TermID	Term	Enrichment	logP	Genes in Term	Target Genes in Term	Fraction of Targets in Term	Total Target Genes	Total Genes	Entrez Gene IDs	Gene Symbols
vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2	0.037676341112887	-3.27872293821164	63	62	0.0301850048685492	2054	2226	7414,5594,3265,1003,3091,2887,3320,2185,5290,2034,6461,9175,5595,5566,5829,4846,405,808,5335,801,4734,998,5578,7424,2885,2549,387,9047,7525,2321,6714,7422,857,5170,6654,8829,3690,805,8826,3685,2534,5295,10818,6464,25759,2242,3791,1901,5777,8828,5058,207,7423,5879,7428,2324,5606,4690,1499,5781,3315,5600	VCL,MAPK1,HRAS,CDH5,HIF1A,GRB10,HSP90AA1,PTK2B,PIK3CA,EPAS1,SHB,MAP3K13,MAPK3,PRKACA,PXN,NOS3,ARNT,CALM3,PLCG1,CALM1,NEDD4,CDC42,PRKCA,VEGFC,GRB2,GAB1,RHOA,SH2D2A,YES1,FLT1,SRC,VEGFA,CAV1,PDPK1,SOS1,NRP1,ITGB3,CALM2,IQGAP1,ITGAV,FYN,PIK3R1,FRS2,SHC1,SHC2,FES,KDR,S1PR1,PTPN6,NRP2,PAK1,AKT1,VEGFB,RAC1,VHL,FLT4,MAP2K3,NCK1,CTNNB1,PTPN11,HSPB1,MAPK11
reg_gr_pathway	Glucocorticoid receptor regulatory network	0.0399944616136935	-3.21901429411229	82	80	0.0389483933787731	2054	2226	7251,1081,207,2266,2289,5617,3567,3569,581,5567,5601,6772,2810,6446,5600,5443,2353,3852,6601,1020,3565,2932,1447,3596,1958,2033,30009,1026,3872,6777,3066,3164,2625,5087,9970,7157,6602,3383,1432,5970,5602,632,6776,6599,8648,3861,3576,6597,1385,4312,5536,2908,4772,5599,174,8851,3065,3725,5594,6401,2288,1437,5451,5568,51111,10499,4193,5449,3659,3320,6688,5566,7533,5595,3458,4790,7433,6613,3558,1387	TSG101,CGA,AKT1,FGG,FKBP5,PRL,IL5,IL6,BAX,PRKACB,MAPK9,STAT1,SFN,SGK1,MAPK11,POMC,FOS,KRT5,SMARCC2,CDK5,IL4,GSK3B,CSN2,IL13,EGR1,EP300,TBX21,CDKN1A,KRT17,STAT5B,HDAC2,NR4A1,GATA3,PBX1,NR1I3,TP53,SMARCD1,ICAM1,MAPK14,RELA,MAPK10,BGLAP,STAT5A,SMARCC1,NCOA1,KRT14,CXCL8,SMARCA4,CREB1,MMP1,PPP5C,NR3C1,NFATC1,MAPK8,AFP,CDK5R1,HDAC1,JUN,MAPK1,SELE,FKBP4,CSF2,POU2F1,PRKACG,KMT5B,NCOA2,MDM2,POU1F1,IRF1,HSP90AA1,SPI1,PRKACA,YWHAH,MAPK3,IFNG,NFKB1,VIPR1,SUMO2,IL2,CREBBP
mtor_4pathway	mTOR signaling pathway	0.0462958904703551	-3.07270208056887	60	59	0.0287244401168452	2054	2226	7532,6249,79109,6198,10971,6720,9776,7534,2475,64223,7249,207,5338,5879,54205,29904,2810,5371,1978,84271,7528,1938,64798,898,6446,10891,3551,5337,7248,5594,253260,673,27250,54700,1977,9821,5595,7533,1017,7529,5829,6195,7531,3667,8945,5605,5894,664,5578,57521,54541,23291,6009,387,84335,5604,5170,1975,55615	YWHAG,CLIP1,MAPKAP1,RPS6KB1,YWHAQ,SREBF1,ATG13,YWHAZ,MTOR,MLST8,TSC2,AKT1,PLD2,RAC1,CYCS,EEF2K,SFN,PML,EIF4EBP1,POLDIP3,YY1,EEF2,DEPTOR,CCNE1,SGK1,PPARGC1A,IKBKB,PLD1,TSC1,MAPK1,RICTOR,BRAF,PDCD4,RRN3,EIF4E,RB1CC1,MAPK3,YWHAH,CDK2,YWHAB,PXN,RPS6KA1,YWHAE,IRS1,BTRC,MAP2K2,RAF1,BNIP3,PRKCA,RPTOR,DDIT4,FBXW11,RHEB,RHOA,AKT1S1,MAP2K1,PDPK1,EIF4B,PRR5
tcptp_pathway	Signaling events mediated by TCPTP	0.0539885841729344	-2.9189826589718	36	36	0.0175267770204479	2054	2226	3688,3630,3643,5291,3838,3998,5290,5867,5295,1950,3791,5610,6777,1956,3672,1387,8554,3837,3718,6774,1435,6776,5770,545,2885,2549,6778,3082,6772,4233,7422,6714,6654,5159,3716,1436	ITGB1,INS,INSR,PIK3CB,KPNA2,LMAN1,PIK3CA,RAB4A,PIK3R1,EGF,KDR,EIF2AK2,STAT5B,EGFR,ITGA1,CREBBP,PIAS1,KPNB1,JAK3,STAT3,CSF1,STAT5A,PTPN1,ATR,GRB2,GAB1,STAT6,HGF,STAT1,MET,VEGFA,SRC,SOS1,PDGFRB,JAK1,CSF1R
ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction	0.0689873552101776	-2.67383204900216	33	33	0.0160662122687439	2054	2226	7410,8907,55740,3728,5290,2889,10006,382,1500,3682,8826,999,1739,1398,5295,4830,1495,7082,7074,998,10787,5879,3695,207,2017,10163,1499,27252,26999,387,595,23396,6714	VAV2,AP1M1,ENAH,JUP,PIK3CA,RAPGEF1,ABI1,ARF6,CTNND1,ITGAE,IQGAP1,CDH1,DLG1,CRK,PIK3R1,NME1,CTNNA1,TJP1,TIAM1,CDC42,NCKAP1,RAC1,ITGB7,AKT1,CTTN,WASF2,CTNNB1,KLHL20,CYFIP2,RHOA,CCND1,PIP5K1C,SRC
endothelinpathway	Endothelins	0.0742443661488788	-2.60039338096089	53	52	0.0253164556962025	2054	2226	4312,5582,387,6714,5604,5599,196883,1910,5605,1909,1432,5894,1278,9564,1907,2768,998,5578,112,114,5595,107,3717,5594,3725,6550,3265,111,5321,2185,7225,5330,5588,2353,23236,5331,5583,1281,207,5580,109,6548,115,5879,5581,1398,113,1906,57105,5058,1908,108	MMP1,PRKCG,RHOA,SRC,MAP2K1,MAPK8,ADCY4,EDNRB,MAP2K2,EDNRA,MAPK14,RAF1,COL1A2,BCAR1,EDN2,GNA12,CDC42,PRKCA,ADCY6,ADCY8,MAPK3,ADCY1,JAK2,MAPK1,JUN,SLC9A3,HRAS,ADCY5,PLA2G4A,PTK2B,TRPC6,PLCB2,PRKCQ,FOS,PLCB1,PLCB3,PRKCH,COL3A1,AKT1,PRKCD,ADCY3,SLC9A1,ADCY9,RAC1,PRKCE,CRK,ADCY7,EDN1,CYSLTR2,PAK1,EDN3,ADCY2
erbb4_pathway	ErbB4 signaling events	0.0748557157919621	-2.59219280774596	32	32	0.0155793573515093	2054	2226	10413,26018,1742,2064,6868,5617,2904,9611,2885,23118,4734,1839,6776,6777,5595,51741,145957,83737,5295,6464,11059,2069,5291,5618,5594,3717,2534,5290,4193,10718,685,863	YAP1,LRIG1,DLG4,ERBB2,ADAM17,PRL,GRIN2B,NCOR1,GRB2,TAB2,NEDD4,HBEGF,STAT5A,STAT5B,MAPK3,WWOX,NRG4,ITCH,PIK3R1,SHC1,WWP1,EREG,PIK3CB,PRLR,MAPK1,JAK2,FYN,PIK3CA,MDM2,NRG3,BTC,CBFA2T3
avb3_opn_pathway	Osteopontin-mediated events	0.0748557157919621	-2.59219280774596	32	32	0.0155793573515093	2054	2226	5595,5295,4790,9475,5058,5328,2934,3611,10451,3725,5594,1147,3685,5290,2185,4792,4318,387,3690,6696,9020,2353,5599,9564,6850,8394,960,4313,5970,5879,998,4214	MAPK3,PIK3R1,NFKB1,ROCK2,PAK1,PLAU,GSN,ILK,VAV3,JUN,MAPK1,CHUK,ITGAV,PIK3CA,PTK2B,NFKBIA,MMP9,RHOA,ITGB3,SPP1,MAP3K14,FOS,MAPK8,BCAR1,SYK,PIP5K1A,CD44,MMP2,RELA,RAC1,CDC42,MAP3K1
a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling	0.081220116738904	-2.51059231940781	31	31	0.0150925024342746	2054	2226	7533,1308,6198,10971,1950,5295,6464,3552,7531,7534,7529,1956,7532,999,3265,3688,5290,840,3691,4233,4485,5376,2065,2810,928,2064,3655,4486,207,2885,5578	YWHAH,COL17A1,RPS6KB1,YWHAQ,EGF,PIK3R1,SHC1,IL1A,YWHAE,YWHAZ,YWHAB,EGFR,YWHAG,CDH1,HRAS,ITGB1,PIK3CA,CASP7,ITGB4,MET,MST1,PMP22,ERBB3,SFN,CD9,ERBB2,ITGA6,MST1R,AKT1,GRB2,PRKCA
aurora_a_pathway	Aurora A signaling	0.081220116738904	-2.51059231940781	31	31	0.0150925024342746	2054	2226	2932,9212,54998,6867,10460,64506,4193,23424,4792,28964,81565,5566,22974,1058,5901,5921,6790,5528,5058,7157,84962,332,207,4946,9793,9787,8874,994,672,1647,51343	GSK3B,AURKB,AURKAIP1,TACC1,TACC3,CPEB1,MDM2,TDRD7,NFKBIA,GIT1,NDEL1,PRKACA,TPX2,CENPA,RAN,RASA1,AURKA,PPP2R5D,PAK1,TP53,AJUBA,BIRC5,AKT1,OAZ1,CKAP5,DLGAP5,ARHGEF7,CDC25B,BRCA1,GADD45A,FZR1
nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0847685103760358	-2.46783114505325	51	50	0.0243427458617332	2054	2226	836,3164,1827,10971,7534,5292,805,2033,7532,2932,5590,1326,2810,5601,5588,4209,814,3837,5583,5580,4773,23523,5581,9495,11261,5901,2280,7533,5566,5595,1387,7531,1452,7529,23770,3838,7514,5582,4775,4772,1457,5599,8021,1432,596,10231,5578,4214,801,808	CASP3,NR4A1,RCAN1,YWHAQ,YWHAZ,PIM1,CALM2,EP300,YWHAG,GSK3B,PRKCZ,MAP3K8,SFN,MAPK9,PRKCQ,MEF2D,CAMK4,KPNB1,PRKCH,PRKCD,NFATC2,CABIN1,PRKCE,AKAP5,CHP1,RAN,FKBP1A,YWHAH,PRKACA,MAPK3,CREBBP,YWHAE,CSNK1A1,YWHAB,FKBP8,KPNA2,XPO1,PRKCG,NFATC3,NFATC1,CSNK2A1,MAPK8,NUP214,MAPK14,BCL2,RCAN2,PRKCA,MAP3K1,CALM1,CALM3
ptp1bpathway	Signaling events mediated by PTP1B	0.0905382624696672	-2.40198272790657	50	49	0.0238558909444985	2054	2226	3630,1447,50507,2212,3952,2534,6464,1398,5295,1950,6777,10253,1956,27040,7297,5617,207,6774,4067,1445,3932,9021,7295,2268,1436,823,5159,3717,3643,1000,5618,3674,5290,2241,4904,3953,1796,3667,640,9564,1435,6776,5770,2885,387,7525,857,6714,3690	INS,CSN2,NOX4,FCGR2A,LEP,FYN,SHC1,CRK,PIK3R1,EGF,STAT5B,SPRY2,EGFR,LAT,TYK2,PRL,AKT1,STAT3,LYN,CSK,LCK,SOCS3,TXN,FGR,CSF1R,CAPN1,PDGFRB,JAK2,INSR,CDH2,PRLR,ITGA2B,PIK3CA,FER,YBX1,LEPR,DOK1,IRS1,BLK,BCAR1,CSF1,STAT5A,PTPN1,GRB2,RHOA,YES1,CAV1,SRC,ITGB3
insulin_glucose_pathway	Insulin-mediated glucose transport	0.0956071707071908	-2.3475074543403	29	29	0.0141187925998053	2054	2226	6844,7533,10971,7531,2997,7534,7529,434,6517,3643,805,3630,7532,23433,2932,5506,5501,5590,6810,4012,2810,208,207,9882,252983,801,9322,808,5584	VAMP2,YWHAH,YWHAQ,YWHAE,GYS1,YWHAZ,YWHAB,ASIP,SLC2A4,INSR,CALM2,INS,YWHAG,RHOQ,GSK3B,PPP1R3A,PPP1CC,PRKCZ,STX4,LNPEP,SFN,AKT2,AKT1,TBC1D4,STXBP4,CALM1,TRIP10,CALM3,PRKCI
vegfr1_pathway	VEGFR1 specific signals	0.0956071707071908	-2.3475074543403	29	29	0.0141187925998053	2054	2226	3091,867,5594,805,5290,3320,5595,5566,5921,5295,25759,8828,4846,5228,23607,7423,207,5335,808,5578,801,2321,857,7422,2549,8829,5170,4690,5781	HIF1A,CBL,MAPK1,CALM2,PIK3CA,HSP90AA1,MAPK3,PRKACA,RASA1,PIK3R1,SHC2,NRP2,NOS3,PGF,CD2AP,VEGFB,AKT1,PLCG1,CALM3,PRKCA,CALM1,FLT1,CAV1,VEGFA,GAB1,NRP1,PDPK1,NCK1,PTPN11
il12_stat4pathway	IL12 signaling mediated by STAT4	0.103723870293739	-2.26602300418199	28	28	0.0136319376825706	2054	2226	940,3122,1387,3558,915,7040,920,3458,919,3123,30009,3659,3596,916,5551,3725,8809,6775,5599,2353,8807,3559,5601,3606,6774,9063,2119,917	CD28,HLA-DRA,CREBBP,IL2,CD3D,TGFB1,CD4,IFNG,CD247,HLA-DRB1,TBX21,IRF1,IL13,CD3E,PRF1,JUN,IL18R1,STAT4,MAPK8,FOS,IL18RAP,IL2RA,MAPK9,IL18,STAT3,PIAS2,ETV5,CD3G
hif1_tfpathway	HIF-1-alpha transcription factor network	0.109342884161711	-2.21326660794374	65	63	0.0306718597857838	2054	2226	3162,3952,10397,2624,9429,2033,226,7015,6387,1906,7852,10987,3939,7033,54583,2113,5045,2645,6513,3172,2022,3689,207,3099,4170,5236,2353,5315,10370,4088,2056,10499,1356,4869,5054,3091,3725,2235,3098,3398,768,51564,1387,4089,133,6667,7018,123,4907,8553,5211,664,7037,79365,405,3484,112399,5209,2023,8648,7422,5243,1385	HMOX1,LEP,NDRG1,GATA2,ABCG2,EP300,ALDOA,TERT,CXCL12,EDN1,CXCR4,COPS5,LDHA,TFF3,EGLN1,ETS1,FURIN,GCK,SLC2A1,HNF4A,ENG,ITGB2,AKT1,HK2,MCL1,PGM1,FOS,PKM,CITED2,SMAD3,EPO,NCOA2,CP,NPM1,SERPINE1,HIF1A,JUN,FECH,HK1,ID2,CA9,HDAC7,CREBBP,SMAD4,ADM,SP1,TF,PLIN2,NT5E,BHLHE40,PFKL,BNIP3,TFRC,BHLHE41,ARNT,IGFBP1,EGLN3,PFKFB3,ENO1,NCOA1,VEGFA,ABCB1,CREB1
fgf_pathway	FGF signaling pathway	0.11011088410502	-2.2062673835998	47	46	0.0223953261927945	2054	2226	2549,4233,6714,6654,5170,6696,2264,9965,54756,5335,632,6383,2885,5595,8074,6195,5328,4684,5594,815,10298,3725,1000,999,2185,5290,2246,860,3082,6772,4318,2353,5781,5329,2017,207,54434,2260,2263,5295,10818,6464,6777,10253,1500,867	GAB1,MET,SRC,SOS1,PDPK1,SPP1,FGFR4,FGF19,IL17RD,PLCG1,BGLAP,SDC2,GRB2,MAPK3,FGF23,RPS6KA1,PLAU,NCAM1,MAPK1,CAMK2A,PAK4,JUN,CDH2,CDH1,PTK2B,PIK3CA,FGF1,RUNX2,HGF,STAT1,MMP9,FOS,PTPN11,PLAUR,CTTN,AKT1,SSH1,FGFR1,FGFR2,PIK3R1,FRS2,SHC1,STAT5B,SPRY2,CTNND1,CBL
il27pathway	IL27-mediated signaling events	0.122068869985492	-2.10316988544582	26	26	0.0126582278481013	2054	2226	3717,3594,3593,30009,3553,3595,10148,3458,2625,7040,3558,3592,7297,7124,3605,6773,3569,3572,6776,6774,9466,3606,6772,246778,6775,3716	JAK2,IL12RB1,IL12B,TBX21,IL1B,IL12RB2,EBI3,IFNG,GATA3,TGFB1,IL2,IL12A,TYK2,TNF,IL17A,STAT2,IL6,IL6ST,STAT5A,STAT3,IL27RA,IL18,STAT1,IL27,STAT4,JAK1
retinoic_acid_pathway	Retinoic acid receptors-mediated signaling	0.132416748565161	-2.02180114374278	25	25	0.0121713729308666	2054	2226	983,8850,6256,10499,5594,3065,5947,1022,6258,5566,902,5595,5578,7421,1432,207,8204,8841,8202,5914,5599,4331,9612,5582,8648	CDK1,KAT2B,RXRA,NCOA2,MAPK1,HDAC1,RBP1,CDK7,RXRG,PRKACA,CCNH,MAPK3,PRKCA,VDR,MAPK14,AKT1,NRIP1,HDAC3,NCOA3,RARA,MAPK8,MNAT1,NCOR2,PRKCG,NCOA1
