685,2065,10413,1839,1956,6776,145957,10718,3265,6464,4734,83737,83464,3084,2670,5295,23118,2066,7314,5241,9542,5290,6387,5664,51741,11059,1447,7316,1950,7311,3845,4893,2885,23385,2069	RPS27A,APH1A,NCOR1,SOS1,ADAM17,ESR1,BTC,ERBB3,YAP1,HBEGF,EGFR,STAT5A,NRG4,NRG3,HRAS,SHC1,NEDD4,ITCH,APH1B,NRG1,GFAP,PIK3R1,TAB2,ERBB4,UBB,PGR,NRG2,PIK3CA,CXCL12,PSEN2,WWOX,WWP1,CSN2,UBC,EGF,UBA52,KRAS,NRAS,GRB2,NCSTN,EREG
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins	0.0913989692961584	-2.3925210774329	43	41	0.00453841044941333	9034	10285	5568,2793,2788,2784,360,2786,111,5566,2790,2792,551,94235,196883,5573,358,361,2787,55970,54331,5567,4645,115,107,109,2778,114,2783,2782,5577,5575,113,59345,359,2791,8766,10681,108,5576,51764,112,22841	PRKACG,GNGT2,GNG7,GNB3,AQP3,GNG4,ADCY5,PRKACA,GNG10,GNGT1,AVP,GNG8,ADCY4,PRKAR1A,AQP1,AQP4,GNG5,GNG12,GNG2,PRKACB,MYO5B,ADCY9,ADCY1,ADCY3,GNAS,ADCY8,GNB2,GNB1,PRKAR2B,PRKAR1B,ADCY7,GNB4,AQP2,GNG11,RAB11A,GNB5,ADCY2,PRKAR2A,GNG13,ADCY6,RAB11FIP2
R-HSA-5693579	Homologous DNA Pairing and Strand Exchange	0.0913989692961584	-2.3925210774329	43	41	0.00453841044941333	9034	10285	5883,7486,6119,4683,84126,5889,80010,472,5983,1111,116028,675,10524,1763,83695,7156,5982,11073,3364,7516,5888,5884,641,10635,5892,5890,6118,5985,545,7517,9156,580,5984,672,83990,6117,79728,5810,144715,10111,4361	RAD9A,WRN,RPA3,NBN,ATRIP,RAD51C,RMI1,ATM,RFC3,CHEK1,RMI2,BRCA2,KAT5,DNA2,RHNO1,TOP3A,RFC2,TOPBP1,HUS1,XRCC2,RAD51,RAD17,BLM,RAD51AP1,RAD51D,RAD51B,RPA2,RFC5,ATR,XRCC3,EXO1,BARD1,RFC4,BRCA1,BRIP1,RPA1,PALB2,RAD1,RAD9B,RAD50,MRE11
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	0.0913989692961584	-2.3925210774329	43	41	0.00453841044941333	9034	10285	23166,1284,348,55576,3250,4035,100500842,949,78989,1281,10808,117156,9332,6678,81035,2495,335,1278,286133,259,3320,8542,1282,948,6288,2512,10525,4481,3039,100500837,3263,3043,811,3240,8685,3512,8578,338,5648,1277,213	STAB1,COL4A2,APOE,STAB2,HPR,LRP1,MIR3652,SCARB1,COLEC11,COL3A1,HSPH1,SCGB3A2,CD163,SPARC,COLEC12,FTH1,APOA1,COL1A2,SCARA5,AMBP,HSP90AA1,APOL1,COL4A1,CD36,SAA1,FTL,HYOU1,MSR1,HBA1,MIR3606,HPX,HBB,CALR,HP,MARCO,JCHAIN,SCARF1,APOB,MASP1,COL1A1,ALB
R-HSA-416476	G alpha (q) signalling events	0.0921490311292849	-2.38434810898251	192	175	0.0193712641133496	9034	10285	2847,3827,10681,7201,1902,1607,2782,10316,147,3356,747,2520,54331,8503,257313,5330,128674,148,10125,2797,222545,8477,6863,5997,886,2837,10887,5583,2776,2864,2151,5731,594857,552,7204,8111,387129,1906,2790,2767,2786,115557,10235,5581,2358,10874,26090,2769,5290,1608,2865,3060,129521,7222,551,64407,94235,2784,60675,56923,5021,5998,431704,2783,2798,64106,7225,23236,1609,347148,6866,8526,6870,6865,301,8525,2862,2693,9630,6915,3269,1606,29933,353299,6869,3357,3708,553,59345,2149,6288,3814,55970,84109,23620,146,57105,10911,2792,3710,3061,624,156,160851,6368,2796,94233,846,5724,3709,9162,2787,4923,6846,5588,57113,5020,84634,23566,11343,1241,2641,623,84539,5332,2869,2915,1907,887,5032,5031,51764,221955,185,5331,1133,2642,2867,4295,1909,4922,5296,5029,57121,7200,5295,4829,1131,5580,5028,8997,3062,57406,10287,5367,2791,10886,5737,1910,351,6375,10161,1908,2147,2150,2829,2911,183,1128,51738,8527,2788,2922,885,2793	MCHR1,KNG1,GNB5,TRHR,LPAR1,DGKB,GNB1,NMUR1,ADRA1B,HTR2A,DAGLA,GAST,GNG2,PIK3R3,UTS2B,PLCB2,PROKR2,ADRA1A,RASGRP1,GNRH2,GPRC6A,GPR65,TAC1,RGS2,CCKAR,UTS2R,PROKR1,PRKCH,GNAQ,FFAR1,F2RL2,PTGER1,NPS,AVPR1A,TRIO,GPR68,NPSR1,EDN1,GNG10,GNA11,GNG4,ARHGEF25,RASGRP2,PRKCE,FPR2,NMU,ABHD12,GNA15,PIK3CA,DGKG,FFAR3,HCRT,NMS,TRPC3,AVP,RGS18,GNG8,GNB3,PROK2,NMUR2,OXTR,RGS3,RGS21,GNB2,GNRHR,NPFFR1,TRPC6,PLCB1,DGKQ,QRFP,TAC3,DGKE,TACR3,TACR2,ANXA1,DGKZ,MLNR,GHSR,GNA14,TBXA2R,HRH1,DGKA,GPR132,RGSL1,TACR1,HTR2B,ITPR1,AVPR1B,GNB4,F2R,SAA1,KISS1,GNG12,QRFPR,NTSR2,ADRA1D,CYSLTR2,UTS2,GNGT1,ITPR3,HCRTR1,BDKRB2,GRK2,DGKH,CCL23,GNRH1,OPN4,CASR,PTAFR,ITPR2,DGKI,GNG5,NTSR1,XCL2,PRKCQ,TRPC7,OXT,KISS1R,LPAR3,MGLL,LTB4R,GCG,BDKRB1,MCHR2,PLCB4,GRK5,GRM5,EDN2,CCKBR,P2RY11,P2RY6,GNG13,DAGLB,AGTR1,PLCB3,CHRM5,GCGR,FFAR2,MLN,EDNRA,NTS,PIK3R2,P2RY2,LPAR5,TRH,PIK3R1,NMBR,CHRM3,PRKCD,P2RY1,KALRN,HCRTR2,ABHD6,RGS19,PMCH,GNG11,NPFFR2,PTGFR,EDNRB,APP,XCL1,LPAR6,EDN3,F2,F2RL1,XCR1,GRM1,AGT,CHRM1,GHRL,DGKD,GNG7,GRP,CCK,GNGT2
R-HSA-8875878	MET promotes cell motility	0.0946413295014351	-2.35766101142425	31	30	0.00332078813371707	9034	10285	284217,4233,85440,3909,1398,3675,5908,3913,5747,3912,5906,3910,2885,3082,64759,84951,3908,3911,3688,5879,100616340,3915,2889,3673,6714,100422894,3918,3914,10319,2549	LAMA1,MET,DOCK7,LAMA3,CRK,ITGA3,RAP1B,LAMB2,PTK2,LAMB1,RAP1A,LAMA4,GRB2,HGF,TNS3,TNS4,LAMA2,LAMA5,ITGB1,RAC1,MIR4758,LAMC1,RAPGEF1,ITGA2,SRC,MIR4260,LAMC2,LAMB3,LAMC3,GAB1
R-HSA-1839124	FGFR1 mutant receptor activation	0.0946413295014351	-2.35766101142425	31	30	0.00332078813371707	9034	10285	8822,399687,5290,6772,2254,9530,8805,2260,26281,2249,2251,26127,2885,7750,2250,11052,6774,6776,2247,2253,8074,9846,9208,5295,11064,613,2246,6777,1523,11160	FGF17,MYO18A,PIK3CA,STAT1,FGF9,BAG4,TRIM24,FGFR1,FGF20,FGF4,FGF6,FGFR1OP2,GRB2,ZMYM2,FGF5,CPSF6,STAT3,STAT5A,FGF2,FGF8,FGF23,GAB2,LRRFIP1,PIK3R1,CNTRL,BCR,FGF1,STAT5B,CUX1,ERLIN2
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	0.0946413295014351	-2.35766101142425	31	30	0.00332078813371707	9034	10285	53371,23225,9972,79902,55746,57122,10762,5903,100101267,23165,23636,23511,348995,23279,81929,9631,55706,9688,11097,8086,129401,3836,9818,4928,7175,4927,3837,79023,9883,8021	NUP54,NUP210,NUP153,NUP85,NUP133,NUP107,NUP50,RANBP2,POM121C,NUP205,NUP62,NUP188,NUP43,NUP160,SEH1L,NUP155,NDC1,NUP93,NUP42,AAAS,NUP35,KPNA1,NUP58,NUP98,TPR,NUP88,KPNB1,NUP37,POM121,NUP214
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	0.0946413295014351	-2.35766101142425	31	30	0.00332078813371707	9034	10285	9972,23225,79902,53371,57122,7514,55746,5903,23165,100101267,23636,10762,23279,23511,348995,55706,5901,9688,11097,8086,81929,9631,129401,9818,7175,4928,4927,9883,8021,79023	NUP153,NUP210,NUP85,NUP54,NUP107,XPO1,NUP133,RANBP2,NUP205,POM121C,NUP62,NUP50,NUP160,NUP188,NUP43,NDC1,RAN,NUP93,NUP42,AAAS,SEH1L,NUP155,NUP35,NUP58,TPR,NUP98,NUP88,POM121,NUP214,NUP37
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	0.0946413295014351	-2.35766101142425	31	30	0.00332078813371707	9034	10285	4927,79023,8021,9883,9631,81929,8086,11097,9688,55706,7175,4928,9818,129401,10762,100101267,23165,23636,5903,348995,2645,23511,23279,53371,79902,23225,9972,55746,2646,57122	NUP88,NUP37,NUP214,POM121,NUP155,SEH1L,AAAS,NUP42,NUP93,NDC1,TPR,NUP98,NUP58,NUP35,NUP50,POM121C,NUP205,NUP62,RANBP2,NUP43,GCK,NUP188,NUP160,NUP54,NUP85,NUP210,NUP153,NUP133,GCKR,NUP107
R-HSA-1296065	Inwardly rectifying K+ channels	0.0946413295014351	-2.35766101142425	31	30	0.00332078813371707	9034	10285	3762,3760,2782,2783,3763,2550,3758,6833,2792,3766,2790,2786,2784,2788,3768,3764,2793,3767,9568,3765,54331,3772,3770,3759,55970,2787,10060,3773,3761,94235	KCNJ5,KCNJ3,GNB1,GNB2,KCNJ6,GABBR1,KCNJ1,ABCC8,GNGT1,KCNJ10,GNG10,GNG4,GNB3,GNG7,KCNJ12,KCNJ8,GNGT2,KCNJ11,GABBR2,KCNJ9,GNG2,KCNJ15,KCNJ14,KCNJ2,GNG12,GNG5,ABCC9,KCNJ16,KCNJ4,GNG8
R-HSA-5339562	Uptake and actions of bacterial toxins	0.0946413295014351	-2.35766101142425	31	30	0.00332078813371707	9034	10285	5605,6844,9900,928,1839,10015,5606,22987,9899,6616,3326,118429,84168,5608,5604,808,5045,127833,6857,6843,79849,801,7296,1938,5609,2984,3320,112755,805,6416	MAP2K2,VAMP2,SV2A,CD9,HBEGF,PDCD6IP,MAP2K3,SV2C,SV2B,SNAP25,HSP90AB1,ANTXR2,ANTXR1,MAP2K6,MAP2K1,CALM3,FURIN,SYT2,SYT1,VAMP1,NHERF4,CALM1,TXNRD1,EEF2,MAP2K7,GUCY2C,HSP90AA1,STX1B,CALM2,MAP2K4
R-HSA-2682334	EPH-Ephrin signaling	0.0948467813739229	-2.35549251703115	95	88	0.00974097852557007	9034	10285	4629,2042,10095,10092,7410,10096,998,5921,6461,1212,10109,1173,83464,64283,1942,10398,1072,1969,6383,285220,28964,163,4318,1946,10451,3985,3320,2045,2047,4628,5879,2050,4313,2046,2904,284656,160,10097,8440,8997,3984,1175,5664,6386,7074,71,2049,8976,1944,9475,3791,7422,6453,5058,10552,4637,25791,8218,4067,3265,1949,60,2044,7525,103910,387,102,79784,8874,2051,10094,1948,1211,2534,23385,2043,5747,51107,1759,161,10093,1213,10627,6714,4627,1943,5062,2048	MYH11,EPHA3,ARPC1B,ARPC5,VAV2,ACTR3,CDC42,RASA1,SHB,CLTB,ARPC2,AP2M1,APH1B,ARHGEF28,EFNA1,MYL9,CFL1,EPHA2,SDC2,EPHA6,GIT1,AP2B1,MMP9,EFNA5,VAV3,LIMK2,HSP90AA1,EPHA7,EPHB1,MYH10,RAC1,EPHB4,MMP2,EPHA8,GRIN2B,EPHA10,AP2A1,ACTR2,NCK2,KALRN,LIMK1,AP2S1,PSEN2,SDCBP,TIAM1,ACTG1,EPHB3,WASL,EFNA3,ROCK2,KDR,VEGFA,ITSN1,PAK1,ARPC1A,MYL6,NGEF,CLTCL1,LYN,HRAS,EFNB3,ACTB,EPHA5,YES1,MYL12B,RHOA,ADAM10,MYH14,ARHGEF7,EPHB6,ARPC3,EFNB2,CLTA,FYN,NCSTN,EPHA4,PTK2,APH1A,DNM1,AP2A2,ARPC4,CLTC,MYL12A,SRC,MYH9,EFNA2,PAK2,EPHB2
R-HSA-418457	cGMP effects	0.0966648310434846	-2.33650563405536	18	18	0.00199247288023024	9034	10285	5153,27345,3779,5592,3778,3708,5593,10335,5152,5140,8654,5138,50940,10846,5139,5136,27094,10242	PDE1B,KCNMB4,KCNMB1,PRKG1,KCNMA1,ITPR1,PRKG2,IRAG1,PDE9A,PDE3B,PDE5A,PDE2A,PDE11A,PDE10A,PDE3A,PDE1A,KCNMB3,KCNMB2
R-HSA-1630316	Glycosaminoglycan metabolism	0.0980250727497405	-2.32253198864905	124	114	0.0126189949081249	9034	10285	4969,2799,8704,11046,6382,1463,222537,768213,337876,57214,347734,2262,26229,10861,22856,5549,23563,64131,50515,9331,11285,6482,3339,3161,375790,6487,64711,1634,6448,3038,2331,100616124,113189,27087,9060,92126,2817,10331,10402,6548,11261,2720,9957,8703,960,55790,9955,1464,2132,2683,8692,60495,79586,4060,6385,9348,9956,55454,10090,9334,55501,176,1836,126792,55576,10057,3373,9394,51000,166012,10082,11081,2131,79411,6484,4166,9435,135152,54480,3425,8702,9469,2990,9653,29940,8372,3340,10894,8534,1462,6383,411,11041,3037,4958,9953,3036,3074,26035,10675,93010,9951,9061,64132,64579,266722,79369,6483,10855,83539,51363,10678,63827,9672	OGN,GNS,B4GALT2,SLC35D2,SDC1,NCAN,HS3ST5,MIR671,CHSY3,CEMIP,SLC35B2,GPC5,B3GAT3,SLC26A1,CHSY1,PRELP,CHST5,XYLT1,CHST11,B4GALT6,B4GALT7,ST3GAL1,HSPG2,HMMR,AGRN,ST3GAL3,HS3ST6,DCN,SGSH,HAS3,FMOD,MIR4647,CHST14,B3GAT1,PAPSS2,DSEL,GPC1,B3GNT3,ST3GAL6,SLC9A1,CHP1,GLB1,HS3ST1,B4GALT3,CD44,CSGALNACT1,HS3ST3A1,CSPG4,EXT2,B4GALT1,HYAL2,HPSE2,CHPF,LUM,SDC4,NDST3,HS3ST2,CSGALNACT2,UST,B4GALT5,CHST12,ACAN,SLC26A2,B3GALT6,STAB2,ABCC5,HYAL1,HS6ST1,SLC35B3,CHST13,GPC6,KERA,EXT1,GLB1L,ST3GAL4,CHST6,CHST2,B3GAT2,CHPF2,IDUA,B4GALT4,CHST3,GUSB,HS2ST1,DSE,HYAL3,NDST1,LYVE1,CHST1,VCAN,SDC2,ARSB,B4GAT1,HAS2,OMD,HS3ST3B1,HAS1,HEXB,GLCE,CSPG5,B3GNT7,HS3ST4,PAPSS1,XYLT2,NDST4,HS6ST3,B3GNT4,ST3GAL2,HPSE,CHST9,CHST15,B3GNT2,BCAN,SDC3
R-HSA-174824	Lipoprotein metabolism	0.0995975622751781	-2.30661758983992	74	69	0.00763781270754926	9034	10285	100616211,161,1213,344,19,337,8029,335,1600,8720,348,8435,63924,160,26291,10062,3990,338328,4018,4864,163,84699,213,2,3988,1071,338,26119,5125,9619,51129,2534,345,7376,1211,29801,29116,55908,336,6646,51128,5649,81693,5567,319,23491,5568,5360,55911,5566,949,10577,3949,116519,1173,649,1175,3069,57552,341,51599,27329,5045,4023,5046,7436,5034,4547,255738	MIR4709,AP2A2,CLTC,APOC2,ABCA1,APOA4,CUBN,APOA1,DAB1,MBTPS1,APOE,SOAT2,CIDEC,AP2A1,FGF21,NR1H3,LIPC,GPIHBP1,LPA,NPC1,AP2B1,CREB3L3,ALB,A2M,LIPA,CETP,APOB,LDLRAP1,PCSK5,ABCG1,ANGPTL4,FYN,APOC3,NR1H2,CLTA,ZDHHC8,MYLIP,ANGPTL8,APOA2,SOAT1,SAR1B,RELN,AMN,PRKACB,APOF,CES3,PRKACG,PLTP,APOBR,PRKACA,SCARB1,NPC2,LDLR,APOA5,AP2M1,BMP1,AP2S1,HDLBP,NCEH1,APOC1,LSR,ANGPTL3,FURIN,LPL,PCSK6,VLDLR,P4HB,MTTP,PCSK9
R-HSA-5633007	Regulation of TP53 Activity	0.0998177661824699	-2.3044090936476	162	148	0.0163825547930042	9034	10285	6877,6875,80010,64769,639,1263,116028,2033,6880,5983,56950,7311,51230,5600,4194,79109,5458,83695,79837,6233,6794,5565,112858,6118,8445,7874,4683,10919,6119,10848,5515,7314,3622,9212,208,5516,1108,1616,6882,5562,472,11073,26013,1020,64223,51422,57459,641,2475,3066,11200,672,5984,1432,9156,80196,1457,83860,207,27154,4193,144715,133383,387893,5810,7159,3065,138474,5457,1459,5883,7316,7157,9891,10524,5563,6883,1029,7156,8851,1763,1017,5571,8396,7994,3364,54971,5985,545,91875,6881,7862,5519,6117,83990,204851,5928,5527,5371,6749,6446,7161,253260,4361,22974,5608,10111,6873,55615,54815,7486,117584,25946,5170,94241,6790,29117,5300,1107,84126,900,9219,10000,23368,1111,100302237,9099,983,11198,8626,5982,6874,133746,5518,53632,5884,890,28996,100302168,53615,8900,6879,23774,580,5564,6884,10419,5305	TAF5,TAF4B,RMI1,MEAF6,PRDM1,PLK3,RMI2,EP300,TAF9,RFC3,SMYD2,UBA52,PHF20,MAPK11,MDM4,MAPKAP1,POU4F2,RHNO1,PIP4K2C,RPS27A,STK11,PRKAB2,TP53RK,RPA2,DYRK2,USP7,NBN,EHMT2,RPA3,PPP1R13L,PPP2CA,UBB,ING2,AURKB,AKT2,PPP2CB,CHD4,DAXX,TAF11,PRKAA1,ATM,TOPBP1,L3MBTL1,CDK5,MLST8,PRKAG2,GATAD2B,BLM,MTOR,HDAC2,CHEK2,BRCA1,RFC4,MAPK14,EXO1,RNF34,CSNK2A1,TAF3,AKT1,BRPF3,MDM2,RAD9B,SETD9,KMT5A,RAD1,TP53BP2,HDAC1,TAF1L,POU4F1,CSNK2A2,RAD9A,UBC,TP53,NUAK1,KAT5,PRKAA2,TAF12,CDKN2A,TOP3A,CDK5R1,DNA2,CDK2,PRKAG1,PIP4K2B,KAT6A,HUS1,BANP,RFC5,ATR,TTC5,TAF10,BRPF1,PPP2R1B,RPA1,BRIP1,HIPK1,RBBP4,PPP2R5C,PML,SSRP1,SGK1,TP73,RICTOR,MRE11,TPX2,MAP2K6,RAD50,TAF2,PRR5,GATAD2A,WRN,RFFL,ZNF385A,PDPK1,TP53INP1,AURKA,BRD7,PIN1,CHD3,ATRIP,CCNG1,MTA2,AKT3,PPP1R13B,CHEK1,MIR1281,USP2,CDK1,SUPT16H,TP63,RFC2,TAF4,JMY,PPP2R1A,PRKAG3,RAD17,CCNA2,HIPK2,MIR1257,MBD3,CCNA1,TAF7,BRD1,BARD1,PRKAB1,TAF13,PRMT5,PIP4K2A
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	0.100044315247844	-2.30214203867866	42	40	0.00442771751162276	9034	10285	3157,6667,8648,80205,2194,10499,79718,5469,1717,2222,96764,6319,3156,32,7108,4800,4802,79071,85441,6721,31,10654,6713,6309,2224,6720,1387,4597,4801,57678,3422,6604,9453,1595,6256,4520,4598,23054,10498,5465	HMGCS1,SP1,NCOA1,CHD9,FASN,NCOA2,TBL1XR1,MED1,DHCR7,FDFT1,TGS1,SCD,HMGCR,ACACB,TM7SF2,NFYA,NFYC,ELOVL6,HELZ2,SREBF2,ACACA,PMVK,SQLE,SC5D,FDPS,SREBF1,CREBBP,MVD,NFYB,GPAM,IDI1,SMARCD3,GGPS1,CYP51A1,RXRA,MTF1,MVK,NCOA6,CARM1,PPARA
R-HSA-877300	Interferon gamma signaling	0.101002840239491	-2.29260664135319	94	87	0.0096302855877795	9034	10285	3127,3119,3661,4684,2209,10379,4940,10437,53840,9021,6737,3459,5580,8638,3120,10475,10612,3663,960,115362,3136,816,3458,5771,11074,3113,8651,818,3135,3664,2635,23321,100500827,3460,2210,117854,3105,5781,3107,3118,55128,3122,3106,817,10107,55223,2634,3665,7726,3134,388646,5371,4939,6772,6672,4502,23650,5724,163351,3394,3660,80263,3123,85363,5777,80128,3659,81603,7341,23087,115361,4261,567,2633,3717,8554,9830,7706,3133,3117,815,4938,3662,3716,5770,3383,7412	HLA-DRB5,HLA-DQB1,IRF3,NCAM1,FCGR1A,IRF9,OAS3,IFI30,TRIM34,SOCS3,TRIM21,IFNGR1,PRKCD,OASL,HLA-DQB2,TRIM38,TRIM3,IRF5,CD44,GBP5,HLA-H,CAMK2B,IFNG,PTPN2,TRIM31,HLA-DPA1,SOCS1,CAMK2G,HLA-G,IRF6,GBP3,TRIM2,MIR3614,IFNGR2,FCGR1BP,TRIM6,HLA-A,PTPN11,HLA-C,HLA-DQA2,TRIM68,HLA-DRA,HLA-B,CAMK2D,TRIM10,TRIM62,GBP2,IRF7,TRIM26,HLA-F,GBP7,PML,OAS2,STAT1,SP100,MT2A,TRIM29,PTAFR,GBP6,IRF8,IRF2,TRIM45,HLA-DRB1,TRIM5,PTPN6,TRIM46,IRF1,TRIM8,SUMO1,TRIM35,GBP4,CIITA,B2M,GBP1,JAK2,PIAS1,TRIM14,TRIM25,HLA-E,HLA-DQA1,CAMK2A,OAS1,IRF4,JAK1,PTPN1,ICAM1,VCAM1
R-HSA-199977	ER to Golgi Anterograde Transport	0.101656431288986	-2.28615647195703	133	122	0.0135045384104494	9034	10285	10652,378,83548,23256,1315,6710,10282,10113,22796,9871,1783,10342,1778,9117,8774,23243,10802,22820,26984,64689,1781,90411,377,79090,10972,6708,5861,2153,9527,51128,51693,54732,79748,27095,51332,26286,11258,6712,55738,6811,122553,84364,1075,10959,7039,11196,22818,84342,1453,6709,26958,57731,10175,55014,10427,966,84516,5537,51143,25839,11014,55291,8655,381,51164,83696,1639,11316,372,51014,374,1780,10466,375056,23423,1604,100313843,6396,2801,1522,81876,51272,8729,11070,9570,7109,375,8615,91949,140735,6711,10960,11015,89866,3630,58485,10671,287,9554,254263,22872,1294,57511,5265,10484,2890,51226,9382,288,149111,4905,4253,9276,128637,10945,2348,9632,286,2804,63908,3998,10540	YKT6,ARF4,COG3,SCFD1,COPB1,SPTB,BET1,PREB,COG2,SEC24D,DYNC1LI2,TFG,DYNC1H1,SEC22C,NAPG,ANKRD28,SEC24A,COPG1,SEC22A,GORASP1,DYNC1I2,MCFD2,ARF3,TRAPPC6A,TMED10,SPTA1,RAB1A,F5,GOSR1,SAR1B,TRAPPC2L,TMED9,LMAN1L,TRAPPC3,SPTBN5,ARFGAP3,DCTN3,SPTBN2,ARFGAP1,STX5,TRAPPC6B,ARFGAP2,CTSC,TMED2,TGFA,SEC23IP,COPZ1,COG8,CSNK1D,SPTAN1,COPG2,SPTBN4,CNIH1,STX17,SEC24B,CD59,DCTN5,PPP6C,DYNC1LI1,COG4,KDELR2,PPP6R3,DYNLL1,ARF5,DCTN4,TRAPPC9,DCTN1,COPE,ARCN1,TMED7,AREG,DYNC1I1,COG5,MIA3,TMED3,CD55,MIR711,SEC13,GOLGA2,CTSZ,RAB1B,BET1L,GBF1,TMEM115,GOSR2,TRAPPC10,ARF1,USO1,COG7,DYNLL2,SPTBN1,LMAN2,KDELR3,SEC16B,INS,TRAPPC1,DCTN6,ANK2,SEC22B,CNIH2,SEC31A,COL7A1,COG6,SERPINA1,SEC23A,GRIA1,COPZ2,COG1,ANK3,CNIH3,NSF,MIA2,COPB2,TBC1D20,KDELR1,FOLR1,SEC24C,ANK1,GOLGB1,NAPB,LMAN1,DCTN2
R-HSA-420092	Glucagon-type ligand receptors	0.104959295738022	-2.25418266362192	30	29	0.0032100951959265	9034	10285	2778,2783,2696,116,2782,59345,2740,2791,2642,2691,10681,2695,51764,6344,2793,2784,2788,2641,2692,2786,2790,2792,94235,9340,55970,2787,54331,117,6343	GNAS,GNB2,GIPR,ADCYAP1,GNB1,GNB4,GLP1R,GNG11,GCGR,GHRH,GNB5,GIP,GNG13,SCTR,GNGT2,GNB3,GNG7,GCG,GHRHR,GNG4,GNG10,GNGT1,GNG8,GLP2R,GNG12,GNG5,GNG2,ADCYAP1R1,SCT
R-HSA-5654696	Downstream signaling of activated FGFR2	0.104959295738022	-2.25418266362192	30	29	0.0032100951959265	9034	10285	2246,2549,5295,6464,3265,2248,2247,2253,8074,6654,2252,2250,2249,10817,2251,2263,2885,4893,10818,3845,26281,2255,27006,5781,2254,5335,8822,5290,8817	FGF1,GAB1,PIK3R1,SHC1,HRAS,FGF3,FGF2,FGF8,FGF23,SOS1,FGF7,FGF5,FGF4,FRS3,FGF6,FGFR2,GRB2,NRAS,FRS2,KRAS,FGF20,FGF10,FGF22,PTPN11,FGF9,PLCG1,FGF17,PIK3CA,FGF18
R-HSA-2132295	MHC class II antigen presentation	0.106636226343022	-2.2383319906187	103	95	0.0105158290901041	9034	10285	147700,3127,26052,3119,29127,6396,10437,1785,81930,140735,130340,375,1780,1175,3798,1513,51164,1639,83547,3831,10120,7879,3120,3113,1759,3799,10540,161,1213,1514,972,1520,64837,56992,9632,10112,26153,1519,3118,10121,10484,3902,3111,11004,10671,3122,1211,22872,9493,51128,3112,1515,1173,10802,1781,8722,3109,1508,1510,821,164,3796,1783,9871,1778,1062,6456,89953,3123,22920,3797,3835,114876,10053,162,51143,84516,3832,8655,84643,10427,160,1512,8907,285643,1075,163,5641,1509,3108,1174,11127,6712,11258,3117	KLC3,HLA-DRB5,DNM3,HLA-DQB1,RACGAP1,SEC13,IFI30,DNM2,KIF18A,DYNLL2,AP1S3,ARF1,DYNC1I1,AP2S1,KIF5A,CTSK,DCTN4,DCTN1,RILP,KLC1,ACTR1B,RAB7A,HLA-DQB2,HLA-DPA1,DNM1,KIF5B,DCTN2,AP2A2,CLTC,CTSL,CD74,CTSS,KLC2,KIF15,SEC24C,KIF20A,KIF26A,CTSO,HLA-DQA2,ACTR1A,SEC23A,LAG3,HLA-DOA,KIF2C,DCTN6,HLA-DRA,CLTA,SEC31A,KIF23,SAR1B,HLA-DOB,CTSV,AP2M1,SEC24A,DYNC1I2,CTSF,HLA-DMB,CTSB,CTSE,CANX,AP1G1,KIF2A,DYNC1LI2,SEC24D,DYNC1H1,CENPE,SH3GL2,KLC4,HLA-DRB1,KIFAP3,KIF3C,KIF22,OSBPL1A,AP1M2,AP1B1,DYNC1LI1,DCTN5,KIF11,DYNLL1,KIF2B,SEC24B,AP2A1,CTSH,AP1M1,KIF4B,CTSC,AP2B1,LGMN,CTSD,HLA-DMA,AP1S1,KIF3A,SPTBN2,DCTN3,HLA-DQA1
R-HSA-2980766	Nuclear Envelope Breakdown	0.108141880214176	-2.22431120832742	52	49	0.00542395395173788	9034	10285	91754,4001,9818,23592,11097,55706,8815,9688,10783,983,64900,79023,221496,5579,23175,9972,23225,53371,891,23279,23511,23165,100101267,9663,5903,140609,7443,4000,7175,5578,4928,255919,129401,8086,5347,81929,9631,9883,8021,4927,7444,57122,9133,55746,7112,79902,348995,23636,10762	NEK9,LMNB1,NUP58,LEMD3,NUP42,NDC1,BANF1,NUP93,NEK6,CDK1,LPIN3,NUP37,LEMD2,PRKCB,LPIN1,NUP153,NUP210,NUP54,CCNB1,NUP160,NUP188,NUP205,POM121C,LPIN2,RANBP2,NEK7,VRK1,LMNA,TPR,PRKCA,NUP98,CNEP1R1,NUP35,AAAS,PLK1,SEH1L,NUP155,POM121,NUP214,NUP88,VRK2,NUP107,CCNB2,NUP133,TMPO,NUP85,NUP43,NUP62,NUP50
R-HSA-445717	Aquaporin-mediated transport	0.108141880214176	-2.22431120832742	52	49	0.00542395395173788	9034	10285	10681,89872,363,359,59345,8766,51764,22841,108,113,2782,361,358,94235,551,4645,54331,107,109,55970,360,2784,375318,111,2792,2791,366,112,5576,364,362,2783,114,2778,282679,5577,5575,196883,5573,343,5567,115,2787,2788,2793,5568,5566,2790,2786	GNB5,AQP10,AQP6,AQP2,GNB4,RAB11A,GNG13,RAB11FIP2,ADCY2,ADCY7,GNB1,AQP4,AQP1,GNG8,AVP,MYO5B,GNG2,ADCY1,ADCY3,GNG12,AQP3,GNB3,AQP12A,ADCY5,GNGT1,GNG11,AQP9,ADCY6,PRKAR2A,AQP7,AQP5,GNB2,ADCY8,GNAS,AQP11,PRKAR2B,PRKAR1B,ADCY4,PRKAR1A,AQP8,PRKACB,ADCY9,GNG5,GNG7,GNGT2,PRKACG,PRKACA,GNG10,GNG4
R-HSA-5620924	Intraflagellar transport	0.109420347285941	-2.21255841647158	41	39	0.00431702457383219	9034	10285	22920,3797,11127,51626,57539,23059,6991,8100,112752,57576,56912,200132,57560,64792,9321,28981,79659,11020,83658,26160,80173,9742,89891,51098,140735,83657,57728,55081,79989,55112,92104,3842,255758,26146,55764,79809,8655,150737,51668	KIFAP3,KIF3C,KIF3A,DYNC2LI1,WDR35,CLUAP1,DYNLT2,IFT88,IFT43,KIF17,IFT46,DYNLT5,IFT80,IFT22,TRIP11,IFT81,DYNC2H1,IFT27,DYNLRB1,IFT172,IFT74,IFT140,DYNC2I2,IFT52,DYNLL2,DYNLRB2,WDR19,IFT57,IFT56,DYNC2I1,IFT70A,TNPO1,DYNLT2B,TRAF3IP1,IFT122,TTC21B,DYNLL1,IFT70B,IFT25
R-HSA-5656121	Translesion synthesis by POLI	0.110075910517679	-2.20658505558094	17	17	0.00188177994243967	9034	10285	5982,5980,5983,7311,5984,11201,6117,10459,51455,6118,5985,7316,7314,5981,6233,5111,6119	RFC2,REV3L,RFC3,UBA52,RFC4,POLI,RPA1,MAD2L2,REV1,RPA2,RFC5,UBC,UBB,RFC1,RPS27A,PCNA,RPA3
R-HSA-5655862	Translesion synthesis by POLK	0.110075910517679	-2.20658505558094	17	17	0.00188177994243967	9034	10285	5111,7314,6233,5981,6119,6118,51455,7316,5985,5983,7311,5984,51426,10459,6117,5982,5980	PCNA,UBB,RPS27A,RFC1,RPA3,RPA2,REV1,UBC,RFC5,RFC3,UBA52,RFC4,POLK,MAD2L2,RPA1,RFC2,REV3L
R-HSA-432142	Platelet sensitization by LDL	0.110075910517679	-2.20658505558094	17	17	0.00188177994243967	9034	10285	1432,7804,5527,5321,5516,5525,5519,5518,2268,5175,5529,5526,5515,338,5777,5528,5781	MAPK14,LRP8,PPP2R5C,PLA2G4A,PPP2CB,PPP2R5A,PPP2R1B,PPP2R1A,FGR,PECAM1,PPP2R5E,PPP2R5B,PPP2CA,APOB,PTPN6,PPP2R5D,PTPN11
R-HSA-111931	PKA-mediated phosphorylation of CREB	0.110075910517679	-2.20658505558094	17	17	0.00188177994243967	9034	10285	5568,114,5577,5575,111,5566,113,1385,5573,196883,108,5576,5567,115,109,112,107	PRKACG,ADCY8,PRKAR2B,PRKAR1B,ADCY5,PRKACA,ADCY7,CREB1,PRKAR1A,ADCY4,ADCY2,PRKAR2A,PRKACB,ADCY9,ADCY3,ADCY6,ADCY1
R-HSA-622312	Inflammasomes	0.110075910517679	-2.20658505558094	17	17	0.00188177994243967	9034	10285	29108,3326,10628,351,5027,596,10910,58484,114548,4210,22861,9051,7295,834,24145,9447,598	PYCARD,HSP90AB1,TXNIP,APP,P2RX7,BCL2,SUGT1,NLRC4,NLRP3,MEFV,NLRP1,PSTPIP1,TXN,CASP1,PANX1,AIM2,BCL2L1
R-HSA-5625900	RHO GTPases activate CIT	0.110075910517679	-2.20658505558094	17	17	0.00188177994243967	9034	10285	4627,10398,1742,100302274,388,11113,4628,9055,389,103910,387,4629,79784,4637,1027,5879,9928	MYH9,MYL9,DLG4,MIR1178,RHOB,CIT,MYH10,PRC1,RHOC,MYL12B,RHOA,MYH11,MYH14,MYL6,CDKN1B,RAC1,KIF14
R-HSA-164378	PKA activation in glucagon signalling	0.110075910517679	-2.20658505558094	17	17	0.00188177994243967	9034	10285	113,111,5566,5575,5577,2778,114,5568,115,109,112,107,5567,108,5576,196883,5573	ADCY7,ADCY5,PRKACA,PRKAR1B,PRKAR2B,GNAS,ADCY8,PRKACG,ADCY9,ADCY3,ADCY6,ADCY1,PRKACB,ADCY2,PRKAR2A,ADCY4,PRKAR1A
R-HSA-5628897	TP53 Regulates Metabolic Genes	0.114862229962532	-2.16402186912072	82	76	0.00841266327208324	9034	10285	50484,7529,285521,1337,57521,9377,7248,8649,5565,7533,143686,51241,27165,64121,6009,192670,6341,7296,57103,28956,2810,58528,5563,7531,10128,1329,5571,4343,7001,7295,2936,10670,192669,7157,25824,1345,54541,1353,207,54205,2877,27327,10542,5564,1350,26523,7532,10971,2475,2744,389541,83667,1327,27161,23112,84987,208,116228,9167,5562,2821,57690,27244,4697,8626,51422,53632,5728,64223,1351,1340,5052,7249,7534,55004,10000	RRM2B,YWHAB,COX18,COX6A1,RPTOR,COX5A,TSC1,LAMTOR3,PRKAB2,YWHAH,SESN3,COX16,GLS2,RRAGC,RHEB,AGO4,SCO1,TXNRD1,TIGAR,LAMTOR2,SFN,RRAGD,PRKAA2,YWHAE,LRPPRC,COX5B,PRKAG1,MOV10,PRDX2,TXN,GSR,RRAGA,AGO3,TP53,PRDX5,COX6C,DDIT4,COX11,AKT1,CYCS,GPX2,TNRC6A,LAMTOR5,PRKAB1,COX7C,AGO1,YWHAG,YWHAQ,MTOR,GLS,LAMTOR4,SESN2,COX4I1,AGO2,TNRC6B,COX14,AKT2,COX20,COX7A2L,PRKAA1,GPI,TNRC6C,SESN1,NDUFA4,TP63,PRKAG2,PRKAG3,PTEN,MLST8,COX8A,COX6B1,PRDX1,TSC2,YWHAZ,LAMTOR1,AKT3
R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	0.114862229962532	-2.16402186912072	82	76	0.00841266327208324	9034	10285	23303,3798,1062,55614,23095,221458,23423,3796,3835,378,124602,372,51014,1315,60561,22920,381,89953,3831,10749,3797,11316,11015,9585,547,147700,10972,23046,5861,51594,3833,9493,8729,375,377,81930,29127,81876,8774,22820,10959,285643,53407,22818,51226,55850,26153,113220,3834,84364,26286,55083,55738,54732,11004,11127,9554,3832,11014,64147,55582,6836,146909,63908,3799,55605,56992,9276,9183,64837,10945,10112,26958,662,84643,4905	KIF13B,KIF5A,CENPE,KIF16B,KIF1B,KIF6,TMED3,KIF2A,KIF22,ARF4,KIF19,ARCN1,TMED7,COPB1,RINT1,KIFAP3,ARF5,KLC4,KLC1,KIF1C,KIF3C,COPE,KDELR3,KIF20B,KIF1A,KLC3,TMED10,KIF21B,RAB1A,NBAS,KIFC1,KIF23,GBF1,ARF1,ARF3,KIF18A,RACGAP1,RAB1B,NAPG,COPG1,TMED2,KIF4B,STX18,COPZ1,COPZ2,USE1,KIF26A,KIF12,KIF25,ARFGAP2,ARFGAP3,KIF26B,ARFGAP1,TMED9,KIF2C,KIF3A,SEC22B,KIF11,KDELR2,KIF9,KIF27,SURF4,KIF18B,NAPB,KIF5B,KIF21A,KIF15,COPB2,ZW10,KLC2,KDELR1,KIF20A,COPG2,BNIP1,KIF2B,NSF
R-HSA-5218920	VEGFR2 mediated vascular permeability	0.11631658187709	-2.15143965114201	29	28	0.00309940225813593	9034	10285	801,10000,4846,5170,1499,7409,55615,3320,805,64223,79109,10451,57761,7410,1500,208,5879,3728,2475,5058,5062,808,207,253260,117145,857,1495,1003	CALM1,AKT3,NOS3,PDPK1,CTNNB1,VAV1,PRR5,HSP90AA1,CALM2,MLST8,MAPKAP1,VAV3,TRIB3,VAV2,CTNND1,AKT2,RAC1,JUP,MTOR,PAK1,PAK2,CALM3,AKT1,RICTOR,THEM4,CAV1,CTNNA1,CDH5
R-HSA-390918	Peroxisomal lipid metabolism	0.11631658187709	-2.15143965114201	29	28	0.00309940225813593	9034	10285	3295,224,8309,79777,10478,54677,283927,8443,8540,8310,30,11001,10005,23417,5264,10455,3417,51,6342,51179,55289,55825,390916,23600,91452,1384,26061,1962	HSD17B4,ALDH3A2,ACOX2,ACBD4,SLC25A17,CROT,NUDT7,GNPAT,AGPS,ACOX3,ACAA1,SLC27A2,ACOT8,MLYCD,PHYH,ECI2,IDH1,ACOX1,SCP2,HAO2,ACOXL,PECR,NUDT19,AMACR,ACBD5,CRAT,HACL1,EHHADH
R-HSA-2032785	YAP1- and WWTR1 (TAZ)-stimulated gene expression	0.11631658187709	-2.15143965114201	29	28	0.00309940225813593	9034	10285	85441,7004,1490,5469,8463,96764,860,79718,10499,7005,80205,8648,25937,23054,10498,5465,6910,7003,2626,204851,4878,6256,8850,1482,6604,1387,10413,28996	HELZ2,TEAD4,CCN2,MED1,TEAD2,TGS1,RUNX2,TBL1XR1,NCOA2,TEAD3,CHD9,NCOA1,WWTR1,NCOA6,CARM1,PPARA,TBX5,TEAD1,GATA4,HIPK1,NPPA,RXRA,KAT2B,NKX2-5,SMARCD3,CREBBP,YAP1,HIPK2
R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange	0.119576283302633	-2.12380075727489	40	38	0.00420633163604162	9034	10285	84126,80010,5889,5883,6119,4683,7486,1763,83695,7156,11073,5982,5983,472,675,10524,1111,116028,5892,6118,5890,545,5985,5884,7516,3364,5888,641,5810,4361,144715,10111,9156,580,5984,672,83990,6117	ATRIP,RMI1,RAD51C,RAD9A,RPA3,NBN,WRN,DNA2,RHNO1,TOP3A,TOPBP1,RFC2,RFC3,ATM,BRCA2,KAT5,CHEK1,RMI2,RAD51D,RPA2,RAD51B,ATR,RFC5,RAD17,XRCC2,HUS1,RAD51,BLM,RAD1,MRE11,RAD9B,RAD50,EXO1,BARD1,RFC4,BRCA1,BRIP1,RPA1
R-HSA-5654741	Signaling by FGFR3	0.119576283302633	-2.12380075727489	40	38	0.00420633163604162	9034	10285	5781,7316,2254,5594,5335,8822,867,5515,8817,5290,7314,10817,2249,5518,4893,2885,10818,5595,3845,5516,26281,7311,2247,2253,8074,2261,6654,673,2250,6233,2246,2549,2591,10253,5295,6464,3265,6714	PTPN11,UBC,FGF9,MAPK1,PLCG1,FGF17,CBL,PPP2CA,FGF18,PIK3CA,UBB,FRS3,FGF4,PPP2R1A,NRAS,GRB2,FRS2,MAPK3,KRAS,PPP2CB,FGF20,UBA52,FGF2,FGF8,FGF23,FGFR3,SOS1,BRAF,FGF5,RPS27A,FGF1,GAB1,GALNT3,SPRY2,PIK3R1,SHC1,HRAS,SRC
R-HSA-168276	NS1 Mediated Effects on Host Pathways	0.119576283302633	-2.12380075727489	40	38	0.00420633163604162	9034	10285	4928,7175,129401,3836,9818,8086,11097,3838,55706,9688,81929,9631,5610,9883,9636,8021,3837,79023,4927,57122,10898,55746,3839,79902,9972,3840,23225,8106,53371,402569,23279,348995,23511,100101267,23165,23636,5903,10762	NUP98,TPR,NUP35,KPNA1,NUP58,AAAS,NUP42,KPNA2,NDC1,NUP93,SEH1L,NUP155,EIF2AK2,POM121,ISG15,NUP214,KPNB1,NUP37,NUP88,NUP107,CPSF4,NUP133,KPNA3,NUP85,NUP153,KPNA4,NUP210,PABPN1,NUP54,KPNA7,NUP160,NUP43,NUP188,POM121C,NUP205,NUP62,RANBP2,NUP50
R-HSA-421270	Cell-cell junction organization	0.120986622611095	-2.11207529643036	61	57	0.00630949745406243	9034	10285	1009,1002,1365,1495,1366,64398,149461,1012,5584,84552,9069,7122,84612,5010,26285,5818,1004,5817,4301,253559,57863,25945,5819,1000,999,9076,50848,1003,9080,3728,56288,1010,49861,53842,9071,10207,23562,1013,1364,283,137075,1015,1006,51208,9073,1500,1008,81607,1005,1016,1007,24146,10686,1499,23705,64403,1001	CDH11,CDH4,CLDN3,CTNNA1,CLDN7,PALS1,CLDN19,CDH13,PRKCI,PARD6G,CLDN12,CLDN5,PARD6B,CLDN11,CLDN17,NECTIN1,CDH6,PVR,AFDN,CADM2,CADM3,NECTIN3,NECTIN2,CDH2,CDH1,CLDN1,F11R,CDH5,CLDN9,JUP,PARD3,CDH12,CLDN20,CLDN22,CLDN10,PATJ,CLDN14,CDH15,CLDN4,ANG,CLDN23,CDH17,CDH8,CLDN18,CLDN8,CTNND1,CDH10,NECTIN4,CDH7,CDH18,CDH9,CLDN15,CLDN16,CTNNB1,CADM1,CDH24,CDH3
R-HSA-2980736	Peptide hormone metabolism	0.121517214694094	-2.10769934151282	91	84	0.00929820677440779	9034	10285	23478,2864,30001,149371,1803,93659,55763,2999,1082,43,3800,23265,5443,3479,169026,2695,290,1499,7349,56605,3623,3798,3952,3972,1369,51738,183,2641,2626,1522,3625,2922,1511,1359,6934,4644,2688,90701,84909,60559,11336,5873,3670,3626,9789,94115,5122,619373,25924,5080,9314,1215,3630,10640,1509,338557,4311,54536,2488,1363,83729,64924,55676,51764,5126,1395,7941,1360,1361,1045,1636,148867,7252,60412,2784,5972,3799,346562,2028,55770,1081,6844,590,3624	SEC11A,FFAR1,ERO1A,EXOC8,DPP4,CGB5,EXOC1,GZMH,CGB3,ACHE,KIF5C,EXOC7,POMC,IGF1,SLC30A8,GIP,ANPEP,CTNNB1,UCN,ERO1B,INHA,KIF5A,LEP,LHB,CPN1,GHRL,AGT,GCG,GATA4,CTSZ,INHBB,GRP,CTSG,CPA3,TCF7L2,MYO5A,GH1,SEC11C,AOPEP,SPCS3,EXOC3,RAB27A,ISL1,INHBC,SPCS2,CGB8,PCSK1,MBOAT4,MYRIP,PAX6,KLF4,CMA1,INS,EXOC5,CTSD,FFAR4,MME,EXOC6,FSHB,CPE,INHBE,SLC30A5,SLC30A6,GNG13,PCSK2,CRHR2,PLA2G7,CPB1,CPB2,CDX2,ACE,SLC30A7,TSHB,EXOC4,GNB3,REN,KIF5B,GNAT3,ENPEP,EXOC2,CGA,VAMP2,BCHE,INHBA
R-HSA-5693532	DNA Double-Strand Break Repair	0.122887279674439	-2.09648776919528	167	152	0.0168253265441665	9034	10285	9682,545,5985,5888,7516,3364,5427,5893,4361,56655,165918,10111,8467,7515,8360,7517,6117,83990,8343,8339,7157,84464,8914,322,7316,5883,9025,8367,8365,3018,8370,8341,6047,7156,1763,2139,1017,5591,54107,348654,7329,121504,8366,51567,10524,51588,8348,10714,890,3980,5884,2237,7334,5599,8349,23514,7341,8362,580,8900,128312,2138,5536,8290,84126,63967,2547,5889,10038,8359,7486,5982,23030,29086,51548,8344,1111,6118,5890,10635,2072,197342,7336,7518,27434,5981,6233,5111,8314,27343,8340,8363,8970,8345,9577,8347,80010,51750,8361,3838,83695,8346,8368,3017,10721,5983,7311,6613,146956,7158,2140,116028,5531,5892,2070,11200,151987,25,9656,84142,2067,641,142,5810,8924,79728,5424,64421,55775,51720,54962,144715,7520,5984,9156,22976,672,79840,55183,7314,4683,6119,7468,9031,57804,11073,8364,3981,51426,472,5429,675	KDM4A,ATR,RFC5,RAD51,XRCC2,HUS1,POLE2,RAD52,MRE11,POLE4,RNF168,RAD50,SMARCA5,XRCC1,H4C4,XRCC3,RPA1,BRIP1,H2BC7,H2BC8,TP53,SLX4,TIMELESS,APBB1,UBC,RAD9A,RNF8,H4C5,H4C8,H2BC3,H4C14,H2BC15,RNF4,TOP3A,DNA2,EYA2,CDK2,PRKDC,POLE3,GEN1,UBE2I,H4C16,H4C2,TDP2,KAT5,PIAS4,H2BC17,POLD3,CCNA2,LIG3,RAD17,FEN1,UBE2N,MAPK8,H2BC21,SPIDR,SUMO1,H4C12,BARD1,CCNA1,H2BC26,EYA1,PPP5C,H3-4,ATRIP,CLSPN,XRCC6,RAD51C,PARP2,H4C1,WRN,RFC2,KDM4B,BABAM1,SIRT6,H2BC6,CHEK1,RPA2,RAD51B,RAD51AP1,ERCC4,EME2,UBE2V2,XRCC4,POLM,RFC1,RPS27A,PCNA,BAP1,POLL,H2BC13,H4C11,H2BC11,H2BC9,BABAM2,H2BC4,RMI1,RTEL1,H4C6,KPNA2,RHNO1,H2BC10,H4C13,H2BC5,POLQ,RFC3,UBA52,SUMO2,EME1,TP53BP1,EYA3,RMI2,PPP4C,RAD51D,EYA4,CHEK2,PPP4R2,ABL1,MDC1,ABRAXAS1,ERCC1,BLM,PARP1,RAD1,HERC2,PALB2,POLD1,DCLRE1C,TDP1,UIMC1,TIPIN,RAD9B,XRCC5,RFC4,EXO1,PAXIP1,BRCA1,NHEJ1,RIF1,UBB,NBN,RPA3,NSD2,BAZ1B,POLD4,TOPBP1,H4C3,LIG4,POLK,ATM,POLH,BRCA2
R-HSA-2990846	SUMOylation	0.124587353841611	-2.08274817182772	110	101	0.0111799867168475	9034	10285	10762,6117,23636,79677,5371,7150,3190,165918,7508,84733,1911,10054,5893,55746,9063,57122,51602,80012,51588,1029,6045,286053,7329,9883,8021,6996,9631,29843,25950,8086,4928,7157,6672,7155,5903,23511,23279,7341,7021,23225,9972,6612,57332,332,51564,8554,11097,10274,7486,6670,9818,6790,59343,3619,7153,348995,5885,5111,79902,100500853,7518,648,6613,7158,3183,4927,407043,7022,197370,493861,81929,83746,7175,129401,205564,672,100101267,23165,6015,142,8924,22955,4286,4193,53371,10055,641,8535,54780,9656,7703,9126,56160,7020,79023,1912,55706,9688,5905,9212,23137	NUP50,RPA1,NUP62,SMC6,PML,TOP1,HNRNPK,RNF168,XPC,CBX2,PHC1,UBA2,RAD52,NUP133,PIAS2,NUP107,NOP58,PHC3,PIAS4,CDKN2A,RNF2,NSMCE2,UBE2I,POM121,NUP214,TDG,NUP155,SENP1,RWDD3,AAAS,NUP98,TP53,SP100,TOP2B,RANBP2,NUP188,NUP160,SUMO1,TFAP2B,NUP210,NUP153,SUMO3,CBX8,BIRC5,HDAC7,PIAS1,NUP42,STAG1,WRN,SP3,NUP58,AURKA,SENP2,INCENP,TOP2A,NUP43,RAD21,PCNA,NUP85,MIR3605,XRCC4,BMI1,SUMO2,TP53BP1,HNRNPC,NUP88,MIR7-1,TFAP2C,NSMCE1,EID3,SEH1L,L3MBTL2,TPR,NUP35,SENP5,BRCA1,POM121C,NUP205,RING1,PARP1,HERC2,SCMH1,MITF,MDM2,NUP54,SAE1,BLM,CBX4,NSMCE4A,MDC1,PCGF2,SMC3,NSMCE3,TFAP2A,NUP37,PHC2,NDC1,NUP93,RANGAP1,AURKB,SMC5
R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	23523,3006,3009,3159,8091,3024,7290,3008,5925,7157,4001,3007,3005,25842,57634,29855	CABIN1,H1-2,H1-5,HMGA1,HMGA2,H1-1,HIRA,H1-4,RB1,TP53,LMNB1,H1-3,H1-0,ASF1A,EP400,UBN1
R-HSA-5654219	Phospholipase C-mediated cascade: FGFR1	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	2251,2246,2249,2260,2255,27006,9365,26281,2248,2254,2253,8074,2247,5335,8822,2250	FGF6,FGF1,FGF4,FGFR1,FGF10,FGF22,KL,FGF20,FGF3,FGF9,FGF8,FGF23,FGF2,PLCG1,FGF17,FGF5
R-HSA-1433559	Regulation of KIT signaling	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	2534,3815,3932,10603,2885,4254,9306,4067,6714,5578,867,5777,6654,10019,7525,8651	FYN,KIT,LCK,SH2B2,GRB2,KITLG,SOCS6,LYN,SRC,PRKCA,CBL,PTPN6,SOS1,SH2B3,YES1,SOCS1
R-HSA-1963640	GRB2 events in ERBB2 signaling	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	2066,2069,4893,2885,3084,3845,3265,2064,145957,10718,1950,1956,1839,685,6654,9542	ERBB4,EREG,NRAS,GRB2,NRG1,KRAS,HRAS,ERBB2,NRG4,NRG3,EGF,EGFR,HBEGF,BTC,SOS1,NRG2
R-HSA-5637810	Constitutive Signaling by EGFRvIII	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	3320,4893,2885,2549,3265,5295,11140,6464,3845,100302213,5335,1956,1950,867,6654,5290	HSP90AA1,NRAS,GRB2,GAB1,HRAS,PIK3R1,CDC37,SHC1,KRAS,MIR1181,PLCG1,EGFR,EGF,CBL,SOS1,PIK3CA
R-HSA-163615	PKA activation	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	114,5568,5575,5577,113,5566,111,196883,5573,5576,108,112,107,109,115,5567	ADCY8,PRKACG,PRKAR1B,PRKAR2B,ADCY7,PRKACA,ADCY5,ADCY4,PRKAR1A,PRKAR2A,ADCY2,ADCY6,ADCY1,ADCY3,ADCY9,PRKACB
R-HSA-5637812	Signaling by EGFRvIII in Cancer	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	6464,3845,5295,11140,3265,2549,4893,2885,3320,5290,867,6654,1950,1956,5335,100302213	SHC1,KRAS,PIK3R1,CDC37,HRAS,GAB1,NRAS,GRB2,HSP90AA1,PIK3CA,CBL,SOS1,EGF,EGFR,PLCG1,MIR1181
R-HSA-918233	TRAF3-dependent IRF activation pathway	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	3661,80143,1387,7187,9641,7706,23586,29110,3665,3456,64135,84282,100500827,2033,100302237,57506	IRF3,SIKE1,CREBBP,TRAF3,IKBKE,TRIM25,RIGI,TBK1,IRF7,IFNB1,IFIH1,RNF135,MIR3614,EP300,MIR1281,MAVS
R-HSA-549132	Organic cation/anion/zwitterion transport	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	100506403,5002,6248,116085,55356,6581,6580,6582,55867,85413,10864,861,9376,6583,9356,6584	LOC100506403,SLC22A18,RSC1A1,SLC22A12,SLC22A15,SLC22A3,SLC22A1,SLC22A2,SLC22A11,SLC22A16,SLC22A7,RUNX1,SLC22A8,SLC22A4,SLC22A6,SLC22A5
R-HSA-1963642	PI3K events in ERBB2 signaling	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	3084,5295,145957,10718,2064,2069,2066,2549,2885,5290,9542,2065,1839,1950,1956,685	NRG1,PIK3R1,NRG4,NRG3,ERBB2,EREG,ERBB4,GAB1,GRB2,PIK3CA,NRG2,ERBB3,HBEGF,EGF,EGFR,BTC
R-HSA-110312	Translesion synthesis by REV1	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	6119,7314,6233,5981,5111,5985,7316,6118,51455,6117,10459,7311,5983,5984,5982,5980	RPA3,UBB,RPS27A,RFC1,PCNA,RFC5,UBC,RPA2,REV1,RPA1,MAD2L2,UBA52,RFC3,RFC4,RFC2,REV3L
R-HSA-392517	Rap1 signalling	0.125345922058021	-2.07667798735201	16	16	0.0017710870046491	9034	10285	10235,5568,11069,5909,5906,5908,10411,7529,5566,7534,23108,5894,5592,10125,5567,6494	RASGRP2,PRKACG,RAPGEF4,RAP1GAP,RAP1A,RAP1B,RAPGEF3,YWHAB,PRKACA,YWHAZ,RAP1GAP2,RAF1,PRKG1,RASGRP1,PRKACB,SIPA1
R-HSA-6811436	COPI-independent Golgi-to-ER retrograde traffic	0.128802844079737	-2.04947238419126	28	27	0.00298870932034536	9034	10285	8655,5870,8398,10540,2589,51143,84516,140735,636,1781,5049,23299,1778,1783,25782,22931,1780,2590,51560,22930,11258,5048,56894,5321,10671,1639,51164	DYNLL1,RAB6A,PLA2G6,DCTN2,GALNT1,DYNC1LI1,DCTN5,DYNLL2,BICD1,DYNC1I2,PAFAH1B2,BICD2,DYNC1H1,DYNC1LI2,RAB3GAP2,RAB18,DYNC1I1,GALNT2,RAB6B,RAB3GAP1,DCTN3,PAFAH1B1,AGPAT3,PLA2G4A,DCTN6,DCTN1,DCTN4
R-HSA-1368082	RORA activates gene expression	0.128802844079737	-2.04947238419126	28	27	0.00298870932034536	9034	10285	80205,9575,8648,5469,96764,23411,10499,79718,406,85441,1374,100302237,2033,1387,6720,4862,9611,8204,6095,8841,6604,9572,6256,23054,5465,10498,10891	CHD9,CLOCK,NCOA1,MED1,TGS1,SIRT1,NCOA2,TBL1XR1,BMAL1,HELZ2,CPT1A,MIR1281,EP300,CREBBP,SREBF1,NPAS2,NCOR1,NRIP1,RORA,HDAC3,SMARCD3,NR1D1,RXRA,NCOA6,PPARA,CARM1,PPARGC1A
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	0.128802844079737	-2.04947238419126	28	27	0.00298870932034536	9034	10285	81617,51719,10542,57521,5564,2475,6794,7248,8649,5565,389541,55437,64121,6009,5562,28956,58528,5563,64223,5494,51422,53632,5571,7249,10670,92335,55004	CAB39L,CAB39,LAMTOR5,RPTOR,PRKAB1,MTOR,STK11,TSC1,LAMTOR3,PRKAB2,LAMTOR4,STRADB,RRAGC,RHEB,PRKAA1,LAMTOR2,RRAGD,PRKAA2,MLST8,PPM1A,PRKAG2,PRKAG3,PRKAG1,TSC2,RRAGA,STRADA,LAMTOR1
R-HSA-211976	Endogenous sterols	0.128802844079737	-2.04947238419126	28	27	0.00298870932034536	9034	10285	196,1595,285440,5740,405,1582,1589,6256,1583,10499,1585,9915,5443,8648,1581,9420,51302,1586,2230,2232,1545,1593,1584,9971,112812,1588,10858	AHR,CYP51A1,CYP4V2,PTGIS,ARNT,CYP8B1,CYP21A2,RXRA,CYP11A1,NCOA2,CYP11B2,ARNT2,POMC,NCOA1,CYP7A1,CYP7B1,CYP39A1,CYP17A1,FDX1,FDXR,CYP1B1,CYP27A1,CYP11B1,NR1H4,FDX2,CYP19A1,CYP46A1
R-HSA-400042	Adrenaline,noradrenaline inhibits insulin secretion	0.128802844079737	-2.04947238419126	28	27	0.00298870932034536	9034	10285	54331,2787,55970,152,94235,2770,2790,2792,111,9254,783,2786,775,2784,2788,784,2793,112,51764,10681,150,776,59345,2771,2791,2782,2783	GNG2,GNG5,GNG12,ADRA2C,GNG8,GNAI1,GNG10,GNGT1,ADCY5,CACNA2D2,CACNB2,GNG4,CACNA1C,GNB3,GNG7,CACNB3,GNGT2,ADCY6,GNG13,GNB5,ADRA2A,CACNA1D,GNB4,GNAI2,GNG11,GNB1,GNB2
R-HSA-69236	G1 Phase	0.130562743930001	-2.03590137136646	39	37	0.00409563869825105	9034	10285	1874,1028,5519,1031,1026,4331,6502,6500,6233,595,1871,5934,1021,1869,1027,5925,1019,7027,902,1875,7311,894,5516,8454,1022,5518,1029,896,7029,1870,7314,5933,5515,5520,1032,1030,7316	E2F4,CDKN1C,PPP2R1B,CDKN2C,CDKN1A,MNAT1,SKP2,SKP1,RPS27A,CCND1,E2F3,RBL2,CDK6,E2F1,CDKN1B,RB1,CDK4,TFDP1,CCNH,E2F5,UBA52,CCND2,PPP2CB,CUL1,CDK7,PPP2R1A,CDKN2A,CCND3,TFDP2,E2F2,UBB,RBL1,PPP2CA,PPP2R2A,CDKN2D,CDKN2B,UBC
R-HSA-69231	Cyclin D associated events in G1	0.130562743930001	-2.03590137136646	39	37	0.00409563869825105	9034	10285	5518,1022,896,1029,7029,1870,7311,894,5516,8454,1032,1030,7316,7314,5933,5520,5515,1026,4331,6502,6500,1874,1028,5519,1031,1869,1027,5925,7027,1019,902,1875,6233,595,1871,5934,1021	PPP2R1A,CDK7,CCND3,CDKN2A,TFDP2,E2F2,UBA52,CCND2,PPP2CB,CUL1,CDKN2D,CDKN2B,UBC,UBB,RBL1,PPP2R2A,PPP2CA,CDKN1A,MNAT1,SKP2,SKP1,E2F4,CDKN1C,PPP2R1B,CDKN2C,E2F1,CDKN1B,RB1,TFDP1,CDK4,CCNH,E2F5,RPS27A,CCND1,E2F3,RBL2,CDK6
R-HSA-1650814	Collagen biosynthesis and modifying enzymes	0.131022263890261	-2.03238801686065	70	65	0.00719504095638698	9034	10285	55214,10536,1280,1296,1308,871,5034,1306,1278,1298,140766,81578,23127,1277,1297,1301,1295,50509,1307,1305,100313843,5351,1286,649,1290,5118,1303,1300,100126326,1293,169044,7092,136227,9509,1285,64175,8985,1310,10491,1281,1282,9508,1289,255631,1294,8974,256076,100500837,79709,5352,131873,5479,7093,1299,7373,85301,5033,340267,1302,283208,84570,1284,26577,91522,57642	P3H2,P3H3,COL2A1,COL8A2,COL17A1,SERPINH1,P4HB,COL15A1,COL1A2,COL9A2,ADAMTS14,COL21A1,COLGALT2,COL1A1,COL9A1,COL11A1,COL8A1,COL5A3,COL16A1,COL13A1,MIR711,PLOD1,COL4A4,BMP1,COL5A2,PCOLCE,COL12A1,COL10A1,MIR936,COL6A3,COL22A1,TLL1,COL26A1,ADAMTS2,COL4A3,P3H1,PLOD3,COL19A1,CRTAP,COL3A1,COL4A1,ADAMTS3,COL5A1,COL24A1,COL7A1,P4HA2,COL6A5,MIR3606,COLGALT1,PLOD2,COL6A6,PPIB,TLL2,COL9A3,COL14A1,COL27A1,P4HA1,COL28A1,COL11A2,P4HA3,COL25A1,COL4A2,PCOLCE2,COL23A1,COL20A1
R-HSA-211945	Phase 1 - Functionalization of compounds	0.131624754154187	-2.0278001763042	109	100	0.0110692937790569	9034	10285	1548,1585,9915,8529,284541,10728,2230,57834,13,6916,4835,1586,1565,64816,112812,84532,1553,126410,1595,1543,1577,64757,8824,2326,1066,100861540,1576,1580,3326,2327,6256,1558,874,1544,10499,216,9420,128,1559,2232,1592,1572,218,54996,26,10858,126,11283,1562,405,2052,127,1549,285440,219,1727,217,1582,131,23491,5447,1581,80777,55902,8648,51302,1588,54905,1573,1593,1545,1557,2328,66002,1555,196,5740,9049,1591,8639,56603,1583,120227,57491,5443,113612,134147,1579,124,670,314,1584,9971,29785,130,125,5742,1589,1594,54498	CYP2A6,CYP11B2,ARNT2,CYP4F2,CYP4A22,PTGES3,FDX1,CYP4F11,AADAC,TBXAS1,NQO2,CYP17A1,CYP2D6,CYP3A43,FDX2,ACSS1,CYP2A13,CYP4F22,CYP51A1,CYP1A1,CYP3A5,MTARC1,CES2,FMO1,CES1,CYP3A7-CYP3A51P,CYP3A4,CYP4B1,HSP90AB1,FMO2,RXRA,CYP2C8,CBR3,CYP1A2,NCOA2,ALDH1A1,CYP7B1,ADH5,CYP2C9,FDXR,CYP26A1,CYP2F1,ALDH3A1,MTARC2,AOC1,CYP46A1,ADH1C,CYP4F8,CYP2C18,ARNT,EPHX1,ADH4,CYP2A7,CYP4V2,ALDH1B1,CYB5R3,ALDH2,CYP8B1,ADH7,CES3,POR,CYP7A1,CYB5B,ACSS2,NCOA1,CYP39A1,CYP19A1,CYP2W1,CYP2J2,CYP27A1,CYP1B1,CYP2C19,FMO3,CYP4F12,CYP2B6,AHR,PTGIS,AIP,CYP24A1,AOC3,CYP26B1,CYP11A1,CYP2R1,AHRR,POMC,CYP2U1,CMBL,CYP4A11,ADH1A,BPHL,AOC2,CYP11B1,NR1H4,CYP2S1,ADH6,ADH1B,PTGS1,CYP21A2,CYP27B1,SMOX
R-HSA-6783783	Interleukin-10 signaling	0.137157768513911	-1.98662342073885	49	46	0.00509187513836617	9034	10285	3627,3554,3569,6774,1234,6351,6363,3592,6367,3552,942,6347,5724,1437,6348,1435,7297,7132,3576,3596,7124,2920,5743,3557,941,6349,3976,414062,3716,3383,3586,6352,3565,7850,2357,3588,3553,3593,729230,7133,3606,1230,3587,2208,2919,6364	CXCL10,IL1R1,IL6,STAT3,CCR5,CCL4,CCL19,IL12A,CCL22,IL1A,CD86,CCL2,PTAFR,CSF2,CCL3,CSF1,TYK2,TNFRSF1A,CXCL8,IL13,TNF,CXCL2,PTGS2,IL1RN,CD80,CCL3L1,LIF,CCL3L3,JAK1,ICAM1,IL10,CCL5,IL4,IL1R2,FPR1,IL10RB,IL1B,IL12B,CCR2,TNFRSF1B,IL18,CCR1,IL10RA,FCER2,CXCL1,CCL20
R-HSA-909733	Interferon alpha/beta signaling	0.140061361199436	-1.96567465811403	69	64	0.00708434801859641	9034	10285	6041,684,3444,3660,3394,103,9636,3663,3452,3437,8638,2537,7297,9021,6772,10410,4939,3449,4940,10379,8519,3442,54739,3433,3429,3665,3134,4600,3661,3454,91543,2634,3448,3662,3669,5770,3716,3106,4938,4599,3434,3441,6773,3133,3107,25939,3105,5781,3445,3439,3455,3443,5696,3135,10581,3440,3664,3456,5777,51447,3659,1958,8651,3136	RNASEL,BST2,IFNA7,IRF2,IRF8,ADAR,ISG15,IRF5,IFNA21,IFIT3,OASL,IFI6,TYK2,SOCS3,STAT1,IFITM3,OAS2,IFNA16,OAS3,IRF9,IFITM1,IFNA5,XAF1,IFIT2,IFI27,IRF7,HLA-F,MX2,IRF3,IFNAR1,RSAD2,GBP2,IFNA14,IRF4,ISG20,PTPN1,JAK1,HLA-B,OAS1,MX1,IFIT1,IFNA4,STAT2,HLA-E,HLA-C,SAMHD1,HLA-A,PTPN11,IFNA8,IFNA1,IFNAR2,IFNA6,PSMB8,HLA-G,IFITM2,IFNA2,IRF6,IFNB1,PTPN6,IP6K2,IRF1,EGR1,SOCS1,HLA-H
R-HSA-5685938	HDR through Single Strand Annealing (SSA)	0.142431447505873	-1.94889446515902	38	36	0.00398494576046048	9034	10285	580,9156,5984,672,83990,6117,5810,4361,144715,10111,5884,3364,5888,5893,641,6118,2072,25,545,5985,2067,5983,472,10524,116028,1763,83695,7156,11073,5982,5883,6119,4683,7486,84126,80010	BARD1,EXO1,RFC4,BRCA1,BRIP1,RPA1,RAD1,MRE11,RAD9B,RAD50,RAD17,HUS1,RAD51,RAD52,BLM,RPA2,ERCC4,ABL1,ATR,RFC5,ERCC1,RFC3,ATM,KAT5,RMI2,DNA2,RHNO1,TOP3A,TOPBP1,RFC2,RAD9A,RPA3,NBN,WRN,ATRIP,RMI1
R-HSA-156590	Glutathione conjugation	0.142431447505873	-1.94889446515902	38	36	0.00398494576046048	9034	10285	2949,79094,2940,27306,2687,494143,2939,124975,2679,9446,10327,2954,2686,55748,4259,2098,2946,2938,2730,221357,2948,91227,79017,2944,373156,4257,4258,119391,2947,2953,2729,2952,2937,2950,2941,2678	GSTM5,CHAC1,GSTA3,HPGDS,GGT5,CHAC2,GSTA2,GGT6,GGT3P,GSTO1,AKR1A1,GSTZ1,GGT7,CNDP2,MGST3,ESD,GSTM2,GSTA1,GCLM,GSTA5,GSTM4,GGTLC2,GGCT,GSTM1,GSTK1,MGST1,MGST2,GSTO2,GSTM3,GSTT2,GCLC,GSTT1,GSS,GSTP1,GSTA4,GGT1
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	0.142512613840376	-1.94832476501286	27	26	0.00287801638255479	9034	10285	7040,7314,9110,7316,25805,9958,9372,7311,23645,57154,5501,5500,4087,7046,56937,6233,23327,7514,64750,7048,5499,4092,51377,11171,10273,4088	TGFB1,UBB,MTMR4,UBC,BAMBI,USP15,ZFYVE9,UBA52,PPP1R15A,SMURF1,PPP1CC,PPP1CB,SMAD2,TGFBR1,PMEPA1,RPS27A,NEDD4L,XPO1,SMURF2,TGFBR2,PPP1CA,SMAD7,UCHL5,STRAP,STUB1,SMAD3
R-HSA-400685	Sema4D in semaphorin signaling	0.142512613840376	-1.94832476501286	27	26	0.00287801638255479	9034	10285	10507,4233,3984,387,103910,391,389,79784,4629,5880,23365,5364,3985,2909,6237,998,9475,388,4628,4637,5879,9826,2064,10398,27289,4627	SEMA4D,MET,LIMK1,RHOA,MYL12B,RHOG,RHOC,MYH14,MYH11,RAC2,ARHGEF12,PLXNB1,LIMK2,ARHGAP35,RRAS,CDC42,ROCK2,RHOB,MYH10,MYL6,RAC1,ARHGEF11,ERBB2,MYL9,RND1,MYH9
R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	0.142512613840376	-1.94832476501286	27	26	0.00287801638255479	9034	10285	8831,5879,161742,1793,9564,9844,5921,10156,8437,200734,3265,5829,63916,100847012,64926,387,153090,5753,5922,4893,2909,9462,4763,1398,399473,3845	SYNGAP1,RAC1,SPRED1,DOCK1,BCAR1,ELMO1,RASA1,RASA4,RASAL1,SPRED2,HRAS,PXN,ELMO2,MIR5004,RASAL3,RHOA,DAB2IP,PTK6,RASA2,NRAS,ARHGAP35,RASAL2,NF1,CRK,SPRED3,KRAS
R-HSA-114508	Effects of PIP2 hydrolysis	0.142512613840376	-1.94832476501286	27	26	0.00287801638255479	9034	10285	3710,11343,10235,5581,8527,8525,9162,1609,3709,7225,5588,57113,8526,1607,7222,747,160851,1606,26090,10125,5580,221955,5583,3708,57406,1608	ITPR3,MGLL,RASGRP2,PRKCE,DGKD,DGKZ,DGKI,DGKQ,ITPR2,TRPC6,PRKCQ,TRPC7,DGKE,DGKB,TRPC3,DAGLA,DGKH,DGKA,ABHD12,RASGRP1,PRKCD,DAGLB,PRKCH,ITPR1,ABHD6,DGKG
R-HSA-6783589	Interleukin-6 family signaling	0.142512613840376	-1.94832476501286	27	26	0.00287801638255479	9034	10285	246778,3572,3592,3570,3590,3716,9021,5781,6772,1271,9244,867,3717,7297,9466,3977,9180,1270,10148,23529,3976,1489,3595,6774,3569,5008	IL27,IL6ST,IL12A,IL6R,IL11RA,JAK1,SOCS3,PTPN11,STAT1,CNTFR,CRLF1,CBL,JAK2,TYK2,IL27RA,LIFR,OSMR,CNTF,EBI3,CLCF1,LIF,CTF1,IL12RB2,STAT3,IL6,OSM
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	80270,10499,1581,5740,1645,9420,8648,8644,6718,1582,1646,9971,1109,1593,6256	HSD3B7,NCOA2,CYP7A1,PTGIS,AKR1C1,CYP7B1,NCOA1,AKR1C3,AKR1D1,CYP8B1,AKR1C2,NR1H4,AKR1C4,CYP27A1,RXRA
R-HSA-170670	Adenylate cyclase inhibitory pathway	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	111,113,2770,2774,2773,114,108,346562,109,107,112,115,2771,196883,406974	ADCY5,ADCY7,GNAI1,GNAL,GNAI3,ADCY8,ADCY2,GNAT3,ADCY3,ADCY1,ADCY6,ADCY9,GNAI2,ADCY4,MIR197
R-HSA-156581	Methylation	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	57412,4552,7172,4837,9446,100616414,27430,1312,4548,191,29104,1544,4143,4144,51504	AS3MT,MTRR,TPMT,NNMT,GSTO1,MIR4761,MAT2B,COMT,MTR,AHCY,N6AMT1,CYP1A2,MAT1A,MAT2A,TRMT112
R-HSA-430039	mRNA decay by 5' to 3' exoribonuclease	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	196513,25804,55802,51690,57819,219988,11157,54464,1656,23644,23658,27257,27258,167227,80153	DCP1B,LSM4,DCP1A,LSM7,LSM2,PATL1,LSM6,XRN1,DDX6,EDC4,LSM5,LSM1,LSM3,DCP2,EDC3
R-HSA-3772470	Negative regulation of TCF-dependent signaling by WNT ligand antagonists	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	7483,27121,89780,6422,54361,4040,7474,50964,6423,83999,79412,22943,4041,11197,27123	WNT9A,DKK4,WNT3A,SFRP1,WNT4,LRP6,WNT5A,SOST,SFRP2,KREMEN1,KREMEN2,DKK1,LRP5,WIF1,DKK2
R-HSA-997269	Inhibition of adenylate cyclase pathway	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	196883,406974,2771,115,112,109,107,108,346562,2774,2773,114,111,2770,113	ADCY4,MIR197,GNAI2,ADCY9,ADCY6,ADCY3,ADCY1,ADCY2,GNAT3,GNAL,GNAI3,ADCY8,ADCY5,GNAI1,ADCY7
R-HSA-5099900	WNT5A-dependent internalization of FZD4	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	160,1856,1211,1173,1175,5578,409,161,7474,1213,163,5582,1212,8322,5579	AP2A1,DVL2,CLTA,AP2M1,AP2S1,PRKCA,ARRB2,AP2A2,WNT5A,CLTC,AP2B1,PRKCG,CLTB,FZD4,PRKCB
R-HSA-975577	N-Glycan antennae elongation	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	8703,8704,2683,11282,11320,9331,8702,338596,6484,25834,4249,51046,8128,9334,6480	B4GALT3,B4GALT2,B4GALT1,MGAT4B,MGAT4A,B4GALT6,B4GALT4,ST8SIA6,ST3GAL4,MGAT4C,MGAT5,ST8SIA3,ST8SIA2,B4GALT5,ST6GAL1
R-HSA-6785631	ERBB2 Regulates Cell Motility	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	685,1839,1950,1956,2065,1729,387,9542,2069,2066,145957,10718,2064,51072,3084	BTC,HBEGF,EGF,EGFR,ERBB3,DIAPH1,RHOA,NRG2,EREG,ERBB4,NRG4,NRG3,ERBB2,MEMO1,NRG1
R-HSA-69298	Association of licensing factors with the pre-replicative complex	0.14273230064584	-1.9467844266037	15	15	0.00166039406685853	9034	10285	1869,51053,4998,7316,5000,7314,6233,1871,81620,23595,4999,1870,990,5001,7311	E2F1,GMNN,ORC1,UBC,ORC4,UBB,RPS27A,E2F3,CDT1,ORC3,ORC2,E2F2,CDC6,ORC5,UBA52
R-HSA-166016	Toll Like Receptor 4 (TLR4) Cascade	0.145765907855898	-1.92575331489849	126	115	0.0127296878459154	9034	10285	671,4205,5598,7316,4615,8737,9252,353376,330,1849,10392,3665,23291,4792,3929,9450,5601,11213,5519,1147,59307,5970,8945,5608,466,64127,29110,4214,51295,7097,148022,5594,57162,9641,1848,9261,5609,7323,6288,8454,5518,7096,7867,5336,10454,7189,7321,7334,5775,5599,6195,4790,1385,4064,841,6283,6196,23118,1386,5604,6500,3656,57161,7311,10333,1660,5600,4208,948,5595,8772,351,7322,11035,6233,23643,3146,6885,3661,5528,7187,329,26052,5606,1785,3725,7099,177,7335,7314,1846,929,3689,79155,5515,51231,5781,5602,7098,5516,4791,246330,8767,6416,1759,2353,8651,4793,3551,3684,1432,10010,114609,51135,1326	BPI,MEF2A,MAPK7,UBC,MYD88,RIPK1,RPS6KA5,TICAM2,BIRC3,DUSP7,NOD1,IRF7,FBXW11,NFKBIA,LBP,LY86,MAPK9,IRAK3,PPP2R1B,CHUK,SIGIRR,RELA,BTRC,MAP2K6,ATF1,NOD2,TBK1,MAP3K1,ECSIT,TLR2,TICAM1,MAPK1,PELI1,IKBKE,DUSP6,MAPKAPK2,MAP2K7,UBE2D3,SAA1,CUL1,PPP2R1A,TLR1,MAPKAPK3,PLCG2,TAB1,TRAF6,UBE2D1,UBE2N,PTPN4,MAPK8,RPS6KA1,NFKB1,CREB1,CD180,CASP8,S100A12,RPS6KA2,TAB2,ATF2,MAP2K1,SKP1,IRAK2,PELI2,UBA52,TLR6,DHX9,MAPK11,MEF2C,CD36,MAPK3,FADD,APP,UBE2D2,RIPK3,RPS27A,LY96,HMGB1,MAP3K7,IRF3,PPP2R5D,TRAF3,BIRC2,DNM3,MAP2K3,DNM2,JUN,TLR4,AGER,UBE2V1,UBB,DUSP4,CD14,ITGB2,TNIP2,PPP2CA,VRK3,PTPN11,MAPK10,TLR3,PPP2CB,NFKB2,PELI3,RIPK2,MAP2K4,DNM1,FOS,SOCS1,NFKBIB,IKBKB,ITGAM,MAPK14,TANK,TIRAP,IRAK4,MAP3K8
R-HSA-380108	Chemokine receptors bind chemokines	0.148212507318443	-1.90910817481991	48	45	0.0049811822005756	9034	10285	3579,58191,6352,6370,51554,6372,10850,6373,7852,1524,6387,6366,729230,643,1230,1232,2921,2826,6346,2919,10563,9034,1233,6364,10803,3576,1237,6376,1235,3627,2920,6374,10663,6360,3577,1236,6357,6375,56477,6846,2829,1234,5196,57007,6363	CXCR2,CXCL16,CCL5,CCL25,ACKR4,CXCL6,CCL27,CXCL11,CXCR4,CX3CR1,CXCL12,CCL21,CCR2,CXCR5,CCR1,CCR3,CXCL3,CCR10,CCL1,CXCL1,CXCL13,CCRL2,CCR4,CCL20,CCR9,CXCL8,CCR8,CX3CL1,CCR6,CXCL10,CXCL2,CXCL5,CXCR6,CCL16,CXCR1,CCR7,CCL13,XCL1,CCL28,XCL2,XCR1,CCR5,PF4,ACKR3,CCL19
R-HSA-3238698	WNT ligand biogenesis and trafficking	0.157544928330151	-1.84804460215608	26	25	0.00276732344476422	9034	10285	8724,55737,79971,80326,7481,7479,81029,7472,54361,50999,7473,7484,7475,7477,51384,7471,9559,51699,7482,7480,7476,7474,7478,7483,89780	SNX3,VPS35,WLS,WNT10A,WNT11,WNT8B,WNT5B,WNT2,WNT4,TMED5,WNT3,WNT9B,WNT6,WNT7B,WNT16,WNT1,VPS26A,VPS29,WNT2B,WNT10B,WNT7A,WNT5A,WNT8A,WNT9A,WNT3A
R-HSA-177504	Retrograde neurotrophin signalling	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	160,1211,4914,4803,1173,1785,161,1213,26052,6456,163,1175,10126,1759	AP2A1,CLTA,NTRK1,NGF,AP2M1,DNM2,AP2A2,CLTC,DNM3,SH3GL2,AP2B1,AP2S1,DNAL4,DNM1
R-HSA-428790	Facilitative Na+-independent glucose transporters	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	66035,11182,155184,154091,29988,56606,81031,6518,6513,6514,6517,26291,6515,144195	SLC2A11,SLC2A6,SLC2A7,SLC2A12,SLC2A8,SLC2A9,SLC2A10,SLC2A5,SLC2A1,SLC2A2,SLC2A4,FGF21,SLC2A3,SLC2A14
R-HSA-622327	Postsynaptic nicotinic acetylcholine receptors	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	1136,1139,1144,1143,1138,1142,55584,1146,1134,8973,1137,1135,1141,1145	CHRNA3,CHRNA7,CHRND,CHRNB4,CHRNA5,CHRNB3,CHRNA9,CHRNG,CHRNA1,CHRNA6,CHRNA4,CHRNA2,CHRNB2,CHRNE
R-HSA-181431	Acetylcholine Binding And Downstream Events	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	1143,1144,1139,1136,1134,1142,1138,1146,55584,1135,1141,8973,1137,1145	CHRNB4,CHRND,CHRNA7,CHRNA3,CHRNA1,CHRNB3,CHRNA5,CHRNG,CHRNA9,CHRNA2,CHRNB2,CHRNA6,CHRNA4,CHRNE
R-HSA-1250347	SHC1 events in ERBB4 signaling	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	9542,6654,1839,685,6464,3845,3084,145957,10718,3265,2066,2069,2885,4893	NRG2,SOS1,HBEGF,BTC,SHC1,KRAS,NRG1,NRG4,NRG3,HRAS,ERBB4,EREG,GRB2,NRAS
R-HSA-209952	Peptide hormone biosynthesis	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	2488,1082,93659,7252,3625,3972,94115,3623,5122,3624,3626,1081,83729,5443	FSHB,CGB3,CGB5,TSHB,INHBB,LHB,CGB8,INHA,PCSK1,INHBA,INHBC,CGA,INHBE,POMC
R-HSA-162594	Early Phase of HIV Life Cycle	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	2547,7518,1234,3836,8815,3978,2237,920,3159,7852,11168,5478,3981,7520	XRCC6,XRCC4,CCR5,KPNA1,BANF1,LIG1,FEN1,CD4,HMGA1,CXCR4,PSIP1,PPIA,LIG4,XRCC5
R-HSA-629602	Activation of Nicotinic Acetylcholine Receptors	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	1145,1141,1135,8973,1137,1134,1138,1142,1146,55584,1143,1144,1136,1139	CHRNE,CHRNB2,CHRNA2,CHRNA6,CHRNA4,CHRNA1,CHRNA5,CHRNB3,CHRNG,CHRNA9,CHRNB4,CHRND,CHRNA3,CHRNA7
R-HSA-418885	DCC mediated attractive signaling	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	5747,998,84448,2534,7204,6714,1630,8976,5879,1793,4690,22885,3983,9423	PTK2,CDC42,ABLIM2,FYN,TRIO,SRC,DCC,WASL,RAC1,DOCK1,NCK1,ABLIM3,ABLIM1,NTN1
R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	81876,64689,5595,2801,8615,5862,983,891,8548,5347,5861,26003,9133,5594	RAB1B,GORASP1,MAPK3,GOLGA2,USO1,RAB2A,CDK1,CCNB1,BLZF1,PLK1,RAB1A,GORASP2,CCNB2,MAPK1
R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	5457,10848,54971,25946,7157,23368,10000,208,51230,7161,207,8626,5458,7159	POU4F1,PPP1R13L,BANP,ZNF385A,TP53,PPP1R13B,AKT3,AKT2,PHF20,TP73,AKT1,TP63,POU4F2,TP53BP2
R-HSA-877312	Regulation of IFNG signaling	0.162528099770269	-1.81690437049838	14	14	0.00154970112906797	9034	10285	8651,8554,3459,5777,3717,3458,5771,9021,6772,5781,3460,5770,3716,7341	SOCS1,PIAS1,IFNGR1,PTPN6,JAK2,IFNG,PTPN2,SOCS3,STAT1,PTPN11,IFNGR2,PTPN1,JAK1,SUMO1
R-HSA-2514856	The phototransduction cascade	0.169025569494967	-1.77770527671678	36	34	0.00376355988487934	9034	10285	5145,6010,4836,9187,801,5957,10681,5578,9626,8787,2342,2868,2782,23173,805,1258,5148,2339,2979,131890,5158,10988,9397,5588,6295,2792,2779,1259,2978,6011,3000,79823,388531,808	PDE6A,RHO,NMT1,SLC24A1,CALM1,RCVRN,GNB5,PRKCA,GUCA1C,RGS9,FNTB,GRK4,GNB1,METAP1,CALM2,CNGB1,PDE6G,FNTA,GUCA1B,GRK7,PDE6B,METAP2,NMT2,PRKCQ,SAG,GNGT1,GNAT1,CNGA1,GUCA1A,GRK1,GUCY2D,CAMKMT,RGS9BP,CALM3
R-HSA-5663213	RHO GTPases Activate WASPs and WAVEs	0.169025569494967	-1.77770527671678	36	34	0.00376355988487934	9034	10285	5594,51517,10458,3071,10097,55845,998,2885,5747,10006,10096,10163,10095,10810,10092,71,23191,10094,5595,8976,10109,10787,5879,10093,25,4690,7456,147179,10552,8936,644150,60,10152,26999	MAPK1,NCKIPSD,BAIAP2,NCKAP1L,ACTR2,BRK1,CDC42,GRB2,PTK2,ABI1,ACTR3,WASF2,ARPC1B,WASF3,ARPC5,ACTG1,CYFIP1,ARPC3,MAPK3,WASL,ARPC2,NCKAP1,RAC1,ARPC4,ABL1,NCK1,WIPF1,WIPF2,ARPC1A,WASF1,WIPF3,ACTB,ABI2,CYFIP2
R-HSA-2672351	Stimuli-sensing channels	0.171694098514913	-1.76204088257847	104	95	0.0105158290901041	9034	10285	28962,133308,9635,161003,59341,285175,7220,57578,79054,7311,40,23678,1180,805,6233,23327,6339,7225,57192,57101,1187,6262,55129,10786,54831,7226,284525,55503,7442,80727,94015,338440,1186,29850,54822,65125,7314,285335,6338,56302,7222,1182,53373,219931,4308,22802,57719,51393,55515,144453,203859,196527,51802,10345,7316,55107,121601,54795,7223,57113,444,80036,6717,162514,9629,6340,6446,1188,255231,808,57348,55283,2281,5894,801,11059,65268,140803,2040,50636,63982,6261,259232,8989,6337,65266,41,7809,10110,150159,6263,7439,26133,1179,9311	OSTM1,SLC9B2,CLCA2,STOML3,TRPV4,UNC80,TRPC1,UNC79,TRPM8,UBA52,ASIC2,SGK3,CLCN1,CALM2,RPS27A,NEDD4L,SCNN1D,TRPC6,MCOLN1,ANO2,CLCNKA,RYR2,ANO10,SLC17A3,BEST2,TRPM2,SLC9C2,TRPV6,TRPV1,TTYH3,TTYH2,ANO9,CLCN7,TRPM5,TRPM7,WNK1,UBB,SLC9C1,SCNN1B,TRPV5,TRPC3,CLCN3,TPCN1,TPCN2,TRPM1,CLCA4,ANO8,TRPV2,ASIC4,BEST3,ANO5,ANO6,ASIC5,TRDN,UBC,ANO1,ANO4,TRPM4,TRPC4,TRPC7,ASPH,TRPM3,SRI,TRPV3,CLCA3P,SCNN1G,SGK1,CLCNKB,MCOLN2,CALM3,TTYH1,MCOLN3,FKBP1B,RAF1,CALM1,WWP1,WNK2,TRPM6,STOM,ANO7,ANO3,RYR1,NALCN,TRPA1,SCNN1A,WNK4,ASIC1,BSND,SGK2,SLC9B1,RYR3,BEST1,TRPC4AP,CLCA1,ASIC3
R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	0.171694098514913	-1.76204088257847	104	95	0.0105158290901041	9034	10285	55706,9688,23137,5905,9212,56160,9126,1912,7020,79023,641,53371,9656,7703,54780,8535,672,23165,6015,100101267,4286,4193,22955,142,8924,81929,129401,83746,7175,407043,6613,7158,3183,4927,648,493861,197370,7022,79902,100500853,5111,7518,7153,3619,5885,348995,7486,8554,11097,10274,332,51564,57332,6790,9818,6670,6612,9972,23225,7021,5903,23279,7341,23511,8086,6996,9631,6672,7155,4928,7157,80012,51588,51602,9883,8021,7329,6045,286053,1029,5893,1911,84733,57122,9063,55746,79677,5371,6117,23636,10762,165918,7508,3190,7150	NDC1,NUP93,SMC5,RANGAP1,AURKB,NSMCE3,SMC3,PHC2,TFAP2A,NUP37,BLM,NUP54,MDC1,PCGF2,NSMCE4A,CBX4,BRCA1,NUP205,RING1,POM121C,MITF,MDM2,SCMH1,PARP1,HERC2,SEH1L,NUP35,L3MBTL2,TPR,MIR7-1,SUMO2,TP53BP1,HNRNPC,NUP88,BMI1,EID3,NSMCE1,TFAP2C,NUP85,MIR3605,PCNA,XRCC4,TOP2A,INCENP,RAD21,NUP43,WRN,PIAS1,NUP42,STAG1,BIRC5,HDAC7,CBX8,AURKA,NUP58,SP3,SUMO3,NUP153,NUP210,TFAP2B,RANBP2,NUP160,SUMO1,NUP188,AAAS,TDG,NUP155,SP100,TOP2B,NUP98,TP53,PHC3,PIAS4,NOP58,POM121,NUP214,UBE2I,RNF2,NSMCE2,CDKN2A,RAD52,PHC1,CBX2,NUP107,PIAS2,NUP133,SMC6,PML,RPA1,NUP62,NUP50,RNF168,XPC,HNRNPK,TOP1
R-HSA-977443	GABA receptor activation	0.172428136922468	-1.7577747268625	56	52	0.00575603276510959	9034	10285	3759,55970,346562,3772,54331,109,107,94235,2558,2560,111,2555,2557,2792,2784,2567,108,2570,2550,2561,2782,2566,113,3762,2774,2787,200959,3765,9568,115,2554,3761,3773,196883,2562,2786,2569,3766,2770,2790,2793,2773,3768,2788,2559,112,2771,406974,3760,3763,114,2783	KCNJ2,GNG12,GNAT3,KCNJ15,GNG2,ADCY3,ADCY1,GNG8,GABRA5,GABRB1,ADCY5,GABRA2,GABRA4,GNGT1,GNB3,GABRG3,ADCY2,GABRR2,GABBR1,GABRB2,GNB1,GABRG2,ADCY7,KCNJ5,GNAL,GNG5,GABRR3,KCNJ9,GABBR2,ADCY9,GABRA1,KCNJ4,KCNJ16,ADCY4,GABRB3,GNG4,GABRR1,KCNJ10,GNAI1,GNG10,GNGT2,GNAI3,KCNJ12,GNG7,GABRA6,ADCY6,GNAI2,MIR197,KCNJ3,KCNJ6,ADCY8,GNB2
R-HSA-5654708	Downstream signaling of activated FGFR3	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	2250,6654,2261,2253,8074,2247,3265,6464,5295,2246,2549,8817,5290,8822,5335,2254,5781,26281,3845,10818,4893,2885,10817,2249	FGF5,SOS1,FGFR3,FGF8,FGF23,FGF2,HRAS,SHC1,PIK3R1,FGF1,GAB1,FGF18,PIK3CA,FGF17,PLCG1,FGF9,PTPN11,FGF20,KRAS,FRS2,NRAS,GRB2,FRS3,FGF4
R-HSA-5654700	FRS-mediated FGFR2 signaling	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	10818,3845,26281,27006,2255,10817,2249,2251,2263,4893,2885,8822,8817,5781,2254,2248,3265,2246,6654,2250,2252,2247,8074,2253	FRS2,KRAS,FGF20,FGF22,FGF10,FRS3,FGF4,FGF6,FGFR2,NRAS,GRB2,FGF17,FGF18,PTPN11,FGF9,FGF3,HRAS,FGF1,SOS1,FGF5,FGF7,FGF2,FGF23,FGF8
R-HSA-182971	EGFR downregulation	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	6233,1956,5782,29924,5796,5774,10253,7314,58513,10252,867,10254,8874,9146,6456,7316,1950,7311,8027,2885,998,6457,6455,2060	RPS27A,EGFR,PTPN12,EPN1,PTPRK,PTPN3,SPRY2,UBB,EPS15L1,SPRY1,CBL,STAM2,ARHGEF7,HGS,SH3GL2,UBC,EGF,UBA52,STAM,GRB2,CDC42,SH3GL3,SH3GL1,EPS15
R-HSA-3000157	Laminin interactions	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	3672,3679,3908,3911,3688,100616340,3915,3673,3918,100422894,10319,3914,3685,4811,284217,3909,22795,3339,3675,3655,3913,3910,3912,3691	ITGA1,ITGA7,LAMA2,LAMA5,ITGB1,MIR4758,LAMC1,ITGA2,LAMC2,MIR4260,LAMC3,LAMB3,ITGAV,NID1,LAMA1,LAMA3,NID2,HSPG2,ITGA3,ITGA6,LAMB2,LAMA4,LAMB1,ITGB4
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	10484,821,3134,3133,64167,3107,3105,3136,6891,51128,811,9871,567,51752,10802,6396,6890,6892,22872,3106,3135,9632,3309,10427	SEC23A,CANX,HLA-F,HLA-E,ERAP2,HLA-C,HLA-A,HLA-H,TAP2,SAR1B,CALR,SEC24D,B2M,ERAP1,SEC24A,SEC13,TAP1,TAPBP,SEC31A,HLA-B,HLA-G,SEC24C,HSPA5,SEC24B
R-HSA-3295583	TRP channels	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	59341,56302,7223,54795,4308,140803,8989,7222,79054,7220,80036,162514,57192,57113,51393,7225,55283,7442,26133,54822,29850,55503,255231,7226	TRPV4,TRPV5,TRPC4,TRPM4,TRPM1,TRPM6,TRPA1,TRPC3,TRPM8,TRPC1,TRPM3,TRPV3,MCOLN1,TRPC7,TRPV2,TRPC6,MCOLN3,TRPV1,TRPC4AP,TRPM7,TRPM5,TRPV6,MCOLN2,TRPM2
R-HSA-1614635	Sulfur amino acid metabolism	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	58472,635,7263,4548,191,4143,2730,875,84245,1468,4552,23743,55256,58478,51074,2729,6821,84890,4507,1036,51380,55748,2805,1491	SQOR,BHMT,TST,MTR,AHCY,MAT1A,GCLM,CBS,MRI1,SLC25A10,MTRR,BHMT2,ADI1,ENOPH1,APIP,GCLC,SUOX,ADO,MTAP,CDO1,CSAD,CNDP2,GOT1,CTH
R-HSA-418592	ADP signalling through P2Y purinoceptor 1	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	2782,5321,2776,2783,2769,51764,5028,59345,2791,10681,2786,2767,6714,1432,2790,2792,2793,9630,2788,2784,2787,55970,54331,94235	GNB1,PLA2G4A,GNAQ,GNB2,GNA15,GNG13,P2RY1,GNB4,GNG11,GNB5,GNG4,GNA11,SRC,MAPK14,GNG10,GNGT1,GNGT2,GNA14,GNG7,GNB3,GNG5,GNG12,GNG2,GNG8
R-HSA-1296041	Activation of G protein gated Potassium channels	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	3760,3762,2782,2783,3763,2550,2790,3766,2792,2786,2784,2788,3768,2793,9568,54331,3765,3772,3759,2787,55970,3773,3761,94235	KCNJ3,KCNJ5,GNB1,GNB2,KCNJ6,GABBR1,GNG10,KCNJ10,GNGT1,GNG4,GNB3,GNG7,KCNJ12,GNGT2,GABBR2,GNG2,KCNJ9,KCNJ15,KCNJ2,GNG5,GNG12,KCNJ16,KCNJ4,GNG8
R-HSA-1296059	G protein gated Potassium channels	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	3760,3762,2782,2783,3763,2550,2790,3766,2792,2786,2784,2788,3768,2793,9568,54331,3765,3772,3759,55970,2787,3773,3761,94235	KCNJ3,KCNJ5,GNB1,GNB2,KCNJ6,GABBR1,GNG10,KCNJ10,GNGT1,GNG4,GNB3,GNG7,KCNJ12,GNGT2,GABBR2,GNG2,KCNJ9,KCNJ15,KCNJ2,GNG12,GNG5,KCNJ16,KCNJ4,GNG8
R-HSA-997272	Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	2550,2783,3763,3760,3762,2782,3773,3761,94235,54331,3765,9568,55970,2787,3759,3772,2788,2784,2793,3768,3766,2790,2792,2786	GABBR1,GNB2,KCNJ6,KCNJ3,KCNJ5,GNB1,KCNJ16,KCNJ4,GNG8,GNG2,KCNJ9,GABBR2,GNG12,GNG5,KCNJ2,KCNJ15,GNG7,GNB3,GNGT2,KCNJ12,KCNJ10,GNG10,GNGT1,GNG4
R-HSA-389661	Glyoxylate metabolism and glycine degradation	0.174002765178705	-1.74868408806224	25	24	0.00265663050697365	9034	10285	9380,54363,27232,1610,5162,2653,1738,2731,1737,8528,275,51601,593,1743,594,8050,4967,64902,55526,1629,387787,189,11019,4706	GRHPR,HAO1,GNMT,DAO,PDHB,GCSH,DLD,GLDC,DLAT,DDO,AMT,LIPT1,BCKDHA,DLST,BCKDHB,PDHX,OGDH,AGXT2,DHTKD1,DBT,LIPT2,AGXT,LIAS,NDUFAB1
R-HSA-3858494	Beta-catenin independent WNT signaling	0.181285394157253	-1.70768272620266	149	135	0.0149435466017268	9034	10285	10213,5720,2784,1856,7471,5698,5592,8322,27161,5714,94235,1855,5691,161,7976,1857,1213,7855,5702,7481,5693,1211,387,5145,51764,7314,5582,5331,5719,54361,5216,5706,2788,5711,144165,5534,5694,2793,6233,23236,6885,4920,5707,409,5718,7474,192670,7311,5699,6932,8325,4919,5700,57154,805,5684,2783,6259,1499,4343,5713,1175,2791,5880,5696,2792,3710,5704,5330,27327,160,54331,26523,5695,5158,55970,5579,23112,5879,64750,57690,5690,2782,5686,5530,815,5148,81029,5687,23513,5685,23002,8324,10681,801,3708,59345,163,51176,5881,2790,5682,5715,2786,83439,1173,5717,5708,9861,808,6934,1212,2787,3709,4772,57216,8323,5701,5593,5692,2780,10197,5532,9491,8321,122706,2535,5710,143471,5578,100126338,23198,7316,7979,192669	PSMD14,PSME1,GNB3,DVL2,WNT1,PSMB9,PRKG1,FZD4,AGO2,PSMD8,GNG8,DVL1,PSMB3,AP2A2,FZD3,DVL3,CLTC,FZD5,PSMC3,WNT11,PSMB5,CLTA,RHOA,PDE6A,GNG13,UBB,PRKCG,PLCB3,PSMD13,WNT4,PFN1,PSMC6,GNG7,PSMD5,PRICKLE1,PPP3R1,PSMB6,GNGT2,RPS27A,PLCB1,MAP3K7,ROR2,PSMD1,ARRB2,PSMD12,WNT5A,AGO4,UBA52,PSMB10,TCF7,FZD8,ROR1,PSMC1,SMURF1,CALM2,PSMA3,GNB2,RYK,CTNNB1,MOV10,PSMD7,AP2S1,GNG11,RAC2,PSMB8,GNGT1,ITPR3,PSMC4,PLCB2,TNRC6A,AP2A1,GNG2,AGO1,PSMB7,PDE6B,GNG12,PRKCB,TNRC6B,RAC1,SMURF2,TNRC6C,PSMB2,GNB1,PSMA5,PPP3CA,CAMK2A,PDE6G,WNT5B,PSMA6,SCRIB,PSMA4,DAAM1,FZD7,GNB5,CALM1,ITPR1,GNB4,AP2B1,LEF1,RAC3,GNG10,PSMA1,PSMD9,GNG4,TCF7L1,AP2M1,PSMD11,PSMD2,PSMD6,CALM3,TCF7L2,CLTB,GNG5,ITPR2,NFATC1,VANGL2,FZD6,PSMC2,PRKG2,PSMB4,GNAT2,PSME3,PPP3CB,PSMF1,FZD1,PSMB11,FZD2,PSMD4,PSMA8,PRKCA,MIR937,PSME4,UBC,SEM1,AGO3
R-HSA-913709	O-linked glycosylation of mucins	0.181468338500865	-1.70667408401568	65	60	0.00664157626743414	9034	10285	2589,10164,11227,117248,26290,10071,79623,10331,168391,50614,146712,143662,2650,4583,57452,56667,6487,11226,6483,10610,140687,4585,140453,9334,10678,6480,256435,51301,4588,64409,84002,51146,79369,374378,93010,6484,442117,84752,51809,192134,200958,55568,374907,2591,4589,56913,118430,727897,27090,114805,94025,2590,6482,9245,63917,79695,8693,394263,9331,3742	GALNT1,CHST4,GALNT5,GALNT15,GALNT8,MUC12,GALNT14,B3GNT3,GALNTL5,GALNT9,B3GNTL1,MUC15,GCNT1,MUC2,GALNT16,MUC13,ST3GAL3,GALNT6,ST3GAL2,ST6GALNAC2,GCNT7,MUC4,MUC17,B4GALT5,B3GNT2,ST6GAL1,ST6GALNAC3,GCNT4,MUC6,GALNT17,B3GNT5,A4GNT,B3GNT4,GALNT18,B3GNT7,ST3GAL4,GALNTL6,B3GNT9,GALNT7,B3GNT6,MUC20,GALNT10,B3GNT8,GALNT3,MUC7,C1GALT1,MUCL1,MUC5B,ST6GALNAC4,GALNT13,MUC16,GALNT2,ST3GAL1,GCNT3,GALNT11,GALNT12,GALNT4,MUC21,B4GALT6,KCNA6
R-HSA-168928	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways	0.182788236085866	-1.69942697604895	84	77	0.00852335620987381	9034	10285	29110,7314,7706,3441,9474,9246,4214,3445,5300,9641,7323,843,100302237,4791,6288,3448,54476,84282,7189,7321,5094,3659,79671,4793,3456,1387,170506,3551,4790,1540,9140,841,100500827,54941,3093,3443,51191,83737,6283,10010,3439,79132,3440,7318,3452,26007,4615,7316,1660,100847079,7311,3444,3660,2033,8772,64135,8737,9636,351,7322,3146,23586,6233,3665,4792,80143,3661,84166,7187,8887,57506,1147,7128,177,3442,5970,3449	TBK1,UBB,TRIM25,IFNA4,ATG5,UBE2L6,MAP3K1,IFNA8,PIN1,IKBKE,UBE2D3,CASP10,MIR1281,NFKB2,SAA1,IFNA14,RNF216,RNF135,TRAF6,UBE2D1,PCBP2,IRF1,NLRX1,NFKBIB,IFNB1,CREBBP,DHX36,IKBKB,NFKB1,CYLD,ATG12,CASP8,MIR3614,RNF125,UBE2K,IFNA6,HERC5,ITCH,S100A12,TANK,IFNA1,DHX58,IFNA2,UBA7,IFNA21,TKFC,MYD88,UBC,DHX9,MIR5193,UBA52,IFNA7,IRF2,EP300,FADD,IFIH1,RIPK1,ISG15,APP,UBE2D2,HMGB1,RIGI,RPS27A,IRF7,NFKBIA,SIKE1,IRF3,NLRC5,TRAF3,TAX1BP1,MAVS,CHUK,TNFAIP3,AGER,IFNA5,RELA,IFNA16
R-HSA-2514859	Inactivation, recovery and regulation of the phototransduction cascade	0.183856033772595	-1.6936022527764	35	33	0.00365286694708878	9034	10285	10988,5158,131890,9397,6295,5588,2978,2779,1259,2792,6011,388531,808,79823,3000,5145,4836,6010,5578,10681,5957,801,8787,9626,2342,2868,2782,23173,805,2979,2339,5148,1258	METAP2,PDE6B,GRK7,NMT2,SAG,PRKCQ,GUCA1A,GNAT1,CNGA1,GNGT1,GRK1,RGS9BP,CALM3,CAMKMT,GUCY2D,PDE6A,NMT1,RHO,PRKCA,GNB5,RCVRN,CALM1,RGS9,GUCA1C,FNTB,GRK4,GNB1,METAP1,CALM2,GUCA1B,FNTA,PDE6G,CNGB1
R-HSA-5607763	CLEC7A (Dectin-1) induces NFAT activation	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	3708,801,4772,10768,3709,4773,4775,5534,805,808,5532,3710,5530	ITPR1,CALM1,NFATC1,AHCYL1,ITPR2,NFATC2,NFATC3,PPP3R1,CALM2,CALM3,PPP3CB,ITPR3,PPP3CA
R-HSA-211227	Activation of DNA fragmentation factor	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	3008,3024,3146,1677,1676,836,3836,3837,3005,3007,3148,3009,3006	H1-4,H1-1,HMGB1,DFFB,DFFA,CASP3,KPNA1,KPNB1,H1-0,H1-3,HMGB2,H1-5,H1-2
R-HSA-5140745	WNT5A-dependent internalization of FZD2, FZD5 and ROR2	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	1175,163,161,7474,7855,1213,2535,1212,4920,160,1211,1173,4919	AP2S1,AP2B1,AP2A2,WNT5A,FZD5,CLTC,FZD2,CLTB,ROR2,AP2A1,CLTA,AP2M1,ROR1
R-HSA-391160	Signal regulatory protein (SIRP) family interactions	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	140885,5777,961,10326,5781,55423,7305,6714,8935,2885,5747,2533,2185	SIRPA,PTPN6,CD47,SIRPB1,PTPN11,SIRPG,TYROBP,SRC,SKAP2,GRB2,PTK2,FYB1,PTK2B
R-HSA-5210891	Uptake and function of anthrax toxins	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	805,118429,6416,84168,5608,808,5604,5609,5606,801,10015,5045,5605	CALM2,ANTXR2,MAP2K4,ANTXR1,MAP2K6,CALM3,MAP2K1,MAP2K7,MAP2K3,CALM1,PDCD6IP,FURIN,MAP2K2
R-HSA-140342	Apoptosis induced DNA fragmentation	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	3007,3148,3006,3009,3005,3836,3837,836,1677,1676,3008,3024,3146	H1-3,HMGB2,H1-2,H1-5,H1-0,KPNA1,KPNB1,CASP3,DFFB,DFFA,H1-4,H1-1,HMGB1
R-HSA-71240	Tryptophan catabolism	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	3620,6999,23498,8942,883,56267,8564,125061,169355,51166,6520,8140,130013	IDO1,TDO2,HAAO,KYNU,KYAT1,KYAT3,KMO,AFMID,IDO2,AADAT,SLC3A2,SLC7A5,ACMSD
R-HSA-425561	Sodium/Calcium exchangers	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	80024,6717,6543,801,123041,9187,6546,25769,808,805,57419,283652,6547	SLC8B1,SRI,SLC8A2,CALM1,SLC24A4,SLC24A1,SLC8A1,SLC24A2,CALM3,CALM2,SLC24A3,SLC24A5,SLC8A3
R-HSA-8847993	ERBB2 Activates PTK6 Signaling	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	685,2065,1956,1950,1839,9542,5753,2069,2066,2064,145957,10718,3084	BTC,ERBB3,EGFR,EGF,HBEGF,NRG2,PTK6,EREG,ERBB4,ERBB2,NRG4,NRG3,NRG1
R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	25946,890,9134,1820,1869,1027,7157,1026,898,1017,8900,57060,144455	ZNF385A,CCNA2,CCNE2,ARID3A,E2F1,CDKN1B,TP53,CDKN1A,CCNE1,CDK2,CCNA1,PCBP4,E2F7
R-HSA-171007	p38MAPK events	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	5898,5899,3845,1432,6300,6714,9261,3265,5600,5603,5900,4893,7867	RALA,RALB,KRAS,MAPK14,MAPK12,SRC,MAPKAPK2,HRAS,MAPK11,MAPK13,RALGDS,NRAS,MAPKAPK3
R-HSA-5626467	RHO GTPases activate IQGAPs	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	5879,801,128239,6249,10788,1499,4221,8826,805,998,808,999,1495	RAC1,CALM1,IQGAP3,CLIP1,IQGAP2,CTNNB1,MEN1,IQGAP1,CALM2,CDC42,CALM3,CDH1,CTNNA1
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	9542,6233,7314,7316,9101,2065,10000,3084,208,207,7311,2064,10193	NRG2,RPS27A,UBB,UBC,USP8,ERBB3,AKT3,NRG1,AKT2,AKT1,UBA52,ERBB2,RNF41
R-HSA-75205	Dissolution of Fibrin Clot	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	5054,302,5270,6281,5345,5328,5329,5269,5340,5327,5271,3273,5055	SERPINE1,ANXA2,SERPINE2,S100A10,SERPINF2,PLAU,PLAUR,SERPINB6,PLG,PLAT,SERPINB8,HRG,SERPINB2
R-HSA-5658623	FGFRL1 modulation of FGFR1 signaling	0.185066915068888	-1.68703781622753	13	13	0.0014390081912774	9034	10285	8822,8817,2250,2247,161742,2253,8074,53834,2248,27006,2255,2249,200734	FGF17,FGF18,FGF5,FGF2,SPRED1,FGF8,FGF23,FGFRL1,FGF3,FGF22,FGF10,FGF4,SPRED2
R-HSA-210500	Glutamate Neurotransmitter Release Cycle	0.191992234686694	-1.65030035211239	24	23	0.00254593756918309	9034	10285	6512,8500,8541,57030,27165,6812,22999,6844,2744,9256,10497,6616,8499,10550,54407,5864,6507,6505,8497,10815,6857,6506,6511	SLC1A7,PPFIA1,PPFIA3,SLC17A7,GLS2,STXBP1,RIMS1,VAMP2,GLS,TSPOAP1,UNC13B,SNAP25,PPFIA2,ARL6IP5,SLC38A2,RAB3A,SLC1A3,SLC1A1,PPFIA4,CPLX1,SYT1,SLC1A2,SLC1A6
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	0.191992234686694	-1.65030035211239	24	23	0.00254593756918309	9034	10285	2977,10335,4842,5593,5592,3779,5139,2982,2983,8654,5140,5152,4846,3708,3778,27345,5153,10242,27094,5136,50940,10846,5138	GUCY1A2,IRAG1,NOS1,PRKG2,PRKG1,KCNMB1,PDE3A,GUCY1A1,GUCY1B1,PDE5A,PDE3B,PDE9A,NOS3,ITPR1,KCNMA1,KCNMB4,PDE1B,KCNMB2,KCNMB3,PDE1A,PDE11A,PDE10A,PDE2A
R-HSA-171052	LDL-mediated lipid transport	0.191992234686694	-1.65030035211239	24	23	0.00254593756918309	9034	10285	3949,1173,10577,160,8435,23491,319,161,1213,100616211,255738,6646,1211,26119,338,1071,3988,51599,4864,4018,57552,163,1175	LDLR,AP2M1,NPC2,AP2A1,SOAT2,CES3,APOF,AP2A2,CLTC,MIR4709,PCSK9,SOAT1,CLTA,LDLRAP1,APOB,CETP,LIPA,LSR,NPC1,LPA,NCEH1,AP2B1,AP2S1
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	0.191992234686694	-1.65030035211239	24	23	0.00254593756918309	9034	10285	6256,1646,1109,1582,6718,6342,5740,23600,1645,80270,1593,9971,8647,10005,11001,8648,570,8644,1581,9420,10499,8309,3295	RXRA,AKR1C2,AKR1C4,CYP8B1,AKR1D1,SCP2,PTGIS,AMACR,AKR1C1,HSD3B7,CYP27A1,NR1H4,ABCB11,ACOT8,SLC27A2,NCOA1,BAAT,AKR1C3,CYP7A1,CYP7B1,NCOA2,ACOX2,HSD17B4
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse	0.191992234686694	-1.65030035211239	24	23	0.00254593756918309	9034	10285	4627,27289,10398,9826,2064,4637,5879,388,4628,3985,9475,998,23365,5364,79784,5880,4629,10507,3984,389,103910,391,387	MYH9,RND1,MYL9,ARHGEF11,ERBB2,MYL6,RAC1,RHOB,MYH10,LIMK2,ROCK2,CDC42,ARHGEF12,PLXNB1,MYH14,RAC2,MYH11,SEMA4D,LIMK1,RHOC,MYL12B,RHOG,RHOA
R-HSA-156588	Glucuronidation	0.191992234686694	-1.65030035211239	24	23	0.00254593756918309	9034	10285	54576,7364,7366,167127,133688,54600,54659,54578,7365,54577,54490,10941,54579,54658,7363,55347,7360,10720,79799,54657,7358,574537,23169	UGT1A8,UGT2B7,UGT2B15,UGT3A2,UGT3A1,UGT1A9,UGT1A3,UGT1A6,UGT2B10,UGT1A7,UGT2B28,UGT2A1,UGT1A5,UGT1A1,UGT2B4,ABHD10,UGP2,UGT2B11,UGT2A3,UGT1A4,UGDH,UGT2A2,SLC35D1
R-HSA-201451	Signaling by BMP	0.191992234686694	-1.65030035211239	24	23	0.00254593756918309	9034	10285	64750,406975,7321,657,659,650,93,4093,4090,4092,11167,92,4086,9765,4091,658,64388,57154,9241,6497,7323,9350,4089	SMURF2,MIR198,UBE2D1,BMPR1A,BMPR2,BMP2,ACVR2B,SMAD9,SMAD5,SMAD7,FSTL1,ACVR2A,SMAD1,ZFYVE16,SMAD6,BMPR1B,GREM2,SMURF1,NOG,SKI,UBE2D3,CER1,SMAD4
R-HSA-6785807	Interleukin-4 and 13 signaling	0.192557228845335	-1.64736187673398	111	101	0.0111799867168475	9034	10285	246,9655,6657,1026,356,7124,5295,3596,3576,207,2309,3684,100616340,3312,6778,5008,8651,6935,2353,3718,3553,3570,3586,3565,3605,2208,7133,7040,3689,3606,3566,1052,301,1901,100500842,3688,4312,2625,6097,3911,3726,6095,7422,595,6774,1278,3082,948,6367,3592,7291,9021,4988,5451,5443,5292,2308,4170,4609,4313,3976,5743,2162,3593,3320,3662,6288,3716,3934,3383,7412,58480,4318,3162,3717,332,3091,112744,3687,6356,604,2247,2335,4692,3929,3569,6347,149233,79923,3552,596,4985,6772,7431,240,4314,7157,598,6624,7297,10538	ALOX15,SOCS5,SOX2,CDKN1A,FASLG,TNF,PIK3R1,IL13,CXCL8,AKT1,FOXO3,ITGAM,MIR4758,HSPA8,STAT6,OSM,SOCS1,ZEB1,FOS,JAK3,IL1B,IL6R,IL10,IL4,IL17A,FCER2,TNFRSF1B,TGFB1,ITGB2,IL18,IL4R,CEBPD,ANXA1,S1PR1,MIR3652,ITGB1,MMP1,GATA3,RORC,LAMA5,JUNB,RORA,VEGFA,CCND1,STAT3,COL1A2,HGF,CD36,CCL22,IL12A,TWIST1,SOCS3,OPRM1,POU2F1,POMC,PIM1,FOXO1,MCL1,MYC,MMP2,LIF,PTGS2,F13A1,IL12B,HSP90AA1,IRF4,SAA1,JAK1,LCN2,ICAM1,VCAM1,RHOU,MMP9,HMOX1,JAK2,BIRC5,HIF1A,IL17F,ITGAX,CCL11,BCL6,FGF2,FN1,NDN,LBP,IL6,CCL2,IL23R,NANOG,IL1A,BCL2,OPRD1,STAT1,VIM,ALOX5,MMP3,TP53,BCL2L1,FSCN1,TYK2,BATF
R-HSA-114604	GPVI-mediated activation cascade	0.19747846970209	-1.62212571475007	54	50	0.00553464688952845	9034	10285	5879,27040,3560,5296,388,5777,8503,3932,5291,3558,1439,207,23533,6464,5295,5293,10000,5170,3568,5781,7409,387,5290,3717,2885,3718,5336,2534,10451,2207,3567,208,3716,9846,5294,51266,3562,5590,10630,6850,4067,3937,51206,5880,1437,391,998,7410,146850,3559	RAC1,LAT,IL2RB,PIK3R2,RHOB,PTPN6,PIK3R3,LCK,PIK3CB,IL2,CSF2RB,AKT1,PIK3R5,SHC1,PIK3R1,PIK3CD,AKT3,PDPK1,IL5RA,PTPN11,VAV1,RHOA,PIK3CA,JAK2,GRB2,JAK3,PLCG2,FYN,VAV3,FCER1G,IL5,AKT2,JAK1,GAB2,PIK3CG,CLEC1B,IL3,PRKCZ,PDPN,SYK,LYN,LCP2,GP6,RAC2,CSF2,RHOG,CDC42,VAV2,PIK3R6,IL2RA
R-HSA-390522	Striated Muscle Contraction	0.199777589436555	-1.61055058404085	34	32	0.00354217400929821	9034	10285	4607,29766,4632,89,8557,29765,7111,4633,7431,4606,7169,1674,7139,88,7171,7140,29767,4604,7273,7135,7170,4634,4621,4635,4626,7136,7125,7138,4703,7134,4624,7168	MYBPC3,TMOD3,MYL1,ACTN3,TCAP,TMOD4,TMOD1,MYL2,VIM,MYBPC2,TPM2,DES,TNNT2,ACTN2,TPM4,TNNT3,TMOD2,MYBPC1,TTN,TNNI1,TPM3,MYL3,MYH3,MYL4,MYH8,TNNI2,TNNC2,TNNT1,NEB,TNNC1,MYH6,TPM1
R-HSA-113510	E2F mediated regulation of DNA replication	0.199777589436555	-1.61055058404085	34	32	0.00354217400929821	9034	10285	1719,7084,5001,23649,8900,5519,8318,990,891,5111,7027,4998,1869,5925,84515,5557,5516,7029,5518,7298,6241,983,23594,23595,4999,5515,81620,5558,898,26271,5000,993	DHFR,TK2,ORC5,POLA2,CCNA1,PPP2R1B,CDC45,CDC6,CCNB1,PCNA,TFDP1,ORC1,E2F1,RB1,MCM8,PRIM1,PPP2CB,TFDP2,PPP2R1A,TYMS,RRM2,CDK1,ORC6,ORC3,ORC2,PPP2CA,CDT1,PRIM2,CCNE1,FBXO5,ORC4,CDC25A
R-HSA-5654727	Negative regulation of FGFR2 signaling	0.199777589436555	-1.61055058404085	34	32	0.00354217400929821	9034	10285	2247,8074,2253,2250,2252,6233,673,10253,2246,2248,6714,5594,5781,7316,2254,7314,867,5515,8822,8817,2263,2885,5518,2249,2251,26281,7311,2255,27006,10818,5595,5516	FGF2,FGF23,FGF8,FGF5,FGF7,RPS27A,BRAF,SPRY2,FGF1,FGF3,SRC,MAPK1,PTPN11,UBC,FGF9,UBB,CBL,PPP2CA,FGF17,FGF18,FGFR2,GRB2,PPP2R1A,FGF4,FGF6,FGF20,UBA52,FGF10,FGF22,FRS2,MAPK3,PPP2CB
R-HSA-5694530	Cargo concentration in the ER	0.199777589436555	-1.61055058404085	34	32	0.00354217400929821	9034	10285	10484,375056,374,10113,5265,2890,1075,9871,10959,7039,100313843,79748,254263,9554,1294,6811,2153,3998,966,10972,51128,10960,10802,4253,1522,149111,10175,2348,9632,10427,90411,9570	SEC23A,MIA3,AREG,PREB,SERPINA1,GRIA1,CTSC,SEC24D,TMED2,TGFA,MIR711,LMAN1L,CNIH2,SEC22B,COL7A1,STX5,F5,LMAN1,CD59,TMED10,SAR1B,LMAN2,SEC24A,MIA2,CTSZ,CNIH3,CNIH1,FOLR1,SEC24C,SEC24B,MCFD2,GOSR2
R-HSA-5610787	Hedgehog 'off' state	0.199878874069152	-1.61004372555606	101	92	0.0101837502767323	9034	10285	23198,7979,7316,8100,112,5710,143471,122706,114,5692,10197,9491,5701,55764,5573,115,54903,6608,51098,8945,27152,5708,9861,5568,5682,5715,23322,5717,108,5687,5685,57539,8650,5690,113,11127,5686,8454,5695,55081,374654,109,57728,107,5704,51684,6500,5696,83737,5713,9978,1452,5576,5684,2778,7311,5699,80199,5577,5575,5700,55811,196883,5718,5567,6233,5707,5711,5694,5566,9742,26160,5706,23432,79659,7314,5727,5719,5693,7289,5702,79809,5714,5691,2932,2736,5698,111,2737,2735,10213,5720	PSME4,SEM1,UBC,IFT88,ADCY6,PSMD4,PSMA8,PSMB11,ADCY8,PSMB4,PSME3,PSMF1,PSMC2,IFT122,PRKAR1A,ADCY9,MKS1,SMO,IFT52,BTRC,INTU,PSMD2,PSMD6,PRKACG,PSMA1,PSMD9,RPGRIP1L,PSMD11,ADCY2,PSMA6,PSMA4,WDR35,NUMB,PSMB2,ADCY7,KIF3A,PSMA5,CUL1,PSMB7,IFT57,KIF7,ADCY3,WDR19,ADCY1,PSMC4,SUFU,SKP1,PSMB8,ITCH,PSMD7,RBX1,CSNK1A1,PRKAR2A,PSMA3,GNAS,UBA52,PSMB10,FUZ,PRKAR2B,PRKAR1B,PSMC1,ADCY10,ADCY4,PSMD12,PRKACB,RPS27A,PSMD1,PSMD5,PSMB6,PRKACA,IFT140,IFT172,PSMC6,GPR161,DYNC2H1,UBB,PTCH1,PSMD13,PSMB5,TULP3,PSMC3,TTC21B,PSMD8,PSMB3,GSK3B,GLI2,PSMB9,ADCY5,GLI3,GLI1,PSMD14,PSME1
R-HSA-2187338	Visual phototransduction	0.199878874069152	-1.61004372555606	101	92	0.0101837502767323	9034	10285	9249,9397,145226,131890,10988,2817,375790,5947,8608,64220,1109,5950,6385,29967,8644,5957,4023,222236,2979,805,337,4647,6295,10170,3292,6017,6382,2978,2779,388531,24,348,6010,338,5145,53630,8787,9626,3339,2262,336,55937,2339,157506,151056,8630,285440,5588,1645,5948,3949,808,79823,3000,6383,121214,9672,5578,7276,2342,51109,611,1258,23173,344,335,4036,5158,4035,7804,1259,2792,10082,50700,6011,5959,9187,4836,5949,26020,6121,9227,10681,801,57016,338328,2868,2782,5406,1208,345,5148	DHRS3,NMT2,RDH12,GRK7,METAP2,GPC1,AGRN,RBP1,RDH16,STRA6,AKR1C4,RBP4,SDC4,LRP12,AKR1C3,RCVRN,LPL,NAPEPLD,GUCA1B,CALM2,APOA4,MYO7A,SAG,DHRS9,HSD17B1,RLBP1,SDC1,GUCA1A,GNAT1,RGS9BP,ABCA4,APOE,RHO,APOB,PDE6A,BCO1,RGS9,GUCA1C,HSPG2,GPC5,APOA2,APOM,FNTA,RDH10,PLB1,HSD17B6,CYP4V2,PRKCQ,AKR1C1,RBP2,LDLR,CALM3,CAMKMT,GUCY2D,SDC2,SDR9C7,SDC3,PRKCA,TTR,FNTB,RDH11,OPN1SW,CNGB1,METAP1,APOC2,APOA1,LRP2,PDE6B,LRP1,LRP8,CNGA1,GNGT1,GPC6,RDH8,GRK1,RDH5,SLC24A1,NMT1,RBP3,LRP10,RPE65,LRAT,GNB5,CALM1,AKR1B10,GPIHBP1,GRK4,GNB1,PNLIP,CLPS,APOC3,PDE6G
R-HSA-209822	Glycoprotein hormones	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	3972,94115,3624,3623,3626,1081,83729,2488,1082,7252,93659,3625	LHB,CGB8,INHBA,INHA,INHBC,CGA,INHBE,FSHB,CGB3,TSHB,CGB5,INHBB
R-HSA-1236977	Endosomal/Vacuolar pathway	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	1520,1515,3135,3106,4012,3134,3133,1514,3105,3136,3107,567	CTSS,CTSV,HLA-G,HLA-B,LNPEP,HLA-F,HLA-E,CTSL,HLA-A,HLA-H,HLA-C,B2M
R-HSA-1296346	Tandem pore domain potassium channels	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	50801,3776,9424,54207,83795,3777,51305,338567,10089,3775,56659,89822	KCNK4,KCNK2,KCNK6,KCNK10,KCNK16,KCNK3,KCNK9,KCNK18,KCNK7,KCNK1,KCNK13,KCNK17
R-HSA-8851680	Butyrophilin (BTN) family interactions	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	11119,56244,30835,79908,11120,5493,11118,153579,696,7498,10385,10384	BTN3A1,BTNL2,CD209,BTNL8,BTN2A1,PPL,BTN3A2,BTNL9,BTN1A1,XDH,BTN2A2,BTN3A3
R-HSA-71064	Lysine catabolism	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	10157,2639,123688,501,4967,1428,89874,85007,1743,1738,51166,51268	AASS,GCDH,HYKK,ALDH7A1,OGDH,CRYM,SLC25A21,PHYKPL,DLST,DLD,AADAT,PIPOX
R-HSA-210990	PECAM1 interactions	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	3932,2534,5175,6714,4067,3685,5335,5781,3690,3635,7525,5777	LCK,FYN,PECAM1,SRC,LYN,ITGAV,PLCG1,PTPN11,ITGB3,INPP5D,YES1,PTPN6
R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	3614,122622,8833,64077,5198,3615,471,158,10606,2618,5471,159	IMPDH1,ADSS1,GMPS,LHPP,PFAS,IMPDH2,ATIC,ADSL,PAICS,GART,PPAT,ADSS2
R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	58484,843,7161,472,839,8626,835,317,8738,834,7157,55367	NLRC4,CASP10,TP73,ATM,CASP6,TP63,CASP2,APAF1,CRADD,CASP1,TP53,PIDD1
R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	8797,23368,7159,8795,7157,355,8626,3486,7161,124446,8793,8794	TNFRSF10A,PPP1R13B,TP53BP2,TNFRSF10B,TP53,FAS,TP63,IGFBP3,TP73,TMEM219,TNFRSF10D,TNFRSF10C
R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	768,64344,100302237,2033,2034,1387,405,10370,2056,25994,7422,3091	CA9,HIF3A,MIR1281,EP300,EPAS1,CREBBP,ARNT,CITED2,EPO,HIGD1A,VEGFA,HIF1A
R-HSA-4641265	Repression of WNT target genes	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	1487,83439,6932,7088,6934,7089,3065,7090,7091,51176,1488,166	CTBP1,TCF7L1,TCF7,TLE1,TCF7L2,TLE2,HDAC1,TLE3,TLE4,LEF1,CTBP2,TLE5
R-HSA-8866427	VLDLR internalisation and degradation	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	163,161,1213,1175,7376,160,1211,1173,255738,10062,29116,7436	AP2B1,AP2A2,CLTC,AP2S1,NR1H2,AP2A1,CLTA,AP2M1,PCSK9,NR1H3,MYLIP,VLDLR
R-HSA-71384	Ethanol oxidation	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	84532,126,217,219,124,131,125,127,128,55902,130,216	ACSS1,ADH1C,ALDH2,ALDH1B1,ADH1A,ADH7,ADH1B,ADH4,ADH5,ACSS2,ADH6,ALDH1A1
R-HSA-622323	Presynaptic nicotinic acetylcholine receptors	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	1143,1144,1136,1134,1146,1142,1138,1135,1141,1137,8973,1145	CHRNB4,CHRND,CHRNA3,CHRNA1,CHRNG,CHRNB3,CHRNA5,CHRNA2,CHRNB2,CHRNA4,CHRNA6,CHRNE
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	7533,7534,7532,10971,7465,995,2810,983,891,7531,7529,1111	YWHAH,YWHAZ,YWHAG,YWHAQ,WEE1,CDC25C,SFN,CDK1,CCNB1,YWHAE,YWHAB,CHEK1
R-HSA-5578768	Physiological factors	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	4882,4880,6910,25937,204851,2626,4878,1482,8850,4881,10699,28996	NPR2,NPPC,TBX5,WWTR1,HIPK1,GATA4,NPPA,NKX2-5,KAT2B,NPR1,CORIN,HIPK2
R-HSA-844456	The NLRP3 inflammasome	0.210728487976568	-1.55718476096808	12	12	0.00132831525348683	9034	10285	351,9051,5027,29108,114548,4210,3326,10628,24145,10910,7295,834	APP,PSTPIP1,P2RX7,PYCARD,NLRP3,MEFV,HSP90AB1,TXNIP,PANX1,SUGT1,TXN,CASP1
R-HSA-191859	snRNP Assembly	0.21104303786975	-1.55569319535863	53	49	0.00542395395173788	9034	10285	4686,53371,9972,23225,23511,10419,22916,23279,79833,23165,100101267,5903,9818,96764,1207,6628,11097,9688,55706,79023,11218,55746,6606,57122,8487,79902,348995,6607,10762,23636,6633,7175,4928,6637,6635,129401,50628,79084,9631,81929,25929,8086,6636,8021,10073,79760,9883,51808,4927	NCBP1,NUP54,NUP153,NUP210,NUP188,PRMT5,NCBP2,NUP160,GEMIN6,NUP205,POM121C,RANBP2,NUP58,TGS1,CLNS1A,SNRPB,NUP42,NUP93,NDC1,NUP37,DDX20,NUP133,SMN1,NUP107,GEMIN2,NUP85,NUP43,SMN2,NUP50,NUP62,SNRPD2,TPR,NUP98,SNRPG,SNRPE,NUP35,GEMIN4,WDR77,NUP155,SEH1L,GEMIN5,AAAS,SNRPF,NUP214,SNUPN,GEMIN7,POM121,PHAX,NUP88
R-HSA-194441	Metabolism of non-coding RNA	0.21104303786975	-1.55569319535863	53	49	0.00542395395173788	9034	10285	4686,53371,9972,23225,10419,23511,22916,23279,79833,100101267,23165,5903,9818,1207,96764,11097,6628,55706,9688,79023,11218,55746,6606,8487,57122,79902,348995,6607,10762,23636,6633,4928,6637,7175,129401,6635,79084,50628,25929,81929,9631,8086,6636,9883,51808,8021,10073,79760,4927	NCBP1,NUP54,NUP153,NUP210,PRMT5,NUP188,NCBP2,NUP160,GEMIN6,POM121C,NUP205,RANBP2,NUP58,CLNS1A,TGS1,NUP42,SNRPB,NDC1,NUP93,NUP37,DDX20,NUP133,SMN1,GEMIN2,NUP107,NUP85,NUP43,SMN2,NUP50,NUP62,SNRPD2,NUP98,SNRPG,TPR,NUP35,SNRPE,WDR77,GEMIN4,GEMIN5,SEH1L,NUP155,AAAS,SNRPF,POM121,PHAX,NUP214,SNUPN,GEMIN7,NUP88
R-HSA-428930	Thromboxane signalling through TP receptor	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	51764,54331,6915,55970,2787,2769,10681,59345,94235,2791,2776,2790,2792,2782,2786,10672,2767,2788,2784,2783,2793,9630	GNG13,GNG2,TBXA2R,GNG12,GNG5,GNA15,GNB5,GNB4,GNG8,GNG11,GNAQ,GNG10,GNGT1,GNB1,GNG4,GNA13,GNA11,GNG7,GNB3,GNB2,GNGT2,GNA14
R-HSA-5205647	Mitophagy	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	9140,9868,51001,6233,401505,9927,84557,65018,5071,55669,7416,7316,54543,8878,56993,9474,7314,10452,100188893,9804,81631,7311	ATG12,TOMM70,MTERF3,RPS27A,TOMM5,MFN2,MAP1LC3A,PINK1,PRKN,MFN1,VDAC1,UBC,TOMM7,SQSTM1,TOMM22,ATG5,UBB,TOMM40,TOMM6,TOMM20,MAP1LC3B,UBA52
R-HSA-5654695	PI-3K cascade:FGFR2	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	5295,10818,2255,27006,2248,26281,2251,2249,2549,2246,2885,2263,5290,8817,8822,2250,2252,8074,2254,2253,2247,5781	PIK3R1,FRS2,FGF10,FGF22,FGF3,FGF20,FGF6,FGF4,GAB1,FGF1,GRB2,FGFR2,PIK3CA,FGF18,FGF17,FGF5,FGF7,FGF23,FGF9,FGF8,FGF2,PTPN11
R-HSA-5205685	Pink/Parkin Mediated Mitophagy	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	56993,9474,7314,7316,54543,8878,7311,81631,100188893,10452,9804,51001,6233,9868,9140,65018,84557,9927,7416,5071,55669,401505	TOMM22,ATG5,UBB,UBC,TOMM7,SQSTM1,UBA52,MAP1LC3B,TOMM6,TOMM40,TOMM20,MTERF3,RPS27A,TOMM70,ATG12,PINK1,MAP1LC3A,MFN2,VDAC1,PRKN,MFN1,TOMM5
R-HSA-112409	RAF-independent MAPK1/3 activation	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	1846,7297,3717,80824,5594,1844,5781,1848,1847,3572,3570,5595,3716,983,1850,3569,5605,1849,1843,11221,8682,5604	DUSP4,TYK2,JAK2,DUSP16,MAPK1,DUSP2,PTPN11,DUSP6,DUSP5,IL6ST,IL6R,MAPK3,JAK1,CDK1,DUSP8,IL6,MAP2K2,DUSP7,DUSP1,DUSP10,PEA15,MAP2K1
R-HSA-392170	ADP signalling through P2Y purinoceptor 12	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	2782,2783,51764,10681,406974,2791,2771,59345,2792,2770,2790,2786,2788,2784,2773,2793,54331,64805,2787,55970,346562,94235	GNB1,GNB2,GNG13,GNB5,MIR197,GNG11,GNAI2,GNB4,GNGT1,GNAI1,GNG10,GNG4,GNG7,GNB3,GNAI3,GNGT2,GNG2,P2RY12,GNG5,GNG12,GNAT3,GNG8
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	3065,5494,142,4088,7050,9612,6497,7311,7323,54778,4089,64750,7316,7314,6233,7321,23327,9611,6498,51592,60436,4087	HDAC1,PPM1A,PARP1,SMAD3,TGIF1,NCOR2,SKI,UBA52,UBE2D3,RNF111,SMAD4,SMURF2,UBC,UBB,RPS27A,UBE2D1,NEDD4L,NCOR1,SKIL,TRIM33,TGIF2,SMAD2
R-HSA-5365859	RA biosynthesis pathway	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	124,1592,10901,51109,126,157506,216,8644,8854,56603,112724,8608,220,728635,5959,195814,9249,1381,64577,127,57665,10170	ADH1A,CYP26A1,DHRS4,RDH11,ADH1C,RDH10,ALDH1A1,AKR1C3,ALDH1A2,CYP26B1,RDH13,RDH16,ALDH1A3,DHRS4L1,RDH5,SDR16C5,DHRS3,CRABP1,ALDH8A1,ADH4,RDH14,DHRS9
R-HSA-5654699	SHC-mediated cascade:FGFR2	0.211621473354763	-1.55295610326421	23	22	0.00243524463139252	9034	10285	2251,2246,2249,4893,2885,2263,6464,3845,2255,27006,26281,3265,2248,2254,2253,8074,2247,8817,8822,6654,2252,2250	FGF6,FGF1,FGF4,NRAS,GRB2,FGFR2,SHC1,KRAS,FGF10,FGF22,FGF20,HRAS,FGF3,FGF9,FGF8,FGF23,FGF2,FGF18,FGF17,SOS1,FGF7,FGF5
R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	0.213767653803092	-1.54286558368405	127	115	0.0127296878459154	9034	10285	112950,1579,10025,133522,1374,80306,5244,948,2033,9443,9971,9477,9439,406,3156,8463,57491,9575,54797,7005,23179,3157,2168,5465,23389,25937,23054,4199,183,9412,9611,6095,376497,9441,29079,85441,9969,336,123,57761,96764,80205,1581,8202,8648,9572,50486,19,196,4862,8800,4801,26230,34,6720,10413,10001,23097,7296,219541,27242,84246,4802,9440,51003,23309,51586,400569,10499,79718,3992,892,2180,1024,116519,11010,7003,10891,4520,29841,9967,8841,81857,405,5468,90390,6721,6822,55090,9442,4899,100302237,4800,7004,2101,51129,1376,9612,5469,2222,1490,9915,25942,27063,2274,6667,10498,54600,6256,51,1543,211,335,6604,1387	MED8,CYP4A11,MED16,PPARGC1B,CPT1A,MED28,ABCB4,CD36,EP300,MED7,NR1H4,MED20,MED23,BMAL1,HMGCR,TEAD2,AHRR,CLOCK,MED18,TEAD3,RGL1,HMGCS1,FABP1,PPARA,MED13L,WWTR1,NCOA6,ME1,AGT,MED21,NCOR1,RORA,SLC27A1,MED26,MED4,HELZ2,MED13,APOA2,PLIN2,TRIB3,TGS1,CHD9,CYP7A1,NCOA3,NCOA1,NR1D1,G0S2,ABCA1,AHR,NPAS2,PEX11A,NFYB,TIAM2,ACADM,SREBF1,YAP1,MED6,CDK19,TXNRD1,MED19,TNFRSF21,MED10,NFYC,MED17,MED31,SIN3B,MED15,MED11,NCOA2,TBL1XR1,FADS1,CCNC,ACSL1,CDK8,APOA5,GLIPR1,TEAD1,PPARGC1A,MTF1,GRHL1,THRAP3,HDAC3,MED25,ARNT,PPARG,MED30,SREBF2,SULT2A1,MED9,MED27,NRF1,MIR1281,NFYA,TEAD4,ESRRA,ANGPTL4,CPT2,NCOR2,MED1,FDFT1,CCN2,ARNT2,SIN3A,ANKRD1,FHL2,SP1,CARM1,UGT1A9,RXRA,ACOX1,CYP1A1,ALAS1,APOA1,SMARCD3,CREBBP
R-HSA-375280	Amine ligand-binding receptors	0.215315594628249	-1.53565044514828	43	40	0.00442771751162276	9034	10285	3354,59340,319100,9288,83551,1129,147,3274,3356,151,3351,1133,3363,1813,11255,3269,9038,3362,3360,9287,1812,3357,1132,155,3355,150,154,1128,1131,3361,134864,1815,148,153,3352,3350,1814,146,1816,152	HTR1E,HRH4,TAAR6,TAAR3P,TAAR8,CHRM2,ADRA1B,HRH2,HTR2A,ADRA2B,HTR1B,CHRM5,HTR7,DRD2,HRH3,HRH1,TAAR5,HTR6,HTR4,TAAR2,DRD1,HTR2B,CHRM4,ADRB3,HTR1F,ADRA2A,ADRB2,CHRM1,CHRM3,HTR5A,TAAR1,DRD4,ADRA1A,ADRB1,HTR1D,HTR1A,DRD3,ADRA1D,DRD5,ADRA2C
R-HSA-5654726	Negative regulation of FGFR1 signaling	0.216839809702201	-1.52859640218584	33	31	0.00343148107150764	9034	10285	2248,6714,2246,10253,2250,6233,673,2247,2253,8074,26281,27006,2255,9365,7311,5595,10818,5516,2260,5518,2885,2249,2251,7314,5515,867,8822,5594,7316,5781,2254	FGF3,SRC,FGF1,SPRY2,FGF5,RPS27A,BRAF,FGF2,FGF8,FGF23,FGF20,FGF22,FGF10,KL,UBA52,MAPK3,FRS2,PPP2CB,FGFR1,PPP2R1A,GRB2,FGF4,FGF6,UBB,PPP2CA,CBL,FGF17,MAPK1,UBC,PTPN11,FGF9
R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	0.220479538341381	-1.51195038503884	99	90	0.00996236440115121	9034	10285	148022,5594,1848,9641,64127,29110,466,7867,10454,5518,7189,7323,5609,9261,6288,8454,4790,1385,7334,7321,6195,5599,1386,5604,6500,841,23118,6283,6196,4205,5598,7316,4615,8737,9252,353376,4792,5601,1849,10392,330,3665,23291,5970,8945,5608,1147,5519,51231,5781,1846,929,7314,5515,79155,8767,6416,5602,4791,5516,7098,3551,2353,4793,1326,1432,10010,3656,8772,11035,7322,351,1660,5600,7311,4208,5595,5528,3661,7187,329,23643,3146,6233,6885,177,7099,7335,5606,3725	TICAM1,MAPK1,DUSP6,IKBKE,NOD2,TBK1,ATF1,MAPKAPK3,TAB1,PPP2R1A,TRAF6,UBE2D3,MAP2K7,MAPKAPK2,SAA1,CUL1,NFKB1,CREB1,UBE2N,UBE2D1,RPS6KA1,MAPK8,ATF2,MAP2K1,SKP1,CASP8,TAB2,S100A12,RPS6KA2,MEF2A,MAPK7,UBC,MYD88,RIPK1,RPS6KA5,TICAM2,NFKBIA,MAPK9,DUSP7,NOD1,BIRC3,IRF7,FBXW11,RELA,BTRC,MAP2K6,CHUK,PPP2R1B,VRK3,PTPN11,DUSP4,CD14,UBB,PPP2CA,TNIP2,RIPK2,MAP2K4,MAPK10,NFKB2,PPP2CB,TLR3,IKBKB,FOS,NFKBIB,MAP3K8,MAPK14,TANK,IRAK2,FADD,RIPK3,UBE2D2,APP,DHX9,MAPK11,UBA52,MEF2C,MAPK3,PPP2R5D,IRF3,TRAF3,BIRC2,LY96,HMGB1,RPS27A,MAP3K7,AGER,TLR4,UBE2V1,MAP2K3,JUN
R-HSA-937061	TRIF-mediated TLR3/TLR4 signaling	0.220479538341381	-1.51195038503884	99	90	0.00996236440115121	9034	10285	3665,23291,10392,1849,330,5601,4792,1147,5519,5608,5970,8945,7316,4615,4205,5598,353376,8737,9252,6195,5599,7321,7334,4790,1385,23118,6283,6196,841,5604,6500,1386,64127,29110,466,1848,9641,148022,5594,6288,8454,5609,7323,9261,7189,7867,10454,5518,6885,23643,3146,6233,7187,329,5528,3661,3725,5606,7335,177,7099,3656,4208,5595,1660,5600,7311,11035,7322,351,8772,4793,2353,3551,10010,1432,1326,5515,79155,1846,929,7314,5781,51231,4791,7098,5516,5602,8767,6416	IRF7,FBXW11,NOD1,DUSP7,BIRC3,MAPK9,NFKBIA,CHUK,PPP2R1B,MAP2K6,RELA,BTRC,UBC,MYD88,MEF2A,MAPK7,TICAM2,RIPK1,RPS6KA5,RPS6KA1,MAPK8,UBE2D1,UBE2N,NFKB1,CREB1,TAB2,S100A12,RPS6KA2,CASP8,MAP2K1,SKP1,ATF2,NOD2,TBK1,ATF1,DUSP6,IKBKE,TICAM1,MAPK1,SAA1,CUL1,MAP2K7,UBE2D3,MAPKAPK2,TRAF6,MAPKAPK3,TAB1,PPP2R1A,MAP3K7,LY96,HMGB1,RPS27A,TRAF3,BIRC2,PPP2R5D,IRF3,JUN,MAP2K3,UBE2V1,AGER,TLR4,IRAK2,MEF2C,MAPK3,DHX9,MAPK11,UBA52,RIPK3,UBE2D2,APP,FADD,NFKBIB,FOS,IKBKB,TANK,MAPK14,MAP3K8,PPP2CA,TNIP2,DUSP4,CD14,UBB,PTPN11,VRK3,NFKB2,TLR3,PPP2CB,MAPK10,RIPK2,MAP2K4
R-HSA-166166	MyD88-independent TLR3/TLR4 cascade	0.220479538341381	-1.51195038503884	99	90	0.00996236440115121	9034	10285	79155,5515,7314,929,1846,5781,51231,5516,7098,4791,5602,8767,6416,4793,2353,3551,10010,1432,1326,3656,5595,4208,7311,5600,1660,351,7322,11035,8772,6885,6233,23643,3146,329,7187,3661,5528,3725,5606,7335,7099,177,466,29110,64127,9641,1848,5594,148022,8454,6288,9261,5609,7323,7189,5518,10454,7867,5599,6195,7321,7334,1385,4790,6196,6283,23118,841,6500,5604,1386,4615,7316,5598,4205,353376,9252,8737,23291,3665,330,10392,1849,5601,4792,5519,1147,5608,8945,5970	TNIP2,PPP2CA,UBB,CD14,DUSP4,PTPN11,VRK3,PPP2CB,TLR3,NFKB2,MAPK10,RIPK2,MAP2K4,NFKBIB,FOS,IKBKB,TANK,MAPK14,MAP3K8,IRAK2,MAPK3,MEF2C,UBA52,MAPK11,DHX9,APP,UBE2D2,RIPK3,FADD,MAP3K7,RPS27A,LY96,HMGB1,BIRC2,TRAF3,IRF3,PPP2R5D,JUN,MAP2K3,UBE2V1,TLR4,AGER,ATF1,TBK1,NOD2,IKBKE,DUSP6,MAPK1,TICAM1,CUL1,SAA1,MAPKAPK2,MAP2K7,UBE2D3,TRAF6,PPP2R1A,TAB1,MAPKAPK3,MAPK8,RPS6KA1,UBE2D1,UBE2N,CREB1,NFKB1,RPS6KA2,S100A12,TAB2,CASP8,SKP1,MAP2K1,ATF2,MYD88,UBC,MAPK7,MEF2A,TICAM2,RPS6KA5,RIPK1,FBXW11,IRF7,BIRC3,NOD1,DUSP7,MAPK9,NFKBIA,PPP2R1B,CHUK,MAP2K6,BTRC,RELA
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	0.220479538341381	-1.51195038503884	99	90	0.00996236440115121	9034	10285	6857,920,85021,58513,84251,7316,25977,6456,11037,9856,6455,6457,22848,85439,1212,10987,1173,3949,8674,23208,10254,6869,2873,1950,163,917,157,8533,23149,8673,4074,1080,27348,55707,950,4036,1956,29979,9318,50618,160,156,8301,29988,7018,10618,50813,127833,408,1175,9341,8027,7311,6453,3482,6233,7474,143425,409,8218,3267,29924,7037,867,185,338,7314,9146,10920,22905,915,1861,115548,1211,2060,1129,64708,1601,26119,2885,8322,51138,6844,161,90019,1213,551,9892,154,1856	SYT1,CD4,REPS1,EPS15L1,SGIP1,UBC,NECAP1,SH3GL2,STON1,KIAA0319,SH3GL1,SH3GL3,AAK1,STON2,CLTB,COPS5,AP2M1,LDLR,VAMP4,SYT11,STAM2,TACR1,GPS1,EGF,AP2B1,CD3G,GRK3,COPS3,FCHO1,VAMP8,M6PR,CFTR,TOR1B,NECAP2,SCARB2,LRP2,EGFR,UBQLN1,COPS2,ITSN2,AP2A1,GRK2,PICALM,SLC2A8,TF,TGOLN2,COPS7A,SYT2,ARRB1,AP2S1,VAMP3,STAM,UBA52,ITSN1,IGF2R,RPS27A,WNT5A,SYT9,ARRB2,CLTCL1,AGFG1,EPN1,TFRC,CBL,AGTR1,APOB,UBB,HGS,COPS8,EPN2,CD3D,TOR1A,FCHO2,CLTA,EPS15,CHRM2,COPS7B,DAB2,LDLRAP1,GRB2,FZD4,COPS4,VAMP2,AP2A2,SYT8,CLTC,AVP,SNAP91,ADRB2,DVL2
R-HSA-5663220	RHO GTPases Activate Formins	0.222757423208532	-1.50167188789566	117	106	0.0117334514058003	9034	10285	3796,5347,81565,80152,4928,1062,55839,55920,81624,998,22919,64946,54820,5526,55746,25936,57122,701,5527,5525,5519,699,55055,79682,23380,332,23002,1060,57551,10403,80776,57082,1058,5518,10726,29984,11243,5879,991,6232,5903,84643,23279,57405,81929,9735,79980,11130,23122,64105,71,9184,83540,5048,6249,151246,5217,79902,4085,5528,3688,6722,3619,79019,6396,51466,5216,60,348995,23421,81930,57591,114793,54908,389,25909,387,1729,1063,100616122,5515,5529,9793,8379,79172,9212,5905,286205,5516,11004,79023,5501,401541,91010,147841,388,752,1857,7514,1855,6714,9183,23332,220134,1856,151648	KIF2A,PLK1,NDEL1,CENPT,NUP98,CENPE,CENPN,RCC2,DIAPH3,CDC42,MAPRE1,CENPH,NDE1,PPP2R5B,NUP133,NSL1,NUP107,BUB1B,PPP2R5C,PPP2R5A,PPP2R1B,BUB1,ZWILCH,CENPU,SRGAP2,BIRC5,DAAM1,CENPC,TAOK1,NDC80,B9D2,KNL1,CENPA,PPP2R1A,NUDC,RHOD,PMF1,RAC1,CDC20,RPS27,RANBP2,KIF2B,NUP160,SPC25,SEH1L,KNTC1,DSN1,ZWINT,CLASP2,CENPK,ACTG1,BUB3,NUF2,PAFAH1B1,CLIP1,SGO2,PFN2,NUP85,MAD2L1,PPP2R5D,ITGB1,SRF,INCENP,CENPM,SEC13,EVL,PFN1,ACTB,NUP43,ITGB3BP,KIF18A,MRTFA,FMNL2,SPDL1,RHOC,AHCTF1,RHOA,DIAPH1,CENPF,MIR4523,PPP2CA,PPP2R5E,CKAP5,MAD1L1,CENPO,AURKB,RANGAP1,SCAI,PPP2CB,KIF2C,NUP37,PPP1CC,CENPP,FMNL3,SPC24,RHOB,FMNL1,DVL3,XPO1,DVL1,SRC,ZW10,CLASP1,SKA1,DVL2,SGO1
R-HSA-168898	Toll-Like Receptors Cascades	0.222801824621017	-1.50147258146067	153	138	0.0152756254150985	9034	10285	9252,8737,353376,6279,671,5598,4205,7316,4615,1515,11213,59307,30849,1147,5519,8945,5970,5608,1508,5289,1849,10392,330,23291,3665,9450,3929,4792,5601,5609,7323,5641,9261,8454,6288,5336,10454,7867,7096,5518,7189,29110,64127,466,51295,4214,5594,148022,7097,1848,57162,9641,841,23118,6196,6283,1386,7100,64145,6500,5604,7334,7321,6195,5775,5599,4064,1385,4790,5600,1660,10333,7311,2243,948,5595,4208,81793,8772,11035,7322,351,3656,54106,1513,57161,5606,100500842,3725,1785,2266,177,7099,7335,23643,3146,6233,6885,5528,3661,26052,329,7187,5602,4791,8411,5516,7098,6416,81622,8767,246330,929,1846,7314,5515,338,79155,3689,51231,5781,1520,1432,2244,114609,10010,51135,6280,1326,8651,2353,1759,4793,10695,3684,170506,3551,1514	RPS6KA5,RIPK1,TICAM2,S100A8,BPI,MAPK7,MEF2A,UBC,MYD88,CTSV,IRAK3,SIGIRR,PIK3R4,CHUK,PPP2R1B,BTRC,RELA,MAP2K6,CTSB,PIK3C3,DUSP7,NOD1,BIRC3,FBXW11,IRF7,LY86,LBP,NFKBIA,MAPK9,MAP2K7,UBE2D3,LGMN,MAPKAPK2,CUL1,SAA1,PLCG2,TAB1,MAPKAPK3,TLR1,PPP2R1A,TRAF6,TBK1,NOD2,ATF1,ECSIT,MAP3K1,MAPK1,TICAM1,TLR2,DUSP6,PELI1,IKBKE,CASP8,TAB2,RPS6KA2,S100A12,ATF2,TLR5,RBSN,SKP1,MAP2K1,UBE2N,UBE2D1,RPS6KA1,PTPN4,MAPK8,CD180,CREB1,NFKB1,MAPK11,DHX9,TLR6,UBA52,FGA,CD36,MAPK3,MEF2C,TLR10,FADD,RIPK3,UBE2D2,APP,IRAK2,TLR9,CTSK,PELI2,MAP2K3,MIR3652,JUN,DNM2,FGG,AGER,TLR4,UBE2V1,LY96,HMGB1,RPS27A,MAP3K7,PPP2R5D,IRF3,DNM3,BIRC2,TRAF3,MAPK10,NFKB2,EEA1,PPP2CB,TLR3,MAP2K4,UNC93B1,RIPK2,PELI3,CD14,DUSP4,UBB,PPP2CA,APOB,TNIP2,ITGB2,VRK3,PTPN11,CTSS,MAPK14,FGB,TIRAP,TANK,IRAK4,S100A9,MAP3K8,SOCS1,FOS,DNM1,NFKBIB,CNPY3,ITGAM,DHX36,IKBKB,CTSL
R-HSA-168253	Host Interactions with Influenza Factors	0.231308763793704	-1.46400182116852	42	39	0.00431702457383219	9034	10285	4927,79023,3837,8021,9636,9883,9631,81929,5610,8086,11097,9688,3838,7040,55706,4928,7175,3836,9818,129401,10762,100101267,23636,23165,5903,348995,23511,23279,402569,53371,8106,79902,3840,23225,9972,55746,10898,3839,57122	NUP88,NUP37,KPNB1,NUP214,ISG15,POM121,NUP155,SEH1L,EIF2AK2,AAAS,NUP42,NUP93,KPNA2,TGFB1,NDC1,NUP98,TPR,KPNA1,NUP58,NUP35,NUP50,POM121C,NUP62,NUP205,RANBP2,NUP43,NUP188,NUP160,KPNA7,NUP54,PABPN1,NUP85,KPNA4,NUP210,NUP153,NUP133,CPSF4,KPNA3,NUP107
R-HSA-1566948	Elastic fibre formation	0.231308763793704	-1.46400182116852	42	39	0.00431702457383219	9034	10285	8076,3690,2200,2202,655,84695,10516,650,4238,8425,27302,4236,2192,3688,2199,3693,4052,84171,3685,4237,4053,5045,3696,4016,652,7040,7042,30008,2006,4239,8200,7043,3694,4015,4017,8516,84467,2201,4054	MFAP5,ITGB3,FBN1,EFEMP1,BMP7,LOXL3,FBLN5,BMP2,MFAP3,LTBP4,BMP10,MFAP1,FBLN1,ITGB1,FBLN2,ITGB5,LTBP1,LOXL4,ITGAV,MFAP2,LTBP2,FURIN,ITGB8,LOXL1,BMP4,TGFB1,TGFB2,EFEMP2,ELN,MFAP4,GDF5,TGFB3,ITGB6,LOX,LOXL2,ITGA8,FBN3,FBN2,LTBP3
R-HSA-3928662	EPHB-mediated forward signaling	0.231308763793704	-1.46400182116852	42	39	0.00431702457383219	9034	10285	60,1072,2048,6383,4067,64283,3265,2904,1949,6714,10093,10109,5879,2050,5921,2047,6453,5058,10552,1948,3985,2534,9475,5747,10096,998,2051,10094,7074,71,8976,2049,10095,10092,10097,8997,7525,387,3984	ACTB,CFL1,EPHB2,SDC2,LYN,ARHGEF28,HRAS,GRIN2B,EFNB3,SRC,ARPC4,ARPC2,RAC1,EPHB4,RASA1,EPHB1,ITSN1,PAK1,ARPC1A,EFNB2,LIMK2,FYN,ROCK2,PTK2,ACTR3,CDC42,EPHB6,ARPC3,TIAM1,ACTG1,WASL,EPHB3,ARPC1B,ARPC5,ACTR2,KALRN,YES1,RHOA,LIMK1
R-HSA-983189	Kinesins	0.231308763793704	-1.46400182116852	42	39	0.00431702457383219	9034	10285	84643,29127,10112,81930,64837,55605,56992,9493,3799,3833,146909,147700,55582,23046,9585,547,64147,3832,3797,11004,3831,11127,10749,89953,22920,55083,124602,3835,221458,3796,3834,23095,113220,55614,26153,1062,23303,3798,285643	KIF2B,RACGAP1,KIF20A,KIF18A,KLC2,KIF21A,KIF15,KIF23,KIF5B,KIFC1,KIF18B,KLC3,KIF27,KIF21B,KIF20B,KIF1A,KIF9,KIF11,KIF3C,KIF2C,KLC1,KIF3A,KIF1C,KLC4,KIFAP3,KIF26B,KIF19,KIF22,KIF6,KIF2A,KIF25,KIF1B,KIF12,KIF16B,KIF26A,CENPE,KIF13B,KIF5A,KIF4B
R-HSA-5693607	Processing of DNA double-strand break ends	0.231332500875801	-1.46389920566951	98	89	0.00985167146336064	9034	10285	144715,51720,54962,5810,8924,672,5984,9156,9656,84142,151987,5531,641,8364,11073,7468,472,4683,6119,7314,8363,8340,8970,7336,6118,6233,3017,8368,8346,83695,116028,6613,7158,7311,5983,8361,80010,9577,8347,8345,7341,8349,128312,8900,8362,580,890,7334,5884,5982,1111,51548,8344,29086,63967,8290,84126,7486,8359,10111,165918,4361,8339,6117,83990,8343,8360,545,5985,3364,7329,1017,6047,7156,1763,51588,8348,10524,121504,8366,7316,8914,8370,8341,8365,3018,5883,8367,9025	RAD9B,UIMC1,TIPIN,RAD1,HERC2,BRCA1,RFC4,EXO1,MDC1,ABRAXAS1,PPP4R2,PPP4C,BLM,H4C3,TOPBP1,NSD2,ATM,NBN,RPA3,UBB,H4C11,H2BC13,H2BC11,UBE2V2,RPA2,RPS27A,H2BC5,H4C13,H2BC10,RHNO1,RMI2,SUMO2,TP53BP1,UBA52,RFC3,H4C6,RMI1,BABAM2,H2BC4,H2BC9,SUMO1,H2BC21,H2BC26,CCNA1,H4C12,BARD1,CCNA2,UBE2N,RAD17,RFC2,CHEK1,SIRT6,H2BC6,BABAM1,CLSPN,H3-4,ATRIP,WRN,H4C1,RAD50,RNF168,MRE11,H2BC8,RPA1,BRIP1,H2BC7,H4C4,ATR,RFC5,HUS1,UBE2I,CDK2,RNF4,TOP3A,DNA2,PIAS4,H2BC17,KAT5,H4C16,H4C2,UBC,TIMELESS,H4C14,H2BC15,H4C8,H2BC3,RAD9A,H4C5,RNF8
R-HSA-453279	Mitotic G1-G1/S phases	0.232302843070303	-1.45971340049331	143	129	0.0142793889749834	9034	10285	1032,4171,993,7314,4999,5719,23595,5515,6119,6241,5693,5702,5516,208,7027,1019,1027,5714,5691,1871,4331,3065,1026,8318,990,5698,4173,891,207,10213,5001,5720,898,5558,5713,1030,55388,5684,1022,896,4605,7298,4174,5699,7311,91750,5700,5718,4998,1869,5925,6118,595,5111,6233,5707,5711,132660,5694,1874,7084,5706,7153,10000,9134,5000,4175,7465,5685,81620,5687,5933,5753,5518,10926,1870,983,5690,8454,5686,55957,84515,1875,4609,890,5695,1021,8317,5704,6500,5696,8900,1028,286826,26271,7979,7316,4149,23594,5710,5520,54107,7029,1017,1029,1859,894,5692,10197,5557,9491,902,5701,5427,5934,5708,9861,6502,56655,4172,1719,1031,5717,23649,5928,5682,5519,5715,6117	CDKN2D,MCM2,CDC25A,UBB,ORC2,PSMD13,ORC3,PPP2CA,RPA3,RRM2,PSMB5,PSMC3,PPP2CB,AKT2,TFDP1,CDK4,CDKN1B,PSMD8,PSMB3,E2F3,MNAT1,HDAC1,CDKN1A,CDC45,CDC6,PSMB9,MCM4,CCNB1,AKT1,PSMD14,ORC5,PSME1,CCNE1,PRIM2,PSMD7,CDKN2B,MCM10,PSMA3,CDK7,CCND3,MYBL2,TYMS,MCM5,PSMB10,UBA52,LIN52,PSMC1,PSMD12,ORC1,E2F1,RB1,RPA2,CCND1,PCNA,RPS27A,PSMD1,PSMD5,LIN54,PSMB6,E2F4,TK2,PSMC6,TOP2A,AKT3,CCNE2,ORC4,MCM6,WEE1,PSMA4,CDT1,PSMA6,RBL1,PTK6,PPP2R1A,DBF4,E2F2,CDK1,PSMB2,CUL1,PSMA5,LIN37,MCM8,E2F5,MYC,CCNA2,PSMB7,CDK6,CDC7,PSMC4,SKP1,PSMB8,CCNA1,CDKN1C,LIN9,FBXO5,SEM1,UBC,MAX,ORC6,PSMD4,PPP2R2A,POLE3,TFDP2,CDK2,CDKN2A,DYRK1A,CCND2,PSMB4,PSME3,PRIM1,PSMF1,CCNH,PSMC2,POLE2,RBL2,PSMD2,PSMD6,SKP2,POLE4,MCM3,DHFR,CDKN2C,PSMD11,POLA2,RBBP4,PSMA1,PPP2R1B,PSMD9,RPA1
R-HSA-69273	Cyclin A/B1 associated events during G2/M transition	0.232999171456152	-1.45672038140494	22	21	0.00232455169360195	9034	10285	995,983,891,1022,5518,4331,9088,1017,8900,5519,5516,993,7514,890,9133,902,7465,5520,5515,5347,994	CDC25C,CDK1,CCNB1,CDK7,PPP2R1A,MNAT1,PKMYT1,CDK2,CCNA1,PPP2R1B,PPP2CB,CDC25A,XPO1,CCNA2,CCNB2,CCNH,WEE1,PPP2R2A,PPP2CA,PLK1,CDC25B
R-HSA-5621575	CD209 (DC-SIGN) signaling	0.232999171456152	-1.45672038140494	22	21	0.00232455169360195	9034	10285	5062,4893,5970,9252,30835,2534,5568,3265,3384,5566,2033,100302237,4067,3845,1387,4790,3385,5058,5567,5894,5971	PAK2,NRAS,RELA,RPS6KA5,CD209,FYN,PRKACG,HRAS,ICAM2,PRKACA,EP300,MIR1281,LYN,KRAS,CREBBP,NFKB1,ICAM3,PAK1,PRKACB,RAF1,RELB
R-HSA-166208	mTORC1-mediated signalling	0.232999171456152	-1.45672038140494	22	21	0.00232455169360195	9034	10285	29904,7529,6009,1981,64121,6194,6198,64223,58528,1975,57521,28956,10542,1977,389541,8649,1978,2475,55004,84335,10670	EEF2K,YWHAB,RHEB,EIF4G1,RRAGC,RPS6,RPS6KB1,MLST8,RRAGD,EIF4B,RPTOR,LAMTOR2,LAMTOR5,EIF4E,LAMTOR4,LAMTOR3,EIF4EBP1,MTOR,LAMTOR1,AKT1S1,RRAGA
R-HSA-2142691	Synthesis of Leukotrienes (LT) and Eoxins (EX)	0.232999171456152	-1.45672038140494	22	21	0.00232455169360195	9034	10285	2678,241,1800,246,9261,1579,57834,4056,1580,284541,240,8529,4363,91227,22949,2687,64174,64180,11283,4048,126410	GGT1,ALOX5AP,DPEP1,ALOX15,MAPKAPK2,CYP4A11,CYP4F11,LTC4S,CYP4B1,CYP4A22,ALOX5,CYP4F2,ABCC1,GGTLC2,PTGR1,GGT5,DPEP2,DPEP3,CYP4F8,LTA4H,CYP4F22
R-HSA-4641263	Regulation of FZD by ubiquitination	0.232999171456152	-1.45672038140494	22	21	0.00232455169360195	9034	10285	8323,284654,89780,7316,4040,7855,9101,340419,7314,6233,8322,343637,84870,54894,59352,4041,7311,84133,8549,55366,8325	FZD6,RSPO1,WNT3A,UBC,LRP6,FZD5,USP8,RSPO2,UBB,RPS27A,FZD4,RSPO4,RSPO3,RNF43,LGR6,LRP5,UBA52,ZNRF3,LGR5,LGR4,FZD8
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer	0.232999171456152	-1.45672038140494	22	21	0.00232455169360195	9034	10285	2261,5335,2247,2254,2253,8074,2250,8822,6654,8817,5290,4893,2885,2549,2246,2249,26281,3265,10818,5295,3845	FGFR3,PLCG1,FGF2,FGF9,FGF8,FGF23,FGF5,FGF17,SOS1,FGF18,PIK3CA,NRAS,GRB2,GAB1,FGF1,FGF4,FGF20,HRAS,FRS2,PIK3R1,KRAS
R-HSA-5655332	Signaling by FGFR3 in disease	0.232999171456152	-1.45672038140494	22	21	0.00232455169360195	9034	10285	5290,8817,8822,6654,2250,2254,2253,8074,2247,5335,2261,3845,10818,5295,3265,26281,2246,2549,2249,4893,2885	PIK3CA,FGF18,FGF17,SOS1,FGF5,FGF9,FGF8,FGF23,FGF2,PLCG1,FGFR3,KRAS,FRS2,PIK3R1,HRAS,FGF20,FGF1,GAB1,FGF4,NRAS,GRB2
R-HSA-168274	Export of Viral Ribonucleoproteins from Nucleus	0.235089538256944	-1.44778882354599	32	30	0.00332078813371707	9034	10285	81929,9631,55706,5901,9688,8086,11097,129401,9818,7175,4928,4927,79023,9883,8021,53371,9972,23225,79902,55746,57122,7514,10762,5903,100101267,23636,23165,23511,348995,23279	SEH1L,NUP155,NDC1,RAN,NUP93,AAAS,NUP42,NUP35,NUP58,TPR,NUP98,NUP88,NUP37,POM121,NUP214,NUP54,NUP153,NUP210,NUP85,NUP133,NUP107,XPO1,NUP50,RANBP2,POM121C,NUP62,NUP205,NUP188,NUP43,NUP160
R-HSA-399721	Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	0.235089538256944	-1.44778882354599	32	30	0.00332078813371707	9034	10285	9463,1739,815,9495,817,27092,1742,10368,2893,5582,100126325,1175,5578,163,2890,4646,2891,23426,1173,4905,2036,160,818,4193,80852,59283,5579,10369,161,816	PICK1,DLG1,CAMK2A,AKAP5,CAMK2D,CACNG4,DLG4,CACNG3,GRIA4,PRKCG,MIR935,AP2S1,PRKCA,AP2B1,GRIA1,MYO6,GRIA2,GRIP1,AP2M1,NSF,EPB41L1,AP2A1,CAMK2G,MDM2,GRIP2,CACNG8,PRKCB,CACNG2,AP2A2,CAMK2B
R-HSA-1592389	Activation of Matrix Metalloproteinases	0.235089538256944	-1.44778882354599	32	30	0.00332078813371707	9034	10285	4318,7177,4314,7077,10893,1513,5045,5644,4316,50859,4323,1215,64386,4317,4320,4322,440387,4313,4312,4325,4319,3818,4324,3817,1511,1504,1991,1515,5340,4326	MMP9,TPSAB1,MMP3,TIMP2,MMP24,CTSK,FURIN,PRSS1,MMP7,SPOCK3,MMP14,CMA1,MMP25,MMP8,MMP11,MMP13,CTRB2,MMP2,MMP1,MMP16,MMP10,KLKB1,MMP15,KLK2,CTSG,CTRB1,ELANE,CTSV,PLG,MMP17
R-HSA-451326	Activation of Kainate Receptors upon glutamate binding	0.235089538256944	-1.44778882354599	32	30	0.00332078813371707	9034	10285	1739,2782,805,2783,83988,2900,1742,51764,5331,10681,801,59345,2899,2791,2790,2792,2786,2788,5330,2784,2897,808,2793,54331,2898,2901,23236,2787,55970,94235	DLG1,GNB1,CALM2,GNB2,NCALD,GRIK4,DLG4,GNG13,PLCB3,GNB5,CALM1,GNB4,GRIK3,GNG11,GNG10,GNGT1,GNG4,GNG7,PLCB2,GNB3,GRIK1,CALM3,GNGT2,GNG2,GRIK2,GRIK5,PLCB1,GNG5,GNG12,GNG8
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	0.235089538256944	-1.44778882354599	32	30	0.00332078813371707	9034	10285	2776,2782,2151,10672,5595,2149,2783,51764,2769,10681,5594,59345,2791,408,6714,2790,2792,2786,2767,2788,2784,2793,9630,54331,55970,2787,2147,409,2768,94235	GNAQ,GNB1,F2RL2,GNA13,MAPK3,F2R,GNB2,GNG13,GNA15,GNB5,MAPK1,GNB4,GNG11,ARRB1,SRC,GNG10,GNGT1,GNG4,GNA11,GNG7,GNB3,GNGT2,GNA14,GNG2,GNG12,GNG5,F2,ARRB2,GNA12,GNG8
R-HSA-376176	Signaling by Robo receptor	0.235089538256944	-1.44778882354599	32	30	0.00332078813371707	9034	10285	23380,57144,8440,10486,23122,6092,10487,9353,998,9901,27,5058,6654,64221,5217,5879,6091,4690,10298,25,2817,7408,51466,5216,23332,6655,5062,55740,57522,56924	SRGAP2,PAK5,NCK2,CAP2,CLASP2,ROBO2,CAP1,SLIT2,CDC42,SRGAP3,ABL2,PAK1,SOS1,ROBO3,PFN2,RAC1,ROBO1,NCK1,PAK4,ABL1,GPC1,VASP,EVL,PFN1,CLASP1,SOS2,PAK2,ENAH,SRGAP1,PAK6
R-HSA-399719	Trafficking of AMPA receptors	0.235089538256944	-1.44778882354599	32	30	0.00332078813371707	9034	10285	1739,9463,10368,1742,27092,817,9495,815,100126325,5582,2893,2890,163,5578,1175,4905,1173,23426,2891,4646,80852,4193,818,160,2036,5579,59283,816,161,10369	DLG1,PICK1,CACNG3,DLG4,CACNG4,CAMK2D,AKAP5,CAMK2A,MIR935,PRKCG,GRIA4,GRIA1,AP2B1,PRKCA,AP2S1,NSF,AP2M1,GRIP1,GRIA2,MYO6,GRIP2,MDM2,CAMK2G,AP2A1,EPB41L1,PRKCB,CACNG8,CAMK2B,AP2A2,CACNG2
R-HSA-2485179	Activation of the phototransduction cascade	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	6295,9187,6010,5145,5158,5148,1258,2782,2779,1259,2792	SAG,SLC24A1,RHO,PDE6A,PDE6B,PDE6G,CNGB1,GNB1,GNAT1,CNGA1,GNGT1
R-HSA-1839122	Signaling by activated point mutants of FGFR1	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	2246,2249,2251,2260,26281,2247,8074,2253,2254,8822,2250	FGF1,FGF4,FGF6,FGFR1,FGF20,FGF2,FGF23,FGF8,FGF9,FGF17,FGF5
R-HSA-75072	mRNA Editing	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	164668,10930,27350,339,100913187,29974,9582,104,200315,403314,103	APOBEC3H,APOBEC2,APOBEC3C,APOBEC1,APOBEC3A_B,A1CF,APOBEC3B,ADARB1,APOBEC3A,APOBEC4,ADAR
R-HSA-71182	Phenylalanine and tyrosine catabolism	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	3242,883,5092,5053,2184,259307,3081,5860,6898,80150,2954	HPD,KYAT1,PCBD1,PAH,FAH,IL4I1,HGD,QDPR,TAT,ASRGL1,GSTZ1
R-HSA-193048	Androgen biosynthesis	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	1586,3283,3284,6716,51144,79644,3293,5443,1081,6715,3972	CYP17A1,HSD3B1,HSD3B2,SRD5A2,HSD17B12,SRD5A3,HSD17B3,POMC,CGA,SRD5A1,LHB
R-HSA-629594	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	1134,55584,1142,1138,1141,1143,1135,1139,1136,1137,8973	CHRNA1,CHRNA9,CHRNB3,CHRNA5,CHRNB2,CHRNB4,CHRNA2,CHRNA7,CHRNA3,CHRNA4,CHRNA6
R-HSA-446107	Type I hemidesmosome assembly	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	977,1308,3655,667,100422894,3918,3914,3909,5339,100126326,3691	CD151,COL17A1,ITGA6,DST,MIR4260,LAMC2,LAMB3,LAMA3,PLEC,MIR936,ITGB4
R-HSA-351906	Apoptotic cleavage of cell adhesion  proteins	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	1828,9414,1829,999,7082,1499,100506658,836,5317,1830,1832	DSG1,TJP2,DSG2,CDH1,TJP1,CTNNB1,OCLN,CASP3,PKP1,DSG3,DSP
R-HSA-1059683	Interleukin-6 signaling	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	9021,6772,5781,6774,3569,7297,3717,867,3570,3572,3716	SOCS3,STAT1,PTPN11,STAT3,IL6,TYK2,JAK2,CBL,IL6R,IL6ST,JAK1
R-HSA-549127	Organic cation transport	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	85413,6580,6582,861,6584,6583,100506403,5002,6248,55356,6581	SLC22A16,SLC22A1,SLC22A2,RUNX1,SLC22A5,SLC22A4,LOC100506403,SLC22A18,RSC1A1,SLC22A15,SLC22A3