arf6_traffickingpathway	Arf6 trafficking events	0.133521751845738	-2.01349087924026	44	43	0.0209347614410906	2054	2226	1363,23162,154,3675,6517,23265,3831,3672,999,3688,5337,8853,966,11336,1910,60412,3655,1495,4830,9744,9043,382,1500,54536,3630,3728,3673,9341,10066,1129,55763,55770,23396,274,5898,6382,3559,1499,1785,5338,10640,1213,7253	CPE,MAPK8IP3,ADRB2,ITGA3,SLC2A4,EXOC7,KLC1,ITGA1,CDH1,ITGB1,PLD1,ASAP2,CD59,EXOC3,EDNRB,EXOC4,ITGA6,CTNNA1,NME1,ACAP1,SPAG9,ARF6,CTNND1,EXOC6,INS,JUP,ITGA2,VAMP3,SCAMP2,CHRM2,EXOC1,EXOC2,PIP5K1C,BIN1,RALA,SDC1,IL2RA,CTNNB1,DNM2,PLD2,EXOC5,CLTC,TSHR
hnf3bpathway	FOXA2 and FOXA3 transcription factor networks	0.133521751845738	-2.01349087924026	44	43	0.0209347614410906	2054	2226	34,3767,1374,211,3157,6898,3651,3033,2294,3172,3169,2645,7351,207,335,37,5105,1052,7276,4763,3630,8788,2908,3170,1385,2147,3171,126129,213,622,3484,5313,6514,6927,7037,6833,6667,229,2538,1051,7080,174,1050	ACADM,KCNJ11,CPT1A,ALAS1,HMGCS1,TAT,PDX1,HADH,FOXF1,HNF4A,FOXA1,GCK,UCP2,AKT1,APOA1,ACADVL,PCK1,CEBPD,TTR,NF1,INS,DLK1,NR3C1,FOXA2,CREB1,F2,FOXA3,CPT1C,ALB,BDH1,IGFBP1,PKLR,SLC2A2,HNF1A,TFRC,ABCC8,SP1,ALDOB,G6PC1,CEBPB,NKX2-1,AFP,CEBPA
insulin_pathway	Insulin Pathway	0.142283623454513	-1.94993286515761	43	42	0.0204479065238559	2054	2226	8440,1796,3667,23265,10603,6198,6464,5921,5295,2309,5290,5590,2887,23433,867,54536,2889,3265,3643,3630,208,6446,11336,5781,5786,5170,6654,4690,60412,857,2151,1978,55763,55770,2885,5584,5770,9322,10580,2888,207,10640	NCK2,DOK1,IRS1,EXOC7,SH2B2,RPS6KB1,SHC1,RASA1,PIK3R1,FOXO3,PIK3CA,PRKCZ,GRB10,RHOQ,CBL,EXOC6,RAPGEF1,HRAS,INSR,INS,AKT2,SGK1,EXOC3,PTPN11,PTPRA,PDPK1,SOS1,NCK1,EXOC4,CAV1,F2RL2,EIF4EBP1,EXOC1,EXOC2,GRB2,PRKCI,PTPN1,TRIP10,SORBS1,GRB14,AKT1,EXOC5
cxcr4_pathway	CXCR4-mediated signaling events	0.14753912556585	-1.9136618803034	76	73	0.0355404089581305	2054	2226	6776,2870,55824,640,1759,3655,9564,6773,5170,3984,6714,7525,2185,9146,5908,5290,3717,3688,5291,253260,3672,5829,5899,29979,3122,919,27183,3675,5747,920,2782,4067,6774,10672,2308,1445,54434,409,9525,207,5788,917,1072,2268,5781,5331,23236,156,3932,4318,5330,6772,3673,10399,5590,2534,3123,916,7852,54331,5777,5058,6387,2475,64223,7409,1398,79109,5295,83737,915,5996,6777	STAT5A,GRK6,PAG1,BLK,DNM1,ITGA6,BCAR1,STAT2,PDPK1,LIMK1,SRC,YES1,PTK2B,HGS,RAP1B,PIK3CA,JAK2,ITGB1,PIK3CB,RICTOR,ITGA1,PXN,RALB,UBQLN1,HLA-DRA,CD247,VPS4A,ITGA3,PTK2,CD4,GNB1,LYN,STAT3,GNA13,FOXO1,CSK,SSH1,ARRB2,VPS4B,AKT1,PTPRC,CD3G,CFL1,FGR,PTPN11,PLCB3,PLCB1,GRK2,LCK,MMP9,PLCB2,STAT1,ITGA2,RACK1,PRKCZ,FYN,HLA-DRB1,CD3E,CXCR4,GNG2,PTPN6,PAK1,CXCL12,MTOR,MLST8,VAV1,CRK,MAPKAP1,PIK3R1,ITCH,CD3D,RGS1,STAT5B
lkb1_pathway	LKB1 signaling events	0.151564471897464	-1.88674418747747	42	41	0.0199610516066212	2054	2226	55437,6604,9024,1509,57787,84335,51719,1385,4133,2810,57521,92335,5664,7249,2011,2475,7157,64223,23387,7531,114790,7534,6794,7529,11140,7430,7533,5566,10971,4089,150094,84446,23235,200186,4609,3320,2099,2932,7532,2118,7248	STRADB,SMARCD3,BRSK2,CTSD,MARK4,AKT1S1,CAB39,CREB1,MAP2,SFN,RPTOR,STRADA,PSEN2,TSC2,MARK2,MTOR,TP53,MLST8,SIK3,YWHAE,STK11IP,YWHAZ,STK11,YWHAB,CDC37,EZR,YWHAH,PRKACA,YWHAQ,SMAD4,SIK1,BRSK1,SIK2,CRTC2,MYC,HSP90AA1,ESR1,GSK3B,YWHAG,ETV4,TSC1
fcer1pathway	Fc-epsilon receptor I signaling in mast cells	0.160868206242692	-1.82716984399522	58	56	0.0272638753651412	2054	2226	5609,5290,2241,2207,5062,5321,3551,5594,3265,3725,4790,1796,5829,1843,868,2213,5595,2885,9846,5970,7456,5335,4214,5894,6850,2205,5605,3059,5599,6654,8611,5604,8877,2534,1147,3702,5579,867,27040,1901,5319,5921,3937,5295,6464,7409,6416,4067,4773,5338,7462,207,2353,5781,5783,2206	MAP2K7,PIK3CA,FER,FCER1G,PAK2,PLA2G4A,IKBKB,MAPK1,HRAS,JUN,NFKB1,DOK1,PXN,DUSP1,CBLB,FCGR2B,MAPK3,GRB2,GAB2,RELA,WIPF1,PLCG1,MAP3K1,RAF1,SYK,FCER1A,MAP2K2,HCLS1,MAPK8,SOS1,PLPP1,MAP2K1,SPHK1,FYN,CHUK,ITK,PRKCB,CBL,LAT,S1PR1,PLA2G1B,RASA1,LCP2,PIK3R1,SHC1,VAV1,MAP2K4,LYN,NFATC2,PLD2,LAT2,AKT1,FOS,PTPN11,PTPN13,MS4A2
anthraxpathway	Cellular roles of Anthrax toxin	0.16898830769325	-1.77792575169951	22	22	0.0107108081791626	2054	2226	3606,5606,84168,5604,22861,834,5241,7124,5605,801,808,6416,5608,1667,118429,5595,7412,5594,805,728358,3553,5609	IL18,MAP2K3,ANTXR1,MAP2K1,NLRP1,CASP1,PGR,TNF,MAP2K2,CALM1,CALM3,MAP2K4,MAP2K6,DEFA1,ANTXR2,MAPK3,VCAM1,MAPK1,CALM2,DEFA1B,IL1B,MAP2K7
hedgehog_2pathway	Signaling events mediated by the Hedgehog family	0.16898830769325	-1.77792575169951	22	22	0.0107108081791626	2054	2226	50937,64399,6491,3549,6608,207,409,8643,7042,5744,5290,5727,6469,50846,2619,4043,91653,5295,55733,4036,156,2736	CDON,HHIP,STIL,IHH,SMO,AKT1,ARRB2,PTCH2,TGFB2,PTHLH,PIK3CA,PTCH1,SHH,DHH,GAS1,LRPAP1,BOC,PIK3R1,HHAT,LRP2,GRK2,GLI2
ecadherin_stabilization_pathway	Stabilization and expansion of the E-cadherin adherens junction	0.171782730513175	-1.76152479536245	40	39	0.0189873417721519	2054	2226	55740,6810,57662,4646,28964,4026,1500,87,382,999,10006,7414,4633,51474,1956,144100,1495,1950,360,362,10787,3480,3801,4248,1729,11336,26999,1942,1499,4690,60412,3082,4233,7408,387,1969,7791,5819,23396	ENAH,STX4,CAMSAP3,MYO6,GIT1,LPP,CTNND1,ACTN1,ARF6,CDH1,ABI1,VCL,MYL2,LIMA1,EGFR,PLEKHA7,CTNNA1,EGF,AQP3,AQP5,NCKAP1,IGF1R,KIFC3,MGAT3,DIAPH1,EXOC3,CYFIP2,EFNA1,CTNNB1,NCK1,EXOC4,HGF,MET,VASP,RHOA,EPHA2,ZYX,NECTIN2,PIP5K1C
ifngpathway	IFN-gamma pathway	0.171782730513175	-1.76152479536245	40	39	0.0189873417721519	2054	2226	1387,4092,2475,8651,816,3458,5295,5595,3659,1612,1051,5290,3553,10379,815,805,5594,2889,2033,3717,4296,867,80142,5781,3716,834,3459,5604,817,6772,4214,801,51588,6774,818,808,8554,207,5580	CREBBP,SMAD7,MTOR,SOCS1,CAMK2B,IFNG,PIK3R1,MAPK3,IRF1,DAPK1,CEBPB,PIK3CA,IL1B,IRF9,CAMK2A,CALM2,MAPK1,RAPGEF1,EP300,JAK2,MAP3K11,CBL,PTGES2,PTPN11,JAK1,CASP1,IFNGR1,MAP2K1,CAMK2D,STAT1,MAP3K1,CALM1,PIAS4,STAT3,CAMK2G,CALM3,PIAS1,AKT1,PRKCD
trkrpathway	Neurotrophic factor-mediated Trk receptor signaling	0.178985206082198	-1.72045212414237	56	54	0.0262901655306719	2054	2226	53358,23327,5595,7074,55179,1793,5290,2889,5594,6654,4916,5604,595,2549,387,5584,9846,2885,5335,4909,8878,998,4804,1759,6016,10287,5923,391,5058,627,6993,1398,6464,5921,5295,10818,25759,5590,4908,10755,25,9093,5781,4914,23263,30844,5879,4915,4803,4145,9844,10817,6774,6014	SHC3,NEDD4L,MAPK3,TIAM1,FAIM,DOCK1,PIK3CA,RAPGEF1,MAPK1,SOS1,NTRK3,MAP2K1,CCND1,GAB1,RHOA,PRKCI,GAB2,GRB2,PLCG1,NTF4,SQSTM1,CDC42,NGFR,DNM1,RIT1,RGS19,RASGRF1,RHOG,PAK1,BDNF,DYNLT1,CRK,SHC1,RASA1,PIK3R1,FRS2,SHC2,PRKCZ,NTF3,GIPC1,ABL1,DNAJA3,PTPN11,NTRK1,MCF2L,EHD4,RAC1,NTRK2,NGF,MATK,ELMO1,FRS3,STAT3,RIT2
p53downstreampathway	Direct p53 effectors	0.183802875407435	-1.69389142496401	132	125	0.060856864654333	2054	2226	596,7039,355,3976,1820,2876,1907,64065,639,57103,1969,6597,4233,857,55240,4802,10498,333926,9540,9518,5054,1462,3090,25898,624,3064,6667,604,317,324,84883,1387,94241,4313,54487,7306,1847,4800,581,7421,5111,3732,2810,10153,4436,8295,29108,6273,23368,8793,5268,6591,1026,1643,6880,28984,3066,5366,7159,578,133746,58484,255488,64326,467,8795,51065,57060,54541,8794,8812,843,7161,55367,22943,1509,834,1647,6696,27244,1434,50484,3725,5925,174,839,597,27113,4193,8797,8626,5458,1263,2232,900,1843,4292,9448,4801,6890,7832,7249,3486,3169,3663,5457,3276,5371,3082,25946,4170,891,6376,2033,10397,5728,79370,29102,5395,5564,1956,55800,665,7157,7027	BCL2,TGFA,FAS,LIF,ARID3A,GPX1,EDN2,PERP,PRDM1,TIGAR,EPHA2,SMARCA4,MET,CAV1,STEAP3,NFYC,CARM1,PPM1J,TP53I3,GDF15,SERPINE1,VCAN,HIC1,RCHY1,BDKRB2,HTT,SP1,BCL6,APAF1,APC,AIFM2,CREBBP,TP53INP1,MMP2,DGCR8,TYRP1,DUSP5,NFYA,BAX,VDR,PCNA,CD82,SFN,CEBPZ,MSH2,TRRAP,PYCARD,S100A2,PPP1R13B,TNFRSF10D,SERPINB5,SNAI2,CDKN1A,DDB2,TAF9,RGCC,HDAC2,PMAIP1,TP53BP2,BAK1,JMY,NLRC4,RNF144B,COP1,ATF3,TNFRSF10B,RPS27L,PCBP4,DDIT4,TNFRSF10C,CCNK,CASP10,TP73,PIDD1,DKK1,CTSD,CASP1,GADD45A,SPP1,SESN1,CSE1L,RRM2B,JUN,RB1,AFP,CASP6,BCL2A1,BBC3,MDM2,TNFRSF10A,TP63,POU4F2,PLK3,FDXR,CCNG1,DUSP1,MLH1,MAP4K4,NFYB,TAP1,BTG2,TSC2,IGFBP3,FOXA1,IRF5,POU4F1,PRMT1,PML,HGF,ZNF385A,MCL1,CCNB1,CX3CL1,EP300,NDRG1,PTEN,BCL2L14,DROSHA,PMS2,PRKAB1,EGFR,SCN3B,BNIP3L,TP53,TFDP1
erbb1_downstream_pathway	ErbB1 downstream signaling	0.184987221798491	-1.68746852764886	102	97	0.0472249269717624	2054	2226	5601,6772,5518,2353,10092,4086,5879,10109,6416,9712,10971,5295,79109,1956,7532,1958,10006,4609,7410,5590,5604,6714,10096,2549,5536,824,5515,5599,5605,2885,4214,998,5868,10787,7533,10458,7529,1843,5900,5291,253260,55845,3725,8976,6194,2059,5607,81624,2810,10097,5898,26999,5580,1386,5338,9610,207,9252,6548,10094,6774,1950,378,10095,64223,2475,8986,7534,5598,8826,805,5520,1124,2151,10093,9047,1385,10746,5170,6654,10163,5894,801,5578,808,5595,7531,4208,673,466,5594,5037,6722,5337,7538,1848,5290	MAPK9,STAT1,PPP2R1A,FOS,ARPC5,SMAD1,RAC1,ARPC2,MAP2K4,USP6NL,YWHAQ,PIK3R1,MAPKAP1,EGFR,YWHAG,EGR1,ABI1,MYC,VAV2,PRKCZ,MAP2K1,SRC,ACTR3,GAB1,PPP5C,CAPN2,PPP2CA,MAPK8,MAP2K2,GRB2,MAP3K1,CDC42,RAB5A,NCKAP1,YWHAH,BAIAP2,YWHAB,DUSP1,RALGDS,PIK3CB,RICTOR,BRK1,JUN,WASL,RPS6,EPS8,MAP2K5,DIAPH3,SFN,ACTR2,RALA,CYFIP2,PRKCD,ATF2,PLD2,RIN1,AKT1,RPS6KA5,SLC9A1,ARPC3,STAT3,EGF,ARF4,ARPC1B,MLST8,MTOR,RPS6KA4,YWHAZ,MAPK7,IQGAP1,CALM2,PPP2R2A,CHN2,F2RL2,ARPC4,SH2D2A,CREB1,MAP3K2,PDPK1,SOS1,WASF2,RAF1,CALM1,PRKCA,CALM3,MAPK3,YWHAE,MEF2C,BRAF,ATF1,MAPK1,PEBP1,SRF,PLD1,ZFP36,DUSP6,PIK3CA
cdc42_pathway	CDC42 signaling events	0.196456978098785	-1.627311812617	70	67	0.0326192794547225	2054	2226	1495,6198,5295,5058,388585,5923,2475,10095,8826,4296,2932,867,128239,55740,7410,5590,10188,5606,5601,81624,8874,10097,1499,10092,1072,1386,5879,5581,5608,10094,10109,6416,5595,7074,10458,23265,8476,1739,324,673,999,10298,3265,3725,5594,4633,5337,8976,2059,5290,5609,5062,10093,6714,2151,7525,10096,3984,5599,396,9564,5080,5894,1432,998,4214,3985	CTNNA1,RPS6KB1,PIK3R1,PAK1,HES5,RASGRF1,MTOR,ARPC1B,IQGAP1,MAP3K11,GSK3B,CBL,IQGAP3,ENAH,VAV2,PRKCZ,TNK2,MAP2K3,MAPK9,DIAPH3,ARHGEF7,ACTR2,CTNNB1,ARPC5,CFL1,ATF2,RAC1,PRKCE,MAP2K6,ARPC3,ARPC2,MAP2K4,MAPK3,TIAM1,BAIAP2,EXOC7,CDC42BPA,DLG1,APC,BRAF,CDH1,PAK4,HRAS,JUN,MAPK1,MYL2,PLD1,WASL,EPS8,PIK3CA,MAP2K7,PAK2,ARPC4,SRC,F2RL2,YES1,ACTR3,LIMK1,MAPK8,ARHGDIA,BCAR1,PAX6,RAF1,MAPK14,CDC42,MAP3K1,LIMK2
p38_mk2pathway	p38 signaling mediated by MAPKAP kinases	0.198784460513977	-1.61553415424351	20	20	0.00973709834469328	2054	2226	994,3315,7534,4046,7531,7529,7533,10971,1385,2810,7867,2115,7532,5894,6929,1432,7054,9261,7249,6722	CDC25B,HSPB1,YWHAZ,LSP1,YWHAE,YWHAB,YWHAH,YWHAQ,CREB1,SFN,MAPKAPK3,ETV1,YWHAG,RAF1,TCF3,MAPK14,TH,MAPKAPK2,TSC2,SRF
il2_pi3kpathway	IL2 signaling events mediated by PI3K	0.2066357591502	-1.57679765329423	37	36	0.0175267770204479	2054	2226	4790,2475,7357,7015,598,3560,3558,6198,5295,6464,6194,4609,5290,2309,3320,5590,8661,805,6609,1869,3716,259230,5781,3559,6654,3932,2885,9846,5970,5879,801,4602,808,3718,207,596	NFKB1,MTOR,UGCG,TERT,BCL2L1,IL2RB,IL2,RPS6KB1,PIK3R1,SHC1,RPS6,MYC,PIK3CA,FOXO3,HSP90AA1,PRKCZ,EIF3A,CALM2,SMPD1,E2F1,JAK1,SGMS1,PTPN11,IL2RA,SOS1,LCK,GRB2,GAB2,RELA,RAC1,CALM1,MYB,CALM3,JAK3,AKT1,BCL2
smad2_3pathway	Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.215585898945247	-1.53439584586522	19	19	0.00925024342745862	2054	2226	58190,5494,10106,4214,801,51588,808,9972,3838,10217,3837,8021,805,5594,7329,4089,4088,5595,4087	CTDSP1,PPM1A,CTDSP2,MAP3K1,CALM1,PIAS4,CALM3,NUP153,KPNA2,CTDSPL,KPNB1,NUP214,CALM2,MAPK1,UBE2I,SMAD4,SMAD3,MAPK3,SMAD2
ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes	0.215585898945247	-1.53439584586522	19	19	0.00925024342745862	2054	2226	1956,846,208,7791,387,7408,5295,6714,1495,5335,2534,5879,342184,5290,84962,207,1500,999,8394	EGFR,CASR,AKT2,ZYX,RHOA,VASP,PIK3R1,SRC,CTNNA1,PLCG1,FYN,RAC1,FMN1,PIK3CA,AJUBA,AKT1,CTNND1,CDH1,PIP5K1A
il2_1pathway	IL2-mediated signaling events	0.220397475967521	-1.51232265382194	52	50	0.0243427458617332	2054	2226	1154,5290,2185,10254,3725,5594,3667,3558,3560,1017,5595,3458,9846,2885,6776,6850,5894,1432,9261,596,5605,6654,5599,5604,387,2534,4609,9046,5579,8660,5528,8027,6777,8651,6464,5295,5921,5581,8835,6774,3718,3716,5600,5781,3559,2353,9021,5601,6772,3932	CISH,PIK3CA,PTK2B,STAM2,JUN,MAPK1,IRS1,IL2,IL2RB,CDK2,MAPK3,IFNG,GAB2,GRB2,STAT5A,SYK,RAF1,MAPK14,MAPKAPK2,BCL2,MAP2K2,SOS1,MAPK8,MAP2K1,RHOA,FYN,MYC,DOK2,PRKCB,IRS2,PPP2R5D,STAM,STAT5B,SOCS1,SHC1,PIK3R1,RASA1,PRKCE,SOCS2,STAT3,JAK3,JAK1,MAPK11,PTPN11,IL2RA,FOS,SOCS3,MAPK9,STAT1,LCK
tgfbrpathway	TGF-beta receptor signaling	0.23189718875966	-1.46146115743466	51	49	0.0238558909444985	2054	2226	5520,6498,64750,9372,8312,6198,1616,83737,6464,5516,168002,7049,409,25805,1499,6711,4088,54778,5371,23645,1490,7048,815,11059,7046,4092,23327,7531,7040,4089,6885,83658,7043,4087,2280,83939,2885,9765,1601,5515,11171,6654,5170,857,387,10413,100506658,57154,5499	PPP2R2A,SKIL,SMURF2,ZFYVE9,AXIN1,RPS6KB1,DAXX,ITCH,SHC1,PPP2CB,DACT2,TGFBR3,ARRB2,BAMBI,CTNNB1,SPTBN1,SMAD3,RNF111,PML,PPP1R15A,CCN2,TGFBR2,CAMK2A,WWP1,TGFBR1,SMAD7,NEDD4L,YWHAE,TGFB1,SMAD4,MAP3K7,DYNLRB1,TGFB3,SMAD2,FKBP1A,EIF2A,GRB2,ZFYVE16,DAB2,PPP2CA,STRAP,SOS1,PDPK1,CAV1,RHOA,YAP1,OCLN,SMURF1,PPP1CA
erbb2erbb3pathway	ErbB2/ErbB3 signaling events	0.233191478700139	-1.4558953659104	35	34	0.0165530671859786	2054	2226	5290,5291,5594,3725,3717,10193,2475,5566,9542,5595,5295,6464,2885,5602,6774,1145,4776,4771,2064,5894,207,85440,5532,5605,2353,5781,5599,6654,6714,5604,5601,9101,1134,2065	PIK3CA,PIK3CB,MAPK1,JUN,JAK2,RNF41,MTOR,PRKACA,NRG2,MAPK3,PIK3R1,SHC1,GRB2,MAPK10,STAT3,CHRNE,NFATC4,NF2,ERBB2,RAF1,AKT1,DOCK7,PPP3CB,MAP2K2,FOS,PTPN11,MAPK8,SOS1,SRC,MAP2K1,MAPK9,USP8,CHRNA1,ERBB3
bcr_5pathway	BCR signaling pathway	0.23578397545763	-1.44483925138308	66	63	0.0306718597857838	2054	2226	1147,4792,5728,7410,805,5777,6464,5295,5921,5452,2113,5879,1445,818,4067,5788,5532,207,5336,973,2353,5290,8915,597,3551,3725,3265,5594,4790,1796,4793,84433,5595,2213,930,9467,10892,6885,933,5970,55824,2885,808,29760,971,4214,801,6850,5894,1432,11184,974,27071,25998,6654,5170,5599,4772,1457,5604,5530,5533,7189	CHUK,NFKBIA,PTEN,VAV2,CALM2,PTPN6,SHC1,PIK3R1,RASA1,POU2F2,ETS1,RAC1,CSK,CAMK2G,LYN,PTPRC,PPP3CB,AKT1,PLCG2,CD79A,FOS,PIK3CA,BCL10,BCL2A1,IKBKB,JUN,HRAS,MAPK1,NFKB1,DOK1,NFKBIB,CARD11,MAPK3,FCGR2B,CD19,SH3BP5,MALT1,MAP3K7,CD22,RELA,PAG1,GRB2,CALM3,BLNK,CD72,MAP3K1,CALM1,SYK,RAF1,MAPK14,MAP4K1,CD79B,DAPP1,IBTK,SOS1,PDPK1,MAPK8,NFATC1,CSNK2A1,MAP2K1,PPP3CA,PPP3CC,TRAF6
lysophospholipid_pathway	LPA receptor mediated events	0.246511156395781	-1.40034802731146	65	62	0.0301850048685492	2054	2226	1956,54331,836,5295,147,1398,113,9138,2769,2781,4792,2767,2932,108,2353,5331,4318,4067,3569,109,5581,115,10672,5879,207,4313,5580,5338,107,5829,2773,2770,4790,5587,114,5747,7074,2782,2776,2771,2185,3265,3725,4137,5291,1902,111,196883,387,7205,2549,23566,6714,9630,3576,9351,1839,2768,5335,112,5970,9564	EGFR,GNG2,CASP3,PIK3R1,ADRA1B,CRK,ADCY7,ARHGEF1,GNA15,GNAZ,NFKBIA,GNA11,GSK3B,ADCY2,FOS,PLCB3,MMP9,LYN,IL6,ADCY3,PRKCE,ADCY9,GNA13,RAC1,AKT1,MMP2,PRKCD,PLD2,ADCY1,PXN,GNAI3,GNAI1,NFKB1,PRKD1,ADCY8,PTK2,TIAM1,GNB1,GNAQ,GNAI2,PTK2B,HRAS,JUN,MAPT,PIK3CB,LPAR1,ADCY5,ADCY4,RHOA,TRIP6,GAB1,LPAR3,SRC,GNA14,CXCL8,NHERF2,HBEGF,GNA12,PLCG1,ADCY6,RELA,BCAR1
fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2	0.247542862813684	-1.39617152888226	34	33	0.0160662122687439	2054	2226	7392,4772,5329,2697,595,4312,4775,8061,3713,3691,4318,3576,632,3569,3727,4773,3909,4313,3976,7056,1278,5328,4846,9988,3726,890,6667,6347,3162,2033,4256,3725,1634	USF2,NFATC1,PLAUR,GJA1,CCND1,MMP1,NFATC3,FOSL1,IVL,ITGB4,MMP9,CXCL8,BGLAP,IL6,JUND,NFATC2,LAMA3,MMP2,LIF,THBD,COL1A2,PLAU,NOS3,DMTF1,JUNB,CCNA2,SP1,CCL2,HMOX1,EP300,MGP,JUN,DCN
arf6_pathway	Arf6 signaling events	0.247542862813684	-1.39617152888226	34	33	0.0160662122687439	2054	2226	1942,4690,3690,9922,1969,51454,9630,6714,9265,3082,4233,9098,7253,3973,9266,409,23527,5829,1956,9744,1950,154,26034,2776,2769,185,28964,2767,116984,11033,3674,382,23303	EFNA1,NCK1,ITGB3,IQSEC1,EPHA2,GULP1,GNA14,SRC,CYTH3,HGF,MET,USP6,TSHR,LHCGR,CYTH2,ARRB2,ACAP2,PXN,EGFR,ACAP1,EGF,ADRB2,IPCEF1,GNAQ,GNA15,AGTR1,GIT1,GNA11,ARAP2,ADAP1,ITGA2B,ARF6,KIF13B
epha2_fwdpathway	EPHA2 forward signaling	0.253539910888116	-1.37223402894233	17	17	0.00827653359298929	2054	2226	2885,5879,5290,7410,3636,10451,9564,867,5058,2909,1942,6714,7074,387,1969,52,5295	GRB2,RAC1,PIK3CA,VAV2,INPPL1,VAV3,BCAR1,CBL,PAK1,ARHGAP35,EFNA1,SRC,TIAM1,RHOA,EPHA2,ACP1,PIK3R1
ncadherinpathway	N-cadherin signaling events	0.262643254405897	-1.33695861473742	33	32	0.0155793573515093	2054	2226	221955,5599,1499,4041,747,1639,2697,23396,2596,387,22919,808,818,5335,3799,2260,801,5879,5770,2017,2934,5295,8312,1495,2891,5290,2241,4633,805,1268,1000,1500	DAGLB,MAPK8,CTNNB1,LRP5,DAGLA,DCTN1,GJA1,PIP5K1C,GAP43,RHOA,MAPRE1,CALM3,CAMK2G,PLCG1,KIF5B,FGFR1,CALM1,RAC1,PTPN1,CTTN,GSN,PIK3R1,AXIN1,CTNNA1,GRIA2,PIK3CA,FER,MYL2,CALM2,CNR1,CDH2,CTNND1
foxopathway	FoxO family signaling	0.269311971164253	-1.31188482725896	48	46	0.0223953261927945	2054	2226	7763,5602,1647,847,5599,10018,356,1027,2309,8850,7514,1454,3551,6648,7529,1017,1452,7531,1387,2538,7533,604,1455,5901,2308,5934,23411,207,891,6446,1499,5601,2810,114907,7874,4485,1147,1453,1456,5347,7532,2033,53944,7534,10971,6502	ZFAND5,MAPK10,GADD45A,CAT,MAPK8,BCL2L11,FASLG,CDKN1B,FOXO3,KAT2B,XPO1,CSNK1E,IKBKB,SOD2,YWHAB,CDK2,CSNK1A1,YWHAE,CREBBP,G6PC1,YWHAH,BCL6,CSNK1G2,RAN,FOXO1,RBL2,SIRT1,AKT1,CCNB1,SGK1,CTNNB1,MAPK9,SFN,FBXO32,USP7,MST1,CHUK,CSNK1D,CSNK1G3,PLK1,YWHAG,EP300,CSNK1G1,YWHAZ,YWHAQ,SKP2
cd8tcrpathway	TCR signaling in naive CD8+ T cells	0.269311971164253	-1.31188482725896	48	46	0.0223953261927945	2054	2226	10892,5906,919,10125,942,84433,5551,3551,926,8915,941,7189,5170,6654,9402,55824,2885,5335,5578,3105,915,3937,7409,940,27040,83593,5777,867,916,1326,7535,2534,1147,5579,6786,5588,3932,9020,84876,917,5788,207,567,1445,5581,10235	MALT1,RAP1A,CD247,RASGRP1,CD86,CARD11,PRF1,IKBKB,CD8B,BCL10,CD80,TRAF6,PDPK1,SOS1,GRAP2,PAG1,GRB2,PLCG1,PRKCA,HLA-A,CD3D,LCP2,VAV1,CD28,LAT,RASSF5,PTPN6,CBL,CD3E,MAP3K8,ZAP70,FYN,CHUK,PRKCB,STIM1,PRKCQ,LCK,MAP3K14,ORAI1,CD3G,PTPRC,AKT1,B2M,CSK,PRKCE,RASGRP2
pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma	0.278516546102998	-1.2782778098787	32	31	0.0150925024342746	2054	2226	7529,7531,7534,116986,5295,6464,10971,7533,7442,5290,2036,2309,1958,815,7532,2932,6654,5170,7222,814,2810,595,2549,1385,6714,5335,6776,4803,2885,207,5580	YWHAB,YWHAE,YWHAZ,AGAP2,PIK3R1,SHC1,YWHAQ,YWHAH,TRPV1,PIK3CA,EPB41L1,FOXO3,EGR1,CAMK2A,YWHAG,GSK3B,SOS1,PDPK1,TRPC3,CAMK4,SFN,CCND1,GAB1,CREB1,SRC,PLCG1,STAT5A,NGF,GRB2,AKT1,PRKCD
il12_2pathway	IL12-mediated signaling events	0.293124677649703	-1.2271572394847	61	58	0.0282375851996105	2054	2226	5606,6772,3932,1234,3606,6775,8809,3559,2353,8807,1386,567,917,5608,56848,6774,915,3105,8651,7297,4616,2475,8767,10912,916,3565,388372,3001,3554,30009,3123,7879,6351,3593,356,6778,5971,1432,3142,5970,6348,8320,6776,4791,919,3595,3458,920,3002,4790,3122,3558,3560,3592,3594,3717,926,3553	MAP2K3,STAT1,LCK,CCR5,IL18,STAT4,IL18R1,IL2RA,FOS,IL18RAP,ATF2,B2M,CD3G,MAP2K6,SPHK2,STAT3,CD3D,HLA-A,SOCS1,TYK2,GADD45B,MTOR,RIPK2,GADD45G,CD3E,IL4,CCL4L1,GZMA,IL1R1,TBX21,HLA-DRB1,RAB7A,CCL4,IL12B,FASLG,STAT6,RELB,MAPK14,HLX,RELA,CCL3,EOMES,STAT5A,NFKB2,CD247,IL12RB2,IFNG,CD4,GZMB,NFKB1,HLA-DRA,IL2,IL2RB,IL12A,IL12RB1,JAK2,CD8B,IL1B
syndecan_4_pathway	Syndecan-4-mediated signaling events	0.295185364986571	-1.22015176408854	31	30	0.0146056475170399	2054	2226	7035,3688,8038,87,10755,7852,23495,2335,4192,7057,84309,6387,284217,6352,2260,5578,5879,3909,6386,8324,1785,5580,2251,2247,5340,387,3371,2147,4318,6385	TFPI,ITGB1,ADAM12,ACTN1,GIPC1,CXCR4,TNFRSF13B,FN1,MDK,THBS1,NUDT16L1,CXCL12,LAMA1,CCL5,FGFR1,PRKCA,RAC1,LAMA3,SDCBP,FZD7,DNM2,PRKCD,FGF6,FGF2,PLG,RHOA,TNC,F2,MMP9,SDC4
arf6downstreampathway	Arf6 downstream pathway	0.298130181280863	-1.2102250379321	15	15	0.00730282375851996	2054	2226	382,8766,8394,5338,5594,5337,5879,8997,5595,7074,375,387,4830,9727,5329	ARF6,RAB11A,PIP5K1A,PLD2,MAPK1,PLD1,RAC1,KALRN,MAPK3,TIAM1,ARF1,RHOA,NME1,RAB11FIP3,PLAUR
tcr_pathway	TCR signaling in naive CD4+ T cells	0.305715414875169	-1.18510062651147	60	57	0.0277507302823759	2054	2226	942,3122,84433,5906,10125,919,10892,920,8915,2533,3551,5170,6654,941,7189,55824,2885,9846,5578,998,5335,11184,84174,9402,6452,940,5777,83593,915,27347,7409,6464,3937,1147,2534,7535,3123,1326,5579,3702,5728,916,867,9020,5781,28988,84876,4690,5588,6786,3932,5581,1445,10235,207,917,5788	CD86,HLA-DRA,CARD11,RAP1A,RASGRP1,CD247,MALT1,CD4,BCL10,FYB1,IKBKB,PDPK1,SOS1,CD80,TRAF6,PAG1,GRB2,GAB2,PRKCA,CDC42,PLCG1,MAP4K1,SLA2,GRAP2,SH3BP2,CD28,PTPN6,RASSF5,CD3D,STK39,VAV1,SHC1,LCP2,CHUK,FYN,ZAP70,HLA-DRB1,MAP3K8,PRKCB,ITK,PTEN,CD3E,CBL,MAP3K14,PTPN11,DBNL,ORAI1,NCK1,PRKCQ,STIM1,LCK,PRKCE,CSK,RASGRP2,AKT1,CD3G,PTPRC
nfkappabatypicalpathway	Atypical NF-kappaB pathway	0.323266647545353	-1.12927776212928	14	14	0.0068159688412853	2054	2226	8945,4790,6714,5295,3932,5290,5970,4792,602,6850,3551,1432,5966,409	BTRC,NFKB1,SRC,PIK3R1,LCK,PIK3CA,RELA,NFKBIA,BCL3,SYK,IKBKB,MAPK14,REL,ARRB2
hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins	0.326282927252383	-1.11999039899388	44	42	0.0204479065238559	2054	2226	26160,1455,3066,51684,9788,5566,8819,2782,51715,1387,2736,1452,54331,53944,8945,23309,2932,1454,1456,3065,5928,10284,7514,1453,3958,2735,11127,5604,27148,3170,25942,8405,8554,409,207,6608,2737,5580,8100,6469,23291,5727	IFT172,CSNK1G2,HDAC2,SUFU,MTSS1,PRKACA,SAP30,GNB1,RAB23,CREBBP,GLI2,CSNK1A1,GNG2,CSNK1G1,BTRC,SIN3B,GSK3B,CSNK1E,CSNK1G3,HDAC1,RBBP4,SAP18,XPO1,CSNK1D,LGALS3,GLI1,KIF3A,MAP2K1,STK36,FOXA2,SIN3A,SPOP,PIAS1,ARRB2,AKT1,SMO,GLI3,PRKCD,IFT88,SHH,FBXW11,PTCH1
reelinpathway	Reelin signaling pathway	0.330991458708157	-1.1056627084451	29	28	0.0136319376825706	2054	2226	4131,5599,4043,1600,5649,9479,2903,2904,5048,207,8440,9181,5295,3675,7436,5906,5609,5290,2534,8851,2932,867,4296,1020,7804,4137,3688,2889	MAP1B,MAPK8,LRPAP1,DAB1,RELN,MAPK8IP1,GRIN2A,GRIN2B,PAFAH1B1,AKT1,NCK2,ARHGEF2,PIK3R1,ITGA3,VLDLR,RAP1A,MAP2K7,PIK3CA,FYN,CDK5R1,GSK3B,CBL,MAP3K11,CDK5,LRP8,MAPT,ITGB1,RAPGEF1
p38_mkk3_6pathway	p38 MAPK signaling pathway	0.330991458708157	-1.1056627084451	29	28	0.0136319376825706	2054	2226	5600,4215,1647,10454,5606,7295,51347,7189,472,5879,5608,4216,4214,23118,801,808,57551,9064,1432,4616,4217,83605,6885,816,9344,4294,10912,805	MAPK11,MAP3K3,GADD45A,TAB1,MAP2K3,TXN,TAOK3,TRAF6,ATM,RAC1,MAP2K6,MAP3K4,MAP3K1,TAB2,CALM1,CALM3,TAOK1,MAP3K6,MAPK14,GADD45B,MAP3K5,CCM2,MAP3K7,CAMK2B,TAOK2,MAP3K10,GADD45G,CALM2