R-HSA-5655291	Signaling by FGFR4 in disease	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	2549,2264,4893,2885,5295,10818,3845,3265,5335,6654,5290	GAB1,FGFR4,NRAS,GRB2,PIK3R1,FRS2,KRAS,HRAS,PLCG1,SOS1,PIK3CA
R-HSA-5625970	RHO GTPases activate KTN1	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	3799,3831,89953,391,387,147700,3895,64837,3798,998,5879	KIF5B,KLC1,KLC4,RHOG,RHOA,KLC3,KTN1,KLC2,KIF5A,CDC42,RAC1
R-HSA-376172	DSCAM interactions	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	57453,5879,5599,9423,5058,1826,5603,1630,5600,6300,1432	DSCAML1,RAC1,MAPK8,NTN1,PAK1,DSCAM,MAPK13,DCC,MAPK11,MAPK12,MAPK14
R-HSA-8851805	MET activates RAS signaling	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	3265,200958,10048,6654,4233,3845,6464,2885,3082,4893,57610	HRAS,MUC20,RANBP9,SOS1,MET,KRAS,SHC1,GRB2,HGF,NRAS,RANBP10
R-HSA-68689	CDC6 association with the ORC:origin complex	0.239945083164898	-1.42734520196973	11	11	0.00121762231569626	9034	10285	5000,84515,4998,1869,4999,23595,1871,23594,990,1870,5001	ORC4,MCM8,ORC1,E2F1,ORC2,ORC3,E2F3,ORC6,CDC6,E2F2,ORC5
R-HSA-397795	G-protein beta:gamma signalling	0.240331593609573	-1.42573566918662	51	47	0.00520256807615674	9034	10285	3718,2885,3716,208,2782,3567,59345,5170,3568,10000,5293,10681,3717,5290,5331,51764,387,3558,5291,2784,5330,5295,6464,23533,2792,207,1439,94235,8503,5296,55970,3560,54331,2783,3559,146850,2791,1437,2793,2788,2786,2790,5294,9846,2787,23236,3562	JAK3,GRB2,JAK1,AKT2,GNB1,IL5,GNB4,PDPK1,IL5RA,AKT3,PIK3CD,GNB5,JAK2,PIK3CA,PLCB3,GNG13,RHOA,IL2,PIK3CB,GNB3,PLCB2,PIK3R1,SHC1,PIK3R5,GNGT1,AKT1,CSF2RB,GNG8,PIK3R3,PIK3R2,GNG12,IL2RB,GNG2,GNB2,IL2RA,PIK3R6,GNG11,CSF2,GNGT2,GNG7,GNG4,GNG10,PIK3CG,GAB2,GNG5,PLCB1,IL3
R-HSA-1989781	PPARA activates gene expression	0.242963496610458	-1.41484406663575	124	112	0.0123976090325437	9034	10285	9442,4800,100302237,4899,7004,2101,55090,90390,6721,6822,51129,1376,27063,9915,5469,1490,2222,2274,6667,54600,10498,6256,6604,335,51,1543,211,1387,4802,9440,27242,84246,7296,219541,10001,23097,51003,10499,79718,400569,51586,892,2180,3992,11010,116519,1024,7003,10891,29841,4520,8841,9967,5468,405,81857,336,85441,9969,57761,123,96764,8648,1581,80205,8202,50486,9572,8800,4862,19,196,10413,6720,26230,34,4801,948,2033,5244,10025,80306,1374,133522,1579,112950,3156,406,9439,9971,9443,9477,57491,8463,3157,23179,54797,7005,9575,183,25937,23389,23054,4199,5465,2168,9412,6095,376497,9611,29079,9441	MED27,NFYA,MIR1281,NRF1,TEAD4,ESRRA,MED9,MED30,SREBF2,SULT2A1,ANGPTL4,CPT2,ANKRD1,ARNT2,MED1,CCN2,FDFT1,FHL2,SP1,UGT1A9,CARM1,RXRA,SMARCD3,APOA1,ACOX1,CYP1A1,ALAS1,CREBBP,NFYC,MED17,TNFRSF21,MED10,TXNRD1,MED19,MED6,CDK19,MED31,NCOA2,TBL1XR1,MED11,MED15,CCNC,ACSL1,FADS1,GLIPR1,APOA5,CDK8,TEAD1,PPARGC1A,GRHL1,MTF1,HDAC3,THRAP3,PPARG,ARNT,MED25,APOA2,HELZ2,MED13,TRIB3,PLIN2,TGS1,NCOA1,CYP7A1,CHD9,NCOA3,G0S2,NR1D1,PEX11A,NPAS2,ABCA1,AHR,YAP1,SREBF1,TIAM2,ACADM,NFYB,CD36,EP300,ABCB4,MED16,MED28,CPT1A,PPARGC1B,CYP4A11,MED8,HMGCR,BMAL1,MED23,NR1H4,MED7,MED20,AHRR,TEAD2,HMGCS1,RGL1,MED18,TEAD3,CLOCK,AGT,WWTR1,MED13L,NCOA6,ME1,PPARA,FABP1,MED21,RORA,SLC27A1,NCOR1,MED4,MED26
R-HSA-166054	Activated TLR4 signalling	0.243215389478308	-1.41380785178728	115	104	0.0115120655302192	9034	10285	7099,177,7335,5606,3725,3661,5528,7187,329,6233,3146,23643,6885,8772,7322,351,11035,7311,10333,1660,5600,4208,5595,948,57161,3656,51135,1326,1432,10010,114609,3551,2353,8651,4793,246330,6416,8767,5602,7098,5516,4791,51231,5781,7314,1846,929,79155,5515,5970,8945,5608,11213,5519,1147,59307,4792,5601,330,1849,10392,3665,23291,8737,9252,353376,4205,5598,4615,7316,1386,5604,6500,841,6283,6196,23118,4790,1385,7334,7321,5599,6195,7096,5518,7867,10454,7189,9261,7323,5609,6288,8454,7097,148022,5594,57162,9641,1848,466,64127,29110,4214,51295	TLR4,AGER,UBE2V1,MAP2K3,JUN,IRF3,PPP2R5D,TRAF3,BIRC2,RPS27A,HMGB1,LY96,MAP3K7,FADD,UBE2D2,APP,RIPK3,UBA52,TLR6,DHX9,MAPK11,MEF2C,MAPK3,CD36,PELI2,IRAK2,IRAK4,MAP3K8,MAPK14,TANK,TIRAP,IKBKB,FOS,SOCS1,NFKBIB,PELI3,MAP2K4,RIPK2,MAPK10,TLR3,PPP2CB,NFKB2,VRK3,PTPN11,UBB,DUSP4,CD14,TNIP2,PPP2CA,RELA,BTRC,MAP2K6,IRAK3,PPP2R1B,CHUK,SIGIRR,NFKBIA,MAPK9,BIRC3,DUSP7,NOD1,IRF7,FBXW11,RIPK1,RPS6KA5,TICAM2,MEF2A,MAPK7,MYD88,UBC,ATF2,MAP2K1,SKP1,CASP8,S100A12,RPS6KA2,TAB2,NFKB1,CREB1,UBE2N,UBE2D1,MAPK8,RPS6KA1,TLR1,PPP2R1A,MAPKAPK3,TAB1,TRAF6,MAPKAPK2,UBE2D3,MAP2K7,SAA1,CUL1,TLR2,TICAM1,MAPK1,PELI1,IKBKE,DUSP6,ATF1,NOD2,TBK1,MAP3K1,ECSIT
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	0.246129017416732	-1.40189941948777	60	55	0.00608811157848129	9034	10285	1277,1297,1295,1301,4314,100313843,50509,1296,3655,1280,1306,1298,1278,3691,1285,84695,1281,1290,5118,1515,3918,649,1286,7092,5339,1300,1508,1293,4016,256076,4316,9313,3909,4318,100500837,977,4017,255631,4015,667,4322,1282,1289,1294,1514,84171,1299,85301,1520,100422894,131873,3914,7093,1284,1302	COL1A1,COL9A1,COL8A1,COL11A1,MMP3,MIR711,COL5A3,COL8A2,ITGA6,COL2A1,COL15A1,COL9A2,COL1A2,ITGB4,COL4A3,LOXL3,COL3A1,COL5A2,PCOLCE,CTSV,LAMC2,BMP1,COL4A4,TLL1,PLEC,COL10A1,CTSB,COL6A3,LOXL1,COL6A5,MMP7,MMP20,LAMA3,MMP9,MIR3606,CD151,LOXL2,COL24A1,LOX,DST,MMP13,COL4A1,COL5A1,COL7A1,CTSL,LOXL4,COL9A3,COL27A1,CTSS,MIR4260,COL6A6,LAMB3,TLL2,COL4A2,COL11A2
R-HSA-5654743	Signaling by FGFR4	0.248218139492631	-1.39344732470555	41	38	0.00420633163604162	9034	10285	26281,7311,10818,5595,5516,3845,4893,2885,5518,2249,10817,2251,7314,5515,867,8822,8817,5290,5594,5335,7316,5781,2254,3265,6714,5295,6464,2264,10253,2246,2549,6233,9965,6654,673,2247,8074,2253	FGF20,UBA52,FRS2,MAPK3,PPP2CB,KRAS,NRAS,GRB2,PPP2R1A,FGF4,FRS3,FGF6,UBB,PPP2CA,CBL,FGF17,FGF18,PIK3CA,MAPK1,PLCG1,UBC,PTPN11,FGF9,HRAS,SRC,PIK3R1,SHC1,FGFR4,SPRY2,FGF1,GAB1,RPS27A,FGF19,SOS1,BRAF,FGF2,FGF23,FGF8
R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	0.248218139492631	-1.39344732470555	41	38	0.00420633163604162	9034	10285	10714,6118,51455,5985,83932,6233,5981,7415,5111,5427,5424,56655,11201,5984,100500827,7353,6117,10459,124739,7316,7706,7314,7318,6119,9246,54107,57804,5980,9636,5982,51426,5983,7311,25898,9100,55666,100847079,5429	POLD3,RPA2,REV1,RFC5,SPRTN,RPS27A,RFC1,VCP,PCNA,POLE2,POLD1,POLE4,POLI,RFC4,MIR3614,UFD1,RPA1,MAD2L2,USP43,UBC,TRIM25,UBB,UBA7,RPA3,UBE2L6,POLE3,POLD4,REV3L,ISG15,RFC2,POLK,RFC3,UBA52,RCHY1,USP10,NPLOC4,MIR5193,POLH
R-HSA-73894	DNA Repair	0.249184214379779	-1.38956283926071	316	282	0.0312154084569404	9034	10285	8368,3017,4968,8346,7158,146956,6613,404672,1643,7374,5983,10721,9100,100847079,80010,8345,7318,3150,5887,5395,27343,8970,5441,283899,7874,7336,10635,6118,5434,197342,22909,54890,6233,5981,7320,57804,10973,64708,8505,5429,51426,55215,472,7398,55183,5433,10920,6119,4798,2968,54617,57654,55775,144715,2956,8924,5431,64421,79728,672,79840,10459,9156,5984,22976,91603,86,54778,25,151987,84142,5892,5531,125476,11200,2070,79913,3978,51138,641,252969,7329,1763,6047,348654,2175,1017,11284,51588,84464,7157,2176,124739,8914,5432,8341,221120,9025,8367,3018,4361,8343,4350,6117,8360,7515,29089,1161,5985,8607,199990,5427,5893,7516,7415,5888,5982,2967,1642,4436,6612,8344,1111,23583,29086,25898,5889,84126,4255,9246,55120,8930,6917,10038,7706,23514,7341,5536,79661,7353,8178,3980,91442,5599,7334,57461,9636,1022,83695,5423,2140,116028,2033,353497,7311,8361,51750,9577,9978,8347,2178,5439,3838,50813,8363,80233,60,8340,8314,4292,11201,27434,5886,7518,5890,51455,4595,121642,2072,2188,7507,5111,51514,11073,9031,8364,7468,4913,675,3981,55666,64858,2189,4683,7314,54962,51720,51008,5810,142,5424,4331,54891,7520,100500827,2067,9656,27033,9937,84164,83932,5980,2177,7156,54107,5591,2139,10524,8348,8366,121504,51567,7316,322,9557,5440,8370,2074,8451,10450,6996,5883,8365,56655,85015,8467,10111,165918,7508,9716,83990,8339,7517,93973,56852,545,9682,10987,902,201254,3364,7528,57697,2965,79068,2071,8533,51548,100302237,23030,63967,2547,8290,8554,5430,8359,7486,2873,10445,8349,8900,2138,128312,580,8362,2068,890,10714,9318,2073,5884,2237	H4C13,H2BC5,OGG1,H2BC10,TP53BP1,EME1,SUMO2,GTF2H5,DDB2,UNG,RFC3,POLQ,USP10,MIR5193,RMI1,H2BC9,UBA7,HMGN1,RAD23B,PMS2,POLL,H2BC11,POLR2L,INO80E,USP7,UBE2V2,RAD51AP1,RPA2,POLR2E,EME2,FAN1,ALKBH5,RPS27A,RFC1,UBE2B,POLD4,ASCC3,COPS7B,PARG,POLH,POLK,FANCI,ATM,USP1,RIF1,POLR2D,COPS8,RPA3,NFRKB,GTF2H4,INO80,UVSSA,TDP1,RAD9B,MSH6,HERC2,POLR2B,DCLRE1C,PALB2,BRCA1,NHEJ1,MAD2L2,EXO1,RFC4,PAXIP1,ZNF830,ACTL6A,RNF111,ABL1,PPP4R2,ABRAXAS1,RAD51D,PPP4C,INO80C,CHEK2,EYA4,ACTR5,LIG1,COPS4,BLM,NEIL2,UBE2I,DNA2,RNF4,GEN1,FANCA,CDK2,PNKP,PIAS4,SLX4,TP53,FANCC,USP43,TIMELESS,POLR2C,H2BC15,ALKBH3,RNF8,H4C5,H2BC3,MRE11,H2BC7,MPG,RPA1,H4C4,XRCC1,UBE2T,ERCC8,RFC5,RUVBL1,FAAP20,POLE2,RAD52,XRCC2,VCP,RAD51,RFC2,GTF2H3,DDB1,MSH2,SUMO3,H2BC6,CHEK1,SMUG1,BABAM1,RCHY1,RAD51C,ATRIP,MGMT,UBE2L6,FANCL,MBD4,TCEA1,PARP2,TRIM25,SPIDR,SUMO1,PPP5C,NEIL1,UFD1,ELL,LIG3,FAAP24,MAPK8,UBE2N,ISY1,ISG15,CDK7,RHNO1,POLB,EYA3,RMI2,EP300,POLN,UBA52,H4C6,RTEL1,BABAM2,RBX1,H2BC4,FANCE,POLR2J,KPNA2,COPS7A,H4C11,FAAP100,ACTB,H2BC13,BAP1,MLH1,POLI,POLM,RAD23A,XRCC4,RAD51B,REV1,MUTYH,ALKBH2,ERCC4,FANCF,XPA,PCNA,DTL,TOPBP1,BAZ1B,H4C3,NSD2,NTHL1,BRCA2,LIG4,NPLOC4,DCLRE1B,FANCG,NBN,UBB,TIPIN,UIMC1,ASCC1,RAD1,PARP1,POLD1,MNAT1,INO80D,XRCC5,MIR3614,ERCC1,MDC1,ZBTB32,DCLRE1A,ASCC2,SPRTN,REV3L,FANCD2,TOP3A,POLE3,PRKDC,EYA2,KAT5,H2BC17,H4C2,H4C16,TDP2,UBC,APBB1,CHD1L,POLR2K,H4C14,ERCC6,CUL4A,PPIE,TDG,RAD9A,H4C8,POLE4,USP45,SMARCA5,RAD50,RNF168,XPC,AQR,BRIP1,H2BC8,XRCC3,ACTR8,RAD18,ATR,KDM4A,COPS5,CCNH,CENPX,HUS1,YY1,FANCM,GTF2H1,FTO,ERCC3,COPS3,SIRT6,MIR1281,KDM4B,CLSPN,XRCC6,H3-4,PIAS1,POLR2A,H4C1,WRN,GPS1,MCRS1,H2BC21,CCNA1,EYA1,H2BC26,BARD1,H4C12,ERCC2,CCNA2,POLD3,COPS2,ERCC5,RAD17,FEN1
R-HSA-388841	Costimulation by the CD28 family	0.249859205347047	-1.38685769837634	69	63	0.00697365508080584	9034	10285	80380,3119,3127,29126,151888,9402,5528,5526,5058,5519,5525,4067,5527,253260,9020,117145,920,3120,79109,998,3123,942,5879,23308,5296,8503,5777,2475,941,29851,3113,1326,916,5062,3932,5295,6714,940,207,1493,5170,5781,1445,915,10000,917,919,5290,5529,5515,55615,7409,3118,7525,57761,3117,2534,3122,5518,64223,2885,208,5516	PDCD1LG2,HLA-DQB1,HLA-DRB5,CD274,BTLA,GRAP2,PPP2R5D,PPP2R5B,PAK1,PPP2R1B,PPP2R5A,LYN,PPP2R5C,RICTOR,MAP3K14,THEM4,CD4,HLA-DQB2,MAPKAP1,CDC42,HLA-DRB1,CD86,RAC1,ICOSLG,PIK3R2,PIK3R3,PTPN6,MTOR,CD80,ICOS,HLA-DPA1,MAP3K8,CD3E,PAK2,LCK,PIK3R1,SRC,CD28,AKT1,CTLA4,PDPK1,PTPN11,CSK,CD3D,AKT3,CD3G,CD247,PIK3CA,PPP2R5E,PPP2CA,PRR5,VAV1,HLA-DQA2,YES1,TRIB3,HLA-DQA1,FYN,HLA-DRA,PPP2R1A,MLST8,GRB2,AKT2,PPP2CB
R-HSA-2129379	Molecules associated with elastic fibres	0.254569806191852	-1.36818019301075	31	29	0.0032100951959265	9034	10285	3685,4052,4053,4237,10516,650,4238,655,2202,3690,8076,3693,2192,4236,2199,3688,8425,27302,4054,8516,7040,652,7042,3696,3694,4239,8200,7043,30008	ITGAV,LTBP1,LTBP2,MFAP2,FBLN5,BMP2,MFAP3,BMP7,EFEMP1,ITGB3,MFAP5,ITGB5,FBLN1,MFAP1,FBLN2,ITGB1,LTBP4,BMP10,LTBP3,ITGA8,TGFB1,BMP4,TGFB2,ITGB8,ITGB6,MFAP4,GDF5,TGFB3,EFEMP2
R-HSA-73893	DNA Damage Bypass	0.256080719582157	-1.3622625733348	50	46	0.00509187513836617	9034	10285	54107,5980,9636,5983,7311,9100,100847079,124739,9978,7316,7318,8451,56655,11201,6117,51455,6118,56852,5985,6233,5981,7415,5111,5427,1642,7320,57804,51514,5982,51426,25898,55666,7398,5429,7706,7314,6119,9246,5424,5984,100500827,7353,10459,27033,10714,83932	POLE3,REV3L,ISG15,RFC3,UBA52,USP10,MIR5193,USP43,RBX1,UBC,UBA7,CUL4A,POLE4,POLI,RPA1,REV1,RPA2,RAD18,RFC5,RPS27A,RFC1,VCP,PCNA,POLE2,DDB1,UBE2B,POLD4,DTL,RFC2,POLK,RCHY1,NPLOC4,USP1,POLH,TRIM25,UBB,RPA3,UBE2L6,POLD1,RFC4,MIR3614,UFD1,MAD2L2,ZBTB32,POLD3,SPRTN
R-HSA-3000480	Scavenging by Class A Receptors	0.256232654868454	-1.3616694391387	21	20	0.00221385875581138	9034	10285	8685,1281,811,100500837,335,5648,2495,1277,81035,338,117156,1284,348,286133,1278,78989,2512,100500842,4481,1282	MARCO,COL3A1,CALR,MIR3606,APOA1,MASP1,FTH1,COL1A1,COLEC12,APOB,SCGB3A2,COL4A2,APOE,SCARA5,COL1A2,COLEC11,FTL,MIR3652,MSR1,COL4A1
R-HSA-500657	Presynaptic function of Kainate receptors	0.256232654868454	-1.3616694391387	21	20	0.00221385875581138	9034	10285	10681,59345,2899,94235,2791,54331,51764,23236,2787,55970,5331,2788,2784,5330,2783,2793,2790,2792,2782,2786	GNB5,GNB4,GRIK3,GNG8,GNG11,GNG2,GNG13,PLCB1,GNG5,GNG12,PLCB3,GNG7,GNB3,PLCB2,GNB2,GNGT2,GNG10,GNGT1,GNB1,GNG4
R-HSA-6807004	Negative regulation of MET activity	0.256232654868454	-1.3616694391387	21	20	0.00221385875581138	9034	10285	3082,2885,6457,26018,6455,2060,8027,7311,5770,5771,6456,9101,9146,7316,6233,7314,5795,867,4233,10254	HGF,GRB2,SH3GL3,LRIG1,SH3GL1,EPS15,STAM,UBA52,PTPN1,PTPN2,SH3GL2,USP8,HGS,UBC,RPS27A,UBB,PTPRJ,CBL,MET,STAM2
R-HSA-5423646	Aflatoxin activation and detoxification	0.256232654868454	-1.3616694391387	21	20	0.00221385875581138	9034	10285	22977,91227,4257,246181,124975,91703,1577,1544,2687,64174,64180,1553,1800,4259,2678,4258,95,2679,2686,1576	AKR7A3,GGTLC2,MGST1,AKR7L,GGT6,ACY3,CYP3A5,CYP1A2,GGT5,DPEP2,DPEP3,CYP2A13,DPEP1,MGST3,GGT1,MGST2,ACY1,GGT3P,GGT7,CYP3A4
R-HSA-2142753	Arachidonic acid metabolism	0.26088864857789	-1.34366159649472	59	54	0.00597741864069072	9034	10285	1582,873,5445,3248,127281,2687,27306,64180,11283,4048,5446,5742,5321,1579,1559,4056,1800,145482,241,2678,113612,1544,4363,2879,8644,240,239,1580,2877,1558,246,5444,2053,5743,1543,64174,1557,126410,2876,5740,242,9536,80142,6916,9261,57834,1545,1573,91227,22949,10728,284541,8529,247	CYP8B1,CBR1,PON2,HPGD,PRXL2B,GGT5,HPGDS,DPEP3,CYP4F8,LTA4H,PON3,PTGS1,PLA2G4A,CYP4A11,CYP2C9,LTC4S,DPEP1,PTGR2,ALOX5AP,GGT1,CYP2U1,CYP1A2,ABCC1,GPX4,AKR1C3,ALOX5,ALOX12,CYP4B1,GPX2,CYP2C8,ALOX15,PON1,EPHX2,PTGS2,CYP1A1,DPEP2,CYP2C19,CYP4F22,GPX1,PTGIS,ALOX12B,PTGES,PTGES2,TBXAS1,MAPKAPK2,CYP4F11,CYP1B1,CYP2J2,GGTLC2,PTGR1,PTGES3,CYP4A22,CYP4F2,ALOX15B
R-HSA-211897	Cytochrome P450 - arranged by substrate type	0.263770429809785	-1.33267613819721	68	62	0.00686296214301528	9034	10285	405,1549,285440,11283,1562,5447,1594,1582,1589,9420,1544,120227,10499,113612,5443,1584,9971,29785,10858,1579,1592,1572,1559,2232,5740,1591,100861540,1543,66002,196,1555,1577,126410,1557,1595,1583,1558,6256,1576,56603,1580,1581,284541,8529,8648,1548,9915,1585,112812,1588,1545,1553,1593,1573,54905,6916,2230,57834,64816,51302,1565,1586	ARNT,CYP2A7,CYP4V2,CYP4F8,CYP2C18,POR,CYP27B1,CYP8B1,CYP21A2,CYP7B1,CYP1A2,CYP2R1,NCOA2,CYP2U1,POMC,CYP11B1,NR1H4,CYP2S1,CYP46A1,CYP4A11,CYP26A1,CYP2F1,CYP2C9,FDXR,PTGIS,CYP24A1,CYP3A7-CYP3A51P,CYP1A1,CYP4F12,AHR,CYP2B6,CYP3A5,CYP4F22,CYP2C19,CYP51A1,CYP11A1,CYP2C8,RXRA,CYP3A4,CYP26B1,CYP4B1,CYP7A1,CYP4A22,CYP4F2,NCOA1,CYP2A6,ARNT2,CYP11B2,FDX2,CYP19A1,CYP1B1,CYP2A13,CYP27A1,CYP2J2,CYP2W1,TBXAS1,FDX1,CYP4F11,CYP3A43,CYP39A1,CYP2D6,CYP17A1
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	0.263770429809785	-1.33267613819721	68	62	0.00686296214301528	9034	10285	197358,11128,84265,171568,7098,4791,100302237,6288,11277,3428,148022,51082,2547,340061,7314,29110,9533,115004,51728,81030,23220,7520,6283,3551,4790,1387,170506,55718,6778,10622,4793,8737,5591,10623,351,11035,7311,1660,2033,5440,6737,4615,7316,661,1499,5970,177,4361,22954,55703,5441,9208,147945,1147,4792,3661,5434,27297,6233,3146,81844,3665	NLRC3,POLR3A,POLR3GL,POLR3H,TLR3,NFKB2,MIR1281,SAA1,TREX1,IFI16,TICAM1,POLR1D,XRCC6,STING1,UBB,TBK1,POLR1C,CGAS,POLR3K,ZBP1,DTX4,XRCC5,S100A12,IKBKB,NFKB1,CREBBP,DHX36,POLR3E,STAT6,POLR3G,NFKBIB,RIPK1,PRKDC,POLR3C,APP,RIPK3,UBA52,DHX9,EP300,POLR2K,TRIM21,MYD88,UBC,POLR3D,CTNNB1,RELA,AGER,MRE11,TRIM32,POLR3B,POLR2L,LRRFIP1,NLRP4,CHUK,NFKBIA,IRF3,POLR2E,CRCP,RPS27A,HMGB1,TRIM56,IRF7
R-HSA-69620	Cell Cycle Checkpoints	0.265424822934218	-1.3264236311856	201	180	0.0199247288023024	9034	10285	7529,11065,7324,5715,83990,5682,8339,165918,10111,3364,5701,545,7533,121504,8366,10524,9491,10197,8348,7156,7531,5883,23594,8365,8370,7316,8362,580,8900,128312,5704,8349,5884,7321,890,5690,5686,10926,7486,5685,8359,8290,63967,25946,5000,7534,5706,5711,8340,995,8363,4085,7311,5699,116028,83695,5684,2810,4194,5713,9577,8347,8361,10213,1026,5810,891,51720,4193,5698,7532,5714,9656,51434,5702,7468,11073,10393,8364,7314,4683,8379,23595,119504,993,701,8360,4172,6117,8343,5717,5708,4361,9861,5985,9133,5692,51588,122706,1763,9088,1017,51512,8367,9025,3018,8341,143471,5710,23198,7157,996,7979,5696,7341,64326,5695,7334,8317,84515,991,29086,8344,1111,64682,983,5982,4175,5687,57060,7465,84126,9134,8970,5694,6233,25906,5707,6118,4998,5718,7336,5983,7158,5700,8346,9184,8368,4174,3017,8345,898,80010,55388,51529,5984,5001,9156,5720,672,8318,8924,4173,144715,990,10971,641,51433,1027,11200,5691,84142,8697,472,29945,5693,6119,4999,5719,4171	YWHAB,UBE2C,UBE2E1,PSMD9,BRIP1,PSMA1,H2BC8,RNF168,RAD50,HUS1,PSMC2,ATR,YWHAH,H4C16,H4C2,KAT5,PSMF1,PSME3,H2BC17,TOP3A,YWHAE,RAD9A,ORC6,H4C8,H4C14,UBC,H4C12,BARD1,CCNA1,H2BC26,PSMC4,H2BC21,RAD17,UBE2D1,CCNA2,PSMB2,PSMA5,DBF4,WRN,PSMA4,H4C1,H3-4,CLSPN,ZNF385A,ORC4,YWHAZ,PSMC6,PSMD5,H2BC13,CDC25C,H4C11,MAD2L1,UBA52,PSMB10,RMI2,RHNO1,PSMA3,SFN,MDM4,PSMD7,BABAM2,H2BC4,H4C6,PSMD14,CDKN1A,RAD1,CCNB1,UIMC1,MDM2,PSMB9,YWHAG,PSMD8,MDC1,ANAPC7,PSMC3,NSD2,TOPBP1,ANAPC10,H4C3,UBB,NBN,MAD1L1,ORC3,ANAPC16,CDC25A,BUB1B,H4C4,MCM3,RPA1,H2BC7,PSMD11,PSMD2,MRE11,PSMD6,RFC5,CCNB2,PSMB4,PIAS4,PSMB11,DNA2,PKMYT1,CDK2,GTSE1,H4C5,RNF8,H2BC3,H2BC15,PSMA8,PSMD4,PSME4,TP53,CDC27,SEM1,PSMB8,SUMO1,COP1,PSMB7,UBE2N,CDC7,MCM8,CDC20,BABAM1,H2BC6,CHEK1,ANAPC1,CDK1,RFC2,MCM6,PSMA6,PCBP4,WEE1,ATRIP,CCNE2,H2BC11,PSMB6,RPS27A,ANAPC15,PSMD1,RPA2,ORC1,PSMD12,UBE2V2,RFC3,TP53BP1,PSMC1,H2BC10,BUB3,H4C13,MCM5,H2BC5,H2BC9,CCNE1,RMI1,MCM10,ANAPC11,RFC4,ORC5,EXO1,PSME1,BRCA1,CDC45,HERC2,MCM4,RAD9B,CDC6,YWHAQ,BLM,ANAPC5,CDKN1B,CHEK2,PSMB3,ABRAXAS1,CDC23,ATM,ANAPC4,PSMB5,RPA3,ORC2,PSMD13,MCM2
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	0.266062424986687	-1.3240243173325	40	37	0.00409563869825105	9034	10285	7341,3815,1026,348,163732,10765,2064,94115,1956,4609,2099,1387,29028,8089,5308,7021,7422,1081,4869,284252,4605,79047,7329,7528,1082,7020,3329,7022,2033,100302237,339488,93659,7913,7039,51741,10370,83741	SUMO1,KIT,CDKN1A,APOE,CITED4,KDM5B,ERBB2,CGB8,EGFR,MYC,ESR1,CREBBP,ATAD2,YEATS4,PITX2,TFAP2B,VEGFA,CGA,NPM1,KCTD1,MYBL2,KCTD15,UBE2I,YY1,CGB3,TFAP2A,HSPD1,TFAP2C,EP300,MIR1281,TFAP2E,CGB5,DEK,TGFA,WWOX,CITED2,TFAP2D
R-HSA-5675221	Negative regulation of MAPK pathway	0.266062424986687	-1.3240243173325	40	37	0.00409563869825105	9034	10285	1843,5528,5526,8315,673,1849,6233,5605,5604,5536,5527,5525,5519,3265,11221,7529,1848,7316,4140,1844,5037,5594,152559,80824,5894,5529,5515,1846,7314,1850,5518,4893,5595,5516,3845,1847,7311	DUSP1,PPP2R5D,PPP2R5B,BRAP,BRAF,DUSP7,RPS27A,MAP2K2,MAP2K1,PPP5C,PPP2R5C,PPP2R5A,PPP2R1B,HRAS,DUSP10,YWHAB,DUSP6,UBC,MARK3,DUSP2,PEBP1,MAPK1,PAQR3,DUSP16,RAF1,PPP2R5E,PPP2CA,DUSP4,UBB,DUSP8,PPP2R1A,NRAS,MAPK3,PPP2CB,KRAS,DUSP5,UBA52
R-HSA-69473	G2/M DNA damage checkpoint	0.266115343797105	-1.32382544089046	95	86	0.00951959264998893	9034	10285	7158,116028,5983,8368,2810,3017,83695,8346,80010,8361,8345,8347,9577,8970,995,8363,8340,7336,6118,472,11073,8364,7468,4683,6119,672,5984,9156,891,51720,144715,5810,8924,641,10971,7532,9656,84142,11200,10524,51588,8348,121504,8366,7531,7156,1763,8370,8341,9025,5883,8367,8365,3018,7157,6117,8343,83990,8339,7529,8360,4361,10111,165918,3364,5985,545,7533,8344,1111,29086,983,5982,7465,7486,8359,7534,84126,8290,128312,8362,580,7341,8349,5884,7334	TP53BP1,RMI2,RFC3,H4C13,SFN,H2BC5,RHNO1,H2BC10,RMI1,H4C6,H2BC9,H2BC4,BABAM2,H2BC11,CDC25C,H4C11,H2BC13,UBE2V2,RPA2,ATM,TOPBP1,H4C3,NSD2,NBN,RPA3,BRCA1,RFC4,EXO1,CCNB1,UIMC1,RAD9B,RAD1,HERC2,BLM,YWHAQ,YWHAG,MDC1,ABRAXAS1,CHEK2,KAT5,PIAS4,H2BC17,H4C16,H4C2,YWHAE,TOP3A,DNA2,H4C14,H2BC15,RNF8,RAD9A,H4C5,H4C8,H2BC3,TP53,RPA1,H2BC7,BRIP1,H2BC8,YWHAB,H4C4,MRE11,RAD50,RNF168,HUS1,RFC5,ATR,YWHAH,H2BC6,CHEK1,BABAM1,CDK1,RFC2,WEE1,WRN,H4C1,YWHAZ,ATRIP,H3-4,H2BC26,H4C12,BARD1,SUMO1,H2BC21,RAD17,UBE2N
R-HSA-196854	Metabolism of vitamins and cofactors	0.272470466106965	-1.30022505201135	174	156	0.0172680982953288	9034	10285	6383,8566,3141,5091,1727,1719,11330,3949,1582,9446,10560,5826,55739,1645,5948,55065,10588,151056,81034,60490,56965,51109,8034,200895,31,316,7276,8875,23475,4363,9672,349565,952,441024,5644,8876,4522,56922,55788,10082,27249,1504,4035,7804,83666,4337,4594,79646,2638,27304,2350,344,8029,335,6513,4036,5743,4552,683,345,1208,1528,5641,9962,326625,4837,5406,9227,5167,57016,338328,160728,166785,29914,55163,10840,84875,10797,55034,55229,26020,5169,1109,51293,5950,5095,27010,1594,54981,27231,375790,5947,143,54625,60386,25902,2817,6470,80704,6947,65220,5096,81693,10243,79001,32,54,9963,4023,686,55191,160428,119391,9390,4548,60496,79717,8644,29967,120227,55312,6385,80308,113278,348,6382,4907,4338,5740,83594,80025,154807,440387,8884,6472,1591,337,23057,64802,53354,54956,128240,2694,79178,6515,336,2262,5168,55937,4524,3339,10135,5646,53630,338,2194	SDC2,PDXK,HLCS,PC,CYB5R3,DHFR,CTRC,LDLR,CYP8B1,GSTO1,SLC19A2,ABCD4,NAXD,AKR1C1,RBP2,SLC52A1,MTHFS,PLB1,SLC25A32,PPCDC,PARP6,RDH11,SLC25A16,DHFR2,ACACA,AOX1,TTR,VNN2,QPRT,ABCC1,SDC3,NMNAT3,CD38,MTHFD2L,PRSS1,VNN1,MTHFD1,MCCC1,LMBRD1,GPC6,MMADHC,CTRB1,LRP1,LRP8,PARP9,MOCS1,MMUT,PANK3,GC,MOCS3,FOLR2,APOC2,CUBN,APOA1,SLC2A1,LRP2,PTGS2,MTRR,BST1,APOC3,CLPS,CYB5A,LGMN,SLC23A2,MMAB,NNMT,PNLIP,LRAT,ENPP1,AKR1B10,GPIHBP1,SLC5A8,MMAA,UBIAD1,PNPO,ALDH1L1,PARP10,MTHFD2,MOCOS,PANK4,LRP10,ENPP3,AKR1C4,CD320,RBP4,PCCA,TPK1,CYP27B1,NMRK1,NMRK2,AGRN,RBP1,PARP4,PARP14,SLC25A19,MTHFD1L,GPC1,SHMT1,SLC19A3,TCN1,NADK,PCCB,AMN,GPHN,VKORC1,ACACB,ACP5,SLC23A1,LPL,BTD,NADSYN1,ALDH1L2,GSTO2,SLC22A13,MTR,AASDHPPT,PPCS,AKR1C3,LRP12,CYP2R1,RFK,SDC4,FLAD1,SLC52A3,APOE,SDC1,NT5E,MOCS2,PTGIS,NUDT12,PANK2,VKORC1L1,CTRB2,SLC5A6,SHMT2,CYP24A1,APOA4,NMNAT2,NMNAT1,PANK1,PARP16,NAXE,CBLIF,THTPA,SLC2A3,APOA2,GPC5,ENPP2,APOM,MTHFR,HSPG2,NAMPT,PRSS3,BCO1,APOB,FASN
R-HSA-418886	Netrin mediated repulsion signals	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	219699,5747,5781,90249,2534,8633,137970,6714,1630,9423	UNC5B,PTK2,PTPN11,UNC5A,FYN,UNC5C,UNC5D,SRC,DCC,NTN1
R-HSA-8853334	Signaling by FGFR3 fusions in cancer	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	2261,4893,2885,2549,3265,6654,5295,10818,5290,3845	FGFR3,NRAS,GRB2,GAB1,HRAS,SOS1,PIK3R1,FRS2,PIK3CA,KRAS
R-HSA-428643	Organic anion transporters	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	57084,79751,246213,6568,6528,26503,83733,160728,1468,57030	SLC17A6,SLC25A22,SLC17A8,SLC17A1,SLC5A5,SLC17A5,SLC25A18,SLC5A8,SLC25A10,SLC17A7
R-HSA-74749	Signal attenuation	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	2885,2887,8660,5594,6464,3667,6654,5595,3630,3643	GRB2,GRB10,IRS2,MAPK1,SHC1,IRS1,SOS1,MAPK3,INS,INSR
R-HSA-190873	Gap junction degradation	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	1601,1211,1213,1212,1759,4646,8218,1173,1785,2697	DAB2,CLTA,CLTC,CLTB,DNM1,MYO6,CLTCL1,AP2M1,DNM2,GJA1
R-HSA-113507	E2F-enabled inhibition of pre-replication complex formation	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	84515,5000,891,983,993,4998,4999,23595,23594,5001	MCM8,ORC4,CCNB1,CDK1,CDC25A,ORC1,ORC2,ORC3,ORC6,ORC5
R-HSA-73929	Base-Excision Repair, AP Site Formation	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	23583,8930,4350,252969,79661,6996,7374,4968,4913,4595	SMUG1,MBD4,MPG,NEIL2,NEIL1,TDG,UNG,OGG1,NTHL1,MUTYH
R-HSA-399997	Acetylcholine regulates insulin secretion	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	9630,5330,5578,4082,2769,2767,5331,1131,2776,23236	GNA14,PLCB2,PRKCA,MARCKS,GNA15,GNA11,PLCB3,CHRM3,GNAQ,PLCB1
R-HSA-8866904	Negative regulation of activity of TFAP2 (AP-2) family transcription factors	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	51741,7020,7022,7329,79047,284252,7341,83741,339488,7021	WWOX,TFAP2A,TFAP2C,UBE2I,KCTD15,KCTD1,SUMO1,TFAP2D,TFAP2E,TFAP2B
R-HSA-74259	Purine catabolism	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	84618,93034,22978,4907,4860,847,30833,7498,2876,9615	NT5C1A,NT5C1B,NT5C2,NT5E,PNP,CAT,NT5C,XDH,GPX1,GDA
R-HSA-1250342	PI3K events in ERBB4 signaling	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	685,2069,1839,2066,145957,10718,5290,9542,3084,5295	BTC,EREG,HBEGF,ERBB4,NRG4,NRG3,PIK3CA,NRG2,NRG1,PIK3R1
R-HSA-190377	FGFR2b ligand binding and activation	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	2248,2252,9982,143282,27006,2255,2247,2246,2263,83888	FGF3,FGF7,FGFBP1,FGFBP3,FGF22,FGF10,FGF2,FGF1,FGFR2,FGFBP2
R-HSA-2161522	Abacavir transport and metabolism	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	9429,2987,6582,161823,6580,5105,6581,5243,22978,124	ABCG2,GUK1,SLC22A2,ADAL,SLC22A1,PCK1,SLC22A3,ABCB1,NT5C2,ADH1A
R-HSA-450341	Activation of the AP-1 family of transcription factors	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	5601,5594,1386,5599,3725,5595,2353,1432,5600,5602	MAPK9,MAPK1,ATF2,MAPK8,JUN,MAPK3,FOS,MAPK14,MAPK11,MAPK10
R-HSA-425381	Bicarbonate transporters	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	6522,83697,9497,23382,57835,9498,57282,6521,6508,8671	SLC4A2,SLC4A9,SLC4A7,AHCYL2,SLC4A5,SLC4A8,SLC4A10,SLC4A1,SLC4A3,SLC4A4
R-HSA-3215018	Processing and activation of SUMO	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	7329,7341,6612,205564,10054,6613,10055,59343,29843,25950	UBE2I,SUMO1,SUMO3,SENP5,UBA2,SUMO2,SAE1,SENP2,SENP1,RWDD3
R-HSA-170660	Adenylate cyclase activating pathway	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	108,107,112,109,113,115,111,114,2774,196883	ADCY2,ADCY1,ADCY6,ADCY3,ADCY7,ADCY9,ADCY5,ADCY8,GNAL,ADCY4
R-HSA-196108	Pregnenolone biosynthesis	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	231,134429,10948,2230,2232,147323,6770,1583,112812,83930	AKR1B1,STARD4,STARD3,FDX1,FDXR,STARD6,STAR,CYP11A1,FDX2,STARD3NL
R-HSA-2562578	TRIF-mediated programmed cell death	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	23643,841,929,7098,148022,8772,8737,7099,11035,353376	LY96,CASP8,CD14,TLR3,TICAM1,FADD,RIPK1,TLR4,RIPK3,TICAM2
R-HSA-2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	5600,5565,1432,6300,10891,5571,51422,53632,5564,5563	MAPK11,PRKAB2,MAPK14,MAPK12,PPARGC1A,PRKAG1,PRKAG2,PRKAG3,PRKAB1,PRKAA2
R-HSA-975578	Reactions specific to the complex N-glycan synthesis pathway	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	1081,2530,2517,64377,4122,2525,4247,3972,9486,4124	CGA,FUT8,FUCA1,CHST8,MAN2A2,FUT3,MGAT2,LHB,CHST10,MAN2A1
R-HSA-110056	MAPK3 (ERK1) activation	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	983,5604,5781,3572,3570,3716,5595,3717,3569,7297	CDK1,MAP2K1,PTPN11,IL6ST,IL6R,JAK1,MAPK3,JAK2,IL6,TYK2
R-HSA-389887	Beta-oxidation of pristanoyl-CoA	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	6342,54677,23600,390916,55289,1384,8310,8309,3295,10005	SCP2,CROT,AMACR,NUDT19,ACOXL,CRAT,ACOX3,ACOX2,HSD17B4,ACOT8
R-HSA-209968	Thyroxine biosynthesis	0.273208746631993	-1.29751913630753	10	10	0.00110692937790569	9034	10285	7173,53905,389434,7252,1081,6528,1735,1734,50506,1733	TPO,DUOX1,IYD,TSHB,CGA,SLC5A5,DIO3,DIO2,DUOX2,DIO1
R-HSA-2871809	FCERI mediated Ca+2 mobilization	0.275318587841855	-1.28982635061719	30	28	0.00309940225813593	9034	10285	7409,3937,801,3708,5335,7410,5530,5532,5336,4775,2885,805,10451,7294,3709,4773,3702,6654,4772,9402,10768,27040,6850,3710,4067,6464,5534,808	VAV1,LCP2,CALM1,ITPR1,PLCG1,VAV2,PPP3CA,PPP3CB,PLCG2,NFATC3,GRB2,CALM2,VAV3,TXK,ITPR2,NFATC2,ITK,SOS1,NFATC1,GRAP2,AHCYL1,LAT,SYK,ITPR3,LYN,SHC1,PPP3R1,CALM3
R-HSA-157118	Signaling by NOTCH	0.276218953486716	-1.28656141803435	112	101	0.0111799867168475	9034	10285	388585,8841,4855,6868,79885,4192,1024,83464,5986,5045,4242,55534,79718,23493,7157,9759,892,7316,192669,23462,7029,83933,26523,6484,23112,1385,55294,1387,113878,4609,23509,6400,1272,83737,7090,27327,6500,3002,9148,3091,51564,10959,142678,8788,57690,9734,100302237,8454,22938,9612,8650,6233,595,54492,9611,3516,8850,9794,92737,1869,488,409,5870,10014,10402,3725,6487,4343,5664,9978,408,487,489,192670,7311,3280,2033,3714,4853,2683,7089,51107,1840,1871,182,54567,27161,7027,3066,7088,3955,3065,4854,23220,102,26508,84441,7314,7091,2208,23385	HES5,HDAC3,NOTCH4,ADAM17,HDAC11,MDK,CDK8,APH1B,RFNG,FURIN,MFNG,MAML3,TBL1XR1,HEY2,TP53,HDAC4,CCNC,UBC,AGO3,HEY1,TFDP2,HDAC10,AGO1,ST3GAL4,TNRC6B,CREB1,FBXW7,CREBBP,DTX2,MYC,POFUT1,SEL1L,CNTN1,ITCH,TLE3,TNRC6A,SKP1,GZMB,NEURL1,HIF1A,HDAC7,TMED2,MIB2,DLK1,TNRC6C,HDAC9,MIR1281,CUL1,SNW1,NCOR2,NUMB,RPS27A,CCND1,NEURL1B,NCOR1,RBPJ,KAT2B,MAML1,DNER,E2F1,ATP2A2,ARRB2,RAB6A,HDAC5,ST3GAL6,JUN,ST3GAL3,MOV10,PSEN2,RBX1,ARRB1,ATP2A1,ATP2A3,AGO4,UBA52,HES1,EP300,JAG2,NOTCH2,B4GALT1,TLE2,APH1A,DTX1,E2F3,JAG1,DLL4,AGO2,TFDP1,HDAC2,TLE1,LFNG,HDAC1,NOTCH3,DTX4,ADAM10,HEYL,MAML2,UBB,TLE4,FCER2,NCSTN
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	0.277119014660201	-1.28330820925743	156	140	0.0154970112906797	9034	10285	3665,9493,8358,5573,8968,653604,1793,55619,5868,3442,221037,55604,5568,25970,126961,3452,10019,221458,3796,23468,8353,7157,1062,22920,89953,3797,3660,3835,998,23028,1017,124602,23764,3659,3046,146909,3456,5879,8354,3832,161882,1387,81704,3047,23186,84643,3440,64145,2624,23414,113220,25942,3717,7465,285643,3445,1794,5889,30846,11127,100302237,55083,3020,11311,30845,147700,5567,23046,3833,2625,3661,5890,80005,9585,547,5566,55669,29127,2626,8355,9927,8357,3449,140628,832,81930,4097,10938,55614,23348,5576,23095,8350,85440,23303,3798,57572,1795,3831,5577,10749,2033,3444,5575,55582,3021,3799,3066,64147,25,3048,4602,3439,81928,3443,56992,55605,3065,9732,64837,7975,51317,10112,26153,10362,100616400,3834,4778,11216,8352,3441,8165,3043,3705,11004,3448,1020,10603,830,50808	IRF7,KIF23,H3C2,PRKAR1A,H3C7,H3C13,DOCK1,DOCK10,RAB5A,IFNA5,JMJD1C,CARMIL1,PRKACG,SH2B1,H3C14,IFNA21,SH2B3,KIF6,KIF2A,CBX5,H3C6,TP53,CENPE,KIFAP3,KLC4,KIF3C,IRF2,KIF22,CDC42,KDM1A,CDK2,KIF19,MAFF,IRF1,HBE1,KIF18B,IFNB1,RAC1,H3C11,KIF11,ZFPM1,CREBBP,DOCK8,HBG1,RCOR1,KIF2B,IFNA2,RBSN,GATA2,ZFPM2,KIF12,SIN3A,JAK2,WEE1,KIF4B,IFNA8,DOCK2,RAD51C,EHD2,KIF3A,MIR1281,KIF26B,H3-3A,VPS45,EHD3,KLC3,PRKACB,KIF21B,KIFC1,GATA3,IRF3,RAD51B,DOCK5,KIF20B,KIF1A,PRKACA,MFN1,RACGAP1,GATA4,H3C8,MFN2,H3C10,IFNA16,GATA5,CAPZB,KIF18A,MAFG,EHD1,KIF16B,DOCK9,PRKAR2A,KIF1B,H3C1,DOCK7,KIF13B,KIF5A,DOCK6,DOCK3,KLC1,PRKAR2B,KIF1C,EP300,IFNA7,PRKAR1B,KIF27,H3-3B,KIF5B,HDAC2,KIF9,ABL1,HBG2,MYB,IFNA1,CABLES2,IFNA6,KIF15,KIF21A,HDAC1,DOCK4,KLC2,MAFK,PHF21A,KIF20A,KIF26A,HMG20B,MIR3198-2,KIF25,NFE2,AKAP10,H3C3,IFNA4,AKAP1,HBB,ITPK1,KIF2C,IFNA14,CDK5,SH2B2,CAPZA2,AK3
R-HSA-1632852	Macroautophagy	0.278212646621943	-1.2793695417843	67	61	0.00675226920522471	9034	10285	9821,55062,23766,64419,51652,84971,7248,8649,5565,23710,5289,83734,11337,64422,140735,57521,56270,22863,7405,55626,30849,92421,10670,79643,25978,60673,5571,440738,28956,58528,5563,128866,64121,8897,91782,6009,26100,9776,9140,8655,2475,389541,10533,285973,55054,10542,5564,8678,84557,55004,7249,11345,84938,9474,79065,64223,53632,51422,5562,81631,8408	RB1CC1,WIPI1,GABARAPL3,MTMR14,CHMP3,ATG4D,TSC1,LAMTOR3,PRKAB2,GABARAPL1,PIK3C3,ATG10,GABARAP,ATG3,DYNLL2,RPTOR,WDR45B,ATG14,UVRAG,AMBRA1,PIK3R4,CHMP4C,RRAGA,CHMP6,CHMP2B,ATG101,PRKAG1,MAP1LC3C,LAMTOR2,RRAGD,PRKAA2,CHMP4B,RRAGC,MTMR3,CHMP7,RHEB,WIPI2,ATG13,ATG12,DYNLL1,MTOR,LAMTOR4,ATG7,ATG9B,ATG16L1,LAMTOR5,PRKAB1,BECN1,MAP1LC3A,LAMTOR1,TSC2,GABARAPL2,ATG4C,ATG5,ATG9A,MLST8,PRKAG3,PRKAG2,PRKAA1,MAP1LC3B,ULK1
R-HSA-5693606	DNA Double Strand Break Response	0.27900465054217	-1.27652682868976	76	69	0.00763781270754926	9034	10285	7157,8345,9577,8347,8361,322,7316,8367,9025,8365,3018,8370,8341,3838,8346,2139,7329,8368,3017,121504,7311,8366,10524,7158,2140,51588,8348,9682,7336,6233,8340,8314,4361,8363,165918,10111,8467,8360,8970,8343,8339,8290,7314,4683,8359,7468,9031,8364,472,29086,23030,8344,2070,11200,25,9656,84142,7334,5599,8924,8349,51720,7341,8362,580,672,128312,2138,5536	TP53,H2BC9,BABAM2,H2BC4,H4C6,APBB1,UBC,H4C5,RNF8,H4C8,H2BC3,H4C14,H2BC15,KPNA2,H2BC10,EYA2,UBE2I,H4C13,H2BC5,H4C16,UBA52,H4C2,KAT5,TP53BP1,EYA3,PIAS4,H2BC17,KDM4A,UBE2V2,RPS27A,H2BC13,BAP1,MRE11,H4C11,RNF168,RAD50,SMARCA5,H4C4,H2BC11,H2BC7,H2BC8,H3-4,UBB,NBN,H4C1,NSD2,BAZ1B,H4C3,ATM,BABAM1,KDM4B,H2BC6,EYA4,CHEK2,ABL1,MDC1,ABRAXAS1,UBE2N,MAPK8,HERC2,H2BC21,UIMC1,SUMO1,H4C12,BARD1,BRCA1,H2BC26,EYA1,PPP5C
R-HSA-6804760	Regulation of TP53 Activity through Methylation	0.281425426037664	-1.26788778288379	20	19	0.00210316581802081	9034	10285	133746,10419,4193,4194,26013,133383,387893,56950,7311,472,2033,100302237,7157,11200,91875,7316,7314,6233,10919	JMY,PRMT5,MDM2,MDM4,L3MBTL1,SETD9,KMT5A,SMYD2,UBA52,ATM,EP300,MIR1281,TP53,CHEK2,TTC5,UBC,UBB,RPS27A,EHMT2
R-HSA-418217	G beta:gamma signalling through PLC beta	0.281425426037664	-1.26788778288379	20	19	0.00210316581802081	9034	10285	2788,2783,5330,2784,2793,2792,2790,2786,2782,10681,94235,2791,59345,54331,51764,23236,5331,55970,2787	GNG7,GNB2,PLCB2,GNB3,GNGT2,GNGT1,GNG10,GNG4,GNB1,GNB5,GNG8,GNG11,GNB4,GNG2,GNG13,PLCB1,PLCB3,GNG12,GNG5
R-HSA-8876384	Listeria monocytogenes entry into host cells	0.281425426037664	-1.26788778288379	20	19	0.00210316581802081	9034	10285	7316,6456,9146,867,10254,4233,1499,7314,6233,999,2060,6455,6457,2885,79872,8027,1500,7311,6714	UBC,SH3GL2,HGS,CBL,STAM2,MET,CTNNB1,UBB,RPS27A,CDH1,EPS15,SH3GL1,SH3GL3,GRB2,CBLL1,STAM,CTNND1,UBA52,SRC
R-HSA-5654706	FRS-mediated FGFR3 signaling	0.281425426037664	-1.26788778288379	20	19	0.00210316581802081	9034	10285	3845,10818,3265,26281,2246,10817,2249,2885,4893,8817,8822,6654,2250,2254,2253,8074,5781,2247,2261	KRAS,FRS2,HRAS,FGF20,FGF1,FRS3,FGF4,GRB2,NRAS,FGF18,FGF17,SOS1,FGF5,FGF9,FGF8,FGF23,PTPN11,FGF2,FGFR3
R-HSA-190241	FGFR2 ligand binding and activation	0.281425426037664	-1.26788778288379	20	19	0.00210316581802081	9034	10285	2254,2253,8074,2247,143282,9982,2252,2250,8817,8822,83888,2263,2251,2249,2246,27006,2255,26281,2248	FGF9,FGF8,FGF23,FGF2,FGFBP3,FGFBP1,FGF7,FGF5,FGF18,FGF17,FGFBP2,FGFR2,FGF6,FGF4,FGF1,FGF22,FGF10,FGF20,FGF3
R-HSA-6788467	IL-6-type cytokine receptor ligand interactions	0.281425426037664	-1.26788778288379	20	19	0.00210316581802081	9034	10285	3716,3590,9180,3572,3592,10148,1270,9466,246778,3977,3717,3595,1489,7297,5008,23529,1271,9244,3976	JAK1,IL11RA,OSMR,IL6ST,IL12A,EBI3,CNTF,IL27RA,IL27,LIFR,JAK2,IL12RB2,CTF1,TYK2,OSM,CLCF1,CNTFR,CRLF1,LIF
R-HSA-194223	HDL-mediated lipid transport	0.281425426037664	-1.26788778288379	20	19	0.00210316581802081	9034	10285	3069,8029,344,81693,19,5567,335,213,2,1071,348,345,5360,9619,5568,5566,949,29801,649	HDLBP,CUBN,APOC2,AMN,ABCA1,PRKACB,APOA1,ALB,A2M,CETP,APOE,APOC3,PLTP,ABCG1,PRKACG,PRKACA,SCARB1,ZDHHC8,BMP1
R-HSA-5693538	Homology Directed Repair	0.281635872790177	-1.2671402736419	138	124	0.0137259242860306	9034	10285	8347,9577,8345,51750,8361,80010,8346,83695,3017,8368,7311,10721,5983,116028,6613,146956,7158,2072,197342,5890,6118,10635,7336,5111,5981,6233,8340,8363,8970,7314,4683,6119,7468,8364,57804,11073,472,51426,5429,675,5531,5892,9656,2067,84142,25,151987,641,79728,5424,142,5810,8924,144715,51720,54962,5984,9156,672,8914,84464,7316,8365,3018,8367,5883,9025,8370,8341,1017,348654,54107,6047,7156,1763,7329,121504,8366,51588,8348,10524,545,5985,5888,3364,7516,5893,5427,10111,165918,4361,56655,7517,7515,8360,8339,6117,83990,8343,84126,8290,5889,63967,10038,8359,7486,5982,29086,1111,51548,8344,10714,3980,890,2237,7334,5884,8349,7341,23514,8362,580,128312,8900	H2BC4,BABAM2,H2BC9,RTEL1,H4C6,RMI1,H2BC10,RHNO1,H2BC5,H4C13,UBA52,POLQ,RFC3,RMI2,SUMO2,EME1,TP53BP1,ERCC4,EME2,RAD51B,RPA2,RAD51AP1,UBE2V2,PCNA,RFC1,RPS27A,H2BC13,H4C11,H2BC11,UBB,NBN,RPA3,NSD2,H4C3,POLD4,TOPBP1,ATM,POLK,POLH,BRCA2,PPP4C,RAD51D,MDC1,ERCC1,ABRAXAS1,ABL1,PPP4R2,BLM,PALB2,POLD1,PARP1,RAD1,HERC2,RAD9B,UIMC1,TIPIN,RFC4,EXO1,BRCA1,TIMELESS,SLX4,UBC,H4C8,H2BC3,H4C5,RAD9A,RNF8,H4C14,H2BC15,CDK2,GEN1,POLE3,RNF4,TOP3A,DNA2,UBE2I,H4C16,H4C2,PIAS4,H2BC17,KAT5,ATR,RFC5,RAD51,HUS1,XRCC2,RAD52,POLE2,RAD50,RNF168,MRE11,POLE4,XRCC3,XRCC1,H4C4,H2BC8,RPA1,BRIP1,H2BC7,ATRIP,H3-4,RAD51C,CLSPN,PARP2,H4C1,WRN,RFC2,BABAM1,CHEK1,SIRT6,H2BC6,POLD3,LIG3,CCNA2,FEN1,UBE2N,RAD17,H2BC21,SUMO1,SPIDR,H4C12,BARD1,H2BC26,CCNA1
R-HSA-5358351	Signaling by Hedgehog	0.281635872790177	-1.2671402736419	138	124	0.0137259242860306	9034	10285	112,8100,5710,143471,23198,7316,7979,5692,57758,10197,9491,122706,114,115,7415,22873,54903,6608,50846,5573,10956,6868,55764,5701,5717,2121,5682,23322,5715,27152,5708,8945,51098,5568,9861,5685,5687,108,5690,113,8454,11127,5686,6469,57539,8650,55081,374654,57728,109,107,5695,6400,25989,64750,5696,83737,51684,5704,6500,156,1452,79577,5576,9978,5713,408,5699,80199,5034,7311,5700,5575,84447,23288,55811,5577,5684,57154,2778,64399,5567,6233,2619,5707,3549,196883,5718,409,5566,5706,9742,26160,23432,132884,5711,55733,5694,91653,7314,5719,5727,8405,79659,5702,2262,7289,84455,5693,2736,79809,5714,2932,5691,147111,2735,10213,2737,111,5720,8452,5698,339745,50937	ADCY6,IFT88,PSMD4,PSMA8,PSME4,UBC,SEM1,PSMB4,SCUBE2,PSME3,PSMF1,PSMB11,ADCY8,ADCY9,VCP,DZIP1,MKS1,SMO,DHH,PRKAR1A,OS9,ADAM17,IFT122,PSMC2,PSMD11,EVC,PSMA1,RPGRIP1L,PSMD9,INTU,PSMD2,BTRC,IFT52,PRKACG,PSMD6,PSMA4,PSMA6,ADCY2,PSMB2,ADCY7,CUL1,KIF3A,PSMA5,SHH,WDR35,NUMB,IFT57,KIF7,WDR19,ADCY3,ADCY1,PSMB7,SEL1L,ULK3,SMURF2,PSMB8,ITCH,SUFU,PSMC4,SKP1,GRK2,CSNK1A1,CDC73,PRKAR2A,RBX1,PSMD7,ARRB1,PSMB10,FUZ,P4HB,UBA52,PSMC1,PRKAR1B,SYVN1,IQCE,ADCY10,PRKAR2B,PSMA3,SMURF1,GNAS,HHIP,PRKACB,RPS27A,GAS1,PSMD1,IHH,ADCY4,PSMD12,ARRB2,PRKACA,PSMC6,IFT140,IFT172,GPR161,EVC2,PSMD5,HHAT,PSMB6,BOC,UBB,PSMD13,PTCH1,SPOP,DYNC2H1,PSMC3,GPC5,TULP3,EFCAB7,PSMB5,GLI2,TTC21B,PSMD8,GSK3B,PSMB3,NOTUM,GLI1,PSMD14,GLI3,ADCY5,PSME1,CUL3,PSMB9,SPOPL,CDON
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	0.284855890415964	-1.25577187425966	39	36	0.00398494576046048	9034	10285	6725,2534,5336,805,2885,80228,100616453,7220,930,84876,29760,5293,801,3708,6786,5335,867,7409,808,933,5295,3710,640,6464,4067,6850,974,10768,4690,118788,27071,3709,6654,5777,973,868	SRMS,FYN,PLCG2,CALM2,GRB2,ORAI2,MIR4687,TRPC1,CD19,ORAI1,BLNK,PIK3CD,CALM1,ITPR1,STIM1,PLCG1,CBL,VAV1,CALM3,CD22,PIK3R1,ITPR3,BLK,SHC1,LYN,SYK,CD79B,AHCYL1,NCK1,PIK3AP1,DAPP1,ITPR2,SOS1,PTPN6,CD79A,CBLB
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	0.289829060464886	-1.23846397646641	48	44	0.00487048926278503	9034	10285	5664,1175,1944,2049,2042,7074,7410,1212,1969,2044,8218,4067,1173,83464,1942,1949,163,4318,285220,102,7525,10451,2534,1948,1211,23385,2043,2051,1946,161,1213,2050,4313,5879,2047,2045,51107,1759,1943,160,2048,2046,284656,6714	PSEN2,AP2S1,EFNA3,EPHB3,EPHA3,TIAM1,VAV2,CLTB,EPHA2,EPHA5,CLTCL1,LYN,AP2M1,APH1B,EFNA1,EFNB3,AP2B1,MMP9,EPHA6,ADAM10,YES1,VAV3,FYN,EFNB2,CLTA,NCSTN,EPHA4,EPHB6,EFNA5,AP2A2,CLTC,EPHB4,MMP2,RAC1,EPHB1,EPHA7,APH1A,DNM1,EFNA2,AP2A1,EPHB2,EPHA8,EPHA10,SRC
R-HSA-392451	G beta:gamma signalling through PI3Kgamma	0.289829060464886	-1.23846397646641	48	44	0.00487048926278503	9034	10285	3718,2885,3716,208,2782,3567,59345,3568,5170,5293,10000,10681,3717,5290,387,51764,5291,2784,3558,5295,6464,23533,2792,207,1439,94235,8503,5296,55970,3560,54331,2783,3559,146850,2791,1437,2793,2788,2786,2790,5294,9846,2787,3562	JAK3,GRB2,JAK1,AKT2,GNB1,IL5,GNB4,IL5RA,PDPK1,PIK3CD,AKT3,GNB5,JAK2,PIK3CA,RHOA,GNG13,PIK3CB,GNB3,IL2,PIK3R1,SHC1,PIK3R5,GNGT1,AKT1,CSF2RB,GNG8,PIK3R3,PIK3R2,GNG12,IL2RB,GNG2,GNB2,IL2RA,PIK3R6,GNG11,CSF2,GNGT2,GNG7,GNG4,GNG10,PIK3CG,GAB2,GNG5,IL3
R-HSA-168176	Toll Like Receptor 5 (TLR5) Cascade	0.292357805845438	-1.22977686437335	84	76	0.00841266327208324	9034	10285	7335,5608,8945,5970,177,5519,3725,1147,5606,5601,4792,5528,23291,6885,6233,1849,10392,3146,351,9252,81793,5595,4208,7311,5600,1660,57161,7316,4615,5598,4205,3656,6500,5604,1326,51135,7100,1386,6196,6283,23118,1432,3551,1385,4790,5599,4793,6195,2353,7334,7189,8767,6416,246330,5518,10454,7867,5516,8454,4791,6288,9261,5609,5602,57162,1848,51231,5594,79155,4214,5515,51295,466,7314,1846,64127	UBE2V1,MAP2K6,BTRC,RELA,AGER,PPP2R1B,JUN,CHUK,MAP2K3,MAPK9,NFKBIA,PPP2R5D,FBXW11,MAP3K7,RPS27A,DUSP7,NOD1,HMGB1,APP,RPS6KA5,TLR10,MAPK3,MEF2C,UBA52,MAPK11,DHX9,PELI2,UBC,MYD88,MAPK7,MEF2A,IRAK2,SKP1,MAP2K1,MAP3K8,IRAK4,TLR5,ATF2,RPS6KA2,S100A12,TAB2,MAPK14,IKBKB,CREB1,NFKB1,MAPK8,NFKBIB,RPS6KA1,FOS,UBE2N,TRAF6,RIPK2,MAP2K4,PELI3,PPP2R1A,TAB1,MAPKAPK3,PPP2CB,CUL1,NFKB2,SAA1,MAPKAPK2,MAP2K7,MAPK10,PELI1,DUSP6,VRK3,MAPK1,TNIP2,MAP3K1,PPP2CA,ECSIT,ATF1,UBB,DUSP4,NOD2
R-HSA-168142	Toll Like Receptor 10 (TLR10) Cascade	0.292357805845438	-1.22977686437335	84	76	0.00841266327208324	9034	10285	23118,6283,6196,1432,1326,6500,5604,7100,1386,51135,6195,4793,5599,7334,2353,4790,3551,1385,6288,4791,8454,5516,5602,5609,9261,246330,8767,6416,7189,7867,10454,5518,51295,5515,4214,79155,1846,64127,7314,466,1848,57162,5594,51231,1147,3725,5519,5606,5608,7335,177,5970,8945,6885,23291,3146,1849,10392,6233,5601,5528,4792,4208,5595,81793,1660,5600,7311,351,9252,3656,4615,7316,57161,4205,5598	TAB2,S100A12,RPS6KA2,MAPK14,MAP3K8,SKP1,MAP2K1,TLR5,ATF2,IRAK4,RPS6KA1,NFKBIB,MAPK8,UBE2N,FOS,NFKB1,IKBKB,CREB1,SAA1,NFKB2,CUL1,PPP2CB,MAPK10,MAP2K7,MAPKAPK2,PELI3,RIPK2,MAP2K4,TRAF6,MAPKAPK3,TAB1,PPP2R1A,ECSIT,PPP2CA,MAP3K1,TNIP2,DUSP4,NOD2,UBB,ATF1,DUSP6,PELI1,MAPK1,VRK3,CHUK,JUN,PPP2R1B,MAP2K3,MAP2K6,UBE2V1,AGER,RELA,BTRC,MAP3K7,FBXW11,HMGB1,DUSP7,NOD1,RPS27A,MAPK9,PPP2R5D,NFKBIA,MEF2C,MAPK3,TLR10,DHX9,MAPK11,UBA52,APP,RPS6KA5,IRAK2,MYD88,UBC,PELI2,MEF2A,MAPK7
R-HSA-975871	MyD88 cascade initiated on plasma membrane	0.292357805845438	-1.22977686437335	84	76	0.00841266327208324	9034	10285	4791,8454,6288,5516,5609,5602,9261,8767,6416,246330,7189,10454,7867,5518,5515,51295,79155,4214,1846,64127,466,7314,1848,57162,51231,5594,23118,6196,6283,1432,1326,5604,6500,51135,1386,7100,4793,6195,5599,7334,2353,1385,3551,4790,5595,4208,81793,5600,1660,7311,351,9252,3656,4615,7316,57161,5598,4205,3725,1147,5519,5606,7335,5608,177,8945,5970,23291,6885,1849,3146,10392,6233,5601,5528,4792	NFKB2,CUL1,SAA1,PPP2CB,MAP2K7,MAPK10,MAPKAPK2,RIPK2,MAP2K4,PELI3,TRAF6,TAB1,MAPKAPK3,PPP2R1A,PPP2CA,ECSIT,TNIP2,MAP3K1,DUSP4,NOD2,ATF1,UBB,DUSP6,PELI1,VRK3,MAPK1,TAB2,RPS6KA2,S100A12,MAPK14,MAP3K8,MAP2K1,SKP1,IRAK4,ATF2,TLR5,NFKBIB,RPS6KA1,MAPK8,UBE2N,FOS,CREB1,IKBKB,NFKB1,MAPK3,MEF2C,TLR10,MAPK11,DHX9,UBA52,APP,RPS6KA5,IRAK2,MYD88,UBC,PELI2,MAPK7,MEF2A,JUN,CHUK,PPP2R1B,MAP2K3,UBE2V1,MAP2K6,AGER,BTRC,RELA,FBXW11,MAP3K7,DUSP7,HMGB1,NOD1,RPS27A,MAPK9,PPP2R5D,NFKBIA
R-HSA-5654738	Signaling by FGFR2	0.293104552067025	-1.22722590062156	75	68	0.00752711976975869	9034	10285	5516,3845,2249,2885,5518,8822,5725,5515,867,5290,8817,5430,7314,9982,100616459,143282,5781,2254,5433,5594,5335,7073,5295,6464,6714,10253,22916,83888,5431,2963,2252,80004,4670,8074,4686,54845,5595,10818,23543,26281,7311,3178,27006,2255,10817,2251,2263,4893,5439,5432,7316,5440,5441,2248,3265,2549,2246,7072,6654,673,2250,6233,2247,2253,5434,3187,2962,3185	PPP2CB,KRAS,FGF4,GRB2,PPP2R1A,FGF17,PTBP1,PPP2CA,CBL,PIK3CA,FGF18,POLR2A,UBB,FGFBP1,MIR4745,FGFBP3,PTPN11,FGF9,POLR2D,MAPK1,PLCG1,TIAL1,PIK3R1,SHC1,SRC,SPRY2,NCBP2,FGFBP2,POLR2B,GTF2F2,FGF7,ESRP2,HNRNPM,FGF23,NCBP1,ESRP1,MAPK3,FRS2,RBFOX2,FGF20,UBA52,HNRNPA1,FGF22,FGF10,FRS3,FGF6,FGFR2,NRAS,POLR2J,POLR2C,UBC,POLR2K,POLR2L,FGF3,HRAS,GAB1,FGF1,TIA1,SOS1,BRAF,FGF5,RPS27A,FGF2,FGF8,POLR2E,HNRNPH1,GTF2F1,HNRNPF
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	0.293104552067025	-1.22722590062156	75	68	0.00752711976975869	9034	10285	3018,8365,8367,9025,8370,8341,9577,8347,7157,8345,7316,8361,322,8366,121504,7311,8348,51588,2140,7158,10524,8346,2139,3017,8368,7329,6233,9682,7336,8360,8339,8343,8970,8314,8340,8467,8363,165918,10111,4361,7314,8359,4683,8290,29086,23030,472,8344,7468,8364,9031,7334,5599,11200,2070,9656,84142,25,580,8362,5536,2138,128312,672,8349,8924,7341,51720	H2BC3,H4C8,H4C5,RNF8,H4C14,H2BC15,BABAM2,H2BC4,TP53,H2BC9,UBC,H4C6,APBB1,H4C2,H4C16,UBA52,H2BC17,PIAS4,EYA3,TP53BP1,KAT5,H2BC10,EYA2,H2BC5,H4C13,UBE2I,RPS27A,KDM4A,UBE2V2,H4C4,H2BC8,H2BC7,H2BC11,BAP1,H2BC13,SMARCA5,H4C11,RNF168,RAD50,MRE11,UBB,H4C1,NBN,H3-4,BABAM1,KDM4B,ATM,H2BC6,NSD2,H4C3,BAZ1B,UBE2N,MAPK8,CHEK2,EYA4,MDC1,ABRAXAS1,ABL1,BARD1,H4C12,PPP5C,EYA1,H2BC26,BRCA1,H2BC21,HERC2,SUMO1,UIMC1
R-HSA-202040	G-protein activation	0.297367383826632	-1.21278692203081	29	27	0.00298870932034536	9034	10285	5443,5173,51764,2771,2791,59345,4988,406974,10681,2780,2782,2783,346562,55970,2787,54331,94235,2781,2786,2792,2779,2790,2770,2793,2773,2784,2788	POMC,PDYN,GNG13,GNAI2,GNG11,GNB4,OPRM1,MIR197,GNB5,GNAT2,GNB1,GNB2,GNAT3,GNG12,GNG5,GNG2,GNG8,GNAZ,GNG4,GNGT1,GNAT1,GNG10,GNAI1,GNGT2,GNAI3,GNB3,GNG7
R-HSA-5654732	Negative regulation of FGFR3 signaling	0.297367383826632	-1.21278692203081	29	27	0.00298870932034536	9034	10285	5516,5595,10818,7311,26281,2249,5518,2885,8817,5515,867,8822,7314,2254,5781,7316,5594,6714,2246,10253,673,6233,2250,2253,8074,2247,2261	PPP2CB,MAPK3,FRS2,UBA52,FGF20,FGF4,PPP2R1A,GRB2,FGF18,PPP2CA,CBL,FGF17,UBB,FGF9,PTPN11,UBC,MAPK1,SRC,FGF1,SPRY2,BRAF,RPS27A,FGF5,FGF8,FGF23,FGF2,FGFR3
R-HSA-196807	Nicotinate metabolism	0.297367383826632	-1.21278692203081	29	27	0.00298870932034536	9034	10285	349565,10135,160728,23475,84875,952,55191,683,56965,128240,9390,4837,65220,55739,83594,54625,143,5740,54956,5743,64802,23057,4907,1582,27231,83666,54981	NMNAT3,NAMPT,SLC5A8,QPRT,PARP10,CD38,NADSYN1,BST1,PARP6,NAXE,SLC22A13,NNMT,NADK,NAXD,NUDT12,PARP14,PARP4,PTGIS,PARP16,PTGS2,NMNAT1,NMNAT2,NT5E,CYP8B1,NMRK2,PARP9,NMRK1
R-HSA-3299685	Detoxification of Reactive Oxygen Species	0.304607607802984	-1.18873086246074	38	35	0.00387425282266991	9034	10285	54205,2877,475,50507,9588,6649,257202,2880,2882,9973,10587,343,2876,847,2878,4688,493869,6648,2950,10935,7296,5034,25828,1535,30001,4689,25824,2936,5052,318,7295,79400,653361,7001,6647	CYCS,GPX2,ATOX1,NOX4,PRDX6,SOD3,GPX6,GPX5,GPX7,CCS,TXNRD2,AQP8,GPX1,CAT,GPX3,NCF2,GPX8,SOD2,GSTP1,PRDX3,TXNRD1,P4HB,TXN2,CYBA,ERO1A,NCF4,PRDX5,GSR,PRDX1,NUDT2,TXN,NOX5,NCF1,PRDX2,SOD1
R-HSA-6802957	Oncogenic MAPK signaling	0.30766056059741	-1.17875817972328	74	67	0.00741642683196812	9034	10285	408,64926,10256,80853,153090,9061,4893,54845,5595,8087,23499,2243,10142,2335,9715,409,8826,5921,673,57670,3690,5605,283455,11044,8546,56829,2266,3265,7529,27044,23164,1445,100847012,3674,5037,4140,5594,5245,3717,5894,22906,7450,9462,5922,4296,5906,8805,3845,5908,4763,57085,8831,8315,55750,10533,10827,54518,7414,5604,10156,8437,9444,55109,6714,2244,10018,4000	ARRB1,RASAL3,CNKSR1,KDM7A,DAB2IP,PAPSS1,NRAS,ESRP1,MAPK3,FXR1,MACF1,FGA,AKAP9,FN1,FAM131B,ARRB2,IQGAP1,RASA1,BRAF,KIAA1549,ITGB3,MAP2K2,KSR2,TENT4A,AP3B1,ZC3HAV1,FGG,HRAS,YWHAB,SND1,MPRIP,CSK,MIR5004,ITGA2B,PEBP1,MARK3,MAPK1,PHB1,JAK2,RAF1,TRAK1,VWF,RASAL2,RASA2,MAP3K11,RAP1A,TRIM24,KRAS,RAP1B,NF1,AGTRAP,SYNGAP1,BRAP,AGK,ATG7,FAM114A2,APBB1IP,VCL,MAP2K1,RASA4,RASAL1,QKI,AGGF1,SRC,FGB,BCL2L11,LMNA
R-HSA-5576892	Phase 0 - rapid depolarisation	0.307833678603446	-1.17819564639779	47	43	0.00475979632499447	9034	10285	59284,27091,805,6328,2257,6326,781,776,6334,2256,6327,100126325,775,779,93589,808,6323,9254,783,10369,29098,59283,6332,815,817,27092,59285,6331,10368,6335,801,6336,11280,785,784,818,55800,6329,786,816,6330,2259,55799	CACNG7,CACNG5,CALM2,SCN3A,FGF12,SCN2A,CACNA2D1,CACNA1D,SCN8A,FGF11,SCN2B,MIR935,CACNA1C,CACNA1S,CACNA2D4,CALM3,SCN1A,CACNA2D2,CACNB2,CACNG2,RANGRF,CACNG8,SCN7A,CAMK2A,CAMK2D,CACNG4,CACNG6,SCN5A,CACNG3,SCN9A,CALM1,SCN10A,SCN11A,CACNB4,CACNB3,CAMK2G,SCN3B,SCN4A,CACNG1,CAMK2B,SCN4B,FGF14,CACNA2D3
R-HSA-422085	Synthesis, secretion, and deacylation of Ghrelin	0.308674051398022	-1.17546940867464	19	18	0.00199247288023024	9034	10285	7349,590,60559,3479,3952,9314,1395,9789,5122,7941,619373,3630,51738,23478,2641,90701,43,2688	UCN,BCHE,SPCS3,IGF1,LEP,KLF4,CRHR2,SPCS2,PCSK1,PLA2G7,MBOAT4,INS,GHRL,SEC11A,GCG,SEC11C,ACHE,GH1
R-HSA-442660	Na+/Cl- dependent neurotransmitter transporters	0.308674051398022	-1.17546940867464	19	18	0.00199247288023024	9034	10285	6582,6580,6529,340024,6570,348932,6531,9152,55117,54716,6539,6536,6530,6538,6571,6540,6533,6534	SLC22A2,SLC22A1,SLC6A1,SLC6A19,SLC18A1,SLC6A18,SLC6A3,SLC6A5,SLC6A15,SLC6A20,SLC6A12,SLC6A9,SLC6A2,SLC6A11,SLC18A2,SLC6A13,SLC6A6,SLC6A7
R-HSA-442982	Ras activation uopn Ca2+ infux through NMDA receptor	0.308674051398022	-1.17546940867464	19	18	0.00199247288023024	9034	10285	817,805,815,808,1742,2906,818,3265,2903,2904,5923,5924,88,801,816,2905,10142,4747	CAMK2D,CALM2,CAMK2A,CALM3,DLG4,GRIN2D,CAMK2G,HRAS,GRIN2A,GRIN2B,RASGRF1,RASGRF2,ACTN2,CALM1,CAMK2B,GRIN2C,AKAP9,NEFL
R-HSA-888590	GABA synthesis, release, reuptake and degradation	0.308674051398022	-1.17546940867464	19	18	0.00199247288023024	9034	10285	6616,140679,6529,2571,18,5864,80331,3312,10815,7915,6539,6844,6812,22999,2572,6538,6540,6857	SNAP25,SLC32A1,SLC6A1,GAD1,ABAT,RAB3A,DNAJC5,HSPA8,CPLX1,ALDH5A1,SLC6A12,VAMP2,STXBP1,RIMS1,GAD2,SLC6A11,SLC6A13,SYT1
R-HSA-71403	Citric acid cycle (TCA cycle)	0.308674051398022	-1.17546940867464	19	18	0.00199247288023024	9034	10285	3418,8801,2271,1738,1743,23530,6392,6390,3419,6389,8803,6391,1431,4191,4967,50,8802,3420	IDH2,SUCLG2,FH,DLD,DLST,NNT,SDHD,SDHB,IDH3A,SDHA,SUCLA2,SDHC,CS,MDH2,OGDH,ACO2,SUCLG1,IDH3B
R-HSA-392851	Prostacyclin signalling through prostacyclin receptor	0.308674051398022	-1.17546940867464	19	18	0.00199247288023024	9034	10285	2792,2790,2786,2782,2783,2784,2788,2778,2793,54331,51764,5739,2787,55970,10681,2791,94235,59345	GNGT1,GNG10,GNG4,GNB1,GNB2,GNB3,GNG7,GNAS,GNGT2,GNG2,GNG13,PTGIR,GNG5,GNG12,GNB5,GNG11,GNG8,GNB4
R-HSA-156584	Cytosolic sulfonation of small molecules	0.308674051398022	-1.17546940867464	19	18	0.00199247288023024	9034	10285	6783,9060,100616124,6819,6799,1836,27233,10861,10380,6820,6822,347734,27284,6817,84836,51000,9061,25830	SULT1E1,PAPSS2,MIR4647,SULT1C2,SULT1A2,SLC26A2,SULT1C4,SLC26A1,BPNT1,SULT2B1,SULT2A1,SLC35B2,SULT1B1,SULT1A1,ABHD14B,SLC35B3,PAPSS1,SULT4A1
R-HSA-5578775	Ion homeostasis	0.308897250336049	-1.17474658056679	56	51	0.00564533982731902	9034	10285	818,483,5349,3710,477,816,493,10060,4842,6263,490,481,815,817,6261,478,491,480,84876,3708,801,6786,476,808,486,2281,6588,6547,5566,10768,6717,444,482,488,6262,3709,6546,3767,5348,53828,805,1760,80228,100616453,7220,10345,489,487,53826,6543,5350	CAMK2G,ATP1B3,FXYD3,ITPR3,ATP1A2,CAMK2B,ATP2B4,ABCC9,NOS1,RYR3,ATP2B1,ATP1B1,CAMK2A,CAMK2D,RYR1,ATP1A3,ATP2B2,ATP1A4,ORAI1,ITPR1,CALM1,STIM1,ATP1A1,CALM3,FXYD2,FKBP1B,SLN,SLC8A3,PRKACA,AHCYL1,SRI,ASPH,ATP1B2,ATP2A2,RYR2,ITPR2,SLC8A1,KCNJ11,FXYD1,FXYD4,CALM2,DMPK,ORAI2,MIR4687,TRPC1,TRDN,ATP2A3,ATP2A1,FXYD6,SLC8A2,PLN
R-HSA-2142816	Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	1579,1544,1543,1559,1557,113612,8529,1545,1558	CYP4A11,CYP1A2,CYP1A1,CYP2C9,CYP2C19,CYP2U1,CYP4F2,CYP1B1,CYP2C8
R-HSA-629597	Highly calcium permeable nicotinic acetylcholine receptors	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	1137,8973,1136,1143,1141,1135,1142,1138,1134	CHRNA4,CHRNA6,CHRNA3,CHRNB4,CHRNB2,CHRNA2,CHRNB3,CHRNA5,CHRNA1
R-HSA-2179392	EGFR Transactivation by Gastrin	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	5578,2885,4893,4314,1956,1839,3265,6654,3845	PRKCA,GRB2,NRAS,MMP3,EGFR,HBEGF,HRAS,SOS1,KRAS
R-HSA-1300642	Sperm Motility And Taxes	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	79820,117144,84329,157855,347732,117155,257062,378807,57828	CATSPERB,CATSPER1,HVCN1,KCNU1,CATSPER3,CATSPER2,CATSPERD,CATSPER4,CATSPERG
R-HSA-196025	Formation of annular gap junctions	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	1601,1213,1211,1759,1212,8218,1785,2697,1173	DAB2,CLTC,CLTA,DNM1,CLTB,CLTCL1,DNM2,GJA1,AP2M1
R-HSA-2428933	SHC-related events triggered by IGF1R	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	3265,3480,6654,3479,6464,3845,2885,4893,3481	HRAS,IGF1R,SOS1,IGF1,SHC1,KRAS,GRB2,NRAS,IGF2
R-HSA-391908	Prostanoid ligand receptors	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	5737,5732,5739,5729,6915,11251,5733,5734,5731	PTGFR,PTGER2,PTGIR,PTGDR,TBXA2R,PTGDR2,PTGER3,PTGER4,PTGER1
R-HSA-112411	MAPK1 (ERK2) activation	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	3570,3572,3717,3716,5605,3569,7297,5781,5594	IL6R,IL6ST,JAK2,JAK1,MAP2K2,IL6,TYK2,PTPN11,MAPK1
R-HSA-428890	Role of Abl in Robo-Slit signaling	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	27,2817,25,10486,9353,23332,6091,23122,10487	ABL2,GPC1,ABL1,CAP2,SLIT2,CLASP1,ROBO1,CLASP2,CAP1
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	79872,1499,1500,6714,6233,7311,7314,7316,999	CBLL1,CTNNB1,CTNND1,SRC,RPS27A,UBA52,UBB,UBC,CDH1
R-HSA-193697	p75NTR regulates axonogenesis	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	84894,387,4099,57142,396,4804,4803,4974,9138	LINGO1,RHOA,MAG,RTN4,ARHGDIA,NGFR,NGF,OMG,ARHGEF1
R-HSA-8854691	Interleukin-19, 20, 22, 24	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	116379,58985,3588,11009,53832,53833,50616,50604,29949	IL22RA2,IL22RA1,IL10RB,IL24,IL20RA,IL20RB,IL22,IL20,IL19
R-HSA-2243919	Crosslinking of collagen fibrils	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	7092,649,7093,84695,5118,4017,4016,84171,4015	TLL1,BMP1,TLL2,LOXL3,PCOLCE,LOXL2,LOXL1,LOXL4,LOX
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	116985,6233,7311,7314,1796,207,867,5753,7316	ARAP1,RPS27A,UBA52,UBB,DOK1,AKT1,CBL,PTK6,UBC
R-HSA-194002	Glucocorticoid biosynthesis	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	3290,1585,1586,1589,5443,1584,3291,3283,3284	HSD11B1,CYP11B2,CYP17A1,CYP21A2,POMC,CYP11B1,HSD11B2,HSD3B1,HSD3B2
R-HSA-75094	Formation of the Editosome	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	164668,9582,29974,100913187,339,27350,403314,10930,200315	APOBEC3H,APOBEC3B,A1CF,APOBEC3A_B,APOBEC1,APOBEC3C,APOBEC4,APOBEC2,APOBEC3A
R-HSA-2142688	Synthesis of 5-eicosatetraenoic acids	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	4056,5444,241,240,5445,5446,2879,2876,2877	LTC4S,PON1,ALOX5AP,ALOX5,PON2,PON3,GPX4,GPX1,GPX2
R-HSA-2214320	Anchoring fibril formation	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	3909,7092,100313843,1294,100422894,3918,649,7093,3914	LAMA3,TLL1,MIR711,COL7A1,MIR4260,LAMC2,BMP1,TLL2,LAMB3
R-HSA-390696	Adrenoceptors	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	151,150,155,153,147,152,148,146,154	ADRA2B,ADRA2A,ADRB3,ADRB1,ADRA1B,ADRA2C,ADRA1A,ADRA1D,ADRB2
R-HSA-72200	mRNA Editing: C to U Conversion	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	9582,164668,10930,403314,200315,339,29974,100913187,27350	APOBEC3B,APOBEC3H,APOBEC2,APOBEC4,APOBEC3A,APOBEC1,A1CF,APOBEC3A_B,APOBEC3C
R-HSA-162592	Integration of provirus	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	8815,7520,3981,11168,3159,7518,2547,3836,5478	BANF1,XRCC5,LIG4,PSIP1,HMGA1,XRCC4,XRCC6,KPNA1,PPIA
R-HSA-447041	CHL1 interactions	0.311079565699997	-1.16770656126027	9	9	0.000996236440115121	9034	10285	8829,3672,10752,286,3673,8515,27255,3688,3312	NRP1,ITGA1,CHL1,ANK1,ITGA2,ITGA10,CNTN6,ITGB1,HSPA8
R-HSA-354192	Integrin alphaIIb beta3 signaling	0.320739620739951	-1.1371256353554	28	26	0.00287801638255479	9034	10285	2885,5906,11069,5747,5908,5770,2243,1398,10411,3674,5170,1445,7450,10125,10235,54518,6464,2266,2244,6714,6850,207,2335,6654,9564,3690	GRB2,RAP1A,RAPGEF4,PTK2,RAP1B,PTPN1,FGA,CRK,RAPGEF3,ITGA2B,PDPK1,CSK,VWF,RASGRP1,RASGRP2,APBB1IP,SHC1,FGG,FGB,SRC,SYK,AKT1,FN1,SOS1,BCAR1,ITGB3
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	0.320739620739951	-1.1371256353554	28	26	0.00287801638255479	9034	10285	27124,84812,5335,801,5331,3706,3633,5728,805,5336,3705,3707,23007,122618,8867,3635,23236,808,51196,5330,80271,5332,5333,3636,9651,89869	INPP5J,PLCD4,PLCG1,CALM1,PLCB3,ITPKA,INPP5B,PTEN,CALM2,PLCG2,ITPK1,ITPKB,PLCH1,PLD4,SYNJ1,INPP5D,PLCB1,CALM3,PLCE1,PLCB2,ITPKC,PLCB4,PLCD1,INPPL1,PLCH2,PLCZ1
R-HSA-5357769	Caspase activation via extrinsic apoptotic signalling pathway	0.320739620739951	-1.1371256353554	28	26	0.00287801638255479	9034	10285	1630,7098,353376,90249,8772,8737,929,842,355,148022,1612,23604,841,693222,8717,7099,1613,356,8837,26060,23643,8797,219699,8743,8795,836	DCC,TLR3,TICAM2,UNC5A,FADD,RIPK1,CD14,CASP9,FAS,TICAM1,DAPK1,DAPK2,CASP8,MIR637,TRADD,TLR4,DAPK3,FASLG,CFLAR,APPL1,LY96,TNFRSF10A,UNC5B,TNFSF10,TNFRSF10B,CASP3
R-HSA-264876	Insulin processing	0.320739620739951	-1.1371256353554	28	26	0.00287801638255479	9034	10285	64924,55676,1363,23265,169026,3798,1369,5126,56605,10640,3630,55763,30001,149371,54536,3800,6844,11336,5873,3799,55770,5122,25924,148867,60412,4644	SLC30A5,SLC30A6,CPE,EXOC7,SLC30A8,KIF5A,CPN1,PCSK2,ERO1B,EXOC5,INS,EXOC1,ERO1A,EXOC8,EXOC6,KIF5C,VAMP2,EXOC3,RAB27A,KIF5B,EXOC2,PCSK1,MYRIP,SLC30A7,EXOC4,MYO5A
R-HSA-174800	Chylomicron-mediated lipid transport	0.320739620739951	-1.1371256353554	28	26	0.00287801638255479	9034	10285	337,344,335,51128,3949,116519,348,8720,63924,26291,27329,5045,338,3990,338328,84699,5046,55908,5034,336,4547,26119,4023,5125,51129,345	APOA4,APOC2,APOA1,SAR1B,LDLR,APOA5,APOE,MBTPS1,CIDEC,FGF21,ANGPTL3,FURIN,APOB,LIPC,GPIHBP1,CREB3L3,PCSK6,ANGPTL8,P4HB,APOA2,MTTP,LDLRAP1,LPL,PCSK5,ANGPTL4,APOC3
R-HSA-69481	G2/M Checkpoints	0.320875158352336	-1.13670314628932	169	151	0.0167146336063759	9034	10285	5692,121504,8366,51588,9491,8348,10197,10524,9088,51512,1017,7156,122706,1763,7531,23594,8365,3018,5883,8367,9025,143471,5710,8370,8341,23198,7157,7979,7316,4172,7529,8360,5717,8339,5715,6117,5682,8343,83990,5708,10111,165918,4361,9861,3364,5701,9133,7533,545,5985,29086,5690,1111,5686,8344,10926,5982,983,4175,7465,7486,5685,8359,5687,84126,8290,5000,7534,63967,5696,8362,580,128312,8349,5704,7341,7334,5884,5695,8317,84515,5699,5983,7311,116028,5700,7158,8346,5684,83695,3017,8368,2810,4174,9577,8347,5713,8345,55388,8361,80010,5706,8970,8340,5711,8363,5694,995,6233,5707,5718,4998,6118,7336,472,5702,7468,8364,5693,11073,7314,4999,5719,23595,4683,6119,993,4171,10213,5984,5001,9156,5720,672,5810,8318,8924,144715,5698,990,891,51720,4173,10971,7532,641,11200,5714,84142,9656,5691	PSMB4,H4C16,H4C2,PIAS4,PSMF1,H2BC17,PSME3,KAT5,PKMYT1,GTSE1,CDK2,TOP3A,PSMB11,DNA2,YWHAE,ORC6,H4C8,H2BC3,RAD9A,H4C5,RNF8,PSMA8,PSMD4,H4C14,H2BC15,PSME4,TP53,SEM1,UBC,MCM3,YWHAB,H4C4,PSMD11,H2BC8,PSMD9,RPA1,PSMA1,H2BC7,BRIP1,PSMD2,RAD50,RNF168,MRE11,PSMD6,HUS1,PSMC2,CCNB2,YWHAH,ATR,RFC5,BABAM1,PSMB2,CHEK1,PSMA5,H2BC6,DBF4,RFC2,CDK1,MCM6,WEE1,WRN,PSMA4,H4C1,PSMA6,ATRIP,H3-4,ORC4,YWHAZ,CLSPN,PSMB8,H4C12,BARD1,H2BC26,H2BC21,PSMC4,SUMO1,UBE2N,RAD17,PSMB7,CDC7,MCM8,PSMB10,RFC3,UBA52,RMI2,PSMC1,TP53BP1,H2BC10,PSMA3,RHNO1,H2BC5,H4C13,SFN,MCM5,BABAM2,H2BC4,PSMD7,H2BC9,MCM10,H4C6,RMI1,PSMC6,H2BC11,H2BC13,PSMD5,H4C11,PSMB6,CDC25C,RPS27A,PSMD1,PSMD12,ORC1,RPA2,UBE2V2,ATM,PSMC3,NSD2,H4C3,PSMB5,TOPBP1,UBB,ORC2,PSMD13,ORC3,NBN,RPA3,CDC25A,MCM2,PSMD14,RFC4,ORC5,EXO1,PSME1,BRCA1,RAD1,CDC45,HERC2,RAD9B,PSMB9,CDC6,CCNB1,UIMC1,MCM4,YWHAQ,YWHAG,BLM,CHEK2,PSMD8,ABRAXAS1,MDC1,PSMB3
R-HSA-73884	Base Excision Repair	0.325320633183877	-1.12294401934377	37	34	0.00376355988487934	9034	10285	142,5424,56655,5984,7515,79661,6117,4350,10714,6118,4595,5985,3980,5981,5111,2237,252969,3978,5427,4913,8505,11284,54107,5423,57804,5982,4968,5983,7374,23583,10038,6996,6119,8930	PARP1,POLD1,POLE4,RFC4,XRCC1,NEIL1,RPA1,MPG,POLD3,RPA2,MUTYH,RFC5,LIG3,RFC1,PCNA,FEN1,NEIL2,LIG1,POLE2,NTHL1,PARG,PNKP,POLE3,POLB,POLD4,RFC2,OGG1,RFC3,UNG,SMUG1,PARP2,TDG,RPA3,MBD4
R-HSA-73933	Resolution of Abasic Sites (AP sites)	0.325320633183877	-1.12294401934377	37	34	0.00376355988487934	9034	10285	5427,3978,5981,252969,5111,2237,5985,3980,6118,4595,10714,4350,6117,79661,5984,7515,56655,142,5424,6119,8930,6996,10038,23583,5983,7374,57804,5982,4968,4913,54107,5423,11284,8505	POLE2,LIG1,RFC1,NEIL2,PCNA,FEN1,RFC5,LIG3,RPA2,MUTYH,POLD3,MPG,RPA1,NEIL1,RFC4,XRCC1,POLE4,PARP1,POLD1,RPA3,MBD4,TDG,PARP2,SMUG1,RFC3,UNG,POLD4,RFC2,OGG1,NTHL1,POLE3,POLB,PNKP,PARG
R-HSA-438064	Post NMDA receptor activation events	0.325320633183877	-1.12294401934377	37	34	0.00376355988487934	9034	10285	5566,2904,3265,5924,6196,2906,808,5568,818,5567,109,107,673,6195,814,4747,1385,816,10142,2905,2903,5923,805,817,815,1742,114,6237,84254,5894,88,801,5594,5170	PRKACA,GRIN2B,HRAS,RASGRF2,RPS6KA2,GRIN2D,CALM3,PRKACG,CAMK2G,PRKACB,ADCY3,ADCY1,BRAF,RPS6KA1,CAMK4,NEFL,CREB1,CAMK2B,AKAP9,GRIN2C,GRIN2A,RASGRF1,CALM2,CAMK2D,CAMK2A,DLG4,ADCY8,RRAS,CAMKK1,RAF1,ACTN2,CALM1,MAPK1,PDPK1
R-HSA-5689896	Ovarian tumor domain proteases	0.325320633183877	-1.12294401934377	37	34	0.00376355988487934	9034	10285	55432,54764,57506,161725,7128,100500827,78990,7187,2099,79931,7321,7415,10392,23586,6233,8767,84282,7189,56957,64135,5728,8737,23252,324,7311,7316,7157,79155,55611,10318,64127,387,7314,7706	YOD1,ZRANB1,MAVS,OTUD7A,TNFAIP3,MIR3614,OTUB2,TRAF3,ESR1,TNIP3,UBE2D1,VCP,NOD1,RIGI,RPS27A,RIPK2,RNF135,TRAF6,OTUD7B,IFIH1,PTEN,RIPK1,OTUD3,APC,UBA52,UBC,TP53,TNIP2,OTUB1,TNIP1,NOD2,RHOA,UBB,TRIM25
R-HSA-4615885	SUMOylation of DNA replication proteins	0.326588517549796	-1.11905425659659	46	42	0.0046491033872039	9034	10285	7155,5905,9212,9818,129401,7175,4928,6790,332,9631,81929,9688,55706,8086,11097,79023,6612,8021,9883,7329,51588,4927,6613,55746,57122,5111,53371,9972,23225,79902,23511,348995,7150,23279,7341,3619,10762,7153,5903,23165,100101267,23636	TOP2B,RANGAP1,AURKB,NUP58,NUP35,TPR,NUP98,AURKA,BIRC5,NUP155,SEH1L,NUP93,NDC1,AAAS,NUP42,NUP37,SUMO3,NUP214,POM121,UBE2I,PIAS4,NUP88,SUMO2,NUP133,NUP107,PCNA,NUP54,NUP153,NUP210,NUP85,NUP188,NUP43,TOP1,NUP160,SUMO1,INCENP,NUP50,TOP2A,RANBP2,NUP205,POM121C,NUP62
R-HSA-1839117	Signaling by cytosolic FGFR1 fusion mutants	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	6772,6776,9846,5290,399687,6774,11052,7750,1523,6777,613,2885,26127,11064,8805,5295,9208	STAT1,STAT5A,GAB2,PIK3CA,MYO18A,STAT3,CPSF6,ZMYM2,CUX1,STAT5B,BCR,GRB2,FGFR1OP2,CNTRL,TRIM24,PIK3R1,LRRFIP1
R-HSA-69205	G1/S-Specific Transcription	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	8900,7084,1719,983,6241,7298,990,8318,7029,81620,5111,993,26271,1869,4998,7027,898	CCNA1,TK2,DHFR,CDK1,RRM2,TYMS,CDC6,CDC45,TFDP2,CDT1,PCNA,CDC25A,FBXO5,E2F1,ORC1,TFDP1,CCNE1
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	148022,3661,5781,7316,7187,9641,23643,929,29110,7314,6233,3665,7099,353376,7311,7098,10010	TICAM1,IRF3,PTPN11,UBC,TRAF3,IKBKE,LY96,CD14,TBK1,UBB,RPS27A,IRF7,TLR4,TICAM2,UBA52,TLR3,TANK
R-HSA-210993	Tie2 Signaling	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	9046,5781,7010,284,5290,5296,2888,6654,4893,2885,51378,5291,3845,6464,5295,285,3265	DOK2,PTPN11,TEK,ANGPT1,PIK3CA,PIK3R2,GRB14,SOS1,NRAS,GRB2,ANGPT4,PIK3CB,KRAS,SHC1,PIK3R1,ANGPT2,HRAS
R-HSA-5635838	Activation of SMO	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	6469,84455,50937,156,23288,132884,11127,2121,3549,409,408,1452,91653,2619,6608,5727,50846	SHH,EFCAB7,CDON,GRK2,IQCE,EVC2,KIF3A,EVC,IHH,ARRB2,ARRB1,CSNK1A1,BOC,GAS1,SMO,PTCH1,DHH
R-HSA-5654710	PI-3K cascade:FGFR3	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	2254,2253,8074,5781,2247,2261,8817,5290,8822,2250,2249,2246,2549,2885,5295,10818,26281	FGF9,FGF8,FGF23,PTPN11,FGF2,FGFR3,FGF18,PIK3CA,FGF17,FGF5,FGF4,FGF1,GAB1,GRB2,PIK3R1,FRS2,FGF20
R-HSA-5654704	SHC-mediated cascade:FGFR3	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	2250,6654,8822,8817,2261,2247,8074,2253,2254,3265,26281,3845,6464,2885,4893,2249,2246	FGF5,SOS1,FGF17,FGF18,FGFR3,FGF2,FGF23,FGF8,FGF9,HRAS,FGF20,KRAS,SHC1,GRB2,NRAS,FGF4,FGF1
R-HSA-209776	Amine-derived hormones	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	7252,389434,6528,7054,7173,1644,5409,1621,15,1733,1734,53905,1735,1081,121278,50506,7166	TSHB,IYD,SLC5A5,TH,TPO,DDC,PNMT,DBH,AANAT,DIO1,DIO2,DUOX1,DIO3,CGA,TPH2,DUOX2,TPH1
R-HSA-5654221	Phospholipase C-mediated cascade; FGFR2	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	2251,2246,2249,2263,2255,27006,26281,2248,2254,2253,8074,2247,5335,8817,8822,2252,2250	FGF6,FGF1,FGF4,FGFR2,FGF10,FGF22,FGF20,FGF3,FGF9,FGF8,FGF23,FGF2,PLCG1,FGF18,FGF17,FGF7,FGF5
R-HSA-1912420	Pre-NOTCH Processing in Golgi	0.338064261611642	-1.08451927845886	18	17	0.00188177994243967	9034	10285	6484,4855,4242,5045,6400,489,10402,487,10959,488,5870,2683,5986,4854,4853,6487,3955	ST3GAL4,NOTCH4,MFNG,FURIN,SEL1L,ATP2A3,ST3GAL6,ATP2A1,TMED2,ATP2A2,RAB6A,B4GALT1,RFNG,NOTCH3,NOTCH2,ST3GAL3,LFNG
R-HSA-1226099	Signaling by FGFR in disease	0.341223411716842	-1.07521784990133	63	57	0.00630949745406243	9034	10285	399687,5290,5430,8817,8822,9530,5335,5433,2254,3845,8805,2885,26127,2249,2252,2963,4686,8074,6776,11064,5295,5431,2264,22916,1523,6777,5432,5439,5440,6772,27006,2255,26281,2260,10818,4893,2263,2251,11052,6774,2250,7750,6654,9846,2962,2261,5434,2253,2247,3265,2248,9208,5441,11160,2549,2246,613	MYO18A,PIK3CA,POLR2A,FGF18,FGF17,BAG4,PLCG1,POLR2D,FGF9,KRAS,TRIM24,GRB2,FGFR1OP2,FGF4,FGF7,GTF2F2,NCBP1,FGF23,STAT5A,CNTRL,PIK3R1,POLR2B,FGFR4,NCBP2,CUX1,STAT5B,POLR2C,POLR2J,POLR2K,STAT1,FGF22,FGF10,FGF20,FGFR1,FRS2,NRAS,FGFR2,FGF6,CPSF6,STAT3,FGF5,ZMYM2,SOS1,GAB2,GTF2F1,FGFR3,POLR2E,FGF8,FGF2,HRAS,FGF3,LRRFIP1,POLR2L,ERLIN2,GAB1,FGF1,BCR
R-HSA-1592230	Mitochondrial biogenesis	0.343975805857469	-1.06718395589182	54	49	0.00542395395173788	9034	10285	8841,9611,506,5565,64784,200186,10891,5465,6742,23054,23373,79718,10499,4208,133522,5600,23410,5563,5571,6604,211,7978,7019,1385,1387,23082,1432,10498,2551,54205,6256,11232,5564,51106,1386,9572,4209,96764,5469,8648,5442,80205,2101,4899,6300,64216,85441,53632,51422	HDAC3,NCOR1,ATP5F1B,PRKAB2,CRTC3,CRTC2,PPARGC1A,PPARA,SSBP1,NCOA6,CRTC1,TBL1XR1,NCOA2,MEF2C,PPARGC1B,MAPK11,SIRT3,PRKAA2,PRKAG1,SMARCD3,ALAS1,MTERF1,TFAM,CREB1,CREBBP,PPRC1,MAPK14,CARM1,GABPA,CYCS,RXRA,POLG2,PRKAB1,TFB1M,ATF2,NR1D1,MEF2D,TGS1,MED1,NCOA1,POLRMT,CHD9,ESRRA,NRF1,MAPK12,TFB2M,HELZ2,PRKAG3,PRKAG2
R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	0.345448859452941	-1.06291066567982	27	25	0.00276732344476422	9034	10285	79728,4361,10111,580,9156,7517,672,83990,10635,5892,5890,7516,5888,641,1763,7156,472,675,10524,116028,80010,5889,51750,4683,7486	PALB2,MRE11,RAD50,BARD1,EXO1,XRCC3,BRCA1,BRIP1,RAD51AP1,RAD51D,RAD51B,XRCC2,RAD51,BLM,DNA2,TOP3A,ATM,BRCA2,KAT5,RMI2,RMI1,RAD51C,RTEL1,NBN,WRN
R-HSA-5654716	Downstream signaling of activated FGFR4	0.345448859452941	-1.06291066567982	27	25	0.00276732344476422	9034	10285	10818,3845,26281,2249,10817,2251,4893,2885,8822,5290,8817,5781,2254,5335,5295,6464,3265,2246,2549,2264,6654,9965,2247,2253,8074	FRS2,KRAS,FGF20,FGF4,FRS3,FGF6,NRAS,GRB2,FGF17,PIK3CA,FGF18,PTPN11,FGF9,PLCG1,PIK3R1,SHC1,HRAS,FGF1,GAB1,FGFR4,SOS1,FGF19,FGF2,FGF8,FGF23
R-HSA-190236	Signaling by FGFR	0.34549378383565	-1.06278062772889	89	80	0.00885543502324552	9034	10285	9965,6233,2250,673,6654,2962,3185,3187,2261,5434,2253,161742,2247,23767,3265,2248,5441,7072,23768,200734,2246,2549,5432,5439,5440,53834,7316,2255,9365,27006,3178,7311,26281,23543,2260,5595,10818,54845,4893,2263,2251,10817,2252,2963,4686,8074,4670,80004,6714,6464,5295,7073,2264,83888,5431,22916,2591,10253,143282,100616459,7314,9982,8817,5430,5290,8822,5515,867,5725,5335,5594,5433,23769,2254,5781,3845,5516,5518,2885,2249	FGF19,RPS27A,FGF5,BRAF,SOS1,GTF2F1,HNRNPF,HNRNPH1,FGFR3,POLR2E,FGF8,SPRED1,FGF2,FLRT3,HRAS,FGF3,POLR2L,TIA1,FLRT2,SPRED2,FGF1,GAB1,POLR2C,POLR2J,POLR2K,FGFRL1,UBC,FGF10,KL,FGF22,HNRNPA1,UBA52,FGF20,RBFOX2,FGFR1,MAPK3,FRS2,ESRP1,NRAS,FGFR2,FGF6,FRS3,FGF7,GTF2F2,NCBP1,FGF23,HNRNPM,ESRP2,SRC,SHC1,PIK3R1,TIAL1,FGFR4,FGFBP2,POLR2B,NCBP2,GALNT3,SPRY2,FGFBP3,MIR4745,UBB,FGFBP1,FGF18,POLR2A,PIK3CA,FGF17,PPP2CA,CBL,PTBP1,PLCG1,MAPK1,POLR2D,FLRT1,FGF9,PTPN11,KRAS,PPP2CB,PPP2R1A,GRB2,FGF4
R-HSA-3000171	Non-integrin membrane-ECM interactions	0.346085066643871	-1.06107067679015	45	41	0.00453841044941333	9034	10285	6383,9378,5155,3918,100422894,6382,87,375790,10319,3914,3685,3688,3915,100616340,3673,3693,100616237,2247,5154,3690,3908,3911,3910,3912,4921,3691,3655,7276,1605,59277,3913,3909,5578,7057,3339,9672,284217,6385,780,7040,3371	SDC2,NRXN1,PDGFB,LAMC2,MIR4260,SDC1,ACTN1,AGRN,LAMC3,LAMB3,ITGAV,ITGB1,LAMC1,MIR4758,ITGA2,ITGB5,MIR4640,FGF2,PDGFA,ITGB3,LAMA2,LAMA5,LAMA4,LAMB1,DDR2,ITGB4,ITGA6,TTR,DAG1,NTN4,LAMB2,LAMA3,PRKCA,THBS1,HSPG2,SDC3,LAMA1,SDC4,DDR1,TGFB1,TNC
R-HSA-176033	Interactions of Vpr with host cellular proteins	0.346991140852012	-1.05845603004704	36	33	0.00365286694708878	9034	10285	79023,8021,9883,291,4927,9818,3836,129401,7175,4928,9631,81929,9688,8815,55706,11097,8086,23511,348995,23279,3159,11168,10762,5903,23165,23636,100101267,55746,57122,53371,9972,23225,79902	NUP37,NUP214,POM121,SLC25A4,NUP88,NUP58,KPNA1,NUP35,TPR,NUP98,NUP155,SEH1L,NUP93,BANF1,NDC1,NUP42,AAAS,NUP188,NUP43,NUP160,HMGA1,PSIP1,NUP50,RANBP2,NUP205,NUP62,POM121C,NUP133,NUP107,NUP54,NUP153,NUP210,NUP85
R-HSA-5357801	Programmed Cell Death	0.347340647429172	-1.05744928770115	175	156	0.0172680982953288	9034	10285	9861,999,1829,5708,5682,8428,5715,5717,7161,7529,7533,3148,5588,5701,836,219699,317,26060,4976,100506658,330,839,7082,7531,353376,3006,122706,8737,3837,7029,596,28988,10197,9491,9414,324,5692,3005,7431,3007,7316,7979,7157,23198,3836,5710,598,143471,54205,3002,1613,5704,23604,4000,10018,5696,841,8655,578,5599,22985,5695,8626,1630,5686,1828,5690,63967,7534,6709,355,27113,23368,10000,148022,5687,4836,5685,2934,693222,79658,5694,6304,140735,7099,5711,5534,5339,8717,56616,1612,5706,4137,3024,329,1830,115209,1869,5718,5707,6233,23643,3146,2810,5366,11035,5684,8772,2620,5700,1677,7311,5699,3008,90427,10059,5713,1676,118,842,5580,1499,5698,3009,356,7159,5062,5720,207,10213,5691,1832,5317,8795,5714,7027,8797,8743,8837,7532,581,10971,840,90249,5693,2339,5747,5533,208,7098,5702,4001,197259,5719,7314,929	PSMD6,CDH1,DSG2,PSMD2,PSMA1,STK24,PSMD9,PSMD11,TP73,YWHAB,YWHAH,HMGB2,PRKCQ,PSMC2,CASP3,UNC5B,APAF1,APPL1,OPA1,OCLN,BIRC3,CASP6,TJP1,YWHAE,TICAM2,H1-2,PSMB11,RIPK1,KPNB1,TFDP2,BCL2,DBNL,PSME3,PSMF1,TJP2,APC,PSMB4,H1-0,VIM,H1-3,UBC,SEM1,TP53,PSME4,KPNA1,PSMD4,BCL2L1,PSMA8,CYCS,GZMB,DAPK3,PSMC4,DAPK2,LMNA,BCL2L11,PSMB8,CASP8,DYNLL1,BAK1,MAPK8,ACIN1,PSMB7,TP63,DCC,PSMA5,DSG1,PSMB2,CLSPN,YWHAZ,SPTAN1,FAS,BBC3,PPP1R13B,AKT3,TICAM1,PSMA6,NMT1,PSMA4,GSN,MIR637,ARHGAP10,PSMB6,SATB1,DYNLL2,TLR4,PSMD5,PPP3R1,PLEC,TRADD,DIABLO,DAPK1,PSMC6,MAPT,H1-1,BIRC2,DSG3,OMA1,E2F1,PSMD12,PSMD1,RPS27A,LY96,HMGB1,SFN,PMAIP1,RIPK3,PSMA3,FADD,GAS2,PSMC1,DFFB,UBA52,PSMB10,H1-4,BMF,DNM1L,PSMD7,DFFA,ADD1,CASP9,PRKCD,CTNNB1,PSMB9,H1-5,FASLG,TP53BP2,PAK2,PSME1,AKT1,PSMD14,PSMB3,DSP,PKP1,TNFRSF10B,PSMD8,TFDP1,TNFRSF10A,TNFSF10,CFLAR,YWHAG,BAX,YWHAQ,CASP7,UNC5A,PSMB5,FNTA,PTK2,PPP3CC,AKT2,TLR3,PSMC3,LMNB1,MLKL,PSMD13,UBB,CD14
R-HSA-5693567	HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)	0.348673596710095	-1.05361904738133	132	118	0.0130617666592871	9034	10285	8339,6117,8343,83990,7517,8360,165918,10111,4361,56655,5893,5427,5888,7516,3364,5985,545,51588,8348,10524,121504,8366,7329,1017,54107,348654,6047,7156,1763,8370,8341,8365,3018,8367,9025,5883,7316,8914,84464,128312,8900,8362,580,7341,23514,8349,7334,5884,890,10714,1111,51548,8344,29086,5982,8359,7486,5889,63967,8290,84126,8970,8363,8340,5111,6233,5981,7336,2072,197342,6118,5890,10635,116028,6613,146956,7158,7311,5983,3017,8368,8346,83695,51750,8361,80010,9577,8347,8345,672,5984,9156,144715,51720,54962,79728,5424,5810,8924,641,9656,2067,84142,151987,25,5531,5892,5429,675,472,51426,8364,11073,57804,7468,4683,6119,7314	H2BC8,RPA1,H2BC7,BRIP1,XRCC3,H4C4,RNF168,RAD50,MRE11,POLE4,RAD52,POLE2,RAD51,XRCC2,HUS1,RFC5,ATR,PIAS4,H2BC17,KAT5,H4C16,H4C2,UBE2I,CDK2,POLE3,GEN1,RNF4,TOP3A,DNA2,H4C14,H2BC15,H4C8,H2BC3,H4C5,RNF8,RAD9A,UBC,TIMELESS,SLX4,H2BC26,CCNA1,H4C12,BARD1,SUMO1,SPIDR,H2BC21,UBE2N,RAD17,CCNA2,POLD3,CHEK1,SIRT6,H2BC6,BABAM1,RFC2,H4C1,WRN,RAD51C,CLSPN,H3-4,ATRIP,H2BC11,H4C11,H2BC13,PCNA,RPS27A,RFC1,UBE2V2,ERCC4,EME2,RPA2,RAD51B,RAD51AP1,RMI2,SUMO2,EME1,TP53BP1,UBA52,RFC3,H2BC5,H4C13,H2BC10,RHNO1,RTEL1,H4C6,RMI1,BABAM2,H2BC4,H2BC9,BRCA1,RFC4,EXO1,RAD9B,UIMC1,TIPIN,PALB2,POLD1,RAD1,HERC2,BLM,MDC1,ERCC1,ABRAXAS1,PPP4R2,ABL1,PPP4C,RAD51D,POLH,BRCA2,ATM,POLK,H4C3,TOPBP1,POLD4,NSD2,NBN,RPA3,UBB
R-HSA-195721	Signaling by Wnt	0.350136244919086	-1.04943292904767	336	298	0.0329864954615895	9034	10285	57680,808,123169,8945,1173,8339,8395,5682,5715,5525,5881,1454,653604,9101,8968,5593,8358,8323,57216,5701,3709,5526,7482,2787,3013,7015,8321,10197,8348,9491,2780,8312,10524,8366,121504,7316,5578,8370,126961,8365,50964,7472,27327,440193,8349,5704,3710,23072,128312,7475,2792,8362,10023,64750,4609,1387,55970,5579,5158,26523,7476,5148,100302237,8454,5530,5686,79971,57690,5690,7534,50999,59345,6422,163,3708,8324,8290,5685,8359,23002,23513,8363,2793,8340,2788,5711,144165,5706,27123,8357,5216,4041,7474,409,79412,6885,7089,6259,3015,9580,5684,805,2033,8325,25776,5699,7311,8361,2791,9978,1175,8347,7484,27121,5713,8350,4343,94239,6423,1499,1452,79577,7471,5698,3065,8452,9559,7088,1455,10213,8658,3012,7976,1857,27161,89780,5714,7483,8322,4221,5592,3021,8364,84870,8313,22943,343637,7481,55737,5702,5516,723790,7473,90780,5515,7091,5331,387,51764,7314,6662,9861,6934,5708,5527,5717,8343,83439,2786,5519,2790,8360,51339,857,8607,83595,4772,59349,1212,8334,122706,5532,55366,26108,324,5692,7979,283149,192669,4040,100126338,6659,23198,8353,5710,143471,8341,3018,8367,1459,2535,160,6500,5330,8295,7090,5696,7477,84133,23112,80351,5879,8354,7480,54331,5695,340419,3020,815,5929,5518,8549,2782,8344,1487,80319,51176,801,10681,5687,81029,51384,5694,5534,51699,64321,8970,8355,5528,5718,5707,4920,23236,6233,3017,8368,2783,8346,9736,57154,5700,4919,8724,6932,59352,192670,9070,607,5880,6597,166,8345,284654,55553,7479,1856,54894,2784,6657,81847,5720,207,1457,161,2932,7855,1213,7478,94235,5691,7514,1855,56998,55766,1211,5693,208,11197,80326,54361,1488,5529,5719,8352,8335,83999,5582,5145	CHD8,CALM3,LEO1,BTRC,AP2M1,H2BC8,PIP5K1B,PSMA1,PSMD9,PPP2R5A,RAC3,CSNK1E,H3C13,USP8,H3C7,PRKG2,H3C2,FZD6,VANGL2,PSMC2,ITPR2,PPP2R5B,WNT2B,GNG5,H2AC7,TERT,FZD1,PSME3,H2BC17,PSMF1,GNAT2,AXIN1,KAT5,H4C2,H4C16,UBC,PRKCA,H4C14,H3C14,H4C8,SOST,WNT2,TNRC6A,CCDC88C,H2BC21,PSMC4,ITPR3,HECW1,H2BC26,WNT6,GNGT1,H4C12,FRAT1,SMURF2,MYC,CREBBP,GNG12,PRKCB,PDE6B,AGO1,WNT7A,PDE6G,MIR1281,CUL1,PPP3CA,PSMA5,WLS,TNRC6C,PSMB2,YWHAZ,TMED5,GNB4,SFRP1,AP2B1,ITPR1,FZD7,H3-4,PSMA4,H4C1,DAAM1,SCRIB,H4C11,GNGT2,H2BC13,GNG7,PSMD5,PRICKLE1,PSMC6,DKK2,H3C10,PFN1,LRP5,WNT5A,ARRB2,KREMEN2,MAP3K7,TLE2,RYK,H2AZ1,SOX13,PSMA3,CALM2,EP300,FZD8,CBY1,PSMB10,UBA52,H4C6,GNG11,RBX1,AP2S1,H2BC4,WNT9B,DKK4,PSMD7,H3C1,MOV10,H2AZ2,SFRP2,CTNNB1,CSNK1A1,CDC73,WNT1,PSMB9,HDAC1,CUL3,VPS26A,TLE1,CSNK1G2,PSMD14,TNKS,H2AC8,FZD3,DVL3,AGO2,WNT3A,PSMD8,WNT9A,FZD4,MEN1,PRKG1,H3-3B,H4C3,RSPO3,AXIN2,DKK1,RSPO4,WNT11,VPS35,PSMC3,PPP2CB,H2AC19,WNT3,PYGO2,PPP2CA,TLE4,PLCB3,RHOA,GNG13,UBB,SOX9,PSMD6,TCF7L2,PSMD2,PPP2R5C,PSMD11,H2BC7,TCF7L1,GNG4,PPP2R1B,GNG10,H4C4,DACT1,CAV1,RUVBL1,SOX7,NFATC1,KLHL12,CLTB,H2AC6,PSMB11,PPP3CB,LGR4,PYGO1,APC,PSMB4,SEM1,BCL9L,AGO3,LRP6,MIR937,SOX4,PSME4,H3C6,PSMD4,PSMA8,H2BC15,H2BC3,H4C5,CSNK2A2,FZD2,AP2A1,SKP1,PLCB2,TRRAP,TLE3,PSMB8,WNT7B,ZNRF3,TNRC6B,TNKS2,RAC1,H3C11,WNT10B,GNG2,PSMB7,RSPO2,H3-3A,CAMK2A,RBBP5,PPP2R1A,LGR5,GNB1,H2BC6,CTBP1,CXXC4,LEF1,CALM1,GNB5,PSMA6,WNT5B,WNT16,PSMB6,PPP3R1,VPS29,SOX17,H2BC11,H3C8,PPP2R5D,PSMD12,PSMD1,ROR2,PLCB1,RPS27A,H2BC5,H4C13,GNB2,H2BC10,USP34,SMURF1,PSMC1,ROR1,SNX3,TCF7,LGR6,AGO4,ASH2L,BCL9,RAC2,SMARCA4,TLE5,H2BC9,RSPO1,SOX6,WNT8B,DVL2,RNF43,GNB3,SOX2,RNF146,PSME1,AKT1,CSNK2A1,AP2A2,GSK3B,FZD5,CLTC,WNT8A,GNG8,PSMB3,XPO1,DVL1,CTNNBIP1,H2AJ,CLTA,PSMB5,AKT2,WIF1,WNT10A,WNT4,CTBP2,PPP2R5E,PSMD13,H3C3,H2AC4,KREMEN1,PRKCG,PDE6A
R-HSA-193634	Axonal growth inhibition (RHOA activation)	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	57142,4099,84894,387,396,4804,4974,9138	RTN4,MAG,LINGO1,RHOA,ARHGDIA,NGFR,OMG,ARHGEF1
R-HSA-1483115	Hydrolysis of LPC	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	5321,123745,283748,100137049,8605,79887,56261,255189	PLA2G4A,PLA2G4E,PLA2G4D,PLA2G4B,PLA2G4C,PLBD1,GPCPD1,PLA2G4F
R-HSA-444473	Formyl peptide receptors bind formyl peptides and many other ligands	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	50865,2358,6288,301,6368,351,2359,2357	HEBP1,FPR2,SAA1,ANXA1,CCL23,APP,FPR3,FPR1
R-HSA-2142789	Ubiquinol biosynthesis	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	57017,84274,27235,51004,51805,23590,10229,57107	COQ9,COQ5,COQ2,COQ6,COQ3,PDSS1,COQ7,PDSS2
R-HSA-110328	Recognition and association of DNA glycosylase with site containing an affected pyrimidine	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	4913,4968,7374,6996,79661,252969,8930,23583	NTHL1,OGG1,UNG,TDG,NEIL1,NEIL2,MBD4,SMUG1
R-HSA-110329	Cleavage of the damaged pyrimidine	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	23583,8930,252969,6996,7374,79661,4968,4913	SMUG1,MBD4,NEIL2,TDG,UNG,NEIL1,OGG1,NTHL1
R-HSA-210747	Regulation of gene expression in early pancreatic precursor cells	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	390874,3651,6928,3175,256297,2494,2255,4825	ONECUT3,PDX1,HNF1B,ONECUT1,PTF1A,NR5A2,FGF10,NKX6-1
R-HSA-1483148	Synthesis of PG	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	5337,122618,114971,9489,8760,5338,23646,201164	PLD1,PLD4,PTPMT1,PGS1,CDS2,PLD2,PLD3,PLD6
R-HSA-73942	DNA Damage Reversal	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	54890,221120,84164,51008,121642,79068,4255,10973	ALKBH5,ALKBH3,ASCC2,ASCC1,ALKBH2,FTO,MGMT,ASCC3
R-HSA-1253288	Downregulation of ERBB4 signaling	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	2066,7316,11059,4734,83737,7314,6233,7311	ERBB4,UBC,WWP1,NEDD4,ITCH,UBB,RPS27A,UBA52
R-HSA-450520	HuR (ELAVL1) binds and stabilizes mRNA	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	8741,5578,8021,7514,5580,6418,1994,8125	TNFSF13,PRKCA,NUP214,XPO1,PRKCD,SET,ELAVL1,ANP32A
R-HSA-73928	Depyrimidination	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	23583,8930,252969,6996,7374,79661,4968,4913	SMUG1,MBD4,NEIL2,TDG,UNG,NEIL1,OGG1,NTHL1
R-HSA-434316	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	23236,2776,5331,2767,2864,2769,5330,9630	PLCB1,GNAQ,PLCB3,GNA11,FFAR1,GNA15,PLCB2,GNA14
R-HSA-5632681	Ligand-receptor interactions	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	50937,64399,3549,6469,50846,5727,2619,91653	CDON,HHIP,IHH,SHH,DHH,PTCH1,GAS1,BOC
R-HSA-2142670	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	1545,1558,1573,2053,1544,1543,1559,1557	CYP1B1,CYP2C8,CYP2J2,EPHX2,CYP1A2,CYP1A1,CYP2C9,CYP2C19
R-HSA-196836	Vitamin C (ascorbate) metabolism	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	9963,6515,1528,9446,1727,9962,6513,119391	SLC23A1,SLC2A3,CYB5A,GSTO1,CYB5R3,SLC23A2,SLC2A1,GSTO2
R-HSA-2408508	Metabolism of ingested SeMet, Sec, MeSec into H2Se	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	51540,875,4143,191,4837,27232,3176,1491	SCLY,CBS,MAT1A,AHCY,NNMT,GNMT,HNMT,CTH
R-HSA-416550	Sema4D mediated inhibition of cell attachment and migration	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	27289,2909,6237,5879,10507,4233,387,5364	RND1,ARHGAP35,RRAS,RAC1,SEMA4D,MET,RHOA,PLXNB1
R-HSA-444821	Relaxin receptors	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	51289,10022,6019,117579,122042,59350,3640,339403	RXFP3,INSL5,RLN2,RLN3,RXFP2,RXFP1,INSL3,RXFP4
R-HSA-400451	Free fatty acids regulate insulin secretion	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	23236,2776,2767,2864,2769,5331,5330,9630	PLCB1,GNAQ,GNA11,FFAR1,GNA15,PLCB3,PLCB2,GNA14
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	0.354195069423272	-1.03790747404855	8	8	0.000885543502324552	9034	10285	9370,5565,51094,79602,6794,5563,51422,51085	ADIPOQ,PRKAB2,ADIPOR1,ADIPOR2,STK11,PRKAA2,PRKAG2,MLXIPL
R-HSA-15869	Metabolism of nucleotides	0.35502270074211	-1.03557354579874	97	87	0.0096302855877795	9034	10285	51727,205,56953,93034,4907,51251,978,271,5198,221264,6240,4830,11164,22978,1635,83549,270,4833,2876,7498,158,953,7083,7378,1716,51733,8833,1633,4831,6241,131870,3615,7371,79077,30833,51292,84618,64902,55270,132,159,25961,2618,2987,79873,204,50484,1854,7084,26289,161823,57089,1806,353,7372,2745,955,471,64077,100,957,847,4860,2766,1807,122481,10606,9615,9583,7296,790,956,3614,122622,7298,1503,203,7295,100500832,53343,151531,4521,3704,5471,272,1723,2936	CMPK1,AK4,NT5M,NT5C1B,NT5E,NT5C3A,CDA,AMPD2,PFAS,AK9,RRM1,NME1,NUDT5,NT5C2,DCTD,UCK1,AMPD1,NME4,GPX1,XDH,ADSL,ENTPD1,TK1,UPP1,DGUOK,UPB1,GMPS,DCK,NME2,RRM2,NUDT16,IMPDH2,UCK2,DCTPP1,NT5C,GMPR2,NT5C1A,AGXT2,NUDT15,ADK,ADSS2,NUDT13,GART,GUK1,NUDT18,AK2,RRM2B,DUT,TK2,AK5,ADAL,ENTPD7,DPYD,APRT,UMPS,GLRX,ENTPD6,ATIC,LHPP,ADA,ENTPD5,CAT,PNP,GMPR,DPYS,AK7,PAICS,GDA,ENTPD4,TXNRD1,CAD,ENTPD3,IMPDH1,ADSS1,TYMS,CTPS1,AK1,TXN,MIR3658,NUDT9,UPP2,NUDT1,ITPA,PPAT,AMPD3,DHODH,GSR
R-HSA-168138	Toll Like Receptor 9 (TLR9) Cascade	0.35502270074211	-1.03557354579874	97	87	0.0096302855877795	9034	10285	1385,4790,7334,5599,6195,64145,1386,6500,5604,6196,6283,23118,5594,148022,57162,1848,466,64127,4214,51295,5518,10454,7867,7189,9261,5609,8454,6288,4792,5601,5289,10392,1849,23291,3665,8945,5970,5608,5519,30849,1147,5598,4205,4615,7316,9252,353376,3551,170506,2353,4793,51135,1326,1432,51231,7314,929,1846,79155,5515,8767,6416,246330,5602,8411,5516,7098,4791,5528,6233,3146,23643,6885,7099,177,7335,5606,3725,57161,3656,54106,351,7311,5600,1660,5595,4208	CREB1,NFKB1,UBE2N,MAPK8,RPS6KA1,RBSN,ATF2,SKP1,MAP2K1,RPS6KA2,S100A12,TAB2,MAPK1,TICAM1,PELI1,DUSP6,ATF1,NOD2,MAP3K1,ECSIT,PPP2R1A,TAB1,MAPKAPK3,TRAF6,MAPKAPK2,MAP2K7,CUL1,SAA1,NFKBIA,MAPK9,PIK3C3,NOD1,DUSP7,FBXW11,IRF7,BTRC,RELA,MAP2K6,PPP2R1B,PIK3R4,CHUK,MAPK7,MEF2A,MYD88,UBC,RPS6KA5,TICAM2,IKBKB,DHX36,FOS,NFKBIB,IRAK4,MAP3K8,MAPK14,VRK3,UBB,CD14,DUSP4,TNIP2,PPP2CA,RIPK2,MAP2K4,PELI3,MAPK10,EEA1,PPP2CB,TLR3,NFKB2,PPP2R5D,RPS27A,HMGB1,LY96,MAP3K7,TLR4,AGER,UBE2V1,MAP2K3,JUN,PELI2,IRAK2,TLR9,APP,UBA52,MAPK11,DHX9,MAPK3,MEF2C
R-HSA-5663202	Diseases of signal transduction	0.355655055332329	-1.03379396355715	369	327	0.036196590657516	9034	10285	55750,8315,55294,7048,1387,4686,1956,1839,4609,4000,6464,5291,2264,10156,5704,6777,22916,51564,9148,7409,5685,3717,399687,5430,5293,10000,5594,9530,5335,930,142678,5170,57085,5690,100302237,8454,5686,2250,9965,388585,5526,6654,5921,50846,2261,9715,10956,2962,9846,8323,6868,5701,2247,79885,2335,253260,145957,7529,23164,1024,83464,5682,5715,5525,56829,11044,11160,55534,9759,5440,892,7316,5159,7276,10197,54845,9491,8087,8312,2263,23462,83933,2069,10827,51107,8322,2963,5296,3066,54567,5714,89780,2309,10213,8658,50852,6714,5295,6017,11140,11064,3932,3065,1026,5698,54518,4193,26508,7314,84441,5515,867,8822,7040,1445,4140,4763,9372,5702,8805,5516,4296,23385,26127,5922,22943,5906,64223,2885,2249,9462,57670,54492,8850,8826,9794,673,79412,118788,409,10142,2248,4041,10718,5706,27123,5947,8546,2266,3815,5950,5711,2549,613,1499,2308,1452,842,153090,2280,5439,9978,10256,27121,5713,100302213,64926,5699,26281,7311,10818,5595,2033,8325,5684,79109,222236,2252,5695,8503,1385,8831,80351,6400,6776,5696,940,10018,1523,6500,5604,5894,55615,5687,9542,8817,5245,1950,7249,5037,4089,9734,5908,1487,3845,22938,6469,3320,5518,9612,3690,7415,7750,11052,283455,5154,3667,8841,685,84335,2064,3084,1147,5717,5527,5519,4088,5708,2246,9861,6934,5710,143471,23493,5432,79718,23198,7979,6772,4040,942,5692,324,2255,2931,9061,122706,4893,611,10533,29851,2475,941,182,3164,7046,8660,1027,5156,7855,2932,2065,8074,5691,207,2244,55109,5720,5431,9444,8437,7414,2066,5155,54894,22906,7450,102,5529,5719,83999,5290,5433,1488,5781,2254,100847012,3674,208,5693,2534,9611,6774,5605,6233,4087,5707,3516,5434,3549,5528,5718,10014,2253,3265,27044,5441,9208,64220,5694,80853,4233,5664,408,3280,23499,27006,9365,2243,5700,4254,84447,6199,2260,3714,3082,2251	AGK,BRAP,FBXW7,TGFBR2,CREBBP,NCBP1,EGFR,HBEGF,MYC,LMNA,SHC1,PIK3CB,FGFR4,RASA4,PSMC4,STAT5B,NCBP2,HDAC7,NEURL1,VAV1,PSMA4,JAK2,MYO18A,POLR2A,PIK3CD,AKT3,MAPK1,BAG4,PLCG1,CD19,MIB2,PDPK1,AGTRAP,PSMB2,MIR1281,CUL1,PSMA5,FGF5,FGF19,HES5,PPP2R5B,SOS1,RASA1,DHH,FGFR3,FAM131B,OS9,GTF2F1,GAB2,FZD6,ADAM17,PSMC2,FGF2,HDAC11,FN1,RICTOR,NRG4,YWHAB,MPRIP,CDK8,APH1B,PSMA1,PSMD9,PPP2R5A,ZC3HAV1,TENT4A,ERLIN2,MAML3,HDAC4,POLR2K,CCNC,UBC,PDGFRB,TTR,PSME3,ESRP1,PSMF1,FXR1,AXIN1,FGFR2,HEY1,HDAC10,EREG,FAM114A2,APH1A,FZD4,GTF2F2,PIK3R2,HDAC2,DLL4,PSMD8,WNT3A,FOXO3,PSMD14,TNKS,TRAT1,SRC,PIK3R1,RLBP1,CDC37,CNTRL,LCK,HDAC1,CDKN1A,PSMB9,APBB1IP,MDM2,HEYL,UBB,MAML2,PPP2CA,CBL,FGF17,TGFB1,CSK,MARK3,NF1,ZFYVE9,PSMC3,TRIM24,PPP2CB,MAP3K11,NCSTN,FGFR1OP2,RASA2,DKK1,RAP1A,MLST8,GRB2,FGF4,RASAL2,KIAA1549,NEURL1B,KAT2B,IQGAP1,MAML1,BRAF,KREMEN2,PIK3AP1,ARRB2,AKAP9,FGF3,LRP5,NRG3,PSMC6,DKK2,RBP1,AP3B1,FGG,KIT,RBP4,PSMD5,GAB1,BCR,CTNNB1,FOXO1,CSNK1A1,CASP9,DAB2IP,FKBP1A,POLR2J,RBX1,CNKSR1,DKK4,PSMD7,MIR1181,RASAL3,PSMB10,FGF20,UBA52,FRS2,MAPK3,EP300,FZD8,PSMA3,MAPKAP1,NAPEPLD,FGF7,PSMB7,PIK3R3,CREB1,SYNGAP1,TNKS2,SEL1L,STAT5A,PSMB8,CD28,BCL2L11,CUX1,SKP1,MAP2K1,RAF1,PRR5,PSMA6,NRG2,FGF18,PHB1,EGF,TSC2,PEBP1,SMAD4,HDAC9,RAP1B,CTBP1,KRAS,SNW1,SHH,HSP90AA1,PPP2R1A,NCOR2,ITGB3,VCP,ZMYM2,CPSF6,KSR2,PDGFA,IRS1,HDAC3,BTC,AKT1S1,ERBB2,NRG1,CHUK,PSMD11,PPP2R5C,PPP2R1B,SMAD3,PSMD2,FGF1,PSMD6,TCF7L2,PSMD4,PSMA8,HEY2,POLR2C,TBL1XR1,PSME4,SEM1,STAT1,LRP6,CD86,PSMB4,APC,FGF10,GSK3A,PAPSS1,PSMB11,NRAS,OPN1SW,ATG7,ICOS,MTOR,CD80,JAG1,NR4A1,TGFBR1,IRS2,CDKN1B,PDGFRA,FZD5,GSK3B,ERBB3,FGF23,PSMB3,AKT1,FGB,AGGF1,PSME1,POLR2B,QKI,RASAL1,VCL,ERBB4,PDGFB,RNF43,TRAK1,VWF,ADAM10,PPP2R5E,PSMD13,KREMEN1,PIK3CA,POLR2D,CTBP2,PTPN11,FGF9,MIR5004,ITGA2B,AKT2,PSMB5,FYN,NCOR1,STAT3,MAP2K2,RPS27A,SMAD2,PSMD1,RBPJ,POLR2E,IHH,PPP2R5D,PSMD12,HDAC5,FGF8,HRAS,SND1,POLR2L,LRRFIP1,STRA6,PSMB6,KDM7A,MET,PSEN2,ARRB1,HES1,MACF1,FGF22,KL,FGA,PSMC1,KITLG,SYVN1,RPS6KB2,FGFR1,JAG2,HGF,FGF6
R-HSA-416482	G alpha (12/13) signalling events	0.359929782499304	-1.02184631516948	88	79	0.00874474208545495	9034	10285	26230,5879,128272,146,94235,27237,84033,54331,388,8503,5296,55970,23263,6655,2784,50650,9639,148,2792,29,100271715,26084,5295,5924,8874,9181,10681,59345,6915,7409,387,51764,389,22899,5290,147,23370,10451,5364,23365,50649,2782,2768,25791,6453,221472,6654,55160,2787,9828,2788,2793,121512,1894,2790,2786,9826,10276,57580,11214,55701,5880,2791,9138,391,57449,7984,8997,9475,2783,389337,998,445328,89846,7204,7410,7074,84904,10672	TIAM2,RAC1,ARHGEF19,ADRA1D,GNG8,ARHGEF16,OBSCN,GNG2,RHOB,PIK3R3,PIK3R2,GNG12,MCF2L,SOS2,GNB3,ARHGEF3,ARHGEF10,ADRA1A,GNGT1,ABR,ARHGEF33,ARHGEF26,PIK3R1,RASGRF2,ARHGEF7,ARHGEF2,GNB5,GNB4,TBXA2R,VAV1,RHOA,GNG13,RHOC,ARHGEF15,PIK3CA,ADRA1B,ARHGEF18,VAV3,PLXNB1,ARHGEF12,ARHGEF4,GNB1,GNA12,NGEF,ITSN1,FGD2,SOS1,ARHGEF10L,GNG5,ARHGEF17,GNG7,GNGT2,FGD4,ECT2,GNG10,GNG4,ARHGEF11,NET1,PREX1,AKAP13,ARHGEF40,RAC2,GNG11,ARHGEF1,RHOG,PLEKHG5,ARHGEF5,KALRN,ROCK2,GNB2,ARHGEF37,CDC42,ARHGEF35,FGD3,TRIO,VAV2,TIAM1,ARHGEF39,GNA13
R-HSA-75153	Apoptotic execution  phase	0.362408281816412	-1.01498385238014	53	48	0.00531326101394731	9034	10285	840,22985,5317,1832,4000,841,5062,3009,2934,63967,4001,6709,1828,5747,2339,3146,100506658,836,329,5588,1830,3148,4137,3024,8428,5339,1829,999,6304,1499,5580,118,1676,10059,3836,7431,3005,3007,324,3008,2620,28988,9414,1677,3837,839,3006,7082	CASP7,ACIN1,PKP1,DSP,LMNA,CASP8,PAK2,H1-5,GSN,CLSPN,LMNB1,SPTAN1,DSG1,PTK2,FNTA,HMGB1,OCLN,CASP3,BIRC2,PRKCQ,DSG3,HMGB2,MAPT,H1-1,STK24,PLEC,DSG2,CDH1,SATB1,CTNNB1,PRKCD,ADD1,DFFA,DNM1L,KPNA1,VIM,H1-0,H1-3,APC,H1-4,GAS2,DBNL,TJP2,DFFB,KPNB1,CASP6,H1-2,TJP1
R-HSA-6806667	Metabolism of fat-soluble vitamins	0.362408281816412	-1.01498385238014	53	48	0.00531326101394731	9034	10285	7804,4035,6382,348,10082,8029,337,344,4036,335,2638,154807,1591,5641,336,2262,5406,55937,345,1208,53630,26020,338,9227,338328,57016,3339,29914,5947,375790,3949,6383,1109,5950,1594,151056,79001,5948,1645,2817,7276,51109,4023,29967,120227,6385,9672,8644	LRP8,LRP1,SDC1,APOE,GPC6,CUBN,APOA4,APOC2,LRP2,APOA1,GC,VKORC1L1,CYP24A1,LGMN,APOA2,GPC5,PNLIP,APOM,APOC3,CLPS,BCO1,LRP10,APOB,LRAT,GPIHBP1,AKR1B10,HSPG2,UBIAD1,RBP1,AGRN,LDLR,SDC2,AKR1C4,RBP4,CYP27B1,PLB1,VKORC1,RBP2,AKR1C1,GPC1,TTR,RDH11,LPL,LRP12,CYP2R1,SDC4,SDC3,AKR1C3
R-HSA-196849	Metabolism of water-soluble vitamins and cofactors	0.365885182557093	-1.00543570365809	122	109	0.012065530219172	9034	10285	5646,10135,2194,6515,2694,128240,79178,5168,4524,8884,6472,5740,4338,440387,80025,83594,53354,54956,64802,23057,4907,79717,4548,60496,80308,113278,55312,686,9963,55191,32,54,9390,119391,160428,5096,6947,65220,80704,6470,143,60386,25902,54625,81693,10243,27010,5095,5169,51293,27231,54981,160728,166785,5167,84875,55034,55229,10797,55163,10840,1528,4552,683,4837,326625,9962,27304,2350,5743,8029,6513,55788,1504,27249,56922,4522,4594,4337,79646,83666,4363,349565,23475,8876,441024,952,5644,200895,8034,60490,56965,8875,316,31,55065,10560,55739,5826,10588,81034,8566,3141,11330,9446,1582,1727,5091,1719	PRSS3,NAMPT,FASN,SLC2A3,CBLIF,NAXE,THTPA,ENPP2,MTHFR,SLC5A6,SHMT2,PTGIS,MOCS2,CTRB2,PANK2,NUDT12,PANK1,PARP16,NMNAT1,NMNAT2,NT5E,PPCS,MTR,AASDHPPT,FLAD1,SLC52A3,RFK,BTD,SLC23A1,NADSYN1,ACACB,ACP5,SLC22A13,GSTO2,ALDH1L2,PCCB,TCN1,NADK,SLC19A3,SHMT1,PARP4,SLC25A19,MTHFD1L,PARP14,AMN,GPHN,TPK1,PCCA,ENPP3,CD320,NMRK2,NMRK1,SLC5A8,MMAA,ENPP1,PARP10,MOCOS,PANK4,MTHFD2,PNPO,ALDH1L1,CYB5A,MTRR,BST1,NNMT,MMAB,SLC23A2,MOCS3,FOLR2,PTGS2,CUBN,SLC2A1,LMBRD1,CTRB1,MMADHC,MCCC1,MTHFD1,MMUT,MOCS1,PANK3,PARP9,ABCC1,NMNAT3,QPRT,VNN1,MTHFD2L,CD38,PRSS1,DHFR2,SLC25A16,PPCDC,PARP6,VNN2,AOX1,ACACA,SLC52A1,SLC19A2,NAXD,ABCD4,MTHFS,SLC25A32,PDXK,HLCS,CTRC,GSTO1,CYP8B1,CYB5R3,PC,DHFR
R-HSA-109606	Intrinsic Pathway for Apoptosis	0.366309490754385	-1.00427669974764	44	40	0.00442771751162276	9034	10285	3002,140735,54205,56616,5534,7159,207,841,7161,10018,7529,8655,7533,7027,1869,578,836,5599,317,840,581,7532,10971,7531,8626,2810,5366,7029,5533,596,208,90427,7534,23368,10000,7157,27113,598,4836,842	GZMB,DYNLL2,CYCS,DIABLO,PPP3R1,TP53BP2,AKT1,CASP8,TP73,BCL2L11,YWHAB,DYNLL1,YWHAH,TFDP1,E2F1,BAK1,CASP3,MAPK8,APAF1,CASP7,BAX,YWHAG,YWHAQ,YWHAE,TP63,SFN,PMAIP1,TFDP2,PPP3CC,BCL2,AKT2,BMF,YWHAZ,PPP1R13B,AKT3,TP53,BBC3,BCL2L1,NMT1,CASP9
R-HSA-4791275	Signaling by WNT in cancer	0.369607516500684	-0.995313602568899	35	32	0.00354217400929821	9034	10285	22943,5518,324,5516,8312,1487,8325,1488,27121,4040,1499,1452,5515,5529,83999,6934,54894,4041,8658,5527,27123,5519,5525,5528,89780,8323,80351,7855,2932,8322,5526,79412	DKK1,PPP2R1A,APC,PPP2CB,AXIN1,CTBP1,FZD8,CTBP2,DKK4,LRP6,CTNNB1,CSNK1A1,PPP2CA,PPP2R5E,KREMEN1,TCF7L2,RNF43,LRP5,TNKS,PPP2R5C,DKK2,PPP2R1B,PPP2R5A,PPP2R5D,WNT3A,FZD6,TNKS2,FZD5,GSK3B,FZD4,PPP2R5B,KREMEN2
R-HSA-2142845	Hyaluronan metabolism	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	6548,3036,3038,57214,8372,8692,3037,2990,10894,3074,11261,3161,3373,960,10057,55576	SLC9A1,HAS1,HAS3,CEMIP,HYAL3,HYAL2,HAS2,GUSB,LYVE1,HEXB,CHP1,HMMR,HYAL1,CD44,ABCC5,STAB2
R-HSA-2033519	Activated point mutants of FGFR2	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	2255,27006,26281,2248,2251,2246,2249,2263,8817,8822,2252,2250,2253,2254,8074,2247	FGF10,FGF22,FGF20,FGF3,FGF6,FGF1,FGF4,FGFR2,FGF18,FGF17,FGF7,FGF5,FGF8,FGF9,FGF23,FGF2
R-HSA-140534	Ligand-dependent caspase activation	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	353376,8717,8772,8737,7099,356,7098,841,355,8743,148022,8797,8795,8837,23643,929	TICAM2,TRADD,FADD,RIPK1,TLR4,FASLG,TLR3,CASP8,FAS,TNFSF10,TICAM1,TNFRSF10A,TNFRSF10B,CFLAR,LY96,CD14
R-HSA-1482922	Acyl chain remodelling of PI	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	22925,255189,64600,5320,5322,30814,8605,11145,79143,26279,123745,79887,5319,283748,81579,5321	PLA2R1,PLA2G4F,PLA2G2F,PLA2G2A,PLA2G5,PLA2G2E,PLA2G4C,PLAAT3,MBOAT7,PLA2G2D,PLA2G4E,PLBD1,PLA2G1B,PLA2G4D,PLA2G12A,PLA2G4A
R-HSA-156711	Polo-like kinase mediated events	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	1063,5347,7465,55957,9133,993,91750,2033,5928,100302237,286826,9088,132660,4605,891,995	CENPF,PLK1,WEE1,LIN37,CCNB2,CDC25A,LIN52,EP300,RBBP4,MIR1281,LIN9,PKMYT1,LIN54,MYBL2,CCNB1,CDC25C
R-HSA-442729	CREB phosphorylation through the activation of CaMKII	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	815,817,805,818,808,1742,2906,2903,2904,801,88,1385,2905,10142,816,4747	CAMK2A,CAMK2D,CALM2,CAMK2G,CALM3,DLG4,GRIN2D,GRIN2A,GRIN2B,CALM1,ACTN2,CREB1,GRIN2C,AKAP9,CAMK2B,NEFL
R-HSA-192456	Digestion of dietary lipid	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	200879,1056,5408,340654,1208,9388,149998,8513,64788,5406,119548,142910,3990,643418,643414,5407	LIPH,CEL,PNLIPRP2,LIPM,CLPS,LIPG,LIPI,LIPF,LMF1,PNLIP,PNLIPRP3,LIPJ,LIPC,LIPN,LIPK,PNLIPRP1
R-HSA-5627117	RHO GTPases Activate ROCKs	0.369666106684096	-0.995155095132148	17	16	0.0017710870046491	9034	10285	3985,10398,4627,4660,9475,79784,4659,4637,4629,5500,388,3984,103910,389,387,4628	LIMK2,MYL9,MYH9,PPP1R12B,ROCK2,MYH14,PPP1R12A,MYL6,MYH11,PPP1CB,RHOB,LIMK1,MYL12B,RHOC,RHOA,MYH10
R-HSA-1474165	Reproduction	0.37149680729499	-0.9902150089528	26	24	0.00265663050697365	9034	10285	11085,5016,6677,117155,284359,57829,7784,928,347732,257062,2515,2683,79820,117144,126123,8747,113177,157855,8748,7783,84329,378807,57828,100129669	ADAM30,OVGP1,SPAM1,CATSPER2,IZUMO1,ZP4,ZP3,CD9,CATSPER3,CATSPERD,ADAM2,B4GALT1,CATSPERB,CATSPER1,IZUMO2,ADAM21,IZUMO4,KCNU1,ADAM20,ZP2,HVCN1,CATSPER4,CATSPERG,IZUMO3
R-HSA-73848	Pyrimidine metabolism	0.37149680729499	-0.9902150089528	26	24	0.00265663050697365	9034	10285	7372,1806,7084,1854,978,51251,4907,56953,83549,1807,1635,1633,7298,7378,7083,51733,790,1723,30833,151531,7371,100500832,64902,84618	UMPS,DPYD,TK2,DUT,CDA,NT5C3A,NT5E,NT5M,UCK1,DPYS,DCTD,DCK,TYMS,UPP1,TK1,UPB1,CAD,DHODH,NT5C,UPP2,UCK2,MIR3658,AGXT2,NT5C1A
R-HSA-1187000	Fertilization	0.37149680729499	-0.9902150089528	26	24	0.00265663050697365	9034	10285	113177,8747,126123,79820,117144,2683,100129669,378807,57828,7783,8748,84329,157855,57829,117155,284359,6677,5016,11085,2515,347732,257062,928,7784	IZUMO4,ADAM21,IZUMO2,CATSPERB,CATSPER1,B4GALT1,IZUMO3,CATSPER4,CATSPERG,ZP2,ADAM20,HVCN1,KCNU1,ZP4,CATSPER2,IZUMO1,SPAM1,OVGP1,ADAM30,ADAM2,CATSPER3,CATSPERD,CD9,ZP3
R-HSA-210991	Basigin interactions	0.37149680729499	-0.9902150089528	26	24	0.00265663050697365	9034	10285	5478,6520,481,23759,3655,3675,23657,682,56301,11136,6693,9123,8140,483,9056,4099,857,3688,6566,482,9057,23539,4312,23428	PPIA,SLC3A2,ATP1B1,PPIL2,ITGA6,ITGA3,SLC7A11,BSG,SLC7A10,SLC7A9,SPN,SLC16A3,SLC7A5,ATP1B3,SLC7A7,MAG,CAV1,ITGB1,SLC16A1,ATP1B2,SLC7A6,SLC16A8,MMP1,SLC7A8
R-HSA-109581	Apoptosis	0.378946207151368	-0.970361017610795	172	153	0.0169360194819571	9034	10285	5747,5533,2339,90249,5693,5702,208,7098,4001,929,7314,5719,5062,356,7159,5698,3009,207,10213,5720,7027,8797,8743,5317,8795,5714,1832,5691,840,581,7532,10971,8837,8772,5684,2810,5366,3008,5699,90427,7311,5700,1677,2620,10059,5713,5580,1499,842,118,1676,8717,5339,56616,7099,5534,5711,6304,140735,693222,5694,79658,3024,4137,5706,1612,5718,1869,115209,1830,329,3146,23643,6233,5707,8626,1828,5690,1630,5686,23368,10000,148022,27113,6709,355,7534,63967,2934,5685,5687,4836,1613,5704,3002,54205,841,5696,4000,10018,23604,578,8655,5695,22985,5599,7029,3837,8737,122706,7531,7082,353376,3006,839,324,5692,10197,9491,9414,28988,596,3836,7157,23198,7979,3007,7316,3005,7431,5710,143471,598,5708,999,1829,9861,7161,7529,5717,5682,5715,8428,219699,5701,836,3148,7533,5588,26060,4976,100506658,317	PTK2,PPP3CC,FNTA,UNC5A,PSMB5,PSMC3,AKT2,TLR3,LMNB1,CD14,UBB,PSMD13,PAK2,FASLG,TP53BP2,PSMB9,H1-5,AKT1,PSMD14,PSME1,TFDP1,TNFRSF10A,TNFSF10,PKP1,TNFRSF10B,PSMD8,DSP,PSMB3,CASP7,BAX,YWHAG,YWHAQ,CFLAR,FADD,PSMA3,SFN,PMAIP1,H1-4,PSMB10,BMF,UBA52,PSMC1,DFFB,GAS2,DNM1L,PSMD7,PRKCD,CTNNB1,CASP9,ADD1,DFFA,TRADD,PLEC,DIABLO,TLR4,PPP3R1,PSMD5,SATB1,DYNLL2,MIR637,PSMB6,ARHGAP10,H1-1,MAPT,PSMC6,DAPK1,PSMD12,E2F1,OMA1,DSG3,BIRC2,HMGB1,LY96,RPS27A,PSMD1,TP63,DSG1,PSMB2,DCC,PSMA5,PPP1R13B,AKT3,TICAM1,BBC3,SPTAN1,FAS,YWHAZ,CLSPN,GSN,PSMA4,PSMA6,NMT1,DAPK3,PSMC4,GZMB,CYCS,CASP8,PSMB8,LMNA,BCL2L11,DAPK2,BAK1,DYNLL1,PSMB7,ACIN1,MAPK8,TFDP2,KPNB1,RIPK1,PSMB11,YWHAE,TJP1,TICAM2,H1-2,CASP6,APC,PSMB4,PSME3,PSMF1,TJP2,DBNL,BCL2,KPNA1,TP53,PSME4,SEM1,H1-3,UBC,H1-0,VIM,PSMD4,PSMA8,BCL2L1,PSMD2,CDH1,DSG2,PSMD6,TP73,YWHAB,PSMD11,PSMA1,PSMD9,STK24,UNC5B,PSMC2,CASP3,HMGB2,YWHAH,PRKCQ,APPL1,OPA1,OCLN,APAF1
R-HSA-168188	Toll Like Receptor TLR6:TLR2 Cascade	0.383281941133992	-0.958984421887658	95	85	0.00940889971219836	9034	10285	79155,4214,5515,51295,466,7314,929,64127,1846,57162,1848,7097,51231,5594,5516,4791,8454,6288,9261,5609,5602,7189,6416,8767,246330,5518,7096,10454,7867,5599,4793,6195,2353,7334,8651,3551,1385,4790,114609,6196,6283,23118,1432,5604,6500,1326,51135,1386,3656,57161,7316,4615,5598,4205,5595,948,4208,7311,5600,1660,10333,351,9252,23291,6885,6233,3146,23643,10392,1849,5601,4792,5528,5519,59307,3725,1147,11213,5606,7335,5608,7099,8945,5970,177	TNIP2,MAP3K1,PPP2CA,ECSIT,ATF1,UBB,CD14,NOD2,DUSP4,PELI1,DUSP6,TLR2,VRK3,MAPK1,PPP2CB,NFKB2,CUL1,SAA1,MAPKAPK2,MAP2K7,MAPK10,TRAF6,MAP2K4,RIPK2,PELI3,PPP2R1A,TLR1,TAB1,MAPKAPK3,MAPK8,NFKBIB,RPS6KA1,FOS,UBE2N,SOCS1,IKBKB,CREB1,NFKB1,TIRAP,RPS6KA2,S100A12,TAB2,MAPK14,MAP2K1,SKP1,MAP3K8,IRAK4,ATF2,IRAK2,PELI2,UBC,MYD88,MAPK7,MEF2A,MAPK3,CD36,MEF2C,UBA52,MAPK11,DHX9,TLR6,APP,RPS6KA5,FBXW11,MAP3K7,RPS27A,HMGB1,LY96,NOD1,DUSP7,MAPK9,NFKBIA,PPP2R5D,PPP2R1B,SIGIRR,JUN,CHUK,IRAK3,MAP2K3,UBE2V1,MAP2K6,TLR4,BTRC,RELA,AGER
R-HSA-166058	MyD88:Mal cascade initiated on plasma membrane	0.383281941133992	-0.958984421887658	95	85	0.00940889971219836	9034	10285	5598,4205,7316,4615,57161,3656,9252,351,5600,1660,10333,7311,948,5595,4208,5528,4792,5601,3146,23643,1849,10392,6233,23291,6885,177,8945,7099,5970,7335,5608,5606,11213,59307,3725,1147,5519,5594,51231,7097,1848,57162,929,1846,64127,466,7314,5515,51295,79155,4214,10454,7867,5518,7096,6416,8767,246330,7189,5609,5602,9261,4791,8454,6288,5516,3551,1385,4790,8651,7334,2353,4793,6195,5599,51135,1386,1326,5604,6500,1432,23118,6196,114609,6283	MAPK7,MEF2A,UBC,MYD88,PELI2,IRAK2,RPS6KA5,APP,MAPK11,DHX9,TLR6,UBA52,CD36,MAPK3,MEF2C,PPP2R5D,NFKBIA,MAPK9,HMGB1,LY96,DUSP7,NOD1,RPS27A,FBXW11,MAP3K7,AGER,BTRC,TLR4,RELA,UBE2V1,MAP2K6,MAP2K3,IRAK3,SIGIRR,JUN,CHUK,PPP2R1B,MAPK1,VRK3,TLR2,DUSP6,PELI1,CD14,DUSP4,NOD2,ATF1,UBB,PPP2CA,ECSIT,TNIP2,MAP3K1,TAB1,MAPKAPK3,PPP2R1A,TLR1,MAP2K4,RIPK2,PELI3,TRAF6,MAP2K7,MAPK10,MAPKAPK2,NFKB2,CUL1,SAA1,PPP2CB,IKBKB,CREB1,NFKB1,SOCS1,UBE2N,FOS,NFKBIB,RPS6KA1,MAPK8,IRAK4,ATF2,MAP3K8,MAP2K1,SKP1,MAPK14,TAB2,RPS6KA2,TIRAP,S100A12
R-HSA-168179	Toll Like Receptor TLR1:TLR2 Cascade	0.383281941133992	-0.958984421887658	95	85	0.00940889971219836	9034	10285	4790,3551,1385,2353,7334,8651,5599,6195,4793,1386,51135,6500,5604,1326,1432,6283,114609,6196,23118,7097,5594,51231,57162,1848,7314,466,64127,1846,929,4214,79155,5515,51295,7096,5518,7867,10454,7189,246330,8767,6416,9261,5602,5609,5516,6288,8454,4791,4792,5528,5601,6233,3146,23643,1849,10392,6885,23291,5970,7099,8945,177,5608,7335,11213,5606,5519,1147,59307,3725,4205,5598,57161,7316,4615,3656,9252,351,7311,1660,10333,5600,4208,948,5595	NFKB1,IKBKB,CREB1,FOS,UBE2N,SOCS1,MAPK8,RPS6KA1,NFKBIB,ATF2,IRAK4,SKP1,MAP2K1,MAP3K8,MAPK14,S100A12,TIRAP,RPS6KA2,TAB2,TLR2,MAPK1,VRK3,PELI1,DUSP6,UBB,ATF1,NOD2,DUSP4,CD14,MAP3K1,TNIP2,PPP2CA,ECSIT,TLR1,PPP2R1A,MAPKAPK3,TAB1,TRAF6,PELI3,RIPK2,MAP2K4,MAPKAPK2,MAPK10,MAP2K7,PPP2CB,SAA1,CUL1,NFKB2,NFKBIA,PPP2R5D,MAPK9,RPS27A,HMGB1,LY96,DUSP7,NOD1,MAP3K7,FBXW11,RELA,TLR4,BTRC,AGER,MAP2K6,UBE2V1,IRAK3,MAP2K3,PPP2R1B,CHUK,SIGIRR,JUN,MEF2A,MAPK7,PELI2,UBC,MYD88,IRAK2,RPS6KA5,APP,UBA52,DHX9,TLR6,MAPK11,MEF2C,CD36,MAPK3
R-HSA-181438	Toll Like Receptor 2 (TLR2) Cascade	0.383281941133992	-0.958984421887658	95	85	0.00940889971219836	9034	10285	5608,7335,5970,7099,8945,177,5519,1147,3725,59307,11213,5606,5601,4792,5528,6885,23291,6233,3146,23643,10392,1849,351,9252,4208,948,5595,7311,10333,1660,5600,57161,7316,4615,4205,5598,3656,6500,5604,1326,1386,51135,6283,6196,114609,23118,1432,4790,3551,1385,5599,6195,4793,2353,8651,7334,7189,246330,6416,8767,5518,7096,7867,10454,5516,6288,4791,8454,9261,5602,5609,57162,1848,7097,5594,51231,4214,79155,51295,5515,7314,466,64127,1846,929	MAP2K6,UBE2V1,RELA,TLR4,BTRC,AGER,PPP2R1B,CHUK,JUN,SIGIRR,IRAK3,MAP2K3,MAPK9,NFKBIA,PPP2R5D,MAP3K7,FBXW11,RPS27A,HMGB1,LY96,NOD1,DUSP7,APP,RPS6KA5,MEF2C,CD36,MAPK3,UBA52,TLR6,DHX9,MAPK11,PELI2,UBC,MYD88,MEF2A,MAPK7,IRAK2,SKP1,MAP2K1,MAP3K8,ATF2,IRAK4,S100A12,RPS6KA2,TIRAP,TAB2,MAPK14,NFKB1,IKBKB,CREB1,MAPK8,RPS6KA1,NFKBIB,FOS,SOCS1,UBE2N,TRAF6,PELI3,MAP2K4,RIPK2,PPP2R1A,TLR1,MAPKAPK3,TAB1,PPP2CB,SAA1,NFKB2,CUL1,MAPKAPK2,MAPK10,MAP2K7,PELI1,DUSP6,TLR2,MAPK1,VRK3,MAP3K1,TNIP2,ECSIT,PPP2CA,UBB,ATF1,NOD2,DUSP4,CD14
R-HSA-5696395	Formation of Incision Complex in GG-NER	0.387242163183494	-0.94870503698872	43	39	0.00431702457383219	9034	10285	7314,10038,8451,8554,2968,6119,9978,9557,7316,7311,1643,404672,6613,2071,6612,2965,1642,1022,2967,7329,7507,7334,6233,2073,902,2072,6118,2067,5886,7336,54778,2068,6117,4331,142,5887,7508,85015,7341	UBB,PARP2,CUL4A,PIAS1,GTF2H4,RPA3,RBX1,CHD1L,UBC,UBA52,DDB2,GTF2H5,SUMO2,ERCC3,SUMO3,GTF2H1,DDB1,CDK7,GTF2H3,UBE2I,XPA,UBE2N,RPS27A,ERCC5,CCNH,ERCC4,RPA2,ERCC1,RAD23A,UBE2V2,RNF111,ERCC2,RPA1,MNAT1,PARP1,RAD23B,XPC,USP45,SUMO1
R-HSA-983169	Class I MHC mediated antigen processing & presentation	0.388105864248947	-0.946477130572123	373	330	0.0365286694708878	9034	10285	118424,255488,3693,55175,899,89890,55070,9902,5711,9730,51465,7337,6890,51444,23304,9867,154214,26234,5706,5713,811,9978,6737,150726,4360,5684,7322,26091,6477,7311,1535,10616,5699,154881,54926,25793,9341,84861,948,5714,3551,55236,10425,64320,3136,7325,868,6810,122769,8452,89910,9354,7326,84541,3135,5698,57674,144699,142686,9632,10213,1520,53339,27252,5930,3107,55905,26272,26268,7314,51619,4008,22872,10393,29116,51434,5702,9817,5701,140460,142685,3134,10952,4591,23291,140459,8945,100616150,51666,283807,6921,6502,285231,401036,997,23014,5071,11065,92591,7324,5715,5682,9320,10802,8453,9871,91694,6923,23480,51320,92912,7316,821,6478,114088,8065,140739,55284,55008,9820,9491,10197,10489,9903,55294,64750,114907,7321,64718,79654,57520,10324,5704,90025,10427,26224,202658,3093,26235,140458,83737,201456,26267,84937,142678,9690,84708,7428,146330,222235,3133,197131,23352,5685,7096,84676,64410,5690,54850,7323,5686,51088,7174,8773,8454,5718,131405,140461,23608,7336,4012,6233,2209,23327,23643,9039,79791,5707,26259,55176,7099,79876,5694,84231,7335,84078,6396,84961,200845,9870,93611,90933,4689,9021,10293,51529,7704,7318,127247,148581,57154,50489,136371,10333,100847079,65264,5700,51433,6049,5691,7327,1514,8697,90678,29927,55585,63893,10533,55958,8651,23295,4688,3309,8924,221687,2210,57531,6892,80196,54778,8139,5720,126433,114609,80028,7332,55521,89122,3105,25831,929,51343,8916,10484,5719,29945,25897,7320,5693,63891,3106,23194,9554,55658,51128,51676,143279,26263,64167,8925,5708,9616,55819,9861,84085,22954,51665,54620,1515,55182,6468,1147,5717,3685,390594,23198,92369,10477,996,6891,4615,7979,80176,143471,653361,5710,140691,122706,6047,9520,127544,57630,5692,84261,51752,642,991,5695,9604,223082,51130,7334,26046,26249,10273,6500,10193,7328,26232,5696,4734,51191,7097,567,11059,23376,26223,11275,5687,9246,9666,115290,64682,22888,79754,57542,8673,25898,26270,26190	UBE2J2,RNF144B,ITGB5,KLHL11,CCNF,KBTBD6,DET1,MRC2,PSMD5,DCAF1,UBE2J1,UBE3A,TAP1,RNF138,UBR2,PJA2,RNF217,FBXL5,PSMC6,PSMD7,CALR,RBX1,TRIM21,FBXO41,MRC1,PSMA3,UBE2D2,HERC4,SIAH1,UBA52,CYBA,RBCK1,PSMB10,KCTD7,UBE2R2,FBXO7,VAMP3,KLHL22,CD36,PSMD8,IKBKB,UBA6,ARIH2,RNF25,HLA-H,UBE2E2,CBLB,STX4,LRR1,CUL3,UBE3B,UBE4A,UBE2G1,KBTBD8,HLA-G,PSMB9,RNF213,FBXL14,ASB14,SEC24C,PSMD14,CTSS,BTBD1,KLHL20,RBBP6,HLA-C,RNF114,FBXO4,FBXO9,UBB,UBE2D4,LMO7,SEC31A,ANAPC10,MYLIP,ANAPC7,PSMC3,KEAP1,PSMC2,ASB7,ASB15,HLA-F,SEC61B,TRIM37,FBXW11,ASB6,BTRC,MIR4720,ASB4,FBXL22,ELOC,SKP2,FBXW12,ASB18,CDC34,FBXO21,PRKN,UBE2C,ASB16,UBE2E1,PSMD9,PSMA1,TRIP12,SEC24A,CUL2,SEC24D,LONRF1,ELOB,SEC61G,MEX3C,UBE2Q2,UBC,CANX,SIAH2,TRIM9,CUL5,UBE2F,UBE2W,HERC6,CUL7,PSMF1,PSME3,LRRC41,KLHL21,FBXW7,SMURF2,FBXO32,UBE2D1,UNKL,HECTD3,HECW2,KLHL41,PSMC4,UBE3D,SEC24B,FBXL3,TRIM39-RPP21,UBE2K,FBXL4,ASB5,ITCH,FBXO15,FBXO10,ZNRF1,MIB2,UBE3C,LNX1,VHL,FBXL16,FBXL13,HLA-E,UBR1,UBR4,PSMA4,TLR1,TRIM63,KLHL25,PSMB2,FBXL12,UBE2D3,PSMA5,KLHL5,TPP2,SNAP23,CUL1,PSMD12,TRIM71,ASB8,MKRN1,UBE2V2,LNPEP,RPS27A,FCGR1A,NEDD4L,LY96,UBA3,FBXO31,PSMD1,FBXW8,SEC61A2,TLR4,UBA5,PSMB6,TRAF7,UBE2V1,KBTBD7,SEC13,FBXL20,KCTD6,AREL1,FBXO44,TRIM41,NCF4,SOCS3,TRAIP,ANAPC11,ZBTB16,UBA7,ASB17,UBE2U,SMURF1,CD207,ASB10,TLR6,MIR5193,UBE2Z,PSMC1,ANAPC5,RNF6,PSMB3,UBE2G2,CTSL,CDC23,LRSAM1,SEC61A1,UBE2Q1,UBE2O,ATG7,KLHL9,SOCS1,MGRN1,NCF2,HSPA5,HERC2,RNF182,FCGR1BP,HACE1,TAPBP,RNF34,RNF111,GAN,PSME1,FBXO27,TIRAP,FBXL18,UBE2L3,TRIM36,TRIM4,HLA-A,HECTD1,CD14,FZR1,HERC3,SEC23A,PSMD13,ANAPC4,RNF19A,UBE2B,PSMB5,RNF123,HLA-B,FBXL7,SEC22B,RNF126,SAR1B,ASB2,HECTD2,FBXO22,ERAP2,HERC1,PSMD2,RNF7,RNF130,PSMD6,FBXO30,TRIM32,ASB1,FBXL19,CTSV,RNF220,FBXW4,CHUK,PSMD11,ITGAV,KBTBD13,PSME4,SPSB4,UBE2E3,CDC27,TAP2,MYD88,SEM1,SPSB1,PSMA8,NCF1,PSMD4,TRIM69,PSMB11,RNF4,NPEPPS,RNF19B,SH3RF1,PSMB4,FBXW9,ERAP1,BLMH,CDC20,PSMB7,RNF14,ZNRF2,ASB3,UBE2N,LTN1,KLHL3,STUB1,SKP1,RNF41,UBE2H,FBXO2,PSMB8,NEDD4,HERC5,TLR2,B2M,WWP1,UFL1,FBXL21P,KLHL2,PSMA6,UBE2L6,DZIP3,FBXO17,ANAPC1,UBOX5,ASB13,KLHL42,VAMP8,RCHY1,FBXO6,FBXW2
R-HSA-5632684	Hedgehog 'on' state	0.389746952033088	-0.942257591387626	86	77	0.00852335620987381	9034	10285	8405,5687,5727,5685,5719,7314,91653,8650,5693,84455,6469,5686,11127,5702,5690,25989,64750,5691,5714,5695,2736,374654,156,339745,50937,5698,5704,51684,8452,5720,83737,2737,10213,2735,5696,408,7979,7316,5713,23198,9978,143471,5710,79577,1452,64399,57154,122706,5684,9491,23288,10197,5700,7311,5692,5699,409,5701,5718,3549,50846,5707,6608,2619,6233,22873,5694,9861,5711,5708,5715,132884,5682,2121,5717,23432,5706	SPOP,PSMA6,PTCH1,PSMA4,PSMD13,UBB,BOC,NUMB,PSMB5,EFCAB7,SHH,PSMA5,KIF3A,PSMC3,PSMB2,ULK3,SMURF2,PSMB3,PSMD8,PSMB7,GLI2,KIF7,GRK2,SPOPL,CDON,PSMB9,PSMC4,SUFU,CUL3,PSME1,ITCH,GLI3,PSMD14,GLI1,PSMB8,ARRB1,SEM1,UBC,PSMD7,PSME4,RBX1,PSMA8,PSMD4,CDC73,CSNK1A1,HHIP,SMURF1,PSMB11,PSMA3,PSMF1,IQCE,PSME3,PSMC1,UBA52,PSMB4,PSMB10,ARRB2,PSMC2,PSMD12,IHH,DHH,PSMD1,SMO,GAS1,RPS27A,DZIP1,PSMB6,PSMD6,PSMD5,PSMD2,PSMD9,EVC2,PSMA1,EVC,PSMD11,GPR161,PSMC6
R-HSA-3928663	EPHA-mediated growth cone collapse	0.393149419094606	-0.933565538112519	34	31	0.00343148107150764	9034	10285	387,103910,7525,285220,79784,4629,1946,2042,3791,5747,9475,2043,3320,2534,1944,4628,7422,6461,2045,25791,4637,6714,284656,1942,4067,2046,1969,2044,10398,1943,4627	RHOA,MYL12B,YES1,EPHA6,MYH14,MYH11,EFNA5,EPHA3,KDR,PTK2,ROCK2,EPHA4,HSP90AA1,FYN,EFNA3,MYH10,VEGFA,SHB,EPHA7,NGEF,MYL6,SRC,EPHA10,EFNA1,LYN,EPHA8,EPHA2,EPHA5,MYL9,EFNA2,MYH9
R-HSA-5656169	Termination of translesion DNA synthesis	0.393149419094606	-0.933565538112519	34	31	0.00343148107150764	9034	10285	7314,7706,7318,9246,6119,124739,7316,51426,5983,7311,9100,100847079,5429,54107,57804,9636,5982,6233,5981,5111,5427,6118,51455,10714,5985,11201,5984,100500827,6117,5424,56655	UBB,TRIM25,UBA7,UBE2L6,RPA3,USP43,UBC,POLK,RFC3,UBA52,USP10,MIR5193,POLH,POLE3,POLD4,ISG15,RFC2,RPS27A,RFC1,PCNA,POLE2,RPA2,REV1,POLD3,RFC5,POLI,RFC4,MIR3614,RPA1,POLD1,POLE4
R-HSA-6802952	Signaling by BRAF and RAF fusions	0.393725329037563	-0.932101747217829	60	54	0.00597741864069072	9034	10285	80853,10256,408,2243,23499,8087,54845,5595,4893,9061,5605,283455,57670,3690,673,8826,409,9715,2335,10142,23164,7529,27044,3265,2266,56829,8546,11044,22906,7450,3717,5894,5594,5037,3674,4140,1445,57085,3845,5908,8805,5906,10827,10533,55750,6714,10018,2244,4000,55109,9444,5604,54518,7414	KDM7A,CNKSR1,ARRB1,FGA,MACF1,FXR1,ESRP1,MAPK3,NRAS,PAPSS1,MAP2K2,KSR2,KIAA1549,ITGB3,BRAF,IQGAP1,ARRB2,FAM131B,FN1,AKAP9,MPRIP,YWHAB,SND1,HRAS,FGG,ZC3HAV1,AP3B1,TENT4A,TRAK1,VWF,JAK2,RAF1,MAPK1,PEBP1,ITGA2B,MARK3,CSK,AGTRAP,KRAS,RAP1B,TRIM24,RAP1A,FAM114A2,ATG7,AGK,SRC,BCL2L11,FGB,LMNA,AGGF1,QKI,MAP2K1,APBB1IP,VCL
R-HSA-2262749	Cellular response to hypoxia	0.39664470465365	-0.924714349496819	77	69	0.00763781270754926	9034	10285	3091,7314,5687,126374,5685,5719,10370,2056,7428,5690,7323,5686,100302237,5702,55662,8994,5693,5695,7321,112398,5714,1387,5691,84962,5696,10213,5720,2034,5704,5698,5710,143471,5713,23198,9978,54583,6923,7316,7979,7311,5699,5692,10197,5700,2033,9491,122706,5684,768,7322,64344,6233,7422,5707,5701,5718,405,25994,5682,5715,8453,112399,5706,5717,5711,5708,9861,5694,6921	HIF1A,UBB,PSMA6,WTIP,PSMA4,PSMD13,CITED2,EPO,VHL,PSMB2,UBE2D3,PSMA5,MIR1281,PSMC3,HIF1AN,LIMD1,PSMB5,PSMB7,UBE2D1,EGLN2,PSMD8,CREBBP,PSMB3,AJUBA,PSMB8,PSMD14,PSME1,EPAS1,PSMC4,PSMB9,PSMD4,PSMA8,PSMD7,PSME4,RBX1,EGLN1,ELOB,UBC,SEM1,UBA52,PSMB10,PSMB4,PSME3,PSMC1,EP300,PSMF1,PSMB11,PSMA3,CA9,UBE2D2,HIF3A,RPS27A,VEGFA,PSMD1,PSMC2,PSMD12,ARNT,HIGD1A,PSMA1,PSMD9,CUL2,EGLN3,PSMC6,PSMD11,PSMD5,PSMD2,PSMD6,PSMB6,ELOC
R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen	0.39664470465365	-0.924714349496819	77	69	0.00763781270754926	9034	10285	5715,5682,5717,8453,112399,5706,6921,5694,9861,5711,5708,5707,6233,7422,25994,5701,5718,405,9491,2033,10197,5700,7311,5692,5699,7322,64344,122706,768,5684,143471,5710,6923,54583,7316,7979,23198,5713,9978,5720,2034,84962,10213,5696,5698,5704,112398,5695,7321,5691,5714,1387,5686,5702,100302237,7323,5690,5693,8994,55662,126374,5687,5719,5685,7314,3091,7428,2056,10370	PSMD9,PSMA1,PSMD11,CUL2,EGLN3,PSMC6,ELOC,PSMB6,PSMD6,PSMD5,PSMD2,PSMD1,RPS27A,VEGFA,HIGD1A,PSMC2,PSMD12,ARNT,PSMF1,EP300,PSME3,PSMC1,UBA52,PSMB4,PSMB10,UBE2D2,HIF3A,PSMB11,CA9,PSMA3,PSMA8,PSMD4,ELOB,EGLN1,UBC,SEM1,PSME4,PSMD7,RBX1,PSME1,EPAS1,AJUBA,PSMD14,PSMB8,PSMB9,PSMC4,EGLN2,PSMB7,UBE2D1,PSMB3,PSMD8,CREBBP,PSMA5,PSMC3,MIR1281,UBE2D3,PSMB2,PSMB5,LIMD1,HIF1AN,WTIP,PSMA6,PSMD13,PSMA4,UBB,HIF1A,VHL,EPO,CITED2
R-HSA-1606322	ZBP1(DAI) mediated induction of type I IFNs	0.398871134081189	-0.919116886486632	25	23	0.00254593756918309	9034	10285	3551,4792,3661,4790,3146,4793,177,5970,81030,23220,1147,147945,6283,148022,4615,29110,8737,11035,351,1660,4791,6288,7098	IKBKB,NFKBIA,IRF3,NFKB1,HMGB1,NFKBIB,AGER,RELA,ZBP1,DTX4,CHUK,NLRP4,S100A12,TICAM1,MYD88,TBK1,RIPK1,RIPK3,APP,DHX9,NFKB2,SAA1,TLR3
R-HSA-1251985	Nuclear signaling by ERBB4	0.398871134081189	-0.919116886486632	25	23	0.00254593756918309	9034	10285	2066,3084,83464,2670,23118,145957,10718,10413,1839,6776,6868,2099,685,51107,9611,2069,23385,1447,51741,5664,9542,5241,6387	ERBB4,NRG1,APH1B,GFAP,TAB2,NRG4,NRG3,YAP1,HBEGF,STAT5A,ADAM17,ESR1,BTC,APH1A,NCOR1,EREG,NCSTN,CSN2,WWOX,PSEN2,NRG2,PGR,CXCL12
R-HSA-982772	Growth hormone receptor signaling	0.398871134081189	-0.919116886486632	25	23	0.00254593756918309	9034	10285	9021,6776,6772,5618,6868,5594,8660,8835,3717,5777,3667,25970,6774,8651,2688,6777,1154,4067,5770,5595,2690,5617,1444	SOCS3,STAT5A,STAT1,PRLR,ADAM17,MAPK1,IRS2,SOCS2,JAK2,PTPN6,IRS1,SH2B1,STAT3,SOCS1,GH1,STAT5B,CISH,LYN,PTPN1,MAPK3,GHR,PRL,CSHL1
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	0.398871134081189	-0.919116886486632	25	23	0.00254593756918309	9034	10285	54107,5982,57804,51426,5983,7311,7316,7314,6119,5424,56655,5984,7515,6117,10714,6118,3980,5985,5111,5981,6233,3978,5427	POLE3,RFC2,POLD4,POLK,RFC3,UBA52,UBC,UBB,RPA3,POLD1,POLE4,RFC4,XRCC1,RPA1,POLD3,RPA2,LIG3,RFC5,PCNA,RFC1,RPS27A,LIG1,POLE2