mapktrkpathway	Trk receptor signaling mediated by the MAPK pathway	0.330991458708157	-1.1056627084451	29	28	0.0136319376825706	2054	2226	5595,5598,4208,6195,8851,1020,673,6722,1958,5594,5607,4908,7442,5604,30844,5606,1385,10746,23623,2353,5894,5580,6016,9261,1432,6014,5608,9252	MAPK3,MAPK7,MEF2C,RPS6KA1,CDK5R1,CDK5,BRAF,SRF,EGR1,MAPK1,MAP2K5,NTF3,TRPV1,MAP2K1,EHD4,MAP2K3,CREB1,MAP3K2,RUSC1,FOS,RAF1,PRKCD,RIT1,MAPKAPK2,MAPK14,RIT2,MAP2K6,RPS6KA5
met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.33420441177416	-1.0960024619081	72	68	0.0331061343719572	2054	2226	2549,387,4233,84335,6714,2151,5604,5170,6654,5599,208,57610,5605,5894,9564,5335,5868,998,4214,5770,57521,2885,9846,1977,50649,5595,324,5829,8976,6456,3725,3265,2889,5795,10298,5594,999,5062,9146,5290,1978,3082,64798,4690,1499,5781,10048,3837,207,54453,6416,5879,2060,1398,5295,2113,1495,8650,64223,2475,8440,5058,1958,200958,382,6615,867,3636	GAB1,RHOA,MET,AKT1S1,SRC,F2RL2,MAP2K1,PDPK1,SOS1,MAPK8,AKT2,RANBP10,MAP2K2,RAF1,BCAR1,PLCG1,RAB5A,CDC42,MAP3K1,PTPN1,RPTOR,GRB2,GAB2,EIF4E,ARHGEF4,MAPK3,APC,PXN,WASL,SH3GL2,JUN,HRAS,RAPGEF1,PTPRJ,PAK4,MAPK1,CDH1,PAK2,HGS,PIK3CA,EIF4EBP1,HGF,DEPTOR,NCK1,CTNNB1,PTPN11,RANBP9,KPNB1,AKT1,RIN2,MAP2K4,RAC1,EPS15,CRK,PIK3R1,ETS1,CTNNA1,NUMB,MLST8,MTOR,NCK2,PAK1,EGR1,MUC20,ARF6,SNAI1,CBL,INPPL1
s1p_s1p3_pathway	S1P3 pathway	0.350164008100441	-1.04935363968214	28	27	0.0131450827653359	2054	2226	2321,6714,9294,7422,9630,387,3690,5159,10000,207,10672,5879,2768,2771,5595,2776,1903,2770,2773,1901,7852,3717,5594,2767,3685,2781,2769	FLT1,SRC,S1PR2,VEGFA,GNA14,RHOA,ITGB3,PDGFRB,AKT3,AKT1,GNA13,RAC1,GNA12,GNAI2,MAPK3,GNAQ,S1PR3,GNAI1,GNAI3,S1PR1,CXCR4,JAK2,MAPK1,GNA11,ITGAV,GNAZ,GNA15
tcrcalciumpathway	Calcium signaling in the CD4+ TCR pathway	0.350164008100441	-1.04935363968214	28	27	0.0131450827653359	2054	2226	4772,2353,3559,4775,8061,356,23523,808,801,4773,11261,9495,10231,5743,3558,2280,3458,3726,5566,1827,55509,3562,5451,1437,805,3725,3565	NFATC1,FOS,IL2RA,NFATC3,FOSL1,FASLG,CABIN1,CALM3,CALM1,NFATC2,CHP1,AKAP5,RCAN2,PTGS2,IL2,FKBP1A,IFNG,JUNB,PRKACA,RCAN1,BATF3,IL3,POU2F1,CSF2,CALM2,JUN,IL4
wnt_signaling_pathway	Wnt signaling network	0.350164008100441	-1.04935363968214	28	27	0.0131450827653359	2054	2226	7473,7855,11197,284654,4920,2535,83999,7474,7476,7471,3487,7472,79412,4040,6259,22943,8325,4041,8322,8324,8326,8321,7477,89780,115908,8323,11211	WNT3,FZD5,WIF1,RSPO1,ROR2,FZD2,KREMEN1,WNT5A,WNT7A,WNT1,IGFBP4,WNT2,KREMEN2,LRP6,RYK,DKK1,FZD8,LRP5,FZD4,FZD7,FZD9,FZD1,WNT7B,WNT3A,CTHRC1,FZD6,FZD10
erbb_network_pathway	ErbB receptor signaling network	0.350509108779444	-1.0483685848867	13	13	0.00632911392405063	2054	2226	3320,374,1839,1956,10718,2069,685,7039,145957,1950,2065,2064,9542	HSP90AA1,AREG,HBEGF,EGFR,NRG3,EREG,BTC,TGFA,NRG4,EGF,ERBB3,ERBB2,NRG2
atf2_pathway	ATF-2 transcription factor network	0.374270300646933	-0.982777013607947	55	52	0.0253164556962025	2054	2226	1385,595,11221,3576,5599,383,1647,467,1432,7054,9555,596,3280,5578,3727,3458,5595,890,1843,5328,1019,3725,5594,6401,5156,5451,865,5601,9021,43,8452,10856,8739,2353,10891,672,5600,255631,4313,1850,1386,3569,1847,1466,3726,3630,2033,7042,122953,5268,4763,10524	CREB1,CCND1,DUSP10,CXCL8,MAPK8,ARG1,GADD45A,ATF3,MAPK14,TH,MACROH2A1,BCL2,HES1,PRKCA,JUND,IFNG,MAPK3,CCNA2,DUSP1,PLAU,CDK4,JUN,MAPK1,SELE,PDGFRA,POU2F1,CBFB,MAPK9,SOCS3,ACHE,CUL3,RUVBL2,HRK,FOS,PPARGC1A,BRCA1,MAPK11,COL24A1,MMP2,DUSP8,ATF2,IL6,DUSP5,CSRP2,JUNB,INS,EP300,TGFB2,JDP2,SERPINB5,NF1,KAT5
rac1_pathway	RAC1 signaling pathway	0.389075635817089	-0.94398151771624	54	51	0.0248296007789679	2054	2226	10093,10096,10152,3984,5599,10163,396,9564,1535,1432,6776,10787,4214,10458,29127,999,55845,3725,5609,8936,5062,5330,5601,5606,23396,8395,26999,10097,10092,1499,1072,1386,8394,653361,5879,5608,6774,6416,10094,10109,1495,1398,10095,5058,124056,4688,8826,4296,10006,128239,394	ARPC4,ACTR3,ABI2,LIMK1,MAPK8,WASF2,ARHGDIA,BCAR1,CYBA,MAPK14,STAT5A,NCKAP1,MAP3K1,BAIAP2,RACGAP1,CDH1,BRK1,JUN,MAP2K7,WASF1,PAK2,PLCB2,MAPK9,MAP2K3,PIP5K1C,PIP5K1B,CYFIP2,ACTR2,ARPC5,CTNNB1,CFL1,ATF2,PIP5K1A,NCF1,RAC1,MAP2K6,STAT3,MAP2K4,ARPC3,ARPC2,CTNNA1,CRK,ARPC1B,PAK1,NOXO1,NCF2,IQGAP1,MAP3K11,ABI1,IQGAP3,ARHGAP5
pdgfrbpathway	PDGFR-beta signaling pathway	0.389075635817089	-0.94398151771624	54	51	0.0248296007789679	2054	2226	1796,6461,5290,2241,6503,3091,2887,5795,3265,9368,6654,9351,7525,6714,52,2549,5770,2885,6776,5335,9564,640,8440,1901,6777,10603,5921,5295,6464,5155,4609,8877,2534,5728,7410,867,25,5159,4690,5781,2268,6772,3932,1445,5879,6774,4035,4067,5580,1785,207	DOK1,SHB,PIK3CA,FER,SLA,HIF1A,GRB10,PTPRJ,HRAS,NHERF1,SOS1,NHERF2,YES1,SRC,ACP1,GAB1,PTPN1,GRB2,STAT5A,PLCG1,BCAR1,BLK,NCK2,S1PR1,STAT5B,SH2B2,RASA1,PIK3R1,SHC1,PDGFB,MYC,SPHK1,FYN,PTEN,VAV2,CBL,ABL1,PDGFRB,NCK1,PTPN11,FGR,STAT1,LCK,CSK,RAC1,STAT3,LRP1,LYN,PRKCD,DNM2,AKT1
glypican_1pathway	Glypican 1 network	0.391113713049285	-0.938756935065512	26	25	0.0121713729308666	2054	2226	2817,7048,351,5320,2534,4087,7043,284217,7040,462,7046,640,6997,3084,2260,4067,2247,3932,2321,7525,5621,7422,6714,9353,2268	GPC1,TGFBR2,APP,PLA2G2A,FYN,SMAD2,TGFB3,LAMA1,TGFB1,SERPINC1,TGFBR1,BLK,CRIPTO,NRG1,FGFR1,LYN,FGF2,LCK,FLT1,YES1,PRNP,VEGFA,SRC,SLIT2,FGR
er_nongenomic_pathway	Plasma membrane estrogen receptor signaling	0.391113713049285	-0.938756935065512	26	25	0.0121713729308666	2054	2226	387,6714,4318,5330,6654,5331,23236,5600,2100,207,27043,4313,9564,1839,3480,6801,2885,10672,5295,2782,54331,4846,9475,2099,5290	RHOA,SRC,MMP9,PLCB2,SOS1,PLCB3,PLCB1,MAPK11,ESR2,AKT1,PELP1,MMP2,BCAR1,HBEGF,IGF1R,STRN,GRB2,GNA13,PIK3R1,GNB1,GNG2,NOS3,ROCK2,ESR1,PIK3CA
myc_activpathway	Validated targets of C-MYC transcriptional activation	0.393776195408884	-0.931972563032622	81	76	0.0370009737098345	2054	2226	8607,11235,7037,92140,332,86,6470,389421,2023,5274,661,1981,2597,1104,4869,3320,9913,7083,1965,3398,1019,1387,790,4089,586,1977,7343,5757,654364,10935,8886,6513,894,3658,23089,581,6135,80177,91942,891,8464,3329,993,3159,4318,4088,8295,10856,83879,4691,8061,6875,6880,3811,4609,10524,57678,648,6883,6615,6881,4149,2033,4953,84864,7015,1871,7157,5292,4831,3308,5366,100532731,3939,4683,4830	RUVBL1,PDCD10,TFRC,MTDH,BIRC5,ACTL6A,SHMT1,LIN28B,ENO1,SERPINI1,POLR3D,EIF4G1,GAPDH,RCC1,NPM1,HSP90AA1,SUPT7L,TK1,EIF2S1,ID2,CDK4,CREBBP,CAD,SMAD4,BCAT1,EIF4E,UBTF,PTMA,NME1-NME2,PRDX3,DDX18,SLC2A1,CCND2,IREB2,PEG10,BAX,RPL11,MYCT1,NDUFAF2,CCNB1,SUPT3H,HSPD1,CDC25A,HMGA1,MMP9,SMAD3,TRRAP,RUVBL2,CDCA7,NCL,FOSL1,TAF4B,TAF9,KIR3DL1,MYC,KAT5,GPAM,BMI1,TAF12,SNAI1,TAF10,MAX,EP300,ODC1,RIOX2,TERT,E2F3,TP53,PIM1,NME2,HSPA4,PMAIP1,COMMD3-BMI1,LDHA,NBN,NME1
rac1_reg_pathway	Regulation of RAC1 activity	0.409146181508192	-0.893682774795321	39	37	0.0180136319376826	2054	2226	5879,9844,7204,396,80243,10928,57572,6654,392,57580,64333,26230,115557,5910,55114,8874,221178,8997,2059,1124,7410,10451,1123,10006,5923,29127,1794,9181,25791,7074,4830,5924,50619,613,7409,29,1793	RAC1,ELMO1,TRIO,ARHGDIA,PREX2,RALBP1,DOCK6,SOS1,ARHGAP1,PREX1,ARHGAP9,TIAM2,ARHGEF25,RAP1GDS1,ARHGAP17,ARHGEF7,SPATA13,KALRN,EPS8,CHN2,VAV2,VAV3,CHN1,ABI1,RASGRF1,RACGAP1,DOCK2,ARHGEF2,NGEF,TIAM1,NME1,RASGRF2,DEF6,BCR,VAV1,ABR,DOCK1
aurora_b_pathway	Aurora B signaling	0.409146181508192	-0.893682774795321	39	37	0.0180136319376826	2054	2226	387,4691,9493,8452,10403,10592,10051,699,23468,23397,55958,1731,332,3619,7813,10112,9918,6790,5921,7431,1058,4638,151648,11004,5684,29127,64151,5528,5037,6867,3925,5501,9212,4869,54888,1674,6795	RHOA,NCL,KIF23,CUL3,NDC80,SMC2,SMC4,BUB1,CBX5,NCAPH,KLHL9,SEPTIN1,BIRC5,INCENP,EVI5,KIF20A,NCAPD2,AURKA,RASA1,VIM,CENPA,MYLK,SGO1,KIF2C,PSMA3,RACGAP1,NCAPG,PPP2R5D,PEBP1,TACC1,STMN1,PPP1CC,AURKB,NPM1,NSUN2,DES,AURKC
alk2pathway	ALK2 signaling events	0.412027830283449	-0.886664382682284	11	11	0.0053554040895813	2054	2226	3196,90,4089,269,2280,4086,659,4093,268,4090,655	TLX2,ACVR1,SMAD4,AMHR2,FKBP1A,SMAD1,BMPR2,SMAD9,AMH,SMAD5,BMP7
ranbp2pathway	Sumoylation by RanBP2 regulates transcriptional repression	0.412027830283449	-0.886664382682284	11	11	0.0053554040895813	2054	2226	5901,8554,3065,5905,7514,9063,7329,9759,4193,7341,5903	RAN,PIAS1,HDAC1,RANGAP1,XPO1,PIAS2,UBE2I,HDAC4,MDM2,SUMO1,RANBP2
telomerasepathway	Regulation of Telomerase	0.412782460939397	-0.884834553751832	66	62	0.0301850048685492	2054	2226	26277,4691,4088,2353,207,3183,7490,7520,10728,4683,3066,1950,65057,6198,1956,7015,2475,3455,23309,4149,7486,5810,6670,5883,25,8658,10284,2099,5928,641,7014,4609,472,595,1027,25913,2547,23381,10038,25942,7026,7337,4084,3458,3364,4361,5595,6667,7040,8819,3558,7531,4790,1869,3725,5594,3065,7013,10111,3320,3659,23293	TINF2,NCL,SMAD3,FOS,AKT1,HNRNPC,WT1,XRCC5,PTGES3,NBN,HDAC2,EGF,ACD,RPS6KB1,EGFR,TERT,MTOR,IFNAR2,SIN3B,MAX,WRN,RAD1,SP3,RAD9A,ABL1,TNKS,SAP18,ESR1,RBBP4,BLM,TERF2,MYC,ATM,CCND1,CDKN1B,POT1,XRCC6,SMG5,PARP2,SIN3A,NR2F2,UBE3A,MXD1,IFNG,HUS1,MRE11,MAPK3,SP1,TGFB1,SAP30,IL2,YWHAE,NFKB1,E2F1,JUN,MAPK1,HDAC1,TERF1,RAD50,HSP90AA1,IRF1,SMG6
erbb1_receptor_proximal_pathway	EGF receptor (ErbB1) signaling pathway	0.412905427793042	-0.88453670063752	25	24	0.0116845180136319	2054	2226	5770,2885,5335,6774,6654,5781,6772,6714,2549,23396,5290,5291,8976,5594,2770,5058,2773,1956,5777,2934,5595,5921,5295,1950	PTPN1,GRB2,PLCG1,STAT3,SOS1,PTPN11,STAT1,SRC,GAB1,PIP5K1C,PIK3CA,PIK3CB,WASL,MAPK1,GNAI1,PAK1,GNAI3,EGFR,PTPN6,GSN,MAPK3,RASA1,PIK3R1,EGF
kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)	0.41972583105146	-0.868153564071261	52	49	0.0238558909444985	2054	2226	26228,4145,4067,4286,6774,207,5781,2056,6772,6591,5728,2932,867,4254,5777,10603,5287,6198,8651,7409,5295,6464,2885,5800,6776,5894,9402,11184,596,5605,161742,5599,5170,6654,5604,2549,2241,5290,2309,10019,2057,2887,3265,3717,1796,1387,3815,200734,5595	STAP1,MATK,LYN,MITF,STAT3,AKT1,PTPN11,EPO,STAT1,SNAI2,PTEN,GSK3B,CBL,KITLG,PTPN6,SH2B2,PIK3C2B,RPS6KB1,SOCS1,VAV1,PIK3R1,SHC1,GRB2,PTPRO,STAT5A,RAF1,GRAP2,MAP4K1,BCL2,MAP2K2,SPRED1,MAPK8,PDPK1,SOS1,MAP2K1,GAB1,FER,PIK3CA,FOXO3,SH2B3,EPOR,GRB10,HRAS,JAK2,DOK1,CREBBP,KIT,SPRED2,MAPK3
ret_pathway	Signaling events regulated by Ret tyrosine kinase	0.427238471827984	-0.850412939613815	38	36	0.0175267770204479	2054	2226	5879,2885,9260,5578,55816,220164,9564,6654,4690,5599,5781,6714,2549,2674,387,1385,5290,2668,8660,2887,3265,3725,5594,1796,3667,5979,55715,5829,5595,5566,6464,1398,10818,5295,5921,5906	RAC1,GRB2,PDLIM7,PRKCA,DOK5,DOK6,BCAR1,SOS1,NCK1,MAPK8,PTPN11,SRC,GAB1,GFRA1,RHOA,CREB1,PIK3CA,GDNF,IRS2,GRB10,HRAS,JUN,MAPK1,DOK1,IRS1,RET,DOK4,PXN,MAPK3,PRKACA,SHC1,CRK,FRS2,PIK3R1,RASA1,RAP1A
cmyb_pathway	C-MYB transcription factor network	0.431900366216557	-0.839560351096051	78	73	0.0355404089581305	2054	2226	947,28996,4602,9611,4069,330,1211,5743,5481,4144,891,3015,27044,4173,1436,8089,490,161882,4654,3312,5250,4609,1021,1026,8535,2033,4254,4618,8826,759,5292,7329,2625,2113,1052,51176,4893,171558,100,8379,596,3280,1278,6497,25942,8900,136,595,1027,5530,22797,5079,5657,6688,4353,10043,1051,4094,290,1050,839,3815,6595,5897,1387,1991,2944,7471,2114,3950,920,6885,6667	CD34,HIPK2,MYB,NCOR1,LYZ,BIRC3,CLTA,PTGS2,PPID,MAT2A,CCNB1,H2AZ1,SND1,MCM4,CSF1R,YEATS4,ATP2B1,ZFPM1,MYOD1,HSPA8,SLC25A3,MYC,CDK6,CDKN1A,CBX4,EP300,KITLG,MYF6,IQGAP1,CA1,PIM1,UBE2I,GATA3,ETS1,CEBPD,LEF1,NRAS,PTCRA,ADA,MAD1L1,BCL2,HES1,COL1A2,SKI,SIN3A,CCNA1,ADORA2B,CCND1,CDKN1B,PPP3CA,TFEC,PAX5,PRTN3,SPI1,MPO,TOM1,CEBPB,MAF,ANPEP,CEBPA,CASP6,KIT,SMARCA2,RAG2,CREBBP,ELANE,GSTM1,WNT1,ETS2,LECT2,CD4,MAP3K7,SP1