R-HSA-5673000	RAF activation	0.398871134081189	-0.919116886486632	25	23	0.00254593756918309	9034	10285	5526,8315,673,5605,5528,5527,5525,5519,3265,6714,7529,5604,5894,5529,5515,3717,4140,5245,5516,3845,4296,5518,4893	PPP2R5B,BRAP,BRAF,MAP2K2,PPP2R5D,PPP2R5C,PPP2R5A,PPP2R1B,HRAS,SRC,YWHAB,MAP2K1,RAF1,PPP2R5E,PPP2CA,JAK2,MARK3,PHB1,PPP2CB,KRAS,MAP3K11,PPP2R1A,NRAS
R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer	0.398871134081189	-0.919116886486632	25	23	0.00254593756918309	9034	10285	253260,207,2931,1147,208,6199,1026,64223,79109,4193,2475,842,2308,3164,55615,10000,1027,1385,2932,84335,2309,7249,5170	RICTOR,AKT1,GSK3A,CHUK,AKT2,RPS6KB2,CDKN1A,MLST8,MAPKAP1,MDM2,MTOR,CASP9,FOXO1,NR4A1,PRR5,AKT3,CDKN1B,CREB1,GSK3B,AKT1S1,FOXO3,TSC2,PDPK1
R-HSA-383280	Nuclear Receptor transcription pathway	0.400972678527628	-0.913861987344311	51	46	0.00509187513836617	9034	10285	6258,10062,8431,9572,6256,3172,7068,3164,2103,4929,2100,7025,29959,3174,10002,2063,4306,2101,5915,7376,8013,7421,5469,7101,5241,5916,2649,5467,2908,2516,5465,6096,126382,2494,7181,6097,9970,6095,2099,5468,9975,29982,9971,8856,5914,2104	RXRG,NR1H3,NR0B2,NR1D1,RXRA,HNF4A,THRB,NR4A1,ESRRB,NR4A2,ESR2,NR2F1,NRBP1,HNF4G,NR2E3,NR2F6,NR3C2,ESRRA,RARB,NR1H2,NR4A3,VDR,MED1,NR2E1,PGR,RARG,NR6A1,PPARD,NR3C1,NR5A1,PPARA,RORB,NR2C2AP,NR5A2,NR2C1,RORC,NR1I3,RORA,ESR1,PPARG,NR1D2,NRBF2,NR1H4,NR1I2,RARA,ESRRG
R-HSA-448706	Interleukin-1 processing	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	4791,3552,3606,834,5970,4790,3553	NFKB2,IL1A,IL18,CASP1,RELA,NFKB1,IL1B
R-HSA-426496	Post-transcriptional silencing by small RNAs	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	192669,27327,27161,23112,57690,192670,26523	AGO3,TNRC6A,AGO2,TNRC6B,TNRC6C,AGO4,AGO1
R-HSA-2980767	Activation of NIMA Kinases NEK9, NEK6, NEK7	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	91754,983,891,9133,5347,140609,10783	NEK9,CDK1,CCNB1,CCNB2,PLK1,NEK7,NEK6
R-HSA-426117	Cation-coupled Chloride cotransporters	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	6559,10723,6557,57468,6560,9990,6558	SLC12A3,SLC12A7,SLC12A1,SLC12A5,SLC12A4,SLC12A6,SLC12A2
R-HSA-3656243	Defective ST3GAL3 causes MCT12 and EIEE15	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	11081,176,5549,4958,4060,4969,2331	KERA,ACAN,PRELP,OMD,LUM,OGN,FMOD
R-HSA-4411364	Binding of TCF/LEF:CTNNB1 to target gene promoters	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	83439,1499,6932,6934,4609,51176,8313	TCF7L1,CTNNB1,TCF7,TCF7L2,MYC,LEF1,AXIN2
R-HSA-3656244	Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	4060,4969,2331,11081,176,5549,4958	LUM,OGN,FMOD,KERA,ACAN,PRELP,OMD
R-HSA-5649702	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	11284,252969,5423,7515,79661,4968,3980	PNKP,NEIL2,POLB,XRCC1,NEIL1,OGG1,LIG3
R-HSA-3065678	SUMO is transferred from E1 to E2 (UBE2I, UBC9)	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	7341,7329,6612,10054,6613,25950,10055	SUMO1,UBE2I,SUMO3,UBA2,SUMO2,RWDD3,SAE1
R-HSA-3304349	Loss of Function of SMAD2/3 in Cancer	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	4088,7048,7040,7046,4089,4087,9372	SMAD3,TGFBR2,TGFB1,TGFBR1,SMAD4,SMAD2,ZFYVE9
R-HSA-164843	2-LTR circle formation	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	3159,2547,7518,11168,3981,7520,8815	HMGA1,XRCC6,XRCC4,PSIP1,LIG4,XRCC5,BANF1
R-HSA-190371	FGFR3b ligand binding and activation	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	26281,8817,8822,2261,2253,2254,2246	FGF20,FGF18,FGF17,FGFR3,FGF8,FGF9,FGF1
R-HSA-83936	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	55315,222962,64078,2030,9153,9154,3177	SLC29A3,SLC29A4,SLC28A3,SLC29A1,SLC28A2,SLC28A1,SLC29A2
R-HSA-174362	Transport and synthesis of PAPS	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	51000,1836,9061,9060,10861,347734,100616124	SLC35B3,SLC26A2,PAPSS1,PAPSS2,SLC26A1,SLC35B2,MIR4647
R-HSA-73943	Reversal of alkylation damage by DNA dioxygenases	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	54890,84164,221120,51008,121642,79068,10973	ALKBH5,ASCC2,ALKBH3,ASCC1,ALKBH2,FTO,ASCC3
R-HSA-629587	Highly sodium permeable acetylcholine nicotinic receptors	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	1144,1143,1141,1136,1137,1145,1146	CHRND,CHRNB4,CHRNB2,CHRNA3,CHRNA4,CHRNE,CHRNG
R-HSA-5652084	Fructose metabolism	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	231,3795,216,26007,229,6652,132158	AKR1B1,KHK,ALDH1A1,TKFC,ALDOB,SORD,GLYCTK
R-HSA-3656225	Defective CHST6 causes MCDC1	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	2331,4969,4060,4958,5549,176,11081	FMOD,OGN,LUM,OMD,PRELP,ACAN,KERA
R-HSA-75158	TRAIL  signaling	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	841,843,8837,8743,8797,8772,8795	CASP8,CASP10,CFLAR,TNFSF10,TNFRSF10A,FADD,TNFRSF10B
R-HSA-442720	CREB phosphorylation through the activation of Adenylate Cyclase	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	114,5568,1385,109,107,5567,5566	ADCY8,PRKACG,CREB1,ADCY3,ADCY1,PRKACB,PRKACA
R-HSA-3315487	SMAD2/3 MH2 Domain Mutants in Cancer	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	7040,7046,4089,9372,4087,7048,4088	TGFB1,TGFBR1,SMAD4,ZFYVE9,SMAD2,TGFBR2,SMAD3
R-HSA-182218	Nef Mediated CD8 Down-regulation	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	926,1173,163,160,161,1175,51606	CD8B,AP2M1,AP2B1,AP2A1,AP2A2,AP2S1,ATP6V1H
R-HSA-196791	Vitamin D (calciferol) metabolism	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	8029,2638,4036,5641,120227,1591,1594	CUBN,GC,LRP2,LGMN,CYP2R1,CYP24A1,CYP27B1
R-HSA-435368	Zinc efflux and compartmentalization by the SLC30 family	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	7779,64924,55676,148867,169026,7780,7781	SLC30A1,SLC30A5,SLC30A6,SLC30A7,SLC30A8,SLC30A2,SLC30A3
R-HSA-420597	Nectin/Necl  trans heterodimerization	0.403280926503263	-0.908121871791082	7	7	0.000774850564533983	9034	10285	5817,81607,5819,25945,5818,57863,23705	PVR,NECTIN4,NECTIN2,NECTIN3,NECTIN1,CADM3,CADM1
R-HSA-1834941	STING mediated induction of host immune responses	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	29110,6778,340061,2547,6737,3428,3661,147945,11277,7520,23220,4361,5591,197358,115004	TBK1,STAT6,STING1,XRCC6,TRIM21,IFI16,IRF3,NLRP4,TREX1,XRCC5,DTX4,MRE11,PRKDC,NLRC3,CGAS
R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	9091,5283,54872,84720,5279,9488,284098,23556,9487,54965,93183,5281,8818,55650,51227	PIGQ,PIGH,PIGG,PIGO,PIGC,PIGB,PIGW,PIGN,PIGL,PIGX,PIGM,PIGF,DPM2,PIGV,PIGP
R-HSA-5686938	Regulation of TLR by endogenous ligand	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	929,3146,23643,338,3929,7097,10333,2243,2244,948,2266,6280,7096,7099,6279	CD14,HMGB1,LY96,APOB,LBP,TLR2,TLR6,FGA,FGB,CD36,FGG,S100A9,TLR1,TLR4,S100A8
R-HSA-8866910	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	7422,1081,7021,29028,2099,7039,94115,1956,93659,2064,7020,7022,3815,7528,1082	VEGFA,CGA,TFAP2B,ATAD2,ESR1,TGFA,CGB8,EGFR,CGB5,ERBB2,TFAP2A,TFAP2C,KIT,YY1,CGB3
R-HSA-159418	Recycling of bile acids and salts	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	8714,10499,213,6555,28234,8648,570,2172,80765,6554,8647,6579,6256,9971,10599	ABCC3,NCOA2,ALB,SLC10A2,SLCO1B3,NCOA1,BAAT,FABP6,STARD5,SLC10A1,ABCB11,SLCO1A2,RXRA,NR1H4,SLCO1B1
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	353376,7189,10454,7099,23118,7098,7311,7316,148022,6885,23643,929,6233,7314,3656	TICAM2,TRAF6,TAB1,TLR4,TAB2,TLR3,UBA52,UBC,TICAM1,MAP3K7,LY96,CD14,RPS27A,UBB,IRAK2
R-HSA-1295596	Spry regulation of FGF signaling	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	6714,7311,5516,5595,2885,5518,10253,7314,6233,673,5515,867,5594,5781,7316	SRC,UBA52,PPP2CB,MAPK3,GRB2,PPP2R1A,SPRY2,UBB,RPS27A,BRAF,PPP2CA,CBL,MAPK1,PTPN11,UBC
R-HSA-190242	FGFR1 ligand binding and activation	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	2251,2246,2249,2260,9365,2255,27006,26281,2248,2253,2254,8074,2247,8822,2250	FGF6,FGF1,FGF4,FGFR1,KL,FGF10,FGF22,FGF20,FGF3,FGF8,FGF9,FGF23,FGF2,FGF17,FGF5
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	0.40352797947632	-0.907509451727426	16	15	0.00166039406685853	9034	10285	79155,23291,7314,6233,7316,4790,3551,1147,8454,7311,6500,5604,1326,6416,8945	TNIP2,FBXW11,UBB,RPS27A,UBC,NFKB1,IKBKB,CHUK,CUL1,UBA52,SKP1,MAP2K1,MAP3K8,MAP2K4,BTRC
R-HSA-5685942	HDR through Homologous Recombination (HRR)	0.404066250302045	-0.906176428569054	68	61	0.00675226920522471	9034	10285	23514,144715,5810,5424,79728,672,9156,580,5984,5892,10714,641,5884,57804,11073,5982,675,5429,1111,51426,472,5889,84126,6119,4683,7486,7314,56655,4361,10111,83990,6117,7517,5985,545,10635,6118,5890,197342,5427,5981,6233,3364,7516,5111,5888,1763,83695,7156,54107,348654,10524,146956,116028,5983,7311,80010,7316,51750,84464,5883	SPIDR,RAD9B,RAD1,POLD1,PALB2,BRCA1,EXO1,BARD1,RFC4,RAD51D,POLD3,BLM,RAD17,POLD4,TOPBP1,RFC2,BRCA2,POLH,CHEK1,POLK,ATM,RAD51C,ATRIP,RPA3,NBN,WRN,UBB,POLE4,MRE11,RAD50,BRIP1,RPA1,XRCC3,RFC5,ATR,RAD51AP1,RPA2,RAD51B,EME2,POLE2,RFC1,RPS27A,HUS1,XRCC2,PCNA,RAD51,DNA2,RHNO1,TOP3A,POLE3,GEN1,KAT5,EME1,RMI2,RFC3,UBA52,RMI1,UBC,RTEL1,SLX4,RAD9A
R-HSA-3906995	Diseases associated with O-glycosylation of proteins	0.412139945132866	-0.886392314655719	59	53	0.00586672570290016	9034	10285	10071,80731,4855,11093,81794,4583,79875,143662,92949,56667,9509,23145,157869,80070,10417,170692,140453,4585,10418,55901,56999,4588,170689,140766,4853,221981,170690,170691,81792,9510,200958,11174,54437,171019,4854,4589,94025,118430,727897,9507,7057,54507,11173,9037,11095,9508,7058,1605,11096,9719,394263,339366,57188	MUC12,THSD7B,NOTCH4,ADAMTS13,ADAMTS10,MUC2,THSD4,MUC15,ADAMTSL1,MUC13,ADAMTS2,SSPOP,SBSPON,ADAMTS20,SPON2,ADAMTS18,MUC17,MUC4,SPON1,THSD1,ADAMTS9,MUC6,ADAMTS15,ADAMTS14,NOTCH2,THSD7A,ADAMTS16,ADAMTS17,ADAMTS12,ADAMTS1,MUC20,ADAMTS6,SEMA5B,ADAMTS19,NOTCH3,MUC7,MUC16,MUCL1,MUC5B,ADAMTS4,THBS1,ADAMTSL4,ADAMTS7,SEMA5A,ADAMTS8,ADAMTS3,THBS2,DAG1,ADAMTS5,ADAMTSL2,MUC21,ADAMTSL5,ADAMTSL3
R-HSA-168181	Toll Like Receptor 7/8 (TLR7/8) Cascade	0.412607236426752	-0.885259139897836	93	83	0.00918751383661722	9034	10285	7314,466,1846,64127,929,4214,79155,51295,5515,148022,51231,5594,57162,1848,9261,5602,5609,7098,5516,6288,8454,4791,5518,7867,10454,7189,246330,6416,8767,2353,7334,5599,6195,4793,4790,1385,3551,170506,1432,6283,6196,23118,1386,51135,5604,6500,1326,3656,54106,4205,5598,57161,7316,4615,7311,1660,5600,4208,5595,9252,351,353376,6233,10392,3146,1849,23643,3665,6885,23291,4792,5528,5601,5606,5519,1147,3725,5970,7099,8945,177,5608,7335	UBB,ATF1,DUSP4,NOD2,CD14,MAP3K1,TNIP2,ECSIT,PPP2CA,TICAM1,VRK3,MAPK1,PELI1,DUSP6,MAPKAPK2,MAPK10,MAP2K7,TLR3,PPP2CB,SAA1,CUL1,NFKB2,PPP2R1A,MAPKAPK3,TAB1,TRAF6,PELI3,MAP2K4,RIPK2,FOS,UBE2N,MAPK8,RPS6KA1,NFKBIB,NFKB1,CREB1,IKBKB,DHX36,MAPK14,S100A12,RPS6KA2,TAB2,ATF2,IRAK4,MAP2K1,SKP1,MAP3K8,IRAK2,TLR9,MEF2A,MAPK7,PELI2,UBC,MYD88,UBA52,DHX9,MAPK11,MEF2C,MAPK3,RPS6KA5,APP,TICAM2,RPS27A,NOD1,HMGB1,DUSP7,LY96,IRF7,MAP3K7,FBXW11,NFKBIA,PPP2R5D,MAPK9,MAP2K3,PPP2R1B,CHUK,JUN,RELA,TLR4,BTRC,AGER,MAP2K6,UBE2V1
R-HSA-975155	MyD88 dependent cascade initiated on endosome	0.412607236426752	-0.885259139897836	93	83	0.00918751383661722	9034	10285	148022,51231,5594,57162,1848,7314,466,64127,1846,929,4214,79155,51295,5515,5518,7867,10454,7189,246330,6416,8767,9261,5602,5609,5516,7098,6288,8454,4791,4790,1385,3551,170506,2353,7334,5599,6195,4793,1386,51135,6500,5604,1326,1432,6283,6196,23118,4205,5598,57161,4615,7316,3656,54106,9252,351,353376,7311,1660,5600,4208,5595,4792,5528,5601,6233,1849,3146,10392,23643,3665,6885,23291,5970,8945,7099,177,5608,7335,5606,5519,1147,3725	TICAM1,VRK3,MAPK1,PELI1,DUSP6,UBB,ATF1,NOD2,DUSP4,CD14,MAP3K1,TNIP2,ECSIT,PPP2CA,PPP2R1A,MAPKAPK3,TAB1,TRAF6,PELI3,MAP2K4,RIPK2,MAPKAPK2,MAPK10,MAP2K7,PPP2CB,TLR3,SAA1,CUL1,NFKB2,NFKB1,CREB1,IKBKB,DHX36,FOS,UBE2N,MAPK8,RPS6KA1,NFKBIB,ATF2,IRAK4,SKP1,MAP2K1,MAP3K8,MAPK14,S100A12,RPS6KA2,TAB2,MEF2A,MAPK7,PELI2,MYD88,UBC,IRAK2,TLR9,RPS6KA5,APP,TICAM2,UBA52,DHX9,MAPK11,MEF2C,MAPK3,NFKBIA,PPP2R5D,MAPK9,RPS27A,DUSP7,HMGB1,NOD1,LY96,IRF7,MAP3K7,FBXW11,RELA,BTRC,TLR4,AGER,MAP2K6,UBE2V1,MAP2K3,PPP2R1B,CHUK,JUN
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	0.412607236426752	-0.885259139897836	93	83	0.00918751383661722	9034	10285	545,5985,112858,6118,6881,6233,6794,3364,5565,4361,22974,10111,6873,6117,83990,204851,8445,6749,80010,7316,7157,9891,1263,1459,5883,6877,6875,4194,5563,83695,6883,8851,7156,1763,1017,5571,10524,116028,6880,5983,7311,5600,890,100302168,28996,11200,641,5884,4193,144715,5564,5810,6884,138474,8900,672,5984,1432,6879,9156,1457,580,83860,6790,94241,5300,84126,9212,4683,6119,7486,7314,11073,11198,5982,6874,1020,53632,51422,6882,1111,5562,472	ATR,RFC5,TP53RK,RPA2,TAF10,RPS27A,STK11,HUS1,PRKAB2,MRE11,TPX2,RAD50,TAF2,RPA1,BRIP1,HIPK1,DYRK2,SSRP1,RMI1,UBC,TP53,NUAK1,PLK3,CSNK2A2,RAD9A,TAF5,TAF4B,MDM4,PRKAA2,RHNO1,TAF12,CDK5R1,TOP3A,DNA2,CDK2,PRKAG1,KAT5,RMI2,TAF9,RFC3,UBA52,MAPK11,CCNA2,MIR1257,HIPK2,CHEK2,BLM,RAD17,MDM2,RAD9B,PRKAB1,RAD1,TAF13,TAF1L,CCNA1,BRCA1,RFC4,MAPK14,TAF7,EXO1,CSNK2A1,BARD1,TAF3,AURKA,TP53INP1,PIN1,ATRIP,AURKB,NBN,RPA3,WRN,UBB,TOPBP1,SUPT16H,RFC2,TAF4,CDK5,PRKAG3,PRKAG2,TAF11,CHEK1,PRKAA1,ATM
R-HSA-1266738	Developmental Biology	0.415644598498472	-0.877924714401708	1075	947	0.104826212087669	9034	10285	4747,80031,388,51107,85291,3983,2596,83899,10213,3880,5698,1050,6655,785,284217,25984,100533177,1825,3866,79784,3887,8128,3848,10094,2051,5266,4763,5788,9462,10368,85293,5747,140258,5922,4684,3849,8826,4897,6711,9043,1830,10142,3688,25791,8218,10718,6925,57472,389692,2906,5105,5711,3815,55740,60,93,2044,5439,4902,1499,6334,8361,1175,6699,152559,8976,5595,6386,2033,71,112950,5652,5699,1944,5684,9353,8315,6195,6704,137970,4628,10298,1956,5318,3200,1823,11202,55715,5704,353332,3326,10156,8349,221002,28964,23380,3568,4318,10589,1282,3861,7528,1742,3985,1285,653604,57113,2247,9846,3728,219699,5525,1173,83464,7529,5608,5970,2675,3232,100126325,391,6478,337880,5159,4629,10486,5923,10197,8348,9440,8366,10817,998,2263,337979,1759,2065,8074,6720,161,9260,8660,5720,2244,288,818,3713,4209,8352,10664,9693,64096,100847012,8202,27255,4756,3853,63978,85280,7222,2887,8912,4087,5707,5567,823,7225,3673,5080,8355,10154,5441,2146,148738,3265,81872,6323,6707,6586,85290,8440,6700,408,337976,337879,5700,7074,4208,9070,2251,25780,5087,9475,2047,192666,337971,6330,79447,3672,1843,3855,4790,390874,8913,84891,284656,10498,116986,57731,79727,91,337960,386676,1041,5687,8817,5894,5469,337973,387264,8515,5364,9037,3020,337975,5518,27092,8726,3211,8841,3690,1793,5468,9826,5519,254910,53358,115727,775,971,400569,8353,3884,386679,6299,27,7223,83897,3651,10096,3852,337970,286,3021,816,5714,254950,5295,3858,6714,6329,784,23332,5515,387,9125,8648,1445,80824,8687,337963,399473,23254,723790,6331,8364,27022,23385,3718,8649,2668,353131,4067,5706,2516,5465,5566,23054,8986,779,63925,23512,94239,10097,83896,7305,64926,214,10256,10818,4618,6328,3892,896,3859,9439,2046,128312,1272,2904,3172,730755,337969,8359,6336,1848,5293,10000,5686,55090,59277,6721,1946,8482,5915,3786,1849,2250,25818,2335,353139,5701,8358,1024,10891,6701,145957,808,200734,1969,10499,8370,1297,126961,5045,57830,3175,5440,4205,9491,337966,7410,64344,643812,6237,2069,284827,3860,2932,100271849,92,23129,5155,7414,5529,102,7525,7450,2254,199699,4838,3201,3375,5433,287,6092,56896,6768,84616,90249,5693,3886,1211,817,1020,728255,3516,3562,5058,663,5605,59283,4637,9441,10369,8502,3221,5528,8970,3725,51466,11187,1000,57556,140807,7903,1437,9048,8345,5664,4821,10487,9370,27006,4023,3017,3082,8503,5695,1385,2050,5879,4313,5536,1495,84962,55800,160,5623,286887,9542,1051,3881,22885,6929,5037,1950,85285,5245,5908,3845,5313,1828,1809,9612,3320,5929,64065,386685,9967,10752,100131902,6928,81857,685,8343,3685,5717,5928,8360,1808,386683,2246,1829,5909,1072,5432,5710,143471,1459,8367,5361,147183,6456,5598,23198,11005,10001,23097,5692,386681,6710,9252,8334,8851,79923,26239,64221,10974,3560,256297,3012,387273,5317,9333,1432,390792,7471,54518,4627,8452,5979,3231,1002,7026,8822,91653,4656,80205,57698,319101,3567,85441,3174,1850,2249,5906,168544,23114,2905,409,783,2266,5216,1785,375790,2248,8363,56924,2125,9412,8340,440051,8997,5914,153090,1400,776,5713,388818,8347,948,100132476,7311,5600,26281,3015,1879,6477,805,9723,11313,4690,1839,1387,6196,6464,728299,1475,8362,6938,5430,728318,256076,163,1630,353137,100302237,8745,4651,5690,90390,3888,8650,6712,58508,5921,5526,85289,9965,3013,7408,161742,2261,5715,1286,84292,285704,3889,5493,6383,3680,337967,6514,8365,892,9046,7316,5578,4211,5346,2676,121504,2903,10371,10095,55211,11091,3851,9935,54756,55766,27040,7703,1019,3875,7124,386682,57522,2066,1463,2048,5062,3558,8335,5290,96764,389,1846,8874,208,222546,91584,6517,2534,1948,3890,57167,6233,2253,353145,374454,83901,6585,5434,337978,23389,1949,5694,1293,8682,4233,5460,1796,5880,688,728279,54797,643803,2049,54474,3559,1739,9365,3280,28956,3872,337882,6604,7480,4185,4917,53616,643394,2252,353288,83902,23581,5306,284,5604,6256,3856,100132386,57144,11280,386678,162605,6709,2649,801,8344,3716,23365,4089,10451,8911,27332,50674,283455,10048,5154,6708,2167,7010,10109,3084,3170,5568,27289,4088,5708,10507,10125,338785,2255,6326,5296,2309,3312,131873,2034,1299,1943,3199,50937,1284,7040,7314,4140,5516,5702,3630,1847,2674,2885,100505753,4296,2043,673,1013,2817,353333,8357,6705,2549,2645,9423,100288323,8350,2308,3984,3171,728224,9978,3952,7220,3198,80306,1298,9477,55997,3891,2045,3857,5924,51350,43849,81851,5291,2264,439915,5685,199834,3717,5962,353323,5916,5335,5594,8688,6300,6335,51129,9901,3850,6461,6654,6332,8968,5588,337968,9211,5682,8339,1942,3785,2494,125115,8689,196374,4654,51586,6327,4617,7062,220164,2042,5046,130399,1824,342574,85294,56963,6900,5691,25,5156,1832,10093,1213,1457,11221,207,22976,25759,10627,5362,8437,5316,6657,5431,5719,64218,103910,126638,3674,3885,5781,9969,3642,112755,5217,10552,6774,9611,8633,7422,6453,29079,26052,440023,5718,3854,387266,7430,6927,63036,23396,84078,3882,1052,203190,337972,653240,43847,386674,1959,83895,2260,23122,4254,2243,10025,55203,337977,8368,9443,3791,144501,8346,1496,386677,8831,8354,386672,337974,1439,3883,337959,5696,147409,7051,3846,285220,8829,3868,5621,285643,121391,9442,5786,2909,4760,55816,2242,3912,815,51332,3667,1212,5078,9314,7044,6091,3915,8828,9063,404203,64283,5527,2064,26085,9861,10398,10637,27086,8341,79718,4825,3018,112802,440050,1844,7979,4014,88,9350,84246,6997,10092,219541,7204,84448,122706,4893,51003	NEFL,SEMA6D,RHOB,APH1A,KRTAP4-2,ABLIM1,GAP43,KRTAP9-2,PSMD14,KRT19,PSMB9,CEBPA,SOS2,CACNB4,LAMA1,KRT23,KRTAP29-1,DSC3,KRT15,MYH14,KRT81,ST8SIA2,KRT1,ARPC3,EPHB6,PI3,NF1,PTPRC,RASAL2,CACNG3,KRTAP3-3,PTK2,KRTAP13-1,RASA2,NCAM1,KRT2,IQGAP1,NRCAM,SPTBN1,SPAG9,DSG3,AKAP9,ITGB1,NGEF,CLTCL1,NRG3,TCF4,CNOT6,MAFA,GRIN2D,PCK1,PSMD5,KIT,ENAH,ACTB,ACVR2B,EPHA5,POLR2J,NRTN,CTNNB1,SCN8A,H4C6,AP2S1,SPRR1B,PAQR3,WASL,MAPK3,SDCBP,EP300,ACTG1,MED8,PRSS8,PSMB10,EFNA3,PSMA3,SLIT2,BRAP,RPS6KA1,SPRR2E,UNC5D,MYH10,PAK4,EGFR,PKP2,HOXA3,DSC1,KLK8,DOK4,PSMC4,KRTAP12-1,HSP90AB1,RASA4,H2BC21,RASGEF1A,GIT1,SRGAP2,IL5RA,MMP9,DRAP1,COL4A1,KRT14,YY1,DLG4,LIMK2,COL4A3,H3C13,TRPC7,FGF2,GAB2,JUP,UNC5B,PPP2R5A,AP2M1,APH1B,YWHAB,MAP2K6,RELA,GFRA2,HOXD3,MIR935,RHOG,SIAH2,KRTAP11-1,PDGFRB,MYH11,CAP2,RASGRF1,PSME3,H2BC17,MED17,H4C2,FRS3,CDC42,FGFR2,KRTAP22-1,DNM1,ERBB3,FGF23,SREBF1,AP2A2,PDLIM7,IRS2,PSME1,FGB,ANK3,CAMK2G,IVL,MEF2D,H3C3,CTCF,RAPGEF2,GFRA4,MIR5004,NCOA3,CNTN6,NEO1,KRT6A,PRDM14,KRTAP9-4,TRPC3,GRB10,CACNA1H,SMAD2,PSMD1,PRKACB,CAPN1,TRPC6,ITGA2,PAX6,H3C8,PLXNC1,POLR2L,EZH2,HJV,HRAS,KRTAP2-1,SCN1A,SPRR3,SLIT3,KRTAP4-3,NCK2,SPRR2A,ARRB1,KRTAP20-2,KRTAP8-1,PSMC1,TIAM1,MEF2C,ASH2L,FGF6,RASGRP3,PBX1,ROCK2,EPHB1,KRT24,KRTAP19-4,SCN4B,PAGR1,ITGA1,DUSP1,KRT7,NFKB1,ONECUT3,CACNA1G,ZSCAN10,EPHA10,CARM1,AGAP2,SPTBN4,LIN28A,ACVR1B,KRTAP13-3,KRTAP10-9,CDSN,PSMA6,FGF18,RAF1,MED1,KRTAP19-6,KRTAP5-1,ITGA10,PLXNB1,SEMA5A,H3-3A,KRTAP20-1,PPP2R1A,CACNG4,EED,HOXB1,HDAC3,ITGB3,DOCK1,PPARG,ARHGEF11,PPP2R1B,LCE5A,SHC3,RASGRP4,CACNA1C,CD72,MED11,H3C6,KRT33B,KRTAP10-2,SALL1,ABL2,TRPC4,KRTAP3-2,PDX1,ACTR3,KRT5,KRTAP19-3,ANK1,H3-3B,CAMK2B,PSMD8,KRTAP15-1,PIK3R1,KRT10,SRC,SCN4A,CACNB3,CLASP1,PPP2CA,RHOA,CNOT9,NCOA1,CSK,DUSP16,KRT38,KRTAP23-1,SPRED3,KAZN,H2AC19,SCN5A,H4C3,FOXD3,NCSTN,JAK3,LAMTOR3,GDNF,LCE1A,LYN,PSMC6,NR5A1,PPARA,PRKACA,NCOA6,RPS6KA4,CACNA1S,ZNF335,SUZ12,H2AZ2,ACTR2,KRTAP3-1,TYROBP,RASAL3,ALCAM,CNKSR1,FRS2,MYF6,SCN3A,KRT86,CCND3,KRT12,MED23,EPHA8,H2BC26,CNTN1,GRIN2B,HNF4A,KRTAP2-3,KRTAP19-2,H4C1,SCN10A,DUSP6,PIK3CD,AKT3,PSMA5,MED9,NTN4,SREBF2,EFNA5,SEMA7A,RARB,KCNQ3,DUSP7,FGF5,KLK5,FN1,LCE2A,PSMC2,H3C2,CDK8,PPARGC1A,SPRR2B,NRG4,CALM3,SPRED2,EPHA2,NCOA2,H4C14,COL9A1,H3C14,FURIN,KRTAP5-8,ONECUT1,POLR2K,MEF2A,PSMF1,KRTAP6-1,VAV2,HIF3A,KRTAP27-1,RRAS,EREG,KRTAP13-4,KRT13,GSK3B,MEF2B,ACVR2A,PLXND1,PDGFB,VCL,PPP2R5E,ADAM10,YES1,VWF,FGF9,DAND5,NODAL,HOXA4,IAPP,POLR2D,ANK2,ROBO2,DPYSL5,ST14,KRTAP4-4,UNC5A,PSMB5,KRT35,CLTA,CAMK2D,CDK5,KRTAP1-4,RBPJ,IL3,PAK1,BNIP2,MAP2K2,CACNG8,MYL6,MED26,CACNG2,PKP4,HOXC4,PPP2R5D,H2BC11,JUN,EVL,PKP3,CDH2,SEMA6A,KRT72,ST8SIA4,CSF2,ARTN,H2BC9,PSEN2,NKX2-2,CAP1,ADIPOQ,FGF22,LPL,H2BC5,HGF,PIK3R3,PSMB7,CREB1,EPHB4,RAC1,MMP2,PPP5C,CTNNA1,AJUBA,SCN3B,AP2A1,PSPN,KRT6C,NRG2,CEBPB,KRT31,ABLIM3,TCF3,PEBP1,EGF,KRTAP4-1,PHB1,RAP1B,KRAS,PKLR,DSG1,DPYSL3,NCOR2,HSP90AA1,RBBP5,PERP,KRTAP10-12,THRAP3,CHL1,KRTAP25-1,HNF1B,MED25,BTC,H2BC7,ITGAV,PSMD11,RBBP4,H4C4,DPYSL2,KRTAP12-3,FGF1,DSG2,RAP1GAP,CFL1,POLR2C,PSMD4,PSMA8,CSNK2A2,H4C5,PLXNA1,KRT25,SH3GL2,MAPK7,PSME4,SPINK5,MED6,CDK19,PSMB4,KRTAP10-8,SPTB,RPS6KA5,H2AC6,CDK5R1,NANOG,LCE2B,ROBO3,ADIRF,IL2RB,PTF1A,H2AC8,KRTAP5-10,PKP1,TGM5,MAPK14,KRT39,WNT1,APBB1IP,MYH9,CUL3,RET,HOXD1,CDH4,NR2F2,FGF17,BOC,MYOG,CHD9,SHTN1,KRT73,IL5,HELZ2,HNF4G,DUSP8,FGF4,RAP1A,ZNF467,NFASC,GRIN2C,ARRB2,CACNB2,FGG,PFN1,DNM2,AGRN,FGF3,H4C11,PAK6,EVPL,MED21,H2BC13,KRTAP5-11,KALRN,RARA,DAB2IP,CRMP1,CACNA1D,PSMD7,KRTAP26-1,H2BC4,CD36,KRTAP4-7,UBA52,MAPK11,FGF20,H2AZ1,EBF1,SIAH1,CALM2,SEMA3E,LYPLA2,NCK1,HBEGF,CREBBP,RPS6KA2,SHC1,KRTAP19-8,CSTA,H4C12,TCF12,POLR2A,KRTAP9-1,COL6A5,AP2B1,DCC,LCE1F,MIR1281,ADAM23,MYO10,PSMB2,MED30,KRT82,NUMB,SPTBN2,KMT2C,RASA1,PPP2R5B,KRTAP4-5,FGF19,H2AC7,VASP,SPRED1,FGFR3,PSMD9,COL4A4,WDR83,RGMB,KRT83,PPL,SDC2,ITGA9,KRTAP6-2,SLC2A2,H4C8,CCNC,DOK2,UBC,PRKCA,MEIS1,PLIN1,GFRA3,H4C16,GRIN2A,SEMA3A,ARPC1B,DPPA4,WDR5,KRT4,MAFB,IL17RD,H2AJ,LAT,PCGF2,CDK4,KRT18,TNF,KRTAP10-3,SRGAP1,ERBB4,NCAN,EPHB2,PAK2,IL2,H2AC4,PIK3CA,TGS1,RHOC,DUSP4,ARHGEF7,AKT2,RFX6,PLXNA4,SLC2A4,FYN,EFNB2,KRT84,SALL4,RPS27A,FGF8,LCE3E,KRT77,KRTAP9-8,SLIT1,POLR2E,KRTAP21-2,MED13L,EFNB3,PSMB6,COL6A3,PEA15,MET,POU5F1,DOK1,RAC2,KLF5,KRTAP2-2,MED18,KRTAP24-1,EPHB3,KRT20,IL2RA,DLG1,KL,HES1,LAMTOR2,KRT17,KRTAP19-1,SMARCD3,WNT10B,ADAM11,NTN3,ADAM22,SPINK9,FGF7,KRT26,KRTAP17-1,CASP14,PITPNA,ANGPT1,MAP2K1,RXRA,KRT8,KRTAP4-9,PAK5,SCN11A,KRTAP10-11,KRT28,SPTAN1,NR6A1,CALM1,H2BC6,JAK1,ARHGEF12,SMAD4,VAV3,CACNA1I,ZNF638,NEUROG3,KSR2,RANBP9,PDGFA,SPTA1,FABP4,TEK,ARPC2,NRG1,FOXA2,PRKACG,RND1,SMAD3,PSMD2,SEMA4D,RASGRP1,KRT79,FGF10,SCN2A,PIK3R2,FOXO3,HSPA8,COL6A6,EPAS1,COL9A3,EFNA2,HOXA2,CDON,COL4A2,TGFB1,UBB,MARK3,PPP2CB,PSMC3,INS,DUSP5,GFRA1,GRB2,KRTAP16-1,MAP3K11,EPHA4,BRAF,CDH15,GPC1,KRTAP10-10,H3C10,SPRR2F,GAB1,GCK,NTN1,KRTAP21-3,H3C1,FOXO1,LIMK1,FOXA3,KRTAP4-8,RBX1,LEP,TRPC1,HOXA1,MED28,COL9A2,MED20,CFC1,KRT85,EPHA7,KRT9,RASGRF2,KRT76,KLK12,KRTAP1-1,PIK3CB,FGFR4,KRTAP5-5,PSMA4,LCE4A,JAK2,RDX,KRTAP12-2,RARG,PLCG1,MAPK1,KRT37,MAPK12,SCN9A,ANGPTL4,SRGAP3,KRT3,SHB,SOS1,SCN7A,H3C7,PRKCQ,KRTAP6-3,LGI1,PSMA1,H2BC8,EFNA1,KCNQ2,NR5A2,KRT40,KRT36,KRT78,MYOD1,MED15,SCN2B,MYF5,TCHH,DOK6,EPHA3,PCSK6,ACVR1C,DSC2,KRT27,KRTAP2-4,RGMA,CNTN2,PSMB3,ABL1,PDGFRA,DSP,ARPC4,CLTC,CSNK2A1,DUSP10,AKT1,PAXIP1,SHC2,MYL12A,PLXNA2,RASAL1,PKNOX1,SOX2,POLR2B,PSMD13,SEMA4A,MYL12B,RPTN,ITGA2B,KRT34,PTPN11,MED13,INSM1,STX1B,PFN2,ARPC1A,STAT3,NCOR1,UNC5C,VEGFA,ITSN1,MED4,DNM3,KRTAP5-6,PSMD12,KRT6B,KRTAP5-3,EZR,HNF1A,CELA2A,PIP5K1C,KBTBD7,KRT32,CEBPD,LGI3,KRTAP19-5,KRTAP4-11,KLK14,KRTAP10-6,EGR2,KRTAP1-5,FGFR1,CLASP2,KITLG,FGA,MED16,LGI2,KRTAP21-1,H4C13,MED7,KDR,KRT80,H2BC10,CTNNA2,KRTAP10-1,SYNGAP1,H3C11,KRTAP10-4,KRTAP19-7,CSF2RB,KRT33A,KRTAP13-2,PSMB8,DSG4,TGM1,KRTAP5-9,EPHA6,NRP1,KRT16,PRNP,KIF4B,KRT74,MED27,PTPRA,ARHGAP35,NEUROD1,DOK5,FES,LAMB1,CAMK2A,SPTBN5,IRS1,CLTB,PAX4,KLF4,LEFTY2,ROBO1,LAMC1,NRP2,PIAS2,SPINK6,ARHGEF28,PPP2R5C,ERBB2,KLK13,PSMD6,MYL9,LEFTY1,FOXP1,H2BC15,TBL1XR1,NKX6-1,H2BC3,KRT71,KRTAP5-7,DUSP2,SEM1,LORICRIN,ACTN2,CER1,MED10,CRIPTO,ARPC5,MED19,TRIO,ABLIM2,PSMB11,NRAS,MED31
R-HSA-4085001	Sialic acid metabolism	0.417586823860122	-0.873262794970579	33	30	0.00332078813371707	9034	10285	10020,140838,10559,6489,6480,81849,6482,8128,30815,27090,7903,10610,51046,80896,4758,6483,55907,2720,8869,256435,10402,26503,338596,6484,6487,29906,84620,54187,55808,10825	GNE,NANP,SLC35A1,ST8SIA1,ST6GAL1,ST6GALNAC5,ST3GAL1,ST8SIA2,ST6GALNAC6,ST6GALNAC4,ST8SIA4,ST6GALNAC2,ST8SIA3,NPL,NEU1,ST3GAL2,CMAS,GLB1,ST3GAL5,ST6GALNAC3,ST3GAL6,SLC17A5,ST8SIA6,ST3GAL4,ST3GAL3,ST8SIA5,ST6GAL2,NANS,ST6GALNAC1,NEU3
R-HSA-1660499	Synthesis of PIPs at the plasma membrane	0.421056712442177	-0.864987745483402	50	45	0.0049811822005756	9034	10285	22874,8871,79837,146850,84725,8897,51552,27124,8821,375,23396,59338,5868,8395,5294,5867,64419,8867,9107,8396,55300,5728,55361,80230,5287,5293,5288,5286,5290,59339,54477,51763,5291,5305,5783,3636,65977,23533,5295,8394,57664,3631,3635,5296,8503	PLEKHA6,SYNJ2,PIP4K2C,PIK3R6,PLEKHA8,MTMR3,RAB14,INPP5J,INPP4B,ARF1,PIP5K1C,PLEKHA1,RAB5A,PIP5K1B,PIK3CG,RAB4A,MTMR14,SYNJ1,MTMR6,PIP4K2B,PI4K2B,PTEN,PI4K2A,RUFY1,PIK3C2B,PIK3CD,PIK3C2G,PIK3C2A,PIK3CA,PLEKHA2,PLEKHA5,INPP5K,PIK3CB,PIP4K2A,PTPN13,INPPL1,PLEKHA3,PIK3R5,PIK3R1,PIP5K1A,PLEKHA4,INPP4A,INPP5D,PIK3R2,PIK3R3
R-HSA-5602358	Diseases associated with the TLR signaling cascade	0.427543098711732	-0.849700179986924	24	22	0.00243524463139252	9034	10285	5970,7099,7100,51135,114609,1147,4790,3551,4792,7187,23643,4793,7096,10333,7098,81793,4791,948,7097,148022,4615,929	RELA,TLR4,TLR5,IRAK4,TIRAP,CHUK,NFKB1,IKBKB,NFKBIA,TRAF3,LY96,NFKBIB,TLR1,TLR6,TLR3,TLR10,NFKB2,CD36,TLR2,TICAM1,MYD88,CD14
R-HSA-5260271	Diseases of Immune System	0.427543098711732	-0.849700179986924	24	22	0.00243524463139252	9034	10285	4615,148022,7097,929,7096,4791,948,7098,81793,10333,7187,4790,4792,3551,4793,23643,7100,51135,5970,7099,1147,114609	MYD88,TICAM1,TLR2,CD14,TLR1,NFKB2,CD36,TLR3,TLR10,TLR6,TRAF3,NFKB1,NFKBIA,IKBKB,NFKBIB,LY96,TLR5,IRAK4,RELA,TLR4,CHUK,TIRAP
R-HSA-937041	IKK complex recruitment mediated by RIP1	0.427543098711732	-0.849700179986924	24	22	0.00243524463139252	9034	10285	7099,8737,7189,7322,353376,7335,11035,7311,7323,7098,1147,3551,148022,329,7316,330,6233,7314,7321,929,7334,23643	TLR4,RIPK1,TRAF6,UBE2D2,TICAM2,UBE2V1,RIPK3,UBA52,UBE2D3,TLR3,CHUK,IKBKB,TICAM1,BIRC2,UBC,BIRC3,RPS27A,UBB,UBE2D1,CD14,UBE2N,LY96
R-HSA-381070	IRE1alpha activates chaperones	0.43097293465756	-0.841709987468369	58	52	0.00575603276510959	9034	10285	2673,9570,5611,11231,7494,55062,11015,439,7709,10952,55176,5526,1663,2931,100137049,9820,4189,1639,84447,37,23480,10113,118,3309,9797,56005,9695,55033,4000,1200,2081,6464,2137,9114,27230,51726,29927,10897,10954,30827,3068,58477,22872,55738,10525,6734,7466,10130,116138,10106,7095,6745	GFPT1,GOSR2,DNAJC3,SEC63,XBP1,WIPI1,KDELR3,GET3,ZBTB17,SEC61B,SEC61A2,PPP2R5B,DDX11,GSK3A,PLA2G4B,CUL7,DNAJB9,DCTN1,SYVN1,ACADVL,SEC61G,PREB,ADD1,HSPA5,TATDN2,MYDGF,EDEM1,FKBP14,LMNA,TPP1,ERN1,SHC1,EXTL3,ATP6V0D1,SERP1,DNAJB11,SEC61A1,YIF1A,PDIA5,CXXC1,HDGF,SRPRB,SEC31A,ARFGAP1,HYOU1,SRPRA,WFS1,PDIA6,KLHDC3,CTDSP2,SEC62,SSR1
R-HSA-936837	Ion transport by P-type ATPases	0.43097293465756	-0.841709987468369	58	52	0.00575603276510959	9034	10285	57198,6588,5205,486,808,23200,23400,374868,488,496,10396,482,6717,27032,84239,805,9914,53828,5348,495,57205,5350,10079,53826,23250,23120,487,489,479,477,5349,57130,483,818,57194,148229,816,493,540,344905,478,817,815,51076,490,481,79895,476,51761,801,491,480	ATP8B2,SLN,ATP8B1,FXYD2,CALM3,ATP11B,ATP13A2,ATP9B,ATP2A2,ATP4B,ATP8A1,ATP1B2,SRI,ATP2C1,ATP13A4,CALM2,ATP2C2,FXYD4,FXYD1,ATP4A,ATP10D,PLN,ATP9A,FXYD6,ATP11A,ATP10B,ATP2A1,ATP2A3,ATP12A,ATP1A2,FXYD3,ATP13A1,ATP1B3,CAMK2G,ATP10A,ATP8B3,CAMK2B,ATP2B4,ATP7B,ATP13A5,ATP1A3,CAMK2D,CAMK2A,CUTC,ATP2B1,ATP1B1,ATP8B4,ATP1A1,ATP8A2,CALM1,ATP2B2,ATP1A4
R-HSA-5696400	Dual Incision in GG-NER	0.431122065739889	-0.841364013802479	41	37	0.00409563869825105	9034	10285	7316,9978,9557,8451,2968,6119,10038,7314,5982,57804,2965,54107,2967,1642,404672,1643,2071,51426,7311,5983,2067,5985,2072,6118,10714,5427,2073,5111,7507,6233,5981,56655,5424,142,6117,2068,5984	UBC,RBX1,CHD1L,CUL4A,GTF2H4,RPA3,PARP2,UBB,RFC2,POLD4,GTF2H1,POLE3,GTF2H3,DDB1,GTF2H5,DDB2,ERCC3,POLK,UBA52,RFC3,ERCC1,RFC5,ERCC4,RPA2,POLD3,POLE2,ERCC5,PCNA,XPA,RPS27A,RFC1,POLE4,POLD1,PARP1,RPA1,ERCC2,RFC4
R-HSA-442755	Activation of NMDA receptor upon glutamate binding and postsynaptic events	0.431122065739889	-0.841364013802479	41	37	0.00409563869825105	9034	10285	5594,801,88,5170,2890,2893,5894,84254,815,817,805,6237,114,1742,2903,5923,1385,2905,10142,816,109,107,5567,6195,814,4747,673,818,808,5568,2906,2904,2891,3265,5566,6196,5924	MAPK1,CALM1,ACTN2,PDPK1,GRIA1,GRIA4,RAF1,CAMKK1,CAMK2A,CAMK2D,CALM2,RRAS,ADCY8,DLG4,GRIN2A,RASGRF1,CREB1,GRIN2C,AKAP9,CAMK2B,ADCY3,ADCY1,PRKACB,RPS6KA1,CAMK4,NEFL,BRAF,CAMK2G,CALM3,PRKACG,GRIN2D,GRIN2B,GRIA2,HRAS,PRKACA,RPS6KA2,RASGRF2
R-HSA-983712	Ion channel transport	0.431802036057623	-0.839788045633199	209	185	0.0204781934912553	9034	10285	540,10110,533,483,26133,1179,57130,9311,479,2555,7439,491,11059,801,65268,476,5894,10312,41,7809,815,140803,2040,50636,8989,6337,6717,6340,245972,496,374868,55283,200909,2281,2569,6446,1188,255231,2741,5350,2743,54795,7223,51606,84239,535,23545,526,57719,285242,245973,818,196527,155066,8992,2560,5349,144453,6338,56302,65125,2567,51761,529,490,51076,53373,219931,817,7222,57101,2554,57192,1187,488,6233,200959,23327,7225,6339,94015,338440,23200,54822,54831,7226,59341,487,10079,28962,23678,1180,5348,53828,285175,57578,148229,57194,150159,6263,9177,8001,51382,477,2557,480,2561,79895,65266,525,478,127124,63982,6261,259232,482,57113,80036,162514,523,444,9629,10396,808,57348,9550,6588,5205,23120,10345,7316,55107,51802,121601,27032,9114,816,22802,493,2558,170572,51393,203859,50617,528,90423,55515,285335,7314,2570,1182,481,4308,2566,344905,6262,23400,7442,80727,1186,29850,486,3359,10786,55129,2562,284525,57198,55503,53826,23250,9635,161003,100847046,489,133308,2559,495,40,57205,805,9914,7311,7220,79054	ATP7B,SGK2,ATP6V0B,ATP1B3,TRPC4AP,CLCA1,ATP13A1,ASIC3,ATP12A,GABRA2,BEST1,ATP2B2,WWP1,CALM1,WNK2,ATP1A1,RAF1,TCIRG1,ASIC1,BSND,CAMK2A,TRPM6,STOM,ANO7,TRPA1,SCNN1A,SRI,SCNN1G,ATP6V0D2,ATP4B,ATP9B,MCOLN3,HTR3D,FKBP1B,GABRR1,SGK1,CLCNKB,MCOLN2,GLRA1,PLN,GLRB,TRPM4,TRPC4,ATP6V1H,ATP13A4,ATP6V0A1,ATP6V0A2,ATP6V1B2,ANO8,HTR3E,ATP6V1C2,CAMK2G,ANO6,ATP6V0E2,ATP6V0E1,GABRB1,FXYD3,BEST3,SCNN1B,TRPV5,WNK1,GABRG3,ATP8A2,ATP6V1E1,ATP2B1,CUTC,TPCN1,TPCN2,CAMK2D,TRPC3,ANO2,GABRA1,MCOLN1,CLCNKA,ATP2A2,RPS27A,GABRR3,NEDD4L,TRPC6,SCNN1D,TTYH2,ANO9,ATP11B,TRPM7,BEST2,TRPM2,TRPV4,ATP2A1,ATP9A,OSTM1,SGK3,CLCN1,FXYD1,FXYD4,UNC80,UNC79,ATP8B3,ATP10A,SLC9B1,RYR3,HTR3B,GLRA3,ATP6V1D,ATP1A2,GABRA4,ATP1A4,GABRB2,ATP8B4,WNK4,ATP6V1B1,ATP1A3,ATP6V1G3,ANO3,RYR1,NALCN,ATP1B2,TRPC7,TRPM3,TRPV3,ATP6V1A,ASPH,CLCA3P,ATP8A1,CALM3,TTYH1,ATP6V1G1,SLN,ATP8B1,ATP10B,TRDN,UBC,ANO1,ASIC5,ANO4,ATP2C1,ATP6V0D1,CAMK2B,CLCA4,ATP2B4,GABRA5,HTR3C,TRPV2,ANO5,ATP6V0A4,ATP6V1C1,ATP6V1E2,ASIC4,SLC9C1,UBB,GABRR2,CLCN3,ATP1B1,TRPM1,GABRG2,ATP13A5,RYR2,ATP13A2,TRPV1,TTYH3,CLCN7,TRPM5,FXYD2,HTR3A,SLC17A3,ANO10,GABRB3,SLC9C2,ATP8B2,TRPV6,FXYD6,ATP11A,CLCA2,STOML3,MIR5010,ATP2A3,SLC9B2,GABRA6,ATP4A,ASIC2,ATP10D,CALM2,ATP2C2,UBA52,TRPC1,TRPM8
R-HSA-211935	Fatty acids	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	1549,8529,284541,11283,126410,66002,1555,1573,1553,1580,1565,57834,1579,1572	CYP2A7,CYP4F2,CYP4A22,CYP4F8,CYP4F22,CYP4F12,CYP2B6,CYP2J2,CYP2A13,CYP4B1,CYP2D6,CYP4F11,CYP4A11,CYP2F1
R-HSA-5358749	S37 mutants of beta-catenin aren't phosphorylated	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	5518,5527,5519,8312,5516,5525,324,2932,5528,5529,5515,5526,1499,1452	PPP2R1A,PPP2R5C,PPP2R1B,AXIN1,PPP2CB,PPP2R5A,APC,GSK3B,PPP2R5D,PPP2R5E,PPP2CA,PPP2R5B,CTNNB1,CSNK1A1
R-HSA-3322077	Glycogen synthesis	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	2997,7316,7360,378884,2632,7314,6233,2992,7957,5507,55276,5236,2998,7311	GYS1,UBC,UGP2,NHLRC1,GBE1,UBB,RPS27A,GYG1,EPM2A,PPP1R3C,PGM2,PGM1,GYS2,UBA52
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	6457,6455,2060,2885,7311,8027,9146,6456,7316,4233,10254,867,6233,7314	SH3GL3,SH3GL1,EPS15,GRB2,UBA52,STAM,HGS,SH3GL2,UBC,MET,STAM2,CBL,RPS27A,UBB
R-HSA-4839743	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	5527,5516,5525,5519,8312,324,5518,5529,5526,5515,1499,1452,2932,5528	PPP2R5C,PPP2CB,PPP2R5A,PPP2R1B,AXIN1,APC,PPP2R1A,PPP2R5E,PPP2R5B,PPP2CA,CTNNB1,CSNK1A1,GSK3B,PPP2R5D
R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	6916,873,1582,80142,145482,127281,27306,5743,3248,5742,9536,5740,8644,10728	TBXAS1,CBR1,CYP8B1,PTGES2,PTGR2,PRXL2B,HPGDS,PTGS2,HPGD,PTGS1,PTGES,PTGIS,AKR1C3,PTGES3
R-HSA-5358751	S45 mutants of beta-catenin aren't phosphorylated	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	5527,8312,5519,5525,5516,324,5518,5526,5515,5529,1499,1452,2932,5528	PPP2R5C,AXIN1,PPP2R1B,PPP2R5A,PPP2CB,APC,PPP2R1A,PPP2R5B,PPP2CA,PPP2R5E,CTNNB1,CSNK1A1,GSK3B,PPP2R5D
R-HSA-205043	NRIF signals cell death from the nucleus	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	8878,5664,7316,6233,7314,51107,5599,23385,23421,4803,4804,7189,7311,83464	SQSTM1,PSEN2,UBC,RPS27A,UBB,APH1A,MAPK8,NCSTN,ITGB3BP,NGF,NGFR,TRAF6,UBA52,APH1B
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	6737,7316,3661,81844,340061,6233,7314,29110,81030,22954,23220,11277,147945,7311	TRIM21,UBC,IRF3,TRIM56,STING1,RPS27A,UBB,TBK1,ZBP1,TRIM32,DTX4,TREX1,NLRP4,UBA52
R-HSA-5358752	T41 mutants of beta-catenin aren't phosphorylated	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	5527,5525,5519,5516,8312,324,5518,5515,5526,5529,1499,1452,2932,5528	PPP2R5C,PPP2R5A,PPP2R1B,PPP2CB,AXIN1,APC,PPP2R1A,PPP2CA,PPP2R5B,PPP2R5E,CTNNB1,CSNK1A1,GSK3B,PPP2R5D
R-HSA-5339716	Misspliced GSK3beta mutants stabilize beta-catenin	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	1452,1499,5526,5529,5515,5528,2932,324,5519,5525,8312,5516,5527,5518	CSNK1A1,CTNNB1,PPP2R5B,PPP2R5E,PPP2CA,PPP2R5D,GSK3B,APC,PPP2R1B,PPP2R5A,AXIN1,PPP2CB,PPP2R5C,PPP2R1A
R-HSA-5358747	S33 mutants of beta-catenin aren't phosphorylated	0.439669287525559	-0.821732453937297	15	14	0.00154970112906797	9034	10285	1452,1499,5529,5526,5515,5528,2932,324,5525,5519,5516,8312,5527,5518	CSNK1A1,CTNNB1,PPP2R5E,PPP2R5B,PPP2CA,PPP2R5D,GSK3B,APC,PPP2R5A,PPP2R1B,PPP2CB,AXIN1,PPP2R5C,PPP2R1A
R-HSA-71406	Pyruvate metabolism and Citric Acid (TCA) cycle	0.441635586560822	-0.817270201756983	49	44	0.00487048926278503	9034	10285	8803,137872,23539,1737,3420,25874,3939,6256,9123,1738,5163,6389,4191,3945,8801,3948,57546,5166,92483,6392,3419,6566,51660,6391,50,55066,8802,3418,5162,5467,682,160287,1431,79944,4967,2739,8050,54704,2271,3029,1743,6390,23530,5164	SUCLA2,ADHFE1,SLC16A8,DLAT,IDH3B,MPC2,LDHA,RXRA,SLC16A3,DLD,PDK1,SDHA,MDH2,LDHB,SUCLG2,LDHC,PDP2,PDK4,LDHAL6B,SDHD,IDH3A,SLC16A1,MPC1,SDHC,ACO2,PDPR,SUCLG1,IDH2,PDHB,PPARD,BSG,LDHAL6A,CS,L2HGDH,OGDH,GLO1,PDHX,PDP1,FH,HAGH,DLST,SDHB,NNT,PDK2
R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	0.442879062874794	-0.81445854197509	32	29	0.0032100951959265	9034	10285	8312,5516,324,5518,8321,5529,5515,7479,2535,1452,1499,4040,5525,5519,5527,857,4041,1455,1856,7471,5526,1855,7478,2932,7855,1857,10023,89780,5528	AXIN1,PPP2CB,APC,PPP2R1A,FZD1,PPP2R5E,PPP2CA,WNT8B,FZD2,CSNK1A1,CTNNB1,LRP6,PPP2R5A,PPP2R1B,PPP2R5C,CAV1,LRP5,CSNK1G2,DVL2,WNT1,PPP2R5B,DVL1,WNT8A,GSK3B,FZD5,DVL3,FRAT1,WNT3A,PPP2R5D
R-HSA-69190	DNA strand elongation	0.442879062874794	-0.81445854197509	32	29	0.0032100951959265	9034	10285	84296,5424,8318,4173,4172,5984,23649,9837,6117,64785,6118,10714,84515,5985,2237,5111,5981,3978,1763,5982,57804,4174,5983,5557,51659,5558,4171,4175,6119	GINS4,POLD1,CDC45,MCM4,MCM3,RFC4,POLA2,GINS1,RPA1,GINS3,RPA2,POLD3,MCM8,RFC5,FEN1,PCNA,RFC1,LIG1,DNA2,RFC2,POLD4,MCM5,RFC3,PRIM1,GINS2,PRIM2,MCM2,MCM6,RPA3
R-HSA-975138	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.44288337015126	-0.814448816395621	91	81	0.00896612796103609	9034	10285	5518,10454,7867,7189,8767,6416,246330,9261,5609,5602,7098,5516,4791,8454,6288,51231,5594,148022,57162,1848,466,7314,929,1846,64127,79155,4214,5515,51295,51135,1386,5604,6500,1326,1432,6196,6283,23118,1385,3551,4790,2353,7334,5599,4793,6195,9252,351,353376,7311,5600,1660,5595,4208,5598,4205,57161,4615,7316,3656,54106,8945,7099,5970,177,7335,5608,5606,5519,3725,1147,4792,5528,5601,6233,23643,3146,10392,1849,23291,6885	PPP2R1A,TAB1,MAPKAPK3,TRAF6,RIPK2,MAP2K4,PELI3,MAPKAPK2,MAP2K7,MAPK10,TLR3,PPP2CB,NFKB2,CUL1,SAA1,VRK3,MAPK1,TICAM1,PELI1,DUSP6,ATF1,UBB,CD14,DUSP4,NOD2,TNIP2,MAP3K1,PPP2CA,ECSIT,IRAK4,ATF2,MAP2K1,SKP1,MAP3K8,MAPK14,RPS6KA2,S100A12,TAB2,CREB1,IKBKB,NFKB1,FOS,UBE2N,MAPK8,NFKBIB,RPS6KA1,RPS6KA5,APP,TICAM2,UBA52,MAPK11,DHX9,MAPK3,MEF2C,MAPK7,MEF2A,PELI2,MYD88,UBC,IRAK2,TLR9,BTRC,TLR4,RELA,AGER,UBE2V1,MAP2K6,MAP2K3,PPP2R1B,JUN,CHUK,NFKBIA,PPP2R5D,MAPK9,RPS27A,LY96,HMGB1,NOD1,DUSP7,FBXW11,MAP3K7
R-HSA-3371571	HSF1-dependent transactivation	0.457465001526138	-0.78205489658921	23	21	0.00232455169360195	9034	10285	818,57521,3337,815,3326,3320,64223,3306,817,2033,3304,100302237,10728,84335,3281,816,2288,1387,3305,3312,2475	CAMK2G,RPTOR,DNAJB1,CAMK2A,HSP90AB1,HSP90AA1,MLST8,HSPA2,CAMK2D,EP300,HSPA1B,MIR1281,PTGES3,AKT1S1,HSBP1,CAMK2B,FKBP4,CREBBP,HSPA1L,HSPA8,MTOR
R-HSA-8863678	Neurodegenerative Diseases	0.457465001526138	-0.78205489658921	23	21	0.00232455169360195	9034	10285	84290,824,4001,5052,993,831,2309,823,994,7001,356,6648,8851,1020,7531,351,995,2801,4000,10018,3725	CAPNS2,CAPN2,LMNB1,PRDX1,CDC25A,CAST,FOXO3,CAPN1,CDC25B,PRDX2,FASLG,SOD2,CDK5R1,CDK5,YWHAE,APP,CDC25C,GOLGA2,LMNA,BCL2L11,JUN
R-HSA-400508	Incretin synthesis, secretion, and inactivation	0.457465001526138	-0.78205489658921	23	21	0.00232455169360195	9034	10285	2626,23478,2641,1045,2864,1803,338557,6934,2922,90701,2784,2695,60559,346562,51764,1499,3670,9789,5122,5080,3952	GATA4,SEC11A,GCG,CDX2,FFAR1,DPP4,FFAR4,TCF7L2,GRP,SEC11C,GNB3,GIP,SPCS3,GNAT3,GNG13,CTNNB1,ISL1,SPCS2,PCSK1,PAX6,LEP
R-HSA-8862803	Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	0.457465001526138	-0.78205489658921	23	21	0.00232455169360195	9034	10285	84290,831,2309,993,5052,4001,824,994,823,7001,1020,8851,6648,356,351,995,7531,10018,4000,2801,3725	CAPNS2,CAST,FOXO3,CDC25A,PRDX1,LMNB1,CAPN2,CDC25B,CAPN1,PRDX2,CDK5,CDK5R1,SOD2,FASLG,APP,CDC25C,YWHAE,BCL2L11,LMNA,GOLGA2,JUN
R-HSA-5620922	BBSome-mediated cargo-targeting to cilium	0.457465001526138	-0.78205489658921	23	21	0.00232455169360195	9034	10285	22948,84100,27241,79738,585,8195,582,55212,54585,129880,10576,6608,166379,123016,10694,117177,92482,2847,6753,583,10575	CCT5,ARL6,BBS9,BBS10,BBS4,MKKS,BBS1,BBS7,LZTFL1,BBS5,CCT2,SMO,BBS12,TTC8,CCT8,RAB3IP,BBIP1,MCHR1,SSTR3,BBS2,CCT4
R-HSA-8855121	VLDL interactions	0.457465001526138	-0.78205489658921	23	21	0.00232455169360195	9034	10285	5034,7436,10062,55911,29116,255738,1173,4547,1211,7376,160,2534,338,1600,1175,341,51599,1213,161,163,5649	P4HB,VLDLR,NR1H3,APOBR,MYLIP,PCSK9,AP2M1,MTTP,CLTA,NR1H2,AP2A1,FYN,APOB,DAB1,AP2S1,APOC1,LSR,CLTC,AP2A2,AP2B1,RELN
R-HSA-5627123	RHO GTPases activate PAKs	0.457465001526138	-0.78205489658921	23	21	0.00232455169360195	9034	10285	5062,4660,805,998,4627,10398,808,4638,4771,801,2017,5879,4659,79784,4637,4629,4628,3984,103910,5058,5500	PAK2,PPP1R12B,CALM2,CDC42,MYH9,MYL9,CALM3,MYLK,NF2,CALM1,CTTN,RAC1,PPP1R12A,MYH14,MYL6,MYH11,MYH10,LIMK1,MYL12B,PAK1,PPP1CB
R-HSA-193670	p75NTR negatively regulates cell cycle via SC1	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	8841,11108,3065,4804,4803,3066	HDAC3,PRDM4,HDAC1,NGFR,NGF,HDAC2
R-HSA-8849470	PTK6 Regulates Cell Cycle	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	1019,898,5753,1017,1027,595	CDK4,CCNE1,PTK6,CDK2,CDKN1B,CCND1
R-HSA-193993	Mineralocorticoid biosynthesis	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	3284,3283,3972,1585,1589,1081	HSD3B2,HSD3B1,LHB,CYP11B2,CYP21A2,CGA
R-HSA-187015	Activation of TRKA receptors	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	135,116,4915,117,4914,4803	ADORA2A,ADCYAP1,NTRK2,ADCYAP1R1,NTRK1,NGF
R-HSA-173623	Classical antibody-mediated complement activation	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	715,712,713,716,1401,714	C1R,C1QA,C1QB,C1S,CRP,C1QC
R-HSA-2142770	Synthesis of 15-eicosatetraenoic acid derivatives	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	5743,247,2877,2876,2879,246	PTGS2,ALOX15B,GPX2,GPX1,GPX4,ALOX15
R-HSA-2142712	Synthesis of 12-eicosatetraenoic acid derivatives	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	2876,2879,2877,239,246,242	GPX1,GPX4,GPX2,ALOX12,ALOX15,ALOX12B
R-HSA-3065679	SUMO is proteolytically processed	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	7341,6613,6612,205564,59343,29843	SUMO1,SUMO2,SUMO3,SENP5,SENP2,SENP1
R-HSA-5660668	CLEC7A/inflammasome pathway	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	4790,5970,29108,3553,10892,841	NFKB1,RELA,PYCARD,IL1B,MALT1,CASP8
R-HSA-6799990	Metal sequestration by antimicrobial proteins	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	6279,3934,6280,4057,6278,338324	S100A8,LCN2,S100A9,LTF,S100A7,S100A7A
R-HSA-5676934	Protein repair	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	7295,51734,4482,5110,253827,22921	TXN,MSRB1,MSRA,PCMT1,MSRB3,MSRB2
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	2230,2232,112812,1583,5443,4158	FDX1,FDXR,FDX2,CYP11A1,POMC,MC2R
R-HSA-190370	FGFR1b ligand binding and activation	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	2247,2246,2260,2248,2255,27006	FGF2,FGF1,FGFR1,FGF3,FGF10,FGF22
R-HSA-6793080	rRNA modification in the mitochondrion	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	387338,55178,79922,51106,130916,29960	NSUN4,MRM3,MRM1,TFB1M,MTERF4,MRM2
R-HSA-5339717	Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	79412,83999,27123,4041,27121,22943	KREMEN2,KREMEN1,DKK2,LRP5,DKK4,DKK1
R-HSA-500753	Pyrimidine biosynthesis	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	7372,7298,1723,790,1635,1854	UMPS,TYMS,DHODH,CAD,DCTD,DUT
R-HSA-68616	Assembly of the ORC complex at the origin of replication	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	5000,4998,4999,23595,5001,23594	ORC4,ORC1,ORC2,ORC3,ORC5,ORC6
R-HSA-8851907	MET activates PI3K/AKT signaling	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	2885,3082,2549,5295,4233,5290	GRB2,HGF,GAB1,PIK3R1,MET,PIK3CA
R-HSA-2142700	Synthesis of Lipoxins (LX)	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	4056,239,3248,241,240,22949	LTC4S,ALOX12,HPGD,ALOX5AP,ALOX5,PTGR1
R-HSA-177135	Conjugation of benzoate with glycine	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	92292,116285,10249,348158,219970,389396	GLYATL1,ACSM1,GLYAT,ACSM2B,GLYATL2,GLYATL3
R-HSA-442717	CREB phosphorylation through the activation of CaMKK	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	805,1385,801,808,84254,814	CALM2,CREB1,CALM1,CALM3,CAMKK1,CAMK4
R-HSA-5626978	TNFR1-mediated ceramide production	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	55512,7124,7132,10399,8439,6610	SMPD3,TNF,TNFRSF1A,RACK1,NSMAF,SMPD2
R-HSA-6798163	Choline catabolism	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	501,1757,23446,55349,29958,635	ALDH7A1,SARDH,SLC44A1,CHDH,DMGDH,BHMT
R-HSA-446199	Synthesis of Dolichyl-phosphate	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	79947,57171,4597,79644,116150,22845	DHDDS,DOLPP1,MVD,SRD5A3,NUS1,DOLK
R-HSA-193144	Estrogen biosynthesis	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	51171,3292,51170,3294,1588,441282	HSD17B14,HSD17B1,HSD17B11,HSD17B2,CYP19A1,AKR1B15
R-HSA-5693548	Sensing of DNA Double Strand Breaks	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	10111,4361,3838,10524,4683,472	RAD50,MRE11,KPNA2,KAT5,NBN,ATM
R-HSA-3000484	Scavenging by Class F Receptors	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	338,8578,3320,10808,10525,811	APOB,SCARF1,HSP90AA1,HSPH1,HYOU1,CALR
R-HSA-1237112	Methionine salvage pathway	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	51074,58478,55256,4507,84245,2805	APIP,ENOPH1,ADI1,MTAP,MRI1,GOT1
R-HSA-5674499	Negative feedback regulation of MAPK pathway	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	673,5894,5595,5605,5604,5594	BRAF,RAF1,MAPK3,MAP2K2,MAP2K1,MAPK1
R-HSA-111957	Cam-PDE 1 activation	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	805,5153,801,808,5136,5137	CALM2,PDE1B,CALM1,CALM3,PDE1A,PDE1C
R-HSA-77288	mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	34,1666,3030,3032,1632,33	ACADM,DECR1,HADHA,HADHB,ECI1,ACADL
R-HSA-3304356	SMAD2/3 Phosphorylation Motif Mutants in Cancer	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	4088,7048,7046,7040,4087,9372	SMAD3,TGFBR2,TGFBR1,TGFB1,SMAD2,ZFYVE9
R-HSA-8857538	PTK6 promotes HIF1A stabilization	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	1956,1839,3091,120892,10457,5753	EGFR,HBEGF,HIF1A,LRRK2,GPNMB,PTK6
R-HSA-176417	Phosphorylation of Emi1	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	5347,51343,991,26271,983,891	PLK1,FZR1,CDC20,FBXO5,CDK1,CCNB1
R-HSA-6806942	MET Receptor Activation	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	3082,10653,6692,3249,3083,4233	HGF,SPINT2,SPINT1,HPN,HGFAC,MET
R-HSA-5336415	Uptake and function of diphtheria toxin	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	3320,3326,1839,1938,7296,928	HSP90AA1,HSP90AB1,HBEGF,EEF2,TXNRD1,CD9
R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	0.459163119565351	-0.778349751737551	6	6	0.000664157626743414	9034	10285	1499,100302237,9208,2033,3661,1387	CTNNB1,MIR1281,LRRFIP1,EP300,IRF3,CREBBP
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	0.462673394535662	-0.770733885185632	48	43	0.00475979632499447	9034	10285	1540,114548,3551,7334,29108,10628,3326,83737,23118,1432,841,64127,7189,8767,10454,6300,329,9051,4210,6885,9447,330,10392,834,5608,7335,7128,10910,1147,22861,24145,598,842,7295,3656,837,5603,5027,351,835,596,58484,5600	CYLD,NLRP3,IKBKB,UBE2N,PYCARD,TXNIP,HSP90AB1,ITCH,TAB2,MAPK14,CASP8,NOD2,TRAF6,RIPK2,TAB1,MAPK12,BIRC2,PSTPIP1,MEFV,MAP3K7,AIM2,BIRC3,NOD1,CASP1,MAP2K6,UBE2V1,TNFAIP3,SUGT1,CHUK,NLRP1,PANX1,BCL2L1,CASP9,TXN,IRAK2,CASP4,MAPK13,P2RX7,APP,CASP2,BCL2,NLRC4,MAPK11
R-HSA-5654733	Negative regulation of FGFR4 signaling	0.468973883260838	-0.757208198097388	31	28	0.00309940225813593	9034	10285	2254,7316,5781,5594,8817,8822,867,5515,7314,2251,2249,2885,5518,5516,10818,5595,7311,26281,8074,2253,2247,673,6233,9965,10253,2246,2264,6714	FGF9,UBC,PTPN11,MAPK1,FGF18,FGF17,CBL,PPP2CA,UBB,FGF6,FGF4,GRB2,PPP2R1A,PPP2CB,FRS2,MAPK3,UBA52,FGF20,FGF23,FGF8,FGF2,BRAF,RPS27A,FGF19,SPRY2,FGF1,FGFR4,SRC
R-HSA-418360	Platelet calcium homeostasis	0.468973883260838	-0.757208198097388	31	28	0.00309940225813593	9034	10285	805,5025,490,5027,7222,80228,100616453,3708,801,6786,489,491,84876,487,5026,6543,5024,808,6547,3710,488,6717,493,57113,6546,7225,5023,3709	CALM2,P2RX4,ATP2B1,P2RX7,TRPC3,ORAI2,MIR4687,ITPR1,CALM1,STIM1,ATP2A3,ATP2B2,ORAI1,ATP2A1,P2RX5,SLC8A2,P2RX3,CALM3,SLC8A3,ITPR3,ATP2A2,SRI,ATP2B4,TRPC7,SLC8A1,TRPC6,P2RX1,ITPR2
R-HSA-352230	Amino acid transport across the plasma membrane	0.468973883260838	-0.757208198097388	31	28	0.00309940225813593	9034	10285	6542,124935,6533,11136,56301,55089,206358,6539,117247,81539,10991,8501,23657,340024,6520,9057,23428,54716,6510,6519,9056,348932,153201,55117,54407,8140,6509,6541	SLC7A2,SLC43A2,SLC6A6,SLC7A9,SLC7A10,SLC38A4,SLC36A1,SLC6A12,SLC16A10,SLC38A1,SLC38A3,SLC43A1,SLC7A11,SLC6A19,SLC3A2,SLC7A6,SLC7A8,SLC6A20,SLC1A5,SLC3A1,SLC7A7,SLC6A18,SLC36A2,SLC6A15,SLC38A2,SLC7A5,SLC1A4,SLC7A1
R-HSA-114452	Activation of BH3-only proteins	0.468973883260838	-0.757208198097388	31	28	0.00309940225813593	9034	10285	5533,7029,2810,5366,8626,7531,90427,208,596,27113,7157,23368,10000,7534,7159,5534,140735,7529,10018,7161,207,1869,7027,8655,7533,10971,7532,5599	PPP3CC,TFDP2,SFN,PMAIP1,TP63,YWHAE,BMF,AKT2,BCL2,BBC3,TP53,PPP1R13B,AKT3,YWHAZ,TP53BP2,PPP3R1,DYNLL2,YWHAB,BCL2L11,TP73,AKT1,E2F1,TFDP1,DYNLL1,YWHAH,YWHAQ,YWHAG,MAPK8
R-HSA-6804758	Regulation of TP53 Activity through Acetylation	0.468973883260838	-0.757208198097388	31	28	0.00309940225813593	9034	10285	79837,57459,1108,208,100302237,2033,1107,7157,5300,10000,9219,29117,64769,3622,54815,3065,5305,27154,5608,23774,207,5371,5928,3066,53615,7862,7994,8396	PIP4K2C,GATAD2B,CHD4,AKT2,MIR1281,EP300,CHD3,TP53,PIN1,AKT3,MTA2,BRD7,MEAF6,ING2,GATAD2A,HDAC1,PIP4K2A,BRPF3,MAP2K6,BRD1,AKT1,PML,RBBP4,HDAC2,MBD3,BRPF1,KAT6A,PIP4K2B
R-HSA-450282	MAPK targets/ Nuclear events mediated by MAP kinases	0.468973883260838	-0.757208198097388	31	28	0.00309940225813593	9034	10285	9261,5600,5602,5516,5595,4208,5518,9252,466,1846,5515,5598,4205,5594,51231,1848,1432,6196,5519,3725,1386,2353,1849,5599,6195,1385,5528,5601	MAPKAPK2,MAPK11,MAPK10,PPP2CB,MAPK3,MEF2C,PPP2R1A,RPS6KA5,ATF1,DUSP4,PPP2CA,MAPK7,MEF2A,MAPK1,VRK3,DUSP6,MAPK14,RPS6KA2,PPP2R1B,JUN,ATF2,FOS,DUSP7,MAPK8,RPS6KA1,CREB1,PPP2R5D,MAPK9
R-HSA-70326	Glucose metabolism	0.469090259519976	-0.756960078050096	81	72	0.00796989152092097	9034	10285	805,2992,6576,178,7311,5236,5210,5224,7316,226,2632,26330,8402,2645,229,132789,7167,2805,3099,5105,5568,8789,808,5091,5566,5519,5834,5211,5528,5208,2806,5567,6233,83440,1468,5518,3098,669,2548,2821,5313,5507,55276,5516,7360,801,5261,4191,3101,7314,5515,10007,2023,5209,5214,5836,2027,7957,4190,8604,2597,2998,5257,5232,5315,378884,5837,2026,5223,2203,2997,10165	CALM2,GYG1,SLC25A1,AGL,UBA52,PGM1,PFKFB4,PGAM2,UBC,ALDOA,GBE1,GAPDHS,SLC25A11,GCK,ALDOB,GNPDA2,TPI1,GOT1,HK2,PCK1,PRKACG,FBP2,CALM3,PC,PRKACA,PPP2R1B,PYGB,PFKL,PPP2R5D,PFKFB2,GOT2,PRKACB,RPS27A,ADPGK,SLC25A10,PPP2R1A,HK1,BPGM,GAA,GPI,PKLR,PPP1R3C,PGM2,PPP2CB,UGP2,CALM1,PHKG2,MDH2,HK3,UBB,PPP2CA,GNPDA1,ENO1,PFKFB3,PFKP,PYGL,ENO3,EPM2A,MDH1,SLC25A12,GAPDH,GYS2,PHKB,PGK2,PKM,NHLRC1,PYGM,ENO2,PGAM1,FBP1,GYS1,SLC25A13
R-HSA-381038	XBP1(S) activates chaperone genes	0.469777078937905	-0.755496996926036	56	50	0.00553464688952845	9034	10285	118,10113,23480,37,1639,9820,4189,84447,2931,100137049,1663,5526,55176,7709,10952,7494,439,11015,55062,5611,11231,2673,9570,6745,10106,7095,7466,10130,116138,10525,6734,22872,55738,58477,10954,30827,3068,29927,10897,9114,27230,51726,2137,6464,4000,1200,55033,9695,9797,56005	ADD1,PREB,SEC61G,ACADVL,DCTN1,CUL7,DNAJB9,SYVN1,GSK3A,PLA2G4B,DDX11,PPP2R5B,SEC61A2,ZBTB17,SEC61B,XBP1,GET3,KDELR3,WIPI1,DNAJC3,SEC63,GFPT1,GOSR2,SSR1,CTDSP2,SEC62,WFS1,PDIA6,KLHDC3,HYOU1,SRPRA,SEC31A,ARFGAP1,SRPRB,PDIA5,CXXC1,HDGF,SEC61A1,YIF1A,ATP6V0D1,SERP1,DNAJB11,EXTL3,SHC1,LMNA,TPP1,FKBP14,EDEM1,TATDN2,MYDGF
R-HSA-450294	MAP kinase activation in TLR cascade	0.475791997411236	-0.742774500482897	64	57	0.00630949745406243	9034	10285	51231,5594,1848,7314,466,64127,1846,79155,5515,5518,7867,10454,7189,8767,6416,9261,5602,5609,5516,8454,4790,1385,3551,2353,7334,5599,6195,1386,6500,5604,1326,1432,6196,23118,4205,5598,7316,3656,9252,7311,5600,4208,5595,5528,5601,6233,1849,10392,6885,23291,8945,5608,7335,5606,5519,1147,3725	VRK3,MAPK1,DUSP6,UBB,ATF1,NOD2,DUSP4,TNIP2,PPP2CA,PPP2R1A,MAPKAPK3,TAB1,TRAF6,RIPK2,MAP2K4,MAPKAPK2,MAPK10,MAP2K7,PPP2CB,CUL1,NFKB1,CREB1,IKBKB,FOS,UBE2N,MAPK8,RPS6KA1,ATF2,SKP1,MAP2K1,MAP3K8,MAPK14,RPS6KA2,TAB2,MEF2A,MAPK7,UBC,IRAK2,RPS6KA5,UBA52,MAPK11,MEF2C,MAPK3,PPP2R5D,MAPK9,RPS27A,DUSP7,NOD1,MAP3K7,FBXW11,BTRC,MAP2K6,UBE2V1,MAP2K3,PPP2R1B,CHUK,JUN
R-HSA-420499	Class C/3 (Metabotropic glutamate/pheromone receptors)	0.477435134925133	-0.739326971377587	39	35	0.00387425282266991	9034	10285	50837,259295,50838,259289,846,83756,5726,50834,259296,54429,50835,50831,50832,2912,2550,80835,2913,80834,222545,259292,259286,2915,2917,259294,50833,2911,259287,2916,259285,2914,9568,259290,338398,2918,50839	TAS2R7,TAS2R20,TAS2R13,TAS2R43,CASR,TAS1R3,TAS2R38,TAS2R1,TAS2R50,TAS2R5,TAS2R9,TAS2R3,TAS2R4,GRM2,GABBR1,TAS1R1,GRM3,TAS1R2,GPRC6A,TAS2R46,TAS2R40,GRM5,GRM7,TAS2R19,TAS2R16,GRM1,TAS2R41,GRM6,TAS2R39,GRM4,GABBR2,TAS2R31,TAS2R60,GRM8,TAS2R10
R-HSA-174403	Glutathione synthesis and recycling	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	124975,91227,79017,2687,494143,2730,79094,2678,55748,2937,2686,2729,2679	GGT6,GGTLC2,GGCT,GGT5,CHAC2,GCLM,CHAC1,GGT1,CNDP2,GSS,GGT7,GCLC,GGT3P
R-HSA-4839744	truncated APC mutants destabilize the destruction complex	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	5518,8312,5525,5516,5519,5527,324,2932,5528,5526,5515,5529,1452	PPP2R1A,AXIN1,PPP2R5A,PPP2CB,PPP2R1B,PPP2R5C,APC,GSK3B,PPP2R5D,PPP2R5B,PPP2CA,PPP2R5E,CSNK1A1
R-HSA-5467337	APC truncation mutants have impaired AXIN binding	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	5515,5526,5529,1452,2932,5528,5525,5516,5519,8312,5527,324,5518	PPP2CA,PPP2R5B,PPP2R5E,CSNK1A1,GSK3B,PPP2R5D,PPP2R5A,PPP2CB,PPP2R1B,AXIN1,PPP2R5C,APC,PPP2R1A
R-HSA-5467348	Truncations of AMER1 destabilize the destruction complex	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	324,5519,8312,5516,5525,5527,5518,1452,5515,5526,5529,5528,2932	APC,PPP2R1B,AXIN1,PPP2CB,PPP2R5A,PPP2R5C,PPP2R1A,CSNK1A1,PPP2CA,PPP2R5B,PPP2R5E,PPP2R5D,GSK3B
R-HSA-418359	Reduction of cytosolic Ca++ levels	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	6546,801,488,487,6717,489,491,493,6543,6547,805,490,808	SLC8A1,CALM1,ATP2A2,ATP2A1,SRI,ATP2A3,ATP2B2,ATP2B4,SLC8A2,SLC8A3,CALM2,ATP2B1,CALM3
R-HSA-419408	Lysosphingolipid and LPA receptors	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	9890,9294,64748,79948,8698,1901,54886,163404,1903,53637,1902,57121,23566	PLPPR4,S1PR2,PLPPR2,PLPPR3,S1PR4,S1PR1,PLPPR1,PLPPR5,S1PR3,S1PR5,LPAR1,LPAR5,LPAR3
R-HSA-5467340	AXIN missense mutants destabilize the destruction complex	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	324,5525,5519,8312,5516,5527,5518,1452,5526,5515,5529,5528,2932	APC,PPP2R5A,PPP2R1B,AXIN1,PPP2CB,PPP2R5C,PPP2R1A,CSNK1A1,PPP2R5B,PPP2CA,PPP2R5E,PPP2R5D,GSK3B
R-HSA-4839748	AMER1 mutants destabilize the destruction complex	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	324,8312,5519,5516,5525,5527,5518,1452,5529,5515,5526,5528,2932	APC,AXIN1,PPP2R1B,PPP2CB,PPP2R5A,PPP2R5C,PPP2R1A,CSNK1A1,PPP2R5E,PPP2CA,PPP2R5B,PPP2R5D,GSK3B
R-HSA-4839735	AXIN mutants destabilize the destruction complex, activating WNT signaling	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	5518,324,5527,5516,8312,5519,5525,5528,2932,1452,5529,5515,5526	PPP2R1A,APC,PPP2R5C,PPP2CB,AXIN1,PPP2R1B,PPP2R5A,PPP2R5D,GSK3B,CSNK1A1,PPP2R5E,PPP2CA,PPP2R5B
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	1109,5740,23600,1646,1645,10858,8644,1593,80270,6718,11001,51302,1582	AKR1C4,PTGIS,AMACR,AKR1C2,AKR1C1,CYP46A1,AKR1C3,CYP27A1,HSD3B7,AKR1D1,SLC27A2,CYP39A1,CYP8B1
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	5111,9156,6117,6119,3978,4292,5424,4436,5395,6118,10714,2956,57804	PCNA,EXO1,RPA1,RPA3,LIG1,MLH1,POLD1,MSH2,PMS2,RPA2,POLD3,MSH6,POLD4
R-HSA-428540	Activation of Rac	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	5058,6654,8440,57144,5062,9353,6655,6091,5879,56924,2817,10298,4690	PAK1,SOS1,NCK2,PAK5,PAK2,SLIT2,SOS2,ROBO1,RAC1,PAK6,GPC1,PAK4,NCK1
R-HSA-1660516	Synthesis of PIPs at the early endosome membrane	0.478071513952185	-0.737994946902628	14	13	0.0014390081912774	9034	10285	5286,5289,9110,55300,8898,200576,3631,55697,9896,30849,22876,8821,55361	PIK3C2A,PIK3C3,MTMR4,PI4K2B,MTMR2,PIKFYVE,INPP4A,VAC14,FIG4,PIK3R4,INPP5F,INPP4B,PI4K2A
R-HSA-1483249	Inositol phosphate metabolism	0.48412916479039	-0.725403538467177	47	42	0.0046491033872039	9034	10285	5728,805,5336,11163,3633,23007,3705,3707,84812,5335,801,9562,27124,23262,5331,9807,3706,117283,8821,5330,64768,80271,5332,808,9677,3613,51196,51477,3636,9651,89869,3612,5333,122618,253430,3628,3631,51447,11165,8867,3635,23236	PTEN,CALM2,PLCG2,NUDT4,INPP5B,PLCH1,ITPK1,ITPKB,PLCD4,PLCG1,CALM1,MINPP1,INPP5J,PPIP5K2,PLCB3,IP6K1,ITPKA,IP6K3,INPP4B,PLCB2,IPPK,ITPKC,PLCB4,CALM3,PPIP5K1,IMPA2,PLCE1,ISYNA1,INPPL1,PLCH2,PLCZ1,IMPA1,PLCD1,PLD4,IPMK,INPP1,INPP4A,IP6K2,NUDT3,SYNJ1,INPP5D,PLCB1
R-HSA-1912422	Pre-NOTCH Expression and Processing	0.48412916479039	-0.725403538467177	47	42	0.0046491033872039	9034	10285	489,487,192669,10959,7157,55534,4242,4343,84441,5045,2683,22938,4853,7029,100302237,2033,192670,57690,6400,23509,10402,488,1869,23112,27161,5870,1387,7027,3516,6484,8850,4855,9794,26523,595,1871,27327,5986,3955,6487,4854,3725	ATP2A3,ATP2A1,AGO3,TMED2,TP53,MAML3,MFNG,MOV10,MAML2,FURIN,B4GALT1,SNW1,NOTCH2,TFDP2,MIR1281,EP300,AGO4,TNRC6C,SEL1L,POFUT1,ST3GAL6,ATP2A2,E2F1,TNRC6B,AGO2,RAB6A,CREBBP,TFDP1,RBPJ,ST3GAL4,KAT2B,NOTCH4,MAML1,AGO1,CCND1,E2F3,TNRC6A,RFNG,LFNG,ST3GAL3,NOTCH3,JUN
R-HSA-8948216	Collagen chain trimerization	0.48412916479039	-0.725403538467177	47	42	0.0046491033872039	9034	10285	1303,85301,7373,1290,1299,1286,131873,91522,136227,169044,84570,1284,1293,1302,100126326,1300,340267,57642,1285,1281,1310,255631,1308,1296,1280,1289,1282,1294,1298,1278,1306,1295,1301,256076,1297,1277,81578,100313843,1305,100500837,1307,50509	COL12A1,COL27A1,COL14A1,COL5A2,COL9A3,COL4A4,COL6A6,COL23A1,COL26A1,COL22A1,COL25A1,COL4A2,COL6A3,COL11A2,MIR936,COL10A1,COL28A1,COL20A1,COL4A3,COL3A1,COL19A1,COL24A1,COL17A1,COL8A2,COL2A1,COL5A1,COL4A1,COL7A1,COL9A2,COL1A2,COL15A1,COL8A1,COL11A1,COL6A5,COL9A1,COL1A1,COL21A1,MIR711,COL13A1,MIR3606,COL16A1,COL5A3
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	5095,6296,142827,35,84693,33,1632,4594,1666,3030,3032,166785,5096,27349,80724,4706,34,37,10449,3033	PCCA,ACSM3,ACSM6,ACADS,MCEE,ACADL,ECI1,MMUT,DECR1,HADHA,HADHB,MMAA,PCCB,MCAT,ACAD10,NDUFAB1,ACADM,ACADVL,ACAA2,HADH
R-HSA-202131	Metabolism of nitric oxide	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	10434,2643,114757,4846,5593,801,51070,857,207,1719,8976,1785,340481,805,5805,3320,6697,23576,808,115677	LYPLA1,GCH1,CYGB,NOS3,PRKG2,CALM1,NOSIP,CAV1,AKT1,DHFR,WASL,DNM2,ZDHHC21,CALM2,PTS,HSP90AA1,SPR,DDAH1,CALM3,NOSTRIN
R-HSA-164938	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	940,926,1173,1174,3932,51606,375,162,10053,130340,160,164,55690,920,8907,567,1175,163,3105,161	CD28,CD8B,AP2M1,AP1S1,LCK,ATP6V1H,ARF1,AP1B1,AP1M2,AP1S3,AP2A1,AP1G1,PACS1,CD4,AP1M1,B2M,AP2S1,AP2B1,HLA-A,AP2A2
R-HSA-5620916	VxPx cargo-targeting to cilium	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	117177,5311,23265,6010,11336,4218,55770,1262,8766,55763,10640,149371,50807,9727,378,8729,54536,5310,1258,60412	RAB3IP,PKD2,EXOC7,RHO,EXOC3,RAB8A,EXOC2,CNGA4,RAB11A,EXOC1,EXOC5,EXOC8,ASAP1,RAB11FIP3,ARF4,GBF1,EXOC6,PKD1,CNGB1,EXOC4
R-HSA-5654712	FRS-mediated FGFR4 signaling	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	3845,10818,3265,26281,2251,2246,2249,10817,4893,2885,2264,8817,8822,6654,9965,2253,2254,8074,5781,2247	KRAS,FRS2,HRAS,FGF20,FGF6,FGF1,FGF4,FRS3,NRAS,GRB2,FGFR4,FGF18,FGF17,SOS1,FGF19,FGF8,FGF9,FGF23,PTPN11,FGF2
R-HSA-203765	eNOS activation and regulation	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	8976,1785,857,207,1719,808,23576,115677,805,340481,3320,5805,6697,2643,10434,114757,51070,4846,5593,801	WASL,DNM2,CAV1,AKT1,DHFR,CALM3,DDAH1,NOSTRIN,CALM2,ZDHHC21,HSP90AA1,PTS,SPR,GCH1,LYPLA1,CYGB,NOSIP,NOS3,PRKG2,CALM1
R-HSA-140875	Common Pathway of Fibrin Clot Formation	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	2159,5196,2165,5657,5627,5104,5270,2153,2147,10544,7056,5197,2162,5624,2244,2243,3053,2266,462,2149	F10,PF4,F13B,PRTN3,PROS1,SERPINA5,SERPINE2,F5,F2,PROCR,THBD,PF4V1,F13A1,PROC,FGB,FGA,SERPIND1,FGG,SERPINC1,F2R
R-HSA-373753	Nephrin interactions	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	6711,8826,5290,23607,5296,8440,88,4868,6709,81,4690,9863,87,5295,8976,84623,5291,89,2534,55243	SPTBN1,IQGAP1,PIK3CA,CD2AP,PIK3R2,NCK2,ACTN2,NPHS1,SPTAN1,ACTN4,NCK1,MAGI2,ACTN1,PIK3R1,WASL,KIRREL3,PIK3CB,ACTN3,FYN,KIRREL1
R-HSA-1482801	Acyl chain remodelling of PS	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	5319,154141,114882,100137049,283748,81579,5321,114879,51365,22925,5322,30814,5320,255189,64600,114884,11145,10162,26279,123745	PLA2G1B,MBOAT1,OSBPL8,PLA2G4B,PLA2G4D,PLA2G12A,PLA2G4A,OSBPL5,PLA1A,PLA2R1,PLA2G5,PLA2G2E,PLA2G2A,PLA2G4F,PLA2G2F,OSBPL10,PLAAT3,LPCAT3,PLA2G2D,PLA2G4E
R-HSA-166663	Initial triggering of complement	0.488567488964517	-0.716277661536228	22	20	0.00221385875581138	9034	10285	10747,720,100293534,712,5648,715,2220,717,718,629,10584,714,1401,4153,713,2219,3004,78989,1675,716	MASP2,C4A,C4B_2,C1QA,MASP1,C1R,FCN2,C2,C3,CFB,COLEC10,C1QC,CRP,MBL2,C1QB,FCN1,GZMM,COLEC11,CFD,C1S
R-HSA-381340	Transcriptional regulation of white adipocyte differentiation	0.489776883774201	-0.713805330812178	88	78	0.00863404914766438	9034	10285	688,1959,892,3952,54797,79718,10499,51586,400569,1879,4023,896,9477,51003,9443,9439,84246,9370,2033,9440,948,5346,23097,10001,112950,80306,219541,10025,2167,168544,29079,5468,81857,9314,9441,8841,27332,9611,9967,5105,5970,9412,1052,10891,1024,5465,23054,23389,8648,8202,80205,7040,1051,96764,5469,9612,6517,51129,55090,9442,100302237,9969,6721,85441,90390,6720,4790,1387,1019,6604,10974,7480,6256,7471,1050,7026,7124,10498	KLF5,EGR2,CCNC,LEP,MED18,TBL1XR1,NCOA2,MED15,MED11,EBF1,LPL,CCND3,MED20,MED31,MED7,MED23,MED10,ADIPOQ,EP300,MED17,CD36,PLIN1,CDK19,MED6,MED8,MED28,MED19,MED16,FABP4,ZNF467,MED4,PPARG,MED25,KLF4,MED26,HDAC3,ZNF638,NCOR1,THRAP3,PCK1,RELA,MED21,CEBPD,PPARGC1A,CDK8,PPARA,NCOA6,MED13L,NCOA1,NCOA3,CHD9,TGFB1,CEBPB,TGS1,MED1,NCOR2,SLC2A4,ANGPTL4,MED9,MED27,MIR1281,MED13,SREBF2,HELZ2,MED30,SREBF1,NFKB1,CREBBP,CDK4,SMARCD3,ADIRF,WNT10B,RXRA,WNT1,CEBPA,NR2F2,TNF,CARM1
R-HSA-195258	RHO GTPase Effectors	0.489822603122208	-0.71371198787223	294	259	0.0286694708877574	9034	10285	348995,3817,114793,3619,79019,6396,51466,5585,57120,8970,8355,5528,4637,5586,10788,5058,147700,10552,5217,9184,9475,8346,3017,5048,8368,79980,23122,3831,4689,9735,8345,5880,57405,81929,114822,5062,9183,1856,1027,10093,25,7514,1855,10971,4688,55766,644150,79023,10006,91010,4771,11004,11113,25909,103910,389,5529,100616122,8352,8335,699,999,55055,10398,4638,8360,701,30849,5527,8343,5519,10787,10109,55746,9928,4659,147179,6242,10096,8334,89953,10092,55920,81565,4928,8353,55839,3018,54763,8367,3796,653361,5347,8341,354,1495,84643,8354,5879,991,6232,11243,5500,5518,10726,3020,57082,8344,801,1060,57551,332,3071,85415,30851,8340,60,23421,81930,57591,8363,995,8357,5216,3688,6722,124056,6249,151246,8826,79902,4085,83540,805,10163,3015,2810,1535,5595,11130,94274,64105,71,8976,8347,2017,3798,8361,51517,10458,1499,3984,8350,10097,94239,64837,23332,220134,4627,151648,6714,26999,3895,752,3012,1857,3021,7456,7532,128239,3799,147841,4221,388,5501,401541,5747,2885,8364,723790,286205,10094,23191,5516,9212,5905,79784,54908,387,1729,1063,5515,9793,8379,79172,808,79682,7529,8339,5525,23081,8358,7533,25936,653604,57122,8968,5289,64946,3013,9055,54820,5526,29941,23028,81624,998,7531,22919,10810,10095,8366,121504,8348,80152,4629,1062,126961,8365,391,8370,55845,10499,8349,50508,23279,10152,8362,5903,128312,4690,4628,8936,100302274,4660,29984,1742,1080,3985,10403,80776,1058,5594,23433,7534,5170,23380,8359,23002	NUP43,KLK2,FMNL2,INCENP,CENPM,SEC13,EVL,PKN1,GOPC,H2BC11,H3C8,PPP2R5D,MYL6,PKN2,IQGAP2,PAK1,KLC3,ARPC1A,PFN2,BUB3,ROCK2,H2BC10,H2BC5,PAFAH1B1,H4C13,DSN1,CLASP2,KLC1,NCF4,KNTC1,H2BC9,RAC2,SPC25,SEH1L,RHPN1,PAK2,ZW10,DVL2,CDKN1B,ARPC4,ABL1,XPO1,DVL1,YWHAQ,NCF2,H2AJ,WIPF3,NUP37,ABI1,FMNL3,NF2,KIF2C,CIT,AHCTF1,MYL12B,RHOC,PPP2R5E,MIR4523,H3C3,H2AC4,BUB1,CDH1,ZWILCH,MYL9,MYLK,H4C4,BUB1B,PIK3R4,PPP2R5C,H2BC7,PPP2R1B,NCKAP1,ARPC2,NUP133,KIF14,PPP1R12A,WIPF2,RTKN,ACTR3,H2AC6,KLC4,ARPC5,RCC2,NDEL1,NUP98,H3C6,CENPN,H2BC3,ROPN1,H4C5,KIF2A,NCF1,PLK1,H2BC15,KLK3,CTNNA1,KIF2B,H3C11,RAC1,CDC20,RPS27,PMF1,PPP1CB,PPP2R1A,NUDC,H3-3A,KNL1,H2BC6,CALM1,CENPC,TAOK1,BIRC5,NCKAP1L,RHPN2,TAX1BP3,H2BC13,ACTB,ITGB3BP,KIF18A,MRTFA,H4C11,CDC25C,H3C10,PFN1,ITGB1,SRF,NOXO1,CLIP1,SGO2,IQGAP1,NUP85,MAD2L1,NUF2,CALM2,WASF2,H2AZ1,SFN,CYBA,MAPK3,ZWINT,PPP1R14A,CENPK,ACTG1,WASL,H2BC4,CTTN,KIF5A,H4C6,NCKIPSD,BAIAP2,CTNNB1,LIMK1,H3C1,ACTR2,H2AZ2,KLC2,CLASP1,SKA1,MYH9,SGO1,SRC,CYFIP2,KTN1,FMNL1,H2AC8,DVL3,H3-3B,WIPF1,YWHAG,IQGAP3,KIF5B,SPC24,MEN1,RHOB,PPP1CC,CENPP,PTK2,GRB2,H4C3,H2AC19,SCAI,ARPC3,CYFIP1,PPP2CB,AURKB,RANGAP1,MYH14,SPDL1,RHOA,DIAPH1,CENPF,PPP2CA,CKAP5,MAD1L1,CENPO,CALM3,CENPU,YWHAB,H2BC8,PPP2R5A,KDM4C,H3C2,YWHAH,NSL1,H3C13,NUP107,H3C7,PIK3C3,CENPH,H2AC7,PRC1,NDE1,PPP2R5B,PKN3,KDM1A,DIAPH3,CDC42,YWHAE,MAPRE1,WASF3,ARPC1B,H4C2,H4C16,H2BC17,CENPT,MYH11,CENPE,H3C14,H4C8,RHOG,H4C14,BRK1,NCOA2,H2BC21,NOX3,NUP160,ABI2,H4C12,RANBP2,H2BC26,NCK1,MYH10,WASF1,MIR1178,PPP1R12B,RHOD,DLG4,CFTR,LIMK2,NDC80,B9D2,CENPA,MAPK1,RHOQ,YWHAZ,PDPK1,SRGAP2,H4C1,DAAM1
R-HSA-4086400	PCP/CE pathway	0.493544395595833	-0.706142463474308	96	85	0.00940889971219836	9034	10285	5710,143471,2535,7979,5880,7316,100126338,5578,5713,23198,1175,8325,5700,10197,4919,9491,7311,5699,5692,6259,8321,57154,122706,5684,4920,5707,6233,1212,7474,57216,8323,5701,409,5718,5682,5715,5216,1173,5706,5717,5881,9861,5694,144165,5711,5708,5687,23513,5719,5685,23002,387,81029,7314,5582,163,54361,8324,5686,5702,5690,5693,1211,7481,5579,8322,5695,64750,5691,1855,7976,161,7855,1213,1857,5879,5714,5720,5696,10213,160,1856,7471,5698,5704	PSMD4,PSMA8,FZD2,SEM1,RAC2,UBC,MIR937,PRKCA,PSMD7,PSME4,AP2S1,FZD8,PSMC1,PSME3,ROR1,PSMF1,UBA52,PSMB10,PSMB4,RYK,FZD1,SMURF1,PSMB11,PSMA3,ROR2,PSMD1,RPS27A,CLTB,WNT5A,VANGL2,FZD6,PSMC2,ARRB2,PSMD12,PSMA1,PSMD9,PFN1,AP2M1,PSMC6,PSMD11,RAC3,PSMD6,PSMB6,PRICKLE1,PSMD5,PSMD2,PSMA6,SCRIB,PSMD13,PSMA4,DAAM1,RHOA,WNT5B,UBB,PRKCG,AP2B1,WNT4,FZD7,PSMA5,PSMC3,PSMB2,PSMB5,CLTA,WNT11,PRKCB,FZD4,PSMB7,SMURF2,PSMB3,DVL1,FZD3,AP2A2,FZD5,CLTC,DVL3,RAC1,PSMD8,PSME1,PSMB8,PSMD14,AP2A1,DVL2,WNT1,PSMB9,PSMC4
R-HSA-446219	Synthesis of substrates in N-glycan biosythesis	0.494437945350587	-0.704333625479224	63	56	0.00619880451627186	9034	10285	54187,2673,79644,6487,29906,84620,26503,338596,29880,4597,9945,10402,55343,2720,256435,197258,5238,57171,10610,7903,51046,22845,80896,5373,6483,54344,10020,4351,6480,81849,30815,55808,29925,10825,8813,6675,116150,29926,6484,55577,7264,8869,8790,8818,55907,79947,27090,2762,4758,140838,10559,6489,5372,6482,8128,64841	NANS,GFPT1,SRD5A3,ST3GAL3,ST8SIA5,ST6GAL2,SLC17A5,ST8SIA6,ALG5,MVD,GFPT2,ST3GAL6,SLC35C1,GLB1,ST6GALNAC3,FCSK,PGM3,DOLPP1,ST6GALNAC2,ST8SIA4,ST8SIA3,DOLK,NPL,PMM2,ST3GAL2,DPM3,GNE,MPI,ST6GAL1,ST6GALNAC5,ST6GALNAC6,ST6GALNAC1,GMPPB,NEU3,DPM1,UAP1,NUS1,GMPPA,ST3GAL4,NAGK,GFUS,ST3GAL5,FPGT,DPM2,CMAS,DHDDS,ST6GALNAC4,GMDS,NEU1,NANP,SLC35A1,ST8SIA1,PMM1,ST3GAL1,ST8SIA2,GNPNAT1
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	0.495806547707417	-0.701569453120092	30	27	0.00298870932034536	9034	10285	6118,10714,27033,5985,56852,5111,6233,5981,5427,5424,56655,5984,6117,9978,7316,7314,8451,6119,54107,1642,5982,7320,57804,51514,7398,7311,5983	RPA2,POLD3,ZBTB32,RFC5,RAD18,PCNA,RPS27A,RFC1,POLE2,POLD1,POLE4,RFC4,RPA1,RBX1,UBC,UBB,CUL4A,RPA3,POLE3,DDB1,RFC2,UBE2B,POLD4,DTL,USP1,UBA52,RFC3
R-HSA-157858	Gap junction trafficking and regulation	0.495806547707417	-0.701569453120092	30	27	0.00298870932034536	9034	10285	1601,1211,7082,2706,2701,57165,2707,125111,57369,2697,219770,2703,6714,10804,2702,2700,2709,4646,8218,1785,1173,1213,1759,1212,84694,10052,127534	DAB2,CLTA,TJP1,GJB2,GJA4,GJC2,GJB3,GJD3,GJD2,GJA1,GJD4,GJA8,SRC,GJB6,GJA5,GJA3,GJB5,MYO6,CLTCL1,DNM2,AP2M1,CLTC,DNM1,CLTB,GJA10,GJC1,GJB4
R-HSA-1912408	Pre-NOTCH Transcription and Translation	0.495806547707417	-0.701569453120092	30	27	0.00298870932034536	9034	10285	4853,7029,22938,192670,57690,2033,100302237,7157,192669,84441,55534,4343,4854,27327,3725,1869,23112,27161,7027,1387,26523,1871,595,3516,4855,9794,8850	NOTCH2,TFDP2,SNW1,AGO4,TNRC6C,EP300,MIR1281,TP53,AGO3,MAML2,MAML3,MOV10,NOTCH3,TNRC6A,JUN,E2F1,TNRC6B,AGO2,TFDP1,CREBBP,AGO1,E2F3,CCND1,RBPJ,NOTCH4,MAML1,KAT2B
R-HSA-445095	Interaction between L1 and Ankyrins	0.495806547707417	-0.701569453120092	30	27	0.00298870932034536	9034	10285	287,6326,6335,6328,6712,6710,6331,51332,11280,6327,6336,6709,6334,57731,288,55800,3785,6329,6323,4897,6708,6332,6330,3786,6711,286,23114	ANK2,SCN2A,SCN9A,SCN3A,SPTBN2,SPTB,SCN5A,SPTBN5,SCN11A,SCN2B,SCN10A,SPTAN1,SCN8A,SPTBN4,ANK3,SCN3B,KCNQ2,SCN4A,SCN1A,NRCAM,SPTA1,SCN7A,SCN4B,KCNQ3,SPTBN1,ANK1,NFASC
R-HSA-76009	Platelet Aggregation (Plug Formation)	0.501381348964311	-0.690388291867015	38	34	0.00376355988487934	9034	10285	6850,2814,207,2244,6714,4352,6464,2266,54518,10235,2811,3690,9564,6654,2147,152,2815,2335,2243,1398,10411,5770,5908,151,2885,5906,5747,11069,7450,10125,150,1445,3674,5170	SYK,GP5,AKT1,FGB,SRC,MPL,SHC1,FGG,APBB1IP,RASGRP2,GP1BA,ITGB3,BCAR1,SOS1,F2,ADRA2C,GP9,FN1,FGA,CRK,RAPGEF3,PTPN1,RAP1B,ADRA2B,GRB2,RAP1A,PTK2,RAPGEF4,VWF,RASGRP1,ADRA2A,CSK,ITGA2B,PDPK1
R-HSA-1483255	PI Metabolism	0.502342635503594	-0.688472851271662	79	70	0.00774850564533983	9034	10285	5298,8394,51573,57664,3631,3635,5296,8503,51763,5291,5305,5783,133121,3636,65977,23533,5297,126282,5295,5293,5288,5286,5290,54477,59339,79626,5728,55361,80230,5287,22876,22908,5294,55697,5867,200576,64419,8867,9107,5289,8396,55300,79153,8821,25816,23760,375,23396,377,9108,59338,5868,8395,30849,8898,284161,388121,27124,10908,81544,93492,9110,22874,8871,79837,146850,84725,8897,9896,51552	PI4KB,PIP5K1A,GDE1,PLEKHA4,INPP4A,INPP5D,PIK3R2,PIK3R3,INPP5K,PIK3CB,PIP4K2A,PTPN13,ENPP6,INPPL1,PLEKHA3,PIK3R5,PI4KA,TNFAIP8L1,PIK3R1,PIK3CD,PIK3C2G,PIK3C2A,PIK3CA,PLEKHA5,PLEKHA2,TNFAIP8L2,PTEN,PI4K2A,RUFY1,PIK3C2B,INPP5F,SACM1L,PIK3CG,VAC14,RAB4A,PIKFYVE,MTMR14,SYNJ1,MTMR6,PIK3C3,PIP4K2B,PI4K2B,GDPD3,INPP4B,TNFAIP8,PITPNB,ARF1,PIP5K1C,ARF3,MTMR7,PLEKHA1,RAB5A,PIP5K1B,PIK3R4,MTMR2,GDPD1,TNFAIP8L3,INPP5J,PNPLA6,GDPD5,TPTE2,MTMR4,PLEKHA6,SYNJ2,PIP4K2C,PIK3R6,PLEKHA8,MTMR3,FIG4,RAB14
R-HSA-446652	Interleukin-1 signaling	0.505956769190977	-0.681304049726036	46	41	0.00453841044941333	9034	10285	3552,8454,54472,7311,6416,8767,246330,7189,7850,10454,3553,4215,79155,64127,3656,7314,7316,4615,57161,57162,8878,23118,3556,1147,11213,7335,1326,5608,5604,6500,51135,3554,8945,3557,23291,6885,7334,10392,6233,3551,4790	IL1A,CUL1,TOLLIP,UBA52,MAP2K4,RIPK2,PELI3,TRAF6,IL1R2,TAB1,IL1B,MAP3K3,TNIP2,NOD2,IRAK2,UBB,UBC,MYD88,PELI2,PELI1,SQSTM1,TAB2,IL1RAP,CHUK,IRAK3,UBE2V1,MAP3K8,MAP2K6,MAP2K1,SKP1,IRAK4,IL1R1,BTRC,IL1RN,FBXW11,MAP3K7,UBE2N,NOD1,RPS27A,IKBKB,NFKB1
R-HSA-2173793	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	0.505956769190977	-0.681304049726036	46	41	0.00453841044941333	9034	10285	5494,22938,7029,9612,6497,7311,7323,4089,1030,905,892,7316,6667,7314,6498,60436,5933,3065,142,4088,7050,4092,25937,54778,1874,8812,1024,904,7027,4609,64750,1875,6233,5054,7321,9611,23327,51592,3726,4087,4221	PPM1A,SNW1,TFDP2,NCOR2,SKI,UBA52,UBE2D3,SMAD4,CDKN2B,CCNT2,CCNC,UBC,SP1,UBB,SKIL,TGIF2,RBL1,HDAC1,PARP1,SMAD3,TGIF1,SMAD7,WWTR1,RNF111,E2F4,CCNK,CDK8,CCNT1,TFDP1,MYC,SMURF2,E2F5,RPS27A,SERPINE1,UBE2D1,NCOR1,NEDD4L,TRIM33,JUNB,SMAD2,MEN1
R-HSA-5621481	C-type lectin receptors (CLRs)	0.511093930449927	-0.671201888743243	144	127	0.0140580030994023	9034	10285	2033,5700,5699,7311,84433,7322,5684,805,5971,5580,10462,4585,140453,5713,143662,5706,4067,3265,5566,7335,5694,170482,56667,5534,5711,5707,6885,9039,6233,5567,5058,5718,8915,5702,4791,93978,5693,2534,3553,727897,118430,5719,7314,10892,5720,10213,200958,6714,5698,5062,50856,4773,338339,5691,3385,5714,3551,9491,5532,10197,5692,4588,122706,4893,9252,143471,5710,7316,7979,23198,5717,1147,5715,5682,6850,26253,4583,9020,3384,30835,997,808,5568,9861,5708,5970,8945,3709,23291,10071,10768,64581,5701,4772,4792,8454,5530,100302237,5686,3845,5690,2207,394263,7189,4775,10454,5336,5685,5894,5687,94025,5170,801,3708,3710,23118,5696,841,4589,6500,29108,5704,7334,7321,5695,1387,4790	EP300,PSMC1,PSMB10,UBA52,CARD11,UBE2D2,PSMA3,CALM2,RELB,PRKCD,CLEC10A,MUC4,MUC17,PSMD7,MUC15,PSMC6,LYN,HRAS,PRKACA,UBE2V1,PSMB6,CLEC4C,MUC13,PPP3R1,PSMD5,PSMD1,MAP3K7,UBA3,RPS27A,PRKACB,PAK1,PSMD12,BCL10,PSMC3,NFKB2,CLEC6A,PSMB5,FYN,IL1B,MUC5B,MUCL1,PSMD13,UBB,MALT1,PSME1,PSMD14,MUC20,SRC,PSMB9,PAK2,CLEC4A,NFATC2,CLEC4D,PSMB3,ICAM3,PSMD8,IKBKB,PSMF1,PPP3CB,PSME3,PSMB4,MUC6,PSMB11,NRAS,RPS6KA5,PSMA8,PSMD4,UBC,SEM1,PSME4,PSMD11,CHUK,PSMD9,PSMA1,SYK,CLEC4E,MUC2,MAP3K14,ICAM2,CD209,CDC34,CALM3,PRKACG,PSMD6,PSMD2,RELA,BTRC,ITPR2,FBXW11,MUC12,AHCYL1,CLEC7A,PSMC2,NFATC1,NFKBIA,CUL1,PPP3CA,MIR1281,PSMA5,KRAS,PSMB2,FCER1G,MUC21,TRAF6,NFATC3,TAB1,PLCG2,PSMA4,RAF1,PSMA6,MUC16,PDPK1,CALM1,ITPR1,ITPR3,TAB2,PSMB8,CASP8,MUC7,SKP1,PYCARD,PSMC4,UBE2N,UBE2D1,PSMB7,CREBBP,NFKB1
R-HSA-69206	G1/S Transition	0.516862605462884	-0.659978193249119	119	105	0.0116227584680097	9034	10285	595,5111,6233,5707,5718,4998,1869,5925,6118,7084,5706,5711,5694,5558,898,5713,55388,5699,7311,5700,5684,1022,7298,4174,1019,7027,1027,5714,5691,207,10213,5001,5720,4331,8318,1026,990,5698,4173,891,7314,4999,5515,5719,23595,6119,4171,993,5702,5516,208,6241,5693,5427,902,5701,4172,1719,23649,5717,5682,6117,5519,5715,5708,6502,9861,56655,23594,5710,7979,7316,26271,4149,5692,5557,10197,9491,54107,7029,1017,5695,8317,84515,4609,890,5696,8900,5704,6500,4175,5685,7465,5687,81620,10000,9134,5000,5690,8454,5686,5753,5518,10926,983	CCND1,PCNA,RPS27A,PSMD1,PSMD12,ORC1,E2F1,RB1,RPA2,TK2,PSMC6,PSMD5,PSMB6,PRIM2,CCNE1,PSMD7,MCM10,PSMB10,UBA52,PSMC1,PSMA3,CDK7,TYMS,MCM5,CDK4,TFDP1,CDKN1B,PSMD8,PSMB3,AKT1,PSMD14,ORC5,PSME1,MNAT1,CDC45,CDKN1A,CDC6,PSMB9,MCM4,CCNB1,UBB,ORC2,PPP2CA,PSMD13,ORC3,RPA3,MCM2,CDC25A,PSMC3,PPP2CB,AKT2,RRM2,PSMB5,POLE2,CCNH,PSMC2,MCM3,DHFR,POLA2,PSMD11,PSMA1,RPA1,PPP2R1B,PSMD9,PSMD2,SKP2,PSMD6,POLE4,ORC6,PSMD4,SEM1,UBC,FBXO5,MAX,PSMB4,PRIM1,PSME3,PSMF1,POLE3,TFDP2,CDK2,PSMB7,CDC7,MCM8,MYC,CCNA2,PSMB8,CCNA1,PSMC4,SKP1,MCM6,PSMA4,WEE1,PSMA6,CDT1,AKT3,CCNE2,ORC4,PSMB2,CUL1,PSMA5,PTK6,PPP2R1A,DBF4,CDK1
R-HSA-202403	TCR signaling	0.516862605462884	-0.659978193249119	119	105	0.0116227584680097	9034	10285	5718,3119,3127,5058,6233,6885,3702,5707,5711,55740,5694,2533,7335,51466,5706,5713,3937,5684,7322,84433,3120,7311,7535,5699,5700,3551,5714,5691,27040,3635,3113,5296,5062,3932,5698,50852,10213,5720,5295,10892,915,1445,3118,7314,5290,5719,5788,5693,3122,8767,8915,5702,4792,5701,9402,7408,5588,23291,8945,5970,9398,5708,9861,997,5682,5715,5717,1147,23198,26191,7316,7979,920,5710,143471,122706,3123,5692,10197,9491,4790,4690,55824,5695,7334,7321,5795,5704,5291,6500,916,5696,23118,5335,917,919,5170,5687,5685,5728,7189,3117,5690,5686,8454	PSMD12,HLA-DQB1,HLA-DRB5,PAK1,RPS27A,MAP3K7,ITK,PSMD1,PSMD5,ENAH,PSMB6,FYB1,UBE2V1,EVL,PSMC6,PSMD7,LCP2,PSMA3,UBE2D2,CARD11,HLA-DQB2,UBA52,ZAP70,PSMB10,PSMC1,IKBKB,PSMD8,PSMB3,LAT,INPP5D,HLA-DPA1,PIK3R2,PAK2,LCK,PSMB9,TRAT1,PSMD14,PSME1,PIK3R1,MALT1,CD3D,CSK,HLA-DQA2,UBB,PIK3CA,PSMD13,PTPRC,PSMB5,HLA-DRA,RIPK2,BCL10,PSMC3,NFKBIA,PSMC2,GRAP2,VASP,PRKCQ,FBXW11,BTRC,RELA,CD101,PSMD2,PSMD6,CDC34,PSMA1,PSMD9,PSMD11,CHUK,PSME4,PTPN22,UBC,SEM1,CD4,PSMD4,PSMA8,PSMB11,HLA-DRB1,PSMB4,PSME3,PSMF1,NFKB1,NCK1,PAG1,PSMB7,UBE2N,UBE2D1,PTPRJ,PSMC4,PIK3CB,SKP1,CD3E,PSMB8,TAB2,PLCG1,CD3G,CD247,PDPK1,PSMA6,PSMA4,PTEN,TRAF6,HLA-DQA1,PSMB2,PSMA5,CUL1
R-HSA-1852241	Organelle biogenesis and maintenance	0.517672728422584	-0.658412034803375	340	299	0.0330971883993801	9034	10285	64969,121441,78988,57576,740,6991,5600,4867,1639,149371,5577,51649,200186,10576,10142,5565,506,92482,11336,8729,140735,93323,5465,5566,23054,4957,116541,26160,11020,80205,9702,129880,28981,22994,8648,10121,5147,9793,6010,3396,5310,54460,84311,51259,64216,85441,55212,56945,27241,100616329,27031,92399,23082,64978,63875,7532,7840,10540,79598,23332,51642,60412,55755,1432,60488,54806,11064,347240,22995,65008,8100,54998,28957,64792,57560,10499,23265,64963,51373,7531,5563,22919,582,3797,54534,55764,1454,65080,54820,55112,10694,6608,92104,51098,1781,54801,55052,27077,10806,79441,23322,10891,64951,51253,92259,10382,1453,29088,57129,51023,51263,51626,10573,11258,6300,84902,80776,57545,80184,50807,11127,4899,2101,1387,123263,150737,79989,57728,55835,51021,54205,79590,5564,261734,90480,51318,95681,9321,55722,23354,56912,64928,84100,5048,64979,26005,133522,4528,64983,4208,51258,64981,64784,10575,55168,9611,7818,117177,22981,23373,22897,51650,6742,85302,26123,63931,9553,9742,79659,29093,9801,54930,8766,96764,7846,166379,85476,10240,51422,11190,54536,9727,219927,55125,124995,84340,79809,65003,7019,54516,26146,79969,122704,64965,89891,64968,4209,9572,6183,2551,79959,64976,11232,83657,9657,54585,8195,64432,80173,9814,79600,203068,1778,28977,7277,79718,57787,112752,5347,4218,378,26589,128308,132320,80321,5571,23410,1258,23059,22920,55763,91147,55037,84747,51073,51668,54948,5108,123016,54903,8841,100616256,3842,9662,22948,80254,51134,84545,115106,11222,116540,585,6182,79867,79738,5442,84131,10102,23107,5469,583,2847,6753,200132,1262,146057,53632,5518,403,57539,3320,118487,10884,983,192668,55173,10640,4751,1385,255758,8655,10733,211,55081,22832,51264,7978,55770,6604,5311,28998,1386,54148,51106,64960,6256,10498,219402,83658	MRPS5,NEDD1,MRPL57,KIF17,MRPL49,DYNLT2,MAPK11,NPHP1,DCTN1,EXOC8,PRKAR2B,MRPS23,CRTC2,CCT2,AKAP9,PRKAB2,ATP5F1B,BBIP1,EXOC3,GBF1,DYNLL2,HAUS8,PPARA,PRKACA,NCOA6,ODF2,MRPL54,IFT172,IFT27,CHD9,CEP57,BBS5,IFT81,CEP131,NCOA1,ACTR1A,PDE6D,CKAP5,RHO,MRPL58,PKD1,MRPS21,MRPL45,TMEM216,TFB2M,HELZ2,BBS7,MRPS22,BBS9,MIR4700,NPHP3,MRRF,PPRC1,MRPL38,MRPL17,YWHAG,ALMS1,DCTN2,CEP97,CLASP1,MRPL48,EXOC4,CDK5RAP2,MAPK14,MRPS35,AHI1,CNTRL,KIF24,CEP152,MRPL1,IFT88,AURKAIP1,MRPS28,IFT22,IFT80,NCOA2,EXOC7,MRPS11,MRPS17,YWHAE,PRKAA2,MAPRE1,BBS1,KIF3C,MRPL50,IFT122,CSNK1E,MRPL44,NDE1,DYNC2I1,CCT8,SMO,IFT70A,IFT52,DYNC1I2,HAUS6,MRPL20,B9D1,SDCCAG8,HAUS3,RPGRIP1L,PPARGC1A,MRPS24,MRPL37,KGD4,TUBB4A,CSNK1D,MRPL15,MRPL47,MRPS18C,MRPL30,DYNC2LI1,MRPL28,DCTN3,MAPK12,CEP89,B9D2,CC2D2A,CEP290,ASAP1,KIF3A,NRF1,ESRRA,CREBBP,MTFMT,IFT70B,IFT56,WDR19,CENPJ,MRPS16,CYCS,MRPL24,PRKAB1,NPHP4,GADD45GIP1,MRPL35,CEP41,TRIP11,CEP72,HAUS5,IFT46,MRPL14,ARL6,PAFAH1B1,MRPL36,C2CD3,PPARGC1B,MTIF2,MRPL32,MEF2C,MRPL51,MRPL34,CRTC3,CCT4,MRPS18A,NCOR1,DAP3,RAB3IP,NINL,CRTC1,CEP164,MRPS33,SSBP1,FBF1,TCTN3,MRPS14,MRPL33,IFT140,DYNC2H1,MRPL22,MRPL19,HAUS4,RAB11A,TGS1,TUBA1A,BBS12,GFM1,MRPS31,PRKAG2,CEP250,EXOC6,RAB11FIP3,MRPL21,CEP192,MRPL10,GFM2,TTC21B,MRPL11,TFAM,MTRF1L,TRAF3IP1,ATAT1,MRPL52,MRPS9,DYNC2I2,MRPS6,MEF2D,NR1D1,MRPS12,GABPA,CEP76,MRPL40,POLG2,DYNLRB2,IQCB1,LZTFL1,MKKS,MRPS25,IFT74,SFI1,TCTN1,TUBB,DYNC1H1,MRPL42,TUBA4A,TBL1XR1,MARK4,IFT43,PLK1,RAB8A,ARF4,MRPL46,MRPL55,SCLT1,CEP70,PRKAG1,SIRT3,CNGB1,CLUAP1,KIFAP3,EXOC1,TMEM67,PTCD3,UNC119B,MRPL4,IFT25,MRPL16,PCM1,TTC8,MKS1,HDAC3,MIR4721,TNPO1,CEP135,CCT5,CEP63,CEP83,MRPL43,HAUS1,MRPL3,MRPL53,BBS4,MRPL12,TCTN2,BBS10,POLRMT,CEP78,TSFM,MRPS27,MED1,BBS2,MCHR1,SSTR3,DYNLT5,CNGA4,TTBK2,PRKAG3,PPP2R1A,ARL3,WDR35,HSP90AA1,CHCHD1,MRPS30,CDK1,CYS1,MRPS10,EXOC5,NEK2,CREB1,DYNLT2B,DYNLL1,PLK4,ALAS1,IFT57,CEP162,MRPL27,MTERF1,EXOC2,SMARCD3,PKD2,MRPL13,ATF2,MRPL39,TFB1M,MRPS15,RXRA,CARM1,MTIF3,DYNLRB1
R-HSA-3134963	DEx/H-box helicases activate type I IFN and inflammatory cytokines production	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	5970,177,351,1660,6283,4791,6288,4790,170506,4615,3146,3665	RELA,AGER,APP,DHX9,S100A12,NFKB2,SAA1,NFKB1,DHX36,MYD88,HMGB1,IRF7
R-HSA-2168880	Scavenging of heme from plasma	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	3039,3263,3043,259,3240,3512,9332,8542,3250,4035,213,335	HBA1,HPX,HBB,AMBP,HP,JCHAIN,CD163,APOL1,HPR,LRP1,ALB,APOA1
R-HSA-3270619	IRF3-mediated induction of type I IFN	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	5591,197358,3661,3428,2547,23220,4361,29110,7520,340061,11277,147945	PRKDC,NLRC3,IRF3,IFI16,XRCC6,DTX4,MRE11,TBK1,XRCC5,STING1,TREX1,NLRP4
R-HSA-198323	AKT phosphorylates targets in the cytosol	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	207,2931,1147,208,1026,4193,842,10000,1027,84335,2932,7249	AKT1,GSK3A,CHUK,AKT2,CDKN1A,MDM2,CASP9,AKT3,CDKN1B,AKT1S1,GSK3B,TSC2
R-HSA-375281	Hormone ligand-binding receptors	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	7253,2798,2488,7252,2492,2796,122876,3972,3973,170589,2797,1081	TSHR,GNRHR,FSHB,TSHB,FSHR,GNRH1,GPHB5,LHB,LHCGR,GPHA2,GNRH2,CGA
R-HSA-190375	FGFR2c ligand binding and activation	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	2263,2251,2249,2246,26281,2253,2254,8074,2247,2250,8817,8822	FGFR2,FGF6,FGF4,FGF1,FGF20,FGF8,FGF9,FGF23,FGF2,FGF5,FGF18,FGF17
R-HSA-2197563	NOTCH2 intracellular domain regulates transcription	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	3280,100302237,2033,4853,3002,84441,388585,9794,55534,3516,1385,2208	HES1,MIR1281,EP300,NOTCH2,GZMB,MAML2,HES5,MAML1,MAML3,RBPJ,CREB1,FCER2
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	51167,6521,6005,606495,759,358,51706,762,3043,3039,51700,760	CYB5R4,SLC4A1,RHAG,CYB5RL,CA1,AQP1,CYB5R1,CA4,HBB,HBA1,CYB5R2,CA2
R-HSA-5357786	TNFR1-induced proapoptotic signaling	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	9099,841,7128,7124,7132,8737,27005,8772,8717,7375,56957,1540	USP2,CASP8,TNFAIP3,TNF,TNFRSF1A,RIPK1,USP21,FADD,TRADD,USP4,OTUD7B,CYLD
R-HSA-933543	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	84282,8772,8737,64135,3551,1147,57506,841,100500827,843,7706,23586	RNF135,FADD,RIPK1,IFIH1,IKBKB,CHUK,MAVS,CASP8,MIR3614,CASP10,TRIM25,RIGI
R-HSA-1480926	O2/CO2 exchange in erythrocytes	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	6005,6521,51167,3043,51706,3039,759,358,606495,762,51700,760	RHAG,SLC4A1,CYB5R4,HBB,CYB5R1,HBA1,CA1,AQP1,CYB5RL,CA4,CYB5R2,CA2
R-HSA-202670	ERKs are inactivated	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	1846,1849,5515,5528,5594,51231,5598,1848,5595,5519,5516,5518	DUSP4,DUSP7,PPP2CA,PPP2R5D,MAPK1,VRK3,MAPK7,DUSP6,MAPK3,PPP2R1B,PPP2CB,PPP2R1A
R-HSA-190239	FGFR3 ligand binding and activation	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	2253,2254,8074,2247,2261,8817,8822,2250,2246,2249,2591,26281	FGF8,FGF9,FGF23,FGF2,FGFR3,FGF18,FGF17,FGF5,FGF1,FGF4,GALNT3,FGF20
R-HSA-264870	Caspase-mediated cleavage of cytoskeletal proteins	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	6709,7431,836,118,840,2934,839,5339,28988,2620,841,4137	SPTAN1,VIM,CASP3,ADD1,CASP7,GSN,CASP6,PLEC,DBNL,GAS2,CASP8,MAPT
R-HSA-2029481	FCGR activation	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	2268,917,919,9103,2534,2214,6714,2209,2212,6850,7525,4067	FGR,CD3G,CD247,FCGR2C,FYN,FCGR3A,SRC,FCGR1A,FCGR2A,SYK,YES1,LYN
R-HSA-8866907	Activation of the TFAP2 (AP-2) family of transcription factors	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	83741,339488,8089,163732,7021,2033,100302237,51741,10370,7020,1387,7022	TFAP2D,TFAP2E,YEATS4,CITED4,TFAP2B,EP300,MIR1281,WWOX,CITED2,TFAP2A,CREBBP,TFAP2C
R-HSA-1502540	Signaling by Activin	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	3624,10272,4087,93,4088,91,3625,10468,130399,4089,92,10589	INHBA,FSTL3,SMAD2,ACVR2B,SMAD3,ACVR1B,INHBB,FST,ACVR1C,SMAD4,ACVR2A,DRAP1
R-HSA-432047	Passive transport by Aquaporins	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	362,360,375318,282679,343,359,366,363,89872,358,361,364	AQP5,AQP3,AQP12A,AQP11,AQP8,AQP2,AQP9,AQP6,AQP10,AQP1,AQP4,AQP7
R-HSA-75892	Platelet Adhesion to exposed collagen	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	2814,2207,4067,2534,3672,7450,2811,8515,3688,2815,3673,51206	GP5,FCER1G,LYN,FYN,ITGA1,VWF,GP1BA,ITGA10,ITGB1,GP9,ITGA2,GP6
R-HSA-74217	Purine salvage	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	1716,1633,271,161823,353,4860,100,2766,132,51292,270,272	DGUOK,DCK,AMPD2,ADAL,APRT,PNP,ADA,GMPR,ADK,GMPR2,AMPD1,AMPD3
R-HSA-190372	FGFR3c ligand binding and activation	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	8074,2253,2254,2247,2261,8817,8822,2250,2246,2249,2591,26281	FGF23,FGF8,FGF9,FGF2,FGFR3,FGF18,FGF17,FGF5,FGF1,FGF4,GALNT3,FGF20
R-HSA-5654227	Phospholipase C-mediated cascade; FGFR3	0.518667362841565	-0.65649252067329	13	12	0.00132831525348683	9034	10285	26281,2250,8817,8822,5335,2261,2253,2254,8074,2246,2249,2247	FGF20,FGF5,FGF18,FGF17,PLCG1,FGFR3,FGF8,FGF9,FGF23,FGF1,FGF4,FGF2
R-HSA-1810476	RIP-mediated NFkB activation via ZBP1	0.520756752175754	-0.652472232673069	21	19	0.00210316581802081	9034	10285	4793,3146,4615,148022,4790,4792,3551,6288,1147,4791,7098,6283,1660,11035,81030,351,177,5970,8737	NFKBIB,HMGB1,MYD88,TICAM1,NFKB1,NFKBIA,IKBKB,SAA1,CHUK,NFKB2,TLR3,S100A12,DHX9,RIPK3,ZBP1,APP,AGER,RELA,RIPK1
R-HSA-196741	Cobalamin (Cbl, vitamin B12) transport and metabolism	0.520756752175754	-0.652472232673069	21	19	0.00210316581802081	9034	10285	55788,1504,27249,2694,4552,51293,11330,4594,326625,4363,5646,166785,6947,4548,5826,440387,81693,8029,5644	LMBRD1,CTRB1,MMADHC,CBLIF,MTRR,CD320,CTRC,MMUT,MMAB,ABCC1,PRSS3,MMAA,TCN1,MTR,ABCD4,CTRB2,AMN,CUBN,PRSS1
R-HSA-2028269	Signaling by Hippo	0.520756752175754	-0.652472232673069	21	19	0.00210316581802081	9034	10285	25937,7529,261734,9414,26524,51421,1856,7082,7531,55233,23286,92597,6788,154810,6789,836,10413,9113,60485	WWTR1,YWHAB,NPHP4,TJP2,LATS2,AMOTL2,DVL2,TJP1,YWHAE,MOB1A,WWC1,MOB1B,STK3,AMOTL1,STK4,CASP3,YAP1,LATS1,SAV1
R-HSA-2022870	Chondroitin sulfate biosynthesis	0.520756752175754	-0.652472232673069	21	19	0.00210316581802081	9034	10285	79586,337876,768213,55454,63827,51363,83539,55501,22856,1462,10675,55790,54480,50515,1634,1464,1463,9469,166012	CHPF,CHSY3,MIR671,CSGALNACT2,BCAN,CHST15,CHST9,CHST12,CHSY1,VCAN,CSPG5,CSGALNACT1,CHPF2,CHST11,DCN,CSPG4,NCAN,CHST3,CHST13
R-HSA-187024	NGF-independant TRKA activation	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	4914,117,4915,116,135	NTRK1,ADCYAP1R1,NTRK2,ADCYAP1,ADORA2A
R-HSA-68911	G2 Phase	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	1017,1871,1869,8900,890	CDK2,E2F3,E2F1,CCNA1,CCNA2
R-HSA-3065676	SUMO is conjugated to E1 (UBA2:SAE1)	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	6612,10055,7341,10054,6613	SUMO3,SAE1,SUMO1,UBA2,SUMO2
R-HSA-426048	Arachidonate production from DAG	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	26090,11343,747,221955,57406	ABHD12,MGLL,DAGLA,DAGLB,ABHD6
R-HSA-75157	FasL/ CD95L signaling	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	355,8772,841,356,843	FAS,FADD,CASP8,FASLG,CASP10
R-HSA-1300652	Sperm:Oocyte Membrane Binding	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	928,100129669,284359,113177,126123	CD9,IZUMO3,IZUMO1,IZUMO4,IZUMO2
R-HSA-112307	Transmission across Electrical Synapses	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	57369,56666,24145,10052,84694	GJD2,PANX2,PANX1,GJC1,GJA10
R-HSA-380095	Tachykinin receptors bind tachykinins	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	6863,6870,6865,6866,6869	TAC1,TACR3,TACR2,TAC3,TACR1
R-HSA-8875513	MET interacts with TNS proteins	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	4233,64759,84951,3688,3082	MET,TNS3,TNS4,ITGB1,HGF
R-HSA-111448	Activation of NOXA and translocation to mitochondria	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	1869,7157,7029,7027,5366	E2F1,TP53,TFDP2,TFDP1,PMAIP1
R-HSA-390648	Muscarinic acetylcholine receptors	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	1128,1133,1131,1132,1129	CHRM1,CHRM5,CHRM3,CHRM4,CHRM2
R-HSA-114516	Disinhibition of SNARE formation	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	6814,5579,5582,5578,6810	STXBP3,PRKCB,PRKCG,PRKCA,STX4
R-HSA-69478	G2/M DNA replication checkpoint	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	7465,9133,983,891,9088	WEE1,CCNB2,CDK1,CCNB1,PKMYT1
R-HSA-74713	IRS activation	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	3643,8660,2887,3630,3667	INSR,IRS2,GRB10,INS,IRS1
R-HSA-2161517	Abacavir transmembrane transport	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	6582,9429,6580,5243,6581	SLC22A2,ABCG2,SLC22A1,ABCB1,SLC22A3
R-HSA-5661270	Catabolism of glucuronate to xylulose-5-phosphate	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	51181,6652,9942,51084,10327	DCXR,SORD,XYLB,CRYL1,AKR1A1
R-HSA-111461	Cytochrome c-mediated apoptotic response	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	317,54205,840,836,842	APAF1,CYCS,CASP7,CASP3,CASP9
R-HSA-390651	Dopamine receptors	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	1813,1814,1815,1816,1812	DRD2,DRD3,DRD4,DRD5,DRD1
R-HSA-70350	Fructose catabolism	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	229,132158,26007,3795,216	ALDOB,GLYCTK,TKFC,KHK,ALDH1A1
R-HSA-8852405	Signaling by MST1	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	4485,4486,10653,3249,6692	MST1,MST1R,SPINT2,HPN,SPINT1
R-HSA-1483226	Synthesis of PI	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	9600,1040,83394,57605,10423	PITPNM1,CDS1,PITPNM3,PITPNM2,CDIPT
R-HSA-203641	NOSTRIN mediated eNOS trafficking	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	4846,857,8976,115677,1785	NOS3,CAV1,WASL,NOSTRIN,DNM2
R-HSA-446205	Synthesis of GDP-mannose	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	5372,4351,29925,5373,29926	PMM1,MPI,GMPPB,PMM2,GMPPA
R-HSA-2161541	Abacavir metabolism	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	124,5105,22978,161823,2987	ADH1A,PCK1,NT5C2,ADAL,GUK1
R-HSA-112303	Electric Transmission Across Gap Junctions	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	10052,84694,56666,57369,24145	GJC1,GJA10,PANX2,GJD2,PANX1
R-HSA-964739	N-glycan trimming and elongation in the cis-Golgi	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	57134,4121,4245,79694,10905	MAN1C1,MAN1A1,MGAT1,MANEA,MAN1A2
R-HSA-8866911	TFAP2 (AP-2) family regulates transcription of cell cycle factors	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	1026,7022,7020,10765,4609	CDKN1A,TFAP2C,TFAP2A,KDM5B,MYC
R-HSA-5250981	Toxicity of botulinum toxin type F (BoNT/F)	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	9900,9899,22987,6843,6844	SV2A,SV2B,SV2C,VAMP1,VAMP2
R-HSA-1169092	Activation of RAS in B cells	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	25780,3845,3265,10125,4893	RASGRP3,KRAS,HRAS,RASGRP1,NRAS
R-HSA-5662702	Melanin biosynthesis	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	51151,4948,7306,1638,7299	SLC45A2,OCA2,TYRP1,DCT,TYR
R-HSA-8853383	Lysosomal oligosaccharide catabolism	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	4123,23324,4125,693216,4126	MAN2C1,MAN2B2,MAN2B1,MIR631,MANBA
R-HSA-389599	Alpha-oxidation of phytanate	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	224,5264,26061,11001,10478	ALDH3A2,PHYH,HACL1,SLC27A2,SLC25A17
R-HSA-8849468	PTK6 Regulates Proteins Involved in RNA Processing	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	202559,10657,6421,5753,10656	KHDRBS2,KHDRBS1,SFPQ,PTK6,KHDRBS3
R-HSA-180689	APOBEC3G mediated resistance to HIV-1 infection	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	3159,8815,60489,11168,5478	HMGA1,BANF1,APOBEC3G,PSIP1,PPIA
R-HSA-71032	Propionyl-CoA catabolism	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	166785,5096,5095,4594,84693	MMAA,PCCB,PCCA,MMUT,MCEE
R-HSA-5250955	Toxicity of botulinum toxin type D (BoNT/D)	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	22987,6843,6844,9899,9900	SV2C,VAMP1,VAMP2,SV2B,SV2A
R-HSA-196819	Vitamin B1 (thiamin) metabolism	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	60386,79178,10560,80704,27010	SLC25A19,THTPA,SLC19A2,SLC19A3,TPK1
R-HSA-210746	Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	50674,3642,4760,4821,5078	NEUROG3,INSM1,NEUROD1,NKX2-2,PAX4
R-HSA-157881	Cyclin B2 mediated events	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	9133,995,993,983,994	CCNB2,CDC25C,CDC25A,CDK1,CDC25B
R-HSA-2142850	Hyaluronan biosynthesis and export	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	3038,3036,10057,3037,57214	HAS3,HAS1,ABCC5,HAS2,CEMIP
R-HSA-8849473	PTK6 Expression	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	2908,27043,3091,5753,2034	NR3C1,PELP1,HIF1A,PTK6,EPAS1
R-HSA-444209	Free fatty acid receptors	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	2864,338557,2865,2867,2853	FFAR1,FFAR4,FFAR3,FFAR2,GPR31
R-HSA-70370	Galactose catabolism	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	2582,5236,55276,2584,2592	GALE,PGM1,PGM2,GALK1,GALT
R-HSA-3000471	Scavenging by Class B Receptors	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	6288,338,948,335,949	SAA1,APOB,CD36,APOA1,SCARB1
R-HSA-8865999	MET activates PTPN11	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	2549,4233,5781,2885,3082	GAB1,MET,PTPN11,GRB2,HGF
R-HSA-111459	Activation of caspases through apoptosome-mediated cleavage	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	840,836,842,317,54205	CASP7,CASP3,CASP9,APAF1,CYCS
R-HSA-561048	Organic anion transport	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	116085,10864,9376,55867,9356	SLC22A12,SLC22A7,SLC22A8,SLC22A11,SLC22A6
R-HSA-1606341	IRF3 mediated activation of type 1 IFN	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	81030,23220,147945,3661,29110	ZBP1,DTX4,NLRP4,IRF3,TBK1
R-HSA-111932	CaMK IV-mediated phosphorylation of CREB	0.522781799667839	-0.648591111021233	5	5	0.000553464688952845	9034	10285	801,805,1385,814,808	CALM1,CALM2,CREB1,CAMK4,CALM3
R-HSA-164952	The role of Nef in HIV-1 replication and disease pathogenesis	0.523299007352406	-0.647602262505439	29	26	0.00287801638255479	9034	10285	160,162,2534,375,10053,130340,3932,5062,51606,1174,926,1173,940,3105,161,163,1794,567,919,1175,5879,9844,8907,920,55690,164	AP2A1,AP1B1,FYN,ARF1,AP1M2,AP1S3,LCK,PAK2,ATP6V1H,AP1S1,CD8B,AP2M1,CD28,HLA-A,AP2A2,AP2B1,DOCK2,B2M,CD247,AP2S1,RAC1,ELMO1,AP1M1,CD4,PACS1,AP1G1
R-HSA-442742	CREB phosphorylation through the activation of Ras	0.523299007352406	-0.647602262505439	29	26	0.00287801638255479	9034	10285	4747,6195,673,1385,10142,2905,816,2904,3265,5924,6196,818,2906,808,5894,801,5594,88,5170,2903,5923,815,805,817,6237,1742	NEFL,RPS6KA1,BRAF,CREB1,AKAP9,GRIN2C,CAMK2B,GRIN2B,HRAS,RASGRF2,RPS6KA2,CAMK2G,GRIN2D,CALM3,RAF1,CALM1,MAPK1,ACTN2,PDPK1,GRIN2A,RASGRF1,CAMK2A,CALM2,CAMK2D,RRAS,DLG4
R-HSA-419037	NCAM1 interactions	0.525772829079089	-0.642886043413189	37	33	0.00365286694708878	9034	10285	8912,4684,1285,6900,2668,8913,783,375790,1286,131873,1299,1293,5623,1463,1284,779,784,775,785,2675,4902,1297,7903,9048,256076,64096,776,8128,5621,1282,1298,2674,8911	CACNA1H,NCAM1,COL4A3,CNTN2,GDNF,CACNA1G,CACNB2,AGRN,COL4A4,COL6A6,COL9A3,COL6A3,PSPN,NCAN,COL4A2,CACNA1S,CACNB3,CACNA1C,CACNB4,GFRA2,NRTN,COL9A1,ST8SIA4,ARTN,COL6A5,GFRA4,CACNA1D,ST8SIA2,PRNP,COL4A1,COL9A2,GFRA1,CACNA1I
R-HSA-166658	Complement cascade	0.528104883640156	-0.638460371744964	45	40	0.00442771751162276	9034	10285	3075,728,100293534,722,1604,1191,629,732,3426,718,2220,5648,5627,712,714,10878,716,1675,3004,1378,713,720,729,727,725,10747,730,735,717,719,715,966,4153,1401,27202,10584,731,78989,4179,2219	CFH,C5AR1,C4B_2,C4BPA,CD55,CLU,CFB,C8B,CFI,C3,FCN2,MASP1,PROS1,C1QA,C1QC,CFHR3,C1S,CFD,GZMM,CR1,C1QB,C4A,C6,C5,C4BPB,MASP2,C7,C9,C2,C3AR1,C1R,CD59,MBL2,CRP,C5AR2,COLEC10,C8A,COLEC11,CD46,FCN1
R-HSA-2151201	Transcriptional activation of mitochondrial biogenesis	0.528104883640156	-0.638460371744964	45	40	0.00442771751162276	9034	10285	211,7978,9611,506,6604,8841,7019,1385,200186,23082,1387,64784,5465,10498,6742,23054,10891,1386,4209,23373,9572,2551,54205,11232,6256,51106,96764,5469,79718,10499,5442,80205,8648,64216,133522,85441,2101,4208,4899,23410	ALAS1,MTERF1,NCOR1,ATP5F1B,SMARCD3,HDAC3,TFAM,CREB1,CRTC2,PPRC1,CREBBP,CRTC3,PPARA,CARM1,SSBP1,NCOA6,PPARGC1A,ATF2,MEF2D,CRTC1,NR1D1,GABPA,CYCS,POLG2,RXRA,TFB1M,TGS1,MED1,TBL1XR1,NCOA2,POLRMT,CHD9,NCOA1,TFB2M,PPARGC1B,HELZ2,ESRRA,MEF2C,NRF1,SIRT3
R-HSA-159234	Transport of Mature mRNAs Derived from Intronless Transcripts	0.528104883640156	-0.638460371744964	45	40	0.00442771751162276	9034	10285	4927,7884,51692,9883,8021,55339,79023,11097,8086,55706,9688,10189,81608,81929,9631,10482,53981,7175,4928,129401,9818,100101267,23636,23165,5903,10762,1977,22916,23279,348995,23511,79902,9972,8189,23225,53371,57122,10898,55746,4686	NUP88,SLBP,CPSF3,POM121,NUP214,WDR33,NUP37,NUP42,AAAS,NDC1,NUP93,ALYREF,FIP1L1,SEH1L,NUP155,NXF1,CPSF2,TPR,NUP98,NUP35,NUP58,POM121C,NUP62,NUP205,RANBP2,NUP50,EIF4E,NCBP2,NUP160,NUP43,NUP188,NUP85,NUP153,SYMPK,NUP210,NUP54,NUP107,CPSF4,NUP133,NCBP1
R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	0.528104883640156	-0.638460371744964	45	40	0.00442771751162276	9034	10285	8795,1387,8797,317,84883,64065,581,27166,834,147923,79370,7159,10397,8794,604,7161,10650,94241,355,5876,27113,7157,55367,23368,8738,9540,124446,3486,332,839,5366,8626,835,55240,8793,58484,843,665,63970,472	TNFRSF10B,CREBBP,TNFRSF10A,APAF1,AIFM2,PERP,BAX,PRELID1,CASP1,ZNF420,BCL2L14,TP53BP2,NDRG1,TNFRSF10C,BCL6,TP73,PRELID3A,TP53INP1,FAS,RABGGTB,BBC3,TP53,PIDD1,PPP1R13B,CRADD,TP53I3,TMEM219,IGFBP3,BIRC5,CASP6,PMAIP1,TP63,CASP2,STEAP3,TNFRSF10D,NLRC4,CASP10,BNIP3L,TP53AIP1,ATM
R-HSA-8854214	TBC/RABGAPs	0.528104883640156	-0.638460371744964	45	40	0.00442771751162276	9034	10285	5867,26088,5870,79735,125058,23637,23062,64786,57465,7248,382,83452,84958,83874,51256,11337,128637,5868,10133,7249,11345,8766,57533,23163,54662,100616314,5878,27342,4218,51762,26000,5869,2844,7879,51560,55357,8408,81631,11021,9135	RAB4A,GGA1,RAB6A,TBC1D17,TBC1D16,RABGAP1,GGA2,TBC1D15,TBC1D24,TSC1,ARF6,RAB33B,SYTL1,TBC1D10A,TBC1D7,GABARAP,TBC1D20,RAB5A,OPTN,TSC2,GABARAPL2,RAB11A,TBC1D14,GGA3,TBC1D13,MIR4750,RAB5C,RABGEF1,RAB8A,RAB8B,TBC1D10B,RAB5B,GPR21,RAB7A,RAB6B,TBC1D2,ULK1,MAP1LC3B,RAB35,RABEP1
R-HSA-379724	tRNA Aminoacylation	0.528104883640156	-0.638460371744964	45	40	0.00442771751162276	9034	10285	57176,2617,51067,55699,10352,10667,4677,79587,5917,3376,1615,2058,6897,7453,54938,7965,80222,16,23395,7407,4141,57505,92935,51520,124454,25973,27068,3735,9521,2193,57038,5464,833,6301,8565,23438,9255,79731,5859,10056	VARS2,GARS1,YARS2,IARS2,WARS2,FARS2,NARS1,CARS2,RARS1,IARS1,DARS1,EPRS1,TARS1,WARS1,SARS2,AIMP2,TARS2,AARS1,LARS2,VARS1,MARS1,AARS2,MARS2,LARS1,EARS2,PARS2,PPA2,KARS1,EEF1E1,FARSA,RARS2,PPA1,CARS1,SARS1,YARS1,HARS2,AIMP1,NARS2,QARS1,FARSB
R-HSA-204005	COPII (Coat Protein 2) Mediated Vesicle Transport	0.534317400857009	-0.626765232970568	69	61	0.00675226920522471	9034	10285	122553,5265,10484,7039,11196,10959,1075,1453,2890,58485,89866,254263,9554,79748,27095,6811,1294,22872,966,5537,3998,63908,55291,10175,149111,55014,4905,128637,10427,9632,2348,10113,374,100313843,9871,10342,83696,10652,10282,23256,5861,10972,2153,10960,51128,51693,1522,2801,9117,6396,64689,26984,10802,23243,8774,81876,90411,9570,7109,79090,8615	TRAPPC6B,SERPINA1,SEC23A,TGFA,SEC23IP,TMED2,CTSC,CSNK1D,GRIA1,TRAPPC1,SEC16B,CNIH2,SEC22B,LMAN1L,TRAPPC3,STX5,COL7A1,SEC31A,CD59,PPP6C,LMAN1,NAPB,PPP6R3,CNIH1,CNIH3,STX17,NSF,TBC1D20,SEC24B,SEC24C,FOLR1,PREB,AREG,MIR711,SEC24D,TFG,TRAPPC9,YKT6,BET1,SCFD1,RAB1A,TMED10,F5,LMAN2,SAR1B,TRAPPC2L,CTSZ,GOLGA2,SEC22C,SEC13,GORASP1,SEC22A,SEC24A,ANKRD28,NAPG,RAB1B,MCFD2,GOSR2,TRAPPC10,TRAPPC6A,USO1
R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	0.534317400857009	-0.626765232970568	69	61	0.00675226920522471	9034	10285	8360,8343,8970,8339,27343,8340,4361,165918,8363,10111,7336,7518,27434,121504,8366,51567,10524,7158,51588,8348,8346,5591,8368,3017,8367,9025,8365,3018,8370,8341,8345,9577,8347,8361,7520,8362,580,22976,672,128312,79840,8924,8349,64421,55775,51720,7341,7334,84142,9656,3981,472,29086,8344,7468,8364,4683,8359,8290,55183,2547	H4C4,H2BC7,H2BC11,H2BC8,POLL,H2BC13,MRE11,RNF168,H4C11,RAD50,UBE2V2,XRCC4,POLM,H4C16,H4C2,TDP2,KAT5,TP53BP1,PIAS4,H2BC17,H2BC10,PRKDC,H4C13,H2BC5,H4C5,RNF8,H4C8,H2BC3,H4C14,H2BC15,H2BC9,BABAM2,H2BC4,H4C6,XRCC5,H4C12,BARD1,PAXIP1,BRCA1,H2BC26,NHEJ1,HERC2,H2BC21,DCLRE1C,TDP1,UIMC1,SUMO1,UBE2N,ABRAXAS1,MDC1,LIG4,ATM,BABAM1,H2BC6,NSD2,H4C3,NBN,H4C1,H3-4,RIF1,XRCC6
R-HSA-69304	Regulation of DNA replication	0.53617734918789	-0.623290297287971	77	68	0.00752711976975869	9034	10285	5702,5686,5690,5693,1870,5685,5719,4999,23595,51343,81620,5687,7314,4175,5000,4171,5720,8900,10213,5696,5001,5698,990,4173,5704,1026,1871,5695,84515,890,5691,5714,1027,9491,10197,5700,5692,5699,7311,4174,1017,5684,122706,143471,5710,23594,55388,7979,7316,23198,5713,5717,5706,5715,5682,4172,5694,9861,5708,5711,5707,6233,5718,4998,51053,5925,5701,1869	PSMC3,PSMA5,PSMB2,PSMB5,E2F2,PSMA4,PSMD13,ORC2,ORC3,FZR1,CDT1,PSMA6,UBB,MCM6,ORC4,MCM2,PSME1,CCNA1,PSMD14,PSMB8,ORC5,PSMB9,CDC6,MCM4,PSMC4,CDKN1A,E2F3,PSMB7,MCM8,CCNA2,PSMB3,PSMD8,CDKN1B,PSMF1,PSME3,PSMC1,PSMB4,PSMB10,UBA52,MCM5,CDK2,PSMA3,PSMB11,PSMA8,PSMD4,ORC6,MCM10,SEM1,UBC,PSME4,PSMD7,PSMD11,PSMC6,PSMD9,PSMA1,MCM3,PSMB6,PSMD6,PSMD2,PSMD5,PSMD1,RPS27A,PSMD12,ORC1,GMNN,RB1,PSMC2,E2F1
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	0.537953468742375	-0.619983211887211	85	75	0.00830197033429267	9034	10285	6118,2072,10987,902,7336,5985,8607,5886,6233,5981,7507,5111,5427,60,56655,85015,5887,7508,283899,7515,93973,6117,9557,9978,7316,50813,8451,1022,54107,7329,5983,7311,6613,404672,1643,10714,9318,125476,2067,3980,7334,3978,2073,79913,51138,142,4331,5424,54891,7341,5984,2068,54778,86,10920,10038,7314,54617,2873,10445,2968,4798,6119,8554,2967,1642,64708,2965,6612,7528,57804,5982,51426,2071,8533	RPA2,ERCC4,COPS5,CCNH,UBE2V2,RFC5,RUVBL1,RAD23A,RPS27A,RFC1,XPA,PCNA,POLE2,ACTB,POLE4,USP45,RAD23B,XPC,INO80E,XRCC1,ACTR8,RPA1,CHD1L,RBX1,UBC,COPS7A,CUL4A,CDK7,POLE3,UBE2I,RFC3,UBA52,SUMO2,GTF2H5,DDB2,POLD3,COPS2,INO80C,ERCC1,LIG3,UBE2N,LIG1,ERCC5,ACTR5,COPS4,PARP1,MNAT1,POLD1,INO80D,SUMO1,RFC4,ERCC2,RNF111,ACTL6A,COPS8,PARP2,UBB,INO80,GPS1,MCRS1,GTF2H4,NFRKB,RPA3,PIAS1,GTF2H3,DDB1,COPS7B,GTF2H1,SUMO3,YY1,POLD4,RFC2,POLK,ERCC3,COPS3
R-HSA-3781865	Diseases of glycosylation	0.537953468742375	-0.619983211887211	85	75	0.00830197033429267	9034	10285	2262,1605,9508,7058,11095,9037,394263,57188,339366,9719,5549,11096,118430,727897,94025,11173,54507,3339,9507,7057,11174,6382,4969,200958,4589,10082,11081,1463,54437,4854,171019,170691,170690,221981,81792,9510,170689,10675,4588,56999,1464,140766,4853,4060,6385,10417,170692,80070,9672,4585,10418,176,140453,55901,63827,92949,1462,143662,375790,79875,4583,157869,6383,56667,9509,1634,23145,4855,80731,10071,2331,2817,11093,81794,4958	GPC5,DAG1,ADAMTS3,THBS2,ADAMTS8,SEMA5A,MUC21,ADAMTSL3,ADAMTSL5,ADAMTSL2,PRELP,ADAMTS5,MUCL1,MUC5B,MUC16,ADAMTS7,ADAMTSL4,HSPG2,ADAMTS4,THBS1,ADAMTS6,SDC1,OGN,MUC20,MUC7,GPC6,KERA,NCAN,SEMA5B,NOTCH3,ADAMTS19,ADAMTS17,ADAMTS16,THSD7A,ADAMTS12,ADAMTS1,ADAMTS15,CSPG5,MUC6,ADAMTS9,CSPG4,ADAMTS14,NOTCH2,LUM,SDC4,SPON2,ADAMTS18,ADAMTS20,SDC3,MUC4,SPON1,ACAN,MUC17,THSD1,BCAN,ADAMTSL1,VCAN,MUC15,AGRN,THSD4,MUC2,SBSPON,SDC2,MUC13,ADAMTS2,DCN,SSPOP,NOTCH4,THSD7B,MUC12,FMOD,GPC1,ADAMTS13,ADAMTS10,OMD
R-HSA-1236975	Antigen processing-Cross presentation	0.541292206931346	-0.613796022232138	101	89	0.00985167146336064	9034	10285	122706,5692,10197,9491,23198,4615,7979,7316,6891,23480,5710,653361,143471,5708,9861,1515,3685,1147,5717,5682,5715,5701,10952,3134,7096,5690,8673,8773,5686,567,7097,3133,5685,5687,5704,5696,5695,5684,50489,5699,10333,1535,7311,5700,948,9341,4689,811,5713,4360,7099,5711,5694,6890,5706,5718,3693,23643,2209,4012,6233,9902,55176,5707,3106,5693,9554,5702,3105,3107,929,7314,5719,5698,3135,10213,1520,6892,2210,114609,5720,3551,5714,1514,3136,5691,29927,6810,4688	PSMB11,PSMB4,PSME3,PSMF1,PSME4,MYD88,SEM1,UBC,TAP2,SEC61G,PSMD4,NCF1,PSMA8,PSMD2,PSMD6,CTSV,ITGAV,CHUK,PSMD11,PSMA1,PSMD9,PSMC2,SEC61B,HLA-F,TLR1,PSMB2,VAMP8,SNAP23,PSMA5,B2M,TLR2,HLA-E,PSMA4,PSMA6,PSMC4,PSMB8,PSMB7,PSMA3,CD207,PSMB10,TLR6,CYBA,UBA52,PSMC1,CD36,VAMP3,NCF4,CALR,PSMD7,MRC1,TLR4,PSMD5,PSMB6,TAP1,PSMC6,PSMD12,ITGB5,LY96,FCGR1A,LNPEP,RPS27A,MRC2,SEC61A2,PSMD1,HLA-B,PSMB5,SEC22B,PSMC3,HLA-A,HLA-C,CD14,UBB,PSMD13,PSMB9,HLA-G,PSMD14,CTSS,TAPBP,FCGR1BP,TIRAP,PSME1,IKBKB,PSMD8,CTSL,HLA-H,PSMB3,SEC61A1,STX4,NCF2
R-HSA-5607764	CLEC7A (Dectin-1) signaling	0.541292206931346	-0.613796022232138	101	89	0.00985167146336064	9034	10285	5719,7314,4791,5702,8915,5693,3553,4773,5691,3551,5714,10892,5720,10213,6714,5698,5971,5580,5713,5700,5699,7311,84433,7322,5684,805,5707,6885,9039,6233,5718,5706,7335,5694,5534,5711,5685,5687,5170,3708,801,8454,5530,5686,5690,7189,5336,10454,4775,7334,7321,5695,4790,3710,23118,841,5696,6500,5704,29108,5710,143471,7316,7979,23198,10197,5532,9491,5692,122706,3709,23291,10768,64581,4772,4792,5701,1147,5717,5682,5715,9020,6850,997,9861,808,5708,8945,5970	PSMD13,UBB,NFKB2,PSMC3,BCL10,PSMB5,IL1B,NFATC2,PSMB3,IKBKB,PSMD8,MALT1,PSME1,PSMD14,SRC,PSMB9,RELB,PRKCD,PSMD7,PSMC1,PSMB10,UBA52,CARD11,UBE2D2,PSMA3,CALM2,PSMD1,MAP3K7,UBA3,RPS27A,PSMD12,PSMC6,UBE2V1,PSMB6,PPP3R1,PSMD5,PSMA4,PSMA6,PDPK1,ITPR1,CALM1,CUL1,PPP3CA,PSMA5,PSMB2,TRAF6,PLCG2,TAB1,NFATC3,UBE2N,UBE2D1,PSMB7,NFKB1,ITPR3,TAB2,CASP8,PSMB8,SKP1,PSMC4,PYCARD,PSMD4,PSMA8,UBC,SEM1,PSME4,PSME3,PPP3CB,PSMF1,PSMB4,PSMB11,ITPR2,FBXW11,AHCYL1,CLEC7A,NFATC1,NFKBIA,PSMC2,CHUK,PSMD11,PSMA1,PSMD9,MAP3K14,SYK,CDC34,PSMD6,CALM3,PSMD2,BTRC,RELA
R-HSA-69239	Synthesis of DNA	0.541292206931346	-0.613796022232138	101	89	0.00985167146336064	9034	10285	5558,5713,5684,4174,5699,7311,5983,5700,4998,5718,6118,5925,5111,5981,6233,5707,5711,5694,5706,4171,7314,23595,4999,5719,6119,51343,57804,5693,5702,1027,5714,5691,3978,5424,8318,1026,990,5698,4173,10213,5001,5984,5720,23198,7316,7979,23594,5710,143471,54107,1017,1763,122706,5692,10197,5557,9491,5701,5985,5427,84296,5708,56655,9861,4172,23649,5717,5682,6117,5715,51659,5000,4175,5685,81620,5687,5982,5690,5686,64785,10714,84515,890,2237,5695,5704,5696,8900,9837	PRIM2,PSMD7,PSMA3,MCM5,PSMB10,UBA52,RFC3,PSMC1,ORC1,PSMD12,RPA2,RB1,PCNA,RFC1,RPS27A,PSMD1,PSMD5,PSMB6,PSMC6,MCM2,UBB,ORC3,ORC2,PSMD13,RPA3,FZR1,POLD4,PSMB5,PSMC3,CDKN1B,PSMD8,PSMB3,LIG1,POLD1,CDC45,CDKN1A,CDC6,PSMB9,MCM4,PSMD14,ORC5,RFC4,PSME1,PSME4,UBC,SEM1,ORC6,PSMD4,PSMA8,POLE3,CDK2,DNA2,PSMB11,PSMB4,PSME3,PRIM1,PSMF1,PSMC2,RFC5,POLE2,GINS4,PSMD2,POLE4,PSMD6,MCM3,POLA2,PSMD11,PSMA1,RPA1,PSMD9,GINS2,ORC4,MCM6,PSMA4,CDT1,PSMA6,RFC2,PSMB2,PSMA5,GINS3,POLD3,MCM8,CCNA2,FEN1,PSMB7,PSMC4,PSMB8,CCNA1,GINS1
R-HSA-69306	DNA Replication	0.542870005874052	-0.610885387572547	109	96	0.0106265220278946	9034	10285	5702,5693,57804,5719,23595,4999,6119,51343,7314,4171,5720,10213,5001,5984,990,5698,4173,5424,1026,8318,3978,1871,5691,1027,5714,5700,5699,5983,7311,4174,5684,55388,5558,5713,5706,5694,5711,5707,5111,6233,5981,5718,4998,1869,6118,5925,5686,5690,5982,1870,10926,5685,81620,5687,4175,5000,51659,8900,9837,5696,5704,8317,2237,5695,84515,890,64785,10714,10197,5557,9491,5692,54107,1017,1763,122706,5710,143471,23594,7979,7316,23198,5717,23649,5682,5715,6117,4172,9861,56655,84296,5708,5427,5985,51053,5701	PSMC3,PSMB5,POLD4,PSMD13,ORC3,ORC2,RPA3,FZR1,UBB,MCM2,PSME1,PSMD14,ORC5,RFC4,CDC6,PSMB9,MCM4,POLD1,CDKN1A,CDC45,LIG1,E2F3,PSMB3,CDKN1B,PSMD8,PSMC1,PSMB10,RFC3,UBA52,MCM5,PSMA3,MCM10,PRIM2,PSMD7,PSMC6,PSMB6,PSMD5,PSMD1,PCNA,RPS27A,RFC1,PSMD12,ORC1,E2F1,RPA2,RB1,PSMA5,PSMB2,RFC2,E2F2,DBF4,PSMA4,CDT1,PSMA6,MCM6,ORC4,GINS2,CCNA1,GINS1,PSMB8,PSMC4,CDC7,FEN1,PSMB7,MCM8,CCNA2,GINS3,POLD3,PSME3,PRIM1,PSMF1,PSMB4,POLE3,CDK2,DNA2,PSMB11,PSMD4,PSMA8,ORC6,SEM1,UBC,PSME4,PSMD11,POLA2,PSMA1,PSMD9,RPA1,MCM3,PSMD6,POLE4,GINS4,PSMD2,POLE2,RFC5,GMNN,PSMC2
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	0.550517008102755	-0.596897427560508	44	39	0.00431702457383219	9034	10285	51692,4927,55339,79023,9883,8021,81608,81929,9631,10482,8086,11097,55706,9688,10189,4928,7175,129401,9818,53981,10762,100101267,23636,23165,5903,348995,23511,1977,22916,23279,53371,79902,8189,23225,9972,10898,55746,4686,57122	CPSF3,NUP88,WDR33,NUP37,POM121,NUP214,FIP1L1,SEH1L,NUP155,NXF1,AAAS,NUP42,NDC1,NUP93,ALYREF,NUP98,TPR,NUP35,NUP58,CPSF2,NUP50,POM121C,NUP62,NUP205,RANBP2,NUP43,NUP188,EIF4E,NCBP2,NUP160,NUP54,NUP85,SYMPK,NUP210,NUP153,CPSF4,NUP133,NCBP1,NUP107
R-HSA-975634	Retinoid metabolism and transport	0.550517008102755	-0.596897427560508	44	39	0.00431702457383219	9034	10285	51109,345,1208,4023,5406,55937,336,2262,7276,8644,9672,338328,57016,3339,9227,338,26020,6385,53630,29967,10082,5950,1109,6383,348,5947,375790,6382,3949,7804,4035,2817,1645,5948,4036,335,151056,344,337	RDH11,APOC3,CLPS,LPL,PNLIP,APOM,APOA2,GPC5,TTR,AKR1C3,SDC3,GPIHBP1,AKR1B10,HSPG2,LRAT,APOB,LRP10,SDC4,BCO1,LRP12,GPC6,RBP4,AKR1C4,SDC2,APOE,RBP1,AGRN,SDC1,LDLR,LRP8,LRP1,GPC1,AKR1C1,RBP2,LRP2,APOA1,PLB1,APOC2,APOA4
R-HSA-445355	Smooth Muscle Contraction	0.55053852173333	-0.596858349366912	36	32	0.00354217400929821	9034	10285	800,805,72,93408,140465,59,801,5829,7169,4629,25802,103910,302,7171,7170,7414,4636,10398,808,4638,10627,859,10174,8291,301,4637,3693,3672,7168,58498,309,10580	CALD1,CALM2,ACTG2,MYL10,MYL6B,ACTA2,CALM1,PXN,TPM2,MYH11,LMOD1,MYL12B,ANXA2,TPM4,TPM3,VCL,MYL5,MYL9,CALM3,MYLK,MYL12A,CAV3,SORBS3,DYSF,ANXA1,MYL6,ITGB5,ITGA1,TPM1,MYL7,ANXA6,SORBS1
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	0.55053852173333	-0.596858349366912	36	32	0.00354217400929821	9034	10285	5589,9761,7314,821,6048,811,7844,7316,79139,7311,5700,84447,10299,7841,7415,55741,6233,51035,55757,91445,10956,23193,6400,267,55768,11236,64772,56886,10206,9695,5887,80267	PRKCSH,MLEC,UBB,CANX,RNF5,CALR,RNF103,UBC,DERL1,UBA52,PSMC1,SYVN1,MARCHF6,MOGS,VCP,EDEM2,RPS27A,UBXN1,UGGT2,RNF185,OS9,GANAB,SEL1L,AMFR,NGLY1,RNF139,ENGASE,UGGT1,TRIM13,EDEM1,RAD23B,EDEM3
R-HSA-190828	Gap junction trafficking	0.55135918211069	-0.595368809047094	28	25	0.00276732344476422	9034	10285	2697,219770,57369,2707,125111,57165,2701,2706,1211,1601,127534,84694,10052,1759,1212,1213,1785,1173,8218,2702,4646,2700,2709,10804,2703	GJA1,GJD4,GJD2,GJB3,GJD3,GJC2,GJA4,GJB2,CLTA,DAB2,GJB4,GJA10,GJC1,DNM1,CLTB,CLTC,DNM2,AP2M1,CLTCL1,GJA5,MYO6,GJA3,GJB5,GJB6,GJA8
R-HSA-70268	Pyruvate metabolism	0.55135918211069	-0.595368809047094	28	25	0.00276732344476422	9034	10285	3945,8050,2739,682,160287,5164,92483,3029,54704,3948,5166,57546,55066,1737,23539,51660,6566,5163,5467,9123,6256,1738,3939,25874,5162	LDHB,PDHX,GLO1,BSG,LDHAL6A,PDK2,LDHAL6B,HAGH,PDP1,LDHC,PDK4,PDP2,PDPR,DLAT,SLC16A8,MPC1,SLC16A1,PDK1,PPARD,SLC16A3,RXRA,DLD,LDHA,MPC2,PDHB
R-HSA-5576893	Phase 2 - plateau phase	0.55135918211069	-0.595368809047094	28	25	0.00276732344476422	9034	10285	783,9254,786,779,784,93589,775,55799,9992,59283,3784,10142,10369,3753,781,10368,59285,27092,27091,59284,785,100126325,23704,776,10008	CACNB2,CACNA2D2,CACNG1,CACNA1S,CACNB3,CACNA2D4,CACNA1C,CACNA2D3,KCNE2,CACNG8,KCNQ1,AKAP9,CACNG2,KCNE1,CACNA2D1,CACNG3,CACNG6,CACNG4,CACNG5,CACNG7,CACNB4,MIR935,KCNE4,CACNA1D,KCNE3