wnt_beta_catenin_pathway	Regulation of Wnt-mediated beta catenin signaling and target gene transcription	0.431900366216557	-0.839560351096051	78	73	0.0355404089581305	2054	2226	7514,6925,1462,10499,166,6500,3725,999,3065,8313,324,7529,7531,3398,9314,4762,8945,7088,80333,1857,83439,7533,389058,4617,57680,7091,25776,595,1044,6597,22943,79718,4656,3576,6591,3491,4609,2033,3848,7532,7534,7015,5308,607,1487,26959,3066,10642,8913,51176,10971,113,4286,894,8454,4313,6862,29969,3619,6934,1499,6932,56998,814,2810,7089,57167,8295,10856,23043,2249,27121,4318	XPO1,TCF4,VCAN,NCOA2,TLE5,SKP1,JUN,CDH1,HDAC1,AXIN2,APC,YWHAB,YWHAE,ID2,KLF4,NEUROG1,BTRC,TLE1,KCNIP4,DVL3,TCF7L1,YWHAH,SP5,MYF5,CHD8,TLE4,CBY1,CCND1,CDX1,SMARCA4,DKK1,TBL1XR1,MYOG,CXCL8,SNAI2,CCN1,MYC,EP300,KRT1,YWHAG,YWHAZ,TERT,PITX2,BCL9,CTBP1,HBP1,HDAC2,IGF2BP1,CACNA1G,LEF1,YWHAQ,ADCY7,MITF,CCND2,CUL1,MMP2,TBXT,MDFIC,INCENP,TCF7L2,CTNNB1,TCF7,CTNNBIP1,CAMK4,SFN,TLE2,SALL4,TRRAP,RUVBL2,TNIK,FGF4,DKK4,MMP9
p38gammadeltapathway	Signaling mediated by p38-gamma and p38-delta	0.446699448096378	-0.805869286137749	10	10	0.00486854917234664	2054	2226	6640,5608,5603,51776,5585,5606,595,6300,3925,29904	SNTA1,MAP2K6,MAPK13,MAP3K20,PKN1,MAP2K3,CCND1,MAPK12,STMN1,EEF2K
caspase_pathway	Caspase cascade in apoptosis	0.451689768241957	-0.794759688245263	50	47	0.0228821811100292	2054	2226	4001,5551,839,397,2620,4000,840,6304,1676,8738,317,4926,7431,3002,142,56616,596,7124,329,8717,7150,4214,7020,1073,55367,843,834,3984,7132,3875,835,8567,351,842,6720,836,58,84823,2934,6709,841,330,54205,581,1677,837,8737	LMNB1,PRF1,CASP6,ARHGDIB,GAS2,LMNA,CASP7,SATB1,DFFA,CRADD,APAF1,NUMA1,VIM,GZMB,PARP1,DIABLO,BCL2,TNF,BIRC2,TRADD,TOP1,MAP3K1,TFAP2A,CFL2,PIDD1,CASP10,CASP1,LIMK1,TNFRSF1A,KRT18,CASP2,MADD,APP,CASP9,SREBF1,CASP3,ACTA1,LMNB2,GSN,SPTAN1,CASP8,BIRC3,CYCS,BAX,DFFB,CASP4,RIPK1
cd8tcrdownstreampathway	Downstream signaling in naive CD8+ T cells	0.451689768241957	-0.794759688245263	50	47	0.0228821811100292	2054	2226	4772,5599,5778,356,4775,3604,5604,5578,801,8320,808,7293,7124,5605,5894,3558,3560,8784,3002,919,3458,5595,3725,5594,926,673,5551,3559,2353,6775,8061,5601,5588,4773,5581,567,917,3455,915,3105,3726,5579,1961,3454,805,1958,916	NFATC1,MAPK8,PTPN7,FASLG,NFATC3,TNFRSF9,MAP2K1,PRKCA,CALM1,EOMES,CALM3,TNFRSF4,TNF,MAP2K2,RAF1,IL2,IL2RB,TNFRSF18,GZMB,CD247,IFNG,MAPK3,JUN,MAPK1,CD8B,BRAF,PRF1,IL2RA,FOS,STAT4,FOSL1,MAPK9,PRKCQ,NFATC2,PRKCE,B2M,CD3G,IFNAR2,CD3D,HLA-A,JUNB,PRKCB,EGR4,IFNAR1,CALM2,EGR1,CD3E
rhodopsin_pathway	Visual signal transduction: Rods	0.459120683516438	-0.778442176429789	23	22	0.0107108081791626	2054	2226	5158,6295,145226,2782,388531,2978,9227,3000,6121,9626,2792,1259,5145,2979,2779,6010,5959,10681,9187,5148,8787,6011	PDE6B,SAG,RDH12,GNB1,RGS9BP,GUCA1A,LRAT,GUCY2D,RPE65,GUCA1C,GNGT1,CNGA1,PDE6A,GUCA1B,GNAT1,RHO,RDH5,GNB5,SLC24A1,PDE6G,RGS9,GRK1
nfkappabcanonicalpathway	Canonical NF-kappaB pathway	0.459120683516438	-0.778442176429789	23	22	0.0107108081791626	2054	2226	7124,3551,329,7132,23085,4792,7514,8915,5578,7323,1147,5970,472,7189,5901,10892,1540,7128,8767,8945,4790,64127	TNF,IKBKB,BIRC2,TNFRSF1A,ERC1,NFKBIA,XPO1,BCL10,PRKCA,UBE2D3,CHUK,RELA,ATM,TRAF6,RAN,MALT1,CYLD,TNFAIP3,RIPK2,BTRC,NFKB1,NOD2
bmppathway	BMP receptor signaling	0.464853997016047	-0.76603190761009	36	34	0.0165530671859786	2054	2226	5594,285704,4091,2932,10217,10468,5494,4090,23645,9241,197,58190,4093,6885,4089,654,25928,64750,4092,8021,9765,655,10106,4086,659,8646,148738,56963,5499,57154,26585,6497,9350,25805	MAPK1,RGMB,SMAD6,GSK3B,CTDSPL,FST,PPM1A,SMAD5,PPP1R15A,NOG,AHSG,CTDSP1,SMAD9,MAP3K7,SMAD4,BMP6,SOSTDC1,SMURF2,SMAD7,NUP214,ZFYVE16,BMP7,CTDSP2,SMAD1,BMPR2,CHRD,HJV,RGMA,PPP1CA,SMURF1,GREM1,SKI,CER1,BAMBI
a4b1_paxindep_pathway	Paxillin-independent events mediated by a4b1 and a4b7	0.483524341294391	-0.726653621417241	22	21	0.0102239532619279	2054	2226	1398,5295,1793,387,8174,6714,2056,5829,7412,3688,3717,3695,960,382,3676,867,9564,28964,2057,5879,5290	CRK,PIK3R1,DOCK1,RHOA,MADCAM1,SRC,EPO,PXN,VCAM1,ITGB1,JAK2,ITGB7,CD44,ARF6,ITGA4,CBL,BCAR1,GIT1,EPOR,RAC1,PIK3CA
myc_pathway	C-MYC pathway	0.483524341294391	-0.726653621417241	22	21	0.0102239532619279	2054	2226	26959,5525,8312,8295,6502,10856,5515,8464,4149,86,6881,2932,9913,6883,5062,10524,4609,8607,7709,6880,5300	HBP1,PPP2R5A,AXIN1,TRRAP,SKP2,RUVBL2,PPP2CA,SUPT3H,MAX,ACTL6A,TAF10,GSK3B,SUPT7L,TAF12,PAK2,KAT5,MYC,RUVBL1,ZBTB17,TAF9,PIN1
hivnefpathway	HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.48434070068427	-0.724966692872316	35	33	0.0160662122687439	2054	2226	839,9530,7132,835,8837,1147,5609,1676,842,4792,840,317,1616,8738,4217,919,836,4790,8772,7185,355,8717,596,330,7124,841,5970,54205,1677,356,8737,9020,5599	CASP6,BAG4,TNFRSF1A,CASP2,CFLAR,CHUK,MAP2K7,DFFA,CASP9,NFKBIA,CASP7,APAF1,DAXX,CRADD,MAP3K5,CD247,CASP3,NFKB1,FADD,TRAF1,FAS,TRADD,BCL2,BIRC3,TNF,CASP8,RELA,CYCS,DFFB,FASLG,RIPK1,MAP3K14,MAPK8
nfat_tfpathway	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	0.48485550366978	-0.723904363012559	48	45	0.0219084712755599	2054	2226	5770,801,808,2635,1959,7124,3662,1606,4772,3576,356,4775,5451,1493,55509,5468,3725,1869,4094,1437,1019,3558,868,3458,3567,4773,5743,3559,2353,5588,8061,30009,3562,1961,3565,1960,805,1958,6520,10320,5796,3726,836,2625,83737	PTPN1,CALM1,CALM3,GBP3,EGR2,TNF,IRF4,DGKA,NFATC1,CXCL8,FASLG,NFATC3,POU2F1,CTLA4,BATF3,PPARG,JUN,E2F1,MAF,CSF2,CDK4,IL2,CBLB,IFNG,IL5,NFATC2,PTGS2,IL2RA,FOS,PRKCQ,FOSL1,TBX21,IL3,EGR4,IL4,EGR3,CALM2,EGR1,SLC3A2,IKZF1,PTPRK,JUNB,CASP3,GATA3,ITCH
myc_represspathway	Validated targets of C-MYC transcriptional repression	0.485133420338572	-0.723331332394337	61	57	0.0277507302823759	2054	2226	7709,4609,1026,4149,2033,8837,10397,3394,7474,1052,9414,223,4800,7249,6278,4801,23671,8841,672,5159,6556,6688,677,1191,2309,3688,3065,1050,5524,3398,6422,1791,4089,3956,6667,6352,1788,2495,2672,10608,596,5933,1278,57447,2064,3655,84233,1647,4802,1030,595,1027,7812,1385,81855,3691,22943	ZBTB17,MYC,CDKN1A,MAX,EP300,CFLAR,NDRG1,IRF8,WNT5A,CEBPD,TJP2,ALDH9A1,NFYA,TSC2,S100A7,NFYB,TMEFF2,HDAC3,BRCA1,PDGFRB,SLC11A1,SPI1,ZFP36L1,CLU,FOXO3,ITGB1,HDAC1,CEBPA,PTPA,ID2,SFRP1,DNTT,SMAD4,LGALS1,SP1,CCL5,DNMT3A,FTH1,GFI1,MXD4,BCL2,RBL1,COL1A2,NDRG2,ERBB2,ITGA6,TMEM126A,GADD45A,NFYC,CDKN2B,CCND1,CDKN1B,CSDE1,CREB1,SFXN3,ITGB4,DKK1
il4_2pathway	IL4-mediated signaling events	0.500219618995939	-0.692708039004837	60	56	0.0272638753651412	2054	2226	3567,5284,3586,10344,2208,4602,54625,3718,207,84666,3716,3159,9021,8660,9046,6356,3565,867,1277,2475,7070,5777,6361,7033,6198,6777,6464,9655,5295,2242,2113,8651,57379,2885,6776,1278,1432,4988,1959,3662,383,3690,4603,6778,5290,6403,1051,246,6688,4049,3717,3667,604,6667,2971,3566	IL5,PIGR,IL10,CCL26,FCER2,MYB,PARP14,JAK3,AKT1,RETNLB,JAK1,HMGA1,SOCS3,IRS2,DOK2,CCL11,IL4,CBL,COL1A1,MTOR,THY1,PTPN6,CCL17,TFF3,RPS6KB1,STAT5B,SHC1,SOCS5,PIK3R1,FES,ETS1,SOCS1,AICDA,GRB2,STAT5A,COL1A2,MAPK14,OPRM1,EGR2,IRF4,ARG1,ITGB3,MYBL1,STAT6,PIK3CA,SELP,CEBPB,ALOX15,SPI1,LTA,JAK2,IRS1,BCL6,SP1,GTF3A,IL4R
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt	0.504249519892402	-0.684684054270427	34	32	0.0155793573515093	2054	2226	1027,2810,6714,10000,5170,208,207,9882,5894,2308,79109,5566,7533,10971,4217,7534,7531,2931,7529,6517,64223,3836,2475,5591,7532,2932,253260,842,3320,1147,2309,1026	CDKN1B,SFN,SRC,AKT3,PDPK1,AKT2,AKT1,TBC1D4,RAF1,FOXO1,MAPKAP1,PRKACA,YWHAH,YWHAQ,MAP3K5,YWHAZ,YWHAE,GSK3A,YWHAB,SLC2A4,MLST8,KPNA1,MTOR,PRKDC,YWHAG,GSK3B,RICTOR,CASP9,HSP90AA1,CHUK,FOXO3,CDKN1A
cxcr3pathway	CXCR3-mediated signaling events	0.504249519892402	-0.684684054270427	34	32	0.0155793573515093	2054	2226	6373,5606,6714,5604,5170,5600,1432,207,3689,1759,5605,5894,5608,79109,5295,3683,5595,2771,2782,2773,54331,2475,64223,5594,5196,5291,253260,6356,3627,10563,5290,408	CXCL11,MAP2K3,SRC,MAP2K1,PDPK1,MAPK11,MAPK14,AKT1,ITGB2,DNM1,MAP2K2,RAF1,MAP2K6,MAPKAP1,PIK3R1,ITGAL,MAPK3,GNAI2,GNB1,GNAI3,GNG2,MTOR,MLST8,MAPK1,PF4,PIK3CB,RICTOR,CCL11,CXCL10,CXCL13,PIK3CA,ARRB1
erbb1_internalization_pathway	Internalization of ErbB1	0.504249519892402	-0.684684054270427	34	32	0.0155793573515093	2054	2226	29924,57732,5894,7251,7321,1759,2885,2060,7323,8867,998,5868,6714,9101,8874,26018,7322,273,6654,867,5291,6456,51652,6453,5290,9146,10617,1950,5295,868,1956,10253	EPN1,ZFYVE28,RAF1,TSG101,UBE2D1,DNM1,GRB2,EPS15,UBE2D3,SYNJ1,CDC42,RAB5A,SRC,USP8,ARHGEF7,LRIG1,UBE2D2,AMPH,SOS1,CBL,PIK3CB,SH3GL2,CHMP3,ITSN1,PIK3CA,HGS,STAMBP,EGF,PIK3R1,CBLB,EGFR,SPRY2
s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway	0.50876566820559	-0.675767745243859	21	20	0.00973709834469328	2054	2226	2768,2781,2769,8879,56848,8698,8877,2767,10672,81537,4363,2773,1901,2770,53637,9294,9630,1903,2776,2771	GNA12,GNAZ,GNA15,SGPL1,SPHK2,S1PR4,SPHK1,GNA11,GNA13,SGPP1,ABCC1,GNAI3,S1PR1,GNAI1,S1PR5,S1PR2,GNA14,S1PR3,GNAQ,GNAI2
p53regulationpathway	p53 pathway	0.515476376977697	-0.662663802030627	59	55	0.0267770204479065	2054	2226	387893,1616,6502,56950,53944,7157,80854,2033,4194,25,2932,1456,91875,1453,63970,5300,10524,7874,10419,5601,11186,7528,207,8493,6135,5580,28996,1455,25898,10848,900,890,1387,1017,1452,6125,8445,1454,5524,8850,4193,9349,472,80204,84148,5515,11200,5599,1434,1877,1432,7321,64326,1111,545	KMT5A,DAXX,SKP2,SMYD2,CSNK1G1,TP53,SETD7,EP300,MDM4,ABL1,GSK3B,CSNK1G3,TTC5,CSNK1D,TP53AIP1,PIN1,KAT5,USP7,PRMT5,MAPK9,RASSF1,YY1,AKT1,PPM1D,RPL11,PRKCD,HIPK2,CSNK1G2,RCHY1,PPP1R13L,CCNG1,CCNA2,CREBBP,CDK2,CSNK1A1,RPL5,DYRK2,CSNK1E,PTPA,KAT2B,MDM2,RPL23,ATM,FBXO11,KAT8,PPP2CA,CHEK2,MAPK8,CSE1L,E4F1,MAPK14,UBE2D1,COP1,CHEK1,ATR
avb3_integrin_pathway	Integrins in angiogenesis	0.519080071142832	-0.655697128057494	46	43	0.0209347614410906	2054	2226	7048,7414,5594,5290,3320,2185,5595,5298,3667,5829,3611,2335,9564,5286,1435,1285,7422,6714,387,1027,10085,6696,3690,867,10451,27329,961,3685,25960,6198,5295,3791,50848,841,207,5879,3480,4240,2247,6382,1436,5297,5781	TGFBR2,VCL,MAPK1,PIK3CA,HSP90AA1,PTK2B,MAPK3,PI4KB,IRS1,PXN,ILK,FN1,BCAR1,PIK3C2A,CSF1,COL4A3,VEGFA,SRC,RHOA,CDKN1B,EDIL3,SPP1,ITGB3,CBL,VAV3,ANGPTL3,CD47,ITGAV,ADGRA2,RPS6KB1,PIK3R1,KDR,F11R,CASP8,AKT1,RAC1,IGF1R,MFGE8,FGF2,SDC1,CSF1R,PI4KA,PTPN11
et_egfrpathway	EGFR-dependent Endothelin signaling events	0.524981149053832	-0.644392923599298	8	8	0.00389483933787731	2054	2226	1909,3265,1950,2885,2475,1956,6654,1906	EDNRA,HRAS,EGF,GRB2,MTOR,EGFR,SOS1,EDN1
ephrina_ephapathway	EphrinA-EPHA pathway	0.524981149053832	-0.644392923599298	8	8	0.00389483933787731	2054	2226	1969,285220,1946,2042,2043,2046,2044,2045	EPHA2,EPHA6,EFNA5,EPHA3,EPHA4,EPHA8,EPHA5,EPHA7
s1p_s1p1_pathway	S1P1 pathway	0.534813229147095	-0.625837697435211	20	19	0.00925024342745862	2054	2226	7422,2771,5595,5330,387,3791,5159,3690,2770,2773,1901,4363,5594,5743,3685,8877,5879,2781,5335	VEGFA,GNAI2,MAPK3,PLCB2,RHOA,KDR,PDGFRB,ITGB3,GNAI1,GNAI3,S1PR1,ABCC1,MAPK1,PTGS2,ITGAV,SPHK1,RAC1,GNAZ,PLCG1
txa2pathway	Thromboxane A2 receptor signaling	0.536535721692187	-0.622622136290669	45	42	0.0204479065238559	2054	2226	2534,5590,6401,7412,4846,157,1956,54331,2782,9138,2771,5566,5739,1950,5581,5879,5729,4067,5578,10681,3383,6850,8766,5580,1759,5583,640,207,409,1432,5600,156,9368,7052,2268,7525,5330,5588,6714,5582,387,3932	FYN,PRKCZ,SELE,VCAM1,NOS3,GRK3,EGFR,GNG2,GNB1,ARHGEF1,GNAI2,PRKACA,PTGIR,EGF,PRKCE,RAC1,PTGDR,LYN,PRKCA,GNB5,ICAM1,SYK,RAB11A,PRKCD,DNM1,PRKCH,BLK,AKT1,ARRB2,MAPK14,MAPK11,GRK2,NHERF1,TGM2,FGR,YES1,PLCB2,PRKCQ,SRC,PRKCG,RHOA,LCK