R-HSA-381771	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	0.55391167966481	-0.590750027931757	20	18	0.00199247288023024	9034	10285	2784,90701,6934,338557,2922,1803,2641,1045,2864,23478,5080,3952,5122,9789,51764,1499,346562,60559	GNB3,SEC11C,TCF7L2,FFAR4,GRP,DPP4,GCG,CDX2,FFAR1,SEC11A,PAX6,LEP,PCSK1,SPCS2,GNG13,CTNNB1,GNAT3,SPCS3
R-HSA-5654720	PI-3K cascade:FGFR4	0.55391167966481	-0.590750027931757	20	18	0.00199247288023024	9034	10285	8817,5290,8822,9965,2254,2253,8074,5781,2247,10818,5295,26281,2251,2246,2549,2249,2885,2264	FGF18,PIK3CA,FGF17,FGF19,FGF9,FGF8,FGF23,PTPN11,FGF2,FRS2,PIK3R1,FGF20,FGF6,FGF1,GAB1,FGF4,GRB2,FGFR4
R-HSA-69186	Lagging Strand Synthesis	0.55391167966481	-0.590750027931757	20	18	0.00199247288023024	9034	10285	5985,5558,6118,10714,3978,6119,2237,5111,5981,5982,57804,5424,1763,23649,5557,6117,5983,5984	RFC5,PRIM2,RPA2,POLD3,LIG1,RPA3,FEN1,PCNA,RFC1,RFC2,POLD4,POLD1,DNA2,POLA2,PRIM1,RPA1,RFC3,RFC4
R-HSA-5654719	SHC-mediated cascade:FGFR4	0.55391167966481	-0.590750027931757	20	18	0.00199247288023024	9034	10285	8822,6654,8817,9965,2247,2254,2253,8074,6464,3845,26281,3265,2246,2249,2251,2264,4893,2885	FGF17,SOS1,FGF18,FGF19,FGF2,FGF9,FGF8,FGF23,SHC1,KRAS,FGF20,HRAS,FGF1,FGF4,FGF6,FGFR4,NRAS,GRB2
R-HSA-879518	Transport of organic anions	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	551,6579,28234,353189,10599,11309,28231,28232,53919,6578,213	AVP,SLCO1A2,SLCO1B3,SLCO4C1,SLCO1B1,SLCO2B1,SLCO4A1,SLCO3A1,SLCO1C1,SLCO2A1,ALB
R-HSA-176974	Unwinding of DNA	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	9837,4175,4172,4171,4173,4174,84515,8318,84296,64785,51659	GINS1,MCM6,MCM3,MCM2,MCM4,MCM5,MCM8,CDC45,GINS4,GINS3,GINS2
R-HSA-5689877	Josephin domain DUBs	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	7415,6233,7314,9929,5886,7316,4287,126119,7311,5071,5887	VCP,RPS27A,UBB,JOSD1,RAD23A,UBC,ATXN3,JOSD2,UBA52,PRKN,RAD23B
R-HSA-211979	Eicosanoids	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	1582,1580,57834,1579,6916,8529,5740,284541,126410,11283,66002	CYP8B1,CYP4B1,CYP4F11,CYP4A11,TBXAS1,CYP4F2,PTGIS,CYP4A22,CYP4F22,CYP4F8,CYP4F12
R-HSA-166786	Creation of C4 and C2 activators	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	10747,1401,714,4153,715,5648,712,2219,713,2220,716	MASP2,CRP,C1QC,MBL2,C1R,MASP1,C1QA,FCN1,C1QB,FCN2,C1S
R-HSA-389359	CD28 dependent Vav1 pathway	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	940,942,998,2885,5062,3932,2534,5058,941,7409,5879	CD28,CD86,CDC42,GRB2,PAK2,LCK,FYN,PAK1,CD80,VAV1,RAC1
R-HSA-1433617	Regulation of signaling by NODAL	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	92,9350,6997,130399,199699,91,10637,93,55997,7044,4838	ACVR2A,CER1,CRIPTO,ACVR1C,DAND5,ACVR1B,LEFTY1,ACVR2B,CFC1,LEFTY2,NODAL
R-HSA-390666	Serotonin receptors	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	3363,3351,3355,3357,3360,3362,3361,3354,3356,3350,3352	HTR7,HTR1B,HTR1F,HTR2B,HTR4,HTR6,HTR5A,HTR1E,HTR2A,HTR1A,HTR1D
R-HSA-1475029	Reversible hydration of carbon dioxide	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	765,762,760,23632,768,763,761,759,771,766,377677	CA6,CA4,CA2,CA14,CA9,CA5A,CA3,CA1,CA12,CA7,CA13
R-HSA-451308	Activation of Ca-permeable Kainate Receptor	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	2898,2901,801,2899,1739,805,808,2897,83988,2900,1742	GRIK2,GRIK5,CALM1,GRIK3,DLG1,CALM2,CALM3,GRIK1,NCALD,GRIK4,DLG4
R-HSA-2022857	Keratan sulfate degradation	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	4958,176,2331,4060,79411,5549,11081,4969,2799,3074,2720	OMD,ACAN,FMOD,LUM,GLB1L,PRELP,KERA,OGN,GNS,HEXB,GLB1
R-HSA-203615	eNOS activation	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	808,23576,340481,805,3320,857,207,4846,801,10434,114757	CALM3,DDAH1,ZDHHC21,CALM2,HSP90AA1,CAV1,AKT1,NOS3,CALM1,LYPLA1,CYGB
R-HSA-211958	Miscellaneous substrates	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	284541,29785,8529,54905,1579,57834,126410,113612,64816,1580,1565	CYP4A22,CYP2S1,CYP4F2,CYP2W1,CYP4A11,CYP4F11,CYP4F22,CYP2U1,CYP3A43,CYP4B1,CYP2D6
R-HSA-1839130	Signaling by activated point mutants of FGFR3	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	2246,2249,2247,2253,2254,8074,2261,8822,8817,26281,2250	FGF1,FGF4,FGF2,FGF8,FGF9,FGF23,FGFR3,FGF17,FGF18,FGF20,FGF5
R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	2643,1719,207,808,801,6697,3320,5593,5805,4846,805	GCH1,DHFR,AKT1,CALM3,CALM1,SPR,HSP90AA1,PRKG2,PTS,NOS3,CALM2
R-HSA-2160916	Hyaluronan uptake and degradation	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	10894,3074,11261,3161,3373,8372,960,55576,6548,8692,2990	LYVE1,HEXB,CHP1,HMMR,HYAL1,HYAL3,CD44,STAB2,SLC9A1,HYAL2,GUSB
R-HSA-190373	FGFR1c ligand binding and activation	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	2250,8822,2247,8074,2254,2253,26281,2260,2246,2249,2251	FGF5,FGF17,FGF2,FGF23,FGF9,FGF8,FGF20,FGFR1,FGF1,FGF4,FGF6
R-HSA-451306	Ionotropic activity of Kainate Receptors	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	1739,805,83988,1742,2900,808,2897,2901,2898,801,2899	DLG1,CALM2,NCALD,DLG4,GRIK4,CALM3,GRIK1,GRIK5,GRIK2,CALM1,GRIK3
R-HSA-2033514	FGFR3 mutant receptor activation	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	2246,2249,26281,2247,2254,2253,8074,2261,8822,8817,2250	FGF1,FGF4,FGF20,FGF2,FGF9,FGF8,FGF23,FGFR3,FGF17,FGF18,FGF5
R-HSA-73621	Pyrimidine catabolism	0.561327630330598	-0.577450532643175	12	11	0.00121762231569626	9034	10285	64902,84618,30833,151531,1807,4907,51251,51733,56953,7378,1806	AGXT2,NT5C1A,NT5C,UPP2,DPYS,NT5E,NT5C3A,UPB1,NT5M,UPP1,DPYD
R-HSA-2559583	Cellular Senescence	0.568191022288337	-0.565297609953794	196	172	0.0190391852999779	9034	10285	1911,5601,8360,1031,5928,8343,4361,3018,8367,7295,8341,996,7157,5598,8353,3007,192669,1017,7029,8334,1029,25842,5599,23112,4790,8354,3159,57332,57634,1051,9134,23043,8344,7867,26277,8726,3020,64682,25906,6774,6233,1869,5606,65057,3725,2146,8970,8355,898,8345,51529,3008,192670,4217,8346,3017,8368,1871,55766,1019,7027,1027,51433,8697,6015,22955,3009,8352,8335,51343,1032,4001,472,5602,2077,29945,1912,3013,29855,84733,3569,8358,653604,8968,7324,7290,11065,8339,5970,5608,10111,126961,8365,8370,7316,3005,23466,8366,121504,8348,3552,80012,10524,6045,3006,7321,26523,1021,6195,3456,890,8362,128312,8900,6196,8349,27327,8359,5594,8290,6667,57690,5609,9261,23135,1870,7013,100500853,5925,3024,8357,23512,9448,23523,8340,8363,8091,4343,8350,94239,8347,1030,8361,5600,648,7311,5595,2114,4194,3015,3021,2353,25913,8535,50488,3012,1432,2113,3576,1026,4193,7314,3490,7014,10919,4683,119504,723790,51434,6416,8364,10393	PHC1,MAPK9,H4C4,CDKN2C,RBBP4,H2BC7,MRE11,H2BC3,H4C5,TXN,H2BC15,CDC27,TP53,MAPK7,H3C6,H1-3,AGO3,CDK2,TFDP2,H2AC6,CDKN2A,ASF1A,MAPK8,TNRC6B,NFKB1,H3C11,HMGA1,CBX8,EP400,CEBPB,CCNE2,TNIK,H2BC6,MAPKAPK3,TINF2,EED,H3-3A,ANAPC1,ANAPC15,STAT3,RPS27A,E2F1,MAP2K3,ACD,JUN,EZH2,H2BC11,H3C8,CCNE1,H2BC9,ANAPC11,H1-4,AGO4,MAP3K5,H2BC10,H2BC5,H4C13,E2F3,H2AJ,CDK4,TFDP1,CDKN1B,ANAPC5,CDC23,RING1,SCMH1,H1-5,H3C3,H2AC4,FZR1,CDKN2D,LMNB1,ATM,MAPK10,ERF,ANAPC4,PHC2,H2AC7,UBN1,CBX2,IL6,H3C2,H3C13,H3C7,UBE2E1,HIRA,UBE2C,H2BC8,RELA,MAP2K6,RAD50,H3C14,H4C8,H4C14,UBC,H1-0,CBX6,H4C2,H4C16,H2BC17,IL1A,PHC3,KAT5,RNF2,H1-2,UBE2D1,AGO1,CDK6,RPS6KA1,IFNB1,CCNA2,H4C12,H2BC26,CCNA1,RPS6KA2,H2BC21,TNRC6A,H4C1,MAPK1,H3-4,SP1,TNRC6C,MAP2K7,MAPKAPK2,KDM6B,E2F2,TERF1,MIR3605,RB1,H1-1,H3C10,SUZ12,MAP4K4,CABIN1,H2BC13,H4C11,HMGA2,MOV10,H3C1,H2AZ2,H2BC4,CDKN2B,H4C6,MAPK11,BMI1,UBA52,MAPK3,ETS2,MDM4,H2AZ1,H3-3B,FOS,POT1,CBX4,MINK1,H2AC8,MAPK14,ETS1,CXCL8,CDKN1A,MDM2,UBB,IGFBP7,TERF2,EHMT2,NBN,ANAPC16,H2AC19,ANAPC7,MAP2K4,H4C3,ANAPC10
R-HSA-195253	Degradation of beta-catenin by the destruction complex	0.570471654237382	-0.561291796738434	83	73	0.00808058445871153	9034	10285	5519,5525,83439,5715,5682,5527,5717,5706,5694,6934,9861,5711,8945,5708,5707,5526,6233,5701,5528,5718,8312,9491,10197,5700,7311,6932,324,5692,5699,7089,122706,5684,143471,5710,1452,1499,7316,7979,5713,23198,9978,166,5720,10213,5696,7088,6500,5698,5704,3065,7090,5695,5691,2932,10023,5714,5516,5686,1487,5702,8454,5690,5693,5518,5687,7091,5529,5685,5515,5719,7314,51176,1488	PPP2R1B,PPP2R5A,TCF7L1,PSMD9,PSMA1,PPP2R5C,PSMD11,PSMC6,PSMB6,TCF7L2,PSMD6,PSMD5,BTRC,PSMD2,PSMD1,PPP2R5B,RPS27A,PSMC2,PPP2R5D,PSMD12,AXIN1,PSMF1,PSME3,PSMC1,UBA52,TCF7,APC,PSMB4,PSMB10,TLE2,PSMB11,PSMA3,PSMA8,PSMD4,CSNK1A1,CTNNB1,UBC,SEM1,PSMD7,PSME4,RBX1,TLE5,PSME1,PSMD14,PSMB8,TLE1,SKP1,PSMB9,PSMC4,HDAC1,TLE3,PSMB7,PSMB3,GSK3B,FRAT1,PSMD8,PPP2CB,PSMA5,CTBP1,PSMC3,CUL1,PSMB2,PSMB5,PPP2R1A,PSMA6,TLE4,PPP2R5E,PSMA4,PPP2CA,PSMD13,UBB,LEF1,CTBP2
R-HSA-69615	G1/S DNA Damage Checkpoints	0.570480308128835	-0.56127662714017	67	59	0.00653088332964357	9034	10285	9491,5700,10197,7311,5692,5699,4194,122706,1017,5684,143471,5710,7316,7979,5713,23198,7157,898,5715,5682,5717,5706,5694,9861,5711,5708,5707,6233,5701,5718,5686,5702,1111,472,5690,5693,5687,5685,5719,57060,7314,993,25946,9134,5720,8900,10213,5696,4193,5698,64326,5704,1026,5695,5691,890,5714,1027,11200	PSMF1,PSMC1,PSME3,UBA52,PSMB4,PSMB10,MDM4,PSMB11,CDK2,PSMA3,PSMA8,PSMD4,UBC,SEM1,PSMD7,PSME4,TP53,CCNE1,PSMD9,PSMA1,PSMD11,PSMC6,PSMB6,PSMD6,PSMD5,PSMD2,PSMD1,RPS27A,PSMC2,PSMD12,PSMA5,PSMC3,CHEK1,ATM,PSMB2,PSMB5,PSMA6,PSMA4,PSMD13,PCBP4,UBB,CDC25A,ZNF385A,CCNE2,PSME1,CCNA1,PSMD14,PSMB8,MDM2,PSMB9,COP1,PSMC4,CDKN1A,PSMB7,PSMB3,CCNA2,PSMD8,CDKN1B,CHEK2
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	0.570480308128835	-0.56127662714017	67	59	0.00653088332964357	9034	10285	5684,122706,64344,7322,5699,5692,7311,10197,5700,9491,9978,23198,5713,7316,7979,54583,6923,5710,143471,5708,5711,9861,6921,5694,5706,112399,8453,5717,5682,5715,5718,5701,6233,5707,8994,5693,7323,5690,5702,5686,7428,3091,7314,5719,5685,5687,126374,5704,5698,5696,10213,84962,2034,5720,5714,5691,7321,5695,112398	PSMA3,PSMB11,HIF3A,UBE2D2,PSMB10,PSMB4,UBA52,PSME3,PSMC1,PSMF1,RBX1,PSME4,PSMD7,UBC,SEM1,EGLN1,ELOB,PSMD4,PSMA8,PSMD2,PSMD5,PSMD6,ELOC,PSMB6,PSMC6,EGLN3,CUL2,PSMD11,PSMA1,PSMD9,PSMD12,PSMC2,RPS27A,PSMD1,LIMD1,PSMB5,UBE2D3,PSMB2,PSMC3,PSMA5,VHL,HIF1A,UBB,PSMD13,PSMA4,PSMA6,WTIP,PSMC4,PSMB9,PSMB8,PSMD14,AJUBA,EPAS1,PSME1,PSMD8,PSMB3,UBE2D1,PSMB7,EGLN2
R-HSA-112310	Neurotransmitter Release Cycle	0.5716869667919	-0.559163698257538	51	45	0.0049811822005756	9034	10285	10815,8497,6539,2572,6571,6540,6857,8224,6580,8541,27165,7915,6512,6812,10550,6616,8825,6507,6505,6582,6506,6854,6529,6511,80331,27163,57030,3312,8500,55327,320,60482,6844,22999,6538,2744,9256,10497,8499,140679,2571,18,5864,54407,1103	CPLX1,PPFIA4,SLC6A12,GAD2,SLC18A2,SLC6A13,SYT1,SYN3,SLC22A1,PPFIA3,GLS2,ALDH5A1,SLC1A7,STXBP1,ARL6IP5,SNAP25,LIN7A,SLC1A3,SLC1A1,SLC22A2,SLC1A2,SYN2,SLC6A1,SLC1A6,DNAJC5,NAAA,SLC17A7,HSPA8,PPFIA1,LIN7C,APBA1,SLC5A7,VAMP2,RIMS1,SLC6A11,GLS,TSPOAP1,UNC13B,PPFIA2,SLC32A1,GAD1,ABAT,RAB3A,SLC38A2,CHAT
R-HSA-168325	Viral Messenger RNA Synthesis	0.573131554214333	-0.556640000112115	43	38	0.00420633163604162	9034	10285	9883,8021,79023,4927,5440,7175,4928,129401,9818,5433,5430,8086,11097,5439,5432,55706,9688,81929,9631,23279,348995,5431,23511,100101267,23636,23165,5903,5441,10762,57122,55746,2962,5434,79902,23225,9972,2963,53371	POM121,NUP214,NUP37,NUP88,POLR2K,TPR,NUP98,NUP35,NUP58,POLR2D,POLR2A,AAAS,NUP42,POLR2J,POLR2C,NDC1,NUP93,SEH1L,NUP155,NUP160,NUP43,POLR2B,NUP188,POM121C,NUP62,NUP205,RANBP2,POLR2L,NUP50,NUP107,NUP133,GTF2F1,POLR2E,NUP85,NUP210,NUP153,GTF2F2,NUP54
R-HSA-5362517	Signaling by Retinoic Acid	0.573131554214333	-0.556640000112115	43	38	0.00420633163604162	9034	10285	126,51109,5166,157506,5915,1382,124,5164,2171,10901,1592,1374,8644,8854,5916,216,5914,8050,1738,6256,220,728635,5162,5959,195814,5163,8608,6258,56603,5467,112724,127,10170,57665,9249,1381,1737,64577	ADH1C,RDH11,PDK4,RDH10,RARB,CRABP2,ADH1A,PDK2,FABP5,DHRS4,CYP26A1,CPT1A,AKR1C3,ALDH1A2,RARG,ALDH1A1,RARA,PDHX,DLD,RXRA,ALDH1A3,DHRS4L1,PDHB,RDH5,SDR16C5,PDK1,RDH16,RXRG,CYP26B1,PPARD,RDH13,ADH4,DHRS9,RDH14,DHRS3,CRABP1,DLAT,ALDH8A1
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	0.573131554214333	-0.556640000112115	43	38	0.00420633163604162	9034	10285	7514,83595,56998,4221,6233,6934,6662,57680,6657,3065,8945,7090,83439,64321,7088,207,90780,283149,51176,7534,7316,607,6659,7091,55553,7314,1499,9580,7089,5929,208,1487,7311,9070,6932,324,25776,26108	XPO1,SOX7,CTNNBIP1,MEN1,RPS27A,TCF7L2,SOX9,CHD8,SOX2,HDAC1,BTRC,TLE3,TCF7L1,SOX17,TLE1,AKT1,PYGO2,BCL9L,LEF1,YWHAZ,UBC,BCL9,SOX4,TLE4,SOX6,UBB,CTNNB1,SOX13,TLE2,RBBP5,AKT2,CTBP1,UBA52,ASH2L,TCF7,APC,CBY1,PYGO1
R-HSA-5655253	Signaling by FGFR2 in disease	0.573131554214333	-0.556640000112115	43	38	0.00420633163604162	9034	10285	2549,2246,22916,5431,5295,5441,2248,3265,2247,8074,2253,4686,5434,2962,6654,2963,2250,2252,2249,2251,2263,2885,4893,10818,3845,26281,27006,2255,2254,5433,5335,5440,8822,8817,5290,5430,5439,5432	GAB1,FGF1,NCBP2,POLR2B,PIK3R1,POLR2L,FGF3,HRAS,FGF2,FGF23,FGF8,NCBP1,POLR2E,GTF2F1,SOS1,GTF2F2,FGF5,FGF7,FGF4,FGF6,FGFR2,GRB2,NRAS,FRS2,KRAS,FGF20,FGF22,FGF10,FGF9,POLR2D,PLCG1,POLR2K,FGF17,FGF18,PIK3CA,POLR2A,POLR2J,POLR2C
R-HSA-933541	TRAF6 mediated IRF7 activation	0.575599164130421	-0.552343756140894	35	31	0.00343148107150764	9034	10285	29110,7706,3441,3452,3445,4615,9641,3660,3444,100302237,2033,3448,64135,84282,7189,23586,3659,3456,3665,1387,170506,80143,3661,100500827,57506,3443,3439,10010,3442,3440,3449	TBK1,TRIM25,IFNA4,IFNA21,IFNA8,MYD88,IKBKE,IRF2,IFNA7,MIR1281,EP300,IFNA14,IFIH1,RNF135,TRAF6,RIGI,IRF1,IFNB1,IRF7,CREBBP,DHX36,SIKE1,IRF3,MIR3614,MAVS,IFNA6,IFNA1,TANK,IFNA5,IFNA2,IFNA16
R-HSA-977606	Regulation of Complement cascade	0.579880389954659	-0.544933420924914	27	24	0.00265663050697365	9034	10285	727,720,729,725,730,735,719,717,966,27202,731,4179,728,3075,100293534,1604,722,732,629,3426,718,5627,10878,1378	C5,C4A,C6,C4BPB,C7,C9,C3AR1,C2,CD59,C5AR2,C8A,CD46,C5AR1,CFH,C4B_2,CD55,C4BPA,C8B,CFB,CFI,C3,PROS1,CFHR3,CR1
R-HSA-1482788	Acyl chain remodelling of PC	0.579880389954659	-0.544933420924914	27	24	0.00265663050697365	9034	10285	123745,22925,30814,5321,283748,100137049,5319,26279,54947,50640,50487,10162,151056,8605,11145,8398,5322,255189,5320,64600,79888,81579,129642,79887	PLA2G4E,PLA2R1,PLA2G2E,PLA2G4A,PLA2G4D,PLA2G4B,PLA2G1B,PLA2G2D,LPCAT2,PNPLA8,PLA2G3,LPCAT3,PLB1,PLA2G4C,PLAAT3,PLA2G6,PLA2G5,PLA2G4F,PLA2G2A,PLA2G2F,LPCAT1,PLA2G12A,MBOAT2,PLBD1
R-HSA-202424	Downstream TCR signaling	0.58599729501665	-0.53444010542832	98	86	0.00951959264998893	9034	10285	5718,4792,5701,3127,5588,3119,6233,5707,23291,6885,5708,8945,5970,5711,997,7335,9861,5694,5706,5717,1147,5682,5715,23198,5713,7316,7979,920,5710,143471,5684,122706,84433,3120,7322,5699,5692,3123,7311,10197,5700,9491,3551,4790,5714,5691,7321,7334,3635,3113,5695,5296,5291,3932,5704,5698,916,6500,5696,10213,50852,5295,23118,10892,5720,919,917,915,5170,7314,3118,5685,5719,5687,5290,5728,8767,3122,7189,3117,5693,5690,8454,5702,8915,5686	PSMD12,NFKBIA,PSMC2,HLA-DRB5,PRKCQ,HLA-DQB1,RPS27A,PSMD1,FBXW11,MAP3K7,PSMD2,BTRC,RELA,PSMD5,CDC34,UBE2V1,PSMD6,PSMB6,PSMC6,PSMD11,CHUK,PSMA1,PSMD9,PSME4,PSMD7,UBC,SEM1,CD4,PSMD4,PSMA8,PSMA3,PSMB11,CARD11,HLA-DQB2,UBE2D2,PSMB10,PSMB4,HLA-DRB1,UBA52,PSME3,PSMC1,PSMF1,IKBKB,NFKB1,PSMD8,PSMB3,UBE2D1,UBE2N,INPP5D,HLA-DPA1,PSMB7,PIK3R2,PIK3CB,LCK,PSMC4,PSMB9,CD3E,SKP1,PSMB8,PSMD14,TRAT1,PIK3R1,TAB2,MALT1,PSME1,CD247,CD3G,CD3D,PDPK1,UBB,HLA-DQA2,PSMA4,PSMD13,PSMA6,PIK3CA,PTEN,RIPK2,HLA-DRA,TRAF6,HLA-DQA1,PSMB5,PSMB2,CUL1,PSMC3,BCL10,PSMA5
R-HSA-5687128	MAPK6/MAPK4 signaling	0.58628282031718	-0.533952977305202	90	79	0.00874474208545495	9034	10285	8202,10642,7314,5687,5685,5719,983,5693,5690,57690,2118,5686,5702,5879,5714,27161,23112,7514,5691,2309,4609,5695,26523,5704,5062,27327,5698,10213,5696,5720,5896,5713,23198,8556,192669,7316,7979,2308,8997,5596,143471,5710,4343,998,122706,896,8555,5897,5684,3315,7311,192670,5692,5699,5597,9491,10197,5700,5701,5718,989,6233,5058,5567,10435,10602,5707,5711,5708,3337,5694,5568,9861,5566,5715,5682,5717,5706,3725	NCOA3,IGF2BP1,UBB,PSMA6,PSMA4,PSMD13,CDK1,PSMB5,PSMB2,TNRC6C,ETV4,PSMA5,PSMC3,RAC1,PSMD8,AGO2,TNRC6B,XPO1,PSMB3,FOXO3,MYC,PSMB7,AGO1,PSMC4,PAK2,TNRC6A,PSMB9,PSMD14,PSMB8,PSME1,RAG1,PSMD7,PSME4,CDC14A,AGO3,UBC,SEM1,FOXO1,KALRN,MAPK4,PSMA8,PSMD4,MOV10,CDC42,PSMB11,CCND3,CDC14B,RAG2,PSMA3,HSPB1,UBA52,AGO4,PSMB4,PSMB10,MAPK6,PSMF1,PSME3,PSMC1,PSMC2,PSMD12,SEPTIN7,RPS27A,PAK1,PRKACB,CDC42EP2,CDC42EP3,PSMD1,PSMD5,PSMD2,DNAJB1,PSMB6,PRKACG,PSMD6,PRKACA,PSMD9,PSMA1,PSMD11,PSMC6,JUN
R-HSA-69300	Removal of licensing factors from origins	0.587531801202693	-0.53182490472207	74	65	0.00719504095638698	9034	10285	5708,5711,5694,9861,4172,5717,5706,5715,5682,4998,5718,51053,5701,5925,6233,5707,1017,5684,122706,4174,5692,5699,7311,9491,10197,5700,23198,5713,55388,7316,7979,23594,143471,5710,5704,1026,5698,990,4173,10213,5696,5001,5720,8900,5714,1027,84515,890,5691,5695,5693,5690,5702,5686,5000,4171,7314,4175,4999,23595,5719,5685,51343,5687,81620	PSMD2,PSMD5,PSMB6,PSMD6,MCM3,PSMD11,PSMC6,PSMD9,PSMA1,ORC1,PSMD12,GMNN,PSMC2,RB1,RPS27A,PSMD1,CDK2,PSMA3,PSMB11,MCM5,PSMB4,PSMB10,UBA52,PSMF1,PSME3,PSMC1,PSME4,PSMD7,MCM10,UBC,SEM1,ORC6,PSMA8,PSMD4,PSMC4,CDKN1A,PSMB9,CDC6,MCM4,PSMD14,PSMB8,ORC5,PSME1,CCNA1,PSMD8,CDKN1B,MCM8,CCNA2,PSMB3,PSMB7,PSMB5,PSMB2,PSMC3,PSMA5,ORC4,MCM2,UBB,MCM6,ORC2,ORC3,PSMD13,PSMA4,FZR1,PSMA6,CDT1
R-HSA-3928664	Ephrin signaling	0.587881048377198	-0.531230650226882	19	17	0.00188177994243967	9034	10285	2534,1948,2048,5062,2049,6386,2051,6714,1949,10627,5879,2050,8874,2047,8440,28964,5058	FYN,EFNB2,EPHB2,PAK2,EPHB3,SDCBP,EPHB6,SRC,EFNB3,MYL12A,RAC1,EPHB4,ARHGEF7,EPHB1,NCK2,GIT1,PAK1
R-HSA-416700	Other semaphorin interactions	0.587881048377198	-0.531230650226882	19	17	0.00188177994243967	9034	10285	5361,3672,971,64218,80031,9723,10507,57556,3688,7305,9037,91584,10154,5362,5788,23129,8482	PLXNA1,ITGA1,CD72,SEMA4A,SEMA6D,SEMA3E,SEMA4D,SEMA6A,ITGB1,TYROBP,SEMA5A,PLXNA4,PLXNC1,PLXNA2,PTPRC,PLXND1,SEMA7A
R-HSA-5223345	Miscellaneous transport and binding events	0.587881048377198	-0.531230650226882	19	17	0.00188177994243967	9034	10285	120,152519,118,5304,81614,348938,57185,119,79815,56172,57380,563,123606,2039,54896,1497,7991	ADD3,NIPAL1,ADD1,PIP,NIPA2,NIPAL4,NIPAL3,ADD2,NIPAL2,ANKH,MRS2,AZGP1,NIPA1,DMTN,SLC66A1,CTNS,TUSC3
R-HSA-73887	Death Receptor Signalling	0.592547330155461	-0.523324527044337	50	44	0.00487048926278503	9034	10285	7128,1147,8887,8717,6885,330,6233,329,8567,7185,6868,7311,10616,56957,8737,8772,6610,27005,25999,7316,8439,7132,23118,7124,55512,841,356,90268,8837,56928,1540,3551,8795,8797,8743,9099,843,10454,84888,7314,7375,355,9530,10399	TNFAIP3,CHUK,TAX1BP1,TRADD,MAP3K7,BIRC3,RPS27A,BIRC2,MADD,TRAF1,ADAM17,UBA52,RBCK1,OTUD7B,RIPK1,FADD,SMPD2,USP21,CLIP3,UBC,NSMAF,TNFRSF1A,TAB2,TNF,SMPD3,CASP8,FASLG,OTULIN,CFLAR,SPPL2B,CYLD,IKBKB,TNFRSF10B,TNFRSF10A,TNFSF10,USP2,CASP10,TAB1,SPPL2A,UBB,USP4,FAS,BAG4,RACK1
R-HSA-6802949	Signaling by RAS mutants	0.592547330155461	-0.523324527044337	50	44	0.00487048926278503	9034	10285	2335,8831,409,673,5921,8315,8826,283455,5605,3690,5604,7414,54518,8437,10156,2266,6714,7529,2244,3265,4140,100847012,3674,5037,64926,408,1445,10256,5245,5594,5894,3717,153090,7450,9462,4893,5906,4296,5922,5908,3845,5595,2243,4763	FN1,SYNGAP1,ARRB2,BRAF,RASA1,BRAP,IQGAP1,KSR2,MAP2K2,ITGB3,MAP2K1,VCL,APBB1IP,RASAL1,RASA4,FGG,SRC,YWHAB,FGB,HRAS,MARK3,MIR5004,ITGA2B,PEBP1,RASAL3,ARRB1,CSK,CNKSR1,PHB1,MAPK1,RAF1,JAK2,DAB2IP,VWF,RASAL2,NRAS,RAP1A,MAP3K11,RASA2,RAP1B,KRAS,MAPK3,FGA,NF1
R-HSA-1855191	Synthesis of IPs in the nucleus	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	51447,253430,64768,9807	IP6K2,IPMK,IPPK,IP6K1
R-HSA-165158	Activation of AKT2	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	208,5170,57761,117145	AKT2,PDPK1,TRIB3,THEM4
R-HSA-75944	Transcription from mitochondrial promoters	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	7019,5442,64216,7978	TFAM,POLRMT,TFB2M,MTERF1
R-HSA-1296053	Classical Kir channels	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	3759,3761,3770,3768	KCNJ2,KCNJ4,KCNJ14,KCNJ12
R-HSA-69200	Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	9134,5925,1017,898	CCNE2,RB1,CDK2,CCNE1
R-HSA-447115	Interleukin-12 signaling	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	3592,3595,3594,3593	IL12A,IL12RB2,IL12RB1,IL12B
R-HSA-69560	Transcriptional activation of p53 responsive genes	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	1026,7157,57060,25946	CDKN1A,TP53,PCBP4,ZNF385A
R-HSA-173107	Binding and entry of HIV virion	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	7852,1234,5478,920	CXCR4,CCR5,PPIA,CD4
R-HSA-5579026	Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	112812,1583,2232,2230	FDX2,CYP11A1,FDXR,FDX1
R-HSA-173736	Alternative complement activation	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	3004,1675,629,718	GZMM,CFD,CFB,C3
R-HSA-4551638	SUMOylation of chromatin organization proteins	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	83746,6613,7329,8554	L3MBTL2,SUMO2,UBE2I,PIAS1
R-HSA-1251932	PLCG1 events in ERBB2 signaling	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	2064,5335,1950,1956	ERBB2,PLCG1,EGF,EGFR
R-HSA-428542	Regulation of Commissural axon pathfinding by Slit and Robo	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	6091,9353,6092,64221	ROBO1,SLIT2,ROBO2,ROBO3
R-HSA-167060	NGF processing	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	4803,5046,5045,5125	NGF,PCSK6,FURIN,PCSK5
R-HSA-417973	Adenosine P1 receptors	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	136,134,140,135	ADORA2B,ADORA1,ADORA3,ADORA2A
R-HSA-211163	AKT-mediated inactivation of FOXO1A	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	208,10000,207,2308	AKT2,AKT3,AKT1,FOXO1
R-HSA-5603037	IRAK4 deficiency (TLR5)	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	51135,7100,4615,81793	IRAK4,TLR5,MYD88,TLR10
R-HSA-442745	Activation of CaMK IV	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	814,808,801,805	CAMK4,CALM3,CALM1,CALM2
R-HSA-112126	ALKBH3 mediated reversal of alkylation damage	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	221120,84164,10973,51008	ALKBH3,ASCC2,ASCC3,ASCC1
R-HSA-6783984	Glycine degradation	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	1738,2731,275,2653	DLD,GLDC,AMT,GCSH
R-HSA-5250968	Toxicity of botulinum toxin type A (BoNT/A)	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	9899,9900,6616,22987	SV2B,SV2A,SNAP25,SV2C
R-HSA-888593	Reuptake of GABA	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	6538,6540,6529,6539	SLC6A11,SLC6A13,SLC6A1,SLC6A12
R-HSA-1296025	ATP sensitive Potassium channels	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	6833,3764,10060,3767	ABCC8,KCNJ8,ABCC9,KCNJ11
R-HSA-2408550	Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	7296,9061,2936,9060	TXNRD1,PAPSS1,GSR,PAPSS2
R-HSA-8849474	PTK6 Activates STAT3	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	5753,55620,6774,9021	PTK6,STAP2,STAT3,SOCS3
R-HSA-194306	Neurophilin interactions with VEGF and VEGFR	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	8829,2321,3791,8828	NRP1,FLT1,KDR,NRP2
R-HSA-8935690	Miscellaneous digestion events	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	248,2984,2981,2980	ALPI,GUCY2C,GUCA2B,GUCA2A
R-HSA-2473224	Antagonism of Activin by Follistatin	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	3624,10272,3625,10468	INHBA,FSTL3,INHBB,FST
R-HSA-204626	Hypusine synthesis from eIF5A-lysine	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	56648,1984,1725,83475	EIF5A2,EIF5A,DHPS,DOHH
R-HSA-5221030	TET1,2,3 and TDG demethylate DNA	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	6996,80312,200424,54790	TDG,TET1,TET3,TET2
R-HSA-428776	Class II GLUTs	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	6518,155184,56606,66035	SLC2A5,SLC2A7,SLC2A9,SLC2A11
R-HSA-209905	Catecholamine biosynthesis	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	1644,5409,7054,1621	DDC,PNMT,TH,DBH
R-HSA-427975	Proton/oligopeptide cotransporters	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	51296,6564,121260,6565	SLC15A3,SLC15A1,SLC15A4,SLC15A2
R-HSA-6802953	RAS signaling downstream of NF1 loss-of-function variants	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	4893,4763,3265,3845	NRAS,NF1,HRAS,KRAS
R-HSA-3000497	Scavenging by Class H Receptors	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	338,6678,23166,55576	APOB,SPARC,STAB1,STAB2
R-HSA-112313	Neurotransmitter uptake and Metabolism In Glial Cells	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	2752,6507,6506,81539	GLUL,SLC1A3,SLC1A2,SLC38A1
R-HSA-209563	Axonal growth stimulation	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	396,4804,4803,387	ARHGDIA,NGFR,NGF,RHOA
R-HSA-210455	Astrocytic Glutamate-Glutamine Uptake And Metabolism	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	6506,81539,6507,2752	SLC1A2,SLC38A1,SLC1A3,GLUL
R-HSA-8866906	TFAP2 (AP-2) family regulates transcription of other transcription factors	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	7022,7020,10370,5308	TFAP2C,TFAP2A,CITED2,PITX2
R-HSA-69895	Transcriptional  activation of  cell cycle inhibitor p21	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	1026,7157,57060,25946	CDKN1A,TP53,PCBP4,ZNF385A
R-HSA-446343	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	55742,3688,5829,3611	PARVA,ITGB1,PXN,ILK
R-HSA-390650	Histamine receptors	0.595207052328823	-0.518845946862712	4	4	0.000442771751162276	9034	10285	59340,11255,3269,3274	HRH4,HRH3,HRH1,HRH2
R-HSA-6782315	tRNA modification in the nucleus and cytosol	0.595882008205929	-0.517712604324835	42	37	0.00409563869825105	9034	10285	55644,127253,79691,51605,81890,57570,129450,91801,80324,81605,54901,23536,54920,90353,2058,93587,115708,54888,348180,57604,54482,152992,54517,1787,55621,54802,60487,10785,221078,51504,55253,51002,54974,113179,55039,112858,134637	OSGEP,TYW3,QTRT2,TRMT6,QTRT1,TRMT5,TYW5,ALKBH8,PUS1,URM1,CDKAL1,ADAT1,DUS2,CTU1,EPRS1,TRMT10A,TRMT61A,NSUN2,CTU2,TRMT9B,TRMT13,TRMT44,PUS7,TRDMT1,TRMT1,TRIT1,TRMT11,WDR4,NSUN6,TRMT112,TYW1,TPRKB,THG1L,ADAT3,TRMT12,TP53RK,ADAT2
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	0.595882008205929	-0.517712604324835	42	37	0.00409563869825105	9034	10285	7320,7322,3017,8346,5591,51322,8344,8915,8348,54623,7311,9781,9646,7323,7332,10670,7316,8345,8347,8341,220441,7314,79577,3018,123169,8340,51255,8343,8970,8339,7324,56254,23168,9810,6233,7334,7321	UBE2B,UBE2D2,H2BC5,H2BC10,PRKDC,WAC,H2BC6,BCL10,H2BC17,PAF1,UBA52,RNF144A,CTR9,UBE2D3,UBE2L3,RRAGA,UBC,H2BC9,H2BC4,H2BC15,RNF152,UBB,CDC73,H2BC3,LEO1,H2BC13,RNF181,H2BC7,H2BC11,H2BC8,UBE2E1,RNF20,RTF1,RNF40,RPS27A,UBE2N,UBE2D1
R-HSA-1643685	Disease	0.596424247878234	-0.516803039845203	858	752	0.0832410892185079	9034	10285	375,6217,348995,2801,5606,5096,5718,3549,10014,23327,9611,6774,7852,3714,4254,2260,100126332,2984,6135,4927,81793,2243,8027,6210,81929,6877,5431,8437,6156,114609,207,200958,2998,7855,1213,824,5156,7514,5691,9510,182,10533,2475,112755,11095,51497,4001,5781,9146,3674,5719,9688,51065,22906,929,9861,904,5527,10762,2064,5091,55746,6133,80731,3667,8106,11052,6455,552,51606,122706,4893,2931,55901,7979,23493,79718,6144,4057,51224,920,6500,10082,7957,1523,5696,10018,1439,8178,81792,80351,8831,6175,5507,831,1794,7097,2549,11168,130340,995,6194,2645,5947,8546,6189,4041,2817,79412,673,54492,57670,6201,2331,81693,140766,8731,91782,129401,9978,100302213,811,3838,23521,51510,6843,2308,6017,50852,2309,3839,89780,54567,4793,5296,2060,6188,4296,2885,5702,2961,5516,9150,4140,55706,7040,7314,29080,84168,6206,11044,8812,5682,79885,902,9715,6881,4792,6654,50846,51652,6124,10675,170689,4588,31,7251,10418,9672,8065,80070,5610,6777,23279,4589,5291,2264,9899,4594,6924,91445,55750,23225,10613,2237,170690,339366,394263,6874,1080,112812,1174,6165,57085,2230,166785,5594,5335,3717,8815,5685,25873,100506888,5694,5611,64220,1634,4736,2253,5434,84290,23643,6233,6169,84447,6880,3280,9365,4585,4233,5443,60489,80853,127833,2066,54894,5062,1463,4969,551,10898,3164,7046,9900,170691,2534,9719,208,3105,6168,6146,1488,54507,5290,83999,999,5708,6616,4088,6154,3084,1462,23636,4583,6207,7415,5154,283455,91319,6235,611,7296,79139,2255,4040,905,79720,3159,5604,140801,11174,6232,6776,2960,9972,2252,2967,4089,9734,6227,919,801,9507,94025,6917,5950,56667,143662,375790,2266,2248,409,3417,9397,79902,55690,4853,805,1022,948,56999,26281,6224,7311,5713,7175,2280,10417,6385,25978,994,153090,54518,356,6382,11064,100101267,6204,7520,51534,3066,6157,221981,10827,2249,5906,64223,8805,9372,6829,3981,7057,8822,213,26508,6921,6383,5715,23164,6749,57122,1234,11093,2261,4855,5526,5921,388585,9965,2959,8021,10053,2992,54845,892,7316,9759,6138,7001,79849,55534,821,11081,22916,7100,6884,6464,2958,4000,1839,55294,1387,6139,3840,7096,100302237,1605,2071,5690,930,163,9818,5901,4836,5430,8907,399687,7409,5095,51293,7099,9208,3725,27044,5528,3516,5605,3082,1464,6152,6199,10333,23499,1938,27006,5664,6136,79643,7414,5155,2932,3843,1027,6155,941,1211,5693,79023,1020,7098,2254,5433,118430,727897,5529,7450,6234,102,2246,6129,5717,84335,685,10071,162,9061,8851,5692,6456,23198,4928,143471,170692,5710,5432,6857,160,56922,6176,6879,6400,10015,2997,5879,1385,8503,5695,8029,9612,27183,3320,6128,4552,3845,5908,1950,7249,5037,148022,567,5245,10254,9542,5706,7469,79875,653509,7518,118788,2646,9794,79109,9636,222236,10818,8325,140453,64926,4548,10256,4060,4854,3932,4331,138474,1583,51121,11140,5295,83860,6223,6714,5714,3551,9844,8322,2963,928,6161,6416,11096,5549,23385,6882,4791,1445,993,5515,808,23145,8945,1024,92949,56829,253260,145957,6230,6205,2335,253970,10956,9525,5701,2962,8323,6868,3767,2250,2069,83933,3837,6883,9491,8087,7276,5440,5045,164,9631,23511,2068,4686,7048,8732,4869,6202,2965,8454,5686,2547,11173,142678,5293,10000,9530,6166,6229,157869,9509,5441,3265,79872,6208,6441,7187,6142,100302242,5707,4087,823,2251,5700,1104,404672,729238,128866,6231,92421,408,6048,55048,51135,9444,926,5720,55109,2244,161,8074,2065,8660,9349,3978,29851,53371,6209,2694,137492,9508,6228,100847012,6181,2968,6934,1147,5519,7270,8841,7750,3690,291,2232,324,942,6772,4615,63827,3836,8086,940,4790,6143,402569,6160,11198,22938,6469,6648,5518,1487,3921,9037,6167,55615,5894,11097,8817,5687,613,3815,5711,5902,27123,6122,10718,10142,81794,6130,8826,8850,6439,351,5684,2033,6137,5595,5699,1500,6164,176,1175,27121,5439,1499,6875,842,1452,5698,4193,1026,3065,11224,23165,10213,116832,8658,22987,2957,6844,51107,57188,2926,9462,5922,22943,26127,2262,4763,6833,3339,5905,867,6125,84441,5608,6873,118429,11160,5970,83464,1173,5525,7529,2247,4958,9846,6827,9883,7531,6457,9045,7936,5478,2263,23462,6159,10197,8312,5159,6923,200916,162699,27249,10156,171019,54437,3326,5704,6123,5903,100302168,1956,4609,8315,4158,7058,5609,553,5170,5052,51564,9148	ARF1,RPS16,NUP43,GOLGA2,MAP2K3,PCCB,PSMD12,IHH,HDAC5,NEDD4L,NCOR1,STAT3,CXCR4,JAG2,KITLG,FGFR1,MIR943,GUCY2C,RPL11,NUP88,TLR10,FGA,STAM,RPS15A,SEH1L,TAF5,POLR2B,RASAL1,RPL30,TIRAP,AKT1,MUC20,GYS2,FZD5,CLTC,CAPN2,PDGFRA,XPO1,PSMB3,ADAMTS1,JAG1,ATG7,MTOR,STX1B,ADAMTS8,NELFCD,LMNB1,PTPN11,HGS,ITGA2B,PSMD13,NUP93,RPS27L,TRAK1,CD14,PSMD6,CCNT1,PPP2R5C,NUP50,ERBB2,PC,NUP133,RPL9,THSD7B,IRS1,PABPN1,CPSF6,SH3GL1,AVPR1A,ATP6V1H,PSMB11,NRAS,GSK3A,THSD1,SEM1,HEY2,TBL1XR1,RPL21,LTF,ELOA2,CD4,SKP1,GPC6,EPM2A,CUX1,PSMB8,BCL2L11,CSF2RB,ELL,ADAMTS12,TNKS2,SYNGAP1,RPLP0,PPP1R3C,CAST,DOCK2,TLR2,GAB1,PSIP1,AP1S3,CDC25C,RPS6,GCK,RBP1,AP3B1,RPS3A,LRP5,GPC1,KREMEN2,BRAF,NEURL1B,KIAA1549,RPS7,FMOD,AMN,ADAMTS14,RNMT,CHMP7,NUP35,RBX1,MIR1181,CALR,KPNA2,RPL13A,CHMP5,VAMP1,FOXO1,RLBP1,TRAT1,FOXO3,KPNA3,WNT3A,DLL4,NFKBIB,PIK3R2,EPS15,RPS3,MAP3K11,GRB2,PSMC3,GTF2E2,PPP2CB,CTDP1,MARK3,NDC1,TGFB1,UBB,CCDC59,ANTXR1,RPS12,TENT4A,CCNK,PSMA1,HDAC11,CCNH,FAM131B,TAF10,NFKBIA,SOS1,DHH,CHMP3,RPL4,CSPG5,ADAMTS15,MUC6,ACACA,TSG101,SPON1,SDC3,CUL5,ADAMTS20,EIF2AK2,STAT5B,NUP160,MUC7,PIK3CB,FGFR4,SV2B,MMUT,ELOA,RNF185,AGK,NUP210,ERLIN1,FEN1,ADAMTS16,ADAMTSL5,MUC21,TAF4,CFTR,FDX2,AP1S1,RPL35A,AGTRAP,FDX1,MMAA,MAPK1,PLCG1,JAK2,BANF1,PSMA4,RPL36,ELOA3DP,PSMB6,DNAJC3,STRA6,DCN,RPL10A,FGF8,POLR2E,CAPNS2,LY96,RPS27A,RPL38,SYVN1,TAF9,HES1,KL,MUC4,MET,POMC,APOBEC3G,KDM7A,SYT2,ERBB4,RNF43,PAK2,NCAN,OGN,AVP,CPSF4,NR4A1,TGFBR1,SV2A,ADAMTS17,FYN,ADAMTSL2,AKT2,HLA-A,RPL37A,RPL22,CTBP2,ADAMTSL4,PIK3CA,KREMEN1,CDH1,PSMD2,SNAP25,SMAD3,RPL26,NRG1,VCAN,NUP62,MUC2,RPS13,VCP,PDGFA,KSR2,DERL3,RPS29,OPN1SW,TXNRD1,DERL1,FGF10,LRP6,CCNT2,VPS37B,HMGA1,MAP2K1,RPL10L,ADAMTS6,RPS27,STAT5A,GTF2E1,NUP153,FGF7,GTF2H3,SMAD4,HDAC9,RPS21,CD247,CALM1,ADAMTS4,MUC16,TCEA1,RBP4,MUC13,MUC15,AGRN,FGG,FGF3,ARRB2,IDH1,NMT2,NUP85,PACS1,NOTCH2,CALM2,CDK7,CD36,ADAMTS9,FGF20,RPS20,UBA52,PSMD7,TPR,FKBP1A,SPON2,SDC4,CHMP2B,CDC25B,DAB2IP,APBB1IP,FASLG,SDC1,CNTRL,POM121C,RPS10,XRCC5,VTA1,HDAC2,RPL27A,THSD7A,FAM114A2,FGF4,RAP1A,MLST8,TRIM24,ZFYVE9,SUPT5H,LIG4,THBS1,FGF17,ALB,HEYL,ELOC,SDC2,PSMD9,MPRIP,SSRP1,NUP107,CCR5,ADAMTS13,FGFR3,NOTCH4,PPP2R5B,RASA1,HES5,FGF19,GTF2B,NUP214,AP1M2,GYG1,ESRP1,CCNC,UBC,HDAC4,RPL15,PRDX2,NHERF4,MAML3,CANX,KERA,NCBP2,TLR5,TAF13,SHC1,GTF2A2,LMNA,HBEGF,FBXW7,CREBBP,RPL17,KPNA4,TLR1,MIR1281,DAG1,ERCC3,PSMB2,CD19,AP2B1,NUP58,RAN,NMT1,POLR2A,AP1M1,MYO18A,VAV1,PCCA,CD320,TLR4,LRRFIP1,JUN,SND1,PPP2R5D,RBPJ,MAP2K2,HGF,CSPG4,RPL24,RPS6KB2,TLR6,MACF1,EEF2,FGF22,PSEN2,RPL12,CHMP6,VCL,PDGFB,GSK3B,IPO5,CDKN1B,RPL27,CD80,CLTA,PSMB5,NUP37,CDK5,TLR3,FGF9,POLR2D,MUCL1,MUC5B,PPP2R5E,VWF,RPS28,ADAM10,FGF1,RPL7,PSMD11,AKT1S1,BTC,MUC12,AP1B1,PAPSS1,CDK5R1,PSMB4,SH3GL2,PSME4,NUP98,PSMA8,ADAMTS18,PSMD4,POLR2C,SYT1,AP2A1,MCCC1,RPLP1,TAF7,SEL1L,PDCD6IP,GYS1,RAC1,CREB1,PIK3R3,PSMB7,CUBN,NCOR2,VPS4A,HSP90AA1,RPL6,MTRR,KRAS,RAP1B,EGF,TSC2,PEBP1,TICAM1,B2M,PHB1,STAM2,NRG2,PSMC6,NELFA,THSD4,SFTPA1,XRCC4,PIK3AP1,GCKR,MAML1,MAPKAP1,ISG15,NAPEPLD,FRS2,FZD8,MUC17,RASAL3,MTR,CNKSR1,LUM,NOTCH3,LCK,MNAT1,TAF1L,CYP11A1,RPL26L1,CDC37,PIK3R1,TAF3,RPS19,SRC,PSMD8,IKBKB,ELMO1,FZD4,GTF2F2,CD9,RPL32,MAP2K4,ADAMTS5,PRELP,NCSTN,TAF11,NFKB2,CSK,CDC25A,PPP2CA,CALM3,SSPOP,BTRC,CDK8,ADAMTSL1,ZC3HAV1,RICTOR,NRG4,RPS25,RPS11,FN1,SFTA3,OS9,VPS4B,PSMC2,GTF2F1,FZD6,ADAM17,KCNJ11,FGF5,EREG,HDAC10,KPNB1,TAF12,PSMF1,FXR1,TTR,POLR2K,FURIN,AP1G1,NUP155,NUP188,ERCC2,NCBP1,TGFBR2,RNGTT,NPM1,RPS8,GTF2H1,CUL1,PSMA5,XRCC6,ADAMTS7,MIB2,PIK3CD,AKT3,BAG4,RPL36AL,RPS24,SBSPON,ADAMTS2,POLR2L,HRAS,CBLL1,RPS14,SFTPD,TRAF3,RPL18A,MIR1236,PSMD1,SMAD2,CAPN1,FGF6,PSMC1,RCC1,GTF2H5,SFTPA2,CHMP4B,RPS26,CHMP4C,ARRB1,RNF5,VPS37C,IRAK4,QKI,CD8B,PSME1,AGGF1,FGB,AP2A2,FGF23,ERBB3,IRS2,RPL23,LIG1,ICOS,NUP54,RPS15,CBLIF,VPS37A,ADAMTS3,RPS23,MIR5004,RPLP2,GTF2H4,TCF7L2,CHUK,PPP2R1B,TTF1,HDAC3,ZMYM2,ITGB3,SLC25A4,FDXR,APC,CD86,STAT1,MYD88,BCAN,KPNA1,AAAS,CD28,NFKB1,RPL19,KPNA7,RPL31,SUPT16H,SNW1,SHH,SOD2,PPP2R1A,CTBP1,RPSA,SEMA5A,RPL37,PRR5,RAF1,NUP42,FGF18,PSMA6,BCR,KIT,PSMD5,RANBP1,DKK2,RPL3,NRG3,AKAP9,ADAMTS10,RPL7A,IQGAP1,KAT2B,SFTPB,APP,PSMA3,EP300,RPL13,MAPK3,PSMB10,CTNND1,RPL34,ACAN,AP2S1,DKK4,POLR2J,CTNNB1,TAF4B,CASP9,CSNK1A1,PSMB9,MDM2,CDKN1A,HDAC1,RPL35,NUP205,PSMD14,RPL39L,TNKS,SV2C,GTF2A1,VAMP2,APH1A,ADAMTSL3,GRSF1,RASAL2,RASA2,DKK1,FGFR1OP2,GPC5,NF1,ABCC8,HSPG2,RANGAP1,CBL,RPL5,MAML2,MAP2K6,TAF2,ANTXR2,ERLIN2,RELA,APH1B,AP2M1,PPP2R5A,YWHAB,FGF2,OMD,GAB2,SUPT4H1,POM121,YWHAE,SH3GL3,RPL14,NELFE,PPIA,FGFR2,HEY1,RPL29,PSME3,AXIN1,PDGFRB,ELOB,RPL22L1,ELOA3P,MMADHC,RASA4,ADAMTS19,SEMA5B,HSP90AB1,PSMC4,RPL3L,RANBP2,MIR1257,EGFR,MYC,BRAP,MC2R,THBS2,MAP2K7,AVPR1B,PDPK1,PRDX1,HDAC7,NEURL1
R-HSA-76005	Response to elevated platelet cytosolic Ca2+	0.598974136336742	-0.512536859867766	137	120	0.0132831525348683	9034	10285	6813,29106,5196,7423,335,710,83706,5660,5552,5579,5175,5005,22915,23052,801,3827,7043,1950,5099,1521,5874,3481,334,2162,967,51571,10184,813,7044,51706,2335,3690,5154,2153,3273,1072,808,5340,9749,78991,9948,3959,88,5578,6814,350,7424,7277,3479,1191,5345,5478,22927,12,55664,6414,10257,51368,81,5054,3699,66005,6810,6403,3700,6678,928,3309,7414,5155,27154,2244,29789,87,10490,8407,7057,5768,374354,3674,2,213,5265,5582,7450,5627,5267,308,7040,6647,1893,7873,54676,10447,197,7078,5919,7422,5004,54495,6694,135228,7273,259215,51097,5216,2266,5341,226,7042,7018,3082,805,351,3671,2243,948,7123,10487,1675	STXBP2,SCG3,PF4,VEGFB,APOA1,SERPING1,FERMT3,PSAP,SRGN,PRKCB,PECAM1,ORM2,MMRN1,ENDOD1,CALM1,KNG1,TGFB3,EGF,PCDH7,CTSW,RAB27B,IGF2,APLP2,F13A1,CD63,CYRIB,LHFPL2,CALU,LEFTY2,CYB5R1,FN1,ITGB3,PDGFA,F5,HRG,CFL1,CALM3,PLG,PHACTR2,PCYOX1L,WDR1,LGALS3BP,ACTN2,PRKCA,STXBP3,APOH,VEGFC,TUBA4A,IGF1,CLU,SERPINF2,PPIA,HABP4,SERPINA3,CDC37L1,SELENOP,ABCC4,TEX264,ACTN4,SERPINE1,ITIH3,CHID1,STX4,SELP,ITIH4,SPARC,CD9,HSPA5,VCL,PDGFB,BRPF3,FGB,OLA1,ACTN1,VTI1B,TAGLN2,THBS1,QSOX1,NHLRC2,ITGA2B,A2M,ALB,SERPINA1,PRKCG,VWF,PROS1,SERPINA4,ANXA5,TGFB1,SOD1,ECM1,MANF,GTPBP2,FAM3C,AHSG,TIMP3,RARRES2,VEGFA,ORM1,TMX3,SPP2,CD109,TTN,LY6G6F,SCCPDH,PFN1,FGG,PLEK,ALDOA,TGFB2,TF,HGF,CALM2,APP,ISLR,FGA,CD36,CLEC3B,CAP1,CFD
R-HSA-2173789	TGF-beta receptor signaling activates SMADs	0.600867359614026	-0.509381068282138	34	30	0.00332078813371707	9034	10285	9958,25805,7316,5045,9110,7314,7040,2280,867,5501,57154,23645,7311,4089,9372,7048,7514,64750,23327,56937,6233,7046,4087,5500,4088,10273,51377,11171,4092,5499	USP15,BAMBI,UBC,FURIN,MTMR4,UBB,TGFB1,FKBP1A,CBL,PPP1CC,SMURF1,PPP1R15A,UBA52,SMAD4,ZFYVE9,TGFBR2,XPO1,SMURF2,NEDD4L,PMEPA1,RPS27A,TGFBR1,SMAD2,PPP1CB,SMAD3,STUB1,UCHL5,STRAP,SMAD7,PPP1CA
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.600867359614026	-0.509381068282138	34	30	0.00332078813371707	9034	10285	7316,892,6667,1030,905,60436,5933,7314,22938,7029,4089,7311,4609,1875,7027,3726,4087,4221,6233,5054,3065,4088,7050,8812,1024,904,4092,25937,54778,1874	UBC,CCNC,SP1,CDKN2B,CCNT2,TGIF2,RBL1,UBB,SNW1,TFDP2,SMAD4,UBA52,MYC,E2F5,TFDP1,JUNB,SMAD2,MEN1,RPS27A,SERPINE1,HDAC1,SMAD3,TGIF1,CCNK,CDK8,CCNT1,SMAD7,WWTR1,RNF111,E2F4
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs	0.601832476852386	-0.507776150053571	89	78	0.00863404914766438	9034	10285	79961,27342,5874,122553,22878,55667,51112,10000,84079,208,414918,8408,57679,58485,11031,5869,22930,163259,79890,1122,27095,10890,5872,81846,221960,27147,207,5864,10981,57589,22931,5878,163486,3257,51762,25782,4218,160518,79958,23258,10260,259173,6764,54734,51552,83696,11021,9610,51560,23682,7531,7879,84315,26130,5873,9909,80006,5861,60684,117177,51693,8567,54453,201627,5870,57706,81876,22879,201475,5868,2665,22898,89781,5866,79090,23011,126432,7109	DENND2D,RABGEF1,RAB27B,TRAPPC6B,TRAPPC8,DENND4C,TRAPPC12,AKT3,ANKRD27,AKT2,DENND6B,ULK1,ALS2,TRAPPC1,RAB31,RAB5B,RAB3GAP1,DENND2C,RIN3,CHML,TRAPPC3,RAB10,RAB13,SBF2,CCZ1B,DENND2A,AKT1,RAB3A,RAB32,RIC1,RAB18,RAB5C,DENND1B,HPS1,RAB8B,RAB3GAP2,RAB8A,DENND5B,DENND1C,DENND5A,DENND4A,ALS2CL,DENND2B,RAB39A,RAB14,TRAPPC9,RAB35,RIN1,RAB6B,RAB38,YWHAE,RAB7A,MON1A,GAPVD1,RAB27A,DENND4B,TRAPPC13,RAB1A,TRAPPC11,RAB3IP,TRAPPC2L,MADD,RIN2,DENND6A,RAB6A,DENND1A,RAB1B,MON1B,RAB12,RAB5A,GDI2,DENND3,HPS4,RAB3IL1,TRAPPC6A,RAB21,RINL,TRAPPC10
R-HSA-1980143	Signaling by NOTCH1	0.604688712814544	-0.503041477637812	73	64	0.00708434801859641	9034	10285	2033,7311,3280,7089,83933,3714,23462,79718,55534,23493,7316,408,892,5664,9759,9978,83464,1024,3516,8841,9794,8850,6233,388585,9611,54492,79885,10014,409,92737,6868,9734,100302237,8454,8788,8650,9612,22938,23385,7091,7314,84441,26508,102,3091,9148,51564,142678,83737,1272,7088,6500,23220,3065,7090,182,51107,1840,4609,54567,113878,3066,55294,1387	EP300,UBA52,HES1,TLE2,HDAC10,JAG2,HEY1,TBL1XR1,MAML3,HEY2,UBC,ARRB1,CCNC,PSEN2,HDAC4,RBX1,APH1B,CDK8,RBPJ,HDAC3,MAML1,KAT2B,RPS27A,HES5,NCOR1,NEURL1B,HDAC11,HDAC5,ARRB2,DNER,ADAM17,HDAC9,MIR1281,CUL1,DLK1,NUMB,NCOR2,SNW1,NCSTN,TLE4,UBB,MAML2,HEYL,ADAM10,HIF1A,NEURL1,HDAC7,MIB2,ITCH,CNTN1,TLE1,SKP1,DTX4,HDAC1,TLE3,JAG1,APH1A,DTX1,MYC,DLL4,DTX2,HDAC2,FBXW7,CREBBP
R-HSA-3371378	Regulation by c-FLIP	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	355,356,8795,8737,8772,8717,8797,8743,8837,841	FAS,FASLG,TNFRSF10B,RIPK1,FADD,TRADD,TNFRSF10A,TNFSF10,CFLAR,CASP8
R-HSA-2514853	Condensation of Prometaphase Chromosomes	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	9918,9133,891,983,10592,23397,10051,1457,1459,64151	NCAPD2,CCNB2,CCNB1,CDK1,SMC2,NCAPH,SMC4,CSNK2A1,CSNK2A2,NCAPG
R-HSA-211999	CYP2E1 reactions	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	1572,1555,1559,1548,1557,1565,29785,1553,1558,1549	CYP2F1,CYP2B6,CYP2C9,CYP2A6,CYP2C19,CYP2D6,CYP2S1,CYP2A13,CYP2C8,CYP2A7
R-HSA-5661231	Metallothioneins bind metals	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	4502,4495,4490,84560,4499,4489,4493,4494,4504,4501	MT2A,MT1G,MT1B,MT4,MT1M,MT1A,MT1E,MT1F,MT3,MT1X
R-HSA-71288	Creatine metabolism	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	6538,6534,1158,1152,1159,2628,548596,6539,2593,1160	SLC6A11,SLC6A7,CKM,CKB,CKMT1B,GATM,CKMT1A,SLC6A12,GAMT,CKMT2
R-HSA-2022923	Dermatan sulfate biosynthesis	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	29940,113189,10675,1462,92126,1463,1464,10090,1634,63827	DSE,CHST14,CSPG5,VCAN,DSEL,NCAN,CSPG4,UST,DCN,BCAN
R-HSA-5660526	Response to metal ions	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	4504,4501,4494,4493,4489,84560,4499,4490,4502,4495	MT3,MT1X,MT1F,MT1E,MT1A,MT4,MT1M,MT1B,MT2A,MT1G
R-HSA-69416	Dimerization of procaspase-8	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	355,8795,356,8737,8717,8772,8797,8743,8837,841	FAS,TNFRSF10B,FASLG,RIPK1,TRADD,FADD,TNFRSF10A,TNFSF10,CFLAR,CASP8
R-HSA-189451	Heme biosynthesis	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	1371,3145,210,211,2235,5498,7389,7390,1352,1355	CPOX,HMBS,ALAD,ALAS1,FECH,PPOX,UROD,UROS,COX10,COX15
R-HSA-77588	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	22916,134353,25888,6637,6636,6635,4686,6628,7884,84967	NCBP2,LSM11,ZNF473,SNRPG,SNRPF,SNRPE,NCBP1,SNRPB,SLBP,LSM10
R-HSA-418889	Ligand-independent caspase activation via DCC	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	842,26060,1612,23604,1630,219699,836,1613,90249,693222	CASP9,APPL1,DAPK1,DAPK2,DCC,UNC5B,CASP3,DAPK3,UNC5A,MIR637
R-HSA-8875555	MET activates RAP1 and RAC1	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	5908,4233,1398,2549,3082,5879,2885,5906,85440,2889	RAP1B,MET,CRK,GAB1,HGF,RAC1,GRB2,RAP1A,DOCK7,RAPGEF1
R-HSA-5218900	CASP8 activity is inhibited	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	8837,841,355,8743,8772,8717,8797,8737,356,8795	CFLAR,CASP8,FAS,TNFSF10,FADD,TRADD,TNFRSF10A,RIPK1,FASLG,TNFRSF10B
R-HSA-174414	Processive synthesis on the C-strand of the telomere	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	5111,2237,6117,6119,3978,6118,10714,1763,5424,57804	PCNA,FEN1,RPA1,RPA3,LIG1,RPA2,POLD3,DNA2,POLD1,POLD4
R-HSA-5602498	MyD88 deficiency (TLR2/4)	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	4615,51135,7097,7096,7099,948,114609,10333,23643,929	MYD88,IRAK4,TLR2,TLR1,TLR4,CD36,TIRAP,TLR6,LY96,CD14
R-HSA-5603041	IRAK4 deficiency (TLR2/4)	0.605845381201628	-0.501130472000203	11	10	0.00110692937790569	9034	10285	10333,23643,929,114609,948,7097,7096,7099,51135,4615	TLR6,LY96,CD14,TIRAP,CD36,TLR2,TLR1,TLR4,IRAK4,MYD88
R-HSA-69563	p53-Dependent G1 DNA Damage Response	0.606818958050737	-0.499524789328141	65	57	0.00630949745406243	9034	10285	4193,64326,5698,5704,1026,8900,5720,5696,10213,5691,890,1027,5714,11200,5695,5693,5686,5702,5690,472,25946,9134,5687,57060,5719,5685,7314,9861,5694,5711,5708,5682,5715,5706,5717,5701,5718,5707,6233,4194,122706,5684,1017,10197,5700,9491,7311,5699,5692,7316,7979,7157,23198,5713,898,5710,143471	MDM2,COP1,PSMB9,PSMC4,CDKN1A,CCNA1,PSME1,PSMB8,PSMD14,PSMB3,CCNA2,CDKN1B,PSMD8,CHEK2,PSMB7,PSMB5,PSMA5,PSMC3,PSMB2,ATM,ZNF385A,CCNE2,PSMA6,PCBP4,PSMD13,PSMA4,UBB,PSMD6,PSMB6,PSMD5,PSMD2,PSMA1,PSMD9,PSMC6,PSMD11,PSMC2,PSMD12,PSMD1,RPS27A,MDM4,PSMB11,PSMA3,CDK2,PSME3,PSMC1,PSMF1,UBA52,PSMB10,PSMB4,UBC,SEM1,TP53,PSME4,PSMD7,CCNE1,PSMD4,PSMA8
R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint	0.606818958050737	-0.499524789328141	65	57	0.00630949745406243	9034	10285	5710,143471,7316,7979,7157,5713,23198,898,5700,10197,9491,7311,5699,5692,4194,122706,5684,1017,5707,6233,5701,5718,5682,5715,5706,5717,9861,5694,5711,5708,5687,57060,5685,5719,7314,25946,9134,5686,5702,5690,472,5693,5695,890,5691,1027,5714,11200,8900,5720,5696,10213,4193,64326,5698,5704,1026	PSMD4,PSMA8,UBC,SEM1,TP53,PSMD7,PSME4,CCNE1,PSMC1,PSME3,PSMF1,UBA52,PSMB10,PSMB4,MDM4,PSMB11,PSMA3,CDK2,PSMD1,RPS27A,PSMC2,PSMD12,PSMA1,PSMD9,PSMC6,PSMD11,PSMD6,PSMB6,PSMD5,PSMD2,PSMA6,PCBP4,PSMA4,PSMD13,UBB,ZNF385A,CCNE2,PSMA5,PSMC3,PSMB2,ATM,PSMB5,PSMB7,CCNA2,PSMB3,CDKN1B,PSMD8,CHEK2,CCNA1,PSME1,PSMB8,PSMD14,MDM2,COP1,PSMB9,PSMC4,CDKN1A
R-HSA-194315	Signaling by Rho GTPases	0.606910588858263	-0.499373798841119	426	373	0.0412884657958822	9034	10285	5501,5747,55288,23370,286205,10094,23191,5905,79784,54908,2,9793,64837,6655,220134,4627,26999,100288637,752,171177,3012,1857,7456,7532,128239,3799,147841,388,389337,805,3015,1535,11130,5595,71,8976,8347,3798,8361,1499,58504,8997,8340,60,23421,613,8363,201176,9886,5216,25791,3688,124056,6249,8826,79902,143872,29984,3985,1742,1058,58480,23433,5170,23526,23380,7409,22899,9411,8349,50650,50508,8362,5903,4690,4628,100302274,8936,396,998,7531,10810,10095,8366,121504,8348,11214,55789,4629,55701,8365,391,7984,55845,7529,9912,5525,54509,84144,7533,653604,57122,5289,64946,3013,54820,5526,10006,23779,4771,57584,8874,11113,389,8352,8335,5062,23263,57522,100271715,89941,1124,57569,55114,55766,4688,644150,9184,9475,5048,79980,7074,3831,10276,4689,5880,121512,114793,6396,5585,57120,8355,5586,147700,116985,221472,23221,5518,10726,3633,3020,10451,397,57082,23365,8344,801,1060,57551,3071,85415,9743,9639,6232,11243,10096,4649,93663,55920,10672,85360,8353,55839,653361,57449,64411,999,2665,701,30849,9826,5519,10787,10109,9928,147179,401541,2885,8364,51306,723790,5516,9212,79822,387,1729,1063,5515,57514,8379,79172,257106,23332,151648,392,6714,84986,26230,3895,3021,4221,5296,83540,10163,2810,94274,64105,2017,57636,51517,10458,3984,10097,8350,23092,94239,9828,81930,57591,995,79658,1894,8357,6722,57381,151246,4085,9901,4660,1080,10403,399,80776,5594,7534,8359,23002,9938,23279,10152,128312,5924,29941,90627,23028,81624,89846,22919,89839,7410,80152,1062,9138,126961,10499,8370,808,79682,5881,8339,23081,8358,25936,8968,9055,6654,79023,94134,91010,11004,9181,25909,103910,100616122,5529,9183,9824,55843,83478,1856,26084,1027,128272,394,10093,4650,1855,25,7514,27237,84033,10971,8346,445328,3017,8368,23122,84904,1123,343578,116984,8345,9735,57580,57405,81929,114822,3817,348995,3619,29127,79019,51466,8970,5528,117289,4637,6453,10788,5058,10552,5217,2909,50649,10928,332,30851,64333,354,1495,29,91614,84643,9322,5879,10144,8354,991,5500,8334,7204,89953,10092,81565,4928,3018,54763,8367,3796,5347,8341,699,55055,10398,4638,8360,5527,8343,55746,4659,6242,10395,55160	PPP1CC,PTK2,RHOT1,ARHGEF18,SCAI,ARPC3,CYFIP1,RANGAP1,MYH14,SPDL1,A2M,CKAP5,KLC2,SOS2,SKA1,MYH9,CYFIP2,LOC100288637,FMNL1,RHOV,H2AC8,DVL3,WIPF1,YWHAG,IQGAP3,KIF5B,SPC24,RHOB,ARHGEF37,CALM2,H2AZ1,CYBA,ZWINT,MAPK3,ACTG1,WASL,H2BC4,KIF5A,H4C6,CTNNB1,ARHGAP22,KALRN,H2BC13,ACTB,ITGB3BP,BCR,H4C11,ARHGAP27,RHOBTB1,PFN1,NGEF,ITGB1,NOXO1,CLIP1,IQGAP1,NUP85,ARHGAP42,RHOD,LIMK2,DLG4,CENPA,RHOU,RHOQ,PDPK1,ARHGAP45,SRGAP2,VAV1,ARHGEF15,ARHGAP29,H2BC21,ARHGEF3,NOX3,H4C12,RANBP2,NCK1,MYH10,MIR1178,WASF1,ARHGDIA,CDC42,YWHAE,WASF3,ARPC1B,H4C2,H4C16,H2BC17,AKAP13,DEPDC1B,MYH11,ARHGEF40,H4C8,RHOG,ARHGEF5,BRK1,YWHAB,ARHGAP44,PPP2R5A,RHOF,SYDE2,YWHAH,H3C13,NUP107,PIK3C3,CENPH,H2AC7,NDE1,PPP2R5B,ABI1,ARHGAP8,NF2,ARHGAP21,ARHGEF7,CIT,RHOC,H3C3,H2AC4,PAK2,MCF2L,SRGAP1,ARHGEF33,RHOT2,CHN2,ARHGAP20,ARHGAP17,H2AJ,NCF2,WIPF3,BUB3,ROCK2,PAFAH1B1,DSN1,TIAM1,KLC1,NET1,NCF4,RAC2,FGD4,FMNL2,SEC13,PKN1,GOPC,H3C8,PKN2,KLC3,ARAP1,FGD2,RHOBTB2,PPP2R1A,NUDC,INPP5B,H3-3A,VAV3,ARHGDIB,KNL1,ARHGEF12,H2BC6,CALM1,CENPC,TAOK1,NCKAP1L,RHPN2,ARHGAP32,ARHGEF10,RPS27,PMF1,ACTR3,MYO9A,ARHGAP18,RCC2,GNA13,SYDE1,H3C6,CENPN,NCF1,PLEKHG5,ARAP3,CDH1,GDI2,BUB1B,PIK3R4,ARHGEF11,PPP2R1B,NCKAP1,ARPC2,KIF14,WIPF2,CENPP,GRB2,H4C3,FAM13B,H2AC19,PPP2CB,AURKB,ARHGAP28,RHOA,DIAPH1,CENPF,PPP2CA,ARHGAP31,MAD1L1,CENPO,ARHGAP30,CLASP1,SGO1,ARHGAP1,SRC,ARHGAP19,TIAM2,KTN1,H3-3B,MEN1,PIK3R2,NUF2,WASF2,SFN,PPP1R14A,CENPK,CTTN,ARHGAP23,NCKIPSD,BAIAP2,LIMK1,ACTR2,H3C1,ARHGAP26,H2AZ2,ARHGEF17,KIF18A,MRTFA,CDC25C,ARHGAP10,ECT2,H3C10,SRF,RHOJ,SGO2,MAD2L1,SRGAP3,PPP1R12B,CFTR,NDC80,RHOH,B9D2,MAPK1,YWHAZ,H4C1,DAAM1,ARHGAP25,NUP160,ABI2,H2BC26,RASGRF2,PKN3,STARD13,KDM1A,DIAPH3,FGD3,MAPRE1,ARHGAP11B,VAV2,CENPT,CENPE,ARHGEF1,H3C14,NCOA2,H4C14,CALM3,CENPU,RAC3,H2BC8,KDM4C,H3C2,NSL1,H3C7,PRC1,SOS1,NUP37,ARHGAP12,FMNL3,KIF2C,ARHGEF2,AHCTF1,MYL12B,MIR4523,PPP2R5E,ZW10,ARHGAP11A,ARHGAP15,ARHGAP24,DVL2,ARHGEF26,CDKN1B,ARHGEF19,ARHGAP5,ARPC4,MYO9B,DVL1,ABL1,XPO1,ARHGEF16,OBSCN,YWHAQ,H2BC10,ARHGEF35,H2BC5,H4C13,CLASP2,ARHGEF39,CHN1,ARHGAP40,ARAP2,H2BC9,KNTC1,PREX1,SPC25,SEH1L,RHPN1,KLK2,NUP43,INCENP,RACGAP1,CENPM,EVL,H2BC11,PPP2R5D,TAGAP,MYL6,ITSN1,IQGAP2,PAK1,ARPC1A,PFN2,ARHGAP35,ARHGEF4,RALBP1,BIRC5,TAX1BP3,ARHGAP9,KLK3,CTNNA1,ABR,DEPDC7,KIF2B,TRIP10,RAC1,FAM13A,H3C11,CDC20,PPP1CB,H2AC6,TRIO,KLC4,ARPC5,NDEL1,NUP98,H2BC3,ROPN1,H4C5,KIF2A,PLK1,H2BC15,BUB1,ZWILCH,MYL9,MYLK,H4C4,PPP2R5C,H2BC7,NUP133,PPP1R12A,RTKN,DLC1,ARHGEF10L
R-HSA-379716	Cytosolic tRNA aminoacylation	0.608740972715996	-0.496362433909261	26	23	0.00254593756918309	9034	10285	2617,4677,3376,5917,1615,2058,6897,7453,7965,16,7407,4141,51520,2193,9521,3735,5464,8565,6301,833,5859,10056,9255	GARS1,NARS1,IARS1,RARS1,DARS1,EPRS1,TARS1,WARS1,AIMP2,AARS1,VARS1,MARS1,LARS1,FARSA,EEF1E1,KARS1,PPA1,YARS1,SARS1,CARS1,QARS1,FARSB,AIMP1
R-HSA-5617833	Cilium Assembly	0.610523929569579	-0.49343778952538	192	168	0.0185964135488156	9034	10285	55212,27031,100616329,27241,9727,54536,11190,5310,51259,55125,5147,166379,10121,7846,9793,6010,28981,129880,11020,79659,9702,54930,8766,22994,8195,54806,54585,80173,11064,23332,79598,89891,83657,9657,55755,79959,60412,7532,7840,10540,26146,79809,79969,4867,5577,1639,149371,84100,6991,26005,5048,23354,121441,56912,57576,9321,95681,55722,26123,93323,5566,85302,9742,26160,4957,22897,8729,140735,92482,117177,10575,22981,11336,10576,10142,57545,80184,84902,10640,80776,4751,11127,50807,403,3320,57539,51626,5518,983,192668,11258,2847,583,6753,146057,200132,1262,1453,84131,10382,261734,83658,79989,55081,22832,57728,10733,5311,55835,55770,255758,8655,150737,582,22920,55763,91147,3797,80321,378,132320,7531,1258,23059,22919,7277,8100,112752,23265,57787,5347,4218,57560,64792,203068,79600,22995,9814,347240,1778,585,79441,23322,79867,79738,22948,1781,54801,51098,9662,80254,115106,10806,27077,51134,10694,123016,54903,54820,55112,5108,92104,6608,3842,84747,55764,1454,51668	BBS7,NPHP3,MIR4700,BBS9,RAB11FIP3,EXOC6,CEP250,PKD1,TMEM216,CEP192,PDE6D,BBS12,ACTR1A,TUBA1A,CKAP5,RHO,IFT81,BBS5,IFT27,DYNC2H1,CEP57,HAUS4,RAB11A,CEP131,MKKS,AHI1,LZTFL1,IFT74,CNTRL,CLASP1,CEP97,DYNC2I2,DYNLRB2,IQCB1,CDK5RAP2,CEP76,EXOC4,YWHAG,ALMS1,DCTN2,TRAF3IP1,TTC21B,ATAT1,NPHP1,PRKAR2B,DCTN1,EXOC8,ARL6,DYNLT2,C2CD3,PAFAH1B1,HAUS5,NEDD1,IFT46,KIF17,TRIP11,CEP41,CEP72,TCTN3,HAUS8,PRKACA,FBF1,IFT140,IFT172,ODF2,CEP164,GBF1,DYNLL2,BBIP1,RAB3IP,CCT4,NINL,EXOC3,CCT2,AKAP9,CC2D2A,CEP290,CEP89,EXOC5,B9D2,NEK2,KIF3A,ASAP1,ARL3,HSP90AA1,WDR35,DYNC2LI1,PPP2R1A,CDK1,CYS1,DCTN3,MCHR1,BBS2,SSTR3,TTBK2,DYNLT5,CNGA4,CSNK1D,CEP78,TUBB4A,NPHP4,DYNLRB1,IFT56,IFT57,CEP162,WDR19,PLK4,PKD2,CENPJ,EXOC2,DYNLT2B,DYNLL1,IFT70B,BBS1,KIFAP3,EXOC1,TMEM67,KIF3C,CEP70,ARF4,SCLT1,YWHAE,CNGB1,CLUAP1,MAPRE1,TUBA4A,IFT88,IFT43,EXOC7,MARK4,PLK1,RAB8A,IFT80,IFT22,TUBB,TCTN1,CEP152,SFI1,KIF24,DYNC1H1,BBS4,HAUS3,RPGRIP1L,TCTN2,BBS10,CCT5,DYNC1I2,HAUS6,IFT52,CEP135,CEP63,HAUS1,SDCCAG8,B9D1,CEP83,CCT8,TTC8,MKS1,NDE1,DYNC2I1,PCM1,IFT70A,SMO,TNPO1,UNC119B,IFT122,CSNK1E,IFT25
R-HSA-69202	Cyclin E associated events during G1/S transition	0.621811173478852	-0.475118811948572	72	63	0.00697365508080584	9034	10285	5925,5701,5718,902,5707,6233,595,9861,6502,5694,5711,5708,5682,5715,5706,5717,4149,7316,7979,5713,898,5710,1022,5684,1017,5700,10197,9491,7311,5699,5692,890,4609,5691,1027,5714,1019,5695,6500,5698,5704,1026,4331,8900,5720,5696,207,10213,993,9134,10000,5687,5719,7465,5685,7314,5693,5753,5686,208,8454,5702,5690	RB1,PSMC2,PSMD12,CCNH,PSMD1,RPS27A,CCND1,PSMD6,SKP2,PSMB6,PSMD5,PSMD2,PSMA1,PSMD9,PSMC6,PSMD11,MAX,UBC,SEM1,PSMD7,CCNE1,PSMD4,CDK7,PSMA3,CDK2,PSMC1,PSME3,PSMF1,UBA52,PSMB10,PSMB4,CCNA2,MYC,PSMB3,CDKN1B,PSMD8,CDK4,PSMB7,SKP1,PSMB9,PSMC4,CDKN1A,MNAT1,CCNA1,PSME1,PSMB8,AKT1,PSMD14,CDC25A,CCNE2,AKT3,PSMA6,PSMD13,WEE1,PSMA4,UBB,PSMB5,PTK6,PSMA5,AKT2,CUL1,PSMC3,PSMB2
R-HSA-69052	Switching of origins to a post-replicative state	0.621811173478852	-0.475118811948572	72	63	0.00697365508080584	9034	10285	5694,9861,5711,5708,5715,5682,5717,5706,4172,5701,5925,5718,4998,5707,6233,4174,122706,1017,5684,9491,5700,10197,7311,5692,5699,7979,7316,23198,5713,143471,5710,23594,4173,5698,990,5704,1026,5720,8900,5001,10213,5696,5691,890,84515,5714,1027,5695,5693,5686,5702,5690,4171,5000,51343,81620,5687,5685,23595,4999,5719,7314,4175	PSMB6,PSMD6,PSMD5,PSMD2,PSMD9,PSMA1,PSMD11,PSMC6,MCM3,PSMC2,RB1,PSMD12,ORC1,PSMD1,RPS27A,MCM5,PSMB11,CDK2,PSMA3,PSMF1,PSMC1,PSME3,UBA52,PSMB4,PSMB10,SEM1,UBC,PSME4,PSMD7,PSMA8,PSMD4,ORC6,MCM4,PSMB9,CDC6,PSMC4,CDKN1A,PSME1,CCNA1,ORC5,PSMD14,PSMB8,PSMB3,CCNA2,MCM8,PSMD8,CDKN1B,PSMB7,PSMB5,PSMA5,PSMC3,PSMB2,MCM2,ORC4,FZR1,CDT1,PSMA6,PSMA4,ORC3,ORC2,PSMD13,UBB,MCM6
R-HSA-68949	Orc1 removal from chromatin	0.621811173478852	-0.475118811948572	72	63	0.00697365508080584	9034	10285	9491,5700,10197,5692,5699,7311,4174,1017,5684,122706,143471,5710,23594,7979,7316,23198,5713,5717,5706,5715,5682,4172,5694,9861,5708,5711,5707,6233,4998,5718,5925,5701,5702,5686,5690,5693,5685,4999,5719,23595,51343,5687,81620,7314,4175,5000,4171,5720,8900,10213,5696,5001,5698,990,4173,5704,1026,5695,84515,890,5691,5714,1027	PSMF1,PSMC1,PSME3,PSMB4,PSMB10,UBA52,MCM5,CDK2,PSMA3,PSMB11,PSMA8,PSMD4,ORC6,SEM1,UBC,PSME4,PSMD7,PSMD11,PSMC6,PSMD9,PSMA1,MCM3,PSMB6,PSMD6,PSMD2,PSMD5,PSMD1,RPS27A,ORC1,PSMD12,RB1,PSMC2,PSMC3,PSMA5,PSMB2,PSMB5,PSMA4,ORC2,PSMD13,ORC3,FZR1,PSMA6,CDT1,UBB,MCM6,ORC4,MCM2,PSME1,CCNA1,PSMD14,PSMB8,ORC5,PSMB9,CDC6,MCM4,PSMC4,CDKN1A,PSMB7,MCM8,CCNA2,PSMB3,PSMD8,CDKN1B
R-HSA-181429	Serotonin Neurotransmitter Release Cycle	0.622480867276639	-0.474042386414185	18	16	0.0017710870046491	9034	10285	6844,6812,22999,6857,6571,8224,8500,8541,10815,8497,5864,9256,10497,8499,6616,6854	VAMP2,STXBP1,RIMS1,SYT1,SLC18A2,SYN3,PPFIA1,PPFIA3,CPLX1,PPFIA4,RAB3A,TSPOAP1,UNC13B,PPFIA2,SNAP25,SYN2
R-HSA-197264	Nicotinamide salvaging	0.622480867276639	-0.474042386414185	18	16	0.0017710870046491	9034	10285	4837,1582,9390,83666,128240,56965,84875,5743,54956,10135,160728,143,5740,83594,54625,55739	NNMT,CYP8B1,SLC22A13,PARP9,NAXE,PARP6,PARP10,PTGS2,PARP16,NAMPT,SLC5A8,PARP4,PTGIS,NUDT12,PARP14,NAXD
R-HSA-1369062	ABC transporters in lipid homeostasis	0.622480867276639	-0.474042386414185	18	16	0.0017710870046491	9034	10285	64137,10350,64241,8504,10349,21,5824,23460,335,9619,225,10347,23461,26154,5825,64240	ABCG4,ABCA9,ABCG8,PEX3,ABCA10,ABCA3,PEX19,ABCA6,APOA1,ABCG1,ABCD2,ABCA7,ABCA5,ABCA12,ABCD3,ABCG5
R-HSA-1482925	Acyl chain remodelling of PG	0.622480867276639	-0.474042386414185	18	16	0.0017710870046491	9034	10285	30814,5322,64600,255189,5320,22925,26279,9926,50487,54675,5319,5321,100137049,283748,81579,79888	PLA2G2E,PLA2G5,PLA2G2F,PLA2G4F,PLA2G2A,PLA2R1,PLA2G2D,LPGAT1,PLA2G3,CRLS1,PLA2G1B,PLA2G4A,PLA2G4B,PLA2G4D,PLA2G12A,LPCAT1
R-HSA-912631	Regulation of signaling by CBL	0.622480867276639	-0.474042386414185	18	16	0.0017710870046491	9034	10285	5291,2885,2534,6850,1398,5295,4067,2889,5293,29760,7525,7409,867,8503,5290,5296	PIK3CB,GRB2,FYN,SYK,CRK,PIK3R1,LYN,RAPGEF1,PIK3CD,BLNK,YES1,VAV1,CBL,PIK3R3,PIK3CA,PIK3R2
R-HSA-181430	Norepinephrine Neurotransmitter Release Cycle	0.622480867276639	-0.474042386414185	18	16	0.0017710870046491	9034	10285	6571,6857,6844,22999,6812,10815,8497,8541,8500,5864,8499,6582,6580,6616,10497,9256	SLC18A2,SYT1,VAMP2,RIMS1,STXBP1,CPLX1,PPFIA4,PPFIA3,PPFIA1,RAB3A,PPFIA2,SLC22A2,SLC22A1,SNAP25,UNC13B,TSPOAP1
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	0.623051977665531	-0.473125332430044	311	272	0.0301084790790348	9034	10285	84676,64410,5690,7323,54850,7174,5686,51088,8454,84937,26267,9690,142678,146330,222235,84708,7428,197131,5685,23352,26224,5704,90025,3093,202658,26235,140458,201456,83737,9903,10489,55294,64750,114907,7321,10324,57520,64718,79654,55008,9820,10197,9491,91694,6923,51320,7316,92912,114088,6478,8065,140739,55284,8945,51666,283807,100616150,6502,6921,401036,23014,997,285231,5071,11065,7324,92591,5682,9320,5715,8453,5701,142685,140460,23291,4591,140459,10393,4008,51434,29116,9817,5702,27252,5930,55905,26272,26268,7314,51619,8452,9354,89910,84541,7326,57674,5698,144699,142686,10213,53339,5714,55236,64320,10425,7325,868,122769,5684,7322,26091,6477,7311,154881,5699,10616,25793,54926,84861,5713,9978,6737,150726,5711,51465,9730,7337,51444,9867,23304,26234,154214,5706,255488,118424,55175,899,89890,55070,115290,9666,64682,22888,79754,57542,25898,26270,26190,11059,23376,26223,11275,9246,5687,26046,26249,6500,10273,10193,7328,26232,5696,4734,51191,991,5695,7334,223082,51130,9604,9520,6047,122706,127544,57630,84261,5692,642,10477,390594,23198,92369,996,7979,80176,140691,5710,143471,5708,55819,9616,9861,22954,84085,51665,55182,54620,6468,5717,51676,143279,26263,8925,25897,29945,63891,7320,5693,23194,55658,55521,7332,89122,25831,8916,51343,5719,8924,221687,80196,57531,8139,54778,5720,126433,80028,6049,51433,7327,5691,8697,90678,55958,10533,8651,55585,63893,23295,57154,136371,65264,100847079,5700,90933,10293,9021,7704,51529,7318,127247,148581,79876,84231,5694,84078,7335,84961,200845,93611,9870,140461,131405,5718,7336,23608,6233,4012,9039,23327,79791,26259,5707	TRIM63,KLHL25,PSMB2,UBE2D3,FBXL12,TPP2,PSMA5,KLHL5,CUL1,ZNRF1,FBXO10,UBE3C,MIB2,FBXL16,FBXL13,LNX1,VHL,UBR1,PSMA4,UBR4,FBXL3,PSMC4,UBE3D,UBE2K,TRIM39-RPP21,FBXL4,ASB5,FBXO15,ITCH,KLHL21,LRRC41,FBXW7,SMURF2,FBXO32,UBE2D1,KLHL41,HECW2,UNKL,HECTD3,HERC6,CUL7,PSME3,PSMF1,LONRF1,ELOB,MEX3C,UBC,UBE2Q2,TRIM9,SIAH2,CUL5,UBE2F,UBE2W,BTRC,ASB4,FBXL22,MIR4720,SKP2,ELOC,ASB18,FBXO21,CDC34,FBXW12,PRKN,UBE2C,UBE2E1,ASB16,PSMA1,TRIP12,PSMD9,CUL2,PSMC2,ASB15,ASB7,FBXW11,TRIM37,ASB6,ANAPC10,LMO7,ANAPC7,MYLIP,KEAP1,PSMC3,KLHL20,RBBP6,RNF114,FBXO4,FBXO9,UBB,UBE2D4,CUL3,UBE4A,UBE3B,KBTBD8,UBE2G1,RNF213,PSMB9,FBXL14,ASB14,PSMD14,BTBD1,PSMD8,UBA6,RNF25,ARIH2,UBE2E2,CBLB,LRR1,PSMA3,UBE2D2,HERC4,SIAH1,UBA52,KCTD7,PSMB10,RBCK1,FBXO7,UBE2R2,KLHL22,PSMD7,RBX1,TRIM21,FBXO41,PSMD5,UBE2J1,DCAF1,UBE3A,RNF138,PJA2,UBR2,FBXL5,RNF217,PSMC6,RNF144B,UBE2J2,KLHL11,CCNF,KBTBD6,DET1,FBXO17,DZIP3,ANAPC1,UBOX5,ASB13,KLHL42,RCHY1,FBXO6,FBXW2,WWP1,UFL1,FBXL21P,KLHL2,UBE2L6,PSMA6,LTN1,KLHL3,SKP1,STUB1,RNF41,UBE2H,FBXO2,PSMB8,NEDD4,HERC5,CDC20,PSMB7,UBE2N,ZNRF2,ASB3,RNF14,NPEPPS,RNF4,PSMB11,RNF19B,SH3RF1,FBXW9,PSMB4,BLMH,UBE2E3,KBTBD13,PSME4,SPSB4,CDC27,SEM1,SPSB1,TRIM69,PSMD4,PSMA8,PSMD2,RNF130,RNF7,PSMD6,TRIM32,FBXO30,ASB1,RNF220,FBXL19,FBXW4,PSMD11,ASB2,HECTD2,FBXO22,HERC1,RNF19A,ANAPC4,RNF123,UBE2B,PSMB5,FBXL7,RNF126,TRIM36,UBE2L3,TRIM4,HECTD1,HERC3,FZR1,PSMD13,HERC2,RNF182,RNF34,HACE1,GAN,RNF111,PSME1,FBXO27,FBXL18,RNF6,ANAPC5,UBE2G2,PSMB3,CDC23,LRSAM1,KLHL9,ATG7,SOCS1,UBE2Q1,UBE2O,MGRN1,SMURF1,ASB10,UBE2Z,MIR5193,PSMC1,TRIM41,TRAIP,SOCS3,ZBTB16,ANAPC11,UBA7,ASB17,UBE2U,UBA5,TRAF7,PSMB6,KBTBD7,UBE2V1,FBXL20,KCTD6,FBXO44,AREL1,ASB8,TRIM71,PSMD12,UBE2V2,MKRN1,RPS27A,LNPEP,UBA3,NEDD4L,FBXO31,FBXW8,PSMD1
R-HSA-1980145	Signaling by NOTCH2	0.626247795821135	-0.468009146236146	33	29	0.0032100951959265	9034	10285	3516,9794,182,6233,388585,51107,54492,1385,54567,83464,1272,4192,3002,55534,7314,84441,102,9148,2208,142678,7316,5664,2033,100302237,7311,3280,3714,4853,23385	RBPJ,MAML1,JAG1,RPS27A,HES5,APH1A,NEURL1B,CREB1,DLL4,APH1B,CNTN1,MDK,GZMB,MAML3,UBB,MAML2,ADAM10,NEURL1,FCER2,MIB2,UBC,PSEN2,EP300,MIR1281,UBA52,HES1,JAG2,NOTCH2,NCSTN
R-HSA-68877	Mitotic Prometaphase	0.627171963648879	-0.466534511759975	111	97	0.0107372149656852	9034	10285	983,5518,10726,1058,10403,57082,80776,10592,57551,1060,10274,332,113130,23279,84643,5903,991,6232,64151,11243,22919,55920,55839,23244,1062,4928,81565,80152,3796,5347,1459,79682,23047,55055,699,5525,5519,5527,701,25936,57122,9133,55746,5526,54820,23397,10051,64946,5501,9918,79023,401541,11004,5516,9126,9212,5905,8379,79172,5515,5529,100616122,9793,25909,1063,54908,151648,891,220134,9183,23332,1457,7514,147841,5048,23063,83540,9184,11130,23122,64105,79980,9735,57405,81929,5885,81930,348995,23421,79019,6396,3619,5528,4085,79902,151246,6249	CDK1,PPP2R1A,NUDC,CENPA,NDC80,KNL1,B9D2,SMC2,TAOK1,CENPC,STAG1,BIRC5,CDCA5,NUP160,KIF2B,RANBP2,CDC20,RPS27,NCAPG,PMF1,MAPRE1,RCC2,CENPN,PDS5A,CENPE,NUP98,NDEL1,CENPT,KIF2A,PLK1,CSNK2A2,CENPU,PDS5B,ZWILCH,BUB1,PPP2R5A,PPP2R1B,PPP2R5C,BUB1B,NSL1,NUP107,CCNB2,NUP133,PPP2R5B,NDE1,NCAPH,SMC4,CENPH,PPP1CC,NCAPD2,NUP37,CENPP,KIF2C,PPP2CB,SMC3,AURKB,RANGAP1,MAD1L1,CENPO,PPP2CA,PPP2R5E,MIR4523,CKAP5,AHCTF1,CENPF,SPDL1,SGO1,CCNB1,SKA1,ZW10,CLASP1,CSNK2A1,XPO1,SPC24,PAFAH1B1,WAPL,NUF2,BUB3,ZWINT,CLASP2,CENPK,DSN1,KNTC1,SPC25,SEH1L,RAD21,KIF18A,NUP43,ITGB3BP,CENPM,SEC13,INCENP,PPP2R5D,MAD2L1,NUP85,SGO2,CLIP1
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	0.628708875107861	-0.464086967090467	103	90	0.00996236440115121	9034	10285	57551,1060,10274,113130,332,983,5518,10726,1058,10403,80776,57082,991,6232,11243,23279,84643,5903,55839,23244,1062,4928,81565,80152,3796,5347,22919,55920,25936,57122,9133,55746,5526,54820,64946,79682,23047,55055,699,5525,5519,5527,701,9212,5905,8379,79172,5515,5529,100616122,9793,25909,1063,54908,5501,79023,401541,5516,11004,9126,7514,147841,151648,891,220134,9183,23332,9735,57405,81929,5048,23063,83540,9184,11130,23122,64105,79980,5528,79902,4085,151246,6249,5885,81930,348995,23421,79019,6396,3619	TAOK1,CENPC,STAG1,CDCA5,BIRC5,CDK1,PPP2R1A,NUDC,CENPA,NDC80,B9D2,KNL1,CDC20,RPS27,PMF1,NUP160,KIF2B,RANBP2,CENPN,PDS5A,CENPE,NUP98,NDEL1,CENPT,KIF2A,PLK1,MAPRE1,RCC2,NSL1,NUP107,CCNB2,NUP133,PPP2R5B,NDE1,CENPH,CENPU,PDS5B,ZWILCH,BUB1,PPP2R5A,PPP2R1B,PPP2R5C,BUB1B,AURKB,RANGAP1,MAD1L1,CENPO,PPP2CA,PPP2R5E,MIR4523,CKAP5,AHCTF1,CENPF,SPDL1,PPP1CC,NUP37,CENPP,PPP2CB,KIF2C,SMC3,XPO1,SPC24,SGO1,CCNB1,SKA1,ZW10,CLASP1,KNTC1,SPC25,SEH1L,PAFAH1B1,WAPL,NUF2,BUB3,ZWINT,CLASP2,CENPK,DSN1,PPP2R5D,NUP85,MAD2L1,SGO2,CLIP1,RAD21,KIF18A,NUP43,ITGB3BP,CENPM,SEC13,INCENP
R-HSA-453276	Regulation of mitotic cell cycle	0.63279655923693	-0.457606299906102	87	76	0.00841266327208324	9034	10285	6790,9212,119504,5685,5719,51343,5687,7314,983,5693,64682,10393,29945,5702,8454,5686,4751,5690,51434,991,8697,890,5691,9232,51433,5714,7321,5695,5698,891,6500,5704,5720,8900,10213,5696,7979,26271,51529,7316,996,8556,5713,23198,143471,5347,5710,1017,5684,9184,122706,9491,5700,10197,5692,5699,7311,5718,5701,5707,4085,25906,6233,5694,6502,9861,5708,5711,8945,5717,5706,5715,5682,7324,701,11065	AURKA,AURKB,ANAPC16,PSMA4,PSMD13,FZR1,PSMA6,UBB,CDK1,PSMB5,ANAPC1,ANAPC10,ANAPC4,PSMC3,CUL1,PSMA5,NEK2,PSMB2,ANAPC7,CDC20,CDC23,CCNA2,PSMB3,PTTG1,ANAPC5,PSMD8,UBE2D1,PSMB7,PSMB9,CCNB1,SKP1,PSMC4,PSME1,CCNA1,PSMD14,PSMB8,SEM1,FBXO5,ANAPC11,UBC,CDC27,CDC14A,PSMD7,PSME4,PSMA8,PLK1,PSMD4,CDK2,PSMA3,BUB3,PSMB11,PSMF1,PSMC1,PSME3,PSMB4,PSMB10,UBA52,PSMD12,PSMC2,PSMD1,MAD2L1,ANAPC15,RPS27A,PSMB6,SKP2,PSMD6,PSMD2,PSMD5,BTRC,PSMD11,PSMC6,PSMD9,PSMA1,UBE2E1,BUB1B,UBE2C
R-HSA-5419276	Mitochondrial translation termination	0.63279655923693	-0.457606299906102	87	76	0.00841266327208324	9034	10285	84545,55052,51650,9553,116541,64951,63931,6182,11222,116540,54948,51258,51073,64981,7818,65080,55168,64979,64928,51373,64963,128308,26589,740,64983,55037,51649,54534,64969,65008,78988,54998,28957,28977,64960,79590,6183,54148,64976,51642,64968,28998,64432,51318,90480,60488,63875,64978,65003,54516,92399,51021,64965,51264,122704,118487,10884,10573,84311,51263,219927,51023,3396,54460,124995,84340,56945,55173,92259,9801,29093,51253,57129,10240,29088,23107	MRPL43,MRPL20,MRPS33,MRPL33,MRPL54,MRPS24,MRPS14,MRPL12,MRPL3,MRPL53,MRPL16,MRPL51,MRPL4,MRPL34,DAP3,MRPL44,MRPS18A,MRPL36,MRPL14,MRPS17,MRPS11,MRPL55,MRPL46,MRPL49,MRPL32,PTCD3,MRPS23,MRPL50,MRPS5,MRPL1,MRPL57,AURKAIP1,MRPS28,MRPL42,MRPS15,MRPL24,MRPS12,MRPL39,MRPL40,MRPL48,MRPS6,MRPL13,MRPS25,MRPL35,GADD45GIP1,MRPS35,MRPL17,MRPL38,MRPL11,MTRF1L,MRRF,MRPS16,MRPS9,MRPL27,MRPL52,CHCHD1,MRPS30,MRPL28,MRPL45,MRPL30,MRPL21,MRPS18C,MRPL58,MRPS21,MRPL10,GFM2,MRPS22,MRPS10,KGD4,MRPL19,MRPL22,MRPL37,MRPL47,MRPS31,MRPL15,MRPS27
R-HSA-5368286	Mitochondrial translation initiation	0.63279655923693	-0.457606299906102	87	76	0.00841266327208324	9034	10285	65008,64969,28977,28957,54998,78988,740,26589,128308,51373,64928,64963,64979,4528,54534,55037,51649,64983,64981,51258,51073,54948,55168,65080,7818,51650,55052,84545,116540,11222,6182,63931,64951,9553,116541,51253,29093,9801,92259,23107,29088,10240,57129,3396,54460,51023,219927,51263,84311,10573,118487,10884,55173,56945,124995,65003,64978,123263,63875,122704,51264,51021,64965,28998,64968,51642,64976,54148,6183,79590,64960,60488,90480,219402,51318,64432	MRPL1,MRPS5,MRPL42,MRPS28,AURKAIP1,MRPL57,MRPL49,MRPL46,MRPL55,MRPS17,MRPL14,MRPS11,MRPL36,MTIF2,MRPL50,PTCD3,MRPS23,MRPL32,MRPL34,MRPL51,MRPL4,MRPL16,MRPS18A,MRPL44,DAP3,MRPS33,MRPL20,MRPL43,MRPL53,MRPL3,MRPL12,MRPS14,MRPS24,MRPL33,MRPL54,MRPL37,MRPL22,MRPL19,KGD4,MRPS27,MRPL15,MRPS31,MRPL47,MRPL58,MRPS21,MRPS18C,MRPL21,MRPL30,MRPL45,MRPL28,CHCHD1,MRPS30,MRPS10,MRPS22,MRPL10,MRPL11,MRPL38,MTFMT,MRPL17,MRPL52,MRPL27,MRPS16,MRPS9,MRPL13,MRPS6,MRPL48,MRPL40,MRPL39,MRPS12,MRPL24,MRPS15,MRPS35,GADD45GIP1,MTIF3,MRPL35,MRPS25
R-HSA-174143	APC/C-mediated degradation of cell cycle proteins	0.63279655923693	-0.457606299906102	87	76	0.00841266327208324	9034	10285	5718,5701,5707,4085,25906,6233,6502,9861,5694,5708,8945,5711,5706,5717,5682,5715,7324,11065,701,7316,51529,26271,7979,8556,996,23198,5713,5710,143471,5347,5684,9184,1017,122706,5700,10197,9491,5699,5692,7311,8697,991,890,5691,5714,51433,9232,7321,5695,5698,6500,891,5704,8900,5720,5696,10213,6790,9212,119504,5685,5719,5687,51343,7314,10393,64682,5693,983,29945,8454,5702,4751,5686,5690,51434	PSMD12,PSMC2,PSMD1,MAD2L1,ANAPC15,RPS27A,SKP2,PSMD6,PSMB6,PSMD2,BTRC,PSMD5,PSMC6,PSMD11,PSMA1,PSMD9,UBE2E1,UBE2C,BUB1B,UBC,ANAPC11,FBXO5,SEM1,CDC14A,CDC27,PSME4,PSMD7,PSMD4,PSMA8,PLK1,PSMA3,BUB3,CDK2,PSMB11,PSMC1,PSME3,PSMF1,PSMB10,PSMB4,UBA52,CDC23,CDC20,CCNA2,PSMB3,PSMD8,ANAPC5,PTTG1,UBE2D1,PSMB7,PSMB9,SKP1,CCNB1,PSMC4,CCNA1,PSME1,PSMB8,PSMD14,AURKA,AURKB,ANAPC16,PSMA4,PSMD13,PSMA6,FZR1,UBB,ANAPC10,ANAPC1,PSMB5,CDK1,ANAPC4,CUL1,PSMC3,NEK2,PSMA5,PSMB2,ANAPC7
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	0.634319556508507	-0.455202419178746	48	42	0.0046491033872039	9034	10285	9759,9978,7316,892,51564,26508,3091,7314,84441,23493,7091,55534,79718,22938,23462,83933,7089,9612,3280,7311,8454,100302237,2033,9734,1387,55294,3066,10014,79885,4609,9611,388585,6233,8850,9794,8841,3516,3065,7090,6500,7088,1024	HDAC4,RBX1,UBC,CCNC,HDAC7,HEYL,HIF1A,UBB,MAML2,HEY2,TLE4,MAML3,TBL1XR1,SNW1,HEY1,HDAC10,TLE2,NCOR2,HES1,UBA52,CUL1,MIR1281,EP300,HDAC9,CREBBP,FBXW7,HDAC2,HDAC5,HDAC11,MYC,NCOR1,HES5,RPS27A,KAT2B,MAML1,HDAC3,RBPJ,HDAC1,TLE3,SKP1,TLE1,CDK8
R-HSA-194840	Rho GTPase cycle	0.635258935439868	-0.453722590859745	142	124	0.0137259242860306	9034	10285	613,79658,121512,9828,1894,201176,9886,29127,117289,25791,221472,23221,143872,6453,57381,116985,445328,389337,84904,7074,1123,57636,5880,116984,10276,343578,57580,58504,23092,8997,57522,83478,9824,6655,23263,55843,26084,57569,1124,84986,392,89941,100271715,394,128272,4650,26230,171177,100288637,388,55114,5296,27237,84033,55288,23370,23779,51306,94134,57584,8874,9181,57514,257106,79822,2,389,387,9912,54509,9826,5881,2665,84144,6654,55160,10395,89846,7204,89839,998,90627,93663,10672,4649,7410,55701,9138,85360,11214,55789,57449,7984,64411,391,9639,9938,9743,50650,9322,91614,5924,29,5879,10144,396,3633,2909,10451,29984,9901,23365,50649,397,399,10928,23526,58480,23433,22899,9411,64333,23380,7409	BCR,ARHGAP10,FGD4,ARHGEF17,ECT2,ARHGAP27,RHOBTB1,RACGAP1,TAGAP,NGEF,FGD2,RHOBTB2,ARHGAP42,ITSN1,RHOJ,ARAP1,ARHGEF35,ARHGEF37,ARHGEF39,TIAM1,CHN1,ARHGAP23,RAC2,ARAP2,NET1,ARHGAP40,PREX1,ARHGAP22,ARHGAP26,KALRN,SRGAP1,ARHGAP24,ARHGAP11A,SOS2,MCF2L,ARHGAP15,ARHGEF26,ARHGAP20,CHN2,ARHGAP19,ARHGAP1,RHOT2,ARHGEF33,ARHGAP5,ARHGEF19,MYO9B,TIAM2,RHOV,LOC100288637,RHOB,ARHGAP17,PIK3R2,ARHGEF16,OBSCN,RHOT1,ARHGEF18,ARHGAP8,FAM13B,ARHGAP12,ARHGAP21,ARHGEF7,ARHGEF2,ARHGAP31,ARHGAP30,ARHGAP28,A2M,RHOC,RHOA,ARHGAP44,RHOF,ARHGEF11,RAC3,GDI2,SYDE2,SOS1,ARHGEF10L,DLC1,FGD3,TRIO,ARHGAP11B,CDC42,STARD13,ARHGAP18,GNA13,MYO9A,VAV2,ARHGEF40,ARHGEF1,SYDE1,AKAP13,DEPDC1B,PLEKHG5,ARHGEF5,ARAP3,RHOG,ARHGEF10,ARHGAP25,ARHGAP32,ARHGEF3,TRIP10,DEPDC7,RASGRF2,ABR,RAC1,FAM13A,ARHGDIA,INPP5B,ARHGAP35,VAV3,RHOD,SRGAP3,ARHGEF12,ARHGEF4,ARHGDIB,RHOH,RALBP1,ARHGAP45,RHOU,RHOQ,ARHGEF15,ARHGAP29,ARHGAP9,SRGAP2,VAV1
R-HSA-2871837	FCERI mediated NF-kB activation	0.635519867116353	-0.453311926659765	79	69	0.00763781270754926	9034	10285	5696,10213,23118,10892,5720,5704,5698,6500,7334,7321,5695,3551,5714,4790,5691,5690,8454,8915,5702,5686,10454,7189,5693,7314,5719,5685,5687,5170,5706,1147,5717,5682,4067,5715,5708,8945,5711,5970,115727,7335,997,10235,9861,5694,6233,5707,23291,6885,5718,4792,5701,5588,5699,5692,7311,5700,10197,9491,5684,122706,84433,7322,10125,5710,143471,5713,23198,7979,7316	PSMB8,PSMD14,TAB2,MALT1,PSME1,PSMC4,PSMB9,SKP1,UBE2N,UBE2D1,PSMB7,IKBKB,PSMD8,NFKB1,PSMB3,PSMB2,CUL1,BCL10,PSMC3,PSMA5,TAB1,TRAF6,PSMB5,UBB,PSMD13,PSMA4,PSMA6,PDPK1,PSMC6,CHUK,PSMD11,PSMA1,LYN,PSMD9,PSMD2,BTRC,PSMD5,RELA,RASGRP4,UBE2V1,CDC34,RASGRP2,PSMD6,PSMB6,RPS27A,PSMD1,FBXW11,MAP3K7,PSMD12,NFKBIA,PSMC2,PRKCQ,PSMB10,PSMB4,UBA52,PSMC1,PSME3,PSMF1,PSMA3,PSMB11,CARD11,UBE2D2,RASGRP1,PSMD4,PSMA8,PSMD7,PSME4,SEM1,UBC
R-HSA-162909	Host Interactions of HIV factors	0.63633753223809	-0.452026145353148	134	117	0.0129510737214966	9034	10285	5720,23165,100101267,926,10213,5698,3932,5062,9844,53371,5691,7514,161,5714,5702,5693,2534,79023,55706,9688,5719,7314,3105,5905,5706,5694,375,11168,130340,5711,348995,5902,79902,5707,6233,55690,5718,4927,1104,5700,7311,5699,5684,60489,81929,5713,7175,129401,1175,9978,5903,940,5696,6500,23279,160,3159,5704,23511,23225,9972,5695,4869,5879,5686,1174,5690,11097,8907,5687,8815,5685,5901,163,1794,919,567,9818,5715,5682,23636,904,5717,1173,10762,6921,9861,8945,5708,57122,5701,55746,291,9491,10197,5692,162,10053,9883,8021,122706,5478,3837,51606,8065,8086,143471,5710,164,9631,920,6923,7316,7979,23198,4928,3836	PSME1,NUP205,POM121C,CD8B,PSMD14,PSMB9,LCK,PAK2,ELMO1,NUP54,PSMB3,XPO1,AP2A2,PSMD8,PSMC3,PSMB5,FYN,NUP37,NDC1,NUP93,PSMD13,UBB,HLA-A,RANGAP1,PSMC6,PSMB6,ARF1,PSIP1,AP1S3,PSMD5,NUP43,RANBP1,NUP85,PSMD1,RPS27A,PACS1,PSMD12,NUP88,RCC1,PSMC1,UBA52,PSMB10,PSMA3,APOBEC3G,SEH1L,PSMD7,TPR,NUP35,AP2S1,RBX1,RANBP2,CD28,PSMB8,SKP1,NUP160,AP2A1,HMGA1,PSMC4,NUP188,NUP210,NUP153,PSMB7,NPM1,RAC1,PSMA5,AP1S1,PSMB2,NUP42,AP1M1,PSMA6,BANF1,PSMA4,RAN,AP2B1,DOCK2,CD247,B2M,NUP58,PSMD9,PSMA1,NUP62,CCNT1,PSMD11,AP2M1,NUP50,ELOC,PSMD6,BTRC,PSMD2,NUP107,PSMC2,NUP133,SLC25A4,PSMF1,PSME3,PSMB4,AP1B1,AP1M2,POM121,NUP214,PSMB11,PPIA,KPNB1,ATP6V1H,CUL5,AAAS,PSMA8,PSMD4,AP1G1,NUP155,CD4,ELOB,UBC,SEM1,PSME4,NUP98,KPNA1
R-HSA-211981	Xenobiotics	0.637804172750757	-0.449723982014981	25	22	0.00243524463139252	9034	10285	1544,1548,9915,29785,1553,1573,54905,1572,1559,64816,1565,405,100861540,1549,1543,1577,1555,196,1557,1562,1558,1576	CYP1A2,CYP2A6,ARNT2,CYP2S1,CYP2A13,CYP2J2,CYP2W1,CYP2F1,CYP2C9,CYP3A43,CYP2D6,ARNT,CYP3A7-CYP3A51P,CYP2A7,CYP1A1,CYP3A5,CYP2B6,AHR,CYP2C19,CYP2C18,CYP2C8,CYP3A4
R-HSA-198725	Nuclear Events (kinase and transcription factor activation)	0.637804172750757	-0.449723982014981	25	22	0.00243524463139252	9034	10285	9252,5518,5516,5595,4208,9261,5600,1848,5598,4205,51231,5594,5515,466,1846,6196,5519,1432,1385,5528,6195,1849	RPS6KA5,PPP2R1A,PPP2CB,MAPK3,MEF2C,MAPKAPK2,MAPK11,DUSP6,MAPK7,MEF2A,VRK3,MAPK1,PPP2CA,ATF1,DUSP4,RPS6KA2,PPP2R1B,MAPK14,CREB1,PPP2R5D,RPS6KA1,DUSP7
R-HSA-933542	TRAF6 mediated NF-kB activation	0.637804172750757	-0.449723982014981	25	22	0.00243524463139252	9034	10285	4615,4792,3551,4790,4793,4214,3146,23586,7706,84282,7189,351,177,64135,5970,57506,4791,1147,6288,6283,100500827,1660	MYD88,NFKBIA,IKBKB,NFKB1,NFKBIB,MAP3K1,HMGB1,RIGI,TRIM25,RNF135,TRAF6,APP,AGER,IFIH1,RELA,MAVS,NFKB2,CHUK,SAA1,S100A12,MIR3614,DHX9
R-HSA-429947	Deadenylation of mRNA	0.637804172750757	-0.449723982014981	25	22	0.00243524463139252	9034	10285	5073,9125,29883,1974,4848,85456,10605,4849,9924,25904,57472,23019,4850,1981,9337,255967,26986,9775,55571,246175,1977,1975	PARN,CNOT9,CNOT7,EIF4A2,CNOT2,TNKS1BP1,PAIP1,CNOT3,PAN2,CNOT10,CNOT6,CNOT1,CNOT4,EIF4G1,CNOT8,PAN3,PABPC1,EIF4A3,CNOT11,CNOT6L,EIF4E,EIF4B
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	0.637804172750757	-0.449723982014981	25	22	0.00243524463139252	9034	10285	51529,7316,119504,996,7314,64682,10393,29945,9184,4751,7311,51434,991,8697,51433,4085,6233,25906,7321,701,11065,7324	ANAPC11,UBC,ANAPC16,CDC27,UBB,ANAPC1,ANAPC10,ANAPC4,BUB3,NEK2,UBA52,ANAPC7,CDC20,CDC23,ANAPC5,MAD2L1,RPS27A,ANAPC15,UBE2D1,BUB1B,UBE2C,UBE2E1
R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	0.638865646224272	-0.4480611030116	71	62	0.00686296214301528	9034	10285	5684,1017,1022,5699,5692,7311,5700,10197,9491,898,5713,7979,7316,4149,994,5710,5708,5711,6502,9861,5694,5706,5717,5682,5715,5718,902,5701,5925,595,6233,5707,5753,5693,5690,8454,5702,5686,9134,993,7314,7465,5719,5685,5687,51343,4331,1026,5704,5698,6500,5696,10213,8900,5720,1019,1027,5714,890,5691,4609,5695	PSMA3,CDK2,CDK7,PSMB10,PSMB4,UBA52,PSMC1,PSME3,PSMF1,CCNE1,PSMD7,SEM1,UBC,MAX,CDC25B,PSMD4,PSMD2,PSMD5,SKP2,PSMD6,PSMB6,PSMC6,PSMD11,PSMA1,PSMD9,PSMD12,CCNH,PSMC2,RB1,CCND1,RPS27A,PSMD1,PTK6,PSMB5,PSMB2,CUL1,PSMC3,PSMA5,CCNE2,CDC25A,UBB,WEE1,PSMD13,PSMA4,PSMA6,FZR1,MNAT1,CDKN1A,PSMC4,PSMB9,SKP1,PSMB8,PSMD14,CCNA1,PSME1,CDK4,CDKN1B,PSMD8,CCNA2,PSMB3,MYC,PSMB7
R-HSA-535734	Fatty acid, triacylglycerol, and ketone body metabolism	0.639402095836914	-0.447221764543635	253	221	0.0244631392517157	9034	10285	10499,51586,6319,3030,2180,892,37,27242,9440,83401,31,5019,5563,56894,253558,57678,23171,2712,10891,7003,1024,11010,79888,116255,84869,1622,25942,9915,27063,2222,1490,6667,166785,150763,26027,80221,55090,2101,7004,4800,100302237,4899,6721,90390,2819,51129,64900,84693,55750,788,1543,335,197322,137964,2820,346606,1387,4594,23305,54600,142827,65985,57491,23179,3155,122970,4706,7005,79071,2033,948,112950,80306,406,3156,9477,9439,79993,5565,11332,64834,183,5465,1666,23054,9412,2194,253017,150379,56898,8648,58488,1581,80205,10005,85441,56895,51703,196,19,80724,34,26230,9524,6296,55301,35,5538,10226,79718,80168,400569,3992,1632,84246,392636,4802,23097,10001,219541,7296,23309,51003,9200,54898,8841,23205,54511,9967,60481,5468,27349,81857,81616,405,10449,116519,10965,117145,29841,4520,3293,47,26063,5469,3032,2274,9442,6822,9612,1376,51144,51495,6785,6604,622,211,51,55326,10498,6256,84320,8463,3033,344967,7069,79966,3157,11000,84803,9575,54797,5244,1579,1374,133522,10025,6576,9971,9443,376497,6095,9611,284486,29079,5096,201562,9441,2168,2181,4199,5467,23389,25937,401494,5095,96764,8202,641372,33,336,134526,55856,9969,57761,100527964,51422,123,23175,8800,84649,4862,7923,6720,79611,10413,4801,38,9663,50486,9572	NCOA2,MED15,SCD,HADHA,ACSL1,CCNC,ACADVL,TNFRSF21,MED17,ELOVL3,ACACA,OXCT1,PRKAA2,AGPAT3,LCLAT1,GPAM,GPD1L,GK2,PPARGC1A,TEAD1,CDK8,GLIPR1,LPCAT1,MOGAT1,CBR4,DBI,SIN3A,ARNT2,ANKRD1,FDFT1,CCN2,SP1,MMAA,GPAT2,ACOT11,ACSF2,MED9,ESRRA,TEAD4,NFYA,MIR1281,NRF1,SREBF2,MED30,GPD1,ANGPTL4,LPIN3,MCEE,AGK,SLC25A20,CYP1A1,APOA1,ACSF3,GPAT4,GPD2,MOGAT3,CREBBP,MMUT,ACSL6,UGT1A9,ACSM6,AACS,AHRR,RGL1,HMGCL,ACOT4,NDUFAB1,TEAD3,ELOVL6,EP300,CD36,MED8,MED28,BMAL1,HMGCR,MED20,MED23,ELOVL7,PRKAB2,ACOT7,ELOVL1,AGT,PPARA,DECR1,NCOA6,MED21,FASN,TECRL,PNPLA5,BDH2,NCOA1,PCTP,CYP7A1,CHD9,ACOT8,HELZ2,AGPAT4,ACSL5,AHR,ABCA1,ACAD10,ACADM,TIAM2,TECR,ACSM3,OLAH,ACADS,PPT1,PLIN3,TBL1XR1,MOGAT2,MED11,FADS1,ECI1,MED10,AGMO,NFYC,CDK19,MED6,MED19,TXNRD1,SIN3B,MED31,HACD1,ELOVL2,HDAC3,ACSBG1,HMGCLL1,THRAP3,ELOVL5,PPARG,MCAT,MED25,ACSBG2,ARNT,ACAA2,APOA5,ACOT2,THEM4,GRHL1,MTF1,HSD17B3,ACLY,DECR2,MED1,HADHB,FHL2,MED27,SULT2A1,NCOR2,CPT2,HSD17B12,HACD3,ELOVL4,SMARCD3,BDH1,ALAS1,ACOX1,AGPAT5,CARM1,RXRA,ACBD6,TEAD2,HADH,LOC344967,THRSP,SCD5,HMGCS1,SLC27A3,GPAT3,CLOCK,MED18,ABCB4,CYP4A11,CPT1A,PPARGC1B,MED16,SLC25A1,NR1H4,MED7,SLC27A1,RORA,NCOR1,THEM5,MED4,PCCB,HACD2,MED26,FABP1,ACSL3,ME1,PPARD,MED13L,WWTR1,HACD4,PCCA,TGS1,NCOA3,ACOT6,ACADL,APOA2,ACOT12,ACOT13,MED13,TRIB3,LHX4-AS1,PRKAG2,PLIN2,LPIN1,PEX11A,DGAT2,NPAS2,HSD17B8,SREBF1,ACSS3,YAP1,NFYB,ACAT1,LPIN2,G0S2,NR1D1
R-HSA-5368287	Mitochondrial translation	0.64528005186491	-0.43807086748126	94	82	0.00907682089882665	9034	10285	122704,51264,51021,64965,65003,54516,92399,123263,64978,63875,60488,219402,90480,64432,51318,28998,64968,6183,79590,54148,64976,51642,64960,10102,23107,85476,29088,57129,10240,9801,29093,51253,92259,55173,56945,124995,84340,51023,54460,3396,51263,219927,118487,10884,10573,84311,65080,55168,7818,100616256,51258,51073,64981,54948,11222,116540,6182,63931,9553,116541,64951,51650,55052,84545,28977,54998,28957,78988,65008,64969,4528,55037,51649,64983,54534,740,128308,26589,64963,64928,51373,64979	MRPL52,MRPL27,MRPS16,MRPS9,MRPL11,MTRF1L,MRRF,MTFMT,MRPL38,MRPL17,MRPS35,MTIF3,GADD45GIP1,MRPS25,MRPL35,MRPL13,MRPS6,MRPS12,MRPL24,MRPL39,MRPL40,MRPL48,MRPS15,TSFM,MRPS27,GFM1,MRPL15,MRPL47,MRPS31,MRPL19,MRPL22,MRPL37,KGD4,MRPS10,MRPS22,MRPL10,GFM2,MRPS18C,MRPS21,MRPL58,MRPL30,MRPL21,CHCHD1,MRPS30,MRPL28,MRPL45,MRPL44,MRPS18A,DAP3,MIR4721,MRPL51,MRPL4,MRPL34,MRPL16,MRPL3,MRPL53,MRPL12,MRPS14,MRPL33,MRPL54,MRPS24,MRPS33,MRPL20,MRPL43,MRPL42,AURKAIP1,MRPS28,MRPL57,MRPL1,MRPS5,MTIF2,PTCD3,MRPS23,MRPL32,MRPL50,MRPL49,MRPL55,MRPL46,MRPS11,MRPL14,MRPS17,MRPL36
R-HSA-75105	Fatty Acyl-CoA Biosynthesis	0.648295039283817	-0.433409378714132	55	48	0.00531326101394731	9034	10285	197322,55750,55301,84320,5538,23305,9524,58488,641372,80221,26027,1622,47,2194,253017,51144,100527964,51703,51495,6785,134526,10005,55856,11332,60481,201562,81616,64834,54898,23205,284486,401494,3293,2181,117145,10965,122970,79966,2180,11000,6319,344967,6576,79993,9200,79071,31,83401	ACSF3,AGK,OLAH,ACBD6,PPT1,ACSL6,TECR,PCTP,ACOT6,ACSF2,ACOT11,DBI,ACLY,FASN,TECRL,HSD17B12,LHX4-AS1,ACSL5,HACD3,ELOVL4,ACOT12,ACOT8,ACOT13,ACOT7,ELOVL5,HACD2,ACSBG2,ELOVL1,ELOVL2,ACSBG1,THEM5,HACD4,HSD17B3,ACSL3,THEM4,ACOT2,ACOT4,SCD5,ACSL1,SLC27A3,SCD,LOC344967,SLC25A1,ELOVL7,HACD1,ELOVL6,ACACA,ELOVL3
R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	0.651619835725831	-0.428293961149394	78	68	0.00752711976975869	9034	10285	64841,8128,6489,5372,6482,56052,140838,10559,2762,4758,27090,79947,79087,8818,55907,8790,91869,199857,8869,79796,7264,55577,6484,29926,6675,116150,8813,10825,29925,55808,30815,144245,6480,81849,10020,4351,84920,80896,54344,5373,6483,51046,10610,7903,22845,10195,57171,29929,5238,197258,256435,2720,85365,55343,10402,79053,9945,4597,29880,338596,26503,29906,84620,79644,2673,9526,6487,54187	GNPNAT1,ST8SIA2,ST8SIA1,PMM1,ST3GAL1,ALG1,NANP,SLC35A1,GMDS,NEU1,ST6GALNAC4,DHDDS,ALG12,DPM2,CMAS,FPGT,RFT1,ALG14,ST3GAL5,ALG9,GFUS,NAGK,ST3GAL4,GMPPA,UAP1,NUS1,DPM1,NEU3,GMPPB,ST6GALNAC1,ST6GALNAC6,ALG10B,ST6GAL1,ST6GALNAC5,GNE,MPI,ALG10,NPL,DPM3,PMM2,ST3GAL2,ST8SIA3,ST6GALNAC2,ST8SIA4,DOLK,ALG3,DOLPP1,ALG6,PGM3,FCSK,ST6GALNAC3,GLB1,ALG2,SLC35C1,ST3GAL6,ALG8,GFPT2,MVD,ALG5,ST8SIA6,SLC17A5,ST8SIA5,ST6GAL2,SRD5A3,GFPT1,MPDU1,ST3GAL3,NANS
R-HSA-70171	Glycolysis	0.651637625916732	-0.428266660034418	32	28	0.00309940225813593	9034	10285	5518,2821,3098,5516,5210,5313,5224,226,3101,5209,2023,5515,2027,229,2645,5214,26330,3099,7167,2597,5519,5232,5223,5208,2026,5528,5315,5211	PPP2R1A,GPI,HK1,PPP2CB,PFKFB4,PKLR,PGAM2,ALDOA,HK3,PFKFB3,ENO1,PPP2CA,ENO3,ALDOB,GCK,PFKP,GAPDHS,HK2,TPI1,GAPDH,PPP2R1B,PGK2,PGAM1,PFKFB2,ENO2,PPP2R5D,PKM,PFKL
R-HSA-70263	Gluconeogenesis	0.651637625916732	-0.428266660034418	32	28	0.00309940225813593	9034	10285	226,4191,5224,2023,6576,1468,2821,2203,2806,2026,5223,10165,5567,2805,7167,5105,5568,8789,8402,26330,229,2027,5232,4190,5091,2597,8604,5566	ALDOA,MDH2,PGAM2,ENO1,SLC25A1,SLC25A10,GPI,FBP1,GOT2,ENO2,PGAM1,SLC25A13,PRKACB,GOT1,TPI1,PCK1,PRKACG,FBP2,SLC25A11,GAPDHS,ALDOB,ENO3,PGK2,MDH1,PC,GAPDH,SLC25A12,PRKACA
R-HSA-68962	Activation of the pre-replicative complex	0.651637625916732	-0.428266660034418	32	28	0.00309940225813593	9034	10285	6118,4998,84515,8317,5427,8318,56655,4173,990,5001,4172,6117,23649,5558,4171,5000,55388,4175,23594,6119,81620,23595,4999,10926,1017,54107,4174,5557	RPA2,ORC1,MCM8,CDC7,POLE2,CDC45,POLE4,MCM4,CDC6,ORC5,MCM3,RPA1,POLA2,PRIM2,MCM2,ORC4,MCM10,MCM6,ORC6,RPA3,CDT1,ORC3,ORC2,DBF4,CDK2,POLE3,MCM5,PRIM1
R-HSA-3785653	Myoclonic epilepsy of Lafora	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	6233,7314,7311,2998,5507,7957,2997,2992,7316	RPS27A,UBB,UBA52,GYS2,PPP1R3C,EPM2A,GYS1,GYG1,UBC
R-HSA-418890	Role of second messengers in netrin-1 signaling	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	5335,5306,57113,7223,7220,7222,7225,1630,9423	PLCG1,PITPNA,TRPC7,TRPC4,TRPC1,TRPC3,TRPC6,DCC,NTN1
R-HSA-174437	Removal of the Flap Intermediate from the C-strand	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	6117,6119,5111,2237,57804,6118,10714,1763,5424	RPA1,RPA3,PCNA,FEN1,POLD4,RPA2,POLD3,DNA2,POLD1
R-HSA-5663084	Diseases of carbohydrate metabolism	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	7316,7957,2992,2997,5507,6233,7314,7311,2998	UBC,EPM2A,GYG1,GYS1,PPP1R3C,RPS27A,UBB,UBA52,GYS2
R-HSA-1300644	Interaction With The Zona Pellucida	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	11085,5016,2683,8748,7783,7784,8747,57829,2515	ADAM30,OVGP1,B4GALT1,ADAM20,ZP2,ZP3,ADAM21,ZP4,ADAM2
R-HSA-1660517	Synthesis of PIPs at the late endosome membrane	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	5289,9110,5286,9896,30849,8898,55697,200576,9108	PIK3C3,MTMR4,PIK3C2A,FIG4,PIK3R4,MTMR2,VAC14,PIKFYVE,MTMR7
R-HSA-111367	SLBP independent Processing of Histone Pre-mRNAs	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	84967,6628,134353,25888,22916,6635,4686,6637,6636	LSM10,SNRPB,LSM11,ZNF473,NCBP2,SNRPE,NCBP1,SNRPG,SNRPF
R-HSA-164940	Nef mediated downregulation of MHC class I complex cell surface expression	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	55690,164,1174,8907,567,3105,162,10053,130340	PACS1,AP1G1,AP1S1,AP1M1,B2M,HLA-A,AP1B1,AP1M2,AP1S3
R-HSA-70635	Urea cycle	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	384,435,162417,10166,57407,1373,383,445,83884	ARG2,ASL,NAGS,SLC25A15,NMRAL1,CPS1,ARG1,ASS1,SLC25A2
R-HSA-727802	Transport of nucleotide sugars	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	11046,100616124,347734,84912,55343,51000,23169,10559,23443	SLC35D2,MIR4647,SLC35B2,SLC35B4,SLC35C1,SLC35B3,SLC35D1,SLC35A1,SLC35A3
R-HSA-77286	mitochondrial fatty acid beta-oxidation of saturated fatty acids	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	3033,33,37,34,35,142827,3030,6296,3032	HADH,ACADL,ACADVL,ACADM,ACADS,ACSM6,HADHA,ACSM3,HADHB
R-HSA-2465910	MASTL Facilitates Mitotic Progression	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	891,983,10776,5518,2029,5516,5519,84930,5515	CCNB1,CDK1,ARPP19,PPP2R1A,ENSA,PPP2CB,PPP2R1B,MASTL,PPP2CA
R-HSA-419812	Calcitonin-like ligand receptors	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	10268,10203,10266,3375,799,797,133,10267,796	RAMP3,CALCRL,RAMP2,IAPP,CALCR,CALCB,ADM,RAMP1,CALCA
R-HSA-8868766	rRNA processing in the mitochondrion	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	60528,55178,387338,54931,79922,130916,9692,29960,51106	ELAC2,MRM3,NSUN4,TRMT10C,MRM1,MTERF4,PRORP,MRM2,TFB1M
R-HSA-6811555	PI5P Regulates TP53 Acetylation	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	5608,5305,79837,5300,7157,2033,100302237,8396,3622	MAP2K6,PIP4K2A,PIP4K2C,PIN1,TP53,EP300,MIR1281,PIP4K2B,ING2
R-HSA-139915	Activation of PUMA and translocation to mitochondria	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	7161,7159,27113,1869,7157,7029,23368,7027,8626	TP73,TP53BP2,BBC3,E2F1,TP53,TFDP2,PPP1R13B,TFDP1,TP63
R-HSA-112311	Neurotransmitter Clearance In The Synaptic Cleft	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	6532,1312,6580,43,6582,590,100616414,217,6531	SLC6A4,COMT,SLC22A1,ACHE,SLC22A2,BCHE,MIR4761,ALDH2,SLC6A3
R-HSA-193692	Regulated proteolysis of p75NTR	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	51107,83464,6868,4790,5970,5664,4804,23385,7189	APH1A,APH1B,ADAM17,NFKB1,RELA,PSEN2,NGFR,NCSTN,TRAF6
R-HSA-3229121	Glycogen storage diseases	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	7316,7957,2992,2997,5507,6233,7314,7311,2998	UBC,EPM2A,GYG1,GYS1,PPP1R3C,RPS27A,UBB,UBA52,GYS2
R-HSA-168799	Neurotoxicity of clostridium toxins	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	22987,6843,6844,6857,127833,9900,9899,112755,6616	SV2C,VAMP1,VAMP2,SYT1,SYT2,SV2A,SV2B,STX1B,SNAP25
R-HSA-167590	Nef Mediated CD4 Down-regulation	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	1173,920,161,160,375,163,1175,51606,3932	AP2M1,CD4,AP2A2,AP2A1,ARF1,AP2B1,AP2S1,ATP6V1H,LCK
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	0.651916937260718	-0.42783812201054	10	9	0.000996236440115121	9034	10285	10454,7189,7316,7311,7314,6233,3656,6885,23118	TAB1,TRAF6,UBC,UBA52,UBB,RPS27A,IRAK2,MAP3K7,TAB2
R-HSA-72306	tRNA processing	0.654370021389291	-0.424082305578384	109	95	0.0105158290901041	9034	10285	55644,81890,79897,79023,91801,55687,9688,55706,2058,90353,11260,57604,54482,100101267,23165,54802,53371,51002,283742,55039,10898,79074,54931,127253,79691,4927,129450,81605,54913,23536,11102,81929,115708,129401,7175,80746,1787,10799,348995,10785,55253,51493,79902,116461,1653,283989,10556,112858,84705,10248,5901,93587,11097,9818,54888,5903,54517,152992,55621,23511,60487,23279,221078,51504,51367,23225,9972,10940,51605,57570,8021,9883,54901,80324,9631,55006,54920,8086,51637,4928,348180,9692,25821,10762,23636,339487,10978,10775,60528,51095,113179,54974,55746,134637,57122	OSGEP,QTRT1,RPP21,NUP37,ALKBH8,TRMU,NUP93,NDC1,EPRS1,CTU1,XPOT,TRMT9B,TRMT13,POM121C,NUP205,TRIT1,NUP54,TPRKB,FAM98B,TRMT12,CPSF4,C2orf49,TRMT10C,TYW3,QTRT2,NUP88,TYW5,URM1,RPP25,ADAT1,RPP14,SEH1L,TRMT61A,NUP35,TPR,TSEN2,TRDMT1,RPP40,NUP43,WDR4,TYW1,RTCB,NUP85,TSEN15,DDX1,TSEN54,RPP30,TP53RK,GTPBP3,POP7,RAN,TRMT10A,NUP42,NUP58,NSUN2,RANBP2,PUS7,TRMT44,TRMT1,NUP188,TRMT11,NUP160,NSUN6,TRMT112,POP5,NUP210,NUP153,POP1,TRMT6,TRMT5,NUP214,POM121,CDKAL1,PUS1,NUP155,TRMT61B,DUS2,AAAS,RTRAF,NUP98,CTU2,PRORP,MTO1,NUP50,NUP62,ZBTB8OS,CLP1,POP4,ELAC2,TRNT1,ADAT3,THG1L,NUP133,ADAT2,NUP107
R-HSA-5658442	Regulation of RAS by GAPs	0.655817992847295	-0.421871978462304	70	61	0.00675226920522471	9034	10285	23198,5713,9978,64926,7979,7316,153090,143471,5710,4893,122706,5684,7311,5692,5699,9491,5700,10197,5701,5718,161742,6233,5921,5707,5711,5708,5694,200734,9861,84078,3265,5715,5682,5717,5706,100847012,7314,5687,5685,5719,5922,5693,9462,399473,5690,4763,3845,5686,5702,5714,8831,5691,5695,8437,5704,8452,10156,5698,10213,5696,5720	PSME4,PSMD7,RBX1,RASAL3,SEM1,UBC,DAB2IP,PSMA8,PSMD4,NRAS,PSMB11,PSMA3,UBA52,PSMB4,PSMB10,PSMF1,PSMC1,PSME3,PSMC2,PSMD12,SPRED1,RPS27A,RASA1,PSMD1,PSMD5,PSMD2,PSMB6,SPRED2,PSMD6,KBTBD7,HRAS,PSMD9,PSMA1,PSMD11,PSMC6,MIR5004,UBB,PSMA6,PSMA4,PSMD13,RASA2,PSMB5,RASAL2,SPRED3,PSMB2,NF1,KRAS,PSMA5,PSMC3,PSMD8,SYNGAP1,PSMB3,PSMB7,RASAL1,PSMC4,CUL3,RASA4,PSMB9,PSMD14,PSMB8,PSME1
R-HSA-373760	L1CAM interactions	0.65691641455498	-0.42019849149062	101	88	0.00974097852557007	9034	10285	7430,8986,1785,6323,5058,6711,5605,4897,4684,3688,23114,26052,3673,1739,6386,5595,2260,6328,1175,214,6334,6329,288,1457,6714,1463,2048,286,6900,1759,2596,3312,161,1213,57698,287,1211,6331,284217,27255,3674,3785,1808,3685,1173,3690,6332,6708,10752,10048,3786,3915,8828,6326,7410,9252,6710,6327,1459,3680,6456,55800,57731,1272,6196,160,5604,6330,3672,11313,6195,5879,1956,6335,51332,3912,6712,1742,8650,6336,11280,8829,5594,8515,285643,6709,5962,163	EZR,RPS6KA4,DNM2,SCN1A,PAK1,SPTBN1,MAP2K2,NRCAM,NCAM1,ITGB1,NFASC,DNM3,ITGA2,DLG1,SDCBP,MAPK3,FGFR1,SCN3A,AP2S1,ALCAM,SCN8A,SCN4A,ANK3,CSNK2A1,SRC,NCAN,EPHB2,ANK1,CNTN2,DNM1,GAP43,HSPA8,AP2A2,CLTC,SHTN1,ANK2,CLTA,SCN5A,LAMA1,CNTN6,ITGA2B,KCNQ2,DPYSL2,ITGAV,AP2M1,ITGB3,SCN7A,SPTA1,CHL1,RANBP9,KCNQ3,LAMC1,NRP2,SCN2A,VAV2,RPS6KA5,SPTB,SCN2B,CSNK2A2,ITGA9,SH3GL2,SCN3B,SPTBN4,CNTN1,RPS6KA2,AP2A1,MAP2K1,SCN4B,ITGA1,LYPLA2,RPS6KA1,RAC1,EGFR,SCN9A,SPTBN5,LAMB1,SPTBN2,DLG4,NUMB,SCN10A,SCN11A,NRP1,MAPK1,ITGA10,KIF4B,SPTAN1,RDX,AP2B1
R-HSA-416993	Trafficking of GluR2-containing AMPA receptors	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	160,80852,2891,9463,23426,1173,4905,1175,5578,161,163,2890,2893,5582,5579	AP2A1,GRIP2,GRIA2,PICK1,GRIP1,AP2M1,NSF,AP2S1,PRKCA,AP2A2,AP2B1,GRIA1,GRIA4,PRKCG,PRKCB
R-HSA-139853	Elevation of cytosolic Ca2+ levels	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	3708,6786,84876,5026,57113,5023,5024,7225,3709,5025,5027,7222,3710,100616453,80228	ITPR1,STIM1,ORAI1,P2RX5,TRPC7,P2RX1,P2RX3,TRPC6,ITPR2,P2RX4,P2RX7,TRPC3,ITPR3,MIR4687,ORAI2
R-HSA-189445	Metabolism of porphyrins	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	644,3162,54657,1355,1371,2235,211,3163,54658,5498,7389,7390,1352,3145,210	BLVRA,HMOX1,UGT1A4,COX15,CPOX,FECH,ALAS1,HMOX2,UGT1A1,PPOX,UROD,UROS,COX10,HMBS,ALAD
R-HSA-193639	p75NTR signals via NF-kB	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	7311,8767,7189,4804,4803,5970,7314,6233,7316,4615,5584,3551,4792,8878,4790	UBA52,RIPK2,TRAF6,NGFR,NGF,RELA,UBB,RPS27A,UBC,MYD88,PRKCI,IKBKB,NFKBIA,SQSTM1,NFKB1
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	79646,8875,5168,5169,60490,8034,55229,2194,8876,53354,80025,60496,5167,8884,79717	PANK3,VNN2,ENPP2,ENPP3,PPCDC,SLC25A16,PANK4,FASN,VNN1,PANK1,PANK2,AASDHPPT,ENPP1,SLC5A6,PPCS
R-HSA-438066	Unblocking of NMDA receptor, glutamate binding and activation	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	4747,2893,2890,816,10142,2905,88,2891,2903,2904,1742,2906,818,817,815	NEFL,GRIA4,GRIA1,CAMK2B,AKAP9,GRIN2C,ACTN2,GRIA2,GRIN2A,GRIN2B,DLG4,GRIN2D,CAMK2G,CAMK2D,CAMK2A
R-HSA-264642	Acetylcholine Neurotransmitter Release Cycle	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	8500,8541,10815,8497,60482,6844,6812,22999,6857,10497,9256,8499,6616,5864,1103	PPFIA1,PPFIA3,CPLX1,PPFIA4,SLC5A7,VAMP2,STXBP1,RIMS1,SYT1,UNC13B,TSPOAP1,PPFIA2,SNAP25,RAB3A,CHAT
R-HSA-937072	TRAF6 mediated induction of TAK1 complex	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	353376,7189,10454,7099,23118,7098,7311,7316,148022,6885,929,23643,3656,6233,7314	TICAM2,TRAF6,TAB1,TLR4,TAB2,TLR3,UBA52,UBC,TICAM1,MAP3K7,CD14,LY96,IRAK2,RPS27A,UBB
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	7316,7048,57530,56288,2280,7046,7040,5590,387,6233,7314,23370,57154,50848,7311	UBC,TGFBR2,CGN,PARD3,FKBP1A,TGFBR1,TGFB1,PRKCZ,RHOA,RPS27A,UBB,ARHGEF18,SMURF1,F11R,UBA52
R-HSA-196299	Beta-catenin phosphorylation cascade	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	10023,2932,5528,5529,5515,5526,1452,1499,5518,5525,5519,8312,5516,5527,324	FRAT1,GSK3B,PPP2R5D,PPP2R5E,PPP2CA,PPP2R5B,CSNK1A1,CTNNB1,PPP2R1A,PPP2R5A,PPP2R1B,AXIN1,PPP2CB,PPP2R5C,APC
R-HSA-3232118	SUMOylation of transcription factors	0.657492025483444	-0.419322643546059	17	15	0.00166039406685853	9034	10285	8554,7021,6670,7157,51588,6613,7158,7020,6612,7022,1029,7341,4286,7329,4193	PIAS1,TFAP2B,SP3,TP53,PIAS4,SUMO2,TP53BP1,TFAP2A,SUMO3,TFAP2C,CDKN2A,SUMO1,MITF,UBE2I,MDM2
R-HSA-114608	Platelet degranulation	0.660887393052995	-0.414171812110583	132	115	0.0127296878459154	9034	10285	967,51571,3481,334,2162,5874,1950,5099,1521,801,3827,7043,22915,23052,5175,5005,83706,5552,5660,335,710,6813,29106,5196,7423,10257,6414,12,22927,55664,5478,3479,1191,5345,7277,350,7424,3959,88,5340,9749,78991,9948,808,3273,1072,2153,3690,5154,51706,2335,813,10184,7044,10447,197,7078,1893,7873,54676,7040,6647,5265,213,2,7450,5627,5267,308,5768,3674,374354,8407,7057,87,10490,2244,29789,7414,27154,5155,3309,3700,6678,928,3699,5054,66005,6403,81,51368,948,7123,1675,10487,2243,351,3671,3082,805,7042,7018,226,5341,2266,5216,259215,51097,7273,6694,135228,7422,54495,5004,5919	CD63,CYRIB,IGF2,APLP2,F13A1,RAB27B,EGF,PCDH7,CTSW,CALM1,KNG1,TGFB3,MMRN1,ENDOD1,PECAM1,ORM2,FERMT3,SRGN,PSAP,APOA1,SERPING1,STXBP2,SCG3,PF4,VEGFB,ABCC4,SELENOP,SERPINA3,HABP4,CDC37L1,PPIA,IGF1,CLU,SERPINF2,TUBA4A,APOH,VEGFC,LGALS3BP,ACTN2,PLG,PHACTR2,PCYOX1L,WDR1,CALM3,HRG,CFL1,F5,ITGB3,PDGFA,CYB5R1,FN1,CALU,LHFPL2,LEFTY2,FAM3C,AHSG,TIMP3,ECM1,MANF,GTPBP2,TGFB1,SOD1,SERPINA1,ALB,A2M,VWF,PROS1,SERPINA4,ANXA5,QSOX1,ITGA2B,NHLRC2,TAGLN2,THBS1,ACTN1,VTI1B,FGB,OLA1,VCL,BRPF3,PDGFB,HSPA5,ITIH4,SPARC,CD9,ITIH3,SERPINE1,CHID1,SELP,ACTN4,TEX264,CD36,CLEC3B,CFD,CAP1,FGA,APP,ISLR,HGF,CALM2,TGFB2,TF,ALDOA,PLEK,FGG,PFN1,LY6G6F,SCCPDH,TTN,SPP2,CD109,VEGFA,TMX3,ORM1,RARRES2
R-HSA-8852135	Protein ubiquitination	0.660984136088113	-0.414025439285149	62	54	0.00597741864069072	9034	10285	7320,9781,7323,9646,8344,54623,8915,7332,7314,7326,7347,3093,7328,23168,55236,7327,56254,7321,7334,90268,9810,5591,8346,7322,3017,7311,65264,51322,54926,8348,10477,8345,8347,92912,7316,10670,79577,3018,8341,220441,55284,8340,123169,997,11065,29089,7874,7324,8970,8343,51255,8339,8078,6233	UBE2B,RNF144A,UBE2D3,CTR9,H2BC6,PAF1,BCL10,UBE2L3,UBB,UBE2G1,UCHL3,UBE2K,UBE2H,RTF1,UBA6,UBE2G2,RNF20,UBE2D1,UBE2N,OTULIN,RNF40,PRKDC,H2BC10,UBE2D2,H2BC5,UBA52,UBE2Z,WAC,UBE2R2,H2BC17,UBE2E3,H2BC9,H2BC4,UBE2Q2,UBC,RRAGA,CDC73,H2BC3,H2BC15,RNF152,UBE2W,H2BC13,LEO1,CDC34,UBE2C,UBE2T,USP7,UBE2E1,H2BC11,H2BC7,RNF181,H2BC8,USP5,RPS27A
R-HSA-1236974	ER-Phagosome pathway	0.663412738475581	-0.410357950851335	85	74	0.0081912773965021	9034	10285	23480,6891,4615,7979,7316,5713,23198,811,143471,5710,5684,122706,9341,9491,948,5700,10197,5692,10333,5699,7311,5718,5701,5707,55176,23643,10952,6233,3134,5694,9861,5708,5711,7099,5717,1147,5706,5715,5682,6890,3105,3107,567,7097,5685,5719,5687,929,7314,3133,5693,3106,7096,5702,9554,5686,8773,5690,8673,3136,5691,5714,3551,6810,5695,29927,5698,3135,5704,5720,114609,10213,5696,6892	SEC61G,TAP2,MYD88,SEM1,UBC,PSMD7,PSME4,CALR,PSMA8,PSMD4,PSMA3,PSMB11,VAMP3,PSMF1,CD36,PSMC1,PSME3,PSMB4,TLR6,PSMB10,UBA52,PSMD12,PSMC2,PSMD1,SEC61A2,LY96,SEC61B,RPS27A,HLA-F,PSMB6,PSMD6,PSMD2,PSMD5,TLR4,PSMD11,CHUK,PSMC6,PSMD9,PSMA1,TAP1,HLA-A,HLA-C,B2M,TLR2,PSMA4,PSMD13,PSMA6,CD14,UBB,HLA-E,PSMB5,HLA-B,TLR1,PSMC3,SEC22B,PSMA5,SNAP23,PSMB2,VAMP8,HLA-H,PSMB3,PSMD8,IKBKB,STX4,PSMB7,SEC61A1,PSMB9,HLA-G,PSMC4,PSME1,TIRAP,PSMD14,PSMB8,TAPBP
R-HSA-140877	Formation of Fibrin Clot (Clotting Cascade)	0.664215604405594	-0.409148476780991	39	34	0.00376355988487934	9034	10285	5624,2160,2162,7056,2155,462,2149,2243,3827,5270,2,7450,5627,5197,10544,7035,2266,2814,3053,2244,2815,2165,5196,2159,5547,2152,2147,3818,2153,2811,710,5104,2161,5657	PROC,F11,F13A1,THBD,F7,SERPINC1,F2R,FGA,KNG1,SERPINE2,A2M,VWF,PROS1,PF4V1,PROCR,TFPI,FGG,GP5,SERPIND1,FGB,GP9,F13B,PF4,F10,PRCP,F3,F2,KLKB1,F5,GP1BA,SERPING1,SERPINA5,F12,PRTN3
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	0.664215604405594	-0.409148476780991	39	34	0.00376355988487934	9034	10285	7450,3717,5894,5594,5245,10256,1445,408,5037,3674,4140,2243,5595,3845,5908,4296,5906,4893,3690,5605,283455,8315,8826,673,409,2335,3265,7529,2244,6714,2266,54518,7414,5604	VWF,JAK2,RAF1,MAPK1,PHB1,CNKSR1,CSK,ARRB1,PEBP1,ITGA2B,MARK3,FGA,MAPK3,KRAS,RAP1B,MAP3K11,RAP1A,NRAS,ITGB3,MAP2K2,KSR2,BRAP,IQGAP1,BRAF,ARRB2,FN1,HRAS,YWHAB,FGB,SRC,FGG,APBB1IP,VCL,MAP2K1
R-HSA-5674135	MAP2K and MAPK activation	0.664215604405594	-0.409148476780991	39	34	0.00376355988487934	9034	10285	409,2335,3690,5605,8649,283455,8826,54756,673,54518,7414,5604,84292,3265,6714,7529,2244,2266,5594,10256,1445,408,3674,5037,4140,7450,5894,4893,5906,28956,2243,5595,3845,5908	ARRB2,FN1,ITGB3,MAP2K2,LAMTOR3,KSR2,IQGAP1,IL17RD,BRAF,APBB1IP,VCL,MAP2K1,WDR83,HRAS,SRC,YWHAB,FGB,FGG,MAPK1,CNKSR1,CSK,ARRB1,ITGA2B,PEBP1,MARK3,VWF,RAF1,NRAS,RAP1A,LAMTOR2,FGA,MAPK3,KRAS,RAP1B
R-HSA-6783310	Fanconi Anemia Pathway	0.664215604405594	-0.409148476780991	39	34	0.00376355988487934	9034	10285	146956,7398,353497,7311,55215,57697,2175,2177,2178,6119,55120,7314,2189,64858,7316,84464,2176,84126,6117,29089,80233,9937,2188,6233,201254,22909,199990,2067,545,197342,2072,6118,91442,27033	EME1,USP1,POLN,UBA52,FANCI,FANCM,FANCA,FANCD2,FANCE,RPA3,FANCL,UBB,FANCG,DCLRE1B,UBC,SLX4,FANCC,ATRIP,RPA1,UBE2T,FAAP100,DCLRE1A,FANCF,RPS27A,CENPX,FAN1,FAAP20,ERCC1,ATR,EME2,ERCC4,RPA2,FAAP24,ZBTB32
R-HSA-111465	Apoptotic cleavage of cellular proteins	0.664215604405594	-0.409148476780991	39	34	0.00376355988487934	9034	10285	118,1499,5580,2934,4001,6709,7431,63967,9414,2620,28988,324,1828,7082,2339,839,5747,100506658,22985,840,5588,1830,1832,329,836,5317,8428,841,4137,4000,1829,999,6304,5339	ADD1,CTNNB1,PRKCD,GSN,LMNB1,SPTAN1,VIM,CLSPN,TJP2,GAS2,DBNL,APC,DSG1,TJP1,FNTA,CASP6,PTK2,OCLN,ACIN1,CASP7,PRKCQ,DSG3,DSP,BIRC2,CASP3,PKP1,STK24,CASP8,MAPT,LMNA,DSG2,CDH1,SATB1,PLEC
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	0.664215604405594	-0.409148476780991	39	34	0.00376355988487934	9034	10285	409,2335,3690,5605,283455,8826,8315,673,54518,7414,5604,3265,6714,2244,7529,2266,5594,5245,10256,1445,408,5037,3674,4140,7450,3717,5894,4296,5906,4893,2243,5595,3845,5908	ARRB2,FN1,ITGB3,MAP2K2,KSR2,IQGAP1,BRAP,BRAF,APBB1IP,VCL,MAP2K1,HRAS,SRC,FGB,YWHAB,FGG,MAPK1,PHB1,CNKSR1,CSK,ARRB1,PEBP1,ITGA2B,MARK3,VWF,JAK2,RAF1,MAP3K11,RAP1A,NRAS,FGA,MAPK3,KRAS,RAP1B
R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	0.666918321231111	-0.405087697489846	24	21	0.00232455169360195	9034	10285	5982,56655,57804,5424,5423,54107,8505,142,6117,5983,5984,5985,6118,10714,6119,3978,5427,2237,5111,5981,10038	RFC2,POLE4,POLD4,POLD1,POLB,POLE3,PARG,PARP1,RPA1,RFC3,RFC4,RFC5,RPA2,POLD3,RPA3,LIG1,POLE2,FEN1,PCNA,RFC1,PARP2
R-HSA-174417	Telomere C-strand (Lagging Strand) Synthesis	0.666918321231111	-0.405087697489846	24	21	0.00232455169360195	9034	10285	3978,5427,6119,5981,5111,2237,5985,10714,6118,5558,6117,23649,5557,5984,5983,57804,56655,5982,1763,54107,5424	LIG1,POLE2,RPA3,RFC1,PCNA,FEN1,RFC5,POLD3,RPA2,PRIM2,RPA1,POLA2,PRIM1,RFC4,RFC3,POLD4,POLE4,RFC2,DNA2,POLE3,POLD1
R-HSA-170834	Signaling by TGF-beta Receptor Complex	0.667596653605819	-0.404071099780688	77	67	0.00741642683196812	9034	10285	56288,57530,6233,56937,23327,9611,3726,5590,4087,4088,25937,50848,1874,8812,1024,904,9958,1030,905,7316,892,25805,9110,6498,5045,2280,57154,7029,6497,7311,7027,7048,64750,4609,7514,1875,7321,5054,51592,5500,4221,7046,3065,142,7050,10273,4092,51377,11171,54778,5499,6667,387,7314,60436,5933,867,7040,5494,5501,22938,9612,23645,23370,7323,9372,4089	PARD3,CGN,RPS27A,PMEPA1,NEDD4L,NCOR1,JUNB,PRKCZ,SMAD2,SMAD3,WWTR1,F11R,E2F4,CCNK,CDK8,CCNT1,USP15,CDKN2B,CCNT2,UBC,CCNC,BAMBI,MTMR4,SKIL,FURIN,FKBP1A,SMURF1,TFDP2,SKI,UBA52,TFDP1,TGFBR2,SMURF2,MYC,XPO1,E2F5,UBE2D1,SERPINE1,TRIM33,PPP1CB,MEN1,TGFBR1,HDAC1,PARP1,TGIF1,STUB1,SMAD7,UCHL5,STRAP,RNF111,PPP1CA,SP1,RHOA,UBB,TGIF2,RBL1,CBL,TGFB1,PPM1A,PPP1CC,SNW1,NCOR2,PPP1R15A,ARHGEF18,UBE2D3,ZFYVE9,SMAD4
R-HSA-68867	Assembly of the pre-replicative complex	0.672633653114641	-0.396554446561542	69	60	0.00664157626743414	9034	10285	5690,5702,5686,5693,1870,7314,4175,4999,5685,23595,5719,81620,5687,5000,4171,10213,5696,5001,5720,5704,5698,990,4173,1871,5695,5714,84515,5691,5692,5699,7311,9491,10197,5700,5684,122706,4174,23594,143471,5710,23198,5713,7316,7979,4172,5717,5706,5715,5682,5708,5711,5694,9861,6233,5707,5718,4998,51053,5701,1869	PSMB2,PSMC3,PSMA5,PSMB5,E2F2,UBB,MCM6,ORC2,PSMA4,ORC3,PSMD13,CDT1,PSMA6,ORC4,MCM2,PSMD14,PSMB8,ORC5,PSME1,PSMC4,PSMB9,CDC6,MCM4,E2F3,PSMB7,PSMD8,MCM8,PSMB3,PSMB4,PSMB10,UBA52,PSMF1,PSME3,PSMC1,PSMA3,PSMB11,MCM5,ORC6,PSMA8,PSMD4,PSME4,PSMD7,UBC,SEM1,MCM3,PSMD11,PSMC6,PSMD9,PSMA1,PSMD2,PSMD5,PSMB6,PSMD6,RPS27A,PSMD1,PSMD12,ORC1,GMNN,PSMC2,E2F1
R-HSA-381119	Unfolded Protein Response (UPR)	0.674388775387543	-0.393948516283027	92	80	0.00885543502324552	9034	10285	11231,5611,9570,2673,118460,100500842,7494,11015,439,55062,8570,100500888,55176,5526,10952,7709,6347,1663,84447,4802,4189,1639,9820,9451,100137049,2931,3484,23480,37,811,5393,118,56915,22926,10113,5073,23404,55033,9695,56005,8720,9797,3309,467,6464,3576,2081,4000,1200,23016,27230,51726,9114,2137,22894,4801,3068,30827,10954,29927,10897,55738,22872,58477,4800,116138,7466,10130,11340,167227,6734,468,10525,440,7095,1965,10106,9709,6745,51010	SEC63,DNAJC3,GOSR2,GFPT1,EXOSC6,MIR3652,XBP1,KDELR3,GET3,WIPI1,KHSRP,MIR3940,SEC61A2,PPP2R5B,SEC61B,ZBTB17,CCL2,DDX11,SYVN1,NFYC,DNAJB9,DCTN1,CUL7,EIF2AK3,PLA2G4B,GSK3A,IGFBP1,SEC61G,ACADVL,CALR,EXOSC9,ADD1,EXOSC5,ATF6,PREB,PARN,EXOSC2,FKBP14,EDEM1,MYDGF,MBTPS1,TATDN2,HSPA5,ATF3,SHC1,CXCL8,ERN1,LMNA,TPP1,EXOSC7,SERP1,DNAJB11,ATP6V0D1,EXTL3,DIS3,NFYB,HDGF,CXXC1,PDIA5,SEC61A1,YIF1A,ARFGAP1,SEC31A,SRPRB,NFYA,KLHDC3,WFS1,PDIA6,EXOSC8,DCP2,SRPRA,ATF4,HYOU1,ASNS,SEC62,EIF2S1,CTDSP2,HERPUD1,SSR1,EXOSC3
R-HSA-70614	Amino acid synthesis and interconversion (transamination)	0.676927032732995	-0.390191792184345	31	27	0.00298870932034536	9034	10285	27165,65263,374569,2806,2746,29920,10003,10955,443,2744,5831,4942,347735,5723,619189,2805,2752,2346,29968,883,219595,57515,84706,256987,5832,339896,440	GLS2,PYCR3,ASPG,GOT2,GLUD1,PYCR2,NAALAD2,SERINC3,ASPA,GLS,PYCR1,OAT,SERINC2,PSPH,SERINC4,GOT1,GLUL,FOLH1,PSAT1,KYAT1,FOLH1B,SERINC1,GPT2,SERINC5,ALDH18A1,GADL1,ASNS
R-HSA-77108	Utilization of Ketone Bodies	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	38,622,5019	ACAT1,BDH1,OXCT1
R-HSA-5627083	RHO GTPases regulate CFTR trafficking	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	57120,1080,23433	GOPC,CFTR,RHOQ
R-HSA-163282	Mitochondrial transcription initiation	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	64216,7019,5442	TFB2M,TFAM,POLRMT
R-HSA-428359	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	10643,10644,10642	IGF2BP3,IGF2BP2,IGF2BP1
R-HSA-190374	FGFR1c and Klotho ligand binding and activation	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	9365,8074,2260	KL,FGF23,FGFR1
R-HSA-265473	Trafficking of dietary sterols	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	29881,64240,64241	NPC1L1,ABCG5,ABCG8
R-HSA-5250958	Toxicity of botulinum toxin type B (BoNT/B)	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	6857,127833,6844	SYT1,SYT2,VAMP2
R-HSA-3311021	SMAD4 MH2 Domain Mutants in Cancer	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4088,4087,4089	SMAD3,SMAD2,SMAD4
R-HSA-5602680	MyD88 deficiency (TLR5)	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4615,51135,7100	MYD88,IRAK4,TLR5
R-HSA-5339700	TCF7L2 mutants don't bind CTBP	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	1488,6934,1487	CTBP2,TCF7L2,CTBP1
R-HSA-1368071	NR1D1 (REV-ERBA) represses gene expression	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	9572,9611,8841	NR1D1,NCOR1,HDAC3
R-HSA-193681	Ceramide signalling	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4804,4803,6610	NGFR,NGF,SMPD2
R-HSA-173599	Formation of the active cofactor, UDP-glucuronate	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	23169,7360,7358	SLC35D1,UGP2,UGDH
R-HSA-73927	Depurination	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4968,4350,4595	OGG1,MPG,MUTYH
R-HSA-3304347	Loss of Function of SMAD4 in Cancer	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4089,4087,4088	SMAD4,SMAD2,SMAD3
R-HSA-191647	c-src mediated regulation of Cx43 function and closure of gap junctions	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	6714,2697,7082	SRC,GJA1,TJP1
R-HSA-162699	Synthesis of dolichyl-phosphate mannose	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	54344,8813,8818	DPM3,DPM1,DPM2
R-HSA-964827	Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	10905,57134,4121	MAN1A2,MAN1C1,MAN1A1
R-HSA-110331	Cleavage of the damaged purine	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4595,4350,4968	MUTYH,MPG,OGG1
R-HSA-77305	Beta oxidation of palmitoyl-CoA to myristoyl-CoA	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	37,3030,3032	ACADVL,HADHA,HADHB
R-HSA-8875791	MET activates STAT3	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4233,6774,3082	MET,STAT3,HGF
R-HSA-392023	Adrenaline signalling through Alpha-2 adrenergic receptor	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	151,150,152	ADRA2B,ADRA2A,ADRA2C
R-HSA-1483248	Synthesis of PIPs at the ER membrane	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	55300,5297,22908	PI4K2B,PI4KA,SACM1L
R-HSA-5250989	Toxicity of botulinum toxin type G (BoNT/G)	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	6857,6843,6844	SYT1,VAMP1,VAMP2
R-HSA-844455	The NLRP1 inflammasome	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	596,22861,598	BCL2,NLRP1,BCL2L1
R-HSA-977442	GABA A (rho) receptor activation	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	2570,200959,2569	GABRR2,GABRR3,GABRR1
R-HSA-5653890	Lactose synthesis	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	2683,6513,3906	B4GALT1,SLC2A1,LALBA
R-HSA-165181	Inhibition of TSC complex formation by PKB	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	7248,208,7249	TSC1,AKT2,TSC2
R-HSA-2395516	Electron transport from NADPH to Ferredoxin	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	112812,2230,2232	FDX2,FDX1,FDXR
R-HSA-352238	Breakdown of the nuclear lamina	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4001,839,4000	LMNB1,CASP6,LMNA
R-HSA-170145	Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	8900,890,983	CCNA1,CCNA2,CDK1
R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	10089,9424,3775	KCNK7,KCNK6,KCNK1
R-HSA-444411	Rhesus glycoproteins mediate ammonium transport.	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	51458,6005,57127	RHCG,RHAG,RHBG
R-HSA-1296067	Potassium transport channels	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	3758,3773,3766	KCNJ1,KCNJ16,KCNJ10
R-HSA-2892245	POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	5460,79923,6657	POU5F1,NANOG,SOX2
R-HSA-350864	Regulation of thyroid hormone activity	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	1735,1734,1733	DIO3,DIO2,DIO1
R-HSA-77285	Beta oxidation of myristoyl-CoA to lauroyl-CoA	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	3030,3032,33	HADHA,HADHB,ACADL
R-HSA-177539	Autointegration results in viral DNA circles	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	11168,8815,3159	PSIP1,BANF1,HMGA1
R-HSA-139910	Activation of BMF and translocation to mitochondria	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	5599,140735,90427	MAPK8,DYNLL2,BMF
R-HSA-111446	Activation of BIM and translocation to mitochondria	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	8655,5599,10018	DYNLL1,MAPK8,BCL2L11
R-HSA-175567	Integration of viral DNA into host genomic DNA	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	11168,3159,8815	PSIP1,HMGA1,BANF1
R-HSA-5688031	Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	6439,7270,29080	SFTPB,TTF1,CCDC59
R-HSA-8853336	Signaling by plasma membrane FGFR1 fusions	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	2260,11160,9530	FGFR1,ERLIN2,BAG4
R-HSA-5602571	TRAF3 deficiency - HSE	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	148022,7098,7187	TICAM1,TLR3,TRAF3
R-HSA-198745	Signalling to STAT3	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4803,4914,6774	NGF,NTRK1,STAT3
R-HSA-5250992	Toxicity of botulinum toxin type E (BoNT/E)	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	9900,9899,6616	SV2A,SV2B,SNAP25
R-HSA-110330	Recognition and association of DNA glycosylase with site containing an affected purine	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	4595,4968,4350	MUTYH,OGG1,MPG
R-HSA-1234162	Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	2034,55662,3091	EPAS1,HIF1AN,HIF1A
R-HSA-5658034	HHAT G278V abrogates palmitoylation of Hh-Np	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	3549,6469,50846	IHH,SHH,DHH
R-HSA-5635851	GLI proteins bind promoters of Hh responsive genes to promote transcription	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	2736,2737,2735	GLI2,GLI3,GLI1
R-HSA-3359463	Defective CUBN causes hereditary megaloblastic anemia 1	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	81693,8029,2694	AMN,CUBN,CBLIF
R-HSA-217271	FMO oxidises nucleophiles	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	2326,2327,2328	FMO1,FMO2,FMO3
R-HSA-191650	Regulation of gap junction activity	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	6714,2697,7082	SRC,GJA1,TJP1
R-HSA-3249367	STAT6-mediated induction of chemokines	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	6778,29110,340061	STAT6,TBK1,STING1
R-HSA-964975	Vitamins B6 activation to pyridoxal phosphate	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	8566,316,55163	PDXK,AOX1,PNPO
R-HSA-111458	Formation of apoptosome	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	54205,317,842	CYCS,APAF1,CASP9
R-HSA-1299503	TWIK related potassium channel (TREK)	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	3776,54207,50801	KCNK2,KCNK10,KCNK4
R-HSA-3359462	Defective AMN causes hereditary megaloblastic anemia 1	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	2694,8029,81693	CBLIF,CUBN,AMN
R-HSA-8849472	PTK6 Down-Regulation	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	5753,6725,5770	PTK6,SRMS,PTPN1
R-HSA-6806664	Metabolism of vitamin K	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	154807,79001,29914	VKORC1L1,VKORC1,UBIAD1
R-HSA-844615	The AIM2 inflammasome	0.677656838893888	-0.389114256497123	3	3	0.000332078813371707	9034	10285	9447,29108,834	AIM2,PYCARD,CASP1
R-HSA-5610783	Degradation of GLI2 by the proteasome	0.678785901720284	-0.387449515253953	61	53	0.00586672570290016	9034	10285	7314,5719,5685,5687,5690,8454,5702,5686,5693,5695,2736,5714,2932,5691,5696,10213,5720,51684,5704,5698,6500,1452,5710,143471,9978,23198,5713,7316,7979,5699,5692,7311,10197,5700,9491,5684,122706,5567,6233,5707,5718,5701,5566,5706,5717,5682,5715,5708,8945,5711,9861,5568,5694	UBB,PSMD13,PSMA4,PSMA6,PSMB2,CUL1,PSMC3,PSMA5,PSMB5,PSMB7,GLI2,PSMD8,GSK3B,PSMB3,PSMB8,PSMD14,PSME1,SUFU,PSMC4,PSMB9,SKP1,CSNK1A1,PSMD4,PSMA8,RBX1,PSME4,PSMD7,UBC,SEM1,PSMB10,PSMB4,UBA52,PSME3,PSMC1,PSMF1,PSMA3,PSMB11,PRKACB,RPS27A,PSMD1,PSMD12,PSMC2,PRKACA,PSMC6,PSMD11,PSMA1,PSMD9,PSMD2,BTRC,PSMD5,PSMD6,PRKACG,PSMB6
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	0.678785901720284	-0.387449515253953	61	53	0.00586672570290016	9034	10285	7316,7979,9978,5713,23198,143471,5710,1452,5684,122706,9491,10197,5700,5692,5699,7311,5718,5701,5707,6233,5567,5694,5568,9861,5708,5711,8945,5717,5706,5715,5682,5566,5685,5719,5687,7314,5693,5702,8454,5686,5690,2932,5691,5714,5695,5698,6500,51684,5704,5720,10213,5696,2737	UBC,SEM1,RBX1,PSMD7,PSME4,PSMA8,PSMD4,CSNK1A1,PSMA3,PSMB11,PSMF1,PSME3,PSMC1,PSMB4,PSMB10,UBA52,PSMD12,PSMC2,PSMD1,RPS27A,PRKACB,PSMB6,PRKACG,PSMD6,PSMD2,PSMD5,BTRC,PSMD11,PSMC6,PSMD9,PSMA1,PRKACA,PSMA4,PSMD13,PSMA6,UBB,PSMB5,PSMC3,CUL1,PSMA5,PSMB2,GSK3B,PSMB3,PSMD8,PSMB7,PSMB9,SKP1,SUFU,PSMC4,PSME1,PSMD14,PSMB8,GLI3
R-HSA-5610780	Degradation of GLI1 by the proteasome	0.678785901720284	-0.387449515253953	61	53	0.00586672570290016	9034	10285	143471,5710,7979,7316,9978,23198,5713,9491,5700,10197,5692,5699,7311,5684,122706,5707,6233,5567,5718,5701,5717,5706,5715,5682,5566,5694,5568,9861,5708,5711,8945,5685,5719,5687,7314,5702,8454,5686,5690,8650,5693,5695,5691,5714,83737,5720,10213,2735,5696,5698,6500,51684,5704	PSMA8,PSMD4,SEM1,UBC,RBX1,PSME4,PSMD7,PSMF1,PSMC1,PSME3,PSMB4,PSMB10,UBA52,PSMA3,PSMB11,PSMD1,RPS27A,PRKACB,PSMD12,PSMC2,PSMD11,PSMC6,PSMD9,PSMA1,PRKACA,PSMB6,PRKACG,PSMD6,PSMD2,PSMD5,BTRC,PSMA4,PSMD13,PSMA6,UBB,PSMC3,CUL1,PSMA5,PSMB2,NUMB,PSMB5,PSMB7,PSMB3,PSMD8,ITCH,PSME1,PSMD14,GLI1,PSMB8,PSMB9,SKP1,SUFU,PSMC4
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	0.678785901720284	-0.387449515253953	61	53	0.00586672570290016	9034	10285	23198,5713,7157,7316,7979,143471,5347,5710,51512,5684,122706,22919,5692,5699,7311,9491,10197,5700,5718,5701,9133,6233,5707,5708,5711,5694,9861,5717,5706,5715,5682,7314,5685,5719,5687,3320,983,5693,5690,5702,5686,63943,5714,5691,5695,3326,5704,1026,5698,891,10213,5696,5720	PSME4,PSMD7,TP53,UBC,SEM1,PSMA8,PLK1,PSMD4,GTSE1,PSMA3,PSMB11,MAPRE1,PSMB4,PSMB10,UBA52,PSMF1,PSME3,PSMC1,PSMD12,PSMC2,CCNB2,RPS27A,PSMD1,PSMD2,PSMD5,PSMB6,PSMD6,PSMD11,PSMC6,PSMD9,PSMA1,UBB,PSMA4,PSMD13,PSMA6,HSP90AA1,CDK1,PSMB5,PSMB2,PSMC3,PSMA5,FKBPL,PSMD8,PSMB3,PSMB7,HSP90AB1,PSMC4,CDKN1A,PSMB9,CCNB1,PSMD14,PSMB8,PSME1
R-HSA-69242	S Phase	0.68502832484419	-0.378295091437302	130	113	0.0125083019703343	9034	10285	5695,2237,10714,64785,890,4609,84515,5696,9837,8900,5704,6500,4175,113130,10274,5687,81620,5685,7465,51659,5000,9134,5690,5686,8454,5753,5982,5427,5701,902,5985,4172,6117,5715,5682,5717,23649,5708,84296,9861,56655,6502,23047,23594,143471,5710,23198,23244,4149,7316,7979,5692,9491,10197,5557,122706,1763,1017,54107,3978,5714,1027,1019,5691,5984,5001,10213,5720,1026,8318,5424,4331,4173,5698,990,7314,51343,6119,4999,23595,5719,993,4171,9126,5702,57804,5693,6233,5981,5111,595,5707,5925,6118,5718,4998,5706,5711,5694,5885,157570,994,5713,898,5558,5983,7311,5699,5700,1022,23063,5684,4174	PSMB7,FEN1,POLD3,GINS3,CCNA2,MYC,MCM8,PSMB8,GINS1,CCNA1,PSMC4,SKP1,MCM6,CDCA5,STAG1,PSMA6,CDT1,PSMA4,WEE1,GINS2,ORC4,CCNE2,PSMB2,PSMA5,CUL1,PTK6,RFC2,POLE2,PSMC2,CCNH,RFC5,MCM3,RPA1,PSMD9,PSMA1,PSMD11,POLA2,PSMD2,GINS4,PSMD6,POLE4,SKP2,PDS5B,ORC6,PSMA8,PSMD4,PSME4,PDS5A,MAX,UBC,SEM1,PSMB4,PSMF1,PSME3,PRIM1,PSMB11,DNA2,CDK2,POLE3,LIG1,PSMD8,CDKN1B,CDK4,PSMB3,RFC4,ORC5,PSMD14,PSME1,CDKN1A,CDC45,POLD1,MNAT1,MCM4,PSMB9,CDC6,UBB,FZR1,RPA3,ORC2,ORC3,PSMD13,CDC25A,MCM2,SMC3,PSMC3,POLD4,PSMB5,RPS27A,RFC1,PCNA,CCND1,PSMD1,RB1,RPA2,PSMD12,ORC1,PSMC6,PSMD5,PSMB6,RAD21,ESCO2,CDC25B,PSMD7,CCNE1,PRIM2,RFC3,UBA52,PSMB10,PSMC1,CDK7,WAPL,PSMA3,MCM5
R-HSA-5620920	Cargo trafficking to the periciliary membrane	0.686440296112145	-0.376236026074453	53	46	0.00509187513836617	9034	10285	403,9727,54536,5310,192668,55212,10640,27031,100616329,27241,50807,129880,8766,5147,166379,2847,6753,583,6010,1262,60412,8195,54585,5311,55770,84100,378,1258,582,55763,149371,4218,23265,22948,8729,585,79738,10576,84747,10694,123016,92482,117177,10575,6608,11336	ARL3,RAB11FIP3,EXOC6,PKD1,CYS1,BBS7,EXOC5,NPHP3,MIR4700,BBS9,ASAP1,BBS5,RAB11A,PDE6D,BBS12,MCHR1,SSTR3,BBS2,RHO,CNGA4,EXOC4,MKKS,LZTFL1,PKD2,EXOC2,ARL6,ARF4,CNGB1,BBS1,EXOC1,EXOC8,RAB8A,EXOC7,CCT5,GBF1,BBS4,BBS10,CCT2,UNC119B,CCT8,TTC8,BBIP1,RAB3IP,CCT4,SMO,EXOC3
R-HSA-373755	Semaphorin interactions	0.689277837237696	-0.372110842171347	68	59	0.00653088332964357	9034	10285	5062,3326,23129,5362,4627,4628,3672,9723,388,80031,5879,2932,91584,9037,5364,23365,56896,1020,3320,2909,2534,3985,8482,5788,1809,2242,389,387,103910,8829,64218,79784,1808,2064,10154,9826,1072,10398,27289,23396,5058,3688,4637,10371,8851,998,9475,6237,971,3984,391,1400,5361,57556,10507,4233,7305,5880,4629	PAK2,HSP90AB1,PLXND1,PLXNA2,MYH9,MYH10,ITGA1,SEMA3E,RHOB,SEMA6D,RAC1,GSK3B,PLXNA4,SEMA5A,PLXNB1,ARHGEF12,DPYSL5,CDK5,HSP90AA1,ARHGAP35,FYN,LIMK2,SEMA7A,PTPRC,DPYSL3,FES,RHOC,RHOA,MYL12B,NRP1,SEMA4A,MYH14,DPYSL2,ERBB2,PLXNC1,ARHGEF11,CFL1,MYL9,RND1,PIP5K1C,PAK1,ITGB1,MYL6,SEMA3A,CDK5R1,CDC42,ROCK2,RRAS,CD72,LIMK1,RHOG,CRMP1,PLXNA1,SEMA6A,SEMA4D,MET,TYROBP,RAC2,MYH11
R-HSA-1169091	Activation of NF-kappaB in B cells	0.689277837237696	-0.372110842171347	68	59	0.00653088332964357	9034	10285	23198,5713,7979,7316,143471,4794,5710,122706,5684,84433,7311,5692,5699,9491,10197,5700,5701,4792,5718,5966,6233,6885,23291,5707,5711,5970,8945,5708,5694,9861,5715,5682,5717,1147,5706,7314,5687,5685,5719,5693,5690,5686,8915,5702,8454,4790,5714,3551,5691,5695,5579,4793,5704,6500,5698,10213,5696,5720,10892	PSME4,PSMD7,SEM1,UBC,PSMA8,NFKBIE,PSMD4,PSMB11,PSMA3,CARD11,UBA52,PSMB4,PSMB10,PSMF1,PSME3,PSMC1,PSMC2,NFKBIA,PSMD12,REL,RPS27A,MAP3K7,FBXW11,PSMD1,PSMD5,RELA,BTRC,PSMD2,PSMB6,PSMD6,PSMD9,PSMA1,PSMD11,CHUK,PSMC6,UBB,PSMA6,PSMA4,PSMD13,PSMB5,PSMB2,PSMA5,BCL10,PSMC3,CUL1,NFKB1,PSMD8,IKBKB,PSMB3,PSMB7,PRKCB,NFKBIB,PSMC4,SKP1,PSMB9,PSMD14,PSMB8,PSME1,MALT1
R-HSA-446353	Cell-extracellular matrix interactions	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	55679,55742,29780,6251,10979,5829,3688,7016,54751,3611,7408,2318,87,3987	LIMS2,PARVA,PARVB,RSU1,FERMT2,PXN,ITGB1,TESK1,FBLIM1,ILK,VASP,FLNC,ACTN1,LIMS1
R-HSA-372708	p130Cas linkage to MAPK signaling for integrins	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	3674,2335,9564,3690,7450,54518,5747,5906,5908,2266,1398,2244,6714,2243	ITGA2B,FN1,BCAR1,ITGB3,VWF,APBB1IP,PTK2,RAP1A,RAP1B,FGG,CRK,FGB,SRC,FGA
R-HSA-5218859	Regulated Necrosis	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	11035,8772,8717,356,8737,841,355,329,8797,8743,8795,197259,8837,330	RIPK3,FADD,TRADD,FASLG,RIPK1,CASP8,FAS,BIRC2,TNFRSF10A,TNFSF10,TNFRSF10B,MLKL,CFLAR,BIRC3
R-HSA-399956	CRMPs in Sema3A signaling	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	2932,8829,1400,5361,2534,5362,1809,2242,8851,1020,56896,1808,91584,10371	GSK3B,NRP1,CRMP1,PLXNA1,FYN,PLXNA2,DPYSL3,FES,CDK5R1,CDK5,DPYSL5,DPYSL2,PLXNA4,SEMA3A
R-HSA-5213460	RIPK1-mediated regulated necrosis	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	8772,8717,356,8737,11035,841,8797,8743,8795,355,329,330,197259,8837	FADD,TRADD,FASLG,RIPK1,RIPK3,CASP8,TNFRSF10A,TNFSF10,TNFRSF10B,FAS,BIRC2,BIRC3,MLKL,CFLAR
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	5908,2266,2244,2243,6714,54518,5747,2885,5906,6654,3690,7450,3674,2335	RAP1B,FGG,FGB,FGA,SRC,APBB1IP,PTK2,GRB2,RAP1A,SOS1,ITGB3,VWF,ITGA2B,FN1
R-HSA-1170546	Prolactin receptor signaling	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	5781,6776,5618,9978,3717,25970,6777,2688,6500,8945,8454,2690,1444,5617	PTPN11,STAT5A,PRLR,RBX1,JAK2,SH2B1,STAT5B,GH1,SKP1,BTRC,CUL1,GHR,CSHL1,PRL
R-HSA-399954	Sema3A PAK dependent Axon repulsion	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	2534,5362,2242,1072,5062,3320,3326,91584,10371,5879,8829,3984,5058,5361	FYN,PLXNA2,FES,CFL1,PAK2,HSP90AA1,HSP90AB1,PLXNA4,SEMA3A,RAC1,NRP1,LIMK1,PAK1,PLXNA1
R-HSA-163210	Formation of ATP by chemiosmotic coupling	0.692658443819843	-0.367218267351466	16	14	0.00154970112906797	9034	10285	514,10632,506,27109,516,513,498,522,518,539,509,10476,515,517	ATP5F1E,ATP5MG,ATP5F1B,DMAC2L,ATP5MC1,ATP5F1D,ATP5F1A,ATP5PF,ATP5MC3,ATP5PO,ATP5F1C,ATP5PD,ATP5PB,ATP5MC2
R-HSA-453274	Mitotic G2-G2/M phases	0.692664058362743	-0.367210161595744	184	160	0.017710870046491	9034	10285	7314,1063,7846,10121,5515,5719,9793,9702,54930,993,22994,23194,5516,5702,11190,728642,5693,55125,7532,7840,1871,10426,10540,5714,63943,5691,7514,10213,5720,11064,80028,1026,4331,23332,79959,891,55755,5698,23354,994,4926,121441,95681,5713,9978,55722,7311,91750,5699,114791,1639,5577,5700,2033,1022,5684,5048,4605,85378,6233,22981,5707,1869,5718,79866,22822,10142,93323,5566,4957,5706,3161,5711,22897,995,5694,132660,5687,5685,7465,84131,6790,10382,1453,5690,80184,4751,5686,8454,100302237,5518,4660,3320,11258,983,10733,5695,55835,5500,55957,890,8655,84962,5696,8900,286826,5704,3326,6500,7277,5520,5710,4218,5347,143471,9814,7157,22995,23198,203068,7979,1778,7316,984,5692,10197,9491,122706,80321,51512,1017,9088,7531,22919,54820,5108,23291,5701,902,9133,1454,4659,10133,79441,5682,5519,5715,5928,5717,8945,9662,27175,1781,5708,54801,9861,22974,80254,115106,10806	UBB,CENPF,TUBA1A,ACTR1A,PPP2CA,PSMD13,CKAP5,CEP57,HAUS4,CDC25A,CEP131,FBXL7,PPP2CB,PSMC3,CEP250,CDK11A,PSMB5,CEP192,YWHAG,ALMS1,E2F3,TUBGCP3,DCTN2,PSMD8,FKBPL,PSMB3,XPO1,PSMD14,PSME1,CNTRL,FBXL18,CDKN1A,MNAT1,CLASP1,CEP76,CCNB1,CDK5RAP2,PSMB9,HAUS5,CDC25B,NUMA1,NEDD1,CEP41,PSMD7,RBX1,CEP72,UBA52,LIN52,PSMB10,TUBGCP5,DCTN1,PRKAR2B,PSMC1,EP300,CDK7,PSMA3,PAFAH1B1,MYBL2,TUBGCP6,RPS27A,NINL,PSMD1,E2F1,PSMD12,BORA,PHLDA1,AKAP9,HAUS8,PRKACA,ODF2,PSMC6,HMMR,PSMD5,CEP164,CDC25C,PSMB6,LIN54,PSMA6,PSMA4,WEE1,CEP78,AURKA,TUBB4A,CSNK1D,PSMB2,CEP290,NEK2,PSMA5,CUL1,MIR1281,PPP2R1A,PPP1R12B,HSP90AA1,DCTN3,CDK1,PLK4,PSMB7,CENPJ,PPP1CB,LIN37,CCNA2,DYNLL1,AJUBA,PSMB8,CCNA1,LIN9,PSMC4,HSP90AB1,SKP1,TUBA4A,PPP2R2A,PSMD4,RAB8A,PLK1,PSMA8,SFI1,TP53,CEP152,PSME4,TUBB,SEM1,DYNC1H1,UBC,CDK11B,PSMB4,PSME3,PSMF1,PSMB11,CEP70,GTSE1,CDK2,PKMYT1,YWHAE,MAPRE1,NDE1,PCM1,FBXW11,PSMC2,CCNH,CCNB2,CSNK1E,PPP1R12A,OPTN,HAUS3,PSMA1,PPP2R1B,PSMD9,RBBP4,PSMD11,BTRC,CEP135,TUBG2,DYNC1I2,PSMD2,HAUS6,PSMD6,TPX2,CEP63,HAUS1,SDCCAG8
R-HSA-73980	RNA Polymerase III Transcription Termination	0.695917405212121	-0.362524296361879	23	20	0.00221385875581138	9034	10285	661,4784,9533,4774,10622,51082,5434,5440,4782,55718,6741,27297,171568,84265,4781,55703,5441,10623,51728,11128	POLR3D,NFIX,POLR1C,NFIA,POLR3G,POLR1D,POLR2E,POLR2K,NFIC,POLR3E,SSB,CRCP,POLR3H,POLR3GL,NFIB,POLR3B,POLR2L,POLR3C,POLR3K,POLR3A
R-HSA-389977	Post-chaperonin tubulin folding pathway	0.695917405212121	-0.362524296361879	23	20	0.00221385875581138	9034	10285	1155,347733,402,84790,84617,6903,10382,6904,10381,6902,7846,79861,7277,10376,81027,7278,6905,112714,7280,51807	TBCB,TUBB2B,ARL2,TUBA1C,TUBB6,TBCC,TUBB4A,TBCD,TUBB3,TBCA,TUBA1A,TUBAL3,TUBA4A,TUBA1B,TUBB1,TUBA3C,TBCE,TUBA3E,TUBB2A,TUBA8
R-HSA-379726	Mitochondrial tRNA aminoacylation	0.695917405212121	-0.362524296361879	23	20	0.00221385875581138	9034	10285	2617,23395,57176,10667,10352,55699,51067,92935,57505,79587,124454,27068,3735,25973,54938,57038,79731,5859,80222,23438	GARS1,LARS2,VARS2,FARS2,WARS2,IARS2,YARS2,MARS2,AARS2,CARS2,EARS2,PPA2,KARS1,PARS2,SARS2,RARS2,NARS2,QARS1,TARS2,HARS2
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	0.695917405212121	-0.362524296361879	23	20	0.00221385875581138	9034	10285	7311,11065,51434,7324,29945,891,64682,983,10393,6233,7314,25906,7321,51433,119504,996,8697,991,7316,51529	UBA52,UBE2C,ANAPC7,UBE2E1,ANAPC4,CCNB1,ANAPC1,CDK1,ANAPC10,RPS27A,UBB,ANAPC15,UBE2D1,ANAPC5,ANAPC16,CDC27,CDC23,CDC20,UBC,ANAPC11
R-HSA-6811438	Intra-Golgi traffic	0.696195817105719	-0.362124311801936	45	39	0.00431702457383219	9034	10285	9527,25839,4121,10228,8675,83452,9950,63908,57134,9570,57589,4124,375,1523,91949,9382,4905,8774,51272,9321,9266,84342,9609,22796,57511,10466,27333,250,11311,9267,6811,83548,9265,10905,27314,4122,10652,27128,54734	GOSR1,COG4,MAN1A1,STX6,STX16,RAB33B,GOLGA5,NAPB,MAN1C1,GOSR2,RIC1,MAN2A1,ARF1,CUX1,COG7,COG1,NSF,NAPG,BET1L,TRIP11,CYTH2,COG8,RAB36,COG2,COG6,COG5,GOLIM4,ALPP,VPS45,CYTH1,STX5,COG3,CYTH3,MAN1A2,RAB30,MAN2A2,YKT6,CYTH4,RAB39A
R-HSA-6784531	tRNA processing in the nucleus	0.69639174792645	-0.3618429207757	60	52	0.00575603276510959	9034	10285	10898,51367,53371,283742,23225,9972,10940,23511,23279,5903,100101267,23165,11260,9818,10248,5901,9688,55706,11097,79023,79897,1653,283989,55746,10556,57122,10775,60528,51493,116461,79902,51095,339487,10799,348995,10978,10762,23636,51637,129401,4928,7175,80746,11102,9631,81929,8086,8021,9883,54913,79074,4927	CPSF4,POP5,NUP54,FAM98B,NUP210,NUP153,POP1,NUP188,NUP160,RANBP2,POM121C,NUP205,XPOT,NUP58,POP7,RAN,NUP93,NDC1,NUP42,NUP37,RPP21,DDX1,TSEN54,NUP133,RPP30,NUP107,POP4,ELAC2,RTCB,TSEN15,NUP85,TRNT1,ZBTB8OS,RPP40,NUP43,CLP1,NUP50,NUP62,RTRAF,NUP35,NUP98,TPR,TSEN2,RPP14,NUP155,SEH1L,AAAS,NUP214,POM121,RPP25,C2orf49,NUP88
R-HSA-68827	CDT1 association with the CDC6:ORC:origin complex	0.69639174792645	-0.3618429207757	60	52	0.00575603276510959	9034	10285	7314,5685,4999,23595,5719,5687,81620,5000,5690,5702,5686,5693,5695,5714,84515,5691,5696,10213,5001,5720,5704,990,5698,23594,5710,143471,23198,5713,7316,7979,5699,5692,7311,5700,10197,9491,5684,122706,6233,5707,51053,4998,5718,5701,5706,5717,5682,5715,5708,5711,9861,5694	UBB,PSMA4,ORC2,ORC3,PSMD13,PSMA6,CDT1,ORC4,PSMB2,PSMC3,PSMA5,PSMB5,PSMB7,PSMD8,MCM8,PSMB3,PSMB8,PSMD14,ORC5,PSME1,PSMC4,CDC6,PSMB9,ORC6,PSMD4,PSMA8,PSME4,PSMD7,UBC,SEM1,PSMB10,PSMB4,UBA52,PSMC1,PSME3,PSMF1,PSMA3,PSMB11,RPS27A,PSMD1,GMNN,ORC1,PSMD12,PSMC2,PSMC6,PSMD11,PSMA1,PSMD9,PSMD2,PSMD5,PSMD6,PSMB6
R-HSA-74182	Ketone body metabolism	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	54511,56898,38,622,65985,3155,5019,79611	HMGCLL1,BDH2,ACAT1,BDH1,AACS,HMGCL,OXCT1,ACSS3
R-HSA-428543	Inactivation of Cdc42 and Rac	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	23380,2817,57522,5879,998,9901,6091,9353	SRGAP2,GPC1,SRGAP1,RAC1,CDC42,SRGAP3,ROBO1,SLIT2
R-HSA-1462054	Alpha-defensins	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	1671,417,5646,1669,728358,1667,920,1670	DEFA6,ART1,PRSS3,DEFA4,DEFA1B,DEFA1,CD4,DEFA5
R-HSA-1296052	Ca2+ activated K+ channels	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	3782,3780,3779,27345,3778,27094,3781,10242	KCNN3,KCNN1,KCNMB1,KCNMB4,KCNMA1,KCNMB3,KCNN2,KCNMB2
R-HSA-5666185	RHO GTPases Activate Rhotekin and Rhophilins	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	388,114822,6242,54763,389,387,85415,30851	RHOB,RHPN1,RTKN,ROPN1,RHOC,RHOA,RHPN2,TAX1BP3
R-HSA-110357	Displacement of DNA glycosylase by APEX1	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	23583,8930,4350,7374,6996,4968,4913,4595	SMUG1,MBD4,MPG,UNG,TDG,OGG1,NTHL1,MUTYH
R-HSA-1614558	Degradation of cysteine and homocysteine	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	7263,1036,1468,58472,6821,1491,84890,51380	TST,CDO1,SLC25A10,SQOR,SUOX,CTH,ADO,CSAD
R-HSA-159424	Conjugation of carboxylic acids	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	341392,389396,348158,219970,10249,123876,116285,92292	ACSM4,GLYATL3,ACSM2B,GLYATL2,GLYAT,ACSM2A,ACSM1,GLYATL1
R-HSA-3304351	Signaling by TGF-beta Receptor Complex in Cancer	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	7048,4088,7046,4089,7040,4087,2280,9372	TGFBR2,SMAD3,TGFBR1,SMAD4,TGFB1,SMAD2,FKBP1A,ZFYVE9
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	760,3039,3043,762,358,759,6005,6521	CA2,HBA1,HBB,CA4,AQP1,CA1,RHAG,SLC4A1
R-HSA-71336	Pentose phosphate pathway (hexose monophosphate shunt)	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	22934,25796,55276,5226,6120,51071,6888,7086	RPIA,PGLS,PGM2,PGD,RPE,DERA,TALDO1,TKT
R-HSA-426486	Small interfering RNA (siRNA) biogenesis	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	23405,8575,27161,192669,7247,7257,26523,192670	DICER1,PRKRA,AGO2,AGO3,TSN,TSNAX,AGO1,AGO4
R-HSA-156587	Amino Acid conjugation	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	341392,389396,123876,10249,348158,219970,116285,92292	ACSM4,GLYATL3,ACSM2A,GLYAT,ACSM2B,GLYATL2,ACSM1,GLYATL1
R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	23479,2230,2232,57128,2395,81894,51312,112812	ISCU,FDX1,FDXR,LYRM4,FXN,SLC25A28,SLC25A37,FDX2
R-HSA-198693	AKT phosphorylates targets in the nucleus	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	6199,208,3164,2308,207,2309,1385,10000	RPS6KB2,AKT2,NR4A1,FOXO1,AKT1,FOXO3,CREB1,AKT3
R-HSA-5340588	RNF mutants show enhanced WNT signaling and proliferation	0.699119099284857	-0.357934166019244	9	8	0.000885543502324552	9034	10285	4041,8322,8325,8323,89780,4040,7855,54894	LRP5,FZD4,FZD8,FZD6,WNT3A,LRP6,FZD5,RNF43
R-HSA-162587	HIV Life Cycle	0.700419510822591	-0.356075822272835	152	132	0.0146114677883551	9034	10285	8812,23636,904,6749,10762,6921,6873,51652,6827,57122,1234,6881,55746,2962,902,9525,7936,2959,9883,8021,6883,5478,8086,5432,162699,9631,5045,920,51224,6923,7251,7316,5440,4928,3836,905,5903,6879,2068,2958,22916,79720,3159,23279,6884,23511,23225,9972,2237,6924,8178,10015,100302168,2960,8732,4686,2071,11198,6874,2967,2965,27183,11097,5430,4836,8815,5901,100506888,6917,2547,9818,7469,5441,11168,5902,348995,79902,9397,6233,23327,7518,100302242,5434,100126332,91782,4927,8731,1104,6880,404672,7311,128866,7852,1022,5439,25978,81929,51510,6877,79643,6875,92421,7175,129401,23165,100101267,7520,83860,55048,4331,5431,138474,3978,2963,53371,51534,7514,2957,6882,137492,2961,3981,9150,6829,79023,2968,55706,9688,7314,51497,5905,5433	CCNK,NUP62,CCNT1,SSRP1,NUP50,ELOC,TAF2,CHMP3,SUPT4H1,NUP107,CCR5,TAF10,NUP133,GTF2F1,CCNH,VPS4B,NELFE,GTF2B,POM121,NUP214,TAF12,PPIA,AAAS,POLR2C,ELOA3P,NUP155,FURIN,CD4,ELOA2,ELOB,TSG101,UBC,POLR2K,NUP98,KPNA1,CCNT2,RANBP2,TAF7,ERCC2,GTF2A2,NCBP2,VPS37B,HMGA1,NUP160,TAF13,NUP188,NUP210,NUP153,FEN1,ELOA,ELL,PDCD6IP,MIR1257,GTF2E1,RNGTT,NCBP1,ERCC3,SUPT16H,TAF4,GTF2H3,GTF2H1,VPS4A,NUP42,POLR2A,NMT1,BANF1,RAN,ELOA3DP,TCEA1,XRCC6,NUP58,NELFA,POLR2L,PSIP1,RANBP1,NUP43,NUP85,NMT2,RPS27A,NEDD4L,XRCC4,MIR1236,POLR2E,MIR943,CHMP7,NUP88,RNMT,RCC1,TAF9,GTF2H5,UBA52,CHMP4B,CXCR4,CDK7,POLR2J,CHMP2B,SEH1L,CHMP5,TAF5,CHMP6,TAF4B,CHMP4C,TPR,NUP35,NUP205,POM121C,XRCC5,TAF3,VPS37C,MNAT1,POLR2B,TAF1L,LIG1,GTF2F2,NUP54,VTA1,XPO1,GTF2A1,TAF11,VPS37A,GTF2E2,LIG4,CTDP1,SUPT5H,NUP37,GTF2H4,NDC1,NUP93,UBB,NELFCD,RANGAP1,POLR2D
R-HSA-917977	Transferrin endocytosis and recycling	0.701999995077622	-0.353821881968261	30	26	0.00287801638255479	9034	10285	100847046,7018,55240,51606,529,10312,261729,525,535,127124,23545,245972,526,9114,57192,523,533,245973,9550,50617,51382,528,155066,90423,7037,8992	MIR5010,TF,STEAP3,ATP6V1H,ATP6V1E1,TCIRG1,STEAP2,ATP6V1B1,ATP6V0A1,ATP6V1G3,ATP6V0A2,ATP6V0D2,ATP6V1B2,ATP6V0D1,MCOLN1,ATP6V1A,ATP6V0B,ATP6V1C2,ATP6V1G1,ATP6V0A4,ATP6V1D,ATP6V1C1,ATP6V0E2,ATP6V1E2,TFRC,ATP6V0E1
R-HSA-420029	Tight junction interactions	0.701999995077622	-0.353821881968261	30	26	0.00287801638255479	9034	10285	26285,137075,7122,84612,51208,9073,5010,10686,24146,9076,50848,9080,1365,84552,9069,10207,23562,1364,1366,56288,64398,149461,53842,49861,5584,9071	CLDN17,CLDN23,CLDN5,PARD6B,CLDN18,CLDN8,CLDN11,CLDN16,CLDN15,CLDN1,F11R,CLDN9,CLDN3,PARD6G,CLDN12,PATJ,CLDN14,CLDN4,CLDN7,PARD3,PALS1,CLDN19,CLDN22,CLDN20,PRKCI,CLDN10
R-HSA-5683826	Surfactant metabolism	0.701999995077622	-0.353821881968261	30	26	0.00287801638255479	9034	10285	643847,51201,21,1512,29080,150,6569,643834,729238,136,1755,6439,135,5222,221395,253970,5029,10568,653509,6441,152,29995,51816,1439,7270,10970	PGA4,ZDHHC2,ABCA3,CTSH,CCDC59,ADRA2A,SLC34A1,PGA3,SFTPA2,ADORA2B,DMBT1,SFTPB,ADORA2A,PGA5,ADGRF5,SFTA3,P2RY2,SLC34A2,SFTPA1,SFTPD,ADRA2C,LMCD1,ADA2,CSF2RB,TTF1,CKAP4
R-HSA-381042	PERK regulates gene expression	0.701999995077622	-0.353821881968261	30	26	0.00287801638255479	9034	10285	3484,1965,9709,5393,56915,51010,22926,5073,6347,4802,4800,167227,9451,11340,468,440,22894,4801,100500888,8570,23404,3309,3576,467,23016,118460	IGFBP1,EIF2S1,HERPUD1,EXOSC9,EXOSC5,EXOSC3,ATF6,PARN,CCL2,NFYC,NFYA,DCP2,EIF2AK3,EXOSC8,ATF4,ASNS,DIS3,NFYB,MIR3940,KHSRP,EXOSC2,HSPA5,CXCL8,ATF3,EXOSC7,EXOSC6
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	0.701999995077622	-0.353821881968261	30	26	0.00287801638255479	9034	10285	1272,83737,83464,23220,51107,6233,1840,54492,182,54567,6868,92737,409,113878,7311,8788,3714,23385,8650,102,9148,7314,5664,142678,408,7316	CNTN1,ITCH,APH1B,DTX4,APH1A,RPS27A,DTX1,NEURL1B,JAG1,DLL4,ADAM17,DNER,ARRB2,DTX2,UBA52,DLK1,JAG2,NCSTN,NUMB,ADAM10,NEURL1,UBB,PSEN2,MIB2,ARRB1,UBC
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	0.701999995077622	-0.353821881968261	30	26	0.00287801638255479	9034	10285	54926,65264,7311,7322,7320,55284,7314,92912,7316,7332,10477,7324,11065,7347,7328,3093,29089,7874,997,7326,90268,7321,6233,8078,7327,55236	UBE2R2,UBE2Z,UBA52,UBE2D2,UBE2B,UBE2W,UBB,UBE2Q2,UBC,UBE2L3,UBE2E3,UBE2E1,UBE2C,UCHL3,UBE2H,UBE2K,UBE2T,USP7,CDC34,UBE2G1,OTULIN,UBE2D1,RPS27A,USP5,UBE2G2,UBA6
R-HSA-193704	p75 NTR receptor-mediated signalling	0.711783775036228	-0.33998110043919	97	84	0.00929820677440779	9034	10285	50650,3065,23263,6655,9639,84894,4099,100271715,29,10018,5924,26084,3551,4974,4790,5879,26230,3066,5584,128272,51107,84033,27237,396,5599,4803,23385,10451,7189,8767,23370,50649,23365,9181,8874,387,7409,7314,22899,23421,9828,4804,5970,121512,1894,9826,83464,6868,4792,26574,836,25791,6233,6453,8841,55160,221472,6654,389337,6610,7204,11108,89846,445328,7531,835,7410,7311,10672,7074,84904,57580,5664,11214,8878,10276,9138,4615,7316,55701,57142,8997,7984,57449	ARHGEF3,HDAC1,MCF2L,SOS2,ARHGEF10,LINGO1,MAG,ARHGEF33,ABR,BCL2L11,RASGRF2,ARHGEF26,IKBKB,OMG,NFKB1,RAC1,TIAM2,HDAC2,PRKCI,ARHGEF19,APH1A,OBSCN,ARHGEF16,ARHGDIA,MAPK8,NGF,NCSTN,VAV3,TRAF6,RIPK2,ARHGEF18,ARHGEF4,ARHGEF12,ARHGEF2,ARHGEF7,RHOA,VAV1,UBB,ARHGEF15,ITGB3BP,ARHGEF17,NGFR,RELA,FGD4,ECT2,ARHGEF11,APH1B,ADAM17,NFKBIA,AATF,CASP3,NGEF,RPS27A,ITSN1,HDAC3,ARHGEF10L,FGD2,SOS1,ARHGEF37,SMPD2,TRIO,PRDM4,FGD3,ARHGEF35,YWHAE,CASP2,VAV2,UBA52,GNA13,TIAM1,ARHGEF39,PREX1,PSEN2,AKAP13,SQSTM1,NET1,ARHGEF1,MYD88,UBC,ARHGEF40,RTN4,KALRN,ARHGEF5,PLEKHG5
R-HSA-69275	G2/M Transition	0.712317953128566	-0.339230903867097	182	158	0.0174894841709099	9034	10285	11064,5720,80028,10213,891,79959,5698,55755,1026,23332,4331,10540,10426,7840,7532,5691,7514,5714,63943,5516,5702,23194,55125,5693,728642,11190,9793,5515,5719,10121,1063,7314,7846,22994,993,54930,9702,4957,3161,5706,5566,93323,5694,995,132660,5711,22897,5707,22981,6233,22822,10142,5718,79866,5577,1639,2033,5700,7311,91750,5699,114791,5048,85378,4605,1022,5684,4926,121441,994,23354,55722,5713,95681,9978,286826,8900,84962,5696,6500,5704,3326,5500,55835,5695,10733,890,8655,55957,5686,4751,8454,100302237,80184,5690,983,11258,4660,5518,3320,5687,5685,7465,84131,10382,1453,6790,5715,5519,79441,5682,5928,5717,10133,22974,9861,115106,10806,80254,9662,8945,1781,54801,5708,27175,23291,5108,54820,4659,1454,9133,5701,902,9491,10197,984,5692,22919,7531,122706,51512,9088,1017,80321,4218,143471,5347,5710,5520,7277,7979,1778,7316,23198,9814,7157,22995,203068	CNTRL,PSME1,FBXL18,PSMD14,CCNB1,CEP76,PSMB9,CDK5RAP2,CDKN1A,CLASP1,MNAT1,DCTN2,TUBGCP3,ALMS1,YWHAG,PSMB3,XPO1,PSMD8,FKBPL,PPP2CB,PSMC3,FBXL7,CEP192,PSMB5,CDK11A,CEP250,CKAP5,PPP2CA,PSMD13,ACTR1A,CENPF,UBB,TUBA1A,CEP131,CDC25A,HAUS4,CEP57,ODF2,HMMR,PSMC6,PRKACA,HAUS8,PSMB6,CDC25C,LIN54,PSMD5,CEP164,PSMD1,NINL,RPS27A,PHLDA1,AKAP9,PSMD12,BORA,PRKAR2B,DCTN1,EP300,PSMC1,UBA52,LIN52,PSMB10,TUBGCP5,PAFAH1B1,TUBGCP6,MYBL2,CDK7,PSMA3,NUMA1,NEDD1,CDC25B,HAUS5,CEP72,PSMD7,CEP41,RBX1,LIN9,CCNA1,AJUBA,PSMB8,SKP1,PSMC4,HSP90AB1,PPP1CB,CENPJ,PSMB7,PLK4,CCNA2,DYNLL1,LIN37,PSMA5,NEK2,CUL1,MIR1281,CEP290,PSMB2,CDK1,DCTN3,PPP1R12B,PPP2R1A,HSP90AA1,PSMA6,PSMA4,WEE1,CEP78,TUBB4A,CSNK1D,AURKA,PSMD9,PPP2R1B,HAUS3,PSMA1,RBBP4,PSMD11,OPTN,TPX2,PSMD6,HAUS1,SDCCAG8,CEP63,CEP135,BTRC,DYNC1I2,HAUS6,PSMD2,TUBG2,FBXW11,PCM1,NDE1,PPP1R12A,CSNK1E,CCNB2,PSMC2,CCNH,PSMF1,PSME3,CDK11B,PSMB4,MAPRE1,YWHAE,PSMB11,GTSE1,PKMYT1,CDK2,CEP70,RAB8A,PSMA8,PLK1,PSMD4,PPP2R2A,TUBA4A,SEM1,DYNC1H1,UBC,PSME4,SFI1,TP53,CEP152,TUBB
R-HSA-917937	Iron uptake and transport	0.716357012883584	-0.33357661494602	44	38	0.00420633163604162	9034	10285	3163,7018,28982,9429,3162,100847046,535,2512,127124,3934,51606,55240,525,1356,261729,10312,529,533,2495,245973,79901,526,23545,245972,4891,523,57192,9114,51310,30061,8992,7037,90423,155066,528,51382,50617,9550	HMOX2,TF,FLVCR1,ABCG2,HMOX1,MIR5010,ATP6V0A1,FTL,ATP6V1G3,LCN2,ATP6V1H,STEAP3,ATP6V1B1,CP,STEAP2,TCIRG1,ATP6V1E1,ATP6V0B,FTH1,ATP6V1C2,CYBRD1,ATP6V1B2,ATP6V0A2,ATP6V0D2,SLC11A2,ATP6V1A,MCOLN1,ATP6V0D1,SLC22A17,SLC40A1,ATP6V0E1,TFRC,ATP6V1E2,ATP6V0E2,ATP6V1C1,ATP6V1D,ATP6V0A4,ATP6V1G1
R-HSA-5668914	Diseases of metabolism	0.716357012883584	-0.33357661494602	44	38	0.00420633163604162	9034	10285	7314,29080,5443,4548,166785,7316,2232,2230,7311,31,729238,5507,2694,4552,112812,6439,2992,4158,8029,6233,81693,3417,653509,5096,6441,253970,2997,7270,2998,1439,5091,4594,51293,56922,1583,27249,7957,5095	UBB,CCDC59,POMC,MTR,MMAA,UBC,FDXR,FDX1,UBA52,ACACA,SFTPA2,PPP1R3C,CBLIF,MTRR,FDX2,SFTPB,GYG1,MC2R,CUBN,RPS27A,AMN,IDH1,SFTPA1,PCCB,SFTPD,SFTA3,GYS1,TTF1,GYS2,CSF2RB,PC,MMUT,CD320,MCCC1,CYP11A1,MMADHC,EPM2A,PCCA
R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	0.722788143363801	-0.324639124156491	81	70	0.00774850564533983	9034	10285	4085,5707,6233,25906,5701,5718,5715,5682,5717,5706,701,11065,7324,5694,9861,5711,8945,5708,5347,143471,5710,26271,7316,51529,7979,5713,23198,996,9491,10197,5700,7311,5692,5699,122706,1017,9184,5684,5695,7321,890,5691,8697,991,51433,5714,5720,8900,10213,5696,891,6500,5698,5704,51343,5687,5685,5719,7314,119504,5686,5702,8454,51434,5690,983,64682,5693,10393,29945	MAD2L1,PSMD1,RPS27A,ANAPC15,PSMC2,PSMD12,PSMD9,PSMA1,PSMD11,PSMC6,BUB1B,UBE2C,UBE2E1,PSMB6,PSMD6,PSMD5,BTRC,PSMD2,PLK1,PSMA8,PSMD4,FBXO5,UBC,ANAPC11,SEM1,PSMD7,PSME4,CDC27,PSMF1,PSME3,PSMC1,UBA52,PSMB4,PSMB10,PSMB11,CDK2,BUB3,PSMA3,PSMB7,UBE2D1,CCNA2,PSMB3,CDC23,CDC20,ANAPC5,PSMD8,PSME1,CCNA1,PSMD14,PSMB8,CCNB1,SKP1,PSMB9,PSMC4,FZR1,PSMA6,PSMA4,PSMD13,UBB,ANAPC16,PSMA5,PSMC3,CUL1,ANAPC7,PSMB2,CDK1,ANAPC1,PSMB5,ANAPC10,ANAPC4
R-HSA-6799198	Complex I biogenesis	0.723669614174676	-0.323420324761351	51	44	0.00487048926278503	9034	10285	28976,4695,4705,4716,29078,4707,91942,4714,4718,126328,51300,4696,80224,4722,4720,4715,4729,4706,51103,4717,4711,4704,51295,4723,79133,4708,55471,4698,374291,51079,55967,4725,4710,4719,4712,137682,4726,4700,4709,4702,4728,100616403,4731,4724	ACAD9,NDUFA2,NDUFA10,NDUFB10,NDUFAF4,NDUFB1,NDUFAF2,NDUFB8,NDUFC2,NDUFA11,TIMMDC1,NDUFA3,NUBPL,NDUFS3,NDUFS2,NDUFB9,NDUFV2,NDUFAB1,NDUFAF1,NDUFC1,NDUFB5,NDUFA9,ECSIT,NDUFV1,NDUFAF5,NDUFB2,NDUFAF7,NDUFA5,NDUFS7,NDUFA13,NDUFA12,NDUFS5,NDUFB4,NDUFS1,NDUFB6,NDUFAF6,NDUFS6,NDUFA6,NDUFB3,NDUFA8,NDUFS8,MIR4691,NDUFV3,NDUFS4
R-HSA-1793185	Chondroitin sulfate/dermatan sulfate metabolism	0.723669614174676	-0.323420324761351	51	44	0.00487048926278503	9034	10285	3339,8372,29940,11285,9469,64131,50515,3425,22856,54480,2262,26229,135152,768213,337876,166012,10082,1463,3373,6382,126792,55501,9672,51363,10090,63827,83539,6385,55454,79586,64132,1464,10675,55790,3074,2817,92126,113189,27087,411,1634,6383,1462,375790	HSPG2,HYAL3,DSE,B4GALT7,CHST3,XYLT1,CHST11,IDUA,CHSY1,CHPF2,GPC5,B3GAT3,B3GAT2,MIR671,CHSY3,CHST13,GPC6,NCAN,HYAL1,SDC1,B3GALT6,CHST12,SDC3,CHST15,UST,BCAN,CHST9,SDC4,CSGALNACT2,CHPF,XYLT2,CSPG4,CSPG5,CSGALNACT1,HEXB,GPC1,DSEL,CHST14,B3GAT1,ARSB,DCN,SDC2,VCAN,AGRN
R-HSA-901032	ER Quality Control Compartment (ERQC)	0.724622085801003	-0.322105020995322	22	19	0.00210316581802081	9034	10285	10299,56886,10206,80267,9695,7311,11236,84447,55757,10956,91445,7316,7844,6400,267,55741,7314,6233,6048	MARCHF6,UGGT1,TRIM13,EDEM3,EDEM1,UBA52,RNF139,SYVN1,UGGT2,OS9,RNF185,UBC,RNF103,SEL1L,AMFR,EDEM2,UBB,RPS27A,RNF5
R-HSA-202427	Phosphorylation of CD3 and TCR zeta chains	0.724622085801003	-0.322105020995322	22	19	0.00210316581802081	9034	10285	3119,26191,3127,1445,55824,915,919,917,5795,3118,920,3113,5788,3117,3122,3120,916,3932,3123	HLA-DQB1,PTPN22,HLA-DRB5,CSK,PAG1,CD3D,CD247,CD3G,PTPRJ,HLA-DQA2,CD4,HLA-DPA1,PTPRC,HLA-DQA1,HLA-DRA,HLA-DQB2,CD3E,LCK,HLA-DRB1
R-HSA-198753	ERK/MAPK targets	0.724622085801003	-0.322105020995322	22	19	0.00210316581802081	9034	10285	5600,1432,4208,5595,5519,5516,6196,9252,5518,1849,1846,6195,5515,5528,5594,51231,4205,5598,1848	MAPK11,MAPK14,MEF2C,MAPK3,PPP2R1B,PPP2CB,RPS6KA2,RPS6KA5,PPP2R1A,DUSP7,DUSP4,RPS6KA1,PPP2CA,PPP2R5D,MAPK1,VRK3,MEF2A,MAPK7,DUSP6
R-HSA-71291	Metabolism of amino acids and derivatives	0.726089552952933	-0.320081920589633	361	314	0.0347575824662387	9034	10285	57515,89874,51582,200916,6138,4948,9491,10197,6159,51074,389434,152926,445,9045,3176,6898,84245,6124,256987,162417,5832,8528,56267,84890,6230,6205,5701,5715,5682,7173,383,6206,55748,5162,2628,2653,5685,6166,25873,1428,131669,2593,3242,223,8942,5686,55256,6165,58478,5690,6202,51166,6139,443,1735,6723,10166,27232,10295,2346,15,51520,384,5704,6123,5723,1152,191,51151,23521,586,8050,219595,5053,1160,262,6164,6539,4706,5713,4548,4947,79048,23743,6137,7311,6224,1743,5699,8659,5860,594,7306,5684,9060,6130,9521,6201,1728,121278,6470,275,65263,5706,6122,6189,1734,5711,1621,6194,6125,1615,501,2730,883,144193,4329,5702,51540,593,6161,1733,6188,1468,5831,6157,3735,23498,6538,5714,374569,51121,11224,7252,6223,116832,10213,6204,7299,5698,1638,2639,6144,55526,143471,118672,5710,4967,7979,36,29968,23198,4953,635,57407,7054,85007,5692,7296,6235,339896,6520,122706,9061,10955,83884,435,2806,11185,6207,10003,6133,27165,6129,3712,5717,2954,9861,11112,2805,6154,5708,189,5687,875,4143,58472,6227,3921,4837,2729,6167,440,4552,84706,5917,6128,6143,3081,6175,5695,1737,6160,2744,6232,50506,113451,4507,9255,6176,125061,8424,4141,5696,2731,8140,56922,140801,6136,3620,6210,2936,7263,6135,6152,1158,5700,6231,80150,130013,4946,5707,6534,6233,6169,2746,6821,7166,549,1036,5718,6142,51686,5409,9380,587,6208,6528,5694,619189,54498,6217,6229,51268,4736,387787,51065,2058,1629,64902,11019,138199,5719,6234,5625,26275,6168,6181,5092,7965,6146,157739,27034,6228,51601,6209,5693,23464,169355,3376,6155,10157,123688,259307,51091,60678,6999,2184,53905,3034,51380,1081,5691,29920,6301,548596,9349,5859,38,5720,1610,1644,6156,2752,54363,1373,8564,1738,1491,4942,1159,347735,3067,79814	SERINC1,SLC25A21,AZIN1,RPL22L1,RPL15,OCA2,PSMF1,PSME3,RPL29,APIP,IYD,PPM1K,ASS1,RPL14,HNMT,TAT,MRI1,RPL4,SERINC5,NAGS,ALDH18A1,DDO,KYAT3,ADO,RPS25,RPS11,PSMC2,PSMD9,PSMA1,TPO,ARG1,RPS12,CNDP2,PDHB,GATM,GCSH,PSMA4,RPL36AL,RPL36,CRYM,UROC1,GAMT,HPD,ALDH9A1,KYNU,PSMA5,ADI1,RPL35A,ENOPH1,PSMB2,RPS8,AADAT,RPL17,ASPA,DIO3,SRM,SLC25A15,GNMT,BCKDK,FOLH1,AANAT,LARS1,ARG2,PSMC4,RPL3L,PSPH,CKB,AHCY,SLC45A2,RPL13A,BCAT1,PDHX,FOLH1B,PAH,CKMT2,AMD1,RPL34,SLC6A12,NDUFAB1,PSMD7,MTR,OAZ2,SECISBP2,BHMT2,RPL13,UBA52,RPS20,DLST,PSMB10,ALDH4A1,QDPR,BCKDHB,TYRP1,PSMA3,PAPSS2,RPL7A,EEF1E1,RPS7,NQO1,TPH2,SHMT1,AMT,PYCR3,PSMC6,RPL3,RPS3A,DIO2,PSMD5,DBH,RPS6,RPL5,DARS1,ALDH7A1,GCLM,KYAT1,AMDHD1,ALDH6A1,PSMC3,SCLY,BCKDHA,RPL32,DIO1,RPS3,SLC25A10,PYCR1,RPL27A,KARS1,HAAO,SLC6A11,PSMD8,ASPG,RPL26L1,RPL35,TSHB,RPS19,RPL39L,PSMD14,RPS10,TYR,PSMB9,DCT,GCDH,RPL21,DHTKD1,PSMA8,PSTK,PSMD4,OGDH,SEM1,ACADSB,PSAT1,PSME4,ODC1,BHMT,NMRAL1,TH,PHYKPL,PSMB4,TXNRD1,RPS29,GADL1,SLC3A2,PSMB11,PAPSS1,SERINC3,SLC25A2,ASL,GOT2,INMT,RPS13,NAALAD2,RPL9,GLS2,RPL7,IVD,PSMD11,GSTZ1,PSMD6,HIBADH,GOT1,RPL26,PSMD2,AGXT,PSMA6,CBS,MAT1A,SQOR,RPS21,RPSA,NNMT,GCLC,RPL37,ASNS,MTRR,GPT2,RARS1,RPL6,RPL19,HGD,RPLP0,PSMB7,DLAT,RPL31,GLS,RPS27,DUOX2,AZIN2,MTAP,AIMP1,RPLP1,AFMID,BBOX1,MARS1,PSMB8,GLDC,SLC7A5,MCCC1,RPL10L,RPL12,IDO1,RPS15A,GSR,TST,RPL11,RPL24,CKM,PSMC1,RPS26,ASRGL1,ACMSD,OAZ1,PSMD1,SLC6A7,RPS27A,RPL38,GLUD1,SUOX,TPH1,AUH,CDO1,PSMD12,RPL18A,OAZ3,PNMT,GRHPR,BCAT2,RPS14,SLC5A5,PSMB6,SERINC4,SMOX,RPS16,RPS24,PIPOX,RPL10A,LIPT2,RPS27L,EPRS1,DBT,AGXT2,LIAS,CARNMT1,PSMD13,RPS28,PRODH,HIBCH,RPL37A,RPLP2,PCBD1,AIMP2,RPL22,TDH,ACAD8,RPS23,LIPT1,RPS15,PSMB5,GCAT,IDO2,IARS1,RPL27,AASS,HYKK,IL4I1,SEPSECS,EEFSEC,TDO2,FAH,DUOX1,HAL,CSAD,CGA,PSMB3,PYCR2,SARS1,CKMT1A,RPL23,QARS1,ACAT1,PSME1,DAO,DDC,RPL30,GLUL,HAO1,CPS1,KMO,DLD,CTH,OAT,CKMT1B,SERINC2,HDC,AGMAT
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis	0.726735274419896	-0.319193001984559	29	25	0.00276732344476422	9034	10285	84944,5431,5441,136991,91646,5434,9271,54514,8468,4603,55124,54456,3320,201164,113802,11022,221400,5440,122402,56165,5433,5430,5439,5432,143689	MAEL,POLR2B,POLR2L,ASZ1,TDRD12,POLR2E,PIWIL1,DDX4,FKBP6,MYBL1,PIWIL2,MOV10L1,HSP90AA1,PLD6,HENMT1,TDRKH,TDRD6,POLR2K,TDRD9,TDRD1,POLR2D,POLR2A,POLR2J,POLR2C,PIWIL4
R-HSA-1482839	Acyl chain remodelling of PE	0.726735274419896	-0.319193001984559	29	25	0.00276732344476422	9034	10285	8398,5322,63874,5320,64600,255189,8605,11145,50487,10162,26279,50640,129642,79887,81579,57110,22925,30814,117245,123745,5319,154141,100137049,283748,5321	PLA2G6,PLA2G5,ABHD4,PLA2G2A,PLA2G2F,PLA2G4F,PLA2G4C,PLAAT3,PLA2G3,LPCAT3,PLA2G2D,PNPLA8,MBOAT2,PLBD1,PLA2G12A,PLAAT1,PLA2R1,PLA2G2E,PLAAT5,PLA2G4E,PLA2G1B,MBOAT1,PLA2G4B,PLA2G4D,PLA2G4A
R-HSA-5682910	LGI-ADAM interactions	0.727685985808081	-0.317885662014235	15	13	0.0014390081912774	9034	10285	4185,203190,59283,100126325,53616,10369,8745,9211,55203,10368,1742,112755,27092	ADAM11,LGI3,CACNG8,MIR935,ADAM22,CACNG2,ADAM23,LGI1,LGI2,CACNG3,DLG4,STX1B,CACNG4
R-HSA-69183	Processive synthesis on the lagging strand	0.727685985808081	-0.317885662014235	15	13	0.0014390081912774	9034	10285	3978,6119,5111,2237,5558,10714,6118,5557,23649,6117,57804,5424,1763	LIG1,RPA3,PCNA,FEN1,PRIM2,POLD3,RPA2,PRIM1,POLA2,RPA1,POLD4,POLD1,DNA2
R-HSA-111447	Activation of BAD and translocation to mitochondria	0.727685985808081	-0.317885662014235	15	13	0.0014390081912774	9034	10285	2810,7534,7531,7533,5534,5533,10000,596,208,7532,7529,10971,207	SFN,YWHAZ,YWHAE,YWHAH,PPP3R1,PPP3CC,AKT3,BCL2,AKT2,YWHAG,YWHAB,YWHAQ,AKT1
R-HSA-3371568	Attenuation phase	0.727685985808081	-0.317885662014235	15	13	0.0014390081912774	9034	10285	3326,3320,3337,3306,100302237,3304,2033,10728,3281,3305,1387,2288,3312	HSP90AB1,HSP90AA1,DNAJB1,HSPA2,MIR1281,HSPA1B,EP300,PTGES3,HSBP1,HSPA1L,CREBBP,FKBP4,HSPA8
R-HSA-5654228	Phospholipase C-mediated cascade; FGFR4	0.727685985808081	-0.317885662014235	15	13	0.0014390081912774	9034	10285	8817,8822,9965,8074,2253,2254,2247,5335,26281,2251,2246,2249,2264	FGF18,FGF17,FGF19,FGF23,FGF8,FGF9,FGF2,PLCG1,FGF20,FGF6,FGF1,FGF4,FGFR4
R-HSA-5358508	Mismatch Repair	0.727685985808081	-0.317885662014235	15	13	0.0014390081912774	9034	10285	9156,6117,5395,4436,5424,4292,2956,57804,5111,3978,6119,6118,10714	EXO1,RPA1,PMS2,MSH2,POLD1,MLH1,MSH6,POLD4,PCNA,LIG1,RPA3,RPA2,POLD3
R-HSA-4419969	Depolymerisation of the Nuclear Lamina	0.727685985808081	-0.317885662014235	15	13	0.0014390081912774	9034	10285	4001,5578,255919,7112,5579,23592,23175,891,983,64900,221496,9663,4000	LMNB1,PRKCA,CNEP1R1,TMPO,PRKCB,LEMD3,LPIN1,CCNB1,CDK1,LPIN3,LEMD2,LPIN2,LMNA
R-HSA-421837	Clathrin derived vesicle budding	0.729682675695447	-0.315145530173301	73	63	0.00697365508080584	9034	10285	8546,1785,84062,51429,1522,375,130340,10717,8729,152503,7037,134829,1212,3482,23557,64746,55330,1777,9026,162,6272,10053,351,81567,1176,10618,5878,164,7163,25977,6456,408,1362,23431,11154,2799,8301,6643,2580,388552,6810,6844,9698,2495,7164,2804,1213,3312,157807,9829,8906,8773,1174,8673,2512,26258,1211,4074,9685,8907,27131,5286,9146	AP3B1,DNM2,DTNBP1,SNX9,CTSZ,ARF1,AP1S3,AP4B1,GBF1,SH3D19,TFRC,CLVS2,CLTB,IGF2R,SNAPIN,ACBD3,BLOC1S4,DNASE2,HIP1R,AP1B1,SORT1,AP1M2,APP,TXNDC5,AP3S1,TGOLN2,RAB5C,AP1G1,TPD52,NECAP1,SH3GL2,ARRB1,CPD,AP4E1,AP4S1,GNS,PICALM,SNX2,GAK,BLOC1S3,STX4,VAMP2,PUM1,FTH1,TPD52L1,GOLGB1,CLTC,HSPA8,CLVS1,DNAJC6,AP1G2,SNAP23,AP1S1,VAMP8,FTL,BLOC1S6,CLTA,M6PR,CLINT1,AP1M1,SNX5,PIK3C2A,HGS
R-HSA-199992	trans-Golgi Network Vesicle Budding	0.729682675695447	-0.315145530173301	73	63	0.00697365508080584	9034	10285	55330,1212,3482,23557,64746,134829,10717,8729,152503,7037,375,130340,84062,51429,1522,8546,1785,1362,25977,6456,408,164,7163,10618,5878,1176,162,10053,351,6272,81567,9026,1777,3312,1213,9698,2495,6810,6844,388552,7164,2804,2580,8301,6643,2799,23431,11154,9146,5286,8907,27131,9685,1211,4074,2512,8673,26258,8773,8906,157807,9829,1174	BLOC1S4,CLTB,IGF2R,SNAPIN,ACBD3,CLVS2,AP4B1,GBF1,SH3D19,TFRC,ARF1,AP1S3,DTNBP1,SNX9,CTSZ,AP3B1,DNM2,CPD,NECAP1,SH3GL2,ARRB1,AP1G1,TPD52,TGOLN2,RAB5C,AP3S1,AP1B1,AP1M2,APP,SORT1,TXNDC5,HIP1R,DNASE2,HSPA8,CLTC,PUM1,FTH1,STX4,VAMP2,BLOC1S3,TPD52L1,GOLGB1,GAK,PICALM,SNX2,GNS,AP4E1,AP4S1,HGS,PIK3C2A,AP1M1,SNX5,CLINT1,CLTA,M6PR,FTL,VAMP8,BLOC1S6,SNAP23,AP1G2,CLVS1,DNAJC6,AP1S1
R-HSA-5389840	Mitochondrial translation elongation	0.730654125362063	-0.313815083923905	88	76	0.00841266327208324	9034	10285	92259,51253,29093,9801,23107,10102,10240,57129,85476,29088,219927,51263,54460,3396,51023,84311,118487,10884,10573,55173,124995,56945,64978,65003,63875,51264,122704,64965,51021,64968,28998,64960,54148,64976,51642,79590,6183,90480,60488,51318,64432,65008,64969,54998,28957,28977,78988,64928,51373,64963,26589,740,128308,64979,54534,64983,55037,51649,64981,51073,51258,54948,7818,55168,65080,100616256,51650,84545,55052,6182,11222,116540,64951,116541,9553,63931	KGD4,MRPL37,MRPL22,MRPL19,MRPS27,TSFM,MRPS31,MRPL47,GFM1,MRPL15,MRPL21,MRPL30,MRPS21,MRPL58,MRPS18C,MRPL45,CHCHD1,MRPS30,MRPL28,MRPS10,MRPL10,MRPS22,MRPL38,MRPL11,MRPL17,MRPL27,MRPL52,MRPS9,MRPS16,MRPS6,MRPL13,MRPS15,MRPL39,MRPL40,MRPL48,MRPL24,MRPS12,GADD45GIP1,MRPS35,MRPL35,MRPS25,MRPL1,MRPS5,AURKAIP1,MRPS28,MRPL42,MRPL57,MRPL14,MRPS17,MRPS11,MRPL46,MRPL49,MRPL55,MRPL36,MRPL50,MRPL32,PTCD3,MRPS23,MRPL34,MRPL4,MRPL51,MRPL16,DAP3,MRPS18A,MRPL44,MIR4721,MRPS33,MRPL43,MRPL20,MRPL12,MRPL3,MRPL53,MRPS24,MRPL54,MRPL33,MRPS14
R-HSA-2559580	Oxidative Stress Induced Senescence	0.731677480663357	-0.312415462300279	126	109	0.012065530219172	9034	10285	723790,5602,6416,8364,1912,7314,8352,8335,1032,1432,6015,22955,4193,1871,3021,2353,55766,1019,7027,8535,50488,3012,5600,648,192670,7311,5595,4217,8346,3017,4194,3015,8368,4343,8350,94239,8347,8345,1030,8361,5606,3725,8357,2146,8970,8355,9448,23512,8340,8363,6233,100500853,1869,57690,5609,9261,23043,8344,7867,23135,8726,1870,3020,57332,8359,5594,8362,128312,8349,27327,26523,1021,3456,5599,23112,8354,23466,8366,121504,8348,80012,7029,6045,8334,1029,126961,3018,8365,8367,7295,8341,8370,7157,8353,7316,192669,8360,1031,5928,8339,8343,5608,1911,3013,84733,8358,653604,8968,5601	H2AC19,MAPK10,MAP2K4,H4C3,PHC2,UBB,H3C3,H2AC4,CDKN2D,MAPK14,RING1,SCMH1,MDM2,E2F3,H3-3B,FOS,H2AJ,CDK4,TFDP1,CBX4,MINK1,H2AC8,MAPK11,BMI1,AGO4,UBA52,MAPK3,MAP3K5,H2BC10,H2BC5,MDM4,H2AZ1,H4C13,MOV10,H3C1,H2AZ2,H2BC4,H2BC9,CDKN2B,H4C6,MAP2K3,JUN,H3C10,EZH2,H2BC11,H3C8,MAP4K4,SUZ12,H2BC13,H4C11,RPS27A,MIR3605,E2F1,TNRC6C,MAP2K7,MAPKAPK2,TNIK,H2BC6,MAPKAPK3,KDM6B,EED,E2F2,H3-3A,CBX8,H4C1,MAPK1,H4C12,H2BC26,H2BC21,TNRC6A,AGO1,CDK6,IFNB1,MAPK8,TNRC6B,H3C11,CBX6,H4C2,H4C16,H2BC17,PHC3,TFDP2,RNF2,H2AC6,CDKN2A,H3C14,H2BC3,H4C8,H4C5,TXN,H2BC15,H4C14,TP53,H3C6,UBC,AGO3,H4C4,CDKN2C,RBBP4,H2BC8,H2BC7,MAP2K6,PHC1,H2AC7,CBX2,H3C2,H3C13,H3C7,MAPK9
R-HSA-6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	0.7361764744979	-0.306285413861707	43	37	0.00409563869825105	9034	10285	10693,2783,8786,2780,2782,6000,10681,406974,2791,2771,8787,59345,1459,51764,9628,2788,22948,2784,2773,2793,1457,2792,2779,2770,2790,2786,5082,10576,2781,94235,10575,54331,10694,10574,55970,2787,346562	CCT6B,GNB2,RGS11,GNAT2,GNB1,RGS7,GNB5,MIR197,GNG11,GNAI2,RGS9,GNB4,CSNK2A2,GNG13,RGS6,GNG7,CCT5,GNB3,GNAI3,GNGT2,CSNK2A1,GNGT1,GNAT1,GNAI1,GNG10,GNG4,PDCL,CCT2,GNAZ,GNG8,CCT4,GNG2,CCT8,CCT7,GNG12,GNG5,GNAT3
R-HSA-75893	TNF signaling	0.7361764744979	-0.306285413861707	43	37	0.00409563869825105	9034	10285	1540,7185,8567,329,6868,3551,56928,90268,6885,6233,330,8717,7124,1147,23118,7128,8887,55512,841,7316,7375,7132,8439,10399,9530,84888,7314,25999,56957,27005,8772,6610,10454,8737,10616,7311,9099	CYLD,TRAF1,MADD,BIRC2,ADAM17,IKBKB,SPPL2B,OTULIN,MAP3K7,RPS27A,BIRC3,TRADD,TNF,CHUK,TAB2,TNFAIP3,TAX1BP1,SMPD3,CASP8,UBC,USP4,TNFRSF1A,NSMAF,RACK1,BAG4,SPPL2A,UBB,CLIP3,OTUD7B,USP21,FADD,SMPD2,TAB1,RIPK1,RBCK1,UBA52,USP2
R-HSA-72731	Recycling of eIF2:GDP	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	8891,8893,1965,8894,1967,8890,8892	EIF2B3,EIF2B5,EIF2S1,EIF2S2,EIF2B1,EIF2B4,EIF2B2
R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	2324,2321,7422,7423,7424,3791,5228	FLT4,FLT1,VEGFA,VEGFB,VEGFC,KDR,PGF
R-HSA-5603027	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	4791,4793,1147,4792,3551,4790,5970	NFKB2,NFKBIB,CHUK,NFKBIA,IKBKB,NFKB1,RELA
R-HSA-196783	Coenzyme A biosynthesis	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	8034,79717,80025,60490,79646,55229,53354	SLC25A16,PPCS,PANK2,PPCDC,PANK3,PANK4,PANK1
R-HSA-5576890	Phase 3 - rapid repolarisation	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	3784,9992,10008,10142,3757,3753,23704	KCNQ1,KCNE2,KCNE3,AKAP9,KCNH2,KCNE1,KCNE4
R-HSA-1236973	Cross-presentation of particulate exogenous antigens (phagosomes)	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	4689,3693,1535,4688,653361,3685,948	NCF4,ITGB5,CYBA,NCF2,NCF1,ITGAV,CD36
R-HSA-164944	Nef and signal transduction	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	3932,919,5062,5879,2534,1794,9844	LCK,CD247,PAK2,RAC1,FYN,DOCK2,ELMO1
R-HSA-977347	Serine biosynthesis	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	57515,10955,619189,5723,347735,29968,256987	SERINC1,SERINC3,SERINC4,PSPH,SERINC2,PSAT1,SERINC5
R-HSA-5362798	Release of Hh-Np from the secreting cell	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	2262,50846,6868,57758,6469,147111,3549	GPC5,DHH,ADAM17,SCUBE2,SHH,NOTUM,IHH
R-HSA-3656532	TGFBR1 KD Mutants in Cancer	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	9372,2280,4087,7040,7046,7048,4088	ZFYVE9,FKBP1A,SMAD2,TGFB1,TGFBR1,TGFBR2,SMAD3
R-HSA-177128	Conjugation of salicylate with glycine	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	92292,123876,348158,10249,219970,389396,341392	GLYATL1,ACSM2A,ACSM2B,GLYAT,GLYATL2,GLYATL3,ACSM4
R-HSA-5358493	Synthesis of diphthamide-EEF2	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	1802,51611,285381,89978,120526,1938,1801	DPH2,DPH5,DPH3,DPH6,DNAJC24,EEF2,DPH1
R-HSA-389397	Orexin and neuropeptides FF and QRFP bind to their respective receptors	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	3060,3062,84109,64106,10886,347148,3061	HCRT,HCRTR2,QRFPR,NPFFR1,NPFFR2,QRFP,HCRTR1
R-HSA-77111	Synthesis of Ketone Bodies	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	3155,79611,65985,38,622,54511,56898	HMGCL,ACSS3,AACS,ACAT1,BDH1,HMGCLL1,BDH2
R-HSA-194313	VEGF ligand-receptor interactions	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	7423,7424,3791,5228,2324,2321,7422	VEGFB,VEGFC,KDR,PGF,FLT4,FLT1,VEGFA
R-HSA-448424	Interleukin-17 signaling	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	132014,84818,27189,112744,23765,3605,55540	IL17RE,IL17RC,IL17C,IL17F,IL17RA,IL17A,IL17RB
R-HSA-446388	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	6251,55742,29780,87,7016,5829,3987	RSU1,PARVA,PARVB,ACTN1,TESK1,PXN,LIMS1
R-HSA-3656534	Loss of Function of TGFBR1 in Cancer	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	2280,9372,4087,7040,7046,7048,4088	FKBP1A,ZFYVE9,SMAD2,TGFB1,TGFBR1,TGFBR2,SMAD3
R-HSA-6787450	tRNA modification in the mitochondrion	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	80324,25821,54802,55006,55687,84705,54931	PUS1,MTO1,TRIT1,TRMT61B,TRMU,GTPBP3,TRMT10C
R-HSA-8937144	Aryl hydrocarbon receptor signalling	0.746881926047816	-0.291848170535798	8	7	0.000774850564533983	9034	10285	9915,57491,196,10728,9049,405,3326	ARNT2,AHRR,AHR,PTGES3,AIP,ARNT,HSP90AB1
R-HSA-432722	Golgi Associated Vesicle Biogenesis	0.747616185766668	-0.290865553331899	57	49	0.00542395395173788	9034	10285	6643,8301,23431,3312,1213,2804,7164,6844,9698,388552,2495,2580,9685,1211,26258,8673,2512,1174,9829,5286,27131,8907,7037,152503,10717,130340,375,51429,84062,8546,1785,55330,64746,23557,3482,1176,81567,6272,10053,162,9026,1362,408,25977,6456,7163,164,5878,10618	SNX2,PICALM,AP4E1,HSPA8,CLTC,GOLGB1,TPD52L1,VAMP2,PUM1,BLOC1S3,FTH1,GAK,CLINT1,CLTA,BLOC1S6,VAMP8,FTL,AP1S1,DNAJC6,PIK3C2A,SNX5,AP1M1,TFRC,SH3D19,AP4B1,AP1S3,ARF1,SNX9,DTNBP1,AP3B1,DNM2,BLOC1S4,ACBD3,SNAPIN,IGF2R,AP3S1,TXNDC5,SORT1,AP1M2,AP1B1,HIP1R,CPD,ARRB1,NECAP1,SH3GL2,TPD52,AP1G1,RAB5C,TGOLN2
R-HSA-1266695	Interleukin-7 signaling	0.751007637021853	-0.286339458132753	28	24	0.00265663050697365	9034	10285	126961,8350,8352,5896,8353,6597,3716,5897,3082,3718,54014,5296,3575,8503,8354,8358,653604,8968,6776,8355,5295,8357,3574,6777	H3C14,H3C1,H3C3,RAG1,H3C6,SMARCA4,JAK1,RAG2,HGF,JAK3,BRWD1,PIK3R2,IL7R,PIK3R3,H3C11,H3C2,H3C13,H3C7,STAT5A,H3C8,PIK3R1,H3C10,IL7,STAT5B
R-HSA-5621480	Dectin-2 family	0.751007637021853	-0.286339458132753	28	24	0.00265663050697365	9034	10285	2534,394263,5336,4588,2207,93978,10462,140453,4585,118430,727897,94025,170482,4589,50856,56667,4067,143662,26253,6850,4583,200958,338339,10071	FYN,MUC21,PLCG2,MUC6,FCER1G,CLEC6A,CLEC10A,MUC17,MUC4,MUCL1,MUC5B,MUC16,CLEC4C,MUC7,CLEC4A,MUC13,LYN,MUC15,CLEC4E,SYK,MUC2,MUC20,CLEC4D,MUC12
R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	0.751007637021853	-0.286339458132753	28	24	0.00265663050697365	9034	10285	253017,2180,11000,79071,83401,51144,51703,79993,9200,51495,6785,54898,23205,197322,60481,201562,81616,64834,23305,9524,2181,401494,5538,3293	TECRL,ACSL1,SLC27A3,ELOVL6,ELOVL3,HSD17B12,ACSL5,ELOVL7,HACD1,HACD3,ELOVL4,ELOVL2,ACSBG1,ACSF3,ELOVL5,HACD2,ACSBG2,ELOVL1,ACSL6,TECR,ACSL3,HACD4,PPT1,HSD17B3
R-HSA-1483191	Synthesis of PC	0.751007637021853	-0.286339458132753	28	24	0.00265663050697365	9034	10285	43,10809,56910,64900,23446,1459,162466,126969,58488,1457,79888,204962,10400,1103,9663,10390,56994,5130,57153,590,23175,1119,84879,80736	ACHE,STARD10,STARD7,LPIN3,SLC44A1,CSNK2A2,PHOSPHO1,SLC44A3,PCTP,CSNK2A1,LPCAT1,SLC44A5,PEMT,CHAT,LPIN2,CEPT1,CHPT1,PCYT1A,SLC44A2,BCHE,LPIN1,CHKA,MFSD2A,SLC44A4
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	0.751007637021853	-0.286339458132753	28	24	0.00265663050697365	9034	10285	27183,128866,7311,8027,137492,91782,7251,92421,7316,9146,7314,51510,79643,11267,10254,25978,51028,79720,55048,9525,51534,84313,51652,6233	VPS4A,CHMP4B,UBA52,STAM,VPS37A,CHMP7,TSG101,CHMP4C,UBC,HGS,UBB,CHMP5,CHMP6,SNF8,STAM2,CHMP2B,VPS36,VPS37B,VPS37C,VPS4B,VTA1,VPS25,CHMP3,RPS27A
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	0.751146914402804	-0.286154021313062	79	68	0.00752711976975869	9034	10285	57461,51138,2073,3978,9318,10714,2067,3980,8178,91603,2068,5984,4331,5431,5424,57654,2873,7314,6917,5430,6119,2968,10920,5433,51426,100302237,2071,8533,64708,2965,1642,2967,5982,57804,7507,5111,6233,5981,5427,902,10987,2072,5434,6118,5985,1161,7874,7515,5441,6117,9716,3150,56655,50813,10450,8451,5439,2074,5432,9978,5440,7316,7311,5983,2033,404672,54107,1022	ISY1,COPS4,ERCC5,LIG1,COPS2,POLD3,ERCC1,LIG3,ELL,ZNF830,ERCC2,RFC4,MNAT1,POLR2B,POLD1,UVSSA,GPS1,UBB,TCEA1,POLR2A,RPA3,GTF2H4,COPS8,POLR2D,POLK,MIR1281,ERCC3,COPS3,COPS7B,GTF2H1,DDB1,GTF2H3,RFC2,POLD4,XPA,PCNA,RPS27A,RFC1,POLE2,CCNH,COPS5,ERCC4,POLR2E,RPA2,RFC5,ERCC8,USP7,XRCC1,POLR2L,RPA1,AQR,HMGN1,POLE4,COPS7A,PPIE,CUL4A,POLR2J,ERCC6,POLR2C,RBX1,POLR2K,UBC,UBA52,RFC3,EP300,GTF2H5,POLE3,CDK7
R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence	0.751146914402804	-0.286154021313062	79	68	0.00752711976975869	9034	10285	26277,8364,723790,472,8344,8290,9134,4001,57634,8359,7014,8335,4683,8349,1026,3159,3009,8362,128312,8900,25913,1027,3012,890,25842,55766,1017,8346,8334,3017,3006,3015,8368,3008,8366,121504,8348,10524,898,8347,7157,8345,3007,8361,3005,3018,8365,8367,8341,8370,94239,23523,8340,10111,8363,8091,4361,65057,7290,3024,8360,8339,8970,8343,5925,3013,29855,7013	TINF2,H4C3,H2AC19,ATM,H2BC6,H3-4,CCNE2,LMNB1,EP400,H4C1,TERF2,H2AC4,NBN,H2BC21,CDKN1A,HMGA1,H1-5,H4C12,H2BC26,CCNA1,POT1,CDKN1B,H2AC8,CCNA2,ASF1A,H2AJ,CDK2,H2BC10,H2AC6,H2BC5,H1-2,H2AZ1,H4C13,H1-4,H4C2,H4C16,H2BC17,KAT5,CCNE1,H2BC4,TP53,H2BC9,H1-3,H4C6,H1-0,H2BC3,H4C8,H4C5,H2BC15,H4C14,H2AZ2,CABIN1,H2BC13,RAD50,H4C11,HMGA2,MRE11,ACD,HIRA,H1-1,H4C4,H2BC8,H2BC11,H2BC7,RB1,H2AC7,UBN1,TERF1
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	0.752476532463135	-0.284385468940904	35	30	0.00332078813371707	9034	10285	2244,7529,6714,3265,2266,5604,7414,54518,283455,5605,3690,673,8826,409,2335,2243,5908,3845,5595,5906,4893,7450,5894,10256,5594,4140,3674,5037,408,1445	FGB,YWHAB,SRC,HRAS,FGG,MAP2K1,VCL,APBB1IP,KSR2,MAP2K2,ITGB3,BRAF,IQGAP1,ARRB2,FN1,FGA,RAP1B,KRAS,MAPK3,RAP1A,NRAS,VWF,RAF1,CNKSR1,MAPK1,MARK3,ITGA2B,PEBP1,ARRB1,CSK
R-HSA-5693537	Resolution of D-Loop Structures	0.752476532463135	-0.284385468940904	35	30	0.00332078813371707	9034	10285	23514,4361,10111,79728,83990,672,9156,580,7517,10635,5892,5890,197342,641,7516,5888,1763,7156,348654,10524,146956,675,116028,472,80010,5889,51750,84464,4683,7486	SPIDR,MRE11,RAD50,PALB2,BRIP1,BRCA1,EXO1,BARD1,XRCC3,RAD51AP1,RAD51D,RAD51B,EME2,BLM,XRCC2,RAD51,DNA2,TOP3A,GEN1,KAT5,EME1,BRCA2,RMI2,ATM,RMI1,RAD51C,RTEL1,SLX4,NBN,WRN
R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	0.752841244675549	-0.283900903854264	21	18	0.00199247288023024	9034	10285	1387,23368,27113,7157,94241,10650,147923,27166,581,84883,55240,7159,5366,8626,472,665,7161,63970	CREBBP,PPP1R13B,BBC3,TP53,TP53INP1,PRELID3A,ZNF420,PRELID1,BAX,AIFM2,STEAP3,TP53BP2,PMAIP1,TP63,ATM,BNIP3L,TP73,TP53AIP1
R-HSA-69618	Mitotic Spindle Checkpoint	0.752841244675549	-0.283900903854264	21	18	0.00199247288023024	9034	10285	9184,29945,10393,64682,51434,11065,701,7324,119504,51433,996,8697,51529,991,7321,25906,8379,4085	BUB3,ANAPC4,ANAPC10,ANAPC1,ANAPC7,UBE2C,BUB1B,UBE2E1,ANAPC16,ANAPC5,CDC27,CDC23,ANAPC11,CDC20,UBE2D1,ANAPC15,MAD1L1,MAD2L1
R-HSA-445144	Signal transduction by L1	0.752841244675549	-0.283900903854264	21	18	0.00199247288023024	9034	10285	3685,5595,2260,7410,1457,5604,8829,4684,3680,3690,1459,5605,5058,1956,3674,5594,5879,3688	ITGAV,MAPK3,FGFR1,VAV2,CSNK2A1,MAP2K1,NRP1,NCAM1,ITGA9,ITGB3,CSNK2A2,MAP2K2,PAK1,EGFR,ITGA2B,MAPK1,RAC1,ITGB1
R-HSA-5651801	PCNA-Dependent Long Patch Base Excision Repair	0.752841244675549	-0.283900903854264	21	18	0.00199247288023024	9034	10285	5424,54107,5423,57804,56655,5982,5983,5984,6117,10714,6118,5985,5981,5111,2237,3978,5427,6119	POLD1,POLE3,POLB,POLD4,POLE4,RFC2,RFC3,RFC4,RPA1,POLD3,RPA2,RFC5,RFC1,PCNA,FEN1,LIG1,POLE2,RPA3
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	0.752841244675549	-0.283900903854264	21	18	0.00199247288023024	9034	10285	3714,4853,23385,83464,7311,1272,4192,142678,7316,5664,54567,182,6233,7314,9148,51107,102,54492	JAG2,NOTCH2,NCSTN,APH1B,UBA52,CNTN1,MDK,MIB2,UBC,PSEN2,DLL4,JAG1,RPS27A,UBB,NEURL1,APH1A,ADAM10,NEURL1B
R-HSA-1181150	Signaling by NODAL	0.752841244675549	-0.283900903854264	21	18	0.00199247288023024	9034	10285	10637,91,55997,4088,93,10589,9350,92,4089,6997,5046,130399,2309,199699,7044,4838,4087,5045	LEFTY1,ACVR1B,CFC1,SMAD3,ACVR2B,DRAP1,CER1,ACVR2A,SMAD4,CRIPTO,PCSK6,ACVR1C,FOXO3,DAND5,LEFTY2,NODAL,SMAD2,FURIN
R-HSA-68874	M/G1 Transition	0.757466191006756	-0.27777637492898	86	74	0.0081912773965021	9034	10285	10926,1870,5693,5690,5686,5702,4171,5000,4175,7314,6119,81620,5687,4999,5719,5685,23595,8318,5704,4173,990,5698,5001,5696,10213,5720,5714,5691,84515,5695,1871,8317,122706,54107,5684,1017,4174,7311,5699,5692,10197,5557,5700,9491,23198,5713,5558,7316,7979,55388,23594,5710,143471,5711,5708,9861,56655,5694,4172,5682,5715,6117,5706,23649,5717,1869,5701,6118,51053,5718,4998,6233,5427,5707	DBF4,E2F2,PSMB5,PSMB2,PSMA5,PSMC3,MCM2,ORC4,MCM6,UBB,RPA3,CDT1,PSMA6,ORC2,PSMD13,PSMA4,ORC3,CDC45,PSMC4,MCM4,CDC6,PSMB9,ORC5,PSMB8,PSMD14,PSME1,PSMD8,PSMB3,MCM8,PSMB7,E2F3,CDC7,PSMB11,POLE3,PSMA3,CDK2,MCM5,UBA52,PSMB10,PSMB4,PSME3,PRIM1,PSMC1,PSMF1,PSME4,PSMD7,PRIM2,UBC,SEM1,MCM10,ORC6,PSMD4,PSMA8,PSMD5,PSMD2,PSMD6,POLE4,PSMB6,MCM3,PSMA1,PSMD9,RPA1,PSMC6,POLA2,PSMD11,E2F1,PSMC2,RPA2,GMNN,PSMD12,ORC1,RPS27A,POLE2,PSMD1
R-HSA-69002	DNA Replication Pre-Initiation	0.757466191006756	-0.27777637492898	86	74	0.0081912773965021	9034	10285	4171,5000,5687,81620,6119,5685,4999,23595,5719,4175,7314,1870,5693,10926,5686,5702,5690,5691,84515,5714,8317,5695,1871,4173,990,5698,8318,5704,5720,5001,5696,10213,7316,7979,55388,5713,23198,5558,5710,143471,23594,4174,122706,5684,54107,1017,5557,10197,5700,9491,7311,5699,5692,1869,6118,5701,51053,4998,5718,5427,5707,6233,56655,9861,5694,5711,5708,5682,5715,6117,5706,5717,23649,4172	MCM2,ORC4,PSMA6,CDT1,RPA3,PSMA4,ORC2,ORC3,PSMD13,MCM6,UBB,E2F2,PSMB5,DBF4,PSMA5,PSMC3,PSMB2,PSMB3,MCM8,PSMD8,CDC7,PSMB7,E2F3,MCM4,CDC6,PSMB9,CDC45,PSMC4,PSME1,ORC5,PSMB8,PSMD14,UBC,SEM1,MCM10,PSMD7,PSME4,PRIM2,PSMD4,PSMA8,ORC6,MCM5,PSMB11,PSMA3,POLE3,CDK2,PRIM1,PSME3,PSMC1,PSMF1,UBA52,PSMB10,PSMB4,E2F1,RPA2,PSMC2,GMNN,ORC1,PSMD12,POLE2,PSMD1,RPS27A,POLE4,PSMD6,PSMB6,PSMD5,PSMD2,PSMA1,PSMD9,RPA1,PSMC6,PSMD11,POLA2,MCM3
R-HSA-6811440	Retrograde transport at the Trans-Golgi-Network	0.759570785381967	-0.2750017613129	49	42	0.0046491033872039	9034	10285	122830,23647,51542,84342,2800,738,57511,2803,22796,10618,60560,10466,9712,10244,83548,9648,51560,55275,4074,84316,9341,79571,25839,400,339122,5870,22836,7110,10228,8675,8677,3482,90196,63908,57589,10226,91949,60592,8674,9382,8774,4905	NAA30,ARFIP2,VPS54,COG8,GOLGA1,VPS51,COG6,GOLGA4,COG2,TGOLN2,NAA35,COG5,USP6NL,RABEPK,COG3,GCC2,RAB6B,VPS53,M6PR,NAA38,VAMP3,GCC1,COG4,ARL1,RAB43,RAB6A,RHOBTB3,TMF1,STX6,STX16,STX10,IGF2R,SYS1,NAPB,RIC1,PLIN3,COG7,SCOC,VAMP4,COG1,NAPG,NSF
R-HSA-209560	NF-kB is activated and signals survival	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	4790,8878,3551,4792,7316,6233,7314,4803,5970,4804,7189,7311	NFKB1,SQSTM1,IKBKB,NFKBIA,UBC,RPS27A,UBB,NGF,RELA,NGFR,TRAF6,UBA52
R-HSA-204174	Regulation of pyruvate dehydrogenase (PDH) complex	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	55066,5163,5164,8050,1737,5467,1738,6256,5166,5162,57546,54704	PDPR,PDK1,PDK2,PDHX,DLAT,PPARD,DLD,RXRA,PDK4,PDHB,PDP2,PDP1
R-HSA-174411	Polymerase switching on the C-strand of the telomere	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	57804,5982,5424,5557,23649,5983,5984,5985,10714,5558,5981,5111	POLD4,RFC2,POLD1,PRIM1,POLA2,RFC3,RFC4,RFC5,POLD3,PRIM2,RFC1,PCNA
R-HSA-209543	p75NTR recruits signalling complexes	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	6233,7314,5584,4615,7316,3551,8878,7311,7189,8767,4804,4803	RPS27A,UBB,PRKCI,MYD88,UBC,IKBKB,SQSTM1,UBA52,TRAF6,RIPK2,NGFR,NGF
R-HSA-190322	FGFR4 ligand binding and activation	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	2264,2249,2246,2247,2254,2251,2253,8074,26281,9965,8822,8817	FGFR4,FGF4,FGF1,FGF2,FGF9,FGF6,FGF8,FGF23,FGF20,FGF19,FGF17,FGF18
R-HSA-69166	Removal of the Flap Intermediate	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	57804,5424,1763,23649,5557,6117,5558,10714,6118,6119,2237,5111	POLD4,POLD1,DNA2,POLA2,PRIM1,RPA1,PRIM2,POLD3,RPA2,RPA3,FEN1,PCNA
R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	604,7161,332,10397,9540,64065,7159,5876,7157,23368,79370,8626	BCL6,TP73,BIRC5,NDRG1,TP53I3,PERP,TP53BP2,RABGGTB,TP53,PPP1R13B,BCL2L14,TP63
R-HSA-69091	Polymerase switching	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	5981,5111,10714,5558,5985,5983,5984,23649,5557,5424,57804,5982	RFC1,PCNA,POLD3,PRIM2,RFC5,RFC3,RFC4,POLA2,PRIM1,POLD1,POLD4,RFC2
R-HSA-69109	Leading Strand Synthesis	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	23649,5557,5984,5983,5982,57804,5424,5111,5981,5985,5558,10714	POLA2,PRIM1,RFC4,RFC3,RFC2,POLD4,POLD1,PCNA,RFC1,RFC5,PRIM2,POLD3
R-HSA-5675482	Regulation of necroptotic cell death	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	329,355,8795,8743,8797,8837,330,8737,356,8717,8772,841	BIRC2,FAS,TNFRSF10B,TNFSF10,TNFRSF10A,CFLAR,BIRC3,RIPK1,FASLG,TRADD,FADD,CASP8
R-HSA-5358606	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	0.76224245612778	-0.271490590010527	14	12	0.00132831525348683	9034	10285	9156,6117,4292,5424,5395,4436,57804,5111,3978,6119,6118,10714	EXO1,RPA1,MLH1,POLD1,PMS2,MSH2,POLD4,PCNA,LIG1,RPA3,RPA2,POLD3
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	0.764022946272089	-0.269157455879089	56	48	0.00531326101394731	9034	10285	5704,5698,6500,5696,10213,80028,5720,5714,5691,5695,5693,5690,23194,8454,5702,5686,6790,7314,5685,5719,5687,5708,5711,9861,5694,5706,5717,5682,5715,5718,5701,6233,5707,5684,122706,5699,5692,7311,5700,10197,9491,9978,23198,5713,7316,7979,5710,143471	PSMC4,PSMB9,SKP1,PSMB8,PSMD14,FBXL18,PSME1,PSMD8,PSMB3,PSMB7,PSMB5,PSMB2,FBXL7,CUL1,PSMC3,PSMA5,AURKA,UBB,PSMA4,PSMD13,PSMA6,PSMD2,PSMD5,PSMD6,PSMB6,PSMC6,PSMD11,PSMA1,PSMD9,PSMD12,PSMC2,RPS27A,PSMD1,PSMA3,PSMB11,PSMB10,PSMB4,UBA52,PSMC1,PSME3,PSMF1,RBX1,PSME4,PSMD7,UBC,SEM1,PSMD4,PSMA8
R-HSA-4641257	Degradation of AXIN	0.764022946272089	-0.269157455879089	56	48	0.00531326101394731	9034	10285	5694,9861,5708,5711,5717,5706,5715,5682,5718,5701,5707,6233,5684,122706,9491,10197,5700,8312,5692,5699,7311,7979,7316,23198,5713,143471,5710,5698,5704,5720,81847,10213,5696,8658,5691,64750,5714,80351,5695,5693,8313,5702,5686,5690,5719,5685,5687,7314	PSMB6,PSMD6,PSMD2,PSMD5,PSMD11,PSMC6,PSMD9,PSMA1,PSMD12,PSMC2,PSMD1,RPS27A,PSMA3,PSMB11,PSMF1,PSME3,PSMC1,AXIN1,PSMB4,PSMB10,UBA52,SEM1,UBC,PSME4,PSMD7,PSMA8,PSMD4,PSMB9,PSMC4,PSME1,RNF146,PSMD14,PSMB8,TNKS,PSMB3,SMURF2,PSMD8,TNKS2,PSMB7,PSMB5,AXIN2,PSMC3,PSMA5,PSMB2,PSMD13,PSMA4,PSMA6,UBB
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	0.764022946272089	-0.269157455879089	56	48	0.00531326101394731	9034	10285	6233,5707,5701,5718,5682,5715,5706,5717,8945,5711,5708,9861,5694,5710,143471,5713,23198,7979,7316,26271,7311,5699,5692,5700,10197,9491,122706,5684,5695,5714,5691,991,5696,10213,5720,5704,6500,5698,7314,5687,51343,5685,5719,5690,5686,8454,5702,5693	RPS27A,PSMD1,PSMC2,PSMD12,PSMA1,PSMD9,PSMC6,PSMD11,BTRC,PSMD5,PSMD2,PSMD6,PSMB6,PSMD4,PSMA8,PSMD7,PSME4,SEM1,UBC,FBXO5,UBA52,PSMB10,PSMB4,PSMC1,PSME3,PSMF1,PSMB11,PSMA3,PSMB7,PSMD8,PSMB3,CDC20,PSMB8,PSMD14,PSME1,PSMC4,SKP1,PSMB9,UBB,PSMA6,FZR1,PSMA4,PSMD13,PSMB2,PSMA5,CUL1,PSMC3,PSMB5
R-HSA-69541	Stabilization of p53	0.764022946272089	-0.269157455879089	56	48	0.00531326101394731	9034	10285	5682,5715,5706,5717,5711,5708,9861,5694,6233,5707,5701,5718,7311,5699,5692,5700,10197,9491,122706,5684,4194,5710,143471,7157,5713,23198,7316,7979,5696,10213,5720,5704,4193,64326,5698,5695,5714,11200,5691,5690,472,5686,5702,5693,7314,5687,5685,5719	PSMA1,PSMD9,PSMC6,PSMD11,PSMD5,PSMD2,PSMD6,PSMB6,RPS27A,PSMD1,PSMC2,PSMD12,UBA52,PSMB10,PSMB4,PSMC1,PSME3,PSMF1,PSMB11,PSMA3,MDM4,PSMD4,PSMA8,TP53,PSMD7,PSME4,UBC,SEM1,PSMB8,PSMD14,PSME1,PSMC4,MDM2,COP1,PSMB9,PSMB7,PSMD8,CHEK2,PSMB3,PSMB2,ATM,PSMA5,PSMC3,PSMB5,UBB,PSMA6,PSMA4,PSMD13
R-HSA-1483257	Phospholipid metabolism	0.766214382594648	-0.266293275559677	207	179	0.0198140358645118	9034	10285	8398,64419,9107,55300,54947,10390,55349,375,23396,204962,84803,22925,8898,27124,388121,93492,8904,83394,8871,79837,51552,9896,5321,55224,80736,57664,3635,9362,84649,590,23175,79143,51763,5783,133121,3636,1457,9663,1103,5297,80821,117245,5286,5290,54477,79626,80230,55361,55500,5338,201164,84879,151056,8867,25816,79153,9108,377,56994,23760,30849,10400,635,9110,1459,81544,22874,29958,100137049,84725,10423,1757,8897,5322,122618,5298,3631,8503,56261,5305,80339,23259,81579,55326,5337,57110,3032,59339,154141,5728,23646,57104,255189,200576,55697,5867,57153,26279,50640,9926,79887,5130,9600,27132,51205,126969,43,114882,114971,146850,8394,8760,248,5296,129642,9791,51365,5295,30814,58488,162466,501,123745,1040,54675,23446,56895,283748,5287,22908,22876,5833,63874,5320,5294,1119,8605,5289,57678,23171,8396,8821,59338,11343,5868,79888,8395,284161,57605,8443,10908,3030,5319,56894,253558,56910,8895,51573,64600,11145,114884,137964,50487,10162,23761,5291,65977,114879,23533,126282,64850,5293,150763,9489,5288,81490,64900,2819,10809	PLA2G6,MTMR14,MTMR6,PI4K2B,LPCAT2,CEPT1,CHDH,ARF1,PIP5K1C,SLC44A5,GPAT3,PLA2R1,MTMR2,INPP5J,TNFAIP8L3,TPTE2,CPNE1,PITPNM3,SYNJ2,PIP4K2C,RAB14,FIG4,PLA2G4A,ETNK2,SLC44A4,PLEKHA4,INPP5D,CPNE6,DGAT2,BCHE,LPIN1,MBOAT7,INPP5K,PTPN13,ENPP6,INPPL1,CSNK2A1,LPIN2,CHAT,PI4KA,DDHD1,PLAAT5,PIK3C2A,PIK3CA,PLEKHA5,TNFAIP8L2,RUFY1,PI4K2A,ETNK1,PLD2,PLD6,MFSD2A,PLB1,SYNJ1,TNFAIP8,GDPD3,MTMR7,ARF3,CHPT1,PITPNB,PIK3R4,PEMT,BHMT,MTMR4,CSNK2A2,GDPD5,PLEKHA6,DMGDH,PLA2G4B,PLEKHA8,CDIPT,SARDH,MTMR3,PLA2G5,PLD4,PI4KB,INPP4A,PIK3R3,GPCPD1,PIP4K2A,PNPLA3,DDHD2,PLA2G12A,AGPAT5,PLD1,PLAAT1,HADHB,PLEKHA2,MBOAT1,PTEN,PLD3,PNPLA2,PLA2G4F,PIKFYVE,VAC14,RAB4A,SLC44A2,PLA2G2D,PNPLA8,LPGAT1,PLBD1,PCYT1A,PITPNM1,CPNE7,ACP6,SLC44A3,ACHE,OSBPL8,PTPMT1,PIK3R6,PIP5K1A,CDS2,ALPI,PIK3R2,MBOAT2,PTDSS1,PLA1A,PIK3R1,PLA2G2E,PCTP,PHOSPHO1,ALDH7A1,PLA2G4E,CDS1,CRLS1,SLC44A1,AGPAT4,PLA2G4D,PIK3C2B,SACM1L,INPP5F,PCYT2,ABHD4,PLA2G2A,PIK3CG,CHKA,PLA2G4C,PIK3C3,GPAM,GPD1L,PIP4K2B,INPP4B,PLEKHA1,MGLL,RAB5A,LPCAT1,PIP5K1B,GDPD1,PITPNM2,GNPAT,PNPLA6,HADHA,PLA2G1B,AGPAT3,LCLAT1,STARD7,CPNE3,GDE1,PLA2G2F,PLAAT3,OSBPL10,GPAT4,PLA2G3,LPCAT3,PISD,PIK3CB,PLEKHA3,OSBPL5,PIK3R5,TNFAIP8L1,ETNPPL,PIK3CD,GPAT2,PGS1,PIK3C2G,PTDSS2,LPIN3,GPD1,STARD10
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	0.769456707954203	-0.262070587254401	100	86	0.00951959264998893	9034	10285	261734,8655,55835,22832,10733,11258,983,3320,5518,4751,57545,80184,80776,84902,10382,1453,84131,146057,80254,10806,51134,27077,115106,1781,54801,9662,79441,23322,79867,1454,54903,54820,5108,7531,22919,80321,132320,91147,1778,79600,203068,347240,22995,9814,4218,57787,5347,7277,9657,55755,79959,23332,79598,11064,54806,10540,7532,7840,55125,51259,11190,8766,22994,9702,54930,9793,10121,7846,22897,4957,26123,93323,5566,85302,10142,22981,117177,26005,5048,5577,1639,4867,55722,95681,121441,23354	NPHP4,DYNLL1,CENPJ,CEP162,PLK4,DCTN3,CDK1,HSP90AA1,PPP2R1A,NEK2,CC2D2A,CEP290,B9D2,CEP89,TUBB4A,CSNK1D,CEP78,TTBK2,CEP63,SDCCAG8,CEP83,B9D1,HAUS1,DYNC1I2,HAUS6,CEP135,HAUS3,RPGRIP1L,TCTN2,CSNK1E,MKS1,NDE1,PCM1,YWHAE,MAPRE1,CEP70,SCLT1,TMEM67,DYNC1H1,TCTN1,TUBB,KIF24,CEP152,SFI1,RAB8A,MARK4,PLK1,TUBA4A,IQCB1,CDK5RAP2,CEP76,CLASP1,CEP97,CNTRL,AHI1,DCTN2,YWHAG,ALMS1,CEP192,TMEM216,CEP250,RAB11A,CEP131,CEP57,HAUS4,CKAP5,ACTR1A,TUBA1A,CEP164,ODF2,TCTN3,HAUS8,PRKACA,FBF1,AKAP9,NINL,RAB3IP,C2CD3,PAFAH1B1,PRKAR2B,DCTN1,NPHP1,CEP72,CEP41,NEDD1,HAUS5
R-HSA-3359475	Defective MMAA causes methylmalonic aciduria type cblA	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4594,166785	MMUT,MMAA
R-HSA-211994	Sterols are 12-hydroxylated by CYP8B1	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	5740,1582	PTGIS,CYP8B1
R-HSA-168275	Entry of Influenza Virion into Host Cell via Endocytosis	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	1213,1211	CLTC,CLTA
R-HSA-8942233	Intestinal infectious diseases	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	79849,2984	NHERF4,GUCY2C
R-HSA-451307	Activation of Na-permeable Kainate Receptors	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	2897,2898	GRIK1,GRIK2
R-HSA-5652227	Fructose biosynthesis	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	231,6652	AKR1B1,SORD
R-HSA-8854521	Interaction between PHLDA1 and AURKA	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	22822,6790	PHLDA1,AURKA
R-HSA-428559	Proton-coupled neutral amino acid transporters	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	206358,153201	SLC36A1,SLC36A2
R-HSA-6804754	Regulation of TP53 Expression	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	7157,639	TP53,PRDM1
R-HSA-3642279	TGFBR2 MSI Frameshift Mutants in Cancer	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	7048,7040	TGFBR2,TGFB1
R-HSA-844623	The IPAF inflammasome	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	58484,834	NLRC4,CASP1
R-HSA-3828062	Glycogen storage disease type 0 (muscle GYS1)	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	2992,2997	GYG1,GYS1
R-HSA-165160	PDE3B signalling	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	208,5140	AKT2,PDE3B
R-HSA-168316	Assembly of Viral Components at the Budding Site	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	821,811	CANX,CALR
R-HSA-164939	Nef mediated downregulation of CD28 cell surface expression	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	1173,940	AP2M1,CD28
R-HSA-75896	Plasmalogen biosynthesis	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	8443,8540	GNPAT,AGPS
R-HSA-75064	mRNA Editing: A to I Conversion	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	103,104	ADAR,ADARB1
R-HSA-187042	TRKA activation by NGF	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4914,4803	NTRK1,NGF
R-HSA-198765	Signalling to ERK5	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	5598,5607	MAPK7,MAP2K5
R-HSA-916853	Degradation of GABA	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	7915,18	ALDH5A1,ABAT
R-HSA-163754	Insulin effects increased synthesis of Xylulose-5-Phosphate	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	7086,6888	TKT,TALDO1
R-HSA-203754	NOSIP mediated eNOS trafficking	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4846,51070	NOS3,NOSIP
R-HSA-5687868	Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	729238,6441	SFTPA2,SFTPD
R-HSA-166020	Transfer of LPS from LBP carrier to CD14	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	929,3929	CD14,LBP
R-HSA-70688	Proline catabolism	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	5625,8659	PRODH,ALDH4A1
R-HSA-3359469	Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4552,4548	MTRR,MTR
R-HSA-5619107	Defective TRP may confer susceptibility towards thyroid papillary carcinoma (TPC)	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	2645,2646	GCK,GCKR
R-HSA-190872	Transport of connexons to the plasma membrane	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	2697,2706	GJA1,GJB2
R-HSA-141444	Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4085,8379	MAD2L1,MAD1L1
R-HSA-8849175	Threonine catabolism	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	157739,23464	TDH,GCAT
R-HSA-432030	Transport of glycerol from adipocytes to the liver by Aquaporins	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	364,366	AQP7,AQP9
R-HSA-177162	Conjugation of phenylacetate with glutamine	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	348158,116285	ACSM2B,ACSM1
R-HSA-192905	vRNP Assembly	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	3843,3320	IPO5,HSP90AA1
R-HSA-156582	Acetylation	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	9,10	NAT1,NAT2
R-HSA-1299316	TWIK-releated acid-sensitive K+ channel (TASK)	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	51305,3777	KCNK9,KCNK3
R-HSA-111995	phospho-PLA2 pathway	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	5594,5321	MAPK1,PLA2G4A
R-HSA-168268	Virus Assembly and Release	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	821,811	CANX,CALR
R-HSA-111457	Release of apoptotic factors from the mitochondria	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	56616,54205	DIABLO,CYCS
R-HSA-3814836	Glycogen storage disease type XV (GYG1)	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	2997,2992	GYS1,GYG1
R-HSA-5683177	Defective ABCC8 can cause hypoglycemias and hyperglycemias	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	3767,6833	KCNJ11,ABCC8
R-HSA-71737	Pyrophosphate hydrolysis	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	5464,27068	PPA1,PPA2
R-HSA-5579031	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	5443,4158	POMC,MC2R
R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	89822,83795	KCNK17,KCNK16
R-HSA-168315	Inhibition of Host mRNA Processing and RNA Silencing	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	10898,8106	CPSF4,PABPN1
R-HSA-1483152	Hydrolysis of LPE	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	8605,56261	PLA2G4C,GPCPD1
R-HSA-1614603	Cysteine formation from homocysteine	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	1491,875	CTH,CBS
R-HSA-211728	Regulation of PAK-2p34 activity by PS-GAP/RHG10	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	79658,5062	ARHGAP10,PAK2
R-HSA-77042	Formation of editosomes by ADAR proteins	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	104,103	ADARB1,ADAR
R-HSA-3359478	Defective MUT causes methylmalonic aciduria mut type	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4594,166785	MMUT,MMAA
R-HSA-1483101	Synthesis of PS	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	9791,81490	PTDSS1,PTDSS2
R-HSA-5638302	Signaling by Overexpressed Wild-Type EGFR in Cancer	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	1956,1950	EGFR,EGF
R-HSA-211736	Stimulation of the cell death response by PAK-2p34	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	5062,836	PAK2,CASP3
R-HSA-68881	Mitotic Metaphase/Anaphase Transition	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	26271,5347	FBXO5,PLK1
R-HSA-205017	NFG and proNGF binds to p75NTR	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4804,4803	NGFR,NGF
R-HSA-5602566	TICAM1 deficiency - HSE	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	7098,148022	TLR3,TICAM1
R-HSA-888568	GABA synthesis	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	2572,2571	GAD2,GAD1
R-HSA-351143	Agmatine biosynthesis	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	79814,113451	AGMAT,AZIN2
R-HSA-5638303	Inhibition of Signaling by Overexpressed EGFR	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	1956,1950	EGFR,EGF
R-HSA-5545619	XAV939 inhibits tankyrase, stabilizing AXIN	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	8658,80351	TNKS,TNKS2
R-HSA-75102	C6 deamination of adenosine	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	104,103	ADARB1,ADAR
R-HSA-141424	Amplification of signal from the kinetochores	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4085,8379	MAD2L1,MAD1L1
R-HSA-3359467	Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	0.771517413000089	-0.259396037115948	2	2	0.000221385875581138	9034	10285	4548,4552	MTR,MTRR
R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates	0.773454325850054	-0.256888659387242	34	29	0.0032100951959265	9034	10285	83990,672,9156,580,7517,23514,4361,10111,79728,641,7516,5888,5892,10635,5890,197342,146956,10524,675,116028,472,1763,7156,348654,4683,7486,80010,5889,84464	BRIP1,BRCA1,EXO1,BARD1,XRCC3,SPIDR,MRE11,RAD50,PALB2,BLM,XRCC2,RAD51,RAD51D,RAD51AP1,RAD51B,EME2,EME1,KAT5,BRCA2,RMI2,ATM,DNA2,TOP3A,GEN1,NBN,WRN,RMI1,RAD51C,SLX4
R-HSA-1483166	Synthesis of PA	0.773454325850054	-0.256888659387242	34	29	0.0032100951959265	9034	10285	55326,79888,81579,23259,26279,57678,23171,248,137964,5322,64600,5320,5321,5338,283748,100137049,2819,56895,5319,56894,253558,51205,80821,84803,22925,150763,30814,8443,5337	AGPAT5,LPCAT1,PLA2G12A,DDHD2,PLA2G2D,GPAM,GPD1L,ALPI,GPAT4,PLA2G5,PLA2G2F,PLA2G2A,PLA2G4A,PLD2,PLA2G4D,PLA2G4B,GPD1,AGPAT4,PLA2G1B,AGPAT3,LCLAT1,ACP6,DDHD1,GPAT3,PLA2R1,GPAT2,PLA2G2E,GNPAT,PLD1
R-HSA-77387	Insulin receptor recycling	0.774689323523497	-0.255293202872707	27	23	0.00254593756918309	9034	10285	100847046,127124,535,3643,3630,525,529,10312,51606,245973,533,523,9114,245972,23545,526,8992,155066,528,90423,9550,50617,51382	MIR5010,ATP6V1G3,ATP6V0A1,INSR,INS,ATP6V1B1,ATP6V1E1,TCIRG1,ATP6V1H,ATP6V1C2,ATP6V0B,ATP6V1A,ATP6V0D1,ATP6V0D2,ATP6V0A2,ATP6V1B2,ATP6V0E1,ATP6V0E2,ATP6V1C1,ATP6V1E2,ATP6V1G1,ATP6V0A4,ATP6V1D
R-HSA-901042	Calnexin/calreticulin cycle	0.774689323523497	-0.255293202872707	27	23	0.00254593756918309	9034	10285	23193,55757,10956,91445,6400,267,55741,6233,56886,10206,80267,9695,11236,811,7844,7316,821,7314,5589,6048,10299,7311,84447	GANAB,UGGT2,OS9,RNF185,SEL1L,AMFR,EDEM2,RPS27A,UGGT1,TRIM13,EDEM3,EDEM1,RNF139,CALR,RNF103,UBC,CANX,UBB,PRKCSH,RNF5,MARCHF6,UBA52,SYVN1
R-HSA-380994	ATF4 activates genes	0.774689323523497	-0.255293202872707	27	23	0.00254593756918309	9034	10285	23404,118460,23016,3576,467,4801,100500888,8570,22894,6347,440,468,11340,167227,4802,4800,9709,3484,5073,51010,22926,56915,5393	EXOSC2,EXOSC6,EXOSC7,CXCL8,ATF3,NFYB,MIR3940,KHSRP,DIS3,CCL2,ASNS,ATF4,EXOSC8,DCP2,NFYC,NFYA,HERPUD1,IGFBP1,PARN,EXOSC3,ATF6,EXOSC5,EXOSC9
R-HSA-382556	ABC-family proteins mediated transport	0.775144798834538	-0.254705429874831	107	92	0.0101837502767323	9034	10285	5717,5715,5682,340273,9861,5708,225,11160,5825,3767,7415,10956,5701,9491,10197,10257,89845,5692,64240,10351,79139,91319,122706,8504,143471,5710,21,23456,7979,7316,4363,23198,10057,5696,5704,10349,10613,8714,335,5695,1244,6400,91445,85320,10060,5686,5690,1080,5685,5687,10350,64241,5706,5694,5711,5707,6233,5718,6041,5700,5244,5699,7311,23457,10347,5684,6048,11194,23460,64137,5713,5720,5243,10213,5698,24,10058,26154,5824,5691,5714,5702,6059,5693,9619,23461,5719,7314,23,6833,8894,1965	PSMD11,PSMD9,PSMA1,ABCB5,PSMD6,PSMD2,ABCD2,ERLIN2,ABCD3,KCNJ11,VCP,OS9,PSMC2,PSMF1,PSME3,ABCC4,ABCC10,PSMB4,ABCG5,ABCA8,DERL1,DERL3,PSMB11,PEX3,PSMA8,PSMD4,ABCA3,ABCB10,SEM1,UBC,ABCC1,PSME4,ABCC5,PSMB8,PSMC4,ABCA10,ERLIN1,ABCC3,APOA1,PSMB7,ABCC2,SEL1L,RNF185,ABCC11,ABCC9,PSMA5,PSMB2,CFTR,PSMA4,PSMA6,ABCA9,ABCG8,PSMC6,PSMB6,PSMD5,PSMD1,RPS27A,PSMD12,RNASEL,PSMC1,ABCB4,PSMB10,UBA52,ABCB9,ABCA7,PSMA3,RNF5,ABCB8,ABCA6,ABCG4,PSMD7,PSME1,ABCB1,PSMD14,PSMB9,ABCA4,ABCB6,ABCA12,PEX19,PSMB3,PSMD8,PSMC3,ABCE1,PSMB5,ABCG1,ABCA5,PSMD13,UBB,ABCF1,ABCC8,EIF2S2,EIF2S1
R-HSA-176814	Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	0.778365456869012	-0.250559126190342	77	66	0.00730573389417755	9034	10285	64682,983,5693,10393,29945,5686,4751,5702,51434,5690,119504,5687,5719,5685,7314,891,5698,5704,5720,8900,10213,5696,890,5691,8697,991,5714,9232,51433,5695,7321,122706,9184,5684,9491,5700,10197,7311,5692,5699,7979,51529,7316,23198,5713,996,143471,5347,5710,5694,9861,5711,5708,5715,5682,5717,5706,701,11065,7324,5701,5718,4085,5707,6233,25906	ANAPC1,CDK1,PSMB5,ANAPC10,ANAPC4,PSMA5,NEK2,PSMC3,ANAPC7,PSMB2,ANAPC16,PSMA6,PSMD13,PSMA4,UBB,CCNB1,PSMB9,PSMC4,PSME1,CCNA1,PSMD14,PSMB8,CCNA2,PSMB3,CDC23,CDC20,PSMD8,PTTG1,ANAPC5,PSMB7,UBE2D1,PSMB11,BUB3,PSMA3,PSMF1,PSMC1,PSME3,UBA52,PSMB4,PSMB10,SEM1,ANAPC11,UBC,PSME4,PSMD7,CDC27,PSMA8,PLK1,PSMD4,PSMB6,PSMD6,PSMD5,PSMD2,PSMD9,PSMA1,PSMD11,PSMC6,BUB1B,UBE2C,UBE2E1,PSMC2,PSMD12,MAD2L1,PSMD1,RPS27A,ANAPC15
R-HSA-180585	Vif-mediated degradation of APOBEC3G	0.78002937649834	-0.248423697830342	55	47	0.00520256807615674	9034	10285	122706,5684,7311,5699,5692,10197,5700,9491,23198,5713,9978,6923,7316,7979,60489,8065,5710,143471,5711,5708,9861,6921,5694,5682,5715,5706,5717,5701,5718,6233,5707,5693,5690,5686,5702,7314,5687,5719,5685,5704,5698,5696,10213,5720,5714,5691,5695	PSMB11,PSMA3,UBA52,PSMB10,PSMB4,PSME3,PSMC1,PSMF1,PSME4,PSMD7,RBX1,ELOB,UBC,SEM1,APOBEC3G,CUL5,PSMD4,PSMA8,PSMD5,PSMD2,PSMD6,ELOC,PSMB6,PSMA1,PSMD9,PSMC6,PSMD11,PSMC2,PSMD12,RPS27A,PSMD1,PSMB5,PSMB2,PSMA5,PSMC3,UBB,PSMA6,PSMD13,PSMA4,PSMC4,PSMB9,PSMB8,PSMD14,PSME1,PSMD8,PSMB3,PSMB7
R-HSA-141430	Inactivation of APC/C via direct inhibition of the APC/C complex	0.780374137764746	-0.24798181049945	20	17	0.00188177994243967	9034	10285	991,51529,8697,996,119504,51433,4085,7321,25906,10393,64682,9184,29945,7324,51434,11065,701	CDC20,ANAPC11,CDC23,CDC27,ANAPC16,ANAPC5,MAD2L1,UBE2D1,ANAPC15,ANAPC10,ANAPC1,BUB3,ANAPC4,UBE2E1,ANAPC7,UBE2C,BUB1B
R-HSA-141405	Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	0.780374137764746	-0.24798181049945	20	17	0.00188177994243967	9034	10285	996,119504,51433,51529,8697,991,7321,25906,4085,9184,29945,10393,64682,7324,51434,11065,701	CDC27,ANAPC16,ANAPC5,ANAPC11,CDC23,CDC20,UBE2D1,ANAPC15,MAD2L1,BUB3,ANAPC4,ANAPC10,ANAPC1,UBE2E1,ANAPC7,UBE2C,BUB1B
R-HSA-3000170	Syndecan interactions	0.780374137764746	-0.24798181049945	20	17	0.00188177994243967	9034	10285	5578,3688,7057,3693,9672,3673,2247,3690,6385,7040,3371,6383,3691,3655,6382,87,3685	PRKCA,ITGB1,THBS1,ITGB5,SDC3,ITGA2,FGF2,ITGB3,SDC4,TGFB1,TNC,SDC2,ITGB4,ITGA6,SDC1,ACTN1,ITGAV
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	0.787478523515194	-0.238919180380967	69	59	0.00653088332964357	9034	10285	6827,5434,902,2962,100302242,545,6749,5441,3725,904,7469,8812,5395,4292,6921,51224,162699,5432,5439,905,2176,7157,5440,6923,404672,51755,1643,100126332,1022,2177,7936,2353,2963,5892,9656,8178,6924,2068,672,4331,5431,1386,8621,6917,100506888,2968,5430,5433,51497,6829,472,55215,9150,1111,2071,2965,4436,2967,11198	SUPT4H1,POLR2E,CCNH,GTF2F1,MIR1236,ATR,SSRP1,POLR2L,JUN,CCNT1,NELFA,CCNK,PMS2,MLH1,ELOC,ELOA2,ELOA3P,POLR2C,POLR2J,CCNT2,FANCC,TP53,POLR2K,ELOB,GTF2H5,CDK12,DDB2,MIR943,CDK7,FANCD2,NELFE,FOS,GTF2F2,RAD51D,MDC1,ELL,ELOA,ERCC2,BRCA1,MNAT1,POLR2B,ATF2,CDK13,TCEA1,ELOA3DP,GTF2H4,POLR2A,POLR2D,NELFCD,SUPT5H,ATM,FANCI,CTDP1,CHEK1,ERCC3,GTF2H1,MSH2,GTF2H3,SUPT16H
R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements	0.787944096818085	-0.238328134765097	91	78	0.00863404914766438	9034	10285	9491,10197,5700,5692,5699,5600,7311,8021,5684,3315,122706,143471,5393,5710,54464,56915,5580,5073,7979,7316,7538,23198,5713,5578,5717,5706,5715,5682,7529,118460,5694,9861,5708,5711,5707,3842,1994,6233,5718,100500888,5701,8570,5702,677,5686,11340,167227,1981,6418,5690,8125,9261,5693,8741,5685,5719,5687,51010,7314,7534,5720,3184,10213,207,5696,1432,23016,5698,23404,26986,5704,5695,5691,7514,22894,5714,55802,3312	PSMF1,PSME3,PSMC1,PSMB4,PSMB10,MAPK11,UBA52,NUP214,PSMA3,HSPB1,PSMB11,PSMA8,EXOSC9,PSMD4,XRN1,EXOSC5,PRKCD,PARN,SEM1,UBC,ZFP36,PSME4,PSMD7,PRKCA,PSMD11,PSMC6,PSMD9,PSMA1,YWHAB,EXOSC6,PSMB6,PSMD6,PSMD2,PSMD5,PSMD1,TNPO1,ELAVL1,RPS27A,PSMD12,MIR3940,PSMC2,KHSRP,PSMC3,ZFP36L1,PSMA5,EXOSC8,DCP2,EIF4G1,SET,PSMB2,ANP32A,MAPKAPK2,PSMB5,TNFSF13,PSMA4,PSMD13,PSMA6,EXOSC3,UBB,YWHAZ,PSME1,HNRNPD,PSMD14,AKT1,PSMB8,MAPK14,EXOSC7,PSMB9,EXOSC2,PABPC1,PSMC4,PSMB7,PSMB3,XPO1,DIS3,PSMD8,DCP1A,HSPA8
R-HSA-204998	Cell death signalling via NRAGE, NRIF and NADE	0.791491938478634	-0.233835584831531	76	65	0.00719504095638698	9034	10285	26084,5924,29,10018,100271715,9639,23263,6655,50650,5599,27237,84033,51107,128272,26230,5879,23365,50649,23370,10451,7189,23385,4803,22899,7409,7314,8874,9181,83464,9826,1894,121512,9828,23421,4804,6654,221472,55160,6453,6233,25791,26574,836,7074,84904,10672,7410,7311,835,89846,445328,7531,7204,389337,57449,7984,8997,55701,7316,9138,10276,8878,57580,5664,11214	ARHGEF26,RASGRF2,ABR,BCL2L11,ARHGEF33,ARHGEF10,MCF2L,SOS2,ARHGEF3,MAPK8,ARHGEF16,OBSCN,APH1A,ARHGEF19,TIAM2,RAC1,ARHGEF12,ARHGEF4,ARHGEF18,VAV3,TRAF6,NCSTN,NGF,ARHGEF15,VAV1,UBB,ARHGEF7,ARHGEF2,APH1B,ARHGEF11,ECT2,FGD4,ARHGEF17,ITGB3BP,NGFR,SOS1,FGD2,ARHGEF10L,ITSN1,RPS27A,NGEF,AATF,CASP3,TIAM1,ARHGEF39,GNA13,VAV2,UBA52,CASP2,FGD3,ARHGEF35,YWHAE,TRIO,ARHGEF37,PLEKHG5,ARHGEF5,KALRN,ARHGEF40,UBC,ARHGEF1,NET1,SQSTM1,PREX1,PSEN2,AKAP13
R-HSA-176409	APC/C:Cdc20 mediated degradation of mitotic proteins	0.791491938478634	-0.233835584831531	76	65	0.00719504095638698	9034	10285	5695,7321,5691,890,991,8697,51433,5714,9232,5720,8900,10213,5696,891,5698,5704,5687,5719,5685,7314,119504,5686,4751,5702,51434,5690,5693,983,64682,10393,29945,4085,5707,6233,25906,5701,5718,5715,5682,5717,5706,701,11065,7324,5694,9861,5711,5708,143471,5710,7316,51529,7979,5713,23198,996,9491,5700,10197,7311,5692,5699,122706,9184,5684	PSMB7,UBE2D1,PSMB3,CCNA2,CDC20,CDC23,ANAPC5,PSMD8,PTTG1,PSME1,CCNA1,PSMD14,PSMB8,CCNB1,PSMB9,PSMC4,PSMA6,PSMD13,PSMA4,UBB,ANAPC16,PSMA5,NEK2,PSMC3,ANAPC7,PSMB2,PSMB5,CDK1,ANAPC1,ANAPC10,ANAPC4,MAD2L1,PSMD1,RPS27A,ANAPC15,PSMC2,PSMD12,PSMD9,PSMA1,PSMD11,PSMC6,BUB1B,UBE2C,UBE2E1,PSMB6,PSMD6,PSMD5,PSMD2,PSMA8,PSMD4,UBC,ANAPC11,SEM1,PSMD7,PSME4,CDC27,PSMF1,PSMC1,PSME3,UBA52,PSMB4,PSMB10,PSMB11,BUB3,PSMA3
R-HSA-1222556	ROS, RNS production in phagocytes	0.793820674547855	-0.230897693938507	33	28	0.00309940225813593	9034	10285	4688,245973,533,523,9114,526,4842,245972,23545,8992,90423,155066,528,51382,50617,9550,653361,100847046,4689,4846,127124,535,1535,525,6556,10312,529,51606	NCF2,ATP6V1C2,ATP6V0B,ATP6V1A,ATP6V0D1,ATP6V1B2,NOS1,ATP6V0D2,ATP6V0A2,ATP6V0E1,ATP6V1E2,ATP6V0E2,ATP6V1C1,ATP6V1D,ATP6V0A4,ATP6V1G1,NCF1,MIR5010,NCF4,NOS3,ATP6V1G3,ATP6V0A1,CYBA,ATP6V1B1,SLC11A1,TCIRG1,ATP6V1E1,ATP6V1H
R-HSA-202433	Generation of second messenger molecules	0.793820674547855	-0.230897693938507	33	28	0.00309940225813593	9034	10285	5062,9398,55740,3932,2533,916,51466,9402,3119,7408,4690,27040,3127,5058,3113,3702,3117,3122,3120,3123,7535,5335,915,917,919,3937,3118,920	PAK2,CD101,ENAH,LCK,FYB1,CD3E,EVL,GRAP2,HLA-DQB1,VASP,NCK1,LAT,HLA-DRB5,PAK1,HLA-DPA1,ITK,HLA-DQA1,HLA-DRA,HLA-DQB2,HLA-DRB1,ZAP70,PLCG1,CD3D,CD3G,CD247,LCP2,HLA-DQA2,CD4
R-HSA-1839126	FGFR2 mutant receptor activation	0.793820674547855	-0.230897693938507	33	28	0.00309940225813593	9034	10285	5434,4686,2962,2247,2253,8074,2252,2250,2963,5431,2246,22916,2248,5441,5433,5440,2254,8822,5432,5439,5430,8817,2263,2249,2251,26281,27006,2255	POLR2E,NCBP1,GTF2F1,FGF2,FGF8,FGF23,FGF7,FGF5,GTF2F2,POLR2B,FGF1,NCBP2,FGF3,POLR2L,POLR2D,POLR2K,FGF9,FGF17,POLR2C,POLR2J,POLR2A,FGF18,FGFR2,FGF4,FGF6,FGF20,FGF22,FGF10
R-HSA-5357905	Regulation of TNFR1 signaling	0.793820674547855	-0.230897693938507	33	28	0.00309940225813593	9034	10285	8887,841,7128,1147,7124,8717,330,6233,90268,56928,3551,329,8567,1540,7185,7311,9099,10616,8737,27005,56957,25999,7314,84888,10399,7132,7375,7316	TAX1BP1,CASP8,TNFAIP3,CHUK,TNF,TRADD,BIRC3,RPS27A,OTULIN,SPPL2B,IKBKB,BIRC2,MADD,CYLD,TRAF1,UBA52,USP2,RBCK1,RIPK1,USP21,OTUD7B,CLIP3,UBB,SPPL2A,RACK1,TNFRSF1A,USP4,UBC
R-HSA-3595174	Defective CHST14 causes EDS, musculocontractural type	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	10675,1462,63827,1634,1463,1464	CSPG5,VCAN,BCAN,DCN,NCAN,CSPG4
R-HSA-447038	NrCAM interactions	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	8828,1742,1739,286,6900,4897	NRP2,DLG4,DLG1,ANK1,CNTN2,NRCAM
R-HSA-163767	PP2A-mediated dephosphorylation of key metabolic factors	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	5528,5518,51085,5515,5516,5519	PPP2R5D,PPP2R1A,MLXIPL,PPP2CA,PPP2CB,PPP2R1B
R-HSA-2393930	Phosphate bond hydrolysis by NUDT proteins	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	131870,79873,55270,4521,11164,53343	NUDT16,NUDT18,NUDT15,NUDT1,NUDT5,NUDT9
R-HSA-5619102	SLC transporter disorders	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	2645,2646,553,552,551,213	GCK,GCKR,AVPR1B,AVPR1A,AVP,ALB
R-HSA-6814848	Glycerophospholipid catabolism	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	81544,10908,133121,79153,284161,51573	GDPD5,PNPLA6,ENPP6,GDPD3,GDPD1,GDE1
R-HSA-3595172	Defective CHST3 causes SEDCJD	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	10675,1462,1463,1464,63827,1634	CSPG5,VCAN,NCAN,CSPG4,BCAN,DCN
R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	3516,6928,3175,50674,3280,390874	RBPJ,HNF1B,ONECUT1,NEUROG3,HES1,ONECUT3
R-HSA-3595177	Defective CHSY1 causes TPBS	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	1463,1464,1634,63827,1462,10675	NCAN,CSPG4,DCN,BCAN,VCAN,CSPG5
R-HSA-429593	Inositol transporters	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	114134,6526,115584,6527,200010,6523	SLC2A13,SLC5A3,SLC5A11,SLC5A4,SLC5A9,SLC5A1
R-HSA-5603029	IkBA variant leads to EDA-ID	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	1147,4791,4790,5970,4792,3551	CHUK,NFKB2,NFKB1,RELA,NFKBIA,IKBKB
R-HSA-196843	Vitamin B2 (riboflavin) metabolism	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	55065,80308,113278,5167,54,55312	SLC52A1,FLAD1,SLC52A3,ENPP1,ACP5,RFK
R-HSA-5576894	Phase 1 - inactivation of fast Na+ channels	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	3752,30819,30820,30818,3751,80333	KCND3,KCNIP2,KCNIP1,KCNIP3,KCND2,KCNIP4
R-HSA-110362	POLB-Dependent Long Patch Base Excision Repair	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	142,8505,5423,3978,10038,2237	PARP1,PARG,POLB,LIG1,PARP2,FEN1
R-HSA-174577	Activation of C3 and C5	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	717,100293534,727,720,629,718	C2,C4B_2,C5,C4A,CFB,C3
R-HSA-111471	Apoptotic factor-mediated response	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	54205,317,842,836,840,56616	CYCS,APAF1,CASP9,CASP3,CASP7,DIABLO
R-HSA-2993913	Clearance of Nuclear Envelope Membranes from Chromatin	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	8815,23592,221496,7443,7444,7112	BANF1,LEMD3,LEMD2,VRK1,VRK2,TMPO
R-HSA-199920	CREB phosphorylation	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	9252,1385,6196,6195,466,9261	RPS6KA5,CREB1,RPS6KA2,RPS6KA1,ATF1,MAPKAPK2
R-HSA-433692	Proton-coupled monocarboxylate transport	0.794456278014457	-0.230097325338426	7	6	0.000664157626743414	9034	10285	6566,23539,133418,682,9194,9123	SLC16A1,SLC16A8,EMB,BSG,SLC16A7,SLC16A3
R-HSA-169911	Regulation of Apoptosis	0.795597713498156	-0.228661605940391	54	46	0.00509187513836617	9034	10285	9861,5694,79658,5711,5708,5682,5715,5706,5717,115209,5701,5718,4976,5707,6233,122706,5684,5700,10197,9491,7311,5699,5692,7316,7979,5713,23198,5710,143471,5698,5704,5062,5720,5696,10213,5691,5714,5695,5693,5686,5702,5690,5687,5719,5685,7314	PSMD6,PSMB6,ARHGAP10,PSMD5,PSMD2,PSMA1,PSMD9,PSMC6,PSMD11,OMA1,PSMC2,PSMD12,OPA1,PSMD1,RPS27A,PSMB11,PSMA3,PSMC1,PSME3,PSMF1,UBA52,PSMB10,PSMB4,UBC,SEM1,PSMD7,PSME4,PSMD4,PSMA8,PSMB9,PSMC4,PAK2,PSME1,PSMB8,PSMD14,PSMB3,PSMD8,PSMB7,PSMB5,PSMA5,PSMC3,PSMB2,PSMA6,PSMD13,PSMA4,UBB
R-HSA-69610	p53-Independent DNA Damage Response	0.795597713498156	-0.228661605940391	54	46	0.00509187513836617	9034	10285	5707,6233,5701,5718,5682,5715,5706,5717,9861,5694,5711,5708,5710,143471,7316,7979,5713,23198,5700,10197,9491,7311,5699,5692,122706,5684,5695,5691,5714,11200,5720,5696,10213,5698,5704,5687,5719,5685,7314,993,5686,1111,5702,5690,472,5693	PSMD1,RPS27A,PSMC2,PSMD12,PSMA1,PSMD9,PSMC6,PSMD11,PSMD6,PSMB6,PSMD5,PSMD2,PSMD4,PSMA8,UBC,SEM1,PSMD7,PSME4,PSMC1,PSME3,PSMF1,UBA52,PSMB10,PSMB4,PSMB11,PSMA3,PSMB7,PSMB3,PSMD8,CHEK2,PSME1,PSMB8,PSMD14,PSMB9,PSMC4,PSMA6,PSMD13,PSMA4,UBB,CDC25A,PSMA5,CHEK1,PSMC3,PSMB2,ATM,PSMB5
R-HSA-69613	p53-Independent G1/S DNA damage checkpoint	0.795597713498156	-0.228661605940391	54	46	0.00509187513836617	9034	10285	5693,5684,122706,9491,5702,10197,5700,1111,5686,5692,472,5690,5699,7311,7316,7979,993,5713,23198,143471,5710,5719,5685,5687,7314,5698,5694,9861,5708,5711,5704,5717,5706,5720,5715,5682,10213,5696,5691,5718,11200,5714,5701,5707,5695,6233	PSMB5,PSMA3,PSMB11,PSMF1,PSMC3,PSME3,PSMC1,CHEK1,PSMA5,PSMB4,ATM,PSMB2,PSMB10,UBA52,UBC,SEM1,CDC25A,PSMD7,PSME4,PSMA8,PSMD4,PSMD13,PSMA4,PSMA6,UBB,PSMB9,PSMB6,PSMD6,PSMD2,PSMD5,PSMC4,PSMD11,PSMC6,PSME1,PSMD9,PSMA1,PSMD14,PSMB8,PSMB3,PSMD12,CHEK2,PSMD8,PSMC2,PSMD1,PSMB7,RPS27A
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	0.795597713498156	-0.228661605940391	54	46	0.00509187513836617	9034	10285	5699,5692,7311,5700,10197,9491,5684,122706,5710,143471,23198,5713,7316,7979,5706,5717,5682,5715,5708,5711,9861,5694,6233,5707,5718,5701,5690,472,1111,5702,5686,5693,7314,5719,5685,5687,993,5696,10213,5720,5704,5698,5695,11200,5714,5691	PSMB10,PSMB4,UBA52,PSMC1,PSME3,PSMF1,PSMA3,PSMB11,PSMD4,PSMA8,PSME4,PSMD7,UBC,SEM1,PSMC6,PSMD11,PSMA1,PSMD9,PSMD2,PSMD5,PSMD6,PSMB6,RPS27A,PSMD1,PSMD12,PSMC2,PSMB2,ATM,CHEK1,PSMC3,PSMA5,PSMB5,UBB,PSMD13,PSMA4,PSMA6,CDC25A,PSMB8,PSMD14,PSME1,PSMC4,PSMB9,PSMB7,CHEK2,PSMD8,PSMB3
R-HSA-1638091	Heparan sulfate/heparin (HS-GAG) metabolism	0.795597713498156	-0.228661605940391	54	46	0.00509187513836617	9034	10285	64131,11285,2990,3425,26229,2262,3339,9653,3340,1463,9394,10082,222537,126792,6382,11046,135152,79411,2131,64132,9951,2132,1464,64579,266722,2720,26035,10675,9955,9957,63827,9672,60495,10855,9348,6385,9956,64711,1634,6383,6448,375790,1462,9953,2817,27087	XYLT1,B4GALT7,GUSB,IDUA,B3GAT3,GPC5,HSPG2,HS2ST1,NDST1,NCAN,HS6ST1,GPC6,HS3ST5,B3GALT6,SDC1,SLC35D2,B3GAT2,GLB1L,EXT1,XYLT2,HS3ST4,EXT2,CSPG4,NDST4,HS6ST3,GLB1,GLCE,CSPG5,HS3ST3A1,HS3ST1,BCAN,SDC3,HPSE2,HPSE,NDST3,SDC4,HS3ST2,HS3ST6,DCN,SDC2,SGSH,AGRN,VCAN,HS3ST3B1,GPC1,B3GAT1
R-HSA-2995410	Nuclear Envelope Reassembly	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	4001,7112,5518,5520,5515,8815,221496,23592,4000,7444,7443	LMNB1,TMPO,PPP2R1A,PPP2R2A,PPP2CA,BANF1,LEMD2,LEMD3,LMNA,VRK2,VRK1
R-HSA-2995383	Initiation of Nuclear Envelope Reformation	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	4001,7112,5518,5520,5515,8815,221496,23592,4000,7444,7443	LMNB1,TMPO,PPP2R1A,PPP2R2A,PPP2CA,BANF1,LEMD2,LEMD3,LMNA,VRK2,VRK1
R-HSA-400511	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	2864,23478,60559,2626,2695,3670,1803,5122,9789,90701,5080	FFAR1,SEC11A,SPCS3,GATA4,GIP,ISL1,DPP4,PCSK1,SPCS2,SEC11C,PAX6
R-HSA-112308	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	10369,773,785,55799,784,777,27092,11094,783,781,9254	CACNG2,CACNA1A,CACNB4,CACNA2D3,CACNB3,CACNA1E,CACNG4,CACFD1,CACNB2,CACNA2D1,CACNA2D2
R-HSA-2892247	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	6774,5460,2649,2247,6997,55211,6657,27022,57167,79923,6299	STAT3,POU5F1,NR6A1,FGF2,CRIPTO,DPPA4,SOX2,FOXD3,SALL4,NANOG,SALL1
R-HSA-175474	Assembly Of The HIV Virion	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	5045,7314,7311,6233,137492,9397,5478,79720,7251,7316,55048	FURIN,UBB,UBA52,RPS27A,VPS37A,NMT2,PPIA,VPS37B,TSG101,UBC,VPS37C
R-HSA-2408517	SeMet incorporation into proteins	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	3376,7965,5917,5859,9255,51520,4141,2058,1615,9521,3735	IARS1,AIMP2,RARS1,QARS1,AIMP1,LARS1,MARS1,EPRS1,DARS1,EEF1E1,KARS1
R-HSA-113501	Inhibition of replication initiation of damaged DNA by RB1/E2F1	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	5519,5516,23649,5557,5518,7029,5515,5925,1869,7027,5558	PPP2R1B,PPP2CB,POLA2,PRIM1,PPP2R1A,TFDP2,PPP2CA,RB1,E2F1,TFDP1,PRIM2
R-HSA-879415	Advanced glycosylation endproduct receptor signaling	0.795959101543281	-0.228207474428503	13	11	0.00121762231569626	9034	10285	1650,3958,5589,3146,5594,6283,5595,6288,351,830,177	DDOST,LGALS3,PRKCSH,HMGB1,MAPK1,S100A12,MAPK3,SAA1,APP,CAPZA2,AGER
R-HSA-912694	Regulation of IFNA signaling	0.797651772878222	-0.226083151610857	26	22	0.00243524463139252	9034	10285	3449,3440,3442,3439,3448,3455,5770,3443,3716,3444,3454,3445,9021,6772,5781,6773,7297,8651,3452,3456,5777,3441	IFNA16,IFNA2,IFNA5,IFNA1,IFNA14,IFNAR2,PTPN1,IFNA6,JAK1,IFNA7,IFNAR1,IFNA8,SOCS3,STAT1,PTPN11,STAT2,TYK2,SOCS1,IFNA21,IFNB1,PTPN6,IFNA4
R-HSA-1971475	A tetrasaccharide linker sequence is required for GAG synthesis	0.797651772878222	-0.226083151610857	26	22	0.00243524463139252	9034	10285	9672,3339,63827,6385,11285,64131,64132,1464,10675,2262,26229,2817,135152,27087,10082,1634,1463,6383,1462,6382,375790,126792	SDC3,HSPG2,BCAN,SDC4,B4GALT7,XYLT1,XYLT2,CSPG4,CSPG5,GPC5,B3GAT3,GPC1,B3GAT2,B3GAT1,GPC6,DCN,NCAN,SDC2,VCAN,SDC1,AGRN,B3GALT6
R-HSA-3560782	Diseases associated with glycosaminoglycan metabolism	0.797651772878222	-0.226083151610857	26	22	0.00243524463139252	9034	10285	3339,63827,4958,176,2817,9672,2331,4060,6385,5549,1634,1464,1463,6383,11081,10082,4969,10675,1462,6382,375790,2262	HSPG2,BCAN,OMD,ACAN,GPC1,SDC3,FMOD,LUM,SDC4,PRELP,DCN,CSPG4,NCAN,SDC2,KERA,GPC6,OGN,CSPG5,VCAN,SDC1,AGRN,GPC5
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	0.798114414895148	-0.225503314748248	61	52	0.00575603276510959	9034	10285	5686,5702,4791,8454,5690,5693,5687,5719,5685,7314,5720,10213,5696,6500,5698,5704,5695,5691,5714,9491,5700,10197,7311,5692,5699,122706,5684,143471,5971,5710,7979,7316,23198,5713,5715,5682,1147,5717,5706,9020,5694,9861,5970,5711,8945,5708,23291,5707,6233,9039,5701,5718	PSMA5,PSMC3,NFKB2,CUL1,PSMB2,PSMB5,PSMA6,PSMD13,PSMA4,UBB,PSME1,PSMD14,PSMB8,SKP1,PSMB9,PSMC4,PSMB7,PSMB3,PSMD8,PSMF1,PSMC1,PSME3,UBA52,PSMB4,PSMB10,PSMB11,PSMA3,PSMA8,RELB,PSMD4,SEM1,UBC,PSME4,PSMD7,PSMD9,PSMA1,CHUK,PSMD11,PSMC6,MAP3K14,PSMB6,PSMD6,RELA,PSMD5,BTRC,PSMD2,FBXW11,PSMD1,RPS27A,UBA3,PSMC2,PSMD12
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	0.798114414895148	-0.225503314748248	61	52	0.00575603276510959	9034	10285	5706,5717,5682,5715,6502,9861,5694,5708,5711,5707,595,6233,5718,5701,10197,5700,9491,5699,5692,7311,5684,1017,5710,7316,7979,898,5713,8900,5720,5696,10213,5698,6500,5704,1026,5695,5691,890,1019,1027,5714,8454,5702,5686,5690,5693,5753,5719,5685,5687,7314,9134	PSMC6,PSMD11,PSMA1,PSMD9,SKP2,PSMD6,PSMB6,PSMD2,PSMD5,PSMD1,CCND1,RPS27A,PSMD12,PSMC2,PSME3,PSMC1,PSMF1,PSMB10,PSMB4,UBA52,PSMA3,CDK2,PSMD4,UBC,SEM1,CCNE1,PSMD7,CCNA1,PSME1,PSMB8,PSMD14,PSMB9,SKP1,PSMC4,CDKN1A,PSMB7,PSMB3,CCNA2,CDK4,CDKN1B,PSMD8,CUL1,PSMC3,PSMA5,PSMB2,PSMB5,PTK6,PSMD13,PSMA4,PSMA6,UBB,CCNE2
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	0.799697820086426	-0.223521347562193	90	77	0.00852335620987381	9034	10285	7311,5577,1639,80321,5048,22919,7531,23354,7277,4218,5347,121441,95681,22995,9814,203068,7316,1778,55722,5566,10133,93323,4957,79441,9662,8945,1781,54801,22897,10806,115106,80254,5108,6233,54820,23291,22981,79866,4659,10142,9133,1454,80184,4751,8454,4660,11190,5518,3320,983,11258,55125,7314,7846,10121,9793,9702,54930,22994,1453,6790,10382,84131,84962,11064,23332,6500,891,79959,55755,7840,10733,7532,5500,55835,10540,8655	UBA52,PRKAR2B,DCTN1,CEP70,PAFAH1B1,MAPRE1,YWHAE,HAUS5,TUBA4A,RAB8A,PLK1,NEDD1,CEP41,CEP152,SFI1,TUBB,UBC,DYNC1H1,CEP72,PRKACA,OPTN,HAUS8,ODF2,HAUS3,CEP135,BTRC,DYNC1I2,HAUS6,CEP164,SDCCAG8,HAUS1,CEP63,PCM1,RPS27A,NDE1,FBXW11,NINL,BORA,PPP1R12A,AKAP9,CCNB2,CSNK1E,CEP290,NEK2,CUL1,PPP1R12B,CEP250,PPP2R1A,HSP90AA1,CDK1,DCTN3,CEP192,UBB,TUBA1A,ACTR1A,CKAP5,CEP57,HAUS4,CEP131,CSNK1D,AURKA,TUBB4A,CEP78,AJUBA,CNTRL,CLASP1,SKP1,CCNB1,CEP76,CDK5RAP2,ALMS1,PLK4,YWHAG,PPP1CB,CENPJ,DCTN2,DYNLL1
R-HSA-5696398	Nucleotide Excision Repair	0.8017338098734	-0.220978634097766	112	96	0.0106265220278946	9034	10285	2074,5432,10450,8451,9557,5440,7316,54107,7329,5427,10987,902,5985,8607,7515,1161,93973,6117,9716,56655,85015,7508,6917,10038,2873,10445,5430,8554,8533,2071,100302237,2967,1642,2965,6612,7528,5982,7334,57461,2073,10714,9318,8178,3980,2068,7341,50813,5439,9978,5983,7311,6613,404672,2033,1643,1022,6233,5981,5111,7507,6118,5434,2072,7336,5886,283899,7874,5441,60,3150,5887,7314,54617,4798,6119,2968,5433,10920,51426,64708,57804,79913,3978,51138,125476,2067,5984,86,91603,54778,142,4331,5431,5424,54891,57654	ERCC6,POLR2C,PPIE,CUL4A,CHD1L,POLR2K,UBC,POLE3,UBE2I,POLE2,COPS5,CCNH,RFC5,RUVBL1,XRCC1,ERCC8,ACTR8,RPA1,AQR,POLE4,USP45,XPC,TCEA1,PARP2,GPS1,MCRS1,POLR2A,PIAS1,COPS3,ERCC3,MIR1281,GTF2H3,DDB1,GTF2H1,SUMO3,YY1,RFC2,UBE2N,ISY1,ERCC5,POLD3,COPS2,ELL,LIG3,ERCC2,SUMO1,COPS7A,POLR2J,RBX1,RFC3,UBA52,SUMO2,GTF2H5,EP300,DDB2,CDK7,RPS27A,RFC1,PCNA,XPA,RPA2,POLR2E,ERCC4,UBE2V2,RAD23A,INO80E,USP7,POLR2L,ACTB,HMGN1,RAD23B,UBB,INO80,NFRKB,RPA3,GTF2H4,POLR2D,COPS8,POLK,COPS7B,POLD4,ACTR5,LIG1,COPS4,INO80C,ERCC1,RFC4,ACTL6A,ZNF830,RNF111,PARP1,MNAT1,POLR2B,POLD1,INO80D,UVSSA
R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	0.807013234634692	-0.214415211051506	19	16	0.0017710870046491	9034	10285	5393,56915,51010,5073,7534,22894,8570,100500888,11340,167227,5600,207,118460,23016,1432,23404	EXOSC9,EXOSC5,EXOSC3,PARN,YWHAZ,DIS3,KHSRP,MIR3940,EXOSC8,DCP2,MAPK11,AKT1,EXOSC6,EXOSC7,MAPK14,EXOSC2
R-HSA-176412	Phosphorylation of the APC/C	0.807013234634692	-0.214415211051506	19	16	0.0017710870046491	9034	10285	7321,25906,5347,119504,51433,996,8697,51529,51434,11065,7324,29945,10393,983,64682,891	UBE2D1,ANAPC15,PLK1,ANAPC16,ANAPC5,CDC27,CDC23,ANAPC11,ANAPC7,UBE2C,UBE2E1,ANAPC4,ANAPC10,CDK1,ANAPC1,CCNB1
R-HSA-8876725	Protein methylation	0.807013234634692	-0.214415211051506	19	16	0.0017710870046491	9034	10285	79609,805,254013,79823,808,1938,801,221143,10196,196483,3312,1915,151194,7415,22944,79091	VCPKMT,CALM2,ETFBKMT,CAMKMT,CALM3,EEF2,CALM1,EEF1AKMT1,PRMT3,EEF2KMT,HSPA8,EEF1A1,METTL21A,VCP,KIN,METTL22
R-HSA-202430	Translocation of ZAP-70 to Immunological synapse	0.807013234634692	-0.214415211051506	19	16	0.0017710870046491	9034	10285	7535,3123,3932,3122,3120,916,3117,920,3113,3118,917,919,915,3127,3119,26191	ZAP70,HLA-DRB1,LCK,HLA-DRA,HLA-DQB2,CD3E,HLA-DQA1,CD4,HLA-DPA1,HLA-DQA2,CD3G,CD247,CD3D,HLA-DRB5,HLA-DQB1,PTPN22
R-HSA-190861	Gap junction assembly	0.807013234634692	-0.214415211051506	19	16	0.0017710870046491	9034	10285	2702,2709,2700,2706,10804,2703,2697,219770,57369,127534,125111,10052,2707,84694,57165,2701	GJA5,GJB5,GJA3,GJB2,GJB6,GJA8,GJA1,GJD4,GJD2,GJB4,GJD3,GJC1,GJB3,GJA10,GJC2,GJA4
R-HSA-176407	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	0.807013234634692	-0.214415211051506	19	16	0.0017710870046491	9034	10285	51529,991,8697,51433,119504,996,8556,51343,25906,7321,64682,10393,29945,11065,51434,7324	ANAPC11,CDC20,CDC23,ANAPC5,ANAPC16,CDC27,CDC14A,FZR1,ANAPC15,UBE2D1,ANAPC1,ANAPC10,ANAPC4,UBE2C,ANAPC7,UBE2E1
R-HSA-68875	Mitotic Prophase	0.809906019927694	-0.210837062827673	141	121	0.0133938454726588	9034	10285	8348,7444,121504,8366,9883,8021,8334,8086,8341,8370,5347,8367,9631,8365,126961,3018,8353,4928,5578,255919,5519,8343,23636,8339,64689,10762,8360,54892,8548,3013,10051,5861,8968,57122,653604,9133,10776,55746,8358,8344,221496,23310,6418,10592,983,3020,64900,5518,11097,84930,8815,8359,10783,8290,5594,9818,128312,5903,8362,7443,140609,4000,23279,8349,23511,5579,23225,9972,79648,26003,8354,4927,5595,8368,3015,3017,8346,94239,8350,81929,8361,7175,8345,2029,129401,8347,8355,81876,8970,8357,2801,8615,8363,348995,8340,79902,5925,7112,5516,723790,5862,8364,79023,23592,8335,8352,55706,5515,9688,91754,4001,100101267,23165,9663,891,387893,23175,55766,53371,3021,3012	H2BC17,VRK2,H4C16,H4C2,POM121,NUP214,H2AC6,AAAS,H2BC15,H4C14,PLK1,H4C5,NUP155,H4C8,H3C14,H2BC3,H3C6,NUP98,PRKCA,CNEP1R1,PPP2R1B,H2BC7,NUP62,H2BC8,GORASP1,NUP50,H4C4,NCAPG2,BLZF1,H2AC7,SMC4,RAB1A,H3C7,NUP107,H3C13,CCNB2,ARPP19,NUP133,H3C2,H2BC6,LEMD2,NCAPD3,SET,SMC2,CDK1,H3-3A,LPIN3,PPP2R1A,NUP42,MASTL,BANF1,H4C1,NEK6,H3-4,MAPK1,NUP58,H2BC26,RANBP2,H4C12,VRK1,NEK7,LMNA,NUP160,H2BC21,NUP188,PRKCB,NUP210,NUP153,MCPH1,GORASP2,H3C11,NUP88,MAPK3,H4C13,H2AZ1,H2BC5,H2BC10,H2AZ2,H3C1,SEH1L,H4C6,TPR,H2BC9,ENSA,NUP35,H2BC4,H3C8,RAB1B,H2BC11,H3C10,GOLGA2,USO1,H4C11,NUP43,H2BC13,NUP85,RB1,TMPO,PPP2CB,H2AC19,RAB2A,H4C3,NUP37,LEMD3,H2AC4,H3C3,NDC1,PPP2CA,NUP93,NEK9,LMNB1,POM121C,NUP205,LPIN2,CCNB1,KMT5A,LPIN1,H2AJ,NUP54,H3-3B,H2AC8
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	0.810692014306295	-0.209867057405443	53	45	0.0049811822005756	9034	10285	9491,10197,5700,7311,5692,5699,122706,5684,143471,5710,7979,7316,5713,23198,7157,5715,5682,5717,5706,5694,9861,5711,5708,5707,6233,5701,5718,5686,5702,472,5690,5693,5687,5719,5685,7314,5720,10213,5696,5698,64326,5704,5695,5691,5714	PSMF1,PSME3,PSMC1,UBA52,PSMB4,PSMB10,PSMB11,PSMA3,PSMA8,PSMD4,SEM1,UBC,PSMD7,PSME4,TP53,PSMD9,PSMA1,PSMD11,PSMC6,PSMB6,PSMD6,PSMD5,PSMD2,PSMD1,RPS27A,PSMC2,PSMD12,PSMA5,PSMC3,ATM,PSMB2,PSMB5,PSMA6,PSMD13,PSMA4,UBB,PSME1,PSMD14,PSMB8,PSMB9,COP1,PSMC4,PSMB7,PSMB3,PSMD8
R-HSA-180534	Vpu mediated degradation of CD4	0.810692014306295	-0.209867057405443	53	45	0.0049811822005756	9034	10285	5700,10197,9491,7311,5699,5692,122706,5684,5710,143471,920,7979,7316,23198,5713,5682,5715,5706,5717,9861,5694,8945,5711,5708,5707,6233,5701,5718,5686,5702,5690,5693,5687,5685,5719,7314,5720,5696,10213,6500,5698,5704,5695,5691,5714	PSMC1,PSME3,PSMF1,UBA52,PSMB10,PSMB4,PSMB11,PSMA3,PSMD4,PSMA8,CD4,SEM1,UBC,PSME4,PSMD7,PSMA1,PSMD9,PSMC6,PSMD11,PSMD6,PSMB6,BTRC,PSMD5,PSMD2,PSMD1,RPS27A,PSMC2,PSMD12,PSMA5,PSMC3,PSMB2,PSMB5,PSMA6,PSMA4,PSMD13,UBB,PSME1,PSMB8,PSMD14,SKP1,PSMB9,PSMC4,PSMB7,PSMB3,PSMD8
R-HSA-5696394	DNA Damage Recognition in GG-NER	0.81073206200465	-0.209817659226463	39	33	0.00365286694708878	9034	10285	93973,86,283899,7508,5887,54891,60,142,51138,79913,6233,8607,5886,125476,9318,10987,1643,8533,7311,7528,64708,1642,8451,4798,2873,50813,10445,7314,54617,10038,7316,9978,10920	ACTR8,ACTL6A,INO80E,XPC,RAD23B,INO80D,ACTB,PARP1,COPS4,ACTR5,RPS27A,RUVBL1,RAD23A,INO80C,COPS2,COPS5,DDB2,COPS3,UBA52,YY1,COPS7B,DDB1,CUL4A,NFRKB,GPS1,COPS7A,MCRS1,UBB,INO80,PARP2,UBC,RBX1,COPS8
R-HSA-193648	NRAGE signals death through JNK	0.812178708825176	-0.208034878275489	60	51	0.00564533982731902	9034	10285	84033,27237,5599,5879,26230,128272,100271715,29,10018,5924,26084,50650,23263,6655,9639,7409,22899,9181,8874,50649,23365,4803,10451,23370,6453,55160,6654,221472,26574,25791,1894,9826,9828,4804,121512,8997,7984,57449,11214,57580,10276,9138,55701,7410,10672,84904,7074,389337,7204,89846,445328	OBSCN,ARHGEF16,MAPK8,RAC1,TIAM2,ARHGEF19,ARHGEF33,ABR,BCL2L11,RASGRF2,ARHGEF26,ARHGEF3,MCF2L,SOS2,ARHGEF10,VAV1,ARHGEF15,ARHGEF2,ARHGEF7,ARHGEF4,ARHGEF12,NGF,VAV3,ARHGEF18,ITSN1,ARHGEF10L,SOS1,FGD2,AATF,NGEF,ECT2,ARHGEF11,ARHGEF17,NGFR,FGD4,KALRN,ARHGEF5,PLEKHG5,AKAP13,PREX1,NET1,ARHGEF1,ARHGEF40,VAV2,GNA13,ARHGEF39,TIAM1,ARHGEF37,TRIO,FGD3,ARHGEF35
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	0.812178708825176	-0.208034878275489	60	51	0.00564533982731902	9034	10285	5719,5685,5687,7314,5702,4791,8454,5686,5690,5693,5695,5691,5714,5720,10213,5696,5698,6500,5704,143471,5971,5710,7316,7979,5713,23198,9491,10197,5700,5692,5699,7311,5684,122706,5707,23291,9039,6233,5718,5701,5717,1147,5706,5715,5682,9020,5694,9861,5708,5711,8945	PSMD13,PSMA4,PSMA6,UBB,PSMC3,NFKB2,CUL1,PSMA5,PSMB2,PSMB5,PSMB7,PSMB3,PSMD8,PSME1,PSMD14,PSMB8,PSMB9,SKP1,PSMC4,PSMA8,RELB,PSMD4,UBC,SEM1,PSMD7,PSME4,PSMF1,PSME3,PSMC1,PSMB4,PSMB10,UBA52,PSMA3,PSMB11,PSMD1,FBXW11,UBA3,RPS27A,PSMD12,PSMC2,PSMD11,CHUK,PSMC6,PSMD9,PSMA1,MAP3K14,PSMB6,PSMD6,PSMD2,PSMD5,BTRC
R-HSA-168638	NOD1/2 Signaling Pathway	0.813489829474834	-0.206421854583332	32	27	0.00298870932034536	9034	10285	1540,329,3551,6885,10392,834,7334,330,5608,7335,83737,1147,23118,7128,841,1432,64127,842,3656,835,8767,837,5603,7189,10454,5600,6300	CYLD,BIRC2,IKBKB,MAP3K7,NOD1,CASP1,UBE2N,BIRC3,MAP2K6,UBE2V1,ITCH,CHUK,TAB2,TNFAIP3,CASP8,MAPK14,NOD2,CASP9,IRAK2,CASP2,RIPK2,CASP4,MAPK13,TRAF6,TAB1,MAPK11,MAPK12
R-HSA-4608870	Asymmetric localization of PCP proteins	0.814235491065941	-0.205505653755271	67	57	0.00630949745406243	9034	10285	7314,5687,23513,5685,5719,8324,5690,5686,5702,5693,5695,8322,5714,5691,64750,7976,7855,5696,10213,5720,5704,1856,5698,2535,5710,143471,100126338,23198,5713,7316,7979,7311,5699,5692,8325,5700,10197,9491,8321,122706,57154,5684,6233,5707,57216,5701,5718,7474,5682,5715,5706,5717,144165,5711,5708,9861,5694	UBB,PSMA6,SCRIB,PSMA4,PSMD13,FZD7,PSMB2,PSMA5,PSMC3,PSMB5,PSMB7,FZD4,PSMD8,PSMB3,SMURF2,FZD3,FZD5,PSMB8,PSMD14,PSME1,PSMC4,DVL2,PSMB9,FZD2,PSMD4,PSMA8,MIR937,PSME4,PSMD7,UBC,SEM1,UBA52,PSMB10,PSMB4,FZD8,PSMC1,PSME3,PSMF1,FZD1,PSMB11,SMURF1,PSMA3,RPS27A,PSMD1,VANGL2,PSMC2,PSMD12,WNT5A,PSMA1,PSMD9,PSMC6,PSMD11,PRICKLE1,PSMD5,PSMD2,PSMD6,PSMB6
R-HSA-179419	APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	0.816678393747985	-0.202509904523163	74	63	0.00697365508080584	9034	10285	122706,5684,9184,5700,10197,9491,7311,5699,5692,7979,7316,51529,5713,23198,996,5710,143471,9861,5694,5711,5708,5682,5715,5706,5717,11065,701,7324,5701,5718,4085,5707,6233,25906,10393,5693,64682,983,29945,4751,5686,5702,51434,5690,119504,5687,5719,5685,7314,5698,5704,8900,5720,5696,10213,890,5691,991,8697,5714,51433,5695,7321	PSMB11,PSMA3,BUB3,PSMC1,PSME3,PSMF1,UBA52,PSMB10,PSMB4,SEM1,UBC,ANAPC11,PSMD7,PSME4,CDC27,PSMD4,PSMA8,PSMD6,PSMB6,PSMD5,PSMD2,PSMA1,PSMD9,PSMC6,PSMD11,UBE2C,BUB1B,UBE2E1,PSMC2,PSMD12,MAD2L1,PSMD1,RPS27A,ANAPC15,ANAPC10,PSMB5,ANAPC1,CDK1,ANAPC4,NEK2,PSMA5,PSMC3,ANAPC7,PSMB2,ANAPC16,PSMA6,PSMD13,PSMA4,UBB,PSMB9,PSMC4,CCNA1,PSME1,PSMB8,PSMD14,CCNA2,PSMB3,CDC20,CDC23,PSMD8,ANAPC5,PSMB7,UBE2D1
R-HSA-499943	Synthesis and interconversion of nucleotide di- and triphosphates	0.819767600847056	-0.198734392494214	25	21	0.00232455169360195	9034	10285	204,122481,2936,2987,25961,4833,4830,203,7295,221264,79077,6240,6241,1503,2745,26289,4831,50484,51727,205,7296	AK2,AK7,GSR,GUK1,NUDT13,NME4,NME1,AK1,TXN,AK9,DCTPP1,RRM1,RRM2,CTPS1,GLRX,AK5,NME2,RRM2B,CMPK1,AK4,TXNRD1
R-HSA-425410	Metal ion SLC transporters	0.819767600847056	-0.198734392494214	25	21	0.00232455169360195	9034	10285	7781,29985,1317,1356,6556,29986,148867,23516,283375,30061,25800,4891,254428,84102,57181,7779,55676,64924,64116,169026,7780	SLC30A3,SLC39A3,SLC31A1,CP,SLC11A1,SLC39A2,SLC30A7,SLC39A14,SLC39A5,SLC40A1,SLC39A6,SLC11A2,SLC41A1,SLC41A2,SLC39A10,SLC30A1,SLC30A6,SLC30A5,SLC39A8,SLC30A8,SLC30A2
R-HSA-977068	Termination of O-glycan biosynthesis	0.819767600847056	-0.198734392494214	25	21	0.00232455169360195	9034	10285	256435,143662,4588,200958,4583,4589,394263,6487,56667,6484,6483,727897,118430,94025,10610,10071,27090,4585,140453,6482,6480	ST6GALNAC3,MUC15,MUC6,MUC20,MUC2,MUC7,MUC21,ST3GAL3,MUC13,ST3GAL4,ST3GAL2,MUC5B,MUCL1,MUC16,ST6GALNAC2,MUC12,ST6GALNAC4,MUC4,MUC17,ST3GAL1,ST6GAL1
R-HSA-162588	Budding and maturation of HIV virion	0.819767600847056	-0.198734392494214	25	21	0.00232455169360195	9034	10285	55048,79720,27183,5478,91782,137492,7311,128866,10015,51534,7316,7251,92421,9525,25978,79643,7314,51510,51652,6233,23327	VPS37C,VPS37B,VPS4A,PPIA,CHMP7,VPS37A,UBA52,CHMP4B,PDCD6IP,VTA1,UBC,TSG101,CHMP4C,VPS4B,CHMP2B,CHMP6,UBB,CHMP5,CHMP3,RPS27A,NEDD4L
R-HSA-201681	TCF dependent signaling in response to WNT	0.820624993831093	-0.197689041442404	238	205	0.0226920522470666	9034	10285	1499,6423,79577,1452,8350,94239,8347,9978,27121,5713,8361,5699,25776,7311,2033,8325,5684,7089,6259,3015,9580,79412,7474,4041,8357,5706,27123,8340,5711,8363,7314,7091,5515,7473,90780,723790,5702,5516,8313,22943,343637,8364,84870,3021,4221,8322,89780,7483,5714,1857,3012,10213,1455,7088,8658,8452,3065,5698,7471,8365,50964,126961,8370,7316,121504,8366,9491,8348,10197,10524,8312,7015,8321,3013,5526,8358,5701,8323,1454,9101,8968,653604,8339,8395,5525,5715,5682,8945,57680,123169,8359,5685,8290,7534,6422,5690,100302237,5686,1387,10023,64750,4609,8362,128312,23072,8349,5704,440193,7479,55553,284654,8345,607,6597,6932,59352,9070,5700,9736,8346,3017,8368,6233,5707,5528,5718,64321,8355,8970,5694,8352,5529,5719,83999,8335,54361,11197,208,5693,55766,56998,2932,7855,1855,5691,7514,7478,207,1457,5720,81847,6657,1856,54894,3018,2535,8367,1459,143471,5710,8341,23198,8353,6659,283149,4040,7979,324,5692,26108,55366,122706,8334,59349,83595,8607,857,51339,8360,5717,5527,83439,5519,8343,5708,6662,6934,9861,5687,80319,51176,8549,1487,8344,5929,5518,3020,5695,340419,8354,80351,5696,84133,8295,7090	CTNNB1,SFRP2,CDC73,CSNK1A1,H3C1,H2AZ2,H2BC4,RBX1,DKK4,PSMD7,H4C6,PSMB10,CBY1,UBA52,EP300,FZD8,PSMA3,TLE2,RYK,H2AZ1,SOX13,KREMEN2,WNT5A,LRP5,H3C10,PSMC6,DKK2,H2BC13,PSMD5,H4C11,UBB,TLE4,PPP2CA,WNT3,PYGO2,H2AC19,PSMC3,PPP2CB,AXIN2,DKK1,RSPO4,H4C3,RSPO3,H3-3B,MEN1,FZD4,WNT3A,WNT9A,PSMD8,DVL3,H2AC8,PSMD14,CSNK1G2,TLE1,TNKS,CUL3,HDAC1,PSMB9,WNT1,H4C8,SOST,H3C14,H4C14,UBC,H4C16,H4C2,PSMF1,H2BC17,PSME3,KAT5,AXIN1,TERT,FZD1,H2AC7,PPP2R5B,H3C2,PSMC2,FZD6,CSNK1E,USP8,H3C7,H3C13,H2BC8,PIP5K1B,PPP2R5A,PSMD9,PSMA1,BTRC,CHD8,LEO1,H4C1,PSMA4,H3-4,YWHAZ,SFRP1,PSMB2,MIR1281,PSMA5,CREBBP,FRAT1,SMURF2,MYC,H4C12,H2BC26,HECW1,H2BC21,PSMC4,CCDC88C,WNT8B,SOX6,RSPO1,H2BC9,BCL9,SMARCA4,TCF7,LGR6,ASH2L,PSMC1,USP34,H2BC10,H2BC5,H4C13,RPS27A,PSMD1,PPP2R5D,PSMD12,SOX17,H3C8,H2BC11,PSMB6,H3C3,PPP2R5E,PSMD13,KREMEN1,H2AC4,WNT4,WIF1,AKT2,PSMB5,H2AJ,CTNNBIP1,GSK3B,FZD5,DVL1,PSMB3,XPO1,WNT8A,AKT1,CSNK2A1,PSME1,RNF146,SOX2,DVL2,RNF43,H2BC3,FZD2,H4C5,CSNK2A2,PSMA8,PSMD4,H2BC15,PSME4,H3C6,SOX4,BCL9L,LRP6,SEM1,APC,PSMB4,PYGO1,LGR4,PSMB11,H2AC6,KLHL12,SOX7,RUVBL1,CAV1,DACT1,H4C4,PSMD11,PPP2R5C,TCF7L1,PPP2R1B,H2BC7,PSMD2,SOX9,TCF7L2,PSMD6,PSMA6,CXXC4,LEF1,LGR5,CTBP1,H2BC6,RBBP5,PPP2R1A,H3-3A,PSMB7,RSPO2,H3C11,TNKS2,PSMB8,ZNRF3,TRRAP,TLE3
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	0.825278493732672	-0.192034381449954	52	44	0.00487048926278503	9034	10285	6233,595,5707,5701,5718,5715,5682,5717,5706,5711,5708,5694,9861,143471,5710,5713,23198,7316,7979,7311,5692,5699,9491,5700,10197,122706,5684,5695,5714,1019,5691,10213,5696,5720,5704,5698,7314,5687,5685,5719,5690,5686,5702,5693	RPS27A,CCND1,PSMD1,PSMC2,PSMD12,PSMD9,PSMA1,PSMD11,PSMC6,PSMD5,PSMD2,PSMB6,PSMD6,PSMA8,PSMD4,PSMD7,PSME4,UBC,SEM1,UBA52,PSMB4,PSMB10,PSMF1,PSMC1,PSME3,PSMB11,PSMA3,PSMB7,PSMD8,CDK4,PSMB3,PSMD14,PSMB8,PSME1,PSMC4,PSMB9,UBB,PSMA6,PSMA4,PSMD13,PSMB2,PSMA5,PSMC3,PSMB5
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	0.825278493732672	-0.192034381449954	52	44	0.00487048926278503	9034	10285	5687,5685,5719,5710,143471,7314,7979,7316,23198,5713,5686,10197,5700,5702,9491,7311,5699,5690,5692,5693,122706,5684,1017,5707,6233,5695,5691,5714,5701,5718,5682,5715,5720,5706,5717,5696,10213,9861,5694,990,5698,5711,5704,5708	PSMA6,PSMA4,PSMD13,PSMD4,PSMA8,UBB,SEM1,UBC,PSME4,PSMD7,PSMA5,PSME3,PSMC1,PSMC3,PSMF1,UBA52,PSMB10,PSMB2,PSMB4,PSMB5,PSMB11,PSMA3,CDK2,PSMD1,RPS27A,PSMB7,PSMB3,PSMD8,PSMC2,PSMD12,PSMA1,PSMD9,PSME1,PSMC6,PSMD11,PSMB8,PSMD14,PSMD6,PSMB6,CDC6,PSMB9,PSMD5,PSMC4,PSMD2
R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	0.825278493732672	-0.192034381449954	52	44	0.00487048926278503	9034	10285	5698,5704,5720,10213,5696,5691,5714,5695,5693,5702,5686,5690,5719,5685,5687,5694,9861,5708,5711,51686,5717,5706,5715,5682,1728,5718,5701,5707,5684,4946,122706,9491,5700,10197,5692,5699,7979,4953,51582,5713,23198,4947,143471,5710	PSMB9,PSMC4,PSME1,PSMD14,PSMB8,PSMB3,PSMD8,PSMB7,PSMB5,PSMC3,PSMA5,PSMB2,PSMD13,PSMA4,PSMA6,PSMB6,PSMD6,PSMD2,PSMD5,OAZ3,PSMD11,PSMC6,PSMD9,PSMA1,NQO1,PSMD12,PSMC2,PSMD1,PSMA3,OAZ1,PSMB11,PSMF1,PSMC1,PSME3,PSMB4,PSMB10,SEM1,ODC1,AZIN1,PSMD7,PSME4,OAZ2,PSMA8,PSMD4
R-HSA-69229	Ubiquitin-dependent degradation of Cyclin D1	0.825278493732672	-0.192034381449954	52	44	0.00487048926278503	9034	10285	7311,5692,5690,5699,5686,9491,5702,5700,10197,122706,5684,5693,7314,5687,143471,5685,5719,5710,23198,5713,7316,7979,10213,5696,5720,5715,5682,5717,5706,5711,5704,5708,5694,9861,5698,6233,5695,595,5707,5714,5701,5718,1019,5691	UBA52,PSMB4,PSMB2,PSMB10,PSMA5,PSMF1,PSMC3,PSMC1,PSME3,PSMB11,PSMA3,PSMB5,UBB,PSMA6,PSMA8,PSMA4,PSMD13,PSMD4,PSME4,PSMD7,UBC,SEM1,PSMD14,PSMB8,PSME1,PSMD9,PSMA1,PSMD11,PSMC6,PSMD5,PSMC4,PSMD2,PSMB6,PSMD6,PSMB9,RPS27A,PSMB7,CCND1,PSMD1,PSMD8,PSMC2,PSMD12,CDK4,PSMB3
R-HSA-4641258	Degradation of DVL	0.825784707774431	-0.191421183775681	59	50	0.00553464688952845	9034	10285	5693,5690,5702,5686,7314,5685,5719,5687,5704,8452,5698,1856,10213,5696,23072,5720,5714,1857,1855,5691,5695,5684,122706,5692,5699,7311,9491,10197,5700,9978,23198,5713,7316,7979,143471,5710,5708,5711,5694,9861,51339,5717,5706,5715,5682,5718,5701,6233,5707,59349	PSMB5,PSMB2,PSMC3,PSMA5,UBB,PSMA4,PSMD13,PSMA6,PSMC4,CUL3,PSMB9,DVL2,PSMD14,PSMB8,HECW1,PSME1,PSMD8,DVL3,DVL1,PSMB3,PSMB7,PSMA3,PSMB11,PSMB4,PSMB10,UBA52,PSMF1,PSME3,PSMC1,RBX1,PSME4,PSMD7,UBC,SEM1,PSMA8,PSMD4,PSMD2,PSMD5,PSMB6,PSMD6,DACT1,PSMD11,PSMC6,PSMD9,PSMA1,PSMD12,PSMC2,RPS27A,PSMD1,KLHL12