ar_pathway	Coregulation of Androgen receptor activity	0.546430958139021	-0.604347313950237	57	53	0.0258033106134372	2054	2226	23598,10498,23054,5074,57178,3817,595,2547,51588,10106,3178,27043,7337,8204,5052,23028,7041,2185,6925,10499,23081,58190,6722,2288,26524,2274,896,26060,1499,672,5036,146225,9039,7050,7520,207,8554,4824,841,5469,8031,6840,3092,7329,2934,55818,354,4117,1021,5591,7110,10451,7113	PATZ1,CARM1,NCOA6,PAWR,ZMIZ1,KLK2,CCND1,XRCC6,PIAS4,CTDSP2,HNRNPA1,PELP1,UBE3A,NRIP1,PRDX1,KDM1A,TGFB1I1,PTK2B,TCF4,NCOA2,KDM4C,CTDSP1,SRF,FKBP4,LATS2,FHL2,CCND3,APPL1,CTNNB1,BRCA1,PA2G4,CMTM2,UBA3,TGIF1,XRCC5,AKT1,PIAS1,NKX3-1,CASP8,MED1,NCOA4,SVIL,HIP1,UBE2I,GSN,KDM3A,KLK3,MAK,CDK6,PRKDC,TMF1,VAV3,TMPRSS2
tnfpathway	TNF receptor signaling pathway	0.554187347257451	-0.590252477457241	44	41	0.0199610516066212	2054	2226	7124,330,841,329,8717,6868,8878,8439,4214,5584,5970,8491,8737,6772,23043,857,5606,7295,1540,7128,4215,11183,3551,6609,7132,9530,5590,10399,117584,5609,8567,1147,6885,7133,4217,5871,6610,9448,8772,4790,7185	TNF,BIRC3,CASP8,BIRC2,TRADD,ADAM17,SQSTM1,NSMAF,MAP3K1,PRKCI,RELA,MAP4K3,RIPK1,STAT1,TNIK,CAV1,MAP2K3,TXN,CYLD,TNFAIP3,MAP3K3,MAP4K5,IKBKB,SMPD1,TNFRSF1A,BAG4,PRKCZ,RACK1,RFFL,MAP2K7,MADD,CHUK,MAP3K7,TNFRSF1B,MAP3K5,MAP4K2,SMPD2,MAP4K4,FADD,NFKB1,TRAF1
rb_1pathway	Regulation of retinoblastoma protein	0.562090400727003	-0.576092586638159	56	52	0.0253164556962025	2054	2226	1158,6502,6598,145258,1487,1052,7027,25,2033,7042,1026,8535,5928,4654,5601,5948,860,5600,898,6441,8841,1386,1997,4286,23411,890,7343,1874,1017,4208,1387,5468,3065,1050,5925,1437,3725,5077,4193,1051,6688,11016,4233,6046,1786,1027,6597,5515,26574,5894,1432,632	CKM,SKP2,SMARCB1,GSC,CTBP1,CEBPD,TFDP1,ABL1,EP300,TGFB2,CDKN1A,CBX4,RBBP4,MYOD1,MAPK9,RBP2,RUNX2,MAPK11,CCNE1,SFTPD,HDAC3,ATF2,ELF1,MITF,SIRT1,CCNA2,UBTF,E2F4,CDK2,MEF2C,CREBBP,PPARG,HDAC1,CEBPA,RB1,CSF2,JUN,PAX3,MDM2,CEBPB,SPI1,ATF7,MET,BRD2,DNMT1,CDKN1B,SMARCA4,PPP2CA,AATF,RAF1,MAPK14,BGLAP
wnt_canonical_pathway	Canonical Wnt signaling pathway	0.566208012772001	-0.568793754564133	31	29	0.0141187925998053	2054	2226	4040,8395,5518,8498,857,8452,5515,1499,1855,89780,8454,1856,59349,23291,85409,7855,1857,8312,1452,324,55361,8945,53944,6500,8313,1454,2932,1453,5520	LRP6,PIP5K1B,PPP2R1A,RANBP3,CAV1,CUL3,PPP2CA,CTNNB1,DVL1,WNT3A,CUL1,DVL2,KLHL12,FBXW11,NKD2,FZD5,DVL3,AXIN1,CSNK1A1,APC,PI4K2A,BTRC,CSNK1G1,SKP1,AXIN2,CSNK1E,GSK3B,CSNK1D,PPP2R2A
lis1pathway	Lissencephaly gene (LIS1) in neuronal migration and development	0.566208012772001	-0.568793754564133	31	29	0.0141187925998053	2054	2226	7436,6993,7531,5528,5049,805,8851,7804,8826,1020,25,8941,6249,81565,7941,5649,11104,387,1600,1778,4043,1457,4131,5048,10726,808,998,801,5879	VLDLR,DYNLT1,YWHAE,PPP2R5D,PAFAH1B2,CALM2,CDK5R1,LRP8,IQGAP1,CDK5,ABL1,CDK5R2,CLIP1,NDEL1,PLA2G7,RELN,KATNA1,RHOA,DAB1,DYNC1H1,LRPAP1,CSNK2A1,MAP1B,PAFAH1B1,NUDC,CALM3,CDC42,CALM1,RAC1
rapid_gr_pathway	Rapid glucocorticoid signaling	0.569092901685451	-0.563711586328282	7	7	0.00340798442064265	2054	2226	5600,2782,5601,1392,54331,5599,1432	MAPK11,GNB1,MAPK9,CRH,GNG2,MAPK8,MAPK14
hnf3apathway	FOXA1 transcription factor network	0.572007489512443	-0.558603194134838	43	40	0.0194741966893866	2054	2226	5265,725,2033,1562,3630,3725,5451,1051,2099,338,6667,162,354,729238,7031,1387,653509,8204,4774,4782,7026,23761,522,4824,7356,7494,3169,1826,4731,6469,3171,1027,672,3170,6441,6647,8202,2353,4781,2641	SERPINA1,C4BPB,EP300,CYP2C18,INS,JUN,POU2F1,CEBPB,ESR1,APOB,SP1,AP1B1,KLK3,SFTPA2,TFF1,CREBBP,SFTPA1,NRIP1,NFIA,NFIC,NR2F2,PISD,ATP5PF,NKX3-1,SCGB1A1,XBP1,FOXA1,DSCAM,NDUFV3,SHH,FOXA3,CDKN1B,BRCA1,FOXA2,SFTPD,SOD1,NCOA3,FOS,NFIB,GCG
il2_stat5pathway	IL2 signaling events mediated by STAT5	0.587482121197386	-0.531909465431335	30	28	0.0136319376825706	2054	2226	1997,596,3718,894,6776,9846,2885,3932,356,5781,3559,6654,3716,4049,5551,3565,896,1021,4609,5290,6464,5295,6667,6777,890,3558,3560,598	ELF1,BCL2,JAK3,CCND2,STAT5A,GAB2,GRB2,LCK,FASLG,PTPN11,IL2RA,SOS1,JAK1,LTA,PRF1,IL4,CCND3,CDK6,MYC,PIK3CA,SHC1,PIK3R1,SP1,STAT5B,CCNA2,IL2,IL2RB,BCL2L1
cd40_pathway	CD40/CD40L signaling	0.587482121197386	-0.531909465431335	30	28	0.0136319376825706	2054	2226	5600,9020,958,5599,7128,5601,7187,83953,7189,5970,6416,6776,4214,5602,3718,330,207,329,1432,7185,4790,868,4609,51567,4792,722,3565,3725	MAPK11,MAP3K14,CD40,MAPK8,TNFAIP3,MAPK9,TRAF3,FCAMR,TRAF6,RELA,MAP2K4,STAT5A,MAP3K1,MAPK10,JAK3,BIRC3,AKT1,BIRC2,MAPK14,TRAF1,NFKB1,CBLB,MYC,TDP2,NFKBIA,C4BPA,IL4,JUN
arf_3pathway	Arf1 pathway	0.589144573376662	-0.529083669801876	18	17	0.00827653359298929	2054	2226	920,1173,375,160,23163,1212,9266,1211,5338,8394,9570,55738,50807,8729,23647,5879,8615	CD4,AP2M1,ARF1,AP2A1,GGA3,CLTB,CYTH2,CLTA,PLD2,PIP5K1A,GOSR2,ARFGAP1,ASAP1,GBF1,ARFIP2,RAC1,USO1
ar_nongenomic_pathway	Nongenotropic Androgen signaling	0.589144573376662	-0.529083669801876	18	17	0.00827653359298929	2054	2226	2796,5894,207,5594,3265,5605,27043,6462,5290,5604,6714,2782,5595,1385,5295,2353,54331	GNRH1,RAF1,AKT1,MAPK1,HRAS,MAP2K2,PELP1,SHBG,PIK3CA,MAP2K1,SRC,GNB1,MAPK3,CREB1,PIK3R1,FOS,GNG2
pi3kcipathway	Class I PI3K signaling events	0.608032325047108	-0.49752723223334	41	38	0.0185004868549172	2054	2226	59339,640,9266,5335,4067,5879,381,3932,8874,387,7525,57580,9265,375,6714,5170,6654,2268,27071,5336,6446,11033,382,5291,5728,3636,3702,3320,2309,5290,2534,59338,5295,5906,7409,7074,9267,64411	PLEKHA2,BLK,CYTH2,PLCG1,LYN,RAC1,ARF5,LCK,ARHGEF7,RHOA,YES1,PREX1,CYTH3,ARF1,SRC,PDPK1,SOS1,FGR,DAPP1,PLCG2,SGK1,ADAP1,ARF6,PIK3CB,PTEN,INPPL1,ITK,HSP90AA1,FOXO3,PIK3CA,FYN,PLEKHA1,PIK3R1,RAP1A,VAV1,TIAM1,CYTH1,ARAP3
bard1pathway	BARD1 signaling events	0.608993424906162	-0.495947807872128	29	27	0.0131450827653359	2054	2226	7332,2188,2130,10111,2176,580,5591,55120,4869,4361,2175,4683,5888,7157,1017,2178,2189,7323,545,5111,7520,2547,472,11073,672,2177,898	UBE2L3,FANCF,EWSR1,RAD50,FANCC,BARD1,PRKDC,FANCL,NPM1,MRE11,FANCA,NBN,RAD51,TP53,CDK2,FANCE,FANCG,UBE2D3,ATR,PCNA,XRCC5,XRCC6,ATM,TOPBP1,BRCA1,FANCD2,CCNE1
nfkappabalternativepathway	Alternative NF-kappaB pathway	0.616887813349493	-0.48306809762289	6	6	0.00292112950340798	2054	2226	8945,4790,1147,9020,5971,4791	BTRC,NFKB1,CHUK,MAP3K14,RELB,NFKB2
syndecan_1_pathway	Syndecan-1-mediated signaling events	0.617303747707875	-0.482394078471809	17	16	0.00778967867575463	2054	2226	5594,5479,6386,682,4316,6352,7040,5566,4318,5595,4233,3082,4312,6382,3911,10855	MAPK1,PPIB,SDCBP,BSG,MMP7,CCL5,TGFB1,PRKACA,MMP9,MAPK3,MET,HGF,MMP1,SDC1,LAMA5,HPSE
igf1_pathway	IGF1 pathway	0.630690170890772	-0.460940549878601	28	26	0.0126582278481013	2054	2226	6198,1398,6464,5295,5587,8440,3667,5829,7534,7531,2887,3265,5290,5590,10399,8660,5170,6654,5781,5894,5580,9564,207,5770,2885,3480	RPS6KB1,CRK,SHC1,PIK3R1,PRKD1,NCK2,IRS1,PXN,YWHAZ,YWHAE,GRB10,HRAS,PIK3CA,PRKCZ,RACK1,IRS2,PDPK1,SOS1,PTPN11,RAF1,PRKCD,BCAR1,AKT1,PTPN1,GRB2,IGF1R
hdac_classiii_pathway	Signaling events mediated by HDAC Class III	0.644345955664074	-0.439519498880961	39	36	0.0175267770204479	2054	2226	10376,2309,1026,8850,8367,51547,3206,55902,7280,2274,2033,7157,8370,3008,8359,1387,121504,9759,2308,8362,23411,8368,84532,581,8365,8363,10891,4209,22933,8360,2547,23410,4654,8364,8366,8361	TUBA1B,FOXO3,CDKN1A,KAT2B,H4C5,SIRT7,HOXA10,ACSS2,TUBB2A,FHL2,EP300,TP53,H4C14,H1-4,H4C1,CREBBP,H4C16,HDAC4,FOXO1,H4C12,SIRT1,H4C13,ACSS1,BAX,H4C8,H4C11,PPARGC1A,MEF2D,SIRT2,H4C4,XRCC6,SIRT3,MYOD1,H4C3,H4C2,H4C6
ephrinbrevpathway	Ephrin B reverse signaling	0.652515236713761	-0.426920788772469	27	25	0.0121713729308666	2054	2226	1759,640,3674,6416,4067,5879,5998,5290,2534,5295,3932,2048,6885,7525,7074,5783,6714,2047,5599,2268,7852,1948,2050,8440,3690	DNM1,BLK,ITGA2B,MAP2K4,LYN,RAC1,RGS3,PIK3CA,FYN,PIK3R1,LCK,EPHB2,MAP3K7,YES1,TIAM1,PTPN13,SRC,EPHB1,MAPK8,FGR,CXCR4,EFNB2,EPHB4,NCK2,ITGB3
ar_tf_pathway	Regulation of Androgen receptor activity	0.657200068804835	-0.419766788125123	50	46	0.0223953261927945	2054	2226	1432,11143,6605,3817,6714,8648,6599,2908,5585,5599,10498,5966,3725,1050,3065,3320,10481,8850,5451,10499,4193,25898,25803,6595,51564,1387,6416,23411,5608,2308,83637,1958,3301,2033,2624,2932,7113,7181,29843,10399,10513,10524,10919,8805,5152,354	MAPK14,KAT7,SMARCE1,KLK2,SRC,NCOA1,SMARCC1,NR3C1,PKN1,MAPK8,CARM1,REL,JUN,CEBPA,HDAC1,HSP90AA1,HOXB13,KAT2B,POU2F1,NCOA2,MDM2,RCHY1,SPDEF,SMARCA2,HDAC7,CREBBP,MAP2K4,SIRT1,MAP2K6,FOXO1,ZMIZ2,EGR1,DNAJA1,EP300,GATA2,GSK3B,TMPRSS2,NR2C1,SENP1,RACK1,APPBP2,KAT5,EHMT2,TRIM24,PDE9A,KLK3
plk3_pathway	PLK3 signaling events	0.668671465812217	-0.402462421967357	5	5	0.00243427458617332	2054	2226	898,7157,1263,995,11200	CCNE1,TP53,PLK3,CDC25C,CHEK2
nephrin_neph1_pathway	Nephrin/Neph1 signaling in the kidney podocyte	0.674406004704973	-0.393922968560446	26	24	0.0116845180136319	2054	2226	7225,2151,5601,7827,4690,5599,409,207,23607,4868,5602,6416,5335,2885,5879,5295,7082,8440,3725,8976,5291,55243,2534,5290	TRPC6,F2RL2,MAPK9,NPHS2,NCK1,MAPK8,ARRB2,AKT1,CD2AP,NPHS1,MAPK10,MAP2K4,PLCG1,GRB2,RAC1,PIK3R1,TJP1,NCK2,JUN,WASL,PIK3CB,KIRREL1,FYN,PIK3CA
hif1apathway	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.675177175254271	-0.392780140693764	15	14	0.0068159688412853	2054	2226	6921,7157,10956,10987,55662,6923,7428,9978,3320,10399,405,3091,8453,64344	ELOC,TP53,OS9,COPS5,HIF1AN,ELOB,VHL,RBX1,HSP90AA1,RACK1,ARNT,HIF1A,CUL2,HIF3A
lpa4_pathway	LPA4-mediated signaling events	0.675177175254271	-0.392780140693764	15	14	0.0068159688412853	2054	2226	5566,113,2774,1385,114,107,196883,108,111,112,9252,5581,115,109	PRKACA,ADCY7,GNAL,CREB1,ADCY8,ADCY1,ADCY4,ADCY2,ADCY5,ADCY6,RPS6KA5,PRKCE,ADCY9,ADCY3
e2f_pathway	E2F transcription factor network	0.680384884755446	-0.385096633940222	72	66	0.0321324245374878	2054	2226	26959,23429,1870,7029,1871,1876,7027,990,2033,1719,983,5928,1026,4609,283848,5902,11073,8295,10419,7528,4170,993,672,898,4605,5934,23411,23491,890,221223,317,6667,1017,6595,1387,5328,1874,7515,1066,1869,5054,896,7083,1050,3065,5925,8824,840,1875,8936,3090,4998,8850,9134,6822,472,6241,1027,7161,1031,6240,7298,23468,144455,5933,4172	HBP1,RYBP,E2F2,TFDP2,E2F3,E2F6,TFDP1,CDC6,EP300,DHFR,CDK1,RBBP4,CDKN1A,MYC,CES4A,RANBP1,TOPBP1,TRRAP,PRMT5,YY1,MCL1,CDC25A,BRCA1,CCNE1,MYBL2,RBL2,SIRT1,CES3,CCNA2,CES5A,APAF1,SP1,CDK2,SMARCA2,CREBBP,PLAU,E2F4,XRCC1,CES1,E2F1,SERPINE1,CCND3,TK1,CEBPA,HDAC1,RB1,CES2,CASP7,E2F5,WASF1,HIC1,ORC1,KAT2B,CCNE2,SULT2A1,ATM,RRM2,CDKN1B,TP73,CDKN2C,RRM1,TYMS,CBX5,E2F7,RBL1,MCM3
foxm1pathway	FOXM1 transcription factor network	0.680649219559154	-0.384708201635413	37	34	0.0165530671859786	2054	2226	2119,7039,332,3175,4313,994,891,675,2353,11200,5604,3910,1059,4775,595,4609,2099,983,5925,9212,5347,9133,2033,7515,1019,2931,1387,1017,6667,2619,1058,6502,1063,4751	ETV5,TGFA,BIRC5,ONECUT1,MMP2,CDC25B,CCNB1,BRCA2,FOS,CHEK2,MAP2K1,LAMA4,CENPB,NFATC3,CCND1,MYC,ESR1,CDK1,RB1,AURKB,PLK1,CCNB2,EP300,XRCC1,CDK4,GSK3A,CREBBP,CDK2,SP1,GAS1,CENPA,SKP2,CENPF,NEK2
il23pathway	IL23-mediated signaling events	0.680649219559154	-0.384708201635413	37	34	0.0165530671859786	2054	2226	2919,3606,9021,6772,8807,6775,112744,8809,29949,7124,3605,3569,6776,6774,5970,3458,3675,5295,920,3558,4790,7297,242,11009,3717,149233,916,3594,6347,4792,3593,4353,5290,3553	CXCL1,IL18,SOCS3,STAT1,IL18RAP,STAT4,IL17F,IL18R1,IL19,TNF,IL17A,IL6,STAT5A,STAT3,RELA,IFNG,ITGA3,PIK3R1,CD4,IL2,NFKB1,TYK2,ALOX12B,IL24,JAK2,IL23R,CD3E,IL12RB1,CCL2,NFKBIA,IL12B,MPO,PIK3CA,IL1B
angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling	0.688737165947684	-0.372895552521389	48	44	0.0214216163583252	2054	2226	285,5340,2247,51378,2147,4690,5599,5781,4313,7124,1432,2888,1997,207,5338,6776,5879,2308,5970,2885,1398,6464,5921,5295,2242,2113,5595,6198,6777,5829,2335,4846,4790,5058,3688,7010,5594,1998,185,9046,5290,1026,284,2534	ANGPT2,PLG,FGF2,ANGPT4,F2,NCK1,MAPK8,PTPN11,MMP2,TNF,MAPK14,GRB14,ELF1,AKT1,PLD2,STAT5A,RAC1,FOXO1,RELA,GRB2,CRK,SHC1,RASA1,PIK3R1,FES,ETS1,MAPK3,RPS6KB1,STAT5B,PXN,FN1,NOS3,NFKB1,PAK1,ITGB1,TEK,MAPK1,ELF2,AGTR1,DOK2,PIK3CA,CDKN1A,ANGPT1,FYN
amb2_neutrophils_pathway	amb2 Integrin signaling	0.688737165947684	-0.372895552521389	48	44	0.0214216163583252	2054	2226	3827,2335,4790,5328,1991,338,1490,4353,6403,58494,387,3240,5340,6714,7525,640,7124,3383,4486,3684,7070,5590,177,2534,3491,6404,2811,2268,5327,4620,5329,3146,3932,4485,4018,4318,3569,4067,3384,4035,207,83700,3689,4313	KNG1,FN1,NFKB1,PLAU,ELANE,APOB,CCN2,MPO,SELP,JAM2,RHOA,HP,PLG,SRC,YES1,BLK,TNF,ICAM1,MST1R,ITGAM,THY1,PRKCZ,AGER,FYN,CCN1,SELPLG,GP1BA,FGR,PLAT,MYH2,PLAUR,HMGB1,LCK,MST1,LPA,MMP9,IL6,LYN,ICAM2,LRP1,AKT1,JAM3,ITGB2,MMP2
nectin_pathway	Nectin adhesion pathway	0.696294285392281	-0.361982884173044	25	23	0.0111976630963973	2054	2226	1495,5295,1398,5818,25945,50848,999,8826,9076,2889,3685,5290,7410,6714,5817,23396,5819,3690,5159,1499,5879,5797,998	CTNNA1,PIK3R1,CRK,NECTIN1,NECTIN3,F11R,CDH1,IQGAP1,CLDN1,RAPGEF1,ITGAV,PIK3CA,VAV2,SRC,PVR,PIP5K1C,NECTIN2,ITGB3,PDGFRB,CTNNB1,RAC1,PTPRM,CDC42
trail_pathway	TRAIL signaling pathway	0.696294285392281	-0.361982884173044	25	23	0.0111976630963973	2054	2226	8772,5595,5295,1147,8797,5290,8743,5291,5594,6609,8837,3551,8793,5599,7818,843,8737,8794,4214,6416,8795,8717,841	FADD,MAPK3,PIK3R1,CHUK,TNFRSF10A,PIK3CA,TNFSF10,PIK3CB,MAPK1,SMPD1,CFLAR,IKBKB,TNFRSF10D,MAPK8,DAP3,CASP10,RIPK1,TNFRSF10C,MAP3K1,MAP2K4,TNFRSF10B,TRADD,CASP8
rxr_vdr_pathway	RXR and RAR heterodimerization with other nuclear receptor	0.70466110481675	-0.350038294131889	14	13	0.00632911392405063	2054	2226	19,7421,6256,7124,596,5469,3164,9612,7040,8648,6258,9971,6198	ABCA1,VDR,RXRA,TNF,BCL2,MED1,NR4A1,NCOR2,TGFB1,NCOA1,RXRG,NR1H4,RPS6KB1
s1p_s1p4_pathway	S1P4 pathway	0.70466110481675	-0.350038294131889	14	13	0.00632911392405063	2054	2226	10672,8698,998,5335,2781,2768,5594,2770,2773,2771,5595,53637,387	GNA13,S1PR4,CDC42,PLCG1,GNAZ,GNA12,MAPK1,GNAI1,GNAI3,GNAI2,MAPK3,S1PR5,RHOA
notch_pathway	Notch signaling pathway	0.711203814884615	-0.34079623078584	58	53	0.0258033106134372	2054	2226	182,92737,6500,83464,54567,3065,27255,2011,23028,8945,1840,9148,171558,84708,55294,1759,4854,8766,2023,3714,9612,595,4855,23013,4609,1026,2033,8038,4237,867,3565,10683,8788,8650,83737,2625,1487,8076,6502,8454,3516,9611,102,5045,4853,2060,51107,1272,9794,7528,23385,26292,84441	JAG1,DNER,SKP1,APH1B,DLL4,HDAC1,CNTN6,MARK2,KDM1A,BTRC,DTX1,NEURL1,PTCRA,LNX1,FBXW7,DNM1,NOTCH3,RAB11A,ENO1,JAG2,NCOR2,CCND1,NOTCH4,SPEN,MYC,CDKN1A,EP300,ADAM12,MFAP2,CBL,IL4,DLL3,DLK1,NUMB,ITCH,GATA3,CTBP1,MFAP5,SKP2,CUL1,RBPJ,NCOR1,ADAM10,FURIN,NOTCH2,EPS15,APH1A,CNTN1,MAML1,YY1,NCSTN,MYCBP,MAML2
il1pathway	IL1-mediated signaling events	0.716610258108869	-0.333223159241834	35	32	0.0155793573515093	2054	2226	23085,3554,3551,387522,3725,54472,3553,7850,5290,1147,7335,11213,4615,51135,5590,5295,6885,3552,4790,7334,5608,5584,5970,8878,23118,7189,353376,834,4215,3557,10454,5599	ERC1,IL1R1,IKBKB,PEDS1-UBE2V1,JUN,TOLLIP,IL1B,IL1R2,PIK3CA,CHUK,UBE2V1,IRAK3,MYD88,IRAK4,PRKCZ,PIK3R1,MAP3K7,IL1A,NFKB1,UBE2N,MAP2K6,PRKCI,RELA,SQSTM1,TAB2,TRAF6,TICAM2,CASP1,MAP3K3,IL1RN,TAB1,MAPK8
faspathway	FAS (CD95) signaling pathway	0.716610258108869	-0.333223159241834	35	32	0.0155793573515093	2054	2226	5981,5599,5170,23017,5600,8737,356,843,6714,5601,4214,5602,5608,1213,841,330,355,329,207,1432,6850,7430,8772,5295,836,5609,5290,1147,8837,3551,6609,5291	RFC1,MAPK8,PDPK1,FAIM2,MAPK11,RIPK1,FASLG,CASP10,SRC,MAPK9,MAP3K1,MAPK10,MAP2K6,CLTC,CASP8,BIRC3,FAS,BIRC2,AKT1,MAPK14,SYK,EZR,FADD,PIK3R1,CASP3,MAP2K7,PIK3CA,CHUK,CFLAR,IKBKB,SMPD1,PIK3CB
s1p_s1p2_pathway	S1P2 pathway	0.718106301791847	-0.331137668257738	24	22	0.0107108081791626	2054	2226	2767,2781,2769,1003,3725,5594,2770,5058,3667,2773,5595,2776,2771,10672,5879,2768,1432,5599,2353,9630,9294,387	GNA11,GNAZ,GNA15,CDH5,JUN,MAPK1,GNAI1,PAK1,IRS1,GNAI3,MAPK3,GNAQ,GNAI2,GNA13,RAC1,GNA12,MAPK14,MAPK8,FOS,GNA14,S1PR2,RHOA
alk1pathway	ALK1 signaling events	0.718106301791847	-0.331137668257738	24	22	0.0107108081791626	2054	2226	3624,2280,5499,7043,857,7040,4089,5595,2658,7046,4092,5594,409,92,90,7048,3196,4090,659,4086,94,4093	INHBA,FKBP1A,PPP1CA,TGFB3,CAV1,TGFB1,SMAD4,MAPK3,GDF2,TGFBR1,SMAD7,MAPK1,ARRB2,ACVR2A,ACVR1,TGFBR2,TLX2,SMAD5,BMPR2,SMAD1,ACVRL1,SMAD9
ps1pathway	Presenilin action in Notch and Wnt signaling	0.71982005247357	-0.328754025329065	46	42	0.0204479065238559	2054	2226	6927,5467,8321,51107,23291,102,3516,5663,4734,22943,4040,595,1855,23385,10454,2353,1457,1499,3065,2932,79412,83464,5594,3725,4609,166,8312,27123,5595,11197,10023,1487,6885,7088,85407,5528,7471,8945,1840,324,1452,1387	HNF1A,PPARD,FZD1,APH1A,FBXW11,ADAM10,RBPJ,PSEN1,NEDD4,DKK1,LRP6,CCND1,DVL1,NCSTN,TAB1,FOS,CSNK2A1,CTNNB1,HDAC1,GSK3B,KREMEN2,APH1B,MAPK1,JUN,MYC,TLE5,AXIN1,DKK2,MAPK3,WIF1,FRAT1,CTBP1,MAP3K7,TLE1,NKD1,PPP2R5D,WNT1,BTRC,DTX1,APC,CSNK1A1,CREBBP
plk_pathway	Polo-like kinase signaling events in the cell cycle	0.724774632701015	-0.321894523898663	4	4	0.00194741966893866	2054	2226	5347,1263,10769,10733	PLK1,PLK3,PLK2,PLK4
syndecan_pathway	Proteogylcan syndecan-mediated signaling events	0.724774632701015	-0.321894523898663	4	4	0.00194741966893866	2054	2226	9672,6382,6383,6385	SDC3,SDC1,SDC2,SDC4
tcrjnkpathway	JNK signaling in the CD4+ TCR pathway	0.73431829939281	-0.308812693967858	13	12	0.00584225900681597	2054	2226	3937,1398,6885,5599,28988,9402,3725,11184,6416,4214,5579,1326	LCP2,CRK,MAP3K7,MAPK8,DBNL,GRAP2,JUN,MAP4K1,MAP2K4,MAP3K1,PRKCB,MAP3K8
hdac_classii_pathway	Signaling events mediated by HDAC Class II	0.734350725117799	-0.308768537354689	34	31	0.0150925024342746	2054	2226	79885,83933,57763,814,156,8841,2908,9612,10376,2099,7514,3320,7280,5905,2624,8625,6722,7341,5903,4208,7529,54331,51564,9734,7531,9759,7329,2782,604,10014,5901	HDAC11,HDAC10,ANKRA2,CAMK4,GRK2,HDAC3,NR3C1,NCOR2,TUBA1B,ESR1,XPO1,HSP90AA1,TUBB2A,RANGAP1,GATA2,RFXANK,SRF,SUMO1,RANBP2,MEF2C,YWHAB,GNG2,HDAC7,HDAC9,YWHAE,HDAC4,UBE2I,GNB1,BCL6,HDAC5,RAN
hif2pathway	HIF-2-alpha transcription factor network	0.734350725117799	-0.308768537354689	34	31	0.0150925024342746	2054	2226	3791,6923,2113,5460,54583,6667,55662,1387,6921,2033,5054,9429,4323,2034,3646,7428,2321,10370,2056,7422,112399,1942,7291,4891,2395,405,112398,23411,135,6513,8553	KDR,ELOB,ETS1,POU5F1,EGLN1,SP1,HIF1AN,CREBBP,ELOC,EP300,SERPINE1,ABCG2,MMP14,EPAS1,EIF3E,VHL,FLT1,CITED2,EPO,VEGFA,EGLN3,EFNA1,TWIST1,SLC11A2,FXN,ARNT,EGLN2,SIRT1,ADORA2A,SLC2A1,BHLHE40
lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium	0.739762747985701	-0.301425755020695	23	21	0.0102239532619279	2054	2226	5600,6195,6654,3672,2335,5595,2324,1398,5295,1385,5290,2885,6416,3673,7424,1278,3688,1277,1432,207,5594	MAPK11,RPS6KA1,SOS1,ITGA1,FN1,MAPK3,FLT4,CRK,PIK3R1,CREB1,PIK3CA,GRB2,MAP2K4,ITGA2,VEGFC,COL1A2,ITGB1,COL1A1,MAPK14,AKT1,MAPK1
cone_pathway	Visual signal transduction: Cones	0.739762747985701	-0.301425755020695	23	21	0.0102239532619279	2054	2226	8787,5149,6011,2780,9626,25769,10681,54714,131890,6121,3000,2784,5959,2793,2979,2978,388531,9227,1261,5146,145226	RGS9,PDE6H,GRK1,GNAT2,GUCA1C,SLC24A2,GNB5,CNGB3,GRK7,RPE65,GUCY2D,GNB3,RDH5,GNGT2,GUCA1B,GUCA1A,RGS9BP,LRAT,CNGA3,PDE6C,RDH12
prlsignalingeventspathway	Signaling events mediated by PRL	0.739762747985701	-0.301425755020695	23	21	0.0102239532619279	2054	2226	5876,11156,6714,22809,890,5595,183,387,898,8073,3672,1017,9564,5594,1958,389,3688,1026,10376,5879,7803	RABGGTB,PTP4A3,SRC,ATF5,CCNA2,MAPK3,AGT,RHOA,CCNE1,PTP4A2,ITGA1,CDK2,BCAR1,MAPK1,EGR1,RHOC,ITGB1,CDKN1A,TUBA1B,RAC1,PTP4A1
plk1_pathway	PLK1 signaling events	0.750208912081455	-0.287403561797534	44	40	0.0194741966893866	2054	2226	147841,10726,3619,1894,23291,7465,10112,991,701,8555,5518,387,79682,5861,55857,994,891,51343,699,5515,10403,63967,5347,1062,995,22981,64689,4659,5500,983,22974,3796,2801,6790,9475,5058,8945,151648,26271,79866	SPC24,NUDC,INCENP,ECT2,FBXW11,WEE1,KIF20A,CDC20,BUB1B,CDC14B,PPP2R1A,RHOA,CENPU,RAB1A,KIZ,CDC25B,CCNB1,FZR1,BUB1,PPP2CA,NDC80,CLSPN,PLK1,CENPE,CDC25C,NINL,GORASP1,PPP1R12A,PPP1CB,CDK1,TPX2,KIF2A,GOLGA2,AURKA,ROCK2,PAK1,BTRC,SGO1,FBXO5,BORA
epopathway	EPO signaling pathway	0.75186845666371	-0.28519389498272	33	30	0.0146056475170399	2054	2226	596,1432,5335,6776,4067,2885,7225,2549,6772,2056,9021,5599,6654,5781,5336,3717,3265,2889,867,8660,10019,2057,7410,5295,6464,5906,6777,5777,598,4790	BCL2,MAPK14,PLCG1,STAT5A,LYN,GRB2,TRPC6,GAB1,STAT1,EPO,SOCS3,MAPK8,SOS1,PTPN11,PLCG2,JAK2,HRAS,RAPGEF1,CBL,IRS2,SH2B3,EPOR,VAV2,PIK3R1,SHC1,RAP1A,STAT5B,PTPN6,BCL2L1,NFKB1
syndecan_2_pathway	Syndecan-2-mediated signaling events	0.75186845666371	-0.28519389498272	33	30	0.0146056475170399	2054	2226	7430,2335,3827,2035,23495,5921,2048,836,5595,284217,5566,7040,10399,3673,4763,3688,1437,3265,5594,5599,387,3576,6714,858,581,6383,3909,4313,6386,5580	EZR,FN1,KNG1,EPB41,TNFRSF13B,RASA1,EPHB2,CASP3,MAPK3,LAMA1,PRKACA,TGFB1,RACK1,ITGA2,NF1,ITGB1,CSF2,HRAS,MAPK1,MAPK8,RHOA,CXCL8,SRC,CAV2,BAX,SDC2,LAMA3,MMP2,SDCBP,PRKCD
ephbfwdpathway	EPHB forward signaling	0.75186845666371	-0.28519389498272	33	30	0.0146056475170399	2054	2226	1946,1759,2885,5879,998,8867,6714,2047,5604,2049,1948,2050,4690,3265,5594,8976,6453,5290,8997,6237,5595,2048,5921,5295,7018,5058,1949,2890,9448,5829	EFNA5,DNM1,GRB2,RAC1,CDC42,SYNJ1,SRC,EPHB1,MAP2K1,EPHB3,EFNB2,EPHB4,NCK1,HRAS,MAPK1,WASL,ITSN1,PIK3CA,KALRN,RRAS,MAPK3,EPHB2,RASA1,PIK3R1,TF,PAK1,EFNB3,GRIA1,MAP4K4,PXN
hdac_classi_pathway	Signaling events mediated by HDAC Class I	0.755321560049923	-0.280611713055012	66	60	0.0292112950340798	2054	2226	8850,7514,23409,5468,3065,7341,4092,8945,4790,5903,51564,9734,9759,1387,8819,5566,10014,5901,5970,4084,9219,7124,25942,57459,23410,23408,23381,1107,79084,57154,9612,54815,51547,10284,7181,4792,5928,5905,7132,2624,2033,4149,23309,7329,1108,8932,3066,79885,9611,6774,23411,83933,7024,53615,7528,8841,22933,10419,51548,161882	KAT2B,XPO1,SIRT4,PPARG,HDAC1,SUMO1,SMAD7,BTRC,NFKB1,RANBP2,HDAC7,HDAC9,HDAC4,CREBBP,SAP30,PRKACA,HDAC5,RAN,RELA,MXD1,MTA2,TNF,SIN3A,GATAD2B,SIRT3,SIRT5,SMG5,CHD3,WDR77,SMURF1,NCOR2,GATAD2A,SIRT7,SAP18,NR2C1,NFKBIA,RBBP4,RANGAP1,TNFRSF1A,GATA2,EP300,MAX,SIN3B,UBE2I,CHD4,MBD2,HDAC2,HDAC11,NCOR1,STAT3,SIRT1,HDAC10,TFCP2,MBD3,YY1,HDAC3,SIRT2,PRMT5,SIRT6,ZFPM1