R-HSA-6782135	Dual incision in TC-NER	0.826996971544179	-0.18995424594317	66	56	0.00619880451627186	9034	10285	5427,6233,5981,5111,7507,5985,6118,2072,5434,902,6117,5441,7874,1161,56655,3150,9716,2074,5432,5439,8451,10450,7316,5440,9978,404672,2033,7311,5983,1022,54107,2073,57461,2067,10714,5984,2068,91603,57654,5431,4331,5424,6119,2968,5430,6917,7314,5433,2071,100302237,51426,57804,5982,2967,1642,2965	POLE2,RPS27A,RFC1,PCNA,XPA,RFC5,RPA2,ERCC4,POLR2E,CCNH,RPA1,POLR2L,USP7,ERCC8,POLE4,HMGN1,AQR,ERCC6,POLR2C,POLR2J,CUL4A,PPIE,UBC,POLR2K,RBX1,GTF2H5,EP300,UBA52,RFC3,CDK7,POLE3,ERCC5,ISY1,ERCC1,POLD3,RFC4,ERCC2,ZNF830,UVSSA,POLR2B,MNAT1,POLD1,RPA3,GTF2H4,POLR2A,TCEA1,UBB,POLR2D,ERCC3,MIR1281,POLK,POLD4,RFC2,GTF2H3,DDB1,GTF2H1
R-HSA-162599	Late Phase of HIV Life Cycle	0.827326696175544	-0.189555624268142	139	119	0.0131724595970777	9034	10285	6921,6873,8812,23636,904,6749,10762,57122,6881,2962,55746,902,9525,51652,6827,7936,9883,2959,8021,6883,5478,6923,7251,7316,5440,4928,905,8086,5432,162699,9631,5045,51224,22916,79720,23279,6884,23511,5903,6879,2958,2068,6924,10015,8178,100302168,2960,8732,4686,9972,23225,11198,6874,2967,2965,27183,2071,9818,5430,4836,11097,5901,100506888,6917,348995,5902,7469,5441,100302242,5434,79902,9397,6233,23327,1022,91782,100126332,4927,8731,6880,404672,1104,7311,128866,92421,7175,129401,5439,25978,51510,81929,6877,79643,6875,55048,5431,4331,138474,100101267,23165,83860,7514,51534,2957,2963,53371,79023,6882,137492,2961,9150,6829,51497,5905,5433,2968,55706,9688,7314	ELOC,TAF2,CCNK,NUP62,CCNT1,SSRP1,NUP50,NUP107,TAF10,GTF2F1,NUP133,CCNH,VPS4B,CHMP3,SUPT4H1,NELFE,POM121,GTF2B,NUP214,TAF12,PPIA,ELOB,TSG101,UBC,POLR2K,NUP98,CCNT2,AAAS,POLR2C,ELOA3P,NUP155,FURIN,ELOA2,NCBP2,VPS37B,NUP160,TAF13,NUP188,RANBP2,TAF7,GTF2A2,ERCC2,ELOA,PDCD6IP,ELL,MIR1257,GTF2E1,RNGTT,NCBP1,NUP153,NUP210,SUPT16H,TAF4,GTF2H3,GTF2H1,VPS4A,ERCC3,NUP58,POLR2A,NMT1,NUP42,RAN,ELOA3DP,TCEA1,NUP43,RANBP1,NELFA,POLR2L,MIR1236,POLR2E,NUP85,NMT2,RPS27A,NEDD4L,CDK7,CHMP7,MIR943,NUP88,RNMT,TAF9,GTF2H5,RCC1,UBA52,CHMP4B,CHMP4C,TPR,NUP35,POLR2J,CHMP2B,CHMP5,SEH1L,TAF5,CHMP6,TAF4B,VPS37C,POLR2B,MNAT1,TAF1L,POM121C,NUP205,TAF3,XPO1,VTA1,GTF2A1,GTF2F2,NUP54,NUP37,TAF11,VPS37A,GTF2E2,CTDP1,SUPT5H,NELFCD,RANGAP1,POLR2D,GTF2H4,NDC1,NUP93,UBB
R-HSA-3371511	HSF1 activation	0.828434135623696	-0.188217943617628	12	10	0.00110692937790569	9034	10285	6119,6117,7415,7531,10728,1915,3281,3326,3320,6118	RPA3,RPA1,VCP,YWHAE,PTGES3,EEF1A1,HSBP1,HSP90AB1,HSP90AA1,RPA2
R-HSA-6805567	Keratinization	0.828509538958228	-0.188126928653462	214	184	0.0203675005534647	9034	10285	4014,440050,147183,338785,112802,26239,3852,386681,83897,3884,11005,386679,386685,100131902,64065,1829,386683,26085,404203,254910,387264,121391,162605,85285,337973,386678,3881,3868,7051,100132386,3846,337975,1828,23581,3855,386677,83902,643394,337971,353288,337882,192666,286887,337960,3856,386676,1041,147409,3883,337959,386672,337974,643803,83895,337879,728279,337976,6700,337972,653240,386674,43847,140807,3872,144501,337977,54474,8502,440023,374454,353145,83901,823,728255,11187,85290,81872,63036,6707,3882,387266,337978,3854,3885,126638,3890,3886,84616,3853,6768,85280,3875,3860,284827,1832,3851,85294,337979,3713,386682,7062,57830,5045,337880,337967,342574,643812,337966,5046,1824,3728,337968,25818,353139,85289,196374,5493,8689,125115,3889,6701,353323,728318,439915,199834,3850,3888,3861,8688,353137,3857,6704,3891,353332,337969,51350,81851,43849,730755,11202,1823,1475,5318,728299,388818,6699,728224,83896,440051,100288323,3892,3859,5652,100132476,353131,1830,3849,2125,6705,353333,8687,3848,3866,1825,3887,25984,100533177,140258,100505753,85293,23254,5266,337963,319101,5317,9333,387273,85291,83899,337970,390792,3880,254950,3858	LORICRIN,KRTAP5-7,KRT25,KRT79,KRT71,LCE2B,KRT5,KRTAP10-8,KRTAP3-2,KRT33B,SPINK5,KRTAP10-2,KRTAP10-12,KRTAP25-1,PERP,DSG2,KRTAP12-3,KLK13,SPINK6,LCE5A,KRTAP5-1,KRT74,KRT28,KRTAP4-1,KRTAP19-6,KRTAP10-11,KRT31,KRT16,TGM1,KRTAP4-9,KRTAP5-9,KRTAP20-1,DSG1,CASP14,KRT7,KRTAP10-1,KRTAP17-1,SPINK9,KRTAP19-4,KRT26,KRTAP19-1,KRT24,KRT6C,KRTAP13-3,KRT8,KRTAP10-9,CDSN,DSG4,KRT33A,KRTAP13-2,KRTAP10-4,KRTAP19-7,KRTAP24-1,KRTAP1-5,KRTAP8-1,KRTAP2-2,KRTAP20-2,SPRR2A,KRTAP19-5,KRTAP4-11,KRTAP10-6,KLK14,KRT72,KRT17,KRT80,KRTAP21-1,KRT20,PKP4,KRTAP5-6,KRT77,LCE3E,KRTAP9-8,CAPN1,KRTAP1-4,PKP3,KRTAP4-3,KRTAP2-1,CELA2A,SPRR3,KRT32,KRTAP5-3,KRTAP21-2,KRT6B,KRT34,RPTN,KRT84,KRT35,KRTAP4-4,KRT6A,ST14,KRTAP9-4,KRT18,KRT13,KRTAP13-4,DSP,KRT4,KRTAP2-4,KRTAP22-1,IVL,KRTAP10-3,TCHH,KRTAP5-8,FURIN,KRTAP11-1,KRTAP6-2,KRT27,KRTAP27-1,KRTAP6-1,PCSK6,DSC2,JUP,KRTAP6-3,KLK5,LCE2A,KRTAP4-5,KRT78,PPL,KRT36,KRT40,KRT83,SPRR2B,KRTAP12-2,KRTAP9-1,KRTAP5-5,LCE4A,KRT3,KRT82,KRT14,KRT37,LCE1F,KRT9,SPRR2E,KRT85,KRTAP12-1,KRTAP19-2,KRT76,KRTAP1-1,KLK12,KRTAP2-3,KLK8,DSC1,CSTA,PKP2,KRTAP19-8,KRTAP26-1,SPRR1B,KRTAP4-8,KRTAP3-1,KRTAP5-11,KRTAP21-3,KRT86,KRT12,PRSS8,KRTAP4-7,LCE1A,DSG3,KRT2,EVPL,SPRR2F,KRTAP10-10,KRT38,KRT1,KRT15,DSC3,KRT81,KRT23,KRTAP29-1,KRTAP13-1,KRTAP16-1,KRTAP3-3,KAZN,PI3,KRTAP23-1,KRT73,PKP1,TGM5,KRTAP5-10,KRTAP4-2,KRTAP9-2,KRTAP19-3,KRT39,KRT19,KRTAP15-1,KRT10
R-HSA-3214841	PKMTs methylate histone lysines	0.828701876843311	-0.187894806325421	73	62	0.00686296214301528	9034	10285	653604,8968,8358,84193,8363,80854,23512,5970,8357,5928,2146,8355,64324,8360,64754,8361,121536,51111,8353,55904,8350,8370,84661,79918,126961,8365,8367,8368,54904,79723,11091,8366,56950,121504,9070,84787,4790,8354,55729,56979,693140,387893,83852,9757,8362,23067,2122,4297,29072,8359,8352,84444,10919,63976,55870,9869,58508,8364,5929,7468,8726,4791	H3C13,H3C7,H3C2,SETD3,H4C11,SETD7,SUZ12,RELA,H3C10,RBBP4,EZH2,H3C8,NSD1,H4C4,SMYD3,H4C6,AEBP2,KMT5B,H3C6,KMT2E,H3C1,H4C14,DPY30,SETD6,H3C14,H4C8,H4C5,H4C13,NSD3,SUV39H2,WDR5,H4C2,SMYD2,H4C16,ASH2L,KMT5C,NFKB1,H3C11,ATF7IP,PRDM9,MIR555,KMT5A,SETDB2,KMT2B,H4C12,SETD1B,MECOM,KMT2A,SETD2,H4C1,H3C3,DOT1L,EHMT2,PRDM16,ASH1L,SETDB1,KMT2C,H4C3,RBBP5,NSD2,EED,NFKB2
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	0.828701876843311	-0.187894806325421	73	62	0.00686296214301528	9034	10285	5710,5347,143471,5713,23198,996,7316,7979,51529,7311,5699,5692,10197,5700,9491,122706,5684,6233,25906,5707,5701,5718,11065,7324,5682,5715,5706,5717,5711,5708,9861,6502,5694,7314,5687,51343,5719,5685,119504,9212,6790,51434,5690,5686,5702,29945,10393,5693,64682,5695,7321,51433,9232,5714,5691,991,8697,5696,10213,5720,5704,5698	PSMD4,PLK1,PSMA8,PSMD7,PSME4,CDC27,UBC,SEM1,ANAPC11,UBA52,PSMB10,PSMB4,PSME3,PSMC1,PSMF1,PSMB11,PSMA3,RPS27A,ANAPC15,PSMD1,PSMC2,PSMD12,UBE2C,UBE2E1,PSMA1,PSMD9,PSMC6,PSMD11,PSMD5,PSMD2,PSMD6,SKP2,PSMB6,UBB,PSMA6,FZR1,PSMD13,PSMA4,ANAPC16,AURKB,AURKA,ANAPC7,PSMB2,PSMA5,PSMC3,ANAPC4,ANAPC10,PSMB5,ANAPC1,PSMB7,UBE2D1,ANAPC5,PTTG1,PSMD8,PSMB3,CDC20,CDC23,PSMB8,PSMD14,PSME1,PSMC4,PSMB9
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	0.828701876843311	-0.187894806325421	73	62	0.00686296214301528	9034	10285	51529,7316,7979,23198,5713,996,5710,143471,122706,9184,5684,5700,10197,9491,7311,5699,5692,5701,5718,4085,5707,6233,25906,9861,5694,5711,5708,5682,5715,5706,5717,11065,701,7324,119504,5687,5719,5685,7314,10393,983,64682,5693,29945,5686,5702,51434,5690,5691,890,991,8697,5714,51433,5695,7321,5698,5704,8900,5720,5696,10213	ANAPC11,UBC,SEM1,PSME4,PSMD7,CDC27,PSMD4,PSMA8,PSMB11,BUB3,PSMA3,PSMC1,PSME3,PSMF1,UBA52,PSMB10,PSMB4,PSMC2,PSMD12,MAD2L1,PSMD1,RPS27A,ANAPC15,PSMD6,PSMB6,PSMD5,PSMD2,PSMA1,PSMD9,PSMC6,PSMD11,UBE2C,BUB1B,UBE2E1,ANAPC16,PSMA6,PSMD13,PSMA4,UBB,ANAPC10,CDK1,ANAPC1,PSMB5,ANAPC4,PSMA5,PSMC3,ANAPC7,PSMB2,PSMB3,CCNA2,CDC20,CDC23,PSMD8,ANAPC5,PSMB7,UBE2D1,PSMB9,PSMC4,CCNA1,PSME1,PSMB8,PSMD14
R-HSA-2022928	HS-GAG biosynthesis	0.832379399286635	-0.18346693334335	31	26	0.00287801638255479	9034	10285	9955,9957,2262,26035,64579,266722,9951,2132,3340,6385,9956,9348,9653,9672,3339,6382,375790,11046,10082,222537,64711,6383,9394,2131,2817,9953	HS3ST3A1,HS3ST1,GPC5,GLCE,NDST4,HS6ST3,HS3ST4,EXT2,NDST1,SDC4,HS3ST2,NDST3,HS2ST1,SDC3,HSPG2,SDC1,AGRN,SLC35D2,GPC6,HS3ST5,HS3ST6,SDC2,HS6ST1,EXT1,GPC1,HS3ST3B1
R-HSA-180786	Extension of Telomeres	0.832379399286635	-0.18346693334335	31	26	0.00287801638255479	9034	10285	57804,5982,1763,54107,7015,5557,5983,55135,10856,55651,5558,6119,56655,5424,6117,23649,5984,5985,8607,6118,10714,3978,5427,5981,2237,5111	POLD4,RFC2,DNA2,POLE3,TERT,PRIM1,RFC3,WRAP53,RUVBL2,NHP2,PRIM2,RPA3,POLE4,POLD1,RPA1,POLA2,RFC4,RFC5,RUVBL1,RPA2,POLD3,LIG1,POLE2,RFC1,FEN1,PCNA
R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	0.832547816587505	-0.183264621434651	18	15	0.00166039406685853	9034	10285	677,167227,11340,207,7529,9261,23016,118460,23404,5393,54464,56915,51010,22894,55802	ZFP36L1,DCP2,EXOSC8,AKT1,YWHAB,MAPKAPK2,EXOSC7,EXOSC6,EXOSC2,EXOSC9,XRN1,EXOSC5,EXOSC3,DIS3,DCP1A
R-HSA-73780	RNA Polymerase III Chain Elongation	0.832547816587505	-0.183264621434651	18	15	0.00166039406685853	9034	10285	661,9533,10622,51082,5434,5440,55718,27297,171568,84265,55703,5441,10623,51728,11128	POLR3D,POLR1C,POLR3G,POLR1D,POLR2E,POLR2K,POLR3E,CRCP,POLR3H,POLR3GL,POLR3B,POLR2L,POLR3C,POLR3K,POLR3A
R-HSA-2022377	Metabolism of Angiotensinogen to Angiotensins	0.832547816587505	-0.183264621434651	18	15	0.00166039406685853	9034	10285	1509,1522,1215,1636,183,1361,5972,4311,84909,2999,1359,1511,290,2028,1360	CTSD,CTSZ,CMA1,ACE,AGT,CPB2,REN,MME,AOPEP,GZMH,CPA3,CTSG,ANPEP,ENPEP,CPB1
R-HSA-450513	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	0.832547816587505	-0.183264621434651	18	15	0.00166039406685853	9034	10285	54464,56915,3842,5393,51010,7538,55802,22894,11340,167227,7529,118460,9261,23016,23404	XRN1,EXOSC5,TNPO1,EXOSC9,EXOSC3,ZFP36,DCP1A,DIS3,EXOSC8,DCP2,YWHAB,EXOSC6,MAPKAPK2,EXOSC7,EXOSC2
R-HSA-351202	Metabolism of polyamines	0.83305257264619	-0.182658526386403	87	74	0.0081912773965021	9034	10285	6538,6723,5695,5691,4507,5714,113451,548596,10166,5720,1373,10213,5696,384,5698,1159,79814,1152,5704,5719,5685,5687,2593,5702,55256,5686,58478,5690,5693,5707,83884,6534,435,1728,5718,5701,5717,51686,5706,5715,5682,383,2805,5694,54498,9861,5708,5711,2628,143471,5710,7979,6539,1160,262,4953,23198,51582,5713,4947,9491,5700,10197,1158,57407,5692,5699,445,51074,84245,5684,4946,122706,162417	SLC6A11,SRM,PSMB7,PSMB3,MTAP,PSMD8,AZIN2,CKMT1A,SLC25A15,PSME1,CPS1,PSMD14,PSMB8,ARG2,PSMB9,CKMT1B,AGMAT,CKB,PSMC4,PSMD13,PSMA4,PSMA6,GAMT,PSMC3,ADI1,PSMA5,ENOPH1,PSMB2,PSMB5,PSMD1,SLC25A2,SLC6A7,ASL,NQO1,PSMD12,PSMC2,PSMD11,OAZ3,PSMC6,PSMD9,PSMA1,ARG1,GOT1,PSMB6,SMOX,PSMD6,PSMD2,PSMD5,GATM,PSMA8,PSMD4,SEM1,SLC6A12,CKMT2,AMD1,ODC1,PSME4,AZIN1,PSMD7,OAZ2,PSMF1,PSMC1,PSME3,CKM,NMRAL1,PSMB4,PSMB10,ASS1,APIP,MRI1,PSMA3,OAZ1,PSMB11,NAGS
R-HSA-69278	Cell Cycle, Mitotic	0.833421248578612	-0.182216064064174	514	445	0.0492583573168032	9034	10285	8370,9631,23594,126961,4149,1062,22995,80152,9491,22919,23291,9493,8968,25936,1454,5701,10776,8358,902,5682,8339,10133,79682,22974,56655,23047,8945,54892,54801,84296,84930,8815,8359,5685,8290,10000,51659,5594,5686,221496,8454,80776,10403,80184,64900,10926,4660,55835,64151,23225,2237,7321,286826,128312,140609,7443,23279,23511,94239,121441,8350,129401,9978,64105,7298,896,83540,4085,151246,5111,8357,5706,5566,5885,8615,995,157570,81930,79172,8379,55706,23595,5515,7314,1063,10121,91754,22994,993,9212,5516,5702,9126,51434,723790,8364,401541,7840,3021,5714,891,151648,10112,387893,23332,4331,5424,8341,4218,143471,5347,5710,3796,5520,8367,1459,3018,7979,23198,7157,4928,25836,996,81565,984,5692,122706,1029,1763,8334,7029,9088,51512,80321,5427,5108,4659,55746,8343,5717,5928,5527,1031,8360,10762,4172,9861,55055,80254,9662,699,5933,4175,332,113130,9134,23310,3320,5500,8317,5695,10733,1875,84515,8655,991,8354,9232,64785,84643,1028,84962,5696,6500,81929,57405,55388,51529,55722,9700,95681,9735,8345,4927,23122,8368,4605,3017,8346,22822,5718,5528,4998,81876,8970,3161,7084,79019,3619,2801,132660,348995,9688,4999,5719,100616122,5529,25909,4171,4001,1032,11004,23194,6241,57804,5693,11190,79023,9918,23175,10426,1871,5691,7514,8697,1027,63943,7027,9663,80028,5984,1457,5001,207,79959,4173,8318,9183,8365,23244,7316,26271,5578,255919,8348,10197,5557,7444,121504,8366,9883,1859,7531,8021,54107,5526,54820,3013,10051,64946,23397,57122,653604,51053,5525,5715,79441,11065,1719,7324,6502,10806,1781,27175,81620,10274,10783,5000,1453,10382,9818,1058,100302237,10592,5690,11258,1870,5579,1021,79648,26003,890,4609,10714,8900,5903,8362,4000,5704,8349,3326,4926,994,8361,1030,5713,2029,7175,5558,8556,8347,1639,5577,2033,11130,5595,7311,91750,5699,3015,85378,1022,5684,79902,6249,595,10142,5925,79866,4957,7153,93323,8363,23421,5711,8340,9793,54908,9702,119504,5905,10393,5501,10540,147841,7532,3012,11064,23165,100101267,10213,55755,5698,220134,1026,3065,8086,7277,55839,1778,8353,9814,203068,55920,894,1017,5934,23383,5861,5985,9133,6117,5519,23636,23649,64689,701,115106,5708,8548,11097,5687,7465,57551,6790,84131,1060,4751,8344,57082,6418,64682,983,3020,5982,10726,5518,5753,9972,11243,6232,55957,9837,23354,898,5700,5983,79980,114791,5048,4174,23063,9184,5707,22981,5981,6233,25906,6118,1869,7112,8355,6396,1874,5694,22897,51343,23592,8335,6119,8352,7846,54930,208,55125,728642,5862,29945,3978,55766,53371,51433,1019,5720,990	H4C14,NUP155,ORC6,H3C14,MAX,CENPE,CEP152,CENPT,PSMF1,MAPRE1,FBXW11,KIF23,H3C7,NSL1,CSNK1E,PSMC2,ARPP19,H3C2,CCNH,PSMA1,H2BC8,OPTN,CENPU,TPX2,POLE4,PDS5B,BTRC,NCAPG2,HAUS6,GINS4,MASTL,BANF1,H4C1,PSMA4,H3-4,AKT3,GINS2,MAPK1,PSMA5,LEMD2,CUL1,B9D2,NDC80,CEP290,LPIN3,DBF4,PPP1R12B,CENPJ,NCAPG,NUP210,FEN1,UBE2D1,LIN9,H2BC26,NEK7,VRK1,NUP160,NUP188,H2AZ2,NEDD1,H3C1,NUP35,RBX1,CENPK,TYMS,CCND3,NUF2,MAD2L1,SGO2,PCNA,H3C10,PSMC6,PRKACA,RAD21,USO1,CDC25C,ESCO2,KIF18A,CENPO,MAD1L1,NDC1,ORC3,PPP2CA,UBB,CENPF,ACTR1A,NEK9,CEP131,CDC25A,AURKB,PPP2CB,PSMC3,SMC3,ANAPC7,H2AC19,H4C3,CENPP,ALMS1,H3-3B,PSMD8,CCNB1,SGO1,KIF20A,KMT5A,CLASP1,MNAT1,POLD1,H2BC15,RAB8A,PSMA8,PLK1,PSMD4,KIF2A,PPP2R2A,H4C5,CSNK2A2,H2BC3,SEM1,PSME4,TP53,NUP98,NIPBL,CDC27,NDEL1,CDK11B,PSMB4,PSMB11,CDKN2A,DNA2,H2AC6,TFDP2,PKMYT1,GTSE1,CEP70,POLE2,PCM1,PPP1R12A,NUP133,H2BC7,PSMD11,RBBP4,PPP2R5C,CDKN2C,H4C4,NUP50,MCM3,PSMD6,ZWILCH,CEP63,CEP135,BUB1,RBL1,MCM6,BIRC5,CDCA5,CCNE2,NCAPD3,HSP90AA1,PPP1CB,CDC7,PSMB7,PLK4,E2F5,MCM8,DYNLL1,CDC20,H3C11,PTTG1,GINS3,KIF2B,CDKN1C,AJUBA,PSMB8,SKP1,SEH1L,SPC25,MCM10,ANAPC11,CEP72,ESPL1,CEP41,KNTC1,H2BC9,NUP88,CLASP2,H4C13,MYBL2,H2BC5,H2BC10,PHLDA1,PSMD12,PPP2R5D,ORC1,RAB1B,H2BC11,HMMR,TK2,CENPM,INCENP,GOLGA2,LIN54,NUP43,NUP93,ORC2,PSMD13,MIR4523,PPP2R5E,AHCTF1,MCM2,LMNB1,CDKN2D,KIF2C,FBXL7,RRM2,POLD4,PSMB5,CEP250,NUP37,NCAPD2,LPIN1,TUBGCP3,E2F3,PSMB3,XPO1,CDC23,CDKN1B,FKBPL,TFDP1,LPIN2,FBXL18,RFC4,CSNK2A1,ORC5,AKT1,CEP76,MCM4,CDC45,ZW10,H4C8,PDS5A,UBC,FBXO5,PRKCA,CNEP1R1,H2BC17,PSME3,PRIM1,VRK2,H4C16,H4C2,POM121,DYRK1A,YWHAE,NUP214,POLE3,PPP2R5B,NDE1,H2AC7,SMC4,CENPH,NCAPH,NUP107,H3C13,GMNN,PPP2R5A,PSMD9,HAUS3,UBE2C,DHFR,UBE2E1,SKP2,SDCCAG8,DYNC1I2,TUBG2,CDT1,STAG1,NEK6,ORC4,CSNK1D,TUBB4A,NUP58,CENPA,MIR1281,SMC2,PSMB2,DCTN3,E2F2,PRKCB,CDK6,MCPH1,GORASP2,CCNA2,MYC,POLD3,CCNA1,RANBP2,H4C12,LMNA,PSMC4,H2BC21,HSP90AB1,NUMA1,CDC25B,H4C6,CDKN2B,PSMD7,ENSA,TPR,PRIM2,CDC14A,H2BC4,DCTN1,PRKAR2B,EP300,ZWINT,MAPK3,UBA52,LIN52,PSMB10,H2AZ1,TUBGCP6,CDK7,PSMA3,NUP85,CLIP1,CCND1,AKAP9,RB1,BORA,ODF2,TOP2A,HAUS8,H4C11,ITGB3BP,PSMD5,H2BC13,CKAP5,SPDL1,CEP57,ANAPC16,RANGAP1,ANAPC10,PPP1CC,DCTN2,SPC24,YWHAG,H2AC8,CNTRL,NUP205,POM121C,PSMD14,CDK5RAP2,PSMB9,SKA1,CDKN1A,HDAC1,AAAS,TUBA4A,CENPN,DYNC1H1,H3C6,SFI1,TUBB,RCC2,CCND2,CDK2,RBL2,MAU2,RAB1A,RFC5,CCNB2,RPA1,PPP2R1B,NUP62,POLA2,GORASP1,BUB1B,HAUS1,PSMD2,BLZF1,NUP42,PSMA6,WEE1,TAOK1,AURKA,CEP78,CENPC,NEK2,H2BC6,KNL1,SET,ANAPC1,CDK1,H3-3A,RFC2,NUDC,PPP2R1A,PTK6,NUP153,PMF1,RPS27,LIN37,GINS1,HAUS5,CCNE1,PSMC1,RFC3,DSN1,TUBGCP5,PAFAH1B1,MCM5,WAPL,BUB3,PSMD1,NINL,RFC1,RPS27A,ANAPC15,RPA2,E2F1,TMPO,H3C8,SEC13,E2F4,PSMB6,CEP164,FZR1,LEMD3,H2AC4,RPA3,H3C3,TUBA1A,HAUS4,AKT2,CEP192,CDK11A,RAB2A,ANAPC4,LIG1,H2AJ,NUP54,ANAPC5,CDK4,PSME1,CDC6
R-HSA-162906	HIV Infection	0.83356153566993	-0.182047751478136	236	203	0.0224706663714855	9034	10285	2961,5702,6882,6829,9150,3981,55706,7314,5905,23165,100101267,10213,83860,7520,5698,4331,138474,3932,2963,9844,2957,51534,5714,8731,91782,5699,7311,5684,1022,25978,5439,6875,51510,1175,9978,129401,7175,5713,5706,7469,130340,11168,5902,5711,9397,79902,55690,7518,1174,2071,5686,5690,6874,2965,5901,5685,8815,8907,4836,5430,100506888,2547,163,9818,5903,2068,2958,23279,22916,23511,5704,6884,23225,4869,2237,100302168,6924,4686,8732,10197,9491,8021,9883,2959,10053,7936,3837,5478,6883,162699,8065,5045,9631,164,7316,7251,6923,5440,1173,5682,5715,8812,6749,6873,6921,8945,6827,51652,1234,57122,9525,902,2962,5701,6881,137492,2534,5693,79023,9688,5719,2968,51497,3105,5433,926,5720,55048,5062,5431,3978,53371,161,7514,5691,5700,6880,404672,1104,4927,100126332,128866,7852,60489,6877,79643,81929,92421,5441,375,5694,348995,5707,23327,6233,5434,5718,100302242,11198,27183,2967,5687,11097,6917,1794,919,567,5696,940,6879,3159,160,79720,6500,9972,5695,8178,10015,5879,2960,291,5692,162,51606,122706,5710,143471,5432,8086,51224,920,7979,905,3836,4928,23198,904,5717,23636,10762,9861,5708,55746	GTF2E2,PSMC3,TAF11,SUPT5H,CTDP1,LIG4,NDC1,UBB,RANGAP1,NUP205,POM121C,PSMD14,TAF3,XRCC5,PSMB9,MNAT1,TAF1L,LCK,GTF2F2,ELMO1,GTF2A1,VTA1,PSMD8,RNMT,CHMP7,PSMB10,UBA52,PSMA3,CDK7,CHMP2B,POLR2J,TAF4B,CHMP5,AP2S1,RBX1,NUP35,TPR,PSMD7,PSMC6,NELFA,AP1S3,PSIP1,RANBP1,PSMD5,NMT2,NUP85,PACS1,XRCC4,AP1S1,ERCC3,PSMA5,PSMB2,TAF4,GTF2H1,RAN,PSMA4,BANF1,AP1M1,NMT1,POLR2A,ELOA3DP,XRCC6,AP2B1,NUP58,RANBP2,ERCC2,GTF2A2,NUP160,NCBP2,NUP188,PSMC4,TAF13,NUP210,NPM1,FEN1,MIR1257,ELOA,NCBP1,RNGTT,PSME3,PSMF1,NUP214,POM121,GTF2B,AP1M2,NELFE,KPNB1,PPIA,TAF12,ELOA3P,CUL5,FURIN,NUP155,AP1G1,UBC,TSG101,ELOB,POLR2K,AP2M1,PSMA1,PSMD9,CCNK,SSRP1,TAF2,ELOC,BTRC,SUPT4H1,CHMP3,CCR5,NUP107,VPS4B,CCNH,GTF2F1,PSMC2,TAF10,VPS37A,FYN,PSMB5,NUP37,NUP93,PSMD13,GTF2H4,NELFCD,HLA-A,POLR2D,CD8B,PSME1,VPS37C,PAK2,POLR2B,LIG1,NUP54,AP2A2,XPO1,PSMB3,PSMC1,TAF9,GTF2H5,RCC1,NUP88,MIR943,CHMP4B,CXCR4,APOBEC3G,TAF5,CHMP6,SEH1L,CHMP4C,POLR2L,ARF1,PSMB6,NUP43,PSMD1,NEDD4L,RPS27A,POLR2E,PSMD12,MIR1236,SUPT16H,VPS4A,GTF2H3,PSMA6,NUP42,TCEA1,DOCK2,CD247,B2M,PSMB8,CD28,TAF7,HMGA1,AP2A1,VPS37B,SKP1,NUP153,PSMB7,ELL,PDCD6IP,RAC1,GTF2E1,SLC25A4,PSMB4,AP1B1,ATP6V1H,PSMB11,PSMD4,PSMA8,POLR2C,AAAS,ELOA2,CD4,SEM1,CCNT2,KPNA1,NUP98,PSME4,CCNT1,PSMD11,NUP62,NUP50,PSMD6,PSMD2,NUP133
R-HSA-2467813	Separation of Sister Chromatids	0.834098418711243	-0.181403875538738	168	144	0.0159397830418419	9034	10285	25906,6249,6233,5707,151246,4085,79902,5528,5718,3619,6396,79019,5706,5711,23421,348995,81930,5694,5885,81929,57405,5713,9735,9700,51529,79980,5699,7311,64105,23122,5700,11130,5684,9184,83540,23063,5048,147841,5714,51433,8697,5691,7514,10213,5720,23332,9183,220134,5698,151648,54908,7314,1063,25909,9793,5719,5515,5529,100616122,79172,8379,9212,5905,119504,9126,51434,5702,11004,5516,29945,401541,79023,5501,5693,10393,64946,54820,5526,5701,55746,57122,25936,7324,701,11065,5527,5717,5519,5715,5525,5682,5708,699,55055,23047,79682,9861,5347,143471,3796,5710,80152,81565,996,23198,4928,1062,7979,7316,23244,55839,5692,9491,10197,55920,122706,22919,7321,5695,11243,9232,6232,991,5696,5903,84643,5704,23279,332,113130,5685,10274,5687,1060,57551,5690,57082,80776,10403,5686,1058,10726,5518,64682	ANAPC15,CLIP1,RPS27A,PSMD1,SGO2,MAD2L1,NUP85,PPP2R5D,PSMD12,INCENP,SEC13,CENPM,PSMC6,PSMD5,ITGB3BP,NUP43,KIF18A,PSMB6,RAD21,SEH1L,SPC25,PSMD7,KNTC1,ESPL1,ANAPC11,DSN1,PSMB10,UBA52,CENPK,CLASP2,PSMC1,ZWINT,PSMA3,BUB3,NUF2,WAPL,PAFAH1B1,SPC24,PSMD8,ANAPC5,CDC23,PSMB3,XPO1,PSMD14,PSME1,CLASP1,ZW10,SKA1,PSMB9,SGO1,SPDL1,UBB,CENPF,AHCTF1,CKAP5,PSMD13,PPP2CA,PPP2R5E,MIR4523,CENPO,MAD1L1,AURKB,RANGAP1,ANAPC16,SMC3,ANAPC7,PSMC3,KIF2C,PPP2CB,ANAPC4,CENPP,NUP37,PPP1CC,PSMB5,ANAPC10,CENPH,NDE1,PPP2R5B,PSMC2,NUP133,NUP107,NSL1,UBE2E1,BUB1B,UBE2C,PPP2R5C,PSMD11,PPP2R1B,PSMD9,PPP2R5A,PSMA1,PSMD2,BUB1,ZWILCH,PDS5B,CENPU,PSMD6,PLK1,PSMA8,KIF2A,PSMD4,CENPT,NDEL1,CDC27,PSME4,NUP98,CENPE,SEM1,UBC,PDS5A,CENPN,PSMB4,PSMF1,PSME3,RCC2,PSMB11,MAPRE1,UBE2D1,PSMB7,PMF1,PTTG1,RPS27,CDC20,PSMB8,RANBP2,KIF2B,PSMC4,NUP160,BIRC5,CDCA5,PSMA4,STAG1,PSMA6,CENPC,TAOK1,PSMB2,KNL1,B9D2,NDC80,PSMA5,CENPA,NUDC,PPP2R1A,ANAPC1
R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer	0.838907798549873	-0.175654473011608	58	49	0.00542395395173788	9034	10285	51107,182,54567,3066,55294,1387,4609,3065,6500,7314,84441,102,26508,9148,51564,142678,9734,8454,100302237,23385,22938,9612,6233,388585,54492,9611,3516,8841,9794,8850,10014,6868,79885,83464,1024,79718,55534,23493,5664,9759,9978,7316,892,7311,3280,2033,3714,23462,83933	APH1A,JAG1,DLL4,HDAC2,FBXW7,CREBBP,MYC,HDAC1,SKP1,UBB,MAML2,ADAM10,HEYL,NEURL1,HDAC7,MIB2,HDAC9,CUL1,MIR1281,NCSTN,SNW1,NCOR2,RPS27A,HES5,NEURL1B,NCOR1,RBPJ,HDAC3,MAML1,KAT2B,HDAC5,ADAM17,HDAC11,APH1B,CDK8,TBL1XR1,MAML3,HEY2,PSEN2,HDAC4,RBX1,UBC,CCNC,UBA52,HES1,EP300,JAG2,HEY1,HDAC10
R-HSA-2644603	Signaling by NOTCH1 in Cancer	0.838907798549873	-0.175654473011608	58	49	0.00542395395173788	9034	10285	8850,9794,8841,3516,54492,9611,388585,6233,79885,6868,10014,1024,83464,23493,55534,79718,892,7316,9759,9978,5664,2033,3280,7311,83933,23462,3714,182,51107,4609,55294,1387,3066,54567,6500,3065,51564,102,26508,9148,7314,84441,142678,100302237,8454,9734,9612,23385,22938	KAT2B,MAML1,HDAC3,RBPJ,NEURL1B,NCOR1,HES5,RPS27A,HDAC11,ADAM17,HDAC5,CDK8,APH1B,HEY2,MAML3,TBL1XR1,CCNC,UBC,HDAC4,RBX1,PSEN2,EP300,HES1,UBA52,HDAC10,HEY1,JAG2,JAG1,APH1A,MYC,FBXW7,CREBBP,HDAC2,DLL4,SKP1,HDAC1,HDAC7,ADAM10,HEYL,NEURL1,UBB,MAML2,MIB2,MIR1281,CUL1,HDAC9,NCOR2,NCSTN,SNW1
R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	0.838907798549873	-0.175654473011608	58	49	0.00542395395173788	9034	10285	83464,1024,79885,10014,6868,3516,8841,9794,8850,388585,6233,9611,54492,83933,3714,23462,2033,7311,3280,7316,892,5664,9978,9759,79718,55534,23493,6500,3065,4609,54567,3066,55294,1387,182,51107,9612,22938,23385,9734,100302237,8454,142678,84441,7314,9148,102,26508,51564	APH1B,CDK8,HDAC11,HDAC5,ADAM17,RBPJ,HDAC3,MAML1,KAT2B,HES5,RPS27A,NCOR1,NEURL1B,HDAC10,JAG2,HEY1,EP300,UBA52,HES1,UBC,CCNC,PSEN2,RBX1,HDAC4,TBL1XR1,MAML3,HEY2,SKP1,HDAC1,MYC,DLL4,HDAC2,FBXW7,CREBBP,JAG1,APH1A,NCOR2,SNW1,NCSTN,HDAC9,MIR1281,CUL1,MIB2,MAML2,UBB,NEURL1,ADAM10,HEYL,HDAC7
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	0.838907798549873	-0.175654473011608	58	49	0.00542395395173788	9034	10285	83464,1024,3516,8841,9794,8850,6233,388585,9611,54492,79885,10014,6868,2033,7311,3280,83933,3714,23462,79718,55534,23493,892,7316,5664,9978,9759,6500,3065,182,51107,4609,54567,3066,1387,55294,9734,100302237,8454,9612,22938,23385,84441,7314,9148,102,26508,51564,142678	APH1B,CDK8,RBPJ,HDAC3,MAML1,KAT2B,RPS27A,HES5,NCOR1,NEURL1B,HDAC11,HDAC5,ADAM17,EP300,UBA52,HES1,HDAC10,JAG2,HEY1,TBL1XR1,MAML3,HEY2,CCNC,UBC,PSEN2,RBX1,HDAC4,SKP1,HDAC1,JAG1,APH1A,MYC,DLL4,HDAC2,CREBBP,FBXW7,HDAC9,MIR1281,CUL1,NCOR2,SNW1,NCSTN,MAML2,UBB,NEURL1,ADAM10,HEYL,HDAC7,MIB2
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	0.838907798549873	-0.175654473011608	58	49	0.00542395395173788	9034	10285	54567,3066,55294,1387,4609,51107,182,3065,6500,142678,7314,84441,102,9148,26508,51564,23385,22938,9612,9734,8454,100302237,10014,6868,79885,388585,6233,54492,9611,3516,8841,9794,8850,83464,1024,5664,9978,9759,7316,892,79718,55534,23493,3714,23462,83933,7311,3280,2033	DLL4,HDAC2,FBXW7,CREBBP,MYC,APH1A,JAG1,HDAC1,SKP1,MIB2,UBB,MAML2,ADAM10,NEURL1,HEYL,HDAC7,NCSTN,SNW1,NCOR2,HDAC9,CUL1,MIR1281,HDAC5,ADAM17,HDAC11,HES5,RPS27A,NEURL1B,NCOR1,RBPJ,HDAC3,MAML1,KAT2B,APH1B,CDK8,PSEN2,RBX1,HDAC4,UBC,CCNC,TBL1XR1,MAML3,HEY2,JAG2,HEY1,HDAC10,UBA52,HES1,EP300
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	0.839320230601919	-0.175162964047171	65	55	0.00608811157848129	9034	10285	5982,57804,2965,1642,2967,100302237,2071,51426,5433,5430,6119,2968,7314,6917,57654,5431,4331,5424,91603,2068,5984,3980,10714,3978,57461,54107,1022,2033,404672,7311,5983,7316,9978,5440,8451,10450,5439,5432,2074,3150,56655,9716,5441,6117,1161,7515,7874,5985,902,5434,6118,5427,5111,6233,5981	RFC2,POLD4,GTF2H1,DDB1,GTF2H3,MIR1281,ERCC3,POLK,POLR2D,POLR2A,RPA3,GTF2H4,UBB,TCEA1,UVSSA,POLR2B,MNAT1,POLD1,ZNF830,ERCC2,RFC4,LIG3,POLD3,LIG1,ISY1,POLE3,CDK7,EP300,GTF2H5,UBA52,RFC3,UBC,RBX1,POLR2K,CUL4A,PPIE,POLR2J,POLR2C,ERCC6,HMGN1,POLE4,AQR,POLR2L,RPA1,ERCC8,XRCC1,USP7,RFC5,CCNH,POLR2E,RPA2,POLE2,PCNA,RPS27A,RFC1
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	0.839325856350964	-0.175156261325151	51	43	0.00475979632499447	9034	10285	10213,5696,5715,5720,5682,5717,5706,5711,5704,5708,5062,5694,9861,5698,5695,6233,5707,5701,5714,5718,5691,7311,5692,5699,5690,5686,5702,9491,10197,5700,122706,5684,5693,7314,5687,143471,5710,5685,5719,5713,23198,7316,7979	PSMD14,PSMB8,PSMD9,PSME1,PSMA1,PSMD11,PSMC6,PSMD5,PSMC4,PSMD2,PAK2,PSMB6,PSMD6,PSMB9,PSMB7,RPS27A,PSMD1,PSMC2,PSMD8,PSMD12,PSMB3,UBA52,PSMB4,PSMB10,PSMB2,PSMA5,PSMC3,PSMF1,PSME3,PSMC1,PSMB11,PSMA3,PSMB5,UBB,PSMA6,PSMA8,PSMD4,PSMA4,PSMD13,PSMD7,PSME4,UBC,SEM1
R-HSA-1236978	Cross-presentation of soluble exogenous antigens (endosomes)	0.839325856350964	-0.175156261325151	51	43	0.00475979632499447	9034	10285	5708,5704,5711,5698,9861,5694,5696,10213,2210,5706,5717,5682,5715,5720,5718,5701,5714,5691,2209,5695,9902,5707,5684,122706,50489,5693,5690,5699,5692,5700,10197,5702,9491,5686,23198,5713,7979,4360,5710,5719,5685,143471,5687	PSMD2,PSMC4,PSMD5,PSMB9,PSMD6,PSMB6,PSMB8,PSMD14,FCGR1BP,PSMC6,PSMD11,PSMA1,PSMD9,PSME1,PSMD12,PSMC2,PSMD8,PSMB3,FCGR1A,PSMB7,MRC2,PSMD1,PSMA3,PSMB11,CD207,PSMB5,PSMB2,PSMB10,PSMB4,PSMC1,PSME3,PSMC3,PSMF1,PSMA5,PSME4,PSMD7,SEM1,MRC1,PSMD4,PSMD13,PSMA4,PSMA8,PSMA6
R-HSA-189483	Heme degradation	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	3163,54658,54657,644,3162	HMOX2,UGT1A1,UGT1A4,BLVRA,HMOX1
R-HSA-390247	Beta-oxidation of very long chain fatty acids	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	3295,1384,10005,30,51	HSD17B4,CRAT,ACOT8,ACAA1,ACOX1
R-HSA-5624138	Trafficking of myristoylated proteins to the cilium	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	84747,403,192668,100616329,27031	UNC119B,ARL3,CYS1,MIR4700,NPHP3
R-HSA-5690714	CD22 mediated BCR regulation	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	933,4067,5777,974,973	CD22,LYN,PTPN6,CD79B,CD79A
R-HSA-3323169	Defects in biotin (Btn) metabolism	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	56922,31,5091,5095,5096	MCCC1,ACACA,PC,PCCA,PCCB
R-HSA-211916	Vitamins	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	1594,1591,120227,56603,1592	CYP27B1,CYP24A1,CYP2R1,CYP26B1,CYP26A1
R-HSA-5368598	Negative regulation of TCF-dependent signaling by DVL-interacting proteins	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	80319,1857,1856,1855,440193	CXXC4,DVL3,DVL2,DVL1,CCDC88C
R-HSA-205025	NADE modulates death signalling	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	836,4803,4804,7531,835	CASP3,NGF,NGFR,YWHAE,CASP2
R-HSA-166662	Lectin pathway of complement activation	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	4153,5648,10747,2219,2220	MBL2,MASP1,MASP2,FCN1,FCN2
R-HSA-3371599	Defective HLCS causes multiple carboxylase deficiency	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	56922,31,5091,5096,5095	MCCC1,ACACA,PC,PCCB,PCCA
R-HSA-6787639	GDP-fucose biosynthesis	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	2762,197258,55343,8790,7264	GMDS,FCSK,SLC35C1,FPGT,GFUS
R-HSA-428808	Na+-dependent glucose transporters	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	200010,6523,6527,6526,91749	SLC5A9,SLC5A1,SLC5A4,SLC5A3,MFSD4B
R-HSA-1482798	Acyl chain remodeling of CL	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	253558,8398,3030,3032,5321	LCLAT1,PLA2G6,HADHA,HADHB,PLA2G4A
R-HSA-1566977	Fibronectin matrix formation	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	2335,634,1088,3688,4680	FN1,CEACAM1,CEACAM8,ITGB1,CEACAM6
R-HSA-388479	Vasopressin-like receptors	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	5021,5020,551,552,553	OXTR,OXT,AVP,AVPR1A,AVPR1B
R-HSA-947581	Molybdenum cofactor biosynthesis	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	55034,27304,4337,10243,4338	MOCOS,MOCS3,MOCS1,GPHN,MOCS2
R-HSA-6782861	Synthesis of wybutosine at G37 of tRNA(Phe)	0.840875200128529	-0.173312024636064	6	5	0.000553464688952845	9034	10285	129450,57570,55253,127253,55039	TYW5,TRMT5,TYW1,TYW3,TRMT12
R-HSA-70895	Branched-chain amino acid catabolism	0.840912825109798	-0.173267280612785	24	20	0.00221385875581138	9034	10285	1629,586,223,26275,36,6470,549,10295,587,27034,152926,593,38,4329,3712,8424,56922,11112,1738,594	DBT,BCAT1,ALDH9A1,HIBCH,ACADSB,SHMT1,AUH,BCKDK,BCAT2,ACAD8,PPM1K,BCKDHA,ACAT1,ALDH6A1,IVD,BBOX1,MCCC1,HIBADH,DLD,BCKDHB
R-HSA-191273	Cholesterol biosynthesis	0.840912825109798	-0.173267280612785	24	20	0.00221385875581138	9034	10285	1717,1595,2222,64801,6307,3422,9453,39,4597,3157,2224,6309,6713,10654,7108,51478,4598,3930,1718,3156	DHCR7,CYP51A1,FDFT1,ARV1,MSMO1,IDI1,GGPS1,ACAT2,MVD,HMGCS1,FDPS,SC5D,SQLE,PMVK,TM7SF2,HSD17B7,MVK,LBR,DHCR24,HMGCR
R-HSA-1483206	Glycerophospholipid biosynthesis	0.849024256817837	-0.16366752203319	129	110	0.0121762231569626	9034	10285	10423,1757,100137049,8895,5319,56894,253558,29958,56910,1459,8443,57605,635,3030,11343,79888,10400,23760,56994,151056,57678,23171,1119,63874,5320,84879,8605,23646,154141,2819,10809,64900,57110,150763,5337,64850,3032,9489,81490,81579,55326,114879,56261,23259,80339,50487,10162,23761,122618,5322,64600,114884,137964,11145,5321,8904,83394,43,114882,114971,126969,27132,51205,22925,84803,9600,204962,10390,55349,79887,5130,57153,26279,54947,50640,9926,8398,255189,57104,283748,5833,201164,5338,55500,54675,56895,23446,162466,1040,123745,501,30814,117245,58488,80821,1457,9791,9663,51365,1103,129642,84649,590,9362,23175,79143,55224,248,8760,80736	CDIPT,SARDH,PLA2G4B,CPNE3,PLA2G1B,AGPAT3,LCLAT1,DMGDH,STARD7,CSNK2A2,GNPAT,PITPNM2,BHMT,HADHA,MGLL,LPCAT1,PEMT,PITPNB,CHPT1,PLB1,GPAM,GPD1L,CHKA,ABHD4,PLA2G2A,MFSD2A,PLA2G4C,PLD3,MBOAT1,GPD1,STARD10,LPIN3,PLAAT1,GPAT2,PLD1,ETNPPL,HADHB,PGS1,PTDSS2,PLA2G12A,AGPAT5,OSBPL5,GPCPD1,DDHD2,PNPLA3,PLA2G3,LPCAT3,PISD,PLD4,PLA2G5,PLA2G2F,OSBPL10,GPAT4,PLAAT3,PLA2G4A,CPNE1,PITPNM3,ACHE,OSBPL8,PTPMT1,SLC44A3,CPNE7,ACP6,PLA2R1,GPAT3,PITPNM1,SLC44A5,CEPT1,CHDH,PLBD1,PCYT1A,SLC44A2,PLA2G2D,LPCAT2,PNPLA8,LPGAT1,PLA2G6,PLA2G4F,PNPLA2,PLA2G4D,PCYT2,PLD6,PLD2,ETNK1,CRLS1,AGPAT4,SLC44A1,PHOSPHO1,CDS1,PLA2G4E,ALDH7A1,PLA2G2E,PLAAT5,PCTP,DDHD1,CSNK2A1,PTDSS1,LPIN2,PLA1A,CHAT,MBOAT2,DGAT2,BCHE,CPNE6,LPIN1,MBOAT7,ETNK2,ALPI,CDS2,SLC44A4
R-HSA-5669034	TNFs bind their physiological receptors	0.850411671190691	-0.162034727694518	30	25	0.00276732344476422	9034	10285	7292,9966,7293,356,23495,128178,8740,8718,4982,608,10673,970,10913,8784,8600,8741,8995,7133,943,3604,4049,944,939,7132,8744	TNFSF4,TNFSF15,TNFRSF4,FASLG,TNFRSF13B,EDARADD,TNFSF14,TNFRSF25,TNFRSF11B,TNFRSF17,TNFSF13B,CD70,EDAR,TNFRSF18,TNFSF11,TNFSF13,TNFSF18,TNFRSF1B,TNFRSF8,TNFRSF9,LTA,TNFSF8,CD27,TNFRSF1A,TNFSF9
R-HSA-429914	Deadenylation-dependent mRNA decay	0.851525668912099	-0.160725633811625	57	48	0.00531326101394731	9034	10285	219988,25904,196513,22894,9924,55802,4849,23404,1975,1977,9775,26986,80153,23016,57819,25804,51690,85456,29883,9125,51010,27257,27258,1981,9337,11340,167227,10767,11157,10605,1974,55571,246175,255967,57472,118460,9652,5393,56915,4848,1656,54464,5073,23658,28960,23644,4850,23019	PATL1,CNOT10,DCP1B,DIS3,PAN2,DCP1A,CNOT3,EXOSC2,EIF4B,EIF4E,EIF4A3,PABPC1,EDC3,EXOSC7,LSM2,LSM4,LSM7,TNKS1BP1,CNOT7,CNOT9,EXOSC3,LSM1,LSM3,EIF4G1,CNOT8,EXOSC8,DCP2,HBS1L,LSM6,PAIP1,EIF4A2,CNOT11,CNOT6L,PAN3,CNOT6,EXOSC6,SKIC3,EXOSC9,EXOSC5,CNOT2,DDX6,XRN1,PARN,LSM5,DCPS,EDC4,CNOT4,CNOT1
R-HSA-1428517	The citric acid (TCA) cycle and respiratory electron transport	0.852874481801491	-0.159142891436954	158	135	0.0149435466017268	9034	10285	51660,4700,6566,51241,10632,506,50,8802,9377,513,100616403,51079,7352,1337,285521,5467,7384,51103,4706,4722,79944,8050,55471,79133,4711,4707,4705,3029,28976,539,126328,6341,6390,1743,4718,509,10476,5164,4702,514,4726,1327,23539,7381,4725,4719,7350,1738,1350,29796,1345,5163,4720,4191,4698,1340,3945,29078,6392,4714,116228,91942,515,6391,10975,4724,4731,55066,498,5162,4710,3418,9481,4717,4729,4715,682,160287,1431,10131,2739,4967,4708,4716,54704,2271,80219,1329,10128,23530,93058,137872,4709,84987,7385,8803,137682,1737,516,27109,3420,4728,4712,2110,55967,7386,3939,25874,54205,374291,9123,6256,522,1353,518,6389,80224,4696,51300,1351,7351,4723,2108,4704,51295,5166,57546,8801,3948,4697,92483,4695,517,3419,9167	MPC1,NDUFA6,SLC16A1,COX16,ATP5MG,ATP5F1B,ACO2,SUCLG1,COX5A,ATP5F1D,MIR4691,NDUFA13,UCP3,COX6A1,COX18,PPARD,UQCRC1,NDUFAF1,NDUFAB1,NDUFS3,L2HGDH,PDHX,NDUFAF7,NDUFAF5,NDUFB5,NDUFB1,NDUFA10,HAGH,ACAD9,ATP5PO,NDUFA11,SCO1,SDHB,DLST,NDUFC2,ATP5F1C,ATP5PD,PDK2,NDUFA8,ATP5F1E,NDUFS6,COX4I1,SLC16A8,UQCRB,NDUFS5,NDUFS1,UCP1,DLD,COX7C,UQCR10,COX6C,PDK1,NDUFS2,MDH2,NDUFA5,COX6B1,LDHB,NDUFAF4,SDHD,NDUFB8,COX20,NDUFAF2,ATP5PB,SDHC,UQCR11,NDUFS4,NDUFV3,PDPR,ATP5F1A,PDHB,NDUFB4,IDH2,SLC25A27,NDUFC1,NDUFV2,NDUFB9,BSG,LDHAL6A,CS,TRAP1,GLO1,OGDH,NDUFB2,NDUFB10,PDP1,FH,COQ10B,COX5B,LRPPRC,NNT,COQ10A,ADHFE1,NDUFB3,COX14,UQCRC2,SUCLA2,NDUFAF6,DLAT,ATP5MC1,DMAC2L,IDH3B,NDUFS8,NDUFB6,ETFDH,NDUFA12,UQCRFS1,LDHA,MPC2,CYCS,NDUFS7,SLC16A3,RXRA,ATP5PF,COX11,ATP5MC3,SDHA,NUBPL,NDUFA3,TIMMDC1,COX8A,UCP2,NDUFV1,ETFA,NDUFA9,ECSIT,PDK4,PDP2,SUCLG2,LDHC,NDUFA4,LDHAL6B,NDUFA2,ATP5MC2,IDH3A,COX7A2L
R-HSA-2555396	Mitotic Metaphase and Anaphase	0.854902308883754	-0.156768075188882	180	154	0.0170467124197476	9034	10285	1062,7316,26271,7979,23244,55839,80152,81565,996,23198,4928,5347,143471,5520,5710,3796,22919,122706,9491,10197,55920,5692,7444,57122,25936,5701,55746,5526,64946,54820,55055,23047,79682,9861,5708,699,5717,5527,5715,5519,5525,5682,7324,701,11065,1060,57551,8815,5685,10274,5687,113130,332,64682,10726,5518,5686,1058,221496,5690,80776,57082,10403,6232,991,9232,7321,5695,11243,23279,5704,5903,84643,5696,7443,4000,51529,5713,9700,9735,81929,57405,5048,5684,9184,83540,23063,64105,5700,23122,11130,79980,5699,7311,5718,5528,7112,5707,151246,4085,79902,25906,6249,6233,81930,5885,5694,5711,23421,348995,5706,3619,6396,79019,4001,9212,5905,119504,9793,5529,5515,5719,100616122,79172,23592,8379,54908,1063,7314,25909,5693,10393,29945,401541,5501,79023,5702,5516,11004,9126,51434,8697,5691,7514,51433,5714,147841,5698,151648,23332,9183,220134,5720,10213	CENPE,UBC,FBXO5,SEM1,PDS5A,CENPN,CENPT,NDEL1,CDC27,PSME4,NUP98,PLK1,PSMA8,PPP2R2A,PSMD4,KIF2A,MAPRE1,PSMB11,PSMF1,PSME3,RCC2,PSMB4,VRK2,NUP107,NSL1,PSMC2,NUP133,PPP2R5B,CENPH,NDE1,ZWILCH,PDS5B,CENPU,PSMD6,PSMD2,BUB1,PSMD11,PPP2R5C,PSMD9,PPP2R1B,PPP2R5A,PSMA1,UBE2E1,BUB1B,UBE2C,CENPC,TAOK1,BANF1,PSMA4,STAG1,PSMA6,CDCA5,BIRC5,ANAPC1,NUDC,PPP2R1A,PSMA5,CENPA,LEMD2,PSMB2,B9D2,KNL1,NDC80,RPS27,CDC20,PTTG1,UBE2D1,PSMB7,PMF1,NUP160,PSMC4,RANBP2,KIF2B,PSMB8,VRK1,LMNA,ANAPC11,PSMD7,ESPL1,KNTC1,SEH1L,SPC25,PAFAH1B1,PSMA3,BUB3,NUF2,WAPL,CENPK,PSMC1,CLASP2,ZWINT,DSN1,PSMB10,UBA52,PSMD12,PPP2R5D,TMPO,PSMD1,SGO2,MAD2L1,NUP85,ANAPC15,CLIP1,RPS27A,KIF18A,RAD21,PSMB6,PSMD5,ITGB3BP,NUP43,PSMC6,INCENP,SEC13,CENPM,LMNB1,AURKB,RANGAP1,ANAPC16,CKAP5,PPP2R5E,PPP2CA,PSMD13,MIR4523,CENPO,LEMD3,MAD1L1,SPDL1,CENPF,UBB,AHCTF1,PSMB5,ANAPC10,ANAPC4,CENPP,PPP1CC,NUP37,PSMC3,PPP2CB,KIF2C,SMC3,ANAPC7,CDC23,PSMB3,XPO1,ANAPC5,PSMD8,SPC24,PSMB9,SGO1,CLASP1,ZW10,SKA1,PSME1,PSMD14
R-HSA-3296482	Defects in vitamin and cofactor metabolism	0.856768396096979	-0.154587646503483	17	14	0.00154970112906797	9034	10285	8029,81693,4548,5096,166785,31,5091,4594,51293,56922,2694,4552,27249,5095	CUBN,AMN,MTR,PCCB,MMAA,ACACA,PC,MMUT,CD320,MCCC1,CBLIF,MTRR,MMADHC,PCCA
R-HSA-435354	Zinc transporters	0.856768396096979	-0.154587646503483	17	14	0.00154970112906797	9034	10285	64924,64116,55676,7779,57181,7780,169026,29985,7781,148867,23516,29986,25800,283375	SLC30A5,SLC39A8,SLC30A6,SLC30A1,SLC39A10,SLC30A2,SLC30A8,SLC39A3,SLC30A3,SLC30A7,SLC39A14,SLC39A2,SLC39A6,SLC39A5
R-HSA-159854	Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	5627,5045,2677,2147,2155,632,8858,2159,5624	PROS1,FURIN,GGCX,F2,F7,BGLAP,PROZ,F10,PROC
R-HSA-1855183	Synthesis of IP2, IP, and Ins in the cytosol	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	3628,3613,51477,3633,3631,27124,8821,8867,3612	INPP1,IMPA2,ISYNA1,INPP5B,INPP4A,INPP5J,INPP4B,SYNJ1,IMPA1
R-HSA-5685939	HDR through MMEJ (alt-NHEJ)	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	4361,10111,3980,142,4683,10038,7515,10721,2237	MRE11,RAD50,LIG3,PARP1,NBN,PARP2,XRCC1,POLQ,FEN1
R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	788,1374,5467,5565,7069,1376,6256,5563,51422	SLC25A20,CPT1A,PPARD,PRKAB2,THRSP,CPT2,RXRA,PRKAA2,PRKAG2
R-HSA-174490	Membrane binding and targetting of GAG proteins	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	7311,6233,7314,137492,9397,79720,7251,7316,55048	UBA52,RPS27A,UBB,VPS37A,NMT2,VPS37B,TSG101,UBC,VPS37C
R-HSA-174495	Synthesis And Processing Of GAG, GAGPOL Polyproteins	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	137492,9397,7314,7311,6233,7251,79720,55048,7316	VPS37A,NMT2,UBB,UBA52,RPS27A,TSG101,VPS37B,VPS37C,UBC
R-HSA-3296469	Defects in cobalamin (B12) metabolism	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	8029,81693,4594,4552,2694,4548,51293,27249,166785	CUBN,AMN,MMUT,MTRR,CBLIF,MTR,CD320,MMADHC,MMAA
R-HSA-1980148	Signaling by NOTCH3	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	51107,102,83464,182,4854,23385,3714,5664,54567	APH1A,ADAM10,APH1B,JAG1,NOTCH3,NCSTN,JAG2,PSEN2,DLL4
R-HSA-1980150	Signaling by NOTCH4	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	23385,3714,5664,54567,51107,102,4855,83464,182	NCSTN,JAG2,PSEN2,DLL4,APH1A,ADAM10,NOTCH4,APH1B,JAG1
R-HSA-196780	Biotin transport and metabolism	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	31,5091,32,56922,5096,5095,8884,686,3141	ACACA,PC,ACACB,MCCC1,PCCB,PCCA,SLC5A6,BTD,HLCS
R-HSA-73614	Pyrimidine salvage reactions	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	7371,100500832,7084,7083,7378,151531,978,83549,1633	UCK2,MIR3658,TK2,TK1,UPP1,UPP2,CDA,UCK1,DCK
R-HSA-381183	ATF6 (ATF6-alpha) activates chaperone genes	0.859238939407685	-0.151708235714811	11	9	0.000996236440115121	9034	10285	811,4801,3309,7494,22926,468,100500842,4800,4802	CALR,NFYB,HSPA5,XBP1,ATF6,ATF4,MIR3652,NFYA,NFYC
R-HSA-432720	Lysosome Vesicle Biogenesis	0.859983459760254	-0.150842122756451	36	30	0.00332078813371707	9034	10285	408,6456,9146,164,8907,81567,4074,1211,351,10053,162,1777,8673,1174,8906,9829,157807,3312,1213,1212,6844,134829,10717,130340,375,1522,2799,11154,1785,23431	ARRB1,SH3GL2,HGS,AP1G1,AP1M1,TXNDC5,M6PR,CLTA,APP,AP1M2,AP1B1,DNASE2,VAMP8,AP1S1,AP1G2,DNAJC6,CLVS1,HSPA8,CLTC,CLTB,VAMP2,CLVS2,AP4B1,AP1S3,ARF1,CTSZ,GNS,AP4S1,DNM2,AP4E1
R-HSA-452723	Transcriptional regulation of pluripotent stem cells	0.859983459760254	-0.150842122756451	36	30	0.00332078813371707	9034	10285	27086,6657,5431,2034,84891,5441,2516,79727,2247,9314,5434,4087,6774,6299,64344,5087,27022,79923,57167,63978,4089,6997,55211,5440,2649,5433,5439,5430,5432,5460	FOXP1,SOX2,POLR2B,EPAS1,ZSCAN10,POLR2L,NR5A1,LIN28A,FGF2,KLF4,POLR2E,SMAD2,STAT3,SALL1,HIF3A,PBX1,FOXD3,NANOG,SALL4,PRDM14,SMAD4,CRIPTO,DPPA4,POLR2K,NR6A1,POLR2D,POLR2J,POLR2A,POLR2C,POU5F1
R-HSA-212676	Dopamine Neurotransmitter Release Cycle	0.860969318580815	-0.149696409822535	23	19	0.00210316581802081	9034	10285	6616,8499,10497,9256,6854,5864,8825,8497,10815,55327,8500,8541,320,6571,6857,6812,22999,6844,8224	SNAP25,PPFIA2,UNC13B,TSPOAP1,SYN2,RAB3A,LIN7A,PPFIA4,CPLX1,LIN7C,PPFIA1,PPFIA3,APBA1,SLC18A2,SYT1,STXBP1,RIMS1,VAMP2,SYN3
R-HSA-389948	PD-1 signaling	0.860969318580815	-0.149696409822535	23	19	0.00210316581802081	9034	10285	917,919,915,1445,3127,29126,5781,80380,3119,3113,920,3118,5777,3932,916,3120,3122,3117,3123	CD3G,CD247,CD3D,CSK,HLA-DRB5,CD274,PTPN11,PDCD1LG2,HLA-DQB1,HLA-DPA1,CD4,HLA-DQA2,PTPN6,LCK,CD3E,HLA-DQB2,HLA-DRA,HLA-DQA1,HLA-DRB1
R-HSA-68882	Mitotic Anaphase	0.861476829948275	-0.149107118386538	179	153	0.0169360194819571	9034	10285	23421,5711,348995,5885,5694,81930,6396,79019,3619,5706,5528,5718,7112,6233,25906,6249,79902,4085,5707,151246,83540,23063,9184,5684,5048,7311,79980,5699,64105,11130,5700,23122,5713,9735,9700,51529,81929,57405,220134,23332,9183,151648,5698,10213,5720,5714,51433,5691,7514,8697,147841,401541,29945,5501,79023,5693,10393,9126,51434,11004,5516,5702,119504,9212,5905,4001,7314,1063,25909,54908,23592,79172,8379,9793,100616122,5529,5515,5719,699,5708,79682,9861,55055,23047,701,11065,7324,5525,5715,5519,5682,5717,5527,5701,55746,57122,25936,54820,64946,5526,122706,22919,7444,5692,55920,9491,10197,23198,4928,80152,996,81565,23244,55839,1062,7316,7979,143471,5347,3796,5520,5710,5704,23279,7443,4000,5696,84643,5903,9232,6232,991,5695,11243,7321,10726,5518,64682,57082,80776,10403,5690,5686,1058,221496,57551,1060,113130,332,10274,5687,8815,5685	ITGB3BP,PSMD5,NUP43,RAD21,PSMB6,KIF18A,SEC13,CENPM,INCENP,PSMC6,PPP2R5D,PSMD12,TMPO,RPS27A,ANAPC15,CLIP1,NUP85,MAD2L1,PSMD1,SGO2,NUF2,WAPL,BUB3,PSMA3,PAFAH1B1,UBA52,DSN1,PSMB10,CENPK,ZWINT,PSMC1,CLASP2,PSMD7,KNTC1,ESPL1,ANAPC11,SEH1L,SPC25,SKA1,CLASP1,ZW10,SGO1,PSMB9,PSMD14,PSME1,PSMD8,ANAPC5,PSMB3,XPO1,CDC23,SPC24,CENPP,ANAPC4,PPP1CC,NUP37,PSMB5,ANAPC10,SMC3,ANAPC7,KIF2C,PPP2CB,PSMC3,ANAPC16,AURKB,RANGAP1,LMNB1,UBB,CENPF,AHCTF1,SPDL1,LEMD3,CENPO,MAD1L1,CKAP5,MIR4523,PPP2R5E,PPP2CA,PSMD13,BUB1,PSMD2,CENPU,PSMD6,ZWILCH,PDS5B,BUB1B,UBE2C,UBE2E1,PPP2R5A,PSMD9,PPP2R1B,PSMA1,PSMD11,PPP2R5C,PSMC2,NUP133,NUP107,NSL1,NDE1,CENPH,PPP2R5B,PSMB11,MAPRE1,VRK2,PSMB4,RCC2,PSMF1,PSME3,PSME4,NUP98,CENPT,CDC27,NDEL1,PDS5A,CENPN,CENPE,UBC,SEM1,PSMA8,PLK1,KIF2A,PPP2R2A,PSMD4,PSMC4,NUP160,VRK1,LMNA,PSMB8,KIF2B,RANBP2,PTTG1,RPS27,CDC20,PSMB7,PMF1,UBE2D1,NUDC,PPP2R1A,ANAPC1,KNL1,B9D2,NDC80,PSMB2,PSMA5,CENPA,LEMD2,TAOK1,CENPC,CDCA5,BIRC5,STAG1,PSMA6,BANF1,PSMA4
R-HSA-72086	mRNA Capping	0.867514977550188	-0.142122502122628	29	24	0.00265663050697365	9034	10285	5433,5440,2968,5432,5439,5430,2965,1022,2967,6829,404672,8731,2071,5434,4686,902,2962,8732,2963,5431,4331,22916,2068,5441	POLR2D,POLR2K,GTF2H4,POLR2C,POLR2J,POLR2A,GTF2H1,CDK7,GTF2H3,SUPT5H,GTF2H5,RNMT,ERCC3,POLR2E,NCBP1,CCNH,GTF2F1,RNGTT,GTF2F2,POLR2B,MNAT1,NCBP2,ERCC2,POLR2L
R-HSA-445989	TAK1 activates NFkB by phosphorylation and activation of IKKs complex	0.867514977550188	-0.142122502122628	29	24	0.00265663050697365	9034	10285	64127,3656,4615,4791,6288,1660,8767,7189,351,10454,4793,6885,7334,10392,3146,3551,4792,4790,23118,1147,6283,7335,177,5970	NOD2,IRAK2,MYD88,NFKB2,SAA1,DHX9,RIPK2,TRAF6,APP,TAB1,NFKBIB,MAP3K7,UBE2N,NOD1,HMGB1,IKBKB,NFKBIA,NFKB1,TAB2,CHUK,S100A12,UBE2V1,AGER,RELA
R-HSA-212436	Generic Transcription Pathway	0.867707959714616	-0.141900072876127	865	750	0.0830197033429267	9034	10285	4850,10001,7559,388536,163059,284252,58528,8851,7029,5571,54989,5432,1459,8794,10224,5928,246175,30832,4361,4878,64065,7248,91875,80264,54971,94115,81857,9337,9167,7421,9612,147686,148203,10769,57060,83741,90576,332,7249,9134,285349,84126,6879,4929,23619,147923,54807,23112,57541,57103,5366,286075,6497,148206,4605,163051,79837,8856,339559,10650,55713,64769,1263,2626,3725,199704,3516,253639,6095,22869,9377,143686,9441,29028,7762,284459,10002,27244,26013,1020,57459,5433,388567,5984,4092,92595,54778,10308,2877,162967,7159,348,220992,10971,282890,144455,7832,55762,2100,1027,58484,126068,79230,6883,339500,148213,10499,2104,5883,5440,155054,204851,5371,1024,253260,10111,256051,9970,80108,27166,7181,353088,7773,1647,2962,7862,7586,7567,9099,57690,7323,79898,5494,5915,2965,57335,29883,6667,7534,10000,23774,57573,2068,3172,344787,7700,4869,64750,55786,56950,79109,9439,84124,84874,7469,2516,5465,23054,4292,9794,8649,55659,57677,6882,1616,8013,7733,158399,5515,9125,8648,51123,9212,7581,127396,83860,6258,79370,133383,1350,5810,4854,4331,138474,5308,2963,94039,581,126375,8797,155061,7913,7329,1082,10128,5325,1017,84527,7295,192669,51741,9891,5519,55422,6446,7161,5934,84883,10780,5468,284307,1111,2063,147657,11198,7376,5518,55888,22938,7587,55615,7566,1351,374928,5469,6790,355,374655,9219,23368,10172,54541,10498,10542,163087,5305,100287226,84987,219578,404672,93659,51230,192670,90338,9971,8738,124446,8463,898,5441,91120,1874,25937,51276,146434,90592,5395,4087,100302242,6118,116228,472,7561,51422,115509,6119,2968,619279,672,144715,7738,125919,641,389541,10413,1327,11200,10524,79788,9440,7936,79047,7531,163050,5457,162699,6923,387032,7625,83990,7003,7529,5608,6873,7768,80032,6827,545,221785,10793,7769,2101,7528,147948,5170,5052,94241,1107,440515,580,7576,162972,10781,27327,54205,5564,147741,51592,22835,4609,100302168,121274,29959,1956,84436,53615,80095,2033,6009,7695,112950,730087,654254,7022,5439,136051,4343,6875,7005,81856,57472,92285,3815,8850,6794,146542,8427,158431,84924,11073,27153,10848,84441,3486,1340,115196,55004,7710,10062,440519,162239,79759,4193,1026,3065,7692,7571,7025,374879,84246,10794,80110,55240,51003,1029,1763,79718,860,6498,51224,7157,2176,197320,342132,7627,904,5527,2908,2064,90317,84626,284309,27165,7673,7761,9442,63970,199777,53632,4436,5933,284306,29117,57336,126231,57474,84765,7341,51385,1386,8178,1875,100126332,79755,10025,54925,9443,3329,29982,163081,6877,2936,26149,374900,7766,57615,6096,7748,284443,3726,51333,100129842,148103,23327,9611,7422,349075,29079,112858,26974,162655,79088,843,665,2821,55215,9969,57343,7633,7020,163049,5241,7101,28984,51497,51058,163223,1345,1457,80196,207,27154,1820,148254,5431,2475,55778,5892,7027,113835,64121,7755,285268,7771,5563,51586,79986,23660,25824,91975,8812,7582,50484,2494,22974,169270,1482,8396,6881,902,55900,7004,59348,348327,6874,339327,54815,7486,100506888,168374,5300,5916,10520,900,7694,9422,90594,90333,55835,65243,7321,7752,26048,6924,28996,124411,84671,116028,2810,4194,100131827,835,6940,9477,342926,639,55367,163732,8445,79027,63934,995,1337,126382,5111,5565,7753,51241,5516,147694,9150,5562,80139,126070,4683,9310,57547,7314,3622,7568,891,387893,152687,728957,8089,93134,4221,2353,5054,80818,9656,9975,339488,7296,839,1329,117608,163071,79970,90075,388561,905,6117,604,57521,26152,25888,171392,4088,317,114026,7562,7994,147837,79818,162963,5985,353274,7565,8793,4089,4306,983,5982,133746,353355,5728,2967,7988,6917,57711,140612,117584,2649,10370,90649,56242,1353,6910,58491,6256,10168,10419,6604,2744,1643,100129543,6880,5983,23019,28956,4848,54811,80010,79744,10397,79943,7874,5467,7594,58492,146198,7770,6233,144348,199692,1869,5434,208,285676,79175,96764,146540,57209,9156,9572,388566,84838,3164,7068,1081,83667,4849,8795,170959,51755,7156,2177,55534,9540,7001,401509,169841,147949,148266,7316,892,7678,285267,6749,10765,6921,4855,3364,7745,7533,84914,2099,90874,2071,100302237,90390,8626,4697,5430,83744,1490,25946,27113,7039,8900,8431,389114,6884,390927,100131980,65988,7021,2103,5884,26523,84775,890,25904,7551,84449,1387,79973,3276,7760,7743,6341,7311,5600,83695,5458,1022,4853,5914,10670,5876,1030,285521,55571,441234,7621,7767,6097,834,9668,1108,255403,3174,6829,85441,64223,60436,10919,85456,8621,80205,1432,142,7638,7050,163255,7532,440077,27161,3066	CNOT4,MED6,ZNF12,ZNF790,ZNF433,KCTD1,RRAGD,CDK5R1,TFDP2,PRKAG1,ZNF770,POLR2C,CSNK2A2,TNFRSF10C,ZNF443,RBBP4,CNOT6L,ZNF354C,MRE11,NPPA,PERP,TSC1,TTC5,ZNF430,BANP,CGB8,MED25,CNOT8,COX7A2L,VDR,NCOR2,ZNF418,ZNF738,PLK2,PCBP4,TFAP2D,ZNF799,BIRC5,TSC2,CCNE2,ZNF660,ATRIP,TAF7,NR4A2,ZIM2,ZNF420,ZNF586,TNRC6B,ZNF398,TIGAR,PMAIP1,ZNF707,SKI,ZNF714,MYBL2,ZNF709,PIP4K2C,NR1I2,ZFP69,PRELID3A,ZNF334,MEAF6,PLK3,GATA4,JUN,ZNF585A,RBPJ,ZNF620,RORA,ZNF510,COX5A,SESN3,MED26,ATAD2,ZNF215,ZNF875,NR2E3,SESN1,L3MBTL1,CDK5,GATAD2B,POLR2D,ZNF749,RFC4,SMAD7,ZNF764,RNF111,ZNF267,GPX2,ZNF320,TP53BP2,APOE,ZNF485,YWHAQ,ZNF311,E2F7,BTG2,ZNF701,ESR2,CDKN1B,NLRC4,ZNF441,ZNF557,TAF12,ZNF678,ZNF681,NCOA2,ESRRG,RAD9A,POLR2K,ZNF425,HIPK1,PML,CDK8,RICTOR,RAD50,ZNF549,NR1I3,ZFP2,PRELID1,NR2C1,ZNF429,ZNF230,GADD45A,GTF2F1,BRPF1,ZKSCAN1,ZNF19,USP2,TNRC6C,UBE2D3,ZNF613,PPM1A,RARB,GTF2H1,ZNF286A,CNOT7,SP1,YWHAZ,AKT3,BRD1,ZNF471,ERCC2,HNF4A,ZNF860,ZNF141,NPM1,SMURF2,ZNF415,SMYD2,MAPKAP1,MED23,ZNF394,ZNF514,NELFA,NR5A1,PPARA,NCOA6,MLH1,MAML1,LAMTOR3,ZNF416,ZFP14,TAF11,DAXX,NR4A3,ZNF180,ZNF483,PPP2CA,CNOT9,NCOA1,ZNF706,AURKB,ZNF33A,ZNF684,TAF3,RXRG,BCL2L14,SETD9,COX7C,RAD1,NOTCH3,MNAT1,TAF1L,PITX2,GTF2F2,ZNF101,BAX,ZNF792,TNFRSF10A,ZNF746,DEK,UBE2I,CGB3,LRPPRC,PLAGL1,CDK2,ZNF559,TXN,AGO3,WWOX,NUAK1,PPP2R1B,ZNF331,SGK1,TP73,RBL2,AIFM2,ZNF234,PPARG,ZIK1,CHEK1,NR2F6,ZNF480,SUPT16H,NR1H2,PPP2R1A,ZKSCAN7,SNW1,ZNF37A,PRR5,ZNF18,COX8A,ZNF773,MED1,AURKA,FAS,ZNF710,MTA2,PPP1R13B,ZNF256,DDIT4,CARM1,LAMTOR5,ZNF383,PIP4K2A,ZNF729,COX14,ZNF804B,GTF2H5,CGB5,PHF20,AGO4,ZNF160,NR1H4,CRADD,TMEM219,TEAD2,CCNE1,POLR2L,ZNF682,E2F4,WWTR1,ZNF571,ZNF597,ZNF700,PMS2,SMAD2,MIR1236,RPA2,COX20,ATM,ZNF14,PRKAG2,ZNF689,RPA3,GTF2H4,ZNF704,BRCA1,RAD9B,ZNF184,ZNF543,BLM,LAMTOR4,YAP1,COX4I1,CHEK2,KAT5,ZNF665,MED17,NELFE,KCTD15,YWHAE,ZNF564,POU4F1,ELOA3P,ELOB,ZKSCAN4,ZNF74,BRIP1,TEAD1,YWHAB,MAP2K6,TAF2,ZNF225,ZNF556,SUPT4H1,ATR,ZSCAN25,ZNF273,ZNF226,ESRRA,YY1,ZNF582,PDPK1,PRDX1,TP53INP1,CHD3,ZNF506,BARD1,ZNF28,ZNF550,ZNF266,TNRC6A,CYCS,PRKAB1,ZNF560,TRIM33,ZFP30,MYC,MIR1257,ZNF641,NRBP1,EGFR,ZNF528,MBD3,ZNF606,EP300,RHEB,ZNF136,MED8,ZNF726,ZNF732,TFAP2C,POLR2J,ZNF786,MOV10,TAF4B,TEAD3,ZNF611,CNOT6,ZNF585B,KIT,KAT2B,STK11,ZNF688,ZNF282,ZNF782,ZNF566,TOPBP1,ZNF777,PPP1R13L,MAML2,IGFBP3,COX6B1,ZNF554,LAMTOR1,ZNF154,NR1H3,ZNF724,ZFP1,ZNF668,MDM2,CDKN1A,HDAC1,ZNF133,ZNF23,NR2F1,ZNF699,MED10,ZNF460,ZNF614,STEAP3,MED31,CDKN2A,DNA2,TBL1XR1,RUNX2,SKIL,ELOA2,TP53,FANCC,ZNF778,ZNF774,ZNF75A,CCNT1,PPP2R5C,NR3C1,ERBB2,ZNF616,KRBA1,ZNF776,GLS2,ZNF222,ZNF214,MED27,TP53AIP1,ZNF626,PRKAG3,MSH2,RBL1,ZNF547,BRD7,ZNF287,ZNF573,ZNF490,ZNF577,SUMO1,ZNF589,ATF2,ELL,E2F5,MIR943,ZNF750,MED16,ZSCAN32,MED7,HSPD1,NRBF2,ZNF567,TAF5,GSR,ZNF658,ZNF568,ZNF223,ZNF492,RORB,ZNF195,ZNF493,JUNB,ZNF771,ZNF737,ZNF599,NEDD4L,NCOR1,VEGFA,ZNF713,MED4,TP53RK,ZNF285,ZNF519,ZNF426,CASP10,BNIP3L,GPI,FANCI,MED13,ZNF304,ZNF79,TFAP2A,ZNF791,PGR,NR2E1,RGCC,NELFCD,ZNF691,ZNF676,COX6C,CSNK2A1,RNF34,AKT1,BRPF3,ARID3A,ZNF555,POLR2B,MTOR,ZNF839,RAD51D,TFDP1,ZNF257,RRAGC,ZNF205,ZNF621,ZNF112,PRKAA2,MED15,ZNF702P,ZKSCAN5,PRDX5,ZNF300,CCNK,ZNF33B,RRM2B,NR5A2,TPX2,ZNF596,NKX2-5,PIP4K2B,TAF10,CCNH,ZNF302,TEAD4,ZNF350,ZNF530,TAF4,ZNF546,GATAD2A,WRN,ELOA3DP,ZNF92,PIN1,RARG,ZNF211,CCNG1,ZNF135,ZNF264,ZNF439,ZNF468,CENPJ,ZFP69B,UBE2D1,ZNF200,ZNF500,ELOA,HIPK2,KRBOX5,ZNF347,RMI2,SFN,MDM4,ZNF717,CASP2,ZNF354A,MED20,ZNF677,PRDM1,PIDD1,CITED4,DYRK2,ZNF655,ZNF667,CDC25C,COX6A1,NR2C2AP,PCNA,PRKAB2,ZNF202,COX16,PPP2CB,ZNF548,CTDP1,PRKAA1,ZNF703,ZNF440,NBN,ZNF235,ZNF624,UBB,ING2,ZNF20,CCNB1,KMT5A,ZNF595,ZNF705D,YEATS4,ZNF561,MEN1,FOS,SERPINE1,ZNF436,MDC1,NR1D2,TFAP2E,TXNRD1,CASP6,COX5B,ZNF354B,ZNF114,ZNF767P,ZNF30,ZNF761,CCNT2,RPA1,BCL6,RPTOR,ZNF337,ZNF473,ZNF675,SMAD3,APAF1,ZIM3,ZNF708,KAT6A,ZNF563,ZNF552,ZNF610,RFC5,ZNF445,ZNF17,TNFRSF10D,SMAD4,NR3C2,CDK1,RFC2,JMY,ZNF233,PTEN,GTF2H3,ZNF212,TCEA1,ZNF529,ZFP28,RFFL,NR6A1,CITED2,ZNF486,ZNF253,COX11,TBX5,ZNF71,RXRA,ZNF197,PRMT5,SMARCD3,GLS,DDB2,ZNF730,TAF9,RFC3,CNOT1,LAMTOR2,CNOT2,ZNF562,RMI1,ZNF419,NDRG1,ZNF696,USP7,PPARD,ZNF43,ZNF77,ZFP90,ZNF227,RPS27A,ZNF664,ZNF627,E2F1,POLR2E,AKT2,ZNF454,ZNF343,TGS1,ZNF785,ZNF248,EXO1,NR1D1,ZNF470,ZNF496,NR4A1,THRB,CGA,SESN2,CNOT3,TNFRSF10B,ZNF431,CDK12,TOP3A,FANCD2,MAML3,TP53I3,PRDX2,ZNF658B,ZNF169,ZNF583,ZNF569,UBC,CCNC,ZNF124,ZNF619,SSRP1,KDM5B,ELOC,NOTCH4,HUS1,ZKSCAN8,YWHAH,ZNF587,ESR1,ZNF697,ERCC3,MIR1281,MED30,TP63,NDUFA4,POLR2A,ZNF484,CCN2,ZNF385A,BBC3,TGFA,CCNA1,NR0B2,ZNF662,TAF13,ZNF793,ZNF705G,ZNF747,TFAP2B,ESRRB,RAD17,AGO1,ZNF607,CCNA2,CNOT10,ZNF3,ZNF333,CREBBP,ZNF442,PRMT1,ZNF213,ZNF189,SCO1,UBA52,MAPK11,RHNO1,POU4F2,CDK7,NOTCH2,RARA,RRAGA,RABGGTB,CDKN2B,COX18,CNOT11,ZNF716,ZNF70,ZNF224,RORC,CASP1,ZNF432,CHD4,ZNF718,HNF4G,SUPT5H,HELZ2,MLST8,TGIF2,EHMT2,TNKS1BP1,CDK13,CHD9,MAPK14,PARP1,ZNF221,TGIF1,ZNF540,YWHAG,ZNF705A,AGO2,HDAC2
R-HSA-1640170	Cell Cycle	0.871180090597296	-0.137906560474268	621	537	0.0594421075935355	9034	10285	8357,5706,5566,5885,995,157570,8615,81930,23353,4292,4085,7013,151246,23224,5111,8468,116028,64105,2810,56154,4194,7298,83540,896,94239,121441,8350,129401,9577,9978,891,51720,151648,10112,387893,5810,23332,4331,5424,55320,7840,3021,9656,5714,675,5516,5702,9126,51434,723790,8364,7468,401541,79172,4683,8379,55706,5515,23595,10121,7314,1063,22994,993,91754,9212,84057,5682,8339,10133,79682,56655,22974,10111,8467,23047,8945,54801,54892,84296,23291,9493,8968,25936,1454,5701,10776,8358,902,9491,22919,7015,8370,5883,9631,23594,126961,4149,1062,22995,55651,80152,286826,128312,140609,7443,23279,23511,55835,64151,23225,2237,7321,4869,256126,5686,221496,8454,80776,10403,80184,64900,4660,10926,84930,8815,5685,7486,8359,7534,8290,10000,51659,5594,81876,8970,3161,7084,79019,3619,2801,132660,348995,22822,5718,4998,5528,4927,7158,23122,8368,3017,4605,23345,8346,81929,57405,27030,55388,51529,55722,95681,9700,9735,8345,9663,80028,5984,5001,1457,207,79959,4173,8318,9183,23175,10426,10971,1871,5691,7514,8697,84142,1027,63943,7027,11004,23194,6241,5693,57804,11190,79023,9918,100616122,9688,5719,5529,4999,25909,4171,4001,1032,8343,5527,5717,5928,1031,10762,8360,4172,4361,9861,55055,80254,9662,699,5427,5108,4659,8607,55746,51588,984,5692,122706,1029,8334,1763,9088,7029,51512,80321,8341,143471,4218,5347,3796,5710,5520,1459,8367,3018,10856,7979,23198,4928,7157,25836,996,81565,84643,1028,84962,5696,6500,7341,8317,5500,5695,10733,7334,84515,1875,991,8655,9232,8354,64785,23310,10388,3320,5933,57060,4175,332,113130,9134,84126,4957,7153,93323,8363,5711,23421,8340,79902,595,6249,10142,5925,79866,11144,5577,1639,2033,11130,5595,7311,91750,5699,3015,85378,83695,1022,5684,4926,994,8361,5713,1030,7175,2029,8347,8556,5558,11064,23165,100101267,10213,4193,5698,55755,220134,1026,3065,10540,147841,7532,3012,51773,25913,4438,11073,10393,5501,11339,7014,9793,54908,9702,119504,5905,5715,5525,79441,83990,7529,11065,1719,7324,6502,165918,10806,1781,27175,5526,201254,54820,3013,10051,64946,23397,3364,57122,545,653604,7533,51053,10524,10197,5557,8348,7444,121504,8366,387103,9883,7531,8021,1859,3306,7156,50511,54107,8365,23244,55355,7316,26271,5578,255919,8900,5903,8362,4000,580,5704,8349,3326,5579,1021,79648,5884,26003,56979,890,4609,10714,1058,54069,100302237,5690,10592,11258,1870,81620,10274,11083,10783,63967,25946,5000,10382,1453,9818,8355,6396,1874,65057,5694,22897,5707,22981,6233,5981,25906,7336,6118,1869,7112,5700,5983,79980,114791,5048,4174,23063,9184,23354,80010,898,5720,672,9156,144715,990,8924,3978,55766,641,53371,51433,1019,11200,208,472,55125,728642,5862,27127,29945,51343,23592,6119,8335,8352,7846,54930,6117,5519,23636,23649,64689,701,6847,115106,5708,8548,5934,23383,5888,5861,5985,9133,55920,55135,894,7329,1017,8086,9025,7277,55839,25777,1778,8353,9814,203068,9837,64326,9972,11243,6232,55957,8344,4751,1111,57082,6418,29086,983,64682,3020,5982,10726,26277,5518,5753,11097,5687,7465,57551,1060,84131,5889,6790	H3C10,PSMC6,PRKACA,RAD21,CDC25C,ESCO2,USO1,KIF18A,SUN1,MLH1,MAD2L1,TERF1,SGO2,SYNE2,PCNA,FKBP6,RMI2,CENPK,SFN,TEX15,MDM4,TYMS,NUF2,CCND3,H2AZ2,NEDD1,H3C1,NUP35,BABAM2,RBX1,CCNB1,UIMC1,SGO1,KIF20A,KMT5A,RAD1,CLASP1,MNAT1,POLD1,MIS18BP1,ALMS1,H3-3B,MDC1,PSMD8,BRCA2,PPP2CB,PSMC3,SMC3,ANAPC7,H2AC19,H4C3,NSD2,CENPP,CENPO,NBN,MAD1L1,NDC1,PPP2CA,ORC3,ACTR1A,UBB,CENPF,CEP131,CDC25A,NEK9,AURKB,MND1,PSMA1,H2BC8,OPTN,CENPU,POLE4,TPX2,RAD50,SMARCA5,PDS5B,BTRC,HAUS6,NCAPG2,GINS4,FBXW11,KIF23,H3C7,NSL1,CSNK1E,PSMC2,ARPP19,H3C2,CCNH,PSMF1,MAPRE1,TERT,H4C14,RAD9A,NUP155,ORC6,H3C14,MAX,CENPE,CEP152,NHP2,CENPT,LIN9,H2BC26,NEK7,VRK1,NUP160,NUP188,CENPJ,NCAPG,NUP210,FEN1,UBE2D1,NPM1,SYCE2,PSMA5,LEMD2,CUL1,B9D2,NDC80,CEP290,LPIN3,PPP1R12B,DBF4,MASTL,BANF1,PSMA4,WRN,H4C1,YWHAZ,H3-4,AKT3,GINS2,MAPK1,RAB1B,H2BC11,HMMR,TK2,CENPM,INCENP,GOLGA2,LIN54,NUP43,PHLDA1,PSMD12,ORC1,PPP2R5D,NUP88,TP53BP1,CLASP2,H4C13,H2BC5,MYBL2,SYNE1,H2BC10,SEH1L,SPC25,MLH3,MCM10,ANAPC11,CEP72,CEP41,ESPL1,KNTC1,H2BC9,LPIN2,FBXL18,RFC4,ORC5,CSNK2A1,AKT1,CEP76,MCM4,CDC45,ZW10,LPIN1,TUBGCP3,YWHAQ,E2F3,PSMB3,XPO1,CDC23,ABRAXAS1,CDKN1B,FKBPL,TFDP1,KIF2C,FBXL7,RRM2,PSMB5,POLD4,CEP250,NUP37,NCAPD2,MIR4523,NUP93,PSMD13,PPP2R5E,ORC2,AHCTF1,MCM2,LMNB1,CDKN2D,H2BC7,PPP2R5C,PSMD11,RBBP4,CDKN2C,NUP50,H4C4,MCM3,MRE11,PSMD6,ZWILCH,CEP63,CEP135,BUB1,POLE2,PCM1,PPP1R12A,RUVBL1,NUP133,PIAS4,CDK11B,PSMB4,PSMB11,CDKN2A,H2AC6,DNA2,PKMYT1,TFDP2,GTSE1,CEP70,H2BC15,PSMA8,RAB8A,PLK1,KIF2A,PSMD4,PPP2R2A,CSNK2A2,H4C5,H2BC3,RUVBL2,SEM1,PSME4,NUP98,TP53,NIPBL,CDC27,NDEL1,KIF2B,CDKN1C,AJUBA,PSMB8,SKP1,SUMO1,CDC7,PPP1CB,PSMB7,PLK4,UBE2N,MCM8,E2F5,CDC20,DYNLL1,PTTG1,H3C11,GINS3,NCAPD3,SYCP2,HSP90AA1,RBL1,PCBP4,MCM6,BIRC5,CDCA5,CCNE2,ATRIP,ODF2,TOP2A,HAUS8,H4C11,PSMD5,ITGB3BP,H2BC13,NUP85,CCND1,CLIP1,AKAP9,RB1,BORA,DMC1,PRKAR2B,DCTN1,EP300,ZWINT,MAPK3,UBA52,LIN52,PSMB10,H2AZ1,TUBGCP6,RHNO1,CDK7,PSMA3,NUMA1,CDC25B,H4C6,PSMD7,CDKN2B,TPR,ENSA,H2BC4,CDC14A,PRIM2,CNTRL,NUP205,POM121C,PSMD14,MDM2,PSMB9,CDK5RAP2,SKA1,CDKN1A,HDAC1,DCTN2,SPC24,YWHAG,H2AC8,RSF1,POT1,MSH4,TOPBP1,ANAPC10,PPP1CC,OIP5,TERF2,CKAP5,SPDL1,CEP57,ANAPC16,RANGAP1,PSMD9,PPP2R5A,HAUS3,BRIP1,YWHAB,UBE2C,DHFR,UBE2E1,SKP2,RNF168,SDCCAG8,DYNC1I2,TUBG2,PPP2R5B,CENPX,NDE1,H2AC7,SMC4,CENPH,NCAPH,HUS1,NUP107,ATR,H3C13,YWHAH,GMNN,KAT5,PSME3,PRIM1,H2BC17,VRK2,H4C16,H4C2,CENPW,POM121,YWHAE,NUP214,DYRK1A,HSPA2,TOP3A,SYCP3,POLE3,H4C8,PDS5A,HJURP,UBC,FBXO5,PRKCA,CNEP1R1,CCNA1,RANBP2,H4C12,LMNA,BARD1,PSMC4,H2BC21,HSP90AB1,PRKCB,CDK6,MCPH1,RAD17,GORASP2,PRDM9,CCNA2,MYC,POLD3,CENPA,MIS18A,MIR1281,PSMB2,SMC2,DCTN3,E2F2,CDT1,STAG1,DIDO1,NEK6,CLSPN,ZNF385A,ORC4,TUBB4A,CSNK1D,NUP58,H3C8,SEC13,E2F4,ACD,PSMB6,CEP164,PSMD1,NINL,RPS27A,RFC1,ANAPC15,UBE2V2,RPA2,E2F1,TMPO,PSMC1,RFC3,DSN1,TUBGCP5,PAFAH1B1,MCM5,WAPL,BUB3,HAUS5,RMI1,CCNE1,PSME1,BRCA1,EXO1,RAD9B,CDC6,HERC2,LIG1,H2AJ,BLM,NUP54,ANAPC5,CDK4,CHEK2,AKT2,ATM,CEP192,CDK11A,RAB2A,SMC1B,ANAPC4,FZR1,LEMD3,RPA3,H2AC4,H3C3,TUBA1A,HAUS4,RPA1,PPP2R1B,NUP62,POLA2,GORASP1,BUB1B,SYCP1,HAUS1,PSMD2,BLZF1,RBL2,MAU2,RAD51,RAB1A,RFC5,CCNB2,RCC2,WRAP53,CCND2,UBE2I,CDK2,AAAS,RNF8,TUBA4A,CENPN,SUN2,DYNC1H1,H3C6,SFI1,TUBB,GINS1,COP1,NUP153,PMF1,RPS27,LIN37,H2BC6,NEK2,CHEK1,KNL1,SET,BABAM1,CDK1,ANAPC1,H3-3A,RFC2,NUDC,TINF2,PPP2R1A,PTK6,NUP42,PSMA6,WEE1,TAOK1,CENPC,CEP78,RAD51C,AURKA
R-HSA-5619115	Disorders of transmembrane transporters	0.872414795347182	-0.136490285436731	76	64	0.00708434801859641	9034	10285	91445,5714,6400,5691,551,5695,10613,5704,5698,10213,5696,5720,553,6833,213,7314,5719,5685,5687,1080,5693,5690,5702,5686,5718,10956,2646,5701,653509,6441,3767,7415,6233,5707,5708,2645,5711,11160,5694,9861,5717,5706,5715,5682,5713,23198,7316,7979,143471,5710,6048,5684,122706,91319,552,6439,5692,5699,7311,79139,9491,5700,10197,729238	RNF185,PSMD8,SEL1L,PSMB3,AVP,PSMB7,ERLIN1,PSMC4,PSMB9,PSMD14,PSMB8,PSME1,AVPR1B,ABCC8,ALB,UBB,PSMD13,PSMA4,PSMA6,CFTR,PSMB5,PSMB2,PSMC3,PSMA5,PSMD12,OS9,GCKR,PSMC2,SFTPA1,SFTPD,KCNJ11,VCP,RPS27A,PSMD1,PSMD2,GCK,PSMD5,ERLIN2,PSMB6,PSMD6,PSMD11,PSMC6,PSMD9,PSMA1,PSMD7,PSME4,UBC,SEM1,PSMA8,PSMD4,RNF5,PSMA3,PSMB11,DERL3,AVPR1A,SFTPB,PSMB4,PSMB10,UBA52,DERL1,PSMF1,PSMC1,PSME3,SFTPA2
R-HSA-5619084	ABC transporter disorders	0.872643271587336	-0.136228430263212	69	58	0.006420190391853	9034	10285	7314,5685,5719,5687,6833,5690,5702,5686,5693,1080,5695,10613,91445,5714,6400,5691,5696,10213,5720,5704,5698,5710,143471,6048,23198,5713,7979,7316,5699,5692,79139,7311,5700,10197,729238,9491,5684,122706,91319,6439,7415,3767,6233,5707,10956,5718,5701,6441,653509,5706,5717,5682,5715,5708,11160,5711,9861,5694	UBB,PSMA4,PSMD13,PSMA6,ABCC8,PSMB2,PSMC3,PSMA5,PSMB5,CFTR,PSMB7,ERLIN1,RNF185,PSMD8,SEL1L,PSMB3,PSMB8,PSMD14,PSME1,PSMC4,PSMB9,PSMD4,PSMA8,RNF5,PSME4,PSMD7,SEM1,UBC,PSMB10,PSMB4,DERL1,UBA52,PSMC1,PSME3,SFTPA2,PSMF1,PSMA3,PSMB11,DERL3,SFTPB,VCP,KCNJ11,RPS27A,PSMD1,OS9,PSMD12,PSMC2,SFTPD,SFTPA1,PSMC6,PSMD11,PSMA1,PSMD9,PSMD2,ERLIN2,PSMD5,PSMD6,PSMB6
R-HSA-428157	Sphingolipid metabolism	0.873270118360675	-0.135510357071399	90	76	0.00841266327208324	9034	10285	23683,83850,123099,427,340075,79411,8879,7368,285362,5660,2583,221,10087,153642,79603,56848,55331,55512,1455,10825,339221,55304,57704,79642,5007,91012,79152,4758,6609,7357,57733,8612,94101,2629,80772,2581,151742,165679,51228,9517,23344,125981,171546,9218,64781,55627,10715,25865,57488,81537,8611,5587,253782,29095,259230,8706,9217,411,10558,8613,340485,224,2760,130367,56624,22901,2531,29956,2720,3074,8877,166929,222,6610,204219,8560	PRKD3,ESYT3,DEGS2,ASAH1,ARSI,GLB1L,SGPL1,UGT8,SUMF1,PSAP,B4GALNT1,ALDH3B1,CERT1,ARSK,CERS4,SPHK2,ACER3,SMPD3,CSNK1G2,NEU3,ENPP7,SPTLC3,GBA2,ARSJ,OSBP,CERS5,FA2H,NEU1,SMPD1,UGCG,GBA3,PLPP2,ORMDL1,GBA1,CPTP,GALC,PPM1L,SPTSSB,GLTP,SPTLC2,ESYT1,ACER1,SPTSSA,VAPA,CERK,SMPD4,CERS1,PRKD2,ESYT2,SGPP1,PLPP1,PRKD1,CERS6,ORMDL2,SGMS1,B3GALNT1,VAPB,ARSB,SPTLC1,PLPP3,ACER2,ALDH3A2,GM2A,SGPP2,ASAH2,ARSG,KDSR,CERS2,GLB1,HEXB,SPHK1,SGMS2,ALDH3B2,SMPD2,CERS3,DEGS1
R-HSA-5678895	Defective CFTR causes cystic fibrosis	0.873493060193871	-0.135255094266293	62	52	0.00575603276510959	9034	10285	5698,5704,5720,5696,10213,6400,5691,91445,5714,10613,5695,5693,1080,5702,5686,5690,5685,5719,5687,7314,9861,5694,5708,11160,5711,5706,5717,5682,5715,5718,10956,5701,5707,7415,6233,91319,5684,122706,10197,5700,9491,5699,5692,79139,7311,7316,7979,23198,5713,5710,143471,6048	PSMB9,PSMC4,PSME1,PSMB8,PSMD14,SEL1L,PSMB3,RNF185,PSMD8,ERLIN1,PSMB7,PSMB5,CFTR,PSMC3,PSMA5,PSMB2,PSMA4,PSMD13,PSMA6,UBB,PSMD6,PSMB6,PSMD2,ERLIN2,PSMD5,PSMC6,PSMD11,PSMA1,PSMD9,PSMD12,OS9,PSMC2,PSMD1,VCP,RPS27A,DERL3,PSMA3,PSMB11,PSME3,PSMC1,PSMF1,PSMB10,PSMB4,DERL1,UBA52,UBC,SEM1,PSME4,PSMD7,PSMD4,PSMA8,RNF5
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	0.874846993840744	-0.133706272097053	35	29	0.0032100951959265	9034	10285	22916,5431,4331,7469,5441,2068,2962,100302242,5434,4686,902,2963,6827,7936,2967,1022,2965,2071,100126332,404672,9150,6829,51497,5440,5433,2968,5432,5430,5439	NCBP2,POLR2B,MNAT1,NELFA,POLR2L,ERCC2,GTF2F1,MIR1236,POLR2E,NCBP1,CCNH,GTF2F2,SUPT4H1,NELFE,GTF2H3,CDK7,GTF2H1,ERCC3,MIR943,GTF2H5,CTDP1,SUPT5H,NELFCD,POLR2K,POLR2D,GTF2H4,POLR2C,POLR2A,POLR2J
R-HSA-113418	Formation of the Early Elongation Complex	0.874846993840744	-0.133706272097053	35	29	0.0032100951959265	9034	10285	7936,2965,1022,2967,404672,2071,100126332,6829,9150,51497,5433,5440,5432,2968,5430,5439,22916,5431,4331,5441,7469,2068,4686,5434,902,2962,100302242,2963,6827	NELFE,GTF2H1,CDK7,GTF2H3,GTF2H5,ERCC3,MIR943,SUPT5H,CTDP1,NELFCD,POLR2D,POLR2K,POLR2C,GTF2H4,POLR2A,POLR2J,NCBP2,POLR2B,MNAT1,POLR2L,NELFA,ERCC2,NCBP1,POLR2E,CCNH,GTF2F1,MIR1236,GTF2F2,SUPT4H1
R-HSA-5263617	Metabolism of ingested MeSeO2H into MeSeH	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	7296	TXNRD1
R-HSA-1222352	Latent infection of Homo sapiens with Mycobacterium tuberculosis	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	4057	LTF
R-HSA-389542	NADPH regeneration	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	3417	IDH1
R-HSA-1299344	TWIK-related spinal cord K+ channel (TRESK)	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	338567	KCNK18
R-HSA-1483196	PI and PC transport between ER and Golgi membranes	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	23760	PITPNB
R-HSA-1483076	Synthesis of CL	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	54675	CRLS1
R-HSA-164525	Plus-strand DNA synthesis	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5478	PPIA
R-HSA-163316	Mitochondrial transcription termination	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	7978	MTERF1
R-HSA-5083633	Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	1605	DAG1
R-HSA-5619110	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	213	ALB
R-HSA-171286	Synthesis and processing of ENV and VPU	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5045	FURIN
R-HSA-5657655	MGMT-mediated DNA damage reversal	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	4255	MGMT
R-HSA-8853333	Signaling by FGFR2 fusions	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	2263	FGFR2
R-HSA-112122	ALKBH2 mediated reversal of alkylation damage	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	121642	ALKBH2
R-HSA-2978092	Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	3417	IDH1
R-HSA-2466712	Biosynthesis of A2E, implicated in retinal degradation	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	222236	NAPEPLD
R-HSA-5467333	APC truncation mutants are not K63 polyubiquitinated	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	324	APC
R-HSA-2408552	Methylation of MeSeH for excretion	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	11185	INMT
R-HSA-3359457	Defective GIF causes intrinsic factor deficiency	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	2694	CBLIF
R-HSA-5602410	TLR3 deficiency - HSE	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	7098	TLR3
R-HSA-3248023	Regulation by TREX1	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	11277	TREX1
R-HSA-190840	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	2697	GJA1
R-HSA-2033515	t(4;14) translocations of FGFR3	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	2261	FGFR3
R-HSA-5602415	UNC93B1 deficiency - HSE	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	7098	TLR3
R-HSA-5083628	Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	1605	DAG1
R-HSA-164516	Minus-strand DNA synthesis	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5478	PPIA
R-HSA-1299287	Tandem pore domain halothane-inhibited K+ channel (THIK)	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	56659	KCNK13
R-HSA-2142696	Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	239	ALOX12
R-HSA-2023837	Signaling by FGFR2 amplification mutants	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	2263	FGFR2
R-HSA-5250982	Toxicity of tetanus toxin (TeNT)	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	6844	VAMP2
R-HSA-1222449	Mtb iron assimilation by chelation	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	4057	LTF
R-HSA-1839120	Signaling by FGFR1 amplification mutants	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	2260	FGFR1
R-HSA-1855231	Synthesis of IPs in the ER lumen	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	9562	MINPP1
R-HSA-5619058	Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	213	ALB
R-HSA-140180	COX reactions	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5742	PTGS1
R-HSA-1222499	Response of Mtb to phagocytosis	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	4057	LTF
R-HSA-975574	Reactions specific to the hybrid N-glycan synthesis pathway	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	4248	MGAT3
R-HSA-6809583	Retinoid metabolism disease events	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5950	RBP4
R-HSA-2534343	Interaction With Cumulus Cells	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	6677	SPAM1
R-HSA-169131	Inhibition of PKR	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5610	EIF2AK2
R-HSA-1839128	FGFR4 mutant receptor activation	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	2264	FGFR4
R-HSA-162589	Reverse Transcription of HIV RNA	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5478	PPIA
R-HSA-5083629	Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	1605	DAG1
R-HSA-162585	Uncoating of the HIV Virion	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	5478	PPIA
R-HSA-211957	Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	0.878366553237692	-0.129691285867011	1	1	0.000110692937790569	9034	10285	1544	CYP1A2
R-HSA-140837	Intrinsic Pathway of Fibrin Clot Formation	0.879827459584385	-0.128029459387964	22	18	0.00199247288023024	9034	10285	2815,3827,5547,2159,2147,5270,3818,5104,7450,2161,710,2811,2,5624,2160,462,2814,3053	GP9,KNG1,PRCP,F10,F2,SERPINE2,KLKB1,SERPINA5,VWF,F12,SERPING1,GP1BA,A2M,PROC,F11,SERPINC1,GP5,SERPIND1
R-HSA-749476	RNA Polymerase III Abortive And Retractive Initiation	0.88230909758399	-0.125212833593376	41	34	0.00376355988487934	9034	10285	55703,4781,55290,5441,6618,9329,51728,2976,2971,10302,7702,4784,9330,10622,5434,6617,2975,55718,112495,27297,171568,84265,6619,10623,9328,11128,661,4774,9533,51082,5451,5440,6741,4782	POLR3B,NFIB,BRF2,POLR2L,SNAPC2,GTF3C4,POLR3K,GTF3C2,GTF3A,SNAPC5,ZNF143,NFIX,GTF3C3,POLR3G,POLR2E,SNAPC1,GTF3C1,POLR3E,GTF3C6,CRCP,POLR3H,POLR3GL,SNAPC3,POLR3C,GTF3C5,POLR3A,POLR3D,NFIA,POLR1C,POLR1D,POU2F1,POLR2K,SSB,NFIC
R-HSA-74158	RNA Polymerase III Transcription	0.88230909758399	-0.125212833593376	41	34	0.00376355988487934	9034	10285	6618,5441,55290,9329,4781,55703,2976,51728,10622,9330,10302,2971,4784,7702,2975,55718,27297,112495,6617,5434,171568,84265,11128,6619,10623,9328,9533,4774,661,4782,6741,51082,5451,5440	SNAPC2,POLR2L,BRF2,GTF3C4,NFIB,POLR3B,GTF3C2,POLR3K,POLR3G,GTF3C3,SNAPC5,GTF3A,NFIX,ZNF143,GTF3C1,POLR3E,CRCP,GTF3C6,SNAPC1,POLR2E,POLR3H,POLR3GL,POLR3A,SNAPC3,POLR3C,GTF3C5,POLR1C,NFIA,POLR3D,NFIC,SSB,POLR1D,POU2F1,POLR2K
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	0.882531744522552	-0.12496051969126	68	57	0.00630949745406243	9034	10285	5707,25906,6233,5718,5701,5717,5706,5715,5682,7324,11065,5694,9861,5708,5711,143471,5710,51529,7979,7316,996,5713,23198,9491,10197,5700,5692,5699,7311,5684,122706,7321,5695,991,8697,5691,5714,9232,51433,5720,10213,5696,5698,5704,5685,5719,5687,7314,119504,5702,5686,5690,51434,64682,5693,10393,29945	PSMD1,ANAPC15,RPS27A,PSMD12,PSMC2,PSMD11,PSMC6,PSMD9,PSMA1,UBE2E1,UBE2C,PSMB6,PSMD6,PSMD2,PSMD5,PSMA8,PSMD4,ANAPC11,SEM1,UBC,CDC27,PSMD7,PSME4,PSMF1,PSME3,PSMC1,PSMB4,PSMB10,UBA52,PSMA3,PSMB11,UBE2D1,PSMB7,CDC20,CDC23,PSMB3,PSMD8,PTTG1,ANAPC5,PSME1,PSMD14,PSMB8,PSMB9,PSMC4,PSMA4,PSMD13,PSMA6,UBB,ANAPC16,PSMC3,PSMA5,PSMB2,ANAPC7,ANAPC1,PSMB5,ANAPC10,ANAPC4
R-HSA-6803529	FGFR2 alternative splicing	0.883625081446254	-0.123722422318152	28	23	0.00254593756918309	9034	10285	7073,5441,5431,7072,22916,2963,4686,5434,3187,2962,3185,80004,4670,3178,54845,23543,100616459,5725,5430,5439,5432,5433,5440	TIAL1,POLR2L,POLR2B,TIA1,NCBP2,GTF2F2,NCBP1,POLR2E,HNRNPH1,GTF2F1,HNRNPF,ESRP2,HNRNPM,HNRNPA1,ESRP1,RBFOX2,MIR4745,PTBP1,POLR2A,POLR2J,POLR2C,POLR2D,POLR2K
R-HSA-437239	Recycling pathway of L1	0.883625081446254	-0.123722422318152	28	23	0.00254593756918309	9034	10285	6456,5962,163,161,26052,1213,285643,5594,1175,6195,1759,8650,160,1211,9252,6196,57698,1173,1785,1808,6714,7430,8986	SH3GL2,RDX,AP2B1,AP2A2,DNM3,CLTC,KIF4B,MAPK1,AP2S1,RPS6KA1,DNM1,NUMB,AP2A1,CLTA,RPS6KA5,RPS6KA2,SHTN1,AP2M1,DNM2,DPYSL2,SRC,EZR,RPS6KA4
R-HSA-5683678	Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	6439,653509,729238,6441	SFTPB,SFTPA1,SFTPA2,SFTPD
R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	8454,6500,9978,55294	CUL1,SKP1,RBX1,FBXW7
R-HSA-2644605	FBXW7 Mutants and NOTCH1 in Cancer	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	9978,55294,6500,8454	RBX1,FBXW7,SKP1,CUL1
R-HSA-77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	6296,142827,35,3033	ACSM3,ACSM6,ACADS,HADH
R-HSA-111463	SMAC binds to IAPs	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	836,842,56616,840	CASP3,CASP9,DIABLO,CASP7
R-HSA-6785470	tRNA processing in the mitochondrion	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	51095,9692,54931,60528	TRNT1,PRORP,TRMT10C,ELAC2
R-HSA-1614517	Sulfide oxidation to sulfate	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	7263,1468,6821,58472	TST,SLC25A10,SUOX,SQOR
R-HSA-427652	Sodium-coupled phosphate cotransporters	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	10568,6575,6569,6574	SLC34A2,SLC20A2,SLC34A1,SLC20A1
R-HSA-3642278	Loss of Function of TGFBR2 in Cancer	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	7048,7046,7040,2280	TGFBR2,TGFBR1,TGFB1,FKBP1A
R-HSA-140834	Extrinsic Pathway of Fibrin Clot Formation	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	2152,2159,2155,7035	F3,F10,F7,TFPI
R-HSA-167826	The fatty acid cycling model	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	7351,9481,7352,7350	UCP2,SLC25A27,UCP3,UCP1
R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	3033,35,3032,3030	HADH,ACADS,HADHB,HADHA
R-HSA-8869496	TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	3329,4869,7020,4605	HSPD1,NPM1,TFAP2A,MYBL2
R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	3030,3032,34,3033	HADHA,HADHB,ACADM,HADH
R-HSA-167827	The proton buffering model	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	7352,7350,7351,9481	UCP3,UCP1,UCP2,SLC25A27
R-HSA-3656535	TGFBR1 LBD Mutants in Cancer	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	7048,7046,7040,2280	TGFBR2,TGFBR1,TGFB1,FKBP1A
R-HSA-3645790	TGFBR2 Kinase Domain Mutants in Cancer	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	2280,7040,7046,7048	FKBP1A,TGFB1,TGFBR1,TGFBR2
R-HSA-166187	Mitochondrial Uncoupling Proteins	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	7352,7350,7351,9481	UCP3,UCP1,UCP2,SLC25A27
R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	3032,3030,3033,34	HADHB,HADHA,HADH,ACADM
R-HSA-8866376	Reelin signalling pathway	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	7436,1600,2534,5649	VLDLR,DAB1,FYN,RELN
R-HSA-1306955	GRB7 events in ERBB2 signaling	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	2064,9542,2065,3084	ERBB2,NRG2,ERBB3,NRG1
R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	3030,33,3032,3033	HADHA,ACADL,HADHB,HADH
R-HSA-8866423	VLDL biosynthesis	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	4547,341,338,5034	MTTP,APOC1,APOB,P4HB
R-HSA-433137	Sodium-coupled sulphate, di- and tri-carboxylate transporters	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	284111,6561,26266,64849	SLC13A5,SLC13A1,SLC13A4,SLC13A3
R-HSA-2855086	Ficolins bind to repetitive carbohydrate structures on the target cell surface	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	5648,10747,2219,2220	MASP1,MASP2,FCN1,FCN2
R-HSA-209931	Serotonin and melatonin biosynthesis	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	121278,15,1644,7166	TPH2,AANAT,DDC,TPH1
R-HSA-111469	SMAC-mediated apoptotic response	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	56616,840,842,836	DIABLO,CASP7,CASP9,CASP3
R-HSA-111464	SMAC-mediated dissociation of IAP:caspase complexes	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	836,842,56616,840	CASP3,CASP9,DIABLO,CASP7
R-HSA-163358	PKA-mediated phosphorylation of key metabolic factors	0.884908062899493	-0.122271523099882	5	4	0.000442771751162276	9034	10285	5566,5567,51085,5568	PRKACA,PRKACB,MLXIPL,PRKACG
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	0.886163518255598	-0.120853787555199	54	45	0.0049811822005756	9034	10285	5434,902,10987,6233,7507,3150,9716,5441,7874,1161,7316,5440,9978,5432,2074,5439,8451,10450,50813,1022,404672,2033,7311,9318,51138,57461,57654,5431,4331,2068,91603,5433,10920,2968,5430,6917,7314,2873,2967,1642,2965,64708,8533,2071,100302237	POLR2E,CCNH,COPS5,RPS27A,XPA,HMGN1,AQR,POLR2L,USP7,ERCC8,UBC,POLR2K,RBX1,POLR2C,ERCC6,POLR2J,CUL4A,PPIE,COPS7A,CDK7,GTF2H5,EP300,UBA52,COPS2,COPS4,ISY1,UVSSA,POLR2B,MNAT1,ERCC2,ZNF830,POLR2D,COPS8,GTF2H4,POLR2A,TCEA1,UBB,GPS1,GTF2H3,DDB1,GTF2H1,COPS7B,COPS3,ERCC3,MIR1281
R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	0.886506960338401	-0.120466302017139	124	105	0.0116227584680097	9034	10285	3802,11314,54210,100131439,7412,3383,56253,567,919,917,930,3133,3820,9436,933,2213,916,114836,8778,146722,114132,146894,9437,7087,10859,27181,3904,10219,11006,911,2214,27036,3695,10666,3676,3903,9976,79465,5819,4345,999,27180,3384,945,3811,117157,3805,8174,6402,3134,51348,259197,100528032,3106,342510,975,89858,3812,5817,915,11126,4277,3107,285852,3105,1525,11027,3689,3821,10871,3135,100507436,3386,10225,135250,6614,926,3804,912,374383,120425,3385,3136,29121,124599,11024,3824,909,131450,3683,910,7305,89790,958,718,946,8519,947,80329,22914,3688,79865,2209,57823,644076	KIR2DL1,CD300A,TREM1,CD300LD,VCAM1,ICAM1,CRTAM,B2M,CD247,CD3G,CD19,HLA-E,KLRB1,NCR2,CD22,FCGR2B,CD3E,SLAMF6,SIGLEC5,CD300LF,SIGLEC11,CD300LG,NCR1,ICAM5,LILRB1,SIGLEC8,LAIR2,KLRG1,LILRB4,CD1C,FCGR3A,SIGLEC7,ITGB7,CD226,ITGA4,LAIR1,CLEC2B,ULBP3,NECTIN2,CD200,CDH1,SIGLEC9,ICAM2,CD33,KIR3DL1,SH2D1B,KIR2DL4,MADCAM1,SELL,HLA-F,KLRF1,NCR3,KLRC4-KLRK1,HLA-B,CD300E,CD81,SIGLEC12,KIR3DL2,PVR,CD3D,CD160,MICB,HLA-C,TREML4,HLA-A,CXADR,LILRA2,ITGB2,KLRC1,CD300C,HLA-G,MICA,ICAM4,CD96,RAET1E,SIGLEC1,CD8B,KIR2DL3,CD1D,NCR3LG1,JAML,ICAM3,HLA-H,CLEC2D,CD300LB,LILRA1,KLRD1,CD1A,CD200R1,ITGAL,CD1B,TYROBP,SIGLEC10,CD40,C3,SIGLEC6,IFITM1,CD34,ULBP1,KLRK1,ITGB1,TREML2,FCGR1A,SLAMF7,GLYCAM1
R-HSA-427601	Multifunctional anion exchangers	0.887927747395527	-0.1188649048459	10	8	0.000885543502324552	9034	10285	5172,1836,159963,115111,284129,10861,115019,1811	SLC26A4,SLC26A2,SLC5A12,SLC26A7,SLC26A11,SLC26A1,SLC26A9,SLC26A3
R-HSA-8875656	MET receptor recycling	0.887927747395527	-0.1188649048459	10	8	0.000885543502324552	9034	10285	1398,382,4233,23163,3082,2885,5867,2549	CRK,ARF6,MET,GGA3,HGF,GRB2,RAB4A,GAB1
R-HSA-5687613	Diseases associated with surfactant metabolism	0.887927747395527	-0.1188649048459	10	8	0.000885543502324552	9034	10285	7270,29080,1439,729238,653509,6441,253970,6439	TTF1,CCDC59,CSF2RB,SFTPA2,SFTPA1,SFTPD,SFTA3,SFTPB
R-HSA-159740	Gamma-carboxylation of protein precursors	0.887927747395527	-0.1188649048459	10	8	0.000885543502324552	9034	10285	2677,2147,5627,5624,8858,632,2159,2155	GGCX,F2,PROS1,PROC,PROZ,BGLAP,F10,F7
R-HSA-430116	GP1b-IX-V activation signalling	0.887927747395527	-0.1188649048459	10	8	0.000885543502324552	9034	10285	2815,7534,7450,2811,2814,6714,5295,5894	GP9,YWHAZ,VWF,GP1BA,GP5,SRC,PIK3R1,RAF1
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	0.887927747395527	-0.1188649048459	10	8	0.000885543502324552	9034	10285	64768,9677,11163,11165,117283,9807,3705,23262	IPPK,PPIP5K1,NUDT4,NUDT3,IP6K3,IP6K1,ITPK1,PPIP5K2
R-HSA-159782	Removal of aminoterminal propeptides from gamma-carboxylated proteins	0.887927747395527	-0.1188649048459	10	8	0.000885543502324552	9034	10285	2147,5045,5627,5624,2159,8858,632,2155	F2,FURIN,PROS1,PROC,F10,PROZ,BGLAP,F7
R-HSA-8849932	SALM protein interactions at the synapses	0.89738893347239	-0.108265917283185	21	17	0.00188177994243967	9034	10285	2905,10211,2890,5802,2893,79414,10313,78999,2319,2906,1742,5792,57497,2904,2903,1739,5789	GRIN2C,FLOT1,GRIA1,PTPRS,GRIA4,LRFN3,RTN3,LRFN4,FLOT2,GRIN2D,DLG4,PTPRF,LRFN2,GRIN2B,GRIN2A,DLG1,PTPRD
R-HSA-977225	Amyloid fiber formation	0.897975939657868	-0.107612004292927	101	85	0.00940889971219836	9034	10285	1471,8349,7045,128312,8362,3012,8354,23062,337,335,796,3021,3020,9627,8364,8344,6288,3630,723790,6406,3375,3339,567,9246,8335,4069,4240,8359,6653,8352,7314,2934,8363,8340,4878,8343,8970,8355,8339,8357,8360,5071,23621,5617,653604,8968,325,26088,6622,8358,793,9445,3013,6233,3015,351,8368,3017,6477,8334,8346,8348,8366,7311,2243,121504,7276,7316,8361,23163,8345,8353,8347,8370,8341,54959,8350,8367,126961,3018,8365,6478,4057,9027,5045	CST3,H2BC21,TGFBI,H2BC26,H4C12,H2AC8,H3C11,GGA2,APOA4,APOA1,CALCA,H3-3B,H3-3A,SNCAIP,H4C3,H2BC6,SAA1,INS,H2AC19,SEMG1,IAPP,HSPG2,B2M,UBE2L6,H2AC4,LYZ,MFGE8,H4C1,SORL1,H3C3,UBB,GSN,H4C11,H2BC13,NPPA,H2BC7,H2BC11,H3C8,H2BC8,H3C10,H4C4,PRKN,BACE1,PRL,H3C13,H3C7,APCS,GGA1,SNCA,H3C2,CALB1,ITM2B,H2AC7,RPS27A,H2AZ1,APP,H4C13,H2BC5,SIAH1,H2AC6,H2BC10,H2BC17,H4C2,UBA52,FGA,H4C16,TTR,UBC,H4C6,GGA3,H2BC9,H3C6,H2BC4,H4C14,H2BC15,ODAM,H3C1,H4C5,H3C14,H2BC3,H4C8,SIAH2,LTF,NAT8,FURIN
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	0.89868654996999	-0.106820970525284	27	22	0.00243524463139252	9034	10285	2962,8732,5434,902,2963,5431,4331,5441,2068,5440,5433,5432,2968,5430,5439,2967,1022,2965,2071,404672,8731,6829	GTF2F1,RNGTT,POLR2E,CCNH,GTF2F2,POLR2B,MNAT1,POLR2L,ERCC2,POLR2K,POLR2D,POLR2C,GTF2H4,POLR2A,POLR2J,GTF2H3,CDK7,GTF2H1,ERCC3,GTF2H5,RNMT,SUPT5H
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	0.89868654996999	-0.106820970525284	27	22	0.00243524463139252	9034	10285	2967,1022,2965,2071,8731,404672,6829,5440,5433,5430,5439,2968,5432,5431,4331,5441,2068,8732,2962,902,5434,2963	GTF2H3,CDK7,GTF2H1,ERCC3,RNMT,GTF2H5,SUPT5H,POLR2K,POLR2D,POLR2A,POLR2J,GTF2H4,POLR2C,POLR2B,MNAT1,POLR2L,ERCC2,RNGTT,GTF2F1,CCNH,POLR2E,GTF2F2
R-HSA-6807505	RNA polymerase II transcribes snRNA genes	0.899400975847965	-0.10602631964727	73	61	0.00675226920522471	9034	10285	55756,5452,79664,79871,2958,129685,22916,6884,5431,2963,26512,92105,10302,8178,2957,55174,2960,4686,84524,23248,2961,6882,80237,6619,25896,57117,5430,55656,26173,22936,6667,55197,5433,8812,5441,6618,904,65123,64859,58490,57508,7702,23379,80789,2962,5434,6617,6880,81556,54973,2959,51808,1022,51593,5432,5439,55726,6877,5440,905,5451	INTS9,POU2F2,ICE2,RPAP2,GTF2A2,TAF8,NCBP2,TAF13,POLR2B,GTF2F2,INTS6,INTS4,SNAPC5,ELL,GTF2A1,INTS10,GTF2E1,NCBP1,ZC3H8,RPRD2,GTF2E2,TAF11,ELL3,SNAPC3,INTS7,INTS12,POLR2A,INTS8,INTS1,ELL2,SP1,RPRD1A,POLR2D,CCNK,POLR2L,SNAPC2,CCNT1,INTS3,NABP1,RPRD1B,INTS2,ZNF143,ICE1,INTS5,GTF2F1,POLR2E,SNAPC1,TAF9,INTS14,INTS11,GTF2B,PHAX,CDK7,SRRT,POLR2C,POLR2J,INTS13,TAF5,POLR2K,CCNT2,POU2F1
R-HSA-2691230	Signaling by NOTCH1 HD Domain Mutants in Cancer	0.900468337470538	-0.104840276038663	15	12	0.00132831525348683	9034	10285	6868,54567,3714,7316,142678,54492,102,9148,6233,7314,7311,182	ADAM17,DLL4,JAG2,UBC,MIB2,NEURL1B,ADAM10,NEURL1,RPS27A,UBB,UBA52,JAG1
R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	0.900468337470538	-0.104840276038663	15	12	0.00132831525348683	9034	10285	51,54898,3295,3992,64834,9415,2180,6342,60481,83401,10005,30	ACOX1,ELOVL2,HSD17B4,FADS1,ELOVL1,FADS2,ACSL1,SCP2,ELOVL5,ELOVL3,ACOT8,ACAA1
R-HSA-68884	Mitotic Telophase/Cytokinesis	0.900468337470538	-0.104840276038663	15	12	0.00132831525348683	9034	10285	5347,9493,23383,10274,9126,10112,23047,23244,5885,25836,10726,23063	PLK1,KIF23,MAU2,STAG1,SMC3,KIF20A,PDS5B,PDS5A,RAD21,NIPBL,NUDC,WAPL
R-HSA-2046104	alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	0.900468337470538	-0.104840276038663	15	12	0.00132831525348683	9034	10285	10005,30,51,83401,3295,54898,64834,9415,3992,2180,6342,60481	ACOT8,ACAA1,ACOX1,ELOVL3,HSD17B4,ELOVL2,ELOVL1,FADS2,FADS1,ACSL1,SCP2,ELOVL5
R-HSA-391903	Eicosanoid ligand-binding receptors	0.900468337470538	-0.104840276038663	15	12	0.00132831525348683	9034	10285	5731,165140,5729,5737,1241,57105,5733,5734,5739,5732,11251,6915	PTGER1,OXER1,PTGDR,PTGFR,LTB4R,CYSLTR2,PTGER3,PTGER4,PTGIR,PTGER2,PTGDR2,TBXA2R
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	0.900468337470538	-0.104840276038663	15	12	0.00132831525348683	9034	10285	7311,3714,7314,6233,102,9148,54492,182,54567,6868,142678,7316	UBA52,JAG2,UBB,RPS27A,ADAM10,NEURL1,NEURL1B,JAG1,DLL4,ADAM17,MIB2,UBC
R-HSA-5625740	RHO GTPases activate PKNs	0.905038157483813	-0.0997781732055043	93	78	0.00863404914766438	9034	10285	8335,8352,8359,103910,387,389,5170,79784,7534,8344,723790,3020,8364,4660,5500,388,55766,10971,7532,3021,4628,3012,8354,5879,128312,8362,354,4627,8349,94239,8370,8341,10499,8350,8367,8365,126961,3018,8361,4629,8353,8345,8347,8348,94274,121504,8366,2810,8368,3015,3017,7531,23028,29941,8334,8346,3013,5586,8968,653604,4659,4637,7533,8358,23081,8355,8970,8343,8357,8339,7529,5585,8360,10398,995,8363,3817,8340	H2AC4,H3C3,H4C1,MYL12B,RHOA,RHOC,PDPK1,MYH14,YWHAZ,H2BC6,H2AC19,H3-3A,H4C3,PPP1R12B,PPP1CB,RHOB,H2AJ,YWHAQ,YWHAG,H3-3B,MYH10,H2AC8,H3C11,RAC1,H2BC26,H4C12,KLK3,MYH9,H2BC21,H2AZ2,H4C14,H2BC15,NCOA2,H3C1,H4C5,H4C8,H3C14,H2BC3,H4C6,MYH11,H3C6,H2BC9,H2BC4,H2BC17,PPP1R14A,H4C16,H4C2,SFN,H4C13,H2AZ1,H2BC5,YWHAE,KDM1A,PKN3,H2AC6,H2BC10,H2AC7,PKN2,H3C7,H3C13,PPP1R12A,MYL6,YWHAH,H3C2,KDM4C,H3C8,H2BC11,H2BC7,H3C10,H2BC8,YWHAB,PKN1,H4C4,MYL9,CDC25C,H4C11,KLK2,H2BC13
R-HSA-163200	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	0.911608519580031	-0.0925446359104981	113	95	0.0105158290901041	9034	10285	84987,7385,4709,137682,27109,516,4728,4712,2110,55967,7386,522,54205,374291,518,1353,6389,51300,80224,4696,7351,1351,51295,4704,4723,2108,4695,4697,9167,517,6391,10975,4724,4731,498,4710,9481,4715,4729,4717,10131,4708,4716,80219,10128,1329,93058,4726,514,4702,1327,7381,4725,4719,1350,29796,7350,1345,4720,1340,4698,29078,6392,116228,4714,515,91942,51241,10632,4700,506,9377,513,100616403,1337,51079,7352,285521,7384,4722,4706,51103,55471,4711,79133,4705,4707,28976,539,6390,6341,126328,10476,509,4718	COX14,UQCRC2,NDUFB3,NDUFAF6,DMAC2L,ATP5MC1,NDUFS8,NDUFB6,ETFDH,NDUFA12,UQCRFS1,ATP5PF,CYCS,NDUFS7,ATP5MC3,COX11,SDHA,TIMMDC1,NUBPL,NDUFA3,UCP2,COX8A,ECSIT,NDUFA9,NDUFV1,ETFA,NDUFA2,NDUFA4,COX7A2L,ATP5MC2,SDHC,UQCR11,NDUFS4,NDUFV3,ATP5F1A,NDUFB4,SLC25A27,NDUFB9,NDUFV2,NDUFC1,TRAP1,NDUFB2,NDUFB10,COQ10B,LRPPRC,COX5B,COQ10A,NDUFS6,ATP5F1E,NDUFA8,COX4I1,UQCRB,NDUFS5,NDUFS1,COX7C,UQCR10,UCP1,COX6C,NDUFS2,COX6B1,NDUFA5,NDUFAF4,SDHD,COX20,NDUFB8,ATP5PB,NDUFAF2,COX16,ATP5MG,NDUFA6,ATP5F1B,COX5A,ATP5F1D,MIR4691,COX6A1,NDUFA13,UCP3,COX18,UQCRC1,NDUFS3,NDUFAB1,NDUFAF1,NDUFAF7,NDUFB5,NDUFAF5,NDUFA10,NDUFB1,ACAD9,ATP5PO,SDHB,SCO1,NDUFA11,ATP5PD,ATP5F1C,NDUFC2
R-HSA-611105	Respiratory electron transport	0.911933040506171	-0.0921887121008414	92	77	0.00852335620987381	9034	10285	285521,7384,4710,51079,1337,10975,4731,4724,100616403,9377,4700,51241,6391,6341,126328,6390,93058,4718,4716,4707,4705,80219,10128,1329,28976,55471,79133,4708,4711,4706,51103,4717,4722,4715,4729,10131,1353,1345,6389,4725,7386,4719,55967,4712,2110,374291,54205,29796,1350,4728,7381,4709,4702,7385,84987,4726,137682,1327,6392,9167,91942,4714,116228,29078,4697,4695,1351,4698,1340,2108,4723,4704,51295,4720,4696,80224,51300	COX18,UQCRC1,NDUFB4,NDUFA13,COX6A1,UQCR11,NDUFV3,NDUFS4,MIR4691,COX5A,NDUFA6,COX16,SDHC,SCO1,NDUFA11,SDHB,COQ10A,NDUFC2,NDUFB10,NDUFB1,NDUFA10,COQ10B,LRPPRC,COX5B,ACAD9,NDUFAF7,NDUFAF5,NDUFB2,NDUFB5,NDUFAB1,NDUFAF1,NDUFC1,NDUFS3,NDUFB9,NDUFV2,TRAP1,COX11,COX6C,SDHA,NDUFS5,UQCRFS1,NDUFS1,NDUFA12,NDUFB6,ETFDH,NDUFS7,CYCS,UQCR10,COX7C,NDUFS8,UQCRB,NDUFB3,NDUFA8,UQCRC2,COX14,NDUFS6,NDUFAF6,COX4I1,SDHD,COX7A2L,NDUFAF2,NDUFB8,COX20,NDUFAF4,NDUFA4,NDUFA2,COX8A,NDUFA5,COX6B1,ETFA,NDUFV1,NDUFA9,ECSIT,NDUFS2,NDUFA3,NUBPL,TIMMDC1
R-HSA-975298	Ligand-gated ion channel transport	0.912654078251626	-0.0913983549010386	26	21	0.00232455169360195	9034	10285	170572,2561,2554,2558,200959,2570,2743,9177,2559,2567,285242,200909,3359,8001,2555,2741,2557,2562,2569,2566,2560	HTR3C,GABRB2,GABRA1,GABRA5,GABRR3,GABRR2,GLRB,HTR3B,GABRA6,GABRG3,HTR3E,HTR3D,HTR3A,GLRA3,GABRA2,GLRA1,GABRA4,GABRB3,GABRR1,GABRG2,GABRB1
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	0.913569622106253	-0.0903956913925658	20	16	0.0017710870046491	9034	10285	8767,7335,5608,7189,10454,7867,23118,5606,5600,9261,1432,6885,7334,10392,64127,3656	RIPK2,UBE2V1,MAP2K6,TRAF6,TAB1,MAPKAPK3,TAB2,MAP2K3,MAPK11,MAPKAPK2,MAPK14,MAP3K7,UBE2N,NOD1,NOD2,IRAK2
R-HSA-189085	Digestion of dietary carbohydrate	0.914051819783176	-0.0898680135298965	9	7	0.000774850564533983	9034	10285	279,276,11181,6476,3938,8972,280	AMY2A,AMY1A,TREH,SI,LCT,MGAM,AMY2B
R-HSA-419771	Opsins	0.914051819783176	-0.0898680135298965	9	7	0.000774850564533983	9034	10285	611,23596,10692,6010,94233,221391,5995	OPN1SW,OPN3,RRH,RHO,OPN4,OPN5,RGR
R-HSA-166665	Terminal pathway of complement	0.914051819783176	-0.0898680135298965	9	7	0.000774850564533983	9034	10285	730,731,1191,735,732,727,729	C7,C8A,CLU,C9,C8B,C5,C6
R-HSA-2453864	Retinoid cycle disease events	0.914051819783176	-0.0898680135298965	9	7	0.000774850564533983	9034	10285	7276,5947,6017,5950,222236,611,64220	TTR,RBP1,RLBP1,RBP4,NAPEPLD,OPN1SW,STRA6
R-HSA-425986	Sodium/Proton exchangers	0.914051819783176	-0.0898680135298965	9	7	0.000774850564533983	9034	10285	389015,285195,23315,6548,6550,6549,6553	SLC9A4,SLC9A9,SLC9A8,SLC9A1,SLC9A3,SLC9A2,SLC9A5
R-HSA-2474795	Diseases associated with visual transduction	0.914051819783176	-0.0898680135298965	9	7	0.000774850564533983	9034	10285	6017,5947,7276,64220,611,222236,5950	RLBP1,RBP1,TTR,STRA6,OPN1SW,NAPEPLD,RBP4
R-HSA-159763	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	0.914051819783176	-0.0898680135298965	9	7	0.000774850564533983	9034	10285	2159,632,8858,5627,2155,2147,5624	F10,BGLAP,PROZ,PROS1,F7,F2,PROC
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	0.917488335210859	-0.0861154128008699	64	53	0.00586672570290016	9034	10285	10213,5696,5720,5704,5698,5695,7321,5714,51433,5691,8697,51434,5690,5686,5702,29945,5693,64682,10393,7314,51343,5687,5719,5685,119504,11065,7324,5715,5682,5717,5706,5711,5708,5694,9861,6233,25906,5707,5701,5718,7311,5692,5699,9491,10197,5700,5684,5710,5713,996,7979,7316,51529	PSMD14,PSMB8,PSME1,PSMC4,PSMB9,PSMB7,UBE2D1,PSMD8,ANAPC5,PSMB3,CDC23,ANAPC7,PSMB2,PSMA5,PSMC3,ANAPC4,PSMB5,ANAPC1,ANAPC10,UBB,FZR1,PSMA6,PSMD13,PSMA4,ANAPC16,UBE2C,UBE2E1,PSMD9,PSMA1,PSMD11,PSMC6,PSMD5,PSMD2,PSMB6,PSMD6,RPS27A,ANAPC15,PSMD1,PSMC2,PSMD12,UBA52,PSMB4,PSMB10,PSMF1,PSME3,PSMC1,PSMA3,PSMD4,PSMD7,CDC27,SEM1,UBC,ANAPC11
R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex	0.918499341215659	-0.0850140915665615	91	76	0.00841266327208324	9034	10285	8344,100302237,723790,3020,8364,8313,5929,8335,7091,8352,8359,90780,51176,8290,128312,8362,7088,7090,3065,8349,8295,55766,4221,3021,4609,3012,8354,1387,10524,2033,8348,121504,9070,8366,6932,26108,8368,3015,7089,3017,8334,8346,7015,94239,8341,8370,8350,8367,79577,8365,1499,3018,126961,6597,8361,283149,607,8353,8345,8347,83439,8355,8343,8970,8357,8339,8360,6934,123169,8363,8340,3013,8968,653604,8607,8358	H2BC6,MIR1281,H2AC19,H3-3A,H4C3,AXIN2,RBBP5,H2AC4,TLE4,H3C3,H4C1,PYGO2,LEF1,H3-4,H2BC26,H4C12,TLE1,TLE3,HDAC1,H2BC21,TRRAP,H2AJ,MEN1,H3-3B,MYC,H2AC8,H3C11,CREBBP,KAT5,EP300,H2BC17,H4C16,ASH2L,H4C2,TCF7,PYGO1,H4C13,H2AZ1,TLE2,H2BC5,H2AC6,H2BC10,TERT,H2AZ2,H2BC15,H4C14,H3C1,H4C5,CDC73,H4C8,CTNNB1,H2BC3,H3C14,SMARCA4,H4C6,BCL9L,BCL9,H3C6,H2BC9,H2BC4,TCF7L1,H3C8,H2BC7,H2BC11,H3C10,H2BC8,H4C4,TCF7L2,LEO1,H4C11,H2BC13,H2AC7,H3C7,H3C13,RUVBL1,H3C2
R-HSA-1483213	Synthesis of PE	0.919586801367276	-0.0838308387762794	14	11	0.00121762231569626	9034	10285	55224,64850,1119,10390,64900,162466,9663,23761,55500,23175,5833	ETNK2,ETNPPL,CHKA,CEPT1,LPIN3,PHOSPHO1,LPIN2,PISD,ETNK1,LPIN1,PCYT2
R-HSA-1679131	Trafficking and processing of endosomal TLR	0.919586801367276	-0.0838308387762794	14	11	0.00121762231569626	9034	10285	1508,1514,1513,81622,7098,54106,10695,100500842,1515,1520,5641	CTSB,CTSL,CTSK,UNC93B1,TLR3,TLR9,CNPY3,MIR3652,CTSV,CTSS,LGMN
R-HSA-2024101	CS/DS degradation	0.919586801367276	-0.0838308387762794	14	11	0.00121762231569626	9034	10285	63827,8372,1463,1464,1634,411,3074,3373,10675,1462,3425	BCAN,HYAL3,NCAN,CSPG4,DCN,ARSB,HEXB,HYAL1,CSPG5,VCAN,IDUA
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	0.920454874957564	-0.0828873018272442	57	47	0.00520256807615674	9034	10285	5695,5691,5714,3312,5720,3184,10213,5696,5698,26986,5704,5687,5685,5719,7314,5686,1981,5702,5690,5693,5707,6233,5701,5718,5715,5682,5717,5706,5694,9861,5711,5708,143471,5710,7979,7316,23198,5713,9491,10197,5700,7311,5692,5699,122706,5684,3315	PSMB7,PSMB3,PSMD8,HSPA8,PSME1,HNRNPD,PSMD14,PSMB8,PSMB9,PABPC1,PSMC4,PSMA6,PSMA4,PSMD13,UBB,PSMA5,EIF4G1,PSMC3,PSMB2,PSMB5,PSMD1,RPS27A,PSMC2,PSMD12,PSMD9,PSMA1,PSMD11,PSMC6,PSMB6,PSMD6,PSMD5,PSMD2,PSMA8,PSMD4,SEM1,UBC,PSME4,PSMD7,PSMF1,PSME3,PSMC1,UBA52,PSMB4,PSMB10,PSMB11,PSMA3,HSPB1
R-HSA-6807062	Cholesterol biosynthesis via lathosterol	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	1718,1717,6309	DHCR24,DHCR7,SC5D
R-HSA-1369007	Mitochondrial ABC transporters	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	23456,11194,10058	ABCB10,ABCB8,ABCB6
R-HSA-379401	Dopamine clearance from the synaptic cleft	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	100616414,6531,1312	MIR4761,SLC6A3,COMT
R-HSA-75108	Activation, myristolyation of BID and translocation to mitochondria	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	841,4836,3002	CASP8,NMT1,GZMB
R-HSA-6807047	Cholesterol biosynthesis via desmosterol	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	6309,1717,1718	SC5D,DHCR7,DHCR24
R-HSA-5619099	Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	551,553,552	AVP,AVPR1B,AVPR1A
R-HSA-1296061	HCN channels	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	10021,610,348980	HCN4,HCN2,HCN1
R-HSA-110381	Resolution of AP sites via the single-nucleotide replacement pathway	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	5423,7515,3980	POLB,XRCC1,LIG3
R-HSA-399710	Activation of AMPA receptors	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	2890,2891,2893	GRIA1,GRIA2,GRIA4
R-HSA-3878781	Glycogen storage disease type IV (GBE1)	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	2998,2997,2992	GYS2,GYS1,GYG1
R-HSA-5083630	Defective LFNG causes SCDO3	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	4855,4854,4853	NOTCH4,NOTCH3,NOTCH2
R-HSA-8847453	Synthesis of PIPs in the nucleus	0.925006198584334	-0.0779548403199115	4	3	0.000332078813371707	9034	10285	8396,79837,5305	PIP4K2B,PIP4K2C,PIP4K2A
R-HSA-167242	Abortive elongation of HIV-1 transcript in the absence of Tat	0.925493722249208	-0.0774279300826673	25	20	0.00221385875581138	9034	10285	51497,5434,5433,4686,2962,100302242,5440,2963,5432,5430,5439,6827,22916,7936,5431,5441,7469,100126332,6829,9150	NELFCD,POLR2E,POLR2D,NCBP1,GTF2F1,MIR1236,POLR2K,GTF2F2,POLR2C,POLR2A,POLR2J,SUPT4H1,NCBP2,NELFE,POLR2B,POLR2L,NELFA,MIR943,SUPT5H,CTDP1
R-HSA-5663205	Infectious disease	0.927063067379006	-0.0757336818804192	388	332	0.0367500553464689	9034	10285	6883,6124,3837,5478,9045,7936,6457,10053,2959,9883,8021,9491,6159,10197,5440,6138,200916,6923,7251,7316,821,164,9631,5045,5610,8065,79849,162699,118429,8945,6921,6206,808,84168,5608,6873,6749,8812,5715,5682,1173,5701,6881,2962,9525,902,57122,1234,6230,6205,51652,6827,2965,6202,6874,6165,5690,5609,5686,2071,1174,9818,163,2547,100506888,6166,25873,5430,4836,8907,8815,5901,5685,6884,5704,6123,3326,23511,22916,23279,2958,2068,9899,5903,8732,4686,6924,100302168,1839,2237,4869,6139,3840,23225,805,1022,5684,9636,7311,6224,1500,5699,91782,8731,6137,5713,811,7175,129401,9978,1175,6164,51510,6843,1499,6875,5439,23521,25978,3838,5711,5902,6194,11168,130340,6189,7469,6122,5706,7518,55690,6201,79902,6130,9397,2885,6161,2060,6188,2926,6416,3981,9150,6829,5702,6882,2961,5905,7314,6125,7040,55706,867,3932,4331,138474,5698,6223,7520,6714,22987,116832,83860,10213,6204,100101267,23165,51121,11224,5714,3839,51534,2957,6844,928,6157,9844,2963,122706,51606,6235,162,6455,5692,7296,291,23198,4928,3836,905,6456,7979,4057,6857,51224,920,8086,5432,6144,143471,5710,6154,5708,6616,9861,999,10762,23636,5717,904,6129,6133,55746,6207,8106,2967,3320,6128,27183,11198,6167,3921,801,567,919,1794,6227,6917,11097,5687,10254,140801,5604,6500,79720,160,3159,6879,940,5696,6176,5879,2960,10015,8178,6232,5695,402569,6160,6143,6175,9972,7852,6231,8027,128866,1938,2984,100126332,4927,6135,6152,1104,5700,6880,404672,6210,92421,81929,6877,79643,127833,60489,6136,4233,348995,4736,375,5611,5694,6217,6229,6208,5606,79872,5441,100302242,5718,6142,5434,5605,6233,6169,23327,5707,112755,79023,2534,5693,6209,1211,6228,137492,6146,5433,9146,6168,6181,3105,51497,6234,51065,2968,9688,5719,5062,5431,55048,5720,6156,926,10898,3843,9349,7514,5691,1213,161,53371,6155,3978,9900	TAF12,RPL4,KPNB1,PPIA,RPL14,NELFE,SH3GL3,AP1M2,GTF2B,POM121,NUP214,PSMF1,RPL29,PSME3,POLR2K,RPL15,RPL22L1,ELOB,TSG101,UBC,CANX,AP1G1,NUP155,FURIN,EIF2AK2,CUL5,NHERF4,ELOA3P,ANTXR2,BTRC,ELOC,RPS12,CALM3,ANTXR1,MAP2K6,TAF2,SSRP1,CCNK,PSMD9,PSMA1,AP2M1,PSMC2,TAF10,GTF2F1,VPS4B,CCNH,NUP107,CCR5,RPS25,RPS11,CHMP3,SUPT4H1,GTF2H1,RPS8,TAF4,RPL35A,PSMB2,MAP2K7,PSMA5,ERCC3,AP1S1,NUP58,AP2B1,XRCC6,ELOA3DP,RPL36AL,RPL36,POLR2A,NMT1,AP1M1,BANF1,RAN,PSMA4,TAF13,PSMC4,RPL3L,HSP90AB1,NUP188,NCBP2,NUP160,GTF2A2,ERCC2,SV2B,RANBP2,RNGTT,NCBP1,ELOA,MIR1257,HBEGF,FEN1,NPM1,RPL17,KPNA4,NUP210,CALM2,CDK7,PSMA3,ISG15,UBA52,RPS20,CTNND1,PSMB10,CHMP7,RNMT,RPL13,PSMD7,CALR,TPR,NUP35,RBX1,AP2S1,RPL34,CHMP5,VAMP1,CTNNB1,TAF4B,POLR2J,RPL13A,CHMP2B,KPNA2,PSMD5,RANBP1,RPS6,PSIP1,AP1S3,RPS3A,NELFA,RPL3,PSMC6,XRCC4,PACS1,RPS7,NUP85,RPL7A,NMT2,GRB2,RPL32,EPS15,RPS3,GRSF1,MAP2K4,LIG4,CTDP1,SUPT5H,PSMC3,TAF11,GTF2E2,RANGAP1,UBB,RPL5,TGFB1,NDC1,CBL,LCK,MNAT1,TAF1L,PSMB9,RPS19,XRCC5,SRC,SV2C,RPL39L,TAF3,PSMD14,RPS10,POM121C,NUP205,RPL26L1,RPL35,PSMD8,KPNA3,VTA1,GTF2A1,VAMP2,CD9,RPL27A,ELMO1,GTF2F2,PSMB11,ATP6V1H,RPS29,AP1B1,SH3GL1,PSMB4,TXNRD1,SLC25A4,PSME4,NUP98,KPNA1,CCNT2,SH3GL2,SEM1,LTF,SYT1,ELOA2,CD4,AAAS,POLR2C,RPL21,PSMA8,PSMD4,RPL26,PSMD2,SNAP25,PSMD6,CDH1,NUP50,NUP62,PSMD11,CCNT1,RPL7,RPL9,NUP133,RPS13,PABPN1,GTF2H3,HSP90AA1,RPL6,VPS4A,SUPT16H,RPL37,RPSA,CALM1,B2M,CD247,DOCK2,RPS21,TCEA1,NUP42,PSMA6,STAM2,RPL10L,MAP2K1,SKP1,VPS37B,AP2A1,HMGA1,TAF7,CD28,PSMB8,RPLP1,RAC1,GTF2E1,PDCD6IP,ELL,RPS27,PSMB7,KPNA7,RPL31,RPL19,RPLP0,NUP153,CXCR4,RPS26,STAM,CHMP4B,EEF2,GUCY2C,MIR943,NUP88,RPL11,RPL24,RCC1,PSMC1,TAF9,GTF2H5,RPS15A,CHMP4C,SEH1L,TAF5,CHMP6,SYT2,APOBEC3G,RPL12,MET,NUP43,RPL10A,ARF1,DNAJC3,PSMB6,RPS16,RPS24,RPS14,MAP2K3,CBLL1,POLR2L,MIR1236,PSMD12,RPL18A,POLR2E,MAP2K2,RPS27A,RPL38,NEDD4L,PSMD1,STX1B,NUP37,FYN,PSMB5,RPS15,CLTA,RPS23,VPS37A,RPL22,POLR2D,HGS,RPL37A,RPLP2,HLA-A,NELFCD,RPS28,RPS27L,GTF2H4,NUP93,PSMD13,PAK2,POLR2B,VPS37C,PSME1,RPL30,CD8B,CPSF4,IPO5,RPL23,XPO1,PSMB3,CLTC,AP2A2,NUP54,RPL27,LIG1,SV2A
R-HSA-1660514	Synthesis of PIPs at the Golgi membrane	0.928302498829859	-0.0743976307454888	19	15	0.00166039406685853	9034	10285	55300,93492,5289,5286,55697,5288,200576,5298,22908,5297,9896,30849,375,55361,377	PI4K2B,TPTE2,PIK3C3,PIK3C2A,VAC14,PIK3C2G,PIKFYVE,PI4KB,SACM1L,PI4KA,FIG4,PIK3R4,ARF1,PI4K2A,ARF3
R-HSA-3560801	Defective B3GAT3 causes JDSSDHD	0.928302498829859	-0.0743976307454888	19	15	0.00166039406685853	9034	10285	6383,1464,1463,1634,10082,2262,375790,6382,1462,10675,63827,3339,9672,2817,6385	SDC2,CSPG4,NCAN,DCN,GPC6,GPC5,AGRN,SDC1,VCAN,CSPG5,BCAN,HSPG2,SDC3,GPC1,SDC4
R-HSA-8851708	Signaling by FGFR2 IIIa TM	0.928302498829859	-0.0743976307454888	19	15	0.00166039406685853	9034	10285	2247,4686,5434,5433,5440,2962,2963,5439,5430,5432,2246,22916,2263,5431,5441	FGF2,NCBP1,POLR2E,POLR2D,POLR2K,GTF2F1,GTF2F2,POLR2J,POLR2A,POLR2C,FGF1,NCBP2,FGFR2,POLR2B,POLR2L
R-HSA-4420332	Defective B3GALT6 causes EDSP2 and SEMDJL1	0.928302498829859	-0.0743976307454888	19	15	0.00166039406685853	9034	10285	3339,63827,2817,9672,6385,1464,1463,6383,1634,10082,2262,1462,10675,375790,6382	HSPG2,BCAN,GPC1,SDC3,SDC4,CSPG4,NCAN,SDC2,DCN,GPC6,GPC5,VCAN,CSPG5,AGRN,SDC1
R-HSA-3560783	Defective B4GALT7 causes EDS, progeroid type	0.928302498829859	-0.0743976307454888	19	15	0.00166039406685853	9034	10285	9672,2817,63827,3339,6385,10082,6383,1463,1464,1634,2262,6382,375790,10675,1462	SDC3,GPC1,BCAN,HSPG2,SDC4,GPC6,SDC2,NCAN,CSPG4,DCN,GPC5,SDC1,AGRN,CSPG5,VCAN
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1	0.928302498829859	-0.0743976307454888	19	15	0.00166039406685853	9034	10285	7189,6416,7335,8767,10454,23118,5609,5602,5601,6885,5599,3656,7334,10392,64127	TRAF6,MAP2K4,UBE2V1,RIPK2,TAB1,TAB2,MAP2K7,MAPK10,MAPK9,MAP3K7,MAPK8,IRAK2,UBE2N,NOD1,NOD2
R-HSA-75109	Triglyceride Biosynthesis	0.931983372121412	-0.0704403055271456	82	68	0.00752711976975869	9034	10285	79993,9200,56894,253558,6576,83401,31,79071,392636,84803,11000,2180,79966,122970,344967,6319,80168,3293,116255,401494,10965,117145,79888,2181,64834,81616,201562,60481,11332,2712,284486,23205,57678,23171,54898,51495,6785,51703,100527964,51144,64900,2819,56895,10005,55856,134526,26027,80221,150763,641372,58488,253017,2194,1622,47,5538,84320,55301,9663,9524,23305,55326,346606,197322,137964,84649,55750,23175	ELOVL7,HACD1,AGPAT3,LCLAT1,SLC25A1,ELOVL3,ACACA,ELOVL6,AGMO,GPAT3,SLC27A3,ACSL1,SCD5,ACOT4,LOC344967,SCD,MOGAT2,HSD17B3,MOGAT1,HACD4,ACOT2,THEM4,LPCAT1,ACSL3,ELOVL1,ACSBG2,HACD2,ELOVL5,ACOT7,GK2,THEM5,ACSBG1,GPAM,GPD1L,ELOVL2,HACD3,ELOVL4,ACSL5,LHX4-AS1,HSD17B12,LPIN3,GPD1,AGPAT4,ACOT8,ACOT13,ACOT12,ACOT11,ACSF2,GPAT2,ACOT6,PCTP,TECRL,FASN,DBI,ACLY,PPT1,ACBD6,OLAH,LPIN2,TECR,ACSL6,AGPAT5,MOGAT3,ACSF3,GPAT4,DGAT2,AGK,LPIN1
R-HSA-211000	Gene Silencing by RNA	0.933146518681554	-0.0691930500768269	137	115	0.0127296878459154	9034	10285	3013,4603,54514,55746,8358,653604,8968,57122,136991,8360,10762,23636,8343,8339,23405,9631,8367,126961,3018,8365,5432,8341,8370,8086,4928,8353,5440,192669,8366,121504,8348,8334,55124,8575,8021,9883,26523,9271,23225,9972,29102,23112,8354,8362,5903,128312,84944,23511,8349,27327,23279,5430,11097,8359,5901,9818,56165,11022,57690,113802,8344,54487,54456,3320,3020,8468,79902,5434,8970,8355,5441,8357,348995,8340,7247,8363,7257,81929,94239,5439,8350,8345,7175,8347,129401,8361,192670,4927,57510,8346,3015,8368,3017,53371,3021,55766,27161,91646,3012,23165,100101267,5431,8335,143689,9688,8352,55706,122402,5433,221400,723790,201164,79023,10526,8364	H2AC7,MYBL1,DDX4,NUP133,H3C2,H3C13,H3C7,NUP107,ASZ1,H4C4,NUP50,NUP62,H2BC7,H2BC8,DICER1,NUP155,H4C5,H3C14,H2BC3,H4C8,POLR2C,H2BC15,H4C14,AAAS,NUP98,H3C6,POLR2K,AGO3,H4C2,H4C16,H2BC17,H2AC6,PIWIL2,PRKRA,NUP214,POM121,AGO1,PIWIL1,NUP210,NUP153,DROSHA,TNRC6B,H3C11,H4C12,RANBP2,H2BC26,MAEL,NUP188,H2BC21,TNRC6A,NUP160,POLR2A,NUP42,H4C1,RAN,NUP58,TDRD1,TDRKH,TNRC6C,HENMT1,H2BC6,DGCR8,MOV10L1,HSP90AA1,H3-3A,FKBP6,NUP85,POLR2E,H2BC11,H3C8,POLR2L,H3C10,NUP43,H2BC13,TSN,H4C11,TSNAX,SEH1L,H2AZ2,POLR2J,H3C1,H2BC9,TPR,H2BC4,NUP35,H4C6,AGO4,NUP88,XPO5,H2BC10,H2AZ1,H4C13,H2BC5,NUP54,H3-3B,H2AJ,AGO2,TDRD12,H2AC8,NUP205,POM121C,POLR2B,H2AC4,PIWIL4,NUP93,H3C3,NDC1,TDRD9,POLR2D,TDRD6,H2AC19,PLD6,NUP37,IPO8,H4C3
R-HSA-8854518	AURKA Activation by TPX2	0.933730600194122	-0.0685673189821331	75	62	0.00686296214301528	9034	10285	79959,55755,23332,11064,8655,55835,10540,10733,7532,7840,983,55125,11258,5518,11190,3320,4751,80184,22994,6790,84131,1453,10382,9702,54930,9793,10121,7846,22974,80254,10806,115106,9662,22897,1781,54801,79441,4957,3161,93323,5566,1454,10142,22981,54820,5108,5048,7531,22919,80321,1639,5577,1778,55722,9814,22995,95681,203068,5347,121441,23354,7277	CEP76,CDK5RAP2,CLASP1,CNTRL,DYNLL1,CENPJ,DCTN2,PLK4,YWHAG,ALMS1,CDK1,CEP192,DCTN3,PPP2R1A,CEP250,HSP90AA1,NEK2,CEP290,CEP131,AURKA,CEP78,CSNK1D,TUBB4A,CEP57,HAUS4,CKAP5,ACTR1A,TUBA1A,TPX2,CEP63,SDCCAG8,HAUS1,CEP135,CEP164,DYNC1I2,HAUS6,HAUS3,ODF2,HMMR,HAUS8,PRKACA,CSNK1E,AKAP9,NINL,NDE1,PCM1,PAFAH1B1,YWHAE,MAPRE1,CEP70,DCTN1,PRKAR2B,DYNC1H1,CEP72,SFI1,CEP152,CEP41,TUBB,PLK1,NEDD1,HAUS5,TUBA4A
R-HSA-76046	RNA Polymerase III Transcription Initiation	0.936424492220475	-0.0656863879828793	36	29	0.0032100951959265	9034	10285	51728,2976,55703,9329,6618,5441,55290,6617,5434,27297,112495,55718,2975,7702,10302,2971,10622,9330,9328,6619,10623,11128,84265,171568,5440,5451,51082,661,9533	POLR3K,GTF3C2,POLR3B,GTF3C4,SNAPC2,POLR2L,BRF2,SNAPC1,POLR2E,CRCP,GTF3C6,POLR3E,GTF3C1,ZNF143,SNAPC5,GTF3A,POLR3G,GTF3C3,GTF3C5,SNAPC3,POLR3C,POLR3A,POLR3GL,POLR3H,POLR2K,POU2F1,POLR1D,POLR3D,POLR1C
R-HSA-5668599	RHO GTPases Activate NADPH Oxidases	0.936684249227203	-0.0654090340816932	13	10	0.00110692937790569	9034	10285	1535,5289,30849,4688,653361,5879,50508,4689,124056,5880	CYBA,PIK3C3,PIK3R4,NCF2,NCF1,RAC1,NOX3,NCF4,NOXO1,RAC2
R-HSA-977441	GABA A receptor activation	0.936684249227203	-0.0654090340816932	13	10	0.00110692937790569	9034	10285	2567,2562,2566,2560,2555,2557,2559,2554,2558,2561	GABRG3,GABRB3,GABRG2,GABRB1,GABRA2,GABRA4,GABRA6,GABRA1,GABRA5,GABRB2
R-HSA-350054	Notch-HLH transcription pathway	0.936684249227203	-0.0654090340816932	13	10	0.00110692937790569	9034	10285	84441,8850,4855,9794,55534,3516,22938,1387,4854,4853	MAML2,KAT2B,NOTCH4,MAML1,MAML3,RBPJ,SNW1,CREBBP,NOTCH3,NOTCH2
R-HSA-381033	ATF6 (ATF6-alpha) activates chaperones	0.936684249227203	-0.0654090340816932	13	10	0.00110692937790569	9034	10285	100500842,468,22926,4802,4800,4801,3309,8720,811,7494	MIR3652,ATF4,ATF6,NFYC,NFYA,NFYB,HSPA5,MBTPS1,CALR,XBP1
R-HSA-8850843	Phosphate bond hydrolysis by NTPDase proteins	0.937179333866785	-0.0648806235233493	8	6	0.000664157626743414	9034	10285	956,57089,957,9583,955,953	ENTPD3,ENTPD7,ENTPD5,ENTPD4,ENTPD6,ENTPD1
R-HSA-174430	Telomere C-strand synthesis initiation	0.937179333866785	-0.0648806235233493	8	6	0.000664157626743414	9034	10285	56655,54107,5558,5427,5557,23649	POLE4,POLE3,PRIM2,POLE2,PRIM1,POLA2
R-HSA-5688890	Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	0.937179333866785	-0.0648806235233493	8	6	0.000664157626743414	9034	10285	253970,6439,653509,729238,6441,1439	SFTA3,SFTPB,SFTPA1,SFTPA2,SFTPD,CSF2RB
R-HSA-70921	Histidine catabolism	0.937179333866785	-0.0648806235233493	8	6	0.000664157626743414	9034	10285	3034,138199,144193,3067,3176,131669	HAL,CARNMT1,AMDHD1,HDC,HNMT,UROC1
R-HSA-5688849	Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	0.937179333866785	-0.0648806235233493	8	6	0.000664157626743414	9034	10285	253970,6439,6441,653509,1439,729238	SFTA3,SFTPB,SFTPD,SFTPA1,CSF2RB,SFTPA2
R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	0.937179333866785	-0.0648806235233493	8	6	0.000664157626743414	9034	10285	64841,55577,9945,5238,2673,6675	GNPNAT1,NAGK,GFPT2,PGM3,GFPT1,UAP1
R-HSA-68952	DNA replication initiation	0.937179333866785	-0.0648806235233493	8	6	0.000664157626743414	9034	10285	54107,5558,56655,5427,23649,5557	POLE3,PRIM2,POLE4,POLE2,POLA2,PRIM1
R-HSA-3247509	Chromatin modifying enzymes	0.940722063325087	-0.0611075461227036	279	237	0.0262342262563648	9034	10285	8370,10499,11240,79918,23210,126961,8365,6871,10629,55904,51111,10524,8348,8366,121504,11091,79960,83933,23028,6883,54904,79723,51702,29943,3013,2874,653604,8968,6881,23081,92815,9682,7862,8358,55170,8339,64754,10765,23326,84193,23587,5970,23522,8359,54815,3717,8969,9869,57492,10445,26610,23569,1107,55818,100302237,23030,58508,23135,10933,56979,1387,84787,284058,53615,128312,23774,8362,23186,8349,94239,8350,353238,57325,6595,8361,8347,8520,5978,3276,2033,56950,3015,8850,595,54496,8357,64324,25855,8363,23512,80854,5926,60,8340,10919,63976,79831,8648,27097,2122,1108,8518,4791,723790,8364,7468,10284,55929,79595,8089,80314,3012,3066,26009,112869,221613,84148,23067,51317,387893,3065,9913,9757,8341,6603,79718,8367,3018,10856,1810,55352,51147,79084,8353,22992,10902,6598,51780,8334,8841,51412,7994,117143,8607,6314,56943,55167,1788,8343,6601,5928,8360,64426,55689,79685,440689,57634,55870,84678,9219,8344,9612,8726,10474,84159,5929,54556,6604,54014,55578,4790,8354,6944,10498,6599,57504,83852,8295,1386,10419,51562,84661,80853,6597,121536,64769,9575,10196,8345,54934,339287,6880,51230,84864,9070,11143,56970,8368,3017,8346,55193,54859,9611,8289,55683,5927,8819,8970,8355,8332,2146,5077,6605,55693,8335,55250,29072,84444,8352,10362,5253,55257,51742,6602,4297,196528,57459,55729,23338,55766,8464,693140,55140,1019,86,221656,27154	H4C14,NCOA2,PADI2,SETD6,JMJD6,H3C14,H4C8,TADA2A,TAF6L,KMT2E,KMT5B,KAT5,H2BC17,H4C2,H4C16,WDR5,JADE1,HDAC10,KDM1A,TAF12,NSD3,SUV39H2,PADI3,PADI1,H2AC7,GPS2,H3C13,H3C7,TAF10,KDM4C,H2AC25,KDM4A,BRPF1,H3C2,PRMT6,H2BC8,SMYD3,KDM5B,USP22,SETD3,ELP5,RELA,KAT6B,H4C1,GATAD2A,JAK2,H2AC11,SETDB1,ARID1B,MCRS1,ELP4,PADI4,CHD3,KDM3A,MIR1281,KDM4B,KMT2C,KDM6B,MORF4L1,PRDM9,CREBBP,KMT5C,KANSL1,MBD3,H2BC26,BRD1,H4C12,RCOR1,H2BC21,H2AZ2,H3C1,PADI6,KAT14,SMARCA2,H4C6,H2BC4,HAT1,REST,PRMT1,EP300,SMYD2,H2AZ1,KAT2B,CCND1,PRMT7,H3C10,NSD1,BRMS1,H4C11,SUZ12,SETD7,ARID4A,ACTB,H2BC13,EHMT2,PRDM16,KDM8,NCOA1,TAF5L,MECOM,CHD4,ELP1,NFKB2,H2AC19,H4C3,NSD2,SAP18,DMAP1,SAP130,YEATS4,EPC1,H2AC8,HDAC2,ZZZ3,SGF29,H2AC1,KAT8,SETD1B,PHF21A,KMT5A,HDAC1,SUPT7L,KMT2B,H2BC15,SMARCD2,TBL1XR1,H4C5,H2BC3,RUVBL2,DR1,COPRS,ING4,WDR77,H3C6,KDM2A,BRD8,SMARCB1,KDM3B,H2AC6,HDAC3,ACTL6B,KAT6A,TADA1,RUVBL1,ATXN7,ENY2,MSL2,DNMT3A,H2BC7,SMARCC2,RBBP4,H4C4,SUDS3,YEATS2,SAP30L,H2BC18,EP400,ASH1L,KDM2B,MTA2,H2BC6,NCOR2,EED,TADA3,ARID5B,RBBP5,ING3,SMARCD3,BRWD1,SUPT20H,NFKB1,H3C11,VPS72,CARM1,SMARCC1,MTA3,SETDB2,TRRAP,ATF2,PRMT5,MBIP,DPY30,KDM7A,SMARCA4,AEBP2,MEAF6,CLOCK,PRMT3,H2BC9,KANSL2,MSL1,TAF9,PHF20,RIOX2,ASH2L,KAT7,ATXN7L3,H4C13,H2BC5,H2BC10,PBRM1,ELP6,NCOR1,ARID1A,KANSL3,KDM5A,SAP30,H2BC11,H3C8,H2AC16,EZH2,PAX3,SMARCE1,KDM4D,H2AC4,ELP2,SETD2,DOT1L,H3C3,HMG20B,PHF2,MRGBP,ARID4B,SMARCD1,KMT2A,ARID2,GATAD2B,ATF7IP,JADE2,H2AJ,SUPT3H,MIR555,ELP3,CDK4,ACTL6A,KDM1B,BRPF3
R-HSA-4839726	Chromatin organization	0.940722063325087	-0.0611075461227036	279	237	0.0262342262563648	9034	10285	22992,8353,55352,79084,51147,1810,10856,3018,8367,6603,79718,8341,8334,51780,6598,10902,1788,55167,56943,8607,6314,117143,7994,51412,8841,440689,79685,55689,64426,8360,5928,6601,8343,9219,84678,55870,57634,5929,84159,10474,8726,9612,8344,8354,4790,55578,6604,54014,54556,10419,1386,8295,83852,57504,6599,10498,6944,9575,10196,8345,64769,121536,6597,80853,84661,51562,8346,3017,8368,11143,56970,9070,84864,51230,6880,54934,339287,5927,55683,8289,54859,9611,55193,6605,5077,2146,8332,8355,8819,8970,4297,6602,51742,55257,5253,10362,8352,84444,29072,55250,55693,8335,57459,196528,55140,1019,693140,8464,55766,23338,55729,27154,221656,86,55904,51111,10629,6871,8365,126961,23210,11240,79918,10499,8370,79723,54904,6883,23028,79960,83933,11091,121504,8366,8348,10524,7862,8358,92815,23081,9682,6881,8968,653604,2874,3013,29943,51702,5970,84193,23587,23326,10765,64754,8339,55170,55818,1107,23569,26610,10445,57492,9869,8969,3717,54815,8359,23522,23135,58508,23030,100302237,53615,284058,84787,1387,56979,10933,8349,23186,8362,23774,128312,8520,8347,8361,6595,57325,353238,8350,94239,3015,56950,2033,3276,5978,54496,595,8850,60,8340,5926,80854,23512,8363,25855,64324,8357,2122,27097,8648,79831,63976,10919,10284,7468,8364,723790,4791,8518,1108,3066,3012,80314,79595,8089,55929,9757,3065,9913,387893,51317,23067,221613,84148,26009,112869	KDM2A,H3C6,COPRS,WDR77,ING4,DR1,RUVBL2,H2BC3,H4C5,SMARCD2,TBL1XR1,H2BC15,H2AC6,KDM3B,SMARCB1,BRD8,DNMT3A,MSL2,ENY2,RUVBL1,ATXN7,TADA1,KAT6A,ACTL6B,HDAC3,H2BC18,SAP30L,YEATS2,SUDS3,H4C4,RBBP4,SMARCC2,H2BC7,MTA2,KDM2B,ASH1L,EP400,RBBP5,ARID5B,TADA3,EED,NCOR2,H2BC6,H3C11,NFKB1,SUPT20H,SMARCD3,BRWD1,ING3,PRMT5,ATF2,TRRAP,SETDB2,MTA3,SMARCC1,CARM1,VPS72,CLOCK,PRMT3,H2BC9,MEAF6,AEBP2,SMARCA4,KDM7A,DPY30,MBIP,H2BC10,H2BC5,H4C13,KAT7,ATXN7L3,ASH2L,RIOX2,PHF20,TAF9,KANSL2,MSL1,KDM5A,KANSL3,ARID1A,ELP6,NCOR1,PBRM1,SMARCE1,PAX3,EZH2,H2AC16,H3C8,SAP30,H2BC11,KMT2A,SMARCD1,ARID4B,MRGBP,PHF2,HMG20B,H3C3,DOT1L,SETD2,ELP2,KDM4D,H2AC4,GATAD2B,ARID2,ELP3,CDK4,MIR555,SUPT3H,H2AJ,JADE2,ATF7IP,BRPF3,KDM1B,ACTL6A,KMT2E,KMT5B,TAF6L,TADA2A,H4C8,H3C14,JMJD6,PADI2,SETD6,NCOA2,H4C14,SUV39H2,NSD3,TAF12,KDM1A,JADE1,HDAC10,WDR5,H4C16,H4C2,H2BC17,KAT5,BRPF1,H3C2,H2AC25,KDM4C,KDM4A,TAF10,H3C7,H3C13,GPS2,H2AC7,PADI1,PADI3,RELA,SETD3,ELP5,USP22,KDM5B,SMYD3,H2BC8,PRMT6,KDM3A,CHD3,PADI4,ELP4,MCRS1,ARID1B,SETDB1,H2AC11,JAK2,GATAD2A,H4C1,KAT6B,KDM6B,KMT2C,KDM4B,MIR1281,MBD3,KANSL1,KMT5C,CREBBP,PRDM9,MORF4L1,H2BC21,RCOR1,H4C12,BRD1,H2BC26,HAT1,H2BC4,H4C6,SMARCA2,KAT14,PADI6,H3C1,H2AZ2,H2AZ1,SMYD2,EP300,PRMT1,REST,PRMT7,CCND1,KAT2B,ACTB,H2BC13,ARID4A,SETD7,SUZ12,H4C11,BRMS1,NSD1,H3C10,MECOM,TAF5L,NCOA1,KDM8,PRDM16,EHMT2,SAP18,NSD2,H4C3,H2AC19,NFKB2,ELP1,CHD4,HDAC2,H2AC8,EPC1,SAP130,YEATS4,DMAP1,KMT2B,HDAC1,SUPT7L,KMT5A,PHF21A,SETD1B,H2AC1,KAT8,ZZZ3,SGF29