pdgfrapathway	PDGFR-alpha signaling pathway	0.761178937332838	-0.272886814288694	22	20	0.00973709834469328	2054	2226	3725,2889,6722,90525,859,5156,5335,2885,3685,5290,3458,6461,5295,6464,1398,857,1457,2353,6654,3716	JUN,RAPGEF1,SRF,SHF,CAV3,PDGFRA,PLCG1,GRB2,ITGAV,PIK3CA,IFNG,SHB,PIK3R1,SHC1,CRK,CAV1,CSNK2A1,FOS,SOS1,JAK1
il6_7pathway	IL6-mediated signaling events	0.765066400411945	-0.267792650998211	43	39	0.0189873417721519	2054	2226	3570,5600,3716,6654,4170,2353,5781,6772,9021,5608,5879,3929,2308,2885,6416,6774,4286,3572,3569,5580,2266,8554,207,1432,7297,8600,3726,5295,8543,7409,1052,5290,4609,1051,3659,1401,2,3717,3725	IL6R,MAPK11,JAK1,SOS1,MCL1,FOS,PTPN11,STAT1,SOCS3,MAP2K6,RAC1,LBP,FOXO1,GRB2,MAP2K4,STAT3,MITF,IL6ST,IL6,PRKCD,FGG,PIAS1,AKT1,MAPK14,TYK2,TNFSF11,JUNB,PIK3R1,LMO4,VAV1,CEBPD,PIK3CA,MYC,CEBPB,IRF1,CRP,A2M,JAK2,JUN
fak_pathway	Signaling events mediated by focal adhesion kinase	0.765097975492237	-0.267751380817317	54	49	0.0238558909444985	2054	2226	5894,9564,50807,2885,5335,7525,5604,6714,595,387,11099,5599,3693,6654,824,673,23092,7414,8976,3688,5594,3725,2889,5290,6237,9826,23162,1793,9475,5829,64283,5879,9815,9844,6416,5601,8874,87,3685,2534,4323,6455,5295,5921,1398,2113,58,5058,2909	RAF1,BCAR1,ASAP1,GRB2,PLCG1,YES1,MAP2K1,SRC,CCND1,RHOA,PTPN21,MAPK8,ITGB5,SOS1,CAPN2,BRAF,ARHGAP26,VCL,WASL,ITGB1,MAPK1,JUN,RAPGEF1,PIK3CA,RRAS,ARHGEF11,MAPK8IP3,DOCK1,ROCK2,PXN,ARHGEF28,RAC1,GIT2,ELMO1,MAP2K4,MAPK9,ARHGEF7,ACTN1,ITGAV,FYN,MMP14,SH3GL1,PIK3R1,RASA1,CRK,ETS1,ACTA1,PAK1,ARHGAP35
alphasynuclein_pathway	Alpha-synuclein signaling	0.76911486981088	-0.262514945065099	32	29	0.0141187925998053	2054	2226	2280,5595,11315,5528,5337,5594,7332,7345,2185,2534,10273,6531,3932,5071,7525,5330,6714,2869,1457,1861,5653,2268,7054,640,5338,6850,6622,5580,4067	FKBP1A,MAPK3,PARK7,PPP2R5D,PLD1,MAPK1,UBE2L3,UCHL1,PTK2B,FYN,STUB1,SLC6A3,LCK,PRKN,YES1,PLCB2,SRC,GRK5,CSNK2A1,TOR1A,KLK6,FGR,TH,BLK,PLD2,SYK,SNCA,PRKCD,LYN
alk1_2pathway	ALK1 pathway	0.785555342998043	-0.241364368010181	3	3	0.00146056475170399	2054	2226	2280,94,90	FKBP1A,ACVRL1,ACVR1
pi3kcibpathway	Class IB PI3K non-lipid kinase events	0.785555342998043	-0.241364368010181	3	3	0.00146056475170399	2054	2226	5140,5594,5604	PDE3B,MAPK1,MAP2K1
aurora_kinase_pathway	Signaling by Aurora kinases	0.785555342998043	-0.241364368010181	3	3	0.00146056475170399	2054	2226	6795,9212,6790	AURKC,AURKB,AURKA
hnf3pathway	FOXA transcription factor networks	0.785555342998043	-0.241364368010181	3	3	0.00146056475170399	2054	2226	3170,3171,3169	FOXA2,FOXA3,FOXA1
ephrinarevpathway	Ephrin A  reverse signaling	0.785555342998043	-0.241364368010181	3	3	0.00146056475170399	2054	2226	2044,1946,2534	EPHA5,EFNA5,FYN
aurora_c_pathway	Aurora C signaling	0.785555342998043	-0.241364368010181	3	3	0.00146056475170399	2054	2226	3619,6795,9212	INCENP,AURKC,AURKB
a4b1_a4b7_pathway	a4b1 and a4b7 Integrin signaling	0.785555342998043	-0.241364368010181	3	3	0.00146056475170399	2054	2226	3676,3688,3695	ITGA4,ITGB1,ITGB7
tcrraspathway	Ras signaling in the CD4+ TCR pathway	0.793415626221167	-0.231408075833483	11	10	0.00486854917234664	2054	2226	5778,1326,5578,5579,2353,5595,5894,673,5604,5594	PTPN7,MAP3K8,PRKCA,PRKCB,FOS,MAPK3,RAF1,BRAF,MAP2K1,MAPK1
rhoa_pathway	RhoA signaling pathway	0.793953116253777	-0.2307308670177	41	37	0.0180136319376826	2054	2226	57591,5728,5590,4659,3491,3725,6550,6300,7414,6456,6722,4633,7430,9475,5962,58,998,3985,6416,5608,6548,5586,1729,1386,8394,5338,1072,2353,5585,5599,3984,387,1027,8395,23396,2151,5606	MRTFA,PTEN,PRKCZ,PPP1R12A,CCN1,JUN,SLC9A3,MAPK12,VCL,SH3GL2,SRF,MYL2,EZR,ROCK2,RDX,ACTA1,CDC42,LIMK2,MAP2K4,MAP2K6,SLC9A1,PKN2,DIAPH1,ATF2,PIP5K1A,PLD2,CFL1,FOS,PKN1,MAPK8,LIMK1,RHOA,CDKN1B,PIP5K1B,PIP5K1C,F2RL2,MAP2K3
wnt_noncanonical_pathway	Noncanonical Wnt signaling pathway	0.802595158311858	-0.219904853672054	30	27	0.0131450827653359	2054	2226	55636,7474,1452,2535,4920,1857,6885,5590,5468,815,1855,10454,5599,9869,7525,5601,23002,387,5879,5602,998,115908,1856,23118,4773,409,8324	CHD7,WNT5A,CSNK1A1,FZD2,ROR2,DVL3,MAP3K7,PRKCZ,PPARG,CAMK2A,DVL1,TAB1,MAPK8,SETDB1,YES1,MAPK9,DAAM1,RHOA,RAC1,MAPK10,CDC42,CTHRC1,DVL2,TAB2,NFATC2,ARRB2,FZD7
a4b1_paxdep_pathway	Paxillin-dependent events mediated by a4b1	0.823064671012039	-0.194720501790777	19	17	0.00827653359298929	2054	2226	5879,5290,28964,382,3676,9564,867,3695,3689,3688,7412,5829,3683,5566,1793,1398,5295	RAC1,PIK3CA,GIT1,ARF6,ITGA4,BCAR1,CBL,ITGB7,ITGB2,ITGB1,VCAM1,PXN,ITGAL,PRKACA,DOCK1,CRK,PIK3R1
p38alphabetapathway	Regulation of p38-alpha and p38-beta	0.849532148639138	-0.163069494396537	27	24	0.0116845180136319	2054	2226	80824,5062,2534,83605,1843,5058,640,1432,1850,4067,6416,5608,5879,3932,7189,11221,8737,6714,5606,7525,2268,10454,4215,5600	DUSP16,PAK2,FYN,CCM2,DUSP1,PAK1,BLK,MAPK14,DUSP8,LYN,MAP2K4,MAP2K6,RAC1,LCK,TRAF6,DUSP10,RIPK1,SRC,MAP2K3,YES1,FGR,TAB1,MAP3K3,MAPK11
botulinumtoxinpathway	Effects of Botulinum toxin	0.850668282100001	-0.161733024166993	9	8	0.00389483933787731	2054	2226	6812,22999,25782,1134,10497,6844,6616,6857	STXBP1,RIMS1,RAB3GAP2,CHRNA1,UNC13B,VAMP2,SNAP25,SYT1
ecadherin_1_pathway	E-cadherin signaling events	0.851401112489554	-0.160871918929843	2	2	0.000973709834469328	2054	2226	1499,999	CTNNB1,CDH1
plk2_4pathway	PLK2 and PLK4 events	0.851401112489554	-0.160871918929843	2	2	0.000973709834469328	2054	2226	10733,10769	PLK4,PLK2
rhoa_reg_pathway	Regulation of RhoA activity	0.86054745518349	-0.150186516468253	46	41	0.0199610516066212	2054	2226	397,57522,10451,9639,394,9828,7410,23370,55160,50619,613,7409,9826,11214,29,9138,25791,10160,64283,2909,7984,64411,9181,116985,23365,7204,84033,10395,22899,396,1894,55200,387,1027,10276,115557,64333,23263,23779,4650,50650	ARHGDIB,SRGAP1,VAV3,ARHGEF10,ARHGAP5,ARHGEF17,VAV2,ARHGEF18,ARHGEF10L,DEF6,BCR,VAV1,ARHGEF11,AKAP13,ABR,ARHGEF1,NGEF,FARP1,ARHGEF28,ARHGAP35,ARHGEF5,ARAP3,ARHGEF2,ARAP1,ARHGEF12,TRIO,OBSCN,DLC1,ARHGEF15,ARHGDIA,ECT2,PLEKHG6,RHOA,CDKN1B,NET1,ARHGEF25,ARHGAP9,MCF2L,ARHGAP8,MYO9B,ARHGEF3
syndecan_3_pathway	Syndecan-3-mediated signaling events	0.86135913210071	-0.149243751067004	17	15	0.00730282375851996	2054	2226	3576,6714,4160,23385,5443,1956,1463,181,83464,5764,2017,2534,9672,51107,5663	CXCL8,SRC,MC4R,NCSTN,POMC,EGFR,NCAN,AGRP,APH1B,PTN,CTTN,FYN,SDC3,APH1A,PSEN1
smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling	0.87247574213554	-0.13642042800204	76	68	0.0331061343719572	2054	2226	4092,1019,1387,4208,1017,8819,79753,6667,4089,4087,1051,8850,10499,2309,3456,5054,3065,3725,1030,2290,25942,6497,2908,3693,8648,3665,1385,51588,3915,1278,6929,5933,467,6498,7027,51586,3066,145258,1487,2625,1026,4609,7709,5928,2099,10284,2033,23309,4149,60436,2353,4654,3312,4088,1482,1745,865,860,9611,3567,2308,7421,55802,3586,7050,3172,1386,207	SMAD7,CDK4,CREBBP,MEF2C,CDK2,SAP30,SNIP1,SP1,SMAD4,SMAD2,CEBPB,KAT2B,NCOA2,FOXO3,IFNB1,SERPINE1,HDAC1,JUN,CDKN2B,FOXG1,SIN3A,SKI,NR3C1,ITGB5,NCOA1,IRF7,CREB1,PIAS4,LAMC1,COL1A2,TCF3,RBL1,ATF3,SKIL,TFDP1,MED15,HDAC2,GSC,CTBP1,GATA3,CDKN1A,MYC,ZBTB17,RBBP4,ESR1,SAP18,EP300,SIN3B,MAX,TGIF2,FOS,MYOD1,HSPA8,SMAD3,NKX2-5,DLX1,CBFB,RUNX2,NCOR1,IL5,FOXO1,VDR,DCP1A,IL10,TGIF1,HNF4A,ATF2,AKT1
s1p_s1p5_pathway	S1P5 pathway	0.877875170108109	-0.130250870730385	8	7	0.00340798442064265	2054	2226	2770,2773,2768,2781,2771,53637,387	GNAI1,GNAI3,GNA12,GNAZ,GNAI2,S1PR5,RHOA
glypican_3pathway	Glypican 3 network	0.877875170108109	-0.130250870730385	8	7	0.00340798442064265	2054	2226	5045,5727,2252,6469,5599,652,5601	FURIN,PTCH1,FGF7,SHH,MAPK8,BMP4,MAPK9
ceramide_pathway	Ceramide signaling pathway	0.880954809413371	-0.126748949011549	44	39	0.0189873417721519	2054	2226	5154,7132,9530,5594,8575,6609,8567,4609,5590,4792,55512,8738,5610,5595,427,1950,8772,4790,9448,5894,5580,841,596,330,7124,5605,207,8717,54205,5970,6416,56848,4214,581,5604,1509,8737,5074,5599	PDGFA,TNFRSF1A,BAG4,MAPK1,PRKRA,SMPD1,MADD,MYC,PRKCZ,NFKBIA,SMPD3,CRADD,EIF2AK2,MAPK3,ASAH1,EGF,FADD,NFKB1,MAP4K4,RAF1,PRKCD,CASP8,BCL2,BIRC3,TNF,MAP2K2,AKT1,TRADD,CYCS,RELA,MAP2K4,SPHK2,MAP3K1,BAX,MAP2K1,CTSD,RIPK1,PAWR,MAPK8
circadianpathway	Circadian rhythm pathway	0.912261466846744	-0.0918286338933939	14	12	0.00584225900681597	2054	2226	1454,1111,545,4862,8553,5187,11091,9575,406,50514,9572,8914	CSNK1E,CHEK1,ATR,NPAS2,BHLHE40,PER1,WDR5,CLOCK,BMAL1,DELEC1,NR1D1,TIMELESS
epha_fwdpathway	EPHA forward signaling	0.91433932820345	-0.0895535201864348	31	27	0.0131450827653359	2054	2226	1943,4067,5335,640,1946,22899,1944,1942,2268,387,1969,3932,6714,7525,7410,2044,2046,2534,1020,10451,867,2043,25791,2045,285220,1398,2042	EFNA2,LYN,PLCG1,BLK,EFNA5,ARHGEF15,EFNA3,EFNA1,FGR,RHOA,EPHA2,LCK,SRC,YES1,VAV2,EPHA5,EPHA8,FYN,CDK5,VAV3,CBL,EPHA4,NGEF,EPHA7,EPHA6,CRK,EPHA3
ephrinb_ephbpathway	EphrinB-EPHB pathway	0.927589728126041	-0.0751657472648752	6	5	0.00243427458617332	2054	2226	2048,2049,2047,2050,1948	EPHB2,EPHB3,EPHB1,EPHB4,EFNB2
hes_heypathway	Notch-mediated HES/HEY network	0.92778082785574	-0.074959750969678	48	42	0.0204479065238559	2054	2226	9611,4602,632,3516,6774,405,429,142,6929,3280,9794,7291,256297,7528,4654,8648,817,84441,23013,50674,9612,1027,860,23493,2690,5925,3091,2626,23462,3065,2033,3717,1869,55502,23028,1387,1827,7088,3791,920,2548,1487	NCOR1,MYB,BGLAP,RBPJ,STAT3,ARNT,ASCL1,PARP1,TCF3,HES1,MAML1,TWIST1,PTF1A,YY1,MYOD1,NCOA1,CAMK2D,MAML2,SPEN,NEUROG3,NCOR2,CDKN1B,RUNX2,HEY2,GHR,RB1,HIF1A,GATA4,HEY1,HDAC1,EP300,JAK2,E2F1,HES6,KDM1A,CREBBP,RCAN1,TLE1,KDR,CD4,GAA,CTBP1
p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta	0.951724036292651	-0.0494801640573288	35	30	0.0146056475170399	2054	2226	7157,8986,4208,4205,26959,1977,1051,2099,5321,3880,466,3725,10891,5600,3315,1978,1385,22926,9252,6548,5868,4286,7867,7391,3856,1386,9261,1432,5743,2005	TP53,RPS6KA4,MEF2C,MEF2A,HBP1,EIF4E,CEBPB,ESR1,PLA2G4A,KRT19,ATF1,JUN,PPARGC1A,MAPK11,HSPB1,EIF4EBP1,CREB1,ATF6,RPS6KA5,SLC9A1,RAB5A,MITF,MAPKAPK3,USF1,KRT8,ATF2,MAPKAPK2,MAPK14,PTGS2,ELK4
p75ntrpathway	p75(NTR)-mediated signaling	0.983503117082708	-0.0166344717806104	61	52	0.0253164556962025	2054	2226	4314,5584,4692,8878,4909,5602,4974,6868,6272,396,56616,4804,56160,5599,10018,4099,57142,5340,387,7189,5290,4615,839,83464,3551,1869,11108,6610,7531,317,5045,4803,5879,4316,51107,54205,5663,207,23385,5601,1147,4908,5590,351,842,65078,7157,627,8767,5295,6464,836	MMP3,PRKCI,NDN,SQSTM1,NTF4,MAPK10,OMG,ADAM17,SORT1,ARHGDIA,DIABLO,NGFR,NSMCE3,MAPK8,BCL2L11,MAG,RTN4,PLG,RHOA,TRAF6,PIK3CA,MYD88,CASP6,APH1B,IKBKB,E2F1,PRDM4,SMPD2,YWHAE,APAF1,FURIN,NGF,RAC1,MMP7,APH1A,CYCS,PSEN1,AKT1,NCSTN,MAPK9,CHUK,NTF3,PRKCZ,APP,CASP9,RTN4R,TP53,BDNF,RIPK2,PIK3R1,SHC1,CASP3
cdc42_reg_pathway	Regulation of CDC42 activity	0.993551940178602	-0.00646893835822418	30	24	0.0116845180136319	2054	2226	50618,10928,57572,396,5335,998,55114,8874,221178,392,115557,23263,23348,23268,10451,28964,7410,6453,4830,55619,25791,324,29127,8412	ITSN2,RALBP1,DOCK6,ARHGDIA,PLCG1,CDC42,ARHGAP17,ARHGEF7,SPATA13,ARHGAP1,ARHGEF25,MCF2L,DOCK9,DNMBP,VAV3,GIT1,VAV2,ITSN1,NME1,DOCK10,NGEF,APC,RACGAP1,BCAR3
glypican_2pathway	Glypican 2 network	0.994061600892929	-0.0059561015164884	2	1	0.000486854917234664	2054	2226	4192	MDK
glypicanpathway	Glypican pathway	0.999546075605504	-0.000454027449361183	3	1	0.000486854917234664	2054	2226	2817	GPC1