R-HSA-5676594	TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	0.941540424435796	-0.0602379956029492	18	14	0.00154970112906797	9034	10285	330,4055,8740,958,8742,10673,4049,329,7187,9020,4050,115650,8792,8600	BIRC3,LTBR,TNFSF14,CD40,TNFSF12,TNFSF13B,LTA,BIRC2,TRAF3,MAP3K14,LTB,TNFRSF13C,TNFRSF11A,TNFSF11
R-HSA-196757	Metabolism of folate and pterines	0.941540424435796	-0.0602379956029492	18	14	0.00154970112906797	9034	10285	160428,1719,4524,4522,200895,81034,10840,441024,10588,10797,25902,6470,6472,2350	ALDH1L2,DHFR,MTHFR,MTHFD1,DHFR2,SLC25A32,ALDH1L1,MTHFD2L,MTHFS,MTHFD2,MTHFD1L,SHMT1,SHMT2,FOLR2
R-HSA-68886	M Phase	0.941888477745709	-0.0598684002192611	308	262	0.0290015497011291	9034	10285	51529,8345,9700,9735,81929,57405,3017,5048,8368,8346,9184,23063,23122,5700,4927,79980,5528,5718,7112,5707,25906,6233,5694,348995,8355,81876,8970,2801,3619,6396,79019,4001,8352,5529,5719,9688,100616122,23592,8335,25909,5693,5862,29945,79023,9918,11004,8697,7514,5691,51433,55766,23175,53371,9183,9663,5720,1457,7979,55839,25836,81565,996,23198,8353,4928,5347,143471,5520,3796,5710,8086,8341,3018,8367,1459,122706,8334,55920,5692,9133,55746,23383,5861,55055,9861,5708,8548,699,5527,5717,64689,5519,23636,8343,701,8360,10762,1060,57551,11097,5687,332,113130,64682,983,3020,10726,5518,8344,6418,57082,23310,6232,991,8354,9232,9972,5695,11243,84643,5696,8361,129401,8347,5713,2029,7175,8350,94239,3015,5684,83540,64105,5595,11130,5699,7311,5925,151246,79902,4085,6249,8363,81930,5885,8615,8340,5711,23421,8357,5706,91754,9212,5905,119504,9793,55706,5515,79172,8379,54908,7314,1063,8364,10393,401541,5501,5702,5516,723790,9126,51434,3012,5714,147841,3021,10112,5698,387893,891,151648,23332,220134,100101267,23165,10213,1062,26271,7316,23244,80152,255919,5578,8370,8365,126961,9631,22919,9883,8021,9491,8348,10197,7444,121504,8366,8968,57122,653604,25936,8358,10776,5701,9493,5526,10051,64946,23397,3013,54820,23047,79682,54892,8339,5715,5525,5682,7324,11065,9818,5594,8290,8815,5685,8359,10274,84930,10783,64900,1058,5686,221496,10592,5690,80776,10403,64151,23225,5579,26003,7321,79648,23279,8349,23511,5704,128312,5903,8362,7443,140609,4000	ANAPC11,H2BC9,ESPL1,KNTC1,SEH1L,SPC25,H2BC5,PAFAH1B1,H4C13,H2BC10,BUB3,WAPL,CLASP2,PSMC1,NUP88,DSN1,PPP2R5D,PSMD12,TMPO,PSMD1,ANAPC15,RPS27A,PSMB6,NUP43,H3C8,RAB1B,H2BC11,GOLGA2,INCENP,SEC13,CENPM,LMNB1,H3C3,PPP2R5E,PSMD13,NUP93,MIR4523,LEMD3,H2AC4,AHCTF1,PSMB5,RAB2A,ANAPC4,NUP37,NCAPD2,KIF2C,CDC23,XPO1,PSMB3,ANAPC5,H2AJ,LPIN1,NUP54,ZW10,LPIN2,PSME1,CSNK2A1,SEM1,CENPN,NIPBL,NDEL1,CDC27,PSME4,H3C6,NUP98,PLK1,PSMA8,PPP2R2A,KIF2A,PSMD4,AAAS,H2BC15,H2BC3,H4C5,CSNK2A2,PSMB11,H2AC6,RCC2,PSMB4,CCNB2,NUP133,MAU2,RAB1A,ZWILCH,PSMD6,PSMD2,BLZF1,BUB1,PPP2R5C,PSMD11,GORASP1,PPP2R1B,NUP62,H2BC7,BUB1B,H4C4,NUP50,CENPC,TAOK1,NUP42,PSMA6,BIRC5,CDCA5,ANAPC1,CDK1,H3-3A,NUDC,PPP2R1A,H2BC6,SET,KNL1,NCAPD3,RPS27,CDC20,H3C11,PTTG1,NUP153,PSMB7,PMF1,KIF2B,PSMB8,H4C6,NUP35,H2BC4,PSMD7,ENSA,TPR,H3C1,H2AZ2,H2AZ1,PSMA3,NUF2,CENPK,MAPK3,ZWINT,PSMB10,UBA52,RB1,SGO2,NUP85,MAD2L1,CLIP1,H4C11,KIF18A,RAD21,USO1,H2BC13,PSMD5,ITGB3BP,H3C10,PSMC6,NEK9,AURKB,RANGAP1,ANAPC16,CKAP5,NDC1,PPP2CA,CENPO,MAD1L1,SPDL1,UBB,CENPF,H4C3,ANAPC10,CENPP,PPP1CC,PSMC3,PPP2CB,H2AC19,SMC3,ANAPC7,H2AC8,PSMD8,SPC24,H3-3B,KIF20A,PSMB9,KMT5A,CCNB1,SGO1,CLASP1,SKA1,POM121C,NUP205,PSMD14,CENPE,FBXO5,UBC,PDS5A,CENPT,CNEP1R1,PRKCA,H4C14,H4C8,H3C14,NUP155,MAPRE1,POM121,NUP214,PSMF1,H2BC17,PSME3,VRK2,H4C16,H4C2,H3C7,NUP107,H3C13,NSL1,H3C2,ARPP19,PSMC2,KIF23,PPP2R5B,SMC4,CENPH,NCAPH,H2AC7,NDE1,PDS5B,CENPU,NCAPG2,H2BC8,PSMD9,PPP2R5A,PSMA1,UBE2E1,UBE2C,NUP58,MAPK1,H3-4,BANF1,PSMA4,H4C1,STAG1,MASTL,NEK6,LPIN3,CENPA,PSMA5,LEMD2,SMC2,PSMB2,B9D2,NDC80,NCAPG,NUP210,PRKCB,GORASP2,UBE2D1,MCPH1,NUP160,H2BC21,NUP188,PSMC4,H2BC26,RANBP2,H4C12,VRK1,NEK7,LMNA
R-HSA-5358346	Hedgehog ligand biogenesis	0.942058273152369	-0.0596881452231597	67	55	0.00608811157848129	9034	10285	5698,5704,5720,5696,147111,10213,5691,6400,5714,5695,5693,6469,2262,5686,5702,5690,5687,5685,5719,7314,9861,5694,55733,5711,5708,5682,5715,5706,5717,6868,5701,3549,10956,5718,50846,5707,6233,7415,122706,5684,10197,5700,9491,84447,57758,7311,5699,5692,5034,7316,7979,5713,23198,5710,143471	PSMB9,PSMC4,PSME1,PSMB8,NOTUM,PSMD14,PSMB3,SEL1L,PSMD8,PSMB7,PSMB5,SHH,GPC5,PSMA5,PSMC3,PSMB2,PSMA6,PSMA4,PSMD13,UBB,PSMD6,PSMB6,HHAT,PSMD5,PSMD2,PSMA1,PSMD9,PSMC6,PSMD11,ADAM17,PSMC2,IHH,OS9,PSMD12,DHH,PSMD1,RPS27A,VCP,PSMB11,PSMA3,PSME3,PSMC1,PSMF1,SYVN1,SCUBE2,UBA52,PSMB10,PSMB4,P4HB,UBC,SEM1,PSMD7,PSME4,PSMD4,PSMA8
R-HSA-5387390	Hh mutants abrogate ligand secretion	0.945066925067427	-0.0564995338188535	60	49	0.00542395395173788	9034	10285	5696,10213,5720,5704,5698,5695,5714,6400,5691,5690,5702,5686,6469,5693,7314,5685,5719,5687,5706,5717,5682,5715,5708,5711,9861,5694,7415,6233,5707,50846,3549,10956,5718,5701,5699,5692,7311,10197,5700,9491,84447,5684,122706,5710,143471,23198,5713,7979,7316	PSMB8,PSMD14,PSME1,PSMC4,PSMB9,PSMB7,PSMD8,SEL1L,PSMB3,PSMB2,PSMC3,PSMA5,SHH,PSMB5,UBB,PSMA4,PSMD13,PSMA6,PSMC6,PSMD11,PSMA1,PSMD9,PSMD2,PSMD5,PSMD6,PSMB6,VCP,RPS27A,PSMD1,DHH,IHH,OS9,PSMD12,PSMC2,PSMB10,PSMB4,UBA52,PSME3,PSMC1,PSMF1,SYVN1,PSMA3,PSMB11,PSMD4,PSMA8,PSME4,PSMD7,SEM1,UBC
R-HSA-72165	mRNA Splicing - Minor Pathway	0.948799741294374	-0.0525575234048452	53	43	0.00475979632499447	9034	10285	5440,6637,6635,5439,5432,10907,24148,6636,6432,23020,10262,10594,4809,4904,2962,5434,6426,9343,11066,55954,10081,5441,6633,23451,5433,57819,83443,5430,6628,154007,9416,79622,10992,4686,6431,11325,85437,2963,55599,9410,5431,22916,51639	POLR2K,SNRPG,SNRPE,POLR2J,POLR2C,TXNL4A,PRPF6,SNRPF,SRSF7,SNRNP200,SF3B4,PRPF8,SNU13,YBX1,GTF2F1,POLR2E,SRSF1,EFTUD2,SNRNP35,ZMAT5,PDCD7,POLR2L,SNRPD2,SF3B1,POLR2D,LSM2,SF3B5,POLR2A,SNRPB,SNRNP48,DDX23,SNRNP25,SF3B2,NCBP1,SRSF6,DDX42,ZCRB1,GTF2F2,RNPC3,SNRNP40,POLR2B,NCBP2,SF3B6
R-HSA-6794362	Protein-protein interactions at synapses	0.950395881316705	-0.0508766640145594	72	59	0.00653088332964357	9034	10285	9455,78999,22871,1740,2903,1739,5792,28988,9456,22839,57555,127833,6857,9066,26037,9378,9229,2036,2915,2906,2911,5789,8825,2035,2037,5802,2905,143425,10313,6812,9546,10611,91683,1742,341359,23136,9379,9228,57497,2890,50944,10211,57669,2893,347730,347731,9454,58512,2319,321,2904,26045,80059,57596,55327,320,9369,79414,22941	HOMER2,LRFN4,NLGN1,DLG2,GRIN2A,DLG1,PTPRF,DBNL,HOMER1,DLGAP4,NLGN2,SYT2,SYT1,SYT7,SIPA1L1,NRXN1,DLGAP1,EPB41L1,GRM5,GRIN2D,GRM1,PTPRD,LIN7A,EPB41,EPB41L2,PTPRS,GRIN2C,SYT9,RTN3,STXBP1,APBA3,PDLIM5,SYT12,DLG4,SYT10,EPB41L3,NRXN2,DLGAP2,LRFN2,GRIA1,SHANK1,FLOT1,EPB41L5,GRIA4,LRRTM1,LRRTM3,HOMER3,DLGAP3,FLOT2,APBA2,GRIN2B,LRRTM2,LRRTM4,BEGAIN,LIN7C,APBA1,NRXN3,LRFN3,SHANK2
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	0.950395881316705	-0.0508766640145594	72	59	0.00653088332964357	9034	10285	121441,5347,7277,23354,55722,1778,203068,22995,95681,9814,5577,1639,22919,7531,5048,80321,22981,5108,54820,10142,1454,4957,79441,5566,93323,115106,10806,80254,54801,1781,22897,9662,9793,10121,7846,1453,84131,10382,22994,54930,9702,4751,80184,55125,983,11258,3320,11190,5518,10540,55835,7840,7532,10733,8655,11064,55755,79959,23332	NEDD1,PLK1,TUBA4A,HAUS5,CEP72,DYNC1H1,TUBB,CEP152,CEP41,SFI1,PRKAR2B,DCTN1,MAPRE1,YWHAE,PAFAH1B1,CEP70,NINL,PCM1,NDE1,AKAP9,CSNK1E,ODF2,HAUS3,PRKACA,HAUS8,HAUS1,SDCCAG8,CEP63,HAUS6,DYNC1I2,CEP164,CEP135,CKAP5,ACTR1A,TUBA1A,CSNK1D,CEP78,TUBB4A,CEP131,HAUS4,CEP57,NEK2,CEP290,CEP192,CDK1,DCTN3,HSP90AA1,CEP250,PPP2R1A,DCTN2,CENPJ,ALMS1,YWHAG,PLK4,DYNLL1,CNTRL,CDK5RAP2,CEP76,CLASP1
R-HSA-380259	Loss of Nlp from mitotic centrosomes	0.950395881316705	-0.0508766640145594	72	59	0.00653088332964357	9034	10285	8655,55835,10540,10733,7532,7840,79959,55755,23332,11064,22994,84131,1453,10382,9702,54930,9793,10121,7846,983,11258,55125,5518,11190,3320,4751,80184,1454,10142,22981,54820,5108,80254,10806,115106,9662,22897,54801,1781,79441,4957,93323,5566,1778,55722,22995,95681,9814,203068,121441,5347,23354,7277,5048,7531,22919,80321,1639,5577	DYNLL1,CENPJ,DCTN2,PLK4,YWHAG,ALMS1,CEP76,CDK5RAP2,CLASP1,CNTRL,CEP131,CEP78,CSNK1D,TUBB4A,CEP57,HAUS4,CKAP5,ACTR1A,TUBA1A,CDK1,DCTN3,CEP192,PPP2R1A,CEP250,HSP90AA1,NEK2,CEP290,CSNK1E,AKAP9,NINL,NDE1,PCM1,CEP63,SDCCAG8,HAUS1,CEP135,CEP164,HAUS6,DYNC1I2,HAUS3,ODF2,HAUS8,PRKACA,DYNC1H1,CEP72,CEP152,CEP41,SFI1,TUBB,NEDD1,PLK1,HAUS5,TUBA4A,PAFAH1B1,YWHAE,MAPRE1,CEP70,DCTN1,PRKAR2B
R-HSA-391251	Protein folding	0.951651357830041	-0.0495565320327369	105	87	0.0096302855877795	9034	10285	84261,55135,22803,8877,7280,2780,51807,2783,10693,7278,1459,7277,7157,1155,63971,402,5203,898,406974,84790,2791,2771,6904,10381,2770,2790,112714,2786,26234,6468,2788,22948,5201,26330,60,81027,2793,2773,10575,6902,6774,10694,10238,8841,2787,3801,2781,10576,6905,26270,2782,2629,26190,6000,10376,8786,83752,51764,7846,9628,10681,59345,84617,10528,8787,10382,9134,26272,1457,26985,2779,2792,10564,26224,2784,11328,54331,79861,55970,10574,346562,5082,347733,55294,5204,94235,6903	FBXW9,WRAP53,XRN2,SPHK1,TUBB2A,GNAT2,TUBA8,GNB2,CCT6B,TUBA3C,CSNK2A2,TUBA4A,TP53,TBCB,KIF13A,ARL2,PFDN4,CCNE1,MIR197,TUBA1C,GNG11,GNAI2,TBCD,TUBB3,GNAI1,GNG10,TUBA3E,GNG4,FBXL5,FBXW4,GNG7,CCT5,PFDN1,GAPDHS,ACTB,TUBB1,GNGT2,GNAI3,CCT4,TBCA,STAT3,CCT8,DCAF7,HDAC3,GNG5,KIFC3,GNAZ,CCT2,TBCE,FBXO6,GNB1,GBA1,FBXW2,RGS7,TUBA1B,RGS11,LONP2,GNG13,TUBA1A,RGS6,GNB5,GNB4,TUBB6,NOP56,RGS9,TUBB4A,CCNE2,FBXO4,CSNK2A1,AP3M1,GNAT1,GNGT1,ARFGEF2,FBXL3,GNB3,FKBP9,GNG2,TUBAL3,GNG12,CCT7,GNAT3,PDCL,TUBB2B,FBXW7,PFDN5,GNG8,TBCC
R-HSA-3656253	Defective EXT1 causes exostoses 1, TRPS2 and CHDS	0.951653350810488	-0.0495544378011224	12	9	0.000996236440115121	9034	10285	6383,3339,10082,9672,2817,6385,2262,6382,375790	SDC2,HSPG2,GPC6,SDC3,GPC1,SDC4,GPC5,SDC1,AGRN
R-HSA-3656237	Defective EXT2 causes exostoses 2	0.951653350810488	-0.0495544378011224	12	9	0.000996236440115121	9034	10285	6383,3339,2817,10082,9672,2262,6385,375790,6382	SDC2,HSPG2,GPC1,GPC6,SDC3,GPC5,SDC4,AGRN,SDC1
R-HSA-597592	Post-translational protein modification	0.951678262813804	-0.0495282605410601	1034	892	0.0987381005091875	9034	10285	5868,201475,5371,22820,146183,92949,23145,997,3190,4045,808,7417,2589,92815,10956,5701,9491,10652,57599,6045,50863,5045,148789,9631,10113,54344,10678,9958,3972,10868,10175,128312,10825,23511,29926,90268,442117,55757,7048,339122,64750,51611,7323,9099,54623,5686,26286,10454,27095,55907,5869,122553,3091,123904,6489,9609,11173,8581,79875,5706,4086,9570,401258,9215,8615,5885,79672,2147,11227,6885,8934,7518,10402,51146,11316,54926,123228,10026,2683,197370,7322,360226,79577,55611,5067,9577,9334,1604,140687,140453,27430,374907,54891,93183,10942,286,5329,5714,248,723790,84749,8790,11096,3742,401409,387,84101,79155,9212,23137,993,64426,126119,29089,9545,5717,26984,23243,8343,440689,377,330,9986,26503,10972,10071,29880,10054,57134,2822,5692,9960,285381,8875,8334,10299,6710,23256,51762,5710,170692,4218,143471,146760,5878,4928,23198,7844,10617,4245,55014,79642,7334,5695,51035,3703,221143,6400,8655,55291,10890,54732,5281,64127,332,10254,84364,6670,1075,8970,2650,51255,56886,23586,27076,9945,79053,120071,10331,65264,1938,85365,8724,51552,7158,197258,9804,80055,3017,51014,6184,57171,7903,220441,1780,10196,8345,7345,149111,86,4092,89978,8704,9276,54965,90865,4286,83452,1368,79931,84142,287,79023,1294,5693,29954,54617,2590,727897,118430,10559,56052,5071,11065,54764,1781,23556,7508,6502,9488,10392,84733,5873,1650,9868,57111,10905,8348,10197,256435,51301,8312,137797,23682,9883,80740,29929,83548,6478,51046,7155,64284,55568,580,26958,5903,54437,8349,171019,10427,7070,5704,2591,57403,84752,966,5537,79091,4609,8693,7058,55738,55252,7528,11258,51564,10318,10445,55031,11196,10959,1453,63967,22818,7153,54187,7128,60,7109,2673,219333,5711,83639,84620,140735,91949,6711,8850,100500853,146712,11015,329,81794,5699,84002,4122,2033,407043,3183,1639,7022,5684,51715,124872,7879,375056,80896,4249,205564,100500827,10213,8658,23165,4905,5698,4193,23172,10540,9810,23463,5872,4248,57646,4287,63917,114803,9817,8313,9331,57188,1802,79947,27090,114805,80328,152330,53917,5905,140838,57695,84196,8128,1725,7416,4061,23011,11226,79090,11041,1911,55343,2813,51602,324,23275,378,7329,284098,6483,8086,22901,7353,57731,7328,8295,116150,9695,55624,10869,80267,153642,2350,79796,29086,9037,9245,6612,7841,6811,433,57332,7706,5687,9929,11097,338328,6790,59343,84892,9509,11070,157869,2517,4087,5707,338596,168391,10960,5865,7187,83696,51164,64377,5700,79694,6613,100287144,6048,84720,100313843,251,144245,408,288,154,11236,192134,4253,6015,672,5720,128869,11320,349633,55432,10945,120526,55741,53371,57559,641,63908,125476,55577,54780,7264,114548,1540,3607,8869,9508,8915,5862,349667,57511,10484,6482,257194,10802,8339,5682,84628,9526,10966,4124,79823,8434,632,4792,6881,9101,4588,64409,170689,93010,51560,80070,22845,5373,5279,9871,10418,432,3093,23279,4589,7321,170690,23225,23627,84516,51809,91445,1048,78990,1087,394263,254013,339366,1080,5589,8969,5874,5685,4758,7486,8554,84342,8314,116372,8729,6487,5111,9097,50614,5886,5867,648,57799,55350,5238,27005,140766,493861,4194,56957,10195,22931,84920,129401,4351,811,6480,9382,79609,128637,8813,9632,51720,7326,51651,3998,55236,3312,9656,390243,27314,58485,3630,7419,9126,5702,51604,64122,9761,7314,7040,55706,25834,54872,5372,51226,9117,10762,79677,130576,7150,9861,10585,5893,80731,117248,2153,9063,55746,51299,8607,267,6975,51588,1029,122706,10282,3018,29843,10610,2677,8876,8341,10477,7157,7979,55901,151194,53942,5864,5696,7991,29925,56913,326624,7341,10981,340075,6484,419,81792,80351,991,91833,5283,55650,91869,51332,683,1122,11031,161357,1522,2801,3619,377630,283899,57452,3416,51272,81876,348995,375,2625,4597,5718,5870,9486,11021,8027,381,51322,4927,374378,9736,8346,2155,81929,10466,7369,7007,8073,200958,221656,4241,147719,2348,22944,83475,10055,79913,9510,5691,11095,9554,254263,29761,7020,84932,63891,8000,5719,9688,249,8766,64841,9146,2530,7324,93973,8774,5715,90411,165918,10232,123169,23326,1801,79594,3013,2099,23770,11093,57122,80012,5591,22854,8021,1315,79369,22796,266727,821,6996,55284,1984,1783,6672,8858,81849,30815,92912,7316,8678,4247,8900,6675,51143,7021,11047,2159,11014,56254,4121,890,5690,2525,100302237,1605,84282,6712,2762,10274,9818,7039,57506,143662,56667,8340,79644,9487,10600,79902,4978,409,8078,56999,7311,54734,25837,5423,805,372,10417,23423,8975,8347,7175,646627,5876,5713,10670,221613,7347,55768,100101267,64772,142,56648,221981,285362,8535,196483,23193,1603,23168,3012,56160,9646,89866,8767,55288,22872,11282,2215,5265,5627,7057,2890,4583,54742,64689,161725,23636,6117,4088,411,5708,29906,154064,5861,7415,420,6708,284348,9527,51128,9091,79623,6314,51693,79139,23252,286053,64135,8737,5624,25950,10020,145173,1778,10342,171169,115273,51377,11174,9972,55777,25839,51227,79695,199857,4089,58530,8344,79748,8702,10474,5728,23358,79087,7189,94025,6185,1043,9507,801,6709,7375,7874,6396,8332,10206,5887,5694,6233,10164,135228,26290,115827,1915,25862,9100,2720,1643,84447,8703,55647,353091,374,83746,4585,84132,55808,81847,22955,8924,221937,1081,2804,170691,7046,7703,7327,9781,10671,9719,8818,1912,7320,8335,4798,4062,54507,23032,7332	RAB5A,RAB12,PML,COPG1,OTOA,ADAMTSL1,SSPOP,CDC34,HNRNPK,LSAMP,CALM3,VDAC2,GALNT1,H2AC25,OS9,PSMC2,PSMF1,YKT6,WDR48,RNF2,NTM,FURIN,B3GALNT2,NUP155,PREB,DPM3,B3GNT2,USP15,LHB,USP20,CNIH1,H2BC26,NEU3,NUP188,GMPPA,OTULIN,GALNTL6,UGGT2,TGFBR2,RAB43,SMURF2,DPH5,UBE2D3,USP2,PAF1,PSMA5,ARFGAP3,TAB1,TRAPPC3,CMAS,RAB5B,TRAPPC6B,HIF1A,NRN1L,ST8SIA1,RAB36,ADAMTS7,LY6D,THSD4,PSMC6,SMAD1,GOSR2,RAB44,LARGE1,USO1,RAD21,FN3KRP,F2,GALNT5,MAP3K7,RAB29,XRCC4,ST3GAL6,A4GNT,COPE,UBE2R2,SENP8,PIGK,B4GALT1,NSMCE1,UBE2D2,PRSS41,CDC73,OTUB1,CNTN3,BABAM2,B4GALT5,CD55,GCNT7,MUC17,MAT2B,B3GNT8,INO80D,PIGM,PRSS21,ANK1,PLAUR,PSMD8,ALPI,H2AC19,USP30,FPGT,ADAMTS5,KCNA6,RAB19,RHOA,USP44,TNIP2,AURKB,SMC5,CDC25A,SUDS3,JOSD2,UBE2T,RAB3D,PSMD11,SEC22A,ANKRD28,H2BC7,H2BC18,ARF3,BIRC3,RCE1,SLC17A5,TMED10,MUC12,ALG5,UBA2,MAN1C1,GPLD1,PSMB4,USP3,DPH3,VNN2,H2AC6,MARCHF6,SPTB,SCFD1,RAB8B,PSMD4,ADAMTS18,RAB8A,PSMA8,RTN4RL1,RAB5C,NUP98,PSME4,RNF103,STAMBP,MGAT1,STX17,ARSJ,UBE2N,PSMB7,UBXN1,STT3A,EEF1AKMT1,SEL1L,DYNLL1,PPP6R3,RAB10,TMED9,PIGF,NOD2,BIRC5,STAM2,ARFGAP2,SP3,CTSC,H2BC11,GCNT1,RNF181,UGGT1,RIGI,LYPD3,GFPT2,ALG8,LARGE2,B3GNT3,UBE2Z,EEF2,ALG2,SNX3,RAB14,TP53BP1,FCSK,TOMM20,PGAP1,H2BC5,TMED7,RPN1,DOLPP1,ST8SIA4,RNF152,DYNC1I1,PRMT3,H2BC9,UCHL1,CNIH3,ACTL6A,SMAD7,DPH6,B4GALT2,COPB2,PIGX,IL33,MITF,RAB33B,CPM,TNIP3,ABRAXAS1,ANK2,NUP37,COL7A1,PSMB5,POMT2,INO80,GALNT2,MUC5B,MUCL1,SLC35A1,ALG1,PRKN,UBE2C,ZRANB1,DYNC1I2,PIGN,XPC,SKP2,PIGB,NOD1,CBX2,RAB27A,DDOST,TOMM70,RAB25,MAN1A2,H2BC17,PSME3,ST6GALNAC3,GCNT4,AXIN1,LYPD2,RAB38,POM121,LY6G6C,ALG6,COG3,SIAH2,ST8SIA3,TOP2B,RAB17,GALNT10,BARD1,COPG2,RANBP2,SEMA5B,H2BC21,ADAMTS19,SEC24B,THY1,PSMC4,GALNT3,RAB22A,B3GNT9,CD59,PPP6C,METTL22,MYC,GALNT4,THBS2,ARFGAP1,ASXL2,YY1,DCTN3,HDAC7,TNIP1,MCRS1,USP47,SEC23IP,TMED2,CSNK1D,CLSPN,COPZ1,TOP2A,NANS,TNFAIP3,ACTB,TRAPPC10,GFPT1,USP12,PSMD5,TEX101,ST6GAL2,DYNLL2,COG7,SPTBN1,KAT2B,MIR3605,B3GNTL1,KDELR3,BIRC2,ADAMTS10,PSMB10,B3GNT5,MAN2A2,EP300,MIR7-1,HNRNPC,DCTN1,TFAP2C,PSMA3,RAB23,B4GALNT2,RAB7A,MIA3,NPL,MGAT5,SENP5,MIR3614,PSMD14,TNKS,NUP205,NSF,PSMB9,MDM2,ABRAXAS2,DCTN2,RNF40,ICMT,RAB13,MGAT3,USP28,ATXN3,GALNT11,MYSM1,KEAP1,AXIN2,B4GALT6,ADAMTSL3,DPH2,DHDDS,ST6GALNAC4,GALNT13,ULBP2,CNTN4,RAB24,RANGAP1,NANP,USP37,USP48,ST8SIA2,DHPS,VDAC1,LY6E,RAB21,GALNT6,TRAPPC6A,B4GAT1,PHC1,SLC35C1,GP2,NOP58,APC,POFUT2,ARF4,UBE2I,PIGW,ST3GAL2,AAAS,ARSG,UFD1,SPTBN4,UBE2H,TRRAP,NUS1,EDEM1,POMGNT1,USP19,EDEM3,ARSK,FOLR2,ALG9,BABAM1,SEMA5A,GCNT3,SUMO3,MOGS,STX5,ASGR2,CBX8,TRIM25,PSMA6,JOSD1,NUP42,GPIHBP1,AURKA,SENP2,POMGNT2,ADAMTS2,TMEM115,SBSPON,FUCA1,SMAD2,PSMD1,ST8SIA6,GALNTL5,LMAN2,RAB3B,TRAF3,TRAPPC9,DCTN4,CHST8,PSMC1,MANEA,SUMO2,USP17L10,RNF5,PIGO,MIR711,ALPG,ALG10B,ARRB1,ANK3,ADRB2,RNF139,B3GNT6,MIA2,RING1,BRCA1,PSME1,PIGU,MGAT4A,PLET1,YOD1,KDELR1,DNAJC24,EDEM2,NUP54,STAMBPL1,BLM,NAPB,INO80C,NAGK,NSMCE4A,GFUS,NLRP3,CYLD,FOXK2,ST3GAL5,ADAMTS3,BCL10,RAB2A,RTN4RL2,COG6,SEC23A,ST3GAL1,NEGR1,SEC24A,H2BC8,PSMA1,NTNG2,MPDU1,RAB40B,MAN2A1,CAMKMT,RECK,BGLAP,NFKBIA,TAF10,USP8,MUC6,GALNT17,ADAMTS15,B3GNT7,RAB6B,ADAMTS20,DOLK,PMM2,PIGC,SEC24D,SPON1,ASGR1,UBE2K,NUP160,MUC7,UBE2D1,ADAMTS16,NUP210,PRND,DCTN5,GALNT7,RNF185,CEACAM5,OTUB2,CEACAM7,MUC21,ETFBKMT,ADAMTSL5,CFTR,PRKCSH,H2AC11,RAB27B,PSMA4,NEU1,WRN,PIAS1,COG8,BAP1,LYPD1,GBF1,ST3GAL3,PCNA,USP14,GALNT9,RAD23A,RAB4A,BMI1,RAB40C,VNN3P,PGM3,USP21,ADAMTS14,EID3,MDM4,OTUD7B,ALG3,RAB18,ALG10,NUP35,MPI,CALR,ST6GAL1,COG1,VCPKMT,TBC1D20,DPM1,SEC24C,UIMC1,UBE2G1,PTRH2,LMAN1,UBA6,HSPA8,MDC1,IZUMO1R,RAB30,TRAPPC1,INS,VDAC3,SMC3,PSMC3,PIGT,FN3K,MLEC,UBB,TGFB1,NDC1,MGAT4C,PIGG,PMM1,COPZ2,SEC22C,NUP50,SMC6,LYPD6B,TOP1,PSMD6,POMT1,RAD52,THSD7B,GALNT15,F5,PIAS2,NUP133,NRN1,RUVBL1,AMFR,TECTB,PIAS4,CDKN2A,PSMB11,BET1,H2BC3,SENP1,ST6GALNAC2,GGCX,VNN1,H2BC15,UBE2E3,TP53,SEM1,THSD1,METTL21A,CNTN5,RAB3A,PSMB8,TUSC3,GMPPB,C1GALT1,RAB37,SUMO1,RAB32,ARSI,ST3GAL4,ART3,ADAMTS12,TNKS2,CDC20,WDR20,PIGH,PIGV,RFT1,SPTBN5,BST1,CHML,RAB31,MDGA2,CTSZ,GOLGA2,INCENP,USP17L2,INO80E,GALNT16,IDE,BET1L,RAB1B,NUP43,ARF1,GATA3,MVD,PSMD12,RAB6A,CHST10,RAB35,STAM,ARF5,WAC,NUP88,GALNT18,USP34,H2BC10,F7,SEH1L,COG5,UMOD,TECTA,PTP4A2,MUC20,KDM1B,MELTF,LYPD4,FOLR1,KIN,DOHH,SAE1,ACTR5,ADAMTS1,PSMB3,ADAMTS8,SEC22B,CNIH2,USP25,TFAP2A,RAB2B,RNF123,PSCA,PSMD13,NUP93,ALPL,RAB11A,GNPNAT1,HGS,FUT8,UBE2E1,ACTR8,NAPG,PSMD9,MCFD2,RNF168,MSLN,LEO1,USP22,DPH1,MUL1,H2AC7,ESR1,FKBP8,ADAMTS13,NUP107,PHC3,PRKDC,NTNG1,NUP214,COPB1,B3GNT4,COG2,MDGA1,CANX,TDG,UBE2W,EIF5A,DYNC1LI2,SP100,PROZ,ST6GALNAC5,ST6GALNAC6,UBE2Q2,UBC,BECN1,MGAT2,CCNA1,UAP1,DYNC1LI1,TFAP2B,ADRM1,F10,KDELR2,RNF20,MAN1A1,CCNA2,PSMB2,FUT3,MIR1281,DAG1,RNF135,SPTBN2,GMDS,STAG1,NUP58,TGFA,MAVS,MUC15,MUC13,H2BC13,SRD5A3,PIGL,USP16,NUP85,OPCML,ARRB2,USP5,ADAMTS9,UBA52,RAB39A,RAB26,POLB,CALM2,ARCN1,SPON2,TMED3,USP13,H2BC4,TPR,LYPD8,RABGGTB,PSMD7,RRAGA,H2AC1,UCHL3,NGLY1,POM121C,ENGASE,PARP1,EIF5A2,THSD7A,SUMF1,CBX4,EEF2KMT,GANAB,DAD1,RTF1,H2AC8,NSMCE3,CTR9,SEC16B,RIPK2,RHOT1,SEC31A,MGAT4B,FCGR3B,SERPINA1,PROS1,THBS1,GRIA1,MUC2,LY6K,GORASP1,OTUD7A,NUP62,RPA1,SMAD3,ARSB,PSMD2,ST8SIA5,RAET1L,RAB1A,VCP,ART4,SPTA1,LYPD5,GOSR1,SAR1B,PIGQ,GALNT14,ATXN7,TRAPPC2L,DERL1,OTUD3,NSMCE2,IFIH1,RIPK1,PROC,RWDD3,GNE,B3GLCT,DYNC1H1,TFG,SPACA4,RAB42,UCHL5,ADAMTS6,NUP153,MBD5,COG4,PIGP,GALNT12,ALG14,SMAD4,LY6G6D,H2BC6,LMAN1L,B4GALT4,TADA3,PTEN,USP24,ALG12,TRAF6,MUC16,RPN2,CD52,ADAMTS4,CALM1,SPTAN1,USP4,USP7,SEC13,H2AC16,TRIM13,RAD23B,PSMB6,RPS27A,CHST4,CD109,GALNT8,RAB3C,EEF1A1,USP49,USP10,GLB1,DDB2,SYVN1,B4GALT3,RAB20,RAET1G,AREG,L3MBTL2,MUC4,USP42,ST6GALNAC1,RNF146,SCMH1,HERC2,FOXK1,CGA,GOLGB1,ADAMTS17,TGFBR1,PCGF2,UBE2G2,RNF144A,DCTN6,ADAMTSL2,DPM2,PHC2,UBE2B,H2AC4,NFRKB,LY6H,ADAMTSL4,USP33,UBE2L3
R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis	0.952654158742668	-0.0485033386280095	40	32	0.00354217400929821	9034	10285	10693,83752,84261,22803,55135,26190,26270,2629,8877,63971,898,7157,26272,9134,10528,22948,26330,26224,11328,26985,26234,6468,10564,55294,10576,10238,10694,10575,6774,3801,8841,10574	CCT6B,LONP2,FBXW9,XRN2,WRAP53,FBXW2,FBXO6,GBA1,SPHK1,KIF13A,CCNE1,TP53,FBXO4,CCNE2,NOP56,CCT5,GAPDHS,FBXL3,FKBP9,AP3M1,FBXL5,FBXW4,ARFGEF2,FBXW7,CCT2,DCAF7,CCT8,CCT4,STAT3,KIFC3,HDAC3,CCT7
R-HSA-425397	Transport of vitamins, nucleosides, and related molecules	0.952654158742668	-0.0485033386280095	40	32	0.00354217400929821	9034	10285	213,55315,28965,28232,11309,28231,10559,353189,3177,28234,6578,347734,2030,9153,23169,100616124,9197,376497,222962,64078,23443,84912,8884,551,55343,53919,11046,10999,10599,9154,6579,51000	ALB,SLC29A3,SLC27A6,SLCO3A1,SLCO2B1,SLCO4A1,SLC35A1,SLCO4C1,SLC29A2,SLCO1B3,SLCO2A1,SLC35B2,SLC29A1,SLC28A2,SLC35D1,MIR4647,SLC33A1,SLC27A1,SLC29A4,SLC28A3,SLC35A3,SLC35B4,SLC5A6,AVP,SLC35C1,SLCO1C1,SLC35D2,SLC27A4,SLCO1B1,SLC28A1,SLCO1A2,SLC35B3
R-HSA-75955	RNA Polymerase II Transcription Elongation	0.953013995417809	-0.048125689792737	65	53	0.00586672570290016	9034	10285	2968,5430,6917,100506888,51497,5433,27125,2071,54623,4298,9150,6829,9646,55677,11198,2967,2965,2963,8178,6924,23168,4686,4300,2068,22916,4331,5431,5432,5439,162699,79577,85403,51224,6923,5440,905,100126332,404672,55840,7936,1022,6827,2962,100302242,5434,902,8812,7469,5441,904,6749,123169,6921	GTF2H4,POLR2A,TCEA1,ELOA3DP,NELFCD,POLR2D,AFF4,ERCC3,PAF1,MLLT1,CTDP1,SUPT5H,CTR9,IWS1,SUPT16H,GTF2H3,GTF2H1,GTF2F2,ELL,ELOA,RTF1,NCBP1,MLLT3,ERCC2,NCBP2,MNAT1,POLR2B,POLR2C,POLR2J,ELOA3P,CDC73,EAF1,ELOA2,ELOB,POLR2K,CCNT2,MIR943,GTF2H5,EAF2,NELFE,CDK7,SUPT4H1,GTF2F1,MIR1236,POLR2E,CCNH,CCNK,NELFA,POLR2L,CCNT1,SSRP1,LEO1,ELOC
R-HSA-112382	Formation of RNA Pol II elongation complex	0.953013995417809	-0.048125689792737	65	53	0.00586672570290016	9034	10285	4300,2068,22916,5431,4331,2963,8178,6924,4686,23168,54623,4298,2071,6829,9646,9150,55677,11198,2965,2967,2968,5430,6917,100506888,51497,27125,5433,5441,904,7469,8812,6749,123169,6921,6827,5434,902,2962,100302242,404672,100126332,7936,55840,1022,162699,5432,5439,85403,51224,79577,6923,905,5440	MLLT3,ERCC2,NCBP2,POLR2B,MNAT1,GTF2F2,ELL,ELOA,NCBP1,RTF1,PAF1,MLLT1,ERCC3,SUPT5H,CTR9,CTDP1,IWS1,SUPT16H,GTF2H1,GTF2H3,GTF2H4,POLR2A,TCEA1,ELOA3DP,NELFCD,AFF4,POLR2D,POLR2L,CCNT1,NELFA,CCNK,SSRP1,LEO1,ELOC,SUPT4H1,POLR2E,CCNH,GTF2F1,MIR1236,GTF2H5,MIR943,NELFE,EAF2,CDK7,ELOA3P,POLR2C,POLR2J,EAF1,ELOA2,CDC73,ELOB,CCNT2,POLR2K
R-HSA-5083632	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	0.953258717217742	-0.0478689355522172	17	13	0.0014390081912774	9034	10285	143662,4583,200958,4588,394263,4589,56667,118430,727897,10071,94025,140453,4585	MUC15,MUC2,MUC20,MUC6,MUC21,MUC7,MUC13,MUCL1,MUC5B,MUC12,MUC16,MUC17,MUC4
R-HSA-5083625	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	0.953258717217742	-0.0478689355522172	17	13	0.0014390081912774	9034	10285	56667,4589,394263,4588,200958,4583,143662,4585,140453,10071,94025,727897,118430	MUC13,MUC7,MUC21,MUC6,MUC20,MUC2,MUC15,MUC4,MUC17,MUC12,MUC16,MUC5B,MUCL1
R-HSA-70221	Glycogen breakdown (glycogenolysis)	0.953258717217742	-0.0478689355522172	17	13	0.0014390081912774	9034	10285	5236,5257,5834,55276,2548,2992,808,178,5836,805,5261,5837,801	PGM1,PHKB,PYGB,PGM2,GAA,GYG1,CALM3,AGL,PYGL,CALM2,PHKG2,PYGM,CALM1
R-HSA-5083636	Defective GALNT12 causes colorectal cancer 1 (CRCS1)	0.953258717217742	-0.0478689355522172	17	13	0.0014390081912774	9034	10285	727897,118430,94025,10071,140453,4585,143662,200958,4583,4588,394263,4589,56667	MUC5B,MUCL1,MUC16,MUC12,MUC17,MUC4,MUC15,MUC20,MUC2,MUC6,MUC21,MUC7,MUC13
R-HSA-76061	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.953911934573738	-0.0471839235624143	28	22	0.00243524463139252	9034	10285	2975,55718,27297,112495,5434,10622,9330,2971,2976,51728,5441,9329,55703,51082,5440,9533,661,11128,10623,9328,171568,84265	GTF3C1,POLR3E,CRCP,GTF3C6,POLR2E,POLR3G,GTF3C3,GTF3A,GTF3C2,POLR3K,POLR2L,GTF3C4,POLR3B,POLR1D,POLR2K,POLR1C,POLR3D,POLR3A,POLR3C,GTF3C5,POLR3H,POLR3GL
R-HSA-76071	RNA Polymerase III Transcription Initiation From Type 3 Promoter	0.953911934573738	-0.0471839235624143	28	22	0.00243524463139252	9034	10285	5440,51082,5451,661,9533,6619,10623,11128,84265,171568,6617,5434,27297,55718,7702,10302,10622,51728,55703,6618,5441,55290	POLR2K,POLR1D,POU2F1,POLR3D,POLR1C,SNAPC3,POLR3C,POLR3A,POLR3GL,POLR3H,SNAPC1,POLR2E,CRCP,POLR3E,ZNF143,SNAPC5,POLR3G,POLR3K,POLR3B,SNAPC2,POLR2L,BRF2
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	0.954645732899143	-0.046414967639239	52	42	0.0046491033872039	9034	10285	100126332,2071,404672,9150,6829,11198,7936,2967,1022,2965,5430,5439,2968,5432,162699,100506888,6917,51224,6923,51497,5440,5433,905,8812,7469,904,5441,6749,2068,6921,22916,4331,5431,2963,6827,6924,8178,100302242,2962,902,5434,4686	MIR943,ERCC3,GTF2H5,CTDP1,SUPT5H,SUPT16H,NELFE,GTF2H3,CDK7,GTF2H1,POLR2A,POLR2J,GTF2H4,POLR2C,ELOA3P,ELOA3DP,TCEA1,ELOA2,ELOB,NELFCD,POLR2K,POLR2D,CCNT2,CCNK,NELFA,CCNT1,POLR2L,SSRP1,ERCC2,ELOC,NCBP2,MNAT1,POLR2B,GTF2F2,SUPT4H1,ELOA,ELL,MIR1236,GTF2F1,CCNH,POLR2E,NCBP1
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	0.955539066009476	-0.045479630727364	104	86	0.00951959264998893	9034	10285	23495,356,5704,5698,6500,5696,10213,7292,7124,5720,10673,5714,5691,4982,5695,8740,8741,5693,5690,10913,115650,4791,8454,5702,5686,4049,943,7314,5685,5719,7133,5687,5708,8945,5711,9861,7293,5694,4050,9020,9966,5706,1147,5717,5682,5715,5718,608,5701,329,7187,9039,330,6233,8718,5707,128178,23291,8742,8792,5684,122706,8600,5699,8784,5692,970,7311,10197,5700,9491,8744,23198,5713,7132,7316,939,7979,944,3604,4055,5971,5710,143471,8995,958	TNFRSF13B,FASLG,PSMC4,PSMB9,SKP1,PSMB8,PSMD14,TNFSF4,TNF,PSME1,TNFSF13B,PSMD8,PSMB3,TNFRSF11B,PSMB7,TNFSF14,TNFSF13,PSMB5,PSMB2,EDAR,TNFRSF13C,NFKB2,CUL1,PSMC3,PSMA5,LTA,TNFRSF8,UBB,PSMA4,PSMD13,TNFRSF1B,PSMA6,PSMD2,BTRC,PSMD5,PSMD6,TNFRSF4,PSMB6,LTB,MAP3K14,TNFSF15,PSMC6,CHUK,PSMD11,PSMA1,PSMD9,PSMD12,TNFRSF17,PSMC2,BIRC2,TRAF3,UBA3,BIRC3,RPS27A,TNFRSF25,PSMD1,EDARADD,FBXW11,TNFSF12,TNFRSF11A,PSMA3,PSMB11,TNFSF11,PSMB10,TNFRSF18,PSMB4,CD70,UBA52,PSME3,PSMC1,PSMF1,TNFSF9,PSME4,PSMD7,TNFRSF1A,UBC,CD27,SEM1,TNFSF8,TNFRSF9,LTBR,RELB,PSMD4,PSMA8,TNFSF18,CD40
R-HSA-6794361	Interactions of neurexins and neuroligins at synapses	0.956189523168652	-0.0447991395865624	58	47	0.00520256807615674	9034	10285	8825,2911,2915,2906,9378,9229,2036,9546,6812,2905,143425,2035,2037,28988,2903,22871,1740,9455,9066,26037,127833,6857,57555,9456,22839,57596,2904,26045,80059,58512,321,22941,9369,320,55327,9379,9228,341359,23136,91683,1742,10611,347731,9454,57669,347730,50944	LIN7A,GRM1,GRM5,GRIN2D,NRXN1,DLGAP1,EPB41L1,APBA3,STXBP1,GRIN2C,SYT9,EPB41,EPB41L2,DBNL,GRIN2A,NLGN1,DLG2,HOMER2,SYT7,SIPA1L1,SYT2,SYT1,NLGN2,HOMER1,DLGAP4,BEGAIN,GRIN2B,LRRTM2,LRRTM4,DLGAP3,APBA2,SHANK2,NRXN3,APBA1,LIN7C,NRXN2,DLGAP2,SYT10,EPB41L3,SYT12,DLG4,PDLIM5,LRRTM3,HOMER3,EPB41L5,LRRTM1,SHANK1
R-HSA-5362768	Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	0.956189523168652	-0.0447991395865624	58	47	0.00520256807615674	9034	10285	5714,6400,5691,5695,5704,5698,5696,10213,5720,7314,5685,5719,5687,6469,5693,5690,5702,5686,5718,10956,5701,7415,6233,5707,5708,5711,9861,5694,5706,5717,5682,5715,5713,23198,7316,7979,5710,143471,5684,122706,5699,5692,7311,10197,5700,9491,84447	PSMD8,SEL1L,PSMB3,PSMB7,PSMC4,PSMB9,PSMB8,PSMD14,PSME1,UBB,PSMA4,PSMD13,PSMA6,SHH,PSMB5,PSMB2,PSMC3,PSMA5,PSMD12,OS9,PSMC2,VCP,RPS27A,PSMD1,PSMD2,PSMD5,PSMD6,PSMB6,PSMC6,PSMD11,PSMA1,PSMD9,PSMD7,PSME4,UBC,SEM1,PSMD4,PSMA8,PSMA3,PSMB11,PSMB10,PSMB4,UBA52,PSME3,PSMC1,PSMF1,SYVN1
R-HSA-2660825	Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.956922505522605	-0.0440328672733612	7	5	0.000553464688952845	9034	10285	182,3714,54567,102,6868	JAG1,JAG2,DLL4,ADAM10,ADAM17
R-HSA-162791	Attachment of GPI anchor to uPAR	0.956922505522605	-0.0440328672733612	7	5	0.000553464688952845	9034	10285	5329,128869,80055,10026,51604	PLAUR,PIGU,PGAP1,PIGK,PIGT
R-HSA-447043	Neurofascin interactions	0.956922505522605	-0.0440328672733612	7	5	0.000553464688952845	9034	10285	4897,23114,6386,1272,286	NRCAM,NFASC,SDCBP,CNTN1,ANK1
R-HSA-2660826	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	0.956922505522605	-0.0440328672733612	7	5	0.000553464688952845	9034	10285	3714,6868,54567,102,182	JAG2,ADAM17,DLL4,ADAM10,JAG1
R-HSA-171319	Telomere Extension By Telomerase	0.956922505522605	-0.0440328672733612	7	5	0.000553464688952845	9034	10285	55651,55135,7015,10856,8607	NHP2,WRAP53,TERT,RUVBL2,RUVBL1
R-HSA-8873719	RAB geranylgeranylation	0.957914495663299	-0.0429967579556251	64	52	0.00575603276510959	9034	10285	5876,64284,115273,8073,55647,22931,5878,51762,4218,51715,51560,23682,7879,11021,57111,54734,25837,57799,51552,8934,5870,5867,5865,5861,115827,5873,23011,10966,401258,5868,201475,81876,9545,53917,9609,8766,5874,1122,5862,11031,5869,401409,84932,27314,5872,339122,10890,83452,326624,57403,10981,5864	RABGGTB,RAB17,RAB42,PTP4A2,RAB20,RAB18,RAB5C,RAB8B,RAB8A,RAB23,RAB6B,RAB38,RAB7A,RAB35,RAB25,RAB39A,RAB26,RAB40C,RAB14,RAB29,RAB6A,RAB4A,RAB3B,RAB1A,RAB3C,RAB27A,RAB21,RAB40B,RAB44,RAB5A,RAB12,RAB1B,RAB3D,RAB24,RAB36,RAB11A,RAB27B,CHML,RAB2A,RAB31,RAB5B,RAB19,RAB2B,RAB30,RAB13,RAB43,RAB10,RAB33B,RAB37,RAB22A,RAB32,RAB3A
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	0.958219205007194	-0.0426787119378997	110	91	0.0100730573389418	9034	10285	7321,6195,1021,8354,4790,890,8362,6196,8900,128312,8349,1051,8359,5594,8344,64682,3020,3569,3013,8358,8968,653604,11065,8360,7324,8343,8339,1031,5970,8367,8365,126961,3018,8341,8370,8353,5598,996,7316,121504,8366,3552,8348,1029,8334,1017,2353,3021,55766,51433,1027,1019,8697,3012,3576,1026,7314,51343,8335,10919,8352,3490,119504,1032,51434,723790,29945,10393,8364,6774,6233,25906,8355,8970,8357,3725,8340,8363,94239,8350,1030,8345,8347,8361,51529,7311,5595,8346,8368,3015,3017	UBE2D1,RPS6KA1,CDK6,H3C11,NFKB1,CCNA2,H4C12,RPS6KA2,CCNA1,H2BC26,H2BC21,CEBPB,H4C1,MAPK1,H2BC6,ANAPC1,H3-3A,IL6,H2AC7,H3C2,H3C7,H3C13,UBE2C,H4C4,UBE2E1,H2BC7,H2BC8,CDKN2C,RELA,H4C5,H4C8,H3C14,H2BC3,H2BC15,H4C14,H3C6,MAPK7,CDC27,UBC,H4C16,H4C2,IL1A,H2BC17,CDKN2A,H2AC6,CDK2,FOS,H3-3B,H2AJ,ANAPC5,CDKN1B,CDK4,CDC23,H2AC8,CXCL8,CDKN1A,UBB,FZR1,H2AC4,EHMT2,H3C3,IGFBP7,ANAPC16,CDKN2D,ANAPC7,H2AC19,ANAPC4,ANAPC10,H4C3,STAT3,RPS27A,ANAPC15,H3C8,H2BC11,H3C10,JUN,H2BC13,H4C11,H2AZ2,H3C1,CDKN2B,H2BC9,H2BC4,H4C6,ANAPC11,UBA52,MAPK3,H2BC10,H4C13,H2AZ1,H2BC5
R-HSA-190704	Oligomerization of connexins into connexons	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	2706,2697	GJB2,GJA1
R-HSA-5357572	Lysosomal glycogen catabolism	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	2992,2548	GYG1,GAA
R-HSA-190827	Transport of connexins along the secretory pathway	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	2697,2706	GJA1,GJB2
R-HSA-1307965	betaKlotho-mediated ligand binding	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	9965,2264	FGF19,FGFR4
R-HSA-427589	Type II Na+/Pi cotransporters	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	10568,6569	SLC34A2,SLC34A1
R-HSA-379398	Enzymatic degradation of Dopamine by monoamine oxidase	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	100616414,1312	MIR4761,COMT
R-HSA-380615	Serotonin clearance from the synaptic cleft	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	217,6532	ALDH2,SLC6A4
R-HSA-5250971	Toxicity of botulinum toxin type C (BoNT/C)	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	6616,112755	SNAP25,STX1B
R-HSA-379397	Enzymatic degradation of dopamine by COMT	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	100616414,1312	MIR4761,COMT
R-HSA-880009	Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	0.959238561251851	-0.0416154746049848	3	2	0.000221385875581138	9034	10285	137872,79944	ADHFE1,L2HGDH
R-HSA-76066	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.961540427172427	-0.0392186688960472	27	21	0.00232455169360195	9034	10285	112495,27297,2975,55718,5440,5434,51082,9330,10622,9533,661,11128,2976,51728,9328,10623,9329,5441,55703,84265,171568	GTF3C6,CRCP,GTF3C1,POLR3E,POLR2K,POLR2E,POLR1D,GTF3C3,POLR3G,POLR1C,POLR3D,POLR3A,GTF3C2,POLR3K,GTF3C5,POLR3C,GTF3C4,POLR2L,POLR3B,POLR3GL,POLR3H
R-HSA-418038	Nucleotide-like (purinergic) receptors	0.963457346672481	-0.0372270612591739	16	12	0.00132831525348683	9034	10285	135,5031,5028,64805,10161,53829,5029,136,5032,9934,140,134	ADORA2A,P2RY6,P2RY1,P2RY12,LPAR6,P2RY13,P2RY2,ADORA2B,P2RY11,P2RY14,ADORA3,ADORA1
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	0.963468862114443	-0.0372151091232707	82	67	0.00741642683196812	9034	10285	114791,984,5577,1639,80321,7531,85378,22919,5048,7277,23354,121441,5347,4926,203068,22995,9814,95681,1778,55722,93323,5566,79441,4957,27175,22897,1781,54801,9662,80254,10806,115106,54820,5108,22981,1454,10142,80184,4751,3320,5518,11190,728642,11258,983,55125,7846,10121,9793,54930,9702,84131,1453,10382,22994,11064,23332,55755,79959,891,10733,7532,7840,10426,10540,55835,8655	TUBGCP5,CDK11B,PRKAR2B,DCTN1,CEP70,YWHAE,TUBGCP6,MAPRE1,PAFAH1B1,TUBA4A,HAUS5,NEDD1,PLK1,NUMA1,TUBB,CEP152,SFI1,CEP41,DYNC1H1,CEP72,HAUS8,PRKACA,HAUS3,ODF2,TUBG2,CEP164,DYNC1I2,HAUS6,CEP135,CEP63,SDCCAG8,HAUS1,NDE1,PCM1,NINL,CSNK1E,AKAP9,CEP290,NEK2,HSP90AA1,PPP2R1A,CEP250,CDK11A,DCTN3,CDK1,CEP192,TUBA1A,ACTR1A,CKAP5,HAUS4,CEP57,CEP78,CSNK1D,TUBB4A,CEP131,CNTRL,CLASP1,CDK5RAP2,CEP76,CCNB1,PLK4,YWHAG,ALMS1,TUBGCP3,DCTN2,CENPJ,DYNLL1
R-HSA-380287	Centrosome maturation	0.963468862114443	-0.0372151091232707	82	67	0.00741642683196812	9034	10285	54820,5108,22981,1454,10142,93323,5566,79441,4957,9662,22897,27175,54801,1781,80254,10806,115106,23354,7277,4926,121441,5347,9814,22995,95681,203068,1778,55722,984,114791,1639,5577,80321,5048,85378,7531,22919,10733,7532,7840,55835,10426,10540,8655,11064,23332,79959,891,55755,7846,10121,9793,9702,54930,22994,1453,84131,10382,80184,4751,5518,11190,3320,728642,11258,983,55125	NDE1,PCM1,NINL,CSNK1E,AKAP9,HAUS8,PRKACA,HAUS3,ODF2,CEP135,CEP164,TUBG2,HAUS6,DYNC1I2,CEP63,SDCCAG8,HAUS1,HAUS5,TUBA4A,NUMA1,NEDD1,PLK1,SFI1,CEP152,CEP41,TUBB,DYNC1H1,CEP72,CDK11B,TUBGCP5,DCTN1,PRKAR2B,CEP70,PAFAH1B1,TUBGCP6,YWHAE,MAPRE1,PLK4,YWHAG,ALMS1,CENPJ,TUBGCP3,DCTN2,DYNLL1,CNTRL,CLASP1,CEP76,CCNB1,CDK5RAP2,TUBA1A,ACTR1A,CKAP5,CEP57,HAUS4,CEP131,CSNK1D,CEP78,TUBB4A,CEP290,NEK2,PPP2R1A,CEP250,HSP90AA1,CDK11A,DCTN3,CDK1,CEP192
R-HSA-937039	IRAK1 recruits IKK complex	0.964431235284136	-0.0362167448917139	11	8	0.000885543502324552	9034	10285	1147,7334,7335,246330,7189,57162,57161,3551	CHUK,UBE2N,UBE2V1,PELI3,TRAF6,PELI1,PELI2,IKBKB
R-HSA-2470946	Cohesin Loading onto Chromatin	0.964431235284136	-0.0362167448917139	11	8	0.000885543502324552	9034	10285	9126,23383,10274,25836,23063,23047,23244,5885	SMC3,MAU2,STAG1,NIPBL,WAPL,PDS5B,PDS5A,RAD21
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	0.964431235284136	-0.0362167448917139	11	8	0.000885543502324552	9034	10285	1147,7334,57161,7189,57162,246330,7335,3551	CHUK,UBE2N,PELI2,TRAF6,PELI1,PELI3,UBE2V1,IKBKB
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	0.964431235284136	-0.0362167448917139	11	8	0.000885543502324552	9034	10285	114791,121441,10426,4926,27175,85378,891,983	TUBGCP5,NEDD1,TUBGCP3,NUMA1,TUBG2,TUBGCP6,CCNB1,CDK1
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	0.964933388225554	-0.0356962077712155	50	40	0.00442771751162276	9034	10285	2068,6749,5441,904,7469,4331,5431,22916,6921,6827,2963,4686,5434,902,2962,100302242,8178,6924,6829,9150,404672,2071,100126332,2965,2967,1022,7936,11198,51224,6917,100506888,162699,2968,5432,5430,5439,5433,5440,51497,6923	ERCC2,SSRP1,POLR2L,CCNT1,NELFA,MNAT1,POLR2B,NCBP2,ELOC,SUPT4H1,GTF2F2,NCBP1,POLR2E,CCNH,GTF2F1,MIR1236,ELL,ELOA,SUPT5H,CTDP1,GTF2H5,ERCC3,MIR943,GTF2H1,GTF2H3,CDK7,NELFE,SUPT16H,ELOA2,TCEA1,ELOA3DP,ELOA3P,GTF2H4,POLR2C,POLR2A,POLR2J,POLR2D,POLR2K,NELFCD,ELOB
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	0.964933388225554	-0.0356962077712155	50	40	0.00442771751162276	9034	10285	2068,6749,5441,904,7469,5431,4331,22916,6921,6827,2963,4686,5434,902,2962,100302242,8178,6924,6829,9150,404672,2071,100126332,2965,2967,1022,11198,7936,51224,6917,100506888,162699,5432,2968,5439,5430,5433,5440,51497,6923	ERCC2,SSRP1,POLR2L,CCNT1,NELFA,POLR2B,MNAT1,NCBP2,ELOC,SUPT4H1,GTF2F2,NCBP1,POLR2E,CCNH,GTF2F1,MIR1236,ELL,ELOA,SUPT5H,CTDP1,GTF2H5,ERCC3,MIR943,GTF2H1,GTF2H3,CDK7,SUPT16H,NELFE,ELOA2,TCEA1,ELOA3DP,ELOA3P,POLR2C,GTF2H4,POLR2J,POLR2A,POLR2D,POLR2K,NELFCD,ELOB
R-HSA-167169	HIV Transcription Elongation	0.964933388225554	-0.0356962077712155	50	40	0.00442771751162276	9034	10285	100302242,2962,902,4686,5434,6924,8178,6827,2963,4331,5431,6921,22916,6749,2068,7469,904,5441,5440,5433,6923,51497,100506888,6917,51224,5439,5430,2968,5432,162699,2967,1022,2965,7936,11198,9150,6829,100126332,2071,404672	MIR1236,GTF2F1,CCNH,NCBP1,POLR2E,ELOA,ELL,SUPT4H1,GTF2F2,MNAT1,POLR2B,ELOC,NCBP2,SSRP1,ERCC2,NELFA,CCNT1,POLR2L,POLR2K,POLR2D,ELOB,NELFCD,ELOA3DP,TCEA1,ELOA2,POLR2J,POLR2A,GTF2H4,POLR2C,ELOA3P,GTF2H3,CDK7,GTF2H1,NELFE,SUPT16H,CTDP1,SUPT5H,MIR943,ERCC3,GTF2H5
R-HSA-2024096	HS-GAG degradation	0.965347825796041	-0.0352668013470684	21	16	0.0017710870046491	9034	10285	2720,2262,6382,375790,3425,6383,2990,10082,6448,60495,6385,79411,10855,3339,9672,2817	GLB1,GPC5,SDC1,AGRN,IDUA,SDC2,GUSB,GPC6,SGSH,HPSE2,SDC4,GLB1L,HPSE,HSPG2,SDC3,GPC1
R-HSA-73863	RNA Polymerase I Transcription Termination	0.96594590797049	-0.034647442227209	32	25	0.00276732344476422	9034	10285	25885,9014,902,221830,5434,5441,79101,10849,9015,2068,7270,84172,4331,64425,9533,284119,2968,7343,51082,5440,404672,2071,2965,1022,2967	POLR1A,TAF1B,CCNH,POLR1F,POLR2E,POLR2L,TAF1D,POLR1G,TAF1A,ERCC2,TTF1,POLR1B,MNAT1,POLR1E,POLR1C,CAVIN1,GTF2H4,UBTF,POLR1D,POLR2K,GTF2H5,ERCC3,GTF2H1,CDK7,GTF2H3
R-HSA-2408522	Selenoamino acid metabolism	0.966017940627458	-0.0345728728639644	121	100	0.0110692937790569	9034	10285	118672,6144,6138,200916,7296,6159,9061,6124,6235,9045,3176,6133,6205,6230,11185,6207,6129,6154,6206,4143,25873,6166,875,6227,6165,6167,3921,4837,6128,5917,6202,6160,6139,6175,6143,9255,6232,4141,6176,27232,140801,6123,51520,6136,191,23521,6164,2936,6210,6231,7311,6224,6152,6137,79048,6135,6201,6233,6169,6130,9521,9060,6142,6189,6208,6122,6194,4736,6229,6217,6234,51065,6125,2058,1615,6146,7965,6168,6181,6228,51540,3376,6161,6188,6209,6157,60678,3735,51091,6155,5859,9349,6301,6204,6223,116832,51121,11224,6156,1491	PSTK,RPL21,RPL15,RPL22L1,TXNRD1,RPL29,PAPSS1,RPL4,RPS29,RPL14,HNMT,RPL9,RPS11,RPS25,INMT,RPS13,RPL7,RPL26,RPS12,MAT1A,RPL36,RPL36AL,CBS,RPS21,RPL35A,RPL37,RPSA,NNMT,RPL6,RARS1,RPS8,RPL31,RPL17,RPLP0,RPL19,AIMP1,RPS27,MARS1,RPLP1,GNMT,RPL10L,RPL3L,LARS1,RPL12,AHCY,RPL13A,RPL34,GSR,RPS15A,RPS26,UBA52,RPS20,RPL24,RPL13,SECISBP2,RPL11,RPS7,RPS27A,RPL38,RPL7A,EEF1E1,PAPSS2,RPL18A,RPS3A,RPS14,RPL3,RPS6,RPL10A,RPS24,RPS16,RPS28,RPS27L,RPL5,EPRS1,DARS1,RPL22,AIMP2,RPL37A,RPLP2,RPS23,SCLY,IARS1,RPL32,RPS3,RPS15,RPL27A,EEFSEC,KARS1,SEPSECS,RPL27,QARS1,RPL23,SARS1,RPS10,RPS19,RPL39L,RPL26L1,RPL35,RPL30,CTH
R-HSA-6790901	rRNA modification in the nucleus and cytosol	0.966617725611139	-0.0339521816354885	62	50	0.00553464688952845	9034	10285	51504,25926,84916,10199,9277,54555,23160,57647,27042,11103,51077,55623,65083,5822,9790,55127,79050,10528,51118,25879,57050,2091,27340,84128,8602,55272,88745,6201,22984,55226,55813,11056,51096,92856,10607,10171,6208,6194,27292,9136,51202,9724,27341,55651,84135,54433,51602,4809,134430,10885	TRMT112,NOL11,UTP4,MPHOSPH10,WDR46,DDX49,WDR43,DHX37,UTP25,KRR1,FCF1,THUMPD1,NOL6,PWP2,BMS1,HEATR1,NOC4L,NOP56,UTP11,DCAF13,UTP3,FBL,UTP20,WDR75,NOP14,IMP3,RRP36,RPS7,PDCD11,NAT10,UTP6,DDX52,UTP18,IMP4,TBL3,RCL1,RPS14,RPS6,DIMT1,RRP9,DDX47,UTP14C,RRP7A,NHP2,UTP15,GAR1,NOP58,SNU13,WDR36,WDR3
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	0.968292535511162	-0.0322210312540554	26	20	0.00221385875581138	9034	10285	9099,10616,7128,23118,1147,7124,8737,10454,8717,27005,56957,330,6885,3551,10399,7132,329,7375,7185,1540	USP2,RBCK1,TNFAIP3,TAB2,CHUK,TNF,RIPK1,TAB1,TRADD,USP21,OTUD7B,BIRC3,MAP3K7,IKBKB,RACK1,TNFRSF1A,BIRC2,USP4,TRAF1,CYLD
R-HSA-389960	Formation of tubulin folding intermediates by CCT/TriC	0.968292535511162	-0.0322210312540554	26	20	0.00221385875581138	9034	10285	51807,7280,112714,7278,81027,22948,10376,10693,10574,10694,7277,79861,10575,7846,10381,10382,84617,84790,10576,347733	TUBA8,TUBB2A,TUBA3E,TUBA3C,TUBB1,CCT5,TUBA1B,CCT6B,CCT7,CCT8,TUBA4A,TUBAL3,CCT4,TUBA1A,TUBB3,TUBB4A,TUBB6,TUBA1C,CCT2,TUBB2B
R-HSA-5578749	Transcriptional regulation by small RNAs	0.970535947549529	-0.0299068368225391	106	87	0.0096302855877795	9034	10285	723790,10526,79023,8364,8352,55706,9688,8335,5433,23165,100101267,5431,3021,53371,55766,27161,3012,4927,8346,3017,8368,3015,81929,8350,94239,5439,129401,8347,7175,8345,8361,8357,5441,8355,8970,8340,348995,8363,79902,5434,8344,3020,8359,5901,11097,5430,9818,8362,128312,5903,8349,23511,23279,27327,26523,9972,23225,8354,121504,8366,8348,8334,9883,8021,8365,126961,3018,8367,9631,8086,5432,8370,8341,8353,5440,4928,10762,8360,8339,23636,8343,3013,8358,55746,8968,57122,653604	H2AC19,IPO8,NUP37,H4C3,H3C3,NDC1,NUP93,H2AC4,POLR2D,NUP205,POM121C,POLR2B,H3-3B,NUP54,H2AJ,AGO2,H2AC8,NUP88,H2BC10,H2BC5,H4C13,H2AZ1,SEH1L,H3C1,H2AZ2,POLR2J,NUP35,H2BC4,TPR,H2BC9,H4C6,H3C10,POLR2L,H3C8,H2BC11,H2BC13,NUP43,H4C11,NUP85,POLR2E,H2BC6,H3-3A,H4C1,RAN,NUP42,POLR2A,NUP58,H4C12,H2BC26,RANBP2,H2BC21,NUP188,NUP160,TNRC6A,AGO1,NUP153,NUP210,H3C11,H4C16,H4C2,H2BC17,H2AC6,POM121,NUP214,H4C8,H3C14,H2BC3,H4C5,NUP155,AAAS,POLR2C,H4C14,H2BC15,H3C6,POLR2K,NUP98,NUP50,H4C4,H2BC8,NUP62,H2BC7,H2AC7,H3C2,NUP133,H3C7,NUP107,H3C13
R-HSA-168255	Influenza Life Cycle	0.971289049680483	-0.029131172517272	146	121	0.0133938454726588	9034	10285	6166,25873,11097,5430,5901,9818,6227,6167,6165,3921,3320,6128,6202,6160,6143,23225,9972,6139,6175,6232,6176,5903,6123,23511,140801,23279,9631,821,6144,5432,8086,4928,5440,3836,6138,200916,6159,6124,3837,6235,9045,8021,9883,2962,6133,55746,6207,57122,6230,6205,10762,23636,6129,6154,6206,6234,6125,51065,9688,55706,5433,6146,6181,6168,6228,79023,6209,6188,2926,6161,1211,53371,6155,2963,6157,9349,3843,7514,1213,116832,6223,6204,100101267,23165,6156,51121,11224,5431,81929,23521,5439,6136,7175,811,129401,6210,6164,7311,6231,6224,4927,6135,6137,6152,6169,6233,6201,79902,6130,6142,5434,6208,6189,6122,5441,348995,4736,6194,6217,5611,6229	RPL36AL,RPL36,NUP42,POLR2A,RAN,NUP58,RPS21,RPL37,RPL35A,RPSA,HSP90AA1,RPL6,RPS8,RPL31,RPL19,NUP210,NUP153,RPL17,RPLP0,RPS27,RPLP1,RANBP2,RPL3L,NUP188,RPL10L,NUP160,NUP155,CANX,RPL21,POLR2C,AAAS,NUP98,POLR2K,KPNA1,RPL15,RPL22L1,RPL29,RPL4,KPNB1,RPS29,RPL14,NUP214,POM121,GTF2F1,RPL9,NUP133,RPS13,NUP107,RPS25,RPS11,NUP50,NUP62,RPL7,RPL26,RPS12,RPS28,RPL5,RPS27L,NUP93,NDC1,POLR2D,RPL22,RPLP2,RPL37A,RPS23,NUP37,RPS15,RPS3,GRSF1,RPL32,CLTA,NUP54,RPL27,GTF2F2,RPL27A,RPL23,IPO5,XPO1,CLTC,RPL39L,RPS19,RPS10,POM121C,NUP205,RPL30,RPL26L1,RPL35,POLR2B,SEH1L,RPL13A,POLR2J,RPL12,TPR,CALR,NUP35,RPS15A,RPL34,UBA52,RPS26,RPS20,NUP88,RPL11,RPL13,RPL24,RPL38,RPS27A,RPS7,NUP85,RPL7A,RPL18A,POLR2E,RPS14,RPS3A,RPL3,POLR2L,NUP43,RPL10A,RPS6,RPS16,DNAJC3,RPS24
R-HSA-73772	RNA Polymerase I Promoter Escape	0.97152385631918	-0.0288894542961141	31	24	0.00265663050697365	9034	10285	2071,404672,2967,1022,2965,2968,54700,9533,5440,51082,7343,84172,9015,2068,10849,79101,5441,64425,4331,25885,221830,5434,902,9014	ERCC3,GTF2H5,GTF2H3,CDK7,GTF2H1,GTF2H4,RRN3,POLR1C,POLR2K,POLR1D,UBTF,POLR1B,TAF1A,ERCC2,POLR1G,TAF1D,POLR2L,POLR1E,MNAT1,POLR1A,POLR1F,POLR2E,CCNH,TAF1B
R-HSA-390466	Chaperonin-mediated protein folding	0.971660207202261	-0.0287491167070368	99	81	0.00896612796103609	9034	10285	7280,8877,2780,51807,84261,55135,22803,7278,2783,10693,1459,7277,2791,2771,10381,7157,406974,898,5203,63971,84790,2786,26234,6468,2770,2790,112714,81027,2793,2773,2788,26330,5201,22948,60,2787,8841,3801,10575,6774,10238,10694,2781,10576,2782,26270,2629,26190,6000,8786,83752,10376,51764,7846,9628,59345,84617,8787,10528,10382,9134,26272,10681,10564,1457,26985,2779,2792,11328,26224,2784,55970,10574,346562,54331,79861,94235,5082,347733,5204,55294	TUBB2A,SPHK1,GNAT2,TUBA8,FBXW9,WRAP53,XRN2,TUBA3C,GNB2,CCT6B,CSNK2A2,TUBA4A,GNG11,GNAI2,TUBB3,TP53,MIR197,CCNE1,PFDN4,KIF13A,TUBA1C,GNG4,FBXL5,FBXW4,GNAI1,GNG10,TUBA3E,TUBB1,GNGT2,GNAI3,GNG7,GAPDHS,PFDN1,CCT5,ACTB,GNG5,HDAC3,KIFC3,CCT4,STAT3,DCAF7,CCT8,GNAZ,CCT2,GNB1,FBXO6,GBA1,FBXW2,RGS7,RGS11,LONP2,TUBA1B,GNG13,TUBA1A,RGS6,GNB4,TUBB6,RGS9,NOP56,TUBB4A,CCNE2,FBXO4,GNB5,ARFGEF2,CSNK2A1,AP3M1,GNAT1,GNGT1,FKBP9,FBXL3,GNB3,GNG12,CCT7,GNAT3,GNG2,TUBAL3,GNG8,PDCL,TUBB2B,PFDN5,FBXW7
R-HSA-399955	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	0.972162577148874	-0.0282322280669378	15	11	0.00121762231569626	9034	10285	23396,5362,2534,27289,2242,6237,91584,10371,5879,5361,8829	PIP5K1C,PLXNA2,FYN,RND1,FES,RRAS,PLXNA4,SEMA3A,RAC1,PLXNA1,NRP1
R-HSA-2187335	The retinoid cycle in cones (daylight vision)	0.972973788368082	-0.027398136143492	6	4	0.000442771751162276	9034	10285	9249,611,5949,6017	DHRS3,OPN1SW,RBP3,RLBP1
R-HSA-444257	RSK activation	0.972973788368082	-0.027398136143492	6	4	0.000442771751162276	9034	10285	5594,6195,6196,5170	MAPK1,RPS6KA1,RPS6KA2,PDPK1
R-HSA-73762	RNA Polymerase I Transcription Initiation	0.973458955520381	-0.0268996168251439	48	38	0.00420633163604162	9034	10285	1022,2967,2965,57459,2071,1108,404672,1107,5440,9219,51082,7343,2968,10919,2074,54700,54815,9533,57504,3065,64425,4331,84172,2068,9015,7270,10849,79101,5441,5928,221830,5434,3066,902,53615,9014,25885,8850	CDK7,GTF2H3,GTF2H1,GATAD2B,ERCC3,CHD4,GTF2H5,CHD3,POLR2K,MTA2,POLR1D,UBTF,GTF2H4,EHMT2,ERCC6,RRN3,GATAD2A,POLR1C,MTA3,HDAC1,POLR1E,MNAT1,POLR1B,ERCC2,TAF1A,TTF1,POLR1G,TAF1D,POLR2L,RBBP4,POLR1F,POLR2E,HDAC2,CCNH,MBD3,TAF1B,POLR1A,KAT2B
R-HSA-442380	Zinc influx into cells by the SLC39 gene family	0.975007988703162	-0.0253096144761518	10	7	0.000774850564533983	9034	10285	29985,283375,25800,57181,29986,23516,64116	SLC39A3,SLC39A5,SLC39A6,SLC39A10,SLC39A2,SLC39A14,SLC39A8
R-HSA-390450	Folding of actin by CCT/TriC	0.975007988703162	-0.0253096144761518	10	7	0.000774850564533983	9034	10285	22948,10576,10693,60,10694,10575,10574	CCT5,CCT2,CCT6B,ACTB,CCT8,CCT4,CCT7
R-HSA-201688	WNT mediated activation of DVL	0.975007988703162	-0.0253096144761518	10	7	0.000774850564533983	9034	10285	1855,1856,1454,1857,1457,1459,8395	DVL1,DVL2,CSNK1E,DVL3,CSNK2A1,CSNK2A2,PIP5K1B
R-HSA-2046105	Linoleic acid (LA) metabolism	0.975007988703162	-0.0253096144761518	10	7	0.000774850564533983	9034	10285	9415,64834,83401,3992,60481,2180,54898	FADS2,ELOVL1,ELOVL3,FADS1,ELOVL5,ACSL1,ELOVL2
R-HSA-168273	Influenza Viral RNA Transcription and Replication	0.97597465343682	-0.0243186627455903	137	113	0.0125083019703343	9034	10285	6152,6137,6135,4927,6231,6224,7311,6136,5439,23521,81929,6164,6210,129401,7175,6122,5441,6189,6208,6229,5611,6217,6194,4736,348995,6130,79902,6201,6233,6169,6142,5434,6228,6161,2926,6188,6209,79023,55706,9688,51065,6125,6234,6168,6181,6146,5433,51121,11224,6156,100101267,23165,6204,6223,116832,5431,6157,2963,6155,53371,3843,9349,6159,9883,8021,6235,9045,6124,8086,5432,6144,9631,200916,6138,5440,4928,6129,23636,10762,6206,6154,6205,6230,57122,6207,2962,55746,6133,3921,6165,6167,6202,6128,3320,5430,11097,25873,6166,6227,9818,5903,6176,23279,23511,140801,6123,6175,6139,23225,9972,6143,6160,6232	RPL24,RPL13,RPL11,NUP88,RPS26,RPS20,UBA52,RPL12,POLR2J,RPL13A,SEH1L,RPL34,RPS15A,NUP35,TPR,RPL3,POLR2L,RPS3A,RPS14,RPS24,DNAJC3,RPS16,RPS6,RPL10A,NUP43,RPL7A,NUP85,RPS7,RPS27A,RPL38,RPL18A,POLR2E,RPS23,RPL32,GRSF1,RPS3,RPS15,NUP37,NDC1,NUP93,RPS27L,RPL5,RPS28,RPL37A,RPLP2,RPL22,POLR2D,RPL26L1,RPL35,RPL30,POM121C,NUP205,RPS10,RPS19,RPL39L,POLR2B,RPL27A,GTF2F2,RPL27,NUP54,IPO5,RPL23,RPL29,POM121,NUP214,RPS29,RPL14,RPL4,AAAS,POLR2C,RPL21,NUP155,RPL22L1,RPL15,POLR2K,NUP98,RPL7,NUP62,NUP50,RPS12,RPL26,RPS11,RPS25,NUP107,RPS13,GTF2F1,NUP133,RPL9,RPSA,RPL35A,RPL37,RPS8,RPL6,HSP90AA1,POLR2A,NUP42,RPL36,RPL36AL,RPS21,NUP58,RANBP2,RPLP1,NUP160,NUP188,RPL10L,RPL3L,RPLP0,RPL17,NUP210,NUP153,RPL19,RPL31,RPS27
R-HSA-168254	Influenza Infection	0.976532302736598	-0.0237474490931344	157	130	0.014390081912774	9034	10285	7311,6224,6231,4927,6135,6137,6152,9636,81929,23521,5439,6136,3838,811,7175,129401,6210,6164,6208,6189,6122,5441,348995,4736,6194,6217,5611,6229,6169,6233,6201,79902,6130,5434,6142,6228,79023,6209,6188,2926,1211,6161,6234,6125,51065,9688,7040,55706,5433,6146,6181,6168,116832,6223,6204,100101267,23165,6156,11224,51121,5431,53371,6155,2963,6157,9349,3843,10898,3839,7514,1213,6159,6124,3837,6235,9045,8021,9883,9631,821,5610,5432,6144,8086,4928,5440,200916,3836,6138,10762,23636,6129,6154,6206,8106,2962,55746,6133,6207,57122,6205,6230,6167,6165,3921,6128,3320,6202,6166,25873,11097,5430,5901,9818,6227,6176,5903,6123,140801,23511,23279,402569,6160,6143,9972,23225,3840,6139,6175,6232	UBA52,RPS20,RPS26,NUP88,RPL11,RPL13,RPL24,ISG15,SEH1L,RPL13A,POLR2J,RPL12,KPNA2,CALR,TPR,NUP35,RPS15A,RPL34,RPS14,RPS3A,RPL3,POLR2L,NUP43,RPL10A,RPS6,RPS16,DNAJC3,RPS24,RPL38,RPS27A,RPS7,NUP85,RPL7A,POLR2E,RPL18A,RPS23,NUP37,RPS15,RPS3,GRSF1,CLTA,RPL32,RPS28,RPL5,RPS27L,NUP93,TGFB1,NDC1,POLR2D,RPL22,RPLP2,RPL37A,RPL39L,RPS19,RPS10,POM121C,NUP205,RPL30,RPL35,RPL26L1,POLR2B,NUP54,RPL27,GTF2F2,RPL27A,RPL23,IPO5,CPSF4,KPNA3,XPO1,CLTC,RPL29,RPL4,KPNB1,RPS29,RPL14,NUP214,POM121,NUP155,CANX,EIF2AK2,POLR2C,RPL21,AAAS,NUP98,POLR2K,RPL22L1,KPNA1,RPL15,NUP50,NUP62,RPL7,RPL26,RPS12,PABPN1,GTF2F1,NUP133,RPL9,RPS13,NUP107,RPS11,RPS25,RPL37,RPL35A,RPSA,RPL6,HSP90AA1,RPS8,RPL36AL,RPL36,NUP42,POLR2A,RAN,NUP58,RPS21,RPLP1,RANBP2,RPL3L,RPL10L,NUP188,NUP160,KPNA7,RPL31,RPL19,NUP153,NUP210,KPNA4,RPL17,RPLP0,RPS27
R-HSA-167161	HIV Transcription Initiation	0.977108612883784	-0.0231574633293276	47	37	0.00409563869825105	9034	10285	6879,2958,2068,83860,5441,6884,138474,5431,4331,6873,2963,2962,2960,6881,5434,902,2957,100302168,2071,2961,6880,404672,6882,1022,2967,6883,2965,6874,2959,6877,6875,5432,2968,5430,5439,5440,5433	TAF7,GTF2A2,ERCC2,TAF3,POLR2L,TAF13,TAF1L,POLR2B,MNAT1,TAF2,GTF2F2,GTF2F1,GTF2E1,TAF10,POLR2E,CCNH,GTF2A1,MIR1257,ERCC3,GTF2E2,TAF9,GTF2H5,TAF11,CDK7,GTF2H3,TAF12,GTF2H1,TAF4,GTF2B,TAF5,TAF4B,POLR2C,GTF2H4,POLR2A,POLR2J,POLR2K,POLR2D
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	0.977108612883784	-0.0231574633293276	47	37	0.00409563869825105	9034	10285	6882,404672,6880,2961,2071,2965,6883,1022,2967,2959,6874,6875,6877,5430,5439,2968,5432,5433,5440,83860,2958,2068,6879,5441,4331,138474,5431,6884,6873,2963,902,5434,2960,6881,2962,100302168,2957	TAF11,GTF2H5,TAF9,GTF2E2,ERCC3,GTF2H1,TAF12,CDK7,GTF2H3,GTF2B,TAF4,TAF4B,TAF5,POLR2A,POLR2J,GTF2H4,POLR2C,POLR2D,POLR2K,TAF3,GTF2A2,ERCC2,TAF7,POLR2L,MNAT1,TAF1L,POLR2B,TAF13,TAF2,GTF2F2,CCNH,POLR2E,GTF2E1,TAF10,GTF2F1,MIR1257,GTF2A1
R-HSA-73776	RNA Polymerase II Promoter Escape	0.977108612883784	-0.0231574633293276	47	37	0.00409563869825105	9034	10285	2963,2962,6881,2960,5434,902,2957,100302168,6879,2068,2958,83860,5441,6884,5431,138474,4331,6873,6877,6875,5432,2968,5439,5430,5440,5433,2071,6880,2961,404672,6882,2967,1022,6883,2965,6874,2959	GTF2F2,GTF2F1,TAF10,GTF2E1,POLR2E,CCNH,GTF2A1,MIR1257,TAF7,ERCC2,GTF2A2,TAF3,POLR2L,TAF13,POLR2B,TAF1L,MNAT1,TAF2,TAF5,TAF4B,POLR2C,GTF2H4,POLR2J,POLR2A,POLR2K,POLR2D,ERCC3,TAF9,GTF2E2,GTF2H5,TAF11,GTF2H3,CDK7,TAF12,GTF2H1,TAF4,GTF2B
R-HSA-75953	RNA Polymerase II Transcription Initiation	0.977108612883784	-0.0231574633293276	47	37	0.00409563869825105	9034	10285	5441,2958,2068,83860,6879,6873,138474,5431,4331,6884,2963,2957,100302168,5434,902,2962,6881,2960,2961,404672,6880,6882,2071,6874,2959,2965,2967,1022,6883,5432,2968,5439,5430,6875,6877,5433,5440	POLR2L,GTF2A2,ERCC2,TAF3,TAF7,TAF2,TAF1L,POLR2B,MNAT1,TAF13,GTF2F2,GTF2A1,MIR1257,POLR2E,CCNH,GTF2F1,TAF10,GTF2E1,GTF2E2,GTF2H5,TAF9,TAF11,ERCC3,TAF4,GTF2B,GTF2H1,GTF2H3,CDK7,TAF12,POLR2C,GTF2H4,POLR2J,POLR2A,TAF4B,TAF5,POLR2D,POLR2K
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	0.977108612883784	-0.0231574633293276	47	37	0.00409563869825105	9034	10285	2963,902,5434,6881,2960,2962,100302168,2957,83860,2958,2068,6879,5441,5431,4331,138474,6884,6873,6875,6877,5439,5430,5432,2968,5433,5440,6882,404672,2961,6880,2071,2965,6883,2967,1022,2959,6874	GTF2F2,CCNH,POLR2E,TAF10,GTF2E1,GTF2F1,MIR1257,GTF2A1,TAF3,GTF2A2,ERCC2,TAF7,POLR2L,POLR2B,MNAT1,TAF1L,TAF13,TAF2,TAF4B,TAF5,POLR2J,POLR2A,POLR2C,GTF2H4,POLR2D,POLR2K,TAF11,GTF2H5,GTF2E2,TAF9,ERCC3,GTF2H1,TAF12,GTF2H3,CDK7,GTF2B,TAF4
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	0.977108612883784	-0.0231574633293276	47	37	0.00409563869825105	9034	10285	6884,5431,4331,138474,6873,6879,2958,2068,83860,5441,2962,6881,2960,5434,902,2957,100302168,2963,1022,2967,6883,2965,6874,2959,2071,2961,6880,404672,6882,5440,5433,6877,6875,2968,5432,5430,5439	TAF13,POLR2B,MNAT1,TAF1L,TAF2,TAF7,GTF2A2,ERCC2,TAF3,POLR2L,GTF2F1,TAF10,GTF2E1,POLR2E,CCNH,GTF2A1,MIR1257,GTF2F2,CDK7,GTF2H3,TAF12,GTF2H1,TAF4,GTF2B,ERCC3,GTF2E2,TAF9,GTF2H5,TAF11,POLR2K,POLR2D,TAF5,TAF4B,GTF2H4,POLR2C,POLR2A,POLR2J
R-HSA-3214847	HATs acetylate histones	0.977370631240033	-0.0228893424387057	143	118	0.0130617666592871	9034	10285	23522,8359,57634,8969,10445,26610,8344,100302237,10474,54556,10933,55578,8354,284058,1387,128312,8362,6944,23774,8349,1386,8295,10499,8341,8370,8367,8365,126961,3018,1810,10856,51147,10629,6871,8353,10524,8348,121504,8366,10902,11091,79960,6883,8334,117143,7994,3013,8968,653604,6314,8607,6881,55167,56943,8358,7862,92815,8343,8339,8360,55689,23326,440689,23587,55250,8335,8352,8648,27097,55257,8518,723790,8364,79595,55929,8089,23338,8464,80314,3012,55140,112869,26009,84148,221613,86,27154,9913,51562,8350,57325,8361,64769,8345,9575,8520,8347,339287,54934,2033,6880,51230,11143,56970,8368,3017,8346,8850,54859,55683,8355,8970,8357,8332,8363,5077,8340,60	KAT6B,H4C1,EP400,H2AC11,MCRS1,ELP4,H2BC6,MIR1281,TADA3,ING3,MORF4L1,SUPT20H,H3C11,KANSL1,CREBBP,H2BC26,H4C12,VPS72,BRD1,H2BC21,ATF2,TRRAP,NCOA2,H2BC15,H4C14,H4C5,H4C8,H3C14,H2BC3,DR1,RUVBL2,ING4,TAF6L,TADA2A,H3C6,KAT5,H2BC17,H4C16,H4C2,BRD8,WDR5,JADE1,TAF12,H2AC6,TADA1,KAT6A,H2AC7,H3C7,H3C13,ATXN7,RUVBL1,TAF10,MSL2,ENY2,H3C2,BRPF1,H2AC25,H2BC7,H2BC8,H4C4,YEATS2,USP22,H2BC18,ELP5,ELP2,H2AC4,H3C3,NCOA1,TAF5L,MRGBP,ELP1,H2AC19,H4C3,SAP130,DMAP1,YEATS4,JADE2,SUPT3H,EPC1,H2AC8,ELP3,SGF29,ZZZ3,KAT8,H2AC1,ACTL6A,BRPF3,SUPT7L,MBIP,H3C1,KAT14,H4C6,MEAF6,H2BC9,CLOCK,HAT1,H2BC4,MSL1,KANSL2,EP300,TAF9,PHF20,KAT7,ATXN7L3,H4C13,H2BC5,H2BC10,KAT2B,ELP6,KANSL3,H3C8,H2BC11,H3C10,H2AC16,H4C11,PAX3,H2BC13,ACTB
R-HSA-167172	Transcription of the HIV genome	0.978712847526093	-0.0215169915024752	77	62	0.00686296214301528	9034	10285	6749,904,5441,7469,8812,6873,6921,6827,902,5434,6881,100302242,2962,8731,6880,404672,100126332,6883,1022,2959,7936,6875,51224,6877,162699,5439,5432,905,5440,6923,83860,2068,2958,6879,5431,138474,4331,6884,22916,2963,4686,2960,8732,100302168,2957,6924,8178,6829,9150,6882,2961,2071,2965,2967,6874,11198,100506888,6917,5430,2968,5433,51497	SSRP1,CCNT1,POLR2L,NELFA,CCNK,TAF2,ELOC,SUPT4H1,CCNH,POLR2E,TAF10,MIR1236,GTF2F1,RNMT,TAF9,GTF2H5,MIR943,TAF12,CDK7,GTF2B,NELFE,TAF4B,ELOA2,TAF5,ELOA3P,POLR2J,POLR2C,CCNT2,POLR2K,ELOB,TAF3,ERCC2,GTF2A2,TAF7,POLR2B,TAF1L,MNAT1,TAF13,NCBP2,GTF2F2,NCBP1,GTF2E1,RNGTT,MIR1257,GTF2A1,ELOA,ELL,SUPT5H,CTDP1,TAF11,GTF2E2,ERCC3,GTF2H1,GTF2H3,TAF4,SUPT16H,ELOA3DP,TCEA1,POLR2A,GTF2H4,POLR2D,NELFCD
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	0.979967946643409	-0.0202354153591467	115	94	0.0104051361523135	9034	10285	6143,6139,6175,6160,6232,6176,6123,140801,6166,6185,6728,25873,6227,3921,6167,6734,6165,6202,6128,1650,60559,10952,6207,6729,6205,6230,6133,6129,6206,6154,90701,6144,6731,23480,6138,200916,6159,23478,9045,6235,6124,6155,6157,29927,9349,6156,11224,51121,116832,6223,6204,6125,51065,6747,6234,6745,6181,6168,6726,23471,6146,6746,6228,6727,6209,6188,6161,58477,55176,6130,6169,6233,6201,9789,6142,6122,6208,6189,6217,6730,6229,4736,6194,23521,6136,6210,6164,6135,6137,6152,6231,6224,7311,6184	RPL19,RPL17,RPLP0,RPL31,RPS27,RPLP1,RPL3L,RPL10L,RPL36AL,RPN2,SRP19,RPL36,RPS21,RPSA,RPL37,SRPRA,RPL35A,RPS8,RPL6,DDOST,SPCS3,SEC61B,RPS13,SRP54,RPS11,RPS25,RPL9,RPL7,RPS12,RPL26,SEC11C,RPL21,SRP72,SEC61G,RPL15,RPL22L1,RPL29,SEC11A,RPL14,RPS29,RPL4,RPL27,RPL27A,SEC61A1,RPL23,RPL30,RPL35,RPL26L1,RPL39L,RPS19,RPS10,RPL5,RPS27L,SSR3,RPS28,SSR1,RPLP2,RPL37A,SRP9,TRAM1,RPL22,SSR2,RPS23,SRP14,RPS15,RPS3,RPL32,SRPRB,SEC61A2,RPL7A,RPL38,RPS27A,RPS7,SPCS2,RPL18A,RPL3,RPS14,RPS3A,RPS16,SRP68,RPS24,RPL10A,RPS6,RPL13A,RPL12,RPS15A,RPL34,RPL11,RPL13,RPL24,RPS26,RPS20,UBA52,RPN1
R-HSA-3214842	HDMs demethylate histones	0.980044531486354	-0.0201572680577001	52	41	0.00453841044941333	9034	10285	8368,8364,84159,23028,23135,51780,121504,84864,8366,23030,79831,8361,8353,55818,5253,22992,84678,55693,8370,8352,8350,8359,23210,8367,80853,8365,126961,8363,8355,8357,8362,8360,221656,10765,8968,653604,8354,8358,5927,9682,23081	H4C13,H4C3,ARID5B,KDM1A,KDM6B,KDM3B,H4C16,RIOX2,H4C2,KDM4B,KDM8,H4C6,H3C6,KDM3A,PHF2,KDM2A,KDM2B,KDM4D,H4C14,H3C3,H3C1,H4C1,JMJD6,H4C5,KDM7A,H4C8,H3C14,H4C11,H3C8,H3C10,H4C12,H4C4,KDM1B,KDM5B,H3C7,H3C13,H3C11,H3C2,KDM5A,KDM4A,KDM4C
R-HSA-167287	HIV elongation arrest and recovery	0.981122360378207	-0.0190580969419309	40	31	0.00343148107150764	9034	10285	7936,11198,9150,6829,100126332,5440,905,5433,6923,51497,100506888,6917,51224,5430,5439,5432,162699,5431,6921,6749,8812,7469,904,5441,100302242,2962,5434,6924,8178,6827,2963	NELFE,SUPT16H,CTDP1,SUPT5H,MIR943,POLR2K,CCNT2,POLR2D,ELOB,NELFCD,ELOA3DP,TCEA1,ELOA2,POLR2A,POLR2J,POLR2C,ELOA3P,POLR2B,ELOC,SSRP1,CCNK,NELFA,CCNT1,POLR2L,MIR1236,GTF2F1,POLR2E,ELOA,ELL,SUPT4H1,GTF2F2
R-HSA-167290	Pausing and recovery of HIV elongation	0.981122360378207	-0.0190580969419309	40	31	0.00343148107150764	9034	10285	7469,8812,904,5441,6749,6921,5431,2963,6827,6924,8178,100302242,2962,5434,100126332,9150,6829,7936,11198,5439,5430,5432,162699,100506888,6917,51224,6923,51497,5440,905,5433	NELFA,CCNK,CCNT1,POLR2L,SSRP1,ELOC,POLR2B,GTF2F2,SUPT4H1,ELOA,ELL,MIR1236,GTF2F1,POLR2E,MIR943,CTDP1,SUPT5H,NELFE,SUPT16H,POLR2J,POLR2A,POLR2C,ELOA3P,ELOA3DP,TCEA1,ELOA2,ELOB,NELFCD,POLR2K,CCNT2,POLR2D
R-HSA-157579	Telomere Maintenance	0.98164025203742	-0.0185303798680926	82	66	0.00730573389417755	9034	10285	8367,3018,8365,8341,8370,94239,8345,55651,8347,5558,10856,8361,8366,121504,5983,55135,5557,8348,8334,1763,54107,8346,7015,3015,8368,3017,3013,5981,5111,5427,7013,6118,5985,8607,8360,65057,8343,8970,6117,23649,8339,8340,56655,8363,6119,8335,8359,7014,8290,723790,8344,26277,57804,8364,5982,2237,3978,55766,10714,25913,3012,5984,8362,128312,5424,8349	H4C5,H2BC3,H4C8,H2BC15,H4C14,H2AZ2,H2BC9,NHP2,H2BC4,PRIM2,RUVBL2,H4C6,H4C2,H4C16,RFC3,WRAP53,PRIM1,H2BC17,H2AC6,DNA2,POLE3,H2BC10,TERT,H2AZ1,H4C13,H2BC5,H2AC7,RFC1,PCNA,POLE2,TERF1,RPA2,RFC5,RUVBL1,H4C4,ACD,H2BC7,H2BC11,RPA1,POLA2,H2BC8,H2BC13,POLE4,H4C11,RPA3,H2AC4,H4C1,TERF2,H3-4,H2AC19,H2BC6,TINF2,POLD4,H4C3,RFC2,FEN1,LIG1,H2AJ,POLD3,POT1,H2AC8,RFC4,H4C12,H2BC26,POLD1,H2BC21
R-HSA-674695	RNA Polymerase II Pre-transcription Events	0.982268449030901	-0.0178906383011202	88	71	0.0078591985831304	9034	10285	2968,5430,6917,100506888,51497,5433,27125,2071,54623,2961,6882,4298,9150,6829,9646,55677,11198,6874,2967,2965,2963,8178,6924,2957,100302168,23168,2960,4686,4300,6879,2068,2958,83860,22916,6884,5431,138474,4331,5432,5439,162699,6877,79577,85403,6875,51224,6923,5440,905,100126332,6880,404672,7936,55840,2959,1022,6883,6827,2962,6881,100302242,5434,902,7469,8812,5441,904,6749,123169,6921,6873	GTF2H4,POLR2A,TCEA1,ELOA3DP,NELFCD,POLR2D,AFF4,ERCC3,PAF1,GTF2E2,TAF11,MLLT1,CTDP1,SUPT5H,CTR9,IWS1,SUPT16H,TAF4,GTF2H3,GTF2H1,GTF2F2,ELL,ELOA,GTF2A1,MIR1257,RTF1,GTF2E1,NCBP1,MLLT3,TAF7,ERCC2,GTF2A2,TAF3,NCBP2,TAF13,POLR2B,TAF1L,MNAT1,POLR2C,POLR2J,ELOA3P,TAF5,CDC73,EAF1,TAF4B,ELOA2,ELOB,POLR2K,CCNT2,MIR943,TAF9,GTF2H5,NELFE,EAF2,GTF2B,CDK7,TAF12,SUPT4H1,GTF2F1,TAF10,MIR1236,POLR2E,CCNH,NELFA,CCNK,POLR2L,CCNT1,SSRP1,LEO1,ELOC,TAF2
R-HSA-171306	Packaging Of Telomere Ends	0.982805506582418	-0.0173440353975962	51	40	0.00442771751162276	9034	10285	8361,8290,8345,8347,94239,8370,8335,8341,7014,8359,8367,8365,3018,8368,3015,8364,3017,8334,26277,8346,8344,8348,121504,8366,723790,3012,25913,55766,7013,3013,8363,8349,8340,8343,8970,8339,128312,8362,8360,65057	H4C6,H3-4,H2BC9,H2BC4,H2AZ2,H4C14,H2AC4,H2BC15,TERF2,H4C1,H4C5,H4C8,H2BC3,H4C13,H2AZ1,H4C3,H2BC5,H2AC6,TINF2,H2BC10,H2BC6,H2BC17,H4C16,H4C2,H2AC19,H2AC8,POT1,H2AJ,TERF1,H2AC7,H4C11,H2BC21,H2BC13,H2BC7,H2BC11,H2BC8,H2BC26,H4C12,H4C4,ACD
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	0.983221899092674	-0.0169204476945153	75	60	0.00664157626743414	9034	10285	80145,6430,10569,79023,11097,9688,55706,22794,6429,26097,9818,100101267,23165,51362,5903,8683,29107,22916,23279,23511,9775,23225,9972,53371,6431,9984,9295,4686,4927,8563,6432,8021,9883,10250,8086,9877,10189,9631,81929,10482,84248,84271,4116,10212,7307,7175,4928,129401,23636,10762,11338,348995,55110,79902,84324,6428,84321,57122,6426,55746	THOC7,SRSF5,SLU7,NUP37,NUP42,NUP93,NDC1,CASC3,SRSF4,CHTOP,NUP58,POM121C,NUP205,CDC40,RANBP2,SRSF9,NXT1,NCBP2,NUP160,NUP188,EIF4A3,NUP210,NUP153,NUP54,SRSF6,THOC1,SRSF11,NCBP1,NUP88,THOC5,SRSF7,NUP214,POM121,SRRM1,AAAS,ZC3H11A,ALYREF,NUP155,SEH1L,NXF1,FYTTD1,POLDIP3,MAGOH,DDX39A,U2AF1,TPR,NUP98,NUP35,NUP62,NUP50,U2AF2,NUP43,MAGOHB,NUP85,SARNP,SRSF3,THOC3,NUP107,SRSF1,NUP133
R-HSA-162582	Signal Transduction	0.983431464292676	-0.0167073290995494	2547	2207	0.244299313703786	9034	10285	488,1869,347148,6866,221472,2918,5694,2773,8682,2862,9718,341568,9742,5467,138803,25805,4486,5880,10276,10888,29967,11108,28956,138805,5321,344892,9365,80199,94235,1019,3577,644150,6016,7046,64577,391192,1081,6755,195814,27202,5062,7124,100271715,2735,3360,1447,2919,2208,9626,1488,5290,138882,389,5582,119692,26493,504189,157506,10603,9241,3570,2118,55937,4771,8111,127,256933,10787,10109,2889,219453,5154,10048,338398,6357,7415,5568,121214,115557,282775,5708,135941,701,346517,2790,84152,4314,57449,653361,3479,2797,10125,611,1258,26108,535,4985,6232,343406,2252,5604,10193,6256,283092,1259,51377,7375,57551,5141,1060,3827,85415,3071,6753,2847,345,983,10451,10726,219870,3716,124056,26533,2905,9397,283162,26696,595,2922,81470,144165,4991,4914,8340,8527,5216,2266,3918,23432,1128,1785,81617,4090,9886,5179,10670,8388,390260,1030,5713,7484,53831,8347,8556,6385,5596,341799,58504,10252,255725,6423,219858,805,140,5539,10022,50940,10886,57121,3012,752,100288637,8743,8394,135924,8837,3560,23220,5979,50617,81442,7050,64837,1131,219958,29904,1432,26686,10642,7057,5829,259296,60436,185,7091,9793,8822,4157,51764,91653,84870,8786,55288,23370,5906,221391,1129,219986,3567,392376,57122,23566,1234,81127,5020,7533,26574,55764,84144,5921,8870,9965,5032,6383,3337,5715,1003,1286,7316,6346,5578,126,5996,8877,121504,5368,2342,10810,5138,2903,4690,5196,1839,121130,57007,1387,5579,7476,22916,2832,5139,6464,3061,23118,8362,4035,138799,10399,57016,58480,5430,4836,643,29933,7409,8038,6712,54886,4852,6000,127124,6288,100302237,8383,26052,2768,8526,5718,5590,4920,659,5217,1609,6774,10552,117,7422,27199,9611,6453,84951,55733,84078,153,83597,27115,6870,10268,286365,8644,284654,81061,64388,114822,10657,81929,64106,445328,81392,9736,8346,1123,2260,431704,5597,3913,23122,5575,6932,1374,64407,5691,128272,7855,10093,7027,182,56998,2475,8651,221035,5900,11221,1457,25759,207,3674,8787,5781,441932,1608,5241,119774,5719,2769,25909,5173,4803,5533,9290,346528,259289,843,8607,390429,26740,245972,55746,3915,5573,55160,26166,1212,406975,9568,9861,10235,7072,699,3352,390327,83439,143502,119772,2064,2908,4638,50848,390265,117145,1844,390261,7979,5997,79718,3796,54763,9110,5144,552,9047,6455,4893,26246,1592,90226,3643,259285,1875,390197,6696,5500,650,344,80346,4734,84643,9306,2692,5499,10018,5151,7477,1902,390084,2826,157,5933,81029,9982,2909,10312,2242,50649,2782,136,113,26469,673,54492,5565,995,57591,9828,6487,6194,8357,4041,390067,50833,3625,4988,390442,100302213,57406,3952,64108,128368,9978,8326,8350,3984,2308,2913,7089,2778,10266,3315,116,5737,133,10468,58191,2309,1325,4994,26230,5296,219875,151648,163404,10663,3576,5163,2034,6017,7200,219873,7088,2779,4140,219952,390155,338,57514,7040,6010,80835,53630,6725,2885,11250,7481,2674,219957,5516,6372,79885,1816,4792,50846,6461,3908,6654,442194,10435,1392,79823,2915,11343,219954,9672,9138,26248,59350,8065,7297,89846,5563,219436,6610,119678,846,5046,2796,125958,113878,5795,55970,5777,3814,57728,7321,156,3002,9938,5924,3710,84894,5916,5335,3909,84658,283365,26658,121275,108,3717,26020,5685,23645,525,390064,5770,390437,4543,196883,5707,116985,5567,114793,26188,51699,8355,5441,6865,254783,3627,3265,25937,5142,408,403278,50834,718,8440,5048,4485,25780,2251,2798,9475,9184,3831,3354,23538,23288,7074,256148,5700,3178,390058,192670,79980,10413,1540,4974,8660,1759,2736,29851,4145,401667,155066,2784,219968,2244,2321,129521,64096,8202,79659,128371,143282,11113,23779,2848,2339,2887,7222,80326,4772,5733,8841,390326,147179,6934,5581,2917,115727,285601,5519,9826,1147,7424,79544,6772,4615,51741,8353,6863,64411,5744,4986,51109,403244,338755,1017,3579,441911,93663,324,2776,942,5305,5330,355,8854,54429,6364,8817,5687,55615,5894,2861,3020,5518,1487,10316,8549,1111,127385,10142,2829,6789,3688,4684,143872,657,6343,6711,6794,6249,2906,885,134864,613,441669,132884,10718,9034,9113,5367,8361,5137,27121,8878,150,3798,3062,5439,4902,4343,2831,5028,23286,3640,2979,8555,389337,5577,6009,5595,10616,1394,5029,53829,7976,10170,4747,3799,51107,339745,220134,528,100422894,2978,391189,10213,1455,79784,7473,55004,3339,5905,343169,219956,51231,6788,84441,2853,5031,5922,729966,10094,286205,8630,653604,9846,5593,4923,1285,6608,3709,3569,54820,56477,8622,7433,5970,347169,7059,26539,2121,151306,84539,83464,4159,4192,55789,10126,1132,5995,7984,6457,10817,998,3910,23173,120892,23462,5724,2263,8312,10524,23543,10197,8348,8387,4609,10911,1956,80004,51592,100302274,150681,4036,335,440193,6374,8349,5903,261734,4099,7475,5170,3568,10959,3708,1606,4992,2921,100616459,23380,4158,29984,3481,11127,81696,7058,5406,5530,4637,2781,3516,403277,2241,2324,5058,23236,51384,8525,162998,51083,301,51466,1901,8608,2859,5664,2691,9735,8345,5576,6387,56923,7479,57405,9048,10272,5136,57154,5998,26534,390075,7478,391196,394,346562,388531,5999,55843,348,8992,23596,2254,5433,9181,3375,3351,79295,102,1211,6003,817,50837,94134,26735,84335,836,685,65055,392392,54903,7905,4093,8343,5717,2767,56656,36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183,27123,26160,201176,6421,132112,489,4993,152559,1175,842,1452,1499,284433,9580,351,10850,26648,5897,5684,8976,5164,71,2033,1535,1500,2492,400581,5699,390154,26575,171177,152,5592,4922,388,7456,2914,4193,1975,5698,1026,3065,6655,90423,26529,26999,8658,7432,219874,1133,1269,867,284217,221955,338557,9462,5125,26333,343637,130075,5747,22943,8313,134,51052,59340,2262,4763,57113,2247,10768,3728,3185,2787,441670,1907,126541,27152,8490,5525,4995,9912,1173,7529,442191,1241,202559,55701,4629,2852,5159,10457,2675,55845,160851,7349,58513,391,7472,112,50964,55233,7531,2780,5923,8366,57105,3624,6195,8936,8315,390063,4628,5158,27327,5564,2591,50508,5704,10156,5959,3350,83737,23526,553,4318,3357,187,221002,9187,9411,9148,2550,51564,1742,3985,10589,1282,390445,117289,5528,442186,56670,3911,81285,5605,3562,8970,138804,283093,3725,55914,64321,29924,79019,219473,29127,53834,607,5896,343578,6366,55553,1437,4023,6497,3017,3082,79837,6199,8724,124,27006,1855,2932,23545,1027,526,941,3480,10971,1871,5155,2920,83478,7414,24,6198,9824,83888,92,26084,4092,81399,54778,2870,5746,81697,155,5529,7450,7525,5693,2774,1020,79023,11197,283189,797,10901,1906,4659,26496,285659,138881,7248,330,10395,6754,6242,115,134083,121364,55055,2246,9934,2786,10319,8360,6850,2837,23198,8439,6659,6692,4242,5432,8367,119695,5603,6710,219479,594857,1382,5571,6002,2696,89953,6400,5879,8503,3792,5695,1978,54331,109,2520,55081,10273,160,128674,1495,2532,7249,5037,10563,10203,63916,51176,26538,5245,11059,64333,10254,5153,30851,138802,26524,3356,5929,3320,2668,6885,9249,9794,2147,8649,10161,57381,79658,81930,80310,9890,4086,6376,2911,64926,3362,26664,10287,1604,2017,94239,79577,658,5580,222236,1910,30817,3572,10818,340980,25776,6295,7483,5714,3895,8797,135,85397,9844,8322,6778,3021,796,158131,9559,23332,3932,1235,56603,9287,4295,2867,154810,8811,26707,9212,5331,81050,338442,23385,5726,399473,8567,25936,523,6846,5701,2962,10956,5948,1849,2250,7253,64748,8395,2641,1062,4846,4205,5440,9958,3972,80152,8370,10499,80834,1297,2069,83933,7015,390190,9414,9491,64750,390038,23620,4686,4915,90268,5660,9564,50700,1880,81341,23072,2792,2904,1812,1233,142678,1848,7534,120793,353299,119679,23002,5949,466,6915,5148,5494,10454,26693,8454,9099,9261,399,10403,7323,6352	ATP2A2,E2F1,QRFP,TAC3,FGD2,GRM8,PSMB6,GNAI3,PEA15,MLNR,ECE2,OR8S1,IFT140,PPARD,OR13C3,BAMBI,MST1R,RAC2,NET1,GPR83,LRP12,PRDM4,LAMTOR2,OR13F1,PLA2G4A,RTP2,KL,FUZ,GNG8,CDK4,CXCR1,WIPF3,RIT1,TGFBR1,ALDH8A1,OR2L3,CGA,SSTR5,SDR16C5,C5AR2,PAK2,TNF,ARHGEF33,GLI1,HTR4,CSN2,CXCL1,FCER2,GUCA1C,CTBP2,PIK3CA,OR1N2,RHOC,PRKCG,OR51S1,OR8B8,OR8U8,RDH10,SH2B2,NOG,IL6R,ETV4,APOM,NF2,GPR68,ADH4,NPB,NCKAP1,ARPC2,RAPGEF1,OR8K5,PDGFA,RANBP9,TAS2R60,CCL13,VCP,PRKACG,SDR9C7,ARHGEF25,OR5J2,PSMD2,OR2A14,BUB1B,OR6V1,GNG10,PPP1R1B,MMP3,PLEKHG5,NCF1,IGF1,GNRH2,RASGRP1,OPN1SW,CNGB1,PYGO1,ATP6V0A1,OPRD1,RPS27,OR10R2,FGF7,MAP2K1,RNF41,RXRA,OR4C13,CNGA1,UCHL5,USP4,TAOK1,PDE4A,CENPC,KNG1,RHPN2,NCKAP1L,SSTR3,MCHR1,APOC3,CDK1,VAV3,NUDC,OR10G9,JAK1,NOXO1,OR10G3,GRIN2C,NMT2,OR8B4,OR2T1,CCND1,GRP,OR2G2,PRICKLE1,OR1D2,NTRK1,H2BC13,DGKD,PFN1,FGG,LAMC2,GPR161,CHRM1,DNM2,CAB39L,SMAD5,RHOBTB1,PENK,RRAGA,OR1E2,OR6X1,CDKN2B,PSMD7,WNT9B,GPR84,H2BC4,CDC14A,SDC4,MAPK4,OR6S1,ARHGAP22,SPRY1,OR52B2,SFRP2,OR8B12,CALM2,ADORA3,PPY,INSL5,PDE11A,NPFFR2,LPAR5,H2AC8,FMNL1,LOC100288637,TNFSF10,PIP5K1A,OR9A2,CFLAR,IL2RB,DTX4,RET,ATP6V0A4,OR6N2,TGIF1,KLC2,CHRM3,OR1S2,EEF2K,MAPK14,OR4E2,IGF2BP1,THBS1,PXN,TAS2R50,TGIF2,AGTR1,TLE4,CKAP5,FGF17,MC1R,GNG13,BOC,RSPO3,RGS11,RHOT1,ARHGEF18,RAP1A,OPN5,CHRM2,OR4D11,IL5,OR13C2,NUP107,LPAR3,CCR5,OR4K15,OXT,YWHAH,AATF,IFT122,SYDE2,RASA1,IER3,FGF19,P2RY11,SDC2,DNAJB1,PSMD9,CDH5,COL4A4,UBC,CCL1,PRKCA,ADH1C,RGS1,SPHK1,H4C16,PNOC,FNTB,WASF3,PDE2A,GRIN2A,NCK1,PF4,HBEGF,OR10P1,ACKR3,CREBBP,PRKCB,WNT7A,NCBP2,NPBWR2,PDE3A,SHC1,HCRTR1,TAB2,H4C12,LRP1,OR13C5,RACK1,AKR1B10,RHOU,POLR2A,NMT1,CXCR5,GPR132,VAV1,ADAM12,SPTBN2,PLPPR1,NPY,RGS7,ATP6V1G3,SAA1,MIR1281,OR1A1,DNM3,GNA12,DGKE,PSMD12,PRKCZ,ROR2,BMPR2,PFN2,DGKQ,STAT3,ARPC1A,ADCYAP1R1,VEGFA,OXGR1,NCOR1,ITSN1,TNS4,HHAT,KBTBD7,ADRB1,RTP3,PDE7B,TACR3,RAMP3,OR13D1,AKR1C3,RSPO1,OR11H1,GREM2,RHPN1,KHDRBS1,SEH1L,NPFFR1,ARHGEF35,OR2AE1,USP34,H2BC10,CHN1,FGFR1,RGS21,MAPK6,LAMB2,CLASP2,PRKAR1B,TCF7,CPT1A,RGS18,PSMB3,ARHGEF19,FZD5,ARPC4,TFDP1,JAG1,CTNNBIP1,MTOR,SOCS1,REEP3,RALGDS,DUSP10,CSNK2A1,SHC2,AKT1,ITGA2B,RGS9,PTPN11,OR2W5P,DGKG,PGR,OR52K2,PSMD13,GNA15,AHCTF1,PDYN,NGF,PPP3CC,GPR55,OR2A1,TAS2R43,CASP10,RUVBL1,OR4N2,OR1J2,ATP6V0D2,NUP133,LAMC1,PRKAR1A,ARHGEF10L,RGS22,CLTB,MIR198,GABBR2,PSMD6,RASGRP2,TIA1,BUB1,HTR1D,OR6C70,TCF7L1,OR52I2,OR52M1,ERBB2,NR3C1,MYLK,F11R,OR10G7,THEM4,DUSP2,OR6M1,SEM1,RGS2,TBL1XR1,KIF2A,ROPN1,MTMR4,PDE4D,AVPR1A,SH2D2A,SH3GL1,NRAS,OR2L2,CYP26A1,UCN2,INSR,TAS2R39,E2F5,OR4D10,SPP1,PPP1CB,BMP2,APOC2,REEP4,NEDD4,KIF2B,SOCS6,GHRHR,PPP1CA,BCL2L11,PDE8A,WNT7B,LPAR1,OR56A5,CCR10,GRK3,RBL1,WNT5B,FGFBP1,ARHGAP35,TCIRG1,FES,ARHGEF4,GNB1,ADORA2B,ADCY7,PTPN18,BRAF,NEURL1B,PRKAB2,CDC25C,MRTFA,ARHGEF17,ST3GAL3,RPS6,H3C10,LRP5,OR52H1,TAS2R16,INHBB,OPRM1,OR11H4,MIR1181,ABHD6,LEP,RTP4,OR10Z1,RBX1,FZD9,H3C1,LIMK1,FOXO1,GRM3,TLE2,GNAS,RAMP2,HSPB1,ADCYAP1,PTGFR,ADM,FST,CXCL16,FOXO3,CORT,OR3A1,TIAM2,PIK3R2,OR4D5,SGO1,PLPPR5,CXCR6,CXCL8,PDK1,EPAS1,RLBP1,TRH,OR10S1,TLE1,GNAT1,MARK3,OR6Q1,OR5T1,APOB,ARHGAP31,TGFB1,RHO,TAS1R1,BCO1,SRMS,GRB2,GPR45,WNT11,GFRA1,OR9Q2,PPP2CB,CXCL6,HDAC11,DRD5,NFKBIA,DHH,SHB,LAMA2,SOS1,OR10C1,CDC42EP2,CRH,CAMKMT,GRM5,MGLL,OR9I1,SDC3,ARHGEF1,OR2K2,RXFP1,CUL5,TYK2,FGD3,PRKAA2,OR5D14,SMPD2,OR52E2,CASR,PCSK6,GNRH1,OR7D4,DTX2,PTPRJ,GNG12,PTPN6,KISS1,WDR19,UBE2D1,GRK2,GZMB,ARHGAP25,RASGRF2,ITPR3,LINGO1,RARG,PLCG1,LAMA3,ADGRE3,OR6C6,OR7C2,OR10AD1,ADCY2,JAK2,LRP10,PSMA4,PPP1R15A,ATP6V1B1,OR51I2,PTPN1,OR4N5,MTNR1A,ADCY4,PSMD1,ARAP1,PRKACB,FMNL2,OR1C1,VPS29,H3C8,POLR2L,TACR2,OR6C74,CXCL10,HRAS,WWTR1,PDE4B,ARRB1,OR5K4,TAS2R1,C3,NCK2,PAFAH1B1,MST1,RASGRP3,FGF6,GNRHR,ROCK2,BUB3,KLC1,HTR1E,OR52A1,IQCE,TIAM1,OR4S1,PSMC1,HNRNPA1,OR51B6,AGO4,DSN1,YAP1,CYLD,OMG,IRS2,DNM1,GLI2,ICOS,MATK,OR51A2,ATP6V0E2,GNB3,OR5B21,FGB,FLT1,NMS,GFRA4,NCOA3,DYNC2H1,OR6K6,FGFBP3,CIT,ARHGAP8,GPR25,FNTA,GRB10,TRPC3,WNT10A,NFATC1,PTGER3,HDAC3,OR6C76,WIPF2,TCF7L2,PRKCE,GRM7,RASGRP4,GPR150,PPP2R1B,ARHGEF11,CHUK,VEGFC,OR4K1,STAT1,MYD88,WWOX,H3C6,TAC1,ARAP3,PTHLH,OPRK1,RDH11,OR2T35,OR2AG2,CDK2,CXCR2,OR10J3,ARHGAP18,APC,GNAQ,CD86,PIP4K2A,PLCB2,FAS,ALDH1A2,TAS2R5,CCL20,FGF18,PSMA6,PRR5,RAF1,GPR37,H3-3A,PPP2R1A,CTBP1,NMUR1,LGR5,CHEK1,OR10J5,AKAP9,XCR1,STK4,ITGB1,NCAM1,ARHGAP42,BMPR1A,SCT,SPTBN1,STK11,CLIP1,GRIN2D,CCK,TAAR1,BCR,OR4Q3,EVC2,NRG3,CCRL2,LATS1,PMCH,H4C6,PDE1C,DKK4,SQSTM1,ADRA2A,KIF5A,HCRTR2,POLR2J,NRTN,MOV10,NPBWR1,P2RY1,WWC1,INSL3,GUCA1B,CDC14B,ARHGEF37,PRKAR2B,RHEB,MAPK3,RBCK1,CRHR1,P2RY2,P2RY13,FZD3,DHRS9,NEFL,KIF5B,APH1A,SPOPL,SKA1,ATP6V1C1,MIR4260,GUCA1A,OR11L1,PSMD14,CSNK1G2,MYH14,WNT3,LAMTOR1,HSPG2,RANGAP1,OR6F1,OR9Q1,VRK3,STK3,MAML2,GPR31,P2RY6,RASA2,CIST1,ARPC3,SCAI,HSD17B6,H3C13,GAB2,PRKG2,NTSR1,COL4A3,SMO,ITPR2,IL6,NDE1,CCL28,PDE8B,VIPR1,RELA,OR1B1,THBS3,OR10H1,EVC,GPBAR1,MCHR2,APH1B,MC3R,MDK,DEPDC1B,DNAL4,CHRM4,RGR,ARHGEF5,SH3GL3,FRS3,CDC42,LAMA4,METAP1,LRRK2,HEY1,PTAFR,FGFR2,AXIN1,KAT5,RBFOX2,PSME3,H2BC17,OR1E1,MYC,UTS2,EGFR,ESRP2,TRIM33,MIR1178,OR6B3,LRP2,APOA1,CCDC88C,CXCL5,H2BC21,RANBP2,NPHP4,MAG,WNT6,PDPK1,IL5RA,TMED2,ITPR1,DGKA,OR1F1,CXCL3,MIR4745,SRGAP2,MC2R,RHOD,IGF2,KIF3A,OR5V1,THBS2,PNLIP,PPP3CA,MYL6,GNAZ,RBPJ,OR5K3,FER,FLT4,PAK1,PLCB1,WNT16,DGKZ,OR7D2,GAL,ANXA1,EVL,S1PR1,RDH16,GPR35,PSEN2,GHRH,KNTC1,H2BC9,PRKAR2A,CXCL12,NMUR2,WNT8B,SPC25,ARTN,FSTL3,PDE1A,SMURF1,RGS3,OR10G2,OR52N5,WNT8A,OR2M7,ARHGAP5,GNAT3,RGS9BP,RGS4,ARHGAP15,APOE,ATP6V0E1,OPN3,FGF9,POLR2D,ARHGEF2,IAPP,HTR1B,OR5H6,ADAM10,CLTA,RGS13,CAMK2D,TAS2R7,ARHGAP12,OR1L3,AKT1S1,CASP3,BTC,REEP1,OR1K1,MKS1,REEP5,SMAD9,H2BC7,PSMD11,GNA11,OR2S2,ITGAV,FLRT3,CAV1,DACT1,PTPN12,C5AR1,SH3GL2,FZD10,BCL9L,GGA3,NUP98,MAPK7,PSMA8,PSMD4,FZD2,CSNK2A2,CLIP3,OR1D5,RRAGD,OR11H2,RPS6KA5,H2AC6,TFDP2,F2RL2,OXER1,FFAR1,PSMB4,ULK3,PRKCI,HNRNPM,TNRC6B,CREB1,MAPK8,RSPO2,PSPN,OR5B3,TRIP10,PPP5C,OR2D2,KLK3,S1PR4,OR5H15,RALBP1,EGF,NRG2,OR2B6,BIRC5,KIDINS220,NCOR2,ADRA1B,TAS1R3,KRAS,RAP1B,HGFAC,OR52E8,DGKB,PTH,OR2G6,DLK1,OR52A5,ST3GAL6,SEPTIN7,OR2W1,DNER,PIK3AP1,GNGT2,GRAP,LYN,PSMC6,PRKACA,OR6P1,NCKIPSD,MIR5010,CNKSR1,OR56A1,ACTR2,RTN4,DRD2,BAIAP2,CCR3,GPR176,WASF2,MAPKAP1,RYK,B4GALT1,CCND3,FADD,FZD8,CENPK,PIK3R6,P4HB,CILP,SAV1,CAMK2B,SPINT2,IKBKB,GTF2F2,OR5AK2,REEP6,GPR20,MC5R,NOTCH3,ARHGAP19,CDC37,PIK3R1,SRC,TSHB,OR2B11,ADCY5,GLI3,RDH13,ARHGAP1,RXRG,FLRT1,SST,CSK,S1PR5,DUSP16,ARHGAP30,TAS2R46,PPP2CA,LHCGR,CENPF,DIAPH1,RHOA,H4C3,OR5A1,JAK3,CENPP,VPS35,PRLHR,H2AC19,FN1,OR4K14,GRM6,FZD6,ADAM17,H3C2,WNT2B,NLN,TAS2R10,PRC1,SPRED2,CALM3,DRD4,CHD8,BTRC,RPGRIP1L,BDKRB1,CDK8,NRG4,TAS2R19,GNAI1,RICTOR,RLN2,GPHA2,SH2B1,FURIN,OR10A6,H3C14,ARHGAP11B,ADRA2B,DIAPH3,KDM1A,PKN3,STARD13,VAV2,OPRL1,OR2M4,TTR,PAG1,ADRA1D,TGFBR2,PTGIR,SUFU,H2BC26,PTPRK,CNTN1,LRP8,CASP8,STRAP,OR4B1,GNB4,ZFYVE16,SP1,BAG4,AKT3,PIK3CD,SCRIB,TACR1,OR3A3,H4C1,HRH1,HIF1A,RGS6,HTR7,PPP1R12B,PDK4,RARB,PSMA5,PLPPR3,TNRC6C,FGF8,FPR3,POLR2E,RHOBTB2,RPS27A,KLC3,OR6C4,STRA6,FGD4,COL6A3,GOPC,SEC13,PKN1,SSTR2,SOCS3,ADGRE1,DOCK7,TLE5,NCF4,POMC,MET,NPY2R,DOK1,SYVN1,IL2RA,HES1,LAT,AVP,PTPN2,PTPRU,TTC21B,TNFRSF10B,H2AJ,NCF2,IL17RD,NR4A1,P2RY12,MYO7A,RNF43,DLD,SRGAP1,ERBB4,IL2,ARHGAP20,RNF146,RHOT2,CCR8,TAAR5,ARHGEF7,FFAR3,HPN,KREMEN1,H2AC4,ABHD12,OR5C1,CCR1,DUSP4,FPR2,FYN,TRIB3,ATP6V1E1,EFCAB7,ABI1,OR52N1,AKT2,APOA2,CRK,RANBP10,OR52N2,NPSR1,TEK,GLP2R,AKR1C1,KLHL12,CDC42EP3,KSR2,SPTA1,OR8G2P,PLB1,SOX9,RPTOR,CDH1,SMAD3,PTGDR,NRG1,OR7A5,PRKCH,LRP6,CCKAR,MIR937,CCNT2,GPRC6A,RAMP1,ALDH1A1,OR1G1,TJP1,RIPK1,PTGER1,GNA13,LGR4,FGF10,OR5B17,POFUT1,STAT5A,ANGPT1,MOB1B,ADGRE5,CAMK4,WNT10B,ARF6,ARHGEF10,OR4K5,OR11H6,GRK1,ARHGAP32,OR56B4,OR5H14,GPR39,ZNRF3,GPR37L1,TRHR,TAS2R9,SPTAN1,CALM1,OR1L1,TRAF6,PTEN,PTK6,MAPKAPK3,HDAC9,H2BC6,ARHGEF12,SMAD4,KNL1,ARHGDIB,OR8A1,ARRB2,CGN,NUP85,EDN3,RDH12,RGS20,MAP2K5,RGS14,GRK7,C3AR1,H4C11,AKR1C4,ITGB3BP,GNG7,RBP4,AGRN,PDGFC,FGF3,GLP1R,OR51V1,PELP1,RCVRN,KALRN,RARA,FKBP1A,DAB2IP,PDHX,HHIP,H2AZ1,NOTCH2,OR10A5,OR5AP2,ZWINT,UBA52,OR8B3,OR14I1,MAPK11,FGF20,DVL3,AGO2,HDAC2,SPC24,IQGAP3,YWHAG,APOA4,DRD3,APBB1IP,MYH9,WNT1,PARP1,CUL3,FASLG,NMBR,SDC1,GALR3,NOTUM,EDNRA,PYGO2,STRADA,PDE7A,HEYL,A2M,SPDL1,RIPK2,DUSP8,FGF4,MLST8,PPP1CC,CYFIP1,CALCR,ZFYVE9,SPRED1,OR6A2,VANGL2,ESR1,PIK3CG,FGFR3,NOTCH4,DGKI,PPP2R5B,HES5,H2AC7,CENPH,PIK3C3,DZIP1,CCKBR,LRIG1,LEO1,OR5A2,DHRS4L1,IFT52,FSTL1,RHOF,WDR83,CCNC,TNFRSF1A,AKAP13,CCL23,HDAC4,MAML3,RALA,SH2B3,IFT88,H4C8,OR8B2,KHDRBS3,TAS2R20,ESRP1,OR4D6,GFRA3,ARPC1B,FRAT1,RALB,STRADB,OR1J1,FBXW7,OR2T2,ARHGDIA,SPPL2B,AGO1,PYY,ADCY1,OR2H2,SPRY2,ATP6V1D,ARHGEF3,BDKRB2,RPS6KA2,AP2B1,SFRP1,CD19,TMED5,RPE65,FZD7,RHOQ,OR5K1,ARHGEF15,HRH3,COL6A5,NUMB,OR4D2,WLS,CENPA,ACKR4,PSMB2,RAB6A,HDAC5,IHH,JUNB,NEDD4L,IQGAP2,TAS2R31,PIP5K1C,TAS2R40,GHSR,PTPN3,NUP43,KLK2,INCENP,SMARCA4,ATP2A1,PREX1,GPHB5,ARAP2,TLR9,PTGDR2,S1PR3,H4C13,CXCR4,TNS3,KDR,JAG2,OR1M1,GNB2,KITLG,FABP5,ARHGEF39,OR2AP1,FGA,STAM,GPR15,OXTR,LGR6,XPO1,ABL1,OR52W1,CLTC,MYO9B,PTH2,PDGFRA,RGS10,CRABP1,OBSCN,ARHGEF16,EIF4E,DVL2,SOX2,RASAL1,POLR2B,ZW10,HSD17B1,TIAL1,CAB39,SMPD3,MUC20,HGS,WNT4,OR1L4,SPOP,REEP2,HCRT,MTNR1B,OR8D1,MIR4523,MYL12B,FMNL3,OR10J1,PTH1R,TULP3,KIF2C,MEMO1,OR11G2,RIT2,PARD3,OR1J4,RDH14,HNRNPH1,CCL19,NRP2,OR5M1,IRS1,STAP2,MYL9,OR51T1,CCNT1,PPP2R5C,GFAP,LDLR,PLG,PROKR1,SMAD6,ACTN2,TP53,NDEL1,GPR65,GIP,H2BC15,HEY2,PLK1,OR5M8,SKIL,H2BC3,TRIO,PSMB11,ATP6V1H,CER1,PPP3CB,GSK3A,ARPC5,VEGFB,RXFP4,UTS2B,CDC20,H3C11,FAM13A,TNKS2,SYNGAP1,ST3GAL4,KIF7,GPC6,SKP1,OR4K13,TLE3,RXFP2,DEPDC7,ABR,CSF2RB,PSMB8,CXXC4,LRAT,HTR1F,OR4L1,PTGER4,NRP1,RXFP3,DAGLA,RAPGEF4,LAMB1,PRKAG3,SPTBN5,CAMK2A,OR4K2,PTPRA,TAAR6,CMA1,GPC1,SRF,RAB4A,TRAF1,OR4D1,WNT5A,OR10Q1,OR51L1,KREMEN2,MAD2L1,GAS1,SGO2,GPR32,XCL1,GAB1,ECE1,RBP1,ECT2,TAS2R3,GNG11,ARHGAP23,UCN3,ARHGAP26,OR5H1,SFN,OTUD7B,COL9A2,CASP2,NUF2,USP21,PPP1R14A,NPY1R,ATP6V0D1,WNT3A,DLL4,MEN1,CCR7,DTX1,SERPINE1,CDON,LFNG,COL4A2,OR6B2,COL6A6,TRAT1,COL9A3,CRHBP,PDE3B,GPR18,CCR9,GCGR,PHLPP2,CENPO,CCR2,SPPL2A,MAD1L1,PTBP1,UBB,SCTR,ARHGAP28,FAM13B,EPS15,MAP3K11,GALR1,PSMC3,INS,PRKAA1,DUSP5,H3C7,USP8,KISS1R,PRKCQ,CYP4V2,CSNK1E,GRAP2,OR9G9,KDM4C,PIP4K2B,PMEPA1,CENPU,GRK5,PDHB,ATP6V1G1,PLCB4,CCNK,PSMA1,S1PR2,H2BC8,RAC3,TAX1BP1,OR2A4,OR2AT4,MAPRE1,CXCL11,FZD1,PLAT,NPY4R,RRAGC,SCUBE2,OPN4,ACVR1C,QRFPR,STAT5B,NUP160,FGFR4,PIK3CB,PIK3R5,OR10K1,ABI2,HTR5A,TAS2R4,GRM2,CRHR2,OR9K2,H3-4,MAPK1,LEPR,OR1L6,CLPS,CFTR,OR2A5,VIPR2,SRGAP3,FSHB,HRH2,GRK4,EIF4G1,OR52K1,F2R,TAAR3P,B9D2,MAPK12,TAS2R41,ITGA2,OR5AN1,SMAD2,PKN2,TRPC6,GNA14,OR6K3,NGFR,FLRT2,PPP3R1,E2F4,GNAI2,CCNE1,OR6C2,MEF2C,ADCY10,ROR1,CCL25,ASH2L,OR5B12,FGF23,ERBB3,PTCH2,AP2A2,MIR4758,RRH,PTGER2,OR6C75,ATP6V1C2,ARHGAP17,HEBP1,OR2F2,LAMTOR4,CAMK2G,OR51E1,MCF2L,PROK2,CHN2,PSME1,ADRB2,LAMB3,MIR5004,OR6C1,PGF,OR6C68,PTCH1,H3C3,PDE6A,PHLPP1,NMU,OR8D2,RAPGEF2,OR10T2,OR8D4,PRKAG2,ARHGAP21,PDE10A,RAPGEF3,DOCK1,SOX7,KIF14,C5,ITGB3,SHC3,PTK2B,GUCY2D,RFNG,PIK3R4,GDI2,OR6C65,CENPN,AGO3,SYDE1,MIR197,OR13G1,OR2Z1,CX3CR1,ADCY8,TAAR8,AMOTL2,ACTR3,OR4D9,RCC2,ITGA3,MYO9A,DUSP1,NFKB1,OR1F2P,DLAT,PMF1,ATP6V0B,ADRA1A,LAMTOR5,PDE4C,ACVR1B,ALDH1A3,TRRAP,CD28,NPY5R,OR6C3,SPTBN4,SSTR1,OR5H2,THBS4,GNB5,OR6Y1,OR4F29,GPIHBP1,MC4R,OR13A1,INPP5B,FPR1,SNW1,WDR35,SHH,RLN3,OR1I1,OR13C9,TAS2R13,PLXNB1,BIRC2,CNR1,NGEF,F2RL1,CCL16,IQGAP1,KAT2B,METAP2,OR1S1,PSMD5,ACTB,ACVR2B,TRADD,KIT,OR2T27,TNFAIP3,OR13J1,GHRL,AGT,DKK2,IFT172,ARHGAP27,SFPQ,RTP1,ATP2A3,OR2C1,PAQR3,AP2S1,CASP9,CSNK1A1,CTNNB1,OR10H5,SOX13,APP,CCL27,OR7E24,RAG2,PSMA3,WASL,PDK2,ACTG1,EP300,CYBA,CTNND1,FSHR,GRAPL,PSMB10,OR5T3,RGS17,RHOV,ADRA2C,PRKG1,NTS,RHOB,WIPF1,GRM4,MDM2,EIF4B,PSMB9,CDKN1A,HDAC1,SOS2,ATP6V1E2,OR12D2,CYFIP2,TNKS,VIP,OR6T1,CHRM5,CNR2,CBL,LAMA1,DAGLB,FFAR4,RASAL2,PCSK5,OR7A17,RSPO4,OR9A4,PTK2,DKK1,AXIN2,ADORA1,PRLH,HRH4,GPC5,NF1,TRPC7,FGF2,AHCYL1,JUP,HNRNPF,GNG5,OR4M1,EDN2,OR10H4,INTU,RGS5,PPP2R5A,OR3A2,ARHGAP44,AP2M1,YWHAB,OR14J1,LTB4R,KHDRBS2,ARHGEF40,MYH11,GPER1,PDGFRB,GPNMB,GFRA2,BRK1,DGKH,UCN,EPS15L1,RHOG,WNT2,ADCY6,SOST,MOB1A,YWHAE,GNAT2,RASGRF1,H4C2,CYSLTR2,INHBA,RPS6KA1,WASF1,BRAP,OR51I1,MYH10,PDE6B,TNRC6A,PRKAB1,GALNT3,NOX3,PSMC4,RASA4,RDH5,HTR1A,ITCH,ARHGAP45,AVPR1B,MMP9,HTR2B,APLNR,RASGEF1A,SLC24A1,ARHGAP29,NEURL1,GABBR1,HDAC7,DLG4,LIMK2,DRAP1,COL4A1,OR5AU1,TAGAP,PPP2R5D,OR2J3,SUCNR1,LAMA5,OR51E2,MAP2K2,IL3,H2BC11,OR13C4,OR4C12,JUN,ERBIN,SOX17,EPN1,CENPM,OR8K3,RACGAP1,FGFRL1,BCL9,RAG1,ARHGAP40,CCL21,SOX6,CSF2,LPL,SKI,H2BC5,HGF,PIP4K2C,RPS6KB2,SNX3,ADH1A,FGF22,DVL1,GSK3B,ATP6V0A2,CDKN1B,ATP6V1B2,CD80,IGF1R,YWHAQ,E2F3,PDGFB,CXCL2,ARHGAP24,VCL,ABCA4,RPS6KB1,ARHGAP11A,FGFBP2,ACVR2A,ARHGEF26,SMAD7,OR4F16,RNF111,GRK6,PTH2R,OR2B2,ADRB3,PPP2R5E,VWF,YES1,PSMB5,GNAL,CDK5,NUP37,WIF1,OR9G4,CALCB,DHRS4,EDN1,PPP1R12A,OR10A3,OR2V2,OR1L8,TSC1,BIRC3,DLC1,SSTR4,RTKN,ADCY9,OR2Y1,OR10A7,ZWILCH,FGF1,P2RY14,GNG4,LAMC3,H4C4,SYK,UTS2R,PSME4,NSMAF,SOX4,SPINT1,MFNG,POLR2C,H4C5,OR52R1,MAPK13,SPTB,OR8U3,NPS,CRABP2,PRKAG1,RGS12,GIPR,KLC4,SEL1L,RAC1,PIK3R3,KEL,PSMB7,EIF4EBP1,GNG2,ADCY3,GAST,IFT57,STUB1,AP2A1,PROKR2,CTNNA1,ACKR1,TSC2,PEBP1,CXCL13,CALCRL,ELMO2,LEF1,OR10H2,PHB1,WWP1,ARHGAP9,STAM2,PDE1B,TAX1BP3,OR13C8,LATS2,HTR2A,RBBP5,HSP90AA1,GDNF,MAP3K7,DHRS3,MAML1,F2,LAMTOR3,LPAR6,RHOJ,ARHGAP10,KIF18A,PDGFD,PLPPR4,SMAD1,CX3CL1,GRM1,RASAL3,HTR6,OR7C1,RGS19,CD55,CTTN,H2AZ2,CDC73,BMPR1B,PRKCD,NAPEPLD,EDNRB,ADGRE2,IL6ST,FRS2,OR52B6,CBY1,SAG,WNT9A,PSMD8,KTN1,TNFRSF10A,ADORA2A,RGS8,ELMO1,FZD4,STAT6,H3-3B,CALCA,OR1Q1,VPS26A,CLASP1,LCK,CCR6,CYP26B1,TAAR2,MLN,FFAR2,AMOTL1,GALR2,OR2J2,AURKB,PLCB3,OR5AC2,HCAR2,NCSTN,TAS2R38,SPRED3,MADD,NSL1,ATP6V1A,XCL2,PSMC2,GTF2F1,OS9,RBP2,DUSP7,FGF5,TSHR,PLPPR2,PIP5K1B,GCG,CENPE,NOS3,MEF2A,POLR2K,USP15,LHB,CENPT,H4C14,NCOA2,TAS1R2,COL9A1,EREG,HDAC10,TERT,OR5B2,TJP2,PSMF1,SMURF2,OR51D1,NTSR2,NCBP1,NTRK2,OTULIN,PSAP,BCAR1,RDH8,GPR183,OR10W1,HECW1,GNGT1,GRIN2B,DRD1,CCR4,MIB2,DUSP6,YWHAZ,OR56A4,RGSL1,OR52J3,DAAM1,RBP3,ATF1,TBXA2R,PDE6G,PPM1A,TAB1,OR2V1,CUL1,USP2,MAPKAPK2,RHOH,NDC80,UBE2D3,CCL5
R-HSA-111453	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	0.983434362072128	-0.0167043825035864	9	6	0.000664157626743414	9034	10285	90427,10018,27113,598,5366,596	BMF,BCL2L11,BBC3,BCL2L1,PMAIP1,BCL2
R-HSA-163765	ChREBP activates metabolic gene expression	0.983434362072128	-0.0167043825035864	9	6	0.000664157626743414	9034	10285	32,51085,31,47,2194,5313	ACACB,MLXIPL,ACACA,ACLY,FASN,PKLR
R-HSA-1268020	Mitochondrial protein import	0.984878469402882	-0.0152370267390204	62	49	0.00542395395173788	9034	10285	197257,401505,84269,498,7416,9868,29090,388753,90639,134266,9512,3313,51025,50,100287932,506,150274,100188893,10452,3329,79145,9804,291,1431,131474,54927,26519,2671,56993,26520,80273,26517,27235,8604,92609,29928,10469,10165,26515,516,2395,10440,10651,56942,400916,54543,617,25813,131118	LDHD,TOMM5,CHCHD5,ATP5F1A,VDAC1,TOMM70,TIMM21,COA6,COX19,GRPEL2,PMPCB,HSPA9,PAM16,ACO2,TIMM23,ATP5F1B,HSCB,TOMM6,TOMM40,HSPD1,CHCHD7,TOMM20,SLC25A4,CS,CHCHD4,CHCHD3,TIMM10,GFER,TOMM22,TIMM9,GRPEL1,TIMM13,COQ2,SLC25A12,TIMM50,TIMM22,TIMM44,SLC25A13,TIMM10B,ATP5MC1,FXN,TIMM17A,MTX2,CMC2,CHCHD10,TOMM7,BCS1L,SAMM50,DNAJC19
R-HSA-71262	Carnitine synthesis	0.985153402074493	-0.0149579117892814	5	3	0.000332078813371707	9034	10285	223,8424,6470	ALDH9A1,BBOX1,SHMT1
R-HSA-114294	Activation, translocation and oligomerization of BAX	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	581	BAX
R-HSA-480985	Synthesis of dolichyl-phosphate-glucose	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	29880	ALG5
R-HSA-3359473	Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	27249	MMADHC
R-HSA-111452	Activation and oligomerization of BAK protein	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	578	BAK1
R-HSA-380612	Metabolism of serotonin	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	217	ALDH2
R-HSA-168277	Influenza Virus Induced Apoptosis	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	7040	TGFB1
R-HSA-3359485	Defective CD320 causes methylmalonic aciduria	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	51293	CD320
R-HSA-5688354	Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	6439	SFTPB
R-HSA-3858516	Glycogen storage disease type 0 (liver GYS2)	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	2998	GYS2
R-HSA-5357609	Glycogen storage disease type II (GAA)	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	2992	GYG1
R-HSA-5602636	IKBKB deficiency causes SCID	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	1147	CHUK
R-HSA-73930	Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	5423	POLB
R-HSA-141334	PAOs oxidise polyamines to amines	0.985215693452602	-0.0148946836577892	2	1	0.000110692937790569	9034	10285	54498	SMOX
R-HSA-2564830	Cytosolic iron-sulfur cluster assembly	0.985333829369351	-0.0147747821627775	13	9	0.000996236440115121	9034	10285	64210,2068,64428,83990,57019,9391,4682,5424,51750	MMS19,ERCC2,CIAO3,BRIP1,CIAPIN1,CIAO1,NUBP1,POLD1,RTEL1
R-HSA-212165	Epigenetic regulation of gene expression	0.985572795402266	-0.0145322886513317	151	124	0.0137259242860306	9034	10285	8359,23411,54815,25942,29947,7343,51082,9219,1107,100302237,8344,2071,22823,3020,2965,23378,2967,8726,4641,53615,8354,128312,26147,2068,8362,8349,57504,8932,5252,2074,8370,8341,3018,126961,8365,8367,6996,5440,8353,8348,8366,7913,121504,23309,200424,8334,80312,25885,3013,9014,653604,8968,902,8358,1788,5928,8339,79101,8343,7270,64426,84172,8360,8467,79685,29128,64425,9533,8352,8335,10919,2968,23451,51742,1108,723790,8364,9031,29115,57459,9188,10284,55766,79595,3021,3012,2932,221830,10514,3066,9015,4331,3065,54790,8350,94239,3720,8361,121536,8347,8345,404672,2033,3017,3015,8368,8346,1022,8850,1786,11335,5434,5441,2146,8357,8819,8970,8355,10849,8363,23512,11176,8340,60	H4C1,SIRT1,GATAD2A,SIN3A,DNMT3L,UBTF,POLR1D,MTA2,CHD3,MIR1281,H2BC6,ERCC3,MTF2,H3-3A,GTF2H1,RRP8,GTF2H3,EED,MYO1C,MBD3,H3C11,H2BC26,PHF19,ERCC2,H4C12,H2BC21,MTA3,MBD2,PHF1,ERCC6,H4C14,H2BC15,H2BC3,H3C14,H4C8,H4C5,TDG,POLR2K,H3C6,H2BC17,H4C2,DEK,H4C16,SIN3B,TET3,H2AC6,TET1,POLR1A,H2AC7,TAF1B,H3C13,H3C7,CCNH,H3C2,DNMT3A,RBBP4,H2BC8,TAF1D,H2BC7,TTF1,SUDS3,POLR1B,H4C4,SMARCA5,SAP30L,UHRF1,POLR1E,POLR1C,H3C3,H2AC4,EHMT2,GTF2H4,SF3B1,ARID4B,CHD4,H2AC19,H4C3,BAZ1B,SAP30BP,GATAD2B,DDX21,SAP18,H2AJ,SAP130,H3-3B,H2AC8,GSK3B,POLR1F,MYBBP1A,HDAC2,TAF1A,MNAT1,HDAC1,TET2,H3C1,H2AZ2,JARID2,H4C6,AEBP2,H2BC4,H2BC9,GTF2H5,EP300,H2BC5,H2AZ1,H4C13,H2BC10,CDK7,KAT2B,DNMT1,CBX3,POLR2E,POLR2L,EZH2,H3C10,SAP30,H2BC11,H3C8,POLR1G,H4C11,SUZ12,BAZ2A,H2BC13,ACTB
R-HSA-167243	Tat-mediated HIV elongation arrest and recovery	0.986829319500517	-0.0132581830734295	38	29	0.0032100951959265	9034	10285	7936,11198,100126332,9150,6829,6923,51497,5440,5433,5432,5430,5439,162699,6917,100506888,51224,6921,5431,7469,5441,904,6749,8178,6924,2962,100302242,5434,2963,6827	NELFE,SUPT16H,MIR943,CTDP1,SUPT5H,ELOB,NELFCD,POLR2K,POLR2D,POLR2C,POLR2A,POLR2J,ELOA3P,TCEA1,ELOA3DP,ELOA2,ELOC,POLR2B,NELFA,POLR2L,CCNT1,SSRP1,ELL,ELOA,GTF2F1,MIR1236,POLR2E,GTF2F2,SUPT4H1
R-HSA-5689901	Metalloprotease DUBs	0.986829319500517	-0.0132581830734295	38	29	0.0032100951959265	9034	10285	8335,8969,7314,10617,7316,9577,100302237,2033,114803,8027,7311,29086,723790,8334,23172,57559,8850,3013,6233,3012,84142,114548,92815,672,8332,221613,580,10213,51720	H2AC4,H2AC11,UBB,STAMBP,UBC,BABAM2,MIR1281,EP300,MYSM1,STAM,UBA52,BABAM1,H2AC19,H2AC6,ABRAXAS2,STAMBPL1,KAT2B,H2AC7,RPS27A,H2AC8,ABRAXAS1,NLRP3,H2AC25,BRCA1,H2AC16,H2AC1,BARD1,PSMD14,UIMC1
R-HSA-167238	Pausing and recovery of Tat-mediated HIV elongation	0.986829319500517	-0.0132581830734295	38	29	0.0032100951959265	9034	10285	9150,6829,100126332,7936,11198,100506888,6917,51224,5439,5430,5432,162699,5440,5433,6923,51497,6749,7469,904,5441,5431,6921,6827,2963,100302242,2962,5434,6924,8178	CTDP1,SUPT5H,MIR943,NELFE,SUPT16H,ELOA3DP,TCEA1,ELOA2,POLR2J,POLR2A,POLR2C,ELOA3P,POLR2K,POLR2D,ELOB,NELFCD,SSRP1,NELFA,CCNT1,POLR2L,POLR2B,ELOC,SUPT4H1,GTF2F2,MIR1236,GTF2F1,POLR2E,ELOA,ELL
R-HSA-72766	Translation	0.988160982185143	-0.0119096570727763	162	133	0.0147221607261457	9034	10285	8890,1650,60559,27335,10952,1974,6207,6729,6205,6230,6133,8669,6129,6206,6154,90701,6144,8664,6731,1937,23480,200916,6138,6159,23478,6235,9045,1936,6124,6143,1983,8892,6175,6139,6160,1978,51504,728689,7458,6232,6176,51386,6123,140801,8668,6166,6185,6728,25873,6227,8661,1981,3921,6167,6734,6165,6202,6128,55176,6130,6169,29104,6233,6201,327,1917,1915,9789,8662,6142,8893,6122,6208,6189,6217,6730,3646,6229,9669,4736,6194,23521,6136,6210,6164,6135,6137,6152,6231,6224,7311,1938,6184,2935,10480,8891,6155,6157,29927,9349,6156,51121,11224,116832,6223,6204,1977,1975,26986,6125,51065,6747,6234,6745,6181,6168,6726,1967,23471,8894,8666,6146,1965,6746,6228,6727,6209,6188,6161,8665,2107,8667,58477	EIF2B4,DDOST,SPCS3,EIF3K,SEC61B,EIF4A2,RPS13,SRP54,RPS11,RPS25,RPL9,EIF3J,RPL7,RPS12,RPL26,SEC11C,RPL21,EIF3D,SRP72,EEF1G,SEC61G,RPL22L1,RPL15,RPL29,SEC11A,RPS29,RPL14,EEF1D,RPL4,RPL19,EIF5,EIF2B2,RPLP0,RPL17,RPL31,EIF4EBP1,TRMT112,EIF3CL,EIF4H,RPS27,RPLP1,EIF3L,RPL3L,RPL10L,EIF3I,RPL36AL,RPN2,SRP19,RPL36,RPS21,EIF3A,EIF4G1,RPSA,RPL37,SRPRA,RPL35A,RPS8,RPL6,SEC61A2,RPL7A,RPL38,N6AMT1,RPS27A,RPS7,APEH,EEF1A2,EEF1A1,SPCS2,EIF3B,RPL18A,EIF2B5,RPL3,RPS14,RPS3A,RPS16,SRP68,EIF3E,RPS24,EIF5B,RPL10A,RPS6,RPL13A,RPL12,RPS15A,RPL34,RPL11,RPL13,RPL24,RPS26,RPS20,UBA52,EEF2,RPN1,GSPT1,EIF3M,EIF2B3,RPL27,RPL27A,SEC61A1,RPL23,RPL30,RPL26L1,RPL35,RPL39L,RPS19,RPS10,EIF4E,EIF4B,PABPC1,RPL5,RPS27L,SSR3,RPS28,SSR1,RPLP2,RPL37A,SRP9,EIF2B1,TRAM1,EIF2S2,EIF3G,RPL22,EIF2S1,SSR2,RPS23,SRP14,RPS15,RPS3,RPL32,EIF3F,ETF1,EIF3H,SRPRB
R-HSA-606279	Deposition of new CENPA-containing nucleosomes at the centromere	0.988562523865725	-0.0115033871165827	72	57	0.00630949745406243	9034	10285	8349,128312,8362,3012,51773,55320,55766,4869,8364,401541,54069,8344,1058,723790,57082,1060,8359,11339,8335,79172,8467,8363,79682,8340,23421,5928,8339,8343,8970,8360,79019,8607,64946,3013,201254,3017,3015,8368,387103,8346,8334,8348,64105,8366,121504,8361,55839,55355,8347,80152,8345,8341,8370,94239,3018,8365,8367	H2BC21,H2BC26,H4C12,H2AC8,RSF1,MIS18BP1,H2AJ,NPM1,H4C3,CENPP,MIS18A,H2BC6,CENPA,H2AC19,KNL1,CENPC,H4C1,OIP5,H2AC4,CENPO,SMARCA5,H4C11,CENPU,H2BC13,ITGB3BP,RBBP4,H2BC8,H2BC7,H2BC11,H4C4,CENPM,RUVBL1,CENPH,H2AC7,CENPX,H2BC5,H2AZ1,H4C13,CENPW,H2BC10,H2AC6,H2BC17,CENPK,H4C2,H4C16,H4C6,CENPN,HJURP,H2BC4,CENPT,H2BC9,H2BC15,H4C14,H2AZ2,H2BC3,H4C8,H4C5
R-HSA-774815	Nucleosome assembly	0.988562523865725	-0.0115033871165827	72	57	0.00630949745406243	9034	10285	64946,3013,201254,8607,8360,79019,8339,5928,8970,8343,8340,23421,8467,8363,79682,3018,8365,8367,8370,8341,94239,8347,80152,8345,8361,55839,55355,8366,121504,8348,64105,8346,8334,3017,3015,387103,8368,4869,55320,55766,51773,3012,8362,128312,8349,8359,11339,8335,79172,1060,723790,57082,54069,8344,1058,401541,8364	CENPH,H2AC7,CENPX,RUVBL1,H4C4,CENPM,H2BC8,RBBP4,H2BC11,H2BC7,H2BC13,ITGB3BP,SMARCA5,H4C11,CENPU,H2BC3,H4C8,H4C5,H4C14,H2BC15,H2AZ2,H2BC4,CENPT,H2BC9,H4C6,CENPN,HJURP,H4C2,H4C16,H2BC17,CENPK,H2BC10,H2AC6,H2BC5,H2AZ1,CENPW,H4C13,NPM1,MIS18BP1,H2AJ,RSF1,H2AC8,H4C12,H2BC26,H2BC21,H4C1,OIP5,H2AC4,CENPO,CENPC,H2AC19,KNL1,MIS18A,H2BC6,CENPA,CENPP,H4C3
R-HSA-73886	Chromosome Maintenance	0.988995265602102	-0.0110657344263913	109	88	0.00974097852557007	9034	10285	5982,26277,1058,8344,54069,57082,1060,8290,8359,8349,128312,8362,10714,2237,4869,387103,8334,1763,7015,54107,5557,8348,121504,8366,55135,10856,55839,55355,55651,80152,8341,8370,8367,8365,3018,79682,56655,8467,6117,8343,23649,8339,5928,8360,5985,8607,5427,201254,3013,64946,57804,8364,401541,723790,79172,8335,11339,6119,7014,5424,5984,3012,51773,25913,3978,55320,55766,8368,3015,3017,8346,64105,5983,8361,8345,5558,8347,94239,8363,23421,8340,8970,79019,65057,6118,7013,5981,5111	RFC2,TINF2,CENPA,H2BC6,MIS18A,KNL1,CENPC,H3-4,H4C1,H2BC21,H2BC26,H4C12,POLD3,FEN1,NPM1,CENPW,H2AC6,DNA2,TERT,POLE3,PRIM1,H2BC17,H4C16,H4C2,WRAP53,RUVBL2,CENPN,HJURP,NHP2,CENPT,H2BC15,H4C14,H4C5,H4C8,H2BC3,CENPU,POLE4,SMARCA5,RPA1,H2BC7,POLA2,H2BC8,RBBP4,H4C4,RFC5,RUVBL1,POLE2,CENPX,H2AC7,CENPH,POLD4,H4C3,CENPP,H2AC19,CENPO,H2AC4,OIP5,RPA3,TERF2,POLD1,RFC4,H2AC8,RSF1,POT1,LIG1,MIS18BP1,H2AJ,H4C13,H2AZ1,H2BC5,H2BC10,CENPK,RFC3,H4C6,H2BC9,PRIM2,H2BC4,H2AZ2,H4C11,ITGB3BP,H2BC13,H2BC11,CENPM,ACD,RPA2,TERF1,RFC1,PCNA
R-HSA-417957	P2Y receptors	0.98998700428245	-0.0100634629270857	12	8	0.000885543502324552	9034	10285	5031,64805,10161,5028,53829,5029,5032,9934	P2RY6,P2RY12,LPAR6,P2RY1,P2RY13,P2RY2,P2RY11,P2RY14
R-HSA-2468052	Establishment of Sister Chromatid Cohesion	0.98998700428245	-0.0100634629270857	12	8	0.000885543502324552	9034	10285	10274,113130,9126,23047,157570,5885,23244,23063	STAG1,CDCA5,SMC3,PDS5B,ESCO2,RAD21,PDS5A,WAPL
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	0.98998700428245	-0.0100634629270857	12	8	0.000885543502324552	9034	10285	7189,7335,4615,51135,170506,54106,3665,7334	TRAF6,UBE2V1,MYD88,IRAK4,DHX36,TLR9,IRF7,UBE2N
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	0.990560142104669	-0.00948469575230458	53	41	0.00453841044941333	9034	10285	3921,8661,6224,6231,6228,6209,6235,6202,6188,8665,10480,8667,51065,8664,8668,6234,6210,6227,1965,8894,8666,6223,6208,51386,6189,6204,3646,6206,6217,6229,6194,27335,6233,728689,6201,6207,6232,6230,6205,8669,8662	RPSA,EIF3A,RPS20,RPS26,RPS23,RPS15,RPS29,RPS8,RPS3,EIF3F,EIF3M,EIF3H,RPS27L,EIF3D,EIF3I,RPS28,RPS15A,RPS21,EIF2S1,EIF2S2,EIF3G,RPS19,RPS14,EIF3L,RPS3A,RPS10,EIF3E,RPS12,RPS16,RPS24,RPS6,EIF3K,RPS27A,EIF3CL,RPS7,RPS13,RPS27,RPS25,RPS11,EIF3J,EIF3B
R-HSA-75067	Processing of Capped Intronless Pre-mRNA	0.990566009983997	-0.00947877197069951	31	23	0.00254593756918309	9034	10285	23283,22916,10978,25888,8106,84967,8189,10914,10898,4686,134353,51692,7884,6636,55339,81608,1479,6628,6637,79869,6635,51585,53981	CSTF2T,NCBP2,CLP1,ZNF473,PABPN1,LSM10,SYMPK,PAPOLA,CPSF4,NCBP1,LSM11,CPSF3,SLBP,SNRPF,WDR33,FIP1L1,CSTF3,SNRPB,SNRPG,CPSF7,SNRPE,PCF11,CPSF2
R-HSA-2408557	Selenocysteine synthesis	0.990591611937347	-0.00945292652249429	95	76	0.00841266327208324	9034	10285	6129,6122,6208,6189,6206,6217,6229,6154,6194,4736,6130,6233,6169,6201,6207,6230,6205,6133,6142,79048,6135,6152,6159,6137,7311,6231,6224,9045,6235,6124,23521,6144,6136,118672,6210,6164,200916,6138,6176,11224,51121,6156,6223,116832,6204,6123,140801,6155,6143,6175,6157,6139,60678,51091,6160,6232,6301,9349,3921,6167,6165,6228,6209,6202,6161,6188,6128,51065,6125,6234,6166,25873,6168,6181,6227,6146	RPL7,RPL3,RPS14,RPS3A,RPS12,RPS16,RPS24,RPL26,RPS6,RPL10A,RPL7A,RPS27A,RPL38,RPS7,RPS13,RPS25,RPS11,RPL9,RPL18A,SECISBP2,RPL11,RPL24,RPL29,RPL13,UBA52,RPS26,RPS20,RPL14,RPS29,RPL4,RPL13A,RPL21,RPL12,PSTK,RPS15A,RPL34,RPL22L1,RPL15,RPLP1,RPL35,RPL26L1,RPL30,RPS19,RPL39L,RPS10,RPL3L,RPL10L,RPL27,RPL19,RPLP0,RPL27A,RPL17,EEFSEC,SEPSECS,RPL31,RPS27,SARS1,RPL23,RPSA,RPL37,RPL35A,RPS23,RPS15,RPS8,RPL32,RPS3,RPL6,RPS27L,RPL5,RPS28,RPL36AL,RPL36,RPL37A,RPLP2,RPS21,RPL22
R-HSA-72203	Processing of Capped Intron-Containing Pre-mRNA	0.990740517157878	-0.00930261833476135	247	205	0.0226920522470666	9034	10285	23451,79869,57703,55706,5725,6627,9416,2521,9295,3312,2963,55599,84950,29107,10946,51639,23165,3184,100101267,129401,6635,7175,53981,10465,7536,10907,5439,51593,6636,100616394,23658,23020,10262,407043,4809,3183,10949,23398,54883,1665,9343,220988,79902,3181,11193,9818,51690,100616459,154007,5430,6628,51503,6430,9589,84991,4686,23225,23511,23279,22916,5903,23283,5440,10212,84248,84271,4116,10482,9631,6631,10450,8896,9883,8021,10285,5356,4904,6629,3185,2962,56339,25949,6426,57122,84321,10772,11157,22827,11017,9716,10978,3190,6633,10236,26097,5433,6626,57819,6429,22794,56259,24144,83443,9688,6625,79023,10569,55339,23350,51692,79622,10992,9092,27258,80145,10898,9984,6431,53371,10283,85437,5431,9410,51645,1977,6936,51362,988,6637,7307,26121,3191,1479,23524,81929,81608,9877,10189,1660,8563,3178,7884,4927,10594,5434,6428,22826,55110,348995,10081,57721,10291,6434,11338,5441,55749,25804,1993,55660,11097,8449,22938,84844,9128,10713,10914,4670,57461,11325,5094,9972,9775,3192,8683,9879,51585,4928,51729,5093,8086,5432,10250,24148,11100,6432,51691,10286,3187,55746,10421,10181,23517,10523,1994,8106,8189,84324,11066,5546,55954,57794,55696,9129,10762,23636	SF3B1,CPSF7,CWC22,NDC1,PTBP1,SNRPA1,DDX23,FUS,SRSF11,HSPA8,GTF2F2,RNPC3,PRPF38A,NXT1,SF3A3,SF3B6,NUP205,HNRNPD,POM121C,NUP35,SNRPE,TPR,CPSF2,PPIH,SF1,TXNL4A,POLR2J,SRRT,SNRPF,MIR4444-1,LSM5,SNRNP200,SF3B4,MIR7-1,SNU13,HNRNPC,HNRNPA0,PPWD1,CWC25,DHX15,EFTUD2,HNRNPA3,NUP85,HNRNPA2B1,WBP4,NUP58,LSM7,MIR4745,SNRNP48,POLR2A,SNRPB,CWC15,SRSF5,WTAP,RBM17,NCBP1,NUP210,NUP188,NUP160,NCBP2,RANBP2,CSTF2T,POLR2K,DDX39A,FYTTD1,POLDIP3,MAGOH,NXF1,NUP155,SNRPC,PPIE,BUD31,POM121,NUP214,SMNDC1,PLRG1,YBX1,SNRPB2,HNRNPF,GTF2F1,METTL3,SYF2,SRSF1,NUP107,THOC3,SRSF10,LSM6,PUF60,SNRNP27,AQR,CLP1,HNRNPK,SNRPD2,HNRNPR,CHTOP,POLR2D,SNRPA,LSM2,SRSF4,CASC3,CTNNBL1,TFIP11,SF3B5,NUP93,SNRNP70,NUP37,SLU7,WDR33,U2SURP,CPSF3,SNRNP25,SF3B2,SART1,LSM3,THOC7,CPSF4,THOC1,SRSF6,NUP54,CWC27,ZCRB1,POLR2B,SNRNP40,PPIL1,EIF4E,GCFC2,CDC40,CDC5L,SNRPG,U2AF1,PRPF31,HNRNPL,CSTF3,SRRM2,SEH1L,FIP1L1,ZC3H11A,ALYREF,DHX9,THOC5,HNRNPA1,SLBP,NUP88,PRPF8,POLR2E,SRSF3,DNAJC8,MAGOHB,NUP43,PDCD7,METTL14,SF3A1,TRA2B,U2AF2,POLR2L,CCAR1,LSM4,ELAVL2,PRPF40A,NUP42,DHX16,SNW1,PHF5A,PRPF4,USP39,PAPOLA,HNRNPM,ISY1,DDX42,PCBP2,NUP153,EIF4A3,HNRNPU,SRSF9,DDX46,PCF11,NUP98,WBP11,PCBP1,AAAS,POLR2C,SRRM1,PRPF6,HNRNPUL1,SRSF7,LSM8,BCAS2,HNRNPH1,NUP133,CD2BP2,RBM5,MTREX,CHERP,ELAVL1,PABPN1,SYMPK,SARNP,SNRNP35,PRCC,ZMAT5,SUGP1,RBM22,PRPF3,NUP50,NUP62
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	0.990808539698775	-0.00923396241056094	179	147	0.0162718618552136	9034	10285	140801,6123,11103,57647,27042,6176,54555,6232,23160,6160,5394,6139,6175,6143,6128,8602,84128,6202,55272,6165,6167,2091,11340,57050,3921,5822,55127,9790,1453,6227,25873,6166,51077,65083,56902,6154,10438,6206,26168,79707,118460,6129,6133,11056,10200,6230,6205,1454,51096,23517,6207,57418,6124,90459,9045,6235,51602,22803,6159,55720,6138,200916,5393,9724,6144,23404,8780,6204,116832,23016,6223,6156,11224,51121,9277,10199,9349,25926,705,83732,84916,6157,6155,6188,27340,6161,6209,6228,25879,51118,79897,6146,6181,6168,10528,79050,51010,6234,6125,51065,4736,10799,6194,6229,81875,6217,10607,6189,6208,10171,6122,84946,6142,55813,10556,92856,55781,88745,6201,22984,6169,6233,6130,134430,10885,54913,28987,6231,6224,7311,6137,4809,54881,55759,6152,6135,27043,6164,84135,6210,11102,9136,6136,23521,56915,27341,51202	RPL10L,RPL3L,KRR1,DHX37,UTP25,RPLP1,DDX49,RPS27,WDR43,RPL31,EXOSC10,RPL17,RPLP0,RPL19,RPL6,NOP14,WDR75,RPS8,IMP3,RPL35A,RPL37,FBL,EXOSC8,UTP3,RPSA,PWP2,HEATR1,BMS1,CSNK1D,RPS21,RPL36,RPL36AL,FCF1,NOL6,PNO1,RPL26,C1D,RPS12,SENP3,NOL9,EXOSC6,RPL7,RPL9,DDX52,MPHOSPH6,RPS25,RPS11,CSNK1E,UTP18,MTREX,RPS13,WDR18,RPL4,ERI1,RPL14,RPS29,NOP58,XRN2,RPL29,TSR1,RPL15,RPL22L1,EXOSC9,UTP14C,RPL21,EXOSC2,RIOK3,RPS10,RPL39L,EXOSC7,RPS19,RPL30,RPL35,RPL26L1,WDR46,MPHOSPH10,RPL23,NOL11,BYSL,RIOK1,UTP4,RPL27A,RPL27,RPS3,UTP20,RPL32,RPS15,RPS23,DCAF13,UTP11,RPP21,RPL22,RPLP2,RPL37A,NOP56,NOC4L,EXOSC3,RPS28,RPL5,RPS27L,RPL10A,RPP40,RPS6,RPS24,ISG20L2,RPS16,TBL3,RPS3A,RPS14,RCL1,RPL3,LTV1,RPL18A,UTP6,RPP30,IMP4,RIOK2,RRP36,RPS7,PDCD11,RPL38,RPS27A,RPL7A,WDR36,WDR3,RPP25,NOB1,RPS26,RPS20,UBA52,RPL13,SNU13,TEX10,WDR12,RPL24,RPL11,PELP1,RPL34,UTP15,RPS15A,RPP14,RRP9,RPL12,RPL13A,EXOSC5,RRP7A,DDX47
R-HSA-427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	0.99129228959737	-0.00874584404538973	76	60	0.00664157626743414	9034	10285	1108,8344,723790,8364,3020,57459,8352,54815,8359,10919,8335,9219,1107,128312,8362,8349,57504,3065,55766,3021,3012,53615,3066,8354,8348,121504,8366,3017,8368,3015,8346,8334,8350,94239,8370,8341,2074,8365,126961,3018,8367,8361,8347,8353,8345,8357,8339,5928,8355,8970,8343,7270,8360,8363,8340,3013,8968,11335,653604,8358	CHD4,H2BC6,H2AC19,H4C3,H3-3A,GATAD2B,H3C3,GATAD2A,H4C1,EHMT2,H2AC4,MTA2,CHD3,H2BC26,H4C12,H2BC21,MTA3,HDAC1,H2AJ,H3-3B,H2AC8,MBD3,HDAC2,H3C11,H2BC17,H4C16,H4C2,H2BC5,H4C13,H2AZ1,H2BC10,H2AC6,H3C1,H2AZ2,H4C14,H2BC15,ERCC6,H4C8,H3C14,H2BC3,H4C5,H4C6,H2BC4,H3C6,H2BC9,H3C10,H2BC8,RBBP4,H3C8,H2BC11,H2BC7,TTF1,H4C4,H4C11,H2BC13,H2AC7,H3C7,CBX3,H3C13,H3C2
R-HSA-203927	MicroRNA (miRNA) biogenesis	0.99245997467669	-0.0075685950156508	25	18	0.00199247288023024	9034	10285	26523,5439,5430,5432,29102,5901,5440,27161,5433,5434,192669,192670,5441,54487,57510,8575,23405,5431	AGO1,POLR2J,POLR2A,POLR2C,DROSHA,RAN,POLR2K,AGO2,POLR2D,POLR2E,AGO3,AGO4,POLR2L,DGCR8,XPO5,PRKRA,DICER1,POLR2B
R-HSA-73728	RNA Polymerase I Promoter Opening	0.992618252540452	-0.00740912738165356	63	49	0.00542395395173788	9034	10285	8367,8365,3018,126961,94239,8370,8341,8350,8932,8353,8345,8347,8361,121504,8366,5595,8348,8334,8346,8368,3015,3017,3013,8358,8968,653604,8360,8355,8343,8970,8339,8357,8340,8363,8335,8352,8359,7343,723790,8344,3020,8364,3021,55766,8354,3012,8362,128312,8349	H4C5,H4C8,H2BC3,H3C14,H2AZ2,H4C14,H2BC15,H3C1,MBD2,H3C6,H2BC9,H2BC4,H4C6,H4C16,H4C2,MAPK3,H2BC17,H2AC6,H2BC10,H4C13,H2AZ1,H2BC5,H2AC7,H3C2,H3C7,H3C13,H4C4,H3C8,H2BC7,H2BC11,H2BC8,H3C10,H2BC13,H4C11,H2AC4,H3C3,H4C1,UBTF,H2AC19,H2BC6,H3-3A,H4C3,H3-3B,H2AJ,H3C11,H2AC8,H4C12,H2BC26,H2BC21
R-HSA-72689	Formation of a pool of free 40S subunits	0.992935082915848	-0.00708999178108525	105	84	0.00929820677440779	9034	10285	6206,3646,6217,6229,6154,6194,4736,6129,6122,6208,6189,6207,6205,6230,6133,8669,8662,6142,6130,27335,6233,6169,6201,6235,9045,10480,6124,6135,6152,6137,6159,6231,7311,6224,6210,6164,6138,200916,23521,6144,8664,6136,6123,140801,6176,51121,11224,6156,6223,116832,51386,6204,6232,9349,6155,6143,6157,6139,6175,6160,728689,6209,6202,6161,6188,8665,8667,6128,3921,8661,6167,6165,6228,6168,6181,6227,8666,6146,51065,6125,8668,6234,6166,25873	RPS12,EIF3E,RPS16,RPS24,RPL26,RPS6,RPL10A,RPL7,RPL3,RPS14,RPS3A,RPS13,RPS11,RPS25,RPL9,EIF3J,EIF3B,RPL18A,RPL7A,EIF3K,RPS27A,RPL38,RPS7,RPS29,RPL14,EIF3M,RPL4,RPL11,RPL24,RPL13,RPL29,RPS26,UBA52,RPS20,RPS15A,RPL34,RPL15,RPL22L1,RPL13A,RPL21,EIF3D,RPL12,RPL3L,RPL10L,RPLP1,RPL26L1,RPL35,RPL30,RPS19,RPL39L,EIF3L,RPS10,RPS27,RPL23,RPL27,RPL19,RPL27A,RPL17,RPLP0,RPL31,EIF3CL,RPS15,RPS8,RPL32,RPS3,EIF3F,EIF3H,RPL6,RPSA,EIF3A,RPL37,RPL35A,RPS23,RPL37A,RPLP2,RPS21,EIF3G,RPL22,RPS27L,RPL5,EIF3I,RPS28,RPL36AL,RPL36
R-HSA-504046	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.993363082668359	-0.00665903960426644	149	121	0.0133938454726588	9034	10285	3012,3066,221830,7019,55766,10302,3021,2971,4331,3065,9329,9015,4781,9533,8352,10919,2968,8335,8364,11128,57459,6619,1108,723790,171568,84265,64216,27297,11335,5434,8850,4784,8363,8340,8357,6618,5441,8355,8970,10849,8361,5451,8347,8345,4774,8350,94239,3017,8368,3015,8346,10623,9328,1022,5595,404672,2975,55718,112495,53615,8354,10622,9330,7978,2976,8349,51728,57504,128312,2068,8362,7343,6741,51082,9219,5442,1107,54815,54700,8359,284119,3020,2965,2967,2071,8344,9014,8968,653604,6617,8358,902,25885,7702,3013,64425,8339,5928,55290,79101,8343,7270,55703,8360,84172,4782,5440,8353,8932,2074,8341,8370,8365,661,3018,126961,8367,8334,8348,121504,8366	H2AC8,HDAC2,POLR1F,TFAM,H2AJ,SNAPC5,H3-3B,GTF3A,MNAT1,HDAC1,GTF3C4,TAF1A,NFIB,POLR1C,H3C3,EHMT2,GTF2H4,H2AC4,H4C3,POLR3A,GATAD2B,SNAPC3,CHD4,H2AC19,POLR3H,POLR3GL,TFB2M,CRCP,CBX3,POLR2E,KAT2B,NFIX,H4C11,H2BC13,H3C10,SNAPC2,POLR2L,H3C8,H2BC11,POLR1G,H4C6,POU2F1,H2BC4,H2BC9,NFIA,H3C1,H2AZ2,H2BC5,H4C13,H2AZ1,H2BC10,POLR3C,GTF3C5,CDK7,MAPK3,GTF2H5,GTF3C1,POLR3E,GTF3C6,MBD3,H3C11,POLR3G,GTF3C3,MTERF1,GTF3C2,H2BC21,POLR3K,MTA3,H2BC26,ERCC2,H4C12,UBTF,SSB,POLR1D,MTA2,POLRMT,CHD3,GATAD2A,RRN3,H4C1,CAVIN1,H3-3A,GTF2H1,GTF2H3,ERCC3,H2BC6,TAF1B,H3C7,H3C13,SNAPC1,H3C2,CCNH,POLR1A,ZNF143,H2AC7,POLR1E,H2BC8,RBBP4,BRF2,TAF1D,H2BC7,TTF1,POLR3B,H4C4,POLR1B,NFIC,POLR2K,H3C6,MBD2,ERCC6,H2BC15,H4C14,H4C8,POLR3D,H2BC3,H3C14,H4C5,H2AC6,H2BC17,H4C16,H4C2
R-HSA-2299718	Condensation of Prophase Chromosomes	0.993396523694602	-0.00662537571645752	74	58	0.006420190391853	9034	10285	8290,8335,8352,8359,983,3020,8364,8344,23310,6418,10592,723790,3012,8354,55766,79648,3021,891,387893,8349,128312,8362,8361,8353,8345,8347,94239,8370,8341,5347,8350,8367,8365,126961,3018,8368,3015,3017,8334,8346,8348,121504,8366,8968,653604,5925,8358,3013,10051,8363,8340,54892,8355,8970,8343,8357,8339,8360	H3-4,H2AC4,H3C3,H4C1,CDK1,H3-3A,H4C3,H2BC6,NCAPD3,SET,SMC2,H2AC19,H2AC8,H3C11,H2AJ,MCPH1,H3-3B,CCNB1,KMT5A,H2BC21,H2BC26,H4C12,H4C6,H3C6,H2BC9,H2BC4,H2AZ2,H4C14,H2BC15,PLK1,H3C1,H4C5,H4C8,H3C14,H2BC3,H4C13,H2AZ1,H2BC5,H2AC6,H2BC10,H2BC17,H4C16,H4C2,H3C7,H3C13,RB1,H3C2,H2AC7,SMC4,H4C11,H2BC13,NCAPG2,H3C8,H2BC11,H2BC7,H3C10,H2BC8,H4C4
R-HSA-72172	mRNA Splicing	0.993424084261346	-0.00659763232922286	195	160	0.017710870046491	9034	10285	10907,10189,5439,3191,1479,23524,7536,81608,7307,53981,26121,10465,6635,988,6637,407043,4809,10594,3183,10949,10262,1660,3178,100616394,23658,23020,51593,6636,9343,22826,220988,3181,1665,6428,23398,5434,54883,5441,10291,6434,11338,10081,11193,55110,5725,56259,57703,83443,24144,57819,6429,22794,23451,5433,6626,79869,27258,51692,79622,10992,9092,2521,23350,6625,10569,9416,55339,6627,55599,2963,85437,6431,10283,10898,9295,3312,10946,51639,51362,3184,6936,51645,5431,84950,9410,10450,6631,8896,5432,4116,5093,51729,51585,5440,10286,51691,10285,6432,10250,24148,11100,11157,8189,1994,8106,10772,25949,10421,6426,10181,10523,23517,5356,3187,6629,4904,3185,2962,6633,10236,55696,9129,10978,3190,11066,22827,11017,57794,55954,5546,9716,154007,5430,6628,8449,1993,55660,100616459,55749,25804,51690,84991,10713,84844,6430,9128,51503,22938,57461,11325,5094,4670,4686,10914,9879,8683,23283,3192,22916,9775	TXNL4A,ALYREF,POLR2J,HNRNPL,CSTF3,SRRM2,SF1,FIP1L1,U2AF1,CPSF2,PRPF31,PPIH,SNRPE,CDC5L,SNRPG,MIR7-1,SNU13,PRPF8,HNRNPC,HNRNPA0,SF3B4,DHX9,HNRNPA1,MIR4444-1,LSM5,SNRNP200,SRRT,SNRPF,EFTUD2,DNAJC8,HNRNPA3,HNRNPA2B1,DHX15,SRSF3,PPWD1,POLR2E,CWC25,POLR2L,SF3A1,TRA2B,U2AF2,PDCD7,WBP4,MAGOHB,PTBP1,CTNNBL1,CWC22,SF3B5,TFIP11,LSM2,SRSF4,CASC3,SF3B1,POLR2D,SNRPA,CPSF7,LSM3,CPSF3,SNRNP25,SF3B2,SART1,FUS,U2SURP,SNRNP70,SLU7,DDX23,WDR33,SNRPA1,RNPC3,GTF2F2,ZCRB1,SRSF6,CWC27,CPSF4,SRSF11,HSPA8,SF3A3,SF3B6,CDC40,HNRNPD,GCFC2,PPIL1,POLR2B,PRPF38A,SNRNP40,PPIE,SNRPC,BUD31,POLR2C,MAGOH,PCBP1,WBP11,PCF11,POLR2K,BCAS2,LSM8,SMNDC1,SRSF7,SRRM1,PRPF6,HNRNPUL1,LSM6,SYMPK,ELAVL1,PABPN1,SRSF10,SYF2,CD2BP2,SRSF1,RBM5,CHERP,MTREX,PLRG1,HNRNPH1,SNRPB2,YBX1,HNRNPF,GTF2F1,SNRPD2,HNRNPR,RBM22,PRPF3,CLP1,HNRNPK,SNRNP35,PUF60,SNRNP27,SUGP1,ZMAT5,PRCC,AQR,SNRNP48,POLR2A,SNRPB,DHX16,ELAVL2,PRPF40A,MIR4745,CCAR1,LSM4,LSM7,RBM17,USP39,PHF5A,SRSF5,PRPF4,CWC15,SNW1,ISY1,DDX42,PCBP2,HNRNPM,NCBP1,PAPOLA,DDX46,SRSF9,CSTF2T,HNRNPU,NCBP2,EIF4A3
R-HSA-156902	Peptide chain elongation	0.993465196318995	-0.00655624898888683	92	73	0.00808058445871153	9034	10285	6123,140801,116832,6223,6204,6176,6156,11224,51121,9349,6232,6160,6143,6155,6157,6175,6139,6128,6202,6209,6188,6161,6167,6228,6165,3921,6146,6181,6168,6227,6166,6234,25873,6125,51065,6154,4736,6194,6217,6206,6229,6208,6189,6122,6129,6133,6142,6207,6230,6205,1915,6169,6233,6201,6130,6124,6235,9045,6231,6224,7311,1938,6135,6137,6159,6152,200916,6138,6210,6164,23521,6144,6136	RPL3L,RPL10L,RPL39L,RPS19,RPS10,RPLP1,RPL30,RPL35,RPL26L1,RPL23,RPS27,RPL31,RPL19,RPL27,RPL27A,RPLP0,RPL17,RPL6,RPS8,RPS15,RPS3,RPL32,RPL37,RPS23,RPL35A,RPSA,RPL22,RPLP2,RPL37A,RPS21,RPL36AL,RPS28,RPL36,RPL5,RPS27L,RPL26,RPL10A,RPS6,RPS16,RPS12,RPS24,RPS14,RPS3A,RPL3,RPL7,RPL9,RPL18A,RPS13,RPS25,RPS11,EEF1A1,RPL38,RPS27A,RPS7,RPL7A,RPL4,RPS29,RPL14,RPS26,RPS20,UBA52,EEF2,RPL11,RPL13,RPL29,RPL24,RPL22L1,RPL15,RPS15A,RPL34,RPL13A,RPL21,RPL12
R-HSA-192823	Viral mRNA Translation	0.993465196318995	-0.00655624898888683	92	73	0.00808058445871153	9034	10285	6124,9045,6235,6231,6224,7311,6135,6137,6159,6152,6138,200916,6210,6164,23521,6144,6136,6154,4736,6194,6217,6206,5611,6229,6208,6189,6122,6129,6133,6142,6207,6205,6230,6169,6233,6201,6130,6128,6202,6209,6188,2926,6161,6167,6228,6165,3921,6146,6181,6168,6227,6166,6234,25873,6125,51065,6123,140801,116832,6223,6204,6176,6156,51121,11224,9349,6232,6160,6143,6155,6175,6157,6139	RPL4,RPL14,RPS29,RPS26,RPS20,UBA52,RPL11,RPL13,RPL29,RPL24,RPL15,RPL22L1,RPS15A,RPL34,RPL13A,RPL21,RPL12,RPL26,RPL10A,RPS6,RPS16,RPS12,DNAJC3,RPS24,RPS14,RPS3A,RPL3,RPL7,RPL9,RPL18A,RPS13,RPS11,RPS25,RPL38,RPS27A,RPS7,RPL7A,RPL6,RPS8,RPS15,RPS3,GRSF1,RPL32,RPL37,RPS23,RPL35A,RPSA,RPL22,RPLP2,RPL37A,RPS21,RPL36AL,RPS28,RPL36,RPL5,RPS27L,RPL3L,RPL10L,RPL39L,RPS19,RPS10,RPLP1,RPL30,RPL26L1,RPL35,RPL23,RPS27,RPL31,RPL19,RPL27,RPLP0,RPL27A,RPL17
R-HSA-8848584	Wax biosynthesis	0.993470923920091	-0.00655048372946265	4	2	0.000221385875581138	9034	10285	84188,55711	FAR1,FAR2
R-HSA-6803544	Ion influx/efflux at host-pathogen interface	0.993470923920091	-0.00655048372946265	4	2	0.000221385875581138	9034	10285	6556,475	SLC11A1,ATOX1
R-HSA-72163	mRNA Splicing - Major Pathway	0.994133410915219	-0.00588386511925899	187	153	0.0169360194819571	9034	10285	51690,25804,55749,6628,8449,5430,100616459,55660,1993,9128,6430,84844,22938,51503,10713,84991,4670,10914,4686,5094,11325,57461,22916,3192,9775,23283,8683,9879,51729,5440,51585,8896,5432,6631,10450,5093,4116,6432,10285,24148,11100,10250,10286,51691,23517,10523,6426,10181,10421,25949,3185,2962,4904,6629,3187,5356,11157,8189,8106,10772,1994,3190,10978,9716,5546,57794,11017,22827,10236,6633,9129,55696,6429,22794,57819,79869,6626,5433,23451,5725,24144,83443,57703,56259,2521,23350,9416,6627,55339,10569,6625,27258,9092,10992,51692,9295,3312,10898,2963,10283,6431,51645,9410,84950,5431,3184,51362,51639,10946,6936,10465,26121,53981,7307,6637,988,6635,5439,10907,10189,81608,7536,23524,3191,1479,23020,23658,100616394,6636,51593,3183,10949,10594,4809,407043,3178,1660,10262,54883,5434,23398,3181,22826,220988,9343,6428,1665,11193,55110,5441,11338,6434,10291	LSM7,LSM4,CCAR1,SNRPB,DHX16,POLR2A,MIR4745,PRPF40A,ELAVL2,PRPF4,SRSF5,PHF5A,SNW1,CWC15,USP39,RBM17,HNRNPM,PAPOLA,NCBP1,PCBP2,DDX42,ISY1,NCBP2,HNRNPU,EIF4A3,CSTF2T,SRSF9,DDX46,WBP11,POLR2K,PCF11,BUD31,POLR2C,SNRPC,PPIE,PCBP1,MAGOH,SRSF7,SMNDC1,PRPF6,HNRNPUL1,SRRM1,BCAS2,LSM8,MTREX,CHERP,SRSF1,RBM5,CD2BP2,SYF2,HNRNPF,GTF2F1,YBX1,SNRPB2,HNRNPH1,PLRG1,LSM6,SYMPK,PABPN1,SRSF10,ELAVL1,HNRNPK,CLP1,AQR,PRCC,SUGP1,SNRNP27,PUF60,HNRNPR,SNRPD2,PRPF3,RBM22,SRSF4,CASC3,LSM2,CPSF7,SNRPA,POLR2D,SF3B1,PTBP1,TFIP11,SF3B5,CWC22,CTNNBL1,FUS,U2SURP,DDX23,SNRPA1,WDR33,SLU7,SNRNP70,LSM3,SART1,SF3B2,CPSF3,SRSF11,HSPA8,CPSF4,GTF2F2,CWC27,SRSF6,PPIL1,SNRNP40,PRPF38A,POLR2B,HNRNPD,CDC40,SF3B6,SF3A3,GCFC2,PPIH,PRPF31,CPSF2,U2AF1,SNRPG,CDC5L,SNRPE,POLR2J,TXNL4A,ALYREF,FIP1L1,SF1,SRRM2,HNRNPL,CSTF3,SNRNP200,LSM5,MIR4444-1,SNRPF,SRRT,HNRNPC,HNRNPA0,PRPF8,SNU13,MIR7-1,HNRNPA1,DHX9,SF3B4,CWC25,POLR2E,PPWD1,HNRNPA2B1,DNAJC8,HNRNPA3,EFTUD2,SRSF3,DHX15,WBP4,MAGOHB,POLR2L,U2AF2,TRA2B,SF3A1
R-HSA-3214858	RMTs methylate histone arginines	0.99421854926513	-0.00579822801710855	79	62	0.00686296214301528	9034	10285	6604,55766,8354,1019,3012,10498,8362,221613,86,10419,6599,8969,57492,8335,3717,8352,8359,6602,196528,723790,8364,55193,3013,595,51412,1788,54496,8358,92815,8968,653604,8289,8360,8355,6601,55170,8357,8332,6605,8363,8367,8365,126961,94239,6603,8370,8350,8353,10196,6597,8361,55352,79084,6595,121504,8366,6598,11091,3276,8334,8368,3015	SMARCD3,H2AJ,H3C11,CDK4,H2AC8,CARM1,H4C12,H2AC1,ACTL6A,PRMT5,SMARCC1,H2AC11,ARID1B,H2AC4,JAK2,H3C3,H4C1,SMARCD1,ARID2,H2AC19,H4C3,PBRM1,H2AC7,CCND1,ACTL6B,DNMT3A,PRMT7,H3C2,H2AC25,H3C7,H3C13,ARID1A,H4C4,H3C8,SMARCC2,PRMT6,H3C10,H2AC16,SMARCE1,H4C11,H4C5,H4C8,H3C14,H2AZ2,SMARCD2,H4C14,H3C1,H3C6,PRMT3,SMARCA4,H4C6,COPRS,WDR77,SMARCA2,H4C16,H4C2,SMARCB1,WDR5,PRMT1,H2AC6,H4C13,H2AZ1
R-HSA-1912399	Pre-NOTCH Processing in the Endoplasmic Reticulum	0.994375498908039	-0.00564037815994023	7	4	0.000442771751162276	9034	10285	4854,4853,23509,4855	NOTCH3,NOTCH2,POFUT1,NOTCH4
R-HSA-5625886	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	0.994412685163583	-0.00560298226645473	67	52	0.00575603276510959	9034	10285	8363,8340,3817,8357,8339,8355,8970,8343,5585,8360,8968,653604,8358,23081,3013,3017,8368,3015,8346,23028,8334,8348,121504,8366,8361,8347,8353,8345,8350,94239,8370,10499,8341,8365,126961,3018,8367,8349,128312,354,8362,3012,8354,55766,3021,8364,3020,8344,723790,8352,8359,8335	H4C11,H2BC13,KLK2,H3C10,H2BC8,H3C8,H2BC11,H2BC7,PKN1,H4C4,H3C7,H3C13,H3C2,KDM4C,H2AC7,H2BC5,H4C13,H2AZ1,H2BC10,KDM1A,H2AC6,H2BC17,H4C16,H4C2,H4C6,H2BC4,H3C6,H2BC9,H3C1,H2AZ2,H4C14,NCOA2,H2BC15,H4C8,H3C14,H2BC3,H4C5,H2BC21,H2BC26,KLK3,H4C12,H2AC8,H3C11,H2AJ,H3-3B,H4C3,H3-3A,H2BC6,H2AC19,H3C3,H4C1,H2AC4
R-HSA-163841	Gamma carboxylation, hypusine formation and arylsulfatase activation	0.99455386836322	-0.00546101587730236	39	29	0.0032100951959265	9034	10285	340075,120526,1801,83475,79672,2147,285362,23463,153642,2159,632,51611,1725,89978,411,79642,56648,5045,5627,2677,1984,22901,8858,1938,285381,64122,2155,5624,1802	ARSI,DNAJC24,DPH1,DOHH,FN3KRP,F2,SUMF1,ICMT,ARSK,F10,BGLAP,DPH5,DHPS,DPH6,ARSB,ARSJ,EIF5A2,FURIN,PROS1,GGCX,EIF5A,ARSG,PROZ,EEF2,DPH3,FN3K,F7,PROC,DPH2
R-HSA-72702	Ribosomal scanning and start codon recognition	0.994622007694422	-0.00539250576510068	61	47	0.00520256807615674	9034	10285	6231,6224,10480,6235,8664,6210,6208,6189,6194,6217,6206,3646,6229,6233,6201,1974,27335,8662,8669,6207,6205,6230,6228,8661,1981,3921,8665,8667,6202,6209,6188,6234,51065,8668,8666,1965,8894,6227,51386,6223,6204,1977,1975,728689,1983,7458,6232	RPS26,RPS20,EIF3M,RPS29,EIF3D,RPS15A,RPS14,RPS3A,RPS6,RPS16,RPS12,EIF3E,RPS24,RPS27A,RPS7,EIF4A2,EIF3K,EIF3B,EIF3J,RPS13,RPS11,RPS25,RPS23,EIF3A,EIF4G1,RPSA,EIF3F,EIF3H,RPS8,RPS15,RPS3,RPS28,RPS27L,EIF3I,EIF3G,EIF2S1,EIF2S2,RPS21,EIF3L,RPS19,RPS10,EIF4E,EIF4B,EIF3CL,EIF5,EIF4H,RPS27
R-HSA-156842	Eukaryotic Translation Elongation	0.994989407800859	-0.00502318730647932	96	76	0.00841266327208324	9034	10285	23521,6144,6136,6138,200916,6210,6164,1937,6231,7311,6224,1938,6135,6152,6159,6137,6124,9045,6235,1936,6233,6169,6201,6130,6133,6142,1917,6207,1915,6230,6205,6208,6189,6129,6122,6154,6194,4736,6206,6217,6229,6234,6166,25873,51065,6125,6146,6168,6181,6227,6167,6165,6228,3921,6128,6209,6202,6161,6188,6160,6155,6143,6157,6175,6139,9349,6232,6223,116832,6204,6176,51121,11224,6156,6123,140801	RPL13A,RPL21,RPL12,RPL15,RPL22L1,RPS15A,RPL34,EEF1G,RPS26,UBA52,RPS20,EEF2,RPL11,RPL24,RPL29,RPL13,RPL4,RPL14,RPS29,EEF1D,RPS27A,RPL38,RPS7,RPL7A,RPL9,RPL18A,EEF1A2,RPS13,EEF1A1,RPS25,RPS11,RPS14,RPS3A,RPL7,RPL3,RPL26,RPS6,RPL10A,RPS12,RPS16,RPS24,RPS28,RPL36AL,RPL36,RPS27L,RPL5,RPL22,RPL37A,RPLP2,RPS21,RPL37,RPL35A,RPS23,RPSA,RPL6,RPS15,RPS8,RPL32,RPS3,RPL31,RPL27,RPL19,RPL27A,RPLP0,RPL17,RPL23,RPS27,RPS19,RPL39L,RPS10,RPLP1,RPL26L1,RPL35,RPL30,RPL3L,RPL10L
R-HSA-72764	Eukaryotic Translation Termination	0.994989407800859	-0.00502318730647932	96	76	0.00841266327208324	9034	10285	6208,6189,6122,6129,6154,4736,6194,6217,6206,6229,6169,6233,29104,6201,6130,6133,6142,327,6207,6205,6230,6231,6224,7311,6135,6159,6137,6152,6124,9045,6235,2935,6144,23521,6136,200916,6138,6210,6164,116832,6223,6204,6176,6156,51121,11224,6123,140801,6160,51504,6143,6155,6139,6157,6175,9349,6232,6167,6228,6165,3921,2107,6128,6202,6209,6188,6161,6166,6234,25873,6125,51065,6146,6181,6168,6227	RPS14,RPS3A,RPL3,RPL7,RPL26,RPL10A,RPS6,RPS16,RPS12,RPS24,RPL38,RPS27A,N6AMT1,RPS7,RPL7A,RPL9,RPL18A,APEH,RPS13,RPS11,RPS25,RPS26,RPS20,UBA52,RPL11,RPL29,RPL13,RPL24,RPL4,RPL14,RPS29,GSPT1,RPL21,RPL13A,RPL12,RPL22L1,RPL15,RPS15A,RPL34,RPL39L,RPS19,RPS10,RPLP1,RPL30,RPL26L1,RPL35,RPL3L,RPL10L,RPL31,TRMT112,RPL19,RPL27,RPL17,RPL27A,RPLP0,RPL23,RPS27,RPL37,RPS23,RPL35A,RPSA,ETF1,RPL6,RPS8,RPS15,RPS3,RPL32,RPL36AL,RPS28,RPL36,RPL5,RPS27L,RPL22,RPLP2,RPL37A,RPS21
R-HSA-427413	NoRC negatively regulates rRNA expression	0.995703895846154	-0.00430535892511511	107	85	0.00940889971219836	9034	10285	3013,25885,1786,8358,902,5434,8968,653604,9014,84172,8360,10849,7270,64426,8355,8970,8819,8343,79101,8339,8357,5441,64425,8340,11176,8363,8467,79685,8367,8365,3018,126961,94239,8341,8370,8350,8932,5440,8353,8345,8347,8361,121504,8366,8348,404672,8334,1022,8346,8368,3015,23309,3017,3021,79595,55766,8354,3066,221830,3012,8362,2068,9015,128312,3065,8349,4331,2968,25942,8335,9533,8352,8359,51742,51082,7343,723790,8344,2071,10284,2967,29115,2965,3020,8364	H2AC7,POLR1A,DNMT1,H3C2,CCNH,POLR2E,H3C7,H3C13,TAF1B,POLR1B,H4C4,POLR1G,TTF1,SUDS3,H3C8,H2BC11,SAP30,H2BC7,TAF1D,H2BC8,H3C10,POLR2L,POLR1E,H2BC13,BAZ2A,H4C11,SMARCA5,SAP30L,H4C5,H4C8,H2BC3,H3C14,H2AZ2,H2BC15,H4C14,H3C1,MBD2,POLR2K,H3C6,H2BC9,H2BC4,H4C6,H4C16,H4C2,H2BC17,GTF2H5,H2AC6,CDK7,H2BC10,H4C13,H2AZ1,SIN3B,H2BC5,H3-3B,SAP130,H2AJ,H3C11,HDAC2,POLR1F,H2AC8,H4C12,ERCC2,TAF1A,H2BC26,HDAC1,H2BC21,MNAT1,GTF2H4,SIN3A,H2AC4,POLR1C,H3C3,H4C1,ARID4B,POLR1D,UBTF,H2AC19,H2BC6,ERCC3,SAP18,GTF2H3,SAP30BP,GTF2H1,H3-3A,H4C3
R-HSA-5334118	DNA methylation	0.995930721219862	-0.0040775808249101	65	50	0.00553464688952845	9034	10285	29947,8335,8352,8359,3020,8364,723790,8344,8354,3012,3021,55766,8349,8362,128312,8353,8345,8347,8361,8367,8365,3018,126961,94239,8370,8341,8350,8334,8346,8368,3015,3017,121504,8366,8348,1788,8358,8968,653604,3013,1786,29128,8340,8363,8360,8355,8343,8970,8357,8339	DNMT3L,H2AC4,H3C3,H4C1,H3-3A,H4C3,H2AC19,H2BC6,H3C11,H2AC8,H3-3B,H2AJ,H2BC21,H4C12,H2BC26,H3C6,H2BC9,H2BC4,H4C6,H4C5,H4C8,H2BC3,H3C14,H2AZ2,H4C14,H2BC15,H3C1,H2AC6,H2BC10,H4C13,H2AZ1,H2BC5,H4C16,H4C2,H2BC17,DNMT3A,H3C2,H3C7,H3C13,H2AC7,DNMT1,UHRF1,H2BC13,H4C11,H4C4,H3C8,H2BC7,H2BC11,H3C10,H2BC8
R-HSA-72613	Eukaryotic Translation Initiation	0.995999656034488	-0.00400836674449786	125	100	0.0110692937790569	9034	10285	6136,23521,6164,6210,6224,7311,6231,6137,6152,6135,8891,10480,6201,6169,6233,6130,8662,6142,8893,6189,6208,6122,4736,6194,9669,6229,6217,3646,6234,6125,51065,8894,6146,1965,8666,1967,6181,6168,6228,8667,8665,6188,6161,6209,6157,6155,9349,6204,116832,6223,6156,51121,11224,26986,1975,1977,6144,8664,6138,200916,6159,6124,6235,9045,1974,27335,8890,8669,6133,6230,6205,6207,6129,6154,6206,25873,6166,8668,6227,6165,6167,1981,8661,3921,6128,6202,728689,6160,1978,6175,6139,1983,6143,8892,7458,6232,51386,6176,140801,6123	RPL12,RPL13A,RPL34,RPS15A,RPS20,UBA52,RPS26,RPL13,RPL24,RPL11,EIF2B3,EIF3M,RPS7,RPL38,RPS27A,RPL7A,EIF3B,RPL18A,EIF2B5,RPS3A,RPS14,RPL3,RPL10A,RPS6,EIF5B,RPS24,RPS16,EIF3E,RPS28,RPL5,RPS27L,EIF2S2,RPL22,EIF2S1,EIF3G,EIF2B1,RPLP2,RPL37A,RPS23,EIF3H,EIF3F,RPS3,RPL32,RPS15,RPL27A,RPL27,RPL23,RPS10,RPL39L,RPS19,RPL30,RPL26L1,RPL35,PABPC1,EIF4B,EIF4E,RPL21,EIF3D,RPL15,RPL22L1,RPL29,RPL4,RPS29,RPL14,EIF4A2,EIF3K,EIF2B4,EIF3J,RPL9,RPS25,RPS11,RPS13,RPL7,RPL26,RPS12,RPL36,RPL36AL,EIF3I,RPS21,RPL35A,RPL37,EIF4G1,EIF3A,RPSA,RPL6,RPS8,EIF3CL,RPL31,EIF4EBP1,RPLP0,RPL17,EIF5,RPL19,EIF2B2,EIF4H,RPS27,EIF3L,RPLP1,RPL10L,RPL3L
R-HSA-72737	Cap-dependent Translation Initiation	0.995999656034488	-0.00400836674449786	125	100	0.0110692937790569	9034	10285	6228,8665,8667,6209,6161,6188,6234,51065,6125,1967,8666,6146,8894,1965,6168,6181,6223,116832,6204,51121,11224,6156,26986,1977,1975,6155,6157,9349,7311,6231,6224,6135,6152,6137,10480,8891,23521,6136,6210,6164,6208,6189,6122,9669,6194,4736,3646,6217,6229,6233,6169,6201,6130,8893,6142,8662,6167,6165,3921,8661,1981,6128,6202,6166,25873,8668,6227,51386,6176,6123,140801,1978,6160,728689,8892,1983,6143,6175,6139,6232,7458,6159,6124,9045,6235,6144,8664,200916,6138,6129,6154,6206,1974,8890,27335,6133,8669,6207,6230,6205	RPS23,EIF3F,EIF3H,RPS15,RPL32,RPS3,RPS28,RPS27L,RPL5,EIF2B1,EIF3G,RPL22,EIF2S2,EIF2S1,RPL37A,RPLP2,RPS19,RPL39L,RPS10,RPL26L1,RPL35,RPL30,PABPC1,EIF4E,EIF4B,RPL27,RPL27A,RPL23,UBA52,RPS26,RPS20,RPL11,RPL24,RPL13,EIF3M,EIF2B3,RPL13A,RPL12,RPS15A,RPL34,RPS14,RPS3A,RPL3,EIF5B,RPS6,RPL10A,EIF3E,RPS16,RPS24,RPS27A,RPL38,RPS7,RPL7A,EIF2B5,RPL18A,EIF3B,RPL37,RPL35A,RPSA,EIF3A,EIF4G1,RPL6,RPS8,RPL36AL,RPL36,EIF3I,RPS21,EIF3L,RPLP1,RPL3L,RPL10L,EIF4EBP1,RPL31,EIF3CL,EIF2B2,EIF5,RPL19,RPLP0,RPL17,RPS27,EIF4H,RPL29,RPL4,RPL14,RPS29,RPL21,EIF3D,RPL22L1,RPL15,RPL7,RPL26,RPS12,EIF4A2,EIF2B4,EIF3K,RPL9,EIF3J,RPS13,RPS25,RPS11
R-HSA-3214815	HDACs deacetylate histones	0.996136228400013	-0.00387125524843404	94	74	0.0081912773965021	9034	10285	9611,2874,3013,8841,8358,92815,8968,653604,64426,8360,8339,8357,5928,8332,8355,8819,8970,8343,8340,5926,8363,440689,79685,25855,8365,126961,3018,8367,8350,79718,8341,8370,8347,8353,8345,8361,121504,8366,8348,5978,8346,23028,8334,83933,3017,8368,53615,3066,8354,3012,23186,8362,221613,128312,8349,57504,3065,51317,10362,8969,54815,8352,8359,8335,9219,51742,1107,723790,1108,8344,57459,10284,8364,9612	NCOR1,GPS2,H2AC7,HDAC3,H3C2,H2AC25,H3C7,H3C13,SUDS3,H4C4,H2BC8,H3C10,RBBP4,H2AC16,H3C8,SAP30,H2BC11,H2BC7,H2BC13,ARID4A,H4C11,H2BC18,SAP30L,BRMS1,H4C8,H3C14,H2BC3,H4C5,H3C1,TBL1XR1,H2BC15,H4C14,H2BC4,H3C6,H2BC9,H4C6,H4C16,H4C2,H2BC17,REST,H2BC10,KDM1A,H2AC6,HDAC10,H2BC5,H4C13,MBD3,HDAC2,H3C11,H2AC8,RCOR1,H4C12,H2AC1,H2BC26,H2BC21,MTA3,HDAC1,PHF21A,HMG20B,H2AC11,GATAD2A,H3C3,H4C1,H2AC4,MTA2,ARID4B,CHD3,H2AC19,CHD4,H2BC6,GATAD2B,SAP18,H4C3,NCOR2
R-HSA-912446	Meiotic recombination	0.996141968834769	-0.00386549256452317	88	69	0.00763781270754926	9034	10285	8341,8370,94239,8350,8367,126961,3018,8365,27030,8361,8345,8353,8347,8348,8366,121504,3015,8368,56154,3017,8334,7156,1017,8346,3013,5888,653604,8968,6118,11144,8358,8970,8343,84057,8355,6117,8339,8357,8360,4361,10111,8363,8340,4292,6119,8335,4683,8359,8352,5889,8290,8344,675,4438,723790,472,3020,8364,55766,641,56979,3021,3012,8354,1019,672,128312,8362,8349	H2BC15,H4C14,H2AZ2,H3C1,H4C5,H3C14,H2BC3,H4C8,MLH3,H4C6,H2BC9,H3C6,H2BC4,H2BC17,H4C2,H4C16,H2AZ1,H4C13,TEX15,H2BC5,H2AC6,TOP3A,CDK2,H2BC10,H2AC7,RAD51,H3C13,H3C7,RPA2,DMC1,H3C2,H2BC11,H2BC7,MND1,H3C8,RPA1,H2BC8,H3C10,H4C4,MRE11,RAD50,H4C11,H2BC13,MLH1,RPA3,H2AC4,NBN,H4C1,H3C3,RAD51C,H3-4,H2BC6,BRCA2,MSH4,H2AC19,ATM,H3-3A,H4C3,H2AJ,BLM,PRDM9,H3-3B,H2AC8,H3C11,CDK4,BRCA1,H2BC26,H4C12,H2BC21
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	0.996625178641929	-0.00338052891260625	99	78	0.00863404914766438	9034	10285	6138,200916,6210,6164,6144,23521,6136,5976,6124,6235,9045,2935,6231,6224,7311,6135,6152,6159,6137,6133,6142,6207,6230,6205,6233,6169,6201,6130,6154,6194,4736,6206,6217,6229,6208,6189,6129,6122,6146,6168,6181,6227,6234,6166,25873,51065,6125,2107,6128,6209,6202,6161,6188,6167,6228,6165,3921,1981,9349,4686,6232,6160,6155,6143,6139,6157,6175,26986,6123,140801,22916,6223,116832,6204,6176,11224,51121,6156	RPL15,RPL22L1,RPS15A,RPL34,RPL21,RPL13A,RPL12,UPF1,RPL4,RPS29,RPL14,GSPT1,RPS26,RPS20,UBA52,RPL11,RPL24,RPL29,RPL13,RPL9,RPL18A,RPS13,RPS25,RPS11,RPS27A,RPL38,RPS7,RPL7A,RPL26,RPS6,RPL10A,RPS12,RPS16,RPS24,RPS14,RPS3A,RPL7,RPL3,RPL22,RPL37A,RPLP2,RPS21,RPS28,RPL36AL,RPL36,RPS27L,RPL5,ETF1,RPL6,RPS15,RPS8,RPL32,RPS3,RPL37,RPS23,RPL35A,RPSA,EIF4G1,RPL23,NCBP1,RPS27,RPL31,RPL27,RPL19,RPL17,RPL27A,RPLP0,PABPC1,RPL3L,RPL10L,NCBP2,RPS19,RPL39L,RPS10,RPLP1,RPL35,RPL26L1,RPL30
R-HSA-72202	Transport of Mature Transcript to Cytoplasm	0.996644650860684	-0.00336099094693109	87	68	0.00752711976975869	9034	10285	80145,51692,6430,55339,10569,79023,11097,9688,55706,22794,6429,9818,26097,23165,100101267,51362,5903,8683,29107,22916,1977,23279,23511,9775,9972,23225,53371,6431,9984,9295,10898,4686,4927,7884,8563,6432,8021,9883,10250,8086,10189,9877,9631,81929,81608,10482,84248,84271,4116,10212,53981,7307,4928,7175,129401,23636,10762,11338,348995,55110,79902,84324,8189,6428,84321,6426,57122,55746	THOC7,CPSF3,SRSF5,WDR33,SLU7,NUP37,NUP42,NUP93,NDC1,CASC3,SRSF4,NUP58,CHTOP,NUP205,POM121C,CDC40,RANBP2,SRSF9,NXT1,NCBP2,EIF4E,NUP160,NUP188,EIF4A3,NUP153,NUP210,NUP54,SRSF6,THOC1,SRSF11,CPSF4,NCBP1,NUP88,SLBP,THOC5,SRSF7,NUP214,POM121,SRRM1,AAAS,ALYREF,ZC3H11A,NUP155,SEH1L,FIP1L1,NXF1,FYTTD1,POLDIP3,MAGOH,DDX39A,CPSF2,U2AF1,NUP98,TPR,NUP35,NUP62,NUP50,U2AF2,NUP43,MAGOHB,NUP85,SARNP,SYMPK,SRSF3,THOC3,SRSF1,NUP107,NUP133
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	0.996750516375428	-0.00325477466168664	117	93	0.0102944432145229	9034	10285	6227,6166,25873,8668,6128,6202,6167,6165,1981,8661,3921,7458,6232,6160,728689,6143,1983,6139,6175,6123,140801,51386,6176,200916,6138,6144,8664,6124,9045,6235,6159,6133,8669,6207,6230,6205,1974,27335,6154,6206,6129,8666,6146,8894,1965,6181,6168,6234,6125,51065,8665,8667,6209,6188,6161,6228,9349,6155,6157,1977,1975,116832,6223,6204,6156,51121,11224,6210,6164,23521,6136,10480,6224,6231,7311,6135,6137,6152,6142,8662,6169,6233,6201,6130,9669,4736,6194,6217,3646,6229,6208,6189,6122	RPS21,RPL36AL,RPL36,EIF3I,RPL6,RPS8,RPL37,RPL35A,EIF4G1,EIF3A,RPSA,EIF4H,RPS27,RPL31,EIF3CL,RPL19,EIF5,RPL17,RPLP0,RPL3L,RPL10L,EIF3L,RPLP1,RPL22L1,RPL15,RPL21,EIF3D,RPL4,RPL14,RPS29,RPL29,RPL9,EIF3J,RPS13,RPS25,RPS11,EIF4A2,EIF3K,RPL26,RPS12,RPL7,EIF3G,RPL22,EIF2S2,EIF2S1,RPLP2,RPL37A,RPS28,RPL5,RPS27L,EIF3F,EIF3H,RPS15,RPS3,RPL32,RPS23,RPL23,RPL27,RPL27A,EIF4E,EIF4B,RPL39L,RPS19,RPS10,RPL30,RPL26L1,RPL35,RPS15A,RPL34,RPL13A,RPL12,EIF3M,RPS20,RPS26,UBA52,RPL11,RPL13,RPL24,RPL18A,EIF3B,RPL38,RPS27A,RPS7,RPL7A,EIF5B,RPL10A,RPS6,RPS16,EIF3E,RPS24,RPS14,RPS3A,RPL3
R-HSA-77595	Processing of Intronless Pre-mRNAs	0.996891983415246	-0.00311285649925724	22	15	0.00166039406685853	9034	10285	51585,4686,79869,10914,10898,53981,1479,8106,81608,8189,55339,10978,22916,51692,23283	PCF11,NCBP1,CPSF7,PAPOLA,CPSF4,CPSF2,CSTF3,PABPN1,FIP1L1,SYMPK,WDR33,CLP1,NCBP2,CPSF3,CSTF2T
R-HSA-392499	Metabolism of proteins	0.996897246660848	-0.00310757685833778	1619	1389	0.1537524905911	9034	10285	79677,26085,9117,10585,9861,130576,22948,8607,267,55746,51588,10282,6347,8876,29843,53942,7979,1636,29925,5864,7341,56913,326624,340075,419,81792,2782,10130,11340,136,6734,55650,11031,4311,51201,161357,9709,51272,3416,57452,377630,2801,375,84269,2625,6774,5718,51322,4927,381,2999,374378,9736,8346,169026,10466,81929,8073,7369,6156,23016,1457,26985,221656,3309,147719,56005,5691,9510,9554,11095,84932,7020,5719,9688,8000,6745,64841,8787,10802,79823,1359,3313,8434,10694,1974,4792,6881,170689,4588,64409,5279,5373,9027,80070,6904,3623,9871,63971,4589,84516,55970,7321,254013,339366,4069,4758,5685,5874,22921,8357,3625,6189,81027,6487,8729,6194,116372,8314,3801,11336,29104,7709,6201,29090,5886,439,50614,10576,4189,55350,57799,4194,493861,5238,8350,811,6480,3952,84920,129401,3576,9382,2779,9632,8813,79609,3998,9656,55236,51604,7419,9627,6188,8665,7040,29080,7941,54872,118460,4583,2790,54742,154064,411,5708,7415,5861,420,51693,6729,6314,9091,51128,100500888,8669,23252,79139,5110,64135,286053,643847,3479,25950,6731,10342,51377,6232,55777,58530,7466,79748,51227,83752,79087,8702,8668,6728,6185,94025,1512,7375,6227,9507,8332,7874,2773,5611,5694,5887,10206,115827,26290,10164,25862,9100,10452,7278,374,353091,4585,84132,55808,7046,2804,1081,94235,7703,92609,347733,9781,1912,2395,9719,8818,25813,6146,8774,5715,2530,7324,93973,10232,4644,23326,90411,23770,57122,8877,80012,23478,121504,79369,8021,79145,821,7316,92912,30815,1155,402,1783,4247,6464,4000,8362,8678,6675,890,56254,11047,11014,1605,2629,100302237,6288,6000,400916,6712,4240,57506,10600,2922,8340,401505,10568,8078,8893,54734,372,805,23423,10417,10670,7175,2671,5713,8347,100101267,64772,1361,6204,2028,221395,6157,285362,3012,1603,23193,2137,9646,8786,22872,55288,58477,51764,5627,2215,5265,7057,8343,23243,6129,5717,29089,64426,23621,440689,4878,8890,57134,10054,26503,10238,94115,325,26088,2864,8875,55763,5692,9960,23256,8334,5710,170692,146760,143471,1459,4928,23163,4245,354,79642,9797,26515,728689,55291,29928,3703,440,5281,6128,64127,64924,332,1075,6670,567,2650,2626,51255,3646,51025,4312,10575,23586,79053,6622,2781,197258,51552,65264,85365,2935,9804,1780,7903,8345,8704,89978,4286,9276,6155,10954,346562,287,6746,1294,2107,2590,6234,29954,23471,3375,56052,22820,201475,2770,112714,808,3190,23145,5222,7417,253970,8358,9820,7276,1755,1663,50863,23265,9631,126961,5045,3484,10868,128312,29926,8720,1983,79861,51611,7048,55757,5686,6202,55907,8359,3091,123904,9628,59345,6489,5706,79875,8615,5885,2793,9215,9570,10970,3626,506,253827,10402,7518,8934,54926,51146,7322,2683,123228,10026,43,55611,360226,5203,9577,51121,374907,6223,7252,93183,10942,26986,54891,286,248,84749,643834,723790,8364,6161,3742,10440,11096,387,84101,6726,23137,8666,7416,7270,1725,6934,79090,23011,11226,90701,8841,1911,23275,324,1082,378,10693,5393,6483,7295,7277,56605,8353,27235,6143,55770,51726,153642,26270,3921,468,3020,433,5687,83729,7706,54543,8355,2688,197257,157869,6229,1511,9509,5707,338596,2517,100287932,5080,10960,30001,6613,9451,79694,5700,729238,51164,6231,93659,83696,408,84720,100313843,7045,6015,192134,4253,148867,10945,55432,349633,2784,11320,63908,641,55741,1540,125476,54780,9508,8869,6228,5862,6727,349667,54536,8667,7846,257194,11065,5071,6502,23556,7508,54764,653604,8312,137797,8348,10197,6159,57111,1803,83548,9045,9883,51046,64284,1431,5903,580,26958,55568,55033,6123,10427,8349,171019,5537,966,335,84752,4609,51734,4800,7058,8693,3481,55252,10318,84617,617,1453,10959,131118,11196,26234,54187,84620,219333,7109,6902,6711,50,5122,1639,407043,84002,51715,54959,4249,80896,22926,8361,6164,150,205564,3798,116832,100500827,10213,1471,3799,10540,6844,4287,5029,57646,4248,5872,114803,63917,80328,6125,6747,27090,114805,8128,84196,3339,152330,5905,140838,5340,10762,11231,7150,9445,117248,2153,5893,80731,3489,388753,51299,6133,9314,9063,4802,2931,6975,122706,1029,8341,6144,21,2695,80273,2677,10610,3018,4057,151194,1937,55901,7157,10477,1439,7991,5696,10981,11328,5972,10574,6484,6175,10897,5283,7458,991,91833,80351,8354,91869,26190,1215,51332,683,1122,3488,1360,10106,81876,51816,283899,3619,1522,6217,3817,348995,327,9486,5870,4597,6135,51807,8027,2243,11021,8368,10480,2155,3329,2783,6210,7007,200958,1977,2348,4241,79913,10055,590,22944,83475,22894,254263,29761,63891,51065,55676,9146,8766,249,5682,8339,5617,6206,4124,10966,9526,84628,27335,3670,8968,9101,632,51560,93010,6124,22845,432,10418,23480,3093,2081,23279,5069,23627,30827,23225,170690,1087,78990,1048,51809,91445,1981,6165,1080,394263,2488,8554,7486,8969,5589,25873,84342,1395,6730,5201,9097,5111,5867,8662,648,56957,100188893,27005,140766,23521,22931,10195,2791,4351,8604,7326,60412,51720,128637,51651,9114,390243,3312,5082,64122,5702,3630,9126,58485,27314,25834,55706,7314,9761,51226,5372,1967,23636,161725,6117,64689,29906,6154,4088,284348,6708,6207,79623,9527,6235,5624,8737,3800,26520,171169,115273,1778,145173,10020,11174,140801,9972,25839,8344,4089,10640,199857,79695,7189,5728,10474,23358,9246,2934,6709,6569,1043,801,6396,4736,135228,6169,6233,1915,134266,8703,1643,84447,2720,5443,118,55647,131474,83746,81847,1045,26517,221937,8924,22955,10469,170691,7327,10671,56942,116138,7320,4798,8335,4062,51010,7332,6168,23032,54507,123169,165918,84909,5526,60559,3013,79594,1801,10952,11093,55062,2099,22803,1936,1315,22854,5591,1984,55284,5073,266727,6996,22796,8365,81849,6138,26519,6672,8858,8900,10564,7021,8892,51143,6139,3483,4121,55294,2159,1509,2525,5690,84282,10274,2762,9818,7039,143662,9487,8363,2788,9669,79644,56667,79902,409,3816,4978,25837,6224,7311,56999,3015,6477,5423,56915,8975,5876,646627,29995,221613,7347,60676,55768,56648,23404,142,337,221981,196483,8535,23168,5204,10525,89866,3485,56160,11282,8767,2890,5126,2786,9545,26984,8360,126119,377,793,29880,9986,330,10071,10972,25924,2822,8570,90639,7280,285381,84261,6710,10299,5878,51762,4218,8367,10617,7844,23198,6176,467,55014,3068,54331,5695,1978,7334,51504,10890,8655,6400,4313,221143,51035,54732,84364,10254,9134,8970,56886,55176,27076,10331,120071,9945,7158,8724,6152,1938,6184,57171,3017,51014,80055,290,220441,6136,10196,1369,4092,7345,149111,86,90865,54965,1368,83452,27230,84142,4801,79931,3487,5693,79023,118430,727897,54617,10559,92949,2641,5371,146183,5868,4045,997,498,2589,6230,6205,5701,92815,10956,57599,9491,10652,6045,8370,54344,10113,148789,3972,9958,84790,10678,10825,51386,10175,2792,23511,442117,90268,64750,339122,8661,54623,9099,7323,5869,26286,10454,27095,6166,122553,9609,11173,4086,8581,401258,6885,2147,11227,79672,1917,653509,9789,149371,11316,197370,79577,140453,140687,1604,5067,9334,1200,27430,135,3021,796,5714,5329,10651,401409,10376,8790,79155,993,9212,8894,6468,11041,4061,55343,291,51602,2813,55135,100137049,7329,8086,284098,406974,22901,54927,7328,7353,57731,10869,55624,80267,9695,116150,8295,23062,6160,516,10165,79796,2350,9245,6167,29086,9037,6811,7841,6612,9929,11097,57332,6790,10681,338328,84892,6208,59343,100500842,11070,26330,4087,619373,7187,5865,7494,6441,168391,6142,64377,6048,100287144,2771,251,144245,898,672,5720,154,11236,288,128869,57559,29927,53371,120526,4482,9349,7264,114548,55577,167227,8915,3607,6209,10484,8352,57511,6181,6482,1965,1781,2787,1650,5873,84733,9488,10392,9868,2780,51301,256435,8366,10905,29929,80740,23682,8664,56993,7349,6478,37,200916,7155,57403,2591,26224,7070,5704,54437,79091,3624,6903,7528,11258,55738,6653,55031,51564,10445,22818,63967,10382,6406,7095,7128,183,6122,7153,51738,91949,83639,140735,5711,2673,60,100500853,8850,6130,329,81794,11015,146712,9512,3183,6137,2033,4122,5699,351,6439,7879,150274,5684,7022,8891,124872,375056,1499,10381,23165,4905,11224,8658,4193,1975,5698,23172,9810,23463,152,9817,6905,338557,79947,1802,57188,9331,8313,1363,3486,10528,26272,53917,57695	SMC6,KLK13,SEC22C,POMT1,PSMD6,LYPD6B,CCT5,RUVBL1,AMFR,NUP133,PIAS4,BET1,CCL2,VNN1,SENP1,CNTN5,SEM1,ACE,GMPPB,RAB3A,SUMO1,C1GALT1,RAB37,ARSI,ART3,ADAMTS12,GNB1,PDIA6,EXOSC8,ADORA2B,SRPRA,PIGV,RAB31,MME,ZDHHC2,MDGA2,HERPUD1,BET1L,IDE,GALNT16,USP17L2,GOLGA2,ARF1,CHCHD5,GATA3,STAT3,PSMD12,WAC,NUP88,ARF5,GZMH,GALNT18,USP34,H2BC10,SLC30A8,COG5,SEH1L,PTP4A2,UMOD,RPL30,EXOSC7,CSNK2A1,AP3M1,KDM1B,HSPA5,LYPD4,MYDGF,PSMB3,ADAMTS1,SEC22B,ADAMTS8,RAB2B,TFAP2A,PSMD13,NUP93,PSCA,SSR1,GNPNAT1,RGS9,SEC24A,CAMKMT,CPA3,HSPA9,RECK,CCT8,EIF4A2,NFKBIA,TAF10,ADAMTS15,MUC6,GALNT17,PIGC,PMM2,NAT8,ADAMTS20,TBCD,INHA,SEC24D,KIF13A,MUC7,DCTN5,GNG12,UBE2D1,ETFBKMT,ADAMTSL5,LYZ,NEU1,PSMA4,RAB27B,MSRB2,H3C10,INHBB,RPS3A,TUBB1,ST3GAL3,GBF1,RPS6,LYPD1,BAP1,KIFC3,EXOC3,N6AMT1,ZBTB17,RPS7,TIMM21,RAD23A,GET3,GALNT9,CCT2,DNAJB9,VNN3P,RAB40C,MDM4,EID3,PGM3,H3C1,CALR,ST6GAL1,LEP,ALG10,NUP35,CXCL8,COG1,GNAT1,SEC24C,DPM1,VCPKMT,LMAN1,MDC1,UBA6,PIGT,VDAC3,SNCAIP,RPS3,EIF3F,TGFB1,CCDC59,PLA2G7,PIGG,EXOSC6,MUC2,GNG10,LY6K,RAET1L,ARSB,PSMD2,VCP,RAB1A,ART4,TRAPPC2L,SRP54,ATXN7,PIGQ,SAR1B,MIR3940,EIF3J,OTUD3,DERL1,PCMT1,IFIH1,NSMCE2,PGA4,IGF1,RWDD3,SRP72,TFG,UCHL5,RPS27,MBD5,LY6G6D,WFS1,LMAN1L,PIGP,LONP2,ALG12,B4GALT4,EIF3I,SRP19,RPN2,MUC16,CTSH,USP4,RPS21,ADAMTS4,H2AC16,USP7,GNAI3,DNAJC3,PSMB6,RAD23B,TRIM13,RAB3C,GALNT8,CHST4,USP49,USP10,TOMM40,TUBA3C,AREG,RAET1G,MUC4,USP42,ST6GALNAC1,TGFBR1,GOLGB1,CGA,GNG8,PCGF2,TIMM50,TUBB2B,RNF144A,PHC2,FXN,ADAMTSL2,DPM2,SAMM50,RPL22,NAPG,PSMD9,FUT8,UBE2E1,ACTR8,MSLN,MYO5A,USP22,MCFD2,FKBP8,NUP107,SPHK1,PHC3,SEC11A,H4C16,B3GNT4,NUP214,CHCHD7,CANX,UBC,UBE2Q2,ST6GALNAC6,TBCB,ARL2,DYNC1LI2,MGAT2,SHC1,LMNA,H4C12,BECN1,UAP1,CCNA2,RNF20,ADRM1,KDELR2,DAG1,GBA1,MIR1281,SAA1,RGS7,CHCHD10,SPTBN2,MFGE8,MAVS,USP16,GRP,H2BC13,TOMM5,SLC34A2,USP5,EIF2B5,RAB39A,ARCN1,CALM2,TMED3,SPON2,RRAGA,TPR,GFER,PSMD7,H2BC4,POM121C,ENGASE,CPB2,RPS10,ENPEP,ADGRF5,RPL27A,SUMF1,H2AC8,DAD1,GANAB,EXTL3,CTR9,RGS11,SEC31A,RHOT1,SRPRB,GNG13,PROS1,FCGR3B,SERPINA1,THBS1,H2BC7,ANKRD28,RPL7,PSMD11,UBE2T,SUDS3,BACE1,H2BC18,NPPA,EIF2B4,MAN1C1,UBA2,SLC17A5,DCAF7,CGB8,APCS,GGA1,FFAR1,VNN2,EXOC1,PSMB4,USP3,SCFD1,H2AC6,PSMD4,ADAMTS18,RTN4RL1,PSMA8,CSNK2A2,NUP98,GGA3,MGAT1,KLK3,ARSJ,TATDN2,TIMM10B,EIF3CL,PPP6R3,TIMM22,STT3A,ASNS,PIGF,RPL6,NOD2,SLC30A5,BIRC5,CTSC,SP3,B2M,GCNT1,GATA4,RNF181,EIF3E,PAM16,MMP1,CCT4,RIGI,ALG8,SNCA,GNAZ,FCSK,RAB14,UBE2Z,ALG2,GSPT1,TOMM20,DYNC1I1,ST8SIA4,H2BC9,B4GALT2,DPH6,MITF,COPB2,RPL27,PDIA5,GNAT3,ANK2,SSR2,COL7A1,ETF1,GALNT2,RPS28,POMT2,TRAM1,IAPP,ALG1,COPG1,RAB12,GNAI1,TUBA3E,CALM3,HNRNPK,SSPOP,PGA5,VDAC2,SFTA3,H3C2,CUL7,TTR,DMBT1,DDX11,NTM,EXOC7,NUP155,H3C14,FURIN,IGFBP1,USP20,H2BC26,GMPPA,MBTPS1,EIF5,TUBAL3,DPH5,TGFBR2,UGGT2,PSMA5,RPS8,CMAS,H4C1,HIF1A,NRN1L,RGS6,GNB4,ST8SIA1,PSMC6,THSD4,USO1,RAD21,GNGT2,LARGE1,GOSR2,CKAP4,INHBC,ATP5F1B,MSRB3,ST3GAL6,XRCC4,RAB29,UBE2R2,A4GNT,UBE2D2,B4GALT1,SENP8,PIGK,ACHE,OTUB1,PRSS41,PFDN4,BABAM2,RPL26L1,B3GNT8,RPS19,TSHB,PIGM,PRSS21,PABPC1,INO80D,ANK1,ALPI,USP30,PGA3,H2AC19,H4C3,RPL32,KCNA6,TIMM17A,ADAMTS5,RHOA,USP44,SRP9,SMC5,EIF3G,VDAC1,TTF1,DHPS,TCF7L2,TRAPPC6A,RAB21,GALNT6,SEC11C,HDAC3,PHC1,POFUT2,APC,CGB3,ARF4,CCT6B,EXOSC9,ST3GAL2,TXN,TUBA4A,ERO1B,H3C6,COQ2,RPL19,EXOC2,DNAJB11,ARSK,FBXO6,RPSA,ATF4,H3-3A,ASGR2,PSMA6,INHBE,TRIM25,TOMM7,H3C8,GH1,LDHD,SBSPON,RPS24,CTSG,ADAMTS2,PSMD1,ST8SIA6,FUCA1,TIMM23,PAX6,LMAN2,ERO1A,SUMO2,EIF2AK3,MANEA,PSMC1,SFTPA2,DCTN4,RPS26,CGB5,TRAPPC9,ARRB1,PIGO,MIR711,TGFBI,RING1,B3GNT6,MIA2,SLC30A7,KDELR1,YOD1,PLET1,GNB3,MGAT4A,NAPB,BLM,EDEM2,CYLD,INO80C,NSMCE4A,ADAMTS3,ST3GAL5,RPS23,RAB2A,SRP14,RTN4RL2,EXOC6,EIF3H,TUBA1A,NEGR1,UBE2C,PRKN,SKP2,PIGN,XPC,ZRANB1,H3C13,AXIN1,LYPD2,H2BC17,PSME3,RPL29,RAB25,DPP4,COG3,RPL14,POM121,ST8SIA3,RAB17,CS,RANBP2,BARD1,COPG2,GALNT10,FKBP14,RPL3L,SEC24B,H2BC21,ADAMTS19,PPP6C,CD59,APOA1,B3GNT9,MYC,MSRB1,NFYA,THBS2,GALNT4,IGF2,ASXL2,TNIP1,TUBB6,BCS1L,CSNK1D,TMED2,DNAJC19,SEC23IP,FBXL5,NANS,ST6GAL2,USP12,TRAPPC10,TBCA,SPTBN1,ACO2,PCSK1,DCTN1,MIR7-1,B3GNT5,RAB23,ODAM,MGAT5,NPL,ATF6,H4C6,RPL34,ADRA2A,SENP5,KIF5A,RPL39L,MIR3614,PSMD14,CST3,KIF5B,DCTN2,VAMP2,ATXN3,P2RY2,USP28,MGAT3,RAB13,MYSM1,GALNT11,ULBP2,RPL5,SSR3,ST6GALNAC4,GALNT13,ST8SIA2,USP48,HSPG2,CNTN4,RANGAP1,NANP,PLG,NUP50,SEC63,TOP1,ITM2B,GALNT15,F5,RAD52,THSD7B,IGFBP6,COA6,NRN1,RPL9,KLF4,PIAS2,NFYC,GSK3A,TECTB,PSMB11,CDKN2A,H2BC15,RPL21,ABCA3,GIP,GRPEL1,GGCX,ST6GALNAC2,H2BC3,LTF,METTL21A,EEF1G,THSD1,TP53,UBE2E3,CSF2RB,TUSC3,PSMB8,RAB32,FKBP9,REN,CCT7,ST3GAL4,RPLP0,YIF1A,PIGH,EIF4H,CDC20,WDR20,TNKS2,H3C11,RFT1,FBXW2,CMA1,SPTBN5,BST1,CHML,IGFBP5,CPB1,CTDSP2,RAB1B,ADA2,INO80E,INCENP,CTSZ,RPS16,KLK2,NUP43,APEH,CHST10,RAB6A,MVD,RPL11,TUBA8,STAM,FGA,RAB35,H4C13,EIF3M,F7,HSPD1,GNB2,RPS15A,TECTA,MUC20,EIF4E,FOLR1,MELTF,ACTR5,SAE1,BCHE,KIN,DOHH,DIS3,CNIH2,USP25,RNF123,RPS27L,SLC30A6,HGS,RAB11A,ALPL,PSMA1,H2BC8,PRL,RPS12,MAN2A1,RAB40B,MPDU1,NTNG2,EIF3K,ISL1,H3C7,USP8,BGLAP,RAB6B,B3GNT7,RPL4,DOLK,ASGR1,SPON1,SEC61G,UBE2K,ERN1,NUP160,PAPPA,PRND,CXXC1,NUP210,ADAMTS16,CEACAM7,OTUB2,CEACAM5,GALNT7,RNF185,EIF4G1,RPL35A,CFTR,MUC21,FSHB,PIAS1,WRN,H2AC11,PRKCSH,RPL36,COG8,CRHR2,SRP68,PFDN1,USP14,PCNA,RAB4A,EIF3B,BMI1,OTUD7B,TOMM6,USP21,ADAMTS14,RPL13A,RAB18,ALG3,GNG11,MPI,SLC25A12,UBE2G1,EXOC4,UIMC1,TBC1D20,PTRH2,ATP6V0D1,IZUMO1R,HSPA8,PDCL,FN3K,PSMC3,INS,SMC3,TRAPPC1,RAB30,MGAT4C,NDC1,UBB,MLEC,COPZ2,PMM1,EIF2B1,NUP62,OTUD7A,RPA1,GORASP1,ST8SIA5,RPL26,SMAD3,LYPD5,SPTA1,RPS13,GALNT14,GOSR1,RPS29,PROC,RIPK1,KIF5C,TIMM9,SPACA4,RAB42,DYNC1H1,B3GLCT,GNE,ADAMTS6,RPL10L,NUP153,COG4,H2BC6,SMAD4,EXOC5,ALG14,GALNT12,TRAF6,PTEN,TADA3,USP24,UBE2L6,GSN,SPTAN1,SLC34A1,CD52,CALM1,SEC13,RPL10A,CD109,RPL38,RPS27A,EEF1A1,GRPEL2,B4GALT3,DDB2,SYVN1,GLB1,POMC,ADD1,RAB20,CHCHD4,L3MBTL2,RNF146,CDX2,TIMM13,FOXK1,HERC2,SCMH1,TIMM44,ADAMTS17,UBE2G2,DCTN6,CMC2,KLHDC3,UBE2B,NFRKB,H2AC4,LY6H,EXOSC3,UBE2L3,RPL37A,USP33,ADAMTSL4,LEO1,RNF168,AOPEP,PPP2R5B,SPCS3,H2AC7,MUL1,DPH1,SEC61B,ADAMTS13,WIPI1,ESR1,XRN2,EEF1D,COPB1,NTNG1,PRKDC,EIF5A,UBE2W,PARN,MDGA1,TDG,COG2,H4C8,ST6GALNAC5,RPL15,TIMM10,SP100,PROZ,CCNA1,ARFGEF2,TFAP2B,EIF2B2,DYNC1LI1,RPL17,IGFALS,MAN1A1,FBXW7,F10,CTSD,FUT3,PSMB2,RNF135,STAG1,GMDS,NUP58,TGFA,MUC15,PIGL,H4C11,GNG7,EIF5B,SRD5A3,MUC13,NUP85,ARRB2,KLK1,OPCML,RAB26,RPS20,UBA52,ADAMTS9,H2AZ1,SIAH1,POLB,EXOSC5,USP13,RABGGTB,LYPD8,LMCD1,H2AC1,UCHL3,PAPPA2,NGLY1,EIF5A2,EXOSC2,PARP1,APOA4,THSD7A,EEF2KMT,CBX4,RTF1,PFDN5,HYOU1,SEC16B,IGFBP2,NSMCE3,MGAT4B,RIPK2,GRIA1,PCSK2,GNG4,RAB3D,SEC22A,H4C4,JOSD2,ARF3,CALB1,ALG5,RCE1,BIRC3,MUC12,TMED10,MYRIP,GPLD1,KHSRP,COX19,TUBB2A,DPH3,FBXW9,SPTB,MARCHF6,RAB5C,RAB8B,RAB8A,H4C5,STAMBP,RNF103,PSME4,RPLP1,ATF3,STX17,HDGF,GNG2,PSMB7,EIF4EBP1,UBE2N,TRMT112,RAB10,DYNLL1,SEL1L,MMP2,EEF1AKMT1,UBXN1,TMED9,ARFGAP2,STAM2,CCNE2,H2BC11,UGGT1,SEC61A2,LYPD3,B3GNT3,LARGE2,GFPT2,TP53BP1,SNX3,RPL24,EEF2,RPN1,DOLPP1,H2BC5,TMED7,PGAP1,ANPEP,RNF152,RPL12,PRMT3,CPN1,SMAD7,UCHL1,CNIH3,ACTL6A,IL33,PIGX,CPM,RAB33B,SERP1,ABRAXAS1,NFYB,TNIP3,IGFBP4,PSMB5,NUP37,MUCL1,MUC5B,INO80,SLC35A1,ADAMTSL1,GCG,PML,OTOA,RAB5A,LSAMP,CDC34,ATP5F1A,GALNT1,RPS25,RPS11,PSMC2,H2AC25,OS9,WDR48,PSMF1,YKT6,RNF2,H4C14,DPM3,PREB,B3GALNT2,LHB,USP15,TUBA1C,B3GNT2,NEU3,EIF3L,CNIH1,GNGT1,NUP188,GALNTL6,OTULIN,SMURF2,RAB43,EIF3A,PAF1,USP2,UBE2D3,RAB5B,ARFGAP3,TAB1,TRAPPC3,RPL36AL,TRAPPC6B,RAB36,ADAMTS7,SMAD1,LY6D,RAB44,MAP3K7,F2,GALNT5,FN3KRP,EEF1A2,SFTPA1,SPCS2,EXOC8,COPE,NSMCE1,CDC73,MUC17,GCNT7,CD55,CNTN3,B4GALT5,TPP1,MAT2B,ADORA2A,H3-3B,CALCA,PSMD8,PLAUR,MTX2,RAB19,TUBA1B,FPGT,TNIP2,CDC25A,AURKB,EIF2S2,FBXW4,B4GAT1,LY6E,SLC35C1,SLC25A4,NOP58,GP2,WRAP53,PLA2G4B,UBE2I,AAAS,PIGW,MIR197,ARSG,CHCHD3,UBE2H,UFD1,SPTBN4,USP19,POMGNT1,EDEM3,EDEM1,NUS1,TRRAP,GGA2,RPL31,ATP5MC1,SLC25A13,ALG9,FOLR2,GCNT3,RPL37,BABAM1,SEMA5A,STX5,MOGS,SUMO3,JOSD1,NUP42,CBX8,AURKA,GNB5,GPIHBP1,POMGNT2,RPS14,SENP2,MIR3652,TMEM115,GAPDHS,SMAD2,MBOAT4,TRAF3,RAB3B,XBP1,SFTPD,GALNTL5,RPL18A,CHST8,RNF5,USP17L10,GNAI2,ALPG,ALG10B,CCNE1,BRCA1,PSME1,ADRB2,RNF139,ANK3,PIGU,STAMBPL1,SEC61A1,NUP54,DNAJC24,MSRA,RPL23,GFUS,NLRP3,NAGK,DCP2,BCL10,FOXK2,RPS15,SEC23A,H3C3,COG6,RPLP2,ST3GAL1,EIF2S1,DYNC1I2,GNG5,DDOST,RAB27A,CBX2,PIGB,NOD1,TOMM70,GNAT2,GCNT4,ST6GALNAC3,H4C2,MAN1A2,ALG6,LY6G6C,RAB38,EIF3D,TOMM22,UCN,SIAH2,ACADVL,RPL22L1,TOP2B,RAB22A,GALNT3,FBXL3,THY1,PSMC4,SEMA5B,METTL22,INHBA,TBCC,YY1,DCTN3,ARFGAP1,SORL1,USP47,HDAC7,MCRS1,COPZ1,CLSPN,TUBB4A,SEMG1,SEC62,TNFAIP3,AGT,RPL3,TOP2A,GHRL,COG7,TEX101,DYNLL2,PSMD5,GFPT1,ACTB,MIR3605,KAT2B,RPL7A,BIRC2,ADAMTS10,KDELR3,B3GNTL1,PMPCB,HNRNPC,RPL13,EP300,MAN2A2,PSMB10,APP,SFTPB,RAB7A,HSCB,PSMA3,TFAP2C,EIF2B3,B4GALNT2,MIA3,CTNNB1,TUBB3,NUP205,NSF,RPL35,TNKS,MDM2,EIF4B,PSMB9,ABRAXAS2,RNF40,ICMT,ADRA2C,KEAP1,TBCE,FFAR4,DHDDS,DPH2,ADAMTSL3,B4GALT6,AXIN2,CPE,IGFBP3,NOP56,FBXO4,RAB24,USP37
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	0.997079804796191	-0.00292446729273902	110	87	0.0096302855877795	9034	10285	9014,8968,653604,902,8358,5434,1786,25885,3013,8363,79685,8467,8340,11176,64425,8339,8357,5441,8355,8343,79101,8970,8819,10849,7270,64426,8360,84172,8361,8347,8353,5440,8345,8932,8350,94239,8341,8370,8365,126961,3018,8367,23309,3017,8368,3015,8346,8334,1022,404672,8348,121504,8366,3012,3066,221830,8354,55766,79595,3021,8349,4331,3065,128312,2068,9015,8362,7343,51082,51742,23411,8352,9533,8359,8335,2968,25942,8364,3020,29115,23378,2965,2967,10284,2071,8344,723790	TAF1B,H3C7,H3C13,CCNH,H3C2,POLR2E,DNMT1,POLR1A,H2AC7,H4C11,SAP30L,SMARCA5,H2BC13,BAZ2A,POLR1E,H2BC8,H3C10,POLR2L,H3C8,H2BC7,TAF1D,H2BC11,SAP30,POLR1G,TTF1,SUDS3,H4C4,POLR1B,H4C6,H2BC4,H3C6,POLR2K,H2BC9,MBD2,H3C1,H2AZ2,H2BC15,H4C14,H4C8,H3C14,H2BC3,H4C5,SIN3B,H2BC5,H4C13,H2AZ1,H2BC10,H2AC6,CDK7,GTF2H5,H2BC17,H4C16,H4C2,H2AC8,HDAC2,POLR1F,H3C11,H2AJ,SAP130,H3-3B,H2BC21,MNAT1,HDAC1,H2BC26,ERCC2,TAF1A,H4C12,UBTF,POLR1D,ARID4B,SIRT1,H3C3,POLR1C,H4C1,H2AC4,GTF2H4,SIN3A,H4C3,H3-3A,SAP30BP,RRP8,GTF2H1,GTF2H3,SAP18,ERCC3,H2BC6,H2AC19
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	0.997093132267664	-0.00291110087779508	63	48	0.00531326101394731	9034	10285	1977,1975,26986,6223,51386,6204,6232,7458,1978,728689,6209,6202,6188,8665,8667,3921,8661,1981,6228,6227,8666,8894,1965,51065,8668,6234,3646,6206,6217,6229,6194,6208,6189,6207,6230,6205,8669,8662,27335,6233,1974,6201,6235,10480,6224,6231,6210,8664	EIF4E,EIF4B,PABPC1,RPS19,EIF3L,RPS10,RPS27,EIF4H,EIF4EBP1,EIF3CL,RPS15,RPS8,RPS3,EIF3F,EIF3H,RPSA,EIF3A,EIF4G1,RPS23,RPS21,EIF3G,EIF2S2,EIF2S1,RPS27L,EIF3I,RPS28,EIF3E,RPS12,RPS16,RPS24,RPS6,RPS14,RPS3A,RPS13,RPS25,RPS11,EIF3J,EIF3B,EIF3K,RPS27A,EIF4A2,RPS7,RPS29,EIF3M,RPS20,RPS26,RPS15A,EIF3D
R-HSA-212300	PRC2 methylates histones and DNA	0.997252877037234	-0.00275090322987812	74	57	0.00630949745406243	9034	10285	8363,23512,8340,8343,8970,8355,8357,8339,5928,2146,8360,653604,8968,1788,8358,1786,3013,3015,8368,3017,8334,8346,8348,8366,121504,121536,8361,8345,8353,8347,8370,8341,94239,3720,5252,8350,8367,126961,3018,8365,8349,26147,128312,8362,3012,8354,55766,3021,3020,8364,8726,8344,723790,22823,8335,8359,8352	H4C11,SUZ12,H2BC13,H2BC7,H2BC11,H3C8,H3C10,H2BC8,RBBP4,EZH2,H4C4,H3C13,H3C7,DNMT3A,H3C2,DNMT1,H2AC7,H2AZ1,H4C13,H2BC5,H2AC6,H2BC10,H2BC17,H4C2,H4C16,AEBP2,H4C6,H2BC9,H3C6,H2BC4,H4C14,H2BC15,H2AZ2,JARID2,PHF1,H3C1,H4C5,H3C14,H2BC3,H4C8,H2BC21,PHF19,H2BC26,H4C12,H2AC8,H3C11,H2AJ,H3-3B,H3-3A,H4C3,EED,H2BC6,H2AC19,MTF2,H2AC4,H4C1,H3C3
R-HSA-1660662	Glycosphingolipid metabolism	0.997442454771483	-0.00256082133436593	46	34	0.00376355988487934	9034	10285	57733,7357,6609,56624,22901,2760,4758,23344,80772,2581,6610,51228,2629,3074,2720,55627,64781,2583,153642,79411,5660,7368,285362,83850,340075,427,79642,411,57704,8706,10825,339221,57488,55512	GBA3,UGCG,SMPD1,ASAH2,ARSG,GM2A,NEU1,ESYT1,CPTP,GALC,SMPD2,GLTP,GBA1,HEXB,GLB1,SMPD4,CERK,B4GALNT1,ARSK,GLB1L,PSAP,UGT8,SUMF1,ESYT3,ARSI,ASAH1,ARSJ,ARSB,GBA2,B3GALNT1,NEU3,ENPP7,ESYT2,SMPD3
R-HSA-74160	Gene Expression	0.997470977138946	-0.00253222624145752	1821	1564	0.17312375470445	9034	10285	146542,80789,8427,1786,6794,92285,7407,10607,57472,8361,6164,136051,5439,4343,6897,7536,23536,6875,6636,57510,5595,407043,6009,10262,730087,219988,7025,9295,221830,9277,7692,79595,79759,116832,7710,162239,440519,10213,57604,115196,122402,55004,27153,6125,55687,6747,84441,1340,2521,91801,9416,84924,653604,6426,545,10793,6873,7768,23405,7625,55703,6923,387032,8896,9045,7936,9883,10524,10197,8348,6159,4609,1956,29959,53615,51592,22835,26512,54205,162972,6123,51728,8349,5903,580,7576,5170,1453,440515,100616459,147948,7769,113802,55813,100302242,10556,5707,51276,57505,57721,6229,5395,8355,5441,25937,29960,55726,10189,54790,124446,9136,23524,81605,10885,90338,5700,404672,192670,93659,3178,6231,1327,9984,10413,11200,10199,641,7738,51742,619279,2968,6727,8667,115509,29115,116228,51118,9092,6228,23379,5468,11056,84883,10780,25885,1994,29128,27292,90701,5519,6446,7270,9692,9891,51741,8353,5252,5393,7295,1082,79760,10128,23309,1017,10286,7913,6143,163087,5305,10498,79871,355,374655,9219,5687,7566,55615,5469,3020,11198,7376,5518,8726,55888,3921,1111,55699,51067,57677,220988,10767,1665,22984,55659,4292,7469,5706,6618,2516,5465,23054,10465,84124,84874,11102,55840,79109,9439,54881,833,55802,5308,2963,94039,581,25926,79370,129685,1350,133383,26986,138474,4331,4854,80153,127396,51639,51121,56006,6223,6258,83860,6726,79050,7581,11260,8666,5515,104,8013,7733,9031,8364,6161,6619,158399,1616,6882,723790,7773,8358,7862,9970,353088,7181,3190,10438,10111,9716,65123,10236,1024,84172,253260,155054,148213,9724,9631,5883,126961,339500,58484,23160,55174,8732,1983,10622,7700,4869,51520,128312,23774,6667,10000,25942,284119,8359,51077,6202,79898,2965,5915,5686,7567,57690,11335,92856,9441,29028,23438,6095,253639,3516,9377,3646,199704,2626,1787,10849,10650,121536,6637,8345,5451,27341,2935,5366,4605,148206,200315,55759,10667,79074,57103,7832,2100,6155,79922,282890,144455,51645,9410,348,388567,92595,5984,57819,23471,5433,143689,6234,26013,23350,55339,2107,284459,6746,27244,91875,94115,81857,80312,8890,64065,4603,4361,4878,8794,8343,10224,5717,6129,64426,4928,51585,51637,5710,143471,1459,200424,6432,10073,58528,8334,24148,8851,5976,54989,7029,54973,5692,4670,2975,23112,9330,25973,4929,147923,728689,57461,9775,6879,285349,9790,27125,57060,55660,332,4677,7421,9612,54456,6128,10769,2091,9337,9167,8125,22823,283989,8893,3181,7767,6097,2193,55571,11176,8340,10799,6607,10670,7175,1030,5713,8347,6635,1022,83695,3276,7760,4809,440077,3012,55039,91646,10514,163255,3735,6157,7050,100101267,10946,29107,1432,6204,80205,55197,10642,23451,60436,29974,8621,58477,81890,255403,11218,85441,9646,57122,7533,84914,90874,54974,58490,54514,56902,5715,6633,6749,7316,5578,8932,7001,401509,169841,27350,90459,10285,8021,2177,23478,121504,890,25904,54555,55718,7551,1387,79973,9924,65988,100131980,2103,84775,22916,389114,6884,390927,8431,27042,8362,25946,51690,25896,5430,83744,4697,55677,2071,100302237,84991,84705,199692,1869,57508,7770,5694,64859,8819,10397,7874,6434,387338,5467,7307,81608,28956,100129543,1660,6301,170959,10898,196513,388566,83732,1081,22794,7965,6146,9533,201164,27258,79622,162963,8487,6729,9014,100500888,353274,8669,113179,8189,114026,147837,25888,26152,171392,57794,5708,11066,118460,604,163071,79970,90075,10930,6731,85403,839,1329,51808,117608,9975,7296,6232,2960,5094,2744,6256,10419,56242,1353,6227,5442,54888,10370,2649,90649,8449,54700,8668,6185,6728,57711,983,5982,5917,2967,133746,7565,9521,29104,88745,6201,5565,995,6194,8357,8445,6189,84135,639,55367,129401,8350,10907,4194,6940,9477,3315,84671,8731,9656,93134,283742,891,152687,54802,3184,54482,7568,1615,57547,9310,57703,80139,6188,8665,403314,5516,147694,64216,4904,6881,6617,1974,22974,64425,11017,22827,7582,50484,79707,26168,23660,25824,2074,51586,10482,84248,5563,4641,124411,28996,55835,7752,7321,51367,90594,84944,55621,26147,79664,54517,900,5300,5916,10520,9422,7694,56165,339327,5685,168374,55900,7004,677,59348,29079,112858,6606,5718,51333,100913187,6428,9887,349075,7422,9611,57615,7766,6096,11338,10291,2936,80746,26149,51202,4774,6877,81929,54925,8346,4927,10025,5691,5892,7027,5859,85437,2475,6431,8780,27154,163223,6156,23016,1457,1345,207,6429,2058,5241,5719,9688,6745,56259,9582,3376,163049,7020,80145,162655,843,665,9969,10523,23517,284309,55746,1788,84324,90317,9861,55954,7627,2064,2908,7538,7979,79084,2176,197320,79718,51224,51003,55240,84246,10794,1875,7978,2976,7341,1386,126231,5452,84765,26019,5933,55272,199777,57050,11340,9442,6734,134353,158431,8850,6130,55253,255967,5711,3815,60,6122,81856,80222,7005,25929,54913,100616394,654254,9328,5684,7022,51593,8891,3183,6137,7695,2033,112950,5699,7571,2957,374879,4193,1975,5698,3065,1026,9329,23165,11224,10062,10528,10848,55656,3486,11073,10284,8741,79897,84265,221785,56339,3185,6629,1650,51095,11157,80032,6827,84321,5608,83990,7003,7529,10212,348180,200916,8664,5457,6631,162699,84271,80324,79047,163050,7531,79788,9440,8366,121274,100302168,84436,80095,27327,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PSMA6,ZNF18,PRR5,MED1,H3-3A,SUPT16H,NR1H2,PPP2R1A,EED,ZKSCAN7,RPSA,CHEK1,IARS2,YARS2,ZFP14,HNRNPA3,HBS1L,DHX15,PDCD11,ZNF416,MLH1,NELFA,PSMC6,SNAPC2,NR5A1,PPARA,NCOA6,PPIH,ZNF394,ZNF514,RPP14,EAF2,MAPKAP1,MED23,TEX10,CARS1,DCP1A,PITX2,GTF2F2,ZNF101,BAX,NOL11,BCL2L14,TAF8,COX7C,SETD9,PABPC1,TAF1L,MNAT1,NOTCH3,EDC3,ZNF684,SF3B6,RPL26L1,SMG9,RPS19,RXRG,TAF3,SRP9,NOC4L,ZNF33A,XPOT,EIF3G,PPP2CA,ADARB1,NR4A3,ZNF180,BAZ1B,H4C3,RPL32,SNAPC3,ZNF483,DAXX,TAF11,H2AC19,ZNF230,H3C2,BRPF1,NR1I3,ZNF429,NR2C1,HNRNPK,C1D,RAD50,AQR,INTS3,HNRNPR,CDK8,POLR1B,RICTOR,ZNF425,ZNF681,UTP14C,NUP155,RAD9A,H3C14,ZNF678,NLRC4,WDR43,INTS10,RNGTT,EIF5,POLR3G,ZNF141,NPM1,LARS1,H2BC26,BRD1,SP1,AKT3,SIN3A,CAVIN1,H4C1,FCF1,RPS8,ZNF613,GTF2H1,RARB,PSMA5,ZNF19,TNRC6C,CBX3,IMP4,MED26,ATAD2,HARS2,RORA,ZNF620,RBPJ,COX5A,EIF3E,ZNF585A,GATA4,TRDMT1,POLR1G,PRELID3A,AEBP2,SNRPG,H2BC9,POU2F1,RRP7A,GSPT1,PMAIP1,MYBL2,ZNF714,APOBEC3A,WDR12,FARS2,C2orf49,TIGAR,BTG2,ESR2,RPL27,MRM1,ZNF311,E2F7,PPIL1,SNRNP40,APOE,ZNF749,ZNF764,RFC4,LSM2,TRAM1,POLR2D,PIWIL4,RPS28,L3MBTL1,U2SURP,WDR33,ETF1,ZNF875,SSR2,SESN1,TTC5,CGB8,MED25,TET1,EIF2B4,PERP,MYBL1,MRE11,NPPA,TNFRSF10C,H2BC7,ZNF443,PSMD11,RPL7,SUDS3,NUP98,PCF11,RTRAF,PSMD4,PSMA8,CSNK2A2,TET3,SRSF7,SNUPN,RRAGD,H2AC6,PRPF6,CDK5R1,UPF1,ZNF770,TFDP2,INTS11,PSMB4,HNRNPM,GTF3C1,TNRC6B,GTF3C3,PARS2,NR4A2,ZNF420,EIF3CL,ISY1,EIF4A3,TAF7,ZNF660,BMS1,AFF4,PCBP4,PRPF40A,BIRC5,NARS1,VDR,NCOR2,MOV10L1,RPL6,PLK2,FBL,CNOT8,COX7A2L,ANP32A,MTF2,TSEN54,EIF2B5,HNRNPA2B1,ZNF224,RORC,FARSA,CNOT11,BAZ2A,H2BC13,RPP40,SMN2,RRAGA,TPR,CDKN2B,PSMD7,H2BC4,SNRPE,CDK7,RHNO1,PRMT1,ZNF213,SNU13,ZNF705A,H2AC8,TRMT12,TDRD12,MYBBP1A,ZNF540,KARS1,RPL27A,TGIF1,POM121C,SF3A3,NXT1,MAPK14,RPS10,CHD9,RPRD1A,IGF2BP1,SF3B1,TGIF2,A1CF,CDK13,SRPRB,QTRT1,ZNF718,DDX20,HELZ2,CTR9,NUP107,YWHAH,ZNF587,ZNF697,THG1L,RPRD1B,DDX4,PNO1,PSMD9,SNRPD2,SSRP1,UBC,PRKCA,MBD2,PRDX2,ZNF658B,ZNF169,APOBEC3C,ERI1,SMNDC1,NUP214,FANCD2,SEC11A,H4C16,CCNA2,CNOT10,DDX49,POLR3E,ZNF3,CREBBP,ZNF442,PAN2,ZNF747,ZNF705G,ESRRB,ZNF607,NCBP2,ZNF662,TAF13,ZNF793,NR0B2,UTP25,H4C12,ZNF385A,LSM7,INTS7,POLR2A,ZNF484,NDUFA4,IWS1,ERCC3,MIR1281,RBM17,GTPBP3,ZNF627,E2F1,INTS2,ZNF227,PSMB6,NABP1,SAP30,NDRG1,USP7,TRA2B,NSUN4,PPARD,U2AF1,FIP1L1,LAMTOR2,ZNF730,DHX9,SARS1,ZNF431,CPSF4,DCP1B,ZNF470,RIOK1,CGA,CASC3,AIMP2,RPL22,POLR1C,PLD6,LSM3,SNRNP25,ZNF610,GEMIN2,SRP54,TAF1B,MIR3940,ZNF445,EIF3J,ADAT3,SYMPK,ZIM3,ZNF563,ZNF473,ZNF337,ZNF675,SUGP1,PSMD2,SNRNP35,EXOSC6,BCL6,ZNF114,ZNF767P,ZNF30,APOBEC2,SRP72,EAF1,CASP6,COX5B,PHAX,ZNF354B,NR1D2,TXNRD1,RPS27,GTF2E1,PCBP2,GLS,RXRA,PRMT5,ZNF253,COX11,RPS21,POLRMT,NSUN2,CITED2,NR6A1,ZNF486,DHX16,RRN3,EIF3I,RPN2,SRP19,ZNF529,CDK1,RFC2,RARS1,GTF2H3,JMY,ZNF17,EEF1E1,N6AMT1,RRP36,RPS7,PRKAB2,CDC25C,RPS6,H3C10,DYRK2,RPS3A,UTP15,PRDM1,PIDD1,NUP35,H3C1,TXNL4A,MDM4,ZNF354A,MED20,HSPB1,ZNF347,RNMT,MDC1,ZNF561,FAM98B,CCNB1,ZNF595,TRIT1,HNRNPD,TRMT13,ZNF20,DARS1,ZNF624,ZNF235,CWC22,ZNF703,RPS3,EIF3F,APOBEC4,PPP2CB,ZNF548,TFB2M,YBX1,TAF10,SNAPC1,EIF4A2,TPX2,POLR1E,SNRNP27,PUF60,ZNF33B,RRM2B,NOL9,SENP3,ZKSCAN5,PRDX5,ERCC6,MED15,NXF1,FYTTD1,PRKAA2,MYO1C,KRBOX5,HIPK2,CENPJ,ZNF200,UBE2D1,POP5,ZNF439,MAEL,TRMT1,PHF19,ICE2,PUS7,CCNG1,PIN1,RARG,ZNF211,ZNF264,ZNF135,TDRD1,ZNF546,PSMA4,ZNF92,ZNF302,TEAD4,ZFP36L1,ZNF350,MED4,TP53RK,SMN1,PSMD12,ZNF771,APOBEC3A_B,SRSF3,SMG7,ZNF713,VEGFA,NCOR1,ZNF492,ZNF223,RORB,U2AF2,SF3A1,GSR,TSEN2,ZNF658,DDX47,NFIA,TAF5,SEH1L,ZSCAN32,H2BC10,NUP88,MED16,PSMB3,RAD51D,TFDP1,QARS1,ZCRB1,MTOR,SRSF6,RIOK3,BRPF3,ZNF676,RPL30,EXOSC7,CSNK2A1,COX6C,AKT1,SRSF4,EPRS1,PGR,PSMD13,NUP93,SSR1,CTNNBL1,APOBEC3B,IARS1,ZNF791,TFAP2A,THOC7,ZNF519,CASP10,BNIP3L,MED13,CHERP,MTREX,ZNF776,NUP133,DNMT3A,SARNP,ZNF616,PSMD6,ZMAT5,ZNF75A,ERBB2,NR3C1,ZFP36,SEM1,WDR77,FANCC,ZNF778,TBL1XR1,ELOA2,MED31,STEAP3,MED10,ZNF460,E2F5,MTERF1,GTF3C2,SUMO1,ATF2,ZNF573,POU2F2,ZNF577,UPF2,RBL1,IMP3,ZNF626,UTP3,EXOSC8,MED27,SRPRA,LSM11,ZNF782,KAT2B,RPL7A,TYW1,PAN3,PSMD5,KIT,ACTB,RPL3,ZNF611,TARS2,TEAD3,GEMIN5,RPP25,MIR4444-1,ZNF732,GTF3C5,PSMA3,TFAP2C,SRRT,EIF2B3,HNRNPC,RPL13,ZNF136,EP300,MED8,PSMB10,ZNF23,GTF2A1,ZNF699,MDM2,EIF4B,PSMB9,HDAC1,CDKN1A,GTF3C4,NUP205,RPL35,NR1H3,NOP56,PPP1R13L,INTS8,IGFBP3,TOPBP1,SAP18,TNFSF13,RPP21,POLR3GL,ZSCAN25,METTL3,HNRNPF,SNRPB2,DDOST,TRNT1,LSM6,ZNF556,SUPT4H1,THOC3,MAP2K6,BRIP1,TEAD1,YWHAB,DDX39A,CTU2,RPL22L1,EIF3D,POU4F1,SNRPC,ELOA3P,POLDIP3,PUS1,KCTD15,ZNF564,YWHAE,ZNF665,MED17,H4C2,ZNF641,MIR1257,ZNF528,ZNF606,TNRC6A,ZNF266,PRKAB1,PSMC4,ZNF560,PRDX1,ELL2,TP53INP1,CHD3,SNRPB,SIRT1,YY1,NOP14,ESRRA,RPA2,RPL18A,SMAD2,PPA2,ZNF597,ZNF700,EZH2,RPS14,RCL1,ZNF682,E2F4,CCNE1,CRADD,TEAD2,HNRNPL,MTERF4,NR1H4,ZNF804B,PHF20,TFAM,RPL23,SEC61A1,NUP54,LAMTOR4,RAD9B,ZNF543,BRCA1,INTS9,PSME1,SMG8,RPLP2,CHTOP,EIF2S1,RPA3,H3C3,RPS15,PRKAG2,ZNF14,IPO8,DCP2,ATM,ADAT2,RBL2,TP73,PRPF3,ZNF331,MTO1,AGO3,ZNF559,AAAS,TRMT61B,UBE2I,SMG5,PLAGL1,ZNF746,NOP58,GTF3C6,RARS2,COX14,ZNF729,DROSHA,RPL31,LAMTOR5,DDX46,DDIT4,ZNF256,AURKA,LSM4,PPP1R13B,ZNF37A,NUP42,COX8A,ZNF773,PRPF4,SNW1,ZIK1,MLLT1,NR2F6,RPL37,ZNF480,EEF1A2,SPCS2,CWC25,RTCB,MAML1,EFTUD2,LAMTOR3,FKBP6,ISG20L2,SUZ12,LARS2,MRM3,CPSF2,GEMIN4,SKIC3,TRMT61A,H2AZ2,CDC73,PRKCD,POLR3C,EDC4,SMYD2,ZNF792,PSMD8,TNFRSF10A,FARSB,H3-3B,RAD1,NCOA1,ZNF706,AURKB,EIF2S2,CLNS1A,INTS1,CNOT9,POLR3A,UTP20,DCAF13,PNRC2,RPS25,RPS11,GTF2F1,PSMC2,GADD45A,MPHOSPH6,ZFP2,PRELID1,ZNF549,HIPK1,BRF2,PML,POLR2K,NCOA2,H4C14,ESRRG,TAF12,ZNF441,PSMF1,TRMT6,ZNF557,SMURF2,ZNF415,NCBP1,ZNF860,KRR1,HNF4A,NUP188,TRMT44,EIF3L,ZNF471,ERCC2,YWHAZ,SNRNP48,RPL36AL,CNOT7,ZNF286A,WDR75,PPM1A,RRP8,EIF3A,ZKSCAN1,PAF1,GARS1,MAPKAPK2,USP2,UBE2D3,SESN3,SEC61A2,ZNF510,WDR4,EARS2,H2BC11,JUN,ZNF334,MEAF6,PLK3,NR1I2,RPL12,ZFP69,RPN1,ZNF707,H2BC5,SKI,ZNF709,PIP4K2C,PRPF8,RPL24,ZNF398,EEF2,GSK3B,ZNF701,CDKN1B,ZNF485,APOBEC1,YWHAQ,GPX2,ZNF267,ZNF320,TP53BP2,CDC40,SMAD7,GCFC2,TAF1A,RNF111,TFIP11,PSMB5,CDK5,NUP37,SNRNP70,GATAD2B,ZNF215,NR2E3,WARS2,ZNF430,BANP,ASZ1,KHSRP,TNPO1,TSC1,CNOT6L,ZNF354C,MARS2,RBBP4,H4C4,RBM22,WBP11,IGF2BP2,NFIC,PSME4,POLR2C,DDX6,PCBP1,H4C5,CDKAL1,KCTD1,ZNF433,HNRNPUL1,PRKAG1,CNOT4,TRMT5,MED6,ZNF12,ZNF790,ZNF586,AIMP1,PIWIL1,POP1,ZIM2,PSMB7,EIF4EBP1,TRMT112,DDX42,TFB1M,RPLP1,DHX37,SARS2,TSC2,CCNE2,UBTF,SSB,ATRIP,POLR1D,NOL6,ZNF799,TFAP2D,ZNF418,ZNF738,PHF5A,DGCR8,HSP90AA1,ZC3H8,CRCP,NUP85,CASP1,RIOK2,ZNF716,H4C11,EIF5B,ZNF70,COX18,PELP1,RABGGTB,EXOSC5,JARID2,RARA,H2AZ1,SNRNP200,LSM5,POU4F2,NOTCH2,ADAR,RPS20,ZNF189,SCO1,UBA52,MAPK11,TRMT10C,AGO2,RTF1,NARS2,HDAC2,RNPC3,YWHAG,BYSL,SNAPC5,EXOSC2,PARP1,ZNF221,TDRD6,EHMT2,TNKS1BP1,SNRPA1,DDX21,MLST8,CHD4,ZNF432,RPRD2,SUPT5H,HNF4G,ZKSCAN8,ESR1,SPCS3,NOTCH4,H2AC7,SRSF10,HUS1,WDR18,SEC61B,LEO1,ELOC,CLP1,IGF2BP3,ZNF619,KDM5B,ZNF569,ZNF583,CCNC,ZNF124,RPL15,MAML3,TP53I3,PPIE,PARN,TDG,H4C8,EEF1D,GTF2B,TOP3A,PRKRA,CDK12,XRN2,PPA1,ZNF333,TFAP2B,EIF2B2,RPL17,AGO1,RAD17,TRMT11,CCNA1,GTF2A2,WARS1,BBC3,NUP58,TGFA,RAN,CCN2,WTAP,TP63,SRSF5,CWC15,PSMB2,MED30,EEF1A1,ZNF664,POLR2E,TSEN15,DNAJC8,RPL38,RPS27A,NFIX,ZNF77,ZNF43,ZFP90,RPL10A,ZNF696,RMI1,PRPF31,ZNF419,CNOT2,ZNF562,ZC3H11A,TSNAX,NOB1,TAF9,DDB2,RFC3,THOC5,TYW3,CNOT1,SESN2,TNFRSF10B,CNOT3,UTP4,ZNF496,H2AJ,NR4A1,THRB,NR1D1,ZNF248,EXO1,RPL37A,ZNF785,H2AC4,ZNF343,TGS1,SF3B5,EXOSC3,ZNF454,AKT2,POLR3H,CPSF3,ELL3,RPS13,RFC5,RBM5,UTP18,CD2BP2,YARS1,APAF1,ZNF708,ZNF143,KAT6A,ZNF552,SAP30L,RPTOR,RPL26,PRCC,SMAD3,NUP62,RPA1,CCNT2,ZNF761,DUS2,RPS29,PIWIL2,SRRM1,LSM8,TFAP2E,GAR1,SMARCD3,NUP153,ZNF71,HNRNPU,ZNF197,MTA3,RPL10L,SRSF9,TBX5,MARS1,RFFL,ZFP28,CCAR1,ZNF212,INTS12,TCEA1,POP7,ZNF233,PTEN,TNFRSF10D,H2BC6,VARS2,NR3C2,SMAD4,SET,ZNF202,PPWD1,COX16,EIF3B,PCNA,WBP4,SRP68,COX6A1,NR2C2AP,CITED4,ZNF667,ZNF655,ZNF677,RPL13A,XRN1,ZNF717,SFN,CASP2,WDR36,HNRNPA0,RMI2,QTRT2,ZNF436,HSPA8,ZNF705D,YEATS4,MEN1,LSM10,FOS,SERPINE1,INTS4,KMT5A,PRPF38A,GEMIN6,CPSF7,EIF2B1,CTU1,NBN,PTBP1,NDC1,ING2,UBB,ZNF440,GTF2E2,PSMC3,PRKAA1,CTDP1,H3C7,CSNK1E,SYF2,CCNH,PLRG1,PIP4K2B,NKX2-5,NAT10,PAIP1,EIF3K,RPS12,NR5A2,SMARCA5,ZNF596,TAF1D,PSMA1,CCNK,H2BC8,SEC61G,NHP2,ZNF300,ZNF702P,POLR3D,MAGOH,ZNF621,DCPS,CARS2,ZNF112,RPL4,SMG6,TSR1,RRAGC,ZNF205,INTS14,ELOA,ZNF500,ZFP69B,NUP210,NSUN6,NUP160,ZNF468,CSTF2T,MLLT3,TRMT10A,THUMPD1,WRN,GATAD2A,ELOA3DP,RPL36,ZNF530,TAF4,EIF4G1,RPL35A,APEH,DDX1,ZNF285,JUNB,ZNF737,ZNF599,NEDD4L,RPS16,TSN,PDCD7,NUP43,ZNF493,MAGOHB,LTV1,ZNF195,RPS15A,CDC5L,ZNF568,AARS1,ZNF567,CSTF3,H4C13,EIF3M,MED7,NRBF2,HSPD1,ZNF750,RPL11,TYW5,MIR943,SLBP,XPO1,DIS3,ZNF257,TPRKB,ZNF839,CWC27,GTF3A,EIF4E,ZNF555,ARID3A,POLR2B,RNF34,NFIB,RGCC,NELFCD,SNRPA,ZNF691,NR2E1,RPS27L,SMG1,ZNF304,SLU7,ZNF79,ZNF426,SF3B2,FANCI,GPI,OSGEP,KRBA1,RPL9,HNRNPH1,APOBEC3H,ZNF214,ZNF222,GLS2,ELAC2,PABPN1,POP4,ZBTB8OS,PPP2R5C,CCNT1,NUP50,EEF1G,TP53,ZNF774,H2BC15,RPL21,PPP2R2A,RUNX2,H2BC3,SKIL,ZNF614,DNA2,CDKN2A,PSMB11,ELL,EIF4H,PAPOLA,H3C11,EXOSC10,RPLP0,ZNF589,ZNF490,PSMB8,DNMT3L,BRD7,HEATR1,ZNF287,PWP2,ZNF547,ELAVL2,LSM1,PRKAG3,MSH2,TP53AIP1,USP39,TDRKH
R-HSA-429958	mRNA decay by 3' to 5' exoribonuclease	0.997510799919799	-0.00249230328946258	17	11	0.00121762231569626	9034	10285	9652,23404,28960,22894,5393,10767,11340,56915,51010,118460,23016	SKIC3,EXOSC2,DCPS,DIS3,EXOSC9,HBS1L,EXOSC8,EXOSC5,EXOSC3,EXOSC6,EXOSC7
R-HSA-72649	Translation initiation complex formation	0.997562038245099	-0.00244093842264538	62	47	0.00520256807615674	9034	10285	8664,6210,6231,6224,6235,10480,27335,6201,1974,6233,6230,6205,6207,8662,8669,6189,6208,6229,6217,6206,3646,6194,8668,51065,6234,6227,8666,1965,8894,1981,8661,3921,6228,6188,6202,6209,8667,8665,728689,7458,6232,6204,51386,6223,1975,1977,26986	EIF3D,RPS15A,RPS26,RPS20,RPS29,EIF3M,EIF3K,RPS7,EIF4A2,RPS27A,RPS25,RPS11,RPS13,EIF3B,EIF3J,RPS3A,RPS14,RPS24,RPS16,RPS12,EIF3E,RPS6,EIF3I,RPS27L,RPS28,RPS21,EIF3G,EIF2S1,EIF2S2,EIF4G1,EIF3A,RPSA,RPS23,RPS3,RPS8,RPS15,EIF3H,EIF3F,EIF3CL,EIF4H,RPS27,RPS10,EIF3L,RPS19,EIF4B,EIF4E,PABPC1
R-HSA-5250913	Positive epigenetic regulation of rRNA expression	0.997739871002067	-0.00226268694439635	108	85	0.00940889971219836	9034	10285	25885,3013,8850,5434,8358,9014,653604,11335,8968,7270,10849,84172,8360,5441,8357,5928,8339,8343,8970,79101,8355,60,8340,64425,8467,8363,3018,126961,8365,8367,8350,2074,8370,8341,94239,8347,8345,8353,5440,8361,8366,7913,121504,8348,2033,8346,8334,3017,3015,8368,3021,55766,221830,3066,10514,53615,8354,3012,2932,4641,9015,8362,128312,8349,57504,3065,8359,8352,54815,9533,10919,8335,51082,23451,9219,1107,723790,100302237,8344,1108,57459,9188,8364,3020,9031	POLR1A,H2AC7,KAT2B,POLR2E,H3C2,TAF1B,H3C13,CBX3,H3C7,TTF1,POLR1G,POLR1B,H4C4,POLR2L,H3C10,RBBP4,H2BC8,H2BC7,H2BC11,TAF1D,H3C8,ACTB,H2BC13,POLR1E,SMARCA5,H4C11,H2BC3,H3C14,H4C8,H4C5,H3C1,ERCC6,H4C14,H2BC15,H2AZ2,H2BC4,H2BC9,H3C6,POLR2K,H4C6,H4C2,DEK,H4C16,H2BC17,EP300,H2BC10,H2AC6,H2BC5,H2AZ1,H4C13,H3-3B,H2AJ,POLR1F,HDAC2,MYBBP1A,MBD3,H3C11,H2AC8,GSK3B,MYO1C,TAF1A,H4C12,H2BC26,H2BC21,MTA3,HDAC1,H4C1,H3C3,GATAD2A,POLR1C,EHMT2,H2AC4,POLR1D,SF3B1,MTA2,CHD3,H2AC19,MIR1281,H2BC6,CHD4,GATAD2B,DDX21,H4C3,H3-3A,BAZ1B
R-HSA-3296197	Hydroxycarboxylic acid-binding receptors	0.998204259575116	-0.00179735469955533	3	1	0.000110692937790569	9034	10285	338442	HCAR2
R-HSA-5624958	ARL13B-mediated ciliary trafficking of INPP5E	0.998204259575116	-0.00179735469955533	3	1	0.000110692937790569	9034	10285	5147	PDE6D
R-HSA-73843	5-Phosphoribose 1-diphosphate biosynthesis	0.998204259575116	-0.00179735469955533	3	1	0.000110692937790569	9034	10285	221823	PRPS1L1
R-HSA-351200	Interconversion of polyamines	0.998204259575116	-0.00179735469955533	3	1	0.000110692937790569	9034	10285	54498	SMOX
R-HSA-180897	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	0.998204259575116	-0.00179735469955533	3	1	0.000110692937790569	9034	10285	291	SLC25A4
R-HSA-73864	RNA Polymerase I Transcription	0.998266368256404	-0.00173513622216698	112	88	0.00974097852557007	9034	10285	8334,8348,8366,121504,5440,8353,8932,2074,8341,8370,3018,126961,8365,8367,64425,5928,8339,79101,8343,7270,84172,8360,9014,653604,8968,902,8358,25885,3013,3020,2965,2967,2071,8344,7343,9219,51082,1107,8359,54700,54815,284119,8349,57504,128312,2068,8362,53615,8354,3017,3015,8368,8346,1022,404672,5595,8361,8347,8345,8350,94239,8363,8340,5441,8357,8970,8355,10849,11335,5434,8850,8364,57459,1108,723790,8352,9533,8335,10919,2968,4331,3065,9015,3012,221830,3066,55766,3021	H2AC6,H2BC17,H4C2,H4C16,POLR2K,H3C6,MBD2,ERCC6,H2BC15,H4C14,H2BC3,H3C14,H4C8,H4C5,POLR1E,RBBP4,H2BC8,TAF1D,H2BC7,TTF1,POLR1B,H4C4,TAF1B,H3C13,H3C7,CCNH,H3C2,POLR1A,H2AC7,H3-3A,GTF2H1,GTF2H3,ERCC3,H2BC6,UBTF,MTA2,POLR1D,CHD3,H4C1,RRN3,GATAD2A,CAVIN1,H2BC21,MTA3,H2BC26,ERCC2,H4C12,MBD3,H3C11,H2BC5,H2AZ1,H4C13,H2BC10,CDK7,GTF2H5,MAPK3,H4C6,H2BC4,H2BC9,H3C1,H2AZ2,H4C11,H2BC13,POLR2L,H3C10,H2BC11,H3C8,POLR1G,CBX3,POLR2E,KAT2B,H4C3,GATAD2B,CHD4,H2AC19,H3C3,POLR1C,H2AC4,EHMT2,GTF2H4,MNAT1,HDAC1,TAF1A,H2AC8,POLR1F,HDAC2,H2AJ,H3-3B
R-HSA-6809371	Formation of the cornified envelope	0.998326826871484	-0.00167457444599111	71	54	0.00597741864069072	9034	10285	8502,353131,3728,353145,25818,1830,353139,823,64065,5493,2125,11187,6705,63036,1829,6707,6701,26085,404203,254910,6699,7062,4014,6700,5045,43847,26239,5652,1824,5046,11005,23581,5317,9333,1832,6704,643394,3713,1041,43849,147409,1475,11202,1823,5318,1825,126638,7051,199834,5266,23254,1828,353137,6768	PKP4,LCE1A,JUP,LCE3E,KLK5,DSG3,LCE2A,CAPN1,PERP,PPL,EVPL,PKP3,SPRR2F,CELA2A,DSG2,SPRR3,SPRR2B,KLK13,SPINK6,LCE5A,SPRR1B,TCHH,LORICRIN,SPRR2A,FURIN,KLK14,LCE2B,PRSS8,DSC2,PCSK6,SPINK5,CASP14,PKP1,TGM5,DSP,SPRR2E,SPINK9,IVL,CDSN,KLK12,DSG4,CSTA,KLK8,DSC1,PKP2,DSC3,RPTN,TGM1,LCE4A,PI3,KAZN,DSG1,LCE1F,ST14
R-HSA-389958	Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding	0.998354526683558	-0.00164682859457942	34	24	0.00265663050697365	9034	10285	112714,5201,22948,60,81027,10694,79861,10575,10574,5204,10576,347733,51807,7280,10376,10693,7278,7277,7846,5203,84790,10382,10381,84617	TUBA3E,PFDN1,CCT5,ACTB,TUBB1,CCT8,TUBAL3,CCT4,CCT7,PFDN5,CCT2,TUBB2B,TUBA8,TUBB2A,TUBA1B,CCT6B,TUBA3C,TUBA4A,TUBA1A,PFDN4,TUBA1C,TUBB4A,TUBB3,TUBB6
R-HSA-389957	Prefoldin mediated transfer of substrate  to CCT/TriC	0.998457128400559	-0.00154406305149022	29	20	0.00221385875581138	9034	10285	7280,22948,5201,60,10693,7278,81027,10694,7277,10575,7846,10574,5203,5204,10576,84790,347733,10381,10382,84617	TUBB2A,CCT5,PFDN1,ACTB,CCT6B,TUBA3C,TUBB1,CCT8,TUBA4A,CCT4,TUBA1A,CCT7,PFDN4,PFDN5,CCT2,TUBA1C,TUBB2B,TUBB3,TUBB4A,TUBB6
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	0.998483334376347	-0.0015178169252003	117	92	0.0101837502767323	9034	10285	6136,23521,6164,6210,6231,7311,6224,6152,6137,6135,10480,6201,6233,6169,6130,8662,6142,6189,6208,6122,6194,4736,6229,3646,6217,6234,51065,6125,8666,1965,6146,8894,6168,6181,6228,8667,8665,6161,6188,6209,6157,6155,9349,6204,6223,116832,51121,11224,6156,26986,1975,1977,8664,6144,200916,6138,6159,6124,6235,9045,1974,27335,8669,6133,6205,6230,6207,6129,6154,6206,25873,6166,8668,6227,6165,6167,3921,1981,8661,6128,6202,728689,6160,6175,6139,6143,6232,7458,51386,6176,140801,6123	RPL12,RPL13A,RPL34,RPS15A,RPS26,UBA52,RPS20,RPL24,RPL13,RPL11,EIF3M,RPS7,RPS27A,RPL38,RPL7A,EIF3B,RPL18A,RPS3A,RPS14,RPL3,RPS6,RPL10A,RPS24,EIF3E,RPS16,RPS28,RPS27L,RPL5,EIF3G,EIF2S1,RPL22,EIF2S2,RPL37A,RPLP2,RPS23,EIF3H,EIF3F,RPL32,RPS3,RPS15,RPL27A,RPL27,RPL23,RPS10,RPS19,RPL39L,RPL26L1,RPL35,RPL30,PABPC1,EIF4B,EIF4E,EIF3D,RPL21,RPL22L1,RPL15,RPL29,RPL4,RPS29,RPL14,EIF4A2,EIF3K,EIF3J,RPL9,RPS11,RPS25,RPS13,RPL7,RPL26,RPS12,RPL36,RPL36AL,EIF3I,RPS21,RPL35A,RPL37,RPSA,EIF4G1,EIF3A,RPL6,RPS8,EIF3CL,RPL31,RPLP0,RPL17,RPL19,RPS27,EIF4H,EIF3L,RPLP1,RPL10L,RPL3L
R-HSA-5250924	B-WICH complex positively regulates rRNA expression	0.998542224154211	-0.00145883943477246	93	72	0.00796989152092097	9034	10285	8350,94239,2074,8370,8341,8365,126961,3018,8367,8361,8347,8353,5440,8345,2033,8348,7913,121504,8366,3017,8368,3015,8346,8334,8850,25885,3013,9014,8968,653604,8358,5434,8339,8357,5441,8355,8970,79101,8343,10849,84172,8360,8363,8467,60,8340,64425,8352,9533,8359,8335,23451,51082,100302237,8344,723790,8364,9031,3020,9188,55766,3021,2932,3012,4641,10514,221830,8354,128312,9015,8362,8349	H3C1,H2AZ2,ERCC6,H4C14,H2BC15,H4C8,H3C14,H2BC3,H4C5,H4C6,H2BC4,H3C6,POLR2K,H2BC9,EP300,H2BC17,DEK,H4C16,H4C2,H2BC5,H4C13,H2AZ1,H2BC10,H2AC6,KAT2B,POLR1A,H2AC7,TAF1B,H3C7,H3C13,H3C2,POLR2E,H2BC8,H3C10,POLR2L,H3C8,H2BC11,TAF1D,H2BC7,POLR1G,POLR1B,H4C4,H4C11,SMARCA5,ACTB,H2BC13,POLR1E,H3C3,POLR1C,H4C1,H2AC4,SF3B1,POLR1D,MIR1281,H2BC6,H2AC19,H4C3,BAZ1B,H3-3A,DDX21,H2AJ,H3-3B,GSK3B,H2AC8,MYO1C,MYBBP1A,POLR1F,H3C11,H2BC26,TAF1A,H4C12,H2BC21
R-HSA-73854	RNA Polymerase I Promoter Clearance	0.998674445328347	-0.00132643399639487	110	86	0.00951959264998893	9034	10285	3020,2965,2967,8344,2071,7343,51082,9219,1107,54700,8359,54815,8349,57504,128312,2068,8362,53615,8354,8334,8348,8366,121504,8353,5440,8932,8341,2074,8370,126961,3018,8365,8367,64425,8339,5928,79101,8343,7270,84172,8360,9014,653604,8968,8358,902,25885,3013,8364,57459,1108,723790,9533,8352,10919,8335,2968,4331,3065,9015,3012,221830,3066,55766,3021,3017,3015,8368,8346,1022,5595,404672,8361,8347,8345,8350,94239,8363,8340,5441,8357,8970,8355,10849,5434,8850	H3-3A,GTF2H1,GTF2H3,H2BC6,ERCC3,UBTF,POLR1D,MTA2,CHD3,RRN3,H4C1,GATAD2A,H2BC21,MTA3,H2BC26,ERCC2,H4C12,MBD3,H3C11,H2AC6,H2BC17,H4C2,H4C16,H3C6,POLR2K,MBD2,H2BC15,ERCC6,H4C14,H3C14,H2BC3,H4C8,H4C5,POLR1E,H2BC8,RBBP4,TAF1D,H2BC7,TTF1,POLR1B,H4C4,TAF1B,H3C13,H3C7,H3C2,CCNH,POLR1A,H2AC7,H4C3,GATAD2B,CHD4,H2AC19,POLR1C,H3C3,EHMT2,H2AC4,GTF2H4,MNAT1,HDAC1,TAF1A,H2AC8,POLR1F,HDAC2,H2AJ,H3-3B,H2BC5,H2AZ1,H4C13,H2BC10,CDK7,MAPK3,GTF2H5,H4C6,H2BC4,H2BC9,H3C1,H2AZ2,H4C11,H2BC13,POLR2L,H3C10,H2BC11,H3C8,POLR1G,POLR2E,KAT2B
R-HSA-6803157	Antimicrobial peptides	0.998888636717664	-0.00111198130444947	97	75	0.00830197033429267	9034	10285	6037,3934,51297,1669,57115,5266,140683,245929,7096,149954,4069,729230,245909,6406,117159,5646,130120,92747,122665,7097,116842,3347,245938,475,1991,6278,1235,128859,140881,6280,1672,1113,644414,3346,140850,55600,5657,613210,114771,417,400830,613211,114770,5068,245908,820,245911,245940,6556,6279,1671,245910,1191,671,920,4057,728358,245928,338324,613209,80341,245913,1511,84659,10578,8993,57119,245930,1670,6039,1667,245915,245927,81623,5320	RNASE3,LCN2,BPIFA1,DEFA4,PGLYRP4,PI3,BPIFA2,DEFB115,TLR1,BPIFB4,LYZ,CCR2,DEFB106A,SEMG1,DCD,PRSS3,REG3G,BPIFB1,RNASE8,TLR2,LEAP2,HTN3,DEFB125,ATOX1,ELANE,S100A7,CCR6,BPIFB6,DEFB129,S100A9,DEFB1,CHGA,DEFB131A,HTN1,DEFB127,ITLN1,PRTN3,DEFB136,PGLYRP3,ART1,DEFB132,DEFB134,PGLYRP2,REG3A,DEFB105A,CAMP,DEFB108B,DEFB130A,SLC11A1,S100A8,DEFA6,DEFB107A,CLU,BPI,CD4,LTF,DEFA1B,DEFB114,S100A7A,DEFB135,BPIFB2,DEFB110,CTSG,RNASE7,GNLY,PGLYRP1,EPPIN,DEFB116,DEFA5,RNASE6,DEFA1,DEFB112,DEFB113,DEFB126,PLA2G2A
R-HSA-1482883	Acyl chain remodeling of DAG and TAG	0.998923206206172	-0.00107737395277657	8	4	0.000442771751162276	9034	10285	80339,57104,84649,11343	PNPLA3,PNPLA2,DGAT2,MGLL
R-HSA-73777	RNA Polymerase I Chain Elongation	0.998925270978996	-0.00107530695635759	91	70	0.00774850564533983	9034	10285	9533,8352,8359,8335,2968,7343,51082,8344,2071,723790,8364,3020,2965,2967,55766,3021,3012,221830,8354,128312,2068,9015,8362,8349,4331,8350,94239,8341,8370,8365,126961,3018,8367,8361,8347,5440,8353,8345,404672,8348,121504,8366,3017,8368,3015,8346,1022,8334,25885,3013,9014,8968,11335,653604,902,8358,5434,8357,8339,5441,8355,79101,8970,8343,10849,84172,8360,8363,8340,64425	POLR1C,H3C3,H4C1,H2AC4,GTF2H4,UBTF,POLR1D,H2BC6,ERCC3,H2AC19,H4C3,H3-3A,GTF2H1,GTF2H3,H2AJ,H3-3B,H2AC8,POLR1F,H3C11,H2BC26,ERCC2,TAF1A,H4C12,H2BC21,MNAT1,H3C1,H2AZ2,H2BC15,H4C14,H4C8,H3C14,H2BC3,H4C5,H4C6,H2BC4,POLR2K,H3C6,H2BC9,GTF2H5,H2BC17,H4C16,H4C2,H2BC5,H4C13,H2AZ1,H2BC10,CDK7,H2AC6,POLR1A,H2AC7,TAF1B,H3C7,CBX3,H3C13,CCNH,H3C2,POLR2E,H3C10,H2BC8,POLR2L,H3C8,TAF1D,H2BC11,H2BC7,POLR1G,POLR1B,H4C4,H4C11,H2BC13,POLR1E
R-HSA-72312	rRNA processing	0.998956924866948	-0.00104361951450545	201	162	0.0179322559220722	9034	10285	6234,51010,6125,51065,6146,6181,10528,6168,79050,6228,79897,25879,51118,6209,27340,6188,6161,83732,25926,705,6155,79922,84916,6157,9349,9277,10199,23016,116832,6223,6204,6156,51121,11224,8780,23404,9136,11102,27341,23521,56915,51202,6136,27043,6210,29960,84135,6164,7311,6224,6231,54931,6135,4809,6137,54881,6152,55759,10885,134430,54913,28987,130916,22984,6169,6233,55781,88745,6201,6130,55813,10556,6142,92856,6208,55178,10171,10607,387338,6189,84946,6122,4736,6194,10799,6217,6229,81875,6166,51077,25873,55623,65083,9790,55127,5822,1453,6227,6167,6165,2091,57050,11340,3921,6128,6202,55272,8602,84128,6160,51504,6143,5394,6139,6175,23160,54555,6232,57647,6176,27042,6123,140801,11103,51106,9724,6144,5393,55651,200916,6138,9692,51602,22803,54433,55720,6159,6124,90459,9045,6235,60528,57418,55226,6133,11056,10200,6207,23517,1454,51096,6205,6230,118460,26168,79707,6129,56902,6154,27292,6206,10438	RPS28,EXOSC3,RPL5,RPS27L,RPL22,RPLP2,NOP56,RPL37A,NOC4L,RPS23,RPP21,DCAF13,UTP11,RPS15,UTP20,RPS3,RPL32,RIOK1,NOL11,BYSL,RPL27,MRM1,UTP4,RPL27A,RPL23,WDR46,MPHOSPH10,EXOSC7,RPL39L,RPS19,RPS10,RPL30,RPL26L1,RPL35,RIOK3,EXOSC2,RRP9,RPP14,RRP7A,RPL13A,EXOSC5,DDX47,RPL12,PELP1,RPS15A,MRM2,UTP15,RPL34,UBA52,RPS20,RPS26,TRMT10C,RPL11,SNU13,RPL13,TEX10,RPL24,WDR12,WDR3,WDR36,RPP25,NOB1,MTERF4,PDCD11,RPL38,RPS27A,RIOK2,RRP36,RPS7,RPL7A,UTP6,RPP30,RPL18A,IMP4,RPS14,MRM3,RCL1,TBL3,NSUN4,RPS3A,LTV1,RPL3,RPL10A,RPS6,RPP40,RPS16,RPS24,ISG20L2,RPL36AL,FCF1,RPL36,THUMPD1,NOL6,BMS1,HEATR1,PWP2,CSNK1D,RPS21,RPL37,RPL35A,FBL,UTP3,EXOSC8,RPSA,RPL6,RPS8,IMP3,NOP14,WDR75,RPL31,TRMT112,RPL19,EXOSC10,RPL17,RPLP0,WDR43,DDX49,RPS27,DHX37,RPLP1,UTP25,RPL3L,RPL10L,KRR1,TFB1M,UTP14C,RPL21,EXOSC9,NHP2,RPL22L1,RPL15,PRORP,NOP58,XRN2,GAR1,TSR1,RPL29,RPL4,ERI1,RPL14,RPS29,ELAC2,WDR18,NAT10,RPL9,DDX52,MPHOSPH6,RPS13,MTREX,CSNK1E,UTP18,RPS11,RPS25,EXOSC6,SENP3,NOL9,RPL7,PNO1,RPL26,DIMT1,RPS12,C1D
R-HSA-927802	Nonsense-Mediated Decay (NMD)	0.998979795909308	-0.00102072485310523	120	94	0.0104051361523135	9034	10285	6122,6208,6189,6217,6229,55110,4736,6194,6130,6169,6233,9887,6201,6142,6135,6137,6152,6231,7311,6224,2935,23521,6136,6210,6164,6156,11224,51121,56006,116832,6223,6204,55181,26986,6155,6157,9349,55802,55629,6228,6209,6188,6161,2107,6125,51065,5515,6234,23049,6181,22794,6168,6146,6129,6206,6154,6207,6230,6205,6133,6159,9045,6235,6124,5976,23381,23293,6144,5520,4116,6138,200916,6176,22916,6123,140801,9775,6143,6139,6175,6160,6232,4686,1981,3921,6167,6165,6202,5518,6128,6166,25873,6227,26019	RPL3,RPS14,RPS3A,RPS16,RPS24,MAGOHB,RPL10A,RPS6,RPL7A,RPL38,RPS27A,SMG7,RPS7,RPL18A,RPL11,RPL13,RPL24,RPS26,UBA52,RPS20,GSPT1,RPL13A,RPL12,RPS15A,RPL34,RPL30,RPL35,RPL26L1,SMG9,RPL39L,RPS19,RPS10,SMG8,PABPC1,RPL27,RPL27A,RPL23,DCP1A,PNRC2,RPS23,RPS15,RPS3,RPL32,ETF1,RPL5,RPS27L,PPP2CA,RPS28,SMG1,RPLP2,CASC3,RPL37A,RPL22,RPL7,RPS12,RPL26,RPS13,RPS25,RPS11,RPL9,RPL29,RPL14,RPS29,RPL4,UPF1,SMG5,SMG6,RPL21,PPP2R2A,MAGOH,RPL15,RPL22L1,RPLP1,NCBP2,RPL3L,RPL10L,EIF4A3,RPL19,RPL17,RPLP0,RPL31,RPS27,NCBP1,EIF4G1,RPSA,RPL37,RPL35A,RPS8,PPP2R1A,RPL6,RPL36AL,RPL36,RPS21,UPF2
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	0.998979795909308	-0.00102072485310523	120	94	0.0104051361523135	9034	10285	9045,6235,6124,5976,23381,23293,6159,6138,200916,6144,5520,4116,6206,6154,6129,6207,6230,6205,6133,6202,5518,6128,1981,3921,6167,6165,6227,26019,6166,25873,22916,6123,140801,9775,6176,6232,4686,6143,6175,6139,6160,2935,6135,6137,6152,6224,7311,6231,6210,6164,23521,6136,6217,6229,4736,55110,6194,6122,6208,6189,6142,6130,6169,6233,9887,6201,6209,6188,6161,2107,55629,6228,6181,22794,6168,6146,6125,51065,5515,6234,23049,26986,6156,51121,11224,116832,56006,6223,6204,55181,55802,9349,6155,6157	RPL14,RPS29,RPL4,UPF1,SMG5,SMG6,RPL29,RPL15,RPL22L1,RPL21,PPP2R2A,MAGOH,RPS12,RPL26,RPL7,RPS13,RPS25,RPS11,RPL9,RPS8,PPP2R1A,RPL6,EIF4G1,RPSA,RPL37,RPL35A,RPS21,UPF2,RPL36AL,RPL36,NCBP2,RPL3L,RPL10L,EIF4A3,RPLP1,RPS27,NCBP1,RPL19,RPLP0,RPL17,RPL31,GSPT1,RPL11,RPL13,RPL24,RPS20,UBA52,RPS26,RPS15A,RPL34,RPL13A,RPL12,RPS16,RPS24,RPL10A,MAGOHB,RPS6,RPL3,RPS14,RPS3A,RPL18A,RPL7A,RPL38,RPS27A,SMG7,RPS7,RPS15,RPS3,RPL32,ETF1,PNRC2,RPS23,RPLP2,CASC3,RPL37A,RPL22,RPL5,RPS27L,PPP2CA,RPS28,SMG1,PABPC1,RPL30,RPL26L1,RPL35,RPL39L,SMG9,RPS19,RPS10,SMG8,DCP1A,RPL23,RPL27,RPL27A
R-HSA-391906	Leukotriene receptors	0.999015938459411	-0.000984546047029466	5	2	0.000221385875581138	9034	10285	1241,57105	LTB4R,CYSLTR2
R-HSA-1221632	Meiotic synapsis	0.999033183780887	-0.000967283887370852	79	60	0.00664157626743414	9034	10285	55766,3012,256126,25913,672,128312,8362,4000,8349,10274,8335,7014,8359,11083,4001,8290,8344,9126,10388,723790,8364,27127,26277,7013,3013,23224,8468,545,8970,8343,8339,8360,65057,5885,6847,8363,23353,8340,94239,8341,8370,8367,8365,3018,25777,8361,8345,8347,8348,121504,8366,8368,7329,3015,3017,3306,50511,8334,23345,8346	H2AJ,H2AC8,SYCE2,POT1,BRCA1,H2BC26,H4C12,LMNA,H2BC21,STAG1,H2AC4,TERF2,H4C1,DIDO1,LMNB1,H3-4,H2BC6,SMC3,SYCP2,H2AC19,H4C3,SMC1B,TINF2,TERF1,H2AC7,SYNE2,FKBP6,ATR,H2BC11,H2BC7,H2BC8,H4C4,ACD,RAD21,SYCP1,H4C11,SUN1,H2BC13,H2AZ2,H2BC15,H4C14,H4C5,H4C8,H2BC3,SUN2,H4C6,H2BC9,H2BC4,H2BC17,H4C16,H4C2,H4C13,UBE2I,H2AZ1,H2BC5,HSPA2,SYCP3,H2AC6,SYNE1,H2BC10
R-HSA-8868773	rRNA processing in the nucleus and cytosol	0.999282936474884	-0.000717320738131277	191	153	0.0169360194819571	9034	10285	6232,54555,23160,51504,6160,6175,6139,5394,6143,140801,6123,11103,57647,27042,6176,5822,55127,9790,6227,1453,25873,51077,6166,55623,65083,6128,84128,8602,55272,6202,6165,6167,57050,3921,11340,2091,10200,6133,11056,6205,6230,51096,1454,23517,6207,57418,55226,27292,6154,56902,10438,6206,79707,26168,118460,6129,6138,200916,55651,5393,9724,6144,6124,6235,9045,90459,22803,54433,51602,6159,55720,10199,9277,9349,705,25926,83732,6157,84916,6155,23404,8780,6204,6223,23016,116832,51121,11224,6156,6146,10528,6168,79050,6181,51010,6234,51065,6125,6161,6188,27340,6209,6228,51118,25879,79897,6142,10556,55813,92856,6201,55781,88745,6233,22984,6169,6130,10799,6194,4736,6229,81875,6217,6189,10607,10171,6208,6122,84946,27043,6164,84135,6210,11102,9136,6136,51202,23521,56915,27341,134430,10885,28987,54913,7311,6224,6231,55759,6152,6137,4809,54881,6135	RPS27,DDX49,WDR43,TRMT112,RPL31,RPLP0,RPL17,EXOSC10,RPL19,RPL10L,RPL3L,KRR1,DHX37,UTP25,RPLP1,PWP2,HEATR1,BMS1,RPS21,CSNK1D,RPL36,FCF1,RPL36AL,THUMPD1,NOL6,RPL6,WDR75,NOP14,IMP3,RPS8,RPL35A,RPL37,UTP3,RPSA,EXOSC8,FBL,MPHOSPH6,RPL9,DDX52,RPS11,RPS25,UTP18,CSNK1E,MTREX,RPS13,WDR18,NAT10,DIMT1,RPL26,PNO1,C1D,RPS12,NOL9,SENP3,EXOSC6,RPL7,RPL15,RPL22L1,NHP2,EXOSC9,UTP14C,RPL21,RPL4,RPS29,RPL14,ERI1,XRN2,GAR1,NOP58,RPL29,TSR1,MPHOSPH10,WDR46,RPL23,BYSL,NOL11,RIOK1,RPL27A,UTP4,RPL27,EXOSC2,RIOK3,RPS10,RPS19,EXOSC7,RPL39L,RPL26L1,RPL35,RPL30,RPL22,NOP56,RPL37A,NOC4L,RPLP2,EXOSC3,RPS28,RPS27L,RPL5,RPL32,RPS3,UTP20,RPS15,RPS23,UTP11,DCAF13,RPP21,RPL18A,RPP30,UTP6,IMP4,RPS7,RIOK2,RRP36,RPS27A,PDCD11,RPL38,RPL7A,RPP40,RPS6,RPL10A,RPS24,ISG20L2,RPS16,RPS3A,TBL3,RCL1,RPS14,RPL3,LTV1,PELP1,RPL34,UTP15,RPS15A,RPP14,RRP9,RPL12,DDX47,RPL13A,EXOSC5,RRP7A,WDR36,WDR3,NOB1,RPP25,UBA52,RPS20,RPS26,WDR12,RPL24,RPL13,SNU13,TEX10,RPL11
R-HSA-5619507	Activation of HOX genes during differentiation	0.999543861183325	-0.000456242879631175	126	98	0.0108479079034758	9034	10285	8970,8355,5441,3725,2146,8357,57472,23054,8363,63925,23512,8340,9611,5080,3221,5434,2033,9070,3198,3015,8368,3017,5087,8346,94239,5439,5914,8350,1959,8361,8345,8347,22976,3199,5316,3231,5431,55766,9935,3021,3012,7703,723790,8364,8335,8352,9125,10664,8202,5433,3201,8343,8339,5928,8360,8841,3013,653604,8968,9063,8358,4211,8348,8366,121504,11091,8334,8341,8370,5432,3232,8367,126961,3018,8365,8353,5440,3200,128312,8362,84962,6256,8349,79447,8354,1387,8344,100302237,3020,7528,58508,8726,3211,5929,5915,5430,8359,5916	H2BC11,H3C8,POLR2L,JUN,EZH2,H3C10,CNOT6,NCOA6,H4C11,ZNF335,SUZ12,H2BC13,NCOR1,PAX6,HOXC4,POLR2E,EP300,ASH2L,HOXA1,H2AZ1,H4C13,H2BC5,PBX1,H2BC10,H2AZ2,POLR2J,RARA,H3C1,EGR2,H4C6,H2BC9,H2BC4,PAXIP1,HOXA2,PKNOX1,HOXD1,POLR2B,H2AJ,MAFB,H3-3B,H2AC8,PCGF2,H2AC19,H4C3,H2AC4,H3C3,CNOT9,CTCF,NCOA3,POLR2D,HOXA4,H2BC7,H2BC8,RBBP4,H4C4,HDAC3,H2AC7,H3C13,H3C7,PIAS2,H3C2,MEIS1,H2BC17,H4C2,H4C16,WDR5,H2AC6,H2BC15,H4C14,POLR2C,HOXD3,H4C5,H3C14,H2BC3,H4C8,H3C6,POLR2K,HOXA3,H2BC26,H4C12,AJUBA,RXRA,H2BC21,PAGR1,H3C11,CREBBP,H2BC6,MIR1281,H3-3A,YY1,KMT2C,EED,HOXB1,RBBP5,RARB,POLR2A,H4C1,RARG
R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis	0.999543861183325	-0.000456242879631175	126	98	0.0108479079034758	9034	10285	7703,3012,3021,55766,9935,5431,5316,3231,3199,22976,3201,5433,8202,10664,9125,8352,8335,8364,723790,5434,5080,3221,9611,23512,8340,63925,8363,57472,23054,3725,5441,2146,8357,8970,8355,8347,8345,1959,8361,8350,5914,94239,5439,8346,5087,3017,3015,8368,9070,3198,2033,1387,8354,79447,8349,6256,8362,84962,128312,3200,5916,8359,5430,5915,3211,5929,8726,58508,7528,3020,100302237,8344,9063,8358,653604,8968,3013,8841,8360,8339,5928,8343,5440,8353,126961,3018,8365,8367,3232,8370,8341,5432,8334,11091,8366,121504,8348,4211	PCGF2,H2AC8,H3-3B,H2AJ,MAFB,POLR2B,PKNOX1,HOXD1,HOXA2,PAXIP1,HOXA4,POLR2D,NCOA3,CTCF,CNOT9,H3C3,H2AC4,H4C3,H2AC19,POLR2E,PAX6,HOXC4,NCOR1,SUZ12,H2BC13,ZNF335,H4C11,CNOT6,NCOA6,JUN,POLR2L,EZH2,H3C10,H2BC11,H3C8,H2BC4,H2BC9,EGR2,H4C6,H3C1,RARA,H2AZ2,POLR2J,H2BC10,PBX1,H2BC5,H2AZ1,H4C13,ASH2L,HOXA1,EP300,CREBBP,H3C11,PAGR1,H2BC21,RXRA,H4C12,AJUBA,H2BC26,HOXA3,RARG,H4C1,POLR2A,RARB,HOXB1,RBBP5,EED,KMT2C,YY1,H3-3A,MIR1281,H2BC6,PIAS2,H3C2,H3C13,H3C7,H2AC7,HDAC3,H4C4,H2BC8,RBBP4,H2BC7,POLR2K,H3C6,H3C14,H2BC3,H4C8,H4C5,HOXD3,H4C14,H2BC15,POLR2C,H2AC6,WDR5,H4C2,H4C16,H2BC17,MEIS1
R-HSA-427359	SIRT1 negatively regulates rRNA Expression	0.999582272106888	-0.000417815165713481	69	51	0.00564533982731902	9034	10285	55766,3021,3012,8354,128312,8362,9015,8349,8335,8359,8352,23411,8344,723790,3020,8364,23378,3013,653604,8968,9014,8358,79101,8970,8343,8355,8339,8357,8360,8363,8340,8370,8341,94239,8350,8367,126961,3018,8365,8361,8345,8353,8347,8348,8366,121504,3015,8368,3017,8334,8346	H2AJ,H3-3B,H2AC8,H3C11,H2BC26,H4C12,TAF1A,H2BC21,H2AC4,H4C1,H3C3,SIRT1,H2BC6,H2AC19,H3-3A,H4C3,RRP8,H2AC7,H3C13,H3C7,TAF1B,H3C2,TAF1D,H2BC11,H2BC7,H3C8,H2BC8,H3C10,H4C4,H4C11,H2BC13,H4C14,H2BC15,H2AZ2,H3C1,H4C5,H3C14,H2BC3,H4C8,H4C6,H2BC9,H3C6,H2BC4,H2BC17,H4C2,H4C16,H2AZ1,H4C13,H2BC5,H2AC6,H2BC10
R-HSA-5689603	UCH proteinases	0.999736085786699	-0.000263949044785231	105	80	0.00885543502324552	9034	10285	7311,5692,5699,9491,5700,10197,122706,123228,8334,5684,143471,5710,23198,5713,9958,7979,7316,283899,93973,5715,5682,5717,5706,8332,5711,60,8314,5708,5694,9861,6233,3013,5707,5701,5718,92815,8607,3607,5690,723790,5686,5702,5693,7528,55252,7314,54617,8969,10445,4798,8335,5687,7040,5719,5685,4092,7347,580,221613,86,221656,10213,51377,5696,7345,5720,5704,54891,221937,5698,5695,79913,7046,5714,55777,11047,125476,7048,5691,3012	UBA52,PSMB4,PSMB10,PSMF1,PSMC1,PSME3,PSMB11,SENP8,H2AC6,PSMA3,PSMA8,PSMD4,PSME4,PSMD7,USP15,SEM1,UBC,INO80E,ACTR8,PSMD9,PSMA1,PSMD11,PSMC6,H2AC16,PSMD5,ACTB,BAP1,PSMD2,PSMB6,PSMD6,RPS27A,H2AC7,PSMD1,PSMC2,PSMD12,H2AC25,RUVBL1,FOXK2,PSMB2,H2AC19,PSMA5,PSMC3,PSMB5,YY1,ASXL2,UBB,INO80,H2AC11,MCRS1,NFRKB,H2AC4,PSMA6,TGFB1,PSMD13,PSMA4,SMAD7,UCHL3,BARD1,H2AC1,ACTL6A,KDM1B,PSMD14,UCHL5,PSMB8,UCHL1,PSME1,PSMC4,INO80D,FOXK1,PSMB9,PSMB7,ACTR5,TGFBR1,PSMD8,MBD5,ADRM1,INO80C,TGFBR2,PSMB3,H2AC8
R-HSA-1500620	Meiosis	0.999779881507547	-0.000220142722084372	121	93	0.0102944432145229	9034	10285	4361,6847,10111,8360,6117,8343,84057,8339,8358,8968,545,653604,3013,5888,7156,3306,8334,50511,1017,7329,121504,8366,8348,8353,25777,8367,8365,3018,126961,8370,8341,8349,8362,4000,128312,8354,256126,56979,26277,3020,10388,8344,8290,5889,11083,10274,8359,23353,4292,8340,5885,8363,65057,8355,8970,8357,6118,11144,23224,8468,7013,23345,8346,56154,8368,3015,3017,8345,8347,27030,8361,94239,8350,672,25913,1019,3012,3021,55766,641,8364,27127,9126,472,723790,675,4438,4001,4683,6119,8335,8352,7014	MRE11,SYCP1,RAD50,H4C4,RPA1,H2BC7,MND1,H2BC8,H3C2,H3C7,ATR,H3C13,H2AC7,RAD51,TOP3A,HSPA2,H2AC6,SYCP3,CDK2,UBE2I,H4C16,H4C2,H2BC17,H3C6,SUN2,H4C5,H4C8,H2BC3,H3C14,H4C14,H2BC15,H2BC21,H4C12,LMNA,H2BC26,H3C11,SYCE2,PRDM9,TINF2,H3-3A,SYCP2,H2BC6,H3-4,RAD51C,DIDO1,STAG1,H4C1,SUN1,MLH1,H2BC13,RAD21,H4C11,ACD,H3C8,H2BC11,H3C10,RPA2,DMC1,SYNE2,FKBP6,TERF1,SYNE1,H2BC10,TEX15,H4C13,H2AZ1,H2BC5,H2BC9,H2BC4,MLH3,H4C6,H2AZ2,H3C1,BRCA1,POT1,CDK4,H2AC8,H3-3B,H2AJ,BLM,H4C3,SMC1B,SMC3,ATM,H2AC19,BRCA2,MSH4,LMNB1,NBN,RPA3,H2AC4,H3C3,TERF2
R-HSA-140179	Amine Oxidase reactions	0.999782038126873	-0.00021798563026787	4	1	0.000110692937790569	9034	10285	54498	SMOX
R-HSA-176034	Interactions of Tat with host cellular proteins	0.999782038126873	-0.00021798563026787	4	1	0.000110692937790569	9034	10285	904	CCNT1
R-HSA-804914	Transport of fatty acids	0.999927921700277	-7.20808974880027e-05	8	3	0.000332078813371707	9034	10285	28965,376497,10999	SLC27A6,SLC27A1,SLC27A4
R-HSA-73856	RNA Polymerase II Transcription Termination	0.999931160954375	-6.88414151405494e-05	71	51	0.00564533982731902	9034	10285	22794,6429,26097,79869,6628,6430,10569,55339,80145,51692,9984,4686,10914,10898,9295,84967,6431,22916,9775,8683,23283,51362,7307,53981,10212,51585,6635,6637,9877,10189,84271,4116,84248,1479,81608,6432,10250,6636,7884,8563,134353,6426,8189,84324,84321,8106,6428,25888,10978,55110,11338	CASC3,SRSF4,CHTOP,CPSF7,SNRPB,SRSF5,SLU7,WDR33,THOC7,CPSF3,THOC1,NCBP1,PAPOLA,CPSF4,SRSF11,LSM10,SRSF6,NCBP2,EIF4A3,SRSF9,CSTF2T,CDC40,U2AF1,CPSF2,DDX39A,PCF11,SNRPE,SNRPG,ZC3H11A,ALYREF,POLDIP3,MAGOH,FYTTD1,CSTF3,FIP1L1,SRSF7,SRRM1,SNRPF,SLBP,THOC5,LSM11,SRSF1,SYMPK,SARNP,THOC3,PABPN1,SRSF3,ZNF473,CLP1,MAGOHB,U2AF2
R-HSA-109688	Cleavage of Growing Transcript in the Termination Region	0.999931160954375	-6.88414151405494e-05	71	51	0.00564533982731902	9034	10285	51362,23283,8683,9775,22916,6431,84967,9295,10898,10914,4686,9984,51692,80145,55339,10569,6430,6628,79869,26097,6429,22794,11338,55110,25888,10978,6428,8106,84321,84324,8189,6426,134353,8563,7884,6636,10250,6432,81608,84248,4116,84271,1479,9877,10189,6637,51585,6635,10212,53981,7307	CDC40,CSTF2T,SRSF9,EIF4A3,NCBP2,SRSF6,LSM10,SRSF11,CPSF4,PAPOLA,NCBP1,THOC1,CPSF3,THOC7,WDR33,SLU7,SRSF5,SNRPB,CPSF7,CHTOP,SRSF4,CASC3,U2AF2,MAGOHB,ZNF473,CLP1,SRSF3,PABPN1,THOC3,SARNP,SYMPK,SRSF1,LSM11,THOC5,SLBP,SNRPF,SRRM1,SRSF7,FIP1L1,FYTTD1,MAGOH,POLDIP3,CSTF3,ZC3H11A,ALYREF,SNRPG,PCF11,SNRPE,DDX39A,CPSF2,U2AF1
R-HSA-372790	Signaling by GPCR	0.999956633773133	-4.33671672090469e-05	1299	1097	0.121430152756254	9034	10285	5528,442186,2781,56670,403277,81285,5605,3562,23236,51384,8525,162998,138804,51083,283093,301,219473,1901,2859,2691,6366,5576,6387,56923,7479,1437,9048,5136,3082,5998,26534,27006,390075,391196,7478,346562,5155,7414,2920,5999,26084,81399,2870,23596,2254,81697,5746,155,9181,3375,79295,3351,5529,7450,5693,2774,1020,817,6003,50837,797,283189,26735,1906,26496,685,285659,65055,138881,392392,6754,115,7905,134083,121364,2246,9934,2786,2767,56656,5717,728,11211,2837,23198,5598,143471,5710,2535,119695,8386,79334,6710,219479,594857,2151,165140,2864,6002,2696,5692,5879,1385,3792,8503,5695,54331,109,2520,5623,128674,441608,120776,5536,2532,8698,5037,10563,10203,403274,26538,1950,5245,9542,5153,26212,138802,3356,147,3845,83756,5908,390079,391211,1607,5741,390054,2668,26692,2147,8649,10161,2793,9890,5706,6376,5566,128366,2911,64926,3362,26664,10256,10287,1604,120796,1813,5580,1232,1910,11245,30817,8325,10818,340980,146850,816,5714,7483,135,85397,8322,390181,796,92840,2843,158131,4161,5295,127623,6714,7252,111,1235,9287,6750,1445,53637,4295,80824,2867,8811,26707,5331,259292,3973,5515,387,81050,219982,338442,3718,5726,399473,2834,2916,2335,122740,6846,5701,8323,7482,50839,57486,2250,1849,200734,808,1815,7253,64748,623,2641,145957,259294,2770,3972,6019,170589,80834,390093,2069,151,390190,9491,7410,4987,26245,390038,146,23620,5739,5660,1880,81341,2792,2904,119765,1812,59345,1233,1848,120793,10000,5293,6869,8392,353299,119679,3269,3363,6915,9628,5686,79948,26693,6352,259287,390195,4543,196883,390437,5707,5567,7225,26188,9630,391114,5534,6865,3627,254783,3265,5142,2771,403278,408,50834,718,25780,2251,2798,341416,9475,3354,23538,7074,256148,5700,6370,390058,390191,8074,2065,8643,8660,10692,5732,390323,50865,135948,818,143503,401667,23263,60675,2784,219968,5720,154,2244,129521,100847012,64096,390321,403284,5727,128371,283160,10874,9693,2848,128360,338662,10846,7222,80326,727,5733,390326,3690,5581,53358,2917,115727,285601,5519,9826,403282,79544,406974,6863,441933,5744,4986,284383,403244,1524,83551,114,338755,390199,3579,441911,2776,1843,26184,148,5143,5330,4889,254786,57731,6751,79310,10681,54429,391112,729759,6364,8817,5687,4160,5894,2861,79290,2357,5518,6469,10316,117579,126370,286362,127385,50838,5364,10142,2829,1268,25791,2150,6360,4684,8826,6343,6711,219959,2906,885,134864,5711,441669,3815,403239,51738,392309,183,10718,9034,5367,132112,5137,4993,150,152559,3062,4902,5028,2831,284433,3640,351,10850,26648,389337,5684,5577,5595,1394,2492,5699,390154,26575,5029,53829,7976,152,4922,388,4747,2914,5698,6655,26529,391189,7432,10213,7473,219874,219956,343169,1133,1269,2853,221955,5031,338557,9462,26333,130075,5747,729966,5922,134,51052,59340,4763,57113,2247,10768,9846,4923,2787,6608,3709,441670,56477,7433,1907,8622,126541,347169,8490,26539,5525,4995,151306,84539,7529,4159,1241,442191,55701,2852,5159,1132,5995,2675,160851,7984,7349,391,7472,112,10817,998,5724,2263,2780,5923,10197,8387,57105,10911,1956,6195,8315,150681,390063,6374,5704,10156,3350,7475,5170,3568,553,3708,3357,187,221002,1606,4992,2921,2550,1742,4158,81696,5530,390445,8383,5718,2768,8526,3549,1609,117,27199,6453,259290,259286,84078,2693,83597,153,27115,6870,10268,286365,57580,122876,81061,11251,1903,7852,64106,445328,81392,125963,2783,2260,431704,4254,121129,84904,5575,2243,5021,2838,5691,64407,120787,128272,7855,113091,5156,6001,84033,27237,221035,8437,11221,25759,207,3674,8787,54361,254973,441932,51308,3060,283159,1608,4544,5719,2769,119774,5173,5533,346528,9290,5745,26476,259289,390439,390429,26740,26219,6363,5573,55160,390168,26166,3667,9568,9861,10235,401665,3352,390327,5527,143502,119772,2064,390265,10887,1844,390261,7979,5997,88,8477,2695,219484,7204,5144,552,122706,4893,26246,5532,90226,339403,259285,257313,390197,8831,80346,390433,122042,2692,5499,5151,29,1439,7477,5696,1902,390084,2826,157,3355,122742,5734,51289,747,51332,815,50649,2782,390431,5786,136,319100,113,26689,7474,219960,119682,673,2854,6375,9828,1889,1894,390067,50833,2791,50831,4988,390442,114131,57406,9978,128368,64108,8326,26341,2913,2778,10266,5737,116,133,4886,58191,1325,89780,4994,26230,5296,219875,1236,163404,10663,389090,3576,1393,5140,2779,7200,219873,2841,4140,2642,10803,729230,219952,6010,390155,7314,6344,80835,11250,7481,2885,2674,219957,4296,5516,5702,2587,6372,1847,84634,1816,5588,504191,50846,6654,442194,1392,2915,2869,5332,5682,9294,11343,219954,9138,26248,79541,59350,341152,89846,6373,219436,8321,5540,119678,846,94233,2796,125958,84109,55970,3814,156,5291,2264,23533,5924,391109,3710,3361,50832,2912,1395,441639,84658,283365,5594,121275,26658,108,3717,392390,5685,7434,393046,390064,2488,3274,2149,390036,9288,2253,2359,347148,6866,221472,6233,2918,341418,5694,2773,121512,8682,2862,9718,341568,138803,6752,5880,2015,10276,10888,5443,4233,4887,28956,138805,5321,3559,344892,9365,94235,27040,551,3577,54756,64805,391192,1081,6755,2066,27202,3558,100271715,1237,2919,3360,9038,8874,2865,5290,138882,26090,392391,389,1230,1846,5582,2358,2534,119692,26493,504189,79473,208,390077,8111,387129,9340,7010,256933,219453,5154,10048,283455,338398,26492,6708,6357,5568,115557,5708,282775,5729,3084,135941,26659,2790,346517,84152,5583,886,4314,222545,10267,8390,57449,2797,10125,611,5731,10672,2255,219965,4985,284,976,814,7480,343406,2252,5604,9639,122748,79317,283092,196335,403273,2863,9283,7201,5141,6709,50835,3827,801,26737,6753,2847,10451,219870,23365,3716,390275,26533,2905,409,283162,1908,8601,26696,10636,719,2922,81470,4991,2788,8527,2266,1128,2248,2740,5179,283111,8388,390260,7484,5713,53831,8997,341799,153090,255725,219858,805,144124,338675,140,5539,10022,7311,390271,50940,401994,10886,26281,57121,135924,3560,1814,54518,7471,5979,8452,81442,1131,4829,219958,8484,26686,1909,5150,259296,185,8822,51764,4157,8786,23370,2249,1850,5906,221391,1129,219986,799,3567,392376,23566,5020,81127,1234,161742,8590,2261,5294,5921,9162,5526,9965,5032,887,219981,5715,84292,6346,7316,11214,6368,5578,26595,259295,5996,219983,2676,5368,5138,2903,5196,1839,121130,347168,57007,5579,401992,7476,5697,107,7932,2832,5139,50650,624,6464,6196,3061,138799,8324,26339,643,29933,22899,7409,11255,6712,54886,124538,4852,6000,6288,51554,5690	PPP2R5D,OR2J3,GNAZ,SUCNR1,OR5K3,OR51E2,MAP2K2,IL3,PLCB1,WNT16,DGKZ,OR7D2,OR13C4,GAL,OR4C12,ANXA1,OR8K3,S1PR1,GPR35,GHRH,CCL21,PRKAR2A,CXCL12,NMUR2,WNT8B,CSF2,ARTN,PDE1A,HGF,RGS3,OR10G2,FGF22,OR52N5,OR2M7,WNT8A,GNAT3,PDGFB,VCL,CXCL2,RGS4,ARHGEF26,OR4F16,GRK6,OPN3,FGF9,OR2B2,PTH2R,ADRB3,ARHGEF2,IAPP,OR5H6,HTR1B,PPP2R5E,VWF,PSMB5,GNAL,CDK5,CAMK2D,RGS13,TAS2R7,CALCB,OR9G4,OR1L3,EDN1,OR10A3,BTC,OR2V2,REEP1,OR1L8,OR1K1,SSTR4,ADCY9,REEP5,OR2Y1,OR10A7,FGF1,P2RY14,GNG4,GNA11,OR2S2,PSMD11,C5AR1,FZD10,UTS2R,PSME4,MAPK7,PSMA8,PSMD4,FZD2,OR52R1,OR1D5,OR11H2,SPTB,OR8U3,NPS,F2RL2,OXER1,FFAR1,RGS12,GIPR,PSMB4,RAC1,CREB1,KEL,PIK3R3,PSMB7,GNG2,ADCY3,GAST,PSPN,PROKR2,OR5B3,OR2D2,PPP5C,ACKR1,S1PR4,PEBP1,CXCL13,CALCRL,OR5H15,OR10H2,EGF,PHB1,NRG2,PDE1B,OR2B6,OR13C8,HTR2A,ADRA1B,KRAS,TAS1R3,RAP1B,OR52E8,OR2G6,DGKB,PTH,OR52A5,GDNF,OR2W1,F2,LAMTOR3,LPAR6,GNGT2,PLPPR4,PSMC6,CX3CL1,PRKACA,OR6P1,GRM1,RASAL3,HTR6,OR7C1,CNKSR1,RGS19,CD55,OR56A1,DRD2,PRKCD,CCR3,EDNRB,GPR176,ADGRE2,FZD8,FRS2,OR52B6,PIK3R6,CAMK2B,PSMD8,WNT9A,ADORA2A,RGS8,FZD4,OR5AK2,CALCA,REEP6,GPR20,OR1Q1,MC5R,PIK3R1,OR2B11,SRC,TSHB,ADCY5,CCR6,TAAR2,SST,CSK,S1PR5,MLN,DUSP16,FFAR2,GALR2,OR2J2,PLCB3,TAS2R46,LHCGR,PPP2CA,RHOA,OR5AC2,OR5A1,HCAR2,JAK3,TAS2R38,SPRED3,PRLHR,GRM6,FN1,OR4K14,XCL2,PSMC2,FZD6,WNT2B,TAS2R10,NLN,FGF5,DUSP7,SPRED2,CALM3,DRD4,TSHR,PLPPR2,BDKRB1,GCG,NRG4,TAS2R19,GNAI1,LHB,RLN2,GPHA2,TAS1R2,OR10A6,EREG,ADRA2B,OR5B2,PSMF1,VAV2,OPRL1,OR2M4,OR51D1,ADRA1D,NTSR2,PTGIR,PSAP,GPR183,OR10W1,GNGT1,GRIN2B,OR4B1,DRD1,GNB4,CCR4,DUSP6,OR56A4,AKT3,PIK3CD,TACR1,OR3A3,RGSL1,OR52J3,HRH1,HTR7,TBXA2R,RGS6,PSMA5,PLPPR3,OR2V1,CCL5,TAS2R41,OR5AN1,MTNR1A,ADCY4,OR4N5,PSMD1,PRKACB,TRPC6,OR1C1,GNA14,OR6K3,PPP3R1,TACR2,CXCL10,OR6C74,HRAS,PDE4B,GNAI2,OR5K4,ARRB1,TAS2R1,C3,RASGRP3,FGF6,GNRHR,OR6C2,ROCK2,HTR1E,OR52A1,TIAM1,OR4S1,PSMC1,CCL25,OR51B6,OR5B12,FGF23,ERBB3,PTCH2,IRS2,RRH,PTGER2,OR6C75,HEBP1,OR2F2,CAMK2G,OR51E1,OR51A2,MCF2L,PROK2,GNB3,OR5B21,PSME1,ADRB2,FGB,NMS,MIR5004,GFRA4,OR6C1,OR6C68,PTCH1,OR6K6,OR8D2,NMU,RAPGEF2,GPR25,OR10T2,OR8D4,PDE10A,TRPC3,WNT10A,C5,PTGER3,OR6C76,ITGB3,PRKCE,SHC3,GRM7,RASGRP4,GPR150,PPP2R1B,ARHGEF11,OR6C65,OR4K1,MIR197,TAC1,OR13G1,PTHLH,OPRK1,OR2Z1,OR2T35,CX3CR1,TAAR8,ADCY8,OR2AG2,OR4D9,CXCR2,OR10J3,GNAQ,DUSP1,OR1F2P,ADRA1A,PDE4C,PLCB2,NPY5R,OR6C3,SPTBN4,SSTR1,OR5H2,GNB5,TAS2R5,OR6Y1,OR4F29,CCL20,FGF18,PSMA6,MC4R,RAF1,GPR37,OR13A1,FPR1,PPP2R1A,SHH,NMUR1,RLN3,OR1I1,OR13C9,OR10J5,TAS2R13,PLXNB1,AKAP9,XCR1,CNR1,NGEF,F2RL1,CCL16,NCAM1,IQGAP1,SCT,SPTBN1,OR1S1,GRIN2D,CCK,TAAR1,PSMD5,OR4Q3,KIT,OR2T27,GHRL,OR13J1,AGT,NRG3,CCRL2,PMCH,RTP1,PDE1C,OR2C1,ADRA2A,PAQR3,HCRTR2,NRTN,P2RY1,NPBWR1,OR10H5,INSL3,APP,CCL27,OR7E24,ARHGEF37,PSMA3,PRKAR2B,MAPK3,CRHR1,FSHR,PSMB10,OR5T3,RGS17,P2RY2,P2RY13,FZD3,ADRA2C,NTS,RHOB,NEFL,GRM4,PSMB9,SOS2,OR12D2,OR11L1,VIP,PSMD14,WNT3,OR6T1,OR9Q1,OR6F1,CHRM5,CNR2,GPR31,DAGLB,P2RY6,FFAR4,RASAL2,OR7A17,OR9A4,PTK2,CIST1,RASA2,ADORA1,PRLH,HRH4,NF1,TRPC7,FGF2,AHCYL1,GAB2,NTSR1,GNG5,SMO,ITPR2,OR4M1,CCL28,VIPR1,EDN2,PDE8B,OR10H4,OR1B1,RGS5,OR10H1,PPP2R5A,OR3A2,GPBAR1,MCHR2,YWHAB,MC3R,LTB4R,OR14J1,ARHGEF40,GPER1,PDGFRB,CHRM4,RGR,GFRA2,DGKH,ARHGEF5,UCN,RHOG,WNT2,ADCY6,FRS3,CDC42,PTAFR,FGFR2,GNAT2,RASGRF1,PSME3,OR1E1,CYSLTR2,UTS2,EGFR,RPS6KA1,BRAP,OR6B3,OR51I1,CXCL5,PSMC4,RASA4,HTR1A,WNT6,PDPK1,IL5RA,AVPR1B,ITPR1,HTR2B,APLNR,RASGEF1A,DGKA,OR1F1,CXCL3,GABBR1,DLG4,MC2R,OR5V1,PPP3CA,OR5AU1,OR1A1,PSMD12,GNA12,DGKE,IHH,DGKQ,ADCYAP1R1,OXGR1,ITSN1,TAS2R31,TAS2R40,KBTBD7,GHSR,RTP3,ADRB1,PDE7B,TACR3,RAMP3,OR13D1,PREX1,GPHB5,OR11H1,PTGDR2,S1PR3,CXCR4,NPFFR1,ARHGEF35,OR2AE1,OR1M1,GNB2,FGFR1,RGS21,KITLG,OR2AP1,ARHGEF39,PRKAR1B,FGA,OXTR,GPR15,PSMB3,RGS18,OR52W1,ARHGEF19,FZD5,PTH2,PDGFRA,RGS10,OBSCN,ARHGEF16,REEP3,RASAL1,DUSP10,SHC2,AKT1,ITGA2B,RGS9,WNT4,OR1L4,OR2W5P,REEP2,HCRT,OR8D1,DGKG,MTNR1B,PSMD13,GNA15,OR52K2,PDYN,PPP3CC,OR2A1,GPR55,PTH1R,OR10J1,TAS2R43,OR11G2,OR4N2,OR1J2,OR1J4,CCL19,PRKAR1A,ARHGEF10L,OR5M1,RGS22,IRS1,GABBR2,PSMD6,RASGRP2,OR51T1,HTR1D,OR6C70,PPP2R5C,OR52I2,OR52M1,ERBB2,OR10G7,PROKR1,DUSP2,OR6M1,SEM1,RGS2,ACTN2,GPR65,GIP,OR5M8,TRIO,PDE4D,AVPR1A,PSMB11,NRAS,OR2L2,PPP3CB,UCN2,RXFP4,TAS2R39,UTS2B,OR4D10,SYNGAP1,REEP4,OR4K13,RXFP2,GHRHR,PPP1CA,PDE8A,ABR,CSF2RB,WNT7B,PSMB8,LPAR1,OR56A5,CCR10,GRK3,HTR1F,OR4L1,PTGER4,RXFP3,DAGLA,SPTBN5,CAMK2A,ARHGEF4,GNB1,OR4K2,PTPRA,ADORA2B,TAAR6,ADCY7,OR4D1,WNT5A,OR10Q1,OR51L1,BRAF,GPR32,XCL1,ARHGEF17,ECE1,ECT2,OR52H1,TAS2R16,GNG11,TAS2R3,OPRM1,OR11H4,UCN3,ABHD6,RBX1,OR10Z1,RTP4,FZD9,OR5H1,GRM3,GNAS,RAMP2,PTGFR,ADCYAP1,ADM,NPY1R,CXCL16,CORT,WNT3A,OR3A1,TIAM2,PIK3R2,OR4D5,CCR7,PLPPR5,CXCR6,OR6B2,CXCL8,CRHBP,PDE3B,GNAT1,TRH,OR10S1,GPR18,MARK3,GCGR,CCR9,CCR2,OR6Q1,RHO,OR5T1,UBB,SCTR,TAS1R1,GPR45,WNT11,GRB2,GFRA1,OR9Q2,MAP3K11,PPP2CB,PSMC3,GALR1,CXCL6,DUSP5,KISS1R,DRD5,PRKCQ,OR9G9,DHH,SOS1,OR10C1,CRH,GRM5,GRK5,PLCB4,PSMA1,S1PR2,MGLL,OR9I1,ARHGEF1,OR2K2,OR2A4,RXFP1,OR2AT4,FGD3,CXCL11,OR5D14,FZD1,NPY4R,OR52E2,CASR,OPN4,GNRH1,OR7D4,QRFPR,GNG12,KISS1,GRK2,PIK3CB,FGFR4,PIK3R5,RASGRF2,OR10K1,ITPR3,HTR5A,TAS2R4,GRM2,CRHR2,OR9K2,ADGRE3,OR6C6,MAPK1,OR10AD1,OR7C2,ADCY2,JAK2,OR1L6,PSMA4,VIPR2,OR2A5,OR51I2,FSHB,HRH2,F2R,OR52K1,TAAR3P,FGF8,FPR3,QRFP,TAC3,FGD2,RPS27A,GRM8,OR6C4,PSMB6,GNAI3,FGD4,PEA15,MLNR,ECE2,OR8S1,OR13C3,SSTR2,RAC2,ADGRE1,NET1,GPR83,POMC,MET,NPY2R,LAMTOR2,OR13F1,PLA2G4A,IL2RA,RTP2,KL,GNG8,LAT,AVP,CXCR1,IL17RD,P2RY12,OR2L3,CGA,SSTR5,ERBB4,C5AR2,IL2,ARHGEF33,CCR8,CXCL1,HTR4,TAAR5,ARHGEF7,FFAR3,PIK3CA,OR1N2,ABHD12,OR5C1,RHOC,CCR1,DUSP4,PRKCG,FPR2,FYN,OR51S1,OR8B8,OR8U8,OR52N1,AKT2,OR52N2,GPR68,NPSR1,GLP2R,TEK,NPB,OR8K5,PDGFA,RANBP9,KSR2,TAS2R60,OR8G2P,SPTA1,CCL13,PRKACG,ARHGEF25,PSMD2,OR5J2,PTGDR,NRG1,OR2A14,OR7A5,GNG10,OR6V1,PPP1R1B,PRKCH,CCKAR,MMP3,GPRC6A,RAMP1,OR1G1,PLEKHG5,GNRH2,RASGRP1,OPN1SW,PTGER1,GNA13,FGF10,OR5B17,OPRD1,ANGPT1,ADGRE5,CAMK4,WNT10B,OR10R2,FGF7,MAP2K1,ARHGEF10,OR11H6,OR4K5,OR4C13,OR56B4,OR5H14,GPR39,GPR37L1,TRHR,PDE4A,SPTAN1,TAS2R9,KNG1,CALM1,OR1L1,SSTR3,MCHR1,VAV3,OR10G9,ARHGEF12,JAK1,OR8A1,OR10G3,GRIN2C,ARRB2,OR8B4,EDN3,RGS20,OR2T1,RGS14,C3AR1,GRP,OR2G2,OR1D2,GNG7,DGKD,FGG,CHRM1,FGF3,GLP1R,PENK,OR51V1,OR1E2,OR6X1,WNT9B,PSMD7,GPR84,KALRN,OR6S1,DAB2IP,OR52B2,OR8B12,CALM2,OR10A5,OR5AP2,ADORA3,PPY,INSL5,UBA52,OR8B3,PDE11A,OR14I1,NPFFR2,FGF20,LPAR5,OR9A2,IL2RB,DRD3,APBB1IP,WNT1,RET,CUL3,OR6N2,CHRM3,NMBR,OR1S2,GALR3,OR4E2,EDNRA,PDE7A,TAS2R50,AGTR1,FGF17,GNG13,MC1R,RGS11,ARHGEF18,FGF4,DUSP8,RAP1A,OPN5,CHRM2,OR4D11,CALCR,IL5,OR13C2,LPAR3,OXT,OR4K15,CCR5,SPRED1,OR6A2,FGFR3,PIK3CG,RASA1,DGKI,PPP2R5B,FGF19,P2RY11,CCKBR,OR5A2,PSMD9,WDR83,CCL1,UBC,AKAP13,CCL23,PRKCA,OR8B2,TAS2R20,RGS1,OR4D6,GFRA3,PNOC,PDE2A,GRIN2A,PF4,HBEGF,OR10P1,OR1J1,ACKR3,PRKCB,OR2T2,WNT7A,PYY,ADCY1,OR2H2,NPBWR2,PDE3A,ARHGEF3,BDKRB2,SHC1,RPS6KA2,HCRTR1,OR13C5,FZD7,OR5K1,CXCR5,GPR132,ARHGEF15,VAV1,HRH3,SPTBN2,PLPPR1,OR4D2,NPY,RGS7,SAA1,ACKR4,PSMB2
R-HSA-1663150	The activation of arylsulfatases	0.999965706018277	-3.42945697746067e-05	13	6	0.000664157626743414	9034	10285	79642,285362,411,340075,153642,22901	ARSJ,SUMF1,ARSB,ARSI,ARSK,ARSG
R-HSA-73857	RNA Polymerase II Transcription	0.99997329184567	-2.67085109995436e-05	159	122	0.0135045384104494	9034	10285	2968,51497,6429,22794,5433,26097,79869,2961,6882,80145,6829,51692,9646,9150,55339,10569,2963,84967,6431,2957,9984,9295,10898,23168,51362,83860,138474,4331,5431,10189,9877,5439,6875,1479,6877,79577,81608,53981,7307,6635,6637,404672,6880,7884,8731,100126332,8563,55840,1022,6636,6428,134353,5434,100302242,5441,7469,11338,55110,6628,5430,6917,100506888,27125,54623,4298,2071,6874,55677,6430,11198,2965,2967,100302168,8178,6924,4686,8732,2960,10914,23283,4300,8683,2068,2958,6879,22916,9775,6884,162699,5432,51224,85403,84271,84248,4116,10212,6923,905,51585,5440,2959,6432,7936,10250,6883,8189,84324,84321,6827,8106,6426,902,2962,6881,904,8812,6749,6873,25888,10978,123169,6921	GTF2H4,NELFCD,SRSF4,CASC3,POLR2D,CHTOP,CPSF7,GTF2E2,TAF11,THOC7,SUPT5H,CPSF3,CTR9,CTDP1,WDR33,SLU7,GTF2F2,LSM10,SRSF6,GTF2A1,THOC1,SRSF11,CPSF4,RTF1,CDC40,TAF3,TAF1L,MNAT1,POLR2B,ALYREF,ZC3H11A,POLR2J,TAF4B,CSTF3,TAF5,CDC73,FIP1L1,CPSF2,U2AF1,SNRPE,SNRPG,GTF2H5,TAF9,SLBP,RNMT,MIR943,THOC5,EAF2,CDK7,SNRPF,SRSF3,LSM11,POLR2E,MIR1236,POLR2L,NELFA,U2AF2,MAGOHB,SNRPB,POLR2A,TCEA1,ELOA3DP,AFF4,PAF1,MLLT1,ERCC3,TAF4,IWS1,SRSF5,SUPT16H,GTF2H1,GTF2H3,MIR1257,ELL,ELOA,NCBP1,RNGTT,GTF2E1,PAPOLA,CSTF2T,MLLT3,SRSF9,ERCC2,GTF2A2,TAF7,NCBP2,EIF4A3,TAF13,ELOA3P,POLR2C,ELOA2,EAF1,POLDIP3,FYTTD1,MAGOH,DDX39A,ELOB,CCNT2,PCF11,POLR2K,GTF2B,SRSF7,NELFE,SRRM1,TAF12,SYMPK,SARNP,THOC3,SUPT4H1,PABPN1,SRSF1,CCNH,GTF2F1,TAF10,CCNT1,CCNK,SSRP1,TAF2,ZNF473,CLP1,LEO1,ELOC
R-HSA-72187	mRNA 3'-end processing	0.999974482599922	-2.55177256524408e-05	62	43	0.00475979632499447	9034	10285	8563,51692,80145,10569,55339,10250,6430,6432,81608,1479,84271,4116,84248,10189,9877,79869,51585,26097,6429,22794,10212,7307,53981,11338,51362,8683,23283,9775,55110,22916,10978,8106,6428,84321,6431,84324,8189,10914,10898,9295,4686,6426,9984	THOC5,CPSF3,THOC7,SLU7,WDR33,SRRM1,SRSF5,SRSF7,FIP1L1,CSTF3,POLDIP3,MAGOH,FYTTD1,ALYREF,ZC3H11A,CPSF7,PCF11,CHTOP,SRSF4,CASC3,DDX39A,U2AF1,CPSF2,U2AF2,CDC40,SRSF9,CSTF2T,EIF4A3,MAGOHB,NCBP2,CLP1,PABPN1,SRSF3,THOC3,SRSF6,SARNP,SYMPK,PAPOLA,CPSF4,SRSF11,NCBP1,SRSF1,THOC1
R-HSA-1461973	Defensins	0.999996248131258	-3.75187577983881e-06	51	33	0.00365286694708878	9034	10285	613211,400830,417,613210,81623,245927,245915,1667,140850,1670,644414,1672,245930,140881,245913,1235,245938,613209,7097,245928,5646,728358,920,245909,729230,245910,245929,7096,1671,245940,245911,245908,1669	DEFB134,DEFB132,ART1,DEFB136,DEFB126,DEFB113,DEFB112,DEFA1,DEFB127,DEFA5,DEFB131A,DEFB1,DEFB116,DEFB129,DEFB110,CCR6,DEFB125,DEFB135,TLR2,DEFB114,PRSS3,DEFA1B,CD4,DEFB106A,CCR2,DEFB107A,DEFB115,TLR1,DEFA6,DEFB130A,DEFB108B,DEFB105A,DEFA4
R-HSA-1461957	Beta defensins	0.999999399727075	-6.00273105317781e-07	42	25	0.00276732344476422	9034	10285	140850,245930,644414,1672,81623,245915,245927,613210,613211,400830,613209,245938,1235,245913,140881,729230,245909,7097,245928,245908,245911,245940,7096,245929,245910	DEFB127,DEFB116,DEFB131A,DEFB1,DEFB126,DEFB112,DEFB113,DEFB136,DEFB134,DEFB132,DEFB135,DEFB125,CCR6,DEFB110,DEFB129,CCR2,DEFB106A,TLR2,DEFB114,DEFB105A,DEFB108B,DEFB130A,TLR1,DEFB115,DEFB107A
R-HSA-5688426	Deubiquitination	0.999999551588406	-4.4841169496783e-07	301	235	0.0260128403807837	9034	10285	6478,7316,10868,9958,8312,57599,9491,8348,10197,7417,3013,79594,10392,9101,23770,9868,5701,6881,4792,2099,92815,5715,5682,8339,5071,93973,23326,6502,54764,5685,55031,8969,3091,10445,10318,63967,5686,100302237,9099,5690,1080,7528,84282,55252,10454,7321,64750,4609,890,78990,11047,7048,8900,128312,580,8678,5704,8349,55611,8975,5713,8347,9577,2033,7311,5699,56957,4194,123228,27005,5684,5423,6885,8850,9097,329,8078,5886,409,7128,4086,5706,57506,10600,219333,5711,60,8314,8340,79155,7040,84101,7314,387,993,84196,57695,84749,5702,9817,7419,114803,723790,55288,8767,8313,23172,51651,4287,57646,3012,5714,8658,221613,7347,10213,27430,100500827,51720,4193,5698,54891,8341,143471,5710,3018,10617,7979,23198,7157,23252,5692,9960,324,122706,8737,64135,8334,330,9986,7415,8607,6314,161725,8343,5717,7416,126119,64426,9861,440689,5708,4088,9929,5687,10254,7706,64127,7375,8344,4089,29086,7189,23358,5728,10474,5695,91833,991,80351,55777,7353,51377,5696,10869,8295,100287144,84132,408,8345,1643,8724,5700,8027,9100,3017,9804,9736,8346,5707,2625,4087,6233,23586,7187,25862,5718,8970,3416,8332,7874,283899,377630,5694,5887,8335,4798,5719,54617,9146,23032,29761,3607,5693,63891,79913,7046,57559,5691,1540,84142,114548,79931,125476,81847,5720,672,154,4092,86,221656,7345,221937,55432,90865	SIAH2,UBC,USP20,USP15,AXIN1,WDR48,PSMF1,H2BC17,PSME3,VDAC2,H2AC7,MUL1,NOD1,USP8,FKBP8,TOMM70,PSMC2,TAF10,NFKBIA,ESR1,H2AC25,PSMD9,PSMA1,H2BC8,PRKN,ACTR8,USP22,SKP2,ZRANB1,PSMA4,USP47,H2AC11,HIF1A,MCRS1,TNIP1,CLSPN,PSMA5,MIR1281,USP2,PSMB2,CFTR,YY1,RNF135,ASXL2,TAB1,UBE2D1,SMURF2,MYC,CCNA2,OTUB2,ADRM1,TGFBR2,CCNA1,H2BC26,BARD1,BECN1,PSMC4,H2BC21,OTUB1,USP13,PSMD7,H2BC4,BABAM2,EP300,UBA52,PSMB10,OTUD7B,MDM4,SENP8,USP21,PSMA3,POLB,MAP3K7,KAT2B,USP14,BIRC2,USP5,RAD23A,ARRB2,TNFAIP3,SMAD1,PSMC6,MAVS,USP16,USP12,PSMD5,ACTB,BAP1,H2BC13,TNIP2,TGFB1,USP44,UBB,RHOA,CDC25A,USP48,USP37,USP30,PSMC3,KEAP1,VDAC3,MYSM1,H2AC19,RHOT1,RIPK2,AXIN2,ABRAXAS2,PTRH2,ATXN3,USP28,H2AC8,PSMD8,TNKS,H2AC1,UCHL3,PSMD14,MAT2B,MIR3614,UIMC1,MDM2,PSMB9,INO80D,H2BC15,PSMA8,PSMD4,H2BC3,STAMBP,SEM1,PSME4,TP53,OTUD3,PSMB4,USP3,APC,PSMB11,RIPK1,IFIH1,H2AC6,BIRC3,RCE1,VCP,RUVBL1,ATXN7,OTUD7A,H2BC7,PSMD11,VDAC1,JOSD2,SUDS3,PSMD6,H2BC18,PSMD2,SMAD3,JOSD1,PSMA6,STAM2,TRIM25,NOD2,USP4,H2BC6,SMAD4,BABAM1,TRAF6,USP24,PTEN,TADA3,PSMB7,WDR20,CDC20,TNKS2,MBD5,UFD1,UCHL5,PSMB8,USP19,TRRAP,USP17L10,USP42,ARRB1,H2BC9,DDB2,SNX3,PSMC1,STAM,USP10,H2BC5,TOMM20,USP34,H2BC10,PSMD1,GATA3,SMAD2,RPS27A,RIGI,TRAF3,USP49,PSMD12,H2BC11,IDE,H2AC16,USP7,INO80E,USP17L2,PSMB6,RAD23B,H2AC4,NFRKB,PSMD13,INO80,HGS,USP33,USP25,FOXK2,PSMB5,RNF123,ACTR5,TGFBR1,STAMBPL1,PSMB3,CYLD,ABRAXAS1,NLRP3,TNIP3,INO80C,RNF146,PSME1,BRCA1,ADRB2,SMAD7,ACTL6A,KDM1B,UCHL1,FOXK1,YOD1,IL33
R-HSA-5689880	Ub-specific processing proteases	0.999999939849975	-6.01500268628186e-08	223	168	0.0185964135488156	9034	10285	3013,79594,330,9986,7417,9101,23770,9868,8607,6314,6881,5701,4792,92815,5715,8343,5682,8339,5717,7416,64426,23326,6502,9861,440689,5708,4088,8341,143471,5710,6478,3018,7316,7979,23198,10868,9958,7157,57599,8312,9491,10197,8348,5692,9960,122706,8737,64135,8334,5695,4609,64750,890,91833,991,80351,11047,8900,128312,7353,8678,5696,10869,5704,8295,8349,5687,5685,10254,3091,8969,55031,7375,63967,5686,8344,4089,9099,5690,1080,7189,23358,10474,5728,10454,6885,5707,2625,4087,6233,9097,23586,329,25862,8078,409,5718,8970,4086,3416,8332,5706,7874,377630,5694,10600,219333,5711,8340,55611,8975,100287144,408,84132,5713,8345,8347,8724,1643,5700,7311,5699,9100,4194,3017,9804,9736,27005,8346,5684,5423,7046,51651,5691,1540,57646,3012,5714,5720,81847,154,4092,221613,8658,10213,27430,4193,5698,90865,8335,5719,84101,7314,9146,993,84196,23032,57695,84749,29761,5702,9817,7419,723790,5693,63891,55288,8313	H2AC7,MUL1,BIRC3,RCE1,VDAC2,USP8,FKBP8,TOMM70,RUVBL1,ATXN7,TAF10,PSMC2,NFKBIA,H2AC25,PSMD9,H2BC7,PSMA1,H2BC8,PSMD11,VDAC1,SUDS3,USP22,SKP2,PSMD6,H2BC18,PSMD2,SMAD3,H2BC15,PSMA8,PSMD4,SIAH2,H2BC3,UBC,SEM1,PSME4,USP20,USP15,TP53,WDR48,AXIN1,PSMF1,PSME3,H2BC17,PSMB4,USP3,PSMB11,RIPK1,IFIH1,H2AC6,PSMB7,MYC,SMURF2,CCNA2,WDR20,CDC20,TNKS2,ADRM1,CCNA1,H2BC26,UFD1,BECN1,PSMB8,USP19,PSMC4,TRRAP,H2BC21,PSMA6,PSMA4,STAM2,HIF1A,H2AC11,USP47,USP4,CLSPN,PSMA5,H2BC6,SMAD4,USP2,PSMB2,CFTR,TRAF6,USP24,TADA3,PTEN,TAB1,MAP3K7,PSMD1,GATA3,SMAD2,RPS27A,USP14,RIGI,BIRC2,USP49,USP5,ARRB2,PSMD12,H2BC11,SMAD1,IDE,H2AC16,PSMC6,USP7,USP17L2,PSMB6,USP16,USP12,PSMD5,H2BC13,OTUB1,USP13,USP17L10,ARRB1,USP42,PSMD7,H2BC9,H2BC4,SNX3,DDB2,PSMC1,UBA52,PSMB10,USP10,MDM4,H2BC5,TOMM20,USP34,USP21,H2BC10,PSMA3,POLB,TGFBR1,PTRH2,PSMB3,CYLD,USP28,H2AC8,PSMD8,PSME1,RNF146,ADRB2,SMAD7,H2AC1,TNKS,PSMD14,MAT2B,MDM2,PSMB9,IL33,H2AC4,PSMD13,USP44,UBB,HGS,CDC25A,USP48,USP33,USP37,USP30,USP25,PSMC3,KEAP1,VDAC3,H2AC19,PSMB5,RNF123,RHOT1,AXIN2
R-HSA-388396	GPCR downstream signaling	0.999999997633585	-2.36641451346924e-09	974	796	0.0881115784812929	9034	10285	9475,341416,2798,390191,6370,390058,7074,256148,3354,23538,50834,408,403278,2771,718,26188,9630,391114,5142,254783,3627,6865,4543,196883,390437,390195,259287,7225,128360,338662,2848,7222,10846,390321,129521,10874,128371,283160,403284,23263,401667,60675,2784,219968,143503,154,135948,50865,390323,10692,5732,83551,114,338755,403244,2776,441911,390199,3579,6863,406974,79544,284383,4986,441933,5744,285601,5581,2917,403282,9826,727,5733,390326,2357,79290,50838,127385,5364,286362,117579,10316,126370,6364,54429,10681,391112,729759,4160,5330,148,5143,6751,79310,4889,254786,26184,389337,26648,10850,3640,351,1394,2492,3062,150,4993,132112,5367,284433,5028,2831,441669,885,134864,51738,392309,183,403239,25791,2150,1268,2829,219959,6343,6360,729966,134,130075,26333,59340,219874,343169,219956,5031,221955,1133,1269,6655,7432,391189,26529,152,53829,390154,5029,26575,2914,388,4922,5724,998,8387,2780,1132,5995,55701,2852,112,391,160851,7984,8490,26539,347169,126541,8622,7433,1907,4159,1241,442191,84539,4995,151306,4923,9846,57113,56477,441670,3709,2787,4158,390445,81696,3708,3357,553,3568,5170,2550,2921,4992,1606,187,3350,6374,10911,57105,390063,150681,5136,26534,5998,2691,1437,6387,56923,6366,8525,1901,219473,301,162998,51083,138804,283093,2781,442186,23236,3562,403277,56670,81285,50837,6003,2774,26735,283189,797,155,9181,3375,5746,81697,2870,23596,3351,79295,5999,2920,81399,26084,390075,391196,346562,594857,219479,79334,2864,6002,2696,2151,165140,2837,728,8386,119695,9934,121364,7905,134083,2767,56656,2786,26496,1906,6754,115,392392,65055,138881,285659,3356,147,390054,390079,5741,1607,391211,26538,10563,10203,403274,138802,5153,26212,128674,441608,8698,120776,5879,109,2520,54331,8503,1910,11245,340980,146850,120796,10287,26664,3362,1813,1232,5580,2793,2911,128366,26692,10161,2147,3718,219982,338442,5726,8811,26707,4295,2867,53637,9287,6750,81050,387,3973,5331,259292,158131,4161,2843,127623,7252,111,1235,5295,92840,796,85397,135,390181,151,26245,7410,4987,390190,3972,390093,6019,170589,7253,1815,259294,2770,623,2641,6846,2916,122740,50839,6352,26693,120793,10000,5293,1812,1233,59345,3363,9628,6915,3269,119679,8392,6869,353299,2792,119765,81341,23620,146,390038,5739,138805,344892,3559,10276,5880,138803,6752,4887,5443,10888,2862,2773,121512,341568,2359,341418,2918,221472,6866,347148,504189,119692,26493,79473,208,8874,2865,9038,3360,2919,5582,1230,2358,392391,389,138882,26090,5290,3558,6755,1237,100271715,94235,551,391192,1081,64805,3577,5731,611,4985,219965,10672,886,5583,2797,10125,57449,10267,222545,8390,282775,115557,2790,346517,26659,135941,5729,256933,9340,8111,387129,390077,26492,338398,219453,219870,10451,23365,3716,3827,50835,7201,5141,6753,2847,26737,283092,196335,9639,122748,79317,403273,343406,144124,338675,140,219858,401994,10886,10022,390271,50940,5539,53831,390260,283111,8388,2740,5179,255725,8997,341799,8527,4991,2788,81470,2922,1128,409,26533,390275,10636,719,1908,26696,8601,283162,221391,1129,23370,8786,392376,3567,799,219986,259296,5150,26686,1909,51764,4157,185,81442,8484,219958,1131,4829,57121,1814,3560,135924,259295,5996,26595,5138,5368,219983,11214,5578,6368,219981,887,5032,5294,8590,23566,81127,5020,1234,9162,124538,6000,6288,4852,26339,138799,7409,11255,22899,29933,643,624,50650,2832,5139,7932,6464,3061,347168,57007,121130,5196,5697,107,5579,401992,125963,2783,81392,445328,7852,64106,5021,2838,84904,121129,431704,81061,122876,57580,10268,286365,11251,1903,83597,153,2693,259286,6870,27115,8526,2768,8383,6453,27199,259290,117,1609,9290,346528,26476,5745,390439,259289,51308,3060,4544,1608,283159,441932,254973,8787,5173,2769,119774,221035,207,6001,128272,113091,64407,120787,27237,84033,26246,552,7204,5144,8477,5997,390261,10887,219484,2695,3352,401665,10235,390265,119772,143502,390327,26219,6363,26740,390429,9568,55160,390168,26166,747,113,136,319100,390431,50649,2782,122742,5734,157,3355,390084,2826,1902,51289,122042,390433,80346,29,5151,1439,2692,257313,390197,339403,259285,10266,2778,58191,4886,133,5737,116,57406,128368,64108,390442,50831,2791,4988,2913,26341,9828,1894,50833,390067,219960,119682,26689,6375,2854,11250,2885,219957,6372,2587,2642,10803,2841,6344,390155,6010,729230,219952,10663,389090,5140,2779,219873,7200,3576,26230,4994,1325,1236,219875,5296,5540,219436,6373,89846,2796,94233,846,119678,79541,59350,26248,9138,341152,5332,2869,2915,1392,219954,11343,9294,504191,5588,1816,84634,6654,442194,3274,390064,2488,7434,393046,9288,2149,390036,283365,1395,441639,50832,2912,3717,392390,121275,26658,108,5291,156,3361,3710,5924,23533,391109,125958,84109,3814,55970	ROCK2,OR6C2,GNRHR,OR5B12,CCL25,OR51B6,TIAM1,OR4S1,HTR1E,OR52A1,TAS2R1,ARRB1,OR5K4,GNAI2,C3,OR1C1,GNA14,OR6K3,PDE4B,OR6C74,CXCL10,TACR2,MTNR1A,ADCY4,OR4N5,OR5AN1,TAS2R41,TRPC6,OR10T2,OR8D4,GPR25,TRPC3,PDE10A,OR6C1,NMS,NMU,OR6K6,OR8D2,OR6C68,MCF2L,OR51A2,PROK2,GNB3,OR5B21,OR51E1,ADRB2,OR2F2,HEBP1,OR6C75,RRH,PTGER2,TAAR8,ADCY8,OR2AG2,OR2T35,GNAQ,OR10J3,OR4D9,CXCR2,TAC1,MIR197,OR4K1,OR2Z1,OPRK1,OR13G1,PTHLH,GPR150,PRKCE,GRM7,OR6C65,ARHGEF11,C5,PTGER3,OR6C76,FPR1,OR13A1,TAS2R13,OR10J5,PLXNB1,OR13C9,RLN3,NMUR1,OR1I1,CCL20,TAS2R5,GNB5,OR6Y1,OR4F29,MC4R,PLCB2,ADRA1A,PDE4C,SSTR1,OR5H2,NPY5R,OR6C3,OR1F2P,ARHGEF37,OR7E24,CCL27,INSL3,APP,CRHR1,FSHR,HCRTR2,ADRA2A,OR2C1,RTP1,PMCH,OR10H5,P2RY1,NPBWR1,OR4Q3,CCK,TAAR1,GHRL,OR13J1,AGT,OR2T27,NGEF,F2RL1,CNR1,XCR1,OR1S1,SCT,CCL16,CIST1,ADORA1,OR9A4,OR7A17,HRH4,OR6T1,OR6F1,OR9Q1,P2RY6,DAGLB,CHRM5,CNR2,SOS2,VIP,OR11L1,OR12D2,ADRA2C,P2RY13,OR5T3,P2RY2,RGS17,GRM4,RHOB,NTS,PTAFR,CDC42,OR1E1,GNAT2,CHRM4,RGR,ARHGEF40,GPER1,ADCY6,RHOG,DGKH,ARHGEF5,RGS5,OR10H1,OR1B1,OR10H4,PDE8B,VIPR1,EDN2,MC3R,LTB4R,OR14J1,MCHR2,OR3A2,GPBAR1,NTSR1,GAB2,TRPC7,CCL28,OR4M1,ITPR2,GNG5,MC2R,OR5AU1,OR5V1,ITPR1,HTR2B,AVPR1B,IL5RA,PDPK1,GABBR1,CXCL3,OR1F1,DGKA,APLNR,HTR1A,CXCL5,UTS2,CYSLTR2,OR51I1,OR6B3,PDE1A,OR10G2,RGS3,GHRH,CSF2,CXCL12,NMUR2,CCL21,DGKZ,S1PR1,OR8K3,ANXA1,OR7D2,GAL,OR13C4,OR4C12,GNAZ,OR2J3,PLCB1,IL3,OR5K3,SUCNR1,OR51E2,TAS2R7,RGS13,GNAL,OR1L3,OR9G4,CALCB,ADRB3,ARHGEF2,IAPP,PTH2R,OR2B2,GRK6,OPN3,HTR1B,OR5H6,RGS4,CXCL2,OR4F16,ARHGEF26,OR52N5,OR2M7,GNAT3,NPS,OR8U3,OR11H2,FFAR1,RGS12,GIPR,F2RL2,OXER1,UTS2R,C5AR1,OR1D5,OR52R1,P2RY14,OR10A7,REEP5,OR2Y1,GNA11,OR2S2,GNG4,OR10A3,EDN1,SSTR4,ADCY9,OR1K1,REEP1,OR1L8,OR2V2,HTR2A,ADRA1B,OR52A5,OR52E8,PTH,DGKB,OR2G6,OR10H2,CXCL13,CALCRL,OR5H15,OR13C8,PDE1B,OR2B6,PROKR2,OR5B3,S1PR4,OR2D2,RAC1,ADCY3,GAST,GNG2,PIK3R3,EDNRB,GPR176,OR52B6,PIK3R6,OR56A1,RGS19,OR7C1,HTR6,DRD2,CCR3,PRKCD,GNGT2,GRM1,OR6P1,OR2W1,LPAR6,F2,JAK3,OR5A1,HCAR2,TAS2R38,GALR2,OR2J2,MLN,FFAR2,S1PR5,TAAR2,SST,OR5AC2,RHOA,LHCGR,PLCB3,TAS2R46,OR1Q1,MC5R,GPR20,OR2B11,TSHB,ADCY5,CCR6,PIK3R1,REEP6,CALCA,RGS8,ADORA2A,OR5AK2,ADRA2B,OR2M4,VAV2,OPRL1,OR5B2,LHB,OR10A6,RLN2,GPHA2,TSHR,DRD4,TAS2R19,GNAI1,BDKRB1,GCG,XCL2,GRM6,OR4K14,TAS2R10,CCL5,OR2V1,OR56A4,AKT3,PIK3CD,DRD1,CCR4,GNB4,HTR7,RGS6,TBXA2R,HRH1,OR52J3,OR3A3,TACR1,RGSL1,GNGT1,OR4B1,OR10W1,NTSR2,ADRA1D,OR51D1,PTGIR,OR13F1,RTP2,IL2RA,NET1,RAC2,OR13C3,SSTR2,NPY2R,POMC,GPR83,MLNR,GNAI3,FGD4,OR8S1,FPR3,OR6C4,GRM8,FGD2,TAC3,QRFP,OR8U8,OR51S1,OR8B8,OR52N1,AKT2,ARHGEF7,FFAR3,TAAR5,HTR4,CXCL1,PRKCG,CCR1,FPR2,OR5C1,RHOC,OR1N2,ABHD12,PIK3CA,IL2,SSTR5,CCR8,ARHGEF33,GNG8,AVP,OR2L3,CGA,P2RY12,CXCR1,PTGER1,OPN1SW,OPRD1,OR5B17,GNA13,CCKAR,PRKCH,GNRH2,RASGRP1,PLEKHG5,RAMP1,GPRC6A,OR1G1,OR5J2,ARHGEF25,GNG10,OR6V1,OR7A5,OR2A14,PTGDR,NPB,GLP2R,GPR68,NPSR1,OR52N2,OR8G2P,TAS2R60,OR8K5,OR10G9,VAV3,ARHGEF12,JAK1,KNG1,TAS2R9,TRHR,PDE4A,SSTR3,MCHR1,OR1L1,OR4C13,OR56B4,ARHGEF10,OR11H6,OR4K5,OR5H14,OR10R2,OR10A5,OR5AP2,ADORA3,OR8B12,OR14I1,NPFFR2,INSL5,OR8B3,PDE11A,PPY,GPR84,OR6X1,OR51V1,OR1E2,GLP1R,PENK,OR52B2,KALRN,OR6S1,DGKD,OR1D2,GNG7,OR2G2,GRP,CHRM1,ARRB2,OR10G3,OR8A1,RGS14,C3AR1,EDN3,OR2T1,RGS20,OR8B4,OPN5,CHRM2,ARHGEF18,RGS11,OR13C2,IL5,CALCR,OR4D11,TAS2R50,PDE7A,OR4E2,EDNRA,GNG13,MC1R,AGTR1,OR6N2,GALR3,OR1S2,CHRM3,NMBR,LPAR5,DRD3,IL2RB,OR9A2,TAS2R20,RGS1,OR8B2,PDE2A,PNOC,OR4D6,AKAP13,PRKCA,CCL23,OR5A2,CCKBR,P2RY11,PIK3CG,OR6A2,LPAR3,OR4K15,OXT,CCR5,DGKI,OR4D2,RGS7,SAA1,NPY,OR5K1,OR13C5,VAV1,HRH3,ARHGEF15,GPR132,CXCR5,BDKRB2,ARHGEF3,NPBWR2,PDE3A,OR2H2,SHC1,HCRTR1,OR1J1,ACKR3,OR10P1,PF4,PYY,ADCY1,PRKCB,OR2T2,OR1M1,GNB2,OR2AE1,ARHGEF35,CXCR4,NPFFR1,OXTR,GPR15,ARHGEF39,OR2AP1,RGS21,OR11H1,GPHB5,PREX1,RAMP3,OR13D1,PTGDR2,S1PR3,RTP3,ADRB1,GHSR,TAS2R40,TACR3,PDE7B,DGKE,GNA12,OR1A1,ITSN1,OXGR1,TAS2R31,ADCYAP1R1,DGKQ,GPR55,OR2A1,OR10J1,PTH1R,OR11G2,TAS2R43,REEP2,HCRT,MTNR1B,DGKG,OR8D1,OR2W5P,OR1L4,RGS9,PDYN,GNA15,OR52K2,REEP3,AKT1,RGS10,ARHGEF19,PTH2,RGS18,OR52W1,ARHGEF16,OBSCN,OR2L2,AVPR1A,TRIO,PDE4D,GPR65,RGS2,OR6M1,PROKR1,OR5M8,GIP,HTR1D,OR51T1,RASGRP2,OR10G7,OR52M1,OR52I2,OR6C70,OR1J4,CCL19,OR1J2,OR4N2,GABBR2,ARHGEF10L,OR5M1,RGS22,DAGLA,ADCY7,ADORA2B,TAAR6,OR4K2,ARHGEF4,GNB1,OR4L1,PTGER4,GRK3,HTR1F,OR56A5,CCR10,LPAR1,RXFP3,RXFP2,OR4K13,REEP4,ABR,PDE8A,CSF2RB,GHRHR,UTS2B,OR4D10,RXFP4,TAS2R39,RAMP2,GNAS,CXCL16,NPY1R,ADM,PTGFR,ADCYAP1,ABHD6,OR10Z1,RTP4,OR11H4,TAS2R3,GNG11,OPRM1,GRM3,OR5H1,ARHGEF17,ECT2,TAS2R16,OR52H1,OR10Q1,OR51L1,OR4D1,XCL1,GPR32,GPR45,GRB2,OR9Q2,CXCL6,GALR1,GCGR,CCR9,GPR18,SCTR,OR5T1,RHO,CCR2,OR6Q1,CXCR6,OR6B2,PDE3B,GNAT1,OR10S1,TRH,CXCL8,TIAM2,OR3A1,CORT,CCR7,OR4D5,PIK3R2,NPY4R,OR5D14,CXCL11,FGD3,GNRH1,OPN4,CASR,OR52E2,OR2A4,RXFP1,OR2K2,ARHGEF1,OR2AT4,PLCB4,GRK5,GRM5,CRH,OR9I1,MGLL,S1PR2,OR9G9,PRKCQ,DRD5,KISS1R,SOS1,OR10C1,HRH2,OR51I2,FSHB,VIPR2,OR2A5,TAAR3P,F2R,OR52K1,OR6C6,CRHR2,OR9K2,TAS2R4,GRM2,JAK2,OR1L6,OR10AD1,OR7C2,ADCY2,PIK3CB,GRK2,HTR5A,ITPR3,RASGRF2,PIK3R5,OR10K1,OR7D4,QRFPR,KISS1,GNG12
R-HSA-381753	Olfactory Signaling Pathway	0.999999999951164	-4.88364942274828e-11	391	262	0.0290015497011291	9034	10285	138802,26212,26737,122742,729759,391112,390084,26538,403274,390054,127385,286362,391211,390431,390079,126370,2782,219870,79290,343406,26184,390197,79310,254786,120776,403273,196335,283092,390433,441608,79317,122748,80346,284383,8386,119695,219484,441933,8390,390261,79544,219965,441911,390199,26246,219479,338755,79334,403244,26492,392392,138881,65055,390326,285659,390168,219453,26496,26219,26740,390429,390077,346517,390265,403282,26659,119772,143502,135941,56656,390327,401665,282775,121364,134083,7905,283160,128371,392391,119774,138882,403284,79295,283159,51308,390321,441932,81697,254973,26735,390439,283189,79473,26476,346528,504189,128360,338662,26493,2774,119692,135948,391192,390323,120787,391196,390075,81399,219968,401667,143503,221035,81061,403278,286365,138803,390191,390058,344892,256148,121129,26534,23538,125963,341416,81392,138805,341418,81285,403277,390437,442186,390195,8383,219473,254783,341568,283093,138804,162998,83597,391114,26188,392390,4992,119679,26658,8392,121275,283365,120793,26339,138799,441639,390445,81696,26693,390036,124538,390064,393046,150681,390063,401992,347168,125958,121130,390038,119765,2792,81341,391109,7932,390093,341152,79541,26248,8387,26245,219983,390190,119678,219436,26595,442194,441670,504191,8590,81127,122740,219954,442191,4995,26539,219981,347169,126541,81050,390155,219952,219956,343169,26707,219874,26686,392376,219986,219957,130075,219982,26333,92840,219875,135924,390181,4994,390154,219873,391189,127623,219958,26529,389090,81442,158131,284433,26341,255725,341799,128368,64108,120796,4993,390260,8388,26664,390442,132112,283111,401994,390271,340980,338675,144124,26648,219858,219959,26696,283162,26692,119682,219960,26689,26533,390275,390067,128366,392309,403239,4991,441669,81470	OR13C8,OR2B6,OR1L1,OR4L1,OR4F29,OR6Y1,OR56A5,OR10H2,OR5H15,OR52A5,OR10J5,OR13C9,OR2G6,OR4K2,OR52E8,OR1I1,GNB1,OR10G9,OR13A1,OR10R2,OR1F2P,OR4D10,OR5H2,OR6C3,OR2D2,OR5H14,OR56B4,OR4C13,OR4K13,OR5B3,OR4K5,OR11H6,REEP4,OR2Z1,OR1D5,OR52R1,OR5M8,OR13G1,OR1G1,OR6M1,OR4K1,OR5B17,OR10J3,OR4D9,OR2L2,OR8U3,OR2AG2,OR11H2,OR2T35,OR8G2P,OR1K1,OR1L8,REEP1,OR6C76,OR2V2,OR5M1,OR8K5,OR10A3,OR1J4,OR1J2,OR4N2,OR52N2,OR6V1,OR10G7,OR6C65,OR7A5,OR52M1,OR52I2,OR2A14,OR2S2,OR6C70,OR51T1,OR5J2,OR10A7,OR2Y1,REEP5,OR8D2,OR6K6,OR5C1,OR52K2,OR1N2,OR6C68,OR5H6,OR8D1,REEP2,OR6C1,OR2W5P,OR2B2,OR1L4,OR1L3,OR11G2,OR9G4,OR52N1,OR10J1,OR2A1,OR8U8,OR10T2,OR8D4,OR8B8,GNAL,OR51S1,OR2F2,OR2L3,OR6C75,OR52W1,OR2M7,OR52N5,OR4F16,OR5B21,OR51A2,OR51E1,REEP3,OR11H1,OR5K4,OR13D1,OR13C3,OR5B12,OR51B6,RTP2,OR4S1,OR2AP1,OR10G2,OR52A1,OR1M1,OR6C2,OR2AE1,OR13F1,OR6C4,OR51E2,OR5K3,OR4N5,OR2J3,OR5AN1,OR1A1,OR8K3,OR6C74,OR8S1,OR4C12,OR13C4,OR7D2,RTP3,OR6K3,OR1C1,OR1L6,OR1F1,OR52J3,OR7C2,OR3A3,OR10AD1,OR6C6,OR56A4,OR5K1,OR13C5,OR9K2,OR5AU1,OR5V1,OR2V1,OR52K1,OR4D2,OR51I2,OR2A5,OR6B3,OR51I1,OR2T2,OR1J1,OR7D4,OR10P1,OR51D1,OR4B1,GNGT1,OR10W1,OR10K1,OR2H2,OR10A6,OR2AT4,OR2A4,OR2K2,OR1E1,OR2M4,OR4D6,OR5B2,OR52E2,OR5D14,OR8B2,OR10C1,OR4M1,OR9G9,OR6A2,OR4K15,OR4K14,OR9I1,OR14J1,OR3A2,OR10H1,OR5A2,OR1B1,OR10H4,OR5AC2,OR5T1,OR6Q1,OR9Q1,OR6F1,OR2J2,OR6T1,OR4E2,OR13C2,OR4D11,OR9Q2,OR9A4,OR5A1,OR7A17,REEP6,OR4D5,OR9A2,OR5AK2,OR3A1,OR5T3,OR10S1,OR11L1,OR2B11,OR1S2,OR12D2,OR6B2,OR6N2,OR1Q1,OR10H5,OR5H1,OR52B2,OR6S1,OR10Z1,RTP4,OR56A1,OR2C1,OR6X1,OR1E2,OR7C1,OR11H4,RTP1,OR51V1,OR14I1,OR8B3,OR52B6,OR5AP2,OR10A5,OR7E24,OR8B12,OR1S1,OR2T1,OR8B4,OR2W1,OR51L1,OR10Q1,OR4D1,OR10G3,OR8A1,OR52H1,OR6P1,OR13J1,OR2T27,OR1D2,OR4Q3,OR2G2
R-HSA-141333	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	0.999999999992697	-7.30349114519413e-12	2	0	0	9034	10285
R-HSA-3359454	Defective TCN2 causes hereditary megaloblastic anemia	1.00000000000366	3.65973917837437e-12	1	0	0	9034	10285
R-HSA-1300645	Acrosome Reaction	1.00000000000366	3.65973917837437e-12	1	0	0	9034	10285
R-HSA-5340573	WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	1.00000000000366	3.65973917837437e-12	1	0	0	9034	10285
R-HSA-168330	Viral RNP Complexes in the Host Cell Nucleus	1.00000000000366	3.65973917837437e-12	1	0	0	9034	10285
R-HSA-3359474	Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	1.00000000000366	3.65973917837437e-12	1	0	0	9034	10285